gebhart/patrepeval huggingface dataset:
Somatostatin Receptor Expression in Rat Iliac Arteries After Balloon Injury (1997)

Somatostatin is a general inhibitory hormone that exerts its effects through five functionally distinct receptor subtypes (SSTR1-5). Somatostatin analogues have been shown to be effective in inhibiting intimal hyperplasia after balloon induced vascular injury. However, the exact SSTR subtype responsible for the inhibitory effect of somatostatin on intimal hyperplasia is unknown. The purpose of this study was to define the presence and abundance of SSTR subtypes in a rat iliac balloon injury model of intimal hyperplasia. Transaortic balloon injury of the rat iliac artery was carried out. Rats were sacrificed at 48 h, 1 week, and 1 month postinjury, and perfusion fixed and stained with antibodies against SSTR2, 3, and 5. SSTR2 was identified on the intimal surfaces of normal and injured vessels. SSTR2 immunoreactivity was more prominent at 1 week and 1 month postinjury compared with 48 h postinjury. There was no immunostaining with SSTR3 and SSTR5 antibodies. The results show that SSTR2 is expressed on endothelial cells in normal and injured rat vessels. Its abundance in the injured vessel was increased up to 1 month postinjury.
The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor function (2004)

In vertebrate hemostasis, factor Va serves as the cofactor in the prothrombinase complex that results in a 300,000-fold increase in the rate of thrombin generation compared with factor Xa alone. Structurally, little is known about the mechanism by which factor Va alters catalysis within this complex. Here, we report a crystal structure of protein C inactivated factor Va (A1.A3-C1-C2) that depicts a previously uncharacterized domain arrangement. This orientation has implications for binding to membranes essential for function. A high-affinity calcium-binding site and a copper-binding site have both been identified. Surprisingly, neither shows a direct involvement in chain association. This structure represents the largest physiologically relevant fragment of factor Va solved to date and provides a new scaffold for the future generation of models of coagulation cofactors.
Cationized Bowman-Birk Protease Inhibitor as a Targeted Cancer Chemopreventive Agent (1993)

The conjugate of the Bowman-Birk inhibitor (BBI) with poly(D-lysine) (PDL-ss-BBI) has been suggested as a lung-targeted anti-carcinogenic agent. The authors demonstrate that PDL-ss-BBI, given i.p., reduces the tumor number in the lungs of 3-methylcholanthrene treated mice (61-71% compared to control group) in a dose-dependent manner, but is toxic to the treated animals at a high dosage. In order to develop a better lung-targeted anti-carcinogenic agent, spermine-conjugated BBI (spermine-BBI) was synthesized by coupling BBI to spermine through amide bonds using a carbodiimide-mediated reaction. Results from in vitro transformation assays demonstrated that spermine-BBI was at least as effective as BBI in reducing the transformation yield in C3H10T1/2 cells. When injected intravenously into mice [125I]spermine-BBI accumulated to a greater extent in the lungs and the liver compared to BBI. The in vitro cytotoxicity of spermine-BBI in C3H10T1/2 cells was 30-fold less than that of PDL-ss-BBI. These results suggest that spermine-BBI is likely to be an improved cancer chemopreventive agent compared to BBI or PDL-ss-BBI.
Entstehung und Rolle der Friedens- und Konfliktforschung im Wissenschaftssystem (2011)

Friedens- und Konfliktforschung hat sich in vielen Ländern seit den 1950er Jahren als eine eigenständige interdisziplinäre Forschungsrichtung mit eigenen wissenschaftlichen Kommunikationseinrichtungen wie universitären und außeruniversitären Instituten, Zeitschriften, Fachverbänden und regelmäßigen Konferenzen etabliert (Wasmuht 1998). Sie ist allerdings nach überwiegender Auffassung keine eigenständige Wissenschaftsdisziplin, die durch einen bestimmten, nur ihr eigentümlichen Gegenstand und bestimmte Forschungsmethoden gekennzeichnet ist. Forschung über Frieden und Konflikt wird vielmehr in zahlreichen, vor allem sozialwissenschaftlichen Disziplinen betrieben.
Study of the structure and curing of thiourethane elastomers based on oligomer compositions (2012)

Data on the structure formation of thiourethane elastomers based on oligo(diene diols) and polysulfide oligomers are generalized. The curing of oligo(diene diols) by polyfunctional isocyanates in the presence of liquid thiokols and glycerol is characterized by the formation of highly branched molecules already at the early stages of structure formation. This feature predetermines the microheterogeneous character of the process and the appearance of the gel fraction at low conversions of functional groups. The maximum values of the curing rate and crosslink density are achieved at NCO: (OH + SH) = 1.
MAGNETIC STUDIES OF THE SEMICONDUCTOR TO METAL TRANSITIONS IN Ti3O5 AND Ti2O3 (1966)

Magnetic susceptibility studies show a semiconductor to metal transition in Ti3O5 and Ti2O3. The transition in Ti2O3 is a noncooperative transition as previously observed. An apparent second noncooperative effect is observed at 800°K. The transition in Ti3O5 occurs at around 460°K. It is a distinct cooperative transition and is associated with a phase change. The metallic conduction is believed to occur along the b direction. Some aspects of the theories of Goodenough and Mott are applied to the transitions.
Transcriptional regulatory sequences from plant viruses (1986)

Abstract Two groups of plant viruses have DNA in their genomes. One group, the caulimoviruses, are non‐integrating retroviruses that package dsDNA in virions. The other group, the geminiviruses, package small circular ssDNA and include the only DNA viruses known with bipartite genomes. The regulation of transcription of these viruses is not well characterized, but recent work is beginning to yield interesting results. Regulatory sequences from these viruses function in cells of species that are not hosts of the virus and are finding use in constitutive expression of chimeric genes in transformed plants. Development of vectors based on plant viruses requires further characterization at the molecular level of viral life cycles.
Phase 1 Study of Lumiliximab with Detailed Pharmacokinetic and Pharmacodynamic Measurements in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (2007)

Treatment with lumiliximab seemed to be well tolerated and to have clinical activity in patients with relapsed or refractory CLL.
<title>Image resampling in remote sensing and image visualization applications</title> (1991)

Imaging applications often require image warping in order to obtain a desired spatial effect. In implementing a warping technique, means for transforming and resampling the source data must be chosen. A forward or reverse transformation mapping can be selected, though interpolation is more accurate using the reverse format. When applying a noninvertible transformation, forward mapping becomes necessary. A technique called bin mapping introduces an intermediate storage mechanism which allows for precise interpolation while applying a forward transformation.
Defective recognitive immunity in family aggregates of colon carcinoma. (1977)

Cancer-free individuals from family agregates of seemingly hereditary colon carcinoma were studied to determine the nature of their cell-mediated immune capacities in miexed leukocyte culture. Members of families who demonstrated no evidence of a precancerous condition such as polyposis coli did demonstrate substantial cellular immunopathology. Of these, 44% showed a decreased responsiveness of their peripheral mononuclear cells to allogeneic stimuli, and in a number of these individuals this deficiency clearly manifested itself as an inappropriate suppression of potentially normal lymphocyte blastogenic capacities by an adherent population of mononuclear leukocytes. This in vitro defect of recognitive immunity appears to be the same type of defect that has already been described for individuals with established maligancies. The pattern of phenotypic expression of this immunopathology within these families is not inconsistent with an hereditary disorder. Individuals from families with a known hereditary somatic precancerous condition usually did not demonstrate this immunopathology. It is appropriate to speculate that the defect of recognitive immunity in the former families could be contributory to the genesis of the colon carcinoma.
Dynamic texture synthesis for H.264/AVC inter coding (2008)

Dynamic textures are sequences of frames exhibiting certain stationarity properties over time; examples are sea-waves, whirlwind or moving crowds. We present an algorithm for dynamic texture extrapolation using only few training frames. A dynamic texture synthesizer using this algorithm has been integrated into a state-of-the-art H.264/AVC coding system, such that synthesized frames can be used by the encoder and decoder for inter prediction. For sequences not containing dynamic textures the same performance as with the conventional encoding system was achieved. In the case of sequences containing dynamic textures, intra coded macroblocks can be avoided by using the synthesized frame. Bitrate savings of up to 10% have been observed experimentally.
A guided tour of computer vision (1993)

An introduction to computer vision, covering the structure and properties of the visual world. This concise guide stresses fundamental concepts, and also provides details and pointers with respect to recent developments. The author pursues the narrow view of vision covering the structure and properties of the visual world, thereby providing a lucid introduction for the novice and a fresh perspective to the expert.
A security domain isolation and data exchange system based on VMM (2009)

This paper discusses the network gatekeeper technology, and proposes a security domain isolation and data exchange model based on virtual machine monitor (VMM). Then we give up an implement framework of this model based on XEN. Finally, we discuss the security feature and the future appliance effect of the model.
Hyperbranched Self-Immolative Polymers (<i>h</i>SIPs) for Programmed Payload Delivery and Ultrasensitive Detection (2015)

Upon stimuli-triggered single cleavage of capping moieties at the focal point and chain terminal, self-immolative dendrimers (SIDs) and linear self-immolative polymers (l-SIPs) undergo spontaneous domino-like radial fragmentation and cascade head-to-tail depolymerization, respectively. The nature of response selectivity and signal amplification has rendered them a unique type of stimuli-responsive materials. Moreover, novel design principles are required for further advancement in the field of self-immolative polymers (SIPs). Herein, we report the facile fabrication of water-dispersible SIPs with a new chain topology, hyperbranched self-immolative polymers (hSIPs), by utilizing one-pot AB2 polycondensation methodology and sequential postfunctionalization. The modular engineering of three categories of branching scaffolds, three types of stimuli-cleavable capping moieties at the focal point, and seven different types of peripheral functional groups and polymeric building blocks affords both structurally and functionally diverse hSIPs with chemically tunable amplified-release features. On the basis of the hSIP platform, we explored myriad functions including visible light-triggered intracellular release of peripheral conjugated drugs in a targeted and spatiotemporally controlled fashion, intracellular delivery and cytoplasmic reductive milieu-triggered plasmid DNA release via on/off multivalency switching, mitochondria-targeted fluorescent sensing of H2O2 with a detection limit down to ∼20 nM, and colorimetric H2O2 assay via triggered dispersion of gold nanoparticle aggregates. To further demonstrate the potency and generality of the hSIP platform, we further configure it into biosensor design for the ultrasensitive detection of pathologically relevant antigens (e.g., human carcinoembryonic antigen) by integrating with enzyme-mediated cycle amplification with positive feedback and enzyme-linked immunosorbent assay (ELISA).
Pt Schottky contacts to n-(Ga,Mn)N (2002)

The Schottky barrier height of Pt contacts on n-(Ga,Mn)N (n∼3.5×1017 cm−3) thin films was obtained from current–voltage measurements as a function of temperature. The resulting values ranged from 0.82±0.04 eV at 25 °C to 0.79±0.06 eV at 100 °C with saturation current densities of 4.28×10−8 A cm−2 (25 °C) to 8.42×10−5 A cm−2 (100 °C), respectively. The barrier height at room temperature obtained from an activation energy plot was 0.91±0.06 eV. The reverse current magnitude was larger than predicted by thermionic emission alone, just as in n-GaN grown in a similar fashion on Al2O3 substrates. The measured barrier height for Pt on n-(Ga,Mn)N is lower than for the value reported on n-GaN(1.08 eV).
Molar fraction and substrate orientation effects on carbon doping in InGaAs grown by solid source molecular beam epitaxy using carbon tetrabromide (1998)

Carbon incorporation in InGaAs and GaAs is systematically studied in solid-source molecular beam epitaxy (MBE) as a function of carbon tetrabromide pressure, indium molar fraction, and substrate orientation. The maximum attainable free carrier concentration in GaAs and InGaAs lattice matched with InP was 2×1020 cm−3. The etching effect of CBr4 on growth rate reduction, surface morphology, and growth mechanism is clarified. A comparative study of carbon incorporation as function of substrate orientation and polarity was undertaken by the growth of GaAs and In0.53Ga0.47As on (n11)A and B (n=2, 3, 5) and (100) oriented substrates. Free carrier concentration and mobility measurements showed no carbon autocompensation in GaAs but strong amphoteric behavior for In0.53Ga0.47As grown on arsenic terminated planes. Measurement of hole concentration as function of indium molar fraction in InxGa1−xAs shows that carbon tetrabromide can be used as an effective acceptor doping percursor for indium molar fraction x less than 80% in solid-source MBE.
A new technique to minimize the EPROM cell (1978)

This paper presents a new technique to minimize the UV Erasable, Electrically Programmable, Read-Only Memory (EPROM) cell based on N-channel double polysilicon gate MOS. The new technique features a fully self-aligned floating gate structure which reduces the EPROM cell size/bit to almost that of presently most advanced mask ROMs. A new fabrication process and the experimental results for both programming and erasure are presented. The dependence of characteristics on various device parameters are discussed with emphasis on the difference from conventional devices.
The License Plate Recognition System Based on Fuzzy Theory and BP Neural Network (2011)

In different conditions such as light and complex backgrounds, we get some car images, the traditional methods are slow convergence speed and low accuracy. This paper presents a method which applies fuzzy theory to enhance several features of for target. To obtain the license information, we use an improved BP neural network algorithm, by through setting proper numbers of hidden layer of BP network, we can solve the recognition problems of China's automobile license such as characters kinds, the numbers, and confusing. This method can improve the accuracy and efficiency of car license recognition, and enhance the system robustness.
Vascular Adhesion Protein-1: A Cell Surface Amine Oxidase in Translation (2017)

<b><i>Significance:</i></b> Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that oxidates primary amines in a reaction producing also hydrogen peroxide. VAP-1 on the blood vessel endothelium regulates leukocyte extravasation from the blood into tissues under physiological and pathological conditions. <b><i>Recent Advances:</i></b> Inhibition of VAP-1 by neutralizing antibodies and by several novel small-molecule enzyme inhibitors interferes with leukocyte trafficking and alleviates inflammation in many experimental models. Targeting of VAP-1 also shows beneficial effects in several other diseases, such as ischemia/reperfusion, fibrosis, and cancer. Moreover, soluble VAP-1 levels may serve as a new prognostic biomarker in selected diseases. <b><i>Critical Issues:</i></b> Understanding the contribution of the enzyme activity-independent and enzyme activity-dependent functions, which often appear to be mediated by the hydrogen peroxide production, in the VAP-1 biology will be crucial. Similarly, there is a pressing need to understand which of the VAP-1 functions are regulated through the modulation of leukocyte trafficking, and what is the role of VAP-1 synthesized in adipose and smooth muscle cells. <b><i>Future Directions:</i></b> The specificity and selectivity of new VAP-1 inhibitors, and their value in animal models under therapeutic settings need to be addressed. Results from several programs studying the therapeutic potential of VAP-1 inhibition, which now are in clinical trials, will reveal the relevance of this amine oxidase in humans.
Culture and Poverty Editors' Introduction (1997)

Research Article| October 01 1997 Culture and Poverty Editors' Introduction Adina Back; Adina Back Search for other works by this author on: This Site Google Kevin P. Murphy Kevin P. Murphy Search for other works by this author on: This Site Google Radical History Review (1997) 1997 (69): 1–5. https://doi.org/10.1215/01636545-1997-69-1 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Adina Back, Kevin P. Murphy; Culture and Poverty Editors' Introduction. Radical History Review 1 October 1997; 1997 (69): 1–5. doi: https://doi.org/10.1215/01636545-1997-69-1 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter Books & JournalsAll JournalsRadical History Review Search Advanced Search The text of this article is only available as a PDF. 1997 Article PDF first page preview Close Modal Issue Section: Editor's Introduction You do not currently have access to this content.
Ocular Pulse Amplitude in Healthy Subjects as Measured by Dynamic Contour Tonometry (2006)

The OPA readings obtained with dynamic contour tonometry in healthy subjects are not influenced by the structure of the anterior segment of the eye but are affected by intraocular pressure and axial length. We found a high amount of agreement within and between observers.
A filtered back EMF based speed-sensorless induction motor drive (2002)

Previous works on back EMF based speed-sensorless induction motor drives generally adopt the MRAS approach, frequently contain model redundancy, and can become unstable in the regenerative mode due to lack of adequate stability analysis and a suitable design method. In this paper, a novel back EMF based speed estimation using an adaptive observer is proposed. Explicit stability conditions are then derived from the stability analysis, based on which a design strategy for the speed estimator is introduced to guarantee the stability for the whole operating conditions including the regenerating mode. The implementation complexity is minimized by the integration of the proposed observer with the vector controller to avoid model redundancy. The feasibility of the proposed system is verified by experiment.
<i>In situ</i>expression and significance of B7 costimulatory molecules within tissues of human gastric carcinoma (2003)

ICOS-B7H costimulatory pathway may be predominant at the site of gastric carcinoma. B7-1mRNA might be the basis of ICOS-B7H interaction. ICOS-B7H interaction induces the production of IL-10 which inhibits the antitumor immune responses. Therefore, it is supposed that ICOS-B7H costimulatory pathway may be involved in the negative regulation of cell-mediated immune responses.
Mercer Kernels and Integrated Variance Experimental Design: Connections Between Gaussian Process Regression and Polynomial Approximation (2016)

This paper examines experimental design procedures used to develop surrogates of computational models, exploring the interplay between experimental designs and approximation algorithms. We focus on two widely used approximation approaches, Gaussian process (GP) regression and nonintrusive polynomial approximation. First, we introduce algorithms for minimizing a posterior integrated variance (IVAR) design criterion for GP regression. Our formulation treats design as a continuous optimization problem that can be solved with gradient-based methods on complex input domains without resorting to greedy approximations. We show that minimizing IVAR in this way yields point sets with good interpolation properties and that it enables more accurate GP regression than designs based on entropy minimization or mutual information maximization. Second, using a Mercer kernel/eigenfunction perspective on GP regression, we identify conditions under which GP regression coincides with pseudospectral polynomial approximation. Departures from these conditions can be understood as changes either to the kernel or to the experimental design itself. We then show how IVAR-optimal designs, while sacrificing discrete orthogonality of the kernel eigenfunctions, can yield lower approximation error than orthogonalizing point sets. Finally, we compare the performance of adaptive GP regression and adaptive pseudospectral approximation for several classes of target functions, identifying features that are favorable to the GP + IVAR approach.
TCR‐engineered T cells: A model of inducible TCR expression to dissect the interrelationship between two TCRs (2013)

TCR gene modified T cells for adoptive therapy simultaneously express the Tg TCR and the endogenous TCR, which might lead to mispaired TCRs with harmful unknown specificity and to a reduced function of TCR-Tg T cells. We generated dual TCR T cells in two settings in which either TCR was constitutively expressed by a retroviral promoter while the second TCR expression was regulable by a Tet-on system. Constitutively expressed TCR molecules were reduced on the cell surface depending on the induced TCR expression leading to strongly hampered function. Besides that, using fluorescence resonance energy transfer we detected mispaired TCR dimers and different pairing behaviors of individual TCR chains with a mutual influence on TCR chain expression. The loss of function and mispairing could not be avoided by changing the TCR expression level or by introduction of an additional cysteine bridge. However, in polyclonal T cells, optimized TCR formats (cysteineization, codon optimization) enhanced correct pairing and function. We conclude from our data that (i) the level of mispairing depends on the individual TCRs and is not reduced by increasing the level of one TCR, and (ii) modifications (cysteineization, codon optimization) improve correct pairing but do not completely exclude mispairing (cysteineization).
Field evaluation of three plant-based insect repellents against malaria vectors in Vaca Diez Province, the Bolivian Amazon. (2002)

The efficacy of repellents against Anopheles darlingi, the main malaria vector in Bolivia, was evaluated. This mosquito has a peak in biting activity early in the evening. Three natural repellents (1 eucalyptus based, 1 neem based, and 1 containing several repellent essential oils) were tested in comparison with 15% deet in human landing catches in Bolivia. The eucalyptus-based repellent containing 30% p-menthane-diol applied at a dose similar to those used in practice gave 96.89% protection for 4 h. Deet gave 84.81% protection. The other 2 products did not provide significant protection from mosquito bites.