gebhart/patrepeval huggingface dataset:
QoS-Aware Joint Mode Selection and Channel Assignment for D2D Communications (2016)

Underlaying device-to-device (D2D) communications to a cellular network is considered as a key technique to improve spectral efficiency in 5G networks. For such D2D systems, mode selection and resource allocation have been widely utilized for managing interference. However, previous works allowed at most one D2D link to access the same channel, while mode selection and resource allocation are typically separately designed. In this paper, we jointly optimize the mode selection and channel assignment in a cellular network with underlaying D2D communications, where multiple D2D links may share the same channel. Meanwhile, the QoS requirements for both cellular and D2D links are guaranteed, in terms of Signal-to-Interference-plus-Noise Ratio (SINR). We first propose an optimal dynamic programming (DP) algorithm, which provides a much lower computation complexity compared to exhaustive search and serves as the performance bench mark. A bipartite graph based greedy algorithm is then proposed to achieve a polynomial time complexity. Simulation results will demonstrate the advantage of allowing each channel to be accessed by multiple D2D links in dense D2D networks, as well as, the effectiveness of the proposed algorithms.
Effects of hepatocyte growth factor overexpressed bone marrow‐derived mesenchymal stem cells on prevention from left ventricular remodelling and functional improvement in infarcted rat hearts (2012)

Bone marrow-derived mesenchymal stem cells (BM-MSCs ) transplantation has been reported to be a promising therapy for myocardial infarction (MI). However, low survival rate of BM-MSCs in infarcted heart is one of the major limitations for the perspective clinical application. In this study, we aimed to investigate the effect of hepatocyte growth factor (HGF) on left ventricular function improvement of HGF gene-modified BM-MSCs (HGF-MSCs) after its delivery into the infarcted rat hearts. BM-MSCs were isolated with fibroblast-like morphology and expressed CD44+CD29+CD90+/CD34-CD45-CD31-CD11a. After 5-azacytidine induction in vitro, 20%-30% of the cells were positively stained for desmin, cardiac-specific cardiac troponin I and connexin-43. Histological staining revealed that 2 weeks after MI is an optimal time point with decreased neutrophil infiltration and increased vascular number. Minimal infarct size and best haemodynamic analysis were also observed after cell injection at 2 weeks compared with that of 1 h, 1 week or 4 weeks. Echocardiogram confirmed that transplantation with HGF-MSCs significantly improved left ventricular function compared with other groups in rat MI models. MSCs and HGF-MSCslabelled with DAPI were detected 4 weeks after MI in the infarcted area. Decreased infarcted scar area and increased angiogenesis formation could be found in HGF-MSCs group than in other groups as demonstrated by hematoxylin and eosin (H&E) staining and factor VIII staining. These results indicate that HGF-MSCs transplantation could enhance the contractile function and attenuate left ventricular remodelling efficiently in rats with MI.
Graph Neural Networks with Feature and Structure Aware Random Walk (2021)

Graph Neural Networks (GNNs) have received increasing attention for representation learning in various machine learning tasks. However, most existing GNNs applying neighborhood aggregation usually perform poorly on the graph with heterophily where adjacent nodes belong to different classes. In this paper, we show that in typical heterphilous graphs, the edges may be directed, and whether to treat the edges as is or simply make them undirected greatly affects the performance of the GNN models. Furthermore, due to the limitation of heterophily, it is highly beneficial for the nodes to aggregate messages from similar nodes beyond local neighborhood.These motivate us to develop a model that adaptively learns the directionality of the graph, and exploits the underlying long-distance correlations between nodes. We first generalize the graph Laplacian to digraph based on the proposed Feature-Aware PageRank algorithm, which simultaneously considers the graph directionality and long-distance feature similarity between nodes. Then digraph Laplacian defines a graph propagation matrix that leads to a model called {\em DiglacianGCN}. Based on this, we further leverage the node proximity measured by commute times between nodes, in order to preserve the nodes' long-distance correlation on the topology level. Extensive experiments on ten datasets with different levels of homophily demonstrate the effectiveness of our method over existing solutions in the task of node classification.
Synthesis of Every Kinds of Peptide Fragments of Bradykinin (1969)

Synthesis of every kinds of peptide fragments of bradykinin and results of the biological activities of the synthetic bradykinin fragments on contracting effect of a guinea pig ileum, inframmatory activity on rat's hind paw and vasodilation on rat are described. So far as concerning with the contracting effect, the active site of bradykinin seems to be the phenylalanylserylprolylphenylalanine moiety. The inflammatory activity is fairy high as compared with that of bradykinin.
INFLUENCE OF FASTING AND CIMETIDINE ON THE RELATIONSHIP BETWEEN ULCEROGENIC AND ANTI‐INFLAMMATORY PROPERTIES OF INDOMETHACIN (1979)

1 Further studies have been carried out on the relationship between ulcerogenic and anti-inflammatory properties of indomethacin in the rat. 2 Fasting, which increases gastric and reduces intestinal lesions, enhances the anti-oedema properties of indomethacin. 3 The presence of intestinal lesions, greatly increases the anti-oedema properties of indomethacin through a mechanism(s) unrelated to the specific pharmacological properties of this drug. 4 Studies with cimetidine, have shown that the enhancement of anti-oedema effects produced by fasting are due to specific pharmacological properties of indomethacin rather than to non specific effects related to the presence of gastric ulcers. 5 The greater anti-inflammatory effects of indomethacin in fasted as compared to fed animals must be attributed to the greater amount of indomethacin available for tissue distribution rather than other mechanisms associated with free fatty acid mobilization. 6 In view of ineffectiveness in preventing intestinal lesions, the use of cimetidine for prevention or reduction of indomethacin-induced gastrointestinal disturbances in humans is contraindicated.
The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases (2006)

The association of the histone deacetylase (HDAC) inhibitor valproate (VPA) with atypical antipsychotics has become a frequent treatment strategy for schizophrenia and bipolar disorder. Because the VPA doses administered are elevated, one cannot assume that the benefits of the VPA plus antipsychotic treatment are exclusively related to the covalent modifications of nucleosomal histone tails. We compared the actions of N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]benzamide derivative (MS-275), which is a potent HDAC inhibitor in vitro, with the actions of VPA for their ability to (i) increase the acetylated status of brain nucleosomal histone tail domains and (ii) to regulate brain histone-RELN and histone-GAD(67) promoter interactions. MS-275 increases the content of acetylhistone 3 (Ac-H3) in the frontal cortex. Whereas this response peaks after a s.c. injection of 15 micromol/kg, the increase in Ac-H3 content in the hippocampus becomes significant only after an injection of 60 micromol/kg, suggesting that MS-275 is 30- to 100-fold more potent than VPA in increasing Ac-H3 in these brain regions. In contrast to VPA, MS-275, in doses up to 120 micromol/kg, fails to increase Ac-H3 content in the striatum. Chromatin immunoprecipitation shows that MS-275 increases Ac-H3-RELN and Ac-H3-GAD(67) promoter interaction in the frontal cortex. These results suggest that MS-275 is a potent brain region-selective HDAC inhibitor. It is likely that, in addition to MS-275, other benzamide derivatives, such as sulpiride, are brain-region selective inhibitors of HDACs. Hence, some benzamide derivatives may express a greater efficacy than VPA as an adjunctive to antipsychotics in the treatment of epigenetically induced psychiatric disorders.
Hereditary Diffuse Gastric Cancer Syndrome (2015)

This is the largest reported series of CDH1 mutation carriers, providing more precise estimates of age-associated risks of gastric and breast cancer that will improve counseling of unaffected carriers. In HDGC families lacking CDH1 mutations, testing of CTNNA1 and other tumor suppressor genes should be considered. Clinically defined HDGC families can harbor mutations in genes (ie, BRCA2) with different clinical ramifications from CDH1. Therefore, we propose that HDGC syndrome may be best defined by mutations in CDH1 and closely related genes, rather than through clinical criteria that capture families with heterogeneous susceptibility profiles.
Effects of the 5‐lipoxygenase activating protein inhibitor MK886 on voltage‐gated and Ca<sup>2+</sup>‐activated K<sup>+</sup> currents in rat arterial myocytes (1998)

1. The effects on the voltage-gated (IK) and Ca2+ activated (I(K,Ca)) K+ currents in rat arterial myocytes of the 5-lipoxygenase activating protein (FLAP) inhibitor MK886, and its inactive analogue L583,916 were evaluated. 2. In rat pulmonary arterial myocytes (RPAMs), MK886 caused a concentration-dependent reduction of the IK, with little obvious change in the kinetics of the current. Half maximal current block was observed at 75 nM MK886. 3. MK886 application led to a concentration-dependent increase in the amplitude of the TEA-sensitive I(K,Ca) current and single channel activity in RPAMs in whole cell and inside-out configurations, respectively. The threshold concentration for this effect was approximately 300 nM and a maximal 4-5 fold increase was observed at 10 microM MK886. MK886 also increased I(K,Ca) in rat mesenteric arterial myocytes (RMAMs). 4. L538,916, an analogue of MK886 which does not block FLAP, had no effect on either IK or I(K,Ca) at a concentration of 10 microM. 5. Leukotriene C4 (100 nM) had no effect on either IK or I(K,Ca) in RPAMs. MK886 produced its usual increase in I(K,Ca) and also blocked IK, in the presence of leukotriene C4. Similarly, leukotriene E4 (100 nM) did not alter the amplitude of IK. Also, the nonselective leukotriene receptor antagonist ICI 198,615 (3 microM) did not affect IK in RPAMs, and did not affect the response to MK886. 6. Arachidonic acid (10 microM) enhanced I(K,Ca) in both RPAMs and RMAMs. 7. The results show that MK886 markedly affects both IK and I(K,Ca) in a manner similar to that of arachidonic acid and independent of the endogenous production of leukotrienes. It is therefore possible that MK886, which is thought to compete with arachidonic acid for its binding to FLAP, may similarly occupy arachidonic acid binding sites on these K+ channels, and mimic its effects. Alternatively, MK886 might act via non-selective effects on other arachidonic acid metabolites which could modify K+ channel function.
New profile of cadaveric donors: what are the kidney donor limits? (1996)

The need for donor organs is increasing more rapidly than the number of organs available from present resources using today's techniques. While efforts to improve consent rates through education and various incentives should continue, and while recovery and utilization of kidneys from donors at the extremes of age can further improve, we believe that the greatest potential for future expansion of the donor resource lies in the non-heart-beating donor. The combination of effective in situ preservation and ex vivo pulsatile preservation allows donation to occur from uncontrolled asystolic donors and provides a mechanism for both evaluation and resuscitation of the recovered kidneys. This approach, if fully utilized, can double the number of kidneys available for transplantation.
1060nm FDML laser with centimeter coherence length and 1.67 MHz sweep rate for full eye length and retinal ultra-widefield OCT (2017)

We present a new design of a 1060nm Fourier Domain Mode Locked-Laser (FDML-Laser) that combines 1.67 MHz A-scan rate with a centimeter scale coherence length. The extended coherence length is achieved by synchronizing the cavity roundtrip time over the 75 nm sweep with a relative accuracy of 10 -7 . We will show that this requires careful combination of multiple fiber types in the cavity with a gradient heated chirped Fiber Bragg grating.
Asymmetric Hydroalkynylation of Norbornadienes Promoted by Chiral Iridium Catalysts (2012)

Across bonds: The first successful iridium-catalyzed asymmetric hydroalkynylation of nonpolar alkenes with good to excellent enantioselectivity is described (see scheme; cod = 1,5-cyclooctadiene, DCE = 1,2-dichloroethane). This catalytic system exhibits good functional group compatibility as NH(2), OH, Br, F, and SiMe(3) groups remain intact during the reaction.
Selective Leaching for the Preparation of Functional Porous Ceramics (2000)

Preparation of various porous ceramics by selective leaching method and their properties were summa rized and reviewed in this paper. Porous ceramics can be prepared utilizing variety of composite microtextures and crystal structures. Using interconnected microtexture in phase separated glasses formed by spinodal decomposition, porous glasses have been prepared and used for filter materials because they have crack free piercing pores in uniform size and good mechanical strength. Porous materials can be also prepared using nanocomposite microtextures formed by phase separation, crystallization and etc. In these porous materials, pores were formed by selective leaching of amorphous matrix. Since very fine nanocrystalline grains were spatially separated and exposed in the surface of pores, various interesting prop erties were obtained. Porous materials with unique porous properties can be prepared by selective leaching method from crystals with characteristic structures such as chain, layered and framework utilizing solubility difference in various components.
ChemInform Abstract: SYNTHESIS OF 4‐ARYLAZOISOXAZOLIUM SALTS (1976)

Abstract Synthesewege der bisher unbekannten 4‐Arylazo‐isoxazole (II), (V) bzw. (VII), die eine neue Klasse kationischer Farbstoffe darstellen, werden beschrieben.
Protection of Stem Cell-Derived Lymphocytes in a Primate AIDS Gene Therapy Model after In Vivo Selection (2009)

Here we demonstrate the ability to select protected HSC-derived lymphocytes in vivo in a clinically relevant nonhuman primate model of HIV/SHIV infection. This approach can now be evaluated in human clinical trials in AIDS lymphoma patients. In this patient setting, chemotherapy would not only kill malignant cells, but would also increase the number of MGMTP140K-expressing HIV-resistant cells. This approach should allow for high levels of HIV-protected cells in AIDS patients to evaluate AIDS gene therapy.
Toward an understanding of responses to methadone maintenance treatment organizational style (2005)

The organizational effectiveness of methadone maintenance treatment is qualitatively evaluated by analyzing levels of compliance and involvement with treatment programs for clients at three types of methadone clinics in the San Francisco Bay Area. Secondary analysis is used on longitudinal data collected from a project funded by the National Institute on Drug Abuse, “Injection Drug Users, Methadone Maintenance Treatment, and AIDS” (n = 233). This analysis rests on the theoretical model of clinics types differentiated by the clinic's style of control over clients. With a focus on the interaction between individuals and their institutional environments, the analysis compares three types of clinics: reformist, medical-model and libertarian. Reformist clinics exercise the most control over their clients and libertarians the least. Compliance with clinic rules is defined as changes in levels of drug use and involvement with clinic program is comprised of patterns of retention. While affiliation at all three clinic types reduces drug use, reasons for continued use vary substantially by clinic type. Variation is explained by a control balance approach to understanding responses to organizational type.
Toward Low-Latency and Ultra-Reliable Virtual Reality (2018)

VR is expected to be one of the killer applications in 5G networks. However, many technical bottlenecks and challenges need to be overcome to facilitate its wide adoption. In particular, VR requirements in terms of high throughput, low latency, and reliable communication call for innovative solutions and fundamental research cutting across several disciplines. In view of the above, this article discusses the challenges and enablers for ultra-reliable and low-latency VR. Furthermore, in an interactive VR gaming arcade case study, we show that a smart network design that leverages the use of mmWave communication, edge computing, and proactive caching can achieve the future vision of VR over wireless.
Ryanodine receptors FKBP12 and heart failure (2002)

RyR2 function is regulated by highly conserved signaling pathways that modulate excitation-contraction (EC) coupling. cAMP dependent protein kinase (PKA) phosphorylation of RyR2 plays an important role in regulating channel function in response to stress signaled by the sympathetic nervous system (the classic "fight or flight response") (1). PKA phosphorylation of RyR2 induces dissociation of the regulatory protein FKBP12.6 resulting in channels with increased sensitivity to Ca2+-induced Ca2+ release. Under normal physiological conditions (no cardiac damage) PKA phosphorylation of RyR2 is part of an integrated physiological response that leads to increased EC coupling gain and increased cardiac output. PKA-hyperphosphorylation of RyR2 in failing hearts is a maladaptive response that results in depletion of FKBP12.6 from the RyR2 macromolecular complex and defective channel function (pathologically increased sensitivity to Ca2+-induced Ca2+ release) that may cause depletion of SR Ca2+ and diastolic release of SR Ca2+ that can initiate delayed after depolarizations (DADs) that trigger ventricular arrhythmias (1). RyR2 mutations in patients with catecholaminergic induced sudden cardiac death provide further evidence linking the sympathetic nervous system, RyR2 and ventricular arrhythmias (2-4). The chronic hyperadrenergic state of heart failure is associated with defective Ca2+ signaling in part due to PKA hyperphosphorylation of RyR2.
Autonomous multi-species environmental gas sensing using drone-based Fourier-transform infrared spectroscopy (2019)

Unmanned aerial vehicles (UAVs)-or drones-present compelling new opportunities for airborne gas sensing in applications such as environmental monitoring, hazardous scene assessment, and facilities' inspection. Instrumenting a UAV for this purpose encounters trade-offs between sensor size, weight, power, and performance, which drives the adoption of lightweight electrochemical and photo-ionisation detectors. However, this occurs at the expense of speed, selectivity, sensitivity, accuracy, resolution, and traceability. Here, we report on the design and integration of a broadband Fourier-transform infrared spectrometer with an autonomous UAV, providing ro-vibrational spectroscopy throughout the molecular fingerprint region from 3 - 11 µm (3333 - 909 cm<sup>-1</sup>) and enabling rapid, quantitative aerial surveys of multiple species simultaneously with an estimated noise-limited performance of 18 ppm (propane). Bayesian interpolation of the acquired gas concentrations is shown to provide both localization of a point source with approximately one meter accuracy, and distribution mapping of a gas cloud, with accompanying uncertainty quantification.
Temporal response of extremely narrowband optical filters at 532 nm and their application in lidar systems (1996)

Summary form only given. This paper is concerned with the dynamic characteristics of narrow band optical filters operating at 532 nm in aerial lidar systems for underwater studies. In this paper two filters are reported a Faraday anomalous dispersion filter and a dichroism excited atomic line filter.
New bounds on the information rate of secret sharing schemes (1995)

/spl acute/A secret sharing scheme permits a secret to be shared among participants in such a way that only qualified subsets of participants can recover the secret, but any nonqualified subset has absolutely no information on the secret. We derive new limitations on the information rate of secret sharing schemes, that measures how much information is being distributed as shares as compared to the size of the secret key, and the average information rate, that is the ratio between the secret size and the arithmetic mean of the size of the shares. By applying the substitution technique, we are able to construct many new examples of access structures where the information rate is bounded away from 1. The substitution technique is a method used to obtain a new access structure by replacing a participant in a previous structure with a new access structure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
In vivo tumor immunotherapy by a bacterial superantigen. (1993)

We have investigated the in vivo efficacy of Staphylococcus aureus enterotoxin B (SEB) coupled to tumor-specific anti-idiotypic antibody in redirecting T cell effector activity to the growth inhibition of B lymphoma 38C13. Incubation of 38C13 lymphoma cells with syngeneic C3H/He splenic cells and SEB-anti-Id conjugate was associated with between 80 and 100% growth inhibition of the tumor cells. V beta 8+ T cells were integral for the SEB-anti-Id-induced tumor cell growth inhibition. Administration of SEB-anti-Id i.v. to mice previously inoculated with 38C13 lymphoma cells led to greater than 40% survival at 100 days compared to a mean survival of 21 days in control animals. When we compared this reagent with other targeting constructs--the anti-CD3-anti-Id and anti-TCR V beta 8-anti-Id--these more or less effectively prevented tumor growth. However, anti-CD3-anti-Id impaired almost the entire T cell response, whereas the effects of SEB-anti-Id or anti-V beta 8-anti-Id had effects limited to V beta 8+ T cells. Previous studies showed that in vivo administration of SEB caused a small change in V beta 8+ T cell numbers in contrast to anti-V beta 8 antibody, which depleted the entire population. These results together suggest that SEB-anti-tumor antibody conjugates represent a potentially powerful approach for better tumor immunotherapy.
Polymerization of vinyl chloride in the presence of acetaldehyde. Vinyl polymerization. LIII. (1961)

Abstract The polymerization of vinyl chloride initiated by azo‐bis‐isobutyronitrile was carried out in tetrahydrofuran at 50°C., in the presence of acetaldehyde. It was found that the rate of polymerization was proportional to the monomer concentration, and to the square root of the initiator concentration, and was inversely proportional to the acetaldehyde concentration. Degree of polymerization of polymers was obtained in the range of 50‐‐100 by viscometry, and from these values chain transfer constants to acetaldehyde, C A , and to the solvent, C S , were computed as 1.1 · 10 −‐2 , and 2.4 · 10 −‐3 , respectively. Polymers were insoluble in tetrahydrofuran, differing from the commercial polyvinyl chloride. The absorbance ration D 635 /D 692 was found in the range of 2.0‐‐2.7, and the ration increased with the increasing concentration of acetaldehyde in polymerization. Chemical and spectroscopic analyses were further carried out for the polymers; and from the results it was concluded that only one or two units of acetaldehyde were incorporated in polyvinyl chloride chain.