gebhart/patrepeval huggingface dataset:
Management of Epstein-Barr Virus infections and post-transplant lymphoproliferative disorders in patients after allogeneic hematopoietic stem cell transplantation: Sixth European Conference on Infections in Leukemia (ECIL-6) guidelines (2016)

Epstein-Barr virus-related post-transplant lymphoproliferative disorders are recognized as a significant cause of morbidity and mortality in patients undergoing hematopoietic stem cell transplantation. To better define current understanding of post-transplant lymphoproliferative disorders in stem cell transplant patients, and to improve its diagnosis and management, a working group of the Sixth European Conference on Infections in Leukemia 2015 reviewed the literature, graded the available quality of evidence, and developed evidence-based recommendations for diagnosis, prevention, prophylaxis and therapy of post-transplant lymphoproliferative disorders exclusively in the stem cell transplant setting. The key elements in diagnosis include non-invasive and invasive methods. The former are based on quantitative viral load measurement and imaging with positron emission tomography; the latter with tissue biopsy for histopathology and detection of Epstein-Barr virus. The diagnosis of post-transplant lymphoproliferative disorder can be established on a proven or probable level. Therapeutic strategies include prophylaxis, preemptive therapy and targeted therapy. Rituximab, reduction of immunosuppression and Epstein-Barr virus-specific cytotoxic T-cell therapy are recommended as first-line therapy, whilst unselected donor lymphocyte infusions or chemotherapy are options as second-line therapy; other methods including antiviral drugs are discouraged.
X-ray Structures of the Dictyostelium discoideumMyosin Motor Domain with Six Non-nucleotide Analogs (2000)

The three-dimensional structures of the truncated myosin head from Dictyostelium discoideum myosin II complexed with dinitrophenylaminoethyl-, dinitrophenylaminopropyl-, o-nitrophenylaminoethyl-, m-nitrophenylaminoethyl-, p-nitrophenylaminoethyl-, and o-nitrophenyl-N-methyl-aminoethyl-diphosphate.beryllium fluoride have been determined to better than 2.3-A resolution. The structure of the protein and nucleotide binding pocket in these complexes is very similar to that of S1dC.ADP.BeF(x) (Fisher, A. J., Smith, C. A., Thoden, J., Smith, R., Sutoh, K., Holden, H. M., and Rayment, I. (1995) Biochemistry 34, 8960-8972). The position of the triphosphate-like moiety is essentially identical in all complexes. Furthermore, the alkyl-amino group plays the same role as the ribose by linking the triphosphate to the adenine binding pocket; however, none of the phenyl groups lie in the same position as adenine in S1dC.MgADP.BeF(x), even though several of these nucleotide analogs are functionally equivalent to ATP. Rather the former location of adenine is occupied by water in the nanolog complexes, and the phenyl groups are organized in a manner that attempts to optimize their hydrogen bonding interactions with this constellation of solvent molecules. A comparison of the kinetic and structural properties of the nanologs relative to ATP suggests that the ability of a substrate to sustain tension and to generate movement correlates with a well defined interaction with the active site water structure observed in S1dC.MgADP.BeF(x).
Differentiation of capillary leak and hydrostatic pulmonary edema with a macromolecular MR imaging contrast agent. (1991)

The ability of a macromolecular contrast agent (polylysine-[gadopentetate dimeglumine]40) to allow distinction of pulmonary capillary leak from hydrostatic pulmonary edema was investigated. Capillary leak edema was induced in 12 rats by means of venous injection of oleic acid; hydrostatic pulmonary edema was induced in 10 rats by means of continuous infusion of 0.9% sodium chloride. In the oleic acid pulmonary edema model, the signal intensity continued to increase for 12 minutes after administration of contrast material, indicating a leak of paramagnetic molecules from the intravascular to the extravascular spaces. Conversely, lung enhancement remained virtually constant after injection of contrast material in the hydrostatic edema model, as would be expected in the absence of endothelial damage. Hydrostatic edema tended to be distributed homogeneously throughout the lung, while capillary leak edema tended to occur predominantly in the peripheral portions of the lung. These findings indicate that macromolecular contrast agents can facilitate differentiation between edema caused by elevated intravascular pressure and edema induced by abnormal capillary permeability.
Maintenance of plasmids pBR322 and pUC8 in nonculturable Escherichia coli in the marine environment (1990)

Maintenance of plasmids pBR322 and pUC8 in Escherichia coli that was nonculturable after exposure to seawater was studied. E. coli JM83 and JM101, which contained plasmids pBR322 and pUC8, respectively, were placed in sterile artificial seawater for 21 days. Culturability was determined by plating on both nonselective and selective agar, and plasmid maintenance was monitored by direct isolation of plasmid nucleic acid from bacteria collected on Sterivex filters. E. coli JM83 became nonculturable after incubation for 6 days in seawater yet maintained plasmid pBR322 for the entire period of the study, i.e., 21 days. E. coli JM101 was nonculturable after incubation in seawater for 21 days and also maintained plasmid pUC8 throughout the duration of the microcosm experiment. Direct counts of bacterial cells did not change significantly during exposure to seawater, even though plate counts yielded no viable (i.e., platable) cells. We concluded that E. coli cells are capable of maintaining high-copy-number plasmids, even when no longer culturable, after exposure to the estuarine or marine environment.
Detection of Proteins in Serum by Micromagnetic Aptamer PCR (MAP) Technology (2009)

On the MAP: The title technique combines microfluidic magnetic sample preparation with highly specific aptamer-based molecular recognition and quantitative PCR. Using platelet-derived growth factor as a model, a fM detection limit was obtained in fetal bovine serum with a dynamic range that spanned five orders of magnitude.
A study of fast, robust stereo-matching algorithms (2010)

Stereo matching is an actively researched topic in computer vision. The goal is to recover quantitative depth information from a set of input images, based on the vi-sual disparity between corresponding points. This thesis investigates several fast and robust techniques for the task. First, multiple stereo pairs with different baselines may be meaningfully combined to improve the accuracy of depth estimates. In multi-baseline stereo, individual pairwise similarity measures are aggregated into a single evaluation function. We propose the novel product-of-error-correlation function as an effective example of this aggregate function. By imposing a common variable, inverse distance, across all stereo pairs, the correct values are reinforced while false matches are eliminated. Next, in a two-view stereo context, the depth estimates may also be made more robust by accounting for foreshortening effects. We propose an algorithm that allows a matching window to locally deform according to the surface orientation of the imaged point. The algorithm then performs correlation in multiple dimensions to simultaneously determine the most probable depth and tilt. The 2D surface ori-
Bilateral Thoracoscopic Splanchnicectomy in Patients with Chronic Pancreatitis (1999)

Background: Intractable pain, the most prominent feature of chronic pancreatitis, causes the patient great disability, and its treatment poses a difficult problem for gastroenterologist and surgeon alike. The main goal of treatment is to provide sufficient and lasting pain relief without the use of opiates. Conservative management, including stopping alcohol consumption, dietary measures, pancreatic enzyme suppletion and analgesics, is discussed. When these measures fail, surgery is often unavoidable. Indications, effect on pain relief, morbidity and mortality of drainage and resection procedures are described. Bilateral thoracoscopic splanchnicectomy, a newly developed operation to alleviate pain irrespective of the type of anatomic abnormality, is outlined in more detail. Early encouraging results of pain relief in patients with chronic pancreatitis after thoracoscopic splanchnicectomy are presented.
Generation of an acoustically bright zone with an illuminated region using multiple sources (2002)

This article addresses the way in which we can generate an "acoustically bright zone" in a space. The bright zone is defined as the volume where we can have higher acoustic energy than in other space. A method is proposed to generate the bright zone by controlling multiple monopole sources. Two kinds of cost functions involved with acoustic brightness are defined. One is the ratio of the brightness of a zone to the input power, and the other expresses the "contrast" between the bright zone and the other space. Through eigenvalue analysis, the optimal volume velocity distribution of the monopoles has been obtained.
Non-steroidal anti-inflammatory drugs and peptic ulcers. (1990)

Long term follow up studies for one to four years have not shown any tolerance to the efficacy of the drug or any long term side effects (E H Reynolds et al, 18th epilepsy international congress, New Delhi, 1989).21-23 Vigilance for possible long term toxicity should continue because early studies of toxicity in rats and dogs showed that microvacuoles suggestive of intramyelinic oedema were reversibly formed in the white matter in a dose related manner.2425 In dogs microvacuolation was accompanied by changes in the transmission time through the central nervous system of somatosensory evoked potentials, but such changes have not been observed in patients receiving long term treatment.2627 No evidence of intramyelinic oedema has been seen in six necropsies and 23 biopsy specimens taken from patients treated with vigabatrin for a mean of 25 months (D Scholey et al, Merrell Dow files, personal communication).
Waste management units - Savannah River Site (1989)

This report is a compilation of worksheets from the waste management units of Savannah River Plant. Information is presented on the following: Solid Waste Management Units having received hazardous waste or hazardous constituents with a known release to the environment; Solid Waste Management Units having received hazardous waste or hazardous constituents with no known release to the environment; Solid Waste Management Units having received no hazardous waste or hazardous constituents; Waste Management Units having received source; and special nuclear, or byproduct material only.
The unusual red giants in M5, M10 and M92. (1973)

Dispersants used in oil spills could result toxic to marine organisms and could influence the toxicity of oil compounds. The aim of this work was to uncover the mechanisms of action of the water accommodated fraction (WAF) of a naphthenic North Sea crude oil produced at 10, 15 and 20 °C without and with the dispersant Finasol OSR52 (WAF and WAFD, respectively) using hemocytes of the marine mussel Mytilus galloprovincialis. Primary cultures of hemocytes were exposed in glass-coated microplates to different WAF or WAFD dilutions (0.25, 2.5, 25, 50 and 100%) and to the dispersant alone at the same concentrations present in the WAFD dilutions (1.25, 12.5, 125, 250 and 500 mg/L). Of the two in vitro approaches tested, the second one was selected which involved exposure of hemocytes for 4 h to unfiltered WAF, WAFD and dispersant dilutions without cell culture media. WAF decreased hemocytes viability only at the highest dilution whereas WAFD and the dispersant alone were cytotoxic at the three highest concentrations. Temperature of production of WAF, WAFD and dispersant did not influence their cytotoxicity to hemocytes. WAF increased ROS production and MXR transport activity in hemocytes. Exposure to WAFD and dispersant increased ROS production, provoked plasma membrane and actin cytoskeleton disruption and decreased phagocytic activity. In conclusion, the dispersant tested was toxic to mussel hemocytes and it greatly increased the toxicity of WAFD. The present data could be useful for the environmental risk assessment of oil spills and their remediation strategies in the marine environment.
RF-based guard light management system by using Wireless Sensor Network technologies (2011)

This paper presents a Guard Light Flasher Unit to which the wireless communication technology of 447 MHz bandwidth as well as the Pseudo-3-Way-Handshake routing algorithm for reliable communication in an outdoor environment is applied. We describe how to design, develop and apply some effective routing protocol technologies for communication to the real environment in a city center.
Reasoning by hypothesizing causal models (2002)

The authors present some aspects of a reasoner that can handle uncertain knowledge and that hypothesizes causal models to explain the observed evidence. Such reasoning is useful where the objective of the reasoner is either to pursue an investigation or to construct a desired type of argument. The authors present the intuitive properties that may be displayed by a causal model and formalise them in the context of the hypergraph structure that is used for representing the causal knowledge. They use probability inferences made in the context of each causal model as a basis for preferring one causal model over the other. They use an algorithm based on A* search to construct efficiently those models which derive preferred probabilistic inferences.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
It feels better than filing (2009)

Activity-based computing represents an alternative to the dominant application- and document-centric model at the foundation of most mainstream desktop computing interfaces. In this paper, we present in-depth results from an in situ, longitudinal study of an activity-based computing system, Giornata. We detail the ways that the specific features of this system influenced the everyday work experiences of a small cohort of knowledge workers. Our analysis provides contributions at several levels of granularity-we provide concrete design recommendations based on participants' reactions to the particular features of the Giornata system and a discussion about how our findings can provide insight about the broader understanding of knowledge work and activity within HCI.
Proteomic Comparison of Two-Dimensional Gel Electrophoresis Profiles from Human Lung Squamous Carcinoma and Normal Bronchial Epithelial Tissues (2003)

Differential proteome profiles of human lung squamous carcinoma tissue compared to paired tumor-adjacent normal bronchial epithelial tissue were established and analyzed by means of immobilized pH gradient-based two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) and matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). The results showed that well-resolved, reproducible 2-DE patterns of human lung squamous carcinoma and adjacent normal bronchial epithelial tissues were obtained under the condition of 0.75-mg protein-load. The average deviation of spot position was 0.733+/-0.101 mm in IEF direction, and 0.925+/-0.207 mm in SDS-PAGE direction. For tumor tissue, a total of 1241+/-88 spots were detected, 987+/-65 spots were matched with an average matching rate of 79.5%. For control, a total of 1190+/-72 spots were detected, and 875+/-48 spots were matched with an average matching rate of 73.5%. A total of 864+/-34 spots were matched between tumors and controls. Forty-three differential proteins were characterized: some proteins were related to oncogenes, and others involved in the regulation of cell cycle and signal transduction. It is suggested that the differential proteomic approach is valuable for mass identification of differentially expressed proteins involved in lung carcinogenesis. These data will be used to establish human lung cancer proteome database to further study human lung squamous carcinoma.
Intravenous Cytokine Gene Delivery by Lipid-DNA Complexes Controls the Growth of Established Lung Metastases (1999)

Local expression of cytokine genes by ex vivo transfection or intratumoral gene delivery can control the growth of cutaneous tumors. However, control of tumor metastases by conventional nonviral gene therapy approaches is more difficult. Intravenous injection of lipid-DNA complexes containing noncoding plasmid DNA can significantly inhibit the growth of early metastatic lung tumors. Therefore, we hypothesized that delivery of a cytokine gene by lipid-plasmid DNA complexes could induce even greater antitumor activity in mice with established lung metastases. The effectiveness of treatment with lipid-DNA complexes containing the IL-2 or IL-12 gene was compared with the effectiveness of treatment with complexes containing noncoding (empty vector) DNA. Treatment effects were evaluated in mice with either early (day 3) or late (day 6) established lung tumors. Lung tumor burdens and local intrapulmonary immune responses were assessed. Treatment with either noncoding plasmid DNA or with the IL-2 or IL-12 gene significantly inhibited the growth of early tumors. However, only treatment with the IL-2 or IL-12 gene induced a significant reduction in lung tumor burden in mice with more advanced metastases. Furthermore, the reduction in tumor burden was substantially greater than that achieved by treatment with recombinant cytokines. Treatment with the IL-2 or IL-12 gene was accompanied by increased numbers of NK cells and CD8+ T cells within lung tissues, increased cytotoxic activity, and increased local production of IFN-gamma by lung tissues, compared with treatment with noncoding DNA. Thus, cytokine gene delivery to the lungs by means of intravenously administered lipid-DNA complexes may be an effective method of controlling lung tumor metastases.
Preparation, Characterization, and Photocatalytic Applications of MWCNTs/TiO<sub>2</sub>Composite (2014)

The multiwall carbon nanotubes (MWCNTs)/titanium dioxide (P25) composite in different ratios was prepared using simple evaporation and drying process. The composite was characterized by Raman spectroscopy, X - ray diffraction (XRD), UV - visible diffuse reflectance spectroscopy, and scanning electron microscopy (SEM). The photocatalytic activity of this composite was investigated using degradation of the Bismarck brown R dye (BBR). An optimal MWCNTs/TiO 2 ratio of 0.5% (w/w) was found to achieve the maximum rate of BBR degradation. It was observed that the composite exhibits enhanced photocatalytic activity compared with TiO 2 . The enhancement in photocatalytic activity performance of the MWCNTs/P25 composite is explained in terms of recombination of photogenerated electron-hole pairs. In addition, MWCNTs act as a dispersing support to control the morphology of TiO 2 particles in the MWCNTs/TiO 2 composite.
Paediatric antiretroviral pharmacology (2005)

Half of the ARV agents available worldwide have paediatric 
approval, but many are without ideal paediatric formulations. 
Pharmacokinetic differences in paediatric populations require 
careful attention to dosing and concomitant therapies. 
Importantly, ARV therapy can be limited by short-term and 
long-term toxicity and drug interactions. Low-cost, sustained and consistent access to ARV therapy is 
necessary to combat the HIV epidemic. For optimal response 
g 90 - 95% adherence to ARVs is required. This requires that 
extensive education and support resources be provided in 
addition to the ARV medications themselves. Paediatric 
patients receiving ARV therapy require ongoing monitoring to 
ensure tolerability, dose adjustments with advancing age, 
acceptability and therapeutic success.
Ultrasonically Induced Degradation and Detoxification of Microcystin-LR (Cyanobacterial Toxin) (2005)

Cyanobacterial toxins (CBTs), produced by glue-green algae, are one of the most common naturally occurring toxins found in potable waters. The microcystin family of CBTs present in drinking water sources poses a considerable threat to human health. In this study, we have demonstrated that ultrasonic irradiation at 640 kHz leads to rapid degradation of microcystin-LR (MC-LR). Degradation of MC-LR present in the crude cyanobacterial extracts containing cell constituents has been studied with ultrasound under a variety of conditions. The degradation of MC-LR was demonstrated over a concentration range from 0.03 to 3.0 microM. Hydroxyl radical scavenger experiments indicate that hydroxyl radical is responsible for a significant fraction of the observed degradation, but other processes (hydrolysis/ pyrolysis) are also important. Analysis of the protein phosphatase inhibition activity of the reaction products indicates that the products from ultrasonic degradation of MC-LR do not exhibit any measurable biological activity. The results demonstrate that ultrasonic irradiation maybe an effective and practical method for the detoxification of microcystins from drinking water.
A simplified HPLC method for the determination of phytoestrogens in soybean and its processed products (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA simplified HPLC method for the determination of phytoestrogens in soybean and its processed productsGuangjian Wang, Shia S. Kuan, Octave J. Francis, George M. Ware, and Allen S. CarmanCite this: J. Agric. Food Chem. 1990, 38, 1, 185–190Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/jf00091a041https://doi.org/10.1021/jf00091a041research-articleACS PublicationsRequest reuse permissionsArticle Views1127Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts