gebhart/patrepeval huggingface dataset:
A six-port interferometer based micrometer-accuracy displacement and vibration measurement radar (2012)

Displacement detection and vibration measurements are important requirements for automation and mechanical stress diagnosis in diverse industrial environments. Laser interferometry is a widely used technique for these kinds of measurements since it features high-resolution, wide dynamic range and wide frequency response. Another advantage of the laser interferometry technique is contactless diagnosis/sensing which allows remote operations. However this technique is not suitable in harsh environments for instance with the presence of dust or fog which occur in several industrial production sites. In this paper a new contactless radar based vibration measurement technique is presented. It features an RF frontend based on a passive six-port interferometer working at 24 GHz. A dedicated signal processing unit is also presented. The proposed hardware allows to measure with a position accuracy of 0.5 µm.
Determinants of State Institutions Performance in Sierra Leone (2021)

Public institutions performance has been the greatest concern for governments in different parts of the world. In Sierra Leone, the success of governments departments contribute towards the socio economic development of the country. Nevertheless, achieving exceptional performance in public institutions is encircled with enormous challenges that hinders the achievement of strategic objectives. Considering the quantum challenges surrounding public institutions performance, addressing those challenges requires consideration of numerous elements that could influence performance. However, this study focus on determinants of state institutions performance in Sierra Leone. The investigation started with an assessment of previous and existing performance benchmarks and then proceeded to its focus. This study was conducted in Freetown, using three public institutions as sample frame and obtained a sample size of 300 employees in a random manner, ranging from nonsupervisory to managerial level. We employed primary data collection method, using the Linkert scale system, which shows the following description: 5=Strongly Agree, 4=Agree, 3=Neutral, 2=Disagree, 1=Strongly Disagree. The study analysed primary data with descriptive statistics and correlational methods aided by SPSS 21. Data obtained from respondents shows that human capital development, rewards, effective and efficient administrative structure and personnel engagement determines state institutions performance. Respondents noted that if state institutions have efficient administrative structure, they would facilitate human capital development and empowerment, ensure efficient management of financial resources and engage personnel for effective job performance. The aforementioned elements constitute determinants of exceptional performance. This study is therefore noteworthy to performance management specialists, human capital enhancement professionals and public institutions in Sierra Leone.
Design of USB FM Receiver Based on TEA5767 System (2010)

以TEA5767调频收音芯片和C8051F320微控制器为基础,结合USB通信技术,完成了调频收音机的设计.该调频收音机将收音芯片接收到的声音信号进行处理和数字化,通过USB接口将数字声音数据上传给上位机,任何具有USB连结功能的Windows个人计算机或笔记本电脑,只要通过USB接口连接本设计,就能通过计算机扬声器播放调频广播音频.
Conference Report and Review: Current Status of Biomarkers Potentially Associated With Prostate Cancer Outcomes (2007)

Several ongoing and planned adjuvant prostate cancer trials will provide a tremendous opportunity for biological sample collection along with the potential to validate many biomarkers. Practicing urologists have an opportunity to have a critical role in the successful accrual of patients into these trials.
Order Independence for Iterated Weak Dominance (1997)

In general, the result of the elimination of weakly dominated strategies depends on order. We definenice weak dominance. Under nice weak dominance, order does not matter. We identify an important class of games under which nice weak dominance and weak dominance are equivalent, and so the order under weak dominance does not matter. For all games, the result of iterative nice weak dominance is an upper bound on the result from any order of weak dominance. The results strengthen the intuitive relationship between backward induction and weak dominance and shed light on some computational problems relating to weak dominance.Journal of Economic LiteratureClassification Number: C72.
PD-1, but Not PD-L1, Expressed by Islet-Reactive CD4+ T Cells Suppresses Infiltration of the Pancreas During Type 1 Diabetes (2013)

The inhibitory receptor programmed death-1 (PD-1) constrains type 1 diabetes (T1D) in the nonobese diabetic (NOD) mouse. However, how PD-1 influences diabetogenic CD4(+) T cells during natural diabetes is not fully understood. To address this question, we developed a novel model to investigate antigen-specific CD4(+) T cells under physiological conditions in vivo. We transferred a low number of naïve CD4(+) T cells from the BDC2.5 mouse into prediabetic NOD mice to mimic a physiological precursor frequency and allowed the cells to become primed by endogenous autoantigen. Transferred BDC2.5 T cells became activated, differentiated into T-bet(+) IFN-γ-producing cells, and infiltrated the pancreas. In this model, loss of PD-1, but not programmed death ligand-1 (PD-L1), on the antigen-specific CD4(+) T cell resulted in increased cell numbers in the spleen, pancreas-draining lymph node, and pancreas. PD-1 deficiency also increased expression of the chemokine receptor CXCR3. Lastly, histological data showed that a loss of PD-1 caused BDC2.5 cells to penetrate deep into the islet core, resulting in conversion from peri-insulitis to destructive insulitis. These data support a model by which PD-1 regulates islet-reactive CD4(+) T cells in a cell intrinsic manner by suppressing proliferation, inhibiting infiltration of the pancreas, and limiting diabetes.
A π/4-shifted differential 8PSSK modulation for high data rate WBAN system (2009)

This paper proposes a new modulation scheme for high data rate WBAN in-body communication systems. We propose a π/4-shifted differential 8-PSSK scheme that includes its architectures for the transmitter and receiver. Simulation results are presented in terms of performance, modulation options and frequency tolerance.
Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine (1997)

We have previously reported that a 19-base pair element of the 5'-flanking region of the inducible nitric oxide synthase (iNOS) gene containing a sequence homology to a hypoxia-responsive enhancer (iNOS-HRE) mediates picolinic acid (PA)- or hypoxia-induced activation of the iNOS promoter in interferon-gamma (IFN-gamma)-treated murine macrophages. The iron chelator desferrioxamine (DFX) induces the activity of the human erythropoietin enhancer in Hep3B cells. We have investigated the influence of DFX on the activation of the iNOS promoter and iNOS gene expression in ANA-1 macrophages. We have found that DFX induced DNA-binding activity to the hypoxia-inducible factor 1 (HIF-1) consensus sequence of the iNOS promoter and activated the iNOS-HRE in murine macrophages. These activities of DFX were associated with a synergistic induction of iNOS mRNA expression and iNOS transcription in IFN-gamma-treated ANA-1 macrophages. Functional analysis of the 5'-flanking region of the iNOS gene demonstrated that IFN-gamma plus DFX activated the full-length iNOS promoter and that the iNOS-HRE was required for DFX-induced iNOS transcriptional activity. We also investigated the role of iron metabolism in the DFX- or PA-dependent induction of HIF-1 activity and iNOS expression. We demonstrate that addition of iron sulfate completely abolished DFX or PA induction of HIF-1 binding and iNOS-HRE activation and abrogated IFN-gamma plus either DFX- or PA-induced iNOS expression. These data establish that DFX is a co-stimulus for the transcriptional activation of the iNOS gene in IFN-gamma-treated macrophages, and they provide evidence that the iNOS-HRE is required for the DFX-dependent activation of the iNOS promoter. Furthermore, our results indicate that the iNOS-HRE is a regulatory element of the iNOS promoter responsive to iron chelation.
Thyroid Hormone Gene Targets in ROS 17/2.8 Osteoblast-Like Cells Identified by Differential Display Analysis (2002)

Thyroid hormone plays an important role in bone development and metabolism. We used a polymerase chain reaction (PCR)-based mRNA differential display (DD) analysis to obtain a profile of thyroid hormone-responsive genes in osteoblast-like cells (ROS 17/2.8). ROS 17/2.8 cells were treated with 10(-8) M triiodothyronine (T(3)) for 2 and 24 hours. Total RNA was isolated, reverse-transcribed, and amplified using a total of 72 combinations (2 hours) and 240 combinations (24 hours) of 5' and 3' primers. At the 2-hour time point, 1 true-positive novel clone was identified and shown to be the mitochondrial gene, subunit 6 of ATP synthase (ATPase-6). At the 24-hour time point, 3 differentially expressed (DE) mRNAs were confirmed as true-positives including; nonmuscle alkali myosin light chain (NM aMLC), ATPase-6, and one novel clone. T(3)-induction of ATPase-6 mRNA in ROS 17/2.8 cells was seen at 2 and 4 hours, but was maximal at 24 hours (2.1-fold). T(3) induction of ATPase-6 mRNA was increased to fourfold in ROS 17/2.8 cells cultured at a low density. NM aMLC mRNA was modestly upregulated by T(3) in ROS 17/2.8 cells by 1.4-fold, and induction was augmented at low cell density to 1.7-fold. T(3) action on NM aMLC and on the mitochondrial gene ATPase 6, represent novel targets and potential mediators of thyroid hormone action on bone. Cell type, and the extent of cell differentiation, influences T(3) regulation of genes in osteoblast-derived cells.
[The development of spinal endoscope using a flexible optic fiber]. (1989)

The development of spinal endoscope using a thin (0.75 mm in diameter) flexible fiber catheter AS-001, Fukuda-densi Co Ltd., Japan) is described in this study. This fiber catheter contains 3,000 optic fibers as imaging and illuminating fibers within its diameter. The effective length and the visual angle is 1.10 m and 53 degree, respectively. Video processor system was connected to this fiber catheter. With a patient in the lateral decubitus position under local anesthesia, this fiber catheter was introduced into the lumbar subarachnoid space in a similar manner as lumbar spinal drainage. Eight patients with myelopathy were evaluated by this spinal endoscopic study. With other radiological diagnostic modalities such as myelography, selective spinal angiography using intraarterial digital subtraction angiography (DSA), or magnetic resonance imaging (MRI), it was difficult to make definitive diagnosis in these 8 patients. In 4 patients among them, vascular tangle, or tortuous course of the dilated vessels were visualized on the dorsal surface of the spinal cord by the spinal endoscopic study, which strongly suggested the spinal arteriovenous malformation. In 3 of them, operative findings verified these preoperative endoscopic diagnoses to be correct. In the remaining case, surgical intervention was not attempted because of the personal affair of the patient. In every case, several structures around the thoracolumbar cord such as spinal dura mater, arachnoid membrane, or conus medullaris were observed under the pulsation of the cerebrospinal fluid. No complication was associated with this spinal endoscopic study. About 10 minutes were required for the whole procedure.(ABSTRACT TRUNCATED AT 250 WORDS)
Human pancreatitis and the role of cathepsin B (2006)

Any assumption about the role of the newly detected cathepsin B polymorphisms in pancreatitis must, for now, remain speculative
Sweeping Jet Actuators - A New Design Tool for High Lift Generation (2013)

Active Flow Control (AFC) experiments performed at the Caltech Lucas Wind Tunnel on a generic airplane vertical tail model proved the effectiveness of sweeping jets in improving the control authority of a rudder. The results indicated that a momentum coefficient (Cµ) of approximately 2 % increased the side force in excess of 50 % at the maximum conventional rudder deflection angle in the absence of yaw. However, sparsely distributed actuators providing a collective Cµ ≈ 0.1 % were able to increase the side force in excess of 20%. This result is achieved by reducing the spanwise flow along the swept back rudder and its success is attributed to the large sweep back angle of the vertical tail. This current effort was sponsored by the NASA Environmentally Responsible Aviation (ERA) project. I.
Erratum: ‘‘Microstructure and texture evolution of Cr thin films with thickness’’ [J. Appl. Phys. <b>74</b>, 5025 (1993)] (1994)

Some features in Fig. 2 were lost during
Functions of CRK1 Gene of Candida albicans as Studied by Gene Knock-out. (1999)

In the course of screening MAPK related protein kinase genes from Candida albicans DNA library, a CRK1 (CDC2-related protein kinase) gene was identified. Deletion of the CRK1 gene significantly decreased the growth. rate of cells. CRK1 knock out strains precipitated more rapidly in YPD liquid medium. The CRK1 null mutant stimulated hyphae formation in Lee's liquid medium at pH 4.5 and 25 degrees, which is the medium that maintains the wild type Candida albicans strain in yeast form. These phenomena suggest that CRK1 gene may be involved in cell cycle, flocculation and morphogenesis of Candida albicans. Overexpression of the half length CRK1 gene could induce the invasive growth into agar faintly, the cells that was capable of the invasive growth also changed their cell shapes to long, thin pseudohyphal-like cells, but the full-length CRK1 had only weak effect. The Crk1p might promote the invasive growth or cell elongation through a route different from the MAPK signal transduction pathway.
Steryl glucoside concentration declines with Cycas micronesica seed age (2006)

Neurotoxins contained in the seeds of Cycas micronesica K.D. Hill have been implicated in the Guam neurological disease cluster, amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS-PDC). Some of these neurotoxins remain in the washed cycad seed flour that was historically an important part of the Chamorro diet. Of these, variant steryl glucosides have been identified by us as a possible etiological factor in the disease. In vitro and in vivo animal studies have strongly supported a role for these molecules in some forms of neurodegeneration. As part of a series of studies, we have now determined the concentrations of several steryl glucosides and their sterol precursors as affected by the age of C. micronesica seeds. The concentration of these molecules declined with seed age from 2.0 to 30.5 months. Following log-transformation of both axes, the decline was linear. Similarly, concentration of all but one of the molecules declined with age when samples were restricted to gametophyte tissue. Factors suspected of influencing phenotypic plasticity must be addressed when interpreting plant physiology data. Our results confirm for the first time that tissue age must be documented and reported in cycad seed biochemistry studies to remove ambiguities from results. Past studies in this important area of research have failed to account for the potential impact of seed age, rendering previous outcomes and interpretations of cycad neurotoxins in their impact on ALS-PDC ambiguous.
Model Study of Different Antioxidant Properties of α‐ and γ‐Tocopherol in Fats (1990)

Abstract A model study using 2,2,5,7,8‐pentamethyl‐6‐hydroxychroman (α‐COH) and 2,2,7,8‐tetramethyl‐6‐hydroxychroman (γ‐COH) as antioxidants, and linoleic acid and its methyl ester (both in bulk phase) as the lipids was performed. After having demonstrated that the antioxidative activities of the model substances did agree with those of the corresponding tocopherols (α‐T, γ‐T), the stability of α‐COH and γ‐COH was determined, and the products arising from α‐COH, γ‐COH, linoleic acid and its methyl ester were identified. α‐COH did oxidize to different major products (quinone, trimer) depending on the reaction temperature (37°C and 47°C) and the antioxidant concentration, whereas the products obtained by oxidation of γ‐COH (diphenyl ether dimer, biphenyl dimer) did not seem to be affected by differences in the reaction conditions. It was concluded that γ‐T was superior to α‐T as antioxidant because it appears more stable and, also, being oxidized to compounds which are still effective as antioxidants.
A Comparison of Criteria for Maximum Entropy/ Minimum Divergence Feature Selection (1998)

In this paper we study the gain, a naturally-arising statistic from the theory of memd modeling [2], as a figure of merit for selecting features for an memd language model. We compare the gain with two popular alternatives---empirical activation and mutual information---and argue that the gain is the preferred statistic, on the grounds that it directly measures a feature &apos;s contribution to improving upon the base model. Introduction Maximum entropy / minimum divergence (memd) modeling is a powerful technique for building statistical models of linguistic phenomena. It has been applied to problems as diverse as machine translation [2], parsing [10], word morphology [5] and language modeling [6, 11, 3, 9]. The heart of the method is to choose a collection of informative features, each encoding some linguistically significant event, and then to incorporate these features into a family of conditional models. A fundamental issue in applying this technique is the criterion used to select f...
Combined regulation of ornithine and <i>S</i>-adenosylmethionine decarboxylases by spermine and the spermine analogue <i>N</i>1<i>N</i>12-bis(ethyl)spermine (1990)

In the present study, the spermine (SPM) analogue N1N12-bis(ethyl)spermine (BESPM) is compared with SPM in its ability to regulate ornithine decarboxylase (ODC) and S-adenosyl-L-methionine decarboxylase (AdoMetDC) activities in intact L1210 cells and in the mechanism(s) by which this is accomplished. Unlike the comparable spermidine (SPD) analogue N1N8-bis(ethyl)spermidine, which regulates only ODC, BESPM suppresses both ODC and AdoMetDC activities. With 1 microM-SPM or -BESPM, near-maximal suppression of enzyme activity (i.e. less than 70%) was achieved after 2 h for ODC and 12 h for AdoMetDC. After such treatment, ODC activity fully recovered within 2-4 h, and that of AdoMetDC within 12 h, when cells were reseeded into drug-free media. It was deduced that an intracellular accumulation of BESPM or SPM equivalent to only approximately 200-450 pmol/10(6) cells was sufficient to fully invoke ODC regulatory mechanisms. Decreases in both enzyme activities after BESPM or SPM treatment were closely paralleled by concomitant decreases in the amount of enzyme protein. Since cellular ODC or AdoMetDC mRNA was not similarly decreased by either BESPM or SPM treatment, it was concluded that translational and/or post-translational mechanisms were probably responsible for enzyme regulation. In support of the former of these possibilities, it was demonstrated that both BESPM and SPM preferentially inhibited the translation in vitro of ODC and AdoMetDC relative to albumin in a reticulocyte-lysate system. On the basis of the consistent similarities between BESPM and SPM in all parameters studied, it is concluded that the analogue most likely acts by mechanisms identical with those by which SPM acts in suppressing polyamine biosynthesis.
Residue-Dependent Adsorption of Model Oligopeptides on Gold (2013)

The adsorption to gold surfaces in aqueous solutions has been systematically evaluated for a series of model oligopeptides. The series includes GG-X-GG "host-guest" sequences, where the central X residue is one of 19 proteinogenic amino acids, and water-soluble X5 and X10 homo-oligopeptides. Irreversible adsorption on gold of GG-X-GG peptides, which lack significant secondary structure, was quantitatively analyzed by X-ray photoelectron spectroscopy (XPS). The broad range of the quasi-equilibrium surface densities measured by XPS corroborates the hypothesis that surface interactions of GG-X-GG peptides are dominated by their central X residues. The highest surface density was produced by GGCGG, followed by sequences with hydrophobic, charged, and polar central residues. Neither electrostatic nor hydrophobic interactions dominate the adsorption of GG-X-GG peptides: for charged and polar central residues, surface densities correlate with the size of the side chains but not with the sign of the charges, while for hydrophobic residues, the surface densities are uncorrelated with side-chain hydrophobicity. An intriguing result is the disparity in surface adsorption of structural isomers of Leu and Val, which exhibit a correlation between the position of the branched carbon in the side chain and the interaction of the peptide backbone with the surface. The surface density produced by the adsorption of GG-X-GG peptides overall was low; however, adsorption tended to increase as the number of X residues increased (GG-X-GG < X5 < X10), suggesting that cooperative binding is important for surface attachment of proteins that readily adsorb on inorganic surfaces. The Leu and Val isomer investigation and trends revealed by our analysis show how the methodology and results described here provide a fundamental reference for future experimental and computational studies and for rational design of peptides that exhibit predictable adsorption behaviors on a given surface.
Analysis of Nitric Oxide (NO) in Cerebral Vasospasm After Aneursymal Bleeding (2007)

Nitric oxide (NO) is produced by the endothelial NOS (eNOS) in the intima and by the neuronal NOS (nNOS) in the adventitia of cerebral vessels. By activating soluble guanylyl cyclase, NO increases the production of 3'-5'cGMP, which relaxes smooth muscle cells and dilates the arteries in response to shear stress, metabolic demands and changes of pCO(2) (chemoregulation). 3'-5'cGMP is then metabolized by phosphodiesterases (PDEs). Aneurysmal subarachnoid hemorrhage (SAH) interrupts this regulation of cerebral blood flow (CBF). Oxyhemoglobin, gradually released from the subarachnoid clot enveloping the conductive arteries, scavenges NO and destroys nNOS-containing neurons. This deprives the arteries of NO, leading to vasoconstriction which initiates delayed vasospasm. This arterial narrowing increases shear stress and stimulates eNOS, which under normal conditions would lead to increased production of NO and dilation of arteries. However, this does not occur because of transient eNOS dysfunction evoked by increased levels of an endogenous NOS inhibitor, asymmetric dimethylarginine (ADMA). Increased ADMA levels result from decreased elimination due to inhibition of the ADMA-hydrolyzing enzyme (DDAH 2) in arteries in spasm by hemoglobin metabolites, bilirubin-oxidized fragments (BOXes). This eNOS dysfunction sustains vasospasm until ADMA levels decrease and NO release from endothelial cells increases. This NO-based pathophysiological mechanism of vasospasm suggests that exogenous delivery of NO, modification of PDE activity, inhibition of the L-arginine-methylating enzyme (I PRMT 3) or stimulation of DDAH 2 may provide new therapies to prevent and treat vasospasm. This paper summarizes experimental and early clinical data that are consistent with the involvement of NO in delayed cerebral vasospasm after SAH and which suggests new therapeutic possibilities.