gebhart/patrepeval huggingface dataset:
In silico selection of functional RNA molecules. (2004)

Ribonucleic acid (RNA) molecules combine the coding potential of deoxyribonucleic acid (DNA) with various outwardly visible functions. RNA can be considered as a molecular unit of genotype and phenotype, and this concept has led to the hypothesis of a prebiotic world entirely dominated by RNA. In the postbiotic world, RNA is involved in all of the vital steps of information transfer from genes to gene products, and might intervene in gene expression and many other biological functions, either positively or negatively. RNA molecules have demonstrated tremendous potential as drug targets and drug candidates in the pharmaceutical and biotechnology industries, and are key components in a number of important processes, including microarray-based transcriptome analyses, functional target validation using antisense nucleic acids or short-interfering RNA (siRNA), and RNA-based drug development. The success of these significant but costly processes depends upon intelligent functional RNA design and the development of high-throughput compatible in silico selection tools and filters.
Human haematopoietic stem/progenitor cells express several functional sex hormone receptors (2015)

Evidence has accumulated that murine haematopoietic stem/progenitor cells (HSPCs) share several markers with the germline, a connection supported by recent reports that pituitary and gonadal sex hormones (SexHs) regulate development of murine HSPCs. It has also been reported that human HSPCs, like their murine counterparts, respond to certain SexHs (e.g. androgens). However, to better address the effects of SexHs, particularly pituitary SexHs, on human haematopoiesis, we tested for expression of receptors for pituitary SexHs, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL), as well as the receptors for gonadal SexHs, including progesterone, oestrogens, and androgen, on HSPCs purified from human umbilical cord blood (UCB) and peripheral blood (PB). We then tested the functionality of these receptors in ex vivo signal transduction studies and in vitro clonogenic assays. In parallel, we tested the effect of SexHs on human mesenchymal stromal cells (MSCs). Finally, based on our observation that at least some of the UCB-derived, CD45(-) very small embryonic-like stem cells (VSELs) become specified into CD45(+) HSPCs, we also evaluated the expression of pituitary and gonadal SexH receptors on these cells. We report for the first time that human HSPCs and VSELs, like their murine counterparts, express pituitary and gonadal SexH receptors at the mRNA and protein levels. Most importantly, SexH if added to suboptimal doses of haematopoietic cytokines and growth factors enhance clonogenic growth of human HSPCs as well as directly stimulate proliferation of MSCs.
A Psychological Interpretation of Schopenhauer's Theory of Music (1941)

Research Article| August 01 1941 A Psychological Interpretation of Schopenhauer's Theory of Music Carroll C. Pratt Carroll C. Pratt Search for other works by this author on: This Site PubMed Google Scholar Bulletin of the American Musicological Society (1941) 5: 8–10. https://doi.org/10.2307/829429 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Carroll C. Pratt; A Psychological Interpretation of Schopenhauer's Theory of Music. Bulletin of the American Musicological Society 1 August 1941; 5 8–10. doi: https://doi.org/10.2307/829429 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentJournal of the American Musicological Society Search This content is only available via PDF. Copyright 1941 Arthur Mendel Article PDF first page preview Close Modal You do not currently have access to this content.
Teaching Social Group Work Skills (1998)

This paper discusses areas important to faculty who teach group work courses, student feedback, and their perceptions. The focus is on quality teaching experiences. This will enhance the quality of group work practitioners in the private sector.
An Integrated-Circuit Film-Footage Counter (1969)

When the motion-picture production division of the Instructional Media Center at Michigan State University moved its entire production facility to a new building, the sound installation was completely disassembled and reassembled. Certain new systems were installed at the time, such as a reversible selsyn interlock system. However, it soon became evident that the mechanical, synchronous motor-driven footage counter located in the mixing console would no longer be adequate due to its inability to reverse direction. The integrated-circuit module seemed to be the best alternative system, so an up-down four-digit counter with numerical readout was designed and constructed, which would silently count actual film footage or time. Several other functions were incorporated in the counter design.
MiR-26a Inhibits Cell Growth and Tumorigenesis of Nasopharyngeal Carcinoma through Repression of EZH2 (2011)

Several microRNAs (miRNA) have been implicated in nasopharyngeal carcinoma (NPC), a highly invasive and metastatic cancer that is widely prevalent in southern China. In this study, we report that microRNA miR-26a is commonly downregulated in NPC specimens and NPC cell lines with important functional consequences. Ectopic expression of miR-26a dramatically suppressed cell proliferation and colony formation by inducing G(1)-phase cell-cycle arrest. We found that miR-26a strongly reduced the expression of EZH2 oncogene in NPC cells. Similar to the restoring miR-26 expression, EZH2 downregulation inhibited cell growth and cell-cycle progression, whereas EZH2 overexpression rescued the suppressive effect of miR-26a. Mechanistic investigations revealed that miR-26a suppressed the expression of c-myc, the cyclin D3 and E2, and the cyclin-dependent kinase CDK4 and CDK6 while enhancing the expression of CDK inhibitors p14(ARF) and p21(CIP1) in an EZH2-dependent manner. Interestingly, cyclin D2 was regulated by miR-26a but not by EZH2, revealing cyclin D2 as another direct yet mechanistically distinct target of miR-26a. In clinical specimens, EZH2 was widely overexpressed and its mRNA levels were inversely correlated with miR-26a expression. Taken together, our results indicate that miR-26a functions as a growth-suppressive miRNA in NPC, and that its suppressive effects are mediated chiefly by repressing EZH2 expression.
An Efficient Algebraic Solution to the Perspective-Three-Point Problem (2017)

In this work, we present an algebraic solution to the classical perspective-3-point (P3P) problem for determining the position and attitude of a camera from observations of three known reference points. In contrast to previous approaches, we first directly determine the cameras attitude by employing the corresponding geometric constraints to formulate a system of trigonometric equations. This is then efficiently solved, following an algebraic approach, to determine the unknown rotation matrix and subsequently the cameras position. As compared to recent alternatives, our method avoids computing unnecessary (and potentially numerically unstable) intermediate results, and thus achieves higher numerical accuracy and robustness at a lower computational cost. These benefits are validated through extensive Monte-Carlo simulations for both nominal and close-to-singular geometric configurations.
Modulation of expression of the anti‐inflammatory cytokines interleukin‐13 and interleukin‐10 by interleukin‐3 (1996)

Interleukin (IL)-4, IL-10 and IL-13 are cytokines with potent anti-inflammatory activities. Prevention of pathological inflammation at mucosal surfaces appears to be due, in part, to the presence of these cytokines. One potential source for these cytokines is the mast cell which resides at mucosal surfaces. Demonstrated in this report are the findings that bone marrow-derived mucosal-like mast cells constitutively expressed IL-13 whereas bone marrow-derived connective tissue-like mast cells demonstrated IL-13 transcription only after Fc epsilon RI-mediated activation or the addition of exogenous IL-3. A similar pattern of expression of IL-10 by these mast cell types was also evident and matches that of IL-4 previously reported. Intracellular cytokine staining indicated that IL-10 protein is constitutively expressed by the bone marrow-derived mucosal-like mast cells but is only evident in the bone marrow-derived connective tissue-like mast cells after induction with IL-3. The increase of IL-13 and IL-10 transcripts in the connective tissue-like mast cells following IL-3 treatment is not mast cell specific, in that splenic and bone marrow cells also demonstrated the same phenomenon. These data suggest that mucosal mast cells may have a constitutive repertoire of Th2 cytokines with potential anti-inflammatory activity, while connective tissue mast cells may not. However, production of such cytokines can be induced in the connective tissue mast cell and other cell types of the immune response by the addition of IL-3.
Experimental evaluation of distributed middleware with a virtualized Java environment (2011)

The correctness and performance of large scale service oriented systems depend on distributed middleware components performing various communication and coordination functions. It is, however, very difficult to experimentally assess such middleware components, as interesting behavior often arises exclusively in large scale settings, but such deployments are costly and time consuming. We address this challenge with Minha, a system that virtualizes multiple JVM instances within a single JVM while simulating key environment components, thus reproducing the concurrency, distribution, and performance characteristics of the actual system. The usefulness of Minha is demonstrated by applying it to the WS4D Java stack, a popular implementation of the Devices Profile for Web Services (DPWS) specification.
Anion-tuned supramolecular gels: a natural evolution from urea supramolecular chemistry (2010)

This tutorial review looks at the formation of low molecular weight gels from molecular principles using the well-explored supramolecular chemistry of ureas as an example. Synthesising lessons learned from classical urea inclusion chemistry, ureas in crystal engineering, ureas in self-assembly, urea functional groups in anion binding and sensing, and ureas as organocatalysts lead to the development and understanding of a new class of anion-tunable, urea-based soft materials. This review concludes with a look at emerging application areas for tunable gel-phase materials as controlled crystal growth media, both in templating metallic nanoparticles and in the growth and isolation of high quality crystals of molecular organic compounds, including polymorphic pharmaceuticals.
Effects of chromium picolinate on body composition. (1995)

It was concluded that chromium picolinate was ineffective in enhancing body fat reduction in this group and could not be recommended as an adjuvant to Navy weight-loss programs in general.
Circulating cellfree Fc gamma 2b/gamma 1 receptor in normal mouse serum: its detection and specificity. (1984)

By using intact or Fab fragments of rat monoclonal antibodies against murine Fc gamma 2b/gamma 1 receptor, in a solid phase radioimmunoassay, we demonstrated the occurrence of circulating cellfree Fc gamma 2b/gamma 1 receptors (Cf-Fc gamma 2b/gamma 1R) in normal mouse serum. These Cf-Fc gamma 2b/gamma 1R were removed from serum by affinity chromatography by using Sepharose columns coupled with IgG but not by Sepharose coupled with F(ab')2 fragments. Furthermore, the material retained by and eluted from the Sepharose IgG column reacted with the monoclonal antibody; these results support a direct relationship between the antigenic and the functional Cf-Fc gamma 2b/gamma 1R that were detected in serum. This Cf-Fc gamma 2b/gamma 1R was found in all the 39 normal mouse sera that were tested. The results seemed to indicate that aging may be associated with increased levels of Cf-Fc gamma 2b/gamma 1R and that levels of circulating Fc gamma R may be under genetic regulation. By forming complexes with circulating IgG within the blood stream, such Cf-Fc gamma 2b/gamma 1R may modulate some of the functions in which the Fc portion of Ig is involved.
Technical Progress of China＇s Delayed Coking Technology (2005)

This article introduces the recent advances of China in the fields of process technology of delayed coking, enlarged equipment size, hydraulic decoking, automatic control and environmental protection. By the end of 2004 the total capacity of delayed coking units in China had reached 37.24Mt/a with the maximum coke drum diameter equating to 9.4 m. This article also presents the investment in delayed cokers and the current production status while pointing out the existing problems and future development trends.
Pattern recognition (2014)

Most people like to believe they judge others on their merits, and not by their gender or ethnicity. Neuroscience has shown this isn't always the case, so what can we do about it?
Mutations in PRPF31 Inhibit Pre-mRNA Splicing of Rhodopsin Gene and Cause Apoptosis of Retinal Cells (2005)

Mutations in human PRPF31 gene have been identified in patients with autosomal dominant retinitis pigmentosa (adRP). To begin to understand mechanisms by which defects in this general splicing factor cause retinal degeneration, we examined the relationship between PRPF31 and pre-mRNA splicing of photoreceptor-specific genes. We used a specific anti-PRPF31 antibody to immunoprecipitate splicing complexes from retinal cells and identified the transcript of rhodopsin gene (RHO) among RNA species associated with PRPF31-containing complexes. Mutant PRPF31 proteins significantly inhibited pre-mRNA splicing of intron 3 in RHO gene. In primary retinal cell cultures, expression of the mutant PRPF31 proteins reduced rhodopsin expression and caused apoptosis of rhodopsin-positive retinal cells. This primary retinal culture assay provides an in vitro model to study photoreceptor cell death caused by PRPF31 mutations. Our results demonstrate that mutations in PRPF31 gene affect RHO pre-mRNA splicing and reveal a link between PRPF31 and RHO, two major adRP genes.
Pneumocystis carinii pneumonia following 5-fluorouracil administration. (1987)

A 54-year-old man who had been treated with monthly courses of 5-fluorouracil for one year developed Pneumocystis carinii pneumonia. No evidence of significant, permanent, immunologic impairment was evident one year after the patient became infected. An infection associated with 5-fluorouracil treatment is implicated.
Disrupting Insulin-Like Growth Factor Signaling as a Potential Cancer Therapy (2008)

The type I insulin-like growth factor receptor (IGF-IR) plays multiple roles in several cancers and increased circulating levels of insulin-like growth factor-I (IGF-I) are associated with increased risk of breast, colon, and prostate cancers. Because IGF-II and insulin signal via the insulin receptor (IR) to stimulate the growth of cancer cells, inhibition of IR might be necessary to totally disrupt the action of IGFs and their receptors. This review describes the well-recognized roles of IGF-IR in driving the malignant phenotype, examines the evidence that perhaps IR should also be targeted to inhibit the effects of the IGF ligands and insulin in cancer, describes the strategies to disrupt IGF signaling in cancer, and highlights some key issues that need to be considered as clinical trials targeting IGF-IR proceed.
An enhancement to polypyrrole/chloride ion sensor performance (1996)

A statistical pattern recognition technique is adopted for conducting polypyrrole chloride ion detector to classify ions existing in the operational environment. Four different variables (voltage, current, mass and resistance) were fed to the computer program as three different sets of data for the three different solutions used during the experiment. Using discriminant analysis algorithm, the polymeric system is now capable of recognizing the type of unknown solutions.
Cysteine cathepsins: From structure, function and regulation to new frontiers (2011)

It is more than 50 years since the lysosome was discovered. Since then its hydrolytic machinery, including proteases and other hydrolases, has been fairly well identified and characterized. Among these are the cysteine cathepsins, members of the family of papain-like cysteine proteases. They have unique reactive-site properties and an uneven tissue-specific expression pattern. In living organisms their activity is a delicate balance of expression, targeting, zymogen activation, inhibition by protein inhibitors and degradation. The specificity of their substrate binding sites, small-molecule inhibitor repertoire and crystal structures are providing new tools for research and development. Their unique reactive-site properties have made it possible to confine the targets simply by the use of appropriate reactive groups. The epoxysuccinyls still dominate the field, but now nitriles seem to be the most appropriate "warhead". The view of cysteine cathepsins as lysosomal proteases is changing as there is now clear evidence of their localization in other cellular compartments. Besides being involved in protein turnover, they build an important part of the endosomal antigen presentation. Together with the growing number of non-endosomal roles of cysteine cathepsins is growing also the knowledge of their involvement in diseases such as cancer and rheumatoid arthritis, among others. Finally, cysteine cathepsins are important regulators and signaling molecules of an unimaginable number of biological processes. The current challenge is to identify their endogenous substrates, in order to gain an insight into the mechanisms of substrate degradation and processing. In this review, some of the remarkable advances that have taken place in the past decade are presented. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome.
Low temperature synthesis of Al-AlN composites from a nanostructure made by controlled magneto-ball milling of Al in ammonia (1994)

The formation of an AlN compound in ball milled Al powder in ammonia was studied. In this work a magneto-ball milling device with controlled ball movement was used. The end milling product was an Al based nanostructure. This product can be transformed into an AlN-Al nanocomposite upon heating below the melting point of Al. It was found that the level of unreacted Al is dependent on milling time. The maximum amount of AlN was 88.28 wt %. The structure of as-milled and annealed samples was investigated using x-ray diffractometry and transmission electron microscopy. Differential thermal analysis was performed on as-milled samples.
Comparative Investigation on Fuel Feed Methods in Two-Stroke Cycle Methanol Engine (1992)

<div class="htmlview paragraph">A direct fuel-injection two-stroke cycle engine operated with neat methanol was investigated. The engine performance, combustion and exhaust-gas characteristics were analyzed experimentally and compared for operation with a carburetor, EFI injection at the intake manifold, and EFI injection at the scavenging port.</div> <div class="htmlview paragraph">The power and the brake thermal efficiency of the direct fuel-injection engine were higher than those of engines operated with a carburetor and either of the two EFI methods.</div> <div class="htmlview paragraph">The exhausted unburnt fuel of the direct fuel-injection engine was lower than that for operation with a carburetor, and formaldehyde and the CO concentration were of the same level as for operation with the carburetor and EFI methods. The NO<sub>x</sub> concentration of the direct fuel-injection was half the level of the result of carburetor operation. Because a stratified charge using direct fuel-injection activated the combustion of the lean mixture which increases working gas temperature, therefore, the vaporization of injected fuel was promoted by the elevated temperature of the residual gas.</div>
New balloon catheter for prolonged percutaneous transluminal coronary angioplasty and bypass flow in occluded vessels (1986)

A new balloon catheter was developed for continuous perfusion of coronary arteries during angioplasty (CPC catheter). Steerable Grüntzig balloon catheters (3.7 mm) with two lumina were formed. The first lumen was used for balloon inflation. Side holes to the second lumen proximally and distally to the balloon were created for coronary perfusion even during inflation phase. At a perfusion pressure of 120 mmHg, a flow rate of 63 +/- 3 ml/min with 0.9% saline and 43 +/- 1 ml/min with plasma expander were measured. In experiments on five dogs, dilation time until appearance of signs of ischemia could be prolonged in three of five dogs from 30 to 40 s, 120 to 203 s, and 180 to 420 s comparing conventional and CPC balloon catheters. In 11 patients with proximal lesions, dilation time could be increased from 39.5 +/- 23.9 s to 81.1 +/- 36.3 s (p less than 0.01) until appearance of angina pectoris. ST segment changes were observed in 10/11 patients using conventional catheters. Using CPC catheters, no ST segment changes were observed in four patients; time until appearance of ST segment changes was delayed in the other seven patients. The CPC catheter seems to be an alternative catheter in proximal lesions of the left and right coronary artery, allowing the possibility of prolonged dilation and increased safety to the patient. In case of dissection or perforation, the CPC catheter can be used for perfusion of the distal part of the coronary vessel until emergency bypass surgery.
Synthesis of Potential Anti-HIV GP120 Inhibitors Using a Lysine Template (2002)

Various acylated proteins have been reported in the literature to possess anti-HIV activity. Described here is the preparation of lysine monomers, dimers and trimers acylated with various anhydrides and dioxalanones as simplified mimics of the acylated proteins. Compounds were assayed against HIV-infected C8166 cells and some showed weak anti-HIV activity.