gebhart/patrepeval huggingface dataset:
Erratum: Entanglement and Tunable Spin-Spin Couplings between Trapped Ions Using Multiple Transverse Modes [Phys. Rev. Lett.<b>103</b>, 120502 (2009).] (2010)

Received 5 August 2010DOI:https://doi.org/10.1103/PhysRevLett.105.109901© 2010 The American Physical Society
Phase II Multicenter Study of Arsenic Trioxide in Patients With Myelodysplastic Syndromes (2006)

Arsenic trioxide monotherapy has moderate activity against MDS, with a manageable adverse effect profile. The further study of arsenic trioxide in MDS, particularly in combination with other agents, is warranted.
New ant i retro viral agents for the therapy of HIV type-1 infection (1993)

A variety of antiretroviral agents are currently under clinical evaluation as anti-HIV-1 therapies. Categorically, these agents differ in the mechanisms by which they inhibit HIV-1 replication and include new, second generation, nucleoside analog reverse transcriptase inhibitors (stavudine, 3TC and FTC), non-nucleoside reverse transcriptase inhibitors (nevirapine, L-697,661 and atevirdine), interferon-cc, viral protease inhibitors (Ro 31-8959 and A77003), and an inhibitor of HIV-1 tat (Ro 5-3335). All of these drugs effectively inhibit HIV-1 replication in cell culture and have shown promise in the inhibition of HIV-1 replication in vivo, either alone or in combination with other antiretroviral agents. Although these agents are currently not approved for general use, it is likely that several will be available as anti-HIV-1 therapies in the near future, pending the outcome of ongoing trials.
Searching for aging‐related proteins in human dermal microvascular endothelial cells treated with anti‐aging agents (2006)

Endothelial cells constitute an interface between blood and tissue and act as a medium for active interaction between plasma and the intracellular environment for homeostasis. Aging of endothelial cells plays a significant role in the pathophysiology of age-related vascular diseases; however, precise mechanisms for senescence have not been elucidated. Proteomics allows identification of protein structures, functions, and characteristics, and can be applied to the study of aging processes. Using cultured human dermal microvascular endothelial cells and two-dimensional proteomic mapping, we studied the effects of kinetin, epigallocatechin-3-gallate, all-trans-retinoic acid, and selenium on their senescence and searched for the aging-related proteins. The treatments resulted in 68 qualitative changes and 172 quantitative changes, and we were able to identify 46 spots among them. All of the agents indicated above induced changes in the expression of moesin, rho guanosine-5'-diphosphate-dissociation inhibitor, and actin, confirmed by immunoblotting and confocal laser microscopy. As these proteins were associated with cell cycle and cytoskeleton, immunoblotting of the proteins related to cell cycle was performed. Although practical significance remains to be confirmed by in vivo research, this fundamental discovery may provide a basis for understanding the mechanism of aging and age-related diseases.
Total Synthesis of the Anti-Apoptotic Agents Iso- and Bongkrekic Acids (2009)

The first convergent total synthesis of isobongkrekic acid is reported involving three different stereospecific palladium cross-couplings for the formation of the diene units. Access to bongkrekic acid by this route is also demonstrated. These syntheses involve the formation of several potentially general building blocks.
Catalysts for Promoting Direct Esterification of Fluoroalcohols (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalysts for Promoting Direct Esterification of FluoroalcoholsP. D. Faurote and J. G. O'RearCite this: Ind. Eng. Chem. 1957, 49, 2, 189–191Publication Date (Print):February 1, 1957Publication History Published online1 May 2002Published inissue 1 February 1957https://pubs.acs.org/doi/10.1021/ie50566a026https://doi.org/10.1021/ie50566a026research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Width-tunable optical RZ pulse train generation based on four-wave mixing in highly nonlinear fiber (2005)

We demonstrate a simple technique for width-tunable optical return-to-zero pulse train generation based on four-wave mixing in highly nonlinear fiber. By electrically tuning the delay between two pump pulse trains, the pulsewidth of a generated pulse train is continuously tuned. In our experiment, the full-width at half-maximum (FWHM) of a 5G pulse train is tuned from 85 to 25 ps, and the FWHM of a 10G pulse train is tuned from 33 to 18 ps. And the simulation results show that the FWHM of a 40G pulse train can be tuned continuously from 10.6 to 2.9 ps. Negligible power penalty is observed after 59-km single-mode fiber and 11.4-km dispersion-compensation-fiber transmission for different pulsewidths at 10 Gb/s.
Development of somatic embryos in Norway spruce (1998)

Embryogenic cell lines of Norway spruce consist of a large number of somatic embryos. The cell lines have been divided into two groups, A and B. The group B embryos are developmentally blocked. Extracts of mature spruce seeds stimulate group B embryos to develop a morphology comparable to group A embryos. However, seed extract inhibits early embryo development. The active components in seed extract were shown probably to be proteins. Extracts of mature seeds contain chitinase-like proteins as recognized by an antibody towards chitinase 4 in sugar beet. Proteins of similar sizes were detected by the same antibody in the conditioned medium of group A, but not in group B. A chitinase 4-related chitinase and a nod factor had a stimulating effect on early embryo development, but did not influence the later stages of embryo development.
Identification of intact glucosinolates using direct coupling of high-performance liquid chromatography with continuous-flow frit fast atom bombardment tandem mass spectrometry (1991)

Intact glucosinolates have been separated and identified in standard mixtures using liquid chromatography (LC) and continuous-flow frit fast atom bombardment tandem mass spectrometry. The separation of individual glucosinolates is achieved by using a conventional-bore LC column with an aqueous ammonium acetate-acetonitrile gradient. The mandatory flow rate reduction is achieved by using a pneumatic splitter. The daughter ion spectra after collision-induced dissociation of the characteristic [M − H]− anion of the glucosinolates yields extensive structure information. Both group- and compound-specific fragments and group-characteristic neutral losses are observed. Strategies for identification of unknown glucosinolates in a mixture from their negative ion tandem mass spectra are indicated.
Lurasidone as a potential therapy for bipolar disorder (2013)

Lurasidone is a benzisothiazol derivative and an atypical antipsychotic approved by the US Food and Drug Administration for the acute treatment of adults with schizophrenia (October 2010) and bipolar 1 depression (June 2013). Lurasidone has a strong antagonistic property at the D2, serotonin (5-HT)2A, and 5-HT7 receptors, and partial agonistic property at the 5-HT1A receptor. Lurasidone also has lower binding affinity for the α2C and 5-HT2C receptor. Lurasidone is rapidly absorbed (time to maximum plasma concentration: 1-3 hours), metabolized mainly by CYP3A4 and eliminated by hepatic metabolism. In two large, well-designed, 6-week trials in adult patients with bipolar 1 depression, lurasidone monotherapy and adjunctive therapy with mood stabilizers were significantly more effective than placebo at improving depressive symptoms assessed using the Montgomery-Åsberg Depression Rating Scale total score. In both trials, lurasidone also reduced the Clinical Global Impression-Bipolar Severity depression score to a greater extent than placebo. In these two trials, discontinuation rates due to adverse events in the lurasidone group were small (<7%) and were not different from those of the placebo group. The most common adverse events in the lurasidone group were headache, nausea, somnolence, and akathisia. The changes in lipid profiles, weight, and parameters of glycemic control were minimal, and these findings were in line with those observed in schizophrenia trials. Further active comparator trials and long-term tolerability and safety data in bipolar patients are required. Lurasidone may be an option for the management of depressive symptoms in patients with bipolar 1 disorder, and it may be considered as a treatment alternative for patients who are at high risk for metabolic abnormalities.
Asymmetric syntheses of 1,6-dialkyl-1,4-cyclohexadiene derivatives (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric syntheses of 1,6-dialkyl-1,4-cyclohexadiene derivativesArthur G. Schultz and Neal J. GreenCite this: J. Am. Chem. Soc. 1991, 113, 13, 4931–4936Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/ja00013a032https://doi.org/10.1021/ja00013a032research-articleACS PublicationsRequest reuse permissionsArticle Views996Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Radical atoms (2012)

research-article Share on Radical atoms: beyond tangible bits, toward transformable materials Authors: Hiroshi Ishii MIT Media Lab MIT Media LabView Profile , Dávid Lakatos MIT Media Lab MIT Media LabView Profile , Leonardo Bonanni MIT Media Lab MIT Media LabView Profile , Jean-Baptiste Labrune MIT Media Lab MIT Media LabView Profile Authors Info & Claims InteractionsVolume 19Issue 1January + February 2012 pp 38–51https://doi.org/10.1145/2065327.2065337Published:01 January 2012Publication History 281citation7,189DownloadsMetricsTotal Citations281Total Downloads7,189Last 12 Months781Last 6 weeks165 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
SiC power-switching devices-the second electronics revolution? (2002)

Silicon carbide (SiC) offers significant advantages for power-switching devices because the critical field for avalanche breakdown is about ten times higher than in silicon. SiC power devices have made remarkable progress in the past five years, demonstrating currents in excess of 100 A and blocking voltages in excess of 19000 V. In this paper we describe the latest progress in three classes of SiC devices: diodes (p-i-n and Schottky), transistors (junction field-effect transistor, metal-oxide-semiconductor field-effect transistor, and bipolar junction transistor), and thyristors (gate turn-off).
Revision of Thermodynamic Data on MnO–Al<sub>2</sub>O<sub>3</sub>Melts (1981)

AbstractAbstractThe high temperature region of the MnO-Al2O3 phase diagram has been redetermined to resolve some discrepancies reported in the literature regarding the melting behaviour of MnAl2O4. This spinel was found to melt congruently at 2108 (± 15)K, The activity of MnO in MnO-Al2O3 melts and in the two phase regions, melt + Mn Al2O4 and MnAl2O4 + Al2O3, has been determined by measuring the manganese concentration in platinum foils in equilibrium under controlled oxygen potentials. The activity of MnO obtained in this study for MnO-Al2O3 melts is in fair agreement with the results of Sharma and Richardson. However, the alumina-rich melt is found to be in equilibrium with Mn Al2O4 rather than Al2O3, as suggested by Sharma and Richardson. The value for the activity of MnO in the Mn Al2O3 + Al2O3 two phase region permits a rigorous application of the Gibbs-Duhem equation for calculating the activity of Al2O3 and the integral Gibbs' energy of mixing of MnO-Al2O3 melts, which are significantly different from those reported in the literature. Résumé Afin de résoudre les divergences rapportées dans la littérature sur le comportement de Mn Al2O4 à la fusion, on a redéterminé la zone des hautes températures du diagramme MnO-Al2O3. On a trouvé que le spinellé Mn Al2O4 présente une fusion congruente à 2108 (+ 15)K. En mesurant la concentration de manganèse dans des feuilles de platine en équilibre avec differents potentiels d'oxygène, on a déterminé l'activité du MnO dans les mélanges fondus MnO-Al2O3 et dans les régions à deux phases: liquide + Mn Al2O4 et Mn Al2O4 + Al2O3 L'activité du MnO obtenue par cette étude est en bon accord avec les résultats de Sharma et Richardson, Cependant on a trouvé que les mélanges riches en alumine sont en équilibre avec Mn Al2O4 plutot qu'avec Al2O3, telquesuggéré par Sharma et Richardson. La valeur de l'activitéde MnO dans la région à deux phases Mn Al2O4 + Al2O3 permet d'appliquer rigoureusement l'équation de Gibbs-Duhem pour calculer l'activité de Al2O3 et l'enthalpie libre de mélange des mélanges MnO-Al2O3, et ces valeurs sont significativement différentes de celles rapportées dans la littérature.
Irradiation Behavior of FBTR Mixed Carbide Fuel at Various Burn-ups (2011)

The Fast Breeder Test Reactor at Kalpakkam has completed nearly 25 years of operation and is now operating at 18 MWt capacity with 46 fuel subassemblies (FSA) in the core consisting of 27 Mark-I (70% PuC + 30% UC), 13 Mark-II (55% PuC + 45% UC) and 6 MOX (44% PuO2 + 56% UO2) and one test PFBR FSA. Post Irradiation Examination (PIE) campaigns on FSAs at different burnup levels has provided valuable information about the irradiation behavior of the carbide fuel. This paper gives a summary of the irradiation performance of the carbide fuel evaluated through some of the investigations such as neutron radiography, X-Radiography, gamma scanning, fission gas analysis and ceramography. Burnup of the carbide fuel could be enhanced from the initial design burnup limit of 50 GWd/t to 165 GWd/ through systematic PIE.
Tantalum-178--a short-lived nuclide for nuclear medicine: development of a potential generator system. (1978)

We describe a chemical separation that may form the basis of a generator system for the short-lived radionuclide Ta-178 (T 1/2 = 9 min). The parent nuclide W-178 (T 1/2 = 21.7 days) is loaded on an anion-exchange column and the daughter eluted with a mixture of dilute hydrochloric acid and hydrogen peroxide. The yields of tantalum and the breakthrough of the tungsten parent as a function of the eluting conditions are discussed, and preliminary animal distribution data are presented for various treatments of the eluant solution.
DNA polymerase I is required for premeiotic DNA replication and sporulation but not for X-ray repair in Saccharomyces cerevisiae. (1989)

We have used a set of seven temperature-sensitive mutants in the DNA polymerase I gene of Saccharomyces cerevisiae to investigate the role of DNA polymerase I in various aspects of DNA synthesis in vivo. Previously, we showed that DNA polymerase I is required for mitotic DNA replication. Here we extend our studies to several stages of meiosis and repair of X-ray-induced damage. We find that sporulation is blocked in all of the DNA polymerase temperature-sensitive mutants and that premeiotic DNA replication does not occur. Commitment to meiotic recombination is only 2% of wild-type levels. Thus, DNA polymerase I is essential for these steps. However, repair of X-ray-induced single-strand breaks is not defective in the DNA polymerase temperature-sensitive mutants, and DNA polymerase I is therefore not essential for repair of such lesions. These results suggest that DNA polymerase II or III or both, the two other nuclear yeast DNA polymerases for which roles have not yet been established, carry out repair in the absence of DNA polymerase I, but that DNA polymerase II and III cannot compensate for loss of DNA polymerase I in meiotic replication and recombination. These results do not, however, rule out essential roles for DNA polymerase II or III or both in addition to that for DNA polymerase I.
Growth of the Maize Primary Root at Low Water Potentials (1990)

Primary roots of maize (Zea mays L. cv WF9 x Mo17) seedlings growing in vermiculite at various water potentials exhibited substantial osmotic adjustment in the growing region. We have assessed quantitatively whether the osmotic adjustment was attributable to increased net solute deposition rates or to slower rates of water deposition associated with reduced volume expansion. Spatial distributions of total osmotica, soluble carbohydrates, potassium, and water were combined with published growth velocity distributions to calculate deposition rate profiles using the continuity equation. Low water potentials had no effect on the rate of total osmoticum deposition per unit length close to the apex, and caused decreased deposition rates in basal regions. However, rates of water deposition decreased more than osmoticum deposition. Consequently, osmoticum deposition rates per unit water volume were increased near the apex and osmotic potentials were lower throughout the growing region. Because the stressed roots were thinner, osmotic adjustment occurred without osmoticum accumulation per unit length. The effects of low water potential on hexose deposition were similar to those for total osmotica, and hexose made a major contribution to the osmotic adjustment in middle and basal regions. In contrast, potassium deposition decreased at low water potentials in close parallel with water deposition, and increases in potassium concentration were small. The results show that growth of the maize primary root at low water potentials involves a complex pattern of morphogenic and metabolic events. Although osmotic adjustment is largely the result of a greater inhibition of volume expansion and water deposition than solute deposition, the contrasting behavior of hexose and potassium deposition indicates that the adjustment is a highly regulated process.
1-Ethyl-4-(3-tropanyl)-tetrahydro-1H-1,4-benzodiazepine (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-Ethyl-4-(3-tropanyl)-tetrahydro-1H-1,4-benzodiazepineS. Archer, T. R. Lewis, M. J. Unser, J. O. Hoppe, and H. LapeCite this: J. Am. Chem. Soc. 1957, 79, 21, 5783–5785Publication Date (Print):November 1, 1957Publication History Published online1 May 2002Published inissue 1 November 1957https://pubs.acs.org/doi/10.1021/ja01578a052https://doi.org/10.1021/ja01578a052research-articleACS PublicationsRequest reuse permissionsArticle Views183Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Discovery of Protein Phosphorylation Motifs through Exploratory Data Analysis (2011)

An iterative algorithm proposed here uses exploratory data analysis to discover motifs from phosphorylated data. The effectiveness of F-Motif has been demonstrated using several real data sets as well as using a synthetic data set. The method is quite general in nature and can be used to find other types of motifs also. We have also provided a server for F-Motif at http://f-motif.classcloud.org/, http://bio.classcloud.org/f-motif/ or http://ymu.classcloud.org/f-motif/.
Performance optimization of an external enhancement resonator for optical second-harmonic generation (2002)

We study the factors that ultimately limit the performance of an external enhancement resonator for optical second-harmonic generation (SHG). To describe the resonant SHG process we introduce a theoretical model that accounts for the intensity-dependent cavity loss that is due to harmonic generation and that also includes a realistic assumption about the shape and the frequency width of the laser mode. With the help of this model we optimized the performance of a doubling cavity based on a lithium triborate (LBO) crystal. This cavity was used for frequency doubling the output of a single-frequency titanium-doped sapphire laser at 850 nm. We were able to push the total second-harmonic conversion efficiency to 53% (a 1.54-W pump resulted in 820 mW of second-harmonic light), which to our knowledge is the best result ever reported for a LBO-based doubling cavity.
Transform coding by lateral inhibited neural nets (2002)

One of the most popular encoding techniques for sensor data is transform coding. This encoding schema is composed of two stages: a linear transformation stage with a nonzero kernel and a vector quantization stage. For the first stage, the author describes a new implementation approach by artifical neural networks. The problem of determining the optimal transformation coefficients is solved by learning the coefficients by a lateral inhibited neural network. After a short introduction to the topic the author focuses on this model and a local stability analysis of the fixpoints for the serial dynamics is provided. The resulting parameter regime is used in a network simulation example using picture statistics. Additionally, the simulations reveal that a biologically-like growing lateral inhibition influence leads to a speed-up of the learning convergence of that model.