gebhart/patrepeval huggingface dataset:
Association Between the Natriuretic Action of Angiotensin-(1-7) and Selective Stimulation of Renal Prostaglandin I<sub>2</sub>Release (1995)

We previously reported that angiotensin-(1-7) [Ang-(1-7)], a heptapeptide derived from the metabolism of either Ang I or Ang II, was biologically active in the rat isolated kidney, producing a marked diuresis and natriuresis that could be dissociated from the modest increase in glomerular filtration rate. The natriuretic response was accompanied by an increase in sodium concentration and concomitant decrease in urinary potassium concentration. Ang-(1-7) has also been shown to stimulate arachidonic acid release from isolated proximal tubules and elicit prostaglandin release from a number of tissues. Therefore, in the present study we tested the hypothesis that prostaglandins participate in the renal actions of Ang-(1-7). Rat isolated kidneys were perfused at 37 degrees C with gassed (95% O2/5% CO2) Krebs-Henseleit buffer containing oncotic agents and amino acids for six 10-minute clearance periods at a constant pressure of 90 mm Hg. Ang-(1-7) was infused at a rate that achieved a final concentration of 3 pmol/mL in the presence and absence of 10 mumol/L indomethacin. Prostaglandin E2 (PGE2) and PGI2 released into ureteral and venous effluents were measured by enzyme-linked immunoassay. During Ang-(1-7) infusion there was a selective increase in 6-keto-PGF1 alpha, an index of PGI2, appearing in both urine and perfusate; PGE2 levels were unchanged. Inhibition of stimulated 6-keto-PGF1 alpha release with indomethacin halved the fourfold increase in urine flow and sevenfold increase in sodium excretion rate without altering the increase in urinary sodium concentration produced by Ang-(1-7).(ABSTRACT TRUNCATED AT 250 WORDS)
Advanced Technology Fuel Mass Flowmeter. (1978)

The fuel mass flowmeter system demonstrated in a previous Army program, consisting of an ultrasonic flow velocimeter and a capacitance-type densitometer, was adapted to T-700 gas turbine engine requirements. Mechanical adaptations included the reduction in size and weight of the flow cell to fit the configuration and mounting constraints of a T-700 engine. Electronic developments included repackaging into a portable field-type case, configuration switching and digital delay equalizers, and the substitution of a microprocessor for a previously used calculator chip, resulting in a choice of response times, or integration times, selectable from approximately 50s down to approximately 0.5s.
Behçet’s disease, the Silk Road and HLA‐B51: historical and geographical perspectives (1999)

Behçet's disease (BD), also known as the Silk Road disease, is a blinding inflammatory disorder of young adults found predominantly between the Mediterranean basin and the Orient, and is strongly associated with the major histocompatibility complex (MHC) antigen HLA-B51. In this article we review the history of Behçet's disease since its first description by Hippocrates, the development of the trading routes collectively known as the Silk Road and the effect of population movement on the distribution of HLA-B51. The global distribution of this antigen among healthy control populations bears a striking similarity both to the ancient trading routes and the distribution of Behçet's disease, suggesting a genetic risk that migrated in parallel with population movement between the Mediterranean and Asia. However, certain indigenous Amerindian peoples have a high prevalence of HLA-B51 but no reported cases of BD. Furthermore, a clear genealogical relationship exists between eastern, but not central, Siberian populations with the Amerindians. Since a high level of recombination within the MHC is known to have occurred in these eastern populations before their migration into Beringia, we suggest that disruption of genetic loci in linkage disequilibria with HLA-B51 may be one reason for the absence of disease in these high HLA-B51-bearing populations. However, a contributory influence of environmental factors is not excluded by this data, and the wide variation that exists in relative risk of HLA-B51 even within Europe would support other non-genetic risk factors on the Silk Road which may be absent, or non-contributory to disease, in the Americas.
The design of an object-oriented modular expert system shell (2002)

The Object-Oriented Modular Expert System Shell (OOMESS) is an expert system shell which is designed with the goal of integrating a production system with an object-oriented language. A description is given of the design of OOMESS. The view projected by OOMESS consists of a collection of objects with the capability of communicating with each other. OOMESS provides system support for the modularization of a large rule base into smaller rule groups and provides flexible interactions among rule groups through message passing. The functionality provided by OOMESS includes the accessibility of other rule groups, user-defined objects, and the underlying language from the production rules of a rule group.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Linker scan analysis of the early regulatory region of human papovavirus BK (1988)

BK virus (BKV) is a human papovavirus which latently infects a majority of the world population. Reactivation of this virus is associated with acute hemorrhagic cystitis, and BKV DNA has been found in human tumor tissue. BKV is one of many highly homologous papovaviruses, including simian virus 40 and JC virus, which display distinct host and cell-type specificities, transformation potentials, and pathologies. These differences are thought to be determined, in part, by the noncoding regulatory region of each virus, which contains the origin of replication and regulatory elements for both early and late gene expression. We have used linker scan mutants to map functional elements of a truncated BKV early promoter and enhancer and have studied the stereospecific requirements of these elements. We have also identified protein-binding regions through DNase protection studies. Our results show that a minimum of four elements are necessary for efficient early transcription, at least three of which correspond to DNase-protected domains. These protein-binding elements map to the TATA box and two nuclear factor 1 consensus sequences, one located within the enhancer repeat unit and the other located to the late side of the enhancer. The sequence of the fourth element is similar to the transcription factor Sp1 consensus sequence. Additional DNase-protected sites are centered over AP-1 and Sp1 consensus sequences. Finally, we find that the functional elements of the BKV early promoter and enhancer lack strict stereospecific requirements for efficient transcription.
DESIGN AND SYNTHESIS OF NOVEL FLUOROCYCLOPROPANOID NUCLEOSIDES (2001)

Novel fluorocyclopropanoid nucleosides were designed, synthesized and evaluated their antiviral activities against poliovirus, HSV, HIV, and HBV.
Effect of viscosity and temperature on torsional relaxation of molecular rotors (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of viscosity and temperature on torsional relaxation of molecular rotorsRafik O. Loutfy and Bradley A. ArnoldCite this: J. Phys. Chem. 1982, 86, 21, 4205–4211Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October 1982https://doi.org/10.1021/j100218a023RIGHTS & PERMISSIONSArticle Views1313Altmetric-Citations223LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (838 KB) Get e-Alerts
Monte Carlo study of efficiency roll-off of phosphorescent organic light-emitting diodes: Evidence for dominant role of triplet-polaron quenching (2014)

We present an advanced molecular-scale organic light-emitting diode (OLED) model, integrating both electronic and excitonic processes. Using this model, we can reproduce the measured efficiency roll-off for prototypical phosphorescent OLED stacks based on the green dye tris[2-phenylpyridine]iridium (Ir(ppy)3) and the red dye octaethylporphine platinum (PtOEP) and study the cause of the roll-off as function of the current density. Both the voltage versus current density characteristics and roll-off agree well with experimental data. Surprisingly, the results of the simulations lead us to conclude that, contrary to what is often assumed, not triplet-triplet annihilation but triplet-polaron quenching is the dominant mechanism causing the roll-off under realistic operating conditions. Simulations for devices with an optimized recombination profile, achieved by carefully tuning the dye trap depth, show that it will be possible to fabricate OLEDs with a drastically reduced roll-off. It is envisaged that J90, the current density at which the efficiency is reduced to 90%, can be increased by almost one order of magnitude as compared to the experimental state-of-the-art.
CX-2009, a CD166-directed probody drug conjugate (PDC): Results from the first-in-human study in patients (Pts) with advanced cancer including breast cancer (BC). (2020)

526 Background: CX-2009 is a PROBODY drug conjugate (PDC) directed against CD166 (ALCAM) and conjugated to DM4, a potent microtubule inhibitor (MTI). CD166 is overexpressed in carcinomas but is also ubiquitously expressed in normal epithelium and thus has not been previously considered a viable target for a traditional antibody drug conjugate. PDCs have a peptide mask that blocks normal tissue binding and can be removed by tumor-associated proteases, thereby limiting off-tumor/on-target binding. CX-2009 demonstrated preclinical activity in multiple solid tumor models. Here we report results of the first in human study in patients with advanced cancer. Methods: In this phase I multi-part dose-escalation study, pts with advanced solid tumors received CX-2009 0.25–10 mpk IV every 14 or 21 days (Q2W or Q3W). Tumor types were selected based on expected high CD166 expression and MTI sensitivity. Results: The dose-escalation phase of the trial enrolled 43 pts; 49 additional pts were subsequently enrolled between 4–10 mpk to collect biomarker data and define the recommended phase II dose (RP2D), for a total of 92 pts as of 30 Nov 2019 (39 pts with breast cancer [BC], 22 ovarian [OC], 12 non-small cell lung [NSCLC], 9 head/neck squamous cell [HNSCC], 10 other) with a median of 6 (range 1–19) prior therapies. Median number of CX-2009 doses was 2 (range, 1–15). For Q3W dosing, one dose limiting toxicity (DLT; grade 3 vomiting) was observed at 8 mpk; MTD was not reached up to 10 mpk. The RP2D for Q3W schedule was 7 mpk based on safety, dose-response, and population pharmacokinetic simulations. Q2W dosing continues; DLTs were observed at 6 mpk. Common treatment-related adverse events (TRAEs) at 7 mpk (n=9) were nausea (44%), fatigue, infusion-related reactions (both 33%), vomiting and arthralgias (both 22%). Grade 3 TRAEs occurred in 2 pts (nausea/vomiting; peripheral neuropathy). No pts discontinued at 7 mpk due to TRAEs. Ocular toxicity was dose dependent; mild to moderate reversible keratitis/blurred vision was seen in 3 pts at 7 mpk and mitigated by ocular prophylaxis. Partial responses were seen in 8 pts (2 confirmed, both HR+/HER2- BC) treated between 4–10 mpk, including BC (n=5), OC (n=2), and HNSCC (n=1). SD (≥1 on-study scan) was observed in 21 pts, 5 had SD ≥3 mos. Conclusions: CX-2009 at 7 mpk is the RP2D on Q3W schedule. Phase II expansion has begun in pts with HR+/HER2- BC. The Q2W schedule will continue to enroll pts to define the RP2D. CX-2009 will also be studied in combination with CX-072, a PD-L1 PROBODY therapeutic ( NCT03149549 ) Clinical trial information: NCT03149549 .
The Photon-Driven Hydrophilicity of Titania:  A Model Study Using TiO<sub>2</sub>(110) and Adsorbed Trimethyl Acetate (2003)

The behavior of H2O on clean and trimethyl acetate (TMA)-covered TiO2(110)−(1 × 1), prepared with or without oxygen vacancies and associated Ti3+, reveals the hydrophilic nature of clean surfaces and the hydrophobic nature of TMA-covered surfaces. UV irradiation of a hydrophobic surface in the presence of 10-6 Torr of O2 removes TMA and rapidly restores hydrophilicity. The presence of oxygen atom vacancies does not detectably alter the hydrophilicity of either clean or TMA-covered TiO2(110).
Detection of Degradation of Lithium-Ion Batteries with Acoustic Emission Technique (2010)

Acoustic Emission (AE) technique is employed to detect degradation events inside of lithium-ion batteries. A commercial 18650 type battery and a model half cell (Li/organic electrolyte /LiCoO2) are monitored with AE technique during charge and discharge cycles. In the commercial battery, AE events are detected during every discharge process at SOC of around 35% and 15%. These AE can be attributed to the fracture of cathode material by phase transition. In the model half cell, AE events are found early cycles in charge process owing to the SEI formation, however in discharge process detected only under high C rate.
Automatic segmentation of radiographic fiducial and seeds from X-ray images in prostate brachytherapy (2011)

Prostate brachytherapy guided by transrectal ultrasound is a common treatment option for early stage prostate cancer. Prostate cancer accounts for 28% of cancer cases and 11% of cancer deaths in men with 217,730 estimated new cases and 32,050 estimated deaths in 2010 in the United States alone. The major current limitation is the inability to reliably localize implanted radiation seeds spatially in relation to the prostate. Multimodality approaches that incorporate X-ray for seed localization have been proposed, but they require both accurate tracking of the imaging device and segmentation of the seeds. Some use image-based radiographic fiducials to track the X-ray device, but manual intervention is needed to select proper regions of interest for segmenting both the tracking fiducial and the seeds, to evaluate the segmentation results, and to correct the segmentations in the case of segmentation failure, thus requiring a significant amount of extra time in the operating room. In this paper, we present an automatic segmentation algorithm that simultaneously segments the tracking fiducial and brachytherapy seeds, thereby minimizing the need for manual intervention. In addition, through the innovative use of image processing techniques such as mathematical morphology, Hough transforms, and RANSAC, our method can detect and separate overlapping seeds that are common in brachytherapy implant images. Our algorithm was validated on 55 phantom and 206 patient images, successfully segmenting both the fiducial and seeds with a mean seed segmentation rate of 96% and sub-millimeter accuracy.
Regulated Expression of PTPRJ/CD148 and an Antisense Long Noncoding RNA in Macrophages by Proinflammatory Stimuli (2013)

PTPRJ/CD148 is a tyrosine phosphatase that has tumour suppressor-like activity. Quantitative PCR of various cells and tissues revealed that it is preferentially expressed in macrophage-enriched tissues. Within lymphoid tissues immunohistochemistry revealed that PTPRJ/CD148 co-localised with F4/80, indicating that macrophages most strongly express the protein. Macrophages express the highest basal level of ptprj, and this is elevated further by treatment with LPS and other Toll-like receptor ligands. In contrast, CSF-1 treatment reduced basal and stimulated Ptprj expression in human and mouse cells, and interferon also repressed Ptprj expression. We identified a 1006 nucleotide long noncoding RNA species, Ptprj-as1 that is transcribed antisense to Ptprj. Ptprj-as1 was highly expressed in macrophage-enriched tissue and was transiently induced by Toll-like receptor ligands with a similar time course to Ptprj. Finally, putative transcription factor binding sites in the promoter region of Ptprj were identified.
Identification of a Novel Proinflammatory Human Skin-Homing Vγ9Vδ2 T Cell Subset with a Potential Role in Psoriasis (2011)

γδ T cells mediate rapid tissue responses in murine skin and participate in cutaneous immune regulation including protection against cancer. The role of human γδ cells in cutaneous homeostasis and pathology is characterized poorly. In this study, we show in vivo evidence that human blood contains a distinct subset of proinflammatory cutaneous lymphocyte Ag and CCR6-positive Vγ9Vδ2 T cells, which is rapidly recruited into perturbed human skin. Vγ9Vδ2 T cells produced an array of proinflammatory mediators including IL-17A and activated keratinocytes in a TNF-α- and IFN-γ-dependent manner. Examination of the common inflammatory skin disease psoriasis revealed a striking reduction of circulating Vγ9Vδ2 T cells in psoriasis patients compared with healthy controls and atopic dermatitis patients. Decreased numbers of circulating Vγ9Vδ2 T cells normalized after successful treatment with psoriasis-targeted therapy. Taken together with the increased presence of Vγ9Vδ2 T cells in psoriatic skin, these data indicate redistribution of Vγ9Vδ2 T cells from the blood to the skin compartment in psoriasis. In summary, we report a novel human proinflammatory γδ T cell involved in skin immune surveillance with immediate response characteristics and with potential clinical relevance in inflammatory skin disease.
<title>Mass-spectrometer-based continuous emissions monitoring system for acid-gas emissions and DRE demonstration</title> (1993)

The objective of the work presented here was to develop a technology for continuous measurement of stack gas emissions for compounds such as HCl, SO<SUB>2</SUB>, and NO<SUB>x</SUB> that was also capable of monitoring toxic hydrocarbons. The goal was to assure operators and local communities that the emission source is routinely operating in compliance with and well within the U.S. Environmental Protection Agency guidelines. A mass spectrometer-based continuous emissions monitoring system (CEMS) and its sample extraction system developed as a result of this work are described. Results of calibration drift, linearity, and accuracy tests for HCl, SO<SUB>2</SUB>, and NO<SUB>x</SUB> are presented. Results of CEMS tests are described that show the system has the performance capabilities necessary for a relatively inexpensive and frequent DRE demonstration.
Financial Services (1994)

The provision of financial services by property consultants will obviously vary according to the expertise of the firm, its clients and any niche market in which the firm is operating. This section relies heavily on the study of the operation of Chesterton Financial, the financial services company of Chesterton International, international property consultants. Chesterton Financial deal mainly with: Most activity is in the area of debt finance.
ION EXCHANGE KINETICS OF DL-LYSINE MONOHYDROCHLORIDE ON AMBERLITE IRA-420 (1996)

ABSTRACT The ion exchange kinetics of DL-lysine monohydrochloride on Amberlite IRA-420 have been studied. Ionic diffusivity of hydroxyl anion, which is supposed to be equal to the interdiffusion coefficient, has been evaluated by fitting experimental kinetic data to a theoretical model based on the continuity equation of the CI" anion in solution filling the pores of the resin. Because of changes of both viscosity with ionic concentration and co-ion behavior in solution at high concentrations, a variation of ionic diffusivity of hydroxyl anion has been observed. In order to predict the dynamic behavior of fixed beds a simple mathematical model including both equilibrium isotherm and ionic diffusivity of hydroxyl anion has been developed. Likewise, resin regeneration using NaOH solutions has been investigated. The results show the feasibility of the procedure of purification and regeneration and they have been used to design a plant for the treatment of 50 Tm/yr of DL-lysine monohydrochloride.
Fabrication of a High‐Performance Flexible Silver–Zinc Wire Battery (2016)

Fabrication of a flexible wire battery assembled by utilizing low-cost fabrication processes and based on silver–zinc chemistry is reported. It offers unique versatility in terms of integration with wearable technologies due to its omnidirectional flexibility and improved performance characteristics. The battery is stable over 170 cycles with capacity retention above 98% and has linear capacity ranging between 1.2 and 1.8 mAh cm−1 at 0.5C discharge rate.
Inverse synthetic aperture radar imaging for concealed object detection on a naturally walking person (2014)

This paper describes the architecture of a microwave radar system intended for imaging concealed objects under clothing as a subject walks through the inspection area. The system uses the principle of inverse aperture which is achieved by a person’s movement past a stationary microwave sensor array. In the system, the vertical resolution is achieved by arranging microwave sensors vertically while the horizontal resolution is due to the subject’s horizontal motion. The positioning of the objects is achieved by employing a synchronous video sensor that allows coherent radar signal processing. A possible radar signal processing technique based on signal accumulation is described. Numerical experiments are conducted with the described object trajectory model. The influence of positioning errors attributed to the video positioning system is also modeled numerically. An experimental setup is designed and proposed to evaluate the suggested signal processing techniques on real data with an electro-mechanical scanner and single transceiver. It is suggested that the signal acquisition with the system can be accomplished using the stop motion technique, in which a series of changing stationary scenes is sampled and processed. Experimental radar images are demonstrated for stationary objects with concealed items and considered as reference images. Further development of the system is suggested.
An Outbreak of Gastroenteritis and Fever Due to<i>Listeria monocytogenes</i>in Milk (1997)

L. monocytogenes is a cause of gastroenteritis with fever, and sporadic cases of invasive listeriosis may be due to unrecognized outbreaks caused by contaminated food.