gebhart/patrepeval huggingface dataset:
Attribute-driven edge bundling for general graphs with applications in trail analysis (2015)

Edge bundling methods reduce visual clutter of dense and occluded graphs. However, existing bundling techniques either ignore edge properties such as direction and data attributes, or are otherwise computationally not scalable, which makes them unsuitable for tasks such as exploration of large trajectory datasets. We present a new framework to generate bundled graph layouts according to any numerical edge attributes such as directions, timestamps or weights. We propose a GPU-based implementation linear in number of edges, which makes our algorithm applicable to large datasets. We demonstrate our method with applications in the analysis of aircraft trajectory datasets and eye-movement traces.
Rap1 controls cell adhesion and cell motility through the regulation of myosin II (2007)

We have investigated the role of Rap1 in controlling chemotaxis and cell adhesion in Dictyostelium discoideum. Rap1 is activated rapidly in response to chemoattractant stimulation, and activated Rap1 is preferentially found at the leading edge of chemotaxing cells. Cells expressing constitutively active Rap1 are highly adhesive and exhibit strong chemotaxis defects, which are partially caused by an inability to spatially and temporally regulate myosin assembly and disassembly. We demonstrate that the kinase Phg2, a putative Rap1 effector, colocalizes with Rap1-guanosine triphosphate at the leading edge and is required in an in vitro assay for myosin II phosphorylation, which disassembles myosin II and facilitates filamentous actin-mediated leading edge protrusion. We suggest that Rap1/Phg2 plays a role in controlling leading edge myosin II disassembly while passively allowing myosin II assembly along the lateral sides and posterior of the cell.
MECHANISMS UNDERLYING THE CARDIOVASCULAR ACTION OF A NEW DIHYDROPYRIDINE VASODILATOR, YC‐93 (1980)

1. The mechanisms underlying the cardiovascular action of YC-93, a new dihydropyridine vasodilator with cyclic AMP phosphodiesterase inhibitory activity, was investigated by comparing its effects with those of papaverine in various isolated, blood-perfused heart preparations of the dog. 2. In all preparations YC-93 injected into the nutrient arteries produced a dose-dependent increase in blood flow, and in this respect YC-93 was about twenty times more potent than papaverine on a weight basis. 3. In sinoatrial node preparations YC-93 injected into the sinus node artery decreased sinus rate in a dose-dependent manner, and in large doses produced atrial standstill. 4. In atrioventricular (a.v.) node preparations YC-93 injected into the a.v. node artery increased a.v. conduction time in a dose-dependent manner, and in large doses produced a second or third degree block of a.v. conduction. However YC-93 injected into the anterior septal artery scarcely affected a.v. conduction. 5. In spontaneously contracting papillary muscle preparations YC-93 injected into the anterior septal artery failed to affect ventricular automaticity in doses which markedly decreased developed tension of papillary muscles. 6. In papillary muscle preparations driven at a fixed rate YC-93 injected into the anterior septal artery produced a dose-dependent decrease in developed tension of papillary muscles. 7. Unlike YC-93, papaverine decreased a.v. conduction time in a.v. node preparations and increased developed tension of papillary muscle preparations. 8. The cardiac effects of YC-93 elucidated in the present experiments are characteristic of calcium-antagonistic vasodilators. The action of YC-93 as an inhibitor of cyclic AMP phosphodiesterase does not appear to play a role in its cardiac action.
A feedback control system for real-time formant estimation. I. Static and dynamic analysis for sinusoidal input signals (1993)

This paper presents a novel analog scheme suitable for the real-time estimation of formant frequencies. Formant tracking is based on a feedback technique which uses both the amplitude and phase characteristics of two stagger-tuned bandpass filters to give an improved dynamic behavior. The implementation of the system requires a small number of components, and is practical for low-power applications. An analysis of the static and dynamic behavior is given for sinusoidal input signals. The transient response is independent of the amplitude level of the input signal. The system is designed for second formant detection in a cochlear prosthesis system.
Solid-state reaction of iron on β-SiC (1985)

The solid-state reaction between Fe and β-SiC has been studied using Auger-electron and electron-energy-loss spectroscopies and ion sputter profiling. Fe films from submonolayer coverage to 1000 Å thickness were grown in ultrahigh vacuum, and annealed at temperatures up to 550 °C. Auger line-shape changes occurred even for initial Fe coverage at 190 °C, indicating substantial bond alteration in the SiC substrate. A 1000-Å film was largely consumed by reaction with Si and C diffused from the substrate during a 500 °C anneal, and exhibited both Fe silicide and carbide throughout most of its original volume and free C present as graphite primarily at the surface. As an aid in identifying the reaction products studied in this work, Auger line shapes were first determined for the SiLVV peak in Fe silicide and for the CKLL transition in Fe carbide.
Contrast-Enhanced Magnetic Resonance Angiography of Peripheral Vessels (1998)

In this article the relation between contrast medium (CM) application and sequence parameters will be discussed with respect to clinical use of the contrast-enhanced magnetic resonance angiography (CE-MRA) in the peripheral vessel region. The adjustment of the sequence parameters, the CM application timing and the bolus geometry is necessary for an effective use of CE-MRA. Investigation protocols for several vascular regions differ mainly corresponding to varying fields of view and slab thickness. Restrictions of increasing the measurement time are expected in peripherally localized vessels if fast arteriovenous transit time occurs. The vessel contrast depends from (1) optimal CM bolus timing and (2) bolus geometry defined by the parameters of the intravenous bolus injection (flow rate, dose and NaCl flush volume). Our study results have shown that the bolus remains compact but also shorter if a higher flow rate is being applied at equal dose. The enlargement of the NaCl flush volume has evidently caused an increased intraarterial CM concentration and a slightly bolus lengthening. The exact timing regimen requires an automated mechanical CM injection pump. In most countries, a total dose of 0.3 mmol/kg Gd is allowed for application during one investigation. Therefore, obtaining an angiogram of the entire iliac and leg region this total dose must be separated. 0.1 mmol/kg for each of the three measurements can be recommended. Otherwise, using this lower CM dose results in less spatial resolution. At least a dosage of 0.2 mmol/kg Gd is necessary to achieve a higher spatial resolution. The calculation of CM dosage should be also related to the dedicated vessel region of interest than to the body weight only.
The Removal of Non-Collagen Components from Newborn Calf Dermis with Magnesium Chloride Solution (1976)

1. Non-collagenous substances in newborn calf dermis were extracted with solutions of various concentrations of MgCI2. The total protein and hydroxyproline contents in MgCI2 extracts increased with increase in the concentration of MgCI2 in the solutions. In particular, steep increases of their contents were observed at concentrations of MgCI2 from 0.5 to 1.0 M. Total amounts of hydroxyproline in 1.0, 2.0, and 3.0 M MgCI2 extracts were equivalent to 40–50% of the hydroxyproline content in the whole connective tissue. Hexose and hexosamine contents of MgCI2 extracts increased with increase of the MgCI2 concentration. Hexuronic acid was hardly present in the residues after extractions with 0.5, 1.0, 2.0, and 3.0 M MgCI2. 2. Plasma proteins, hyaluronic acid, and dermatan sulfate were extracted at low concentrations of MgCI2. A non-collagenous protein and MgCI2-soluble collagen were extracted with 1.0, 2.0, and 3.0 M MgCI2 solutions. The disperson of collagen fibrils was observed in the residue extracted with 1.0 M MgCI2 solution by electron microscopy; the fibril structure of collagen was disordered by extraction with 2.0 and 3.0 M MgCI2 These results suggest that the dispersion and disorder of collagen fibrils lead to the release of a non-collagenous protein. Furthermore, it is suggested that the removal of hyaluronic acid and dermatan sulfate was not very effective for the solubilization of a large amount of collagen, but was suitable as a pretreatment to the extraction of a non-collagenous protein accompanied by the solubilization of a large amount of collagen. 3. The non-collagenous protein, was purified by DEAE-cellulose column chromatog-raphy. Polyacrylamide gel electrophoresis of this protein at pH 8.5 showed a single band moving to the cathode. The non-collagenous protein contained 3.7% hexose, 1.8% hexosamine, and no hexuronic acid. This protein is rich in glycine, glutamic acid, and alanine, and contains neither hydroxyproline nor hydroxylysine. Sedimentation analysis showed a single peak with 1.8 S and the molecular weight was approx. 43,000 as determined by SDS polyacrylamide gel electrophoresis.
Molecular recognition on synthetic amorphous surfaces. The influence of functional group positioning on the effectiveness of molecular recognition (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular recognition on synthetic amorphous surfaces. The influence of functional group positioning on the effectiveness of molecular recognitionK. J. Shea and T. K. DoughertyCite this: J. Am. Chem. Soc. 1986, 108, 5, 1091–1093Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/ja00265a046https://doi.org/10.1021/ja00265a046research-articleACS PublicationsRequest reuse permissionsArticle Views425Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analytical techniques for measuring contamination introduced during ion implantation (2002)

Contamination introduced during ion implantation, including transition metals, mobile ions, carbon and particulates can be deposited on the surface of the Si wafer or can be co-implanted to depths of 100s of angstroms. Tools used today to measure these contaminants include magnetic sector SIMS (Secondary Ion Mass Spectrometry), quadrupole SIMS, (TOF) Time of Flight SIMS, surface SIMS or "O" (Oxygen)-leak SIMS, Total Reflection X-Ray Fluorescence (TXRF), Vapour Phase Decomposition (VPD)-TXRF, VPD-AA (Atomic absorption) and Minority Carrier LifeTime (MCLT). In this paper, some of the advantages and shortfalls of using the above techniques are considered for the measurement of heavy metals, mobile ions, aluminium and cross-contamination of dopants introduced during ion implantation.
Primary Synchronization Signal for D2D Communications in LTE-Advanced (2015)

In this letter, we present a general construction of synchronization signals specifically tailored for device-to-device (D2D) communications in the 3GPP LTE-Advanced system. Major properties of these signals are shown analytically, and some practical examples are further analyzed numerically. It is shown that these synchronization signals can provide 50% complexity reduction of the corresponding matched filters by utilizing central-symmetry signal properties.
Determination by indirect complexometry of the main fatty acid components with Ba (II). I.- Determination of fatty acids (1968)

A new method is proposed for the determination if the main fatty acids that compose fats, after their neutralization with KOH solution, precipitating with excess of standard solution of Cl2Ba and titration of the excess of Ba (II) in the filtrate with AEDT solution of identical molarity, using o-cresolphthalein complexone as indicator.The errors found are small for lauric, myristic, palmitic, stearic, oleic and linoleic acids for concentration of 0.05M and 0.02 M.
Fano resonance of nanoparticles embedded in Fabry-Perot cavities (2013)

We present an optical structure, which consists of metal nanoparticles embedded in Fabry-Perot (F-P) cavity, to investigate the Fano resonance, which originates from the interaction between F-P mode and the plasmon modes supported by the nanoparticles. The coupling system is modeled theoretically by coupled-mode theory in time domain and the transmission properties are demonstrated numerically by the finite-difference time-domain method. The charge distribution features of the nanoparticle plasmon modes are further characterized by using boundary integral equation technology. Results show that the F-P modes can be used to active the optical inactive surface plasmon modes by breaking the mode symmetry.
Reviews (1990)

Journal Article Reviews Get access W. Shakespeare (ed. F. H. Mares ), Much Ado About Nothing . Pp. xiv + 162 (New Cambridge Shakespeare). Cambridge University Press , 1988 . Hardbound £15.00; paperbound £2.95. WILLIAM PROCTOR WILLIAMS WILLIAM PROCTOR WILLIAMS Northern Illinois University Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 37, Issue 1, March 1990, Pages 82-a–82, https://doi.org/10.1093/nq/37-1-82a Published: 01 March 1990
α<sub>1</sub>-Adrenergic receptor responses in α<sub>1AB</sub>-AR knockout mouse hearts suggest the presence of α<sub>1D</sub>-AR (2003)

Two functional alpha(1)-adrenergic receptor (AR) subtypes (alpha(1A) and alpha(1B)) have been identified in the mouse heart. However, it is unclear whether the third known subtype, alpha(1D)-AR, is also present. To investigate this, we determined whether there were alpha(1)-AR responses in hearts from a novel mouse model lacking alpha(1A)- and alpha(1B)-ARs (double knockout) (ABKO). In Langendorff-perfused hearts, alpha(1)-ARs were stimulated with phenylephrine. For ABKO hearts, phenylephrine reduced left ventricular pressure and coronary flow (to 87 +/- 2% and 86 +/- 4% of initial, respectively, n = 11, P < 0.01). These effects were blocked by prazosin and 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-8-azaspirol[4,5]decane-7,9-dione] dihydrochloride, suggesting that alpha(1D)-AR-mediated responses were present. In contrast, right ventricular trabeculae from ABKO hearts did not respond to phenylephrine, suggesting that in ABKO perfused hearts, the effects of phenylephrine were not mediated by direct actions on cardiomyocytes. A novel finding was that alpha(1)-AR stimulation caused positive inotropy in the wild-type mouse heart, in contrast to negative inotropy observed in mouse cardiac muscle strips. We conclude that mouse hearts lacking alpha(1A)- and alpha(1B)-ARs retain functional alpha(1)-AR responses involving decreases of coronary flow and ventricular pressure that reflect alpha(1D)-AR-mediated vasoconstriction. Furthermore, alpha(1)-AR inotropic responses depend critically on the experimental conditions.
Reviews (1997)

Journal Article Reviews Get access Linda Hutcheon and Michael Hutcheon, Opera: Desire, Disease, Death, Lincoln: University of Nebraska Press, 1996. Pp. xvi + 295 + illus. £38. ISBN 0-8032-2367-6 LINDSAY PRIOR LINDSAY PRIOR University of WalesCardiff Search for other works by this author on: Oxford Academic PubMed Google Scholar Social History of Medicine, Volume 10, Issue 3, December 1997, Pages 487–488, https://doi.org/10.1093/shm/10.3.487 Published: 01 December 1997
Phylogenetic Analysis of the Class Sporozoea (Phylum Apicomplexa Levine, 1970): Evidence for the Independent Evolution of Heteroxenous Life Cycles (1989)

A phylogenetic analysis of representative genera in the class Sporozoea was undertaken using biological and morphological features to infer evolutionary relationships among the widely recognized groups in the class. Gregarines were used as a functional outgroup to the remaining sporozoa (adeleids, eimeriorins, haemosporinids, and piroplasms). The piroplasms were shown to be closely related to the adeleid parasites. Species of Babesia and Theileria were shown not to form a sister group to the haemosporinids as has been frequently suggested. The data indicate that the biologically diverse family Haemogregarinidae should be divided into at least 3 families (Haemogregarinidae Neveu-Lemaire, 1901, containing the genera Haemogregarina and Cyrilia; Karyolysidae Wenyon, 1926, containing the genus Karyolysus; Hepatozoidae Wenyon, 1926, containing the genus Hepatozoon) because the 4 genera currently within the family do not form a monophyletic group. Correlation between parasite phylogeny and taxonomic affinities of their definitive hosts suggests that the definitive hosts of heteroxenous sporozoa are their ancestral hosts. Heteroxenous sporozoan life cycles apparently have evolved independently to adapt to changes in the feeding behaviors of their definitive hosts.
Synthetic penicillins. Heterocyclic analogs of ampicillin. Structure-activity relations (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic penicillins. Heterocyclic analogs of ampicillin. Structure-activity relationsMinoru Hatanaka and Toshiyasu IshimaruCite this: J. Med. Chem. 1973, 16, 9, 978–984Publication Date (Print):September 1, 1973Publication History Published online1 May 2002Published inissue 1 September 1973https://pubs.acs.org/doi/10.1021/jm00267a005https://doi.org/10.1021/jm00267a005research-articleACS PublicationsRequest reuse permissionsArticle Views630Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimal Truncation of Defibrillation Pulses (1995)

The statement that the optimal pulse for defibrillation has not yet been discovered implies that an ideal pulse exists, but that it is different in shape, duration, and energy as compared to pulses of today. The optimum pulse is that which can defibrillate with lowest energy. Reduction of energy can be reached twofold: by looking for a pulse duration with lowest energy threshold, and by finding the optimal truncation with lowest refibrillating effect. Assuming that there is also a rheobase in defibrillation below which no defibrillating but probably a refibrillating effect exists, the exponential pulse should be truncated if it intersects with the rheobase. Combining the fundamental law of electrostimulation with this boundary condition allows for the mathematical solution of the above problem of optimal energy. Defibrillation can be optimized with respect to pulse duration or tilt and to energy efficiency. The most important parameter in determining other optimized parameters such as output capacitor is the chronaxie. The calculations reveal that the "concept of constant energy" does not accurately describe defibrillation, that today's implantable cardioverter defibrillator devices possess refibrillating tilts, that pulse durations should be programmed to values between 4 and 10 msec, and that smaller output capacitors around 30 microF would minimize the energy requirements. Whether optimized monophasic pulses are inferior or equal to biphasic pulses needs further experimental studies.
Sequence-Controlled Polymers by Ruthenium-Mediated Ring-Opening Metathesis Polymerization (2014)

In sequence-controlled polymers, repeat units of different chemical composition are arranged in a well-defined order. Due to its living characteristics and functional group tolerance, ruthenium-mediated ring-opening metathesis polymerization (ROMP) is a powerful strategy for sequence control. Catalysts for ROMP can be tuned to achieve polymers with highly controlled sequences, thereby encoding structural information in the structure of the catalyst itself. The study of sequence-cotrolled polymerization offers both mechanistic insights and routes to new materials with precise structure–property relationships. This chapter will review design strategies for ruthenium-mediated sequence-controlled ROMP. Structural control in terms of cis/trans-selectivity and tacticity will first be discussed to illustrate the key principles of catalyst design. This framework will then be extended to sequence control for alternating copolymerization, with the goal of motivating continued progress in this area.
100 Gbit/s optical communication systems (1996)

Summary form only given. Recent developments in high-speed optical technology made it possible to experimentally transmit time-division multiplexed (TDM) optical signals at 100-Gbit/s region by generation of picosecond transform-limited optical pulses from a tunable actively mode-locked (ML) erbium-doped fiber (EDF) ring laser.
Radio Access Network Architecture (2007)

This chapter contains sections titled: System Architecture UTRAN Architecture General Protocol Model for UTRAN Terrestrial Interfaces Iu, the UTRAN–CN Interface UTRAN Internal Interfaces UTRAN Enhancements and Evolution UMTS CN Architecture and Evolution References
Multimodal treatment strategies combining neoadjuvant hormonal therapy and/or chemotherapy with radical prostatectomy in high-risk localised prostate cancer (2004)

By combining the readily available clinical parameters of tumour stage, Gleason score of the diagnostic biopsy specimen and serum prostate-specific antigen level, men with newly diagnosed prostate cancer can be assessed as to their risk of treatment failure after radiotherapy or radical prostatectomy. For men considered to be at high-risk of treatment failure after local therapy alone, multimodal treatment strategies may result in improved cancer-control outcomes. This strategy has proven effective in the setting of clinical stage T3 – T4 tumours in which the combination of radiotherapy followed by hormonal therapy has improved patient survival. The benefit of neoadjuvant or adjuvant hormonal and/or chemotherapy followed by radical prostatectomy in this setting is unclear but is the subject of ongoing or planned Phase III clinical trials. These studies will help examine the role of multimodal treatment strategies in these high-risk patients.