gebhart/patrepeval huggingface dataset:
Blockade of CTLA-4 Enhances Host Resistance to the Intracellular Pathogen, <i>Leishmania donovani</i> (1998)

CTLA-4 has recently been shown to act as a negative regulator of T cell activation. Here we provide evidence that blockade of CTLA-4 can result in enhanced host resistance to an intracellular pathogen. The administration of anti-CTLA-4 mAb 4F10 to BALB/c mice, 1 day following infection with Leishmania donovani, enhanced the frequency of IFN-gamma and IL-4 producing cells in both spleen and liver, and dramatically accelerated the development of a hepatic granulomatous response. The expression of mRNA for the CXC chemokine gammaIP-10 was also elevated above that seen in control Ab treated mice, and was directly correlated with the frequency of IFN-gamma producing cells. In contrast, macrophage inflammatory protein-1alpha (MIP-1alpha) and monocyte chemotactic protein-1 (MCP-1) mRNA levels were unaffected by anti-CTLA-4 treatment, suggesting that CTLA-4 blockade may exert selective effects on chemokine expression. These changes in tissue response and cytokine/chemokine production were accompanied by a 50 to 75% reduction of parasite load in the spleen and liver of anti-CTLA-4-treated animals compared to controls. Furthermore, administration of anti-CTLA-4 mAb 15 days after L. donovani infection, when parasite burden is increasing in both organs, also resulted in enhanced resistance. Thus, these studies indicate a potent immunomodulatory and potentially therapeutic role for interventions targeted at CTLA-4.
Design and Fabrication of a Transportable Vitrification System for Mixed Waste Processing (1995)

The stabilization and disposal of mixed wastes, which contain both hazardous and radioactive materials, is a significant waste management challenge to the DOE complex.
SCH 45752-An inhibitor of calmodulin-sensitive cyclic nucleotide phosphodiesterase activity. (1993)

A highly potent inhibitor of calmodulin-sensitive phosphodiesterase (PDE) activity was isolated from the culture broth of an unidentified fungal isolate, SCF-125. A chemically defined medium was developed for production of this compound. The PDE inhibitor was isolated from the fermentation filtrate by adsorption on a macro-reticular resin and further purified by gel filtration chromatography and reverse-phase HPLC. The major PDE inhibitor was identified as cephalochromin, a bis-naphthopyrone, by spectral data analysis. The compound, SCH 45752, inhibited calmodulin-sensitive PDE activities with IC50 values of 40-47 nM. It inhibited the activities of calmodulin-independent PDE and various protein kinases with higher IC50 values (2-40 microM). SCH 45752 does not appear to be a calmodulin antagonist. Furthermore, SCH 45752 affects smooth muscle contraction at a concentration of 30 microM; it potentiated the relaxing effect of sodium nitroprusside on carotid artery media contracted by histamine. Thus SCH 45752 is one of the most potent inhibitors of calmodulin-sensitive PDE activity known, and it is capable of exerting a pharmacological effect in at least one intact tissue model.
Molecular Beam Deposition of Nanoscale Ionic Liquids in Ultrahigh Vacuum (2010)

We propose a new approach to nanoscience and technology for ionic liquids (ILs): molecular beam deposition of IL in ultrahigh vacuum by using a continuous wave infrared (CW-IR) laser deposition technique. This approach has made it possible to prepare a variety of "nano-IL" with the given composition on the substrate: a nanodroplet, on one hand, the volume of which goes down to 1 aL and, on the other hand, an ultrathin film with a thickness to several 100 nm or less. The result of fractional distillation of a binary mixture of ILs, investigated by nuclear magnetic resonance as well as electrospray ionization time-of-flight mass spectrometry, indicates that this deposition process is based on the thermal evaporation of ILs, and thus this process also can be used as a new purification method of ILs in vacuum. Furthermore, the fabrication of binary mixture droplets of two ILs on the substrate by alternating deposition of two ILs was demonstrated; the homogeneity of the composition was confirmed even for one single droplet by high-spatial-resolution Raman spectroscopy.
Malware detection based on opcode frequency (2016)

Malware is a computer program or a piece of software that is designed to penetrate and detriment computers without owner's permission. There are different malware types such as viruses, rootkits, keyloggers, worms, trojans, spywares, ransomware, backdoors, bots, logic bomb, etc. Volume, Variant and speed of propagation of malwares are increasing every year. Antivirus companies are receiving thousands of malwares on the daily basis, so detection of malwares is complex and time consuming task. There are many malwares detection techniques like signature based detection, behavior based detection and machine learning based techniques, etc. The signatures based detection system fails for new unknown malware. In case of behavior based detection, if the antivirus program identify attempt to change or alter a file or communication over internet then it will generate alarm signal, but still there is a chance of false positive rate. Also the obfuscation and polymorphism techniques are hinderers the malware detection process. In this paper we propose new method to detect malwares based on the frequency of opcodes in the portable executable file. This research applied machine learning algorithm to find false positives, false negatives, true positives and true negatives for malwares and got 96.67 per cent success rate.
Frequency-domain channel tracking for MIMO-OFDM systems, validated with an experimental data in 5.2 GHz wireless channel (2011)

This paper proposes a channel tracking technique for MIMO-OFDM system, in order to solve timing sensitivity issue with the pilot-based Channel Estimator (CE) reported in [1]. The proposed technique exploits the pilot symbols embedded within the OFDM symbol to estimate the MIMO channel coefficients. Then the estimated channel values of the pilot subcarriers, as well as the initial LTF-based channel estimated values are processed to provide a weighting factor, which is used to track the channel coefficients for the entire transmission packet. The performance of the proposed CE is evaluated with the aid of actual captured data. Our performance study considers a Non-LOS indoor environment, where the transmitter and receiver are approximately 15 meters apart, and located in different rooms. Our study shows that the proposed CE successfully mitigates the susceptibility of the original pilot-based CE to the timing synchronization error.
Optical properties of the clearest natural waters (200–800 nm) (1981)

A new UV submersible spectroradiometer has been employed to determine the diffuse attenuation coefficient for irradiance in the clearest natural waters [K(w)(lambda)] with emphasis on the spectral region from 300 to 400 nm. K(w)(lambda) can be related to the inherent optical properties of pure water, in particular the total absorption coefficient a(w)(lambda) and the molecular scattering coefficient b(m)(lambda), by means of equations derived from radiative transfer theory. We present an analysis showing that limiting values of K(w)(lambda) can be estimated from a(w)(lambda) and vice versa. Published a(w)(lambda) data, which show discrepancies much larger than their estimated accuracies, are briefly reviewed and then compared, via our analysis, with K(w)(lambda) data (our own new and previously published data as well as relevant data of others). This comparative analysis and new data allow a consistent and accurate set of optical properties for the clearest natural waters and for pure fresh water and saltwater to be estimated from 300 to 800 nm.
Computerized classification of malignant and benign microcalcifications on mammograms: texture analysis using an artificial neural network (1997)

We investigated the feasibility of using texture features extracted from mammograms to predict whether the presence of microcalcifications is associated with malignant or benign pathology. Eighty-six mammograms from 54 cases (26 benign and 28 malignant) were used as case samples. All lesions had been recommended for surgical biopsy by specialists in breast imaging. A region of interest (ROI) containing the microcalcifications was first corrected for the low-frequency background density variation. Spatial grey level dependence (SGLD) matrices at ten different pixel distances in both the axial and diagonal directions were constructed from the background-corrected ROI. Thirteen texture measures were extracted from each SGLD matrix. Using a stepwise feature selection technique, which maximized the separation of the two class distributions, subsets of texture features were selected from the multi-dimensional feature space. A backpropagation artificial neural network (ANN) classifier was trained and tested with a leave-one-case-out method to recognize the malignant or benign microcalcification clusters. The performance of the ANN was analysed with receiver operating characteristic (ROC) methodology. It was found that a subset of six texture features provided the highest classification accuracy among the feature sets studied. The ANN classifier achieved an area under the ROC curve of 0.88. By setting an appropriate decision threshold, 11 of the 28 benign cases were correctly identified (39% specificity) without missing any malignant cases (100% sensitivity) for patients who had undergone biopsy. This preliminary result indicates that computerized texture analysis can extract mammographic information that is not apparent by visual inspection. The computer-extracted texture information may be used to assist in mammographic interpretation, with the potential to reduce biopsies of benign cases and improve the positive predictive value of mammography.
Metabolism of PER.C6<sup>TM</sup> cells cultivated under fed‐batch conditions at low glucose and glutamine levels (2006)

This is the first study to examine PER.C6 cell glucose/energy and glutamine metabolism with fed-batch cultures at controlled low glutamine, low glucose, and simultaneous low glucose and low glutamine levels. PER.C6(TM) cell metabolism was investigated in serum-free suspension bioreactors at two-liter scale. Control of glucose and/or glutamine concentrations had a significant effect on cellular metabolism leading to an increased efficiency of nutrient utilization, altered byproduct synthesis, while having no effect on cell growth rate. Cultivating cells at a controlled glutamine concentration of 0.25 mM reduced q(Gln) and q(NH(4)(+)) by approximately 30%, q(Ala) 85%, and q(NEAA) 50%. The fed-batch control of glutamine also reduced the overall accumulation of ammonium ion by approximately 50% by minimizing the spontaneous chemical degradation of glutamine. No major impact upon glucose/energy metabolism was observed. Cultivating cells at a glucose concentration of 0.5 mM reduced q(Glc) about 50% and eliminated lactate accumulation. Cells exhibited a fully oxidative metabolism with Y(O(2)/Glc) of approximately 6 mol/mol. However, despite no increase in q(Gln), an increased ammonium ion accumulation and Y(NH(4)(+)/Gln) were also observed. Effective control of lactate and ammonium ion accumulation by PER.C6 cells was achieved using fed-batch with simultaneously controlled glucose and glutamine. A fully oxidative glucose metabolism and a complete elimination of lactate production were obtained. The q(Gln) value was again reduced and, despite an increased q(NH(4)(+)) compared with batch culture, ammonium ion levels were typically lower than corresponding ones in batch cultures, and the accumulation of non-essential amino acids (NEAA) was reduced about 50%. In conclusion, this study shows that PER.C6 cell metabolism can be confined to a state with improved efficiencies of nutrient utilization by cultivating cells in fed-batch at millimolar controlled levels of glucose and glutamine. In addition, PER.C6 cells fall into a minority category of mammalian cell lines for which glutamine plays a minor role in energy metabolism.
Heat-shock response and limitation of tissue necrosis during occlusion/reperfusion in rabbit hearts. (1993)

BACKGROUND Induction of stress proteins, such as heat-shock protein 71 (HSP71), is associated with cardioprotection in isolated ischemic myocardium. We tested this hypothesis in rabbits pretreated with whole-body hyperthermia and then subjected to 30 or 45 minutes of regional coronary occlusion (CO) followed by 3 hours reperfusion (Rep). METHODS AND RESULTS Control rabbits did not undergo whole-body hyperthermia; heat-shocked (HS) rabbits were subjected to whole-body hyperthermia at 42 degrees C for 15 minutes. Rabbits were allowed to recover from whole-body hyperthermia for 24 or 40 hours and were then subjected to CO/Rep. Heart rate and arterial blood pressure were recorded during the experiments. Area of necrosis (tetrazolium staining) was normalized to anatomic risk zone size (microsphere autoradiography). In rabbits treated with whole-body hyperthermia and 24 hours of recovery, infarct size was significantly reduced in HS rabbits compared with control rabbits (41.2 +/- 7.8% versus 23.2 +/- 6.6%; p < or = 0.05; mean +/- SD) after 30 minutes of CO and 3 hours of Rep. Risk zone size was similar for the two experimental groups. In rabbits treated with whole-body hyperthermia and 40 hours of recovery, infarct size was similar for control and HS animals with either 30 or 45 minutes of CO (p = NS) and 3 hours of Rep. Risk zone size and area of necrosis were similar for these experimental groups. Biopsies from ischemic and nonischemic myocardium were obtained from rabbits at 24 and 40 hours after heat shock and control rabbits to verify expression of HSP71; expression was determined by Western blot analysis. CONCLUSIONS Our findings demonstrate a considerable increase in expression of HSP71 in myocardium from hyperthermia-treated rabbits. Infarct size was significantly reduced after 30 minutes of CO and 3 hours of Rep in hearts at 24 but not 40 hours after heat shock compared with control hearts. We conclude that heat shock-induced cardioprotection is transient and delays the onset of irreversible myocardial injury caused by ischemia.
Time-Dependent Behavior and Fracture of Functionally Graded Thermal Barrier Coatings under Thermal Shock (2005)

The thermal fracture and its dependence on time-dependent behavior in functionally graded yttria stabilized zirconia - NiCoCrAlY bond coat alloy thermal barrier coatings was studied. The response of three coating architectures of similar thermal resistance to laser thermal shock tests was considered, experimentally and computationally.
Convenient Reflux Regulator for Laboratory Stills (1930)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvenient Reflux Regulator for Laboratory StillsJohannes H. BruunCite this: Ind. Eng. Chem. Anal. Ed. 1930, 2, 2, 187–188Publication Date (Print):April 1, 1930Publication History Published online1 May 2002Published inissue 1 April 1930https://doi.org/10.1021/ac50070a021RIGHTS & PERMISSIONSArticle Views40Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (256 KB) Get e-Alerts
A software debugging glossary (1982)

This glossary contains 291 definitions of terms dealing with the debugging of computer software. The list includes numerous synonyms, as well as the proper names of debugging systems described in the open literature. Terms and definitions have been obtained from various sources: the software-engineering literature, other software-engineering glossaries, and individual contributions.
Antitumor synergy of CV787, a prostate cancer-specific adenovirus, and paclitaxel and docetaxel. (2001)

CV787, a PSA+ prostate cell-specific adenovirus variant, is currently in Phase I/II clinical trials for the treatment of prostate cancer. We have previously demonstrated that a single administration of CV787 at 1 x 10(11) particle/animal could eliminate established tumors within 6 weeks in nude mouse xenografts (Yu et al., Cancer Res., 59: 4200-4203, 1999). We now demonstrate that CV787-mediated replication-dependent cytotoxicity is synergistic with the chemotherapeutic agents paclitaxel (Taxol) or docetaxel (Taxotere) both in vitro and in vivo. In vitro, cells were pretreated with CV787 24 h before taxane, pretreated with taxane 24 h before CV787, or treated with both agents simultaneously. Cell viability was determined at various time points by 3-[4,5-dimethylthiazole-2-4]-2,5-diphenyl-2H-tetrazolium bromide assay, and virus yield was examined by plaque assay. Addition of taxane to CV787 resulted in a synergistic increase of cytotoxicity toward the human prostate cancer cell line LNCaP, regardless of the timing of administration. There was no reduction in virus replication or specificity of CV787-based cytopathogenicity for prostate cancer cells (approximately 10,000 to 1) with the taxanes. p53 expression was significantly elevated in the cells treated with CV787 and taxane. In vivo, using the PSA+ LNCaP xenograft model of prostate cancer, a single i.v. dose of 1 x 10(8) particles CV787 and docetaxel in combination eliminates large preexistent distant tumors. Toxicity studies do not show a synergistic increase of toxicity of CV787 and taxane. These experiments demonstrate a synergistic antitumor efficacy for CV787 when combined with taxane and demonstrate an in vivo single-dose curative therapeutic index for CV787 of over 1000:1.
Contingency and Serendipity in the Reactions of Fischer Carbene Complexes with Conjugated Triynes (2004)

The first examples of reactions of Fischer carbene complexes with triynes are reported. The regioselectivity of the reaction of the two different alkyne functions in the symmetrical triyne depends on the nature of the substituent of the triyne. Bis-silyl-substituted triynes react at the central alkyne unit, whereas bis-aryl- and bis-alkyl-substituted triynes react at the end alkyne unit. The reaction of a Fischer carbene complex with a phenyl substituent also reacts with a bis-silyl-substituted triyne at the central alkyne unit but gives a furan product rather than the normal phenol product. It was also demonstrated that all three of the alkyne units in conjugated triynes could react in turn with a Fischer carbene complex to give access to trisquinones.
The Role of Intermediaries (2004)

Ferguson, Linda; Milner, Margaret; Snelgrove-Clarke, ErnaEditor(s): Whitney, JoAnne D. PhD, RN, CWCN Author Information
Effect of the Afterglow on the Felting Shrinkage of Wool (1975)

The so-called afterglow area of electric glow discharges, even if it does not emit visible radiation, still contains active particles capable of initiating a multitude of chemical reactions. When wool was exposed to the afterglow of various gases, a considerable amount of shrinkproofing effect (SPE) was observed. Quantitatively the effect was lower than that obtained in the actual glow. However, depending on the reaction variables (power, gaseous media, and reactor design), active particles were found as far as 300 mm downstream of the glow. The effect increases with the power, almost linearly, without an increase in the temperature. Therefore, in contrast to the glow, the afterglow does not singe the yarn at higher power values. These findings supplement our present theory on the species in glow discharges responsible for shrinkproofing wool. Since the electron density of the afterglow is zero, for practical purposes, free radicals and/or activated molecular species must play an important part in this type of shrinkproofing process. The effect caused by the actual glow is the combination of the high-energy electrons, ions, and other nonionic active species. The quantitative contribution of these various particles to the final SPE is still uncertain.
Proprioception Following Anterior Cruciate Ligament Reconstruction (1992)

Injury to the anterior cruciate ligament (ACL) is thought to disrupt joint afferent sensation and result in proprioceptive deficits. This investigation examined proprioception following ACL reconstruction. Using a proprioceptive testing device designed for this study, kinesthetic awareness was assessed by measuring the threshold to detect passive motion in 12 active patients, who were 11 to 26 months post-ACL reconstruction, using arthroscopic patellar tendon autograft ( n =6) or allograft ( n =6) techniques. Results revealed significantly decreased kinesthetic awareness in the ACL reconstructed knee versus the uninvolved knee at the near-terminal range of motion and enhanced kinesthetic awareness in the ACL reconstructed knee with the use of a neoprene orthotic. Kinesthesia was enhanced in the near-terminal range of motion for both the ACL reconstructed knee and the contralateral uninvolved knee. No significant between-group differences were observed with autograft and allograft techniques.
The chemoreceptive neuron MOS transistors (CνMOS): a novel floating-gate device for molecular and chemical sensing (2004)

We propose a novel chemoreceptive neuron MOS transistor (C/spl nu/MOS) with distinctive features that are crucial to molecular sensing system integration. We have fabricated C/spl nu/MOS transistors with generic molecular receptive areas and experimentally demonstrated high sensitivity from channel current changes and large dynamic range from subthreshold slope shifts in sensing polar and electrolytic liquids. Preliminary measurements have validated most of our assumptions about the performance of these devices and have indicated the feasibility in developing a micropower neuromorphic electronic interface based on existing CMOS technology.
Image Compression With Edge-Based Inpainting (2007)

In this paper, image compression utilizing visual redundancy is investigated. Inspired by recent advancements in image inpainting techniques, we propose an image compression framework towards visual quality rather than pixel-wise fidelity. In this framework, an original image is analyzed at the encoder side so that portions of the image are intentionally and automatically skipped. Instead, some information is extracted from these skipped regions and delivered to the decoder as assistant information in the compressed fashion. The delivered assistant information plays a key role in the proposed framework because it guides image inpainting to accurately restore these regions at the decoder side. Moreover, to fully take advantage of the assistant information, a compression-oriented edge-based inpainting algorithm is proposed for image restoration, integrating pixel-wise structure propagation and patch-wise texture synthesis. We also construct a practical system to verify the effectiveness of the compression approach in which edge map serves as assistant information and the edge extraction and region removal approaches are developed accordingly. Evaluations have been made in comparison with baseline JPEG and standard MPEG-4 AVC/H.264 intra-picture coding. Experimental results show that our system achieves up to 44% and 33% bits-savings, respectively, at similar visual quality levels. Our proposed framework is a promising exploration towards future image and video compression.