gebhart/patrepeval huggingface dataset:
Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence (2006)

Specific mammalian genes functionally and dynamically associate together within the nucleus. Yet, how an array of many genes along the chromosome sequence can be spatially organized and folded together is unknown. We investigated the 3D structure of a well-annotated, highly conserved 4.3-Mb region on mouse chromosome 14 that contains four clusters of genes separated by gene "deserts." In nuclei, this region forms multiple, nonrandom "higher order" structures. These structures are based on the gene distribution pattern in primary sequence and are marked by preferential associations among multiple gene clusters. Associating gene clusters represent expressed chromatin, but their aggregation is not simply dependent on ongoing transcription. In chromosomes with aggregated gene clusters, gene deserts preferentially align with the nuclear periphery, providing evidence for chromosomal region architecture by specific associations with functional nuclear domains. Together, these data suggest dynamic, probabilistic 3D folding states for a contiguous megabase-scale chromosomal region, supporting the diverse activities of multiple genes and their conserved primary sequence organization.
An 11-Mb/s 2.1-mW Synchronous Superregenerative Receiver at 2.4 GHz (2007)

This paper presents a low-voltage low-power high-speed superregenerative receiver operating in the 2.4-GHz industrial-scientific-medical band. The receiver uses an architecture in which, thanks to the presence of a phase-locked loop, the quench oscillator is operated synchronously with the received data at a quench frequency equal to the data rate. This mode of operation has several benefits. Firstly, the traditional problem of poor selectivity in this type of receiver is to a large extent overcome. Secondly, considerably higher data rates can be achieved than with classical receivers. Thirdly, the bit envelope can be matched to the superregenerative oscillator, which improves sensitivity. The receiver includes an RF front end optimized to support high quench frequencies at low supply voltages, responding to todays increasing demand for high speed and low power consumption. The prototype implemented is very simple and achieves a data rate of 11 Mb/s with a current consumption of 1.75 mA at a supply voltage of 1.2 V - an excellent tradeoff between cost, performance, and power consumption.
In Situ Synthesis of Ferrites in Cellulosics (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleIn Situ Synthesis of Ferrites in CellulosicsLouise Raymond, J.-F. Revol, D. H. Ryan, and R. H. MarchessaultCite this: Chem. Mater. 1994, 6, 2, 249–255Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/cm00038a025https://doi.org/10.1021/cm00038a025research-articleACS PublicationsRequest reuse permissionsArticle Views334Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Photochemical dimerization of a benzoselenete derivative (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical dimerization of a benzoselenete derivativeShoko Yamazaki, Keijiro Kohgami, Megumi Okazaki, Shinichi Yamabe, and Toshio AraiCite this: J. Org. Chem. 1989, 54, 1, 240–243Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/jo00262a050https://doi.org/10.1021/jo00262a050research-articleACS PublicationsRequest reuse permissionsArticle Views152Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Immunosuppressive activity of cyclolinopeptide A. (1992)

Cyclolinopeptide A (CLA), a cyclic natural nonapeptide isolated in 1959 from linseed oil, was found to possess the immunosuppressive activity of the range comparable to that of cyclosporin A (CS-A). The influence of CLA on the primary and secondary humoral response was determined by the plaque-forming cells test, performed in vitro as well as in vivo. The effect of CLA on the cellular immune response in mice was examined by using (i) the delayed-type hypersensitivity test, (ii) the skin-allograft rejection and (iii) the graft-vs.-host reaction. It was also found that CLA influences human lymphocyte proliferation in vitro and tempers the post-adjuvant polyarthritis in rats and hemolytic anemia of New Zealand Black mice. In all tests performed, the activities of CLA and CS-A were practically the same. Using the plaque-forming cells test and the autologous rosette-forming cells test, we have shown that CLA, like CS-A, inhibits the action of Interleukin-1-alpha and Interleukin-2. Our experiments performed with mice and rats show that intraperitoneal, per os, as well as intravenous application of relatively large doses of CLA does not produce toxic effects. The strong immunosuppressive activity of CLA makes the peptide very interesting from the point of view of its possible utilization in medicine.
Chimeric antigen receptor signaling: Functional consequences and design implications (2020)

Chimeric antigen receptor (CAR) T cell therapy has transformed the care of refractory B cell malignancies and holds tremendous promise for many aggressive tumors. Despite overwhelming scientific, clinical, and public interest in this rapidly expanding field, fundamental inquiries into CAR T cell mechanistic functioning are still in their infancy. Because CAR T cells are manufactured from donor T lymphocytes, and because CARs incorporate well-characterized T cell signaling components, it has largely been assumed that CARs signal analogously to canonical T cell receptors (TCRs). However, recent studies demonstrate that many aspects of CAR signaling are unique, distinct from endogenous TCR signaling, and potentially even distinct among various CAR constructs. Thus, rigorous and comprehensive proteomic investigations are required for rational engineering of improved CARs. Here, we review what is known about proximal CAR signaling in T cells, compare it to conventional TCR signaling, and outline unmet challenges to improving CAR T cell therapy.
Effect of the Tibial Cut on Subsidence Following Total Knee Arthroplasty (1991)

In 33 total knee arthroplasties (TKAs) using instrumentation designed to cut the tibia with 0 degree posterior slope, ten tibial components demonstrated at least 2 mm of tibial component subsidence. These subsided components were implanted onto tibiae with an average of 8 degrees +/- 2 degrees difference between the preoperative, anatomic posterior slope and their postoperative posterior slope. The remaining 23 components, without subsidence, were implanted onto tibiae cut within 2 degrees +/- 2 degrees of their anatomic slope. To help understand these clinical observations, a laboratory study was performed to compare the load carrying capacity and the stiffness of tibial subchondral bone following two types of tibial cuts: one made perpendicular to the long axis of the tibia and the other made parallel to the articular surface of the tibia. Mock tibial baseplates mounted on paired cadaver tibiae were loaded in compression and force displacement curves were recorded. Tibiae cut parallel to the surface exhibited 40% greater load carrying capacity and 70% greater stiffness than the paired tibiae cut perpendicular to the long axis. The biomechanical data of this study indicated that cutting the tibia perpendicular to the long axis results in weaker bone that may be inadequate to support a tibial component. This may explain the higher incidence of clinical subsidence if the tibial cut is not made approximately parallel to the anatomic slope.
Poor Glycemic Control Induces Hypertension in Diabetes Mellitus (1996)

We conducted this study to test the hypothesis that hypertension is a primary consequence of poor glycemic control per se very early in insulin-dependent diabetes mellitus. Sprague-Dawley rats (n=15) were instrumented with artery and vein catheters, placed in metabolic cages, and sodium intake was clamped throughout the study. Mean arterial pressure was measured 24 h/d. After a precontrol period, streptozotocin (70 mg/kg IV) was administered, and 15 hours later a continuous intravenous infusion was begun at 4 U/rat per day. The insulin infusion was titrated on an individual rat basis to maintain good glycemic control, and after this 7-day control period, blood glucose, urinary sodium excretion, and mean arterial pressure were not different from precontrol values, averaging 8.8 +/- 0.6 mmol/L, 2.8 +/- 0.2 mmol/d, and 103 +/- 2 mm/Hg, respectively, for control days 5 through 7. Subsequently, a 4-day period of poor glycemic control was initiated by reducing the insulin infusion rate. Blood glucose, urinary sodium excretion, and mean arterial pressure began to increase on day 1; for diabetes days 3 and 4, they averaged 23.4 +/- 1.0 mmol/L, 3.6 +/- 0.1 mmol/d, and 110 +/- 2 mm Hg, respectively. All were significantly elevated. When insulin treatment was restored, all variables returned to control levels during the next 4 days. A second 4-day diabetic period yielded similar results. These results indicate that elevated blood pressure is a primary consequence of poor glycemic control in insulin-dependent diabetes, occurring before renal injury has had time to develop, and therefore, may be a factor contributing to the initiation of end-organ injury.
Microfluidics for biomedical applications (2007)

In the past decade, microfabrication of miniature fluidic devices has attracted considerable interest and made substantial impacts. One of the most promising applications is for biosensing. In this talk, several bio-sensing chips using the enabling microfluidic technology will be presented. Microfluidic systems for molecular diagnosis and immunoassay have been developed for fast diagnosis.
Age-related macular degeneration and mortality from cardiovascular disease or stroke (2008)

AMD predicted stroke and cardiovascular events over the long term in persons aged 49-75 years. This may have potential implications for new intravitreal anti-VEGF AMD therapies.
Solubility Measurements of Benzene and the Alkylbenzenes in Water by Making Use of Solute Vapor (1982)

Abstract Aqueous solubilities of benzene and of alkylbenzenes, toluene, ethylbenzene, propyl- and isopropylbenzene, (o-, m-, and p-) xylene, and (1,2,3-, 1,2,4-, and 1,3,5-) trimethylbenzene, have been measured. An apparatus is described which provides a convenient means of obtaining aqueous solutions saturated with solute vapor. The method involves introducing solute vapor, which is in equilibrium with a liquid solute, into water and circulating it in a closed system. This method has three principal advantages: (1) The solubility equilibrium can be attained within 3 min, (2) it can be determined whether the solubility obeys Henry’s law, and (3) based on Henry’s law, solutions of any desired concentrations of solute at a given temperature of water can be easily prepared.
A Conditional Lethal Mutant of <i>Escherichia coli</i> K12 Defective in the 5′ → 3′ Exonuclease Associated with DNA Polymerase I (1974)

A mutant strain of E. coli, initially identified by an abnormally high frequency of recombination, has been found to be defective in the 5' --> 3' exonuclease associated with DNA polymerase I, but not in the polymerase activity. This defect is tolerated at 30 degrees , but is lethal at 43 degrees . Like other polymerase I mutants, the strain is unusually sensitive to methyl methanesulfonate and to ultraviolet irradiation; it is also unable to support the growth of phage lambda defective in general recombination, and shows a reduced rate of joining of 10S "Okazaki fragments." These results demonstrate that a functional DNA polymerase I is essential for normal growth and viability in E. coli K12.
Effects of war on the health care of Bosnian children (1996)

<h3>To the Editor.</h3> —During the nearly 4 years that Sarajevo, the capital city of Bosnia-Herzegovina, was under siege, 1602 children were killed and 14952 were injured,<sup>1</sup>and 37% of the population became refugees.<sup>2</sup>The city was isolated from the world community and experienced extended periods without food, running water, electricity, or natural gas. The Sarajevo Pedijatrijska Klinika, the main children's hospital for the city and a tertiary referral center for Bosnia, was directly shelled and completely destroyed.<sup>3</sup>This disruption continues to affect the health care of Bosnian children even after the Dayton peace accord brought an end to fighting in the area.<sup>2</sup> We interviewed the families of all 60 children (mean age 4.1, median 2.9, 1 day to 14.5 years; 35 boys, 25 girls) admitted during February 1996 to the relocated Klinika. Information obtained included age, sex, anthropometric measurements, diagnoses, injuries sustained by the children and
Seeded Growth of Titania Colloids with Refractive Index Tunability and Fluorophore-Free Luminescence (2011)

Titania is an important material in modern materials science, chemistry, and physics because of its special catalytic, electric, and optical properties. Here, we describe a novel method to synthesize colloidal particles with a crystalline titania, anatase core and an amorphous titania-shell structure. We demonstrate seeded growth of titania onto titania particles with accurate particle size tunability. The monodispersity is improved to such an extent so that colloidal crystallization of the grown microspheres becomes feasible. Furthermore, seeded growth provides separate manipulation of the core and shell. We tuned the refractive index of the amorphous shell between 1.55 and 2.3. In addition, the particles show luminescence when trace amounts of aminopropyl-triethoxysilane are incorporated into the titania matrix and are calcined at 450 °C. Our novel colloids may be useful for optical materials and technologies such as photonic crystals and optical trapping.
Parameter Optimization and Application of SVM Based on Gravitational Search Algorithm (2013)

In order to improve the fitting accuracy and generalization ability of the support vector machine(SVM) model,an algorithm for the SVM parameter optimization is proposed based on the gravitational search and minimizing the square sum of mean errors of the output.The simulated experiments show that the SVM regression model based on the gravitational search has a high accuracy and strong generalization ability.The proposed algorithm is applied to modeling in a glutamic acid fermentation process and the simulation results indicate that the proposed algorithm can improve the forecast accuracy of the glutamate concentration.
Three-Dimensional Computed Tomographic Analysis of the Primary Nasal Deformity in 3-Month-Old Infants with Complete Unilateral Cleft Lip and Palate (1999)

The purpose of this study was to analyze the geometry of the primary cleft lip nasal deformity using three-dimensional computerized tomography in a group of 3-month-old infants with complete unilateral cleft lip and palate before surgical intervention. Coordinates and axes were reconfigured after the three-dimensional image was oriented into neutral position (Frankfurt horizontal, true anteroposterior, and vertical midline). Display and measurement of skin surface and osseous tissues were achieved by adjusting the computed tomographic thresholds. S-N, N-ANS, S-N-O, and S-N-ANS were measured from true lateral views. Biorbital (LO-LO), interorbital (MO-MO), intercanthal (en-en), and nasal (al-al) widths were measured from the anteroposterior view. The bony alveolar cleft width was measured from the inferior view. The study group was divided into two groups on the basis of skeletal alveolar cleft width: six patients with clefts narrower than 10 mm and six patients with clefts wider than 10 mm. Only the S-N-ANS angle differed between the two groups, i.e., it was greater in the group with the wider clefts (p < 0.05). Coordinates of six landmarks at the base of the nose [sellion (se), subnasale (sn), cleft-side and noncleft-side subalare (sbal-cl and sbal-ncl), and the most posterior point on the lateral piriform margins (PPA-CL and PPA-NCL)] were obtained for analysis of the nasal deformity. On average, the subnasale point was anterior to sellion and deviated to the noncleft side; the cleft-side sbal point was more medial, posterior, and inferior than the noncleft-side sbal point; and the PPA point on the cleft-side piriform margin was more lateral, posterior, and inferior than the PPA point on the noncleft side. These discrepancies were not universally observed. However, in all patients, four findings were observed without exception (p < 0.01): (1) subnasale (sn) was deviated to the noncleft side (mean distance from midline, 5.0 mm; range, 2 to 9.5 mm), (2) the cleft-side alar base (sbal-cl) was more posterior than the noncleft-side alar base (sbal-ncl) (mean difference, 3.6 mm; range, 1 to 5.5 mm), (3) the noncleft-side alar base (sbal-ncl) was further from the midline than the cleft-side alar base (sbal-cl) (mean difference in lateral distances of sbal-ncl and sbal-cl from the midline, 2.8 mm; range, 0.5 to 7 mm), and (4) the cleft-side piriform margin (PPA-CL) was more posterior than the noncleft side piriform margin (PPA-NCL) (mean difference, 2.1 mm; range, 0.5 to 4 mm). In conclusion, the nasal deformity in unilateral cleft lip and palate that has not been operated on is characterized by these four features and increased S-N-ANS angle with increased alveolar cleft width.
Separation of Standard Opiates and Their Analysis in Pharmaceutical and Illicit Preparations by Paired-Ion Reverse-Phase High-Pressure Liquid Chromatography (1979)

The separation of standard opiates in a mixture and their analysis in clandestine and pharmaceutical preparations were accomplished by PIC on a micro-Bondapak C18 column. The identification of the opiates was based on two parameters: retention times and the ratios of absorbance peaks recorded at 254 and 280 nm. No prior clean-up procedure of samples was required for analysis by this method. Baseline separation of drug components in clandestine and in pharmaceutical preparations made this method suitable for their quantitation.
White phosphorescent organic light-emitting devices with dual triple-doped emissive layers (2009)

We demonstrate high efficiency white organic light-emitting devices with two adjacent emissive layers each doped with three phosphorescent emitters (blue, green, and red). Efficient charge and exciton confinement is realized by employing charge transport layers with high triplet energy, leading to a maximum external quantum efficiency of (19±1)%. Using the p-i-n device structure, we have achieved a peak power efficiency of (40±2) lm/W and (36±2) lm/W at 100 cd/m2, a color rendering index of 79, and Commission Internationale de L’Eclairage coordinates of (0.37, 0.40) for the white light emission.
A Novel Practical Method to Classify Scholars Based on Research Subjects (2016)

We develop a practical technique in this paper to classify the scholars in different disciplines, organizations according to their research interests. The scholar classification is important to the scholars, research organizations,, government for research, evaluation, education, research resource allocation. It becomes really difficult because name abbreviation, interdisciplinary, especially tautonym for Chinese scholars. The scholar classification can be achieved by the publications, journals that they published with, keywords in their publications using big-data techniques.
Robust, long-term control of an electrocorticographic brain-computer interface with fixed parameters (2009)

All previous multiple-day brain-computer interface (BCI) experiments have dynamically adjusted the parameterization between the signals measured from the brain and the features used to control the interface. The authors present the results of a multiple-day electrocorticographic (ECoG) BCI experiment. A patient with a subdural electrode array implanted for seizure localization performed tongue motor tasks. After an initial screening and feature selection on the 1st day, 5 consecutive days of cursor-based feedback were performed with a fixed parameterization. Control of the interface was robust throughout all days, with performance increasing to a stable state in which high-frequency ECoG signal could immediately be translated into cursor control. These findings demonstrate that ECoG-based BCIs can be implemented for multiple-day control without the necessity for sophisticated retraining and adaptation.
The composition of sleep-promoting factor isolated from human urine. (1982)

A sleep-promoting substance, Factor S, has been extracted and purified from large volumes of human urine. Urinary Factor S is a small glycopeptide; amino acid-amino sugar analyses of the purified material revealed a substance composed of glutamic acid, alanine, diaminopimelic acid, and muramic acid in molar ratios of 2:2:1:1. The active glycopeptide resembles bacterial peptidoglycans but the composition suggests that it is not simply of adventitious origin. Other reasons for this conclusion are also given. Infusions into the lateral ventricle of the brain of about 5 pmol/kg of body weight induce a 50% increase in slow wave sleep in rabbits. The excess sleep is normal as judged by electrophysiological and behavioral criteria; it resembles the deep sleep that occurs when animals are allowed to sleep following prolonged sleep deprivation.
The Shapes and Sizes of Seeds (1970)

▪ Abstract The literature on effects of habitat fragmentation on biodiversity is huge. It is also very diverse, with different authors measuring fragmentation in different ways and, as a consequence, drawing different conclusions regarding both the ...Read More
Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats (2009)

Results from this study may imply that GA could counteract the development of visceral obesity and improve dyslipidaemia via selective induction of tissue LPL expression and a positive shift in serum lipid parameters respectively, and retard the development of IR associated with tissue steatosis.