gebhart/patrepeval huggingface dataset:
Efficient range extrapolation of head-related impulse responses by wave field synthesis techniques (2011)

Head-related impulse responses (HRIRs), which are measured from an acoustic source to the left and right ear, characterize the acoustic properties of the outer ear. Due to the involved measurement effort, HRIRs are typically available only for source positions on a circle or surface of a sphere. Range extrapolation techniques aim at calculating HRIRs with a different source distance. A number of techniques have been proposed in the past which are based on expansions of HRIRs in terms of surface spherical harmonics. This paper presents an alternative approach which bases on the interpretation of a BRIR dataset as virtual loudspeaker array which is driven by Wave Field Synthesis in order to achieve range extrapolation.
Surface-plasmon dispersion relations in chains of metallic nanoparticles: An exact quasistatic calculation (2004)

We calculate the surface-plasmon dispersion relations for a periodic chain of spherical metallic nanoparticles in an isotropic host, including all multipole modes, in a generalized tight-binding approach. For sufficiently small particles $(kd\ensuremath{\ll}1,$ where k is the wave vector and d is the interparticle separation), the calculation is exact. The lowest bands differ only slightly from previous point-dipole calculations provided the particle radius $a\ensuremath{\lesssim}d/3,$ but differ substantially at smaller separation. We also calculate the dispersion relations for many higher bands, and estimate the group velocity ${v}_{g}$ and the exponential decay length ${\ensuremath{\xi}}_{D}$ for energy propagation for the lowest two bands due to single-grain damping. For $a/d=0.33,$ the result for ${\ensuremath{\xi}}_{D}$ is in qualitative agreement with experiments on gold nanoparticle chains, while for smaller separation, such as $a/d=0.45,$ ${v}_{g}$ and ${\ensuremath{\xi}}_{D}$ are expected to be strongly k dependent because of the multipole corrections. When the particles touch, we predict percolation effects in the spectrum, and find surprising symmetry in the plasmon band structure. Finally, we reformulate the band-structure equations for a Drude metal in the time domain, and suggest how to include localized driving electric fields in the equations of motion.
Revealing the copy and paste habits of end users (2009)

Transferring data across applications is a common end user task, and copying and pasting via the clipboard lets users do so relatively easily. Using the clipboard, however, can also introduce inefficiencies and errors in user tasks. To help researchers and tool developers understand and address these problems, we studied how end users interact with the clipboard through cut, copy, and paste actions. This study was performed by logging clipboard interactions while end users performed everyday tasks. From the clip-board usage data, we have identified several usage patterns that describe how data is transferred within the desktop environment. Such patterns help us understand end user behavior and indicate areas in which clipboard support tools can be improved.
Active flow identifiers for scalable, QoS scheduling in 10-Gbps network processors (2003)

Most of the scheduling schemes proposed in the literature require complex calculations per flow and thus, their implementations are expensive, especially in terms of silicon area. Additionally, when these algorithms work at gigabit rates, they cannot support large numbers of network flows each with diverse rate requirements. Although nowadays it is technologically viable to implement such mechanisms that can provide QoS in hardware, this can be accomplished only if lower rates (couple of hundreds Mbits/sec at most) or small number of flows (few hundreds) are serviced by the scheduling mechanism. This paper introduces a novel scheduling scheme which can handle thousands of traffic flows, each with its own QoS parameters, at an aggregate rate of 10 Gbps. The hardware implementation of this algorithm requires only 17500 standard CMOS gates. This novel scheme is also very flexible and thus it can very easily be integrated in a large number of different high-performance networking Systems-on-Chip (SoCs).
The metal carbonyls. I. History; II. Preparation (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe metal carbonyls. I. History; II. PreparationWilliam E. Trout Cite this: J. Chem. Educ. 1937, 14, 10, 453Publication Date (Print):October 1, 1937Publication History Received3 August 2009Published online1 October 1937Published inissue 1 October 1937https://doi.org/10.1021/ed014p453RIGHTS & PERMISSIONSArticle Views466Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (5 MB) Get e-Alerts Get e-Alerts
Modulation of Cell-Mediated Immune Response in B16F-10 Melanoma-Induced Metastatic Tumor-Bearing C57BL/6 Mice by Sulforaphane (2007)

Effect of sulforaphane on cell-mediated immune response (CMI) was studied in B16F-10 melanoma-induced metastasis-bearing C57BL/6 mice. Administration of sulforaphane significantly enhanced natural killer (NK) cell activity in metastatic tumor-bearing animals (43.17% cell lysis, on day 5) and the activity was observed earlier than in tumor-bearing control animals (maximum of 9.76% cell lysis, on day 9). Antibody-dependent cellular cytotoxicity also was enhanced significantly in metastatic tumor-bearing animals (41.20% cell lysis on day 9) after sulforaphane administration compared with untreated control tumor-bearing animals (maximum of 12.62% cell lysis on day 15). An early antibody-dependent complement-mediated cytotoxicity also was observed in sulforaphane-treated tumor-bearing animals (26% cell lysis, on day 15). Administration of sulforaphane significantly enhanced the production of IL-2 and IFN-gamma in metastatic tumor-bearing animals. In addition, sulforaphane significantly downregulated the serum levels of proinflammatory cytokines such as IL-1beta, IL-6, TNF-alpha, and GM-CSF during metastasis. These data clearly suggest that sulforaphane effectively inhibited the spread of metastatic tumor cells through the stimulation of CMI, upregulation of IL-2 and IFN-gamma, and downregulation of proinflammatory cytokines IL-1beta, IL-6, TNF-alpha, and GM-CSF.
Resistance of Human Periodontal Ligament Fibroblasts to the Cytolethal Distending Toxin of <i>Actinobacillus actinomycetemcomitans</i> (2005)

These results demonstrate that HPLF are resistant to the cytotoxic effects of the A. actinomycetemcomitans CDT. The mechanism of resistance is not known but may be related to the inability of the toxin to cause DNA damage. The difference in sensitivities of HPLF and oral epithelial cells to the CDT has important implications for the role of this putative microbial virulence factor in periodontal pathogenesis.
Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice (2004)

APEX2/APE2 is a secondary mammalian apurinic/apyrimidinic endonuclease that associates with proliferating cell nuclear antigen (PCNA), and the progression of S phase of the cell cycle is accompanied by its expression. To determine the biologic significance of APEX2, we established APEX2-null mice. These mice were about 80% the size of their wild-type littermates and exhibited a moderate dyshematopoiesis and a relatively severe defect in lymphopoiesis. A significant accumulation of both thymocytes and mitogen-stimulated splenocytes in G(2)/M phase was seen in APEX2-null mice compared with the wild type, indicating that APEX2 is required for proper cell cycle progression of proliferating lymphocytes. Although APEX2-null mice exhibited an attenuated immune response against ovalbumin in comparison with wild-type mice, they produced both antiovalbumin immunoglobulin M (IgM) and IgG, indicating that class switch recombination can occur even in the absence of APEX2.
Metabolic Impact of 4-Hydroxynonenal on Macrophage-Like RAW 264.7 Function and Activation (2012)

Metabolic profiling of macrophage metabolic response upon exposure to 4-hydroxynonenal (HNE) demonstrates that HNE does not simply inactivate superoxide-generating enzymes but also could be responsible for the impairment of downfield signaling pathways. Multianalyte microphysiometry (MAMP) was employed to simultaneously measure perturbations in extracellular acidification, lactate production, and oxygen consumption for the examination of aerobic and anaerobic pathways. Combining the activation of oxidative burst with phorbol myristate acetate (PMA) and the immunosuppression with HNE, the complex nature of HNE toxicity was determined to be concentration- and time-dependent. Further analysis was utilized to assess the temporal effect of HNE on reactive oxygen species (ROS) production and on protein kinase C (PKC). Increased levels of HNE with decreasing PKC activity suggest that PKC is a target for HNE adductation prior to oxidative burst. Additionally, localization of PKC to the cell membrane was prevented with the introduction of HNE, demonstrating a consequence of HNE adductation on NADPH activation. The impairment of ROS by HNE suggests that HNE has a greater role in foam cell formation and tissue damage than is already known. Although work has been performed to understand the effect of HNE's regulation of specific signaling pathways, details regarding its involvement in cellular metabolism as a whole are generally unknown. This study examines the impact of HNE on macrophage oxidative burst and identifies PKC as a key protein for HNE suppression and eventual metabolic response.
Avoiding the data leakage and providing privacy to data in networking (2016)

Leakage of data has significantly taken place in the recent year. Basically Statistics from security companies, analysis institutions and government companies faces the problems of data leakage. From the distinct data leak cases, the main reason of the data leak is from data leak by the human mistake. A large number of researcher work focus on this issues for detecting inadvertent sensitive, private, secret data leak occurred by the mistakes of human being. In the existing system solve the problem of data leak, existing method implement the method for detecting the data leak. But this method does not provide the security to the data or the system. The existing method is not secured. Therefore in the proposed method introduced the technique which provides security to the data leak detection system. Also we introduced the concept of digital envelope, in which encrypt the data and send to the DLD system. System used ECC algorithm for security purpose. Also introduced the bloom filter system for storing the hash values of the data. Finally measure the experimental result plot the graph and compare the result among existing and proposed system.
Qsar Study Of 1,10-Phenanthroline Derivatives As The Antimalarial Compounds Using Electronic Descriptors Based On Semiempirical Am1 Calculation = Kajian QSAR Senyawa Antimalaria Turunan 1,10-Fenantrolin Menggunakan... (2002)

ABSTRACT\nQuantitative Structure-Activity Relationship (QSAR) analysis of 1,10-phenantroline analogs as antimalarial drug has been conducted using atomic net charges (q) as predictors of their activity. Data of predictors are obtained from computational chemistry method using semi-empirical molecular orbital AM1 calculation. Antimalarial activities are taken as the activity of the drugs against plasmodium falciparum (FcM29-Cameroun) strain and are presented as the value of In(1/1050) where /C50 is an effective concentration inhibiting 50 % of the parasite growth. The results show that there is correlation between antiplasmodial activity and electronic structure as represented by a linear function of activity versus atomic net charges of N1, C7, C10, C14 atoms on the 1,10-phenanthroline skeleton and is expressed by :\nlog IC50 = -3,4398 â 14,9050 qAli â 8,5589 qCio â 14,7565 qC7 + 5,0457 qCii\nThe equation is significant at 95% level with statistical parameters : n = 13
Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs (2014)

Vascularization remains a critical challenge in tissue engineering. The development of vascular networks within densely populated and metabolically functional tissues facilitate transport of nutrients and removal of waste products, thus preserving cellular viability over a long period of time. Despite tremendous progress in fabricating complex tissue constructs in the past few years, approaches for controlled vascularization within hydrogel based engineered tissue constructs have remained limited. Here, we report a three dimensional (3D) micromolding technique utilizing bioprinted agarose template fibers to fabricate microchannel networks with various architectural features within photocrosslinkable hydrogel constructs. Using the proposed approach, we were able to successfully embed functional and perfusable microchannels inside methacrylated gelatin (GelMA), star poly(ethylene glycol-co-lactide) acrylate (SPELA), poly(ethylene glycol) dimethacrylate (PEGDMA) and poly(ethylene glycol) diacrylate (PEGDA) hydrogels at different concentrations. In particular, GelMA hydrogels were used as a model to demonstrate the functionality of the fabricated vascular networks in improving mass transport, cellular viability and differentiation within the cell-laden tissue constructs. In addition, successful formation of endothelial monolayers within the fabricated channels was confirmed. Overall, our proposed strategy represents an effective technique for vascularization of hydrogel constructs with useful applications in tissue engineering and organs on a chip.
Phosphatidylinositol metabolism and membrane fusion (2009)

Membrane fusion underlies many cellular events, including secretion, exocytosis, endocytosis, organelle reconstitution, transport from endoplasmic reticulum to Golgi and nuclear envelope formation. A large number of investigations into membrane fusion indicate various roles for individual members of the phosphoinositide class of membrane lipids. We first review the phosphoinositides as membrane recognition sites and their regulatory functions in membrane fusion. We then consider how modulation of phosphoinositides and their products may affect the structure and dynamics of natural membranes facilitating fusion. These diverse roles underscore the importance of these phospholipids in the fusion of biological membranes.
Improved prognostic classification of patients receiving salvage systemic therapy for advanced urothelial carcinoma. (2015)

311 Background: Previously identified prognostic factors in patients (pts) receiving salvage systemic therapy for advanced urothelial carcinoma (UC) include performance status (PS), liver metastasis (LM), hemoglobin (Hb) and time from prior chemotherapy (TFPC). Given the prognostic impact of peripheral blood neutrophils (N), lymphocytes (L), thrombocytes (T) and albumin (Alb) in other malignancies, we investigated their impact in the salvage setting of advanced UC. Methods: Phase II trials of salvage systemic therapy were utilized. Data on N, L, T and Alb were required in addition to TFPC, Hb, PS and LM status. N, L, T and Alb were categorized as normal, <lower limit of normal (LLN) and >upper limit of normal (ULN). Cox proportional hazards regression was used to evaluate their association with overall survival (OS). An optimal regression model was constructed using forward stepwise selection and risk groups defined using number of identified adverse risk factors. Trial was a stratification factor. Results: Data was obtained from 10 trials accruing 708 pts. Of these, 682 pts had available TFPC, Hb, PS and LM status, while 631, 554, 649 and 491 had N, L, T and Alb available. Median OS was 6.8 (95% CI: 6.0-7.0) months. Neutrophilia (N>ULN), thrombocytosis (T>ULN) and hypoalbuminemia (Alb <LLN) were significant poor prognostic factors for OS on univariate analyses. After adjustment for TFPC <3 months, Hb <10 g/dl, PS >0 and LM status, only thrombocytosis and hypoalbuminemia remained significant (Table). Risk groups were constructed. Median OS was 8.8, 6.3, 5.0 and 3.8 months for n=290, 220, 123 and 49 patients with 0-1, 2, 3 and ≥4 factors. This 6-factor prognostic model was internally validated with an improvement in the c-index from 0.564 to 0.590. Conclusions: The addition of hypoalbuminemia and thrombocytosis to TFPC, Hb, PS and LM status enhanced the prognostic risk groupings in pts receiving salvage systemic therapy for advanced UC. [Table: see text]
Tumor-Induced Hyperlipidemia Contributes to Tumor Growth (2016)

The known link between obesity and cancer suggests an important interaction between the host lipid metabolism and tumorigenesis. Here, we used a syngeneic tumor graft model to demonstrate that tumor development influences the host lipid metabolism. BCR-Abl-transformed precursor B cell tumors induced hyperlipidemia by stimulating very low-density lipoprotein (VLDL) production and blunting VLDL and low-density lipoprotein (LDL) turnover. To assess whether tumor progression was dependent on tumor-induced hyperlipidemia, we utilized the VLDL production-deficient mouse model, carboxylesterase3/triacylglycerol hydrolase (Ces3/TGH) knockout mice. In Ces3/Tgh(-/-) tumor-bearing mice, plasma triglyceride and cholesterol levels were attenuated. Importantly tumor weight was reduced in Ces3/Tgh(-/-) mice. Mechanistically, reduced tumor growth in Ces3/Tgh(-/-) mice was attributed to reversal of tumor-induced PCSK9-mediated degradation of hepatic LDLR and decrease of LDL turnover. Our data demonstrate that tumor-induced hyperlipidemia encompasses a feed-forward loop that reprograms hepatic lipoprotein homeostasis in part by providing LDL cholesterol to support tumor growth.
Detection of endotoxin in antibiotic solutions with Limulus amoebocyte lysate (1983)

Twenty-eight antibiotics were tested with the Limulus amoebocyte lysate assay to determine their non-inhibitory concentrations (NICs). The Limulus amoebocyte lysate assay was found to be a valid test for most of the antibiotics tested; the NICs were found to be greater than the minimum valid test concentrations. Borderline results were obtained with cefamandole nafate and neomycin sulfate. Polymyxin B and colistimethate contained too much endotoxin to permit determination of NICs. The NIC of tetracycline hydrochloride was dependent on the initial concentration of antibiotic. This dependence was most likely caused by the amount of base required to adjust the pH before testing.
Cyclodextrins: application in different routes of drug administration. (2005)

The objective of this review article is to explain the use of cyclodextrin in the different routes of drug administration. The article gives the chemistry of cyclodextrins and addresses the issue of the mechanism of drug release from cyclodextrin complexes. Dilution, competitive displacement, protein binding, change in ionic strength and temperature and drug uptake by tissues are the different release mechanisms of the drug from the drug-cyclodextrin complex discussed here. Use and its limitations in the different drug delivery systems like nasal, ophthalmic, transdermal and rectal drug delivery are explained. The application of the cyclodextrins in the oral drug delivery is detailed in this review. Many studies have shown that cyclodextrins are useful additives in the different routes of drug administration because of increased aqueous solubility, stability, bioavailability and reduced drug irritation.
Computerized identification of early ischemic changes in acute stroke in noncontrast CT using deep learning (2019)

Treatment for patients with acute ischemic stroke is most commonly determined based on findings on noncontrast computerized tomography (CT). Identifying hypoattenuation of the early ischemic changes on CT images is crucial for diagnosis. However, it is difficult to identify hypoattenuation with certainty. We present an atlas-based computerized method using a convolutional neural network (CNN) to identify hypoattenuation in the lentiform nucleus and the insula, two locations where hypoattenuation appears most frequently. The algorithm for this method consisted of anatomic standardization, setting of regions, creation of input images for classification, training on the CNN and classification of hypoattenuation. The regions of the lentiform nucleus and insula were set according to the Alberta Stroke Programme Early CT score (ASPECTS) method, a visual quantitative CT scoring system. AlexNet was used in the classification of the CNN architecture. We applied this method to the lentiform nucleus and insula using a database of 20 patients with right-sided hypoattenuation, 20 patients with left-sided hypoattenuation, and 20 normal subjects. Our method was evaluated using a leave-one-case-out cross-validation test. This new method had an average accuracy of 88.3%, an average sensitivity of 87.5%, and an average specificity of 90% for identifying hypoattenuation in the two regions. These results indicate that this new method has the potential to accurately identify hypoattenuation in the lentiform nucleus and the insula in patients with acute ischemic stroke.
An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria (2010)

Lamin A is formed from prelamin A by four post-translational processing steps-farnesylation, release of the last three amino acids of the protein, methylation of the farnesylcysteine and the endoproteolytic release of the C-terminal 15 amino acids (including the farnesylcysteine methyl ester). When the final processing step does not occur, a farnesylated and methylated prelamin A accumulates in cells, causing a severe progeroid disease, restrictive dermopathy (RD). Whether RD is caused by the retention of farnesyl lipid on prelamin A, or by the retention of the last 15 amino acids of the protein, is unknown. To address this issue, we created knock-in mice harboring a mutant Lmna allele (LmnanPLAO) that yields exclusively non-farnesylated prelamin A (and no lamin C). These mice had no evidence of progeria but succumbed to cardiomyopathy. We suspected that the non-farnesylated prelamin A in the tissues of these mice would be strikingly mislocalized to the nucleoplasm, but this was not the case; most was at the nuclear rim (indistinguishable from the lamin A in wild-type mice). The cardiomyopathy could not be ascribed to an absence of lamin C because mice expressing an otherwise identical knock-in allele yielding only wild-type prelamin A appeared normal. We conclude that lamin C synthesis is dispensable in mice and that the failure to convert prelamin A to mature lamin A causes cardiomyopathy (at least in the absence of lamin C). The latter finding is potentially relevant to the long-term use of protein farnesyltransferase inhibitors, which lead to an accumulation of non-farnesylated prelamin A.