gebhart/patrepeval huggingface dataset:
Prediction of Hidden Liquidity in theLimit Order Book of GLOBEX Futures (2013)

At the center of the CME’s GLOBEX system—the leading Western derivatives exchange by volume traded—is the limit order book. A key trait of the GLOBEX limit order book is how displayed volume does not necessarily represent the true volume, due to the existence of hidden volume. One such type of hidden volume is the iceberg order, where the participant can choose not to display the true order size (so as to reduce market impact). Iceberg orders are often significantly larger than the average order size, making them of particular interest to market makers, as order book volume is a key determinant of supply and demand. This article’s main contribution is a GLOBEX-specific, iceberg order prediction algorithm that sits on the exchange feed handler and is implementable with millisecond latency. By modeling market microstructure using limit order book data, the algorithm detects iceberg orders and predicts their remaining hidden volume. The algorithm is applied to data from the e-mini S&P 500 future from the year 2011. It is estimated that 9% of the volume in the limit order book for this future is composed of iceberg orders. A potential application of this algorithm would be allowing market makers to pick off iceberg orders, increasing their traded volume. <b>TOPICS:</b>Derivatives, exchanges/markets/clearinghouses, quantitative methods
Sobolev GAN (2017)

We propose a new Integral Probability Metric (IPM) between distributions: the Sobolev IPM. The Sobolev IPM compares the mean discrepancy of two distributions for functions (critic) restricted to a Sobolev ball defined with respect to a dominant measure $\mu$. We show that the Sobolev IPM compares two distributions in high dimensions based on weighted conditional Cumulative Distribution Functions (CDF) of each coordinate on a leave one out basis. The Dominant measure $\mu$ plays a crucial role as it defines the support on which conditional CDFs are compared. Sobolev IPM can be seen as an extension of the one dimensional Von-Mises Cram\'er statistics to high dimensional distributions. We show how Sobolev IPM can be used to train Generative Adversarial Networks (GANs). We then exploit the intrinsic conditioning implied by Sobolev IPM in text generation. Finally we show that a variant of Sobolev GAN achieves competitive results in semi-supervised learning on CIFAR-10, thanks to the smoothness enforced on the critic by Sobolev GAN which relates to Laplacian regularization.
[Development of a method for the immunological measurement of aspartate aminotransferase with monoclonal antibodies]. (2003)

We have developed a new immunological assay using generated monoclonal antibodies to human cytosolic AST and used them for the development of a fluorescent assay measuring the enzyme mass. Cytosolic AST mass in sera could be measured reproducibly by the immunological method. In conclusion, this study has provided us with a new type of tool for an accurate measurement of the enzyme amount in circulation.
Structure−Activity Relationships in Peptide Modulators of β-Amyloid Protein Aggregation: Variation in α,α-Disubstitution Results in Altered Aggregate Size and Morphology (2010)

Neuronal cytotoxicity observed in Alzheimer's disease (AD) is linked to the aggregation of β-amyloid peptide (Aβ) into toxic forms. Increasing evidence points to oligomeric materials as the neurotoxic species, not Aβ fibrils; disruption or inhibition of Aβ self-assembly into oligomeric or fibrillar forms remains a viable therapeutic strategy to reduce Aβ neurotoxicity. We describe the synthesis and characterization of amyloid aggregation mitigating peptides (AAMPs) whose structure is based on the Aβ "hydrophobic core" Aβ(17-20), with α,α-disubstituted amino acids (ααAAs) added into this core as potential disrupting agents of fibril self-assembly. The number, positional distribution, and side-chain functionality of ααAAs incorporated into the AAMP sequence were found to influence the resultant aggregate morphology as indicated by ex situ experiments using atomic force microscopy (AFM) and transmission electron microscopy (TEM). For instance, AAMP-5, incorporating a sterically hindered ααAA with a diisobutyl side chain in the core sequence, disrupted Aβ(1-40) fibril formation. However, AAMP-6, with a less sterically hindered ααAA with a dipropyl side chain, altered fibril morphology, producing shorter and larger sized fibrils (compared with those of Aβ(1-40)). Remarkably, ααAA-AAMPs caused disassembly of existing Aβ fibrils to produce either spherical aggregates or protofibrillar structures, suggesting the existence of equilibrium between fibrils and prefibrillar structures.
Microwave Measurement of Electron Density in a Penning Discharge (1970)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation W. J. Lange; Microwave Measurement of Electron Density in a Penning Discharge. J. Vac. Sci. Technol. 1 January 1970; 7 (1): 228–232. https://doi.org/10.1116/1.1315803 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science and Technology Search Advanced Search |Citation Search
Hans Kurath, Studies in area linguistics. Bloomington and London: Indiana University Press, 1972. Pp. 202. (1974)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
DNA Solution of the Maximal Clique Problem (1997)

The maximal clique problem has been solved by means of molecular biology techniques. A pool of DNA molecules corresponding to the total ensemble of six-vertex cliques was built, followed by a series of selection processes. The algorithm is highly parallel and has satisfactory fidelity. This work represents further evidence for the ability of DNA computing to solve NP-complete search problems.
Fine and simplified dynamic modelling of complex hydraulic systems (2009)

This paper deals with the dynamic modelling of a complex electro-hydraulic system. Modelling is based on physical laws and the system knowledge. The main idea is to obtain a simple and reliable model that can be used for controller synthesis and implementation by using the architecture of Embedded Model Control. Simplifications are made by taking as basis the ideas of singular perturbation. A subsequent identification procedure is made in order to acquire some important parameters, required for carrying out a simulation.
New Oriented Polymer/Thermoplastic Glass Composites for IR Optics (2000)

No abstracts
Direct-Reading Spectrometer for Ferrous Analysis (1947)

The direct-reading spectrometer, previously described by Saunderson, Caldecourt, and Peterson of the Dow Chemical Company, has been adapted for ferrous analysis. Data is given on reproducibility of analytical results obtained for Ni, Cr, Si, Mn, Cu, Mo, Al, and Sn in steel. The inherent accuracy of the instrument is discussed with respect to both the electronic and photometric systems employed. Errors introduced are shown to be small compared with spectrochemical uncertainties inherent in the source.
Bioactive Compounds from the Root of Myrsine africana (1989)

Bioactivity-directed fractionation of the EtOH extract of the roots of Myrsine africana, using lethality to brine shrimp, led to the isolation and identification of emodin and 2-hydroxychrysophanol as cytotoxic components, the latter being a new natural product. Nepodin and 5-methoxy-7-hydroxyphthalide were also isolated but were not significantly cytotoxic.
Electrodeposition and Electrochemical Behavior of Palladium Particles at Polyaniline and Polypyrrole Films (1992)

The electrodeposition of palladium particles at electronically insulating polyaniline and conducting polypyrrole films in aqueous solution has been investigated. The number density of particles and their overall surface area was calculated from current transients recorded during deposition at constant potential. Both were found to depend strongly on the palladium deposition overpotential. Hydrogen adsorption and desorption, as well as hydrogen evolution, were found to take place readily on the palladium particles at polyaniline in its reduced, electronically insulating, state. Hydrogen oxidation, however, was only observed concurrently with oxidation of polyaniline to its electronically conducting state. Oxygen reduction was found to occur on Pd‐loaded polyaniline films at higher rates than similarly loaded vitreous carbon electrodes, due to larger real surface area of Pd obtained at polyaniline.
Accelerating 3D convolution using graphics hardware (case study) (1999)

Many volume filtering operations used for image enhancement, data processing or feature detection can be written in terms of three-dimensional convolutions. It is not possible to yield interactive frame rates on todays hardware when applying such convolutions on volume data using software filter routines. As modern graphics workstations have the ability to render two-dimensional convoluted images to the frame buffer, this feature can be used to accelerate the process significantly. This way generic 3D convolution can be added as a powerful tool in interactive volume visualization toolkits.
Uncertainty Estimation Using Monte-Carlo Method Constrained by Correlations of the Data (2008)

Simple and easy uncertainty estimation method is proposed. Provided that specification or simple experimental result is available, possible variance and covariance in error are estimated and Monte-Carlo simulation reflecting constraint caused by the covariance can be performed. Comparison between uncertainties obtained by the proposed method and that by actual measurements on real CMM shows good agreement within 1 m µ over-estimation.
Bacterial Cell Wall Synthesis: New Insights from Localization Studies (2005)

In order to maintain shape and withstand intracellular pressure, most bacteria are surrounded by a cell wall that consists mainly of the cross-linked polymer peptidoglycan (PG). The importance of PG for the maintenance of bacterial cell shape is underscored by the fact that, for various bacteria, several mutations affecting PG synthesis are associated with cell shape defects. In recent years, the application of fluorescence microscopy to the field of PG synthesis has led to an enormous increase in data on the relationship between cell wall synthesis and bacterial cell shape. First, a novel staining method enabled the visualization of PG precursor incorporation in live cells. Second, penicillin-binding proteins (PBPs), which mediate the final stages of PG synthesis, have been localized in various model organisms by means of immunofluorescence microscopy or green fluorescent protein fusions. In this review, we integrate the knowledge on the last stages of PG synthesis obtained in previous studies with the new data available on localization of PG synthesis and PBPs, in both rod-shaped and coccoid cells. We discuss a model in which, at least for a subset of PBPs, the presence of substrate is a major factor in determining PBP localization.
Development and evaluation of orally disintegrating film of Tramadol Hydrochloride (2013)

Orally disintegrating films offer advantage of patient compliance over conventional solid dosage forms. Present study aims at formulation and evaluation of orally disintegrating films of Tramadol Hydrochloride which disintegrate within 30 seconds. Polymers like modified pea starch (Lycoat RS 720) and pullulan were evaluated for film forming capacity and were found to form thin, smooth films at 25% w/w and 2% w/w concentration respectively. Two plasticizers, propylene glycol and sorbitol were evaluated. Taste masking of drug was done using sweetener, flavour and flavour extender. Drug content in both films was above 98% and found to release the drug within 15 minutes. Drug loaded films with both the polymers were stable under 25°C/60% RH and 40°C/75% RH conditions.
Dynamic optical imaging of vascular and metabolic reactivity in rheumatoid joints (2007)

Dynamic optical imaging is increasingly applied to clinically relevant areas such as brain and cancer imaging. In this approach, some external stimulus is applied and changes in relevant physiological parameters (e.g., oxy- or deoxyhemoglobin concentrations) are determined. The advantage of this approach is that the prestimulus state can be used as a reference or baseline against which the changes can be calibrated. Here we present the first application of this method to the problem of characterizing joint diseases, especially effects of rheumatoid arthritis (RA) in the proximal interphalangeal finger joints. Using a dual-wavelength tomographic imaging system together with previously implemented model-based iterative image reconstruction schemes, we have performed initial dynamic imaging case studies on a limited number of healthy volunteers and patients diagnosed with RA. Focusing on three cases studies, we illustrated our major finds. These studies support our hypothesis that differences in the vascular reactivity exist between affected and unaffected joints.
A new facultative anaerobe capable of growth on chlorobiphenyls. (1982)

Strain B-206 is a new facultative anaerobe, non flagellated, gram negative rod, able to grow on 4-chlorobiphenyl (4CB) and to degrade it. When this strain was grown on 4CB as sole growth substrate, two types of cultures were obtained; either the culture became pink or yellow with the formation of a black pigment. The cultures turning yellow were the more active ones and they were obtained with a large inoculum size or low oxygen tension. 4-Chlorobenzoic acid (4CBA) was detected in both pink and yellow cultures but in much higher concentration in yellow cultures. This compound appeared to be the ultimate metabolite of 4CB in both types of growth since strain B-206 could not grow or degrade 4CBA and that the concentration of 4CBA did not decrease even after the appearance of the yellow compounds. The presence of 4CBA and yellow compounds that differs spectrophotometrically at acid and basic pHs suggest that 4CB is degraded via a meta cleavage between the 1 and 2 position. The absence of any other metabolites than a pink pigment and 4CBA in the pink cultures provides no evidence that in this type of culture there would be some other mechanism of cleavage of the biphenyl molecule. In the yellow culture type, there was also formation of a black pigment. This pigment, like the pink compound, possessed all the characteristics of the phenolic type pigments. Strain B-206 could also grow on biphenyl, 3-chlorobiphenyl, 2-chlorobiphenyl, benzoic acid but it was unable to grow on any of the monochlorinated benzoic acids. Although this strain could not grow on Aroclor 1254, we have evidence that it is partially transformed by this strain.
The Great Case of The Canal vs. The Railroad - 4 Gill & Johnson 1 (1832) (1959)

This may well be Maryland's greatest case.It has unrivalled historic interest.It involved enormous stakes and brought together a galaxy of legal talent.It produced the first printed record in Maryland.It fills half a volume of our reports.But its very length repels readers, and even then its 273 pages do not tell the whole story.
A novel <i>in vivo</i> post‐translational modification of p53 by PARP‐1 in MPTP‐induced parkinsonism (2002)

Sporadic Parkinson's disease (PD) affects primarily dopaminergic neurons of the substantia nigra pars compacta. There is evidence of necrotic and apoptotic neuronal death in PD, but the mechanisms behind selected dopaminergic neuronal death remain unknown. The tumor suppressor protein p53 functions to selectively destroy stressed or abnormal cells during life and development by means of necrosis and apoptosis. Activation of p53 leads to death in a variety of cells including neurons. p53 is a target of the nuclear enzyme Poly(ADP-ribose)polymerase (PARP), and PARP is activated following DNA damage that occurs following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. MPTP is the favored in vivo model of PD, and reproduces the pathophysiology, anatomy and biochemistry of PD. p53 protein normally exhibits a fleeting half-life, and regulation of p53 stability and activation is achieved mainly by post-translational modification. We find that p53 is heavily poly(ADP-ribosyl)ated by PARP-1 following MPTP intoxication. This post-translational modification serves to stabilize p53 and alters its transactivation of downstream genes. These influences of PARP-1 on p53 may underlie the mechanisms of MPTP-induced parkinsonism and other models of neuronal death.
Role of Synaptojanin 2 in Glioma Cell Migration and Invasion (2004)

The small GTPase Rac1 is thought to play an important role in cell migration and invasion. We have previously identified synaptojanin 2, a phosphoinositide phosphatase, as an effector of Rac1. Here, we show that small interfering RNA-mediated depletion of either Rac1 or synaptojanin 2 inhibits invasion of SNB19 and U87MG glioblastoma cells through Matrigel and rat brain slices. Depletion of Rac1 or synaptojanin 2 also inhibits migration of SNB19 and U87MG cells on glioma-derived extracellular matrix. In addition, we found that depletion of Rac1 or synaptojanin 2 inhibits the formation of lamellipodia and invadopodia, specialized membrane structures that are thought to be involved in extracellular matrix degradation. These results suggest that synaptojanin 2 contributes to the role of Rac1 in cell invasion and migration by regulating the formation of invadopodia and lamellipodia. This study also identifies synaptojanin 2 as a novel potential target for therapeutic intervention in malignant tumors.
Relationship Between the Expression of bcl-2,Fas/FasL and the Apoptosis of Peripheral Lymphocytes in Patients with Systemic Lupus Erythematosus (2001)

Objective 
To study the relationship between bcl-2,Fas and Fas ligand (FasL) and the role of them in the pathogenesis of systemic lupus erythematosus (SLE).


Methods 
Flow cytometry was used.


Results 
Apoptosis of peripheral lymphocytes was significantly increased in SLE patients than that of normal controls(P<0.01)and patients with other skin diseases(P<0.05); the expression of bcl-2 antigen was significantly decreased compared with those of normal controls and patients with other skin diseases(P<0.01); whereas the differences of Fas and FasL expression among the three groups were not significant.


Conclusion 
Increased apoptosis of peripheral lymphocytes may be related to the pathogenesis of SLE,and decreased bcl-2 antigen rather than Fas/FasL route may be more important for the increased apoptosis of peripheral lymphocytes.


Key words: 
Lupus erythematosus,systemic; Lymphocytes; Apoptosis; Genes,bcl-2; Antigens,Fas; Ligand,Fas
Occupational Stress, Burnout, and Health in Teachers: A Methodological and Theoretical Analysis (1998)

The health effects of teacher stress and teacher burnout are reviewed separately in this article. Although the literature generally lends support to the hypothesis that occupational stress and burnout are associated with poor health in teachers, confidence in this conclusion is weakened by the serious methodological and conceptual difficulties that pervade this area of research. In particular, reliance on cross-sectional retrospective designs, exclusive dependence on self-report measures, and failure to adopt a theoretical framework as a guide for empirical investigations are identified as major threats to the validity of the findings reported. It is concluded that this area of research is ready for a shift to theory-based investigations that test causal models of teacher stress and health with more sophisticated research designs and measurement strategies.
Cloning of a Gene Suppressing Hydrogen Sulfide Production by <i>Saccharomyces Cerevisiae</i> and its Expression in a Brewing Yeast (1992)

NHS5, a gene suppressing formation of hydrogen sulfide (H2S), was cloned from a Saccharomyces cerevisiae X2180-1A gene library. The gene was inserted into suitable vectors and introduced into bottom-fermentation yeasts. We verified that the strain with the inserted gene was effective in beer production because the gene reduced H2S content in green beer and did not affect other fermentation characters. We also proved that the function of the gene was related to production of cystathionine β-synthase.
[Surgical cure of stress urinary incontinence with vaginal tissue sling: technique, results, indications]. (2002)

This original surgical technique for cure of urinary stress incontinence is inexpensive and easy to learn. It can be associated to other operations by vaginal way. The realization of this procedure under regional anaesthesia should enable to warn urine retention which is the mean postoperative complication. The success rate of this series is cheerful because it takes into account any patients no selected and operated on the learning phase of the technique. The best results of this technique are urinary stress incontinence associated with vaginal surgery for genital prolapse. The final assessment of this surgical technique will be require longer follow-up and comparative studies with other procedures on an elevated number of patients.
Development and Validation of Computed Tomography Derived Anthropometric Regression Equations for Estimating Abdominal Adipose Tissue Distribution (1994)

The purpose of this study was twofold: (1) to develop multiple regression equations for predicting computed tomography (CT) derived intra-abdominal (IAF), subcutaneous (SCF), and total (TOTF= IAF+SCF) abdominal adipose tissue areas from anthropometric measures in adult white males with a large range of age (18-71 years) and percent body fat (2.0-40.6); and (2) to validate the new and existing equations that used similar Hounsfield Units (HU) for determining IAF for estimating these fat depots. One hundred fifty-one white male subjects had IAF, SCF, and TOTF determined by a single CT scan, skinfold and circumference measures taken and body density determined. Linear intra-correlations and factor analysis procedures were used to identify variables for inclusion in stepwise multiple regression solutions. IAF was estimated from age, waist circumference, the sum of mid-thigh and lower thigh circumferences, and vertical abdominal skinfold. SCF was estimated from age, umbilicus circumference, chest and suprailiac skinfolds. TOTF was estimated from age, body mass index (BMI), chest skinfold, and umbilicus circumference. R2 for IAF, SCF, and TOTF was .73, .77, and .86 respectively. The existing and the new equations were validated on an independent sub-sample of 51 subjects. The only existing equation that met validation criteria had a validation R2 = .67 for IAF. All three new equations met validation criteria with R2 validations of .75, .79, and .85 for IAF, SCF, and TOTF respectively. It is concluded that the new equations might be used as an inexpensive estimation of IAF, SCF, and TOTF in adult white males varying greatly in age and percent body fat.
Inhibition of Class II Histone Deacetylases in the Spinal Cord Attenuates Inflammatory Hyperalgesia (2010)

Our data suggest that activity of class II HDACs in the spinal cord is critical to the induction and maintenance of inflammatory hyperalgesia induced by CFA, while activity of class I HDACs may be unnecessary. Comparison of the effects of HDACIs specific to class II and IIa as well as the expression pattern of different HDACs in the spinal cord in response to CFA suggests that the members of class IIa HDACs may be potential targets for attenuating persistent inflammatory pain.