gebhart/patrepeval huggingface dataset:
Use of Hybridoma Monoclonal Antibodies in the Detection of Antigenic Differences Between Rabies and Rabies-related Virus Proteins. I. The Nucleocapsid Protein (1980)

Twenty-one hybridoma cultures, obtained through the fusion of mouse myeloma cells with splenocytes of BALB/c mice immunized with either rabies virus or Mokola virus, secreted monoclonal antibodies specific for the nucleocapsid of the inducer virus. They displayed different specificities for the nucleocapsids of rabies and rabies-related viruses and could be classified into eight groups which are likely to correspond to different antigenic determinants on the nucleocapsid. Four strains of fixed rabies virus (CVS, ERA, Flury-LEP and Kelev) could not be differentiated by the nucleocapsid-specific hybridoma antibody. The Flury-HEP virus (derived from Flury-LEP) as well as the rabies-related viruses Mokola, Lagos bat and Duvenhage, showed marked differences in their reactivities with hybridoma antibodies to nucleocapsid. A selected panel of three of these hybridomas may be used for a rapid differential diagnosis among all members of the Lyssavirus group.
High resolution NMR studies of histidine-substituted and histidine-perturbed hemoglobin variants. Histidine assignments, electrostatic interactions at the protein surface, and implications for hemoglobin S polymerization. (1986)

The aromatic region of the proton NMR spectrum of human adult hemoglobin (HbA) contains resonances from at least 11 titratable histidine residues. Assignments for five beta chain histidines have previously been proposed. In order to further characterize the aromatic spectra of HbA we studied 11 histidine-substituted and -perturbed hemoglobin variants in oxy and deoxy states and at different pH values by 400 MHz NMR spectroscopy. We propose assignments for the resonances corresponding to the C2 protons of His alpha 20, His alpha 72, His alpha 112, and His beta 77 in oxy and deoxy spectra and of His beta 97 and His beta 117 in deoxy spectra. Our assignments for His beta 2 and His beta 117 in the oxy state agree with those previously reported for the CO form, but in the deoxy state our spectra suggest a different assignment. Studies with Hb variants in which a histidine is perturbed by a neighboring substitution suggest additional assignments for His alpha 50 and His alpha 89 and demonstrate a strong dependence of the imidazole ring pK on hydrogen bond interactions and on the net charge of neighboring residues. Some of the newly proposed assignments of histidine resonances are used to discuss specific intermolecular interactions implicating His alpha 20, His beta 77, and His beta 117 in deoxy HbS polymers.
Design Guidelines for Technology-Mediated Social Interaction in a Presence Sensing Physical Space (2018)

Technology for building smart homes is here today; however, a solid understanding of how people will interact in these spaces is not. In this paper, we present our research into designing a smart living space that focuses on inherent social behavior and in turn facilitates social interactions. We start by explaining our initial design scenario, and then discuss the process whereby we obtained data about user needs in a smart living space. We then offer six principles for building an environment that assists in home activities and explain how these principles could be applied to similar projects. We walk through selected parts of our design and then offer recommendations and future directions for smart living space research.
Phase II study of weekly administration of docetaxel (D) in combination with the epidermal growth factor receptor (EGFR) inhibitor erlotinib (E) in metastatic breast cancer (MBC). (2009)

Abstract Abstract #3124 Background: Single agent weekly docetaxel (D) is an active agent in the treatment of metastatic breast cancer (MBC) with response rates of 29% - 53%. Erlotinib (OSI-774, Tarceva®) is a tyrosine kinase inhibitor directed against EGFR, which is overexpressed in 30-40% of breast cancers, making EGFR an attractive treatment target. This study was designed to assess the combination of D and E in previously untreated recurrent and/or MBC.&#x2028; Methods: Adult patients with histologically confirmed MBC without prior chemotherapy for recurrence or metastases were eligible. Treatment plan was: D (initially 35 mg/m2 intravenous infusion weekly x 3 every 4 weeks) and E 150 mg orally daily uninterrupted. In patients with responding or stable disease, E was continued in 4 week cycles following a minimum of 6 cycles of D and E. Estimates of overall survival (OS) and progression free survival (PFS) were made by Kaplan-Meier method and the difference between groups by log-rank test. Tumor EGFR expression by immunohistochemisty and ER/PR was correlated with OS and PFS.&#x2028; Results: 39 female pts were enrolled between 12/02 and 8/06. The median age was 51 yrs (range 28-78). The median number of cycles of D and E received was 4 (range 1-26) and of E following D and E was 11 (range 2-18). EGFR, ER/PR and Her-2/neu status was determined on 35/39 patients. EGFR: 23 positive, 12 negative. ER/PR: 25 positive, 10 negative. Her-2/neu: 2 positive, 33 negative. Ten pts. were not evaluable for survival or response due to toxicity occurring within the first cycle. Best responses (n=29) ; PR 11(39%), SD 4 (14%), PD 13 (45%), and clinical benefit (PR+SD) 15 (54%). Median PFS was 8 mos (95% CI: 4.4-12.2). PFS for EGFR negative tumors appeared better than EGFR positive tumors (12 mos PFS 33% vs. 23%) but was not significant (p = 0.53). There was no difference in OS between these groups (p=0.38). PFS and OS for ER/PR positive pts was significantly higher than ER/PR negative pts 6 mos PFS 67% vs. 25% (p= 0.009) and 2 yr OS 53.9% vs. 12.5% (p=0.015). , All patients were included for toxicity assessment (n-39). The first 26 pts received planned D dose of 35mg/m2. Because of non-hematologic toxicity, trial was subsequently modified to start D at 25 mg/m2. Grade 3 or 4 Leukopenia was seen in 15% pts. Principal non-hematologic grade 3-4 toxicities included anorexia, diarrhea, and fatigue (18% pts).&#x2028; Conclusions: Combination therapy for advanced breast cancer with docetaxel and erlotinib shows promising activity with favorable response compared with other studies. There was no significant association with EGFR expression and PFS, however this combination is more favorable for ER positive patients. Randomized trials for ER positive disease is warranted to further investigate the efficacy of this combination compared to single agent docetaxel. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3124.
Observation of large second order susceptibility via intersubband transitions at λ∼10 μm in asymmetric coupled AlInAs/GaInAs quantum wells (1991)

We report the first observation of second harmonic generation associated with intersubband transitions in AlInAs/GaInAs quantum wells. The measured second order susceptibility in our new asymmetric coupled well structure lattice matched to InP is 4.8×10−8 m/V, about 100 times larger than bulk values in InP, GaAs, and InAs.
Prophylactic COX 2 Inhibitor: An End to the Yom Kippur Headache (2006)

Rofecoxib 50 mg taken prior to a 25-hour ritual fast prevents and attenuates fasting headache.
Kinetic theory of ion ring compression (1979)

A general kinetic theory is developed for the adiabatic compression of ion rings, and associated plasma, in an external magnetic mirror field Be(t). The single particle distribution function is shown to be given by f (ℋ,𝒫ϑ,t) =F (I,𝒫ϑ) during axisymmetric compression in the absence of instabilities and under conditions where the particle motion is ergodic in the poloidal (r,z) plane. Here, ℋ and 𝒫ϑ are the energy and canonical momentum of a ring ion; I (ℋ,𝒫ϑ) is an adiabatic invariant involving an average over the region of the poloidal plane accessible to a particle with constants ℋ and 𝒫ϑ; and F is an invariant function. A complete description of ring compression is obtained from F, which gives the ring current density Jbϑ, from an appropriate constitutive relation for the plasma response, which gives the plasma current density Jpϑ, and from Ampère’s law. The theory is valid for rings of arbitrary aspect ratio, the particle orbits are essentially unrestricted, and account is taken of ring particle evaporation. A general analysis is made of energy and angular momentum conservation during compression. In particular, the total power input and the power absorbed are derived in terms of the magnetic moment of the ring-plasma system, M (Be).
Mechanisms for the autoxidation of polyunsaturated lipids (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanisms for the autoxidation of polyunsaturated lipidsNed A. PorterCite this: Acc. Chem. Res. 1986, 19, 9, 262–268Publication Date (Print):September 1, 1986Publication History Published online1 May 2002Published inissue 1 September 1986https://doi.org/10.1021/ar00129a001RIGHTS & PERMISSIONSArticle Views1710Altmetric-Citations320LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (794 KB) Get e-Alerts Get e-Alerts
Learning-based approach for online lane change intention prediction (2013)

Predicting driver behavior is a key component for Advanced Driver Assistance Systems (ADAS). In this paper, a novel approach based on Support Vector Machine and Bayesian filtering is proposed for online lane change intention prediction. The approach uses the multiclass probabilistic outputs of the Support Vector Machine as an input to the Bayesian filter, and the output of the Bayesian filter is used for the final prediction of lane changes. A lane tracker integrated in a passenger vehicle is used for real-world data collection for the purpose of training and testing. Data from different drivers on different highways were used to evaluate the robustness of the approach. The results demonstrate that the proposed approach is able to predict driver intention to change lanes on average 1.3 seconds in advance, with a maximum prediction horizon of 3.29 seconds.
Synthesis of (all‐<i>E</i>,2<i>R</i>,2′<i>R</i>)‐oscillol (1996)

Abstract Optically active (all‐ E ,2 R ,2′ R )‐oscillol (= (all‐ E ,2 R ,2′ R )‐3,4,3′,4′‐tetradehydro‐1,2,1′,2′‐tetrahydro‐ψ,ψ‐carotene‐1,2,1′,2′‐tetrol; 1 ) was synthesized according to the C 10 + C 20 + C 10 = C 40 strategy, applying the Wittig reaction to couple the synthons 4 and 6 . The chiral centre was introduced by a Sharpless dihydroxylation of 3‐methylbut‐2‐enyl 4‐nitrobenzoate ( 8 ).
Physical and circuit modeling of HfO<inf>2</inf> based ferroelectric memories and devices (2017)

The discovery of ferroelectric properties in polycrystalline HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> has revived the interest in ferroelectric (FE) memories, which shows scaling feasibility allowing targeting high-density storage applications. In order to provide engineering guidelines for FE memory devices it is crucial to establish a correlation between the electrical device performances and the underlying physical mechanisms. In this work, we will discuss physical and circuit modeling approaches for FE memories connecting the FE HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> materials properties to the electrical performances of memory cells, artificial synapse for neuromorphic and in memory computing applications.
Microporous membranes obtained from polypropylene blends with superior permeability properties (2007)

Abstract A blend of two polypropylene resins, different in molecular structure, one with linear chains and the other with long chain branches, was investigated to develop microporous membranes through melt extrusion (cast film process) followed by film stretching. The branched component significantly affected the row‐nucleated lamellar crystalline structure in the precursor films. The arrangement and orientation of the crystalline and amorphous phases were examined by wide angle X‐ray diffraction and Fourier transform infrared spectroscopy methods. It was found that blending of a small amount of a long chain branched polypropylene improved the orientation of the both crystalline and amorphous phases in the precursor films. Annealing, followed by cold and hot stretching were consequently employed to generate and enlarge pores in the films as a result of lamellae separation. SEM micrographs of the surface of the membranes obtained from the blend revealed elongated thin fibrils and a large number of lamellae. The lamellae thickness for the blend was much shorter in comparison to that of the linear PP precursor film. The permeability of the samples to water vapor and N 2 was significantly enhanced (more than twice) for the blend system. The porosity of the blend membrane showed a significant improvement with a value of 53% compared to 41% for the linear PP membrane. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 46: 148–157, 2008
Introduction (2012)

The introduction, “Caring about Things,” makes a case for why archaeology should be understood as the “discipline of things.” It sets out a definition of things, sketches the rudiments of a symmetrical archaeology, and lays out the structure of the -book.
The Application of an Enamel Matrix Protein Derivative (Emdogain®) in Regenerative Periodontal Therapy: A Review (2007)

Regenerative periodontal therapy aims at reconstitution of the lost periodontal structures such as new formation of root cementum, periodontal ligament and alveolar bone. Findings from basic research indicate that enamel matrix protein derivative (EMD) has a key role in periodontal wound healing. Histological results from animal and human studies have shown that treatment with EMD promotes periodontal regeneration. Moreover, clinical studies have indicated that treatment with EMD positively influences periodontal wound healing in humans. This review aims to present an overview of evidence-based clinical indications for regenerative therapy with EMD.
Alcohol partition in a water-in-oil microemulsion from small-angle neutron scattering (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlcohol partition in a water-in-oil microemulsion from small-angle neutron scatteringE. Caponetti, A. Lizzio, R. Triolo, W. L. Griffith, and J. S. Johnson Jr.Cite this: Langmuir 1992, 8, 6, 1554–1562Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/la00042a011https://doi.org/10.1021/la00042a011research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
"Architextured" fluid management of biological liquids. (1987)

Novel "architextured" liquid-spreading and capillary flow systems are described as an adjunct to diagnostic procedures that range from the fully automated to techniques requiring no instrumentation. These systems were developed because of the observation that local features of macroscopic surfaces--roughness and chemical heterogeneity--influence both the spreading rate and equilibrium shape of liquid drops on solid surfaces. By use of organized patterns of surface structure complemented by surface chemical modification, this uncontrolled and undirected capillary flow is recast into flow behavior that is remarkably reproducible. Flow fronts are engineered to have prescribed shapes, and flow rates that are insensitive to the rheological properties of the biological liquids are obtained. To demonstrate the utility of fluid-management principles, we describe the implementation of architextured capillary configurations in microvolume liquid dispensers and potentiometric analytical systems.
Efficient generation of functional pancreatic β‐cells from human induced pluripotent stem cells (2016)

Functional pancreatic β-cells were generated from human iPSCs. Induction of definitive endoderm and spheroid formation may be key steps for producing these cells.
Carbon metabolism of the moderately acid-tolerant acetogen<i>Clostridium drakei</i>isolated from peat (2008)

A moderately acid-tolerant, malodorous bacterium, strain FP, was isolated from peat that had a pore water pH of c. 4.2. The 16S rRNA gene sequence of FP was closely related to that of acetogens Clostridium drakei, Clostridium scatologenes, and Clostridium carboxidivorans. The DNA-DNA reassociation values obtained with DNA from FP and that of these three acetogens approximated 80%, 64%, and 59%, respectively, indicating that FP was a new strain of C. drakei. FP had broad pH and temperature ranges (3.6-7.4 and 5-40 degrees C, respectively), and metabolized a wide range of substrates, including cellobiose, glucose, xylose, vanillate, ferulate, lactate, propanol, formate, H(2)-CO(2), and CO-CO(2). Acetate was the primary reduced end product, and substrate/product stoichiometries were indicative of acetogenesis at circumneutral pH. Butyrate and H(2) became significant products from glucose at low pH. FP tolerated and could consume moderate amounts of O(2). These results (1) demonstrate that peat can harbor acetogens with a broad substrate range and tolerance to transient exposure to O(2), and (2) confirm that C. drakei, the type strain of which was originally isolated from an acidic coal mine pond, occurs in moderately acidic habitats.
Application of linear pH gradients for the modeling of ion exchange chromatography: Separation of monoclonal antibody monomer from aggregates (2015)

The mobile phase pH is a key parameter of every ion exchange chromatography process. However, mechanistic insights into the pH influence on the ion exchange chromatography equilibrium are rare. This work describes a mechanistic model capturing salt and pH influence in ion exchange chromatography. The pH dependence of the characteristic protein charge and the equilibrium constant is introduced to the steric mass action model based on a protein net charge model considering the number of amino acids interacting with the stationary phase. This allows the description of the adsorption equilibrium of the chromatographed proteins as a function of pH. The model parameters were determined for a monoclonal antibody monomer, dimer, and a higher aggregated species based on a manageable set of pH gradient experiments. Without further modification of the model parameters the transfer to salt gradient elution at fixed pH is demonstrated. A lumped rate model was used to predict the separation of the monoclonal antibody monomer/aggregate mixture in pH gradient elution and for a pH step elution procedure-also at increased protein loadings up to 48 g/L packed resin. The presented model combines both salt and pH influence and may be useful for the development and deeper understanding of an ion exchange chromatography separation.
Metal Forming : Fundamentals and Applications (1983)

Briefly reviews the basic principles of metal forming but major emphasis is on the latest developments in the design of metal-forming operations and tooling. Discusses the position of metal forming in manufacturing and considers a metal-forming process as a system consisting of several interacting variables. Includes an overall review and classification of all metal-forming processes. The fundamentals of plastic deformation - metal flow, flow stress of metals and yield criteria - are discussed, as are significant practical variables of metal- forming processes such as friction, temperatures and forming machines and their characteristics. Examines approximate methods of analyzing simple forming operations, then looks at massive forming processes such as closed-die forging, hot extrusion, cold forging/ extrusion, rolling and drawing (discussion includes the prediction of stresses and load in each process and applications of computer-aided techniques). Recent developments in metal-forming technology, including CAD/CAM for die design and manufacture, are discussed, and a review of the latest trends in metal flow analysis and simulations.
Protocol compatibility tester for CDMA mobile system (CMS) (2002)

This paper present the architecture of the protocol analyzer, simulator, and tester (PAST) which can be used for the protocol compatibility test of the CDMA mobile system (CMS). The PAST is also applicable to the protocol compatibility test for a general communication system. The PAST has some special features such as a multiprocessing kernel, multi-scenario handling to simulate more than one system simultaneously. These features are very useful for testing category soft-handoff, multi-party call, etc., in the CMS.
Obstacle Geometry Effect on the Stability of Two-Dimensional Incompressible Flow in a Channel (2016)

Two-dimensional incompressible fluid flow around a rectangular shape placed over a larger rectangular shape is analyzed numerically. The vortex shedding is investigated at different arrangements of the two shapes. The calculations are carried out for several values of Reynolds numbers from low values up to 52. At low Reynolds number, the flow remains steady. The flow characteristics are analyzed for each configuration. The analysis of the flow evolution shows that with increasing Re beyond a certain critical value, the flow becomes unstable and undergoes a bifurcation. It is observed that the transition to unsteady regime is performed by a Hopf bifurcation. The critical Reynolds number beyond which the flow becomes unsteady is determined for each configuration.