gebhart/patrepeval huggingface dataset:
Ultra scale‐down characterization of the impact of conditioning methods for harvested cell broths on clarification by continuous centrifugation—Recovery of domain antibodies from rec <i>E. coli</i> (2013)

The processing of harvested E. coli cell broths is examined where the expressed protein product has been released into the extracellular space. Pre-treatment methods such as freeze-thaw, flocculation, and homogenization are studied. The resultant suspensions are characterized in terms of the particle size distribution, sensitivity to shear stress, rheology and solids volume fraction, and, using ultra scale-down methods, the predicted ability to clarify the material using industrial scale continuous flow centrifugation. A key finding was the potential of flocculation methods both to aid the recovery of the particles and to cause the selective precipitation of soluble contaminants. While the flocculated material is severely affected by process shear stress, the impact on the very fine end of the size distribution is relatively minor and hence the predicted performance was only diminished to a small extent, for example, from 99.9% to 99.7% clarification compared with 95% for autolysate and 65% for homogenate at equivalent centrifugation conditions. The lumped properties as represented by ultra scale-down centrifugation results were correlated with the basic properties affecting sedimentation including particle size distribution, suspension viscosity, and solids volume fraction. Grade efficiency relationships were used to allow for the particle and flow dynamics affecting capture in the centrifuge. The size distribution below a critical diameter dependent on the broth pre-treatment type was shown to be the main determining factor affecting the clarification achieved.
<i>Streptococcus pneumoniae</i> -Induced Inhibition of Rat Ependymal Cilia Is Attenuated by Antipneumolysin Antibody (2004)

Ciliated ependymal cells line the ventricular surfaces and aqueducts of the brain. In ex vivo experiments, pneumolysin caused rapid inhibition of the ependymal ciliary beat frequency and caused ependymal cell disruption. Wild-type pneumococci and pneumococci deficient in pneumolysin caused ciliary slowing, but penicillin lysis of wild-type, not pneumolysin-deficient, pneumococci increased the extent of ciliary inhibition. This effect was abolished by antipneumolysin antibody. Ependymal ciliary stasis by purified pneumolysin was also blocked by the addition of antipneumolysin monoclonal antibodies. These data show that antibiotic lysis of Streptococcus pneumoniae can be detrimental to the ciliated ependyma and that antipneumolysin antibody may have a therapeutic potential.
Controllers or catalysts for change and improvement: would the real value for money auditors please stand up? (2003)

Public finance watchdogs and guardians of the public purse. These are just two of the labels branded on Auditors General over the years. Since their initiation into value for money audit only three decades ago, they have continually been exposing cases of public financing laxity. Each time the auditors approach a government organization, their reputation invariably precedes them. But what happens when the controllers decide to turn over a new leaf and become catalysts for change and improvement who have come to help managers improve their public organizations? Auditees, totally unaccustomed to seeking help from auditors, are understandably befuddled. On the other side of the coin, auditors are equally inexperienced at providing assistance to auditees. There is many a slip twixt cup and lip before the role confusion dissipates.
Dynamic compensation of thermal lensing and birefringence in high average power, Nd:Cr:GSGG lasers using a Variable Radius Mirror and a Reentrant Resonator (1998)

Microprocessor controlled multi-element adaptive optics in birefringence compensating resonators allowed burst mode and variable average power Q-switched and free-running operation over very broad operating ranges.
T-tube suction drainage and/or prophylactic antibiotics. A randomized study of 451 hysterectomies. (1976)

The technics of T-tube suction drainage of the retroperitoneal space and of prophylactic antibiotics were evaluated each alone and then in combination in a randomized study of 451 private patients undergoing abdominal or vaginal hysterectomy. As compared with results in a control group, suction drainage alone and prophylactic antibiotics alone were equally effective in reducing the incidence of postoperative pelvic infection and febrile morbidity. When the two technics were used in combination, there was further reduction in the incidence of pelvic infection and febrile morbidity. However, these results were not statistically different from those of either technic alone. Date are presented to indicate that hysterectomy is performed in a bacteriologically contaminated operative field and that a contaminated fluid collection routinely accumulates in the retroperitoneal space. It is therefore suggested that hysterectomy be managed as a potentially infected surgical wound.
Effect of molecular weight of additives on the conductivity of PEDOT:PSS and efficiency for ITO-free organic solar cells (2013)

We systematically investigated the effect of the molecular weight of additives on the conductivity of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) by using different concentrations and molecular weights of polyethylene glycol (PEG) and ethylene glycol (EG). The conductivity enhancement depends on both the molecular weight and concentration of PEG used. The conductivity of PEDOT:PSS was enhanced from 0.3 S cm−1 to 805 S cm−1 with 2% PEG but to only 640 S cm−1 with 6% EG. PEGs with molecular weight higher than 400 have too low mobility to impart the required screening effect, and hence, the conductivity enhancement is less. Through FTIR, XPS and AFM investigations, the mechanism for the conductivity enhancement is found to be charge screening between PEDOT and PSS followed by phase separation and reorientation of PEDOT chains leading to bigger and better connected particles. The molecular weight and concentration of PEG also affect solar cell performances even though the conductivities are the same. Due to their high conductivity and high transmittance, ITO-free organic solar cell devices fabricated using PEDOT:PSS treated with 2% PEG anodes exhibited performance almost equal to that of the ITO counterparts.
Establishment of human T-cell leukemia virus type I T-cell lymphomas in severe combined immunodeficient mice (1993)

Human T-cell leukemia virus type I (HTLV-I) is recognized as the etiologic agent of adult T-cell leukemia (ATL), a disease endemic in certain regions of southeastern Japan, Africa, and the Caribbean basin. Although HTLV-I can immortalize T lymphocytes in culture, factors leading to tumor progression after HTLV-I infection remain elusive. Previous attempts to propagate the ATL tumor cells in animals have been unsuccessful. Severe combined immunodeficient (SCID) mice have previously been used to support the survival of human lymphoid cell populations when inoculated with human peripheral blood lymphocytes (PBL). SCID mice were injected intraperitoneally with PBL from patients diagnosed with ATL, HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), or from asymptomatic HTLV-I-seropositive patients. Many of these mice become persistently infected with HTLV-I. Furthermore, after human reconstitution was established in these mice, HTLV-I-infected cells displayed a proliferative advantage over uninfected human cells. Lymphoblastic lymphomas of human origin developed in animals injected with PBL from two ATL patients. The tumor cells represented outgrowth of the original ATL leukemic clone in that they had monoclonal or oligoclonal integrations of the HTLV-I provirus identical to the leukemic clone and predominantly expressed the cell surface markers, CD4 and CD25. In contrast, cell lines derived by HTLV immortalization of T cells in vitro did not persist or form tumors when inoculated into SCID mice, indicating differences between in vitro immortalized cells and ATL leukemic cells. This system represents the first small animal model to study HTLV-I tumorigenesis in vivo.
Synthesis and characterization of estrogen 2,3- and 3,4-quinones. Comparison of DNA adducts formed by the quinones versus horseradish peroxidase-activated catechol estrogens (1992)

Catechol estrogens (CE) are among the major metabolites of estrone (E1) and 17 beta-estradiol (E2). Oxidation of these metabolites to semiquinones and quinones could generate ultimate carcinogenic forms of E1 and E2. The 2,3- and 3,4-quinones of E1 and E2 were synthesized by MnO2 oxidation of the corresponding CE, following the method for synthesizing E1-3,4-quinone [Abul-Hajj (1984) J. Steroid Biochem. 21, 621-622]. Characterization of these compounds was accomplished by UV, nuclear magnetic resonance, and mass spectrometry. The relative stability of these compounds was determined in DMSO/H2O (2:1) at room temperature, and the 3,4-quinones were more stable than the 2,3-quinones. The four quinones directly reacted with calf thymus DNA to form DNA adducts analyzed by the 32P-postlabeling method. The adducts were compared to those formed when the corresponding CE were activated by horseradish peroxidase (HRP) to bind to DNA. The E1- and E2-2,3-quinones formed much higher levels of DNA adducts than the corresponding 3,4-quinones. In addition, many of the adducts (70-90%) formed by the E1- and E2-2,3-quinones appeared to be the same as those formed by activation of 2-OHE1 or 2-OHE2 by HRP to bind to DNA. Little overlap was observed between the adducts formed by E1- and E2-3,4-quinones and HRP-activated 4-OHE1 and 4-OHE2. These results suggest that semiquinones and/or quinones are ultimate reactive intermediates in the peroxidatic activation of catechol estrogens.
Method for the preparation of porous silica antireflection coatings varying in refractive index from 122 to 144 (1992)

Coatings of refractive index that vary between 1.22 and 1.44 were prepared from combinations of a colloidal silica suspension and a polysiloxane solution. The polysiloxane acted both as a binder and a filler for the colloidal silica particles. Increasing ratios gave coatings of lower porosity, hence higher refractive index, and better abrasion resistance. This variation in refractive index allowed highefficiency quarter-wave antireflection coatings to be prepared on substrates whose index varied from 1.45 to 2.1. The laser damage thresholds of all the coatings were >50 J/cm(2) at a wavelength of 1.06 microm with a 10-ns pulse length.
False arrhythmia alarm suppression using ECG, ABP, and photoplethysmogram (2009)

A signal quality assessment scheme for the photoplethysmogram waveform recorded by a pulse oximeter has been created. The signal quality algorithm uses statistical methods on time-series and spectral analysis to locate high-frequency segments of the photoplethysmogram waveform. A photoplethysmogram pulse onset detector has been implemented for heart rate estimation. Application of the signal quality metric and photoplethysmogram pulse onset detector are demonstrated in an algorithm which suppresses false electrocardiogram critical arrhythmia alarms issued by bedside monitors in hospital intensive care units.
Tracking with deep neural networks (2013)

We present deep neural network models applied to tracking objects of interest. Deep neural networks trained for general-purpose use are introduced to conduct long-term tracking, which requires scale-invariant feature extraction even when the object dramatically changes shape as it moves in the scene. We use two-layer networks trained using either supervised or unsupervised learning techniques. The networks, augmented with a radial basis function classifier, are able to track objects based on a single example. We tested the networks tracking capability on the TLD dataset, one of the most difficult sets of tracking tasks and real-time tracking is achieved in 0.074 seconds per frame for 320×240 pixel image on a 2-core 2.7GHz Intel i7 laptop.
Asynchrony in image analysis: using the luminance-to-response-latency relationship to improve segmentation (1994)

We deal with the problem of segmenting static images, a procedure known to be difficult in the case of very noisy patterns. The proposed approach rests on the transformation of a static image into a data flow in which the first image points to be processed are the brighter ones. This solution, inspired by human perception, in which strong luminances elicit reactions from the visual system before weaker ones, has led to the notion of asynchronous processing. The asynchronous processing of image points has required the design of a specific architecture that exploits time differences in the processing of information. The results obtained when very noisy images are segmented demonstrate the strengths of this architecture; they also suggest extensions of the approach to other computer vision problems.
Formal Verification of Consistency between Feature Model and Software Architecture in Software Product Line (2007)

During software development process, software artifacts are produced. Consistency among these artifacts should be verified to ensure error-free product. In software product line development, consistency becomes more important because commonalities and variabilities increase the complexity of relationship among artifacts. In this paper, we present a formal approach to verification of consistency between feature model and component and connector view of software architecture. By utilizing prototype verification system (PVS), we introduce our model of feature description and architecture description, and illustrate the consistency verification approach using a digital watch product line example.
Cancer Surveillance Series: Recent Trends in Childhood Cancer Incidence and Mortality in the United States (1999)

There was no substantial change in incidence for the major pediatric cancers, and rates have remained relatively stable since the mid-1980s. The modest increases that were observed for brain/CNS cancers, leukemia, and infant neuroblastoma were confined to the mid-1980s. The patterns suggest that the increases likely reflected diagnostic improvements or reporting changes. Dramatic declines in childhood cancer mortality represent treatment-related improvements in survival.
Rolofylline: a selective adenosine 1 receptor antagonist for the treatment of heart failure (2009)

Rolofylline facilitates diuresis and preserves renal function in patients with acute decompensated heart failure and renal dysfunction. Pilot data also suggest beneficial effects on symptoms and short-term outcomes. The risk of seizures may be minimized by excluding high-risk patients.
The Adsorption of Blood Coagulation Factors II, VII, IX and X from Human Plasma to Aluminium Hydroxide (1972)

Summary The influence of pH, adsorption time, ionic strength, buffer type and plasma concentration on adsorption and elution of the factors of the prothrombin complex from normal human ACD plasma onto A1(OH)3 is investigated. Reproducible small differences are found between the behaviour of the four factors II, VII, IX, and X.
In situ TEM study of the Li–Au reaction in an electrochemical liquid cell (2014)

We study the lithiation of a Au electrode in an electrochemical liquid cell using transmission electron microscopy (TEM). The commercial liquid electrolyte for lithium ion batteries (1 M lithium hexafluorophosphate LiPF6 dissolved in 1 : 1 (v/v) ethylene carbonate (EC) and diethyl carbonate (DEC)) was used. Three distinct types of morphology change during the reaction, including gradual dissolution, explosive reaction and local expansion/shrinkage, are observed. It is expected that significant stress is generated from lattice expansion during lithium-gold alloy formation. There is vigorous bubble formation from electrolyte decomposition, likely due to the catalytic effect of Au, while the bubble generation is less severe with titanium electrodes. There is an increase of current in response to electron beam irradiation, and electron beam effects on the observed electrochemical reaction are discussed.
Surface Chest Motion Decomposition for Cardiovascular Monitoring (2014)

Surface chest motion can be easily monitored with a wide variety of sensors such as pressure belts, fiber Bragg gratings and inertial sensors, etc. The current applications of these sensors are mainly restricted to respiratory motion monitoring/analysis due to the technical challenges involved in separation of the cardiac motion from the dominant respiratory motion. The contribution of heart to the surface chest motion is relatively very small as compared to the respiratory motion. Further, the heart motion spectrally overlaps with the respiratory harmonics and their separation becomes even more challenging. In this paper, we approach this source separation problem with independent component analysis (ICA) framework. ICA with reference (ICA-R) yields only desired component with improved separation, but the method is highly sensitive to the reference generation. Several reference generation approaches are developed to solve the problem. Experimental validation of these proposed approaches is performed with chest displacement data and ECG obtained from healthy subjects under normal breathing and post-exercise conditions. The extracted component morphologically matches well with the collected ECG. Results show that the proposed methods perform better than conventional band pass filtering.
Characterization of high molecular weight polycyclic aromatic hydrocarbons by charge exchange chemical ionization mass spectrometry (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of high molecular weight polycyclic aromatic hydrocarbons by charge exchange chemical ionization mass spectrometryWilliam J. Simonsick and Ronald A. HitesCite this: Anal. Chem. 1986, 58, 11, 2114–2121Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/ac00124a003https://doi.org/10.1021/ac00124a003research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Brain Hyperconnectivity in Children with Autism and its Links to Social Deficits (2013)

Autism spectrum disorder (ASD), a neurodevelopmental disorder affecting nearly 1 in 88 children, is thought to result from aberrant brain connectivity. Remarkably, there have been no systematic attempts to characterize whole-brain connectivity in children with ASD. Here, we use neuroimaging to show that there are more instances of greater functional connectivity in the brains of children with ASD in comparison to those of typically developing children. Hyperconnectivity in ASD was observed at the whole-brain and subsystems levels, across long- and short-range connections, and was associated with higher levels of fluctuations in regional brain signals. Brain hyperconnectivity predicted symptom severity in ASD, such that children with greater functional connectivity exhibited more severe social deficits. We replicated these findings in two additional independent cohorts, demonstrating again that at earlier ages, the brain of children with ASD is largely functionally hyperconnected in ways that contribute to social dysfunction. Our findings provide unique insights into brain mechanisms underlying childhood autism.
Turbulent-Gas Chromatography (1966)

Turbulent flow in gas chromatography was achieved and its effect was studied with high-speed, high-pressure equipment. A gas-solid capillary and several packed columns were used. The onset of turbulence was associated with abrupt decrease in peak width in the capillary and gradual leveling off and decrease in the Packed width in the existence of separation under turbulent conditions was shown. The Potential of the method was demonstrated by its short elution times and generation of theoretical Plates.
Collisional processes of hydrocarbons in hydrogen plasmas (1987)

We have investigated the reactions of methane and its derivatives with hydrogen plasmas for use in modelling carbon and hydrocarbon transport in hydrogen plasmas. We provide quantitative information over the temperature range from 0.1 eV to 2 keV for the most significant reactions of methane and methane fragments with electrons and protons. We review the properties of each reaction, present graphs of the cross section and reaction rate coefficient, and give analytical fits for sigma and (sigmav). 34 refs.
Texture segmentation by multiscale aggregation of filter responses and shape elements (2003)

Texture segmentation is a difficult problem, as is apparent from camouflage pictures. A Textured region can contain texture elements of various sizes, each of which can itself be textured. We approach this problem using a bottom-up aggregation framework that combines structural characteristics of texture elements with filter responses. Our process adaptively identifies the shape of texture elements and characterize them by their size, aspect ratio, orientation, brightness, etc., and then uses various statistics of these properties to distinguish between different textures. At the same time our process uses the statistics of filter responses to characterize textures. In our process the shape measures and the filter responses crosstalk extensively. In addition, a top-down cleaning process is applied to avoid mixing the statistics of neighboring segments. We tested our algorithm on real images and demonstrate that it can accurately segment regions that contain challenging textures. 1
The inertial lift on a rigid sphere in a linear shear flow field near a flat wall (1994)

An expression which predicts the inertial lift, to lowest order, on a rigid sphere translating in a linear shear flow field near a flat infinite wall has been derived. This expression may be used when the wall lies within the inner region of the sphere's disturbance flow. It is valid even when the gap is small compared to the radius of the sphere. When the sphere is far from the wall, the lift force predicted by the present analysis converges to the value predicted by earlier analyses which consider the sphere as a point force or a force doublet singularity. The effect of rotation of the sphere on the lift has also been analysed.