gebhart/patrepeval huggingface dataset:
Expression of CD200 on AML blasts directly suppresses memory T-cell function (2012)

Previous studies have shown that immunosuppression in acute myeloid leukemia (AML) is associated with changes in the adaptive immune compartment. Such changes include the suppression of memory T-cell function1 and the suppression of Th1 cytokine (TNFα, IL-2 and IFNγ)-producing cells.2 A suppressed immune response in AML is associated with a worse patient outcome and increased risk of relapse,3 as well as increased risk of infection impairing patient recovery.4 The over-expression of the immunosuppressive ligand CD200 is also associated with an increased risk of relapse in AML (hazard ratio 1.7); an observation consistent with a hypothesis in which CD200 inhibits clearance of residual disease.5, 6 As memory T-cell responses are central for tumor immunosurveillance and contribute to prolonged molecular remission,7 we carried out this study to establish how these responses were affected in AML patients over-expressing CD200 (Supplemental Table S1). We initially investigated whether CD200 expression on AML blasts influenced CD8+ T-cell cytotoxic potential and the frequency of TNFα-, IL-2- and IFNγ-producing CD4+/CD8+ memory T-cells (Supplementary Materials and Methods and Supplemental Figure S1 for gating strategy). Using CD107a as a marker of cytotoxic function, AML cells were activated with PMA/ionomycin. We show that the frequency of CD107a+CD8+ memory T-cells was significantly reduced by ~50% for CD200hi patients when compared with CD200lo AML, demonstrating that cytotoxic memory T-cell activity was compromised in CD200hi patients (Figure 1a). Furthermore, the frequencies of TNFα-, IL-2- and IFNγ-producing CD4+ memory cells were also reduced by ~50% for CD200hi patients when compared with CD200lo AML (Figure 1b), significantly so in the case of IL-2 and IFNγ. Interestingly, CD200lo patients displayed a higher IFNγ response, not only with respect to CD200hi patients but also in comparison to healthy donors, suggesting a role for this cytokine in AML, which is attenuated by CD200. No difference was observed for TNFα-, IL-2- and IFNγ-producing CD8+ memory cells between CD200hi, CD200lo and healthy donors (data not shown). CD200 has also been reported to mediate suppression of the Th1 response in chronic lymphocytic leukemia as well as solid tumors,8, 9 suggesting that CD200-mediated Th1 suppression is a central mechanism in cancer immunomodulation.
Building synthetic gene circuits from combinatorial libraries: screening and selection strategies (2013)

The promise of wide-ranging biotechnology applications inspires synthetic biologists to design novel genetic circuits. However, building such circuits rationally is still not straightforward and often involves painstaking trial-and-error. Mimicking the process of natural selection can help us to bridge the gap between our incomplete understanding of nature's design rules and our desire to build functional networks. By adopting the powerful method of directed evolution, which is usually applied to protein engineering, functional networks can be obtained through screening or selecting from randomised combinatorial libraries. This review first highlights the practical options to introduce combinatorial diversity into gene circuits and then examines strategies for identifying the potentially rare library members with desired functions, either by screening or selection.
Social (media) jet lag (2015)

By nature, we are circadian creatures whose bodies' biological clocks drive numerous physiological, mental, and behavioral rhythms. Simultaneously, we are social beings. Accordingly, our internal circadian timings experience interference from externally determined factors such as work schedules and social engagements, and digital connectivity imports additional social constraints that can further misalign our individual body clocks. Misalignment between biological and social time causes social jet lag [50], which has serious physical and mental health consequences. It particularly impacts our sleep processes and neurobehavioral functioning. Examining the interplay between biological rhythms and technology-mediated social interactions, we find that technology may both modulate and reflect circadian rhythms. We also leverage such social-sensor data to infer sleep-related behaviors and disruptions and to analyze variations in attention, cognitive performance, and mood following (in)adequate sleep. We conclude with recommendations for designing technologies attuned to our innate biological traits.
Artificial Minds (1995)

From the Publisher:
Stan Franklin is the perfect tour guide through the contemporary interdisciplinary matrix of artificial intelligence, cognitive science, cognitive neuroscience, artificial neural networks, artificial life, and robotics that is producing a new paradigm of mind. Along the way, Franklin makes the case for a perspective that rejects a rigid distinction between mind and non-mind in favor of a continuum from less to more mind, and for the role of mind as a control structure with the essential task of choosing the next action. Selected stops include the best of the work in these different fields, with the key concepts and results explained in just enough detail to allow readers to decide for themselves why the work is significant. Major attractions include animal minds, Newell's SOAR, the three Artificial Intelligence debates, Holland's genetic algorithms, Wilson's Animat, Brooks' subsumption architecture, Jackson's pandemonium architecture, Ornstein's multimind, Minsky's society of mind, Maes's behavior networks, Edelman's neural Darwinism, Drescher's schema mechanisms, Kanerva's sparse distributed memory, Hofstadter and Mitchell's Copycat, and Agre and Chapman's deictic representations.
SOLUTIONS OF METALS IN NON-METALLIC SOLVENTS; I. GENERAL PROPERTIES OF SOLUTIONS OF METALS IN LIQUID AMMONIA. (1907)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSOLUTIONS OF METALS IN NON-METALLIC SOLVENTS; I. GENERAL PROPERTIES OF SOLUTIONS OF METALS IN LIQUID AMMONIA.Charles A. KrausCite this: J. Am. Chem. Soc. 1907, 29, 11, 1557–1571Publication Date (Print):November 1, 1907Publication History Published online1 May 2002Published inissue 1 November 1907https://pubs.acs.org/doi/10.1021/ja01965a003https://doi.org/10.1021/ja01965a003research-articleACS PublicationsRequest reuse permissionsArticle Views946Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Visible/Near-infrared Reflectance and Interactance Spectroscopy for Detection of Abnormal Poultry Carcasses (1993)

The results of the development of a nondestructive and noninvasive technique for the detection of abnormal poultry carcasses using a diode array spectrophotometer system were presented. Visible/near-infrared reflectance and interactance spectra (500 to 1113 nm) for both sides of the breast of normal, septicemic, and cadaver poultry carcasses were obtained using a fiber optic probe with the spectrophotometer. Optimal wavelengths for correlating the spectral reflectance and interactance and second difference with the condition of the poultry carcasses were obtained. In general, differentiating between the normal and cadaver carcasses was more accurate than differentiating between normal and septicemic and between septicemic and cadaver. It was concluded that this technique can be used to separate normal carcasses from the abnormal (septicemic and cadaver) ones with good accuracy. The model based on second differences of interactance spectra, which requires 24 wavelength readings, yielded a classification accuracy of 93.3% for normal carcasses and 96.2% for the abnormal carcasses. Alternative decision criteria could be chosen so that none of abnormal carcasses were misclassified as normal. However, for a sensor limited to four wavelength readings, the model based on the reflectances should be used. The reflectance model required four wavelength readings and provided a classification accuracy of 94.4% for normal carcasses and 93.1% for abnormal carcasses.
15.2: 2.0 inch a‐Si:H TFT‐LCD with Low Noise Integrated Gate Driver (2005)

Abstract We developed a 2.0 inch, QCIF (160×128×RGB), a‐Si:H TFT‐LCD with a low noise gate driver integrated on glass substrate. By simulation and measurement, the proposed gate driver was found to be noise‐free compared to conventional one. A new gate driver can make it possible to perform operation regardless of the voltage coupling from other voltage sources.
Impact of obesity on glucose and lipid profiles in adolescents at different age groups in relation to adulthood (2002)

This study confirmed that adolescents aged between 13 and 15 years old of both sexes with a BMI >or= 85th percentile are at increased risk of becoming overweight or obese adults and presenting abnormal glucose and lipid profiles as adults. This emphasizes the importance of early detection and intervention directed at treatment of obesity to avert the long-term consequences of obesity on the development of cardiovascular diseases.
Appearance and Characterization of Lipoprotein X during Continuous Intralipid Infusions in the Neonate (1979)

The development of hyperphospholipidemia and hypercholesterolemia was studied in infants that required total parenteral nutrition and given a continuous infusion of Intralipid, (1-4 g/kg body wt per 24 h. Detailed studies were carried out on infusion periods lasting 1-10 d. After 24 h there was a marked increase in plasma free cholesterol (68%) and phospholipid (77%) concentrations. Based on the amount of cholesterol in Intralipid, and the rate of infusion, it was estimated that at least 50% of the plasma cholesterol increment during 64-h infusions was derived from endogenous sources. By contrast, the hyperphospholipidemia could be attributed to the Intralipid as the rise in plasma was calculated to be equivalent to only 16% of the exogenous phospholipid infused. Approximately 10% of the phospholipid in Intralipid was in a triglyceride-free mesophase form with a free cholesterol:phospholipid molar ratio of 0.063. There were no systematic changes in plasma concentrations of cholesterol ester or triglyceride during Intralipid infusions. The increase in free cholesterol and phospholipid was localized in the low density lipoproteins (d = 1.006-1.063 g/ml). The presence of lipoprotein X (Lp-X) in the low density lipoprotein fraction was demonstrated by electrophoresis in agar and by isolation and chemical characterization with hydroxylapatite chromatography. Isoelectric focusing of urea-soluble protein of Lp-X revealed that albumin and apolipoproteins CII and CIII were major components, whereas apolipoprotein E and AI were minor constituents. The abnormal lipoprotein was apparent by 16 h during 64 h of infusion. After 6 d of continuous infusions the free cholesterol in Lp-X was 30+/-10 mg/dl (mean+/-SD), which represents a total Lp-X mass of 90 mg/dl. After cessation of the infusion, Lp-X, as monitored by electrophoresis in agar, disappeared within 72-96 h. Thus, during infusion of Intralipid in infants at rates commonly employed, the capacity of the clearance mechanisms for phospholipid are exceeded, which causes the accumulation of phospholipid and free cholesterol in the form of Lp-X particles. It is suggested that mesophase phospholipids in Intralipid may play a significant role in this process.
A load balanced SIMD polygon renderer (1995)

This document describes a parallel polygon rendering algorit.hrn designed for a SIMD supercomputer architecture. The overall algorithm can be implemented on any SIMD machine; in this paper, we expand upon an implementation which is specific to the Princeton Engine, a product of the David Sarnoff Research Center. The algorithm has a number of improvements over previously developed SIMD renderers in that load balancing is considered and designed into the algorithm with minimal overhead.
CURATIVE RECONSTRUCTION OF A GIANT MIDBASILAR TRUNK ANEURYSM WITH THE PIPELINE EMBOLIZATION DEVICE (2009)

The PED provides a safe and definitive constructive treatment option for large, giant, and fusiform/circumferential aneurysms. The PED can achieve complete aneurysm occlusion without embolization coils. When applied judiciously, the PED may be used safely in vascular segments that give rise to eloquent perforators.
Register allocation for software pipelined multidimensional loops (2008)

This article investigates register allocation for software pipelined multidimensional loops where the execution of successive iterations from an n -dimensional loop is overlapped. For single loop software pipelining, the lifetimes of a loop variable in successive iterations of the loop form a repetitive pattern. An effective register allocation method is to represent the pattern as a vector of lifetimes (or a vector lifetime using Rau's terminology [Rau 1992]) and map it to rotating registers. Unfortunately, the software pipelined schedule of a multidimensional loop is considerably more complex and so are the vector lifetimes in it. In this article, we develop a way to normalize and represent the vector lifetimes, which captures their complexity, while exposing their regularity that enables a simple solution. The problem is formulated as bin-packing of the multidimensional vector lifetimes on the surface of a space-time cylinder. A metric, called distance, is calculated either conservatively or aggressively to guide the bin-packing process, so that there is no overlapping between any two vector lifetimes, and the register requirement is minimized. This approach subsumes the classical register allocation for software pipelined single loops as a special case. The method has been implemented in the ORC compiler and produced code for the IA-64 architecture. Experimental results show the effectiveness. Several strategies for register allocation are compared and analyzed.
ChemInform Abstract: WITTIG‐HORNER REACTION IN HETEROGENEOUS MEDIA; 1. AN EASY SYNTHESIS OF ETHYL α‐HYDROXYMETHYLACRYLATE AND ETHYL α‐HALOMETHYLACRYLATES USING FORMALDEHYDE IN WATER (1983)

Abstract Die Kondensation des Phosphonoessigsäureethylesters (I) mit Formaldehyd in Gegenwart von Kaliumcarbonat führt zum α‐Hydroxymethylacrylsäureethylester (II) und wenig Acrylsäureethylester (III).
A query algebra for object-oriented databases integrating versions (2002)

Presents an algebra to query object-oriented databases that integrate versions. This algebra rests on an object-oriented data model which permits, by means of versions, the description of both value and schema evolutions for entities. The specificities of versions are taken into account. So, versions describing an entity may be queried either by considering the derivation hierarchy they belong to (all the entity states are considered) or independently, one from another (only some entity states are considered).
The Structure of a New Metabolite from Aspergillus versicolor (1969)

Journal Article The Structure of a New Metabolite from Aspergillus versicolor Get access Yuichi Hatsuda, Yuichi Hatsuda Faculty of Agriculture, University of Tottori, Tottori, Japan Search for other works by this author on: Oxford Academic Google Scholar Takashi Hamasaki, Takashi Hamasaki Faculty of Agriculture, University of Tottori, Tottori, Japan Search for other works by this author on: Oxford Academic Google Scholar Masayoshi Ishida, Masayoshi Ishida Faculty of Agriculture, University of Tottori, Tottori, Japan Search for other works by this author on: Oxford Academic Google Scholar Seikichi Yoshikawa Seikichi Yoshikawa Faculty of Agriculture, University of Tottori, Tottori, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 33, Issue 1, 1 January 1969, Pages 131–133, https://doi.org/10.1080/00021369.1969.10859290 Published: 01 January 1969 Article history Received: 26 October 1968 Published: 01 January 1969
Olefin Coordination Compounds of Rhodium: The Barrier to Rotation of Coordinated Ethylene and the Mechanism of Olefin Exchange (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOlefin Coordination Compounds of Rhodium: The Barrier to Rotation of Coordinated Ethylene and the Mechanism of Olefin ExchangeRichard. CramerCite this: J. Am. Chem. Soc. 1964, 86, 2, 217–222Publication Date (Print):January 1, 1964Publication History Published online1 May 2002Published inissue 1 January 1964https://pubs.acs.org/doi/10.1021/ja01056a022https://doi.org/10.1021/ja01056a022research-articleACS PublicationsRequest reuse permissionsArticle Views849Altmetric-Citations223LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Immigrant-trade links, transplanted home bias and network effects (2007)

Macro-level data for the US and 73 trading partners spanning the years 1980 to 2001 is used with a gravity specification to investigate the influence of immigration on bilateral trade. Prior research has identified immigrant stocks as a significant determinant of trade; however, this study indicates that the US immigrant-trade link is driven by immigration from relatively low income countries. A 10% increase in the immigrant stock is found to generate respectively 4.7 and 1.5% increases in domestic imports from and exports to the typical low income home country. The observed link is decomposed into two hypothesized channels–network effects and transplanted home bias. Considerable variation in per-immigrant trade effects is found across home countries: imports from the typical low income home country are estimated to increase by up to $2057 due to transplanted home bias and by as much as $2967 as a result of network effects, while exports rise by up to $910 as a result of networks.
Text S1 - A Dynamical Systems Model for Combinatorial Cancer Therapy Enhances Oncolytic Adenovirus Efficacy by MEK-Inhibition (2015)

<p>Contents: 1) parameter estimation; 2) parameter convergence; 3) model fitness; 4) interpolation methods; 5) model simulations; 6) MATLAB syntax for ordinary differential equation model; 7) MIFlowCyt outline.</p> <p>(0.89 MB PDF)</p>
The nature of the prostaglandin-producing mononuclear cell in human peripheral blood. (1981)

The purpose of this investigation was to identify the human peripheral mononuclear cell responsible for PGE production. The prostaglandin-producing cell had the following characteristics: (1) was glass adherent; (2) was removed by techniques that effectively removed phagocytic cells (carbonyl iron); and (3) was not an E-rosette cell. Furthermore, the peripheral mononuclear cells that contain cytoplasmic PGE by indirect immunofluorescence also ingest latex particles. B and T lymphoid cell lines did not produce large quantities of PGE. Mononuclear cells separated on discontinuous BSA gradients varied greatly in their ability to produce prostaglandin (low density > high density). These data constitute strong evidence that the majority of PGE produced in peripheral mononuclear cell suspensions emanates from a population of low-density monocytes.
<sup>18</sup>F-FDG PET/CT, <sup>99m</sup>Tc-MIBI, and MRI in Evaluation of Patients with Multiple Myeloma (2008)

In whole-body analysis, (18)F-FDG PET/CT performed better than (99m)Tc-MIBI in the detection of focal lesions, whereas (99m)Tc-MIBI was superior in the visualization of diffuse disease. In the spine and pelvis, MRI was comparable to (18)F-FDG PET/CT and (99m)Tc-MIBI in the detection of focal and diffuse disease, respectively. Because myelomatous lesions may often occur out of spinal and pelvic regions, MRI should be reserved to the evaluation of bone marrow involvement of these districts, whereas (18)F-FDG PET/CT can significantly contribute to an accurate whole-body evaluation of MM patients. Finally, whole-body (99m)Tc-MIBI, despite its limited capacity in detecting focal lesions, may be an alternative option when a PET facility is not available.
340 GHz On-Chip 3-D Antenna With 10 dBi Gain and 80% Radiation Efficiency (2015)

This paper discusses the design methodologies of a 340 GHz on-chip 3-D antenna. Firstly, a high-gain and high-radiation efficiency substrate integrated waveguide (SIW) cavity backed on-chip antenna is designed using a standard 0.13- μm SiGe BiCMOS technology. Then, a low-permittivity supporter and a dielectric resonator (DR) are vertically stacked on the proposed on-chip antenna, forming a 3-D Yagi-like antenna to further enhance the gain and radiation efficiency. The measurements showed that the proposed antenna achieved a peak gain of ~10 dBi and radiation efficiency of ~80% at 340 GHz; the impedance bandwidth is ~12% with the use of dielectric resonator antenna (DRA) and the Yagi-like structure. The antenna size is ~0.7×0.7 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Allergen‐induced bronchial inflammation is associated with decreased levels of surfactant proteins A and D in a murine model of asthma (2001)

These results indicated the involvement of pulmonary surfactant proteins in the allergic bronchial inflammation of sensitized mice.
Solar cell calibration and characterization: simplified DSR apparatus (1988)

A simplified differential spectral responsivity (DSR) apparatus that is easily operated and well suited for installation and use in an industrial laboratory is describes, its performance is discussed, and typical results are presented. The authors also describe its application to the measurement of effective diffusion lengths of the minority carriers in the base using the so called constant differential photosignal method, which is a modified surface photovoltage method. The special features of the DSR method and its applicability to nonlinear solar cells (i.e. cells with a nonlinear short-circuit current irradiance characteristic) are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>