gebhart/patrepeval huggingface dataset:
Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis of bleeding and thrombotic diseases (2005)

Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis Platelet-mediated primary haemostasis and blood coagulation have evolved as important defence mechanisms against bleeding. The formation of the platelet plug provides the initial occlusion of the vascular lesion. This is temporally co-ordinated with the activation of the coagulation system, which occurs in response to the rupture of endothelium and the exposure of blood to the extravascular tissue. The reactions of blood coagulation are carefully controlled by several anticoagulant mechanisms and under normal conditions they prevail over the procoagulant forces. Genetic or acquired disturbances of the natural balance between the pro- and anticoagulant systems may result in bleeding or thrombotic diseases.
"On the Fly" Stratigraphic Basin Modelling From Seismic Interpretation Workstations (2005)

Abstract Seismic intepreters already use the principles of sequence stratigraphy to help interpret the geometry and sedimentary facies of the sedimentary bodies seen on seismic data. Linking seismic interpretation to a well database containing information on bathymetry and lithology, by using ultra-rapid algorithms simulating sediment transport, can help the interpreter to rapidly test and modify the stratigraphic scenario inherently present in the geometry and nature of the surfaces that have been picked. This "on the fly" stratigraphic modelling should make seismic stratigraphic interpretation easier and simpler to perform. Various image-processing techniques can also be of help to the interpreter, both in determining depositional environment from seismic textural analysis and in a more rapid identification of the key toplap, onlap, downlap and truncation surfaces present in the seismic data. Again, linking the textural information with the well database can lead to a better use of both types of data. The above techniques have been applied to seismic and well data of the National Petroleum Reserve Alaska, as a structured workflow involving the construction of a detailed geomodel and time-to-depth conversion cube. For each of the sequences picked on the seismic, the direction and composition of the principal sources of clastic supply are determined, and paleobathymetrical maps are generated, all of which are coherent with the well data (interpreted lithology and depositional environment) and the picked thickness of the sequence on seismic. The interpreter can then choose to view the seismic data of the next sequence in «true stratigraphic position» by shearing to fit the modelled bathymetrical profile of the underlying sequence. He or she may also choose to review and reinterpret the well data or repick the seismic surfaces in the light of the realistic paleogeographical scenario generated by the stratigraphic modelling. Introduction The aim of the present work was to test the application of algorithms designed to assist seismic interpretation for petroleum exploration by using the principles of forward stratigraphic basin modelling. We used a data set from the North Slope, Alaska which is freely available online from the United States Geological Survey (see below). The data to be fitted by the stratigraphic forward modelling included the thickness of stratigraphic intervals between markers picked on seismic data, the bathymetry and the lithological content of these interval identified in wells.
Coccoid forms of Helicobacter pylori are the morphologic manifestation of cell death (1997)

Helicobacter pylori can transform from its normal helical bacillary morphology to a coccoid morphology. Since this coccoid form cannot be cultured in vitro, it has been speculated that it is a dormant form potentially involved in the transmission of H. pylori and in a patient's relapse after antibiotic therapy. In this study we determined the effects of aging, temperature, aerobiosis, starvation, and antibiotics on the morphologic conversion rate and culturability of H. pylori. Aerobiosis and the addition of a bactericidal antibiotic to the culture medium resulted in the highest conversion rate. During the conversion to coccoid forms, the cultures always lost culturability at the stage where 50% of the organisms were still in bacillary form; this result indicated that culturability and coccoid morphology are two separate but related entities. Independent of the conditions used to induce the conversion into coccoids, the morphological conversion was accompanied by several marked antigenic and ultrastructural changes. Also, both the total amounts and the integrity of RNA and DNA were significantly reduced in coccoid forms. With the potential-sensitive probe diOC(5)-3, a clear loss of membrane potential in coccoid forms was observed. Inhibition of protein or RNA synthesis by the addition of bacteriostatic antibiotics did not prevent the conversion to coccoid forms but resulted in an increased conversion rate. Hence, we conclude that conversion of H. pylori from the bacillary to the coccoid form is a passive process that does not require protein synthesis. Our data suggest that the coccoid form of H. pylori is the morphologic manifestation of bacterial cell death.
Implied Volatility Functions: Empirical Tests (1998)

Derman and Kani (1994), Dupire (1994), and Rubinstein (1994) hypothesize that asset return volatility is a deterministic function of asset price and time, and develop a deterministic volatility function (DVF) option valuation model that has the potential of fitting the observed cross section of option prices exactly. Using S&P 500 options from June 1988 through December 1993, we examine the predictive and hedging performance of the DVF option valuation model and find it is no better than an ad hoc procedure that merely smooths Black–Scholes (1973) implied volatilities across exercise prices and times to expiration.
Advances in free flap monitoring: have we gone too far? (2009)

We provide an overview of recent techniques for free flap monitoring. No single technique provides an ideal method for free flap monitoring, but these methods may prove promising with future research and refinement. New techniques in free flap monitoring largely remain out of the scope of reasonable implementation.
Developing a more comprehensive and expressive SOA governance framework (2010)

Many companies have adopted Service-Oriented Architecture (SOA) as an approach to improve agility and increase performance of system development. However, deploying SOA has been encountered with some challenges and problems such as service funding, service ownership and standards compliance for years. Therefore, to address SOA challenges, organizations require a comprehensive and applicable SOA governance framework to implement management and control mechanisms. A number of SOA governance frameworks have been proposed by researchers and practitioners. The scope and coverage of these frameworks differ extensively. Nevertheless, they do not completely document SOA processes, governance procedures and SOA roadmap, and also they do not cover all important elements of SOA governance. In this paper, in the process of proposing a new SOA governance framework, a set of important elements for a desired SOA governance framework have been proposed. Based on these elements, a more comprehensive and expressive framework is developed with focus on covering SOA governance elements and documenting SOA processes and activities, defining control as the policies and procedures embedded in each process and providing metrics and maturity model. The proposed framework is obtained by extending characteristics of COBIT framework to cover and support the SOA principles and requirements.
Selecting an antidepressant by using mechanism of action to enhance efficacy and avoid side effects. (1998)

The diversity of antidepressant mechanisms available today allows clinicians to individualize treatment decisions for depressive symptoms and subtypes, as well as to avoid side effects. The mechanism of action of antidepressants allows prediction of both adverse effects and therapeutic effects. Individual antidepressants have unique psychopharmacologic profiles, and individual patients have unique clinical profiles of different symptoms and depressive subtypes. By using this knowledge, the prescriber can match drug profiles with patient profiles to select preferred agents and avoid less preferred agents.
Application of fused deposition in controlled microstructure metal‐ceramic composites (2006)

Purpose Al‐alumina interconnected phase composites were processed using the direct fused deposition process. These materials with tailored microstructures can find applications as structural materials with gradient properties. Design/methodology/approach In this process, feedstock material with fused silica as a starting material was compounded at a high shear mixer and then extruded as a filament using a single screw extruder. Extruded filaments were used with a commercial fused deposition modeler, FDM 1650, to process controlled porosity green ceramic structures. Porous green ceramic preforms were subjected to binder removal and sintering cycles in furnace air. Controlled porosity sintered ceramic structures were infiltrated with Al 5052 metal by pressureless reactive metal infiltration to form an in situ Al‐alumina structured composite. Findings The main advantage for this approach is to control distribution of both metal and ceramic phases in the composite. During metal infiltration good bonding was observed between the metal and the ceramic phases. Composites were tested under both quasi‐static and dynamic shock loading to evaluate their mechanical properties. Compression strength of these composites was 689±95 MPa. Originality/value This paper describes application of the direct fused deposition process for fabrication of ceramic/metal composites where both macrostructure as well as microstructure can be controlled simultaneously. The paper also focuses on one of the potential application area for 5052‐Al alloy.
Rapid Polymer Identification by In-Source Direct Pyrolysis Mass Spectrometry and Library Searching Techniques (1996)

In-source direct pyrolysis mass spectrometry is studied for rapid identification of polymers in industrial products. In this technique, polymers are pyrolyzed within the ion source of a mass spectrometer by a coiled filament designed for desorption chemical ionization/desorption electron ionization applications. Pyrolysis products are ionized by 70 eV electron impact, yielding highly reproducible mass spectra characteristic of the polymer composition. Using this technique and a commercial library editor, a comprehensive mass spectral library containing more than 150 polymer entries was developed. The impacts of experimental and polymer variables on the reproducibility of polymer mass spectra were evaluated. The technique was successfully applied to the analysis of polymers in industrial products, showing advantages of short analysis time, high confidence level, and low matrix interference. This study suggests that a robust standard polymer library, independent of laboratory and mass spectrometer type, may be developed. However, more rigorous interlaboratory tests are needed to achieve this goal.
Mistuning of Bladed Disk Assemblies to Mitigate Resonance (2006)

Bladed disks are mistuned in general. Their forced vibration response at resonance can be much higher thanthetunedbladeresponse.Themagnificationofforcedresponseoverthetunedcasecanbeunderstood by frequency split that takes place and modal distortion. In this paper, modal distortion technique is adopted to minimize the mistuning effects and control resonant response.
Reviews (1966)

Journal Article Reviews Get access Statistical Method in Biological Assay. 2nd edition. BY D. J. FINNEY . London: Charles Griffin and Co. 1964. Pp. 668. £5. 5s. D. E. BARTON D. E. BARTON Search for other works by this author on: Oxford Academic Google Scholar Biometrika, Volume 53, Issue 1-2, June 1966, Pages 301–302, https://doi.org/10.1093/biomet/53.1-2.301-a Published: 01 June 1966
Multi-mode Access System with Anchor Layer 2/3 Protocol for Beyond 3G Wireless Networks (2006)

In this paper, we introduce a new multi-mode Beyond 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> Generation (B3G) access system concept based on heterogeneous physical layer modes or configurations, with a common (or anchor) layer 2 and 3 protocols stack. Such a system can support a wide variety of physical layer access techniques, e.g. Code Division Multiple Access (CDMA), Orthogonal Frequency Division Multiple Access (OFDMA), Multi-Carrier CDMA (MC-CDMA) etc, with different configurations which are optimized for different deployment scenarios and performance targets, while anchored by a common layer 2 and 3 protocols. Seamless inter-system handoff is enabled by the common layer 2/3 protocols, while dynamic radio resource/load/spectrum management can be performed across the different physical layer modes to achieve optimum spectrum efficiency and Quality of Service (QoS) support. The overall system concept of the multimode access system is first presented, followed by a detailed account of the anchor layer 2/3 protocol design.
Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates (2007)

Our findings show that (a) molecular evolution of paralogs correlates with their expression pattern; (b) gene diversification is obtained through massive genomic rearrangements; and (c) splicing modification contributes to the functional specialization of novel genes.
Multi-layer architecture for realization of network virtualization using MPLS technology (2016)

Network virtualization (NV) increases Internet flexibility by separating policies from mechanisms. This makes developing new applications, managing the Internet, and supporting different applications much easier. In this study, we introduce a multi-layer architecture which combines multi-level multiprotocol label switching (MPLS) technology with NV. The proposed architecture combines the high speed advantage of MPLS with the high flexibility of NV. We use MPLS in MPLS technique and encapsulate each MPLS packet within another when it encounters a new virtual network. Our architecture has the potential to improve Internet flexibility and pave the way for deployment and commercialization of NV in next generation networks.
Programmable polarization-independent spectral phase compensation and pulse shaping (2003)

We report the first use of a double-layer liquid crystal modulator array for spectral phase pulse shaping that operates independent of polarization. Such insensitivity to polarization is crucial for fiber applications, e.g., dispersion compensation.
Telithromycin Is Active against <i>Mycobacterium avium</i> in Mice despite Lacking Significant Activity in Standard In Vitro and Macrophage Assays and Is Associated with Low Frequency of Resistance during Treatment (2001)

ABSTRACT The activity of telithromycin, a new ketolide, was evaluated in vitro and in vivo against Mycobacterium avium complex (MAC) strains. The MIC of telithromycin for several M. avium isolates obtained from the blood of AIDS patients ranged from 16 to >128 μg/ml (MIC at which 90% of isolates are inhibited, >128 μg/ml), and the compound did show activity in the macrophage system at concentrations greater than 8 or 16 μg/ml, but this was dependent on the MAC strain used. Telithromycin was then administered to mice infected with MAC strain 101 for 4 weeks at doses of 100, 200, or 400 mg/kg of body weight/day. Treatment with 100 and 200 mg/kg/day was bacteriostatic, but at 400 mg/kg/day telithromycin was bactericidal for MAC strains. The frequency of the emergence of resistance to telithromycin was low despite prolonged usage (12 weeks). This study demonstrates that telithromycin is active in vivo against MAC and warrants further evaluation.
<b>The Pentalenyl Dianion</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Pentalenyl DianionThomas J. Katz and Michael. RosenbergerCite this: J. Am. Chem. Soc. 1962, 84, 5, 865–866Publication Date (Print):March 1, 1962Publication History Published online1 May 2002Published inissue 1 March 1962https://pubs.acs.org/doi/10.1021/ja00864a038https://doi.org/10.1021/ja00864a038research-articleACS PublicationsRequest reuse permissionsArticle Views397Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chinese Zero Pronoun Resolution with Deep Neural Networks (2016)

While unsupervised anaphoric zero pronoun (AZP) resolvers have recently been shown to rival their supervised counterparts in performance, it is relatively difficult to scale them up to reach the next level of performance due to the large amount of feature engineering efforts involved and their ineffectiveness in exploiting lexical features. To address these weaknesses, we propose a supervised approach to AZP resolution based on deep neural networks, taking advantage of their ability to learn useful task-specific representations and effectively exploit lexical features via word embeddings. Our approach achieves stateof-the-art performance when resolving the Chinese AZPs in the OntoNotes corpus.
Method of Load/Fault Detection for Loosely Coupled Planar Wireless Power Transfer System With Power Delivery Tracking (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A method to determine various operating modes of a high-efficiency inductive wireless power transfer system which is capable of supporting more than one receiver is proposed. The three operating modes are <emphasis emphasistype="boldital">no-load</emphasis>, <emphasis emphasistype="boldital">safe</emphasis>, and <emphasis emphasistype="boldital">fault</emphasis> modes. The detection scheme probes the transmitter circuitry periodically to determine the operating mode. For power saving, the transmitter is powered down when there is no valid receiver placed on the transmitting coil. If any conductive or magnetic object that can affect the total effective inductance of the transmitting coil is located nearby, the system will enter the <emphasis emphasistype="boldital">fault</emphasis> mode and shut down the transmitter so that it will not be damaged. The <emphasis emphasistype="boldital">safe</emphasis> mode is the nominal operation mode when the power transmission efficiency is high with minimum power loss and zero-voltage switching operation of the class-E transmitter is achieved. The determination of the operating mode is achieved by analyzing the transmitting coil voltage and supply current space, requiring no communication link between the transmitter and receiver. The linear relationship between the power delivery and the supply current can be used to calculate the power delivered to the load(s). </para>
SNPstream <sup>®</sup> UHT: Ultra-High Throughput SNP Genotyping for Pharmacogenomics and Drug Discovery (2002)

Single nucleotide polymorphism (SNP) genotyping is playing an increasing role in genome mapping, pharmacogenetic studies, and drug discovery. To date, genome-wide scans and studies involving thousands of SNPs and samples have been hampered by the lack of a system that can perform genotyping with cost-effective throughput, accuracy, and reliability. To address this need, Orchid has developed an automated, ultra-high throughput system, SNPstream® UHT, which uses multiplexed PCR in conjunction with our next generation SNP-IT™ tag array single base extension genotyping technology. The system employs oligonucleotide microarrays manufactured in a 384-well format on a novel glass-bottomed plate. Multiplexed PCR and genotyping are performed in homogeneous reactions, and assay results are read by direct two-color fluorescence on the SNPstream UHT Array Imager. The system’s flexibility enables large projects involving thousands of SNPs and thousands of samples as well as small projects that have hundreds of SNPs and hundreds of samples to be done cost effectively. We have successfully demonstrated this system in greater than 1 000 000 genotyping assays with >96% of samples giving genotypes with >99% accuracy.
The Endocrine Activities of 8-Prenylnaringenin and Related Hop (<i>Humulus lupulus</i>L.) Flavonoids (2000)

The female flowers of the hop plant have long been used as a preservative and a flavoring agent in beer, but they are now being included in some herbal preparations for women for "breast enhancement." This study investigated the relative estrogenic, androgenic and progestogenic activities of the known phytoestrogen, 8-prenylnaringenin, and structurally related hop flavonoids. 6-Prenylnaringenin, 6,8-diprenylnaringenin and 8-geranylnaringenin exhibited some estrogenicity, but their potency was less than 1% of that of 8-prenylnaringenin. 8-Prenylnaringenin alone competed strongly with 17ss-estradiol for binding to both the alpha- and ss-estrogen receptors. None of the compounds (xanthohumol, isoxanthohumol, 8-prenyl-naringenin, 6-prenylnaringenin, 3'-geranylchalconaringenin, 6-geranylnaringenin, 8-geranylnaringenin, 4'-O:-methyl-3'-prenylchalconaringenin and 6,8-diprenylnaringenin) nor polyphenolic hop extracts showed progestogenic or androgenic bioactivity. These results indicate that the endocrine properties of hops and hop products are due to the very high estrogenic activity of 8-prenylnaringenin and concern must be expressed about the unrestricted use of hops in herbal preparations for women.