124 POST-STIMULATION INHIBITORY EFFECT ON REFLEX BLADDER ACTIVITY INDUCED BY ACTIVATION OF SOMATIC AFFERENT NERVES IN THE CAT FOOT (2012)

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Basic Research II1 Apr 2012124 POST-STIMULATION INHIBITORY EFFECT ON REFLEX BLADDER ACTIVITY INDUCED BY ACTIVATION OF SOMATIC AFFERENT NERVES IN THE CAT FOOT Guoqing Chen, Jeffrey A. Larson, P. Dafe Ogagan, Bing Shen, Jicheng Wang, James R. Roppolo, William C. de Groat, and Changfeng Tai Guoqing ChenGuoqing Chen Beijing, China, People's Republic of More articles by this author , Jeffrey A. LarsonJeffrey A. Larson Pittsburgh, PA More articles by this author , P. Dafe OgaganP. Dafe Ogagan Pittsburgh, PA More articles by this author , Bing ShenBing Shen Pittsburgh, PA More articles by this author , Jicheng WangJicheng Wang Pittsburgh, PA More articles by this author , James R. RoppoloJames R. Roppolo Pittsburgh, PA More articles by this author , William C. de GroatWilliam C. de Groat Pittsburgh, PA More articles by this author , and Changfeng TaiChangfeng Tai Pittsburgh, PA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.172AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Overactive bladder (OAB) symptoms are often difficult to manage with medications. It is known that electrical stimulation of somatic afferent pathways in the pudendal and posterior tibial nerves, or sacral roots can inhibit bladder activity in both humans and animals, and is clinically effective in treating OAB symptoms. The purpose of this study is to determine if transcutaneous electrical stimulation of somatic afferent nerves in the foot of cats can induce a post-stimulation increase in bladder capacity. METHODS A total of 24 cats (19 females, 5 males) were used in the study. In 12 α-chloralose anesthetized cats, electrical stimulation (5 Hz) was applied to the skin of the hind foot for two periods of 30 minutes via dual pad electrodes attached on the plantar and dorsal surfaces (combination 1 and 2), or at two sites on the plantar surface (combination 1 and 3). In 12 α-chloralose anesthetized control cats, the isovolumetric contractions were allowed to continue during two periods of 30 minutes without electrical stimulation. In both groups, the post-stimulation effect was examined by performing repeated cystometrograms (CMG) following each 30 minute period of stimulation or isovolumetric contractions. After inducing the post-stimulation effect, foot stimulation was then applied during CMGs via electrode combinations 1 and 2, or 1 and 3. RESULTS Stimulation inhibited isovolumetric rhythmic bladder contractions. Bladder capacity was not increased after the first 30 minute foot stimulation via electrodes 1 and 2, but it was significantly increased a mean ± SE of 47.5% ± 2.9% after the second 30 minute stimulation via electrode combination 1 and 3. After inducing the post stimulation effect, the foot stimulation applied during CMGs via electrodes 1 and 2, or 1 and 3 elicited a further increase in bladder capacity of mean ± SE of 30.0% ± 6.7% and 28.5% ± 7.0% respectively. CONCLUSIONS The study results show that the transcutaneous plantar electrical stimulation of somatic afferent nerves in the foot of anesthetized cats can induce a post stimulation increase in bladder capacity, suggesting that an intermittent stimulation pattern rather than continuous stimulation might be effective as clinical application to treat overactive bladder symptoms. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e51 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Guoqing Chen Beijing, China, People's Republic of More articles by this author Jeffrey A. Larson Pittsburgh, PA More articles by this author P. Dafe Ogagan Pittsburgh, PA More articles by this author Bing Shen Pittsburgh, PA More articles by this author Jicheng Wang Pittsburgh, PA More articles by this author James R. Roppolo Pittsburgh, PA More articles by this author William C. de Groat Pittsburgh, PA More articles by this author Changfeng Tai Pittsburgh, PA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...