gebhart/patrepeval huggingface dataset:
The ictal EEG as a marker of adequate stimulus intensity with unilateral ECT (1995)

Relative stimulus intensity above seizure threshold has been shown to affect therapeutic outcome with unilateral ECT. The authors sought to explore whether a multivariate ictal EEG model would permit ongoing clinical assessment of this parameter. Twenty-five depressed subjects were randomized to either barely (T) or moderately (2.5T) suprathreshold ECT treatments. Seizures in 2.5T subjects had significantly greater ictal spectral amplitude and coherence, greater postictal suppression, and shorter latency until ictal slow-wave onset. A multivariate logistic regression ictal EEG model distinguished between stimulus intensity groups with 90% accuracy. Preliminary evidence suggests a relationship between several ictal EEG indices and therapeutic outcome. A multivariate ictal EEG algorithm holds promise as a tool for clinical determination of adequate stimulus intensity with unilateral ECT.
Geographic spread of epidemic multiresistant Staphylococcus aureus clone in Brazil (1995)

Staphylococcus aureus isolates from five large teaching hospitals and one medium-size community hospital located in geographically distant parts of Brazil, in the south and southeast (Rio de Janeiro, Niteroi, Sao Paulo, Porto Alegre) and in the north (Manaus), were tested for their antibiotic resistance patterns and genetic backgrounds. Eighty-five of the 152 isolates were identified as methicillin-resistant S. aureus (MRSA) by using a combination of an agar dilution screen and a mecA gene-specific DNA probe. All MRSA isolates were resistant to penicillin, erythromycin, gentamicin, oxacillin, and cephalothin, and the majority of isolates (74%) were also resistant to chloramphenicol, sulfamethoxazole-trimethoprim, ciprofloxacin, and clindamycin as well and were susceptible only to vancomycin. Isolates obtained from hospitals in Sao Paulo, Rio de Janeiro, Niteroi, and Porto Alegre (1,600 km from one another) and Manaus (3,700 km from Rio de Janeiro) were examined by a variety of molecular fingerprinting techniques: the nature of the mecA polymorph and Tn554 attachment sites and restriction fragment length polymorphism of genomic DNAs after SmaI restriction and separation of the digested DNA by pulsed-field gel electrophoresis. The overwhelming majority of the isolates shared a common pulsed-field gel electrophoresis pattern and carried mecA polymorph III in combination with Tn554 pattern B, indicating the presence of a single, epidemic MRSA clone spread over large geographic distances of Brazil.
On Hotelling's Approach to Testing for a Nonlinear Parameter in Regression (1989)

Mark Knowles, David Siegmund, On Hotelling's Approach to Testing for a Nonlinear Parameter in Regression, International Statistical Review / Revue Internationale de Statistique, Vol. 57, No. 3 (Dec., 1989), pp. 205-220
Proteomic Strategies and Their Application in Studies of Renal Function (2004)

Proteomics is a promising new tool for functional genomics. In addition to two-dimensional gel electrophoresis, other methods that are based on liquid chromatography and mass spectrometry are now available to study proteins. In this brief article, we review the strengths and limitations of the proteomic approaches currently available to the researcher, and we provide examples of how proteomics has been, and can in the future be, used to study the kidney.
Una guía práctica para la elaboración, diseño e implementación de un proyecto de dinamización artística. (2014)

Artistic revitalization projects have a number of common features when developing them, designing and implementing them. This article presents a seven-step guide for developing an art project, ranging from an understanding of the environment in which we move through the project creation and subsequent DAFO, to a search for funding and publicity for our proposal. This guide will help you sort the ideas in drawing, design and implement an artistic revitalization Project.
Piezophysiology of membrane-based adaptations in the deep-sea bacterium Photobacterium profundum strain SS9 (2002)

Biological membranes are highly dynamic complex structures exquisitely tuned to alterations in the state of the physical environment. Increased hydrostatic pressure and reduced temperature elicit similar physical influences on the phase and fluidity properties of biological membranes. As hydrostatic pressure is increased, or temperature is decreased, membranes undergo a reversible change from a fluid disordered state to a non-fluid ordered state resulting in membrane supraoptimal viscosity or phase transition. These deleterious consequences result to a large extent from the close packing of phospholipid fatty acyl chains within the membrane bilayer. In the absence of corrective membrane restructuring events to alleviate this perturbation, a host of membrane localized essential processes are prone to inactivation. Consequently, preservation of a suitable membrane dynamic state is of paramount importance in allowing an organism to adapt accordingly to prevailing environmental conditions. In this dissertation, the relative importance of unsaturated fatty acids (UF As) to growth at high pressure and low temperature has been evaluated employing the piezophilic deep-sea bacterium Photobacterium profundum strain SS9. SS9 modulates the levels of numerous fatty acid species in response to pressure and temperature change resulting in enhanced levels of UF As at high pressure and low temperature. Analysis of SS9 mutant strains exhibiting altered fatty acid profiles have revealed particular classes of UFA species important for growth at high pressure and low temperature. Furthermore, molecular genetic analyses of genes responsible for UFA synthesis have identified multiple genes required for pressure-responsive UFA production. The fatty acid biosynthetic condensing enzymes FabF (KAS II) and FabB (KAS I) are required for high pressure regulation of 18: 1 synthesis and growth at elevated pressure. In addition, the genes responsible for omega-3 polyunsaturated fatty acid (PUF A) synthesis in SS9 have been characterized. PUF A levels undergo both pressure- and temperature-dependent modulations yet they are not required for growth under these conditions. Lastly, the involvement of the global transcription factor CRP is evidenced to influence UFA synthesis in SS9. Overall, these studies present a comprehensive analysis of membrane-based adaptations important for growth and survival under elevated pressure and low temperature conditions.
Does Zinc Moderate Essential Fatty Acid and Amphetamine Treatment of Attention-Deficit/Hyperactivity Disorder? (2000)

Zinc is an important co-factor for metabolism relevant to neurotransmitters, fatty acids, prostaglandins, and melatonin, and indirectly affects dopamine metabolism, believed intimately involved in attention-deficit/hyperactivity disorder (ADHD). To explore the relationship of zinc nutrition to essential fatty acid supplement and stimulant effects in treatment of ADHD, we re-analyzed data from an 18-subject double-blind, placebo-controlled crossover treatment comparison of d-amphetamine and Efamol (evening primrose oil, rich in gamma-linolenic acid). Subjects were categorized as zinc-adequate (n = 5), borderline zinc (n = 5), and zinc-deficient (n = 8) by hair, red cell, and urine zinc levels; for each category, placebo-active difference means were calculated on teachers' ratings. Placebo-controlled d-amphetamine response appeared linear with zinc nutrition, but the relationship of Efamol response to zinc appeared U-shaped; Efamol benefit was evident only with borderline zinc. Placebo-controlled effect size (Cohen's d) for both treatments ranged up to 1.5 for borderline zinc and dropped to 0.3-0.7 with mild zinc deficiency. If upheld by prospective research, this post-hoc exploration suggests that zinc nutrition may be important for treatment of ADHD even by pharmacotherapy, and if Efamol benefits ADHD, it likely does so by improving or compensating for borderline zinc nutrition.
56-Gb/s Optical SSB PAM-4 Transmission over 800-km SSMF Using DDMZM Transmitter and Simplified Direct Detection Kramers-Kronig Receiver (2018)

We propose and experimentally demonstrate a simplified direct detection Kramer-Kronig (DD-KK) receiver followed by a Volterra filter to mitigate the SSBI and fiber nonlinearity in a 56-Gb/s optical SSB PAM-4 transmission over 800-km SSMF.
The Future of Judicial Independence in China (2017)

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俞思远专访:有一个梦,始终在疯 (2007)

他是新势力,2006年在一场盛世华丽的比赛中,他以音速穿透了人心,而他的22岁也从此开始跌跌撞撞地向一个未知世界走去。站在这个舞台上,他在旁人的侧目和台下的尖叫中征服一切,等舞台灯光熄灭,撤走了架子鼓、话筒、音箱、效果器,他又沉溺到自己的角落。在他人生到现在为止的所有阶段,他以他的全部去接近现实,在那睁不开眼的光芒中蜕变,也许曾有那么一丝他未曾觉察到的痛楚滑过心口,他要自己不去介意,然后再一个回头,他已经成为现在的他,愿意不愿意,都成了一个偶像。你每一次都是奋不顾身的么?他咳嗽了两下,想了想,回答说是。在他唱过的歌当中,脱下长日的假面,奔向梦幻的疆界并不是很起眼的一句,但闭上眼睛总是会回想到那一幕:他对着镜头张开双手,眼神中似有千言万语,最后手里还在紧握的,就是那个令他站在这里的梦。娱乐圈是个残酷童话。试图通过这个领域的人都应该明白,背着梦进来,却是梦消亡的过程。他早就明白,却还是倔强地把青春抵押进去,不为别的,只为他是俞思远。
Binding of acrylic polymers to mucin/epithelial surfaces: structure-property relationships. (1988)

Bioadhesion, and more specifically mucoadhesion, is becoming an important strategy for drug delivery. As a result, it is important to understand the various mechanisms that govern attachment of polymeric substances to the glycoproteins on epithelial surfaces, along with the associated structure-activity relationships of the polymer. This article reviews fundamentals of mucoadhesion, with special emphasis on structural features of the polymer as they contribute to the process of mucoadhesion. There are four possible general interactions between mucoadhesive polymers and glycoproteins: (1) covalent attachment; (2) electrostatic interaction, which requires matching of charge groups between the polymer and mucus; (3) hydrogen bonding; and (4) hydrophobic interactions. Aside from covalent attachment, which is not presently a prominent mechanism for mucoadhesion, the remaining mechanisms require maximum contact between the polymer and mucin for optimum adhesion. With polyelectrolyte polymers, the charged groups are important in controlling the degree of hydration of both the polymer and the mucous network. The expanded nature of the swollen polymer and mucus enhances the interdiffusion process and permits both a mechanical entanglement and an increase in surface contact for hydrogen bonding and/or electrostatic interaction between the polymer and the mucous network. A number of techniques are available to study mucoadhesion. Some of these are better suited to study the kinetics of the mucoadhesion process whereas others are more useful for equilibrium studies. To date, the major deficiency in basic studies of mucoadhesion is the lack of suitable information on the organization and physicochemical properties of the mucin layer.
Sub-Nanometer Resolution Ultrasonic Motor for 300 mm Wafer Lithography Precision Stage (2002)

This paper describes the development of the nonresonant ultrasonic motor (NRUSM) applied to a 300-mm-stroke ultra-precision stage for future LSI manufacturing, in particular electron beam based technologies. Advantages of the NRUSM are high resolution, no magnetic noise generation, high servo rigidity and high retention. It is confirmed that the NRUSM is suitable for ultra-precision positioning, and slow- and high-velocity feeding at closed-loop controls. The performance of the NRUSM-driven stage includes; (1) 85 mm/s feed velocity with average acceleration 375 mm/s2 over the 300 mm stroke at open-loop control; (2) ±0.69 nm positioning accuracy at step and repeat response, 17 ms average positioning time for ±30 nm positioning accuracy, positional error during constant velocity feeding below ±1.5 nm for 100 nm/s and ±40 nm for 20 mm/s, and velocity ripple at 36 mm/s is below 0.04% at closed-loop control.
Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction (2007)

We showed that, in sepsis, NO and bacterial elements are responsible for type-specific platelet-derived exosome generation. Those exosomes have an active role in vascular signaling as redox-active particles that can induce endothelial cell caspase-3 activation and apoptosis by generating superoxide, NO and peroxynitrite. Thus, exosomes must be considered for further developments in understanding and treating vascular dysfunction in sepsis.
Rhynchophylline Attenuates LPS‐induced Pro‐inflammatory Responses through Down‐regulation of MAPK/NF‐κB Signaling Pathways in Primary Microglia (2012)

Excessive activation of microglial cells has been implicated in various types of neuroinflammation. Suppression of microglial activation would have therapeutic benefits, leading to the alleviation of the progression of neurodegeneration. In this study, the inhibitory effects of rhynchophylline (RIN), a tetracyclic oxindole alkaloid component isolated from Uncaria rhynchophylla (Miq.) Jacks., on the production of pro-inflammatory mediators were investigated in lipopolysaccharide (LPS)-stimulated microglia. The results showed that RIN markedly reduced the production of nitric oxide (NO), prostaglandins E(2) (PGE(2) ), monocyte chemoattractant protein (MCP-1), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in LPS-activated microglia. The mRNA expression levels of iNOS and COX-2 were also depressed by RIN in a concentration-dependent manner. Further studies revealed that RIN blocked IκBα phosphorylation and degradation, inhibited the phosphorylation of mitogen-activated protein kinases (MAPKs). In summary, these data suggest that RIN suppresses inflammatory responses of microglia and may act as a potential therapeutic agent for various neurodegenerative diseases involving neuroinflammation.
Combinaison cohérente de lasers à cascade quantique (2012)

Powerful sources in the mid-infrared with a good beam quality are highly needed for applications such as optical countermeasures. The quantum cascade laser (QCL) is a promising solution but the maximum power achievable is not sufficient. The coherent beam combining of several QCL could lead to higher output power in the same beam and thus is an interesting solution to circumvent the current power limitation of these sources.We present a theoretical and experimental study of the coherent beam combining of QCL in a common external cavity with a beam combiner. The phase locking is totally passive since it is only based on loss minimization in the external cavity: it is a self-organization process. A general model is developed to quantify the combining efficiency and the stability that can be obtained from this method. Experimentally, the coherent combining of two QCL in a Michelson cavity is studied first and demonstrated to be efficient and stable. In order to combine more emitters, an efficient beam combiner must be designed in the mid-infrared. For that purpose, two type of gratings, a classical binary phase grating (or Dammann grating) and a more complex gradient-index structure made of local sub-wavelength patterns are designed and compared. The calculation and optimization of this sub-wavelength structure is based on the artificial media theory and is achieved with rigorous coupled wave analysis (RCWA). Finally, the coherent combining of five QCL in an external cavity with a binary phase grating is demonstrated and the scalability to the combining of more emitters is discussed. In conclusion, we present an original solution to combine coherently several QCL and thus address the power scaling issue in the mid-infrared.
A hybrid electric vehicle with incorporation of VaReB technology (2014)

The development and Innovative designing of Electrical Locomotives has become the need of the hour in the existing situation globally as a consequence of two major factors. One of them being the steeply rising prices of Crude oil and the constant damage being imposed on the environment due to harmful substances in the atmosphere due IC Engines. The Electric Vehicle essentially consists of BLDC Hub Motor, SMF Batteries, Stock Chassis and the Regenerative Braking module. Regenerative Braking basically transmits the Kinetic Energy of the wheel due momentum into Electrical Energy which is otherwise wasted. The Regenerative module (VaReB) works on the principle of application of Variable Capacitances into the circuit to harness the desired level of Braking and hence the Regenerated Energy.
A Comprehensive Model for Whole Cell Sensing and Transmembrane Potential Measurement Using FET Biosensors (2018)

In this research, the development of a highly sensitive FET based biosensor technology for whole cell sensing and cellular transmembrane potential measurement is discussed and a quantitative model is proposed to elucidate the sensor mechanism. Electrical double layer (EDL) gated FET biosensor platform offers high sensitivity target analyte detection, even in high ionic strength solutions, thereby eliminating the need for complex sample pre-processing methods. Using this sensor platform, we have developed a whole cell sensing technology that can detect and count cells, and monitor cellular bioelectric signals such as transmembrane potential changes. A quantitative model is developed to explain the sensor mechanism and theoretical prediction shows good agreement with experimental results. The changes in the cellular transmembrane potential upon extracellular stimulus is modeled based on the EDL FET sensor response. Our investigation reveals that EDL FET biosensor platform can be used to study the bioelectric signals of cells, dynamically which is highly relevant to cell biology in applications of drug development, ion channel studies and disease model establishment. This sensor technology can also be used for point of care diagnostics, in the diagnosis and prognosis of diseases such as cancer.
Optomechanical crystals and their quantum optical applications (2011)

In the last several years, rapid advances have been made in the field of cavity optomechanics, in which the usually feeble radiation pressure force of light is used to manipulate (and precisely monitor) mechanical motion. These advances have moved the field from the multi-km interferometer of a gravitational wave observatory, to the optical table top, and now all the way down to a silicon microchip. In this talk I will describe these advances, and discuss our own work to realize radiation pressure within nanoscale structures in the form of coupled photonic and phononic crystals (dubbed optomechanical crystals).
New Cytotoxic Peroxylactones from the Marine Sponge, Plakinastrella onkodes (1994)

Three new peroxylactones, plakortolides B [6], C [7], and D [8], and a new peroxy ester, epiplakinic acid E methyl ester [9], were isolated and characterized from a previously unstudied marine sponge, Plakinastrella onkodes. A mixture of steroidal peroxides was also found in this organism. Plakortolides B [6] and D [8], and epiplakinic acid E methyl ester [9], were evaluated for biological activity and found to show cytotoxicity against the A549 human lung carcinoma and P388 murine leukemia cell lines, and to effect adhesion in an assay employing the EL-4.IL-2 cell line, which correlates with signal transduction activity.
Collimation Sensing With Differential Grating and Talbot Interferometry (2014)

The collimation of monochromatic light in optical metrology is of great importance for its determination of the accuracy of physical measurement. This paper proposes a novel collimation testing method with the differential grating (DG) characterized by its high sensitivity. In the process of measurement, the monochromatic light is incident upon a linear grating and is then projected onto a DG to create two sets of linear moiré fringes. By analyzing the relationship between the phase of moiré fringes and the divergence or convergence angle, the collimation of monochromatic light can be easily measured. Compared with the traditional collimation methods, this method is more accurate with an experimental accuracy of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-7</sup> rad , which is in good agreement with the theoretical prediction.
The Impact of Digital Self-Scheduling on No-Show Event Rates in Outpatient Clinics (2020)

The failure of patients to keep scheduled appointments results in significant loss of revenue due to decreased administrative efficiency, expensive clinical resource time, disruptive continuity of care between the patient and the provider, and reduced quality of care. The purpose of this quantitative study was to explore the use of digital self-scheduling as an emerging alternative to traditional office-assisted scheduling methods and determine if its use has an impact on reducing the occurrence of no-show events. The theoretical framework used for the study was the Consumer Behavior Theory. Three years of de-identified secondary data were collected from a large, adult primary care clinic, part of an integrated academic health system in the northeastern United States, in order to probe differences in the clinic’s no-show rates, before and after the implementation of digital self-scheduling. Using chi-square tests for independence, the study revealed a decrease in the no-show rate after digital self-scheduling was implemented. In addition, the no-show rate was lower for appointments that were scheduled using digital self-scheduling versus appointments that were scheduled using traditional office-assisted scheduling. The result of this study contributes to positive social change by acknowledging that patients are consumers who thrive on the digital convenience that they already experience in their daily lives and contributes to enhancing patient and provider communications. The use of digital self-scheduling and other digital transformation tools contributes to the holistic improvement of the patient experience and in increasing provider and care setting support staff satisfaction.
Segmentation and Tracking of Coronary Artery Using Graph-Cut in CT Angiographic (2009)

This paper presents a semiautomatic method to detect the coronary arteries in X-ray CT angiography (CTA) images with simple user interaction. The algorithm is started with performing modified Otsu threshold method and clustering of superpixel to reconstruct the image. The interactive graph cut segmentation and an improved top-hat filter is used to extract the coronary artery in series of two dimension (2D) slice images. Finally, coronary artery tree is tracked with a method based on region average shift. The accuracy of coronary artery extraction has been validated in 16 CTA datasets. The results demonstrate this algorithm has satisfactory speed and efficiency. With more user interaction, the method can be easily extended to the arteries that are not detected automatically.
A Bayesian Approach to Unsupervised One-Shot Learning of Object Categories (2003)

Learning visual models of object categories notoriously requires thousands of training examples; this is due to the diversity and richness of object appearance which requires models containing hundreds of parameters. We present a method for learning object categories from just a few images ( � �). It is based on incorporating “generic” knowledge which may be obtained from previously learnt models of unrelated categories. We operate in a variational Bayesian framework: object categories are represented by probabilistic models, and “prior ” knowledge is represented as a probability density function on the parameters of these models. The “posterior ” model for an object category is obtained by updating the prior in the light of one or more observations. Our ideas are demonstrated on four diverse categories (human faces, airplanes, motorcycles, spotted cats). Initially three categories are learnt from hundreds of training examples, and a “prior ” is estimated from these. Then the model of the fourth category is learnt from 1 to 5 training examples, and is used for detecting new exemplars a set of test images. 1.