gebhart/patrepeval huggingface dataset:
Fiber-optic probe for noninvasive real-time determination of tissue optical properties at multiple wavelengths (2001)

We present a compact, fast, and versatile fiber-optic probe system for real-time determination of tissue optical properties from spatially resolved continuous-wave diffuse reflectance measurements. The system collects one set of reflectance data from six source-detector distances at four arbitrary wavelengths with a maximum overall sampling rate of 100 Hz. Multivariate calibration techniques based on two-dimensional polynomial fitting are employed to extract and display the absorption and reduced scattering coefficients in real-time mode. The four wavelengths of the current configuration are 660, 785, 805, and 974 nm, respectively. Cross-validation tests on a 6 x 7 calibration matrix of Intralipid-dye phantoms showed that the mean prediction error at, e.g., 785 nm was 2.8% for the absorption coefficient and 1.3% for the reduced scattering coefficient. The errors are relative to the range of the optical properties of the phantoms at 785 nm, which were 0-0.3/cm for the absorption coefficient and 6-16/cm for the reduced scattering coefficient. Finally, we also present and discuss results from preliminary skin tissue measurements.
The Proximity-Fixation-Disparity Curve and the Preferred Viewing Distance at a Visual Display as an Indicator of Near Vision Fatigue (2002)

Thus, this steep proximity-FD curve indicates a weak disparity vergence system that may cause near vision fatigue. This may explain why some young adults prefer longer viewing distances at the computer workstation.
Differential RNA Expression Profile by cDNA Microarray in Sporadic Primary Hyperparathyroidism (pHPT): Primary Parathyroid Hyperplasia versus Adenoma (2006)

Our data suggest that SPH and adenoma have a singular molecular signature that, theoretically, could be used for the differential diagnosis of these entities and normal parathyroid tissue.
NeuCode Labels for Relative Protein Quantification (2014)

We describe a synthesis strategy for the preparation of lysine isotopologues that differ in mass by as little as 6 mDa. We demonstrate that incorporation of these molecules into the proteomes of actively growing cells does not affect cellular proliferation, and we discuss how to use the embedded mass signatures (neutron encoding (NeuCode)) for multiplexed proteome quantification by means of high-resolution mass spectrometry. NeuCode SILAC amalgamates the quantitative accuracy of SILAC with the multiplexing of isobaric tags and, in doing so, offers up new opportunities for biological investigation. We applied NeuCode SILAC to examine the relationship between transcript and protein levels in yeast cells responding to environmental stress. Finally, we monitored the time-resolved responses of five signaling mutants in a single 18-plex experiment.
Meta-form near eye visor (2017)

Thesis (Master's)--University of Washington, 2017-06
A Comparison of the Performance of Normal, Learning Disabled, and Educable Mentally Retarded Children on Cattell's Ability Constructs (1980)

The purpose of this investigation was to explore the use of Cattell's ability traits (fluid and crystallized intelligence, visualization, and fluency) as difference characteristics of the learning disabilities category. Previous research and conceptual differences among the learning disabled, normal, and educable mentally retarded populations suggested that learning disabled children would perform better than educable mentally retarded children but not as well as normal children on measures of the traits. Fifteen subjects between the ages of 7 years and 8 years 6 months from each category were administered measures of the traits. An analysis of the scores indicated significant differences between learning disabled and normal children and between learning disabled and educable mentally retarded children on the visualization and fluency measures. Significant differences between the groups were also found on the crystallized intelligence measure but not in fluid intelligence. The results suggest that the crystallized intelligence, visualization, and fluency traits may represent difference characteristics of the learning disabled category, while fluid intelligence may not.
Zeros of Z-transform representation with application to source-filter separation in speech (2005)

We propose a new spectral representation called the zeros of z-transform (ZZT), which is an all-zero representation of the z-transform of the signal. We show that separate patterns exist in ZZT representations of speech signals for the glottal flow and the vocal tract contributions. A decomposition method for source-tract separation is presented based on ZZT. The ZZT-decomposition consists in grouping the zeros into two sets, according to their location in the z-plane. This type of decomposition leads to separating glottal flow contribution (without a return phase) from vocal tract contribution in the z domain.
Forgetting Lenin (1973)

Abstract What is striking in Lenin is that he always speaks the language of the revolutionary technician. The revolution is posed as the end once and for all. It is beyond discussion. The Leninist question "what is to be done?" focuses only on the means and not on the content or the meaning of action. Thus, effectiveness is the main criterion of action. It becomes a question of creating an organization, i.e., of assembling the means and endowing it with maximum effectiveness. Furthermore, organization is not meant to anticipate collective life in the liberated society, but to overthrow existing class domination by better employing its own rules and methods.
TRANSAMINASE ACTIVITY IN HUMAN BLOOD (1955)

Enzymatic transamination consists of the en- zyme catalyzed reversible transfer of the alpha amino nitrogen of an amino acid to an alpha-keto acid with the synthesis of a second amino acid and a second alpha-keto acid. Enzymes catalyzing different transamination reactions are found widely distributed in animal tissues and have been shown to change in activity in some tissues during dis- ease (1-3). These observations prompted the present study to determine if transaminase ac- tivity could be demonstrated in human serum and blood cellular elements and, if so, to study any variations in activity of this enzyme in the blood of normal and diseased man.
LAM-DED Process for Repair and Maintenance of Cast Iron Components using Metallic Powder Alloys (2020)

Laser Additive Manufacturing Directed Energy Deposition (LAM-DED) technology is a promising process for the maintenance and repair of ductile cast iron components. LAM-DED can produce high quality results compared to conventional welding processes. This is due to a narrow and specific heat-affected zone (HAZ) and a strong interface between the base material and filler, caused by reduced heat input with the high energy density. This method also maintains the composition of the clad material in the repair zone and deposits small volumes of filler in specific areas.This paper presents a succinct review of metallic powder alloys as cladding materials for the repair and maintenance of cast iron components. It introduces commercial additive manufacturing (AM) powders used as filler materials for laser cladding of cast iron components, discussing the evolution in microstructure, phase transformation, mechanical properties, and processing issues. This paper summarizes LAM-DED of AM powders for cast iron components and will be a helpful reference for researchers and industry professionals. Key words: LAM-DED process, Laser cladding, Repair & maintenance, Cast iron, AM metal powder
Unraveling the Tapestry of Networks Involving Reactive Oxygen Species in Plants (2008)

The Plant Physiology Special Issue on Reactive Oxygen Species (ROS) published in June 2006 marked the early efforts to resolve the tapestry of mechanisms influenced by ephemeral singlet oxygen, superoxide (O2.−), hydrogen peroxide (H2O2), hydroxyl radical (OH.), peroxynitrite (ONOO−), and nitric
Long Term Survival of Mice with Hepatocellular Carcinoma after Pulse Power Ablation with Nanosecond Pulsed Electric Fields (2012)

Novel therapies are needed for treating hepatocellular carcinoma (HCC) without recurrence in a single procedure. In this work we evaluated anti-neoplastic effects of a pulse power ablation (PPA) with nanosecond pulsed electric fields (nsPEFs), a non-thermal, non-drug, local, regional method and investigated its molecular mechanisms for hepatocellular carcinoma tumor ablation in vivo. An ectopic tumor model was established using C57BL/6 mice with Hepa1-6 hepatocellular carcinoma cells. Pulses with durations of 30 or 100 ns and fast rise times were delivered by a needle or ring electrode with different electric field strengths (33, 50 and 68 kV/cm), and 900 pulses in three treatment sessions (300 pulses each session) or a single 900 pulse treatment. Treated and control tumor volumes were monitored by ultrasound and apoptosis and angiogenesis markers were evaluated by immunohistochemistry. Seventy five percent of primary hepatocellular carcinoma tumors were eradicated with 900 hundred pulses at 100 ns pulses at 68 kV/cm in a single treatment or in three treatment sessions without recurrence within 9 months. Using quantitative analysis, tumors in treated animals showed nsPEF-mediated nuclear condensation (3 h post-pulse), cell shrinkage (1 h), increases in active executioner caspases (caspase-3 > -7 > -6) and terminal deoxynucleotidyl transferase dUTP nick-end-labeling (1 h) with decreases in vascular endothelial growth factor expression (7d) and micro-vessel density (14d). NsPEF ablation eliminated hepatocellular carcinoma tumors by targeting two therapeutic sites, apoptosis induction and inhibition of angiogenesis, both important cancer hallmarks. These data indicate that PPA with nsPEFs is not limited to treating skin cancers and provide a rationale for continuing to investigate pulse power ablation for hepatocellular carcinoma using other models in pre-clinical applications and ultimately in clinical trials. Based on present treatments for specific HCC stages, it is anticipated that nsPEFs could be substituted for or used in combination with ablation therapies using heat, cold or chemicals.
Improving Performance in Digital Forensics: A Case Using Pattern Matching Board (2009)

Due to recent advanced technology in the field of HDD, forensic investigators and analysts are dealing with terabyte data sets and spending tremendous time and effort in forensic investigations. It makes "Speed" one of the hot issues in digital forensics. To get speed up or to improve efficiency, some approaches have been proposed. One of them getting attention is a hardware-based approach. However, such a way is limitedly used in the field of evidence cloning or password cracking while rarely applied in search and analysis for the digital evidence. A general approach to the forensic search is to find specific text strings by comparing every byte of the digital evidence at the physical level. Besides, alternative approaches have been proposed for speedup of search and analysis process. They are usually based on the technologies such like indexing algorithms, distributed processing, and data mining. However, these methods have some drawbacks. Some require a lot of initial time for preprocessing, others are impractical. In order to solve this problem, we have already proposed an efficient and practical approach for forensic analysis in. In this paper, we present the system architecture and show feasibility and scalability of our approach by comparing its performance to those of a popular forensic tool currently on the market.
Glyceryl Tribenzoate: A Flavoring Ingredient, Inhibits the Adoptive Transfer of Experimental Allergic Encephalomyelitis via TGF-β: Implications for Multiple Sclerosis Therapy (2017)

Multiple sclerosis (MS) is the most common autoimmune demyelinating disease of the central nervous system (CNS). Here, we have explored a novel use of glyceryl tribenzoate (GTB), a flavoring ingredient, in ameliorating the disease process of experimental allergic encephalomyelitis (EAE), an animal model of MS, via TGF-β. Oral feeding of GTB suppressed clinical symptoms of adoptively-transferred relapsing-remitting (RR) EAE in recipient mice and suppressed the generation of encephalitogenic T cells in donor mice. GTB also attenuated clinical symptoms of RR-EAE in PLP-TCR transgenic mice and chronic EAE in male C57/BL6 mice. Accordingly, GTB also suppressed perivascular cuffing, preserved the integrity of blood-brain barrier and blood-spinal cord barrier, inhibited inflammation, and stopped demyelination in the CNS of EAE mice. Interestingly, GTB treatment upregulated TGF-β and enriched regulatory T cells (Tregs) in splenocytes as well as <i>in vivo</i> in EAE mice. Blocking TGF-β by neutralizing antibodies abrogated GTB-mediated enrichment of Tregs and protection of EAE. These results suggest that oral GTB may be considered as a possible therapy for MS patients.
Wind power prediction errors model and algorithm based on non-parametric kernel density estimation (2015)

For the high randomness and fluctuation of wind power, as well as the low precision of the power prediction, the traditional prediction of wind power point is not able to describe the uncertainty of wind power. A normal distribution is usually used to model wind power forecast error, but it is not valid in some special cases. In this paper, non-parametric kernel density estimation is adopted to calculate the probability density errors of wind power prediction at different levels. According to system reserve capacity requirements, safety and economy of power generation dispatching, a wind power prediction interval with three spline interpolation is acquired which satisfies the certain confidence interval. The three spline interpolation is the wind power error's distribution function. An equality constrained optimization problem was simplified into an unconstrained optimization problem and Newton with the characteristics of non-parametric kernel was presented. Given a probability value at a certain precision, it's useful to use Newton to search for arguments. Then, the upper and lower range are obtained. The calculation results show that the used wind power interval forecasting method can provide wind power prediction curve and its variation range, and is more suitable for wind power uncertainly.
Identification of intragenic methylation in the TUSC1 gene as a novel prognostic marker of hepatocellular carcinoma (2013)

Patients with hepatocellular carcinoma (HCC) have a poor prognosis, and novel molecular targets for treating recurrence and progression of the disease along with associated biomarkers are urgently required. In the present study, expression and the regulatory mechanism of TUSC1 (tumor suppressor candidate 1) were investigated to determine if it is a candidate tumor suppressor gene for HCC, which shows repressed transcription that involves aberrant DNA methylation. TUSC1 mRNA expression levels in HCC cell lines and 94 pairs of surgical specimens were determined using quantitative real-time reverse transcription polymerase chain reaction assay. Methylation status of HCC cell lines and clinical samples were analyzed to investigate the regulatory mechanism of TUSC1 transcription and the relationship between the methylation status of the TUSC1 gene and clinicopathological factors. The expression and distribution of the TUSC1 protein in liver tissues were determined using immunohistochemistry. A majority of HCC cell lines (89%) and surgical specimens (84%) demonstrated reduced expression levels of TUSC1 mRNA compared with paired non-cancerous liver tissues. The mean mRNA expression level in HCC was significantly lower than in corresponding non-cancerous liver. In contrast, no significant difference was found in TUSC1 mRNA expression level between adjacent normal and cirrhotic liver tissue from HCC patients. The TUSC1 protein expression pattern in HCC and liver tissues was consistent with TUSC1 mRNA expression. Twenty-nine (31%) of 94 patients showed intragenic hypermethylation of the TUSC1 gene in HCC, and hypermethylation was significantly associated with advanced pathological stage. Subsequently, patients with hypermethylation of the TUSC1 gene had a significantly poorer prognosis than patients without hypermethylation. Our results suggest that TUSC1 is a candidate tumor suppressor gene and intragenic hypermethylation is one of the suppressive mechanisms that regulate TUSC1 transcription in HCC. Intragenic methylation of the TUSC1 gene may serve as a novel prognostic marker of HCC.
Hexafluoropropene Oxide — A Key Compound in Organofluorine Chemistry (1985)

Abstract Of the important C 3 ‐compounds in organofluorine chemistry, namely hexafluoropropene, hexafluoroacetone and hexafluoropropene oxide, the latter is chemically the most versatile compound. Hexafluoropropene oxide provides another example of the frequently observed change in reactivity when hydrocarbon compounds are converted into their perfluorinated derivatives. The overwhelming majority of the known reactions of hexafluoropropene oxide are initiated through attack by a nucleophile. The conversion of hexafluoropropene oxide into hexafluoroacetone in the presence of Lewis acids is the basis of further development of the chemistry of this synthetic chemical. Hexafluoropropene oxide is also regarded as a convenient source of difluorocarbene. In industrial chemistry it now plays a significant part in the manufacture of high‐grade organofluorine products.
The Anti-inflammatory and Anti-nociceptive Effects of Ethyl Acetate Fraction of Cynanchi Paniculati Radix (2006)

The anti-inflammatory and anti-nociceptive effects and sedative activities of the ethyl acetate fraction of Cynanchum paniculatum (EACP) were evaluated in mice and rats by acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, cotton pellet-induced granuloma formation, formalin-induced licking time, acetic acid-induced writhing response, and pentobarbital-induced sleeping time. EACP at a dose of 40 mg/kg significantly exhibited anti-inflammatory activities on acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, and the late phase of formalin-induced licking time. Moreover, it showed anti-nociceptive effects on acetic acid-induced writhing responses and significant sedative effects on pentobarbital-induced sleeping time. The results demonstrated that the anti-nociceptive effects are apparently related to the sedative effects of EACP. These results support the use of Cynanchum paniculatum in relieving inflammatory pain.
The Pharmacokinetics of Cell-Penetrating Peptides (2010)

Cell-penetrating peptides (CPPs) are able to penetrate the cell membrane carrying cargoes such as peptides, proteins, oligonucleotides, siRNAs, radioisotopes, liposomes, and nanoparticles. Consequently, many delivery approaches have been developed to use CPPs as tools for drug delivery. However, until now a systematic analysis of their in vivo properties including potential tumor binding specificity for drug targeting purposes has not been conducted. Ten of the most commonly applied CPPs were obtained by solid phase peptide synthesis and labeled with (111)In or (68)Ga. Uptake studies were conducted using a panel of six tumor cell lines of different origin. The stability of the peptides was examined in human serum. Biodistribution experiments were conducted in nude mice bearing human prostate carcinoma. Finally, positron emission tomography (PET) measurements were performed in male Wistar rats. The in vitro uptake studies revealed high cellular uptake values, but no specificity toward any of the cell lines. The biodistribution in PC-3 tumor-bearing nude mice showed a high transient accumulation in well-perfused organs and a rapid clearance from the blood. All of the CPPs revealed a relatively low accumulation rate in the brain. The highest uptake values were observed in the liver (with a maximal uptake of 51 %ID/g observed for oligoarginine (R(9))) and the kidneys (with a maximal uptake of 94 %ID/g observed for NLS). The uptake values in the PC-3 tumor were low at all time points, indicating a lack of tumor specific accumulation for all peptides studied. A micro-PET imaging study with (68)Ga-labeled penetratin, Tat and transportan(10) (TP(10)) confirmed the organ distribution data. These data reveal that CPPs do not show evidence for application in tumor targeting purposes in vivo. However, CPPs readily penetrate into most organs and show rapid clearance from the circulation. The high uptake rates observed in vitro and the relatively low specificity in vivo imply that CPPs would be better suited for topical application in combination with cargoes which show passive targeting and dominate the pharmacokinetic behavior. In conclusion, CPPs are suitable as drug carriers for in vivo application provided that their pharmacokinetic properties are also considered in design of CPP drug delivery systems.
Tipping v. Roberts, 1704–1733 (1992)

This chapter presents a case study on bigamous marriage in England, focusing on the court case Tipping v. Roberts which was decided in 1733. The case involved Robert Tipping, Sarah Roberts, and Elizabeth Hughes. Robert married Sarah in 1704 and they had several children. He left her in 1714 to marry Elizabeth. Sarah filed a suit to force Robert to settle a maintenance allowance to support herself and her children. Robert settled out of court and provided what Sarah demanded. Sarah again filed for support and this time Robert only agreed on the condition that Sarah would sign a document denouncing any further claims on Robert. This was the de facto equivalent of a divorce settlement.
Twenty Tips for Developing 20/20 Vision for Businesses (1993)

Describes the author′s concept of 20/20 vision in business and the practice of “20/20 Realities” as a means of anticipating coming changes in the information economy.
A CASE OF SCHISTOSOMAL APPENDICITIS (1997)

Acute appendicitis is a great masquerader in surgical practice; its diverse clinical presentation can sometimes lead to delay in diagnosis. Nonetheless, the underlying aetiology of acute appendicitis may not be apparent if the appendix is not sent for histological examination.