gebhart/patrepeval huggingface dataset:
SOCS3 regulates B lymphopoiesis at the immature B cell stage (86.4) (2007)

Abstract CXCL12-mediated FAK phosporylation and sustained pro-adhesive responses occur uniquely in progenitor bone marrow (BM) B cells, but not in mature peripheral B cells. Since CXCR4 receptor expression is similar at all B cell stages, we hypothesized that progenitor and mature B cells possess different mechanisms to control FAK phosphorylation. Here we demonstrate that Suppressor of Cytokine Signaling 3 (SOCS3) regulates CXCL12-induced FAK phosphorylation through the ubiquitin-proteosome pathway. CXCL12 triggers increased FAK ubiquitination in peripheral B cells and spleen B cells, but not in BM B cells. In accordance with this finding, SOCS3 expression is relatively low in progenitor BM B cells and high in peripheral blood and spleen B cells. Over-expression of SOCS3 results in decreased CXCL12-induced FAK phosphorylation and impaired adhesion to VCAM1. Next, we examined B lineage cells from MMTV-Cre SOCS3fl/flmice in which SOCS3 protein expression was reduced greater than 95%. SOCS3 deficient splenic B cells have increased and prolonged FAK phosphorylation and enhanced sustained adhesion to VCAM-1, similar to progenitor B cells. MMTV-Cre SOCS3fl/flmice have a two-fold increase in the absolute number of IgM+,IgD−, immature B cells in BM compared to wild type mice (n=8, p&lt;0.01). IL-7 dependent pre-B cell proliferation was unaffected by SOCS3 deficiency. However, withdrawal of IL-7 induced the generation of immature B cells that survived longer in culture compared with wild type cells. Taken together, our results suggest that SOCS3 may be an important negative regulator of immature B cells by affecting their survival and pro-adhesive responses in the bone marrow microenvironment.
Empirical Validation of Yield Recovery Using Idle-Cycle Insertion (2007)

The act of applying a scan-based delay test to a chip can cause electrical disturbances in the power and clock distribution networks that affect the results of the test, either for better or for worse. Empirical data presented in this study suggest that altering the details of the delay test application protocol can have a significant effect on the test results, and thus the yield of the product being tested. Specifically, inserting wait states between scan shifting and the launch clock results in measurable yield improvement. Although the exact mechanisms involved remain elusive, the authors were able to eliminate several possibilities through a series of experiments. It is clear from these experiments that yield recovery is a real phenomenon, and that launch delay (LD) tests can help to recover from IR drop.
Microwave-assisted ring closure reactions: Synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones (2006)

A new, fast, and efficient ring closure method for the imidazole ring of xanthine derivatives and related tricyclic compounds has been developed. Apart from improving the syntheses of known compounds, some of which are important pharmacological tools or in development as novel drugs, it allows the preparation of 2-substituted diazepino [1,2,3-cd]purines--a new class of tricyclic purine derivatives.
Powermesh medium access control protocol (2011)

Powermesh MAC protocol is a relatively simple protocol designed for applications that mostly have a regular schedule of data transport activities such as routine status reports of a monitored power system. In particular, this protocol is designed for sensor network nodes that tend to be arranged in an approximately linear configuration, such as along the power lines. The Powermesh MAC protocol is designed with a special intention to allow the nodes to have low duty-cycles. A special feature of this protocol is that each node transmits its own beacon to announce its presence and to send signaling information related to the available time slots. The individual beacons and individual neighbourhood maps are the basic features of the Powermesh MAC protocol. The neighbourhood map is a small data structure which indicates timeslot usage by the node's neighbours. The Powermesh MAC addresses the hidden terminal problem and the exposed terminal problems by individual beacons and neighborhood maps.
Solid modelling with constraints and parameterised features (2002)

This paper presents solutions to the interactive design of 3D objects with parameterised features and constraints. In the introduction, we describe some new industrial needs in computer-assisted design. In the second part, we give an outline of an object-oriented dual modeller we have developed. The third part is devoted to the parametric and constraint-based design approach. The subject of the last part is design by features and the evolution toward the functional design of complex 3D objects.
Design and operating experience of EBR-II intermediate heat exchanger (1979)

Experimental Breeder Reactor II (EBR-II) has operated for over 15 years at the Idaho National Engineering Laboratory near Idaho Falls. EBR-II has served the nation in providing information on fuels, materials, and components under conditions approaching those expected for commercial power plants. In addition, EBR-II is a power plant generating electricity with an availability of about 70%. A key component, the Intermediate Heat Exchanger (IHX), of any Liquid Metal Fast Breeder Reactor (LMFBR) must perform with a high degree of reliability for successful commercialization. The design and operating experience gained from EBR-II demonstrates that the IHX can be built and operated with confidence that its performance and reliability will be satisfactory.
Hypotension During Hospitalization for Acute Heart Failure Is Independently Associated With 30-Day Mortality (2014)

http://www.clinicaltrials.gov. Unique identifier: NCT00475852.
Role of starch and metabisuphite on pure pyrite and pyritic copper ore flotation (2012)

Depression of pyrite is very important in sulphide ore flotation. This paper investigates the role of non-toxic depressants on the flotation of pyrite. Starch and meta bisulphite were used as a depressant for pure pyrite sample and a pyritic copper ore at two different pHs values. pH was 6.5 and 10 in pure pyrite study while it was 6.9 and 12 in pyritic ore study. This study showed that metabisulphite is more effective at pH 6.5 or 6.9 than pH 10 or 12, while starch is more effective at pH 12. Also, higher dosages of meta bisulphite are required for depression of pyrite. Pure pyrite and pyritic copper ore study gave similar results.
Two Epimeric Flavalignans from Trichilia catigua (Meliaceae) with Antimicrobial Activity (2002)

A mixture of flavalignan cinchonains Ia and Ib was isolated from the bark of Trichilia catigua. The structures were established on the basis of spectroscopic data of the natural products and their methylated derivatives including 2D NMR experiments, and compared with data in the literature. These flavalignans exhibited antibacterial activity against Bacillus
17 GHz-bandwidth 17 dB-gain 0.3 μm-HEMT low-power limiting amplifier (2002)

The design of a limiting amplifier with a high speed, a high gain, and a wide dynamic range is a basic task for the realization of high-speed data transmission systems. A limiting amplifier fabricated using Si-bipolar technology can be operated at 15 Gb/s with a power consumption of 720 mW. An AlGaAs/GaAs HBT limiting amplifier can be operated up to 15 GHz with a power consumption of 1.5 W. The HEMT limiting amplifier presented in this paper shows a higher bandwidth but needs a much lower DC power.
Evaluation of a new pedestrian head injury protection system with a sensor in the bumper and lifting of the bonnet’s rear part (2001)

Pedestrians are a high-risk group in vehicle impacts, especially in urban areas. In Europe pedestrians account for around 20 % of all traffic fatalities. In the rest of the world this frequency varies from 14 % in USA up to 47 % in Thailand. The majority of pedestrian fatalities are due to head impacts. Today’s cars are very densely packed under the bonnet. Certain stiff parts, such as the spring tower and the top of the engine, are very close to the bonnet. There is often not enough space for bonnet deformation by an impacting head. The consequence is often a severe or fatal head injury. Therefore, a protection system has been developed to
Transport and Reaction Processes in Soil (2010)

Syngenta is one of the worlds leading agrochemical companies. In order to register agrochemicals in Europe it is necessary to have a detailed understanding of the processes in the environment that break down agrochemicals. The existing framework for environmental assessment includes a consideration of soil water movement and microbial breakdown of products in soil and these processes are relatively understood and represented in models. However the breakdown of agrochemicals by the action of light incident on the soil surface by a process termed photolysis is not so well represented in models of environmental fate. The problem brought by Syngenta to the workshop was how to include the effects of light degradation of chemicals into predictive models of environmental fate.\nPhotolysis is known to occur in a very thin layer at the surface of soil. The workshop was asked to consider how the very rough nature of the upper surface of a ploughed field might affect the degradation of chemicals by sunlight. The discussions were directed down two avenues: firstly to determine how the very small distances over which photolysis occurs might be adequately incorporated into models of transport in soils and, secondly to consider how the rough surface might modify the illumination of the surface and hence alter degradation.\nThe rate of degradation by photolysis is measured in the laboratory by illuminating a thin, typically about 1 or 2 mm, layer of soil with very strong xenon lamps. The amount of chemical is measured at various intervals and is fitted to a first-order process. Field experiments where the chemical is sprayed on a bare field show evidence of photolysis indicated by biphasic degradation patterns and the presence of breakdown products only formed by photolysis.\nThis report addresses methods for mathematically modelling the action of photolysis on particular relevant chemical species. We start with a general discussion of mechanisms that transport chemicals within soil §2. There is an existing computational model exploited by Syngenta for such modelling and we discuss how this performs and the predictions that can be derived using it §3.\nThe particular mechanism of photolysis is then considered. One aspect of this mechanism that is investigated is how the roughness of the surface of the soil could be adequately incorporated into the modelling. Some results relating to this are presented §4.2. Some of the original experimental data used to derive aspects of the model of photolysis are revisited and a simple model of the process presented and shown to fit the data very well §5. By considering photolysis with a constant diffusion coefficient various analytical results are derived and general behaviour of the system outlined. This simple model is then applied to real field-based data and shown to give very good fit when simply extended to account for the moisture variations by utilising moisture dependent diffusion coefficients derived from the existing computational model §5.3. Some consequences of the simple model are then discussed §6.
Peptide Cyclization and Cyclodimerization by Cu<sup>I</sup>-Mediated Azide−Alkyne Cycloaddition (2009)

Head-to-tail cyclodimerization of resin-bound oligopeptides bearing azide and alkyne groups occurs readily by 1,3-dipolar cycloaddition upon treatment with Cu(I). The process was found to be independent of peptide sequence, sensitive to the proximity of the alkyne to the resin, sensitive to solvent composition, facile for alpha- and beta-peptides but not for gamma-peptides, and inhibited by the inclusion of tertiary amide linkages. Peptides shorter than hexamers were predominantly converted to cyclic monomers. Oligoglycine and oligo(beta-alanine) chains underwent oligomerization by 1,3-dipolar cycloaddition in the absence of a copper catalyst. These results suggest that cyclodimerization depends on the ability of the azido-alkyne peptide to form in-frame hydrogen bonds between chains in order to place the reacting groups in close proximity and lower the entropic penalty for dimerization. The properties of the resin and solvent are crucial, giving rise to a productive balance between swelling and interstrand H-bonding. These findings allow for the design of optimal substrates for triazole-forming ring closure and for the course of the reaction to be controlled by the choice of conditions.
Natural bioactive-based polyanhydrides for controlled release applications (2009)

Hydrolytically degradable polyanhydrides are of interest for a variety of controlled release applications because of their surface-eroding behavior and tunable degradation rate based on polymer chemical composition. Rather than physical admixtures, bioactives were chemically incorporated either directly into the polymer backbone or as pendant groups via hydrolytically degradable linkages.A series of poly(anhydride-esters) containing iodinated salicylates were synthesized via both melt-condensation and solution polymerization to generate X-ray opaque polymers. It was found that physical and mechanical properties were affected by polymerization technique, and thermal properties such as glass transition temperature were dependent on the amount of iodine in the polymer.The degradation rate of salicylic acid (SA)-based polyanhydrides was manipulated to release SA over prolonged periods of time (i.e., months) and over relatively short periods of time (i.e., days). First, a series of copolymers based on a SA-based diacid and highly aromatic comonomers 1,6-bis(o-carboxyphenoxy)hexane (o-CPH) and 1,6-bis(p-carboxyphenoxy)hexane (p-CPH) were developed. By changing the molar ratios of SA-based diacid to o-CPH or p-CPH, the thermal and mechanical properties of the resulting copolymers varied, and the degradation rate was decreased. Alternately, two methods were used to form fast-degrading polymers: changing the structure of the diacid’s “linker” molecule and synthesizing a copolymer containing a more hydrophilic comonomer. These polymers completely degraded in one week or less.Mono-functional antimicrobials were chemically incorporated as pendant groups via ester linkages to a polyanhydride backbone based on ethylenediaminetetraacetic acid, resulting in a completely bioactive polymer. The polymers degraded in less than 1 week, and some displayed the ability to completely prevent Salmonella biofilm formation. Lastly, polymers based on antimicrobial and antioxidant preservatives (i.e., hydroxycinnamates) were synthesized and found to release the preservatives over a prolonged period of time (> 1 month). Polymer degradation products exhibited antioxidant activity, and experiments indicated that free bioactives are responsible for antimicrobial activity. Furthermore, the polymers contain double bonds that can be crosslinked to form hydrophobic networks.
Measurement of dielectric loss tangent of aluminaatmicrowave frequencies and room temperature (1994)

The use of whispering gallery modes allows the dielectric loss tangent of polycrystalline Al2O3 (alumina) to be accurately determined at microwave frequencies without the use of a cavity. The dielectric loss tangent of alumina is shown to be strongly variable from sample to sample with a lowest measured value of 4.3 × 10-5 observed at 9.0 GHz in a 99.5% alumina sample.
A Double Sandwich Monoclonal Enzyme Immunoassay for Detection of Hepatitis B Surface Antigen (1993)

An enzyme immunoassay for detection of hepatitis B surface antigen based on the use of 3 monoclonal antibodies (mAbs) was developed: an IgM as capture and 2 IgG1 for detection. The system biotin-streptavidin was compared with direct conjugation of mAbs to peroxidase and was preferred because of its higher signal to noise ratio. The possibility of simultaneous addition of human serum and biotin-mAb was discarded because of an evident prozone effect with some sera containing high HBsAg levels. The conjugation of biotin to IgG1 mAbs through a spacer arm (amidocaproyl) and the use of a highly sensitive substrate (tetramethylbenzIdine) improved the assay detection limit by about 10 times.
Comparison of three different architectures for MOS-compatible quadratic synapses (2002)

Inspired by the harmony between the basic functional elements of biological neural networks and their natural operating media, we have been seeking for ways to implement artificial neural networks (ANNs) using the intrinsic functionality of the most commonly available devices in an electronics technology, in contrast to the method of hardware-compilation of software-simulation modules. In the case of MOS technology, we employ a quadratic functional equation similar to that found in standard MOS transistors to implement synapses in ANNs. A structure has been proposed in to implement a MOS device with externally-controllable threshold voltage to be employed as a synapse. In the present work, we develop and compare practical architectures within which these synapses can be utilized optimally. A simulator and proper training algorithms have been developed to simulate different hardware-based architectures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
TPU-0037-A, B, C and D, Novel Lydicamycin Congeners with Anti-MRSA Activity from Streptomyces platensis TP-A0598. (2002)

In screening for anti-MRSA antibiotics, novel lydicamycin congeners, TPU-0037-A, B, C and D, were isolated from a culture broth of an actinomycete strain. The producing strain, TP-A0598, was isolated from a seawater sample collected in Toyama Bay, Japan, and identified as Streptomyces platensis based on taxonomic characteristics. TPU-0037-A, B, C and D were purified by HP-20 resin, ODS column chromatographies and preparative HPLC, consecutively, and their structures were determined to be 30-demethyllydicamycin, 14,15-dehydro-8-deoxylydicamycin, 30-demethyl-8-deoxylydicamycin and 8-deoxylydicamycin, respectively, by NMR and MS analyses. The new congeners showed antibiotic activity against gram-positive bacteria including MRSA with the MIC of 1.56 to approximately 12.5 microg/ml.
Control of acoustic absorption in one-dimensional scattering by resonant scatterers (2015)

We experimentally report perfect acoustic absorption through the interplay of the inherent losses and transparent modes with high Q factor. These modes are generated in a two-port, one-dimensional waveguide, which is side-loaded by isolated resonators of moderate Q factor. In symmetric structures, we show that in the presence of small inherent losses, these modes lead to coherent perfect absorption associated with one-sided absorption slightly larger than 0.5. In asymmetric structures, near perfect one-sided absorption is possible (96%) with a deep sub-wavelength sample (λ/28, where λ is the wavelength of the sound wave in the air). The control of strong absorption by the proper tuning of the radiation leakage of few resonators with weak losses will open possibilities in various wave-control devices.
The Relation between the incident neutrino energy spectrum and fundamental parameters for the neutrino oscillation (2005)

In the sense of the tradtional cosmic ray physics, the effective detection for the exsistence of the neutrino oscillation is reduced to the effective recognition for the incident neutrino energy spectrum with the neutrino oscillation. We discuss the relation between the incident neutrino energy spectrum and fundamental parameters through the analysis of the neutrino events occurred outside detector obtained by the computer numerical experiment.
Intracellular pH of Tissue-Cultured Bovine Corneal Endothelial Cells (1992)

Intracellular pH (pHi) of bovine tissue-cultured corneal endothelial cells has been measured under several experimental conditions. Determinations were made on individual cells using video-imaging techniques that allowed assessment of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein fluorescence at 440 and 490 nm. Each experiment had a calibration performed on a cell monolayer: this was performed using a high K(+)-nigericin solution. Resting pHi was 7.25 +/- 0.03 (n = 18) in bicarbonate solution at pH 7.4. Amiloride (1 mM) caused an acidification of approximately 0.2 U within 2 min: replacement with normal Ringer allowed a return to normal pHi after an alkali overshoot. Exposure to 20 mM NH4Cl caused alkalinization that became acidic upon washout of NH4Cl. In Na(+)-rich solution pHi returned to normal after acidification but pHi remained low in Na(+)-free solution until substituted by Na(+)-rich solution. Removal of HCO3- from the bathing solution caused a nonsignificant acidification of pHi by 0.1 U at 2 and 4 min, and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS; 1 mM) acidified pHi by 0.14 U at 2 min and 0.24 U at 4 min. Addition of DIDS (1 mM) in a HCO3(-)-free solution had no effect on pHi. Hydrogen peroxide acidified pHi by 0.3 U at 50 microM and 1 mM. These results indicate that a Na+:H+ antiport exists that regulates pHi even at normal ambient pH in the presence of bicarbonate: this process becomes highly activated after an acid load. There is a DIDS-sensitive HCO3- movement that is probably coupled to Na+ or Cl-.
GeoDeepDive (2013)

We describe our proposed demonstration of GeoDeepDive, a system that helps geoscientists discover information and knowledge buried in the text, tables, and figures of geology journal articles. This requires solving a host of classical data management challenges including data acquisition (e.g., from scanned documents), data extraction, and data integration. SIGMOD attendees will see demonstrations of three aspects of our system: (1) an end-to-end system that is of a high enough quality to perform novel geological science, but is written by a small enough team so that each aspect can be manageably explained; (2) a simple feature engineering system that allows a user to write in familiar SQL or Python; and (3) the effect of different sources of feedback on result quality including expert labeling, distant supervision, traditional rules, and crowd-sourced data.
Blindly Signed Contracts: Anonymous On-Blockchain and Off-Blockchain Bitcoin Transactions. (2016)

Although Bitcoin is often perceived to be an anonymous currency, research has shown that a user’s Bitcoin transactions can be linked to compromise the user’s anonymity. We present solutions to the anonymity problem for both transactions on Bitcoin’s blockchain and off the blockchain (in so called micropayment channel networks). We use an untrusted third party to issue anonymous vouchers which users redeem for Bitcoin. Blind signatures and Bitcoin transaction contracts (aka smart contracts) ensure the anonymity and fairness during the bitcoin ↔ voucher exchange. Our schemes are practical, secure and anonymous.
Optimization of growth conditions for the OMVPE grown InAsP/InP quantum well (2002)

We have investigated the optical quality of a InAsP/InP single quantum well with a 40 /spl Aring/ well thickness grown by organo metallic vapor phase epitaxy at various growth conditions such as growth temperature, V/III ratio, and growth rate, using room temperature photoluminescence (PL) and high resolution X-ray diffraction. The full width at half maximum of PL peaks always increases with the increase of As composition regardless of the growth conditions. However, we observe several different behaviors of PL peak broadening depending on the growth conditions. This different behavior is well described as a function of AsH/sub 3/ flow rate. Based upon our results, we suggest that relatively low growth temperature and low V/III ratio are suitable for the growth of high quality InAsP/InP quantum well structure.