gebhart/patrepeval huggingface dataset:
<i>gld/gld</i> mice are unable to express a functional ligand for Fas (1994)

Mice homozygous for either the lpr or gld genes develop phenotypically identical autoimmune disorders. The gene responsible for the pathology in lpr/lpr mice encodes the Fas antigen, a protein associated with the induction of programmed cell death. To determine if the defect associated with gld represents a mutation in the ligand for Fas, we have assessed the ability of lymphoid cells from homozygous gld/gld mice to lyse target cells in a Fas-dependent manner. Using an antagonistic antibody to Fas, we demonstrate that activated T cells from normal and lpr mice are capable of inducing Fas-mediated lysis of tumor target cells. In contrast, activated T cells from gld/gld mice fail to induce lysis of tumor targets, although cells from gld mice are able to lyse specific allogeneic targets following mixed lymphocyte culture. In addition, activated T cells from gld/gld homozygous animals are not capable of binding to a Fas.Fc fusion protein at high levels, whereas activated T cells from normal and lpr/lpr animals bind Fas.Fc efficiently. These data indicate that mice homozygous for gld are unable to express a functional ligand for Fas.
Aliphatic hydroxylation catalyzed by iron(III) porphyrins (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAliphatic hydroxylation catalyzed by iron(III) porphyrinsTeddy G. Traylor, Kenneth W. Hill, Wen Pang Fann, Shinji Tsuchiya, and Beth E. DunlapCite this: J. Am. Chem. Soc. 1992, 114, 4, 1308–1312Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/ja00030a028https://doi.org/10.1021/ja00030a028research-articleACS PublicationsRequest reuse permissionsArticle Views848Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Heart Rate Variability; An Index for Monitoring and Analyzing Human Autonomic Activities. (1999)

Heart rate variability (HRV), a non-invasive index of autonomic controls of the heart, has extensively been employed in various fields of study. The application range of this index persists to expand over the research horizon, and the need continues to demand technical complements for hitherto known deficiencies. Concurrent technical advances in recent years have yielded methodological techniques capable of performing quantitative analysis of HRV. However, as various approaches designed for HRV analysis exist, quantitative comparisons of the investigations have become difficult. Current physiological interpretations of the components of HRV are also inconsistent. Moreover, the issue of respiratory control has been much disputed when determining the HRV. In an attempt to clarify the current controversial state in HRV measurement, the present paper, based on the physiological background of HRV, pursued various procedures of HRV measurement and furnished global explanations for special features characterizing the various analytical approaches adopted thereof.
Preliminary Use of Ultrasonic Tomography Measurement to Map Tree Roots Growing in Earth Dikes (2015)

The aim is of this study to find a relevant criterion to detect and map tree roots in the surrounding soil. In each following ex- periments, we studied properties of propagation, espacially velocity and attenuation of amplitude, as parameters to discriminate the root from the soil. Our work has been initiated on laboratory experiment with an ultrasonic transmission device to highlight relative differences between samples of soil and roots. Measurements were repeated on different root samples (species, dimension, decomposition time) to cover the diversity encountered on dikes. Then an intermediate state device reproducing in-situ conditions in laboratory was performed at the soil surface in two plastic tank containers: one control of bare soil and another containing a root sample burried in homogeneous soil. We shown with laboratory experiments that information provided by the velocity term seems relevant to localize roots in the soil for healthy root samples. Same conclusion was derived from tanks study where significant variations of velocity were observed due to root presence.
Making Small Spheres (1951)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation W. L. Bond; Making Small Spheres. Rev Sci Instrum 1 May 1951; 22 (5): 344–345. https://doi.org/10.1063/1.1745930 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioReview of Scientific Instruments Search Advanced Search |Citation Search
Serum and liver cytosolic growth-hormone-binding proteins are antigenically identical with liver membrane ‘receptor’ types 1 and 2 (1986)

Studies with a panel of monoclonal antibodies (MAbs) reactive towards the presumptive rabbit liver growth-hormone (GH) receptor show that the rabbit serum GH-binding proteins share seven antigenic determinants (three at the hormone-binding site and four located elsewhere) with the liver cytosolic GH-binding proteins and the putative GH 'receptors' associated with the hepatocyte membrane. The rabbit serum binding proteins have an affinity for GH similar to the membrane GH receptors [for human GH, Ka = 2.45 (+/- 0.15) X 10(9) M-1 (mean +/- S.E.M., n = 8)] and high capacity relative to membrane 'GH receptors'. Analogues of the postulated membrane 'receptor' subtypes 1 and 2 exist in the serum, but not subtype 3, which is also absent from liver cytosol. The serum and cytosolic binding proteins have identical cation-dependence properties; hGH binding is Ca2+-dependent, whereas oGH binding is Ca2+-independent. Affinity labelling of hGH-affinity-purified serum binding proteins with 125I-hGH demonstrated a major GH-binding subunit, of Mr 55,000, identical with the major component purified from membranes. In view of their high affinity and capacity, the serum binding proteins could control availability of GH to membrane receptors. It is suggested that the cytosolic binding proteins may be newly synthesized serum binding proteins. The existence of a close relationship between subsets of membrane-associated GH-binding sites, the serum GH-binding proteins and cytosolic GH-binding proteins dictates a reappraisal of earlier ligand-binding studies, which did not distinguish between binding-site subsets in the liver.
Control middleware for open robot controllers (2007)

To organize the robot controllers in an open manner and manage heterogeneous and concurrent accesses to hardware devices is a tough problem. This paper proposes the control middleware architecture to tackle this problem. In this architecture, the control middleware encapsulates all hardware operations and interacts with logical controllers in a client-server manner. All devices are mapped into data channels, and the middleware system acts as a data server providing read and write access function to client controllers. A wrapper method is adopted to organize heterogeneous hardware devices into few types of abstract devices, so that users can extend the system to support new types of physical devices easily. A communication interface is set up to enable command exchange between the middleware and the logical controllers either locally or remotely. The middleware defines a standard protocol that the logical controllers can perform manipulations to desired device regardless of their driving mechanism. On one hand, the control middleware can manage various types of peripheral devices, including the functions of extension, substitution, maintenance, scheduling and channel mapping. On the other hand, the control middleware can also provide uniform access software channels for high-level logical control layer, to enable access control of low-level device drivers.
Linear and Branched Chitosan Oligomers as Delivery Systems for pDNA and siRNA In Vitro and In Vivo (2006)

In this thesis, chitosan, a biocompatible polysaccharide that has been approved as a food additive was selected as a platform for the development of safe, efficient non-viral gene delivery systems to mammalian cells. Previously, chitosan-based gene formulations had been generally associated with high molecular weight chitosans, which were poorly characterised in terms of molecular weight distribution and degree of acetylation. Therefore, in order to improve the properties of chitosan-based gene formulations, the research associated with this thesis focused on establishing the structure-property relationships of well-defined, low molecular weight chitosans (chitosan oligomers) as delivery systems for nucleic acids (pDNA and siRNA) in vitro and after lung administration in vivo. pDNA dissociated more easily from chitosan oligomers than from conventional high molecular weight chitosans, resulting in a faster onset and higher levels of in vivo gene expression, comparable to those mediated by polyethyleneimine (PEI), one of the most efficient non-viral delivery systems. Coupling of a trisaccharide branch to the chitosan oligomers so as to target extracellular lectins resulted in a significant improvement in transfection efficiency because of enhanced cellular uptake and colloidal stability. In contrast to pDNA, longer linear chitosan oligomers were required to form physically-stable nanoparticles with siRNA that mediated efficient, sustained gene silencing in vitro. Finally, the use of an optimised catheter device for the nebulisation of small volumes of pDNA formulations resulted in improved dose precision and lung distribution in vivo compared with conventional intratracheal instillation. In conclusion, chitosan oligomers are interesting and viable alternatives to other non-viral gene delivery systems.
Energy Adaptive Cluster-Head Selection for Wireless Sensor Networks (2005)

A wireless network consisting of a large number of small sensors with limited battery power can be an effective tool for gathering data in a variety of environments. Clustering sensors into groups, so that sensors communicate information only to cluster-heads and then the cluster-heads communicate the aggregated information to the base station, may save energy. In this paper, we propose an optimal energyadaptive clustering algorithm which is motivated from the LEACH protocol presented in [4]. We optimize LEACH’s random cluster-head selection algorithm to ensure the balanced energy depletion over the whole network thus prolongs the network lifetime. Simulation results show that our algorithm outperforms LEACH by about 20% to 35% when 1%, 50%, 100% of nodes die for different network sizes and topologies.
Microbiological Studies of the Intestinal Microflora of the Koala, Phascolarctos-Cinereus .2. Pap, a Special Maternal Feces Consumed by Juvenile Koalas (1993)

Quantitative and qualitative studies on the microflora in the faeces of 10 female koalas, Phascolarctos cinereus, were conducted with specific reference to 'pap', a special maternal faeces consumed by the juvenile at about the time of first emergence from the pouch. This specific coprophagy, called 'pap feeding', occurred multiple times in all of the females examined. Pap was higher in water content (81.8%) and pH (7.0) than normal faeces produced by the females before and after pap feeding (54.6-56.4% and 5.5, respectively), suggesting that it is derived directly from the contents of the caecum. Pap had higher (23-41-fold) viable counts of tannin-protein-complex-degrading enterobacteria (T-PCDE) than the normal faeces; in four of the females examined, viable T-PCDE were found in pap but never in the normal faeces. The evidence indicates that pap feeding is an essential physiological activity for the juvenile koala to prepare it for an imminent dietary transition from maternal milk to tannin-rich eucalypt leaves.
Learning to Rank Using Classification and Gradient Boosting (2008)

We cast the ranking problem as (1) multiple classi cation (2) multiple ordinal classi cation, which lead to computationally tractable learning algorithms for relevance ranking in Web search. We consider the DCG criterion (discounted cumulative gain), a standard quality measure in information retrieval. Our approach is motivated by the fact that perfect classi cations naturally result in perfect DCG scores and the DCG errors are bounded by classi cation errors. We propose using the Expected Relevance to convert the class probabilities into ranking scores. The class probabilities are learned using a gradient boosting tree algorithm. Evaluations on large-scale datasets show that our approach can improve LambdaRank [5] and the regressions-based ranker [6], in terms of the (normalized) DCG scores.
Fast Circular Tomography Device for Cardiac Imaging: Image Deflection Mechanism and Evaluation (1987)

A circular tomography system for cardiac imaging is described and measurements of the detector system are presented. Fast tomographic motion is obtained with a custom-made rotating focal spot X-ray tube combined with servo-operated scanning mirrors that deflect the optical image between a large field of view image intensifier and television camera. The motion of the deflection mirrors is locked in frequency and phase to the position of the focal spot with precision analog electronics. Initial measurements on the system components indicate that circular tomograms of the beating heart can be obtained in 1/60 s at rates as high as 30/s. Image degradation due to focal spot tracking error is minimal; however, the optical temporal lag of a P-20 type image intensifier output phosphor results in a factor of three contrast loss for millimeter-sized objects. A linear system analysis in conjunction with the measured temporal step response of the phosphor is in good agreement with the magnitude of this contrast loss.
Aberrant Appearance of Lung Surfactant Protein A in Sera of Patients with Idiopathic Pulmonary Fibrosis and Its Clinical Significance (1995)

Pulmonary surfactant protein A (SP-A) is known to be a major phospholipid-associated glycoprotein in pulmonary surfactant, which is specific to the lung. In this study, the SP-A concentrations in sera of patients with various lung diseases were determined using an enzyme-linked immunosorbent assay. Patients with idiopathic pulmonary fibrosis (IPF) and pulmonary alveolar proteinosis (PAP) exhibited prominently high concentrations of serum SP-A compared to those of other lung diseases and healthy volunteers, although there were significant increases in serum SP-A concentrations in patients with pulmonary tuberculosis, chronic pulmonary emphysema, diffuse panbronchiolitis and bacterial pneumonia compared to those of healthy volunteers. Successive measurement in 2 patients with IPF showed that serum SP-A levels reflect the disease activity of IPF. In patients with IPF, serum SP-A concentrations were significantly correlated with those of serum lactate dehydrogenase, whereas there were no significant correlations of serum SP-A concentrations with erythrocyte sedimentation rate, arterial oxygen saturation, vital capacity and carbon monoxide diffusing capacity. Determination of serum SP-A will contribute to diagnosing IPF and PAP, and may reflect the disease activity of IPF.
Research on the Procurement Platform for MRO Materials Based on E-Commerce (2011)

The enterprises are purchasing more and more emphasis on the control of purchasing cost since the competition grew. But many companies paid more attention to the control of purchasing cost since the competition grew. But many companies paid more attention to purchasing cost control only on the production of materials. So that, even though the cost of procurement of materials production declined, but because of non-productive procurement costs of materials not decline. While non-productive cost of procurement of materials procurement costs account for very large enterprises, and possession of a large number of procurement time. This article proposed E-commerce-based procurement of MRO industrial supplies platform that integrates MRO materials suppliers, MRO customers, logistics providers and other related businesses with the MRO materials based on the domestic MRO procurement status. Through the integration, the supply chain of MRO can be achieved lowest cost, highest efficiency, to improve the competitiveness of the supply chain purposes.
Concurrent HDAC and mTORC1 Inhibition Attenuate Androgen Receptor and Hypoxia Signaling Associated with Alterations in MicroRNA Expression (2011)

Specific inhibitors towards Histone Deacetylases (HDACs) and Mammalian Target of Rapamycin Complex 1 (mTORC1) have been developed and demonstrate potential as treatments for patients with advanced and/or metastatic and castrate resistant prostate cancer (PCa). Further, deregulation of HDAC expression and mTORC1 activity are documented in PCa and provide rational targets to create new therapeutic strategies to treat PCa. Here we report the use of the c-Myc adenocarcinoma cell line from the c-Myc transgenic mouse with prostate cancer to evaluate the in vitro and in vivo anti-tumor activity of the combination of the HDAC inhibitor panobinostat with the mTORC1 inhibitor everolimus. Panobinostat/everolimus combination treatment resulted in significantly greater antitumor activity in mice bearing androgen sensitive Myc-CaP and castrate resistant Myc-CaP tumors compared to single treatments. We identified that panobinostat/everolimus combination resulted in enhanced anti-tumor activity mediated by decreased tumor growth concurrent with augmentation of p21 and p27 expression and the attenuation of angiogenesis and tumor proliferation via androgen receptor, c-Myc and HIF-1α signaling. Also, we observed altered expression of microRNAs associated with these three transcription factors. Overall, our results demonstrate that low dose concurrent panobinostat/everolimus combination therapy is well tolerated and results in greater anti-tumor activity compared to single treatments in tumor bearing immuno-competent mice. Finally, our results suggest that response of selected miRs could be utilized to monitor panobinostat/everolimus in vivo activity.
Super-RENS Disk for Blue Laser System Retrieving Signals from Polycarbonate Substrate Side (2005)

Super-resolution near-field structure (super-RENS) technology was applied to the high definition digital versatile disk (HD DVD) based system that retrieves signals from the polycarbonate substrate side using a blue laser. We used an optics with a laser wavelength (λ) of 405 nm and a numerical aperture (NA) of 0.65, and have obtained high carrier-to-noise ratios (CNRs) of 45 dB at a 100 nm mark length and 40 dB at 60 nm, which are smaller than the resolution limit (λ/4NA=156 nm). The results demonstrate that the technology can also be used in the HD DVD-based system. We discussed how well the CNR is obtained below the resolution limit when this technology is used in the DVD-, Blu-ray Disc- and HD DVD-based systems. Comparison of the best results to date strongly suggests that the difference between these systems simply comes from their λ and NA.
Converting‐enzyme inhibition buffers the counter‐regulatory response to acute administration of nicardipine. (1987)

1. To investigate the interaction of angiotensin-converting-enzyme (ACE) inhibitor and calcium antagonist, we conducted a double-blind randomized, placebo-controlled crossover study of a new ACE inhibitor (CGS 14824 A, 20 mg) during intravenous administration (i.v.) of nicardipine in eight normotensive healthy subjects. Nicardipine was infused to give cumulative doses of 1.25, 3.75, and 8.75 mg after 10, 20 and 30 min. 2. ACE inhibition was demonstrated 24 h after the first CGS 14 824 A intake (61%). Three hours after the second dose this inhibition was more marked (98%). 3. I.v. nicardipine administration induced a significant and similar fall in systolic or diastolic blood pressure with and without ACE activity (-3/-6 vs -2/-8%), while tachycardia was significantly decreased by CGS 14 824 A (+14 vs +30%, P less than 0.02). The increase of plasma noradrenaline was also significantly blunted (+1.8 +/- 0.3 vs +3.1 +/- 0.7 pmol ml-1, P less than 0.05). 4. Active and total plasma renin increased at the end of nicardipine infusion in the presence or absence of ACE inhibition. Inactive renin did not increase after nicardipine infusion under placebo. It was higher 3 h after the second intake of CGS 14 824 A and then increased after nicardipine infusion. 5. The rise in plasma aldosterone during i.v. calcium antagonist infusion was diminished after ACE inhibition (126 +/- 39 vs 277 +/- 120 pmol l-1, P less than 0.02). 6. In conclusion, converting-enzyme inhibition buffers the rise in heart rate, plasma noradrenaline and plasma aldosterone induced by acute calcium blockade.
A review of automated image understanding within 3D baggage computed tomography security screening (2015)

Baggage inspection is the principal safeguard against the transportation of prohibited and potentially dangerous materials at airport security checkpoints. Although traditionally performed by 2D X-ray based scanning, increasingly stringent security regulations have led to a growing demand for more advanced imaging technologies. The role of X-ray Computed Tomography is thus rapidly expanding beyond the traditional materials-based detection of explosives. The development of computer vision and image processing techniques for the automated understanding of 3D baggage-CT imagery is however, complicated by poor image resolutions, image clutter and high levels of noise and artefacts. We discuss the recent and most pertinent advancements and identify topics for future research within the challenging domain of automated image understanding for baggage security screening CT.