gebhart/patrepeval huggingface dataset:
The Stereoisomerism of Complex Inorganic Compounds. XIV. Studies upon the Stereochemistry of Saturated Tervalent Nitrogen Compounds<sup>1</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Stereoisomerism of Complex Inorganic Compounds. XIV. Studies upon the Stereochemistry of Saturated Tervalent Nitrogen Compounds1John R. Kuebler Jr. and John C. Bailar Jr.Cite this: J. Am. Chem. Soc. 1952, 74, 14, 3535–3538Publication Date (Print):July 1, 1952Publication History Published online1 May 2002Published inissue 1 July 1952https://pubs.acs.org/doi/10.1021/ja01134a023https://doi.org/10.1021/ja01134a023research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Operating and Sensing Mechanism of Electrolyte-Gated Transistors with Floating Gates: Building a Platform for Amplified Biodetection (2015)

Electrolyte-gated transistors (EGTs) with floating gates (FGs) are an emerging platform for label-free electronic biodetection. Advantages of floating gate EGTs (FG-EGTs) include signal amplification and inherent sensitivity to small voltages, on the order of 10 mV, associated with chemical binding events on the floating gate electrode surface. Here we examine how the performance of these devices depends on their architecture, specifically the relative sizes (areas) of the control gate, the floating gate, and the source–semiconductor–drain channel. The results allow optimization of the geometry for future biodetection studies. Further, using self-assembled monolayer (SAM) chemistry, we also examine the effect of chemisorption on the floating gate on the current voltage (I–V) characteristics. We find the FG-EGTs respond to both interfacial dipoles and capacitance changes and that the I–V behavior can be reasonably predicted with a lumped capacitor model. Overall, this work provides the most detailed picture to date of the operating mechanism of these promising electronic sensing devices.
ChemInform Abstract: Stoichiometric Applications of η<sup>6</sup>‐Arene Ruthenium(II) Complexes in Organic Chemistry (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of a Process for the Acid-Catalyzed Etherification of Glycerine and Isobutene Forming Glycerine Tertiary Butyl Ethers (2002)

Based on the synthesis of glycerine tertiary butyl ethers from glycerine, a process for the technical production of “higher ethers” (diether and triether) was developed. “Higher ethers” can be used as octane boosters for automotive fuel and are a promising alternative to methyl tertiary butyl ether. The new process, which makes it possible to almost completely convert glycerine and isobutene into the desired “higher ethers”, is compared with a process already applied for the production of glycerine ditertiary butyl ether.
Gain and Target Size Effects on Cursor-Positioning Time with a Mouse (2003)

Movement time to align a cursor with targets on a computer screen a mouse was examined across settings of gain and target size. Empirical evidence was sought in light of previous suggestions that performance declines observed at higher gains can be explained by decreased effective cursor resolution, not gain per se. We tested this hypothesis by holding the effective cursor resolution constant while systematically varying gain and target size. Analysis of movement times showed a significant gain effect as a function of target size. Specifically, movement time increased with gain at the smallest target size (i.e. 1.5 mm) but decreased with gain at the largest target size (i.e. 12 mm). These results do not support the no-effect of gain hypothesis and suggest that target size is an important factor in determining the effects of gain on mouse movement performance.
A Nonlinear Mathematical Model of Virus-Tumor-Immune System Interaction: Deterministic and Stochastic Analysis (2009)

Abstract Ongoing research on cancer has indicated that viruses which specifically infect and destroy tumor cells could be used as a therapeutic agent to arrest tumors. Some of these oncolytic viruses had already been tested clinically with success. However, the interaction dynamics between the tumor host, the invading virus and the immune system response is highly nonlinear and complex and, hence, a proper understanding of such dynamics requires involvement of mathematical models. In the present research, we consider a mathematical model of tumor-virus-immune system dynamics. We analyze the basic deterministic model to find out the importance of different host, viral and immune system parameters in controlling the system dynamics. Next we incorporate random noise inherent in any physiological process by extending the deterministic model into a stochastic one. The resulting stochastic model is studied using the mean square stability approach and criteria for stochastic stability is derived in terms of important system parameters. Numerical simulations are performed in support of analytical findings.
Hafnium(IV) Trifluoromethanesulfonate, An Efficient Catalyst for the Friedel–Crafts Acylation and Alkylation Reactions (1995)

Abstract Hafnium(IV) trifluoromethanesulfonate (hafnium(IV) triflate, Hf(OTf)4) was synthesized from hafnium tetrachloride and trifluoromethanesulfonic acid. The triflate thus prepared was found to be effective in the catalytic Friedel–Crafts acylation reactions of various substituted benzenes with acid anhydrides in lithium perchlorate–nitromethane (LiClO4–MeNO2). Lithium perchlorate–nitromethane is an excellent solvent system, and the catalytic activity of the Lewis acid was much improved in this medium. The product was obtained in up to 250000% molar amounts based on the catalyst. Hafnium(IV) triflate was also found to be quite effective in the catalytic Friedel–Crafts alkylation reactions of aromatic compounds with alkyl chlorides. The reactions proceeded smoothly in the presence of 5% molar amount of Hf(OTf)4 and 50% molar amount of LiClO4 by using a slow addition procedure.
Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor (2015)

Aminoacyl-tRNA synthetases (AARSs) catalyze an early step in protein synthesis, but also regulate diverse physiological processes in animal cells. These include angiogenesis, and human threonyl-tRNA synthetase (TARS) represents a potent pro-angiogenic AARS. Angiogenesis stimulation can be blocked by the macrolide antibiotic borrelidin (BN), which exhibits a broad spectrum toxicity that has discouraged deeper investigation. Recently, a less toxic variant (BC194) was identified that potently inhibits angiogenesis. Employing biochemical, cell biological, and biophysical approaches, we demonstrate that the toxicity of BN and its derivatives is linked to its competition with the threonine substrate at the molecular level, which stimulates amino acid starvation and apoptosis. By separating toxicity from the inhibition of angiogenesis, a direct role for TARS in vascular development in the zebrafish could be demonstrated. Bioengineered natural products are thus useful tools in unmasking the cryptic functions of conventional enzymes in the regulation of complex processes in higher metazoans.
INTRA-ARTICULAR VARIATION OF SYNOVIAL CHANGES IN KNEE ARTHRITIS: BIOPSY STUDY COMPARING CHANGES IN PATELLOFEMORAL SYNOVIUM AND THE MEDIAL TIBIOFEMORAL SYNOVIUM (1987)

Variation of synovial changes in the knee joint was studied in 23 patients. Histological features of biopsies taken from the patellofemoral joint synovium were compared with biopsies taken from the synovium of the medial tibiofemoral joint. The patellofemoral compartment showed more fibrosis compared to the medial tibiofemoral compartment where there was more inflammatory cell infiltration, pigmentation, an increase in vascularity, increased fragment deposition and synovial hyperplasia. Multiple biopsy with reference to compartmental localization is likely to give more information than biopsy of a single site.
ERP and application integration (2001)

During the 1990s, companies focused on the adoption of enterprise resource planning (ERP) systems to solve integration problems. However, ERP systems automate core business activities without solving underlying business structures and processes. As a result a number of disparate applications often coexist with ERP systems. To better understand ERP and application integration (AI) problems, this paper proposes to identify, analyse and present the problems of ERP systems, as well as examining new approaches for AI. In doing so, a multi‐choice questionnaire has been designed, and was distributed to ERP specialists over the Internet. Responses show that ERP systems amplified the need for integration, as existing systems have to be incorporated with ERP applications. AI securely incorporates functionality from disparate applications, and has shown to lead to the development of new strategic business solutions for enterprises. The results of the research confirm AI as a new means of system integration that adds value by placing business logic in the applications network, thus creating a more dynamic information systems infrastructure.
Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks (2016)

Analysis of intravascular optical coherence tomography (IVOCT) data has potential for real-time in vivo plaque classification. We developed a processing pipeline on a three-dimensional local region of support for estimation of optical properties of atherosclerotic plaques from coronary artery, IVOCT pullbacks. Using realistic coronary artery disease phantoms, we determined insignificant differences in mean and standard deviation estimates between our pullback analyses and more conventional processing of stationary acquisitions with frame averaging. There was no effect of tissue depth or oblique imaging on pullback parameter estimates. The method's performance was assessed in comparison with observer-defined standards using clinical pullback data. Values (calcium [Formula: see text], lipid [Formula: see text], and fibrous [Formula: see text]) were consistent with previous measurements obtained by other means. Using optical parameters ([Formula: see text], [Formula: see text], [Formula: see text]), we achieved feature space separation of plaque types and classification accuracy of [Formula: see text]. Despite the rapid [Formula: see text] motion and varying incidence angle in pullbacks, the proposed computational pipeline appears to work as well as a more standard "stationary" approach.
In situ self-assembly of gold nanoparticles on hydrophilic and hydrophobic substrates for influenza virus-sensing platform (2017)

Nanomaterials without chemical linkers or physical interactions that reside on a two-dimensional surface are attractive because of their electronic, optical and catalytic properties. An in situ method has been developed to fabricate gold nanoparticle (Au NP) films on different substrates, regardless of whether they are hydrophilic or hydrophobic surfaces, including glass, 96-well polystyrene plates, and polydimethylsiloxane (PDMS). A mixture of sodium formate (HCOONa) and chloroauric acid (HAuCl<sub>4</sub>) solution was used to prepare Au NP films at room temperature. An experimental study of the mechanism revealed that film formation is dependent on surface wettability and inter particle attraction. The as-fabricated Au NP films were further applied to the colorimetric detection of influenza virus. The response to the commercial target, New Caledonia/H1N1/1999 influenza virus, was linear in the range from 10 pg/ml to 10 μg/ml and limit of detection was 50.5 pg/ml. In the presence of clinically isolated influenza A virus (H3N2), the optical density of developed color was dependent on the virus concentration (10-50,000 PFU/ml). The limit of detection of this study was 24.3 PFU/ml, a limit 116 times lower than that of conventional ELISA (2824.3 PFU/ml). The sensitivity was also 500 times greater than that of commercial immunochromatography kits.
Spatial light modulation for improved microscope stereo vision and 3D tracking (2013)

We present a new type of stereo microscopy which can be used for tracking in 3D over an extended depth. The use of Spatial Light Modulators (SLMs) in the Fourier plane of a microscope sample is a common technique in Holographic Optical Tweezers (HOT). This set up is readily transferable from a tweezer system to an imaging system, where the tweezing laser is replaced with a camera. Just as a HOT system can diffract many traps of different types, in the imaging system many different imaging types can be diffracted with the SLM. The type of imaging we have developed is stereo imaging combined with lens correction. This approach has similarities with human vision where each eye has a lens, and it also extends the depth over which we can accurately track particles.
Towards Self-Protecting Enterprise Applications (2007)

Enterprise systems must guarantee high availability and reliability to provide 24/7 services without interruptions and failures. Mechanisms for handling exceptional cases and implementing fault tolerance techniques can reduce failure occurrences, and increase dependability. Most of such mechanisms address major problems that lead to unexpected service termination or crashes, but do not deal with many subtle domain dependent failures that do not necessarily cause service termination or crashes, but result in incorrect results. In this paper, we propose a technique for developing selfprotecting systems. The technique proposed in this paper observes values at relevant program points. When the technique detects a software failure, it uses the collected information to identify the execution contexts that lead to the failure, and automatically enables mechanisms for preventing future occurrences of failures of the same type. Thus, failures do not occur again after the first detection of a failure of the same type.
Neural synchrony-monitoring wireless brain implant for intractable epilepsy neuromodulation (2013)

A validation of a closed-loop system-on-chip (SoC) for epilepsy treatment is presented. A 12mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> 0.13μm CMOS SoC provides the functionality of neural recording, neural stimulation and early seizure detection based on the bivariate phase synchrony estimation algorithm. The SoC can operate in a closed loop, has 64 neural recording and 64 neural stimulation channels, and dissipates 1.4mW and 1.5mW across 64 channels for neural recording and stimulation, respectively. Two in vivo experiments with freely moving rats based on a non-convulsive and convulsive seizure model are presented. The first in vivo experiment validates the results by comparing the output of the SoC with a SIMULINK model of the implant. The second in vivo experiment validates the SoC in early seizure detection and as a closed-loop intractable epilepsy treatment with 80 percent efficacy. Long Evans rats are used for all experiments. All data are cross-validated by a conventional benchtop amplifier.
Desmosomes--dual junctional principles of intra- and supracellular order in epithelial differentiation and tissue formation. (1994)

The cells of most normal and malignantly growing tissues are connected by "adhering junctions", i.e. distinct sites of "homotypic" contact between the plasma membranes of two cells of the same or a similar kind, associated on the cytoplasmic side by a dense plaque at which often bundles of cytoskeletal filaments anchor. Of the various types of adhering junctions desmosomes are characteristic of epithelia and carcinomas but also occur in some other cell types. Their molecular components have recently been identified and characterized by cDNA-cloning and sequencing. Unexpectedly, the molecular complement of desmosomes has been found to show certain differences in different epithelia, with particularly complex patterns in stratified squamous epithelia as well as in tumors and cultured cell lines derived therefrom. In addition, molecular principles important in the assembly of desmosomes and in the specific anchorage of intermediate-sized filaments (IFs) at desmosomal plaques have been elucidated. The possible value of cell type-specific isoforms of desmosomal components as markers for the subtyping of carcinomas and the role of desmosomal cadherins during invasion and metastasis of carcinomas are discussed.
Oncogenic Activation of Pak1-Dependent Pathway of Macropinocytosis Determines BCG Entry into Bladder Cancer Cells (2013)

Bacille Calmette-Guerin (BCG) is an attenuated strain of Mycobacterium bovis that is used widely as a vaccine for tuberculosis and is used as an effective treatment for superficial bladder carcinoma. Despite being the most successful cancer biotherapy, its mechanism of action and response determinants remain obscure. Here, we establish a model system to analyze BCG interaction with bladder cancer cells, using it to show that these cells vary dramatically in their susceptibility to BCG infection. Unexpectedly, the uptake of BCG by bladder cancer cells occurs by macropinocytosis rather than phagocytosis. BCG entry into bladder cancer cells relied upon Rac1, Cdc42, and their effector kinase Pak1. The difference in susceptibility between BCG-permissive and -resistant bladder cancer cells was due to oncogenic activation of signaling pathways that activate macropinocytosis, with phosphoinositide 3-kinase inhibitor activation stimulating BCG uptake independently of Akt. Similarly, activated Ras strongly activated Pak1-dependent uptake of BCG. These results reveal that oncogenic activation of macropinocytosis determines BCG uptake by bladder cancer cells, implying that tumor responsiveness to BCG may be governed by the specific mutations present in the treated cancer cell.
Occupational cadmium exposure in jig solderers. (1986)

The cadmium body burden, blood and urine cadmium concentrations, and renal function were studied in a group of 53 cadmium solderers. The results showed raised blood and urine cadmium concentrations and raised cadmium body burden in all workers (31) with more than five years exposure, with 27 having urine cadmium concentrations in excess of the proposed biological threshold of 10 nmol/mmol creatinine. Renal tubular dysfunction was found in 17 of the subjects with more than five years exposure and in one this was associated with glomerular dysfunction. These data indicate that cadmium body burden and frequency of tubular dysfunction in end users of cadmium may be as high as those found in smelters or production workers. Subjects with tubular dysfunction did not show greatly increased urine cadmium concentrations compared with those without dysfunction, supporting a previous suggestion that tubular dysfunction occurs before the wash out of cadmium from the kidney. At the time of our study, cadmium exposure stopped as cadmium free soldering rods were introduced. Repeat urine samples from 19 subjects, one to two years after exposure ended indicated that there was no further increase in the level of excretion of low molecular weight proteins, perhaps indicating that the tubular proteinuria does not increase or more severe renal dysfunction develop without continuous exposure.
Sistemas de registro en fisioterapia (1996)

espanolIn the course of their hospital stay, the patient's condition is modified either spontaneously or under the effects of therapeutic actions and care. The Physiotherapy Dossier should be able to describe these changes. The objective of this work is to know the group of information that contains The Physiotherapy Dossier. We retrospectively study 60 medical records of discharged patients and analyze the existence of information in the Physiotherapy documents in the following aspects: existence of a dossier in the Clinical Record, proof of identification data, legibility, correspondence of information with the document, assessment and evolution of the patient. espanolEn el curso de su estancia hospitalaria, el estado del paciente se modifica bien espontaneamente o bien bajo los efectos de las acciones terapeuticas y de los cuidados realizados. El Dossier de fisioterapia debe ser capaz de describir estos cambios. El objetivo de este trabajo es conocer el grupo de informacion que contiene El Dossier de fisioterapia. Se estudian retrospectivamente 60 historias clinicas de pacientes dados de alta y se analiza la existencia de informacion en los documentos de Fisioterapia en los siguientes aspectos: existencia de dossier en la Historia Clinica, constancia de los datos de identificacion, legibilidad, correspondencia de la informacion con el documento, valoracion y evolucion del paciente.
Radiolabeled Somatostatin Analogues Therapy in Advanced Neuroendocrine Tumors: A Single Centre Experience (2012)

The aim of this study was to assess the efficacy of PRRT in patients with advanced neuroendocrine tumors (NETs). Patients and Methods. From January 2007 to August 2011, we enrolled 65 patients (m/f 38/27; mean age 65 years, range 33-83) with advanced NETs having enhanced SSTR expression, treated with PRRT. The enhanced expression of SSTR was assessed using (68)Ga-DOTATOC/DOTATATE PET/CT. Among all the enrolled patients, 6 of them were excluded from the present analysis since they voluntarily interrupted treatment. Mean activity/cycle of 2.6 GBq ((90)Y-DOTATOC/DOTATATE) or 6.0 GBq ((177)Lu-DOTATOC/DOTATATE) was administrated intravenously (max 9 cycles). Results. Complete response (CR) was found in 1/59 (2%) patients, partial remission (PR) in 24/59 (40.5%) patients, stable disease (SD) in 24/59 (40.5%), and progression (PD) in 10/59 (17%) patients. The overall tumor response rate (CR + PR) was 42.5%. In 40.5% of patients, the disease could be stabilized. Overall, 49 out of 59 patients had no tumor progression (83%). Twelve patients out of 59 (20%) had grade 2-3 hematological side effects including anemia, thrombocytopenia, and leukopenia. Long-term nephrotoxicity was observed in 3 patients (2 moderate, 1 severe). Conclusions. PRRT is a promising perspective for patients with advanced NETs.