gebhart/patrepeval huggingface dataset:
99mTc-apcitide scintigraphy and the detection of acute deep vein thrombosis. (2000)

binding peptide. The authors reported a sensitivity of 86.4% in the detection of ADVT when early and delayed sets of images were analyzed together. However, the inclusion of patients (7/22) with discordant results of scintigraphy (i.e., association of negative and positive results on the 3 sets of images) may be misleading and should be discussed. Five of 7 patients displayed late positivity only. This result could be explained by a low activity of the thrombus. Inclusion of these patients among the positive results can be accepted. However, 2 patients had early positivity only, with negative results at 120 min, and were included when all datasets were considered. The critical question is why does a thrombus result in early positive and late negative images? This could be explained by the hemodynamic action of the thrombus, which, though no longer active, delays the regional blood-pool clearance. However, other conditions that mimic ADVT in daily practice may also delay the regional blood-pool clearance (e.g., calf cellulitis and calf hematoma). Therefore, to include patients with positive early results only is questionable and may have deleterious therapeutic implications such as prescription of an anticoagulant in a patient with calf hematoma. Takatsu and Fujiwara (2) correctly stated in their editorial that contrast-enhanced venography, although considered the gold standard, has real limitations. They argued that the accuracy of 99m Tc-apcitide scintigraphy for detecting ADVT might be much higher than that obtained in this study. Their statement is valid for only 2 of 17 patients with late positive scintigraphy and negative contrast-enhanced venography. Their statement is not relevent however for the 3 patients (of 22) with proven ADVT and negative scintigraphy. Therefore, the sensitivity of 99mTc-apcitide scintigraphy to detect ADVT is lower than contrast-enhanced venography in this small series of patients. The sensitivity seems to be 76% when early positivity only is not considered. If the 2 patients with late positive scintigraphy and negative contrast-enhanced venography were assumed to have ADVT that was not detected by the gold-standard technique, this would lead to a sensitivity of 78%
Developing Industry-Ready Human Resources in India: A Socio-Technical Dimension of Competitiveness (2013)

Developing industry-ready human resources (HRs) is a big challenge for India in the prevailing socio-technical system. At the cross-roads of competitive business practices, Indian industries demand huge job openings; whereas, the young Indian professionals have less or no jobs. This is the outcome of a mismatch between the demand and supply of HRs of the HR development (HRD) centres with respect to the industry. A sustainable business model for developing HRs to leverage employable people to the market is described in this paper. The purpose of the paper is to propagate design thinking amongst the practicing managers, professionals, academicians, researchers, students and the society at large. The careful design of HRD process eliminates all types of mismatches, suitably capturing the voice of the industries, for a better ‘fit for use’ or quality. The paper is based on the concepts of ‘product design and development’. Further, it is generalised through a case study, based on the secondary data obtained from different company websites, in the test bed of the Golden Triangle of Odisha under the tourism industry. The results, collaboratively derived from the practices and literature, look very promising. The recommendations being agreeable to both the supply and demand sides, yield confidence for the harmless implementation of the model in any industry.
Investigation of YBCO Coated Conductors for Fault Current Limiter Applications (2007)

The switching behavior of second generation (2G) HTS wires with a coated conductor (CC) architecture for application in fault current limiters (FCL) has been studied. Measurements have been performed on short pieces of meter length, as well as on bifilar coils wound from 20 meters of CC. CCs with and without stainless steel stabilizers have been compared regarding the temperature reached after applying a constant voltage per length to the conductor for a certain time (typically 50 ms). Three coils from stainless steel stabilized wires have been connected in series to demonstrate uniform switching of the individual coils in a single phase FCL model with 120 kVA nominal power. The response to transient currents has been investigated by applying currents above the critical current Ic with different amplitudes and measuring the time at which an irreversible voltage increase occurs. All CCs investigated proved well suitable for FCL applications exhibiting the required uniformity and excellent current limiting performance.
Human metapneumovirus and respiratory syncytial virus infections in older children with cystic fibrosis (2006)

The infection rates and clinical impact observed for hMPV were comparable to that for RSV in CF children 7-18 years of age.
Astrocytes from Na<sup>+</sup>-K<sup>+</sup>-Cl<sup>−</sup>cotransporter-null mice exhibit absence of swelling and decrease in EAA release (2002)

We reported previously that inhibition of Na(+)-K(+)-Cl(-) cotransporter isoform 1 (NKCC1) by bumetanide abolishes high extracellular K(+) concentration ([K(+)](o))-induced swelling and intracellular Cl(-) accumulation in rat cortical astrocytes. In this report, we extended our study by using cortical astrocytes from NKCC1-deficient (NKCC1(-/-)) mice. NKCC1 protein and activity were absent in NKCC1(-/-) astrocytes. [K(+)](o) of 75 mM increased NKCC1 activity approximately fourfold in NKCC1(+/+) cells (P < 0.05) but had no effect in NKCC1(-/-) astrocytes. Intracellular Cl(-) was increased by 70% in NKCC1(+/+) astrocytes under 75 mM [K(+)](o) (P < 0.05) but remained unchanged in NKCC1(-/-) astrocytes. Baseline intracellular Na(+) concentration ([Na(+)](i)) in NKCC1(+/+) astrocytes was 19.0 +/- 0.5 mM, compared with 16.9 +/- 0.3 mM [Na(+)](i) in NKCC1(-/-) astrocytes (P < 0.05). Relative cell volume of NKCC1(+/+) astrocytes increased by 13 +/- 2% in 75 mM [K(+)](o), compared with a value of 1.0 +/- 0.5% in NKCC1(-/-) astrocytes (P < 0.05). Regulatory volume increase after hypertonic shrinkage was completely impaired in NKCC1(-/-) astrocytes. High-[K(+)](o)-induced (14)C-labeled D-aspartate release was reduced by approximately 30% in NKCC1(-/-) astrocytes. Our study suggests that stimulation of NKCC1 is required for high-[K(+)](o)-induced swelling, which contributes to glutamate release from astrocytes under high [K(+)](o).
Freestall barn design and management for cow comfort (1998)

Proper design, construction, and care of freestalls are essential to cows using the stalls and realizing their potential benefits for comfort and health. Freestall dimensions depend upon particular designs and are compromises between ensuring optimum cleanliness and providing a spacious area for the ultimate in cow comfort. Freestalls designed to meet these fundamental needs will be most used. Most likely, no perfect freestall design exists. Rather, several freestall designs may satisfy the basic requirements of the cow perfectly well!; Dairy Day, 1998, Kansas State University, Manhattan, KS, 1998;
Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis (2017)

Atherosclerosis, the progressive buildup of plaque within arterial blood vessels, can lead to fatal downstream events, such as heart attack or stroke. A key event contributing to the development of atherosclerosis is the infiltration of monocytes and its associated inflammation, as well as the formation of lipid-laden macrophage foam cells within the vessel wall. IL-37 is recognized as an important anti-inflammatory cytokine expressed especially by immune cells. This study was undertaken to elucidate the role of macrophage-expressed IL-37 in reducing the production and effects of proinflammatory cytokines, preventing foam cell formation, and reducing the development of atherosclerosis. Expression of human IL-37 was achieved with a macrophage-specific overexpression system, using the CD68 promoter in mouse primary bone marrow-derived macrophages via retroviral transduction. Macrophage IL-37 expression in vitro resulted in decreased mRNA (e.g., IL-1B, IL-6, and IL-12) and secreted protein production (e.g., IL-6, M-CSF, and ICAM-1) of key inflammatory mediators. IL-37 expression also inhibited macrophage proliferation, apoptosis, and transmigration, as well as reduced lipid uptake, compared with controls in vitro. The in vivo effects of macrophage-expressed IL-37 were investigated through bone marrow transplantation of transduced hematopoietic stem cells into irradiated atherosclerosis-prone <i>Ldlr<sup>-/-</sup></i> mice. After 10 wk on a high-fat/high-cholesterol diet, mice with IL-37-expressing macrophages showed reduced disease pathogenesis, which was demonstrated by significantly less arterial plaque development and systemic inflammation compared with control mice. The athero-protective effect of macrophage-expressed IL-37 has implications for development of future therapies to treat atherosclerosis, as well as other chronic inflammatory diseases.
Polyfluorobenzopinacols (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolyfluorobenzopinacolsRobert Filler and Hyung H. KangCite this: J. Org. Chem. 1975, 40, 8, 1173–1175Publication Date (Print):April 1, 1975Publication History Published online1 May 2002Published inissue 1 April 1975https://pubs.acs.org/doi/10.1021/jo00896a040https://doi.org/10.1021/jo00896a040research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Zinc-dependent cleavage in the catalytic core of the hammerhead ribozyme: evidence for a pH-dependent conformational change (2003)

We have characterized a novel Zn2+-catalyzed cleavage site between nucleotides C3 and U4 in the catalytic core of the hammerhead ribozyme. In contrast to previously described divalent metal-ion-dependent cleavage of RNA, U4 cleavage is only observed in the presence of Zn2+. This new cleavage site has an unusual pH dependence, in that U4 cleavage products are only observed above pH 7.9 and reach a maximum yield at about pH 8.5. These data, together with the fact that no metal ion-binding site is observed in proximity to the U4 cleavage site in either of the crystal structures, point toward a pH-dependent conformational change in the hammerhead ribozyme. We have described previously Zn2+-dependent cleavage between G8 and A9 in the hammerhead ribozyme and have discovered that U4 cleavage occurs only after A9 cleavage. To our knowledge, this is the first example of sequential cleavage events as a possible regulatory mechanism in ribozymes.
DNS64: DNS Extensions for Network Address Translation from IPv6 Clients to IPv4 Servers (2011)

DNS64 is a mechanism for synthesizing AAAA records from A records.DNS64 is used with an IPv6/IPv4 translator to enable client-server communication between an IPv6-only client and an IPv4-only server, without requiring any changes to either the IPv6 or the IPv4 node, for the class of applications that work through NATs.This document specifies DNS64, and provides suggestions on how it should be deployed in conjunction with IPv6/IPv4 translators.
The mind-brain continuum : sensory processes (1996)

The brain as a closed system modulated by the senses, R. Llinas and D. Pare making images and creating subjectivity, A.R. Damasio and H. Damasio illusions of body image - what they reveal about human nature, V.S. Ramachandran et al neural representations, experience and change, M.M. Merzenich and R.C. deCharms neurotransmitter receptor regulation and its role in synaptic plasticity and stabilization, P.W. Hickmott and M. Constantine-Paton neuronal synchronization - a solution to the binding problem?, W. Singer the binding problem of neural networks, C. von der Malsburg recognition and representation of visual objects in primates - psychophysics and physiology, N.K. Logothetis and D.L. Sheinberg olfactory perception and memory, H. Eichenbaum perceptual interpretation and the neurobiology of perception, A.S. Bregman formation of perceptual objects from the timing of neural responses - target-range images in bat sonar, J.A. Simmons audition - cognitive psychology of music, S. McAdams toward a neurobiology of the mind, P.S. Churchland.
Radiolabeling and dose fixation study of oral alpha-ketoglutarate as a cyanide antidote in healthy human volunteers (2010)

Aqueous dilution improves the bioavailability of A-KG in humans.
Toward Automated Interpretation of Satellite Imagery for Navy Shipboard Applications (1992)

The U.S. Navy has plans to develop an automated system to analyze satellite imagery aboard its ships at sea. Lack of time for training, in combination with frequent personnel rotations, precludes the building of extensive imagery interpretation expertise by shipboard personnel. A preliminary design starts from pixel data from which clouds are classified. An image segmentation is performed to assemble and isolate cloud groups, which are then identified (e.g., as a cold front) using neural networks. A combination of neural networks and expert systems is subsequently used to transform key information about the identified cloud patterns as inputs to an expert system that provides sensible weather information, the ultimate objective of the imagery analysis.
Chromatin Immunoprecipitation Assay (2004)

Association between proteins and DNA is crucial for many vital cellular functions such as gene transcription, DNA replication and recombination, repair, segregation, chromosomal stability, cell cycle progression, and epigenetic silencing. It is important to know the genomic targets of DNA-binding proteins and the mechanisms by which they control and guide gene regulation pathways and cellular proliferation. Chromatin immunoprecipitation (ChIP) is an important technique in the study of protein-gene interactions. Using ChIP, DNA-protein interactions are studied within the context of the cell. The basic steps in this technique are fixation, sonication, immunoprecipitation, and analysis of the immunoprecipitated DNA. Although ChIP is a very versatile tool, the procedure requires the optimization of reaction conditions. Several modifications to the original ChIP technique have been published to improve the success and to enhance the utility of this procedure. This review addresses the critical parameters and the variants of ChiP as well as the different analytical tools that can be combined with ChIP to enable better understanding of DNA-protein interactions in vivo.
Au Courant - November 2009 (2009)

Newsletter of the Thomas G. Carpenter Library
Immunocontraceptive Effects on Female Rabbits Infected with Recombinant Myxoma Virus Expressing Rabbit ZP2 or ZP3 (2005)

Recombinant myxoma viruses expressing rabbit zona pellucida 2 (rZP2) or rabbit zona pellucida 3 (rZP3) glycoproteins were constructed and tested in domestic rabbits to assess their potential to induce autoimmune infertility. The recombinant virus expressing rZP2 had no effect on fertility or ovarian histology, despite all animals developing antibodies against the rZP2 antigen. However, recombinant viruses expressing rZP3 induced infertility in 70% of animals at the first breeding. Serum antibodies were relatively short-lived, but antibody was bound to zona pellucida of all rabbits from Day 10 onward. There was no obvious correlation between infertility and rZP3 antibody titer. There was a transient inflammatory response in the ovaries of rZP3-immunized rabbits at Day 15 but no T-cell response to rZP3 could be detected at any time. Dysfunctional follicular formation was present in ovaries from rabbits infected with rZP3-expressing viruses 15-40 days postinfection but this had disappeared at later time points. A recombinant myxoma virus expressing a modified rZP3 antigen with the C-terminal hydrophobic putative anchor sequence deleted was also tested. This virus did not induce either infertility or an antibody response against the zona pellucida. Thus, the context of antigen presentation was crucial for an autoimmune response.
New Developments in the Commercial Utilization of Lignosulfonates (2010)

This chapter contains sections titled: Introduction Lignosulfonates Lignosulfonate Production Environmental Issues Lignosulfonates as Stabilizers for Emulsions and Suspoemulsions Superplasticizers for Concrete Summary Acknowledgements References
Einleitung (1993)

Die Huichol-Indianer in Mexiko beten und bieten ihren Göttern Tiere als Opfer dar. Ihre Gesänge „halten die Welt im Gleichgewicht“.1 In Westafrika feiert das Volk der Sefwi in Ghana ein dreitägiges Yam-Fest und besucht ausgewählte Plätze im Regenwald. Eine Gruppe Männer wird vom Häuptling des Stammes und einem Medizinmann zum Wald geführt. Sie tragen kleine Hocker oder „heilige Stühle“ mit sich, die aus einem einzigen Stück Holz geschnitten sind. Die Stühle — für die Sefwi Symbole ihrer Ahnen und ihrer Vergangenheit — werden in „magischen Gärten“ aufgestellt, wo die mythischen Hüter des Waldes leben. Palmwein und Schnaps werden auf den Boden gegossen, und den unsichtbaren Hütern und den Seelen der toten Sefwi-Ahnen wird Nahrung angeboten.2 In Australien bemalt eine Aborigines-Frau ein Stück Rinde; manchmal malt sie auch auf Felsen oder in Höhlen, wie es ihre Vorfahren bereits vor 40’000 Jahren, in der „Traumzeit“, taten, als nach Glauben der Ureinwohner das Leben begann. Lange bevor sich vor ca. 5000 Jahren die Schriftsprache entwickelte, gaben die Aborigines von Generation zu Generation die Geschichte weiter, wie „Warramurrungudji aus dem Meer kam und das Land schuf. Als eine Frau in menschlicher Gestalt gebar sie die Menschen und gab ihnen ihre Sprachen. Auch andere Schöpferwesen wurden ins Leben gerufen, so Ginga, das riesige Ahnenkrokodil, und Marrawuiti, der Seeadler. Dieser Schöpfungsakt ihrer Vorfahren brachte sie in dieses Land.“3 Hoch oben im Himalaya, auf dem höchsten Berg der Erde schmilzt der Schnee auf dem Sagarmatha (Mount Everest). Der Schnee von der Mutter des Meeres, die wörtliche Übersetzung des Sanskrit-Wortes sagarmatha, bewegt sich langsam den Berghang hinunter, um die Flüsse zu füllen, bis er schließlich Gangamatha, Mutter Ganges, den heiligen indischen Strom, erreicht. Die heiligen Wasser strömen dann weiter, dem großen Ozean entgegen. Weit weg, auf einem anderen Kontinent, singen und tanzen die Mamas, die Hohepriester der Kogi, auf ihren Schneefeldern und beten, daß sie, wenn sie sterben, zur Quelle allen Lebens zurückkehren — zum höchsten Schneegipfel in der Sierra-Nevada-Gebirgskette in Nordkolumbien — in das Land der Mutter.
Effect of Antifreeze Proteins on the Nucleation, Growth, and the Memory Effect during Tetrahydrofuran Clathrate Hydrate Formation (2006)

The inhibition activities of two antifreeze proteins (AFPs) on the formation of tetrahydrofuran (THF) clathrate hydrate have been tested. AFPs from fish (wfAFP) and insect (CfAFP) changed the morphology of growing THF hydrate crystals. Also, both AFPs showed higher activities in inhibiting the formation THF hydrate than a commercial kinetic inhibitor, poly(vinylpyrrolidone) (PVP). Strikingly, both AFPs also showed the ability to eliminate the "memory effect" in which the crystallization of hydrate occurs more quickly after the initial formation. This is the first report of molecules that can inhibit the memory effect. Since the homogeneous nucleation temperature for THF hydrate was measured to be 237 K, close to that observed for ice itself, the action of kinetic inhibitors must involve heterogeneous nucleation. On the basis of our results, we postulate a mechanism for heterogeneous nucleation, the memory effect and its elimination by antifreeze proteins.
New structure for high Q-factor printed antenna in wireless power transmission (2017)

In this paper, a new and novel printed structure is proposed to obtain high quality factor (Q-factor) coil antenna in wireless power transmission system. The main idea to achieve high quality factor is “adjusted line pitch and width” with respect to outer diameters. The line pitch and width of the printed pattern are gradually increased in proportion with outer diameter. By using this design method, the Q-factor is increased about 21.8% in comparison with conventionally designed antenna.
Polychromatic simultaneous WDXRF for chemical state analysis using laboratory X‐ray source (2017)

The authors have started the development of a new scanning‐free, wavelength‐dispersive X‐ray fluorescence spectrometer, which uses a silicon strip detector instead of a goniometer, a slit, flat analyzing crystal, and laboratory X‐ray source. The X‐rays dispersed by the slit and flat analyzing crystal are detected simultaneously by different silicon strip detector channels, and a high energy resolution is achieved by limiting the measurement range. In the spectrometer designed for Cr, Mn, and Fe in the range from 5.38 to 6.64 keV, an energy resolution of 3.9 eV for Fe Kα 1 was obtained, and it was observed that KMnO 4 (VII) is different from MnO (II) in the peak energy of Mn Kβ 1,3 . Furthermore, a Kβ' satellite peak on the low‐energy side of Mn Kβ 1,3 was clearly observed, and the difference in behavior of Kβ' was investigated. Another similar investigation of Cr 2 O 3 (III) and K 2 CrO 4 (VI) was performed. These results indicate that the new wavelength‐dispersive X‐ray fluorescence spectrometer has a high energy resolution and is applicable to the chemical state analysis of 3d transition elements, which is obtained by analyzing the details of the Kβ peak at the scale of a few eV. Copyright © 2017 John Wiley & Sons, Ltd.
Clerks and Craftsmen in China and the West. Lectures and Addresses on the History of Science and Technology. By Joseph Needham. New York: Cambridge University Press, 1970. xix, 418 pp. Bibliography, Plates, Index. $22.50. (1971)

Clerks and Craftsmen in China and the West. Lectures and Addresses on the History of Science and Technology. By Joseph Needham. New York: Cambridge University Press, 1970. xix, 418 pp. Bibliography, Plates, Index. $22.50. - Volume 30 Issue 2
ChemInform Abstract: Nanoalloy Catalysts for Electrochemical Energy Conversion and Storage Reactions (2014)

Abstract Review: focus on Pt‐based nanoalloys; 132 refs.