gebhart/patrepeval huggingface dataset:
Nonischemic ST-Segment Elevation Induced by Negative Inotropic Agents (1999)

The present study investigated whether regional ventricular dyskinesia (ie, systolic bulging) is a direct cause of ST-segment elevation in canine hearts in vivo. Regional ventricular dyskinesia was induced in 33 anesthetized open-chest dogs by injection of negative inotropic agents into the left anterior descending coronary artery (LAD) without disruption of coronary blood flow. Regional myocardial contraction was assessed in terms of the percent systolic shortening (%SS) and percent systolic bulging (%bulging), which were measured using ultrasonic crystals. The ST-segment elevation of the LAD-perfused area was measured with a unipolar electrode. Lidocaine, a sodium channel blocker, nicorandil, a potassium channel opener, propranolol, a beta-adrenergic blocker, or verapamil, a calcium channel blocker, was administered by intracoronary injection during maximal vasodilation induced by adenosine. All drugs induced dose-dependent ST-segment elevation in association with a parallel reduction in %SS and a parallel increase in %bulging. The absence of myocardial ischemia was confirmed by the absence of NADH fluorescence. It was concluded that regional ventricular dyskinesia had an important role in ST-segment elevation not associated with myocardial ischemia.
Field-Flow Fractionation (1983)

Field-flow fractionation (FFF) technology is applicable to the characterization and separation of macromolecules and particulate species over an effective molecular weight range of 103—1018. Separations take place in an open flow channel over which a field is applied perpendicular to the flow. Thermal FFF, one of the FFF subtechniques, has been shown applicable to polystyrene, polyisoprene, polytetrahydrofuran, polymethyl methacrylate, and polyethylene polymers in a variety of solvents by utilizing thermal diffusion in a temperature gradient field applied perpendicular to flow. Other FFF subtechniques use electrical, sedimentation, and cross-flow fields to separate macromolecules according to their electrical charges, masses, and Stokes diameters, respectively. Advantages of FFF include flexibility due to the variety of fields and programming techniques, high resolution, minimal adverse effects due to surface interactions and shear degradation, and ability in many cases to characterize macromolecules by calculation from first principles.
Mechanism of growth stimulation of L1210 cells by 2-mercaptoethanol in vitro. Role of the mixed disulfide of 2-mercaptoethanol and cysteine. (1981)

The mechanism of the growth-promoting action of 2-mercaptoethanol on mouse lymphoma L1210 cells in vitro has been studied. The normal line of L1210 is deficient in its capacity to take up cystine, and this limits the growth of the cells in normal culture media containing cystine. In the presence of 2-mercaptoethanol, the cells obtain a high capacity to utilize cystine in the medium. The reaction of 2-mercaptoethanol with cystine produces a mixed disulfide of 2-mercaptoethanol and cysteine. The mixed disulfide is taken up by the cells mainly via the L system, a transport system for neutral alpha-amino acids such as leucine. The mixed disulfide within the cells is rapidly reduced to produce cystine and 2-mercaptoethanol which escapes rapidly into the medium and reacts with cystine again. With the aid of this cyclic action of 2-mercaptoethanol, the cells are able to utilize cystine constantly.
Monoclonal Antibody LR-1 Recognizes Murine Heat-Stable Antigen, a Marker of Antigen-Presenting Cells and Developing Hematopoietic Cells (1996)

The rat monoclonal antibody LR-1 was initially described to be reactive with an antigen present on murine splenic B lymphocytes. However, flow-cytometric analyses of cells obtained from thymus, bone marrow, spleen, and lymph nodes showed that LR-1 stained approximately 95, 95, 60-70 and 20% of cells present within these tissues in normal DBA/2 mice. The marker recognized by LR-1 was present on peripheral erythrocytes and splenic dendritic cells, and activation with lipopolysaccharide A further increased expression of this antigen by splenic B cells. This particular tissue and cellular distribution was similar to that delineated with monoclonal antibodies reactive with heat-stable antigen (HSA). Duallabelling studies were conducted to compare the reactivity patterns of LR-1 and the HSA-reactive monoclonal antibody J11d and indicated that both antibodies recognized splenocytes bearing B cell (IgM) or erythroid (TER-119, CD71) but not T cell (CD4, CD8) markers. Splenocytes exposed to phosphoinostol-specific phospholipase C showed marked reduction in LR-1 binding, indicating that this antibody recognized a glycosylphosphatidylinositol-anchored cell surface protein, consistent with the known structure of HSA. Mixing of LR-1 with the HSA-specific antibodies J11d or M1/69 provided flow-cytometric profiles indistinguishable from those obtained with either antibody alone. However, LR-1 inhibited M1/69 binding to splenocytes by 83%, while J11d reduced M1/69 binding to these cells by only 18%. This finding suggested that LR-1 and M1/69 recognize identical splenic HSA epitopes, while LR-1 and J11d bind distinct antigenic determinants of spleen HSA. Western blot analysis of splenocyte, thymocyte, bone marrow cell and erythrocyte detergent extracts revealed that LR-1 reacted with glycoforms of HSA of known molecular weights (30-55 kD). Thus, LR-1 recognizes HSA, the murine analogue of human CD24, and will be a useful reagent with which to investigate the role of HSA in the immune response and hematopoiesis.
Assessing the Ability of Computation/Communication Overlap and Communication Progress in Modern Interconnects (2007)

Computation/communication overlap is one of the fundamental techniques in hiding communication latency. Independent progress support in messaging layer, network interface offload capability and application usage of non-blocking communications are believed to increase overlap and yield performance benefits. In this paper, we analyze four MPI implementations on top of three high-speed interconnects (InfiniBand, Myrinet and iWARP Ethernet) in their ability to support overlap and communication progress. The results confirm that the offload ability needs to be supported with communication progress to increase the level of overlap. Our progress engine micro-benchmark results show that in all examined networks transferring small messages makes an acceptable level of progress and overlap. On the other hand, in most cases, transferring large messages does not make progress independently, decreasing the chances of overlap in applications.
Sequential Treatment of Mood and Anxiety Disorders (2005)

The sequential treatment of mood and anxiety disorders does not fall within the realm of maintenance strategies. It is an intensive, 2-stage approach, which is based on the fact that one course of treatment with a specific treatment (whether pharmacotherapy or psychotherapy) is unlikely to entail solution to the complex array of symptoms of patients with mood and anxiety disorders. The sequential model introduces a conceptual shift in current assessment methods.
Caveolae May Enable Albumin to Enter Human Renal Glomerular Endothelial Cells (2015)

Caveolae on human renal glomerular endothelial cells (HRGECs) are increased in glomerular disease and correlate with the degree of albuminuria. To assess the mechanism by which caveolae contribute to albuminuria, we investigated whether albumin enters into HRGECs through caveolae. HRGECs were incubated with Alexa Fluor 488 labeled BSA or transferrin, followed by immunofluorescence localization with antibody to caveolin-1 (Cav-1), the main structural protein of caveolae, or clathrin, the major structural protein of clathrin coated pits, to assess whether BSA colocalized with Cav-1. HRGECs were also incubated with albumin and caveolae disrupting agents, including methyl beta cyclodextrin (MBCD) and nystatin, to determine whether disrupting caveolae interfered with albumin endocytosis into HRGECs. HRGECs were also incubated with albumin after transfection with Cav-1 small interfering RNAs (siRNAs). Labeled BSA colocalized with Cav-1, but not with clathrin. In contrast, labeled transferrin colocalized with clathrin, but not with Cav-1. Incubation of HRGECs with MBCD or nystatin, or transfection with Cav-1 siRNA, significantly reduced the intracellular amounts of albumin and Cav-1, relative to normal HRGECs, as shown by western blotting and immunofluorescence. These findings indicate that albumin enters HRGECs through the caveolae, suggesting that caveolae play an important role in the pathogenesis of albuminuria by providing a pathway through which albumin can enter glomerular endothelial cells.
Analysis of factors influencing the long‐term effect of treatment of TMJ‐pain dysfunction (1984)

A follow-up study on 154 females was performed approximately 7 years after the start of treatment for TMJ pain dysfunction. At the follow-up the function of the patients' masticatory system had on average greatly improved. The individual variation was great, however. In this paper the influence of such factors as diagnosis, age, general health, occlusal disharmonies, dentition and social environment on the long-term effect of treatment was analysed. Patients with TMJ osteoarthrosis had, on average, no more signs or symptoms of dysfunction at the follow-up than those judged to have had mainly neuromuscular problems. Poor general health was found to have a negative influence both on the immediate response to treatment of TMJ pain dysfunction and on the long-term prognosis. Few correlations were found between occlusal factors and dysfunction. Occlusal interferences showed no correlation to dysfunction at the first examination and at the follow-up were mainly correlated to some reported symptoms. Loss of molars and premolars was correlated to impaired TMJ-function. The patients with repeated periods of treatment (14%) did not differ from the rest with respect to signs and symptoms of dysfunction at the follow-up. In eight patients with extremely long periods of treatment general health problems and/or psychosocial factors were evident.
A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 incombination with carboplatin administered intravenously for the treatment ofrecurrent malignant glioma (2003)

RMP-7, a bradykinin analog, temporarily increases the permeability of the blood-brain tumor barrier to chemotherapy drugs like carboplatin. We conducted a randomized, controlled trial of carboplatin and RMP-7 versus carboplatin and placebo in patients with recurrent malignant glioma. The primary outcome measure was time to tumor progression (TTP). Adults with recurrent glioblastoma multiforme or anaplastic glioma were randomized in a 1:1 ratio to receive carboplatin and either RMP-7 or placebo. Radiation therapy had failed in all patients, and they may have received prior chemotherapy. Carboplatin (dosed to achieve an area under the curve of 5 mg/ml x time for patients who had received prior chemotherapy, or 7 mg/ml x time for those who had not) was given intravenously every 4 weeks, followed by intravenous infusion of either RMP-7 or placebo (300 ng/kg). TTP, tumor response, neuropsychological assessments, functional independence, and quality of life assessments were analyzed every 4 weeks. There were 122 patients enrolled, 62 in the RMP-7 and carboplatin group and 60 in the placebo and carboplatin group. Median TTP was 9.7 weeks (95% CI, 8.3-12.6 weeks) for the RMP-7 and carboplatin group and 8.0 weeks (95% CI, 7.4-12.6 weeks) for the placebo and carboplatin group. Median survival times were 26.9 weeks (95% CI, 21.3-37.6 weeks) for the RMP-7 group and 19.9 weeks (95% CI, 15.0-31.3 weeks) for the placebo group. No differences were noted for time to worsening of neuropsychological assessments, functional independence, or quality of life assessments. The use of RMP-7 had no effect on the pharmacokinetics or toxicity of carboplatin. At the dose and schedule used in this trial, RMP-7 did not improve the efficacy of carboplatin. Recent preclinical pharmacokinetic modeling of RMP-7 suggests that higher doses of RMP-7 may be required to increase carboplatin delivery to tumor.
The influence of excess alkalis on the viscosity of a haplogranitic melt (1995)

Other| April 01, 1995 The influence of excess alkalis on the viscosity of a haplogranitic melt K. U. Hess; K. U. Hess Universitaet Bayreuth, Bayerisches Geoinstitut, Bayreuth, Federal Republic of Germany Search for other works by this author on: GSW Google Scholar D. B. Dingwell; D. B. Dingwell Search for other works by this author on: GSW Google Scholar S. L. Webb S. L. Webb Search for other works by this author on: GSW Google Scholar American Mineralogist (1995) 80 (3-4): 297–304. https://doi.org/10.2138/am-1995-3-411 Article history first online: 02 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Search Site Citation K. U. Hess, D. B. Dingwell, S. L. Webb; The influence of excess alkalis on the viscosity of a haplogranitic melt. American Mineralogist 1995;; 80 (3-4): 297–304. doi: https://doi.org/10.2138/am-1995-3-411 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyAmerican Mineralogist Search Advanced Search Abstract The effect of the addition of 5, 10, and 20 wt% of the alkali oxides on the viscosity of a haplogranitic melt composition has been investigated at 1 atm and in the temperature range of 400–1650 °C. The high-temperature viscosity data were obtained with concentric cylinder viscometry and the low-temperature viscosity data using micropenetration vis-cometry. The combined data sets for low- and high-temperature viscosities have been fitted for each composition using the Tamann-Vogel-Fulcher (TVF) equation. The effect of alkali oxide on the viscosity of a haplogranite melt is extreme. The viscosity decreases with added alkali oxide content in a nonlinear fashion. The first few mole percent of alkali oxide added decreases viscosity several orders of magnitude, whereas subsequent addition of alkali oxide has a much smaller effect. The effects of each of the alkalis are broadly similar, implying that the structural role of the alkalis is common to all. In detail however, the viscosity of the strongly peralkaline melts investigated here increases with the size of the added alkali cation in the order Li <Na <K,Rb,Cs. This trend probably reflects a minor influence of the alkali-O bond strengths on the melt viscosity. This distinction of a dominant depolymerizing influence and a minor alkali specific bond-strength influence has important implications for the comparison of these data with those for the addition of other depolymerizing agents on the viscosity of haplogranitic melt (e.g., H2O, F2O−1). This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Tolvaptan, hyponatremia, and heart failure (2011)

Tolvaptan is the first FDA-approved oral V(2) receptor antagonist for the treatment of euvolemic and hypervolemic hyponatremia, in patients with conditions associated with free water excess such as heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone secretion. Tolvaptan inhibits the binding of arginine vasopressin to the V(2) receptors on the collecting ducts of the kidneys resulting in aquaresis, the electrolytes sparing excretion of water. This article reviews the accumulated experience with tolvaptan and all the major clinical trials that were conducted to study its safety and efficacy and concludes by summarizing clinicians' views of its current application in clinical practice.
Purification and Partial Character of Thermocin YN8674 from Bacillus stearother mophilus YN8674 (2000)

Thermocin YN8674 was partially purified by centrifuge, filtration and gel filtration chromatography. The bacteriocin was stable to heat, pH and was not susceptible to trypsase, cellulase, amylase, rysozyme, ribinuclease. All these showed thermocin YN8674 is not only a stable substance in quality, but also should be a kind of bacteriocin that has special structure.
Pyranocoumarins from Tropical Species of the Genus <i>Calophyllum</i>:  A Chemotaxonomic Study of Extracts in the National Cancer Institute Collection (1998)

(+)-Calanolide A, a novel dipyranocoumarin from the Malesian tree Calophyllum lanigerum var. austrocoriaceum, and a closely related compound, (-)-calanolide B, isolated from Calophyllum teysmannii var. inophylloide, are representatives of a distinct class of nonnucleoside HIV-1 specific reverse-transcriptase inhibitor under development as an AIDS chemotherapeutic. NCI repository specimens totalling 315 organic extracts from 31 taxa of Calophyllum were analyzed for related pyranocoumarins using a simple TLC system. A total of 127 extracts was initially classified as "positive"; eight out of the 31 taxa examined, representing perhaps 28 species already described (1/7-1/8 of all the species in this genus), contained prenylated coumarins, suggesting that these compounds, while sometimes abundantly present, are not widespread in the genus. Representative members of the TLC-positive extracts were partitioned between CH2C12 and 25% aqueous MeOH; the CH2C12-soluble materials were then analyzed by TLC and 1H NMR to confirm the presence of pyranocoumarins. The anti-HIV activity of the partitioned extracts are also presented. This study suggested that there are several distinctive coumarin chemotaxonomic markers distinguishing species of this genus.
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis (2018)

European Centre for Disease Prevention and Control.
Analysis of Vibration and Acoustic Signals for Noncontact Measurement of Engine Rotation Speed (2020)

The non-contact measurement of engine speed can be realized by analyzing engine vibration frequency. However, the vibration signal is distorted by harmonics and noise in the measurement. This paper presents a novel method for the measurement of engine rotation speed by using the cross-correlation of vibration and acoustic signals. This method can enhance the same frequency components in engine vibration and acoustic signal. After cross-correlation processing, the energy centrobaric correction method is applied to estimate the accurate frequency of the engine's vibration. This method can be implemented with a low-cost embedded system estimating the cross-correlation. Test results showed that this method outperformed the traditional vibration-based measurement method.
Design and analysis of a spatial 3-DOF micromanipulator for tele-operation (2002)

In this paper, we propose and develop a spatial 3-DOF tele-micromanipulator for precise position control of micro-objects. Typical feature of this device is a one-module flexure hinge that consists of a revolute joint and a spherical joint. Based on preliminary kinematic analysis and stiffness modeling of the system, optimal design and actuator sizing for the device are performed. Furthermore, FEM analysis and resonant frequency analysis are executed to validate the results of analytic design process. The designed device was successfully implemented to tele-micromanipulation system.
ke ji dang an xin xi zi yuan de shen du kai fa (1995)

科技档案信息资源的深度开发太原钢铁公司档案处殷莉，张林香科技档案信息资源的深度开发是指以科技档案中的知识、信息内容深加工为主的科技档案信息资源开发，是相对于以件、卷、套为单元的开发而言的。后者提供给利用者的是以件、卷、套等为形式的科技档案原件，而科技...
Design and Implementation of Improved Authentication System for Android Smartphone Users (2012)

The devices most often used for IT services are changing from PCs and laptops to smart phones and tablets. These devices need to be small for increased portability. These technologies are convenient, but as the devices start to contain increasing amounts of important personal information, better security is required. Security systems are rapidly being developed, as well as solutions such as remote control systems. However, even with these solutions, major problems could still result after a mobile device is lost. In this thesis, we present our upgraded Lock Screen system, which is able to support authentication for the user's convenience and provide a good security system for smart phones. We also suggest an upgraded authentication system for Android smart phones.
Investigations into the Actions of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1(7–36)amide on Lipoprotein Lipase Activity in Explants of Rat Adipose Tissue (1995)

The direct actions of glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1(7-36)amide and insulin on lipoprotein lipase activity in explants of rat epididymal adipose tissues were investigated. Lipoprotein lipase was extracted into the incubation medium by heparin release of lipoprotein lipase and measured by fatty acid release from a glyceroltriolein emulsion. Insulin and glucose-dependent insulinotropic polypeptide caused a significant stimulation of lipoprotein lipase activity over a dose range of 0.25-4 nmol/L and 4-8 nmol/L, respectively. Explants incubated in the presence of both insulin and glucose-dependent insulinotropic polypeptide (at 0.5 and 4 nmol/L, respectively) showed levels of lipoprotein lipase activity significantly greater than that seen with either hormone alone. Neither insulin- nor glucose-dependent insulinotropic polypeptide-stimulated lipoprotein lipase was modified by the presence of the antibiotic actinomycin-D in the incubation medium, indicating that these two hormones exert their actions on the pre-existing cellular pool of lipoprotein lipase. Glucagon-like polypeptide-1(7-36)amide, over a dose range of 1-8 nmol/L, did not stimulate lipoprotein lipase activity. This study indicates that glucose-dependent insulinotropic polypeptide, in addition to stimulating insulin secretion, has a direct biological action on adipose tissue and in vivo, together with insulin, may promote lipoprotein lipase activity postprandially.
Improving Multimode Interference Couplers Performance Through Index Profile Engineering (2009)

In this paper, a new technique is developed to improve high index contrast multimode interference (MMI) coupler performance. The technique is based on removing modal phase errors by introducing a perturbation in the lateral refractive index of the MMI section. Simulation results for several MMI devices show that this technique is able to provide extremely low excess losses and imbalance for all situations.