gebhart/patrepeval huggingface dataset:
Progress of automatic drug delivery in anaesthesia—The ‘Rostock assistant system for anaesthesia control (RAN)’ (2008)

Abstract The main goals of general anaesthesia should include (not exclusively) adequate hypnosis, analgesia and maintenance of vital functions. In addition, neuromuscular blockade (NMB) may be needed for a number of surgical procedures. Patient safety and cost reductions via the minimization of drug consumption and the shortening of post‐operative recovery represent some of the main issues and motivations of automation of anaesthesia. Since the early eighties engineers and physicians joined efforts towards the development of sophisticated closed‐loop control systems for drug delivery in the operating theatre and post‐operatively. First, this paper should be seen as a review about the automatic drug delivery in anaesthesia. A summary is given about the methods of measurement, modelling and general progress of closed‐loop control systems in anaesthesia. In particular, the development of the ‘Rostock assistant system for anaesthesia control (RAN)’ is also described. This system has been developed during the last 15 years at the University of Rostock and various systems and control‐based ideas have been integrated since. With this system the multiple‐input–multiple‐output (MIMO) control of the depth of hypnosis and NMB has been shown to be possible as well as the closed‐loop control of a deep arterial hypotension. Promising results have already been obtained from a first study, which has so far included as many as 22 patients using MIMO control. Copyright © 2008 John Wiley & Sons, Ltd.
Interactions of Acridine Antitumor Agents with DNA: Binding Energies and Groove Preferences (1995)

Absorbance spectroscopy is used to examine the thermodynamic properties associated with the interaction of the experimental antitumor agents N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide (AAC) and N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) with nucleic acids. Placement of the amino substituent at the C9 position on the acridine ring results in marked changes to the acridine chromophore's electronic properties, with the overall charge of AAC increasing to +2 in comparison to DACA's charge of +1 at neutral pH. In comparative DNA binding studies, we examine the influence that the electrostatic properties of these ligands have on the binding energies as well as their effects on enthalpy and entropy contributions. These studies show that placement of the amino moiety at C9 results in 6 times greater DNA binding affinity as compared the deamino analog (DACA). Comparisons of ionic strength dependence for these two analogs reveal a difference in the binding energies of the compounds which can be attributed to electrostatic effects. Further dissection of the enthalpy and entropy components of the binding energy reveals the enhanced electrostatic effects are related to an increased entropy contribution upon formation of the AAC-DNA complex. Groove selectivity of these acridine analogs was probed by examining the binding profiles to native and groove-modified DNAs which included glycosylated T4 DNA and the distamycin-DNA complex. These studies are indicative of minor groove interactions for both compounds with DNA.
Design of TC-OQAM schemes using a generalised nonlinearOQPSK-type format (1999)

It is demonstrated that it is possible to design trellis-coded OQAM schemes on the basis of a signal format recently proposed for describing nonlinearly distorted OQPSK-type signals, by appropriately selecting the set of modulation pulses within that format. In some cases, these signal representations are closely related to the well-known TCM concept as proposed by Calderbank and Mazo. Some examples are given and several relevant features of the proposed class of trellis-coded OQAM schemes are emphasised.
Development of Pitting Resistant Fe-Cr-Mo Alloys (1974)

Because of the resistance of iron-chromium stainless steels to chloride stress corrosion, this alloy system was used as a base for developing superior resistance to various forms of corrosion by means of alloying with molybdenum, nickel, and the six metals of the platinum group. The effects of these alloying elements were evaluated by accelerated laboratory tests for pitting, intergranular, general, and stress corrosion. The optimum ductility and resistance to pitting, intergranular, and stress corrosion were found for an alloy of Fe-28% Cr-4% Mo with carbon not exceeding 0.010% and nitrogen below 0.020% (C+N &lt;0.025%). This alloy resists pitting and crevice corrosion in 10% FeCl3-6H2O at 50 C (122 F) with six crevices on the specimen surfaces, and it resists all intergranular attack on a welded specimen in the boiling ferric sulfate-50% H2SO4 test. Addition of 2% Ni to this alloy extends its general corrosion resistance in oxidizing and organic acids to boiling 10% H2SO4 and 1% HCl, in which it is also self-repassivating. The nickel addition makes the alloy subject to stress corrosion cracking (SCC) in the boiling 45% MgCl2 test, but not in the NaCl wick test, which more nearly simulates plant exposures and cracks 18Cr-8Ni stainless steel. Additions of small-amounts of any of the six platinum metals, e.g., 0.020% Ru, also make the 28Cr-4Mo alloy passive in boiling 10% H2SO4. But only ruthenium, iridium, and osmium do this without impairing pitting resistance in halide solutions. For self-repassivation, 0.50% Ru is required, and this amount makes the alloy subject to stress corrosion in the boiling 45% MgCl2 test, but not in the wick test.
Deinterleaving of radar signals and PRF identification algorithms (2007)

Electronic warfare (EW) receivers are passive receivers which receive emissions from other platforms, and do certain analysis on these emissions. Some EW receivers receive radar pulses, measure the parameter of each pulse received and group the pulses that belongs to the same emitter together to determine the radar parameters for each emitter. These parameters are then compared with values stored for known radar types, to identify the emitter type. Two parts are focused, emitters deinterleaving and PRF-type identification. The deinterleaving is done through parameters clustering. Two parameters are selected for clustering direction of arrival and radio frequency. A self-organising neural network called Fuzzy ART is proposed for clustering. This algorithm has a very good clustering quality and can run in real-time applications.The PRF-type identification is done through time-of-arrival (TOA) analysis. Three previously presented algorithms are combined in new scheme to do the TOA analysis (or PRF-type identification). These algorithms are difference TOA histogram, TOA folding histogram and sequence search algorithm. The complete proposed system has been tested using three different tests. These tests are simple PRI test, jittered PRI test and staggered PRI test. The proposed system identifies up to 90 simple emitters, 20 jittered emitters and 20 staggered emitters. In all tests, the data were simulated and generated using software.
Hardware designs for exactly rounded elementary functions (1994)

This paper presents hardware designs that produce exactly rounded results for the functions of reciprocal, square-root, 2/sup x/, and log/sub 2/(x). These designs use polynomial approximation in which the terms in the approximation are generated in parallel, and then summed by using a multi-operand adder. To reduce the number of terms in the approximation, the input interval is partitioned into subintervals of equal size, and different coefficients are used for each subinterval. The coefficients used in the approximation are initially determined based on the Chebyshev series approximation. They are then adjusted to obtain exactly rounded results for all inputs. Hardware designs are presented, and delay and area comparisons are made based on the degree of the approximating polynomial and the accuracy of the final result. For single-precision floating point numbers, a design that produces exactly rounded results for all four functions has an estimated delay of 80 ns and a total chip area of 98 mm/sup 2/ in a 1.0-micron CMOS technology. Allowing the results to have a maximum error of one unit in the last place reduces the computational delay by 5% to 30% and the area requirements by 33% to 77%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
New Product Development: The Performance and Time-to-Market Tradeoff (1996)

Reduction of new product development cycle time and improvements in product performance have become strategic objectives for many technology-driven firms. These goals may conflict, however, and firms must explicitly consider the tradeoff between them. In this paper we introduce a multistage model of new product development process which captures this tradeoff explicitly. We show that if product improvements are additive (over stages), it is optimal to allocate maximal time to the most productive development stage. We then indicate how optimal time-to-market and its implied product performance targets vary with exogenous factors such as the size of the potential market, the presence of existing and new products, profit margins, the length of the window of opportunity, the firm's speed of product improvement, and competitor product performance. We show that some new product development metrics employed in practice, such as minimizing break-even time, can be sub-optimal if firms are striving to maximize profits. We also determine the minimal speed of product improvement required for profitably undertaking new product development, and discuss the implications of product replacement which can occur whenever firms introduce successive generations of new products. Finally, we show that an improvement in the speed of product development does not necessarily lead to an earlier time-to-market, but always leads to enhanced products.
The impact of information availability and workload characteristics on the performance of job co-allocation in multi-clusters (2006)

In this paper, we utilize a bandwidth-centric job communication model that captures the interaction and impact of simultaneously co-allocating jobs across multiple clusters. We make use of a parallel job model that seeks to capture both local and global communication access patterns. By doing so, we are able to explore scheduling strategies that attempt to improve average job turnaround time by selectively mapping jobs across cluster boundaries in a process known as job co-allocation. In this research, we focus on scheduling strategies that make use of available information such as network link utilization, per-processor bandwidths, and job communication topology in order to make intelligent decisions regarding application partition sizes and job placement. We provide results that help to establish the relationship between the quantity of information available a priori to the scheduler and its ability to improve overall system performance. Additionally, we demonstrate the dramatic impact that salient workload characteristics can have on the effectiveness of co-allocation
Crosslinked poly(ester anhydride)s based on poly(ε‐caprolactone) and polylactide oligomers (2003)

Abstract Resorbable poly(ester anhydride) networks based on ε‐caprolactone, L ‐lactide, and D,L ‐lactide oligomers were synthesized. The ring‐opening polymerization of the monomers yielded hydroxyl telechelic oligomers, which were end‐functionalized with succinic anhydride and reacted with methacrylic anhydride to yield dimethacrylated oligomers containing anhydride bonds. The degree of substitution, determined by 13 C NMR, was over 85% for acid functionalization and over 90% for methacrylation. The crosslinking of the oligomers was carried out thermally with dibenzoyl peroxide at 120 °C, leading to polymer networks with glass‐transition temperatures about 10 °C higher than those of the constituent oligomers. In vitro degradation tests, in a phosphate buffer solution (pH 7.0) at 37 °C, revealed a rapid degradation of the networks. Crosslinked polymers based on lactides exhibited high water absorption and complete mass loss in 4 days. In ε‐caprolactone‐based networks, the length of the constituent oligomer determined the degradation: PCL5‐AH, formed from longer poly(ε‐caprolactone) (PCL) blocks, lost only 40% of its mass in 2 weeks, whereas PCL10‐AH, composed of shorter PCL blocks, completely degraded in 2 days. The degradation of PCL10‐AH showed characteristics of surface erosion, as the dimensions of the specimens decreased steadily and, according to Fourier transform infrared, labile anhydride bonds were still present after 90% mass loss. © 2003 The Authors. Journal of Polymer Science Part A: Polymer Chemistry Published by Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 3788–3797, 2003
Glycerophospholipid and Sphingolipid Species and Mortality: The Ludwigshafen Risk and Cardiovascular Health (LURIC) Study (2014)

Vascular and metabolic diseases cause half of total mortality in Europe. New prognostic markers would provide a valuable tool to improve outcome. First evidence supports the usefulness of plasma lipid species as easily accessible markers for certain diseases. Here we analyzed association of plasma lipid species with mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Plasma lipid species were quantified by electrospray ionization tandem mass spectrometry and Cox proportional hazards regression was applied to assess their association with total and cardiovascular mortality. Overall no differences were detected between total and cardiovascular mortality. Highly polyunsaturated phosphatidylcholine species together with lysophosphatidylcholine species and long chain saturated sphingomyelin and ceramide species seem to be associated with a protective effect. The predominantly circulating phosphatidylcholine-based as well as phosphatidylethanolamine-based ether species and phosphatidylethanolamine species were positively associated with total and cardiovascular mortality. Saturated and monounsaturated phosphatidylcholine species, especially phosphatidylcholine 32∶0 (most probably dipalmitoyl-phosphatidylcholine) and palmitate containing sphingomyelin and ceramide species showed together with 24∶1 containing sphingomyelin and ceramide species strongest positive association with mortality. A quotient of the sums of the six most protective species and the six species with the strongest positive mortality association indicated an almost 3-fold increased risk of mortality, which was higher than the hazard ratio for known risk factors in our cohort. Plasma lipid species levels and especially ratios of certain species may be valuable prognostic marker for cardiovascular and total mortality.
pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity (2015)

The peptide-exchange catalyst, HLA-DM, and its inhibitor, HLA-DO control endosomal generation of peptide/class II major histocompatibility protein (MHC-II) complexes; these complexes traffic to the cell surface for inspection by CD4+ T cells. Some evidence suggests that pH influences DO regulation of DM function, but pH also affects the stability of polymorphic MHC-II proteins, spontaneous peptide loading, DM/MHC-II interactions and DM catalytic activity, imposing challenges on approaches to determine pH effects on DM-DO function and their mechanistic basis. Using optimized biochemical methods, we dissected pH-dependence of spontaneous and DM-DO-mediated class II peptide exchange and identified an MHC-II allele-independent relationship between pH, DO/DM ratio and efficient peptide exchange. We demonstrate that active, free DM is generated from DM-DO complexes at late endosomal/lysosomal pH due to irreversible, acid-promoted DO destruction rather than DO/DM molecular dissociation. Any soluble DM that remains in complex with DO stays inert. pH-exposure of DM-DO in cell lysates corroborates such a pH-regulated mechanism, suggesting acid-activated generation of functional DM in DO-expressing cells.
The bellbird colliery disaster, Cessnock, NSW, 1923 and the mines rescue act, 1925 (2011)

In September 1923, 21 miners perished as the result of a fire and explosions at the Bellbird Colliery near Cessnock, NSW. The account, firstly traces the history and description of the mine, rescue attempts and the recovery efforts using breathing apparatus. Secondly, it identifies the various factors and influences that led to the establishment of mines rescue stations in NSW. Finally, it considers the importance of the disaster to the eventual passage of legislation in the form of the Mines Rescue Act 1925.
Temperature regulation of virulence factors in the pathogen <i>Vibrio coralliilyticus</i> (2011)

Sea surface temperatures (SST) are rising because of global climate change. As a result, pathogenic Vibrio species that infect humans and marine organisms during warmer summer months are of growing concern. Coral reefs, in particular, are already experiencing unprecedented degradation worldwide due in part to infectious disease outbreaks and bleaching episodes that are exacerbated by increasing SST. For example, Vibrio coralliilyticus, a globally distributed bacterium associated with multiple coral diseases, infects corals at temperatures above 27 °C. The mechanisms underlying this temperature-dependent pathogenicity, however, are unknown. In this study, we identify potential virulence mechanisms using whole genome sequencing of V. coralliilyticus ATCC (American Type Culture Collection) BAA-450. Furthermore, we demonstrate direct temperature regulation of numerous virulence factors using proteomic analysis and bioassays. Virulence factors involved in motility, host degradation, secretion, antimicrobial resistance and transcriptional regulation are upregulated at the higher virulent temperature of 27 °C, concurrent with phenotypic changes in motility, antibiotic resistance, hemolysis, cytotoxicity and bioluminescence. These results provide evidence that temperature regulates multiple virulence mechanisms in V. coralliilyticus, independent of abundance. The ecological and biological significance of this temperature-dependent virulence response is reinforced by climate change models that predict tropical SST to consistently exceed 27 °C during the spring, summer and fall seasons. We propose V. coralliilyticus as a model Gram-negative bacterium to study temperature-dependent pathogenicity in Vibrio-related diseases.
Selective Ir-catalysed borylation of polycyclic aromatic hydrocarbons: structures of naphthalene-2,6-bis(boronate), pyrene-2,7-bis(boronate) and perylene-2,5,8,11-tetra(boronate) esters (2005)

The selectivity of the iridium boryl complex-catalysed reaction of pyrene and perylene with B2(pin)2 (pin = OCMe2CMe2O) has been employed in the synthesis of D(2h)-symmetry pyrene-2,7-(Bpin)2 and D(4h)-symmetry perylene-2,5,8,11-(Bpin)4 providing direct borylation of positions which are otherwise difficult to derivatise.
Michael Reactions of Pyridinium‐1‐alkylacetamides (1983)

Michael‐Reaktionen von Pyridinium‐1‐alkylacetamiden Die leicht aus Methylpyridinium‐1‐acetat und primären Aminen zugänglichen Pyridinium‐1‐alkylacetamide 5 reagieren mit Chalconen und Natriummethylat in Ethanol in hohen Ausbeuten zu 3‐alkylaminocarbonylsubstituierten Tetrahydroindolizinen 6 . Diese unterliegen einer schnellen und kompletten Ringöffnung mit Essigsäure zu Pyridiniumsalzen 8 . Analoge Salze 7 erhält man direkt aus den Pyridinium‐1‐alkylacetamiden 5 durch Michael‐Addition an die Chalcone in Gegenwart von Dimethylamin als Katalysator. Um diese Michael‐Addukte zu den N‐Alkyl‐4, 6‐diaryl‐2‐pyridonen 9 zu cyclisieren, sind hohe Temperaturen erforderlich. Dabei werden niedrige Ausbeuten an diesen Produkten erzielt. Weiterhin entstehen die NH‐Pyridone und Chalcone als Nebenprodukte.
History of Oral Tolerance and Mucosal Immunitya (1996)

Mucosal immunity depends on antigen stimulation in specialized lymphoepithelial structures such as the Peyer's patches. Although these inductive compartments were discovered more than 300 years ago, their functional role has become clear only over the last few decades. Research on homing of primed lymphoid cells to the intestinal mucosa began with animal experimentation in the 1960s and 1970s and has recently been brought to the molecular level. The major effector substance of mucosal immunity is secretory IgA (SIgA). The first evidence for its local antibody activity was obtained in humans in 1922, but its unique properties were not defined until the mid-1960s. Several models were subsequently proposed for selective external transport of IgA involving the secretory component (SC). In the early 1970s SC was suggested to act as a transmembrane polymeric Ig receptor common for dimeric IgA and pentameric IgM; this transport mechanism has now been confirmed by detailed studies at the level of cellular/molecular biology. Although SIgA antibodies performing immune exclusion are the main goal for exploitation of the mucosal immune system by oral vaccination, little is known about the precise mechanisms for induction of mucosal immunity against soluble proteins and chemicals. A peripheral immunosuppressive effect of oral immunization with such substances was apparently exploited by ancient people, and "oral tolerance" has since 1910 been subjected to numerous feeding experiments in rodents. The basis for the whole phenomenon appears to be intact epithelial barrier. Mucosal induction of suppression may in the future be exploited not only to modulate autoimmune diseases through the gut but also to prevent the development of IgE-mediated allergy and other untoward immune reactions by way of the respiratory tract.
Effects of Forwarders on TCP Performance in Network Coding for Wireless Mesh Networks (2010)

Most traffic in the real internet is TCP traffic. Therefore newly proposed network coding schemes must consider their effects on TCP performance. However, in most studies on network coding, performance evaluation has been conducted using other types of traffic than TCP traffic because network coding has effects on the pattern of packet transmission, which again can impact TCP performance. In most packet transmission schemes based on network coding for wireless mesh networks, it is determined which node, among the ones that received a broadcasted packet, should encode and forward it. In this paper, we examine how the forwarder nodes impact TCP performance.
A substrate-induced conformation change in the reaction of alkaline phosphatase from <i>Escherichia coli</i> (1969)

1. Benzyl phosphonates were prepared and their potentialities as chromophoric reagents for the exploration of the substrate-binding site of Escherichia coli alkaline phosphatase were investigated. 4-Nitrobenzylphosphonate is a competitive inhibitor of the enzyme. 2-Hydroxy-5-nitrobenzylphosphonate changes its spectrum on binding to the enzyme. This spectral change is reversed when the phosphonate is displaced from the enzyme by substrate. 2. The kinetics of the reaction of 2-hydroxy-5-nitrophenylphosphonate were studied by the stopped-flow and the temperature-jump techniques. It was found that the combination of the phosphonate with the enzyme occurred in two successive and reversible steps: enzyme-phosphonate complex-formation followed by rearrangement of the complex. The spectral change is associated with the rearrangement. At pH8 in 1m-sodium chloride at 22 degrees the rate constant is 167sec.(-1) for the rearrangement of the initially formed binary complex and is 18sec.(-1) for the reverse process. 3. It has previously been proposed that the reactions of phosphatase with its substrates include a distinct step between enzyme-substrate combination and chemical catalysis. The rate constant involved could be predicted but not measured from experiments with substrates. The value for the rate constant measured from the rate of the enzyme-phosphonate rearrangement is in excellent agreement with the predicted value. A model for the reaction mechanism is proposed that includes a conformation change in response to phosphate ester binding before phosphate transfer from substrate to enzyme.