gebhart/patrepeval huggingface dataset:
A simulation model to improve warehouse operations (2007)

Warehouse or distribution centre managers have to decide how to collect the products to fulfill customers requests but also where to locate the products (SKUs) and how much space to allocate to each of them. Moreover, they have to deploy replenishment strategies to guarantee the reliability of their own stocks. These are challenging decisions because of their level of complexity and their high impact on the centre performance in terms of both its throughput and the operation costs. In particular, the goal of this work is to evaluate whether specific strategies to share the storage space could lead to reduce the operation costs while keeping the service level as high as possible. To this end, this paper develops a discrete event simulation model of the logistic operations at a real high throughput warehouse which handles more than 12 millions of cases annually. Preliminary results show that potential economies may be achieved by reducing the number of stock-outs at the picking area where customer orders are collected.
A modular software process mini-assessment method (2000)

The article describes one approach for dealing with a common problem in software process assessment: some organizations want feedback on their processes, but they cannot devote three arduous weeks to an "official" CMM assessment. In the mini-assessment method presented, individual assessment components are selected to focus the investigation on specific concerns and to scope the effort to a level appropriate to the organization.
In-Line Waveguide Selective Linear Phase Filters (1974)

A procedure is described whereby narrow-band waveguide selective linear phase filters may be designed from a low-pass prototype linear phase network. The structure is comprised of a cascade connection of basic sections, each containing a direct-coupled cavity together with a dual-mode resonator. Each dual-mode resonator takes the form of a square guide mounted on the broad wall of the main rectangular guide and coupled to this guide by a small aperture. Explicit formulas for the susceptance of the coupling apertures and electrical lengths of the cavities are given in terms of the low-pass prototype.
Nosocomial Transmission of Multidrug-resistant <i>Mycobacterium tuberculosis</i> (1992)

These data suggest nosocomial transmission of multidrug-resistant tuberculosis occurred from patient to patient and from patient to health care worker and underscore the need for effective acid-fast bacilli isolation facilities and adherence to published infection control guidelines in health care institutions.
Applications of magnetic circular dichroism: a Hammett-like equation for structural work. Determination of protonation sites in azaindolizines (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplications of magnetic circular dichroism: a Hammett-like equation for structural work. Determination of protonation sites in azaindolizinesJohn W. Downing, Jacek W. Waluk, Branko Stanovnik, and Josef MichlCite this: J. Org. Chem. 1985, 50, 3, 302–311Publication Date (Print):February 1, 1985Publication History Published online1 May 2002Published inissue 1 February 1985https://pubs.acs.org/doi/10.1021/jo00203a004https://doi.org/10.1021/jo00203a004research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A microwave vector voltmeter system (1976)

This report presents a system description and operating procedure for a vector voltmeter system which covers the frequency range .5 to 12 GHz. The design is based upon a seven-port junction where phase and amplitude informa- tion is obtained using only power detectors. The system is computer controlled and self -calibrating for ratio measurements .
Lung Cell Oxidant Injury (1982)

The oxidant damage of lung tissue during in vivo hyperoxic exposure appears to be amplified by neutrophils that release toxic amounts of oxygen metabolites. In our studies cloned lung epithelial cells (L2 cells), lung fibroblasts, and pulmonary artery endothelial cells were cultured under either ambient (Po(2) approximately 140 torr) or hyperoxic (Po(2) approximately 630 torr) conditions for 48 h (24 h for endothelial cells). After cultivation, phorbol myristate acetate- or opsonized zymosan-stimulated neutrophils were added to the cultivated monolayers for 4 h, and lung cell damage was quantitated using (51)Cr release as an index. The data show that stimulated neutrophils are able to injure the three lung cell lines tested, with endothelial cells being highly susceptible to this injury and L2 cells being slightly more susceptible than lung fibroblasts. The studies also demonstrate that all three lung cell lines exposed to sustained hyperoxia are more susceptible to neutrophil-mediated cytotoxicity than their time-matched air controls. Hydrogen peroxide was the main toxic oxygen metabolite because catalase (2,500 U/ml) completely protected the target cells. Equivalent quantities of hydrogen peroxide generated by glucose oxidase instead of by neutrophils gave a similar degree of target cell injury. Superoxide dismutase at high concentrations (250 mug/ml) provided some protection. Other systems that detoxify oxygen metabolites were without protective effect. These findings indicate that the increase in susceptibility of lung cells to neutrophil-mediated oxidant damage is a toxic effect of hyperoxia on lung cells. This specific manifestation of oxygen damage provides insight into the integration between primary mechanisms (oxygen exposure) and secondary mechanisms (release of oxygen metabolites by neutrophils) with respect to the cellular basis for pulmonary oxygen toxicity.
Detecting Unauthorized Modification of HTTP Communication with Steganography (2010)

HTTP does not secure its requests and responses. Using Man-in-the-Middle attack, it is possible to alter the HTTP communication, while it still would look authentic. This can be a problem, if you download data such as PGP key, TOR client, access banking services on-line, or when there is an interest to filter what you can read on the Internet. It should be noted that under particular circumstances, it is possible to attack HTTPS secured communication successfully. This paper proposes a steganography scheme that can be used to detect unauthorized modifications of HTTP communication.
Searching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function (2009)

The pairing of selection and screening methods with randomly mutated libraries can be an exceptionally powerful means for probing the functions of biological molecules and for developing novel regents from random libraries of peptides and oligonucleotides. The use of such approaches is beginning to permeate the ion channel field where they are being deployed to uncover fundamental aspects about ion channel structure and gating, small molecule-channel interactions, and the development of novel agents to control channel activity.
c‐Src/Lyn kinases activate <i>Helicobacter pylori</i> CagA through tyrosine phosphorylation of the EPIYA motifs (2002)

The human pathogen Helicobacter pylori colonizes the mucous layer of the stomach. During parasitic infection, freely swimming bacteria adhere to the gastric epithelial cells and trigger intracellular signalling pathways. This process requires the translocation of the effector protein CagA into the host cell through a specialized type IV secretion system encoded in the cag pathogenicity island. Following transfer, CagA is phosphorylated on tyrosine residues by a host cell kinase. Here, we describe how the tyrosine phosphorylation of CagA is restricted to a previously identified repeated sequence called D1. This sequence is located in the C-terminal half of the protein and contains the five-amino-acid motif EPIYA, which is amplified by duplications in a large fraction of clinical isolates. Tyrosine phosphorylation of CagA is essential for the activation process that leads to dramatic changes in the morphology of cells growing in culture. In addition, we observed that two members of the src kinases family, c-Src and Lyn, account for most of the CagA-specific kinase activity in host cell lysates. Thus, CagA translocation followed by tyrosine phosphorylation at the EPIYA motifs promotes a growth factor-like response with intense cytoskeletal rearrangements, cell elongation effects and increased cellular motility.
Marshall Misconstrued: Activist? Partisan? Reactionary?, 33 J. Marshall L. Rev. 1109 (2000) (2000)

It is a distinct privilege to conclude the symposium of the John Marshall Law School on the Life and Jurisprudence of Chief Justice John Marshall.The papers presented ranged widely over Marshall's judicial career, and illustrate the unparalleled contribution of the great Chief Justice to American jurisprudence.Perhaps, in that context, I might remind you of some of the characteristics Marshall brought to the bench when he was appointed Chief Justice of the United States in 1801.Namely:" A total lack of judicial experience; " A widely circulated reputation for indolence; and, * An unquenchable thirst for Madeira.Of course, he also brought to the Court what Senator Rufus King of New York called "the best organized mind of his generation."'He had experience at the highest levels of both the executive and legislative branches of government, serving as Secretary of State at the time of his appointment, and before that as the floor leader of the Adams Federalists in the House of Representatives.He had already carved out a career as the most successful appellate lawyer in Virginia -then the most populous state in the Union-frequently working in tandem with Patrick Henry in some of the most important cases of the era.He was the personal attorney of George Washington and George Mason, and served as the principal lawyer for most Virginians (including Thomas Jefferson) in the British debt cases of the early 1790s.He had distinguished himself in a trying diplomatic mission to Paris, besting French foreign minister Talleyrand in the famous XYZ affair, thereby setting the stage for the Convention of Mortefontaine, terminating the naval war with France, and
Comparison of the efficiency of combined extracorporeal shock-wave therapy and triple therapy versus triple therapy itself in Category III B chronic pelvic pain syndrome (CPPS) (2016)

The aim of this study is to determine the effect of combining extracorporeal shock-wave therapy (ESWT) and triple therapy versus triple therapy alone, when treating Category III B chronic prostatitis (CPPS). Study included 60 patients, classified as having CPPS, divided into two groups: the first group numbered 30 patients, who were treated with a combination of an α-blocker, an anti-inflammatory agent and a muscle relaxant; the second group consisted of 30 patients who received a combination of ESWT and the fore-mentioned triple therapy. Patients were treated for 12 weeks. The primary criterion of a response to therapy was scoring 2 or less on the NIH-CPSI quality of life item, while the secondary criterion of a response to therapy was a greater than a 50% reduction in NIH-CPSI pain score. Patients who received triple therapy did not show a significant change neither in post void residual urine (PVR) nor in maximum flow rate (Q<sub>MAX</sub>), while the second group of patients exhibited significant improvement in both PVR and Q<sub>MAX</sub> values. Both groups of patients showed statistically significant improvement in all items of the NIH-CPSI score after the treatment, with significantly better results in the second group.
Carbon Nanotube-Polyamidoamine Dendrimer Hybrid-Modified Electrodes for Highly Sensitive Electrochemical Detection of MicroRNA24 (2015)

A simple and ultrasensitive microRNA (miRNA) electrochemical biosensor employing multiwalled carbon nanotube (MWCNT)-polyamidoamine (PAMAM) dendrimer and methylene blue (MB) redox indicator is reported in this work. The assay utilizes a glass carbon (GC) electrode modified with MWCNT-PAMAM, on which the oligonucleotide capture probes are immobilized. The electrochemical detection of miRNAs is completed by measuring the reduction signal change of MB before and after the probe hybridization with target miRNA (miRNA24 is used as a model case). The MWCNT-PAMAM/GC electrode shows greatly enhanced signal to MB reduction in contrast to bare GC electrode. The functionalization of MWCNT with PAMAM maintains the electrochemical property of MWCNT to MB reduction but minimizes the undesired adsorption of MB on the MWCNT surface. The effect of experimental variables on the miRNA detection is investigated and optimized. A detection limit of 0.5 fM and a linear peak current density-concentration relationship up to 100 nM are obtained following 60 min hybridization. The proposed assay is successfully used to detect miRNA24 in total RNA sample extracted from HeLa cells.
Complications of Pediatric Femur Fractures Treated With Titanium Elastic Nails (2005)

The purpose of this study was to analyze complications seen in children with femur fractures stabilized with titanium elastic nails, comparing their use in stable and unstable fracture patterns. A retrospective review was performed on 39 consecutive children with femur fractures treated with titanium elastic nails. Patients with comminuted or long oblique fractures were classified as having "length-unstable" fractures. Patients were analyzed qualitatively for any predictive factors or treatment variables that increased the risk of complications. There were 24 patients with complications (62%). Eight patients (21%) underwent unplanned surgery prior to complete fracture union. Six of the eight requiring unplanned surgery were treated for "length-unstable" fractures. The complications that required unplanned surgery for either prominent nails or loss of reduction occurred more commonly in unstable non-transverse fracture patterns. The authors conclude that in patients with "length-unstable" femur fractures, consideration should be given to methods of treatment other than titanium flexible intramedullary nails.
High Accuracy Analog Differentiator (1972)

A second order bandpass filter with the proper choice of damping ratio has been adapted for use as a high accuracy analog differentiator. Curves showing differentiator gain error as a function of damping ratio are given along with the gain error of the ``standard'' analog differentiating circuit. For a gain error of 1%, the differentiator bandwidth is reduced by a factor of 6 compared to the bandwidth necessary with the ``standard'' differentiating circuit. The reduced bandwidth results in lower wideband noise.
Renewed X-ray activity in GX 339-4 (2004)

https://www.astronomerstelegram.org/?read=231
Current Status and Limitations of Myocardial Infarction Large Animal Models in Cardiovascular Translational Research (2021)

Establishing an appropriate disease model that mimics the complexities of human cardiovascular disease is critical for evaluating the clinical efficacy and translation success. The multifaceted and complex nature of human ischemic heart disease is difficult to recapitulate in animal models. This difficulty is often compounded by the methodological biases introduced in animal studies. Considerable variations across animal species, modifications made in surgical procedures, and inadequate randomization, sample size calculation, blinding, and heterogeneity of animal models used often produce preclinical cardiovascular research that looks promising but is irreproducible and not translatable. Moreover, many published papers are not transparent enough for other investigators to verify the feasibility of the studies and the therapeutics' efficacy. Unfortunately, successful translation of these innovative therapies in such a closed and biased research is difficult. This review discusses some challenges in current preclinical myocardial infarction research, focusing on the following three major inhibitors for its successful translation: Inappropriate disease model, frequent modifications to surgical procedures, and insufficient reporting transparency.
conTACT - A Vibrotactile Display for Computer Aided Surgery (2007)

In this paper the concept and the first proving experiments of a navigation system for assistance during surgical interventions is presented. Novel aspects of this system are a new approach to transmit the navigation information to the surgeon. Contrary to known navigation systems the proposed approach does not only use visual support but provides information primarily by tactile stimuli. So the surgeon is not constrained to avert the gaze from the field of surgery during the navigation process. This paper concludes with the experimental evaluation of signal perception and a positioning task with tactile transmission of the navigation information
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes (2002)

Histone deacetylases (HDACs) are thought to function as critical mediators of transcriptional repression. However, the physiological targets and posttranslational modifications of the class II HDACs are largely unknown. Here we show that the C terminus of HDAC 6 is both necessary and sufficient for specific association with polyubiquitin. This region contains a putative zinc finger but lacks significant similarity to other known ubiquitin binding domains. Thus, we have designated this region as a PAZ domain, for Polyubiquitin Associated Zinc finger. Although the PAZ domain possesses homology with the zinc finger of deubiquitinating enzymes, it is dispensable for the deubiquitinating activity we find associated with HDAC6 following immunopurification. We also show that both HDAC 5 and HDAC 6 are ubiquitinated in vitro and in vivo. However, both of these proteins are stable in vivo and do not appear to be targeted for rapid degradation by the proteasome. Thus, HDAC6 is linked to the ubiquitin system via ubiquitin conjugation, polyubiquitin binding, and copurification with deubiquitinating enzymes.
Light sources (1976)

The selection of a system for optical communications is largely governed by the availability of the necessary components. Although through-the-atmosphere systems have some applicability, they are generally restricted to small installations where their inherent limitations are tolerable. The optical transmission medium of greater importance for the future is a glass or plastic fiber, and therefore the properties of these fibers—their absorption, dispersion, mechanical strength, and so on—are all-important.
Laser generated cavitation near a curved surface (2000)

Summary form only. Damage to solids in liquids exposed to cavitation is an important topic in a range of fluid-mechanical systems such as hydraulic pumps and propellers. Cavitation damage is generally believed to be due to non-symmetrical collapse of bubbles, on or near the liquid solid boundary. Individual damage sites often grow with time. This may be simply because many cavities are formed in the same location or perhaps irregularities in the surface encourage liquid flow leading to further cavity production and further damage. Most previous work has been on smooth flat surfaces. This paper describes experiments to investigate the growth and collapse of laser generated cavities in water near curved surfaces.
Practical use of the pessary. (2000)

The pessary is an effective tool in the management of a number of gynecologic problems. The pessary is most commonly used in the management of pelvic support defects such as cystocele and rectocele. Pessaries can also be used in the treatment of stress urinary incontinence. The wide variety of pessary styles may cause confusion for physicians during the initial selection of the pessary. However, an understanding of the different styles and their uses will enable physicians to make an appropriate choice. Complications can be minimized with simple vaginal hygiene and regular follow-up visits.
Waterproofing and Water and Oil Repellency (2009)

Abstract The measurement of contact angles is a convenient means for judging the degree of wetting or repellency for a liquid on a planar solid surface. A number of methods have been developed for estimating advancing contact angles of liquids in surfaces,. A repellent material functions by lowering the surface energy to a value such that the liquid now has a higher advancing contact angle on the surface.There are six classes of repellents textile finishes; fluorochemicals; silicones; resin‐based finishes; waxes and wax‐metal emulsions; and organometallic complexes. Fabric construction affects the performance of the water repellent. Waterproof/breathable fabrics are usually natural or synthetic fabrics that are laminated or coated in some sort of waterproof material. Leather is treated to make the surface water repellent, without reducing permeability to water vapor. Sizing agents are used to treat paper. Water resistance is an important factor in concrete and masonry construction for safety, health, and comfort of a building's occupants. Wood is subject to water infiltration by both liquids and vapors. After‐market repellents that are applied after wood structures are built, are readily available.
Membrane Separations in Biotechnology (2001)

Protein transport in ultrafiltration hollow-fibre bioreactors for mammalian cell culture vortex flow filtration for cell separation in bioreactor operations crossflow membrane filtration of fermentation broth cross-flow microfiltration with backpulsing the effects of different membrane modular systems on the performance of cross flow filtration of picha pastoris suspensions filter applications in product recovery processes ultrafiltration membranes in the vaccine industry protein purification by affinity ultrafiltration process development for the isolation of a recombinant immunofusion protein using a membrane adsorber high performance tangential flow filtration virus removal by ultrafiltration - a case study with diaspirin crosslinked haemoglobin (DCLHb) scale up and virus clearance studies on viral filtration in monoclonal antibody manufacture virus removal filtration.