gebhart/patrepeval huggingface dataset:
Hagfish slime ecomechanics: testing the gill-clogging hypothesis (2006)

Hagfish are able to produce substantial amounts of slime when harassed, but the precise ecological function of the slime is unclear. One possibility is that the slime acts as a defence against gill-breathing predators, whose gills may become entangled with the slime's mixture of mucins and fibrous threads during an attack. We previously demonstrated that hagfish slime does not bind water tightly, but instead behaves like a fine sieve that slows water down via viscous entrainment. These properties are consistent with the gill-clogging hypothesis, which we tested here by quantifying the effects of hagfish slime on water flow through an artificial gill model and real fish gills. Our results indicate that the slime is capable of clogging gills and increasing the resistance that they present to the flow of water. We also characterized the behaviour of slime release from live hagfish and the effect of convective mixing on the formation of slime in vitro. Our observations show that exudate is locally released from the slime glands as a coherent jet and that hagfish do not appear to use their slime as a protective envelope. We found that convective mixing between the exudate and seawater is necessary for proper slime formation, but excessive mixing leads to the slime's collapse. We suggest that the loose binding of water by the slime may be an optimal solution to the problem of delivering an expanding jet of flow-inhibiting material to the gills of would-be predators.
Epstein-Barr virus (EBV) glycoprotein gp350 expressed on transfected cells resistant to natural killer cell activity serves as a target antigen for EBV-specific antibody-dependent cellular cytotoxicity (1991)

Cell surface-associated viral glycoproteins are thought to play a major role as target antigens in cellular cytotoxicity and antiviral immunosurveillance. One such glycoprotein is the Epstein-Barr virus (EBV)-encoded glycoprotein 350 (gp350), which is expressed on both virion envelope and EBV producer cells and carries the virus attachment protein moiety. Although it is known that some antibodies to gp350 can neutralize the virus, the role of this glycoprotein in EBV-specific cellular cytotoxicity is not yet clear. We describe here a study in which we successfully used a new approach to demonstrate that gp350 is a target antigen for EBV-specific antibody-dependent cellular cytotoxicity (ADCC). Transfection of gp350-negative cells resistant to natural killer (NK) cell activity (i.e., Raji) with a recombinant vector (pZIP-MA) containing the gene encoding the EBV-gp350 and the neomycin resistance gene enabled us to isolate cell clones with a stable and strong expression of gp350 on their surface membranes. ADCC determined by using two clones clearly demonstrated that gp350 is the target of the EBV ADCC. Interestingly, this ADCC was comparable to that obtained against the EBV-superinfected (coated) Raji cell expressing the same percentage of gp350 positivity as the two clones. No cytotoxic activity was detected against either nontransfected (gp350-negative) Raji cells or cells transfected with the vector [pZIP-neo-SV(X)1] lacking the gp350 gene. In addition to demonstrating that gp350 is a target molecule for EBV-specific ADCC, our approach in using NK-resistant transfectants provides a lead for probing the role of cell surface-associated viral antigens in specific cellular killing and immunosurveillance.
Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state (2007)

Alterations of DNA methylation are one of the most consistent epigenetic changes in human cancers. Human cancers generally show global DNA hypomethylation accompanied by region-specific hypermethylation. Alterations of DNA methylation may result in chromosomal instability as a result of changes in chromatin structure. DNA hypermethylation of CpG islands silences various tumor-related genes. Alterations of DNA methylation are frequently observed in cancers associated with chronic inflammation and/or persistent infection with viruses or other pathogenic microorganisms, such as hepatitis B or C viruses, Epstein-Barr virus, human papillomavirus and Helicobacter pylori, or with cigarette smoking. Accumulating evidence suggests that alterations of DNA methylation are involved even in the early and precancerous stages. On the other hand, in patients with cancers, aberrant DNA methylation is significantly associated with poorer tumor differentiation, tumor aggressiveness and poor prognosis. Precancerous conditions showing alterations of DNA methylation may progress rapidly and generate more malignant cancers. DNA methyltransferase (DNMT) 1 over-expression is not a secondary result of increased cell proliferative activity but is significantly correlated with the CpG island methylator phenotype, which is defined as frequent DNA hypermethylation of C-type CpG islands that are usually methylated in a cancer-specific (not age-dependent) manner. Splicing alteration of DNMT3b may result in chromosomal instability through DNA hypomethylation of pericentromeric satellite regions. Alteration of DNA methylation may become an indicator for carcinogenetic risk estimation and early diagnosis of cancers and a biological predictor of poor prognosis in patients with cancers. Correction of DNA methylation status may offer a new strategy for prevention and therapy of cancers.
High-efficiency single-frequency cw ring dye laser (1979)

A cw dye laser is described that provides tunable, high-power single-frequency radiation over the entire visible spectrum. Central to the design is the elimination of spatial hole burning and the enhancement of mode competition through the use of a ring resonator and a very-low-loss Faraday-effect device to select a single traveling-wave direction. As much as 0.9 W of single-frequency 580-nm radiation is available from rhodamine 6G using a 4-W 514.5-nm argon-ion laser pump. Intracavity second-harmonic generation has produced over 20 mW of tunable single-frequency ultraviolet radiation under the same conditions.
Extending Mondrian memory protection (2010)

I would like to thank a couple of people from the Vienna University of Technology, my family, and friends who have contributed to this thesis or helped me during my studies.First of all, a big thank you to my academic advisors Engin Kirda and Christopher Krgel for the inspiration for the topic and their many comments and suggestions that helped me keep headed in the right direction.Also, the fellow students at the SecLab offered a great environment to work and have a good time in.My parents Arno and Maria deserve a very big thank you for supporting me during my studies and also on everything else I have ever done.To my elder brother Philipp, who taught me computer programming in the first place, and his partner Theresa, my younger brother Maximilian, and my sister Eva Maria, I also want to say thank you for supporting me and being a very important part of my life.Of course, a very special and warm thank you to my partner Manuela for her encouragement and endless hours of listening to my, at times probably quite geeky, thoughts and ideas.At last, I want to thank all my friends for making sure I
The Triumph of Economics; Or, 'Rationality' Can Be Dangerous to Your Reasoning (2020)

This chapter examines both closely and critically some of the work of a particular economist, Gary Becker. Indeed, Becker is judged to be too extreme by many of his fellow economists, for reasons that will become apparent in what follows. With human capital theory and the new household economics, for example, orthodox neo-classical reasoning has been well established in areas where it was previously absent, education and the family. At the same time, specialists from fields that do consider social questions are often attracted to the economic way of modelling behavior because of the analytical power provided by the assumption of individual rationality. In addressing a colonised topic, the economics approach involves identifying an empirical anomaly, as far as the assumption of fixed tastes is concerned, and corresponding social factors with which to address it factors considered by other disciplines.
Data Collection in Underwater Sensor Networks based on Mobile Edge Computing (2019)

With the rapid developments in edge devices and wireless technologies, the underwater wireless sensor networks (UWSNs) are in the process of vigorous development. In UWSNs, the traditional multi-hop data collection methods have some disadvantages such as high power consumption, severe unbalance in power consumption, and so on. In recent years, mobile edge elements (such as an autonomous underwater vehicle, AUV) are widely used in underwater data collection to solve energy consumption imbalance problems. However, the existing methods do not fully consider the efficient mobile edge computing and the real mobility model of AUV in the underwater environment. In this paper, we propose a data collection scheme based on a mobility model of mobile edge elements under water. In this model, the mobility direction and velocity are fully considered, which are close to the mobility characteristic of AUVs in the stable 3D environment. By using computing, storage, and mobility abilities of AUVs, a target selection algorithm is designed to calculate the mobility path of data collection for AUV. The theoretical analysis and experimental results show that the proposed method improves the efficiency of data collection, reduces the power consumption of nodes, and extends the network lifetime.
Exposing I/O concurrency with informed prefetching (2002)

Informed prefetching provides a simple mechanism for I/O-intensive, cache-ineffective applications to efficiently exploit highly-parallel I/O subsystems such as disk arrays. This mechanism, dynamic disclosure of future accesses, yields substantial benefits over sequential readahead mechanisms found in current file systems for non-sequential workloads. This paper reports the performance of the Transparent Informed Prefetching system (TIP), a minimal prototype implemented in a Mach 3.0 system with up to four disks. We measured reductions by factors of up to 1.9 and 3.7 in the execution time of two example applications: multi-file text search and scientific data visualization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Vorwort (1994)

Das Thema dieses Buches ist die Verantwortbarkeit des praktischen Einsatzes von Programmen. Die Grundthese lautet: Verantwortung muß einzelnen Menschen zugeordnet werden, und Voraussetzung der Wahrnehmung von Verantwortung ist die Einsicht in die zu verantwortenden Eigenschaften des technischen Systems.
Local Phase Decomposition as a Cause of Polarization Fatigue in Ferroelectric Thin Films (2006)

We show that lead zirconate titanate thin films undergo local phase decomposition during fatigue. The original remanent polarization of the fatigued film is completely restored after furnace annealing in an O2 atmosphere, following a significant regrowth of a perovskite phase from the pyrochlorelike structure. By comparing our data with other researchers' work on annealing of fatigued ferroelectric samples, we conclude that local phase separation is the generic reason for electrical fatigue in ferroelectrics. A fatigue model is proposed in order to interpret our experimental data.
Molecular pathways in bone marrow homing: dominant role of α4β1 over β2-integrins and selectins (2001)

The specific retention of intravenously administered hemopoietic cells within bone marrow is a complex multistep process. Despite recent insights, the molecular mechanics governing this process remain largely undefined. This study explored the influence of beta(2)-integrins on the homing to bone marrow and repopulation kinetics of progenitor cells. Both antifunctional antibodies and genetically deficient cells were used. In addition, triple selectin-deficient mice were used as recipients of either deficient (selectin or beta(2)) or normal cells in homing experiments. The homing patterns of either beta(2) null or selectin null cells into normal or selectin-deficient recipients were similar to those of normal cells given to normal recipients. Furthermore, spleen colony-forming units and the early bone marrow repopulating activity for the first 2 weeks after transplantation were not significantly different from those of control cells. These data are in contrast to the importance of beta(2)-integrin and selectins in the adhesion/migration cascade of mature leukocytes. The special bone marrow flow hemodynamics may account for these differences. Although early deaths after transplantation can be seen in recipients deficient in CD18 and selectin, these are attributed to septic complications rather than homing defects. However, when beta(2)- or selectin-null donor cells are treated with anti-alpha(4) antibodies before their transplantation to normal or selectin-deficient recipients, a dramatic inhibition of homing (>90%) was found. The data suggest that the alpha(4)beta(1)/vascular cell adhesion molecule-1 pathway alone is capable of providing effective capture of cells within the bone marrow, but if its function is compromised, the synergistic contribution of other pathways, that is, beta(2)-integrins or selectins, is uncovered.
Neue oder seltene Reptilien und Frösche des Naturhistorischen Museums in Hamburg (1912)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Deep Face Recognition under Eyeglass and Scale Variation Using Extended Siamese Network (2017)

Face recognition has attracted much attention from researchers for past decades. Recently, with the development of deep learning, a deep neural network is adopted by face recognition system and better performance is obtained. Many works on metric learning have been done in the deep neural network. Meanwhile, there are several variation problems existing in face recognition, such as profile face image, low-resolution face image, different age of face image, face image wearing eyeglass, etc. In this paper, targeting at different kinds of variation problems, we proposed a novel network structure, called Extended Siamese Network. Another contribution is that a new loss function is proposed, to further take inter-class information into account based on the center loss function. The experiments show that recognition accuracy is improved in comparison with the other state-of-art methods.
Retinal gene therapy 1998: summary of a workshop. (1998)

The 1998 Workshop on Retinal Gene Therapy evaluated the potential of gene therapy in treatment of retinal disease. Academic, industry, and private foundation representatives attended. Topics included: determing which retinal diseases are likely candidates for gene therapy, specific retinal degenerations and nonspecific neuronal survival mechanisms, design and use of viral and retroviral vectors in achieving regulated gene expression, animal models of retinal degeneration and associated therapies, human trials, and alternatives to gene therapy. The discussion of human trials explored the justification for moving from animal models to human testing, patient population concerns, lessons learned from previous human gene therapy trials, and the role of industry in support of basic and clinical research.
‘But Most of all mi Love me Browning’: The Emergence in Eighteenth and Nineteenth-Century Jamaica of the Mulatto Woman as the Desired (2000)

One of the most common threads in the Caribbean tapestry races which have populated the region over the last five centuries largely through forced or voluntary migration, is that there have emerged mixtures of the different racial groups. A large proportion of Caribbean women and men are referred to euphemistically as ‘mixed race’. The terms used to describe people of mixed race vary by territory and have been incrementally added to or changed over time. The original nomenclatures such as sambo, musteephino, mulatto, creole, etc. have been replaced at present to include terms like brown skin, mulatto, clear skin, light skin, red-nigger, dougla and browning. The title of the article comes from a contemporary dancehall song in Jamaica in which the black singer, Buju Banton, unwittingly echoes an unspoken yet shared notion of female desirability in the Caribbean: a preference for ‘brown’ as opposed to black women or unmixed women. In the ongoing constructions of femininity in the region, class and skin colour have intersected with race to produce hierarchies and stereotypes of femininity based on racial mixing. Drawing on some of the historical data available, particularly that of the pioneering research in this area produced by Lucille Mathurin in 1974, this article interrogates some aspects of miscegenation in the Jamaican past, to configure these with gender, race and class relations in the present. The article does not attempt to arrive at conclusive findings but to contribute to the ongoing process in the region, and elsewhere, of differentiating the category ‘woman’ in historiography and sociology.
Field-testing IMPACT EPIC research results in itanium 2 (2004)

Explicitly-Parallel Instruction Computing (EPIC) provides architectural features, including predication and explicit control speculation, intended to enhance the compiler's ability to expose instruction-level parallelism (ILP) in control-intensive programs. Aggressive structural transformations using these features, though described in the literature, have not yet been fully characterized in complete systems. Using the Intel Itanium 2 microprocessor, the SPECint2000 benchmarks and the IMPACT Compiler for IA-64, a research compiler competitive with the best commercial compilers on the platform, we provide an in situ evaluation of code generated using aggressive, EPIC-enabled techniques in a reality-constrained microarchitecture. Our work shows a 1.13 average speedup (up to 1.50) due to these compilation techniques, relative to traditionally-optimized code at the same inlining and pointer analysis levels, and a 1.55 speedup (up to 2.30) relative to GNU GCC, a solid traditional compiler. Detailed results show that the structural compilation approach provides benefits far beyond a decrease in branch misprediction penalties and that it both positively and negatively impacts instruction cache performance. We also demonstrate the increasing significance of runtime effects, such as data cache and TLB, in determining end performance and the interaction of these effects with control speculation.
BRCA1 Regulates Gene Expression for Orderly Mitotic Progression (2005)

Germline mutations of the BRCA1 gene confer an increased risk for breast cancer and ovarian cancer. To study the contribution of BRCA1 to sporadic cancers, which often exhibit reduced BRCA1 expression, we tested the effect of knocking down BRCA1 on gene expression in human prostate (DU-145) and breast (MCF-7) cancer cells. DNA microarray and confirmatory RNA analyses revealed that BRCA1 small interfering (si) RNA caused down-regulation of multiple genes implicated in the mitotic spindle checkpoint (eg., BUB1B, HEC, and STK6), chromosome segregation (eg., ESPL1, NEK2, and PTTG1), centrosome function (eg., ASPM), cytokinesis (eg., PRC1, PLK, and KNSL2), and the progression into and through mitosis (eg., CDC2, and CDC20). Cells treated with BRCA1-siRNA showed attenuation of the mitotic spindle checkpoint; but not several G2 checkpoints. Finally, BRCA1 knockdown caused the accumulation of multinucleated cells, suggesting a defect in cytokinesis. We conclude that BRCA1 regulates gene expression for orderly mitotic progression.
[Regulation of calcification by bisphosphonates]. (2004)

Etidronate, an analogue of first generation of bisphosphonates, has inhibitory actions on mineralization and hydroxyapatite crystal formation, which is therefore used as a drug to treat ectopic ossification in cases with total hip arthroplasty and spinal cord injury. The effect of bisphosphonates to prevent calcification could be associated with the physical property to attach tightly to hydroxyapatite crystals in bone matrix. A recent investigation suggested that bisphosphonates might prevent arterial calcification through a mechanism associated with the enhanced production of parathyroid hormone-related peptide from vascular smooth muscle cells. A derivative of bisphosphonates to inhibit vascular calcification in atherosclerosis is expected and should be developed in the near future.
Digitalis-like Compounds: the Discovery of the O-aminoalkyloxime Group as a Very Powerful Substitute for the Unsaturated γ-Butyrolactone Moiety (2005)

Digitalis compounds are used in the treatment of congestive heart failure as positive inotropic agents; their action is mainly due to the inhibition of the Na(+),K(+)-ATPase. A well-known drawback is their arrhythmogenic potential together with a low therapeutic index. Digitalis compounds are characterized by a cis/trans/cis steroidal skeleton with an alpha,beta-unsaturated lactone (gamma-butyrolactone) in the 17beta-position, a 14beta-hydroxy group and a 3beta-hydroxy group, the latter usually linked to one or more sugar rings. The first three moieties are considered essential for inotropic activity, while the glycosides are responsible for the pharmacokinetics of the compounds. This review briefly reports on some of the replacements for the unsaturated gamma-butyrolactone moiety and then summarizes the work at Prassis that led to the discovery of the O-aminoalkyloxime group as a very powerful substitute. We also report on the development of new steroidal compounds which act as digitalis-like inhibitors of the Na(+),K(+)-ATPase, without any of the chemical features that are peculiar to naturally occurring digitalis glycosides.
Antibodies against type II phospholipase A<sub>2</sub> prevent renal injury due to ischemia and reperfusion in rats (1998)

This study was performed to determine the involvement of type II phospholipase A2 (PLA2-II) in renal injury caused by ischemia and reperfusion. Ischemia and reperfusion significantly elevated levels of blood urea nitrogen and serum creatinine in rats. These increases were significantly reduced by i.v. administration of rabbit IgG F(ab')2 fragments against rat PLA2-II. Increased levels of acid-stable PLA2 activity in the kidney were caused by ischemia and reperfusion, and were suppressed by administration of anti-PLA2-II F(ab')2. Increased levels of myeloperoxidase activity, a marker of neutrophil infiltration, in the kidney were also reduced after anti-PLA2-II F(ab')2 treatment. These results suggest that PLA2-II plays a pivotal role in pathogenesis of ischemia and reperfusion injury through induction of neutrophil infiltration.
Quantitative Assay of Paravaccinia Virus Based on Enumeration of Inclusion-Containing Cells (1972)

Bovine paravaccinia virus produces cytoplasmic inclusion bodies on infection of bovine embryonic kidney cells; these were easily recognized when stained with acridine orange or May-Grünwald-Giemsa stain. The inclusions could be shown to contain newly synthesized deoxyribonucleic acid by autoradiography. Counts of inclusion-containing cells decreased when virus suspensions were treated with immune serum before being used to inoculate cell cultures. At 24 hr after infection, the number of cells containing inclusions was directly proportional to the concentration of infectious virus inoculated. These observations provide the basis for a virus assay which is simpler, faster, and more sensitive than the plaque assay.