gebhart/patrepeval huggingface dataset:
The Human Myt1 Kinase Preferentially Phosphorylates Cdc2 on Threonine 14 and Localizes to the Endoplasmic Reticulum and Golgi Complex (1997)

Entry into mitosis requires the activity of the Cdc2 kinase. Cdc2 associates with the B-type cyclins, and the Cdc2-cyclin B heterodimer is in turn regulated by phosphorylation. Phosphorylation of threonine 161 is required for the Cdc2-cyclin B complex to be catalytically active, whereas phosphorylation of threonine 14 and tyrosine 15 is inhibitory. Human kinases that catalyze the phosphorylation of threonine 161 and tyrosine 15 have been identified. Here we report the isolation of a novel human cDNA encoding a dual-specificity protein kinase (designated Myt1Hu) that preferentially phosphorylates Cdc2 on threonine 14 in a cyclin-dependent manner. Myt1Hu is 46% identical to Myt1Xe, a kinase recently characterized from Xenopus laevis. Myt1Hu localizes to the endoplasmic reticulum and Golgi complex in HeLa cells. A stretch of hydrophobic and uncharged amino acids located outside the catalytic domain of Myt1Hu is the likely membrane-targeting domain, as its deletion results in the localization of Myt1Hu primarily to the nucleus.
High Detectivity All‐Printed Organic Photodiodes (2015)

All-printed organic photodiode arrays on plastic are reported with average specific detectivities of 3.45 × 10(13) cm Hz(0.5) W(-1) at a bias of -5 V. The blade-coated polyethylenimine cathode interlayer and active layer, and screen-printed anode enable precise device performance tunability and excellent homogeneity at centimetric scales. These devices' high operational reverse bias, good linear dynamic range, and bias stress stability make them attractive for implementation in imaging systems.
A STANDARD FLUORESCENCE SPECTRUM FOR CALIBRATING SPECTRO-FLUOROPHOTOMETERS (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA STANDARD FLUORESCENCE SPECTRUM FOR CALIBRATING SPECTRO-FLUOROPHOTOMETERSW. H. MelhuishCite this: J. Phys. Chem. 1960, 64, 6, 762–764Publication Date (Print):June 1, 1960Publication History Published online1 May 2002Published inissue 1 June 1960https://pubs.acs.org/doi/10.1021/j100835a014https://doi.org/10.1021/j100835a014research-articleACS PublicationsRequest reuse permissionsArticle Views1113Altmetric-Citations196LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Design of flexible GF(2/sup m/) elliptic curve cryptography processors (2006)

The design of flexible elliptic curve cryptography processors (ECP) is considered in this paper. Novel word-level algorithms and implementations for the underlying GF(2/sup m/) multiplication and squaring arithmetic which enable improved flexibility versus performance tradeoffs, are presented and employed in the design of an efficient flexible ECP architecture; corresponding field-programmable gate-array (FPGA) prototyping results for two different processor word lengths are also included for evaluation.
Some Surprising Results about Covariate Adjustment in Logistic Regression Models (1991)

Laurence D. Robinson, Nicholas P. Jewell, Some Surprising Results about Covariate Adjustment in Logistic Regression Models, International Statistical Review / Revue Internationale de Statistique, Vol. 59, No. 2 (Aug., 1991), pp. 227-240
A closed-loop operation of super high-speed reluctance motor for quick torque response (1992)

The authors examine operating modes of the cageless reluctance motor and propose a new control method for quick torque response. It is shown that the control of sinusoidal phase current in magnitude with fixed current phase angle provides a simple means for achieving quick torque response and efficient operation. The flux linkage, current, torque. and the rated voltage of the inverter are calculated for a reluctance motor. A performance comparison is made between the proposed control method and the field-oriented control method. Analysis and computer simulation show that substantial improvements in dynamic response and efficiency are achieved for a reluctance motor when operated with constant current phase angle compared with operation at constant direct axis current or constant flux. Test data from a 24000 r/min. 1.3 kW reluctance motor drive system are provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Remote Temperature Sensing in Organic Tissue by Ferrimagnetic Resonance Frequency Measurements (1981)

A remote temperature sensing method is presented which uses the temparature dependence of the ferrimagnetic resonance frequency in iron garnet spheres. The garnet material parameters are discussed for optimizing the measuring sensitivity and the temperature resolution. An accuracy of 0.3°C in the range of 35 to 50°C has been achieved.
Expression of Foreign Genes in the yeast Pichia pastoris (2006)

ConclusionAlthough the P. pastoris expression system is not suitable for the production of all foreign proteins, many are compatible with the system. For these proteins, there are major advantages to production in this yeast. Relative to higher eukaryotic expression systems, culturing costs are lower, yields (foreign protein/L of culture medium) are usually higher, and for secreted proteins, the initial purity of the product in the culture medium is higher. Relative to bacterial expression systems, the chances of recovering a eukaryotic foreign protein in its biologically active form are significantly higher with P. pastoris. Although few major P. pastoris- produced human Pharmaceuticals are on the market, several are in the clinical trial pipeline, including the anti-tumor drugs angiostatin and endostatin (44). In addition, P. pastoris is one of the only lower eukaryotic expression systems that is available to academic researchers as a complete kit (see Invitrogen catalog). Recent improvements in the system, including new marker host combinations and alternative promoters, should increase the range of proteins that can be produced by this methylotrophic host. As more proteins are successfully (or unsuccessfully) synthesized in P. pastoris, parameters involved with the optimal expression of specific classes of proteins will become better defined.
Down‐regulation by retinoic acid of the catalytic subunit of protein phosphatase type 2A during granulocytic differentiation of HL‐60 cells (1993)

Activity of protein phosphatase measured in the absence of divalent cations was decreased by 50% during all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation into the granulocytic phenotype. Treatment of HL-60 cells with ATRA led to a dramatic decrease in the amount of protein phosphatase type 2A (PP2A) protein, whereas that of protein phosphatase type 1 (PP1) protein was relatively constant, as detected by immunoblotting with antibodies specific to PP1 and PP2A. The decreased phosphatase activity may be mainly due to a decrease in the expression of the PP2A protein. The mRNA level of PP2A beta was markedly decreased within 5 h after addition of ATRA, but there was only a slight increase in the mRNA level of PP2A alpha. Selective down-regulation of PP2A beta mRNA clearly preceded the cell differentiation induced by ATRA treatment. Thus, PP2A is down-regulated during ATRA-induced differentiation of HL-60 cells into granulocytes.
Effect of sample dissolution procedures on x-ray spectrometric analysis of biological materials (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of sample dissolution procedures on x-ray spectrometric analysis of biological materialsPeter A. Pella, Howard M. Kingston, John R. Sieber, and Liang Yuan. FengCite this: Anal. Chem. 1983, 55, 7, 1193–1194Publication Date (Print):June 1, 1983Publication History Published online1 May 2002Published inissue 1 June 1983https://pubs.acs.org/doi/10.1021/ac00258a054https://doi.org/10.1021/ac00258a054research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intracavitary Repair of Ventricular Aneurysm and Regional Dyskinesia (1992)

Myocardial damage after infarction is a common sequela in patients with coronary occlusive disease. The extent of injury varies and may be localized or diffuse. Since March 1989, the authors have used a new surgical repair technique that employs an intracavitary patch of Dacron fabric or glutaraldehyde-treated pericardium to exclude the hypokinetic or fibrotic myocardial segment. An elliptical configuration preserves the contour and volume of the ventricular cavity. After securing the patch, the ventriculotomy is closed with a simple continuous suture. Through July 31, 1991, 136 patients underwent repair using this technique. Of these patients, 100 (group I) had neither sustained an acute myocardial infarction (within 30 days before surgery) nor had undergone previous cardiac surgery, whereas 36 (group II) had sustained an acute myocardial infarction or had undergone previous cardiac surgery. In group I, four (4%) died within 30 days of surgery, and seven died later, resulting in a 6-month survival of 90.5% and a 1-year survival of 85.3%. In group II, 11 (30.6%) died within 30 days of surgery, and three died later. Functional class improved after repair in 95.7% of patients in group I and all patients in group II. In both groups, ejection fraction improved significantly (p less than 0.0001, group I; p less than 0.0001, group II). By eliminating the need for epicardial buttresses to repair the ventriculotomy, myocardial revascularization has been possible in most patients. This method of intraventricular repair is also appropriate for patients with calcified aneurysms, acquired ventricular septal defects, and acute ventricular rupture.
Energy-Saving Massive Access Control and Resource Allocation Schemes for M2M Communications in OFDMA Cellular Networks (2012)

Machine-to-Machine communication recently becomes a popular issue in 4G Standardization Committee, such as IEEE 802.16p and LTE-A. In an OFDMA cellular network embedded with a M2M system, the energy consumption (EC) minimization problem is formulated with the consideration of transmission and circuit energy consumed. We propose joint massive access control and resource allocation (RA) schemes, which perform machine node grouping, coordinator selection, and coordinator RA, and also determine the proper number of groups under a 2-hop transmission protocol, to minimize total EC in both flat- and frequency-selective fading channel. Numerical results show that proposed schemes can achieve sub-optimal EC.
Static electricity in the petroleum industry (1958)

Many fires of unknown origin can justifiably be traced to static electricity. Increased knowledge has improved protection but the still unsolved static problems have assumed serious proportions because of the much broader explosive range of jet fuels compared with gasoline.
Dynamics and Heat Transfer Associated With a Single Bubble During Nucleate Boiling on a Horizontal Surface (1999)

In this study, a complete numerical simulation of a growing and departing bubble on a horizontal surface has been performed. A finite difference scheme is used to solve the equations governing conservation of mass, momentum, and energy in the vapor-liquid layers. The vapor-liquid interface is captured by a level set method which is modified to include the influence of phase change at the liquid-vapor interphase. The disjoining pressure effect is included in the numerical analysis to account for heat transfer through the liquid microlayer. From the numerical simulation, the location where the vapor-liquid interface contacts the wall is observed to expand and then retract as the bubble grows and departs. The effect of static contact angle and wall superheat on bubble dynamics has been quantified. The bubble growth predicted from numerical analysis has been found to compare well with the experimental data reported in the literature and that obtained in this work.
Seizure‐dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus (2002)

Mitochondrial function is a key determinant of both excitability and viability of neurons. Here, we demonstrate seizure-dependent changes in mitochondrial oxidative phosphorylation in the epileptic rat hippocampus. The intense pathological neuronal activity in pilocarpine-treated rats exhibiting spontaneous seizures resulted in a selective decline of the activities of NADH-CoQ oxidoreductase (complex I of the respiratory chain) and cytochrome c oxidase (complex IV of respiratory chain) in the CA3 and CA1 hippocampal pyramidal subfields. In line with these findings, high-resolution respirometry revealed an increased flux control of complex I on respiration in the CA1 and CA3 subfields and decreased maximal respiration rates in the more severely affected CA3 subfield. Imaging of mitochondrial membrane potential using rhodamine 123 showed a lowered mitochondrial membrane potential in both pyramidal subfields. In contrast to the CA1 and CA3 subfields, mitochondrial oxidative phosphorylation was unaltered in the dentate gyrus and the parahippocampal gyrus. The changes of oxidative phosphorylation in the epileptic rat hippocampus cannot be attributed to oxidative enzyme modifications but are very likely related to a decrease in mitochondrial DNA copy number as shown in the more severely affected CA3 subfield and in cultured PC12 cells partially depleted of mitochondrial DNA. Thus, our results demonstrate that seizure activity downregulates the expression of mitochondrial-encoded enzymes of oxidative phosphorylation. This mechanism could be invoked during diverse forms of pathological neuronal activity and could severely affect both excitability and viability of hippocampal pyramidal neurons.
Foreword: Interesting Times (2011)

1. Owain Self
 1. is the Global Co-Head of Direct Execution and Global Head of Algorithmic Trading at UBS in London,U.K., CT, and NY.

If you asked me to characterize the nature of global liquidity over the last year, my polite answer would be “it’s been interesting.” Much like the
Discrépances de suites associées à un système de numération (en dimension un) (1981)

Nous dfinissons une famille de suites associes un systme de numration pour lesquelles nous savons dterminer, par des formules explicites, la discrpance et la discrpanoe l'origine. L'tude asymptotique ralise pour deux classes particulires, permet notamment d'obtenir les plus faibles discrpances actuellement connues : 0,22... pour la discrpance l'origine et 0,37... pour la discrpance.
Pre-screen projection (1995)

Pre-screen projection is a new interaction technique that allows a user to pan and zoom integrally through a scene simply by moving his or her head relative to the screen. The underlying concept is based on real-world visual perception, namely, the fact that a person’s view changes as the head moves. Pre-screen projection tracks a user’s head in three dimensions and alters the display on the screen relative to head position, giving a natural perspective effect in response to a user’s head movements. Specifically, projection of a virtual scene is calculated as if the scene were in front of the screen. As a result, the visible scene displayed on the physical screen expands (zooms) dramatically as a user moves nearer. This is analogous to the real world, where the nearer an object is, the more rapidly it visually expands as a person moves toward it. Further, with pre-screen projection a user can navigate (pan and zoom) around a scene integrally, as one unified activity, rather than performing panning and zooming as separate tasks. This paper describes the technique, the real-world metaphor on which it is conceptually based, issues involved in iterative development of the technique, and our approach to its empirical evaluation in a realistic application testbed.
<i>Caenorhabditis elegans</i>: A new model organism for studies of axon regeneration (2010)

Axonal regeneration in Caenorhabditis elegans was first reported five years ago. Individual green fluorescent protein-labeled axons can be severed using laser microsurgery and their regrowth followed in vivo. Several neuron types display robust regrowth after injury, including motor and sensory neurons. The small size and transparency of C. elegans make possible large-scale genetic and pharmacological screens for regeneration phenotypes.
Long noncoding RNA expression profile in fibroblast-like synoviocytes from patients with rheumatoid arthritis (2016)

The results indicate that the dysregulation of ENST00000483588, ENST00000438399, uc004afb.1, and ENST00000452247 may be involved in the pathological processes of RA and that these lncRNAs may have potential value for the diagnosis and assessment of the disease activity of RA.
Voice traffic performance measurement in packet networks (2003)

Quality of voice transportation over packet networks depends on three critical parameters: packet loss, absolute packet delay and packet delay variation (jitter). Common practical problem is how to estimate voice quality for a different number of voice sources with different source characteristics in target networks. Important characteristics of a voice source are: rate (packets per second), packet length (depending on a type of compression), type of source (VBR or CBR) and statistical description. In this paper we propose methodology and practical approach for systematic measurement of voice traffic parameters in respect to varying voice source characteristics. Measurement results that are conducted with presented methodology on an experimental DiffServ network are given, too.
The role of aldo‐keto reductase 1<scp>C</scp>3 (<scp>AKR</scp>1<scp>C</scp>3)‐mediated prostaglandin <scp>D</scp>2 (<scp>PGD</scp>2) metabolism in keloids (2015)

Keloids are progressively expanding scars, mostly prevalent in individuals of African descent. Previous data identified increased mast cell number and activation state in keloids suggesting a role in disease progression. The major eicosanoid secreted by mast cells is prostaglandin D2 (PGD2), a relatively unstable pro-inflammatory mediator which can be spontaneously converted to 15-deoxy-(Delta12,14)-prostaglandin J2(15d-PGJ2) or enzymatically metabolized to 9α,11β-PGF2 by aldo-keto reductase 1C3 (AKR1C3). In this work, we investigated the possible role of PGD2 and its metabolites in keloids using CRL1762 keloid fibroblasts (KF) and immunohistochemical staining. Our data suggested approximately 3-fold increase of tryptase-positive mast cell count in keloids compared with normal skin. Furthermore, AKR1C3 was overexpressed in the fibrotic area of keloids while relatively weak staining detected in normal skin. Metabolism of PGD2 to 9α,11β-PGF2 by both, KF and normal fibroblasts, was dependent on AKR1C3 as this reaction was attenuated in the presence of the AKR1C3 inhibitor, 2'-hydroxyflavanone, or in cells with decreased AKR1C3 expression. 15d-PGJ2, but not the other tested PGs, inhibited KF proliferation, attenuated KF-mediated collagen gel contraction and increased caspase-3 activation. In addition, treatment with 15d-PGJ2 activated P38-MAPK, induced reactive oxygen species and upregulated superoxide dismutase-1 (SOD-1). Finally, inhibition of P38-MAPK further augmented 15d-PGJ2-induced caspase-3 cleavage and attenuated its effect on SOD-1 transcription. This work suggests that localized dual inhibition of AKR1C3 and P38-MAPK may inhibit keloid progression. Inhibiting AKR1C3 activity may generate oxidative environment due to redirection of PGD2 metabolism towards 15d-PGJ2 while inhibition of P38-MAPK will sensitize keloid cells to ROS-induced apoptosis.
A 6b 3GS/s 11mW fully dynamic flash ADC in 40nm CMOS with reduced number of comparators (2012)

A 6b 3GS/s fully dynamic flash ADC is fabricated in 40nm CMOS and occupies 0.021mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Dynamic comparators with digitally controlled built-in offset are realized with imbalanced tails. Half of the comparators are substituted with simple SR latches. The ADC achieves SNDRs of 36.2dB and 33.1dB at DC and Nyquist, respectively, while consuming 11mW from a 1.1V supply.
Adaptive multiple separation based on information maximization (2012)

We are interested in the problem of separating primary and multiple seismic signals based on their statistical properties. We present a novel adaptive subtraction method based on an information maximization principle. Compared with previous methods, our proposed method has the theoretical advantages of utilizing higher-order statistics of the data and incorporating the filtering nature of the adaptive subtraction problem into our algorithm formulation. Furthermore, our proposed method provides a flexible framework for simultaneously subtracting more than one set of multiple predictions from the input data. We use simulations to show that our proposed adaptive subtraction method outperforms the popular least-square adaptive subtraction and the independent component analysis methods both quantitatively, as measured by the mean-squared error, and qualitatively, as evaluated by the visual quality of the image reconstruction.