gebhart/patrepeval huggingface dataset:
X-Linked Spinal Muscular Atrophy (Kennedy's Syndrome) (1990)

Kennedy's syndrome, X-linked adult-onset bulbospinal muscular atrophy, has been described in over 30 families. The characteristic distribution of weakness creates a recognizable syndrome, augmented by frequent findings of testicular atrophy and gynecomastia. Type IV or type II hyperlipoproteinemia has been found in some families. We have studied another family with Kennedy's syndrome, this one with hypobetalipoproteinemia. The diversity of serum patterns suggests that lipoprotein abnormalities are not causally related to either the endocrinopathy or the spinal muscular atrophy. However, gene linkage studies indicate proximity of the gene for Kennedy's syndrome and the gene encoding the androgen receptor, which could explain the combination of a motor neuron disorder and the endocrine abnormalities.
External Trapping of Halomethyllithium Enabled by Flow Microreactors (2014)

Abstract This work demonstrates that the accurate control of the reaction parameters realized within microreactor systems allowed for a taming of the reactivity of thermally unstable intermediates such as haloalkyllithiums. The first example of effective external trapping of a reactive carbenoid such as the chloromethyllithium is described. By using microreactor systems, a continuous flow synthesis of chloro alcohols and chloro amines could be achieved with high yields. By controlling the residence time the highly reactive chloromethyllithium could be generated and reacted with electrophiles at temperatures much higher than in batch‐mode and without internal quenching. The developed continuous‐flow process matches the requirements for sustainability. magnified image
Wound healing around endosseous implants in experimental diabetes. (1998)

Wound healing has been shown to be altered in diabetes mellitus. The aim of this study was to identify the effects of streptozotocin-induced diabetes on osseointegration. Diabetes was induced in 40-day-old rats by intraperitoneal injection of 70 mg per kg streptozotocin. At 14 days postinjection, implants were placed in the femora of 10 diabetic and 10 age-matched normal rats. Animals were sacrificed at 28 and 56 days following implantation. Histometric results indicated that the quantity of bone formation was similar for diabetic and control animals (P > .05). However, less bone-implant contact was observed for diabetic compared to control animals at both 28 and 56 days (P < .0001). This study demonstrates that the process of osseointegration is affected by streptozotocin-induced diabetes.
[Cloning, expression and characterization of a gene encoding alpha2 subunit of the proteasome in Schistosoma japonicum]. (2010)

The 26S proteasome is a proteolytic complex responsible for the degradation of the vast majority of eukaryotic proteins. Regulated proteolysis by the proteasome is thought to influence cell cycle progression, transcriptional control, and other critical cellular processes. A novel Schistosoma japonicum gene (GenBank Accession No. AY813725) proteasome alpha2 subunit (SjPSMA2) was cloned. Sequence analysis revealed that the ORF of SjPSMA2 gene contains 708 nucleotides encoding 235 amino acids, and the molecular weight was estimated to be 25.84 kDa. Real-time PCR analysis showed that this gene expressed in 7 d, 13 d, 18 d, 23 d, 32 d and 42 d schistosoma. The mRNA level of SjPSMA2 was lower in 7 d and 23 d schistosomulum than that in other stages. The SjPSMA2 cDNA fragment was subcloned into an expression vector pET28a(+) and transformed into E. coli BL21 (DE3) cells. After induction with IPTCQ the 30 kDa fusion protein was produced as included bodies. Western-blotting revealed that the fusion protein could be recognized by the rabbit serum anti-Schistosoma japonicum adult worm antigen preparation, and the protein in native could be detected. After immunization of BALB/c mice with the fusion protein, the reduction rates of worm counts and liver egg counts were 12.33% and 35.23%. ELISA results revealed that the vaccinated group showed a significant increase in the level of IgG antibody. This study provided an important basis for investigating the regulation mechanism of the proteasome during the development of Schistosoma japonicum.
On Improved Digital Techniques of Pulse Width Measurement (1973)

A digital technique for the instantaneous measurement of pulse width is described in this paper. The techniques make use of a 50 per cent amplitude sampling circuit which converts the varying amplitude pulses into the fixed amplitude pulses require to work with the pulse stretcher and a special stretcher circuit which generates a pulse 100 times as wide as the input pulse. The 50 per cent amplitude sampling circuit senses the peak amplitude and establishes a half amplitude reference level to measure the pulse width of its 50 per cent amplitude. The stretched pulse is used to control the outputs of an oscillator and counter, thereby providing a digital output. The gas discharge numerical indicator tubes allow the pulse width to be read directly in digital form. Accuracy of ± 2 per cent has been achieved for range 0·35–1·2 μsec. pulses with a resolution of 0·01 μsec. A special input circuit is provided which selects only the first two pulses, and uses the second input pulse for measurements.
Evaluation of bacteriophages for prevention and treatment of diarrhea due to experimental enterotoxigenic Escherichia coli K88 infection of weaned piglets (2011)

Colibacillosis in pigs remain a major swine industry bruden worldwide. Although some progress has been made in treating collibacillosis in pigs by using biosecurity and antimicrobials, it still remain a considerable problem. The use of host-specific bateriophages as a biocontrol is one possible alternative. The purpose of this study was to evaluate the effect of bacteriophage against enterotoxigenic Escherichia coli (ETEC) K88 infection in piglets. Twenty-eight piglets were randomly divided into four groups and each group was allocated with 7 pigs. Group B, C and D were inoculated with 5 ml of ETEC K88 (<TEX>$1{\times}10^8$</TEX> CFU/ml) per head of piglet via oral. Group C and D were fed with bacteriophages (Group C, <TEX>$1.0{\times}10^6$</TEX> PFU/g; Group D, <TEX>$1.0{\times}10^8$</TEX> PFU/g; CJ CheilJedang Corp., Korea) orally as treatment. In piglets administrated bacteriophages and challenged with ETEC K88 (Group C and D), Clinical signs and the growth performance were improved and antibody titers were maintained low level compared with piglets challenged with ETEC K88 (Group B, P<0.05). Group B were shown high pH in the alimentary tracts compared with other piglets (P<0.05). In quantitative analysis by real-time PCR, the results of Group C and D were lower than those Group B in faecal and intestinal samples (P<0.05). Severe villus atrophy and crypt hyperplasia were observed in Group B consequently V/C ratio increased, compared with other piglets. These results indicate that feeding with bacteriophage has effect to prevent ETEC K88 infection in piglets and suggest that use of bacteriophage can be considered a valid antibiotic alternative.
Deaf Employment Assistance Network: A Model for Employment Service Delivery (2019)

The successful rehabilitation of deaf clients depends on attention to both individual and environmental factors which hinder vocational attainment and satisfaction. Service providers should be aware of and utilize employment and employability interventions which address these factors. This paper presents a comprehensive model for employment service delivery. An ecological framework is outlined, the model is described, and discussion is offered.
Fate of Endocrine Disrupting Compounds in Membrane Bioreactor Systems (2007)

Yeast estrogen screen (YES) bioassay and liquid chromatography-mass spectrum-mass spectrum (LC-MS-MS) analysis were performed to investigate the fate of active and potential endocrine disrupting compounds in 3 pilot-scale and 2 lab-scale membrane bioreactor (MBR) systems. Compared with the overall estrogenicities of sewage treatment plant (STP) effluents from references, the MBR systems studied have relatively good performance in the removal of estrogenicity. Estrone (E1) was removed with relatively high efficiency (80.2-91.4%), but 17beta-estradiol (E2) was removed with moderate efficiency (49.3-66.5%) by the MBRs. However, the experimental results indicated that after the treatment by MBR, substantial amounts of E1, estrone-3-sulfate (E1-3S), estrone-3-glucuronide (E1-3G), and 17beta-estradiol-glucuronides (E2-G) passed through treatment systems and entered into the aquatic environment. The reduction in the levels of overall equivalent E1 (68.4%) and that of overall equivalent E2 (80.8%) was demonstrated for the pilot-scale MBR-B. For alkylphenol compounds, bisphenol A (BPA) was removed well with a removal efficiency of 68.9 -90.1%, but 4-nonylphenol (4-NP) concentration was amplified (removal efficiency of -439.5 to -161.1%) after MBR treatment which could be caused by the transformation of its parent compounds, nonylphenol polyethoxylates (NPnEOs). The amounts of adsorbed estrogens per kg dry mass was relatively low, due to short hydraulic retention time and high mixed liquor suspended solids in MBRs, compared to that in STPs.
The economics of dairy farming in Canada. (1980)

Government policies affecting the Canadian dairy industry represent a unique solution to a problem of surpluses which exists in most Western countries. This paper sketches an outline of dairy farming today before examining the trends and structural changes undergone by the industry over the Seventies. Milk yields have increased slightly and total numbers of dairy farmers have halved. After a decade of turmoil in international markets for dairy products, some stability is now returning and dairy farmers appear to be on the verge of a technological leap forward in dairying. By the end of the Eighties there could be no more than 13,500 commercial dairy farms supplying milk in Canada.Canada, along with other Western countries, produces more milk protein than it needs and different proposals for redressing this imbalance in the Eighties are appraised. One proposal advocates cutting back on domestic production and purchasing butter to make up the difference on the international market. A scheme based on recent British analysis proposes a swing towards Jersey milk production. Lastly the possibility of expanding market demand for products rich in milk protein is examined.
Comparative analysis of a TCPWM with SVPWM connected to three phase load (2017)

As now days, it's very important to have continues supply, we have to see some good alternative so that we can store power in form of DC whenever there is excess production. And we can use it as we require to have continues supply. So overcome these problem there any many techniques are used such as inverter, UPS etc. Technique which is used now a day is TCPWM which is also called as SPWM. There is one more technique which is becoming more interested with respect to research is SVPWM. As it is having many advantages as compared with TCPWM.
Label Propagation for Deep Semi-Supervised Learning (2019)

Semi-supervised learning is becoming increasingly important because it can combine data carefully labeled by humans with abundant unlabeled data to train deep neural networks. Classic methods on semi-supervised learning that have focused on transductive learning have not been fully exploited in the inductive framework followed by modern deep learning. The same holds for the manifold assumption-that similar examples should get the same prediction. In this work, we employ a transductive label propagation method that is based on the manifold assumption to make predictions on the entire dataset and use these predictions to generate pseudo-labels for the unlabeled data and train a deep neural network. At the core of the transductive method lies a nearest neighbor graph of the dataset that we create based on the embeddings of the same network. Therefore our learning process iterates between these two steps. We improve performance on several datasets especially in the few labels regime and show that our work is complementary to current state of the art.
The BBCH system to coding the phenological growth stages of plants – history and publications – (2008)

The growth stages of development of many cultivated plants have been described by numerous scientists according to the principles of the extended BBCH scale within the last 19 years. The BBCH scales are now well- known worldwide and are used by research, administration and practise in agriculture and horticulture, as in the phenology as an integrative science in environment, meteorology and climatology. This fact indicates that the basic objectives and hope have been reached, justifying the practical approach taken by the authors of this scale. The BBCH scale is a contribution to improve the communication between different groups of scientists and to allow the interchange of data and scientific results in a transparent way. The BBCH scales have turned out helpful and practical. The aim to cause the harmonisation in the application of decimal codes for the description of the phenological growth stages of plants and weeds was reached. They also fulfilled the hope of the initiators to contribute with it to the improvement of the international agrarian-scientific and interdisciplinary communication. This paper will describe the history and background of the BBCH scales. The original publications are described and explained with reference of the original literature sources. The paper will describe the different area of use of the scales and list the different scientific disciplines using them. The worldwide success of the BBCH scales is the work of many scientists around the globe.
Segmentation of Motion Objects from Surveillance Video Sequences Using Temporal Differencing Combined with Multiple Correlation (2009)

Identifying moving objects from a video sequence is a fundamental and critical task in many computer vision applications. We develop an efficient adaptive segmentation algorithm for color video surveillance sequence in real time with non-stationary background; background is modeled using multiple correlation coefficient using pixel-level based approach. At runtime, segmentation is performed by checking color intensity values at corresponding pixels P(x,y) in three frames using temporal differencing (frame gap three). The segmentation starts from a seed in the form of 3times3 image blocks to avoid the noise. Usually, temporal differencing generates holes in motion objects. After subtraction, holes are filled using image fusion, which uses spatial clustering as criteria to link motion objects. The emphasis of this approach is on the robust detection of moving objects even under noise or environmental changes (indoor as well as outdoor).
ChemInform Abstract: Preparation and Crystal Structure of Barium Caesium Undecaphosphide‐ Ammonia (1/11) BaCsP11×11 NH3. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Separation virtual machine monitors (2012)

Separation kernels are the strongest known form of separation for virtual machines. We agree with NSA's Information Assurance Directorate that while separation kernels are stronger than any other alternative, their construction on modern commodity hardware is no longer justifiable. This is because of orthogonal feature creep in modern platform hardware. We introduce the separation VMM as a response to this situation and explain how we prototyped one.
Total Synthesis of Palmarumycin CP<sub>1</sub> and (±)-Deoxypreussomerin A (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTotal Synthesis of Palmarumycin CP1 and (±)-Deoxypreussomerin APeter Wipf and Jae-Kyu JungView Author Information Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 Cite this: J. Org. Chem. 1998, 63, 11, 3530–3531Publication Date (Web):May 12, 1998Publication History Received30 March 1998Published online12 May 1998Published inissue 1 May 1998https://pubs.acs.org/doi/10.1021/jo980576vhttps://doi.org/10.1021/jo980576vrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views439Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical synthesis,Ethers,Metabolism,Organic synthesis,Pharmaceuticals Get e-Alerts
Effect of <i>Centella asiatica</i> on arsenic induced oxidative stress and metal distribution in rats (2006)

Concomitant oral supplementation of Centella asiatica (100, 200 or 300 mg kg(-1), orally once daily) during arsenic exposure (20 ppm in drinking water for 4 weeks) was investigated in rats for its protective value. The animals exposed to arsenic (III) showed a significant inhibition of delta-aminolevulinic acid dehydratase (ALAD) activity, a marginal decrease in glutathione (GSH) and an increase in zinc protoporphyrin (ZPP) level in blood. Hepatic and renal glutathione (GSH) decreased, while oxidized glutathione (GSSG) and thiobarbituric acid reactive substance (TBARS) levels increased significantly in the liver, kidney and brain. The activities of brain superoxide dismutase (SOD) and catalase decreased marginally on arsenic exposure. Concomitant administration of Centella asiatica showed a significant protective action on inhibited blood ALAD activity and restored the blood GSH level, whereas most of the other blood biochemical parameters remained unchanged on Centella asiatica supplementation. Interestingly, most of the hepatic biochemical variables indicative of oxidative stress showed protection. There was, however, a significant protection observed in the altered kidney GSSG level and hepatic and brain TBARS. Only a marginal beneficial effect of Centella asiatica on blood and liver arsenic concentration was noted, particularly at the highest dose studies (300 mg kg(-1)). No effect of Centella asiatica on most of the altered renal biochemical parameters was noted. The results thus lead to the conclusion that simultaneous supplementation of Centella asiatica significantly protects against arsenic-induced oxidative stress but does not influence the arsenic concentration in these organs. It can thus be suggested that co-administration of Centella asiatica protects animals from arsenic-induced oxidative stress but exhibits no chelating property. Further studies are recommended for determining the effect of co-administration of Centella asiatica during chelation therapy with a thiol chelator.
Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice (2015)

Persistent intracerebral hemorrhage (ICH) is a major cause of death and disability after traumatic brain injury (TBI) for which no medical treatment is available. Delayed bleeding is often ascribed to consumptive coagulopathy initiated by exposed brain tissue factor. We examined an alternative hypothesis, namely, that marked release of tissue-type plasminogen activator (tPA) followed by delayed synthesis and release of urokinase plasminogen activator (uPA) from injured brain leads to posttraumatic bleeding by causing premature clot lysis. Using a murine model of severe TBI, we found that ICH is reduced in tPA(-/-) and uPA(-/-) mice but increased in PAI-1(-/-) mice compared with wild-type (WT) mice. tPA(-/-), but not uPA(-/-), mice developed a systemic coagulopathy post-TBI. Tranexamic acid inhibited ICH expansion in uPA(-/-)mice but not in tPA(-/-) mice. Catalytically inactive tPA-S(481)A inhibited plasminogen activation by tPA and uPA, attenuated ICH, lowered plasma d-dimers, lessened thrombocytopenia, and improved neurologic outcome in WT, tPA(-/-), and uPA(-/-) mice. ICH expansion was also inhibited by tPA-S(481)A in WT mice anticoagulated with warfarin. These data demonstrate that protracted endogenous fibrinolysis induced by TBI is primarily responsible for persistent ICH and post-TBI coagulopathy in this model and offer a novel approach to interrupt bleeding.
Stratospheric Ozone Destruction by Man-Made Chlorofluoromethanes (1974)

Calculations indicate that chlorofluoromethanes produced by man can greatly affect the concentrations of stratospheric ozone in future decades. This effect follows the release of chlorine from these compounds in the stratosphere. Present usage levels of chlorofluoromethanes can lead to chlorine-catalyzed ozone destruction rates that will exceed natural sinks of ozone by 1985 or 1990.
Susceptibility diagram of multipactor discharge on a dielectric-effects of an external magnetic field and oblique RF electric field (2003)

Summary form only given. Monte-Carlo simulations have recently been used to construct the susceptibility diagram of multipactor discharge on a dielectric, under the assumption that the RF electric field is parallel to the dielectric surface. This diagram, constructed from kinematic considerations, turns out to be extremely useful in the prediction of the saturation level. We generalize the susceptibility diagram in two aspects: inclusion of an external magnetic field and the effects of an oblique RF electric field. It is found that the presence of an external magnetic field does not qualitatively change the susceptibility diagram, regardless of the orientation of the magnetic field. This statement holds for all magnetic fields simulated, up to those values whose cyclotron frequency is on the order of the RF frequency.
Ammonium and Chloride Extrusion: Hyperpolarizing Synaptic Inhibition in Spinal Motoneurons (1971)

The reversal potential of postsynaptic inhibition shifts toward resting membrane potentials in cat spinal motoneurons after intravenous infusion of ammonium salts(1 to 3 millimoles per kilogram of body weight). Simultaneously, the depolarizing action of intracellularly injected chloride ions on the inhibitory membrane is enhanced and recovery therefrom is prolonged. Passive membrane properties remain unaltered. The results indicate a blocking of active extrusion of chloride which normally maintains a high ionic gradient for hyperpolarizing inhibition.