gebhart/patrepeval huggingface dataset:
Evolution of silicon bulk lifetime during III–V‐on‐Si multijunction solar cell epitaxial growth (2015)

Abstract The evolution of Si bulk minority carrier lifetime during the heteroepitaxial growth of III–V on Si multijunction solar cell structures via metal‐organic chemical vapor deposition (MOCVD) has been analyzed. In particular, the impact on Si lifetime resulting from the four distinct phases within the overall MOCVD‐based III–V/Si growth process were studied: (1) the Si homoepitaxial emitter/cap layer; (2) GaP heteroepitaxial nucleation; (3) bulk GaP film growth; and (4) thick GaAs y P 1‐y compositionally graded metamorphic buffer growth. During Phase 1 (Si homoepitaxy), an approximately two order of magnitude reduction in the Si minority carrier lifetime was observed, from about 450 to ≤1 µs. However, following the GaP nucleation (Phase 2) and thicker film (Phase 3) growths, the lifetime was found to increase by about an order of magnitude. The thick GaAs y P 1‐y graded buffer was then found to provide further recovery back to around the initial starting value. The most likely general mechanism behind the observed lifetime evolution is as follows: lifetime degradation during Si homoepitaxy because of the formation of thermally induced defects within the Si bulk, with subsequent lifetime recovery due to passivation by fast‐diffusing atomic hydrogen coming from precursor pyrolysis, especially the group‐V hydrides (PH 3 , AsH 3 ), during the III–V growth. These results indicate that the MOCVD growth methodology used to create these target III–V/Si solar cell structures has a substantial and dynamic impact on the minority carrier lifetime within the Si substrate. Copyright © 2015 John Wiley & Sons, Ltd.
URBANIZATION IN THE WINDSOR-QUEBEC CITY AXIS, 1921-1981 (1984)

Between 1951 and 1971, population and economic activities appeared to be concentrating in the Windsor-Quebec City axis, and a consequence of this was rapid urban growth and the development of a highly interconnected urban corridor. Since 1971, some decentralization of economic activities and population away from the axis appears to have occurred, and the patterns of urban growth within the area are quite varied. In this paper, the 1921-81 fluctuations in concentration/ deconcentration are documented, recent particular geographic shifts are outlined, and a theoretical interpretation of the changes is discussed.
Population Pharmacokinetics of Oseltamivir When Coadministered With Probenecid (2008)

Oseltamivir is a potent, selective, oral neuraminidase inhibitor for the treatment and prophylaxis of influenza. Plasma concentrations of the active metabolite, oseltamivir carboxylate, are increased in the presence of probenecid, suggesting that the combination could allow for the use of reduced doses of oseltamivir. To investigate this proposal, we developed a population pharmacokinetic model and simulated the pharmacokinetics of candidate combination regimens of oral oseltamivir (45 mg and 30 mg twice a day) plus oral probenecid (500 mg/6 hourly). Probenecid plus oseltamivir 45 mg achieved all the pharmacokinetic parameters expected of oseltamivir alone, but combination with oseltamivir 30 mg and dose interval extension approaches did not. An oseltamivir-probenecid combination may compromise tolerability and enhance the potential for drug interactions. In addition, increased dosing requirements may affect compliance and attainment of optimal oseltamivir exposure, potentially facilitating the emergence of viral strains with reduced susceptibility to oseltamivir. These factors, set alongside increased capacity for oseltamivir production, should be carefully considered before an oseltamivir-probenecid combination is used.
Noninvasive stool-based detection of infant gastrointestinal development using gene expression profiles from exfoliated epithelial cells (2010)

We have developed a novel molecular methodology that utilizes stool samples containing intact sloughed epithelial cells to quantify intestinal gene expression profiles in the developing human neonate. Since nutrition exerts a major role in regulating neonatal intestinal development and function, our goal was to identify gene sets (combinations) that are differentially regulated in response to infant feeding. For this purpose, fecal mRNA was isolated from exclusively breast-fed (n = 12) and formula-fed (n = 10) infants at 3 mo of age. Linear discriminant analysis was successfully used to identify the single genes and the two- to three-gene combinations that best distinguish the feeding groups. In addition, putative "master" regulatory genes were identified using coefficient of determination analysis. These results support our premise that mRNA isolated from stool has value in terms of characterizing the epigenetic mechanisms underlying the developmentally regulated transcriptional activation/repression of genes known to modulate gastrointestinal function. As larger data sets become available, this methodology can be extended to validation and, ultimately, identification of the main nutritional components that modulate intestinal maturation and function.
A 256×256 45/65nm 3D-stacked SPAD-based direct TOF image sensor for LiDAR applications with optical polar modulation for up to 18.6dB interference suppression (2018)

Light detection and ranging (LiDAR) systems based on direct time-of-flight (DTOF) are used in spacecraft navigation, assembly-line robotics, augmented and virtual reality (AR/VR), (drone-based) surveillance, advanced driver assistance systems (ADAS), and autonomous cars. Common requirements are accuracy and speed, while ensuring long operating distance, high tolerance to background illumination and robustness to interference from other LiDAR systems. To meet these demands, the DTOF sensor community has provided numerous architectures, typically making use of resource sharing that often introduces tradeoffs between pixel count and speed. If resource sharing is not used, reduced fill factor, high non-uniformity, and pile-up distortion generally arise, thus limiting overall performance [1].
Behavior of Grouted Shaft Helical Anchors in Clay (2011)

AbstractSome years ago, a method was developed to incorporate a grout column around square-shaft helical screw-piles and anchors to increase shaft buckling resistance under compression loading. An additional benefit of this grouted shaft is to increase the load capacity in both compression and tension, depending on the geometry of the lead helical section and the soil conditions. Because of the unique construction procedure, the contribution of the shaft to the total capacity has largely been unknown. The behavior of grouted shaft helical anchors in clay was investigated by performing full-scale axial uplift (tension) load tests on a series of anchors installed at the University of Massachusetts Geotechnical Test Site. In order to isolate the contribution of the grouted shaft to the total load capacity, anchors were installed with a wooden dowel connection between the lead helical section and extension sections on three of the four anchors so that only the shaft resistance would be measured during the loa...
Right-handed double-helix ultrashort DNA yields chiral nematic phases with both right- and left-handed director twist (2010)

Concentrated solutions of duplex-forming DNA oligomers organize into various mesophases among which is the nematic (N(∗)), which exhibits a macroscopic chiral helical precession of molecular orientation because of the chirality of the DNA molecule. Using a quantitative analysis of the transmission spectra in polarized optical microscopy, we have determined the handedness and pitch of this chiral nematic helix for a large number of sequences ranging from 8 to 20 bases. The B-DNA molecule exhibits a right-handed molecular double-helix structure that, for long molecules, always yields N(∗) phases with left-handed pitch in the μm range. We report here that ultrashort oligomeric duplexes show an extremely diverse behavior, with both left- and right-handed N(∗) helices and pitches ranging from macroscopic down to 0.3 μm. The behavior depends on the length and the sequence of the oligomers, and on the nature of the end-to-end interactions between helices. In particular, the N(∗) handedness strongly correlates with the oligomer length and concentration. Right-handed phases are found only for oligomers shorter than 14 base pairs, and for the sequences having the transition to the N(∗) phase at concentration larger than 620 mg/mL. Our findings indicate that in short DNA, the intermolecular double-helical interactions switch the preferred liquid crystal handedness when the columns of stacked duplexes are forced at high concentrations to separations comparable to the DNA double-helix pitch, a regime still to be theoretically described.
Metabolomics, Pathway Regulation, and Pathway Discovery (2011)

Metabolomics is a data-based research strategy, the aims of which are to identify biomarker pictures of metabolic systems and metabolic perturbations and to formulate hypotheses to be tested. It involves the assay by mass spectrometry or NMR of many metabolites present in the biological system investigated. In this minireview, we outline studies in which metabolomics led to useful biomarkers of metabolic processes. We also illustrate how the discovery potential of metabolomics is enhanced by associating it with stable isotopic techniques.
Flow cytometric analysis of DNA content for four commercially important crabs in China (2016)

一个有机体的染色体尺寸(C 值) 正在指它的非复制的 haploid 染色体补充的 DNA 内容，通常从测量体的双原子核推出了。我们介绍了数据为四只商业地重要的螃蟹(Portunus trituberculatus，一种危险的漩涡装饰用的梨树，六头女妖 paramamosain，和 Eriocheir sinensis ) 由流动 cytometry 获得了的染色体尺寸(C 值) 在中国的海岸普通。吊裤带 domesticus (2C=2.5 pg ) 被用作内部标准。结果出现了为 P 的 C 值。trituberculatus， C。装饰用的梨树， S。paramamosain，和 E。sinensis 是(ssDNA 的 2.31ge 数量将被吸收到表面上去，并且这将引起 FP 的强壮的改进。这极化试金被使用为 det 鳐 ? 鳐设计一个方法吗？？
Discovery of Thiadiazoles as a Novel Structural Class of Potent and Selective PDE7 Inhibitors. Part 1. Design, Synthesis and Structure—Activity Relationship Studies. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Economic Consequences of Illness in the Workplace (1995)

When employers focus only on the direct, out-of-pocket costs of health care, they fail to consider the indirect costs of illness in the workplace form workers' impaired functioning on the job and absenteeism. The authors present a case study of the effects of clinical depression on direct and indirect health-related costs and provide a model that employers can apply to a wide range of illnesses to analyze their investments in health care. The authors apply the framework to several workplace situations ? employees' depression, cigarette smoking breaks, and arthritis ? to estimate the costs of lost productivity. They also show how to do a break-even analysis to determine when employers' investments in health interventions are likely justified.
Are You Looking at Me? Eye Gaze and Person Perception (2002)

Previous research has highlighted the pivotal role played by gaze detection and interpretation in the development of social cognition. Extending work of this kind, the present research investigated the effects of eye gaze on basic aspects of the person-perception process, namely, person construal and the extraction of category-related knowledge from semantic memory. It was anticipated that gaze direction would moderate the efficiency of the mental operations through which these social-cognitive products are generated. Specifically, eye gaze was expected to influence both the speed with which targets could be categorized as men and women and the rate at which associated stereotypic material could be accessed from semantic memory. The results of two experiments supported these predictions: Targets with nondeviated (i.e., direct) eye gaze elicited facilitated categorical responses. The implications of these findings for recent treatments of person perception are considered.
A parallel multiblock mesh movement scheme for complex aeroelastic applications (2001)

A scheme has been developed for the movement of multiblock, structured grids due to surface deformation arising from aeroelastics, control surface movement, or design optimization. Elements of the method include a blending of a surface spline approximation and nearest surface point movement for block boundaries. Transfinite interpolation is employed for volume grid deformation. The scheme is demonstrated on a range of simple and complex aeroelastic aircraft applications using Navier-Stokes computational fluid dynamics and modal structural analyses on parallel processors. Results are robust and accurate, requiring only minimal user input specification.
Directionality and polarity in recA protein-promoted branch migration. (1981)

The recA protein of Escherichia coli promotes the complete exchange of strands between full-length linear duplex and single-stranded circular phi X174 DNA molecules. Analysis of the reaction by electron microscopy confirms that D loops containing short heteroduplex regions are rapidly formed at the ends of the linear duplex, followed by a relatively slow branch migration that converts the D loops to nicked circular duplexes (RFII) and displaced linear single strands. Heteroduplex extension and displacement of the linear single strand are concerted. Heterologous sequences within the linear duplex halt branch migration and lead to the accumulation of D loops. Although D loops can be formed at either end of the linear duplex, recA protein-promoted branch migration proceeds uniquely in the 3' leads to 5' direction relative to the (--) strand of the linear duplex.
Paracrine and Autocrine Functions of Brain-derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in Brain-derived Endothelial Cells (2004)

Brain-derived neurotrophic factor (BDNF) is expressed by endothelial cells. We investigated the characteristics of BDNF expression by brain-derived endothelial cells and tested the hypothesis that BDNF serves paracrine and autocrine functions affecting the vasculature of the central nervous system. In addition to expressing TrkB and p75NTR and BDNF under normoxic conditions, these cells increased their expression of BDNF under hypoxia. While the expression of TrkB is unaffected by hypoxia, TrkB exhibits a base-line phosphorylation under normoxic conditions and an increased phosphorylation when BDNF is added. TrkB phosphorylation is decreased when endogenous BDNF is sequestered by soluble TrkB. Exogenous BDNF elicits robust angiogenesis and survival in three-dimensional cultures of these endothelial cells, while sequestration of endogenous BDNF caused significant apoptosis. The effects of BDNF engagement of TrkB appears to be mediated via the phosphatidylinositol (PI) 3-kinase-Akt pathway. Modulation of BDNF levels directly correlate with Akt phosphorylation and inhibitors of PI 3-kinase abrogate the BDNF responses. BDNF-mediated effects on endothelial cell survival/apoptosis correlated directly with activation of caspase 3. These endothelial cells also express p75NTR and respond to its preferred ligand, pro-nerve growth factor (pro-NGF), by undergoing apoptosis. These data support a role for neurotrophins signaling in the dynamic maintenance/differentiation of central nervous system endothelia.
Plasma Surface Modification of Polymer Substrates for Selective Hydrophobic Control (2007)

The main objective of this study is theoretical and experimental investigation of the surfaces modification of SU8, PDMS, SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and Si by plasma RF treatment. Physical-chemical reactions at room temperature can be used for the modifications of the surfaces in plasma, by modifying the contact angle, superficial polymerization, or by creating hydrophilic regions and/or hydrophobic on the surfaces in contact with plasma. The argon-plasma annealing was used to generate the hydrophilic surfaces, and plasma of CF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> or CF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> with O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> has been used to create hydrophobic surfaces.
Memory using diode-coupled bipolar transistor cells (1970)

See abstr. B25024, C13758 of 1970.
The 5′ Untranslated Region and Gag product of <i>Idefix</i>, a Long Terminal Repeat-Retrotransposon from <i>Drosophila melanogaster</i>, Act Together To Initiate a Switch between Translated and Untranslated States of the Genomic mRNA (2003)

Idefix is a long terminal repeat (LTR)-retrotransposon present in Drosophila melanogaster which shares similarities with vertebrates retroviruses both in its genomic arrangement and in the mechanism of transposition. Like in retroviruses, its two LTRs flank a long 5' untranslated region (5'UTR) and three open reading frames referred to as the gag, pol, and env genes. Here we report that its 5'UTR, located upstream of the gag gene, can fold into highly structured domains that are known to be incompatible with efficient translation by ribosome scanning. Using dicistronic plasmids analyzed by both (i) in vitro transcription and translation in rabbit reticulocyte or wheat germ lysates and (ii) in vivo expression in transgenic flies, we show that the 5'UTR of Idefix exhibits an internal ribosome entry site (IRES) activity that is able to promote translation of a downstream cistron in a cap-independent manner. The functional state of this novel IRES depends on eukaryotic factors that are independent of their host origin. However, in vivo, its function can be down-regulated by trans-acting factors specific to tissues or developmental stages of its host. We identify one of these trans-acting factors as the Gag protein encoded by Idefix itself. Our data support a model in which nascent Gag is able to block translation initiated from the viral mRNA and thus its own translation. These data highlight the fact that LTR-retrotransposons may autoregulate their replication cycle through their Gag production.
Molecular cloning and expression of SmIrV1, a Schistosoma mansoni antigen with similarity to calnexin, calreticulin, and OvRal1. (1993)

Protective immunity against schistosomiasis induced by vaccination of mice with irradiated cercaria can be passively transferred to uninfected mice with sera or IgG. Antigens that are uniquely or more strongly recognized by such protective sera compared with sera from infected unprotected mice have been identified previously. Two genes, SmIrV1 and SmIrV5, were selected from an adult worm cDNA library by screening with antibodies raised against these candidate vaccine proteins. Active immunization with the SmIrV5 protein induces high levels of protection in mice. We report here the molecular cloning and sequencing of SmIrV1 which contains a deduced amino acid sequence of 582 residues with similarity to three proteins: calnexin, calreticulin, and OvRal1, a surface antigen of the filarial nematode Onchocerca volvulus. SmIrV1 can be divided into three regions: a neutral N-terminal region with a putative signal sequence, followed by a proline- and tryptophan-rich P region in which two sets of sequences are repeated four times and a C-terminal region which is highly acidic with an isoelectric point of 4.7. We expressed the P and C regions of SmIrV1 and showed that this polypeptide reacts with sera of immunized as well as chronically infected mice.
Advanced zone simulation in Energyplus: Incorporation of variable properties and phase change material (PCM) capability (2007)

EnergyPlus models follow fundamental heat balance principles very closely in almost all aspects of the program. However, the simulation of building surface constructions has relied on a transfer function transformation carried over from BLAST. This has all the usual restrictions of a transformation-based solution: constant properties, and fixed values of some parameters. As the energy analysis field moves toward simulating more advanced constructions, such as phase change materials (PCM), it becomes necessary to step back from transformations to more fundamental forms. This paper describes the development of an implicit finite difference thermal model of building surfaces that has been incorporated into EnergyPlus. The model simulates the performance of PCM’s using an enthalpy or heat content formulation so energy accounting is accurate, and the phase change enthalpy is included fully. The model also permits modeling temperature dependent thermal conductivity. The complete multilayer construction capability of EnergyPlus is retained, so simulations can be done with the PCM in any location within the surface structure. Because of the short time steps used in the finite difference solution algorithm, the zone time step can be reduced to correspond with the one minute minimum time step used by the integrated system in EnergyPlus. Examples showing the effect of using PCM’s in various locations within a wall construction, and examples of the annual energy performance changes caused by such materials are presented.
Activation of AMPK Enhances Neutrophil Chemotaxis and Bacterial Killing (2013)

An inability of neutrophils to eliminate invading microorganisms is frequently associated with severe infection and may contribute to the high mortality rates associated with sepsis. In the present studies, we examined whether metformin and other 5' adenosine monophosphate-activated protein kinase (AMPK) activators affect neutrophil motility, phagocytosis and bacterial killing. We found that activation of AMPK enhanced neutrophil chemotaxis in vitro and in vivo, and also counteracted the inhibition of chemotaxis induced by exposure of neutrophils to lipopolysaccharide (LPS). In contrast, small interfering RNA (siRNA)-mediated knockdown of AMPKα1 or blockade of AMPK activation through treatment of neutrophils with the AMPK inhibitor compound C diminished neutrophil chemotaxis. In addition to their effects on chemotaxis, treatment of neutrophils with metformin or aminoimidazole carboxamide ribonucleotide (AICAR) improved phagocytosis and bacterial killing, including more efficient eradication of bacteria in a mouse model of peritonitis-induced sepsis. Immunocytochemistry showed that, in contrast to LPS, metformin or AICAR induced robust actin polymerization and distinct formation of neutrophil leading edges. Although LPS diminished AMPK phosphorylation, metformin or AICAR was able to partially decrease the effects of LPS/toll-like receptor 4 (TLR4) engagement on downstream signaling events, particularly LPS-induced IκBα degradation. The IκB kinase (IKK) inhibitor PS-1145 diminished IκBα degradation and also prevented LPS-induced inhibition of chemotaxis. These results suggest that AMPK activation with clinically approved agents, such as metformin, may facilitate bacterial eradication in sepsis and other inflammatory conditions associated with inhibition of neutrophil activation and chemotaxis.