gebhart/patrepeval huggingface dataset:
Nucleotide sequences of immunoglobulin epsilon genes of chimpanzee and orangutan: DNA molecular clock and hominoid evolution. (1987)

To determine the phylogenetic relationships among hominoids and the dates of their divergence, the complete nucleotide sequences of the constant region of the immunoglobulin epsilon-chain (C epsilon 1) genes from chimpanzee and orangutan have been determined. These sequences were compared with the human epsilon-chain constant-region sequence. A molecular clock (silent molecular clock), measured by the degree of sequence divergence at the synonymous (silent) positions of protein-encoding regions, was introduced for the present study. From the comparison of nucleotide sequences of alpha1-antitrypsin and beta- and delta-globin genes between humans and Old World monkeys, the silent molecular clock was calibrated: the mean evolutionary rate of silent substitution was determined to be 1.56 X 10(-9) substitutions per site per year. Using the silent molecular clock, the mean divergence dates of chimpanzee and orangutan from the human lineage were estimated as 6.4 +/- 2.6 million years and 17.3 +/- 4.5 million years, respectively. It was also shown that the evolutionary rate of primate genes is considerably slower than those of other mammalian genes.
Class I restricted interaction between suppressor and cytolytic cells in the response to minor histocompatibility antigens. (1984)

Inoculation of 10(8) unirradiated, minor H antigen-incompatible spleen cells into recipients leads to a failure of the induction of cytolytic T lymphocytes (CTL) specific for these antigens. In contrast, a strong CTL response against minor H antigens is obtained when the inoculated cells are irradiated or treated with Thy-1-, Lyt-1- or Lyt-2-specific antibody and complement. Thus the failure of CTL induction is probably due to suppression mediated by radiosensitive, Lyt-1+2+ T cells in the immunizing inoculum. We demonstrate here that the inoculated cells must share class I MHC loci with the recipients for the suppression to occur. Thus, the interaction between the suppressor T (Ts) cells and their targets (presumably the CTL precursors) is restricted by class I molecules. A disparity at class II loci between the inoculated cells and the recipients overrides the class I-restricted suppression, possibly through a positive allogeneic effect. The simplest interpretation of the class I restriction of Ts cell-target cell interaction is that the CTL precursors recognize minor H antigens in the context of class I molecules on the surface of the Ts cells themselves.
Analog macromodeling using kernel methods (2003)

In this paper we explore the potential of using a general class of functional representation techniques, kernel-based regression, in the nonlinear model reduction problem. The kernel-based viewpoint provides a convenient computational framework for regression, unifying and extending the previously proposed polynomial and piecewise-linear reduction methods. Furthermore, as many familiar methods for linear system manipulation can be leveraged in a nonlinear context, kernels provide insight into how new, more powerful, nonlinear modeling strategies can be constructed. We present an SVD-like technique for automatic compression of nonlinear models that allows systematic identification of model redundancies and rigorous control of approximation error.
Long‐term survival and cell death of newly generated neurons in the adult rat olfactory bulb (2002)

In the adult rat olfactory bulb, neurons are continually generated from progenitors that reside in the lateral ventricle wall. This study investigates long-term survival and cell death of newly generated cells within the adult olfactory bulb. After injecting rats at 2 months of age with 5-bromodeoxyuridine (BrdU), the newly generated cells were quantified over a period of 19 months. A peak of BrdU-positive cells was reached in the olfactory bulb 1 month after BrdU injection, when all new cells have finished migrating from the ventricle wall. Thereafter, a reduction of BrdU-positive cells to about 50% was observed and it was confirmed by dUTP-nick end-labelling (TUNEL) that progenitors and young neurons undergo programmed cell death. However, cells that survived the first 3 months after BrdU injection persisted for up to 19 months. The majority of the BrdU-positive cells that reach the olfactory bulb differentiate into granule cells, but a small fraction migrate further into the glomerular layer. These newborn cells differentiate more slowly into periglomerular interneurons, with a delay of more than 1 month when compared to the granule cells. The newly generated periglomerular neurons, among them a significant fraction of dopaminergic cells, showed a similar decline in number compared to the granule cell layer and long-term survival for the remaining new neurons of up to 19 months. Rather than replacing old neurons, this data suggests that adult olfactory bulb neurogenesis utilizes the overproduction and turnover of young neurons, which is reminiscent of the cellular dynamics observed during brain development.
Efficient Architectures for Retrieving Mixed Data with Rest Architecture Style and HTML5 Support (2013)

This Thesis is brought to you for free and open access by TopSCHOLAR®. It has been accepted for inclusion in Masters Theses &amp; Specialist Projects by an authorized administrator of TopSCHOLAR®. For more information, please contact connie.foster@wku.edu.
Potent Mitogenic Activity of Staphylococcal Enterotoxin A Requires Induction of Interleukin 2 (1988)

Staphylococcal enterotoxin A (SEA), the most common cause of food poisoning, is capable of stimulating human T lymphocyte proliferation at concentrations as low as 10(-13) to 10(-16) M. SEA also induces the lymphokines interleukin 2 (IL 2) and interferon gamma (IFN gamma) at similarly low concentrations. HPL cultures were stimulated with SEA in the presence of antibodies to IL2 to determine the possible role of this lymphokine in its potent mitogenic effects. Polyclonal and monoclonal antibodies to human IL 2 blocked SEA-induced mitogenesis. Treatment of cultures with higher concentrations of SEA overcame the anti-IL 2 blockage, corresponding to induction of higher concentrations of IL 2. Blockage of HPL mitogenesis by anti-IL 2 antibodies also resulted in inhibition of IFN gamma production, which is dependent on IL 2. Neutralizing monoclonal antibody to IFN gamma failed to block SEA-induced proliferation. The data indicate that the induction of IL 2, but not IFN gamma, is a requirement for SEA induced lymphocyte proliferation. SEA food poisoning and IL 2 therapy for cancer result in similar toxic symptoms, characterized by malaise, fever, nausea or vomiting, and diarrhea. The similarity between SEA and IL2 toxic effects, the fact that SEA is a potent inducer of lymphokines such as IL 2, and the fact that IL 2 induction is a prerequisite for the mitogenic effects of SEA raises the intriguing question of the role of lymphokines such as IL 2 in SEA-induced food poisoning.
Heterogeneous Mercury Reaction Chemistry on Activated Carbon (2011)

Experimental and theory-based investigations have been carried out on the oxidation and adsorption mechanism of mercury (Hg) on brominated activated carbon (AC). Air containing parts per billion concentrations of Hg was passed over a packed-bed reactor with varying sorbent materials at 140 and 30 degrees C. Through X-ray photoelectron spectroscopy surface characterization studies it was found that Hg adsorption is primarily associated with bromine (Br) on the surface, but that it may be possible for surface-bound oxygen (O) to play a role in determining the stability of adsorbed Hg. In addition to surface characterization experiments, the interaction of Hg with brominated AC was studied using plane-wave density functional theory. Various configurations of hydrogen, O, Br, and Hg on the zigzag edge sites of graphene were investigated, and although Hg-Br complexes were found to be stable on the surface, the most stable configurations found were those with Hg adjacent to O. The Hg-carbon (C) bond length ranged from 2.26 to 2.34 A and is approximately 0.1 A shorter when O is a nearest-neighbor atom rather than a next-nearest neighbor, resulting in increased stability of the given configuration and overall tighter Hg-C binding. Through a density of states analysis, Hg was found to gain electron density in the six p-states after adsorption and was found to donate electron density from the five s-states, thereby leading to an oxidized surface-bound Hg complex.
Modern Raman spectroscopy: a practical approach (2005)

Preface. Acknowledgements. CHAPTER 1: INTRODUCTION, BASIC THEORY AND PRINCIPLES. 1.1 Introduction. 1.2 Basic Theory. 1.3 Molecular Vibrations. 1.4 Summary. CHAPTER 2: THE RAMAN EXPERIMENT - RAMAN INSTRUMENTATION, SAMPLE PRESENTATION, DATA HANDLING AND PRACTICAL ASPECTS OF INTERPRETATION. 2.1 Introduction. 2.2 Choice of Instrument. 2.3 Visible Excitation. 2.4 NIR Excitation. 2.5 Raman Sample Preparation and Handling. 2.6 Sample Mounting Accessories. 2.7 Microscopy. 2.8 Calibration. 2.9 Data Handling, Manipulation and Quantitation. 2.10 Approach to Qualitative Interpretation. 2.11 Summary. CHAPTER 3: THE THEORY OF RAMAN SPECTROSCOPY. 3.1 Introduction. 3.2 Absorption and Scattering. 3.3 States of a System and Hooke's Law. 3.4 The Nature of Polarizability and the Measurement of Polarization. 3.5 The Basic Selection Rule. 3.6 Number and Symmetry of Vibrations. 3.7 Symmetry Elements and Point Groups. 3.8 The Mutual Exclusion Rule. 3.9 The Kramer Heisenberg Dirac Expression. 3.10 Lattice Modes. 3.11 Conclusions. CHAPTER 4: RESONANCE RAMAN SCATTERING. 4.1 Introduction. 4.2 Theoretical Aspects. 4.3 Practical Aspects. 4.4 Examples of the Use of Resonance Raman Scattering. 4.5 Conclusions. CHAPTER 5: SURFACE-ENHANCED RAMAN SCATTERING AND SURFACE-ENHANCED RESONANCE RAMAN SCATTERING. 5.1 Introduction. 5.2 Theory. 5.3 Electromagnetic and Charge Transfer Enhancement. 5.4 Selection Rules. 5.5 Applications of SERS. 5.6 Applications of SERRS. 5.7 The Basic Method. CHAPTER 6: APPLICATIONS. 6.1 Introduction. 6.2 Inorganics and Minerals. 6.3 Art and Archaeology. 6.4 Polymers and Emulsions. 6.5 Colour. 6.6 Electronics Applications. 6.7 Biological and Pharmaceutical Applications. 6.8 Forensic Applications. 6.9 Plant Control and Reaction Following. 6.10 Summary. CHAPTER 7: MORE ADVANCED RAMAN SCATTERING TECHNIQUES. 7.1 Flexible Optics. 7.2 Tuneable Lasers, Frequency Doubling and Pulsed Lasers. 7.3 Spatially Resolved Systems. 7.4 Nonlinear Raman Spectroscopy. 7.5 Time Resolved Scattering. 7.6 Raman Optical Activity. 7.7 UV Excitation. 7.8 Conclusions. Index.
Speed Improvements for Dual-Slope A/D Converters (1985)

This article illustrates four techniques applied to the well-known dual-slope analog-to-digital converter (ADC) in order to improve its speed of conversion. These are triple-slope, multislope I, multislope II, and multislope III, respectively. Linear and digital IC's have been used in these techniques. To minimize cost one of the design goals was to devise techniques requiring a minimum of precision parts.
Novel Approach to Cochannel Interference Mitigation Using Wilcoxon Generalized Radial Basis Function Network (2009)

Wireless communication system are affected by intersymbol interference, co-channel interference in the presence of additive white Gaussian noise. Different equalization techniques have been used to mitigate these effects using artificial neural networks based multilayer perceptron network, radial basis function, fuzzy system, functional link artificial neural networks and etc, conventionally linear adaptive filter trained by LMS and RLS algorithm. In this paper we proposed a RBF based equalizer which is trained using Wilcoxon learning method. The equalizer presented shows considerable performance gain. Simulation studies have been conducted to demonstrate the performance of Wilcoxon training for this class of problem.
Source Reconstruction for the ETEX-1 Tracer Release with a Lagrangian Dispersion Model (2001)

Preliminary studies (Seibert, 1997; Seibert, 1999) used simple trajectories to provide a first approximation to the SRM. This approach already yields useful results and can be used instead of more conventional trajectory statistics. However, a real dispersion model (Eulerian or Lagrangian) is needed for an accurate description of the source-receptor matrices. Receptor-oriented Lagrangian models are computationally efficient if the number of receptors (measurements) is less than the number of potential source elements. The usual choice in this case was for a long time the Lagrangian box model. It has the advantage that chemistry can be included, but does not describe transport and dispersion very well (problems related, e.g., to wind shear). As our approach for inversion anyway does not allow for non-linear chemical reactions, a Lagrangian particle dispersion model (LPDM) was an attractive choice as it offers high accuracy though no chemistry is included.
Comparative analysis of antimicrobial activity of leaf extracts from fresh green tea, commercial green tea and black tea on pathogens (2011)

Medicinal plants have been a major source of therapeutic agents for alleviation and cure diseases. In the present investigation comparative analysis of antimicrobial activity of green tea Camellia sinensis fresh leaves, commercial green tea leaves and dust tea against enteropathogens and specific fungi were carried out. The antimicrobial activity of the extracts of Camellia sinensis was analyzed by using well diffusion method paper disk diffusion method and minimum inhibitory concentration. Synergistic activity of green tea and commercial antibiotic chlorophenicol was analyzed. The allopathic antibacterial drugs are said to be costlier and have more side effects. Moreover multiple drug resistant strains are on the raise in this era and thus complicating treatment. On the other hand herbal preparations are comparatively cheaper and have lesser side effects. So, herbal preparations can supplement other systems of medicine for the treatment of diseases caused by bacteria and fungi.
A Faster Algorithm for Reducing the Computational Complexity of Convolutional Neural Networks (2018)

Convolutional neural networks have achieved remarkable improvements in image and video recognition but incur a heavy computational burden. To reduce the computational complexity of a convolutional neural network, this paper proposes an algorithm based on the Winograd minimal filtering algorithm and Strassen algorithm. Theoretical assessments of the proposed algorithm show that it can dramatically reduce computational complexity. Furthermore, the Visual Geometry Group (VGG) network is employed to evaluate the algorithm in practice. The results show that the proposed algorithm can provide the optimal performance by combining the savings of these two algorithms. It saves 75% of the runtime compared with the conventional algorithm.
Minuet: A Scalable Distributed Multiversion B-Tree (2012)

Data management systems have traditionally been designed to support either long-running analytics queries or short-lived transactions, but an increasing number of applications need both. For example, online games, socio-mobile apps, and e-commerce sites need to not only maintain operational state, but also analyze that data quickly to make predictions and recommendations that improve user experience. In this paper, we present Minuet, a distributed, main-memory B-tree that supports both transactions and copy-on-write snapshots for in-situ analytics. Minuet uses main-memory storage to enable low-latency transactional operations as well as analytics queries without compromising transaction performance. In addition to supporting read-only analytics queries on snapshots, Minuet supports writable clones, so that users can create branching versions of the data. This feature can be quite useful, e.g. to support complex "what-if" analysis or to facilitate wide-area replication. Our experiments show that Minuet outperforms a commercial main-memory database in many ways. It scales to hundreds of cores and TBs of memory, and can process hundreds of thousands of B-tree operations per second while executing long-running scans.
Visuo-tactile system for 3D digital models rendering (2015)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
A pulsed high-power quantum well laser using an asymmetric waveguide (1996)

A , strained InGaAs quantum well laser, reaching a record high power of 31 W at 50 A in 230 ns pulsed operation, is reported. The new structure is based on a wide asymmetric multimode optical waveguide that reduces the optical power density on the laser's mirrors, to produce a higher maximum output power. Modal discrimination is obtained by proper positioning of the quantum well.
Audio hallway (1998)

Article Audio hallway: a virtual acoustic environment for browsing Share on Author: Chris Schmandt M.I.T. Media Laboratory M.I.T. Media LaboratoryView Profile Authors Info & Claims UIST '98: Proceedings of the 11th annual ACM symposium on User interface software and technologyNovember 1998 Pages 163–170https://doi.org/10.1145/288392.288597Online:01 November 1998Publication History 27citation674DownloadsMetricsTotal Citations27Total Downloads674Last 12 Months12Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Dynamic testing of post-tensioned rocking walls (2012)

https://nees.org/resources/5092/download/15WCEEFinal.pdf
Collision-avoidance system based on optical flow (2003)

Proposes a collision-avoidance system for vehicles, which warns the driver of impending collision. It is based on the parallel computation of the image-motion velocity vector field over a large part of the image plane. This image-motion field is then used as the input to a neural network which computes two properties of the movement of the vehicle relative to its environment. The first is the direction of heading of the vehicle in terms of azimuth and elevation angles. The second is the time-to-contact with the immediate environment in front of the vehicle given the current velocity of the vehicle. The detection of these two properties could be used to warn the driver of impending collision or could be used to make online adjustments to the current trajectory and path of the vehicle.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Integrated signal conditioning for diaphragm pressure sensors (1979)

A silicon thin-diaphragm piezoresistive pressure sensor incorporating signal conditioning has been developed. The device exhibits 1% accuracy over a wide pressure range, requiring only two leads and no external components.
Combination therapy for patients with Type 2 diabetes: repaglinide in combination with metformin (2010)

In patients with Type 2 diabetes mellitus (T2DM), adequate glycemic control is a critical factor in reducing long-term micro- and macro-vascular complications. Traditionally, the approach is to initiate monotherapy first, followed by combination therapy that targets two main defects in T2DM. Repaglinide, a rapidly acting insulin secretagog, stimulates insulin secretion via closure of ATP-dependent potassium channels on the cell membrane of β-cells. Repaglinide is ideally used at mealtime to reduce postprandial glucose levels, thus lowering the 24-h blood glucose profile and improving HbA1c levels. Metformin is an insulin sensitizer that effectively acts against insulin resistance, one of the predominant metabolic defects in T2DM. A combination of repaglinide and metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with T2DM. When monotherapy with oral antidiabetic agents fails, combination therapy with repaglinide plus metformin has been demonstrated to be safe and effective in the treatment of T2DM.
Accelerating cache coherence mechanism with speculation (2014)

Directory is one of the common method to maintain cache coherence in multi/many-core systems. However, directory has problems in area, latency and complexity of protocol. Conversely, directoryless coherence mechanism, where each core invalidates its own L1 cache block (tear-off copy) is proposed. The problem of this method is that the cache blocks which are not written by another core are invalidated. We accelerate the coherence mechanism by speculatively executing with the value of these invalidated cache blocks. Our results show 2\% acceleration on average over derectory based MOESI protocol in 16 core system.
Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice. (2003)

These data show that administration of IFN-alpha at optimal biological dose and schedule in combination with gemcitabine induced apoptosis in tumor-associated endothelial cells and decreased growth of human pancreatic cancer cells in the pancreas, leading to a significant increase in survival.
An efficient and optimized PCR method with high fidelity for site-directed mutagenesis. (1995)

We have developed an efficient method for site-directed mutagenesis using two subsequential rounds of PCR. In this method, PCR conditions are optimized to favor high fidelity of Taq DNA polymerase in the presence of equimolar concentrations of MgCI2 and dNTP in the reaction mixture (pH 5.5-6.2). This method makes use of a pair of universal primers and the multiple cloning site of pUC/M13 vectors. Only one mutagenic primer is required per target site. In the second round of PCR, the 3' extension of the wild-type DNA strand is blocked by the presence of a segment of nonhomologous sequence at its 3' end, and as a consequence, the amplified, full-length DNA fragment is chiefly from the mutant strand. Furthermore, because the mutated DNA fragment has flanking restriction sites different from those of the wild-type DNA fragment, the wild-type DNA fragment is totally excluded in the step involving selective cloning of the mutant DNA fragment. This method was successfully used to introduce four, nonadjacent mutations in the 5' regulatory region of the cytochrome P450BM-3 gene. All 20 analyzed clones from these four cases of mutagenesis carried the desired mutations, and no undesired mutations were observed. We observed that the larger the number of mismatched nucleotide residues in the mutagenic primer, the higher the concentration of MgCI2 was necessary for successful PCR amplification. Our experimental results indicate that this method offers improvements in efficiency, flexibility, and fidelity.
Isolation, Structure Determination, and Biological Activity of a Novel Alkaloid, Perophoramidine, from the Philippine Ascidian <i>Perophora</i> <i>n</i><i>amei</i> (2002)

Chemical investigation of the Philippine ascidian Perophora namei has resulted in the isolation of a novel polycyclic alkaloid, perophoramidine (1). The structure of 1 was determined by the interpretation of 1D/2D NMR and MS data. Dehalogenation of perophoramidine (1) by ammonium formate catalyzed transfer hydrogenation confirmed the type and number of halogen atoms present in 1.