gebhart/patrepeval huggingface dataset:
Association of depressive disorders, depression characteristics and antidepressant medication with inflammation (2012)

Growing evidence suggests that immune dysregulation may be involved in depressive disorders, but the exact nature of this association is still unknown and may be restricted to specific subgroups. This study examines the association between depressive disorders, depression characteristics and antidepressant medication with inflammation in a large cohort of controls and depressed persons, taking possible sex differences and important confounding factors into account. Persons (18-65 years) with a current (N = 1132) or remitted (N = 789) depressive disorder according to DSM-IV criteria and healthy controls (N = 494) were selected from the Netherlands Study of Depression and Anxiety. Assessments included clinical characteristics (severity, duration and age of onset), use of antidepressant medication and inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α)). After adjustment for sociodemographics, currently depressed men, but not women, had higher levels of CRP (1.33 versus 0.92 mg l(-1), P<0.001, Cohen's d = 0.32) and IL-6 (0.88 versus 0.72 pg ml(-1), P = 0.01, Cohen's d = 0.23) than non-depressed peers. Associations reduced after considering lifestyle and disease indicators--especially body mass index--but remained significant for CRP. After full adjustment, highest inflammation levels were found in depressed men with an older age of depression onset (CRP, TNF-α). Furthermore, inflammation was increased in men using serotonin-norepinephrine reuptake inhibitors (CRP, IL-6) and in men and women using tri- or tetracyclic antidepressants (CRP), but decreased among men using selective serotonin reuptake inhibitors (IL-6). In conclusion, elevated inflammation was confirmed in depressed men, especially those with a late-onset depression. Specific antidepressants may differ in their effects on inflammation.
Failure detection in linear systems (1973)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1973.
Voltage and reactive power control in MV networks integrating MicroGrids (2007)

The main objective of this paper is to describe a strategy to deal with the voltage/reactive power problem for a MV distribution network integrating microgrids. The global problem, concerning all voltage levels, is detailed here and will imply the optimization of operating conditions by using the control capabilities of power electronic interfaces from DG sources, OLTCs and microgrids, through the application of an EPSO optimization algorithm.
AC conductivity of carbon fiber–polymer matrix composites at the percolation threshold (2002)

Abstract This paper reports results on experimental investigation of the conductivity behavior of carbon fiber filled polymer composites at the percolation threshold. Two types of carbon fiber‐epoxy matrix composites have been studied and comparison of the measured data has been made. These two types of composites differ in the surface modification of carbon fibers (in one case the surface of carbon fibers is covered with polymer beads using the microencapsulation technology, in the other their surface stayed unmodified). Experimental data reveal that surface modification of carbon fibers influences greatly the DC conductivity (percolation threshold moves to higher concentrations) but does not influence the AC electrical properties. From the frequency dependence of conductivity upon fiber concentration it becomes clear that it is not possible to predict the high frequency conductivity (electromagnetic interference shielding properties) based on the DC conductivity. Percolation behavior of conductivity as a function of conductive filler concentration is typical only for DC or low frequency AC conductivity. The percolation threshold gradually vanishes for high frequencies of electromagnetic field. The temperature dependence of electrical properties has also been studied. Composites with concentration near the percolation threshold show the switch‐off effect (at the specific temperature the DC conductivity drops by several orders of magnitude). This switch‐off effect does not occur for high frequency AC conductivity.
A phase I clinical trial of a ribozyme-based angiogenesis inhibitor targeting vascular endothelial growth factor receptor-1 for patients with refractory solid tumors (2005)

Angiozyme was well tolerated with satisfactory pharmacokinetic variables for daily s.c. dosing. Results have provided the basis for subsequent clinical trials of this first-of-class biologically targeted therapeutic.
A Novel Bayesian Optimization Framework for Computationally Expensive Optimization Problem in Tight Oil Reservoirs (2017)

Abstract Multi-well pad has been considered as the most efficient horizontal-well drilling technique in unconventional reservoir development since it not only greatly maximizes the oil production, but also significantly reduces environmental impact and operation costs by drilling group of wells on a single pad. To optimize both hydraulic fracture parameters of each well and well placement simultaneously is still largely unexplored and remains to be a challenging task. Conventional optimization techniques, such as genetic algorithm, particle swarm optimization, and differential evolution algorithm are inadequate to optimize production performance in the multi-well pad, because it may take hours to days to run a single reservoir simulation, leading to an unaffordable computational cost for the optimization processes. To speed up the search process of global optimization in reservoir simulations, a novel optimization framework for computationally expensive simulations is developed based on Bayesian optimization algorithm. The newly developed optimization algorithm constructs a probabilistic model for the objective function and then exploits this model to make decisions about where in search space to next evaluate the function. In this study, Gaussian Process (GP) is utilized to construct the prior distribution over the objective function. Then, the posterior over functions is obtained based on the prior distribution and evaluations of objective functions. Finally, acquisition function is developed through maximizing the expected improvement over the current best from the posterior, allowing us to determine the next point to evaluate in search space. It is shown that GP Bayesian optimization framework can successfully optimize the hydraulic fracture parameters and horizontal well placement simultaneously in tight oil reservoirs. 19 parameters involve well spacing, well length, fracture spacing, fracture half-length, and fracture conductivity in a four-well pad were optimized and a high net present value (NPV) was achieved. The oil recovery and NPV of the optimum scenario derived through the Bayesian optimization technique are increased by 36.0% and 55.7% respectively in comparison with a field reference case. The proposed Bayesian optimization framework is found to be a promising and efficient optimization strategy, which takes full advantage of the information available from previous evaluations of objective function, in handling the computationally expensive optimization problems.
Managing nonalcoholic fatty liver disease: recommendations for family physicians. (2007)

Although most patients with NAFLD have a benign course, some progress to NASH, liver cirrhosis, and hepatocellular carcinoma. These patients should be carefully monitored for progression of disease and treated for associated metabolic disturbances. An integrated approach to care is essential.
Laser action in chromium-activated forsterite for near infrared excitation (1988)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text V. Petricevic, S. K. Gayen, and R. R. Alfano, "Laser action in chromium-activated forsterite for near infrared excitation," Appl. Opt. 27, 4162-4163 (1988) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Molecular characterization of Plasmodium falciparum S-adenosylmethionine synthetase (1999)

S-Adenosylmethionine (AdoMet) synthetase (SAMS: EC 2.5.1.6) catalyses the formation of AdoMet from methionine and ATP. We have cloned a gene for Plasmodium falciparum AdoMet synthetase (PfSAMS) (GenBank accession no. AF097923), consisting of 1209 base pairs with no introns. The gene encodes a polypeptide (PfSAMS) of 402 amino acids with a molecular mass of 44844 Da, and has an overall base composition of 67% A+T. PfSAMS is probably a single copy gene, and was mapped to chromosome 9. The PfSAMS protein is highly homologous to all other SAMS, including a conserved motif for the phosphate-binding P-loop, HGGGAFSGKD, and the signature hexapeptide, GAGDQG. All the active-site amino acids for the binding of ADP, P(i) and metal ions are similarly preserved, matching entirely those of human hepatic SAMS and Escherichia coli SAMS. Molecular modelling of PfSAMS guided by the X-ray crystal structure of E. coli SAMS indicates that PfSAMS binds ATP/Mg(2+) in a manner similar to that seen in the E. coli SAMS structure. However, the PfSAMS model shows that it can not form tetramers as does E. coli SAMS, and is probably a dimer instead. There was a differential sensitivity towards the inhibition by cycloleucine between the expressed PfSAMS and the human hepatic SAMS with K(i) values of 17 and 10 mM, respectively. Based on phylogenetic analysis using protein parsimony and neighbour-joining algorithms, the malarial PfSAMS is closely related to SAMS of other protozoans and plants.
Reconstructive elasticity imaging for large deformations (1999)

A method is presented to reconstruct the elastic modulus of soft tissue based on ultrasonic displacement and strain images for comparatively large deformations. If the average deformation is too large to be described with a linear elastic model, nonlinear displacement-strain relations must be used and the mechanical equilibrium equations must include high order spatial derivatives of the displacement. Numerical methods were developed to reduce error propagation in reconstruction algorithms, including these higher order derivatives. Problems arising with the methods, as well as results using ultrasound measurements on gel-based, tissue equivalent phantoms, are given. Comparison to reconstructions using a linear elastic model shows that equivalent image quality can be produced with algorithms appropriate for finite amplitude deformations.
A Technique to Align Liquid Crystals Based on Bulk-Induced Photo-Polymerization (1996)

Abstract A technique based on bulk-induced alignment of liquid crystals by photo-polymerization to produce uniform planar and homeotropic orientation of liquid crystals is presented. The liquid crystal-photopolymer mixture is cured with linearly polarized UV-light in the isotropic phase. This technique obviates the need to give any special treatment to the bounding substrate and as such is independent of the nature of the substrate. This has given rise to possibilities of using liquid crystals for storing information with a high degree of spatial resolution of 10–20μm and has been used to generate patterned orientation of liquid crystals. The homeotropic alignment in the smectic C phase has opened up new possibilities to make storage displays. The surface studies of the photopolymer aligned substrate with a Scanning Tunneling Microscope suggest that the surface modification dominates the alignment of liquid crystals.
Feature extraction for hyperspectral data based on MNF and singular value decomposition (2013)

Feature extraction acts a crucial role in application and research of hyperspectral data and minimum noise fraction (MNF) is one of the most common methods in feature extraction. Estimation of noise covariance matrix is an inevitable step of MNF, but it would bring error which would lead imprecise while using the first some components of MNF transform to represent original data. To solve the problem above, a feature extraction method based on MNF and singular value decomposition was proposed. MNF was first acted on data, then, the transformed data were decomposed by singular value decomposition, and the first some components of reconstruction used singular values and singular vectors were selected as feature components of original data. Experiments with factual hyperspectral data indicated that classified precision after feature extraction by the proposed method was higher than those by traditional MNF in three classified methods and different dimension.
A high-speed network interface for distributed-memory systems (1997)

Distributed-memory systems have traditionally had great difficulty performing network I/O at rates proportional to their computational power. The problem is that the network interface has to support network I/O for a supercomputer, using computational and memory bandwidth resources similar to those of a workstation. As a result, the network interface becomes a bottleneck. In this article we present an I/O architecture that addresses these problems and supports high-speed network I/O on distributed-memory systems. The key to good performance is to partition the work appropriately between the system and the network interface. Some communication tasks are performed on the distributed-memory parallel system, since it is more powerful and less likely to become a bottleneck than the network interface. Tasks that do not parallelize well are performed on the network interface, and hardware support is provided for the most time-critical operations. This architecture has been implemented for the iWarp distributed-memory system and has been used by a number of applications. We describe this implementaiton, present performance results, and use application examples to validated the main features of the I/O architecture.
초등학교 수업을 위한 문제중심학습(PBL)의 교수학습 과정 모형 연구 (2004)

현실적 필요성은 증가하고 있으나 자기 주도성이나 학습능력이 부족한 초등학교 학생들에게는 어렵게 생각되어 초등교육 현장에서는 아직 쉽게 적용되지 못하고 있는 문제중심학습 (PBL)의 교수학습 과정을 구체화하여 초등학교 교실에서 적용 가능한 문제중심학습모형을 구축하고자 하는 것이 본 연구의 목적이다. 기존의 여러 문제중심학습과정 관련 문헌들로부터 공통적으로 중시되는 단계들을 중심으로 하여 1) 문제 만나기, 2) 문제 해결계획 세우기, 3) 탐색하기, 4) 문제해결책 만들기, 5) 발표 및 평가하기 의 절차를 추출하였으며, 각 단계의 의미 및 범위, 그리고 주요활동들이 어떻게 이루어져야 하는지를 구체적으로 제시, 논의하였다. 또한 이러한 과정을 초등 6학년 과학에서 ‘태풍’을 주제로 하여 ‘일기예보’ 단원을 위해 개발한 문제중심학습의 예를 통해 구체화하였다. 특히 어린 학습자들이 문제중심학습의 일련의 과정을 잘 수행하여 본래 문제중심학습의 의도에서도 벗어나지 않도록 하기 위해 교사가 안내자, 즉 코치로서의 역할을 어떻게 해야 하는지를 구체적인 활동 및 교사 발문의 예시를 통해 제시하였다.
Solvent-assisted poly(vinyl alcohol) gelated crystalline colloidal array photonic crystals (2010)

We have prepared a solvent-assisted poly(vinyl alcohol) (PVA) gelated crystalline colloidal array (GCCA) photonic crystal material. PVA GCCA was formed by utilizing a well-known freeze-thawing method while the crystalline colloidal array (CCA) was physically immobilized within the PVA hydrogel network. This photonic crystal material could be conveniently fabricated, shaped as needed and efficiently diffracts visible light. The diffraction wavelength can be tuned anywhere within the visible spectrum by simply varying the CCA concentration or stretching the sample. The GCCA demonstrated sol–gel reversible behaviour as the temperature was cycled. It has been observed that the GCCA maintained its ability of diffraction after rehydration, and the sample could be stored for long periods of time at room temperature.
Vehicle cabin safety alert system (2015)

The Oxygen depletion and sudden rise in temperature level inside the vehicle cabin has a greater impact on both humans and animals all over the world. The Reduced oxygen levels inside the vehicle cabin will lead to drowsiness, fatigue due to which it led to many fatal road accidents which occurs every year, even Exhaust Gas Suicide occurs mainly due to poisonous gases entering into the vehicle cabin. Another significant rise of deaths of children and pet animals every year is because of heatstroke which occurs due to increase in temperature level inside the cabin. Therefore this paper aims to develop a smart monitoring system which would monitor oxygen concentration, temperature and humidity continuously thereby adding comfort, health, safety and security of the passengers inside the vehicle even if the vehicle is turned on or off. Thus, Protection and safekeeping plays a key role in vehicle cabin monitoring system, this effective solution will help to deliver better safety and security while travelling regardless of the vehicle being old or new.
The New Oxford American dictionary (2002)

Preface to the Third Edition Preface to the First Edition Introduction How to Use This Dictionary Key to the Pronunciations Key to the Abbreviations The New Oxford American Dictionary Ready Reference (in center) Illustration Credits (at back)
An energy-efficient non-volatile in-memory accelerator for sparse-representation based face recognition (2015)

Data analytics such as face recognition involves large volume of image data, and hence leads to grand challenge on mobile platform design with strict power requirement. Emerging non-volatile STT-MRAM has the minimum leakage power and comparable speed to SRAM, and hence is considered as a promising candidate for data-oriented mobile computing. However, there exists significantly higher write-energy for STT-MRAM when compared to the SRAM. Based on the use of STT-MRAM, this paper introduces an energy-efficient non-volatile in-memory accelerator for a sparse-representation based face recognition algorithm. We find that by projecting high-dimension image data to much lower dimension, the current scaling for STT-MRAM write operation can be applied aggressively, which leads to significant power reduction yet maintains quality-of-service for face recognition. Specifically, compared to a baseline with SRAM, leakage power and dynamic power are reduced by 91.4% and 79% respectively with only slight compromise on recognition rate.
Web Page Scripting Techniques (1996)

This is the only book to help Web publishers bring all of the popular Web scripting techniques into to their Web sites with a design sensibility. Simple step-by-step information on deconstructing Web pages using the latest techniques in scripting. -- Expert advice teaches Web publishers which coding structure to use and when -- Hundreds of specially selected Web pages broken down into easy to understand tutorials -- CD-ROM includes hundreds of Web page templates, HTML code ideas, and scripting procedures
Ro 15-8081 in osteoarthritis of hip and knee: a double-blind placebo-controlled multicentre dose-ranging study on analgesia (1996)

Ro 15-8081, a substituted cyclohexanol hydrochloride, inhibits the re-uptake of norepinephrine and of serotonin. Its antinociceptive properties have been demonstrated in animals and then confirmed in humans after single-dose administration. The objective was to determine the analgesic efficacy and the safety of Ro 15-8081 in osteoarthritis of the hip and knee (femoro-tibial location) after multiple-dose application. The design for studying dosage employed 5 parallel groups in an international multicenter, double-blind, randomized trial having a duration of 2 weeks. Drugs studied were: 20 mg Ro 15-8081 (divided into 2 doses), 50 mg Ro 15-8081 (divided into 2 doses), 100 mg Ro 15-8081 (divided into 2 doses), placebo twice daily or 20 mg/day piroxicam (piroxicam in the morning and placebo in the evening). Piroxicam was used as a reference drug in order to validate clinical testing. Assessment criteria were pain (100-mm VAS) and function (Lequesne's index). A responder (main assessment criterion) was defined as a patient exhibiting a reduction of at least 30% of pain (VAS) during the study (intention-to-treat analysis). A total of 522 patients were enrolled in the study. A clear beneficial effect of piroxicam was observed when compared with placebo (70% and 48% of responders in piroxicam and placebo groups respectively; P < 0.0001). Multigroup comparison showed a statistically significant difference between Ro 15-8081 groups and the placebo group regarding mean change in pain between D1 and Dend and the rate of VAS responders. Comparison (Dunnett's t or chi 2 tests) between each individual Ro 15-8081 and the placebo group reached statistical significance for the 100 mg Ro 15-8081 group (mean change in pain between D1 and Dend: P = 0.05; percentage of responders: P = 0.0008) but no statistically significant difference for the other dosages of Ro 15-8081. Fifty-three patients withdrew from the study because of adverse events and/or inefficacy, mainly in 50 and 100 mg Ro 15-8081 groups and in a dose-related manner. The adverse events which appeared to be drug related were mainly dryness of the mouth, insomnia, headache, constipation, nausea, dizziness, nervousness, palpitation. This study suggests that 100 mg Ro 15-8081 per day divided into 2 doses has (1) an analgesic effect in hip or knee osteoarthritis and (2) poor acceptability in the conditions of the study regimen application.
Molecular cloning of the cDNA for the human U2 snRNA-specific A′ protein (1989)

The A' polypeptide is one of the protein constituents of the U2 snRNP particle. A potentially full-length cDNA clone containing the complete coding sequence for this U2 snRNP-specific protein was isolated by screening of a human lambda gt11 expression vector library with an autoimmune anti-(U1,U2)RNP serum. Monospecific antibodies, eluted from the 140-150 kD fusion protein of this cDNA recombinant, specifically recognized the A' protein on immunoblots and immunoprecipitated U2 snRNP particles from nuclear extracts. The identity of the clone was confirmed by in vitro translation of hybrid-selected mRNA or an RNA transcript synthesized from the cDNA insert. RNA blot analysis showed strong hybridization to a single polyadenylated transcript of 1.3 kb in human cells. The nucleotide sequence of the 1054 bp cDNA contains an open reading frame of 756 bp encoding a polypeptide of 255 amino acids with a predicted molecular weight of 28,444 D. The coding sequence is preceded by a 49 bp 5'-untranslated region and followed by a 226 bp 3'-untranslated region containing a single polyadenylation signal. Most striking feature of the deduced primary structure for the A' protein is a leucine-rich region in the amino-terminal half of the polypeptide. In contrast to the other U2 snRNP-specific protein B", the A' protein does not contain segments homologous to the RNP consensus sequences RNP1 and RNP2, common amino acid motifs found in several RNA-binding proteins. In the A' protein, however, the extremely hydrophilic carboxy terminus may constitute an RNA-binding moiety.
Purification and Properties of Polygalacturonase Produced by Thermophilic Fungus <i>Thermoascus aurantiacus</i> CBMAI-756 on Solid-State Fermentation (2013)

Polygalacturonases are enzymes involved in the degradation of pectic substances, being extensively used in food industries, textile processing, degumming of plant rough fibres, and treatment of pectic wastewaters. Polygalacturonase (PG) production by thermophilic fungus Thermoascus aurantiacus on solid-state fermentation was carried out in culture media containing sugar cane bagasse and orange bagasse in proportions of 30% and 70% (w/w) at 45°C for 4 days. PG obtained was purified by gel filtration and ion-exchange chromatography. The highest activity was found between pH 4.5 and 5.5, and the enzyme preserved more than 80% of its activity at pH values between 5.0 and 6.5. At pH values between 3.0 and 4.5, PG retained about 73% of the original activity, whereas at pH 10.0 it remained around 44%. The optimum temperature was 60-65°C. The enzyme was completely stable when incubated for 1 hour at 50°C. At 55°C and 60°C, the activity decreased 55% and 90%, respectively. The apparent molecular weight was 29.3 kDa, K m of 1.58 mg/mL and V max of 1553.1 μ mol/min/mg. The presence of Zn(+2), Mn(+2), and Hg(+2) inhibited 59%, 77%, and 100% of enzyme activity, respectively. The hydrolysis product suggests that polygalacturonase was shown to be an endo/exoenzyme.