gebhart/patrepeval huggingface dataset:
<sup>13</sup>C Dynamic Nuclear Polarization:  an Alternative Detector for Recycled-Flow NMR Experiments (1998)

Static NMR experiments on insensitive nuclei (e.g., (13)C) have been generally difficult because of low magnetogyric ratios and/or poor natural abundance, even at the highest magnetic fields available. One method of overcoming these sensitivity limitations is dynamic nuclear polarization (DNP), which can be utilized to enhance NMR signals relative to those obtained with static NMR detection. In this study, we report a recycled-flow DNP apparatus capable of monitoring (13)C scalar-dominated enhancements 1-2 orders of magnitude greater than those obtainable using the conventional recycled-flow (13)C NMR experiment. Specifically, a mixture of benzene and several chlorocarbons were continuously "recycled" through a (13)C DNP spectrometer. Results indicate successful detection with the (13)C DNP approach in scalar-dominated cases, where analytes could not be observed with conventional static or flow NMR detection in a reasonable length of time.
Intelligent Chinese Input Method Based on Android (2011)

This paper introduces the basic principles of sentence level Chinese phonetic input method,and discusses the difficulties and solutions of achieving it on mobile device.It achieves a input method on Android OS.By now,it runs well on Dopod's mobile phone A3288 with high efficiency.The conversion accuracy is 86.92%,and with the training of input method,the accuracy can raise quickly.
The alkaline peroxide oxidation of 1′,2′-dihydroxy-3,4-benzotropolones (1969)

The alkaline peroxide oxidation of 1′,2′-dihydroxy-3,4-benzotropolones proceeds via the corresponding 1′,2′-quinone anions, which undergo two types of peroxide decomposition. (a) At low temperature and alkali concentration, peroxide attack on the 3′- and 4′-positions of the cyclohexadiene ring predominates, and results in the formation of unstable hydroperoxides which decompose to hydroxyquinones, also formed directly by solvolysis. The greater reactivity of the 3′-position is ascribed to its conjugation with both quinonoid and tropolone carbonyl groups. The 2′-hydroxy-1′,4′-quinones formed from 3′-substituted substrates are further oxidised to tropolone-3,4-dicarboxylic anhydride. (b) At high temperature and alkali concentration, muconic acids are formed via tetrahydroxybenzotropolones and dihydroxy-2′,6′-quinones arising from peroxide attack on the 5- and 6- and 7-positions of the tropolone ring. These tetrahydroxybenzotroplones (also obtained by hydrolysis of the abnormal Thiele penta-acetates of the 1′,2′-quinones) are not formed when the substrate bears a carboxy-group at the 6-position; in this case peroxide attack on the 1′- and 2′-positions of the cyclohexadiene ring predominates.These results are discussed in terms of steric and charge effects, and mechanisms for each type of reaction path are suggested.
Adéu, Rocambole. In memoriam Roger Bellet (1999)

jubilat, felic i ple de vida.
Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through Application of an “Agreement Docking” Method (2005)

Structurally related glucocorticoid receptor (GR) binders were docked into the GR active site to select the binding mode closest to the true docking mode. This process, termed an "agreement docking method", led to the design of tetrahydronaphthalene 9. The method was validated by the syntheses of 9 and related analogues, which are potent binders of GR. 15a is a partial agonist while 9e and 15a are micromolar antagonists in a mouse mammary tumor virus transactivation assay.
Minimizing temperature sensitivity of optical fibers (1981)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text N. Lagakos and J. A. Bucaro, "Minimizing temperature sensitivity of optical fibers," Appl. Opt. 20, 3276-3278 (1981) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Augmentation of Macular Pigment Following Supplementation with All Three Macular Carotenoids: An Exploratory Study (2010)

We report significant increases in serum concentrations of MZ and L following supplementation with MZ, L, and Z and a significant increase in MPOD, including its spatial profile, after two weeks of supplementation. Also, this study has detected the possible presence of MZ in human serum pre-supplementation and the ability of the study carotenoid formulation to rebuild central MPOD in subjects who have atypical profiles at baseline.
Normally-Off 4H-SiC Power MOSFET with Submicron Gate (2008)

In order for SiC-MOSFET to be practical in various power electronics applications, low specific on-resistance Ron,sp, high breakdown voltage and “normally-off” characteristics have to be fulfilled even at high temperature. We fabricated a SiC-MOSFET employing a submicron gate with channel length Lg of 0.5μm by a self-aligned implantation and aδ-doped epitaxial channel layer to successfully demonstrate the following features. The normally-off characteristics was confirmed from room temperature to 200°C where the therethold voltages Vth were 2.9V at room temperature and 1.6V at 200°C, respectively. The Ron,sp were 4.6mΩcm2 at room temperature and 9.2mΩcm2 at 200°C, respectively, while the breakdown voltage was greater than 1400V .
Evaluating Sodium Salts as Pushing Agents on High‐Performance Anion‐Exchange Chromatography with Pulsed Amperometric Detection for Maltodextrin Analysis (1997)

Abstract Sodium hydroxide and sodium salts of acetate, nitrate and sulfate were chosen as pushing agents for maltodextrin analysis by high‐performance anion‐exchange chromatography with pulsed amperometric detection (HPAEC‐PAD). Different concentrations of sodium hydroxide solution, 100 mM to 500 mM, were used for direct detection of maltodextrins on a set of gold working and saturated calomel reference electrodes. Chromatographic capacity factors, k′, of maltodextrins increased as molecular size increased. Sodium hydroxide alone was not adequate for an optimal maltodextrin separation. Sodium salts of acetate, nitrate, and sulfate were tested as pushing agents. The salts were compatible with the system, increased the separation selectivity and enhanced the detector response of PAD. The ability of pushing agents to decrease k′ followed the order of sulfate > nitrate > acetate > hydroxide. After being eluted with pushing agents, the column regeneration time of CarboPac PA1 was 180, 240 and 360 min for the acetate, nitrate, and sulfate salts, respectively. An alternate process to shorten the regeneration time for maltodextrin separation was demonstrated. Sodium azide, as a preservative, did not affect the separation and quantification of the analysis. Sodium nitrate was the best pushing agent for the homologous maltodextrin separation.
Is the Future of the Microfinance Movement to be Found on the Internet (2007)

This paper will give a brief description of the microfinance movement and the growing current interest in microfinance/microcredit as a weapon in the fight against global poverty. Then two trends, the development of new sources of capital for the microfinance movement and the advent of social lending on the Internet will be outlined. Finally, the manner in which the intersection of these two trends might impact microfinance/microcredit is considered. This paper was presented at the 17th International Conference of the International Trade and Finance Association, Miami, Florida, May 16-20, 2007.
Viability of Ascaris suum, Ascaris lumbricoides and Trichuris muris eggs to alkaline pH and different temperatures. (1995)

Disposal of wastewater sludges in agricultural soil is a way to recover mineral and organic substances. Nevertheless disposing and handling such untreated, potentially contaminated sludges may be hazardous for human health and the environment. The aim of this study is to evaluate a method for sludge decontamination consisting in alkaline treatment with ammonia at different temperatures (22 degrees C, 30 degrees C, 40 degrees C) to establish its effects on the survival of Ascaris suum, Ascaris lumbricoides and Trichuris muris eggs. Our experiments show that the combination of alkalinization with NH4OH at a temperature of 30 degrees C causes the eggs to be inactivated. A 40 degrees C temperature was unfavourable to the development of these helminths in the eggs, with or without addition of NH4OH. At 22 degrees C ammonia did not have any effect on their viability. Ammonia at suitable temperatures therefore, is able to destroy Ascaris and Trichuris eggs. It is suggested that this technology be adopted to decontaminate wastewater sludge before using it as manure in agriculture.
Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction (2016)

Prostate cancer is the most common type of cancer diagnosed and the second leading cause of cancer-related death in American men. Natural Killer (NK) cells are the first line of defense against cancer and infections. NK cell function is regulated by a delicate balance between signals received through activating and inhibitory receptors. Previously, we identified Lectin-like transcript-1 (LLT1/OCIL/CLEC2D) as a counter-receptor for the NK cell inhibitory receptor NKRP1A (CD161). Interaction of LLT1 expressed on target cells with NKRP1A inhibits NK cell activation. In this study, we have found that LLT1 was overexpressed on prostate cancer cell lines (DU145, LNCaP, 22Rv1 and PC3) and in primary prostate cancer tissues both at the mRNA and protein level. We further showed that LLT1 is retained intracellularly in normal prostate cells with minimal cell surface expression. Blocking LLT1 interaction with NKRP1A by anti-LLT1 mAb on prostate cancer cells increased the NK-mediated cytotoxicity of prostate cancer cells. The results indicate that prostate cancer cells may evade immune attack by NK cells by expressing LLT1 to inhibit NK cell-mediated cytolytic activity through LLT1-NKRP1A interaction. Blocking LLT1-NKRP1A interaction will make prostate cancer cells susceptible to killing by NK cells and therefore may be a new therapeutic option for treatment of prostate cancer.
Practical Operation of a Small Motion Picture Studio (1951)

The problems and methods of handling television film commercial and short productions economically and in a limited space are outlined.
Influence of trench etching on super junction devices fabricated by trench filling (2004)

We have proposed a fabrication method for super junction (SJ) diodes with low leakage current characteristics by using a wet anisotropic trench etching and Si(111) oriented trench epitaxial filling processes. The SJ diodes show electrical characteristics with a breakdown voltage of 225 V and a leakage current density below 1/spl times/10/sup -7/ A/cm/sup 2/. By experimental comparisons between three types of SJ diodes of the [111] oriented trench, formed by wet anisotropic etching, and [111] and [010] oriented trenches formed by the conventional reactive ion etching (RIE) process, we have clarified an effect of the wet etching process on the lower leakage characteristics of the trench filling SJ diode.
Prospects for Farming the Open Ocean (1979)

Presently, visualized prospects for farming the open oceans of the earth are based mainly on results obtained by the Navy’s Ocean Food and Energy Farm Project. This Project was sponsored by several Federal agencies and private industry, and its results indicated that a system of giant oceanic farms would be capable of producing foods, liquid and gaseous fuels, lubricants, fertilizers, industrial chemicals, and plastics at rates sufficient to supply all the related requirements of one average U.S. citizen for each 2 to 3 acres of cultivated ocean (one acre = 0.4047 hectare = 4047 sq m). Synthetic natural gas from the system was projected to cost from about $2 up to about $7 per million Btu, depending mainly on credit values assumed for foods and other products (all dollar values expressed in constant 1974 dollars; 1 Btu = one British thermal unit = 252 calories = 1/3413th kwh). Although Navy participation in the Project has now been terminated, the Project is proceeding under management of the General Electric Co. with financial sponsorship being furnished by the American Gas Industry and the U.S. Department of Energy.
Proton pump inhibitor use and risk of community-acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapy (2006)

Proton pump inhibitor use was associated with an increased risk of community-acquired CDAD, when cases were defined by receipt of prescription for oral vancomycin therapy. Prior antibiotic exposure was also a significant risk factor, but a significant proportion of the patients with community-acquired CDAD had no such exposure.
COMBINING HIERARCHICAL FILTERING, FUZZY LOGIC, AND SIMULATION WITH SOFTWARE AGENTS FOR IP (INTELLECTUAL PROPERTY) SELECTION IN ELECTRONIC DESIGN (2001)

SAFIPS (Software Agents for IP Selection) environment is designed to improve quality and speed of finding IPs on Internet for SoC (System-on-Chip) projects. The software agents take responsibility for establishing communication with multiple suppliers of IPs and automatically retrieve information from their databases using metalanguage (XML), and data specifications compliant with ECIX (Electronic Component Information eXchange) specifications. The communication environment is based on Dictionaries for terminology and list of parameters, and on Registry for the list and web addresses of suppliers. The information obtained by software agents is analyzed by a system of fuzzy logic rules compiled in the process of a dialog between the customer and SA. The software agent asks the customer questions and provides templates for answers. The answers are automatically converted into the membership functions and fuzzy logic rules that are applied to evaluation of potential candidate IPs. As soon as replies to the query by SA start to come, data are analyzed by software agents and IPs can be excluded from further consideration if there is drastic mismatch between expected values and IP parameters and constraints. The remaining IPs are evaluated by the hierarchical system of rules and ranks are assigned to those which passed the preliminary tests. The top candidates are subjected to simulation together with the behavioral models provided by customers under supervision of software agent. The timing diagrams obtained from simulation are going to be analyzed to evaluate their equivalence. Only after that the system presents the candidate IPs for the final selection. The main goal to save valuable design time can be achieved by such system. The text is accompanied by an example.
Merging focused ion beam patterning and optical lithography in device and circuit fabrication (1990)

Combining optical lithography and focused ion beam (FIB) patterning in direct-write device and circuit fabrication by generating large features optically and small features with the FIB can significantly reduce beam writing time. Our approach to FIB pattern definition is ideally suited for alignment to optically patterned features and takes full advantage of the lithographic and implantation capabilities of the FIB. Optical and FIB patterns are designed simultaneously in the very large scale integrated layout tool magic, [magic, Report No. UCB/CSD 85/225 University of California, Berkley (March 1985)]. We have developed a software package magtofib [James E. Murguia, Christian Musil, Mark Shepard, Sasan Zamani, magtofib, Massachusetts Institute of Technology (1989)] which takes its input from the magic data file and converts it to FIB stage and beam commands. The FIB is aligned by operating in scanning ion microscope mode and finding the centroid of an optically produced die alignment mark. Since the coordinate systems of a typical optical reticle, stepper, and of the FIB are, in general, nonorthogonal and rotated with respect to the wafer, the alignment error increases as one moves away from the alignment point. To place features 1 cm apart to an accuracy of 0.1 μm, calibration must be better than one part in 105. This precision is achieved with a linear transformation calculated from three alignment crosses on the pattern perimeter which transform computer aided design layout coordinates into wafer coordinates. The transformation is calculated once per wafer. The patterning tools have been demonstrated using three types of alignment marks and two resists, on a variety of devices, as well as x-ray masks. The alignment accuracy is ±0.1 μm. In addition, we report a process to combine optical and FIB lithography on the same layer using the same positive UV resist (KTI 820) as a negative FIB resist.
Speed profile optimization for train operation based on ant colony algorithm (2015)

Automatic train operation (ATO) system generally consists of the generation of recommended speed profile and the speed tracking strategy. It determines the tracked trajectory and the energy consumption of trains during the trip. Therefore, the optimization of recommended speed profile and the tracking strategy are regarded as two important means to achieve energy-efficient train operation between the successive stations. With considering the ATO tracking strategy, an optimization method of the recommended speed profile is proposed in this paper. Base on the approximate calculation, a discrete combination optimization model is formulated and a new MAX-MIN ant system (MMAS) is taken as the core algorithm. With the fixed speed tracking strategy, this method achieves the recommended speed profile with optimized energy consumption and a perfect running punctuality along the actual tracked trajectory. The switching times of operation during the cruising phase is reduced by integrating the drivers' experience, which also reduces the energy consumption of train running between stations. The case results based on Beijing Yizhuang Metro Line in China verify the effectiveness of the proposed method, which has a good performance on energy-efficient train operation.
Increased proportion of docosahexanoic acid and high lipid peroxidation capacity in erythrocytes of stroke patients. (1994)

The results suggest that the erythrocytes of ischemic stroke patients with very high lipid peroxidation capacity displaying an abnormal fatty acid composition are much more vulnerable to lipid peroxidation. The increased proportion of docosahexanoic acid and the high lipid peroxidation capacity of erythrocytes play a pathogenetic role and explain the hemorheological disturbances observed in the microcirculation of stroke patients.
Biology of SNU Cell Lines (2005)

SNU (Seoul National University) cell lines have been established from Korean cancer patients since 1982. Of these 109 cell lines have been characterized and reported, i.e., 17 colorectal carcinoma, 12 hepatocellular carcinoma, 11 gastric carcinoma, 12 uterine cervical carcinoma, 17 B-lymphoblastoid cell lines derived from cancer patients, 5 ovarian carcinoma, 3 malignant mixed Mllerian tumor, 6 laryngeal squamous cell carcinoma, 7 renal cell carcinoma, 9 brain tumor, 6 biliary tract, and 4 pancreatic carcinoma cell lines. These SNU cell lines have been distributed to biomedical researchers domestic and worldwide through the KCLB (Korean Cell Line Bank), and have proven to be of value in various scientific research fields. The characteristics of these cell lines have been reported in over 180 international journals by our laboratory and by many other researchers from 1987. In this paper, the cellular and molecular characteristics of SNU human cancer cell lines are summarized according to their genetic and epigenetic alterations and functional analysis.
Source address validation based Ethernet switches for IPv6 network (2012)

Traditional Internet architecture doesn't check the source address when forwarding the packet, and that led to various source address spoofing forgery attacks. This paper proposes a novel scheme of source address validation based Ethernet switches for IPv6 Network. This system validate the source address in the various network address allocation mode, including manual address configuration, stateless address auto configuration, Dynamic Host Configuration Protocol and their mix address configuration mode. The demonstration implementation of the system is presented in this paper.
Nanosampling internal reflection FT‐IR study of polymer filaments (1987)

This paper reports on the development of a new accessory which allows the infrared spectrum to be recorded by internal reflectance spectroscopy from nanogram and microgram samples. Specifically, spectra taken of the end of a 20-pm polyester filament, a 250-pm multicomponent acrylic fiber, and a 5-ng droplet of paraffin oil will be presented. Since the smallest filament is 20 pm, the calculated sample size is within the nanogram range.
Early Deficits in Cortical Control of Swallowing in Alzheimer's Disease (2010)

The goal of this study was to determine whether functional changes in cortical control of swallowing are evident in early Alzheimer's disease (AD), before dysphagia (swallowing impairment) is evident. Cortical function was compared between an early AD group and a group of age-matched controls during swallowing. Swallowing oropharyngeal biomechanics examined from videofluoroscopic recordings were also obtained to more comprehensively characterize changes in swallowing associated with early AD. Our neuroimaging results show that the AD group had significantly lower Blood-Oxygen-Level-Dependent (BOLD) response in many cortical areas that are traditionally involved in normal swallowing (i.e., pre and postcentral gyri, Rolandic and frontal opercula). There were no regions where the AD group showed more brain activity than the healthy controls during swallowing, and only 13% of all active voxels were unique to the AD group, even at this early stage. This suggests that the AD group is not recruiting new regions, nor are they compensating within regions that are active during swallowing. In videofluoroscopic measures, the AD group had significantly reduced hyo-laryngeal elevation than the controls. Although, swallowing impairment is usually noted in the late stages of AD, changes in cortical control of swallowing may begin long before dysphagia becomes apparent.
A systolic power-of-two multiplier structure (2003)

A power-of-two multiplier with a fully pipelined structure is presented. The design is based on dividing the multiplication into three succeeding stages so that no bit accumulation occurs in any of them. The only nontrivial part of this multiplier is the implementation of the second stage, which requires a fully pipelined shifter. A design example of the shifter is presented to demonstrate the mechanism of the shifter when the input data path is 2 b. Generalizing this technique to a multiplier with an input data path of an arbitrary number of bits simply involves properly extending the size of the circuit and changing the controlled parameters and clocking schemes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance (2013)

Eukaryotes employ elaborate mitochondrial quality control (MQC) to maintain the function of the power-generating organelle. Parkinson's disease-associated PINK1 and Parkin actively participate in MQC. However, the signaling events involved are largely unknown. Here we show that mechanistic target of rapamycin 2 (mTORC2) and Tricornered (Trc) kinases act downstream from PINK1 to regulate MQC. Trc is phosphorylated in mTORC2-dependent and mTORC2-independent manners and is specifically localized to mitochondria in response to PINK1, which regulates mTORC2 through mitochondrial complex-I activity. Genetically, mTORC2 and Trc act upstream of Parkin. Thus, multiplex kinase signaling is acting between PINK1 and Parkin to regulate MQC, a process highly conserved in mammals.