gebhart/patrepeval huggingface dataset:
Ensembles of Neural Networks for Robust Reinforcement Learning (2010)

Reinforcement learning algorithms that employ neural networks as function approximators have proven to be powerful tools for solving optimal control problems. However, their training and the validation of final policies can be cumbersome as neural networks can suffer from problems like local minima or over fitting. When using iterative methods, such as neural fitted Q-iteration, the problem becomes even more pronounced since the network has to be trained multiple times and the training process in one iteration builds on the network trained in the previous iteration. Therefore errors can accumulate. In this paper we propose to use ensembles of networks to make the learning process more robust and produce near-optimal policies more reliably. We name various ways of combining single networks to an ensemble that results in a final ensemble policy and show the potential of the approach using a benchmark application. Our experiments indicate that majority voting is superior to Q-averaging and using heterogeneous ensembles (different network topologies) is advisable.
ChemInform Abstract: Probing the Acceptor Specificity of β‐1,4‐Galactosyltransferase for the Development of Enzymatic Synthesis of Novel Oligosaccharides. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Magnetoelastic effects in rare-earth iron-aluminum compounds (1993)

Magnetic and magnetoelastic measurements under various conditions of compressive stress and applied field have been carried out on samples with the composition Tb0.3Dy0.7(Fe1−xAlx)1.95, 0≤x≤0.1, prepared by a float-zone growth technique. Their magnetoelastic performances compare favorably with the highly magnetostrictive ‘‘Terfenol-D’’ compounds by having large magnetostrictive strains (λ∼1200 ppm at ∼120 kA/m), good magnetomechanical coupling (k33≊62%) and a large strain coefficient (d33≊80 nm/A). The substitution of aluminum for iron produces a material with potential benefits for use in actuators: higher electrical resistivity and improved ductility, which reduce eddy current effects and increase the mechanical strength.
CMM-Based Appraisal for Internal Process Improvement (CBA IPI): Method Description (2018)

This document is a high-level overview of the CMM-Based Appraisal for Internal Process Improvement (CBA IPI) V1.1 assessment method. It provides a brief history of SEI appraisal methods, as well as establishing appraisals in the context of the IDEAL approach to software process improvement. CBA IPI is a diagnostics, enables, and encourages an organization's commitment to process improvement. The method helps an organization gain insight into its software development capability by identifying strengths and weaknesses of its current processes related to the Capability Maturity Model for Software V1.1. The method focuses on identifying software improvements that are organization's business goals and current maturity level. Brief descriptions of the method activities, roles, and responsibilities are provided. In addition, guidelines are provided for establishing resource requirements for conducting a CBA IPI. The SEI Appraiser Program is discussed, detailing the requirements for persons qualified to lead CBA IPIs.
Vibration Behavior of a Helical Gear Pair under Light Load Condition : Experimental Verification of Meshing Properties (2002)

For the purpose of a detailed description of rotational vibration response of a helical gear pair having tooth surface deviation during light load transmission, we have already developed the numerical calculation method for gear vibration which can take any type of deviation into account. But there can be seen the tendency that the accuracy become worse when transmitting load is too low. Especially, gear pair's resonant frequency is too much influenced with transmitting torque comparing with the experimental results. To improve the accuracy of proposed simulation, we examine two types of tooth elastic deformation, tooth bending deformation and compressive deformation of tooth surfaces, precisely with vibration measurement and observation of contact pattern of meshing teeth.
Efficacy of abamectin against ectoparasites of cattle (1993)

Four trials, using 48 European breed cattle, were conducted to evaluate the efficacy of abamectin against the louse species Linognathus vituli, Haematopinus eurysternus and Damalinia bovis and against the mange mites Sarcoptes scabiei var bovis and Psoroptes ovis. Animals were allocated by restricted randomisation based on parasite counts to treatment with abamectin at a dose of 200 micrograms/kg given subcutaneously or to an untreated control group. Ectoparasites were counted before treatment and at weekly intervals thereafter for eight weeks. L. vituli, H eurysternus and S scabiei var bovis were eliminated (P < 0.05) by day 7 after abamectin treatment. An efficacy of more than 99 per cent was recorded against P ovis mange mites. The biting louse D bovis was not controlled. Abamectin treatment increased the weight gain of cattle infested with ectoparasites.
Magnetization dynamics of the ferrimagnet CoGd near the compensation of magnetization and angular momentum (2006)

Magnetization dynamics in alloys of ferrimagnetic CoGd have been studied in the vicinity of the magnetization and angular momentum compensation point as a function of alloy composition and temperature. In agreement with standard mean-field treatments of the dynamics of the total magnetization we observe an increase of the precessional frequency and the effective damping parameter near the angular momentum compensation point. We demonstrate the consistency of the magnetization dynamics extracted from frequency domain methods such as ferromagnetic resonance and time resolved laser pump-probe measurements.
Coupling of Amino Acids and Amino Sugars with Cyanuric Chloride (2,4,6-Trichloro-<i>s</i>-triazine) (1972)

2,4,6-Trichloro-s-triazine (cyanuric chloride) has been used to couple glycine ethyl ester with seven carbohydrate derivatives that contain amino groups. The reactions proceed in high yield under mild conditions. The compounds serve as models for the coupling of carbohydrates to proteins by well-defined linkages through amino groups.
Visualisation of material flow in autogenous friction stir welds (2000)

Material flow in friction stir welds has been visualised using embedded marker materials. The fidelity of the visualisation technique has also been demonstrated. Results from the flow visualisation show that the friction stir welding process can be roughly described as an in situ extrusion process wherein the tool shoulder, the weld backing plate, and the cold base metal outside the weld zone form an ‘extrusion chamber’ which moves relative to the workpiece. Deviation from this description occurs primarily at the top surface of the weld where significant material transport occurs owing to the action of the rotating tool shoulder. The transport caused by the shoulder leads to a small amount of circulation about the longitudinal axis of the weld with material moving primarily from trailing to leading sides at the top of the weld and primarily from leading to trailing near the middle and bottom of the weld.
Stimulation of <i>Streptococcus thermophilus</i> growth in mastitic milk (1984)

Growth of Streptococcus thermophilus was faster in mastitic milk, aseptically collected following intramammary infusion of Escherichia coli endotoxin, than in normal aseptically collected milk. The contribution of polymorphonuclear leucocytes (PMN), of plasma and plasmin to this stimulation has been investigated. Addition of plasmin to low cell count milk stimulated growth of the streptococcus to the same degree as mastitic milk. However, addition of plasma or PMN from blood or from milk were less stimulatory. The part played by these components in providing casein breakdown products for the weakly proteolytic Str. thermophilus in mastitic milk is discussed.
Mathematical Modeling of Steam-Assisted Gravity Drainage (2005)

Summary A mathematical model for gravity drainage in heavy-oil reservoirs and tar sands during steam injection in linear geometry is proposed. The mathematical model is based on the experimental observations that the steam-zone shape is an inverted triangle with the vertex fixed at the bottom production well. Both temperature and asphaltene content dependence on the viscosity of the drained heavy oil are considered. The developed model has been validated with experimental data presented in the literature. The heavy-oil production rate conforms well to previously published data covering a wide range of heavy oils and sands for gravity drainage.
Combination treatment in CTCL: the current role of bexarotene. (2012)

Primary cutaneous T-cell lymphomas are a heterogeneous group of extranodal NH lymphomas primarily presenting in the skin without extracutaneos involvement at diagnosis. Treatment choices closely depend on clinic-pathologic entity and disease stage. Among available choices, oral bexarotene has shown efficacy and safety both in monotherapy and in association with other treatments, by virtue of its versatility and high synergism with alpha-interferon, photochemotherapy (PUVA), and chemotherapy. Moreover, when associated with a wise management of its side effects, bexarotene is well tolerated if used in long-term administration, and it is therefore a good candidate to maintenance treatment after different induction therapies. Recently, the Gruppo Italiano Linfomi Cutanei (GILC) has started some pilot studies, with the aim to investigate bexarotene potential in association with PUVA and single agent chemotherapy (as pegylated liposomal doxorubicin and gemcitabine), and as consolidation/maintenance treatment. The preliminary results of GILC pilot studies confirm the good tolerability and safety of low-intermediate dose bexarotene, and its potential synergism with PUVA and chemotherapy. In addition, its use in consolidation/maintenance has proven efficacy in improving overall response rate.
Automated serial extraction of DNA and RNA from biobanked tissue specimens (2013)

The technology described here enables the processing of many tissue samples simultaneously with a high quality product and a time and cost reduction for the user. This reduces the sample preparation bottleneck in cancer research. The open automation format also enables integration with upstream and downstream devices for automated sample quantitation or storage.
Visual echo cancellation in a projector-camera-whiteboard system (2005)

We propose to incorporate a whiteboard into a projector-camera system. The whiteboard serves as the writing surface (input) as well as the projecting surface (output). The ability to write and draw on top of computer-projected content opens up many new opportunities for real-time collaborations between people located on-site and remotely. Such applications inevitably require extracting handwritings from video images that contain both handwritings and the projected content. By analogy with echo cancellation in audio conferencing, we call this problem visual echo cancellation. This paper presents one approach to accomplish the task. Our visual echo cancellation algorithm estimates the incident light and derives the surface albedo based on both incident light and reflection. By estimating the albedo, we can extract the writings and recover their colors. Our approach includes two basic components of projector-camera systems: geometric calibration and color calibration. The first one solves the mapping between the position in the camera view and the position in the projector screen, while the second one solves the mapping between the actual color of the projected content and that seen by the camera.
Slice-aware 5G Dynamic Small Cells (2019)

Network Slicing has become one of the fundamental pillars of the fifth generation (5G) mobile and wireless communications systems, which promises integration of a plethora of new vertical industries with tailored network design. To this end, 3rd generation partnership project (3GPP) Release 15 has provided the basis of the network slicing support including radio access network (RAN). Nevertheless, for the realization of native end-to-end (E2E) network slicing, further features and optimizations shall still be introduced. This paper places the focus on enabling network slicing operation in small cell deployments. In particular, the flexible network deployment capitalizing on unplanned dynamic small cells (DSCs) is analyzed, and the associated slice-aware operation is highlighted. Under the light of evaluations, key design recommendations are provided. In addition, architectural enhancements are discussed along with the required signaling procedures to support such slice-aware DSC operation.
The structure and segmentation of the Southeast Indian Ridge (1999)

The Southeast Indian Ridge (SEIR) spreads at a relatively narrow range of intermediate rates (59–75 km/Ma) but exhibits the full range of slow to fast spreading morphology and segmentation. Satellite gravity data reveal transitions in the structure of the spreading center where it is influenced by the Amsterdam and Kerguelen hotspots and at the Australian–Antarctic Discordance (AAD). Although the spreading rate between the hotspots and the AAD is nearly constant, the ridge exhibits a variety of distinct styles of morphology and segmentation not observed at fast or slow spreading centers. Recently, collected multibeam bathymetry data reveal a transition from East Pacific Rise style overlapping axial highs near 92°E to Mid-Atlantic Ridge style axial valleys with non-transform offsets near 116°E. The intervening segmentation is characterized by propagating offsets coexisting with stationary transforms which exhibit different degrees of temporal stability. Currently, there are 10 transform offsets between the hotspots and the AAD but only five of these have persisted since seafloor spreading stabilized at 35 Ma. The other five appear to have formed since 35 Ma and several more have disappeared by transform shortening or coalesced by along-axis propagation. There is a transition from monotonic offset propagation near the hotspots to oscillatory propagation approaching the AAD. This change in offset stability corresponds to transitions in depth, axial morphology and offset structure. Through much of the transitional region, higher order segmentation is characterized by en-echelon offsets of a diffuse spreading axis that generally lacks a well defined neovolcanic zone. Since the spreading rate is nearly constant, the regional variation in axial morphology and segmentation appears to be controlled by an upper mantle thermal gradient — possibly a result of flux of asthenosphere from the hotspots to the AAD. This is consistent with the gradual increase in average ridge flank depths along this part of the plate boundary but segment scale changes in axial depth reveal spatio-temporal variability in the dynamic topography that are not preserved on older lithosphere. Intrasegment transitions in axial morphology and en-echelon offsets within first order segments suggest that local variations in mantle thermal structure introduce short-lived instabilities in higher order segmentation and dominate the short term evolution of the plate boundary.
Cellular and molecular mechanisms of TNF protection in septic peritonitis. (1997)

Requirement for endogenous TNF for survival of experimental septic peritonitis has been demonstrated in a mouse model of cecal ligation and puncture (CLP). Induction of endogenous TNF production before CLP or administration of TNF before or after CLP confered protection from death. Interaction of TNF with the p55TNF receptor, formation of fibrin deposits, and granulocyte function was necessary to survive CLP. The mast cell seems to be an important cell type to provide the TNF required for protection in this model.
Total ranch management: meeting ranch goals. (1988)

This material was digitized as part of a cooperative project between the Society for Range Management, the National Agricultural Library, and the University of Arizona Libraries.
Crystal structure refinement with<i>SHELXL</i> (2014)

The improvements in the crystal structure refinement program SHELXL have been closely coupled with the development and increasing importance of the CIF (Crystallographic Information Framework) format for validating and archiving crystal structures. An important simplification is that now only one file in CIF format (for convenience, referred to simply as `a CIF') containing embedded reflection data and SHELXL instructions is needed for a complete structure archive; the program SHREDCIF can be used to extract the .hkl and .ins files required for further refinement with SHELXL. Recent developments in SHELXL facilitate refinement against neutron diffraction data, the treatment of H atoms, the determination of absolute structure, the input of partial structure factors and the refinement of twinned and disordered structures. SHELXL is available free to academics for the Windows, Linux and Mac OS X operating systems, and is particularly suitable for multiple-core processors.
Pituitary-specific expression and glucocorticoid regulation of a proopiomelanocortin fusion gene in transgenic mice. (1988)

The product of a single gene encoding proopiomelanocortin (POMC) is differentially processed to produce corticotropin and alpha-melanotropin in anterior and intermediate pituitary cells, respectively. Hormonal control of POMC gene transcription and of corticotropin or alpha-melanotropin release is also tissue-specific; for example, glucocorticoids specifically inhibit anterior but not intermediate pituitary POMC transcription. Outside the pituitary gland, very low levels of POMC mRNAs are present in brain, testes, ovaries, and placenta. We have used transgenic mice to identify POMC 5' flanking sequences that are sufficient for tissue-specific expression and glucocorticoid regulation in anterior and intermediate pituitary cells. Three lines of transgenic mice were established, each carrying 50-75 copies (per cell) of a chimeric rPOMCneo gene constituted of rat POMC promoter sequences and of bacterial neomycin-resistance coding sequence. High levels of rPOMCneo transcripts were detected in pituitaries of mice from all three lineages. In situ hybridization revealed that the ratio of intermediate to anterior pituitary transcripts was similar for the transgene and endogenous POMC mRNA. rPOMCneo transcripts were not detected in any other tissue except at very low levels in the testes in two transgenic lines. Endogenous mouse POMC mRNA increased in response to depletion of plasma glucocorticoids (adrenalectomy) and decreased after glucocorticoid treatment; rPOMCneo transcripts were altered to the same extent by these treatments in all three lines. Intermediate pituitary and testicular rPOMCneo transgene expression was not altered by these treatments. Thus, no more than 769 base pairs of the rat POMC promoter are required for pituitary-specific expression and for specific glucocorticoid inhibition of the POMC gene in the anterior pituitary.
Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke (2009)

These results suggest that lesions cause state changes in the spontaneous functional architecture of the brain, and constrain behavioral output. Clinically, these results validate using FC for assessing the health of brain networks, with implications for prognosis and recovery from stroke, and underscore the importance of interhemispheric interactions.
Automatic tuning of the multiprogramming level in Sybase SQL Anywhere (2010)

This paper looks at the problem of automatically tuning the database server multiprogramming level to improve database server performance under varying workloads. We describe two tuning algorithms that were considered and how they performed under different workloads. We then present the hybrid approach that we have successfully implemented in SQL Anywhere 12. We found that the hybrid approach yielded better performance than each of the algorithms separately.
Towards the prioritization of system test cases (2013)

SUMMARY During software development, companies are frequently faced with lack of time and resources, which limits their ability to effectively complete testing efforts. This paper presents a system‐level, value‐driven approach to test case prioritization called the Prioritization of Requirements for Test (PORT). PORT involves analysing and assigning value to each requirement using the following four factors: requirements volatility, customer priority, implementation complexity, and fault proneness. System test cases are prioritized such that the test cases for requirements with higher priority are executed earlier during system test. PORT was applied to four student team projects as well as an industrial case study. The results show that PORT improves the rate of detection of severe failures over random prioritization. Additionally, the results indicate that customer priority was the most important contributor towards improved rate of failure detection. Copyright © 2013 John Wiley & Sons, Ltd.
Infantile Type of So-Called Neuronal Ceroid-Lipofuscinosis (1974)

Attention was recently drawn to a progressive encephalopathy with early amaurosis. The disease has its clinical onset at the age of 8-18 months with rapid psychomotor deterioration, ataxia, muscular hypotonia. In the 45 cases examined microcephaly and myoclonic jerks were other prominent features; convulsions were few or did not occur at all. In all patients the disease reached a burnt-out stage during the third year. After the age of 5 years all children had a permanent increased flexor tonus in all limbs and flexion contractures were common. The mean age of death was 7.6 years. Early extinction of ERG, typical ophthalmological findings, and EEG records rapidly approaching isoelectricity were additional features. The disease has an autosomal recessive mode of inheritance. A total of 52 cases are known in Finland. Histologically, an almost total destruction of cerebral and cerebellar neurons was observed. The surviving neurons and glial cells contained granular material which histochemically resembled lipofuscin but ultrastructurally differed from those in earlier reported patients with neuronal ceroid-lipofuscinosis. The cases observed seem to form a clearly separable infantile type of so-called neuronal ceroid-lipofuscinosis.
Structural Basis for the Interaction of Tubulin with Proteins and Drugs that Affect Microtubule Dynamics (2000)

The microtubule cytoskeleton is a highly regulated system. At different times in the cell cycle and positions within the organism, microtubules can be very stable or highly dynamic. Stability and dynamics are regulated by interaction with a large number of proteins that themselves may change at specific points in the cell cycle. Exogenous ligands can disrupt the normal processes by either increasing or decreasing microtubule stability and inhibiting their dynamic behavior. The recent determination of the structure of tubulin, the main component of microtubules, makes it possible now to begin to understand the details of these interactions. We review here the structure of the tubulin dimer, with particular regard to how proteins and drugs may bind and modulate microtubule dynamics.