gebhart/patrepeval huggingface dataset:
Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation (2017)

Purpose Improvement of cure rates for patients treated with allogeneic hematopoietic stem-cell transplantation (HSCT) will require efforts to decrease treatment-related mortality from severe viral infections. Adoptively transferred virus-specific T cells (VSTs) generated from eligible, third-party donors could provide broad antiviral protection to recipients of HSCT as an immediately available off-the-shelf product. Patient and Methods We generated a bank of VSTs that recognized five common viral pathogens: Epstein-Barr virus (EBV), adenovirus (AdV), cytomegalovirus (CMV), BK virus (BKV), and human herpesvirus 6 (HHV-6). The VSTs were administered to 38 patients with 45 infections in a phase II clinical trial. Results A single infusion produced a cumulative complete or partial response rate of 92% (95% CI, 78.1% to 98.3%) overall and the following rates by virus: 100% for BKV (n = 16), 94% for CMV (n = 17), 71% for AdV (n = 7), 100% for EBV (n = 2), and 67% for HHV-6 (n = 3). Clinical benefit was achieved in 31 patients treated for one infection and in seven patients treated for multiple coincident infections. Thirteen of 14 patients treated for BKV-associated hemorrhagic cystitis experienced complete resolution of gross hematuria by week 6. Infusions were safe, and only two occurrences of de novo graft-versus host disease (grade 1) were observed. VST tracking by epitope profiling revealed persistence of functional VSTs of third-party origin for up to 12 weeks. Conclusion The use of banked VSTs is a feasible, safe, and effective approach to treat severe and drug-refractory infections after HSCT, including infections from two viruses (BKV and HHV-6) that had never been targeted previously with an off-the-shelf product. Furthermore, the multispecificity of the VSTs ensures extensive antiviral coverage, which facilitates the treatment of patients with multiple infections.
Configuration-design problem solving (1997)

Configuration design spans many problem types that require varying types of knowledge and problem-solving methods. This article investigates the different types of knowledge that are active in configuration design and identifies some of the applicable problem-solving methods. The result is not a full theory of configuration design, but we make some steps in that direction. To clarify configuration design problem solving, the authors provide a useful classification of the field and discuss configuration task variants and some of the major knowledge categories involved.
The Magnetization of Ferromagnetic Colloids (1938)

The magnetization curves of colloidal magnetite (${\mathrm{Fe}}_{3}$${\mathrm{O}}_{4}$) and colloidal siderac ($\ensuremath{\gamma}$-${\mathrm{Fe}}_{2}$${\mathrm{O}}_{3}$) have been determined by a null method for fields from 0 to 400 gauss. The measured curves have been found to agree with a theoretical curve based on the following assumptions: (1) Each colloid particle is a permanent magnet. This assumption is in accord with a prediction of the theory of ferromagnetism that small ferromagnetic particles be single magnetic domains. (2) There exists a distribution in the size of the particle moments similar to the weight distributions which have been found for other colloids. (3) The particles behave as the molecules of a classical paramagnetic gas. On this basis the average particle moment is found to be ${5.2(10)}^{\ensuremath{-}16}$ for the magnetite sol and ${7.4(10)}^{\ensuremath{-}16}$ for the siderac sol. Several other quantities related to the colloids are briefly discussed.
Resource Management for Dynamic MapReduce Clusters in Multicluster Systems (2012)

State-of-the-art MapReduce frameworks such as Hadoop can easily scale up to thousands of machines and to large numbers of users. Nevertheless, some users may require isolated environments to develop their applications and to process their data, which calls for multiple deployments of MR clusters within the same physical infrastructure. In this paper, we design and implement a resource management system to facilitate the on-demand isolated deployment of MapReduce clusters in multicluster systems. Deploying multiple MapReduce clusters enables four types of isolation, with respect to performance, to data management, to fault tolerance, and to versioning. To efficiently manage the underlying physical resources, we propose three provisioning policies for dynamically resizing MapReduce clusters, and we evaluate the performance of our system through experiments on a real multicluster.
SEC Launches Online Investment Adviser Database (2000)

SEC and an association of state securities administrators have formally introduced a Web-based depository of information on investment advisory firms, ushering in a new phase of the digital age for both advisers and investors. new system will enable the firms, which manage more than $18 trillion in assets, and the individuals who represent them to satisfy federal and state registration and notice requirements with one electronic filing and give investors convenient access--free of charge--to detailed information on the advisers' services, fees and disciplinary records. Investment advisers also will be able to pay state filing fees online by approving debits from accounts they set up and fund for that purpose. Phyllis J. Bernstein, director of the AICPA personal financial planning division, said, The efficiencies of electronic filing will help ease the regulatory burden on advisers, who eventually will be able to do all their filings through their office computers. SEC said investment advisers will be able to register themselves and update their information via the new system by early 2001, but their employees will not be able to apply for or renew registrations online until later in the year. Although the National Association of Securities Dealers Regulation, Inc., will operate and maintain the system, it will not have a policy-making role. SEC also is introducing a revised version of form ADV, which investment advisers use to register their firms and their employees with the SEC or with state securities authorities or to amend such registrations. A pilot implementation of the system, known as the Investment Adviser Registration Depository (IARD), ended November 3. More than 100 investment advisory firms of all sizes participated in the pilot program. In September the SEC approved rules and amendments that require most of the approximately 8,000 investment advisory firms registered with it to use the IARD to submit any filings they make after April 2001, as follows: * Advisers managing more than S25 million in assets are required to register with the SEC. * Advisers managing less than $25 million in assets must register with the securities regulator in the state where their principal office is located. (They are not permitted to register with the SEC.) * All advisers in Wyoming, regardless of the asset amount they manage, must register with the SEC because the state has no securities regulator. State-registered advisers will be limited to paper-based registration until their respective states implement the IARD program. After January 1, 2001, advisers who wish to register with the SEC must submit their applications (part 1 of form ADV) electronically through the IARD. Currently registered advisers who want to amend their registrations will be required, through an incremental schedule, to make the transition to electronic filing during the first four months of 2001. …
Notes. Dimethyl Dithiolfurarate and Some copolymerization Reactions (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes. Dimethyl Dithiolfurarate and Some copolymerization ReactionsC Marvel and J PorterCite this: J. Org. Chem. 1959, 24, 1, 137–139Publication Date (Print):January 1, 1959Publication History Published online19 May 2003Published inissue 1 January 1959https://pubs.acs.org/doi/10.1021/jo01083a628https://doi.org/10.1021/jo01083a628research-articleACS PublicationsRequest reuse permissionsArticle Views34Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spectra and lasing properties of Er3+, Yb3+:phosphate glasses (2003)

The effects of Al2O3, Yb2O3, Er2O3 and OH- on spectral properties of P2O5.Na2O.SrO.Al2O3.Yb2O3.Er2O3 erbium phosphate glass were studied. 5, 8, and 13 mol% Al2O3, 4, 5, 6, 7 and 8 mol% Yb2O3 and 0.05, 0.2, and 0:4 mol% Er2O3 were used. It was found that Al2O3 can improve fluorescent lifetime of Er3+ ions, but the integrated absorption cross section of Er3+ ions decreases with the increase of Al2O3 concentration. Evaluating from energy transfer efficiency of Yb3+ to Er3+ and spectral parameters of Yb3+ and Er3+, we conclude that 6 mol% Yb2O3 and 0:4 mol% Er2O3 are needed for LD pumped microchip laser applications. OH- groups in glass affect greatly fluorescent intensity and lifetime of Er3+, Yb3+:phosphate glass. The OH- absorption coefficient at 3000 cm^(-1) should be less than 1 cm^(-1) for laser applications. Pumped with a 2-W, 974-nm InGaAs laser diode, CW laser centered at 1530 nm with slope efficiency of 10:6 % and maximum output of 43 mW was achieved in our 2-mm-thick Er3+, Yb3+:phosphate glass at room temperature.
Development of an overhead crane for remote handling tasks at nuclear facility (2010)

An overhead crane with telescopic motion was developed to transport servo-manipulator for remote handling tasks in the PyRoprocess Integrated inactive DEmonstration facility (PRIDE). The overhead crane consists of a telescope, trolley system, cabling management system, girder and rotation interface. The telescope of the overhead crane was designed as a cylindrical pipe-based tube type in order to increase the bending and twisting rigidity and it has a long extended length and short retracted length. The cabling management system was designed to be compact in size in order to accommodate the changed cable length according to the telescopic motion. All drive modules were designed to have spare modules in order to prepare for emergencies. As design verification process, structural analysis was performed on some important modules. Currently, the overhead crane is installed at a test bay in KAERI, and it is being tested.
Novel Genetic and Phenotypic Heterogeneity in <i>Bordetella bronchiseptica</i> Pertactin (2001)

The Bordetella bronchiseptica outer membrane protein pertactin is believed to function as an adhesin and is an important protective immunogen. Previous sequence analysis of the pertactin gene identified two regions predicted to encode amino acid repeat motifs. Recent studies have documented DNA sequence heterogeneity in both regions. The present study describes additional variants in these regions, which form the basis for six novel pertactin types. Immunoblotting demonstrated phenotypic heterogeneity in pertactin consistent with the predicted combined sizes of the repeat regions. A revised system for classifying B. bronchiseptica pertactin variants is proposed.
Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid (2016)

This study offers proof of concept that select lysosomal network proteins are differentially expressed in cerebrospinal fluid of Parkinson's disease, corticobasal syndrome and progressive supranuclear palsy. Lysosomal network protein analysis could be further developed as a diagnostic fluid biomarker in parkinsonian syndromes.
Intracellular localization and DNA-binding properties of human papillomavirus type 18 E6 protein expressed with a baculovirus vector (1989)

The E6 protein of human papillomavirus type 18 (HPV-18) is a putative zinc-finger protein that is expressed in HPV-18-induced genital neoplasias. We have studied the biochemical properties of E6 protein synthesized in large amounts with a baculovirus expression vector. When E6 protein was synthesized in insect cells infected with an E6-expressing baculovirus, the protein was localized to both nuclear and membrane fractions, with half-lives of 4 and 2 h, respectively. Changing the first five amino acids of E6 did not alter the pattern of cellular localization of the protein but dramatically increased the half-life of the nuclear component to longer than 30 h and increased the half-life of the membrane component to 8 h. Although the baculovirus-expressed E6 protein bound to double-stranded DNA with high affinity, no sequence specificity for HPV-18 DNA was detected.
Friction Reduction Technology for Low Viscosity Engine Oil Compatible with LSPI Prevention Performance (2016)

<div class="section abstract"><div class="htmlview paragraph">Increasing numbers of vehicles equipped with downsized, turbocharged engines have been introduced seeking for better fuel economy. LSPI (low speed pre-ignition), which can damage engine hardware, is a potential risk of the engines. We reported that engine oil formulation affects frequency of LSPI events, and formulating magnesium detergents into oil is a promising option to prevent LSPI events. From the viewpoint of achieving better fuel economy by engine oil, lowering viscosity is being required. However, it causes reduced oil film thickness and will expand boundary lubrication condition regions in some engine parts. Hence, a technology to reduce friction under boundary lubrication becomes important. To establish technology to reduce friction in low viscosity oils while ensuring good LSPI prevention performance, effective use of molybdenum dithio-carbamate (MoDTC) with magnesium detergents was investigated, since MoDTC is known as one of the most effective friction modifiers to reduce friction under boundary lubricating condition. Our friction study revealed that magnesium detergent deteriorates low friction performance of MoDTC. Throughout a series of XPS analyses, we clarified that magnesium detergent scraped poly-phosphate tribofilm derived from zinc dithio-phosphate (ZnDTP) on the sliding surface, which inhibited MoS<sub>2</sub> tribofilm formation, causing high friction. Borated dispersant was formulated to oil to promote formation of harder poly-borophosphate tribofilm which prevents itself from being scraped by magnesium detergent, causing low friction. This formulation technology of engine oil is applicable for future ILSAC GF-6 engine oil and after, where LSPI prevention performance and low viscosity are required for excellent fuel economy.</div></div>
Tyrosine Versus Serine/Threonine Phosphorylation by Protein Kinase Casein Kinase-2 (1999)

Protein kinase casein kinase-2 (CK2) is a spontaneously active, ubiquitous, and pleiotropic enzyme that phosphorylates seryl/threonyl residues specified by multiple negatively charged side chains, the one at position n + 3 being of crucial importance (minimum consensus S/T-x-x-E/D/S(P)/T(P). Recently CK2 has been reported to catalyze phosphorylation of the yeast nucleolar immunophilin Fpr3 at a tyrosyl residue (Tyr(184)) fulfilling the consensus sequence of Ser/Thr substrates (Wilson, L.K., Dhillon, N., Thorner, J., and Martin, G.S. (1997) J. Biol. Chem. 272, 12961-12967). Here we show that, by contrast to other tyrosyl peptides fulfilling the consensus sequence for CK2, a peptide reproducing the sequence around Fpr3 Tyr(184) (DEDADIY(184)DEEDYDL) is phosphorylated by CK2, albeit with much higher K(m) (384 versus 4. 3 microM) and lower V(max) (8.4 versus 1,132 nmol.min(-1).mg(-1)) than its derivative with Tyr(184) replaced by serine. The replacement of Asp at position n + 1 with alanine and, to a lesser extent, of Ile at n - 1 with Asp are especially detrimental to tyrosine phosphorylation as compared with serine phosphorylation, which is actually stimulated by the Ile to Asp modification. In contrast the replacement of Glu at n + 3 with alanine almost suppresses serine phosphorylation but not tyrosine phosphorylation. It can be concluded that CK2 is capable to phosphorylate, under special circumstances, tyrosyl residues, which are specified by structural features partially different from those that optimize Ser/Thr phosphorylation.
Model-based management of embedded service systems-an applied approach (2006)

The automatic integration of devices into dynamic, automatically configured networks alone does not take advantage of the entire potential of service oriented architectures (SOA). Using service management, independent services can be directed to perform meta tasks in a SOA network. In this paper we describe and evaluate the service management tool MOBASEC, which consists of two parts: at system runtime, management services are running in order to enforce management policies. The second part of the tool is a graphical model editor which supports the user in setting up the desired management policies easily. This research is part of the European SIRENA (Service Infrastructure for Real-time Embedded Networked Applications). The use of MOBASEC was evaluated by the project in automotive application and the results are summarized here.
Development of a 3D remote dosimetry protocol compatible with <scp>MR</scp>g<scp>IMRT</scp> (2017)

A novel 3D remote dosimetry protocol is introduced for validating off-site dosimetrically complex radiotherapy systems, including MRgRT. The protocol involves correcting for temporal and spatially dependent changes in PRESAGE<sup>®</sup> radiochromic dosimeters readout by optical-CT. Application of the protocol to TG-119 irradiations enabled verification of MRgRT dose distributions with high resolution.
The Wake of St. Vincent (1997)

The island of St. Vincent and the other Windward Islands in the southeastern Caribbean were chosen as a field site for the study of weak mountain wakes. By the authors' definition, a "weak wake" forms when the potential vorticity generated by a mountain is not strong enough to advect itself into eddies; rather, it is simply advected downstream by the ambient flow. GOES-8 and Landsat sunglint images unambiguously revealed that the mountainous Windward Islands have remarkably long straight wakes. The length of St. Vincent's wake exceeds 300 km although its width is only 20 km. Near the islands, the wake structures reflect the details of the island topography. These wakes do not exhibit any obvious diurnal effect. Boat surveys in the lee of St. Vincent confirmed the existence of features seen in the images: the sharp wake boundary, the small valley-induced jet embedded in the near wake, and the absence of any reverse flow. Aircraft surveys gave evidence of descent over the island and showed that the wake air is relatively warm and dry. The length of the wake (L) agrees with the formula L = H/2CD (where H is the wake depth and CD is the surface drag coefficient), implying that the reacceleration of the wake air is caused by the ambient streamwise pressure gradient rather than by lateral entrainment of momentum or geostrophic adjustment. Two numerical models were used to simulate St. Vincent's wake, a single-layer hydrostatic model and a 3D nonhydrostatic model. Both models indicated that air descent, acceleration, wave breaking, and weak potential vorticity generation occur over the island, causing a long straight wake.
Adenosine A <sub>1</sub> Receptor Activation as a Brake on the Microglial Response after Experimental Traumatic Brain Injury in Mice (2010)

We reported that adenosine A(1) receptor (A(1)AR) knockout (KO) mice develop lethal status epilepticus after experimental traumatic brain injury (TBI), which is not seen in wild-type (WT) mice. Studies in epilepsy, multiple sclerosis, and neuro-oncology suggest enhanced neuro-inflammation and/or neuronal death in A(1)AR KO. We hypothesized that A(1)AR deficiency exacerbates the microglial response and neuronal damage after TBI. A(1)AR KO and WT littermates were subjected to mild controlled cortical impact (3 m/sec; 0.5 mm depth) to left parietal cortex, an injury level below the acute seizure threshold in the KO. At 24 h or 7 days, mice were sacrificed and serial sections prepared. Iba-1 immunostaining was used to quantify microglia at 7 days. To assess neuronal injury, sections were stained with Fluoro-Jade C (FJC) at 24 h to evaluate neuronal death in the hippocampus and cresyl violet staining at 7 days to analyze cortical lesion volumes. We also studied the effects of adenosine receptor agonists and antagonists on (3)H-thymidine uptake (proliferation index) by BV-2 cells (immortalized mouse microglial). There was no neuronal death in CA1 or CA3 quantified by FJC. A(1)AR KO mice exhibited enhanced microglial response; specifically, Iba-1 + microglia were increased 20-50% more in A(1)AR KO versus WT in ipsilateral cortex, CA3, and thalamus, and contralateral cortex, CA1, and thalamus (p < 0.05). However, contusion and cortical volumes did not differ between KO and WT. Pharmacological studies in cultured BV-2 cells indicated that A(1)AR activation inhibits microglial proliferation. A(1)AR activation is an endogenous inhibitor of the microglial response to TBI, likely via inhibition of proliferation, and this may represent a therapeutic avenue to modulate microglia after TBI.
Flexible System Solutions for Innovative Laser Welding Processes (2015)

Abstract The new platform WeldMaster by Precitec provides a large toolset for modern laser welding applications. Sensors and actuators for the pre‐, in‐ and post‐process monitoring and control are implemented, offering the most advanced all‐in‐one system‐solution for laser welding tasks. The customer's benefits are especially valuable in automotive applications, where robustness, efficiency and reliability are highly demanded. The combination with an intelligent welding head allows to improve known applications and to develop trend‐setting joining processes.
A Time-to-Frequency Converter for Measuring Picosecond Optical Pulses (1993)

There are several techniques for directly measuring the shape of short optical pulses, such as detection with photodiodes and streak cameras. Current state of the ait is 1-2 ps time resolution. We report a new technique to measure the pulse width of a 1.064 µm Nd:YAG mode-locked pulse-train with 3 ps resolution. This technique is best described as time-to-frequency conversion: pulse amplitude is uniquely mapped from die time domain to frequency domain such that the pulse shape can be directly measured with a spectrometer. This work further demonstrates the elegant analogy between diffraction and dispersion1, and the power of the time-lens description of pulse manipulation2 where spatial variables are exchanged with time variables and spatial frequencies with temporal frequencies.