gebhart/patrepeval huggingface dataset:
The importance of the individual (1980)

article The importance of the individual Share on Author: Robert L. Glass Boeing Aerospace Co. Boeing Aerospace Co.View Profile Authors Info & Claims ACM SIGSOFT Software Engineering NotesVolume 5Issue 3July 1980 pp 48–50https://doi.org/10.1145/1005913.1005915Online:01 July 1980Publication History 3citation36DownloadsMetricsTotal Citations3Total Downloads36Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Automatic Performance Diagnosis and Tuning in Oracle (2005)

Performance tuning in modern database systems requires a lot of expertise, is very time consuming and often misdirected. Tuning attempts often lack a methodology that has a holistic view of the database. The absence of historical diagnostic information to investigate performance issues at first occurrence exacerbates the whole tuning process often requiring that problems be reproduced before they can be correctly diagnosed. In this paper we describe how Oracle overcomes these challenges and provides a way to perform automatic performance diagnosis and tuning. We define a new measure called ‘Database Time’ that provides a common currency to gauge the performance impact of any resource or activity in the database. We explain how the Automatic Database Diagnostic Monitor (ADDM) automatically diagnoses the bottlenecks affecting the total database throughput and provides actionable recommendations to alleviate them. We also describe the types of performance measurements that are required to perform an ADDM analysis. Finally we show how ADDM plays a central role within Oracle 10g’s manageability framework to self-manage a database and provide a comprehensive tuning solution.
Nonperturbing Fluorescent Labeling of Polysaccharides (2002)

A fluorescent labeling procedure, which does not perturb macromolecular conformations, was employed to bind a rhodamine derivative to the reducing end of several water-soluble polysaccharides by reductive amination in the presence of sodium cyanoborohydride. Fluorescence correlation spectroscopy, atomic force microscopy, and size exclusion chromatography were used to demonstrate that the conformations of the polysaccharides schizophyllan, polygalacturonic acid (PGUA), succinoglycan, and several dextrans were maintained following the labeling procedure.
Simultaneous interpetrating network based on castor oil elastomers and polystyrene. III. Morphology and glass transition behavior (1979)

Abstract Electron microscopy and dynamic mechanical spectroscopy (DMS) techniques were used to study the morphology and glass transition behavior of simultaneous interpenetrating networks (SIN's), based on three different castor oil derived elastomers, and polystyrene (PS) plastic erosslinked with 1 percent divinyl benzene. The castor oil elastomers consisted of either the sebacic acid polyester, 2,4‐tolylene diisocyanate polyurethane, or the mixed poly(ester‐urethane). Emphasis was placed on two compositions having 10 and 40 percent elastomer contents by weight of each type, the remainder being PS. In all cases, a two‐phase morphology emerged. With the 10 percent elastomer composition, the use of vigorous stirring during the early stages of reaction resulted in materials having the crosslinked polystyrene as the continuous phase and elastomer domains (ranging from 100 to 8000 nm in size) as the discontinuous phase. The elastomer domains contained a polystyrene cellular structure, with the polystyrene cell sizes ranging from 50 to 300 nm size. Several examples showed morphologies resembling high impact polystyrene. Materials having a 40 percent elastomer content always showed a continuous phase of castor oil elastomer, with the PS displaying a bimodal size cellular structure. Domain sizes ranged from 10 to 860 nm. The DMS studies showed two well‐defined glass transitions near their respective homopolymer glass transitions, but shifted inwards to greater or lesser extents indicating some molecular mixing between the two polymers. The glass transition of the pure elastomer phase occurred at −66°C for the castor oil polyester elastomer, −4°C for the castor oil polyurethane elastomer and −50°C for the castor oil poly(ester‐urethane) elastomer. Phase separation in these materials is postulated to occur by two mechanisms: (1) multiple precipitation of polystyrene chains at progressive levels of polymerization and (2) microsyneresis processes. The thermodynamics of mixing and phase separation in polymerizing SIN's is examined in some detail.
The UH‐60A Black Hawk: A World‐wide Force Multiplier (1982)

The UH‐60A BLACK HAWK helicopter, Fig. 1 , is the US Army's first true squad carrying assault helicopter. Its primary mission is to transport infantry units into combat, re‐supply those units while in combat, and perform the associated functions of aeromedical evacuation and repositioning of reserves.
Effect of Agitation, Sampling Location and Protective Films on Light‐Induced Riboflavin Loss in Skim Milk (1988)

ABSTRACT Photodegradation of riboflavin in skim milk as influenced by continuous agitation, location within the container and protective films was studied. High performance liquid chromatography was used to monitor the riboflavin concentration in the milk. Retention of riboflavin in light‐exposed, continuously agitated milk samples was significantly lower than in unagitated samples. Sampling positions within blow‐molded polyethylene milk containers also had a significant effect on light‐induced riboflavin loss. After 5 days of light exposure, riboflavin retention at the top of the unagitated milk containers averaged 58% compared to 92% retention for milk located at the bottom of the containers. Metallized‐oriented, polyethylene‐terephthalate films used as overwraps decreased penetration of visible light into milk samples and decreased the riboflavin photodegradation.
Growth of rho 0 human Namalwa cells lacking oxidative phosphorylation can be sustained by redox compounds potassium ferricyanide or coenzyme Q10 putatively acting through the plasma membrane oxidase. (1993)

Pyruvate is conventionally used as a key growth supplement for mammalian rho 0 cells that lack mitochondrial DNA and are thereby devoid of oxidative phosphorylation. We have tested the proposition that cultured rho 0 human cells can be grown using redox compounds other than pyruvate. The results show that potassium ferricyanide and coenzyme Q10 can each be used to replace pyruvate to support the growth of rho 0 Namalwa cells (a lymphoblastoid cell line). Ferricyanide and coenzyme Q10 have both been reported as substrates for a plasma membrane NADH oxidase system which is capable of re-oxidising cytosolic NADH to NAD+. These compounds are also known to stimulate the activity of this enzyme system. We interpret our data to indicate that redox support for growth of rho 0 human cells can be achieved by external electron acceptors such as ferricyanide (a plasma membrane impermeant compound), or coenzyme Q10 (an integral component of the plasma membrane oxidase), through the enhanced conversion of cytosolic NADH to NAD+. This re-oxidation of NADH enables glycolysis to function efficiently as the sole source of cellular ATP, in the absence of mitochondrial oxidative phosphorylation in rho 0 cells. This has important implications for the development of new strategies for the amelioration of the bioenergy decline that occurs in mitochondrial disease and during the human ageing process.
Flow-noise and turbulence in two tidal channels (2014)

Flow-noise resulting from oceanic turbulence and interactions with pressure-sensitive transducers can interfere with ambient noise measurements. This noise source is particularly important in low-frequency measurements (f < 100 Hz) and in highly turbulent environments such as tidal channels. This work presents measurements made in the Chacao Channel, Chile, and in Admiralty Inlet, Puget Sound, WA. In both environments, peak currents exceed 3 m/s and pressure spectral densities attributed to flow-noise are observed at frequencies up to 500 Hz. At 20 Hz, flow-noise exceeds mean slack noise levels by more than 50 dB. Two semi-empirical flow-noise models are developed and applied to predict flow-noise at frequencies from 20 to 500 Hz using measurements of current velocity and turbulence. The first model directly applies mean velocity and turbulence spectra while the second model relies on scaling arguments that relate turbulent dissipation to the mean velocity. Both models, based on prior formulations for infrasonic (f < 20 Hz) flow-noise, agree well with observations in Chacao Channel. In Admiralty Inlet, good agreement is shown only with the model that applies mean velocity and turbulence spectra, as the measured turbulence violates the scaling assumption in the second model.
Driver Performance While Using A Cellular Telephone Interface To A Traveler Information System (2005)

The growing availability of in-vehicle technology to acquire and communicate information has proven to be advantageous for motorists. Mobile telephones allow motorists to maintain critical communication between personal and business contacts. Along with the advantages of in-vehicle information dissemination, the communication technologies and their user interfaces may have created a potentially unsafe environment for motorists. Several studies during the past decade have analyzed the effects of using mobile telephones while driving. Results from these studies have indicated that the use of cell phones while driving, whether dialing, answering, or conducting mobile telephone calls, may add a significant increment of risk to the driving task. Studies have found that making a call during a trip may more than triple the risk of a crash. Recent studies have reported that hands-free cell phones have at least as great a risk factor as hand-held phones. It appears that the increased driving risk associated with cell phone use may be attributed primarily to cognitive and attentional factors rather than manual manipulation of the instrument. Recently many states have implemented a Dial traveler information system. This system allows motorists to conveniently obtain advanced information on road conditions, adverse weather, traffic incidents, and construction along their planned route by dialing 511 on their telephones. Providers of the 511 system have emphasized that drivers should obtain this information prior to departure or park their cars safely on the route to make the call. Many drivers, however, access the system to update their travel information while they are driving. No studies to date have examined the safety of using mobile telephones to acquire such travel information. The study referred to in this document analyzed driving performance and situation awareness while subjects accessed the Montana Department of Transportation’s 511 traveler information system via a cellular telephone. Data were collected using the Western Transportation Institute's Driving Simulation Laboratory. Performance on the primary tasks of driving (e.g., lane and speed maintenance) was found to be unaffected by interacting with the cell phone. Yet the tasks that require more prompt response times (e.g., avoiding collisions during unexpected conflicts) were degraded by the use of a cell phone, regardless of the type of instrument used. It appeared that drivers were less aware of their surroundings when interacting with the 511 traveler information system while using a cellular phone and driving. Drivers who communicated with 511 performed more poorly in recalling target objects in the environment than did their counterparts without communication tasks. This reduction in situation awareness could largely explain the increased braking responses and higher number of collisions.
Process modeling and optimization of industrial ethylene oxide reactor by integrating support vector regression and genetic algorithm (2009)

Abstract This article presents an artificial intelligence‐based process modeling and optimization strategies, namely support vector regression–genetic algorithm (SVR‐GA) for modeling and optimization of catalytic industrial ethylene oxide (EO) reactor. In the SVR‐GA approach, an SVR model is constructed for correlating process data comprising values of operating and performance variables. Next, model inputs describing process operating variables are optimized using Genetic Algorithm (GAs) with a view to maximize the process performance. The GA possesses certain unique advantages over the commonly used gradient‐based deterministic optimization algorithms The SVR‐GA is a new strategy for chemical process modeling and optimization. The major advantage of the strategies is that modeling and optimization can be conducted exclusively from the historic process data wherein the detailed knowledge of process phenomenology (reaction mechanism, kinetics, etc.) is not required. Using SVR‐GA strategy, a number of sets of optimized operating conditions leading to maximized EO production and catalyst selectivity were obtained. The optimized solutions when verified in actual plant resulted in a significant improvement in the EO production rate and catalyst selectivity.
Immobilization of Enzymes on Electrodes (2006)

This chapter focuses on the four main immobilization techniques used in the development of enzyme electrodes: adsorption, entrapment, covalent coupling, and cross-linking. The performance of the immobilization method depends on the enzyme and each method has both advantages and drawbacks. Loss of the activity results from the change in enzyme conformation depending on the method of immobilization as well as modification of the microenvironment (i.e., local pH of the enzyme). The activity of the immobilized enzyme decreases as a result of barrier of diffusion, which slows down or prevents the substrate from reaching the active site of the enzyme. The development and the characteristics of an acetylcholinesterase biosensor are described
Oxidation of propene by molecular oxygen over Ti-modified silicalite catalysts (2001)

Ti-modified high silica zeolite with an Si/Al ratio of 1900 was found to be effective for the oxidation of propene to oxygenates such as propene oxide, in the presence of molecular oxygen at 573 K.
Chordomas of the mediastinum: Clinicopathologic, immunohistochemical, and ultrastructural study of six cases presenting as posterior mediastinal masses (1995)

Six cases of chordomas presenting as primary posterior mediastinal tumors are described. Three patients were female, and three were male between the ages of 8 and 65 years (mean, 40.6 years). In all cases, the tumors presented radiographically as relatively well-circumscribed, encapsulated soft tissue masses that did not seem to be related to the thoracic or dorsal spine. Only in one case, focal infiltration of bone at the level of T6-T7 was observed at the time of surgery. Histologically, the lesions showed a spectrum of features that ranged from sheets and cords of large cells with abundant vacuolated cytoplasm to small, stellate cells embedded within an abundant mucoid matrix. In one case, the cell population showed more pronounced nuclear atypia with loss of cytoplasmic vacuolization, frequent mitotic figures, necrosis, and solid areas characterized by a perivascular distribution of atypical spindle cells set against a myxoid stroma. Another case showed features of chondroid chordoma, with an immature chondroid-appearing matrix surrounding the atypical tumor cells. Immunohistochemical studies in all cases showed positive staining of the tumor cells with CAM 5.2 and broad-spectrum keratin, epithelial membrane antigen (EMA) and vimentin, and, to a lesser extent, with S-100 protein. Stains for muscle actin, carcinoembryonic antigen (CEA), and desmin were negative. Ultrastructural examination in two cases showed a spectrum of features that varied from large cells with abundant cytoplasm containing scattered ribosomes, glycogen granules, Golgi apparatti, abundant intermediate filaments, and small lumen formation with immature microvilli to smaller cells with elongated cytoplasmic processes, fewer intermediate filaments, rare desmosome type intercellular junctions, and complexes of mitochondria/rough endoplasmic reticulum. On clinical follow-up, two patients died with metastases to the lungs, chest wall, and liver from 1 to 3 years after diagnosis, and two patients are alive and well without evidence of disease after 3 and 16 years. Chordoma should be entertained in the differential diagnosis of posterior mediastinal tumors. Application of immunohistochemical stains or electron microscopy will be of aid in separating them from other conditions that may histologically closely resemble these lesions.
Laser-induced forward Transfer: a Direct-writing Technique for Biosensors Preparation (2006)

** * * , ** * The focusing power of lasers make them adequate tools for patterning applications that require high levels of spatial resolution. Laser-induced forward transfer (LIFT) is a direct-writing technique allowing the deposition of tiny amounts of material from a donor thin film through the action of a pulsed laser beam. Although LIFT was originally developed to operate with solid films, it has been demonstrated that deposition is also viable from liquid films. In this case the transferred material is not vaporized; rather, a small amount of liquid is directly ejected from the film to the receptor substrate, where it deposits in the form of a microdroplet. This makes LIFT adequate for biosensors preparation, since biological solutions can be transferred onto solid substrates to produce micrometric patterns of biomolecules. In this case, the liquid solvent acts as transport vector of the biomolecules. The viability of the technique has been demonstrated through the preparation of functional biosensors showing similar performances and higher scales of integration than those prepared through more conventional techniques.
Selective Loss of Fibrinogen Clotting in a Loop-less Thrombin (1997)

The autolysis loop of thrombin comprises nine residues, from Glu146 to Lys149e, five of which (Ala149a-Lys149e) are inserted relative to trypsin and chymotrypsin. Deletion of the insertion Ala149a-Lys149e causes no significant change in the properties of the enzyme, except for a slight enhancement of protein C activation. Deletion of the entire Glu146-Lys149e loop, however, reduces fibrinogen clotting 240-fold, but decreases protein C activation only 2-fold. This loop-less mutant is de facto an exclusive activator of protein C, having lost the primary procoagulant function of thrombin. Because the autolysis loop affects fibrinogen binding, but not protein C activation, it provides a target for new drugs designed to suppress exclusively the procoagulant activity of thrombin.
Half-Cell Ion Concentration Polarization on Nafion-Coated Electrode (2018)

On ion-selective membranes, cation/anion-selective transport under electric field initiates ion concentration polarization (ICP); ion concentration increases at one side of the membrane (ion enrichment), whereas it decreases at the other side (ion depletion). This polarization always occurs as the pair of ion enrichment and ion depletion. Departing from such pair generation, we demonstrate that only half of ICP (either ion enrichment or ion depletion) can be solitary on a Nafion-coated electrode. Current-voltage-time responses and conductance measurement capture this half-cell ICP with qualitative in situ pH/ion concentration visualization. In this half-cell, ion depletion hinders an ion flux, whereas ion enrichment facilitates the flux, so a diode-like current rectification is observed even in high-voltage regime (<±200 V) with a rectification factor up to 500. The results in this work give us deeper understanding about ICP on the electrodes and also open the possibility to use half-cell ICP as a high-voltage ionic diode and related sensing/energy applications.
Transgenic Tobacco Plants Expressing the Drosophila Polycomb (Pc) Chromodomain Show Developmental Alterations: Possible Role of Pc Chromodomain Proteins in Chromatin-Mediated Gene Regulation in Plants (1999)

The chromodomain of the Drosophila Polycomb (Pc) protein has been introduced into tobacco nuclei to determine its location in the nucleus and its effect on plant development. Pc is a repressor of homeotic Drosophila genes that shares a well-conserved, although not identical, chromodomain with a structural heterochromatin component, Heterochromatin Protein 1. The chromodomains might therefore play a common role in chromatin repression. An analysis of transgenic plants expressing the Pc chromodomain, which was linked to the green fluorescent protein, suggested that the Pc chromodomain has distinct target regions in the plant genome. Transgenic plants expressing the Pc chromodomain had phenotypic abnormalities in their leaves and flowers, indicating a disruption in development. In axillary shoot buds of plants displaying altered leaf phenotypes, enhanced expression of a homeodomain gene, which is downregulated in wild-type leaves, was found. In Drosophila, Pc has been shown to possess distinct chromosome binding activity and to be involved in the regulation of development-specific genes. Our results support the assumptions that the heterologous chromodomain affects related functions in Drosophila and in plants, and that chromatin modification mechanisms are involved in the regulation of certain plant genes, in a manner similar to chromatin-mediated gene regulation in Drosophila.
The Small GTP-Binding Protein TC10 Promotes Nerve Elongation in Neuronal Cells, and Its Expression Is induced during Nerve Regeneration in Rats (2000)

We have made a rat cDNA library using nerve-transected hypoglossal nuclei. Using this library, we performed expressed-sequence tag analysis coupled with in situ hybridization to identify genes whose expression is altered in response to nerve injury. In this gene screening, a member of Rho family GTPases, TC10, which had not yet been characterized in neuronal cells, was identified. TC10 mRNA expression was very low in normal motor neurons; however, axotomy induced its expression dramatically. Other family members such as RhoA, Rac1, and Cdc42 were moderately expressed in normal motor neurons and showed slight upregulation after axotomy. The expression level of TC10 mRNA was low in the embryonic brain and gradually increased with development. However, the expression of TC10 mRNA in the adult brain was lower and more restricted than that of RhoA, Rac1, and Cdc42. Cultured dorsal root ganglia exhibited dramatic neurite extension secondary to adenovirus-mediated expression of TC10. It can be concluded that although TC10 expression is lower in developing and mature motor neurons compared with other Rho family members, TC10 expression is induced by nerve injury to play a crucial role in nerve regeneration, particularly neurite elongation, in cooperation with other family members.