gebhart/patrepeval huggingface dataset:
Inter‐individual variation in half‐life of infused recombinant factor VIII is related to pre‐infusion von Willebrand factor antigen levels (1995)

In an attempt to explain the substantial inter-individual variability in half-life of infused factor VIII (FVIII) among haemophilia A patients, we studied the correlation of pre-infusion von Willebrand factor antigen (vWFAg) levels and the half-life of a recombinant-DNA-derived FVIII (r-VIII SQ. Pharmacia, Sweden). Intra-individual variation in half-life was small (range of variation 0-2.1 h) in 12 severely affected haemophiliacs who received two doses of FVIII concentrate. In contrast, inter-individual variation in half-life was large (range of half-lives 6-28.8 h). A strong correlation between half-life and pre-infusion vWFAg levels was present (r = 0.87, P = 0.0003). We conclude that the half-life of infused recombinant FVIII is related to pre-infusion vWFAg levels in severely affected haemophilia A patients.
Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore–microtubule interactions (2007)

Mitotic phosphorylation of the spindle checkpoint component BubR1 is highly conserved throughout evolution. Here, we demonstrate that BubR1 is phosphorylated on the Cdk1 site T620, which triggers the recruitment of Plk1 and phosphorylation of BubR1 by Plk1 both in vitro and in vivo. Phosphorylation does not appear to be required for spindle checkpoint function but instead is important for the stability of kinetochore-microtubule (KT-MT) interactions, timely mitotic progression, and chromosome alignment onto the metaphase plate. By quantitative mass spectrometry, we identify S676 as a Plk1-specific phosphorylation site on BubR1. Furthermore, using a phospho-specific antibody, we show that this site is phosphorylated during prometaphase, but dephosphorylated at metaphase upon establishment of tension between sister chromatids. These findings describe the first in vivo verified phosphorylation site for human BubR1, identify Plk1 as the kinase responsible for causing the characteristic mitotic BubR1 upshift, and attribute a KT-specific function to the hyperphosphorylated form of BubR1 in the stabilization of KT-MT interactions.
Novel Anti-forensics Approaches for Smart Phones (2012)

Anti-forensics is defined as a method undertaken to thwart the digital investigation process conducted by forensic investigators. In this paper we introduce the design and implementation of three novel anti-forensic approaches for data deletion and manipulation on three of the market-leading forensics tools. The evaluation results of our proposed anti-forensic approaches on a typical Android cell phone device demonstrate the severe limitations of current forensic tools and conclude the critical need for modifications and/or redesigns of these contemporary forensic tools to maintain accuracy and legitimacy of forensic data acquisition and analysis.
Endothelial nitric oxide synthase-deficient mice exhibit increased susceptibility to endotoxin-induced acute renal failure (2004)

Acute renal failure (ARF) in septic patients drastically increases the mortality to 50-80%. Nitric oxide (NO) has been shown to be increased in sepsis. Endothelial nitric oxide synthase (eNOS) is one of the major regulators of arterial blood pressure and regional blood flow; however, its in vivo role in septic ARF is still unclear. We hypothesized that eNOS affords a protective effect against the renal vasoconstriction during endotoxemia. Because there are no specific inhibitors for eNOS, the study was therefore undertaken in eNOS knockout mice. There was no significant difference in baseline glomerular filtration rate (GFR) between the wild-type mice and the eNOS knockout mice (140 +/- 10 vs. 157 +/- 18 microl/min, n = 9, P = not significant). However, renal blood flow (RBF) was significantly decreased in eNOS knockout mice compared with the wild-type controls (0.62 +/- 0.05 ml/min, n = 6 vs. 0.98 +/- 0.13 ml/min, n = 8, P < 0.05). Mean arterial pressure (MAP) was significantly higher in eNOS knockout mice than the wild-type controls (109 +/- 5 vs. 80 +/- 1 mmHg, n = 10, P < 0.01). Thus renal vascular resistance (RVR) was much higher in eNOS knockout mice than in the wild-type mice (176 +/- 2, n = 6 vs. 82 +/- 1 mmHg.ml(-1).min(-1), n = 8, P < 0.01). When 1.0 mg/kg LPS was injected, there was no change in MAP in either the wild-type (84 +/- 3 mmHg, n = 10) or the eNOS knockout mice (105 +/- 5 mmHg, n = 10). Although GFR (154 +/- 22 microl/min, n = 8) and RBF (1.19 +/- 0.05 ml/min, n = 9) remained unchanged with the 1.0-mg/kg dose of LPS in the wild-type mice, GFR (83 +/- 18 vs. 140 +/- 10 microl/min, n = 6, P < 0.01) and RBF (0.36 +/- 0.04 vs. 0.62 +/- 0.05 ml/min, n = 6, P < 0.01) decreased significantly in the eNOS knockout mice. Fractional excretion of sodium increased significantly in eNOS knockout mice during endotoxemia (3.61 +/- 0.78, n = 7 vs. 0.95 +/- 0.14, n = 6, P < 0.01), whereas it remained unchanged in the wild-type mice (0.59 +/- 0.16, n = 9 vs. 0.42 +/- 0.05, n = 6, P = not significant). In summary, eNOS knockout mice have increased RVR and are more susceptible to endotoxemic ARF than wild-type mice despite higher MAP.
Characterizations and Some Chemical Reactions of Periodate-oxidized Nucleosides<sup>2</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterizations and Some Chemical Reactions of Periodate-oxidized Nucleosides2Joseph X. Khym and Waldo E. CohnCite this: J. Am. Chem. Soc. 1960, 82, 24, 6380–6386Publication Date (Print):December 1, 1960Publication History Published online1 May 2002Published inissue 1 December 1960https://pubs.acs.org/doi/10.1021/ja01509a046https://doi.org/10.1021/ja01509a046research-articleACS PublicationsRequest reuse permissionsArticle Views238Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Difficulty with diagnosis of malignant pancreatic neoplasms coexisting with chronic pancreatitis (2005)

Chronic pancreatitis is a relatively common disease. We encountered two different cases of belatedly demonstrated pancreatic carcinoma featuring underlying chronic pancreatitis. The first case was one that was highly suspected as that of a malignancy based upon imaging study, but unfortunately, it could not be confirmed by intra-operative cytology at that time. Following this, the surgeon elected to perform only conservative bypass surgery for obstructive biliary complication. Peritoneal carcinomatosis was later noted and the patient finally died. The second case, a malignant mucinous neoplasm, was falsely diagnosed as a pseudocyst, based upon the lesion's sonographic appearance and associated elevated serum amylase levels. After suffering repeated hemoptysis, the patient was found to exhibit lung metastasis and peritoneal seeding. We reviewed some of the literature, including those studies discussing chronic pancreatitis predisposing to a malignant change. These two case analyses illustrate clearly that the diagnosis for such conditions, which is simply based upon imagery or pathological considerations may end up being one of a mistaken malignancy. Some of our suggestions for the treatment of such malignancies as revealed herein include, total pancreatomy for univocal mass lesion, and needle aspiration of lesion-contained tissue for amylase, CA199 and CEA levels for a suspicious cystic pancreatic mass.
An optimized design of under-sampling 100MHz-10b time-interleaved pipelined ADC (2010)

An under-sampling high speed pipelined ADC is proposed with optimized two-channel time-interleaved architecture. The two channels have a common SHA which is designed for under-sampling while the clock frequency in each channel is half of it in SHA. And in the two-channel time-interleaved pipelined part, the shared operational amplifier compensates for the large mismatch between the channels in each same stage. This design minimizes power consumption and chip area in time-interleaved ADC. Under SMIC 0.35um 1P6M process with 3.3V supply, the performance of SNR reaches nearly 65dB with the condition that the sampling rate is 100MHz and the input frequency is scanned from 1MHz to 110MHz. The current consumption of 100MSps is about 34mA.
Insertion of Ketene and Diphenylketene to the Pnictogen-Heteroatom Bonds (1987)

Abstract Ketene and diphenylketene insert across the heteroatom-metal bond of amino-, alkoxy-, and alkylthiopnictogens, R3−nMXn, to give the corresponding α-metallated acetamides, esters, and thioesters, R3−nM(CH2COX)n and R3−nM(CPh2COX)n (M=As, Sb, Bi; X=NR2, OR, SR; n=1,3), respectively.
Well Log Cluster Analysis: An Innovative Tool for Unconventional Exploration (2010)

Abstract Well Log Cluster Analysis: an Innovative Tool for Unconventional Exploration Tristan Euzen, Eric Delamaide, Tom Feuchtwanger, Kim Kingsmith. Exploring for economically viable accumulations of hydrocarbons, the task of explorationists is becoming considerably more complex in mature basins because of the unconventional nature of most remaining resources. Analyzing a large volume of data is required in order to develop a comprehensive understanding of reservoir distributions and/or their production performance characteristics. Furthermore, the unconventional nature of reservoirs makes it challenging to interpret well log data and indentify potential gas pay using conventional data analysis approaches. Well log cluster analysis is an innovative approach that provides the explorationist with an efficient tool for analyzing, screening and filtering a large volume of well log data, in order to identify and map potential hydrocarbon accumulations. The method involves seeking high density areas (clusters) in the multivariate space of well log data, in order to define classes of similar log responses. These classes called electrofacies can be calibrated using various sources of data such as core description or production data and can then be used to process very quickly hundreds of wells. Cluster analysis and electrofacies classification have been applied to develop unconventional gas prospects in the Upper Mannville incised valley fills of the WCSB. The reservoirs dominantly consist of arkoses with complex mineralogy, and are characterized by both conventional and unconventional production from low resistivity pays. A cluster analysis was first performed on 5 producing wells used as training samples, and an electrofacies classification was then performed on 395 wells in an area of 28 townships. A quality control of the results was done by checking the electrofacies interpretation in front of producing intervals from 41 wells. The preliminary results are very promising, with 89% of the producing intervals used in the blind test properly predicted by the electrofacies classification. Finally, potential gas bearing intervals identified by the electrofacies classification have been mapped in order to define prospective areas. This approach has many potential applications in the field of unconventional hydrocarbons, especially where conventional log analysis doesn't work properly and where a large volume of well log data is available.
An Efficient Multi Queue Job Scheduling for Cloud Computing (2014)

Cloud computing is one of the well developing field in Computer Science and Information Technology. The efficient job scheduling increases the client satisfaction and utilize the system energy in terms of time. A Multi Queue Scheduling (MQS) algorithm proposed to reduces the cost of both reservation and on-demand plans using the global scheduler. Scheduling is the most important complex part in cloud computing. The ultimate aim of global scheduler is to share the resources at most the maximum level. Researcher gives more importance to build a job scheduling algorithms that are well-suited and appropriate in Cloud computing situation. Job scheduling is one of the critical event in cloud computing because the user have to pay for services based on usage time. The proposed methodology depicts the concept of clustering the jobs based on burst time. During the time of scheduling the traditional methods such as First Come First Serve, Shortest Job First, EASY, Combinational Backfill and Improved backfill using balance spiral method are creates fragmentation. The proposed method overcome this problem and reduces the starvation with in the process. This paper also focus some existing scheduling algorithm and issues related to them in cloud computing. The proposed MQS method gives more importance to select job dynamically in order to achieve the optimum cloud scheduling problem and hence it utilize the unused free space in an economic way.
Calcium Phosphate Fertilizers: I. Availability to Plants and Solubility in Soils Varying in pH (1958)

Abstract Availabilities of the phosphorus in six pure crystalline calcium phosphates to ryegrass and Sudangrass were determined in the greenhouse. The crops were grown on three acid soils, Clarksville silt loam, Hartsells fine sandy loam, and Edina silt loam; and on two alkaline soils, Rosebud loam and Webster silty clay loam. Dicalcium phosphate dihydrate was appreciably more available than anhydrous dicalcium phosphate on all soils. Monocalcium phosphate was slightly more available than the dicalcium phosphates on the alkaline soils but was less available on the acid soils. Alpha tricalcium phosphate was nearly as available as anhydrous dicalcium phosphate on the acid soils, but was of very low availability on the alkaline soils. Hydroxyapatite was of very low availability on all soils. Availability of octocalcium phosphate was less than for the dicalcium phosphates and decreased with increasing liming rates on Hartsells fine sandy loam. A significant correlation was found between the phosphorus extracted by 0.5 N NaHCO 3 and the phosphorus uptake by the two crops from the various phosphates. Placing the phosphates in a layer 1½ inches below the surface markedly increased availability to the crops grown in low‐phosphorus Clarksville and Hartsells soils, while mixing with the soil was equally effective in the higher‐phosphorus Edina, Rosebud, and Webster soils.
Supervised Classification of RADARSAT-2 Polarimetric Data for Different Land Features (2016)

The pixel percentage belonging to the user defined area that are assigned to cluster in a confusion matrix for RADARSAT-2 over Vancouver area has been analysed for classification. In this study, supervised Wishart and Support Vector Machine (SVM) classifiers over RADARSAT-2 (RS2) fine quadpol mode Single Look Complex (SLC) product data is computed and compared. In comparison with conventional single channel or dual channel polarization, RADARSAT-2 is fully polarimetric, making it to offer better land feature contrast for classification operation.
Development of a recovery process for novobiocin (1973)

Abstract A periodic countercurrent whole beer process was developed for the recovery of novobiocin to eliminate the high cost of mycelium filtration and accompanying antibiotic losses in the filter cake. In such a process screened, but unfiltered, novobiocin fermentation beer is contacted with a special grade of an anionic‐exchange resin in a series of specially designed, well mixed columns. Each column is fitted with a screen sized to retain resin within the column but allow the cells to press. Periodically the lead column is isolated from the column train, washed free of beer solids, and eluted. A freshly eluted column is placed in the trail position to allow countercurrent operation. The eluate is then processed to crystalline product. A mathematical model for the sorption of novobiocin was developed based on a suitable continuity equation and mass transfer and equilibrium relationships determined in the laboratory. Digital computations of this model correlated well with laboratory and pilot plant data, and predicted well the performance of the production units. This simulation has been in continued use to predict and reoptimize plant operation as process changes (such as improved beer titers, increased production rate, and the evaluation of superior ion‐exchange resins) occurred or were anticipated.
Time-resolved terahertz emission spectroscopy of wide miniband GaAs/AlGaAs superlattices (2002)

We have investigated terahertz (THz) emission due to dynamical electron transport in wide miniband GaAs/Al0.3Ga0.7As superlattices by time-resolved THz emission spectroscopy. Quasiautocorrelation measurements were performed on the emitted THz electromagnetic waves by using a bolometer as a wideband detector. The bias-field dependence of the emitted THz radiation intensity clearly showed a crossover from the miniband transport to the formation of Wannier–Stark ladder. In the Wannier–Stark regime, a few cycle Bloch oscillations were observed even at 300 K in a superlattice whose miniband width is greater than the longitudinal optical phonon energy. Furthermore, it has been found that clear Bloch oscillations are visible only when the bottom of the miniband is photoexcited.
RESEARCH ON ENTERPRISE CORE COMPETENCE AND MANAGERIAL HUMAN RESOURCE STRATEGY (2010)

This paper aims to introduce the meaning, components, dimensions and types of enterprise core competence. In addition, the framework of human resource strategy for managing enterprise core competence is also proposed. To identify enterprise core competence, and discuss the relationship between core competence and human resource strategy, methods of case study and documents analysis are also adopted. Key words: core competency, human resource, strategy
Tyrosine phosphorylation is required for mast cell activation by Fc epsilon RI cross-linking (1992)

We investigated the possible role of tyrosine phosphorylation in the activation process of mast cells by cross-linking of cell-bound IgE antibodies. Bone marrow-derived mouse mast cells (BMMC) were sensitized with mouse IgE antiDNP mAb and then challenged with multivalent Ag DNP conjugates of human serum albumin. Analysis of phosphotyrosine-containing proteins in their lysates by SDS-PAGE and immunoblotting revealed that cross-linking of cell-bound IgE antibodies induced a marked increase in tyrosine phosphorylation of several proteins. To obtain direct evidence for activation of protein-tyrosine kinases (PTK), phosphotyrosine-containing proteins in lysates of mast cells were affinity purified, and kinase activity of the immunoprecipitates was assessed by an in vitro kinase assay. The results clearly showed activation of PTK upon cross-linking of Fc epsilon RI. Activation of PTK was not detected by the same assay when the sensitized BMMC were challenged with monovalent DNP-lysine. Treatment of sensitized BMMC with either Ca2+ ionophore or PMA failed to induce the activation of PTK. A representative IgE-independent secretagogue, thrombin, induced histamine release from BMMC but failed to induce activation of PTK. The results excluded the possibility that PTK activation is the consequence of an increase in intracellular Ca2+ or activation of protein kinase C. Addition of genistein, a PTK inhibitor, to sensitized BMMC before Ag challenge inhibited not only Ag-induced PTK activation, but also inositol 1,4,5-trisphosphate production, and histamine release in a similar dose-response relationship. Other PTK inhibitors, such as lavendustin A and tyrphostin RG50864, also inhibited the Ag-induced activation of PTK and histamine release. The results collectively suggest that activation of PTK is an early event upstream of the activation of phospholipase C, and is involved in transduction of IgE-dependent triggering signals to mediator release.
Action of rat liver cathepsin L on collagen and other substrates. (1982)

1. It has been found that cathepsin L is very susceptible to loss of activity through autolysis. When this is prevented by purification and storage of the enzyme as its mercury derivative, preparations are obtained with higher specific activity than previously. 2. Active-site titration shows, however, that even the new purification method does not give preparations in which the enzyme is 100% active. 3. Benzyloxycarbonylphenylalanylarginine 7-(4-methyl)coumarylamide has been discovered to be a very sensitive substrate for cathepsin L. Like all other known substrates for cathepsin L, however, it is also cleaved by cathepsin B. 4. Cathepsin L degrades insoluble collagen at pH 3.5 over 5-fold faster than at pH 6.0. The specific activity at pH 3.5 is 5-10-fold higher than that of cathepsin B (rat or human) or bovine spleen cathepsin N ('collagenolytic cathepsin'). 5. Qualitatively, the action of cathepsin L on collagen is similar to that of cathepsins B and N, i.e. selective cleavage of terminal peptides leads to conversion of beta- and higher components mainly to alpha-chains.
An interactive broadcasting protocol for video-on-demand (2002)

Broadcasting protocols reduce the cost of video-on-demand services by distributing more efficiently videos that are likely to be simultaneously watched by several viewers. Unfortunately, they do not allow the customer to pause, move fast forward or backward while watching a video. We present an interactive pagoda broadcasting protocol that provides these functions at a very reasonable cost. Our protocol is based on the pagoda broadcasting protocol and requires a set-top box buffer large enough to keep in storage all video data until the customer has watched the entire video. As a result, rewind and pause interactions do not require any server intervention. To minimize the bandwidth requirements of fast forward interactions, the server only transmits the segments that are not available on any of the server broadcasting channels. We evaluate the overhead of these fast forward operations through a probabilistic model. Our data indicate that the most costly fast forward operations are those starting at the beginning of the video and jumping to the beginning of the second half of the video while most fast-forward operation taking place during the second half of the video require little or no additional data.
Preparative Liquid Chromatography of Pharmaceuticals Using Silica Gel with Aqueous Eluents (1986)

Abstract Acidic, basic, and neutral Pharmaceuticals can be easily assayed on silica with aqueous eluents. Because of the nature of these packings, chromatographic methods are more reproducible than bonded phase packings and can be easily scaled up for preparative procedures.