gebhart/patrepeval huggingface dataset:
SUMO Conjugation to the Matrix Attachment Region-binding Protein, Special AT-rich Sequence-binding Protein-1 (SATB1), Targets SATB1 to Promyelocytic Nuclear Bodies Where It Undergoes Caspase Cleavage (2008)

SATB1 (special AT-rich sequence-binding protein-1) provides a key link between DNA loop organization, chromatin modification/remodeling, and association of transcription factors at matrix attachment regions (MARs). To investigate the role of SATB1 in cellular events, we performed a yeast two-hybrid screen that identified SUMO-1, Ubc9, and protein inhibitor of activated STAT (PIAS) family members as SATB1 interaction partners. These proteins, working in concert, enhanced SUMO conjugation to lysine-744 of SATB1. Overexpression of SUMO or PIAS in Jurkat cells, which express high levels of endogenous SATB1, exhibited enhanced caspase cleavage of this MAR-associating protein. Sumoylation-deficient SATB1 (SATB1(K744R)) failed to display the characteristic caspase cleavage pattern; however, fusion of SUMO in-frame to SATB1(K744R) restored cleavage. A SUMO-independent interaction of inactive caspase-6 and SATB1 was noted. A subset of total cellular SATB1 localized into promyelocytic leukemia nuclear bodies where enhanced SATB1 cleavage was detected subsequent to caspase activation. These results reveal a novel sumoylation-directed caspase cleavage of this key regulatory molecule. The role of regulated proteolysis of SATB1 may be to control transcription in immune cells during normal cell functions or to assist in efficient and rapid clearance of nonfunctional or potentially damaging immune cells.
An optimized video selective encryption algorithm (2017)

The selective encryption is a commonly used encryption method of protecting video information about H.264/AVC. However, ensuring the effectiveness and minimizing the computation cost of the video encryption at the same time are difficult. In this paper, Motion Vector Difference (MVD) and Quantized coefficient (QC) are classified encrypted. It is found that MVD and QC can be selected to encrypt ensure the computational cost of encryption. The experimental results demonstrate that the proposed method of selecting different encryption methods according to the different parameters of quantization can realize that guaranteeing the effectiveness of video encryption with the purpose of saving the encryption cost.
Asymmetric Shaped-Pattern Synthesis for Planar Antenna Arrays (2016)

A procedure to synthesize asymmetrically shaped beam patterns is developed for planar antenna arrays. As it is based on the quasi-analytical method of collapsed distributions, the main advantage of this procedure is the ability to realize a shaped (null-free) region with very low ripple. Smooth and asymmetrically shaped regions can be used for Direction-of-Arrival estimation and subsequently for efficient tracking with a single output (fully analog) beamformer.
Utilization reporting system facilitates physician practice analysis (1985)

Assistant to the Executive Director Family Health Plan of Massachusetts, Inc. Framingham, Massachusetts
A Role for SMN Exon 7 Splicing in the Selective Vulnerability of Motor Neurons in Spinal Muscular Atrophy (2011)

Spinal muscular atrophy (SMA) is an inherited motor neuron disease caused by homozygous loss of the Survival Motor Neuron 1 (SMN1) gene. In the absence of SMN1, inefficient inclusion of exon 7 in transcripts from the nearly identical SMN2 gene results in ubiquitous SMN decrease but selective motor neuron degeneration. Here we investigated whether cell type-specific differences in the efficiency of exon 7 splicing contribute to the vulnerability of SMA motor neurons. We show that normal motor neurons express markedly lower levels of full-length SMN mRNA from SMN2 than do other cells in the spinal cord. This is due to inefficient exon 7 splicing that is intrinsic to motor neurons under normal conditions. We also find that SMN depletion in mammalian cells decreases exon 7 inclusion through a negative feedback loop affecting the splicing of its own mRNA. This mechanism is active in vivo and further decreases the efficiency of exon 7 inclusion specifically in motor neurons of severe-SMA mice. Consistent with expression of lower levels of full-length SMN, we find that SMN-dependent downstream molecular defects are exacerbated in SMA motor neurons. These findings suggest a mechanism to explain the selective vulnerability of motor neurons to loss of SMN1.
Low-Valent Titanium-Mediated Stereoselective Alkylation of Allylic Alcohols (2008)

We have developed low-valent titanium-mediated 1,3-transpositive cross-coupling reactions of acyclic and cyclic allylic alcohols for the stereoselective introduction of ethyl, 2-silylethyl, 2-phenethyl, and alkenyl groups. Cross-coupling of an allylic alcohol with a vinylsilane or styrene derivative is particularly noteworthy, as an efficient cross-selective coupling of two alkenes has been elusive. The stereochemistry of the cross-coupling alkylation is consistent with syn addition/beta-elimination.
Contribution of satellite cells to IGF‐I induced hypertrophy of skeletal muscle (1999)

Insulin-like growth factor I (IGF-I) is critical in promoting growth of skeletal muscle. When IGF-I is introduced into mouse hindlimb muscles by viral-mediated gene transfer, local overexpression of IGF-I produces significant increases in muscle mass and strength compared with untreated controls (Barton-Davis et al. 1998). We have proposed that this functional hypertrophy is primarily owing to the activation of satellite cells which leads to increased muscle regeneration. In order to test if satellite cells are essential in mediating the hypertrophic effects of IGF-I, we used gamma radiation to destroy the proliferative capacity of satellite cells. The right hindlimbs of adult C57BL/6 male mice were subjected to one of the following treatments: (1) 2,500 rad gamma radiation only, (2) viral-mediated gene transfer of IGF-I only, (3) 2,500 rad gamma radiation plus viral-mediated gene transfer of IGF-I, or (4) no intervention as a control. Approximately 4 months after treatment, the extensor digitorum longus muscles (EDL) from both hindlimbs were removed for mechanical and morphological measurements. Treatment with gamma radiation significantly prevented normal growth of the muscle. When combined with IGF-I treatment, approximately half of the IGF-I effect was prevented by gamma radiation treatment. This suggests that the remaining half of IGF-I induced hypertrophy is owing to paracrine/autocrine effects on the adult myofibres. Thus, these data are consistent with a mechanism by which IGF-I induced muscle hypertrophy via a combination of satellite cell activation and increasing protein synthesis in differentiated myofibres.
Fast atom bombardment mass spectrometry of some nonpolar compounds (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFast atom bombardment mass spectrometry of some nonpolar compoundsJack M. Miller and Kesagapillai. BalasanmugamCite this: Anal. Chem. 1989, 61, 11, 1293–1295Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://pubs.acs.org/doi/10.1021/ac00186a022https://doi.org/10.1021/ac00186a022research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vascular Heme Oxygenase-1 Induction Suppresses Microvascular Thrombus Formation In Vivo (2004)

Local induction of HO-1 activity may be of preventive and therapeutic value for clinical disorders with increased risk of thrombotic events.
Population and patient-specific target margins for 4D adaptive radiotherapy to account for intra- and inter-fraction variation in lung tumour position (2006)

In this work, five 4D image-guidance strategies (two population, an offline adaptive and two online strategies) were evaluated that compensated for both inter- and intra-fraction variability such as changes to the baseline tumour position and respiratory pattern. None of the strategies required active motion compensation such as gating or tracking; all strategies simulated a free-breathing-based treatment technique. Online kilovoltage fluoroscopy was acquired for eight patients with lung tumours, and used to construct inter- and intra-fraction tumour position variability models. Planning was performed on a mid-ventilation image acquired from a respiration-correlated CT scan. The blurring effect of tumour position variability was included in the dose calculation by convolution. CTV to PTV margins were calculated for variability in the cranio-caudal direction. A population margin of 9.0 +/- 0.7 mm was required to account for setup error and respiration in the study population without the use of image-guidance. The greatest mean margin reduction was introduced by the offline adaptive strategy. A daily online correction strategy produced a small reduction (1.6 mm) in the mean margin from the offline strategy. Adaptively correcting for an inter-fraction change in the respiratory pattern had little effect on margin size due to most patients having only small daily changes in the respiratory pattern. A daily online correction strategy would be useful for patients who exhibit large variations in the daily mean tumour position, while an offline adaptive strategy is more applicable to patients with less variation.
Outcome Research and Religious Psychotherapies: Where Are We and Where Are We Going? (1993)

The multitude of religious approaches to psychotherapy are rarely evaluated with established outcome research methodology. Factors contributing to the lack of research in this field are discussed. The author offers an integrative foundation for outcome research. State-of-the-art outcome research design components are reviewed and guidelines are offered for conducting outcome research with religious psychotherapies. These are intended to bind such research around a coherent and meaningful program of empirical validation.
PDB Data Curation (2006)

In this paper, we propose two architectures for curating PDB data to improve its quality. The first one, PDB Data Curation System, is developed by adding two parts, Checking Filter and Curation Engine, between User Interface and Database. This architecture supports the basic PDB data curation. The other one, PDB Data Curation System with XCML, is designed for further curation which adds four more parts, PDB-XML, PDB, OODB, Protin-OODB, into the previous one. This architecture uses XCML language to automatically check errors of PDB data that enables PDB data more consistent and accurate. These two tools can be used for cleaning existing PDB files and creating new PDB files. We also show some ideas how to add constraints and assertions with XCML to get better data. In addition, we discuss the data provenance that may affect data accuracy and consistency.
Correction: Psychological Interventions for Patients with Coronary Heart Disease and Their Partners: A Systematic Review (2013)

Objectives: Despite evidence that patients with coronary heart disease (CHD) and their partners report significant psychological distress, and suggestions that involving partners in interventions alleviates such distress, no systematic reviews have examined this. The objective of this study was to systematically review evidence on the effectiveness of psychological interventions for patients with CHD and their partners.
Electron microscopic and hydrodynamic studies of protein A-immunoglobulin G soluble complexes. (1984)

The soluble complexes formed by reacting staphylococcal protein A (SpA) with rabbit immunoglobulin G (IgG) antibodies were characterized by hydrodynamic and electron microscopic methods. In moderate SpA excess, equilibrium mixtures of SpA and rabbit IgG formed four discrete complexes that sedimented at approximately 7, 10, 13, and 15S. The putative complexes were visible by electron microscopy and appeared to contain one, two, three, and approximately five molecules of IgG. Probably because of its elongated shape, SpA was not clearly visible in these mixtures or in control preparations of SpA alone. Both native IgG and IgG modified by cleavage of its single-hinge disulfide bond formed similar complexes on interaction with SpA. It was possible to resolve heterogeneous mixtures of IgG-SpA complexes by using an analytical ultracentrifuge equipped with a photoelectric scanner interfaced to a small computer. The relative concentrations and sedimentation velocities of different complexes in a mixture were determined from computer-generated integral and derivative plots. Both hydrodynamic and electron microscopic methods revealed that the distribution of complexes was sensitive to the IgG to SpA molar ratio. The relative amounts of faster complexes increased as the IgG to SpA molar ratio was increased. Surprisingly, when the IgG to SpA molar ratio was greater than or equal to 2, the complexes were converted into a unique 17S complex. This rather unprecedented transformation was reversible: the addition of excess SpA caused the dissociation of the 17S complex into a mixture of the 7, 10, 13, and 15S structures. The average translational diffusion coefficient of the 17S complex was 2.62 +/- 0.13 Ficks. In the electron microscope, the complex appeared to be exceptionally compact with an average diameter of 287 A. The stoichiometry of the 17S complex, together with sedimentation equilibrium, diffusion, and electron microscopic measurements, indicated that it is composed of four molecules of IgG and two molecules of SpA.
Milk Proteins, Effects of Heat Treatment on Serum Proteins (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMilk Proteins, Effects of Heat Treatment on Serum ProteinsRobert. JennessCite this: J. Agric. Food Chem. 1954, 2, 2, 75–81Publication Date (Print):January 1, 1954Publication History Published online1 May 2002Published inissue 1 January 1954https://pubs.acs.org/doi/10.1021/jf60022a005https://doi.org/10.1021/jf60022a005research-articleACS PublicationsRequest reuse permissionsArticle Views221Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The In Vivo Differentiation of Human Leukocytes into Histiocytes, Fibroblasts and Fat Cells in Subcutaneous Diffusion Chambers (1961)

Abstract Normal human leukocytes were cultivated in millipore diffusion chambers which had been implanted subcutaneously in autologous and homologous subjects. The observations were made over periods of a few days to six weeks. It was found that mature granulocytes underwent disintegration within one to two weeks. Mononuclear leukocytes underwent differentiation into macrophages and "polyblasts" within a few days and by three weeks had assumed the morphologic appearance characteristic of histiocytes and fibroblast-like cells. By four to six weeks extensive fibroblastic proliferation and marked collagen formation was found. In several chambers numerous fat cells were seen. These in vivo studies demonstrate the mesenchymal potential for differentiation possessed by circulating mononuclear leukocytes of adult blood.
Impact of fungal species cultured on outcome in horses with fungal keratitis (2016)

Equine keratomycosis from Fusarium spp. compared to keratomycosis from Aspergillus spp. is not associated with a different clinical outcome.
Reduction of Materialized View Staleness Using Online Updates (1998)

CS-TR-3878 Updating the materialized views stored in data warehouses usually implies making the warehouse unavailable to users. We propose MAUVE, a new algorithm for online incremental view updates that uses timestamps and allows consistent read-only access to the warehouse while it being updated. The algorithm propagates the updates to the views more often than the typical once a day in order to reduce view staleness. We have implemented MAUVE on top of the Informix Universal Server and used a synthetic workload generator to experiment with various update workloads and different view update frequencies. Our results show that, all kinds of update streams benefit from more frequent view updates, instead of just once a day. However, there is a clear maximum for the view update frequency, for which view staleness is minimal. 1
Effective World Modeling: Multisensor Data Fusion Methodology for Automated Driving (2016)

The number of perception sensors on automated vehicles increases due to the increasing number of advanced driver assistance system functions and their increasing complexity. Furthermore, fail-safe systems require redundancy, thereby increasing the number of sensors even further. A one-size-fits-all multisensor data fusion architecture is not realistic due to the enormous diversity in vehicles, sensors and applications. As an alternative, this work presents a methodology that can be used to effectively come up with an implementation to build a consistent model of a vehicle's surroundings. The methodology is accompanied by a software architecture. This combination minimizes the effort required to update the multisensor data fusion system whenever sensors or applications are added or replaced. A series of real-world experiments involving different sensors and algorithms demonstrates the methodology and the software architecture.
An optimised decision tree induction algorithm for real world data domains (2003)

A major weakness of step-wise decision tree (DT) induction algorithms such as ID3 (J.R. Quinlan, 1986) and CHAID (G.V. Kass, 1980) is the lack of a globally optimal search strategy. These algorithms perform a heuristic search which selects the best local attribute/values split for each internal node. No account is taken of the impact on subsequent splits. Once a split is selected, these algorithms have no backtracking mechanism to enable them to change an attribute split. A genetic algorithm (GA) performs a nonlinear search for the optimal or near optimal solution in a pre-defined search space. The paper asserts that GAs are an effective alternative to the step-wise search strategy employed by traditional DT induction algorithms. We present a novel GA based DT induction algorithm that has been applied to three well-known data sets. Results indicate that this algorithm has produced more accurate decision trees.
DNA Binding to Mouse Cells is Mediated by Cell-Surface Molecules: The Role of These DNA-Binding Molecules as Target Antigens in Murine Lupus (1992)

Autoimmunity to a 28-29-kDa cell-surface DNA-binding molecule has previously been described in patients with systemic lupus erythematosus and related autoimmune diseases. This report describes experiments that implicate a similar antigen-antibody system in the evolution of autoimmunity in lupus-prone mice. DNA binding to murine spleen cells was found to be a saturable phenomenon that was inhibited by excess cold DNA and trypsinization. The role of autoimmunity to murine cell-surface DNA-binding molecules in lupus-prone mice (MRL lpr/lpr, MRL +/+, BXSB) was compared to normal mice (BALB/c, C3H.SW) by means of an assay that measured the inhibition of cell-surface DNA binding. Only sera from lupus strains had inhibitory activity and this component was shown to be an IgM autoantibody. Furthermore, we isolated a spontaneously occurring IgM monoclonal antibody from the spleen of an MRL/lpr mouse, which inhibited DNA binding to mouse cells. Time-course studies indicated that young female MRL/lpr mice lacked detectable activity against cell-surface DNA-binding molecules; however, by 8-10 weeks maximal inhibitory activity was observed. This response occurred prior to the development of significant antinuclear antibody activity. With the appearance of overt disease and anti-DNA antibodies, inhibition of DNA-binding activity became undetectable. These findings mirror previous studies on autoimmunity to a cell-surface DNA-binding molecule on human leucocytes, but have the added advantage of permitting the study of the temporal evolution of this inhibitory activity in relation to disease expression.
Stereoselective Synthesis of [1]Benzopyrano[4,3-<i>b</i>]pyrrol-4(3<i>H</i>)-ones through Cycloadditions of Azomethine Ylides with α,β-Unsaturated Esters (1989)

Abstract Cycloadditions of azomethine ylides generated from α-benzylideneamino nitriles bearing a hydroxyl or its O-protected moiety with α,β-unsaturated esters such as dimethyl maleate, fumarate, methyl acrylate, crotonate, methacrylate, and cinnamate lead stereoselectively to 3,3a-trans-3a,9b-cis-3a,9b-dihydro[1]benzopyrano[4,3-b]pyrrole-4(3H)-ones after subsequent lactonization.
Controller and Scheduler Codesign for Feedback Control Over IEEE 802.15.4 Networks (2016)

In this paper, we examine the impact of the scheduling policy on the performance for feedback control over networks based on a hybrid communication protocol, which incorporates both contention-free and contention-based medium access. We investigate the possibilities and limitations of feedback control in the IEEE 802.15.4 specification and state the problem of scheduling when the controller both utilizes the contention-based and guaranteed parts of the protocol. We propose and compare a number of scheduler-controller codesign algorithms that take both the contention-based and guaranteed parts of the protocol into account using an approximation to an infinite horizon linear quadratic cost function. The simulation studies show that a careful codesign of the scheduler-controller results in significant performance gains, when using both online and offline scheduling policies.
The Pineal Gland in Sudden Infant Death Syndrome: Preliminary Observations (1988)

Sudden infant death syndrome (SIDS) affects infants between 1 month and 1 yr of age, has no known cause, and is diagnosed by exclusion of all other causes of death. The primary mechanism of death in SIDS is considered to be irreversible respiratory cessation during sleep. In a small sampling at necropsy we have observed a statistically significant (P less than .005; determined morphometrically) reduction in the anatomic size of the pineal gland in SIDS infants, as compared to age-matched controls. Whether correspondingly altered pineal glandular function is present in SIDS is as yet unanswered.