gebhart/patrepeval huggingface dataset:
Investigations in the Transition Metal Catalyzed Aziridination of Olefins, Amination, and Other Insertion Reactions with Bromamine-T as the Source of Nitrene (2000)

Investigations into the transition metal catalyzed aziridination of olefins with Bromamine-T as a new source of nitrene is presented in this account. Comparison of Chloramine-T and Bromamine-T in this reaction indicates that the latter is superior as the source of nitrene. Systematic study with several transition metal based catalysts suggests that Cu-halides are the best catalysts. A first report of aziridination under microwave and ultrasound irradiation conditions is also presented. Copper-catalyzed aziridination of methyl cinnamate with Bromamine-T did not proceed at ambient temperature but was effected smoothly under ultrasound irradiation to furnish trans-aziridine selectively, while under microwave irradiation, a mixture of cis and trans isomers, was obtained. It has been demonstrated that aziridination of olefins proceeds smoothly with inexpensive bleaching powder. Preliminary results of Rh-catalyzed benzylic insertion reactions with Bromamine-T are included in this account.
Complementation of the rev gene mutation among human and simian lentiviruses (1990)

The functional exchangeability of the rev gene was assessed in transient transfection experiments by using in vitro-constructed rev and gag mutants of the following three primate lentiviruses: human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus from the African green monkey (SIV AGM). Cotransfection into SW480 cells of the rev and gag mutants derived from the DNA of each infectious virus resulted in the generation of progeny particles as determined by reverse transcriptase assay. rev gene mutants of HIV-2 and SIV AGM were also complemented by all gag mutants derived from the three viruses. In contrast, no evidence of complementation was obtained following cotransfection of the HIV-1 rev mutant and the gag mutant of HIV-2 or SIV AGM.
Gastrointestinal disease : an endoscopic approach (1997)

Designing clinical research in gastrointestinal endoscopy the prevention of infection following gastrointestinal endoscopy complications of gastroduodenal disease credentialing and QA in the Endoscopy Unit. (part contents)
Multisensor configurations for early sniper detection (2011)

This contribution reports some of the fusion results from the EDA SNIPOD project, where different multisensor configurations for sniper detection and localization have been studied. A project aim has been to cover the whole time line from sniper transport and establishment to shot. To do so, different optical sensors with and without laser illumination have been tested, as well as acoustic arrays and solid state projectile radar. A sensor fusion node collects detections and background statistics from all sensors and employs hypothesis testing and multisensor estimation programs to produce unified and reliable sniper alarms and accurate sniper localizations. Operator interfaces that connect to the fusion node should be able to support both sniper countermeasures and the guidance of personnel to safety. Although the integrated platform has not been actually built, sensors have been evaluated at common field trials with military ammunitions in the caliber range 5.56 to 12.7 mm, and at sniper distances up to 900 m. It is concluded that integrating complementary sensors for pre- and postshot sniper detection in a common system with automatic detection and fusion will give superior performance, compared to stand alone sensors. A practical system is most likely designed with a cost effective subset of available complementary sensors.
Mathematical Model Of Using Simulated Lung Ching Tea Waste And Eggshell In Wool Dyeing Process (1999)

Attempt has been made to extract the dyes from waste materials such as simulated tea waste and applied it in wool dyeing. In this paper, the central composition experimental design of multivariate Response Surface Method was used to formulate mathematical models aiming to predict (1) the optimum dyeing conditions of simulated waste Lung Ching tea dye for wool fabric, and (2) the optimum extraction conditions of a natural mordant originated from common waste eggshell. The pre-mordanting process using eggshell as a mordant to lieu of traditional heavy metal mordants was applied to wool fabric followed by dyeing with simulated waste Lung Ching tea extract under the optimum dyeing conditions. The improvement of pre-mordanting process on dye uptake and colour fastness properties has been evaluated.
A high-current density and long lifetime ECR source for oxygen implanters (1990)

A high-current ECR source has been developed for oxygen implanters for use in fabricating separation by implanted oxygen (SIMOX) substrates. The new source has the following features: (1) high-current density (150 mA/cm2) and large extracted current (more than 200 mA), (2) stable and long lifetime operation (more than 200 h), (3) high O+ ratio (more than 80%), and (4) low-divergence beam. The improved performance is obtained by incorporating the following: (1) Localized high-density plasma generation at the center of the plasma chamber. (2) A newly developed multilayer window to satisfy two requirements: efficient coupling of the microwave with high-density plasma and high resistance to high-speed backstream electrons. (3) Optimized combination of plasma chamber length and axial magnetic field distribution. (4) Sophisticated compact magnetic circuit that yields the optimum magnetic field for obtaining high-density plasma. An industrial-version ECR source was developed for production use on EATON NV-200 implanters. The source was installed on an NV-200 and used to implant oxygen ions to Si wafers. Good performance compared to a duopigatron source was obtained in terms of beam transport efficiency and reliability of source operation.
The greenhouse effect: radiant transmittance of glass (1987)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. H. Taylor, "The greenhouse effect: radiant transmittance of glass," Optics News 13(9), 35-35 (1987) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Antifungal Protein PAF Severely Affects the Integrity of the Plasma Membrane of<i>Aspergillus nidulans</i>and Induces an Apoptosis-Like Phenotype (2005)

The small, basic, and cysteine-rich antifungal protein PAF is abundantly secreted into the supernatant by the beta-lactam producer Penicillium chrysogenum. PAF inhibits the growth of various important plant and zoopathogenic filamentous fungi. Previous studies revealed the active internalization of the antifungal protein and the induction of multifactorial detrimental effects, which finally resulted in morphological changes and growth inhibition in target fungi. In the present study, we offer detailed insights into the mechanism of action of PAF and give evidence for the induction of a programmed cell death-like phenotype. We proved the hyperpolarization of the plasma membrane in PAF-treated Aspergillus nidulans hyphae by using the aminonaphtylethenylpyridinium dye di-8-ANEPPS. The exposure of phosphatidylserine on the surface of A. nidulans protoplasts by Annexin V staining and the detection of DNA strand breaks by TUNEL (terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling) gave evidence for a PAF-induced apoptotic-like mechanism in A. nidulans. The localization of reactive oxygen species (ROS) by dichlorodihydrofluorescein diacetate and the abnormal cellular ultrastructure analyzed by transmission electron microscopy suggested that ROS-elicited membrane damage and the disintegration of mitochondria played a major role in the cytotoxicity of PAF. Finally, the reduced PAF sensitivity of A. nidulans strain FGSC1053, which carries a dominant-interfering mutation in fadA, supported our assumption that G-protein signaling was involved in PAF-mediated toxicity.
Application-specific microelectronics for mechatronic systems (1992)

A methodology for the design of microelectronic subsystems in a mechatronic environment is presented, and its application to various problems is described. Several strategies from hardware-in-the-loop simulation over rapid prototyping of ASIC-based systems with field programmable gate arrays to the design of application-specific integrated processors are offered. The efficiency of the design system is demonstrated for three mechatronic applications: a self-controlled clutch, ignition control of a combustion engine, and a turbine compressor unit state estimator. >
Microwave decomposition of toxic vapor simulants (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicrowave decomposition of toxic vapor simulantsLionel J. Bailin, Merle E. Sibert, Leonard A. Jonas, and Alexis T. BellCite this: Environ. Sci. Technol. 1975, 9, 3, 254–258Publication Date (Print):March 1, 1975Publication History Published online1 May 2002Published inissue 1 March 1975https://doi.org/10.1021/es60101a005RIGHTS & PERMISSIONSArticle Views99Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (624 KB) Get e-Alertsclose Get e-Alerts
Making DidFail Succeed: Enhancing the CERT Static Taint Analyzer for Android App Sets (2015)

This report describes recent significant enhancements to DidFail (Droid Intent Data Flow Analysis for Information Leakage), the CERT static taint analyzer for sets of Android apps. In addition to improving the analyzer itself, the enhancements include a new testing framework, new test apps, and test results. A framework for testing the DidFail analyzer, including a setup for cloud-based testing was developed and instrumented to measure performance. Cloud-based testing enables the parallel use of powerful, commercially available virtual machines to speed up testing. DidFail was also modified to use the most current version of FlowDroid and Soot, increasing its success rate from 18% to 68% on our test set of real-world apps. Analytical features were added for more types of components and shared static fields and new apps developed to test these features. The improved DidFail analyzer and the cloud-based testing framework were used to test the new apps and additional apps from the Google Play store.
The humoral immune response to macrocyclic chelating agent DOTA depends on the carrier molecule. (2001)

The chelating agent 1,4,7,10-tetraazacyclododecane-N,N', N",N"'-tetraacetic acid (DOTA) is used to label monoclonal antibodies (mAbs) and peptides with (90)Y. DOTA allows the generation of clinically useful stable metallic radioconjugates for the treatment of a variety of tumors, but its immunogenicity has remained controversial. In this study, we evaluated the immune response to DOTA in a preclinical mouse model and in patients entered in a clinical trial.Sera were obtained from BALB/c mice injected intraperitoneally or subcutaneously with different doses and formulations of syngeneic and xenogeneic mAbs or peptide (murine mAb Mov19 [mM19]; its chimeric version; murine V/human C ChiMov19 [cM19]; or Tyr(3)-octreotide)-DOTA conjugates. Sera from patients with neuroendocrine tumors, enrolled in a protocol for somatostatin receptor-mediated radionuclide therapy with (90)Y-DOTA-D-Phe(1)-Tyr(3)-octreotide (DOTATOC), were also collected before and after each treatment. Levels and specificity of antibody response to relevant (Mov19, ChiMov19, or Tyr(3)-octreotide) and nonrelevant (human serum albumin) DOTA targets were tested by enzyme-linked immunosorbent assay and competition assays. An anti-DOTA mAb (IgG1) derived from a ChiMov19-DOTA immunized mouse was used, in a competitive radioimmunoassay, to determine the efficiency of DOTA presentation on the different carriers.Depending on the immunogenicity and dosage of the mAb, a specific anti-DOTA response was revealed in the preclinical system. However, DOTA-peptide conjugate induced no immune-detectable response against either chelator or carrier. DOTA was poorly presented on small peptides, as determined using the anti-DOTA mAb.A humoral response against DOTA is possible, but only as a consequence of the response elicited against the carrier. Octreotide was not immunogenic. Thus, (90)Y-DOTATOC can be considered a safe and useful tool for receptor-mediated radionuclide therapy of somatostatin receptor-overexpressing tumors.
Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update (2018)

Two recommendations addressed via correspondence in 2015 are included. First, immunohistochemistry (IHC) 2+ is defined as invasive breast cancer with weak to moderate complete membrane staining observed in >10% of tumor cells. Second, if the initial HER2 test result in a core needle biopsy specimen of a primary breast cancer is negative, a new HER2 test may (not "must") be ordered on the excision specimen based on specific clinical criteria. The HER2 testing algorithm for breast cancer is updated to address the recommended workup for less common clinical scenarios (approximately 5% of cases) observed when using a dual-probe ISH assay. These scenarios are described as ISH group 2 ( HER2/chromosome enumeration probe 17 [CEP17] ratio ≥2.0; average HER2 copy number <4.0 signals per cell), ISH group 3 ( HER2/CEP17 ratio <2.0; average HER2 copy number ≥6.0 signals per cell), and ISH group 4 ( HER2/CEP17 ratio <2.0; average HER2 copy number ≥4.0 and <6.0 signals per cell). The diagnostic approach includes more rigorous interpretation criteria for ISH and requires concomitant IHC review for dual-probe ISH groups 2 to 4 to arrive at the most accurate HER2 status designation (positive or negative) based on combined interpretation of the ISH and IHC assays. The Expert Panel recommends that laboratories using single-probe ISH assays include concomitant IHC review as part of the interpretation of all single-probe ISH assay results.
Laser Diode Cooling For High Average Power Applications (1989)

Many applications for semiconductor lasers that require high average power are limited by the inability to remove the waste heat generated by the diode lasers. In order to reduce the cost and complexity of these applications a heat sink package has been developed which is based on water cooled silicon microstructures. Thermal resistivities of less than 0.025°C/01/cm2) have been measured which should be adequate for up to CW operation of diode laser arrays. This concept can easily be scaled to large areas and is ideal for high average power solid state laser pumping. Several packages which illustrate the essential features of this design have been fabricated and tested. The theory of operation will be briefly covered, and several conceptual designs will be described. Also the fabrication and assembly procedures and measured levels of performance will be discussed.
Computerized Automated Reminder Diabetes System (CARDS): E-Mail and SMS Cell Phone Text Messaging Reminders to Support Diabetes Management (2009)

Cell phone text messaging to promote BG monitoring is a viable and acceptable option in adolescents and young adults with diabetes. However, maintaining interest levels for prolonged intervals remains a challenge.
Caspases Induce Cytochrome c Release from Mitochondria by Activating Cytosolic Factors (1999)

We investigated the ability of caspases (cysteine proteases with aspartic acid specificity) to induce cytochrome c release from mitochondria. When Jurkat cells were induced to undergo apoptosis by Fas receptor ligation, cytochrome c was released from mitochondria, an event that was prevented by the caspase inhibitor, zVAD-fmk (zVal-Ala-Asp-CH2F). Purified caspase-8 triggered rapid cytochrome c release from isolated mitochondria in vitro. The effect was indirect, as the presence of cytosol was required, suggesting that caspase-8 cleaves and activates a cytosolic substrate, which in turn is able to induce cytochrome c release from mitochondria. The cytochrome c releasing activity was not blocked by caspase inhibition, but was antagonized by Bcl-2 or Bcl-xL. Caspase-8 and caspase-3 cleaved Bid, a proapoptotic Bcl-2 family member, which gains cytochrome c releasing activity in response to caspase cleavage. However, caspase-6 and caspase-7 did not cleave Bid, although they initiated cytochrome c release from mitochondria in the presence of cytosol. Thus, effector caspases may cleave and activate another cytosolic substrate (other than Bid), which then promotes cytochrome c release from mitochondria. Mitochondria significantly amplified the caspase-8 initiated DEVD-specific cleavage activity. Our data suggest that cytochrome c release, initiated by the action of caspases on a cytosolic substrates, may act to amplify a caspase cascade during apoptosis.
Efficient cloning of PCR generated DNA containing terminal restriction endonuclease recognition sites (1990)

Journal Article Efficient cloning of PCR generated DNA containing terminal restriction endonuclease recognition sites Get access V. Jung, V. Jung Department of Molecular Genetics and Microbiology, UMDNJ-Robert Wood Johnson Medical School675 Hoes Lane, Piscataway, NJ 08854-5635, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar S.B. Pestka, S.B. Pestka Department of Molecular Genetics and Microbiology, UMDNJ-Robert Wood Johnson Medical School675 Hoes Lane, Piscataway, NJ 08854-5635, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Pestka S. Pestka * Department of Molecular Genetics and Microbiology, UMDNJ-Robert Wood Johnson Medical School675 Hoes Lane, Piscataway, NJ 08854-5635, USA *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 20, 25 October 1990, Page 6156, https://doi.org/10.1093/nar/18.20.6156 Published: 25 October 1990 Article history Received: 16 August 1990 Published: 25 October 1990
The Vanderbilt PICC Service: Program, Procedural, and Patient Outcomes Successes (2005)

Abstract Since its inception in early 2000, Vanderbilt University's Peripherally Inserted Central Catheter (PICC) Service has experienced a high level of success as measured by high proficiency rates and increasing patient procedures each year, low complication rates during and after PICC placements, and an increasing scope of influence within the Vanderbilt University Medical Center and Children's Hospital, the surrounding community, and in the Southeastern United States. Primary drivers of the PICC Service's continuing success include consistent applications of technique and technology, a data-driven approach to assessing the program's progress, and appropriately managing customers' expectations and needs. Over the past five years, data were collected on more than 12,500 PICC placements performed in this specialized nursing program. Retrospective analyses of the data demonstrate an increasing rate of successful placements (from 87.2% to 92.4%) since the program's inception in 2000 to late 2004. Furthermore, the choice of PICC technology has had a significant impact on the odds for occlusion or infection. The Vanderbilt PICC Service provides a model by which other programs can be established, maintained, and expanded into advanced practice.
Growing a Tree in the Forest: Constructing Folksonomies by Integrating Structured Metadata (2010)

Many social Web sites allow users to annotate the content with descriptive metadata, such as tags, and more recently to organize content hierarchically. These types of structured metadata provide valuable evidence for learning how a community organizes knowledge. For instance, we can aggregate many personal hierarchies into a common taxonomy, also known as a folksonomy, that will aid users in visualizing and browsing social content, and also to help them in organizing their own content. However, learning from social metadata presents several challenges, since it is sparse, shallow, ambiguous, noisy, and inconsistent. We describe an approach to folksonomy learning based on relational clustering, which exploits structured metadata contained in personal hierarchies. Our approach clusters similar hierarchies using their structure and tag statistics, then incrementally weaves them into a deeper, bushier tree. We study folksonomy learning using social metadata extracted from the photo-sharing site Flickr, and demonstrate that the proposed approach addresses the challenges. Moreover, comparing to previous work, the approach produces larger, more accurate folksonomies, and in addition, scales better.
Relationship of Mediterranean Diet and Caloric Intake to Phenoconversion in Huntington Disease (2013)

MeDi was not associated with phenoconversion; however, higher consumption of dairy products had a 2-fold increased risk and may be a surrogate for lower urate levels (associated with faster progression in manifest HD). Studies of diet and energy expenditure in premanifest HD may provide data for interventions to modify specific components of diet that may delay the onset of HD.
Inhibition of ristocetin-induced platelet agglutination by vancomycin (1977)

Abstract Ristocetin and vancomycin are structurally similar glycopeptide antibiotics. Both vancomycin and ristocetin in high concentrations (3.0 mg/ml) cause the precipitation of fibrinogen, plasminogen, and IgG from platelet-poor plasma (PPP). In contrast to ristocetin, vanomycin (0.5–1.5 mg/ml) does not agglutinate platelets in normal platelet-rich plasma (PRP) or formalin-treated platelets in the presence of normal PPP. Preincubation of vancomycin (0.5–1.25 mg/ml) with normal PRP, von Willebrand platelets in normal PPP, or formalinized platelets results in inhibition of platelet agglutination induced by ristocetin (0.7–1.25 mg/ml) or ristocetin and normal PPP. This inhibition can be overcome by increasing the final concentration of ristocetin in the platelet suspension. Preincubation of formalin-treated platelets with the major fraction obtained by carboxymethyl-Sephadex C-50 chromatography of commercial vancomycin also results in inhibition of agglutination induced by ristocetin and normal PPP. Incubation with vancomycin (1.25 mg/ml) does not interfere with von Willebrand factor (vWF) or factor VIII coagulant activities in normal PPP or in Sepharose 4B void volume fractions of PPP. These results indicate that vancomycin interacts with normal, von Willebrand, and formalin-treated platelets and inhibits the binding of ristocetin (or ristocetin-vWF complexes).