gebhart/patrepeval huggingface dataset:
4D critical angle analysis using Valhall LoFS data (2010)

We propose to utilize long offset time‐lapse seismic as an alternative method to estimate small velocity changes when the background velocity is high. More specifically, we monitor the maximum amplitude offset that is beyond critical offset. The properties of the maximum amplitude offset is similar to critical offset, except that it appears for longer offsets and is frequency dependent. Increasing frequency reduces the gap between this offset and the critical offset. This study shows that the maximum amplitude offset is a function of overburden and reservoir velocity and is practically independent of density. This method requires a velocity increase (for monitor and base surveys) across the interface that is analyzed. Also, by long offset acquisition, we mean typically one to two kilometer beyond the critical offset. The method is tested on field data from the Valhall chalk field in the North Sea. The predicted velocity change using this method matches qualitatively the velocity changes predicted from an independent acoustic impedance study and the synthetic data reasonably well.
Association between the mammalian 110,000-dalton heat-shock protein and nucleoli. (1983)

A rabbit antiserum has been prepared using as antigen the 110,000-dalton mammalian heat-shock protein. This protein was purified for injection by two-dimensional PAGE of heat-shocked Chinese hamster ovary cells. Characterization by immunoautoradiography and immunoprecipitation reveals that the antiserum is specific for the 110,000-dalton protein. Both techniques also reveal that the protein against which the antiserum is directed is induced by heat shock. Indirect immunofluorescence shows that the antigen is primarily localized at or near the nucleolus in cultured cells and numerous murine tissues. Treatment of cultured cells with deoxyribonuclease destroys the organization of staining within the nucleus while ribonuclease appears to completely release the antigen from the nucleus. A binding of the antiserum to cytoplasmic structures is also observed by immunofluorescence. This association with nucleoli may have implications in the regulatory aspects of the heat-shock response.
tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers (2016)

tRNA-derived small RNA fragments (tRFs) are one class of small non-coding RNAs derived from transfer RNAs (tRNAs). tRFs play important roles in cellular processes and are involved in multiple cancers. High-throughput small RNA (sRNA) sequencing experiments can detect all the cellular expressed sRNAs, including tRFs. However, distinguishing genuine tRFs from RNA fragments generated by random degradation remains a major challenge. In this study, we developed an integrated web-based computing system, tRF2Cancer, to accurately identify tRFs from sRNA deep-sequencing data and evaluate their expression in multiple cancers. The binomial test was introduced to evaluate whether reads from a small RNA-seq data set represent tRFs or degraded fragments. A classification method was then used to annotate the types of tRFs based on their sites of origin in pre-tRNA or mature tRNA. We applied the pipeline to analyze 10 991 data sets from 32 types of cancers and identified thousands of expressed tRFs. A tool called 'tRFinCancer' was developed to facilitate the users to inspect the expression of tRFs across different types of cancers. Another tool called 'tRFBrowser' shows both the sites of origin and the distribution of chemical modification sites in tRFs on their source tRNA. The tRF2Cancer web server is available at http://rna.sysu.edu.cn/tRFfinder/.
A New Sesquiterpenoid Quinone and Other Related Compounds from the Okinawan Marine Sponge <i>Dactylospongia</i> <i>e</i><i>legans</i> (2002)

The new sesquiterpenoid quinone, neodactyloquinone (1), and dactylolactones A-D (2-5) were isolated from the Okinawan sponge Dactylospongia elegans. The structures of these compounds were determined by spectroscopic analysis.
A ± 0.75V opamp with rail-to-rail input/output range (1985)

An opamp with a minimum supply voltage of ±0.75V and a bandwidth of 0.6MHz using a nested loop frequency compensation technique will be reported. Dual input stages are used to allow common mode operation at either supply rail.
Use of gas concentration ratios to interpret LTC & OCB dissolved gas data (2004)

Dissolved gas analysis, DGA, has been universally accepted as the preeminent diagnostic tool for location of incipient faults in oil filled transformers. DGA has more recently been applied as a diagnostic tool for predictive maintenance on load tap changers, LTC's, and oil filled circuit breakers, OCB's. The savings in maintenance costs based on DGA diagnostics are significant. Data interpretation for OCB and LTC dissolved gas analysis is empirical in nature and significantly different than interpretation of DGA data for main tanks. Ratios of heating to arcing gases are informative for LTC and OCB dissolved gas analysis interpretation.
Plasmid electrotransfer of eye ciliary muscle: principles and therapeutic efficacy using hTNF‐α soluble receptor in uveitis (2005)

Due to its small size and particular isolating barriers, the eye is an ideal target for local therapy. Recombinant protein ocular delivery requires invasive and painful repeated injections. Alternatively, a transfected tissue might be used as a local producer of transgene-encoded therapeutic protein. We have developed a nondamaging electrically mediated plasmid delivery technique (electrotransfer) targeted to the ciliary muscle, which is used as a reservoir tissue for the long-lasting expression and secretion of therapeutic proteins. High and long-lasting reporter gene expression was observed, which was restricted to the ciliary muscle. Chimeric TNF-alpha soluble receptor (hTNFR-Is) electrotransfer led to elevated protein secretion in aqueous humor and to drastic inhibition of clinical and histological inflammation scores in rats with endotoxin-induced uveitis. No hTNFR-Is was detected in the serum, demonstrating the local delivery of proteins using this method. Plasmid electrotransfer to the ciliary muscle, as performed in this study, did not induce any ocular pathology or structural damage. Local and sustained therapeutic protein production through ciliary muscle electrotransfer is a promising alternative to repeated intraocular protein administration for a large number of inflammatory, degenerative, or angiogenic diseases.
Deblending by direct inversion (2012)

ABSTRACT Deblending of simultaneous-source data is usually considered to be an underdetermined inverse problem, which can be solved by an iterative procedure, assuming additional constraints like sparsity and coherency. By exploiting the fact that seismic data are spatially band-limited, deblending of densely sampled sources can be carried out as a direct inversion process without imposing these constraints. We applied the method with numerically modeled data and it suppressed the crosstalk well, when the blended data consisted of responses to adjacent, densely sampled sources.
K (1985)

Kanamycin Bactericidal aminoglycoside antibiotic with actions and spectrum similar to Neomycin, but less ototoxic.Used in gram-negative septicaemia, with monitoring of blood levels, particularly in renal failure.Potentiates neuromuscular blockade.Kaolin Adsorbent.Used externally as a dusting powder and by mouth as treatment for diarrhoea where it increases faecal bulk and slows passage through the gut.Once thought to have specific adsorbent effect for poisonous substances but it is now known that the adsorbent effect is a general one.Ketamine Parenteral anaesthetic with analgesic properties in subanaesthetic doses.Rapid onset of action, but may cause psychotic symptons, including hallucinations, the frequency of which can be reduced by giving Diazepam or Droperidol.Contraindicated in patients with high blood pressure or known psychosis.Ketazolam Benzodiazepine anxiolytic, with actions and adverse effects similar to Diazepam.Presently used to treat anxiety and muscle spasms.Ketoconazole Used to treat internal and external fungal infections.Adverse effects include nausea, rashes, and jaundice.Ketoprofen Anti-inflammatory/analgesic, with actions, uses and adverse effects similar to Ibuprofen.Ketotifen Preventative treatment for asthma.Has the actions of an antihistamine, similar to Promethazine and also blocks allergic mechanisms by a mechanism similar to Sodium cromoglycate.Adverse effects include dry mouth, dizziness, and sedation.56
Network-Based Business Process Analysis (2012)

This paper presents a quantitative approach to business process analysis using metrics from (social) network analysis. It is claimed that using this approach not only allows quantification of business process properties, but also provides insights on business process behavior that is not obvious from business process descriptions or models. The goal is to show that process characteristics can be explored and analyzed using network theory and methods of statistical analysis. The focus of this work is put on process type definition. To validate the approach business process model networks are evaluated against artificial networks with selected random graph distributions. The identified metrics are evaluated using a sample of real-life business processes.
Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells. (1997)

Oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione] is a synthetic dithiolethione with chemopreventive activity against carcinogen-induced neoplasia of liver, lung, and colon in several animal model systems. Protection from tumor formation is associated with elevation of Phase II enzymes, including glutathione (GSH) transferase and NAD(P)H:quinone oxidoreductase (DT-diaphorase) in experimental carcinogenesis models in vivo. To investigate the time and dose relationships of the pharmacological action of oltipraz and to develop a model for its investigation, a human colon adenocarcinoma HT29 cell line was primarily used. In this cell line, oltipraz resulted in increased activity of both GSH transferase and DT-diaphorase. At the maximum effective concentration (100 microM), the elevation of GSH transferase was 3-fold and that of DT-diaphorase was 2-fold. The optimal duration of oltipraz exposure to HT29 cells was 24 h, following which the peak in enzyme activity was observed at 24 h after removal of the drug, and activity had almost returned to control levels after 72 h in drug-free media. Steady-state mRNA levels for DT-diaphorase were observed to increase during the period of drug exposure and remained elevated, even as catalytic activities declined to control levels, suggesting additional mechanisms for control of the activity of this enzyme. More prolonged drug exposure was associated with less induction of the detoxication enzymes, prompting an investigation of the possible toxicity of oltipraz to these cells. Although the 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay revealed inhibition of proliferation (IC50, 100 microM oltipraz), a clonogenic assay demonstrated no loss of clonogenicity. Oltipraz is known to be extensively metabolized in many species; two major metabolites include a 3-ketone (metabolite 2, M2) and a molecular rearrangement to a pyrrolopyrazine derivative (metabolite 3, M3), numerous conjugates of which are formed in vivo. To investigate the potential cause of the lag in response, we synthesized two major oltipraz metabolites (M2 and M3) and tested their efficacy in enzyme induction. The activity of DT-diaphorase was induced similarly by both oltipraz and M2 (2.6- versus 2.8-fold baseline) at 100 microM, whereas M3 was inactive at all concentrations. M2 also resulted in a 5.8-fold elevation of steady-state DT-diaphorase mRNA levels. Both enzyme activity and steady-state mRNA peaked at 24 h as with the parent compound. Thus, the oxidative desulfuration of oltipraz results in the formation of an active metabolite, but this process is not rate limiting for the induction of detoxicating enzymes. These data support the use of intermittent schedules in oltipraz in clinical trials of chemoprevention because of evidence of attenuation of response. The metabolite M2, but not M3, is as active as the parent compound and may be considered for clinical development in its own right.
Association between hand-grip strength and depressive symptoms: Locomotive Syndrome and Health Outcomes in Aizu Cohort Study (LOHAS) (2015)

using a large population-based sample, our results suggest that lower hand-grip strength, standardised using age and gender, is both cross-sectionally and longitudinally associated with depressive symptoms.
Development of micropump‐actuated negative pressure pinched injection for parallel electrophoresis on array microfluidic chip (2009)

A micropump-actuated negative pressure pinched injection method is developed for parallel electrophoresis on a multi-channel LIF detection system. The system has a home-made device that could individually control 16-port solenoid valves and a high-voltage power supply. The laser beam is excitated and distributes to the array separation channels for detection. The hybrid Glass-PDMS microfluidic chip comprises two common reservoirs, four separation channels coupled to their respective pneumatic micropumps and two reference channels. Due to use of pressure as a driving force, the proposed method has no sample bias effect for separation. There is only one high-voltage supply needed for separation without relying on the number of channels, which is significant for high-throughput analysis, and the time for sample loading is shortened to 1 s. In addition, the integrated micropumps can provide the versatile interface for coupling with other function units to satisfy the complicated demands. The performance is verified by separation of DNA marker and Hepatitis B virus DNA samples. And this method is also expected to show the potential throughput for the DNA analysis in the field of disease diagnosis.
Temperature-sensitive transforming mutants of the v-rel oncogene (1993)

By making site-directed mutations in the avian retroviral oncogene v-rel, we created two temperature-sensitive (ts) transforming mutants; these changes were analogous to mutations previously shown to confer a ts function onto the Dorsal protein of Drosophila melanogaster. Chicken spleen cells infected with the ts v-rel mutants formed colonies in agar at 36.5 degrees C but not at 41.5 degrees C. In addition, spleen cells derived from the ts v-rel-transformed colonies could be propagated in liquid culture at 36.5 degrees C but rapidly senesced at 41.5 degrees C. Both mutant v-Rel proteins were also ts for DNA binding in vitro. These mutants may be valuable for identifying genes directly regulated by v-rel.
Parkinson's disease and megacolon (1987)

Concentric hyaline inclusions (Lewy bodies), found in the cytoplasm of pigmented and nonpigmented neurons, are considered characteristic of idiopathic Parkinson's disease. The finding of cytoplasmic inclusions identical to Lewy bodies in ganglion cells of the colonic myenteric plexus in a patient with idiopathic Parkinson's disease and acquired megacolon suggests primary involvement of the enteric nervous system by Parkinson's disease.
Time-Lapse Imaging of Human Heart Motion With Switched Array UWB Radar (2014)

Radar systems for detection of human heartbeats have mostly been single-channel systems with limited spatial resolution. In this paper, a radar system for ultra-wideband (UWB) imaging of the human heart is presented. To make the radar waves penetrate the human tissue the antenna is placed very close to the body. The antenna is an array with eight elements, and an antenna switch system connects the radar to the individual elements in sequence to form an image. Successive images are used to build up time-lapse movies of the beating heart. Measurements on a human test subject are presented and the heart motion is estimated at different locations inside the body. The movies show rhythmic motion consistent with the beating heart, and the location and shape of the reflections correspond well with the expected response form the heart wall. The spatial dependent heart motion is compared to ECG recordings, and it is confirmed that heartbeat modulations are seen in the radar data. This work shows that radar imaging of the human heart may provide valuable information on the mechanical movement of the heart.
Ubiquitin-Independent Proteasomal Degradation of Fra-1 Is Antagonized by Erk1/2 Pathway-Mediated Phosphorylation of a Unique C-Terminal Destabilizer (2007)

Fra-1, a transcription factor that is phylogenetically and functionally related to the proto-oncoprotein c-Fos, controls many essential cell functions. It is expressed in many cell types, albeit with differing kinetics and abundances. In cells reentering the cell cycle, Fra-1 expression is transiently stimulated albeit later than that of c-Fos and for a longer time. Moreover, Fra-1 overexpression is found in cancer cells displaying high Erk1/2 activity and has been linked to tumorigenesis. One crucial point of regulation of Fra-1 levels is controlled protein degradation, the mechanism of which remains poorly characterized. Here, we have combined genetic, pharmacological, and signaling studies to investigate this process in nontransformed cells and to elucidate how it is altered in cancer cells. We report that the intrinsic instability of Fra-1 depends on a single destabilizer contained within the C-terminal 30 to 40 amino acids. Two serines therein, S252 and S265, are phosphorylated by kinases of the Erk1/2 pathway, which compromises protein destruction upon both normal physiological induction and tumorigenic constitutive activation of this cascade. Our data also indicate that Fra-1, like c-Fos, belongs to a small group of proteins that may, under certain circumstances, undergo ubiquitin-independent degradation by the proteasome. Our work reveals both similitudes and differences between Fra-1 and c-Fos degradation mechanisms. In particular, the presence of a single destabilizer within Fra-1, instead of two that are differentially regulated in c-Fos, explains the much faster turnover of the latter when cells traverse the G(0)/G(1)-to-S-phase transition. Finally, our study offers further insights into the signaling-regulated expression of the other Fos family proteins.
Fairness and Convergence of CSMA with Enhanced Collision Avoidance (ECA) (2010)

This paper presents CSMA/ECA, which combines the efficiency of reservation-based protocols and the simplicity of random access mechanisms. The maximum efficiency of CSMA/CA with optimal parameter adjustment is easily exceeded by CSMA/ECA, even when fixed parameters are used by the latter. CSMA/ECA stations fairly coexist with legacy CSMA/CA and increase the portion of time that is devoted to successful transmissions while decreasing the number of collisions and empty slots. The proposed mechanism initially behaves as a CSMA/CA network, but it progressively converges to a collision-free deterministic operation. The convergence process can be modelled as a Markov Chain to assess the duration of the transitory phase.
The membrane-associated component of the amphiphile-activated, cytosol-dependent superoxide-forming NADPH oxidase of macrophages is identical to cytochrome b559. (1991)

The superoxide (O2-) forming NADPH oxidase complex of resting phagocytes can be activated in a cell-free system by certain anionic amphiphiles, such as sodium dodecyl sulfate (SDS). For O2- production to occur, the participation of both membrane-associated and cytosol-derived components is required. The purpose of this investigation was to isolate and characterize the membrane component of NADPH oxidase. For this purpose, guinea pig macrophage membranes were extracted with 1 M NaCl, solubilized by 40 mM octyl glucoside, and subjected to a purification sequence consisting of absorption with DEAE-Sepharose, affinity chromatography on heparin-agarose, and chromatography on hydroxylapatite. At each purification step, fractions were assayed for their ability to support SDS-elicited, cytosol-dependent O2- production, following incorporation in liposomes of phosphatidylcholine. We found that membrane oxidase activity copurified strictly with cytochrome b559. Peak hydroxylapatite fractions exhibited specific O2(-)-forming activity in the range of 81-115 mumol of O2-/mg protein/min and a specific cytochrome b559 content of 7-14 nmol of cytochrome b559/mg protein. SDS-polyacrylamide gel electrophoresis analysis of the peak oxidase activity fractions, derived by hydroxylapatite chromatography, revealed essentially two bands that were identified as the beta (54-60 kDa) and alpha (21/22 kDa) subunits of guinea pig cytochrome b559. The relation of the two polypeptides to cytochrome b559 was established by correlation with a spectral signal characteristic of cytochrome b559, immunoblotting with antibodies against defined human cytochrome b559 beta and alpha chain peptides, cross-linking studies, and deglycosylation experiments. Hydroxylapatite-purified membrane oxidase preparations did not contain FAD and were free of cytochrome c reductase activity. Purified membrane oxidase preparations were also capable of cooperating with purified cytosolic components in SDS-elicited cell-free O2- production. We conclude that the membrane-associated component of the O2- generating NADPH oxidase is identical to cytochrome b559.
Two-Way Doherty Power Amplifier Efficiency Enhancement by Incorporating Transistors’ Nonlinear Phase Distortion (2018)

This letter starts with describing the efficiency of two-way Doherty power amplifier (DPA) in the presence of the nonlinear phase distortion of the constituent transistors. Combined with the proper choice of the complex-valued load impedance's reactance, this analysis directed the design of DPA with enhanced efficiency over extended output back-off power region and bandwidth. Results of measurement conducted using a proof-of-concept demonstrator designed to operate in the frequency band ranging from 1.35 to 1.7 GHz revealed average efficiency of 59%-62% under 20-MHz long-term evolution modulated signal.
ISSUES IN ROCK MECHANICS. PROCEEDINGS OF THE 23RD SYMPOSIUM ON ROCK MECHANICS, UNIVERSITY OF CALIFORNIA, BERKELEY, CALIFORNIA, AUGUST 25-27 1982 (1982)

For abstracts of some of the papers contained in the book see TRIS 452577 to 452613. (TRRL) symposium see TRIS 452576. (TRRL)
The design of broadband light modulators (1970)

Curve sets are presented for the design of collinear travelling-wave light modulators using KDP, KDA, ADP(r63), ADP(r41), LiNbO3, LiTaO, as electro-optic materials. The transverse dimensions ratio, the characteristic impedance and the bandwidth-length product are plotted versus the velocity mismatch. The attenuation of modulating signal is plotted versus mismatch for the peak voltage and modulating power for different lengths of the electro-optic materials. Examples of the use of these curves are reported.