gebhart/patrepeval huggingface dataset:
Fat embolism in hemoglobin SC disease: A case report with brief review of the literature (2017)

Fat embolism is a known complication of bone marrow infarction in patients with sickle cell disease (hemoglobin SS and hemoglobin SC disease). We report a case of a 36-year-old woman with hemoglobin SC disease who presented with headache, nausea, and photophobia. The patient experienced hypoxic respiratory failure, anemia and thrombocytopenia and expired four days later. Postmortem examination revealed fat emboli in the lungs and brain. Although uncommon, fat embolism syndrome should be considered in the differential diagnosis of acute complications with hemoglobin SC disease. Keywords: Fat embolism syndrome, Hemoglobin SC disease, Sickle cell disease, Oil Red O stains
Circuits and Systems for Wireless Body Area Network (2016)

This chapter focuses on the implementation of the "Things"-oriented medical body area network (MBAN) system which sheds new light on the short-range connectivity among various physiological sensors and wearable devices carried by human bodies for a continuous and ambulatory connection. It describes an energy-efficient MBAN system for mobile healthcare applications that has been implemented with crystal-less compact wearable and implantable sensor nodes. With regard to the MBAN sensor nodes, energy-efficient wireless technologies are a major design challenge that will extend the lifetime of the nodes under limited energy sources. The frequency calibration method utilized effectively eliminates the crystal oscillator (XO) in the sensor nodes with the help of the reference signal from the hub. The low power circuit techniques for the sensors and hub transceiver were introduced in our previous research. The prototype MBAN system was implemented to verify the proposed system, and the successful measurement results were provided.
The expanding role of mouse genetics for understanding human biology and disease (2008)

It has taken about 100 years since the mouse first captured our imagination as an intriguing animal for it to become the premier genetic model organism. An expanding repertoire of genetic technology, together with sequencing of the genome and biological conservation, place the mouse at the foremost position as a model to decipher mechanisms underlying biological and disease processes. The combined approaches of embryonic stem cell-based technologies, chemical and insertional mutagenesis have enabled the systematic interrogation of the mouse genome with the aim of creating, for the first time, a library of mutants in which every gene is disrupted. The hope is that phenotyping the mutants will reveal novel and interesting phenotypes that correlate with genes, to define the first functional map of a mammalian genome. This new milestone will have a great impact on our understanding of mammalian biology, and could significantly change the future of medical diagnosis and therapeutic development, where databases can be queried in silico for potential drug targets or underlying genetic causes of illnesses. Emerging innovative genetic strategies, such as somatic genetics, modifier screens and humanized mice, in combination with whole-genome mutagenesis will dramatically broaden the utility of the mouse. More significantly, allowing genome-wide genetic interrogations in the laboratory, will liberate the creativity of individual investigators and transform the mouse as a model for making original discoveries and establishing novel paradigms for understanding human biology and disease.
Corrections for Dead-Time Losses in the Measurement of Gamma-Ray Spectra of Short-Lived Radionuclides (1971)

Multichannel analyzers are necessary tools in activation analysis. The reliability of the analytical results depends on the correction for dead time. When measuring long-lived radionuclides, this correction is automatically applied in all modern instruments by lengthening the counting time. This procedure is not sufficient in the case of short-lived species. A residual error will remain. The correction to be applied depends on the total dead time at the beginning of the measurement and on the ratio preset time/half-life. The first quantity can be read from the analyzer.
<font>Li</font>-DOPING EFFECT ON THE CATHODOLUMINESCENT PROPERTIES OF <font>Y</font><sub>2</sub><font>O</font><sub>3</sub>:<font>Eu</font><sup>3+</sup> PHOSPHORS (2007)

Influence of lithium doping on the crystallization, the surface morphology, the chemical states and the luminescent properties of Y 2 O 3 : Eu 3+ phosphors was investigated. The structural, surface morphology characteristics and chemical states of the phosphors were analyzed by using X-ray diffraction (XRD), scanning electron microscope (SEM), and X-ray photoelectron spectroscopy (XPS), respectively. The crystallinity, the surface morphology, and the cathodoluminescence (CL) of phosphors highly depended on the Li doping. The relationship between the crystalline and morphological structures and the luminescent properties was studied, and Li + doping affected not only the crystallinity but also the luminescent brightness of Y 2 O 3 : Eu 3+ phosphors. In particular, the incorporation of the Li + ion into the Y 2 O 3 lattice could induce remarkable increase in the CL intensity. The enhanced photoluminescence brightness with Li doping may result both from the improved crystallinity leading to higher oscillating strengths for the optical transitions, and the increased surface area due to the larger particle sizes. The strongest emission intensity was observed with Li doped Y 2 O 3 : Eu 3+ ceramics whose brightness was increased by a factor of 1.8 in comparison with that of Y 2 O 3 : Eu 3+ ceramics.
New self-adaptative algorithms for source separation based on contrast functions (2002)

Introduces self-adaptive algorithms for source separation based on a generalized criterion with the introduction of cross-cumulants. By adequate adaptive preprocessing it can be supposed that the observed source mixture x is 'white'. Then a separating matrix H (such that y=Hx has independent components) can be assumed unitary. A new contrast function is defined whose maximum occurs when H is separating. Its (simple) form admits an associated adaptive algorithm. Two different algorithms are proposed to estimate H, either directly or through its equivalent product of Givens rotations. Computer simulations illustrate the contribution of the cross-cumulants on the convergence of the algorithms. In the three-sources case, they show that the performances are improved substantially.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Writing, supporting, and evaluating tripwire: a publically available security tool (1994)

Tripwire is an integrity checking program written for the Unix environment that gives system administrators the ability to monitor file systems for added, deleted, and modified files. First released in November of 1992, Tripwire has undergone several updates and is in current use at thousands of machines worldwide. This paper begins with a brief overview of what Tripwire does and how it works. We discuss how certain implementation decisions affected the course of Tripwire development. We also present other applications that have been found for Tripwire. These unanticipated uses guided the demands of some users, and we describe how we addressed some of these demands without compromising the ability of Tripwire to serve as a useful security tool. We also discuss the process of releasing, and then supporting, a widely available and widely used tool across the Internet, and how meeting users&apos; high expectations affects this process. How these issues affected Tripwire, done as as an independent study by an undergraduate, is also discussed. Software tools that were used in developing and maintaining Tripwire are presented. Finally, we discuss problems that remain unresolved and some possible solutions.
Two mechanisms of iron uptake from transferrin by melanoma cells. The effect of desferrioxamine and ferric ammonium citrate. (1992)

The effects of ferric ammonium citrate (FAC) and desferrioxamine (DFO) on iron (Fe), and transferrin (Tf) uptake have been investigated using SK-MEL-28 human melanoma cells, which express the Tf homologue, melanotransferrin, in high concentrations. Previously we demonstrated two separate Fe uptake mechanisms from Tf, viz. a specific process mediated by the transferrin receptor (TfR) and a nonspecific process (Richardson, D. R., and Baker, E. (1990) Biochim. Biophys. Acta 1053, 1-12). Cells exposed to DFO demonstrated up-regulation of the TfR with a concurrent increase in the rate of Fe uptake. Desferrioxamine also stimulated the nonspecific process of Fe uptake, resulting in a further increase in accumulation of Fe over Tf after saturation of the specific TfR. Ferric ammonium citrate had two effects. First, it resulted in down-regulation of the TfR. Second, and paradoxically, it markedly stimulated the rate of Fe uptake from Tf by the nonspecific process without increasing the rate of nonspecific Tf uptake. These data conclusively demonstrate that two entirely different mechanisms of iron uptake from Tf exist in melanoma cells and that ferric ammonium citrate may be a useful experimental tool to further characterize the specific and nonspecific mechanisms of Fe uptake from Tf.
Cleavage of dengue virus NS1-NS2A requires an octapeptide sequence at the C terminus of NS1 (1990)

The length of amino acid sequence at the NS1-NS2A juncture of dengue virus that is required for specific cleavage effected by the cis-acting function of NS2A was identified by deletion analysis. Recombinant DNA sequences of NS1-NS2A, each containing a deletion in NS1 followed by a sequence of 3 to 20 amino acids at the C terminus of NS1 preceding the cleavage site, were constructed and expressed with vaccinia virus as a vector. The NS1 product of recombinant vaccinia virus-infected cells was immunoprecipitated and analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The occurrence of cleavage between NS1 and NS2A was indicated by the appearance of shortened NS1. Failure to cleave this site yielded a large NS1-NS2A fusion protein. This analysis indicated that a minimum length of eight amino acids at the NS1 C terminus preceding the NS1-NS2A juncture is required for cleavage to take place. Comparison of this eight-amino-acid sequence of the NS1 C terminus of dengue type 4 virus with the analogous sequences of 12 other flaviviruses suggests that the consensus cleavage site sequence is as follows: (table; see text)
Corporate Reporting in the Target Design of the Entrepreneurship System (2019)

Aim of study: Modern concepts related to preparation of integrated corporate reporting, as one of areas of development of accounting and a new approach to organization and management of accounting and financial business processes with integration of financial and non-financial information required by a wide range of stakeholders, has recently received increased attention. Methodology. A factor development of knowledge field of information integration, formation of integrated corporate reporting was transition of Russia from industrial economy to digital, which provides for the formation of information space, taking into account needs of citizens and society obtaining quality and reliable information» ; creation of an economic system, data of which in digital form are key factor of production all spheres of social and economic activity, and provide effective interaction of business, scientific and educational community, state and citizens. Conclusion: The concept of development of public non-financial reporting and action plan for its implementation, which recognized high importance of non-financial reporting modern economic conditions.
Performance evaluation of Network on Chip architectures (2009)

A new chip design paradigm Network on Chip (NOC), proposed by many research groups is an important architectural choice for future SOCs. Various proposed Network on Chip (NoC) architecture attempts to address different component level architectures with specific interconnection network topologies and routing techniques, some of the topologies are CLICHE, Folded Torus, BFT, SPIN and Octagon. This research work compares proposed NoC architectures and to evaluate their performance using a simulating tool NS-2. Simulation provides relationship among latency, throughput and packet drop probability for NoC architectures.
Differential Modulation of Mitogen-activated Protein (MAP) Kinase/Extracellular Signal-related Kinase Kinase and MAP Kinase Activities by a Mutant Epidermal Growth Factor Receptor (1995)

A paradigm has been established whereby mutant tyrosine kinase receptors such as the v-erbB and v-fms gene products function as oncoproteins in the absence of ligand. A spontaneously occurring deletional mutant of the human epidermal growth factor receptor (EGFR-vIII) has been isolated from astrocytic neoplasms and transforms NIH3T3 cells in the absence of ligand. The EGFRvIII is constitutively complexed with the majority of cellular GRB2, suggesting a link to the Ras-Mitogen-activated protein (MAP) kinase pathway (D. Moscatello, R. B. Montgomery, P. Sundareshan, H. McDanel, M. Y. Wong, and A. J. Wong, submitted for publication). In this report, we document that expression of EGFRvIII in fibroblasts is associated with downstream activation of mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase (MEK) and modest activation of p42 and p44 MAP kinases. The presence of EGFRvIII suppresses activation of p42 and p44 MAP kinases by phorbol 12-myristate 13-acetate (PMA) and serum; however, MEK activation by PMA is not suppressed by EGFRvIII. Basal and PMA-stimulated MAP kinase activity in EGFRvIII-transfected cells is augmented by the tyrosine phosphatase inhibitor sodium vanadate. EGFR-vIII is capable of transducing downstream signals through MAP kinase as evidenced by activation of cytoplasmic phospholipase A2 at levels similar to that induced by intact EGFR. Our results suggest that EGFR-vIII constitutively activates downstream signal transduction through MAP kinase, and this chronic stimulation of the MAP kinase pathway may represent one means by which mutant EGFR transduces an oncogenic signal.
Research on correcting algorithm of QR code image's distortion (2017)

In order to accurately recognize the QR code information, it is necessary to correct the QR code image precisely. To improve the recognition's accuracy of QR code, this paper presents an algorithm to correct the distortion of QR code image precisely. Based on the traditional geometric correction, the algorithm finds the black and white data block by finding the position where the variance is the smallest in the region, using the variance of the pixel in the fixed region and the degree of gray value. The judged black and white block information is placed in a new matrix, and the QR code binary image is restored accurately. The algorithm can not only correct the general image distortion, but also solve the problem of image cylindrical distortion and QR code information's extraction.
Effects of multispectral excitation on the sensitivity of molecular optoacoustic imaging (2014)

Molecular optoacoustic (photoacoustic) imaging typically relies on the spectral identification of absorption signatures from molecules of interest. To achieve this, two or more excitation wavelengths are employed to sequentially illuminate tissue. Due to depth-related spectral dependencies and detection related effects, the multispectral optoacoustic tomography (MSOT) spectral unmixing problem presents a complex non-linear inversion operation. So far, different studies have showcased the spectral capacity of optoacoustic imaging, without however relating the performance achieved to the number of wavelengths employed. Overall, the dependence of the sensitivity and accuracy of optoacoustic imaging as a function of the number of illumination wavelengths has not been so far comprehensively studied. In this paper we study the impact of the number of excitation wavelengths employed on the sensitivity and accuracy achieved by molecular optoacoustic tomography. We present a quantitative analysis, based on synthetic MSOT datasets and observe a trend of sensitivity increase for up to 20 wavelengths. Importantly we quantify this relation and demonstrate an up to an order of magnitude sensitivity increase of multi-wavelength illumination vs. single or dual wavelength optoacoustic imaging. Examples from experimental animal studies are finally utilized to support the findings. In vivo MSOT imaging of a mouse brain bearing a tumor that is expressing a near-infrared fluorescent protein. (a) Monochromatic optoacoustic imaging at the peak excitation wavelength of the fluorescent protein. (b) Overlay of the detected bio-distribution of the protein (red pseudocolor) on the monochromatic optoacoustic image. (c) Ex vivo validation by means of cryoslicing fluorescence imaging.
ANTICANCER DRUG: Boost to taxol supply planned (1992)

RETURN TO ISSUEPREVNewsNEXTANTICANCER DRUG: Boost to taxol supply plannedSTU BORMANCite this: Chem. Eng. News 1992, 70, 10, 4Publication Date (Print):March 9, 1992Publication History Published online10 November 2010Published inissue 9 March 1992https://pubs.acs.org/doi/10.1021/cen-v070n010.p004https://doi.org/10.1021/cen-v070n010.p004newsACS PublicationsCopyright © 1992 American Chemical SocietyArticle Views7Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Cancer Get e-Alerts
Network Delay Tomography using Flexicast Experiments (2006)

Summary Estimating and monitoring the quality of service of computer and communications networks is a problem of considerable interest. The paper focuses on estimating link level delay distributions from end-to-end path level data collected by using active probing experiments. This is an interesting large scale statistical inverse (deconvolution) problem. We describe a flexible class of probing experiments (‘flexicast’) for data collection and develop conditions under which the link level delay distributions are identifiable. Maximum likelihood estimation using the EM algorithm is studied. It does not scale well for large trees, so a faster algorithm based on solving for local maximum likehood estimators and combining their information is proposed. The usefulness of the methods is illustrated on real voice over Internet protocol data that were collected from the University of North Carolina campus network.
Direct posterior confidence for out-of-vocabulary spoken term detection (2012)

Spoken term detection (STD) is a key technology for spoken information retrieval. As compared to the conventional speech transcription and keyword spotting, STD is an open-vocabulary task and has to address out-of-vocabulary (OOV) terms. Approaches based on subword units, for example phones, are widely used to solve the OOV issue; however, performance on OOV terms is still substantially inferior to that of in-vocabulary (INV) terms. The performance degradation on OOV terms can be attributed to a multitude of factors. One particular factor we address in this article is the unreliable confidence estimation caused by weak acoustic and language modeling due to the absence of OOV terms in the training corpora. We propose a direct posterior confidence derived from a discriminative model, such as multilayer perceptron (MLP). The new confidence considers a wide-range acoustic context which is usually important for speech recognition and retrieval; moreover, it localizes on detected speech segments and therefore avoids the impact of long-span word context which is usually unreliable for OOV term detection. In this article, we first develop an extensive discussion about the modeling weakness problem associated with OOV terms, and then propose our approach to address this problem based on direct poster confidence. Our experiments carried out on spontaneous and conversational multiparty meeting speech, demonstrate that the proposed technique provides a significant improvement in STD performance as compared to conventional lattice-based confidence, in particular for OOV terms. Furthermore, the new confidence estimation approach is fused with other advanced techniques for OOV treatment, such as stochastic pronunciation modeling and discriminative confidence normalization. This leads to an integrated solution for OOV term detection that results in a large performance improvement.
Mitigation of GX209HA Processor for Usage in Space (2016)

This thesis aim to create rtl hardware to control the boot up of the commercial AMD GX209HA SOC processor. During this thesis the decision was made to boot GX209HA from a fault tolerant external memory over the SPI and use the LPC bus to control that the processor booted correctly. The SPI was created to emulate the PCT25VF032B SPI ash memory and a FIFO register was attached to the SPI to store the data before it is being transmitted. To communicate with the main system an interface to the internal wishbone bus was created for this hardware. The last piece of hardware to be created was the LPC interface and the FIFO that will store the test codes from the BIOS of he processor. The created hardware functioned properly during simulation and the SPI interface work for a linear transfer. However, the GX209HA processor start executing the instructions while the boot image is being transferred and will jump between addresses. The LPC interface receives one test code before it get stuck, which has not been solved. Thermal interface materials has been investigated and a list of thermal interface materials that pass the ESA outgassing restrictions has been constructed.
The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets – improving meta-analysis and prediction of prognosis (2008)

Multiplicative, systematic biases are introduced at many stages of microarray experiments. When these are reconciled, raw data can be directly integrated from different gene expression datasets leading to new biological findings with increased statistical power.