gebhart/patrepeval huggingface dataset:
Federated Service-Based Authentication Provisioning for Distributed Diagnostic Imaging Systems (2015)

Diagnostic Imaging systems record and manage the patients' medical images and relevant reports in digital formats. A modern distributed diagnostic imaging system includes PACS (Picture Archiving and Communication System), image viewers, and a large central repository that provides non-proprietary sharing of medical images among clinicians across geographically distributed hospitals. The lack of adequate interface with common infrastructures has made the proprietary PACS systems as closed environments and prevents seamless integration and interoperation with common infrastructures. In terms of security, there is no federated authentication mechanism for PACS systems and each PACS system controls the user identity locally. We propose a service based middleware for distributed diagnostic imaging systems by employing different types of agents in order to achieve a federated authentication mechanism for such systems.
Chromatographic determination of cystine as cysteic acid (1954)

Research Article| May 01 1954 Chromatographic determination of cystine as cysteic acid E. Schram; E. Schram 1Laboratory of Biochemistry, Faculty of Medicine, University of Brussels Search for other works by this author on: This Site PubMed Google Scholar S. Moore; S. Moore * 1Laboratory of Biochemistry, Faculty of Medicine, University of Brussels Search for other works by this author on: This Site PubMed Google Scholar E. J. Bigwood E. J. Bigwood 1Laboratory of Biochemistry, Faculty of Medicine, University of Brussels Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1954) 57 (1): 33–37. https://doi.org/10.1042/bj0570033 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation E. Schram, S. Moore, E. J. Bigwood; Chromatographic determination of cystine as cysteic acid. Biochem J 1 May 1954; 57 (1): 33–37. doi: https://doi.org/10.1042/bj0570033 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search © 1954 CAMBRIDGE UNIVERSITY PRESS1954 Article PDF first page preview Close Modal You do not currently have access to this content.
FERRITIN: STRUCTURE, GENE REGULATION, AND CELLULAR FUNCTION IN ANIMALS, PLANTS, AND MICROORGANISMS (1987)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
CIRCADIAN DRINKING PATTERN OF SARDINIAN ALCOHOL-PREFERRING RATS (1996)

The present study was designed to assess the temporal pattern of ethanol intake over a 24 h period in selectively bred, Sardinian alcohol-preferring (sP) rats. Ethanol intake occurred under the two-bottle, free choice regimen. sP rats consumed ethanol in three distinct peaks, rather regularly distributed over the 12 h dark phase of the light-dark cycle and positively correlated with food intake episodes. The temporal distribution of ethanol intake and estimated blood alcohol levels are consistent with the hypothesis that sP rats voluntarily drink ethanol for its pharmacological effects.
Immunomodulating effects of tofizopam (Grandaxin<sup>®</sup>) and diazepam <i>in vitro</i> (2002)

Benzodiazepines (BDZs) are known to act not only in the central nervous system, but on peripheral cells and tissues binding to the peripheral-type benzodiazepine receptors. In the present study, the influence of two different BDZs (diazepam (Dz) and tofizopam (Tof) on several immune functions has been examined in vitro. Some differences between Dz and Tof in their effects on human lymphocyte proliferative response, changes in glucocorticoid-induced suppression of cell proliferation and influence on cytokine production (tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2)) have been determined. Dz suppressed mitogen-induced peripheral blood mononuclear cell (PBMC) proliferation, enhanced dexamethasone-induced inhibition of PBMC proliferative response, and suppressed lymphocyte production of TNF-alpha and IL-2. Tof usually enhanced PBMC proliferation and IL-2 production in low and moderate doses, but in high doses it suppressed both. Tof in all investigated doses enhanced dexamethasone-induced suppression of lymphocyte proliferation and depressed TNF-alpha production. Thus, both Dz and Tof are shown to have immunomodulating effects in vitro. Tof, opposite to Dz even in the therapeutic doses, is able to enhance in vitro mitogen-induced lymphocyte proliferation and IL-2 production.
Location-Based Services on the Cloud (2009)

In the past decades, location-based services have experienced its first generation, in which a user is provided with some specific services in terms of their geo-location. The prosperity of Cloud computing brings new opportunities for LBS and push LBS to a new era. In cloud-based LBS, location information is still generated in each user’s mobile client but is aggregated in the cloud. People can share their information among each other via the cloud. Moreover, LBS providers can mine knowledge from these location datasets of large-scale users and better server each user in turn using the knowledge. Overall, the future of LBS is on the cloud.
ChemInform Abstract: Synthesis of Thiazolyl‐pyrazolines and Isoxazolines from Acrylothiazoles and Their Microbial Activity. (1987)

Abstract The thiazoles (III) (no yields given) serve as starting material for the synthesis of the desired title compounds (V) and (VII).
Consequences of the molecular mechanism of amyloid formation for the understanding of the pathogenesis of Alzheimer's disease and the development of therapeutic strategies. (1995)

Amyloid formation in the brain is diagnostic of Alzheimer's disease (AD). However, it is not known whether amyloidogenesis precedes and possibly causes cell death or is a byproduct of cell lysis. In any event, it is critical to understand the time course of amyloid formation. The mechanism of amyloidogenesis has been studied in a simple in vitro model system which can be modified to dissect the factors which may be important in vivo. The studies described herein deal with two factors which are known to be important in vivo; the length of the beta protein C-terminus and the endogenous molecule apolipoprotein E (apoE). It could be shown that the C-terminal sequence of the beta-amyloid protein is a critical determinant of the rate of amyloid formation. This discovery led us to propose that the production of the C-terminally extended variants may be a pathogenic event in familial AD. The APOE allele has been shown to be a susceptibility factor for non-familial AD. The apoE variants have been shown to be amyloid nucleation inhibitors. These proteins probably serve as endogenous amyloid suppressors.
Phosphorylated HSP27 essential for acetylcholine-induced association of RhoA with PKCα (2004)

Reorganization of the cytoskeleton and association of contractile proteins are important steps in modulating smooth muscle contraction. Heat shock protein (HSP) 27 has significant effects on actin cytoskeletal reorganization during smooth muscle contraction. We investigated the role of phosphorylated HSP27 in modulating acetylcholine-induced sustained contraction of smooth muscle cells from the rabbit colon by transfecting smooth muscle cells with phosphomimic (3D) or nonphosphomimic (3G) HSP27. In 3G cells, the initial peak contractile response at 30 s was inhibited by 25% (24.0 +/- 4.5% decrease in cell length, n = 4). The sustained contraction was greatly inhibited by 75% [9.3 +/-.9% decreases in cell length (n = 4)]. Furthermore, in 3D cells, translocation of both PKCalpha and of RhoA was greatly enhanced and resulted in a greater association of PKCalpha-RhoA in the membrane fraction. In 3G transfected cells, PKCalpha and RhoA failed to translocate in response to stimulation with acetylcholine, resulting in an inhibition of association of PKCalpha-RhoA in the membrane fraction. Studies using GST-RhoA fusion protein indicate that there is a direct association of RhoA with PKCalpha and with HSP27. The results suggest that phosphorylated HSP27 plays a crucial role in the maintenance of association of PKCalpha-RhoA in the membrane fraction and in the maintenance of acetylcholine-induced sustained contraction.
Perspectives in Diabetes Clinical Trials of Diabetic Neuropathy: Past, Present, and Future (1995)

This article reviews current knowledge of the etiology of diabetic neuropathy and the outcomes and limitations of previous trials and discusses future directions for the investigation of its prevention and treatment. Proposed mechanisms for the development of diabetic neuropathy have been widely studied. It has been shown that there is improvement of nerve function associated with some short-term clinical trials of treatments that address a number of possible etiologic pathways. Improvement of morphometry has also been demonstrated in some short-term clinical trials. However, with the exception of the Diabetes Control and Complications Trial (DCCT), long-term trials with adequate statistical power to evaluate clinical outcome endpoints have not been conducted. The changes in nerve function are similar in most of the
Chemistry in Living Cells: Detection of Active Proteasomes by a Two‐Step Labeling Strategy (2003)

In vivo targeting of the proteasome: Probe 1 is a cell-permeable irreversible inhibitor that alkylates the active-site residues of the proteasome in a Michael fashion. After cell lysis, a biotin moiety is introduced by Staudinger ligation to yield construct 2. This strategy allows activity profiling of the catalytic activities of the proteasome in vivo. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51314_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Laser Digital Cinema Projector (2008)

The reason for wider color gamut of laser display systems rests on RGB laser lights whose color coordinates very approach the locus of gamut chart, which means the most saturated colors. A novel, practical and simplest method to reduce the laser speckle is developed. A laser digital cinema projector (LDCP) is manufactured for the first time in the world. The LDCP enjoys all benefits of 166% NTSC expanded color gamut, beyond 9 024 ANSI lumens light output, a minimum sequential contrast ratio of 2595:1, 2048 X 1080 display resolution, etc.
Micromachined integrated pressure—thermal sensors on flexible substrates (2006)

This paper presents the design, modeling and simulation of micromachined, integrated pressure–thermal sensors on flexible polyimide substrates. Finite element simulations were performed with polycrystalline silicon as the piezoresistor material on a suspended Si3N4 layer. These piezoresistors are connected to each other in a half-bridge Wheatstone configuration using flexible aluminum interconnects. Several different designs of integrated thermal–pressure sensors as well as pressure-only sensors were simulated to compute the sensor figures of merit such as the percentage change in piezoresistance in response to normal pressure, piezoresistor Wheatstone-bridge output voltage for varying skin curvature, bolometric response to broadband infrared radiation, thermal time constant and thermal conductance of the micromachined structures hosting the sensors to the substrate. For a perpendicular uniform pressure application of 50 kPa, a maximum Wheatstone-bridge output of 7.59 mV was computed for 1 V bias, corresponding to a piezoresistance change of 1.52%. When the skin is bent to a curvature of 2.2 mm, a maximum Wheatstone-bridge output voltage of 70 mV was calculated for the case when the sensors are aligned along the axis of bending. Thermal and optical calculations performed on the integrated thermal–pressure sensors showed a thermal time constant as low as 12.8 µs for a 1.9 µm thick silicon nitride membrane layer, with a responsivity of 270 V W−1 to a broad-band infrared radiation. This would be appropriate for applications requiring fast response but not high sensitivity. Integrated sensors on a thinner silicon nitride membrane layer of 0.5 µm, on the other hand, exhibited responsivity as high as 2000 V W−1, with a response time of 626 µs.
ChemInform Abstract: Improved Syntheses of Thieno(2,3‐b)‐ and (3,2‐b)‐fused Naphthyridines. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Etiology of Gas Bubble Disease (1980)

Gas bubble disease is a noninfectious, physically induced process caused by uncompensated hyperbaric pressure of total dissolved gases. When pressure compensation is inadequate, dissolved gases may form emboli (in blood) and emphysema (in tissues). The resulting abnormal physical presence of gases can block blood vessels (hemostasis) or tear tissues, and may result in death. Population mortality is generally skewed, in that the median time to death occurs well before the average time to death. Judged from mortality curves, three stages occur in gas bubble disease: (1) a period of gas pressure equilibrium, nonlethal cavitation, and increasing morbidity; (2) a period of rapid and heavy mortality; and (3) a period of protracted survival, despite lesions, and dysfunction that eventually terminates in total mortality. Safe limits for gas supersaturation depend on species tolerance and on factors that differ among hatcheries and rivers, between continuous and intermittent exposures, and across ranges of temperature and salinity.
Characterization and elimination of dry etching damaged layer in Pt/Pb(Zr0.53Ti0.47)O3/Pt ferroelectric capacitor (1999)

The damage of Pb(Zr0.53Ti0.47)O3 thin film due to dry etching process was characterized in terms of the microstructure and electrical properties. The damaged layer seems to be amorphous and the thickness of the damaged layer is about 10 nm. The existence of such a layer in Pt/Pb(Zr0.53Ti0.47)O3/Pt ferroelectric capacitor tends to increase the coercive voltage and the leakage current. The damaged layer was not fully reverted to perovskite phase by the thermal annealing. With the wet cleaning treatment, however, the damaged layer was successfully removed thereby revealing significantly improved electrical properties.
Radiation and High-Dose Metronidazole in Supratentorial Glioblastomas (1976)

We used "high-dose" metronidazole, an "in vitro" and "in vivo" specific radiosensitizer of hypoxic cells, in a controlled trial to evaluate possible enhancement of radiation effect in patients with supratentorial glioblastomas. Thirty-six patients were stratified according to functional level and randomly allocated within two weeks of operation to one of two therapeutic groups: Group 1, radiation alone; and Group 2, radiation as in Group 1 but with high-dose metronidazole. We examined survival with the Kaplan-Meier probability plot and non-parametric tests. Patients in Group 2 had a 4 1/2-month delay between relapse and subsequent death (P = 0.02). This shift of the survival curves suggests a delay in the time of tumor regrowth consistent with the ability of metronidazole to make the hypoxic tumor cells less radioresistant. Nitroimidazole derivatives may be useful radiosensitizers in human solid tumors.
Defining Pulsatile Perfusion: Quantification in Terms of Energy Equivalent Pressure (1999)

Several clinical and animal studies have demonstrated that pulsatile perfusion is more beneficial than nonpulsatile perfusion during short or long durations of extracorporeal circulation. Other investigators, however, have been unable to document these benefits. The issue remains controversial. Central to the debate is the issue of a precise definition of pulsatile flow. To help resolve the conflict, pulsatile flow may be quantified in terms of energy equivalent pressure. This formula contains both the arterial pressure and pump flow rate, which are the 2 most critical parameters for open heart surgery. This definition establishes common criteria for assessment of the effectiveness of extracorporeal support.
Cognitive radio networking and communications: an overview (2011)

Cognitive radio (CR) is the enabling technology for supporting dynamic spectrum access: the policy that addresses the spectrum scarcity problem that is encountered in many countries. Thus, CR is widely regarded as one of the most promising technologies for future wireless communications. To make radios and wireless networks truly cognitive, however, is by no means a simple task, and it requires collaborative effort from various research communities, including communications theory, networking engineering, signal processing, game theory, software–hardware joint design, and reconfigurable antenna and radio-frequency design. In this paper, we provide a systematic overview on CR networking and communications by looking at the key functions of the physical (PHY), medium access control (MAC), and network layers involved in a CR design and how these layers are crossly related. In particular, for the PHY layer, we will address signal processing techniques for spectrum sensing, cooperative spectrum sensing, and transceiver design for cognitive spectrum access. For the MAC layer, we review sensing scheduling schemes, sensing-access tradeoff design, spectrum-aware access MAC, and CR MAC protocols. In the network layer, cognitive radio network (CRN) tomography, spectrum-aware routing, and quality-of-service (QoS) control will be addressed. Emerging CRNs that are actively developed by various standardization committees and spectrum-sharing economics will also be reviewed. Finally, we point out several open questions and challenges that are related to the CRN design.
Peptides of a biologically active tryptic digest of bovine growth hormone (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPeptides of a biologically active tryptic digest of bovine growth hormoneNobuyuki Yamasaki, Motosuke Kikutani, and Martin SonenbergCite this: Biochemistry 1970, 9, 5, 1107–1114Publication Date (Print):March 1, 1970Publication History Published online1 May 2002Published inissue 1 March 1970https://pubs.acs.org/doi/10.1021/bi00807a009https://doi.org/10.1021/bi00807a009research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center (2003)

Staphylococcus aureus strain HMC3 isolated at the Hershey Medical Center, was resistant to vancomycin (VRSA) through the presence of the vanA resistance gene; it also contained mecA, erm(A), erm(B), tet(K) and aac(6')-aph(2"), conferring resistance to licensed beta-lactams, macrolides, tetracycline and aminoglycosides. HMC3 also had alterations in GyrA and GrlB and was resistant to available quinolones. Experimental drugs with low MICs (<2 mg/L) for VRSA HMC3 included cephalosporins BAL9141 and RWJ-54428; glycopeptides oritavancin and dalbavancin; the lipopeptide daptomycin; the glycolipodepsipeptide ramoplanin; new fluoroquinolones WCK 771 A, WCK 1153, DK-507k and sitafloxacin; and the DNA nanobinder GS02-02. These agents were all bactericidal as were trimethoprim/sulfamethoxazole and teicoplanin (MIC 4 mg/L). Oxazolidinones linezolid and ranbezolid; the injectable streptogramin quinupristin/dalfopristin; DNA nanobinders GS2-10547 and GS02-104; peptide deformylase inhibitors NVP-PDF713 and GS02-12; tetracycline derivative tigecycline; the antifolate iclaprim; mupirocin and fusidic acid were all active in vitro but bacteriostatic.
Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells (2008)

Insulin receptor (IR) signaling provides a trophic signal for transformed retinal neurons in culture, but the role of IR activity in vivo is unknown. We previously reported that light causes increased tyrosine phosphorylation of the IR in vivo, which leads to the downstream activation of the phosphoinositide 3-kinase and Akt pathway in rod photoreceptor cells. The functional role of IR in rod photoreceptor cells is not known. We observed that light stress induced tyrosine phosphorylation of the IR in rod photoreceptor cells, and we hypothesized that IR activation is neuroprotective. To determine whether IR has a neuroprotective role on rod photoreceptor cells, we used the Cre/lox system to specifically inactivate the IR gene in rod photoreceptors. Rod-specific IR knock-out mice have reduced the phosphoinositide 3-kinase and Akt survival signal in rod photoreceptors. The resultant mice exhibited no detectable phenotype when they were raised in dim cyclic light. However, reduced IR expression in rod photoreceptors significantly decreased retinal function and caused the loss of photoreceptors in mice exposed to bright light stress. These results indicate that reduced expression of IR in rod photoreceptor cells increases their susceptibility to light-induced photoreceptor degeneration. These data suggest that the IR pathway is important for photoreceptor survival and that activation of the IR may be an essential element of photoreceptor neuroprotection.