gebhart/patrepeval huggingface dataset:
<i>Lippia alba</i>Mill N.E. Br. (Verbenaceae) as a Source of Linalool (1998)

Abstract The essential oil from the leaves of Lippia alba was analyzed by GC (retention indices) and GC/MS. Linalool proved to be the major constituent (78.9%), besides 1,8-cineole (6.5%), germacrene D (35%), β-caryophyllene (2.7%) and α-terpineol (2.0%). This species is worthy of examination as a rosewood oil substitute.
Regional lung strain in dogs during deflation from total lung capacity (1985)

Regional lung distortion during deflation from total lung capacity to functional residual capacity (FRC) in intact supine and prone anesthetized dogs was determined from the displacement of multiple metallic markers embedded in the lung parenchyma. Distortion was expressed as strain (epsilon), which is related to fractional length changes. In the supine position, transverse strain (epsilon yy) was larger than vertical strain (epsilon xx) and cephalocaudal strain (epsilon zz) in the upper lobe. The FRC of the lower lobe was smaller than FRC of the upper lobe and all strains were larger, but epsilon zz increased most and became equal to epsilon yy. In the prone position, epsilon yy was largest in all upper lobes and in three of four lower lobes. Strains and volumes of the upper and lower lobes were similar. The upper and lower lobes rotated slightly around different axes, indicating that interpleural fissures allow additional degrees of freedom for the lungs to conform to the thoracic cavity. In the prone position, there were no consistent gradients of strain or volume. These results indicate that, in determining the regional distribution of FRC in the recumbent dog, in addition to the effect of gravity on the lung, there are important interactions between lung and thoracic cavity shapes.
Cubic Phase Nanoparticles (Cubosome):  Principles for Controlling Size, Structure, and Stability (2005)

Methods and compositions for producing lipid-based cubic phase nanoparticles were first discovered in the 1990s. Since then a number of studies have been presented, but little is known about how to control key properties such as particle size, morphology, and stability of cubic phase dispersions. In the present work we give examples of how these properties can be tuned by composition and processing conditions. Importantly we show that stable particle dispersions with consistent size and structure can be produced by a simple processing scheme comprising a homogenization and heat treatment step.
Umbilical‐Cord‐Blood‐Derived Suppressor Cells of the Human Natural Killer Cell Activity Are Inhibited by Interferon (1982)

The natural killer (NK) activity of umbilical-cord-derived lymphocytes was studied. The general level of activity was lower than with adult lymphocytes against K-562 cells and fetal fibroblasts. The activity could be boosted by interferon pretreatment of effect or cells, fractionated with Percoll density gradient centrifugation, and the suppressive activity of different fractions was tested on highly enriched adult buffy-coat-derived NK cells. Allogeneic adult NK cell activity could be inhibited in 9 of 20 cases tested with small and medium-sized T lymphocytes (Percoll fractions 4-5) from the umbilical cord. The suppressive capacity was further enriched in fractions forming rosettes (RFC) with antibody-coated human erythrocytes (EA). Such EA-RFC of percoll fraction 4-5 from umbilical cord exerted a strong suppressive activity in each case tested. Pretreatment of EA-RFC with interferon regularly abolished the suppressive effect. We conclude that there are Fc-receptor-positive small/medium-sized T lymphocytes in the umbilical cord blood which can efficiency suppress the cytotoxic activity of NK cells and that the suppressive activity can be abolished by interferon pretreatment of the suppressor cells.
Substituted 1-Phenyl-3-(pyridin-2-yl)urea Negative Allosteric Modulators of mGlu<sub>5</sub>: Discovery of a New Tool Compound VU0463841 with Activity in Rat Models of Cocaine Addiction (2013)

Cocaine is a powerful and highly addictive stimulant that disrupts the normal reward circuitry in the central nervous system (CNS), producing euphoric effects. Cocaine use can lead to acute and life threatening emergencies, and abuse is associated with increased risk for contracting infectious diseases. Though certain types of behavioral therapy have proven effective for treatment of cocaine addiction, relapse remains high, and there are currently no approved medications for the treatment of cocaine abuse. Evidence has continued to accumulate that indicates a critical role for the metabotropic glutamate receptor subtype 5 (mGlu5) in the modulation of neural circuitry associated with the addictive properties of cocaine. While the small molecule mGlu5 negative allosteric modulator (NAM) field is relatively advanced, investigation into the potential of small molecule mGlu5 NAMs for the treatment of cocaine addiction remains an area of high interest. Herein we describe the discovery and characterization of a potent and selective compound 29 (VU0463841) with good CNS exposure in rats. The utility of 29 (VU0463841) was demonstrated by its ability to attenuate drug seeking behaviors in relevant rat models of cocaine addiction.
From cytogenomic to epigenomic profiles: monitoring the biologic behavior of in vitro cultured human bone marrow mesenchymal stem cells (2012)

Because we revealed a significant decrease in DNA methylation levels in hBM-MSCs during long-term culture, it is very important to unravel how these modifications can influence the biologic features of hBM-MSCs to keep track of this organized program and also to clarify the conflicting observations on hBM-MSC malignant transformation in the literature.
Detergent-Free Incorporation of a Seven-Transmembrane Receptor Protein into Nanosized Bilayer Lipodisq Particles for Functional and Biophysical Studies (2012)

SMA-Lipodisq nanoparticles, with one bacteriorhodopsin (bR) per 12 nm particle on average (protein/lipid molar ratio, 1:172), were prepared without the use of detergents. Using pulsed and continuous wave nitroxide spin label electron paramagnetic resonance, the structural and dynamic integrity of bR was retained when compared with data for bR obtained in the native membrane and in detergents and then with crystal data. This indicates the potential of Lipodisq nanoparticles as a useful membrane mimetic.
Aligned Cell Sheets Grown on Thermo‐Responsive Substrates with Microcontact Printed Protein Patterns (2008)

The thermo-responsive polymer poly(N-isopropylacrylamide) is microcontact printed with fibronectin lanes. Cells seeded onto these substrates form globally aligned tissue sheets that can be harvested by lowering the temperature.
Gas‐liquid mass transfer in taylor flow through a capillary (1992)

Abstract The gas‐liquid mass transfer in two‐phase flow through a capillary has been measured for water‐air, ethanol‐air and ethylene glycol‐air systems. A semi‐theoretical model has been developed and compared with experimental results. and a full computer simulations of the flow pattern and mass transfer using a flow simulation program have been made. The measured values are about 30% less than the calculated values.
Relationship between the expression of CD133, HIF-1α, VEGF and the proliferation and apoptosis in hypoxic human prostate cancer cells (2017)

This study measured the levels of expression of CD133, hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) in human prostate cancer cells grown under hypoxic and non-hypoxic conditions to compare the values to resulting amounts of proliferation and apoptosis in the cells. Human prostate cancer cell line LNCaP cells were routinely thawed, cultured and passaged. Actively growing cells were divided into batches. Cells in the control group were grown under 5% CO<sub>2</sub> + 20% O<sub>2</sub>, and those in the hypoxia group were grown under 5% CO<sub>2</sub> + 1% O<sub>2</sub>. The experiments were performed after 12, 24 and 72 h under each growth condition. The percentages of CD13<sup>+</sup> cells were detected by flow cytometry, the expression of HIF-1α and VEGF was detected by western blot analysis, the cell proliferation rate was detected by the MTT assay, and the apoptotic rate was detected by flow cytometry. The results showed that the percentage of CD133<sup>+</sup> cells, and the expressions of HIF-1α and VEGF for the cells in the hypoxia group increased gradually from 12 to 24, to 72 h, while there were no equivalent changes in the control group. Cell proliferation in the two groups increased gradually from 12 to 24, to 72 h, but was significantly higher at all time-points in the hypoxia group (p<0.05). There was no significant difference in terms of the amount of apoptotic cells at any of the three different time-points in either group, but the apoptotic cells in the hypoxia group were significantly less than those in the control group at each time-point, and the difference was statistically significant (p<0.05). We conclude that the expression of CD133<sup>+</sup>, HIF-1α and VEGF in human prostate cancer cells is related to conditions of hypoxia, which ultimately promotes the proliferation and reduces apoptosis in these cells.
Maximizing the net present value of a project subject to materials and capital constraints (1987)

Abstract Large projects in a variety of industries must be scheduled subject to constraints on capital availability with the objective of maximizing their net present value. The effects of capital and materials costs and constraints have been discussed separately in the project management literature, but they have yet to be treated in an integrated fashion. A framework summarizing the previous research on resource constrained project scheduling is presented in this article and the limited role of monetary objectives in the previous research is illustrated. A new approach to the project scheduling problem is presented where the net present value of a project is maximized subject to capital and material constraints. The major benefit of this approach is that it allows managers to optimize the monetary objectives for a project. A series of examples illustrates the necessity of considering materials costs and constraints in project management. The inclusion of materials management factors in developing a project schedule is shown to lead to lower total project costs. It is demonstrated that the failure to consider materials in the initial planning of a project may lead to either unprojected delays in a project, higher costs, or both. Continued research on this problem is needed in a number of areas. Due to the computational complexity and importance of this problem in practice, it is necessary to develop heuristic approaches to derive project schedules. Future research should compare the results for the existing approaches that minimize project duration to those with monetary objective functions to determine the magnitude of the monetary difference between the former and the latter. Finally, the approach considered in this article should be extended to the multiproject environments where it is necessary to make capital allocation decisions among competing projects.
Inverter-based 1V transimpedance amplifier in 90nm CMOS for medical ultrasound imaging (2009)

In this paper, we propose a 1 V transimpedance amplifier design based on an inverter based cascode amplifier as opposed to the conventional transimpedance amplifier based on an Operational Transconductance Amplifier (OTA). The proposed amplifier is designed to amplify the signals from Capacitive Micro machined Ultrasound Transducers (CMUTs) in the frequency bandwidth from 15 MHz to 45 MHz with a center frequency of 30 MHz for medical ultrasound imaging systems. From the measurements, the proposed single-ended transimpedance amplifier achieves a voltage gain of 18.9 dB, an output noise power spectral density of 0.0421 (¿V)/SQRT(Hz) at a center-frequency of 30 MHz, and a total harmonic distortion of -23.16 dB, at 450 mV p-p output voltage at 30 MHz input signal frequency. It draws only 598 ¿A current per amplifier from a 1-V power supply. The proposed single-ended trans-impedance amplifier was fabricated in a 90-nm CMOS technology and it's area measured to be about 32.4 ¿m × 32.4 ¿m only per amplifier.
<i>Geotrichum candidum</i> NRRL Y‐553 lipase: Purification, characterization and fatty acid specificity (1991)

Lipases from Geotrichum candidum NRRL Y-553 are of interest because of their unique specificity for cis-9-unsaturated fatty acids relative to both stearic and palmitic acids. The lipases were partially purified by chromatography on Octyl Sepharose, AG MP-1 macroporous anion exchanger, and chromatofocusing resin. The preparation was found to contain multiple, glycosylated lipases varying slightly in pI (pI 4.88, 4.78, 4.65, 4.57 and 4.52) as judged by both activity and silver staining. The molecular mass determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis was 64 kilodaltons for the main species, with minor species of 60 and 57 kilodaltons present as well. The specificity of the crude lipases for hydrolysis of 4-methylumbelliferyl esters of oleic vs. palmitic acid was 20-to-1. The specificity of the purified, partially separated lipases was similar to that of the crude preparation. Thus the lipases could be used even in crude form for the hydrolysis and restructuring of triacylglycerols on a large scale.
Recommendation for Key Management Part 1: General (2016)

3541 et seq., Public Law (P.L.) 113-283. NIST is responsible for developing information security standards and guidelines, including minimum requirements for federal information systems, but such standards and guidelines shall not apply to national security systems without the express approval of appropriate
Effect of immune serum on the growth of Babesia microti in hamster erythrocytes in short-term culture (1979)

Short-term in vitro culture of Babesia microti was obtained. Immune hamster serum had an inhibitory effect on the growth of B. microti in vitro. It is suggested that these antibodies act by preventing penetration of erythrocytes by the parasite.
The effect of aspirin on pain and hand blood flow responses to intra‐arterial injection of bradykinin in man (1966)

A new method of evoking pain by the intra‐arterial injection of bradykinin (into the brachial artery) was used in the evaluation of the analgesic activity of sodium and calcium acetylsalicylate. At the same time, hand blood flows were measured by venous occlusion plethysmography, and the plasma was analyzed for acetyl, free, and protein‐bound salicylate. The analgesic effect of aspirin appears during the second half of the first hour and continues beyond the second hour after drug administration. Bradykinin increases the hand blood flow and there is an apparent increase in flow after aspirin. No correlation could be found between the plasma salicylate level and the state of analgesia.
Methionine Ligand Lability of Homologous Monoheme Cytochromes <i>c</i> (2014)

Direct electrochemical analysis of adsorbed bacterial monoheme cytochromes c has revealed a phenomenological loss of the axial methionine when examined using pyrolytic "edge-plane" graphite (EPG) electrodes. While prior findings have reported that the Met-loss state may be quantitatively understood using the cytochrome c from Hydrogenobacter thermophilus as a model system, here we demonstrate that the formation of the Met-loss state upon EPG electrodes can be observed for a range of cytochrome orthologs. Through an electrochemical comparison of the wild-type proteins from organisms of varying growth temperature optima, we establish that Met-ligand losses at graphite surfaces have similar energetics to the "foldons" for known protein folding pathways. Furthermore, a downward shift in reduction potential to approximately -100 mV vs standard hydrogen electrode was observed, similar to that of the alkaline transition found in mitochondrial cytochromes c. Pourbaix diagrams for the Met-loss forms of each cytochrome, considered here in comparison to mutants where the Met-ligand has been substituted to His or Ala, suggest that the nature of the Met-loss state is distinct from either a His-/aquo- or a bis-His-ligated heme center, yet more closely matches the pKa values found for bis-His-ligated hemes., We find the propensity for adoption of the Met-loss state in bacterial monoheme cytochromes c scales with their overall thermal stability, though not with the specific stability of the Fe-Met bond.
C for system level design (1999)

Article Free Access Share on C for system level design Author: Guido Arnout CoWare, Inc. CoWare, Inc.View Profile Authors Info & Claims DATE '99: Proceedings of the conference on Design, automation and test in EuropeJanuary 1999 Pages 81–eshttps://doi.org/10.1145/307418.307528Online:01 January 1999Publication History 14citation144DownloadsMetricsTotal Citations14Total Downloads144Last 12 Months9Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Applied tomography: Monitoring the Gulf Stream extension (1990)

From July to October of 1990, an applied tomography demonstration experiment was conducted in the North Atlantic in the area between Bermuda and North America. The highly variable eastward extension of the Gulf Stream Current was of particular interest. Acoustic sources placed on the bottom near Bermuda transmitted every 4 h, and at times every 40 min, to bottom hydrophones north of the Gulf Stream. The signals were replica processed and the results relayed to the Applied Physics Laboratory in an unattended near real-time mode of operation. In addition, a ship towing a hydrophone array on the northern side of the Gulf Stream received the tomography transmissions during a 1 week period. Sample data results for a single slice through the Gulf Stream are presented. The results show consistent and trackable multipaths that are used to monitor the position of the Gulf Sream. Furthermore, a high-resolution image of the Gulf Stream between 60 and 70 deg west longitude was obtained from the towed array data. Independent comparison data are also presented. [Work supported by the Oceanographer of the Navy and ONR.]
Reference strains for the serologic groups of meningococcus (Neisseria meningitidis) (1958)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
청소년지도자의 개인자원과 직무자원, 보수만족이 일몰입과 근무지속의지에 미치는 영향: 직무요구-자원(JD-R) 모형의 관점에서 (2016)

본 연구는 일몰입을 청소년지도자의 근무지속의지에 영향을 미치는 중요한 매개변수로 가정하고, 청소년지도자의 개인자원과 직무자원, 보수만족이 일몰입과 근무지속의지에 미치는 영향력을 구조방정식 모형에 적용하여 검증하였다. 전국의 청소년시설에 종사하는 청소년지도자를 대상으로 설문조사를 실시하였으며, 회수된 368매의 설문지 중 분석에 적합하지 않은 42매를 제외한 326매가 분석에 활용되었다. 자료는 Amos 22를 통해 분석되었다. 조사를 통해 나타난 결과는 다음과 같다. 첫째, 청소년지도자의 일몰입은 근무지속 의지에 정적인 직접효과를 갖는 것으로 나타났다. 둘째, 청소년지도자의 개인자원과 직무자원은 일몰입에 정적인 직접효과를 갖는 반면, 보수만족은 일몰입에 직접적인 영향을 미치지 않는 것으로 나타났다. 셋째, 청소년지도자의 직무자원과 보수만족은 근무지속 의지에 정적인 직접효과를 갖는 반면, 개인자원은 부적인 직접효과를 갖는 것으로 나타났다. 넷째, 일몰입을 매개로 하여 개인자원과 직무자원, 보수만족이 근무지속 의지에 영향을 미치는지를 검증한 결과 개인자원과 직무자원은 일몰입을 매개로 하여 유의한 간접효과를 가졌다. 마지막으로 본 연구 결과들이 갖는 시사점 및 제한 점이 논의되었다.
Fractionation of nucleic acids by isoelectric focusing (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFractionation of nucleic acids by isoelectric focusingJames W. Drysdale and Piergiorgio RighettiCite this: Biochemistry 1972, 11, 22, 4044–4052Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://pubs.acs.org/doi/10.1021/bi00772a006https://doi.org/10.1021/bi00772a006research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Perspective: Prospects of non-invasive sensing of the human brain with diffuse optical imaging (2018)

Since the initial demonstration of near-infrared spectroscopy (NIRS) for noninvasive measurements of brain perfusion and metabolism in the 1970s, and its application to functional brain studies (fNIRS) in the 1990s, the field of noninvasive optical studies of the brain has been continuously growing. Technological developments, data analysis advances, and novel areas of application keep advancing the field. In this article, we provide a view of the state of the field of cerebral NIRS, starting with a brief historical introduction and a description of the information content of the NIRS signal. We argue that NIRS and fNIRS studies should always report data of both oxy- and deoxyhemoglobin concentrations in brain tissue, as they complement each other to provide more complete functional and physiological information, and may help identify different types of confounds. One significant challenge is the assessment of absolute tissue properties, be them optical or physiological, so that relative measurements account for the vast majority of NIRS and fNIRS applications. However, even relative measurements of hemodynamics or metabolic changes face the major problem of a potential contamination from extracerebral tissue layers. Accounting for extracerebral contributions to fNIRS signals is one of the most critical barriers in the field. We present some of the approaches that were proposed to tackle this challenge in the study of cerebral hemodynamics and functional connectivity. Finally, we critically compare fNIRS and functional magnetic resonance imaging (fMRI) by relating their measurements in terms of signal and noise, and by commenting on their complementarity.
En las redes del tiempo (2009)

RESUMENl artculo rastrea las huellas de la memoria, el viaje temporal y la representacin liminar del tiempo a travs de pelculas fundamentales del cine moderno y sus prolongaciones en el audiovisual contemporneo.Empleando como vehculo analtico las figuraciones de la amnesia, el trauma memorstico y los estados post-mortem, el texto explora el rgimen de filiacin entre tales ficciones de la ruptura identitaria y sus paralelos