gebhart/patrepeval huggingface dataset:
Ultraviolet, Visible, Circular Dichroism, and Electron Paramagnetic Resonance Spectra of the Copper(II) Complexes of Thyroxine and Thyroxine Analogs<sup>*</sup> (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltraviolet, Visible, Circular Dichroism, and Electron Paramagnetic Resonance Spectra of the Copper(II) Complexes of Thyroxine and Thyroxine Analogs*Robert Zand and Graham PalmerCite this: Biochemistry 1967, 6, 4, 999–1007Publication Date (Print):April 1, 1967Publication History Published online1 May 2002Published inissue 1 April 1967https://pubs.acs.org/doi/10.1021/bi00856a007https://doi.org/10.1021/bi00856a007research-articleACS PublicationsRequest reuse permissionsArticle Views138Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mad as Hell (1998)

Anyone who really wants to know what's on the minds of bankers these days should get on an airplane and go find out. That's what I and the other officers have been doing for the past six months, and we've learned a great deal. We've been traveling from city to town around the country to meet informally with groups of bankers and to ask what matters most to them. We call these gatherings ABA Town Meetings, and they help us learn what bankers in the heart and soul of America are thinking about their industry, the Congress, their institutions' business prospects, and the shape of tomorrow. I've found the half-dozen or so meetings I've attended terrifically refreshing. Believe me, these visits are a welcome change from visiting the corridors of power on Capitol Hill, where lobbying banking issues and banging one's head against a wall are strangely similar experiences. And, yes, some of the bankers we encounter on these trips are mad as hell. They're mad at Congress, they're mad at the media and the way it portrays our industry, or they're just plain frustrated that on issues such as credit unions and financial modernization, many people just don't seem to get it. Personally, I think the anger is a good thing. It means that bankers have been unhappy with what's been coming out of Washington lately for their industry, and they want to do something about it. I was in Tulsa and Oklahoma City for Town Meetings in early April. The also held Town Meetings this spring in Iowa and Missouri, and with the Texas Bankers Association in Nevada. Earlier I was in Hartford and Boston for Town Meetings. The Oklahoma meetings took place just after the House of Representatives voted to approve the credit union bill (H.R. 1151), and that event was very much on bankers' minds. Bill Phillips of ABA's government relations staff was there. He observed that the mood of bankers over the credit union bill combined real anger with painful disappointment. Both emotions were directed at their Congressional representatives who had indicated understanding and support and then let them down. The credit union issue, along with the unitary thrift holding company loophole, dominated the discussions. No one was more angry, disappointed and frustrated than me over the lopsided House vote, and the entire way in which Congress has handled the credit union issue. (Do you suppose that the fact that it's an election year has anything to do with Congress giving in so easily to the demands of credit unions? …
Snow White Clouds and the Seven Dwarfs (2011)

With increasing availability of Cloud computing services, this paper addresses the challenge consumers of Infrastructure-as-a-Service (IaaS) have in determining which IaaS provider and resources are best suited to run an application that may have specific Quality of Service (QoS) requirements. Utilising application modelling to predict performance is an attractive concept, but is very difficult with the limited information IaaS providers typically provide about the computing resources. This paper reports on an initial investigation into using Dwarf benchmarks to measure the performance of virtualised hardware, conducting experiments on BonFIRE and Amazon EC2. The results we obtain demonstrate that labels such as 'small', 'medium', 'large' or a number of ECUs are not sufficiently informative to predict application performance, as one might expect. Furthermore, knowing the CPU speed, cache size or RAM size is not necessarily sufficient either as other complex factors can lead to significant performance differences. We show that different hardware is better suited for different types of computations and, thus, the relative performance of applications varies across hardware. This is reflected well by Dwarf benchmarks and we show how different applications correlate more strongly with different Dwarfs, leading to the possibility of using Dwarf benchmark scores as parameters in application models.
Analysis and optimization of message acceptance filter configurations for controller area network (CAN) (2017)

Many of the processors used in automotive Electronic Control Units (ECUs) are resource constrained due to the cost pressures of volume production; they have relatively low clock speeds and limited memory. Controller Area Network (CAN) is used to connect the various ECUs; however, the broadcast nature of CAN means that every message transmitted on the network can potentially cause additional processing load on the receiving nodes, whether the message is relevant to that ECU or not. Hardware filters can reduce or even eliminate this unnecessary load by filtering out messages that are not needed by the ECU. Filtering is done on the message IDs which are primarily used to identify the contents of the message and its priority. In this paper, we consider the problem of selecting filter configurations to minimize the load due to undesired messages. We show that the general problem is NP-complete. We therefore propose and evaluate an approach based on Simulated Annealing. We show that this approach finds near-optimal filter configurations for the interesting case where there are more desired messages than available filters.
Combination of CTLA-4 and PD-1 blockers for treatment of cancer (2019)

Targeting checkpoints of immune cell activation has been demonstrated to be the most effective approach for activation of anti-tumor immune responses. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1), both inhibitory checkpoints commonly seen on activated T-cells have been found to be the most reliable targets for the treatment of cancer. Six drugs targeting PD-1 or its ligand PD-L1 and one drug targeting CTLA-4 have been approved for treatment of different types of cancers and several others are in advanced stages of development. The drugs when administered as monotherapy had dramatic increase in durable response rates and had manageable safety profile, but more than 50% of patients failed to respond to treatment. Combination of CTLA-4 and PD-1 blockers was then evaluated to increase the response rates in patients, and ipilimumab (anti-CTLA-4) plus nivolumab (anti-PD-1) combination was shown to significantly enhance efficacy in metastatic melanoma patients. Subsequently, ipilimumab plus nivolumab was approved for treatment of metastatic melanoma, advanced renal cell carcinoma and metastatic colorectal cancer with MMR/MSI-H aberrations. The success of combination encouraged multiple clinical studies in other cancer types. Efficacy of the combination has been shown in a number of published studies and is under evaluation in multiple ongoing studies. This review aims to support future research in combination immunotherapy by discussing the basic details of CTLA-4 and PD-1 pathways and the results from clinical studies that evaluated combination of CTLA-4 and PD-1/PD-L1 blockers.
Background Subtraction Using Markov Thresholds (2005)

Many video surveillance and identification applications need to find moving objects in the field of view of a stationary camera. A popular method for obtaining these silhouettes is through the process of background subtraction. We present a novel method for comparing image frames to the model of the stationary background that exploits the spatial and temporal dependencies that objects in motion impose on their images. We achieve this through the development and use of Markov random fields of binary segmentation variates. We show that the MRF approach produces more accurate and visually appealing silhouettes that are less prone to noise and background camouflaging effects than traditional per-pixel based methods. Results include visual examination of silhouettes, comparisons against hand-segmented data, and an analysis of the effects of various silhouette extraction techniques on gait recognition performance.
Die Wirkung von Strahlen auf Acetabularia (1958)

Es wird der Einfluß von Röntgenstrahlen und ultravioletten Strahlen verschiedener Wellenlängen auf kernhaltige Zellteile von Acetabularia mediterranea untersucht. Die Röntgenbestrahlung führt zu einer Verminderung des Regenerationsvermögens der Zellteile, zu einer Verringerung der Cystenbildung der Regenerate und zu einer Herabsetzung der Lebensfähigkeit der Cysten. Erst nach einer Dosis von 400 kr ist das Regenerationsvermögen fast völlig zerstört. Die Fähigkeit zur Bildung fortpflanzungsfähiger Gameten geht bereits nach 40 kr verloren. Die Wirkung von UV-Bestrahlungen ist demgegenüber sehr gering. Es wird geschlossen, daß die beobachteten Leistungen der kernhaltigen Zellteile wesentlich durch den Zellkern bestimmt sind, der im Rhizoid gegen die UV-Strahlung weitgehend abgeschirmt ist. Erfolgt eine vollständige Regeneration bis zur Hutbildung, so scheinen Größe und Gestalt der ausgewachsenen Regenerate nicht wesentlich von der Röntgenbestrahlung beeinflußt zu sein. In den meisten Fällen bilden Hutregenerate auch Cysten.
Distinct Requirements for IFNs and STAT1 in NK Cell Function (2000)

NK cell functions were examined in mice with a targeted mutation of the STAT1 gene, an essential mediator of IFN signaling. Mice deficient in STAT1 displayed impaired basal NK cytolytic activity in vitro and were unable to reject transplanted tumors in vivo, despite the presence of normal numbers of NK cells. IL-12 enhanced NK-mediated cytolysis, but poly(I:C) did not, and a similar phenotype occurred in mice lacking IFNalpha receptors. Molecules involved in activation and lytic function of NK cells (granzyme A, granzyme B, perforin, DAP10, and DAP12) were expressed at comparable levels in both wild-type and STAT1(-/-) mice, and serine esterase activity necessary for CTL function was normal, showing that the lytic machinery was intact. NK cells with normal cytolytic activity could be derived from STAT1(-/-) bone marrow progenitors in response to IL-15 in vitro, and enhanced NK lytic activity and normal levels of IFN-gamma were produced in response to IL-12 treatment in vivo. Despite these normal responses to cytokines, STAT1(-/-) mice could not reject the NK-sensitive tumor RMA-S, even following IL-12 treatment in vivo. Whereas in vitro NK cytolysis was also reduced in mice lacking both type I and type II IFN receptors, these mice resisted tumor challenge. These results demonstrate that both IFN-alpha and IFN-gamma are required to maintain NK cell function and define a STAT1-dependent but partially IFN-independent pathway required for NK-mediated antitumor activity.
Improved Reagents for Newborn Screening of Mucopolysaccharidosis Types I, II, and VI by Tandem Mass Spectrometry (2014)

Tandem mass spectrometry for the multiplex and quantitative analysis of enzyme activities in dried blood spots on newborn screening cards has emerged as a powerful technique for early assessment of lysosomal storage diseases. Here we report the design and process-scale synthesis of substrates for the enzymes α-l-iduronidase, iduronate-2-sulfatase, and N-acetylgalactosamine-4-sulfatase that are used for newborn screening of mucopolysaccharidosis types I, II, and VI. The products contain a bisamide unit that is hypothesized to readily protonate in the gas phase, which improves detection sensitivity by tandem mass spectrometry. The products contain a benzoyl group, which provides a useful site for inexpensive deuteration, thus facilitating the preparation of internal standards for the accurate quantification of enzymatic products. Finally, the reagents are designed with ease of synthesis in mind, thus permitting scale-up preparation to support worldwide newborn screening of lysosomal storage diseases. The new reagents provide the most sensitive assay for the three lysosomal enzymes reported to date as shown by their performance in reactions using dried blood spots as the enzyme source. Also, the ratio of assay signal to that measured in the absence of blood (background) is superior to all previously reported mucopolysaccharidosis types I, II, and VI assays.
Regioselective Esterification and Etherification of Cellulose: A Review (2011)

Deep understanding of the structure-property relationships of polysaccharide derivatives depends on the ability to control the position of the substituents around the monosaccharide ring and along the chain. Equally important is the ability to analyze position of substitution. Historically, both synthetic control and analysis of regiochemistry have been very difficult for cellulose derivatives, as for most other polysaccharide derivatives. With the advent of cellulose solvents that are suitable for chemical transformations, it has become possible to carry out cellulose derivatization under conditions sufficiently mild to permit increasingly complete regiochemical control, particularly with regard to the position of the substituents around the anhydroglucose ring. In addition, new techniques for forming cellulose and its derivatives from monomers, either by enzyme-catalyzed processes or chemical polymerization, permit us to address new frontiers in regiochemical control. We review these exciting developments in regiocontrolled synthesis of cellulose derivatives and their implications for in-depth structure-property studies.
Nitrogen and phosphorus co-doped cubic ordered mesoporous carbon as a supercapacitor electrode material with extraordinary cyclic stability (2015)

Cubic ordered mesoporous carbon co-doped with N and P shows a high specific capacitance of 210 F g<sup>−1</sup> at 1.0 A g<sup>−1</sup> and excellent retention of specific capacitance with more than 90% of initial capacitance at a high current density of 10 A g<sup>−1</sup> and also for 3000 charge–discharge cycles.
The Role of the Effective Cloud Albedo for Climate Monitoring and Analysis (2011)

Cloud properties and the Earth’s radiation budget are defined as essential climate variables by the Global Climate Observing System (GCOS). The cloud albedo is a measure for the portion of solar radiation reflected back to space by clouds. This information is essential for the analysis and interpretation of the Earth’s radiation budget and the solar surface irradiance. We present and discuss a method for the production of the effective cloud albedo and the solar surface irradiance based on the visible channel (0.45–1 μm) on-board of the Meteosat satellites. This method includes a newly developed self-calibration approach and has been used to generate a 23-year long (1983–2005) continuous and validated climate data record of the effective cloud albedo and the solar surface irradiance. Using this climate data record we demonstrate the ability of the method to generate the two essential climate variables in high accuracy and homogeneity. Further on, we discuss the role of the cloud albedo within climate monitoring and analysis. We found trends with opposite sign in the observed effective cloud albedo resulting in positive trends in the solar surface irradiance over ocean and partly negative trends over land. Ground measurements are scarce over the ocean and thus satellite-derived effective cloud albedo and solar surface irradiance constitutes a unique observational data source. Within this scope it has to be considered that the ocean is the main energy reservoir of the Earth, which emphasises the role of satellite-observed effective cloud albedo and derived solar surface irradiance as essential climate variables for climate monitoring and analysis.
OpenCyto: An Open Source Infrastructure for Scalable, Robust, Reproducible, and Automated, End-to-End Flow Cytometry Data Analysis (2014)

Flow cytometry is used increasingly in clinical research for cancer, immunology and vaccines. Technological advances in cytometry instrumentation are increasing the size and dimensionality of data sets, posing a challenge for traditional data management and analysis. Automated analysis methods, despite a general consensus of their importance to the future of the field, have been slow to gain widespread adoption. Here we present OpenCyto, a new BioConductor infrastructure and data analysis framework designed to lower the barrier of entry to automated flow data analysis algorithms by addressing key areas that we believe have held back wider adoption of automated approaches. OpenCyto supports end-to-end data analysis that is robust and reproducible while generating results that are easy to interpret. We have improved the existing, widely used core BioConductor flow cytometry infrastructure by allowing analysis to scale in a memory efficient manner to the large flow data sets that arise in clinical trials, and integrating domain-specific knowledge as part of the pipeline through the hierarchical relationships among cell populations. Pipelines are defined through a text-based csv file, limiting the need to write data-specific code, and are data agnostic to simplify repetitive analysis for core facilities. We demonstrate how to analyze two large cytometry data sets: an intracellular cytokine staining (ICS) data set from a published HIV vaccine trial focused on detecting rare, antigen-specific T-cell populations, where we identify a new subset of CD8 T-cells with a vaccine-regimen specific response that could not be identified through manual analysis, and a CyTOF T-cell phenotyping data set where a large staining panel and many cell populations are a challenge for traditional analysis. The substantial improvements to the core BioConductor flow cytometry packages give OpenCyto the potential for wide adoption. It can rapidly leverage new developments in computational cytometry and facilitate reproducible analysis in a unified environment.
A heterogeneous multiprocessor design and the distributed scheduling of its task group workload (1982)

A multiprocessor architecture is proposed which is based on the Multics concept of having all on-line information processor-addressible. All memory management is done by an intelligent paged virtual memory system, and each processor deals only with those segments relevant to its single executing program. The processors are chosen to have different implementations of a single system-wide instruction set and the problem is to effectively schedule different categories of programs, called task groups, on the dissimilar processors. Average weighted instruction times for each task group on every processor are defined as task/processor suitability measures, and typical values are given for different groups of programs running on IBM 370 models. Through the use of linear programming techniques, an optimal schedule for any such multiprocessor is then defined for the static case where task group loads and task/processor suitability values are known in advance. A priority-based task management scheduling algorithm is then defined which uses the optimal schedule of the formal model as a parameter, and its performance is simulated.
Drugs in the workplace. (1984)

Many corporations are making concerted efforts to reduce the growing costs of on-the-job intoxication by the use of preemployment urine screening and breath alcohol testing, in addition to the more traditional histories and physical examinations. The worker who is accident prone, frequently ill, demonstrates poor work performance, or who seems to be under the influence of a mind-altering drug is examined for possible drug toxicity. Disciplinary action must be equitable and with the concurrence of the union. The advantages and problems associated with the chemical testing procedure and the safeguards to the individual and the corporation are discussed.
Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation (2011)

Follicular helper T (T(FH)) cells are critical for germinal center (GC) formation. The processes that drive their generation and effector potential remain unclear. In this study, we define requirements for MHC class II APCs in murine T(FH) cell formation by either transiently ablating or restricting Ag presentation to dendritic cells (DCs). We find that cognate interactions with DCs are necessary and sufficient to prime CD4(+) T cells toward a CXCR5(+)ICOS(+)Bcl6(+) T(FH) cell intermediate. However, in the absence of additional APCs, these T(FH) cells fail to produce IL-21. Furthermore, in vitro priming of naive T cells by B cells engenders optimal production of IL-21, which induces a GC B cell transcriptional profile. These results support a multistep model for effector T(FH) cell priming and GC initiation, in which DCs are necessary and sufficient to induce a T(FH) cell intermediate that requires additional interactions with distinct APCs for full effector function.
Cisplatin Ototoxicity and Protection: Clinical and Experimental Studies (2009)

Cisplatin is a chemotherapeutic agent that is widely used to treat a variety of malignant tumors. Serious dose-limiting side effects like ototoxicity, nephrotoxicity and neurotoxicity occur with the use of this agent. This review summarizes recent important clinical and experimental investigations of cisplatin ototoxicity. It also discusses the utility of protective agents employed in patients and in experimental animals. The future strategies for limiting cisplatin ototoxicity will need to avoid interference with the therapeutic effect of cisplatin in order to enhance the quality of life of patients receiving this important anti-tumor agent.
Supervised dimensionality reduction via distance correlation maximization (2018)

In our work, we propose a novel formulation for supervised dimensionality reduction based on a nonlinear dependency criterion called Statistical Distance Correlation, (Székely et al., 2007). We propose an objective which is free of distributional assumptions on regression variables and regression model assumptions. Our proposed formulation is based on learning a low-dimensional feature representation $\mathbf{z}$, which maximizes the squared sum of Distance Correlations between low-dimensional features $\mathbf{z}$ and response $y$, and also between features $\mathbf{z}$ and covariates $\mathbf{x}$. We propose a novel algorithm to optimize our proposed objective using the Generalized Minimization Maximization method of (Parizi et al., 2015). We show superior empirical results on multiple datasets proving the effectiveness of our proposed approach over several relevant state-of-the-art supervised dimensionality reduction methods.
Least Squares Conformal Maps (2002)

Colloque sans acte à diffusion restreinte. internationale.