gebhart/patrepeval huggingface dataset:
Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis (2014)

The aim of this study was to investigate the significance of the microRNA miR-197 expression level in relation to clinicopathological factors and prognoses of esophageal cancer (EC). MicroRNA was extracted using the Taqman(®) MicroRNA Assay from 46 EC patients at the same tumor node metastasis (TNM) stage, but with different prognoses, who underwent surgery. Paracancerous normal tissues were used as controls. The correlation between miR-197 expression and clinicopathologic features was analyzed, and the significance of miR-197 as a prognostic factor and its relationship with survival was determined. miR-197 expression was lower in patients with poor prognosis than in those with good prognosis (P < 0.05). Kaplan-Meier analysis results showed that the miR-197 expression level is significantly correlated with survival time (P = 0.030), and that patients with higher expression of miR-197 had longer survival times. Cox multi-factor model analysis showed that patient prognosis (P = 0.001), tumor length (P = 0.010) and expression (P = 0.042), and survival time were significantly correlated, with corresponding risks of 9.183, 2.318, and 1.925, respectively. This study supports a role of miR-197 as an anti-oncogene and a biomarker for EC and its relationship with other prognostic factors and survival.
IcsA autotransporter passenger promotes increased fusion protein expression on the cell surface (2012)

The export mechanism of autotransporters is not well understood but accumulating evidence suggest a critical role for the native effector or α domain in facilitating its own export via interactions with the translocation or β domain. This is the first report directly comparing expression of heterologous proteins fused to the full length IcsA autotransporter and fusion to the β domain alone. Protein expression and surface presentation of the fusion proteins were dramatically improved when fused to IcsA rather than IcsAβ. Future studies involved in designing autotransporters as cell surface display vehicles would benefit from including the native α domain. This work also provides further evidence for a key interaction between the autotransporter α and β domains.
Probing the Relationship between Silicalite-1 Defects and Polyol Adsorption Properties (2013)

The relationship between polyol adsorption affinity and silanol defect density was investigated through the development of vapor and aqueous adsorption isotherms on silicalite-1 materials which vary in structural and surface properties. Silicalite-1 crystals prepared through alkaline synthesis, alkaline synthesis with steaming post-treatment, and fluoride synthesis routes were confirmed as crystalline mordenite framework inverted (MFI) by SEM and XRD and were shown to contain ~8.5-0 silanol defects per unit cell by (29)Si MAS, (1)H MAS, and (1)H-(29)Si CPMAS NMR. A hysteresis in the Ar 87 K adsorption isotherm at 10(-3)P/P0 evolved with a decrease in silanol defects, and, through features in the XRD and (29)Si MAS NMR spectra, it is postulated that the hysteresis is the result of an orthorhombic-monoclinic symmetry shift with decreasing silanol defect density. Gravimetric and aqueous solution measurements reveal that propylene glycol adsorption at 333 K is promoted by silanol defects, with a maximum 20-fold increase observed for aqueous adsorption at ~10(-3) g/mL with an increase from ~0 to 8.5 silanols per unit cell. A comparison of vapor and aqueous propylene glycol adsorption isotherms on defect-free silicalite-1 at 333 K, both of which exhibit the Type-V character, indicates that water enhances adsorption by a factor of ~2 in the Henry's Law regime. Henry's constants for aqueous C2-C4 polyol adsorption (concentrations below 0.004 g/mL) at 298 K are shown to have a linear dependence on the silanol defect density, demonstrating that these molecules preferentially adsorb at silanol defects at dilute concentrations. This systematic study of polyol adsorption on silicalite-1 materials highlights the critical role of defects on adsorption of hydrophilic molecules and clearly details the effects of coadsorption of water, which can guide the selection of zeolites for separation of biomass-derived oxygenates.
Optimizing the Performance of Virtual Machine Synchronization for Fault Tolerance (2010)

Hypervisor-based fault tolerance (HBFT), which synchronizes the state between the primary VM and the backup VM at a high frequency of tens to hundreds of milliseconds, is an emerging approach to sustaining mission-critical applications. Based on virtualization technology, HBFT provides an economic and transparent fault tolerant solution. However, the advantages currently come at the cost of substantial performance overhead during failure-free, especially for memory intensive applications. This paper presents an in-depth examination of HBFT and options to improve its performance. Based on the behavior of memory accesses among checkpointing epochs, we introduce two optimizations, read-fault reduction and write-fault prediction, for the memory tracking mechanism. These two optimizations improve the performance by 31 percent and 21 percent, respectively, for some applications. Then, we present software superpage which efficiently maps large memory regions between virtual machines (VM). Our optimization improves the performance of HBFT by a factor of 1.4 to 2.2 and achieves about 60 percent of that of the native VM.
Electrical activity of artificial ion channels incorporated into planar lipid bilayers (1997)

The ion transport ability in a planar lipid bilayer of a 21 amino acid peptide bearing six 21-crown-7 side chains is reported. The compound was designed to form an artificial ion channel by stacking the crown rings, when adopting an α-helical conformation in a bilayer membrane. All the derivatives of 1 exhibited membrane conductivity with the best results obtained with the unprotected analog 4. The latter showed typical single channel activity.
Microencapsulated citronella oil for mosquito repellent finishing of cotton textiles (2010)

Microcapsules containing citronella essential oil were prepared by complex coacervation and applied to cotton textiles in order to study the repellent efficacy of the obtained fabrics. Citronella released from treated textiles was indirectly monitored by the extractable content of its main components. Repellent activity was assessed by exposure of a human hand and arm covered with the treated textiles to Aedes aegypti mosquitoes. Fabrics treated with microencapsulated citronella presented a higher and longer lasting protection from insects compared to fabrics sprayed with an ethanol solution of the essential oil, assuring a repellent effect higher than 90% for three weeks. Complex coacervation is a simple, low cost, scalable and reproducible method of obtaining encapsulated essential oils for textile application. Repellent textiles were achieved by padding cotton fabrics with microcapsules slurries using a conventional pad-dry method. This methodology requires no additional investment for textile finishing industries, which is a desirable factor in developing countries.
Role-based access control: a multi-dimensional view (2002)

Recently there has been considerable interest in role-based access control (RBAC) as an alternative, and supplement, to the traditional discretionary and mandatory access controls (DAC and MAC) embodied in the Orange Book. The roots of RBAC can be traced back to the earliest access control systems. Roles have been used in a number of systems for segregating various aspects of security and system administration. Recent interest in RBAC has been motivated by the use of roles at the application level to control access to application data. This is an important innovation which offers the opportunity to realize benefits in securing an organization's information assets, similar to the benefits of employing databases instead of files as the data repository. A number of proposals for RBAC have been published in the literature, but there is no consensus on precisely what is meant by RBAC. This paper lays the groundwork for developing this consensus. In our view RBAC is a concept which has several dimensions, all of which may not be present in a given system or product. We envisage each dimension as being linearly ordered with respect to the sophistication of features provided. This leads us to the idea of a multi-dimension model for RBAC. Achieving agreement on what these dimensions are, and how the features in each dimension should be ordered, will take debate and time. Our contribution here is to lay out a vision on how to approach a common understanding of RBAC, and take a first cut at identifying the dimensions of RBAC. A major benefit of such a multidimensional RBAC would be to allow comparison of different products and assess their appropriateness for various system requirements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rapid Progression to Simian AIDS Can Be Accompanied by Selection of CD4-Independent gp120 Variants with Impaired Ability To Bind CD4 (2002)

Aspartate 368 on human immunodeficiency virus type 1 (HIV-1) gp120 forms multiple contacts with CD4; in mutagenesis studies, its replacement by asparagine and corresponding changes in simian immunodeficiency virus SIVmac (D385N) reduced binding with CD4. Nevertheless, simian immunodeficiency virus envelopes with D385N were prevalent in several studies. Extending these observations, we also found D385N to be dominant among env clones from two rhesus macaques that progressed rapidly to simian AIDS. These envelopes showed a CD4-independent phenotype as well as reduced affinity to CD4. Moreover, an adjacent change, G383R, which was frequently coselected with D385N, further decreased binding. An optical biosensor study demonstrated that the SIVmac239 gp120 bound to CD4 with kinetics similar to those of HIV-1. However, the gp120s with D385N and G383R showed a 40-fold reduction in affinity, with a drastic increase in dissociation rate, indicating an inherently unstable complex. This finding showed that rapid progression to simian AIDS may be accompanied by the selection of CD4-independent gp120 variants with impaired CD4 binding ability.
Lipase-catalyzed Enantioselective Acylation in a Halogen Free Ionic Liquid Solvent System (2003)

Abstract Lipase-catalyzed enantioselective transesterification was demonstrated using several types of imidazolium alkyl sulfate as a reaction medium. The desired optically pure acetate was successfully obtained under the conditions used, although reaction rate was inferior to that in imidazolium tetrafluoroborate.
S100A8 and S100A9: New Insights into Their Roles in Malignancy (2011)

Recent studies have highlighted key roles played by non-neoplastic host cells of the tumor microenvironment, and by secreted factors from tumor and host cells, in promoting malignancy. In this regard, damage-associated molecular pattern (DAMP) molecules such as S100A8 and S100A9, with well-known functions in inflammation, have been increasingly recognized not only as markers, but also as new candidates with important roles in modulating tumor growth and metastasis. This review focuses on our current understanding of the pro- and anti-tumorigenic functions of S100A8 and S100A9. Elucidating molecular pathways mediated by these proteins promises to provide potential novel targets for the development of cancer therapeutics and to establish valid biomarkers to identify early stages of tumor progression.
Boundary Lubrication of Steel. Blends of Acids, Esters and Soaps in Mineral Oils. (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBoundary Lubrication of Steel. Blends of Acids, Esters and Soaps in Mineral Oils.William DaveyCite this: Ind. Eng. Chem. 1950, 42, 9, 1837–1841Publication Date (Print):September 1, 1950Publication History Published online1 May 2002Published inissue 1 September 1950https://pubs.acs.org/doi/10.1021/ie50489a040https://doi.org/10.1021/ie50489a040research-articleACS PublicationsRequest reuse permissionsArticle Views92Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Development of Tailor‐Made Cytostatics Activable by Acid‐Catalyzed Hydrolysis for Selective Tumor Therapy (1990)

The diamidophosphate 1, which is hardly toxic at physiological pH (7.2), undergoes cleavage at pH 6.2 (the pH value found in tumor cells) to glucose, methanol, and a cytotoxic ketone (t½ = 15 h). The survival rate of tumor cells can thereby be decreased in vitro by a factor of 5×104.
Experimental Study Of Threshold Voltage Fluctuations Using An 8k MOSFET's Array (1993)

In this paper, we have focussed on the threshold voltage V,, fluctuations of 8k NMOSFET’s in a less than 0.8mm2 area, using a newly developed 256x32 transistor array with a 8bit binary counter. It is experimentally shown for the first time that the V,, fluctuations depend on the channel length and the gate oxide thickness. Furthermore, it is directly demonstrated that the V,, fluctuations correlate with the dopant number fluctuations of the channel region.
Aerogels and related porous materials (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAerogels and related porous materialsH. D. Gesser and P. C. GoswamiCite this: Chem. Rev. 1989, 89, 4, 765–788Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://pubs.acs.org/doi/10.1021/cr00094a003https://doi.org/10.1021/cr00094a003research-articleACS PublicationsRequest reuse permissionsArticle Views4455Altmetric-Citations486LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase (2016)

Onconase is a ribonuclease that presents both antitumor and antiviral properties linked to its ribonucleolytic activity and represents a new class of RNA-damaging drugs. It has reached clinical trials for the treatment of several cancers and human papilloma virus warts. Onconase targets different RNAs in the cell cytosol but Onconase-treated cells present features that are different from a simple arrest of protein synthesis. We have used microarray-derived transcriptional profiling to identify Onconase-regulated genes in two ovarian cancer cell lines (NCI/ADR-RES and OVCAR-8). RT-qPCR analyses have confirmed the microarray findings. We have identified a network of up-regulated genes implicated in different signaling pathways that may explain the cytotoxic effects exerted by Onconase. Among these genes, activating transcription factor 3 (ATF3) plays a central role in the key events triggered by Onconase in treated cancer cells that finally lead to apoptosis. This mechanism, mediated by ATF3, is cell-type independent. Up-regulation of ATF3 may also explain the antiviral properties of this ribonuclease because this factor is involved in halting viral genome replication, keeping virus latency or preventing viral oncogenesis. Finally, Onconase-regulated genes are different from those affected by nuclear-directed ribonucleases.
Flexible update propagation for weakly consistent replication (1997)

Bayou's anti-entropy protocol for update propagation between weakly consistent storage replicas is based on pair-wise communication, the propagation of write operations, and a set of ordering and closure.
Study of a Circular Disc Monopole Ultrawide-band Miniature Antenna (2008)

Study of a novel planar circular disc monopole ultrawide-band antenna fed by coaxial line is presented in this paper. The radiator, ground plane and the feeder equipment of the antenna are placed on the same plate. The special structure reduces the spatial volume, and it is used to realize the miniaturization of the antenna. The basic theory and design method are analyzed, and detailed exploration is conducted to determine the antenna's properties. The current distributions, return loss, radiation patterns and gain of the antenna are discussed. In addition, the time domain performance of the proposed antenna is also evaluated in simulations. The research results show that this kind of planar antenna can radiate and receive short pulse signals without distortion. The 10dB return loss bandwidth is from 2.5GHz to 55GHz. And it can realize near omnidirectional pattern in the H-plane. It is a real planar structure and can really reduce the spatial volume. On this basis, the structure of the planar circular disc monopole antenna is improved. The radiator moves around the upper edge of the ground plane. The new structure reduces the antenna height to a certain degree and it is used to achieve further miniaturization. Analyses are conducted to determine the novel antennas' properties. The result of study indicates that the improved antenna can realize good bandwidth performance as the planar circular disc monopole antenna, and it has low-cost, simple structural characteristics. The novel miniature antenna and the improved type are suitable for the wireless communications, satellite communications and mobile communications systems with good prospects.
Migration of Double Bonds in Olefinic and Diolefinic Hydrocarbons Catalyzed by Sodium. Dehydrogenation of d-Limonene to p-Cymene<sup>2</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMigration of Double Bonds in Olefinic and Diolefinic Hydrocarbons Catalyzed by Sodium. Dehydrogenation of d-Limonene to p-Cymene2Herman Pines, J. A. Vesely, and V. N. IpatieffCite this: J. Am. Chem. Soc. 1955, 77, 2, 347–348Publication Date (Print):January 1, 1955Publication History Published online1 May 2002Published inissue 1 January 1955https://doi.org/10.1021/ja01607a031Request reuse permissionsArticle Views212Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (262 KB) Get e-Alertsclose Get e-Alerts
Development of Novel Galactosylated PLGA Nanoparticles for Hepatocyte Targeting Using Molecular Modelling (2020)

Doxorubicin-loaded PLGA nanoparticles conjugated with a new galactose-based ligand for the specific recognition by human hepatoma cellular carcinoma cells (Hep G2) were successfully produced. The new targeting compound was selected using molecular docking combined with quantum chemical calculations for modelling and comparing molecular interactions among the H1 subunit of the asialoglycoprotein receptor containing the carbohydrate recognition domain and the ligand. The ligand, bis(1-<i>O</i>-ethyl-β-D-galactopyranosyl)amine, was synthetized, characterized, and subsequently linked to PLGA. Unloaded (PLGA-di-GAL NP) and doxorubicin-loaded (DOX-PLGA-di-GAL NP) nanoparticles were prepared using an emulsion method and characterized. The produced DOX-PLGA-di-GAL NP are spherical in shape with a size of 258 ± 47 nm, a zeta potential of -62.3 mV, and a drug encapsulation efficiency of 83%. The in vitro drug release results obtained show a three-phase release profile. In vitro cell studies confirmed the interaction between Hep G2 cells and PLGA-di-GAL NP. Cell cytotoxicity tests showed that unloaded NP are nontoxic and that DOX-PLGA-di-GAL NP caused a decrease of around 80% in cellular viability. The strategy used in this work to design new targeting compounds represents a promising tool to develop effective hepatocyte targeting drug delivery systems and can be applied to other tissues/organs.
Design and fabrication of a MEMS micromirror with integrated charge sensor for feedback control (2004)

The "snap-through" or "pull-in" phenomenon limits the operating region of an electrostatic MEMS device controlled using a constant bias voltage to only one third of its physical deflection range. It has been shown that by controlling the charge on the actuator any static deflection inside the full gap range can theoretically be stabilized [18, 21, 22, 23]. Some existing approaches to this problem use passive charge feedback, implemented, for example, through a series capacitor. Others use open-loop charge control, involving the application of charge to a fixed capacitor, and the transfer of that charge to the MEMS. Electrostatically-actuated MEMS structures are fabricated at Texas Tech University using surface micromachining methods. The devices are intended to test voltage control laws now under development. The test structure includes the auxiliary electrode located directly on top of the lower drive electrode, to establish an integrated capacitor in order to make the desired charge measurement. This thesis concentrates on the manufacturability of such a device. Several fabrication processes were developed specifically for the previously mentioned devices. These processes include an isotropic plasma etch for deep undercut of MEMS structures, a low stress metal deposition process, and a photoresist profile modification procedure to ensure conformal step coverage in an electron beam metal deposition system. The development of several mirror designs are discussed, leading to the successful fabrication of a MEMS micromirror with integrated charge sensing capabilities.