gebhart/patrepeval huggingface dataset:
On digital spectrum analysis of periodic signals (1975)

Digital spectrum analysis of harmonic signals can result in amplitude estimates in error as much as 3.92 dB. The corresponding frequency estimates are not exact. The paper presents a general method for obtaining significantly improved estimates of amplitude and frequency. Criteria are given which allow specification of an error limit. Specific equations are given for sample signals that are unmodified (open window) and for signals modified by a Hanning data window. The phenomenon called ’’leakage’’ is shown to result from discontinuities imposed by the computation process at the periodically extended ’’ends’’ of a sample signal and not, as is often supposed, by discontinuities presumed to (but do not) exist at the ’’ends’’ of the open window. Criteria for window selection to reduce leakage are discussed. Calibration is specifically treated. When any data window other than the open window is used, a different calibration must be applied to periodic and random components in a signal. Although discussion is limited to a single harmonic signal, the method can be applied in a straightforward way to signals with multiple harmonics. Subject Classification: 10.60; 60.10; 30.80; 40.60; 50.85, 60.50; 85.32, 85.84.
Glycosylation of the overlapping sequons in yeast external invertase: effect of amino acid variation on site selectivity in vivo and in vitro (1999)

Yeast invertase contains 14 sequons, all of which are glycosylated to varying degrees except for sequon 5 which is marginally glycosylated, if at all. This sequon overlaps with sequon 4 in a sequence consisting of Asn92-Asn93-Thr94-Ser95(Reddy et al., 1988, J. Biol. Chem., 263, 6978-6985). To determine whether glycosylation at Asn93is sterically hindered by the oligosaccharide on Asn92, the latter amino acid was converted to a glutamine residue by site-directed mutagenesis of the SUC2 gene in a plasmid vector which was expressed in Saccharomyces cerevisiae. A glycopeptide encompassing sequons 3 through 6 was purified from a tryptic digest of the mutagenized invertase and sequenced by Edman degradation, which revealed that Asn93 of sequon 5 contained very little, if any, carbohydrate, despite the elimination of sequon 4. When Ser and Thr were inverted to yield Asn-Asn-Ser-Thr carbohydrate was associated primarily with the second sequon, in agreement with numerous studies indicating that Asn-X-Thr is preferred to Asn-X-Ser as an oligosaccharide acceptor. However, when the invertase overlapping sequons were converted to Asn-Asn-Ser-Ser, both sequons were clearly glycosylated, with the latter sequon predominating. These findings rule out steric hindrance as a factor involved in preventing the glycosylation of sequon 5 in invertase. Comparable results were obtained using an in vitro system with sequon-containing tri- and tetrapeptides acceptors, in addition to larger oligosaccharide acceptors.
Vaccines and Therapeutics for the Encephalitic Alphaviruses (2013)

This article is a review of vaccines and therapeutics in development for the encephalitic alphaviruses, which includes eastern equine encephalitis virus, western equine encephalitis virus and Venezuelan equine encephalitis virus. The encephalitic alphaviruses are endemic within regions in North and South America. Hosts are normally exposed after being bitten by infectious mosquitoes, and infection can develop into encephalitis in equines and humans with severe rates of morbidity and mortality. These viruses are also potential biological threat agents, being highly infectious via an aerosol route of exposure. In humans, equine encephalitis virus and western equine encephalitis virus are neurotropic viruses targeting the CNS and causing encephalitis. Mortality rates are 50 and 10%, respectively, for these viruses. On the other hand, Venezuelan equine encephalitis virus produces a systemic influenza-like illness with pathogenesis in the lungs and lymphoid tissue in adults and older children. The incidence of encephalitis is less than 5% in younger children with a case–mortality rate of 1%. The host response to virus infectivity is briefly discussed, along with a number of promising therapeutic and prophylactic approaches. These approaches can be broadly classified as: virus-specific, including vaccines, antibody therapy and gene-silencing oligonucleotides; or broad-spectrum, including interferon and activation of the host‘s innate immunity.
Aspectos procesales referentes a la impugnación y valoración de la prueba pericial en el proceso civil (2010)

En el presente trabajo se examinan, dentro del sistema de la prueba pericial en el ambito del proceso civil, el alcance y efectos de la no impugnacion del informe pericial en la fase de la audiencia previa. A continuacion se estudian las consecuencias de la coexistencia y confrontacion de la pericia judicial versus la pericia de parte. Otra de las cuestiones que se tratan se refiere a la posibilidad o no de solicitar las partes, de mutuo acuerdo, un dictamen pericial dirimente; y, por ultimo, se analiza la revision de la prueba pericial en la segunda instancia.
Truncation artifact reduction in transmission CT for improved SPECT attenuation compensation. (1995)

Transmission computed tomography (TCT) has been shown to be an accurate method of acquiring non-uniform attenuation maps for single-photon emission computed tomography (SPECT) attenuation compensation. One commonly encountered problem, especially for convergent beam geometries, is image truncation. We describe two methods for reducing associated truncation artifacts, with the goal of improving SPECT attenuation compensation without unduly increasing imaging or reconstruction times: (i) the two-scan method, which reduces the degree of truncation by combining two short-duration, patient-shifted scans, and (ii) a quantitative extrapolation method, which fills in truncated projections accounting for the correct amount of attenuating medium in the slice. The methods are evaluated by imaging two phantoms on a fan beam TCT system. Projection sets are truncated to various degrees with software, and reconstructed images are compared to both untruncated filtered backprojection and iterative reconstructions of truncated data. A fundamental analysis of SPECT attenuation factors is performed, and attenuation compensation of a cardiac insert is analysed. Results indicate the two-scan method can effectively reduce the degree of truncation in many cases, and the quantitative extrapolation method greatly improves SPECT attenuation compensation over using truncated maps.
Dechema Monographien. Band 6 (1935)

ADVERTISEMENT RETURN TO ISSUEPREVBook and Media Revie...Book and Media ReviewDechema Monographien. Band 6W. T. Read Cite this: J. Chem. Educ. 1935, 12, 4, 200Publication Date (Print):April 1, 1935Publication History Received3 August 2009Published online1 April 1935Published inissue 1 April 1935https://doi.org/10.1021/ed012p200.3RIGHTS & PERMISSIONSArticle Views90Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
The latency hiding effectiveness of decoupled access/execute processors (2002)

Several studies have demonstrated that out-of-order execution processors may not be the most adequate organization for wide-issue processors due to the increasing penalties that wire delays cause in the issue logic. The main target of out-of-order execution is to hide functional unit latencies and memory latency. However, the former can be quite effectively handled at compile time and this observation is one of the main arguments for the emerging EPIC architectures. In this paper, we demonstrate that a decoupled access/execute organization is very effective at hiding memory latency, even when it is very long. This paper presents a thorough evaluation of such processor organization. First, a generic decoupled access/execute architecture is defined and evaluated. Then the benefits of a lockup-free cache, control speculation and a store-load bypass mechanism under such an architecture are evaluated. Our analysis indicates that memory latency can be almost completely hidden by such techniques.
Mutual authentication protocols for the virtual home environment in 3G mobile network (2004)

In the virtual home environment (VHE), which was proposed to offer global roaming and personal service environment portability, user's profiles and service logic are conveyed from home network to visited network to provide services at the visited network. Because user's profiles and service logics may contain confidential information, some procedures for mutual authentication among entities for offering confidence are needed. For these issues, we propose and analyze two 3-party mutual authentication protocols adaptable to the VHE in 3G; the password based mutual authentication protocol and the mutual authentication protocol with trusted third party.
Structural and mechanistic analysis of two prolyl endopeptidases: Role of interdomain dynamics in catalysis and specificity (2005)

Prolyl endopeptidases (PEPs) are a unique class of serine proteases with considerable therapeutic potential for the treatment of celiac sprue. The crystal structures of two didomain PEPs have been solved in alternative configurations, thereby providing insights into the mode of action of these enzymes. The structure of the Sphingomonas capsulata PEP, solved and refined to 1.8-A resolution, revealed an open configuration of the active site. In contrast, the inhibitor-bound PEP from Myxococcus xanthus was crystallized (1.5-A resolution) in a closed form. Comparative analysis of the two structures highlights a critical role for the domain interface in regulating interdomain dynamics and substrate specificity. Structure-based mutagenesis of the M. xanthus PEP confirms an important role for several interfacial residues. A salt bridge between Arg-572 and Asp-196/Glu-197 appears to act as a latch for opening or closing the didomain enzyme, and Arg-572 and Ile-575 may also help secure the incoming peptide substrate to the open form of the enzyme. Arg-618 and Asp-145 are responsible for anchoring the invariant proline residue in the active site of this postproline-cleaving enzyme. A model is proposed for the docking of a representative substrate PQPQLPYPQPQLP in the active site, where the N-terminal substrate residues interact extensively with the catalytic domain, and the C-terminal residues stretch into the propeller domain. Given the promise of the M. xanthus PEP as an oral therapeutic enzyme for treating celiac sprue, our results provide a strong foundation for further optimization of the PEP's clinically useful features.
Flash analog-to-digital converter using resonant-tunneling multiple-valued circuits (2002)

We have proposed a flash analog-to-digital converter (ADC) that uses resonant-tunneling complex gates not only as ternary quantizers but also as ternary-to-binary encoder circuits. The ternary quantizers, consisting of monostable-to-multistable transition logic (MML) circuits, convert the analog input signal into the ternary thermometer code. This code is then converted into the binary Gray-code output by a multiple-valued, multiple-input monostable-to-bistable transition logic element (M/sup 2/-MOBILE). By assuming InP-based resonant-tunneling diodes and heterojunction field-effect transistors, we have carried out SPICE simulation that demonstrates ultrahigh-speed ADC operation at a clock frequency of 5 GHz. Compact circuit configuration, which is due to the combination of MML and M/sup 2/-MOBILE, reduces the device count and power dissipation by a factor of two compared with previous RTD-based ADCs.
Public health issues arising from microbiological and labelling quality of foods and supplements containing probiotic microorganisms (1999)

Our findings have public health implications, and suggest that improvements are needed in labelling and quality assurance procedures for products containing probiotic organisms. The presence of the potential pathogen Enterococcus faecium (intentionally or as a contaminant) in some products calls for a review of the value of this species as a probiotic.
Fiber Optics Sensing Systems for Subsea Applications–Sensing Capabilities, Applications, and the Challenges Being Faced in Order to Provide Reliable Transmission of Data for OnLine Reservoir Management (2008)

Abstract The industry has seen the gradual implementation of step-change optical sensing technology as one way to address the issue of reliable permanent downhole gauges. This paper will include case histories that indicate an ever-broadening acceptance of this technology with application scenarios ranging from simple single-gauge installations to multi-zone intelligent wells with integrated sensing and remotely activated in-well zonal flow control - true Smart or Intelligent Wells, with now over 600 installations worldwide. Present measurement capabilities include Pressure and Temperature, Distributed Temperature Sensing (DTS), Single- and Multiphase Flowmeters, Seismic Accelerometers and hydrophones, and the paper will also detail additional downhole and subsea optical sensing systems currently under development. As subsea continues to play a vital role in our industry, it has been recognized that there are a number of challenges to be addressed before optical sensing systems will be widely adopted subsea. These challenges are being addressed in part by a new thirty member company industry group, SEAFOM (Subsea FiberOptic Monitoring) – this group's activities will be described. In addition, a number of operating and service companies have on-going related initiatives. For example, StatoilHydro has an Integrated Operations (IO) initiative aimed at significantly increasing overall recovery rates of subsea production assets. As part of that initiative, StatoilHydro and Weatherford signed a three year Technical Development Cooperation Agreement in June 2006. This project will make real-time reservoir monitoring and downhole data available everywhere on a StatoilHydro network infrastructure. This paper includes the rationale for selecting fiber optics as the baseline technology and also describes the technical solution for an open, high speed communication infrastructure. The project is also developing interfaces towards existing subsea systems with only electrical, low bandwidth communication systems. Solutions are being developed for both Green and retrofit Brown field applications.
Packaging of large-scale planar lightwave circuits (2002)

This paper describes the packaging of large-scale silica-based planar lightwave circuits (PLCs), fabricated on Si substrates. They include arrayed-waveguide grating (AWG) multiplexers and star couplers with more than 32 channels, and optical matrix switches with a scale of 8/spl times/8 or greater. These devices all have a large channel-number or a large number of switch elements. There are various technological objectives and techniques related to large-scale PLCs which concern their optical, electrical, thermal, and mechanical characteristics. Several techniques are presented in detail based on experimental results.
Composite Damping of Vibrating Sandwich Beams (1967)

Research Papers Composite Damping of Vibrating Sandwich Beams R. A. DiTaranto, R. A. DiTaranto PMC Colleges, Chester, Pa. Search for other works by this author on: This Site PubMed Google Scholar W. Blasingame W. Blasingame U. S. Navy Marine Engineering Laboratory, Annapolis, Md. Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information R. A. DiTaranto PMC Colleges, Chester, Pa. W. Blasingame U. S. Navy Marine Engineering Laboratory, Annapolis, Md. J. Eng. Ind. Nov 1967, 89(4): 633-638 https://doi.org/10.1115/1.3610124 Published Online: November 1, 1967 Article history Received: December 1, 1966 Online: August 25, 2011
Relative scheduling under timing constraints (1990)

Scheduling techniques are used in high-level synthesis of integrated circuits. Traditional scheduling techniques assume fixed execution delays for the operations. For the synthesis of ASIC designs that interface with external signals and events, operations with unbounded delays, i.e. delays unknown at compile time, must also be considered. We present a relative scheduling technique that supports operations with fixed and unbounded delays. The technique satisfies the timing constraints imposed by the user, which places bounds between the activation of operations. We analyze a novel property called well-posedness of timing constraints that is used to identify consistency of constraints in the presence of unbounded delay operations, and present an approach to relative scheduling that yields a minimum schedule that satisfies the constraints, or detects if no schedule exists, in polynomial time.
Human brain dopamine receptors in children and aging adults (1987)

Since spontaneous oral dyskinesias are more prevalent in the elderly, and since these movements may be controlled by the balance of brain dopamine D1 and D2 dopamine receptors, we measured the densities of these receptors in 247 postmortem brain striata. In childhood, the densities of D1 and D2 dopamine receptors in the brain striatum rise and fall together. After age 20 years, D1 receptors disappear at 3.2% per decade while D2 receptors disappear at about 2.2% per decade. Overall, therefore, the D1/D2 ratio falls with age. Since perioral motion in rats is dominated by a high D1/D2 ratio, the observed decline in the human D1/D2 ratio with age suggests that the perioral control mechanisms for humans and rats may be different.
<i>Turbulence: The Legacy of A. N. Kolmogorov</i> (1996)

Share Icon Share Twitter Facebook Reddit LinkedIn Reprints and Permissions Cite Icon Cite Search Site Citation Uriel Frisch, Russell J. Donnelly; Turbulence: The Legacy of A. N. Kolmogorov. Physics Today 1 November 1996; 49 (11): 82–84. https://doi.org/10.1063/1.881555 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPhysics Today Search Advanced Search
Quantitative analysis of hydrogen in thin film by scattering-recoil co-measurement technique (2006)

Hydrogen analysis by elastic recoil detection has been performed utilizing polyimide film as a reference sample of known hydrogen content assuming the soundness of ion beam current integration. However beam current integration at higher incidence angle is not reliable. Scattering yield per unit fluence by current integration which is normalized per unit path length decreases as the sample tilt angle is getting higher. Moreover because beam current integration at high tilt angle is incomplete, hydrogen evaluation is very risky by direct comparison of sequentially collected recoil spectra between reference and target sample. In this study, primary ion beam dose is determined by backscattering spectrum that is collected simultaneously with recoil spectrum instead of ion beam current integration in order to reduce uncertainty arising in the process of current integration and to enhance the reliability of quantitative analysis. Three test samples are selected polyimide film, hydrogen implanted silicondioxide and Au deposited carbon wafer- and analyzed by two methods and compared.
A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection (1998)

Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy.
Six-month overnight intraperitoneal amino-acid infusion in continuous ambulatory peritoneal dialysis (CAPD) patients--no effect on nutritional status. (1990)

The long-term effect of an AA solution based on Travasol, a solution for total parenteral nutrition, given intraperitoneally over a 6-month period was studied in 5 patients 22 to 75 years old, having been on continuous ambulatory peritoneal dialysis (CAPD) for 3 to 57 months. A low oral protein intake (less than 0.8 g/kg bw/day) and/or a low serum albumin (less than 35 g/L) were used as inclusion criteria. Two liters of 1% AA solution were infused overnight, while a glucose Dianeal was used for the other exchanges. During the study, BUN increased from 22.04 mM/L to 28.06 mM/L the first month and remained at these levels, indicating the increased protein intake. However, average oral total energy and protein intake, body weight (bw), serum creatinine, cholesterol, triglycerides, total proteins, albumin, transferrin, skinfold thickness, total body potassium, and plasma AA levels remained basically unchanged. The average total body nitrogen decreased from 1.746 to 1.554 Kg, but this decrease did not reach statistical significance (p greater than 0.05). We conclude that intraperitoneal overnight administration of 2 L of 1% AA based on Travasol over 6 months did not improve the nutritional status of CAPD patients. This ineffectiveness might be due to the AA composition of the solution, the timing of administration, or to a low caloric intake and/or that our patients were not severely malnourished.
[Establishment of high-throughput drug screening cell models based on JAK-STAT signal pathway]. (2004)

The method can be performed by high-throughput drug screening for effective extraction of Chinese traditional herbs.
Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics (2009)

Perfluorocarbon (PFC) emulsions are halogen-substituted carbon nonpolar oils with resultant enhanced dissolved respiratory gas (O(2), N(2), CO(2), nitric oxide) capabilities. In the first demonstration of enhanced O(2) solubility, inhaled PFC could sustain rat metabolism. Intravenous emulsions were then trialed as "blood substitutes." In the last 10 yr, biocomputational modeling has enhanced our mechanistic understanding of PFCs. Contemporary research is now taking advantage of these physiological discoveries and applying PFCs as "oxygen therapeutics," as well as ways to enhance other gas movements. One particularly promising area of research is the treatment of gas embolism (arterial and venous emboli/decompression sickness). An expansive understanding of PFC-enhanced diffusive gas movements through tissue and vasculature may have analogous applications for O(2) or other respiratory gases and should provide a revolution in medicine. This review will stress the fundamental knowledge we now have regarding how respiratory gas movements are changed when intravenous PFC is present.