gebhart/patrepeval huggingface dataset:
Near‐surface ocean velocity from infrared images: Global Optimal Solution to an inverse model (2008)

We address the problem of obtaining ocean surface velocities from sequences of thermal (AVHRR) space‐borne images by inverting the heat conservation equation (including sources of surface heat fluxes and vertical entrainment). We demonstrate the utility of the technique by deriving surface velocities from (1) The motion of a synthetic surface tracer in a numerical model and (2) a sequence of five actual AVHRR images from 1 day. Typical formulations of this tracer inversion problem yield too few equations at each pixel, which is often remedied by imposing additional constraints (e.g., horizontal divergence, vorticity, and energy). In contrast, we propose an alternate strategy to convert the underdetermined equation set to an overdetermined one. We divide the image scene into many subarrays and define velocities and sources within each subarray using bilinear expressions in terms of the corner points (called knots). In turn, all velocities and sources on the knots can be determined by seeking an optimum solution to these linear equations over the large scale, which we call the Global Optimal Solution (GOS). We test the accuracy of the GOS by contaminating the model output with up to 10% white noise but find that filtering the data with a Gaussian convolution filter yields velocities nearly indistinguishable from those without the added noise. We compare the GOS velocity fields with those from the numerical model and from the Maximum Cross Correlation (MCC) technique. A histogram of the difference between GOS and numerical model velocities is narrower and more peaked than the similar comparison with MCC, irrespective of the time interval (Δ t = 2 or 4 h) between images. The calculation of the root mean square error difference between the GOS (and MCC) results and the model velocities indicates that the GOS/model error is only half that of the MCC/model error irrespective of the time interval (Δ t = 2 or 4 h) between images. Finally, the application of the technique to a sequence of five NOAA AVHRR images yields a velocity field, which we compare with that from a Coastal Ocean Dynamics Radar (CODAR) array. We find that the GOS velocities generally agree more closely with those from the CODAR than they do with those from the MCC. Specifically, the root mean square error obtained by differencing GOS and CODAR velocities is smaller than that from the similar calculation with MCC velocities. The magnitude of the complex correlation between GOS and CODAR is larger than that between MCC and CODAR. The phase of the complex correlation indicates that both MCC and GOS on average yield velocity vectors biased in the clockwise direction relative to the CODAR vectors for the period examined.
A Design and Experiment of Speed Controller with PI-Plus Bang-Bang Action for a DC Servomotor with Transistorized PWM Drives (1984)

A speed controller with proportional-integral (PI)-plus bang-bang action is proposed for dc servomotors with transistorized pulse width modulated (PWM) drives. The controller employs the PI-action when the magnitude of the error between the reference signal and the speed output signal is smaller than some precribed value. Otherwise, the controller produces the maximum allowable control signal with the integrator reset. Specifically, a mathematical analysis of the motor system with the proposed speed controller is presented and a rule of thumb for parameter design is provided.
Methyl viologen hydrogenase II, a new member of the hydrogenase family from Methanobacterium thermoautotrophicum delta H (1993)

Two methyl viologen hydrogenase (MVH) enzymes from Methanobacterium thermoautotrophicum delta H have been separated (resolution, Rs at 1.0) on a Mono Q column after chromatography on DEAE-Sephacel and Superose 6 Prep Grade. The newly discovered MVH (MVH II) was eluted at 0.5 M NaCl with a linear gradient of 0.45 to 0.65 M NaCl (100 ml). The previously described MVH (MVH I) eluted in a NaCl gradient at 0.56 M. The specific activities of MVH I and MVH II were 184.8 and 61.3 U/mg of protein, respectively, when enzyme activity was compared at pH 7.5, the optimal pH for MVH II. Gel electrophoresis in nondenaturing systems indicated that MVH I and MVH II had a similar molecular mass of 145 kDa. Denatured MVH II showed four protein bands (alpha, 50 kDa; beta, 44 kDa; gamma, 36 kDa; delta, 15 kDa), similar to MVH I. The N-terminal amino acid sequences of the alpha, gamma, and delta subunits of MVH II were identical with the sequences of the equivalent subunits of MVH I. However, the N-terminal amino acid sequence of the beta subunit of MVH II was totally different from the sequence of the beta subunit of MVH I. Both MVH I and MVH II had the same optimal temperature of 60 degrees C for maximum activity. The pH optima of MVH I and MVH II were 9.0 and 7.5, respectively. Most of the divalent metal ions tested significantly inhibited MVH I activity, but MVH II activity was only partially inhibited by some divalent cations. Both hydrogenases were shown to be stable for over 8 days at --20 degrees C under anaerobic conditions. When exposed to air, 90% of MVH I activity was lost within 2 min; however, MVH II lost only 50% of its activity in 3 h.
Evidence of increased secretion of apolipoprotein B-48-containing lipoproteins in subjects with type 2 diabetes (2007)

Patients with type 2 diabetes have high levels of triglyceride-rich lipoproteins (TRLs), including apolipoprotein B-48 (apoB-48)-containing TRLs of intestinal origin, but the mechanism leading to overaccumulation of these lipoproteins remains to be fully elucidated. Therefore, the objective of this study was to examine the in vivo kinetics of TRL apoB-48 and VLDL, intermediate density lipoprotein (IDL), and LDL apoB-100 in type 2 diabetic subjects (n = 11) and nondiabetic controls (n = 13) using a primed-constant infusion of l-[5,5,5-D(3)]leucine for 12 h in the fed state. Diabetic subjects had significantly higher fasting glycemia, higher fasting insulinemia, higher plasma triglyceride, and lower HDL-cholesterol levels than controls. Compared with controls, diabetic subjects had increased TRL apoB-48, VLDL apoB-100, and IDL apoB-100 pool sizes as a result of increased production rates (PRs) and reduced fractional catabolic rates of these lipoprotein subfractions. Furthermore, multiple linear regression analyses revealed that the diabetic/control status was an independent predictor of TRL apoB-48 PR and represented nearly 35% of its variance. These results suggest that the overaccumulation of TRLs seen in patients with type 2 diabetes is attributable to increased PRs of both intestinally derived apoB-48-containing lipoproteins and TRL apoB-100 of hepatic origin and to decreased catabolism of these subfractions.
Pathogenesis of Shipping Fever in Cattle (1980)

The textbook fatal case of acute "shipping fever" or Pasteurellosis is a fulminating bacterial fibrinous pneumonia which implies a sudden insult deep in the lung with an agent that causes marked vascular damage which in turn accounts for the edema and fibrin.
A high-speed Si lateral photodetector fabricated over an etched interdigital mesa (1980)

A new kind of high-speed photodetector has been constructed utilizing the anisotropic etching technique. It is demonstrated that, functioning as an edge-incident photodiode, the detector responds reliably to subnanosecond light pulses with 40% overall quantum efficiency. And, functioning as a phototransistor, it responds to cw radiation with a current gain. Compatibility with existing planar processing is another feature. Possible mechanisms involved are discussed.
CARBONIC ACID AZIDES (1928)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCARBONIC ACID AZIDESCharles Vinton HartCite this: J. Am. Chem. Soc. 1928, 50, 7, 1922–1930Publication Date (Print):July 1, 1928Publication History Published online1 May 2002Published inissue 1 July 1928https://pubs.acs.org/doi/10.1021/ja01394a017https://doi.org/10.1021/ja01394a017research-articleACS PublicationsRequest reuse permissionsArticle Views263Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Universal RNAi Triggers for the Specific Inhibition of Mutant Huntingtin, Atrophin-1, Ataxin-3, and Ataxin-7 Expression (2019)

The expansion of CAG repeats within the coding region of associated genes is responsible for nine inherited neurodegenerative disorders including Huntington's disease (HD), spinocerebellar ataxias (SCAs), and dentatorubral-pallidoluysian atrophy (DRPLA). Despite years of research aimed at developing an effective method of treatment, these diseases remain incurable and only their symptoms are controlled. The purpose of this study was to develop effective and allele-selective genetic tools for silencing the expression of mutated genes containing expanded CAG repeats. Here we show that repeat-targeting short hairpin RNAs preferentially reduce the levels of mutant huntingtin, atrophin-1, ataxin-3, and ataxin-7 proteins in patient-derived fibroblasts and may serve as universal allele-selective reagents for polyglutamine (polyQ) diseases.
The immunolocalization of protein gene product 9.5 using rabbit polyclonal and mouse monoclonal antibodies. (1988)

In order to assess the potential of protein gene product (PGP) 9.5 as a marker of the nervous and neuroendocrine systems, we examined its immunolocation in human, rat and guinea-pig tissues, using a rabbit polyclonal antiserum and two new mouse monoclonal antisera, I3C4 and 3IA3. Our results demonstrate immunoreactive PGP 9.5 in neurons and nerve fibres at all levels of the central and peripheral nervous system, in many neuroendocrine cells, in part of the renal tubule, in spermatogonia and Leydig cells of the testis, and in ova and in some cells of the pregnant and non-pregnant corpus luteum. In routinely processed tissues, standard immunohistochemical techniques using the polyclonal antibody demonstrated peripheral nerve fibres of all sizes with striking clarity.
Altering the anaerobic transcription factor FNR confers a hemolytic phenotype on <i>Escherichia coli</i> K12 (1998)

The recent outbreaks of Escherichia coli O157-associated food poisoning have focused attention on the virulence determinants of E. coli. Here, it is reported that single base substitutions in the fnr gene encoding the oxygen-responsive transcription regulator FNR (fumarate and nitrate reduction regulator) are sufficient to confer a hemolytic phenotype on E. coli K12, the widely used laboratory strain. The mechanism involves enhancing the expression of a normally dormant hemolysin gene (hlyE) located in the E. coli chromosome. The mutations direct single amino acid substitutions in the activating regions (AR1 and AR3) of FNR that contact RNA polymerase. It is concluded that altering a resident transcription regulator, or acquisition of a competent heterologous regulator, could generate a pool of hemolytic, and therefore more virulent, strains of E. coli in nature.
The Cost of ICU Delirium and Coma in the Intensive Care Unit Patient (2018)

Delirium is associated with substantial costs after accounting for time-varying illness severity and could be 20% higher (∼$22,500) if not for its association with early ICU mortality.
Assessing ocular irritation potential using a modified<i>ex vivo</i>rabbit eye test (2009)

We have evaluated the ocular irritancy potential of an unknown environmental contaminant, para-toluene sulfonic acid (pTSA), compared with that of known irritants, 5% sodium dodecyl sulfate (SDS) and 10% acetic acid (AA), using a simplified, ex vivo rabbit eye test modified to measure cytotoxicity as a mechanistic correlate to the Draize rabbit eye test. Rabbit eyes were obtained fresh within 24 hours from an abattoir and then exposed to 50 microL of test material. Eyes were then incubated intact for 3 hours or 1 day, and the corneas were removed, stained with calcein acetoxymethylester (AM)/ethidium homodimer (live/dead assay, Invitrogen Corp., Carlsbad, CA, USA), and evaluated by laser scanning confocal microscopy. The number of dead cells was then quantified and the difference was statistically compared. For corneas exposed to 1 ppm and 1% pTSA, there was no significant difference in the number of dead cells compared with water-exposed, control corneas at either 3 hours or 1 day after exposure. However, corneas exposed to 10% and 50% pTSA showed significantly increased (p < .0001) numbers of dead cells, averaging (mean +/- standard deviation) 486 +/- 133 and 1,052 +/- 101 cells/field of view (460 x 460 microm). The level of cytotoxicity was comparable with that observed for 10% AA, which averaged 409 +/- 142 cells/field of view. The data suggest that pTSA is an innocuous irritant at exposure levels environmentally encountered, but that higher concentrations (10% and above) might be considered a slight to mild irritant. We conclude that this modified ex vivo rabbit eye test using the live/dead assay may be a useful model for developing ocular irritation assays.
Regulation of Compound Leaf Development in <i>Medicago truncatula</i> by <i>Fused Compound Leaf1,</i> a Class M <i>KNOX</i> Gene  (2011)

Medicago truncatula is a legume species belonging to the inverted repeat lacking clade (IRLC) with trifoliolate compound leaves. However, the regulatory mechanisms underlying development of trifoliolate leaves in legumes remain largely unknown. Here, we report isolation and characterization of fused compound leaf1 (fcl1) mutants of M. truncatula. Phenotypic analysis suggests that FCL1 plays a positive role in boundary separation and proximal-distal axis development of compound leaves. Map-based cloning indicates that FCL1 encodes a class M KNOX protein that harbors the MEINOX domain but lacks the homeodomain. Yeast two-hybrid assays show that FCL1 interacts with a subset of Arabidopsis thaliana BEL1-like proteins with slightly different substrate specificities from the Arabidopsis homolog KNATM-B. Double mutant analyses with M. truncatula single leaflet1 (sgl1) and palmate-like pentafoliata1 (palm1) leaf mutants show that fcl1 is epistatic to palm1 and sgl1 is epistatic to fcl1 in terms of leaf complexity and that SGL1 and FCL1 act additively and are required for petiole development. Previous studies have shown that the canonical KNOX proteins are not involved in compound leaf development in IRLC legumes. The identification of FCL1 supports the role of a truncated KNOX protein in compound leaf development in M. truncatula.
γ‐Peptides Forming More Stable Secondary Structures than α‐Peptides: Synthesis and helical NMR‐solution structure of the γ‐hexapeptide analog of H‐(Val‐Ala‐Leu)<sub>2</sub>‐OH (1998)

Abstract For a comparison with the corresponding α‐ and β‐hexapeptides H‐(Val‐Ala‐Leu) 2 ‐OH (A) and H‐(β‐HVal‐β‐HAla‐β‐HLeu) 2 ‐OH ( B ), we have now prepared the corresponding γ‐hexapeptide 1 built from the homochirally similar ( S )‐4‐aminobutanoic acid, ( R )‐4‐amino‐5‐methylhexanoic acid, and ( R )‐4‐amino‐6‐methylheptanoic acid. The precursors were prepared either by double Arndt ‐ Eistert homologation of the protected amino acids Boc‐Val‐OH, Boc‐Ala‐OH, and Boc‐Leu‐OH ( Schemes 1 and 2 ), or by the superior route involving olefination/hydrogenation of the corresponding aldehydes (Boc‐valinal, Boc‐alaninal, and Boc‐leucinal; Scheme 3 ). Conventional peptide‐coupling methodology (EDC/HOBt) furnished the γ‐hexapeptide 1 (through the intermediate γ‐di‐ and γ‐tripeptide derivatives 9 – 11 ). Analysis of NMR measurements in (D 5 )pyridine and CD 3 OH solution (COSY, TOCSY, HSQC, HMBC, ROESY) reveals that the γ‐hexapeptide 1 adopts a right ‐handed helical structure (( P )‐ 2.6 1 helix of ca. 5‐Å pitch, containing 14‐membered H‐bonded rings) which is to be compared with the left ‐handed helix of the corresponding β‐peptide B (( M )‐ 3 1 helix of 5‐Å pitch, 14‐membered H‐bonded rings) and with the familiar right ‐handed, so‐called α‐helix of α‐peptides (( P )‐ 3.6 1 helix of 5.4‐Å pitch, 13‐membered rings). Like the helix sense, the helix dipole reverses when going from α‐, (N + → C) to β‐(C + → N) to γ‐peptides (N + → C). The surprising difference between the natural α‐, and the analogous β‐ and γ‐peptides is that the helix stability increases upon homologation of the residues.
DeepCF: A Unified Framework of Representation Learning and Matching Function Learning in Recommender System (2019)

In general, recommendation can be viewed as a matching problem, i.e., match proper items for proper users. However, due to the huge semantic gap between users and items, it's almost impossible to directly match users and items in their initial representation spaces. To solve this problem, many methods have been studied, which can be generally categorized into two types, i.e., representation learning-based CF methods and matching function learning-based CF methods. Representation learning-based CF methods try to map users and items into a common representation space. In this case, the higher similarity between a user and an item in that space implies they match better. Matching function learning-based CF methods try to directly learn the complex matching function that maps user-item pairs to matching scores. Although both methods are well developed, they suffer from two fundamental flaws, i.e., the limited expressiveness of dot product and the weakness in capturing low-rank relations respectively. To this end, we propose a general framework named DeepCF, short for Deep Collaborative Filtering, to combine the strengths of the two types of methods and overcome such flaws. Extensive experiments on four publicly available datasets demonstrate the effectiveness of the proposed DeepCF framework.
Cyanide Removal from Aqueous Waste by Polymerization (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyanide Removal from Aqueous Waste by PolymerizationChung Y. Shen and Paul E. R. Nordquist Jr.Cite this: Ind. Eng. Chem. Prod. Res. Dev. 1974, 13, 1, 70–75Publication Date (Print):March 1, 1974Publication History Published online1 May 2002Published inissue 1 March 1974https://pubs.acs.org/doi/10.1021/i360049a014https://doi.org/10.1021/i360049a014research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Chameleon – a group communication framework for smartphones (2014)

Summary This paper reports about our experience in designing and developing Chameleon , a highly portable and adaptable group communication framework for smartphones. Chameleon owes its level of portability to several design choices, including the following: (i) a layered architecture, where the headers of each layer have a standard XML‐based format, enabling automatic, error‐resistant generation of efficient serialization code in any platform; (ii) reliance only on the J2ME library, which serves as least common denominator for Java dialects and facilitates automatic translation to.NET; (iii) having flexible membership models; and (iv) supporting multiple concurrent protocol stacks.Through a single codebase, Chameleon is currently available as an open‐source project for J2ME, J2SE, Android,.NET CF, and.NET. Chameleon is easily extendable and is bundled with tools, configurations, and third‐party code tuned in a way that lifts some of the burden normally associated with multiplatform development for smartphones. Both the header generation from XML and automatic translation to.NET features of Chameleon are readily available to any application that is based on it. Chameleon 's threading model separates between execution of internal layers and application's code and by that protects one from the other. As we describe in the paper, it simplifies layers' development and allows the protocol stack to easily block application calls when this is required by internal algorithms. Additionally, this model simplifies testing, and an extensive testing framework is supplied along with Chameleon , which is also usable for testing of application‐specific layers. Copyright © 2014 John Wiley & Sons, Ltd.
AtOPT3, a Member of the Oligopeptide Transporter Family, Is Essential for Embryo Development in Arabidopsis (2002)

A T-DNA-tagged population of Arabidopsis was screened for mutations in AtOPT3, which encodes a member of the oligopeptide (OPT) family of peptide transporters, and a recessive mutant allele, opt3, was identified. Phenotypic analysis of opt3 showed that most homozygous embryos were arrested at or before the octant stage of embryo development and that none showed the usual periclinal division leading to the formation of the protoderm. This defective phenotype could be reversed by complementation with the full-length, wild-type AtOPT3 gene. A beta-glucuronidase (GUS) fusion to DNA sequences upstream of the putative AtOPT3 ATG start codon was constructed, and the expression pattern was assayed in transgenic plants. AtOPT3 was expressed in the vascular tissues of seedlings and mature plants as well as in pollen. Consistent with the function of AtOPT3 in embryogenesis, AtOPT3::GUS expression also was detected in developing embryos and in the maternal tissues of seeds. These data suggest a critical role for peptide transport in early embryo development.
Synthesis and Characterization of 1,2-Dimethyl Imidazolium Ionic Liquids and Their Catalytic Activities (2015)

The synthesis of substituted imidazolium-type ionic liquids via a simple method is described. Our synthesized ionic liquids are more useful in the catalytic behavior of the Mannich reaction.