gebhart/patrepeval huggingface dataset:
Acute myeloid leukaemia cells secrete a soluble factor that inhibits T and NK cell proliferation but not cytolytic function – implications for the adoptive immunotherapy of leukaemia (2001)

Evidence of an immune mediated graft-versus-leukaemia effect has led to the belief that T and NK cell based adoptive immunotherapy can constitute effective treatment for relapsed leukaemias. However, work on solid tumours has shown this strategy may be hampered, by an immune escape mechanism in which tumour secreted immunosuppressive factors compromise T and NK cell function. Indeed, acute myeloid leukaemia (AML) cells secrete immunosuppressive factors that block the synthesis of Th1 type cytokines in T cells. We demonstrate here that this immunosuppression, mediated by both HL60 AML cell line and primary AML blasts, inhibits T and NK cell proliferation but not cytolytic activity. Supernatants from HL60 cell line and primary AML blasts inhibited T cell proliferation to mitogenic and alloantigen stimulation but had no effect on cytolytic function. Similarly, the proliferation of NK cells to IL-2 and IL-15 stimulation was inhibited whilst their cytolytic function, shown by lysis of AML blasts, K562 and Daudi cells remained unaffected. The failure of T and NK cells to proliferate was not due to effector cell apoptosis. Indeed, removal of lymphocytes from the immunosuppressive environment partially restored their capacity to respond to mitogenic stimulation. T cells exposed to immunosuppressive supernatants did not increase expression of mitotic inhibitory proteins that arrest cell division, thereby ruling this out as a mechanism of operation for this immunosuppression. T cell expansion requires antigen stimulation, usually provided in the form of AML blasts, therefore our data suggest that NK cells may be more practical for the immunotherapy of AML.
Oxytocin enhances onset of lactation among mothers delivering prematurely. (1981)

In a double-blind group sequential trial the efficiency of an oxytocin nasal spray in enhancing lactation was studied during the first five days after delivery in women who had given birth prematurely. The cumulative volume of breast milk obtained between the second and fifth days after delivery was 3.5 times greater in primiparas given oxytocin than in primiparas given placebo. There was no significant difference in the composition of the milk between the untreated women and those given oxytocin. The results of this study show that oxytocin nasal spray is an effective and safe means of enhancing lactation in women using a breast pump.
Dissociation of K channel density and ROMK mRNA in rat cortical collecting tubule during K adaptation (1998)

The density of conducting K channels in the apical membrane of the rat cortical collecting tubule (CCT) is increased by a high-K diet. To see whether this involved increased abundance of mRNA coding for K channel protein, we measured the relative amounts of mRNA for ROMK, the clone of the gene thought to encode the secretory K channel in the CCT. Tubules were isolated and fixed for in situ hybridization with a probe based on the ROMK sequence. Radiolabeled probe associated with the tubule was quantified using densitometric analysis of the autoradiographic images of the tubules. The densitometry signal was shown to be proportional to the amount of radioactive probe in the sample and to the time of exposure of the film. The technique was able to detect an approximately twofold increase in the abundance of mRNA coding for the water channel aquaporin 3 (AQP3), in response to a 30-h dehydration period. Tubules from rats fed a normal diet or a high-K (10% KCl) diet had equal amounts of ROMK mRNA. This suggests that an increase in the abundance of mRNA does not underlie the increase in channel density observed under these conditions.
Sleep Drivers (2020)

Driving while sleepy can have devastating consequences, but it is an under-recognised problem often associated with behavioural factors, medical conditions or medications. All drivers have a responsibility not to drive if sleepy and there are DVLA regulations restricting driving for patients with certain sleep disorders who are at risk of excessive sleepiness at the wheel. However, sleepiness can be difficult for patient and doctor to assess and guidelines open to interpretation. As doctors it is important we give consistent and reliable advice to patients who may be at risk when driving. This review suggests how to assess driving risk, educate patients about risk reduction, and clarifies DVLA guidelines in this area.
Thermally resistant UV-curable epoxy–siloxane hybrid materials for light emitting diode (LED) encapsulation (2012)

A UV-curable epoxy–siloxane hybrid material (epoxy hybrimer) was fabricated by photo-cationic polymerization of a sol–gel derived cyclo-aliphatic epoxy oligosiloxane (CAEO) blended with oxetane cross-linker in the presence of an onium salt. Antioxidants for fabrication of the UV-curable epoxy hybrimer with high thermal resistance against yellowing were incorporated in the UV-curable epoxy hybrimer. The UV-curable epoxy hybrimer with the antioxidants showed high thermal resistance without yellowing during 120 °C thermal aging. High thermal resistance of the UV-curable epoxy hybrimer was similar and higher compared to those of commercial thermally curable silicone and UV-curable epoxy LED encapsulants, respectively. The thermally resistant UV-curable epoxy hybrimer was successfully encapsulated on a LED without any cracking or delamination, and maintained a flat surface on the LED without distortion of the designed flat shape. Before/after thermal and blue light aging, the performance of the LED encapsulated by the UV-curable epoxy hybrimer was not changed. On the basis of its excellent properties as a LED encapsulant, the UV-curable epoxy hybrimer can be utilized as a UV-curable LED encapsulant for white LEDs.
Genome-Wide Association Study for Anthracycline-Induced Congestive Heart Failure (2016)

rs28714259 represents a validated SNP that is associated with anthracycline-induced CHF in three independent, phase III adjuvant breast cancer clinical trials. Clin Cancer Res; 23(1); 43-51. ©2016 AACR.
The Evaluation of the Degree of Applying Risk Management Behaviors among Sports Councils in East of Iran (2012)

The aim of this study is to determine the degree of applying risk management behaviors among managers and directors of sports councils in Khorasan province which is located in the east of Iran. The method was descriptive-analytic, and conducted on all the managers and directors of sports councils. The samples was included 126 managers and directors of sports councils in Khorasan who had been working in the East area (Khorasan). The questionnaire (risk management, Aeron. 2004) was used and Cronbach Alpha was .87 which was satisfactory. Descriptive and inferential statistics (Kruskal Wallis H, Kendall & Pearson), have been used in data analysis. The findings of the research showed that there isn’t any meaningful relationship between levels of education, the employment status, coaching status and risk management behaviors, while there was meaningful relationship between field of education)p? 0.006), coaching experience(p?0.033, r=0.185), managing experience(p?0.001, r= 0.260) and risk management behaviors. As a whole we can say that the level of performance of risk management behaviors among the sports councils in Kuhorsan province has a desirable condition. It was also found that staff directors performed risk management behaviors better than line directors.
SmartFall: An Automatic Fall Detection System Based on Subsequence Matching for the SmartCane (2009)

Fall-induced injury has become a leading cause of death for the elderly. Many elderly people rely on canes as an assis- tive device to overcome problems such as balance disorder and leg weakness, which are believed to have led to many incidents of falling. In this paper, we present the design and th
LXXXV. <i>The echelette grating for the infra-red</i> (1910)

(1910). LXXXV. The echelette grating for the infra-red. The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science: Vol. 20, No. 118, pp. 770-778.
Formation of Al-nitride films at room temperature by nitrogen ion implantation into aluminum (1981)

A new method is demonstrated for the preparation of thin aluminum nitride layers using the direct nitridation aluminum by low-energy nitrogen ion implantation in the ion energy range 0.5-5 keV. The Al-nitride films were obtained at room temperature without any thermal annealing. For the first time Al-nitride was studied with Auger electron spectroscopy (AES) and low-energy electron-loss spectroscopy (ELS) and the corresponding spectra, together with those of Al and Al2O3, are presented. An electron energy-level scheme for Al-nitride was derived from the AlLvv Auger spectra, from the valence electron excitation spectra, and from the Al(2p) and N(ls) core electron excitation spectra measured by ELS.
Automatic on-off switching repeater for DS/CDMA reverse link capacity improvement (2001)

We propose an automatic on-off switching (AOS) repeater that is switched off automatically when there is no active user within its coverage. With the AOS repeater, we can reduce the unnecessary noise enhancement. The reverse link capacity of a DS/CDMA system with AOS repeaters is analyzed mathematically and compared with that of a system with conventional repeaters. Also, the AOS circuit in a repeater can protect the reverse link capacity of a DS/CDMA system from excessive noise enhancement by abnormal repeaters. From the numerical results, noticeable improvement with the AOS repeaters is shown.
EDC/NHS activation mechanism of polymethacrylic acid: anhydride versus NHS-ester (2015)

Both stable intermediates of anhydride and NHS-ester were observed after EDC/NHS activation of PMAA, where NHS-ester waxes, while anhydride wanes complementarily with increasing fragmentation degree of PMAA blocks in PMAA-associated polymer blends.
Estimating human rabies mortality in the United Republic of Tanzania from dog bite injuries. (2002)

In the United Republic of Tanzania, cases of rabies in humans have been greatly underreported. Dog bite injuries are an accessible source of epidemiological data that may be used to estimate the public health burden of rabies and to monitor epidemiological trends in developing countries.
High performance thin crystalline silicon solar cell grown on silicon-on-insulator (2009)

High open circuit voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OC</sub> ) is a potential benefit of thin silicon solar cells. A new thin silicon solar cell structure is proposed using silicon-on-insulator (SOI) technology that investigates the properties of high voltage in thin silicon designs with an epitaxial emitter. Key design parameters are low rear and front surface recombination, low dark current and efficient light trapping. We propose a patterned emitter area on a SOI substrate. The advantages of this design are the passivation properties embedded in the buried oxide and the reduced junction area. With a uniform epitaxial emitter, the top contact shadowing can be designed to be 0%. Preliminary results show V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">oc</sub> > 525 mV and J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Sc</sub> > 20 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> with_anti-reflection coating. This represents a substantial increase from previous work by Danos et al. which reported V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">oc</sub> < 500 mV and J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sc</sub> ~ 0.45 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . This present design also demonstrates the effect of a smaller emitter area and reports higher performance parameters for reported silicon cells fabricated on SOI substrates.
Prediction of Clinicopathologic Response of Breast Cancer to Primary Chemotherapy at Contrast-enhanced MR Imaging: Initial Clinical Results (2006)

Reductions in MR imaging-determined size of the primary tumor best predict clinicopathologic response of breast cancer after one cycle of neoadjuvant chemotherapy. Transfer constant and size changes are equally sensitive in the identification of patients who would gain no clinical or pathologic benefit after two cycles of treatment.
Nonextractable polyphenols, usually ignored, are the major part of dietary polyphenols: A study on the Spanish diet (2010)

Non extractable polyphenols are the major part of dietary polyphenols. The knowledge of intakes and physiological properties of NEPP may be useful for a better understanding of the potential health effects of dietary PP.
Promotion of melanoma growth by the metabolic hormone leptin (2010)

We have previously shown that melanoma cells proliferate in response to the metabolic hormones TRH and TSH. The objective of the present study was to test the hypothesis that a third metabolic hormone, leptin, serves as a growth factor for melanoma. Using western blotting, indirect immunofluorescence, and RT-PCR, leptin receptors were found to be expressed by human melanoma cells. In contrast, cultured melanocytes expressed message for the receptor without detectable protein. Melanoma cells responded to treatment with leptin by activating the MAPK pathway and proliferating. Melanoma cells but not melanocytes, also expressed leptin protein, creating a potential autocrine loop. Examination of human melanoma tumors by immunohistochemistry revealed that melanomas and nevi expressed leptin at a high frequency. Melanomas also strongly expressed the leptin receptor, whereas nevi expressed this receptor to a much lesser degree. We conclude that leptin is a melanoma growth factor and that a leptin autocrine-loop may contribute to the uncontrolled proliferation of these cells.
Intralesional Cryosurgery A New Technique Using Cryoneedles (1993)

A new method for applying cryosurgery in depth has been performed in a trial in order to achieve more effectiveness and avoid many of the disadvantages of conventional techniques. A needle is introduced into the skin from one point and runs through the deeper tissues of the lesion, appearing at the surface on the opposite border. A cryogen is then passed through one end of the needle and vents to the atmosphere from the opposite end. An ice cylinder is formed around the embedded part of the needle within the deeper tissues. The distance of extension of freezing can be estimated by insertion of thermocouple needles as well as by the degree of extension of the whitish ice balls formed around the points of contact between the skin surface and the visible portions of the needle. New varieties of needles have been developed to facilitate improved efficacy in achieving better depth of freeze. The needles are angled, curved, and hook-shaped. Some are partially insulated to better localize the direction of freezing. The process was very practical, and effectively eradicated 85% of epidermal lesions after one freeze; 15% needed additional sessions as did deeper dermal lesions.
A comparative analysis of web and peer-to-peer traffic (2008)

Peer-to-Peer (P2P) applications continue to grow in popularity, and have reportedly overtaken Web applications as the single largest contributor to Internet traffic. Using traces collected from a large edge network, we conduct an extensive analysis of P2P traffic, compare P2P traffic with Web traffic, and discuss the implications of increased P2P traffic. In addition to studying the aggregate P2P traffic, we also analyze and compare the two main constituents of P2P traffic in our data, namely BitTorrent and Gnutella. The results presented in the paper may be used for generating synthetic workloads, gaining insights into the functioning of P2P applications, and developing network management strategies. For example, our results suggest that new models are necessary for Internet traffic. As a first step, we present flow-level distributional models for Web and P2P traffic that may be used in network simulation and emulation experiments.
A new control IC for switched reluctance motor drives (1990)

A new control IC for switched reluctance motor drives is described. The LMB1008 contains all the necessary analog and digital control to drive a switched reluctance motor in both forward and reverse rotation with stepwise-adjustable firing angles. Both motoring and braking modes are provided. The internal commutation logic can operate with shaft position signals derived from either 3 or 2 Hall or optical sensors; or in 'straight-through' mode with no shaft position sensors. For closed-loop speed control an internal tacho (frequency-to-voltage converter), oscillator, error amplifier, and PWM generator are provided. A comparator is also provided for excess current detection and current limiting. The IC is implemented in National Semiconductor's BLOCCS process technology. Supply voltage range is 7-24 V and the supply current is 20 mA. The IC has an internal regulated voltage level of 5 V, and the input voltage levels are TTL-compatible (with pull-up for open-collector drives). The authors include typical performance data a waveforms.
Terminal nucleotides of the preintegrative linear form of HIV-1 DNA deduced from the sequence of circular DNA junctions. (1990)

The termini of integrated retroviral DNAs are characterized by highly conserved dinucleotide sequences: 5'TG...//...CA3'. For the avian and murine C-type retroviruses, the dinucleotide sequences reside two deoxynucleotides (usually AA and TT) from the LTR ends of unintegrated viral DNA (5' AATG...//...CATT3'). The number and identity of terminal deoxynucleotides in unintegrated HIV-1 linear DNA that extend beyond the conserved dinucleotides have not been determined. However, they had been presumed to consist of a single nucleotide (5'CTG...//...CAG3') on each end, based on inspection of the nucleotide sequence between the end of the supposed primer sites for retroviral DNA synthesis and the conserved proviral termini. We have utilized the polymerase chain reaction (PCR) to amplify segments representing the joined ends of linear DNA present in covalently closed circular HIV-1 DNA molecules isolated from infected T cells. These fragments were cloned and the nucleotide sequence of the LTR-LTR circle junction of several independent clones determined. Based upon the results, we predict that, like the avian and murine viruses, HIV-1 linear DNA contains two nucleotides beyond the conserved dinucleotides: 5'ACTG...//...CAGT3'. Models for the origin of these termini and other observed junction sequences are proposed.
Informe final proyecto cartografía fondos submarinos Islas del Rosario (Colombia) y apreciación de sus áreas, a partir de imágenes de satélite SPOT (1992)

Se hizo una calibración de las señales recibidas por el satélite SPOT en el área del Archipiélago del Rosario, utilizando un mapa de los fondos submarinos alrededor de la Isla Caribarú. Por medio de una clasificación de señal se ha hecho un mapa de los fondos submarinos de cero hasta cuatro metros de profundidad distinguiendo tres fondos: Arena con thalassia testudinum y Parches de corales. Después de una comparación de los datos de campo y con los resultados de la clasificación se efectuó una corrección para obtener una estimación de las superficies cubiertas para cada uno de los fondos en el Archipiélago.
Synthesis of 3-Mercaptothiophene-2-carboxylic Acid (1984)

Synthese a partir d'hydroxy-3 thiophenecarboxylate-2 de methyle via la transposition du diethylthiocarbamoyloxy-3 thiophenecarboxylate-2 en le derive diethylcarbamoylthio-3
<i>c</i>-axis inclined ZnO piezoelectric shear wave films (1983)

This letter reports on the growth and characterization of ZnO films having c axis oriented 40° to the substrate normal. These films are of significant interest for shear wave generation for bulk wave delay lines and resonators. The films were grown on Si wafers or membranes under low pressure and high growth rate conditions in a reactive dc planar magnetron sputtering system having an auxiliary anode structure. Shear wave resonators were fabricated and used for film evaluation. A ZnO/Si composite resonator exhibited a Q of approximately 4600 at 293-MHz fundamental resonance. The effective coupling coefficient of the film alone was found to be 17% (k2=0.029) using an edge-only supported ZnO plate resonator. The temperature coefficient of the ZnO resonator was found to be −36 ppm/°C and −20.5 ppm/°C for the composite structure.
Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold (2016)

A series of allosteric kidney-type glutaminase (GLS) inhibitors were designed and synthesized using 1,4-di(5-amino-1,3,4-thiadiazol-2-yl)butane as a core scaffold. A variety of modified phenylacetyl groups were incorporated into the 5-amino group of the two thiadiazole rings in an attempt to facilitate additional binding interactions with the allosteric binding site of GLS. Among the newly synthesized compounds, 4-hydroxy-N-[5-[4-[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]-1,3,4-thiadiazol-2-yl]-benzeneacetamide, 2m, potently inhibited GLS with an IC50 value of 70 nM, although it did not exhibit time-dependency as seen with CB-839. Antiproliferative effects of 2m on human breast cancer lines will be also presented in comparison with those observed with CB-839.
Three-Dimensional Structure and Composition of CA3→CA1 Axons in Rat Hippocampal Slices: Implications for Presynaptic Connectivity and Compartmentalization (1998)

Physiological studies of CA3-->CA1 synaptic transmission and plasticity have revealed both pre- and postsynaptic effects. Understanding the extent to which individual presynaptic axonal boutons could provide local compartments for control of synaptic efficacy and microconnectivity requires knowledge of their three-dimensional morphology and composition. In hippocampal slices, serial electron microscopy was used to examine a nearly homogeneous population of CA3-->CA1 axons in the middle of stratum radiatum of area CA1. The locations of postsynaptic densities (PSDs), vesicles, and mitochondria were determined along 75 axon segments (9.1 +/- 2.0 micrometer in length). Synapses, defined by the colocalization of PSDs and vesicles, occurred on average at 2.7 micrometer intervals along the axons. Most varicosities (68%) had one PSD, 19% had 2-4 PSDs, and 13% had none. Synaptic vesicles occurred in 90% of the varicosities. One-half (53%) of the varicosities lacked mitochondria, raising questions about their regulation of ATP and Ca2+, and 8% of varicosities contained only mitochondria. Eleven axons were reconstructed fully. The varicosities were oblong and varied greatly in both length (1.1 +/- 0.7 micrometer) and volume (0.13 +/- 0.14 micrometer 3), whereas the intervaricosity shafts were narrow, tubular, and similar in diameter (0.17 +/- 0.04 micrometer) but variable in length (1.4 +/- 1.2 micrometer). The narrow axonal shafts resemble dendritic spine necks and thus could promote biochemical compartmentalization of individual axonal varicosities. The findings raise the intriguing possibility of localized differences in metabolism and connectivity among different axons, varicosities, and synapses.
[The change of F2 and B2 in patients with complete denture]. (2004)

There is a definite regularity of speech articulation after restored with complete denture. CSL helps us to analyze speech articulation by visual accessing and provides basic theory of evaluation in clinical dental prosthetics.