gebhart/patrepeval huggingface dataset:
Non-Thermal Annealing Fabrication of Efficient Planar Perovskite Solar Cells with Inclusion of NH<sub>4</sub>Cl (2015)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNon-Thermal Annealing Fabrication of Efficient Planar Perovskite Solar Cells with Inclusion of NH4ClYani Chen†, Yixin Zhao‡, and Ziqi Liang*†View Author Information† Department of Material Science, Fudan University, Shanghai 200433, China‡ College of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China*E-mail: [email protected]Cite this: Chem. Mater. 2015, 27, 5, 1448–1451Publication Date (Web):February 19, 2015Publication History Received6 January 2015Revised17 February 2015Published online23 February 2015Published inissue 10 March 2015https://pubs.acs.org/doi/10.1021/acs.chemmater.5b00041https://doi.org/10.1021/acs.chemmater.5b00041rapid-communicationACS PublicationsCopyright © 2015 American Chemical SocietyRequest reuse permissionsArticle Views4336Altmetric-Citations123LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Perovskites,Solar cells,Solutions,Thermal annealing,Thin films Get e-Alerts
ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway (2020)

The accumulation of damaged mitochondria causes the death of dopaminergic neurons. The Parkin-mediated mitophagy pathway functions to remove these mitochondria from cells. Targeting this pathway represents a therapeutic strategy for several neurodegenerative diseases, most notably Parkinson's disease. We describe a discovery pipeline to identify small molecules that increase Parkin recruitment to damaged mitochondria and ensuing mitophagy. We show that ROCK inhibitors promote the activity of this pathway by increasing the recruitment of HK2, a positive regulator of Parkin, to mitochondria. This leads to the increased targeting of mitochondria to lysosomes and removal of damaged mitochondria from cells. Furthermore, ROCK inhibitors demonstrate neuroprotective effects in flies subjected to paraquat, a parkinsonian toxin that induces mitochondrial damage. Importantly, parkin and rok are required for these effects, revealing a signaling axis which controls Parkin-mediated mitophagy that may be exploited for the development of Parkinson's disease therapeutics.
Failure mechanisms of flash cell in program/erase cycling (2002)

The impact of program/erase cycling on flash memory cell is reviewed considering both performance degradation of the typical bit and the evolution of the erase threshold voltage distribution of the whole memory array. Emphasis is given to the failure mechanisms which affect flash memory endurance: the erratic erase phenomenon is discussed with reference to the model recently reported in the literature and a new degradation mechanism, induced by parasitic drain stress conditions in program/erase cycling, is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Differential expression of specific microRNA and their targets in acute myeloid leukemia (2010)

Acute myeloid leukemia (AML) the most common acute leukemia in adults is characterized by various cytogenetic and molecular abnormalities. However, the genetic etiology of the disease is not yet fully understood. MicroRNAs (miRNA) are small noncoding RNAs which regulate the expression of target mRNAs both at transcriptional and translational level. In recent years, miRNAs have been identified as a novel mechanism in gene regulation, which show variable expression during myeloid differentiation. We studied miRNA expression of leukemic blasts of 29 cases of newly diagnosed and genetically defined AML using quantitative reverse transcription polymerase chain reaction (RT-PCR) for 365 human miRNA. We showed that miRNA expression profiling reveals distinctive miRNA signatures that correlate with cytogenetic and molecular subtypes of AML. Specific miRNAs with consolidated role on cell proliferation and differentiation such as miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. We observed a significant differentially expressed miRNA profile that characterizes two subgroups of AML with different mechanism of leukemogenesis: core binding factor (CBF) and cytogenetically normal AML with mutations in the genes of NPM1 and FLT3-ITD. We demonstrated, for the first time, the inverse correlation of expression levels between miRNA and their targets in specific AML genetic groups. We suggest that miRNA deregulation may act as complementary hit in the multisteps mechanism of leukemogenesis offering new therapeutic strategies.
Shadow patching: Minimizing maintenance windows in a virtualized enterprise environment (2014)

Software is growing bigger and more complex, which results in bugs and defects being no longer dealt as exceptions, but rather as normal artifacts in a software's lifecycle. In fact, many patches are released by vendors on a preset schedule. This implies that managing patches in a correct and timely manner has become an important factor in smoothly running an IT environment. However, when a patch is applied, the affected software is often required to stop temporarily, which can cause a disruption of service. The down time is commonly called a maintenance window. Although sophisticated live patching techniques have been previously proposed, their applicability in practice is very limited. In this paper, we propose a novel patch management technique based on commonly available virtualization capabilities. It allows system administrators to perform a majority of the patch work outside of the maintenance window, such as downloading patches, installing them, and performing post-installation testing and fixes. By capturing the disk activities and replaying them during the actual maintenance window, we can transform a complex software patching operation to a series of more deterministic file I/O operations, and thus, reducing maintenance window from hours to minutes.
Protein Identification by Tandem Mass Spectrometry and Sequence Database Searching (2006)

The shotgun proteomics strategy, based on digesting proteins into peptides and sequencing them using tandem mass spectrometry (MS/MS), has become widely adopted. The identification of peptides from acquired MS/MS spectra is most often performed using the database search approach. We provide a detailed description of the peptide identification process and review the most commonly used database search programs. The appropriate choice of the search parameters and the sequence database are important for successful application of this method, and we provide general guidelines for carrying out efficient analysis of MS/MS data. We also discuss various reasons why database search tools fail to assign the correct sequence to many MS/MS spectra, and draw attention to the problem of false-positive identifications that can significantly diminish the value of published data. To assist in the evaluation of peptide assignments to MS/MS spectra, we review the scoring schemes implemented in most frequently used database search tools. We also describe statistical approaches and computational tools for validating peptide assignments to MS/MS spectra, including the concept of expectation values, reversed database searching, and the empirical Bayesian analysis of PeptideProphet. Finally, the process of inferring the identities of the sample proteins given the list of peptide identifications is outlined, and the limitations of shotgun proteomics with regard to discrimination between protein isoforms are discussed.
Development and Mapping of 2240 New SSR Markers for Rice (Oryza sativa L.) (2002)

A total of 2414 new di-, tri- and tetra-nucleotide non-redundant SSR primer pairs, representing 2240 unique marker loci, have been developed and experimentally validated for rice (Oryza sativa L.). Duplicate primer pairs are reported for 7% (174) of the loci. The majority (92%) of primer pairs were developed in regions flanking perfect repeats > or = 24 bp in length. Using electronic PCR (e-PCR) to align primer pairs against 3284 publicly sequenced rice BAC and PAC clones (representing about 83% of the total rice genome), 65% of the SSR markers hit a BAC or PAC clone containing at least one genetically mapped marker and could be mapped by proxy. Additional information based on genetic mapping and "nearest marker" information provided the basis for locating a total of 1825 (81%) of the newly designed markers along rice chromosomes. Fifty-six SSR markers (2.8%) hit BAC clones on two or more different chromosomes and appeared to be multiple copy. The largest proportion of SSRs in this data set correspond to poly(GA) motifs (36%), followed by poly(AT) (15%) and poly(CCG) (8%) motifs. AT-rich microsatellites had the longest average repeat tracts, while GC-rich motifs were the shortest. In combination with the pool of 500 previously mapped SSR markers, this release makes available a total of 2740 experimentally confirmed SSR markers for rice, or approximately one SSR every 157 kb.
Prognostic relevance of gene signatures in high-grade serous ovarian carcinoma. (2013)

5510 Background: Transcriptional profiling of ovarian cancers has proven to be complex. As such it has been difficult to validate existing signatures across studies. Cancer Genome Atlas (TCGA) researchers have identified four molecular subtypes of high-grade serous ovarian cancer (HGSOC). However, survival duration did not differ significantly for the TCGA subtypes. Potential limitations of the TCGA data include short clinical follow-up (45% were alive at the time of last follow-up) and the need to unify gene expression measures from multiple platforms. Methods: Clinically annotated stage-II–IV HGSOC samples (n = 175) with >70% tumor cell content were profiled using the Agilent Whole Human Genome 4 x 44K chip. To identify subtypes non-negative matrix factorization (NMF) of mRNA expression was performed using ~2000 genes with the highest variability across patients. In parallel differentially expressed genes were identified using the Rosetta Similarity Search Tool as well as analysis of variance based on genes known to be involved in epithelial to mesenchymal transition. Results: Median follow-up time was 35 months (range, 0–202 months, 12% were alive at the time of last follow-up). NMF clustering confirmed four HGSOC subtypes (immunoreactive, differentiated, proliferative, and mesenchymal) on the basis of gene content in the clusters. Pathway signatures with therapeutic potential were identified for individual or multiple subtypes. Survival differed significantly between the four molecular subgroups in univariate (Hazard Ratio [HR] 2.4, 95% CI 1.5-4.1, p = 0.007) and multivariate (HR 2.3, 95% CI 1.3-4.0, p = 0.003) analyses when accounting for age, stage, grade, and postoperative residual tumor. Using the supervised clustering approach two distinct molecular subtypes of HGSOC based on epithelial and mesenchymal gene expression signatures were identified with significantly different survival outcomes. Conclusions: Here we independently validate and expand upon the molecular TCGA classification of HGSOC. The potential of these two prognostic classifiers may lie in their ability to recognize categories of patients that are more likely to respond to particular therapies.
Lipid nanoparticles for the delivery of poorly water-soluble drugs (2010)

Colloidal lipid emulsions and solid lipid nanoparticles are interesting options for the delivery of poorly water-soluble drug substances. Their specific physicochemical properties need, however, to be carefully considered to provide a rational basis for their development into effective carrier systems for a given delivery task.
Nisin: A Novel Substrate for Glutathione S‐Transferase Isolated from Fresh Beef (2002)

ABSTRACT: Little success has been reported on the use of the antimicrobial peptide nisin in meat products. Previous research in our laboratory hypothesized that nisin is inactivated in raw meat systems by an enzymatic reaction with glutathione. We isolated glutathione S‐transferase from fresh beef muscle and examined the in vitro enzymatic reaction between nisin and glutathione. The products of the reaction were analyzed by antibacterial‐activity assays and MALDI‐TOF MS. Under optimum reaction temperatures, the results showed that 3 glutathione molecules could conjugate to 1 nisin molecule, suggesting that multiple dehydro residues are involved. Assays for antibacterial activity confirmed that all activity was lost. Results support the inactivation of nisin by glutathione.
PLANS AND DEVELOPMENTS FOR AIR TRAFFIC SYSTEMS (1976)

These Proceedings include the papers presented at a Symposium of the AGARD Guidance and Control Panel, Held in Cambridge, Massachusetts, USA, 20-23 May 1975. Forty papers were presented on the following topics: Navigation, Surveillance, Automation, Airport Capacity and Surface Surveillance, Approach and Landing, Advanced Concepts and System Performance Measures. The proceedings include DIscussions, a Conference Overview and Closing Remarks. (Author)
Chlorosilanols ‐ more stable than you think ‐Shown with <sup>29</sup> Si NMR (1993)

The chlorosilanols ClnSi(OH)4-n (n = 3 … 1) can be seen by 29Si NMR spectroscopy during a partial hydrolysis-condensation of silicon tetrachloride in the NMR tube.
Journée d'étude internationale sur les droits du patient, 14 décembre (2012)

Le 14 décembre prochain, l'Institut François Gény et le GEIE LuxLorSan organisent une journée d'étude internationale sur les droits du patient. L'objectif de cette journée est de comparer les droits français, belge et luxembourgeois. Le programme de cette journée est disponible sur le site Santé Transfrontalière.
Apoptosis occurs more frequently in metastatic foci than in primary lesions of human colorectal carcinomas: Analysis by terminal-deoxynucleotidyl-transferase-mediated dUTP-biotin nick end labeling (1996)

We examined the occurrence of apoptotic cell death in 15 advanced colorectal carcinomas with lymph-node and/or liver metastases by terminal-deoxynucleotidyl-transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL). TUNEL-positive cells were used to quantify the apoptotic index (AI: percentage of TUNEL-positive cells in carcinomatous cells). Similarly, Ki-67-positive cells were used to quantify Ki-67 labeling (KI: percentage of Ki-67-positive cells in carcinomatous cells) as a proliferative index. The mean AIs of primary colorectal carcinomas, lymph-node and liver metastases were 3.5%, 5.6% and 6.2% respectively. There was a significant group difference between primary carcinomas and lymph-node or liver metastases. The mean KIs of primary colorectal carcinomas, lymph-node and liver metastases were 51.8%, 60.1% and 61.7% respectively. There was a significant group difference between primary carcinomas and lymph-node or liver metastases. In addition, there was a close positive relationship between the AI and MI per specimen. There was no apparent correlation between AI or MI and the expression of nuclear p53 of cancer cells. These results suggested that cell proliferation and loss (apoptosis) were more frequent in metastatic foci than in primary lesions, and that apoptosis might reflect not only cell loss but also the proliferative activity of human colorectal carcinomas.
Towards Collaborative Metadata Enrichment for Adaptive Web-based Learning (2013)

Abstract—In recent years we have witnessed expansion of Web 2.0. Its main feature is allowing users ’ collaboration in content creation using various means, e.g. annotations, discussions, wikis, blogs or tags. This approach has influenced also webbased learning, for which the term “Learning 2.0 ” has been introduced. In this paper we explore using tags in such systems. Tags can be used for improving of searching, categorization of web-documents, creating folksonomies and ontologies or enhancing the user-model. Another aspect of tags is that they act as a bridge between resources and users to create a social network. We integrated tags in a learning framework ALEF and experimentally evaluated their usage in education process. Keywords-Web collaboration; folksonomy; tag; learning framework
An implantable permanent left ventricular assist system for man. (1978)

A new implantable, electrically powered LV AS suitable for long-term use in man has been designed and is under development. The system is based on the well developed high-efficiency pulsed solenoid technology and a careful a priori systems approach to integration of the energy converter with a suitable blood pump. A novel dual pusher-plate sac-type blood pump with significant advantages in hemodynamics, antithrombogenicity and durability has been designed. The complementary energy converter, a pivoted-armature dual-gap solenoid, addresses weaknesses in previous designs while retaining all the good features of its forerunners and provides for the first time a truly integrated implantable circulatory assist system for man.
Some plant species as Christmas-symbols (2014)

U ovom clanku prikazane su pojedine najcesce biljne vrste kao simboli Božica: Ilex aquifolium L., Euphorbia pulcherrima Willd. ex Klotzsch, Viscum album L. i Ruscus hypoglossum L. Navedena su njihova morfoloska obilježja, rasprostranjenost te povijesna povezanost s Božicem.
Effectiveness and Users' Experience of Obfuscation as a Privacy-Enhancing Technology for Sharing Photos (2017)

Current collaborative photo privacy protection solutions can be categorized into two approaches: controlling the recipient, which restricts certain viewers' access to the photo, and controlling the content, which protects all or part of the photo from being viewed. Focusing on the latter approach, we introduce privacy-enhancing obfuscations for photos and conduct an online experiment with 271 participants to evaluate their effectiveness against human recognition and how they affect the viewing experience. Results indicate the two most common obfuscations, blurring and pixelating, are ineffective. On the other hand, inpainting, which removes an object or person entirely, and avatar, which replaces content with a graphical representation are effective. From a viewer experience perspective, blurring, pixelating, inpainting, and avatar are preferable. Based on these results, we suggest inpainting and avatar may be useful as privacy-enhancing technologies for photos, because they are both effective at increasing privacy for elements of a photo and provide a good viewer experience.
Survival of the Fittest: The Relationship of (p)ppGpp With Bacterial Virulence (2020)

The signaling nucleotide (p)ppGpp has been the subject of intense research in the past two decades. Initially discovered as the effector molecule of the stringent response, a bacterial stress response that reprograms cell physiology during amino acid starvation, follow-up studies indicated that many effects of (p)ppGpp on cell physiology occur at levels that are lower than those needed to fully activate the stringent response, and that the repertoire of enzymes involved in (p)ppGpp metabolism is more diverse than initially thought. Of particular interest, (p)ppGpp regulation has been consistently linked to bacterial persistence and virulence, such that the scientific pursuit to discover molecules that interfere with (p)ppGpp signaling as a way to develop new antimicrobials has grown substantially in recent years. Here, we highlight contemporary studies that have further supported the intimate relationship of (p)ppGpp with bacterial virulence and studies that provided new insights into the different mechanisms by which (p)ppGpp modulates bacterial virulence.
A dynamic hashing approach to build the de bruijn graph for genome assembly (2013)

The development of next-generation sequencing technologies has revolutionized the genome research and given rise to the explosive increase of DNA sequencing throughput. However, due to the continuing explosive growth of short-read database, these technologies face the challenges of short overlap and high throughput. The de Bruijn graph is particularly suitable for short-read assemblies, and its advantage is that the graph size will not be affected by the high redundancy of deep read coverage. With this character, the fragment assembly is cast as finding a path visiting every edge in the graph exactly once. In this paper, we present a new method to accelerate the genome assembly procedure. We have used a distributed dynamic hashing approach to construct the de Bruijn graph from short-read data. Evaluations using three paired-end datasets show that, our method outperforms previous parallel and distributed assemblers on a CPU cluster system.
Application of reed-solomon codes with erasure decoding to type-II hybrid ARQ transmission (2004)

Hybrid ARQ protocols are capable of improving the robustness and throughput of a mobile wireless communication system when a feedback channel is available. In this paper a type-II hybrid ARQ protocol is implemented with a punctured Reed-Solomon (RS) code to result in a rate-compatible system. It is proposed to use side-information provided by pilot symbols to flag symbol erasures, and perform erasure decoding of rate-compatible RS codes. Throughput simulation results show that when using errors-only decoding, rate-compatible punctured RS codes outperform their constituent punctured RS codes. When comparing errors-only decoding to erasure decoding of the rate-compatible RS codes, a power savings is observed when erasure decoding is employed. The specific gain achieved however, is dependant on the average signal-to-noise ratio and constituent set of punctured RS codes.
Evaluation of processed green and ripe mango peel and pulp flours (<i>Mangifera indica</i> var. Chokanan) in terms of chemical composition, antioxidant compounds and functional properties (2011)

Results of this study showed mango peel flour to be a rich source of dietary fiber with good antioxidant and functional properties, which could be a useful ingredient for new functional food formulations.
Wavelet coding of image using quadtree representation and block entropy coding (2002)

A new efficient image coding scheme, based on quadtree representation and block entropy coding (QRBEC), for encoding the wavelet transform coefficients of images is presented. The property of HVS is also incorporated into the quantization process. In addition, how to flexibly control the quantization level as well as output bitrate of the coder is also investigated. The coding efficiency of the coder is quite competitive with the well-known EZW coder, and requires less computation burden. The proposed coding scheme can also be applied in image sequence coding, resulting in satisfactory performance.