gebhart/patrepeval huggingface dataset:
Development of hydrogel patch for controlled release of alpha‐hydroxy acid contained in tamarind fruit pulp extract (2005)

Synopsis The aim of this study was to develop hydrogel patch using crosslinked chitosan-starch as polymeric matrix for controlling the release of the natural alpha-hydroxy acid (AHA) contained in the extract of tamarind's fruit pulp. The chitosan (MW 100 000) was blended with corn, tapioca or rice starch in various ratios and then crosslinked with glutaraldehyde. The physical characteristics, mechanical resistance, bio-adhesion property and surface morphology of the prepared hydrogel patches with and without the extract were investigated. The release patterns of the hydrogel patches containing the extract were investigated by measuring the amount of tartaric acid, a major AHA present in the tamarind's fruit pulp extract, accumulated in the receptor medium of the vertical diffusion cell at various time intervals over a period of 6 h. The results indicated that the formulations of chitosan : corn starch 4.5 : 0.5 with glutaraldehyde 0.02% w/w (C(4.5)C(0.5)G(0.02)) or 0.04% w/w (C(4.5)C(0.5)G(0.04)), chitosan : tapioca starch 4.5 : 0.5 with glutaraldehyde 0.04% w/w (C(4.5)T(0.5)G(0.04)) or 0.05% w/w (C(4.5)T(0.5)G(0.05)), and chitosan : rice starch 4.5 : 0.5 with glutaraldehyde 0.04% w/w (C(4.5)R(0.5)G(0.04)) and chitosan : rice starch 4.0 : 1.0 with glutaraldehyde 0.03% w/w (C(4.0)R(1.0)G(0.03)) provided the flexible and elastic patches with good bio-adhesive property. The tensile strength values ranged from 5 to15 N mm(-2) and the elasticity ranged from 30 to 60%. The addition of the extract in these formulations significantly increased the tensile strength values of the obtained patches. The patch of C(4.0)R(1.0)G(0.03) formulation containing the extract showed relatively highest porosity, corresponding to its highest amount (12.02 +/- 0.33 mg) and rate (0.452 +/- 0.012 mg mm(-2) min(-1/2)) of tartaric acid released. The amounts of tartaric acid released from the developed hydrogel patches were proportional to a square root of time (Higuchi's model), particularly the release from C(4.0)R(1.0)G(0.03) (R(2), 0.9978 +/- 0.0020) and C(4.5)R(0.5)G(0.04) (R(2), 0.9961 +/- 0.0024) patches.
Maxillary nerve block anaesthesia via the greater palatine canal: A modified technique and case reports (1991)

A modification of the technique of maxillary nerve block (via the greater palatine canal) is discussed. This technique has been employed in the Exodontia and Oral Surgery Clinics of the United Dental Hospital of Sydney for more than 40 years. Clinical experience in that time has shown that once the greater palatine canal has been negotiated successfully, the palatal canal approach to the maxillary nerve is safe and reliable. The value of being able to anaesthetize the maxillary nerve and its branches is illustrated by the presentation of two clinical cases where local anaesthesia was achieved and the extractions performed in patients who would otherwise have required a general anaesthetic for the procedures.
Viscoelasticity in surfactant solutions. Characteristics of the micellar aggregates and the formation of periodic colloidal structures (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTViscoelasticity in surfactant solutions. Characteristics of the micellar aggregates and the formation of periodic colloidal structuresJan. Ulmius, Haakan. Wennerstroem, Lennart B. A. Johansson, Goeran. Lindblom, and Signe. GravsholtCite this: J. Phys. Chem. 1979, 83, 17, 2232–2236Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/j100480a010https://doi.org/10.1021/j100480a010research-articleACS PublicationsRequest reuse permissionsArticle Views318Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Utility of Head Computed Tomography after Minimal Head Injury (1999)

CT is a useful test in patients with minimal head injury because it may lead to a change in therapy in a small but significant number of patients. Subsequent hospital observation adds nothing to the CT results and is not necessary in patients with isolated minimal head injury.
Liraglutide and Renal Outcomes in Type 2 Diabetes (2017)

This prespecified secondary analysis shows that, when added to usual care, liraglutide resulted in lower rates of the development and progression of diabetic kidney disease than placebo. (Funded by Novo Nordisk and the National Institutes of Health; LEADER ClinicalTrials.gov number, NCT01179048 .).
Translating XML Update Language into SQL (2006)

Several techniques for translating XML query languages into SQL have been proposed but no work to date translates XML update languages into SQL since XQuery has not provided any update statements. However there is a suggestion from W3C indicating that an update version of XQuery will be proposed in the near future. Furthermore one major advantage of updating XML documents via a relational database is that the preservation of constraints can be transferred to the database engine; thus our main contributions are translating the XML update language, extending XQuery into SQL and translating recursive updates into PL/SQL. XQuery is a functional language whereas SQL is a declarative language; therefore translation cannot be performed directly so several techniques such as rewriting rules and graph mapping are used in our work.
Nucleotide sequence of mouse virus-like (VL3O) retrotransposon BVL-1 (1990)

Infectious virus-like 30s (VL30) RNA is expressed in many mouse cells and is highly inducible under a variety of hormonal and cellular stimuli (1-3) from a few of the 100-200 chromosomal loci. It is transmitted by murine retroviruses to heterologous cells where it replicates by retro-transposition. The efficiency of transposition, apparent lack of essential viral genes, and heterogeneity of VL30 loci suggest that they may be natural vectors which could provide important clues abaoaut retroviral gene transmission. Sequencing of the 5,447 bp retrotransposon BVL-1 (below) and comparison of it to a VL30 pseudo-type cDNA (4) revealed conserved retrovirus-like elements, including apparent cis-acting regulatory (replicative and transcriptional) seqences as well as other virus-like sequences thought to be involved in viral packaging and transmission [so-called psi (5) and psi-plus (6, 7) sequences]. In addition, a region homologus to the pol-int region of murine leukemia viruses was highly conserved between the two elements, and we speculate that it may therefore play a role in packaging or transmission. Finally, BVL-l contained an additional -800 bp including psi and psi- plus-like sequences not found in the previously sequenced viral pseudotype (4). Altogether, there was 77% homology between the two VL30 elements, with over 90% in conserved regions. There were no long open reading frames in BVL-1. Structural comparison to other retroviruses strongly suggested that BVL-1 arose as a defective primate or murine type retrovirus. Thus, both VL30 elements sequenced to date appear to be examples of selfish DNA (8, 9) or equivalently, selfish RNA.
Effect of competitive exclusion on transmission of Salmonella choleraesuis between early weaned pigs (1999)

Salmonella serovar Choleraesuis accounts for the vast majority of diagnosed cases of swine salmonellosis in the United States (24). Enterocolitis caused by Salmonella serovar Typhimurium ranks second as a cause of salmonellosis (24) but this organism ranks high as an important food borne pathogen. Infection by Salmonella Typhimurium and other broad host range serotypes can occur through exposure to contaminated feedstuffs, infected rodents, birds or other swine. In contrast, transmission of the host-adapted serotype, Salmonella Choleraesuis, is thought to occur primarily via contact with infected carrier pigs (24) which may shed !he palhogen from their gastrointestinal and possibly their respiratory tract.
CytA enables CryIV endotoxins of <i>Bacillus thuringiensis</i> to overcome high levels of CryIV resistance in the mosquito, <i>Culex quinquefasciatus</i> (1997)

Cry proteins produced by Bacillus thuringiensis are selective biodegradable insecticides used increasingly in bacterial insecticides and transgenic plants as alternatives to synthetic chemical insecticides. However, the potential for development of resistance and cross-resistance in target insect populations to Cry proteins used alone or in combination threatens the more widespread use of this novel pest control technology. Here we show that high levels of resistance to CryIV proteins in larvae of the mosquito, Culex quinquefasciatus, can be suppressed or reduced markedly by combining these proteins with sublethal quantities of CytA, a cytolytic endotoxin of B. thuringiensis. Resistance at the LC95 level of 127-fold for a combination of three CryIV toxins (CryIVA, B, and D), resulting from 60 generations of continuous selection, was completely suppressed by combining sporulated powders of CytA in a 1:3 ratio with sporulated powders of a CryIVA, CryIVB, and CryIVD strain. Combining the CytA strain with a CryIVA and CryIVB strain also completely suppressed mosquito resistance of 217-fold to the latter toxins at the LC95 level, whereas combination of CytA with CryIVD reduced resistance in a CryIVD-selected mosquito strain from greater than 1,000-fold to less than 8-fold. The CytA/CryIV model provides a potential molecular genetic strategy for engineering resistance management for Cry proteins directly into bacterial insecticides and transgenic plants.
Direct construction of polynomial surfaces from dense range images through region growing (1995)

article Free AccessDirect construction of polynomial surfaces from dense range images through region growing Authors: Nickolas S. Sapidis National Technical Univ. of Athens, Athens, Greece National Technical Univ. of Athens, Athens, GreeceView Profile , Paul J. Besl General Motors Research Labs., Warren, MI General Motors Research Labs., Warren, MIView Profile Authors Info & Claims ACM Transactions on GraphicsVolume 14Issue 2pp 171–200https://doi.org/10.1145/221659.221672Published:01 April 1995Publication History 59citation1,120DownloadsMetricsTotal Citations59Total Downloads1,120Last 12 Months43Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Electromagnetic Waves in Elliptic Hollow Pipes of Metal (1938)

A theoretical study of the transmission of electromagnetic waves in hollow conducting pipes of elliptic cross section, including field configurations, critical frequencies, velocities of propagation, and attenuations for the six lowest order waves. The pipe of circular cross section is treated as a special case, and the stability of waves in it for small deformation of the cross section is discussed.
Magnetocrystalline anisotropy for α'-Fe-C and α'-Fe-N films (2001)

Structural and magnetic analyses were made for /spl alpha/'-Fe-C (0-12 at.%C) and /spl alpha/'-Fe-N(0-12 at.%N) films. The results are summarized as follows: (1) epitaxial Fe-C films consisting of an /spl alpha/'-Fe-C single phase with a C content up to 12 at.% can be synthesized on MgO single crystal substrates by sputtering. (2) The change in lattice constants, a and c, as a function of the C content for the /spl alpha/'-Fe-C phase was found to be the same as that of the /spl alpha/'-Fe-N against the N content. (3) The saturation magnetization for the /spl alpha/'-Fe-C films maintains a constant value of about 210 emu/g (/spl ap/2.1 T) up to 8 at.%C. (4) The easy axis of magnetization of /spl alpha/'-Fe-N corresponds to the c-axis of the bct structure. Even though the /spl alpha/'-Fe-C phase has the same bct structure as the /spl alpha/'-Fe-N, the easy axis of magnetization lies in the [001] plane, (5) the value of the uniaxial magnetocrystalline anisotropy, K, for /spl alpha/'-Fe-C is -2/spl times/10/sup 9/ erg/cm/sup 3/ independent of the C content, and the magnetocrystalline anisotropy constant, K/sub 3/ decreases with increasing C content and is about 3/spl times/10/sup 5/ erg/cm/sup 3/ at 12 at.%C. (6) the value of the coercive force for the /spl alpha/'-Fe-C films with C content more than 4 at.% is about 2 Oe. From this study, it is found that the /spl alpha/'-Fe-C films with 4-8 at.%C are promising candidates for use as writing head material.
Anti-Angiotensin and Hypoglycemic Treatments Suppress Liver Metastasis of Colon Cancer Cells (2011)

The effect of diabetic conditions on liver metastasis was examined using CT26 mouse colon cancer cells. CT26 cells produced angiotensin (A)-I and A-II from angiotensinogen; the production was abrogated by inhibitors of renin and chymase. Renin expression and A-II production increased with an increase in the concentration of glucose in the medium. In a streptozotocin-induced BALB/c mouse diabetes model that was fed a high-calorie diet, the blood sugar level increased and was associated with an increasing size and number of CT26 liver metastases. In this diabetic mouse model, liver metastasis of CT26 cells was suppressed by anti-angiotensin treatment with a chymase inhibitor, a renin inhibitor, and an A-II receptor blocker. Moreover, concurrent hypoglycemic and anti-angiotensin treatments showed a synergistic inhibitory effect on CT26 cell liver metastasis. These results suggest that angiotensin activation ability associated with diabetic conditions enhances liver metastasis of colon cancer. Therefore, treatment with anti-angiotensin and hypoglycemic agents might be relevant for baseline management of colon cancer patients with the diabetic condition for the prevention of liver metastasis. This scheme needs to be examined in a clinical setting.
Melting Within a Spherical Enclosure (1982)

Melting of a phase change material within a spherical enclosure is considered. The phase change material is initially at its saturation temperature. Suddenly the enclosure temperature is increased to a fixed value. The density of the solid is assumed to exceed the density of the liquid, the implication being that the solid continually drops toward the bottom of the shell as melting progresses. This motion of the solid generates a flow field within the liquid. A mathematical model is developed and confirmed by experimental evidence. The interface positions and the temperature profiles for various Stefan and Fourier numbers are determined, and the energy storage characteristics are studied. It is found that the convective effects can be neglected only at small Stefan numbers.
Exercise training decreases plasma levels of soluble CD40 ligand and P-selectin in patients with chronic heart failure (2008)

Our findings suggest a potent downregulatory effect of exercise training on platelet-mediated inflammation in patients with chronic heart failure. Further studies are needed to clarify the clinical significance of these findings.
Introduction (2012)

If you are sick, who decides what treatment you should receive? Who controls where treatment should be given and by whom? Do you as a patient have a choice, or is it all in the hands of doctors, civil servants or even politicians? If you were seeking help for drug dependence, would the same rules apply? This book examines how decisions about addiction treatment have been made in England. In particular, it asks how the conflicts that arose between a few doctors towards the end of the last century affected national addiction treatment policies.
HoloCollab (2017)

Today's industrial jobs require a skilled and trained workforce as tasks such as maintenance, service, and repair are becoming more complicated and more demanding. Therefore, both education and training for executing these tasks are becoming more important. Usually training is conducted on-site at designated training facilities with physical hardware. However, on-site hands-on training can be expensive as it requires designated training facilities that have to be maintained and need to be traveled to. With Augmented Reality (AR) becoming a substantial part of modern day manufacturing, using AR-based systems to train new workforces is becoming increasingly popular. In this paper, we investigate different training environments that use AR-based support during workforce training. We draw the design space for a shared collaborative AR-based learning space, and present the concept and implementation of HoloCollab which combines having a scalable virtual representation of an industrial scenario, such as assembly, with the benefit of having a trainer on-site with a trainee.
Detection of divergences in polyethylene resins fabrication by means of the modified stepwise isothermal segregation technique (1999)

The selective crystallization behavior of a series of commercial medium- and high-density polyethylene resins has been studied by means of an original modified procedure of the stepwise isothermal segregation technique using differential scanning calorimetry. The technique consists of a sequenced multiple-stage stepwise thermal treatment of the materials allowing separation of the macromolecules with respect to their length-to-branching content and distribution. It is assumed that such a separation process gives an image of the proportion of specific crystallizable species, which are in turn responsible for slow crack growth resistance of the resins under study. A drift molecular parameter is calculated from a combination of the crystallization data at 119°C and 114°C. This molecular parameter is capable of revealing some divergences regarding the fabrication of a commercial polyethylene resin within a decade. Such divergences are well correlated with premature brittle failures under hydrostatic pressure testing of a series of correctly extruded pipes. Furthermore the drift molecular parameter allows a ranking of different medium- to high-density polyethylene resins—the lower this parameter the better the slow crack growth resistance of the materials. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 73: 2103–2112, 1999
Hypolipidemic 2-[4-(1,1-dimethylethyl)phenyl]-4H-3,1-benzoxazin-4-ones. Structure-activity relationships of a novel series of high-density lipoprotein elevators (1989)

The preparation and plasma lipid altering characteristics of a series of 4H-3,1-benzoxazin-4-ones are described. Hypocholesterolemic, hypotriglyceridemic, and high-density-lipoprotein elevating properties are found for derivatives bearing a 4-(1,1-dimethylethyl)phenyl group at the 2-position, and this activity is displayed in both hypercholesterolemic and in normolipidemic rats when the ring system is substituted at position 6 with hydrogen, methyl, chloro, or iodo groups, and is optimal when the 6-position is substituted by a bromine atom. Evidence is presented suggesting that a metabolite or degradation product is responsible for the changes in lipoprotein concentration observed with active molecules of this type. Synthesis of anticipated degradation products of the active molecules gave products displaying the expected in vivo activity, but no improvement in the narrow therapeutic margin of the best compound, 6-bromo-2-[4-(1,1-dimethylethyl)phenyl]-4H-3,1-benzoxazin-4-one, was obtained.
A tight layout of the cube-connected cycles (2002)

F.P. Preparata and J. Vuillemin (1981) proposed the cube connected cycles (CCC) and in the same paper, gave an asymptotically optimal layout scheme for the CCC. We give a new layout scheme for the CCC which requires less than half of the area of the Preparata-Vuillemin layout. We also give a non trivial lower bound on the layout area of the CCC. There is a constant factor of 2 between the new layout and the lower bound. We conjecture that the new layout is optimal (minimal).
N‐acyl derivatives of ϵ‐caprolactam (1964)

Abstract The preparation and properties of a number of new N‐acylcaprolactams are described. These compounds were found to be catalysts for the anionic polymerization of caprolactam.
A high-performance alginate hydrogel binder for the Si/C anode of a Li-ion battery (2014)

An alginate hydrogel binder is prepared through the cross linking effect of Na alginate with Ca(2+) ions, which leads to a remarkable improvement in the electrochemical performance of the Si/C anode of a Li-ion battery.
The role of NOTCH1 signaling in T-ALL (2009)

The identification of activating mutations in NOTCH1 in over 50% of T-cell acute lymphoblastic leukemias (T-ALL) has generated major interest in the elucidation of the mechanisms of transformation downstream of oncogenic NOTCH and in the targeting of the NOTCH signaling pathway in this disease. Small molecule gamma-secretase inhibitors (GSIs) block NOTCH1 signaling in T-ALL lymphoblasts, yet the clinical development of GSIs has been held back by the development of gastrointestinal toxicity and their weak antileukemic effects against human T-ALL. However, new therapeutic strategies aiming to optimize the use of anti-NOTCH1 therapies for T-ALL, including combination therapies with molecularly targeted drugs and glucocorticoids, have started to emerge as a result of improved understanding of the molecular mechanisms that mediate the effects of GSIs in leukemic cells and the intestinal epithelium. This review focuses on the molecular basis of NOTCH1-induced transformation, the mechanisms of action of oncogenic NOTCH1 and clinical significance of NOTCH1 mutations in T-ALL.