gebhart/patrepeval huggingface dataset:
Interaction of cis platinum(II) compounds with poly(L-glutamate). A doubly anchored spin-label and a doubly anchored chromophore-label (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteraction of cis platinum(II) compounds with poly(L-glutamate). A doubly anchored spin-label and a doubly anchored chromophore-labelYen Yau H. Chao, Alfred Holtzer, and Stephen H. MastinCite this: J. Am. Chem. Soc. 1977, 99, 24, 8024–8032Publication Date (Print):November 1, 1977Publication History Published online1 May 2002Published inissue 1 November 1977https://pubs.acs.org/doi/10.1021/ja00466a041https://doi.org/10.1021/ja00466a041research-articleACS PublicationsRequest reuse permissionsArticle Views112Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Relationship Between Plasma Fibrinogen and Coronary Heart Disease in Women (1999)

Plasma fibrinogen is an independent risk factor for coronary heart disease (CHD) in men; however, its role in women is less clear. We examined the ability of plasma fibrinogen to predict CHD in a community-based, case-control study of women aged 65 years or younger living in the greater Stockholm area. Cases were all patients hospitalized for an acute coronary event between February 1991 and February 1994. Controls were randomly selected from the city census and were matched to cases by age and catchment area. Plasma fibrinogen was measured 3 to 6 months after hospitalization by using a fibrinogen assay based on fibrinogen polymerization time measurement. Of the 292 consecutive cases, 110 (37%) were hospitalized for an acute myocardial infarction and 182 (63%) for angina pectoris. The mean age+/-SD in both patients and controls was 56+/-7 years. Mean levels of plasma fibrinogen in patients and controls were 3.66+/-0.81 and 3.25+/-0.64 g/L (P<0.0001), respectively. The age-adjusted odds ratio (OR) for CHD in the highest versus the lowest quartile of plasma fibrinogen was 6.0 (95% confidence interval [CI], 3.5 to 10.4). After adjustment for age, cigarette smoking, body mass index, systolic blood pressure, total cholesterol, high density lipoprotein cholesterol, triglycerides, and educational level, the OR was 3.0 (95% CI, 1.6 to 5.5). Further adjustment for C-reactive protein yielded the same result. In both premenopausal and postmenopausal women, the multivariate-adjusted ORs were 7.0 (95% CI, 1.8 to 28.3) and 2.1 (95% CI, 1.0 to 4.4), respectively. These results provide evidence that plasma fibrinogen is associated with an excess risk of CHD in women.
SUPPLY MODELS FOR USE IN MODELING THE VARIABILITY OF JOURNEY TIMES ON THE HIGHWAY NETWORK (2002)

This paper describes how there is an evident desire to include measure of reliability in transport modeling and evaluation procedures. Volume 2 of the UK Department for Transport's (DfT) Guidance on the Methodology for the Multi-Modal Studies includes Reliability as sub-objective under Economy, and implies that some measure of reliability, such as the standard deviation of the travel time distribution could be included in the utility (or generalized cost) of travel alternatives. However, for road travel, GOMMMS recognizes that may not always be possible to derive monetized benefit value. Specifically, distinction is made between travel time variability because of incidents ant that due to a high level of day to day variability, and GOMMMS suggests that for the latter the methodology is still under development. Moreover the monetisation itself may be considered lesser problem. In order to use these results it is necessary to be able to specify how transport intervention will affect public transport lateness and/or private vehicle travel time variability.
Using collaborative robots to assist with travel path development for material deposition based additive manufacturing processes (2018)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
Lysine is a common determinant for mannose phosphorylation of lysosomal proteins. (1994)

The phosphorylation of lysosomal enzymes on high mannose residues is the first step in the targeting of these enzymes to lysosomes in a wide range of mammalian cells. Phosphorylated lysosomal enzymes bind to mannose 6-phosphate receptors, which divert them from the secretory pathway and direct them toward the lysosome. We have been investigating the basis for the specific recognition of lysosomal enzymes by UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase by using the precursor form of the lysosomal cysteine protease, cathepsin L, as a model lysosomal enzyme in an in vitro assay for mannose phosphorylation. Cathepsin L was found to be phosphorylated in vitro with the same efficiency as other lysosomal enzymes and to contain a conformationally sensitive protein signal that is recognized by phosphotransferase. Biochemical modification of lysine residues on cathepsin L with sulfo-N-hydroxysuccinimide acetate prevented the enzyme from being phosphorylated, indicating that lysine is an important component of the signal. The modification itself did not cause any major conformational changes in cathepsin L. When the same modification was performed on a number of other lysosomal enzymes, phosphorylation was also inhibited. Thus, we conclude that lysine residues are important features of lysosomal enzyme phosphotransferase recognition sites in general, and we discuss the implications of this finding in the ongoing efforts to define the phosphotransferase recognition site.
원저 : 녹용약침액이 생쥐의 Type 2 collagen 유발 관절염과 인산이온 유발 연골세포의 세포사에 있어 보호작용에 관한 연구 (2002)

연구목적 : 면역억제와 활성 작용을 지닌 것으로 알려진 녹용약침(CPH)을 typeⅡ collagen 유발 관절염 (CIA) 백서와 인산이온 유발 연골세포의 세포사에 있어 보호활성 효과를 연구하였다.
연구방법 : 7주된 암컷 Sprague-Dawley 쥐를 collagen으로 관절염을 유발시킨 후 CPH의 효과를 관절염 점수, 체중감소 등의 평가기준으로 검정하였다. CPH는 일주일에 5번씩 각각 10, 20, 30 및 100㎍/㎏/day의 용량으로 양측 신수혈에 주입하였다.
연구결과 : 
1. 300 ㎎/㎏/day CPH처리로 관절염점수의 감소를 기초로 한 collagen 유발 관절염의 발생을 완전히 억제하였으며 관절염 점수상에서 CPH의 효과작인 용량은 64 ㎎/㎏이었다.
2. CHP는 쥐의 간에 있는 DHO-DHase 활성을 Ki=843±43㎍/ml의 비교적 높은 비활성으로 억제하였다.
3. 관절염관련 세포의 증식억제활성을 검정한 결과 CPH의 항 증식효과는 세포주기 S기에서 정지시키는 활성을 나타내었다.
4. 쥐의 늑연골로부터 완전히 최종 분화된 비대연골세포를 분리 배양하여 3∼5mM/L Pi를 첨가함으로서 세포사멸을 측정하였다. 10㎍/ml CPH 처리에 의한 보호(억제) 효과가 Pi-유발 연골세포의 세포사에 대한 Na-Pi cotransport의 경쟁적 저해제로 알려진 phosphonoformic acid(PFA)의 억제활성과 상응하는 수준으로 CPH의 활성을 확인하게 되었다
Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function (1997)

Allogeneic bone marrow transplant recipients often exhibit a graft-versus-host-disease (GVHD)-associated immune deficiency that can be prolonged and lead to life-threatening infections. We have examined the role of donor T cell-mediated cytotoxic function in the development of GVHD-associated immune deficiency. A major histocompatibility complex-matched model of allogeneic bone marrow transplantation was employed in which lethally irradiated C3H.SW mice received a nonlethal dose of T cells from either perforin-deficient (B6-perforin 0/0), Fas-ligand (FasL)-defective (B6-gld), or normal (B6) allogeneic donor mice. T cell-depleted marrow from B6-Ly-5.1 congenic donor mice was transplanted along with the donor T cell populations to determine the effects of donor T cell-mediated cytotoxicity on engraftment. Our results demonstrate that recipients of perforin-deficient or normal allogeneic T cells exhibit profound lymphoid hypoplasia and severely reduced splenic proliferative responses to lipopolysaccharide in vitro. In contrast, GVHD-associated lymphoid hypoplasia is dramatically reduced and in vitro B cell function is intact in recipients of FasL-defective allogeneic T cells. Engraftment of myeloid and erythroid lineage cells occurs irrespective of donor T cell cytotoxic function. Although recipients of perforin-deficient or normal allogeneic T cells exhibited hematopoietic engraftment exclusively of donor origin, recipients of FasL-defective donor T cells exhibited significant mixed chimerism (Ly-5.1/Ly-5.2). Because only marrow of donor origin was transplanted, this finding suggests that Fas-mediated antirecipient cytotoxicity is required for clearance of residual hematopoietic stem cells of host origin that persist following lethal irradiation.
Centerline-based colon segmentation for CAD of CT colonography (2006)

We developed a fast centerline-based segmentation (CBS) algorithm for the extraction of colon in computer-aided detection (CAD) for CT colonography (CTC). CBS calculates local centerpoints along thresholded components of abdominal air, and connects the centerpoints iteratively to yield a colon centerline. A thick region encompassing the colonic wall is extracted by use of region-growing around the centerline. The resulting colonic wall is employed in our CAD scheme for the detection of polyps, in which polyps are detected within the wall by use of volumetric shape features. False-positive detections are reduced by use of a Bayesian neural network. The colon extraction accuracy of CBS was evaluated by use of 38 clinical CTC scans representing various preparation conditions. On average, CBS covered more than 96% of the visible region of colon with less than 1% extracolonic components in the extracted region. The polyp detection performance of the CAD scheme was evaluated by use of 121 clinical cases with 42 colonoscopy-confirmed polyps 5-25 mm. At a 93% by-polyp detection sensitivity for polyps ≥5 mm, a leave-one-patient-out evaluation yielded 1.4 false-positive polyp detections per CT scan.
A Novel Differentiated Marking Strategy based on Explicit Congestion Notification for Wireless TCP (2006)

TCP (transmission control protocol) has extended its reach to the wireless realm in that it has also been used widely in all sorts of wireless environments. However, the congestion control approaches designed for wired TCP or even some wireless situations are not effective enough. We propose a new explicit congestion control (ECN) strategy-differentiated marking, which works by using a two-way approach to further reduce the time required for the sender and the receiver to note the congestion problem, possibly induced by too heavy traffic or burst errors caused by the time-varying channel quality
Cyclic AMP Response Element-Binding Protein Overexpression: A Feature Associated with Negative Prognosis in Never Smokers with Non–Small Cell Lung Cancer (2008)

Lung cancer is the leading cause of cancer deaths worldwide. Recent advances in targeted therapies hold promise for the development of new treatments for certain subsets of cancer patients by targeting specific signaling molecule. Based on the identification of the transcription factor cyclic AMP response element-binding protein (CREB) as an important regulator of growth of several types of cancers and our recent findings of its importance in normal differentiation of bronchial epithelial cells, we hypothesized that CREB plays an important pathobiologic role in lung carcinogenesis. We conducted this initial study to determine whether the expression and activation status of CREB are altered in non-small cell lung cancer (NSCLC) and of any prognostic importance in NSCLC patients. We found that the expression levels of mRNA and protein of CREB and phosphorylated CREB (p-CREB) were significantly higher in most of the NSCLC cell lines and tumor specimens than in the normal human tracheobronchial epithelial cells and adjacent normal lung tissue, respectively. Analysis of CREB mRNA expression and the CREB gene copy number showed that CREB overexpression occurred mainly at the transcriptional level. Immunohistochemical analysis of tissue microarray slides containing sections of NSCLC specimens obtained from 310 patients showed that a decreased survival duration was significantly associated with overexpression of CREB or p-CREB in never smokers but not in current or former smokers with NSCLC. These are the first reported results illustrating the potential of CREB as a molecular target for the prevention and treatment of NSCLC, especially in never smokers.
Polyacrylate emulsion containing IBOMA for removable pressure sensitive adhesives (2015)

ABSTRACT In the area of pressure sensitive adhesives (PSAs), corona treatment or other preprocessing on the carrier was commonly utilized for the enhancement of the interaction between the adhesive layer and the carrier, with complicated procedures and operations. To make it easy, one‐pot emulsion polymerization using n‐butyl acrylate, isobornyl methacrylate (IBOMA), 2‐hydroxyethyl acrylate and acrylic acid was conducted in the presence of a reactive emulsifier SR‐20 to obtain a reinforced adhesive tape. First, the emulsion had good stabilities, especially freeze‐thaw stability, which was helpful to the fabrication of PSAs. Second, IBOMA increased the binding strength between adhesive layer and adherend. The properties of the final tapes well fulfilled the requirements of this areas, such as that the 180° peel strength of 125.9 N/m when coated on non‐corona surfaces, the tack of 19 #, and the shear holding time of more than 100 h. Third, the tapes produced using the above emulsion could be removed many times, with no PSAs residue on the adherend even when coated on untreated PP, which showed the potential of recycling and environmental protection. Thus, these properties make the polyacrylate emulsion have great potential for practical applications. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 42886.
Growth factors for human fibroblasts in the solute remaining after clot formation (1990)

Fibroblasts adhere to, and readily grow into, fibrin clots that form as a result of the cleavage of fibrinogen by thrombin. Subsequent fibroblast replication is believed to be stimulated by mitogens released by entrapped platelets, such as platelet-derived growth factor. We suggest that the supernatant remaining after the fibrinogen-thrombin reaction could stimulate fibroblast replication, even in the absence of other blood components. To examine this hypothesis we expressed liquid from a fibrin clot and measured its mitogenic activity on human lung fibroblasts, in serum-free conditions, using a colorimetric assay based on uptake and subsequent release of Methylene Blue. The clot supernatant caused a mitogenic response of 51 +/- 6% above control and was equivalent to about half that elicited by medium containing 10% newborn calf serum. On their own, both thrombin and fibrinopeptides A and B (small molecular weight cleavage products released from fibrinogen) showed some mitogenic activity, but there was also activity in higher molecular weight cleavage products, suggesting the presence of uncharacterized mitogens. It is proposed that these agents may play important roles in wound healing and diseases associated with vascular leakage and fibrosis, by stimulating fibroblast replication.
Dynamic Control of Deactivation Gating by a Soluble Amino-Terminal Domain in <i>HERG</i> K+ Channels (2000)

K(+) channels encoded by the human ether-à-go-go-related gene (HERG) are distinguished from most other voltage-gated K(+) channels by an unusually slow deactivation process that enables cardiac I(Kr), the corresponding current in ventricular cells, to contribute to the repolarization of the action potential. When the first 16 amino acids are deleted from the amino terminus of HERG, the deactivation rate is much faster (Wang, J., M.C. Trudeau, A.M. Zappia, and G.A. Robertson. 1998. J. Gen. Physiol. 112:637-647). In this study, we determined whether the first 16 amino acids comprise a functional domain capable of slowing deactivation. We also tested whether this "deactivation subdomain" slows deactivation directly by affecting channel open times or indirectly by a blocking mechanism. Using inside-out macropatches excised from Xenopus oocytes, we found that a peptide corresponding to the first 16 amino acids of HERG is sufficient to reconstitute slow deactivation to channels lacking the amino terminus. The peptide acts as a soluble domain in a rapid and readily reversible manner, reflecting a more dynamic regulation of deactivation than the slow modification observed in a previous study with a larger amino-terminal peptide fragment (Morais Cabral, J.H., A. Lee, S.L. Cohen, B.T. Chait, M. Li, and R. Mackinnon. 1998. Cell. 95:649-655). The slowing of deactivation by the peptide occurs in a dose-dependent manner, with a Hill coefficient that implies the cooperative action of at least three peptides per channel. Unlike internal TEA, which slows deactivation indirectly by blocking the channels, the peptide does not reduce current amplitude. Nor does the amino terminus interfere with the blocking effect of TEA, indicating that the amino terminus binding site is spatially distinct from the TEA binding site. Analysis of the single channel activity in cell-attached patches shows that the amino terminus significantly increases channel mean open time with no alteration of the mean closed time or the addition of nonconducting states expected from a pore block mechanism. We propose that the four amino-terminal deactivation subdomains of the tetrameric channel interact with binding sites uncovered by channel opening to specifically stabilize the open state and thus slow channel closing.
Comparison of variations in MOSFET versus CNFET in gigascale integrated systems (2012)

Using previously developed model for CNT density variation in CNFETs and random dopant fluctuation model in MOSFET, we compared and presented overall device variations in MOSFET and CNFET for gigascale integrated systems. Even if all of the sources of variation can be well-controlled in the manufacturing process, it is very hard (if not impractical) to control the dopant fluctuation in MOSFET and CNT density variation in CNFET device technology. Our analysis shows that in 32nm technology node, the random dopant fluctuation in a typical n-type MOSFET creates 1.1% on-current, 6.7% off-current, 0.23% input capacitance, and 1.6% threshold voltage variations, while the CNT density variation in a typical n-type CNFET with 10 CNTs in the channel creates 23% on-current, 22% off-current, 23% gate capacitance and only 0.011% threshold voltage variations. Based on our analysis, although the threshold voltage variation in CNFET is very small, the overall variations in CNFETs are worse than the variations in MOSFETs. As a result CNT density variation in CNFETs must be carefully taken into account for current gigascale and future terascale integrated systems.
High level expression in Escherichia coli of a fungal gene under the control of strong promoters (1990)

A recent report (Patino et al., (1989) FEMS Microbiol. Lett. 58, 139-144) described the low level expression, in Escherichia coli, of the Isopenicillin N Synthase (IPNS) gene from Cephalosporium acremonium under the control of strong promoters. We report here our work on the expression of the IPNS gene. Plasmids containing the IPNS gene under the control of the trp or trc promoters directed synthesis of high levels of active IPNS in E. coli. Constitutive and inductive high level IPNS expression systems have been developed. Importantly, the expression vectors do not encode beta-lactamase so IPNS activity can be determined directly by biological assays. Analysis by nmr verified that the IPNS produced from these expression systems catalysed the conversion of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine (LLD-ACV) to isopenicillin N in high yield.
Simultaneous 3-D Imaging Using Chirped Ultrashort Optical Pulses (1994)

A novel method for simultaneous 3-D imaging using chirped ultrashort light pulses is proposed. Simultaneous imaging without scanning is possible by means of the conversion between the time and the color axes mediated by the chirped pulse. The theoretical limitation of the spatial resolution is discussed. We proved the efficacy of this method by measuring an area composing three flat steps made of three gauge blocks of different lengths with an accuracy of better than 0.3 mm. This technique is applicable for imaging of the shape of moving objects, or surface testing or inspection.
<b>A geoid for the</b> Australian capital territory (1997)

Abstract AUSGEOID93 is a national grid of geoid-ellipsoid separations (N values). When differences in N from AUSGEOID93 are subtracted from differences in ellipsoidal height from GPS surveys, the resulting differences in orthometric height frequently approach 3rd Order levelling accuracy. However, in areas of rapid changing terrain, the results may be less accurate. It was believed that this was due to the absence of terrain data in AUSGEOID93. The ACT region was chosen to test this hypothesis and at the same time produce a grid of improved N values approximately 4 times denser than AUSGEOID93.
Crystallographic studies of the activity of hen egg-white lysozyme (1967)

Abstract The chemical evidence for the enzymic activity of lysozyme will be discussed in detail by other speakers at this meeting, but in order to describe our crystallographic studies of the interactions between the enzyme and its substrates it is necessary to summarize briefly what was known about them at the beginning of our work. Simultaneously with his discovery of lysozyme Fleming (1922) discovered a Gram-positive species of bacteria, Micrococcus lysodeikticus, which is particularly susceptible to the action of the enzyme. It was not until much later, however, that Salton (1952) demonstrated that the substrate is located entirely within the bacterial cell wall and it is only very recently that its chemical constitution has been established. Valuable early experiments (for example, by Meyer, Palmer, Thomson & Khorazo 1936; Meyer, Hahnel & Steinberg 1946; and by Epstein & Chain 1940) showed that lysozyme releases N-acetyl-amino sugars from M. lysodeikticus, but the first indication of the type of linkage attacked by lysozyme came when Berger & Weiser (1957) showed that lysozyme also degrades chitin, the linear polymer of N-acetylghicosamine.