gebhart/patrepeval huggingface dataset:
Polyglutamine disease: Recent advances in the neuropathology of dentatorubral‐pallidoluysian atrophy (2006)

Polyglutamine diseases are hereditary neurodegenerative disorders that are caused by the expansion of a CAG repeat in the causative genes. They comprise at least nine disorders, including DRPLA, HD, and Machado-Joseph disease. Initially, the discovery of neuronal intranuclear inclusions (NIIs) in human brains and in a murine model of HD provided a plausible hypothesis that the expression of expanded polyglutamine stretches leads to NII formation, resulting in neuronal cell death in selective brain regions characteristic to each disease. Recent studies, however, suggest that nuclear dysfunction, especially transcriptional abnormalities caused by the diffuse intranuclear accumulation of mutant proteins, plays a pivotal role in the development and progression of clinical symptoms. Polyglutamine diseases have a similarity with neuronal storage disease, and this pathological process might become a target for the establishment of an effective therapy for these diseases.
Indoor cooperative small cells over ethernet (2013)

The ubiquitous Ethernet has great potential to become an easy-to-install cost-effective backhaul solution for mobile small cells. However, limited Ethernet bandwidth is a practical constraint. Not only is small cell capacity limited by Ethernet bandwidth, but also the synchronization between cells can be substantially compromised. In this article we discuss small cells with Ethernet backhaul, focusing on two practical and important aspects: backhaul bandwidth requirements and tolerance to synchronization errors. The aspects become challenging in indoor small cell applications where the cells need to cooperatively suppress strong interference, producing a large amount of backhaul traffic. To address the challenges, we introduce a new distributed scheme of cooperative small cells over Ethernet. Exploiting a soft information combining technique, the scheme allows the signals of cooperative cells to be combined at aggregate switches along their backhaul paths, reducing backhaul traffic in Ethernet and distributing computational complexity. Our case study shows that the distributed scheme can reduce small cell backhaul traffic by 64 percent, compared to a conventional centralized approach. It is also tolerant to a large frequency error of ±4.6 ppm in a freerun state where synchronization is lost. Given the substantially reduced backhaul traffic, the new distributed scheme is able to support three times the cooperative small cells of the conventional centralized approach.
Wavelength-Dependent Change of Retinal Nerve Fiber Layer Reflectance in Glaucomatous Retinas (2012)

Elevation of intraocular pressure (IOP) causes nonuniform changes in RNFL reflectance across wavelengths. Changes of reflectance spectra occur early in bundles near the ONH and prior to apparent cytoskeletal distortion. Using the ratio of RNFL reflectance measured at different wavelengths can provide early and sensitive detection of glaucomatous damage.
Network delay analysis of a class of fair queueing algorithms (1995)

A self-clocked fair queueing (SCFQ) scheme has been proposed by Golestani (see Proc. IEEE INFOCOM, p. 636-636, 1994) as an easily implementable version of fair queueing. In this paper, the worst case network delay performance of a class of fair queueing algorithms, including the SCFQ scheme, is studied. We build upon and generalize the methodology developed by Parekh and Gallager (see ACM/IEEE Trans. Networking, vol.1, no.3, p.344-357, 1993, and vol.2, no.2, p.137-150, 1994) to study this class of algorithms based on the leaky-bucket characterization of traffic. Under modest resource allocation conditions, the end-to-end session delays and backlogs corresponding to this class of algorithms are shown to be bounded. For the SCFQ scheme, these bounds are larger, but practically as good as the corresponding bounds for the PGPS scheme. It is shown that the SCFQ scheme can provide adequate performance guarantees for the delay-sensitive traffic in ATM.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Partitioning Low-Diameter Networks to Eliminate Inter-Job Interference (2017)

On most supercomputers, except some torus network based systems, resource managers allocate nodes to jobs without considering the sharing of network resources by different jobs. Such network-oblivious resource allocations result in link sharing among multiple jobs that can cause significant performance variability and performance degradation for individual jobs. In this paper, we explore low-diameter networks and corresponding node allocation policies that can eliminate inter-job interference. We propose a variation to n-dimensional mesh networks called express mesh. An express mesh is denser than the corresponding mesh network, has a low diameter independent of the number of routers, and is easily partitionable. We compare structural properties and performance of express mesh with other popular low-diameter networks. We present practical node allocation policies for express mesh and fat-tree networks that not only eliminate inter-job interference and performance variability, but also improve overall performance.
Stereoscopic segmentation (2002)

We cast the problem of multiframe stereo reconstruction of a smooth shape as the global region segmentation of a collection of images of the scene. Dually, the problem of segmenting multiple calibrated images of an object becomes that of estimating the solid shape that gives rise to such images. We assume that the radiance has smooth statistics. This assumption covers Lambertian scenes with smooth or constant albedo as well as fine homogeneous textures, which are known challenges to stereo algorithms based on local correspondence. We pose the segmentation problem within a variational framework, and use fast level set methods to approximate the optimal solution numerically. Our algorithm does nor work in the presence of strong textures, where traditional reconstruction algorithms do. It enjoys significant robustness to noise under the assumptions it is designed for.
Stability Analysis of Chatter in Tandem Rolling Mills—Part 1: Single- and Multi-Stand Negative Damping Effect (2013)

Many different modes of chatter in rolling and their possible causes have been identified after years of research, yet no clear and definite theory of their mechanics has been fully established and accepted. In this two-part paper, stability of tandem mills is investigated. In Part 1, state-space models of single- and multi-stand chatter are formulated in a rigorous and comprehensive mathematical form. Then, the stability of the rolling system is investigated in the sense of the single- and multi-stand negative damping effects. First, a single-stand chatter model in state-space representation is proposed by coupling a dynamic rolling process model with a structural model for the mill stand. Subsequently, a multi-stand chatter model is developed by incorporating the inter-stand tension variations and the time delay effect of the strip transportation based on the single-stand chatter model. Stability criteria are proposed and stability analyses are performed to create corresponding stability charts in terms of the single- and multi-stand negative damping mechanism through numerical simulations. Particularly, the effect of friction conditions on chatter is examined and an explanation is given for the existence of an optimum friction condition. In Part 2, the regenerative effect and resulting instabilities are examined. Suitable stability criteria for each mechanism are established and stability charts are demonstrated in terms of relevant rolling process parameters.
ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome (2020)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged in Chinese people in December 2019 and has currently spread worldwide causing the COVID-19 pandemic with more than 150,000 deaths. In order for a SARS-CoV like virus circulating in wild life for a very long time to infect the index case-patient, a number of conditions must be met, foremost among which is the encounter with humans and the presence in homo sapiens of a cellular receptor allowing the virus to bind. Recently it was shown that the SARS-CoV-2 spike protein, binds to the human angiotensin I converting enzyme 2 (ACE2). This molecule is a peptidase expressed at the surface of lung epithelial cells and other tissues, that regulates the renin-angiotensin-aldosterone system. Humans are not equal with respect to the expression levels of the cellular ACE2. Moreover, ACE2 polymorphisms were recently described in human populations. Here we review the most recent evidence that ACE2 expression and/or polymorphism could influence both the susceptibility of people to SARS-CoV-2 infection and the outcome of the COVID-19 disease. Further exploration of the relationship between the virus, the peptidase function of ACE2 and the levels of angiotensin II in SARS-CoV-2 infected patients should help to better understand the pathophysiology of the disease and the multi-organ failures observed in severe COVID-19 cases, particularly heart failure.
Reduced Vibroseis cycle time technique increases land crew productivity (2005)

There are still many challenges in improving land seismic productivity. Here Jean-Jacques Postel*, Julien Meunier and Thomas Bianchi describe a new technique for achieving more effective Vibroseis data acquisition. As oil companies come to expect increasingly detailed knowledge of their reservoirs, demand for ever larger seismic volumes is escalating. Land seismic recorder manufacturers have accommodated this trend by improving equipment reliability and by increasing exponentially the number of channels available in the field. The Vibroseis source, however, remains the weak link in the acquisition chain and represents the bottleneck in production. Better source productivity will be key to meeting oil company demand and CGG has been addressing this issue with the development of a new technique.
R1 and R2 Retrotransposition and Deletion in the rDNA Loci on the X and Y Chromosomes of <i>Drosophila melanogaster</i> (2003)

The non-LTR retrotransposons R1 and R2 insert into the 28S rRNA genes of arthropods. Comparisons among Drosophila lineages have shown that these elements are vertically inherited, while studies within species have indicated a rapid turnover of individual copies (elimination of old copies and the insertion of new copies). To better understand the turnover of R1 and R2, 200 retrotranspositions and nearly 100 eliminations have been scored in the Harwich mutation-accumulation lines of Drosophila melanogaster. Because the rDNA arrays in D. melanogaster are present on the X and Y chromosomes and no exchanges were detected in these lines, it was possible to show that R1 retrotranspositions occur predominantly in the male germ line, while R2 retrotranspositions were more evenly divided between the germ lines of both sexes. The rate of elimination of elements from the Y rDNA array was twice that of the X rDNA array with both chromosomal loci containing regions where the rate of elimination was on average eight times higher. Most R1 and R2 eliminations appear to occur by large intrachromosomal events (i.e., loop-out events) that involve multiple rDNA units. These findings are interpreted in light of the known abundance of R1 and R2 elements in the X and Y rDNA loci of D. melanogaster.
Local Delivery of Molecules from a Nanopipette for Quantitative Receptor Mapping on Live Cells (2013)

Using nanopipettes to locally deliver molecules to the surface of living cells could potentially open up studies of biological processes down to the level of single molecules. However, in order to achieve precise and quantitative local delivery it is essential to be able to determine the amount and distribution of the molecules being delivered. In this work, we investigate how the size of the nanopipette, the magnitude of the applied pressure or voltage, which drives the delivery, and the distance to the underlying surface influences the number and spatial distribution of the delivered molecules. Analytical expressions describing the delivery are derived and compared with the results from finite element simulations and experiments on delivery from a 100 nm nanopipette in bulk solution and to the surface of sensory neurons. We then developed a setup for rapid and quantitative delivery to multiple subcellular areas, delivering the molecule capsaicin to stimulate opening of Transient Receptor Potential Vanilloid subfamily member 1 (TRPV1) channels, membrane receptors involved in pain sensation. Overall, precise and quantitative delivery of molecules from nanopipettes has been demonstrated, opening up many applications in biology such as locally stimulating and mapping receptors on the surface of live cells.
Proteins containing only half of the coding information of early region 1b of adenovirus are functional in human cells transformed with the herpes simplex virus type 1 thymidine kinase gene and adenovirus type 2 DNA (1982)

We introduced into tk- human 143 cells adenovirus type 2 (Ad2) genes by transformation with a plasmid (p711) containing both Ad2 sequences and the herpes simplex virus type 1 (HSV-1) tk gene. p711 contained approximately the left 8% of the Ad2 genome inserted in the HindIII site of pBR322, whereas the fragment of HSV-1 containing the tk gene was inserted in the BamHI site. Three tk+ cell lines were isolated after selection in HAT medium. The arrangement of viral sequences in the three transformants was analyzed by restriction endonuclease digestion and filter hybridization. All three lines contained a single insertion of Ad2 DNA which was present at approximately one copy per cell. The arrangement of Ad2 sequences in these lines was identical to that found in the linear p711 DNA used in the transformation. S1 analysis of the Ad2-specified RNA from two of these lines indicated that the early region 1a mRNA's were synthesized, though in lower amounts than found in lytic infections. These cell lines contained only the left half of early region 1b (4.6 to 11.2), which encoded the 5' portion of the 1b mRNA's. A complex pattern of 1b RNAs was made in these cell lines. Transcription of most of these RNAs began at or near the 1b promoter and proceeded through the 1b sequences into the flanking pBR322, HSV-1, or host sequences. Since many of the RNAs were terminated or spliced in the HSV-1 (anti-sense strand) or pBR322 sequences, new RNA processing sites must be used in the formation of these mRNA's. All three lines fully complemented the 1a deletion mutant Ad5 dl312. Surprisingly, these lines also permitted the growth of 1b deletion mutants (Ad5 dl313 and Ad5 dl434), although the complementation was not always complete. Presumably the new gene product(s) which contained only part of the 1b gene provided most of the essential function(s) required for viral multiplication. Alternatively, the 1b 19-kilodalton protein which was entirely encoded by the adenovirus sequences present in these cell lines was sufficient for viral growth even in the absence of the 1b 55-kilodalton protein.
Studies on the kinetics of<b><i>in situ</i></b>epoxidation of vegetable oils (2008)

Abstract In the present work, the kinetics of the epoxidation of soybean oil (SBO) by peroxyacetic acid (PAA) generated in situ in the presence of sulfuric acid as the catalyst was studied at various temperatures (45, 65 and 75 °C). It was found that epoxidation with almost complete conversion of unsaturated carbon and negligible oxirane cleavage can be attained by the in situ technique. The rate constant for epoxidation of SBO was found to be of the order of 10 –6 mol –1 s –1 and the activation energy of epoxidation is 43.11 kJ/mol. Some thermodynamic parameters: enthalpy, entropy and free activation energy of 40.63 kJ/mol, –208.80 J/mol and 102.88 kJ/mol, respectively, were obtained for the epoxidation of SBO. The kinetic and thermodynamic parameters of epoxidation obtained from this study indicate that an increase in the process temperature would increase the rate of epoxide formation. The epoxidation of corn oil and sunflower oil were also investigated under the same conditions. The results show that the reaction rate is in the order of soybean oil > corn oil > sunflower oil.
Transition Metal Mediated <i>Exo </i>Selective Diels−Alder Reactions:  Preparation of 2-Cobalt-Substituted 1,3-Dienes Containing <i>C</i><sub>2</sub> Symmetric 2,3-Dibenzobicyclo[2.2.2]octanedione Dioxime Equatorial Ligands and Their Use in Thermal and Lewis Acid Catalyzed 4 + 2 Cycloadditions (1996)

The preparation of C2 symmetric 2,3-dibenzobicyclo[2.2.2]octanedione dioxime is reported. This ligand is then used in the preparation of a (pyridine)(glyoxime)2cobalt(III) chloride complex. The chloride is reduced to a cobaloxime anion which reacted with allenic electrophiles to produce (pyridine)(glyoxime)2cobalt-1,3-dienyl complexes. Thermal and Lewis acid catalyzed Diels−Alder reactions of these dienyl complexes as well as the complexes with glyoxime = diphenylglyoxime and dimethylglyoxime are reported. In most cases these Diels−Alder reactions are anti (exo) selective, and in many cases diastereoselectivities are >20:1. Cycloadduct demetalation reactions are also reported which preserve cycloaddition stereochemistry and provide cobalt complexes which can be recycled into the starting dienyl complex.
PATERNITY AND HORMONE LEVELS AFTER UNILATERAL CRYPTORCHIDISM: ASSOCIATION WITH PRETREATMENT TESTICULAR LOCATION (2000)

Preoperative testicular location in men with previous unilateral cryptorchidism is not a major determinant of fertility according to paternity, sperm count or hormone levels.
New Ergostane and Lanostane from Antrodia Camphorata (2003)

Fourteen compounds (one biphenyl, six ergostane, and seven lanostane derivatives) have been isolated from the fruiting body of Antrodia camphorata. They are 3β, 15α-dihydroxylanosta-7, 9 (11), 24-trien-21-oic acid, antcin K, dehydroeburicoic acid, eburicoic acid, methyl antcinate B, methyl antcinate H, zhankuic acid A, zhankuic acid B, dehydrosulphurenic acid, sulphurenic acid, 15α-acetyl-dehydrosulphurenic acid, versisponic acid D, zhankuic acid C, and 2, 2', 5, 5'-tetramethoxy-3, 4, 3', 4'-bis (methlylenedioxy) -6, 6'-dimethylbiphenyl. Among them, two lanostane-type compounds-sulphurenic acid and versisponic acid D were not previously reported from this fungus. 3β, 15α-Dihydroxylanosta-7, 9 (11), 24-trien-21-oic acid and antcin K are first found from nature and their structures were determined by spectroscopic methods.
Predictors of Fatal Brain Edema in Massive Hemispheric Ischemic Stroke (2001)

Among patients with large MCA infarctions, an increased risk of fatal brain edema is associated with history of hypertension or heart failure, increased baseline white blood cell count, major early CT hypodensity involving >50% of the MCA territory, and involvement of additional vascular territories. These data confirm and expand on prior research with a broad-based patient population. The presence of these risk factors identifies those stroke patients who may require aggressive therapeutic approaches.
Super high definition image digitizing system (1992)

A very-high-resolution image digitizing system that handles both still and motion images is presented. The system mainly consists of a high-resolution CCD line scanner and high-precision film transport equipment. Resolution characteristics are measured directly using test charts, and resolution of over 2048 pixels is obtained in both the vertical and horizontal direction. Therefore, this system can generate test sequences for super-high-definition images that have at least 2048*2048 pixels. Various corrections, such as shading-, gamma-, and color-correction and edge enhancement, are made, and good reproductions of original photo images are obtained. Sixteen standard images are digitized and prepared for coding simulations and other applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Regulation of expression of two LY-6 family genes by intron retention and transcription induced chimerism (2008)

In conclusion, the LY6G5B and LY6G6D intron-retained transcripts are not subjected to NMD and are more abundant than the properly spliced forms. In addition, these genes form chimeric transcripts with their neighbouring same orientation 5' genes. Of interest is the fact that the 5' genes (CSNKbeta or G6F) undergo differential splicing only in the context of the chimera (CSNKbeta-LY6G5B or G6F-LY6G6C) and not on their own.
Blue Copper Model Complexes with Distorted Tetragonal Geometry Acting as Effective Electron-Transfer Mediators in Dye-Sensitized Solar Cells (2005)

The electron self-exchange rate constants of blue copper model complexes, [(-)-sparteine-N,N'](maleonitriledithiolato-S,S')copper ([Cu(SP)(mmt)])(0/)(-), bis(2,9-dimethy-1,10-phenanthroline)copper ([Cu(dmp)(2)](2+/+)), and bis(1,10-phenanthroline)copper ([Cu(phen)(2)](2+/+)) have been determined from the rate constants of electron transfer from a homologous series of ferrocene derivatives to the copper(II) complexes in light of the Marcus theory of electron transfer. The resulting electron self-exchange rate constant increases in the order: [Cu(phen)(2)](2+/+) < [Cu(SP)(mmt)](0/)(-) < [Cu(dmp)(2)](2+/+), in agreement with the order of the smaller structural change between the copper(II) and copper(I) complexes due to the distorted tetragonal geometry. The dye-sensitized solar cells (DSSC) were constructed using the copper complexes as redox couples to compare the photoelectrochemical responses with those using the conventional I(3)(-)/I(-) couple. The light energy conversion efficiency (eta) values under illumination of simulated solar light irradiation (100 mW/cm(2)) of DSSCs using [Cu(phen)(2)](2+/+), [Cu(dmp)(2)](2+/+), and [Cu(SP)(mmt)](0/)(-) were recorded as 0.1%, 1.4%, and 1.3%, respectively. The maximum eta value (2.2%) was obtained for a DSSC using the [Cu(dmp)(2)](2+/+) redox couple under the light irradiation of 20 mW/cm(2) intensity, where a higher open-circuit voltage of the cell was attained as compared to that of the conventional I(3)(-)/I(-) couple.
α2,3-Linked Sialic Acids Are More Abundant in CD45 Antigens and Leukosialins of Abnormal T Cells of lpr Mice than in Those of Normal T Cells1 (1989)

T cells from enlarged lymph nodes of MRL/MpJ−lpr/lpr (lpr) mice were found to express more binding sites for strongly hemagglutinating Phaseolus vulgaris agglutinin (PHA-E4) and fewer binding sites for Ricinus communis agglutinin (RCA) than those from normal MRL/MpJ−+/+ (+/+) mouse lymph node. We found that high-molecular-weight (180K–220K) glycoproteins on lpr T cells were strongly stained with these lectins on Western-blotting. These glycoproteins were found to belong to the CD46 family, by absorption with monoclonal anti-CD46 antibody. We also found that the other glycoproteins (105K and 120K glycoproteins on lpr T cells and a 105K glycoprotein on +/+ T cells) were strongly stained with the lectins which preferentially bind to mucin-type (O-linked) sugar chains on the cell surface. These glycoproteins were found to be leukosialins, by absorption with anti-leukosialin serum. From the results of the lectin-binding to these glycoproteins after sialidase treatment, CD45 antigens and leukosialin molecules on lpr T cells were found to have many more terminal α2, 3-linked sialic acids than those on + /+ T cells, and this fact explains why lpr T cells have more binding sites for PHA-E4 but fewer binding sites for RCA.