gebhart/patrepeval huggingface dataset:
Bisphosphonates for osteoporosis in people with cystic fibrosis (2001)

Intravenous pamidronate increases bone mineral density at axial sites in people with cystic fibrosis, although it can cause severe bone pain in patients not receiving corticosteroids. Additional studies in larger populations are needed to determine the effect on fracture rate and survival.
[Diagnostic and therapeutic problems in tumors of the bones of the hand]. (1979)

The diagnosis and treatment of tumors of the skeleton of the hand are reviewed. Benign enchondromas were found to be the most common. Primary osteogenetic sarcoma was rare as was malignant degeneration in initially benign tumors and in the bony manifestations of systemic disease such as neurofibromatosis or hyperparathyroidism. Tumors were more common in phalanges and metacarpals than in the carpus and showed their highest incidence in the 4th decade. Diagnosis was aided by angiography and bone-scanning. Some difficulties were encountered in pathological examination. Treatment involved curettage and cancellous grafting in small tumors, en bloc resection followed by osteosynthetic stabilisation in larger instances and radical ablation followed by chemotherapy in malignancy.
Addressing opioid overdose deaths: The vision for the HEALing communities study (2020)

The United States is facing two devastating public health crises- the opioid epidemic and the COVID-19 pandemic. Within this context, one of the most ambitious implementation studies in addiction research is moving forward. Launched in May 2019, the HEALing Communities Study (HCS) was developed by the National Institutes of Health (NIH) and the Substance Abuse and Mental Health Services Administration (SAMHSA) as part of the Helping to End Addiction Long-termSM Initiative (National Institutes of Health, 2020). The goal for this research was to reduce opioid overdose deaths by 40 % in three years by enhancing and integrating the delivery of multiple evidence-based practices (EBPs) with proven effectiveness in reducing opioid overdose deaths across health care, justice, and community settings. This paper describes the initial vision, goals, and objectives of this initiative; the impact of COVID-19; and the potential for knowledge to be generated from HCS at the intersection of an unrelenting epidemic of opioid misuse and overdoses and the ravishing COVID-19 pandemic.
Prolonged Urocortin 2 Administration in Experimental Heart Failure (2011)

Although acute administration of urocortin 2 has beneficial actions in heart failure, the integrated hemodynamic, hormonal, and renal effects of sustained urocortin 2 treatment in this disease have not been investigated. In the current study, we administered a 4-day infusion of a vehicle control (0.9% saline; n=6) or urocortin 2 (0.75 μg/kg per hour; n=6) to sheep with pacing-induced heart failure. Compared with time-matched controls, infusion of urocortin 2 produced rapid (30-minute) and persistent (4-day) improvements in cardiac contractility (day 4: control 905±73 versus urocortin 2 1424±158 mm Hg/s; P<0.001) and output (2.6±0.1 versus 3.8±0.3 L/min; P<0.001), together with reductions in left atrial pressure (28±1 versus 12±1 mm Hg; P<0.001) and peripheral resistance (30±2 versus 20±2 mm Hg/L per min; P<0.001). In contrast, urocortin 2-induced falls in mean arterial pressure were not established until the second day (day 4: 74±2 versus 72±2 mm Hg; P<0.05). Prolonged urocortin 2 administration was associated with sustained (days 0 to 4) declines in plasma renin activity (day 4: 1.33±0.27 versus 0.73±0.20 nmol/L per hour; P<0.001), aldosterone (970±383 versus 396±96 pmol/L; P<0.05), vasopressin (2.4±0.8 versus 1.3±0.1 pmol/L; P<0.05), endothelin 1 (7.2±0.7 versus 4.5±0.4 pmol/L; P<0.01), and atrial (269±27 versus 150±19 pmol/L; P<0.001) and B-type (65±9 versus 29±6 pmol/L; P<0.001) natriuretic peptides, as well as an acute transient rise in plasma cortisol (day 1: P<0.001). Chronic urocortin 2 also persistently augmented urinary sodium (day 4: 4-fold increase; P<0.001) and creatinine (1.4-fold; P<0.001) excretion and creatinine clearance (1.5-fold; P<0.01) compared with control. Food consumption was temporarily suppressed (P<0.05). In conclusion, 4-day urocortin 2 administration induces sustained improvements in hemodynamics and renal function, in association with inhibition of multiple vasoconstrictor/volume-retaining systems. These findings support the therapeutic potential for urocortin 2 in heart failure.
Studies of the expression of DNA repair related genes (1995)

This dissertation examines the biological functions and the regulation of expression of DNA ligase I by studying its expression under different conditions. The gene expression of DNA ligase I was induced two- to four-fold in S-phase lymphoblastoid cells but was decreased to 15% of control after administration of a DNA damaging agent, 4-nitroquinoline-1-oxide. When cells were induced into differentiation, the expression level of DNA ligase I was decreased to less than 15% of that of the control cells. When the gene of DNA ligase I was examined for tissue specific expression in adult rats, high levels of DNA ligase I mRNA were observed in testis (8-fold), intermediate levels in ovary and brain (4-fold), and low levels were found in intestine, spleen, and liver (1- to 2-fold). In confluent cells of normal skin fibroblasts, UV irradiation induced the gene expression of DNA ligase I at 24 and 48 h. The induction of DNA ligase I gene expression requires active p53 protein. Introducing a vector containing the wild type p53 protein in the cells caused an induction of the DNA ligase I protein 24 h after the treatment. Our results indicate that, in addition to the regulation by phosphorylation/dephosphorylation, cellular DNA ligase I activity can be regulated at the gene transcription level, and the p53 tumor suppresser is one of the transcription factors for the DNA ligase I gene. Also, our results suggest that DNA ligase I is involved in DNA repair as well as in DNA replication. Also, as an early attempt to clone the human homolog of the yeast CDC9 gene which has been shown to be involved in DNA replication, DNA repair, and DNA recombination, we have identified a human gene with mRNA of 1.7 kb. This dissertation studies the gene regulation and the possible biological functions of this new human gene by examining its expression at different stages of the cell cycle, during cell differentiation, and in cellular response to DNA damage. The new gene that we recently identified from human cells is highly expressed in brain and reproductive organs (BRE). This BRE gene encodes an mRNA of 1.7-1.9 kb, with an open reading frame of 1,149 bp, and gives rise to a deduced polypeptide of 383 amino acid residues. No extensive homology was found between BRE and sequences from the EMBL-Gene Banks. BRE showed tissue-specific expression in adult rats. The steady state mRNA levels were high in testis (5-6 fold), ovary and brain (3-4 fold) compared to the spleen level, but low in intestine and liver (1-2 fold). The expression of this gene is responsive to DNA damage and/or retinoic acid (RA) treatment. Treatment of fibroblast cells with UV irradiation and 4-nitroquinoline-1-oxide caused more than 90% and 50% decreases in BRE mRNA, respectively. Similar decreases in BRE expression were observed after treatment of the brain glioma cell line U-251 and the promyelocytic cell line HL-60 with retinoic acid. (Abstract shortened by UMI).
Time coding protocols for quantum key distribution (2004)

We propose quantum key distribution protocols based on coherent single-photon optical pulses with duration $T$ and with minimum time-frequency uncertainty. The pulses are sent with possible delays (e.g., 0, $T∕2$) that are used to code the information (e.g., bit 0, bit 1) and that are shorter than the pulse width. Therefore, the time detection of the photons may result in a ambiguity of the delay evaluation for a potential eavesdropper. The duration of the received pulses is controlled thanks to a contrast measurement using an interferometer. A quantum formalism is given, allowing us to model the transmission of the key and the consequences of a possible eavesdropping. Two protocols are proposed and discussed. The first one involves two states and is limited to channels with losses lower than 50%. The second one involves four states, which prevents the eavesdropper from exploiting the losses of the line. The security of each protocol is evaluated as a function of channel losses, quantum bit error rate, and contrast loss in the case of intercept-resend attacks. It is applied to situations where photocounters dark counts are the main limitation of the system. The resulting maximum propagation distance allowing secure communication is evaluated.
A novel phase unwrapping method based on network programming (1998)

Phase unwrapping is the reconstruction of a function on a grid given its values mod 2/spl pi/. Phase unwrapping is a key problem in all quantitative applications of synthetic aperture radar (SAR) interferometry, but also in other fields. A new phase unwrapping method, which is a different approach from existing techniques, is described and tested. The method starts from the fact that the phase differences of neighboring pixels can be estimated with a potential error that is an integer multiple of 2/spl pi/. This suggests the formulation of the phase unwrapping problem as a global minimization problem with integer variables. Recognizing the network structure underlying the problem makes for an efficient solution. In fact, it is possible to equate the phase unwrapping problem to the problem of finding the minimum cost flow on a network, for the solution of which there exist very efficient techniques. The tests performed on real and simulated interferometric SAR data confirm the validity of the approach.
The Effect of Prolonged Feeding of Antibiotics upon the Performance of Laying Hens (1953)

THE role of vitamin B12 as an essential factor in reproduction of poultry was established by Lillie, Olsen and Bird (1949) and Olcese and Couch (1950). Carver and McGinnis (1950) and Olcese, Couch and Lyman (1950) showed that hatchability was improved by a fermentation product now known to contain an antibiotic as well as vitamin B12. Olcese et al. (1950) reported that a definite peak of embryonic mortality occurred at the 17th day of incubation in eggs from hens fed a diet deficient in vitamin B12. Elam, Gee and Couch (1951a) reported that penicillin increased egg production and hatchability. Lillie and Bird (1952) reported that the presence of an antibiotic in the vitamin B12-aureomycin supplement appeared to have no influence on hatchability. Streptomycin and aureomycin did not improve hatchability when fed to hens receiving a sub-optimum amount of vitamin B12 (Petersen et al., 1952). Sunde et al. (1952) reported that …
Skill-based Mission Generation (2012)

Games often interweave a story and series of skill-based events into a complete sequence---a mission. An automated mission generator for skill-based games is one way to synthesize designer requirements with player differences to create missions tailored to each player. We argue for the need for predictive, data-driven player models that meet the requirements of: (1) predictive power, (2) accounting for temporal changes in player abilities, (3) accuracy in the face of little or missing player data, (4) efficiency with large sets of data, and (5) sufficiency for algorithmic generation. We present a tensor factorization approach to modeling and predicting player performance on skill-based tasks that meets the above requirements and a combinatorial optimization approach to mission generation to interweave an author's preferred story structures and an author's preferred player performance over a mission---a kind of difficulty curve---with modeled player performance.
HOT-PRESSED LEAD ZIRCONATE-LEAD TITANATE CERAMICS CONTAINING BISMUTH (1964)

A new species of Mycetophilidae, Cordyla australica sp. n., is described from continental Australia and Tasmania, representing the first Cordyla record in the region. A detailed description of its morphology with illustrations of male and female terminalia and a map of the collecting localities are provided. According to the structure of male terminalia, Cordyla australica sp. n. belongs to the Cordyla murina species-group that has 13 species worldwide. Within the group Cordyla australica sp. n. resembles Cordyla murina but has a unique outline of the hypoproct and medial branch of the gonostylus. The observed distributional pattern is restricted to the rainforest of eastern Australia and Tasmania.
Current efficiency in organic light-emitting diodes with a hole-injection layer (2008)

We have systematically investigated the effect of layer structures on the current efficiency of prototypical hole-injection layer (HIL)/hole-transport layer (HTL)/electron-transport layer (ETL) organic light-emitting diodes based on 4,4′,4″-tris[N-(3-methylphenyl)-N-phenylamino]triphenylamine (MTDATA) as the HIL, 4,4′-bis[N-(1-naphthyl)-N-phenylamino]biphenyl (NPB) as the HTL, and tris(8-quinolinolato)aluminum (Alq) as the ETL. With bilayer devices, the current efficiency is limited by exciplex emissions in the case of MTDATA/Alq and quenching of Alq emissions by NPB+ radical cations in NPB/Alq. The improved current efficiency in trilayer MTDATA/NPB/Alq devices can be attributed to a reduction in NPB+ radical cations at the NPB/Alq interface and a strong electric field in the NPB layer.
Secondary Slow Trapping - A New Moisture Induced Instability Phenomenon in Scaled Cmos Devices (1982)

A new instability phenomenon in scaled CMOS devices is presented. Threshold voltage shifts caused by this phenomenon are observed in negative gate bias conditions. The shifts are depend on test temperatures, bias conditions applied to the device and channel lengths of devices. It is found that the activation energy of acceleration factor in this shift is between 1.0eV and 1.2eV. As a result of an analysis, this phenomenon may be found to be caused by moisture initially involved in a phosphosilicate glass passivation layer.
Synthesis and selective activity of cholinergic agents with rigid skeletons. II. (1981)

Three types of compound, quinuclidine-3-spiro-2'-dioxolane (A), piperidine-4-spiro-2'-dioxolane (B), and piperidine-4-spiro-2'-(4'-oxodioxolane) (C) and their methiodides were synthesized. The cholinomimetic activities of these compounds were examined to investigate the relationship between the activities of these compounds, which have rigid skeletons, and those of known muscarinic agents.
Design optimization of ARROW-type diode lasers (1992)

Antiresonant reflecting optical wavelength (ARROW)-type diode lasers have been optimized for high-power, single-spatial-mode operation. Calculated modal behavior predicts strong intermodal discrimination with low loss for the fundamental ARROW mode. Single-lobe far-field operation is obtained only when the high-index reflecting (antiresonant) cladding layers correspond to an optical thickness of lambda /sub 1/ (m+3/4), where lambda is the lateral (projected) wavelength of the leaky wave in the high-index layers, and m is an integer (m=0, 1,. . .). Experimental results include stable, single-spatial mode operation to 500-mW peak pulsed power and 300-mW CW power at an emission wavelength of 0.98 mu m.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Wide ferroelectrics (1980)

Abstract Halide ferroelectrics which form larger families of related substances are classified as binary compounds of the HCl group, ABX3, ABX4, A2BX4 compounds and as halides containing organic groups. The importance of crystal engineering within the individual groups is briefly discussed and some possible future trends are shown.
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable <i>O</i>-Phosphocholine-<i>N</i>-docosahexaenoyl-<scp>l</scp>-serine siRNA Conjugate in Mouse Brain (2017)

Ligand-conjugated siRNAs have the potential to achieve targeted delivery and efficient silencing in neurons following local administration in the central nervous system (CNS). We recently described the activity and safety profile of a docosahexaenoic acid (DHA)-conjugated, hydrophobic siRNA (DHA-hsiRNA) targeting Huntingtin (Htt) mRNA in mouse brain. Here, we report the synthesis of an amide-modified, phosphocholine-containing DHA-hsiRNA conjugate (PC-DHA-hsiRNA), which closely resembles the endogenously esterified biological structure of DHA. We hypothesized that this modification may enhance neuronal delivery in vivo. We demonstrate that PC-DHA-hsiRNA silences Htt in mouse primary cortical neurons and astrocytes. After intrastriatal delivery, Htt-targeting PC-DHA-hsiRNA induces ∼80% mRNA silencing and 71% protein silencing after 1 week. However, PC-DHA-hsiRNA did not substantially outperform DHA-hsiRNA under the conditions tested. Moreover, at the highest locally administered dose (4 nmol, 50 μg), we observe evidence of PC-DHA-hsiRNA-mediated reactive astrogliosis. Lipophilic ligand conjugation enables siRNA delivery to neural tissues, but rational design of functional, nontoxic siRNA conjugates for CNS delivery remains challenging.
Conventional Hot Extrusion (2005)

Abstract Hot extrusion is a process in which wrought parts are formed by forcing a heated billet through a shaped die opening. This article discusses nonlubricated and lubricated hot extrusion. The two nonlubricated hot extrusion methods are forward or direct extrusion and backward or indirect extrusion. The article illustrates the significance of extrusion speeds and temperatures in hot extrusion. It describes the basic types of presses used in the hot extrusion of metals. The article provides information on the characterization of extruded shapes and explains the operating parameters, including extrusion velocity, amount of pressure required, and type of lubricant, for successful and efficient hot extrusion. The article concludes with a discussion on applications and design methodology that provides insight into CAD/CAM of extrusion dies.
A Validation Testsuite for OpenACC 1.0 (2014)

Directive-based programming models provide high-level of abstraction thus hiding complex low-level details of the underlying hardware from the programmer. One such model is OpenACC that is also a portable programming model allowing programmers to write applications that offload portions of work from a host CPU to an attached accelerator (GPU or a similar device). The model is gaining popularity and being used for accelerating many types of applications, ranging from molecular dynamics codes to particle physics models. It is critical to evaluate the correctness of the OpenACC implementations and determine its conformance to the specification. In this paper, we present a robust and scalable testing infrastructure that serves this purpose. We worked very closely with three main vendors that offer compiler support for OpenACC and assisted them in identifying and resolving compiler bugs helping them improve the quality of their compilers. The testsuite also aims to identify and resolve ambiguities within the OpenACC specification. This testsuite has been integrated into the harness infrastructure of the TITAN machine at Oak Ridge National Lab and is being used for production. The testsuite consists of test cases for all the directives and clauses of OpenACC, both for C and Fortran languages. The testsuite discussed in this paper focuses on the OpenACC 1.0 feature set. The framework of the testsuite is robust enough to create test cases for 2.0 and future releases. This work is in progress.
Interference Awareness in IEEE 802.11 Mesh Networks (2006)

With current amendments, transmission rates of 54 Mb/s and more with IEEE 802.11 WLANs become possible. On the one hand, this allows the end user to change from wired to wirless infrastructure in even more application scenarios, on the other hand the sensible transmission modes reduce the maximum distance between the mobile Station (STA) and the Access Point (AP) to few meters in indoor environments. To extend the transmission range transparently, relay APs can form a mesh network to provide wireless connection over large areas. The Mesh Network Alliance (MNA) has presented an amendment to the IEEE Task Group s with the aim of enhancing the legacy 802.11 medium access protocol to enable efficient mesh operation. In this work we give a short overview of MNA and introduce a possible extension to enhance its frequency reuse in scenarios of mutual interference. The possible throughput of a mesh build upon legacy 802.11, MNA and the enhanced MNA are compared by simulation using theWARP2 simulation engine.
Rechargeable Li<sub>2</sub>O<sub>2</sub> Electrode for Lithium Batteries. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Remedian: A Robust Averaging Method for Large Data Sets (1990)

Abstract It is often assumed that to compute a robust estimator on n data values one needs at least n storage elements (contrary to the sample average, that may be calculated with an updating mechanism). This is one of the main reasons why robust estimators are seldom used for large data sets and why they are not included in most statistical packages. We introduce a new estimator that takes up little storage space, investigate its statistical properties, and provide an example on real-time curve “averaging” in a medical context. The remedian with base b proceeds by computing medians of groups of b observations, and then medians of these medians, until only a single estimate remains. This method merely needs k arrays of size b (where n = bk ), so the total storage is O(log n) for fixed b or, alternatively, O(nl/k ) for fixed k. Its storage economy makes it useful for robust estimation in large data bases, for real-time engineering applications in which the data themselves are not stored, and for resistant “averaging” of curves or images. The method is equivariant for monotone transformations. Optimal choices of b with respect to storage and finite-sample breakdown are derived. The remedian is shown to be a consistent estimator of the population median, and it converges at a nonstandard rate to a median-stable distribution.