gebhart/patrepeval huggingface dataset:
Content based image retrieval using textural features based on pyramid-structure wavelet transform (2011)

Image Retrieval system is an effective and efficient tool for managing large image databases. A content based image retrieval system allows the user to present a query image in order to retrieve images stored in the database according to their similarity to the query image. In this paper content based image retrieval method is used as diagnosis aid in medical fields. The main objective of this paper is to evaluate the retrieval system based on Texture features. The texture features are extracted by using pyramidal wavelet transform. The major advantage of such an approach is that little human intervention is required. The method is evaluated on Diabetic Retinopathy Database (DRD). Here the precision rate obtained is about 60% for DRD images.
Cartografía de QTL de la resistencia a la pudrición de la mazorca (Fusarium moniliforme) en maíz de Valles Altos, MÉXICO (2001)

Ear rot, caused by Fusarium moniliforme causes substantial losses in highland maize (Zea mays L.) in Mexico. The objectives of this study were to identify ...
DNA Detection on Plastic:  Surface Activation Protocol To Convert Polycarbonate Substrates to Biochip Platforms (2006)

A mild and efficient surface activation protocol to convert polycarbonate (PC) substrates, e.g., plastic bases of compact disks, to biochip platforms for DNA probe immobilization and target detection is described. The preparation procedure (activation, patterning, and coupling) is simple and effective; the on-chip hybridization is sensitive and selective. Particularly, UV/ozone treatment of PC sheets produces a hydrophilic surface with a high density of reactive carboxylic acid groups [(4.8 +/- 0.2) x 10-10 mol/cm2] in less than 10 min at ambient conditions, and no significant aging or physical damage to the substrate is observed. Covalent immobilization of DNA probes via both passive (reagent-less photopatterning and coupling in bulk solution phase) and flow-through (creation of microarrays with microfluidic channel plates) procedures has been demonstrated. Subsequent hybridization shows uniform and strong fluorescent signals for complementary target DNA and allows clear discrimination between fully complementary targets and strands with a single base-pair mismatch. The surface chemistry described herein will facilitate the development of disposable plastic biochips (not limited to DNA microarrays) and the fabrication of biomedical devices that are readable with conventional optical drives.
Variational Distance-Dependent Image Restoration (2007)

There is a need to restore color images that suffer from distance-dependent degradation during acquisition. This occurs, for example, when imaging through scattering media. There, signal attenuation worsens with the distance of an object from the camera. A 'naive' restoration may attempt to restore the image by amplifying the signal in each pixel according to the distance of its corresponding object. This, however, would amplify the noise in a nonuniform manner. Moreover, standard space-invariant de-noising over-blurs close by objects (which have low noise), or insufficiently smoothes distant objects (which are very noisy). We present a variational method to overcome this problem. It uses a regularization operator which is distance dependent, in addition to being edge-preserving and color-channel coupled. Minimizing this functional results in a scheme of reconstruction-while-denoising. It preserves important features, such as the texture of close by objects and edges of distant ones. A restoration algorithm is presented for reconstructing color images taken through haze. The algorithm also restores the path radiance, which is equivalent to the distance map. We demonstrate the approach experimentally.
Immune cell lethality induced by streptococcal pyrogenic exotoxin A and endotoxin (1992)

Streptococcal pyrogenic exotoxin (SPE) A has many effects on the immune system, including immunolethality, which is characterized by a significant decrease in circulating immune cells as well as depletion of the spleen and lymph nodes prior to death of experimental animals. In this report, characterization of the mechanism of immunolethality has been undertaken. Synergistic induction of immunolethality was observed in vitro when human lymphocytes were treated with both SPE A and lipopolysaccharide (LPS). The same effect was demonstrated in the absence of a mitogenic response with the murine T-cell receptor, as well as in the absence of antigen-presenting cells and their secreted cytokines. The addition of antigen-presenting cells did not significantly affect lethality. SPE A directly interacted with LPS through interaction with ketodeoxyoctonate as demonstrated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and iodinated exotoxin overlays. This interaction was demonstrated to be important for immunolethality, since simultaneous addition of SPE A and LPS was required, whereas sequential addition of SPE A and LPS did not result in lethality. LPS appeared to be acting, in part, to enhance the cell-binding ability of SPE A, since SPE A could only be detected in A.E7 cell membrane preparations after simultaneous incubation with SPE A and LPS.
Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells (2007)

Chronic inflammation can augment tumor development in various types of cancers, including prostate cancer (PCa). Reduction of inflammation is therefore an important anticancer therapeutic opportunity. Here, we report four anti-proliferative phytocompounds in Wedelia chinensis, an oriental herbal medicine, identified through their ability to modulate the androgen receptor (AR) activation of transcription from prostate-specific antigen promoter in PCa cells. The 50% inhibition concentration values of indole-3-carboxylaldehyde, wedelolactone, luteolin and apigenin, were 34.9, 0.2, 2.4 and 9.8 muM, respectively. A formula that combined the phytocompounds in the same proportions as in the herbal extract decreased the dosage of each compound required to achieve maximal AR inhibition. In correlation with the AR suppression effect, these active compounds specifically inhibited the growth of AR-dependent PCa cells and as a combination formula they also synergistically suppressed growth in AR-dependent PCa cells. Our study has identified synergistic effects of active compounds in W. chinensis and demonstrated their potential in PCa prevention and therapy. The paradigm of multiple activities and synergism is a useful framework to investigate the therapeutic effects of whole extracts from assorted medicinal plant species.
Optical Readout Method for Solid State Dosemeters (1986)

Journal Article Optical Readout Method for Solid State Dosemeters Get access J.C. McDonald, J.C. McDonald Search for other works by this author on: Oxford Academic PubMed Google Scholar F.N. Eichner, F.N. Eichner Search for other works by this author on: Oxford Academic PubMed Google Scholar K.A. Stahl, K.A. Stahl Search for other works by this author on: Oxford Academic PubMed Google Scholar S.D. Miller S.D. Miller Search for other works by this author on: Oxford Academic PubMed Google Scholar Radiation Protection Dosimetry, Volume 17, Issue 1-4, 1 December 1986, Pages 329–331, https://doi.org/10.1093/oxfordjournals.rpd.a079834 Published: 01 December 1986
Deep Learning Reconstruction for 9-View Dual Energy CT Baggage Scanner (2018)

For homeland and transportation security applications, 2D X-ray explosive detection system (EDS) have been widely used, but they have limitations in recognizing 3D shape of the hidden objects. Among various types of 3D computed tomography (CT) systems to address this issue, this paper is interested in a stationary CT using fixed X-ray sources and detectors. However, due to the limited number of projection views, analytic reconstruction algorithms produce severe streaking artifacts. Inspired by recent success of deep learning approach for sparse view CT reconstruction, here we propose a novel image and sinogram domain deep learning architecture for 3D reconstruction from very sparse view measurement. The algorithm has been tested with the real data from a prototype 9-view dual energy stationary CT EDS carry-on baggage scanner developed by GEMSS Medical Systems, Korea, which confirms the superior reconstruction performance over the existing approaches.
Exposure to time varying magnetic fields associated with magnetic resonance imaging reduces fentanyl‐induced analgesia in mice (1988)

The effects of exposure to clinical magnetic resonance imaging (MRI) on analgesia induced by the mu opiate agonist, fentanyl, was examined in mice. During the dark period, adult male mice were exposed for 23.2 min to the time-varying (0.6 T/sec) magnetic field (TVMF) component of the MRI procedure. Following this exposure, the analgesic potency of fentanyl citrate (0.1 mg/kg) was determined at 5, 10, 15, and 30 min post-injection, using a thermal test stimulus (hot-plate 50 degrees C). Exposure to the magnetic-field gradients attenuated the fentanyl-induced analgesia in a manner comparable to that previously observed with morphine. These results indicate that the time-varying magnetic fields associated with MRI have significant inhibitory effects on the analgesic effects of specific mu-opiate-directed ligands.
Direct Observation of 2D Electrostatics and Ohmic Contacts in Template-Grown Graphene/WS<sub>2</sub> Heterostructures (2017)

Large-area two-dimensional (2D) heterojunctions are promising building blocks of 2D circuits. Understanding their intriguing electrostatics is pivotal but largely hindered by the lack of direct observations. Here graphene-WS<sub>2</sub> heterojunctions are prepared over large areas using a seedless ambient-pressure chemical vapor deposition technique. Kelvin probe force microscopy, photoluminescence spectroscopy, and scanning tunneling microscopy characterize the doping in graphene-WS<sub>2</sub> heterojunctions as-grown on sapphire and transferred to SiO<sub>2</sub> with and without thermal annealing. Both p-n and n-n junctions are observed, and a flat-band condition (zero Schottky barrier height) is found for lightly n-doped WS<sub>2</sub>, promising low-resistance ohmic contacts. This indicates a more favorable band alignment for graphene-WS<sub>2</sub> than has been predicted, likely explaining the low barriers observed in transport experiments on similar heterojunctions. Electrostatic modeling demonstrates that the large depletion width of the graphene-WS<sub>2</sub> junction reflects the electrostatics of the one-dimensional junction between two-dimensional materials.
Non-destructive on-chip imaging flow cell-sorting system for on-chip cellomics (2012)

We have developed a non-destructive imaging flow cell-sorting system using an ultra-high-speed camera (shutter speed of 1/10,000 s) with a real-time image analysis unit and a poly(methyl methacrylate) (PMMA)-based disposable microfluidic chip for single-cell-based on-chip cellomics. It has a 3-D micropipetting device that supports fully automated sorting and collection of samples. The entire fluidic system is implemented in a disposable plastic chip, enabling biological samples to be lined up in a laminar flow using hydrodynamic focusing. Its optical system enables direct observation-based cell identification using specific image indexes and phase-contrast/fluorescence microscopy, real-time image processing. It has a non-destructive, wider dynamic range, sorting procedure using mild electrostatic force in a laminar flow; agarose gel electrodes are used to prevent electrode loss and electrolysis bubble formation. The microreservoir used for recultivating collected target cells is contamination-free. An integrated ultra-high-speed droplet polymerase chain reaction measurement module is used for DNA/mRNA analysis of the collected target cells. This system was used to separate cardiomyocyte cells from a mixture of various cells. All the operations were automated using the 3-D micropipetting device. The results demonstrate that this imaging flow cell-sorting system is practically applicable for biological research and clinical diagnosis.
Keratin-associated protein micromaterials for medical and cosmetic applications (2009)

Procedure of preparation of keratin associated protein micromaterials from hair, wool and bristle like natural sources has been developed. Procedure involves a combination of chemical activation and enzymatic digestion of natural substrates. Keratin associated proteins could be applied as microscaffolds in medicine and cosmetics.
Replacement recombination in Lactococcus lactis (1991)

In the pUC18-derived integration plasmid pML336 there is a 5.3-kb chromosomal DNA fragment that carries the X-prolyl dipeptidyl aminopeptidase gene (pepXP). The gene was inactivated by the insertion of an erythromycin resistance determinant into its coding sequence. Covalently closed circular DNA of pML336 was used for the electrotransformation of Lactococcus lactis. In 2% of the erythromycin-resistant transformants the pepXP gene was inactivated by a double-crossover event (replacement recombination) between pML336 and the L. lactis chromosome. The other transformants in which the pepXP gene had not been inactivated carried a Campbell-type integrated copy of the plasmid. Loss of part of the Campbell-type integrated plasmid via recombination between 1.6-kb nontandem repeats occurred with low frequencies that varied between less than 2.8 x 10(-6) and 8.5 x 10(-6), producing cells with a chromosomal structure like that of cells in which replacement recombination had taken place.
A tool for component based design of embedded software (2002)

In this paper a new approach for building embedded applications is presented. The approach is based on the composition of reusable components with the addition of a contract principle for modelling non-functional constraints. Non-functional constraints are an important aspect of embedded systems, and this is why they are modelled separately. As such, the component view presented here differs from traditional component based views, where focus is laid on the functional part. The ideas discussed in the paper have been implemented in a tool. This tool enables the construction of embedded software by means of components and contracts. Currently, runtime mechanisms- that enable runtime monitoring of the contracts-are being included.
The minimal time detection algorithm of changes in control parameters and its application to flight systems (2002)

There exists a significant interest in enhancing current flight systems so that they can reconfigure the controls to maintain adequate levels of performance even if there are complete failures in one or more of the actuators or sensors. A control system is designed such that it can autonomously achieve a high level goal, while its components, plant models and control laws are not completely defined, either because they were not known at the design time or because they changed unexpected due to random changes. So, system parameters should be tracked on-line to build a highly adaptive control system even though there exists a random change. For this purpose, a new performance index that the author is developing is the speed of adaptation-how quickly does the system determine that a change occurred? Therefore, a new, robust algorithm that is optimized to minimize the time delay in detecting a change for a fixed false alarm probability is proposed. Simulation results show that the algorithm works fairly well and one of distinguishing properties is that detection delay of the algorithm is superior to that of the Whiteness test.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs (1995)

It is well established that endotoxin [lipopolysacharide (LPS)] induces pro-inflammatory cytokine production in monocytes, which is followed by secretion of the anti-inflammatory cytokine, IL-10. IL-10 down-regulates inflammatory response [tumor necrosis factor (TNF)-alpha, IL-1, IL-6, IL-8] as well as IL-10 synthesis itself. We wondered whether pro-inflammatory cytokines such as TNF-alpha may be involved in the regulation of human IL-10 synthesis. TNF-alpha induced de novo IL-10 mRNA expression in a dose-dependent manner but no IL-10 protein in human peripheral blood mononuclear cells. Furthermore, LPS-induced IL-10 gene and protein expression was significantly inhibited by neutralizing anti-TNF-alpha mAb. On the basis of these results, we conclude that TNF-alpha is involved in the up-regulation of its antagonist IL-10. Paradoxically, drugs that effectively inhibit expression of TNF-alpha via the elevation of intracellular cAMP level (iloprost, pentoxifylline, prostaglandin E2 and N6,2-O-dibutyryl cAMP) augmented the endotoxin-induced IL-10 synthesis at both protein and mRNA levels. In order to provide a basis for the analysis of the transcriptional regulation of the human IL-10 gene, we isolated a fragment of the human IL-10 gene containing 1308 bp of the 5' non-coding sequence. It shows remarkable homology to the mouse IL-10 promoter in regions that have been associated with transcriptional regulation, including a cAMP responsive element which could explain the cAMP-mediated effects. The lack of a NF-kappa B-like binding site in the human sequence suggests a NF-kappa B-independent mechanism of TNF-alpha-induced IL-10 gene activation.(ABSTRACT TRUNCATED AT 250 WORDS)
Longer peptide can be accommodated in the MHC class I binding site by a protrusion mechanism (2000)

According to current consensus, CD8(+) T cell responses are focused upon short peptide sequences (8-11 amino acids) presented by MHC class I molecules. This size restriction is thought to operate mostly at the level of peptide-MHC class I interaction. Crystal structures have shown that the free N and C termini of a bound peptide interact through hydrogen bonding networks to conserved residues at either end of the class I binding site. Accordingly, it is thought that the termini are fixed and that only minor variations in peptide size are possible through a central bulging mechanism. We find that this consensus view is not always correct as some peptide-MHC class I interaction will accept significant extensions. Furthermore, our results indicate that in some cases protrusion, rather than bulging, may be the mechanism of extension. Depending upon the particular peptide-MHC combination in question, such extensions can occur at either the N or C terminus (but never both at the same time). Finally, we show that MHC and T cell in some cases can detect the identity of the extension, i.e. that extensions may be part of the specificity of the T cell immune response. We suggest that such extensions may play a physiological role.
Copolymerisationen auf dem Anstrichmittel‐Gebiet III: Die Reaktion trocknender Öle mit Inden (1960)

Abstract Beim Erhitzen von Polyenölen mit Inden entstehen Copolymerisate, die nach Sikkativ‐Zusatz schnell trocknen und harte, elastische Filme von hohem Glanz ergeben. Anhand der Modellreaktion von Inden mit β‐Elaeostearinsäure‐methylester und durch die Isolierung einer definierten Verbindung aus dem Copolymerisat eines natürlichen Triglycerids und des Indens wird der Beweis erbracht, daß die Copolymerisation von Polyenölen mit Inden nach Diels‐Alder verläuft. Das Inden spielt hierbei die Rolle des dienophilen Partners.
Expression ofras, c-myc, and p53 proteins in cervical intraepithelial neoplasia (1998)

These results established the normal distribution and expression patterns of p53, p62myc, and p21ras within 395 cervical biopsy samples representing normal through CIN III histology. The expression of these proteins (e.g., staining intensity and layer of epithelium staining positive) is similar in normal tissues and those demonstrating all grades of CIN.
Chemopreventive activity of celecoxib, a specific cyclooxygenase‐2 inhibitor, and indomethacin against ultraviolet light–induced skin carcinogenesis (1999)

Epidemiological and dietary studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer, possibly through a mechanism involving inhibition of cyclooxygenase (COX)-2, which is overexpressed in premalignant adenomatous polyps and colon cancer. Because ultraviolet light (UV) can induce COX-2 and nonspecific NSAIDs can decrease UV-induced skin cancer, we evaluated the ability of two compounds, celecoxib (a specific COX-2 inhibitor) and indomethacin (a nonspecific NSAID), to block UV-induced skin tumor development in SKH:HR-1-hrBr hairless mice. Mice fed 150 or 500 ppm celecoxib showed a dose-dependent reduction (60% and 89%, respectively) in tumor yield. Indomethacin (4 ppm) reduced tumor yield by 78%. Although both acute and chronic UV exposure increased cell proliferation and edema, neither compound reduced these parameters. In contrast, UV-induced prostaglandin synthesis in the epidermis was effectively blocked by both compounds. UV-induced increases in COX-2 expression in skin were also not altered in any of the treatment groups. Similarly, tumors that constitutively express high levels of COX-2 displayed no reduction by treatment with celecoxib or indomethacin. The dramatic protective effects of celecoxib suggests that specific COX-2 inhibitors may offer a way to safely reduce the risk of skin cancer in humans. Mol. Carcinog. 25:231–240, 1999. © 1999 Wiley-Liss, Inc.
Experimental intracerebral hemorrhage: Description of a double injection model in rats (1996)

For experimental purposes, the most common technique of producing an intracerebral hematoma in rats is the injection of unclotted autologous blood. All modifications of this model share the problem that size and extension of the hematoma are not reproducible, because the injected blood either ruptures into the ventricular system or it extends to the subarachnoid or subdural space. Therefore a double injection model of experimental intracerebral hemorrhage in rats has been developed using 19 male Sprague-Dawley rats. After inducing anesthesia a cannula was stereotactically placed into the caudate nucleus and an intracerebral hematoma was produced with the double injection method in which first a small amount of fresh autologous blood is injected which is allowed to clot (preclotting) in order to block the way back along the needle track; the actual hematoma is produced in a second step of the injection. The clot volume was measured on stained serial sections. A total injection volume of 50 microliters of autologous blood produced intracerebral hematomas of 41.1 +/- 10.0 microliters and of similar shapes. The double injection method allows to generate reproducible hematomas in rats. This new model of intracerebral hemorrhage will allow further investigation of fibrinolytic and cytoprotective therapies.