gebhart/patrepeval huggingface dataset:
Genome and metagenome sequencing: Using the human methyl‐binding domain to partition genomic DNA derived from plant tissues (2014)

The application of MBD2 enabled fractionation of plant gDNA. The effectiveness was particularly striking for monocot gDNA (Poaceae). When sufficiently effective on a sample, this approach can increase the cost efficiency of sequencing plant genomes as well as prokaryotes living in or on plant tissues.
Liquid crystals, photonic crystals, metamaterials, and transformation optics (2011)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Effect of caesalpina sappan L. and lithospermum erythrorhizon extract mixture and crab shell on the fermentation of kimchi (1999)

The studies were carried out to investigate antimicrobial activity of mixture of Caesalpina sappan L. and Lithospermum erythrorhizon extracts against lactic acid bacteria isolated from Kimchi. The effects of the mixture and crab shell extracts on the shelf-life of Kimchi were also investigated. The growth of heterofermentative lactic acid bacteria and homofermentative lactic acid bacteria was inhibited by 98% ethanol extracts of Caesalpina sappan L. and Lithospermum erythrorhizon. The pH of Kimchi containing mixed extracts of Caesalpina sappan L. and Lithospermum erythrorhizon extracts (1 : 1) and crab shell was lower than that of control during fermentation for 25 days of . The viable cells of Lactic acid bacteria of the mixed extracts and crab shell added Kimchi were lower than that of control during fermentation. The sensory quality of the mixed extracts and Crab shell added Kimchi was a little inferior to control for during fermentation of Kimchi.
Current status of rapidly solidified Nd-Fe-B permanent magnets (1989)

Nd-Fe-B alloys can be rapidly solidified to produce a highly stable, magnetically isotropic powder which can be processed directly into either bonded magnets or, if not pressed, into anisotropic magnets with energy levels exceeding 40 MGOe. Current processing methods are briefly reviewed, as are some of the unique advantages that these materials offer as a result of their extremely fine-grained microstructure. Development issues concerning these materials are discussed, including activities aimed at improving thermal performance, magnetic uniformity, and manufacturability of hot deformed materials. The status of and outlook for using anisotropic powders from ground hot-deformed materials are examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On Combining Multiple Segmentations in Scene Text Recognition (2013)

An end-to-end real-time scene text localization and recognition method is presented. The three main novel features are: (i) keeping multiple segmentations of each character until the very last stage of the processing when the context of each character in a text line is known, (ii) an efficient algorithm for selection of character segmentations minimizing a global criterion, and (iii) showing that, despite using theoretically scale-invariant methods, operating on a coarse Gaussian scale space pyramid yields improved results as many typographical artifacts are eliminated. The method runs in real time and achieves state-of-the-art text localization results on the ICDAR 2011 Robust Reading dataset. Results are also reported for end-to-end text recognition on the ICDAR 2011 dataset.
Modify, enhance, select: co-evolution of combinatorial models and test plans (2018)

The evolution of software introduces many challenges to its testing. Considerable test maintenance efforts are dedicated to the adaptation of the tests to the changing software. As a result, over time, the test repository may inflate and drift away from an optimal test plan for the software version at hand. Combinatorial Testing (CT) is a well-known test design technique to achieve a small and effective test plan. It requires a manual definition of the test space in the form of a combinatorial model, and then automatically generates a test plan design, which maximizes the added value of each of the tests. CT is considered a best practice, however its applicability to evolving software is hardly explored.
The leak stops here: platelets as delivery vehicles for coagulation factors (2006)

Gene therapy is an attractive approach for the treatment of hemophilia, as continuous expression of donated clotting factor VIII (FVIII) DNA would ensure clotting factor replacement at constant circulating levels rather than at the peaks and troughs that characterize the current protein infusion therapeutic approach. In this issue of the JCI, Shi et al. describe an interesting variant of a gene transfer approach for hemophilia (see the related article beginning on page 1974). They show that targeted expression of FVIII in megakaryocytes, with storage in the alpha-granules of platelets, has the advantage of delivering clotting factors directly to the site of an injury, where platelets accumulate in large numbers and undergo activation accompanied by release of granule contents. Earlier clinical experience with gene transfer into hematopoietic cells highlighted the potential safety risks of this approach, but an F8 transgene may represent a lower risk than transgenes for growth factors or their receptors.
Edema from intracerebral hemorrhage: the role of thrombin (1996)

The mechanism by which intracerebral hemorrhage leads to the formation of brain edema is unknown. This study assesses the components of blood to determine if any are toxic to surrounding brain. Various solutions were infused stereotactically into the right basal ganglia of rats. The animals were sacrificed 24 hours later; brain edema and ion contents were measured. Whole blood caused an increase in brain water content and ion changes consistent with brain edema. Concentrated blood cells, serum from clotted blood, and plasma from unclotted blood all failed to provoke edema formation when infused directly into the brain. On the other hand, activation of the coagulation cascade by adding prothrombinase to plasma did produce brain edema. The edema response to whole blood could be prevented by adding a specific thrombin inhibitor, hirudin, to the injected blood. This study indicates that thrombin plays an important role in edema formation from an intracerebral blood clot.
PAS: A Wireless-Enabled, Sensor-Integrated Personal Assistance System for Independent and Assisted Living (2007)

Advances in networking, sensors, and embedded devices have made it feasible to monitor and provide medical and other assistance to people in their homes. Aging populations will benefit from reduced costs and improved healthcare through assisted living based on these technologies. However, these systems challenge current state-of-the-art techniques for usability, reliability, and security. In this paper we present the PAS open architecture for assisted living, which allows independently developed third party components to collaborate. We discuss key technological issues in assisted living systems, such as tracking, fall detection, security and privacy; and results from our pilot study in a real assisted living facility are presented.
[Effect of plasmapheresis with substitution by dextran solutions on hemostatic parameters in patients with ischemic heart disease]. (1991)

Plasmapheresis on a continuous blood flow fractionator to remove 1,200-2,000 ml plasma and substitute for the same values of dextran solutions was employed in the multi-modality treatment of 25 patients with Functional Classes II-IV exertional angina and myocardial infarction. Plasma and thrombocyte hemostatic parameters were examined just before and 24 and 48 hours after plasmapheresis. The analysis of the baseline data revealed that hemostatic changes were directly related to the severity of a disease in the patients and there was a correlation between the increased platelet aggregability and the elevated levels of fibrin-monomeric complexes. Plasmapheresis along with substitution of removed plasma for dextran solutions was accompanied by a profound hypocoagulative effect, as evidenced by plasma and thrombocyte hemostatic parameters. In addition, in patients with baseline high values of platelet aggregability plasmapheresis resulted in its decrease, whereas in those with baseline low values, it led to its increase.
Synthesis, Anti-HIV Activity, and Molecular Mechanism of Drug Resistance of <scp>l</scp>-2‘,3‘-Didehydro-2‘,3‘-dideoxy-2‘-fluoro-4‘-thionucleosides (2002)

beta-l-2',3'-Didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides (beta-l-2'-F-4'-S-d4Ns) have been synthesized and evaluated against HIV-1 in primary human lymphocytes. The key intermediate 8, which was prepared from 2,3-O-isopropylidene-l-glyceraldehyde 1 in 13 steps, was condensed with various pyrimidine and purine bases followed by elimination and deprotection to give the target compounds, beta-l-2'-F-4'-S-d4Ns (17-20 and 27-30). The antiviral activity of the newly synthesized compounds was evaluated against HIV-1 in human peripheral blood mononuclear (PBM) cells, among which the cytosine 17, 5-fluorocytosine 18, and adenine 27 derivatives showed potent anti-HIV activities (EC(50) = 0.12, 0.15, and 1.74 microM, respectively) without significant cytotoxicity up to 100 microM in human PBM, CEM, and Vero cells. The cytosine derivative 17 (beta-l-2'-F-4'-S-d4C), however, showed cross-resistance to a 3TC-resistant variant (HIV-1(M184V)). Molecular modeling studies suggest that the pattern of antiviral activity, similar to that of beta-l-2'-F-d4N, stemmed from their conformational and structural similarities. The isosteric substitution of sulfur for 4'-oxygen was well tolerated in the catalytic site of HIV-1 reverse transcriptase in the wild-type virus. However, the steric hindrance between the sugar moiety of the unnatural l-nucleoside and the side chains of Val184 of M184V RT in 3TC-resistant mutant HIV strains destabilizes the RT-nucleoside triphosphate complex, which causes the cross-resistance to 3TC (M184V mutant).
Trabectedin and its potential in the treatment of soft tissue sarcoma (2008)

Trabectedin is a new marine-derived compound that binds the DNA minor groove and interacts with proteins of the DNA repair machinery. Phase I trials have established the standard regimen as 1500 mug/m(2) 24-hour continuous infusion repeated every 3 weeks. Several phase II trials have shown response in 5%-10% of unselected patients with soft tissue sarcoma failing prior chemotherapy and disease stabilisation in 30%-40%. Furthermore, prolonged disease control has been described in 15%-20% of patients. Toxicities are mainly haematological and hepatic with grade 3-4 neutropenia and thrombocytopenia observed in approximately 50% and 20% of patients respectively, and grade 3-4 elevation of liver enzymes observed in 35%-50% of patients treated with trabectedin. Current research focuses on the identification of predictive factors for patients with soft tissue sarcoma treated with trabectedin.
Solvate Formation by Certain Tetrahalides in Liquid Sulfur Dioxide (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvate Formation by Certain Tetrahalides in Liquid Sulfur DioxideP. A. Bond and Wm. E. BeltonCite this: J. Am. Chem. Soc. 1945, 67, 10, 1691–1693Publication Date (Print):October 1, 1945Publication History Published online1 May 2002Published inissue 1 October 1945https://pubs.acs.org/doi/10.1021/ja01226a023https://doi.org/10.1021/ja01226a023research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Subunit Structure of the Erythropoietin Receptor (1989)

Chemical cross-linking of the red blood cell hormone, erythropoietin (Epo), to its receptor on erythroid cells has revealed the presence of two proteins closely associated with Epo, but the relationship between these two proteins is controversial. Using the cross-linking reagents disuccinimidyl suberate and dithiobissuccinimidyl propionate, we show that 125I-Epo can be specifically conjugated in a complex of 224kDa using mouse fetal liver cells, bone marrow cells, and Friend virus-induced splenic erythroblasts as demonstrated by electrophoresis on sodium dodecyl sulfate-polyacrylamide gels under nonreducing conditions. Under reducing conditions, the 224-kDa complex appeared as two Epo conjugates of 136 kDa and 119 kDa, and these bands were also observed to a variable extent in some nonreducing gels. Disulfide linking of the 136-kDa and 119-kDa bands was confirmed by two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis run under nonreducing followed by reducing conditions. With increasing time of 125I-Epo binding to Friend virus erythroblasts in the presence of sodium azide to inhibit receptor internalization, the 136-kDa and 119-kDa bands seen under reducing conditions increased markedly in intensity, whereas the 224-kDa band seen under nonreducing conditions declined. These results suggest that the 224-kDa Epo conjugate is inefficiently solubilized under nonreducing conditions following prolonged periods of Epo binding. A single class of saturable, high affinity receptors for Epo on each of the cell types tested is demonstrated. It is concluded that the two disulfide-linked Epo-binding proteins which can be independently cross-linked to Epo form a single ligand binding site.
Identification and Characterization of Melanotropin Binding Proteins from M2R Melanoma Cells by Covalent Photoaffinity Labeling* (1988)

In this study, two melanotropin binding proteins from M2R melanoma cells have been identified based on the photochemical cross-linking of [125I]iodinated porcine beta-MSH ([ 125I]iodo-beta-MSH) to melanoma cell membranes, using N-hydroxysuccinimidyl-azidobenzoate. Autoradiography of photoaffinity-labeled M2R membrane protein, after sodium dodecyl sulfate-polyacrylamide gel electrophoresis, revealed the specific labeling of two separate bands with an apparent molecular mass of 43 and 46 kilodaltons, respectively. Photoaffinity labeling of both bands was of near-equal intensity and could be inhibited, in a dose-dependent manner, by the addition of unlabeled beta-MSH before photolysis. In addition, agents known to inhibit the binding of beta-MSH to its cellular receptor, such as EGTA, GTP, guanosine 5'-O-(3-thio)triphosphate, and a synthetic analog of the calmodulin-binding domain of myosin light chain kinase-M5, were all found to specifically inhibit the labeling of these two protein bands by the azido derivative of [125I]iodo-beta-MSH. In contrast, addition of a nonrelated peptide, vasoactive intestinal peptide, had no effect upon the labeling of these melanotropin-binding proteins. On the basis of these results we suggest that the two proteins may function as the binding domain(s) of the cellular receptor for melanotropins, or may represent entire receptor moieties themselves.
Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis (2009)

Depression and CRP, IL-1, and IL-6 are positively associated in clinical and community samples and BMI is implicated as a mediating/moderating factor. Continuity in clinic- and community-based samples suggests there is a dose-response relationship between depression and these inflammatory markers, lending strength to the contention that the cardiac (or cancer) risk conferred by depression is not exclusive to patient populations. Available evidence is consistent with three causal pathways: depression to inflammation, inflammation to depression, and bidirectional relationships.
Constraint based analysis tools for design (1993)

Finite element analysis has become a powerfid tool in the design process. Analyses of stress, heat transfer and dynamic behavior are common to ftite element analysis. Due to the time required to build a ftite element model, finite element analysis is tx%g used as an atter-the-fact verification tool. This fact prevents the use of the FEA in the early design stages. This paper &scribes an interactive constraint based system developed at University of Puerto Rico for finite element model generation, solution and optimization using 3D elements. The system consists of a geome~editor, constraint generator, constraint solver, fmalysis file generator and optimizer. ANSYS~is used as the Finite Element engine. This system has been designed for modeling 3D shapes from which a finite element model is derived, solved and optimized.
INVESTIGATION OF PHASE TRANSITION MECHANISM IN VANADIUM OXIDE THIN FILMS (2003)

Thin film materials with &quot;smart &quot; properties which react with temperature variations, electrical or magnetic fields, and pressure variations, attracted great attention in recent years. Vanadium dioxide thin films belong to this family of &quot;smart materials &quot; by having a first order phase transition metal-semiconductor. These films display a variety of conductivities under heating in the vicinity of Curie temperature. The electrical properties of vanadium dioxide films were studied in past and found to be outstanding. This paper deals with the electrical properties of specific vanadium oxide thin films, deposited on various substrates. We have been able to show that the electrical transport mechanism of the obtained vanadium oxide films differs in low and high electrical fields. In low electrical fields, conductivity is obtained by Schottky transport mechanism, whereas in high electrical fields conductivity ranges from Ohmic mechanism for low fields to Poole-Frenkel for higher fields.
Expression profile of CREB knockdown in myeloid leukemia cells (2008)

We have identified a high confidence list of CREB targets in K562 cells. These genes allow us to begin to understand the mechanisms by which CREB contributes to acute leukemia. We speculate that regulation of histone genes may play an important role by possibly altering the regulation of DNA replication during the cell cycle.
Surface Modification for Adhesion (1990)

<div class="htmlview paragraph">Since the best route to adhesion is through chemical bonding, the knowledge of which of the chemical groups present on the surface of a plastic lead to good adhesion is essential for defining the proper paint/plastic combination. To answer this question we studied corona and UV surface modification of several engineering resins, and its effect on the adhesion of a two component polyurethane paint. In every case such surface modification led to a substantial improvement in adhesion. To determine which functional groups were responsible for this improvement, plasma polymerizations on the neat resins were carried out in an attempt to produce a specifically functionalized surface. The amount of the given functional group within the plasma polymerized films was measured by XPS. From this information and the amount of paint adhesion to these plasma modified surfaces it was concluded that the -OH and possibly -CHO groups are most desirable in promoting adhesion to the two component polyurethane paint.</div>
Evaluation of arterial oxygen saturation using RGB camera-based remote photoplethysmography (2018)

Plethysmogram is the periodic variation in blood volume due to the cardiac pulse traveling through the body. Photo-plethysmograph (PPG) has been widely used to assess the cardiovascular system such as heart rate, blood pressure, cardiac output, vascular compliance. We have previously proposed a non-contact PPG imaging method using a digital red-green-blue camera. In the method, the Monte Carlo simulation for light transport is used to specify a relationship among the <i>RGB</i>-values and the concentrations of oxygenated hemoglobin (<i>C<sub>HbO</sub></i>) and deoxygenated hemoglobin (<i>C<sub>HbR</sub></i>). The total hemoglobin concentration (<i>C<sub>HbT</sub></i>) can be calculated as a sum of <i>C<sub>HbO</sub></i> and <i>C<sub>HbR</sub></i>. Applying the fast Fourier transform (FFT) band pass filters to each pixel of the sequential images for <i>C<sub>HbT</sub></i> along the time line, two-dimentional plethysmogram can be reconstructed. In this study, we further extend the method to imaging the arterial oxygen saturation (<i>SaO</i><sub>2</sub>). The PPG signals for both <i>C<sub>HbO</sub></i> and <i>C<sub>HbR</sub></i> are extracted by the FFT band pass filter and the pulse wave amplitudes (PWAs) of <i>C<sub>HbO</sub></i> and <i>C<sub>HbR</sub></i> are calculated. We assume that the PWA for <i>C<sub>HbO</sub></i> and that for CHbR are decreased and increased as SaO<sub>2</sub> is decreased. The ratio of PWA for <i>C<sub>HbO</sub></i> and that for <i>C<sub>HbR</sub></i> are associated to the reference value of <i>SaO</i><sub>2</sub> measured by a commercially available pulse oximeter, which provide an empirical formula to estimate SaO<sub>2</sub> from the PPG signal at each pixel of RGB image. <i>In vivo</i> animal experiments with rats during varying the fraction of inspired oxygen (FiO<sub>2</sub>) demonstrated the feasibility of the proposed method.