gebhart/patrepeval huggingface dataset:
Temporal kernel CCA and its application in multimodal neuronal data analysis (2009)

Data recorded from multiple sources sometimes exhibit non-instantaneous couplings. For simple data sets, cross-correlograms may reveal the coupling dynamics. But when dealing with high-dimensional multivariate data there is no such measure as the cross-correlogram. We propose a simple algorithm based on Kernel Canonical Correlation Analysis (kCCA) that computes a multivariate temporal filter which links one data modality to another one. The filters can be used to compute a multivariate extension of the cross-correlogram, the canonical correlogram, between data sources that have different dimensionalities and temporal resolutions. The canonical correlogram reflects the coupling dynamics between the two sources. The temporal filter reveals which features in the data give rise to these couplings and when they do so. We present results from simulations and neuroscientific experiments showing that tkCCA yields easily interpretable temporal filters and correlograms. In the experiments, we simultaneously performed electrode recordings and functional magnetic resonance imaging (fMRI) in primary visual cortex of the non-human primate. While electrode recordings reflect brain activity directly, fMRI provides only an indirect view of neural activity via the Blood Oxygen Level Dependent (BOLD) response. Thus it is crucial for our understanding and the interpretation of fMRI signals in general to relate them to direct measures of neural activity acquired with electrodes. The results computed by tkCCA confirm recent models of the hemodynamic response to neural activity and allow for a more detailed analysis of neurovascular coupling dynamics.
Endogenous Monocyte Chemoattractant Protein-1 (MCP-1) Protects Mice in a Model of Acute Septic Peritonitis: Cross-Talk Between MCP-1 and Leukotriene B4 (1999)

We investigated the involvement of monocyte chemoattractant protein (MCP)-1 in a murine model of septic peritonitis induced by cecal ligation and puncture (CLP). Initial studies demonstrated that CLP induced a dramatic increase in MCP-1 production in the peritoneum, followed by an increase in the recruitment of leukocytes. MCP-1 blockade with anti-MCP-1 antiserum significantly decreased the survival rate following CLP, which was accompanied by an enhanced recovery of viable bacteria from the peritoneum. This was likely due to the reduction in the recruitment and activation of both macrophages and neutrophils. To understand the mechanisms whereby MCP-1 may influence neutrophil infiltration, levels of chemokines known to attract neutrophils were monitored, which showed that peritoneal levels of macrophage-inflammatory protein (MIP)-2, KC, and MIP-1alpha were not altered with anti-MCP-1 Abs. However, anti-MCP-1 Abs reduced the peritoneal levels of leukotriene B4 (LTB4) by 59%. The i.p. injection of MCP-1 into normal mice resulted in elevated levels of LTB4 in the peritoneum. In vitro, MCP-1 stimulated the production of LTB4 from peritoneal macrophages, in a dose-dependent manner. A specific LTB4 receptor antagonist (CP-105, 696) inhibited CLP-induced recruitment of both neutrophils and macrophages, which was accompanied by a reduced level of MCP-1 in the peritoneum. Finally, administration of CP-105,696 was extremely detrimental to the survival of mice following CLP. These experiments demonstrate that endogenous MCP-1 serves as an indirect mediator to attract neutrophils via the production of LTB4, and suggest the cross-talk can occur between MCP-1 and the lipid mediator LTB4 during septic peritonitis.
Determination of nitrite by controlled-potential coulometry (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of nitrite by controlled-potential coulometryJackson E. HarrarCite this: Anal. Chem. 1971, 43, 1, 143–145Publication Date (Print):January 1, 1971Publication History Published online1 May 2002Published inissue 1 January 1971https://pubs.acs.org/doi/10.1021/ac60296a027https://doi.org/10.1021/ac60296a027research-articleACS PublicationsRequest reuse permissionsArticle Views117Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Linear and inversive pseudorandom numbers for parallel and distributed simulation (1998)

We discuss the use and possible abuse of linear and inversive pseudorandom numbers (PRNs) in parallel and distributed environments. After an investigation of properties of PRNs which determine how these may be applied in such environments, we introduce a software package which provides a unified and easy to use approach to the generating and handling of parallel streams of such PRNs. Experimental results are conducted which describe the features of the software package and compare the performance of two selected types of pseudorandom number generators.
A Database Index to Large Biological Sequences (2001)

We present an approach to searching genetic DNA sequences using an adaptation of the suffix tree data structure deployed on the general purpose persistent Java platform, PJama. Our implementation technique is novel, in that it allows us to build suffix trees on disk for arbitrarily large sequences, for instance for the longest human chromosome consisting of 263 million letters. We propose to use such indexes as an alternative to the current practice of serial scanning. We describe our tree creation algorithm, analyse the performance of our index, and discuss the interplay of the data structure with object store architectures. Early measurements are presented.
Direct numerical analysis of dual-mode elliptical-core optical fibers (1991)

A direct solution of the scalar wave equation (SWE) for an elliptical-core weakly guiding fiber is considered. We decompose the SWE into two ordinary differential equations by using the method of separation of variables, demand the periodicity of the solution in terms of the angular coordinate, and, by matching the boundary conditions numerically, obtain the characteristic propagation curves for the two modes. A simple computer program permits the acquisition of two-mode fiber device parameters as functions of the core ellipticity, the core dimensions, and the refractive-index difference.
Synthesis of Photocleavable Poly(styrene-<i>block</i>-ethylene oxide) and Its Self-Assembly into Nanoporous Thin Films (2008)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of Photocleavable Poly(styrene-block-ethylene oxide) and Its Self-Assembly into Nanoporous Thin FilmsMinhyuck Kang and Bongjin Moon*View Author Information Department of Chemistry, Sogang University, Seoul 121-742, Korea* Corresponding author. E-mail: [email protected]Cite this: Macromolecules 2009, 42, 1, 455–458Publication Date (Web):December 16, 2008Publication History Received31 October 2008Revised14 November 2008Published online16 December 2008Published inissue 13 January 2009https://pubs.acs.org/doi/10.1021/ma802434ghttps://doi.org/10.1021/ma802434gbrief-reportACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views4834Altmetric-Citations156LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copolymers,Gel permeation chromatography,Irradiation,Radical polymerization,Thin films Get e-Alerts
Dropwise Condensation on Micro- and Nanostructured Surfaces (2014)

In this review we cover recent developments in the area of surface-enhanced dropwise condensation against the background of earlier work. The development of fabrication techniques to create surface structures at the micro- and nanoscale using both bottom-up and top-down approaches has led to increased study of complex interfacial phenomena. In the heat transfer community, researchers have been extensively exploring the use of advanced surface structuring techniques to enhance phase-change heat transfer processes. In particular, the field of vapor-to-liquid condensation and especially that of water condensation has experienced a renaissance due to the promise of further optimizing this process at the micro- and nanoscale by exploiting advances in surface engineering developed over the last several decades.
Dreaming in plastic (2008)

Plastic is one of the most versatile materials available. It is cheap, flexible and easy to process, and as a result it is all around us – from our computer keyboards to the soles of our shoes. One of its most common applications is as an insulating coating for electric wires; indeed, plastic is well known for its insulating characteristics. It came as something of a surprise, therefore, when in the late 1970s a new generation of plastics was discovered that displayed exactly the opposite behaviour – the ability to conduct electricity. In fact, plastics can be made with a whole range of conductivities – there are polymer materials that behave like semiconductors and there are those that can conduct as well as metals. This discovery sparked a revolution in the electronics community, and three decades of research effort is now yielding a range of stunning new applications for this ubiquitous material.
Therapeutic Vaccination Refocuses T-cell Responses Towards Conserved Regions of HIV-1 in Early Treated Individuals (BCN 01 study) (2019)

Evidence Before this Study: T cells play an important role in the control of HIV infection and may be particularly useful for HIV-1 cure by killing cells with reactivated HIV-1. Evidence is emerging that not all T-cell responses are protective and mainly only those targeting conserved regions of HIV-1 proteins are effective, but typically immunologically subdominant, while those recognizing hypervariable, easy-to-escape immunodominant 'decoys' do not control viremia and do not protect from a loss of CD4 T cells. We pioneered a vaccine strategy focusing T-cell responses on the most conserved regions of the HIV-1 proteome using an immunogen designated HIVconsv. T cells elicited by the HIVconsv vaccines in HIV-uninfected UK and Kenyan adults inhibited in vitro replication of HIV-1 isolates from 4 major global clades A, B, C and D.Added Value of this Study: The present study demonstrated the concept that epitopes subdominant in natural infection, when taken out of the context of the whole HIV-1 proteome and presented to the immune system by a potent simian adenovirus prime-poxvirus MVA boost regimen, can induce strong responses in patients on antiretroviral treatment and efficiently refocus HIV-1-specific T-cells to the protective epitopes delivered by the vaccine.Implications of all the Available Evidence: Nearly all HIV-1 vaccine strategies currently emphasize induction of broadly neutralizing Abs. The HIVconsv vaccine is one of a very few approaches focussing exclusively on elicitation of T cells and, therefore, can complement antibody induction for better prevention and cure. Given the cross-clade reach on the HIVconsv immunogen design, if efficient, the HIVconsv vaccines could be deployed globally. Effective vaccines will likely be a necessary component in combination with other available preventive measures for halting the HIV-1/AIDS epidemic.
ON THE QUENCHING OF SINGLET OXYGEN BY α‐TOCOPHEROL (1974)

Abstract —D‐α‐tocopherol was found to be an effective quencher of 1 O 2 molecules ( k = 2.5 times 10 8 →mol ‐1 s ‐1 in pyridine) by measuring its effect on the autosensitized photooxidation of rubrene. The quenching process was shown to be almost entirely ‘physical’, that is, α‐tocopherol deactivated about 120 1 O 2 molecules before being destroyed. The results suggest that this process may be a mechanism for the protective effect of α ‐ tocopherol in photodynamic action.
A Tip-Extending Soft Robot Enables Reconfigurable and Deployable Antennas (2018)

Antennas are essential in wireless communications and powering systems. Applications, such as search and rescue and space exploration would greatly benefit from antenna reconfigurability, as well as antenna deployment from a compact and easy-to-transport form. We present the design and analysis of a reconfigurable and deployable antenna that uses a growing soft robot to form the three-dimensional antenna structure. Our approach is based on a pneumatic tip-extending robot instrumented with a conducting element. The robot increases its length to enable antenna deployment and changes shape to enable antenna reconfiguration. As a model system, we demonstrate a monopole antenna design that uses conducting elements formed from a copper strip that is mechanically disconnected at the leading edge of growth to change the length of the antenna and, as a result, change the resonant frequency. To achieve desired operating frequencies, return loss data from the antenna was used as feedback in a closed-loop system to control the antenna configuration. Our monopole supports a frequency tuning range that spans from 0.4 to 2 GHz and can tune between two target frequencies in approximately one second. We also show that the addition of branching and integrated actuators can be used to generate more complex and diverse antenna shapes. Branching is implemented in a model Yagi-Uda antenna and we explore the integration of pull cable actuators and pneumatic actuators with a model helical antenna.
Genetics of attention deficit/hyperactivity disorder: Are we ready for molecular genetic studies? (2000)

Reports of possible genetic associations or linkages for attention deficit hyperactivity disorder are appearing at an increasing rate. As with many other neuropsychiatric disorders, claims of positive findings are frequently followed by negative reports. In this review, the evidence underpinning genetic hypotheses for the origins of ADHD is reviewed with particular emphasis on what is the heritable phenotype. It is concluded that advances in identifying mutations or allelic variations in genes predisposing to ADHD are likely, but the general replication of such findings must await a better characterization of the heritable phenotypic elements of ADHD and a better understanding of its genetic heterogeneity.
Blockchain Meets Database: Design and Implementation of a Blockchain Relational Database (2019)

In this paper, we design and implement the first-ever decentralized replicated relational database with blockchain properties that we term blockchain relational database. We highlight several similarities between features provided by blockchain platforms and a replicated relational database, although they are conceptually different, primarily in their trust model. Motivated by this, we leverage the rich features, decades of research and optimization, and available tooling in relational databases to build a blockchain relational database. We consider a permissioned blockchain model of known, but mutually distrustful organizations each operating their own database instance that are replicas of one another. The replicas execute transactions independently and engage in decentralized consensus to determine the commit order for transactions. We design two approaches, the first where the commit order for transactions is agreed upon prior to executing them, and the second where transactions are executed without prior knowledge of the commit order while the ordering happens in parallel. We leverage serializable snapshot isolation (SSI) to guarantee that the replicas across nodes remain consistent and respect the ordering determined by consensus, and devise a new variant of SSI based on block height for the latter approach. We implement our system on PostgreSQL and present detailed performance experiments analyzing both approaches.
Sonic logging in deviated boreholes penetrating an anisotropic formation: Laboratory study (2007)

Abstract Development of deepwater fields requires drilling deviated or horizontal wells. Many formations are highly anisotropic, that is, the P- and S-wave velocities vary with propagation direction. Sonic logs acquired in these wells need to be corrected for anisotropy effects before the logs can be used in formation evaluation and seismic applications. In this study, we use a laboratory model made of an orthorhombic Phenolite block to study acoustic logging in deviated wells. We first measure the qP-, qSV-, and SH-wave group velocities by using body waves at angles of 0°, 15°, 30°, 45°, 60°, 75°, and 90° relative to the slowest P-wave principal axis of the Phenolite block. We then drill holes at the same angles in the block. We record monopole and dipole sonic waveforms in these holes and extract the qP-, qSV-, SH-, and Stoneley-wave velocities by using the slowness-time semblance method. The velocities measured through the use of monopole logging and dipole logging vary with borehole deviations. We find that an equivalent transversely isotropic (TI) model can fit the measured qP-, qSV-, and Stoneley-wave velocities very well. The S-wave velocities at low to medium borehole deviations can be used to differentiate an orthorhombic material from a TI one.
A hybrid wavelet convolution network with sparse-coding for image super-resolution (2016)

This paper proposes a hybrid wavelet convolution network (HWCN) which is composed of a scattering convolution component and a convolution neural component. The hierarchical end-to-end network implements sparse-coding and high-dimensional reconstruction for inverse problem through cascade convolutions. With the pre-defined scattering convolutions from nonlinear operators, the network can be tailored in accordance with the frequency property to provide sparse code candidates, and the convolution neural component could automatically select and weight these candidates for sparse coding. Given a tiny dataset, HWCN could train complex deep network with better generalization by regularization from scattering convolutions, and thereby is a competitive alternative to convolutional neural networks (CNN). Moreover, we further demonstrate that HWCN is a superior selection of sparse-coding based image super-resolution and achieves state-of-the-art performance.
p38α Isoform Mxi2 Binds to Extracellular Signal-Regulated Kinase 1 and 2 Mitogen-Activated Protein Kinase and Regulates Its Nuclear Activity by Sustaining Its Phosphorylation Levels (2003)

Mxi2 is a p38alpha splice isoform that is distinctively activated by mitogenic stimuli. Here we show that Mxi2 immunoprecipitates carry a kinase activity that is persistently activated by epidermal growth factor in a fashion regulated by Ras, Raf, and MEK. We demonstrate that this kinase activity can be attributed not to Mxi2 but rather to extracellular signal-regulated kinases 1 and 2 (ERK1/2), which coimmunoprecipitated with Mxi2 both by ectopic expression and in a physiological environment like the kidney. Furthermore, we provide evidence that Mxi2-ERK interaction has profound effects on ERK function, demonstrating that Mxi2 prolongs the duration of the ERK signal by sustaining its phosphorylation levels. Interestingly, we show that the effects of Mxi2 on ERK are restricted to nuclear events. Mxi2 potently up-regulates ERK-mediated activation of the transcription factors Elk1 and HIF1alpha but has no effect on the activity of ERK cytoplasmic substrates RSK2 and cPLA(2), induced by epidermal growth factor or by MEK. Overall, our findings point to Mxi2 as a unique member of the p38 family that may have an unprecedented role in the regulation of the functions of ERK mitogen-activated protein kinases.
Multimodal imaging of cutaneous wound tissue (2015)

Quantitative assessment of wound tissue ischemia, perfusion, and inflammation provides critical information for appropriate detection, staging, and treatment of chronic wounds. However, few methods are available for simultaneous assessment of these tissue parameters in a noninvasive and quantitative fashion. We integrated hyperspectral, laser speckle, and thermographic imaging modalities in a single-experimental setup for multimodal assessment of tissue oxygenation, perfusion, and inflammation characteristics. Algorithms were developed for appropriate coregistration between wound images acquired by different imaging modalities at different times. The multimodal wound imaging system was validated in an occlusion experiment, where oxygenation and perfusion maps of a healthy subject's upper extremity were continuously monitored during a postocclusive reactive hyperemia procedure and compared with standard measurements. The system was also tested in a clinical trial where a wound of three millimeters in diameter was introduced on a healthy subject's lower extremity and the healing process was continuously monitored. Our in vivo experiments demonstrated the clinical feasibility of multimodal cutaneous wound imaging.
The constitution, citizenship and ethnicity (1995)

Attempts to establish a unitary sense of Canadian citizenship through symbolic engineering at the constitutional level are self‐defeating. Canadians must accept that their only basis for a common ethnicity is their continuing engagement in the challenge of maintaining a political community in which they can accomplish significant civic tasks together while respecting their multiple identities.
Increasing the lateral resolution of 4Pi fluorescence microscopes (2006)

The axial resolution of fluorescence microscopes can be considerably improved by superposing two illumination beams and by adding coherently the two wavefronts emitted by the luminescent sample. This solution has been implemented in 4Pi microscopes. Theoretical and experimental results have shown that a considerable improvement of the axial resolution can be obtained with these microscopes. However, the lateral resolution remains limited by diffraction. We propose a configuration of a 4Pi microscope in which the lateral displacement of the source modifies the collection efficiency function (CEF). Numerical calculations based on an approximate scalar theory and on exact vector-wave-optics results of the field distribution of the electromagnetic field in image space show that the lateral extent of the CEF can be reduced by a factor greater than 2 with respect to the diffraction limit. We show that, with this solution, the resolution in the transverse plane of 4Pi type B and 4Pi type C microscopes can be improved significantly.