gebhart/patrepeval huggingface dataset:
Effect of dicarboxylic (C6 and C9) acids on a human squamous carcinoma cell line in culture. (1989)

In tissue culture, azelaic acid (C9) has been shown to have an anti-proliferative and cytotoxic effect on human and murine malignant melanocytes, with inhibition of mitochondrial oxido-reductase enzymes and DNA synthesis, and damage to mitochondria. Recent reports of effects on differentiation of normal keratocytes have led to the present study of its effects on a squamous carcinoma cell line. Cells were exposed to single doses of disodium salts of azelaic (C9(2)Na) and adipic (C6(2)Na) acids at concentrations of 10(-2)M and 5 x 10(-2)M for 48 hrs. Only C9(2)Na at 5 x 10(-2) M for 4 hrs., and longer, significantly affected proliferation, and the cells exhibited massive swelling of mitochondria with loss of cristae. The results further confirm the probable value of azelaic acid as a general anti-tumoral agent rather than a specifically melanocytotoxic one. They could justify clinical studies on the effect of topical azelaic acid therapy on squamous cell carcinoma in vivo.
Positional asphyxiation in adults. A series of 30 cases from the Dade and Broward County Florida Medical Examiner Offices from 1982 to 1990. (1992)

Over a 9-year period, 30 cases of positional (or postural) asphyxia were identified in the Dade and Broward County (Florida) Medical Examiner Offices. The victims had an average age of 50.6 years with no significant sex or racial differences as compared with the general medical examiner population. Chronic alcoholism or acute alcohol intoxication was a significant risk factor in 75% of cases and these had an average postmortem ethanol concentration of 0.24 g%. Signs of mechanical asphyxiation (petechiae and/or combined lung weights greater than 900 g) were present in 93% of cases. Victims were commonly (43%) found in a restrictive position producing hyperflexion of the head and neck. Two deaths involved restraint vests ("poseys") in elderly, demented, wheel-chair-confined victims. Scene photographs of the undisturbed decedent are extremely helpful in confirming a suspicion of postional asphyxia.
Optimized Nomogram Development for LASIK and PRK (2000)

Commercially available software programs can create nomograms for use in surgical planning for refractive surgery procedures that make optimal use of available data. These nomograms have been termed “Optimized Nomograms.” In the development of optimized nomograms, data sets are grouped according to treatment profiles consisting of the specific laser, surgeon, laser software version, Hertz rate, treatment zone diameter, keratome, plate thickness, and user-defined parameters. Regression analyses are performed according to models derived by using actual data sets, and may incorporate linear, nonlinear, logarithmic, scalar, and higher order analyses. Regression results are screened using relevant statistics and only those variables found to have a significant effect on outcomes are used. The data used in the regressions are filtered for outliers, and are limited by using a trailing window analysis with a 0.1 diopter (D) threshold. The variables used in specific nomograms vary among data sets, showing the need for personalization of nomograms for each surgeons and each treatment profile. Optimized nomograms have been shown to result in significant improvement in the correlation of outcomes with the planned results. Optimized nomograms can significantly improve surgical outcomes. Their use depends on consistency in technique and equipment
Primary structures and expression from cDNAs of rat opioid receptor δ‐and μ‐subtypes (1993)

The complete amino acid sequences of rat opioid receptors (designated as ROR-A and ROR-B) have been deduced by cloning and sequencing the cDNAs. The ligand-binding properties of ROR-A and ROR-B expressed from the cloned cDNAs in Chinese hamster ovary cells correspond most closely to those of the pharmacologically defined delta- and mu-opioid receptor subtypes, respectively. RNA blot hybridization analysis revealed that cerebrum and brainstem contain both ROR-A and ROR-B mRNAs, whereas neither ROR-A nor ROR-B mRNAs can be detected in cerebellum.
A reconnaissance study of herbicides and their metabolites in surface water of the midwestern United States using immunoassay and gas chromatography/mass spectrometry (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA reconnaissance study of herbicides and their metabolites in surface water of the midwestern United States using immunoassay and gas chromatography/mass spectrometryE. Michael Thurman, Donald A. Goolsby, Michael T. Meyer, Margaret S. Mills, Michael L. Pomes, and Dana W. KolpinCite this: Environ. Sci. Technol. 1992, 26, 12, 2440–2447Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://doi.org/10.1021/es00036a016RIGHTS & PERMISSIONSArticle Views735Altmetric-Citations294LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Direct-coupled cascaded multilevel sag compensator (2002)

Voltage sags (or dips) are the most common power quality problem. The aim of this paper is to propose a multilevel-cascaded converter, connected in series with the supply, which acts as a sag compensator. The converter is direct-coupled and eliminates the use of costly output filters and injection transformers. The converter operation and control techniques are discussed and confirmed with simulations and practical results.
Design and Implementation of a Polar Codes Blind Detection Scheme (2018)

In blind detection, a set of candidates has to be decoded within a strict time constraint, to identify which transmissions are directed at the user equipment. Blind detection is required by the 3GPP LTE/LTE-A and fifth generation (5G) standards. With the selection of polar codes in 5G, the issue of blind detection of polar codes needs to be addressed. A polar code blind detection scheme has been recently proposed where the user ID is transmitted instead of some of the frozen bits. We propose an architecture to implement an improved version of such scheme. A first, coarse decoding phase helps selecting a subset of candidates that is decoded by a more powerful algorithm: an early stopping criterion is also introduced for the second decoding phase. The architecture relies on a tunable decoder that can be used for both phases. The architecture is synthesized and implementation results are reported for various system parameters. The reported area occupation and latency, obtained in 65-nm CMOS technology, are able to meet 5G requirements.
High efficiency, single-stage, 7 kHz, high average power ultrafast laser system (2001)

Summary form only given. We demonstrate a single-stage, ultrafast, Ti:sapphire laser amplifier system that operates at a repetition frequency from 1 to 10 kHz, with millijoule pulse energy, and up to 8 W average power. The repetition rate can be adjusted continuously from 1-10 kHz, using new all-solid-state. pump laser technology. This represents, to our knowledge, the highest average power ever obtained from a single-stage ultrafast laser amplifier system. This laser will significantly increase the average power and repetition rate easily accessible for high-field experiments such as coherent x-ray generation, or for laser-synchrotron studies.
KIR3DL1/S1 and HLA-B Alleles Combine to Influence Unrelated Hematopoietic Stem Cell Transplantation (HSCT) Outcomes (2012)

NK cells play an important role in immunity against viruses and malignancy. Alleles for KIR3DL1/S1 are associated with improved outcome in HIV infection. Previous studies have shown differential impact of associations between 3DL1 alleles (3DL1-high, -low, -null) and Bw4 alleles (I80, T 80), where higher affinity combinations appear to secure stronger NK response in viral control. Because NK cells play an important role in HSCT we hypothesized that 3DL1 alleles and their hierarchically binding Bw4 ligands would have differential outcomes in HSCT. We performed donor 3DL1/S1 allele typing for 426 patients with myeloid malignancies (AML 70.2%, CML 6.3%, MDS 23.5%) who received URD HSCT. 349 patients received 10/10 HLA matched HSCT, 77 received 9/10 or 8/10 HLA-matched. All patients received an ablative conditioning regimen and 364 patients received T-replete allografts. Overall Bw4-I80 donors were associated with higher relapse compared to Bw6 homozygous and Bw4-T80 donors (HR 1.48; P = .05). Not surprisingly, this association was stronger in Bw4-I80 and 3DL1-positive donors (HR 1.59; P = .03). While there were no overall differences in outcomes among recipients of donors with 3DL1-null (27.96%), 3DL1-high (41.70%) or 3DL1-low (25.83%) allotypes, the combination of 3DL1-high and Bw4-I80 donors, compared with 3DL1-high and Bw6 homozygous or Bw4-T80 donors, were strongly associated with relapse (HR 2.71; P = .001). When the analysis was restricted to AML patients alone (n = 299), 3DL1-high and Bw4-I80 donors remained associated with higher relapse (HR 2.10; P = .04). There was no association between 3DL1-high/Bw4 compound genotypes and NRM or aGVHD, nor between 3DL1-null and 3DL1-low and Bw4 with any outcome. In contrast, we confirmed in this cohort our previous findings that 3DS1-positive donors (36%) were associated with less OM (HR 0.78; P = .04) and NRM (HR 0.70; P = .02). For the first time in HSCT, this study demonstrates the impact of 3DL1 allotypes in HSCT, where combinations of 3DL1-high and their high affinity Bw4 alleles in the donor are associated with higher relapse and OM in patients. Conversely, donor 3DS1 is associated with less OM and NRM. These data offer insights to differential controls of NK biology in HSCT and support not only KIR genotyping but KIR allotyping in order to select donors with the best KIR-HLA combinations to maximize leukemic control while minimizing unwanted toxicities.
Streptopyridines, volatile pyridine alkaloids produced by <i>Streptomyces</i> sp. FORM5 (2014)

Streptomyces sp. FORM5 is a bacterium that is known to produce the antibiotic streptazolin and related compounds. We investigated the strain for the production of volatiles using the CLSA (closed-loop stripping analysis) method. Liquid and agar plate cultures revealed the formation of new 2-alkylpyridines (streptopyridines), structurally closely related to the already known 2-pentadienylpiperidines. The structures of the streptopyridines A to E were confirmed by total synthesis. The analysis of the liquid phase by solvent extraction or extraction with an Oasis adsorbent showed that streptazolin and 2-pentadienylpiperidine are the major compounds, while the streptopyridines are only minor components. In the gas phase, only the streptopyridines could be detected. Therefore, an orthogonal set of analysis is needed to assess the metabolic profile of bacteria, because volatile compounds are obviously overlooked by traditional analytical methods. The streptopyridines are strain specific volatiles that are accompanied by a broad range of headspace constituents that occur in many actinomycetes. Volatiles might be of ecological importance for the producing organism, and, as biosynthetic intermediates or shunt products, they can be useful as indicators of antibiotic production in a bacterium.
Modulation of select immune responses by dietary capsaicin. (1998)

Capsaicin (CAP) is the spicy principle of hot peppers that has been used as a food additive, preservative, and medicine. In this study, we investigated the effect of dietary CAP on immune status and selected immune responses. BALB/c mice were divided into 5 groups and fed diets with either 0, 5, 20, 50 or 100 ppm CAP for 3 weeks. The parameters measured with lymphocytes included mitogen-induced proliferation, plaque-forming cell number, and total serum immunoglobulin levels. In spleen cells of mice fed 20 ppm CAP there was a greater T-cell mitogen induced, lymphocyte proliferative response. In addition, the number of antibody-producing B cells and serum IgG and IgM levels increased in mice fed 20 ppm CAP as compared to the control with no CAP. The effect of dietary CAP on macrophage activity was assessed by phagocytosis and tumor necrosis factor-alpha (TNF alpha) production. Dietary CAP had no effect on phagocytic activity by peritoneal macrophages, but the levels of secreted TNF alpha increased in the groups fed 20 ppm CAP compared to the control. These results suggest that dietary CAP may differentially enhance immune status as well as select immune functions. That is in contrast with previous studies that show immunosuppression observed after CAP injection.
Los niños con dificultades para aprender, la familia y la inteligencia (2015)

Durante los ultimos cinco anos en la provincia Guantanamo se ha realizado una investigacion pedagogica acerca de la educacion familiar de los ninos que presentan significativas dificultades en el aprendizaje a los cuales se les diagnostica por los especialistas como alumnos con retardo en el desarrollo psiquico. Este estudio ha permitido un mejor conocimiento de las caracteristicas de estas familias y del proceso educativo del alumno en ese contexto. En cualquier escuela del mundo del nivel primario hay una minoria de alumnos que constituyen un fuerte problema cientifico pedagogico para sus maestros, los familiares y los funcionarios y especialistas que laboran en esta rama ya que estos llegan a la edad escolar con algunas limitaciones en su desarrollo cognoscitivo y mental en general, lo que les dificulta su aprendizaje escolar y la vida afectivo-volitiva.
Analytical chiral separation methods (IUPAC Recommendations 1997) (1997)

Abstract
First-Episode Schizophrenic Psychosis Differs From First-Episode Affective Psychosis and Controls in P300 Amplitude Over Left Temporal Lobe (1998)

Left-sided P300 abnormality in first-episode schizophrenia relative to first-episode affective psychosis and controls suggests that P300 asymmetry is specific to schizophrenic psychosis and present at initial hospitalization. This P300 asymmetry suggests left temporal lobe dysfunction at the onset of schizophrenia.
Ion channels in spinal cord astrocytes in vitro. I. Transient expression of high levels of Na+ and K+ channels (1992)

1. Na+ and K+ channel expression was studied in cultured astrocytes derived from P--0 rat spinal cord using whole cell patch-clamp recording techniques. Two subtypes of astrocytes, pancake and stellate, were differentiated morphologically. Both astrocyte types showed Na+ channels and up to three forms of K+ channels at certain stages of in vitro development. 2. Both astrocyte types showed pronounced K+ currents immediately after plating. Stellate but not pancake astrocytes additionally showed tetrodotoxin (TTX)-sensitive inward Na+ currents, which displayed properties similar to neuronal Na+ currents. 3. Within 4-5 days in vitro (DIV), pancake astrocytes lost K(+)-current expression almost completely, but acquired Na+ currents in high densities (estimated channel density approximately 2-8 channels/microns2). Na+ channel expression in these astrocytes is approximately 10- to 100-fold higher than previously reported for glial cells. Concomitant with the loss of K+ channels, pancake astrocytes showed significantly depolarized membrane potentials (-28.1 +/- 15.4 mV, mean +/- SD), compared with stellate astrocytes (-62.5 +/- 11.9 mV, mean +/- SD). 4. Pancake astrocytes were capable of generating action-potential (AP)-like responses under current clamp, when clamp potential was more negative than resting potential. Both depolarizing and hyperpolarizing current injections elicited overshooting responses, provided that cells were current clamped to membrane potentials more negative than -70 mV. Anode-break spikes were evoked by large hyperpolarizations (less than -150 mV). AP-like responses in these hyperpolarized astrocytes showed a time course similar to neuronal APs under conditions of low K+ conductance. 5. In stellate astrocytes, AP-like responses were not observed, because the K+ conductance always exceeded Na+ conductance by at least a factor of 3. Thus stellate spinal cord astrocyte membranes are stabilized close to EK as previously reported for hippocampal astrocytes. 6. It is concluded that spinal cord pancake astrocytes are capable of synthesizing Na+ channels at densities that can, under some conditions, support electrogenesis. In vivo, however, AP-like responses are unlikely to occur because the cells' resting potential is too depolarized to allow current activation. Thus the absence of electrogenesis in astrocytes may be explained by two mechanisms: 1) a low Na-to-K conductance ratio, as in stellate spinal cord astrocytes and in other previously studied astrocyte preparations; or, 2) as described in detail in the companion paper, a mismatch between the h infinity curve and resting potential, which results in Na+ current inactivation in spinal cord pancake astrocytes.
Sampling with polyominoes (2007)

We present a new general-purpose method for fast hierarchical importance sampling with blue-noise properties. Our approach is based on self-similar tiling of the plane or the surface of a sphere with rectifiable polyominoes. Sampling points are associated with polyominoes, one point per polyomino. Each polyomino is recursively subdivided until the desired local density of samples is reached. A numerical code generated during the subdivision process is used for thresholding to accept or reject the sample. The exact position of the sampling point within the polyomino is determined according to a structural index, which indicates the polyomino's local neighborhood. The variety of structural indices and associated sampling point positions are computed during the offline optimization process, and tabulated. Consequently, the sampling itself is extremely fast. The method allows both deterministic and pseudo-non-deterministic sampling. It can be successfully applied in a large variety of graphical applications, where fast sampling with good spectral and visual properties is required. The prime application is rendering.
Studies on the ecology of River Beas with reference to benthic fauna (2008)

The paper incorporates the findings on the seasonal abundance and fluctuations of benthic fauna in relation to physico-chemical parameters of water in the selective stretches of river Beas. Considerable variations of benthic fauna in quality and quantity were observed. The population of benthic fauna was high in the month of July (418.0 units/m) while minimum in December (38.0 units/m).
The Anal Pap Smear: Cytomorphology of squamous intraepithelial lesions. (2005)

BACKGROUND: Anal smears are increasingly being used as a screening test for anal squamous intraepithelial lesions (ASILs). This study was undertaken to assess the usefulness and limitations of anal smears in screening for ASILs. METHODS: The cytomorphological features of 200 consecutive anal smears collected in liquid medium from 198 patients were studied and findings were correlated with results of surgical biopsies and/or repeat smears that became available for 71 patients within six months. RESULTS: Adequate cellularity was defined as an average of 6 or more nucleated squamous cells/hpf. A glandular/transitional component was not required for adequacy. Dysplastic cells, atypical parakeratotic cells and bi/multinucleated cells were frequent findings in ASIL while koilocytes were infrequent. Smears from LSIL cases most frequently showed mildly dysplastic and bi/multinucleate squamous cells followed by parakeratotic cells (PK), atypical parakeratotic cells (APK), and koilocytes. HSIL smears contained squamous cells with features of moderate/severe dysplasia and many APKs. Features of LSIL were also found in most HSIL smears. CONCLUSIONS: In this study liquid based anal smears had a high sensitivity (98%) for detection of ASIL but a low specificity (50%) for predicting the severity of the abnormality in subsequent biopsy. Patients with cytologic diagnoses of ASC-US and LSIL had a significant risk (46-56%) of HSIL at biopsy. We suggest that all patients with a diagnosis of ASC-US and above be recommended for high resolution anoscopy with biopsy.
Efficient software implementation of embedded communication protocol controllers using asynchronous software thread integration with time- and space-efficient procedure calls (2007)

The overhead of context switching limits efficient scheduling of multiple concurrent threads on a uniprocessor when real-time requirements exist. A software-implemented protocol controller may be crippled by this problem. The available idle time may be too short to recover through context switching, so only the primary thread can execute during message activity, slowing the secondary threads and potentially missing deadlines. Asynchronous software thread integration (ASTI) uses coroutine calls and integration, letting threads make independent progress efficiently, and reducing the needed context switches. We demonstrate the methods with a software implementation of an automotive communication protocol (J1850) and several secondary threads.
<title>Segmentation-based coding of stereoscopic image sequences</title> (1996)

A binocular disparity based segmentation scheme to compactly represent one image of a stereoscopic image pair given the other image was proposed earlier by us. That scheme adapted the excess bitcount, needed to code the additional image, to the binocular disparity detail present in the image pair. This paper addresses the issue of extending such a segmentation in the temporal dimension to achieve efficient stereoscopic sequence compression. The easiest conceivable temporal extension would be to code one of the sequences using an MPEG-type scheme while the frames of the other stream are coded based on the segmentation. However such independent compression of one of the streams fails to take advantage of the segmentation or the additional disparity information available. To achieve better compression by exploiting this additional information, we propose the following scheme. Each frame in one of the streams is segmented based on disparity. An MPEG-type frame structure is used for motion compensated prediction of the segments in this segmented stream. The corresponding segments in the other stream are encoded by reversing the disparity-map obtained during the segmentation. Areas without correspondence in this stream, arising from binocular occlusions and disparity estimation errors, are filled in using a disparity-map based predictive error concealment method. Over a test set of several different stereoscopic image sequences, high perceived stereoscopic image qualities were achieved at an excess bandwidth that is roughly 40% above that of a highly compressed monoscopic sequence. Stereo perception can be achieved at significantly smaller excess bandwidths, albeit with a perceivable loss in the image quality.