gebhart/patrepeval huggingface dataset:
Event-Driven Data Integration for Personal Health Monitoring (2009)

The emergence of biomedical wireless sensors, the wide spread use of smartphones, and advanced data stream mining techniques have enabled a new generation of personal health monitoring systems. These health monitoring systems are mostly stand-alone and are not yet integrated with existing e-Health systems, which could seriously limit their large scale deployment. In this paper, we propose an architecture for data integration within an electronic health care network based on extending the traditional SOA approach with support for complex event processing and context awareness. This architecture also facilitates integrated business performance management against quality of care targets. A detailed health monitoring scenario for the care of cardiac patients is used to illustrate system requirements and to validate the proposed architecture. The expected benefits of our approach include a higher quality of care, reduced costs for health service providers and a higher quality of life for the patients.
Plant AP2/ERF transcription factors (2003)

Transcription factors (TFs) play important roles in plant development and its response to the biotic and abiotic stresses. AP2/ERF transcription factors family is unique to plants and a conserved AP2/ERF domain of about 60 amino acids characterized these transcription factors. AP2/ERF genes have been shown to regulate developmental processes and the response of plants to various types of biotic and environmental stress. Here, we summarize the current knowledge of AP2/ERF plant transcription factor family.
Usos y ventajas de los rayos X para el diagnóstico. (1917)

Primeras radiografias dentarias. Evoluciones con las bobinas y tubos. Perfeccion actual de los aparatos. La radiografia en la piorrea. Uso sistematico de la radiografia en trabajos de corona y puente. Posicion del paciente al tomar la radiografia. Placas y peliculas. El porta peliculas de autor. Importancia de la interpretacion correcta. Radiografias estereocopicas.
Dark Exposure Extends the Integration Window for Spike-Timing-Dependent Plasticity (2012)

Metaplasticity, the adaptive changes of long-term potentiation (LTP) and long-term depression (LTD) in response to fluctuations in neural activity is well documented in visual cortex, where dark rearing shifts the frequency threshold for the induction of LTP and LTD. Here we studied metaplasticity affecting spike-timing-dependent plasticity, in which the polarity of plasticity is determined not by the stimulation frequency, but by the temporal relationship between near-coincidental presynaptic and postsynaptic firing. We found that in mouse visual cortex the same regime of deprivation that restricts the frequency range for inducing rate-dependent LTD extends the integration window for inducing timing-dependent LTD, enabling LTD induction with random presynaptic and postsynaptic firing. Notably, the underlying mechanism for the changes in both rate-dependent and time-dependent LTD appears to be an increase of NR2b-containing NMDAR at the synapse. Thus, the rules of metaplasticity might manifest in opposite directions, depending on the plasticity-induction paradigms.
A disease-specific activity index for Wegener's granulomatosis: Modification of the Birmingham Vasculitis Activity Score (2001)

The BVAS/WG is a valid, disease-specific activity index for WG. Tested in simulation exercises and in actual patients, the BVAS/WG correlates well with the PGA, is sensitive to change, and has good inter- and intraobserver reliability. The INSSYS will use the BVAS/WG to assess the primary outcome in a phase II/III trial of etanercept in WG.
Levoglucosenone: A Chiral Building Block with a New Perspective (2001)

Levoglucosenone, a chiral bicyclic enone with excellent reactivity and functionality, is a convenient precursor for the synthesis of many attractive templates of complex, natural products and is attracting steady interest due to its rigidity and stereoselective functionalization in many synthetic organic methodologies.
Spectral energy of the first heart sound in acute myocardial ischemia. A correlation with electrocardiographic, hemodynamic, and wall motion abnormalities. (1978)

First heart sound (S1) energy spectra in isovolumic systole, hemodynamics, and angiographic left ventricular wall motion (LVWM) at rest and with atrial pacing were compared in 27 patients who underwent diagnostic cardiac catheterization and angiography because of chest pain. Eighteen patients were found to have coronary artery disease (CAD) and nine patients, normal coronary arteries. Eleven of the 18 CAD patients (61%) had a mean reduction in the spectral energy of S1 of 6.5 +/- 1.4 (SEM) dB below control (-52%), during interruption of ischemic stress of rapid atrial pacing, compared to only one of nine patients without CAD (P less than 0.05). Only five CAD patients (28%) had an abnormal rise (greater than or equal to 5 mm) in left ventricular end-diastolic pressure (LVEDP) either during or upon interruption of pacing, and six (33%) had ischemic ST-segment depression greater than or equal to mv in the ECG. Similarly two patients free of CAD (22%) had an abnormal increase in LVEDP, and none had ECG evidence of ischemia. Seventeen CAD patients (94%) had segmental LVWM abnormalities at rest or with interruption of pacing, while three patients with normal coronary arteries (33%) had abnormal angiographic LVWM (P less than 0.01). Thus, reduction is S1 spectral energy is a common accompaniment of myocardial ischemia. In the present study, it was more frequently observed than abnormalities in either the ECG or LVEDP, but was not was consistently seen as segmental left ventricular wall motion abnormalities.
InGaAsP/InP Laser Diodes Mounted on Semi-Insulating SiC Ceramics (1983)

Semi-insulating SiC ceramics is proposed as a new material for InGaAsP/InP laser diode heatsinks. It is featured by high theraml conductivity (2.7 W/cm deg) and high electrical resistivity (4×10 13 Ohm cm). The expansion coefficient of the material is 3.7×10 -6 deg -1 , which is very close to that of InP. The electrical and thermal characteristics, and reliability of InGaAsP/InP buried heterostructure (BH) lasers mounted on SiC heatsinks are also discussed. Stable modulated operation of up to 1 GHz, a maximum temperature for cw lasing of up to 100°C, and an expected median lifetime of 3×10 4 hrs at 60°C have been demonstrated for these lasers.
Exploration of the Structure and Recognition of a G-quadruplex in the her2 Proto-oncogene Promoter and Its Transcriptional Regulation (2019)

G-quadruplexes in oncogene promoters provide putative targets for transcriptional regulation. The structure of a putative G-quadruplex sequence (S1: GGAGAAGGAGGAGGTGGAGGAGGAGGG) in potassium solution in the her2 promoter has been resolved mainly through nuclear magnetic resonance (NMR) spectroscopy. By application of various NMR spectra, we proved the formation of a four-layer G-quadruplex composing of two G-tetrads and two G/A-mixed planes with a four-residues loop (A3-G4-A5-A6). Further evidence from a luciferase reporter assay, Q-RT-PCR and Western blotting indicates that S1 G-quadruplex formation can repress her2 promoter activity, and a selected G-quadruplex ligand cβ can enhance the repression by down regulating her2 transcription and expression. These findings provide a G-quadruplex target and perspective implications in her2 transcriptional regulation.
Integrated safety and reliability analysis methods for aircraft system development using multi-domain object-oriented models (2016)

Safety and reliability are essential in commercial air transport. Therefore, safety assessment is an inherent part of the aircraft systems development process. Operational reliability has to be considered for economic reasons. Most of the state-of-the-art methods for safety and reliability analysis employ a binary representation of the system. One of these is fault tree analysis (FTA), a manual method that is still common today. Conducting safety or reliability analysis by means of FTA involves considerable effort. In addition, because of the binary, non-physical approach, such analysis tools remain uncoupled to other engineering tools. Nowadays, a multi-domain object-oriented approach has become the state-of-the-art in physical modelling and simulation. Such an approach enables an intuitive method of modelling, in which the objects, their boundaries and interconnections correspond to real existing components. This thesis contributes to the field of model-based methods for system safety and reliability analysis. Here, the most important innovation is that the proposed methods suit multi-domain object-oriented modelling based on differential-algebraic equations. Search techniques and algorithms founded on graph theory were devised in order to minimise the computing effort for conducting an analysis. The proposed methods enable establishing multi-disciplinary engineering tools for the conceptual design of fault-tolerant systems. The aim is improvement of system development and safety assessment processes.
Confiabilidad y validez de un instrumento que mide las expectativas en torno a la globalización (2018)

El objetivo del presente trabajo es establecer un modelo para el estudio del dialogo entre los actores economicos, politicos y sociales en general y la investigacion de la aceptacion y la utilidad de las alianzas estrategicas entre multinacionales y pymes en el mercado local. 
Grosso modo, las expectativas en torno a la globalizacion refieren a las consecuencias esperadas ante las alianzas estrategicas entre multinacionales y pymes en torno al desarrollo local, pero su importancia radica en la exploracion de climas organizacionales propicios para las redes, gestiones, producciones y transferencia de innovaciones orientadas al posicionamiento de marcas en el mercado local y su consolidacion en el concierto internacional
Auto-calibration for sensor gain/phase perturbations via exploitation of antenna arrays' symmetry property (2002)

This paper proposes a novel auto-calibration technique for pre-calibrated sensor gain/phase (complex gain) perturbations by joint estimation. The technique exploits the symmetry property of antenna arrays, and is practically realizable. An iterative formula together with an alternating iterative procedure is presented to estimate the sensor complex gains. The uniqueness condition is investigated and the Cramer-Rao lower bound for DOA estimation is given. Simulation results confirm the effectiveness of the technique.
Power Consumption Modeling of Discontinuous Reception for Cellular Machine Type Communications (2019)

Machine-type communication (MTC) is an emerging communication trend where intelligent machines are capable of communicating with each other without human intervention. Mobile cellular networks, with their wide range, high data rates, and continuously decreasing costs, offer a good infrastructure for implementing them. However, power consumption is a great issue, which has recently been addressed by 3GPP (3rd Generation Partnership Project) by defining power-saving mechanisms. In this paper, we address the problem of modeling these power-saving mechanisms. Currently existing modeling schemes do not consider the full range of states in the discontinuous reception (DRX) mechanism in LTE-A networks. We propose a semi-Markov based analytical model, which closes this gap and shows very good results in terms of predicting performance evaluation metrics, such as the power-saving factor and wake-up latency of MTC devices compared to simulation experiments. Furthermore, we offer an evaluation of the DRX parameters and their impact on power consumption of MTC devices.
Bioengineered Human Arginase I with Enhanced Activity and Stability Controls Hepatocellular and Pancreatic Carcinoma Xenografts (2011)

Hepatocellular carcinoma (HCC) and pancreatic carcinoma (PC) cells often have inherent urea cycle defects rendering them auxotrophic for the amino acid l-arginine (l-arg). Most HCC and PC require extracellular sources of l-arg and undergo cell cycle arrest and apoptosis when l-arg is restricted. Systemic, enzyme-mediated depletion of l-arg has been investigated in mouse models and human trials. Non-human enzymes elicit neutralizing antibodies, whereas human arginases display poor pharmacological properties in serum. Co(2+) substitution of the Mn(2+) metal cofactor in human arginase I (Co-hArgI) was shown to confer more than 10-fold higher catalytic activity (k(cat)/K(m)) and 5-fold greater stability. We hypothesized that the Co-hArgI enzyme would decrease tumor burden by systemic elimination of l-arg in a murine model. Co-hArgI was conjugated to 5-kDa PEG (Co-hArgI-PEG) to enhance circulation persistence. It was used as monotherapy for HCC and PC in vitro and in vivo murine xenografts. The mechanism of cell death was also investigated. Weekly treatment of 8 mg/kg Co-hArgI-PEG effectively controlled human HepG2 (HCC) and Panc-1 (PC) tumor xenografts (P = .001 and P = .03, respectively). Both cell lines underwent apoptosis in vitro with significant increased expression of activated caspase-3 (P < .001). Furthermore, there was evidence of autophagy in vitro and in vivo. We have demonstrated that Co-hArgI-PEG is effective at controlling two types of l-arg-dependent carcinomas. Being a nonessential amino acid, arginine deprivation therapy through Co-hArgI-PEG holds promise as a new therapy in the treatment of HCC and PC.
A multi-purpose cadastre prototype on the web (2000)

The Multi-Purpose Cadastre concept has been discussed over the last three decades. The concept, although idealistic when conceived, is still regarded as visionary in addressing the inherent limitations of most modern geo-spatial systems, especially cadastral systems worldwide. The concept is being used to better disseminate and utilise the increasingly large amount of data contained in many of the geo-spatial databases developed over the last few years. The utilisation of the World Wide Web has allowed these geo-spatial systems to evolve into online ‘virtual ’ systems that are accessible by most people with the appropriate tools (the computers and telephone lines). This thesis analysed the growing development of these online systems. It describes a review of online cadastral systems that revealed the similarities in moving towards the future vision of cadastral systems of the 21st century, as highlighted by the International Federation of Surveyors document, Cadastre 2014. The rapidly growing volume of geo-spatial data, which has been attributed by technologies such as remote sensing and Global Positioning Systems, are impacting on the way societies
Role of power jitter induced by interchannel interactions in dispersion-managed lines (2002)

Collision induced power jitter is examined in dispersion-managed wavelength-division-multiplexed transmission systems. The power jitter causes a serious problem for a singly-periodic dispersion managed line having almost zero average dispersion, which can be reduced by applying doubly-periodic dispersion management.
Chemotherapy and Cognitive Function in Breast Cancer Patients: The So-Called Chemo Brain (2015)

Self-perceived problems of cognitive functioning after treatment for early-stage breast cancer have the potential to substantially affect the lives of patients. In the past two decades, neuropsychological studies have accumulated evidence of corresponding cognitive deficits that have mostly been attributed to neurotoxic effects of chemotherapy. Nevertheless, observations of impaired cognitive functioning already before the start of adjuvant or neoadjuvant chemotherapy question the singular role of chemotherapy for the causation of these deficits. The divergence between mostly subtle neuropsychological deficits and often dramatic subjective cognitive complaints as well as the lack of association between both in the majority of studies present an unsolved puzzle. Recent investigations that include brain imaging have begun to yield tentative answers in this regard. The present review aims at briefly summarizing and integrating the current evidence from clinical studies for purposes of patient counseling.
A precision autozeroing sample and hold integrated circuit (1980)

A precision sample and hold integrated circuit with autozeroing of all DC errors is described. Experimental data have shown that it provides the accuracy necessary for use in 12 bit data acquisition systems. Application of noise-optimized silicon gate FET devices for the input circuitry of amplifiers which buffer the hold capacitor results in a low droop rate and allows the sample/hold to operate without external components. Common mode rejection is optimized through implementation of a modified current source offering extremely high output impedance at high operating currents. The device includes all digital control and switching circuitry.
The influence of left ventricular late diastolic filling on the A wave of the left ventricular pressure trace. (1979)

To study the influence of left ventricular (LV) late diastolic filling on the A wave of the LV pressure, simultaneously recorded echocardiographic LV dimensions and high-fidelity LV pressure measurements were taken in 24 patients. Group 1 comprised eight patients without LV hypertrophy (LVH) and LV end-diastolic pressure (LVEDP) less than or equal to 13 mm Hg. Group 2 comprised 16 patients with LVH secondary to aortic stenosis, idiopathic hypertrophic subaortic stenosis, or hypertension and increased LVEDP. Patients in group 2 had significantly thicker left ventricles, decreased mitral E-to-F slopes, and larger A waves in the LV pressure curve. On the basis of end-diastolic chamber stiffness, we divided group 2 into two populations: 12 patients (group 2A) with end-diastolic chamber stiffness similar to that in group 1, and four patients (group 2B) with markedly elevated end-diastolic chamber stiffness. Patients in group 2A had a larger atrial contribution to LV filling than those with markedly abnormal stiffness (group 2B). Therefore, in LVH an increased A wave in the LV pressure may be related to either elevated end-diastolic chamber stiffness or augmented left atrial volume transport.
Signal transduction by reactive oxygen species (2011)

Although historically viewed as purely harmful, recent evidence suggests that reactive oxygen species (ROS) function as important physiological regulators of intracellular signaling pathways. The specific effects of ROS are modulated in large part through the covalent modification of specific cysteine residues found within redox-sensitive target proteins. Oxidation of these specific and reactive cysteine residues in turn can lead to the reversible modification of enzymatic activity. Emerging evidence suggests that ROS regulate diverse physiological parameters ranging from the response to growth factor stimulation to the generation of the inflammatory response, and that dysregulated ROS signaling may contribute to a host of human diseases.
Ultrasound-driven Megahertz Faraday Waves for Generation of Monodisperse Micro Droplets and Applications (2015)

Our theoretical findings on instability of Faraday waves at megahertz (MHz) drive frequency and realization of silicon-based MHz multiple-Fourier horn ultrasonic nozzles (MFHUNs) together have enabled generation of mono-disperse droplets of controllable diameter (2.5-6.0 μm) at very low electrical drive power (<0.5 Watt). The resulting battery-run clogging-free droplet generator has imminent application to pulmonary (inhalation) drug delivery and other potential applications. Here an update of advances on analysis and design of the MHz MFHUNs and the underlying physical mechanism for generation of mono-disperse micro droplets, and the nebulizer platform for application to detoxification of cyanide poisoning are presented.
The Violent Lights of Capitalism: The Artificiality of Japan in Giants and Toys (2018)

Japanese New Wave, similar to new wave movements that appeared after the second world war, was a collision of both a cultural and artistic movement. Japan’s new wave movement represented a new youth that rejected old traditions and struggled with state power. Among the hundreds of films identified as part of this filmic era, Giants and Toys was, and still remains to be, one of the flag bearers for Japanese New Wave. This paper provides a close analysis of the showdown scene between the two main characters Goda and Nishi and engages in discussion about how this relates to the film and Japan as a whole. A stark look at the rapidly growing centrality of capitalism in postwar Japan, this particular scene in Giants and Toys confronts viewers’ with several notes in its mise-en-scéne, cinematography, choreography, and dialogue that explicitly illustrate director Yasuzo Masumuro’s own belief about the state of Japan. This paper reveals through this analysis that it is Masumuro’s belief that it is impossible for Japan to possess autonomous subjectivity, doomed by its act of masking its traditions with Western, and specifically American, ways.
Evaluating Author and User Experience for an Audio-Haptic System for Annotation of Physical Models (2017)

We describe three usability studies involving a prototype system for creation and haptic exploration of labeled locations on 3D objects. The system uses a computer, webcam, and fiducial markers to associate a physical 3D object in the camera's view with a predefined digital map of labeled locations ("hotspots"), and to do real-time finger tracking, allowing a blind or visually impaired user to explore the object and hear individual labels spoken as each hotspot is touched. This paper describes: (a) a formative study with blind users exploring pre-annotated objects to assess system usability and accuracy; (b) a focus group of blind participants who used the system and, through structured and unstructured discussion, provided feedback on its practicality, possible applications, and real-world potential; and (c) a formative study in which a sighted adult used the system to add labels to on-screen images of objects, demonstrating the practicality of remote annotation of 3D models. These studies and related literature suggest potential for future iterations of the system to benefit blind and visually impaired users in educational, professional, and recreational contexts.
The biologically active constituents of Ganoderma lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes. (1985)

The MeOH extract of Ganoderma lucidum has an inhibitory action on histamine release from rat mast cells. From the physiologically active fraction of the extract, along with the known triterpenes ganoderic acids A and B, two new triterpenes were isolated and named ganoderic acids C and D. The structures of ganoderic acids C and D were determined to be 3β, 7β, 15α-trihydroxy-11, 23-dioxo-5α-lanost-8-en-26-oic acid and 7β-hydroxy-3, 11, 15, 23-tetraoxo-5α-lanost-8-en-26-oic acid respectively. Ganoderic acids C and D were shown to inhibit histamine release from rat mast cells. Quantitative analysis of these triterpenes was performed for the purpose of crude drug quality control.
A comparison of 3,4,6a,7,10,10a-hexahydro-7,10-epoxypyrimido[2,1-<i>a</i>]isoindol-6(2<i>H</i>)-one and 2-(2-aminoethyl)-3a,4,7,7a-tetrahydro-1<i>H</i>-4,7-epoxyisoindole-1,3(2<i>H</i>)-dione: structural and reactivity differences of two homologous tricyclic imides (2013)

The crystal structures of 3,4,6a,7,10,10a-hexahydro-7,10-epoxypyrimido[2,1-a]isoindol-6(2H)-one, C11H12N2O2, and 2-(2-aminoethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione, C10H12N2O3, two tricyclic imides, show one and two molecules in the asymmetric unit, respectively. Intermolecular hydrogen-bonding interactions are observed in both compounds.