gebhart/patrepeval huggingface dataset:
LanV, a Bifunctional Enzyme: Aromatase and Ketoreductase during Landomycin A Biosynthesis (2005)

LanV is involved in the biosynthesis of landomycin A. The exact function of this enzyme was elucidated with combinatorial biosynthesis by using Streptomyces fradiae mutants that produce urdamycin A. After expression of lanV in S. fradiae DeltaurdM, which is a mutant that accumulates rabelomycin, urdamycinon B and urdamycin B were found to be produced by the strain. This result indicates that LanV is involved in the 6-ketoreduction of the angucycline core, which preceeds a 5,6-dehydration reaction. 9-C-D-Olivosyltetrangulol was also produced by this strain; this demonstrates that LanV catalyses the aromatization of ring A of the angucycline structure. Coexpression of lanV and lanGT2 in S. fradiae AO, a mutant that lacks all four urdamycin glycosyltransferases, resulted in the production of tetrangulol and the glycoside landomycin H, both of which have an aromatic ring A. As glycosylated angucyclines were not observed after expression of lanGT2 in the absence of lanV, we conclude that LanGT2 needs an aromatized ring A for substrate recognition.
Experimental Evaluation of TENGs for Energy Harvesting in Maritime Applications (2019)

Triboelectric nanogenerators (TENGs) have been recognized as a promising harvesting technology to satisfy the power requirements of some marine activities. Our current work addresses the TENG design for the purpose of energy harvesting in the sea. In this paper we present a prototype currently under development, in which spheres made of a triboelectric material move within a limited volume due to external mechanical excitation. The spheres move along a printed circuit board having several electrodes and a PDMS film deposited on top, producing numerous voltage spikes. Experimental results are provided with time-domain wave forms and power characterization of the TENG.
Reviving Artificial Blood: Meeting the Challenge of Dealing with NO Scavenging by Hemoglobin (2010)

Red cell substitutes: Heme proteins that bind oxygen also bind NO, so designing safe and effective heme-based transfusion alternatives that have low affinities for NO but bind O2 effectively for delivery remains a significant challenge. Here we show that NO scavenging by hemoglobin may be counteracted by the nitrite reductase activity of hemes in modified proteins.
Ultrasound Imaging of the Lumbar Spine in the Transverse Plane: The Correlation Between Estimated and Actual Depth to the Epidural Space in Obese Parturients (2009)

We found a strong correlation between the ultrasound-estimated distance to the epidural space and the actual measured needle distance in obese parturients. We suggest that prepuncture lumbar ultrasound may be a useful guide to facilitate the placement of epidural needles in obese parturients.
Low magnetic field effects on embryonic bone growth. (1991)

Pulsed electromagnetic fields [EMF] and electric fields have been demonstrated to promote osteogenesis and wound healing. Pulsed EMF's have been approved since 1979 by the FDA, and are highly effective in the treatment of non-union fractures. Increased linear growth, cellular proliferation, cAMP and uptake of tritiated thymidine have been documented on short term exposure. Yet the mechanisms and the changes that occur have been difficult to quantify. Fluorescence, light, and electron microscopy were utilized in this study to assess any histological changes in bone. During incubation chick embryos were exposed to magnets oriented in various positions. Controls were oriented similarly using galvanized steel plugs. Field density in the center of the field was measure by a gaussmeter with a transverse probe. Each chick embryo in its magnetic field was isolated from the magnetic fields of others by being encased in a steel box. Intramembranous [calvaria] and endochondral [tibia] ossification were studied. Fluorescent dyes were micropipetted intravascularly at various stages of chick development. The tissues were fixed in methacrylate and stained for histomorphological study.
Interferon alfa treatment for Sjogren's syndrome associated neuropathy (2005)

Treatment response to interferon alfa (IFNalpha) is described in three consecutive cases of two forms of Sjogren's syndrome associated neuropathy (SSN)-two with sensory ataxic ganglionopathy and one with sensorimotor neuropathy with demyelinating features. All responded well to IFNalpha in terms of neuropathic symptoms, sicca symptoms, antibody titres, and findings in salivary gland biopsy specimens. IFNalpha thus showed promise in treating both SSN and the underlying Sjogren's syndrome.
Simulants of malignant melanoma: a rogue's gallery of melanocytic and nonmelanocytic imposters. (1994)

Although overdiagnosis of malignant melanoma involves no potential loss of life, it affects the patient profoundly and therefore should be addressed conscientiously. This review of both benign and malignant, melanocytic and nonmelanocytic simulants of malignant melanoma emphasizes the pitfalls and repercussions of misdiagnosis. For more accurate differentiation, simulants are classified first as superficial (intraepidermal) or deep (dermal), then as melanocytic or nonmelanocytic.
Spin Pumping and Spin-Transfer Torques in Antiferromagnets (2014)

Spin pumping and spin-transfer torques are two reciprocal phenomena widely studied in ferromagnetic materials. However, pumping from antiferromagnets and its relation to current-induced torques have not been explored. By calculating how electrons scatter off a normal metal-antiferromagnetic interface, we derive pumped spin and staggered spin currents in terms of the staggered field, the magnetization, and their rates of change. For both compensated and uncompensated interfaces, spin pumping is of a similar magnitude as in ferromagnets with a direction controlled by the polarization of the driving microwave. The pumped currents are connected to current-induced torques via Onsager reciprocity relations.
Differential Effects of Nicotine and Smoke Condensate on Bone Cell Metabolic Activity (2005)

The data suggest that nicotine acts as a direct stimulant of bone cell metabolic activity. Smoke condensate containing equivalent levels of nicotine elicits an inhibitory effect. A probable speculation is that the delay in clinical healing of skeletal trauma in smoking patients may in part be a result of absorption of components of smoke other than nicotine.
Optical-fiber passive ring resonator in a low-mode radiation-propagation regime (2000)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. L. Dmitriev, Zhang Yanshen, and Ma Xinyu, "Optical-fiber passive ring resonator in a low-mode radiation-propagation regime," J. Opt. Technol. 67, 219- (2000) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Abstract B37: VSV-GP: A vaccine vector and oncolytic virus (2015)

Abstract Oncolytic viruses have recently shown significant clinical benefits in several cancers. Interestingly, in addition to debulking the tumor by direct oncolysis, they were found to act as a cancer vaccine by setting free tumor antigen in the presence of virus-induced danger signals, which have an adjuvant effect. However, as oncolytic viruses induce neutralizing antibodies that inactivate the virus, oncolytic viruses are not delivered efficiently to cancer tissue upon repeated systemic application. Thus, repeated applications of oncolytic viruses have been restricted to intratumoral injections, which clinically has not been convincingly effective in metastatic disease. We generated the oncolytic virus VSV-GP (Muik et al., Cancer Res, 2014) that is highly potent, lacks toxicity even at high doses (so far tested in mice and rabbits), can be produced at high titers and, above all, does not induce neutralizing antibodies readily. Thus, VSV-GP is unique among the oncolytic viruses in that it can be applied repeatedly without loosing efficacy. VSV-GP is highly effective leading to cure in several cancer mouse models, i.e. malignant glioma, melanoma, prostate cancer and ovarian cancer. In addition to oncolysis, VSV-GP induced a sound anti-tumor immune response and acted synergistically with other cancer immunotherapeutics. Moreover, VSV-GP was shown to be a highly promising vaccine vector and is the only replication competent viral vaccine vector that efficiently boosts the immune response upon repeated application. VSV-GP is thus a highly versatile replication competent viral vector platform for vaccination and cancer therapy. Citation Format: Alexander Muik, Janine Kimpel, Reinhard Tober, Carles Urbiola, Dorothee von Laer. VSV-GP: A vaccine vector and oncolytic virus. [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. Philadelphia (PA): AACR; Cancer Immunol Res 2015;3(10 Suppl):Abstract nr B37.
Dynamics of Cardiac Arrhythmias (1996)

An elderly gentleman with heart disease was admitted to hospital for treatment of an abnormal heart rhythm called ventricular tachycardia. This potentially fatal rhythm can occur days, or even years, after a heart attack. It is associated with an abnormally rapid heartbeat that arises from tissue in the heart attack-damaged portions of the ventricles—the two main pumping chambers of the heart. (See the box on page 41.)
ChemInform Abstract: Asymmetric Acid—Base Bifunctional Catalysis with Organic Molecules (2011)

Abstract Review: 120 refs.
Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice (2014)

Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder that associates with prominent memory and behavioural deficits. Patients' antibodies react with the N-terminal domain of the GluN1 (previously known as NR1) subunit of NMDAR causing in cultured neurons a selective and reversible internalization of cell-surface receptors. These effects and the frequent response to immunotherapy have suggested an antibody-mediated pathogenesis, but to date there is no animal model showing that patients' antibodies cause memory and behavioural deficits. To develop such a model, C57BL6/J mice underwent placement of ventricular catheters connected to osmotic pumps that delivered a continuous infusion of patients' or control cerebrospinal fluid (flow rate 0.25 µl/h, 14 days). During and after the infusion period standardized tests were applied, including tasks to assess memory (novel object recognition in open field and V-maze paradigms), anhedonic behaviours (sucrose preference test), depressive-like behaviours (tail suspension, forced swimming tests), anxiety (black and white, elevated plus maze tests), aggressiveness (resident-intruder test), and locomotor activity (horizontal and vertical). Animals sacrificed at Days 5, 13, 18, 26 and 46 were examined for brain-bound antibodies and the antibody effects on total and synaptic NMDAR clusters and protein concentration using confocal microscopy and immunoblot analysis. These experiments showed that animals infused with patients' cerebrospinal fluid, but not control cerebrospinal fluid, developed progressive memory deficits, and anhedonic and depressive-like behaviours, without affecting other behavioural or locomotor tasks. Memory deficits gradually worsened until Day 18 (4 days after the infusion stopped) and all symptoms resolved over the next week. Accompanying brain tissue studies showed progressive increase of brain-bound human antibodies, predominantly in the hippocampus (maximal on Days 13-18), that after acid extraction and characterization with GluN1-expressing human embryonic kidney cells were confirmed to be against the NMDAR. Confocal microscopy and immunoblot analysis of the hippocampus showed progressive decrease of the density of total and synaptic NMDAR clusters and total NMDAR protein concentration (maximal on Day 18), without affecting the post-synaptic density protein 95 (PSD95) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. These effects occurred in parallel with memory and other behavioural deficits and gradually improved after Day 18, with reversibility of symptoms accompanied by a decrease of brain-bound antibodies and restoration of NMDAR levels. Overall, these findings establish a link between memory and behavioural deficits and antibody-mediated reduction of NMDAR, provide the biological basis by which removal of antibodies and antibody-producing cells improve neurological function, and offer a model for testing experimental therapies in this and similar disorders.
Effect of Sieve Size for wet and Dry Screening on the Physical Properties of Lactose Granules and Their Corresponding Tablets (1983)

Various batches of lactose granules were prepared by wet granulation process using acacia, cassava starch and polyvinylpyrrolidone separately as binders by inter-changing sieves for wet and dry screening, The effects of wet and dry screen aperture sizes together with the effects of the binders used on the physical properties of such granules and the corresponding tablets were investigated. The bulk volume of granules was found to be increased as the aperture size of sieves for dry screening increased while keeping a particular sieve constant for wet screening. No significant difference was observed with regards to the effect of sieve size upon the flow rate.It was also observed that keeping the sieve size for wet screening constant, the mean tablet weight increased while the tablet weight variation decreased as the sieve size for dry screening decreased. There found to be an observable relationship between the sieve sizes used for dry and wet screening, average granule size and hardness of tablets. When a particular sieve was kept constant for wet screening, an increase in the sieve aperture size for dry screening resulted in an increase in average granule size and a decrease in tablet hardness. This may be due to increase in void space, decrease in die fill and less bonding between the granules. The disintegration time of the tablets was found to be significantly influenced by the sieve size combination used for wet and dry screening. When sieves for wet screening were kept constant, an increase in the sieve size for dry screening generally produced tablets of lower disintegration time.
Modifications of Substituted Seryl and Threonyl Residues in Phospopeptides and a Polysialoglycoprotein by β-Elimination and Nucleophile Additions1 (1990)

The beta-elimination and nucleophile addition reactions of the substituted serine and threonine residues were studied using several synthesized fluorescence-labeled phosphopeptides and a salmon egg polysialoglycoprotein (PSGP). The reagents used were 1 M CH3SH-0.43 M NaOH, 1 M NaBH4-0.1 M NaOH, 1 M CH3NH2-0.1 M NaOH, and 1 M Na2SO3-0.1 M NaOH. The beta-elimination reaction of a phosphoserine peptide, Gly-Ser(PO4)-Glu-AEAP, was about 20 times faster than that of the corresponding phosphothreonine peptide. The carboxyl-side amino acid of the phosphoamino acids in peptides greatly affected the beta-elimination rate. The beta-elimination reaction rates of O-glycosyl serine and threonine in the polysialoglycoprotein were similar and were about a half of that of the phosphoserine peptide. The rates of addition of the three nucleophiles and hydrogen to alpha-aminoacrylic acid (beta-elimination product of substituted serine) in the peptide decreased in the order of CH3SH, Na2SO3, CH3NH2, and H2(NaBH4), and the addition to alpha-aminocrotonic acid (beta-elimination product of substituted threonine) in the order of Na2SO3, CH3NH2, CH3SH, and H2. These results indicated that sulfite is the most recommended nucleophile because of its high addition rate. If sulfite addition is carried out in the presence of NaBH4, sugar chains can be released as alditols, converting the sugar-attaching amino acids to beta-sulfoamino acids.
Method of determination of initiator efficiency: application to UV polymerizations using 2,2-dimethoxy-2-phenylacetophenone (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethod of determination of initiator efficiency: application to UV polymerizations using 2,2-dimethoxy-2-phenylacetophenoneDevdatt L. Kurdikar and Nikolaos A. PeppasCite this: Macromolecules 1994, 27, 3, 733–738Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ma00081a017https://doi.org/10.1021/ma00081a017research-articleACS PublicationsRequest reuse permissionsArticle Views2139Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
APPLICATION OF THERMAL METHODS OF ANALYSIS TO ORGANIC COATINGS AND RELATED MATERIALS (1969)

THE USE OF THERMAL ANALYSIS AND ITS SIGNIFICANCE IN SOLVING PROBLEMS INVOLVING COATINGS AND RESINS IS DEMONSTRATED. THE USE OF DIFFERENTIAL THERMAL ANALYSIS FOR THE DETERMINATION OF THE GLASS TRANSITION OF POLYMERS AND PLASTICIZED POLYMER SYSTEMS AND IN THE DETERMINATION OF POLYMER CRYSTALLINITY IS SHOWN. THERMOGRAVIMETRY IS DEMONSTRATED AS A USEFUL TOOL IN THE DETERMINATION OF COPOLYMER COMPOSITION AND IN THE DETERMINATION OF THE THERMAL STABILITY OF POLYMERS. RELATIVE DEGREE OF CROSS- LINKING OR CURE AND THE DETERMINATION OF HEAT DISTORTION TERMPERATURE OF POLYESTERS HAVE BEEN DETERMINED ON THE THERMAL MECHANICAL ANALYZER. SPECIFIC HEATS AND HEATS OF REACTION HAVE BEEN EXAMINED BY THE USE OF MICROCALORIMETRY. /AUTHOR/
Esterified Hyaluronic Acid and Autologous Bone in the Surgical Correction of the Infra-Bone Defects (2009)

We study the osteoinductive effect of the hyaluronic acid (HA) by using an esterified low-molecular HA preparation (EHA) as a coadjuvant in the grafting processes to produce bone-like tissue in the presence of employing autologous bone obtained from intra-oral sites, to treat infra-bone defects without covering membrane. We report on 9 patients with periodontal defects treated by EHA and autologous grafting (4 males and 5 females, all non smokers, with a mean age of 43.8 years for females, 40.0 years for males and 42 years for all the group, in good health) with a mean depth of 8.3 mm of the infra-bone defects, as revealed by intra-operative probes. Data were obtained at baseline before treatment and after 10 days, and subsequently at 6, 9, and 24 months after treatment. Clinical results showed a mean gain hi clinical attachment (gCAL) of 2.6mm of the treated sites, confirmed by radiographic evaluation. Such results suggest that autologous bone combined with EHA seems to have good capabilities in accelerating new bone formation in the infra-bone defects.
Analysis of hybrid photonic crystal vertical cavity surface emitting lasers (2003)

Vertical resonators with a top mirror constituted of 1D photonic crystal membrane on top of a Bragg stack are investigated in this paper. These structures allow the fabrication of compact vertical-cavity surfaceemitting lasers, which can be designed, in addition, for in-plane emission. With this hybrid approach, fabrication problems related to both classical VCSEL and Photonic Crystal lasers may be significantly relaxed, given that a full Bragg stack is replaced by a single photonic crystal membrane and that the Photonic Crystal is not formed in the active gain layer.
A New Quantitative Indicator of Visual Fatigue (1987)

Ocular-motor correlates of visual fatigue have remained elusive. Performance of ocular-motor tracking with a wide-band white noise input and the response of the dual-mode, smooth pursuit-saccadic eye movement system as output was used to test visual fatigue. A new visual fatigue indicator, VFI, was defined as the nonlinear remnant after subtracting an identified impulse response contribution to the output. Subjects were required to perform very fatiguing CRT screen reading tasks, and the VFI correlated well with the subjective reports of visual fatigue.
Long-term Forecasting using Tensor-Train RNNs (2017)

We present Tensor-Train RNN (TT-RNN), a novel family of neural sequence architectures for multivariate forecasting in environments with nonlinear dynamics. Long-term forecasting in such systems is highly challenging, since there exist long-term temporal dependencies, higher-order correlations and sensitivity to error propagation. Our proposed tensor recurrent architecture addresses these issues by learning the nonlinear dynamics directly using higher order moments and high-order state transition functions. Furthermore, we decompose the higher-order structure using the tensor-train (TT) decomposition to reduce the number of parameters while preserving the model performance. We theoretically establish the approximation properties of Tensor-Train RNNs for general sequence inputs, and such guarantees are not available for usual RNNs. We also demonstrate significant long-term prediction improvements over general RNN and LSTM architectures on a range of simulated environments with nonlinear dynamics, as well on real-world climate and traffic data.
Biology of chronic lymphocytic leukemia. (1987)

Chronic lymphocytic leukemia (CLL) is a clonal proliferation of mature-appearing, but maturationally immature B cells; T cells are rarely involved. Most data suggest that CLL cells are frozen at an early step in maturation; this can be overcome by several techniques such as in vitro incubation with tumor promotors. Although B-CLL involves B cells, and abnormal T cell function is common, its etiology is uncertain. Oncogene abnormalities and retroviral infection have been reported in rare cases of CLL; their role in more typical cases is unknown.
Control of granulation process by fuzzy logic (2003)

A particle image probe comprising a CCD camera and an image processing system was developed for online monitoring of granule growth in a fluidized bed granulation. Fuzzy logic using a linguistic algorithm employing if-then rules was adopted to control granule growth in fluidized bed granulation. It was found that the system could control granule growth with high accuracy.
HYALURONIDASE ACTIVITY OF ALVEOLAR MACROPHAGES (1968)

Hyaluronidase activity was detected in preparations of isolated rabbit lung alveolar macrophages. The enzyme manifested a pH optimum of 3.9 with no activity detected above pH 5. Analysis of reaction products isolated from digests containing low enzyme concentrations revealed the production of large oligosaccharides from hyaluronic acid without the liberation of free N-acetylglucosamine or glucuronic acid. On the other hand, smaller oligosaccharides and free N-acetylglucosamine were obtained from digests with high concentrations of the crude enzyme. These data in conjunction with the findings of others indicate that macrophages contain hyaluronidase and other enzymes active against polymerized hyaluronic acid and its digestion products.