gebhart/patrepeval huggingface dataset:
APOYA LA SOCIEDAD DE EXALUMNOS DE ARQUITECTURA LA VINCULACIÓN CON LOS SECTORES PRODUCTIVOS (2000)

DURANTE LA ASAMBLEA GENERAL ORDINARIA DE LA SOCIEDAD DE EXALUMNOS DE LA FACULTAD DE ARQUITECTURA (FASE, AC), EFECTUADA EL 1 DE JUNIO, EL CONSEJO DE ADMINISTRACION Y VIGILANCIA DE DICHA AGRUPACION TOMO POSESION PARA EL PERIODO 2000-2002. EN PRESENCIA DE FRANCISCO RAMOS, ENCARGADO DE LA SECRETARIA DE LA RECTORIA, QUIEN ASISTIO EN REPRESENTACION DEL RECTOR JUAN RAMON DE LA FUENTE, EL PRESIDENTE ENTRANTE DEL CONSEJO, FERNANDO ISLAS RAMIREZ, DIJO QUE LA ASOCIACION OFRECE ESPACIOS PARA QUE SUS INTEGRANTES PUEDAN DESPLEGAR ACCIONES CONCRETAS Y ACTITUDES SOLIDARIAS EN FAVOR DE LA UNIVERSIDAD NACIONAL. FRANCISCO RAMOS MENCIONO QUE LA UNIVERSIDAD ESPERA EL APOYO DE SUS EGRESADOS, PARTICULARMENTE EN LOS ULTIMOS MESES Y EN ESTOS MOMENTOS EN QUE LA INSTITUCION REGRESA PAULATINAMENTE A SU NORMALIDAD. FELIPE LEAL, DIRECTOR DE LA FACULTAD DE ARQUITECTURA Y PRESIDENTE HONORARIO DE LA SOCIEDAD DE EXALUMNOS, SENALO QUE EL PAPEL DE LOS EGRESADOS ES DE UN ENORME COMPROMISO PARA ENCONTRAR ALTERNATIVAS DE SOLUCION A LOS PROBLEMAS QUE ENFRENTA LA UNIVERSIDAD. EN EL ACTO, CELEBRADO EN EL AULA ENRIQUE DEL MORAL DE LA FA, FUERON NOMBRADOS SECRETARIO GENERAL Y TESORERA DEL CONSEJO, ARMANDO GARCIA BURGUENO Y ELODIA GOMEZ MAQUEO.
Unusual Transformation of the Mechanically Induced Monodomain State to the Polydomain One in Polar Nematic Liquid Crystals of Aromatic Polyesters (2009)

We present an interesting phenomenon of the mechanically aligned monodomain state of polar nematic liquid crystals transforming into the polydomain one. This unusual transformation may result from mismatching of the dipolar vectors. By stretching or shear-flowing the polar nematic liquid crystal, the perfect orientation can be achieved with respect to the long molecular axis, but the misorientation exists with respect to the polar vector. After the prolonged annealing, then, the free energy of the molecules is minimized by producing new defects which satisfy the continuity of polar orientation, but lead to the loss of macroscopic molecular orientation.
Hypothalamic-Pituitary-Adrenal Reactivity in Boys with Attention Deficit Hyperactivity Disorder (2003)

The hypothesis 'whether subjects with attention-deficit/ hyperactivity disorder (ADHD), who showed under-reactivity of the hypothalamic-pituitary-adrenal (HPA) axis to stress, would make more commission errors in attention tasks', was examined. Forty-three boys, with ADHD, who visited the psychiatric outpatient clinic, at Kangbuk Samsung Hospital, were the subjects of this study. Both pre- and post-test morning saliva samples were collected from the patients at the Korean Educational Development Institute-Wechsler Intelligence Scale for Children (KEDI-WISC), and Tests of Variables of Attention (T.O.V.A.) performed. The Standard scores of the T.O.V.A were compared between the patients with decreases, or increases, in the salivary cortisol levels after the test. Decreases, or increases in the salivary cortisol levels after the test were shown in 28 and 15 patients, respectively. The patients with decreased cortisol levels after the test tended to make more commission errors in compared with those with increased cortisol levels. The patients with the decreased cortisol levels after test had more omission errors in the first quarter of the test, and more commission errors in the second half of the test compared to those with the increased cotisol levels. Subjects who show decreased salivary cortisol levels after stress make more commission errors in attention tests. This suggests that the blunted HPA axis response to stress is related to the impulsivity in patients with ADHD.
Mechanisms of plaque rupture mechanical and biologic interactions (1999)

Atherosclerotic vascular disease is the most common cause of morbidity and mortality in developed countries, and the world-wide importance of acute vascular syndromes is increasing. Acute events are usually triggered by the development of plaque disruption and subsequent thrombus formation. Histological studies have established specific structural features common among unstable plaques. The plaque has to bear remarkably increased mechanical stress at particular regions, and weakening of the extracellular matrix at these sites leads to fibrous cap rupture. The biologic factors that cause weakening of the plaque at these high stress locations are now emerging. Understanding the interplay of plaque architecture, mechanical properties and matrix biology is critical in the future development of therapies to stabilize lesions.
MET Activation Mediates Resistance to Lapatinib Inhibition of <i>HER2</i> -Amplified Gastric Cancer Cells (2012)

HER2 amplification is found in more than 15% of gastric cancers and is associated with poor clinical outcome. Lapatinib, a dual HER2 and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has shown promising in vitro results in treating HER2(+) cancer cells. However, several studies have shown that activation of alternative receptor tyrosine kinases can mediate resistance to HER-targeted therapy. Here, we investigated whether activated MET can confer resistance to lapatinib inhibition of gastric cancer cells. A panel of gastric cancer cell lines was treated with lapatinib, and we observed that cell proliferation was reduced by 70% and that the degree of HER2 amplification corresponds to sensitivity to lapatinib. Immunoblotting analysis indicated that phosphorylation of HER2, EGFR, MET, AKT, and extracellular signal-regulated kinase was inhibited by lapatinib and presumably led to cell-cycle arrest as observed with flow cytometry. Hepatocyte growth factor (HGF) activation of MET receptors rescued cells from lapatinib-induced growth inhibition by restimulating the downstream pathways and restoring normal cell-cycle progression. This rescue effect could be abrogated by inhibiting MET with PHA-665752 (a highly specific MET inhibitor) or downregulating MET expression with short interfering RNA. No synergy in growth inhibition was observed when cells were treated with a combination of lapatinib and PHA-665752. Repeat studies using insulin-like growth factor 1 and fibroblast growth factor 3 could not uniformly rescue the lapatinib-treated gastric cancer cells. In conclusion, HGF/MET-mediated resistance to lapatinib is a novel mechanism of resistance to HER2-targeted agents in gastric cancer cells. Development of inhibitors targeting multiple receptors or common downstream signaling proteins merits further investigation.
Development and In Vitro Evaluation of Surface Modified Poly(lactide-co-glycolide) Nanoparticles with Chitosan-4-Thiobutylamidine (2007)

The objective of this study was to develop a nanoparticulate drug delivery system based on the surface modification of poly(lactide-co-glycolide) (PLGA) nanoparticles with a thiolated chitosan. PLGA nanoparticles were prepared by the emulsification-solvent evaporation method. Immobilization of chitosan to the surface of PLGA nanoparticles via amide bonds was mediated by a carbodiimide. Thiol groups were covalently bound to the chitosan surface of particles by reaction with 2-iminothiolane. Obtained nanoparticles were characterized in vitro regarding size, zeta potential, thiol group content, stability at different pH values, mucoadhesion, and drug release. Results demonstrated that the surface modification of PLGA nanoparticles with thiolated chitosan (chitosan-TBA) leads to nanoparticles of a mean diameter of 889.5 +/- 72 nm and positive zeta potential of + 24.74 mV. The modified nanoparticles contained 7.32 +/- 0.24 micromol thiol groups per gram nanoparticles. The size of nanoparticles was strongly influenced by the pH of the surrounding medium, being 925.0 +/- 76.3 nm at pH 2 and 577.8 +/- 66.7 nm at pH 7.4. Thiolated nanoparticles showed a 3.3-fold prolonged residence time on the mucosa and an unchanged release profile in comparison to unmodified PLGA nanoparticles. These data suggest that surface modified chitosan-TBA conjugate PLGA nanoparticles have the potential to be used as mucoadhesive drug delivery system.
ChemInform Abstract: LIGAND STRUCTURE AND COMPLEXATION, XXII. 2,6‐BIS(AMINOMETHYL)PYRIDINE AS A COMPLEX LIGAND AND NEW BUILDING BLOCK FOR CROWN ETHER SYNTHESIS (1978)

Abstract Aus dem Pyridin (Ia) wird nach der üblichen Gabriel‐Methode über das Phthalimid (Ib) die Titelverbindung (Ic) erhalten, die bereits kristalline Komplexe mit z.B. CuCl" Ni(BF 4 ), und Mg(ClO 4 ), bildet.
The Effect of Paclitaxel Powder on Glaucoma Filtration Surgery in Rabbits (1998)

The introduction of paclitaxel into the subconjunctival space at the conclusion of filtration surgery has an effect comparable to intraoperative MMC.
Optical Testing of the AWARE Wide Field 2-Gigapixel Multiscale Camera (2011)

Testing a 2-Gigapixel 8 arcsec IFOV, 120° FOV camera requires integration of precision mechanical automation, optical instrumentation, image diagnostics, electronics and networking hardware. We detail the ongoing AWARE Wide Field Camera efforts.
A Randomized Double-Blind Crossover Trial of Triventricular versus Biventricular Pacing in Heart Failure (2012)

TriV pacing was associated with significant improvements in clinical and echocardiographic parameters compared with BiV pacing.
Melanin and fungi (2003)

Melanin has been referred to as 'fungal armor' due to the ability of the polymer to protect microorganisms against a broad range of toxic insults. Recent publications continue to reveal important contributions of melanin to survival of fungi in the environment and during infection.
A Coreflood Investigation of Nanofluid Enhanced Oil Recovery in Low-Medium Permeability Berea Sandstone (2013)

Abstract Nanoparticles have become an attractive agent for improved and enhanced oil recovery (IOR & EOR) at laboratory scale recently. Most researchers have observed promising result and increased ultimate oil recovery by injecting nanofluids in laboratory experiments. In previous study, we observed that interfacial tensions (IFT) decreased when hydrophilic nanoparticles were introduced to brine. The IFT decreases as nanofluids concentration increase and this indicates a potential for EOR. We have also investigated nanofluid flow in glass micromodel and high permeability Berea sandstone (ss) cores, and we observed that the higher concentration of nanofluids; the more impairment of porosity and permeability. Since low permeability oil reservoirs have still huge volume of oil reserves, this study aims to reveal nanofluids possibility for EOR in low-medium permeability reservoir rocks and investigate its suitable concentration. In this paper, laboratory coreflood experiments were performed in water-wet Berea ss core plugs with permeability in range 9- 35 mD using different concentrations of nanofluids. Three nanofluids concentrations were synthesized with synthetic brine; 0.01, 0.05 and 0.1 wt.%. To investigate disjoining pressure as displacement mechanism due to nanoparticles, contact angle between crude oil from a field in the North Sea and brine/nanofluids have been measured. Increasing hydrophilic nanoparticles will decrease contact angle of aqueous phase and increase water-wetness. Despite increasing nanofluid concentration shows decreasing IFT and altering wettability, our results indicate that additional recovery is not guaranteed. The processes and results are outlined and also further detailed in the paper to reveal the possible application of nanofluid EOR in lower-medium permeability oil reservoir.
Demonstration of Stroboscopic X-ray Talbot Interferometry Using Polychromatic Synchrotron and Laboratory X-ray Sources (2013)

Stroboscopic X-ray Talbot interferometry that is applicable to time-resolved quantitative X-ray phase imaging of periodic processes in soft materials is demonstrated. The constraint in photon flux was overcome by employing the stroboscopic technique of repeatedly capturing an image of the object at a specific phase of motion and by using polychromatic X-ray sources. By utilizing white synchrotron radiation in conjunction with a high-speed CMOS camera, stroboscopic X-ray Talbot interferometry with a 3 µs temporal resolution was achieved. By incorporating a chopper into a laboratory X-ray Talbot–Lau interferometer, a 5 ms temporal resolution was achieved.
The biological and physical chemistry of polyhydroxyalkanoates as seen by NMR spectroscopy (1992)

The use of 13C NMR spectroscopy to study the biosynthesis, degradation and physical properties of polyhydroxyallkanoates (PHAs) is described. Solution-state NMR of whole cells allows direct observation of biosynthetic pathways within the cell and demonstrates that the bulk of the polymer is in a remarkably fluid, amorphous state. A new model is proposed for the maintenance of this state in vivo: the known rate of crystal nucleation combined with the physical dimensions of the native PHA granule lead naturally to the conclusion that polymer morphology is under kinetic rather than thermodynamic control. Finally solid-state NMR studies of isolated PHAs allow observation of separate crystalline regions based on hydroxybutyrate and hydroxyvalerate and measurement of the HB and HV contents of these and amorphous domains.
비만캠프에 참여한 남녀 초등학생의 신체조성, 신체활동량, 체력 및 지질대사의 비교분석 (2013)

본 연구는 2박 3일 비만캠프에 참여한 초등학생의 남녀별 신체조성, 신체활동 량, 체력 및 지질대사를 비교분석하여 캠프를 참여하는데 있어 남녀 초등학생의 프로그램 참여의 차별성을 이해하는데 목적이 있다. 비만캠프에 참여한 초등학생 30명(남자: 16명, 여자: 14명)을 대상으로 신체조성, 신체활동량, 체력 및 지질대사를 분석한 결과는 다음과 같다. 신체조성의 경우 남학생은 체질량지수와 체지방율이, 여학생은 체지방율이 유의한 차이를 보였다. 신체활동량의 경우 일일평균 총소비 량이 유의 하진 않았으나, 의 미 있는 차이를 보였다(p=.056). 체력 은 여 학생의 경우 좌전굴이, 남학생의 경우 50m달리기, 제자리멀리뛰기에서 유의한 차이를 보였다. 지질대사의 경우 남녀별 유의한 차이는 없었다. 본 연구 결과 비만캠프에서 실시하고 있는 운동량은 체중조절에 도움이 되는 적정 운동량인 것으로 판정되었으며, 프로그램을 진행하는데 있어, 신체활동량을 증진시키기 위 하여 여학생의 좀 더 적극적인 참여를 유도하는 것이 중요하다고 판단된다. 특히 운동프로그램 계획시 여학생의 체력을 고려하여 진행되어야 할 것으로 사료 된다.
Deep brain stimulation for Parkinson's disease: Patient selection and evaluation (2002)

Critical to the successful application of deep brain stimulation for the treatment Parkinson's disease is the proper selection of patients who will reliably benefit from this procedure and the successful evaluation of the responses obtained. This review will discuss the various factors influencing patient selection and summarize the recommended approach to patient assessment by using the Core Assessment Program for Surgical Interventions and Transplantation in Parkinson's Disease (CAPSIT-PD).
Serotonin 2B receptor is required for heart development (2000)

Several lines of evidence suggest that the serotonin (5-hydroxytryptamine, 5-HT) regulates cardiovascular functions during embryogenesis and adulthood. 5-HT binds to numerous cognate receptors to initiate its biological effects. However, none of the 5-HT receptor disruptions in mice have yet resulted in embryonic defects. Here we show that 5-HT(2B) receptor is an important regulator of cardiac development. We found that inactivation of 5-HT(2B) gene leads to embryonic and neonatal death caused by heart defects. 5-HT(2B) mutant embryos exhibit a lack of trabeculae in the heart and a specific reduction in the expression levels of a tyrosine kinase receptor, ErbB-2, leading to midgestation lethality. These in vivo data suggest that the Gq-coupled receptor 5-HT(2B) uses the signaling pathway of tyrosine kinase receptor ErbB-2 for cardiac differentiation. All surviving newborn mice display a severe ventricular hypoplasia caused by impaired proliferative capacity of myocytes. In adult mutant mice, cardiac histopathological changes including myocyte disarray and ventricular dilation were consistently observed. Our results constitute genetic evidence that 5-HT via 5-HT(2B) receptor regulates differentiation and proliferation of developing and adult heart. This mutation provides a genetic model for cardiopathy and should facilitate studies of both the pathogenesis and therapy of cardiac disorders in humans.
Prioritizing Parkinson’s disease genes using population-scale transcriptomic data (2019)

Genome-wide association studies (GWAS) have identified over 41 susceptibility loci associated with Parkinson's Disease (PD) but identifying putative causal genes and the underlying mechanisms remains challenging. Here, we leverage large-scale transcriptomic datasets to prioritize genes that are likely to affect PD by using a transcriptome-wide association study (TWAS) approach. Using this approach, we identify 66 gene associations whose predicted expression or splicing levels in dorsolateral prefrontal cortex (DLFPC) and peripheral monocytes are significantly associated with PD risk. We uncover many novel genes associated with PD but also novel mechanisms for known associations such as MAPT, for which we find that variation in exon 3 splicing explains the common genetic association. Genes identified in our analyses belong to the same or related pathways including lysosomal and innate immune function. Overall, our study provides a strong foundation for further mechanistic studies that will elucidate the molecular drivers of PD.
Angiotensin II Stimulates Endothelial NO Synthase Phosphorylation in Thoracic Aorta of Mice With Abdominal Aortic Banding Via Type 2 Receptor (2006)

Abdominal aortic banding in mice induces upregulation of angiotensin II (Ang II) type 2 (AT 2 ) receptors in the pressure-overloaded thoracic aorta. To clarify mechanisms underlying the vascular AT 2 receptor-dependent NO production, we measured aortic levels of endothelial NO synthase (eNOS), eNOS phosphorylated at Ser 633 and Ser 1177 , protein kinase B (Akt), and Akt phosphorylated at Ser 473 in thoracic aortas of mice after banding. Total eNOS, both forms of phosphorylated eNOS, Akt, and phosphorylated Akt levels, as well as cGMP contents, were significantly increased 4 days after banding. The administration of PD123319 (an AT 2 receptor antagonist) or icatibant (a bradykinin B 2 receptor antagonist) abolished the banding-induced upregulation of both forms of phosphorylated eNOS, as well as elevation of cGMP, but did not affect the upregulation of eNOS, Akt, and phosphorylated Akt. In the in vitro experiments using aortic rings prepared from banded mice, Ang II produced significant increases in both forms of phosphorylated eNOS, as well as cGMP, and these effects were blocked by PD123319 and icatibant. Ang II–induced eNOS phosphorylation and cGMP elevation in aortic rings were inhibited by protein kinase A (PKA) inhibitors H89 and KT5720 but not by phosphatidylinositol 3-kinase inhibitors wortmannin and LY24002. The contractile response to Ang II was attenuated in aortic rings from banded mice via AT 2 receptor, and this attenuation was blocked by PKA inhibitors. These results suggest that the activation of AT 2 receptor by Ang II induces phosphorylation of eNOS at Ser 633 and Ser 1177 via a PKA-mediated signaling pathway, resulting in sustained activation of eNOS.
On the transistor sizing problem (2002)

This paper introduces a new transistor sizing technique for timing optimization in a transistor level netlist. Starting from an initial solution, the widths of the transistors in the netlist are tuned iteratively to meet the specified timing constraints. Efficient heuristics to significantly improve the run time performance are outlined. The improvement of timing and area performance are demonstrated with several real circuits.
Outcome of intrathecal opioids in chronic non‐cancer pain (2001)

Eighty-eight patients (58 women and 30 men; mean age 53.4 years) with chronic non-cancer pain present on average for 9.8 years were evaluated following treatment with intrathecal opioids for an average duration of 36.2 months. Outcome measures were global pain relief, physical activity levels, medication consumption, work status, intrathecal opioid side-effects, proportion of patients who ceased therapy and patient satisfaction. The most common diagnosis in this group was lumbar spinal or radicular pain after failed spinal surgery (n= 55, 63%). At the time of follow-up, mean pain relief was 60% with 74% of patients (36 of 49) reporting increased activity levels. Oral medication intake was significantly reduced (Medication Quantification Scale Score prior to implantation 31.0+/-2.6 and at follow-up 12.7+/-1.4; n= 48; p< 0.0001). These gains were not accompanied by a change in work status (43 of 50 working age patients not working at follow-up). There were frequent reports of opioid side-effects, including sexual dysfunction and menstrual disturbance. Technical complications occurred with the drug administration device, most often catheter related, requiring at least one further surgical procedure in 32 patients (40%). Patient satisfaction with intrathecal opioids was high, with 45 of 51 (88%) reporting satisfaction. Mean intrathecal morphine dose increased from 9.95+/-1.49 mg/day (mean+/-SEM) at 6 months to 15.26+/-2.52 mg/day 36 months after initiation of therapy. Drug administration systems were permanently removed in five patients (6%). Intrathecal opioid therapy appears to have a place in the management of chronic non-cancer pain. Therapy does not seem to be significantly inhibited by the development of tolerance.
Bulk characterization methods for non-centrosymmetric materials: second-harmonic generation, piezoelectricity, pyroelectricity, and ferroelectricity (2006)

Characterization methods for bulk non-centrosymmetric compounds are described. These methods include second-harmonic generation, piezoelectricity, pyroelectricity, and ferroelectricity. In this tutorial review with each phenomenon, details are given of the measurement techniques along with a brief history and background. Finally, data interpretation is discussed.
Molecular cloning of human ornithine aminotransferase mRNA. (1986)

The isolation and characterization of a cDNA clone for the mRNA of human ornithine aminotransferase (OATase; ornithine-oxo-acid aminotransferase; L-ornithine:2-oxo-acid aminotransferase, EC 2.6.1.13), a nonabundant mitochondrial matrix enzyme that is severely deficient in a hereditary chorioretinal degenerative disease (gyrate atrophy), is described. Human liver, retina, and retinoblastoma (Y79) mRNAs were prepared and tested for the OATase mRNA content by in vitro translation, immunoprecipitation, and NaDodSO4/PAGE. The retinoblastoma cells were found to be expressing this enzyme at a relatively high level. The primary translation product of the OATase mRNA is larger than the pure OATase protein on NaDodSO4/PAGE by approximately equal to 4 kDa, suggesting a precursor protein. lambda gt11 cDNA libraries were prepared from the human mRNAs, and the recombinant clones were immunoscreened as plaques with two different preparations of rabbit anti-human OATase antibodies. A clone (lambda gtRB315) was isolated from the retinoblastoma library that reacts with both of the antibody preparations, and the DNA sequence of its 2.1-kilobase-pair cDNA insert was obtained. An open reading frame consisting of 1371 nucleotides is present in the sequence, and a putative translational initiation methionine codon is identified at position 55. A putative leader sequence consisting of 32 amino acid residues is identified, resulting in a precursor protein of 439 amino acid residues and a molecular mass of 48,534 Da and a mature protein of 407 residues and 45,136 Da. The amino acid sequences of seven tryptic peptides (115 amino acid residues) of the pure human OATase were obtained by microsequencing. When the tryptic peptide and cDNA-derived amino acid sequences were compared, homologies in 111 of 115 residues, including a match of 20 consecutive residues, were observed. An RNA blot hybridization of 32P-labeled OATase cDNA to normal human retina and retinoblastoma mRNAs demonstrated an OATase mRNA species of approximately equal to 2.2 kilobases. The level of OATase mRNA in the normal human retina is approximately equal to 1/100th the level of rhodopsin mRNA and 1/5th to 1/10th the level present in the retinoblastoma cells.