gebhart/patrepeval huggingface dataset:
Clinical features of insulin resistance and beta cell dysfunction and the relationship to type 2 diabetes. (2001)

Type 2 diabetes mellitus is a heterogeneous disorder characterized by varying degrees of impaired insulin secretion and insulin resistance. The metabolic manifestations of insulin resistance include (1) reduced insulin-stimulated glucose uptake, (2) reduced insulin-suppression of endogenous glucose production, and (3) reduced antilipolysis. All of these mechanisms contribute to the hyperglycemis of T2DM, both post-absorptively and postprandially. In addition, insulin resistance is involved in decreaswed insulin-induced vasodilation, dyslipidemia, and platelet hyperaggregability. The pathogenesis of T2DM involves a combination of genetic and environmental factors. Monogenic causes account for only a minority of insulin resistance and beta cell dysfunction. Among environmental factors the most important are obesity, reduced physical activity, and age. Obesity-associated insulin resistance is thought to be mediated mainly by FFAs whose clearance is reduced in subjects with T2DM. A number of clinical tests have been developed to assess insulin sensitivity and beta cell function in vivo. The euglycemic hyperinsulinemic clamp and the hyperglycemic clamp, respectively, represent the gold standard procedures. Recently, indices calculated parameters of the OGTT have been proposed as surrogates for assessing both insulin sensitivity and beta cell function in clinical situations and epidemiologic studies.
Design and fabrication of a micromachined multispectral magnetic resonance imaging agent (2009)

This paper describes the fabrication details of magnetic nano- and microstructures that enable a new class of multispectral magnetic resonance imaging agents. Magnetic field and associated geometrical fabrication constraints particular to these new multispectral contrast agents are described, and fabrication schemes based on both electrochemical deposition and thermal evaporation are presented. Relative advantages and disadvantages of top-down microfabrication approaches versus traditional bottom-up chemical synthesis routes are discussed with a focus on trade-offs between resulting microparticle functionality and fabrication process economy. It is shown that large numbers of contrast agent nano- or microstructures can be simultaneously fabricated, suggesting that top-down microfabricated contrast agents may represent an economical, attractive alternative to those based on chemically synthesized molecules or nanoparticles.
Prognostic Value of Immunophenotyping in Multiple Myeloma: A Study by the PETHEMA/GEM Cooperative Study Groups on Patients Uniformly Treated With High-Dose Therapy (2008)

To the best of our knowledge, this is the first prospective analysis in which the prognostic impact of a relatively high number of antigenic markers has been simultaneously analyzed in a large series of uniformly treated patients, showing that the expression of several antigens (particularly CD28 and CD117) on bone marrow plasma cells from patients with MM can help to identify patients at high risk of progression.
Anastomotic leaks after esophagectomy for esophageal cancer: a comparison of thoracic and cervical anastomoses. (2001)

In our experience cervical esophagogastric anastomoses do not have a higher incidence of leaks than thoracic anastomoses.
Study on the efficiency of electric stimulation of the pelvic floor. (1976)

The continuous electric stimulation of the anal sphincter leads to the onset of a very quick fatigue of the muscle, with a progressive decrease of the amplitude of contraction after 15 min of stimulation. Under the same experimental conditions intermittent stimulation leads to a sustained contraction amplitude. Ts and Tr combinations that can give efficiency rates of contraction above 80 per cent were defined. The results of this study could be applied when intermittent electric stimulation of the pelvic floor is indicated for the treatment of anal or urinary incontinence.
The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site (2015)

Proenzyme maturation is a general mechanism to control the activation of enzymes. Catalytically active members of the A Disintegrin And Metalloprotease (ADAM) family of membrane-anchored metalloproteases are synthesized as proenzymes, in which the latency is maintained by their autoinhibitory pro-domains. A proteolytic processing then transforms the proenzyme into a catalytically active form. The removal of the pro-domain of ADAMs is currently thought to depend on processing at a canonical consensus site for the proprotein convertase Furin (RXXR) between the pro- and the catalytic domain. Here, we demonstrate that this previously described canonical site is a secondary cleavage site to a prerequisite cleavage in a newly characterized upstream PC site embedded within the pro-domain sequence. The novel upstream regulatory site is important for the maturation of several ADAM proenzymes. Mutations in the upstream regulatory site of ADAM17, ADAM10, and ADAM9 do not prevent pro-domain processing between the pro- and metalloprotease domain, but nevertheless, cause significantly reduced catalytic activity. Thus, our results have uncovered a novel functionally relevant PC processing site in the N-terminal part of the pro-domain that is important for the activation of these ADAMs. These results suggest that the novel PC site is part of a general mechanism underlying proenzyme maturation of ADAMs that is independent of processing at the previously identified canonical Furin cleavage site.
RELATING CELLULAR ASSOCIATION WITH LIPOSOME CYTOTOXICITY IN HUMAN ENDOTHELIAL CELLS (2016)

INTRODUCTION Interactions with the endothelium play a key role in the behaviour of intravenously administered nanoparticle drug carriers [1] . Hence, quantifying cellular association (membrane adhesion and cell internalization) of liposomes with endothelial cells is an effective screening method of biocompatibility and success of new drug carriers. Current methods are inaccurate as concentration does not necessarily equate to local cellular association. The focus of this experiment is to quantify the cellular association between liposomes and two types of human endothelial cells and compare the associations with cells’ cytotoxic response. Cellular association of liposomes as well as cell viability were quantified on cellular level at different concentrations of liposomes. METHODS Two different types of cells, Human Umbilical Vein Endothelial cell, which is a common cell type used in vitro studies, and Human MicroVascular Cell, which is more accurate representation of in vivo, were used [2] . HUVEC and HMVEC were cultured and passaged onto chamber slides using standard cell culture techniques. The confluent cells were exposed to fluorescent liposomes with hydrodynamic diameter of 90.4 nm at concentrations ranging from 0.08nM to 8nM for 24 hours, membrane stained with CellMask Deep Red and fixed with paraformaldehyde, following same protocols for both types of cells. Cell viability on exposure to the same concentration range of liposomes was determined using Vialight assay using manufacturer protocols. Z-stacks of the treated cells were obtained using Olympus Fluoview FV1000 confocal microscope. Region of interest, limited by cell membranes, was set using the membrane stain channel using ImageJ. The region of interest was superimposed onto the fluorescent liposome channel to determine exclusively the fluorescence of cell adhered and cell internalized liposomes RESULTS Compared to HUVECs, higher cellular association of liposomes was observed for HMVC as shown in Figure 1. While cellular association of liposomes increased with concentration, cell viability was in the range of 85 to nearly 100% for the concentration range of 0.08-4 nM with no significant difference. Only at 8 nM, cell viability decreased significantly to approximately 62 %. DISCUSSION AND CONCLUSIONS Liposome cellular association provide insight into the cytotoxicity and the endothelial cytotoxicity of the liposomes at low concentration of 8nM raises cautions on documented innocuous properties of liposomes. Cytotoxicity and cellular association upon comparison showed exponential relationship. Because the cytotoxicity and cellular association relationship is exponential, slight over-administration can cause severe toxicity. 8nM is lower than concentration of current intravenous liposome-based drug doxorubicin [3] . High toxicity and exponential relationship raise caution on the importance of proper safe dosage.
Reactions of osmium(IV) complexes of PAC ligands with azide species (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of osmium(IV) complexes of PAC ligands with azide speciesClaudia J. Barner, Terrence J. Collins, Brian E. Mapes, and Bernard D. SantarsieroCite this: Inorg. Chem. 1986, 25, 24, 4322–4323Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://doi.org/10.1021/ic00244a004Request reuse permissionsArticle Views167Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (265 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
DETECTION OF GASEOUS EFFLUENTS FROM AIRBORNE LWIR HYPERSPECTRAL IMAGERY USING PHYSICS-BASED SIGNATURES (2008)

Detection of gaseous effluent plumes from airborne platforms provides a unique challenge to the remote sensing community. The measured signatures are a complicated combination of phenomenology including effects of the atmosphere, spectral characteristics of the background material under the plume, temperature contrast between the gas and the surface, and the concentration of the gas. All of these quantities vary spatially further complicating the detection problem. In complex scenes simple estimation of a “residual” spectrum may not be possible due to the variability in the scene background. A common detection scheme uses a matched filter formalism to compare laboratory-measured gas absorption spectra with measured pixel radiances. This methodology can not account for the variable signature strengths due to concentration path length and temperature contrast, nor does it take into account measured signatures that are observed in both absorption and emission in the same scene. We have developed a physics-based, forward model to predict in-scene signatures covering a wide range in gas / surface properties. This target space is reduced to a set of basis vectors using a geometrical model of the space. Corresponding background basis vectors are derived to describe the non-plume pixels in the image. A Generalized Likelihood Ratio Test is then used to discriminate between plume and non-plume pixels. Several species can be tested for iteratively. The algorithm is applied to airborne LWIR hyperspectral imagery collected by the Airborne Hyperspectral Imager (AHI) over a chemical facility with some ground truth. When compared to results from a clutter matched filter the physics-based signature approach shows significantly improved performance for the data set considered here.
Two-photon<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>E</mml:mi><mml:mn>1</mml:mn></mml:mrow></mml:math>-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>M</mml:mi><mml:mn>1</mml:mn></mml:mrow></mml:math>optical clock (2014)

An allowed E1-M1 excitation scheme creates optical access to the 1S0→3P0 clock transition in group-II-type atoms. This method does not require the hyperfine mixing or application of an external magnetic field of other optical clock systems. The advantages of this technique include a Doppler-free excitation scheme and increased portability with the use of vapor cells. We will discuss technical mechanisms of a monochromatic excitation scheme for a hot E1-M1 clock and briefly discuss a bichromatic scheme to eliminate light shifts. We determine the optimal experimental parameters for Hg, Yb, Ra, Sr, Ba, Ca, Mg, and Be and calculate that neutral Hg has ideal properties for a hot, portable frequency standard.Received 24 April 2014DOI:https://doi.org/10.1103/PhysRevA.90.012523©2014 American Physical Society
Security Actions During Reduction in Workforce Efforts: What To Do When Downsizing (2002)

Abstract Today, companies of every size are relying on Internet and other network connections to support their business. For each of those businesses, information and network security have become increasingly important. Yet, achieving a security level that will adequately protect a business is a difficult task because information security is a multifaceted undertaking. A successful information security program is a continuous improvement project involving people, processes, and technology, all working in unison.
Kinetik der alkalischen Hydrolyse der Halbester von Dicarbonsäure in Elektrolytlösungen (1981)

We’ve built this digital research platform to provide academics everywhere with fast, stable and secure digital access to our library of over 110,000 scholarly books and 800,000 journal articles. We’ve tested the platform in close cooperation with leading academic institutions. If you have any questions or you notice something doesn’t quite work as it should, please visit our <a href="/publishing/faq?lang=en" class="text-primary">Help/FAQ</a> page and let us know.
— enhanced light-matter interactions for lab-on-a-chip applications (2007)

Optical techniques are finding widespread use in analytical chemistry for chemical and bio-chemical analysis. During the past decade, there has been an in- creasing emphasis on miniaturization of chemical anal- ysis systems and naturally this has stimulated a large effort in integrating microfluidics and optics in lab-on- a-chip microsystems. This development is partly defin- ing the emerging field of optofluidics. Scaling analysis and experiments have demonstrated the advantage of micro-scale devices over their macroscopic counterparts for a number of chemical applications. However, from an optical point of view, miniaturized devices suffer dra- matically from the reduced optical path compared to macroscale experiments, e.g. in a cuvette. Obviously, the reduced optical path complicates the application of optical techniques in lab-on-a-chip systems. In this pa- per we theoretically discuss how a strongly dispersive photonic crystal environment may be used to enhance the light-matter interactions, thus potentially compen- sating for the reduced optical path in lab-on-a-chip sys- tems. Combining electromagnetic perturbation theory with full-wave electromagnetic simulations we address the prospects for achieving slow-light enhancement of Beer-Lambert-Bouguer absorption, photonic band-gap based refractometry, and high-Q cavity sensing.
Talbot conditions, Talbot resonators, and first-order systems (2003)

A study of first-order Talbot resonators is presented. The general conditions for Talbot effect in ABCD systems are determined. These conditions are applied to the computation of the diffraction overlapping coefficients between array Gaussian emitters in a general first-order Talbot resonator. Relations on the ray-transfer matrix to generate the symmetric and the totally antisymmetric supermodes of the array are derived. These relations generalize the free-space, round-trip lengths of 1/2 and 1/4 of the Talbot distance. A new type of resonator based on a plano-convex gradient-index rod is proposed.
Temperature gradient transient liquid phase diffusion bonding: A new method for joining advanced materials (1997)

A novel method for transient liquid phase (TLP) diffusion bonding of aluminium based materials has been developed which is capable of reliably providing excellent bonds with parent material shear strengths. This new method relies on imposing a temperature gradient across the bond line during TLP diffusion bonding and this leads to the formation of sinusoidal or cellular interfaces. Consequently, bond strengths are increased, possibly as a result of the higher metal–metal contact along the non-planar interfaces compared with the planar interfaces associated with either conventional TLP or solid state diffusion bonding processes. This paper describes the results achieved, implementing the new method and using copper interlayers, when joining Al–Mg–Si, Al–Li alloys, and an aluminium metal matrix composite with SiC particles. Patent protection has been filed in the UK under UK Patent No. 9709167.2.
Precision wafer bonding process for future cost-effective 3DICs (2015)

A high-precision wafer-to-wafer (W2W) bonding system for three-dimensional integrated circuits (3DICs) fabrication adopting a new precision alignment methodology is proposed. In studying W2W device yield, the authors split the stacking W2W yield formula to better understand the systematic versus random components, and propose that miniaturization yield and wafer stacking yield should be considered separately. Experimental results show that the W2W alignment capability is 250 nm or better, with similar overlay accuracy (|mean| + 3σ) for high-throughput Cu-Cu permanent bonding. These capabilities are key enablers for the future of cost-effective 3DIC manufacturing.
Glass Transition Temperatures and Fermentative Activity of Heat-Treated Commercial Active Dry Yeasts (2000)

Differential scanning calorimetry thermograms of various samples of commercial instant active dry yeasts revealed a clear glass transition typical of amorphous carbohydrates and sugars. The resulting glass transition temperatures were found to decrease with increasing moisture content. The observed glass curve was similar to that of pure trehalose, which is known to accumulate in large amounts in baker's yeast. The effect of heat treatment at various temperatures on the fermentative activity (as measured by the metabolic production of CO(2)) of dry yeast was studied. First-order plots were obtained representing the loss of fermentative activity as a function of heating time at the various temperatures assayed. Significant losses of fermentative activity were observed in vitrified yeast samples. The dependence of rate constants with temperature was found to follow Arrhenius behavior. The relationship between the loss of fermentative activity and glass transition was not verified, and the glass transition was not reflected on the temperature dependence of fermentative activity loss.
Detecting BGP configuration faults with static analysis (2005)

The Internet is composed of many independent autonomous systems (ASes) that exchange reachability information to destinations using the Border Gateway Protocol (BGP). Network operators in each AS configure BGP routers to control the routes that are learned, selected, and announced to other routers. Faults in BGP configuration can cause forwarding loops, packet loss, and unintended paths between hosts, each of which constitutes a failure of the Internet routing infrastructure.This paper describes the design and implementation of rcc, the router configuration checker, a tool that finds faults in BGP configurations using static analysis. rcc detects faults by checking constraints that are based on a high-level correctness specification. rcc detects two broad classes of faults: route validity faults, where routers may learn routes that do not correspond to usable paths, and path visibility faults, where routers may fail to learn routes for paths that exist in the network. rcc enables network operators to test and debug configurations before deploying them in an operational network, improving on the status quo where most faults are detected only during operation. rcc has been downloaded by more than sixty-five network operators to date, some of whom have shared their configurations with us. We analyze network-wide configurations from 17 different ASes to detect a wide variety of faults and use these findings to motivate improvements to the Internet routing infrastructure.
The Compartmentation of Acetyl-Coenzyme A Carboxylase in Plants (1995)

Although the biochemical pathways for fatty acid synthesis are more or less similar in plants and animals (Harwood, 1988), there is a major cell biological difference between these two groups of eukaryotes. In plants, the major site of fatty acid synthesis is the plastid, an organelle absent from the animal cell. Many aspects of plastid biology, including fatty acid synthesis, reflect the organelle's origins as a prokaryotic symbiont. The synthesis of fatty acids, such as palmitic acid, the prototype 16-carbon fatty acid, requires one molecule of acetyl-CoA and seven molecules of malonyl-CoA, which are added sequentially with the addition of two carbons to the growing fatty acid chain and the release of CO2 at each step. These reactions are catalyzed by fatty acid synthase, an enzyme complex known to exist in a prokaryotic and a eukaryotic form (Wakil et al., 1983; Harwood, 1988). The prokaryotic form (type II) of fatty acid synthase is found in plants. The synthase is composed of several dissociable proteins, whereas the eukaryotic form (type I) found in animals and yeasts is composed of one or two large multifunctional, nondissociable proteins. For either form, the synthesis requires malonyl-CoA, which is supplied by ACCase in the following reaction:
A novel antioxidant isolated from young green barley leaves (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel antioxidant isolated from young green barley leavesToshihiko. Osawa, Hirotaka. Katsuzaki, Yoshihide. Hagiwara, Hideaki. Hagiwara, and Takayuki. ShibamotoCite this: J. Agric. Food Chem. 1992, 40, 7, 1135–1138Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/jf00019a009https://doi.org/10.1021/jf00019a009research-articleACS PublicationsRequest reuse permissionsArticle Views429Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts