gebhart/patrepeval huggingface dataset:
Vascular smooth muscle cell calcium fluxes. Regulation by angiotensin II and lipoproteins. (1993)

This study examined 45Ca uptake, 45Ca efflux, and the distribution of exchangeable 45Ca in confluent, quiescent cultures of aortic smooth muscle cells (VSMCs) from normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). These parameters were investigated under basal conditions and after addition of angiotensin II (Ang II) and low (LDL) and high (HDL) density lipoproteins. Basal 45Ca uptake was approximately 50% greater in VSMCs from SHRs (p < 0.005 versus WKY). Calcium antagonists (diltiazem or nifedipine) abolished this difference. The 45Ca uptake response to Ang II was approximately twofold greater in SHR than in WKY VSMCs (p < 0.05), and Ang II-induced increments of 45Ca uptake were weakly inhibited (by approximately 15-25%) by calcium antagonists. Lipoproteins also stimulated 45Ca uptake in VSMCs, and the apparent affinity of this process was approximately fivefold greater for LDL than for HDL. Calcium antagonists did not inhibit either LDL- or HDL-induced 45Ca uptake. SHR and WKY VSMCs did not differ with respect to 45Ca uptake induced by either LDL or HDL. The initial size of the slowly exchangeable pool of intracellular Ca2+ was approximately 35% greater in SHR VSMCs (p < 0.05 versus WKY). Ang II-induced mobilization of intracellular calcium (measured as the decrease in 45Ca content of the slowly exchangeable pool) was threefold greater in SHR VSMCs (p < 0.005 versus WKY). LDL and HDL marginally stimulated 45Ca efflux from this pool (< or = 20% above control) and to comparable extents in both SHR and WKY VSMCs.(ABSTRACT TRUNCATED AT 250 WORDS)
An adaptive redundant image elimination for Wireless Capsule Endoscopy review based on temporal correlation and color-texture feature similarity (2015)

This paper proposes an approach to eliminate redundant images adaptively for Wireless Capsule Endoscopy (WCE) video summarization by considering temporal correlation and feature similarity between adjacent WCE frames. The color and texture features, generated by HSV color histogram model and Gray Level Co-occurrence Matrix, have been taken into account. It is noted that frames from different WCE videos may have different dynamic information ranges. Hence a data-driven threshold termed as W-parametric mean value threshold (W-MVT) is developed to improve robustness of the proposed method. By comparing the color-texture feature similarity of adjacent WCE frames with W-MVT sequentially, the temporal correlated images with certain similarity are grouped into the same clip. Eventually, to consider gradient varying characteristic in one clip, the adaptive K-means clustering algorithm is adopted to keep key frames while remove redundant frames further. Experimental results show that two evaluation indicators-F-measure and compression ratio achieve 81.94% and 80.31%, which validates the effectiveness of the proposed WCE redundant image elimination (WCE-RIE) method.
Methodology for evaluation of mobility-lifetime product by spectroscopy measurements in CdZnTe spectrometers (1997)

A novel methodology is presented for extraction of the semiconductor electron and hole mobility-lifetime products by x- and γ-ray spectroscopy analysis. The methodology is based on the analysis of spectroscopy results, namely the maximal and the average charge collection efficiencies as discussed below, for different photon energies at various bias voltages. The methodology enables the evaluation of both electron and hole mobility-lifetime products without the need to use α particle measurements. The evaluation is carried out by a single parameter fitting of the models analyzed in this study. Mobility-lifetime products for CdZnTe substrates grown by Bridgman and high pressure Bridgman (HPB) methods are reported and compared. Typical values of μe⋅τe=2⋅10−3 and μh⋅τh=1⋅10−5 cm2/V are extracted for HPB grown CdZnTe with 10% Zn concentration. Values of μe⋅τe=9⋅10−4 and μh⋅τh=1⋅10−7 cm2/V are obtained for CdZnTe with 10% Zn concentration grown by the Bridgman method.
Henry's Law Constant for Selected Volatile Organic Compounds in High-Boiling Oils (1996)

Henry's law constants of four different volatile organic compounds, namely, acetone, methanol, methylene chloride, and toluene between air and high-boiling oils were determined experimentally by the headspace-GC technique over a temperature range. The Henry's law constants were fitted as a function of temperature to an equation.
Aromatherapy For Everyone (1987)

Offering speculations on the psychological effects of essential oils used in aromatherapy, as well as their physical properties, this book gives an account of their history, their use in treatment, therapeutic agents and the state of the art today.
Textbook of Therapeutics: Drug and Disease Management (1996)

General fluid & electrolytes and nutrition diseases of the blood endocrine and metabolic diseases renal diseases gastrointestinal diseases hepatic and pancreatic disorders rheumatic diseases respiratory diseases cardiovascular disorders skin diseases diseases of the eye and ear neurologic disorders psychiatric disorders infectious diseases neoplastic disorders pediatric and neonatal therapy OB-GYN disorders gerontology critical care.
Invasion of extracellular matrix by cultured colon cancer cells: dependence on urokinase receptor display. (1990)

Several urokinase-expressing tumor cells display surface receptors that avidly bind the plasminogen activator. The present study was undertaken to determine the importance of receptor bound urokinase in promoting the invasive phenotype by cultured colon cancer cells. An HCT 116 cell line that elaborates urokinase and displays 11 x 10(4) receptors per cell, 57% of which are tagged with endogenous plasminogen activator, invaded extracellular matrix (Matrigel) in a plasminogen dependent manner. Matrigel invasion was contingent on plasmin production mediated by urokinase, since epsilon-aminocaproic acid diminished the invasive capacity of the HCT 116 cells by 75%. A specific urokinase receptor peptide-antagonist reduced cell invasion in a dose dependent manner with a maximum effect (78% reduction in tumor cell infiltration) being achieved with a 10(-4) M concentration. These results did not reflect a non-specific "shut down" of urokinase expression by the receptor antagonist insofar as steady state urokinase transcript levels were unchanged compared with untreated controls. In addition, LH-RH, a control peptide, failed to suppress Matrigel invasion by HCT 116 cells. The CBS and FET colon cancer cell lines, which secrete amounts of urokinase similar to HCT 116 cells and display one tenth of the receptor number were found to be poorly invasive. Over a three day period, less than 0.8% of these cells invaded the Matrigel in contrast to the 6.9% seen for HCT 116 cells. These data suggest that for cultured colon cancer cells, at least, the display of receptor bound urokinase was a prerequisite for plasminogen dependent invasion.
Introduction of a New Class of Ligands for the Metal‐Catalyzed Enantioselective Synthesis (1993)

Abstract Protected thiosugars were prepared as ligands for the metal‐catalyzed enantioselective synthesis. The protecting groups in these ligands were varied to test a proposed new concept for the metal‐catalyzed enantioselective synthesis. This new concept centres on the use of a stair‐like ligand with a large substituent on one side and a small substitutent on the other rather than the commonly employed ligands which have C 2 symmetry (see Fig.3 ). In such a ligand, both substituents should have a major influence on the coordination of a prochiral substrate. To test this proposal, 3‐thio‐α‐ D ‐glucofuranose derivatives with the following substituents were synthesized: 1,2‐ O ‐isopropylidene‐5,6‐ O ‐methylidene (see 24 ), 1,2:5,6‐di‐ O ‐isopropylidene (see 2 ), 5,6‐ O ‐cyclohexylidene‐1,2‐ O ‐isopropylidene (see 23 ), 1,2‐ O ‐cyclohexylidene‐5,6‐ O ‐isopropylidene (see 14 ), 1,2:5,6‐di‐ O ‐cyclohexylidene (see 13 ), 5,6‐ O ‐(adamantan‐2‐ylidene)‐1,2‐ O ‐isopropylidene (see 21 ), and 1,2:5,6‐di‐ O ‐(adamantan‐2‐ylidene) (see 25 , Table 2 ). As a representative of the allofuranoses, 1,2:5,6‐di‐ O ‐isopropylidene‐3‐thio‐α‐ D ‐allofuranose ( 6 ) was chosen. The following derivatives of 1,2‐ O ‐isopropylidene‐α‐ D ‐xylofuranose were also synthesized: 1,2‐ O ‐isopropylidene‐5‐deoxy‐3‐thio‐α‐ D ‐xylofuranose ( 29 ), 1,2‐ O ‐isopropylidene‐3‐thio‐α‐ D ‐xylofuranose ( 28 ) and 5‐ O ‐[( tert ‐butyl)‐diphenylsilyl]‐1,2‐ O ‐isopropylidene‐3‐thio‐α‐ D ‐xylofuranose ( 15 , see Table 2 ). The proposed concept was tested using the copper‐catalyzed 1,4‐addition of BuMgCl to cyclohex‐2‐en‐1‐one. The enantioselectivity was very dependent on the ligand used and was up to 58%.
Matrix transformer for LLC resonant converters (2013)

In this paper, a high efficiency high power density matrix transformer structure for LLC resonant converters is proposed. Matrix transformer is help to reduce leakage inductance and the AC resistance of windings. Flux cancellation method is utilized to reduce core size and loss. Synchronous Rectifier (SR) devices and output capacitors are integrated into secondary windings to eliminate termination related winding losses, via loss and leakage inductance. An 1.6 MHz 390 /12 V 1kW LLC resonant converter prototype is built to verify the proposed structure.
Passive Scalars in Turbulent Flows (2000)

▪ Abstract Passive scalar behavior is important in turbulent mixing, combustion, and pollution and provides impetus for the study of turbulence itself. The conceptual framework of the subject, strongly influenced by the Kolmogorov cascade phenomenology, is undergoing a drastic reinterpretation as empirical evidence shows that local isotropy, both at the inertial and dissipation scales, is violated. New results of the complex morphology of the scalar field are reviewed, and they are related to the intermittency problem. Recent work on other aspects of passive scalar behavior—its spectrum, probability density function, flux, and variance—is also addressed.
Coding sequence of human<i>rho</i>cDNAs clone 6 and clone 9 (1988)

Journal Article Coding sequence of human rho cDNAs clone 6 and clone 9 Get access P. Chardin, P. Chardin Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Madaule, P. Madaule 1CNRS Laboratoire de Physiologic Nerveuse Dpt 191190 Gif sur Yvette, France Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Tavitian A. Tavitian Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 6, 25 March 1988, Page 2717, https://doi.org/10.1093/nar/16.6.2717 Published: 25 March 1988 Article history Received: 26 February 1988 Published: 25 March 1988
Auditory and visual feedback during eye typing (2003)

We describe a study on how auditory and visual feedback affects eye typing. Results show that the feedback method influences both text entry speed and error rate. In addition, a proper feedback mode facilitates eye typing by reducing the user's need to switch her gaze between the on-screen keyboard and the typed text field.
Genetic Regulations of the Biosynthesis of Microbial Surfactants: An Overview (2008)

Microbial biosurfactants are surface active metabolites synthesized by microbes growing on a variety of substrates. In spite of having great potential for commercial, therapeutic and environmental applications, industrial level production has not been realized for their low yields and productivities. One vital factor determining their biosynthesis is the genetic makeup of the producer organisms. Studies on molecular genetics and biochemistry of the synthesis of several biosurfactants have revealed the operons, the enzymes and the metabolic pathways required for their extracellular production. Surfactin, a cyclic lipopeptide biosurfactant is a potent antimicrobial agent and is produced as a result of non-ribosomal biosynthesis catalyzed by a large multienzyme peptide synthetase complex called the surfactin synthetase. Pathways for the synthesis of other lipopeptides such as iturin, lichenysin and arthrofactin are also mediated by similar enzyme complexes. These non-ribosomal peptide synthetases (NRPSs) responsible for lipopeptide biosynthesis display a high degree of structural similarity among themselves even from distant microbial species. Plasmid-encoded- rhlA, B, R and I genes of rhl quorum sensing system are required for production of glycolipid biosurfactants by Pseudomonas species. Molecular genetics of biosynthesis of alasan and emulsan by Acinetobacter species and of the fungal biosurfactants such as mannosylerythritol lipids (MEL) and hydrophobins have been deciphered. However, limited genetic information is available about biosynthesis of other biosurfactants such as viscosin, amphisin and putisolvin produced by some strains of Pseudomonas species. Understanding of the genetic regulatory mechanisms would help to develop metabolically engineered hyper-producing strains with better product characteristics and acquired capability of utilizing cheap agro-industrial wastes as substrates. This article thus provides an overview of the role and importance of molecular genetics and gene regulation mechanisms behind the biosynthesis of various microbial surfactants of commercial importance.
The Search for Highly Colored Organic Compounds (1989)

Abstract Until now the study of organic compounds in which the π‐electron system is excited by absorbed light has been mainly concentrated on the ultraviolet and visible regions of the electromagnetic spectrum. Various new applications, such as the use of conjugated organic compounds as dye lasers or as materitals for storing information with the help of diode lasers, led to the synthesis of new compounds which absorb light in the near in infrared (NIR). It is possible to use structure‐color relationships to predict the properties of such new compounds when they belong to dyestuff classes which have already been studied in detail; in this case the approach involves decreasing the energy difference between the ground state and the first excited state. A less conventional starting point is provided by molecular structures in which from the outset there is only a very small energy difference between the lowest‐energy electronic states; such diradicaloid molecules occupy a special position among the various types of organic compounds. It is possible by means of suitable structural modification to stabilize such molecules in a singlet from which absorbs light at very long wavelengths (i.e. at small wave numbers).
Carbon Nanotube Electron Emitter for X-ray Imaging (2012)

The carbon nanotube field emitter array was grown on silicon substrate through a resist-assisted patterning (RAP) process. The shape of the carbon nanotube array is elliptical with 2.0 × 0.5 mm2 for an isotropic focal spot size at anode target. The field emission properties with triode electrodes show a gate turn-on field of 3 V/µm at an anode emission current of 0.1 mA. The author demonstrated the X-ray source with triode electrode structure utilizing the carbon nanotube emitter, and the transmitted X-ray image was of high resolution.
Group C Niemann‐Pick disease: faulty regulation of low‐density lipoprotein uptake and cholesterol storage in cultured fibroblasts (1987)

Incubation of mutant Niemann-Pick C fibroblasts with low-density lipoprotein (LDL) resulted in excessive internalization of lipoprotein and extensive cellular over-accumulation of unesterified cholesterol. The uptake of LDL by the mutant cells appeared to occur through the classic LDL receptor pathway and internalized lipoprotein was processed in lysosomes. Lipoprotein uptake into mutant cells was associated with delays in the initiation of established cellular cholesterol homeostatic responses. Subcellular fractionation of mutant Niemann-Pick C fibroblasts accumulating LDL-cholesterol showed excess unesterified sterol to be localized in the light lysosome-light membrane region of a Percoll gradient, and revealed that cholesterol storage was associated with a specific alteration in the normal profiles of lysosomal marker enzymes.
Ultratrace Analyses by Optical Emission Spectroscopy: The Stray Light Problem (1976)

When atomic emission spectroscopy is employed for the determination of trace elements at concentrations near the detection limit, the spectral background will normally be a large fraction of the total measured signal. Precise background corrections are therefore required if accurate analyses are to be achieved. Experimental evidence is presented to document the fact that stray light may produce substantial shifts in the background signal measured with some spectrometers when the total composition of the sample changes. The data presented have been obtained with the inductively coupled plasma as an excitation source; similar effects can be expected with other excitation sources as well. Examples of various forms of stray light originating from grating defects (ghosts, near and far scatter) and defects in the design of spectrometers are presented. Various methods for the reduction, elimination or correction of stray light effects are also discussed.
The vision-based vehicle detection and incident detection system in Hsueh-Shan tunnel (2008)

The automatic lane marking detection, vehicle detection and incident detection systems are proposed in this paper. The block-based background extraction that combines statistical algorithm and the moving block information is used to obtain the color background image more exactly. The lane detection algorithm is applied to obtain the lane information from the color background image without the limitation of the camera setting. The presented vehicle detection algorithm is a block-based approach which is widely used in highway systems, urban roadways or tunnels. Different applications adopt the different detection zones where the vehicles will be tracked and identified in. The presented incident detection algorithm focuses on the car stopped, vehicle lane changing, and congestion condition, and the experimental results in Hsueh-Shan tunnel are addressed, which also demonstrate the stability and the effectiveness of the proposed methods.
A genetic link between<i>Tbx1</i>and fibroblast growth factor signaling (2002)

Tbx1 haploinsufficiency causes aortic arch abnormalities in mice because of early growth and remodeling defects of the fourth pharyngeal arch arteries. The function of Tbx1 in the development of these arteries is probably cell non-autonomous, as the gene is not expressed in structural components of the artery but in the surrounding pharyngeal endoderm. We hypothesized that Tbx1 may trigger signals from the pharyngeal endoderm directed to the underlying mesenchyme. We show that the expression patterns of Fgf8 and Fgf10, which partially overlap with Tbx1 expression pattern, are altered in Tbx1(-/-) mutants. In particular, Fgf8 expression is abolished in the pharyngeal endoderm. To understand the significance of this finding for the pathogenesis of the mutant Tbx1 phenotype, we crossed Tbx1 and Fgf8 mutants. Double heterozygous Tbx1(+/-);Fgf8(+/-) mutants present with a significantly higher penetrance of aortic arch artery defects than do Tbx1(+/-);Fgf8(+/+) mutants, while Tbx1(+/+);Fgf8(+/-) animals are normal. We found that Fgf8 mutation increases the severity of the primary defect caused by Tbx1 haploinsufficiency, i.e. early hypoplasia of the fourth pharyngeal arch arteries, consistent with the time and location of the shared expression domain of the two genes. Hence, Tbx1 and Fgf8 interact genetically in the development of the aortic arch. Our data provide the first evidence of a genetic link between Tbx1 and FGF signaling, and the first example of a modifier of the Tbx1 haploinsufficiency phenotype. We speculate that the FGF8 locus might affect the penetrance of cardiovascular defects in individuals with chromosome 22q11 deletions involving TBX1.
<i>α</i>-Investing: a Procedure for Sequential Control of Expected False Discoveries (2008)

Summary α-investing is an adaptive sequential methodology that encompasses a large family of procedures for testing multiple hypotheses. All control mFDR, which is the ratio of the expected number of false rejections to the expected number of rejections. mFDR is a weaker criterion than the false discovery rate, which is the expected value of the ratio. We compensate for this weakness by showing that α-investing controls mFDR at every rejected hypothesis. α-investing resembles α-spending that is used in sequential trials, but it has a key difference. When a test rejects a null hypothesis, α-investing earns additional probability towards subsequent tests. α-investing hence allows us to incorporate domain knowledge into the testing procedure and to improve the power of the tests. In this way, α-investing enables the statistician to design a testing procedure for a specific problem while guaranteeing control of mFDR.
Her Classroom Is Statewide (2017)

Taking information about and samples of new finishes and developments in fabrics to the people of Iowa is one of the jobs of Miss Opal Roberson, extension clothing specialist of the college.
Craniosynostosis associated with FGFR3 pro250arg mutation results in a range of clinical presentations including unisutural sporadic craniosynostosis. (1997)

Several mutations involving the fibroblast growth factor receptor (FGFR) gene family have been identified in association with phenotypically distinct forms of craniosynostosis. One such point mutation, resulting in the substitution of proline by arginine in a critical region of the linker region between the first and second immunoglobulin-like domains, is associated with highly specific phenotypic consequences in that mutation at this point in FGFR1 results in Pfeiffer syndrome and analogous mutation in FGFR2 results in Apert syndrome. We now show that a much more variable clinical presentation accompanies analogous mutation in the FGFR3 gene. Specifically, mental retardation, apparently unrelated to the management of the craniosynostosis, appears to be a variable clinical consequence of this FGFR3 mutation.
Simultaneous measurements of free thyroxine and triiodothyronine fractions in human serum by means of equilibrium dialysis (1975)

Simultaneous measurements of serum free thyroxine (T4) and triiodothyronine (T3) fractions were studied using a modification of equilibrium dialysis described by Sterling and Brenner. To 1.2 ml of the serum to be assayed, 131I-T4 and 125I-T3 were added in a concentration of 2 mug/dl and 25 ng/dl, respectively, both of which were preliminarily dialysed according to Schussler and Plager. Half ml of the serum with tracers added was dialysed against 9 ml of phosphate buffer (ionic strength 0.15, pH 7.4) for 18 hours at 37 degrees C and 0.1 ml was reserved from the rest in a counting tube (in duplicate). After the completion of dialysis, the dialysate was mixed with 1 ml of pool serum and the contaminating inorganic iodide (in the form of 131I or 125I) was eliminated by adsorption on anion exchange resin. The radioactivity of 3 ml of the dialysate and 0.1 ml of the preserved serum (with the tracers added) was counted and the free (or dialysable) fractions were expressed as a ratio of the count of the former divided by that of the latter adjusted to an equal volume by calculation. The amount of either T4 or T3 added as tracers had no influence on free T4 or T3 fraction unless either of them was added to a concentration of 10 mug/dl. When 125I-T3 of low specific activity (50 muCi/ug) was used as a tracer, free T3 fraction measured simultaneously with free T4 fraction tended to be higher than that measured with a single tracer. When 125I-T3 of higher specific activity (300 muCi/mug) was employed, free T3 fraction obtained with two methods did not differ significantly. Using serum T4 and T3 concentrations measured by competitive protein binding analysis and radioimmunoassay, respectively, the free T4 and T3 concentrations were estimated with sera of normal, hyperthyroid, hypothyroid and uncomplicated pregnant subjects.