gebhart/patrepeval huggingface dataset:
Pirfenidone for chronic progressive multiple sclerosis (2001)

Current treatment of secondary progressive multiple sclerosis is unsatisfactory in stabilizing or reversing the disabilities associated with the disease. Pirfenidone is a new non-peptide drug which has been shown in vitro and in vivo to decrease synthesis of Tumor Necrosis Factor-alpha (TNF-alpha) and block receptors for TNF-alpha. Since TNF-alpha seems to be a key cytokine in demyelination, a pilot study of oral pirfenidone was undertaken in an open-label baseline vs treatment protocol over a 2-year period in 20 patients. Fourteen (14120) patients (70%) remained in the study for 2 years. Three (3/20) patients dropped out early because of gastrointestinal adverse reactions, and another three patients dropped out for personal reasons after 1 year (not because of adverse reactions). The remaining patients did not manifest any other drug-related adverse reactions and complications. Improvement or stabilization occurred in most patients at about 3 months, and it was sustained at 6, 12 and 24 months as evaluated by both primary and secondary outcome measures. Magnetic resonance imaging foiled to reveal any new lesions. Thus, pirfenidone appears to offer protection against the usual slow progression of the disease. Most patients experienced a distinct decrease in their neurological disability. These findings indicate that an extensive multi-center double blind and placebo controlled trial is warranted.
Dynamic TTL-Based Search in Unstructured Peer-to-Peer Networks (2010)

Resource discovery is a challenging issue in unstructured peer-to-peer networks. Blind search approaches, including flooding and random walks, are the two typical algorithms used in such systems. Blind flooding is not scalable because of its high communication cost. On the other hand, the performance of random walks approaches largely depends on the random choice of walks. Some informed mechanisms use additional information, usually obtained from previous queries, for routing. Such approaches can reduce the traffic overhead but they limit the query coverage. Furthermore, they usually rely on complex protocols to maintain information at each peer. In this paper, we propose two schemes which can be used to improve the search performance in unstructured peer-to-peer networks. The first one is a simple caching mechanism based on resource descriptions. Peers that offer resources send periodic advertisement messages. These messages are stored into a cache and are used for routing requests. The second scheme is a dynamic Time-To-Live (TTL) enabling messages to break their horizon. Instead of decreasing the query TTL by 1 at each hop, it is decreased by a value v such as 0 <; v <; 1. Our aim is not only to redirect queries towards the right direction but also to stimulate them in order to reliably discover rare resources. We then propose a Dynamic Resource Discovery Protocol (DRDP) which uses the two previously described mechanisms. Through extensive simulations, we show that our approach achieves a high success rate while incurring a low search traffic.
Competition between pentoses and glucose during uptake and catabolism in recombinant Saccharomyces cerevisiae (2012)

Our results confirm that D-glucose impairs the simultaneous utilization of pentoses mainly due to inhibition of pentose uptake. Whereas intracellular D-glucose does not seem to have an inhibitory effect on pentose utilization, further catabolism of D-glucose can also impede pentose utilization. Nevertheless, the results suggest that co-fermentation of pentoses in the presence of D-glucose can significantly be improved by the overexpression of pentose transporters, especially if they are not inhibited by D-glucose.
Enhancing deep learning sentiment analysis with ensemble techniques in social applications (2017)

Deep learning techniques for Sentiment Analysis have become very popular. They provide automatic feature extraction and both richer representation capabilities and better performance than traditional feature based techniques (i.e., surface methods). Traditional surface approaches are based on complex manually extracted features, and this extraction process is a fundamental question in feature driven methods. These long-established approaches can yield strong baselines, and their predictive capabilities can be used in conjunction with the arising deep learning methods. In this paper we seek to improve the performance of deep learning techniques integrating them with traditional surface approaches based on manually extracted features. The contributions of this paper are sixfold. First, we develop a deep learning based sentiment classifier using a word embeddings model and a linear machine learning algorithm. This classifier serves as a baseline to compare to subsequent results. Second, we propose two ensemble techniques which aggregate our baseline classifier with other surface classifiers widely used in Sentiment Analysis. Third, we also propose two models for combining both surface and deep features to merge information from several sources. Fourth, we introduce a taxonomy for classifying the different models found in the literature, as well as the ones we propose. Fifth, we conduct several experiments to compare the performance of these models with the deep learning baseline. For this, we use seven public datasets that were extracted from the microblogging and movie reviews domain. Finally, as a result, a statistical study confirms that the performance of these proposed models surpasses that of our original baseline on F1-Score.
Antifungal and physical characteristics of modified denture base acrylic incorporated with silver nanoparticles (2012)

The modified denture base acrylic combined with silver nanoparticles displayed antifungal properties and acted like latent antifungal material itself with low-releasing Ag(+), however, the improvement of poor color stability was still required.
LargeBRCA1 gene deletions are found in 3% of German high-risk breast cancer families (2004)

We have tested for large BRCA1 gene rearrangements in German high-risk breast and ovarian cancer families previously screened negative for point mutations by dHPLC and sequencing. Using the novel MLPA method, two deletions of exons 1A, 1B and 2 and exon 17, respectively, were detected in four out of 75 families investigated in Southern Germany. An identical exon 17 deletion with the same breakpoints and a deletion of exons 1A, 1B and 2 were found by fluorescent multiplex PCR in two out of 30 families investigated in Northern Germany. Combining both populations, genomic rearrangements were found in 6% of the mutation-negative families and 3% of all high-risk families and account for 8% of all BRCA1 mutations. Our data indicate that the exon 17 deletion may be a founder mutation in the German population. The prevalence of BRCA1 gene deletions or duplications in our patients is similar to previous reports from Germany and France. Genomic quantification by MLPA is a useful method for molecular diagnostics in high-risk breast cancer families.
Lipoprotein lipase stored in adipocytes and muscle cells is a cryptic enzyme. (1990)

The status of lipoprotein lipase (LPL) has been examined in different cell types (adipose, skeletal muscle, and heart muscle cells) and different tissues (adipose, muscle, and cardiac tissues) from mouse, rat, and human. Cell and secreted activities were compared in cycloheximide-, heparin-treated cells present in culture. A gross underestimation of cell LPL activity was found; excess of LPL over substrate and/or apolipoprotein C-II was excluded as well as inhibition by cell component(s) or detergent molecules used to disrupt membrane structures in the cell lysates. Unmasking of LPL activity occurred upon dilution: the higher the concentration of LPL, the higher were the dilution factor and the concentration of heparin required to reach a plateau of activity. This maximal value was found to be identical to that determined in the secretion medium, indicating that the cell LPL activity can be determined in toto. The unmasking effect of dilution upon LPL activity was extended to adipose, muscle, and cardiac tissues from rat and to adipose tissues from mouse and human. In agreement with previous results (Vannier et al., 1989, J. Biol. 264: 13199-13205), our results are in favor of LPL as being cryptic within the cell. A model is proposed, in which potentially active LPL molecules are present as aggregates in various membrane compartments. It is concluded that the determination of the pool size of catalytically active cell LPL has to be estimated in vitro under the appropriate conditions described herein.
On-chip power supply for 110 V line input (1978)

A simple integrated power supply circuit in ESFI-SOS technology with only one external capacitor is presented. The circuit, which can directly be applied to 110 V AC line voltages, comprises a bridge rectifier, a `lambda'-type current switch, and a series regulator with overload protection. Because of the relatively small area consumption (6 mm/SUP 2/) the circuit to be supplied can easily be integrated on the same chip. Experimental results show a DC output power of about 100 mW (10 V/10 mA). Due to the lambda-type current switching high efficiencies of more than 30 percent are achieved. With some additional device modifications to increase breakdown voltage it should be possible to operate such circuits also with 220 V AC line voltages.
A comparison between free language and controlled language indexing and searching (1990)

This project compares natural language indexing and searching with controlled language searching in a computer-based environment. A small database containing titles, descriptors from the ERIC thesaurus and subject headings from Sears List of Subject
Biological subtypes of breast cancer: current concepts and implications for recurrence patterns. (2013)

Breast cancer is comprised of a number of complex and heterogeneous subtypes with differing clinical behavior and outcomes. In recent years, significant advances have been made in discerning the molecular drivers of this disease, and characterizing distinct subtypes of breast cancer based on gene expression profiles. These advances have begun to translate into greater individualization of treatment for patients. Although these advances have shaped our understanding of the underlying biology of breast cancer, most clinical decisions are currently based on tumor expression of the estrogen receptor (ER), progesterone receptor (PR) and the human epidermal growth factor receptor 2 (HER2). These biomarkers have prognostic and predictive significance in breast cancer and have important implications for tumor growth and metastatic patterns. In this review, we focus on the three broad phenotypes of breast cancer used in clinical practice; ER/PR positive, HER2 positive and triple negative breast cancer (TNBC), which is characterized by lack of expression of ER, PR and HER2. We discuss the influence of these tumor-related factors as well as histological subtype, on the potential for breast cancer recurrence and patterns of disease spread.
Measurements and Simulations of Electrochemical Impedance Spectroscopy of a Three-Electrode Coin Cell Design for Li-Ion Cell Testing (2014)

International audience
Autonomous tracking of vehicle rear lights and detection of brakes and turn signals (2012)

Automatic detection of vehicle alert signals is extremely critical in autonomous vehicle applications and collision avoidance systems, as these detection systems can help in the prevention of deadly and costly accidents. In this paper, we present a novel and lightweight algorithm that uses a Kalman filter and a codebook to achieve a high level of robustness. The algorithm is able to detect braking and turning signals of the vehicle in front both during the daytime and at night (daytime detection being a major advantage over current research), as well as correctly track a vehicle despite changing lanes or encountering periods of no or low-visibility of the vehicle in front. We demonstrate that the proposed algorithm is able to detect the signals accurately and reliably under different lighting conditions.
Mostly passive information delivery in a car (2013)

In this study we present and analyze a mostly passive infotainment approach to presenting information in a car. The passive style is similar to radio listening but content is generated on the fly and it is based on a mixture of personal information (calendar, emails) and public data (news, POI, jokes). The spoken part of the audio is machine synthesized. We explore two modes of operation. The first one is passive only. The second one is more interactive and speech commands are used to personalize the information mix and to request particular information items. Usability and distraction tests were conducted with both systems implemented using the Wizard of Oz technique. Both systems were assessed using multiple objective and subjective metrics and the results indicate that driver distraction was low for both systems. The users differed in the amount of interaction they preferred. Some users preferred more command-driven styles while others were happy with passive presentation. Most of the users were satisfied with the quality of synthesized speech and found it sufficient for the given purpose. In addition, feedback was collected from the subjects on what kind of information they liked listening to and how they would have preferred to ask for specific types of information.
Carrier Lifetime Reduction by Argon Implantation into Silicon (1984)

The reduction of carrier generation lifetime caused by argon implantation into silicon has been studied as a function of argon dose and annealing treatments. The capacitance transient technique was used to deduce that: (i) carrier generation lifetime in the depletion region decreases by four orders of magnitude with doses up to 1014 cm−2, and varies inversely with dose; (ii) the separable contribution to capacitance relaxation due to surface generation and diffusion varies as the square of the dose. The region of low lifetime appears to remain localized within 1 μm from the surface even after annealing for 1h at 1200°C. Partial recovery of generation lifetime occurs after annealing for 1h at 1100° or 1200°C. Complete recovery was observed only after several hours at 1200°C, and slow cooling (2°C min−1). The resistance to high temperature treatment implies that regions of low lifetime can be incorporated with three‐dimensional control into device structures.
Malat1 is not an essential component of nuclear speckles in mice (2012)

Malat1 is an abundant long, noncoding RNA that localizes to nuclear bodies known as nuclear speckles, which contain a distinct set of pre-mRNA processing factors. Previous studies in cell culture have demonstrated that Malat1 interacts with pre-mRNA splicing factors, including the serine- and arginine-rich (SR) family of proteins, and regulates a variety of biological processes, including cancer cell migration, synapse formation, cell cycle progression, and responses to serum stimulation. To address the physiological function of Malat1 in a living organism, we generated Malat1-knockout (KO) mice using homologous recombination. Unexpectedly, the Malat1-KO mice were viable and fertile, showing no apparent phenotypes. Nuclear speckle markers were also correctly localized in cells that lacked Malat1. However, the cellular levels of another long, noncoding RNA--Neat1--which is an architectural component of nuclear bodies known as paraspeckles, were down-regulated in a particular set of tissues and cells lacking Malat1. We propose that Malat1 is not essential in living mice maintained under normal laboratory conditions and that its function becomes apparent only in specific cell types and under particular conditions.
SQL Injection — Database Attack Revolution and Prevention (2010)

Abstract. SQL injection came with a bang and caused revolution in database attacking. In recent years, with the explosion in web-based commerce and information systems, databases have been drawing ever closer to the network and it is critical part of network security. This paper is incorporated with our research and firsthand experience in hacking the database by SQL injection. Database is the Storage Brain of a website. A hacked database is the source for Passwords and juicy information like credit card number, bank account number and every important thing that are forbidden. Importance should be given for preventing database exploitation by SQL injection. The aim of this paper is to create awareness among web developers or database administrators about the urgent need for database security. Our ultimate objective is to totally eradicate the whole concept of SQL injection and to avoid this technique becoming a plaything in hands of exploiters. 1.
Eradication of Pulmonary Aspergillosis in an Adolescent Patient Undergoing Three Allogeneic Stem Cell Transplantations for Acute Lymphoblastic Leukemia (2012)

Systemic fungal infections are a major cause of infection-related mortality in patients with hematologic malignancies. This report addresses the case of an adolescent patient with acute lymphoblastic leukemia who underwent three allogeneic hematopoietic stem cell transplantations and developed pulmonary aspergillosis. Combination therapy with liposomal amphotericin B (L-AmB, 3 mg/kg bw/day) and caspofungin (CAS, 50 mg/day) during the first allogeneic hematopoietic stem cell transplantation (HSCT) improved the pulmonary situation. After shifting the antifungal combination therapy to oral voriconazole (2 × 200 mg/day) and CAS, a new pulmonal lesion occurred alongside the improvements in the existing pulmonary aspergillosis. An antifungal combination during a second HSCT with L-AmB (3 mg/kg bw/day) and CAS showed an improvement in the pulmonary aspergillosis. A combination therapy with CAS and L-AmB (1 mg/kg bw/day) during the third HSCT led once again to progress the pulmonary aspergillosis, after increasing the L-AMB to 3 mg/kg bw/day for recovery. The presented case provides an example of how, despite severe immunosuppression, a combination of antifungal drugs administered intravenously at therapeutic dosages may be more efficient than either intravenous monotherapy or combinations of intravenous and oral antifungals in selecting pediatric and adolescent patients with proven fungal infections.
Receding horizon control of nonlinear systems (1990)

The receding horizon control strategy provides a relatively simple method for determining feedback control for linear or nonlinear systems. The method is especially useful for the control of slow nonlinear systems, such as chemical batch processes, where it is possible to solve, sequentially, open-loop fixed-horizon, optimal control problems online. The method has been shown to yield a stable closed-loop system when applied to time-invariant or time-varying linear systems. It is shown that the method also yields a stable closed-loop system when applied to nonlinear systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Matrix Metalloproteinase Homologues from Arabidopsis thaliana (1999)

Five genes potentially encoding novel matrix metalloproteinases (MMPs) have been identified on the Arabidopsis thaliana data base. The predicted proteins have a similar domain structure to mammalian MMP-7, with a propeptide and catalytic domain but no C-terminal hemopexin-like domain. Four of the A. thaliana MMPs (At-MMPs) have a predicted C-terminal transmembrane domain. The At-MMPs are differentially expressed in flower, leaf, root, and stem tissues from 14-day-old plants. The cDNA for one of the At-MMPs (At1-MMP) was cloned and expressed in Escherichia coli. Following refolding and purification, the proenzyme At1-MMP was shown to undergo autolytic activation in the presence of an organomercurial with a concomitant decrease in M(r). In contrast to this, trypsin-treatment led to the formation of an inactive product. The activated At1-MMP digested myelin basic protein, but was unable to digest gelatin or casein. Three peptide substrates for MMPs were also cleaved by At1-MMP. The enzyme activity of At1-MMP was inhibited by human tissue inhibitors of metalloproteinases 1 and 2 and the hydroxamate inhibitor BB-94.
Optimizing performance of fuzzy decision support system with multiple parameter dependency for cloud provider evaluation (2017)

Manuscript removed
Broadbandloop: a full-service access network for residential and small business users (1997)

There is a worldwide effort to define a full-service access network. The Broadbandloop project was formed by a European consortium funded by the European Union with the objective of defining a strategy for evolution from a narrowband voice and data network to a broadband network. The project is defining a system concept based on new innovative PON technology, which enables fiber to cost effectively penetrate close to the customer, and VDSL technology for transmission over twisted copper pairs. The system concept is validated in field trials in Denmark, Portugal, and Poland. The article describes the different requirements for a full-service access network, the system concept, and technologies developed. Results from modeling of broadband traffic and the corresponding bandwidth are given. The cost effectiveness of using new optical fiber vs. reusing existing telephone copper plant has been evaluated, and results from these studies are presented.
The Dynamic Host Configuration Protocol for IPv6 (DHCPv6) Client Fully Qualified Domain Name (FQDN) Option (2006)

This document specifies a new Dynamic Host Configuration Protocol for
IPv6 (DHCPv6) option that can be used to exchange information about a
DHCPv6 client's Fully Qualified Domain Name (FQDN) and about
responsibility for updating DNS resource records (RRs) related to the
client's address assignments. [STANDARDS-TRACK]
The Phylloplane as a Source of <i>Bacillus thuringiensis</i> Variants (1991)

Novel variants of Bacillus thuringiensis were isolated from the phylloplane of deciduous and conifer trees as well as of other plants. These isolates displayed a range of toxicity towards Trichoplusia ni. Immunoblot and toxin protein analysis indicate that these strains included representatives of the three principal B. thuringiensis pathotypes active against larvae of the orders Lepidoptera, Diptera, and Coleoptera. We propose that B. thuringiensis be considered part of the common leaf microflora of many plants.