gebhart/patrepeval huggingface dataset:
The Inhibition by Phlorizin of Kidney Microsomal Inorganic Pyrophosphate-Glucose Phosphotransferase and Glucose 6-Phosphatase (1967)

Abstract Glucose 6-phosphatase from rat liver and kidney microsomes previously has been shown to catalyze an inorganic pyrophosphate-glucose phosphotransferase reaction. Nordlie and Soodsma recently have suggested that formation and then degradation of glucose 6-phosphate by the combined action of phosphotransferase and phosphohydrolase activities of this enzyme may under certain conditions constitute part of a mechanism for facilitated transport of glucose across the kidney tubular cell. To attempt to gain additional insight regarding the possible significance of such a physiological role for the enzyme, studies of the effect of phlorizin, a potent inhibitor of tubular sugar transport, on both phosphohydrolase and phosphotransferase activities of this enzyme were undertaken. Inhibition, in vitro, of both glucose 6-phosphate phosphohydrolase and pyrophosphate-glucose phosphotransferase activities of kidney homogenates and microsomal suspensions prepared in isotonic sucrose solution was noted over the entire range of phlorizin concentrations studied, 6.7 x 10-5 m to 6.7 mm. Sensitivity of activities to inhibition by this compound was either partially or completely abolished by supplementation of the homogenates or microsomal suspensions, to 0.2% (w/v), with sodium deoxycholate, sodium cholate, digitonin, Triton X-100, or Tween 20. Phlorizin was without discernible effect on activity of partially purified enzyme preparations obtained by fractional ammonium sulfate precipitation of deoxycholate-dispersed microsomal suspensions. Inhibition of phosphotransferase activity in homogenates or microsomes was markedly potentiated by the cationic detergent trimethylhexadecylammonium bromide. Kinetic analyses indicated that inhibition of both phosphohydrolase and phosphotransferase activities by phlorizin was of the classical noncompetitive type. A value of approximately 0.7 mm for Ki for phlorizin was determined in the absence of detergent; the value was reduced to 0.2 InM when trimethylhexadecylammonium bromide was added (to 0.2%, w/v) to enzyme preparations prior to assay for activity. The effects of the administration in vivo of phlorizin on phosphotransferase activity of the enzyme were also studied. Reductions in activity per mg of kidney protein of as much as 18% were produced by intravenous injection of 0.1-g doses of phlorizin to rats. The data obtained appear to rationalize the initially apparently contradictory reports of earlier workers regarding the effects (or lack of effect) of phlorizin on glucose 6-phosphatase. The experimental observations reported in this paper also are interpreted to constitute added support for, but not direct proof of, the possible involvement of synthetic and hydrolytic activities of this enzyme in kidney glucose transport. It is suggested that the modifying effects of various detergents on phlorizin-sensitivity of the enzyme are manifest through selective action on both active and inactive silent phlorizin-binding sites in the enzyme preparation.
Epoxide Opening versus Silica Condensation during Sol–Gel Hybrid Biomaterial Synthesis (2013)

Hybrid organic-inorganic solids represent an important class of engineering materials, usually prepared by sol-gel processes by cross-reaction between organic and inorganic precursors. The choice of the two components and control of the reaction conditions (especially pH value) allow the synthesis of hybrid materials with novel properties and functionalities. 3-Glycidoxypropyltrimethoxysilane (GPTMS) is one of the most commonly used organic silanes for hybrid-material fabrication. Herein, the reactivity of GPTMS in water at different pH values (pH 2-11) was deeply investigated for the first time by solution-state multinuclear NMR spectroscopic and mass spectrometric analysis. The extent of the different and competing reactions that take place as a function of the pH value was elucidated. The NMR spectroscopic and mass spectrometric data clearly indicate that the pH value determines the kinetics of epoxide hydrolysis versus silicon condensation. Under slighly acidic conditions, the epoxy-ring hydrolysis is kinetically more favourable than the formation of the silica network. In contrast, under basic conditions, silicon condensation is the main reaction that takes place. Full characterisation of the formed intermediates was carried out by using NMR spectroscopic and mass spectrometric analysis. These results indicate that strict control of the pH values allows tuning of the reactivity of the organic and inorganic moities, thus laying the foundations for the design and synthesis of sol-gel hybrid biomaterials with tuneable properties.
Epidemiology and Risk Factors for Isolation of Escherichia coli Producing CTX-M-Type Extended-Spectrum β-Lactamase in a Large U.S. Medical Center (2013)

A case-case-control study was conducted to identify independent risk factors for recovery of Escherichia coli strains producing CTX-M-type extended-spectrum β-lactamases (CTX-M E. coli) within a large Southeastern Michigan medical center. Unique cases with isolation of ESBL-producing E. coli from February 2010 through July 2011 were analyzed by PCR for blaCTX-M, blaTEM, and blaSHV genes. Patients with CTX-M E. coli were compared to patients with E. coli strains not producing CTX-M-type ESBLs (non-CTX-M E. coli) and uninfected controls. Of 575 patients with ESBL-producing E. coli, 491 (85.4%) isolates contained a CTX-M ESBL gene. A total of 319 (84.6%) patients with CTX-M E. coli (282 [74.8%] CTX-M-15 type) were compared to 58 (15.4%) non-CTX-M E. coli patients and to uninfected controls. Independent risk factors for CTX-M E. coli isolation compared to non-CTX-M E. coli included male gender, impaired consciousness, H2 blocker use, immunosuppression, and exposure to penicillins and/or trimethoprim-sulfamethoxazole. Compared to uninfected controls, independent risk factors for isolation of CTX-M E. coli included presence of a urinary catheter, previous urinary tract infection, exposure to oxyimino-cephalosporins, dependent functional status, non-home residence, and multiple comorbid conditions. Within 48 h of admission, community-acquired CTX-M E. coli (n = 51 [16%]) and non-CTX-M E coli (n = 11 [19%]) strains were isolated from patients with no recent health care contacts. CTX-M E. coli strains were more resistant to multiple antibiotics than non-CTX-M E. coli strains. CTX-M-encoding genes, especially bla(CTX-M-15) type, represented the most common ESBL determinants from ESBL-producing E. coli, the majority of which were present upon admission. Septic patients with risk factors for isolation of CTX-M E. coli should be empirically treated with appropriate agents. Regional infection control efforts and judicious antibiotic use are needed to control the spread of these organisms.
Stereoselective and hierarchical self-assembly from nanotubular homochiral helical coordination polymers to supramolecular gels (2010)

A new binaphthylbisbipyridine-based ligand underwent diastereoselective self-assembly with silver(I) ions to form nanotubular homochiral helical coordination polymers, which further hierarchically self-assemble into nanofibers, capable of immobilizing organic solvents.
THE NATURE OF THE ANTIGEN-ANTIBODY COMPLEXES WHICH INITIATE ANAPHYLACTIC REACTIONS. II. THE EFFECT OF MOLECULAR SIZE ON THE ABILITIES OF HOMOLOGOUS MULTIVALENT BENZYLPENICILLOYL HAPTENS TO EVOKE PCA AND PASSIVE ARTHUS REACTIONS IN THE GUINEA PIG. (1965)

Summary A divalent benzylpenicilloyl (BPO) hapten and several homologous multivalent BPO haptens of widely differing molecular sizes were compared quantitatively with regard to their abilities to evoke PCA reactions in guinea pigs passively sensitized with threshold, optimal and excess amounts of rabbit anti-BPO antibodies. These haptens were compared also with regard to their abilities to specifically precipitate rabbit anti-BPO sera, and to evoke passive Arthus reactions. It was found that equimolar concentrations (and not equal weight concentrations) of the divalent and of the multivalent haptens were equally effective in evoking PCA reactions throughout the dose-response curve. In contrast, equal weight concentrations of the multivalent haptens (and not equimolar concentrations) were found to be equally effective in precipitating anti-BPO sera, and in evoking passive direct Arthus reactions in guinea pigs sensitized with rabbit anti-BPO sera. The divalent hapten was virtually ineffective in precipitating anti-BPO antibodies present in these sera, and failed to evoke passive direct Arthus reactions. These results are interpreted as demonstrating, at least in this system, that, whereas the precipitin reaction and the passive direct Arthus reaction depend on the formation of large cross-linked complexes, the PCA reaction in guinea pigs is initiated by the simple bridging of two (or a small integer (n)) firmly fixed anaphylactic antibody molecules by multivalent haptens to form comparatively simple immune complexes of the composition H 1 Ab n .
Infection in Organ-Transplant Recipients (1998)

A primary goal in organ transplantation is the prevention or effective treatment of infection, the most common life-threatening complication of long-term immunosuppressive therapy. The challenges involved in achieving this goal are several: a broad range of potential sources of infection ranging from latent viruses to pathogens of both community and hospital origin; immunosuppression-induced impairment of the inflammatory response, which attenuates the signs and symptoms of invasive infection; and the adverse effects of the antimicrobial drugs used for prophylaxis and therapy, which result both from the duration of therapy required and from interactions with the immunosuppressive drugs cyclosporine and tacrolimus. Our . . .
Pattern Matching in Trees (1982)

ABSTgACT. Tree pattern matching is an interesting special problem which occurs as a crucial step m a number of programmmg tasks, for instance, design of interpreters for nonprocedural programming languages, automatic implementations of abstract data types, code optimization m compilers, symbohc computation, context searching in structure editors, and automatic theorem provmg. As with the sorting problem, the variations in requirements and resources for each application seem to preclude a uniform, umversal solution to the tree-pattern-matching problem. Instead, a collection of well-analyzed techmques, from which specific applications may be selected and adapted, should be sought. Five new techniques for tree pattern matching are presented, analyzed for time and space complexity, and compared with previously known methods. Particularly important are applications where the same patterns are matched against many subjects and where a subject may be modified incrementally Therefore, methods which spend some tune preprocessmg patterns in order to improve the actual matching time are included Categories and SubJect Descriptors' F.2.
Occupancy-map-based rate distortion optimization for video-based point cloud compression (2019)

The state-of-the-art video-based point cloud compression scheme projects the 3D point cloud to 2D patch by patch and organizes the patches into frames to compress them using the efficient video compression scheme. Such a scheme shows a good trade-off between the number of points projected and the video continuity to utilize the video compression scheme. However, some unoccupied pixels between different patches are compressed using almost the same quality with the occupied pixels, which will lead to the waste of lots of bits since the unoccupied pixels are useless for the reconstructed point cloud. In this paper, we propose to consider only the rate instead of the rate distortion cost for the unoccupied pixels during the rate distortion optimization process. The proposed scheme can be applied to both the geometry and attribute frames. The experimental results show that the proposed algorithm can achieve an average of 11.9% and 15.4% bitrate savings for the geometry and attribute, respectively.
Lipid‐Anchored Oligonucleotides for Stable Double‐Helix Formation in Distinct Membrane Domains (2006)

Anchoring for DNA: A lipophilic oligonucleotide consisting of 21 thymidine units and two lipophilic nucleotides L was synthesized and bound to vesicular surfaces (see fluorescence image). The membrane-bound oligonucleotide binds complementary DNA strands by formation of Watson–Crick base pairs. The lipid-anchored oligonucleotide is preferentially enriched in liquid-disordered membrane domains.
Cultural Identity and Cultural Interaction: Greek Music in the United States, 1917–1941 (1995)

The rebétiko music played by Greek immigrants in the United States and recorded by American companies reflects the traditional culture of the immigrants and may thus serve to illuminate the attitude of the immigrant artist toward his or her ethnic identity and the problems of becoming integrated into new cultural surroundings. Before we can judge the actual music and its cultural significance, we must have precise ideas about which materials may be used to determine the musical culture in the immigrant community. Were recordings in Athens made with the Greek-American public in mind? As a rule, Greek musicians stayed outside the mainstream of American popular music; only in rare cases did they change their traditional means of expression. There are few examples of influence from other popular ethnic music cultures in the United States. One of the main differences between the Greek and the Greek-American rebétika songs seems to be the attitude to drugs; there are so few drug songs in the recorded American output of rebétika that this must reflect a deliberate choice either by the musicians or by the record companies.
Hydrogel polymer coating for capillary electrophoretic separation of proteins (1992)

Abstract Three hydrogel polymers, poly(2‐hydroxypropylmethacrylate), poly(2‐hydroxyethylmethacrylate), and hydroxypropylcellulose, were coated and immobilized on fused silica capillary surfaces using three different methods, all involving modification of the surfaces before polymeriszation and/or cross‐linking. Since the hydrogel polymers swelled in aqueous solution and allowed permeation of low‐molecular‐weight compounds, an equilibrated state was attained between the hydrogel polymer layers and the buffer solution, which eliminated the interactions between proteins and the capillary surface, and allowed highly efficient and reproducible capillary electrophoretic separations of both basic and acidic proteins. The experimental results indicated that silanol groups on the capillary surface were covered and phosphate anions were trapped in the coating layers, which produced defined, but reduced, electroosmotic flows when compared to uncoated capillaries. High resolution separations of ribonuclease B variants and cytochrome c proteins from different sources were obtained.
The Influence of 1960's Futurism on Modern Make-up (2008)

초록·키워드 목차 오류제보하기 등록된 정보가 없습니다. #fashion #futurism #make-up 등록된 정보가 없습니다.
Recommender system based on the analysis of publicly available data (2017)

A recommender system is a software system aimed to make recommendations. To be able to do that, recommender system feature several components, such as: data collection and processing, recommender model, recommendation post-processing and a user interface. Recommender systems apply one or the combination of few of the recommendation techniques. In this paper we present recommender system developed to provide users with recommendations in accordance with their interests in different domains. We deduce user interests based on his activities and posts in social network. Social network used as a source of information on user (Facebook) provides Open API allowing access to the information about the user collected on the social network. Thanks to this data we are overcoming the so-called “cold start” problem and building user profile. A recommender system is commonly associated with only one domain, while the recommender system described in this paper is able to generate recommendations from different domains (movies and music). In addition to recommendations related with the specific domain, our system is able to recommend the web articles (unstructured text), relevant to the user that may belong to more than one category of interest.
The amylase and maltase of <i>Clostridium acetobutylicum</i> (1945)

Research Article| January 01 1945 The amylase and maltase of Clostridium acetobutylicum D. J. D. Hockenhull; D. J. D. Hockenhull 1Medical Research Council Unit for Chemical Microbiology, the Biochemical Laboratory, Cambridge Search for other works by this author on: This Site PubMed Google Scholar D. Herbert D. Herbert 1Medical Research Council Unit for Chemical Microbiology, the Biochemical Laboratory, Cambridge Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1945) 39 (1): 102–106. https://doi.org/10.1042/bj0390102 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation D. J. D. Hockenhull, D. Herbert; The amylase and maltase of Clostridium acetobutylicum. Biochem J 1 January 1945; 39 (1): 102–106. doi: https://doi.org/10.1042/bj0390102 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search © 1945 CAMBRIDGE UNIVERSITY PRESS, ENGLAND1945 Article PDF first page preview Close Modal You do not currently have access to this content.
Arabidopsis Cys2/His2-Type Zinc-Finger Proteins Function as Transcription Repressors under Drought, Cold, and High-Salinity Stress Conditions (2004)

ZPT2-related proteins that have two canonical Cys-2/His-2-type zinc-finger motifs in their molecules are members of a family of plant transcription factors. To characterize the role of this type of protein, we analyzed the function of Arabidopsis L. Heynh. genes encoding four different ZPT2-related proteins (AZF1, AZF2, AZF3, and STZ). Gel-shift analysis showed that the AZFs and STZ bind to A(G/C)T repeats within an EP2 sequence, known as a target sequence of some petunia (Petunia hybrida) ZPT2 proteins. Transient expression analysis using synthetic green fluorescent protein fusion genes indicated that the AZFs and STZ are preferentially localized to the nucleus. These four ZPT2-related proteins were shown to act as transcriptional repressors that down-regulate the transactivation activity of other transcription factors. RNA gel-blot analysis showed that expression of AZF2 and STZ was strongly induced by dehydration, high-salt and cold stresses, and abscisic acid treatment. Histochemical analysis of beta-glucuronidase activities driven by the AZF2 or STZ promoters revealed that both genes are induced in leaves rather than roots of rosette plants by the stresses. Transgenic Arabidopsis overexpressing STZ showed growth retardation and tolerance to drought stress. These results suggest that AZF2 and STZ function as transcriptional repressors to increase stress tolerance following growth retardation.
Solubilization of steroid hormones by polyoxyethylene lauryl ether. (1978)

As a further approach to an understanding of a relationship between the magnitudes of micellar solubilization and the hydrophobicities of solubilizates, steroid hormones (19 species) were selected to explore the meaning of the intercept b value. Two linear free energy relationships were established between the aqueous-polyoxyethylene lauryl ether micellar partition coefficient (K) and the partition coefficient (Poctanol) between aqueous solution and n-octanol. One consisted of the steroids carrying a fluorine atom at a carbon 9 and the other of those carrying no fluorine atom. The b value predicted that the fluorine steroids are solubilized in the outer layer of the mantle while the others are incorporated into rather inner position, which was consistent with the experimental results.
True language-level SQL debugging (2011)

We demonstrate Habitat, a declarative observational debugger for SQL. Habitat facilitates true language-level (not: plan-level) debugging of, probably flawed, SQL queries that yield unexpected results. Users may mark arbitrary SQL subexpressions---ranging from literals, over fragments of predicates, to entire subquery blocks---to observe whether these evaluate as expected.
Online detection of network traffic anomalies using behavioral distance (2009)

While network-wide anomaly analysis has been well studied, the on-line detection of network traffic anomalies at a vantage point inside the Internet still poses quite a challenge to network administrators. In this paper, we develop a behavioral distance based anomaly detection mechanism with the capability of performing on-line traffic analysis. To construct accurate online traffic profiles, we introduce horizontal and vertical distance metrics between various traffic features (i.e., packet header fields) in the traffic data streams. The significant advantages of the proposed approach lie in four aspects: (1) it is efficient and simple enough to process on-line traffic data; (2) it facilitates protocol behavioral analysis without maintaining per-flow state; (3) it is scalable to high speed traffic links because of the aggregation, and (4) using various combinations of packet features and measuring distances between them, it is capable for accurate on-line anomaly detection. We validate the efficacy of our proposed detection system by using network traffic traces collected at Abilene and MAWI high-speed links.
Proton‐conducting polyhedral oligosilsesquioxane nanoadditives for sulfonated polyphenylsulfone hydrogen fuel cell proton exchange membranes (2008)

Abstract Three novel polyhedral oligosilsesquioxane (POSS) nanofillers functionalized with proton‐conducting sulfonic acid groups, mixed sulfonic acid and alkyl groups, and phosphonic acid groups were synthesized, characterized by IR, 1 H and 13 C NMR, and MALDI‐TOF MS, and formulated into sulfonated polyphenylsulfone (S‐PPSU) carrier polymers. High quality films were cast from 1‐methyl‐2‐pyrrolidinone (NMP), and through‐plane and in‐plane proton conductivity, mechanical properties, water uptake, dimensional stability, and leaching behavior were measured to assess their suitability for use as hydrogen fuel cell proton exchange membranes. Various nanofiller loadings and S‐PPSU sulfonation levels were studied. The morphologies of the composite membranes were determined by TEM and SEM X‐ray mapping. When compared with Nafion®, the POSS‐S‐PPSU composite membranes exhibited comparable proton conductivity in combination with superior dimensional stability, heat resistance, and mechanical strength. When compared with control S‐PPSU membranes, the composite POSS‐S‐PPSU membranes exhibited superior conductivity, comparable dimensional stability, and slightly decreased mechanical strength. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008