gebhart/patrepeval huggingface dataset:
A Parallel Debugger Based on Cluster Operating System Using B/S Structure (2009)

The design of a parallel debugger is indispensable and yet still challenging in developing tools for parallel environments. This paper focuses on the design and implementation of an actual parallel debugger, which has been realized on clusters is of a typical browser/server structure. A friendly user interface is provided, which visualizes the tedious process of debugging, The user interfaces, as clients, can be distributed far away from the server, which makes it easy for the client end to execute programs on the server machine. The task management module on debugging nodes, receiving debugging commands and sending results.
Differential Involvement of IκB Kinases α and β in Cytokine- and Insulin-Induced Mammalian Target of Rapamycin Activation Determined by Akt (2008)

The mammalian target of rapamycin (mTOR) is a mediator of cell growth, survival, and energy metabolism at least partly through its ability to regulate mRNA translation. mTOR is activated downstream of growth factors such as insulin, cytokines such as TNF, and Akt-dependent signaling associated with oncoprotein expression. mTOR is negatively controlled by the tuberous sclerosis complex 1/2 (TSC1/2), and activation of Akt induces phosphorylation of TSC2, which blocks the repressive TSC1/2 activity. Previously, we showed that activation of mTOR in PTEN-deficient cancer cells involves IkappaB kinase (IKK) alpha, a catalytic subunit of the IKK complex that controls NF-kappaB activation. Recently, a distinct IKK subunit, IKKbeta, was shown to phosphorylate TSC1 to promote mTOR activation in an Akt-independent manner in certain cells stimulated with TNF and in some cancer cells. In this study, we have explored the involvement of both IKKalpha and IKKbeta in insulin- and TNF-induced mTOR activation. Insulin activation of mTOR requires Akt in a manner that involves IKKalpha, preferentially to IKKbeta, and TSC2 phosphorylation. TNF, in most cells examined, activates Akt to use IKKalpha to control mTOR activation. In MCF7 cells, TNF does not activate Akt and requires IKKbeta to activate mTOR. The results show that Akt-dependent signaling, induced by cytokines or insulin, alters the IKK subunit-dependent control of mTOR.
A fast algorithm for ak-NN classifier based on the branch and bound method and computational quantity estimation (2000)

The nearest neighbor rule or k-nearest neighbor rule is a technique of nonparametric pattern recognition. Its algorithm is simple and the error is smaller than twice the Bayes error if there are enough training samples. However, it requires an enormous amount of computation, proportional to the number of samples and the number of dimensions of the feature vector. In this paper, a fast algorithm for the k-nearest neighbor rule based on the branch and bound method is proposed. Moreover, a new training algorithm for constructing a search tree that can reduce the computational quantity is proposed. Experimental results show the effectiveness of the proposed algorithms. © 2000 Scripta Technica, Syst Comp Jpn, 31(6): 1–9, 2000
Kojic Acid as an Anti-speck Agent (1988)

Journal Article Kojic Acid as an Anti-speck Agent Get access Keijiro Uchino, Keijiro Uchino Central Laboratory, Nippon Flour Mills Co., Ltd., Nurumizu; Atsugi, Kanagawa 243, Japan Search for other works by this author on: Oxford Academic Google Scholar Miyuki Nagawa, Miyuki Nagawa Central Laboratory, Nippon Flour Mills Co., Ltd., Nurumizu; Atsugi, Kanagawa 243, Japan Search for other works by this author on: Oxford Academic Google Scholar Yasuhiro Tonosaki, Yasuhiro Tonosaki Central Laboratory, Nippon Flour Mills Co., Ltd., Nurumizu; Atsugi, Kanagawa 243, Japan Search for other works by this author on: Oxford Academic Google Scholar Monta Oda, Monta Oda Central Laboratory, Nippon Flour Mills Co., Ltd., Nurumizu; Atsugi, Kanagawa 243, Japan Search for other works by this author on: Oxford Academic Google Scholar Akira Fukuchi Akira Fukuchi Central Laboratory, Nippon Flour Mills Co., Ltd., Nurumizu; Atsugi, Kanagawa 243, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 52, Issue 10, 1 October 1988, Pages 2609–2610, https://doi.org/10.1080/00021369.1988.10869087 Published: 01 October 1988 Article history Received: 03 March 1988 Published: 01 October 1988
Extrinsic Calibration and Odometry for Camera-LiDAR Systems (2019)

Most autonomous mobile robots are often equipped with monocular cameras and 3D LiDARs to perform vital tasks such as localization and mapping. In this paper, we present a two-stage extrinsic calibration method as well as a hybrid-residual-based odometry approach for such camera-LiDAR systems. Our extrinsic calibration method can estimate the relative transformation between the camera and the LiDAR with high accuracy, allowing us to better register the image and the point cloud data. After the calibration, our hybrid-residual-based odometry can be used to provide real-time, accurate odometry estimates. Our approach exploits both direct and indirect image features. The sensor motions are estimated by jointly minimizing reprojection residuals and photometric residuals in a nonlinear optimization procedure. Experiments are conducted to show the accuracy and robustness of our extrinsic calibration and odometry algorithms using both public and self-owned real-world datasets. The results suggest that our calibration method can provide accurate extrinsic parameters estimation without using initial values, and our odometry approach can achieve competitive estimation accuracy and robustness.
Mask Scentometer for Assessing Ambient Odors (2010)

This paper summarizes the development and operation of a Mask Scentometer and reports air dilution ratios measured during its use, which were used to establish the devices dilution-to-threshold settings. The Mask Scentometer is a facial respirator that has been modified to operate conceptually like the Barneby and Sutcliffe Box Scentometer. The Mask Scentometer is comprised of a -face respirator with two modified spin-on cartridges, one per side, which facilitate mixing ambient air with filtered air for presentation to an odor assessor at user-selected dilution ratios. The flow-weighted average dilution ratios produced within the Mask Scentometer were 18, 4.5, 2, 1, and 0.35. Investigators using the Mask Scentometer to measure ambient odor concentrations are advised to use these dilution-to-threshold values.
Oxygen sensing by the carotid body chemoreceptors (2000)

Carotid bodies are sensory organs that detect changes in arterial blood oxygen, and the ensuing reflexes are critical for maintaining homeostasis during hypoxemia. During the past decade, tremendous progress has been made toward understanding the cellular mechanisms underlying oxygen sensing at the carotid body. The purpose of this minireview is to highlight some recent concepts on sensory transduction and transmission at the carotid body. A bulk of evidence suggests that glomus (type I) cells are the initial site of transduction and that they release transmitters in response to hypoxia, which causes depolarization of nearby afferent nerve endings, leading to an increase in sensory discharge. There are two main hypotheses to explain the transduction process that triggers transmitter release. One hypothesis assumes that a biochemical event associated with a heme protein triggers the transduction cascade. The other hypothesis suggests that a K(+) channel protein is the oxygen sensor and that inhibition of this channel by hypoxia leading to depolarization is a seminal event in transduction. Although there is body of evidence supporting and questioning each of these, this review will try to point out that the truth lies somewhere in an interrelation between the two. Several transmitters have been identified in glomus cells, and they are released in response to hypoxia. However, their precise roles in sensory transmission remain uncertain. It is hoped that future studies involving transgenic animals with targeted disruption of genes encoding transmitters and their receptors may resolve some of the key issues surrounding the sensory transmission at the carotid body. Further studies are necessary to identify whether a single sensor or multiple oxygen sensors are needed for the transduction process.
Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism (2006)

Cancer cells exhibit increased glycolysis for ATP production due, in part, to respiration injury (the Warburg effect). Because ATP generation through glycolysis is less efficient than through mitochondrial respiration, how cancer cells with this metabolic disadvantage can survive the competition with other cells and eventually develop drug resistance is a long-standing paradox. We report that mitochondrial respiration defects lead to activation of the Akt survival pathway through a novel mechanism mediated by NADH. Respiration-deficient cells (rho(-)) harboring mitochondrial DNA deletion exhibit dependency on glycolysis, increased NADH, and activation of Akt, leading to drug resistance and survival advantage in hypoxia. Similarly, chemical inhibition of mitochondrial respiration and hypoxia also activates Akt. The increase in NADH caused by respiratory deficiency inactivates PTEN through a redox modification mechanism, leading to Akt activation. These findings provide a novel mechanistic insight into the Warburg effect and explain how metabolic alteration in cancer cells may gain a survival advantage and withstand therapeutic agents.
An Improvement on Precision in DDoS Source-End Detection with Multi-stream Combined HMM (2007)

DDoS (distributed denial-of-service) attacks detection system deployed in source-end network is superior in perceiving and throttling attacks before dataflows enter Internet, comparing with that in victim network. However, the current existed works in source- end network are so fragile, lead to a high false-positive rate and false-negative rate. This paper proposes a novel approach using multi-stream combined hidden Markov model (MC-HMM) on source-end DDoS detection for integrating multi-features simultaneously. The multi-features include the S-D-P three-tuple, TCP header Flags, and IP header ID field. Through experiments, we compared our original approach based on multiple detection features with other algorithms (such as CUSUM and HMM). The results present that our approach effectively reduces false-positive rate and false-negative rate, and improves the precision of detection.
Praxis der Umformtechnik (2005)

Die Umformtechnik setzt sich in der industriellen Fertigung immer mehr durch, da viele Formteile dadurch wirtschaftlicher hergestellt werden kÃ¶nnen. Dieses Fachbuch stellt die wichtigsten Umformverfahren und die dazugehÃ¶rigen Maschinen und Werkzeuge in prÃ¤gnanter Form vor. Es werden typische Anwendungen und Einsatzgebiete vorgestellt. Beispiele und Testfragen ermÃ¶glichen die Eigenkontrolle des Lernfortschritts. Neu in der 8. Auflage ist ein Beitrag zur inkrementellen Blechumformung. Animationen und Video-Clips auf der CD zeigen verschiedene Umformverfahren in sehr anschaulicher Art.
Energy Transfer in the Color-tunable Organic Electroluminescence by Voltage Modulation (2001)

There have been a large number of documents and patents on organic/polymer electrolumi- nescence devices, in addition a good many organic and polymer materials have been successfully synthesized since the first report of high performance double-layer organic light-emitting device(OLED) by C. W. Tang in 1987, and much progress has been made in this field. Study on the dye-doped organic light-emitting diodes is very significant. And a useful technique for altering the color of OLEDs involves the doping of a small amount of a fluorescent dye into one of the organic layers of an OLED. But little study on the color- tunable organic electroluminescence by the voltage applied at a doping level is reported. In this work, dye(Rubrene) was doped into poly( n-vinylcarbazole) (PVK) at different weight ratios and the characters of photoluminescence and electroluminscence were studied. The device structure of ITO/ PVK: Rubrene/Al was employed . The result shows that there are great difference between the photolumi- nescence and electroluminescence at a doping ratio of 2wt%. It is concluded that energy transfer in these dye-doped devices occurs by Forster energy transfer processes. And the trap effect of electrons of Rubrene on holes of PVK results in different combination probability of PVK exciton in photoluminescence and electroluminescence. The two cases result in the difference between the spectrum of photoluminescence and that of electroluminscence. At the same time, EL devices with Rubrene doped PVK as emission layer are color- tunable when the bias voltage was increased. It indicates that the energy transfer process from PVK to Rubrene is not complete. And the combination probability of PVK exciton which does not contribute to the emmision of Rubrene is increased when the bias voltage increases.
Dihydropyrimidine Dehydrogenase Gene as a Major Predictor of Severe 5-Fluorouracil Toxicity (2011)

The importance of polymorphisms in the dihydropyrimidine dehydrogenase (DPD) gene (DPYD) for the prediction of severe toxicity in 5-fluorouracil (5-FU) based chemotherapy has been controversially debated. As a key enzyme in the catabolism of 5-FU, DPD is the top candidate for pharmacogenetic studies on 5-FU toxicity, since a reduced DPD activity is thought to result in an increased half-life of the drug, and thus, an increased risk of toxicity. Here, we review the current knowledge on well-known and frequently studied DPYD variants such as the c.1905+1G>A splice site variant, as well as the recent discoveries of important functional variation in the noncoding regions of DPYD. We also outline future directions that are needed to further improve the risk assessment of 5-FU toxicity, in particular with respect to metabolic profiling and in the context of different combination therapeutic regimens, in which 5-FU is used today.
Midkine Enhances Fibrinolytic Activity of Bovine Endothelial Cells (1995)

A hitherto unknown function of midkine (MK) was found in the regulation of fibrinolytic activity of vascular endothelial cells. Recombinant murine MK enhanced plasminogen activator (PA)/plasmin levels in bovine aortic endothelial cells (BAECs) in a dose- and time-dependent manner. After incubation with 10 ng/ml MK for 18 h, PA and plasmin levels increased 6- and 4-fold, respectively. This effect was attributed to a moderate upregulation of urokinase-type PA expression as well as to a significant down-regulation of PA inhibitor-1 (PAI-1) expression. BAECs constitutively synthesized and secreted MK and its production was enhanced 2-fold with 1 microM retinoic acid or 10 microM retinol. It was found that MK served as a substrate for tissue transglutaminase. In the culture medium, MK existed as a transglutaminase-mediated complex of 36 kDa. Addition of anti-MK antibody to BAEC cultures resulted in a decrease of basal PA activity and an increase of basal PAI-1 levels and attenuated the ability of retinol to enhance PA activity 50% and potentiated the ability to increase PAI-1 levels 4-fold. Furthermore, MK and basic fibroblast growth factor (bFGF) acted more than additively in enhancing PA levels. We conclude that in BAECs MK is a novel autocrine factor sustaining the fibrinolytic property. MK functions as a mediator of retinoid and cooperates with bFGF to enhance fibrinolytic activity of BAECs.
Robust downlink power adjustment in cellular communication systems with antenna arrays at base stations (2003)

A serious shortcoming of current downlink power adjustment and transmit beamforming methods is that their performance may become severely degraded when the downlink channel correlation (DCC) matrices are known imprecisely at base stations. A new downlink power adjustment method is proposed which provides a substantially improved robustness against imperfect knowledge of the wireless channel by means of maintaining the required quality of service (QoS) for the worst-case channel uncertainty. Our method can be straightforwardly used in a conjunction with any existing transmit beamforming techniques.
1,6-Dinitropyrene: Mutagenicity in <italic>Salmonella</italic> and Carcinogenicity in BALB/c Mice<xref ref-type="fn" rid="FN2">2</xref> (1984)

In tests on the carcinogenicity of 1,6-dinitropyrene [(1,6-DNP) CAS: 42397-64-8] and 1-nitropyrene [(1-NP) CAS: 5522-43-0], 0.1 mg of each compound was inoculated sc into BALB/c mice once a week for 20 weeks. In the group given injections of 1,6-DNP the first tumor appeared on day 112, and 10 of the 20 mice developed tumors at the injection site by 45 weeks after the first injection. However, no tumors were induced in any of the mice that received injections of 1-NP. All of the induced tumors were transplantable for more than five generations in male BALB/c mice. Most of the tumors showed the characteristic histologic features of malignant fibrous histiocytoma.
Flow-Induced Deformation and Desorption of Adsorbed Polymers (1998)

The influence of shear flow of solvent past poly(methyl methacrylate) chains adsorbed onto germanium oxide from dilute carbon tetrachloride solution (a near-θ solvent) was studied at shear rates from 0 to 4 × 104 s-1 with the new apparatus described in this paper. Both the adsorbed amount and the flow-induced surface orientation (surface dichroism) were measured. The method involved measurements of infrared spectroscopy in attenuated total reflection (FTIR-ATR) using a hemispherical ATR crystal whose position with respect to the incident infrared source was rotated by 90° during the experiment in order to measure infrared absorbance in orthogonal directions. shear flow appeared to flatten the adsorbed PMMA layer relative to the surface. However, alignment of the polymer orientation in the direction of flow was found to be small. This suggests that shear-induced desorption (controlled by stress) and relaxation in response to deformation within the adsorbed layer (controlled by time) may be largely independent.
La difusión del fondo histórico de la Universidad Complutense de Madrid: proyecto Dioscórides Web (2002)

Desarrollo en el ano 2002 de una pasarela que permitio la edicion Web de los libros del fondo bibliografico antiguo de la UCM digitalizados en la Biblioteca digital Dioscorides, cuyo acceso hasta ese momento solo era posible desde la red de la propia Universidad.
Asynchronous interconnect for synchronous soc design (2004)

System-on-chip (SoC) designs integrate a variety of cores and I/O interfaces, which usually operate at different clock frequencies. Communication between unlocked clock domains requires careful synchronization, which inevitably introduces metastability and some uncertainty in timing. Thus, any chip with multiple clock domains is already globally asynchronous. We have devised a more elegant and efficient solution to the multiple-clock-domain problem. Instead of gluing synchronous domains directly to each other with clock-domain bridges, we use asynchronous-circuit design techniques to handle all clock-domain crossing as well as all cross-chip communication and routing. The phase-locked loop (PLL) and clock distribution can be entirely local to each synchronous core, easing timing closure and improving the reusability of cores across multiple designs. Our solution, Nexus, is a globally asynchronous, locally synchronous (GALS) interconnect that features a 16-port, 36-bit asynchronous crossbar. The crossbar connects through asynchronous channels to clock-domain converters for each synchronous module. To ensure that Nexus will work robustly in a commercial application, we developed and applied many verification and test strategies, including novel variations of noise analysis, timing analysis, and fault and delay testing.
A Fluorescence Polarization Assay To Detect Steroid Hormone Traces in Milk (2015)

Steroids are a class of hormones improperly used in livestock as growth-promoting agents. Due to their high risk for human health, the European Union (EU) has strictly forbidden the administration of all natural and synthetic steroid hormones to food-producing animals, and the development of new rapid detection methods are greatly encouraged. This work reports a novel fluorescence polarization assay, ready to use, capable of detecting 17β-estradiol directly in milk samples with a low limit of detection of <10 pmol. It is based on the coupling of monospecific antibodies against 17β-estradiol and fluorophores, capable of modulating the fluorescence polarization emission on the basis of the specific binding of antibodies to fluorescence-labeled 17β-estradiol derivative. The successful detection of 17β-estradiol has disclosed the development of an efficient method, easily extensible to any food matrix and having the potential to become a milestone in food quality and safety.
The Role of Flavonol Glycosides and Carotenoids in Protecting Soybean from Ultraviolet-B Damage (1993)

The increase in ultraviolet-B (UV-B; 0.290-0.320 [mu]m) radiation received by plants due to stratospheric ozone depletion heightens the importance of understanding UV-B tolerance. Photosynthetic tissue is believed to be protected from UV-B radiation by UV-B-absorbing compounds (e.g. flavonoids). Although synthesis of flavonoids is induced by UV-B radiation, its protective role on photosynthetic pigments has not been clearly demonstrated. This results in part from the design of UV-B experiments in which experimental UV-A irradiance has not been carefully controlled, since blue/UV-A radiation is involved in the biosynthesis of the photosynthetic pigments. The relationship of flavonoids to photosynthetic performance, photosynthetic pigments, and growth measures was examined in an experiment where UV-A control groups were included at two biologically effective daily UV-B irradiances, 14.1 and 10.7 kJ m-2. Normal, chlorophyll-deficient, and flavonoid-deficient pigment isolines of two soybean (Glycine max) cultivars that produced different flavonol glycosides (Harosoy produced kaempferol, Clark produced quercetin and kaempferol) were examined. Plants with higher levels of total flavonoids, not specific flavonol glycosides, were more UV-B tolerant as determined by growth, pigment, and gas-exchange variables. Regression analyses indicated no direct relationship between photosynthesis and leaf levels of UV-B-absorbing compounds. UV-B radiation increased photosynthetic pigment content, along with UV-B-absorbing compounds, but only the former (especially carotenoids) was related to total biomass (r2 = 0.61, linear) and to photosynthetic efficiency (negative, exponential relationship, r2 = 0.82). A reduction in photosynthesis was associated primarily with a stomatal limitation rather than photosystem II damage. This study suggests that both carotenoids and flavonoids may be involved in plant UV-B photoprotection, but only carotenoids are directly linked to photoprotection of photosynthetic function. These results additionally show the importance of UV-A control in UV-B experiments conducted using artificial lamps and filters.
Impact ionization rates for electrons and holes in Ga0.47In0.53As (1980)

We report the determination of the impact ionization rates for holes and electrons in Ga0.47In0.53As with the electric field oriented in the 〈100〉 direction. Our measurements show that the ionization rate for electrons α is greater than that for holes (β) by about a factor of 2 over electric fields ranging from 2.0×105 to 2.5×105 V cm−1 at 295 K.