gebhart/patrepeval huggingface dataset:
Spacecraft studies of planetary surfaces using bistatic radar (1993)

Spaceborne transmitters have been used in bistatic geometries for a number of planetary surface studies including inference of topography, Fresnel reflectivity, and RMS surface slopes on the Moon, Mars, and Venus. For the Moon and Mars in particular, the bistatic geometry has enabled remote probing in regions and under conditions not obtainable with Earth-based radar systems, yielding information about surface characteristics and properties on scales of centimeters to hundreds of meters that complements monostatic radar observations. A new generation of planetary spacecraft now provides opportunities for further experiments, including more nearly complete definition of the surface scattering function and, possibly, imaging. Targets of interest include the polar regions of Venus (by Magellan) and Mars (by Mars Observer), the enigmatic icy Galilean satellites of Jupiter (by Galileo), and Saturn's largest moon Titan (by Cassini).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Prioritizing Warning Categories by Analyzing Software History (2007)

Automatic bug finding tools tend to have high false positive rates: most warnings do not indicate real bugs. Usually bug finding tools prioritize each warning category. For example, the priority of "overflow " is 1 and the priority of "jumbled incremental" is 3, but the tools 'prioritization is not very effective. In this paper, we prioritize warning categories by analyzing the software change history. The underlying intuition is that if warnings from a category are resolved quickly by developers, the warnings in the category are important. Experiments with three bug finding tools (FindBugs, JLint, and PMD) and two open source projects (Columba and jEdit) indicate that different warning categories have very different lifetimes. Based on that observation, we propose a preliminary algorithm for warning category prioritizing.
ENGINE, BATTERY AND VEHICLE SIMULATION STRATEGIES FOR TRANSMISSION TESTING (2024)

<title>WHY DO WE NEED SIMULATIONS?</title> <p>This paper is intended to provide a broad presentation of the simulation techniques focusing on transmission testing touching a bit on power train testing. Often, we do not have the engine or vehicle to run live proving ground tests on the transmission. By simulating the vehicle and engine, we reduce the overall development time of a new transmission design. For HEV transmissions, the battery may not be available. However, the customer may want to run durability tests on the HEV motor and/or the electronic control module for the HEV motor. What-if scenarios that were created using software simulators can be verified on the test stand using the real transmission. NVH applications may prefer to use an electric motor for engine simulation to reduce the engine noise level in the test cell so transmission noise is more easily discernable.</p>
New field integration frequency interleaving color television pickup system for single-chip CCD camera (1985)

A new field integration frequency interleaving color-television pickup system has been developed for a single-chip CCD color video camera. This system uses anew color filter array, comprising a plurality of unit filter arrays, each unit consisting of 2 × 4 filter elements of yellow, cyan, and green color. High color fidelity and high-resolution color pictures without frame integration lag were obtained using only a ½-inch interline transfer CCD having 500 × 400 picture elements.
Synthesis and Biological Activity of the Novel Adenosine Analogs; 3-Amino-6-(β-D-ribofuranosyl)pyrazolo[3,4-<i>c</i>]pyrazole and 3-Amino-1-methyl-6-(β-D-ribofuranosyl)pyrazolo[3,4-<i>c</i>]pyrazole (1994)

Abstract Chemical modification of the 4-nitrile group in 5-amino-1-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrazole-4-carbonitrile (1) afforded 5-amino-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1-(2,3,5-tri-O-benzyl-β-D-ribofuran osyl)pyrazole (3). The methylation of 3, via a three step procedure, gave 5-methylamino-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrazole (3a). The mononuclear heterocyclic rearrangement (m.h.r) of 3 and 3a, provided a convenient route to the novel azapentalene adenosine analogs 3-amino-6-(β-D-ribofuranosyl)pyrazolo[3,4-c]pyrazole (6) and 3-amino-1-methyl-6-(β-D-ribofuranosyl)pyrazolo[3,4-c]pyrazole (6a), respectively. Compound 6 exhibited no cytotoxicity when screened in vitro against either mouse L1210 leukemic cells or human foreskin fibroblasts. Nor was it active against human cytomegalovirus. Compound 6a was designed and prepared to investigate the possibility that the lack of biological activity of 6 might be due to annular tautomerization limiting the ability of 6 to serve as a substrate for the activating enzyme adenosine kinase. This hypothesis was neither supported nor disproved by the results, as compound 6a was also inactive in both the antiproliferative and antiviral test systems.
Effect of ω-trifluorination on the microsomal metabolism of ethyl and pent-1-yl<i>p</i>-nitrophenyl ether (1986)

p-Nitrophenyl pent-1-yl ether was metabolized (65-70%) in the presence of liver microsomes from phenobarbital-treated rats to give the 4-(major), 3-(minor), and 2-hydroxypent-1-yl (minor) derivatives which were characterized by g.l.c.-mass spectrometry; O-dealkylation (reflecting 1-hydroxylation) and 5-hydroxylation did not occur to a significant extent. 5,5,5-Trifluorination of the pent-1-yl group markedly reduced the extent of metabolism (to approximately 10%). p-Nitrophenyl 2,2,2-trifluoroethyl ether was virtually completely resistant to microsomal metabolism under conditions where the ethyl analogue was extensively O-dealkylated.
Implementing A Unique Chip Id On A Reconfigurable Polymorphic Circuit (2013)

A unique unclonable chip ID has been implemented using various platforms in the recent years. In this paper, we investigate the use of polymorphic gates as a new mechanism for implementing a unique chip ID in systems already containing some polymorphic gates. The proposed solution exploits the fact that switching time of polymorphic gates (controlled by Vdd) is slightly different even for neighboring gates on the same die because of fabrication variations. We applied a partial reconfiguration in order to generate 48-bit IDs on the reconfigurable polymorphic REPOMO32 chip that we have developed in our previous research. We achieved 94.44% stable bits which is reasonably close to existing approaches.DOI: http://dx.doi.org/10.5755/j01.itc.42.1.925
Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling (2014)

Histone H3 lysine(27)-to-methionine (H3K27M) gain-of-function mutations occur in highly aggressive pediatric gliomas. We established a Drosophila animal model for the pathogenic histone H3K27M mutation and show that its overexpression resembles polycomb repressive complex 2 (PRC2) loss-of-function phenotypes, causing derepression of PRC2 target genes and developmental perturbations. Similarly, an H3K9M mutant depletes H3K9 methylation levels and suppresses position-effect variegation in various Drosophila tissues. The histone H3K9 demethylase KDM3B/JHDM2 associates with H3K9M-containing nucleosomes, and its misregulation in Drosophila results in changes of H3K9 methylation levels and heterochromatic silencing defects. We have established histone lysine-to-methionine mutants as robust in vivo tools for inhibiting methylation pathways that also function as biochemical reagents for capturing site-specific histone-modifying enzymes, thus providing molecular insight into chromatin signaling pathways.
Linking novelty seeking and harm avoidance personality traits to cerebellar volumes (2012)

Personality traits are multidimensional traits comprising cognitive, emotional, and behavioral characteristics, and a wide array of cerebral structures mediate individual variability. Differences in personality traits covary with brain morphometry in specific brain regions, and neuroimaging studies showed structural or functional abnormalities of cerebellum in subjects with personality disorders, suggesting a cerebellar role in affective processing and an effect on personality characteristics. To test the hypothesis that cerebellar [white matter (WM) and cortex] volumes are correlated with scores obtained in the four temperamental scales of the Temperament and Character Inventory (TCI) by Cloninger, a total of 125 healthy participants aged 18-67 years of both genders (males = 52) completed the TCI and underwent magnetic resonance imaging. The scores obtained in each temperamental scale were associated with the volumes of cerebellar WM and cortex of right and left hemispheres separately by using linear regression analyses. In line with our hypothesis, novelty seeking (NS) scores were positively associated with WM and cortex cerebellar volumes. Harm avoidance (HA) scores were negatively associated with WM and cortex cerebellar volumes. The range of individual differences in NS and HA scores reflects the range of variances of cerebellar volumes. The present data indicating a cerebellar substrate for some personality traits extend the relationship between personality and brain areas to a structure up to now thought to be involved mainly in motor and cognitive functions, much less in emotional processes and even less in personality individual differences.
Radiation injury and neurogenesis (2003)

Purpose of review For many cancers, survival depends on aggressive combined therapies, but treatment comes at a price. Children and adults who receive radiotherapy involving the brain frequently experience a progressive cognitive decline. The overt pathologies of radiation injury such as white matter necrosis or vasculopathy are the obvious ‘smoking guns’ of dysfunction. However, many patients exhibit severe learning and memory deficits with no overt pathologic changes. This is especially true when the radiation field involves the temporal lobes. The cause of this debilitating dysfunction is currently unknown and untreatable. Recent findings Within the temporal lobe, the hippocampal formation plays a central role in short-term learning and memory - the functions most notably affected by radiation. Recent work has also shown that hippocampus-dependent learning and memory are strongly influenced by the activity of neural stem cells and their proliferative progeny. The hippocampal granule cell layer undergoes continuous renewal and restructuring by the addition of new neurons. Radiation at much lower doses than that needed to injure the more resistant post-mitotic neurons and glia of the brain has been found to affect these highly proliferative progenitors severely. The stem/progenitor cell is so sensitive to radiation that a single low dose to the cranium of a mature rat is sufficient to ablate hippocampal neurogenesis. Summary Progressive learning and memory deficits following irradiation may be caused by the accumulating hippocampal dysfunction that results from a long-term absence of normal stem/progenitor activity. Here, the authors describe the nature of this stem cell dysfunction and contemplate how restoration of stem/progenitor cell activity might be approached in experimental models and, eventually, the clinic.
Hyperspectral material identification on radiance data using single-atmosphere or multiple-atmosphere modeling (2010)

Reflectance-domain methods convert hyperspectral data from radiance to reflectance using an atmospheric compensation model. Material detection and identification are performed by comparing the compensated data to target reflectance spectra. We introduce two radiance-domain approaches, Single atmosphere Adaptive Cosine Estimator (SACE) and Multiple atmosphere ACE (MACE) in which the target reflectance spectra are instead converted into sensor-reaching radiance using physics-based models. For SACE, known illumination and atmospheric conditions are incorporated in a single atmospheric model. For MACE the conditions are unknown so the algorithm uses many atmospheric models to cover the range of environmental variability, and it approximates the result using a subspace model. This approach is sometimes called the invariant method, and requires the choice of a subspace dimension for the model. We compare these two radiance-domain approaches to a Reflectance-domain ACE (RACE) approach on a HYDICE image featuring concealed materials. All three algorithms use the ACE detector, and all three techniques are able to detect most of the hidden materials in the imagery. For MACE we observe a strong dependence on the choice of the material subspace dimension. Increasing this value can lead to a decline in performance.
Left Ventricular and Myocardial Perfusion Responses to Volume Unloading and Afterload Reduction in a Computer Simulation (2004)

Ventricular assist devices (VADs) have been used successfully as a bridge to transplant in heart failure patients by unloading ventricular volume and restoring the circulation. In a few cases, patients have been successfully weaned from these devices after myocardial recovery. To promote myocardial recovery and alleviate the demand for donor organs, we are developing an artificial vasculature device (AVD) that is designed to allow the heart to fill to its normal volume but eject against a lower afterload. Using this approach, the heart ejects its stroke volume (SV) into an AVD anastomosed to the aortic arch, which has been programmed to produce any desired afterload condition defined by an input impedance profile. During diastole, the AVD returns this SV to the aorta, providing counterpulsation. Dynamic computer models of each of the assist devices (AVD, continuous, and pulsatile flow pumps) were developed and coupled to a model of the cardiovascular system. Computer simulations of these assist techniques were conducted to predict physiologic responses. Hemodynamic parameters, ventricular pressure-volume loops, and vascular impedance characteristics were calculated with AVD, continuous VAD, and asynchronous pulsatile VAD support for a range of clinical cardiac conditions (normal, failing, and recovering left ventricle). These simulation results indicate that the AVD may provide better coronary perfusion, as well as lower vascular resistance and elastance seen by the native heart during ejection compared with continuous and pulsatile VAD. Our working hypothesis is that by controlling afterload using the AVD approach, ventricular cannulation can be eliminated, myocardial perfusion improved, myocardial compliance and resistance restored, and effective weaning protocols developed that promote myocardial recovery.
Exploiting path diversity in Content Delivery Network with the collaboration of SDN (2017)

Content Delivery Networks (CDNs) are able to improve user-oriented application performance through caching and anycast routing or DNS-based user mapping mechanism. With the fact that BGP is widely used for inter autonomous system (AS) routing for CDNs, there is a middle mile bottleneck problem, which cause by the nature limitation of BGP. To solve this problem, we propose an SDN-based tunnel multi-path system, CDN-Detour, which can detour the bottleneck for CDN to improve user experience.
Screening, Nucleotide Sequence, and Biochemical Characterization of an Esterase from <i>Pseudomonas fluorescens</i> with High Activity towards Lactones (1999)

A genomic library of Pseudomonas fluorescens DSM 50106 in a lambdaRESIII phage vector was screened in Escherichia coli K-12 for esterase activity by using alpha-naphthyl acetate and Fast Blue RR. A 3.2-kb DNA fragment was subcloned from an esterase-positive clone and completely sequenced. Esterase EstF1 was encoded by a 999-bp open reading frame (ORF) and exhibited significant amino acid sequence identity with members of the serine hydrolase family. The deduced amino acid sequences of two other C-terminal truncated ORFs exhibited homology to a cyclohexanone monooxygenase and an alkane hydroxylase. However, esterase activity was not induced by growing of P. fluorescens DSM 50106 in the presence of several cyclic ketones. The esterase gene was fused to a His tag and expressed in E. coli. The gene product was purified by zinc ion affinity chromatography and characterized. Detergents had to be added for purification, indicating that the enzyme was membrane bound or membrane associated. The optimum pH of the purified enzyme was 7.5, and the optimum temperature was 43 degreesC. The showed highest purified enzyme activities towards lactones. The activity increased from gamma-butyrolactone (18.1 U/mg) to epsilon-caprolactone (21.8 U/mg) to delta-valerolactone (36.5 U/mg). The activities towards the aliphatic esters were significantly lower; the only exception was the activity toward ethyl caprylate, which was the preferred substrate.
Equine major histocompatibility complex class I molecules act as entry receptors that bind to equine herpesvirus-1 glycoprotein D (2011)

The endotheliotropism of equine herpesvirus-1 (EHV-1) leads to encephalomyelitis secondary to vasculitis and thrombosis in the infected horse central nervous system (CNS). To identify the host factors involved in EHV-1 infection of CNS endothelial cells, we performed functional cloning using an equine brain microvascular endothelial cell cDNA library. Exogenous expression of equine major histocompatibility complex (MHC) class I heavy chain genes conferred susceptibility to EHV-1 infection in mouse NIH3T3 cells, which are not naturally susceptible to EHV-1 infection. Equine MHC class I molecules bound to EHV-1 glycoprotein D (gD), and both anti-gD antibodies and a soluble form of gD blocked viral entry into NIH3T3 cells stably expressing the equine MHC class I heavy chain gene (3T3-A68 cells). Treatment with an anti-equine MHC class I monoclonal antibody blocked EHV-1 entry into 3T3-A68 cells, equine dermis (E. Derm) cells and equine brain microvascular endothelial cells. In addition, inhibition of cell surface expression of MHC class I molecules in E. Derm cells drastically reduced their susceptibility to EHV-1 infection. These results suggest that equine MHC class I is a functional gD receptor that plays a pivotal role in EHV-1 entry into equine cells.
Ionic Liquids Containing the Tris(pentafluoroethyl)trifluorophosphate Anion: a New Class of Highly Selective and Ultra Hydrophobic Solvents for the Extraction of Polycyclic Aromatic Hydrocarbons Using Single Drop Microextraction (2009)

A new class of ionic liquids (ILs) containing the tris(pentafluoroethyl)trifluorophosphate (FAP) anion are paired with imidazolium, phosphonium, and pyrrolidinium cations and used as extraction solvents in direct immersion single drop microextraction (SDME) studies coupled to high performance liquid chromatography (HPLC). The selectivity and sensitivity of the extraction method can be tuned and manipulated by varying the cationic component of the IL, thereby providing larger enrichment factors for a variety of analytes, including polycyclic aromatic hydrocarbons (PAHs). Compared to other hydrophobic ILs containing the hexafluorophosphate (PF(6)(-)) and bis[(trifluoromethyl)sulfonyl]imide (NTf(2)(-)) anions, FAP-based ILs are significantly more hydrophobic and hydrolytically stable permitting them to be used in the sampling of large volumes of aqueous solutions without dissolution or loss of the IL. The highest enrichment factors were obtained with the trihexyl(tetradecyl)phosphonium FAP ([PH(3)T] [FAP]) IL for compounds with high molecular weight and fused rings while high enrichment factors were obtained for smaller, more polar molecules using the 1-hexyl-3-methylimidazolium FAP ([HMIM] [FAP]) IL. The detection limits for nine studied PAHs ranged from 0.1 to 0.6, 0.03 to 0.4, 0.04 to 0.7 and 0.1 to 1.2 microg L(-1) for [HMIM] [FAP], [PH(3)T] [FAP], 1-butyl-1-methylpyrrolidinium FAP ([BMPL] [FAP]), and 1-(6-amino-hexyl)-1-methylpyrrolidinium FAP ([HNH(2)MPL] [FAP]), respectively. The reproducibility of the extraction method at 20 degrees C using the FAP-based ILs was in the range of 1.5-9.4%. Three real water samples including tap water, creek water, and river water were analyzed and yielded recoveries ranging from 79-114%.
Holographic mode generation for mode division multiplexing (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. Carpenter and T. D. Wilkinson, "Holographic mode generation for mode division multiplexing," in National Fiber Optic Engineers Conference, OSA Technical Digest (Optica Publishing Group, 2012), paper JW2A.42. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Kinetics and Mechanism of Ethanol Dehydration on γ-Al<sub>2</sub>O<sub>3</sub>: The Critical Role of Dimer Inhibition (2013)

Steady state, isotopic, and chemical transient studies of ethanol dehydration on γ-alumina show unimolecular and bimolecular dehydration reactions of ethanol are reversibly inhibited by the formation of ethanol–water dimers at 488 K. Measured rates of ethylene synthesis are independent of ethanol pressure (1.9–7.0 kPa) but decrease with increasing water pressure (0.4–2.2 kPa), reflecting the competitive adsorption of ethanol–water dimers with ethanol monomers; while diethyl ether formation rates have a positive, less than first order dependence on ethanol pressure (0.9–4.7 kPa) and also decrease with water pressure (0.6–2.2 kPa), signifying a competition for active sites between ethanol–water dimers and ethanol dimers. Pyridine inhibits the rate of ethylene and diethyl ether formation to different extents verifying the existence of acidic and nonequivalent active sites for the dehydration reactions. A primary kinetic isotope effect does not occur for diethyl ether synthesis from deuterated ethanol and only occurs for ethylene synthesis when the β-proton is deuterated; demonstrating olefin synthesis is kinetically limited by either the cleavage of a Cβ-H bond or the desorption of water on the γ-alumina surface and ether synthesis is limited by the cleavage of either the C–O bond of the alcohol molecule or the Al–O bond of a surface bound ethoxide species. These observations are consistent with a mechanism inhibited by the formation of dimer species. The proposed model rigorously describes the observed kinetics at this temperature and highlights the fundamental differences between the Lewis acidic γ-alumina and Brønsted acidic zeolite catalysts.