gebhart/patrepeval huggingface dataset:
Smyd3 Is Required for the Development of Cardiac and Skeletal Muscle in Zebrafish (2011)

Modifications of histone tails are involved in the regulation of a wide range of biological processes including cell cycle, cell survival, cell division, and cell differentiation. Among the modifications, histone methylation plays a critical role in cardiac and skeletal muscle differentiation. In our earlier studies, we found that SMYD3 has methyltransferase activity to histone H3 lysine 4, and that its up-regulation is involved in the tumorigenesis of human colon, liver, and breast. To clarify the role of Smyd3 in development, we have studied its expression patterns in zebrafish embryos and the effect of its suppression on development using Smyd3-specific antisense morpholino-oligonucleotides. We here show that transcripts of smyd3 were expressed in zebrafish embryos at all developmental stages examined and that knockdown of smyd3 in embryos resulted in pericardial edema and defects in the trunk structure. In addition, these phenotypes were associated with abnormal expression of three heart-chamber markers including cmlc2, amhc and vmhc, and abnormal expression of myogenic regulatory factors including myod and myog. These data suggest that Smyd3 plays an important role in the development of heart and skeletal muscle.
[Clinical significance of levels of lung surfactant protein A in serum, in various lung diseases]. (1995)

To assess the utility of measuring lung surfactant protein A (SP-A) in serum, a newly developed SP-A kit (Teijin TDR-30) was used at four facilities to measure serum SP-A levels in patients with various lung diseases. Serum SP-A levels in healthy volunteers were 24.6 +/- 9.6 ng/ml (mean +/- SD). serum SP-A levels did not differ significantly between different age groups (thirties through seventies). A cut-off level of 43.8 ng/ml was calculated, based on the values of the healthy volunteers. The serum SP-A levels in patients with idiopathic interstitial pneumonia (IIP: 67.9 +/- 42.5 ng/ml), pulmonary alveolar proteinosis (PAP: 7.0 +/- 45.7 ng/ml), and collagen disease with interstitial pneumonia (CDIP: 55.3 +/- 37.9 ng/ml) were significantly higher than those in healthy volunteers. When calculated with the cut-off value stated above, the positive rate of diagnosis for IIP was 71.4%. SP-A levels correlated closely with the clinical course; SP-A levels rose significantly during exacerbations of IIP. Measurement of SP-A in serum is useful for the diagnosis of IIP, PAP, and CDIP, and for monitoring exacerbations of IIP.
Stimulus‐dependent release of tissue‐regenerating factors by equine platelets (2011)

Supernatants collected from coagulated platelets could be an alternative treatment to PRP.
Intrathecal Ziconotide in the Treatment of Refractory Pain in Patients With Cancer or AIDS (2004)

Intrathecal ziconotide provided clinically and statistically significant analgesia in patients with pain from cancer or AIDS.
Design for Testability—A Survey (1982)

This paper discusses the basics of design for testability. A short review of testing is given along with some reasons why one should test. The different techniques of design for testability are discussed in detail. These include techniques which can be applied to today's technologies and techniques which have been recently introduced and will soon appear in new designs.
Non-sequential structure from motion (2011)

Prior work on multi-view structure from motion is dominated by sequential approaches starting from a single two-view reconstruction, then adding new images one by one. In contrast, we propose a non-sequential methodology based on rotational consistency and robust estimation using convex optimization. The resulting system is more robust with respect to (i) unreliable two-view estimations caused by short baselines, (ii) repetitive scenes with locally consistent structures that are not consistent with the global geometry and (iii) loop closing as errors are not propagated in a sequential manner. Both theoretical justifications and experimental comparisons are given to support these claims.
Augmented reality for 3D TV using depth camera input (2010)

This paper presents a capture system based on a depth camera that is used for an augmented reality application. Most of depth cameras are unable to capture the color information corresponding to the same viewpoint. A color is then added besides the depth camera and we applied a transformation algorithm to match the depth map with the color camera's viewpoint. Then, using a depth image based rendering (DIBR) approaches, it becomes possible to synthesize new virtual views from the 2D-plus-depth data. We also address some research issues in the generation of the virtual view is to deal with the newly exposed areas, appearing as holes and denoted as occlusions, which may be revealed in each warped image. The color image and its corresponding enhanced depth image are then combined to produce a mesh representing the real scene. It is used to easily integrate virtual objects in the real scene. Finally, the result can be rendered to create the input image required by a auto-stereoscopic screen.
Isolation of Pseudorabies Virus from Trigeminal Ganglia of a Latently Infected Sow (1980)

A 2-year-old sow with a relatively low virus-neutralization (VN) titer (1:8) against pseudorabies virus (PRV) was brought to the National Animal Disease Center for observation and study. The sow was kept in isolation for approximately 6 weeks, and repeated nasal and tonsillar swabs for virus isolation and blood samples for VN tests were obtained during this interval. At the end of 5 weeks' observation, the sow was injected IM with 200 mg of dexamethasone and was euthanatized 1 week later. Parts of the two trigeminal ganglia, tonsillar tissue, and nasal secretions were cultured in porcine kidney cells. The rest of the trigeminal ganglia was extracted with phenol and tested for presence of the PRV-DNA genome by hybridization with tritiated complementary RNA. The PRV was isolated from the trigeminal ganglia only, and the PRV genome was demonstrated in the same tissue. This latently infected sow was a potential shedder of PRV.
Automated Concurrent Design Based on Combined Feature, Tolerance, Production Process and Cost Models (1993)

Abstract This paper presents a method for conducting automated concurrent design using combined feature, tolerance, production process and cost models. The introduced features are defined and examined in terms of design function, manufacturing method, and geometric shape and accuracy. The integrated design model has three functions: (a) facilitating the generation of all feasible designs by design feature-based knowledge reasoning using an intelligent CAD system; (b) representing various design information using the geometric primitives of a conventional CAD system; (c) describing a design using production process-oriented manufacturing features for evaluating manufacturability and production costs. This approach can incorporate manufacturing consideration into design phase and identify a cost-effective design satisfying given design functions and achieving minimum production costs. Functions of a prototype system are illustrated using an example.
Moment based CNR estimators for BOC/BPSK modulated signal for Galileo/GPS (2008)

Estimation of the Carrier to Noise Ratio (CNR) is one of the most important functionalities of the GPS/Galileo receivers. However, the conventional GPS receivers are not able to satisfy the CNR estimation requirements for the location based services, E-911, and moderate indoor reception. In this paper we derive a total of seven moment based CNR estimators and present the results for the simulation based BOC (Binary Offset carrier) modulated signal and the measurement based BPSK (Binary Phase Shift Keying) modulated signal. We compare the results of the different estimators and find the most robust estimator.
Antimicrobial activity of ropivacaine and other local anaesthetics (2001)

Background and objective It is claimed that local anaesthetics have antimicrobial properties. Our aim was to investigate the antimicrobial effects of different concentrations of ropivacaine, bupivacaine, lidocaine and prilocaine on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. Methods All local anaesthetic dilutions were exposed to microorganisms for 0, 30, 60, 120, 240 min at room temperature. The inoculums taken from diluted suspensions were reinoculated on blood agar and incubated for 18–24 h at 35°C and then the colonies were counted. Results Ropivacaine did not inhibit any of the microorganisms tested. Bupivacaine reduced the viable cells of P. aeruginosa at 0.5% and 0.25% solutions. Lidocaine 5% and 2% and prilocaine 2.0% dilutions reduced the viable cells of all microorganisms tested. Prilocaine 1.0% reduced the viable cells of E. coli, S. aureus and P. aeruginosa. Lidocaine 1% reduced only the viable cells of P. aeruginosa and prilocaine 0.5% reduced only E. coli. Conclusion Ropivacaine had no antimicrobial effect on microorganisms tested. Bupivacaine showed poor antimicrobial effectiveness. Lidocaine and prilocaine had more powerful antimicrobial effects than the other two local anaesthetics.
Inhibition of Autoxidation by Di-μ-thio-dithio-bis (dialkyldithiocarbamate) Dimolybdenum (1974)

The effectiveness of molybdenum dialkyldithiocarbamates (I) and di-μ-thio-dithio-bis (dialkyldithiocarbamates) dimolybdenum (II) as antioxidants in the autoxidation of squalane was investigated and compared with zinc dialkyldithiocarbamate. Induction periods of doped squalane were measured using an automatic recording oxygen absorption apparatus.These compounds show efficient inhibition action and give sharply defined induction periods, there being an abrupt change in O2 uptake rate. It has been found that the potency as oxidation inhibitor of molybdenum compound (I) and (II) is the same irrespective of their degree of sulfurization. It seems, therefore, that the alkyl group play an important role in the activity of oxidation inhibition.It has been experimentally found that zinc and molybdenum compounds (I, II) act as peroxide decomposer for tert-butyl hydroperoxide in chroloform solution and squalane hydroperoxide. Seemingly, capacity of molybdenum compounds (I, II) to decompose hydroperoxide is higher than that of zinc dialkyldithiocarbamate. For autoxidation of squalane initiated by azobisisobutyronitrile, the influence of zinc compound on the rate of oxidation is much more pronounced than the molybdenum compounds (I, II).Therefore, it may be concluded that molybdenum compounds (I, II) suppress the autoxidation of squalane by acting as catalytic peroxide decomposer; on the other hand zinc dialkyldithiocarbamate by terminating the propagation of the oxidative chain reaction.
Fault Injection in Virtualized Systems—Challenges and Applications (2014)

We analyze the interaction between system virtualization and fault injection: (i) use of virtualization to facilitate fault injection into non-virtualized systems, and (ii) use of fault injection to evaluate the dependability of virtualized systems. We explore the benefits of using virtualization for fault injection and discuss the challenges of implementing fault injection in virtualized systems along with resolutions to those challenges. For experimental evaluation, we use a test platform that consists of the Gigan fault injector, that we have developed, with the Xen virtual machine monitor. We evaluate the degree to which fault injection results obtained from running the target system in a virtual machine are comparable to running the target system on bare hardware. We compare results when injection is done from within the target system versus from the hosting hypervisor. We evaluate the performance benefits of leveraging system virtualization for fault injection. Finally, we demonstrate the capabilities of our injector and highlight the benefits of leveraging system virtualization for fault injection by describing deployments of Gigan to evaluate both non-virtualized and virtualized systems.
Sequence and expression of the rat prodynorphin gene. (1985)

We report here the isolation of a lambda genomic clone that contains the nucleotide sequence coding for the main exon of the rat prodynorphin (proenkephalin B) gene. This exon codes for the majority of the translated region of prodynorphin mRNA including the opioid peptides alpha-neo-endorphin, dynorphin A, and dynorphin B. The entire 3' untranslated region is also contained on the lambda clone. Nucleotide sequence comparison with the main exon of the human prodynorphin gene reveals both structural and sequence homology. RNA blot analysis reveals that prodynorphin transcripts can be seen in numerous regions of the rat brain and in the adrenal gland, spinal cord, testis, and anterior pituitary.
Detection of extracellular bound proteinase in EPS-producing lactic acid bacteria cultures on skim milk agar (2001)

These data are useful to validate the relationship between extracellular proteinase and the EPS size of LAB. Also, a convenient medium to detect the presence of extracellular cell-bound proteinase of LAB is valuable for dairy industries.
Unsupervised pattern mining from symbolic temporal data (2007)

We present a unifying view of temporal concepts and data models in order to categorize existing approaches for unsupervised pattern mining from symbolic temporal data. In particular we distinguish time point-based methods and interval-based methods as well as univariate and multivariate methods. The mining paradigms and the robustness of many proposed approaches are compared to aid the selection of the appropriate method for a given problem. For time points, sequential pattern mining algorithms can be used to express equality and order of time points with gaps in multivariate data. For univariate data and limited gaps suffix tree methods are more efficient. Recently, efficient algorithms have been proposed to mine the more general concept of partial order from time points. For time interval data with precise start and end points the relations of Allen can be used to formulate patterns. The recently proposed Time Series Knowledge Representation is more robust on noisy data and offers an alternative semantic that avoids ambiguity and is more expressive. For both pattern languages efficient mining algorithms have been proposed.
On Probability as a Basis for Action (1975)

Abstract The aim of the author is improvement of statistical practice. The author distinguishes between enumerative studies and analytic studies. An enumerative study has for its aim an estimate of the number of units of a frame that belong to a specified class. An analytic study has for its aim a basis for action on the cause-system or the process, in order to improve product of the future. A fair price to pay for an inventory is an example of an enumerative study. Tests of varieties of wheat, insecticides, drugs, manufacturing processes, are examples of analytic studies: the choice of variety or treatment will affect the future out-turn of wheat, future patients, future product. Techniques and methods of inference that are applicable to enumerative studies lead to faulty design and faulty inference for analytic problems. It is possible, in an enumerative problem, to reduce errors of sampling to any specified level. In contrast, in an analytic problem, it is impossible to compute the risk of making a wrong decision. The author provides a number of examples, and pleads for greater care in the writing and teaching of statistical theory and inference.
A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein (1998)

Most mutations in the sequence of the RNA hairpin that specifically binds MS2 coat protein either reduce the binding affinity or have no effect. However, one RNA mutation, a uracil to cytosine change in the loop, has the unusual property of increasing the binding affinity to the protein by nearly 100-fold. Guided by the structure of the protein-RNA complex, we used a series of protein mutations and RNA modifications to evaluate the thermodynamic basis for the improved affinity: The tight binding of the cytosine mutation is due to (i) the amino group of the cytosine residue making an intra-RNA hydrogen bond that increases the propensity of the free RNA to adopt the structure seen in the complex and (ii) the increased affinity of hydrogen bonds between the protein and a phosphate two bases away from the cytosine residue. The data are in good agreement with a recent comparison of the cocrystal structures of the two complexes, where small differences in the two structures are seen at the thermodynamically important sites.
Mixed Magnetism for Refrigeration and Energy Conversion (2011)

Abstract The efficient coupling between lattice degrees of freedom and spin degrees of freedom in magnetic materials can be used for refrigeration and energy conversion. This coupling is enhanced in materials exhibiting the giant magnetocaloric effect. First principle electronic structure calculations on hexagonal MnFe(P, Si) reveal a new form of magnetism: the coexistence of strong and weak magnetism in alternate atomic layers. The weak magnetism of Fe layers (disappearance of local magnetic moments at the Curie temperature) is responsible for a strong coupling with the crystal lattice while the strong magnetism in adjacent Mn‐layers ensures Curie temperatures high enough to enable operation at and above room temperature. Varying the composition on these magnetic sublattices gives a handle to tune the working temperature and to achieve a strong reduction of the undesired thermal hysteresis. In this way we design novel materials based on abundantly available elements with properties matched to the requirements of an efficient refrigeration or energy‐conversion cycle.
Jen1p: A High Affinity Selenite Transporter in Yeast (2010)

Selenium is a micronutrient in most eukaryotes, including humans, which is well known for having an extremely thin border between beneficial and toxic concentrations. Soluble tetravalent selenite is the predominant environmental form and also the form that is applied in the treatment of human diseases. To acquire this nutrient from low environmental concentrations as well as to avoid toxicity, a well-controlled transport system is required. Here we report that Jen1p, a proton-coupled monocarboxylate transporter in S. cerevisiae, catalyzes high-affinity uptake of selenite. Disruption of JEN1 resulted in selenite resistance, and overexpression resulted in selenite hypersensitivity. Transport assay showed that overexpression of Jen1p enables selenite accumulation in yeast compared with a JEN1 knock out strain, indicating the Jen1p transporter facilitates selenite accumulation inside cells. Selenite uptake by Jen1p had a Km of 0.91 mM, which is comparable to the Km for lactate. Jen1p transported selenite in a proton-dependent manner which resembles the transport mechanism for lactate. In addition, selenite and lactate can inhibit the transport of each other competitively. Therefore, we postulate selenite is a molecular mimic of monocarboxylates which allows selenite to be transported by Jen1p.
CCXL.—The nature of the alternating effect in carbon chains. Part III. A comparative study of the directive efficiencies of oxygen and nitrogen atoms in aromatic substitution (1925)

E. L. Holmes and C. K. Ingold, J. Chem. Soc., Trans., 1925, 127, 1800 DOI: 10.1039/CT9252701800
Electron dynamics in topological insulator based semiconductor-metal interfaces (topological p-n interface based on Bi2Se3 class) (2011)

Single-Dirac-cone topological insulators (TI) are the first experimentally discovered class of three dimensional topologically ordered electronic systems, and feature robust, massless spin-helical conducting surface states that appear at any interface between a topological insulator and normal matter that lacks the topological insulator ordering. This topologically defined surface environment has been theoretically identified as a promising platform for observing a wide range of new physical phenomena, and possesses ideal properties for advanced electronics such as spin-polarized conductivity and suppressed scattering. A key missing step in enabling these applications is to understand how topologically ordered electrons respond to the interfaces and surface structures that constitute a device. Here we explore this question by using the surface deposition of cathode (Cu/In/Fe) and anode materials (NO$_2$) and control of bulk doping in Bi$_2$Se$_3$ from P-type to N-type charge transport regimes to generate a range of topological insulator interface scenarios that are fundamental to device development. The interplay of conventional semiconductor junction physics and three dimensional topological electronic order is observed to generate novel junction behaviors that go beyond the doped-insulator paradigm of conventional semiconductor devices and greatly alter the known spin-orbit interface phenomenon of Rashba splitting. Our measurements for the first time reveal new classes of diode-like configurations that can create a gap in the interface electron density near a topological Dirac point and systematically modify the topological surface state Dirac velocity, allowing far reaching control of spin-textured helical Dirac electrons inside the interface and creating advantages for TI superconductors as a Majorana fermion platform over spin-orbit semiconductors.
995. Chemistry related to borazole. Part II. The reaction of secondary amines with boron trichloride (1960)

W. Gerrard, H. R. Hudson and E. F. Mooney, J. Chem. Soc., 1960, 5168 DOI: 10.1039/JR9600005168
Bruden: Om det at stå brud på tværs af generationer (2018)

Bruden står med sit lange slør i Marit Benthe Norheims mo- bile rum-skulptur og favner et erotisk par. Budskabet er klart; erotikken er tilladt i ægteskabet. Med en assemblage af frag- menter fra mit eget bryllup søger jeg her at favne et fortidigt erotisk møde, som lå uden for ægteskabets rammer, og hvor- fra ingen bryllups-assemblage kan samles.
Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment (2003)

WSX-1 is a member of the class I cytokine receptor family with homology to IL-12R beta 2 and is essential for the initial mounting of Th1 responses. STAT1 interacts with tyrosine-phosphorylated WSX-1, and the conserved tyrosine residue of the cytoplasmic domain of WSX-1 is essential for transcriptional activation of STAT1. IL-27 stimulation induced STAT1 phosphorylation in wild-type but not in WSX-1-deficient naive CD4(+) T cells. Although IL-27 did not directly induce IFN-gamma production by wild-type CD4(+) T cells, IL-12-dependent IFN-gamma production was augmented by IL-27 stimulation in wild-type naive CD4(+) T cells but was impaired in WSX-1-deficient naive CD4(+) T cells. Additionally, IL-27 stimulation induced T-bet and IL-12R beta 2 expression in wild-type, but not in WSX-1-deficient, CD4(+) T cells. Thus, during the initiation of Th1 differentiation, the IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system.
Content-based retrieval of video data by the grammar of film (2002)

Image/video data contains numerous information such as objects, image attributes (e.g., color, height, width) of objects, and various semantic contents. Provision of a scheme for the retrieval of video data content is still one of the unfulfilled issues. The authors propose a method of retrieving video data from films by way of specifying the semantic content of scenes. Related to the creation of films, there is a so-called "the grammar of film", which is an accumulation of knowledge and rules for expressing certain semantics of a scene more effectively. They concentrate on the features of video that can be observed as a consequence of the effects of the grammar of film. Since the features relate to shot length, the degree of image dynamics of shots, or the combination of similar shots, this method is less time-consuming than other ways of evaluating sequences of images in detail.