gebhart/patrepeval huggingface dataset:
Transmitter Detection Technique with Spreading Code Slicing Scheme for AT-DMB System (2009)

Evidence that transforming growth factor beta (TGF-beta) influences pattern formation in the developing mammary gland and negatively regulates ductal growth is reviewed. In the mouse, overexpression of TGF-beta transgenes during puberty reduces the rate of growth of the ductal tree and simplifies the pattern of arborization, while expression during pregnancy also interferes with lactation. Expression studies in the normal mouse gland indicate that TGF-beta is synthesized in the mammary epithelium, with the three isoforms showing somewhat different spatial and temporal distributions. Exogenous TGF-beta applied directly to the gland in situ inhibits epithelial cell division within hours, and strongly stimulates extracellular matrix synthesis over a longer time course. Normal human breast cells as well as certain breast cancer cell lines also secrete TGF-beta and are themselves inhibited by it, suggesting an autoregulatory feedback circuit, that in some cases appears to be modulated by estradiol. Taken together, the evidence suggests a model in which growth and patterning of the mammary ductal tree are regulated, at least in part, by TGF-beta operating through an autocrine feedback mechanism and by paracrine circuits associated with epithelial-stromal interactions.
The development of copper wire bonding for plastic molded semiconductor packages. (1986)

Gold wire bonding has been employed in mass production process of semiconductors because the ball bonding system using gold wire can be very effectively utilized on the aspect of productivity. There is, however, an increasing demand for development of a new technology to replace gold wire with other materials in the light of further enhancing the reliability of devices and saving the material cost. In this background, the authors developed the copper wire bonding technology for plastic molded semiconductor, fundamentally on the basis of employing the hardware system for conventional gold wire bonding, Primarily, the ball formatio technology and ball bonding technology were major subjects of development. These two problems were successfully solved by the development of power source for S.P. discharge, use of hot capillary tip, control of physical properties of aluminum pad, and other techniques.Furthermore, as a result of steady and versatile fundamental researches and applied studies such as material development, process engineering development, quality assurance and hardware development, the practicability of copper wire bonding has been confirmed. This paper mainly refers to the studies of its process.
Assembly‐Based Vulnerability of Buildings and Its Use in Performance Evaluation (2001)

Assembly‐based vulnerability (ABV) is a framework for evaluating the seismic vulnerability and performance of buildings on a building‐specific basis. It utilizes the damage to individual building components and accounts for the building's seismic setting, structural and nonstructural design and use. A simulation approach to implementing ABV first applies a ground motion time history to a structural model to determine structural response. The response is applied to assembly fragility functions to simulate damage to each structural and nonstructural element in the building, and to its contents. Probabilistic construction cost estimation and scheduling are used to estimate repair cost and loss‐of‐use duration as random variables. It also provides a framework for accumulating post‐earthquake damage observations in a statistically systematic and consistent manner. The framework and simulation approach are novel in that they are fully probabilistic, address damage at a highly detailed and building‐specific level, and do not rely extensively on expert opinion. ABV is illustrated using an example pre‐Northridge welded‐steel‐moment‐frame office building.
Measurement of Ceruloplasmin from Its Oxidase Activity in Serum by Use of o-Dianisidine Dihydrochloride (1974)

Abstract We have developed a new method for determination of serum ceruloplasmin from its oxidase activity, in which o-dianisidine dihydrochloride is used as substrate. o-Dianisidine dihydrochloride is more stable than is the more widely used p-phenylenediamine substrate, and forms a stable product that is measured at 540 nm. Correlation was good between results of this method and those obtained with both a p-phenylenediamine substrate method (r = 0.98) and a radial immunodiffusion procedure (r = 0.97). There is little or no interference from reducing or colored components of serum. The coefficient of variation (day-to-day) for the method was 4.2%. A normal range of 62-140 U/ liter has been determined by the reported method.
Optimizing In-Order Execution of Continuous Queries over Streamed Sensor Data (2004)

The widespread use of sensor networks in scientific and engineering applications leads to increased demand on the efficient computation of the collected sensor data. Recent research in sensor and stream data systems adopts the notion of sliding windows to process continuous queries over infinite sensor readings. Ordered processing of input data is essential during query execution for many application scenarios. In this paper we present three approaches for ordered execution of continuous sliding window queries over sensor data. The first approach enforces ordered processing at the input side of the query execution plan. In the second approach we utilize the advantage of out-of-order execution to optimize query operators and enforce an ordered release of the output results. The third approach is adaptive and switches between the first and second approaches to achieve the best overall performance with current input arrival rates and level of multiprogramming. We study the performance of the proposed approaches both analytically and experimentally and under a variety of conditions such as the asynchronous arrival of input data, and various levels of multiprogramming. Our performance study is based on an extensive set of experiments using a realization of the proposed approaches in a prototype stream query processing system.
Reduction of Ovomucoid Immunogenic Activity on Peptic Fragmentation and Heat Denaturation (1985)

Journal Article Reduction of Ovomucoid Immunogenic Activity on Peptic Fragmentation and Heat Denaturation Get access Tsukasa Matsuda, Tsukasa Matsuda Department of Food Science and Technology, School of Agriculture, Nagoya University, Chikusa-ku, Nagoya 464, Japan Search for other works by this author on: Oxford Academic Google Scholar Kazuko Tsuruta, Kazuko Tsuruta Department of Food Science and Technology, School of Agriculture, Nagoya University, Chikusa-ku, Nagoya 464, Japan Search for other works by this author on: Oxford Academic Google Scholar Yumiko Nakabe, Yumiko Nakabe Department of Food Science and Technology, School of Agriculture, Nagoya University, Chikusa-ku, Nagoya 464, Japan Search for other works by this author on: Oxford Academic Google Scholar Ryo Nakamura Ryo Nakamura Department of Food Science and Technology, School of Agriculture, Nagoya University, Chikusa-ku, Nagoya 464, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 49, Issue 7, 1 July 1985, Pages 2237–2241, https://doi.org/10.1080/00021369.1985.10867063 Published: 01 July 1985 Article history Received: 09 January 1985 Published: 01 July 1985
The Accumulation of Oleosins Determines the Size of Seed Oilbodies in <i>Arabidopsis</i> (2006)

We investigated the role of the oilbody proteins in developing and germinating Arabidopsis thaliana seeds. Seed oilbodies are simple organelles comprising a matrix of triacylglycerol surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Indirect observations have suggested that oleosins maintain oilbodies as small single units preventing their coalescence during seed desiccation. To understand the role of oleosins during seed development or germination, we created lines of Arabidopsis in which a major oleosin is ablated or severely attenuated. This was achieved using RNA interference techniques and through the use of a T-DNA insertional event, which appears to interrupt the major (18 kD) seed oleosin gene of Arabidopsis and results in ablation of expression. Oleosin suppression resulted in an aberrant phenotype of embryo cells that contain unusually large oilbodies that are not normally observed in seeds. Changes in the size of oilbodies caused disruption of storage organelles, altering accumulation of lipids and proteins and causing delay in germination. The aberrant phenotypes were reversed by reintroducing a recombinant oleosin. Based on this direct evidence, we have shown that oleosins are important proteins in seed tissue for controlling oilbody structure and lipid accumulation.
Wide-Area IP Network Mobility (2008)

IP network mobility is emerging as a major paradigm for providing continuous Internet access while a set of users are on the move in a transportation system. The intense interest on its support has led to the establishment of the NEMO IETF working group and a test-deployment by a major airline equipment vendor - Boeing - on major airline routes. However, the previously proposed solutions are either inefficient or may cause instability to the global Internet. We propose WINMO, a simple, systematic, novel solution for wide-area IP network mobility using techniques including route aggregation, scoped update propagation, and packet mobility states. Our solution provides efficient routing when users travel both across autonomous systems (ASes) and within a single AS, generates minimal global routing overhead to prevent global instability, ensures good location privacy, and helps to defend against denial-of-service attacks. Furthermore, our basic scheme (without packet mobility state) is transparent to both clients and servers. Our extensive evaluations demonstrate the effectiveness of our mobility solution.
Design of humidifying system for the powder bed of the three-dimensional printing machine (1993)

Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1993.
The Ontogeny of Thymic Independent Antibody Responses <i>in Vitro</i> in Normal Mice and Mice with an X-Linked B Cell Defect (1977)

Abstract The primary in vitro antibody response of neonatal spleen cells to three thymic independent antigens has been examined. The time of onset of responsiveness to TNP-Brucella abortus and TNP-lipopolysaccharide was significantly earlier than the onset of responsiveness to TNP-Ficoll. This ontologic sequence was not affected by T cell depletion or antigen presentation on adult macrophages. In neonatal mice bearing the X-linked CBA/N defect, the response to TNP-Brucella abortus and TNP-lipopolysaccharide was much delayed and no response to TNP-Ficoll developed. We conclude that different thymic independent antigens address different subpopulations of B cells, one of which appears earlier in ontogeny than the other.
A real-time vehicle routing system for RFID-tagged goods transportation (2008)

This paper proposes an intelligent vehicle routing system on real-time in-transit goods status information and real-time traffic flow information of road network. The system collects and extracts real-time information of in-transit goods by attached active RFID tags. Real-time traffic flow information of observed roads and the vehicle location information are fed back by the driver of cargo. Moreover, traffic flow status of unobserved roads is extracted from historical data as empirical stochastic distributions. Therefore, the optimization of vehicle route is calculated by a simulation-based optimization algorithm. In the algorithm, a computational model is built to represent the complicated vehicle routing problem, instead of traditional mathematical model. In this way, each uncertain traffic flow status of unobserved roads in the problem is simulated by a random variable generator in the computational model. The intelligent algorithm optimizes the vehicle route according to simulation outputs. Additionally, the proposed system is built on multi-agent platform under client/server software architecture. The distributed computing capability of multi-agent technology promises the approach has better operating performances. Finally, a prototype system is implemented to verify our proposal on the simulation platform.
Methicillin-Resistant <i>S. aureus</i> Infections among Patients in the Emergency Department (2006)

MRSA is the most common identifiable cause of skin and soft-tissue infections among patients presenting to emergency departments in 11 U.S. cities. When antimicrobial therapy is indicated for the treatment of skin and soft-tissue infections, clinicians should consider obtaining cultures and modifying empirical therapy to provide MRSA coverage.
A Workload Characterization Study of the 7998 World Cup Web Site (2000)

This article presents a detailed workload characterization study of the 1998 World Cup W e b site. Measurements from this site were collected over a three-month peri-od. During this time the site received l.35 billion re uests, making this the largest throu h comparison with existing characterization studies, we are able to deter-m i n e l o w W e b server workloads are evolving. W e find that improvements in the caching architecture of the World Wide W e b are changing the workloads of W e b servers, but major im rovements to that architecture are still necessary. In particu-lar, we uncover ev i lence that a better consistency mechanism is required for World Wide W e b caches. W e b workload analyzed to date. By examining a t i s extremely busy site and he 16th Federation Internationale de Football Associa-tion (FIFA) World Cup was held in France from June
Molecular biology and pharmacology of cloned opioid receptors <sup>1</sup> (1995)

The cloning and expression of DNA for the three major opioid receptor types (mu, delta, and kappa) present new research opportunities for the characterization of opioid drugs and their interactions with these receptors. Genomic and cDNA clones for opioid receptors exist for several animal species including mouse, rat, guinea pig, and human. These include clones for all three human opioid receptor types. The receptor proteins consist of about 400 amino acids and have the characteristic seven transmembrane domain structure of G-protein-coupled receptors. There is about 60% amino acid identity between opioid receptor types and about 90% identity between a receptor type cloned from different animal species. All opioid receptor types mediate the inhibition of adenylyl cyclase in response to agonist binding. Radioligand binding and functional studies using the cloned receptors tend to support current conclusions on opioid drug receptor selectivity and activity. Investigations of opioid receptor chimeras and single amino acid mutants are providing information on the ligand recognition sites of these receptors and essential support for the development of computational opioid receptor models. A molecular model of the human delta opioid receptor is included in this review.
New peltogynoids from Acacia nilotica (2008)

The genus Acacia (Leguminosae, subfamily Mimosoideae) includes some 1400 species of trees and shrubs widespread throughout the warm arid and semi-arid regions of the world. Acacia nilotica (L.) Delile belongs to the subgenus Acacia. It naturally occurs in tropical Africa, from Senegal and Egypt southwards to Mozambique and Natal, and also in Asia, from Arabia to India and Burma. A. nilotica is a more or less shrubby tree 5–20m high. This species is widely used in traditional medicine in Africa. Repeated column chromatography over silica gel of the CHCl3 soluble part of the EtOH extract obtained from the stem bark of Acacia nilotica, resulted in the isolation of the two novel peltogynans, acanilol I (1) and II (2), together with the known triterpene lupenone. The structures of the novel compounds were established on the basis of mass spectrometry and NMR experiments [1].
Distance properties of finite-impulse response channels (2000)

High-speed data communication over channels with limited bandwidth gives rise to intersymbol interference at the receiver usually resulting in a poor receiver error performance. An important parameter that determines the receiver error performance is the minimum Euclidean distance between two received sequences. Channel properties that maximize this distance are investigated. It is shown that maximum distance channels exist for any length of interference.
Vertical ozone profiles deduced from measurements of SBUS on FY-3 satellite (2010)

FY-3 卫星是一颗第二代的中国极轨道的气象学的卫星。太阳的反散射紫外更健全(SBUS ) ， FY-3 卫星上的主要收费载重之一，是一颗气象学的卫星上的第一台中国监视臭氧的仪器。作为 FY-3 的在里面轨道确认的部分，我们执行了检索 trial using 从 SBUS 的大小在 2008 年 7 月 17-30 日，和有从国家海洋、大气的管理(NOAA ) 卫星 SBUV/2 的大小和检索侧面的比较那些数据的时期期间。结果证明大小和检索侧面的精确相当好。侧面从 SBUV/2 从 SBUS 和那些检索了的臭氧的平均相对差别百分比在虡 N 敶祬 ?湩楤 以内吗？
Visualizing Dual-Modality Rendered Volumes Using a Dual-Lookup Table Transfer Function (2007)

In positron emission tomography/computed tomography (PET/CT) volume rendering, volume images are associated with individual lookup tables, which users must manipulate independently of the resultant volumes being fused. An intuitive, efficient dual-lookup table transfer function can improve the visualization of fused PET/CT renderings
D-Dupe: An Interactive Tool for Entity Resolution in Social Networks (2006)

Visualizing and analyzing social networks is a challenging problem that has been receiving growing attention. An important first step, before analysis can begin, is ensuring that the data is accurate. A common data quality problem is that the data may inadvertently contain several distinct references to the same underlying entity; the process of reconciling these references is called entity-resolution. D-Dupe is an interactive tool that combines data mining algorithms for entity resolution with a task-specific network visualization. Users cope with complexity of cleaning large networks by focusing on a small subnetwork containing a potential duplicate pair. The subnetwork highlights relationships in the social network, making the common relationships easy to visually identify. D-Dupe users resolve ambiguities either by merging nodes or by marking them distinct. The entity resolution process is iterative: as pairs of nodes are resolved, additional duplicates may be revealed; therefore, resolution decisions are often chained together. We give examples of how users can flexibly apply sequences of actions to produce a high quality entity resolution result. We illustrate and evaluate the benefits of D-Dupe on three bibliographic collections. Two of the datasets had already been cleaned, and therefore should not have contained duplicates; despite this fact, many duplicates were rapidly identified using D-Dupe's unique combination of entity resolution algorithms within a task-specific visual interface
Circulating 11β‐Hydroxysteroid Dehydrogenase Type 1 mRNA and Cardiovascular Risk Factors (2008)

11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) has been implicated in the pathogenesis of central obesity and metabolic syndrome. It has been shown that tissue-specific mRNA is present in blood, raising the possibility that quantifiable levels of 11beta-HSD1 mRNA may also be present in circulation. The aim of this study was to determine whether a relationship exists between circulating 11beta-HSD1 mRNA levels and various cardiovascular risk factors. Whole blood was collected using PAXgene Blood RNA tubes from 73 subjects. Total RNA was extracted, reverse-transcribed to cDNA, and 11beta-HSD1 mRNA was measured by quantitative real time PCR. The median BMI was 24 (range = 17-36) and the concentration of 11beta-HSD1 mRNA tended to decrease with increasing BMI (r=-0.206; P= 0.08). Multiple linear regression analysis identified BMI as an independent predictor of mRNA levels (beta=-0.412, P= 0.002). Other factors included in the analysis are age (beta= 0.952, P < 0.001), smoking (beta=-0.228, P= 0.027), alcohol intake (beta= 0.479, P < 0.001), and duration of menopause (beta=-1.602, P < 0.001). The results suggest a net decrease in systemic expression of 11beta-HSD1 with increased smoking, BMI, and duration of menopause. Increased systemic expression is seen with increasing age and alcohol intake.
Functional effects of thymopoietin32-36 (TP5) on cytotoxic lymphocyte precursor units (CLP-U). I. Enhancement of splenic CLP-U <i>in vitro</i> and <i>in vivo</i> after suboptimal antigenic stimulation. (1980)

Cytotoxic lymphocyte precursor units (CLP-U) were enumerated in the spleens of C57BL/6 mice 3 days after i.p. injections of synthetic thymopoietin32-36 (TP5). One hundred to 1000 ng TP5/mouse potentiated splenic CLP-U, this effect being detectable only after suboptimal allogeneic sensitization (with 1.2 x 10(5) mitomycin-C treated DBA cells). This elevation of CLP-U persisted in the injected mice for at least 14 days. Control peptide did not affect CLP-U. In vitro incubation of 0.01 to 0.1 ng/ml of TP5 with normal C57BL/6 spleen cells also enhanced CLP-U after suboptimal allogeneic stimulation; high concentrations of TP5 caused suppression of CLP-U and this was detectable with optimal sensitization conditions. Thus TP5, in vitro and in vivo, appears to regulate immune responsiveness and this regulation varies with TP5 dosage and with the immune stimulus.
Effects of the acoustic noise of the gradient systems on fMRI: A study on auditory, motor, and visual cortices (1998)

MR acoustic, or sound, noise due to gradient pulsing has been one of the problems in MRI, both in patient scanning as well as in many areas of psychiatric and neuroscience research, such as brain fMRI. Especially in brain fMRI, sound noise is one of the serious noise sources that obscures the small signals obtainable from the subtle changes occurring in oxygenation status in the cortex and blood capillaries. Therefore, we have studied the effects of acoustic, or sound, noise arising in fMR imaging of the auditory, motor, and visual cortices. The results show that the effects of acoustic noise on motor and visual responses are opposite. That is, for motor activity, there is an increased total motor activation, whereas for visual stimulation, the corresponding (visual) cortical activity is diminished substantially when the subject is exposed to a loud acoustic sound. Although the current observations are preliminary and require more experimental confirmation, it seems that the observed acoustic-noise effects on brain functions, such as in the motor and visual cortices, are new observations and could have significant consequences in data observation and interpretation in future fMRI studies.
Isolation of a murine osteoclast colony-stimulating factor. (1991)

Cultures of a cell line derived from a murine mammary carcinoma that induces hypercalcemia were examined for soluble products that could induce osteoclasts to differentiate from murine bone marrow cells. The serum-free culture supernatant of this cell line stimulated growth of colonies from bone marrow cells that exhibited tartrate-resistant acid phosphatase (TRAPase) activity. These TRAPase-positive cells demonstrated essential features of osteoclasts when cultured with mineralized bone or dentin. The culture period required for colony development and the frequency of colony-forming cells indicated that relatively primitive marrow progenitors were stimulated by a tumor-derived factor(s) to form immature osteoclasts. Other colony-stimulating factors (CSFs), including granulocyte CSF, macrophage CSF, granulocyte-macrophage CSF and interleukin 3, were ruled out as the source of the activity produced by the tumor cells. The biological activity was successfully purified by gel filtration chromatography and reverse-phase HPLC. By SDS/PAGE, the activity was traced to a protein of approximately 17 kDa. Functional and biochemical studies of the purified factor suggest that it is distinct from any known CSF of myeloid cells. This protein appears to be a CSF for the osteoclast lineage, osteoclast CSF (O-CSF).