gebhart/patrepeval huggingface dataset:
[Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice]. (2003)

Iron plays a key role in Parkinson s disease (PD). To illustrate the mechanism underlying the increase of iron in substantia nigra (SN) in PD, changes of the expression of divalent metal transporter 1 (DMT1) and iron content were examined in SN in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated mice using immunohistochemistry and histochemistry respectively. Following MPTP treatment for 3 d, elevated iron staining was found in SN. A further increase in iron content was observed after 7 d. In these lesioned animals, tyrosine hydroxylase-immunoreactive DA neurons exhibited a decrease in number and morphological changes as well. There were two isoforms of DMT1 expressed in SN of mice. After MPTP treatment, the expression of DMT1 without IRE form increased in either group, whereas DMT1 with IRE form increased only after 7 d of MPTP treatment. These observations suggest that DMT1 is possibly involved in the process of iron accumulation in SN of MPTP-treated mice, which might be responsible for the subsequent death of DA neurons.
Chain-propagation length of linoleic acid peroxidation in aqueous monomeric and micellar systems (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChain-propagation length of linoleic acid peroxidation in aqueous monomeric and micellar systemsMohammad AlSheikhly and Michael G. SimicCite this: J. Phys. Chem. 1989, 93, 8, 3103–3106Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/j100345a045https://doi.org/10.1021/j100345a045research-articleACS PublicationsRequest reuse permissionsArticle Views121Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Software Process Improvement: Practical Guidelines for Business Success (1998)

This book will help you to manage and control the quality of your organization's software products. Continually dealing with the problems caused by software defects can be both time-consuming and demanding but Sami Zahran's pragmatic approach will take you from reactive fire-fighting to a preventative culture of disciplined and continuous process improvement. This book will help you: establish a process-focused software development organizatio design and implement procedures for developing quality software in time and within budge benchmark your organization against the industry standards for the software process, including the Capability Maturity Model (CMM), ISO 9001, the new standard ISO/IEC 15504 (originally known as SPICE) and Bootstrap.
Self-Diffusion of Lead-210 in Single Crystals of Lead Selenide (1962)

Self-diffusion of Pb-210 in lead selenide has been studied in an inert atmosphere as a function of temperature (over the range 400–800°C) and defect concentration introduced by doping. Diffusion measurements were performed on specimens of p-type PbSe containing 1018 holes per cc and on specimens doped with ½ mole % Bi2Se3 to give n-type material with 5×1019 electrons per cc or ½ mole % Ag2Se which resulted in p-type material containing 1019 holes per cc. Experimental results show that doping with Bi2Se3 decreased diffusivities as compared with undoped PbSe, whereas addition of Ag2Se caused diffusion coefficients to be increased. The diffusion activation energies were 0.83 ev, 1.61 ev, and 0.55 ev for undoped PbSe, bismuth doped PbSe, and silver doped PbSe, respectively. From a consideration of the possible reactions for establishment of equilibrium between solid PbSe and the gas phase, C. Wagner has derived the following equations: [Pb2+ (interstitial)]∝ pPb/[excess electrons]2,[cation vacancy]∝[excess electrons]2/pPb,where the value of pPb is to be treated as a constant under the conditions of this experiment. From a consideration of the point defects introduced by doping and an evaluation of diffusion data applied to the above equations, it is concluded that Frenkel defects predominate in lead selenide and that diffusion of lead in this compound occurs predominantly by an interstitial mechanism under these conditions.
Color Science and Digital Color Reproduction: Delivering on the Promise (2004)

The reproduction of color as practiced in the graphic arts, professional and consumer photography has undergone a remarkable transformation in the past decade and a half. What was once very much a craft, skill, and art has become a computational process supported by the disciplines of color science, image science, image processing, signal processing, and computer science. The search for a solution to the communication of color information in distributed computer systems that received much attention dating from early efforts at standardization; e.g. Office Document Architecture (ODA) has led to a fundamental shift in the measurement basis for color information in digital color reproduction systems. The colorimetric specification of color replaced, in large measure, the device-dependent representations that were based upon sensitometry. This enabled much of the science of human vision to be brought to bear in a computational manner in the process of color reproduction. This has placed new demands on the science of color measurement and the related color spaces which have evolved under the auspices of the CIE. The computational potential of this representation has already produced significant changes in both capture and output devices.Digital cameras may now contain complex internal pipelines offering a range of processes such as chromatic adaptation computation, color space conversions, and algorithms based on the adaptive processes of the human visual system. Digital printers may have equally complex image processing pipelines. To make this complexity accessible to the user an architectural solution is being sought in the form of color management (International Color Consortium, ICC). The result has been that many of the processes executed by skilled operators have become menu choices or automatic operations that are computationally executed. Much progress has been made in turning color reproduction into a systematic process, but the question remains: How far can this be taken? Much stress has been placed upon colorimetry to provide the foundation for this approach to color reproduction. This keynote will examine what challenges lie ahead for color science and contrast them with the expectations that have emerged in the consumer and professional marketplaces. The subjective nature of color reproduction must be accommodated at the same time as taking full advantage of the objective processes that can simplify and streamline the generation of high-quality color output. What is the role of color science research in realizing this goal? This paper will also offer suggestions as to the logical placement and access for the artistic skills of the professional practitioner in photography and the graphic arts.
A Descriptive Study to Assess the Knowledge and Attitude regarding the Play Needs of Toddlers among Parents in a Selected Hospital of New Delhi (2018)

Introduction: Since ages, play is considered to be an essential aspect for a child's overall development including physical, cognitive, emotional and social development. The play needs of a child keep changing with the different stages of growth and development. For a healthy development of the child, it is important to assess and acknowledge the different play needs of children at different stages. Definitely, there can be no one better than the parents who can understand the play needs and facilitate them accordingly. Hence a need was felt to conduct a study to assess the knowledge and attitude regarding the play needs of toddlers among parents. The objectives of this study were to assess the knowledge and attitude regarding the play needs of toddlers among parents in a selected hospital of New Delhi.
Identification of Vitronectin as a Novel Insulin-Like Growth Factor-II Binding Protein (1999)

We have previously reported the presence of a 70 kDa insulin-like growth factor (IGF)-II-specific binding protein in chicken serum using Western ligand blotting approaches. In order to ascertain the identity of this 70 kDa IGF-II binding species, the protein has been purified from chicken serum using a combination of ion-exchange and gel-permeation chromatography. Interestingly, amino acid sequencing of the purified protein revealed that it has the same N-terminal sequence as chicken vitronectin (VN). The protein has the ability to specifically bind IGF-II and not IGF-I as determined by ligand blotting, cross-linking and competitive binding assay approaches. In addition, the protein binds 125I-des(1-6)-IGF-II, suggesting that the interaction with IGF-II is different to those with other characterized IGF-binding proteins. Importantly, we have ascertained that both human and bovine VN also specifically bind IGF-II. These results are particularly relevant in the light of the recent report that the urokinase-type plasminogen activator receptor, a protein that also binds VN, has been shown to associate with the cation-independent mannose-6-phosphate/IGF-II receptor and suggest a possible role for IGF-II in cell adhesion and invasion.
Preclinical Evidence for the Pharmacological Actions of Naringin: A Review (2014)

Naringin, chemically 4',5,7- trihydroxyflavanone-7-rhamnoglucoside, is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. It has been experimentally documented to possess numerous biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. In vitro and in vivo studies have further established the usefulness of naringin in various preclinical models of atherosclerosis, cardiovascular disorders, diabetes mellitus, neurodegenerative disorders, osteoporosis, and rheumatological disorders. Apart from this, naringin has also exerted chemopreventive and anticancer attributes in various models of oral, breast, colon, liver, lung, and ovarian cancer. This wide spectrum of biological expediency has been documented to be a result of either the upregulation of various cell survival proteins or the inhibition of inflammatory processes, or a combination of both. Due to the scarcity of human studies on naringin, this review focuses on the various established activities of naringin in in vitro and in vivo preclinical models, and its potential therapeutic applications using the available knowledge in the literature. Additionally, it also encompasses the pharmacokinetic properties of naringin and its inhibition of CYP isoenzymes, and the subsequent drug interactions. Moreover, further clinical research is evidently needed to provide significant insights into the mechanisms underlying the effects of naringin in humans.
Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs (2013)

We established a colorectal cancer stem cell line P6C with a high tumorigenic capacity and the characteristics of normal stem cells. It will benefit the mechanistic studies on cancer stem cells and the development of drugs that specifically target the cancer stem cells.
The wave kernel signature: A quantum mechanical approach to shape analysis (2011)

We introduce the Wave Kernel Signature (WKS) for characterizing points on non-rigid three-dimensional shapes. The WKS represents the average probability of measuring a quantum mechanical particle at a specific location. By letting vary the energy of the particle, the WKS encodes and separates information from various different Laplace eigenfrequencies. This clear scale separation makes the WKS well suited for a large variety of applications. Both theoretically and in quantitative experiments we demonstrate that the WKS is substantially more discriminative and therefore allows for better feature matching than the commonly used Heat Kernel Signature (HKS). As an application of the WKS in shape analysis we show results on shape matching.
Two-Phase Dynamic Modeling of PEMFCs and Simulation of Cyclo-Voltammograms (2005)

A mathematical model is developed that is based on a coupled system of partial differential equations. The model contains a dynamic and two-phase description of the proton exchange membrane fuel cell (PEMFC) and a membrane model that accounts for Schroeder's paradox. The mass transport in the gas phase and in the liquid phase is considered as well as the phase transition between liquid water and water vapor. The transport of charges and the electrochemical reactions are part of the model. A potential sweep experiment is simulated using the mathematical model and measured using a test cell with an active area of 1 cm(2). In this way, the dynamic effect of liquid water formation and transport on the current-voltage characteristic of the fuel cell is investigated. A hysteresis effect is found in the measured time-dependent current-voltage relation. The limiting current density is time-dependent. Qualitative agreement of simulated and measured results is achieved. An analysis of the observed hysteresis of the current-voltage characteristics, based on the modeling results, is given. (c) 2005 The Electrochemical Society.
The Pain Drawing and Waddellʼs Nonorganic Physical Signs in Chronic Low-Back Pain (1993)

Pain drawings were obtained from a group of 651 patients who had chronic low-back pain. Pain drawings were rated in four grades according to the degree of organic and nonorganic pain. Experienced and inexperienced evaluators were used. The reliability was excellent with an interevaluator reliability between 73% and 78%. A correlation between pain drawings and Waddell's nonorganic physical signs demonstrated that a large proportion of patients with high Waddell scores had nonorganic pain drawings. No significant differences were noted in the distribution of Waddell scores and pain drawings based on patient gender or payment status (i.e., medicolegal or workers' compensation). Pain drawings afford an important adjunct in the physician's assessment of chronic low-back pain.
Survival Capacity of Haploid‐Diploid Goldfish Chimeras (2004)

In teleosts, haploidy has been considered to be inviable due to the expression of abnormalities during embryogenesis, but the recent report of live haploid-diploid mosaic fish suggests the probable improvement of survival capacity by adding diploid cells or tissues to haploid embryos. In order to examine such possibilities, two types of haploid-diploid goldfish chimeric embryos were produced by transplantation of blastoderm between the normally fertilized diploid and the artificially induced gynogenetic haploid: the haploid-base chimera with the diploid upper half on the haploid lower half blastoderm and the diploid-base chimera with the haploid upper half on the diploid lower half blastoderm. Fluorescent detection of FITC-labeled cells, subsequent histochemical detection of biotin-labeled haploid cells and flow-cytometrical detection of both haploid and diploid cells proved successful induction of the haploid-diploid chimera. Both types of chimeric embryos demonstrated much better survival capacity than pure haploid individuals, but all the haploid-base chimeras died before 10 days after fertilization due to the expression of edema, whereas several diploid-base chimeras survived until 16 months after fertilization when the experiment was ended. This concluded diploid-base chimeras became viable by adding diploid cells to haploid embryos. However, the proportion of transplanted haploid cells was reduced and the distribution of these cells was limited to certain organs because survivors exhibited haploid cells only in brain, eye and/or skin. These results suggest possible elimination of haploid cells from the organs originated from ectoderm.
Synthesis of Highly Symmetrical Triptycene Tetra- and Hexacarboxylates (2007)

Two alternative procedures, both starting from easily accessible­ tetramethylanthracenes and employing the Diels-Alder addition as the key reaction step(s), have been examined in the synthesis of the title compounds.
Synthesis, Preclinical Validation, Dosimetry, and Toxicity of <sup>68</sup>Ga-NOTA-Anti-HER2 Nanobodies for iPET Imaging of HER2 Receptor Expression in Cancer (2013)

A new anti-HER2 PET tracer, (68)Ga-NOTA-2Rs15d, was synthesized via a rapid procedure under mild conditions. Preclinical validation showed high-specific-contrast imaging of HER2-positive tumors with no observed toxicity. (68)Ga-NOTA-2Rs15d is ready for first-in-human clinical trials.
Frequency Synchronization Algorithm for Improving Performance of OFDMA System in 3GPP LTE Downlink (2009)

In this paper, we propose a receiver structure for frequency synchronization in OFDMA (Orthogonal Frequency Division Multiple Access) system which is considered as 3GPP LTE(Long Term Evolution) downlink. In general, OFDMA frequency synchronization consists of two parts: coarse synchronization and fine synchronization. We consider P-SCH (Primary-Synchronization Channel) and CP (Cyclic Prefix) of OFDMA symbol for coarse synchronization and fine synchronization, respectively. The P-SCH signal has two remarkable disadvantages that it does not have sufficiently many sub-carriers and its differential correlation characteristic is not good due to ZC (Zadoff Chu) sequence-specific property. Hence, conventional frequency synchronization algorithms cannot obtain satisfactory performance gain. In this paper, we propose a modified differential correlation algorithm to improve performance of the coarse frequency synchronization. Also, we introduce an effective PLL (Phase Locked Loop) structure to guarantee stable performance of the fine frequency synchronization. Simulation results verify that the proposed algorithm has superior performance to the conventional algorithms and the 2nd-order PLL is effective to track the fine frequency offset even in high mobility.
Color signal decomposition method using 3-D Gamut boundary of multi-primary display (2005)

Color signal decomposition method is to decompose the conventional three-primary colors (RGB) into the multi-primary control values of multi-primary display (MPD) under the constraints of tri-stimulus matching. For the satisfaction of tri-stimulus matching between input and output display systems, the MPD color signals have to be estimated from a device-independent color space such as CIEXYZ or CIELAB. However, as the target of MPD is to display moving-picture data, it is necessary to simplify the color space conversion between input and output systems and decomposition of the multi-primary control values. In this paper, color signal decomposition method for MPD is proposed using 3-dimensional look-up-table (3D-LUT) in linearized LAB space. The linearized LAB space satisfies the linearity and additivity in color space conversion and easily constructs the 3-D LUT considering lightness, chroma, and hue. For the reproduction of moving-picture data in MPD, the proposed method is based on 3-D LUT structure to reduce the complexity of hardware and processing time. First, 3-D LUT containing gamut boundary data of MPD is created to derive the multi-primary control values. The input images are transformed to linearized LAB values. Then, the corresponding color signals on the gamut boundary points, which have the same lightness and hue as the input point, are calculated. Also, the color signal for a point on the gray axis is calculated. Based on the gamut boundary points and a point on the gray axis, the MPD color signals for the input values can be obtained by interpolating between the gamut boundary points and a point on the gray axis. In particular, the neighboring gamut boundary points are used in the region of occurring abrupt signal change for a smooth change of hue. As a result, the proposed method guarantees computational efficiency and color signal continuity and requires less memory rather than conventional color decomposition methods.
Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization (2003)

Pigment epithelium-derived factor (PEDF) inhibits the formation of blood vessels in the eye by inducing apotosis in actively dividing endothelial cells. The activity of PEDF equals or supersedes that of other anti-angiogenic factors, including angiostatin, endostatin and thrombospondin-1. In addition, PEDF has the potential to promote the survival of neurons and affect their differentiation. Here we show that PEDF is present in plasma at a concentration of approx. 100 nM (5 microg/ml) or twice the level required to inhibit aberrant blood-vessel growth in the eye. Thus the systemic delivery of PEDF has the potential to affect angiogenesis or neurotrophic processes throughout the body, significantly expanding the putative physiological role of the protein. A complete map of all post-translational modifications revealed that authentic plasma PEDF carries an N-terminal pyroglutamate blocking group and an N-linked glycan at position Asn266. The pyroglutamate residue may regulate the activity of PEDF analogously to the manner in which it regulates thyrotropin-releasing hormone.
The Electrochemical Properties of the Porous Nafion Membrane for Proton Exchange Membrane Fuel Cells (PEMFCs) (2012)

E-mail: cheolwoo@sungshin.ac.krReceived December 27, 2011, Accepted February 15, 2012Key Words : Nafion membrane, Porous membrane, Proton conductivity, Polymer electrolyte membrane, Va-por pressure of waterProton exchange membrane fuel cells (PEMFCs) havebeen paid a great attention as a clean power generator toconvert the chemical energy of hydrogen to electric energyand they have major advantages, such as the high powerdensity and energy efficiency, rapid start-up, etc., for theportable electronic devices and transportation/stationarypower systems.
Nonlinear Analysis of RC Members Using Plasticity with Multiple Failure Criteria (1997)

Concrete plasticity models for the analysis of reinforced-concrete (RC) members in plane stress are studied. The proposed plasticity model for reinforced concrete provides a unified approach combining plasticity theory and damage models. It addresses strength enhancement under multiaxial compression, and tensile cracking damage. The model uses multiple failure criteria for compressive crushing and tensile cracking. For tensile cracking behavior, rotating-crack and fixed-crack plasticity models are compared. As crushing failure criterion, the Drucker-Prager and von Mises models are used for comparison. The proposed model uses new and existing damage models for tension softening, tension stiffening, and compression softening due to tensile cracking. Finite-element analyses using the plasticity model are compared with existing experimental results. To verify the proposed crushing and cracking plasticity models, the experiments have load capacities governed either by compressive crushing of concrete or by yielding of reinforcing steel. The advantages and disadvantages of rotating-crack and fixed-crack plasticity models are discussed.