gebhart/patrepeval huggingface dataset:
Synthese und physikalische Eigenschaften von 3,6-Di-tert-butyl-1,4-diazapentalen (1988)

Nur induktiv stabilisiert ist das Pentalenderivat 2, das aus dem Dihydroderivat 1 mit Nickelperoxid erhalten wurde. Aus einem Vergleich der spektroskopischen Daten mit den Ergebnissen von MNDO-Rechnungen läßt sich eine Dominanz der gezeichneten Kekulé-Struktur, d. h. eine Bindungsfixierung, ableiten.
A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma (2013)

CP-870,893 in combination with gemcitabine was well-tolerated and associated with antitumor activity in patients with PDA. Changes in FDG uptake detected on PET/CT imaging provide insight into therapeutic benefit. Phase II studies are warranted.
DNA Components for Molecular Architecture (1997)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDNA Components for Molecular ArchitectureNadrian C. SeemanView Author Information Department of Chemistry, New York University, New York, New York 10003 Cite this: Acc. Chem. Res. 1997, 30, 9, 357–363Publication Date (Web):September 11, 1997Publication History Received19 February 1997Published online11 September 1997Published inissue 1 September 1997https://pubs.acs.org/doi/10.1021/ar9601407https://doi.org/10.1021/ar9601407research-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views821Altmetric-Citations118LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catenanes,Genetics,Ligation,Molecules,Nucleic acid structure Get e-Alerts
Synthesis of N3- and 2-NH<sub>2</sub>-substituted 6,7-diphenylpterins and their use as intermediates for the preparation of oligonucleotide conjugates designed to target photooxidative damage on single-stranded DNA representing the bcr–abl chimeric gene (2004)

Two 17-mer oligodeoxynucleotide-5'-linked-(6,7-diphenylpterin) conjugates, 2 and 3, were prepared as photosensitisers for targeting photooxidative damage to a 34-mer DNA oligodeoxynucleotide (ODN) fragment 1 representing the chimeric bcr-abl gene that is implicated in the pathogenesis of chronic myeloid leukaemia (CML). The base sequence in the 17-mer was 3'G G T A G T T A T T C C T T C T T5'. In the first of these ODN conjugates (2) the pterin was attached at its N3 atom, via a -(CH2)3OPO(OH)- linker, to the 5'-OH group of the ODN. Conjugate 2 was prepared from 2-amino-3-(3-hydroxypropyl)-6,7-diphenyl-4(3H)-pteridinone 10, using phosphoramidite methodology. Starting material 10 was prepared from 5-amino-7-methylthiofurazano[3,4-d]pyrimidine 4 via an unusual highly resonance stabilised cation 8, incorporating the rare 2H,6H-pyrimido[6,1-b][1,3]oxazine ring system. In the characterisation of 10 two pteridine phosphazenes, 15 and 29, were obtained, as well as new products containing two uncommon tricyclic ring systems, namely pyrimido[2,1-b]pteridine (20 and 24) and pyrimido[1,2-c]pteridine (27). In the second ODN conjugate the linker was -(CH2)5CONH(CH2)6OPO(OH)- and was attached to the 2-amino group of the pterin. In the preparation of 3, the N-hydroxysuccinimide ester 37 of 2-(5-carboxypentylamino)-6,7-diphenyl-4(3H)-pteridinone was condensed with the hexylamino-modified 17-mer. Excitation of 36 with near UV light in the presence of the single-stranded target 34-mer, 5'T G A C C A T C A A T A A G14 G A A G18 A A G21 C C C T T C A G C G G C C3' 1 caused oxidative damage at guanine bases, leading to alkali-labile sites which were monitored by polyacrylamide gel electrophoresis. Cleavage was observed at all guanine sites with a marked preference for cleavage at G14. In contrast, excitation of ODN-pteridine conjugate 2 in the presence of 1 caused oxidation of the latter predominantly at G18, with a smaller extent of cleavage at G15 and G14 (in the double-stranded portion) and G21. These results contrast with our previous observation of specific cleavage at G21 with ruthenium polypyridyl sensitisers, and suggest that a different mechanism, probably one involving Type 1 photochemical electron transfer, is operative. Much lower yields were found with the ODN-pteridine conjugate 3, perhaps as a consequence of the longer linker between the ODN and the pteridine in this case.
Oral yeast infections in immunocompromised and seriously diseased patients (1990)

The number of immunocompromised patients has increased during recent years. Most fungal infections in these patients are caused by Candida, Aspergillus, Mucor, and Cryptococcus species. Patients with low granulocyte count are at the highest risk of invasive candidal infection. The commonest type of granulocytopenia is observed in connection with malignant diseases of the hematopoietic system. Cytotoxic treatment and radiotherapy of large-body areas tend to produce a significant decrease in circulating granulocytes. Early diagnosis and adequate treatment of fungal infections are mandatory for a successful outcome. In the oral cavity it is important to differentiate between colonization and invasive infection. The optimal approach to diagnosis is a combination of histology and cultivation of specimens obtained from the same site of suspected infection. Prophylaxis of oral fungal infection in immunocompromised patients is generally aimed at preventing colonization.
Real-time lane markings recognition based on seed-fill algorithm (2019)

Road markings express the rules for the road while catching the upcoming road layout. These rules are applied to driving scenarios by real drivers who are known to Highway driving manuals. However, autonomous driving vehicles must read the roads in the same way that real drivers do. In this paper, the problem of automatically reading the road markings is addressed. A new approach for lane classification using the onboard camera is presented. As an initial step, the road boundaries are detected using the Hough transform model. The region of interest (ROI) is divided into two sub-regions. Hough Transform is applied to each of the sub-regions independently. The computational time required for lane detection is improved in this way. After that, adaptive smoothing and some processing steps are added to reduce the noise while still making the close edge's apart. Then, Seed fill algorithm is applied to the lanes location to identify the lane markings types. This method is able to recognize five types of lane markings such as: dashed, solid, double solid, dashed-solid and solid-dashed. The method is applied to a large set of video sequences with various situations and showed that the accuracy is over 95%.
The Power of a Small College (2010)

Gandhi showed the world what a small body of determined spirits could accomplish together. At Linfield, we know something about determination and the power of a small community.
Load Rating Theory for Multi-Channel Amplifiers* (1939)

The amplifiers of multi-channel telephone systems must be so designed with regard to output capacity that interchannel interference caused by amplifier overloading will not be serious. Probability theory is applied to this problem to determine the maximum single frequency output power which a multi-channel amplifier should be designed to transmit as a function of N, the number of channels in the system. The theory is developed to include the effects of statistical variations in the number of simultaneous talkers, in the talking volumes, and in the instantaneous voltages from speech at constant volume.
Powering the Internet - broadband equipment in all facilities - the need for a 300 V DC powering and universal current option (2003)

There are big opportunities to replace the present AC-UPS systems by introducing 300 V single mode parallel operating system in telephone exchange facilities. In doing this, one can expect higher accessibility and extended back-up times. As an extension of this, all 48 V system can eventually be abandoned at a pace when servers and routers will handle a greater part of the telephone traffic. To ease the implementation, a unanimous view regarding the necessity of having a standardised interface is needed, as well as a certification for 300 V DC of today's AC fed equipment.
Who Said That? The Crossmodal Matching Identity for Inferring Unfamiliar Faces from Voices (2012)

This paper proposes a method for matching unfamiliar person's face to unfamiliar voice. The idea behind this is crossmodal perception of human including many illusions such as the McGurk effect, ventriloquist illusion, and so on. Especially, we focus on recent psychological evidence suggesting human can do matching between unfamiliar faces and unfamiliar voices to some extent. The aim of this paper is to mimic this ability on a computer. In order to realize the matching of an unfamiliar person's face to an unfamiliar voice, a dataset of pairs of facial images and corresponding voices are used as knowledge. It means that the unfamiliar voice is matched to the closest known speaker model. Since the database contains corresponding facial image, the system can estimate a closest known face from the unfamiliar voice. Finally each unfamiliar face is matched to the estimated known face and the final recognition result is obtained. To this end, we first implement a speaker recognition system based on Mel Frequency Cepstral Coefficients as the speech feature and Gaussian mixtures models as the classifier. We also use a two-dimensional HMM-based face recognizer and propose a statistical integration of audio/visual recognition results. To show the possibility of the proposed system, unfamiliar speaker recognition experiments are carried out using 60 sentences from the ATR-503 sentences uttered by 20 university students.
Chemistry of Western Pines. (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of Western Pines.Arthur B. AndersonCite this: Ind. Eng. Chem. 1946, 38, 4, 450–454Publication Date (Print):April 1, 1946Publication History Published online1 May 2002Published inissue 1 April 1946https://pubs.acs.org/doi/10.1021/ie50436a026https://doi.org/10.1021/ie50436a026research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Substrate reduction therapy: clinical evaluation in type 1 Gaucher disease (2003)

Glycosphingolipid (GSL) lysosomal storage disorders are inherited enzyme deficiencies that result in pathological lysosomal accumulation of glycolipids, with widespread clinical consequences. Type 1 Gaucher disease is the commonest of these; the deficient enzyme in this condition is glucocerebrosidase. Clinical manifestations include hepatosplenomegaly, thrombocytopenia, anaemia, recurrent infections and skeletal lesions. The condition can be treated with intravenous enzyme replacement therapy (ERT). Substrate reduction therapy is a new approach in which glycolipid accumulation is counteracted not by replacing the deficient enzyme but by reducing the substrate level to better balance residual activity of the deficient enzyme. Miglustat is an inhibitor of glucosylceramide synthase, a key enzyme in GSL synthesis. Oral administration of miglustat to patients with type 1 Gaucher disease attenuates the synthesis of glucocerebroside, the substrate of the deficient glucocerebrosidase. In the first clinical study, patients with type 1 Gaucher disease who had enlargement of the liver or spleen and (if present) the spleen at baseline received 12 months treatment with oral miglustat. There were mean decreases in liver and spleen volumes of 12% (7.9-16.4, p < 0.001) and 19% (14.3-23.7, p < 0.001), respectively. Mean haemoglobin increased by 0.26 g dl(-1) (-0.5-0.57, not statistically significant) and platelet count by 8.3 x 10(9) l(-1) (1.9-14.7, p = 0.014).
“Slim” Nucleosides and Nucleotides. I. Synthetic, Structural and Biophysical Investigations of Showdomycins (1994)

A new, convenient, and short synthesis of 2'-deoxyshowdomycin, along with an improved procedure for the preparation of showdomycin, have been presented. A single-crystal X-ray structure of 1-benzyl-2'-deoxyshowdomycin (9) has been reported. Conformational studies using C.D. indicated that showdomycin exists predominantly in an anti conformation in aqueous solution. Molecular mechanics calculations using AMBER point to comparable binding energy of showdomycin-adenosine pair with the natural uridine-adenosine pair, but with a significant base-ribose conformational deviation from the natural array in the former. Implications of such a conformational deviation on tumor and viral replications have been discussed. Base-pairing studies employing high resolution NMR spectroscopy indicate that both showdomycin and epishowdomycin base-pair with adenosine-5'-monophosphate (AMP); however, while showdomycin also shows evidence of stacking, that was absent in epishowdomycin. Molecular modeling studies using QUANTA/CHARMm show that showdomycin is capable of forming a homopolymer duplex by base-pairing with poly(A), but with a considerably broader and deeper major groove. A heteropolymer duplex with a single insert of showdomycin exhibits tighter coiling at the point of insertion. A ten-picosecond dynamics simulation of the above heteroduplex revealed relaxation of the helix with disruption of H-bonding for two base pairs on either side of the insertion point, forming a large central cavity.
Tn-MUC1 DC Vaccination of Rhesus Macaques and a Phase I/II Trial in Patients with Nonmetastatic Castrate-Resistant Prostate Cancer (2016)

MUC1 is a glycoprotein expressed on the apical surface of ductal epithelial cells. Malignant transformation results in loss of polarization and overexpression of hypoglycosylated MUC1 carrying truncated carbohydrates known as T or Tn tumor antigens. Tumor MUC1 bearing Tn carbohydrates (Tn-MUC1) represent a potential target for immunotherapy. We evaluated the Tn-MUC1 glycopeptide in a human phase I/II clinical trial for safety that followed a preclinical study of different glycosylation forms of MUC1 in rhesus macaques, whose MUC1 is highly homologous to human MUC1. Either unglycosylated rhesus macaque MUC1 peptide (rmMUC1) or Tn-rmMUC1 glycopeptide was mixed with an adjuvant or loaded on autologous dendritic cells (DC), and responses were compared. Unglycosylated rmMUC1 peptide induced negligible humoral or cellular responses compared with the Tn-rmMUC1 glycopeptide. Tn-rmMUC1 loaded on DCs induced the highest anti-rmMUC1 T-cell responses and no clinical toxicity. In the phase I/II clinical study, 17 patients with nonmetastatic castrate-resistant prostate cancer (nmCRPC) were tested with a Tn-MUC1 glycopeptide-DC vaccine. Patients were treated with multiple intradermal and intranodal doses of autologous DCs, which were loaded with the Tn-MUC1 glycopeptide (and KLH as a positive control for immune reactivity). PSA doubling time (PSADT) improved significantly in 11 of 16 evaluable patients (P = 0.037). Immune response analyses detected significant Tn-MUC1-specific CD4<sup>+</sup> and/or CD8<sup>+</sup> T-cell intracellular cytokine responses in 5 out of 7 patients evaluated. In conclusion, vaccination with Tn-MUC1-loaded DCs in nmCRPC patients appears to be safe, able to induce significant T-cell responses, and have biological activity as measured by the increase in PSADT following vaccination. Cancer Immunol Res; 4(10); 881-92. ©2016 AACR.
Conversion of polyolefin wax to carbon adsorbents by thermooxidation treatment (2014)

Carbon adsorbents with different properties were obtained from furfural and mixture of furfural and polymer waste (polyolefine wax) with different activation reagents and different conditions of treatment. The carbons obtained have insignificant ash content. It was determined, that pore volume, pore size distribution and the chemical character of the surface of the carbon adsorbents depend on the selected activation reagents and temperature of treatment. The IR spectra and Boehm method show that various oxygen-containing groups with acidic (carboxylic, carboxylic in lactonelike bonding, phenolic, hydroxyl and carbonyl groups) and basic character are present on the carbon surface. Our investigations reveal that on the base of polymer waste, different activated carbons were obtained, and they could be used as effective adsorbents for removal of toxic metal and organic pollutants.
Dual actions of fibroblast growth factor 19 on lipid metabolism (2012)

Elevated triglyceride (TG) and cholesterol levels are risk factors for cardiovascular disease and are often associated with diabetes and metabolic syndrome. Recent reports suggest that fibroblast growth factor (FGF)19 and FGF21 can dramatically improve metabolic dysfunction, including hyperglycemia, hypertriglyceridemia, and hypercholesterolemia. Due to their similar receptor specificities and co-receptor requirements, FGF19 and FGF21 share many common properties and have been thought to be interchangeable in metabolic regulation. Here we directly compared how pharmacological administration of recombinant FGF19 or FGF21 proteins affect metabolism in B6.V-Lep(ob)/J leptin-deficient mice. FGF19 and FGF21 equally improved glucose parameters; however, we observed increased serum TG and cholesterol levels after treatment with FGF19 but not with FGF21. Increases in serum TGs were also observed after a 4-day treatment with FGF19 in C57BL6/J mice on a high-fat diet. This is in contrast to many literature reports that showed significant improvements in hyperlipidemia after chronic treatment with FGF19 or FGF21 in high-fat diet models. We propose that FGF19 has lipid-raising and lipid-lowering actions mediated through different FGF receptors and target tissues, and the results described here provide a potential mechanism that may explain the inconsistency in the reported effects of FGF19 on lipid metabolism.
Lightweight authentication and key management on 802.11 with Elliptic Curve Cryptography (2013)

Wireless Local Area Networks (WLANs) have experienced a significant growth during the last decade due to ever emerging and heavy resource demanding applications. Widely used IEEE 802.11 may unexpectedly require long durations in association compared to what Voice over IP (VoIP), Video on Demand (VoD) and other real-time applications can tolerate. In this paper, we implement HIP-WPA; a novel approach of Fast Initial Authentication (FIA) which is a combination of Host Identity Protocol Diet EXchange (HIP-DEX) with some features of Wi-Fi Protected Access (WPA) technology. This approach provides the necessary IP layer elevated security mechanisms in order to face the challenges of fast authentication in WLANs. HIP-DEX introduces a radically new way of authenticating hosts by using Elliptic Curve Cryptography (ECC) only with two message exchanges and therefore improves the authentication delay by 300% compared to WPA2. Thus, this is an effective solution to be used with any type of real-time application for intra-network (Basic Service Set (BSS) transitions) and internetwork (Extended Service Set (ESS) transitions) handovers.
Intraneuronal IgG in the central nervous system (1987)

The uptake of immunoglobins by CNS neurons was studied in rats. Rats were injected IP with solutions containing large amounts of rabbit IgG. Immunocytochemical staining of sections of the neuraxis revealed uptake of rabbit IgG by motor neurons of the CNS with axons projecting outside of the blood-brain barrier, including ventral horn motor neurons and cranial nerve motor nuclei neurons as well as in neurons projecting to the hypothalamus and area postrema. Staining was also noted in certain large neurons of the reticular formation and in Purkinje cells, as well as diffusely in the hypothalamus, area postrema, the pia mater, and associated vasculature and larger penetrating vessels. Uptake of rabbit IgG by lumbar spinal cord motor neurons projecting to the sciatic nerve was prevented by ligation of the sciatic nerve. These experiments support the hypothesis that certain central neurons take up immunoglobins from the periphery by retrograde axonal transport. The function of this process is not known, but it may have significance for the pathogenesis of motor and autonomic neuropathies and neuronopathies.
Review on Histogram Equalization based Image Enhancement Techniques (2016)

The multimedia devices, mobile phones and other palmtop devices are integral part of our day to day life. Image and video processing plays a key role in modern day information and communication technologies. Images captured from cameras needs enhancement for before using them in various applications. Noise removal, contrast improvement, and adjustment of brightness are common operations performed on raw images after capturing from camera. Researchers have proposed variety of image enhancement techniques by using numerical methods, statistics, signal processing. In this paper, Histogram Equalization (HE) method is studied. HE is an important image enhancement scheme and many variations of HE has been proposed. We study most important and highly cited HE techniques in this work and discuss their advantages, limitations and applications.
Direct projective time‐of‐flight NMR angiography within 4 s (1991)

To enhance contrast between flow and static tissue, NMR projective angiographic methods usually require data subtraction, or alternatively the application of special data processing routines such as the "maximum intensity projection" algorithm. We have successfully developed a direct projection method which yields sufficient flow/static contrast in a single acquisition, producing angiograms in under 4 s. Direct projection angiograms of the cervical and abdominal vessels were obtained. The cervical vessels were uniformly depicted in a number of different projection views. The abdominal vessels exhibit intensity variations due to the pulsatile flow pattern. A series of abdominal angiograms were acquired, each triggered at a different starting cardiac phase. When displayed as a movie sequence the pulsatile flow pattern was seen to advance along the arteries. To more uniformly represent the abdominal vessels a 24-s average was adequate. This new technique should allow NMR angiograms to be obtained in a "fluoroscopic" mode.