gebhart/patrepeval huggingface dataset:
Thermospray interface for liquid chromatography/mass spectrometry (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermospray interface for liquid chromatography/mass spectrometryC. R. Blakley and M. L. VestalCite this: Anal. Chem. 1983, 55, 4, 750–754Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://doi.org/10.1021/ac00255a036RIGHTS & PERMISSIONSArticle Views961Altmetric-Citations594LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Long-Term Storage of Salivary Cortisol Samples at Room Temperature (1992)

Collection of saliva samples for the measurement of cortisol during space flights provides a simple technique for studying changes in adrenal function due microgravity. In the present work, several methods for preserving saliva cortisol at room temperature were investigated using radioimmunoassays for determining cortisol in saliva samples collected on a saliva-collection device called Salivettes. It was found that a pretreatment of Salivettes with citric acid resulted in preserving more than 85 percent of the salivary cortisol for as long as six weeks. The results correlated well with those for a sample stored in a freezer on an untreated Salivette.
The sound of silence (2013)

A list of the dynamically changing group membership of a meeting supports a variety of meeting-related activities. Effortless content sharing might be the most important application, but we can also use it to provide business card information for attendees, feed information into calendar applications to simplify scheduling of follow-up meetings, populate the membership of collaborative editing applications, mailing lists, and social networks, and perform many other tasks.
Flexible Dielectric Waveguide for mm Application using Gore-Tex¯ Expanded Ptfe Dielectric (1981)

A Dielectric waveguide in a cable form fabricated from polytetrafluoroethylene (PTFE) is discussed. The cable construction is a composite of expanded PTFE open cell structure material arranged in such a way that the dielectric constant of cable decreases from the core to the outer surface.
Nuclear PRMT5, cyclin D1 and IL-6 are associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with p16-status (2017)

Protein arginine methyltransferase-5 (PRMT5) plays an important role in cancer progression by repressing the expression of key tumor suppressor genes via the methylation of transcriptional factors and chromatin-associated proteins. However, very little is known about the expression and biological role of PRMT5 in head and neck cancer. In this study, we examined expression profile of PRMT5 at subcellular levels in oropharyngeal squamous cell carcinoma (OPSCC) and assessed its correlation with disease progression and patient outcome. Our results show that nuclear PRMT5 was associated with poor overall survival (p < 0.012) and these patients had 1.732 times higher hazard of death (95% CI: 1.127-2.661) as compared to patients in whom PRMT5 was not present in the nucleus of the tumors. Nuclear PRMT5 expression was inversely correlated with p16-status (p < 0.001) and was significantly higher in tumor samples from patients who smoked > 10 pack-years (p = 0.013). In addition, nuclear PRMT5 was directly correlated with cyclin D1 (p = 0.0101) and IL-6 expression (p < 0.001). In a subgroup survival analysis, nuclear PRMT5-positive/IL-6-positive group had worst survival, whereas nuclear PRMT5-negative/IL-6-negative group had the best survival. Similarly, patients with p16-negative/nuclear PRMT5-positive tumors had worse survival compared to patients with p16-positive/nuclear PRMT5-negative tumors. Our mechanistic results suggest that IL-6 promotes nuclear translocation of PRMT5. Taken together, our results demonstrate for the first time that nuclear PRMT5 expression is associated with poor clinical outcome in OPSCC patients and IL-6 plays a role in the nuclear translocation of PRMT5.
The investigation of recessed channel SOI devices (1998)

Recessed channel SOI devices were investigated. In this paper, the structure and processing of such devices is described in detail. The characteristics of a SOI MOSFET using recessed channel technology are much better than normal thick non-depleted and thin-film fully depleted SOI MOSFETs. The 0.15/spl sim/4.0 /spl mu/m recessed channel SOI MOSFETs with a silicon channel film of 70 nm and a source/drain silicon film of 160 nm are developed using a submicron process. The transconductance and drain current are increased by 40% more than thin-film fully depleted SOI MOSFETs.
Computational and Experimental Analysis of Pinch-Off and Scaling (2002)

Pinch-off and scaling during drop formation are studied using high-accuracy computation and ultrafast, high-resolution imaging. The interface of a water drop (viscosity mu is approximately 1 cP) is shown to overturn prior to breakup for the first time in experiments, well before the dynamics transitions from the potential flow (PF) to the inertial-viscous (IV) regime. A drop of 83% glycerol-water solution (mu is approximately 85 cP) is shown to exhibit a transition from the PF to the IV regime both computationally and experimentally. The computed value of the minimum neck radius in the latter case follows Eggers's universal solution until it becomes unstable.
The Lipoxygenase of Reticulocytes (1979)

A lipoxygenase has been purified from rabbit reticulocyte-rich anaemic blood cells. It possesses a molecular weight of 78 000 and an isoelectric point of 5.5 and contains 5% neutral sugars and two iron atoms per enzyme molecule. The lipoxygenase has proved to be identical with the inhibitors of respiratory proteins described formerly. The actions of the lipoxygenase on linoleic acid, phospholipids, mitochondrial and erythrocyte membranes and electron transfer particles were studied. A special feature of the reticulocyte lipoxygenase is the suicidal character of its action on lipids. With electron transfer particles the reticulocyte lipoxygenase causes a loss of acid-labile sulfur which accompanies respiratory inhibition; the strong respiratory inhibition is not exerted by soybean lipoxygenase. The reticulocyte lipoxygenase acts preferably on mitochondrial membranes as compared with cell membranes of the erythrocyte; erythrocyte cytosol moderates the action on mitochondrial membranes. Furthermore, the lipoxygenase reaction can concomitantly and irreversibly inactivate sulfhydryl enzymes as demonstrated with muscle glyceraldehyde-3-phosphate dehydrogenase. The occurrence of the lipoxygenase here described is restricted to reticulocytes; very low amounts were observed in bone marrow and no lipoxygenase was detectable in normal blood. During the course of an experimental anaemia the lipoxygenase is produced owing to superinduction in large amounts, which may persist for a long time since they escape inactivation. Preliminary evidence was obtained for the occurrence of other lipoxygenases in tissues of lung, spleen, kidney and also epithelial tumours.
A fault-tolerant multiprocess controller for magnetic bearings (1988)

A fault-tolerant microprocessor system designed to provide digital control for an active magnetic bearing is described. This particular control problem demands significant processing power, is easily divided into relatively independent parallel tasks, and cannot tolerate controller failures. The overall system requirements and architecture are described, as is the design of the digital control module and the analog I/O board. The fault tolerance of the system is evaluated. Extensive computer simulations of system reliability models verified that the design satisfies all of the reliability requirements. Although the system was designed for a specific problem, much effort was expended to make it general enough for applications to a wide range of real-time applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Challenges of Machine Learning Based Monitoring for Industrial Control System Networks (2012)

Detecting network intrusions and anomalies in industrial control systems is growing in urgency. Such systems used to be isolated but are now being connected to the outside world. Even in the case of isolated networks, privileged users may still present various threats to the system, either accidentally or intentionally. Also malfunctions in devices may cause anomalous traffic. Anomaly detection based network monitoring and intrusion detection systems could be capable of discerning normal and aberrant traffic in industrial control systems, detecting security incidents in an early phase. In this paper we discuss the challenges for such a monitoring system. One of the challenges is which features best differentiate between anomalous and normal behaviour. In the analysis, special focus is placed on this selection.
A Helix Swapping Study of Two Protein Cages (2009)

Protein cages have been the focus of studies across multiple scientific disciplines. They have been used to deliver drugs, as templates for nanostructured materials, as substrates in the development of bio-orthogonal chemistry, and to restrict diffusion to study spatially confined reactions. Although their monomers fold into four-helix bundle structures, two cage proteins, DPS and BFR, self-assemble to form a 12-mer with tetrahedral symmetry and an octahedrally symmetric 24-mer, respectively. These monomers share strong similarities of both sequence and tertiary structure. However, they differ in the presence of a short additional helix. In BFR, the fifth helix is at the C-terminus and is positioned along the 4-fold symmetry axis, whereas with DPS, an extra helix helps to define the 2-fold axis in the cage and is located between the second and third helices in the monomer bundle. In an attempt to investigate if these short helices govern protein assembly, mutants were designed and produced that delete and swap these minidomains. All mutants form highly helical structures that unfold cooperatively as evidenced by thermal melting followed by circular dichroism. Dynamic light scattering, size exclusion chromatography, and sedimentation equilibrium experiments demonstrated that although many of the BFR mutants do not self-assemble and form lower-order complexes, many DPS mutants could form cages despite their unnatural design. Taken together, our data indicate that the BC helix is less important than the E helix for overall cage self-assembly, suggesting that dimerization may not play a role in nanostructure formation that is as key as previously assumed. Additionally, we found that fusing the minidomain from BFR onto DPS results in a mutant that assembles into a homogeneous population of a novel protein oligomer. This assembled cage while still formed from 12 subunits is larger in overall shape than that of the native protein.
The Synthesis of Rhodopsin from Vitamin A <sub>1</sub> (1950)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
TCM on frequency-selective fading channels: a comparison of soft-output probabilistic equalizers (2002)

Suboptimal, low-complexity nonlinear equalizer structures derived from the probabilistic symbol-by-symbol maximum a posteriori probability (MAP) algorithm and the M-ary soft-output Viterbi algorithm (SOVA) are investigated. Both algorithms deliver reliability information for each symbol. The complexity of both algorithms in their simplest form is of the order of the conventional reduced-state Viterbi equalizer with hard outputs. Simulation results for a terrestrial time-varying frequency-selective fading channel are given. Realistic channel estimation at high Doppler speeds is included. The coding gain of the investigated 8-state trellis-coded 8-PSK scheme is about 6 dB at a BER (bit error rate) of 10/sup -3/. The gain by making use of soft-decisions is about 4-5 dB at a BER of 10/sup -3/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Constant Frequency Oscillators (1931)

The manner in which the frequency of vacuum tube oscillators depends upon the operating voltages is discussed. The theory of the dependence is derived and is shown to indicate methods of causing the frequency to be independent of the operating voltages. These methods are applied in detail to the more commonly used oscillator circuits. Experimental data are cited which show the degree of frequency stability which may be expected as a result of application of the methods outlined in the theory, and also show that the best adjustment is in substantial agreement with that predicted by theory. With a carefully built and adjusted oscillator the effects of normal variations in the operating voltages are negligible in comparison with the effects of temperature variations resulting from the changed operating currents. Methods of preventing these latter effects are not discussed in the present paper. The appendix contains an analysis of the conditions under which the performance of an oscillator may be represented by the use of linear circuit equations.
HYTECH: the next generation (2002)

We describe a new implementation of HYTECH, a symbolic model checker for hybrid systems. Given a parametric description of an embedded system as a collection of communicating automata, HYTECH automatically computes the conditions on the parameters under which the system satisfies its safety and timing requirements. While the original HYTECH prototype was based on the symbolic algebra tool Mathematica, the new implementation is written in C++ and builds on geometric algorithms instead of formula manipulation. The new HYTECH offers a cleaner and more expressive input language, greater portability, superior performance (typically two to three orders of magnitude), and new features such as diagnostic error-trace generation. We illustrate the effectiveness of the new implementation by applying HYTECH to the automatic parametric analysis of the generic railroad crossing benchmark problem and to an active structure control algorithm.
Elongation factor Tu.ribosome dependent GTP hydrolysis: elucidation of the role of the AA-tRNA 3' terminus and site(s) involved in the inducing of the GTPase reaction (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElongation factor Tu.ribosome dependent GTP hydrolysis: elucidation of the role of the AA-tRNA 3' terminus and site(s) involved in the inducing of the GTPase reactionPrakash Bhuta, Gyanendra Kumar, and Stanislav ChladekCite this: Biochemistry 1982, 21, 5, 899–905Publication Date (Print):March 2, 1982Publication History Published online1 May 2002Published inissue 2 March 1982https://pubs.acs.org/doi/10.1021/bi00534a014https://doi.org/10.1021/bi00534a014research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimizing All-to-All Collective Communication by Exploiting Concurrency in Modern Networks (2005)

The paper proposes a novel approach for optimizing performance of all-to-all collective communication by taking advantage of concurrency available in modern networks such as Infiniband or Quadrics. Using the MPI AllGather operation as an example, we describe how network concurrency can be exploited in an optimized implementation of this operation. For example, compared to leading MPI implementations for a 32-KB message on 128 processors, our new algorithm yields a 65% improvement on the Infiniband at Virginia Tech and an 89% improvement on the Quadrics cluster at Pacific Northwest National Laboratory.
Non‐A, non‐B hepatitis associated with blood transfusion (1985)

Posttransfusion hepatitis of the non-A, non-B variety continues to be a significant problem in current hemotherapy. This disorder is many times more common than transfusion-associated disease caused by hepatitis B virus, cytomegalovirus, and Epstein-Barr virus, and also seems to be viral in origin. Several potential etiological agents have been implicated, but none has been identified with certainty, despite concerted efforts at doing so. Clinical disease is usually attended by few symptoms and signs, but evolution to chronic liver disease is distressingly common; over 50 percent of all cases of non-A, non-B posttransfusion hepatitis manifest this transition. Efforts at prevention of non-A, non-B hepatitis associated with blood transfusion have thus far been hampered by the lack of reliable laboratory markers for carriers of this disease, and controversy exists over the implementation of screening tests on blood donors, using such nonspecific indicators of possible viral carriage as serum alanine aminotransferase levels. It is probable, however, that simple measures such as more restrained blood usage, encouraged by greater educational efforts within the medical community, could be beneficial in minimizing the number of new cases of non-A, non-B posttransfusion hepatitis seen each year in the United States.
The Sleep-Evoked Decrease of Body Temperature (1993)

The circadian rhythm of deep body temperature consists of both an endogenous component and evoked components resulting from exogenous influences. Previous studies of the sleep-evoked effect have failed to control confounding influences, so that the effect of sleep per se has not been established. In the present study, eight good sleepers had their rectal temperatures recorded for 24 hours in each of two laboratory conditions employing a constant routine to control exogenous influences. Sleep was allowed at night in one condition. Following sleep onset, body temperature dropped more rapidly and remained lower than when wakefulness continued over the same time, resulting in a mean sleep-evoked decrease of 0.31 +/- 0.09 degree C. Fourier regression analysis showed a significant 24-hour (circadian) temperature rhythm, together with a 12-hour harmonic rhythm, in each condition. Circadian rhythm parameters were also altered by the sleep-evoked (or masking) effect, with the amplitude increased and the mean decreased when subjects slept at night in the constant routine. It was suggested that a constant routine methodology be used in studies of circadian rhythm differences and that Fourier regression be used in preference to simple cosine curve fitting to give a better approximation of the temperature rhythm.
Clinical features and pathophysiological basis of sensory neuronopathies (ganglionopathies) (2004)

Abstract Sensory ganglionopathies have a frequent association with neoplastic disorders (paraneoplastic subacute sensory neuronopathy, or SSN) or dysimmune disorders (Sjögren's syndrome, SS; Miller Fisher syndrome; and Bickerstaff's brainstem encephalitis, BBE), with drugs, such as cisplatin or pyridoxine, and with inherited disorders with degeneration of dorsal root ganglion cells. Unsteady gait and pseudoathetoid movements of the hand are the distinctive signs encountered in these disorders. The chronic disorders are characterized by non–length‐dependent abnormalities of sensory nerve action potentials (SNAPs) and differ from other sensory neuropathies in showing a global, rather than distal, decrease in SNAP amplitudes. This review focuses on recent advances in defining the mechanisms involved in sensory ganglionopathies. Specific topics include a summary of their clinical features, pathological findings, and immunopathology. In SSN, early diagnosis by the detection of anti‐Hu antibodies and early treatment of the cancer gives the best chance of stabilizing the disorder. In SS sensory ganglionitis, response to treatment has been disappointing, but immunomodulating treatments are emerging. The immunological profile common to BBE and Fisher syndrome supports a common pathogenesis. In toxic sensory neuronopathy, no treatment is available. The differential diagnosis involves separating sensory ganglionopathies from other ataxic polyneuropathies, such as infectious neuropathies, sensory neuropathies with various autoantibodies, and the neuropathies seen in celiac disease. Muscle Nerve 30:255–268, 2004
Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology (2009)

Polo-like kinases (PLKs) are a group of highly conserved serine/threonine protein kinases that play a key role in processes such as cell division and checkpoint regulation of mitosis. About 80% of human tumors, of various origins, express high levels of PLK transcripts. However, PLK mRNA is mostly absent in surrounding healthy tissues. Overexpression of PLK is associated with a poor prognosis in several tumor types and a lower overall survival rate. The overexpression of PLKs in human tumors, but not in healthy nondividing cells, makes them an attractive, selective target for cancer drug development. PLK inhibitors interfere with different stages of mitosis, such as centrosome maturation, spindle formation, chromosome separation, and cytokinesis. They induce mitotic chaos and severely perturb cell cycle progression, eventually leading to cancer cell death. Several PLK inhibitors are in development and are undergoing evaluations as potential cancer treatments. This review includes an overview of PLK inhibitors in early clinical development (i.e., BI 2536, BI 6727, GSK461364, ON 019190.Na, and HMN-214) and in advanced preclinical development (i.e., ZK-thiazolidinone, NMS-1, CYC-800, DAP-81, and LC-445). If proof of principle is confirmed in large studies, PLK inhibitors will offer a new targeted antitumor therapy for cancer patients.