gebhart/patrepeval huggingface dataset:
A Key Role for Orphan Nuclear Receptor Liver Receptor Homologue-1 in Activation of Fatty Acid Synthase Promoter by Liver X Receptor (2007)

Liver X receptor (LXR) activates fatty acid synthase (FAS) gene expression through binding to a DR-4 element in the promoter. We show that a distinct nuclear receptor half-site 21 bases downstream of the DR-4 element is also critical for the response of FAS to LXR but is not involved in LXR binding to DNA. This half-site specifically binds liver receptor homologue-1 (LRH-1) in vitro and in vivo, and we show LRH-1 is required for maximal LXR responsiveness of the endogenous FAS gene as well as from promoter reporter constructs. We also demonstrate that LRH-1 stimulation of the FAS LXR response is blocked by the addition of small heterodimer partner (SHP) and that FAS mRNA is overexpressed in SHP knock-out animals, providing evidence that FAS is an in vivo target of SHP repression. Taken together, these findings identify the first direct lipogenic gene target of LRH-1/SHP repression and provide a mechanistic explanation for bile acid repression of FAS and lipogenesis recently reported by others.
Three dimensional printing of components and functional devices for energy and environmental applications (2017)

Recent advances regarding the implementation of 3D printing for solid oxide fuel cells, batteries, solar energy and environmental applications are reviewed.
A 10MHz to 315MHz cascaded hybrid PLL with piecewise linear calibrated TDC (2009)

An ADPLL with a piecewise linear calibrated hierarchical TDC is proposed to achieve a wide range of operation and a CPPLL is cascaded to filter out 1/f noise. A phase selectable divider is also proposed to divide the clock frequency while keeping the relative phase difference of output same as that of input. The cascaded hybrid PLL fabricated in 65 nm CMOS process burns 17 mW and occupies 0.4 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The measured jitters are 1.1 ns <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> and 223.6 ps <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> , respectively with a multiplication factor of 1,024.
Components of the Site-specific Recombination System Encoded by the Yeast Plasmid 2-Micron Circle (1984)

Site-specific recombination events have been documented in both prokaryotic and eukaryotic cells and in most cases the rearrangements resulting from these events have profound consequences for the biology of the organism. As an approach to evaluating the mechanism of such recombination events in a eukaryotic cell, we are examining the specialized recombination system encoded by the 2-micron circle plasmid present in the yeast Saccharomyces.
A plasmid in Streptococcus pneumoniae (1979)

Plasmid deoxyribonucleic acid has been detected in three related laboratory strains of Streptococcus pneumoniae. Strains D39S, R36, and R36NC each contain a minimum of two copies per cell of a 2.0-megadalton plasmid (pDP1). A plasmid twice as large as this smaller one is also present in much lower quantity in these strains, but neither plasmid is present in four strains related to these or in a drug-resistant clinical isolate from Paris. The plasmid yield was not amplified in the presence of chloramphenicol. No phenotype has been correlated with the presence of pDP1, which has existed in strains carried for many years in laboratory collections.
Continuous electroreduction of CO<sub>2</sub> to formate using Sn gas diffusion electrodes (2014)

Electrochemical valorization may be a strategy for mitigating climate change, as the process allows for CO 2 to be converted into industrially useful chemicals. The aim of this work is to study the influence of key variables on the performance of an experimental system for continuous electroreduction of CO 2 to formate with a gas diffusion electrode (GDE) loaded with Sn. A 2 3 factorial design of experiments at different levels of current density (j), electrolyte flow rate/electrode area ratio (Q/A ratio) and GDE Sn load was followed. Higher rates and concentrations (i.e., 1.4·10 −3 mol m −2 s −1 and 1348 mg L −1 with efficiencies of approximately 70%) were obtained with GDEs than with plate electrodes. The statistical design of experiments demonstrated that the Sn load had the most significant effect on rate and efficiency. However, despite these promising results, further research is required to optimize the process. © 2014 American Institute of Chemical Engineers AIChE J , 60: 3557–3564, 2014
Spatial and temporal variation patterns of reference evapotranspiration across the Qinghai‐Tibetan Plateau during 1971–2004 (2009)

Reference evapotranspiration (RET), an indicator of atmospheric evaporating capability over a hypothetical reference surface, was calculated using the Penman‐Monteith method for 75 stations across the Qinghai‐Tibetan Plateau between 1971 and 2004. Generally, both annual and seasonal RET decreased for most part of the plateau during the study period. Multivariate linear models were used to determine the contributions of climate factors to RET change, including air temperature, air humidity, solar radiation, and wind speed. Spatial differences in the causes of RET change were detected by K‐means clustering analysis. It indicates that wind speed predominated the changes of RET almost throughout the year, especially in the north of the study region, whereas radiation was the leading factor in the southeast, especially during the summertime. Although the recent warming trend over the plateau would have increased RET, the combined effect of the reduced wind speed and shortened sunshine duration negated the effect of rising temperature and caused RET to decrease in general. The significant decrease in surface wind speed corresponded to the decreasing trends of upper‐air zonal wind and the decline of pressure gradient, possibly as a result of the recent warming.
Gene Therapy Applications (2011)

The aim of our book is to provide a detailed discussion of gene therapy application in human diseases. The book brings together major approaches: (1) Gene therapy in blood and vascular system, (2) Gene therapy in orthopedics, (3) Gene therapy in genitourinary system, (4) Gene therapy in other diseases. This source will make clinicians and researchers comfortable with the potential and problems of gene therapy application.
An investigation into the efficiency of disposable face masks. (1980)

Disposable face masks used in hospitals have been assessed for the protection afforded the patient and the wearer by challenges of simulated natural conditions of stress. Operating theatre masks made of synthetic materials allow the wearer to breathe through the masks, and these have been shown to protect the patient well but the wearer slightly less. Cheaper paper masks are worn for ward duties, and of these only the Promask protected in area in front of the wearer: air does not pass through this mask, expired air is prevented from passing forward, and the wearer breathes unfiltered air. All the other paper masks tested allowed many bacteria-laden particles to pass through them.
Data Mining and Diagnosing IC Fails (2005)

This book grew out of an attempt to describe a variety of tools that were developed over a period of years in IBM to analyze Integrated Circuit fail data. The selection presented in this book focuses
A DESIGN OF MULTIBAND, DUAL-POLARIZATION, BEAM-SWITCHABLE DUAL-ANTENNA FOR INDOOR BASE STATIONS (2014)

A novel multiband, dual-polarization, beam-switched dual-antenna design, covering some LTE and WLAN bands, has been proposed for indoor base stations. The proposed design consists mainly of dual modified monopole antennas. The horizontal antenna consists of four printed monopole elements, and the control circuit using p-i-n diodes has been implemented for feeding to each monopole element. The vertical monopole antenna beam patterns are controlled by reconfigurable frequency selective reflectors (RFSR) technique. The p-i-n diodes have been utilized for switching mechanism to feed the four RFSR. The measured and simulated results indicate that the antenna system possesses multiband and dual polarization. It has been observed from the simulated and measured reflection coefficients |S 11 | that the presented dual antenna system supports both LTE (1.7-2.1 GHz) and WLAN (2.5 GHz and 5.8 GHz) band frequencies. Moreover, the radiation characteristics show dual-polarization behaviors of the presented antenna system and beam switching states suitable for small cell indoor-base stations.
Zn(II)-Coordinated Quantum Dot-FRET Nanosensors for the Detection of Protein Kinase Activity (2015)

We report a simple detection of protein kinase activity using Zn(II)-mediated fluorescent resonance energy transfer (FRET) between quantum dots (QDs) and dye-tethered peptides. With neither complex chemical ligands nor surface modification of QDs, Zn(II) was the only metal ion that enabled the phosphorylated peptides to be strongly attached on the carboxyl groups of the QD surface via metal coordination, thus leading to a significant FRET efficiency. As a result, protein kinase activity in intermixed solution was efficiently detected by QD-FRET via Zn(II) coordination, especially when the peptide substrate was combined with affinity-based purification. We also found that mono- and di-phosphorylation in the peptide substrate could be discriminated by the Zn(II)-mediated QD-FRET. Our approach is expected to find applications for studying physiological function and signal transduction with respect to protein kinase activity.
Schaum's outline of fluid mechanics and hydraulics (2009)

Tough Test Questions? Missed Lectures? Not Enough Time? Fortunately, there's Schaum's. More than 40 million students have trusted Schaum's to help them succeed in the classroom and on exams. Schaum's is the key to faster learning and higher grades in every subject. Each Outline presents all the essential course information in an easy-to-follow, topic-by-topic format. You also get hundreds of examples, solved problems, and practice exercises to test your skills. This Schaum's Outline gives you: 622 fully solved problems; extra practice on topics such as buoyancy and flotation, complex pipeline systems, fluid machinery, flow in open channels, and more; and support for all the major textbooks for fluidmechanics and hydraulics courses. Fully compatible with your classroom text, Schaum's highlights all the important facts you need to know. Use Schaum's to shorten your study time - and get your best test scores! Schaum's Outlines - Problem Solved.
Reactions of Heterodinuclear .mu.-Ethynediyl Palladium-Platinum Complexes with Isocyanides: Living Polymerization of Aryl Isocyanides (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Heterodinuclear .mu.-Ethynediyl Palladium-Platinum Complexes with Isocyanides: Living Polymerization of Aryl IsocyanidesKiyotaka Onitsuka, Koichi Yanai, Fumie Takei, Takashi Joh, and Shigetoshi TakahashiCite this: Organometallics 1994, 13, 10, 3862–3867Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/om00022a022https://doi.org/10.1021/om00022a022research-articleACS PublicationsRequest reuse permissionsArticle Views500Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modeling Web Site Structure in UriGraph. (2003)

This paper introduces a Web site structure model called UriGraph and, using the model, describes several important patterns of site structure. Web site structure is defined as the collective information about the identity, identifier, position and composition of every resource constituting the Web site. UriGraph models the site&apos;s resource identifiers and through them the resource identity and composition, and indirectly the resource position. UriGraph is designed specifically for the Web and it is compatible with the current practice. It can be represented graphically and as an XML document.
1. The Image of Nietzsche (2001)

Abstract Friedrich Nietzsche (1844–1900) was a German philosopher, almost wholly neglected during his sane life. ‘The Image of Nietzsche’ highlights the immense impact of his work after his death. Poor English translations of Nietzsche's writings resulted in a misrepresentation of his thinking. In 1950, Walter Kaufmann began retranslating his key works and unveiled a more traditional thinker than previously thought. Kaufmann sought to establish comprehensively his remoteness from the Nazis, from all irrationalist movements that had claimed him as their forebear, and from Romanticism in the arts. Nietzsche's work has proved so attractive to such diverse movements and schools of thought partly due to the witty and radical content of his aphorisms.
A Hybrid Method of Hiding The Text Information Using Stegnography (2013)

The Often Distribution of encrypted messages will depict the concentration of third parties. The attempts can be made to break and expose the actual messages by the hackers and cracker crackers. To conceal the subsistence of message steganography is introduced by hiding a secret message inside another credulous message.Steganography along with cryptograph y is used and offers suitable amount of privacy and security over the communication cha channel. nnel. In this paper along with various existing text text-based steganography techniques, an overview of text steganography and a concise history of steganography can be presented. The problems present in the text steganography and issues with existing solution solutionss are highlighted. In information hiding, a novel approach is proposed by using inter-word word spacing and inter inter-paragraph paragraph spacing as a hybrid method. Based on the length of the secret message, the proposed method provides dynamic generated stego stego-text with six ix options of maximum capacity. The considerable drawbacks of every existing method and how our new approach might be recommended as a solution can be analyzed in this paper.
P-127 (2012)

Castillo, Ricardo; Resnick, Carol; Frisancho, Augusto; Silbergeld, Ellen; Feingold, Beth Author Information
Characteristics Verification of an Independently Controllable Electromagnetic Spherical Motor (2014)

We have been developing electromagnetic spherical actuators capable of three-degree-of-freedom rotation. However, these actuators require complex control to realize simultaneous triaxial drive, because rotation around one axis interferes with rotation around another. In this paper, we propose a new three-degree-of-freedom actuator where 3-axes rotation can be controlled easily. The basic structure and the operating principle of the actuator are described. Then the torque characteristics and the dynamic characteristics are computed by employing 3D-FEM and the effectiveness of this actuator is clarified. Finally, the experimental results using the prototype of the actuator are shown to verify the dynamic performance.
Stabilization of glucose-6-phosphatase activity by a 21 000-dalton hepatic microsomal protein (1985)

Hepatic microsomal glucose-6-phosphatase activity was rendered extremely unstable by a variety of techniques: (a) incubation at pH 5.0; (b) extraction of the microsomal fraction in the presence of 1% Lubrol; (c) various purification procedures. These techniques all result in the removal of a 21 kDa polypeptide from the fraction containing glucose-6-phosphatase activity. The 21 kDa protein was purified to apparent homogeneity by solubilization in the detergent Lubrol 12A-9 and chromatography on Fractogel TSK DEAE-650(S) and centrifugation at 105 000 g. The 21 kDa protein stabilizes glucose-6-phosphatase activity, whereas other purified hepatic microsomal proteins do not. The 21 kDa protein appears to be a potential regulator of glucose-6-phosphatase activity.
Metabolically normal obese people are protected from adverse effects following weight gain (2015)

BACKGROUND. Obesity is associated with insulin resistance and increased intrahepatic triglyceride (IHTG) content, both of which are key risk factors for diabetes and cardiovascular disease. However, a subset of obese people does not develop these metabolic complications. Here, we tested the hypothesis that people defined by IHTG content and insulin sensitivity as "metabolically normal obese" (MNO), but not those defined as "metabolically abnormal obese" (MAO), are protected from the adverse metabolic effects of weight gain. METHODS. Body composition, multiorgan insulin sensitivity, VLDL apolipoprotein B100 (apoB100) kinetics, and global transcriptional profile in adipose tissue were evaluated before and after moderate (~6%) weight gain in MNO (n = 12) and MAO (n = 8) subjects with a mean BMI of 36 ± 4 kg/m2 who were matched for BMI and fat mass. RESULTS. Although the increase in body weight and fat mass was the same in both groups, hepatic, skeletal muscle, and adipose tissue insulin sensitivity deteriorated, and VLDL apoB100 concentrations and secretion rates increased in MAO, but not MNO, subjects. Moreover, biological pathways and genes associated with adipose tissue lipogenesis increased in MNO, but not MAO, subjects. CONCLUSIONS. These data demonstrate that MNO people are resistant, whereas MAO people are predisposed, to the adverse metabolic effects of moderate weight gain and that increased adipose tissue capacity for lipogenesis might help protect MNO people from weight gain-induced metabolic dysfunction. TRIAL REGISTRATION. ClinicalTrials.gov NCT01184170. FUNDING. This work was supported by NIH grants UL1 RR024992 (Clinical Translational Science Award), DK 56341 (Nutrition and Obesity Research Center), DK 37948 and DK 20579 (Diabetes Center Grant), and UL1 TR000450 (KL2 Award); a Central Society for Clinical and Translational Research Early Career Development Award; and by grants from the Longer Life Foundation and the Kilo Foundation.
Single stage cell seeding of small diameter prosthetic cardiovascular grafts. (2005)

Small-diameter prosthetic cardiovascular bypass grafts have high occlusion rates. Thrombogenicity caused by the lack of endothelial cells (ECs) on the luminal surface of the grafts is one of the main reasons for its occlusion. One strategy to improve the clinical performance of cardiovascular prosthetic grafts has been to seed its luminal surface with a monolayer of the patient's own ECs. In this strategy a "two stage" seeding procedure is utilized whereby cells obtained from a vein are amplified in cell culture, then seeded onto a fibrin-arginine-glycine-aspartate (RGD) tripeptide-enriched expanded polytetrafluoroethylene (ePTFE) graft in a rotating bioreactor for one week, after which it is surgically implanted. This achieves patency rates approaching those of vein grafts. The disadvantage of two stage seeding is that it requires culture facilities, a large amount of RGD, which is expensive and is confined to elective cases because of the delay between cell cultivation, seeding, and graft implantation. A single stage seeding using freshly extracted ECs that is transplanted onto the graft at the same time frame of the bypass operation without the need for cell cultivation would be an ideal answer for the disadvantages of two stage seeding. Animal trials have been successful but human trials of single stage seeding have been disappointing. It has been hypothesized that extracted ECs are scarce, furthermore, they are washed off the graft surface once exposed to blood flow. This review examines the various techniques/technologies to improve endothelial cell extraction from various sources and retention onto the luminal surface of prosthetic cardiovascular grafts in order to develop a clinically applicable strategy for single stage seeding.
Learning dictionaries for local sparse coding in image classification (2011)

Low dimensional embedding of data samples lying on a manifold can be performed using locally linear modeling. By incorporating suitable locality constraints, sparse coding can be adapted to modeling local regions of a manifold. This has been coupled with the spatial pyramid matching algorithm to achieve state-of-the-art performance in object recognition. In this paper, we propose an algorithm to learn dictionaries for computing local sparse codes of descriptors extracted from image patches. The algorithm iterates between a local sparse coding step and an update step that searches for a better dictionary. Evaluation of the local sparse code for a data sample is simplified by first estimating its neighbors using the proposed distance metric and then computing the minimum ℓ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> solution using only the neighbors. The proposed dictionary update ensures that the neighborhood of a training sample is not changed from one iteration to the next. Simulation results demonstrate that the sparse codes computed using the proposed dictionary achieve improved classification accuracies when compared to using a K-means dictionary with standard image datasets.
Reconfigurable matched bandstop filter (2011)

This paper demonstrates a reconfigurable matched bandstop filter. The filter is based on a lossy allpass network. The lossy allpass network demonstrates the concept and design of perfectly matched bandstop response with a perfect matched at all frequencies. The filter is based on the half-wavelength λ over 2 resonator with gap coupling, parallel with an allpass nominally-90°-phase-shift element, which can be optimized to achieve high Q-factor. The reconfigurable matched bandstop filter can be realized by using PIN diodes as a switching element. This filter provides two state of operation under two conditions. The first condition is that the filter will produce allpass response when the PIN diodes are turned `ON'. The second condition is that the filter will produce bandstop response when the PIN diodes are turned `OFF'. Theoretical analysis together with experimental results is presented in this paper.
Parliament and Public Money: Players and Police (2005)

This paper begins from the premise that until Parliament increases its ability to influence the Estimates and the supply process, real scrutiny and accountability of government will be impossible. It reviews the record of frustration for parliamentarians in the scrutiny of the Estimates and suggests some reforms that might allow parliamentarians a greater role in this area.