gebhart/patrepeval huggingface dataset:
Effects of Lactobacillus plantarum and Lactobacillus paracasei on the Peripheral Immune Response in Children with Celiac Disease Autoimmunity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial (2019)

Two <i>Lactobacillus</i> strains have proven anti-inflammatory properties by reducing pro-inflammatory responses to antigens. This randomized double-blind placebo-controlled trial tested the hypothesis that <i>L. plantarum</i> HEAL9 and <i>L. paracasei</i> 8700:2 suppress ongoing celiac disease autoimmunity in genetically at risk children on a gluten-containing diet in a longitudinally screening study for celiac disease. Seventy-eight children with celiac disease autoimmunity participated of whom 40 received 10<sup>10</sup> CFU/day of <i>L. plantarum</i> HEAL9 and <i>L. paracasei</i> 8700:2 (probiotic group) and 38 children maltodextrin (placebo group) for six months. Blood samples were drawn at zero, three and six months and phenotyping of peripheral blood lymphocytes and IgA and IgG autoantibodies against tissue transglutaminase (tTG) were measured. In the placebo group, naïve CD45RA+ Th cells decreased (<i>p</i> = 0.002) whereas effector and memory CD45RO+ Th cells increased (<i>p</i> = 0.003). In contrast, populations of cells expressing CD4+CD25<sup>high</sup>CD45RO+CCR4+ increased in the placebo group (<i>p</i> = 0.001). Changes between the groups were observed for NK cells (<i>p</i> = 0.038) and NKT cells (<i>p</i> = 0.008). Median levels of IgA-tTG decreased more significantly over time in the probiotic (<i>p</i> = 0.013) than in the placebo (<i>p</i> = 0.043) group whereas the opposite was true for IgG-tTG (<i>p</i> = 0.062 respective <i>p</i> = 0.008). In conclusion, daily oral administration of <i>L. plantarum</i> HEAL9 and <i>L. paracasei</i> 8700:2 modulate the peripheral immune response in children with celiac disease autoimmunity.
Configuration study of large wind parks (2003)

In this thesis, layouts of various large-scale wind parks, using both AC as well as DC, are investigated. Loss modelling of the wind park components as well as calculations of the energy capture of the turbines using various electrical systems are performed, and the energy production cost of the various park configurations is determined. The most interesting candidate for a DC transmission based wind park was investigated more in detail, the series DC wind park. Finally, the power quality impact in the PCC (point of common coupling) was studied.It was found that from an energy capture point of view, the difference in energy production between various wind turbine systems is very small.Of all the investigated wind park configurations, the wind park with the series connected DC wind turbines seems to have the best potential to give the lowest energy production cost, if the transmission distance is longer then 10-20km. Regarding the series DC wind park it was found that it is the most difficult one to control. However, a control algorithm for the series park and its turbines was derived and successfully tested. Still, several more details regarding the control of the series wind park has to be dealt with.
Viewing‐angle improvement based on Poincaré sphere representation (1998)

Abstract We extended the representation of light propagation through birefringent media on the Poincaré sphere to the case of oblique incidence. The developed representation was used to design a wide viewing‐angle compensation foil for a bi‐level TN‐LCD.
Millimeter wave measurements of explosives and simulants (2010)

Devices using electromagnetic (EM) waves in the GHz range are evolving rapidly. The advancement of this technology for security applications, such as explosives detection and personnel screening, requires an understanding of the optical properties of various materials. Using terahertz time-domain spectroscopy and free space millimeter-wave measurements, the dielectric constant of explosives have been measured. Methods used to standardize the experimental measurement and characterize the EM/material interaction are described. These results have enabled the development of mixtures of benign substances as simulants for testing. A comparison of the anticipated signal returns are presented for the range 100 - 500 GHz for a limited set of explosives and simulants.
γ‐Butyrolactone aus 4‐Hydroxycarbonsäure‐dimethylamiden (1975)

Abstract Durch Behandlung mit saurem Ionenaustauscher in Aceton werden zwölf 4‐Hydroxycarbonsäure‐dimethylamide (3‐Hydroxy‐ N , N ‐dimethyl‐1‐carboxamide) in guten Ausbeuten in die entsprechenden γ‐Butyrolactone umgewandelt.
Integration of neural heuristics into knowledge-based inference (1989)

Summary form only given, as follows. Analogies observed between relief networks and neural networks lead to the plausibility of introducing heuristics developed under the neural network approach into knowledge-based systems. An approach has been developed that maps a rule-based system into the neural architecture in both the structural and the behavioral aspects. Under this approach, the knowledge base and the inference engine are mapped into an entity called conceptualization, where a node represents a concept and a link represents a relation between two concepts. Inference in the conceptualization involves the propagation and combination of activations as well as maximizing information transmission through layers. Learning is based upon a mechanism called backpropagation, which allows proper modification of the connection strengths in order to be adapted to the environment. Finally, the validity of this approach has been demonstrated by experiments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Stable Transmission of 12 OAM States in Air-Core Fiber (2013)

We demonstrate modally pure propagation over a record number (12) of modes in an optical fiber. An air-core fiber enables this by supporting OAM states. We achieve mode purities >10dB over 2m for all states and >20dB after 1km for a 2 state subset.
Aberrant Overexpression of the Rgl2 Ral Small GTPase-specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth through Ral-dependent and Ral-independent Mechanisms (2010)

Our recent studies established essential and distinct roles for RalA and RalB small GTPase activation in K-Ras mutant pancreatic ductal adenocarcinoma (PDAC) cell line tumorigencity, invasion, and metastasis. However, the mechanism of Ral GTPase activation in PDAC has not been determined. There are four highly related mammalian RalGEFs (RalGDS, Rgl1, Rgl2, and Rgl3) that can serve as Ras effectors. Whether or not they share distinct or overlapping functions in K-Ras-mediated growth transformation has not been explored. We found that plasma membrane targeting to mimic persistent Ras activation enhanced the growth-transforming activities of RalGEFs. Unexpectedly, transforming activity did not correlate directly with total cell steady-state levels of Ral activation. Next, we observed elevated Rgl2 expression in PDAC tumor tissue and cell lines. Expression of dominant negative Ral, which blocks RalGEF function, as well as interfering RNA suppression of Rgl2, reduced PDAC cell line steady-state Ral activity, growth in soft agar, and Matrigel invasion. Surprisingly, the effect of Rgl2 on anchorage-independent growth could not be rescued by constitutively activated RalA, suggesting a novel Ral-independent function for Rgl2 in transformation. Finally, we determined that Rgl2 and RalB both localized to the leading edge, and this localization of RalB was dependent on endogenous Rgl2 expression. In summary, our observations support nonredundant roles for RalGEFs in Ras-mediated oncogenesis and a key role for Rgl2 in Ral activation and Ral-independent PDAC growth.
Pulsed operation of a high average power Yb:YAG thin-disk multipass amplifier (2012)

An Yb:YAG thin-disk multipass laser amplifier system was developed operating in a 10 Hz burst operation mode with 800 µs burst duration and 100 kHz intra-burst repetition rate. Methods for the suppression of parasitic amplified spontaneous emission are presented. The average output pulse energy is up to 44.5 mJ and 820 fs compressed pulse duration. The average power of 4.45 kW during the burst is the highest reported for this type of amplifier.
Quantum interference depression in thin metal films with ridged surface (2007)

We discuss what happens when low dimensional regular indents are fabricated on the surface of a thin metal film. Using corresponding theoretical methods, we study the free electron inside a potential-energy box with ridged wall and compare the results to the case with plane walls. It was shown that, ridged geometry of the wall leads to Quantum Interference Depression (QID), or reduction of the density of quantum states for the electron. Results obtained for the potential-energy box were extrapolated to the low-dimensional metals (thin metal films). QID leads to increase of the Fermi level and corresponding reduction of the work function. Experimental possibility of fabricating such indents on the surface of a thin metal film was studied.
Enzymatically produced flavors for fatty systems (1972)

Abstract Technology has been developed for the production of flavor systems via controlled enzyme modification of fats. Lipases and esterases from various sources are used. Fats modified include milk fat and meat fats. A wide range of flavor profiles can be produced via control of enzyme, fat and processing prior to and subsequent to enzyme modification. Applications for the flavor systems include margarine, imitation dairy products, confections and prepared foods.
New systolic arrays for computation of the 1-D discrete wavelet transform (2002)

This paper proposes a new systolic array architectures for computation of the 1-D discrete wavelet transform (DWT). The proposed systolic array consists of L processing element (PE) arrays, where L denotes the number of levels. The proposed PE array computes only the product terms that are required for further computation in higher levels, and the outputs of lowpass and highpass filters are computed in alternate clock cycles. Therefore, the proposed architectures can compute the one-level DWT using a single architecture. Note that the proposed architectures do not require extra processing units whereas the conventional architectures need ones. The required time and hardware cost for computation of the DWT using the proposed systolic arrays are comparable to that of the conventional architectures. The proposed architectures can also be applied to subband decomposition by simply changing the filter coefficients.
Resonance-Based Secure Pairing for Wearables (2018)

Securely pairing wearables with ano-ther device is the key to many promising applications. This paper presents Touch-And-Guard (TAG), a system that uses hand touch as an intuitive manner to establish a secure connection between a wristband wearable and the touched device. It generates secret bits from hand resonant properties, which are obtained using accelerometers and vibration motors. The extracted secret bits are used by both sides to authenticate each other and then communicate confidentially. The ubiquity of accelerometers and motors presents an immediate market for our system. We demonstrate the feasibility of our system using an experimental prototype and conduct experiments involving 12 participants with 1,440 trials. The results indicate that we can generate secret bits at a rate of 7.15 bit/s, which is 44 percent faster than conventional text input PIN authentication.
Flexible Synthesen optisch aktiver Isocarbacycline (1989)

Potente und chemisch stabile Analoga des Hämostase‐Regulators Prostacyclin sind die Isocarbacycline, z. B. 1 , für deren biologische Aktivität die Struktur der Seitenketten ganz wesentlich ist. Schlüsselschritte neuer enantioselektiver Synthesen von Verbindungen des Typs 1 sind die radikalische Cyclisierung zum Bicyclo[3.3.0]octan‐Gerüst und γ‐Substitutionen zur Anbindung von „oberen”︁ Seitenketten unter Einführung der endocyclischen Doppelbindung. magnified image
Semantic Image Inpainting through Improved Wasserstein Generative Adversarial Networks (2019)

Image inpainting is the task of filling-in missing regions of a damaged or incomplete image. In this work we tackle this problem not only by using the available visual data but also by incorporating image semantics through the use of generative models. Our contribution is twofold: First, we learn a data latent space by training an improved version of the Wasserstein generative adversarial network, for which we incorporate a new generator and discriminator architecture. Second, the learned semantic information is combined with a new optimization loss for inpainting whose minimization infers the missing content conditioned by the available data. It takes into account powerful contextual and perceptual content inherent in the image itself. The benefits include the ability to recover large regions by accumulating semantic information even it is not fully present in the damaged image. Experiments show that the presented method obtains qualitative and quantitative top-tier results in different experimental situations and also achieves accurate photo-realism comparable to state-of-the-art works.
Ferrite materials (1950)

In Section 1.1 it is argued that ferromagnetic materials with a high resistivity are of considerable practical importance. In Section 1.2 the electric and magnetic properties of ferrite materials at various frequencies are discussed. In Section 1.3 an account is given of the physicochemical background of the properties of ferrites. In Section 1.4 the manufacture is dealt with and the important possibilities for application of different ferrite materials are briefly reviewed. In the following Sections 2.1–2.5 the experimental methods are described which are used for themeasurements of the electric and magnetic properties of the materials. Section 2.2 deals with a bridge used at frequencies between 1 and 100 kc/s. Sections 2.3 and 2.4 contain a description of themethods used for measurements at frequencies up to 500 Mc/s, while Section 2.5 deals with experiments in the microwave region.
Conflict resolving system among integrated services in home network system (2011)

In the near future, home network system controls appliances to achieve more convenient way of living. If plural services are executed simultaneously in home network system, they cause interaction problems that need to be resolved. This paper discusses how to detect and solve interaction problems. We define cause patterns for interaction problems. We introduce a service priority, restart flag, and interrupt disable flag to remove interaction problems.
High-performance MAC for high-capacity wireless LANs (2005)

The next-generation wireless technologies, e.g., 802.11n and 802.15.3a, offer a physical-layer speed at least an-order-of-magnitude higher than the current standards. However, direct application of current MACs leads to high protocol overhead and significant throughput degradation. We propose ADCA, a high-performance MAC that works with high-capacity physical layer. ADCA exploits two ideas of adaptive batch transmission and opportunistic selection of high-rate hosts to simultaneously reduce the overhead and improve the aggregate throughput. It opportunistically favors high-rate hosts by providing higher access probability and more access time, while ensuring each low-rate host certain minimum amount of channel access time. Simulations show that the ADCA design increases the throughput by 112% and reduces the average delay by 55% compared with the legacy DCF. It delivers more than 100 Mbps MAC-layer throughput as compared with 35 Mbps offered by the legacy MAC.
Counterimmunoelectrophoresis of pneumococcal antigens:improved sensitivity for the detection of types VII and XIV (1975)

Rapid identification of Streptococcus pneumoniae has been reported using counterimmunoelectrophoresis for the detection of specific capsular antigens in serum, cerebrospinal fluid, and urine. Previous clinical studies have failed to detect type VII or XIV pneumococcal antigen. These two types, however, account for a significant portion of pneumococcal disease. The incorporation of a sulfonated derivative of phenylboronic acid in the buffer system provides a method for the sensitive detection of these types in artificial mixtures without greatly reducing the sensitivity for the detection of other pneumococcal types. A problem with false positives encountered using human serum and barbitalbuffer was reduced by the use of buffer containing sulfonated phenylboronic acid.
A data-level database inference detection system (1998)

A Data Level Database Inference Detection System by Raymond Wai-Man Yip Doctor of Philosophy in Computer Science University of California at Davis Professor Karl Levitt, Chair Inference is a technique a user can employ to defeat access control mechanisms in a database system. It poses a con#dentiality threat to a database system, making it di#cult to control access to sensitive information. An inference detection system is needed to determine if users can use legitimately accessed data to infer sensitive information. The design of an inference detection system is a trade-o# among soundness, completeness, accessibility of the database, and e#ciency of the inference detection process. We describe six inference rules to determine if an adversary has collected enough data to perform inference, namely split query, subsume, unique characteristic, overlapping, complementary, and functional dependency. We prove our detection system is sound, thus it will not object to legitimate queries. Schema-based inference detection systems, which detect inference using functional dependencies, are unsound and incomplete, that is, they can generate false positives and negatives. Our system makes use of the database contents to detect inferences, making it more complete than schema-based inference detection systems. In this respect, our inference detection system detects a known inference attack called Tracker, not detectable by the schema-based approach. Our detection system can be ine#cient, as we need to keep track of all queries issued by users, and perform inference detection using them. A performance evaluation of our prototype shows that the system performance is a#ected by the size of the database, the amount of duplication of data in the database, the number of projected attri...
Development of an ordered microarray of electrochemiluminescent nanosensors (2006)

A microarray of electrochemiluminescent (ECL) nanosensors for remote detection is reported. Such nanosensor arrays were created on the distal face of coherent optical fibre bundles by adapting near-field optical probe and nanoelectrode methodologies. The fabrication process allows the production of high-density microarrays of nanosensors where each optical aperture is surrounded by a gold nanoring electrode. The initial architecture of the optical fibre bundle is retained and thus the microarray keeps its imaging properties. The electrochemical response of the array displays a steady-state current. This feature indicates that the nanoelectrodes forming the array can be considered as diffusively independent. In other words, each ring-shaped electrode of the array probes electrochemically a different micro-environment. We also show that this microdevice can be used as an ECL nanosensor microarray. Indeed, ECL light is initiated by the gold nanoring electrode in the presence of a co-reactant biospecies, NADH. A fraction of the isotropically electrochemically generated light is collected by the same aperture, transmitted by the corresponding fibre core and eventually imaged by a CCD camera. The gold coating therefore acts as an electrode material and also to confine the ECL light in each etched core. Such nanostructured microdevice integrates ECL-light generation, collection and imaging in a microarray format.
Food Powder Characteristics Important to Nonelectrostatic and Electrostatic Coating and Dustiness (2002)

ABSTRACT: Corn starch, maltodextrin, powdered sugar, cellulose, soy flour, corn flour, wheat flour, cocoa, nonfat dry milk, and salt were coated at 0, 19, and 25 kV using corona particle charging. Particle size, powder charge, density, and flow characteristics (flow index, cohesiveness, angle of repose, Hausner ratio) were correlated to coating efficiency and dustiness. Nonelectrostatic coating efficiency improved with large particle size, small powder charge, and low cohesiveness. Electrostatic coating at 25 kV improved with small particle size, low flow index, and high particle density. Dustiness decreased with large particle size‐particle density interaction, high flow index, and low cohesiveness. Electrostatics improved coating efficiency 68% and decreased dustiness 65% (excluding largest salt).
LDL-cholesterol signaling induces breast cancer proliferation and invasion (2014)

Lipids and cholesterol in particular, have long been associated with breast cancer (BC) onset and progression. However, the causative effects of elevated lipid levels and breast cancer remain largely undisclosed and were the subject of the present study.We took advantage of well-established in vitro and in vivo models of cholesterol enrichment to exploit the mechanism involved in LDL-cholesterol favouring BC growth and invasiveness. We analyzed its effects in models that mimic different BC subtypes and stages.Our data show that LDL-cholesterol (but not HDL-cholesterol) promotes BC cells proliferation, migration and loss of adhesion, hallmarks of the epithelial to mesenchymal transition. In vivo studies modeling cholesterol levels showed that breast tumors are consistently larger and more proliferative in hypercholesterolemic mice, which also have more frequently lung metastases. Microarray analysis revealed an over expression of intermediates of Akt and ERK pathways suggesting a survival response induced by LDL, confirmed by WB analyses. Gene expression analysis also evidenced an activation of ErbB2 signaling pathway and decreased expression of adhesion molecules (cadherin-related family member3, CD226, Claudin 7 and Ocludin) in the cells exposed to LDL.Together, the present work shows novel mechanistic evidence that high LDL-cholesterol levels promote BC progression. These data provide rationale for the clinical control of cholesterol levels in BC patients.