gebhart/patrepeval huggingface dataset:
Concepts for the design of 5‐HT<sub>1A</sub> serotonin agonists and antagonists (1992)

Abstract The accessibility and use of a standard 5‐HT 1A agonist radioligand ([ 3 H]8‐hydroxy‐2‐(dipropylaminotetralin) has resulted in the availability of a large amount of binding data on various serotonergic agents. This, in turn, has permitted the formulation of structure—affinity relationships (SAFIR). By contrast, much less information is available concerning the agonist and antagonist activity of these agents. This is primarily due to a lack of standard evaluation procedures, controversy regarding the presynaptic versus postsynaptic nature of certain models, and the recent realization that many 5‐HT 1A agents are partial agonists. Thus, it has been difficult to formulate structure—activity relationships (SAR) for these agents. The present review examines the various classes of 5‐HT 1A serotonergic agents and the available data on their 5‐HT 1A agonist and antagonist activity with the aim of formulating SAR. These SAR should provide useful information for the subsequent design of 5‐HT 1A ‐selective agonists and antagonists. © 1992 Wiley‐Liss, Inc.
Mössbauer-Effekt-Untersuchungen über die Platzbesetzung der Kationen in Mischkristallformiaten zweiwertiger Metalle (1973)

Article Mössbauer-Effekt-Untersuchungen über die Platzbesetzung der Kationen in Mischkristallformiaten zweiwertiger Metalle was published on June 1, 1973 in the journal Zeitschrift für Physikalische Chemie (volume 85, issue 1-4).
Inter-vehicle spread spectrum communication and ranging system with concatenated EOE sequence (2001)

Proposes a method for designing spread sequences for a spread spectrum (SS) communication and ranging system. The proposed sequence is composed by concatenated equivalently odd and even (EOE) inner-sequences and an M outer sequence. We have previously proposed EOE sequences that have equivalently good properties of both even and odd correlation, what are important features for acquisition and demodulation in SS communications. Usually, simple concatenation of pseudonoise-sequences results in sequences with bad autocorrelation properties. Unlike the latter, concatenation of EOE inner sequences result in sequences with good correlation properties, exhibiting low sidelobe peaks, what is useful for achieving stable acquisition. The proposed sequences have long period. Therefore, the single concatenated EOE sequence is suitable for a spread spectrum system with both communication and ranging functions.
Seismic detection and analysis of icequakes at Columbia Glacier, Alaska (2007)

Contributions to sea level rise from rapidly retreating marine‐terminating glaciers are large and increasing. Strong increases in iceberg calving occur during retreat, which allows mass transfer to the ocean at a much higher rate than possible through surface melt alone. To study this process, we deployed an 11‐sensor passive seismic network at Columbia Glacier, Alaska, during 2004–2005. We show that calving events generate narrow‐band seismic signals, allowing frequency domain detections. Detection parameters were determined using direct observations of calving and validated using three statistical methods and hypocenter locations. The 1–3 Hz detections provide a good measure of the temporal distribution and size of calving events. Possible source mechanisms for the unique waveforms are discussed, and we analyze potential forcings for the observed seismicity.
A multipurpose MRI phantom based on a reverse micelle solution (1996)

Many chemical solutions for use in magnetic resonance imaging phantoms have been reported in the literature. Each of these solutions has its application-specific advantages and disadvantages. We propose a single reverse micelle phantom solution, which, although not a universal phantom solution, may find applications in testing of the radio frequency transmit and receive fields of an imaging coil, the homogeneity of the static magnetic field, and the suppression in a fat or water saturation imaging sequence. The solution is thermodynamically stable and biologically inert, it possesses a smaller standing wave artifact than water, and its overall spin lattice relaxation times may be adjusted.
Comparison of Preparative HPLC/MS and Preparative SFC Techniques for the High-Throughput Purification of Compound Libraries (2003)

A diverse set of 16 high-throughput organic synthesis libraries, consisting of 48 samples per library, has been purified by both preparative supercritical fluid chromatography (SFC) and preparative high-performance liquid chromatography (HPLC). This paper details the relative effectiveness of these two purification techniques in terms of success, yield, and purity of final product.
Real-Time Aerodynamic Parameter Estimation Without Air Flow Angle Measurements (2012)

A technique for estimating aerodynamic parameters in real time from flight data without air flow angle measurements is described and demonstrated. The method is applied to simulated F-16 data, and to flight data from a subscale jet transport aircraft. Modeling results obtained with the new approach using flight data without air flow angle measurements were compared to modeling results computed conventionally using flight data that included air flow angle measurements. Comparisons demonstrated that the new technique can provide accurate aerodynamic modeling results without air flow angle measurements, which are often difficult and expensive to obtain. Implications for efficient flight testing and flight safety are discussed.
Biodistribution of Radiolabeled Lipid–DNA Complexes and DNA in Mice (1998)

The tissue biodistribution and expression of [33P]DNA-1-[2-[9-(Z)-octadecenoyloxy]ethyl]]-2-[8](Z)-heptadece nyl]-3 -[hydroxyethyl]imidazolinium chloride (DOTIM):cholesterol complexes and 33P-radiolabeled DNA expressing chloramphenicol acetyl transferase (CAT; 4.7 kB) were studied after intravenous (iv) injection in ICR mice. Mice were injected with 200 microL of complex containing DNA at 3 mg/kg or DNA alone. One group received 8 microCi of radioactivity and were sacrificed at 5 and 20 min, and 1, 2, 4 and 24 h post-dose (n = 4/time point). A second group received the equivalent of 3.9 microCi of radioactivity and were sacrificed at 20 min, and 2 and 24 h for subsequent whole body autoradiographic analysis (WBA; n = 2/time point). The tissue distribution of intact DNA was assessed by Southern blot at 24 h post-dose, whereas the integrity of complexes and DNA incubated in heparinized whole blood was studied separately. In further studies, the time course of expression in lung tissue over a 48-h period was examined, and the relative lung-expression of purified open circular (OC) versus supercoiled (SC) DNA at 24 h was evaluated. Approximately 42% of the radioactivity was found in the lungs 5 min after injection and about half this percentage was found in the liver. By 2 h, only 5% remained in the lungs, but 48% was present in the liver. No other tissue accumulated >5% of the dose throughout the duration of the study. WBA radiograms confirmed the tissue distribution results and highlighted significant accumulation of radioactivity in bone over time. Southern Blot analysis demonstrated intact DNA in many tissues 24 h after dosing. In contrast, the majority of DNA incubated in blood was degraded within 2 h, although the complexes afforded some protection relative to DNA alone. The OC DNA expressed equivalently to SC DNA in lung tissue (OC = 1035 +/- 183 pg; SC = 856 +/- 257 pg/mg soluble protein, n = 6, mean +/- SEM) at 24 h, and detectable levels of CAT were present within 2 h of dosing (21.3 +/- 7.2 pg, n >/= 8, mean +/- SD). The results confirm that DNA-DOTIM:cholesterol complexes are initially deposited in the lungs after iv administration.
Simple proofs of the minimum phase property of the prediction error filter (1983)

New simple proofs are given for the minimum phase property of the optimal prediction error filter.
Update on Soft Tissue Augmentation (1992)

This article reviews all of the materials currently available for soft tissue augmentation as well as those that have recently been available and those undergoing current evaluation for possible use in the future. Techniques, side effects, and tips on the use of each of the substances are described, and the future of soft tissue augmentation is discussed.
Synthesis, Characterization, and Reversible Oxygenation of .mu.-Alkoxo Diiron(II) Complexes with the Dinucleating Ligand N,N,N',N'-Tetrakis{(6-methyl-2-pyridyl)methyl}-1,3-diamino- propan-2-olate (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, Characterization, and Reversible Oxygenation of .mu.-Alkoxo Diiron(II) Complexes with the Dinucleating Ligand N,N,N',N'-Tetrakis{(6-methyl-2-pyridyl)methyl}-1,3-diamino- propan-2-olateYoshihito Hayashi, Takayuki Kayatani, Hideki Sugimoto, Masatatsu Suzuki, Katsuhiko Inomata, Akira Uehara, Yasuhisa Mizutani, Teizo Kitagawa, and Yonezo MaedaCite this: J. Am. Chem. Soc. 1995, 117, 45, 11220–11229Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ja00150a020https://doi.org/10.1021/ja00150a020research-articleACS PublicationsRequest reuse permissionsArticle Views1088Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Self-starting optoelectronic oscillator for generating ultra-low-jitter high-rate (10GHz or higher) optical pulses (2003)

We demonstrate a novel, self-starting optoelectronic oscillator based on an electro-absorption modulator in a fiber-extended cavity for generating an optical pulse stream with high-rate and ultra-low jitter capabilities. Optical pulses at 10GHz repetition rate are demonstrated with >90dBc/Hz side-mode suppression and the lowest timing jitter (42fs in the 100Hz-1MHz range) reported to date for a self-starting source. Along with the optical pulse stream, the oscillator also generates a 10GHz electrical signal with ultra-low phase noise.
Control Plug Lateral Coupling Memory Cell Utilizing Uniform Channel Fowler–Nordheim Operation (2015)

In this letter, we propose a control-plug (CP) structure logic nonvolatile memory (LNVM) fabricated by a standard logic CMOS process for mobile applications with low-power-consumption requirement. The operating concept of this cell is based on the use of a lateral capacitance coupling between a bar-type CP and a floating gate. Owing to the unique bar-type CP-coupling method and CP-sharing cell array structure, the novel cell has a coupling ratio of over 94% with the lowest fill factor of 344 as a Fowler-Nordheim (FN)-operated LNVM. Furthermore, because of the high coupling ratio and divided-bias operating method, this cell utilizes a uniform-channel FN tunneling program and erase method using a 3.3 V logic peripheral overdrive tolerable voltage of 5.5 V.
Satellite-aided mobile radio concepts study: Concept definition of a satellite-aided mobile and personal radio communication system (1979)

The satellite system requires the use of a large satellite antenna and spacecraft array power of about 12 kW or more depending on the operating frequency. Technology developments needed include large offset reflector multibeam antennas, satellite electrical power sybsystems providing greater than 12 kW of power, signal switching hardware, and linearized efficient solid state amplifiers for the satellite-aided mobile band. Presently there is no frequency assignment for this service, and it is recommended that an allocation be pursued. The satellite system appears to be within reasonable extrapolation of the state of the art. It is further recommended that the satellite-aided system spacecraft definition studies and supporting technology development be initiated.
Primary Culture of Human Mammary Epithelial Cells Embedded in Collagen Gels<xref ref-type="fn" rid="fn2">2</xref> (1980)

Human mammary epithelial cells were dissociatd from mastectomy tissues. The contaminating fibroblasts were removed by the use of Percoll density-gradient centrifugation, which utilizes the difference in buoyant densities between epithelial cells and fibroblasts. A preparation highly enriched for mammary epithelial cells ws then embedded in collagen gel and cultured in Ham's F12 medium containing 12.5% horse serum, 2.5% fetal calf serum, 0.1 microgram cholera toxin/ml, an extract prepared from human male urine (L microgram protein/ml), and a hormone combination of 10 microgram insulin/ml, 10 microgram human placental lactogen/ml, 1 microgram aldosterone/ml, and 0.5 microgram hydrocortisone/ml. Sustained growth leading to an increase of tenfold to thirtyfold in cell number over the initial value was accomplished in primary culture, and this growth was maintained even after passage to secondary culture. Deletion of either the urine extract or the hormone combination resulted in less than optimal growth. Subsequent studies showed that hydrocortisone alone could replace the hormone combination. In addition, urine extract could be replaced by extracts prepared from human kidneys or brains. The collagen gel system provies a reproducible and consistent method for sustained three-dimensional growth of mammary epithelial cells from human breast tissue in primary as well as passaged cultures.
Do Leaders' Personalities Really Matter? (2002)

Abstract This is an introductory chapter, which starts with a general discussion of whether leaders’ personalities really matter in determining the outcome of democratic elections, and then considers a number of preliminary points before the country analyses are presented in the following six chapters. The first point is to differentiate between the indirect influences a leader can have on voters and an election outcome (via his influence on his political party or government or administration) and the direct influence of a candidate’s personality or personal characteristics; this book is about the latter. The second point is to define what is meant by ‘personality or personal characteristics’, and the next two points are a discussion of why leaders’ attributes might, or might not, be thought to matter. The fifth point is to suggest analytical strategies for disentangling the effects of leaders’ personalities or personal characteristics from other factors; the three advanced are the experimental, improved–prediction and counterfactual strategies. Next, previous analytical findings are presented for the six countries studied in the book (United States, Britain, France, Germany, Canada and Russia), and finally, hypotheses are offered for explaining when the impact of candidates’ personalities or personal characteristics might be greatest.
Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma (2013)

This study suggests that ABT-888 has the clinical potential to enhance the current standard treatment for GBM, in combination with conventional chemo-radiotherapy. Interestingly, our results suggest that the use of PARP inhibitors might be clinically significant in those patients whose tumour is MGMT-unmethylated and currently derive less benefit from TMZ.
Advanced Oxidation Processes Against Phenolic Compounds In Wastewater Treatment (1995)

Abstract Experimental research into the oxidative treatment of aqueous solutions and wastewaters containing phenolic compounds was undertaken. Ozone, supported by short wavelength UV-irradiation, hydrogen peroxide and titanium dioxide catalyst, was selected as an oxidant in the following combinations: O3, O3/H2O2, O3/UV, O3/TiO2, O3/UV/H2O2 and O3/UV/TiO2. 5-Methylresorcinol was chosen as a model compound for the experiments with synthetic phenolic solutions. The results obtained from these experiments were compared with the results of oxidative purification of wastewaters produced from the thermal treatment of oil shale in Estonia. Key Words: OzoneWastewater TreatmentOil Shale5-MethylresorcinolHydrogen PeroxideUVTitanium DioxideOzone/Hydrogen PeroxideOzone UV RadiationOzone/TitaniaOzone/UV/Hydrogen PeroxideOzone/UV/TitaniaBOD5/COD ratio
Synergistic Solvent Extraction of Alkaline Earth Cations by Mixtures of Di-<i>n</i>-octylphosphoric Acid and Stereoisomers of Dicyclohexano-18-crown-6 (1999)

The partitioning of Ca(II), Sr(II), and Ba(II) in solvent extraction systems comprising di-n-octylphosphoric acid (HDOP) and individual stereoisomers of dicyclohexano- 18-crown-6 (DCH18C6) in toluene has been investigated at 23(2) °C. Results of vapor pressure osmometric experiments, continuous variation studies, single- and double-extractant dependencies, and acid dependencies have been used to determine the stoichiometries of the extracted complexes. Extraction of Ca(II) by HDOP alone affords Ca(H(DOP)2)2·HDOP as the extracted species, and no synergism is observed in the presence of DCH18C6, presumably due to the strong complexation of Ca(II) with HDOP and the strained complexes this cation forms with DCH18C6. In the absence of DCH18C6, Sr(II) and Ba(II) are extracted as the M(H(DOP)2)2·2HDOP (M = Sr or Ba) complexes. Upon addition of DCH18C6, the extracted complexes are formulated as M(DCH18C6)(H(DOP)2)2 (M = Sr or Ba), with Ba(II) showing greater synergistic effects than Sr(II). The effectiveness of the DCH18C6 stereoisomers as synergists decreases in the following order: cis−syn−cis > cis−anti−cis > cis−trans > trans−syn−trans > trans−anti−trans. This sequence has been explained by correlating the logarithm of the synergistic adduct formation constants with the ligand strain energies of the DCH18C6 stereoisomers calculated using molecular mechanics methods. Those stereoisomers having the largest strain energies afford the lowest extraction and synergistic adduct formation constants.
Identification and Separation of Thy-1 Positive Mouse Spleen Cells Active in Natural Cytotoxicity and Antibody-Dependent Cell-Mediated Cytotoxicity (1979)

The expression of the Thy-1 antigen on mouse spleen cells responsible for NK activity and ADCC was investigated by using a monoclonal IgM anti-Thy-1.2 antibody. Both C-mediated cytotoxicity and the fluorescence-activated cell sorter were used to fractionate cells. The effector cells were found to be heterogeneous in their expression of Thy-1. Effector cells from nude BALB/c mice were predominantly Thy-1 positive; some of the NK cells in CBA spleens appeared to be Thy-1 positive, but at least one-third of the lytic activity was due to Thy-1 negative cells. The effects of treatments on NK cytotoxicity and ADCC were very similar, supporting the hypothesis that the same cells mediate both activities.
A Reflectionless Wave-Guide Termination (1951)

A reflectionless termination design is described which, in principle, can be adapted to wave-guide or coaxial transmission lines. Reflection coefficients of 0.001 were obtained experimentally with X-band wave-guide terminations. The termination comprises a section of transmission line into which is fitted a tunable sliding load. The sliding load is tuned to be reflectionless by means of the ``sliding load'' method of measuring reflection coefficients. The termination can be operated over a wide frequency range but must be retuned each time the frequency is changed. The wave-guide circuit of the load is analyzed and design equations are derived. The reflectionless wave-guide termination is primarily useful as a reference standard for microwave impedance bridges.
Multi-frequency processing for lumen enhancement with wideband intravascular ultrasound (2008)

The need to further improve the spatial resolution of intravascular ultrasound (IVUS) may drive the transducer center frequency even higher than the current 40 MHz range. Using a higher frequency results in stronger scattering echoes from the blood and may hamper visualization of the arterial lumen. This paper presents a multi-frequency processing method to enhance the arterial lumen by extracting the different scattering characteristics between blood and arterial tissues. A novel wideband catheter enables transmitting a broadband excitation pulse and processing signals in different frequency ranges, allowing detection of the signal ratio between the high (60 MHz) and low (25 MHz) frequencies. To evaluate this method, an in vitro experiment with porcine blood will be described. The lumen enhancement method will be demonstrated in vivo in an animal study.
Sports and Antitrust: Should College Students Be Paid to Play (1990)

a survey of professional football players indicated that two thirds had never received a college degree; similar results had previously been obtained for college basketball players).The recent Norby Walters trial revealed some of the academic abuses occurring on college campuses.See, 25 The most thorough antitrust analysis undertaken to date concludes that the NCAA restraints do not violate the antitrust laws.
Localization of Human Cytomegalovirus Structural Proteins to the Nuclear Matrix of Infected Human Fibroblasts (1998)

The intranuclear assembly of herpesvirus subviral particles remains an incompletely understood process. Previous studies have described the nuclear localization of capsid and tegument proteins as well as intranuclear tegumentation of capsid-like particles. The temporally and spatially regulated replication of viral DNA suggests that assembly may also be regulated by compartmentalization of structural proteins. We have investigated the intranuclear location of several structural and nonstructural proteins of human cytomegalovirus (HCMV). Tegument components including pp65 (ppUL83) and ppUL69 and capsid components including the major capsid protein (pUL86) and the small capsid protein (pUL48/49) were retained within the nuclear matrix (NM), whereas the immediate-early regulatory proteins IE-1 and IE-2 were present in the soluble nuclear fraction. The association of pp65 with the NM resisted washes with 1 M guanidine hydrochloride, and direct binding to the NM could be demonstrated by far-Western blotting. Furthermore, pp65 exhibited accumulation along the nuclear periphery and in far-Western analysis bound to proteins which comigrated with proteins of the size of nuclear lamins. A direct interaction between pp65 and lamins was demonstrated by coprecipitation of lamins in immune complexes containing pp65. Together, our findings provide evidence that major virion structural proteins localized to a nuclear compartment, the NM, during permissive infection of human fibroblasts.
Treating patients of myelodysplastic syndrome with antithymocytic globulin—should we be more selective? (2003)

We read with interest the article by Steensma et al[1][1] on use of antithymocytic globulin (ATG) for the management of myelodysplastic syndrome (MDS). This study showed a very poor response to ATG therapy with substantial toxicity in all of the 8 MDS patients and suggests that clinicians be more