gebhart/patrepeval huggingface dataset:
Chemotactic Peptide-induced Changes of Intermediate Filament Organization in Neutrophils during Granule Secretion: Role of Cyclic Guanosine Monophosphate (1998)

In neutrophils activated to secrete with formyl-methionyl-leucyl-phenylalanine, intermediate filaments are phosphorylated transiently by cyclic guanosine monophosphate (cGMP)-dependent protein kinase (G-kinase). cGMP regulation of vimentin organization was investigated. During granule secretion, cGMP levels were elevated and intermediate filaments were transiently assembled at the pericortex to areas devoid of granules and microfilaments. Microtubule and microfilament inhibitors affected intermediate filament organization, granule secretion, and cGMP levels. Cytochalasin D and nocodazole caused intermediate filaments to assemble at the nucleus, rather than at the pericortex. cGMP levels were elevated in neutrophils by both inhibitors; however, with cytochalasin D, cGMP was elevated earlier and granule secretion was excessive. Nocodazole did not affect normal cGMP elevations, but specific granule secretion was delayed. LY83583, a guanylyl cyclase antagonist, inhibited granule secretion and intermediate filament organization, but not microtubule or microfilament organization. Intermediate filament assembly at the pericortex and secretion were partially restored by 8-bromo-cGMP in LY83583-treated neutrophils, suggesting that cGMP regulates these functions. G-kinase directly induced intermediate filament assembly in situ, and protein phosphatase 1 disassembled filaments. However, in intact cells stimulated with formyl-methionyl-leucyl-phenylalanine, intermediate filament assembly is focal and transient, suggesting that vimentin phosphorylation is compartmentalized. We propose that, in addition to changes in microfilament and microtubule organization, granule secretion is also accompanied by changes in intermediate filament organization, and that cGMP regulates vimentin filament organization via activation of G-kinase.
Optical properties of aluminium nitride prepared by chemical and plasmachemical vapour deposition (1977)

Aluminium nitride films are produced on fused quartz, silicon, and spinel substrates by reaction of AlCl3 with NH3 or ammonolysis of AlCl3 · NH3 as well as by plasmachemical reaction of AlCl3 with N2 within a range of substrate temperatures of 700 to 1300 °C. The refraction index n, the absorption coefficient α, and the r. m. s.-surface roughness result from optical studies in the spectral range of 3.5 to 7.5 eV. The spectral dependence of optical constants yields a direct band gap Eg = 5.9 to 6.0 eV. Furthermore absorption bands are observed at 4.5 and 5 eV. Moreover some results for structural and electrical characterizing of films are given. Aluminiumnitrid-Schichten werden auf Quarzglas, Silizium- und Spinell-Substraten durch Reaktion von AlCl3 mit NH3 oder Ammonolyse von AlCl3 · NH3 sowie durch plasmachemische Reaktion von AlCl3 mit N2 im Substrattemperaturbereich von 700 bis 1300 °C hergestellt. Aus optischen Untersuchungen im Spektralbereich von 3,5 bis 7,5 eV ergeben sich die Brechzahl n, der Absorptionskoeffizient α und die rms-Rauhigkeit. Die spektrale Abhängigkeit der optischen Konstanten liefert einen direkten Bandabstand von Eg = 5,9 bis 6,0 eV. Außerdem werden Absorptionsbanden bei 4,5 und 5,0 eV beobachtet. Darüber hinaus werden einige Ergebnisse zur strukturellen und elektrischen Charakterisierung der Schichten angegeben.
Biological Markers for the Clinical Diagnosis of Alzheimer's Disease. (1996)

There is a compelling need to develop biological marker(s) to confirm a clinical diagnosis of Alzheimer's disease (AD) during life in order to unequivocally identify AD patients for emerging therapeutic interventions. This review describes recent advances in the development of diagnostic marker(s) for AD. They include polymorphism of apolipoprotein E (ApoE) and alpha 1-antichymotrypsin as well as cerebrospinal fluid (CSF) tau and CSF-amyloid beta-protein levels, skin biopsy, and pupil dilatation assay by anti-cholinergic agent. In conclusion, ApoE genotyping should not be used as a sole diagnostic test for AD, and that monitoring of CSF-tau appeared to be most promising and reliable diagnostic aid.
Dimerization and oligomerization of G-protein-coupled receptors: debated structures with established and emerging functions (2008)

Dimerization or oligomerization of G-protein-coupled receptors (GPCRs) is a novel concept, which may lead to the reevaluation of the actions of pharmacological ligands, hormones, neurotransmitters, and other mediators acting on GPCRs. Although a large number of data obtained using different biophysical, biochemical and structural methods, and functional approaches argue for dimerization or oligomerization of these receptors, several publications criticized the applied methods and challenged the concept. The aim of this paper is to review the data that support the concept of receptor oligomerization, and the most important arguments against it. We conclude that it will require major methodical improvements to obtain decisive proof, whether GPCRs exist in their native membrane environments as homo- or heterodimeric or oligomeric complexes, in which receptor monomers have stable direct interactions. However, overwhelming amounts of data suggest that many GPCRs exhibit functional properties that require direct or indirect interactions between clustered receptors. Although it is difficult to conclude, about the exact nature of these interactions, dimerization or oligomerization of GPCRs is a useful paradigm for pharmacologists to study properties of receptors, which require functionally important clustering of receptors, such as trafficking of newly synthesized receptors to the cell surface, allosteric modulation of ligand binding, signaling specificity, co-internalization, or cross-inhibition of GPCRs.
Immunoglobulin with complementary paratope and idiotope. (1986)

A hybridoma antibody (11E7-1) was isolated from a myeloma fusion with nu/nu BALB/c immunized against the T15 idiotype. This IgM antibody exhibited a dual specificity, binding both to PC and to anti-PC antibodies from two idiotype families. Binding to PC and anti-PC antibodies are completely inhibited by PC analogs. Furthermore, the hybridoma antibody binds to itself. Self-binding is also inhibited by PC analogs. From these data, we suggest that 11E7-1 hybridoma antibody has a PC-specific paratope site, and at same time expresses the internal PC antigen idiotope. The term autobody is proposed to signify its self-binding and potential role in autoimmunity. Autobodies may have a unique role in the network of immune system. Furthermore, it may be a model for designing idiotype vaccines.
Preparation of Poly(4-vinylphenol)/Titanium Dioxide Composite and Its Application as a Gate Dielectric for Organic Thin-Film Transistors (2011)

Organic-inorganic composites can provide a unique feature combining superior dielectric properties of inorganic materials and solution processing capability of organic materials. In this study, poly(4-vinylphenol) (PVP) and titanium dioxide (TiO2) composite was prepared by mixing TiO2 nanoparticles in the PVP solution. In order to avoid severe gate-leakage currents in organic thin-film transistors (OTFTs) with such a composite gate dielectric layer, poly(oxyethylene)(20)-sorbitane monooleate was used as a surfactant for uniform dispersion of TiO2 particles. The dispersion stability of TiO2 nanoparticles in the composite solutions was confirmed by observing its sedimentation time in the composite solutions. The composite dielectric film, fabricated by means of simple spin-coating, provided an enhanced dielectric property and contributed to reducing the threshold voltage of OTFT, without augmenting the gate-leakage current. These results demonstrate that the fabricated composite dielectric film is essentially eligible for low-voltage operating OTFTs.
Flunixin meglumine in calves with natural bovine respiratory syncytial virus infection (1986)

Twenty-three calves (three to eight months of age) with serological evidence of bovine respiratory syncytial virus infection were used in this study. The calves originated from four herds with respiratory tract disease. In a double blind trial the calves were injected intravenously with either flunixin meglumine (2 mg/kg body weight) or with a placebo. The effect on the course of disease was measured using the PO2 in capillary blood samples from the ears of the calves and by the effect on body temperature and respiratory rate. Mean body temperature fell significantly in the flunixin meglumine treated group. Statistically significant differences were not found between the treated and control group during the seven-day examination period.
[Vitamins and therapy of malignancies]. (1994)

Conditioning therapy preceding bone marrow transplantation usually consists of high-dose chemotherapy and total body irradiation. This is associated with acute and delayed toxic effects for several tissues, possibly related to peroxidation processes and exhaustion of antioxidants. Therefore, plasma of 22 patients was examined for alpha- and gamma-tocopherol (vitamin E), the carotenoids beta-carotene and lycopene, retinol, and ascorbic acid before, during and after conditioning chemotherapy for bone marrow transplantation. 18 of the patients received total body irradiation as well. Retinol and ascorbic acid have been given intravenously in a multiple of the recommended doses (Deutsche Gesellschaft für Ernährung (DGE) and Recommended Dietary Allowance (RDA), respectively). The doses chosen were sufficient to maintain the initial plasma concentrations of these vitamins. However, alpha-tocopherol (in RDA doses) and beta-carotene (no RDA established) concentrations deteriorated after the conditioning therapy (20% and 50% loss, respectively). The loss of these lipid-soluble antioxidants has been considered to result from lipid peroxidation, since lipid peroxide concentrations in plasma increased concurrently. On the basis of these results we performed interventions studies in order to investigate the effect of high-dose supplementation on antioxidant status. We compared the loss of antioxidants and the toxicity in two groups of patients undergoing bone marrow transplantation: The first group without and the second group with oral supplementation of high doses of alpha-tocopherol (825 mg daily), ascorbic acid (450 mg daily) and beta-carotene (45 mg daily) for three weeks prior to chemo- and radiotherapy.(ABSTRACT TRUNCATED AT 250 WORDS)
Trajectory Control of Manipulators by On-Line Parameter Identification (1984)

In general, it is very difficult to control motion of mechanical manipulators when their hand grips an unknown object. The reason is that the dynamic characteristics for manipulators vary according to the payload of the object. In this case, mass, center of mass, and inertia tensor of the end link become unknown parameters, while other system parameters do not change.This paper presents a new approach to trajectory control by using adaptive controller. Only unknown parameters are identified by an on-line recursive algorithm based on the least squares error criterion, though this method requires angular acceleration observation. The controller is calculated on-line, using an accurate dynamic model with estimated values for unknown parameters. Simulation results for a six degrees of freedom manipulator show that trajectory errors become very small in spite of the fact that the least square estimate is biased when observation noise of joint angular acceleration exists. The effectiveness of the proposed control method was verified by experimental results obtained for a two degrees of freedom manipulator.
Book Reviews (1957)

Book Reviews Get access An Approach to the Theology of the Sacraments. Studies in Biblical Theology No. 17. By NEVILLE CLARK. Naperville, Illinois: Alec R. Allenson, Inc., 1956. 95 pages, $1.50. JOHN W. BAILEY JOHN W. BAILEY Berkeley Baptist Divinity School Search for other works by this author on: Oxford Academic Google Scholar Journal of the American Academy of Religion, Volume XXV, Issue 2, April 1957, Page 168, https://doi.org/10.1093/jaarel/XXV.2.168 Published: 01 April 1957
An attempt to simulate the bowing phenomenon in tenter with simple models (1993)

Abstract The bowing phenomenon throughout a tenter was experimentally observed with a pilot plant of successive biaxial stretching. The observed results were compared with simulated ones, by which the deformation behaviors of film in a tenter were predicted, with the assumption that the film was homogeneous isotropic, homogeneous anisotropic, heterogeneous isotropic, or heterogeneous anisotropic for a two‐dimensional elastic body with an FEM. Comparatively good agreement between the simulated and observed results was obtained for a heterogeneous anisotropic elastic body with an initial mesh, involving in advance a plastic deformation part. © 1993 John Wiley & Sons, Inc.
Side scan sonar using phased arraysfor high resolution imaging andwide swath bathymetry (1996)

The design of a new bathymetric sidescan sonar dedicated to the survey of the continental shelf is described. It uses linear phased arrays in order to perform dynamically the control of the resolution through the focusing of the beams, and beam steering to compensate for yaw and pitch. The 4 m long array, working at 112 kHz, yields high resolution imaging. In addition, an interferometric doublet, with a 2λ spacing, provides a wide swath bathymetric capability. Both functions take advantage of a fast digital pulse compression process. Results of sea trials with the hull mounted system (high resolution images and topographic maps) are discussed.
Optimization of packaging process of piezoresistive engine oil pressure sensor (2010)

The piezoresistive pressure sensor is one of the major applications of MEMS (Micro-Electro-Mechanical-System) devices. Nowadays, in the field of automotive electronics, silicon-based pressure sensors are playing a significant role in the control of brake, engine, tire pressure, etc. The piezoresistive based engine oil pressure sensor mentioned in this paper is applied to detect the pressure of lubricant of the automobile engine. We firstly study the influence of silicon oil on the offset of pressure sensor. Results show that the offset tends to be relatively large when the amount of the silicon oil increases. In order to minimize the zero offset, ceramic substrate is introduced to reduce the amount of the silicon oil. We also find that the cleanliness and stability of the silicon oil have a considerable impact on the offset. The fully cleaned silicon oil leads to a smaller offset, and few changes are found when temperature increases. The silicon oil with good stability can result in a stable offset even the packaged sensor stored at a high temperature for a long time. Then, the influence of the welding performance of TO base on the hermeticity of pressure sensor is investigated by experimental tests and finite element method (FEM) analysis. Results show that, compared with the iron, Kovar alloy has a better welding performance and the leakage rate of the sealed chamber is less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-8</sup> Pa.m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> /s. FEM analysis fits well with the experimental tests.
Light-induced expansion of fiber tips in near-field scanning optical microscopy (1996)

The emission profiles of laser diodes working at 780 nm and 1300 nm are studied by near-field scanning optical microscopy. As the near-field probe is scanned across the laser mirror facet, the laser emission induces a transient expansion of the probe tip which is monitored using shear force microscopy. The thermal expansion of the tips reaches absolute values of up to 100 nm per mW of emitted laser power. A fully metallized near-field probe tip is shown to serve as a local bolometer with a spatial resolution of better than 1 μm.
Measuring suitability of soybean products for early-weaned pigs with immunological criteria. (1991)

Two trials were conducted to determine the suitability of soybean products for baby pigs. Weanling pigs (n = 40 and 48 in Trials 1 and 2, respectively) were infused orally (6 g/d) with dried skim milk, soybean meal (SBM, 48% CP); soy protein concentrate, moist extruded soy protein concentrate, or soy protein isolate from d 7 to 12 of age. Pigs were then fed a diet containing the same protein source for 1 (Trial 1) or 2 (Trial 2) wk after weaning (d 21 of age). To avoid exposure of pigs to soybean proteins, the dams of pigs were fed a corn-corn gluten meal-based diet supplemented with lysine and tryptophan from d 109 of gestation. All pigs in Trial 1 were killed at 28 d of age, and samples of ileal digesta and small intestine were obtained. In Trial 2, the soy protein isolate was not included, and all pigs were fed a diet containing 4% soybean oil and 1.25% lysine for the last 3 wk of the trial. Growth performance, skin-fold thickness, after intradermal injection of extracts of the corresponding proteins, and anti-soy immunoglobulin G (IgG) titers were measured. Results indicated mat pigs fed diets containing SBM had lower (P < .05) villus height and xylose absorption but higher (P < .05) serum anti-soy IgG titers and increased skin-fold thickness compared with the mean of pigs given milk and all other soy treatments. The presence of residual antigenic protein in the digestive tract of pigs fed SBM indicated mat conventionally processed, commercial SBM may retain some antigens that cause an immunological response in early-weaned pigs. There were no differences in villus height, crypt depth, antibody titers, and skin-fold thickness between soy protein concentrate and moist extruded soy protein concentrate or soy protein isolate. Pigs fed the diet containing moist extruded soy protein concentrate during the first 14 d postweaning had the highest (P < .05) ADG among pigs fed soy protein sources from d 21 to 35 of age. Moist extrusion processing seemed to improve the utilization of soy protein concentrate compared with soybean meal by baby pigs. Performance of pigs fed moist extruded soy protein concentrate was similar to that of pigs fed a dried skim milk-based diet.
Hospitalists: who they are and what they do. (2002)

The hospitalist movement is spreading like wildfire. Find out the latest statistics on hospitalists.
Total synthesis of (.+-.)-byssochlamic acid (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (.+-.)-byssochlamic acidJames D. White, Michael P. Dillon, and Roger J. ButlinCite this: J. Am. Chem. Soc. 1992, 114, 24, 9673–9674Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ja00050a065https://doi.org/10.1021/ja00050a065research-articleACS PublicationsRequest reuse permissionsArticle Views597Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Occurrence of the New Tetracycline Resistance Gene <i>tet</i> (W) in Bacteria from the Human Gut (2000)

Members of our group recently identified a new tetracycline resistance gene, tet(W), in three genera of rumen obligate anaerobes. Here, we show that tet(W) is also present in bacteria isolated from human feces. The tet(W) genes found in human Fusobacterium prausnitzii and Bifidobacterium longum isolates were more than 99.9% identical to those from a rumen isolate of Butyrivibrio fibrisolvens.
Angiogenesis and endothelial cell function. (1994)

Endothelial cell growth is tightly regulated. During embryonic development endothelial cells rapidly proliferate thereby forming new blood vessels. Two different mechanisms contribute to the development of the vascular system: vasculogenesis, the development of blood vessels from in situ differentiating endothelial cells, and angiogenesis, the formation of capillaries from preexisting vessels. In the adult, endothelial cell turnover is very low but under a variety of pathological conditions such as tumor growth these cells quickly enter the cell cycle and divide. Vascular endothelial growth factor (VEGF) has been identified as a key regulatory paracrine growth factor for endothelial cells. Transient VEGF expression correlates with embryonic and tumor angiogenesis. On the other hand, constitutive expression of this factor in choroid plexus and kidney glomerular epithelium and its cognate receptors in adjacent fenestrated endothelium suggests a role for this ligand-receptor system in organotypic endothelial cell differentiation and capillary permeability of fenestrated endothelium.
Microarrays to characterize protein interactions on a whole‐proteome scale (2003)

Protein microarrays contain a defined set of proteins spotted and analyzed at high density, and can be generally classified into two categories; protein profiling arrays and functional protein arrays. Functional protein arrays can be made up of any type of protein, and therefore have a diverse set of useful applications. Advantages of these arrays include low reagent consumption, rapid interpretation of results, and the ability to easily control experimental conditions. The ultimate form of a functional protein array consists of all of the proteins encoded by the genome of an organism; such an array would be the whole proteome equivalent of the whole genome DNA arrays that are now available. While proteome microarrays may not have reached the stage of maturity of DNA microarrays, recent developments have shown that many of the barriers holding back the technology can be overcome. Arrays of this type have already been used to rapidly screen large numbers of proteins simultaneously for biochemical activities, protein-protein interactions, protein-lipid interactions, protein-nucleic acid interactions, and protein-small molecule interactions. Eventually, functional protein arrays will be used to facilitate various steps in the drug discovery and early development processes that are currently bottlenecks in the drug development continuum.
Silurian Bivalvia from Chichagof Island, Southeast Alaska (Alexander terrane) (2011)

Mytilarca boucoti sp. nov. (Ambonychiidae); ?Schizodus sp. A and ?Schizodus sp. B (Schizodidae); Sanguinolites sp. (Sanguinolitidae); ?Modiomorpha sp. and Goniophora thula sp. nov. (Modiomorphinae)].
Aqueous dispersions of TCNQ-anion-stabilized graphene sheets (2008)

Aqueous dispersed graphene was successfully prepared via using 7,7,8,8-tetracyanoquinodimethane (TCNQ) anion as a stabilizer and expanded graphite as a starting material, which could provide a facile route to produce high quality water-soluble and organic solvent-soluble graphene sheets for various applications.