gebhart/patrepeval huggingface dataset:
2'-Deoxythioguanosine and Related Nucleosides<sup>1</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2'-Deoxythioguanosine and Related Nucleosides1Robert H. Iwamoto, Edward M. Acton, and Leon GoodmanCite this: J. Med. Chem. 1963, 6, 6, 684–688Publication Date (Print):November 1, 1963Publication History Published online1 May 2002Published inissue 1 November 1963https://pubs.acs.org/doi/10.1021/jm00342a012https://doi.org/10.1021/jm00342a012research-articleACS PublicationsRequest reuse permissionsArticle Views196Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
All-fiber acousto-optic frequency shifter (1986)

An all-fiber-optic frequency shifter is demonstrated that uses mode coupling between the LP(01) and LP(11) modes by a traveling acoustic flexural wave guided along the optical fiber. The input and output leads of this frequency shifter are single-mode fibers. Unity mode-conversion efficiency for cw operation is achieved at 8-MHz frequency shift with about 0.25 W of electrical input power. Carrier and image sideband suppression of 15 and 35 dB, respectively, are demonstrated.
Studies of Drug Delivery Systems for Granulocyte Colony-Stimulating Factor. Part III. Pharmacodynamics and Pharmacokinetics of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Administration of a Rectal Dosage Vehicle. (1996)

The pharmacodynamic activities (leukopoietic effect) and pharmacokinetics of recombinant human granulocyte colony-stimulating factor (rhG-CSF) administered rectally in various doses as hollow-type suppositories were investigated in rabbits. Three kinds of rhG-CSF hollow-type suppositories were employed: suppository I containing rhG-CSF (100-1000 micrograms/kg) in 10 mM acetate buffer solution (ABS) at pH 4.0, suppository II containing rhG-CSF in ABS with alpha-cyclodextrin (alpha-CyD) as an absorption-enhancing agent, and suppository III containing lyophilized rhG-CSF powder. We found that the total count of leukocytes in peripheral blood (total blood leukocyte count) and serum granulocyte colony-stimulating factor (G-CSF) concentration showed a dose-dependent increase. Consequently, the area under the increased total blood leukocyte count-time curve (AUI), an index of pharmacodynamic activity, and the area under the serum G-CSF concentration-time curve (AUC), a pharmacokinetic parameter, increased with an increase in the rhG-CSF dose administered rectally. Good correlation was found between AUL and AUC; thus, it is concluded that an increase in AUC leads to an increase in the effect of rhG-CSF in inducing leukopoiesis in rabbits following rectal administration. We report for the first time the rectal absorption of rhG-CSF using a new rectal dosage vehicle (rhG-CSF hollow-type suppository) and its leukopoietic effect. The rhG-CSF hollow-type suppository is found to be a promising drug delivery system.
The 21st century environment and air quality influences on asthma (1999)

"Criteria" air pollutants are federally regulated pollutants that occur widely outdoors and have diverse sources, most often related to combustion. They include ozone (O3), particulate matter, sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and lead. All except lead may interfere with oxygen delivery, and so may be of special concern to asthmatics. In controlled experiments, SO2 causes acute asthma symptoms and bronchoconstriction, preventable by beta-agonist medications. Ozone causes acute irritant symptoms, restrictive lung dysfunction, increased bronchial reactivity, and lower-airway inflammation in healthy people and asthmatics. Exposures to O3, and possibly to other pollutants, appear to exacerbate bronchoconstrictive or inflammatory responses to inhaled aeroallergens (bioaerosols); this may represent an important health risk to asthmatics. Exposure levels known to evoke acute responses to O3 or SO2 are uncommon in community air pollution; however, some asthmatics might be susceptible to lesser, more common exposures. Evidence concerning NO2 is equivocal, but it may have O3-like effects in some asthmatics. Epidemiology has often associated particulate pollution with asthma exacerbations and other cardiorespiratory illnesses, even in cities with relatively mild air pollution. Current laboratory research cannot fully explain this association. Advances in emission controls should further reduce ambient pollution levels, but probably will not reduce asthma morbidity. Better asthma management, with improved anti-inflammatory medications, more careful monitoring by patients and health care providers, and reasonable efforts to reduce pollutant and aeroallergen exposures, offers the best hope to reduce asthma morbidity in the new century.
An AlN-on-Si resonant IR sensor array with a large temperature coefficient of frequency (2016)

This work reports on novel AlN-on-Si flexural-mode resonators with a high fill-factor used as Infrared (IR) sensors. The devices are designed to achieve large temperature coefficient of frequency (TCF) utilizing the thermal expansion coefficient mismatch of different layers in the resonant stack. A 2×2 array of 4.6 MHz resonators with a quality factor (Q) of ~1140 is designed and fabricated using the InvenSense CMOS-MEMS process. Measured TCF values are as high as -137 ppm/K, noticeably higher than the expected TCF derived from temperature coefficient of elasticity (TCE) of AlN and silicon. The reported TCF value in this work is more than four times larger than the previously reported values for AlN-or silicon-based resonators and resonant detectors.
Introducing hearing aids to parents of infants (1999)

Julie Hauser, MS, CCC-A, is Coordinator of the Amplification Program in the Department of Audiology and Communication Disorders at Children's Hospital of Pittsburgh. Correspondence to the author at the hospital, 3705 Fifth Avenue, Pittsburgh, PA 15213–2583.
Modal dynamics in multimode fibers (2012)

The dynamics of modes and their states of polarizations in multimode fibers as a function of time, space, and wavelength are experimentally and theoretically investigated. The results reveal that the states of polarizations are displaced in Poincaré sphere representation when varying the angular orientations of the polarization at the incident light. Such displacements, which complicate the interpretation of the results, are overcome by resorting to modified Poincaré sphere representation. With such modification it should be possible to predict the output modes and their state of polarization when the input mode and state of polarization are known.
Aligning Coronary Anatomy and Myocardial Perfusion Territories (2012)

We present a vascular territory distribution model developed for the CORE320 multicenter study, which accounts for variability in coronary anatomy and potential myocardial perfusion territory overlap.
Recombinant Factor VIIa: clinical applications for an intravenous hemostatic agent with broad-spectrum potential (2004)

Recombinant Factor VIIa (NovoSeven, Novo Nordisk) is a unique hemostatic agent with potential for broad-spectrum applications in bleeding patients with congenital and acquired bleeding abnormalities. At present, recombinant Factor VIIa is only approved for the treatment of hemophilia A and B patients who have acquired antibodies to Factors VIII and IX. However, the literature is rapidly expanding indicating that rFVIIa could benefit patients with bleeding due to a variety of etiologies. Unfortunately, the vast majority of these reports are case studies or small-series summaries, and are neither prospective nor controlled. Controlled trials are currently underway in several potential areas of application. While the possibility of thrombotic complications has been a clinical concern, safety data on patients treated to date have not revealed a significant problem. Expansion of the clinical applications for this interesting and important hemostatic agent are hampered by its expense, the limited scope of the US Food and Drug Administration approval for its use, and the absence of an appropriate laboratory monitoring assay.
A Dependency-Based Neural Network for Relation Classification (2015)

Previous research on relation classification has verified the effectiveness of using dependency shortest paths or subtrees. In this paper, we further explore how to make full use of the combination of these dependency information. We first propose a new structure, termed augmented dependency path (ADP), which is composed of the shortest dependency path between two entities and the subtrees attached to the shortest path. To exploit the semantic representation behind the ADP structure, we develop dependency-based neural networks (DepNN): a recursive neural network designed to model the subtrees, and a convolutional neural network to capture the most important features on the shortest path. Experiments on the SemEval-2010 dataset show that our proposed method achieves state-of-art results.
Planar transmission line resonators from YBa/sub 2/Cu/sub 3/O/sub 7-x/ thin films and epitaxial SIS multilayers (1993)

The authors have grown c-axis-oriented YBa/sub 2/Cu/sub 3/O/sub 7-x/ (YBCO) thin films and epitaxial YBCO/NdAlO/sub 3//YBCO trilayers by sputtering. From the YBCO films, coplanar half-wavelength transmission line resonators were patterned. At 77 K the unloaded quality factors of coplanar stripline resonators were up to 2570 at 5.6 GHz. The attenuation constant of such a line was evaluated to be 0.6 dB/m at 77 K and at 5.6 GHz. Coplanar waveguide resonators yielded quality factors up to 1200 at 77 K and at 6.2 GHz resulting in an attenuation constant of 1.8 dB/m. From these measurements the surface resistance values R/sub S/ of the films were determined. The lowest R/sub S/ was 105 mu Omega at 77 K and at 6.2 GHz. Trilayer structures with a dielectric as thick as 800 nm were patterned into microstrip resonators. At 50 K the authors measured a quality factor of 85 at 4.7 GHz, resulting in an attenuation of 26 dB/m and a surface resistance of 340 mu Omega . For thick dielectrics the upper YBCO film already contains significant portions of polycrystalline material.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Embedded Optical Sensors for Thermal Barrier Coatings (2005)

In the second year of this program on developing embedded optical sensors for thermal barrier coatings, our research has focused three topics: (1) Eu{sup 3+} doping for temperature sensing, (2) the effect of long-term, high-temperature aging on the characteristics of the luminescence from the Eu{sup 3+} ions of 8YSZ materials, (3) construction of a fiber-optic based luminescence detector system. It has been demonstrated that the variation in luminescence lifetime with temperature is identical for electron-beam evaporated Eu-doped YSZ coatings as for bulk ceramics of the same composition. Experiments indicate that the luminescence lifetime method of measuring temperatures is sensitive up to 1150 C for both Eu-doped YSZ coatings and Eu-doped Gd{sub 2}Zr{sub 2}O{sub 7}. Furthermore, the technique is sensitive up to 1250 C for the composition Eu{sub 2}Zr{sub 2}O{sub 7}. The luminescence spectra Eu-doped YSZ are insensitive to long-term aging at high-temperatures, even to 195 hours at 1425 C, except for a small frequency shift that is probably too small in measure except with instruments of the highest spectral resolution. The temperature of 1425 C is much higher than present engines attain or even planned in the foreseeable future. Nevertheless, experiments are on-going to explore longer term exposures. A fiber-optic based luminescence system has been constructed in which the hottest section of fiber operates to at least 1250 C.
Pyrene-Functionalized Ruthenium Nanoparticles as Effective Chemosensors for Nitroaromatic Derivatives (2009)

Pyrene-functionalized Ru nanoparticles were synthesized by olefin metathesis reactions of carbene-stabilized Ru nanoparticles with 1-vinylpyrene and 1-allylpyrene (the resulting particles were denoted as Ru=VPy and Ru=APy, respectively) and examined as sensitive chemosensors for the detection of nitroaromatic compounds, such as 2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (2,4-DNT), 2,6-dinitrotoluene (2,6-DNT), 1-chloro-nitrobenzene (CNB), and nitrobenzene (NB), by their effective quenching of the nanoparticle fluorescence. It was found that the detection sensitivity increased with increasing nitration of the molecules. Additionally, in comparison to monomeric pyrene derivatives, both Ru=VPy and Ru=APy nanoparticles exhibited markedly enhanced performance in the detection of nitroaromatic explosives, most probably as a result of the enhanced collision frequency between the fluorophores and the quencher molecules. Furthermore, Ru=VPy nanoparticles displayed much higher sensitivity (down to the nanomolar regime for TNT) than Ru=APy in the detection of these nitroaromatic explosives, which was ascribed to the extended intraparticle conjugation that provided efficient pathways for energy/electron transfer and consequently amplified the analyte binding events.
Genome Sequence of the Oleaginous Yeast <i>Rhodotorula glutinis</i> ATCC 204091 (2014)

Rhodotorula glutinis ATCC 204091 is an oleaginous oxidative red yeast that can accumulate lipids to >50% of its biomass when grown with appropriate carbon and nitrogen ratios. It produces a red pigment consisting of useful antioxidants, such as carotenoids, torulene, and torularhodin, when cultivated under carbon-deficient conditions.
Japanese Experience with Ventricular Assist Devices (1986)

Fundamental and applied studies, recently and currently being done in Japan, in regard of the department of ventricular assist devices are briefly summarized from the engineering standpoint. Present status of the development of blood pumps and their materials, design of control drive systems for pneumatic drive and permanently implantable, electromechanical actuators, and fundamental studies of the effects of ventricular assist on the hemodynamics and cardiac mechanics are described. Clinical cases of the application of ventricular assist devices are also documented.
Targeted Drug Delivery Utilizing Protein-Like Molecular Architecture (2007)

Nanotechnology-based drug delivery systems (nanoDDSs) have seen recent popularity due to their favorable physical, chemical, and biological properties, and great efforts have been made to target nanoDDSs to specific cellular receptors. CD44/chondroitin sulfate proteoglycan (CSPG) is among the receptors overexpressed in metastatic melanoma, and the sequence to which it binds within the type IV collagen triple-helix has been identified. A triple-helical "peptide-amphiphile" (alpha1(IV)1263-1277 PA), which binds CD44/CSPG, has been constructed and incorporated into liposomes of differing lipid compositions. Liposomes containing distearoyl phosphatidylcholine (DSPC) as the major bilayer component, in combination with distearoyl phosphatidylglycerol (DSPG) and cholesterol, were more stable than analogous liposomes containing dipalmitoyl phosphatidylcholine (DPPC) instead of DSPC. When dilauroyl phosphatidylcholine (DLPC):DSPG:cholesterol liposomes were prepared, monotectic behavior was observed. The presence of the alpha1(IV)1263-1277 PA conferred greater stability to the DPPC liposomal systems and did not affect the stability of the DSPC liposomes. A positive correlation was observed for cellular fluorophore delivery by the alpha1(IV)1263-1277 PA liposomes and CD44/CSPG receptor content in metastatic melanoma and fibroblast cell lines. Conversely, nontargeted liposomes delivered minimal fluorophore to these cells regardless of the CD44/CSPG receptor content. When metastatic melanoma cells and fibroblasts were treated with exogeneous alpha1(IV)1263-1277, prior to incubation with alpha1(IV)1263-1277 PA liposomes, to potentially disrupt receptor/liposome interactions, a dose-dependent decrease in the amount of fluorophore delivered was observed. Overall, our results suggest that PA-targeted liposomes can be constructed and rationally fine-tuned for drug delivery applications based on lipid composition. The selectivity of alpha1(IV)1263-1277 PA liposomes for CD44/CSPG-containing cells represents a targeted-nanoDDS with potential for further development and application.
Studies on Ketene and its Derivatives. V. Reaction of Diketene with Quinoline N-Oxide. (1964)

Reaction of quinoline 1-oxide with diketene results in the formation of 2-(2-quinolyl)-methyl-6-methyl-4H-pyran-4-one (III) in 20% yield, together with formation of quinaldine as a by-product. Hydrolysis of III gives quinaldine, acetone, carbondioxide and acetic acid. Reaction of III with liquid ammonia affords 2-(2-quinolyl) methyl-6-methyl-4(1H)-pyridone (IV). Treatment of IV with phosphoryl chloride gives 2-(2-quinolyl)-methyl-4-chloro-6-methylpyridine (V). Similarly, 2-(4-chloro-2-quinolyl) methyl-6-methyl-4H-pyran-4-one (VI) is prepared from 4-chloroquinoline 1-oxide in 16% yield. The reaction mechanism is discussed in this report.
Advanced Hydrogen Production through Methane Cracking: A Review (2015)

Hydrogen is widely produced and used for our day-to-day needs. It has also the potential to be used as fuel for industry or can be used as an energy carrier for stationary power. Hydrogen can be produced by different processes like from fossil fuels (Steam methane reforming, coal gasification, cracking of natural gas); renewable resources (electrolysis, wind, etc.); nuclear energy (thermochemical water splitting). In this paper, few processes have been discussed briefly. Cracking of methane has been given special emphasis in this review for production of hydrogen. There are mainly two types of cracking, non-catalytic and catalytic. Catalytic cracking of methane is governed mainly by finding a suitable catalyst; its generation, deactivation, activation and filament formation for the adsorption of carbon particles (deposited on metal surface); study of metallic support which helps in finding active sites of the catalyst for the reaction to proceed easily. Non-catalytic cracking of methane is mainly based on thermal cracking. Moreover, several thermal cracking processes with their reactor configurations have been discussed.
An efficient exact approach for the constrained shortest path tour problem (2019)

Given a directed graph with non-negative arc lengths, the Constrained Shortest Path Tour Problem (CSPTP) is aimed at finding a shortest path from a single-origin to a single-destination, such that a sequence of disjoint and possibly different-sized node subsets are crossed in a given fixed order. Moreover, the optimal path must not include repeated arcs. In this paper, for the CSPTP we propose a new mathematical model and a new efficient Branch & Bound method. Extensive computational experiments have been carried out on a significant set of test problems in order to evaluate empirically the performance of the proposed approach.
SPATIAL SUMMATION STUDIES (1968)

To the Editor. —Doctor David Cogan was kind enough to call my attention to an article by Doctor M. G. Meur, Etude des sommations spatiales retiniennes dans les amblyopies fonctionelles, published in the Bulletin de la Societe Belge d' Ophthalmologie ( 138: 377-383, 1964). Doctor Meur's results in studying the spatial summation in a group of amblyopes were very similar to mine. In searching the literature on the subject of spatial summation, I simply failed to discover his article. I freely admit Doctor Meur's priority in making these observations and have informed him of this by letter. Please accept my apologies to you and the readers of the Archives for this oversight.
Fluorescence of 1,3,7,9-Tetramethyluric Acid Complexes of Aromatic Hydrocarbons (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorescence of 1,3,7,9-Tetramethyluric Acid Complexes of Aromatic HydrocarbonsB. L. Van DuurenCite this: J. Phys. Chem. 1964, 68, 9, 2544–2553Publication Date (Print):September 1, 1964Publication History Published online1 May 2002Published inissue 1 September 1964https://pubs.acs.org/doi/10.1021/j100791a026https://doi.org/10.1021/j100791a026research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Conformational restriction of angiotensin II: cyclic analogs having high potency (1990)

Cyclic analogues of angiotensin II (AII) were synthesized by connecting the side chains of residues 3 and 5 via a disulfide bridge. Appropriate conformational constraints afforded an analogue, [Hcy3,5]AII, having high contractile activity (pD2 = 8.48 vs 8.81 for AII) and excellent binding affinity (IC50 = 2.1 nM vs 2.2 nM for AII). This type of cyclization was also used to prepare a highly potent AII antagonist, [Sar1,Hcy3,5,Ile8]AII (pA2 = 9.09 vs 9.17 for [Sar1, Ile8]AII; IC50 = 0.9 nM vs 1.9 nM for [Sar1,Ile8]AII). Model building suggests that this ring structure is consistent with a receptor-bound conformation having any of a variety of three-residue turns, including a gamma-turn. In contrast, the receptor-bound conformation of AII does not appear to accommodate a beta-turn or an alpha-helix which includes residues 3-5.
[Studies on fingerprints of Bupleurum chinense from Hebei Province with HPLC-UV]. (2006)

It is simple and quick to differ Bupleurum chinense from different habitats with the method that can be used as a quality control item for Radix Bupleuri.
Optoelectronics (1986)

Although devices that combine light with electronics are by no means new, the name 'optoelectronics' is recently coined. The same revolution that replaced the valve with the transistor, and subsequently complex transistor circuits with integrated circuits, produced an increase in the number and types of devices combining light and electronics. The term 'optoelectronic' came into use as a description for what has now become a large and important branch of electronics technology.