gebhart/patrepeval huggingface dataset:
Influence of the Postoperative State on the Intracellular Free Amino Acids in Human Muscle Tissue (1975)

Five patients were studied before and two to three days after major, uncomplicated abdominal operation. Muscle tissue was obtained by needle biopsy from m. quadriceps femoris after eight hours overnight fast. Plasma free amino acids were analyzed in simultaneously obtained samples. In the homogenized muscle samples the intracellular concentration of each amino acid (IC) was calculated by subtracting the free extracellular part from the total amount, assuming the plasma concentration to be equal to the concentration in the interstitial fluid. Their relationships have also been calculated (IC/EC gradient). The extra- and intracellular water distribution was estimated using a modified chloride method. In similarity to the findings in normal subjects the majority of the amino acids showed much higher concentration in intracellular water than in plasma. Preoperatively all amino acids examined in muscle biopsies were formed within normal limits. Postoperatively the total amount of free amino acids in plasma and muscle was decreased, and the amino acid profiles differed from those observed in normal subjects. In plasma, as compared with normal controls, the most significant changes were an increase in phenylalanine and tyrosine and a decrease in serine, proline, histidine and isoleucine. In muscle the greatest decrease occurred in the concentrations of glutamine, arginine and lysine followed by proline and glutamic acid. The increase in taurine, valine and phenylalanine were all highly significant and in serin, glycine, alanine and leucine significant, whereas tyrosine showed only a moderate rise. Compared with normal values there were marked increases in the gradient between intracellular and plasma concentrations which were highly significant for glycine and valine and significant for serine, alanine, isoleucine and leucine. The shift in the methionine gradient was somewhat less. We confirm that alterations in the muscle free amino acid pool are not reflected in the values found in plasma. Further work is required to explore the clinical significance of the observed variations in individual amino acids.
Synergistic induction of nuclear factor-κB by transforming growth factor-β and tumour necrosis factor-α is mediated by protein kinase A-dependent RelA acetylation (2008)

The TGF-beta (transforming growth factor-beta) pathway represents an important signalling pathway involved in regulating diverse biological processes, including cell proliferation, differentiation and inflammation. Despite the critical role for TGF-beta in inflammatory responses, its role in regulating NF-kappaB (nuclear factor-kappaB)-dependent inflammatory responses still remains unknown. In the present study we show that TGF-beta1 synergizes with proinflammatory cytokine TNF-alpha (tumour necrosis factor-alpha) to induce NF-kappaB activation and the resultant inflammatory response in vitro and in vivo. TGF-beta1 synergistically enhances TNF-alpha-induced NF-kappaB DNA binding activity via induction of RelA acetylation. Moreover, synergistic enhancement of TNF-alpha-induced RelA acetylation and DNA-binding activity by TGF-beta1 is mediated by PKA (protein kinase A). Thus the present study reveals a novel role for TGF-beta in inflammatory responses and provides new insight into the regulation of NF-kappaB by TGF-beta signalling.
Visualizing Low‐Level Point Mutations: Enzyme‐like Selectivity Offered by Nanoparticle Probes (2010)

Highly selective DNA probes prepared by functionalizing gold nanoparticles with nonionic morpholino oligos are described. The nanoparticle probes offer enzyme-like selectivity based simply on hybridization reactions, allowing visual detection of a perfectly matched target within a large excess (>1000-fold) of single-base-mismatched DNA. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Survey of Rapid Design Methodology of Small Agricultural Machinery (2010)

Modern design technology was not popularized in the domain of small agricultural machinery products so that product design method needs to be improved. The purpose and significance of rapid design methodology applied in small agricultural machinery product was described by analyzing the research of current design method. The key technology of rapid design such as CAD technology,knowledge reuse,information integration etc. is applied in product design so as to template-based rapid design method and the creation of the information platform are proposed. The research prospects of design methodology in regard to small agricultural machinery using knowledge engineering and artificial intelligence are discussed.
Gas permeation through DDR‐type zeolite membranes at high temperatures (2008)

Abstract DDR‐type zeolite membranes were prepared by the secondary growth method on porous α‐alumina disk, followed by on‐stream counter diffusion chemical vapor deposition modification to eliminate the intercrystalline micropores. Single gas permeation of He, H 2 , CO 2 , and CO through this zeolite membrane before and after CVD modification was measured in 25–500°C. Intracrystalline diffusivities for these four gases in DDR‐type zeolite were obtained from the permeation data above 300°C to examine the effects of the size and molecular weight of permeating gases on diffusion and permeation rate for this zeolite membrane. For the unmodified DDR‐type zeolite membrane with presence of a small amount intercrystalline micropores the diffusivity (or permeance) with a low activation energy depends on both the size and molecular weight of permeating gases. For the CVD‐modified DDR‐type zeolite membrane with intercrystalline micropores eliminated, the activation energy for diffusion and diffusivity increases with increasing molecular size of the permeating gases. © 2008 American Institute of Chemical Engineers AIChE J, 2008.
Exhibition Poster 1 (2018)

https://digitalcommons.otterbein.edu/bewell/1039/thumbnail.jpg
New coupled-cluster methods with singles, doubles, and noniterative triples for high accuracy calculations of excited electronic states (2004)

The single-reference ab initio methods for high accuracy calculations of potential energy surfaces (PESs) of excited electronic states, termed the completely renormalized equation-of-motion coupled-cluster approaches with singles, doubles, and noniterative triples [CR-EOMCCSD(T)], are developed. In the CR-EOMCCSD(T) methods, which are based on the formalism of the method of moments of coupled-cluster equations, the suitably designed corrections due to triple excitations are added, in a state-selective manner, to the excited-state energies obtained in the standard equation-of-motion coupled-cluster calculations with singles and doubles (EOMCCSD). It is demonstrated that the CR-EOMCCSD(T) approaches, which can be regarded as the excited-state analogs of the ground-state CR-CCSD(T) theory, provide a highly accurate description of excited states dominated by double excitations, excited states displaying a manifestly multireference character, and PESs of excited states along bond breaking coordinates with the ease of the ground-state CCSD(T) or CR-CCSD(T) calculations. The performance of the CR-EOMCCSD(T) methods is illustrated by the results of calculations for the excited states of CH+, HF, N2, C2, and ozone.
Effects of Local Immunization with Glucosyltransferase Fractions from Streptococcus Mutans on Dental Caries in Rats and Hamsters (1977)

The effect of local immunization with glucosyltransferase enzymes of Streptococcus mutans on dental caries in conventional rats, hamsters, and gnotobiotic rats was studied. Injection of these animals with crude or defined glucosyltransferase enzyme preparations incorporated into complete Freund's adjuvant consistently resulted in the presence of antibody in saliva demonstrable by functional inhibition of enzymatic activity and binding of radioactive enzyme. Serum antibody was also present. Two experiments have been completed in conventional rats and one in gnotobiotic rats in which the animals were immunized with crude enzyme antigens. The immunized groups of animals always had lower mean caries scores than comparably sham-immunized or nonimmunized control groups. Hamsters immunized with a defined enzyme preparation, containing no more than three antigenic components (two of which were enzyme), also demonstrated significant reductions in mean caries scores. The numbers of lesions were also always lower in immunized animals. In some cases there were reductions in the numbers of S. mutans that could be recovered from the teeth of immunized, infected animals. The reductions in dental caries and lesions were greater on smooth dental surfaces than on occlusal surfaces, which might be explained as interference with adherence phenomena demonstrated by S. mutans. It is proposed that antibody interference affects dental caries caused by this organism.
Steady-state simulation of queueing processes: survey of problems and solutions (1990)

For years computer-based stochastic simulation has been a commonly used tool in the performance evaluation of various systems. Unfortunately, the results of simulation studies quite often have little credibility, since they are presented without regard to their random nature and the need for proper statistical analysis of simulation output data. This paper discusses the main factors that can affect the accuracy of stochastic simulations designed to give insight into the steady-state behavior of queuing processes. The problems of correctly starting and stopping such simulation experiments to obtain the required statistical accuracy of the results are addressed. In this survey of possible solutions, the emphasis is put on possible applications in the sequential analysis of output data, which adaptively decides about continuing a simulation experiment until the required accuracy of results is reached. A suitable solution for deciding upon the starting point of a steady-state analysis and two techniques for obtaining the final simulation results to a required level of accuracy are presented, together with pseudocode implementations.
Novel Kevlar-Walled Wind Tunnel for Aeroacoustic Testing of a Landing Gear (2008)

which allowed aeroacoustic measurements to be carried out in the far field and in an environment with significantly less reflections. The model was a very faithful replica of the full-scale landing gear, designed to address the issues associated with low-fidelity models. A 63-element microphone phased array was used to locate the noise-source components of the landing gear from different streamwise positions, both in the near and far fields. The same landing-gear model was previously tested in the original hard-walled configuration of the tunnel with the same phased array mounted on the wall of the test section (i.e., near-field position). The new anechoic configuration of the Virginia Polytechnic Institute and State University wind tunnel offered a unique opportunity to directly compare data collected in hard-walled and semi-anechoic test sections, using the same landing-gear model and phased-array instrumentation. Through these tests, some of the limitations associated with testing in hard-walled wind tunnels were addressed. Nomenclature Cj = components of the steering vector d = distance from the array to the model f = frequency ffull-scale = full-scale frequency fmeasured = measured frequency k = wave number M = flow Mach number rj = distance traveled by an acoustic ray from the grid point with coordinates xn to array microphone j Rj = distance between the grid point with coordinates xn and array microphone j xn = coordinates of the grid point to which the array is being steered � = wavelength
Controlling Charge Separation and Recombination Rates in CdSe/ZnS Type I Core−Shell Quantum Dots by Shell Thicknesses (2010)

Type I core/shell quantum dots (QDs) have been shown to improve the stability and conversion efficiency of QD-sensitized solar cells compared to core only QDs. To understand how the shell thickness affects the solar cell performance, its effects on interfacial charge separation and recombination kinetics are investigated. These kinetics are measured in CdSe/ZnS type I core/shell QDs adsorbed with anthroquinone molecules (as electron acceptor) by time-resolved transient absorption spectroscopy. We show that the charge separation and recombination rates decrease exponentially with the shell thickness (d), k(d) = k(0)e(-βd), with exponential decay factors β of 0.35 ± 0.03 per Å and 0.91 ± 0.14 per Å, respectively. Model calculations show that these trends can be attributed to the exponential decrease of the 1S electron and hole densities at the QD surface with the shell thickness. The much steeper decrease in charge recombination rate results from a larger hole effective mass (than electron) in the ZnS shell. This finding suggests possible ways of optimizing the charge separation yield and lifetime by controlling the thickness and nature of the shell materials.
Fault-tolerant design of local ESS processors (1978)

The stored program control of Bell System Electronic Switching Systems (ESS) has been under development since 1953. During this period, the No. 1 ESS, the No. 2 ESS, and the No. 3 ESS have been developed and used extensively by Bell System operating companies to provide commercial telephone service. These systems serve all types of telephone offices: The large-capacity No. 1 ESS serves metropolitan offices, the medium-capacity No. 2 ESS was designed for suburban offices, and the No. 3 ESS can be found in many small rural offices. The fault tolerant design of ESS processors provides the same highly dependable telephone service established by the previous electro-mechanical systems. Pertinent processor architecture features used to achieve ESS reliablity objectives are discussed. A detailed discussion of the maintenance design of the 3A Processor is also included.
Petroleum Reservoir Connectivity Patterns Reconstruction Using Deep Convolutional Generative Adversarial Networks (2018)

In this paper, we propose a deep convolutional generative adversarial network model to reconstruct the petroleum reservoir connectivity patterns. In the petroleum exploration industry, the critical issue is determining the internal reservoir structure and connectivity, aiming to find a flow channel for placing the injection and the production wells. The state-of-the-art methods propose a combination of seismic inversion with multipoint geostatistics, which imposes connectivity patterns during the optimization. However, this approach has a high computational cost, no learning ability and do not provide a probability through the connection. Results show that our approach is able to learn the petroleum reservoir connectivity patterns from the data and reproduce them also in facies images obtained by the seismic inversion.
Dry Coal Feed System and Multi-Element Injector Test Plan (2006)

Pratt & Whitney Rocketdyne (PWR) has developed an innovative gasifier concept that uses rocket engine technology to significantly improve gasifier performance, life, and cost compared to current state-of-the-art systems. One key feature of the PWR concept is the use of an ultra-dense phase feed system to provide dry coal to the multi-element injector. This report describes the layout, test procedures, instrumentation and data acquisition requirements for an ultradense phase multi-element injector and feed system to be operated at the University of North Dakota Energy and Environmental Research Center (UNDEERC).
Evaluation of MRSA-Screen, a Simple Anti-PBP 2a Slide Latex Agglutination Kit, for Rapid Detection of Methicillin Resistance in <i>Staphylococcus aureus</i> (1999)

The MRSA-Screen test (Denka Seiken Co., Ltd., Tokyo, Japan), consisting of a slide latex agglutination kit that detects PBP 2a with a monoclonal antibody, was blindly compared to the oxacillin disk diffusion test, the oxacillin-salt agar screen, and PCR of the mecA gene for the detection of methicillin resistance in Staphylococcus aureus. A total of 120 methicillin-susceptible S. aureus (MSSA) and 80 methicillin-resistant S. aureus (MRSA) isolates, defined by the absence or presence of the mecA gene, respectively, were tested. The MRSA-Screen test, the oxacillin disk diffusion test, and the oxacillin-salt agar screening test showed sensitivities of 100, 61.3, and 82.5% and specificities of 99.2, 96.7, and 98.3%, respectively. We conclude that the MRSA-Screen is a very accurate, reliable, and fast test (15 min) for differentiation of MRSA from MSSA colonies on agar plates.
Carrion (2008)

35 Headless deer at milepost 55 something like a beaver at the bridge over Route 83 smashed meat and bone beyond recognition on the ramp to the frontage road to the mall, beyond there the plowed under, paved over fields— Beaver Ridge, Houston Farms, Woodland Acres— denuded and flat farmlands dreamt into grids of Fox Hills and Apple Valley, linked and speared by channeled clearcuts linking cities, linking states, roads—88, 101, 95 accumulate and stack like suburbs on the horizons, while raccoons lie blankly beside porcupines; labyrinthine mess of intestines, hair, eyes there Carrion Anthony Walton 36 Ecotone: reimagining place or not there, glowing reflected light every half mile Deer Park, Beaver Ridge, Forest Glen, Indian Ridge ...
Principle of the New ATT‐Process for Converting Vegetable Oils to Diesel Fuels (1988)

Abstract Because of the worldwide current strongly rising oil and fat production rates there are needed already in the near future new and easy to handle application possibilities for large throughputs of oils and fats. One of these is their use as diesel fuel alternatives in the form of their methylesters. For European conditions methylesters on rapeseed oil basis are in this case of special interest not only because of the high production rate of this oil but also because of thier special physical conditions as liquid of low melting point and high heat content. On this reason we developed the new ATT‐process which is a complete semi‐continuous acting production line not only for converting natural oils via transesterification into methylesters including their purification but also for recovering all byproducts like glycerine, fatty acids and methanol as chemical pure compounds. Our unit consist out of six effective working operation steps using our special developments patented to us. This ATT‐process is opening good chances for integrating in the future our today suffering farm industry into modern industrial developments.
Characterization of the Humoral Immune Response Induced after Infection with Atypical Porcine Pestivirus (APPV) (2019)

Atypical porcine pestivirus (APPV) is a widely distributed pathogen causing congenital tremor (CT) in piglets. So far, no data are available regarding the humoral immune response against APPV. In this study, piglets and their sows from an affected herd were tested longitudinally for viral genome and antibodies. APPV genome was detected in the majority of the piglets (14/15) from CT affected litters. Transient infection of gilts was observed. Kinetics of E<sup>rns</sup>- and E2-specific antibodies and their neutralizing capacity were determined by recently (E<sup>rns</sup>) and newly (E2) developed antibody ELISAs and virus neutralization assays. Putative maternally derived antibodies (MDA) were detected in most piglets, but displayed only low to moderate neutralizing capacity (ND<sub>50</sub> ≤ 112). Horizontal APPV transmission occurred when uninfected and infected piglets were mingled on the flat deck. Horizontally infected piglets were clinically inapparent and showed only transient viremia with subsequently consistently high E2 antibody levels. For piglets from CT affected litters, significantly lower neutralizing antibody titers were observed. Results indicate that E2 represents the main target of neutralizing antibodies. Characterization of the humoral immune response against APPV will help to provide valuable serological diagnosis, to understand the epidemiology of this novel pathogen, and to implement tailored prevention strategies.
Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity (2015)

The ubiquitin-proteasome system (UPS) is the primary mechanism by which intracellular proteins, transcription factors, and many proteotoxic proteins with aggregation-prone structures are degraded. The UPS is reportedly downregulated in various neurodegenerative disorders, with increased proteasome activity shown to be beneficial in many related disease models. Proteasomes function under tonic inhibitory conditions, possibly via the ubiquitin chain-trimming function of USP14, a proteasome-associated deubiquitinating enzyme (DUB). We identified three specific RNA aptamers of USP14 (USP14-1, USP14-2, and USP14-3) that inhibited its deubiquitinating activity. The nucleotide sequences of these non-cytotoxic USP14 aptamers contained conserved GGAGG motifs, with G-rich regions upstream, and similar secondary structures. They efficiently elevated proteasomal activity, as determined by the increased degradation of small fluorogenic peptide substrates and physiological polyubiquitinated Sic1 proteins. Additionally, proteasomal degradation of tau proteins was facilitated in the presence of the UPS14 aptamers in vitro. Our results indicate that these novel inhibitory UPS14 aptamers can be used to enhance proteasome activity, and to facilitate the degradation of proteotoxic proteins, thereby protecting cells from various neurodegenerative stressors.
Altered expression of tumor suppressors p16 and Rb in gastric carcinogenesis (1997)

Abnormal expression of p16 and Rb may play an important role in gastric carcinogenesis.
Smoke and Mirrors (2008)

An electroacoustic composition (duration 20'30) realised in 16 discrete audio channels (48kHz/24 bit). The work was created in 2008 and given some minor revisions in 2010.
Quantitative Immunocapture PCR Assay for Detection of <i>Campylobacter jejuni</i> in Foods (2000)

The rapid detection of food-borne bacterial pathogens as part of a quality control program is necessary for the maintenance of a safe food supply. In this report, we present our findings for an immunocapture PCR method for the detection of Campylobacter jejuni in foods. The method permits direct detection of the pathogen without an enrichment step and can be performed in approximately 8 h. Assay results are quantitative, and one cell in a milliliter sample can be detected. Application of the method to spiked milk samples and chicken skin washes did not affect the sensitivity of the assay.
D cyclins in lymphocytes (2004)

These findings demonstrate that lymphocytes express cyclin D1 and necessitate a reappraisal of the hypothesis that the D cyclins subsume redundant activities with tissue-specific expression.