gebhart/patrepeval huggingface dataset:
The Positive Regulation of p53 by the Tumor Suppressor VHL (2006)

The ubiquitin-mediated degradation of hypoxia-inducible factor-alpha (HIF-alpha) by a von Hippel-Lindau tumor suppressor protein (pVHL) is mechanistically responsible for controlling gene expression due to oxygen availability. Germline mutations in the VHL gene cause dysregulation of HIF and induce an autosomal dominant cancer syndrome referred to as VHL disease. However, it is unclear whether HIF accumulation caused by VHL mutations is sufficient for tumorigenesis. Recently, we found that pVHL directly associates and positively regulates the tumor suppressor p53 by inhibiting Mdm2-mediated ubiquitination, and by subsequently recruiting p53-modifying enzymes. Moreover, VHL-deleted RCC cells showed attenuated apoptosis or abnormal cell-cycle arrest upon DNA damage, but became normal when pVHL was restored. Thus, pVHL appears to play a pivotal role in tumor suppression by participating actively as a component of p53 transactivation complex during DNA damage response.
Image distortion from zoom lenses: modeling and digital correction (1992)

Television camera lenses and in particular variable focal length lenses (zoom lenses) are not perfect optical instruments. They provide images with two kinds of optical defects, geometric and chromatic aberration. For tube cameras, these distortion defects and the lateral chromatic aberration within the tube scan are corrected. In the case of CCD based systems this correction principle is no longer applicable. Even if the defects are negligible in current TV standards, they become important in HDTV and very high resolution image analysis. The authors propose a method of digital correction of distortion and lateral chromatic aberration effects before image processing and viewing.<
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Electron mobility in single and multiple period modulation-doped (Al,Ga)As/GaAs heterostructures (1982)

Single and multiple period modulation-doped (Al,Ga)As/GaAs heterostructures have been grown by molecular beam epitaxy (MBE) and characterized by Hall measurements. The basic structure consists of alternating layers of undoped GaAs and doped (Al,Ga)As separated by undoped ’’intrinsic’’ layers of (Al,Ga)As. The thickness of each of these layers was varied independently in a one, three, or nine period structure. Mobilities as high as 211 000, 95 500, and 8 360 cm2V−1 s−1 were obtained at 10 K, 78 K, and 300 K, respectively. The total sheet charge concentrations were about 2.25×1012 cm−2 in the highest mobility structures. Single period structures with an AlAs mole fraction of 0.33 typically had higher room-temperature mobilities while multiple period structures with an AlAs mole fraction of 0.2 gave better results at cryogenic temperatures. The enhanced mobilities are attributed to the separation of electrons and donors by the undoped (Al,Ga)As layers and the high quality interfaces obtainable by MBE. To our knowledge, these results on single and multiple period structures are comparable to the best values reported to date.
Essentia: An Audio Analysis Library For Music Information Retrieval. (2013)

[TODO] Add abstract here.
CNN based Patch Matching for Optical Flow with Thresholded Hinge Loss. (2016)

Learning based approaches have not yet achieved their full potential in optical flow estimation, where their performance still trails heuristic approaches. In this paper, we present a novel optical flow pipeline that uses patch-matching with CNN trained features at multiple scales. We show a novel way for calculating CNN based features for different scales, which performs better than existing methods. Furthermore, we introduce a new thresholded loss for Siamese networks and demonstrate that our novel loss performs clearly better than existing losses. It also allows to speed up training by a factor of 2 in our tests. Moreover, we discuss new ways of evaluating the robustness of trained features for the application of patch matching for optical flow. An interesting discovery in our paper is that low pass filtering feature maps can increase the robustness of features created by CNNs. We prove competitive performance of our approach by submitting it to the KITTI 2012 and KITTI 2015 evaluation portals and obtaining the best results on KITTI 2012 and the best for foreground objects in KITTI 2015.
The Manufacture of Porous Ceramics Using Supercritical Co2. (2008)

A process has been developed where supercritical fluid technology has been utilised to manufacture porous ceramic components. by using highly compressed carbon dioxide sintered ceramic components have been manufactured using ceramic powder shaping techniques such as extrusion and injection moulding. This paper will exemplify the development of a versatile, clean process, which is applicable to a wide range of binder systems and ceramic powders. the research has led to the production of sintered ceramic components with controlled porosity, which was found to be dependent on the rheology of the material formulation and process conditions during shaping.
Recent achievements of AlInGaN based laser diodes in blue and green wavelength (2007)

AlInGaN based blue and blue-green LDs were investigated with regard to the characteristics of GaN semiconductor laser diodes. High power, single mode blue LDs with high COD level (~334mW under CW operation at 25°C, kink-free at 150mW) and long lifetime (~10000 hours under CW operation, 50mW 25°C) were achieved. No significant characteristic differences between blue LDs on LEO-GaN/sapphire and GaN substrate were observed. The blue-green LD which has the wavelength of 485 nm was successfully fabricated and demonstrated under CW operation 25°C, while it showed poor performances of LD characteristics compared to those of blue LDs. We believe that the poor performance of blue-green LDs were caused by the piezo-electric effect by lattice mismatch along C-axis of GaN, In fluctuation by lattice mismatch and In solubility limit in InGaN QWs and thermal annealing which was performed during the p-layer growth.
Endothelial Dysfunction in Shock States (1993)

Circulatory shock results in dysfunction of the endothelium in various vascular beds. This dysfunction is characterized by marked impairment in the vasculature's ability to relax to endothelium-dependent vasodilators. This loss of endothelium-derived relaxing factor, or nitric oxide, leads to profound tissue injury.
A family of predictive constant modulus algorithms for blind equalization (2002)

In this work we present a family of predictive constant modulus algorithms that performs blind equalization with some advantages over the CMA/FIR conventional technique. The LMS-like algorithm of the family (PCMA) was originally presented by Cavalcanti and Mota (1997). In this paper we present two new algorithms based in the same approach: the normalized PCMA (NPCMA) and the recursive PCMA (RPCMA). The choice of one of these algorithms depends on a compromise between performance and complexity, as usual. Simulation results confirm that PCMA-based algorithms perform better than conventional FIR equalizers in terms of steady-state error. Moreover, the proposed NPCMA and RPCMA provides increased convergence speed when compared to the original PCMA.
Proactive flight schedule evaluation at Delta Air Lines (1999)

Delta Air Lines is the first and only airline to carry over 100 million passengers in a year, carrying over 105,000,000 passengers in 1998. To provide service to this number of passengers, Delta operates a "hub and spoke" flight system. In the hub and spoke system, certain key airports, or hubs, are designated as the origination point of a large number of flights, thereby allowing a passenger departing from a hub airport almost unlimited flexibility in terms of direct flight destinations. A change in the operation of the runways in one of Delta's hub airports was planned, and Delta management wanted to determine the effect on the dependable operation of the current and future flight schedules.
Scatter Compensation in Digital Chest Radiography Using Fourier Deconvolution (1989)

The authors present a numerical deconvolution technique to compensate for image degrading effects caused by scattered photons in radiographic chest images. Fourier transform techniques are used to deconvolve a shift invariant model of the two dimensional point spread response functions of the scattered radiation. This approach uses a digitized radiograph acquired with a standard chest imaging protocol, so no specialized imaging equipment is required. While the shift variant shape of the scatter model is optimized for the lung field, effective compensation is provided when this model shape is applied to other chest regions. Preliminary evaluation suggests that this technique can provide improved image contrast over the entire chest region.
Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells (2009)

Lin28 acts as a repressor of microRNA processing and as a post-transcriptional regulatory factor for a subset of mRNAs. Here we report that in human embryonic stem cells Lin28 facilitates the expression of the pivotal pluripotency factor Oct4 at the post-transcriptional level. We provide evidence that Lin28 binds Oct4 mRNA directly through high affinity sites within its coding region and that an interaction between Lin28 and RNA helicase A (RHA) may play a part in the observed regulation. We further demonstrate that decreasing RHA levels impairs Lin28-dependent stimulation of translation in a reporter system. Taken together with previous studies showing that RHA is required for efficient translation of a specific class of mRNAs, these findings suggest a novel mechanism by which Lin28 may affect target mRNA expression and represent the first evidence of post-transcriptional regulation of Oct4 expression by Lin28 in human embryonic stem cells.
Oil-Based Formulations for Oral Delivery of Therapeutic Peptides (2000)

A novel technology has been developed by which water-soluble substances ranging from simple inorganic salts to complex macromolecules, are solubilized in the absence of water, into organic liquids. The resulting microphases are quite different from any that have been previously described in the literature and can potentially be used for delivery of drugs and other materials via a range of routes, including oral, topical, pulmonary, nasal and ocular. The formulations are prepared using a liposomal methodology, and liposomes may also play a role in the ultimate delivery of the drug. This presentation describes the manufacture and properties of the formulations, and presents data for their use in delivering insulin and calcitonin in vivo, using the juvenile pig model.
Winnowing-based text clustering (2008)

We present an approach to document clustering based on winnowing fingerprints that achieved good values of effectiveness with considerable save in memory space and computation time.
Fetal Death and Reduced Birth Rates Associated with Exposure to Lead-Contaminated Drinking Water (2013)

This ecologic study notes that fetal death rates (FDR) during the Washington DC drinking water "lead crisis" (2000-2004) peaked in 2001 when water lead levels (WLLs) were highest, and were minimized in 2004 after public health interventions were implemented to protect pregnant women. Changes in the DC FDR vs neighboring Baltimore City were correlated to DC WLL (R(2) = 0.72). Birth rates in DC also increased versus Baltimore City and versus the United States in 2004-2006, when consumers were protected from high WLLs. The increased births in DC neighborhoods comparing 2004 versus 2001 was correlated to the incidence of lead pipes (R(2) = 0.60). DC birth rates from 1999 to 2007 correlated with proxies for maternal blood lead including the geometric mean blood lead in DC children (R(2) = 0.68) and the incidence of lead poisoning in children under age 1.3 years (R(2) = 0.64). After public health protections were removed in 2006, DC FDR spiked in 2007-2009 versus 2004-2006 (p < 0.05), in a manner consistent with high WLL health risks to consumers arising from partial lead service line replacements, and DC FDR dropped to historically low levels in 2010-2011 after consumers were protected and the PSLR program was terminated. Re-evaluation of a historic construction-related miscarriage cluster in the USA Today Building (1987-1988), demonstrates that high WLLs from disturbed plumbing were a possible cause. Overall results are consistent with prior research linking increased lead exposure to higher incidence of miscarriages and fetal death, even at blood lead elevations (≈5 μg/dL) once considered relatively low.
Membrane Potential Changes in Dendritic Spines during Action Potentials and Synaptic Input (2009)

Excitatory input onto many neurons in the brain occurs onto specialized projections called dendritic spines. Despite their potential importance in neuronal function, direct experimental evidence on electrical signaling in dendritic spines is lacking as their small size makes them inaccessible to standard electrophysiological techniques. Here, we investigate electrical signaling in dendritic spines using voltage-sensitive dye imaging in cortical pyramidal neurons during backpropagating action potentials and synaptic input. Backpropagating action potentials were found to fully invade dendritic spines without voltage loss. The voltage change in dendritic spines during synaptic input ranged from a few millivolts up to approximately 20 mV. During hyperpolarization of the membrane potential, the amplitude of the synaptic voltage in spines was increased, consistent with the expected change resulting from the increased driving force. This observation suggests that voltage-activated channels do not significantly boost the voltage response in dendritic spines during synaptic input. Finally, we used simulations of our experimental observations in morphologically realistic models to estimate spine neck resistance. These simulations indicated that spine neck resistance ranges up to approximately 500 Mohms. Spine neck resistances of this magnitude reduce somatic EPSPs by <15%, indicating that the spine neck is unlikely to act as a physical device to significantly modify synaptic strength.
Correlating backbone amide and side chain resonances in larger proteins by multiple relayed triple resonance NMR (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrelating backbone amide and side chain resonances in larger proteins by multiple relayed triple resonance NMRStephan Grzesiek and Ad BaxCite this: J. Am. Chem. Soc. 1992, 114, 16, 6291–6293Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://doi.org/10.1021/ja00042a003RIGHTS & PERMISSIONSArticle Views1470Altmetric-Citations799LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (389 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Cyclopolymerisation einiger glutardialdehyde. Struktur der polymeren (1962)

Abstract Die löslichen Spontanpolymerisate des Glutardialdehyds, β‐Methyl‐ und β‐Phenylglutardialdehyds bestehen auf Grund ihrer Eigenschaften und IR‐Spektren vornehmlich aus Tetrahydropyranstruktureinheiten, die durch eine Cyclopolymerisation gebildet werden. Es wird ein infrarotspektroskopischer Vergleich mit verschiedenen niedermolekularen Tetrahydropyran‐Modellsubstanzen durchgeführt. Die unkatalysierte Polymerisation läßt sich infrarotspektroskopisch verfolgen. Die Poly‐glutardialdehyde können acetyliert werden. Die Polymeren erfahren durch die Acetylierung eine wesentliche thermische Stabilisierung. Die Eigenschaften und IR‐Spektren der Spontanpolymerisate werden mit denen des vernetzten Poly‐glutardialdehydes verglichen, der mittels einer katalysierten Polymerisation hergestellt wird.
Western immunoblot analysis of Haemobartonella muris and comparison of 16S rRNA gene sequences of H. muris, H. felis, and Eperythrozoon suis (1997)

Infectious agents were isolated from the spleens of three wild mice (Apodemus argenteus) by intraperitoneal inoculation of the spleen homogenate into laboratory mice. The laboratory mice developed clinical signs and splenomegaly, and three isolates were maintained by passage in mice. Tetracyclines were effective in preventing infection of mice with these agents, but streptomycin and penicillin were ineffective. The agents did not grow in bacterial growth media or chicken embryos. In smears of blood from infected mice stained by the Giemsa or the indirect immunofluorescence method, numerous organisms were found on the surfaces of erythrocytes. Electron microscopy revealed cell wall-less pleomorphic cocci of 350 to 700 nm in diameter. On the basis of these results, the isolates were identified as Haemobartonella muris. There was no antigenic cross-reactivity with Rickettsia or Ehrlichia spp. or other related organisms. Western immunoblot analysis of three strains of H. muris with mouse antisera to H. muris revealed identical major antigens of 118, 65, 53, 45, and 40 kDa. By heteroduplex analysis of the three PCR-amplified segments of the 16S rRNA genes, the three strains of H. muris were found to be identical. The 16S rRNA genes of one of the H. muris strains, four strains of H. felis, and two strains of Eperythrozoon suis were sequenced and compared. The sequences of two strains of H. felis from cats in California were identical, as were the sequences of a strain from a cat in Ohio and a strain from a cat in Florida, but the similarity of sequences between the California and the Ohio-Florida strains was only 85%. The sequence of an H. muris strain was unique and was more closely related to that of the Ohio-Florida strain of H. felis (89%) than to that of the California strain of H. felis (84%). The sequence of E. suis from a pig in Illinois was identical to that from another pig from Taiwan. The similarity of the 16S rRNA gene sequence of E. suis with those of three Haemobartonella strains was 84 to 92%, with that of E. suis being most similar to that of the H. felis strain from California. In the phylogenetic analysis based on 16S rRNA gene sequences, the Haemobartonella spp. and E. suis formed a distinct clade more closely related to Mycoplasma spp. (79 to 83% similarity) than to Anaplasma marginale (72 to 75% similarity). Our results suggest that the Haemobartonella spp. and E. suis may be reclassified in the same genus in the family Mycoplasmataceae.
Prostate specific antigen and prostatitis I. Effect of prostatitis on serum psa in the human and nonhuman primate (1992)

Prostate specific antigen (PSA) has become a mainstay in the diagnosis and management of patients with prostate cancer. We have found, as have others, that it may be elevated in patients with prostatic inflammation. Ten patients had clinical evidence of prostatitis and elevated PSA levels. Six of these had persistently elevated levels after antibiotic treatment. After transrectal ultrasonography and biopsy, two had findings of adenocarcinoma, and the rest had a pathologic diagnosis of acute or chronic prostatitis. We studied this process in an experimental model of prostatitis using a nonhuman primate. We infected six cynomolgus monkeys and followed their PSA levels until resolution of the infection. The PSA peaked between 5 and 7 days after inoculation and gradually returned to baseline in 8 weeks. The dramatically elevated serum PSA levels in bacterial prostatitis can cause confusion in the diagnosis of prostatic carcinoma.
Signal Processing Approaches to Minimize or Suppress Calibration Time in Oscillatory Activity-Based Brain–Computer Interfaces (2015)

One of the major limitations of brain-computer interfaces (BCI) is their long calibration time, which limits their use in practice, both by patients and healthy users alike. Such long calibration times are due to the large between-user variability and thus to the need to collect numerous training electroencephalography (EEG) trials for the machine learning algorithms used in BCI design. In this paper, we first survey existing approaches to reduce or suppress calibration time, these approaches being notably based on regularization, user-to-user transfer, semi-supervised learning and a priori physiological information. We then propose new tools to reduce BCI calibration time. In particular, we propose to generate artificial EEG trials from the few EEG trials initially available, in order to augment the training set size. These artificial EEG trials are obtained by relevant combinations and distortions of the original trials available. We propose three different methods to do so. We also propose a new, fast and simple approach to perform user-to-user transfer for BCI. Finally, we study and compare offline different approaches, both old and new ones, on the data of 50 users from three different BCI data sets. This enables us to identify guidelines about how to reduce or suppress calibration time for BCI.
Conjugated Linoleic Acid Reduces Body Fat in Healthy Exercising Humans (2001)

This study was designed to investigate the efficacy and tolerability of daily conjugated linoleic acid (CLA) in healthy exercising humans. This was a randomized, double-blind, placebo-controlled study in 20 healthy humans of normal body weight and body mass index less than 25.0 kg/m 2 , who did standardized physical exercise in a gym for 90 min three times weekly. Participants took either placebo (hydrogel) or CLA 0.6 mg, three times daily, as two capsules during meals, for 12 weeks. Body fat, measured using near infrared light, was significantly reduced in the CLA group during the study, but not in the placebo group. No effects on body weight were observed. Tolerability was good and similar in the two groups. Compliance, as judged by the number of returned capsules, was more than 80% of the recommended dose for all participants. Thus CLA reduces body fat but not body weight in healthy exercising humans of normal body weight.
Highly efficient polymer light-emitting devices using ambipolar phosphorescent polymers (2005)

We report on highly efficient polymer light-emitting devices (PLEDs) achieved using a phosphorescent polymer, which is a copolymer that has bis(2-phenylpyridine)iridium (acetylacetonate) [Ir(ppy)2(acac)], N,N′-diphenyl-N,N′-bis(3-methylphenyl)-[1,1′-biphenyl]-4,4′-diamine (TPD) and 2-(4-biphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (PBD) as a side group. The phosphorescent polymer has an ambipolar charge-transport ability. An increase in PBD unit concentration allows an improvement in the efficiency of the PLEDs. Ba and Cs were used for electron-injection layers as well as Ca, to improve the electron injection. An external quantum efficiency of 11.8% and a power efficiency of 38.6lm∕W were obtained by using Cs. The results indicate that this can be attributed to an improvement in the charge balance of electrons and holes.