gebhart/patrepeval huggingface dataset:
XQuery containment in presence of variable binding dependencies (2005)

Semantic caching is an important technology for improving the response time of future user queries specified over remote servers. This paper deals with the fundamental query containment problem in an XQuery-based semantic caching system. To our best knowledge, the impact of subtle differences in XQuery semantics caused by different ways of specifying variables on query containment has not yet been studied. We introduce the concept of variable binding dependencies for representing the hierarchical element dependencies preserved by an XQuery. We analyze the problem of XQuery containment in the presence of such dependencies. We propose a containment mapping technique for nested XQuery in presence of variable binding dependencies. The implication of the nested block structure on XQuery containment is also considered. We mention the performance gains achieved by a semantic caching system we build based on the proposed technique.
Studies on chitin. 13. New polysaccharide/polypeptide hybrid materials based on chitin and poly(.gamma.-methyl L-glutamate) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on chitin. 13. New polysaccharide/polypeptide hybrid materials based on chitin and poly(.gamma.-methyl L-glutamate)Keisuke Kurita, Akira Yoshida, and Yoshiyuki KoyamaCite this: Macromolecules 1988, 21, 6, 1579–1583Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://doi.org/10.1021/ma00184a007RIGHTS & PERMISSIONSArticle Views403Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (603 KB) Get e-Alerts Get e-Alerts
In vitro cytotoxic effects of tumor necrosis factor‐α in human breast cancer cells may be associated with increased glucose consumption (1997)

Tumor necrosis factor-alpha inhibited growth of cultured MCF-7 human breast cancer cells in a dose dependent manner. Tumor necrosis factor-alpha also markedly increased glucose consumption, and its cytotoxicity was modified by glucose concentrations in the growth medium; higher glucose levels were associated with increased cell survival. However, when the cells were perfused in physiological conditions, very high levels of tumor necrosis factor-alpha (200 ng/ml) in the perfusion solution had no inhibitory effects. Moreover, tumor necrosis factor-alpha had no effects on 31P nuclear magnetic resonance spectra of the perfused cells. In the traditional growth inhibition assays, cells are incubated for several days with a drug, a situation where their metabolism is altered due to the depletion of nutrients, the accumulation of toxic waste materials and pH changes. Perfusion experiments are more relevant to in vivo conditions, and may be used for studying metabolic processes and the mechanisms of action of therapeutic agents.
Transepidermal Potassium Ion, Chloride Ion, and Water Flux across Delipidized and Cellophane Tape-Stripped Skin (1990)

The skin barrier was evaluated as a function of transepidermal water loss (TEWL) and electrolyte loss. Combination electrodes for chloride and pH determinations and a potassium ion electrode were utilized. Delipidization of the skin did not impair the electrolyte barrier, but did damage the epidermal water barrier. Cellophane tape stripping of normal stratum corneum resulted in an increase in outward transepidermal potassium and chloride ion flux, an increase in skin surface pH, and an increase in TEWL. It appears that damage to the epidermal water barrier does not necessarily result in damage to the epidermal electrolyte barrier. We found the potassium electrode facile to use and believe that a combination potassium electrode would be useful for investigating and assessing the epidermal electrolyte barrier.
Use of Aortic Balloon Occlusion to Decrease Blood Loss During Sacral Tumor Resection (2010)

Aortic balloon occlusion decreases the total and intraoperative blood loss volumes in patients treated with sacral tumor surgery who require extensive dissection. There is a low rate of balloon-related complications.
Rapid identification of common chelants by anion-exchange thin layer chromatography (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRapid identification of common chelants by anion-exchange thin layer chromatographyEdward A. FitzgeraldCite this: Anal. Chem. 1975, 47, 2, 356–357Publication Date (Print):February 1, 1975Publication History Published online1 May 2002Published inissue 1 February 1975https://pubs.acs.org/doi/10.1021/ac60352a037https://doi.org/10.1021/ac60352a037research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Formulation and Evaluation of Sustained Release Dosage Form of Nifedipine Hydrochloride Using Hydrophilic Polymers (2013)

Sustained release oral delivery systems are designed to achieve therapeutically effective concentrations of drug in the systemic circulation over an extended period of time. The purpose of the present investigation was to design and evaluate sustained release matrix tablets of nifedipine, a poorly water soluble drug, employing hydroxypropyl methyl cellulose ( HPMC) and ethyl cellulose ( EC) as hydrophilic polymers. Direct compression method was used to prepare matrix tablets. Drug content uniformity, friability test were performed and the in vitro drug release profiles were compared with the innovator product ( Procardia ) benefiting similarity factor ( f2 ) and difference factor ( f1 ). In all formulations content uniformity was in the acceptable range. Most of the prepared formulations were passed friability test. Formulation containing HPMC and EC in the ratio of 88.5:5 showed acceptable dissolution properties compared to reference formulation. Fitting the release data to the kinetic models indicated that the best fitted kinetic model for the prepared matrix tablets and Procardia were zero order and Weibull model, respectively. This study indicates that the hydrophilic matrix tablets of nifedipine prepared using HPMC and EC can successfully be employed as sustained release matrix tablet in order to improve patient compliance.
Focal plane position detection with a diffractive optic for Shack–Hartmann wave-front sensor fabrication (2001)

During construction of a Shack-Hartmann wave-front sensor it is critical that the spacing between the lens array and the detector array be equal to the lens array focal length to obtain accurate and precise measurements of a wave front. This separation is often difficult to determine with large f/# lenses, because their focal spot diameter does not change substantially for small displacements on either side of the focal plane. We describe a method with an array of off-axis lens segments for determining the location of the focal plane. Because the lenses are off axis, changes in the distance from the optic to the detector array result in transverse focal spot position variations as a function of their separation from the lenses. By analyzing the focal spot pattern on a CCD, we achieved 12-mum rms error in the axial position measurement while moving a 4-mm-focal-length optic over 1 mm.
Seasonal Prediction of Sea Surface Temperature Anomalies Using a Suite of 13 Coupled Atmosphere–Ocean Models (2006)

Abstract Improved seasonal prediction of sea surface temperature (SST) anomalies over the global oceans is the theme of this paper. Using 13 state-of-the-art coupled global atmosphere–ocean models and 13 yr of seasonal forecasts, the performance of individual models, the ensemble mean, the bias-removed ensemble mean, and the Florida State University (FSU) superensemble are compared. A total of 23 400 seasonal forecasts based on 1-month lead times were available for this study. Evaluation metrics include both deterministic and probabilistic skill measures, such as verification of anomalies based on model and observed climatology, time series of specific climate indices, standard deterministic ensemble mean scores including anomaly correlations, root-mean-square (RMS) errors, and probabilistic skill measures such as equitable threat scores for seasonal SST forecasts. This study also illustrates the Niño-3.4 SST forecast skill for the equatorial Pacific Ocean and for the dipole index for the Indian Ocean. The relative skills of total SST fields and of the SST anomalies from the 13 coupled atmosphere–ocean models are presented. Comparisons of superensemble-based seasonal forecasts with recent studies on SST anomaly forecasts are also shown. Overall it is found that the multimodel superensemble forecasts are characterized by considerable RMS error reductions and increased accuracy in the spatial distribution of SST. Superensemble SST skill also persists for El Niño and La Niña forecasts since the large comparative skill of the superensemble is retained across such years. Real-time forecasts of seasonal sea surface temperature anomalies appear to be possible.
Sulfur Linkage in Vulcanized Rubbers (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfur Linkage in Vulcanized RubbersM. L. Selker and A. R. KempCite this: Ind. Eng. Chem. 1944, 36, 1, 16–28Publication Date (Print):January 1, 1944Publication History Published online1 May 2002Published inissue 1 January 1944https://pubs.acs.org/doi/10.1021/ie50409a004https://doi.org/10.1021/ie50409a004research-articleACS PublicationsRequest reuse permissionsArticle Views262Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A novel CVD-SiBCN Low-K spacer technology for high-speed applications (2008)

State-of-the-art low-K spacer technology featuring novel CVD-SiBCN material is demonstrated for the first time. A significant 20% CMOS ring speed enhancement is demonstrated with SiBCN (K=5.2) spacer, compared to Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> (K=7.5) spacer, due to reduced fringing capacitance and enhanced strain effects by spacer-PSS and CESL techniques. Electron mobility is improved by 6% for long channel NMOS transistor and g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m,max</sub> is increased by 11% for short 35 nm physical gate length NMOS using a preferable spacer structure that is comprised of a low stress SiBCN spacer on thin SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> liner and a final 600degC rapid thermal post-anneal. Superior GIDL and better gate leakage is obtained because low permittivity SiBCN alleviates gate-fringing field effects (GF effects), and device reliability is not adversely impacted by this new process.
Nonlithographic nanowire-array tunnel device: Fabrication, zero-bias anomalies, and Coulomb blockade (1998)

Coulomb blockade (CB) was observed in Al/aluminum oxide/Ni nanowire single-junction arrays fabricated by electrochemical deposition of Ni into porous aluminum oxide nanotemplates. The bias dependence of the tunneling current and the temperature dependence of the zero-bias anomalies observed in the tunneling spectra are shown to accord well with the theory of Nazarov for CB in systems where the leads play a significant role. Direct scanning tunneling microscopy measurements of the nanowire leads resistance confirms it to be the regime required by the theory.
Safety and Bactericidal Activity of Rifalazil in Patients with Pulmonary Tuberculosis (2001)

Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of approximately 60 h. Rifalazil has potent bactericidal activity against Mycobacterium tuberculosis in vitro and in animal models of tuberculosis (TB). Prior studies in healthy volunteers showed that once-weekly doses of 25 to 50 mg of rifalazil were well tolerated. In this randomized, open-label, active-controlled phase II clinical trial, 65 subjects with sputum smear-positive pulmonary TB received one of the following regimens for the first 2 weeks of therapy: 16 subjects received isoniazid (INH) (5 mg/kg of body weight) daily; 16 received INH (5 mg/kg) and rifampin (10 mg/kg) daily; 17 received INH (5 mg/kg) daily plus 10 mg of rifalazil once weekly; and 16 received INH (5 mg/kg) daily and 25 mg of rifalazil once weekly. All subjects were then put on 6 months of standard TB therapy. Pretreatment and day 15 sputum CFU of M. tuberculosis were measured to assess the bactericidal activity of each regimen. The number of drug-related adverse experiences was low and not significantly different among treatment arms. A transient decrease in absolute neutrophil count to less than 2,000 cells/mm(3) was detected in 10 to 20% of patients in the rifalazil- and rifampin-containing treatment arms without clinical consequences. Decreases in CFU counts were comparable among the four treatment arms; however, the CFU results were statistically inconclusive due to the variability in the control arms. Acquired drug resistance did not occur in any patient. Studies focused on determining a maximum tolerated dose will help elucidate the full anti-TB effect of rifalazil.
The Dopamine Theory of Attention Deficit Hyperactivity Disorder (ADHD) (1991)

Clinical, animal and neuroanatomical studies of differential isomer and dosage effects of CNS stimulant medications on behaviour are reviewed. Wender's hypothesis that an underlying biochemical abnormality and a disorder of reinforcement was the primary deficit in "MBD" children is restated in terms of a disorder of polysynaptic dopaminergic circuits, between prefrontal and striate centres. Wender's notion of a disorder of reinforcement is broadened to include a disorder of planning and correction of behaviour, including capacity for cortical control of automatic instinctual motor programmes. The dopamine hypothesis of Attention Deficit Hyperactivity Disorder (ADHD) is examined from the point of view of differential dose effects of CNS stimulant medications, and theories of neural control. Clinical, animal and neuropharmacological studies are reviewed. Implications of the findings for understanding clinical and side effects in ADHD children of stimulants are discussed.
Satellite-based entanglement distribution over 1200 kilometers (2017)

Long-distance entanglement distribution is essential for both foundational tests of quantum physics and scalable quantum networks. Owing to channel loss, however, the previously achieved distance was limited to ~100 kilometers. Here we demonstrate satellite-based distribution of entangled photon pairs to two locations separated by 1203 kilometers on Earth, through two satellite-to-ground downlinks with a summed length varying from 1600 to 2400 kilometers. We observed a survival of two-photon entanglement and a violation of Bell inequality by 2.37 ± 0.09 under strict Einstein locality conditions. The obtained effective link efficiency is orders of magnitude higher than that of the direct bidirectional transmission of the two photons through telecommunication fibers.
Detection of breast surgical margins with optical coherence tomography imaging: a concept evaluation study (2014)

This study aimed to evaluate the concept of using high-resolution optical coherence tomography (OCT) imaging to rapidly assess surgical specimens and determine if cancer positive margins were left behind in the surgical bed. A mouse model of breast cancer was used in this study. Surgical specimens from 30 animals were investigated with OCT and automated interpretation of the OCT images was performed and tested against histopathology findings. Specimens from 10 animals were used to build a training set of OCT images, while the remaining 20 specimens were used for a validation set of images. The validation study showed that automated interpretation of OCT images can differentiate tissue types and detect cancer positive margins with at least 81% sensitivity and 89% specificity. The findings of this pilot study suggest that OCT imaging of surgical specimens and automated interpretation of OCT data may enable in the future real-time feedback to the surgeon about margin status in patients with breast cancer, and potentially with other types of cancers. Currently, such feedback is not provided and if positive margins are left behind, patients have to undergo another surgical procedure. Therefore, this approach can have a potentially high impact on breast surgery outcome.
Evidence for Lipid Peroxidation in Obstructive Sleep Apnea (2004)

These results support the existence of an increased state of oxidative stress in OSA and its possible involvement in cardiovascular morbidity.
Comparison between different schemes for passivation of multicrystalline silicon solar cells by means of hydrogen plasma and front side oxidation (1993)

Different schemes for passivation of solar cells fabricated using casted multicrystalline silicon from Eurosolare are investigated. The efficiency of solar cells with front side oxide surface passivation, front side and/or back side hydrogen plasma passivation are compared. It is shown that oxide passivation of the front surface combined with hydrogen passivation from the back side is the optimum passivation scheme. A 16.2% top efficiency is obtained on 4 cm2 cells implementing this passivation scheme and a 16.8% top efficiency is estimated with an optimized ARC combination.
Safety of mirtazapine: a review (1995)

The clinical trial development programme of mirtazapine (Org 3770), performed in Europe and the United States, demonstrated an outstanding safety profile of this compound. The evaluation of the safety was based on data from all patients who took at least one dose of study medication during studies comparing mirtazapine with placebo, amitriptyline or other active comparators. A general indication of mirtazapine's safety is the significantly lower percentage of patients (65%) who complained of any adverse clinical experiences compared with the placebo- (76%) or amitriptyline-treated group (87%). Moreover, drop-out rates due to adverse clinical experiences were significantly lower than in the amitriptyline-treatment group. Mirtazapine has virtually no anticholinergic, adrenergic or typical selective serotonin reuptake inhibitor (SSRI) side effects. The only significantly higher incidences versus placebo were seen in the adverse clinical effects of drowsiness (23% versus 14%), excessive sedation (19% versus 5%), dry mouth (25% versus 16%), increased appetite (11% versus 2%) and weight increase (10% versus 1%). These complaints were typically mild and transient in nature, and decreased over time despite increased doses of mirtazapine. In contrast, significantly higher incidences of headache (5% versus 10%) and weight decrease (2% versus 6%), symptoms commonly seen in depressed patients, were recorded in the placebo-treated patients. Also, typical SSRI adverse events, such as nausea, vomiting, diarrhoea and insomnia, and symptoms of sexual dysfunction were registered less frequently in mirtazapine-treated patients than in the placebo-treated patients. Approximately 10% of the mirtazapine-treated patients in the clinical trial programme were older than 65 years. The pattern of adverse clinical experiences seen in this group of patients is fully in line with that seen in the overall patient population. The analysis of vital sign indices, i.e. blood pressure and heart rate, showed that no changes occurred with mirtazapine treatment; this pattern was fully comparable to that seen with placebo. Furthermore, very low incidences of clinically relevant changes in laboratory indices, such as the liver enzymes alanine aminotransferase and aspartate aminotransferase or neutropenia, were recorded in each treatment group. Mirtazapine has a very low seizure-inducing potential: only one case was recorded in a patient with a history of seizures during previous treatment with clomipramine. The low seizure-inducing potential combined with a lack of cardiotoxic properties allows safety in an overdose of mirtazapine, even in elderly patients. The only symptom seen in the patients taking an overdose of mirtazapine alone or in combination with other drugs was excessive but transient somnolence, which resolved spontaneously within a few hours. In conclusion, the new antidepressant mirtazapine offers clinicians a unique combination of strong efficacy and good safety.