gebhart/patrepeval huggingface dataset:
(5<i>S</i>)-2,2,3-Trimethyl-5-(phenylmethyl)-4-imidazolidinone (2016)

[132278-23-2] C13H18N2O (MW 218.29) InChI = 1S/C13H18N2O/c1-13(2)14-11(12(16)15(13)3)9-10-7-5-4-6-8-10/h4-8,11,14H,9H2,1-3H3/t11-/m0/s1 InChIKey = UACYWOJLWBDSHG-NSHDSACASA-N [278173-23-2] C13H18N2O⋅HCl (MW 254.76) InChI = 1S/C13H18N2O.ClH/c1-13(2)14-11(12(16)15(13)3)9-10-7-5-4-6-8-10;/h4-8,11,14H,9H2,1-3H3;1H/t11-;/m0./s1 InChIKey = YIYFEXGDFJLJGM-MERQFXBCSA-N (highly enantioselective organocatalyst for a wide array of asymmetric reactions) Physical Data: imid⋅HCl—colorless crystals; mp 157−161 °C; [ α ] D 20 −64°; c = 1 in H2O. Solubility: imid: ether, MeCN, EtOAc, most organic solvents; imid⋅HCl: sol. H2O, alcohol/H2O mixtures. Form Supplied in: colorless crystals, synthesized from the addition of HCl-dioxane (4 M) to (5S)-2,2,3-trimethyl-5-(phenylmethyl)-4-Imidazolidinone in Et2O. The precipitate was recrystallized from iso-propanaol. Available from Aldrich. Handling, Storage, and Precautions: Store under inert gas in a cool dry place. The salt is hygroscopic, so exposure to moisture should be avoided. Should not be exposed to strong oxidizing agents. Its hazardous decomposition products are carbon monoxide, carbon dioxide, nitrogen oxides, and hydrogen chloride gas.
Lymphoid Neoplasms Associated With IgM Paraprotein A Study of 382 Patients (2005)

We identified 382 consecutive patients with lymphoid neoplasms associated with serum monoclonal IgM paraprotein and classified each neoplasm according to World Health Organization criteria. Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) was most common, 225 cases (median serum IgM level, 2.2 g/dL; range, 0.2–10.9 g/dL). For 157 cases, classification and median (and range in g/dL) IgM levels were as follows: chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL; n = 77), 0.9 (0.1–2.1); marginal zone lymphoma (n = 27), 0.5 (0.1–2.4); follicular lymphoma (n = 18), 0.4 (0.1–1.6); mantle cell lymphoma (n = 11), 0.4 (0.2–1.3); diffuse large B-cell lymphoma (DLBCL; n = 7), 0.5 (0.2–1.0); DLBCL associated with low-grade lymphoma (n = 5), 0.9 (0.4–3.0); angioimmunoblastic T-cell lymphoma (n = 4), 0.8 (0.8); and CD5+CD23–low-grade B-cell lymphoma, unclassified (n = 8), 0.5 (0.3–2.9). The results show IgM paraproteinemia was associated most commonly with LPL/WM (58.9%), followed by CLL/SLL (20.2%). Although serum IgM levels greater than 3 g/dL were restricted to patients with LPL/WM, most patients with LPL/WM had paraprotein levels less than 3 g/dL. Thus, serum IgM paraprotein level is not a reliable discriminator in differential diagnosis.
Spectral analysis of cervical cells using the discrete Fourier transform. (1993)

This paper contains results from a preliminary study of spectral analysis techniques applied to the classification of cervical cells from routinely prepared Papanicolaou cervical smears. Experiments were conducted using a subset of 110 normals and 110 dyskaryotic single cell images randomly selected from a larger cell image data base. An assessment was made of the contribution of different regions within a cell image to the frequency spectrum. Three image sets were used, the original image itself plus two derived from it. In the first derived set, only nuclear size and shape were used. In the second set nuclear morphology and texture were included. Nuclear masking was performed using an interactive segmentation procedure. The discrete Fourier transform was applied to each image in the three image sets and classification experiments were performed using 80 features derived from the frequency spectra. An optimum set of features was selected for each experiment by canonical analysis. Good classification results were obtained when features extracted solely from nuclear shape were used. The inclusion of information relating to nuclear texture improved the results. However, inclusion of the extra nuclear region degraded the classifier's ability to discriminate between cell groups.
Nuclear DNA fragmentation during postnatal tooth development of mouse and hamster and during dentin repair in the rat (1996)

The TUNEL (transferase-mediated, dUTP-biotin nick end labeling) method for in situ labeling of DNA strands was utilized to localize DNA fragmentation in cells involved in tooth formation in the neonatal mouse and hamster. Positive reactions for the presence of DNA fragments were obtained in some epithelial cells of the cervical loop region of incisors, late secretory, transitional and early maturation stage ameloblasts, stratum intermedium cells and in shortened ameloblasts just before eruption. Also, cells of the periodontal ligament of the continuously erupting incisors stained positive shortly before eruption. Odontoblasts were negative but became strongly positive during the formation of physiological osteodentin at the tip of developing incisors. Osteodentin matrix and the surfaces of unerupted enamel and cementum just prior to eruption stained for DNA fragments as well. DNA fragmentation could be elicited in odontoblasts and underlying pulpal tissues of mature erupted molars after mechanical injury to the odontoblast processes during cavity preparation. We conclude that, in rodents, DNA fragmentation and cell death are biological processes which take place in a variety of cells involved in formation of teeth. The TUNEL staining technique is a simple but powerful tool to examine the fate of cells and tissues undergoing either programmed cell death (apoptosis) or fragmentation of nuclear DNA induced by external factors leading to pathological changes.
Tradeoffs in Jet Inlet Design: A Historical Perspective (2007)

The design of the inlet(s) is one of the most demanding tasks of the development process of any gas turbine-powered aircraft. This is mainly due to the multi-objective and multidisciplinary nature of the exercise. The solution is generally a compromise between a number of conflicting goals and these conflicts are the subject of the present paper. We look into how these design tradeoffs have been reflected in the actual inlet designs over the years and how the emphasis has shifted from one driver to another. We also review some of the relevant developments of the jet age in aerodynamics and design and manufacturing technology and we examine how they have influenced and informed inlet design decisions
Simple digital control improving dynamic performance of power factor preregulators (1998)

This paper presents the practical implementation of a fully digital control for boost power factor preregulators (PFPs). The control algorithm, which is simple and fast, provides a significant improvement in the system's dynamic performance compared to the usual analog control techniques. The paper discusses the design criteria and the actions taken for the implementation of the digital control, which is performed by means of a standard microcontroller (Siemens 80C166). The effectiveness of the approach is assessed by experimental tests.
Congenital myotonia in related kittens (1998)

Four closely related domestic shorthair kittens were investigated following the detection of abnormalities in their gait, difficulty opening their mouths and muscle hypertrophy. They walked with a stiff, stilted gait, with the stiffness reducing during exercise. Startling of the kittens resulted in hyperextension of the limbs and falling to lateral recumbency, or spasm of the orbicularis oculi muscle, prolonged prolapse of the nictitating membranes and flattening of the ears. One kitten was intermittently dysphonic. Endotracheal intubation of the anaesthetised kittens was difficult due to an inability to open the mouth to a wide angle, and narrowing of the glottis due to muscle spasm. A diagnosis of congenital myotonia was made based on the clinical signs, the kittens' ages, typical myotonic discharges on electromyography, and the histopathological and histochemical findings in muscle. This is the first report of congenital myotonia in this species.
Synthesis of 1-azaazulene and benz[a]azulene by carbene rearrangement (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 1-azaazulene and benz[a]azulene by carbene rearrangementCurt Wentrup and Juergen BeckerCite this: J. Am. Chem. Soc. 1984, 106, 12, 3705–3706Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://pubs.acs.org/doi/10.1021/ja00324a070https://doi.org/10.1021/ja00324a070research-articleACS PublicationsRequest reuse permissionsArticle Views428Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Specifying the semantics of machine instructions (2002)

Computer architecture manuals describe the instruction set of the machine and the semantics of the machine instructions by a combination of natural language and ISP (Instruction Set Processor) descriptions. The syntax of the instructions in assembly is well defined in the form of tables in the manual. However the semantics is not so well specified and descriptions vary widely from one manual to another. When developing a retargetable binary translator as much as possible needs to be specified in order to automatically generate code from specifications, hence separating machine-independent issues from the manual coding stage. The specification of the semantics of machine instructions is one such task, with the aim of generating suitable code for an intermediate representation that is to be used during the analysis stage. We describe the design process used to develop a semantic specification language, SSL, to integrate into a retargetable binary translation framework. The techniques described herein are suitable not just to binary translators but also to machine-code manipulation tools such as optimizing compilers, binary profilers, instrumentors, and binary debuggers.
Association of TT Virus Primary Infection with Rhinitis in a Newborn (2003)

of tuberculosis disappeared with no evidence of recurrence at 1-year follow-up.
Hyperbolic primary telescope configuration (1984)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Aden B. Meinel, Marjorie P. Meinel, and Ding-Qiang Su, "Hyperbolic primary telescope configuration," Appl. Opt. 23, 2469-2471 (1984) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
SMAD Signaling Regulates CXCL12 Expression in the Bone Marrow Niche, Affecting Homing and Mobilization of Hematopoietic Progenitors (2014)

We recently demonstrated that ex vivo activation of SMAD-independent bone morphogenetic protein 4 (BMP4) signaling in hematopoietic stem/progenitor cells (HSPCs) influences their homing into the bone marrow (BM). Here, we assessed whether alterations in BMP signaling in vivo affects adult hematopoiesis by affecting the BM niche. We demonstrate that systemic inhibition of SMAD-dependent BMP signaling by infusion of the BMP antagonist noggin (NGN) significantly increased CXCL12 levels in BM plasma leading to enhanced homing and engraftment of transplanted HSPCs. Conversely, the infusion of BMP7 but not BMP4, resulted in decreased HSPC homing. Using ST2 cells as an in vitro model of BM niche, we found that incubation with neutralizing anti-BMP4 antibodies, NGN, or dorsomorphin (DM) as well as knockdown of Smad1/5 and Bmp4, all enhanced CXCL12 production. Chromatin immunoprecipitation identified the SMAD-binding element in the CXCL12 promoter to which SMAD4 binds. When deleted, increased CXCL12 promoter activity was observed, and NGN or DM no longer affected Cxcl12 expression. Interestingly, BMP7 infusion resulted in mobilization of only short-term HSCs, likely because BMP7 affected CXCL12 expression only in osteoblasts but not in other niche components. Hence, we describe SMAD-dependent BMP signaling as a novel regulator of CXCL12 production in the BM niche, influencing HSPC homing, engraftment, and mobilization.
Carboxy Terminal Tail of Polycystin-1 Regulates Localization of TSC2 to Repress mTOR (2010)

Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited renal disorder caused by defects in the PKD1 or PKD2 genes. ADPKD is associated with significant morbidity, and is a major underlying cause of end-stage renal failure (ESRF). Commonly, treatment options are limited to the management of hypertension, cardiovascular risk factors, dialysis, and transplantation when ESRF develops, although several new pharmacotherapies, including rapamycin, have shown early promise in animal and human studies. Evidence implicates polycystin-1 (PC-1), the gene product of the PKD1 gene, in regulation of the mTOR pathway. Here we demonstrate a mechanism by which the intracellular, carboxy-terminal tail of polycystin-1 (CP1) regulates mTOR signaling by altering the subcellular localization of the tuberous sclerosis complex 2 (TSC2) tumor suppressor, a gatekeeper for mTOR activity. Phosphorylation of TSC2 at S939 by AKT causes partitioning of TSC2 away from the membrane, its GAP target Rheb, and its activating partner TSC1 to the cytosol via 14-3-3 protein binding. We found that TSC2 and a C-terminal polycystin-1 peptide (CP1) directly interact and that a membrane-tethered CP1 protects TSC2 from AKT phosphorylation at S939, retaining TSC2 at the membrane to inhibit the mTOR pathway. CP1 decreased binding of 14-3-3 proteins to TSC2 and increased the interaction between TSC2 and its activating partner TSC1. Interestingly, while membrane tethering of CP1 was required to activate TSC2 and repress mTOR, the ability of CP1 to inhibit mTOR signaling did not require primary cilia and was independent of AMPK activation. These data identify a unique mechanism for modulation of TSC2 repression of mTOR signaling via membrane retention of this tumor suppressor, and identify PC-1 as a regulator of this downstream component of the PI3K signaling cascade.
Epidemiology of melanoma (2000)

Melanoma incidence and morality rates are increasing in most countries throughout the world where they are being recorded. The annual incidence rates have increased in the order of 3-7% in fair-skinned populations in recent decades. The mortality rates have increased at a rate lower than for incidence. This has been attributed to educational programs designed to improve the early detection of melanoma, as the treatment of melanoma has not changed substantially in recent decades. There has been a decrease in the thickness of melanoma with an increasing proportion of thin melanomas at diagnosis. Causation of melanoma is a combination of constitutional risk factors of which skin colour is the major factor. The presence and number of common acquired and dysplastic melanocytic naevi is also a major constitutional risk factor in fair-skinned people. The only environmental risk factor that has been shown consistently is exposure to sunlight, particularly large doses of sunlight sufficient to cause sunburn in childhood that will be remembered many years later. However, recreational activity leading to sunburn in adulthood is also associated with risk. To date, no other environmental factors have been shown epidemiologically to be clearly associated with risk of melanoma. Recent epidemiological data from some studies suggesting that there is an increased risk of melanoma in sunscreen users requires further explanation.
Revisiting the ALA/N (α-Lipoic Acid/Low-Dose Naltrexone) Protocol for People With Metastatic and Nonmetastatic Pancreatic Cancer: A Report of 3 New Cases (2009)

The authors, in a previous article, described the long-term survival of a man with pancreatic cancer and metastases to the liver, treated with intravenous alpha-lipoic acid and oral low-dose naltrexone (ALA/N) without any adverse effects. He is alive and well 78 months after initial presentation. Three additional pancreatic cancer case studies are presented in this article. At the time of this writing, the first patient, GB, is alive and well 39 months after presenting with adenocarcinoma of the pancreas with metastases to the liver. The second patient, JK, who presented to the clinic with the same diagnosis was treated with the ALA/N protocol and after 5 months of therapy, PET scan demonstrated no evidence of disease. The third patient, RC, in addition to his pancreatic cancer with liver and retroperitoneal metastases, has a history of B-cell lymphoma and prostate adenocarcinoma. After 4 months of the ALA/N protocol his PET scan demonstrated no signs of cancer. In this article, the authors discuss the poly activity of ALA: as an agent that reduces oxidative stress, its ability to stabilize NF(k)B, its ability to stimulate pro-oxidant apoptosic activity, and its discriminative ability to discourage the proliferation of malignant cells. In addition, the ability of lowdose naltrexone to modulate an endogenous immune response is discussed. This is the second article published on the ALA/N protocol and the authors believe the protocol warrants clinical trial.
A Description of the RC2(r) Encryption Algorithm (1998)

This memo is an RSA Laboratories Technical Note.It is meant for informational use by the Internet community.This memo describes a conventional (secret-key) block encryption algorithm, called RC2, which may be considered as a proposal for a DES replacement.The input and output block sizes are 64 bits each.The key size is variable, from one byte up to 128 bytes, although the current implementation uses eight bytes.The algorithm is designed to be easy to implement on 16-bit microprocessors.On an IBM AT, the encryption runs about twice as fast as DES (assuming that key expansion has been done). Algorithm descriptionWe use the term "word" to denote a 16-bit quantity.The symbol + will denote twos-complement addition.The symbol & will denote the bitwise "and" operation.The term XOR will denote the bitwise "exclusive-or" operation.The symbol ˜ will denote bitwise complement.The symbol ^ will denote the exponentiation operation.The term MOD will denote the modulo operation.There are three separate algorithms involved: Key expansion.This takes a (variable-length) input key and produces an expanded key consisting of 64 words K[0],..., K[63].
Type A Behavior and Survival after Acute Myocardial Infarction (1985)

To ascertain the influence of personality factors on the course of coronary artery disease, we measured Type A behavior in 516 patients within two weeks after an acute myocardial infarction, using the Jenkins Activity Survey questionnaire. Over a follow-up period of one to three years, there was no relation between the Type A score and total mortality, cardiac mortality, time to death for nonsurvivors, left ventricular ejection fraction, or duration of the stay in the coronary care unit. These negative findings were not changed by restricting the analyses to men below 61 years of age or by comparing extreme score categories. The contributions of behavioral, demographic, and cardiac physiologic factors to postinfarction mortality were also evaluated by multivariate survivorship analyses. The physiologic factors were the only ones that contributed a significant and independent mortality risk; the Type A score did not enter the survivorship model (relative risk, 0.8; 95 per cent confidence interval, 0.5 to 1.5). Thus, we found no relation between Type A behavior and the long-term outcome of acute myocardial infarction.
Synergistic Nanomedicine: Passive, Active, and Ultrasound-Triggered Drug Delivery in Cancer Treatment (2015)

Nanocarriers are heavily researched as drug delivery vehicles capable of sequestering antineoplastic agents and then releasing their contents at the desired location. The feasibility of using such carriers stems from their ability to produce a multimodel delivery system whereby passive, ligand and triggered targeting can be applied in the fight against cancer. Passive targeting capitalizes on the leaky nature of tumor tissue which allows for the extravasation of particles with a size smaller than 0.5 µm into the tumors. Ligand targeting utilizes the concept of receptor-mediated endocytosis and involves the conjugation of ligands onto the surface of nanoparticles, while triggered targeting involves the use of external and internal stimuli to release the carriers contents upon reaching the diseased location. In this review, micelles and liposomes have been considered due to the promising results they have shown in vivo and in vitro and their potential for advancements into clinical trials. Thus, this review focuses on the most recent advancements in the field of micellar and liposomal drug delivery and considers the synergistic effect of passive- and ligand-targeting strategies, and the use of ultrasound in triggering drug release at the tumor site.
Einleitung (1995)

Unter der formalen Semantik eines Computerprogramms versteht man eine Zusammenfassung dessen, was das Programm bewirkt, in einem oder mehreren mathematischen Objekten. Solche Objekte können zum Beispiel geeignete Funktionen oder Relationen über den Datenbereichen des Programms sein, aber auch Folgen, die die Wirkungsweise eines Computers modellieren, der das Programm ausführt, oder aber logische Ausdrücke, die die Bedeutung des Programms in der Sprache der Logik deutlich machen.
Preparation and characterization of decellularized tendon slices for tendon tissue engineering (2012)

To develop a naturally derived tendon tissue engineering scaffold with the preservation of the native ultrastructure, tensile strength, and biochemical composition of the tendon extracellular matrix (ECM), decellularized tendon slices (DTSs) were prepared using repetitive freeze/thaw of the intact Achilles tendons, frozen section, and nuclease treatment. The DTSs were characterized in the native ultrastructure, mechanical properties, biochemical composition, and cytocompatibility. Histological examination and DNA quantification analysis confirmed that cells were completely removed from tendon tissue by repetitive freeze/thaw in combination with nuclease treatment 12 h. The intrinsic ultrastructure of tendon tissue was well preserved based on scanning electron microscopy examination. The tensile strength of the DTSs was retained 85.62% of native tendon slice. More than 93% of proteoglycans (fibromodulin, biglycan) and growth factors (TGF-β1, IGF-1, VEGF, and CTGF) inherent in tendon ECM were preserved in the DTSs according to ELISA analysis. Furthermore, the DTSs facilitated attachment and repopulation of NIH-3T3 fibroblasts in vitro. Overall, the DTSs are sheet scaffolds with a combination of elemental mechanical strength and tendon ECM bioactive factors that may have many potential applications in tendon tissue engineering.