gebhart/patrepeval huggingface dataset:
The Importance of Intervention in Developing Self-regulated Learners (2012)

In academic and educational field, self-regulated learning has been viewed and still being considered as essential learning procedures that could influence students learning behavior and their achievement levels. Most research findings have proven that students who are self-regulated learners perform better than students who are not. However, research on self-regulated learning in Malaysia mainly focuses on investigation of self-regulated factors that affect students learning. The purpose of this study is to investigate students ’ motivational level and use of learning strategies in learning History before and after the intervention program. In order to attain comprehensive picture and rich information for teachers and policy makers to design appropriate learning contexts in schools, self-regulatory strategies used in this study has been integrated into Secondary Four History. Sequential quantitative and qualitative data collections were engaged to obtain a deep insight of the findings results. Convergence and divergence data emerged between students ’ responses on the questionnaire and interview for particular constructs within self-regulatory strategies in the intervention. Distinctive data should be considered as the pointer to new theoretical insight.
Lipase secretion from dispersed rabbit gastric glands (1985)

We have measured gastric lipase activity in dispersed glands of rabbit stomach by quantitating the hydrolysis of tri[3H]olein. Lipase activity in isolated gastric glands was 200-400 nmol [3H]oleic acid released per milligram dry weight per minute. The percentage of lipase activity released during incubation for 30 min at 37 degrees C under basal conditions was 1.5-4.5%. Lipase release was stimulated by secretagogues: 10 nM cholecystokinin octapeptide (CCK-8) and 100 microM carbachol led to four- to sixfold and two- to threefold higher enzyme secretion, respectively, while histamine had no effect. Carbonyl cyanide m-chlorophenylhydrazone (30 microM) completely inhibited the CCK-8-induced lipase release, indicating that lipase secretion is dependent on mitochondrial oxidative energy; dibutyryl cGMP (1 mM) inhibited 1 nM CCK-8-stimulated but not 100 microM carbachol-stimulated secretion; atropine (1 microM) had the opposite effect. These studies suggest that secretion of lipase from isolated gastric glands is stimulated by at least two receptor mechanisms. These studies show that a lipase that hydrolyzes long-chain triglyceride is secreted by rabbit stomach mucosa and that the secretion of gastric lipase is stimulated by two different receptor mechanisms.
Security testing as a service with docker containerization (2017)

Nowadays web applications are used widely in day to day life. These web applications need to be secured from security vulnerabilities. In order to test how much a web application is secured enough to stand against security attacks, security testers use various web vulnerability scanners. However, in order to run security scans as expected, these tools have to be properly configured and also require lots of computational resources. So anyone who is interested in doing a security scanning should have a thorough knowledge on configuration and usage of web vulnerability scanners to achieve required strength of security.
New Substrates and Enzyme Assays for the Detection of Mucopolysaccharidosis III (Sanfilippo Syndrome) Types A, B, C, and D by Tandem Mass Spectrometry (2012)

The clinical phenotype of Sanfilippo Syndrome is caused by one of four enzyme deficiencies that are associated with a defect in mucopolysaccharide metabolism. The four subtypes (A, B, C, and D) are each caused by an enzyme deficiency involved in the degradation of heparan sulfate. We have developed a highly efficient synthesis of the substrates and internal standards required for the enzymatic assay of each of the four enzymes. The synthesis of the substrates involves chemical modification of a common intermediate. The substrates and internal standards allow the measurement of the enzymes relevant to heparan N-sulfatase (type A); N-acetyl-α-glucosaminidase (type B); acetyl-CoA:α-glucosamide N-acetyltransferase (type C); and N-acetylglucosamine 6-sulfatase (type D). The internal standards are similar to the substrates and allow for the accurate quantification of the enzyme assays using tandem mass spectrometry. The synthetic substrates incorporate a coumarin moiety and can also be used in fluorometric enzyme assays. We confirm that all four substrates can detect the appropriate Sanfilippo Syndrome in fibroblast lysates, and the measured enzyme activities are distinctly lower by a factor of 10 when compared to fibroblast lysates from unaffected persons.
Potential Applications of Therapeutic Drug Monitoring of Sirolimus Immunosuppression in Clinical Renal Transplantation (1995)

Sirolimus is a potent immunosuppressive agent with a novel mechanism of action. It inhibits the transduction of cytokine signals necessary for the proliferation and maturation of T cells. Because sirolimus blocks a broad spectrum of cytokine signals, it seems logical to use it as an adjunct to CsA-based immunosuppression. The high degree of synergy between these two agents, as suggested by the rigorous median-effect analysis, has been confirmed by a reduced rate of rejection episodes among human renal allograft recipients. However, Phase I studies document wide interindividual variation in the pharmacokinetic parameters of 26 stable renal transplant patients, thereby suggesting that optimal therapy may require monitoring of drug concentrations, which is a task that has been somewhat simplified by the good correlation of trough level to AUC. Development of a monoclonal antibody assay system may simplify the monitoring of drug concentrations further. Additional studies of sirolimus will be required to determine the therapeutic concentrations and ratios of sirolimus to CsA that provide optimal immunosuppression, and to assess the possibility of a steroid-free regimen.
Visual acuity at intermediate distances after implantation of different models of intraocular lenses (2012)

Aim. To study the rehabilitative effect of treatment of cataracts by implanting trifocal refractive-diffractive soft intraocular lens MIOL-Record 3. Methods. 192 patients (216 eyes) who were operated on for cataract participated in the study. The first (main) group included 63 patients (72 eyes) in whom cataract extraction and implantation of the domestic trifocal refractive-diffractive monolithic (soft) intraocular lens MIOL-Record 3 was performed. The second group included 64 patients (70 eyes) in whom cataract extraction and implantation of the domestic bifocal refractive-diffractive lens MIOL-Accord was performed. The third group consisted of 65 patients (74 eyes) in whom cataract extraction and implantation of the domestic monofocal lens MIOL-2 was performed. Preoperative examination was performed the day before surgery, postoperative - after 7 days, 1, 3, 6 and 12 months. Results. The mean value of visual acuity at a distance of 50 cm without correction in the group of patients with MIOL-Record 3 1 month after surgery was 0.42±0.01 and was significantly higher than such in patients with MIOL-Accord and MIOL-2 - 0.14±0.01 and 0.1±0.001, respectively. A questionnaire survey revealed that in the group with MIOL-Record 3 additional correction with glasses is never used at the intermediate distance in 98.62% of the cases, in groups with MIOL-Accord - in 54.28%, and with MIOL-2 - in 25.68% of cases. Patients with MIOL-Record 3 were completely satisfied with the results of surgery in 70.84% of the cases, and in groups with MIOL-Accord and MIOL-2 - in 54.28, and 27.03% of cases, respectively. Conclusion. The conducted studies have established the best rehabilitative effect of the treatment of cataract during implantation of a trifocal refractive-diffractive intraocular lens MIOL-Record 3.
Computer Vision Metrics: Survey, Taxonomy, and Analysis (2014)

Computer Vision Metrics provides an extensive survey and analysis of over 100 current and historical feature description and machine vision methods, with a detailed taxonomy for local, regional and global features. This book provides necessary background to develop intuition about why interest point detectors and feature descriptors actually work, how they are designed, with observations about tuning the methods for achieving robustness and invariance targets for specific applications. The survey is broader than it is deep, with over 540 references provided to dig deeper. The taxonomy includes search methods, spectra components, descriptor representation, shape, distance functions, accuracy, efficiency, robustness and invariance attributes, and more. Rather than providing âhow-toâ source code examples and shortcuts, this book provides a counterpoint discussion to the many fine opencv community source code resources available for hands-on practitioners.
Oral Health 2020 (2020)

We are delighted to welcome all enthusiastic researchers from all around the world to join us for the Webinar on Dental Management and Oral Health on October 14th, 2020.The summit will be forward with the theme Innovative Trends in Dental & Oral Health
Acoustic Wave and Electromechanical Resonators: Concept to Key Applications (2010)

This groundbreaking book provides you with a comprehensive understanding of FBAR (thin-film bulk acoustic wave resonator), MEMS (microelectomechanical system), and NEMS (nanoelectromechanical system) resonators. For the first time anywhere, you find extensive coverage of these devices at both the technology and application levels. This practical reference offers you guidance in design, fabrication, and characterization of FBARs, MEMS and NEBS. It discusses the integration of these devices with standard CMOS (complementary-metal-oxide-semiconductor) technologies, and their application to sensing and RF systems. Moreover, this one-stop resource looks at the main characteristics, differences, and limitations of FBAR, MEMS, and NEMS devices, helping you to choose the right approaches for your projects. Over 280 illustrations and more than 130 equations support key topics throughout the book.
Identification and Characterization of the Hemophore-Dependent Heme Acquisition System of <i>Yersinia pestis</i> (2001)

Yersinia pestis possesses a heme-protein acquisition system (Hmu) that allows it to utilize heme and heme-protein complexes as the sole sources of iron. Analysis of the Y. pestis CO92 genomic sequence revealed a second heme-protein acquisition gene cluster that shares homology with the hemophore-dependent heme acquisition system (Has system) of Serratia marcescens. This locus consisted of the hasR(yp) receptor gene, the hasA(yp) hemophore gene, and genes encoding components of the HasA(yp) dedicated ABC transporter factor (hasDE(yp)), as well as a tonB homologue (hasB(yp)). By using a reconstituted secretion system in Escherichia coli, we showed that HasA(yp) is a secreted heme-binding protein and that expression of HasA(yp) is iron regulated in E. coli. The use of a transcriptional reporter fusion showed that the hasRADEB promoter is Fur regulated and has increased activity at 37 degrees C. Hemoglobin utilization via the Has(yp) system was studied with both E. coli and Y. pestis, for which has and has hmu mutant strains were used. No contribution of the Has system to heme utilization was observed in either E. coli or Y. pestis under the conditions we tested. Previously it was shown that a deletion of the Hmu system had no effect on the virulence of Y. pestis in a mouse model of bubonic plague. An Hmu(-) Has(-) double mutant also retained full virulence in this model of infection. This report constitutes the first attempt to investigate the contribution of the hemophore-dependent heme acquisition system in bacterial pathogenicity.
The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. (1994)

Type A gamma-aminobutyric acid (GABAA) receptors of the mammalian nervous system are a family of ligand-gated ion channels probably formed from the coassembly of different subunits (alpha 1-6, beta 1-3, gamma 1-3, delta) in the arrangement alpha beta gamma or alpha beta delta. The activation of these receptors by GABA can be modulated by a range of compounds acting at distinct allosteric sites. One such compound is the broad-spectrum anticonvulsant loreclezole, which we have recently shown to act via a specific modulatory site on the beta subunit of the GABAA receptor. The action of loreclezole depends on the type of beta subunit present in the receptor complex; receptors containing beta 2 or beta 3 subunits have > 300-fold higher affinity for loreclezole than receptors containing a beta 1 subunit. We have used this property to identify the amino acid residue in the beta subunit that determines the subunit selectivity of loreclezole. Chimeric beta 1/beta 2 human GABAA receptor subunits were constructed and coexpressed in Xenopus oocytes with human alpha 1 and gamma 2s subunits. The chimera beta 1/beta 2Lys237-Gly334 conferred sensitivity to 1 microM loreclezole. Within this region there are four amino acids that are conserved in beta 2 and beta 3 but differ in beta 1. By mutating single amino acids of the beta 1 subunit to the beta 2/beta 3 equivalent, only the beta 1 mutation of Ser-290-->Asn conferred potentiation by loreclezole. Similarly, mutation of the homologous residue in the beta 2 and beta 3 subunits to the beta 1 equivalent (Asn-->Ser) resulted in loss of sensitivity to loreclezole. The affinity for GABA and the potentiation by flunitrazepam were unchanged in receptors containing the mutated beta subunits. Thus, a single amino acid, beta 2 Asn-289 (beta 3 Asn-290), located at the carboxyl-terminal end of the putative channel-lining domain TM2, confers sensitivity to the modulatory effects of loreclezole.
Advances in application potential of adsorptive-type solid state gas sensors: high-temperature semiconducting oxides and ambient temperature GasFET devices (2008)

This paper reviews some scientific considerations about the underlying material properties and the detailed functional principle of two important types of solid state gas sensors. This is used to predict the application potential of these sensor technologies. The classical methodology to use resistance readout of heated semiconducting metal oxides is a straightforward approach to get robust sensors that are simple in design. The usage of materials that are operated at higher temperatures opens up the way for improvements; due to a change in the mechanism of electrical conductivity, better reproducibility and stability of the electrical properties can be attained. The high operation temperatures also lead to changes in the surface reactions with the gases that allow for quicker equilibration times. The next step is taken when devices are used that are based on the readout of the work function of the sensing materials. Suspended gate FETs here serve as the transducer structures. Surface properties are directly used here, which facilitates the preparation of sensing materials. The sensors can be used with a wide range of sensing materials, allowing the development of receptor materials that optimally fit the target gases. Functional improvements include enhanced selectivity and detection of a wider range of gases. These devices may work at room temperature with little energy required for running them and additionally allow direct access to the structure of the analyte molecule without thermal decomposition.
[Usefulness of NCI-N87 cell lines in Helicobacter pylori infected gastric mucosa model]. (2006)

These results suggest that NCI-N87 cell line may be useful in H. pylori infected gastric mucosa model.
Introducing Brief Therapy into a Community Mental Health Service (2010)

The existence of lengthy wait lists, a not uncommon condition found in many public community mental health services, prompted a small team that was performing the intake function for its clinic to launch a pilot project of Brief Therapy. Amidst a traditionally oriented service and in the face of understandable skepticism, this team constructed a coherent plan of action founded upon the solution focused model of brief therapy. Not only did the results more than validate the team's initial expectations, they so impressed their management team with their data, that even in times of marked fiscal restraint, the Brief Therapy Program was expanded.
Heats of fusion for some triglycerides by differential scanning calorimetry (1969)

Abstract Heats of fusion of tristearin, tripalmitin, trimyristin, trilaurin and several standards were determined by the relatively new technique of Differential Scanning Calorimetry. The data obtained on the standards shows good precision and accuracy. The results obtained for the triglycerides are 1–10% lower than values which have been reported elsewhere.
Atomic force microscopy in cell biology (2002)

Preface, Bhanu P. Jena & Heinrich Horber. Local Probe Techniques, J.K. Heinrich Horber. AFM in the Study of Membrane Fusion and Exocytosis, Bhanu P. Jena, Sang-Joon Cho. AFM Imaging of Cells and Membranes, Christian Le Grimellec, Eric Lesniewska, Pierre Milhiet, Marie-Cecile Giocondi. Measuring the Elastic Properties of Living Cells by AFM, Manfred Radmacher. Cell Adhesion Measured by Force Spectroscopy on Living Cells, Martin Benoit. Molecular Recognition Studies Using AFM, Peter Hinterdorfer. The Biophysics of Sensory Cells of the Inner Ear examined by AFM and Patch Clamp, Matthias G. Langer, Assen Koitschev. Biotechnological Applications of Atomic Force Microscopy, Mike Horton, Guillaume Charras, Petri Lehenkari. Cellular Membranes Studied by Photonic Force Microscopy, Arnd Pralle, Ernst-Ludwig Florin. Methods for Biological Probe Microscopy in Aqueous Fluids, Helen G. Hansma, Johannes H. Kindt, John C. Sitko, Emin Oroudjev, Mario B. Viani, Nathan Becker, Lia I. Pietrasanta. Supported Lipid Bilayers as Effective Substrates for Atomic Force Microscopy, Zhifeng Shao, Daniel M. Czajkowsky. Cryo Atomic Force Microscopy, Zhifeng Shao, Sitong Sheng. Conformations, Flexibility and Interactions Observed on Individual Membrane Proteins by Atomic Force Microscopy, Daniel J. Muller, Andreas Engel. Single Molecule Force Measurements, Vincent T. Moy, Aileen Chen. Forced Unfolding of Single Proteins, Pierre-Francois Lenne, S.M. Altmann. Developments in Dynamic Force Microscopy and Spectroscopy, Mervyn Miles, A.D.L. Humphris. SFM Studies on the Structure and Dynamics of Single DNA Molecules, Bruno Samori, Giampaolo Zuccheri.
Time Course of Thymoxamine Reversal of Phenylephrine-Induced Mydriasis (1990)

We conducted a randomized, double-masked, paired comparison of 0.1% thymoxamine vs placebo for the reversal of phenylephrine-induced mydriasis. Mydriasis was induced with 2.5% phenylephrine in each eye of 74 subjects (148 eyes). Each subject then received 0.1% thymoxamine in one eye and placebo in the other eye. Pupillary measurements were obtained at regular intervals during the ensuing 8 hours. At all intervals, a greater percentage of thymoxamine-treated eyes returned to baseline pupillary diameters compared with placebo-treated eyes (P less than or equal to .01). For subjects in whom both pupils returned to baseline, thymoxamine-treated eyes returned to baseline in a mean of 2.2 hours, vs 5.2 hours for placebo (P less than .0001). Among thymoxamine-treated eyes, those with light irides responded more rapidly than those with dark irides, returning to baseline in 1.6 vs 2.8 hours, respectively (P = .0046). After constriction to baseline pupillary diameter had been achieved, no patients experienced a rebound dilation.
A heterologous reductase affects the redox balance of recombinant Saccharomyces cerevisiae (1996)

Recombinant Saccharomyces cerevisiae harbouring the xylose reductase (XR) gene XYL1 from Pichia stipitis was grown in anoxic chemostat culture at two different dilution rates. At each dilution rate a transient experiment, encompassing a shift in the sugar content of the medium from glucose to glucose plus xylose was performed. The steady states at the beginning and the end of the transients were compared in terms of specific product fluxes from glucose metabolism. At both dilution rates, the specific glycerol flux decreased and the specific acetate and CO2 fluxes increased. The specific ethanol flux was not affected. At the lower dilution rate, the production of biomass decreased during the transient, but at the higher dilution rate it increased. The changes in product pattern can be explained as being due to the redox perturbation caused by the consumption of reduced cofactors in the XR-catalysed reaction. Regeneration of NAD partly through xylose reduction instead of glycerol production decreased the formation of glycerol. Additionally, xylose reduction activated those pathways which produce reduced cofactors, such as acetate formation and the pentose phosphate pathway, indicated by increased acetate and CO2 production. The dual cofactor specificity of XR, with a preference for NADPH over NADH, was evident from the effects of xylose reduction on product fluxes. Comparison of the xylose reduction rates at low and high glucose flux indicated that the supply of reduced cofactors partly controlled the reaction rate. At the higher dilution rate, control by some other factor such as xylose transport or XR activity increased. Calculation of carbon balances at the steady states showed that all substrate carbon was recovered in biomass or products. Based on the specific product fluxes, calculations of quantitative cofactor balances at the steady states was attempted. However, sensitivity calculations showed that analysis errors in the range of 5% caused substantial errors in the cofactor balance, without affecting the carbon balance.
Political regimes, trade, and labor policies in developing countries (1995)

What, if any, is the link between labor market policies that benefit insiders - for example, regulations guaranteeing high minimum wages and strict job security - and political regimes. Is it true that in a democracy outsiders vote and impose limits on what insiders can achieve, whereas in a dictatorship the government need worry only about insiders who have real power? Or are democratic governments more likely to succumb to trade union pressure and use labor policies to give them special privileges? To test these competing hypotheses, the authors designed a two-sector political economy model that demonstrates that labor market distortions depend directly on the trade regime: the more open the trade regime, the fewer distortions in the labor market. They use cross-country regressions to test the relationship between political and civil liberties and trade and labor policies. Using data for 90 developing countries, they apply existing indices of openness and political freedom and two different constructed measures of labor market distortion. Their conclusions, based on the regression results: authoritarian systems that repress labor are more likely than democratic systems to adopt inefficient labor policies inimical to development.
200-MHz electrodeless discharge excitation of an XeF laser (1982)

Two hundred megahertz electrodeless rf discharge excitation of an XeF laser is reported. Laser output of total duration exceeding 300 ns is observed. Onset of discharge inhomogeneity is found to limit duration of the laser pulse and to influence recovery of the active medium.