gebhart/patrepeval huggingface dataset:
ERdj4 and ERdj5 Are Required for Endoplasmic Reticulum-associated Protein Degradation of Misfolded Surfactant Protein C (2008)

Mutations in the SFTPC gene associated with interstitial lung disease in human patients result in misfolding, endoplasmic reticulum (ER) retention, and degradation of the encoded surfactant protein C (SP-C) proprotein. In this study, genes specifically induced in response to transient expression of two disease-associated mutations were identified by microarray analyses. Immunoglobulin heavy chain binding protein (BiP) and two heat shock protein 40 family members, endoplasmic reticulum-localized DnaJ homologues ERdj4 and ERdj5, were significantly elevated and exhibited prolonged and specific association with the misfolded proprotein; in contrast, ERdj3 interacted with BiP, but it did not associate with either wild-type or mutant SP-C. Misfolded SP-C, ERdj4, and ERdj5 coprecipitated with p97/VCP indicating that the cochaperones remain associated with the misfolded proprotein until it is dislocated to the cytosol. Knockdown of ERdj4 and ERdj5 expression increased ER retention and inhibited degradation of misfolded SP-C, but it had little effect on the wild-type protein. Transient expression of ERdj4 and ERdj5 in X-box binding protein 1(-/-) mouse embryonic fibroblasts substantially restored rapid degradation of mutant SP-C proprotein, whereas transfection of HPD mutants failed to rescue SP-C endoplasmic reticulum-associated protein degradation. ERdj4 and ERdj5 promote turnover of misfolded SP-C and this activity is dependent on their ability to stimulate BiP ATPase activity.
Relationships between plasma levels of type-II phospholipase A2, PAF-acetylhydrolase, leukotriene B4, complements, endothelin-1, and thrombomodulin in patients with sepsis. (1994)

We determined the plasma levels of type-II phospholipase A2 (type II PLA2), platelet-activating factor acetylhydrolase (PAFAH) leukotriene B4 (LTB4) and of several complements (C3a, C4a, and C5a), which are considered to be among the cytokines and eicosanoids involved in vascular endothelial disorders and that vary in concentration during sepsis. We investigated the relationship between those levels and those of ET-1 and TM levels in plasma. Plasma levels of type II PLA2, PAFAH, LTB4, C3a, C4a, ET-1, and TM at the time that sepsis was diagnosed in 30 patients were 218.3 +/- 179.9 ng/ml, 23.92 +/- 9.66 nmol/min/ml, 90.35 +/- 31.49 pg/ml, 838.73 +/- 2.30 pg/ml, 1951.46 +/- 1697.78 pg/ml, 6.98 +/- 4.08 pg/ml and 7.80 +/- 3.34 ng/ml, respectively. The C5a plasma level was below the limit of detection in all cases. There were significant correlations between type II PLA2 and ET-1 plasma levels (r = 0.39, p = 0.032) and C3a and ET-1 plasma levels (r = 0.60, p = 0.03). There were also significant correlations between type II PLA2 and TM levels in plasma (r = 0.76, p = 0.0017), PAFAH and TM plasma levels (r = 0.53, p = 0.037), LTB4 and TM plasma levels (r = 0.46, p = 0.016) and C4a and TM plasma levels (r = 0.58, p = 0.037). Results suggest that the elevation of type II PLA2, PAFAH, LTB4 and complement in plasma is involved in vascular endothelial disorders in patients with sepsis.
Hold time validation on silicon and the relevance of hazards in timing analysis (2006)

In this paper we motivate the explicit validation of hold-time violations in silicon and propose a method for doing so. New hold-time failure model and test pattern generation methodologies are defined.We outline conditions under which these tests can be applied reliably. We present results of applying these test patterns on a microprocessor and discuss the implications of intermittent failures on the relevance of hazards during timing analysis.
Secondary electron emission yields from MgO deposited on carbon nanotubes (2001)

Enormously high secondary electron emission yields under electric field are observed from MgO deposited on carbon nanotubes. The yields reach a value as high as 15 000 and are strongly dependent upon the bias voltage applied to the sample. The creation of the electric field across the MgO film after bombardment of primary electrons is considered as one of key features, since positive charges are generated at the surface by departure of secondary electrons. Subsequent bombarding electrons produce other secondary electrons inside the MgO film, then the liberated secondaries are accelerated towards the surface under the strong field. Under this condition, the secondary electrons gain sufficient energy to create further electrons by impact ionization. The process continues until an equilibrium avalanche is established. To elucidate the earlier explanations, the kinetic energy spectra of secondary electrons are measured by an energy analyzer at various bias voltages in MgO/carbon nanotube samples. The analysis of spectral results with the energy band diagram gives us strong evidence for the suggested mechanism.
Daily patient set-up control in radiation therapy by coded light projection (2002)

Advances in conformal radiation therapy to control disease via dose escalation are challenged by set-up uncertainties. Recently, techniques have been developed to use surface features to evaluate the patient's position and correct it where necessary. The aim of this study was to use the patient's surface as a tool for daily set-up control and monitoring. We use a surface scanner based on the projection of coded light to receive--in a daily routine--a large amount of surface points which enables us to register the CT-based planning data with the patients current position. By superimposing current and planned volumes, a volume of congruency was obtained. An error below 1 mm was considered acceptable. In cases where set-up was not satisfactory a map of the surface comparison was evaluated showing the areas of missing alignment. According to this information a manual repositioning was performed. This procedure was repeated until the error was acceptable. No more then 3 repetitions where necessary to obtain an acceptable result. The whole procedure including registration, calculation and visualization took about 20 sec for one repetition. The use of structured light projection in the daily set-up control and monitoring proved to be a noninvasive, easy, quick, inexpensive and reliable solution.
Murine neuroblastoma: further evaluation of the C1300 model with single antitumor agents. (1976)

The murine C1300 neuroblastoma model has been evaluated as a possible model for children with widespread metastatic disease. Drug toxicity studies were conducted in adult A/J mice with various doses of antitumor agents. Adriamycin, BCNU, bleomycin, guanazole, acronycine, isophosphamide, DTIC, ICRF-159, cyclophosphamide, vincristine, and vinblastine were adminstered intraperitoneally to random groups of normal mice. After identification of appropriate doses, chemotherapy studies were conducted with varius regimens of drugs. Chemotherapy was administered to adult A/J mice when their subcutaneously implanted tumors measured 1.0-1.7 cm in diameter. Antitumor drugs can be classified into three groups according to drug efficacy. BCNU, cyclophosphamide, and isophosphamide were extremely active. Cytosine arabinoside was reported to be active against this murine tumor in a previous publication. Drugs with minimal activiyt which deserve further evaluation included adriamycin, guanazole, ICRF-159, DTIC, and vinblastine. Inactive drugs were acronycine, bleomycin, 5-fluorouracil, and vincristine. These experiments suggest that children with metastatic neuroblastoma may respond to cyclophosphamide, isophosphamide, and BCNU, while DTIC, adriamycin, ICRF-159, guanazole, and the vinca alkaloids may also be effective. The results suggest that agents selected by the C1300 model should be given adequate clinical trials.
Catalyst cartridge for carbon dioxide reduction unit (1973)

A catalyst cartridge, for use in a carbon dioxide reducing apparatus in a life support system for space vehicles, is described. The catalyst cartridge includes an inner perforated metal wall, an outer perforated wall space outwardly from the inner wall, a base plate closing one end of the cartridge, and a cover plate closing the other end of the cartridge. The cover plate has a central aperture through which a supply line with a heater feeds a gaseous reaction mixture comprising hydrogen and carbon dioxide at a temperature from about 1000 to about 1400 F. The outer surfaces of the internal wall and the inner surfaces of the outer wall are lined with a ceramic fiber batting material of sufficient thickness to prevent carbon formed in the reaction from passing through it. The portion of the surfaces of the base and cover plates defined within the inner and outer walls are also lined with ceramic batting. The heated reaction mixture passes outwardly through the inner perforated wall and ceramic batting and over the catalyst. The solid carbon product formes is retained within the enclosure containing the catalyst. The solid carbon product formed is retained within the enclosure containing the catalyst. The water vapor and unreacted carbon dioxide and any intermediate products pass through the perforations of the outer wall.
Eya‐six are necessary for survival of nephrogenic cord progenitors and inducing nephric duct development before ureteric bud formation (2015)

Our data support a model where Eya-Six may form a complex to regulate nephron progenitor cell development before metanephric specification and are critical mesenchymal factors for inducing nephric duct development.
INVESTIGATION OF THE EFFECT OF SWELLING AND SHRINKAGE ON THE WRINKLING RESPONSE OF LOCALLY WETTED PAPERS SUBJECTED TO TENSION WITH APPLICATION TO WEB-FED INK-JET PRINTING (2007)

For web-fed ink-jet printing, wrinkling can occur during printing and persist and become worse after sheeting.The wrinkles formed during local wetting and drying was successfully characterized using a lab scale system complemented with the simple moir fringe technique.The two main parameters used to characterize these wrinkles were the wavelength and the height of the wrinkles.A buckling analysis was completed for the prediction of wet wrinkles which provided an expression for the critical load at which paper buckles to form wrinkles and an expression for the wavelength.A new method was developed to measure the wet expansion and subsequent shrinkage on drying of a sheet.It was found that wet wrinkling occurs due to the restriction of swelling of the sheet upon wetting.During drying, wet wrinkling is diminished and new wrinkling occurs due to subsequent shrinkage of the wetted regions.
A Closer Look at the Structure of Sterically Stabilized Liposomes: A Small-Angle X-ray Scattering Study (2010)

The evaluation of the radial electron density profile of a drug containing a sterically stabilized liposomal system is described. Using synchrotron small-angle X-ray scattering, we were able to characterize the hydrophilic shell of the polyethylene glycol chains. Using a Gaussian model for describing the electron density profile along the normal of the bilayer, we got an asymmetric distribution of PEGylated lipids in accordance with theoretical considerations. Moreover, we used anomalous X-ray scattering to study the localization of a hydrophobic drug (a kinase inhibitor), which revealed that these molecules are mainly located in the hydrocarbon chain region of the phospholipid bilayer.
A low spurious and small step frequency synthesizer based on PLL-DDS-PLL architecture (2008)

This paper describes a low spurious and small step frequency synthesizer module based on PLL (Phase-Locked Loop)-DDS (Direct Digital Synthesis)-PLL structure, which is controlled by the parallel port of the computer. The module consists of four parts: the first PLL (PLL1), the DDS, the second PLL (PLL2) and the control part. The spurious of this module is ameliorated to some extent in comparison with traditional synthesizer technologies using single PLL. The experimental measurement of the actual module shows that the spurious is as low as -65 dBc. In addition, its frequency range is 2060 MHz-2160 MHz, the frequency step size 10 kHz, the phase noise -90 dBC/Hz@10 kHz and the harmonics -40 dBc.
Running Microsoft Outlook 2000 (1998)

From the Publisher:
It's packed with everything from quick, clear instructions for new users to comprehensive answers for power users. And it's complete in one volume. In short, Running Microsoft Outlook 98 is the authoritative handbook you'll keep by your computer and use every day. 
Experience Level: Beginner/ Intermediate
No Protective Effect of Acyclovir on HIV Disease Progression in a Cohort of Hsv-2–HIV-Infected Individuals (2002)

The efficacy of anti-herpetic drugs in decreasing HIV disease progression has not been clarified. We studied a cohort of 126 HIV-positive individuals with known date of seroconversion who were HSV-2-seropositive to determine if progression to AIDS was influenced by treatment with acyclovir. In the multivariate analysis, being homosexual and low CD4 count were associated with a faster progression to AIDS, whereas treatment with acyclovir showed a 37.0% protective effect compared to those who did not receive it when antiretroviral treatment was not included in the model. When including antiretroviral therapy, the protective effect of acyclovir decreased to 9.0% and that of antiretroviral therapy was 43.0% for monotherapy and 36.0% for double therapy, suggesting that most of the protective effect of acyclovir in the previous model was due to antiretroviral therapy. In conclusion, treatment with acyclovir does not seem to prolong significantly survival to AIDS among HIV-positive individuals who are HSV-2-infected.
Development of rapid heating and cooling systems for injection molding applications (2002)

Abstract The injection molding process has several inherent problems associated with the constant temperature mold. A basic solution is the rapid thermal response molding process that facilitates rapid temperature change at the mold surface thereby improving quality of molded parts without increasing cycle time. Rapid heating and cooling systems consisting of one metallic heating layer and one oxide insulation layer were investigated in this paper. Design issues towards developing a mold capable of raising temperature from 25°C to 250°C in 2 seconds and cooling to 50°C within 10 seconds were discussed. To reduce thermal stresses in the layers during heating and cooling, materials with closely matched low thermal expansion coefficient were used for both layers. Effects of various design parameters, such as layer thickness, power density and material properties, on the performance of the insert were studied in detail with the aid of heat transfer simulation and thermal stress simulation. Several rapid thermal response mold inserts were constructed on the basis of the simulation results. The experimental heating and cooling response agrees with the simulation and also satisfies the target heating and cooling requirement.
<i>Neutron Cross Sections</i> (1958)

Share Icon Share Twitter Facebook Reddit LinkedIn Reprints and Permissions Cite Icon Cite Search Site Citation Donald J. Hughes, Lyle B. Borst; Neutron Cross Sections. Physics Today 1 April 1958; 11 (4): 43. https://doi.org/10.1063/1.3062525 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPhysics Today Search Advanced Search
Dynamic contrast‐enhanced (DCE) derived transfer coefficient (k<sup>trans</sup>) is a surrogate marker of matrix metalloproteinase 9 (MMP‐9) expression in brain tuberculomas (2008)

We conclude that the expression of MMP-9, a marker of BBB disruption and disease activity in BT correlates with DCE-derived ktrans and thus has the potential to be used as its surrogate marker.
Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses (2016)

NF-κB plays a variety of roles in oncogenesis and immunity that may be beneficial for therapeutic targeting, but strategies to selectively inhibit NF-κB to exert antitumor activity have been elusive. Here, we describe IT-901, a bioactive naphthalenethiobarbiturate derivative that potently inhibits the NF-κB subunit c-Rel. IT-901 suppressed graft-versus-host disease while preserving graft-versus-lymphoma activity during allogeneic transplantation. Further preclinical assessment of IT-901 for the treatment of human B-cell lymphoma revealed antitumor properties in vitro and in vivo without restriction to NF-κB-dependent lymphoma. This nondiscriminatory, antilymphoma effect was attributed to modulation of the redox homeostasis in lymphoma cells resulting in oxidative stress. Moreover, NF-κB inhibition by IT-901 resulted in reduced stimulation of the oxidative stress response gene heme oxygenase-1, and we demonstrated that NF-κB inhibition exacerbated oxidative stress induction to inhibit growth of lymphoma cells. Notably, IT-901 did not elicit increased levels of reactive oxygen species in normal leukocytes, illustrating its cancer selective properties. Taken together, our results provide mechanistic insight and preclinical proof of concept for IT-901 as a novel therapeutic agent to treat human lymphoid tumors and ameliorate graft-versus-host disease.
TorchGAN: A Flexible Framework for GAN Training and Evaluation (2021)

TorchGAN is a PyTorch based framework for writing succinct and comprehensible code for training and evaluation of Generative Adversarial Networks. The framework's modular design allows effortless customization of the model architecture, loss functions, training paradigms, and evaluation metrics. The key features of TorchGAN are its extensibility, built-in support for a large number of popular models, losses and evaluation metrics, and zero overhead compared to vanilla PyTorch. By using the framework to implement several popular GAN models, we demonstrate its extensibility and ease of use. We also benchmark the training time of our framework for said models against the corresponding baseline PyTorch implementations and observe that TorchGAN's features bear almost zero overhead.
360‐MHz <sup>1</sup>H Nuclear‐Magnetic‐Resonance Spectroscopy of Sialyl‐Oligosaccharides form Patients with Sialidosis (Mucolopidosis I and II) (1978)

360-MHz proton nuclear magnetic resonance spectra were recorded of 10 sialyl-oligosaccharides isolated from urine of sialidosis patients. Their structures are related to the complex asparagine-linked glycan chains of glycoproteins. By correlation of these spectra and comparison with spectra of reference glycopeptides and sialyl-lactose isomers it was possible to assign all signals belonging to anomeric, mannose H-2, sialic acid H-3 and N-acetyl protons. The number of the consituting monosaccharide residues of the oligomers can be obtained by integration of the above-mentioned signals. The chemical shifts of the anomeric and mannose H-2 protons give information about the type of glycan structure (mono-, bi-, triantennary) and the presence of terminal sialic acid at each of the antennas. The chemical shifts of sialic acid H-3 protons are typical for sialic acid residues in 2 leads to 3 or 2 leads to 6 linkage to galactose.
Correction: Systematic Two-Hybrid and Comparative Proteomic Analyses Reveal Novel Yeast Pre-mRNA Splicing Factors Connected to Prp19 (2011)

Prp19 is the founding member of the NineTeen Complex, or NTC, which is a spliceosomal subcomplex essential for spliceosome activation. To define Prp19 connectivity and dynamic protein interactions within the spliceosome, we systematically queried the Saccharomyces cerevisiae proteome for Prp19 WD40 domain interaction partners by two-hybrid analysis. We report that in addition to S. cerevisiae Cwc2, the splicing factor Prp17 binds directly to the Prp19 WD40 domain in a 1:1 ratio. Prp17 binds simultaneously with Cwc2 indicating that it is part of the core NTC complex. We also find that the previously uncharacterized protein Urn1 (Dre4 in Schizosaccharomyces pombe) directly interacts with Prp19, and that Dre4 is conditionally required for pre-mRNA splicing in S. pombe. S. pombe Dre4 and S. cerevisiae Urn1 co-purify U2, U5, and U6 snRNAs and multiple splicing factors, and dre4D and urn1D strains display numerous negative genetic interactions with known splicing mutants. The S. pombe Prp19-containing Dre4 complex co-purifies three previously uncharacterized proteins that participate in pre-mRNA splicing, likely before spliceosome activation. Our multi-faceted approach has revealed new low abundance splicing factors connected to NTC function, provides evidence for distinct Prp19 containing complexes, and underscores the role of the Prp19 WD40 domain as a splicing scaffold.
PIUS THE ELEVENTH (1939)

Whoever would write about a modern pope labours under serious handicaps. The public utterances of the popes are veiled by a conventional language that most effectually muffles their personality. In the action of the Roman See upon the universal Church during the time they are its bishop, it is not by any means easy to disentangle the part of the pope and the part of the high official whose trained mind is the papal instrument. Convention, again, seals the mouths of those who could speak about the personal reactions of the pope whether to the personalities who cross his path or to the crises of his reign. And once the pope is dead interest shifts rapidly to his successor. In the reign of that successor, in the press of business and of actuality that absorbs the high officials of the Curia from the moment of the new pope’s election, there is little leisure left for the composition of memoirs by those who really knew the pope who has died. The portrait of a pope has thus to be built up from scanty materials indeed, and the most promising of these, from the biographical artist’s point of view, are only too often sadly lacking in authenticity. If Pius XI had been a letter writer as industrious as Queen Victoria, if he had kept a diary, and if there were any chance of these documents seeing the light, then we might, some one might, at some future day, be in a position really to analyse his personality in the best French manner, and set his greatness before the world with the skill of a Gainsborough or a Goya. As it is . . .
Concentrating Cellulases from Fermented Broth Using a Temperature‐Sensitive Hydrogel (1992)

Abstract A temperature‐sensitive poly( N ‐isopropylacrylamide) hydrogel was used to concentrate cellulases from the fermentation broth of Trichoderma reesei . The steady‐state gel volume was less and the gel collapse temperature was lower in fermented broth compared to those in water. Upon a long (24 h) temperature swing for gel swelling, a gel with lower monomer and cross‐linker content showed a larger volume increase, and it took longer to reach a constant volume which was smaller than the steady‐state volume. Upon a long (24 h) temperature swing for gel collapsing, different gels reached the same collapsed volume in a short period of time. The largest volume increase per unit temperature decrease was obtained for a temperature swing between 28 and 33 °C. For short temperature swings (1–5 h), swollen and collapsed gel volumes were reproducible and were approximately the same as the final volumes during long (24 h) swings. Separation efficiency was higher for the gel with a smaller volume change because of higher concentrations of monomer or cross‐linking agent. When the gels were reused, separation efficiency was improved.