gebhart/patrepeval huggingface dataset:
Scanning electron probe microanalysis. (1965)

Recrystallized dental alloy
Plasma doping and reduced crystalline damage for conformally doped fin field effect transistors (2013)

Low frequency noise and hot carrier reliability analysis of the plasma doping scheme are investigated for advanced fin field effect transistor (FinFET) conformal doping. Plasma doping improves device performances and hot carrier reliability for both fin resistors and FinFETs due to the absence of crystalline damage for narrow fins. One decade lower noise level and Coulomb scattering coefficient related to the crystalline damage suppression are observed for the plasma doping compared to the standard ion-implantation.
N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein. (1993)

P-glycoproteins are heavily glycosylated plasma membrane proteins, which confer multidrug resistance by pumping a range of different drugs from the cell. To investigate the significance of the conserved N-glycosylation sites present in the putative first extracellular loop of P-glycoproteins, we mutated one, two, or all three of these sites present in the human MDR1 P-glycoprotein. We also deleted a stretch of 20 amino acids, containing two of the three N-glycosylation sites. The effects of these mutations were studied by transfection into drug-sensitive cells. In vincristine-resistant transfected clones selected for similar steady state levels of membrane-bound P-glycoprotein, the absence of N-glycosylation did not alter the level or pattern of (cross-)resistance. However, the absence of N-glycosylation sites drastically reduced the efficiency with which drug-resistant clones could be generated. These findings suggest that N-glycosylation contributes to proper routing or stability of P-glycoprotein but not to drug transport per se. The deletion mutants demonstrated a clearly decreased and altered drug resistance pattern, even with a high level of P-glycoprotein in the plasma membrane. This, and possibly the observed lack of glycosylation of the remaining intact glycosylation sequence, suggests a constrained P-glycoprotein structure. Our findings support the current model for P-glycoprotein structure.
EFFECT OF ANTIBIOTICS AND INHIBITORS ON M PROTEIN SYNTHESIS (1963)

Brock, Thomas D. (Western Reserve University, Cleveland, Ohio). Effect of antibiotics and inhibitors on M protein synthesis. J. Bacteriol. 85:527-531. 1963.-This work extends the observations of Fox and Krampitz on M protein synthesis in nongrowing cells of streptococci. A survey of a large number of antibiotics and other potential inhibitors was made. Some substances bring about inhibition of fermentation and inhibit M protein synthesis because they deprive the cell of the energy needed for this process. A second group of substances inhibit growth at concentrations tenfold or more lower than they inhibit M protein synthesis. These are the antibiotics which inhibit synthesis of cell wall or other structures in growing cells, but do not affect protein synthesis. A third group of substances inhibit growth and M protein synthesis at the same concentration. These substances probably inhibit growth because they inhibit general protein synthesis, and are therefore specific inhibitors of protein synthesis. In this class are chloramphenicol, erythromycin, and the tetracyclines. Several other antibiotics of previously unknown mode of action are in this class. A fourth group of substances had no effect on M protein synthesis. No substances were found which inhibited M protein synthesis at a lower concentration than that which inhibited growth. M protein synthesis in nongrowing cells may be a useful model system for obtaining a detailed understanding of protein synthesis.
Über Peptidsynthesen, XV!!!. Neue <i>O</i>‐tert.‐Butyl‐hydroxyaminosäure‐Derivate und ihre Verwendung zur Synthese von Glukagon‐Teilsequenzen (1963)

Abstract Es werden Carbobenzoxy‐ O ‐tert.‐butyl‐hydroxyaminosäuren (Serin, Threonin, Tyrosin), Carbobenzoxy‐ und tert.‐Butyloxycarbonyl‐ O ‐tert.‐butyl‐hydroxy‐aminosäurehydrazide sowie O ‐tert.‐Butyl‐hydroxyaminosäureester beschrieben. Serin und Tyrosin lassen sich mit Isobutylen/konz. Schwefelsäure direkt in die tert.‐Butyläther‐tert.‐butylester überführen. Die N ‐terminale Glukagon‐Sequenz 1–6 wird auf zwei Wegen als tert.‐Butyloxycarbonyl‐ L ‐histidyl‐ O ‐tert.‐butyl‐ L ‐seryl‐ L ‐glutaminyl‐glycyl‐ L ‐threonyl‐ L ‐phenylalaninhydrazid synthetisiert.
Highly discriminating heptaplex short tandem repeat PCR system for forensic identification. (1995)

We describe a highly discriminating multiplex short tandem repeat PCR human identification system that gives a matching probability for Caucasians of European ancestry of 2.94 x 10(-8) or 5.66 x 10(-10) when used in combination with a previously described system. The system produces discrimination equal to or greater than four single locus probes (restriction fragment length polymorphism [RFLP] typing of variable nucleotide tandem repeat [VNTR] loci). The test is robust and reproducible and works with 1-10 ng of template DNA, using fluorescent detection of PCR products from either 4 or 6 short tandem repeat loci and the X-Y homologous gene amelogenin, giving simultaneous sex diagnosis.
Relative stability of normal vs. inverse spinel for 3d transition metal oxides as lithium intercalation cathodes (2013)

Spinel oxides represent an important class of cathode materials for Li-ion batteries. Two major variants of the spinel crystal structure are normal and inverse. The relative stability of normal and inverse ordering at different stages of lithiation has important consequences in lithium diffusivity, voltage, capacity retention and battery life. In this paper, we investigate the relative structural stability of normal and inverse structures of the 3d transition metal oxide spinels with first-principles DFT calculations. We have considered ternary spinel oxides LixM2O4 with M = Ti, V, Cr, Mn, Fe, Co and Ni in both lithiated (x = 1) and delithiated (x = 0) conditions. We find that for all lithiated spinels, the normal structure is preferred regardless of the metal. We observe that the normal structure for all these oxides has a lower size mismatch between octahedral cations compared to the inverse structure. With delithiation, many of the oxides undergo a change in stability with vanadium in particular, showing a tendency to occupy tetrahedral sites. We find that in the delithiated oxide, only vanadium ions can access a +5 oxidation state which prefers tetrahedral coordination. We have also calculated the average voltage of lithiation for these spinels. The calculated voltages agree well with the previously measured and calculated values, wherever available. For the yet to be characterized spinels, our calculation provides voltage values which can motivate further experimental attention. Lastly, we observe that all the normal spinel oxides of the 3d transition metal series have a driving force for a transformation to the non-spinel structure upon delithiation.
Inspection of Samples using a fast Millimetre Wave Scanner (2011)

Art. 012033
165. The alkylation of mercaptobenzothiazole (1958)

K. J. Morgan, J. Chem. Soc., 1958, 854 DOI: 10.1039/JR9580000854
Radioelectroencephalography (Tele-Stereo-EEG) in the Rat as a Pharmacological Model to Differentiate the Central Action of Flupirtine from That of Opiates, Diazepam and Phenobarbital (1986)

Chronic implantation of 4 bipolar concentric electrodes into frontal cortex, thalamus, striatum and reticular formation allowed repeated recordings of field potentials from freely moving rats. After radiotransmission the signals were quantitatively evaluated by spectral power analysis. The power in particular frequency bands changed in the presence of drugs in a characteristic manner and allowed us to describe the central action of analgesics in comparison with diazepam and phenobarbital. Analysis of the data showed that the action of diazepam was mainly confined to alpha 1 and beta 2 frequencies whereas tramadol acted predominantly on the theta and alpha range. Buprenorphine and morphine most consistently influenced the alpha 2 frequencies. Whereas buprenorphine and tramadol (2 opiate drugs) showed a striking similarity to the action of morphine in corresponding brain areas the minor tranquilizer diazepam and the anticonvulsive phenobarbital could clearly be separated from them. Flupirtine, a new analgesic not suspected of an opiate-like action profile, did not resemble any of them and thus could be confirmed to have a different mode of action.
Quantity of Remaining Double Bonds of Diacetyl-containing Resins (1994)

The present study determined the effect of diacetyl addition on the quantity of remaining double bonds of dental resins. Diacetyl was added to monomer mixtures, which were then made light-curing. The monomer mixtures were varied with respect to monomer composition and content of diacetyl. The quantity of remaining double bonds was determined by means of transmission infrared spectra of the resins recorded before and after wet or dry storage for one wk. Addition of diacetyl resulted in a decrease in the quantity of remaining double bonds by as much as 78% as compared with the mixtures without diacetyl. Negative correlations of statistical significance were found between content of diacetyl and quantity of remaining double bonds in BISGMA: TEGDMA-based as well as in UEDMA: HEMA-based resins for both modes of storage. Significant negative correlations were found between quantity of remaining double bonds and the previously determined mechanical properties.
Using Write Protected Data Structures To Improve Software Fault Tolerance in Highly Available Database Management Systems (1991)

This paper describes a database management system (DBMS) modified to use hardware write protection to guard critical DBMS data structures against software errors. Guarding (write-protecting) DBMS data improves software reliability by providing quick detection of corrupted pointers and array bounds overruns. Guarding will be especially helpful in an extensible DBMS since it limits the power of extension code to corrupt unrelated parts of the system. Read-write data structures can be guarded as long as correct software is able to temporarily unprotect the data structures during updates. The paper discusses the effects of three different update models on performance, software complexity, and error protection. Measurements of a DBMS which uses guarding to protect its buffer pool show two to eleven percent performance degradation in a debit/credit benchmark. 1. Introduction Today, software errors are the largest cause of failure in fault tolerant transaction processing systems [Gray90]. B...
VISIR, a simulation software for domotics installations to improve laboratory training (2002)

This paper focuses on the programming and configuration stages of the domotics systems (automation technology applied to the technical management of houses and buildings), which are carried out in the laboratory prior to its definitive installation in houses and buildings. Different hardware and software tools for testing and debugging domotics systems are described. Because of their limitations (cost, closeness to the real system, flexibility, maintenance, etc.) we have developed a new software simulation tool called VISIR, which is comprised of three components: Editor, Drawing and Simulation. This paper describes VISIR features and operation modes using an example. All of this allows important advantages to be found in using this software for domotics laboratory training.
Analysis of the code allocation mechanism in the WCDMA (2003)

The technique of spread spectrum is already normalized to be the unique technique in future wireless systems. The system is based on the sharing of the same bandwidth simultaneously by modulating the information of every user with a specific code that distinguish him in the cell; the chip rate of which is much higher than the data bit rate. This type of access technique will generate an important interference called multiple access interference (MAI) that limits the capacity of the system. Therefore, the system capacity will depend on the types of spreading codes and how these spreading codes are allocated. We analyze the affect of spreading codes on the system capacity by studying the impact of the non-orthogonal property between these codes.
A New Method of Measuring Nuclear Magnetic Moment (1938)

To apply these ideas a beam of molecules in a 'Z state (no electronic moment) is spread by an inhomogeneous magnetic field and refocused onto a detector by a subse- quent field, somewhat as in the experiment of Kellogg, Rabi and Zacharias.' As in that experiment the re-orienting
Acetyl-DL-leucine improves gait variability in patients with cerebellar ataxia—a case series (2016)

Acetyl-DL-leucine is a modified amino acid that was observed to improve ataxic symptoms in patients with sporadic and hereditary forms of ataxia. Here, we investigated the effect of the treatment with Acetyl-DL-leucine on the walking stability of patients with cerebellar ataxia (10x SAOA, 2x MSA-C, 2x ADA, 1x CACNA-1A mutation, 2x SCA 2, 1x SCA 1). Treatment with Acetyl-DL-leucine (500 mg; 3-3-4) significantly improved the coefficient of variation of stride time in 14 out of 18 patients. Moreover, subjective ambulatory scores (FES-I and ABC) and the SARA scores were also improved under treatment. Further prospective studies are necessary to support these class III observational findings.
Cruz Piñol, M. (2017), Lingüística de corpus y enseñanza de español como 2/L, Madrid, Arco Libros (2017)

Review: Cruz Piñol, M. (2017), Lingüística de corpus y enseñanza de español como 2/L, Madrid, Arco Libros.
Expression of capsid proteins of serotype O foot-and-mouth disease virus in insect cells (2013)

To construct the recombinant baculovirus expressing capsid proteins of serotype O foot-and-mouth disease virus(FMDV),a fusion gene of P1-2A and 3C of FMDV O/YS/CHA/05 strain was expressed from the constructed recombinant baculovirus rBV-P12A3C in Sf9 cells detected by indirect immunefluorescence assay.Western blot analyses showed that the expressed capsid protein was correctly cleavage by 3C proteinase.In addition,expression kinetics analysis showed that the expressed FMDV capsid proteins possessed good reactogenicity and the maximal expression of the capsid proteins in Sf9 cells occurred at the 4th day post infection with the recombinant baculovirus.The construction of the recombinant baculovirus would help to study the assembly of FMDV empty capsids in vitro and develop the serotype O FMDV empty capsid vaccine.
The relationship between potency of oxidative stress and severity of depression (2004)

Background: Oxidative stress is one of the suggested mechanisms in major depression. Objective: To determine the oxidative and antioxidative status of plasma of patients with major depression and to investigate whether there is a relationship between the potency of oxidative stress and the severity of depression. Methods: To determine the antioxidative status of plasma, total and individual antioxidant levels which are total antioxidant potential (TAOP), total protein, albumin, uric acid, vitamin C and total bilirubin were measured. To determine the oxidative status, total peroxide level of plasma was measured in patients with drug-free depressive patients and compared with those of controls. Per cent ratio of total peroxide to TAOP was evaluated as oxidative stress index (OSI). Results: Plasma TAOP and individual antioxidant levels were found to be lower in patients with depression than those of controls. On the contrary, the patients had high total plasma peroxide levels. OSI values of the patients were significantly higher than those of controls ( P = 0.002), and a significant positive correlation between Hamilton Depression Rating Scale (HDRS) and OSI values was found ( r = 0.54, P = 0.01). Conclusions: The patients with major depression are exposed to oxidative stress, and OSI may be useful to reflect the severity of the disease.
Triangular lattices for mutual coupling reduction in patch antenna arrays (2011)

One of the issues in antenna arrays is the mutual coupling that occurs when two radiating elements are placed together. Mutual coupling can significantly degrade the performance of an antenna array. In this paper, we propose a triangular lattice configuration as a technique to reduce the mutual coupling in patch antenna arrays. A 4-element circular patch array with a triangular lattice is simulated and compared against a 4-element circular patch array with a square lattice in terms of their mutual coupling and radiation pattern. Comparisons are also made with other mutual coupling reduction techniques for closely packed antennas such as ground structure with slits, ground structures with removed substrates and ground structures with metal wall. The triangular lattice concept is then extended to the 9-element circular patch array. The 4-elements circular patch array with the triangular lattice and square lattice operating at 2.6GHz are then fabricated on FR4 printed circuit board.
2. Gibberellic acid. Part XIX. The degradation of gibberellic acid in sulphuric acid (1963)

R. N. Speake, J. Chem. Soc., 1963, 7 DOI: 10.1039/JR9630000007
Managing bounded code caches in dynamic binary optimization systems (2006)

Dynamic binary optimizers store altered copies of original program instructions in software-managed code caches in order to maximize reuse of transformed code. Code caches store code blocks that may vary in size, reference other code blocks, and carry a high replacement overhead. These unique constraints reduce the effectiveness of conventional cache management policies. Our work directly addresses these unique constraints and presents several contributions to the code-cache management problem. First, we show that evicting more than the minimum number of code blocks from the code cache results in less run-time overhead than the existing alternatives. Such granular evictions reduce overall execution time, as the fixed costs of invoking the eviction mechanism are amortized across multiple cache insertions. Second, a study of the ideal lifetimes of dynamically generated code blocks illustrates the benefit of a replacement algorithm based on a generational heuristic. We describe and evaluate a generational approach to code cache management that makes it easy to identify long-lived code blocks and simultaneously avoid any fragmentation because of the eviction of short-lived blocks. Finally, we present results from an implementation of our generational approach in the DynamoRIO framework and illustrate that, as dynamic optimization systems become more prevalent, effective code cache-management policies will be essential for reliable, scalable performance of modern applications.
Adrenocortical Carcinoma Evolving after Diagnosis of Preclinical Cushing’s Syndrome in an Adrenal Incidentaloma (1998)

A 43-year-old female patient underwent abdominal ultrasonography and CT scan because of uncharacteristic abdominal pain. A 3-cm homogeneous adrenal tumor was diagnosed. The endocrine tests revealed an adrenal preclinical Cushing's syndrome (PCS). Due to the latent hormone excess we decided to operate on the adrenal tumor. Since the tumor was small, laparoscopic adrenalectomy was performed. Histological evaluation showed an adrenocortical tumor of undetermined nature. Four months later the patient presented with a metastasizing cortisol- and androgen-producing adrenocortical carcinoma (ACC). After pretreatment with ketoconazole to suppress the biosynthesis of adrenal steroids under substitution with hydrocortisone, we reduced the tumor load by surgery. Postoperatively we continued ketoconazole and started o, p'-dichlorodiphenyldichloroethane as well as chemotherapy with doxorubicin and suramin. However, the patient died from ACC 7 months after adrenalectomy. It is known from several reports that PCS may persist clinically silently or may progress to full-blown Cushing's syndrome. This is the first time a malignant course of PCS is described. Independent of the initial therapeutic strategy of PCS, i. e. surgery or regular follow-up visits, we must be aware that also relatively small adrenal tumors can harbor malignancy.
Method for Analysis of Tannic Acid and Its Metabolites in Biological Samples:  Application to Tannic Acid Metabolism in the Rat (2002)

A new analytical method for measuring tannic acid (TA) using tannase was developed and applied to the investigation of TA metabolism in the rat following oral administration at a dose of 1.0 g/kg. The proposed method for TA determination was based on the enzymatic hydrolysis of TA to gallic acid (GA) and subsequent determination by HPLC. TA metabolites were determined by HPLC. 4-O-Methylgallic acid (4-OMGA), pyrogallol (PY), and resorcinol (RE) were detected in serum. TA was excreted into urine as GA (0.01%), 4-OMGA (0.10%), PY (0.24%), and RE (2.06%) and into feces as TA (62.74%), GA (0.19%), PY (0.02%), and RE (0.76%) within 54 h after oral administration. It was suggested that >60% of TA remained unchanged but that some was hydrolyzed to GA by tannase in the intestine and further metabolized to 4-OMGA, PY, and RE.
„Herr Doktor, mir sind meine Otolithen entsprungen“ (2012)

So begrüßte mich kürzlich aufgeregt eine ältere Dame. Die Otolithen ließen sich schnell wieder „einfangen“, denn ich konnte ihr ein Blatt mit Übungsprogramm aus der zkm 6/2011 aushändigen, in der wir uns mit Schwindel beschäftigt hatten.
Recent Developments in ARC Suppression for Picture Tubes (1979)

A review of past developments in picture tube arc suppression systems and a description of an extremely effective new system are presented. Known commercial devices employ an internal resistive coating between the gun anode and picture tube ultor (anode button). A significant difficulty encountered with such devices is due to highly conductive barium getter material which is evaporated inside the picture tube during processing. It tends to short out the internal resistive coating. Conventional antenna getters employ a spring support which also may cause bypassing of the arc suppression coating. Previously described arc limiting systems circumvent this problem by mounting the getter from the anode button or color picture tube mask using special directional shields to minimize the amount of getter flash on the arc suppression resistor coating.
A Modular Approach to Functionalized and Expanded Crown Ether Based Macrocycles Using Click Chemistry (2009)

Tailored handcuffs: α-Azide-ω-alkyne oligomers are obtained in high yields from copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC), iterative chain growth, and protection–deprotection strategies. Intramolecular CuAAC under pseudo-high-dilution conditions then yields macrocycles with n=1–8 triazole units in the cyclic backbone (picture shows n=2; C gray, O red, N blue, H white).