gebhart/patrepeval huggingface dataset:
The β-Lactam Resistance Protein Blr, a Small Membrane Polypeptide, Is a Component of the Escherichia coli Cell Division Machinery (2012)

In Escherichia coli, cell division is performed by a multimolecular machinery called the divisome, made of 10 essential proteins and more than 20 accessory proteins. Through a bacterial two-hybrid library screen, we identified the E. coli β-lactam resistance protein Blr, a short membrane polypeptide of 41 residues, as an interacting partner of the essential cell division protein FtsL. In addition to FtsL, Blr was found to associate with several other divisomal proteins, including FtsI, FtsK, FtsN, FtsQ, FtsW, and YmgF. Using fluorescently tagged Blr, we showed that this peptide localizes to the division septum and that its colocalization requires the presence of the late division protein FtsN. Although Blr is not essential, previous studies have shown that the inactivation of the blr gene increased the sensitivity of bacteria to β-lactam antibiotics or their resistance to cell envelope stress. Here, we found that Blr, when overproduced, restores the viability of E. coli ftsQ1(Ts) cells, carrying a thermosensitive allele of the ftsQ gene, during growth under low-osmotic-strength conditions (e.g., in synthetic media or in Luria-Bertani broth without NaCl). In contrast, the inactivation of blr increases the osmosensitivity of ftsQ1(Ts) cells, and blr ftsQ1 double mutants exhibit filamentous growth in LB broth even at a moderate salt concentration (0.5% NaCl) compared to parental ftsQ1(Ts) cells. Altogether, our results suggest that the small membrane polypeptide Blr is a novel component of the E. coli cell division apparatus involved in the stabilization of the divisome under certain stress conditions.
Optoelectronic switching of nanowire-based hybrid organic/oxide/semiconductor field-effect transistors (2014)

A novel photosensitive hybrid field-effect transistor (FET) which consists of a multiple-shell of organic porphyrin film/oxide/silicon nanowires is presented. Due to the oxide shell around the nanowires, photoswitching of the current in the hybrid nanodevices is guided by the electric field effect, induced by charge redistribution within the organic film. This principle is an alternative to a photoinduced electron injection, valid for devices relying on direct junctions between organic molecules and metals or semiconductors. The switching dynamics of the hybrid nanodevices upon violet light illumination is investigated and a strong dependence on the thickness of the porphyrin film wrapping the nanowires is found. Furthermore, the thickness of the organic films is found to be a crucial parameter also for the switching efficiency of the nanowire FET, represented by the ratio of currents under light illumination (ON) and in dark conditions (OFF). We suggest a simple model of porphyrin film charging to explain the optoelectronic behavior of nanowire FETs mediated by organic film/oxide/semiconductor junctions.
A proteomic study of the HUPO Plasma Proteome Project's pilot samples using an accurate mass and time tag strategy (2005)

Characterization of the human blood plasma proteome is critical to the discovery of routinely useful clinical biomarkers. We used an accurate mass and time (AMT) tag strategy with high-resolution mass accuracy cLC-FT-ICR MS to perform a global proteomic analysis of pilot study samples as part of the HUPO Plasma Proteome Project. HUPO reference serum and citrated plasma samples from African Americans, Asian Americans, and Caucasian Americans were analyzed, in addition to a Pacific Northwest National Laboratory reference serum and plasma. The AMT tag strategy allowed us to leverage two previously published "shotgun" proteomics experiments to perform global analyses on these samples in triplicate in less than 4 days total analysis time. A total of 722 (22% with multiple peptide identifications) International Protein Index redundant proteins, or 377 protein families by ProteinProphet, were identified over the six individual HUPO serum and plasma samples. The samples yielded a similar number of identified redundant proteins in the plasma samples (average 446 +/- 23) as found in the serum samples (average 440 +/- 20). These proteins were identified by an average of 956 +/- 35 unique peptides in plasma and 930 +/- 11 unique peptides in serum. In addition to this high-throughput analysis, the AMT tag approach was used with a Z-score normalization to compare relative protein abundances. This analysis highlighted both known differences in serum and citrated plasma such as fibrinogens, and reproducible differences in peptide abundances from proteins such as soluble activin receptor-like kinase 7b and glycoprotein m6b. The AMT tag strategy not only improved our sample throughput but also provided a basis for estimated quantitation.
Economic comparison of herbicides for weed control in sugarbeets (1972)

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Biomimetic Fenton‐Catalyzed Lignin Depolymerization to High‐Value Aromatics and Dicarboxylic Acids (2015)

By mimicking natural lignin degradation systems, the Fenton catalyst (Fe(3+), H2O2) can effectively facilitate lignin depolymerization in supercritical ethanol (7 MPa, 250 °C) to give organic oils that consist of mono- and oligomeric aromatics, phenols, dicarboxylic acids, and their derivatives in yields up to (66.0±8.5) %. The thermal properties, functional groups, and surface chemistry of lignin before and after Fenton treatment were examined by thermogravimetric analysis, pyrolysis-gas chromatography-mass spectrometry, (31)P NMR spectroscopy, and X-ray photoelectron spectroscopy. The results suggest that the Fenton catalyst facilitates lignin depolymerization through cleavage of β-ether bonds between lignin residues. The formation of a lignin-iron chelating complex effectively depresses lignin recondensation; thus minimizing charcoal formation and enhancing the yield of liquid products.
Inversionsrandschichten auf p-Silicium (1957)

Auf der defektleitenden Seite eines Siliciumstäbchens, das in der Mitte einen pn-Übergang enthält, bildet sich unter dem Einfluß von Wasserdampf eine elektronenleitende Inversionsrandschicht aus, welche in trockenem Sauerstoff wieder verschwindet. Durch Sperrstrom- und Kapazitätsmessungen wird dieser „Channel“ nachgewiesen und durch Abtasten der Kristalloberfläche mit einer Lichtsonde seine wirksame Länge bestimmt. Die Leitfähigkeit der Randschicht kann durch Kombination der verschiedenen Messungen ermittelt werden. Sie liegt in der Größenordnung von 10 -5 bis 10 -6 Ohm -1 . Aus dem zeitlichen Verlauf des Sperrstroms nach einer Spannungsänderung ergibt sich, daß zwei Arten von Oberflächenzuständen existieren, von denen sich die eine in sehr kurzer Zeit mit dem Leitungsband ins Gleichgewicht setzt, während für die andere Relaxationszeiten von 10 bis 50 Minuten beobachtet werden. Ein Vergleich mit entsprechenden Messungen an Germanium zeigt, daß die Dichte der „schnellen“ Zustände bei Silicium wesentlich größer ist als bei Germanium.
Methionine Adenosyltransferase and Ethionine Resistance in <i>Saccharomyces cerevisiae</i> (1972)

The methionine adenosyltransferase is repressed in Saccharomyces cerevisiae during growth in the presence of excess methionine. The relationship of this repression to the level of intracellular S-adenosylmethionine is discussed. In conjunction with these studies, an ethionine-resistant mutant has been investigated which has a low level of methionine adenosyltransferase under all conditions tested. The mechanism of ethionine resistance in the latter strain apparently depends on its inability to form large quantities of intracellular S-adenosylethionine. With respect to the methionine adenosyltransferase, there is no apparent interaction between ethionine-resistant and ethionine-sensitive alleles when both are present in the heterozygous diploid.
Fabricating tunable semiconductor devices with an atomic force microscope (1999)

We fabricated quantum wires of different geometries in Ga[Al]As heterostructures by local oxidation of the semiconductor surface with an atomic force microscope. By magnetotransport measurements at low temperatures on these wires the electronic width is determined and compared to the geometrical width. An extremely small lateral depletion length of the order of 15 nm and a high specularity of the scattering at the confining walls is found. Furthermore, we demonstrate experimentally that these quantum wires can be tuned by a combination of in-plane gates and top gates.
Intravenous Administration of Modified Gamma Globulin (1967)

Persons injected intravenously with human γ-globulin may develop symptoms which include anxiety, flushing of the face, a constricting feeling in the chest, muscle pain in the trunk or thighs, nausea and vomiting, fever, and rarely collapse.<sup>1-3</sup>In one study seven of 54 subjects receiving 110 ml of 1.5% γ-globulin solution intravenously experienced a reaction.<sup>1</sup>However, readministration, if within 72 hours, was well tolerated even by those who previously had reacted unfavorably. Individual susceptibility as well as rate of infusion, total amount given and perhaps the specific γ-globulin preparation may be determinants in the frequency and severity of symptoms. Peculiarly, the incidence of systemic reactions was extremely high in those with antibody deficiency syndromes such as primary agammaglobulinemia.<sup>1,4</sup>By contrast, pepsin treated preparations of γ-globulin elicited few or no symptoms when given to people with a variety of diseases including agammaglobulinemia.<sup>5-7</sup> The present report describes symptoms and laboratory findings observed during
Mutual authenticating protocol with key distribution in client/server environment (1996)

The explosive growth of networked and internetworked computer systems during the past decade has brought about a need for increased protection mechanisms. This paper discusses three authentication protocols that incorporate the use of methods that present effective user authentication. The first two protocols have been previously discussed in the literature; the third protocol draws from the first two and others to produce an authentication scheme that provides both mutual authentication and secure key distribution which is easy to use, is compatible with present operating systems, is transparent across systems, and provides password file protection.
Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis (2018)

snRNA-seq achieves comparable gene detection to scRNA-seq in adult kidney, and it also has substantial advantages, including reduced dissociation bias, compatibility with frozen samples, elimination of dissociation-induced transcriptional stress responses, and successful performance on inflamed fibrotic kidney.
On the Stability of Poly‐Ethylenedioxythiopene as Coating Material for Active Neural Implants (2011)

This article deals with the stability of poly-ethylenedioxythiopene (PEDOT) coatings under high loads of current pulses. Test parameters were chosen to match many peripheral nervous system applications in regard of charge injection, pulse width, and repetition frequency. PEDOT coatings were characterized with electrochemical impedance spectroscopes and pulse tests. After 60-100 million pulses, impedance increased and a more capacitive behavior was observed. A mean-time-to-failure of 127 million pulses could be calculated, suggesting a stable coating for at least this time frame with superior properties in regard of conventional platinum electrodes.
Synthesis and evaluation as platelet aggregation inhibitors of 6-phenyl-2,4-substituted-3(2H)-pyridazinones and their rigid analogues benzo[h]cinnolin-3,5-diones. (1996)

A series of 5-acyl-6-phenyl-2,4-substituted-3(2H)-pyridazinones and analogous benzo[h]cinnolin-3,5-diones with reduced flexibility has been prepared and evaluated as human platelet aggregation inhibitors. The 4-methylsulfoxide 13b was the most potent compound of the series (IC50 = 1.2 microM). SAR studies have shown the primary importance of an electronegative substituent at position 4 and an acetyl group at position 5 of the pyridazine system for potent platelet aggregation inhibitory activity. Biological tests performed on a group of representative compounds showed these products have not effects on prostaglandins, thromboxanes and nitric oxide biosynthetic pathways. Some of synthesized compounds produced a moderate increase of cAMP level in platets which does not depend on the adenylate-cyclase stimulation. Tests performed on human platelet PDE III have shown that these compounds are not inhibitors of this enzyme.
Isotopic chemical vapor deposition of fused silica and high-silica-content glasses for the production of low-loss optical waveguides (1977)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Daisuke Kato and Robert G. Lamont, "Isotopic chemical vapor deposition of fused silica and high-silica-content glasses for the production of low-loss optical waveguides," Appl. Opt. 16, 1453-1454 (1977) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Allocation and matching in kidney exchange programs (2013)

Living donor kidney transplantation is the preferred treatment for patients suffering from end-stage renal disease. To alleviate the shortage of kidney donors, many advances have been made to improve the utilization of living donors deemed incompatible with their intended recipient. The most prominent of these advances is kidney paired donation (KPD), which matches incompatible patient-donor pairs to facilitate a kidney exchange. This review discusses the various approaches to matching and allocation in KPD. In particular, it focuses on the underlying principles of matching and allocation approaches, the combination of KPD with other strategies such as ABO incompatible transplantation, the organization of KPD, and important future challenges. As the transplant community strives to balance quantity and equity of transplants to achieve the best possible outcomes, determining the right long-term allocation strategy becomes increasingly important. In this light, challenges include making full use of the various modalities that are now available through integrated and optimized matching software, encouragement of transplant centers to fully participate, improving transplant rates by focusing on the expected long-run number of transplants, and selecting uniform allocation criteria to facilitate international pools.
Highly crystalline cobalt nanowires with high coercivity prepared by soft chemistry (2009)

Abstract Cobalt nanorods and wires were prepared by reduction of a cobalt salt in a liquid polyol. These particles crystallize with the hcp structure and the growth axis is parallel to the crystallographic c ‐axis. The kinetic control of the growth allows to vary the mean diameter of the rods and their aspect ratio. Dumbbell like shape particles consisting of a central rod with two conical tips were also obtained. Magnetization curves of oriented wires present very high coercivity (up to 9 kOe) resulting from both a high shape anisotropy and the high magnetocrystalline anisotropy of the hcp cobalt. Micromagnetic simulations showed that the magnetization reversal is shape dependent. The conical tips of the dumbbell particles strongly contribute to the coercivity decrease and must be precluded for permanent magnet applications. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Q switching by saturable absorption in microdroplets: elastic scattering and laser emission (1997)

Laser-induced modification of cavity Q's has been achieved in a microdroplet containing a saturable absorber. The elastic-scattering spectra from such droplets for higher incident intensities show that cavity Q's are increased when the absorption is bleached. The lasing spectra from a droplet containing a saturable absorber and laser dye are modified when an intense bleaching field is injected into the droplet cavity after the pump field has initiated the lasing.
Development of a Miniaturized Multisensory Positioning Device for Laser Dicing Technology (2011)

In this study we propose a multisensory laser tracker system for measuring and tracking the TCP (Tool Center Point) of e.g. high precision motion systems. An experimental platform composed of four tracker modules is developed in order to track the TCP of a linear positioning system based upon the length measurement (multi-lateration). Concepts and first devices for miniaturization of the tracker system are presented.
Indomethacin Treatment in Osteoarthritis of the Hip Joint:<i>Does the Treatment Interfere with the Natural Course of the Disease?</i> (1979)

The course of osteoarthritis in 294 hips of 186 patients was evaluated by examining their radiographs. The development of the disease in patients treated with indomethacin was compared with that in a control material. In the indomethacin group the disease progressed more frequently and in one parameter the progress was more severe. The results support previous reports indicating that indomethacin might have a deleterious effect on osteoarthritic hip joints. Some possible explanations for this adverse effect of indomethacin treatment are discussed.
The Clinical Picture of Olanzapine Poisoning with Special Reference to Fluctuating Mental Status (2004)

Although olanzapine is tolerated relatively well in acute overdose, unpredictable and transient fluctuations between central nervous system depression and agitation, frequently associated with miosis, appear to be characteristic findings in moderate to high olanzapine overdoses. They are transient in nature and require careful clinical monitoring but rarely require specific therapeutic interventions.
Haloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder (1994)

The results of this study suggest that OCD patients with a comorbid chronic tic disorder constitute a clinically meaningful subtype of OCD that might require conjoint serotonin-uptake inhibitor/neuroleptic therapy for effective symptom reduction.
RELIEF VALVES AND VENTS: HOW EXIT CONDITIONS AFFECT HAZARD ZONES (1990)

Pressure relief valves and vents in the petrochemical industry are often the last line of defense in averting a major accident. Recent design standards (API 520/521) have been developed which have reduced the recommended exit velocities for hydrocarbons from pressurized storage. There are computer models available which predict the release and dispersion of high velocity gas jets. In some instances, these models have been modified to account for the formation and dispersion of aerosol clouds. This paper will compare the API recommended practices with actual test data and current model predictions. INTRODUCTION Within the hydrocarbon and chemical processing industries, the use of pressure relief devices to protect process equipment and storage tanks from excessive internal pressure is commonplace, and is often required by government or industry codes. In many cases, discharges from pressure relief devices flow through a closed piping system to an elevated vent or flare. One primary function of an elevated flare or vent is to safely dispose of flammable and/or toxic gases released by the pressure relief devices, either by burning the gas to create less hazardous products of combustion, or by releasing it at an elevation that is sufficient to ensure that hazardous concentrations of the gas will not return to grade level. This type of system generally works well and is often the preferred method for disposing of hazardous gases released from pressure relief devices. However, such systems are not, and cannot be, used universally. There are many situations where it is not practical to connect pressure relief devices to a vent or flare header. For example, pressure safety valves (PSVs) on storage tanks for refrigerated liquefied gases relieve at low pressures, typically 2.0 psig or less. To safely dispose of this low pressure gas through an elevated flare or vent would require a very large diameter header system, otherwise the pressure drop in the header would create excessive backpressure on the relief valves. A similar argument applies to vent valves on API cone roof tanks.
Vitamin B<sub>12</sub>and folate in relation to the development of Alzheimer’s disease (2001)

<b><i>Objective: </i></b> To explore the associations of low serum levels of vitamin B<sub>12</sub> and folate with AD occurrence. <b><i>Methods:</i></b> A population-based longitudinal study in Sweden, the Kungsholmen Project. A random sample of 370 nondemented persons, aged 75 years and older and not treated with B<sub>12</sub> and folate, was followed for 3 years to detect incident AD cases. Two cut-off points were used to define low levels of vitamin B<sub>12</sub> (≤150 and ≤250 pmol/L) and folate (≤10 and ≤12 nmol/L), and all analyses were performed using both definitions. AD and other types of dementia were diagnosed by specialists according to DSM-III-R criteria. <b><i>Results:</i></b> When using B<sub>12</sub> ≤150pmol/L and folate ≤10 nmol/L to define low levels, compared with people with normal levels of both vitamins, subjects with low levels of B<sub>12</sub><i>or</i> folate had twice higher risks of developing AD (relative risk [RR] = 2.1, 95% CI = 1.2 to 3.5). These associations were even stronger in subjects with good baseline cognition (RR = 3.1, 95% CI = 1.1 to 8.4). Similar relative risks of AD were found in subjects with low levels of B<sub>12</sub><i>or</i> folate and among those with both vitamins at low levels. A comparable pattern was detected when low vitamin levels were defined as B<sub>12</sub> ≤250 pmol/L and folate ≤12 nmol/L. <b><i>Conclusions:</i></b> This study suggests that vitamin B<sub>12</sub> and folate may be involved in the development of AD. A clear association was detected only when both vitamins were taken into account, especially among the cognitively intact subjects. No interaction was found between the two vitamins. Monitoring serum B<sub>12</sub> and folate concentration in the elderly may be relevant for prevention of AD.
<i>In Vitro</i>Antiviral Characteristics of HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068 (2012)

BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120. In order to better understand the anti-HIV-1 spectrum of BMS-626529 against HIV-1, in vitro activities against a wide variety of laboratory strains and clinical isolates were determined. BMS-626529 had half-maximal effective concentration (EC(50)) values of <10 nM against the vast majority of viral isolates; however, susceptibility varied by >6 log(10), with half-maximal effective concentration values in the low pM range against the most susceptible viruses. The in vitro antiviral activity of BMS-626529 was generally not associated with either tropism or subtype, with few exceptions. Measurement of the binding affinity of BMS-626529 for purified gp120 suggests that a contributory factor to its inhibitory potency may be a relatively long dissociative half-life. Finally, in two-drug combination studies, BMS-626529 demonstrated additive or synergistic interactions with antiretroviral drugs of different mechanistic classes. These results suggest that BMS-626529 should be active against the majority of HIV-1 viruses and support the continued clinical development of the compound.