gebhart/patrepeval huggingface dataset:
NAVIGATE I: Randomized, Placebo-Controlled, Double-Blind Trial of the Exhalation Delivery System With Fluticasone for Chronic Rhinosinusitis With Nasal Polyps (2018)

In patients with chronic rhinosinusitis with NP (CRSwNP) who were symptomatic despite high rates of prior intranasal steroid use and/or surgery, EDS-FLU produced statistically significant and clinically meaningful improvements compared to EDS-placebo in multiple subjective and objective outcomes (symptoms, SNOT-22, RSDI, SF-36, PGIC, and NP grade), including all 4 cardinal symptoms of CRSwNP.
Hypoxia-inducible Factor-1-dependent Overexpression of Myeloid Cell Factor-1 Protects Hypoxic Cells against tert-Butyl Hydroperoxide-induced Apoptosis (2004)

Increased levels of Mcl-1 (myeloid cell factor-1) have been reported in several cancers, suggesting an important role played by Mcl-1 in cancer cell survival. Mcl-1 is an anti-apoptotic protein shown to delay or block apoptosis. In this work, using semiquantitative immunofluorescence, real-time PCR, and RNase protection assay, an increase in Mcl-1 expression was detected in hepatoma HepG2 cells incubated under hypoxia or in the presence of cobalt chloride. Through analysis of the Mcl-1 promoter sequence, a putative HIF-1 (hypoxiainducible factor-1) binding site was identified. A Mcl-1 promoter fragment containing this hypoxia-responsive element was able to bind HIF-1 in vitro. It also induced hypoxia-dependent transcription of a luciferase reporter gene, which was suppressed by anti-HIF-1alpha short interfering RNA. Finally, overexpression of Mcl-1 protected HepG2 cells against apoptosis induced by tert-butyl hydroperoxide as shown by inhibition of caspase-3 activation and DNA fragmentation. All these data suggest a potential anti-apoptotic role of HIF-1 that could protect cells against apoptosis under hypoxia by overexpression of the Mcl-1 protein.
Development of a valid and reliable seven emotions impairment questionnaire and assessment of its predictability for phlegm and blood stasis (2016)

Based on our results, we concluded that the SEIQ is a reliable and valid instrument for evaluating SEI, and is strongly predictive of Phlegm and BS.
Molecular genetics of prion diseases in France (1994)

Human prion diseases are characterized by the accumulation in the brain of an abnormal form of the prion protein. Prion protein polymorphisms seem to play a key role in the pathogenesis of these diseases, probably by enhancing the amyloidogenic properties of the protein. We performed prion protein gene (PRNP) coding sequence analysis in 57 French subjects with Creutzfeldt-Jakob disease (CJD) and found a mutation of the PRNP coding sequence in nine subjects (15.8%); the mutation corresponded with a known family history of CJD in only three of these subjects. In 41 definite and probable cases without known PRNP mutations, codon 129 genotyping revealed an excess of the homozygous 129Met/Met genotype corresponding to a 3.4-fold increased risk of developing CJD when compared with the two other genotypes. We also found that the 129Val/Val genotype, which mainly governs susceptibility to iatrogenic CJD, does not seem to predispose to sporadic CJD.
Selection of Aminoglycoside-Resistant Variants of Pseudomonas aeruginosa in an in Vivo Model (1982)

The therapeutic failure of aminoglycosides in leukopenic mice was studied. Pseudomonas aeruginosa isolated from experimentally infected leukopenic mice was analyzed for susceptibility to gentamicin. Bacterial population analyses were performed before, during, and after therapy with high doses of gentamicin. Inocula from numerous strains, including P. aeruginosa strain ATCC 27853, harbored slowly growing aminoglycoside-resistant subpopulations. In leukopenic mice (in contrast to normal mice) receiving gentamicin, the breakthrough growth of these subpopulations occurred 6 hr after treatment. Resistance to gentamicin reversed in vivo when gentamicin treatment was stopped. The emergence of gentamicin-resistant subpopulations was successfully suppressed by a combined treatment regimen of gentamicin and ticarcillin. Gentamicin-ticarcillin synergy in these infections is due, in part, to antimicrobial suppression of slowly growing aminoglycoside-resistant subpopulations of bacteria.
Glutathione S-Transferase P1 Correlated with Oxidative Stress in Hepatocellular Carcinoma (2013)

We demonstrated that the reduced GSTP1 expression might contribute to oxidative stress in the development of HCC from CHB.
Carrier detection in non-deletional Duchenne/Becker muscular dystrophy families using polymorphic dinucleotide (CA) repeat loci of dystrophin gene. (2001)

Our study suggested that at least 6 STR markers spanning 5', central and 3' regions of the dystrophin gene are essential to ascertain one or more informative loci and to rule out recombinations in non-deletional D/BMD families for carrier analysis.
The evolving philosophers problem: dynamic change management (1990)

A model for dynamic change management which separates structural concerns from component application concerns is presented. This separation of concerns permits the formulation of general structural rules for change at the configuration level without the need to consider application state, and the specification of application component actions without prior knowledge of the actual structural changes which may be introduced. In addition, the changes can be applied in such a way so as to leave the modified system in a consistent state, and cause no disturbance to the unaffected part of the operational system. The model is applied to an example problem, 'evolving philosophers'. The principles of this model have been implemented and tested in the Conic environment for distributed systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Transcutaneous oxygen measurements predict healing of leg wounds with hyperbaric therapy (1996)

Twenty-six patients with chronic leg wounds had transcutaneous oxygen measurements taken from the peri-wound area and a chest reference site before undergoing hyperbaric oxygen therapy in order to evaluate the utility of transcutaneous oxygen measurements in predicting the response of wounds to hyperbaric therapy. Wound scores and wound areas were determined before treatment and after 10 hyperbaric exposures. Patients whose wounds averaged a 5% or greater reduction in wound score per treatment were designated "responders." Nine patients' wounds exhibited at least a 5% reduction in wound score per treatment. There were no differences observed between responders and the 17 nonresponders in age, duration of the wound, initial wound area, initial wound score, or in wound or reference transcutaneous oxygen measurements. Responders required significantly fewer treatments to achieve wound closure than did nonresponders. Peri-wound transcutaneous oxygen pressure when the patient was exposed to 2.4 atmospheres absolute correlated directly with the improvement in wound score per treatment (r = 0.64, p = 0.03). An inverse correlation was noted between surface peri-wound transcutaneous oxygen pressure and improvement in wound score per treatment (r = -0.74, p = 0.006). Elevated peri-wound transcutaneous oxygen measurements at 2.4 atmospheres absolute and reduced peri-wound oxygen measurements at 1 atmosphere absolute were associated with a more rapid response to hyperbaric oxygen treatments in patients with chronic leg wounds. The use of these measurements should allow this expensive and time-consuming therapy to be limited to those patients most likely to benefit.
Digital holographic multi-focus quantitative phase contrast microscopy (2008)

A modular setup for digital holography microscopy that allows non-destructive, marker free and quantitative high resolution full field measurements of transparent objects is described. The applied reconstruction algorithms enable the reconstruction of multiple image planes. Results from investigations of biological specimen show the systems applicability for numerical focus tracking and quantitative 3d life cell imaging. 1
MAP Kinase Kinase Kinase (MAPKKK)-dependent and -independent Activation of Sty1 Stress MAPK in Fission Yeast* (2010)

In fission yeast, the Sty1/Spc1/Phh1 mitogen-activated protein kinase (MAPK) pathway is known to be involved in multiple-stress responses. It is currently thought that the Sty1 MAPK cascade is mediated by histidine kinases and phosphorelay proteins in response to oxidative stress signals. However, studies of the exact transduction mechanism of multiple-stress responses are lacking. Thus, in response to various stimuli, we monitored the Sty1 MAPK pathway through the downstream transcription factor Atf1 in living cells using a highly sensitive luciferase reporter gene. Surprisingly, in cadmium and low glucose (LG) medium, Atf1 activation was observed even in the absence of all of the four fission yeast MAPK kinase kinases (MAPKKKs); whereas in osmotic stress, Atf1 activation was abolished. Thus, the osmotic stress likely mediates the MAPK activation via MAPKKKs, whereas a cadmium or LG condition activates the MAPK in a MAPKKK-independent manner. On the other hand, knockout of tyrosine phosphatase gene pyp1(+) abolished the Atf1 response to cadmium and LG, but not to osmotic stress, suggesting that Pyp1 is a sensor for cadmium and LG.
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020)

A substantial body of evidence supports that the gut microbiota plays a pivotal role in the regulation of metabolic, endocrine and immune functions. In recent years, there has been growing recognition of the involvement of the gut microbiota in the modulation of multiple neurochemical pathways through the highly interconnected gut-brain axis. Although amazing scientific breakthroughs over the last few years have expanded our knowledge on the communication between microbes and their hosts, the underpinnings of microbiota-gut-brain crosstalk remain to be determined. Short-chain fatty acids (SCFAs), the main metabolites produced in the colon by bacterial fermentation of dietary fibers and resistant starch, are speculated to play a key role in neuro-immunoendocrine regulation. However, the underlying mechanisms through which SCFAs might influence brain physiology and behavior have not been fully elucidated. In this review, we outline the current knowledge about the involvement of SCFAs in microbiota-gut-brain interactions. We also highlight how the development of future treatments for central nervous system (CNS) disorders can take advantage of the intimate and mutual interactions of the gut microbiota with the brain by exploring the role of SCFAs in the regulation of neuro-immunoendocrine function.
Question-Answer Driven Semantic Role Labeling: Using Natural Language to Annotate Natural Language (2015)

This paper introduces the task of questionanswer driven semantic role labeling (QA-SRL), where question-answer pairs are used to represent predicate-argument structure. For example, the verb "introduce" in the previous sentence would be labeled with the questions "What is introduced?", and "What introduces something?", each paired with the phrase from the sentence that gives the correct answer. Posing the problem this way allows the questions themselves to define the set of possible roles, without the need for predefined frame or thematic role ontologies. It also allows for scalable data collection by annotators with very little training and no linguistic expertise. We gather data in two domains, newswire text and Wikipedia articles, and introduce simple classifierbased models for predicting which questions to ask and what their answers should be. Our results show that non-expert annotators can produce high quality QA-SRL data, and also establish baseline performance levels for future work on this task.
Tailoring distributed acoustic sensing techniques for the microseismic monitoring of future CCS sites: Results from the field (2017)

Distributed Acoustic Sensing (DAS) is an emerging technology with great potential for microseismic monitoring of induced seismicity. Despite this potential and the advantages it presents over conventional geophone arrays, challenges remain regarding geometrical sensitivity and noise-floors. Furthermore, there has been little application of DAS systems at Carbon Capture and Storage (CCS) injection sites. Here, we present the results of hammer blow field experiments, in subzero conditions using a single cable DAS recording setup. We test different data processing routines and compute Signal to Noise Ratios (SNRs) in the time and frequency domains. We find that most energy is observed in the 20-600 Hz band and that SNR ratios are approximately half those of geophones, which record simultaneously. An STA/LTA automated trigger detection routine performs well for the majority of the DAS recording channels but with some detections not defining the expected hyperbolic move-out with distance for common arrivals. These likely represent later, secondary arrival phases, possibly reflections from the frozen-unfrozen ground interface. Despite this, using a single homogenous velocity model it is possible to locate the hammer blows to within 3.9 m of their actual locations. These encouraging initial results will be used to tailor the setup and acquisition parameters in further field and laboratory tests. This will ultimately lead to the pre-injection site characterization and subsequent microseismic monitoring of active CCS sites in the future. Presentation Date: Monday, September 25, 2017 Start Time: 3:55 PM Location: 362D Presentation Type: ORAL
Comparison of on-line and off-line liquid chromatography/nuclear magnetic resonance spectrometry for analysis of steroid mixtures (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of on-line and off-line liquid chromatography/nuclear magnetic resonance spectrometry for analysis of steroid mixturesJoachim. Buddrus and Helmut. HerzogCite this: Anal. Chem. 1983, 55, 9, 1611–1614Publication Date (Print):August 1, 1983Publication History Published online1 May 2002Published inissue 1 August 1983https://pubs.acs.org/doi/10.1021/ac00260a040https://doi.org/10.1021/ac00260a040research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modified CNN model-based Forgery Detection applied to Multiple-Resolution Tampered Images (2021)

The crucial problem of forensic techniquesis is how to detect/recognize tampered images through public media platforms under the attactks of subjective modifications. Because of many accessible photoshop programs, an image/video such as in Facebook, Instagram, Reddit Twitter, etc. can be easily tampered to falsify the information within the image. Accoding to the requirement of an efficient method for detecting fake images, we have developed modifed CNN models which are combined with the super-resolution approach to solve this issue. In the paper, we present an appropriate method using CNN models to detect tampered images with the increase in resolutions of the tampered areas, the proposed model can detect and point out the areas that have been tampered. The ResNet50 and mUNet modified models are used for classification and segmentation respectively. With the developed models, the results were given with an accuracy of at least 90% on the evaluation sets.
Effective VM sizing in virtualized data centers (2011)

In this paper, we undertake the problem of server consolidation in virtualized data centers from the perspective of approximation algorithms. We formulate server consolidation as a stochastic bin packing problem, where the server capacity and an allowed server overflow probability p are given, and the objective is to assign VMs to as few physical servers as possible, and the probability that the aggregated load of a physical server exceeds the server capacity is at most p.
Leptin Infusion and Obesity in Mouse Cause Alterations in the Hypothalamic Melanocortin System (2008)

The objectives of this study were to identify potential alterations in gene expression of melanocortin-4 receptor (MC4-R), proopiomelanocortin (POMC), and Agouti-related protein (AgRP) in mouse hypothalamus under a chronic peripheral infusion of leptin or at early (8 weeks) and advanced (16 weeks) phases of diet-induced obesity. Control or diet-induced obesity mice (8 or 16 weeks of high-fat diet) were either treated or not treated with leptin. Metabolic features were analyzed and expression of the genes of interest was measured by quantitative reverse transcriptase-PCR (RT-qPCR) and western blot. We reported that in control mice, but not in obese mice, leptin infusion induced an increase in POMC mRNA level as well as in MC4-R mRNA level suggesting that leptin could act directly and/or through alpha-melanocyte-stimulating hormone (alpha-MSH). This hypothesis was reinforced after in vitro studies, using the mouse hypothalamic GT1-7 cell line, since both leptin and Norleucine(4), D-Phenylalanine(7)-alpha-MSH (NDP-alpha-MSH) treatments increased MC4-R expression. After 8 weeks of high-fat diet, nondiabetic obese mice became resistant to the central action of leptin and their hypothalamic content of POMC and AgRP mRNA were decreased without modification of MC4-R mRNA level. After 16 weeks of high-fat diet, mice exhibited more severe metabolic disorders with type 2 diabetes. Moreover, hypothalamic expression of MC4-R was highly increased. In conclusion, several alterations of the melanocortin system were found in obese mice that are probably consecutive to their central resistance to leptin. Moreover, when the metabolic status is highly degraded (with all characteristics of a type 2 diabetes), other regulatory mechanisms (independent of leptin) can also take place.
E2F mediates enhanced alternative polyadenylation in proliferation (2012)

Our results comprehensively identify alternative polyadenylation events associated with cellular proliferation and transformation, and demonstrate that the enhanced alternative polyadenylation in proliferative conditions results not only in global 3' UTR shortening but also in enhanced premature cleavage in introns. Our results also indicate that E2F-mediated co-transcriptional regulation of 3'-end processing genes is one of the mechanisms that links enhanced alternative polyadenylation to proliferation.
Video coding using the most common frame in scene (2010)

Motion estimation (ME) and motion compensation (MC) using variable block size, fractional search, and multiple reference frames (MRFs) help the recent video coding standard H.264 to improve the coding performance significantly over the other contemporary coding standards. The concept of MRF achieves better coding performance in the cases of repetitive motion, uncovered background, non-integer pixel displacement, lighting change, etc. The requirement of index codes of the reference frames, computational time in ME&MC, and memory buffer for pre-coded frames limits the number of reference frames used in practical applications. In typical video sequence, the previous frame is used as a reference frame with 68~92% of cases. In this paper, we propose a new video coding method using a reference frame (i.e., the most common frame in scene (McFIS)) generated by the Gaussian mixture based dynamic background modelling. The McFIS is not only more effective in terms of rate-distortion and computational time performance compared to the MRFs but also error resilient transmission channel. The experimental results show that the proposed coding scheme outperforms the H.264 standard video coding with five reference frames by at least 0.5 dB and reduced 60% of computation time.
Simultaneous incorporation of three different modified nucleotides during PCR (2003)

Modified analogs of 2'-deoxycytidine triphosphates bearing (6-aminohexyl)carbamoylmethyl or 7-amino-2,5-dioxaheptyl linker at a C5 position were designed and synthesized. Both analogs were found to be good substrates for Vent(exo-) DNA polymerase during PCR, resulting in the corresponding full-length modified DNAs, respectively. Moreover, we have demonstrated simultaneous incorporation of three different modified nucleotides into a DNA strand by PCR using triphosphates of 5-(3-aminopropynyl)dUTP, 5-[(6-aminohexyl)carbamoylmethyl]dCTP and 2-amino-dATP (dDTP) or N6-methyl-dATP in place of the natural nucleoside triphosphates TTP, dCTP and dATP.
What causes autism? Exploring the environmental contribution (2010)

Expanded research is needed into environmental causation of autism. Children today are surrounded by thousands of synthetic chemicals. Two hundred of them are neurotoxic in adult humans, and 1000 more in laboratory models. Yet fewer than 20% of high-volume chemicals have been tested for neurodevelopmental toxicity. I propose a targeted discovery strategy focused on suspect chemicals, which combines expanded toxicological screening, neurobiological research and prospective epidemiological studies.
The effectiveness of novel chlorine dioxide in drinking water disinfection (2020)

ABSTRACT: The presence of <em>E. coli</em> in drinking water is not very common, however drinking water polluted with <em>E. coli</em> can lead to infection and could cause serious illness. Water contamination can lead to adverse health effects, including gastrointestinal illness, reproductive problems, and neurological disorders. More than 200 diseases are derived from polluted water. The main objective of present research was to evaluate the effectiveness of novel chlorine dioxide for the inactivation of <em>E. coli</em> in drinking water. Chlorine dioxide is made of two compounds: liquid sodium chlorite and solid sodium-peroxodisulphate »in situ«. Chlorine dioxide composition is in accordance with water treatment regulation [1]. In this experiment, different concentrations of chlorine dioxide were added at different temperatures in order to determine the optimal conditions for <em>E. coli</em> removal from drinking water. Results showed that optimal dose is 0.2 mg/L of chlorine dioxide at room temperature, while the same dose was effective at increased temperatures at 30 °C and 40 °C. The contact time was less than 1 min.
Phone-based CSCW (1993)

Telephones are the most ubiquitous, best-networked, and simplest computer terminals available today. They have been used for voice mail but largely overlooked as a platform for asynchronous cooperative-work applications such as event calendars, issue discussions, and question-and-answer gathering. HyperVoice is a software toolkit for constructing such applications. Its building blocks are high-level presentation formats for collections of structured voice messages. The presentation formats can themselves be presented and manipulated, enabling significant customization of applications by phone. Results of two field trials suggest social-context factors that will influence the success or failure of phone-based cooperative work applications in particular settings.