gebhart/patrepeval huggingface dataset:
<i>In Vivo</i> antimalarial activity of aqueous extracts from Kenyan medicinal plants and their Chloroquine (CQ) potentiation effects against a blood‐induced CQ‐resistant rodent parasite in mice (2007)

Hot water extracts from eight medicinal plants representing five families, used for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ) resistant Plasmodium berghei NK65, either alone or in combination with CQ. Extracts of three plants, Toddalia asiatica (root bark), Rhamnus prinoides (leaves and root bark) and Vernonia lasiopus (root bark) showed high chemosuppression in the range 51%-75%. Maytenus acuminata, M. heterophylla, M. senegalensis and Rhamnus staddo had moderate activities of 33%-49% parasitaemia suppression in the root bark and/or leaf extracts, while Withania somnifera (root bark) had a non-significant suppression (21%). In combination with CQ, extracts of V. lasiopus (all parts), leaf extracts of M. senegalensis, R. prinoides and T. asiatica as well as root barks of M. heterophylla, R. staddo and T. asiatica had improved parasitaemia suppression in the range 38%-66%, indicating synergistic interactions. Remarkable parasitaemia suppression by the extracts, either alone or in combination with CQ resulted into longer survival of mice relative to the controls, in some cases by more than 2 weeks. Plants, which showed significant antimalarial activity including V. lasiopus, T. asiatica and R. prinoides, should further be evaluated in the search for novel agents against drug-resistant malaria.
Safety and Pharmacokinetic Profile of Gadobenate Dimeglumine in Subjects With Renal Impairment (1999)

Although mean blood clearance and renal clearance values progressively declined with increasing degree of renal impairment, based on the safety profile and the fact that the administered dose was double the standard dose used for MRI purposes, there appears to be no need for dose reduction in this population.
Enhancing the resolution of CSEM inversion using seismic constraints (2007)

The vertical resolution of inverted CSEM data remains an important issue for its optimal exploitation. In this paper we use a modified simulated annealing (SA) algorithm to remap the inverted CSEM data, in the form of resistivity profiles in depth, into the seismic resolution. Our modification of the SA algorithm solves not only for a best‐fitting model, but also for parameters describing the probability density functions for the resistivity in each layer. This allows us to monitor the uncertainty of our resistivity estimates within the layers. In fact we find that the expected value of the PDF shows better agreement with the well log than the best‐fit model, although the latter has a lower misfit when compared with the surface EM data. In application to the Nuggets‐1 field, we find that the method correctly locates the anomaly associated with the gas sand. The seismic layer is thicker than the gas sand as determined from the well logs, and therefore our estimate of resistivity remains lower than the well log values.
A β <sub>3</sub> Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation (1990)

The ligand-binding function of integrin adhesion receptors depends on divalent cations. A mutant alpha IIb beta 3 integrin (platelet gpIIb/IIIa) that lacks ligand recognition shows immunologic evidence of a perturbed interaction with divalent cations. This was found to be caused by a G----T mutation that resulted in an Asp119----Tyr119 substitution in the beta 3 subunit. This residue is proximal to bound ligand and is in a conserved region among integrins that are enriched in oxygenated residues. The spacing of these residues aligns with the calcium-binding residues in EF hand proteins, suggesting interaction with receptor-bound divalent cation as a mechanism of ligand binding common to all integrins.
Deuterium nuclear magnetic resonance unambiguously quantifies pore and collagen-bound water in cortical bone (2012)

Bone water (BW) plays a pivotal role in nutrient transport and conferring bone with its viscoelastic mechanical properties. BW is partitioned between the pore spaces of the Haversian and lacuno-canalicular system, and water predominantly bound to the matrix proteins (essentially collagen). The general model of BW is that the former predominantly experiences fast isotropic molecular reorientation, whereas water in the bone matrix undergoes slower anisotropic rotational diffusion. Here, we provide direct evidence for the correctness of this model and show that unambiguous quantification in situ of these two functionally and dynamically different BW fractions is possible. The approach chosen relies on nuclear magnetic resonance (NMR) of deuterium ((2) H) that unambiguously separates and quantifies the two fractions on the basis of their distinguishing microdynamic properties. Twenty-four specimens of the human tibial cortex from 6 donors (3 male, 3 female, ages 27-83 years) were cored and (2) H spectra recorded at 62 MHz (9.4 Tesla) on a Bruker Instruments DMX 400 spectrometer after exchange of native BW with (2) H(2) O. Spectra consisted of a doublet signal resulting from quadrupole interaction of water bound to collagen. Doublet splittings were found to depend on the orientation of the osteonal axis with respect to the magnetic field direction (8.2 and 4.3 kHz for parallel and perpendicular orientation, respectively). In contrast, the isotropically reorienting pore-resident water yielded a single resonance line superimposed on the doublet. Nulling of the singlet resonance allowed separation of the two fractions. The results indicate that in human cortical bone 60% to 80% of detectable BW is collagen-bound. Porosity determined as the difference between total BW and collagen bound water fraction was found to strongly parallel micro-computed tomography (µCT)-based measurements (R(2) = 0.91). Our method provides means for direct validation of emerging relaxation-based measurements of cortical bone porosity by proton MRI.
Numerical Taxonomy and Deoxyribonucleic Acid Reassociation in the Taxonomy of Some Gram-Negative Fermentative Bacteria (1974)

One hundred and five strains of gram-negative, fermentative bacteria, representing members of the Enterobacteriaceae together with strains of Vibrio and Aeromonas, were subjected to numerical taxonomy and deoxyribonucleic acid (DNA)/DNA reassociation studies. The numerical taxonomy sorted the strains into major clusters corresponding to Edwardsiella tarda, Escherichia coli, Citrobacter freundii, the tribe Klebsielleae, and Vibrio alginolyticus. Smaller clusters could be identified as Serratia marcescens, Hafnia alvei, and Shigella species. Seven reference strains were used in the DNA/DNA reassociation studies.Klebsiella pneumoniae at 60 C shared reassociation values of 80 to 100% with other strains of Klebsiella, 37 to 64% with Enterobacter spp., and lower values with Hafnia, Citrobacter, Serratia, and Escherichia coli. Phenetically, K. pneumoniae and Enterobacter aerogenes shared high relatedness, although they are only 41 to 64% related in the reassociation studies.Hafnia, Salmonella typhimurium, and Edwardsiella tarda showed little relatedness to any of the other strains included in this study. Both reference strains of Escherichia coli shared genetic resemblances greater than 65% at 60 C with Shigella and at least 70% with other strains of Escherichia coli. Overall, the agreement between numerical taxonomy and the DNA/DNA reassociation studies was satisfactory, with correlation coefficients ranging from 0.5 to 0.9. The choice of reference strains may well affect the correlation between the two techniques, and it is suggested that hypothetical median organisms be determined from the phenetic groupings and that actual strains that approximate to the hypothetical median organisms be used as reference strains for DNA reassociation.
PCM NTSC Television Characteristics (1976)

A tutorial review of the pulse-code-modulated (PCM) NTSC signal characteristics is given including: (1) basic data rate of television images; (2) the color encoder-decoder or codec; (3) PCM encoding rates and phase relative to the color subcarrier; (4) quantizing errors; and (5) the bit rates for practical television systems. These matters are presently being considered by various committees who will promulgate digital standards for the television industry.
Identifying and Managing Hibernating Myocardium: What’s New and What Remains Unknown? (2018)

Hibernation is an adaptive process that promotes myocyte survival over maintaining contractile function. It is innate to mammalian physiology, sharing features with physiological hibernation in other species. Advanced imaging methods have reasonable accuracy in identifying hibernating myocardium. Novel superior hybrid methods may provide diagnostic potential. New evidence supports the role of surgical revascularisation in ischaemic heart failure, but the role of viability tests in planning such procedures remains unclear. Research to date has exclusively involved patients with ambulatory heart failure: Investigating the role of hibernation in ADHF is a key avenue for the future. Whilst our understanding of hibernation pathophysiology has improved dramatically, the clinical utility of identifying and targeting hibernation remains unclear.
Limitations of Applying Summary Results of Clinical Trials to Individual Patients (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multiuser channel estimation for detection of cochannel signals (2003)

Estimation of the channel impulse responses of multiple cochannel users is a key requirement of all multiuser detection and interference cancellation techniques, though little attention has been paid to subject in the context of TDMA systems. This paper addresses a pilot-based technique for multiuser channel estimation in a TDMA system, and makes several new contributions: it allows for time variation of the channels within and between training sequences, it accounts for colouration of the sampled noise sequence as well as correlation between the channel taps, and it considers users to be asynchronous resulting in a technique whereby explicit timing recovery is unnecessary. In addition, it addresses selection of appropriate training sequences.
The <i>Saccharomyces cerevisiae YAK1</i> Gene Encodes a Protein Kinase That Is Induced by Arrest Early in the Cell Cycle (1991)

Null mutations in the gene YAK1, which encodes a protein with sequence homology to known protein kinases, suppress the cell cycle arrest phenotype of mutants lacking the cyclic AMP-dependent protein kinase (A kinase). That is, loss of the YAK1 protein specifically compensates for loss of the A kinase. Here, we show that the protein encoded by YAK1 has protein kinase activity. Yak1 kinase activity is low during exponential growth but is induced at least 50-fold by arrest of cells prior to the completion of S phase. Induction is not observed by arrest at stages later in the cell cycle. Depending on the arrest regimen, induction can occur either by an increase in Yak1 protein levels or by an increase in Yak1 specific activity. Finally, an increase in Yak1 protein levels causes growth arrest of cells with attenuated A kinase activity. These results suggest that Yak1 acts in a pathway parallel to that of the A kinase to negatively regulate cell proliferation.
The effect of thiamine supplementation on tumour proliferation (2001)

Thiamine deficiency frequently occurs in patients with advanced cancer and therefore thiamine supplementation is used as nutritional support. Thiamine (vitamin B1) is metabolized to thiamine pyrophosphate, the cofactor of transketolase, which is involved in ribose synthesis, necessary for cell replication. Thus, it is important to determine whether the benefits of thiamine supplementation outweigh the risks of tumor proliferation. Using oxythiamine (an irreversible inhibitor of transketolase) and metabolic control analysis (MCA) methods, we measured an in vivo tumour growth control coefficient of 0.9 for the thiamine-transketolase complex in mice with Ehrlich's ascites tumour. Thus, transketolase enzyme and thiamine clearly determine cell proliferation in the Ehrlich's ascites tumour model. This high control coefficient allows us to predict that in advanced tumours, which are commonly thiamine deficient, supplementation of thiamine could significantly increase tumour growth through transketolase activation. The effect of thiamine supplementation on tumour proliferation was demonstrated by in vivo experiments in mice with the ascites tumour. Thiamine supplementation in doses between 12.5 and 250 times the recommended dietary allowance (RDA) for mice were administered starting on day four of tumour inoculation. We observed a high stimulatory effect on tumour growth of 164% compared to controls at a thiamine dose of 25 times the RDA. This growth stimulatory effect was predicted on the basis of correction of the pre-existing level of thiamine deficiency (42%), as assayed by the cofactor/enzyme ratio. Interestingly, at very high overdoses of thiamine, approximately 2500 times the RDA, thiamine supplementation had the opposite effect and caused 10% inhibition of tumour growth. This effect was heightened, resulting in a 36% decrease, when thiamine supplementation was administered from the 7th day prior to tumour inoculation. Our results show that thiamine supplementation sufficient to correct existing thiamine deficiency stimulates tumour proliferation as predicted by MCA. The tumour inhibitory effect at high doses of thiamine is unexplained and merits further study.
A major secretory protein from rat seminal vesicle binds ejaculated spermatozoa (1988)

The rat seminal vesicle produces large amounts of a protein-rich fluid that greatly contributes to semen volume. RSV IV, a protein abundantly secreted from this gland, binds in vitro to rat epididymal spermatozoa. However, there is no evidence that this protein may have an in vivo role as a sperm-coating antigen. We report in this paper that high-molecular-weight RSV IV immunologically related proteins can be detected on ejaculated spermatozoa, but not on epididymal spermatozoa. After incubation of purified RSV IV with ejaculated spermatozoa in freshly recovered semen or with epididymal spermatozoa in a medium containing the coagulating gland secretion, sperm-bound proteins with analogous properties were detected. These results support the hypothesis that RSV IV is modified at ejaculation to an high-molecular-weight, sperm-coating antigen.
Oxidation and Reduction of D-Xylose by Cell-Free Extract of <i>Pichia quercuum</i> (1973)

The fermentation mechanism of the simultaneous production of D-xylonic acid and xylitol from D-xylose by Pichia quercuum was studied by using a cell-free enzyme preparation. Nicotinamide adenine dinucleotide phosphate (NADP)-dependent D-xylose dehydrogenase activity and NADP-dependent D-xylose reductase activity were detected, and the oxido-reduction reaction of D-xylose was able to couple through regeneration of NADP and NADPH to produce D-xylonic acid and xylitol.
On Stabilisation of Parametric Active Contours (2007)

Parametric active contours have been used extensively in computer vision for different tasks like segmentation and tracking. However, all parametric contours are known to suffer from the problem of frequent bunching and spacing out of curve points locally during the curve evolution. In a spline based implementation of active contours, this leads to occasional formation of loops locally, and subsequently the curve blows up due to instabilities. It has been shown earlier that in addition to usual evolution along the normal direction, the curve should also be evolved in the tangential direction for stability purposes. In this paper, we provide a mathematical basis for selecting such a suitable tangential component for stabilisation. We prove the boundedness of the evolved curve in this paper, and provide the physical significance. We demonstrate the usefulness of the proposed method with a number of experiments.
TH‐C‐137‐10: Development of a GPU Research Platform for Automatic Treatment Planning and Adaptive Radiotherapy Re‐Planning (2013)

Purpose: To develop a research platform called SCORE (Super Computing Online Re‐planning Environment) for automatic treatment planning and adaptive radiotherapy re‐planning based on GPU. Methods: Our software is a Graphical User Interface (GUI) based on the Qt framework that allows users to easily and quickly create a new treatment plan based on a reference plan. It consists of several modules, including loading plan and patient geometry from DICOM RT files, automatic and manual rigid registration, deformable registration for contour propagation, previous plan based automatic plan optimization, physician‐driven plan tuning, final dose calculation, and plan exporting in DICOM RT format. For automatic planning, a reference plan is identified from a library of previously delivered plans and it is used to guide the optimization process. For adaptive radiotherapy re‐planning, the original plan of the same patient is used as the reference plan to guide the optimization process to generate a new plan on the new patient geometry defined by either a new CT or Cone‐Beam CT image. All the computation modules have been implemented in CUDA to achieve high efficiency. The results for each step of the workflow can be visualized for review, revision, and approval. Results: SCORE has been well tested and validated for prostate and head/neck cancer cases. The validation was done by comparing SCORE plans against the same plans with re‐calculated dose distributions and DVHs using a commercial planning system. We found that SCORE can generate clinically optimal treatment plans that are realistic and deliverable. The plans can be automatically created in only a few minutes, followed by another few minutes of physician fine‐tuning using an interactive GUI. Conclusion: We have developed a very efficient and user‐friendly GPU‐based research platform that can be used for clinical research on automatic treatment planning and adaptive radiotherapy re‐planning.
Increased urinary excretion of 2-hydroxyestrone but not 16alpha-hydroxyestrone in premenopausal women during a soya diet containing isoflavones. (2000)

Asian diets high in soy are associated with lower risk for breast cancer compared with Western diets. Moreover, higher levels of two putative carcinogenic metabolites of 17beta-estradiol, 4- and 16alpha-hydroxyestrogen, and lower amounts of anticarcinogenic metabolites, 2-hydroxyestrogens, have been associated with greater breast cancer risk. In this study, we tested the hypothesis that consumption of a soya diet containing the weakly estrogenic isoflavones genistein and daidzein may alter the metabolism of 17beta-estradiol to 2- and 16alpha-hydroxylated products. Eight pre-menopausal women were placed on a soya-containing, constant diet in a metabolic unit. The diet provided 400 kilocalories from soymilk and 113-202 mg/day (158 +/- 26 mg/day, mean +/- SD) isoflavones daily for a complete menstrual cycle. After a washout period of 4 months, the subjects consumed the same diet, but with soymilk that contained <4.5 mg/day isoflavones ("isoflavone-free"). Urine samples were collected for 24 h daily for the entire cycle during each soya diet period for the analysis of daidzein, genistein, and 2- and 16alpha-hydroxyestrone. Subjects excreted measurable amounts of daidzein (11.6-39.2 mg/day) and genistein (2.9-18.2 mg/day) during the isoflavone-rich soya diet but not during the isoflavone-free soya diet. The diet rich in isoflavones increased the cycle mean daily urinary excretion of 2-hydroxyestrone (averaged over the entire cycle) from 11.6 +/- 2.06 to 17.0 +/- 2.96 nmol/12-h (P = 0.03), a 47% increase. However, the mean daily excretion of 16alpha-hydroxyestrone did not change (7.0 +/- 1.14 nmol/12-h during the isoflavone-free and 7.7 +/- 1.25 nmol/12-h during the isoflavone-rich diet; P = 0.36). The ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone was higher during the isoflavone-rich soya diet (2.6 +/- 0.34) than during the isoflavone-free diet (2.0 +/- 0.32; P = 0.01), a 27% increase. These results suggest that soya isoflavones increase the metabolism of endogenous estrogens to the protective 2-hydroxylated estrogens in women, and this may play an important role in lowering 17beta-estradiol levels and the long-term risk for breast cancer.
Structural Transition in the Metal-Free Hexamer of Protein-Engineered [B13 Gln] Insulin (1989)

For hexamer formation of native insulin the repulsive potential of six B13 Glu carboxylate groups coming together in the centre is overcome by zinc binding to B10 His. Substitution of Gln for Glu in position B13 by site-directed mutagenesis, i.e. replacement of the repelling carboxylates by amide groups, which are offering H-bonding potential, enhances association and allows a metal-free hexamer to form. Merely upon addition of zinc ions this hexamer undergoes the T6----T3R3 respectively T6----R6 structural transition which in the native 2Zn insulin hexamer is inducible only by additives like inorganic anions or phenolic compounds. [B13 Gln]Insulin hexamers are transformed by phenolic compounds, but not by anions, even in the absence of any metal. The structural transformation of insulin can thus be brought about in two ways: By inorganic ions with the zinc ions as their points of attack, which preexist in the nontransformed hexamer, and by phenol, for which the binding sites close to the B5 histidines come into existence only with the transformation. Therefore transformed and non-transformed hexamers, i.e. molecules with helical and extended B chain N-terminus, must be related in a dynamic equilibrium. Phenol acts as a wedge jamming the structure in the transformed state and trapping the zinc ions. Combination of transformed 2Zn[B13 Gln]insulin and metal-free native insulin in the absence of additives results in a redistribution of the zinc ions in favour of native insulin which is an outcome of the dynamic equilibrium and also demonstrates an influence of B13 charge on metal binding affinity. Transformation of a single subunit in a hexamer would lead to bad contacts.(ABSTRACT TRUNCATED AT 250 WORDS)
Dinuclear Zn-Catalyzed Asymmetric Alkynylation of Unsaturated Aldehydes (2005)

Our recent development of a proline-derived bimetallic catalyst has led to a number of efficient, catalytic, enantioselective transformations. Herein, we report a practical and general alkynylation of aromatic and alpha,beta-unsaturated aldehydes using our zinc catalyst system.