gebhart/patrepeval huggingface dataset:
Acoustic pharyngometry: clinical and instrumental correlations in sleep disorders (2007)

Although not a standardized test, acoustic pharyngometry was proved to be a useful method both in the diagnosis and severity of obstructive sleep apnea, and in post-operative monitoring of upper airway surgery in patients with sleep disorders.
Ineffectiveness of Recombinant Interferon- serine Nasal Drops for Prophylaxis of Natural Colds (1989)

Two randomized, double-blind, placebo-controlled trials during early autumn of 1986 and 1987 evaluated the efficacy and tolerance of recombinant interferon-beta serine (rIFN-beta ser) nasal drops for prevention of natural rhinovirus colds. In 1986, 9 X 10(6) units of rIFN-beta ser (139 subjects) or placebo (157) were administered once daily except Sundays for 4 w. Rhinovirus colds occurred in 2.8% of rIFN-beta ser recipients and 6.0% of placebo recipients during the treatment period (52% reduction, P = .3). In 1987, 24 X 10(6) units of rIFN-beta ser (186) or placebo (197) were given daily for 25 consecutive days. Rhinovirus colds developed in 6.3% of rIFN-beta ser recipients and 5.3% of placebo recipients. In each study, illness frequency and number of days with subjective colds did not differ between the groups. Recipients of nasal drops of rIFN-beta ser at either dosage did not differ in tolerance from placebo recipients. The lack of both prophylactic efficacy and nasal toxicity are in contrast to prior observations with nasal sprays of rIFN-alpha 2b.
Convolutional Neural Networks for Soft-Matching N-Grams in Ad-hoc Search (2018)

This paper presents \textttConv-KNRM, a Convolutional Kernel-based Neural Ranking Model that models n-gram soft matches for ad-hoc search. Instead of exact matching query and document n-grams, \textttConv-KNRM uses Convolutional Neural Networks to represent n-grams of various lengths and soft matches them in a unified embedding space. The n-gram soft matches are then utilized by the kernel pooling and learning-to-rank layers to generate the final ranking score. \textttConv-KNRM can be learned end-to-end and fully optimized from user feedback. The learned model»s generalizability is investigated by testing how well it performs in a related domain with small amounts of training data. Experiments on English search logs, Chinese search logs, and TREC Web track tasks demonstrated consistent advantages of \textttConv-KNRM over prior neural IR methods and feature-based methods.
Piezoresistivity of polycrystalline p-type diamond films of various doping levels at different temperatures (1997)

The piezoresistivity of polycrystalline p-type diamond films has been studied. The films were grown by microwave plasma assisted chemical vapor deposition and in situ doped with different concentrations of boron. A four-point electrical measurement was performed to evaluate the film resistivity change upon straining in a four-point bending beam setup. Films were glued directly onto a stainless steel beam and the silicon substrates were selectively removed. A gauge factor (relative change of the resistivity divided by the elastic strain) of about 690 under 100 microstrains was obtained at room temperature for a film doped with 32 ppm boron. With increasing temperature and dopant concentration the gauge factor increases. The experimental results obtained are discussed.
Effects of human monoclonal antibody 216 on B‐progenitor acute lymphoblastic leukemia in vitro (2006)

This increased cytotoxicity with chemotherapy and the functional ability of mAb 216 to use multiple pathways to induce cell death identify mAb 216 as a potentially novel therapeutic tool in the treatment of B-progenitor ALL. Based on the results from this preclinical study, a Phase I clinical trial with mAb 216 for the treatment of patients with relapsed or refractory B-lineage ALL is ongoing.
Isolation of Bacillus subtilis in connection with bovine mastitis. (1986)

Bacillus subtilis has only seldom been associated with pathological conditions in mammals. As the organism is considered to be ubiquitous in the environment, care has to be taken not to put too much emphasis on the pathogenicity of the organism, even in cases where it is isolated in pure culture. Bacillus subtilis was isolated from 17 cases of bovine mastitis in which it was considered to be the etiological factor.
Global query optimization (1986)

In some recently proposed extensions to relational database systems as well as in deductive databases, a database system is presented with a collection of queries to process instead of just one. It is an interesting problem then, to come up with algorithms that process these queries together instead of one query at a time. We examine the problem of multiple (global) query optimization in this paper. A hierarchy of algorithms that can be used for global query optimization is exhibited and analyzed. These algorithms range from an arbitrary serial execution without any sharing of common results among the queries to an exhaustive search of all possible ways to process all queries.
Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent (2014)

Integrin-mediated migration of neutrophils to infected tissue sites is vital for pathogen clearance and therefore host survival. Although β2 integrins have been shown to mediate neutrophil transendothelial migration during systemic and local inflammation, relatively little information is available regarding neutrophil migration in sepsis beyond the endothelial cell layer. In this study, we report that integrin α3β1 (VLA-3; CD49c/CD29) is dramatically upregulated on neutrophils isolated from both human septic patients and in mouse models of sepsis. Compared with the α3β1 (low) granulocytes, α3β1 (high) cells from septic animals displayed hyperinflammatory phenotypes. Administration of a α3β1 blocking peptide and conditional deletion of α3 in granulocytes significantly reduced the number of extravasating neutrophils and improved survival in septic mice. In addition, expression of α3β1 on neutrophils was associated with Toll-like receptor-induced inflammatory responses and cytokine productions. Thus, our results show that α3β1 is a novel marker of tissue homing and hyperresponsive neutrophil subtypes in sepsis, and blocking of α3β1 may represent a new therapeutic approach in sepsis treatment.
Indocyanine green-enhanced fluorescence to assess bowel perfusion during laparoscopic colorectal resection (2015)

ICG-enhanced fluorescent angiography provides useful intraoperative information about the vascular perfusion during colorectal surgery and may lead to change the site of resection and/or anastomosis, possibly affecting the anastomotic leak rate. Larger further randomized prospective trials are needed to validate this new technique.
Antitumor effect of nuclear factor‐κB decoy transfer by mannose‐modified bubble lipoplex into macrophages in mouse malignant ascites (2014)

Patients with malignant ascites (MAs) display several symptoms, such as dyspnea, nausea, pain, and abdominal tenderness, resulting in a significant reduction in their quality of life. Tumor-associated macrophages (TAMs) play a crucial role in MA progression. Because TAMs have a tumor-promoting M2 phenotype, conversion of the M2 phenotypic function of TAMs would be promising for MA treatment. Nuclear factor-κB (NF-κB) is a master regulator of macrophage polarization. Here, we developed targeted transfer of a NF-κB decoy into TAMs by ultrasound (US)-responsive, mannose-modified liposome/NF-κB decoy complexes (Man-PEG bubble lipoplexes) in a mouse peritoneal dissemination model of Ehrlich ascites carcinoma. In addition, we investigated the effects of NF-κB decoy transfection into TAMs on MA progression and mouse survival rates. Intraperitoneal injection of Man-PEG bubble lipoplexes and US exposure transferred the NF-κB decoy into TAMs effectively. When the NF-κB decoy was delivered into TAMs by this method in the mouse peritoneal dissemination model, mRNA expression of the Th2 cytokine interleukin (IL)-10 in TAMs was decreased significantly. In contrast, mRNA levels of Th1 cytokines (IL-12, tumor necrosis factor-α, and IL-6) were increased significantly. Moreover, the expression level of vascular endothelial growth factor in ascites was suppressed significantly, and peritoneal angiogenesis showed a reduction. Furthermore, NF-κB decoy transfer into TAMs significantly decreased the ascitic volume and number of Ehrlich ascites carcinoma cells in ascites, and prolonged mouse survival. In conclusion, we transferred a NF-κB decoy efficiently by Man-PEG bubble lipoplexes with US exposure into TAMs, which may be a novel approach for MA treatment.
Gene Disruption Study Reveals a Nonredundant Role for TRIM21/Ro52 in NF-κB-Dependent Cytokine Expression in Fibroblasts (2009)

The tripartite motif (TRIM) family member, TRIM21, is an E3 ubiquitin ligase for IFN regulatory factor (IRF)3 and IRF8 that functions in both innate and acquired immunity. It is also an autoantigen known as Ro52/SS-A. The function of TRIM21 in vivo, however, has remained elusive. We generated Trim21(-/-) mice with the Trim21 gene replaced by an enhanced GFP (EGFP) reporter. EGFP expression analyses showed that Trim21 was widely expressed in many tissues, with the highest levels in immune cells. Studies of Trim21(-/-) embryonic fibroblasts demonstrated that TLR-mediated induction of proinflammatory cytokines, including IL-1beta, IL-6, TNF-alpha, and CXCL10, was consistently up-regulated relative to wild-type cells. Reporter analyses demonstrated that TLR-mediated NF-kappaB activation was higher in Trim21(-/-) cells than in wild-type cells, most likely accounting for their enhanced cytokine expression. In contrast, functional analyses of immune cells from Trim21(-/-) mice revealed no abnormalities in their composition or function, even though ubiquitylation of IRF3 and IRF8 was impaired. These results suggested possible redundancies in activities mediated by TRIM21. In keeping with this concept, we found that a number of TRIM family members were up-regulated in Trim21(-/-) cells. Taken together, these findings demonstrate that TRIM21 plays a previously unrecognized role in the negative regulation of NF-kappaB-dependent proinflammatory cytokine responses, and suggest that multiple TRIM proteins contribute to the maintenance of functional equilibrium in inflammatory responses, in part through functional redundancy.
How Automation Can Help Broadcasters and Production Companies Reach Video Production Nirvana (2015)

The global TV & video industry is experiencing disruption and evolution with the rapid growth of video streaming services like Netflix and Amazon. ABI Research forecasts that live linear OTT video services will grow to approximately $7 billion dollars of worldwide revenue by 2021, from a little more than $1 billion in 2016. How is this trend impacting production studios and content creators? — To engage their audience and drive viewership, Netflix promised to double content production and Amazon committed to tripling the number of its original shows. The uptick will continue with some predicting that 2017 output could reach more than 500 scripted shows. Consequently, it will be a steep, new challenge for content producers, broadcasters and VOD service providers to keep pace with increasing demands. Some say this massive increase in programming — coined “peak TV” in some parts of the world—is unsustainable and producers may simply run out of resources and bandwidth. Ultimately, content creators and distributors need creative solutions to address the current surge in demand with lean resources. — This report will discuss the importance of eliminating silos of production through tight integrations across the ecosystem, and introducing production automation to eliminate manual tasks, shorten production cycles and increase productivity. These recommendations will include global examples from broadcasters and production companies who were facing some of these industry challenges. — It's all in effort to meet the TV demands of tomorrow.
Traumatic brain injury impairs synaptic plasticity in hippocampus in rats. (2011)

TBI leads to the impairment of hippocampus synaptic plasticity due to the changing of interneuronal interaction. The injury-induced disruption of synaptic efficacy within the hippocampal circuit may underlie the observed cognitive deficits and symptomatic epilepsy.
Mobile-oriented multimedia sharing system with multi-activity support (2012)

With the fast development of powerful mobile devices, people are having a better experience of accessing the Internet than ever before. Uploading and sharing words, photos and videos to the Internet has become a daily need for most people. Various apps on mobile devices have emerged on this area. However, different mobile OSs may distract developers from the UI design of the app itself. Meanwhile, different OSs usually implies different audio & video codec specifications. Not only do they have to consider the server-side development in compatibility with different OSs, but also they need to figure out the video compatibility issue for video sharing apps across multiple mobile OSs. Thus, we designed and implemented a mobile-oriented multimedia sharing system with multi-activity support, so as to help mobile app developers out of such worries.
Einstein-Podolsky-Rosen-correlated atomic ensembles (1999)

A method for generating two entangled macroscopic ensembles of atoms via interaction with Einstein-Podolsky-Rosen-correlated light is proposed. The method is directly applicable for creating entanglement between, e.g., two distant atom traps. The proposed special type of partial entanglement is analyzed.
Longitudinal movement of radioiodinated albumin within extravascular spaces of peripheral nerves following three systems of experimental trauma. (1967)

Radioiodinated serum albumin leaks with ease into the endoneurial spaces of chicken nerves following experimental lesions (Mellick and Cavanagh, 1967a). The subsequent fate of this protein is, at the moment, ill understood, particularly since there are no lymphatics in the endoneurial space
Purification and characterization of oxalate oxidase from Pseudomonas sp. OX-53. (1988)

Oxalate oxidase (EC 1.2.3.4) was purified to apparent homogeneity from Pseudomonas sp. OX53. The molecular weight of the enzyme was about 320, 000 by Sephadex G-200 column chromatography and 38, 000 by sodium dodecyl sulfate disc electrophoresis. The isoelectric point of the enzyme was pH 4.7 by isoelectric focusing. This enzyme contained 1.12 atoms of manganese and 0.36 atoms of zinc per subunit. Besides oxalic acid, the enzyme oxidized glyoxylic acid and malic acid at lower reaction rates. The Michaelis constant of the enzyme was 9.5mM for oxalic acid at the optimal pH 4.8. The enzyme was stable from pH 5.5 to 7.0. The enzyme was activated by flavins, phenylhydrazine, and o-phenylenediamine, and inhibited by I-, Br-, semicarbazide, and hydroxylamine.
Fibromatosis Colli in Infants (2003)

A confirmatory, noninvasive diagnosis of fibromatosis colli can be made by fine needle aspiration cytology alone; invasive diagnostic and therapeutic measures are best avoided. Excision biopsy may not be necessary and should be reserved for cases with a strong clinicopathologic suspicion of malignancy.
Global/Local Hashed Perceptron Branch Prediction (2008)

This paper introduces combining local history hashing and global history hashing in perceptron branch prediction. The proposed perceptron predictor utilizes self-history as well as global history in indexing different weights of a perceptron. The simulation results show that our proposed perceptron predictor is more accurate than the one using either global history hashing or local history hashing alone. Our proposed perceptron predictor improves the misprediction rate by up to 26.9% over path-based neural predictor, and 17.2% over hashed perceptron predictor. A reducing aliasing approach is employed to improve the accuracy of our proposed perceptron predictor by diminishing the impact of destructive interference, supported by the simulation results.
SnSe2 quantum dot sensitized solar cells prepared employing molecular metal chalcogenide as precursors (2012)

A kind of molecular metal chalcogenide, (N(2)H(4))(3)(N(2)H(5))(4)Sn(2)Se(6) complex, was synthesized in the hydrazine solution and employed as the precursors for SnSe(2) deposition on TiO(2) nanocrystalline porous films. A power conversion efficiency of 0.12% under AM 1.5, 1 sun was obtained for the SnSe(2) sensitized TiO(2) solar cells.
Adaptive Clutter-Aware Visualization for Mobile Data Stream Mining (2010)

There is an emerging focus on real-time data stream analysis on mobile devices. A wide range of data stream processing applications are targeted to run on mobile handheld devices with limited computational capabilities such as patient monitoring, driver monitoring, providing real-time analysis and visualization for emergency and disaster management, real-time optimization for courier pick-up and delivery etc. There are many challenges in visualization of the analysis/data stream mining results on a mobile device. These include coping with the small screen real-estate and effective presentation of highly dynamic and real-time analysis. This paper proposes a generic theory for visualization on small screens that we term Adaptive Clutter Reduction ACR. Based on ACR, we have developed and experimentally validated a novel data stream clustering result visualization technique that we term Clutter-Aware Clustering Visualizer (CACV). Experimental results on both synthetic and real datasets using the Google Andriod platform are presented proving the effectiveness of the proposed techniques.
Symmetric cone monotone functions and symmetric cone convex functions (2016)

Symmetric cone (SC) monotone functions and SC-convex functions are real scalar valued functions which induce Lowner operators associated with a simple Eu- clidean Jordan algebra to preserve the monotone order and convex order, respectively. In this paper, for a general simple Euclidean Jordan algebra except for octonion case, we show that the SC-monotonicity (respectively, SC-convexity) of order r is implied by the matrix monotonicity (respectively, matrix convexity) of some
Asymmetric Catalytic Aminoalkylations: New Powerful Methods for the Enantioselective Synthesis of Amino Acid Derivatives, Mannich Bases, and Homoallylic Amines (1999)

Modern methodologies such as the design of chiral catalysts using combinatorial techniques play a key role in the development of asymmetric aminoalkylations. Thus, powerful enantioselective syntheses for many attractive target compounds using chiral Lewis acid or base catalysts like 1 or 2 were created.
Comparing IPL2 and Yahoo! Answers: A Case Study of Digital Reference and Community Based Question Answering (2014)

In this paper, we took IPL2 and Yahoo! Answers as the two samples for our case study of digital references and community-based Q&A sites. We examined the services of the two systems based on 200 real questions raised in IPL2 and their similar questions found in Yahoo! Answers. Question type, topic classification, answer type, and answer time delay were compared between the similar questions in these two platforms. The result analysis showed that the two systems classify their questions differently, and the types of the questions asked are different too. It took much longer time to obtain answers from IPL2, whereas different types of questions in Yahoo! Answers generated dramatically different response time. However, some differences also demonstrated that there is need to consider integrating certain ideas in the two systems.
Preventive and Therapeutic Role of Functional Ingredients of Barley Grass for Chronic Diseases in Human Beings (2018)

Barley grass powder is the best functional food that provides nutrition and eliminates toxins from cells in human beings; however, its functional ingredients have played an important role as health benefit. In order to better cognize the preventive and therapeutic role of barley grass for chronic diseases, we carried out the systematic strategies for functional ingredients of barley grass, based on the comprehensive databases, especially the PubMed, Baidu, ISI Web of Science, and CNKI, between 2008 and 2017. Barley grass is rich in functional ingredients, such as gamma-aminobutyric acid (GABA), flavonoids, saponarin, lutonarin, superoxide dismutase (SOD), K, Ca, Se, tryptophan, chlorophyll, vitamins (A, B1, C, and E), dietary fiber, polysaccharide, alkaloid, metallothioneins, and polyphenols. Barley grass promotes sleep; has antidiabetic effect; regulates blood pressure; enhances immunity; protects liver; has anti-acne/detoxifying and antidepressant effects; improves gastrointestinal function; has anticancer, anti-inflammatory, antioxidant, hypolipidemic, and antigout effects; reduces hyperuricemia; prevents hypoxia, cardiovascular diseases, fatigue, and constipation; alleviates atopic dermatitis; is a calcium supplement; improves cognition; and so on. These results support that barley grass may be one of the best functional foods for preventive chronic diseases and the best raw material of modern diet structure in promoting the development of large health industry and further reveal that GABA, flavonoids, SOD, K-Ca, vitamins, and tryptophan mechanism of barley grass have preventive and therapeutic role for chronic diseases. This paper can be used as a scientific evidence for developing functional foods and novel drugs for barley grass for preventive chronic diseases.
Systematic Analysis of MicroRNAs Targeting the Androgen Receptor in Prostate Cancer Cells (2011)

Androgen receptor (AR) is expressed in all stages of prostate cancer progression, including in castration-resistant tumors. Eliminating AR function continues to represent a focus of therapeutic investigation, but AR regulatory mechanisms remain poorly understood. To systematically characterize mechanisms involving microRNAs (miRNAs), we conducted a gain-of function screen of 1129 miRNA molecules in a panel of human prostate cancer cell lines and quantified changes in AR protein content using protein lysate microarrays. In this way, we defined 71 unique miRNAs that influenced the level of AR in human prostate cancer cells. RNA sequencing data revealed that the 3'UTR of AR (and other genes) is much longer than currently used in miRNA target prediction programs. Our own analyses predicted that most of the miRNA regulation of AR would target an extended 6 kb 3'UTR. 3'UTR-binding assays validated 13 miRNAs that are able to regulate this long AR 3'UTR (miR-135b, miR-185, miR-297, miR-299-3p, miR-34a, miR-34c, miR-371-3p, miR-421, miR-449a, miR-449b, miR-634, miR-654-5p, and miR-9). Fifteen AR downregulating miRNAs decreased androgen-induced proliferation of prostate cancer cells. In particular, analysis of clinical prostate cancers confirmed a negative correlation of miR-34a and miR-34c expression with AR levels. Our findings establish that miRNAs interacting with the long 3'UTR of the AR gene are important regulators of AR protein levels, with implications for developing new therapeutic strategies to inhibit AR function and androgen-dependent cell growth.