gebhart/patrepeval huggingface dataset:
Integrated 2-D Interpretation of Resistivity Logging Measurements by Inversion Methods (1995)

Abstract The determination of residual and movable hydrocarbons in oil and gas reservoirs requires that the formation resistivities are accurately estimated. For this purpose the log analyst can use several resistivity measurements with different measuring principles providing varying vertical and radial resolutions. Integrating these measurements into a uniform algorithm mat solves for the formation resistivities can improve the interpretation. Conventional interpretation methods of electromagnetic measurements use approximate and independent techniques for laterolog and induction logging measurements. These techniques do not necessarily provide the same results for the parameter estimates. Using a joint inversion algorithm that simultaneously solves for all measurements provides an earth model consistent with all measurements. In audition, the ability to resolve is enhanced due to the fact that galvanic and induction tools have different response characteristics in conductive or resistive formations. The laterolog is more sensitive to resistive formations; whereas, the induction tool is more sensitive to conductive formations. The combination of both measurements in a joint inversion process, therefore, increases the overall resolution. The inversion technique not only provides the formation parameter results, but gives the log analyst useful statistical information that can be used as quality control. In contrast with the standard interpretations, which are normally based on a 1-D interpretation, the 2-D inversion can simultaneously solve for a resistivity distribution in the radial and vertical directions. When the resistivity contrast is high, the shoulder bed effects can be very strong. This can be the case if a reservoir is delineated by conductive shales. The different vertical resolutions between deep induction and focussed log measurements appear as an offset between the two curves which could be interpreted as invasion. The 2-D inversion is able to distinguish between shoulder bed and invasion effects and provides more reliable results than a standard 1-D interpretation. Shoulder bed effects may result in underestimating the amount of oil in place if the reservoir is embedded in a conductive formation. The problem of delineating the reservoir and determining the vertical boundaries of the reservoir (and subsequently its thickness, which can be used together with the resistivity to estimate the total amount of hydrocarbon) can be solved using a 2-D inversion. This work demonstrates how the borehole, invasion and shoulder bed effects influence the data and subsequently the results of a standard interpretation. This is shown using synthetic and real field data.
Enantiospecific Synthesis of 1-Azafagomine (2000)

For the first time the two enantiomeric forms of the glycosidase inhibitor 1-azafagomine have been synthesised starting from D- and L-xylose. D-Xylose was converted to the 2,3,5-tribenzylfuranose, which upon reductive amination with tert-butyl carbazate gave the protected 1-hydrazino-1-deoxypentitol in high yield. N-acetylation, mesylation of the 4-OH, removal of the Boc group, cyclisation and deprotection gave (+)-1-azafagomine ((+)-1). By a similar sequence of reactions, L-xylose was converted to (-)-1-azafagomine ((-)-1). Enzymatic and other routes to optically pure 1-azafagomine were also studied. Compound (-)-1 is a potent competitive glycosidase inhibitor, while (+)-1 has no biological activity. The inhibition of almond beta-glucosidase by (-)-1 was found to be slow owing to a slow binding step of inhibitor to enzyme, with no subsequent conformational rearrangement. The rate constants for binding and release were found to be 3.3 x 10(4)M(-1)s(-1) and 0.011 s(-1), respectively, yielding Ki = 0.33 microM.
Rapid Open‐Air Digital Light 3D Printing of Thermoplastic Polymer (2019)

3D printing has witnessed a new era in which highly complexed customized products become reality. Realizing its ultimate potential requires simultaneous attainment of both printing speed and product versatility. Among various printing techniques, digital light processing (DLP) stands out in its high speed but is limited to intractable light curable thermosets. Thermoplastic polymers, despite their reprocessibility that allows more options for further manipulation, are restricted to intrinsically slow printing methods such as fused deposition modeling. Extending DLP to thermoplastics is highly desirable, but is challenging due to the need to reach rapid liquid-solid separation during the printing process. Here, a successful attempt at DLP printing of thermoplastic polymers is reported, realized by controlling two competing kinetic processes (polymerization and polymer dissolution) simultaneously occurring during printing. With a selected monomer, 4-acryloylmorpholine (ACMO), printing of thermoplastic 3D scaffolds is demonstrated, which can be further converted into various materials/devices utilizing its unique water-soluble characteristic. The ultralow viscosity of ACMO, along with surface oxygen inhibition, allows rapid liquid flow toward high-speed open-air printing. The process simplicity, enabling mechanism, and material versatility broaden the scope of 3D printing in constructing functional 3D devices including reconfigurable antenna, shape-shifting structures, and microfluidics.
Evidence of recombination and an antigenically diverse immunoglobulin A1 protease among strains of Streptococcus pneumoniae (1995)

The genetic relationships among 114 isolates of Streptococcus pneumoniae representing mainly nine serotypes that frequently cause severe childhood disease in Northern Europe were examined by use of multilocus enzyme electrophoresis. A comparison was made of the corresponding antigenic variations of excreted immunoglobulin A1 (IgA1) proteases detected by enzyme neutralization assays. Allelic variation at 13 gene loci among 70 electrophoretic types disclosed a comparatively low mean genetic diversity per locus (H = 0.319). In contrast, IgA1 proteases showed extensive antigenic diversity as 17 different inhibition types were distinguished. A lack of overall clonality was apparent from the linkage equilibrium of alleles harbored by 28 isolates chosen to represent the genetic diversity of the study population. However, certain clones, such as those marked by identical electrophoretic type, serotype, and IgA1 protease type, persisted for a sufficiently long time to enable clonal spread between distant geographic areas. Among clonally related isolates, examples illustrating a shift of capsular serotype or IgA1 protease type supported the view that recombination occurs in vivo in corresponding genes. In conclusion, over time, horizontal genetic exchange appears to be sufficiently frequent to disrupt the clonal structure otherwise generated by binary fission in natural populations of S. pneumoniae. The clonal instability combined with considerable antigenic heterogeneity renders the pneumococcal IgA1 protease less attractive as a potential component of future vaccines.
Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India (2006)

In a study of mainly paucibacillary leprosy-affected sib-pair families from South India, in addition to the expected associations with the HLA-DRB1 locus, we have identified significant association with a functional variant of the MICA gene as well as a microsatellite in the flanking region of the MICB gene. The associations with MICA and MICB cannot be accounted for by linkage disequilibrium with the HLA class II locus indicating a role in genetic susceptibility to leprosy that is independent of HLA-DRB1. Previous studies have shown that MICA and MICB are expressed on the surface of cells in response to infection, where they are recognized by the NKG2D receptor on gd T cells, CD81 ab T cells and natural killer cells, all of which contribute to defense against mycobacteria. The MICA * 5A5.1 allele, associated here with leprosy susceptibility, encodes a protein lacking a cytoplasmic tail providing a possible mechanism for defective immune surveillance against mycobacteria.
Furfural production needs chemical innovation (2000)

Current industrial processes yield only about half as much furfural as expected from analytical procedures. Why is this, and what must be done to boost industrial yields to the analytical level?
CXCR4–CCR5: A couple modulating T cell functions (2008)

Chemokines and their receptors direct leukocyte migration among blood, lymph and tissues. Evidence has recently accumulated that, besides their chemotactic functions, chemokine receptors are highly versatile players that fine tune immune responses. During human T cell activation by antigen-presenting cells, the chemokine receptors CCR5 and CXCR4 are recruited into the immunological synapse, where they deliver costimulatory signals. However, the molecular mechanisms allowing signaling versatility of chemokine receptors are unknown. Here, we describe the functional interaction between CXCR4 and CCR5 to exert specific biological functions and modulate T lymphocyte responses. We demonstrate that simultaneous expression and cooperation between CCR5 and CXCR4 are required for chemokine-induced T cell costimulation at the immunological synapse. In addition, we provide evidence for a physical association of the two receptors in a signaling complex that activates distinct T cell functions. We suggest that cooperation between receptors represents one key strategy for the functional plasticity of chemokines.
Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS (2001)

The loss of gray matter in the frontal regions (total ALS group) provides further support that ALS is a multisystem disorder. In addition, there is in vivo evidence of axonal degeneration in the subcortical white matter in the motor region in patients with bulbar-onset ALS. This is consistent with a "dying back" process affecting cortical motoneurons in bulbar-onset ALS.
Dextran sulphate: an adjuvant for cell-mediated immune responses. (1977)

The effect of high mol. wt dextran sulphate (DS) on cell-mediated immune responses was studied. Three criteria were used to assess cell-mediated delayed-type hypersensitivity: footpad swelling, i.d. skin tests and macrophage migration inhibitory factor (MIF) production. Guinea-pigs sensitized with egg albumin (EA) and treated with DS showed strong positive delayed skin tests. Control animals given only EA showed negative skin tests. Lymphocytes from mice sensitized s.c. with EA and treated with DS showed an increase in MIF production. Delayed footpad swelling responses in mice sensitized s.c. with sheep red blood cells (SRBC) and treated with DS were increased when the mice were challenged 8 days after sensitization. Doses of DS which were effective in increasing delayed footpad swelling ranged from 50-200 mg DS/kg body weight. DS was only capable of increasing delayed footpad swelling responses when both SRBC and DS were injected s.c. at the same site. Intraperitoneal injection of both SRBC and DS obeebction of both s.c. but at different sites did not result in increased delayed footpad swelling. DS was capable of augmenting footpad swelling responses when given s.c. as much as 6 days before SRBC. The optimal time for administration of DS was 2 days before SRBC. Injection of DS 2 days or more after SRBC resulted in no increase in delayed footpad swelling responses. The results of this study indicate that dextran sulphate is a potent adjuvant for cell-mediated delayed-type hypersensitivity immune responses in both mice and guinea-pigs.
Radioiodine I-131 for the therapy of graves' disease. (2009)

Graves' disease is a common cause of hyperthyroidism. Treatment options for Graves' disease include antithyroid medication, surgery or radioactive iodine (I-31) or RAI. This review will focus on the approach to RAI therapy; discussing dose selection, patient preparation, and consideration before and after administering RAI, examining aspects of pre-treatment with antithyroid medication as well as discussing possible adverse events including hypothyroidism and possible worsening of thyroid-associated opthalmopathy. Follow-up is lifelong with the aim of ensuring the patient remains euthyroid or on replacement therapy if there is evidence of hypothyroidism. While there are controversies in treatment of thyrotoxicosis with RAI, with appropriate patient selection and regular follow-up, radioiodine is a safe and effective modality in achieving high cure rates.
Aromatic Isocyanates as Reagents for the Identification of Some Heterocyclic Compounds (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAromatic Isocyanates as Reagents for the Identification of Some Heterocyclic CompoundsRonald A. Henry and William M. DehnCite this: J. Am. Chem. Soc. 1949, 71, 7, 2297–2300Publication Date (Print):July 1, 1949Publication History Published online1 May 2002Published inissue 1 July 1949https://pubs.acs.org/doi/10.1021/ja01175a008https://doi.org/10.1021/ja01175a008research-articleACS PublicationsRequest reuse permissionsArticle Views538Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
R&D of cable compounds abroad (2001)

This article presents the tendency of development and application in stablizer, flame retardant, curing agent and base polymer abroad an indicates that in order to adapt itself to the changing market at home and aborad, China should make researches into and take counter measures for cable compound production as soon as possible.
Highly efficient editing of the β-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease (2019)

Sickle cell disease (SCD) is a monogenic disorder that affects millions worldwide. Allogeneic hematopoietic stem cell transplantation is the only available cure. Here, we demonstrate the use of CRISPR/Cas9 and a short single-stranded oligonucleotide template to correct the sickle mutation in the β-globin gene in hematopoietic stem and progenitor cells (HSPCs) from peripheral blood or bone marrow of patients with SCD, with 24.5 ± 7.6% efficiency without selection. Erythrocytes derived from gene-edited cells showed a marked reduction of sickle cells, with the level of normal hemoglobin (HbA) increased to 25.3 ± 13.9%. Gene-corrected SCD HSPCs retained the ability to engraft when transplanted into non-obese diabetic (NOD)-SCID-gamma (NSG) mice with detectable levels of gene correction 16-19 weeks post-transplantation. We show that, by using a high-fidelity SpyCas9 that maintained the same level of on-target gene modification, the off-target effects including chromosomal rearrangements were significantly reduced. Taken together, our results demonstrate efficient gene correction of the sickle mutation in both peripheral blood and bone marrow-derived SCD HSPCs, a significant reduction in sickling of red blood cells, engraftment of gene-edited SCD HSPCs in vivo and the importance of reducing off-target effects; all are essential for moving genome editing based SCD treatment into clinical practice.
Suicide in Schizophrenics, Manics, Depressives, and Surgical Controls (1978)

This article reports suicide risk among 200 schizophrenic, 100 manic, and 225 depressive patients, and 160 surgical controls. The suicide experience of the study subjects was compared to that of the population of the state of Iowa, the geographical area and population from which the subjects were selected. The suicide experience of the surgical controls was not significantly different from that of the general population. On the other hand, increased risk of suicide was found in all psychiatric groups except female schizophrenics. Suicide appeared pronounced particularly in male patients with affective disorders during the first decade of the follow-up period.
SIFs of rectangular tensile sheets with symmetric double edge defects (2010)

Tensile sheets with symmetrically placed cracks on opposite edges are studied using the displacement discontinuity method with crack-tip elements.Three cases are considered: a rectangular sheet, one with half-circle indentations on the cracked edges, and one with notch indentations.Solutions for the stress intensity factors (SIFs) of the three problems are given, revealing the effect of the geometric parameters.By comparing the three cases, one observes that the indentations have a shielding effect.
MicroRNA-199a-3p Is Downregulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration (2011)

microRNAs (miRNA, miR) play an important role in cancer cell growth and migration; however, the potential roles of miRNAs in osteosarcoma remain largely uncharacterized. By applying a miRNA microarray platform and unsupervised hierarchical clustering analysis, we found that several miRNAs have altered expression levels in osteosarcoma cell lines and tumor tissues when compared with normal human osteoblasts. Three miRNAs, miR-199a-3p, miR-127-3p, and miR-376c, were significantly decreased in osteosarcoma cell lines, whereas miR-151-3p and miR-191 were increased in osteosarcoma cell lines in comparison with osteoblasts. Transfection of precursor miR-199a-3p into osteosarcoma cell lines significantly decreased cell growth and migration, thus indicating that the inhibition effect is associated with an increase in the G(1)-phase and a decrease of the S-phase cell population. In addition, we observed decreased mTOR and Stat3 expression in miR-199a-3p transfected cells. This study provides new insights for miRNAs in osteosarcoma and suggests that miR-199a-3p may play a functional role in osteosarcoma cell growth and proliferation. Restoring miR-199a-3p's function may provide therapeutic benefits in osteosarcoma.
New Method of Generation of Carbon Molecules and Clusters (2013)

Firstly the method of joint synthesis of carbon molecules and their hydrides is developed. The stage of high-temperature sublimation of carbon in a new method of generation of carbon molecules is completely excluded. By mass spectrometric method the condensation products of new method of pyrolysis (NMP) benzene are studied. Firstly clusters (C3-C17), typical for carbon vapour, in substances obtained under pyrolysis of hydrocarbons were detected. Fullerene C60 and its hydrides, quasi-fullerenes C48 and C33 inproducts of benzene pyrolysis are detected also. Firstly it is shown what clusters C3-C5 can be generated at so low (100?C-200?C) temperatures of decomposition of substance. Obtained experimental results firstly demonstrate that the small carbon molecules can be generated in reactionary conditions excluding evaporation of carbon. Dehydrogenation and destruction of hydrocarbon molecules is the first stage on a route of the transformation of benzene to carbon molecules.
Treatment of Squamous Cell Carcinoma with Interferon (1991)

Human natural leukocytic interferon and recombinant HulFN alpha 2c can be used in the therapy of squamous cell carcinoma. The duration of treatment was 3-6 weeks. A single dose was 400,000-5,000,000 units given weekly for 3-6 weeks. Clinically and histologically 19 of 32 patients were cured and tumor cells were not found in the material taken after interferon treatment for the second biopsy. In ten patients tumor size was reduced 25-90%, and in three patients tumor size was not reduced according to clinical findings. With recombinant HulFN alpha 2c therapy given 5 times per week for 4 weeks. Four of ten patients with similar tumors were cured clinically and histologically clinical findings. In five patients tumor size was reduced 25-90%, while in one patient there was no reduction in tumor size. Both types of interferons are effective in the treatment of squamous cell carcinoma. Side reactions were mild.
Transmit/Receive‐antenna diversity techniques for OFDM systems (2002)

Abstract In this paper, we investigate different antenna diversity concepts, which can be easily applied to orthogonal frequency division multiplexing (OFDM) systems. The focus is on standard compatibility, i.e. these schemes can be implemented to already existing OFDM systems without changing the standards. The introduced diversity techniques are applied exemplarily to the DVB‐T system. Bit error performance investigations were done by simulation for different DVB‐T and diversity parameter sets.
A nonparametric nonstationary procedure for failure prediction (2002)

The time between failures is a very useful measurement to analyze reliability models for time-dependent systems. In many cases, the failure-generation process is assumed to be stationary, even though the process changes its statistics as time elapses. This paper presents a new estimation procedure for the probabilities of failures; it is based on estimating time-between-failures. The main characteristics of this procedure are that no probability distribution function is assumed for the failure process, and that the failure process is not assumed to be stationary. The model classifies the failures in Q different types, and estimates the probability of each type of failure s-independently from the others. This method does not use histogram techniques to estimate the probabilities of occurrence of each failure-type; rather it estimates the probabilities directly from the values of the time-instants at which the failures occur. The method assumes quasistationarity only in the interval of time between the last 2 occurrences of the same failure-type. An inherent characteristic of this method is that it assigns different sizes for the time-windows used to estimate the probabilities of each failure-type. For the failure-types with low probability, the estimator uses wide windows, while for those with high probability the estimator uses narrow windows. As an example, the model is applied to software reliability data.
The Assessment of Sex in Cremated Individuals: Some Cautionary Notes (2002)

Identification of cremated bodies is problematic due to the effect of burning on the tissues of the body. Since hard tissues are altered by burning, it is likely that identification techniques that rely on these tissues will also be affected. The purpose of this study is to examine how heat-induced changes in the hard tissues of the body influence the results of anthropological methods of analysis. Twelve sheep Os coxae were burned in a fire-brick furnace. Eight measurements were taken from the sheep Os coxae before ànd after burning. Heat-induced shrinkage was calculated as a percentage. The significance of the differences between the measurements taken before and after burning was assessed statistically (Wilcoxon Signed Rank). The alternative hypothesis, that the difference was significant, was accepted. The influence of heat-induced shrinkage on sex assessment techniques was examined algebraically, then demonstrated with metric methods of sex assessment. The conclusion reached was that uniform shrinkage of the pelvis would not affect metric sex determination techniques, but that differential shrinkage of the variables that comprise the metric sex assessment technique can result in misclassification of male cremated pelves as female, and vice versa.