gebhart/patrepeval huggingface dataset:
Adversarial Deep Structural Networks for Mammographic Mass Segmentation (2016)

Abstract Mass segmentation is an important task in mammogram analysis, providing effective morphological features and regions of interest (ROI) for mass detection and classification. Inspired by the success of using deep convolutional features for natural image analysis and conditional random fields (CRF) for structural learning, we propose an end-to-end network for mammographic mass segmentation. The network employs a fully convolutional network (FCN) to model potential function, followed by a CRF to perform structural learning. Because the mass distribution varies greatly with pixel position, the FCN is combined with position priori for the task. Due to the small size of mammogram datasets, we use adversarial training to control over-fitting. Four models with different convolutional kernels are further fused to improve the segmentation results. Experimental results on two public datasets, INbreast and DDSM-BCRP, show that our end-to-end network combined with adversarial training achieves the-state-of-the-art results.
CK20 expression, CDX2 expression, <i>K</i> ‐ <i>ras</i> mutation, and goblet cell morphology in a subset of lung adenocarcinomas (2004)

There are data in the literature that suggest a close relationship between the expression of CK20 and CDX2, K-ras mutations, and goblet cell morphology. The present study has examined these factors in a cohort of 264 non-small cell lung cancers. Thirteen of 212 adenocarcinomas expressed CK20; 29 expressed CDX2; K-ras mutation was identified in 28; and goblet cell features were present in 19. These four factors correlated with each other in a complex way and therefore a logistic regression model was constructed. Significant correlations were found between CK20 and CDX2 expression, and between K-ras mutation and goblet cell morphology, and there was a marginal correlation between CDX2 immunoreactivity and goblet cell morphology. These four features have also been commonly detected in colorectal, pancreato-biliary, and ovarian mucinous carcinomas, suggesting that these adenocarcinomas may be prototypical, independent of the organ of origin. Furthermore, as high and uniform expression of CDX2 was characteristic of metastatic colorectal cancer, weak and/or focal CDX2 expression should alert surgical pathologists to the possibility of primary lung adenocarcinoma, especially in the presence of goblet cell morphology. However, some lung adenocarcinomas may express CDX2 strongly: in this case, CK20 also tends to be positive.
Application of level changing to a multilevel storage organization (1967)

A technique for organizing the devices of a computer storage system is described. This technique, called the multilevel store, provides a means for economically satisfying the requirements for very large storage capacities of certain data management and information retrieval systems. The concept of level changing is introduced and its application to the multilevel store is discussed. A possible means for physically organizing the information for efficient use of the multilevel store is presented.
Synthesis and pharmacological properties of N-arylpiperazine-N'-alkylindanes. (1985)

Ten new compounds, N-aryl substituted piperazinealkylindanes, have been synthesized. The most active one 1-(2-[4-(3-chlorophenyl)-1-piperazinyl]-ethyl)-indane (compound 9), displayed evident central serotoninolytic properties in the 5-hydroxytryptamine (5-HTP) head twitch test in mice, as well as in the tryptamine convulsions test and the quipazine-stimulated hind paw flexor reflex test in rats.
Cholinergic Regulation of the Posterior Medial Thalamic Nucleus (2006)

We previously showed that the GABAergic nucleus zona incerta (ZI) suppresses vibrissae-evoked responses in the posterior medial (POm) thalamus of the rodent somatosensory system. We proposed that this inhibitory incertothalamic pathway regulates POm responses during different behavioral states. Here we tested the hypothesis that this pathway is modulated by the ascending brain stem cholinergic system, which regulates sleep-wake cycles and states of vigilance. We demonstrate that cholinergic inputs facilitate POm responses to vibrissae stimulation. Activation of the cholinergic system by stimulation of brain stem cholinergic nuclei (laterodorsal tegmental and the pedunculopontine tegmental) or by tail pinch significantly increased the magnitude of POm responses to vibrissae stimulation. Microiontophoresis of the muscarinic receptor agonist carbachol enhanced POm responses to vibrissae stimulation. Application of carbachol to an in vitro slice preparation reduced the frequency but not the amplitude of miniature inhibitory postsynaptic currents, indicating a presynaptic site of action for carbachol. We conclude that the cholinergic system facilitates POm responses by suppressing GABAergic inputs from ZI. We propose the state-dependent gating hypothesis, which asserts that differing behavioral states, regulated by the brain stem cholinergic system, modulate the flow of information through POm.
Speech dereverberation and noise reduction with a combined microphone array approach (2002)

In this contribution we have addressed the problem of speech enhancement in noisy and reverberant rooms through the use of a new approach that combines the dereverberation abilities of a structure based in the separate processing of the minimum-phase and all-pass components of the input speech signals, and the noise rejection performance of a speech-activity-based Wiener filter able to cope both with coherent and diffuse noise. Experiments have been performed with the CMU real multichannel database, which includes a clean speech reference through a head-mounted microphone. This reference signal have been also used to perform simulation experiments in controlled conditions. Extensive results have been obtained, both with log area ratio and cepstral distances of input and processed signals to the reference, and with segSNR improvements, assessing the abilities of the new system to cope both with reverberation and coherent and diffuse noise in different acoustic environments.
Gamma Interferon Is Not Required for Mucosal Cytotoxic T-Lymphocyte Responses or Heterosubtypic Immunity to Influenza A Virus Infection in Mice (2000)

Heterosubtypic immunity (HSI) is defined as cross-protection against influenza virus of a different serotype than the virus initially encountered and is thought to be mediated by influenza virus-specific cytotoxic T lymphocytes (CTL). Since gamma interferon (IFN-gamma) stimulates cytotoxic cells, including antigen-specific CTL which may control virus replication by secretion of antiviral cytokines such as tumor necrosis factor alpha and IFN-gamma, we have investigated the mechanism of HSI by analyzing the role of IFN-gamma for HSI in IFN-gamma gene-deleted (IFN-gamma(-/-)) mice. It has been reported that IFN-gamma is not required for recovery from primary infection with influenza virus but is important for HSI. Here, we conclusively show that IFN-gamma is not required for induction of secondary influenza virus-specific CTL responses in mediastinal lymph nodes and HSI to lethal influenza A virus infection. Although T helper 2 (Th2)-type cytokines were upregulated in the lungs of IFN-gamma(-/-) mice after virus challenge, either Th1- or Th2-biased responses could provide heterosubtypic protection. Furthermore, titers of serum-neutralizing and cross-reactive antibodies to conserved nucleoprotein in IFN-gamma(-/-) mice did not differ significantly from those in immunocompetent mice. These results indicate that lack of IFN-gamma does not impair cross-reactive virus-specific immune responses and HSI to lethal infection with influenza virus. Our findings provide new insight for the mechanisms of HSI and should be valuable in the development of protective mucosal vaccines against variant virus strains, such as influenza and human immunodeficiency virus.
Mesoporous graphene-like carbon sheet: high-power supercapacitor and outstanding catalyst support (2014)

Nowadays, continuous scientific endeavors are being directed toward low-cost, mild, scalable and reliable synthesis of graphene-based materials, in order to advance various graphene-related applications.
Fuzzy sliding mode lateral control of intelligent vehicle based on vision (2013)

Lateral control of intelligent vehicle is investigated taking the intelligent vehicle DLUIV-1 based on visual navigation as the control object.Firstly,the system model of vehicle lateral control based on visual preview distance is established.The lateral error and direction error are calculated making use of the model of vehicle preview kinematics containing speed and other factors.Secondly,an efficient strategy of fuzzy sliding mode lateral control for intelligent vehicle is proposed according to the characteristics of lateral control.The integration of the vehicle current lateral error and direction error is chosen as the parameter of the sliding mode switching function to design the sliding surface.The value of the control variable is adjusted according to the fuzzy control rules to ensure that it meets the existence and reaching condition taking sliding mode switching function as the control target,and ensure the stability of the steering wheel rotation.Simulation results show that the lateral controller can guarantee high path-tracking accuracy and strong robustness for the change of model parameters.
Nanobiotechnology today: focus on nanoparticles (2007)

In the recent years the nanobiotechnology field and the Journal of Nanobiotechnology readership have witnessed an increase in interest towards the nanoparticles and their biological effects and applications. These include bottom-up and molecular self-assembly, biological effects of naked nanoparticles and nano-safety, drug encapsulation and nanotherapeutics, and novel nanoparticles for use in microscopy, imaging and diagnostics. This review highlights recent Journal of Nanobiotechnology publications in some of these areas http://www.jnanobiotechnology.com.
Centralized Lightwave WDM-PON Employing 16-QAM Intensity Modulated OFDM Downstream and OOK Modulated Upstream Signals (2008)

We have proposed and experimentally demonstrated a novel architecture for orthogonal frequency-division- multiplexing (OFDM) wavelength-division-multiplexing passive optical network with centralized lightwave. In this architecture, 16 quadrature amplitude modulation intensity-modulated OFDM signals at 10 Gb/s are utilized for downstream transmission. A wavelength-reuse scheme is employed to carry the upstream data to reduce the cost at optical network unit. By using one intensity modulator, the downstream signal is remodulated for upstream on-off keying (OOK) data at 2.5 Gb/s based on its return-to-zero shape waveform. We have also studied the fading effect caused by double-sideband (DSB) downstream signals. Measurement results show that 2.5-dB power penalty is caused by the fading effect. The fading effect can be removed when the DSB OFDM downstream signals are converted to single sideband (SSB) after vestigial filtering. The power penalty is negligible for both SSB OFDM downstream and the remodulated OOK upstream signals after over 25-km standard single-mode-fiber transmission. Index
Secondary control for reactive power sharing in droop-controlled islanded microgrids (2012)

This paper focuses on the islanded operation of microgrids. In this mode of operation, the microsources are required to cooperate autonomously to regulate the local grid voltage and frequency. Droop control is typically used to achieve this autonomous voltage and frequency regulation. However, droop control has real and reactive power sharing limitations when there are mismatches between the microsources. This paper analyses the effect due to mismatches in the power line impedances connecting the source inverters to the microgrid. From the simulations results obtained, it was shown that the reactive power demand is unequally shared between the microsource inverters when there are mismatches between the power line impedances. To achieve equal reactive power sharing between the inverters, an external loop requiring low bandwidth communications was implemented in a central controller. Simulation results are presented showing the feasibility of the proposed solution in achieving reactive power sharing between the inverters connected to the microgrid.
The Genome of Archaeal Prophage ΨM100 Encodes the Lytic Enzyme Responsible for Autolysis of <i>Methanothermobacter wolfeii</i> (2001)

Methanothermobacter wolfeii (formerly Methanobacterium wolfei), a thermophilic methanoarchaeon whose cultures lyse upon hydrogen starvation, carries a defective prophage called PsiM100 on its chromosome. The nucleotide sequence of PsiM100 and its flanking regions was established and compared to that of the previously sequenced phage PsiM2 of Methanothermobacter marburgensis (formerly Methanobacterium thermoautotrophicum Marburg). The PsiM100 genome extends over 28,798 bp, and its borders are defined by flanking 21-bp direct repeats of a pure-AT sequence, which very likely forms the core of the putative attachment site where the crossing over occurred during integration. A large fragment of 2,793 bp, IFa, apparently inserted into PsiM100 but is absent in the genome of PsiM2. The remaining part of the PsiM100 genome showed 70.8% nucleotide sequence identity to the whole genome of PsiM2. Thirty-four open reading frames (ORFs) on the forward strand and one ORF on the reverse strand were identified in the PsiM100 genome. Comparison of PsiM100-encoded ORFs to those encoded by phage PsiM2 and to other known protein sequences permitted the assignment of putative functions to some ORFs. The ORF28 protein of PsiM100 was identified as the previously known autolytic enzyme pseudomurein endoisopeptidase PeiW produced by M. wolfeii.
Bcl-2,Bax andp53 expression in B-CLL in relation toin vitro survival and clinical progression (1996)

Our previous data have shown that isolated leukemic cells from progressive chronic lymphocytic leukemia (B-CLL) patients respond to growth stimulation in vitro and express high levels of p53, immunoreactive with the configuration-specific antibody PAb 240. We have now analyzed the in vitro survival of B-CLL cells in relation to Bcl-2, Bax alpha and p53 expression and compared this with the clinical progression of the disease. Leukemic cells from patients with progressive disease demonstrated higher in vitro survival, compared with non-progressive B-CLL and normal B cells. All cells were sensitive to treatment with a combination of glucocorticoid and cAMP. Bcl-2 protein levels were not related to clinical progression, as measured by flow cytometry. Competitive PCR showed that Bcl-2 mRNA was over-expressed in most of the B-CLL samples and that p53 mRNA expression was similar between B-CLL groups and normal values and thus not related to clinical progression. However, since Bax alpha expression was lower in progressive than in non-progressive patients, the Bcl-2/Bax alpha ratio at the mRNA level was significantly higher in the progressive group. Our data suggest that the Bcl-2/Bax alpha ratio is important for the regulation of B-CLL cell survival, that p53 over-expression in progressive B-CLL is the result of post-transcriptional modifications and that a directed PKA activation may potentiate the cytolytic effect of glucocorticoids in vivo.
Application of Meridian Electrical Conductance in the Setting of Acute Ischemic Stroke: A Cross-Sectional Study (2019)

Acupuncture is widely used for improving poststroke care. Knowing the condition of meridian can help traditional Chinese medicine (TCM) doctors make a tailored choice of acupoints for every patient. The establishment of an objective meridian energy measurement for acute ischemic stroke that can be used for future acupuncture treatment and research is an important area in stroke-assisted therapy. In this study, a total of 102 subjects diagnosed with acute ischemic stroke within 7 days of onset were recruited, and the meridian energy analysis device (MEAD) was used to record the meridian electrical conductance (MEC) values of twelve meridians on unaffected and affected limbs. We found that the MEC value of the twelve meridians on the affected limbs was significantly higher than that on the unaffected limbs (<i>P</i>=0.001). Compared with the unaffected limbs, there was a higher value of MEC on the affected limbs of the lung meridian, heart meridian, pericardium meridian, and small intestine meridian, with significant differences (<i>P</i> < 0.05, <i>P</i> < 0.001, <i>P</i> < 0.001, and <i>P</i> < 0.05, respectively). Further analysis revealed that the MEC values of both Yin and Yang meridians of the affected limbs were significantly higher than those of the unaffected limbs (<i>P</i>=0.001 and <i>P</i> < 0.05, respectively). Meanwhile, the mean of the index of sympathovagal balance in patients with acute ischemic stroke (5.49 ± 4.21) was higher than the normal range (1-1.5), indicating autonomic imbalance. The results of this study are consistent with TCM theory as well as clinical observation and pathological mechanisms, suggesting that the measurement of MEC values may be used as a supplementary diagnostic method for acupuncture in patients with acute ischemic stroke.
Embedding spectral analysis in equipment (1991)

The use of digital signal processors (DSPs) that enable continuous estimates of signal frequency components to be incorporated into a broad range of real-time systems is considered. Classical spectral estimation methods are reviewed. Real-time implementation of the methods, all of which use some form of fast Fourier transform method, on DSP chips is discussed. Some applications of these chips are examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Role of PCSK9 Inhibitors in the Treatment of Hypercholesterolemia (2018)

The PCSK9 inhibitor drug class is an effective LDL-C lowering option for patients with the highest risk of CVD events and high LDL-C despite the use of statin therapy. For more widespread use, significant cost reductions are needed.
Bracketing NCAA women’s volleyball tournament (2019)

Models were developed using seasonal averages, and ranks of seasonal averages, to predict winners of the various rounds of the NCAA Division 1 Women’s Volleyball tournament. Data used to develop these models was collected during 2011-2013. These models were used to predict winners of the 2015 tournament matches and the overall winner. A match statistic model was also developed using data from actual matches played in the NCAA Women’s Tournament in 2015. The match statistic model was used to predict winners of the matches in the 2016 tournament and the overall winner. It was found that models based on using seasonal averages performed better at predicting the winners of the matches and then the overall tournament than the models developed using match statistics replacing match statistics with seasonal averages of the corresponding statistics. Results are given.
Mitigating control-channel jamming attacks in multi-channel ad hoc networks (2009)

We address the problem of control-channel jamming attacks in multi-channel ad hoc networks. Deviating from the traditional view that sees jamming attacks as a physical-layer vulnerability, we consider a sophisticated adversary who exploits knowledge of the protocol mechanics along with cryptographic quantities extracted from compromised nodes to maximize the impact of his attack on higher-layer functions. We propose new security metrics that quantify the ability of the adversary to deny access to the control channel, and the overall delay incurred in re-establishing the control channel. We also propose a randomized distributed scheme that allows nodes to establish a new control channel using frequency hopping. Our method differs from classic frequency hopping in that no two nodes share the same hopping sequence, thus mitigating the impact of node compromise. Furthermore, a compromised node is uniquely identified through its hop sequence, leading to its isolation from any future information regarding the frequency location of the control channel.
Histologic Spectrum of Diversion Colitis (1990)

Biopsy specimens taken from six patients with diversion colitis, an inflammatory process that occurs in the bypassed colonic segment after diversion of the fecal stream, showed a spectrum of histologic changes ranging from mild colitis to those seen in severe active chronic ulcerative colitis. Histologic abnormalities included aphthous ulcers, crypt distortion, atrophy and abscesses, a villous colonic surface, and a mixed acute and chronic inflammatory infiltrate with patchy lymphoid hyperplasia. Accurate pathologic diagnosis is dependent on clinical history, comparison of histologic morphology in both colonic segments, and response to therapy with local application of short chain fatty acids.
Surface Reconstruction from Multi-View Stereo of Large-Scale Outdoor Scenes (2010)

This article describes an original method to reconstruct a 3D scene from a sequence of images. Our approach uses both the dense 3D point cloud extracted by multi-view stereovision and the calibrated images. It combines depth-maps construction in the image planes with surface reconstruction through restricted Delaunay triangulation. The method may handle very large scale outdoor scenes. Its accuracy has been tested on numerous outdoor scenes including the dense multi-view benchmark proposed by Strecha et al. Our results show that the proposed method compares favorably with the current state of the art.
Improvement of amplified spontaneous emission by encapsulating green fluorescent dye in inverted-opal titania photonic crystals (2008)

Amplified spontaneous emission (ASE) characteristics of a green fluorescent dye (10-(2-benzothiazolyl)-1,1,7,7-tetramethyl-2,3,6,7-tetrahydro-1H,5H,11H-[1] benzo- pyrano [6,7,8-ij]quinolizin-11-one) (C545T) encapsulated in a highly ordered three-dimensional (3D) inverted-opal titania (TiO(2)) photonic crystal (PC) microcavity were studied. Due to the utilization of a TiO(2) PC, the emission spectrum was greatly narrowed and the ASE threshold, gain, and loss were significantly improved. The threshold, gain, and loss reached 1.25 mJ pulse(-1) cm(-2), 34.69 cm(-1), and 16.9 cm(-1), respectively. The possible reason for the improvement in the ASE performance by the PC is attributed to the 3D photon localization by the microcavity effect of the PC.