gebhart/patrepeval huggingface dataset:
<i>o</i>-Quinodimethanes:  Efficient Intermediates in Organic Synthesis (1999)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTo-Quinodimethanes: Efficient Intermediates in Organic SynthesisJosé L. Segura and Nazario MartínView Author Information Departamento de Química Orgánica, Facultad de Química, Universidad Complutense, E-28040 Madrid, Spain Cite this: Chem. Rev. 1999, 99, 11, 3199–3246Publication Date (Web):October 16, 1999Publication History Received11 February 1999Revised16 April 1999Published online16 October 1999Published inissue 10 November 1999https://pubs.acs.org/doi/10.1021/cr990011ehttps://doi.org/10.1021/cr990011eresearch-articleACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views7523Altmetric-Citations394LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbon nanomaterials,Monomers,Nanospheres,Polymers,Reaction products Get e-Alerts
AsAP: A Fine-Grained Many-Core Platform for DSP Applications (2007)

Many emerging and future applications require significant levels of complex digital signal processing and operate within limited power budgets. Moreover, dramatically rising VLSI fabrication and design costs make programmable and reconfigurable solutions increasingly attractive. the ASAP project addresses these challenges with a chip multiprocessor composed of simple processors with small memories, achieving high energy efficiency and throughput in a small chip area.
Joseph H. Choate (1918)

Journal Article Joseph H. Choate. New Englander, New Yorker, lawyer, ambassador. By Theron G. Strong. (New York: Dodd, Mead and company, 1917. 390 p. $3.00) Get access F. L. P. F. L. P. Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 4, Issue 4, March 1918, Page 511, https://doi.org/10.2307/1896054 Published: 01 March 1918
The cutaneous uptake of atmospheric oxygen contributes significantly to the oxygen supply of human dermis and epidermis (2002)

It has been known since 1851 that atmospheric oxygen is taken up by the human epidermis. The contribution to total respiration is negligible. Until now the significance for the local oxygen supply of the skin has remained unknown. With a newly developed sensor, the oxygen fluxoptode, it has become possible to make local measurements of the transcutaneous oxygen flux (tcJ(O2)). In this study the sensor was calibrated so that absolute values of tcJ(O2) could be reported. At rest, tcJ(O2) was determined on normal, humidified skin on the volar forearm of 20 volunteers of different age groups. In order to evaluate the contribution of the blood flow to the oxygen supply of the skin, tcJ(O2) was recorded at the end of a 5 min suprasystolic occlusion of the forearm. At normal skin surface partial oxygen pressure (163 +/- 9 Torr), tcJ(O2) was 0.53 +/- 0.27 ml O2 min(-1) x m(-2). A 5 min interruption of blood flow resulted in an increase of 9.5 +/- 6.3 % in tcJ(O2). The value of tcJ(O2) was unaffected by the age of the subject. Published data on the oxygen diffusion properties of skin and simulations of intracutaneous profiles of oxygen partial pressure indicated that under these conditions, the upper skin layers to a depth of of 0.25-0.40 mm are almost exclusively supplied by external oxygen, whereas the oxygen transport of the blood has a minor influence. As a consequence, a malfunction in capillary oxygen transport cannot be the initiator of the development of superficial skin defects such as those observed in chronic venous incompetence and peripheral arterial occlusive disease.
Rare-earth mineral deposits of the Mountain Pass District, San Bernardino County, California, with a foreword on history of the discovery at Mountain Pass, California (1954)

Pyroxene and amphibole.____________ 11 Feldspars _ _______________________ 11 Other minerals____________________ 12 Syenite..._____________________________ 12 Augite-and biotite-rich syenite.______ 13 Coarse-grained syenite_____________ 13 Fine-grained syenite_______________ 13 Quartz syenite____________________ 14 Granite __ ____________________________ 14 Shonkinitic dike rocks___-_-___-___-_-___ 15 Biotite-rich dikes north of Sulphide Queen mine_______________________________ 17 Contacts_________________________________ 18 Alteration__ _ _____________________________ 18 Principal stocks and intrusive bodies_______ 19 Shonkinite-syenite body near Sulphide Queen mine______________________________ 19 Shonkinite-syenite bodies northeast of Grover Spring_________________________ 22 Shonkinite-syenite body southeast of highway maintenance station_________________ 23 Potash-rich syenites near
Structure of a keto derivative of 9,11-dihydrogracilin A (1993)

The X-ray analysis was carried out on the 8-keto derivative of 9,11-dihydrogracilin A, 1,3,3a,4,5,6,7,7a-octahydro-4-oxo-5-(1,3,3-trimethylcyclohexyl)1,3-isobenzofurandiol diacetate, the major metabolite from the Antarctic sponge Dendrilla membranosa. The present study confirms the norditerpenoid skeleton of the spongian type proposed for the natural product by Molinski & Faulkner [J. Org. Chem. (1987), 52, 296-298] on the basis of spectral data and chemical correlations, and also fixes the unknown relative stereochemistry at C10. This result gives further support to the hypothesis regarding the biogenetic origin of the gracilins. The six-membered rings are both in chair conformations and the furan ring is in an envelope form
Experimental Intracerebral Hemorrhage in Rats (1996)

MR images correlate very well with histological changes in this experimental model of intracerebral hemorrhage and can therefore be used to follow changes due to drug treatments in vivo. The intense neutrophilic response to this lesion may contribute to neuronal injury at the periphery of the hematoma.
A 5-Year Surveillance Study of 44,691 Isolates of <i>Haemophilus influenzae</i> Project Beta-Alert 1993–1997 (1999)

Beta-Alert is a surveillance program developed in 1993 to monitor the percentage of beta-lactamase-producing Haemophilus influenzae isolates obtained from specimens submitted to regional commercial laboratories. The results of this study demonstrate that levels of beta-lactamase producers have remained between 31 and 38% in the United States over the past 5 years.
Gastroretentive drug delivery technologies: Current approaches and future potential (2010)

The success of controlled oral drug deliveries is associated with some physiological adversities like short gastric residence time and unpredictable gastric emptying time. Prolonged gastric residence increases duration of drug release, reduces drug waste, and improves drug solubility in gastric pH. This has triggered attention towards development of gastroretentive drug delivery technologies to deliver enarrow absorption windowi drugs with improved bioavailability. The present review addresses briefly about the current status of various leading gastroretentive drug delivery technologies, developed until now, i.e. high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, super porous hydrogel, magnetic systems etc. In addition, important factors controlling gastroretention, advantages and finally, future potential are discussed.
Myosin Binding Protein C Interaction with Actin (2010)

Myosin binding protein C (MyBPC) is a multidomain protein associated with the thick filaments of striated muscle. Although both structural and regulatory roles have been proposed for MyBPC, its interactions with other sarcomeric proteins remain obscure. The current study was designed to examine the actin-binding properties of MyBPC and to define MyBPC domain regions involved in actin interaction. Here, we have expressed full-length mouse cardiac MyBPC (cMyBPC) in a baculovirus system and shown that purified cMyBPC binds actin filaments with an affinity of 4.3 ± 1.1 μM and a 1:1 molar ratio with regard to an actin protomer. The actin binding by cMyBPC is independent of protein phosphorylation status and is not significantly affected by the presence of tropomyosin and troponin on the actin filament. In addition, cMyBPC-actin interaction is not modulated by calmodulin. To determine the region of cMyBPC that is responsible for its interaction with actin, we have expressed and characterized five recombinant proteins encoding fragments of the cMyBPC sequence. Recombinant N-terminal fragments such as C0-C1, C0-C4, and C0-C5 cosediment with actin in a linear, nonsaturable manner. At the same time, MyBPC fragments lacking either the C0-C1 or C0-C4 region bind F-actin with essentially the same properties as full-length protein. Together, our results indicate that cMyBPC interacts with actin via a single, moderate affinity site localized to the C-terminal region of the protein. In contrast, certain basic regions of the N-terminal domains of MyBPC may act as small polycations and therefore bind actin via nonspecific electrostatic interactions.
Precast Partnering Provides Solution for USAA Office Building and Parking Structure (1995)

Precast and prestressed concrete played a prominent role in meeting the stiff requirements of the new USAA Southeast Regional Office Building and Parking Structure in Tampa, Florida. The seven-story office building and five-level parking structure are separated into two curving volumes facing an existing man-made lake. These volumes unite to form a single south facade characterized by a large-scale grid of punched windows in a horizontally banded exterior wall. The free standing 1600-car parking structure is all-precast, employing a distinctive loadbearing ladder wall system with a pretopped double tee floor system. The authors present the architectural requirements and environmental issues, the structural design considerations and some production/erection highlights of the proiect. A key ingredient, which ensured the success of the project, was the concept of partnering ― the theme of which is carried throughout the article
Induction of cPLA2 in Lung Epithelial Cells and Non-small Cell Lung Cancer Is Mediated by Sp1 and c-Jun (2001)

Activating mutations in ras genes are frequently associated with non-small cell lung cancer cells (NSCLC) and contribute to transformed growth in these cells. Expression of oncogenic forms of Ras in these cells is associated with increased expression and activity of cytosolic phospholipase A(2) (cPLA(2)) and cyclooxygenase-2 (COX-2), leading to constitutively elevated levels of prostaglandin production. Expression of oncogenic Ras is sufficient to induce these enzymes in normal lung epithelial cells. We have previously reported that the JNK and ERK pathways are necessary for induction of cPLA(2) and have defined a minimal region of the cPLA(2) promoter from -58 to -12 that is required for Ha-Ras-mediated induction. To further characterize the cis-regulatory elements within this region involved in this response, site-directed mutagenesis was used to make mutations at various sites. Three cis-regulatory elements were identified: regions -21/-18, -37/-30, and -55/-53. Mutations in any of these elements decreased basal and Ha-Ras-induced cPLA(2) promoter activity in both normal lung epithelial cells, as well as steady state promoter activity in A549 cells, with a mutation in element -21/-18 completely eliminating all promoter activity. Overexpression studies and gel shift assays indicated that Sp1 may serve as a transcription factor functionally regulating promoter activity by directly interacting with two of the cis-regulatory elements, -21/-18 and -37/-30. Expression of Ha-Ras led to induction of c-Jun protein, which showed functional cooperation with Sp1 in driving promoter activity. Additional unidentified transcription factors bound to the regions from -55/-53 and -37/-34.
ICU Admission, Discharge, and Triage Guidelines: A Framework to Enhance Clinical Operations, Development of Institutional Policies, and Further Research (2016)

Although these are administrative guidelines, the subjects addressed encompass complex ethical and medico-legal aspects of patient care that affect daily clinical practice. A limited amount of high-quality evidence made it difficult to answer all the questions asked related to ICU admission, discharge, and triage. Despite these limitations, the members of the Task Force believe that these recommendations provide a comprehensive framework to guide practitioners in making informed decisions during the admission, discharge, and triage process as well as in resolving issues of nonbeneficial treatment and rationing. We need to further develop preventive strategies to reduce the burden of critical illness, educate our noncritical care colleagues about these interventions, and improve our outreach, developing early identification and intervention systems.
Nonlinkage of Neurovirulence Exclusively to Viral Hemagglutinin or Neuraminidase in Genetic Recombinants of A/NWS (H0N1) Influenza Virus (1973)

Genetic recombination of the neurovirulent A/NWS/cc-p (H0N1) and the non-neurovirulent A/Jap.305/57 (H2N2) influenza viruses in which hemagglutinin and neuraminidase were segregated (H0N2, H2N1) were studied for neurovirulence in mice immunosuppressed with cyclophosphamide (CPA) which permitted full expression of virulence. Both H0N2 and H2N1 recombinants replicated in the brain (in contrast to the H2N2 parent) and both produced lethal effects in CPA-treated animals. Therefore we conclude that A/NWS (H0N1) neurovirulence is not exclusively linked with either the hemagglutinin or the neuraminidase of the virus. The H0N2 and H2N1 recombinants have revealed the existence of two separate attributes of neurovirulence: (i) the capacity of virus to initiate intracerebral infection and (ii) the capacity of infection, once initiated, to produce lethal disease. These studies provide further evidence for the polygenic nature of A/NWS neurovirulence.
Therapy with granulocyte colony-stimulating factor in systemic lupus erythematosus may be associated with severe flares. (2006)

Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used for treatment of febrile neutropenia in systemic lupus erythematosus (SLE) and other systemic rheumatic diseases. We describe 2 patients with SLE with disease flares with irreversible loss of renal function in association with G-CSF therapy. Eighteen patients with SLE treated with G-CSF for neutropenia have been reported, of whom 4 developed mild disease flares or cutaneous vasculitis. Our experience suggests that G-CSF therapy should be used with considerable caution in patients with SLE.
Reciprocal Protein Kinase A Regulatory Interactions between Cystic Fibrosis Transmembrane Conductance Regulator and Na+/H+ Exchanger Isoform 3 in a Renal Polarized Epithelial Cell Model (2002)

Although Cystic fibrosis transmembrane conductance regulator (CFTR) has been shown to regulate the activity of NHE3, the potential reciprocal interaction of NHE3 to modulate the protein kinase A (PKA)-dependent regulation of CFTR in epithelial cells is still unknown. In the present work, we describe experiments to define the interactions between CFTR and NHE3 with the regulatory, scaffolding protein, NHERF that organize their PKA-dependent regulation in a renal epithelial cell line that expresses endogenous CFTR. The expression of rat NHE3 significantly decreased PKA-dependent activation of CFTR without altering CFTR expression, and this decrease was prevented by mutation of either of the two rat NHE3 PKA target serines to alanine (S552A or S605A). Inhibition of CFTR expression by antisense treatment resulted in an acute decrease in PKA-dependent regulation of NHE3 activity. CFTR, NHE3, and ezrin were recognized by NHERF-2 but not NHERF-1 in glutathione S-transferase pull-down experiments. Ezrin may function as a protein kinase A anchoring protein (AKAP) in this signaling complex, because blocking the binding of PKA to an AKAP by incubation with the S-Ht31 peptide inhibited the PKA-dependent regulation of CFTR in the absence of NHE3. In the A6-NHE3 cells S-Ht31 blocked the PKA regulation of NHE3 whereas it now failed to affect the regulation of CFTR. We conclude that CFTR and NHE3 reciprocally interact via a shared regulatory complex comprised of NHERF-2, ezrin, and PKA.
Methoden zur Beschreibung der Wolkenentwicklung in Satellitenbildern und ihre Anwendung zur Solarstrahlungsvorhersage (2005)

Ziel dieser Arbeit war die Entwicklung eines Verfahrens zur Vorhersage der Solarstrahlung im Kurzzeitbereich (bis zu 6h) für Solarenergieanwendungen. Die Vorhersage der Strahlung beruht auf einer Vorhersage der Bewölkungsentwicklung in Satellitenbildern. Aus den vorhergesagten Bewölkungsituationen wird mit der Heliosat-Methode, einem statistischen Verfahren zur Berechnung der Globalstrahlung aus Satellitendaten, eine Vorhersage der Solarstrahlung am Boden abgeleitet. Zur Beschreibung der Wolkenentwicklung in Satellitenbildern wurden zwei verschiedene Ansätze untersucht: Neuronale Netze und Vorhersagen mit Bewegungsvektorfeldern. Es wurde gezeigt, dass mit Bewegungsvektorfeldern eine deutlich bessere Vorhersage der Wolkenentwicklung erzielt wird. Eine detaillierte Genauigkeitsanalyse der Strahlungsvorhersage auf der Basis von Bewegungsvektorfeldern wurde durchgeführt, wobei besonderes Gewicht auf der Unterscheidung von Situationen unterschiedlicher Vorhersagequalität lag.
Olfactory studies on enantiomeric eremophilane sesquiterpenoids (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOlfactory studies on enantiomeric eremophilane sesquiterpenoidsHerman G. Haring, Ferdinand Rijkens, Harmannus Boelens, and Arne Van der GenCite this: J. Agric. Food Chem. 1972, 20, 5, 1018–1021Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/jf60183a011https://doi.org/10.1021/jf60183a011research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improving a supplier's quantity discount gain from many different buyers (2000)

Abstract We consider the pricing and inventory decisions of a vendor who supplies a single product to multiple heterogeneous buyers. The problem is analyzed as a Stackelberg game in which the vendor acts as the leader by announcing its pricing policy to all the buyers in advance and the buyers act as followers by choosing their order quantity and the sassociated purchasing price independently under the vendors' pricing scheme. We propose in this paper a pricing policy for the vendor that offers price discounts based on the percentage increase from a buyers' order quantity before discount. The proposed policy is defined as a discrete all-unit quantity discount schedule with many break points. We show that: (i) the proposed policy offers a higher price discount to a buyer ordering a larger quantity and hence complies with general fair trade laws; (ii) an explicit solution is obtained for the vendors' optimal decision; and (iii) although suppliers in reality normally offer price discounts based on a buyers' unit increase in order quantity, the proposed policy is superior for the vendor when there are many different buyers. Other benefits of the proposed pricing policy are demonstrated by numerical examples.
Fat content affects heat capacity: a study in mice (1995)

The specific heat capacity of the human body is a widely used number in calculations related to studies in energy metabolism and temperature regulation. A value of 3.47 kJ kg-1 K-1 has been used during the last century, but there have been no direct studies on the dependence of this value on the body fat content. We present here results of measurements of the specific heat capacity of lean and obese mice. The mice were killed and heated to 40.6 degrees C, transferred to a calorimeter and the specific heat capacity was determined from body mass of the mice and temperature rise of water in the calorimeter. We measured the fat fraction of body mass (mf), fat free body mass and water content of the mice and found a marked dependency of the specific heat capacity (Cp) on body fat. In obese mice (fat content 52.76% body wt) the heat capacity was 2.65 kJ kg-1 K-1 and in lean mice (fat content 7.55% body wt) the heat capacity was 3.66 kJ kg-1 K-1.