gebhart/patrepeval huggingface dataset:
Beta-2-microglobulin amyloidosis and renal bone disease. (1991)

Dialysis-related amyloidosis is a highly invalidating complication of chronic dialysis patients. Clinically and radiologically, the complication generally becomes manifest after more than 5-10 years of dialysis treatment. It is characterized by chronic arthralgias, periarticular soft-tissue swelling, carpal tunnel syndrome, diffuse destructive arthropathy and spondylarthropathy, lytic bone lesions, and sometimes pathologic fractures. Biochemically, amyloid deposits are mainly composed of beta-2-microglobulin fibrils together with the P component and glucose aminoglycans, the latter two being associated with all types of amyloidosis. The pathogenesis of the syndrome is still poorly understood. Recently, evidence has been provided for the possibility that beta-2-microglobulin is not a passive bystander, but an active player in the initiation and progression of the disease. The potential role of the dialysis technique, including the mode of dialysis and the biocompatibility of dialysis membrane used, is also under discussion.
Douglas fir tussock moth pheromone: identification of a diene analog of the principal attractant and synthesis of stereochemically defined 1,6-, 2,6-, and 3,6-heneicosadien-11-ones (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDouglas fir tussock moth pheromone: identification of a diene analog of the principal attractant and synthesis of stereochemically defined 1,6-, 2,6-, and 3,6-heneicosadien-11-onesLawrence M. Smith, Ronald G. Smith, Thomas M. Loehr, G. Doyle Daves Jr., Gary E. Daterman, and Robert H. WohlebCite this: J. Org. Chem. 1978, 43, 12, 2361–2366Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://pubs.acs.org/doi/10.1021/jo00406a012https://doi.org/10.1021/jo00406a012research-articleACS PublicationsRequest reuse permissionsArticle Views266Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Circuit simulation on shared-memory multiprocessors (1988)

Reports the parallelization on a shared-memory vector multiprocessor of the computationally intensive components of a circuit simulator-matrix assembly (including device model evaluation) and the unstructured sparse linear system solution. A theoretical model is used to predict the performance of the lock-synchronized parallel matrix assembly, and the results are compared to experimental measurements. Alternate approaches to efficient sparse matrix solution are contrasted, highlighting the impact of the matrix representation/access strategy on achievable performance, and medium-grained approach with superior performance is introduced. The techniques developed have been incorporated into a prototype parallel implementation of the production circuit simulator ADVICE on the Alliant FX/8 multiprocessor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Shared probe design and existing microarray reanalysis using PICKY (2010)

Shared probes allow expressed gene family members to be detected; this capability is generally more desirable than not knowing anything about these genes. Shared probes also enable the design of cross-genome microarrays, which facilitate multiple species identification in environmental samples. The new nonlinear salt effect calculation significantly increases the precision of probes at a lower buffer salt concentration, and the probe reanalysis function improves existing microarray result interpretations.
Genetic and physical analysis of the chicken tk gene. (1984)

Several aspects of the structure of the chicken thymidine kinase gene (tk) have been resolved as a result of genetic experiments and nucleotide sequencing. Deletion mapping established the locations of two functional boundaries in a region thought to correspond to the 5' terminus of the gene. One such boundary coincides with a transcriptional promoter, and the other coincides with the translation start codon of the chicken tk polypeptide. Similar deletion mapping assays identified a functional boundary at the 3' terminus of the gene. DNA sequence analysis confirms the prediction that this 3' region encodes the carboxyl terminus of the tk polypeptide. A recombinant cDNA clone complementary to genomic tk sequences was isolated. A comparison between genomic and cDNA sequences reveals the locations of six intervening sequences and allows prediction of the complete amino acid sequence of the chicken tk polypeptide.
PCR from fungal spores after microwave treatment (1996)

We describe a fast template preparation method for PCR amplification from fungal spores using microwave irradiation. The method is useful when the availability of fungal material is restricted or the number of processed samples is large.
Methods of studying breast motion in sports bras: a review (2011)

There is exponentially increasing number of research publications studying breast motion in sports bras. However, there are large varieties of their methods and findings. To critically evaluate the consistency and limitations of previous breast motion studies, a systematic review of all articles on breast motion in sports bras was performed. A total of 17 fully extracted studies included 216 subjects, aged from 20 to 60 with bra cup sizes from A to J. They participated in only four types of activities with or without bras, but not in randomized controlled trials. Most studies focused on the vertical nipple movements, but seldom examined the three-dimensional breast velocity, acceleration, and trajectory. The sample sizes and the types of activities were limited. The reference frames were not stable in most studies. To study the realistic breast movements in the future, a standardized local coordinate system will be needed.
Inactivation of NF-κB by 3,3′-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells (2007)

Constitutive activation of Akt or nuclear factor-kappaB (NF-kappaB) has been reported to play a role in de novo resistance of cancer cells to chemotherapeutic agents, which is a major cause of treatment failure in cancer chemotherapy. Previous studies have shown that 3,3'-diindolylmethane (DIM), a major in vivo acid-catalyzed condensation product of indole-3-carbinol, is a potent inducer of apoptosis, inhibitor of tumor angiogenesis, and inactivator of Akt/NF-kappaB signaling in breast cancer cells. However, little is known regarding the inactivation of Akt/NF-kappaB that leads to chemosensitization of breast cancer cells to chemotherapeutic agents, such as Taxotere. Therefore, we examined whether the inactivation Akt/NF-kappaB signaling caused by B-DIM could sensitize breast cancer cells to chemotherapeutic agents both in vitro and in vivo. MDA-MB-231 cells were simultaneously treated with 15 to 45 micromol/L B-DIM and 0.5 to 1.0 nmol/L Taxotere for 24 to 72 h. Cell growth inhibition assay, apoptosis assay, electrophoretic mobility shift assay, and Western blotting were done. The combination treatment of 30 micromol/L B-DIM with 1.0 nmol/L Taxotere elicited significantly greater inhibition of cell growth compared with either agent alone. The combination treatment induced greater apoptosis in MDA-MB-231 cells compared with single agents. Moreover, we found that NF-kappaB activity was significantly decreased in cells treated with B-DIM and Taxotere. We also have tested our hypothesis using transfection studies, followed by combination treatment with B-DIM/Taxotere, and found that combination treatment significantly inhibited cell growth and induced apoptosis in MDA-MB-231 breast cancer cells mediated by the inactivation of NF-kappaB, a specific target in vitro and in vivo. These results were also supported by animal experiments, which clearly showed that B-DIM sensitized the breast tumors to Taxotere, which resulted in greater antitumor activity mediated by the inhibition of Akt and NF-kappaB. Collectively, our results clearly suggest that inhibition of Akt/NF-kappaB signaling by B-DIM leads to chemosensitization of breast cancer cells to Taxotere, which may contribute to increased growth inhibition and apoptosis in breast cancer cells. The data obtained from our studies could be a novel breakthrough in cancer therapeutics by using nontoxic agents, such as B-DIM, in combination with other conventional therapeutic agents, such as Taxotere.
Xen-Based HPC: A Parallel I/O Perspective (2008)

Virtualization using Xen-based virtual machine environment has yet to permeate the field of high performance computing (HPC). One major requirement for HPC is the availability of scalable and high performance I/O. Conventional wisdom suggests that virtualization of system services must lead to degraded performance. In this presentation, we take on a parallel I/O perspective to study the viability of Xen-based HPC for data-intensive programs. We have analyzed the overheads and migration costs for parallel I/O programs in a Xen-based virtual machine cluster. Our analysis covers PVFS-based parallel I/O over two different networking protocols: TCP-based Gigabit Ethernet and VMM-bypass InfiniBand. Our experimental results suggest that network processing in Xen-based virtualization can significantly impact the performance of Parallel I/O. By carefully tuning the networking layers, we have demonstrated the following for Xen-based HPC I/O: (I) TCP offloading can help achieve low overhead parallel I/O; (2) parallel reads and writes require different network tuning to achieve good I/O bandwidth; and (3) Xen-based HPC environment can support high performance parallel I/O with both negligible overhead and little migration cost.
MicroRNA markers for forensic body fluid identification obtained from microarray screening and quantitative RT-PCR confirmation (2010)

MicroRNAs (miRNAs) are non-protein coding molecules with important regulatory functions; many have tissue-specific expression patterns. Their very small size in principle makes them less prone to degradation processes, unlike messenger RNAs (mRNAs), which were previously proposed as molecular tools for forensic body fluid identification. To identify suitable miRNA markers for forensic body fluid identification, we first screened total RNA samples derived from saliva, semen, vaginal secretion, and venous and menstrual blood for the expression of 718 human miRNAs using a microarray platform. All body fluids could be easily distinguished from each other on the basis of complete array-based miRNA expression profiles. Results from quantitative reverse transcription PCR (RT-PCR; TaqMan) assays for microarray candidate markers confirmed strong over-expression in the targeting body fluid of several miRNAs for venous blood and several others for semen. However, no candidate markers from array experiments for other body fluids such as saliva, vaginal secretion, or menstrual blood could be confirmed by RT-PCR. Time-wise degradation of venous blood and semen stains for at least 1 year under lab conditions did not significantly affect the detection sensitivity of the identified miRNA markers. The detection limit of the TaqMan assays tested for selected venous blood and semen miRNA markers required only subpicogram amounts of total RNA per single RT-PCR test, which is considerably less than usually needed for reliable mRNA RT-PCR detection. We therefore propose the application of several stable miRNA markers for the forensic identification of blood stains and several others for semen stain identification, using commercially available TaqMan assays. Additional work remains necessary in search for suitable miRNA markers for other forensically relevant body fluids.
Temperature sensitivity of silica micro-resonators (2008)

Optical resonance shifts are measured against temperature changes for different silica beads ranging from 80 to 450 µm in diameter. A micro-bead is fabricated by hydrogen flame fusing the tip of a single mode silica fibre/taper, and coupled to a fibre taper of submicrometre diameter. The coupling system in whispering-gallery modes is placed in an insulated cell. The air in the cell is slowly heated up from room temperature to about 10K higher, and red shifts of a resonance wavelength during the heating process are recorded. Linear dependence of the wavelength shift versus the temperature rise is observed for all the tested micro-resonators. The measured sensitivity for beads greater than 200 µm in size closely matches the analytical value based on bulk material properties of silica thermal expansion and the thermo-optic effect. For smaller micro-beads, however, the measured sensitivity increases with shrinking bead size. The ultra-high resolution of such a kind of temperature micro-sensor and its potential applications are addressed. (Some figures in this article are in colour only in the electronic version)
Radial Basis Function Based Neural Network for Motion Detection in Dynamic Scenes (2013)

Motion detection, the process which segments moving objects in video streams, is the first critical process and plays an important role in video surveillance systems. Dynamic scenes are commonly encountered in both indoor and outdoor situations and contain objects such as swaying trees, spouting fountains, rippling water, moving curtains, and so on. However, complete and accurate motion detection in dynamic scenes is often a challenging task. This paper presents a novel motion detection approach based on radial basis function artificial neural networks to accurately detect moving objects not only in dynamic scenes but also in static scenes. The proposed method involves two important modules: a multibackground generation module and a moving object detection module. The multibackground generation module effectively generates a flexible probabilistic model through an unsupervised learning process to fulfill the property of either dynamic background or static background. Next, the moving object detection module achieves complete and accurate detection of moving objects by only processing blocks that are highly likely to contain moving objects. This is accomplished by two procedures: the block alarm procedure and the object extraction procedure. The detection results of our method were evaluated by qualitative and quantitative comparisons with other state-of-the-art methods based on a wide range of natural video sequences. The overall results show that the proposed method substantially outperforms existing methods with Similarity and F1 accuracy rates of 69.37% and 65.50%, respectively.
AQUINAS ON INFINITE REGRESS (1962)

AQUINAS ON INFINITE REGRESS Get access J. OWENS, C.Ss.R. J. OWENS, C.Ss.R. Pontifical Institute of Mediaeval StudiesToronto Search for other works by this author on: Oxford Academic Google Scholar Mind, Volume LXXI, Issue 282, April 1962, Pages 244–246, https://doi.org/10.1093/mind/LXXI.282.244 Published: 01 April 1962
Synthesis of Hydroxyapatite by an Oxidative Decomposition Method of Calcium Chelate (1992)

Preparation of hydroxyapatite (Hap) was investigated by a homogeneous precipitation technique. The precipitates were obtained by mixing solutions of Ca (NO3)2, (NH4)2HPO4, EDTA-Na and H2O2 at 90°C. The products were identified as carbonate-containing hydroxyapatite by the X-ray diffraction and IR spectrometry. When pH value of the reacting solution was higher than 10, Ca/P molar ratio of the precipitate was 1.67. Synthesized Hap powders by this method had specific surface area of 5-35m2/g, and the Hap particles showed clear hexagonal pyramidal ideomorphic shapes.
A Survey of Deep Learning-Based Object Detection (2019)

Object detection is one of the most important and challenging branches of computer vision, which has been widely applied in people’s life, such as monitoring security, autonomous driving and so on, with the purpose of locating instances of semantic objects of a certain class. With the rapid development of deep learning algorithms for detection tasks, the performance of object detectors has been greatly improved. In order to understand the main development status of object detection pipeline thoroughly and deeply, in this survey, we analyze the methods of existing typical detection models and describe the benchmark datasets at first. Afterwards and primarily, we provide a comprehensive overview of a variety of object detection methods in a systematic manner, covering the one-stage and two-stage detectors. Moreover, we list the traditional and new applications. Some representative branches of object detection are analyzed as well. Finally, we discuss the architecture of exploiting these object detection methods to build an effective and efficient system and point out a set of development trends to better follow the state-of-the-art algorithms and further research.
Zeolite-<i>like</i> Metal−Organic Frameworks (ZMOFs) Based on the Directed Assembly of Finite Metal−Organic Cubes (MOCs) (2009)

Two zeolite-like metal-organic frameworks (ZMOFs) with lta- and ast- topologies, zeolitic nets that can be interpreted as augmented edge-transitive 8-connected nets, are targeted through directed self-assembly of metal-organic cubes (MOCs) as supermolecular building blocks (SBBs).
Randomized, double-blind, placebo-controlled trial of phenylbutyrate in spinal muscular atrophy (2006)

Phenylbutyrate was not effective at the regimen, schedule, and duration used in this study.
Enabling Design Methodologies and Future Trends for Edge AI: Specialization and Codesign (2021)

This work is an introduction and a survey for the Special Issue on Machine Intelligence at the Edge. The authors argue that workloads that were formerly performed in the cloud are increasingly moving to resource-limited edge computing systems, which raises a new set of challenges for machine learning as well as new opportunities. The topic is introduced by means of building blocks ranging from edge fundamentals to edge AI enabling methodologies as well as future trends and challenges.
Byzantine empresses: women and power in Byzantium, AD 527-1204 (1999)

Byzantine Empresses provides a series of biographical portraits of the most significant Byzantine women who ruled or shared the throne between 527 and 1204. It presents and analyses the available historical data in order to outline what these empresses did, what the sources thought they did, and what they wanted to do.
Exploring genomic profiles of hepatocellular carcinoma (2011)

Gene expression profiling using microarray technologies provides a powerful approach to understand complex biological systems and the pathogenesis of diseases. In the field of liver cancer research, a number of genome-wide profiling studies have been published. These studies have provided gene sets, that is, signature, which could classify tumors and predict clinical outcomes such as survival, recurrence, and metastasis. More recently, the application of genomic profiling has been extended to identify molecular targets, pathways, and the cellular origins of the tumors. Systemic and integrative analyses of multiple data sets and emerging new technologies also accelerate the progress of the cancer genomic studies. Here, we review the genomic signatures identified from the genomic profiling studies of hepatocellular carcinoma (HCC), and categorize and characterize them into prediction, phenotype, function, and molecular target signatures according to their utilities and properties. Our classification of the signatures would be helpful to understand and design studies with extended application of genomic profiles.
Human Herpesvirus 6 and Chronic Fatigue Syndrome (1992)

The cause of chronic fatigue syndrome (CFS) is still enigmatic. Using indirect immunofluorescence testing for measuring antibody against human herpesvirus 6 (HHV-6), this study investigated the association of CFS with infection by HHV-6. Seventeen patients (group A) fulfilling the Centers for Disease Control (CDC) definition for CFS were compared with eight patients (group B) with chronic fatigue but not meeting the CDC criteria. No significant difference was found between the two groups for 30 parameters including sex, age, exposure to children and serology for Epstein-Barr virus, cytomegalovirus, herpes simplex virus, and toxoplasma. Univariate analysis showed that patients in group A complained more frequently of a sore throat, headache and of recurrent type of fatigue. These three parameters are discriminant in identifying patients who will meet the CDC case definition of CFS. The titre of antibody against HHV-6 in group A (1:99) was significantly higher than in group B (1:15) (P=0.007). Elevated HHV-6 titres suggests that this virus could be a cofactor in the pathogenesis of CFS.
Hybrid MnO<sub>2</sub>–disordered mesoporous carbon nanocomposites: synthesis and characterization as electrochemical pseudocapacitor electrodes (2009)

MnO2–mesoporous carbon hybrid nanocomposites were synthesized to achieve high values of redox pseudocapacitance at scan rates of 100 mV s−1. High-resolution transmission electron microscopy (HRTEM) along with energy dispersive X-ray spectroscopy (EDX) demonstrated that ∼1 nm thick MnO2 nanodomains, resembling a conformal coating, were uniformly distributed throughout the mesoporous carbon structure. HRTEM and X-ray diffraction (XRD) showed formation of MnO2 nanocrystals with lattice planes corresponding to birnessite. The electrochemical redox pseudocapacitance of these composite materials in aqueous 1 M Na2SO4 electrolyte containing as little as 2 wt% MnO2 exhibited a high gravimetric MnO2 pseudocapacitance (CMnO2) of 560 F gMnO2−1. Even for 30 wt% MnO2, a high CMnO2 of 137 F gMnO2−1 was observed at 100 mV s−1. Sodium ion diffusion coefficients on the order of 10−9 to 10−10 cm2 s−1 were measured using chronoamperometry. The controlled growth and conformal coating of redox-active MnO2–mesoporous carbon composites offer the potential for achieving high power energy storage with low cost materials.