gebhart/patrepeval huggingface dataset:
The proteolytic environment of chronic wounds (1999)

A consistent feature of chronic leg and pressure ulcers is chronic inflammation associated with an elevated infiltration of neutrophils. Neutrophils and their proteases have been implicated in mediating the tissue damage associated with a variety of chronic inflammatory diseases. This review discusses our current understanding of the proteolytic enzymes found in chronic wounds and attempts to relate this information to the abundant presence of neutrophils. In addition, the implications that the proteolytic environment may have for current and future treatment strategies of chronic nonhealing wounds are discussed.
Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2 (2007)

VRX0466617 is a novel selective small-molecule inhibitor for Chk2 discovered through a protein kinase screening program. In this study, we provide a detailed biochemical and cellular characterization of VRX0466617. We show that VRX0466617 blocks the enzymatic activity of recombinant Chk2, as well as the ionizing radiation (IR)-induced activation of Chk2 from cells pretreated with the compound, at doses between 5 and 10 micromol/L. These doses of VRX0466617 inhibited, to some extent, the phosphorylation of Chk2 Ser(19) and Ser(33-35), but not of Chk2 Thr(68), which is phosphorylated by the upstream ataxia-telangiectasia mutated (ATM) kinase. Interestingly, VRX0466617 induced the phosphorylation of Chk2 Thr(68) even in the absence of DNA damage, arising from the block of its enzymatic activity. VRX0466617 prevented the IR-induced Chk2-dependent degradation of Hdmx, concordant with the in vivo inhibition of Chk2. Analysis of ATM/ATM and Rad3-related substrates Smc1, p53, and Chk1 excluded a cross-inhibition of these kinases. VRX0466617 did not modify the cell cycle phase distribution, although it caused an increase in multinucleated cells. Whereas VRX0466617 attenuated IR-induced apoptosis, in short-term assays it did not affect the cytotoxicity by the anticancer drugs doxorubicin, Taxol, and cisplatin. These results underscore the specificity of VRX0466617 for Chk2, both in vitro and in vivo, and support the use of this compound as a biological probe to study the Chk2-dependent pathways.
Improved Safety of Hematopoietic Transplantation with Monkey Embryonic Stem Cells in the Allogeneic Setting (2006)

Cynomolgus monkey embryonic stem cell (cyESC)-derived in vivo hematopoiesis was examined in an allogeneic transplantation model. cyESCs were induced to differentiate into the putative hematopoietic precursors in vitro, and the cells were transplanted into the fetal cynomolgus liver at approximately the end of the first trimester (n = 3). Although cyESC-derived hematopoietic colony-forming cells were detected in the newborns (4.1%-4.7%), a teratoma developed in all newborns. The risk of tumor formation was high in this allogeneic transplantation model, given that tumors were hardly observed in immunodeficient mice or fetal sheep that had been xeno-transplanted with the same cyESC derivatives. It turned out that the cyESC-derived donor cells included a residual undifferentiated fraction positive for stage-specific embryonic antigen (SSEA)-4 (38.2% +/- 10.3%) despite the rigorous differentiation culture. When an SSEA-4-negative fraction was transplanted (n = 6), the teratoma was no longer observed, whereas the cyESC-derived hematopoietic engraftment was unperturbed (2.3%-5.0%). SSEA-4 is therefore a clinically relevant pluripotency marker of primate embryonic stem cells (ESCs). Purging pluripotent cells with this surface marker would be a promising method of producing clinical progenitor cell preparations using human ESCs.
Fatal musculoskeletal injuries incurred during racing and training in Thoroughbreds (1996)

Age and sex-related differences in risk of incurring a FMI during racing should be considered when comparing fatal injury rates among race-meets.
Expression of doxorubicin-daunorubicin resistance genes in different anthracycline-producing mutants of Streptomyces peucetius (1992)

Two DNA fragments, ric1 and ric2, were isolated from the Streptomyces peucetius 7600 mutant, which produces daunorubicin and doxorubicin, on the basis of their abilities to confer doxorubicin and daunorubicin resistance to Streptomyces lividans. These two fragments are unrelated by restriction mapping and do not show any homology by Southern analysis, yet both of them increase the level of resistance 10-fold in transformed S. lividans. Functional analysis revealed that ric1 also contains two genes of daunorubicin biosynthesis: one coding for the aklavinone C-11 hydroxylase and the other corresponding to the putative dnrR2 regulatory gene of wild-type S. peucetius ATCC 29050 (K. J. Stutzman-Engwall, S. L. Otten, and C. R. Hutchinson, J. Bacteriol. 174:144-154, 1992). Northern (RNA) blot experiments, performed with a ric1 fragment containing daunorubicin-doxorubicin resistance gene(s), revealed a transcript of about 2,100 nucleotides that is present only during the phase of anthracycline metabolite production. The amount of this transcript is higher in strain 7600 than in strain 7900, a mutant which produces 5-fold more daunorubicin and 10-fold less doxorubicin than 7600. Furthermore, two 7900-derived blocked mutants, 8600 and 9700, do not express the 2,100-nucleotide transcript in spite of the absence of gross rearrangements in the ric1 region such as occur with the 7900 parental strain.
Sponge‐Templated Preparation of High Surface Area Graphene with Ultrahigh Capacitive Deionization Performance (2014)

Capacitive deionization (CDI) is a competent water desalination technique offering an appropriate route to obtain clean water. However, a rational designed structure of the electrode materials is essentially required for achieving high CDI performance. Here, a novel sponge‐templated strategy is developed for the first time to prepare graphene sheets with high specific surface area and suitable pore size distribution. Sponge is used as the support of graphene oxide to prevent the restack of graphene sheets, as well as to suppress the agglomerate during the annealing process. Importantly, the as‐fabricated graphene sheets possess high specific surface area of 305 m 2 g −1 and wide pore size distribution. Ultrahigh CDI performance, a remarkable electrosorptive capacity of 4.95 mg g −1 , and siginificant desorption rate of 25 min, is achieved with the sponge‐templated prepared graphene electrodes. This work provides an effective solution for the synthesis of rational graphene architectures for general applications in CDI, energy storage and conversion.
Sorption properties of titanium silicate molecular sieves (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSorption properties of titanium silicate molecular sievesS. P. Mirajkar, A. Thangaraj, and V. P. ShiralkarCite this: J. Phys. Chem. 1992, 96, 7, 3073–3079Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/j100186a055https://doi.org/10.1021/j100186a055research-articleACS PublicationsRequest reuse permissionsArticle Views420Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The properties and uses of clays which swell in organic solvents (1983)

Abstract The exchangable cations present on certain montmorillonites can be replaced by long-chain quarternary ammonium cations, and the resulting clays have the important property of being able to swell and disperse in a variety of organic solvents. Organophilic clays have a wide range of industrial applications and are, for example, important constituents of oil-well drilling fluids, paints, plastics and greases; their role in these is discussed. Organophilic clays have been extensively studied for about 50 years, but neither the structure nor the mechanisms by which they swell and disperse in organic solvents are clearly understood. An attempt is made to interpret the industrial applicatons in terms of published ideas concerning the structure and swelling properties of organophilic clays.
Some Properties of Hepatitis B Core Antigen Isolated from Serum of Infected Humans (1978)

The nucleocapsid of Dane particles (= hepatitis B core antigen; HBcAg) was isolated from human sera either positive or negative for e-antigen (HBeAg)--an apparent marker for the level of infectious hepatitis B virus in serum. HBcAg from the HBeAg-positive serum pool consisted of two distinct populations of particles, one with a buoyant density (d) of 1.358 g/ml and a sedimentation coefficient (S20, w) of approximately 110, and another with d = 1.25 to 1.30 g/ml and S20, w approximately 70. Only the latter type of particles was isolated from an HBeAg-negative serum pool. HBcAg was labelled with 125I-p-hydroxyphenylpropionic acid N-hydroxysuccinimide ester, dissociated and analysed by polyacrylamide gel electrophoresis. One major and one minor polypeptide with apparent mol. wt. of 16000 +/- 500 and 68000, respectively, were detected. Another component have the properties of a glycolipid with a mol. wt. in the order of 10(3) was observed. After isoelectric focusing, HBcAg was recovered in fractions with a pH between 4.0 and 5.8, suggesting heterogeneity in isoelectric points.
SURGNET: An Integrated Surgical Data Transmission System for Telesurgery (2009)

Remote surgery information requires quick and reliable transmission between the surgeon and the patient site. However, the networks that interconnect the surgeon and patient sites are usually time varying and lossy which can cause packet loss and delay jitter. In this paper we propose SURGNET, a telesurgery system for which we developed the architecture, algorithms and implemented it on a testbed. The algorithms include adaptive packet prediction and buffer time adjustment techniques which reduce the negative effects caused by the lossy and time varying networks. To evaluate the proposed SURGNET system, at the therapist site, we implemented a therapist panel which controls the force feedback device movements and provides image analysis functionality. At the patient site we controlled a virtual reality applet built in Matlab. The varying network conditions were emulated using NISTNet emulator. Our results show that even for severe packet loss and variable delay jitter, the proposed integrated synchronization techniques significantly improve SURGNET performance.
A software protection method based on instruction camouflage (2005)

This paper presents a method in which program analysis by a malicious user (attacker) is made difficult by camouflaging (hiding) a large number of instructions contained in the program. In the proposed method, an arbitrary instruction (target) in the program is camouflaged by a different instruction. Using the self-modification mechanism in the program, the original instruction is restored only in a certain period during execution. Even if the attacker attempts an analysis of the range containing the camouflaged instruction, it is impossible for him to correctly understand the original behavior of the program unless he notices the existence of the routine that rewrites the target (restoring routine). In order to make the analysis a success, the range containing the restoring routine must be analyzed, and the attacker is forced to analyze a wider range of the program. The proposed method can easily be automated, and the number of targets can be specified arbitrarily according to the required degree of protection and the acceptable degradation of execution efficiency. © 2005 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 89(1): 47–59, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecjc.20141
Analysis and VLSI architecture of a nonlinear edge-preserving noise-smoothing image filter (1991)

A nonlinear, nonrecursive, two-dimensional filter for edge preserving and noise smoothing of images is developed. The filter is applied over a 3 × 3 window of pixels and uses a thresholding operation. It is tested against other filters of the same class and its efficiency is proven by simulation. Analytical evaluation is also performed using a first-order stochastic Markov model. The computational requirements lead to the use of special purpose hardware for real-time implementation. A massively parallel array structure is proposed and the basic processing element realising the filtering operation is implemented in CMOS VLSI using minimal hardware components.
The Preparation and Crystal Data of the Cadmium Silicates CdSiO<sub>3</sub>, Cd<sub>2</sub>SiO<sub>4</sub>, and Cd<sub>3</sub>SiO<sub>5</sub> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation and Crystal Data of the Cadmium Silicates CdSiO3, Cd2SiO4, and Cd3SiO5L. S. Dent Glasser and F. P. GlasserCite this: Inorg. Chem. 1964, 3, 9, 1228–1230Publication Date (Print):September 1, 1964Publication History Published online1 May 2002Published inissue 1 September 1964https://pubs.acs.org/doi/10.1021/ic50019a005https://doi.org/10.1021/ic50019a005research-articleACS PublicationsRequest reuse permissionsArticle Views296Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The impact of information technology on histopathology (2000)

Pathology is one of the most computer intensive areas of medicine and as a result diagnostic pathologists in histopathology have often been at the cutting edge of computer literacy. The majority of laboratories use laboratory information systems to issue and store pathology reports. Many of these systems provide the diagnostician with the ability to retrieve reports and cases using coding systems such as SNOMED, but more advanced computer facilities that might assist the pathologist in the diagnosis or interpretation of a case are often lacking. In recent years advances in computer technology have begun to have a much wider impact on the practice of medicine and newer technologies are beginning to find their way into the reporting room. In this review, I cover some of the recent and emerging advances in IT that have the potential to revolutionize the practice of diagnostic histopathology in the next 5 years. The major area of telepathology has been a subject of several recent reviews and will not be covered here.
Myogenic nitric oxide synthase activity in canine lower oesophageal sphincter: morphological and functional evidence (1998)

1. Studies on canine lower oesophageal sphincter (LOS) evaluated the existence and function of a myogenic, nitric oxide synthase (NOS) by use of immunocytochemistry for NOS isozymes, NADPH-d histochemistry, [3H]-L-arginine to [3H]-L-citrulline transformation. In addition, functional studies in the muscle bath were performed. 2. Smooth muscle bundles or freshly isolated smooth muscle cells of LOS were NADPH-d reactive but did not recognize some antibodies against neural, endothelial or inducible NOS. NADPH-d reactivity and immunoreactivity to a neural NOS antibody were colocalized in LOS enteric nerves. Muscle plasma membrane-enriched fractions from fresh and cultured LOS cells converted [3H]-L-arginine to [3H]-L-citrulline; activity was mostly Ca2+/calmodulin-dependent. 3. N-Nitro-L-arginine (L-NOARG) persistently increased tone (blocked by L-arginine) in muscle strips despite blockade of nerve function. Nifedipine prevented or abolished L-NOARG-induced, but not carbachol-induced, contraction showing that tone increase by L-NOARG required functional L-Ca channels. 4. Membrane-bound, myogenic NOS in canine LOS may release NO continuously when Ca2+ entry through L-Ca channels occurs under physiological conditions and thereby modulate tone in LOS.
Hydrogel keratophakia: measurement of intraocular pressure. (1986)

Une tonometrie a l'aplanation et une pneumotonometrie ont ete pratiquees sur des yeux operes et non operes de singes. Les resultats montrent que le tonus oculaire peut etre mesure de facon fiable et facile par ces 2 techniques dans les yeux porteurs d'implants hydrogel
A Defect in the Intramolecular and Intermolecular Cross-linking of Collagen Caused by Penicillamine (1969)

Abstract The neutral salt-soluble collagen which accumulates in the tissues of animals treated with penicillamine does not differ from normal in amino acid composition, specific optical rotation, and melting temperature. It has higher intrinsic viscosity, possibly due to a contamination with higher molecular weight aggregates originating from the depolymerization of insoluble collagen. In contrast to the aldehyde-deficient lathyritic collagen, the penicillamine collagen has an aldehyde content greater than normal and rapidly forms stable cross-links in vitro. Binding studies, involving film and equilibrium dialysis, revealed a significant interaction between collagen and compounds with a free α-aminothiol structure. The binding capacity of various collagens tested is proportional to their aldehyde content, and reduction with NaBH4 eliminates this interaction. Reduction of these aldehydes, amidination of the e-amino groups of lysine and hydroxylysine, or addition of sodium bisulfite (10-4 m) causes neutral salt-soluble collagen to behave like lathyritic collagen. It is postulated that the inhibition of cross-linking caused by penicillamine in vivo and in vitro involves a reversible interaction with the aldehydes present in tropocollagen to form a thiazolidine type complex, since compounds with adjacent free sulfhydryl and amino groups are necessary for activity. The solubilizing effect exhibited by α-amino-β-thiols on an incompletely cross-linked form of insoluble collagen as well as the generation of soluble collagen with a high aldehyde content can be attributed to the splitting of a Schiff's base intermediate. The structure which is responsible for the initial stabilization of the collagen fiber can be reduced with NaBH4, rendering the collagen insoluble in penicillamine.
Personalised route-map generation using crowd sourced GPS traces (2014)

Developing a robust and well-informed cellular phone based transportation system comes with increasing popularity and availability of digital maps that has certainly made navigation simpler. But that comes with a serious limitation of narrow unknown paths which does not hold any place on these maps. The drawbacks of inaccuracy of road geometry and the lack of fine-grained information hampers a route guidance system. In this paper, we present an approach to build high-precision maps from the GPS traces of crowd, equipped with differential GPS receivers, for updating existing paths and adding new path segments scaled according to digital map. Due to decreasing cost, we expect that large volume of GPS traces can be gathered for building up new road segments. Our approach is to build a smart system where the crowd traces will be uploaded on the server through a cellular user-interface, to generate a fine-grained map based on human labelling.
Football Shot Detection using Convolutional Neural Networks (2019)

In this thesis, three different neural network architectures are investigated to detect the action of a shot within a football game using video data. The first architecture uses con- ventional convolution and pooling layers as feature extraction. It acts as a baseline and gives insight into the challenges faced during shot detection. The second architecture uses a pre-trained feature extractor. The last architecture uses three-dimensional convolution. All these networks are trained using short video clips extracted from football game video streams. Apart from investigating network architectures, different sampling methods are evaluated as well. This thesis shows that amongst the three evaluated methods, the ap- proach using MobileNetV2 as a feature extractor works best. However, when applying the networks to a video stream there are a multitude of challenges, such as false positives and incorrect annotations that inhibit the potential of detecting shots.
Lime-based restoration paints: characterization and evaluation of formulations using a native species from the Amazon flora and PVA-based glue as additives (2017)

Abstract Based on historic documents, two lime-based paint formulations were produced in laboratory in order to evaluate their basic characteristics as restoration materials for historic buildings with lime-based components. The paints were made basically with hydrated lime, clay, water and linseed (Linum usitatissimum L.) oil, and one formulation had PVA (polyvinyl acetate)-based glue as fixative, and the other one, Couma guianensis' latex. Each paint component was characterized by XRD and FTIR, and color and specular gloss measurements were performed on both paints. A preliminary assessment of the paints was conducted using the Pipe Method, the salt crystallization test, visual analysis for dustiness, and analysis of microbiological growth. The results showed that the laboratory-produced paints are theoretically and technologically compatible with lime-based coatings, however, their superficial performance can be improved to achieve greater durability. This study also brings to light local materials from the Amazon region that have great potential to be used and recognized as raw materials for paints and which could also be investigated for other uses.