gebhart/patrepeval huggingface dataset:
Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1 (1998)

Neurofibromatosis type 1 (NF1) is a common familial tumour syndrome with multiple clinical features such as neurofibromas, café-au-lait spots (CLS), iris Lisch nodules, axillary freckling, optic glioma, specific bone lesions and an increased risk of malignant tumours. It is caused by a wide spectrum of mutations affecting the NF1 gene. Most mutations result in the loss of one allele at the DNA, mRNA or protein level and thus in the loss of any function of the gene product neurofibromin. The idea of the simultaneous loss of several different neurofibromin functions has been postulated to explain the pleiotropic effects of its loss. However, we have identified a novel missense mutation in a family with a classical multi-symptomatic NF1 phenotype, including a malignant schwannoma, that specifically abolishes the Ras-GTPase-activating function of neurofibromin. In this family, Arg1276 had mutated into proline. Based on complex biochemical studies as well as the analysis of the crystal structure of the GTPase-activating protein (GAP) domain of p120GAP in the presence of Ras, we unequivocally identified this amino acid as the arginine finger of the neurofibromin GAP-related domain (GRD)-the most essential catalytic element for RasGAP activity. Here, we present data demonstrating that the mutation R1276P, unlike previously reported missense mutations of the GRD region, does not impair the secondary and tertiary protein structure. It neither reduces the level of cellular neurofibromin nor influences its binding to Ras substantially, but it does completely disable GAP activity. Our findings provide direct evidence that failure of neurofibromin GAP activity is the critical element of NF1 pathogenesis. Thus, therapeutic approaches aimed at the reduction of Ras.GTP levels in neural crest-derived cells can be expected to relieve most of the NF1 symptoms.
Very low loss ultrathin Co-based amorphous ribbon cores (1988)

Ultrathin Co-based amorphous ribbons with a thickness of 6–10 μm were fabricated by a single roller quenching method in vacuum. The compositions of the alloys were zero magnetostrictive: Fe4.7Co70.3Si15B10 and (Fe0.05Co0.95)71(Si0.5B0.5)29. The ribbons obtained had good smoothness and dimensional uniformity. The core loss of toroidal samples 15 mm in diameter was measured after annealing. The loss decreased with decreasing ribbon thickness. In the case of 6.4-μm-thick (Fe,Co)71(Si,B)29 amorphous ribbon, the values at 100 kHz and 1 MHz were 40 mW/cm3 and 1.8 W/cm3 for Bm=0.1 T, respectively. The former was 1/4 that of Mn-Zn ferrites or 1/2 that of 5-μm-thick Supermalloy tape wound core loss. The latter was (2)/(3) that of 5-μm Supermalloy tape wound core loss. In addition, the initial permeability beyond 100 kHz was also markedly improved by thickness reduction. The values of 6.4-μm-thick (Fe,Co)71(Si,B)29 ribbon measured at 1 and 10 MHz were about 7000 and 1000 for Hm=2 mOe, respectively.
Optimizing the Web Cache Performance by Clustering based Pre-Fetching Technique using Modified ART1 (2012)

Web caching is a technique which is used to reduce user perceived latency when user is accessing the Web pages. Web pre-fetching is a scheme where Web pages are pre-fetched into the intermediate server (proxy) cache before user accessing it. These two techniques can complement each other since the Web caching exploits the temporal locality, whereas Web pre-fetching utilizes the spatial locality of Web objects. In this paper, we developed modified ART1 neural network to pre-fetch Web pages into the proxy cache. We have also empirically shown the performance of proposed work with the existing ART1 based pre-fetching. By using this approach the hit rate of the cache increases, which in turn reduces the user perceived latencies.
[Exploration for building PACS and RIS]. (2006)

This article elaborates key points of the PACS and RIS project: its overall planning, implementation step by step, integration of PACS and HIS based on IHE, and the prudent selection of partners and so on.
Interrelationship of Repair Mechanisms in Ultraviolet-Irradiated <i>Escherichia coli</i> (1974)

Investigation of the effect of photoreactivation, excision, and recombination repair, individually and in combination, on the survival of ultraviolet-irradiated Escherichia coli K-12 mutants has led to a possible explanation of the loss of photoreactivability and of the complex changes in viability observed during liquid-holding. It is suggested that at higher ultraviolet light doses the excision repair mechanism becomes saturated due to overlapping of excised regions on opposite strands of the deoxyribonucleic acid helix. The results also provide support for the existing hypothesis that states that the shape of shouldered survival curves of ultraviolet-irradiated bacteria can be described in terms of the probability of occurrance of overlapping excised regions. Using the data obtained with repair-deficient mutants with closely related genetic makeup, we present a mathematical model that accurately predicts the shape of the observed survival curves and provides an estimate of the number of nucleotides in each fragment of deoxyribonucleic acid removed by the excision repair mechanism.
Chapter 6: Steady state operation (2007)

Significant progress has been made in the area of advanced modes of operation that are candidates for achieving steady state conditions in a fusion reactor. The corresponding parameters, domain of operation, scenarios and integration issues of advanced scenarios are discussed in this chapter. A review of the presently developed scenarios, including discussions on operational space, is given. Significant progress has been made in the domain of heating and current drive in recent years, especially in the domain of off-axis current drive, which is essential for the achievement of the required current profile. The actuators for heating and current drive that are necessary to produce and control the advanced tokamak discharges are discussed, including modelling and predictions for ITER. The specific control issues for steady state operation are discussed, including the already existing experimental results as well as the various strategies and needs (qψ profile control and temperature gradients). Achievable parameters for the ITER steady state and hybrid scenarios with foreseen heating and current drive systems are discussed using modelling including actuators, allowing an assessment of achievable current profiles. Finally, a summary is given in the last section including outstanding issues and recommendations for further research and development.
Antisense to the Epstein-Barr Virus (EBV)-Encoded Latent Membrane Protein 1 (LMP-1) Suppresses LMP-1 and Bcl-2 Expression and Promotes Apoptosis in EBV-Immortalized B Cells (1998)

The Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP-1) is required for viral transformation and functions to protect cells from apoptotic cell death, in part, by induction of antiapoptotic genes, including Bcl-2 and A20. We have used antisense oligodeoxynucleotides targeted to LMP-1 as a strategy to suppress LMP-1 expression and thereby inhibit its functions. We have shown that levels of LMP-1 protein in EBV-positive lymphoblastoid cell lines can be reduced by in vitro treatment with unmodified oligodeoxynucleotides targeted to the first five codons of the LMP-1 open-reading frame. Furthermore, suppression of LMP-1 was associated with molecular and phenotypic effects that included downregulation of the LMP-1–inducible antiapoptotic genes, Bcl-2 and Mcl-1, inhibition of proliferation, stimulation of apoptosis, and enhancement of sensitivity to the chemotherapeutic agent, etoposide. These effects were largely sequence-specific and observed in EBV-positive, but not EBV-negative cell lines. These studies suggest that lowering expression of LMP-1 in EBV-associated malignancy might have therapeutic effects and might synergize with other antitumor agents. © 1998 by The American Society of Hematology.
Skin-mountable stretch sensor for wearable health monitoring (2016)

This work presents a wrinkled Platinum (wPt) strain sensor with tunable strain sensitivity for applications in wearable health monitoring. These stretchable sensors show a dynamic range of up to 185% strain and gauge factor (GF) of 42. This is believed to be the highest reported GF of any metal thin film strain sensor over a physiologically relevant dynamic range to date. Importantly, sensitivity and dynamic range are tunable to the application by adjusting wPt film thickness. Performance is reliable over 1000 cycles with low hysteresis after sensor conditioning. The possibility of using such a sensor for real-time respiratory monitoring by measuring chest wall displacement and correlating with lung volume is demonstrated.
A novel Brn3-Iike POU transcription factor expressed in subsets of rat sensory and spinal cord neurons (1993)

Brn3a and Brn3b are mammalian members of the POU class of transcription factors. They are closely related to each other and to Unc86, which determines the normal development of certain cells, including mechanoreceptive sensory neurons in Caenorhabditis elegans. We screened a rat dorsal root ganglion (DRG) cDNA library at moderate stringency with a Brn3a POU-domain probe and identified a novel transcript encoding a POU protein that we have named Brn3c. Brn3c closely resembles Brn3a and Brn3b in its POU-domain and thus helps define a family of Unc86-related mammalian POU factors. Both Brn3a and Brn3c are expressed only in the central and peripheral nervous systems. In the neonatal rat, northern blots revealed a 3.6 kb Brn3a transcript in DRG, spinal cord and hindbrain, and a 2.6 kb Brn3c transcript in DRG and spinal cord. In situ hybridization showed that most DRG neurons express Brn3a whereas only a small subset of neurons expresses Brn3c. In the spinal cord, Brn3a is expressed by many dorsal horn neurons. In contrast, Brn3c is expressed by a very small number of cells in laminae 4/5 of the dorsal horn. These data suggest that Brn3-related POU factors may be involved in the development or function of particular subclasses of sensory and spinal cord neurons.
Invited Article: High resolution digital camera for infrared reflectography (2009)

This paper describes the characteristics of a high resolution infrared (IR) imaging system operating over the wavelength range of 830–1100 nm, based on a modified 8 Mpixels commercial digital camera, with which nonspecialists can obtain IR reflectograms of works of art in situ in a museum environment. The relevant imaging properties of sensitivity, resolution, noise, and contrast are characterized and the capabilities of this system are illustrated with an example that has revealed important new information about the working practices of a 16th century artist.
Effect of Cromolyn on S100P Interactions With RAGE and Pancreatic Cancer Growth and Invasion in Mouse Models (2006)

Cromolyn binds S100P, prevents activation of RAGE, inhibits tumor growth, and increases the effectiveness of gemcitabine in experimental models.
Identification and physical mapping of a polymorphic human T cell receptor V beta gene with a frequent null allele. (1993)

Germline variation in genes that encode the human T cell receptors (TCRs) may have an important influence in shaping the immune T cell repertoire. In this report we describe a frequent null allele of the human V beta 18 gene, resulting from a nucleotide substitution that creates a stop codon (CGA<-->TGA). Approximately 11% of the population tested was homozygous for this null allele, indicating that this is a frequent "hole in the repertoire." We confirmed that there is a greatly reduced (undetectable) level of V beta 18 mRNA in peripheral blood lymphocytes from an individual homozygous for this null allele. In addition, all heterozygous individuals expressed detectable levels of only the functional V beta 18 allele in their peripheral blood lymphocytes. Two other DNA polymorphisms were identified in V beta 18, one of which would result in an amino acid substitution in an expressed V beta 18 gene. Genotypes for all three of these V beta 18 DNA polymorphisms were determined in a group of unrelated individuals. Statistical analyses of the associations between alleles of the V beta 18 polymorphisms and those of other DNA polymorphisms in the TCR beta locus suggested a close physical proximity between the V beta 18 gene and the 3' end of the C beta 2 region. This localization of human V beta 18 had been previously predicted by the sequence homology between human V beta 18 and mouse V beta 14, a V gene segment previously mapped to 3' of the mouse C beta genes. We confirmed this localization of the human V beta 18 gene by isolating a cosmid clone that contains both the V beta 18 and C beta 2 segments. Mapping by restriction enzyme digestion and by the polymerase chain reaction indicated that the V beta 18 gene segment is approximately 9 kb 3' of the C beta 2 gene, making this the only known human V beta gene 3' of the C beta region.
Kinetics of the oxidation of hydrazine by hydrogen peroxide, catalyzed by hydrated copper(II) (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of the oxidation of hydrazine by hydrogen peroxide, catalyzed by hydrated copper(II)Carl R. Wellman, J. Richard Ward, and Lester P. KuhnCite this: J. Am. Chem. Soc. 1976, 98, 7, 1683–1684Publication Date (Print):March 1, 1976Publication History Published online1 May 2002Published inissue 1 March 1976https://pubs.acs.org/doi/10.1021/ja00423a008https://doi.org/10.1021/ja00423a008research-articleACS PublicationsRequest reuse permissionsArticle Views1210Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fringe pattern analysis using hybrid image processing (1990)

Hybrid image processing using optical defocusing and digital computing techniques is investigated for use in the analysis of interferograms or moire fringes. The optical thickness distribution of a glass plate is measured from the interferogram, and the power distribution of an eyeglass lens is tested from the moire pattern. The optical defocusing technique is also used for preprocessing of the input image to suppress high frequency noises. The optimum defocus amount relating to the processed result is discussed.
Transforming Growth Factor‐β Effect on Soft Tissue Repair (1990)

Previous studies have demonstrated that TGF-beta possesses many of the biologic properties necessary for acceleration of the normal wound healing process. We report that recombinant human TGF-beta 2 (rhuTGF-beta 1) increases wound strength and accelerates wound closure when applied topically to experimental wounds. Doses of 5 to 1,000 ng/wound increased wound strength in a dose-response manner and wound strength increase as high as 161% above control in the rat incisional wound model. Increased wound strength was observed as early as 3 days following rhuTGF-beta 1 application and continued to Day 28. In the rabbit ear ulcer model, acceleration of wound closure was observed following doses of 5 to 100 ng/wound applied a single topical application. No adverse effects of rhuTGF-beta 1 were observed. The amount of fibrous tissue, scar formation, and mitotic figures were not significantly greater than control. Epithelialization of rhuTGF-beta 1-treated wounds was not impeded. rhuTGF-beta 1 induced bone formation in the rabbit ear ulcer model but not in the rat incisional model, suggesting that precursor cells, such as perichondrial cells, are required for the bone forming activities of TGF-beta 1.
Some Metal Complexes of Schiff Base Ligands Derived from Ninhydrin and Some Amino Acids (1997)

Abstract The Fe(III), Cr(III) and Al(III) complexes of Schiff base ligands derived from ninhydrin with some amino acids (glycine, α-alanine, serine) have been prepared and characterized by means of elemental analyses, IR, electronic spectra as well as conductivity and magnetic measurements. Modes of bonding and geometrical structures for these chelates are proposed.
Metadata for integrating speech documents in a text retrieval system (1994)

We present an information retrieval system that simultaneously allows to search for text and speech documents. The retrieval system accepts vague queries and performs a best-match search to find those documents that are relevant to the query. The output of the retrieval system is a list of ranked documents where the documents on the top of the list satisfy best the user's information need. The relevance of the documents is estimated by means of metadata (document description vectors). The metadata is automatically generated and it is organized such that queries can be processed efficiently. We introduce a controlled indexing vocabulary for both speech and text documents. The size of the new indexing vocabulary is small (1000 features) compared with the sizes of indexing vocabularies of conventional text retrieval (10000 - 100000 features). We show that the retrieval effectiveness based on such a small indexing vocabulary is similar to the retrieval effectiveness of a Boolean retrieval system.
Syphilis in Renaissance Europe: rapid evolution of an introduced sexually transmitted disease? (2004)

When syphilis first appeared in Europe in 1495, it was an acute and extremely unpleasant disease. After only a few years it was less severe than it once was, and it changed over the next 50 years into a milder, chronic disease. The severe early symptoms may have been the result of the disease being introduced into a new host population without any resistance mechanisms, but the change in virulence is most likely to have happened because of selection favouring milder strains of the pathogen. The symptoms of the virulent early disease were both debilitating and obvious to potential sexual partners of the infected, and strains that caused less obvious or painful symptoms would have enjoyed a higher transmission rate.
Study of the fluxing agent effects on the properties of no-flow underfill materials for flip-chip applications (1999)

As one of the key requirements of the no-flow underfill materials for flip-chip applications, a proper self-fluxing agent must be incorporated in the developed no-flow underfill materials to provide proper fluxing activity during the simultaneous solder reflow and underfill material curing. However, most fluxing agents have some adverse effects on the no-flow underfill material properties and assembly reliability. In this paper, we have extensively investigated the effects of the concentration of the selected fluxing agent on the material properties, interconnect integrity and assembly reliability. Through this work, an optimum concentration window of the fluxing agent is obtained and a routine procedure of evaluating fluxing agents is established.
Fluorescence polarization studies of the self-association of beef liver glutamate dehydrogenase (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorescence polarization studies of the self-association of beef liver glutamate dehydrogenaseDean A. Malencik and Sonia R. AndersonCite this: Biochemistry 1972, 11, 16, 3022–3027Publication Date (Print):August 1, 1972Publication History Published online1 May 2002Published inissue 1 August 1972https://pubs.acs.org/doi/10.1021/bi00766a014https://doi.org/10.1021/bi00766a014research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The effect of defects on the electronic and magnetic properties of Fe<sub>2</sub>MnSi Heusler alloy (2011)

Abstract Density functional theory (DFT) calculations were performed by using FP‐LAPW method to investigate the effect of defects on the electronic and magnetic structure of Fe 2 MnSi Heusler alloy. The formation energies were calculated for antisite, swap, and vacancy defects. We found that three defects, namely Mn Fe and Mn Si antisite as well as Fe–Mn swap defects may spontaneously occur as they have negative formation energies. Whereas, Mn and Si vacancies, Fe–Si swap, and Fe Mn antisite defects are unlikely to occur. However, the rest of the defects (Fe Si , Mn Si , and Si Fe ) antisites, Mn–Si swap, and Fe vacancy defects have relatively low formation energies that suggest higher probabilities to occur. The band gaps of the defected structures are found to be smaller than the ideal structure with almost zero values in the cases of Fe Si antisite and Fe–Si swap defects. The structure with Fe vacancy defect, however, exhibits almost the same energy gap as that of the ideal structure. The magnetic structure was also affected by the presence of defects except for Fe–Mn and Mn–Si swap defects that show the same total magnetic moment of 3 µ B /f.u. as the ideal structure.
FALSE ATTITUDES IN MEDIEVAL LITERARY CRITICISM (1966)

Journal Article FALSE ATTITUDES IN MEDIEVAL LITERARY CRITICISM Get access Medieval Secular Literature: Four Essays. Ed. William Matthews. Berkeley and Los Angeles: University of California Press, 1965. ix + 89 pp. 30s. D. D. R. OWEN D. D. R. OWEN St Andrews Search for other works by this author on: Oxford Academic Google Scholar Forum for Modern Language Studies, Volume II, Issue 3, July 1966, Pages 281–286, https://doi.org/10.1093/fmls/II.3.281 Published: 01 July 1966