gebhart/patrepeval huggingface dataset:
Binding and endocytosis of apo- and holo-lactoferrin by isolated rat hepatocytes. (1991)

We characterized binding and endocytosis of 125I-bovine lactoferrin by isolated rat hepatocytes. Iron-depleted (apo-Lf), approximately 30% saturated (Lf), and iron-saturated (holo-Lf) lactoferrin were used. At 4 degrees C, cells bound 125I-apo-Lf and 125I-holo-Lf with nearly identical apparent first order kinetics (t1/2 = approximately 42 min). Holo-Lf and apo-Lf competed with each other for binding. Hepatocytes bound lactoferrin optimally at pH greater than or equal to 7 but poorly at pH less than or equal to 6. Ca2+ (greater than or equal to 100 microM) enhanced Lf binding to cells, and holo-Lf remained monomeric with Ca2+ present as determined by gel filtration chromatography. With Ca2+, cells exhibited approximately 10(6) high affinity sites (Kd approximately 20 nM) and approximately 10(7) low affinity sites (Kd approximately 700 nM) for both apo- and holo-Lf. Without Ca2+, cells bound 125I-holo-Lf by the low affinity component only. EGTA and dextran sulfate together released greater than or equal to 90% 125I-Lf prebound at 4 degrees C, but individually removed separate populations of surface-bound 125I-Lf. Cells bound 125I-Lf in a Ca(2+)-dependent manner with dextran sulfate present. We conclude that the high affinity but not the low affinity sites require Ca2+; only the low affinity sites are dextran sulfate-sensitive. Neither transferrin nor asialo-orosomucoid blocked lactoferrin binding to hepatocytes. Some cationic proteins but not others inhibited lactoferrin binding. At 37 degrees C, hepatocytes endocytosed 125I-apo-Lf and 125I-holo-Lf similarly, and hyperosmolality (greater than 500 mmol/kg) blocked uptake by approximately 90%. These data support the proposal that hepatocytes regulate blood lactoferrin concentration by receptor-mediated endocytosis.
Synthesis and deposition of silicon nitride films by laser reactive ablation of silicon in low pressure ammonia: A parametric study (1996)

The UV laser (λ=308 nm) ablation of silicon wafers in 1 mbar ambient ammonia results in the deposition of pure and uniform film of amorphous silicon nitride. At low pressures of NH3 (of several to several tens of μbar), the deposited films are a mixture of amorphous silicon nitride, amorphous nonstoichiometric silicon nitride, and amorphous silicon. The contamination with oxygen is low and is more evident at lower pressures. At ammonia pressures 0.1–1 mbar, the films also contain a certain fraction of hydrogen. Droplets of polycrystalline Si cover the surfaces of some films. This phenomenon is more important at smaller target-collector distances and lower pressures of ambient NH3.
Systematic and random defect reduction during the evolution of integrated circuit technology (1999)

As integrated circuit technology continues its historic progression down the road to ever diminishing feature size, device yield inhibitors due to systematic and random defects play an increasingly critical role in controlling the rates of technology learning and yield ramping. This paper presents a variety of new methods for facilitating random and systematic defect learning during the development of 0.18-0.25 micron Logic technology, emphasizing four principal activities - predicting random defect limited yield, improving process tool particle control, addressing systematic limited yield, and optimizing in-line defect inspections applied to both product and short flow monitors.
An Intrusion Detection Model Based on Deep Belief Network (2017)

The method of network intrusion detection based on deep learning is the hotspot of current research. This paper presents an intrusion detection model based on deep belief network and analyzes the NSL-KDD dataset. The experimental results show that the algorithm improves the detection of abnormal behavior pattern data and satisfies the requirement of high efficiency and reliability of intrusion detection system.
Anti‐<scp>IL</scp>‐5 attenuates activation and surface density of β<sub>2</sub>‐integrins on circulating eosinophils after segmental antigen challenge (2012)

IL-5 supports a heterogeneous population of circulating eosinophils with partially activated β(2) -integrins and is responsible for up-regulation of β(2) -integrins and PSGL-1 on circulating eosinophils following segmental antigen challenge but has minimal effects on properties of eosinophils in BAL. Dampening of β(2) -integrin function of eosinophils in transit to inflamed airway may contribute to the decrease in lung inflammation caused by anti-IL-5.
Clinical experience with molindone hydrochloride in geriatric patients. (1985)

Elderly patients (N = 28) with a variety of psychiatric disorders were treated with molindone in an 8-week open clinical trial. Many patients had concomitant medical illnesses, and many were on other medications in addition to molindone. Molindone appeared to be safe, clinically effective, and well-tolerated. The most common adverse effects were extrapyramidal side effects, but the occurrence of these symptoms was relatively low.
Purification and biochemical characterization of functional complement factor H from human plasma fractions (2012)

This novel process provides a pathogen-safe and functional CFH concentrate that can be produced on an industrial scale and is suitable for pre-/clinical studies.
Exact topology identification of large-scale interconnected dynamical systems from compressive observations (2011)

In this paper, we consider the problem of identifying the exact topology of an interconnected dynamical network from a limited number of measurements of the individual nodes. Within the network graph, we assume that interconnected nodes are coupled by a discrete-time convolution process, and we explain how, given observations of the node outputs, the problem of topology identification can be cast as solving a linear inverse problem. We use the term compressive observations in the case when there is a limited number of measurements available and thus the resulting inverse problem is highly underdetermined. Inspired by the emerging field of Compressive Sensing (CS), we then show that in cases where network interconnections are suitably sparse (i.e., the network contains sufficiently few links), it is possible to perfectly identify the topology from small numbers of node observations, even though this leaves a highly underdetermined set of linear equations. This can dramatically reduce the burden of data acquisition for problems involving network identification. The main technical novelty of our approach is in casting the identification problem as the recovery of a block-sparse signal x ∈ R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</sup> from the measurements b = Ax ∈ R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</sup> with M <; N, where the measurement matrix A is a block-concatenation of Toeplitz matrices. We discuss identification guarantees, introduce the notion of network coherence for the analysis of interconnected networks, and support our discussions with illustrative simulations.
Bovine Serum Growth Hormone, Corticoids and Insulin During Lactation1 (1973)

Serum GH and insulin were measured in 26 cows and serum corticoids were measured in 12 cows. Blood samples were collected 2–4 hr before, immediately after and 1 hr after milking for the duration of a lactation (44 weeks). Milking was associated with the release of corticoids and insulin but not GH. Serum GH was negatively associated with milk yield, especially after 24 weeks of lactation. This negative, relationship may be more directly caused by changes associated with concurrent pregnancy rather than with lactation per se, because serum GH concentrations decreased as lactation advanced, but increased as gestation progressed. Serum GH was greater (p < 0.05) during estrus than during the luteal phase of the estrous cycle of lactating cows. Serum insulin concentrations were inversely related to GH levels (increasing as lactation advanced, but decreasing as pregnancy progressed), and insulin was consistently negatively related to milk yields. Serum corticoids were variable, but on the average they changed very little as lactation advanced. Except for the overall correlation between serum corticoids measured immediately after milking and milk production (r = 0.19), serum corticoids generally were not significantly correlated with milk yields. (Endocrinology93: 645, 1973)
Patient satisfaction and duration of effect with PLLA: a review of the literature. (2009)

Poly-L-lactic acid (PLLA) has been available to the European medical community as a treatment for Human Immunodeficiency Virus (HIV)-associated facial lipoatrophy for nearly a decade, gaining U.S. Food and Drug Administration (FDA) approval for this indication in 2004. PLLA has been utilized in an off-label manner in the U.S. to treat lipoatrophy of aging in the non-HIV population. The literature regarding safety and efficacy of PLLA is well-documented, while studies regarding patient satisfaction and duration are more limited. The following review article discusses the currently available literature pertaining to the durability and patient satisfaction after PLLA treatment. Patients treated for HIV-related facial lipoatrophy and cosmetic use of PLLA for lipoatrophy of aging are discussed separately.
DUO: A phase 3 trial of the PI3K-δ,γ inhibitor IPI-145 versusofatumumab in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. (2014)

TPS7122 Background: Phosphoinositide 3-kinase (PI3K)-δ,γ isoforms are preferentially expressed in leukocytes and are central to the growth and survival of certain B and T cell malignancies. Inhibition of these isoforms by IPI-145, an oral PI3K-δ,γ inhibitor, has unique therapeutic potential in hematologic malignancies. IPI-145 has shown clinical activity and a favorable safety profile in a broad range of hematologic malignancies in an ongoing phase 1 trial (IPI-145-02). Based on these data, the DUO phase 3 trial (IPI-145-07; ClinicalTrials.gov number: NCT02004522) has been initiated to evaluate the efficacy and safety of IPI-145 compared to ofatumumab in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Methods: This open-label, two-arm trial includes adult patients with active CLL/SLL who meet at least one of the International Workshop on CLL (IWCLL) 2008 treatment criteria; have disease progression during or after previous CLL therapy; are not appropriate for purine analog-based therapy; and not refractory to ofatumumab. The trial will enroll approximately 300 patients, randomized 1:1 to IPI-145 or ofatumumab at sites in and outside the US. Patients randomized to IPI-145 will receive 25 mg IPI-145 orally, twice daily in 28-day treatment cycles for up to 18 cycles or until disease progression or unacceptable toxicity. After 18 cycles, patients may receive additional cycles of IPI-145 for up to 3 years, if they have documented evidence of response and disease requiring continued treatment. Patients randomized to ofatumumab will receive treatment consistent with the approved product label. Patients on both arms will be followed for up to 3 years from the first dose of study drug. The primary efficacy endpoint is progression-free survival. Key secondary endpoints include safety, overall survival and pharmacokinetic parameters. Patients with progressive disease during the trial may be eligible to receive the opposite study medication in a separate Infinity-sponsored extension protocol (IPI-145-12). This trial is currently enrolling patients. Clinical trial information: NCT02004522.
Detection of fast neutrons and digital pulse-shape discrimination between neutrons and gamma rays (2007)

The basic principles of detection of fast neutrons with liquid scintillator detectors are reviewed, together with a real example in the form of the Neutron Wall array. Two of the challenges in neutron detection, discrimination of neutrons and gamma rays and identification of cross talk between detectors due to neutron scattering, are briefly discussed, as well as possible solutions to these problems. The possibilities of using digital techniques for pulse-shape discrimination are examined. Results from a digital and analog versions of the zero cross-over algorithm are presented. The digital pulse-shape discrimination is shown to give, at least, as good results as the corresponding analogue version.
NMR assignments of alkylcyclopentadienyl ligands in zirconium and platinum complexes (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNMR assignments of alkylcyclopentadienyl ligands in zirconium and platinum complexesRichard A. Newmark, Larry D. Boardman, and Allen R. SiedleCite this: Inorg. Chem. 1991, 30, 4, 853–856Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/ic00004a048https://doi.org/10.1021/ic00004a048research-articleACS PublicationsRequest reuse permissionsArticle Views268Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Isolation and Identification of Styrene-degrading<i>Corynebacterium</i>Strains, and Their Styrene Metabolism (1996)

By supplying styrene in the gas phase as the sole carbon and energy source, styrene-degrading aerobic microorganisms were readily isolated from soil samples. They were identified as Corynebacterium pseudodiphtheriticum and similar species, or Pseudomonas sp. Growth experiments on some aromatic compounds, resting-cell reactions with them, and the measurement of degrading enzyme activities suggest that Corynebacterium sp. AC-5 and St-5 strains metabolize styrene through styrene oxidation into styrene oxide, then convert it into phenylacetaldehyde by a reaction using styrene oxide isomerase, and phenylacetaldehyde is reduced to 2-phenylethanol. The Corynebacterium sp. ST-10 strain did not have styrene oxide isomerase, and metabolized styrene oxide by an unknown enzymatic reaction. Possible metabolism of styrene was proposed for the Corynebacterium strains.
Adaptive Control of Multi-Tiered Web Applications Using Queueing Predictor (2006)

How to effectively allocate system resources to meet service level objectives (SLOs) is a challenging problem for Web services providers. In this paper, we propose a scheme for autonomous performance control of Web applications. It uses a queueing model predictor and an online adaptive feedback loop that enforces admission control of the incoming requests to ensure the desired response time target is met. The proposed queueing-model-based adaptive control approach combines both the modeling power of queueing theory and self-tuning power of adaptive control. Therefore, it can handle both modeling inaccuracies and load disturbances in a better way. To evaluate the proposed approach, we built a multi-tiered Web application testbed with open-source components widely used in industry. Experimental studies conducted on the testbed demonstrated the effectiveness of the proposed approach
A Wideband Study of the Bandwidth, SAR and Radiation Efficiency of Mobile Terminal Antenna Structures (2007)

In this paper, the frequency dependence of bandwidth, SAR and radiation efficiency of mobile terminal antennas are studied at wide frequency range, from 0.6 GHz to 6 GHz. Two antenna models are studied with simulations in free space and in talk-position beside a head model and two hand models. The results show a connection between chassis resonant frequencies, impedance bandwidth, SAR, and radiation efficiency, increase in SAR and decrease in radiation efficiency occur when bandwidth reaches its maximum due to a chassis resonance. Above 3 GHz this trend is shown to be not valid any more, as radiation of the antenna/coupling element become dominant. The results of the paper provide novel and useful information for the antenna designers of future mobile terminals
Stochastic Dynamic Games in Belief Space (2021)

Information gathering while interacting with other agents under sensing and motion uncertainty is critical in domains such as driving, service robots, racing, or surveillance. The interests of agents may be at odds with others, resulting in a stochastic noncooperative dynamic game. Agents must predict others’ future actions without communication, incorporate their actions into these predictions, account for uncertainty and noise in information gathering, and consider what information their actions reveal. Our solution uses local iterative dynamic programming in Gaussian belief space to solve a game-theoretic continuous POMDP. Solving a quadratic game in the backward pass of a game-theoretic belief-space variant of iterative linear-quadratic Gaussian control (iLQG) achieves a runtime polynomial in the number of agents and linear in the planning horizon. Our algorithm yields linear feedback policies for our robot, and predicted feedback policies for other agents. We present three applications: Active surveillance, guiding eyes for a blind agent, and autonomous racing. Agents with game-theoretic belief-space planning win 44% more races than without game theory and 34% more than without belief-space planning.
The concomitant use of tyrosine kinase inhibitors and proton pump inhibitors: Prevalence, predictors, and impact on survival and discontinuation of therapy in older adults with cancer (2019)

Nearly 1 in 4 older adults with cancer who receive TKIs also receive PPIs concomitantly, and concomitant use is associated with an increased risk of death. Concerted efforts to manage medications are needed to identify and reduce the receipt of PPIs when TKIs are initiated.
Expression of tfdA genes in aquatic microbial communities during acclimation to 2,4-dichlorophenoxyacetic acid (2002)

The role of gene expression during acclimation of aquatic microbial communities was examined by relating transcription of tfdA to the degradation of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). The tfdA gene encodes for a 2,4-D/2-oxoglutarate dioxygenase that transforms 2,4-D to 2,4-dichlorophenol. Transcription of tfdA, the abundance of tfdA genes and 2,4-D degrading populations, and the rate of 2,4-D disappearance were followed in laboratory incubations of two pond water samples that were exposed to 0.11 mM 2,4-D. Both communities responded to 2,4-D exposure by induction of tfdA transcription but the dynamics of transcript abundance and the homology to the tfdA riboprobe suggested different populations of 2,4-D degraders in the two ponds. In one community, where tfdA transcripts were highly homologous to the tfdA gene of Ralstonia eutropha JMP134, transcription of tfdA was transient and dropped while 2,4-D degradation continued. In the other freshwater community, where tfdA genes with a lower similarity to the tfdA gene of strain JMP134 were transcribed, transcript levels remained high although 2,4-D degradation had ceased. Restriction fragment length polymorphism analysis of tfdA amplicons similarly demonstrated the presence of different tfdA loci in the two freshwater communities, and this difference in populations of tfdA genes probably explains the observed difference in dynamics of catabolic gene transcription.
Global-aware and multi-order context-based prefetching for high-performance processors (2011)

Data prefetching is widely used in high-end computing systems to accelerate data accesses and to bridge the increasing performance gap between processor and memory. Context-based prefetching has become a primary focus of study in recent years due to its general applicability. However, current context-based prefetchers only adopt the context analysis of a single order, which suffers from low prefetching coverage and thus limits the overall prefetching effectiveness. Also, existing approaches usually consider the context of the address stream from a single instruction but not the context of the address stream from all instructions, which further limits the context-based prefetching effectiveness. In this study, we propose a new context-based prefetcher called the Global-aware and Multi-order Context-based (GMC) prefetcher. The GMC prefetcher uses multi-order, local and global context analysis to increase prefetching coverage while maintaining prefetching accuracy. In extensive simulation testing of the SPEC-CPU2006 benchmarks with an enhanced CMP$im simulator, the proposed GMC prefetcher was shown to outperform existing prefetchers and to reduce the data-access latency effectively. The average Instructions Per Cycle (IPC) improvement of SPEC CINT2006 and CFP2006 benchmarks with GMC prefetching was over 55% and 44% respectively.
RFID in Metal Environments: An Overview on Low (LF) and Ultra-Low (ULF) Frequency Systemsled (2010)

Inductive coupling-based systems show different problems to work in the presence of metals. The low frequency (LF) systems can work with metals in the surroundings. However, they only can work through metals in some particular circumstances and designs. The different problems arising from metal non-cleaned surroundings have been showed in section 2. All these problems could be avoided if the working frequency is reduced. However, the inductive coupling becomes inefficient quickly. We have developed and experimentally tested a new system to work through metals. It is shown in Section 3. It works at ultra low frequencies (1 - 100 kHz) and through metals. The new RFID system works without any resonant circuit. It is based on measuring changes of the magnetization of a magnetic core included in the tag. Different geometrical arrangements for the antenna and the reader have been designed. This is of importance since the magnetic fields produced by these antennas have different directions in the position of the tag. The characteristics of the antennas can be checked in (Ciudad et al., 2004) and (Ciudad Rio- Perez et al., 2008). A combination of those antennas will allow to avoid any directional problem. In addition, we give a theoretical model of the system. It allows a better design of the system for any particular application. In section 3.4 it is explained a theoretical model of the system. According to this model and our experimental data, the work distance is bellow 0.4 m for a typical antenna and low intensity magnetic fields. The system has demonstrated to be able to work through aluminium layers with thicknesses up to 0.2 mm and in close contact to the tag. Table 1 summarizes the characteristics of LF and ULF systems. The comments are relative to the different RFID systems. Some similar tables for other RFID systems can be found in (Wilding & Delgardo, 2004) and references therein.