gebhart/patrepeval huggingface dataset:
The mediating role of burnout on the relationship of emotional intelligence and self-efficacy with OCB and performance (2015)

Purpose – This study aims to examined the relationship between emotional intelligence (EI), self-efficacy and two outcome variables: in-role performance and organizational citizenship behavior (OCB). The study also examined whether burnout mediates this relationship. The target population included Arab teachers in Israel. Design/methodology/approach – A survey was performed. Usable questionnaires were returned by 221 teachers; therefore, the response rate was 88 per cent. Findings – Hierarchical linear models and mediation analyses showed that EI and self-efficacy are related to OCB, and in-role performance and burnout have a strong and negative relationship with the outcome variables. Mediation analysis using Preacher and Hayes’s (2004, 2008) approach showed that burnout mediates the relationship of EI and self-efficacy with the three outcome variables. Practical implications – The findings emphasize the role of the two personal variables examined here as important determinants of job performance and OCB, and demonstrate the importance of burnout in understanding OCB. Originality/value – This study will contribute to the literature on OCB and work performance by examining the rarely researched relationships between EI and self-efficacy, on the one hand, and between OCB and in-role performance, on the other. Further, this study will argue that burnout mediates the relationship between these personal and outcome variables.
Syntheses of Furano Compounds : Part XLIV. Syntheses of 2-Carboxybenzo[b]Furan-3-Acetic Acid and 3-Carboxybenzo[b]Furan-2-Acetic Acid (1980)

Department of Chemistry, Patna. University, Patna-5 <em>Manuscript received 6 September 1979, accepted 9 April 1980</em> 2-Carboxybenzo[b]furan-3-acetic acid and 3-carboxybenzo[b]furan-2-acetic acid have been synthesised. A new synthesis of benzo[b]furan-3-acetic acid, a plant hormone is reported.
Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule. (1984)

We have determined the amino acid sequence of the amino-terminal 67,000-dalton (67-kDa) fragment of human ceruloplasmin and have established overlapping sequences between the 67-kDa and 50-kDa fragments and between the 50-kDa and 19-kDa fragments. The 67-kDa fragment contains 480 amino acid residues and three glucosamine oligosaccharides. These results together with our previous sequence data for the 50-kDa and 19-kDa fragments complete the amino acid sequence of human ceruloplasmin. The polypeptide chain has a total of 1,046 amino acid residues (Mr 120,085) and has attachment sites for four glucosamine oligosaccharides; together these account for the total molecular mass of human ceruloplasmin (132 kDa). The sequence analysis of the peptides overlapping the fragments showed that one additional amino acid, arginine, is present between the 67-kDa and 50-kDa fragments, and another, lysine, is between the 50-kDa and 19-kDa fragments. Only two apparent sites of amino acid interchange have been identified in the polypeptide chain. Both involve a single-point interchange of glycine and lysine that would result in a difference in charge. The results of the complete sequence analysis verified that human ceruloplasmin is composed of a single polypeptide chain and that the subunit-like fragments are produced by proteolytic cleavage during purification (and possibly also in vivo).
Spatial four-alternative forced-choice method is the preferred psychophysical method for naive observers (2006)

H. R. Blackwell (1952) investigated the influence of different psychophysical methods and procedures on detection thresholds. He found that the temporal two-interval forced-choice method (2-IFC) combined with feedback, blocked constant stimulus presentation with few different stimulus intensities, and highly trained observers resulted in the "best" threshold estimates. This recommendation is in current practice in many psychophysical laboratories and has entered the psychophysicists' "folk wisdom" of how to run proper psychophysical experiments. However, Blackwell's recommendations explicitly require experienced observers, whereas many psychophysical studies, particularly with children or within a clinical setting, are performed with naïve observers. In a series of psychophysical experiments, we find a striking and consistent discrepancy between naïve observers' behavior and that reported for experienced observers by Blackwell: Naïve observers show the "best" threshold estimates for the spatial four-alternative forced-choice method (4-AFC) and the worst for the commonly employed temporal 2-IFC. We repeated our study with a highly experienced psychophysical observer, and he replicated Blackwell's findings exactly, thus suggesting that it is indeed the difference in psychophysical experience that causes the discrepancy between our findings and those of Blackwell. In addition, we explore the efficiency of different methods and show 4-AFC to be more than 3.5 times more efficient than 2-IFC under realistic conditions. While we have found that 4-AFC consistently gives lower thresholds than 2-IFC in detection tasks, we have found the opposite for discrimination tasks. This discrepancy suggests that there are large extrasensory influences on thresholds--sensory memory for IFC methods and spatial attention for spatial forced-choice methods--that are critical but, alas, not part of theoretical approaches to psychophysics such as signal detection theory.
Differential Privacy-enabled Federated Learning for Sensitive Health Data (2019)

Leveraging real-world health data for machine learning tasks requires addressing many practical challenges, such as distributed data silos, privacy concerns with creating a centralized database from person-specific sensitive data, resource constraints for transferring and integrating data from multiple sites, and risk of a single point of failure. In this paper, we introduce a federated learning framework that can learn a global model from distributed health data held locally at different sites. The framework offers two levels of privacy protection. First, it does not move or share raw data across sites or with a centralized server during the model training process. Second, it uses a differential privacy mechanism to further protect the model from potential privacy attacks. We perform a comprehensive evaluation of our approach on two healthcare applications, using real-world electronic health data of 1 million patients. We demonstrate the feasibility and effectiveness of the federated learning framework in offering an elevated level of privacy and maintaining utility of the global model.
Cornelia de Lange syndrome: from molecular diagnosis to therapeutic approach (2019)

Cornelia de Lange syndrome (CdLS) is a severe genetic disorder characterised by multisystemic malformations. CdLS is due to pathogenetic variants in <i>NIPBL</i>, <i>SMC1A</i>, <i>SMC3</i>, <i>RAD21</i> and <i>HDAC8</i> genes which belong to the cohesin pathway. Cohesin plays a pivotal role in chromatid cohesion, gene expression, and DNA repair. In this review, we will discuss how perturbations in those biological processes contribute to CdLS phenotype and will emphasise the state-of-art of CdLS therapeutic approaches.
Presence and subcellular localization of tyrosine aminotransferase and p-hydroxyphenyllactate dehydrogenase in epimastigotes of<i>Trypanosoma cruzi</i> (1992)

Cell-free extracts of epimastigotes of Trypanosoma cruzi contain tyrosine aminotransferase (TAT) and p-hydroxyphenyllactate dehydrogenase (pHPLDH). The TAT activity could be separated from aspartate aminotransferase (ASAT) by polyacrylamide gel electrophoresis or DEAE-cellulose chromatography; the latter procedure also allowed complete separation of pHPLDH. The subcellular localization of both T. cruzi enzymes, as determined by digitonin extraction, subcellular fractionation by differential centrifugation, and isopycnic ultracentrifugation in sucrose gradients, was mainly cytosolic, with low mitochondrial activities.
A simple injection port and column holder for use in gas chromatography (1965)

An easily constructed injection port fits directly into a commercial oven, and supports both column and detector within the oven. This leads to improved performance.
A bidirectional fixed‐bed reactor for coupling of exothermic and endothermic reactions (1996)

Abstract Performance of a bidirectional fixed‐bed reactor subject to both flow reversal and switching between exothermic and endothermic reactions is simulated. During odd semicycles (blows) an exothermic reaction heats the bed, during even semicycles an endothermic reaction cools the bed and produces the desired product in the hot zone. Such an operation is possible and efficient when the inlet gas temperature is lower than the initial bed temperature, leading to the wrong‐way behavior when the temperature front moves with a finite velocity (creep velocity) from the feed end to the exit during a semicycle. Since the dynamic nature of the fixed‐bed reactor changes with each semicycle, the front velocity during an exothermic semicycle differs from the front velocity during an endothermic semicycle and an asymptotic expression is developed for the differential creep (front) velocity that quantifies this difference. Due to a nonzero differential creep velocity, the front exhibits an effective displacement after each cycle. This asymptotic expression for the creep velocity works very well except in the inlet and outlet region of the fixed‐bed reactor. An expression developed for 100% energy efficiency shows that it can be reached only if the differential creep velocity is zero. A relation for the balanced operation of a reactor‐regenerator is discussed as well as differences in reactor performance caused by reactions occurring in the gas or solid phase.
Integrated electrostatic micro-switch for opticalfibre networks driven by low voltage (1996)

An improved microswitch for optical networks is presented. Fully integrated on silicon substrate by means of integrated optics technology, it is well suited for mass production. It is characterised by low insertion losses, very low polarisation and wavelength dependence and low driving power.
Effects of epidermal growth factor and insulin on the activity of <i>N</i>-acetylglucosaminyltransferase V (1997)

When quiescent rat hepatocellular carcinoma 7919 cells were treated with epidermal growth factor (EGF) or insulin (stimulators of receptor tyrosine kinase activity), the activity of N-acetylglucosaminyltransferase V was increased. The effect of EGF reached a maximum after 10 min and remained high for 30 min, while the effect of insulin reached a maximum after 5 min and decreased after 15 min. Preincubation of the cells with 1-O-octadecyl-2-O-methylglycerophosphocholine (Et18-OH3), which blocked the activation of mitogen-activated protein kinase by EGF, also blocked the activation of N-acetylglucosamyltransferase V by this hormone, whereas the activation of N-acetylglucosamyltransferase V by insulin could not be blocked by Et18-OH3. Our results suggest that N-acetylglucosamyltransferase V may be regulated by different receptor protein tyrosine kinase pathways.
Oral Sildenafil Improves Primary Pulmonary Hypertension Refractory to Epoprostenol (2005)

In patients with severe PPH refractory to epoprostenol treatment, additional oral sildenafil can improve pulmonary hemodynamics and symptoms. The combination therapy of epoprostenol and sildenafil is a new medical treatment to attempt before progressing to lung transplantation for patients with PPH refractory to epoprostenol.
Speaker Adaptive Cohort Selection for Tnorm in Text-Independent Speaker Verification (2006)

We discuss an extension to the widely used score normalization technique of test normalization (Tnorm) for text-independent speaker verification. A new method of speaker adaptive-Tnorm that offers advantages over the standard Tnorm by adjusting the speaker set to the target model is presented. Examples of this improvement using the 2004 NIST SRE data are also presented.
Gamma interferon (IFN gamma) and IFN<i>alpha</i>/<i>beta</i> suppress murine myeloid colony formation (CFU-C)N: magnitude of suppression is dependent upon level of colony-stimulating factor (CSF). (1982)

The effect of different types of interferon (IFN) on macrophage and granulocyte colony formation (CFU-C) in vitro was studied using bone marrow cells from C57BL/6 mice. CFU-C formation was measured at 7 days using a standard methylcellulose culture system with L-cell conditioned medium (LCCM) as a source of colony-stimulating factor activity (CSF), IFN gamma was obtained from staphylococcal enterotoxin A- (SEA) stimulated mouse spleen cells and was partially purified (50-fold) using affinity chromatography. IFN alpha/beta was obtained from Newcastle disease virus-infected mouse L-cells and was partially purified (286-fold) using an AcA 202 column. IFN gamma inhibited CFU-C formation in a dose-dependent manner and was 100 times more inhibitory than IFN alpha/beta. IFN gamma completely suppressed CFU-C formation with as little as 15 units of antiviral activity. In contrast, 1000 to 2000 units of antiviral activity of IFN alpha/beta was required for complete suppression of CFU-C formation. The ability of IFN gamma to inhibit CFU-C formation was completely abolished after pH 2 treatment (24 hr), heat treatment (60 degrees C, 2 hr), or treatment with a specific antiserum against IFN gamma, which indicated that IFN gamma was the mediator of CFU-C inhibition. When IFN gamma and IFN alpha/beta were mixed together and added to bone marrow cells, they had a synergistic effect on the suppression of CFU-C formation. The level of inhibition mediated by both IFN gamma and IFN alpha/beta was totally dependent upon the amount of CSF present in the culture system; increasing the level of CSF could completely overcome the IFN suppressive effect. These results suggest that IFN gamma and IFN alpha/beta may have regulatory roles in hematopoiesis.
Ultimate Load Capacities of Plane and Axisymmetric Headed Anchors (1999)

A finite-element-based linear elastic fracture mechanics analysis of the pullout of headed anchors is presented. The anchor is modeled as a vertically loaded crack of diameter c, embedded at a depth d, with a rigid upper surface, and traction-free lower surface. The fracture toughness and Poisson's ratio of the surrounding matrix are KIc and ν, respectively. For selected values of d/c, the mode-I stress intensity factor is calculated for each increment of the crack growth, which emanates from the edge of the anchor, and follows the direction of zero mode-II stress intensity factor. The stress intensity factors are used to calculate the ultimate load Pu, which is written as Pu = g(d/c, ν)d3/2KIc. For ν = 0.2 and relatively large values of d/c, g = 2.8 for axisymmetric anchors and g = 1.2 for plane strain anchors.
Beyond superscalar using FPGAs (2002)

A superscalar processor with three execution units is described in details in this paper. The execution units are implemented using reprogrammable field-programmable gate array (FPGA) chips, allowing the user to configure them to best fit the application. Each instruction, composed of 128 bits, directly controls all the processor resources, in a horizontal microprogramming way.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Diphenyl ketimine derivatives as a probe for Group IV pπ–dπ bonding: the structures of M(NCPh<sub>2</sub>)<sub>4</sub>(M = Si, Ge, Sn) (1975)

The crystal structures of the three title compounds have been determined; the dramatic differences in their M–N–C bond angles suggest that Si is subsantially involved in pπ–dπ bonding, that Ge is partially involved, and that Sn shows no pπ–dπ bonding.
Purinergic Control of Neutrophil Activation (2010)

Neutrophils constitute the first line of defense against invading pathogens, but they also are responsible for tissue destruction in pathological conditions. In a recent paper published in Science Signaling, Junger and colleagues show that adenosine 5'-triphosphate release and signaling through purinergic P2 receptors upon neutrophil activation by bacterial and inflammatory stimuli represents an important mechanism for effective neutrophil functional response and host protection.
A new non-invasive approach for monitoring respiratory movements of sleeping subjects (1995)

We have developed a minimally intrusive system to monitor respiratory movements of sleeping subjects. This system is based on a pressure transducer which measures the changes in air pressure inside an inflatable mattress on which the subject sleeps. Using a mechanical filter to protect the transducer against the large pressure changes due to sudden movements and subject weight, we can detect the more subtle movements of the subject's chest. This paper discusses the design of the monitoring system, including the design and modelling of the mechanical filter.
Prognostic Significance of Tissue Factor in Pancreatic Ductal Adenocarcinoma (2005)

Tissue factor (TF) is a transmembrane glycoprotein that plays roles in the blood coagulation and intracellular signaling pathways, and has also been suggested to modulate the biological behavior of cancer cells. In order to examine the clinicopathologic significance of TF expression in pancreatic ductal adenocarcinoma, TF expression was determined by immunohistochemistry using a newly raised anti-TF monoclonal antibody in 113 patients who had undergone surgical resection of pancreatic ductal adenocarcinoma. According to the incidence of tumor cell immunopositivity, patients were divided into "negative TF" (0%), "weak TF" (<25%), or "high TF" (25% or more) groups, which accounted for 11.6% (n = 13), 44.2% (n = 50), and 44.2% (n = 50) of the total, respectively. Increased TF expression was correlated with the extent of the primary tumor (P = 0.0043), lymph node metastasis (P = 0.0043), lymphatic distant metastasis (P = 0.0039), advanced tumor-node-metastasis stage (P = 0.0002), and high tumor grade (P = 0.0164). Multivariate analysis using the Cox proportional hazards model showed that high TF expression was an independent negative predictor for survival (hazard ratio, 2.014; P = 0.0076). Moreover, patients with TF-negative tumors had a significantly better prognosis even if lymph node metastasis was present (P < 0.0001). We also showed that TF knockdown by RNA interference suppressed the invasiveness of a pancreatic adenocarcinoma cell line in vitro. These results indicate that TF expression may contribute to the aggressiveness of pancreatic ductal adenocarcinoma by stimulating tumor invasiveness, and that evaluation of the primary tumor for TF expression may identify patients with a poor prognosis.
An On-chip Calibration Technique for Reducing Supply Voltage Sensitivity in Ring Oscillators (2007)

A technique for reducing the supply voltage sensitivity of a ring oscillator using on-chip calibration is described. A 1-V 0.13-mum CMOS PLL demonstrates robust performance against VCO supply noise over operating frequencies of 0.5 to 2 GHz. In the presence of a 10-mV 1-MHz VCO supply noise, the measured rms jitter of the proposed PLL with on-chip calibration is 3.95 ps at a 1.4-GHz operating frequency, while a conventional design measures 8.22 ps rms jitter. For 10-MHz VCO supply noise, the measured rms jitter is improved from 16.8 ps to 3.97 ps. The total power consumption of the PLL is 9.6 mW at 1.4 GHz, and the combined core die area of the PLL and the calibration circuitry is 0.064 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup>
Paired Comparison Models with Time-Varying Parameters (1993)

Abstract : Paired comparison experiments involve comparisons among a set of objects, treatments, or competitors in blocks of size two to determine relative merits among the objects. Applications to tournament chess competition or team sports differ from the usual paired comparison framework in that competitors' abilities may change over time. A dynamic model is developed for the usual paired comparison experiment in which only a binary indicator of the preferred object is available (or trinary, if ties are allowed), and for alternative paired comparison experiments in which more information (perhaps the score) is available. Posterior distributions of the rating parameters and posterior prediction intervals for the results of future comparisons axe obtained using methods that are closely related to the Kalman filter. The methodology is applied to the analysis of professional football game outcomes and to chess tournament results from the 1988-1989 World Cup.
First silicon experiments within wafers (2003)

Typical industrial practice blocks experiments by lot and treats wafers as homogeneous units. This work demonstrates the practical advantages of varying some factors within wafer. The case study involves an advanced microprocessor, the response of greatest interest is speed, and its critical gate lengths are manipulated by exposure changes within wafer. The experiment is constructed using a spatial design criterion and a constrained optimal design algorithm. Data analysis has 3 steps: (a) for each wafer, model the response as a function of both within-wafer factors and (x,y) coordinates. (b) For each wafer and factor level, average over all site coordinates and other factor levels. (c) across wafers, fit a response surface. An example illustrates, and several practical issues are highlighted.
Integrated low-loss passive SiGe power splitter and combiner operating across 78&#x2013;86 GHz band (2013)

This paper describes the design, implementation, and characterization of a new type of passive power splitting and combining structure for use in a differential four-way power-combining amplifier operating at E-band. In order to achieve lowest insertion loss, input and output coils inductances are resonated with shunt capacitances. Simple C-L-C and L-C networks are proposed in order to compensate inductive loading due to routing line that would otherwise introduce mismatch and increase loss. Across 78-86 GHz band, measured insertion loss is about 7 dB. Measured return losses are >10 dB from 73 GHz to 94 GHz at the input port and >9 dB from 60 GHz to 94 GHz at the output port. When integrated with driver and power amplifier cells, the simulated complete circuit exhibits 18.2 dB gain and 20.3 dBm saturated output power.
Feature matching for object localization in the presence of uncertainty (2002)

The author focuses on the central problem of image and model feature matching. In particular he defines a model of the geometrical uncertainty of image features, and devises a tractable algorithm for determining all feasible sets of feature correspondences given the uncertainty tolerances. A key insight into the matching problem provided by this work is that the search for a matching should be guided by analysis of (feasible) transformation space rather than the space of feature correspondences. This is because the author is only interested in maximal feasible match-sets and not the exponentially many subsets of them as found by correspondence space search.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>