gebhart/patrepeval huggingface dataset:
Endogenous growth factor expression in T-47D, human breast cancer cells, associated with reduced sensitivity to antiproliferative effects of progestins and antiestrogens. (1989)

To determine the functional significance of the endogenous expression of the epidermal growth factor (EGF) and transforming growth factor-alpha genes in T-47D, human breast cancer cells, we have examined the effects of two types of antiproliferative agents, progestins and antiestrogens, on the expression of these growth factors and the effects of exogenous EGF on the antiproliferative action of these agents. Using Northern blot analysis, the regulation of expression of these two genes by the antiproliferative agents, tamoxifen and monohydroxytamoxifen, was examined. In T-47D cells the two antiestrogens did not affect the accumulation of EGF mRNA and decreased the accumulation of TGF alpha mRNA. As we have shown before, the progestin, medroxyprogesterone acetate, increased the level of both EGF mRNA and TGF alpha mRNA in this cell line. The regulation of expression of these endogenous growth factor genes was unrelated to the proliferative behavior of T-47D cells since both antiestrogens and progestins were antiproliferative under the conditions of the experiments. The variant cell line, T-47D-5, had no detectable EGF mRNA and contained about 1/10th the level of TGF alpha mRNA expressed by "wild type" T-47D cells. T-47D-5 cells were 2.5 times more sensitive to the antiproliferative effects of both progestins and antiestrogens when compared to the growth factor expressing T-47D cells. Exogenously added murine EGF was able to decrease slightly the sensitivity of both cell lines to the antiproliferative effects of both progestins and antiestrogens as well as increase the proliferation of T-47D but not T-47D-5 cells. These data suggest that endogenous expression of growth factors may be associated with decreased sensitivity of the cells to growth inhibitory agents.
Admission Hyperglycemia in Critically Ill Sepsis Patients: Association With Outcome and Host Response* (2016)

Admission hyperglycemia is associated with adverse outcome of sepsis irrespective of the presence or absence of preexisting diabetes by a mechanism unrelated to exaggerated inflammation or coagulation.
An anti-image interference quadrature IF architecture for satellite receivers (2014)

Since Global Navigation Satellite System(GNSS) signals span a wide range of frequency, wireless signals coming from other communication systems may be aliased and appear as image interference. In quadrature intermediate frequency(IF) receivers, image aliasing due to in-phase and quadrature(I/Q) channel mismatches is always a big problem. I/Q mismatches occur because of gain and phase imbalances between quadrature mixers and capacitor mismatches in analog-to-digital converters(ADC). As a result, the dynamic range and performance of a receiver are severely degraded. In this paper, several popular receiver architectures are summarized and the image aliasing problem is investigated in detail. Based on this analysis, a low-IF architecture is proposed for a single-chip solution and a novel and feasible anti-image algorithm is investigated. With this anti-image digital processing, the image reject ratio(IRR) can reach approximately above50 dB, which relaxes image rejection specific in front-end circuit designs and allows cheap and highly flexible analog front-end solutions. Simulation and experimental data show that the antiimage algorithm can work effectively, robustly, and steadily.
ChemInform Abstract: SYNTHESIS OF APULEIDIN, A FLAVONE FROM APULEIA LEIOCARPA (1975)

Abstract Durch eine modifizierte Baker‐Venkataraman‐Methode wird Apuleidin (IVb), ein Flavon aus Apuleia leiocarpa, synthetisiert.
The Development of a Geopolymer-Based Pill as an Engineered Solution to Lost Circulation (2013)

Abstract Lost circulation is a common and highly varied drilling challenge. Whole fluid loss can be the result of entry into a highly permeable zone, vugular formation, or natural or induced fracture. Losses are further impacted by variables such as engineering practices, wellbore conditions, type of fluid (drilling, completion, cement, etc.) and formation properties. A variety of materials and techniques have been developed to stop lost circulation and stabilize the wellbore. One of the more common fluid solutions is the use of a dedicated pill formulation. These technologies may be comprised of particulate and/or fibrous material that is completely inert, or may be a chemically reactive solution that is triggered to form a sealant throughout the thief zone. Historically, these pills have proven highly effective, but most function under a narrow set of conditions. Another technical limitation for the materials used as a pill treatment is lack of structural integrity (strength) and a reduced tolerance to higher temperatures. This paper presents a comprehensive summary of the development of a new type of chemically reactive pill based on aqueous alkali alumino silicate as the key component. The aqueous alumino silicate is a low molecular weight, low viscosity solution that is sometimes referred to as a "geopolymer". Set times can range from several minutes to several hours based on the type and concentration of setting agent. By controlling the type, size and quantity of particulate material in the chemically reactive pill formulation, properties such as density, temperature resistance, strength and flexibility can be regulated to suit a wide range of lost circulation challenges. Models were developed on factors affecting set times, as well as properties of the uncured and cured formulas. These results are utilized to design a lost circulation pill that could be easily pumped through a bottomhole assembly over a wide range of loss rates and downhole conditions. The alumino silicate pill can provide strength properties approaching those of cement with a corresponding tolerance of high downhole temperatures. The environmental characteristics of the system and the economics of its application are also presented.
Tumor-intrinsic oncogene pathways mediating immune avoidance (2015)

Immunotherapy is emerging as a major treatment for patients with cancer, predominantly via blocking immune inhibitory pathways and through adoptive T cell therapy. However, only a subset of patients shows clinical responses to these interventions. Emerging data indicates a correlation between clinical response and a pre-existing T cell-inflamed tumor microenvironment. Tumor-intrinsic β-catenin activation has been identified as mediating exclusion of T cells from the tumor microenvironment and other oncogene pathways are being explored similarly. Understanding the molecular mechanisms underlying immune avoidance should identify new therapeutic targets for expanding efficacy of immunotherapies.
Prognostic Value of Lymph Node Yield and Density in Head and Neck Malignancies (2018)

Objective Studies have suggested that the lymph node yield and lymph node density from selective or elective neck dissections are predictive of patient outcomes and may be used for patient counseling, treatment planning, or quality measurement. Our objective was to systematically review the literature and conduct a meta-analysis of studies that investigated the prognostic significance of lymph node yield and/or lymph node density after neck dissection for patients with head and neck cancer. Data Sources The Ovid/Medline, Ovid/Embase, and NLM PubMed databases were systematically searched on January 23, 2017, for articles published between January 1, 1946, and January 23, 2017. Review Methods We reviewed English-language original research that included survival analysis of patients undergoing neck dissection for a head and neck malignancy stratified by lymph node yield and/or lymph node density. Study data were extracted by 2 independent researchers (S.C. and M.O.). We utilized the DerSimonian and Laird random effects model to account for heterogeneity of studies. Results Our search yielded 350 nonduplicate articles, with 23 studies included in the final synthesis. Pooled results demonstrated that increased lymph node yield was associated with a significant improvement in survival (hazard ratio, 0.833; 95% CI, 0.790-0.879). Additionally, we found that increased lymph node density was associated with poorer survival (hazard ratio, 1.916; 95% CI, 1.637-2.241). Conclusions Increased nodal yield portends improved outcomes and may be a valuable quality indicator for neck dissections, while increased lymph node density is associated with diminished survival and may be used for postsurgical counseling and planning for adjuvant therapy.
Bronchiolitis obliterans in chronic graft-versus-host disease: analysis of risk factors and treatment outcomes (2003)

Bronchiolitis obliterans (BrOb), a late complication of bone marrow transplantation (BMT), is associated with chronic graft-versus-host disease (GVHD) and is frequently fatal. To identify the risk factors associated with BrOb, the factors affecting survival, treatment outcomes, and causes of death of patients with BrOb, we retrospectively analyzed 2859 BMT recipients. No cases of BrOb occurred among 1070 autologous BMT recipients. Among 1789 allogeneic BMT recipients, we identified 47 patients with BrOb. In multivariate analysis, older recipients or donors and acute GVHD were significantly associated with the development of BrOb. Among patients with BrOb, 5-year survival from the time of transplantation was only 10%, versus 40% among allogeneic BMT recipients without BrOb. The clinical course of BrOb had a significant effect on survival: 79% survived 5 years from the time of BrOb diagnosis if BrOb improved versus 13% if there was no improvement after the first-line therapy. Predictors of response included older donors and recipients, a previous diagnosis of chronic GVHD, and diagnosis of BrOb 6 months after transplantation; each of these significantly increased the likelihood of a favorable response to treatment. BrOb had high mortality rate of 55%, and pulmonary failure was the leading cause of death. More effective BrOb therapy is needed, especially for patients with unfavorable presentation.
Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability (2010)

The SMEDDS can significantly increase curcumin dissolution in vitro and bioavailability in vivo.
Anaphylaxis to scorpion antivenin and its management following envenomation by Indian red scorpion, <i>Mesobuthus tamulus</i> (2015)

Mesobuthus tamulus is an Indian red scorpion that is responsible for numerous cases of scorpion stings in the Indian subcontinent. Antivenin, vasodilators, and benzodiazepines are medications of choice in the treatment of scorpion bites. Adverse reactions such as anaphylaxis to antivenin have been infrequently described in the literature. We, herein, present a case of a 42-year-old man stung by Indian red scorpion while gardening at home in India, who presented with extreme pain at the sting site and signs of cardio-toxicity. He was treated with scorpion antivenin and vasodilators but developed anaphylaxis to antivenin. We discuss management strategies. Anaphylaxis to antivenin should be on the differential during management of scorpion bites because classical signs of anaphylaxis may be absent.
Image Reconstruction on Color Sub‐Pixelated Displays (2008)

This chapter contains sections titled: The Opportunity of Biomimetic Imaging Systems Sub-pixel Image Reconstruction Defining the Limits of Performance: Nyquist, MTF and Moiré Limits Sub-pixel Rendering Algorithm Area Resample Filter Generation RGBW Color Theory RGBW Sub-pixel Rendering RGBW Sub-pixel Rendering Algorithm Gamma Correction and Quantization Error Reduction Conclusion References
Chemistry of oxaziridines. 9. Synthesis of 2-sulfonyl- and 2-sulfamyloxaziridines using potassium peroxymonosulfate (oxone) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of oxaziridines. 9. Synthesis of 2-sulfonyl- and 2-sulfamyloxaziridines using potassium peroxymonosulfate (oxone)Franklin A. Davis, Sankar Chattopadhyay, James C. Towson, Sankar Lal, and Thimma ReddyCite this: J. Org. Chem. 1988, 53, 9, 2087–2089Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/jo00244a043https://doi.org/10.1021/jo00244a043research-articleACS PublicationsRequest reuse permissionsArticle Views3806Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Colletotrichum – current status and future directions (2012)

A review is provided of the current state of understanding of Colletotrichum systematics, focusing on species-level data and the major clades. The taxonomic placement of the genus is discussed, and the evolution of our approach to species concepts and anamorph-teleomorph relationships is described. The application of multilocus technologies to phylogenetic analysis of Colletotrichum is reviewed, and selection of potential genes/loci for barcoding purposes is discussed. Host specificity and its relation to speciation and taxonomy is briefly addressed. A short review is presented of the current status of classification of the species clusters that are currently without comprehensive multilocus analyses, emphasising the orbiculare and destructivum aggregates. The future for Colletotrichum biology will be reliant on consensus classification and robust identification tools. In support of these goals, a Subcommission on Colletotrichum has been formed under the auspices of the International Commission on Taxonomy of Fungi, which will administer a carefully curated barcode database for sequence-based identification of species within the BioloMICS web environment.
Use of steam in oil production (1965)

For the first time, Shell Oil Co. speaks out on steam displacement. A summary of its views is as follows: (1) The steam soak is a stimulation or acceleration process, and therefore its applicability is limited to thick reservoirs having a relatively high percentage of oil based on rock volume and a satisfactory source of energy. A large fraction of the oil in place cannot be produced by this technique. (2) A considerable amount of empirical experience is being used by each operator to predict the production response. (3) Both the additional-oil/energy-input ratio and the cumulative additional oil need to be adequately know to predict the profitability of a project. The operator must have a thorough understanding of the applicable mechanism and exercise a high degree of control over engineering and operating function to be able to foresee and earn an adequate profit. (4) The steam-drive process holds promise for being a way of displacing a large amount of the oil in place. Any successful drive process which is developed will probably have a multiplicity of features unique to the particular reservoir under consideration.
Characterization of a Dimerization Motif in AP-2 and Its Function in Heterologous DNA-Binding Proteins (1991)

The mammalian transcription factor AP-2 is a retinoic acid inducible sequence-specific DNA-binding protein that is developmentally regulated. In this report, the functional domains necessary for AP-2 DNA binding were studied. AP-2 required a dimerization domain and an adjacent region of net basic charge to achieve a sequence-specific protein:DNA interaction. The sequences responsible for dimerization consisted of two putative amphipathic alpha helices separated by a large intervening span region. This helix-span-helix (HSH) domain was unable to bind DNA when separated from the basic region, but was still capable of dimerization. The ability of the HSH domain to function as a module that promotes DNA binding through dimerization was further demonstrated by attaching it to the heterologous basic region of the c-Jun proto-oncogene product. The resulting chimeric protein specifically recognized an AP-1 DNA-binding site in the absence of an intact c-Jun leucine repeat and in a manner that was dependent on the presence of a functional AP-2 dimerization domain.
Dual Feed RF Gun Design for the LCLS (2006)

In order to remove the dipole field introduced by the coupler in existing S-band BNL/SLAC/UCLA 1.6 cell RF gun, a dual feed design for the LCLS RF gun is proposed together with several significant changes. The improvements include adopting z-coupling instead of θ-coupling, modifying the iris dimensions and profile to increase 0-and π-mode separation from 3.4 to 15MHz and reduce the surface field on the iris, incorporating racetrack cavity shape to minimize the quadrupole field, increasing cooling for operation at 120Hz and other small changes to improve performance and diagnostic capabilities. The 3D gun structure had been modelled with the parallel finite element complex eigensolver Omega3p to provide the desired RF parameters and to generate the gun cavity dimensions needed for fabrication. In this paper the RF gun design will be presented
Biologie des déficits en complément (2000)

Le systeme du complement est un ensemble de proteines plasmatiques et de recepteurs cellulaires qui participe a la phase effectrice de la reponse immune specifique et aux mecanismes de defense naturelle de l’hote contre l’infection. Le systeme du complement comprend des proteines plasmatiques (composants et proteines regulatrices), des proteines membranaires de regulation et des recepteurs cellulaires pour certains composants ou leurs fragments d’activation. Trois voies d’activation, la voie classique, la voie des lectines et la voie alterne, aboutissent a la formation de complexes enzymatiques macromoleculaires (C3 convertases), capables de cliver le composant C3 ; ces trois voies se rejoignent au niveau de la voie finale commune pour former le complexe lytique C5b9 (figure 1) [1, 2]. En dehors de la fonction cytolytique, la plupart des effets biologiques du complement dependent de l’interaction des proteines du complement ou de leurs fragments d’activation avec des recepteurs cellulaires specifiques. Le systeme du complement a trois fonctions essentielles : la defense contre l’infection, le maintien en solution et l’elimination des complexes immuns, la participation a la regulation de la reponse immunitaire (tableau 1). En consequence, les deficits en proteines du complement sont associes a une frequence accrue de survenue d’infections bacteriennes et de maladies dites « a complexes immuns »
microPET imaging of urokinase-type plasminogen activator receptor expression using 64Cu-labeled cyclo19,31[D-Cys19]uPA19-31 (2007)

264 Objectives: Urokinse-type plasminogen activator (uPA) and its cell surface receptor (uPAR), central molecules of the major protease system responsible for ECM degradation, play important roles in tumor development, invasion and metastasis and represent potential targets for tumor intervention. To meet the demand of the rapid development and potential clinical application of anti-cancer therapy based on uPA/uPAR system, in this study we imaged uPAR expression with 64Cu labeled uPAR specific binding peptide. Methods: Taking advantage of the high affinity interaction between uPA and uPAR, we conjugated uPAR specific peptide— cyclo19,31[D-Cys19]uPA19-31 with macrocyclic chelating agent DOTA and labeled the conjugated peptide with 64Cu (t1/2 = 12.7 h). The tumor targeting efficacy and in vivo kinetics of the newly developed probe was studied in in two xenograft models (subcutaneous U87MG glioma and orthotopic MDA-MD-435 breast cancer) by microPET imaging. The uPAR expression of cell lines was confirmed by RT-PCR, western blot. Immunostaining was performed on both fixed cells and tumor sections. Results: The uPAR expression in U87MG cells was significantly higher than that in MDA-MB-435 cells at both mRNA and protein levels. Cell surface location of uPAR was confirmed by immunofluorescence staining. PET imaging revealed high tumor radioactivity accumulation (7.82 ± 0.60 %ID/g) at 17 hours postinjection (n=4) in uPAR positive U87MG xenograft tumor while no significant radioactivity accumulation was found in uPAR negative MDA-MB-435 tumors. The tracer excreted from both hepatic and renal routes. Conclusions: PET imaging with 64Cu-DOTA- cyclo19,31[D-Cys19]uPA19-31 could be used to monitor the location, magnitude and kinetics of uPAR expression in a real time and non-invasive manner. This approach will allow rapid translation into clinical settings for cancer detection, patients screening for uPA/uPAR system based therapy and monitoring the therapeutic efficacy.
Pluripotency Transcription Factor Oct4 Mediates Stepwise Nucleosome Demethylation and Depletion (2015)

The mechanisms whereby the crucial pluripotency transcription factor Oct4 regulates target gene expression are incompletely understood. Using an assay system based on partially differentiated embryonic stem cells, we show that Oct4 opposes the accumulation of local H3K9me2 and subsequent Dnmt3a-mediated DNA methylation. Upon binding DNA, Oct4 recruits the histone lysine demethylase Jmjd1c. Chromatin immunoprecipitation (ChIP) time course experiments identify a stepwise Oct4 mechanism involving Jmjd1c recruitment and H3K9me2 demethylation, transient FACT (facilitates chromatin transactions) complex recruitment, and nucleosome depletion. Genome-wide and targeted ChIP confirms binding of newly synthesized Oct4, together with Jmjd1c and FACT, to the Pou5f1 enhancer and a small number of other Oct4 targets, including the Nanog promoter. Histone demethylation is required for both FACT recruitment and H3 depletion. Jmjd1c is required to induce endogenous Oct4 expression and fully reprogram fibroblasts to pluripotency, indicating that the assay system identifies functional Oct4 cofactors. These findings indicate that Oct4 sequentially recruits activities that catalyze histone demethylation and depletion.
Precise eye detection on frontal view face image (2009)

The eye localization is a fundamental step in human-computer interaction and automatic face recognition. In this paper, a new eye detection method for face images is proposed. Firstly, the rough eye positions are found by Gabor transformation and cluster analysis. Secondly, a detection of pupil centers will be continued by applying two neighborhood operators in the rough eye regions. A subset of the color FERET database and the Faces 1999 database are used to evaluate the proposed method. Results of experiments show that our method is robust and efficient.