gebhart/patrepeval huggingface dataset:
Transport of Biosynthetic Intermediates: Homoserine and Threonine Uptake in <i>Escherichia coli</i> (1974)

Although amino acid transport has been extensively studied in bacteria during the past decade, little is known concerning the transport of those amino acids that are biosynthetic intermediates or have multiple fates within the cell. We have studied homoserine and threonine as examples of this phenomenon. Homoserine is transported by a single system which it shares with alanine, cysteine, isoleucine, leucine, phenylalanine, threonine, tyrosine, and valine. The evidence for this being the sole system for homoserine transport is (i) a linear double-reciprocal plot showing a homoserine K(m) of 9.6 x 10(-6) M, (ii) simultaneous reduction by 85% of homoserine and branched-chain amino acid uptake in a mutant selected for its inability to transport homoserine, and (iii) simultaneous reduction by 94% of the uptake of homoserine and the branched-chain amino acids by cells grown in millimolar leucine. Threonine, in addition to sharing the above system with homoserine, is transported by a second system shared with serine. The evidence for this second system consists of (i) incomplete inhibition of threonine uptake by any single amino acid, (ii) only 70% loss of threonine uptake in the mutant unable to transport homoserine, and (iii) only 40% reduction of threonine uptake when cells are grown in millimolar leucine. In this last case, the remaining threonine uptake can only be inhibited by serine and the inhibition is complete.
Size-dependent light output, spectral shift, and self-heating of 400 nm InGaN light-emitting diodes (2010)

We have systematically investigated the impact of device size scaling on the light output, spectral shift, and self-heating of 400 nm InGaN light-emitting diodes (LEDs). Devices with diameters in the range 20–300 μm have been studied. It is shown that smaller LED pixels can deliver higher power densities (despite the lower absolute output powers) and sustain higher current densities. Investigations of the electroluminescence characteristics of differently sized pixels against current density reveal that the spectral shift is dominated by blueshift at the low current density level and then by redshift at the high current density level, owing to the competition between the bandgap shrinkage caused by self-heating and band-filling effects. The redshift of the emission wavelength with increasing current density is much faster and larger for the bigger pixels, suggesting that the self-heating effect is also size dependent. This is further confirmed by the junction-temperature rise measured by the established spectral shift method. It is shown that the junction-temperature rise in smaller pixels is slower, which in turn explains why the smaller redshift of the emission wavelength with current density is present in smaller pixels. The measured size-dependent junction temperature is in reasonable agreement with finite element method simulation results.
Size-based Transfer Functions: A New Volume Exploration Technique (2008)

The visualization of complex 3D images remains a challenge, a fact that is magnified by the difficulty to classify or segment volume data. In this paper, we introduce size-based transfer functions, which map the local scale of features to color and opacity. Features in a data set with similar or identical scalar values can be classified based on their relative size. We achieve this with the use of scale fields, which are 3D fields that represent the relative size of the local feature at each voxel. We present a mechanism for obtaining these scale fields at interactive rates, through a continuous scale-space analysis and a set of detection filters. Through a number of examples, we show that size-based transfer functions can improve classification and enhance volume rendering techniques, such as maximum intensity projection. The ability to classify objects based on local size at interactive rates proves to be a powerful method for complex data exploration.
Real-time detection of linear and angular displacements with a modified DVD optical head (2008)

Here we demonstrate that an astigmatic detection system (ADS), constructed with a modified digital-versatile-disk (DVD) optical head, can achieve real-time measurement of a linear displacement and two-dimensional (2D) tilt angles with a high sensitivity. An atomic force microscope (AFM), using our detection system to sense the deflection of microfabricated cantilevers, can resolve single atomic steps on graphite surfaces with a noise level less than 0.04 nm in topographic images. This astigmatic detection system can even detect mechanical resonances due to thermal vibrations of microfabricated cantilevers. The high sensitivity, small detecting size and high bandwidth of this detection system is suitable for dynamic characterization of elements in micromachined components. Further optimization of the system will promise many other applications in diverse technological fields.
Nickel Mirror And Supermirror Neutron Guide Tubes At The Kyoto University Research Reactor (1989)

We installed the first nickel mirror neutron guide tube with a characteristic wavelength of 2.85 Å at Kyoto University research reactor(KUR, 5MW, cooled and moderated by light water) in 1973 and a supermirror guide tube with a characteristic wavelength of 1.17 Å in 1984, in order to get more intense thermal neutron beam. Four guide tubes are under construction at a cold neutron source installed in 1986. Two of them are supermirror type with a characteristic wavelength of 3 Å and the others are supermirror and Ni-mirror type with characteristic wavelengths of 6 Å and 23 Å, respectively. Supermirrors are made by automatically controlled vacuum deposition of nickel and titanium metal with electron gun. Their averaging reflectivity for the first supermirror guide tube are the following: The apparent critical wavelength, λ/θ, of reflection is 240 Å in term of wavelength(λ/θ) corresponding to the component of wave number perpendicular to the mirror surface. The reflectivity is 0.65 at the apparent critical wavelength and becomes higher with increasing neutron wavelength up to nearly unity for wavelength longer than 500 Å. Supermirror guide tubes are featured by more available neutrons with larger divergent angles and shorter length of the guide tubes. These features would bring us significant advantages depending on experimental requirements.
Apartheid in Australia: A newly-discovered document (1995)

As late as 1965 the Australian government gave consideration to a policy which would have established special areas of residence for Aboriginal people. A plan to effect this was drawn up for the Minister for Aboriginal Affairs. The document does not carry the author's name, but internal evidence points to a non-Australian resident, possibly a South African.
Antimicrobial treatment of Erysipelatoclostridium ramosum invasive infections: a systematic review (2021)

The aim of this systematic review was to determine the causal role of Erysipelatoclostridium ramosum in specific invasive infections in humans, and to assess the clinical outcome of antibiotic therapy used to treat them. Several electronic databases were systematically searched for clinical trials, observational studies or individual cases on patients of any age and gender with a systemic inflammatory response syndrome (SIRS) due to E. ramosum isolated from body fluids or tissues in which it is not normally present. Only reports identifying E. ramosum as the only microorganism isolated from a patient with SIRS were included. This systematic review included 15 studies reporting 19 individual cases in which E. ramosum caused invasive infections in various tissues, mainly in immunocompromised patients. E. ramosum was most often isolated by blood cultures and identified by specific biochemical tests. Severe infections caused by E. ramosum were in most cases effectively treated with antibiotics, except in two patients, one of whom died. More than one isolate of E. ramosum exhibited 100% susceptibility to metronidazole, amoxicillin/clavulanate and piperacillin/tazobactam. On the other hand, individual resistance of this bacterium to penicillin, ciprofloxacin, clindamycin, imipenem and ertapenem was reported. This systematic review confirmed the clinical relevance of E. ramosum as a cause of a number of severe infections mainly in immunocompromised inpatients. Metronidazole and meropenem appear to be the antibiotics of choice that should be used in combination or as monotherapy to treat E. ramosum infections, depending on the type and severity of the infection.
Techniques to improve memory interface test quality for complex SoCs (2011)

Aggressive speed and voltage binning schemes are widely used in the industry to improve the yield of SoCs. For accurate bin classification, it is essential that the tests used for binning target the worst critical/speed-limiting paths in the design. We have observed in many SoCs that memory interface paths are amongst the top critical paths. In this paper, we propose new DFT schemes to improve the quality of memory interface logic test. We also discuss practical challenges and propose solutions for successfully implementing ATPG on memory-interface paths of large SoCs. Experimental results on 40nm industrial designs show an average increase of 36% memory interface fault coverage. Fmax result from production SoC silicon establishes the effectiveness of the proposed scheme for speed binning.
Matrix multiplication via arithmetic progressions (1987)

We present a new method for accelerating matrix multiplication asymptotically. This work builds on recent ideas of Volker Strassen, by using a basic trilinear form which is not a matrix product. We make novel use of the Salem-Spencer Theorem, which gives a fairly dense set of integers with no three-term arithmetic progression. Our resulting matrix exponent is 2.376.
Child Art Therapy and Parent Consultation: Facilitating Child Development and Parent Strengths (2000)

Abstract This paper explores outpatient child art therapy methodology which emphasizes reinforcing parents' strengths, solidifying parentchild bonds, and using child artistic creativity as means of overcoming obstacles to healthy child development. The theoretical framework integrates D.W. Winnicott's (1971) model of parent consultation, child art therapy theories, and contemporary theories of child and brief psychotherapy. A short-term case study illustrates effective symptom management. A longer term case example demonstrates structural change within both the child and the parent-child bond.
Prostaglandin E receptor subtypes involved in stimulation of gastroduodenal bicarbonate secretion in rats and mice. (1999)

We investigated prostaglandin E (EP) receptor subtypes responsible for the HCO3- stimulatory action of prostaglandin E2 (PGE2) in the gastroduodental mucosa, by examining the effects of various prostanoids with subtype specific EP receptor agonists in rats and those of PGE2 in knockout mice lacking EP1 or EP3 receptors. In rats, gastric HCO3- secretion was stimulated by i.v. administration of PGE2, 17-phenyl PGE2 the selective EP1 agonist as well as sulprostone the EP1 and EP3 agonist, but was not affected by other EP agonists such as butaprost the selective EP2 agonist, ONO-NT-012 the selective EP3 agonist or 11-deoxy PGE1 the EP3 and EP4 agonist. In contrast, the HCO3- secretion in rat duodenums was stimulated by PGE2, sulprostone, ONO-NT-012 as well as 11-deoxy PGE1 but not affected by either 17-phenyl PGE2 or butaprost. The HCO stimulatory effect of sulprostone in the stomach was significantly inhibited by ONO-AE-829, the selective EP1 antagonist. On the other hand, PGE2 applied topically to the mucosa for 10 min caused a dose-dependent increase of HCO3- secretion in both the stomach and duodenum of wild-type mice. The HCO3- stimulatory action of PGE2 in the stomach was also observed dose-dependently in knockout mice lacking EP3-receptors but was absent in EP1-receptor knockout mice, while the stimulatory effect in the duodenum was observed in EP1-receptor knockout mice, similar to wild-type animals, but not in knockout mice lacking EP3-receptors. These results indicate that PGE2 stimulates HCO3- secretion via different EP receptor subtypes in the stomach and duodenum; the former is mediated by EP1-receptors, while the latter mediated by EP3-receptors.
An Architectural Framework for Accurate Characterization of Network Traffic (2008)

In networks carrying large volume of traffic, accurate traffic characterization is necessary for understanding the dynamics and patterns of network resource usage. Previous approaches to flow characterization are based on random sampling of the packets (e.g., Cisco's NetFlow) or inferring characteristics solely based on long lived flows (LLFs) or on lossy data structures (e.g., bloom filters, hash tables). However, none of these approaches takes into account the heavy-tailed nature of the Internet traffic and separates the estimation algorithm from the flow measurement architecture.In this paper, we propose an alternate approach to traffic characterization by closely linking the flow measurement architecture with the estimation algorithm. Our measurement framework stores complete information related to short lived flows (SLFs) while collecting partial information related to LLFs. For real-time separation of LLFs and SLFs, we propose a novel algorithm based on typical sequences from information theory. The distribution (pdf) and sample space of the underlying traffic is estimated using the non-parametric Parzen window technique and likelihood function defined over the Coupon collector problem. We validate the accuracy and performance of our estimation technique using traffic traces from the internal LAN in our laboratory and from National Library for Applied Network Research (NLANR).
Adaptation of commensal proliferating <i>Escherichia coli</i> to the intestinal tract of young children with cystic fibrosis (2018)

The mature human gut microbiota is established during the first years of life, and altered intestinal microbiomes have been associated with several human health disorders. Escherichia coli usually represents less than 1% of the human intestinal microbiome, whereas in cystic fibrosis (CF), greater than 50% relative abundance is common and correlates with intestinal inflammation and fecal fat malabsorption. Despite the proliferation of E. coli and other Proteobacteria in conditions involving chronic gastrointestinal tract inflammation, little is known about adaptation of specific characteristics associated with microbiota clonal expansion. We show that E. coli isolated from fecal samples of young children with CF has adapted to growth on glycerol, a major component of fecal fat. E. coli isolates from different CF patients demonstrate an increased growth rate in the presence of glycerol compared with E. coli from healthy controls, and unrelated CF E. coli strains have independently acquired this growth trait. Furthermore, CF and control E. coli isolates have differential gene expression when grown in minimal media with glycerol as the sole carbon source. While CF isolates display a growth-promoting transcriptional profile, control isolates engage stress and stationary-phase programs, which likely results in slower growth rates. Our results indicate that there is selection of unique characteristics within the microbiome of individuals with CF, which could contribute to individual disease outcomes.
Interacting with a Robot Ecology using Task Templates (2007)

Robot ecologies provide a new paradigm for assistive, service, industrial, and entertainment robotics which is quickly gaining popularity. These ecologies contain a large number of robotic components pervasively embedded in the environment and interacting with each other. Human users of such systems need to be able to interface with both the system as a w hole and, if desired, which each individual component. The humans should be able to transmit, in a natural way, commands that range from basic ones, such as "turn on the lights in the bedroom", to abstract ones, such as "bring me a cup of coffee". Human users may also need to interact with task execution, especially at decision points. In this paper, we introduce an approach to interface a human user to a specific type of robot ecology, called an ecology of Physically Embedded Intelligent Systems, or PEIS-Ecology. The ecology includes simple sensors and actuators and more complicated devices such as mobile robots. The proposed interface satisfies two requirements: 1) to easily and automatically generate component interfaces, and 2) to provide a simple mechanism by which to request and monitor the execution of tasks in the ecology.
Cobalt-mediated radical reactions in organic synthesis. Oxidative cyclisations of aryl and alkyl halides leading to functionalised reduced heterocycles and butyrolactones (1990)

Reactions between the CoI species derived from cobalt (III) salen (11) or cobalt(II) salophen (12) and (O-allyl) or (O-but-3-enyl) iodophenols lead to isolatable cobalt complexes, viz.(16) and (27), which can be converted into substituted benzofurans, i.e.(17) and (23), and benzopyrans, i.e.(28) and (34); similarly, interaction between compound (36) and CoI salen led in one step to 1,3-dimethyl-indole (37). Radical cyclisation of the acetal (38a) in the presence of CoI cobaloxime [from (10)] leads to the cis-ring-fused alkyl cobalt complex (42), which can be converted in a preparative manner into lactone (44) following 1,2-elimination [to (43)] and hydrolysis/oxidation, and into lactone (53) following insertion of molecular oxygen [to (50)], reduction [to (51)] and hydrolysis/oxidation.
Co-sensitization of Organic Dyes for Efficient Ionic Liquid Electrolyte-Based Dye-Sensitized Solar Cells (2007)

The co-sensitization of two organic dyes (SQ1 and JK2), which are complementary in their spectral responses, shows enhanced photovoltaic performance compared with that of an individual organic dye-sensitized solar cell. The power conversion efficiency of the co-sensitized organic dye solar cell based on the newly developed binary ionic liquid (solvent-free) electrolyte gives 6.4% under AM 1.5 sunlight at 100 mW/cm2 irradiation, which is higher than that of individual dye-sensitized solar cells. The incident monochromatic photon-to-current conversion efficiency (IPCE) of the co-sensitized solar cell shows typical absorption peaks at 530 and 650 nm corresponding to the two dyes and displays a broad spectral response over the entire visible spectrum with IPCE of >40% in the 400-700 nm wavelength domain.
Lactose tolerance in lambs with rotavirus diarrhoea. (1981)

It has been suggested that lactose malabsorption is an important factor in producing the diarrhoea of acute rotavirus infection. Accordingly, the lactose tolerance of gnotobiotic newborn lambs, infected with lamb rotavirus, has been investigated by clinical studies and tissue enzyme assays. Although lactase activity is low in affected areas of the small intestine, rotavirus infected lambs are not lactose intolerant as assessed by the measurement of reducing substances in the faeces, or by the clinical effects and blood glucose levels after a 5.8 mmol (2 g)/kg lactose load on the second day post-infection. Lactose intolerance could be demonstrated by using extremely high (29.2 mmol (10 g)/kg) doses of lactose, three or four times the normal dietary lactose intake. These experiments suggest that lactose-containing feeds (such as maternal milk) are not necessarily contraindicated in patients or animals with rotavirus diarrhoea.
Synthesizing configuration file specifications with association rule learning (2017)

System failures resulting from configuration errors are one of the major reasons for the compromised reliability of today's software systems. Although many techniques have been proposed for configuration error detection, these approaches can generally only be applied after an error has occurred. Proactively verifying configuration files is a challenging problem, because 1) software configurations are typically written in poorly structured and untyped “languages”, and 2) specifying rules for configuration verification is challenging in practice. This paper presents ConfigV, a verification framework for general software configurations. Our framework works as follows: in the pre-processing stage, we first automatically derive a specification. Once we have a specification, we check if a given configuration file adheres to that specification. The process of learning a specification works through three steps. First, ConfigV parses a training set of configuration files (not necessarily all correct) into a well-structured and probabilistically-typed intermediate representation. Second, based on the association rule learning algorithm, ConfigV learns rules from these intermediate representations. These rules establish relationships between the keywords appearing in the files. Finally, ConfigV employs rule graph analysis to refine the resulting rules. ConfigV is capable of detecting various configuration errors, including ordering errors, integer correlation errors, type errors, and missing entry errors. We evaluated ConfigV by verifying public configuration files on GitHub, and we show that ConfigV can detect known configuration errors in these files.
Advanced Modeling of Production Induced Pressure Depletion and Well Spacing Impact on Infill Wells in Spraberry, Permian Basin (2018)

Abstract Since early 2016, commodity prices have been gradually increasing, and the Permian Basin has become the most active basin for unconventional horizontal well development. As the plays in the basin are developed, new infill wells are drilled near pre-existing wells (known as "parent wells"). The impact of pressure depletion caused by adjacent existing producers may have a larger role in the performance of these new infill wells. How the various well spacing impact with the degree of reservoir pressure depletion from parent well is more important than ever for operators to optimize the completion design. Through data analytics and comprehensive fracture/reservoir modeling this paper studies how changes in well spacing and proppant volume in the Spraberry, a main formation in the Permian Basin, will impact new infill well performance. The studies in this paper are focused on the Midland Basin. A public database was used to identify the number of parent and child wells in the Midland basin. Data analysis of production normalized by total proppant and lateral length shows that parent wells outperform infill, or child, wells. To further understand the relationship between parent and child wells, a reservoir dataset for the Spraberry formation was used to build a hydraulic fracture and reservoir simulation model for both the parent well and a two-well infill pad. After production history matching a P50 type well as the parent well, three periods of production depletion were modeled (6 months, 3 years and 5 years) to understand the timing impact on the infill well production. A geomechanical finite-element model (FEM) was then used to quantify the changes to the magnitude and azimuth of the in-situ stresses from the various reservoir depletion scenarios. A two-well infill pad was then simulated into the altered stress field next to the parent well at various spacings between the parent and child wells. A sensitivity was then performed with different stimulation job sizes to understand the volume impact on created complex fracture propagation and total system recovery. This study can help operators understand how well spacing, reservoir depletion, and completion job size impact the infill well performance so they can optimize their infill well completion strategy.
Recent Advances in Silver‐Catalyzed Nitrene, Carbene, and Silylene‐Transfer Reactions (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.