gebhart/patrepeval huggingface dataset:
SUMOylation Code in Cancer Development and Metastasis (2006)

Protein modification by small ubiquitin-like modifier (SUMO) controls diverse cellular functions of protein targets including transcription factors and coregulators mainly in the nucleus and participates in maintaining cellular homeostasis. In addition, SUMO system plays important roles in DNA damage repair and maintaining genome integrity. Thus, in some cases, the loss of control on SUMOylation or deSUMOylation processes causes a defect in maintaining homeostasis and hence gives a cue to cancer development. Furthermore, recent study showed that SUMO system is also involved in cancer metastasis. In this review, we will summarize and discuss the possible role of SUMO system in cancer development and metastasis.
Antitumor activity of periodate-oxidation products of carbohydrates and their derivatives. (1966)

The inhibitory effects of a number of periodate-oxidation products of carbohydrates and carbohydrate derivatives were studied on various transplanted tumors in mice and on a variety of microorganisms. Many of the compounds showed striking inhibition of Ehrlich ascites and inhibition of Leukemia L1210 in mice. The compounds were not active against Sarcoma 180 and Adenocarcinoma 755 or against any of the microorganisms studied.
Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases (2017)

Until 2004, many researchers believed that protein methylation in eukaryotic cells was an irreversible reaction. However, the discovery of lysine-specific demethylase 1 in 2004 drastically changed this view and the concept of chromatin regulation. Since then, the enzymes responsible for lysine demethylation and their cellular substrates, biological significance, and selective regulation have become major research topics in epigenetics and chromatin biology. Many cell-permeable inhibitors for lysine demethylases have been developed, including both target-specific and nonspecific inhibitors. Structural understanding of how these inhibitors bind to lysine demethylases is crucial both for validation of the inhibitors as chemical probes and for the rational design of more potent, target-specific inhibitors. This review focuses on published small-molecule inhibitors targeted at the two flavin adenine dinucleotide-dependent lysine demethylases, lysine-specific demethylases 1 and 2, and how the inhibitors interact with the tertiary structures of the enzymes.
[New drugs that prevent cytotoxicity of Shiga toxins]. (2002)

Shiga toxin(Stx) produced by enterohemorrhagic E. coli is the virulence factor that causes not only enterohemorrhagic colitis but also fatal complications, such as hemolytic uremic syndrome. To prevent the complications, new strategies targeted to Stx have been tested, mostly using mimics of the trisaccharide structure of neutral lipid Gb3, the receptor for Stx. One group of such new drugs are agents that can bind to Stx in gastrointestinal tract and prevent its spread to extraintestinal sites, and the other group are water-soluble neutralizers that suppress Stx cytotoxicity in the circulation. Although most of these are now under the laboratory investigations, one of these drugs may hopefully be utilized clinically to prevent hemolytic uremic syndrome in future.
Managing External Parasites of Texas Livestock and Poultry. (1997)

B-13064-00 5 Avoid contamination of feed, mangers, water, milk and milking equipment.5 Do not spread treated manure on cropland unless label approval is given.5 Store pesticides in the original, labeled containers, safely locked away from children, pets and livestock.5 Dispose of empty pesticide containers promptly and properly according to specified recommendations.Stay out of the smoke if containers are burned.5 Contact a physician at once in all cases of suspected poisoning.Symptoms of organic phosphate poisoning include blurred vision, abdominal cramps and tightness in the chest.Atropine is antidotal for some organophosphorus pesticides.
Catalyst Formulations 1960 to Present (1989)

<div class="htmlview paragraph">The primary topic of this paper is the evolution of the early oxidation catalysts of the 1960's to present-day sophisticated three-way catalysts. Early catalyst formulations are described, along with the chemistry of catalytic emission control for automobiles. The evolution in catalyst formulations and engine control strategy is discussed at length. Precious metal supply and world emission regulations are discussed briefly. The scope of this paper is primarily limited to the U.S. automotive industry and the U.S. standards.</div>
Building a Multilingual Lexical Resource for Named Entity Disambiguation, Translation and Transliteration (2008)

Comunicació presentada a: the Sixth International Language Resources and Evaluation (LREC'08), celebrada del 26 de maig a l'1 de juny de 2008 a Marràqueix, Marroc.
Induction and expression of seed‐specific promoters in <i>Arabidopsis</i> embryo‐defective mutants (1996)

In order to assess the importance of morphogenesis on the induction of promoter markers for storage and Lea programmes, advantage was taken of the emb mutations producing embryos arrested at a wide range of developmental stages in Arabidopsis. These embryos are viable during their stage of developmental arrest and continue to divide further, but apparently without further differentiation into the main organs and tissues of the normal embryos. Eight independent emb mutants arrested in their development prior to the cotyledon stage were selected. These emb embryos lack the normal morphology of the wild-type embryos when the synthesis of storage and Lea proteins are normally initiated. The 2S1-uidA chimeric gene, representative of the maturation programme and the Em 1-uidA chimeric gene, representative of the desiccation programme were introduced by crosses into the emb background. In the eight emb lines, the expression of the GUS reporter gene directed by the 2S1 and Em 1 promoters was observed in the aborted seeds irrespective of their stage of developmental arrest. The time of induction of the expression of both promoters was the same in the arrested embryos as compared with the normal embryos within the same silique. Thus, the activation of these two promoters is triggered by the same signal and can occur in the absence of morphogenesis. However, in the absence of normal organ formation, the expression of the reporter gene under the control of the 2S1 and Em1 promoters was evident throughout the whole seed tissues. In normal seed development, the hormone abscisic acid (ABA) activates the promoters of the 2S1 and Em 1 genes. One of the important members of the signal transduction pathway of ABA is the ABI3 protein. It has been shown previously that this protein is a prerequisite for the induction of Em 1 by ABA in seeds. A good correlation with the expression of the ABI3 promoter and the 2S1 and Em 1 promoters was found in emb seeds tissues. This observation suggests that the promoters of the 2S1 and the Em 1 genes are expressed in the mutant seeds not at a basal level, but are probably induced by ABA, as in normal seed development.
THE DRY MATTER DIGESTION <i>IN VITRO</i> OF FORAGE CROPS (1960)

An artificial rumen technique was evaluated as a method of determining the dry matter digestion of forages. The digestibility estimates obtained in the spring were significantly correlated (r = 0.77 xx ) with estimates obtained on these forages from a conventional digestion trial, whereas in the fall the coefficients were low and no longer significantly correlated (r = 0.49) with the conventional trial data.A medium maturing timothy polycross nursery was harvested at 10-day intervals throughout the first growth cycle. With the exception of the April 14th stage there were no significant differences in digestibility between the clones harvested in the early-leaf stage. Significant differences between selections were obtained in digestibility at later stages of maturity which may be a function of the leaf-stem ratio, the amount of leaf firing and thickness of the culms as well as changes in chemical composition. The per cent fructose content of this timothy herbage was significantly correlated (r = 0.78 xx ) with the dry matter digestibility only at the first stage of cutting.Changes in dry matter digestion using this artificial rumen technique were observed, with digestion estimates being higher during the spring and summer than during fall and winter.The method of drying herbage for these in vitro digestion experiments was studied with the conclusion that there was a significant difference in favour of freeze-drying. The dry matter digestion coefficients of the freeze-dried herbage were comparable to those expected for herbage of such quality digested in vivo.The use of an artificial rumen technique for estimating digestibility of clonal material shows promise for the plant breeder, providing certain precautions are taken. All lines to be screened should be included in a single trial to ensure maximum control of variables associated with technique. Samples should be uniformly processed, preferably freeze-dried, and digested with a single sample of rumen fluid.
Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles (2011)

Disease development in human T-cell leukemia virus type 1 (HTLV-1)-infected individuals is positively correlated with the level of integrated viral DNA in T cells. HTLV-1 replication is positively regulated by Tax and Rex and negatively regulated by the p30 and HBZ proteins. In the present study, we demonstrate that HTLV-1 encodes another negative regulator of virus expression, the p13 protein. Expressed separately, p13 localizes to the mitochondria, whereas in the presence of Tax, part of it is ubiquitinated, stabilized, and rerouted to the nuclear speckles. The p13 protein directly binds Tax, decreases Tax binding to the CBP/p300 transcriptional coactivator, and, by reducing Tax transcriptional activity, suppresses viral expression. Because Tax stabilizes its own repressor, these findings suggest that HTLV-1 has evolved a complex mechanism to control its own replication. Further, these results highlight the importance of studying the function of the HTLV-1 viral proteins, not only in isolation, but also in the context of full viral replication.
High yield fabrication of fluorescent nanodiamonds (2009)

A new fabrication method to produce homogeneously fluorescent nanodiamonds with high yields is described. The powder obtained by high energy ball milling of fluorescent high pressure, high temperature diamond microcrystals was converted in a pure concentrated aqueous colloidal dispersion of highly crystalline ultrasmall nanoparticles with a mean size less than or equal to 10 nm. The whole fabrication yield of colloidal quasi-spherical nanodiamonds was several orders of magnitude higher than those previously reported starting from microdiamonds. The results open up avenues for the industrial cost-effective production of fluorescent nanodiamonds with well-controlled properties.
A Multi-Standard Analog and Digital TV Tuner for Cable and Terrestrial Applications (2007)

A TV tuner fully compliant with ATSC, NTSC, PAL, SECAM, OVB-T, ISDB-T and DMB-T/H standards is described. An array of power detectors and fine-step-size digital gain controls are used to achieve an optimum signal-path gain. The tuner achieves an input sensitivity of better than -84dBm for ATSC digital off-air signals. Implemented in a 0.35mum SiGe BiCMOS process, it occupies 7.3mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and consumes 1.5W from a split 5V/3.3V supply
Tau Triage Decisions Mediated by the Chaperone Network (2012)

The pathological accumulation of the microtubule-binding protein tau is linked to an increasing number of neurodegenerative conditions associated with aging, though the mechanisms by which tau accumulates in disease are unclear. In this review, we will summarize our previous research assessing the mechanism of action, as well as the therapeutic potential of Hsp90 inhibition for the treatment of tauopathies. Specifically, we describe the development of a high-throughput screening approach to identify and rank compounds, and demonstrate the selective elimination of aberrant p-tau species in the brain following treatment with an Hsp90 inhibitor. Additionally, we identify CHIP as an essential component of the Hsp90 chaperone complex that mediates tau degradation, and present evidence to suggest that CHIP functions to identify and sequester neurotoxic tau species. Finally, we discuss recent data identifying an additional mechanism by which CHIP modulates protein triage decisions involving Hsp90. Specifically, CHIP indirectly regulates Hsp90 chaperone activity by modulating steady-state levels of the Hsp90 deacetylase, HDAC6, thus influencing both the acetylation state and function of Hsp90. Thus future research directions will focus on the manipulation of this network to promote degradation of pathogenic tau species in disease.
A Review of the Status of Foam Applications in Enhanced Oil Recovery (2013)

Abstract Foam has been used for controlling gas mobility during injection processes in order to mitigate the adverse effects of low gas viscosity, reservoir heterogeneity and gravity override. In addition, foam has also been employed in near-wellbore production, matrix acidizing stimulation, hydraulic fracturing, gas shut-off and water shut-off. The optimization of these operations requires a good understanding of the physical characteristics of foam and its behavior under reservoir conditions. Despite numerous experimental and theoretical studies on foam and some field applications reported in the literature, there is no comprehensive literature survey detailing the knowledge and experience gained through the application of foam. The aim of this paper is to present a critical review of the literature available on the use of foam injection for enhanced oil recovery. An extensive appraisal of the current status of foam application in EOR methods is a useful way of presenting advantages, shortcomings and limitations of the process as well as supplementary advances. Special attention has been given to the review of new research topics, such as the use of foam as a mobility control agent. Advances in more efficient foaming agents, additives and boosters are discussed. Moreover, in depth analysis of field applications of foam in EOR projects show that the main problems encountered during field-scale foam applications are related to foam stability, foam compatibility, as well as adsorption of the injected chemicals onto the rock surface. To address this, we discuss the evolution of the pilot field application and the reasons for inconsistency between laboratory results and field scale performance.
ChemInform Abstract: SYNTHESES WITH ANHYDRO SUGARS PART 20, PREPARATION OF 2‐AMINO‐1,6‐ANHYDRO‐2‐DEOXY‐BETA‐D‐GLUCOPYRANOSE AND 2‐AMINO‐1,6/3,4‐DIANHYDRO‐2‐DEOXY‐BETA‐D‐GALACTOPYRANOSE (1974)

Abstract Die Dianhydromannopyranose (I) reagiert mit äthanolischem NH 3 zur Glucopyranose (IIa), die bei katalytischer Debenzylierung (IIb) (isoliert als Hydrochlorid, 95% Ausbeute) ergibt.
Assessment of DNA extracted from FTA® cards for use on the Illumina iSelect BeadChip (2009)

We conclude that DNA extracted from FTA cards by the GenSolve kit is of sufficiently high quality to produce results comparable to those obtained from DNA extracted from whole blood when assayed by the Illumina iSelect technology. Additionally, we validate the use of nasal swabs as an alternative to venous blood or buccal samples from animal subjects for reliably producing high quality genotypes on this platform.
Progression of rheumatoid arthritis following bone marrow transplantation. A case report with a 13‐year followup (1996)

The progression of rheumatoid arthritis (RA) is documented in a patient receiving a sex-mismatched, allogeneic bone marrow transplant (BMT) for gold-induced marrow aplasia. DNA typing confirmed a high probability of a full donor engraftment (complete chimerism). Although the RA was in complete remission 2 years post-BMT, clinical, laboratory, histologic, and radiologic evidence of the recurrence of synovitis from 3-13 years post-BMT is presented. Implications of these observations for theories of the pathogenesis of RA and the future of immunotherapies are discussed.
Improving community awareness in software forges by semantical aggregation of tools feeds (2008)

It is rather difficult to monitor or visualize what can be the contribution of a member in a project, especially when the project uses multiple tools to produce its results. This is the case for collaborative development of FLOSS software, that use Wiki, bug tracker, mailing lists and source code management tools. This paper presents an approach to data collection by using aggregation of feeds published by the different tools of a software forge. To allow this aggregation, collected data is semantically reformatted into Semantic Web standards: RDF, DC, DOAP, and FOAF. Resulting data can then be processed, republished or displayed to project members. We implemented this approach in a supervision module that has been integrated into the PicoForge platform. This module is able do draw a live graph of the social community out of the different sources of data, and in turn export semantic feeds for other uses
Variations in the Secretion of Monoclonal Antibodies by Human-Human Hybridomas (1986)

A series of human-human hybridomas derived from a single fusion of UC 729-6 with lymph node lymphocytes were examined for the type and nature of macromolecules synthesized and secreted. One hybrid, VLN3G2, secreted fourfold higher IgG than that present in the cytoplasm over 4 days of growth, while the IgM distribution was opposite to that of IgG. VLN5C7, contrary to VLN3G2, contained several-fold more cytoplasmic IgG as well as IgM than the amounts secreted over the same period of time. Of the secreted IgG and IgM by both of these hybridomas, only the IgG showed immunoreactivity against target A431 cell surface antigen(s). Another hybridoma, termed VLN1H12, secreted immunoreactive IgM against target A431 cells, but no detectable IgG. Cytoplasmic proteins prepared by repeated freeze-thaw of the hybridoma cells, membrane proteins obtained by NP-40 extraction of the cell membrane, and secreted proteins present in the supernates of the various hybridomas were assayed by an enzyme-linked immunoassay (ELISA), to understand the discrepancy observed in the immunoglobulins of the cellular and extracellular compartments. The parental UC 729-6 cell line used in these cell fusions produced only trace amounts of immunologically inactive IgM and no detectable IgG. Molecular sieving column chromatography of these hybridoma supernates suggested the presence of intact IgG and IgM molecules and the absence of free heavy chains or hybrid antibodies containing both mu and gamma heavy chains. Intrinsic labeling of VLN3G2 hybridoma cells with 35S-methionine demonstrated the presence of not only a nonimmunoglobulin protein but also a small molecular weight protein-A-binding polypeptide in the culture supernatant. 35S-methionine-incorporated IgG and IgM antibodies, isolated from spent media, cytoplasm, and cell membranes of VLN3G2, also showed binding to protein-A-bearing bacteria. In conclusion, the differences observed in the amounts of secreted MAbs by the human-human hybridomas were not due to the decreased synthesis of these molecules.
Insecticidal and Fumigant Activities of <i>Cinnamomum cassia</i> Bark-Derived Materials against <i>Mechoris ursulus </i>(Coleoptera:  Attelabidae) (2000)

The insecticidal and fumigant activities of Cinnamomum cassia (Blume) bark-derived materials against the oak nut weevil (Mechoris ursulus Roelofs) were examined using filter paper diffusion and fumigation methods and compared to those of the commercially available Cinnamomum bark-derived compounds (eugenol, salicylaldehyde, trans-cinnamic acid, and cinnamyl alcohol). The biologically active constituent of the Cinnamomum bark was characterized as trans-cinnamaldehyde by spectroscopic analysis. In a test with the filter paper diffusion method, trans-cinnamaldehyde showed 100 and 83.3% mortality at rates of 2.5 and 1.0 mg/filter paper, respectively. At 2.5 mg/paper, strong insecticidal activity was produced from eugenol (90.0% mortality) and salicylaldehyde (88. 9%), whereas trans-cinnamic acid revealed moderate activity (73.3%). At 5 mg/paper, weak insecticidal activity (50.0%) was produced from cinnamyl alcohol. In a fumigation test, the Cinnamomum bark-derived compounds were much more effective against M. ursulus larvae in closed cups than in open ones. These results indicate that the insecticidal activity of test compounds was attributable to fumigant action, although there is also significant contact toxicity. As a naturally occurring insect-control agent, the Cinnamomum bark-derived materials described could be useful as a new preventive agent against damage caused by M. ursulus.
Performance Testing Support in a Continuous Integration Infrastructure (2017)

The application of continuous integration allows an agile
software development process by automating the build process, so it is
nowadays seen as a good practice. However, if the build process is au-
tomatized, also the testing has to be automatized, to ensure quality and
to detect faults while integrating. One possible quality characteristic of
a software that could be checked is its performance.
In this paper, we propose a performance testing framework for Java that
executes performance tests by using microbenchmarks. It uses the Java
benchmarking toolkit JMH and can test for machine-dependent performance assertions. This framework can be included into the continuous integration server Jenkins, so performance tests will be executed automatically during the build process. We conducted an feasibility evaluation of this approach by applying it to the continuous integration infrastructure
of the Pipe-and-Filter framework TeeTime.
Prtds — a pascal run‐time diagnostics system (1985)

Abstract A run‐time diagnostics system has been described that allows the user to interrogate a program fully in source language terms. In particular, dynamically created data structures are catered for. The diagnostics system allows all objects including those created dynamically to be interrogated and can display a graphical representation of linked data structures. This paper describes the implementation of such a system with the language Pascal on a GEC 4080.