gebhart/patrepeval huggingface dataset:
Coronin-1 Is Associated with Neutrophil Survival and Is Cleaved during Apoptosis: Potential Implication in Neutrophils from Cystic Fibrosis Patients (2009)

Because neutrophil apoptosis plays a key role in resolving inflammation, identification of proteins regulating neutrophil survival should provide new strategies to modulate inflammation. Using a proteomic approach, coronin-1 was identified as a cytosolic protein cleaved during neutrophil apoptosis. Coronin-1 is an actin-binding protein that can associate with phagosomes and NADPH oxidase, but its involvement in apoptosis was currently unknown. In coronin-1-transfected PLB985 cells, coronin-1 overexpression did not modify the kinetics of granulocyte differentiation as assessed by CD11b labeling. Concerning apoptosis, increased coronin-1 expression in dimethylformamide-differentiated PLB985 significantly decreased gliotoxin-induced mitochondrial depolarization as compared with controls. Likewise, coronin-1 significantly decreased TRAIL-induced apoptosis with less mitochondrial depolarization, caspase-3 and caspase-9 activities, but not caspase-8 or Bid truncation suggesting that coronin-1 interfered with mitochondria-related events. To validate the prosurvival role of coronin-1 in a pathophysiological condition involving neutrophil-dominated inflammation, neutrophils from cystic fibrosis (CF) patients were studied. Circulating neutrophils from CF patients had more coronin-1 expression assessed by immunoblotting or proteomic analysis of cytosolic proteins. This was associated with a lower apoptosis rate than those from controls evidenced by delayed phosphatidylserine externalization and mitochondria depolarization. In addition, inflammatory neutrophils from CF patients lungs showed an intense coronin-1 immunolabeling. We concluded that coronin-1 could constitute a potential target in resolving inflammation.
Reaction Wood: Its Structure and Function (1973)

The mechanism by which the stems of trees recover after being bent or tilted out of the vertical is considered. The mechanical consequences of the tendency for the main stem apex to reerect itself and grow vertically or to be replaced by a vertically growing lateral branch, and of the asymmetrical radial growth of displaced stems, are pointed out. The asymmetry usually develops on the upper side of a bent or tilted hardwood stem and on the under side of a softwood stem. Since such asymmetry can usually be accounted for on the basis of accentuated development of wood rather than bark, the question of the possible functional significance of the wood arises. Experiments are cited to demonstrate that the wood (reaction wood) is effective as a means for assisting displaced stems to recover, contracting longitudinally on the upper side of a hardwood stem and expanding on the under side of a softwood stem. Consideration is then given to the structure, differentiation, and chemical composition of the reaction wood formed by hardwoods and softwoods with a view to locating the force active in aiding recovery and determining its origin. The consequences of associating the support of a still-growing stem displaced from the vertical with the idiosyncracies of secondary wall formation of reaction wood cells, and the reerection of such a stem with lignification of these walls, are explored. On this basis, the hypothesis is advanced that the recovery force is located in the region of differentiating reaction wood cells undergoing lignification, the active force arising from the swelling of cell walls as a result of deposition in them of lignin. Objections to the hypothesis are mentioned.
Apparent diffusion coefficient determination in normal fetal brain: a prenatal MR imaging study. (2003)

Although moderately higher, the ADC determinations we obtained are consistent with those reported in the literature in postnatal studies performed in premature babies.
The violent neutron star (2012)

Neutron stars enable us to study both the highest densities and the highest magnetic fields in the known Universe. In this article I review what can be learned about such fundamental physics using magnetar bursts. Both the instability mechanisms that trigger the bursts, and the subsequent dynamical and radiative response of the star, can be used to explore stellar and magnetospheric structure and composition.
Cyclin-Dependent Kinase 5 (2003)

Since their discovery about 10 years ago, cyclin-dependent kinase 5 (Cdk5) and its activators, p35 and p39, have emerged as important players in both developing and mature brains. Significant advances have been made in Cdk5 research on many fronts in the last few years. This special issue contains a collection of review articles on the current stat
ChemInform Abstract: tert‐Butylpivaloylphosphinous Acid and Its Derivatives. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mechanism for Biotransformation of Nonylphenol Polyethoxylates to Xenoestrogens in <i>Pseudomonas putida</i> (1998)

A strain of Pseudomonas putida isolated from activated sewage grew aerobically on the xenoestrogen precursor, nonylphenol polyethoxylate (NPEOx, where x is the number of ethoxylate units) as sole carbon source. Comparative growth yields on NPEOav6, NPEOav9, and NPEOav20 (mixtures with average ethoxylate numbers as indicated) were consistent with utilization of all but two ethoxylate units, and the final accumulating metabolite was identified by gas chromatography-mass spectroscopy as nonylphenol diethoxylate (NPEO2). There was no growth on nonylphenol or polyethylene glycols, and there was no evidence for production of carboxylic acid analogs of NPEOx. Biodegradation kinetics measured by high-pressure liquid chromatography (HPLC) for each component in NPEOx mixtures showed that biodegradation proceeded via successive exoscission of the ethoxylate chain and not by direct scission between the second and third ethoxylate residues. The NPEOx-degrading activity was inducible by substrate, and cell extracts of NPEOav9-induced cells were also active on the pure alcohol ethoxylate, dodecyl octaethoxylate (AEO8), producing sequentially, under either aerobic or anaerobic conditions, AEO7, AEO6, AEO5, etc., thus demonstrating that the pathway involved removal of single ethoxylate units. HPLC analysis of 2,4-dinitrophenylhydrazone derivatives revealed acetaldehyde (ethanal) as the sole aldehydic product from either NPEOav9 or AEO8 under either aerobic or anaerobic conditions. We propose a mechanism for biotransformation which involves an oxygen-independent hydroxyl shift from the terminal to the penultimate carbon of the terminal ethoxylate unit of NPEOx and dissociation of the resulting hemiacetal to release acetaldehyde and the next-lower homolog, NPEOx-1, which then undergoes further cycles of the same reaction until x = 2.
Underground coal mine monitoring with wireless sensor networks (2009)

Environment monitoring in coal mines is an important application of wireless sensor networks (WSNs) that has commercial potential. We discuss the design of a Structure-Aware Self-Adaptive WSN system, SASA. By regulating the mesh sensor network deployment and formulating a collaborative mechanism based on a regular beacon strategy, SASA is able to rapidly detect structure variations caused by underground collapses. We further develop a sound and robust mechanism for efficiently handling queries under instable circumstances. A prototype is deployed with 27 mica2 motes in a real coal mine. We present our implementation experiences as well as the experimental results. To better evaluate the scalability and reliability of SASA, we also conduct a large-scale trace-driven simulation based on real data collected from the experiments.
Interaction of a GRB-IR Splice Variant (a Human GRB10 Homolog) with the Insulin and Insulin-like Growth Factor I Receptors (1996)

We have utilized the yeast two-hybrid system to identify proteins that interact with the cytoplasmic domain of the insulin receptor. We identified a human cDNA that is a splice variant of the human GRB10 homolog GRB-IR, which we term GRB10/IR-SV1 (for GRB10/GRB-IR splice variant 1). The protein encoded by the GRB10/IR-SV1 cDNA contains an SH2 domain and a pleckstrin homology domain. Cloning of a full-length human cDNA revealed a predicted coding sequence that was similar to the mouse GRB10 protein, although GRB10/IR-SV1 contained an 80-amino acid deletion. The GRB10/IR-SV1 cDNA is a splice variant of the GRB-IR cDNA such that GRB10/IR-SV1 contains an intact pleckstrin homology domain and a distinct amino terminus. The interaction of GRB10/IR-SV1 with the insulin receptor and the insulin-like growth factor I (IGF-I) receptor is mediated by the SH2 domain, and we show that glutathione S-transferase-SH2 domain fusion proteins interact specifically in vitro with the insulin receptor derived from mammalian cells. The GRB10/IR-SV1 SH2 domain also interacted with an approximately 135-kDa phosphoprotein from unstimulated cell lysates, an interaction that decreased after insulin stimulation. We present evidence that the GRB10/IR-SV1 protein plays a functional role in insulin and IGF-I signaling by showing that microinjection of an SH2 domain fusion protein inhibited insulin- and IGF-I-stimulated mitogenesis in fibroblasts, yet had no effect on mitogenesis induced by epidermal growth factor. Our findings suggest that GRB10/IR-SV1 may serve to positively link the insulin and IGF-I receptors to an uncharacterized mitogenic signaling pathway.
Endogenous Peroxisome Proliferator-Activated Receptor-γ Augments Fatty Acid Uptake in Oxidative Muscle (2008)

In the setting of insulin resistance, agonists of peroxisome proliferator-activated receptor (PPAR)-gamma restore insulin action in muscle and promote lipid redistribution. Mice with muscle-specific knockout of PPARgamma (MuPPARgammaKO) develop excess adiposity, despite reduced food intake and normal glucose disposal in muscle. To understand the relation between muscle PPARgamma and lipid accumulation, we studied the fuel energetics of MuPPARgammaKO mice. Compared with controls, MuPPARgammaKO mice exhibited significantly increased ambulatory activity, muscle mitochondrial uncoupling, and respiratory quotient. Fitting with this latter finding, MuPPARgammaKO animals compared with control siblings exhibited a 25% reduction in the uptake of the fatty acid tracer 2-bromo-palmitate (P < 0.05) and a 13% increase in serum nonesterified fatty acids (P = 0.05). These abnormalities were associated with no change in AMP kinase (AMPK) phosphorylation, AMPK activity, or phosphorylation of acetyl-CoA carboxylase in muscle and occurred despite increased expression of fatty acid transport protein 1. Palmitate oxidation was not significantly altered in MuPPARgammaKO mice despite the increased expression of several genes promoting lipid oxidation. These data demonstrate that PPARgamma, even in the absence of exogenous activators, is required for normal rates of fatty acid uptake in oxidative skeletal muscle via mechanisms independent of AMPK and fatty acid transport protein 1. Thus, when PPARgamma activity in muscle is absent or reduced, there will be decreased fatty acid disposal leading to diminished energy utilization and ultimately adiposity.
Relationship between Plasma Parameters and Carbon Atom Coordination in a-C:H Films Prepared by RF Glow Discharge Decomposition (1988)

Amorphous C:H films were prepared by rf glow discharge decomposition from CH 4 using a permanent magnet system to apply a static magnetic field perpendicular to the rf electric field. The structure and properties of a-C:H films have been investigated systematically with respect to the hydrogen content, hardness and coordination of carbon atoms as a function of rf power (self-bias voltage). The coordination of carbon atoms has been determined by solid-state 13 C magic angle spinning nuclear magnetic resonance measurements. It is found that the fraction of graphitic (sp 2 ) versus tetrahedral (sp 3 ) bonding increases with increasing rf power (negative self-bias voltage). Film hardness is understood in terms of the balance between the incorporated hydrogen and the fraction of graphitic (sp 2 ) versus tetrahedral (sp 3 ) bonding. The production of ionic and neutral species from a glow discharge has also been monitored by mass spectroscopy and optical emission spectroscopy to investigate the relation between plasma parameters and carbon atom coordination. Using these measurements and negative self-bias measurements, it is shown that the coordination of carbon atoms is determined not only by the energy of impinging ions on the substrate but also by the type of active species. In addition, the neutral and ionic C 2 H 2 related species are thought to be some of the species which increase the fraction of graphitic (sp 2 ) versus tetrahedral (sp 3 ) bonding.
Scaling of energy absorbing composite plates (1992)

The energy absorption response and crushing characteristics of geometrically scaled graphite-Kevlar epoxy composite plates were investigated. Three different trigger mechanisms including chamfer, notch, and steeple geometries were incorporated into the plate specimens to initiate crushing. Sustained crushing was achieved with a simple test fixture which provided lateral support to prevent global buckling. Values of specific sustained crushing stress (SSCS) were obtained which were comparable to values reported for tube specimens from previously published data. Two sizes of hybrid plates were fabricated; a baseline or model plate, and a full-scale plate with in-plane dimensions scaled by a factor of two. The thickness dimension of the full-scale plates was increased using two different techniques; the ply-level method in which each ply orientation in the baseline laminate stacking sequence is doubled, and the sublaminate technique in which the baseline laminate stacking sequence is repeated as a group. Results indicated that the SSCS is independent of trigger mechanism geometry. However, a reduction in the SSCS of 10-25 percent was observed for the full-scale plates as compared with the baseline specimens, indicating a scaling effect in the crushing response.
Fast cosine transform implementation for television signals (1982)

An algorithm is described for realisation of the discrete cosine transform. The algorithm has been designed to allow implementation in hardware for 625-line pictures. It employs factorisation of the transform matrix into sparse matrices, some of which are sparse factors of a Hadamard matrix. Further attention is given to the sharing of hardware components so as to reduce circuit complexity.
Reactive oxygen species as essential mediators of cell adhesion (2003)

Signal transduction by reactive oxygen species (ROS; "redox signaling") has recently come into focus in cellular biology studies. The signaling properties of ROS are largely due to the reversible oxidation of redox-sensitive target proteins, and especially of protein tyrosine phosphatases, whose activity is dependent on the redox state of a low pKa active site cysteine. A variety of mitogenic signals, including those released by receptor tyrosine kinase (RTKs) ligands and oncogenic H-Ras, involve as a critical downstream event the intracellular generation of ROS. Signaling by integrins is also essential for the growth of most cell types and is constantly integrated with growth factor signaling. We provide here evidence that intracellular ROS are generated after integrin engagement and that these oxidant intermediates are necessary for integrin signaling during fibroblast adhesion and spreading. Moreover, we propose a synergistic action of integrins and RTKs for redox signaling. Integrin-induced ROS are required to oxidize/inhibit the low molecular weight phosphotyrosine phosphatase, thereby preventing the enzyme from dephosphorylating and inactivating FAK. Accordingly, FAK phosphorylation and other downstream events, including MAPK phosphorylation, Src phosphorylation, focal adhesion formation, and cell spreading, are all significantly attenuated by inhibition of redox signaling. Hence, we have outlined a redox circuitry whereby, upon cell adhesion, oxidative inhibition of a protein tyrosine phosphatase promotes the phosphorylation/activation and the downstream signaling of FAK and, as a final event, cell adhesion and spreading onto fibronectin.
Combining Local and Global Image Features for Object Class Recognition (2006)

Object recognition is a central problem in computer vision research. Most object recognition systems have taken one of two approaches, using either global or local features exclusively. This may be in part due to the difficulty of combining a single global feature vector with a set of local features in a suitable manner. In this paper, we show that combining local and global features is beneficial in an application where rough segmentations of objects are available. We present a method for classification with local features using non-parametric density estimation. Subsequently, we present two methods for combining local and global features. The first uses a "stacking" ensemble technique, and the second uses a hierarchical classification system. Results show the superior performance of these combined methods over the component classifiers, with a reduction of over 20% in the error rate on a challenging marine science application.
Accurate and efficient determination of the shoreline in ERS-1 SAR images (1996)

Extraction of the shoreline in SAR images is a difficult task to perform using simple image processing operations such as grey-value thresholding, due to the presence of speckle and because the signal returned from the sea surface may be similar to that from the land. A semiautomatic method for detecting the shoreline accurately and efficiently in ERS-1 SAR images is presented. This is aimed primarily at a particular application, namely the construction of a digital elevation model of an intertidal zone using SAR images and hydrodynamic model output, but could be carried over to other applications. A coarse-fine resolution processing approach is employed, in which sea regions are first detected as regions of low edge density in a low resolution image, then image areas near the shoreline are subjected to more elaborate processing at high resolution using an active contour model. Over 90% of the shoreline detected by the automatic delineation process appear visually correct.
Magnetically confined plasma reactive ion etching of GaAs/AlGaAs/AlAs quantum nanostructures (1994)

An electron cyclotron resonance reactive ion etching machine has been successfully run under low magnetic field conditions. We call this the magnetically confined plasma condition. Under this condition, a new process using SiCl4 with a small amount of O2 has been developed for etching nanometer scale structures on GaAs, AlGaAs, and AlAs multilayer materials. The effects of the percentage of O2, the rf power, the microwave power, and the flow rate are described. 100 nm quantum dots have been etched on multiple quantum well materials to a depth of about 1 μm. Vertical and smooth sidewalls were obtained on these nanostructures. Poly-methylmethacrylate (PMMA) electron beam resist can be used directly as a dry etch mask, and the selectivity between GaAs and PMMA can be as high as 28:1. Raman spectroscopic studies showed that the process induced no detectable damage to the surface for an etch depth of 130 nm and only very little damage for deeper etching.
Advances in solar heating and cooling systems (1976)

A brief review is given of a number of proposed methods of collecting, storing, and utilizing solar energy. (AIP)
[State of the art of the problem concerning endovascular treatment of abdominal aortic aneurysms of infrarenal localization]. (2018)

The problem concerning diagnosis and treatment of abdominal aortic aneurysms (AAA) is important today because of a high proportion of this pathology within the structure of population morbidity and mortality, with a tendency of these indices to increase, as well as high lethality rates in development of complications. Endovascular treatment of aortic aneurysms is one of the most rapidly developing methods of treatment in vascular surgery. Over the last two decades this type of treatment has been playing an important part in the armamentarium of the vascular surgeon and is often considered as primary treatment of patients with AAA of infrarenal localization. Nevertheless, long-term efficacy and reliability of this method have been argued. These argues are based on the fact that according to the findings of various studies the advantages of endovascular treatment of aneurysms over open surgical treatment are completely leveled after 6-8 years. The main disadvantage of endovascular treatment is the necessity of repeat interventions in the long-term period of follow-up. However, in a series of studies repeat interventions in groups of both surgical and endovascular treatment were either not taken into account or not specially studied. It should also be taken into consideration that first European studies were carried out with the use of grafts of first generations, and some of them are not used any more. Therefore, the necessity of carrying out further studies still remains. Perhaps, new generations will be able to decrease the frequency of repeat interventions and thereby improve the overall results of endovascular treatment. The possibilities of endovascular treatment of AAAs will constantly be extended, including due to the development of X-ray equipment and software, as well as at the expense of various auxiliary technologies.
Performance models for ATM switching of mixed continuous-bit-rate and bursty traffic with threshold-based discarding (2003)

An exact performance analysis of an asynchronous transfer mode (ATM) statistical multiplexer whose inputs consist of superposition of mixed continuous-bit-rate and bursty traffic is presented. Two priority levels are considered for each class of traffic. ATM cells arriving at the multiplexer are generated according to a Markov modulated Poisson process. The performance of the multiplexer for different classes of traffic was investigated. The quality of service required for each class is met by introducing selective cell discarding using a partial buffer sharing scheme. The performance of the multiplexer for both deterministic and exponential service distributions was investigated. The results indicate that the deterministic service compared to the exponential service shows better performance in the same traffic environment. It is shown that for heavy load situations the exponential service requires less buffer space than the deterministic service. It is also shown that the loss probability obtained under the deterministic service is about one order of magnitude lower than that of the exponential service.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Influencing Parameters and Error Sources During Indication on Internal Combustion Engines (1992)

<div class="htmlview paragraph">The smaller the potential for improvement of the internal combustion engine becomes, the higher is the need for the precise indication of the cylinder pressure. Through optimum selection and maintenance of the instruments, measuring errors can be kept to a minimum. However, the skilled engineer must still be able to interpret accurately results, too, that may not be 100 % correct.</div> <div class="htmlview paragraph">The influencing parameters and error sources gained from experience as well as their individual consequences are discussed in this paper with the object of avoiding errors and interpreting unavoidable errors correctly.</div>