gebhart/patrepeval huggingface dataset:
Resonant-Tunneling Transistors Using InGaAs-Based Materials (1988)

This paper reviews our current research activities into resonant-tunneling hot electron transistors (RHETs) and resonant-tunneling bipolar transistors (RBTs) and describes our recent advances in these device technologies using InGaAs-based materials. The InGaAs-based RHET's common-emitter current gain at 77K is typically 17 (with a maximum of 25), which is about four times greater than that of a GaAs-based RHET. The collector current peak-to-valley ratio reaches 19.3 (with a maximum of 21.7). This is eight times that of the GaAs-based RHET. The InGaAs-based RBTs have been operated at room temperature with a current gain of 26 and a collector current peak-to-valley ratio of 2.3. The scattering parameters of the InGaAs-based RBT have been measured in a frequency range from 0.2 to 20.2 GHz. The cutoff frequency fT is measured as 12.4 GHz, indicating an emitter-to-collector delay of 12.8 ps. The delay due to the resonant-tunneling barrier used for this RBT is estimated to be 1.4 ps using an equivalent RBT circuit analysis.
Asymmetric Copper-Catalyzed Synthesis of α-Amino Boronate Esters from<i>N</i>-<i>tert</i>-Butanesulfinyl Aldimines (2008)

A general and efficient new method for the asymmetric synthesis of alpha-amino boronate esters has been developed. The key step is the Cu(I)-catalyzed addition of bis(pinacolato)diboron to N-tert-butanesulfinyl aldimines, which proceeds in good yields (52-88%) and with very high diastereoselectivities (>96:2) for a variety of aldimine substrates. This method was applied to an efficient synthesis of bortezomib, a potent alpha-amino boronic acid inhibitor of the proteasome that is in clinical use for the treatment of multiple myeloma and mantle cell lymphoma.
Lower power by voltage stacking (2016)

Stacking voltage domains on top of each other is a design approach that is getting the attention of engineering communities due to the implicit high efficiency of the power delivery. Previous works have shown voltage stacking at the core level only. In this paper we present a more involved approach required to deploy voltage stacking not at the core level but at the IP level of a complex microcontroller. Our demonstrator chip features an ARM Cortex M0+ platform with an on-chip switched-capacitor voltage regulator. We chose to place the standard logic in one voltage domain between ground and VDD, and the memory "on top of it" between VDD and 2VDD, creating in this way a voltage stacked system. We further present silicon measurements that include a measured peak power efficiency in "stacked mode" of 96%.
Linewidth enhancement factor in InGaAsP/InP multiple quantum well lasers (1987)

The linewidth enhancement factor α in an InGaAsP/InP multiple quantum well (MQW) laser has been determined from the spontaneous emission spectra below threshold. It is demonstrated that the measured value of α in the MQW laser is appreciably smaller than that in a conventional double heterostructure laser as expected from theoretical calculations.
PI3 Kinases in Cancer: From Oncogene Artifact to Leading Cancer Target (2006)

At the time of its discovery in the 1980s, the lipid kinase activity found associated with certain viral oncoproteins, which we now know to originate from the class IA phosphatidylinositide 3-kinases (PI3Ks), was thought by many to be a purification artifact. Subsequent work identified these enzymes as key regulators of cell signaling pathways that control various cellular processes including proliferation, motility, survival, and apoptosis. It is now clear that the PI3K pathway is activated by genetic or epigenetic alterations in a large proportion of human tumors, and a search for small molecule inhibitors of PI3K activity is currently a major effort of the pharmaceutical industry. However, because of the importance of PI3Ks in normal physiology, the road to therapeutics might not be smooth and could require further dissection of PI3K signaling pathways. In particular, it may be important to distinguish among the roles of the various isoforms of class 1A PI3K in both normal physiology and tumorigenesis.
Prevalence of <i>ESR1</i> Mutations in Cell-Free DNA and Outcomes in Metastatic Breast Cancer (2016)

clinicaltrials.gov Identifier: NCT00863655.
Synthesis and Biological Validation of a Ubiquitous Quorum‐Sensing Molecule (2004)

Chemical communication (“quorum sensing”) amongst bacteria has been studied by the synthesis and study of enantiopure (R)-4,5-dihydroxy-2,3-pentanedione (DPD, see scheme). Bioactivity assays with DPD have shown that chelation of boron by the cyclic form of DPD appears to be essential for full induction of bioluminescence, which is an example of quorum-sensing-controlled behavior. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z53150_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Mapping America’s teacher evaluation plans under ESSA (2019)

In 2016, the federal government proposed and adopted the Every Student Succeeds Act, which retracted the federal government’s prior control over states’ teacher evaluation systems, permitting more local control. Kevin Close, Audrey Amrein-Beardsley, and Clarin Collins collected information from states to determine the degree to which states were shifting away from the value-added models (VAMs) that were ascendant under No Child Left Behind and Race to the Top and to understand what kinds of evaluation methods they are employing instead. States do appear to be moving slowly away from VAMs, continuing to use teacher observations, and incorporating student learning objectives as growth measures. Local control and more formative use of teacher evaluations also appear to be on the rise.
Self-diffusion coefficients of water in pure water and in aqueous solutions of several electrolytes with 18O and 2H as tracers (1978)

The self-diffusion coefficients of water in pure water and in aqueous electrolyte solutions have been measured by using the sintered glass diaphragm cell technique with 2H and 18O as tracers. The extrapolated value from 2H tracer data, 2.27 × 10–9 m2 s–1, agrees with the value from 18O tracer data which is less sensitive to tracer concentration. In most electrolyte solutions investigated, no significant isotope effect in water diffusion was observed.
Compact self-aligned external cavity lasers using volume gratings (2009)

We experimentally demonstrate a compact self-aligned external cavity 25W high power laser diode bar at 976 nm tunable over 0.5 nm with a bandwidth of 0.25 nm. The external cavity is based on double diffraction from a glass reflective volume holographic grating (VHG). The wavelength tuning is performed by rotation of the VHG. Passive alignment and fine wavelength tuning of the proposed external cavity are attractive new features over the state-of-the-art active alignment method and fixed wavelength limitation currently used in wavelength stabilized high power laser diode bars.
The Music of Poetry and the Music of Mind (2005)

Journal Article The Music of Poetry and the Music of Mind Get access C. K. Williams C. K. Williams Search for other works by this author on: Oxford Academic Google Scholar Literary Imagination, Volume 7, Issue 1, Winter 2005, Pages 19–29, https://doi.org/10.1093/litimag/7.1.19 Published: 01 December 2005
Assessment of Thromboembolism After the Cox-Maze Procedure for Chronic Atrial Fibrillation Secondary to Mitral Valve Lesion (2002)

These results are in accordance with others series, where the occurrence of embolism was rare after maze procedure. Permanent systemic anticoagulation seems to be unnecessary in those cases.
Ultrasonic Doppler Sensing in HCI (2012)

Several properties differentiate ultrasonic Doppler sensing from other sensing techniques-high frame rate, low computational overhead, instantaneous velocity readings, and range independence. Also, because it isn't vision-based, it might open doors to sensing in once taboo locations.
Vision based gait analysis on robotic walking stabilization system for patients with Parkinson's Disease (2014)

In this paper, we propose a gait analysis based walking stabilization system on an active robotic walker for Parkinson's Disease patient. We developed a vision based gait analysis that lower limbs from the frontal view which is captured by single RGB-D camera on the robotic walker. Our system constructs the lower limbs skeleton and kinematic model for calculating the walking gait features such as average walking step length, velocity, width and joint angles. When the user suffer in abnormal gait, the robotic walker assists user to stabilize their gaits through the adjustable control motion of walker according to the user's walking gait and prompting user with auditory cues. In experiment, we had invited Parkinson's Disease patients to test our system in senior care unit, the experimental results show that when the patients have relatively stable gait than without using this system.
School Choice (2002)

Abstract In recent years voucher programs that permit the use of publicly funded monies to pay for private schools have emerged as a proposed solution to perceived problems within the public school system. Lost in this debate are the implications of choice based proposals for children with disabilities. In this article the authors examine the legal basis for special education services and explore the extent to which the rights of children in a private choice based system would be protected. The authors conclude that serious questions of equity exist, with the dis-enfranchisement of children with special needs a likely consequence if vouchers are adopted on a broad scale.
High-temperature operation of SiC planar ACCUFET (1999)

In this paper, the authors discuss the high-temperature characteristics of novel planar vertical MOSFET structures (called ACCUFETs) fabricated from 6H-SiC and 4H-SiC polytypes. A room-temperature specific on-resistance (R/sub on,sp/) of 18 m/spl Omega//spl middot/cm/sup 2/ was measured on the best 6H-SiC device at a logic-level gate drive voltage of only 5 V, which was in excellent agreement with 15 m/spl Omega//spl middot/cm/sup 2/ obtained in simulations. The measured R/sub on,sp/ for the 6H-SiC ACCUFET is within 2.5/spl times/ of the drift region resistance which is the best value obtained so far for any high-voltage SIC MOSFET. The forward voltage drop of the best 6H-SiC ACCUFET at 50 A/cm/sup 2/ was 0.9 V, which is much less than that of a 1200-V insulated gate bipolar transistor (typically, 3 V for a high-speed device). The R/sub on,sp/ exhibits a positive temperature coefficient, which is extremely desirable, since it allows paralleling of devices and also improves reliability by avoiding current filamentation problems. In contrast, the R/sub on,sp/ for the best 4H-SiC reduced rapidly with increase in temperature. At room temperature, the unterminated 6H-SiC and 4H-SiC devices had a breakdown voltage of 350 V and 450 V, respectively, with a leakage current of <100 /spl mu/A.
Soluble glycoprotein D blocks herpes simplex virus type 1 infection of rat eyes (1992)

Herpes simplex virus type 1 (HSV-1) ocular infection in rats was blocked by treating the eyes with UV-inactivated virions containing glycoprotein D (gD) prior to ocular challenge. In contrast, rats treated with UV-inactivated virions lacking gD were not protected. A soluble, truncated form of HSV-2 gD (gD-2t) also protected against ocular infection. Treatment with gD-2t not only reduced mortality but also restricted progression of pathology and reduced the amount of viral antigen in the cornea. Host antibody or alpha/beta interferon responses to the gD-2t treatment were not detected. These results are similar to those observed in cell culture (D. C. Johnson, R. L. Burke, and T. Gregory, J. Virol. 64:2569-2576, 1990). The in vivo effect of exogenous gD is consistent with blocking of a cell surface gD receptor or with an inhibitory interaction of gD with virions.
Mast Cell Cytokine and Chemokine Responses to Bacterial and Viral Infection (2003)

Mast cells have been most widely studied in the context of allergic disease but also play a critical role in host defence against bacterial infection, most elegantly demonstrated in studies using mast cell deficient w/wv mice. There is less data available concerning the role of mast cells in defence against viral pathogens, however, mast cells have been demonstrated to be a potential reservoir of infection for several pathogens, such as HIV-1 and dengue, and capable of producing mediators following challenge with a number of viral products. Traditional mast cell mediators such as histamine, protease enzymes and leukotrienes are important for effective host responses. The cytokines and chemokines produced by mast cells in response to pathogens are known to profoundly alter the nature of the innate immune response and its effectiveness in eliminating infection. Cytokine and chemokine production by mast cells is closely regulated and may occur independently of classical mast cell degranulation. Depending upon the nature of the stimulus or type of infection, a unique profile of cytokines is induced. In this review, we will examine the role and regulation of mast cell cytokines and chemokines in the context of a number of bacterial and viral infections, emphasizing the multiple receptor mechanisms used to activate mast cells. This area of research is still in its early stages and much work remains to be done. However, understanding the unique properties of resident tissue mast cells and how their cytokine responses are regulated by pathogens or pathogen products, will provide important opportunities for the therapeutic manipulation of local immune responses.
Analysis of interface properties in MOS transistors by means of `charge pumping' measurements (1974)

When MOS transistors are driven from cut-off to saturation and vice-versa under the control of large gate pulses, a recombination process known as `charge pumping effect' takes place, inducing a leakage current in the substrate connection. The origin of this phenomenon is related to the presence of traps located at the Si/SiO/sub 2/ interface. Convenient experimental procedures enabling to test the influence of various parameters on the phenomenon have been set up. It appears that they provide a simple investigation means of the interface properties. Additional work resulted further in finding other sources of losses, among which the capture of carriers within the gate oxide and the effect of inversion under the bonding areas. A simple theory is developed in order to predict the contribution of these components to the substrate current.
The TNBS-induced colitis animal model: An overview (2016)

The aim of this study was to thoroughly present an updated review of the TNBS-induced colitis protocols that are implemented by researchers.
Simulation studies of broadband wireless systems employing code combining techniques (2002)

ATM is establishing itself as a universal standard and applications of constant length packet based communications are foreseen in the wireless environment as well. Antenna diversity techniques operating on a packet basis combined with coding are suggested as a means to improve the reliability of wireless connections and allow the extension of ATM-related protocols to the wireless domain. The comparative performance of a number of packet based diversity techniques employing punctured convolutional coding and block interleaving is evaluated. Results were obtained for post-Viterbi-decoding selection diversity and code-diversity combining for AWGN and Rayleigh fading radio channel models. Code combining using a type-II protocol on a Rayleigh fading channel was also examined. The results indicate the amount of interleaving required in a bursty channel for a code combining approach to surpass a post-detection selection diversity technique at various code rates.
Quantitative Evaluation of Corrosive Sulfur in Electrical Insulating Oil (2008)

Abstract This paper presents quantitative evaluation method of corrosive sulfur in insulating oil. The level of corrosion on copper strip which was aged in insulating oil is expressed numerically by the amount of sulfur on it. Since X‐ray strength by wave length dispersive X‐ray (WDX) and measurement value of sulfur on copper strip by titration show good correlation, the amount of sulfur can be obtained rapidly only by WDX. The performance of passivator such as BTA or Irgamet39 was quantitatively evaluated by WDX. The evaluation of life of passivator was also achieved. Copyright © 2008 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Integrated Circuit Packaging (2018)

No AccessMolding Simulation: Theory and PracticeJun 2018Integrated Circuit PackagingMaw-Ling Wang, Rong-Yeu Chang, Chia-Hsiang (David) HsuMaw-Ling Wang, Rong-Yeu Chang, Chia-Hsiang (David) Hsuhttps://doi.org/10.3139/9781569906200.017SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2018Pages: 475-508Print ISBN: 978-1-56990-619-4eISBN: 978-1-56990-620-0 Copyright & Permissions© 2018 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family (2008)

Mutations in several ribosomal proteins (RPs) lead to Diamond-Blackfan anemia (DBA), a syndrome characterized by defective erythropoiesis, congenital anomalies, and increased frequency of cancer. RPS19 is the most frequently mutated RP in DBA. RPS19 deficiency impairs ribosomal biogenesis, but how this leads to DBA or cancer remains unknown. We have found that rps19 deficiency in ze-brafish results in hematopoietic and developmental abnormalities resembling DBA. Our data suggest that the rps19-deficient phenotype is mediated by dysregulation of deltaNp63 and p53. During gastrulation, deltaNp63 is required for specification of nonneural ectoderm and its up-regulation suppresses neural differentiation, thus contributing to brain/craniofacial defects. In rps19-deficient embryos, deltaNp63 is induced in erythroid progenitors and may contribute to blood defects. We have shown that suppression of p53 and deltaNp63 alleviates the rps19-deficient phenotypes. Mutations in other ribosomal proteins, such as S8, S11, and S18, also lead to up-regulation of p53 pathway, suggesting it is a common response to ribosomal protein deficiency. Our finding provides new insights into pathogenesis of DBA. Ribosomal stress syndromes represent a broader spectrum of human congenital diseases caused by genotoxic stress; therefore, imbalance of p53 family members may become a new target for therapeutics.
Ferroelectric properties of vinylidene fluoride copolymers (1989)

Abstract Ferroelectric properties of copolymers of vinylidene fluoride with trifluoroethylene and tetrafluoroethylene are described with special interest in their polarization reversal and phase transition behavior. The ferroelectric phase consists of all-trans molecules packed in a parallel fashion while molecules adopt irregular TT, TG, T[Gbar] conformations in the paraelectric phase. In the ferroelectric phase, polarization reversal occurs at very high fields (> 100 MV/m) as a result of eventual 180° rotations of individual chain molecules around their axes. The switching time ranges from sec to nsec depending upon the strength of the applied field according to an exponential law with a particularly large activation field (∼ 1 GV/m). The value of the observed remnant polarization is consistent with prediction from a simple dipole sum implying a minor contribution from the Coulomb interaction. The ferroelectric-to-paraelectric transition appears most clearly for copolymers containing 50-80 mol% vinylidene fluoride at temperatures from 70 to 140°C. The transition accompanies cooperative dipole motions associated with elementary trans-gauche transformations. Changes in various properties as well as in structures in the vicinity of the Curie point are consistent with an order-disorder transition of first order. Detailed characteristics specifying their ferroelectricity are summarized and discussed in relation to the molecular, crystalline, and higher-order structures inherent to ferroelectric polymers.
Superconductivity Studies on the High T<sub>c</sub> Phase in the Y–Ba–Cu–O System (1987)

Synthesis, characterization and superconducting behavior of the phases (i) Y 2-x Ba x Cu 2 O 5 (0\leqslantx\leqslant1.6) and (ii) YBa 2 Cu 3+x O 7+y (0\leqslantx\leqslant2.0) are reported. The composition YBa 2 Cu 4 O 7+y shows a T c (zero resistance) of 94K.
A 2‐DE MALDI‐TOF study to identify disease regulated serum proteins in lung cancer of c‐myc transgenic mice (2009)

We previously reported targeted overexpression of c-myc to alveolar epithelium to cause lung cancer. We now extended our studies to the serum proteome of tumor bearing mice. Proteins were extracted with a thiourea-containing lysis buffer and separated by 2-DE at pH 4-7 and 3-10 followed by MALDI-TOF/TOF analysis. Forty-six proteins were identified in tumor bearing mice of which n = 9 were statistically significant. This included disease regulated expression of orosomucoid-8, alpha-2-macroglobulin, apolipoprotein-A1, apolipoprotein-C3, glutathione peroxidase-3, plasma retinol-binding protein, and transthyretin, while expression of apolipoprotein-E was decreased at late stages of disease. Moreover, serum amyloid P component was uniquely expressed at late stages of cancer. It is of considerable importance that most disease regulated proteins carried the E-Box sequence (CACGTG) in the promoter of the coding gene, therefore providing evidence for their regulation by c-myc. Notably, expression of alpha-2-macroglobulin, transthyretin, alpha-1-antitrypsin, and properdin was in common in different lung tumor models, but regulation of orosomucoid-8, apolipoprotein-A1, apolipoprotein-C3, apolipoprotein-E, glutathione peroxidase-3, plasma retinol-binding protein, and serum amyloid P component was unique when the serum proteomes of c-myc and c-raf tumor bearing mice were compared. Therefore, candidate biomarkers to differentiate between atypical adenomatous hyperplasias (AAH) and bronchiolo-alveolar carcinomas (BAC)/papillary adenocarcinomas (PLAC) can be proposed.