gebhart/patrepeval huggingface dataset:
Geoacoustic Uncertainties From Viscoelastic Inversion of Seabed Reflection Data (2006)

This paper applies nonlinear Bayesian inversion to seabed reflection data to estimate viscoelastic parameters of the upper sediments. The inversion provides maximum a posteriori probability (MAP) parameter estimates with uncertainties quantified in terms of marginal probability distributions, variances, and credibility intervals; interparameter relationships are quantified by correlations and joint marginal distributions. The inversion is applied to high-resolution reflectivity data from two sites in the Strait of Sicily. One site is characterized by low-speed sediments, resulting in data with a well-defined angle of intromission; the second is characterized by high-speed sediments, resulting in a critical angle. Data uncertainties are quantified using several approaches, including maximum-likelihood (ML) estimation, treating uncertainties as nuisance parameters in the inversion, and analysis of experimental errors. Statistical tests are applied to the data residuals to validate the assumed uncertainty distributions. Excellent results (i.e., small uncertainties) are obtained for sediment compressional-wave speed, compressional attenuation, and density; shear parameters are less well determined although low shear-wave speeds are indicated. The Bayesian analysis provides a quantitative comparison of inversion results for the two sites in terms of the resolution of specific geoacoustic parameters, and indicates that the geoacoustic information content is significantly higher for intromission data
TOPOGRAPHIC AND SURFACE CHEMICAL ASPECTS OF THE ADHESION OF STRUCTURAL EPOXY RESINS TO PHOSPHORUS OXO ACID TREATED ALUMINUM ADHERENDS (1998)

Structural adhesive bonding offers several advantages over other types of joining. These include improved stress distribution and increased design flexibility. Adhesive bonding is important in aerospace, automotive, and packaging applications. However, the full potential of the technology has not been exploited because the understanding of the basic mechanisms of adhesion and adhesion failure is incomplete. This investigation elucidates the chemical and mechanical mechanisms responsible for durable adhesion of epoxy resins to phosphorus oxo acid treated aluminum alloys. By systematically altering the adherend surface chemistry, surface topography, and adhesive formulation, combined with accelerated testing, the chemical and mechanical factors that influence the properties of adhesively bonded aluminum are isolated and assessed. It is postulated that a combination of two factors determines the strength and environmental durability of epoxy-bonded aluminum. One is the formation of hydrolytically stable, primary bonds between the adhesive and the adherend, and the second is the hydrolytic stability of the surface oxide, which is always present on the surface of aluminum and aluminum alloys. These conditions can best be met by chemical pretreatment of the oxide surface, which renders
Purification of Hemoglobin by Ion Exchange Chromatography in Flow-Through Mode with PEG as an Escort (2004)

Development of hemoglobin-based blood substitutes requires production of highly purified hemoglobin. Process of hemoglobin purification by ion exchange chromatography in flow-through mode was researched and optimized. Three kinds of media including, QMA Spherosil LS (Biosepra, France) and Q Sepharose Big Beads (Amersham Bioscience, Sweden), and an anion exchange membrane column, Mustang Q (PALL, USA) were investigated and compared. Adding polyethylene glycol (PEG) as an escort in ion exchange chromatography improved the purity and recovery, and the recovery in the chromatography was increased from 75 to 95%. The mechanism of PEG effects on chromatography was discussed. The optimal chromatography step, in combination with hypotonic dilution hemolyzing and membrane separation, formed an integrated hemoglobin purification process. The total recovery in the process was 87.6%. The activity of hemoglobin was well preserved: P50 23.2 mmHg, and Hill coefficient 2.31. The product appeared as a single band in SDS-PAGE, and GF-HPLC showed only one peak. The purity of the prepared hemoglobin was more than 99.9%. The optimized process is time saving and suitable for large-scale preparation of hemoglobin to provide materials for further preparation of blood substitutes.
Organic Solid-State Lasers: Past and Future (1997)

Researchers around the world are seeking organic materials that can be made into practical and efficient lasers. In their Perspective, Dodabalapur et al. review the past history and future prospect ...
The Rheological Behavior of Suspensions of Ion-exchange Resin Particles (1966)

Abstract The flow properties of the suspensions of ion-exchange resin particles, the highly-crosslinked polyelectrolyte gel particles, were examined, especially in relation to their charged state. The steady viscosities and the dynamic viscoelasticities of these suspensions were measured, and the results were interpreted in terms of the dispersion state of the suspended particles. The flow system of the highly-charged particles, such as Na-form resin particles, exhibits a high viscoelasticity and is in a well-dispersed state. On the contrary, the flow system of the lower-charged particles, such as Ba-form particles, is not viscoelastic, but viscous and dilatant. This behavior may be attributed to the variation in the electrical double layers around the suspended particles.
Go on Jack 英雄也连轴转 (2009)

看《24小时》,最紧张的不是情节,生化、核武、暗杀,编剧把能想到的危机都说遍了,我们在这类美式大片中见到此类情节也见怪不怪了,孤胆英雄并拯救全人类的半仙人物基本上也是老美的思维定式,难得的是这部剧集里面的反恐战术体系,说悬乎吧,其实也不是完全离谱,说真实吧,也许在几十年后才能实现。
Raccoon poxvirus recombinants expressing the rabies virus nucleoprotein protect mice against lethal rabies virus infection (1991)

Raccoon poxvirus (RCN) recombinants expressing the rabies virus internal structural nucleoprotein (RCN-N) protected A/WySnJ mice against a lethal challenge with street rabies virus (SRV). Maximum survival was achieved following vaccination by tail scratch and footpad (FP) SRV challenge. RCN-N-vaccinated mice inoculated in the FP with SRV were resistant to infection for at least 54 weeks postvaccination. Protection was also elicited by RCN recombinants expressing the rabies virus glycoprotein (RCN-G). Vaccination with RCN-G evoked rabies virus neutralizing antibody. Rabies virus neutralizing antibody was not detected in RCN-N-vaccinated mice prior to or following SRV infection. Radioimmunoprecipitation assays showed that sera from RCN-N-vaccinated mice which survived SRV infection did not contain antibody to SRV structural protein G, M, or NS. The mechanism(s) of N-induced resistance appears to correlate with the failure of peripherally inoculated SRV to enter the central nervous system (CNS). Support for this correlation with resistance was documented by the observations that SRV-inoculated RCN-N-vaccinated mice did not develop clinical signs of CNS rabies virus infection, infectious SRV was not detected in the spinal cord or brain following FP challenge, and all RCN-N-vaccinated mice died following direct intracranial infection of the CNS with SRV. These results suggest that factors other than anti-G neutralizing antibody are important in resistance to rabies virus and that the N protein should be considered for incorporation with the G protein in recombinant vaccines.
The absorption, translocation and distribution of the herbicide glyphosate in maize expressing the CP-4 transgene (1999)

more glyphosate than the roots.In both plant types, glyphosate was localized in the meristems and young, Maize (Zea mays L. var.Bonnie) transformed with a actively growing leaves.Specific glyphosate activity gene encoding a 5-enolpyruvylshikimate 3-phosphate (the amount of glyphosate per unit dry weight of tissue) synthase with altered sensitivity showed over 100-fold in the major sinks of the transgenic declined towards greater resistance to the herbicide glyphosate (Nthe end of the treatment period but remained relatively [phosphonomethyl]glycine) in comparison with its nonconstant in the parental control.In conclusion, enhantransformed progenitor (parental control) at the thirdcing glyphosate resistance by genetic transformation leaf stage.Studies with [14C]-glyphosate at a dosage influenced the absorption, translocation and distribulethal to the parental control, but sublethal to the tion of this herbicide in whole plants.transgenic, revealed that a maximum of 45-65% of the applied dose was absorbed, with greater absorption Key words: Zea mays, glyphosate (N-[phosphonomethyl]occurring in transgenic plants.Translocation of glycine), transgenic, absorption, translocation, sourceglyphosate was closely related to its absorption (r sink.value 0.956) with approximately 15% more of the applied dose being mobilized in transgenic plants than the parental controls.Analysis of electronic autoradi-
High density magnetic recording on a mini flexible disk drive (1981)

Small flexible disk drives have developed in a few years from 48 TPI (tracks per inch) single density, 125 kbyte products to 96 TPI double density, two-sided drives with 1 megabyte of capacity. The trend is toward more tracks per inch, with the industry goal currently at 144 TPI. The paper describes the technology that has been developed to make 144 TPI possible. This paper will discuss the evolution of drive technology, and point out some of the areas that still need work in order for 144 TPI to become a reality.
Anesthetic Approach to High-Risk Patients and Prolonged Awake Craniotomy Using Dexmedetomidine and Scalp Block (2013)

Dexmedetomidine, with concurrent scalp block, is an effective and safe anesthetic approach for awake craniotomy. Dexmedetomidine facilitates the extension procedure complexity and duration in patients who might traditionally not be considered to be candidates for this procedure.
Shock compression of diamond crystal (1983)

Two shock wave experiments employing inclined mirrors have been carried out to determine the Hugoniot elastic limit (HEL), final shock state at 191 and 217 GPa, and the post‐shock state of diamond crystal, which is shock‐compressed along the intermediate direction between the <111> and <110> crystallographic axes. The HEL wave has a velocity of 19.9 ± 0.3 mm/µsec and an amplitude of 63 ± 28 GPa. An alternate interpretation of the inclined wedge mirror streak record suggests a ramp precursor wave and then another HEL value. The maximum post‐shock density achieved upon release from the ∼200 GPa shock state is ∼3.95 Mg/m³, which compares to the initial density 3.52 Mg/m³. This result suggests an elastic unloading effect or shock‐induced transition to a denser (possibly metallic) phase.
Designing user-centered Web applications in Web time (2001)

As designers struggle to develop Web applications "in Web time," they are under the added pressure of delivering usability. The author describes her company's successful transformation to user-driven processes for designing e-commerce applications. She also offers strategies for introducing human factors methods into a reluctant development organization.
Abolishing Myofibroblast Arrhythmogeneicity by Pharmacological Ablation of α-Smooth Muscle Actin Containing Stress Fibers (2011)

The results suggest that α-SMA containing stress fibers importantly contribute to myofibroblast arrhythmogeneicity. After ablation of this cytoskeletal component, cells lose their arrhythmic effects on cardiomyocytes, even if heterocellular electrotonic coupling is sustained. The findings identify α-SMA containing stress fibers as a potential future target of antiarrhythmic therapy in hearts undergoing structural remodeling.
LibGuides: Music: Music (2010)

This guide contains resources for music coursework at PJC. Resources related to the coursework in music at PJC.
Trichostatin A reduces hormone‐induced transcription of the <i>MMTV</i> promoter and has pleiotropic effects on its chromatin structure (2004)

The deacetylase inhibitor trichostatin A (TSA) has long been used to study the relationship between gene transcription and the acetylation status of chromatin. We have used Xenopus laevis oocytes to study the effects of TSA on glucocorticoid receptor (GR)-dependent transcription and we have related these effects to changes in the chromatin structure of a reporter mouse mammary tumor virus (MMTV) promoter. We show that TSA induces a low level of constitutive transcription. This correlates with a change of acetylation pattern and a more open chromatin structure over the MMTV chromatin, and with specific acetylation and remodeling events in the promoter region. Specifically, a repositioning of initially randomly positioned nucleosomes along the distal MMTV long terminal repeat is seen. This nucleosome rearrangement is similar to the translational nucleosome positioning that occurs upon hormone activation. We also note a reduced hormone response in the presence of TSA. TSA effects have for a long time been associated with transcriptional activation and chromatin opening through inhibition of the deacetylation of histones. However, our results and those of others show that TSA-induced changes in expression and chromatin structure can be quite different in different promoter contexts and, thus, the effects of TSA are more complex than previously believed.
Optically coherent image reconstruction in the presence of phase errors using advanced-prior models (2018)

Recently developed coherent-imaging algorithms using Model-Based Iterative Reconstruction (MBIR) are robust to noise, speckle, and phase errors. These MBIR algorithms produce useful images with less signal which allows imaging distances to be extended. So far, MBIR algorithms have only incorporated simple image models. Complex scenes, on the other hand, require more advanced image models. In this work, we develop an MBIR algorithm for image reconstruction in the presence of phase errors which incorporates advanced image models. The proposed algorithm enables optically-coherent imaging of complex scenes at extended ranges.
A programmable and adaptive framework for 5G Network Slicing (2019)

The dawn of 5G brings with it the promise of significantly higher throughput and much lower latency delivered with high reliability by a softwarized and highly programmable network. 5G is quite different from the earlier wireless generations due to the huge diversity in the use cases it is aimed to cater to, including not-yet-foreseen services and requirements from new deployment scenarios. All of this makes a strong case for Network Slicing which logically, and in some cases, also physically partitions the network into slices, with each slice catering to a set of use cases (e.g., a slice each for enhanced mobile broadband (eMBB), massive machine-type communications (mMTC), and ultra-reliable low-latency communications (URLLC)), tenants, subscriber classes, industry verticals or a combination of one or more of these. Present network slicing techniques do not present an approach that is modular and flexible, so they have limitations in fitting into many deployment scenarios and/or have interoperability constraints. We propose a highly modular and flexible architecture in which components are of plug-and-play nature. We also propose an iterative and multi-step resource allocation strategy to optimally allocate resources to meet the slice and consequently the service Service Level Agreements (SLAs)/Key Performance Indicators (KPIs). Our proposed architecture and resource allocation approach can be applied to almost any kind of practical deployment scenario.
In vitro bactericidal and in vivo therapeutic activities of a new rifamycin derivative, KRM-1648, against Mycobacterium tuberculosis (1996)

The in vitro and in vivo activities of a new rifamycin derivative, KRM-1648, against Mycobacterium tuberculosis H37Rv were compared with those of rifampin. Bactericidal activity was evaluated by using a silicone-coated slide culture method. The MBC of KRM-1648 was 0.15 to 0.3 microgram/ml for 24 h of exposure, while that of rifampin was > 160 microgram/ml under the same conditions. Against experimental murine tuberculosis, KRM-1648 exhibited significant therapeutic effects, in terms of prolonged survival times for mice compared with those with rifampin treatment, even at lower doses, such as 1 and 3 mg/kg. At a dose of 3 mg/kg, KRM-1648 was at least as effective as rifampin at 10 mg/kg. The combination of KRM-1648 (3 mg/kg) plus isoniazid (3 mg/kg) plus ethambutol (10 mg/kg) exhibited much more activity than did rifampin (10 mg/kg) plus isoniazid (3 mg/kg) plus ethambutol (10 mg/kg). These findings suggest that KRM-1648 is a promising candidate for the treatment of tuberculosis.
Extending WPANs to Support Multi-Hop Communication with QoS Provisioning (2010)

Wireless personal area networks (WPANs) usually have very limited coverage. In this paper, we focus on methods to extend this range through multi-hop communication crossing several inter-connected WPANs called piconets. Multi-hop communication between piconets is possible through the bridge devices. While extending the range of WPANs, bridge devices become the capacity bottlenecks for these connected piconets. Therefore, an unoptimized resource allocation mechanism involving the bridges could degrade system performance severely. In this work we propose a novel resource allocation mechanism that outperforms other schemes proposed so far. Moreover, our scheme is QoS aware due to its cross-layer design. In our proposed scheme, resource allocation cooperates with the route discovery process to mitigate collisions due to inter-piconet resource reservations. Simulation results show that our approach significantly increases network capacity. This work is expected to pave the way for QoS support in WPANs.
Antisense Oligonucleotides Targeted against Protein Kinase Cβ and CβII Block 1,25-(OH)2D3-induced Differentiation (1998)

It is now recognized that protein kinase C (PKC) plays a critical role in 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) promotion of HL-60 cell differentiation. In this study, the effects of phosphorothioate antisense oligonucleotides directed against PKCalpha, PKCbeta, PKCbetaI, and PKCbetaII on HL-60 promyelocyte cell differentiation and proliferation were examined. Cellular differentiation was determined by nonspecific esterase activity, nitro blue tetrazolium reduction, and CD14 surface antigen expression. Differentiation promoted by 1,25-(OH)2D3 (20 nM for 48 h) was inhibited similarly in cells treated with PKCbeta antisense (30 microM) 24 h prior to or at the same time as hormone treatment (86 +/- 9% inhibition; n = 4 versus 82 +/- 8% inhibition; n = 4 (mean +/- S.E.), respectively). In contrast, cells treated with PKCbeta antisense 24 h after 1, 25-(OH)2D3 were unaffected and fully differentiated. PKCalpha antisense did not block 1,25-(OH)2D3 promotion of HL-60 cell differentiation. Next, the ability of PKCbetaI- and PKCbetaII-specific antisense oligonucleotides to block 1,25-(OH)2D3 promotion of cell differentiation was examined. PKCbetaII antisense (30 microM) completely blocked CD14 expression induced by 1, 25-(OH)2D3, whereas PKCbetaI antisense had little effect. Interestingly, PKCbetaII antisense blocked differentiation by 87 +/- 7% (n = 2, mean +/- S.D.) but had no effect on 1,25-(OH)2D3 inhibition of cellular proliferation. These results indicate that the effects of 1,25-(OH)2D3 on HL-60 cell differentiation and proliferation can be dissociated by blocking PKCbetaII expression.
Improving the start and restart behavior through state recognition of AC drives (2002)

The paper presents control strategies for abnormal operating conditions of AC motor drive systems. These improve the total performance as well as the ruggedness of the system. Two methods to start a rotating motor through state recognition are described. Two cases are distinguished according to whether the back EMF exists or not. In either case, normal operation can be reestablished as fast as possible on return of the power supply following a power interruption. Discussions and experimental results are presented for both failure conditions, based on V/f control and on sensorless field oriented control.
Glycogen Synthase Kinase-3β Facilitates IFN-γ-Induced STAT1 Activation by Regulating Src Homology-2 Domain-Containing Phosphatase 2 (2009)

Glycogen synthase kinase-3beta (GSK-3beta)-modulated IFN-gamma-induced inflammation has been reported; however, the mechanism that activates GSK-3beta and the effects of activation remain unclear. Inhibiting GSK-3beta decreased IFN-gamma-induced inflammation. IFN-gamma treatment rapidly activated GSK-3beta via neutral sphingomyelinase- and okadaic acid-sensitive phosphatase-regulated dephosphorylation at Ser(9), and proline-rich tyrosine kinase 2 (Pyk2)-regulated phosphorylation at Tyr(216). Pyk2 was activated through phosphatidylcholine-specific phospholipase C (PC-PLC)-, protein kinase C (PKC)-, and Src-regulated pathways. The activation of PC-PLC, Pyk2, and GSK-3beta was potentially regulated by IFN-gamma receptor 2-associated Jak2, but it was independent of IFN-gamma receptor 1. Furthermore, Jak2/PC-PLC/PKC/cytosolic phospholipase A(2) positively regulated neutral sphingomyelinase. Inhibiting GSK-3beta activated Src homology-2 domain-containing phosphatase 2 (SHP2), thereby preventing STAT1 activation in the late stage of IFN-gamma stimulation. All these results showed that activated GSK-3beta synergistically affected IFN-gamma-induced STAT1 activation by inhibiting SHP2.
Organic metals: synthesis and properties of bis-(1,3,-benzodithiole-2-ylidene)ethane [bi-(benzo-1,3-dithiafulven-6-yl)] (1983)

M. R. Bryce, J. Chem. Soc., Chem. Commun., 1983, 4 DOI: 10.1039/C39830000004
Hepatic Production of 1,5‐Anhydrofructose and 1,5‐Anhydroglucitol in Rat by the third Glycogenolytic Pathway (1996)

A unique anhydrohexulose, 1,5-anhydrofructose (1,5AnFru) has been detected in rat livers. Here we describe a microanalytical method for 1,5AnFru using GC/MS and report results on the distribution and production of 1,5 AnFru in rats. The highest levels of 1,5AnFru were found in the liver (0.43 microgram/g wet tissue) and appreciable amounts were detected in adrenal gland and spleen (0.12 microgram/g and 0.09 microgram/g, respectively). Other organs contained lower amounts while plasma contained virtually no detectable 1,5AnFru. We also demonstrated that 1,5AnFru is produced in the cytosol fraction of rat liver homogenate when an alpha-1,4-glucan or glycogen was added; 1,5AnFru was readily reduced to 1,5-anhydroglucitol with NADPH or at a reduced efficiency with NADH in the presence of a Mono Q chromatographic fraction obtained from the same cytosol preparation. Based on these results, we propose the existence of a third degradation pathway, in addition to the phosphorolytic and hydrolytic reaction sequences, from glycogen to 1,5-anhydroglucitol via 1,5AnFru in mammals. However, the physiological significance of 1,5AnFru and this putative minor glycogenolytic pathway in mammals remains obscure.
Why we feel: the science of human emotions (1999)

Biopsychologist Victor Johnston explores the origins of human emotions. Drawing on computer science, neurobiology, and evolutionary psychology, he argues that emotions are not an accident of nature, but are instead the basis of learning and reasoning, and help us to adapt to a complex, rapidly changing environment. In the process, he offers a new view of reality - what we see, hear, smell and feel is not an accurate representation of the world around us; rather, our feelings are illusions, shaped by millions of years of evolution.