gebhart/patrepeval huggingface dataset:
STEROID METABOLISM IN THE YOLK SAC PLACENTA AND ENDOMETRIUM OF THE TAMMAR WALLABY, MACROPUS EUGENII (1980)

Yolk sac and endometrial tissue were obtained from tammar wallabies between 11 and 25 days after the removal of pouch young. Tissues were examined histologically and steroid-metabolizing enzymes were identified by incubation for 3 h at 37 degrees C in Medium 199 containing labelled steroid precursors. Yolk sac membrane (YSM) incubated with labelled pregnenolone produced a small amount of progesterone and pregnanediols; 80.5 +/- 8.4 (S.E.M.) % of the original substrate remained unmetabolized. Labelled androstenedione was metabolized to 5 alpha-androstane-3,17-dione and androsterone, and only 5.8 +/- 3.8% of the original substrate remained at the end of incubation. Incorporation of androstenedione or dehydroepiandrosterone (DHA) into phenolic compounds was low (0.5 +/- 0.1%). There was no evidence for the enzymes, arylsulphatase or sulphotransferase, in YSM. Endometrial tissue from the same animals metabolized pregnenolone, DHA and androstenedione, converted progesterone to androstenedione, and produced aqueous-soluble steroid conjugates. The results demonstrated that YSM contains enzymes associated predominantly with steroid catabolism and with incipient progesterone synthesis. The findings are discussed in relation to the histological appearance of the tissues and compared with placental steroid synthesis in eutherian mammals.
AUG sequences are required to sustain nonsense-codon-mediated suppression of splicing (2006)

More than 90% of human genes are rich in intronic latent 5' splice sites whose utilization in pre-mRNA splicing would introduce in-frame stop codons into the resultant mRNAs. We have therefore hypothesized that suppression of splicing (SOS) at latent 5' splice sites regulates alternative 5' splice site selection in a way that prevents the production of toxic nonsense mRNAs and verified this idea by showing that the removal of such in-frame stop codons is sufficient to activate latent splicing. Splicing control by SOS requires recognition of the mRNA reading frame, presumably recognizing the start codon sequence. Here we show that AUG sequences are indeed essential for SOS. Although protein translation does not seem to be required for SOS, the first AUG is shown here to be necessary but not sufficient. We further show that latent splicing can be elicited upon treatment with pactamycin-a drug known to block translation by its ability to recognize an RNA fold-but not by treatment with other drugs that inhibit translation through other mechanisms. The effect of pactamycin on SOS is dependent neither on steady-state translation nor on the pioneer round of translation. This effect is found for both transfected and endogenous genes, indicating that SOS is a natural mechanism.
Formation of Drawing-Induced E' Centers in Silica Optical Fibers (1985)

Using an electron spin resonance technique, E' centers have been observed in pure silica optical fibers fabricated under various drawing conditions. The E'-center concentration increases with increasing furnace temperature and drawing velocity. The influences of the temperature and velocity have been studied by considering the diameter and temperature distributions of a preform in the drawing furnace. The analysis indicates that the E' centers are frozen in the optical fibers by a thermal activation process in the furnace. The activation energy for the creation of the E' centers is determined as 3.5±0.5 eV, and the effective recombination density for the decay of the E' center as 6.2×10 -13 . Furthermore, the fictive temperature of the optical fibers is estimated to be more than 2100 K from the E'-center concentration.
3D Head Pose Estimation Based on Scene Flow and Generic Head Model (2012)

Head pose is an important indicator of a person's attention, gestures, and communicative behavior with applications in human computer interaction, multimedia and vision systems. In this paper, we present a novel head pose estimation system by performing head region detection using the Kinect [2], followed by face detection, feature tracking, and finally head pose estimation using an active camera. Ten feature points on the face are defined and tracked by an Active Appearance Model (AAM). We propose to use the scene flow approach to estimate the head pose from 2D video sequences. This estimation is based upon a generic 3D head model through the prior knowledge of the head shape and the geometric relationship between the 2D images and a 3D generic model. We have tested our head pose estimation algorithm with various cameras at various distances in real time. The experiments demonstrate the feasibility and advantages of our system.
Increased expression of theMRP5 gene is associated with exposure to platinum drugs in lung cancer (2000)

To investigate the role of the multidrug resistance-associated protein (MRP1) homologue MRP5 in relation to platinum drug resistance, we examined the steady-state levels of the mRNAs for MRP5 in both lung cancer cell lines and peripheral mononuclear cells (PMN) after exposure to platinum drug and in normal lung and lung cancer tissue specimens. Firstly, we examined MRP5 gene expression levels in 80 autopsy samples (40 primary tumors and 40 corresponding normal lung tissues) from 40 patients who had died from lung cancer. Next, we monitored MRP5 gene expression levels within 24 hr in both lung cancer cell lines incubated with cisplatin and in PMN from 10 previously untreated lung cancer patients after carboplatin administration alone. The MRP5 gene expression levels were assessed by quantitative reverse transcription polymerase chain reaction or RNase protection assay. The MRP5 expression levels in normal lung tissues and in tumors from patients exposed to platinum drugs during their lifetime were significantly higher than those in tissues from non-exposed patients. On the other hand, the MRP5 expression levels were not rapidly induced by platinum drugs either in lung cancer cell lines or in PMN within 24 hr. Our results suggest that increased expression levels of the MRP5 gene are associated with exposure to platinum drugs in lung cancer in vivo and/or the chronic stress response to xenobiotics.
Embryo Transfer through the Wall of the Fallopian Tube in Mice (1992)

Two-cell mouse embryos obtained by in vitro fertilization were transferred into the ampulla of the fallopian tubes of pseudopregnant recipients through the wall of the tubes on day 1 of pseudopregnancy. A total of 112 embryos were transferred to 7 pseudopregnant recipients and 68 young (60.7%) were born.
Palm stearin as low trans hard stock for margarine (2010)

Formulation models of brick margarine prepared from the interesterified of a fully hydrogenated palm stearin (POS) and palm kernel oil (PKO), POS of low iodine values and sunflower oil (SFO) were characterised, physically and chemically. Formulations with low trans fatty acid content were used in the margarine preparation and the products were evaluated for 25 days at storage temperatures of 5, 10 and 15oC. The study had shown that formulations of POS in the form of simple blend with PKO and SFO (sample 900), blend of interesterified fully hydrogenated POS with PKO and SFO (sample 905) and simple blend of fully hydrogenated POS with PKO and SFO (sample 904) could achieve similar fatty acid composition, but not SFC profile. The results showed that POS was not only a suitable hard stock in trans-free brick margarine formulations but provided functional property in product texture. The formulations, with saturated fatty acid content < 36% and < 1% trans fatty acid had produced brick margarine with the desired spreadability at refrigerator temperature (5-15oC).
Membrane techniques for treatment in nuclear waste processing: global experience (2008)

Membrane-based processing of nuclear plant radioactive waste products, and radioactive liquids in general, is rapidly gaining acceptance within the nuclear industry. This article focuses on existing information covering the application of membrane technology in the nuclear industry and looks at recent advances, particularly in the field of liquid radioactive waste processing on a pilot scale and plant scale.
Structure-activity relations in psychotomimetic phenylalkylamines (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-activity relations in psychotomimetic phenylalkylaminesF. A. B. Aldous, B. C. Barrass, K. Brewster, D. A. Buxton, D. M. Green, R. M. Pinder, P. Rich, M. Skeels, and K. J. TuttCite this: J. Med. Chem. 1974, 17, 10, 1100–1111Publication Date (Print):October 1, 1974Publication History Published online1 May 2002Published inissue 1 October 1974https://pubs.acs.org/doi/10.1021/jm00256a016https://doi.org/10.1021/jm00256a016research-articleACS PublicationsRequest reuse permissionsArticle Views643Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimal Wireless Aerial Sensor Node Positioning for Randomly Deployed Planar Collaborative Beamforming (2014)

Recent advancements in low power micro sensors and wireless network technology have enabled a host of new sensor network applications. One such novel application is to perform collaborative beamforming from a wireless sensor network consisting of multirotor aerial vehicles (MAVs). Collaborative beamforming from an airborne wireless sensor network can be an effective means of communication from an unobstructed vantage point. This paper explores the feasibility of such a network. We analyze the beam pattern fluctuations due to position errors from the MAV's unsteady station keeping. We show that the effects of minor position errors are manageable. Finally, two non-linear constrained optimization techniques for side lobe suppression utilizing the MAVs mobility and station keeping capability are introduced. We demonstrate through simulation that our techniques have similar performance while requiring lower computational cost and complexity compared to the conventional minimum variance distortion less response beamformer.
A Nonparametric Sequential Test for Online Randomized Experiments (2017)

We propose a nonparametric sequential test that aims to address two practical problems pertinent to online randomized experiments: (i) how to do a hypothesis test for complex metrics; (ii) how to prevent type 1 error inflation under continuous monitoring. The proposed test does not require knowledge of the underlying probability distribution generating the data. We use the bootstrap to estimate the likelihood for blocks of data followed by mixture sequential probability ratio test. We validate this procedure on data from a major online e-commerce website. We show that the proposed test controls type 1 error at any time, has good power, is robust to misspecification in the distribution generating the data, and allows quick inference in online randomized experiments.
Viral Applications of Green Fluorescent Protein (2009)

Over the last ten years, Green Fluorescent Proteins, along with the other spectral variants, have emerged from near obscurity to become a powerful and versatile tool in scientific research. In Viral Applications of Green Fluorescent Protein: Methods and Protocols, leading investigators from around the world contribute detailed examples of both the construction and application of fluorescent proteins delivered by viruses in a format crafted to produce rapid, readily reproducible results. Written in the style of the popular and successful Methods in Molecular Biology™ series, the chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step laboratory protocols, and Notes sections, which highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, Viral Applications of Green Fluorescent Protein: Methods and Protocols supplies researchers with an ideal guide to the many uses of GFP and a vital starting point for future studies utilizing this highly adaptable protein
Fast Dissolving Oral Films: An Innovative Drug Delivery System (2014)

The oral route is most popular route for the administration of therapeutic agents because of the low cost of therapy and ease of administration lead to high levels of patient compliance. The most popular oral solid dosage forms are tablets and capsules. Many patients find it difficult to swallow tablets and hard gelatin capsules particularly pediatric and geriatric patients and do not take their medicines as prescribed. Difficulty in swallowing or dysphasia is seen to afflict nearly 35% of the general population. In some cases such as motion sickness, sudden episode of allergic attack or coughing, fear of choking and an unavailability of water, the swallowing of tablet or capsules may become difficult. To overcome these difficulties, several fast-dissolving drug delivery systems have been developed. Oral fast dissolving film is relatively a new dosage form in which thin film is prepared using hydrophilic polymers, which rapidly dissolves on tongue or buccal cavity. The film overcomes the danger/fear of choking. An ideal film should have the properties like pleasant taste, high stability, ease of handling and administration, no water necessary for application.
The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves (2005)

We conclude that Wallerian degeneration progresses rapidly along individual wild-type axons after a heterogeneous latent phase. The speed of progression and its ability to travel in either direction challenges earlier models in which clearance of trophic or regulatory factors by axonal transport triggers degeneration. WldS axons, once they finally degenerate, do so by a fundamentally different mechanism, indicated by differences in the rate, direction and abruptness of progression, and by different early morphological signs of degeneration. These observations suggest that WldS axons undergo a slow anterograde decay as axonal components are gradually depleted, and do not simply follow the degeneration pathway of wild-type axons at a slower rate.
Medical Management of Carotid Stenosis (2010)

Stroke is a leading cause of morbidity and mortality in the developed world. Although the rates of stroke have decreased in North America, there are significant areas of risk stratification and management that can be improved. Hypertension is the most significant and perhaps most modifiable risk factor for stroke. Carotid atherosclerotic disease is associated with 15% of ischemic strokes. Although carotid endarterectomy (CEA) remains a recommendation for significant symptomatic carotid stenosis, controversy continues in the management of asymptomatic and recurrent carotid stenosis. Medical management options and effectiveness has significantly improved since the early CEA trials were published. Optimal medical management now must incorporate aggressive risk factor reduction measures, particularly with antihyperlipidemic therapy. Improved understanding of the natural history of carotid atherosclerosis is necessary to improve the application of management strategies.
High-speed, 100+W RF switches using GaAs MMICs (1992)

A low-loss, inductive gate bias network structure which allows a very high stacking level of FET devices for high-power RF switching applications is reported. The design, implementation, and performance of S- and C-band SPDT switches based on this structure are described. Multiple GaAs MMIC chips integrated into a suspended-substrate hybrid circuit are used. At S-band, switch risetimes/falltimes of less than 40 ns and an RF power handling capability of 300 W CW have been demonstrated. This input signal level could be maintained during the switch state transitions (hot-switching), while being switched between the two output ports at rates of up to 500 kHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Circulating CD34-Positive Cells Provide an Index of Cerebrovascular Function (2004)

These results suggest a possible contribution of circulating CD34- and CD133-positive cells in maintenance of the cerebral circulation in settings of ischemic stress. Our data demonstrate the utility of a simple and precise method to quantify circulating CD34-positive cells, the latter providing a marker of cerebrovascular function.
Energy-Absorbing Thermoplastics for Head Impact Applications (1996)

<div class="htmlview paragraph">The August 1996 expansion of FMVSS 201 established head impact performance criteria for upper interior components This standard has forced automotive manufacturers, designers, and suppliers to change their thinking for interiors, especially pillars, compliance with FMVSS 201 will require new, structural designs and energy-absorbing materials An ongoing study has examined the implications of FMVSS 201 and its effect on pillars The results of this study have demonstrated how energy-absorbing engineering thermoplastics can be used to meet and exceed the requirements of the head impact legislation through single-piece pillar trims</div>
Cram's introduction to surface electromyography (2011)

A comprehensive resource for your health professions students, including physical and occupational therapists, chiropractors, and behavioral medicine students, Introduction to Surface Electromyography clearly explains how to use SEMG to treat a variety of neuromuscular conditions. It covers the development of SEMG, instrumentation, assessment, and treatment, and features a detailed atlas for electrode placement. * Provides a comprehensive introduction to surface electromyography * Features a detailed electrode atlas with illustrations of 68 electrode placement sites * Includes helpful quick reference items throughout the text * Addresses the growing uses for surface electromyography * Includes data from the latest research studies on the use of SEMG in work performance, sports performance, rehabilitation, and movement analysis
Towards hierarchical cluster based cache coherence for large-scale network-on-chip (2009)

We introduce a novel hierarchical cluster based cache coherence scheme for large-scale NoC based distributed memory architectures. We describe the hierarchical memory organization. We show analytically that the proposed scheme has better performance than traditional counterparts both in memory overhead and communication cost.
A scaled 0.6 μm high speed PLD technology using single-poly EEPROM's (2002)

A 0.6 /spl mu/m CMOS single-polycide, double-metal, EEPROM technology for Programable Logic Device applications is described. A channel-stop implantation through an optimized LOCOS, and a compensated P-well profile at the N+/P junction, results in an aggressive 1.5 /spl mu/m field isolation pitch that satisfies the 12.5 V high-voltage requirement. The FN tunneling currents allow on-chip high-voltage generation from a single power supply for ISP applications. The EPM7032A and EPM7128E PLD products propagation delay time of 4.4 nsec and 6.8 nsec respectively, are the fastest reported at 32 and 128 macro-cell densities.
Changes in electrocardiogram and serum potassium values following glucose ingestion (1969)

Changes in the electrocardiogram, and blood glucose, serum potassium, and serum sodium levels were measured after a standard glucose tolerance test was given to 50 persons; 22 were normal, 18 were diabetic, and 10 had heart disease. A decrease in T-wave amplitude and a lowering of serum potassium level following glucose ingestion was seen in most individuals. However, the degree of change was significantly greater in the group with heart disease than in either the normal or the diabetic group for both T-wave amplitude and serum potassium. The finding that the diabetics more closely resembled the normal group than the group with heart disease with respect to T-wave and potassium changes argues against glucose as the major determinant of these changes; insulin may be the responsible agent.
Serial noninvasive assessment of progressive pulmonary hypertension in a rat model (2002)

Current methods used to investigate pulmonary hypertension in rat models of the disease allow for only one to two measurements of pulmonary artery (PA) pressure in the life of a rat. We investigated whether transthoracic echocardiography can be used to assess the progression of pulmonary hypertension in rats at multiple time points. Serial echocardiographic measurements were performed over a 6-wk period on rats injected with monocrotaline (MCT) or placebo. Development of a midsystolic notch in the PA waveform, a decrease in the PA flow acceleration time (PAAT), an increase in right ventricular (RV) free-wall thickness, and the development of tricuspid regurgitation (TR) were observed as pulmonary hypertension developed. Changes in the PA waveform and PAAT began in week 3 of disease development as the PA systolic pressure (PASP) reached 25-30 mmHg according to right heart catheterization. The RV free-wall thickness increased significantly by week 5 (PASPs 40-50 mmHg). Development of quantifiable TR occurred in week 6 or at PASPs > 65 mmHg. A linear correlation was found between the PAAT and PASP in the range of 30-65 mmHg and between the RV-right atrial pressure gradient (derived from TR velocity) and PASP at pressures >65 mmHg, which enabled a noninvasive estimate of the PASP over a wide range of pressures based on these parameters. These data indicate that transthoracic echocardiography can be used for monitoring the progress of pulmonary hypertension in a rat model.