gebhart/patrepeval huggingface dataset:
Crystal Structure of the Chloroplastic Oxoene Reductase ceQORH from Arabidopsis thaliana (2017)

Enzymatic and non-enzymatic peroxidation of polyunsaturated fatty acids give rise to accumulation of aldehydes, ketones, and α,β-unsaturated carbonyls of various lengths, known as oxylipins. Oxylipins with α,β-unsaturated carbonyls are reactive electrophile species and are toxic. Cells have evolved several mechanisms to scavenge reactive electrophile oxylipins and decrease their reactivity such as by coupling with glutathione, or by reduction using NAD(P)H-dependent reductases and dehydrogenases of various substrate specificities. Plant cell chloroplasts produce reactive electrophile oxylipins named γ-ketols downstream of enzymatic lipid peroxidation. The chloroplast envelope quinone oxidoreductase homolog (ceQORH) from <i>Arabidopsis thaliana</i> was previously shown to reduce the reactive double bond of γ-ketols. In marked difference with its cytosolic homolog alkenal reductase (AtAER) that displays a high activity toward the ketodiene 13-oxo-9(Z),11(E)-octadecadienoic acid (13-KODE) and the ketotriene 13-oxo-9(Z), 11(E), 15(Z)-octadecatrienoic acid (13-KOTE), ceQORH binds, but does not reduce, 13-KODE and 13-KOTE. Crystal structures of apo-ceQORH and ceQORH bound to 13-KOTE or to NADP<sup>+</sup> and 13-KOTE have been solved showing a large ligand binding site, also observed in the structure of the cytosolic alkenal/one reductase. Positioning of the α,β-unsaturated carbonyl of 13-KOTE in ceQORH-NADP<sup>+</sup>-13-KOTE, far away from the NADP<sup>+</sup> nicotinamide ring, provides a rational for the absence of activity with the ketodienes and ketotrienes. ceQORH is a monomeric enzyme in solution whereas other enzymes from the quinone oxidoreductase family are stable dimers and a structural explanation of this difference is proposed. A possible <i>in vivo</i> role of ketodienes and ketotrienes binding to ceQORH is also discussed.
Clotting Mimicry from Robust Hemostatic Bandages Based on Self-Assembling Peptides (2015)

Uncontrolled bleeding from traumatic wounds is a major factor in deaths resulting from military conflict, accidents, disasters and crime. Self-assembling peptide nanofibers have shown superior hemostatic activity, and herein, we elucidate their mechanism by visualizing the formation of nanofiber-based clots that aggregate blood components with a similar morphology to fibrin-based clots. Furthermore, to enhance its direct application to a wound, we developed layer-by-layer assembled thin film coatings onto common materials used for wound dressings-gauze and gelatin sponges. We find these nanofibers elute upon hydration under physiological conditions and generate nanofiber-based clots with blood. After exposure to a range of harsh temperature conditions (-80 to 60 °C) for a week and even 5 months at 60 °C, these hemostatic bandages remain capable of releasing active nanofibers. In addition, the application of these nanofiber-based films from gauze bandages was found to accelerate hemostasis in porcine skin wounds as compared to plain gauze. The thermal robustness, in combination with the self-assembling peptide's potent hemostatic activity, biocompatibility, biodegradability, and low cost of production, makes this a promising approach for a cheap yet effective hemostatic bandage.
The metabolism of malondialdehyde (1986)

Interest in malondialdehyde (MDA) metabolism stems from its formation as a product of lipid peroxidation in the diet and in the tissues; its reactivity with functional groups of nucleic acid bases, proteins and phospholipids; its mutagenicity in bacteria, and its reported skin and liver carcinogenicity in animals. Administration of the Na enol salt of MDA in the drinking water of mice over a range of 0.1-10.0 micrograms/g/day for 12 mo produced dose-dependent hyperplastic and neoplastic changes in liver nuclei and increased mortality at the highest level but produced no gross hepatic tumors. Addition of MDA to the medium of rat skin fibroblasts grown in culture caused nuclear abnormalities at concentrations as low as 10(-6) M despite an uptake of only 4%. [1,3-14C]MDA was rapidly oxidized to [14C]acetate in rat liver mitochondria and to 14CO2 in vivo; however, approximately 10% of the radioactivity was recovered in the urine. Chromatographic analysis of rat urine revealed the presence of several compounds which yield MDA on acid hydrolysis. Total MDA excretion increased in response to conditions which stimulate lipid peroxidation in vivo, including vitamin E deficiency, Fe or CCl4 administration, and enrichment of the tissues with PUFA. N-acetyl-e-(2-propenal)lysine was identified as a major urinary metabolite of MDA in rat and human urine. This compound is derived primarily from N-alpha-(2-propenal)lysine released in digestion as a product of reactions between MDA and the epsilon-amino groups of N-terminal lysine residues in food proteins. However, its presence in the urine of animals fasted or fed MDA-free diets indicates that it is also formed in vivo.(ABSTRACT TRUNCATED AT 250 WORDS)
Cross-In-Hand (1926)

Journal Article Cross-In-Hand Get access F. E. H. F. E. H. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CLI, Issue jul24, 24 July 1926, Page 66, https://doi.org/10.1093/nq/CLI.jul24.66 Published: 24 July 1926
Maintaining the time in a distributed system (1983)

To a client of a loosely-coupled distributed system, one of the simplest services is a time service. Usually the client simply requests the time from any subset of the time servers making up the service, and uses the first reply. Issues that need to be considered in other services, such as connection establishment or client authentication, need not be considered in a time service. The simplicity of this instruction, however, misrepresents the complexity of implementing such a service.
TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development (2008)

Hypoxia is a microenvironmental factor which plays a critical role in development and tumor progression. The hypoxic response is mainly mediated by hypoxia inducible factor-1 (HIF-1) composed of HIF-1alpha and HIF-1beta, which becomes active under low oxygen condition. HIF-1 activates the transcription of hypoxia inducible genes which regulate diverse cellular functions including metabolism, angiogenesis and invasion. In cancer metastasis, HIF-1-regulated genes promote angiogenesis, invasion and epithelial-mesenchymal transition (EMT), a critical step of metastasis. TWIST is a master regulator of gastrulation and mesoderm specification and is recently implicated to be essential to mediate cancer metastasis. We recently showed that HIF-1 promotes EMT through direct regulation of TWIST expression. TWIST is critical for hypoxia mediated EMT and metastasis. TWIST plays a non-redundant role in relation to other EMT regulators (e.g., Snail) under hypoxia. Co-expression of HIF-1alpha, TWIST and Snail could be used as a prognostic marker in cancer patients. These findings suggest that hypoxia and/or HIF-1 orchestrates EMT and metastasis through the coordinated regulation of different EMT regulators. Our results provide the important link between hypoxia and developmental processes regulated by TWIST. The implications of the roles of hypoxia and TWIST in early embryonic development are discussed.
All-Nb low-noise dc SQUID with 1-μm tunnel junctions (1980)

Tunnel-junction dc SQUIDs are being fabricated from Nb films using electron-beam lithography to define linewidths as small as 0.5 μm. The barriers in the Nb-NbOx-Nb junctions are grown in an oxygen plasma discharge, and the Pd2Si resistive shunts are formed by annealing Pd on the Si substrates. These devices have excellent storage and recycling properties. At a measurement frequency of 40 kHz, a SQUID with an inductance of about 1 nH, a critical current of about 4 μA, and a parallel shunt resistance of about 15 Ω had an intrinsic energy resolution of 2.5×10−32 J Hz−1 at 4.2 K and 1.1×10−32 J Hz−1 at 1.6 K, in good agreement with a model of the dc SQUID.
Single-channel multiplexing without melting curve analysis in real-time PCR (2014)

Multiplex real-time PCR with quantification of targets in a single fluorescence channel has been the demand in biotechnology industry. Here, we develop a novel analytical real-time PCR technique to detect multiple targets in a single fluorescence channel without melting curve analysis. In this technique, we show the intensity of the fluorescence signals of two discrete Tm targets is different at certain temperatures called detection temperatures, by which a high Tm target can be detected regardless of a low Tm target. We then identify the low Tm target by utilizing a change of the fluorescence signals between two different detection temperatures. Furthermore, it enables us to determine quantification of each target in a single channel, possibly facilitating convenient patient care for drug treatment in clinics.
Autism: Towards an Integration of Clinical, Genetic, Neuropsychological, and Neurobiological Perspectives (1996)

Autism constitutes one of the best validated child psychiatric disorders. Empirical research has succeeded in delineating the key clinical phenomena, in demonstrating strong genetic influences on the underlying liability, and in identifying basic cognitive deficits. A range of neurobiological abnormalities has also been found, although the replicability of specific findings has not been high. An understanding of the causal processes leading to autism, and accounting for the marked variability in its manifestations, requires an integration across these different levels of enquiry. Although this is not yet possible, a partial integration provides a useful strategy for identifying key research questions, the limitations of existing hypotheses, and future research directions that are likely to prove fruitful. The research findings for each research level are critically reviewed in order to consider how to move towards an integration across levels.
Nanoliquid chromatography‐mass spectrometry of oligosaccharides employing graphitized carbon chromatography on microchip with a high‐accuracy mass analyzer (2005)

The nanoLC separations of oligosaccharides using microchip-based columns are described. Mixtures of alditols from mucins and human milk are separated on graphitized carbon. The nanoLC-MS device showed high mass accuracy for the oligosaccharides ranging between 1 and 6 ppm on routine analyses. The high mass accuracy readily allowed identification of oligosaccharide peaks and the determination of their compositions. High retention time reproducibility was exhibited by the microchip LC. Little variation was observed for standard sample either alone or in a complex heterogeneous mixture. The nanoLC-MS exhibits excellent capabilities in profiling mixtures of oligosaccharides.
Synthesis and Characterization of Yttrium Complexes Containing a Tridentate Linked Amido−Cyclopentadienyl Ligand (1998)

The reaction of dilithium salts of the tridentate linked amido−cyclopentadienyl ligands Li2(C5Me4SiMe2NCH2CH2X) (X = OMe, NMe2, CH2OMe) with [Y(o-C6H4CH2NMe2)Cl2(LiCl)(THF)4] and Y(η5-C5H5)Cl2(THF)3 give chloro-bridged ate complexes of the type [Li(THF)][Y(η5:η1-C5Me4SiMe2NCH2CH2X)(R)Cl], where R = o-C6H4CH2NMe2, η5-C5H5.
A selective temporal and aggressive spatial cache system based on time interval (2002)

This paper proposes a new cache system that can increase the effect by temporal and spatial locality by using only simple hardware control without any locality detection hardware or compiler aid. The proposed cache system consists of two caches with different associativities and different block sizes, i.e., a direct-mapped cache with small block size and a fully associative spatial buffer with large block size as a multiple of small blocks. Therefore, the spatial locality can be exploited by aggressively fetching large blocks including any missed small block into the buffer, and the temporal locality can also be exploited by selectively storing small blocks that were referenced at the spatial buffer in the past. To determine the blocks to be stored at the direct-mapped cache, the proposed cache system uses a time interval-based selection mechanism. According to the simulation results, similar performance can be achieved by using four times smaller cache size compared with the conventional direct-mapped cache.
Multiple, reversible chlorination of C60 (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple, reversible chlorination of C60Fred N. Tebbe, James Y. Becker, D. Bruce Chase, Lawrence E. Firment, Edward R. Holler, Brian S. Malone, Paul J. Krusic, and E. WassermanCite this: J. Am. Chem. Soc. 1991, 113, 26, 9900–9901Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ja00026a052https://doi.org/10.1021/ja00026a052research-articleACS PublicationsRequest reuse permissionsArticle Views377Altmetric-Citations122LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bulk and physical properties of needle-punched nonwoven fabrics (2005)

Bulk and physica l properti es of need le-punched nonwoven fabri c depend on the nature of component fibre, the manner in whi ch the fibres arc arranged in the struc ture and the degree of co nsolidation . A proper understanding of th.:. role of differe nt parameters on fabr ic properties is important l'o r des igning the fabric sui table for its use. Normall y, the longer and finer fibre in the web leads to greater fabri c strength , prov ided the fibre brea kage is contro lled. The increase in needle density and penetrat ion improves the fibre conso lidation. but beyond a certain limit the fibre damage becomes greater, leading to deteriorati on in fabric characteri stics. Highcr fab ri c weig ilt and introduc ti on of scrim generall y improve the functi onal propeni es of fabri c. Fin ishing operation is opted in the cases where some spec ial requirements are to be fulfi lled. Thi s paper is intended to develop some understandi ng about thc bu lk and phys ical propert ies in relation to raw material, machine parameters and process va riables.
Performance evaluation of the Mojette erasure code for fault-tolerant distributed hot data storage (2015)

Packet erasure codes are today a real alternative to replication in fault tolerant distributed storage systems. In this paper, we propose the Mojette erasure code based on the Mojette transform, a formerly tomographic tool. The performance of coding and decoding are compared to the Reed-Solomon code implementations of the two open-source reference libraries namely ISA-L and Jerasure 2.0. Results clearly show better performances for our discrete geometric code compared to the classical algebraic approaches. A gain factor up to $2$ is measured in comparison with the ISA-L Intel . Those very good performances allow to deploy Mojette erasure code for hot data distributed storage and I/O intensive applications.
RTSTREAM: Real-Time Query Processing for Data Streams (2006)

Many real-time applications, such as traffic control systems, surveillance systems and health monitoring systems, need to operate on continuous unbounded streams of data. These applications also have inherent real-time performance requirements that have to be met under high-volume, time-varying incoming data streams. In this paper, we present a real-time data stream query model named PQuery, which provides periodic real-time queries on data streams for the aforementioned real-time applications. To support the PQuery model, a real-time data stream management prototype system named RTSTREAM is developed to provide deadline miss ratio guarantees for periodic queries over continuous and unbounded data streams. We describe the periodic query semantics and discuss why the periodic query model is appropriate for real-time applications. To handle irregular data arrival patterns and query workloads, we propose data admission as an overload protection mechanism. We conduct performance studies with synthetic workloads as well as real workloads from network traffic monitoring applications. The experimental results show that the proposed periodic query model suits the need of the real-time applications and the data admission overload protection approach is effective in managing the workload fluctuations.
Ni–NiO core–shell inverse opal electrodes for supercapacitors (2011)

A general template-assisted electrochemical approach was used to synthesize three-dimensional ordered Ni core-NiO shell inverse opals (IOs) as electrodes for supercapacitors. The Ni-NiO IO electrodes displayed pseudo-capacitor behavior, good rate capability and cycling performance.
6.2: Biaxial Strength of Ultrathin AMLCD Glass Substrates (2002)

Abstract The biaxial strength of ultrathin AMLCD glass substrates with thickness ranging from 0.25mm to 0.70mm was measured in the concentric ring fixture. The data, based on a large sample size of 25mm × 25mm square specimens, show that the strength is independent of glass thickness and approaches 630 MPa. The choice of 25mm × 25mm specimens for measuring the biaxial strength was dictated by minimizing large deflections and associated membrane tension in the test region. The effect of surface area under test was taken into account by using Weibull distribution which demonstrated constancy of surface strength irrespective of substrate thickness. Thus, thin and ultrathin AMLCD susbtrates have similar biaxial strength as measured in the concentric ring fixture.
Continuous Range Search Query Processing in Mobile Navigation (2008)

Range search query processing has become one of the most important technologies in spatial and mobile databases. Most literature focuses on static range search extended from one point on both Euclidean distance and actual network distance, but there are only a few methods which can properly solve the problem for moving users, such as searching objects of interest on a road within a certain range. Although there are some techniques, which address continuous search, most approaches are absorbed in the KNN (k nearest neighbour) queries which are a different research area. In this paper, we propose two new methods to process continuous range search query in mobile computing. One is constructed using R-tree index based on Euclidean distance, and the other addresses the requirement on actual network distance.
Interaction of Cyclodextrin-Containing Polymers with Fluorescent Compounds (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteraction of Cyclodextrin-Containing Polymers with Fluorescent CompoundsAkira Harada, Masaoki Furue, and Shun-ichi NozakuraCite this: Macromolecules 1977, 10, 3, 676–681Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://pubs.acs.org/doi/10.1021/ma60057a036https://doi.org/10.1021/ma60057a036research-articleACS PublicationsRequest reuse permissionsArticle Views505Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A review of residual stress distributions in welded joints for the defect assessment of offshore structures (1998)

A review of residual stress distributions in welded joints and the treatment of residual stresses in defect assessment procedures is presented. A review of the literature has been carried out on residual stress distributions in welded joints, with particular emphasis on offshore structures, in order to identify representative distributions. Consideration has also been given to the current methods for the treatment of residual stress in defect assessment procedures, such as British Standard PD 6493:1991 and the Nuclear Electric R6 procedure, and the methods for measuring residual stresses. Areas of further work have been identified for establishing a comprehensive catalogue of stress distributions. (author)
The research on virtual simulation of lead screw system (2016)

In the process of development of numerical control system, we would actually go to the processing plant to test a strategy or compare the accuracy of trajectory planning, which is not only inefficient, but may lead to mechanical platform damage or safety incidents due to improper use of the parameters. Therefore, we aim to establish virtual simulation system for the lead screw guide system. Based on the process of CNC machining process, a whole architecture of virtual simulation platform is put forward. Virtual simulation platform can be divided into specific modules, including trajectory planning module,control module, single axis platform module, error analysis module and compensation module. We analyze the mathematical modeling based on a XY table. In order to reflect the characteristics of the system, we mainly focus on the reverse gap, friction force and other nonlinear factors analysis and modeling. We establish the model of a servo drive and mechanical structure. Finally, based on the simulation platform, we add the compensation control module to the virtual simulation system. By comparing contour error of experimental platform and simulation platform before and after compensation, we prove that the compensation is effective.
On a model for storage and search (1973)

Books are arranged on a shelf. After use, a book is returned to the left hand end of the shelf. Expressions are derived for the probability that, in equilibrium, a given book is in a given position on the shelf, in terms of the frequencies with which the different books are demanded.
Piezooptic behavior of certain fluids (1985)

In this paper we present an analysis of pressure-volume data for certain optical fluids, which characterizes them by two parameters: their bulk moduli and the pressure derivative of their bulk moduli, both evaluated at zero pressure. We then relate their refractive-index changes to density and pressure using this analysis and the Lorentz-Lorenz equation with a density-dependent polarizability. An example of the use of such fluids in a fiber-optic pressure gauge being developed at Sandia is also discussed.