gebhart/patrepeval huggingface dataset:
Synthetic studies on terpenoids. Part XVIII. Stereocontrolled synthesis of (±)-1,2,3,4,4a,9,10,10aα-octahydro-1α-methylphenanthrene-1β,4aβ-dicarboxylic acid and the 7-methoxy-analogue: a potential intermediate for diterpenoid syntheses (1976)

A stereocontrolled synthetic route to (±)-1,2,3,4,4a,9,10,10aα-octahydro-1α-methylphenanthrene-1β,4aβ-di-carboxylic acid (Ia) and the 7-methoxy-analogue (Ib) is described. The present approach differs basically from earlier ones and proceeds through polyhydrobenzindenone intermediates. 2,3,4,5-Tetrahydro-3-methylbenz[e] inden-1-one (Va) and the corresponding 7-methoxy-compound (Vb) were transformed through several steps into cis-9b-acetonyl-3a,4,5,9b-tetrahydro-3-methylbenz[e]inden-1-one (XIIIa) and its methoxy-derivative (XIIIb). These unsaturated diketones underwent intramolecular Michael condensation, affording tetracyclic bridged ketones (XIVa and b), which were converted into the acids (Ia and b). In the methoxy-series, disproportionation of a polyhydrobenzindenone derivative was noted.
CHEMDNER: The drugs and chemical names extraction challenge (2015)

Natural language processing (NLP) and text mining technologies for the chemical domain (ChemNLP or chemical text mining) are key to improve the access and integration of information from unstructured data such as patents or the scientific literature. Therefore, the BioCreative organizers posed the CHEMDNER (chemical compound and drug name recognition) community challenge, which promoted the development of novel, competitive and accessible chemical text mining systems. This task allowed a comparative assessment of the performance of various methodologies using a carefully prepared collection of manually labeled text prepared by specially trained chemists as Gold Standard data. We evaluated two important aspects: one covered the indexing of documents with chemicals (chemical document indexing - CDI task), and the other was concerned with finding the exact mentions of chemicals in text (chemical entity mention recognition - CEM task). 27 teams (23 academic and 4 commercial, a total of 87 researchers) returned results for the CHEMDNER tasks: 26 teams for CEM and 23 for the CDI task. Top scoring teams obtained an F-score of 87.39% for the CEM task and 88.20% for the CDI task, a very promising result when compared to the agreement between human annotators (91%). The strategies used to detect chemicals included machine learning methods (e.g. conditional random fields) using a variety of features, chemistry and drug lexica, and domain-specific rules. We expect that the tools and resources resulting from this effort will have an impact in future developments of chemical text mining applications and will form the basis to find related chemical information for the detected entities, such as toxicological or pharmacogenomic properties.
A modified probabilistic data association filter in a real clutter environment (1996)

A new multiple target tracking algorithm for tracking in clutter is developed. The new algorithm uses a modified Hough transform (HT) for track initiation and a directional probability data association (DPDA) filter for data association (DA). Two basic criteria are used to distinguish the tracks from clutter during the track initiation phase. Returns from only five radar scans are required. The DPDA incorporates the directional information and the association probabilities are estimated using both Mahalanobis distance and the track direction. This algorithm is designed for target tracking where the effect of clutter is considered to be severe. Simulated data as well as real radar data are used to evaluate the performance of this new tracking system.
Homoleptic Isocyanidemetalates of 4d- and 5d-Transition Metals:  [Nb(CNXyl)<sub>6</sub>]<sup>-</sup>, [Ta(CNXyl)<sub>6</sub>]<sup>-</sup>, and Derivatives Thereof<sup>1</sup> (2007)

Treatment of [M(CO)(6)](-), M = Nb, Ta, with Ag(+), I(2) or NO(+) in the presence of CNXyl provided [M(CNXyl)(7)](+), M(CNXyl)(6)I, or cis-[M(CNXyl)(4)(NO)(2)](+), which are isocyanide analogues of the unknown carbonyl complexes [M(CO)(7)](+), M(CO)(6)I, or cis-[M(CO)(4)(NO)(2)](+), respectively. Reduction of M(CNXyl)(6)I by cesium graphite gave the respective Cs[M(CNXyl)(6)], which have been structurally characterized and represent the first isolable homoleptic isocyanidemetalates for second or third row transition metals. Nitrosylation of [Ta(CNXyl)(6)](-) affords a rare example of a mononitrosyl tantalum complex, Ta(CNXyl)(5)NO, which is an isocyanide analogue of the unknown Ta(CO)(5)NO. This study emphasizes, inter alia, the remarkable versatility of the CNXyl ligand compared to CO in stabilizing various electronic environments at heavier group 5 metal centers.
ChemInform Abstract: PYRIMIDINES. LXII. SOME REACTIONS OF PYRIMIDINE CYANO DERIVATIVES (1977)

Abstract Zur Herstellung von Amino‐cyan‐pyrimidinen werden die Dimethylpyrimidine (I) und (V) mit salpetriger Säure zu Oximen nitrosiert, aus denen durch Behandlung mit Phosphoroxychlorid die Cyanpyrimidine (II) und (III) entstehen.
Biodegradation of p-nitrophenol via 1,2,4-benzenetriol by an Arthrobacter sp (1994)

The degradation of p-nitrophenol (PNP) by Moraxella and Pseudomonas spp. involves an initial monooxygenase-catalyzed removal of the nitro group. The resultant hydroquinone is subject to ring fission catalyzed by a dioxygenase enzyme. We have isolated a strain of an Arthrobacter sp., JS443, capable of degrading PNP with stoichiometric release of nitrite. During induction of the enzymes required for growth on PNP, 1,2,4-benzenetriol was identified as an intermediate by gas chromatography-mass spectroscopy (GC-MS) and radiotracer studies. 1,2,4-Benzenetriol was converted to maleylacetic acid, which was further degraded by the beta-ketoadipate pathway. Conversion of PNP to 1,2,4-benzenetriol is catalyzed by a monooxygenase system in strain JS443 through the formation of 4-nitrocatechol, 4-nitroresorcinol, or both. Our results clearly indicate the existence of an alternative pathway for the biodegradation of PNP.
Breast cancer diagnostics based on extracellular DNA and RNA circulating in blood (2008)

Extracellular DNA and RNA were extracted from blood plasma and cell surface-bound fractions of patients with breast tumors and healthy controls. Frequency of RASSF1A, Cyclin D2 and RARbeta2 methylation was detected using methylation-specific PCR in the extracellular DNA, extracted from plasma and cell-surface bound fractions of patient blood. Methylation of at least one of these genes was found in plasma of 13% patients with benign breast fibroadenoma and in 60% of breast cancer patients. Using cell-surface bound DNA as a substrate for PCR have lead to increase of gene methylation detection frequency up to 87% in fibroadenoma and 95% in breast cancer patients without false positive controls. GAPDH, RASSF8, Ki-67 RNA and 18S RNA were quantified using RT-qPCR of the extracellular RNA circulating in blood of patients with breast tumors and healthy controls. The main part of the extracellular RNA was shown to be cell-surface bound. Results show a higher amount of RASSF8, Ki-67 RNA and 18S RNA in plasma and cell-bound fraction of patients with breast cancer compared with patients with benign tumors and healthy controls. The data indicate that the specific RNA quantification in blood plasma is valuable for discrimination between cancer and benign tumors, which can be detected with high sensitivity using analysis of methylated RASSF1A, Cyclin D2 and RARbeta2 genes in extracellular circulating DNA.
Interaction of the Vitamin D Receptor with a Vitamin D Response Element in the Mullerian-Inhibiting Substance (MIS) Promoter: Regulation of MIS Expression by Calcitriol in Prostate Cancer Cells (2008)

Calcitriol (1,25-dihydroxyvitamin D(3)) inhibits the growth of a variety of cancer cells including human prostate cancer. Müllerian-inhibiting substance (MIS) also exhibits antiproliferative and proapoptotic actions on multiple cancer cells including human prostate cancer. In this study, we investigated whether calcitriol regulated MIS expression in prostate cancer, an action that might contribute to its antiproliferative activity. We identified a 15-bp sequence, GGGTGAgcaGGGACA, in the MIS promoter that was highly similar to direct repeat 3-type vitamin D response elements (VDREs). The human MIS promoter containing the putative VDRE was cloned into a luciferase reporter vector. In HeLa cells transfected with the vitamin D receptor (VDR), MIS promoter activity was stimulated by calcitriol. Coexpression of steroidogenic factor 1, a key regulator of MIS, increased basal MIS promoter activity that was further stimulated by calcitriol. Mutation or deletion of the VDRE reduced calcitriol-induced transactivation. In addition, the MIS VDRE conferred calcitriol responsiveness to a heterologous promoter. In gel shift assays, VDR and retinoid X receptor bound to the MIS VDRE and the binding was increased by calcitriol. Chromatin immunoprecipitation assays showed that VDR and retinoid X receptor were present on the MIS promoter in prostate cancer cells. In conclusion, we demonstrated that MIS is a target of calcitriol action. MIS is up-regulated by calcitriol via a functional VDRE that binds the VDR. Up-regulation of MIS by calcitriol may be an important component of the antiproliferative actions of calcitriol in some cancers.
Computational prosodic markers for autism (2010)

We present results obtained with new instrumental methods for the acoustic analysis of prosody to evaluate prosody production by children with Autism Spectrum Disorder (ASD) and Typical Development (TD). Two tasks elicit focal stress — one in a vocal imitation paradigm, the other in a picture-description paradigm; a third task also uses a vocal imitation paradigm, and requires repeating stress patterns of two-syllable nonsense words. The instrumental methods differentiated significantly between the ASD and TD groups in all but the focal stress imitation task. The methods also showed smaller differences in the two vocal imitation tasks than in the picture-description task, as was predicted. In fact, in the nonsense word stress repetition task, the instrumental methods showed better performance for the ASD group. The methods also revealed that the acoustic features that predict auditory-perceptual judgment are not the same as those that differentiate between groups. Specifically, a key difference between the groups appears to be a difference in the balance between the various prosodic cues, such as pitch, amplitude, and duration, and not necessarily a difference in the strength or clarity with which prosodic contrasts are expressed.
Biological Degradation of Wood (1989)

Wood is decomposed by a variety of biological agents, including fungi, bacteria, and insects. Fungi colonize wood and degrade cell wall components to form brown, soft, or white rot. Brown-rot fungi, which degrade primarily the polysaccharide components of wood, leave a lignin framework. White-rot fungi may degrade all cell wall components. The rate and extent of lignin, cellulose, and hemicellulose removal varies among species of white-rot fungi. Soft-rot fungi erode the secondary wall or form discrete cavities within the cell wall. Each type of decay has many forms and can be classified by microscopic and ultrastructural characteristics. Bacteria can directly attack wood to cause erosion, cavitation, and tunneling patterns of deterioration. Bacteria may have a syngeristic or antagonistic effect on other microorganisms that inhabit wood. This chapter reviews the morphological and chemical changes that occur in wood after degradation by different microorganisms and provides information that will help identify the types of deterioration found in wood of historic value.
Advancements in at-speed array BIST: multiple improvements (2007)

This paper discusses the unique challenges in constructing an architecture and methodology for testing a 1 GHz 65 nm Embedded DRAM in an ASIC environment. The concepts of multiplication of both test commands and test clock frequency are discussed in detail. The novel technique of command multiplication is thoroughly explored. The inherent benefits of this design point is examined as it relates to test circuit design, BIST sharing, and chip level wiring in comparison to traditional scan or parallel based array BIST architectures. Attention is also paid to various methods used for supporting at-speed/high-speed test clock generation from a low speed tester and the important influence this has on test cost and test quality.
Suppression of lymphocyte proliferation by a retroviral p15E‐derived hexapeptide (1992)

CKS-17 (LQNRRGLDLLFLKEGGL), a synthetic peptide derived from a conserved region of retroviral transmembrane proteins, has previously been shown to suppress several different immune effector mechanisms. The present study was undertaken to further delineate immunosuppressive site(s) of CKS-17. Overlapping hexapeptides covering the complete sequence of CKS-17 were synthesized. One CKS-17-derived hexapeptide, LDLLFL, suppressed ligand [CD3, interleukin (IL)-2]-induced lymphocyte proliferation. Spontaneous proliferation of transformed lymphoid cell lines, as well as cell lines from myeloid or epitheloid origin, was not inhibited by LDLLFL. Full suppression required the continuous presence of LDLLFL during culturing, and did not involve interference with monocyte function. Radiolabeling studies showed that the hexapeptide did not compete with IL-2 for IL-2 receptor binding. Most likely the LDLLFL motif interferes with steps shared by the IL-2 and CD3 receptor-induced signaling pathways. Since LDLLFL displays multiple immunosuppressive activities, it may constitute a biologically relevant immunosuppressive site of retroviral transmembrane proteins.
Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohnʼs disease (2009)

MH induced by long-term maintenance IFX treatment is associated with an improved long-term outcome of the disease especially with a lower need for major abdominal surgeries.
A High-Efficiency PV Module-Integrated DC/DC Converter for PV Energy Harvest in FREEDM Systems (2011)

The future renewable electric energy delivery and management (FREEDM) system provides a dc interface for alternative energy sources. As a result, photovoltaic (PV) energy can be easily delivered through a dc/dc converter to the FREEDM system's dc bus. The module-integrated converter (MIC) topology is a good candidate for a PV converter designed to work with the FREEDM system. This paper compares the parallel connected dc MIC structure with its counterpart, the series connected MIC architecture. From the presented analysis, the parallel connected architecture was shown to have more advantages. In this paper, a high-efficiency dual mode resonant converter topology is proposed for parallel connected dc MICs. This new resonant converter topology can change resonant modes adaptively depending on the panel operation conditions. The converter achieves zero-voltage switching for primary-side switches and zero-current switching for secondary-side diodes for both resonant modes. The circulation energy is minimized particularly for 5-50% of the rated power level. Thus, the converter can maintain a high efficiency for a wide input range at different output power levels. This study explains the operation principle of the proposed converter and presents a dc gain analysis based on the fundamental harmonic analysis method. A 240-W prototype with an embedded maximum power point tracking controller was built to evaluate the performance of the proposed converter. The prototype's maximum efficiency reaches 96.5% and an efficiency increase of more than 10% under light load conditions is shown when compared with a conventional LLC resonant converter.
MOF-Sensitized Solar Cells Enabled by a Pillared Porphyrin Framework (2017)

Metal–organic frameworks (MOFs) are highly ordered, functionally tunable supramolecular materials with the potential to improve dye-sensitized solar cells (DSSCs). Several recent reports have indicated that photocurrent can be generated in Grätzel-type DSSC devices when MOFs are used as the sensitizer. However, the specific role(s) of the incorporated MOFs and the potential influence of residual MOF precursor species on device performance are unclear. Herein, we describe the assembly and characterization of a simplified DSSC platform in which isolated MOF crystals are used as the sensitizer in a planar device architecture. We selected a pillared porphyrin framework (PPF) as the MOF sensitizer, taking particular care to avoid contamination from light-absorbing MOF precursors. Photovoltaic and electrochemical characterization under simulated 1-sun and wavelength-selective illumination revealed photocurrent generation that is clearly ascribable to the PPF MOF. Continued refinement of highly versatile MOF structure and chemistry holds promise for dramatic improvements in emerging photovoltaic technologies.
THE REARRANGEMENT OF ARYL-SUBSTITUTED PROPYNES TO ALLENES<sup>1</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE REARRANGEMENT OF ARYL-SUBSTITUTED PROPYNES TO ALLENES1THOMAS L. JACOBS and STANLEY SINGERCite this: J. Org. Chem. 1952, 17, 3, 475–481Publication Date (Print):March 1, 1952Publication History Published online1 May 2002Published inissue 1 March 1952https://pubs.acs.org/doi/10.1021/jo01137a023https://doi.org/10.1021/jo01137a023research-articleACS PublicationsRequest reuse permissionsArticle Views254Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CLXIV.—Tertiary phosphines containing the higher alkyl radicals (1929)

W. C. Davies, P. L. Pearse and W. J. Jones, J. Chem. Soc., 1929, 1262 DOI: 10.1039/JR9290001262
Differential effects of fluticasone and montelukast on allergen‐induced asthma (2004)

Early asthmatic responses (EAR) and late asthmatic responses (LAR) to allergen are induced by the local release of a series of bronchoconstrictor mediators, including leukotrienes and histamine. Both anti-leukotrienes and other anti-asthma drugs, such as inhaled glucocorticoids, have been shown to reduce both EAR and LAR. The aim of the present study was to directly compare the effects of regular treatment with an oral anti-leukotriene, montelukast (Mont; 10 mg once daily, for 8 days), and an inhaled glucocorticoid [fluticasone propionate (FP) 250 microg twice daily for 8 days] on the EAR and LAR to an inhaled allergen challenge. Patients with a documented EAR and LAR at a screening visit were randomized to these treatments, or placebo, in a double-blind, double-dummy, crossover fashion. Allergen challenge at a dose causing both an EAR and LAR was given on the eighth day of treatment. The maximum fall in FEV1 during the EAR was 17.8% during placebo treatment, 8.3% during Mont and 16.3% during FP (P <0.05 for Mont vs placebo). The maximum fall during the EAR was 13.8% during placebo treatment, 11.8% during Mont and 2% during FP treatment (P <0.05 for FP vs placebo and FP vs Mont). PC20 methacholine was significantly higher 24 h after allergen challenge during FP-treatment compared with Mont (P <0.05). Both montelukast and fluticasone reduced the relative amount of sputum eosinophils after allergen compared with placebo treatment. This study shows that anti-leukotrienes are effective to attenuate the EAR, whereas inhaled glucocorticoids are more effective than anti-leukotrienes in attenuating the EARs and improves bronchial hyperresponsiveness to a greater extent. In conclusion, inhaled glucocorticoids have overall greater efficacy than oral anti-leukotrienes to attenuate allergen-induced airway responses in mild asthmatic patients.
Immunological identification of five troponin T isoforms reveals an elaborate maturational troponin T profile in rabbit myocardium. (1989)

Myocardium is generally thought to express no more than two isoforms of troponin T (TnT). We have recently reported that TnT purified from rabbit myocardium is resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis into five proteins (TnT1, TnT2, TnT3, TnT4, and TnT5). In this study, these proteins are characterized immunologically and a novel elaborate maturational profile is described. Myocardium was obtained from 23 days of gestation fetal rabbits and 2-day, 6-week, 3-month, and 6-month postnatal rabbits. The major species in the adult myocardium, TnT4, was identified on sodium dodecyl sulfate-polyacrylamide gels and excised. The protein was electroeluted and purified. An amino acid microsequence of a cleaved fragment of this protein was found to be virtually identical to residues 86-99 from adult rabbit cardiac TnT. The protein, TnT4, was used to raise a polyclonal antibody. This antibody recognized all five isoforms from purified cardiac TnT, but none of the TnT isoforms from fast skeletal muscle. A monoclonal antibody, Mab JLT-12, raised against a highly conserved epitope of rabbit fast skeletal muscle, recognized all five cardiac as well as five skeletal muscle isoforms. Western blots performed on intact myocardial preparations demonstrated that TnT1, the cardiac isoform with the slowest electrophoretic mobility, was expressed prominently in the immature hearts, in addition to TnT2, TnT3, and TnT4, but TnT1 was not evident in the 3-month and 6-month postnatal hearts. The expression of TnT2 also decreased with maturation. Thus, the number of TnT isoforms expressed in the rabbit decreases with maturation.(ABSTRACT TRUNCATED AT 250 WORDS)
Low power network processor design using clock gating (2005)

Network processors (NPs) have emerged as successful platforms to providing both high performance and flexibility in building powerful routers. Typical NPs incorporate multiprocessing and multi-threading to achieve maximum parallel processing capabilities. We observed that under low incoming traffic rates, most processing elements (PEs) in NPs are nearly idle and yet still consume dynamic power. This paper develops a low power technique to reduce the activities of PEs according to the varying traffic volume. We propose to monitor the average number of idle threads in a time window, and gate off the clock network of unused PEs when a subset of PEs is enough to handle the network traffic. We show that our technique brings significant reduction in power consumption (up to 30%) of NPs with no packet loss and little impact to the overall throughput.