gebhart/patrepeval huggingface dataset:
Gist of a Thread in Social Network Services Based on Credibility of Wikipedia (2011)

Users of Social Network Services(SNS) can sometimes enter into heated discussions, which prompt those users to concentrate on a single issue and lose track of the actual theme. We believe that it would be beneficial for users and visitors to present information to help understand the gist of the discussion at a glance. As described in this paper, we propose a system that presents a gist of a thread on an SNS and basic information about it by comparing the comments in the thread with Wikipedia article. Wikipedia articles, however, are not always credible. When we compare a thread on an SNS with Wikipedia, the Wikipeida article must have credible content. We measure the credibility of the article based on the credibility of Editors. We first extract the target passage which is candidate of the gist of a thread in an SNS based on the Wikipedia Table of Contents(TOC). Then we measure the credibility of editors of Wikipedia using the edit history and measure the credibility of the article using results of the credibility of editors. The target passage, which has a high similarity degree with comment in an SNS and has a high credibility rate becomes the gist of the thread in SNS. Consequently, users and viewers can ascertain the gist of an SNS thread by viewing a Wikipedia TOC with credibility.
Development of mobile-based hand vein biometrics for global health patient identification (2014)

For many health services in developing countries, patient identification is a fundamental need. In countries where no standard form of identification is available, this problem is exacerbated by a lack of literacy and also frequent errors in spelling and consistency. To address this need, we implemented two low-cost hand vein scanner devices for use with mobile devices. The first scanner device employs the internal camera of the an Android smart phone along with a rechargeable infrared light (850nm) and an external optical filter; and the second scanner device employs a low-cost webcam, with integrated LEDs (940nm) and optical filter, which is powered directly from the Android tablet. A single mobile app was developed for use with both scanner devices with the ability to adjust scanner settings, capture hand palm images, and annotate patient data. As an initial test of our scanner designs, we collected hand scans from 51 university students aged 18-34 using an IRB-approved protocol, and data was processed using a 2D-PCA biometric algorithm implemented on a PC using MATLAB software. Using the standard FAR-FRR curve for biometric analysis, we were able to achieve an Equivalent Error Rate (EER) of 6.3% for the phone camera scanner, and 4.2% for the webcam scanner design. These results compare favorably with other published biometrics studies and demonstrate the potential of low-cost biometric devices that can be integrated with mobile phones and tablets.
Aminopeptidase N from <i>Bombyx Mori</i> as a Candidate for the Receptor of Bacillus Thuringiensis Cry1Aa Toxin (1997)

Cry1Aa toxin-binding proteins from the midgut brush border membrane vesicles of Bombyx mori, a toxin-susceptible silkworm, were analyzed to find candidates for the toxin receptors. Ligand blotting showed that Cry1Aa toxin bound to a 120-kDa protein. A part of the 120-kDa protein was solubilized from the membrane vesicles with phosphatidylinositol-specific phospholipase C, resulting in a 110-kDa protein which therefore may be linked to a glycosyl-phosphatidylinositol anchor. The 120-kDa and 110-kDa Cry1Aa toxin-binding proteins were solubilized with detergent or pohosphatidylinositol-specific phospholipase C, respectively, and purified using anion-exchange chromatography. Scatchard plot analysis for the specific binding of purified 110-kDa protein to Cry1Aa toxin yielded a Kd value of 7.6 nM, which was similar to that for the binding of intact brush border membrane vesicles to the toxin. N-terminal and internal amino acid sequences of the 120-kDa and 110-kDa proteins showed high degrees of similarity to those of aminopeptidase N, a putative Cry1Ac toxin receptor, reported in Manduca sexta and Heliothis virescens. On this basis, the 120-kDa Cry1Aa toxin-binding protein from B. mori was identified as a member of the aminopeptidase family.
Preparation of Sulfhydryl Cyclosporin A (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of Sulfhydryl Cyclosporin AMarcel K. Eberle, Francois Nuninger, and Hans-Peter WeberCite this: J. Org. Chem. 1995, 60, 8, 2610–2612Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/jo00113a046https://doi.org/10.1021/jo00113a046research-articleACS PublicationsRequest reuse permissionsArticle Views172Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Grid coding: a preprocessing technique for robot and machine vision (1971)

ABSTRACT: The problem of machine vision as evidenced In the various robot projects in existence is attacked by analogy with the supposed nature of human visual processing in that edges are enhanced, texture is examined and various heuristic approaches are studied. This paper describes a non-anthropomorphically based method of decomposing a scene subjected to a special form of illumination into elementary planar areas. The method consists in coding the various planar areas as the modulation on a spatial frequency carrier grid so that the extraction of the planar areas becomes a matter of linear frequency domain filtering. The paper also addresses the application of grid coding to other problems in recording and extracting information from 3-D images.
Increased expression of platelet‐derived growth factor type b receptors in the skin of patients with systemic sclerosis (1990)

The expression of B-type receptors for platelet-derived growth factor (PDGF) was investigated in skin biopsy samples from patients with systemic sclerosis (SSc), by immunohistochemical staining using monoclonal antibodies specific for the receptor. Whereas skin from healthy individuals lacked expression of PDGF-B receptors, receptor expression was seen in sclerodermatous skin lesions from 13 of 14 patients. Increased receptor expression was observed in dermal vessels, as well as on many stromal fibroblast-like cells close to these vessels. PDGF-B receptor expression was most pronounced within and around dermal vessels in which perivascular infiltrates of Leu-4-positive T lymphocytes and HLA-DR-positive, RFD7-positive activated macrophages were present. Both perivascular inflammatory cell infiltrates and PDGF-B receptor expression were generally also seen in macroscopically normal areas of the skin of the SSc patients, indicating that the observed phenotypic alterations may precede the macroscopically observable features of scleroderma in the skin. The observed induction of PDGF-B receptors, together with indirect indications of increased synthesis and release of PDGF, would be compatible with altered PDGF-mediated control of connective tissue cell growth as part of the molecular basis for development of the skin lesions in SSc.
Enabling Secure and Efficient Ranked Keyword Search over Outsourced Cloud Data (2011)

Cloud computing economically enables the paradigm of data service outsourcing. However, to protect data privacy, sensitive cloud data have to be encrypted before outsourced to the commercial public cloud, which makes effective data utilization service a very challenging task. Although traditional searchable encryption techniques allow users to securely search over encrypted data through keywords, they support only Boolean search and are not yet sufficient to meet the effective data utilization need that is inherently demanded by large number of users and huge amount of data files in cloud. In this paper, we define and solve the problem of secure ranked keyword search over encrypted cloud data. Ranked search greatly enhances system usability by enabling search result relevance ranking instead of sending undifferentiated results, and further ensures the file retrieval accuracy. Specifically, we explore the statistical measure approach, i.e., relevance score, from information retrieval to build a secure searchable index, and develop a one-to-many order-preserving mapping technique to properly protect those sensitive score information. The resulting design is able to facilitate efficient server-side ranking without losing keyword privacy. Thorough analysis shows that our proposed solution enjoys “as-strong-as-possible” security guarantee compared to previous searchable encryption schemes, while correctly realizing the goal of ranked keyword search. Extensive experimental results demonstrate the efficiency of the proposed solution.
Autonomous management of cost, performance, and resource uncertainty for migration of applications to infrastructure-as-a-service (IaaS) clouds (2007)

Infrastructure-as-a-Service (IaaS) clouds abstract physical hardware to provide computing resources on demand as a software service. This abstraction leads to the simplistic view that computing resources are homogeneous and infinite scaling potential exists to easily resolve all performance challenges. Adoption of cloud computing, in practice however, presents many resource management challenges forcing practitioners to balance cost and performance tradeoffs to successfully migrate applications. These challenges can be broken down into three primary concerns that involve determining what, where, and when infrastructure should be provisioned. In this dissertation we address these challenges including: (1) performance variance from resource heterogeneity, virtualization overhead, and the plethora of vaguely defined resource types; (2) virtual machine (VM) placement, component composition, service isolation, provisioning variation, and resource contention for multitenancy; and (3) dynamic scaling and resource elasticity to alleviate performance bottlenecks. These resource management challenges are addressed through the development and evaluation of autonomous algorithms and methodologies that result in demonstrably better performance and lower monetary costs for application deployments to both public and private IaaS clouds. This dissertation makes three primary contributions to advance cloud infrastructure management for application hosting. First, it includes design of resource utilization models based on step-wise multiple linear regression and artificial neural networks that support prediction of better performing component compositions. The total number of possible compositions is governed by Bell's Number that results in a combinatorially explosive search space. Second, it includes algorithms to improve VM placements to mitigate resource heterogeneity and contention using a load-aware VM placement scheduler, and autonomous detection of under-performing VMs to spur replacement. Third, it describes a workload cost prediction methodology that harnesses regression models and heuristics to support determination of infrastructure alternatives that reduce hosting costs. Our methodology achieves infrastructure predictions with an average mean absolute error of only 0.3125 VMs for multiple workloads.
Sound collection systems using a crowdsourcing approach to construct sound map based on subjective evaluation (2016)

This paper presents a sound collection system that uses crowdsourcing to gather information for visualizing area characteristics. First, we developed a sound collection system to simultaneously collect physical sounds, their statistics, and subjective evaluations. We then conducted a sound collection experiment using the developed system on 14 participants. We collected 693,582 samples of equivalent A-weighted loudness levels and their locations, and 5,935 samples of sounds and their locations. The data also include subjective evaluations by the participants. In addition, we analyzed the changes in sound properties of some areas before and after the opening of a large-scale shopping mall in a city. Next, we implemented visualizations on the server system to attract users' interests. Finally, we published the system, which can receive sounds from any Android smartphone user. The sound data were continuously collected and achieved a specified result.
No association between apolipoprotein E epsilon 4 allele and rate of decline in Alzheimer's disease (1997)

Although the APOE epsilon 4 allele is a risk factor for Alzheimer's disease, there is no support of a strong association between APOE epsilon 4 dosage and rate of cognitive decline. The epsilon 4 allele did not predict age at onset. Methodological inconsistencies may account for discrepancies between these results and previous findings.
Biosafety of Recombinant Adeno-associated Virus Vectors (2014)

It is hoped that the use of gene transfer technology to treat both monogenetic and acquired diseases may soon become a common therapy option in medicine. For gene therapy to achieve this objective, any gene delivery method will have to meet several criteria, including ease of manufacturing, efficient gene transfer to target tissue, long-term gene expression to alleviate the disease, and most importantly safety in patients. Viral vectors are an attractive choice for use in gene therapy protocols due to their relative efficiency in gene delivery. Since there is inherent risk in using viruses, investigators in the gene therapy community have devoted extensive efforts toward reengineering viral vectors for enhance safety. Here we review the approaches and technologies that are being evaluated for the use of recombinant vectors based upon adeno-associated virus (AAV) in the treatment of a variety of human diseases. AAV is currently the only known human DNA virus that is non-pathogenic and AAV-based vectors are classified as Risk Group 1 agents for all laboratory and animal studies carried out in the US. Although its apparent safety in natural infection and animals appears well documented, we examine the accumulated knowledge on the biology and vectorology of AAV, lessons learned from gene therapy clinical trials, and how this information is impacting current vector design and manufacturing with an overall emphasis on biosafety.
Aβ<sup>1-40</sup> Peptide Radiopharmaceuticals for Brain Amyloid Imaging:  <sup>111</sup>In Chelation, Conjugation to Poly(ethylene glycol)-Biotin Linkers, and Autoradiography with Alzheimer's Disease Brain Sections (2000)

The amyloid plaques of Alzheimer's disease (AD) are formed by the neuropeptide Abeta(1)(-)(42/43), and carboxyl terminal truncated forms of this neuropeptide, designated Abeta(1)(-)(40), bind to amyloid plaques of AD autopsy tissue sections. Therefore, Abeta(1)(-)(40) is a potential peptide radiopharmaceutical that could be used for imaging brain amyloid in living subjects with AD, should this neuropeptide be made transportable through the blood-brain barrier (BBB). To accomplish this, the neuropeptide must be modified to enable (i) attachment to a BBB drug targeting system and (ii) labeling with a radionuclide, e.g., 111-indium, suitable for brain imaging by external detection modalities such as single photon emission computed tomography (SPECT). The present studies describe the synthesis of an Abeta(1)(-)(40) analogue that contains a biotin at the amino terminus and a diethylenetriaminepentaacetic acid (DTPA) moiety conjugated to one of the internal lysine residues. The DTPA-[N-biotin]-Abeta(1)(-)(40) was purified by gel filtration fast-protein liquid chromatography (FPLC) using two Superose 12HR columns in series, and the structure of the purified peptide was confirmed by matrix-assisted laser desorption ionization (MALDI) mass spectrometry. The binding of the [(111)In]DTPA-[N-biotin]-Abeta(1)(-)(40) to amyloid plaques of AD autopsy tissue sections was demonstrated by film and emulsion autoradiography. A poly(ethylene glycol) (PEG) linker of 3400 Da molecular mass, designated PEG(3400), was inserted between the Abeta(1)(-)(40) and the biotin moiety, but this modification diminishes binding of Abeta(1)(-)(40) to the AD amyloid plaques. In summary, these studies describe a novel formulation of biotinylated Abeta(1)(-)(40) that allows radiolabeling with 111-indium. The peptide radiopharmaceutical may be conjugated to an avidin-based BBB drug targeting system to enable transport through the BBB and imaging of brain amyloid in vivo.
Synthesis and biochemical evaluation of (R)-5-acyloxymethyl- and (S)-5-acylaminomethyl-3-(1H-pyrrol-1-yl)-2-oxazolidinones as new anti-monoamine oxidase (anti-MAO) agents (2004)

R)-5-Acyloxymethyl-and (S)-5-acylaminomethyl-3-(1H-pyrrol-1-yl)-2-oxazolidinones 2a-s were synthesized as pyrrole analogues of toloxatone (Humoryl ), an anti-MAO agent used in clinical therapy because of its antidepressant properties. Their ability to inhibit the enzymatic isoforms MAO-A and MAO-B was evaluated. From the data most 2a-s showed high reversibility and selective MAO-A inhibitory activity. They exhibited an inhibitory potency (K iMAO-A ) of 0.16-0.90 M comparable to that found for toloxatone (K iMAO-A = 0.38 M), the A isoform being 11-fold more selective. The results indicate that 2a-s show promise as new antidepressant agents.
Azithromycin Compared with Minocycline in the Treatment of Acne Comedonica and Papulo-Pustulosa (1998)

This open study was conducted in 72 outpatients with acne vulgaris, to compare the clinical efficacy and tolerability of azithromycin and minocycline. Azithromycin was administered as a single oral dose (500 mg/day) for 4 days in four cycles every 10 days and minocycline was administered 100 mg daily for 6 weeks. Improvement was assessed 6 weeks after initiation of treatment with a four-graded scale. A satisfactory clinical response was observed in 75.8% of the patients treated with azithromycin and in 70.5% of those treated with minocycline. There were no significant differences between these two acne treatments in terms of reduction of the number of lesions (p> 0.05). Both agents were well tolerated and mild side effects were reported in 10.3% of azithromycin and 11.7% of minocycline treated patients. We conclude that azithromycin is at least as clinically effective and well tolerated as minocycline as treatment of facial comedonic and papulopustular acne.
Investigational drugs for eating disorders (1997)

AbstractAnorexia nervosa (AN), bulimia nervosa (BN) and binge eating disorder (BED) each occur in about 0.5 - 1.5% of the population in westernised countries, and primarily affect women. At present, a variety of pharmacological treatments are used in addition to psychotherapy, with antidepressants being most the common. Currently available drugs, while helpful, fall far short of desired levels of efficacy. Based on current knowledge about neural mechanisms that regulate feeding behaviour, several classes of compounds are in development to treat eating disorders. These include cholecystokinin (CCK) antagonists, corticotropin-releasing hormone (CRH) antagonists, histamine-3 (H3) receptor antagonists, neuropeptide Y (NPY) antagonists, and a variety of serotonin uptake inhibiting drugs. Based on currently available effective treatments, it seems reasonable that the serotonin uptake inhibiting drugs might hold the greatest likelihood of benefit for these illnesses, but the receptor antagonists in development might provide substantial improvement in response rates.Keywordsanorexia nervosabinge eating disorderbulimia nervosacholecystokinincorticotropin-releasing hormoneeating disordershistamine-3 receptorneuropeptide Yserotonin
Targeting 11β-hydroxysteroid dehydrogenase type 1 in brain: therapy for cognitive aging? (2006)

Dementia care costs exceed those of cardiovascular diseases and cancer combined. Milder forms of functionally significant cognitive decline add further to the staggering human, societal and economic costs. However, the underlying mechanisms are poorly understood and few treatments are available. Cumulative exposure to high glucocorticoid levels is a major hypothesis of decline in cognitive function with aging. Current manipulations to maintain low circulating glucocorticoid levels throughout life (adrenalectomy with low-dose corticosterone replacement and neonatal handling), although effective in preventing the emergence of memory deficits with age in rodent models, are not clinically applicable. By contrast, recent data in cells, mice and humans suggest that inhibition of the tissue-selective glucocorticoid-amplifying enzyme, 11β-hydroxysteroid dehydrogenase type 1, may be an effective novel approach.
Investigation of Doxorubicin Resistance in MCF-7 Breast Cancer Cells Using Shot-Gun Comparative Proteomics with Proteolytic <sup>18</sup>O Labeling (2004)

A shot-gun comparative proteomic investigation utilizing proteolytic 18O labeling has been carried out on a drug susceptible MCF-7 human breast cancer cell line and a related cell line that is resistant to doxorubicin. The proteolytic 18O labeling method has been further refined and optimized for application to a protein fraction stemming from the cytosol of the breast cancer cells. The comparative investigation revealed several proteins with altered expression levels in the doxorubicin resistant line. These altered proteins are considered for a possible role in doxorubicin resistance.
Techno-economic Analysis of MEA CO2 Capture from a Cement Kiln – Impact of Steam Supply Scenario (2017)

This paper present the techno-economic assessment of an MEA-based CO2 capture from a cement plant and the importance of the steam supply on the costs. The evaluations present the energy performances of the CO2 capture process based on a cement plant with a clinker capacity of 3,000 t/d. The cost evaluation lead to a cost of cement of 45 €/tcement without capture, while the cost of cement with CO2 capture is estimated to 81 €/tcement, resulting in a CO2 avoided cost of 83 €/tCO2,avoided. As the steam consumption accounts for close to half of the CO2 avoided cost, the impact of six alternative steam supply scenarios are considered. The evaluations show that the CO2 avoided cost can decrease by up to 35% depending on the steam supply and electricity price. However the possibility of these steam supply alternatives are specific to the considered cement plant, emphasizing therefore that CO2 avoided cost from cement shall rather be given as a range depending on the steam supply than as a unique value as often illustrated in the literature.