gebhart/patrepeval huggingface dataset:
A Systems Tester for Compact Homopolar Generator Component Development (1983)

To facilitate the development of more compact homopolar generators (HPGs), the compact HPG systems tester was designed and built to develop the system and component technology necessary to design HPGs having energy densities of up to 60 MJ/m 3 • The systems tester is one-half of a full-scale counter-rotating HPG storing 2.5 MJ at 6,900 rpm and generating 20 V. Incorporated in the tester are two new types of components, face brushes and a stationary-shaft hydrostatic bearing, which will lead to HPG designs that will rotate a larger fraction of of the magnetic circuit while eliminating much of the stationary support structure. The systems tester is designed to provide a facility for future bearing research and development of the higher-current- density brushgear required for drawing larger currents from the smaller slip ring areas of more compact machines.
Antigenicity, immunogenicity and passive protection induced by immunization of mice with baculovirus-expressed VP7 protein from rhesus rotavirus (1995)

The major neutralization antigen VP7 of rhesus rotavirus (RRV) was expressed in a baculovirus recombinant system. The expressed VP7 showed the same molecular mass as native VP7, and was recognized by hyperimmune sera as well as neutralizing and non-neutralizing monoclonal antibodies (MAbs) raised against RRV. Intraperitoneal administration of the expressed VP7 in mice elicited the production of serum antibodies which were able to immunoprecipitate VP7 from RRV-infected cell lysates and to neutralize the virus in vitro. Sera from immunized mice competed for binding to RRV in an ELISA with both neutralizing and non-neutralizing MAbs specific for VP7. Using a passive protection model of rotavirus disease, vaccination of mice with the recombinant VP7 induced partial protection from infection. These results suggest that the baculovirus-expressed VP7 may be useful in priming a protective immune response to rotavirus infection.
89 A Novel, Modified-Release Drug Delivery Technology Containing Amphetamine-Ion Exchange Complexes (2019)

Abstract The proprietary immediate and extended drug delivery technology LiquiXR™ utilizes an ion-exchange resin that complexes with amphetamine or any other active moiety that can be protonated and is water-soluble. The active drug product forms a complex with ion-exchange polymers contained in the resin, which is then formed into micron-sized particles. Some of these particles are coated with an aqueous, pH-independent polymer designed to provide immediate or sustained release of active drug product. The polymer coating applied to the ion-exchange resin particles is of varying thickness, allowing for programmed, extended release of active drug product. Solid, coating-free particles provide for immediate release of active drug product. The micron-sized particles are formulated into an appropriate dosage form (solid or chewable tablet, liquid suspension, orally disintegrating tablet, film, or capsules). Active drug product is subsequently released from the dosage form in millions of particles, with the release driven by a combination of ion exchange and diffusion. After drug release, the ion-exchange resin is excreted in the feces. The release characteristics of LiquiXR™ are programmable and allow for a customized, sustained release of active drug product for up to 24hours post-dose. Mechanistically, drug particles enter the gastrointestinal tract. As positively-charged ions from gastrointestinal (GI) fluids diffuse across the coating, ionically-charged drug product diffuses through the coating and into the GI fluids for absorption. As the coating is of variable thickness, some drug product takes longer to diffuse and absorb, providing for the programmable delayed drug release characteristic. The LiquiXR™ drug delivery technology is utilized in Dyanavel® XR (amphetamine extended-release oral suspension; AMPH EROS), which is indicated for the treatment of attention-deficit hyperactivity disorder. It comprises 2.5mg/mL amphetamine base complexed with LiquiXR technology to provide an immediate release component followed by an extended-release profile. The efficacy of AMPH EROS was established in children ages 6 to 12 years in a Phase 3, placebo-controlled laboratory classroom study. In that study, attention-deficit/hyperactivity disorder (ADHD) symptoms in children on an individually optimized dose of amphetamine (range 10–20mg/day) were statistically significantly improved compared with symptoms in children treated with placebo. For children treated with AMPH EROS, onset of effect was demonstrated at 1hour after dosing, and efficacy was observed through 13hours post-dose. The effect size was comparable to effect sizes demonstrated for other psychostimulants tested in studies using a similar design. The efficacy data reported for AMPH EROS provides an excellent example of the potential utility and clinical application for other active drug products requiring an immediate release and extended release profile. Funding Acknowledgements: This work was funded by Tris Pharma, Inc.
Semi-supervised Learning with GANs: Manifold Invariance with Improved Inference (2017)

Semi-supervised learning methods using Generative Adversarial Networks (GANs) have shown promising empirical success recently. Most of these methods use a shared discriminator/classifier which discriminates real examples from fake while also predicting the class label. Motivated by the ability of the GANs generator to capture the data manifold well, we propose to estimate the tangent space to the data manifold using GANs and employ it to inject invariances into the classifier. In the process, we propose enhancements over existing methods for learning the inverse mapping (i.e., the encoder) which greatly improves in terms of semantic similarity of the reconstructed sample with the input sample. We observe considerable empirical gains in semi-supervised learning over baselines, particularly in the cases when the number of labeled examples is low. We also provide insights into how fake examples influence the semi-supervised learning procedure.
GRP78 up‐regulation is associated with androgen receptor status, Hsp70–Hsp90 client proteins and castrate‐resistant prostate cancer (2010)

GRP78/BiP is a key member of the molecular chaperone heat shock protein (Hsp) 70 family. It has a critical role in prostate cancer (PC) including Pten loss-driven carcinogenesis, but the molecular basis of this remains unclear. We investigated the effect of GRP78 and its putative client proteins, including androgen receptor (AR) in clinical PC. Expression of GRP78 and key Hsp70-hsp90 client proteins (HER2, HER3, AR and AKT) were studied in an incidence tissue microarray (TMA) of prostate cancer. The relationship of GRP78 and AR was further tested in in vitro cell models (LNCaP and its derived LNCaP-CR subclone) and a matched TMA of hormone-naïve (HNPC) and castrate-resistant prostate cancer (CRPC). In vitro and in vivo expression of GRP78 and client proteins were assessed by western blotting and immunohistochemistry, respectively, using the weighted histoscore method. Significant co-expression of GRP78, pAKT, HER2, HER3 and AR was observed in PC. Abnormal AR, GRP78 and pAKT expression have significant impact on patient survival. GRP78 expression in AR(+) tumours was significantly higher than in AR(-) tumours. In keeping with our clinical data, activation of AR by dihydrotestosterone (DHT) potently activated GRP78 expression in both LNCaP and LNCaP-CR cells. For the first time, using a matched HNPC and CRPC TMA, enhanced cytoplasmic and membranous GRP78 expression was observed in CRPC. Future prospective studies are therefore warranted to validate GRP78 as prognostic marker and therapeutic target, in the context of the AR and pAKT status. In summary, GRP78 is co-expressed with Hsp70-hsp90 client proteins. Up-regulated expression of AR and GRP78 expression in untreated prostate cancer predicts a less favourable outcome. This points to the importance of understanding in the molecular interaction among AR, GRP78 and AKT.
Bone marrow transplantation following busulfan and cyclophosphamide for acute myelogenous leukemia. (1990)

Twenty-five consecutive patients with acute myelogenous leukemia (AML) underwent 26 allogeneic bone marrow transplants at Hahnemann University Hospital. Marrow ablation for all patients consisted of busulfan 16 mg/kg and cyclophosphamide 120 mg/kg (BUCY2). Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and methylprednisolone. Seventeen transplants were performed during first remission and the rest during subsequent remission or relapse. All patients engrafted and all but one achieved a complete remission (CR) following a short period of aplasia. Twenty-two of 25 patients are alive. All 17 patients with AML transplanted in first CR are alive and 15 of these patients are in sustained hematologic remission with an estimated 2-year disease free survival of 85%. The estimated 2-year disease free survival is 70% for all patients followed for a median of 622 days (range 134-1533). Acute GVHD of grades 2-4 occurred in 23% of these patients. Toxicities of the regimen including interstitial pneumonitis, veno-occlusive disease (VOD) and hemorrhagic cystitis were minimal. There were no treatment related deaths. These results demonstrate that BUCY2 should be considered as a preparative regimen for allogeneic bone marrow transplantation for patients with AML in first remission.
Methylene blue‐mediated photodynamic therapy: A possible alternative treatment for oral lichen planus (2006)

MB-PDT seems to be an effective alternative treatment for control of OLP. In our opinion, this preliminary result warrant further studies in order to show the efficacy of MB-PDT in control of OLP for a longer period of time.
Estimation of Salivary Glucose and Glycogen Content in Exfoliated Buccal Mucosal Cells of Patients with Type II Diabetes Mellitus (2015)

With the results of the present study it is revealed that salivary glucose and PAS positive cells are increased in diabetics which can be considered as adjuvant diagnostic tool for Diabetes mellitus.
Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications (2016)

A new drug-delivery system of polymer nanoparticles (NPs) bearing pinacol-type boronic ester and alkyne moieties displaying triggered self-immolative polymer degradation in the presence of reactive oxygen species (ROS) with the capability of cellular imaging is presented. The NPs specifically release their drug cargo under concentrations of ROS that are commonly found in the intracellular environment of certain tumors and of inflamed tissues and exhibit significant cytotoxicity to cancer cells compared to their non-ROS-responsive counterparts.
Shortened Ca <sup>2+</sup> Signaling Refractoriness Underlies Cellular Arrhythmogenesis in a Postinfarction Model of Sudden Cardiac Death (2012)

The attainment of a certain threshold [Ca(2+)](SR) is not sufficient for the generation of DCWs. Postrelease Ca(2+) signaling refractoriness critically influences the occurrence of DCWs. Shortened Ca(2+) signaling refractoriness due to RyR2 phosphorylation and oxidation is responsible for the increased rate of DCWs observed in VF myocytes and could provide a substrate for synchronization of arrhythmogenic events at the tissue level in hearts prone to VF.
Motion-Based Calibration of Multimodal Sensor Extrinsics and Timing Offset Estimation (2016)

This paper presents a system for calibrating the extrinsic parameters and timing offsets of an array of cameras, 3-D lidars, and global positioning system/inertial navigation system sensors, without the requirement of any markers or other calibration aids. The aim of the approach is to achieve calibration accuracies comparable with state-of-the-art methods, while requiring less initial information about the system being calibrated and thus being more suitable for use by end users. The method operates by utilizing the motion of the system being calibrated. By estimating the motion each individual sensor observes, an estimate of the extrinsic calibration of the sensors is obtained. Our approach extends standard techniques for motion-based calibration by incorporating estimates of the accuracy of each sensor's readings. This yields a probabilistic approach that calibrates all sensors simultaneously and facilitates the estimation of the uncertainty in the final calibration. In addition, we combine this motion-based approach with appearance information. This gives an approach that requires no initial calibration estimate and takes advantage of all available alignment information to provide an accurate and robust calibration for the system. The new framework is validated with datasets collected with different platforms and different sensors' configurations, and compared with state-of-the-art approaches.
Identification of Mycobacterium fortuitum and Mycobacterium chelonei (1983)

The study of 52 strains of rapidly growing mycobacteria showed that Mycobacterium fortuitum and M. chelonei were clearly distinguished by the aid of seven key tests (nitrate reductase, iron uptake, beta-glucosidase, penicillinase, growth on fructose, resistance to pipemidic acid, and resistance to capreomycin) and by analysis of their respective mycolic acids. However, the subdivision of these species into M. fortuitum var. fortuitum and M. fortuitum var. peregrinum and M. chelonei subsp. chelonei and M. chelonei subsp. abscessus was not satisfactorily accomplished.
Expected White Blood Cell Counts and Differentials in a Rat Model of Peritoneal Dialysis (1995)

This study of WBC counts and differentials in noninfected rats on peritoneal dialysis establishes the range above which infection should be suspected. WBC counts increase with cycle time. Small dialysate aliquots may underestimate WBC counts. Glucose concentration does not effect WBC counts.
Global stereo reconstruction under second order smoothness priors (2008)

Second-order priors on the smoothness of 3D surfaces are a better model of typical scenes than first-order priors. However, stereo reconstruction using global inference algorithms, such as graph-cuts, has not been able to incorporate second-order priors because the triple cliques needed to express them yield intractable (non-submodular) optimization problems. This paper shows that inference with triple cliques can be effectively optimized. Our optimization strategy is a development of recent extensions to a-expansion, based on the "QPBO" algorithm [5, 14, 26]. The strategy is to repeatedly merge proposal depth maps using a novel extension of QPBO. Proposal depth maps can come from any source, for example fronto-parallel planes as in a-expansion, or indeed any existing stereo algorithm, with arbitrary parameter settings. Experimental results demonstrate the usefulness of the second-order prior and the efficacy of our optimization framework. An implementation of our stereo framework is available online [34].
Analysis of repair mechanism choice during homologous recombination (2009)

Double-strand breaks (DSBs) occur frequently during cell growth. Due to the presence of repeated sequences in the genome, repair of a single DSB can result in gene conversion, translocation, deletion or tandem duplication depending on the mechanism and the sequence chosen as partner for the recombinational repair. Here, we study how yeast cells repair a single, inducible DSB when there are several potential donors to choose from, in the same chromosome and elsewhere in the genome. We systematically investigate the parameters that affect the choice of mechanism, as well as its genetic regulation. Our results indicate that intrachromosomal homologous sequences are always preferred as donors for repair. We demonstrate the occurrence of a novel tri-partite repair product that combines ectopic gene conversion and deletion. In addition, we show that increasing the distance between two repeated sequences enhances the dependence on Rad51 for colony formation after DSB repair. This is due to a role of Rad51 in the recovery from the checkpoint signal induced by the DSB. We suggest a model for the competition between the different homologous recombination pathways. Our model explains how different repair mechanisms are able to compensate for each other during DSB repair.
Electromagnetic Separation of Isotopes at Oak Ridge (1973)

In 1960 I attended a European conference on isotope separation, after which I visited the Niels Bohr Institute in Copenhagen. A staff member there ventured the opinion that the separation of isotopes will be first on the list of important contributions to the peaceful uses of the atom when the Atomic Energy Commission's memoirs are written in the year 2000. In 1968 the AEC Division of Research contracted with the National Research Council of the National Academy of Sciences to conduct a review of the AEC program for the separation of stable isotopes by electromagnetic and thermal diffusion methods. This ad hoc panel comprised seven scientists from the fields of chemistry, classical physics, geochemistry, geophysics, medicine, and physics. In their final report on national uses and needs for separated stable isotopes (9), they referred to the store of separated isotopes as a "real national asset that attains increasing value as science and technology develop" and recommended "continuation of the program as a national resource of great value to the United States." Later, in a discussion of this report with A. M. Weinberg, J. Koch, himself a pioneer in electromagnetic isotope separation and member of the Danish Atomic Energy Program, said he would correct the statement that the Oak Ridge electromagnetic facility is a "national asset" to read "international asset." From my narrow viewpoint after an extended and complete engrossment with this program for so many years, it is gratifying to learn that such men as those mentioned above share my belief that the work has indeed been worthwhile.
An Evaluation of SMT-Based Schedule Synthesis for Time-Triggered Multi-hop Networks (2010)

Networks for real-time systems have stringent end-to-end latency and jitter requirements. One cost-efficient way to meet these requirements is the time-triggered communication paradigm which plans the transmission points in time of the frames off-line. This plan prevents contentions of frames on the network and is called a time-triggered schedule (tt-schedule). In general the tt-scheduling is a bin-packing problem, known to be NP-complete, where the complexity is mostly driven by the freedom in topology of the network, its associated hardware restrictions, and application-imposed constraints. Multi-hop networks, in particular, require the synthesis of path-dependent tt-schedules to maintain full determinism of time-triggered communication from sender to receiver. Our experiments using the YICES SMT solver show that the scheduling problem can be solved by YICES out-of-the-box for a few hundred random frame instances on the network. A customized tt-scheduler using YICES as a back-end solver allows to increase this number of frame instances up to tens of thousands. In terms of scheduling quality, the synthesis produces up to ninety percent maximum utilization on a communication link with schedule synthesis times of about half an hour for the biggest examples we have studied. As a nice side-effect the YICES out-of-the-box approach is immediately applicable for the verification of existing (even large-scale) tt-schedules and for debugging more sophisticated tt-schedulers.
Potent Mimicry of Fibronectin-induced Intracellular Signaling in Glioma Cells by the Homodimeric Snake Venom Disintegrin Contortrostatin (2005)

Our results provide a mechanistic explanation of how soluble CN might block cellular migration and invasion, namely, by disrupting and preventing the binding of integrins to the extracellular matrix. We envision that this property of CN could be used in the treatment of gliomas, namely, by intratumoral infusion of CN to prevent glioma and endothelial cell interactions with the extracellular matrix, leading to inhibition of cell invasion.
ac electrokinetic micropumps: The effect of geometrical confinement, Faradaic current injection, and nonlinear surface capacitance (2006)

Recent experiments have demonstrated that ac electrokinetic micropumps permit integrable, local, and fast pumping (velocities approximately mm/s) with low driving voltage of a few volts only. However, they also displayed many quantitative and qualitative discrepancies with existing theories. We therefore extend the latter theories to account for three experimentally relevant effects: (i) vertical confinement of the pumping channel, (ii) Faradaic currents from electrochemical reactions at the electrodes, and (iii) nonlinear surface capacitance of the Debye layer. We report here that these effects indeed affect the pump performance in a way that we can rationalize by physical arguments.
Hohe Impulspermeabilität und hoher Induktionshub bei weichmagnetischen NiFe-Werkstoffen mit kristallographischer Textur und magnetisch induzierter Vorzugsrichtung (1979)

Article Hohe Impulspermeabilität und hoher Induktionshub bei weichmagnetischen NiFe-Werkstoffen mit kristallographischer Textur und magnetisch induzierter Vorzugsrichtung was published on March 1, 1979 in the journal International Journal of Materials Research (volume 70, issue 3).
Some properties of the NADP-specific malic enzyme from the moderate Halophile <i>Vibrio Costicola</i> (1980)

NADP-specific malic enzyme (EC 1.1.1.40) has been purified about 160-fold from the moderate halophile Vibrio costicola. The enzyme has a molecular weight of about 120,000. The purified enzyme was unstable in dilute solutions but could be stabilised by NaCl or glycerol. NH4Cl or KCI caused maximal activation at 0.1M, but higher concentrations were inhibitory. NaCl did not activate and was instead a mixed-type inhibitor towards NH4Cl or KCI. The salt concentration affected the kinetic parameters of the reaction. The apparent Km for L-malate reached a minimal value at about 0.1 M salt; the value for NADP, on the other hand, increased continuosly with the Co2+ or Mg2+. NADH was a mixed-type inhibitor towards both substrates, whereas oxaloacetate was strictly competitive towards L-malate and non-competitive towards NADP. The inhibition kinetics were sigmoidal for NADH and hyperbolic for oxaloacetate. The malic enzyme form V. costicola was similar to those of a marine Pseudomonas and Halobacterium cutirubrum in kinetic and regulatory properties but showed a response to salts intermediate between those of the latter enzymes.