gebhart/patrepeval huggingface dataset:
Agent-based homeostatic control for green energy in the smart grid (2011)

With dwindling nonrenewable energy reserves and the adverse effects of climate change, the development of the smart electricity grid is seen as key to solving global energy security issues and to reducing carbon emissions. In this respect, there is a growing need to integrate renewable (or green) energy sources in the grid. However, the intermittency of these energy sources requires that demand must also be made more responsive to changes in supply, and a number of smart grid technologies are being developed, such as high-capacity batteries and smart meters for the home, to enable consumers to be more responsive to conditions on the grid in real time. Traditional solutions based on these technologies, however, tend to ignore the fact that individual consumers will behave in such a way that best satisfies their own preferences to use or store energy (as opposed to that of the supplier or the grid operator). Hence, in practice, it is unclear how these solutions will cope with large numbers of consumers using their devices in this way. Against this background, in this article, we develop novel control mechanisms based on the use of autonomous agents to better incorporate consumer preferences in managing demand. These agents, residing on consumers' smart meters, can both communicate with the grid and optimize their owner's energy consumption to satisfy their preferences. More specifically, we provide a novel control mechanism that models and controls a system comprising of a green energy supplier operating within the grid and a number of individual homes (each possibly owning a storage device). This control mechanism is based on the concept of homeostasis whereby control signals are sent to individual components of a system, based on their continuous feedback, in order to change their state so that the system may reach a stable equilibrium. Thus, we define a new carbon-based pricing mechanism for this green energy supplier that takes advantage of carbon-intensity signals available on the Internet in order to provide real-time pricing. The pricing scheme is designed in such a way that it can be readily implemented using existing communication technologies and is easily understandable by consumers. Building upon this, we develop new control signals that the supplier can use to incentivize agents to shift demand (using their storage device) to times when green energy is available. Moreover, we show how these signals can be adapted according to changes in supply and to various degrees of penetration of storage in the system. We empirically evaluate our system and show that, when all homes are equipped with storage devices, the supplier can significantly reduce its reliance on other carbon-emitting power sources to cater for its own shortfalls. By so doing, the supplier reduces the carbon emission of the system by up to 25% while the consumer reduces its costs by up to 14.5%. Finally, we demonstrate that our homeostatic control mechanism is not sensitive to small prediction errors and the supplier is incentivized to accurately predict its green production to minimize costs.
Wärme (1948)

ZusammenfassungEin mit zerstoßenem Eis gefülltes Gefäß werde über die Flamme eines Spiritus- oder Gasbrenners gestellt. Bringen wir den Finger in die Nähe des Eises oder berühren wir es, so haben wir die Empfindung der Kälte, bei Annäherung an die Flamme die der Hitze. — Allmählich schmilzt das Eis, später verdampft das Wasser; dazwischen sind Gefäß und Wasser der Reihe nach kalt, kühl, Iau, warm, heiß.
Small fission power systems for Mars (2002)

A Mars surface power system configuration with an output power of 3 kWe and a system mass of 775 kg is described. It consists of a heatpipe-cooled reactor with UN fuel coupled to a Stirling engine with a fixed conical radiator driven by loop heat pipes. Key to achieving this low mass is the use of a highly radiation-resistant multiplexer for monitoring and controlling the reactor, as well as radiation resistant generators and motors. Also key is the judicious placement of shields to prevent radiation scattered from the Martian surface and air from damaging the reactor controls. Several alternate configurations also are briefly looked at, including a moderated reactor with UZrH fuel and a reactor using 233U instead of 235U. The moderated reactor system has essentially the same mass as the baseline unmoderated UN system and yields the same radiation shielding requirements. The 233U reactor is significantly smaller and yields a system mass about 228 kg lighter than with 235U, but part of this weight reduction is due to the use of removable neutron absorbers to assure subcriticality with water immersion, as opposed to permanently placed absorbers.
Interpolation of Linear Prediction Coefficients for Speech Coding (2000)

Speech coding algorithms have different dimensions of performance. Among them, speech quality and average bit rate are the most important performance aspects. The purpose of the research is to improve the speech quality within the constraint of a low bit rate. Most of the low bit rate speech coders employ linear predictive coding (LPC) that models the short-term spectral information as an all-pole filter. The filter coefficients are called linear predictive (LP) coefficients. The LP coefficients are obtained from standard linear prediction analysis, based on blocks of input samples. In transition segments, a large variation in energy and spectral characteristics can occur in a short time interval. Therefore, there will be a large change in the LP coefficients in consecutive blocks. Abrupt changes in the LP parameters in adjacent blocks can introduce clicks in the reconstructed speech. Interpolation of the filter coefficients results in a smooth variation of the interpolated coefficients as a function of time. Thus, the interpolation of the LP coefficients in the adjacent blocks provides improved quality of the synthetic speech without using additional information for transmission.
Expression silence of DNA repair gene hMGMT induced by RNA interference (2007)

MGMT protein expression has been associated with tumor resistance to alkylating agents. The objective of this paper is to construct the RNA interference vector which can specifically induce the expression silence of human DNA repair gene hMGMT. The hMGMT specific siRNA expression cassette was made by two steps PCR, linked with pUC19 to get pU6-MGMTi, co-transfected with pEGFP-C1 into 16HBE and screened by G418. The MGMT mRNA and protein levels were detected by RT-PCR and Western Blot respectively. hMGMT specific RNA interfere vector pU6-MGMTi was constructed successfully. In transfected 16HBE cells MGMT mRNA level could hardly be detected and the protein level was only 10% of control. MGMT specific RNAi expression cassette can effectively inhibit MGMT expression. MGMT silence cell line was built by co-transfection technology, which offered condition for studying the gene function of MGMT.
Effect of Adlayer Structure on the Host−Guest Recognition between Calcium and Crown-Ether-Substituted Phthalocyanine Arrays on Au Single-Crystal Surfaces (2004)

Adlayers of 15-crown-5-ether-substituted cobalt(II) phthalocyanine (CoCRPc) were prepared by immersion of either Au(111) or Au(100) substrate into benzene-ethanol (9:1 v/v) mixed solutions containing CoCRPc. In situ STM imaging was carried out after transferring the CoCRPc-modified Au crystals into aqueous HClO(4) solution. The packing arrangement of the CoCRPc array on Au(111) was determined to be p(8 x 4 radical 3R - 30 degrees ), and the internal structure was clearly observed by high-resolution STM. Two adlayer structures of CoCRPc, (8 x 9) and (4 radical 5 x 4 radical 5)R26.7 degrees, were found on the Au(100)-(1 x 1) terrace. In the presence of 1 mM Ca(2+), two Ca(2+) ions were trapped in two diagonally located 15-crown-5-ether moieties of each CoCRPc molecule on Au(111), whereas encapsulation of Ca(2+) ions was not seen in the CoCRPc arrays on the Au(100)-(1 x 1) surface. The present study demonstrates that the relationship between crown moieties of CRPc and the underlying Au lattice is important in the trapping of Ca(2+) ions in crown rings.
Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline (2011)

Midlife hypertension, diabetes, smoking, and obesity were associated with an increased rate of progression of vascular brain injury, global and hippocampal atrophy, and decline in executive function a decade later.
Relationships Among TCR Ligand Potency, Thresholds for Effector Function Elicitation, and the Quality of Early Signaling Events in Human T Cells (1998)

Determining how receptor ligand quality and quantity together control the biologic responses of T cells is central to understanding normal and pathologic T cell immunity. Here we have carefully examined how variations in antigenic peptide structure and dose affect multiple functional responses of human T cell clones and have correlated these observations with proximal TCR signaling events induced by the same set of related ligands. As the Ag concentration increases, effector functions are elicited according to a clone-specific hierarchy. The absolute amount of each peptide required to stimulate the entire set of effector functions (potency) differs markedly among ligands for a single TCR, correlating with the efficiency of TCR down-modulation and the extent of ZAP-70 activation. However, distinct patterns of TCR zeta-chain phosphorylation were observed, with the ratios of TCRzeta isoforms relating to ligand agonist potency. The appearance of partially phosphorylated TCRzeta isoforms was paralleled by relative changes in certain response thresholds within the hierarchy. Thus, a combination of density, potency, and quality of signaling all contribute to the distinct effects of agonist ligands on T cell immunity.
Click fraud botnet detection by calculating mix adjusted traffic value: A method for de-cloaking click fraud attacks that is resistant to spoofing (2013)

Click Fraud remains one of the most durable fraudulent schemes online. With 50 billion dollars being generated per year by Google alone, a fraudulent publisher is able to capture a significant amount of revenue with a small investment. The most well heeled click fraud attacks employ large distributed botnets, deceptive publisher pages, malware infection, and fake conversion “chaff” in an attempt to cloak fraudulent activity. We describe an algorithm that we call Mix Adjustment which corrects for traffic bias differences. The method is scalable and we show a simple implementation that can be applied to current weblog processing systems. We show two case studies of this algorithm on real fraud detection problems: (a) WOW Bot net detection, (b) Advertiser fraud detection.
Rho Kinase Acts as a Downstream Molecule to Participate in Protein Kinase Cε Regulation of Vascular Reactivity After Hemorrhagic Shock in Rats (2014)

Our previous study demonstrated that Rho kinase and protein kinase C (PKC) played important parts in the regulation of vascular reactivity after shock. Using superior mesenteric arteries (SMAs) from hemorrhagic shock rats and hypoxia-treated vascular smooth muscle cells (VSMCs), relationship of PKCε regulation of vascular reactivity to Rho kinase, as well as the signal transduction after shock, was investigated. The results showed that inhibition of Rho kinase with the Rho kinase-specific inhibitor Y-27632 antagonized the PKCε-specific agonist carbachol and highly expressed PKCε-induced increase of vascular reactivity in SMAs and VSMCs, whereas inhibition of PKCε with its specific inhibitory peptide did not antagonize the Rho kinase agonist (U-46619)-induced increase of vascular reactivity in SMAs and VSMCs. Activation of PKCε or highly expressed PKCε upregulated the activity of Rho kinase and the phosphorylation of PKC-dependent phosphatase inhibitor 17 (CPI-17), zipper interacting protein kinase (ZIPK), and integrin-linked kinase (ILK), whereas activation of Rho kinase increased only CPI-17 phosphorylation. The specific neutralization antibodies of ZIPK and ILK antagonized PKCε-induced increases in the activity of Rho kinase, but CPI-17 neutralization antibody did not antagonize this effect. These results suggested that Rho kinase takes part in the regulation of PKCε on vascular reactivity after shock. Rho kinase is downstream of PKCε. Protein kinase Cε activates Rho kinase via ZIPK and ILK; CPI-17 is downstream of Rho kinase.
Bile Acids and Farnesoid X Receptor: Novel Target for the Treatment of Diabetic Cardiomyopathy (2019)

Diabetes mellitus (DM) has become an increasingly common disease with high disability and mortality rates. Diabetes complications are the main cause of diabetes death and about 50% of diabetic patients died from heart disease in developed countries reported by World Health Organization. Diabetic cardiomyopathy (DCM) has been considered as a high incidence and serious complication of DM and plays a key role in the incidence and development of diabetes related heart failure. Metabolism dysregulation is regarded as an important and earlier factor occurred in the pathogenesis of DCM. Insulin resistance, oxidative stress, inflammation and mitochondrial dysfunction also contribute to the development of DCM. Farnesoid X Receptor (FXR) is a member of nuclear receptor superfamily, and plays a critical role in regulating lipid and glucose metabolism, oxidative stress and inflammation. FXR is activated by primary bile acids (BAs) such as chenodeoxycholic acid, cholic acid and synthetic agonists such as obeticholic acid. BAs are the main active ingredients of many natural products and traditional medicines, especially bile or gallstones in animals, such as calculus bovis. Due to the regulatory effect of FXR on glucose and lipid metabolism, oxidative stress and inflammation, the treatment of BAs and FXR agonists for metabolic syndrome and DCM have gained more attention. This review will focus on the pathogenesis of diabetic cardiomyopathy and the regulatory effect of BAs and FXR on DCM.
One-Sample Multiple Testing Procedure for Phase II Clinical Trials (1982)

Commonly, the central objective of Phase II clinical trials is the assessment of the antitumor 'therapeutic efficacy' of a specific treatment regimen. It is of interest to formulate test procedures which can be employed in these trials to decide whether or not this therapeutic efficacy warrants further investigation. For ethical reasons, these procedures should allow for early termination if initial results are extreme. In this paper, a one-sample multiple testing procedure is proposed which employs the standard single-stage test procedure at the last test, and which both allows for early termination and essentially preserves the size, power and simplicity of the single-stage procedure.
Hypermedia and the Teaching of Computer Science: Evaluating an Open System (1992)

: The authors have been involved in a project to build an open hypermedia system known as Microcosm. This paper examines the reasons why hypermedia has made so little impact on teaching in higher education. The open hypermedia system, Microcosm is introduced, and an experiment to use the system to support the teaching of SML as a first language is described. 1 The Development of the Use of Hypermedia in Education Hypermedia has for some time been proposed as an adjunct to printed material within the educational process. However, large scale implementation of such material in any educational setting has yet to materialise, which implies that there are still barriers to the extensive use of hypermedia in education. These may be summarised as follows: 1.1 Authoring is non-trivial Typically academic staff are already heavily burdened with administrative duties, and although many may initially be enthusiastic about using hypermedia, it is only realistic to recognise that they may be deter...
Atomic Control of Conductivity Versus Ferromagnetism in Wide-Gap Oxides Via Selective Doping: V, Nb, Ta in Anatase<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mi>TiO</mml:mi><mml:mn>2</mml:mn></mml:msub></mml:math> (2008)

We identify two general types of electronic behaviors for transition-metal impurities that introduce excess electrons in oxides. (i) The dopants introduce resonant states inside the host conduction band and produce free electrons; (ii) the dopants introduce a deep gap state that carries a magnetic moment. By combining electronic structure calculations, thermodynamic simulations, and percolation theory, we quantify these behaviors for the case of column V-B dopants in anatase TiO2. Showing behavior (i), Nb and Ta dopants can convert the insulator TiO2 into a transparent conductor. Showing behavior (ii), V dopants could convert nonmagnetic TiO2 into a ferromagnet. Whether a dopant shows behavior (i) or (ii) is encoded in its atomic d orbital energy.
Duration of oestrus and time of ovulation in mares treated with synthetic Gn-RH (AY-24,031). (1975)

Synthetic Gn-RH, administered during oestrus, stimulates the release of pituitary LH in the cyclic mare. Duration of oestrus was significantly reduced by 1 mg Gn-RH given on Day 2 of oestrus; the time of ovulation, measured in days from the onset of oestrus, also tended to be reduced. An injection of 2 mg Gn-RH had nor further effect, but daily injections from Day 2 until ovulation significantly shortened the duration of oestrus and the time to ovulation. The profiles of LH were found to be variable from mare to mare, but in all mares, treated and control, elevation of LH was detected close to the time of ovulation.
Diffusion model of photoaligning in azo-dye layers (2004)

The model of the rotational diffusion of the azo-dye molecules under the action of polarized uv light was used to explain the formation of the photoinduced order in azo-dye layers. We consider both the approximations of negligible and strong molecular interaction during the process of the reorientation under the field of a polarized light. We constructed an experimental setup, based on a photoelastic modulator, that allows accurate in situ measurements of the phase retardation delta of thin film as a function of the exposure time t(exp) and exposure power W (W/ cm(2) ). A good agreement with experiment was observed. Fitting the experimental curves delta ( t(exp) ) for different power values W, we can estimate the coefficient of rotational diffusion D, azo-dye order parameter S ( t(exp) ), and other parameters of the rotational diffusion model.
Incremental Learning of NCM Forests for Large-Scale Image Classification (2014)

In recent years, large image data sets such as "ImageNet", "TinyImages" or ever-growing social networks like "Flickr" have emerged, posing new challenges to image classification that were not apparent in smaller image sets. In particular, the efficient handling of dynamically growing data sets, where not only the amount of training images, but also the number of classes increases over time, is a relatively unexplored problem. To remedy this, we introduce Nearest Class Mean Forests (NCMF), a variant of Random Forests where the decision nodes are based on nearest class mean (NCM) classification. NCMFs not only outperform conventional random forests, but are also well suited for integrating new classes. To this end, we propose and compare several approaches to incorporate data from new classes, so as to seamlessly extend the previously trained forest instead of re-training them from scratch. In our experiments, we show that NCMFs trained on small data sets with 10 classes can be extended to large data sets with 1000 classes without significant loss of accuracy compared to training from scratch on the full data.
The Antishock Pelvic Clamp (1991)

Unstable posterior pelvic ring disruptions are frequently accompanied by severe venous bleeding and hypotension. Mechanical stabilization has been shown to help reduce such blood loss. A new external fixator called an antishock clamp provides direct reduction and compression of such fracture-diastases about the sacroiliac joint. It is used acutely to rapidly stabilize the posterior pelvic ring in hypotensive patients. The simplicity of design allows the device to be applied in less than ten minutes in the emergency room. Most importantly, it does not interfere with the ability to carry out subsequent laparotomy or other required procedures. Although more clinical experience is needed, the clamp has provided hemodynamic stabilization accompanying fracture reduction. The device is not expected to be of benefit in the cases with significant bleeding of arterial origin.
Aging-Dependent Alterations in Synaptic Plasticity and Memory in Mice That Overexpress Extracellular Superoxide Dismutase (2006)

Oxidative damage caused by reactive oxygen species (ROS) has been proposed to be critically involved in several pathological manifestations of aging, including cognitive dysfunction. ROS, including superoxide, are generally considered as neurotoxic molecules whose effects can be alleviated by antioxidant enzymes. However, ROS also are known to be necessary components of the signal transduction cascades underlying normal synaptic plasticity. Therefore, we reasoned that the role that ROS and antioxidant enzymes play in modulating neuronal processes varies over the lifespan of an animal. We examined hippocampal long-term potentiation (LTP) and memory-related behavioral performance in transgenic mice overexpressing extracellular superoxide dismutase (EC-SOD) and their wild-type littermates at different ages. We found that aged EC-SOD transgenic mice exhibited enhanced hippocampal LTP, better cerebellum-dependent motor learning, and better hippocampus-dependent spatial learning compared with their wild-type littermates. We also found that EC-SOD overexpression impaired contextual learning, but the impairment was decreased in the aged transgenic mice. At the molecular level, aged EC-SOD transgenic mice had lower superoxide levels, a decrease in protein carbonyl levels, and a decrease in p38 and extracellular signal-regulated kinase 2 phosphorylation compared with aged wild-type mice. Our findings suggest that elevated levels of superoxide contribute to aging-related impairments in hippocampal LTP and memory, and that these impairments can be alleviated by overexpression of EC-SOD. We conclude that there is an age-dependent alteration in the role of superoxide in modulating synaptic plasticity and learning and memory.
Precision Oncology: Who, How, What, When, and When Not? (2017)

Precision oncology, defined as molecular profiling of tumors to identify targetable alterations, is rapidly developing and has entered the mainstream of clinical practice. Genomic testing involves many stakeholders working in a coordinated fashion to deliver high-quality tissue samples to high-quality laboratories, where appropriate next-generation sequencing (NGS) molecular analysis leads to actionable results. Clinicians should be familiar with the types of genomic variants reported by the laboratory and the technology used to determine the results, including limitations of current testing methodologies and reports. Interpretation of genomic results is best undertaken with multidisciplinary input to reduce uncertainty in clinical recommendations relating to a documented variant. Non–small cell lung cancer has emerged as a prototype disease where genomic data from at least several well-documented alterations with approved targeted agents are essential for optimal treatment from diagnosis of advanced disease. Due to the development of resistance to targeted therapies, resampling and retesting of tumors, including using liquid biopsy technology after clinical progression, may be important in making treatment decisions. The value of molecular profiling depends on avoiding both underutilization for well-documented variant target-drug pairs and overutilization of variant-drug therapy without proven benefit. As techniques evolve and become more cost effective, the use of molecular testing may prove to add more specificity and improve outcomes for a larger number of patients.