gebhart/patrepeval huggingface dataset:
Novel secreted isoform of adhesion molecule ICAM-4: potential regulator of membrane-associated ICAM-4 interactions (2003)

Intercellular adhesion molecule-4 (ICAM-4), a newly characterized adhesion molecule, is expressed early in human erythropoiesis and functions as a ligand for binding alpha4beta1 and alphaV integrin-expressing cells. Within the bone marrow, erythroblasts surround central macrophages forming erythroblastic islands. Evidence suggests that these islands are highly specialized subcompartments where cell adhesion events, in concert with cytokines, play critical roles in regulating erythropoiesis and apoptosis. Since erythroblasts express alpha4beta1 and ICAM-4 and macrophages exhibit alphaV, ICAM-4 is an attractive candidate for mediating cellular interactions within erythroblastic islands. To determine whether ICAM-4 binding properties are conserved across species, we first cloned and sequenced the murine homologue. The translated amino acid sequence showed 68% overall identity with human ICAM-4. Using recombinant murine ICAM-4 extracellular domains, we discovered that hematopoietic alpha4beta1- expressing HEL cells and nonhematopoietic alphaV-expressing FLY cells adhered to mouse ICAM-4. Cell adhesion studies showed that FLY and HEL cells bound to mouse and human proteins with similar avidity. These data strongly suggest conservation of integrin-binding properties across species. Importantly, we characterized a novel second splice cDNA that would be predicted to encode an ICAM-4 isoform, lacking the membrane-spanning domain. Erythroblasts express both isoforms of ICAM-4. COS-7 cells transfected with green flourescent protein constructs of prototypic or novel ICAM-4 cDNA showed different cellular localization patterns. Moreover, analysis of tissue culture medium revealed that the novel ICAM-4 cDNA encodes a secreted protein. We postulate that secretion of this newly described isoform, ICAM-4S, may modulate binding of membrane-associated ICAM-4 and could thus play a critical regulatory role in erythroblast molecular attachments.
The solid-state Ku-band power amplifier (1975)

A survey of IMPATT diodes and negative resistance amplifiers is presented. The first phase of the amplifier effort is discussed in which a single diode reflection amplifier delivering 0.5 watt at 15 GHz with 10-dB gain over a 1-GHz band was developed. The design of a dominant mode resonant combiner is described along with the characterization of the IMPATT diodes. Results are given on the complete amplifier and on the thermal and graceful failure characteristics of the unit.
Chemotherapy drug delivery from calcium phosphate nanoparticles. (2007)

Calcium phosphate nanoparticles (nanoCaP) conjugated with cis-diamminedichloroplatinum (CDDP, cisplatin) were prepared through the electrostatic binding of an aquated species of cisplatin to the nanoCaP in a chloride-free solution. The agglomeration of the nanoCaP that typically occurs during synthesis of CaP was controlled through the addition of DARVAN 811 immediately after precipitation and before drug conjugation. In vitro drug release studies were completed and showed a sustained release of CDDP from the nanoconjugates over time. The cytotoxicity of the nanoCaP/CDDP was compared to that of the free drug in an in vitro cell proliferation assay using the CDDP resistant A2780cis human ovarian cancer cell line. The CDDP released from the nanoconjugates was equally effective as the free drug against the A2780cis cell line. Direct addition cytotoxicity studies revealed that the sterically-stabilized, negatively-charged drug nanoconjugates are unable to overcome drug resistance and had an increased IC50 value as compared to the free drug.
Quality control and health monitoring of aerospace composites via quadrupole resonance (2005)

Techniques for quality control and health monitoring of aerospace composite structures must be reliable, nonintrusive and preferably, non-contacting. Quadrupole resonance (QR) spectroscopy can fill this need. Previously, we have demonstrated that Quadrupole Resonance can be used for nondestructive inspection of polymeric fiber-reinforced composites, which can be exploited for both in-service inspection and on-going structural health monitoring.1-6 In this paper we present an extension of this work, applying the QR method to the quality control of composite parts manufactured via pultrusion. In order to use the QR method for quality control of composite parts they must contain a small amount of tiny crystals of a QR active compound. These crystals are embedded in the part during the manufacture by blending it into the uncured resin. The QR active crystals sense any residual strains that may form inside the part during the manufacturing process. The crystals are interrogated via a single-side coil detector head, which transmits radio frequency (RF) pulses into the composite part. The strain-dependent QR response from the crystals is picked up by the same detector head. The results presented in this paper demonstrate that the QR method is very successful at distinguishing composites parts manufactured under optimal conditions from those that were manufactured with a misaligned die or at reduced temperatures. Both QR frequency and line widths were used as a distinguishing parameter.
Trypanosoma cruzi strains and autonomic nervous system pathology in experimental chagas disease (1996)

Lesions involving the sympathetic (para-vertebral ganglia) and para-sympathetic ganglia of intestines (Auerbach plexus) and heart (right atrial ganglia) were comparatively analyzed in mice infected with either of three different strain types of Trypanosoma cruzi, during acute and chronic infection, in an attempt to understand the influence of parasite strain in causing autonomic nervous system pathology. Ganglionar involvement with neuronal destruction appeared related to inflammation, which most of the times extended from neighboring adipose and cardiac, smooth and striated muscular tissues. Intraganglionic parasitism was exceptional. Inflammation involving peripheral nervous tissue exhibited a focal character and its variability in the several groups examined appeared unpredictable. Although lesions were generally more severe with the Y strain, comparative qualitative study did not allow the conclusion, under the present experimental conditions, that one strain was more pathogenic to the autonomic nervous system than others. No special tropism of the parasites from any strain toward autonomic ganglia was disclosed.
Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes (2005)

The mechanisms by which a cell uses and adapts its functional membrane organization are poorly understood and are the subject of ongoing investigation and discussion. Here, we study one proposed mechanism: the crosslinking of membrane components. In immune cell signaling (and other membrane-associated processes), a small change in the clustering of specific membrane proteins can lead to large-scale reorganizations that involve numerous other membrane components. We have investigated the large-scale physical effect of crosslinking a minor membrane component, the ganglioside GM1, in simple lipid models of the plasma membrane containing sphingomyelin, cholesterol, and phosphatidylcholine. We observe that crosslinking GM1 can cause uniform membranes to phase-separate into large, coexistent liquid ordered and liquid disordered membrane domains. We also find that this lipid separation causes a dramatic redistribution of a transmembrane peptide, consistent with a raft model of membrane organization. These experiments demonstrate a mechanism that could contribute to the effects of crosslinking observed in cellular processes: Domains induced by clustering a small number of proteins or lipids might rapidly reorganize many other membrane proteins.
Gene Expression Profiling of Human Liver Transplants Identifies an Early Transcriptional Signature Associated with Initial Poor Graft Function (2008)

Liver ischemia-reperfusion injury occurring in orthotopic liver transplantation (OLT) may be responsible for early graft failure. Molecular mechanisms underlying initial poor graft function (IPGF) have been poorly documented in human. The purpose of this study was to identify the major transcriptional alterations occurring in human livers during OLT. Twenty-one RNA extracts derived from liver transplant biopsies taken after graft reperfusion were compared with 7 RNA derived from normal control livers. Three hundred seventy-one genes were significantly modulated and classified in molecular pathways relevant to liver metabolism, inflammatory response, cell proliferation and liver protection. Grafts were then subdivided into two groups based on their peak levels of serum aspartate amino transferase within 72 h after OLT (group 1, non-IPGF: 14 patients; group 2, IPGF: 7 patients). The two corresponding data sets were compared using a supervised prediction method. A new set of genes able to correctly classify 71% of the patients was defined. These genes were functionally associated with oxidative stress, inflammation and inhibition of cell proliferation. This study provides a comprehensive picture of the transcriptional events associated with human OLT and IPGF. We anticipate that such alterations provide a framework for the elucidation of the molecular mechanisms leading to IPGF.
Pricing Financial Instruments: The Finite Difference Method (2000)

The Pricing Equations. Analysis of Finite Difference Methods. Special Issues. Coordinate Transformations. Numerical Examples. Index.
Reception of ELF signals at antipodal distances (1998)

Measurements of 82‐Hz radio signals from a Russian ELF transmitter located on the Kola Peninsula are described. The measurements were made at several locations around the world, including Dunedin, New Zealand, and Arrival Heights, Antarctica, which are close to the antipodal point for the transmitter. This is the first time man‐made ELF signals have been observed over such long distances, and their clear reception makes possible a comparison of the theoretically predicted and measured amplitudes near the antipode. The agreement is excellent.
Monetary policy in the 1990s: lessons and challenges (1989)

Monetary policy - Canada; Monetary policy
A novel DSF-like signal from <i>Burkholderia cenocepacia</i> interferes with <i>Candida albicans</i> morphological transition (2007)

In addition to producing lethal antibiotics, microorganisms may also use a new form of antagonistic mechanism in which signal molecules are exported to influence the gene expression and hence the ecological competence of their competitors. We report here the isolation and characterization of a novel signaling molecule, cis-2-dodecenoic acid (BDSF), from Burkholderia cenocepacia. BDSF is structurally similar to the diffusible signal factor (DSF) that is produced by the RpfF enzyme of Xanthomonas campestris. Deletion analysis demonstrated that Bcam0581, which encodes an RpfF homologue, was essential for BDSF production. The gene is highly conserved and widespread in the Burkholderia cepacia complex. Exogenous addition of BDSF restored the biofilm and extracellular polysaccharide production phenotypes of Xanthomonas campestris pv. campestris DSF-deficient mutants, highlighting its potential role in inter-species signaling. Further analyses showed that Candida albicans germ tube formation was strongly inhibited by either coculture with B. cenocepacia or by exogenous addition of physiological relevant levels of BDSF, whereas deletion of Bcam0581 abrogated the inhibitory ability of the bacterial pathogen. As B. cenocepacia and C. albicans are frequently encountered human pathogens, identification of the BDSF signal and its activity thus provides a new insight into the molecular grounds of their antagonistic interactions whose importance to microbial ecology and pathogenesis is now becoming evident.
Fourier transforms for vibration analysis: A review and case study (2011)

An important part of machine condition monitoring and prognostic health monitoring (MCM/PHM) using waveform sensors (such as vibration sensors) is data transformation, where the output from accelerometers is transformed into the time-frequency domain. Although Fourier analysis is a respected time-frequency transform in other application domains, many works in the field of MCM/PHM recommend against it and suggest more elaborate transforms such as wavelet-based approaches. These recommendations are not often justified by experimental data, however. In the present work, we present a discussion of the current state of research on Fourier transforms for MCM/PHM of vibration signals, as well as a case study demonstrating that for some experiments, the Fourier transform can produce very good results.
Design strategies for achieving high triplet energy electron transporting host materials for blue electrophosphorescence (2006)

High efficiency small molecule organic light emitting devices (OLEDs) based on light emission from an electrophosphorescent dopant dispersed in an organic host matrix are well known. Achieving blue phosphorescent OLEDs is particularly challenging because the host triplet energy should ideally be > 2.8 eV to prevent back-transfer of energy from the dopant to the host matrix resulting in loss of efficiency. A design strategy for developing new host materials with high triplet energies by using phosphine oxide (P=O) moieties as points of saturation in order to build sublimable, electron transporting host materials starting from small, wide bandgap molecular building blocks (i.e., biphenyl, phenyl, naphthalene, octafluorobiphenyl, and N-ethylcarbazole) is described. Electrophosphorescent OLEDs using the organic phosphine oxide compounds as host materials for the sky blue organometallic phosphor, iridium(III)bis(4,6-(di-fluorophenyl)-pyridinato-N,C<sup>2,</sup>) picolinate (FIrpic) give maximum external quantum efficiencies of ~ 8% and maximum luminance power efficiencies up to 25 lm/W.
Development of contact-type alcohol checking system (2010)

This paper describes a contact-type alcohol checker. The conventional checker is a breathalyzer type, which cannot always be used by the drivers themselves. Other applications pose the same problem. In this study, we evaluated the performance of a novel contact-type alcohol checker that can be easily embedded in a mobile phone or the steering wheel of a car. Alcohol is detected and measured from the driver's perspiration.
Bursts from high-energy nuclear-active particles at Mt. Chacaltaya (1975)

An experiment has been carried out to determine the energy spectrum of the high-energy nuclear-active particles without a shower accompaniment. Comparison of the observed spectra with the primary-proton spectrum shows that the inelastic cross section for collisions of protons with air nuclei increases with increasing energy over the range 3-9 TeV. 5 figures, 11 references. (auth)
Connective Tissue Growth Factor and Regulation of the Mesangial Cell Cycle (2002)

Connective tissue growth factor (CTGF) is now considered to be one of the important driver molecules for the pathogenesis of diabetic nephropathy (DN) and possibly many other fibrotic disorders. However, the molecular mechanisms by which CTGF functions remain to be established. In an attempt to define these mechanisms, this study was designed to investigate whether CTGF has any effect on the cell cycle of human mesangial cells (HMC), which are known to undergo hypertrophy in DN. This report provides the first evidence that CTGF is a hypertrophic factor for HMC. CTGF stimulates HMC to actively enter the G(1) phase from G(0), but they do not then progress further through the cell cycle. The molecular mechanisms underlying this G(1) phase arrest appear to be due to the induction of the cyclin-dependent kinase inhibitors (CDKI) p15(INK4), p21(Cip1), and p27(Kip1), which are known to bind and inactivate cyclinD/CDK4/6 and the cyclin E/CDK2 kinase complexes. This could account for the maintenance of pRb protein in a non- or very low-phosphorylated state, preventing cell cycle progression. Using CTGF antisense oligonucleotides, the results also indicate that the previously identified transforming growth factor-beta (TGF-beta)-induced hypertrophy in mesangial cells is CTGF-dependent. Mesangial cell hypertrophy is one of the earliest abnormalities of diabetic nephropathy; therefore, therapeutic strategies targeting CTGF may be beneficial in controlling DN.
Electrical characteristics of thin-film transistors using field-aided lateral crystallization (1999)

A polycrystalline silicon thin-film transistor (TFT) technology, field-aided lateral crystallization (FALC), has been explored. Polycrystalline silicon thin film, as an active layer, was prepared by applying an electric field to amorphous silicon film during Ni metal-induced lateral crystallization (MILC). Compared with the conventional metal-induced lateral crystallization thin-film transistors (MILC TFTs), these field-aided lateral crystallization thin-film transistors (FALC TFTs) show a low off-state leakage current of 1.79×10−11 A at Vg=−10 V and a high on/off current ratio of 8.82×105. Moreover, the threshold voltage is lower and field-effect mobility is higher than those of MILC TFTs. Therefore, the possibility of high-performance and low-temperature (&lt;500 °C) polycrystalline silicon TFTs was demonstrated by using FALC technology.
Automated Grocery Ordering Systems for Smart Home (2007)

In this paper, we propose an automated grocery ordering system for smart home. We have developed a stationary policy to minimize the total grocery shopping cost. A mathematical model is developed and an efficient algorithm is provided to obtain the optimal parameters for the proposed policy. Finally, we extend our results to more general cases where the storage system is capacitated and the ordering cost is given by a decreasing stepwise function of order quantity.
Nature of the semipolar XO bond. Comparative ab initio study of H3NO, H2NOH, H3PO, H2POH, H2P(O)F, H2SO, HSOH, HClO, ArO, and related molecules (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNature of the semipolar XO bond. Comparative ab initio study of H3NO, H2NOH, H3PO, H2POH, H2P(O)F, H2SO, HSOH, HClO, ArO, and related moleculesHolger Wallmeier and Werner KutzelniggCite this: J. Am. Chem. Soc. 1979, 101, 11, 2804–2814Publication Date (Print):May 1, 1979Publication History Published online1 May 2002Published inissue 1 May 1979https://doi.org/10.1021/ja00505a002Request reuse permissionsArticle Views231Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Crystallization of two cubic forms of soybean trypsin inhibitor E-I, a member of the Bowman-Birk inhibitor family. (1983)

The soybean trypsin inhibitor E-I, known to be relatively rich in methionine and cysteine, has been crystallized at room temperature in the presence of polyethylene glycol 4000, sodium chloride, and ammonium sulfate. A pronounced polymorphism in the crystals has been observed and two distinctly different cubic forms have been identified. Of the two, one form crystallizes in a unit cell of symmetry F432 with parameters a = b = c = 128.0 A, and diffracts at least to 2.6-A resolution. Each of the 96 asymmetric units contains one protein molecule, and has a solvent content of 60% by volume. The other form is of space group P4132 or P4332 with the unit-cell edge 87.1 A, and diffracts barely to 3-A spacings. The unit cell is composed of 24 asymmetric units, each of which probably also contains one molecule and has a solvent content of 69% by volume. The former cubic form appears to be more suitable for x-ray study than the latter in terms of stability and the extent of diffraction.
Tears of the tree: the story of rubber--a modern marvel (2006)

1. The Mesoamericans and the 'All American Ball Game' 2. Europe goes West 3. What's in a name? 4. The battles of the giants - Charles Goodyear 5. The battles of the giants - Thomas Hancock 6. Rubber goes East 7. The king and the Congo 8. Slaves to rubber 9. Competition! 10. The heavy mob 11. Chemicals and curatives 12. Padding or performance enhancer 13. The rot sets in 14. Death and destruction 15. Timeline
Teaching a Robot the Semantics of Assembly Tasks (2017)

We present a three-level cognitive system in a learning by demonstration context. The system allows for learning and transfer on the sensorimotor level as well as the planning level. The fundamentally different data structures associated with these two levels are connected by an efficient mid-level representation based on so-called “semantic event chains.” We describe details of the representations and quantify the effect of the associated learning procedures for each level under different amounts of noise. Moreover, we demonstrate the performance of the overall system by three demonstrations that have been performed at a project review. The described system has a technical readiness level (TRL) of 4, which in an ongoing follow-up project will be raised to TRL 6.
Method for High Precision Radar Distance Measurement and Synchronization of Wireless Units (2007)

In this paper we present a novel approach for high precision synchronization of wireless units. A concept similar to the standard FMCW (frequency-modulated continuous wave) radar principle is used to estimate the offset in time and in frequency between two radar units. It allows for a synchronization of both offsets significantly below 100 ps and 10 Hz, respectively. This highly accurate synchronization is used in a prototype system to measure the distance between wireless units similar to a secondary radar. The prototype operates within the 5.8 GHz ISM-Band and uses a bandwidth of 150 MHz. With the setup presented the distance between two radar units is measured with a standard deviation of less than 4 cm over a range of 250 m. The broadband measurement principle is robust towards multipath interference. It can be extended to other frequency bands and is well-suited for direct integration into communication channels.