gebhart/patrepeval huggingface dataset:
Abstract 2950: Distinct Regulation of Cardiac Function by Histone Deacetylase Inhibitors in Response to Pressure Overload (2008)

Background- Recent work has uncovered that histone acetylation might work as a nodal control point in the complex signal network for gene regulation in hypertrophic myocardium, moreover, histone deacetylase (HDAC)inhibitors might hold promise as potential therapeutic agents in hypertrophic heart disease. In this study, we tested the effects of some HDAC inhibitors on hypertrophy and subsequent cardiac dysfunction in response to pressure overload. Method and results- Transverse aortic constriction (TAC) operation were performed on C57BL/6J mice and pressure overload was successfully produced. Cardiac hypertrophy and dysfunction induced by TAC for 6 weeks were significantly blunted by trichostatin A (TSA) and valproic acid (VPA). In contrast, treatment by 4-Sodium phenylbutyrate (4-PBA) unexpectedly further exaggerated cardiac remodeling at week 6 compared with vehicle-treated mice, indicated by larger ratio of heart weight to body weight, bigger cross-sectional area and more enlarged left ventricle (LV) dimension. 4-PBA also led to lower ejection fraction and fractional shortening. Moreover, invasive hemodynamic measurements showed significantly higher LV end diastolic pressure (31.0 vs 15.5 mmHg, p<0.001) and lower contractivity index (120.8 vs 160.4, p<0.01) compared with vehicle-treated mice, suggesting the deterioration of diastolic and systolic function. In accordance with these data, the expressions of hypertrophic markers were further increased by 4-PBA administration. Kaplan-Meier analysis revealed significantly lower survival rate in 4-PBA-treated mice (32.7% vs 66.7%, p<0.001). Similarly, treatment with butyrate acid (BS), an analogue of 4-PBA, also achieved unbeneficial effect. All the 4 HDAC inhibitors successfully inhibited HDAC total activity in vivo and in vitro . Individual HDAC activity assay showed rather than class IIa members (HDAC 4 and 7), 4-PBA and BS predominantly inhibit class IHDACs (HDAC2 and 8), whereas VPA and TSA inhibit them all to a similar extent. Conclusion- Together, these data suggest that 4-PBA and BS accelerate load -induced hypertrophy and cardiac dysfunction, whereas VPA and TSA hold opposing effects. The distinct regulation might be due to differential selectivity on certain HDAC subtypes.
Novel Modular Multiple-Input Bidirectional DC–DC Power Converter (MIPC) for HEV/FCV Application (2014)

This paper proposes a novel multiple-input bidirectional dc-dc power converter to interface more than two dc sources of different voltage levels. This finds applications in hybrid electric/fuel cell vehicles (FCVs), where different dc sources of unequal voltage levels need to be connected with bidirectional power flow capability. The converter can be used to operate in both the buck and boost modes with bidirectional power control. It is also possible to independently control power flow between any two sources when more than two sources are actively transferring power in either directions. The operation, analysis, and design of the converter are presented with different modes of power transfer. The proposed converter is demonstrated for FCV application using real-time hardware-in-the-loop system. Experimental results for a 5-kW system are presented, validating the theoretical analysis.
Neurologic 3D MR Spectroscopic Imaging with Low-Power Adiabatic Pulses and Fast Spiral Acquisition (2011)

The proposed adiabatic spiral 3D MR spectroscopic imaging sequence can be performed in a standard clinical MR environment. Improvements in image quality and imaging time could enable more routine acquisition of spectroscopic data than is possible with current pulse sequences.
Development and testing of a fire-resistant optical cable (1986)

A new type of fire-resistant optical cable has been developed. It is based on the loose tube concept employing special mica and glass tape wrappings together with a new type of buffer jacket material to provide the desired properties. With this design, ordinary acrylate-coated fibers are used. The cable has the unique property that during fire it converts from a cable, which mostly consists of organic materials, to a ceramic loose-tube structure that gives the fiber sufficient protection to prevent damage during fire. The cable has been tested according to IEC 331 which specifies a 750°C flame exposure for 3 h, and passed that test with negligible loss increase even at temperatures up to 900°C.
The application of N-phenyltriflamide to the synthesis of deoxyaspergillic acid (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe application of N-phenyltriflamide to the synthesis of deoxyaspergillic acidRaymond J. Bergeron and Patrick G. HoffmanCite this: J. Org. Chem. 1980, 45, 1, 163–165Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/jo01289a033https://doi.org/10.1021/jo01289a033research-articleACS PublicationsRequest reuse permissionsArticle Views112Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Effect of Atmospheric Turbulence on the Solar Image and Sunspots (1964)

Abstract On the basis of the photoelectric and photographic observations of the solar limb and sunspots, the shape of the scattering function is discllSSed and the proposal is made that it is the sum of two Gaussian functions. The result does not change the previous conclusion that the atmosphere of the sunspot umbra consists of two components, one hot and the other cold. The photoelectric observations give some information as to the size, frequency spectrum, and wave-length dependence of the atmospheric turbulence and, moreover, as to the correlations between the atmospheric turbulence and weather and between observations made with different instruments.
Overexpression of tomato LeAGP‐1 arabinogalactan‐protein promotes lateral branching and hampers reproductive development (2004)

LeAGP-1 is a glycosylphosphatidylinositol (GPI)-anchored arabinogalactan-protein (AGP) in tomato (Lycopersicon esculentum). Patterns of mRNA expression and protein localization for LeAGP-1 indicate that it likely functions in certain aspects of plant growth and development. To elucidate LeAGP-1 function(s), transgenic tomato plants expressing enhanced green fluorescent protein (GFP) fused to LeAGP-1 [GFP-LeAGP-1] or two LeAGP-1 variants, one lacking the C-terminal GPI-anchor domain [GFP-LeAGP-1DeltaC] and the other lacking the lysine-rich domain [GFP-LeAGP-1DeltaK], under the control of the CaMV35S promoter were produced using Agrobacterium-mediated transformation. Transgenic T0 and T1 lines with high levels of both GFP-LeAGP-1 mRNA and protein: (i) were significantly shorter; (ii) were highly branched; (iii) produced more flower buds, but most of these flowers did not mature, resulting in less fruit production; and (iv) produced seeds that were significantly smaller than normal seeds. Overexpression of LeAGP-1DeltaK had a similar or even more pronounced effect on plant vegetative and reproductive growth, while the effect of LeAGP-1DeltaC overexpression on plant reproduction was minimal. These results indicate that the GPI anchor is critical for LeAGP-1 function. As the phenotype of GFP-LeAGP-1 overexpressing transgenic plants is similar to that of cytokinin-overproducing plants, mRNA expression patterns of LeAGP-1 under different hormone treatments were examined. Cytokinins upregulated LeAGP-1 mRNA expression, while auxins and ABA inhibited LeAGP-1 mRNA expression. Based on these results, GPI-anchored LeAGP-1 most likely functions in plant growth and development in concert with auxin/cytokinin signaling.
A rapid, sensitive and automated method for detection of <b> <i>Salmonella</i> </b> species in foods using AG‐9600 AmpliSensor Analyzer (1997)

The AG-9600 AmpliSensor Analyzer is an automated fluorescence-based system for detection of polymerase chain reaction (PCR) products. The principle of the AmpliSensor PCR assay involves amplification-mediated disruption of a fluorogenic DNA signal duplex (AmpliSensor) that is homologous to a target sequence within a 284-bp amplified fragment of the Salmonella invA gene. Since the assay is homogenous, the data can be obtained by direct measurement of fluorescence of the amplification mixture. The accumulation of the amplified product, reflected by the fluorescence index, is monitored cycle by cycle by the AG-9600 Analyzer. The detection limit of the assay was less than 2 colony-forming units (cfu) per PCR reaction using a pure culture of Salmonella typhimurium. In post-spiking experiments in which Salmonella was added to the overnight pre-enriched samples (chicken carcass rinses, ground beef, ground pork and raw milk), the detection limit of the assay was 2-6 cfu per PCR reaction. In pre-spiking experiments in which Salmonella was added to the samples prior to overnight pre-enrichment, the detection limit was less than 3 cfu per 25 g or 25 ml of food. The assay was up to 2 orders of magnitude more sensitive than detection by ethidium bromide-stained agarose gel electrophoresis. To further evaluate assay performance, 54 naturally contaminated chicken carcass rinses, 65 raw milk and six ground pork samples were tested in the study. Thirty-eight Salmonella-positive samples confirmed by the Modified Semi-solid Rappaport-Vassiliadis (MSRV) culture assay were found positive using the AmpliSensor assay. Two chicken carcass rinses found positive using the assay were MSRV-negative. In addition, relative quantification using the AmpliSensor assay was linear up to 3 logs of initial target concentration in artificially contaminated food samples.
Do Salivary Antibodies Reliably Reflect Both Mucosal and Systemic Immunity? (2007)

Two major antibody classes operate in saliva: secretory IgA (SIgA) and IgG. The former is synthesized as dimeric IgA by plasma cells (PCs) in salivary glands and is exported by the polymeric Ig receptor (pIgR). Most IgG in saliva is derived from serum (mainly via gingival crevices), although some is locally produced. Gut-associated lymphoid tissue (GALT) and nasopharynx-associated lymphoid tissue (NALT) do not contribute equally to mucosal PCs throughout the body. Thus, enteric immunostimulation is an inadequate mode of stimulating salivary IgA antibodies, which are poorly associated with the intestinal SIgA response, for instance after enteric cholera vaccination. Nevertheless, the IgA response in submandibular/sublingual glands is better related to B cell induction in GALT than the parotid response. Such disparity is suggested by the elevated levels of IgA in submandibular secretions of AIDS patients, paralleling their highly upregulated intestinal IgA system. Moreover, in patients with active celiac disease, IgA antibodies to disease-precipitating gliadin are reliably represented in whole saliva but not in parotid secretion. Parotid SIgA may be more consistently linked to immune induction in palatine tonsils and adenoids (human NALT), as supported by the homing molecule profile of NALT-derived B cell blasts. Also several other variables influence the levels of antibodies in oral secretions. These include difficulties with reproducibility and standardization of immunoassays, the impact of flow rate, acute or chronic stress, protein loss during sample handling, and uncontrolled admixture of serum-derived IgG and monomeric IgA. Despite such problems, saliva remains an interesting biological fluid with great scientific and clinical potentials.
A &#x0394;&#x03A3; ADC using an LSB-first SAR quantizer (2015)

A ΔΣ ADC using an LSB-first quantizer (LSBFQ) is proposed. LSBFQ are energy-efficient ADCs for processing signals with low activity, and have been proposed as standalone quantizers for sensor and biomedical applications. Since the quantizers in highly oversampled multibit ΔΣ ADC process signals with low average activity, the LSBFQ is an ideal quantizer solution. In order to avoid clocking the LSBFQ at a rate much faster than the rest of the ΔΣ ADC, it is proposed that the quantizer be provided a fixed number of comparison cycles, then be interrupted regardless of whether the conversion has fully completed. This is acceptable because for high oversampling ratios (OSR), the average code change is small and an N-bit conversion can usually be completed in fewer than N comparison cycles. In the rare cases that the quantizer is interrupted early, it injects slightly more quantization noise into the loop filter, which is filtered and shaped with little impact on signal-to-noise and distortion ratio (SNDR). Simulation results demonstrate that for high OSR, an LSBFQ achieves higher resolution and lower capacitor switching energy than a conventional SAR ADC using the same number of comparator bitcycles.
Essential structural elements in tRNAPro for EF-P-mediated alleviation of translation stalling (2016)

The ribosome stalls on translation of polyproline sequences due to inefficient peptide bond formation between consecutive prolines. The translation factor EF-P is able to alleviate this stalling by accelerating Pro-Pro formation. However, the mechanism by which EF-P recognizes the stalled complexes and accelerates peptide bond formation is not known. Here, we use genetic code reprogramming through a flexible in-vitro translation (FIT) system to investigate how mutations in tRNA(Pro) affect EF-P function. We show that the 9-nt D-loop closed by the stable D-stem sequence in tRNA(Pro) is a crucial recognition determinant for EF-P. Such D-arm structures are shared only among the tRNA(Pro) isoacceptors and tRNA(fMet) in Escherichia coli, and the D-arm of tRNA(fMet) is essential for EF-P-induced acceleration of fMet-puromycin formation. Thus, the activity of EF-P is controlled by recognition elements in the tRNA D-arm.
A high density, low on-resistance 700V class trench offset drain LDMOSFET (TOD-LDMOS) (2004)

We present a low on-resistance 700 V class trench offset drain LDMOSFET. A Noffset drain region is formed around the oxide-filled trench whose width and depth are both 20 /spl mu/m. The fabricated MOSFET exhibits a specific on-resistance of 10.4 /spl Omega/ mm/sup 2/, which is about 30% lower than the experimental best record so far.
DC Offset Mitigiation in Homodyne Receiver (2006)

The benefits and implementation issues of the Homodyne Receiver architecture in mobile handsets is presented, with a review of some current techniques used to mitigate the dc-offset generated due to Local-Oscillator (LO) leakage self-mixing, and a simplified solution is investigated.
Tumor-specific methylation patterns of erbB2 (HER2/neu) sequences in gastro-intestinal cancer. (1992)

To determine whether the sporadically occurring amplification of the oncogene erbB2/HER2 in gastrointestinal carcinomas is associated with additional changes of this sequence, DNA from 17 colorectal and 5 stomach carcinomas was analyzed for copy number, sequence rearrangement and DNA methylation by Southern blot hybridization. Amplification was detected in two cases. By applying the isochizomers Hpall and Mspl we tested for alterations in the DNA methylation status. Whereas in colon tumors with non-amplified erbB2 this status was unchanged, one case with erbB2 amplification showed additional MspI bands indicating a methylation of the amplified gene sequences. In stomach carcinoma, however, we detected differences between tumor and mucosa samples but not between amplified and non-amplified tumor samples. Independent of the DNA methylation status, significant amounts of the erbB2 oncoprotein were detected in the cases with gene amplification; weaker immunostaining of erbB2 was also seen in a few additional tumors.
Architectural-level power estimation for system-on-a-chip (1999)

This thesis addresses issue associated with the architectural level power estimation for System-on-a-Chip (SoC) products. A power estimation technique at the architectural level was developed and validated on a commercial single-chip system. The target chip integrates a 16-bit DSP, a 32-bit RISC processor and memories on a single die. The power estimator provides power consumption data of the architecture based onto the instruction/data flow stream. During the implementation of the estimator, a novel technique was developed to estimate the power dissipation of microprocessor control units at the architectural level. We demonstrated the accuracy of the estimator by comparing the power values it produces against measurements made by Hitachi's power simulator for the same benchmark set. The results show that our estimation approaches can provide a more accurate solution than other current approaches. In addition to the research on the target SoC, the issues associated with estimating clock power consumption for general SoC designs were investigated. Also, an analysis scheme for commercial power estimators was established to enhance their accuracy.
Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo (2002)

Plasmin, the primary fibrinolytic enzyme, has a broad substrate spectrum and is implicated in biologic processes dependent upon proteolytic activity, such as tissue remodeling and cell migration. Active plasmin is generated from proteolytic cleavage of the zymogen plasminogen (Plg) by urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). Here, we have investigated the role of plasmin in C2C12 myoblast fusion and differentiation in vitro, as well as in skeletal muscle regeneration in vivo, in wild-type and Plg-deficient mice. Wild-type mice completely repaired experimentally damaged skeletal muscle. In contrast, Plg(-/-) mice presented a severe regeneration defect with decreased recruitment of blood-derived monocytes and lymphocytes to the site of injury and persistent myotube degeneration. In addition, Plg-deficient mice accumulated fibrin in the degenerating muscle fibers; however, fibrinogen depletion of Plg-deficient mice resulted in a correction of the muscular regeneration defect. Because we found that uPA, but not tPA, was induced in skeletal muscle regeneration, and persistent fibrin deposition was also reproducible in uPA-deficient mice following injury, we propose that fibrinolysis by uPA-dependent plasmin activity plays a fundamental role in skeletal muscle regeneration. In summary, we identify plasmin as a critical component of the mammalian skeletal muscle regeneration process, possibly by preventing intramuscular fibrin accumulation and by contributing to the adequate inflammatory response after injury. Finally, we found that inhibition of plasmin activity with alpha2-antiplasmin resulted in decreased myoblast fusion and differentiation in vitro. Altogether, these studies demonstrate the requirement of plasmin during myogenesis in vitro and muscle regeneration in vivo.
Roller Leveler Monitoring Using Acceleration Measurements and Models for Steel Strip Properties (2020)

The advanced steel grades and high productivity requirements in the modern steel industry subject production machines to increased mechanical stresses, which inflicts losses. Novel data-oriented solutions to the monitoring of machines have a pivotal role in loss prevention, but the industrial data with high sampling rates, noise, and dimensions bring challenges there. This study proposes a new monitoring approach for roller levelers based on vibration measurements and regression models for estimating steel strip properties including yield strength, width, and thickness. The regression residuals are monitored based on moving mean and range charts, which reveal changes from the expected normal operation. A high-dimensional feature set of 144,000 statistical features was studied with various feature selection methods, including filters and wrappers. Multiple linear regression and generalized regression neural network were applied in modeling. The approach was validated using data from an industrial roller leveler processing steel strips with diverse properties. The results reveal that the accurate prediction of the strip thickness from the strip properties is possible and multiple linear regression was generally the superior model therein. Additional simulations indicated that the control charts can detect deviant operation. Supplemental information about the momentary operation of the machine would improve the approach.
<title>Color interest points detector for visual information retrieval</title> (2001)

The purpose of our visual information retrieval tool is to extract from a database images that are similar to an image query. Color features are generally used to define a measure of similarity between images, as they are usually very robust to noise, image degradation, changes in size, resolution or orientation. Nevertheless, the most often features suffer objectively from the lack of color spatial knowledge. Then, our purpose is to merge two classical methods : the color pyramid and the interest points detection, well-known for grey level image analysis. The pertinence of this new method is demonstrated by an evaluation and a comparison with others keypoints detectors. We show the interest for image indexation with concrete tests on our large images database, using the icobra system.
Network (2005)

This within subjects test-retest study aimed to determine whether trait anxiety (a general proneness to anxiety) scores and age could predict children’s state anxiety (transitory emotional reaction) scores under stressful and relaxing situations.
CAZAC sequence and its application in LTE random access (2006)

Constant amplitude zero autocorrelation (CAZAC) sequence, which is one type of polyphase codes, has many applications in channel estimation and time synchronization, since it has good periodic correlation properties. Now it is also introduced to long-term evolution (LTE) of 3rd Generation Partnership Project (3GPP) random access procedure as preamble signature. Based on the introduction of CAZAC sequences good periodic correlation, this paper gives a simple detection structure of random access preambles. Simulation results indicate that the proposed detector performs as well as detectors that other companies provided, but has simpler structure
Studies on Chemotherapeutics for Acid-fast Bacilli. XVI (1961)

In order to test the bacteriostatic activity, some compounds related to 4H-1-benzothiopyran-4-one 1, 1-dioxide, a kind of isoster of 1, 4-naphthoquinone, were prepared as illustrated in Chart 1. Contrary to expectations, none of these compounds showed strong activity in vitro against Mycobac. tuberculosis and E. coli. It is supposed that the redox potential of quinones plays an important rôle in their bacteriostatic activity.The half-wave potentials of some typical derivatives were measured by polarography. It was clarified that these compounds, which possessed 3-oxopropenylsulfonyl (-CO-CH=CH-SO2-) structure, showed comparatively positive reduction potential. This result agreed with the fact that 2-(phenylthio)thiochroman-4-one 1, 1-dioxide was easily produced from 3-bromo-4H-1-benzothiopyran-4-one 1, 1-dioxide and thiophenol in alkaline medium.