gebhart/patrepeval huggingface dataset:
RF circuit performance degradation due to soft breakdown and hot-carrier effect in deep-submicrometer CMOS technology (2001)

A systematic study of RF circuit performance degradation subject to oxide soft breakdown (SBD), and hot-carrier (HC) stress is presented in this paper. DC and RF characteristics before and after stress are extracted from the experimental data. The effects of SBD and HC stress on s-parameters, cutoff frequency, third-order interception point, and noise parameters are examined. The performance drifts of gain, noise figure, linearity, and input matching of the RF low-noise amplifier are demonstrated by SpectreRF simulation results based on measured device data.
GaInAs monolithic photoreceiver integrating p-i-n/JFET with diffused junctions and a resistor (1988)

An integrated p-i-n/JFET/resistor has been developed using a GaInAs epitaxial structure grown on a planar substrate A four-layered structure allows separate optimization of both active devices. Owing to the good performances and high reliability of individual components, the sensitivity of these monolithic photoreceivers is evaluated as -29 dBm at 560 Mb/s (10/sup -9/ bit error rate). Remarkable stability over time is exhibited.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hepatic Glutamine Transport and Metabolism (1998)

Although the liver was long known to play a major role in the uptake, synthesis, and disposition of glutamine, metabolite balance studies across the whole liver yielded apparently contradictory findings suggesting that little or no net turnover of glutamine occurred in this organ. Efforts to understand the unique regulatory properties of hepatic glutaminase culminated in the conceptual reformulation of the pathway for glutamine synthesis and turnover, especially as regards the role of sub-acinar distribution of glutamine synthetase and glutaminase. This chapter describes these processes as well as the role of glutamine in hepatocellular hydration, a process that is the consequence of cumulative, osmotically active uptake of glutamine into cells. This topic is also examined in terms of the effects of cell swelling on the selective stimulation or inhibition of other far-ranging cellular processes. The pathophysiology of the intercellular glutamine cycle in cirrhosis is also considered.
Liquid-crystal color display by DAP-TN double-layered structure (1974)

A liquid-crystal display device is reported combining a polarizer, a deformation of aligned phases (DAP) cell, a twisted nematic (TN) cell, and an analyzer in series arrangement. The color of the transmitted light can be modulated by the application of voltage to the DAP cell. The transmission properties of the device can be switched from the DAP mode for crossed polarizers to that for parallel polarizers by the application of voltage to the TN cell. This improves control of the transmitted color.
Molecular genetic basis of pod corn ( <i>Tunicate</i> maize) (2012)

Pod corn is a classic morphological mutant of maize in which the mature kernels of the cob are covered by glumes, in contrast to generally grown maize varieties in which kernels are naked. Pod corn, known since pre-Columbian times, is the result of a dominant gain-of-function mutation at the Tunicate (Tu) locus. Some classic articles of 20th century maize genetics reported that the mutant Tu locus is complex, but molecular details remained elusive. Here, we show that pod corn is caused by a cis-regulatory mutation and duplication of the ZMM19 MADS-box gene. Although the WT locus contains a single-copy gene that is expressed in vegetative organs only, mutation and duplication of ZMM19 in Tu lead to ectopic expression of the gene in the inflorescences, thus conferring vegetative traits to reproductive organs.
Gas Well Test Analysis: Use of Normalized Pseudovariables (1987)

Summary Pressure data from gas wells are normally analyzed by use of pseudopressure, which is a transformation of measured pressure. When tests are associated with large pressure changes accompanied by a severe wellbore storage effect, such as in tight reservoirs, use is made of pseudopressure and pseudotime transforms. The purpose of the pseudovariables is to linearize "effectively" the governing diffusivity equation so that proper test interpretation can be made. In this study, normalized pseudovariables or transforms are introduced. Use of these new pseudovariables produces results identical to those obtained with the conventional pseudovariables. However, the proposed pseudovariables offer some distinct practical advantages. For example, units of pressure and time are retained, thus giving a physical "feel" for the pseudovariable definitions. Other features include use of liquid equations for solving the gas flow problems—i.e., constants of the working equations remain unchanged. This study also proposes two methods for estimating the rate-dependent skin, together with permeability, mechanical skin, and well deliverability. The first method involves logarithmic convolution of pressure with flow rate, both measured downhole, by use of a radial model. A trial-and-error approach is used to obtain the rate-dependent skin on a convolution plot. The second method requires a transient flow-after-flow test of short duration; a standard graphic technique allows the estimation of the desired reservoir parameters. Once the reservoir parameters are estimated with either method, the absolute open-flow potential (AOFP) of a well can be established by assuming a reservoir radius because the AOFP is relatively insensitive to this assumption.
Optimal filtering for uncertain linear stochastic systems (2009)

This paper presents the optimal joint filtering and parameter identification problem for uncertain linear stochastic systems with unknown parameters in both state and observation equations, where the unknown parameters are considered Wiener processes. The original problem is reduced to the filtering problem for an extended state vector that incorporates parameters as additional states. The resulting filtering system is polynomial in state and linear in observations. The obtained optimal filter for the extended state vector also serves as the optimal identifier for the unknown parameters. Performance of the designed optimal state filter and parameter identifier is verified for both, positive and negative, parameter values.
Diagnostic tests for Helicobacter pylori: a prospective evaluation of their accuracy, without selecting a single test as the gold standard. (1996)

All antral biopsy-based tests, as well as the 13C-urea breath test, are accurate for the diagnosis of H. pylori infection. Sampling error is a problem of minor importance. The lower specificity of serological tests may be largely explained by previous treatment of H. pylori.
A physical and genetic map of <i>Cannabis sativa</i> identifies extensive rearrangements at the <i>THC/CBD acid synthase</i> loci (2018)

<i>Cannabis sativa</i> is widely cultivated for medicinal, food, industrial, and recreational use, but much remains unknown regarding its genetics, including the molecular determinants of cannabinoid content. Here, we describe a combined physical and genetic map derived from a cross between the drug-type strain Purple Kush and the hemp variety "Finola." The map reveals that cannabinoid biosynthesis genes are generally unlinked but that aromatic prenyltransferase (<i>AP</i>), which produces the substrate for THCA and CBDA synthases (THCAS and CBDAS), is tightly linked to a known marker for total cannabinoid content. We further identify the gene encoding CBCA synthase (<i>CBCAS</i>) and characterize its catalytic activity, providing insight into how cannabinoid diversity arises in cannabis. <i>THCAS</i> and <i>CBDAS</i> (which determine the drug vs. hemp chemotype) are contained within large (>250 kb) retrotransposon-rich regions that are highly nonhomologous between drug- and hemp-type alleles and are furthermore embedded within ∼40 Mb of minimally recombining repetitive DNA. The chromosome structures are similar to those in grains such as wheat, with recombination focused in gene-rich, repeat-depleted regions near chromosome ends. The physical and genetic map should facilitate further dissection of genetic and molecular mechanisms in this commercially and medically important plant.
Implementation of a directional beacon-based position location algorithm in a signal processing framework (2010)

We present the implementation of a directional beacon-based positioning algorithm using radio frequency signals. This algorithm allows each mobile node to compute its position with respect to a set of reference nodes which are equipped with a rotating directional antenna. The use of directional beacon-based algorithm for position location eliminates the need for strict synchronization between the reference nodes and the mobile node. In contrast to positioning algorithms that rely on signal propagation time and bandwidth, the proposed algorithm depends on the beam-width and rotational speed of the directional antenna. We will show that these parameters can be optimized with a low cost solution that provides good positioning accuracy. The system implementation is based on the GNU radio software platform and the universal software radio peripheral as the hardware component. We present an enhanced maximum likelihood method for estimating the received signal amplitude profile. To deal with obstructed line-of-sight scenarios, we do not rely purely on the received signal strength and instead formulate a least squares problem to estimate the line-of-sight component in a multipath environment. These advanced signal processing techniques yield a more accurate estimate of the bearing of the mobile node with respect to each of the reference nodes. We also show that the proposed positioning algorithm is tolerant to errors in timing and synchronization. We demonstrate the ability to obtain mobile node position estimates with sub-meter accuracy by transmitting a narrowband signal of 1 kHz bandwidth in the 2.4-2.5 GHz band. The experimental results show a mean position error of 0.759 m, in a field measuring 55m by 43m, using eight 90° rotations of the antenna.
In vivo studies on protease and elastase from Pseudomonas aeruginosa. (1975)

Protease and elastase from Pseudomonas aeruginosa were inoculated in female mice by intravenous, intraperitoneal, intrapleural and intranasal route, and the lethality and damage of various organs were examined. The protease and elastase exhibited respectively the following minimum lethal dose (MLD) values in 24 hr; 300 and 375 mug inoculated intravenously; 200 and 125-250 mug intraperitoneally; and 100 and 62.5 mug intrapleurally. The instillation of a defined dose of the enzyme by the intranasal route was difficult to control, therefore the MLD could not be defined exactly. The protease and elastase were capable of eliciting hemorrhage at various organs of mice according to the route of inoculation. Of protease, intravenous injections elicited petechial hemorrhage at the lungs and parietal bone-area, and severe one in the medullary area of kidney. The intraperitoneal injection resulted in petechial hemorrhage of the lungs, diaphragm, peritoneum and gastrointestinal serosa. Intrapleural injections and intranasal instillation resulted in confluent pulmonary hemorrhage. Of elastase, intravenous injections elicited confluent pulmonary hemorrhage, hemorrhage in the medullary area of kidney and cerebral ventricles, and petechial hemorrhage at the stomach-walls. The intraperitoneal injections resulted in petechial hemorrhage at the lungs, diaphragm, peritoneum and gastointestinal serosa. Intrapleural injections resulted in confluent pulmonary hemorrhage, and petechiae at the diaphragm and pleura. Intranasal instillation resulted in confluent pulmonary hemorrhage.
Unequal packet loss resilience for fine-granular-scalability video (2001)

Several embedded video coding schemes have been recently developed for multimedia streaming over IP. In particular, fine-granular-scalability (FGS) video coding has been recently adopted by the MPEG-4 standard as the core video-compression method for streaming applications. From its inception, the FGS scalability structure was designed to be packet-loss resilient especially under unequal packet-loss protection (UPP). However, since the introduction of FGS, there has not been a comprehensive study evaluating its packet-loss resilience under unrecoverable packet losses that are common in Internet streaming applications. In this paper, we evaluate two important aspects of FGS packet-loss resilience. First, we study the impact of applying UPP between the base- and enhancement-layers on FGS-based streams, and we compare equal packet-loss protection (EPP) with UPP scenarios. Second, we introduce the notion of fine-grained loss protection (FGLP), which is suitable for the FGS enhancement-layer, and we develop an analytical framework for evaluating FGLP bounds. Based on these bounds, we show the impact of applying fine-grained protection to the FGS enhancement-layer for different types of video sequences and over a wide range of bit-rates and packet-loss ratios. As illustrated by our extensive simulation results, applying 1) UPP between the base- and enhancement-layers and 2) FGLP for the FGS enhancement-layer can provide significant resilience under moderate-to-high packet-loss ratios (e.g., 5-10%). Furthermore, the merits of this new packet-loss protection technique go beyond the FGS coding scheme, because FGLP can be successfully applied to improve the resilience to packet-losses of other embedded video coding techniques.
Transconductor (2010)

The proposed low-voltage, highly linear, and tunable triode transconductor achieves the wide linear input range up to 2.4V. The total harmonic distortion is -60dB with a 0.7Vpp input voltage. The design uses TSMC 0.18m CMOS technology and supply voltage is 1.8V. Moreover, it exhibits a large Gm tuning range from 3.4S to 542S and also keeps a wide linear input range. Finally, the performance comparison with other linear techniques shows that the proposed technique achieves better linearity, wider tuning range, and wider linear input range.
Next-Generation Treatments for Mental Disorders (2012)

There has been a steady retreat by the private sector away from developing medications for mental disorders. This retreat comes just as research is identifying new molecular targets, new clinical targets, and new uses of current treatments that may serve as the basis for the next generation of treatments for mental disorders.
All-cis catalytic hydrogenation of polynuclear aromatic hydrocarbons by Group 5 metal aryl oxide compounds (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAll-cis catalytic hydrogenation of polynuclear aromatic hydrocarbons by Group 5 metal aryl oxide compoundsJoyce S. Yu, Bernardeta C. Ankianiec, Ian P. Rothwell, and Mindy T. NguyenCite this: J. Am. Chem. Soc. 1992, 114, 5, 1927–1929Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/ja00031a084https://doi.org/10.1021/ja00031a084research-articleACS PublicationsRequest reuse permissionsArticle Views531Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Characterization of the isolation membranes and the limiting membranes of autophagosomes in rat hepatocytes by lectin cytochemistry. (1990)

The isolation membranes and the limiting membranes of autophagosomes in rat hepatocytes were characterized by lectin cytochemistry using concanavalin A (ConA), Ricinus communis agglutinin 120 (RCA-120), and wheat germ agglutinin (WGA). We found that RCA-120, ConA, and WGA bind to these membranes. The distribution of the lectins on the isolation membranes was heterogeneous, mainly found on the rims, which we referred to as the peripheral dilated portion. When the rims fused and thus formed autophagosomes the apparent sites of fusion were strongly labeled by the lectins. After autophagosomes were transformed to autolysosomes by fusion with lysosomes, the limiting membranes became more densely and homogeneously labeled with the lectins. We previously reported that cytochrome P-450 does not exist on the limiting membranes of the autophagosomes. Taken together, these results suggest that the isolation membranes may originate not from endoplasmic reticulum membranes but from some post-Golgi membranes that contain complex type N and/or O-linked oligosaccharide chains.
Passive and Active Polymer Coatings for Intracoronary Stents: Novel Devices to Promote Arterial Healing (2009)

Coronary stent implantation is the second great advance in the treatment of obstructive coronary artery disease since the introduction of balloon catheter angioplasty. However, in-stent restenosis (ISR) caused by neointimal hyperplasia has been a major limitation of stents, occurring in up to 30% of cases. Advances in coronary stent technology both in terms of stent design and function and especially drug-eluting stents (DES) have significantly improved the safety and efficacy of percutaneous coronary intervention (PCI) with stenting, including marked reduction in ISR. This has led to use of DES for increasingly challenging clinical and lesional subsets, with potential for increased risk of stent-associated complications, especially late stent thrombosis (LST). Because restenosis and stent thrombosis are caused by multiple and often interrelated factors, ideal agents for stent coatings should inhibit thrombus formation, inflammatory reaction, and cellular proliferation, while supporting reendothelialization. To avoid undesirable effects of currently applied (durable) polymers, biocompatible, and bioabsorbable polymers as well as DES delivery systems that minimize polymer burden have been produced and tested. Bioabsorbable stents, both polymeric and metallic, have been developed to decrease potential late complications after stent implantation. Novel strategies to address some of these challenges are in various stages of research and development. In this article we outline developments in the field of passive and active stent coatings and evaluate the ongoing role of such coatings in the contemporary era of DES.
Clinical implications of trials investigating drug‐drug interactions between cannabidiol and enzyme inducers or inhibitors or common antiseizure drugs (2020)

Highly purified cannabidiol (CBD) has demonstrated efficacy with an acceptable safety profile in patients with Lennox-Gastaut syndrome or Dravet syndrome in randomized, double-blind, add-on, controlled phase 3 trials. It is important to consider the possibility of drug-drug interactions (DDIs). Here, we review six trials of CBD (Epidiolex/Epidyolex; 100 mg/mL oral solution) in healthy volunteers or patients with epilepsy, which investigated potential interactions between CBD and enzymes involved in drug metabolism of common antiseizure drugs (ASDs). CBD did not affect CYP3A4 activity. Induction of CYP3A4 and CYP2C19 led to small reductions in exposure to CBD and its major metabolites. Inhibition of CYP3A4 activity did not affect CBD exposure and caused small increases in exposure to CBD metabolites. Inhibition of CYP2C19 activity led to a small increase in exposure to CBD and small decreases in exposure to CBD metabolites. One potentially clinically important DDI was identified: combination of CBD and clobazam (CLB) did not affect CBD or CLB exposure, but increased exposure to major metabolites of both compounds. Reduction of CLB dose may be considered if adverse reactions known to occur with CLB are experienced when it is coadministered with CBD. There was a small increase of exposure to stiripentol (STP) when coadministered with CBD. STP had no effect on CBD exposure but led to minor decreases in exposure to CBD metabolites. Combination of CBD and valproate (VPA) did not cause clinically important changes in the pharmacokinetics of either drug, or 2-propyl-4-pentenoic acid. Concomitant VPA caused small increases in exposure to CBD metabolites. Dose adjustments are not likely to be necessary when CBD is combined with STP or VPA. The safety results from these trials were consistent with the known safety profile of CBD. These trials indicate an overall low potential for DDIs between CBD and other ASDs, except for CLB.
Mitochondrial DNA 4977 BP deletion mutations in lung carcinoma (2006)

Mitochondrial DNA 4,977 bp deletion, which is not specific to lung cancer, may reflect the environmental and aging process influences operative during tumor progression.
Exploratory sequential data analysis for multi-agent occupancy simulation results (2015)

In this paper we apply the principles of Exploratory Sequential Data Analysis (ESDA) to simulation results analysis. We replicate a resource consumption simulation of occupants in a building and analyze the results using an open-source ESDA tool called UberTagger previously only used in the human-computer interaction (HCI) domain. We demonstrate the usefulness of ESDA by applying it to a hotel occupant simulation involving water and energy consumption. We have found that using a system which implements ESDA principles helps practitioners better understand their simulation models, form hypotheses about simulated behavior, more effectively debug simulation code, and more easily communicate their findings to others.
Performance evaluation of a high-speed data transmission system with modulo-type preequalization (2002)

Systems designed for high-speed data transmission in fixed wireless communications must combat multipath fading as well as intersymbol interference (ISI). The effects of these impairments on transceiver design are evaluated. The system architecture of a Reed Solomon (RS) encoder concatenated with inner trellis code and adaptive Tomlinson-Harashima (1971) precoder in time-division-duplex (TDD) radio system is described. The performance of such a system is evaluated and analyzed.