gebhart/patrepeval huggingface dataset:
Retinal Pigment Epithelial Cell Behavior is Modulated by Alterations in Focal Cell–Substrate Contacts (2004)

Disturbed focal contact in ARPE-19 cells grown on micropatterned surfaces altered cell cycle, growth, morphology, and the expression of IL-6 in vitro.
Path planning and integrated collision avoidance for autonomous vehicles (2017)

This paper discusses some of the current state-of-the-art and remaining challenges in research on path planning and vehicle control of autonomous vehicles. Reliable path planning is fundamental for the proper operation of an autonomous vehicle. Typically, the path planner relies on an incomplete model of the surroundings to generate a reference trajectory, used as input to a vehicle controller that tracks this reference trajectory. Depending on how much complexity is put into the path-planning block, the path planning and vehicle-control blocks can be viewed as independent of each other, connected to each other, or merged into one block. There are several types of path-planning techniques developed over the last decades, each with its own set of benefits and drawbacks. We review different techniques for path planning and trajectory tracking, and give examples of its use in relation to autonomous vehicles. We report on our own recent findings and give an outlook on potential research directions.
Overview of Intelligent Power Controller Development for the Deep Space Gateway (2017)

Intelligent, or autonomous, control of a spacecraft is an enabling technology that must be developed for deep space human exploration. NASAs current long term human space platform, the International Space Station, which is in Low Earth Orbit, is in almost continuous communication with ground based mission control. This allows near real-time control of all the vehicle core systems, including power, to be controlled by the ground. As focus shifts from Low Earth Orbit, communication time-lag and communication bandwidth limitations beyond geosynchronous orbit does not permit this type of operation. This presentation contains ongoing work at NASA to develop an architecture for autonomous power control and the vehicle manager which monitors, coordinates, and delegates to all the on-board subsystems to enable autonomous control of the complete spacecraft.
Show Me Microsoft Office Outlook 2003 (2003)

See it done, do it yourself! Spend less time reading and more time doing with this simple, step-by-step approach. Outlook 2003, the most changed application in this revision of Office, provides powerful new tools with which to get connected, manage information, and communicate with others. Based on a proven, successful series format, this book uses a visual page design with easy-to-read text to teach beginning to intermediate level Outlook tasks. Troubleshooting guides, see also referencing, sample projects, and MOS objectives add even more for the ambitious learner. Author Steve Johnson is a professional trainer and author of several best-selling books.
Scavenger Receptor BI (SR-BI) Is Up-regulated in Adrenal Gland in Apolipoprotein A-I and Hepatic Lipase Knock-out Mice as a Response to Depletion of Cholesterol Stores (1996)

Scavenger receptor BI (SR-BI), a putative high density lipoprotein (HDL) receptor, mediates the selective uptake of HDL cholesteryl ester into cells and is highly expressed in adrenal gland (Acton, S., Rigotti, A., Landschulz, K.T., Xu, S., Hobbs, H.H., and Krieger, M. (1996) Science 271, 518-520). Apolipoprotein A-I knock-out (apoA-I0) mice have decreased HDL cholesterol, depleted adrenal cholesterol stores and impaired corticosteroid synthesis (Plump, A.S., Erickson, S.K., Weng, W., J. Clin. Invest. 97, 2660-2671). We now show up-regulation of adrenal SR-BI mRNA and protein in apoA-I0 mice, but not in apoA-II0, LDL receptor 0, apoE0, or cholesteryl ester transfer protein transgenic mice. Adrenal SR-BI mRNA and protein are also increased and cholesterol stores decreased in female mice with knockout of hepatic lipase, and enzyme previously shown to increase selective uptake in cell culture. SR-BI mRNA is increased in stressed wild type mice and in Y1 adrenal cells treated with adrenocorticotropic hormone; the latter effect is inhibited by HDL. These findings provide in vivo evidence showing SR-BI is a functional HDL receptor under feedback control. The action of hepatic lipase on apoA-I-containing lipoproteins may facilitate the SR-BI-mediated uptake of HDL lipid.
Recent developments in coffee roasting technology. (2005)

Therefore, a concept for the mechanism of volume expansion was developed. During roasting, structural cell wall polymers such as mannan, arabinogalactan and cellulose are changing to a rubbery state allowing limited changes in volume, but preventing the beans from disintegration. From DMTA data, a state diagram of cell wall polymers and coffee beans was developed and the conditions for an elastic behaviour allowing volume expansion were identified.
BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin β1 (2007)

Glycosylation of beta1 integrin (beta1) in the Golgi complex has been related to its function in multiple cell processes, e.g., invasiveness, matrix adhesion, and migration. Brefeldin A-inhibited guanine nucleotide-exchange proteins (BIG) 1 and BIG2 activate human ADP-ribosylation factors (ARF) 1 and ARF3 by catalyzing the replacement of ARF-bound GDP with GTP to regulate Golgi vesicular transport. We show here a requirement for BIG1 (but not BIG2) in glycosylation and function of beta1. In HepG2 cells treated for 48 or 72 h with BIG1, but not BIG2, siRNA, both the amount and electrophoretic mobility of the initially 130-kDa beta1 were increased. BIG1 content had risen by 48 h after removal of BIG1 siRNA, and the faster-migrating, aberrant 130-kDa beta1 was not seen. Peptide N-glycosidase F, but not endoglycosidase H, digestion converted all beta1 to an approximately 85-kDa (core protein) form. By electron microscopy, Golgi membranes in BIG1-depleted cells were less sharply defined than those in mock or BIG2 siRNA-treated cells, with more vesicle-like structures at the transface. Amounts of active RhoA-GTP also were decreased in such cells and restored by overexpression of HA-BIG1. Aberrant beta1 was present on the cell surface, but its function in cell spreading, adhesion, and migration was impaired. By immunofluorescence microscopy, BIG1 siRNA-treated cells showed less spreading and concentration of beta1 at the cell surface. These results indicate a previously unrecognized role for BIG1 in the glycosylation of beta1 by Golgi enzymes, which is critical for its function in developmental and other vital cell processes.
Toward athermal silicon-on-insulator (de)multiplexers in the O-band (2015)

We report on the design, fabrication, and characterization of a 1×4 silicon-on-insulator (SOI) demultiplexer exhibiting a significant reduction of its thermo-optical sensitivity in the O-band. The optical filtering is achieved by cascading several Mach-Zehnder interferometers (MZIs) fabricated on a 300-nm-thick SOI platform. Owing to an asymmetric design of the confinement for each MZIs, we found an athermal criterium that satisfies the spectral requirements. The thermal sensitivity of the structure is analyzed by a semi-analytical model in order to create an athermal multiplexer. Fiber-to-fiber thermo-optical testing reveals a thermal sensitivity of around 17 pm/°C reduced by 75% compared to the standard devices with promising performances for both the crosstalk (15 dB), the insertion losses (4 dB), and absolute lambda registration (<0.25 nm).
3-D cellular systems for air-land communications (2002)

In VHF air/ground communication systems, the radio-line-of-sight (RLOS) between a ground station and an aircraft must exist. An aircraft at a certain altitude may be interfered by those signals from an over-horizontal stations using the same frequency band. A simple frequency management method is proposed to solve this problem and to get the efficient frequency-reuse to alleviate the frequency congestion in the air traffic control (ATC), flight services and mobile communication services. The authors apply the concept of the terrestrial mobile cellular system to design the 3D cellular system and find the capacities of systems with different access schemes, such as FDMA (interference free), TDMA, and CDMA.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
X-ray photoelectron spectroscopic studies of sulfates and bisulfates interpreted by X? and band structure calculations (2000)

Valence-band and core-level x-ray photoelectron spectroscopy (XPS) studies of sulfate and bisulfate ions are reported. Sulfate and bisulfate ions cannot be distinguished in their core XPS spectra. The valence band region shows a significant difference in the relative intensity and separation of two prominent peaks, and this difference can be used to distinguish between sulfate and bisulfate because the separation is larger in the case of sulfate (∼4 eV) than for bisulfates (∼3 eV). We show that this difference can be used in a wide range of sulfate and bisulfates, including main group and transition metal compounds: Li2SO4, Na2SO4, K2SO4, MgSO4, Al2(SO4)3, Fe2(SO4)3, FeSO4, Ni2SO4, Ag2SO4, (NH4)2SO4, NaHSO4, KHSO4 and NH4HSO4 (some of these are hydrated). The sulfate and bisulfate spectra can be interpreted by cluster (multiple scattered-wave Xα calculations) and band structure calculations. A careful analysis of the valence band spectra of Li2SO4H2O interpreted by band structure calculation results shows that the water of crystallization can be identified in the valence band region. Copyright © 2000 John Wiley & Sons, Ltd.
The<scp>B</scp>ravyi–<scp>K</scp>itaev transformation: Properties and applications (2015)

Quantum chemistry is an important area of application for quantum computation. In particular, quantum algorithms applied to the electronic structure problem promise exact, efficient methods for determination of the electronic energy of atoms and molecules. The Bravyi–Kitaev transformation is a method of mapping the occupation state of a fermionic system onto qubits. This transformation maps the Hamiltonian of n interacting fermions to an ‐local Hamiltonian of n qubits. This is an improvement in locality over the Jordan–Wigner transformation, which results in an O ( n )‐local qubit Hamiltonian. We present the Bravyi–Kitaev transformation in detail, introducing the sets of qubits which must be acted on to change occupancy and parity of states in the occupation number basis. We give recursive definitions of these sets and of the transformation and inverse transformation matrices, which relate the occupation number basis and the Bravyi–Kitaev basis. We then compare the use of the Jordan–Wigner and Bravyi–Kitaev Hamiltonians for the quantum simulation of methane using the STO‐6G basis. © 2015 Wiley Periodicals, Inc.
Server virtualization in autonomic management of heterogeneous workloads (2008)

Server virtualization opens up a range of new possibilities for autonomic datacenter management, through the availability of new automation mechanisms that can be exploited to control and monitor tasks running within virtual machines. This facilitates more powerful and flexible autonomic controls, through management software that maintains the system in a desired state in the face of changing workload and demand. This paper explores in particular the use of server virtualization technology in the autonomic management of data centers running a heterogeneous mix of workloads. We present a system that manages heterogeneous workloads to their performance goals and demonstrate its effectiveness via real-system experiments and simulation.
Indirect dc-link voltage control of two-stage single-phase PV inverter (2009)

This paper presents a novel indirect dc-link voltage control scheme for the application of grid-tied two-stage single-phase photovoltaic conversion system. Unlike the traditional control method for grid-tied inverters where the dc-link voltage is always directly sensed to regulate the output current, the proposed scheme eliminates the dc-link voltage sensing unit but does not downgrade the inverter overall performance. The proposed scheme can be easily extended to control the multi-string configuration without any extra control complexity needed. Simulation verifications prove the effectiveness of the proposed control scheme.
Modulation of metastatic potential of B16F10 melanoma cells by acivicin: synergistic action of glutaminase and potentiation of cisplatin cytotoxicity. (2008)

Treatment for metastatic melanoma has mostly been unsatisfactory despite advances in ongoing medical research. Here we investigated the role of acivicin, a glutamine analogue, singly and in combination with either E. coli glutaminase or cisplatin, on the growth, angiogenic activity and invasiveness of B16F10 cells in vitro and after allografting in C57BL/6 mice. B16F10 melanoma colonization in the lungs of mice was measured by monitoring colony counts. Host toxicity was assessed with reference to tumor bearing host's weight and survivability. Acivicin promoted melanoma dormancy and reduced melanoma associated angiogenic factors like VEGF level and vessel diameter. Acivicin in combination with glutaminase significantly suppressed tumor growth by 66.7% and increased life-span by 43.5% without host toxicity. Tumor VEGF content was significantly lowered by combination therapy as assessed by ELISA. Accelerated cytotoxicity, reduced invasion and enhanced apoptosis of melanoma cells were exhibited in vitro by combined than by single agent treatment. Moreover, invasion of melanoma cells through matrigel chambers was reduced in presence of acivicin and glutaminase combination. These findings support future studies of acivicin in combination with other anticancer agents for prevention of melanoma metastasis.
Constrained Dix inversion (2006)

Abstract We propose a stable inversion method to create geologically constrained instantaneous velocities from a set of sparse, irregularly picked stacking- or rms-velocity functions in vertical time. The method is primarily designed for building initial velocity models for curved-ray time migration and initial macromodels for depth migration and tomography. It is mainly applicable in regions containing compacted sediments, in which the velocity gradually increases with depth and can be laterally varying. Inversion is done in four stages: establishing a global initial background-velocity trend, applying an explicit unconstrained inversion, performing a constrained least-squares inversion, and finally, fine gridding. The method can be applied to create a new velocity field (create mode) or to update an existing one (update mode). In the create mode, initially, the velocity trend is assumed an exponential, asymptotically bounded function, defined locally by three parameters at each lateral node and calculated from a reference datum surface. Velocity picks related to nonsediment rocks, such as salt flanks or basalt boundaries, require different trend functions and therefore are treated differently. In the update mode, the velocity trend is a background-velocity field, normally used for time or depth imaging. The unconstrained inversion results in a piecewise-constant, residual instantaneous velocity with respect to the velocity trend and is mainly used for regularizing the input data. The constrained inversion is performed individually for each rms-velocity function in vertical time, and the lateral and vertical continuities are controlled by the global velocity-trend function. A special damping technique suppresses vertical oscillations of the results. Finally, smoothing and gridding (interpolation) are done for the resulting instantaneous velocity to generate a regular, fine grid in space and time. This method leads to a stable and geologically plausible velocity model, even in cases of noisy input rms-velocity or residual rms-velocity data.
Occurrence and Inhibition of Large Yawing Moments during High-Incidence Flight of Slender Missile Configurations (1973)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
MULTIFREQUENCY ANALOG FAULT DIAGNOSIS FOR LINEARIZED CIRCUITS (1983)

This report addresses the problem of multifrequency fault diagnosis performed in the context of the component connection model (CCM). The discussion includes an introduction to the CCM as well as two approaches to the fault diagnosis problem, the transfer function matrix approach and the tableau approach. The first method generates the fault diagnosis equations by equating measurement data expressed in terms of a composite system transfer matrix whose structure is delineated in terms of the CCM matrices. The resulting equations are extremely nonlinear and lack the lucidity that is characteristic of problems posed in terms of the CCM. The equations of the tableau approach on the other hand result from a characterization of the ambiguity associated with the measurement data. Such a characterization allows the fault diagnosis equations to remain in tableau form, thereby retaining the clarity and numerical stability usually associated with the use of the CCM. Basic properties of tableau approach presented include the formulation of a diagnosability test and upper/lower bounds on the number of test frequencies necessary to conduct a diagnosis. In addition to the full diagnosability problem this report also investigates the properties of the tableau fault diagnosis equations under the assumption that the number of simultaneous faults in a system under test is limited. The approach employs multifrequency testing to extract a maximum of information from a given set of test points. The analysis specifically addresses the case in which the number of faulty components exceeds the number of measurement points. The development includes a detailed description of the solution algorithm and example problems. A discussion of the test frequency and test point selection problems is also included.
The principles and practice of the gravity gradiometer (1932)

A description is given of the conditions in practical prospecting calling for a more portable, and rapid-acting gravity balance and leading up to the design of the gravity gradiometer. The dynamics of the suspended system of a gravity balance are investigated and the dynamical characteristics of the gradiometer indicated. A detailed description of the original instrument follows, with particulars of improvements incorporated in the latest pattern. Finally, a review of the field performance, as regards sensitivity and accuracy, of the gradiometer is given, with an account of a comparative test made on it in conjunction with a standard type of torsion balance. The gradiometer is shown to be a great improvement in the direction of portability and rapidity of action, and the design entails very little sacrifice of sensitivity. The latest pattern can be made five times as sensitive as the earlier model, without diminution of the rapidity of action.
Glutathione and HIV infection: reduced reduced, or increased oxidized? (1998)

Glutathione is the main intracellular defence against oxidative stress and regulates the cellular redox potential. HIV infection is accompanied by severe metabolic and immune dysfunctions. Several laboratories have demonstrated that the intracellular redox balance is disturbed in CD4+ T cells from HIV-seropositive subjects, which may potentiate HIV replication and partly explain the immunological abnormalities associated with HIV disease. The importance of glutathione for immune function, regulation of gene expression, as well as therapeutic interventions with redox-active drugs are discussed in this commentary.
Lysozyme Separation from Tobacco Extract by Aqueous Two-Phase Extraction (2003)

Tobacco has long been considered as a host to produce large quantities of high-valued recombinant proteins. However, dealing with large quantities of biomass with a dilute concentration of product is a challenge for down-stream processing. Aqueous two-phase extraction (ATPE) has been used in purifying proteins from various sources. It is a protein-friendly process and can be scaled up easily. ATPE was studied for its applicability to recombinant protein purification from tobacco using egg white lysozyme as the model protein. Separate experiments with polyethyleneglycol(PEG)/salt/tobacco extract, and PEG/salt/lysozyme were carried out to determine the partition behavior of tobacco protein and lysozyme, respectively. Two level fractional factorial designs were used to study the effects of factors such as PEG molecular weight, PEG concentration, the concentration of phase forming salt, sodium chloride concentration, and pH on protein partitioning. The results showed that PEG/sodium sulfate system was most suitable for lysozyme purification. Detailed experiments were conducted by spiking lysozyme into the tobacco extract. The conditions with highest selectivity of lysozyme over native tobacco protein were determined using a response surface design. The purification factor was further improved by decreasing the phase ratio along the tie line corresponding to the phase compositions with the highest selectivity. Under selected conditions the lysozyme yield was predicted to be 87% with a purification factor of 4 and concentration factor of 14. The binodial curve and tie line corresponding to the optimal condition for lysozyme recovery for the PEG 3400/sodium sulfate system were developed. The selectivity at the optimal condition was experimentally determined to be 47 with a lysozyme yield of 79.6 % with a purification factor of 10 and a concentration factor of 20. From this study, ATPE was shown to be suitable for initial protein recovery and partial purification from transgenic tobacco.
BET Family Protein BRD4: An Emerging Actor in NFκB Signaling in Inflammation and Cancer (2018)

NFκB (Nuclear Factor-<i>κ</i>-light-chain-enhancer of activated B cells) signaling elicits global transcriptional changes by activating cognate promoters and through genome-wide remodeling of cognate regulatory elements called "super enhancers". BET (Bromodomain and Extra-Terminal domain) protein family inhibitor studies have implicated BET protein member BRD4 and possibly other BET proteins in NFκB-dependent promoter and super-enhancer modulation. Members of the BET protein family are known to bind acetylated chromatin to facilitate access by transcriptional regulators to chromatin, as well as to assist the activity of transcription elongation complexes via CDK9/pTEFb. BET family member BRD4 has been shown to bind non-histone proteins and modulate their activity. One such protein is RELA, the NFκB co-activator. Specifically, BRD4 binds acetylated RELA, which increases its transcriptional transactivation activity and stability in the nucleus. In aggregate, this establishes an intimate link between NFκB and BET signaling, at least via BRD4. The present review provides a brief overview of the structure and function of BET family proteins and then examines the connections between NFκB and BRD4 signaling, using the inflammatory response and cancer cell signaling as study models. We also discuss the potential of BET inhibitors for relief of aberrant NFκB signaling in cancer, focusing on non-histone, acetyl-lysine binding functions.