gebhart/patrepeval huggingface dataset:
Localization of a mobile robot by matching 3D-laser-range-images and predicted sensor images (2005)

This article describes a system for localization of a mobile robot. Position and orientation of the vehicle are determined by extracting vertical surfaces from a 3D-laser-range-image, which are matched with surfaces predicted from an environmental model. The use of predicted sensor images accelerates the segmentation and matching processes by focussing on regions of interest. The three main components 3D-laser-range-camera, environmental model and the localization algorithm are presented in detail. Quantitative results for localization in laboratory and manufacturing environments proved accuracy, robustness and real-time capability of this localization system.
RP-hPLC/ESI MS determination of acyl chain positions in phospholipids (2002)

Since phospholipids are used as excipients in many pharmaceutical products, there is a need for validated strategies to characterize the phospholipid constituents. We describe a reversed phase HPLC/electrospray ionization mass spectrometry method that is an alternative to the laborious phospholipase A2 treatment commonly used to determine the acyl chain positions in phospholipids. This reversed phase HPLC/electrospray mass spectrometry system (a) shows good chromatographic resolution for phosphatidylcholine molecular species, (b) allows determination of the composition of complex mixtures of phosphatidylcholines, and, most important, (c) allows unequivocal assignment of the positions of the acyl chains on the glycerol backbone in mixtures of POPC and OPPC and in mixtures of POPE and OPPE.
Novel colon targeted drug delivery system using natural polymers (2008)

A novel colon targeted tablet formulation was developed using pectin as carrier and diltiazem HCl and indomethacin as model drugs. The tablets were coated with inulin followed by shellac and were evaluated for average weight, hardness and coat thickness. In vitro release studies for prepared tablets were carried out for 2 h in pH 1.2 HCl buffer, 3 h in pH 7.4 phosphate buffer and 6 h in simulated colonic fluid. The drug release from the coated systems was monitored using UV/Vis spectroscopy. In vitro studies revealed that the tablets coated with inulin and shellac have limited the drug release in stomach and small intestinal environment and released maximum amount of drug in the colonic environment. The study revealed that polysaccharides as carriers and inulin and shellac as a coating material can be used effectively for colon targeting of both water soluble and insoluble drugs.
Night-Time Ground Hyperspectral Imaging for Urban-Scale Remote Sensing of Ambient PM. I. Aerosol Optical Thickness Acquisition (2012)

Aerosol loadings in vertical atmospheric columns are commonly measured by satellite-borne or ground instruments that remotely sense the spectral extinction through the optical path. However, correlations of these integrated measurements with ground-level particulate matter concentrations are highly influenced by local meteorology, seasonality, and the surface albedo. Moreover, as most measurements are based on solar radiation, they are limited to daytime. To account for these limitations, we study the feasibility of using a ground hyperspectral camera for acquiring images of artificial light sources through horizontal urban-scale open paths during the night, in order to retrieve the apparent spectral aerosol optical thickness. Laboratory-scale measurements demonstrated a linear response of the camera and set the spectral operational range. A procedure for night-time imaging of illuminating targets through ambient open paths has been developed to enable a consistent selection of pixels for analysis, providing measurable apparent aerosol optical thickness. We demonstrate the validity of this procedure by field acquisition of hyperspectral signatures through different arid and rural open paths in the Negev desert, Israel. An open path of 180 m provided a test case for imaging during clear and stable ambient conditions, from which an inherent measurement error of ∼4% was estimated. Imaging through a very long open path indicated an uppermost open path limit of about 4 km, resulting from a significant attenuation of the sensor's spectral response. Imaging and aerosol optical thickness retrieval under common environmental conditions through urban-scale open paths of about 1 km in Haifa is also demonstrated. Copyright 2012 American Association for Aerosol Research
Promoter hypermethylation of fibulin 1 gene is associated with tumor progression in hepatocellular carcinoma (2011)

Hepatocellular carcinoma (HCC) is one of the most common cancers world-wide but the molecular mechanisms that underlie hepatocarcinogenesis are not fully determined. On the same surgical sample with HCC, we performed microarray-based gene expression profiling and karyotype analysis using a single nucleotide polymorphism (SNP) array. In addition, quantitative real-time reverse transcription polymerase chain reaction (PCR), methylation specific PCR (MSP) and immunohistochemical staining were conducted using specimens from 48 patients with HCC. Gene expression profiling showed the expression of fibulin 1 (FBLN1), located on 22q13, to be decreased in tumor tissue. Karyotype analysis revealed no loss of heterozygosity (LOH) since deletions were not detected in 22q, and one of the SNPs on 22q13 showed AB genotype in both cancerous tissue and in corresponding noncancerous tissue, indicating retention of heterozygosity. Quantitative real-time PCR showed FBLN1 mRNA levels in cancerous tissues to be significantly decreased compared with that in corresponding noncancerous tissues. The immunohistochemical staining results were consistent with both gene expression profiling and quantitative PCR data. Twenty-four out of 48 HCCs gave a positive result in MSP. Moreover, promoter hypermethylation of FBLN1 was significantly associated with advanced stage HCC, multiple tumors and increased tumor size. Our results indicated that FBLN1 is a novel candidate of tumor suppressor gene and that promoter hypermethylation of FBLN1 is associated with tumor progression in HCC. © 2011 Wiley-Liss, Inc.
On efficient multi-angle face prototype collection (2004)

Although extremely tedious, collecting multi-angle face prototypes is essential for face-related applications such as detection, tracking, recognition, and pose estimation. To reduce the loaad, we propose a user-friendl interface that is designed to collect multi-angle face prototypes in a fast and easily tractable manner. A user-friendly interface called dynamic cursor is designed to guide users' viewing directions for orientation-enforced video acquisition. A new problem called the orientation-enforced face detection problem is proposed and solved for multi-angle face prototype collection. Our method can help build a fast and user-friendly face registration module for face-related applications.
Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines. (1998)

In this study the in vitro antitumor activity of a series of 20 colchicine analogues was tested and compared with colchicine and thiocolchicine on three different human cancer cell lines, two of which express the multidrug-resistance (MDR) phenotype. At concentrations from 1 nM to 100 microM, all compounds tested inhibited cancer cell proliferation. The IC50 values indicate that the three fluorinated analogues were the most active compounds, with a similar decreasing order of potency (IDN 5005 > IDN 5079 > IDN 5080) on the two MDR-expressing cell lines, whereas thiocolchicine was the most effective compound on the MDR-negative MDA-MB 231 cells. A strong correlation (r = 0.94; P = 0.004) was found between IC50 values obtained using the two MDR-positive cell lines. Conversely, IC50 values obtained in MDA-MB 231 cells did not show a significant correlation with MDR-positive cell lines, thereby suggesting some difference in the antiproliferative mechanism(s) of colchicine analogues. Cell cycle analysis of the most active analogues in breast cancer cells showed a relationship between cell cycle blocking activity and growth inhibition. The most active agents on the MDR-positive MCF7 ADRr cell line, after 24 h of culture, in terms of cell cycle blocking activity were the three fluorinated analogues. Interestingly, after 72 h, when the cell cycle block subsided, a consistent amount of DNA fragmentation was evident. The extent of cell cycle block, measured as the G2/G1 ratio, was significantly correlated with the apoptosis rate expressed as a percentage of DNA fragmentation on both cell lines, thereby suggesting that a large number of blocked cells underwent the apoptotic pathway.
Quick audio retrieval using active search (2002)

This paper discusses a method to search quickly through broadcast audio data to detect and locate known sounds using reference templates, based on the active search algorithm and histogram modeling of zero-crossing features. Active search reduces the number of candidate matches between reference and test template by up to 36 times compared to exhaustive search, while still remaining optimal. Computation is further reduced by using computationally inexpensive zero-crossing features. The method is robust against white noise addition down to 20 dB signal-to-noise ratios and digitization noise.
Synthetic Experiments in the Ferrichrome Series<sup>*</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic Experiments in the Ferrichrome Series*Samuel Rogers and J. B. NeilandsCite this: Biochemistry 1964, 3, 12, 1850–1855Publication Date (Print):December 1, 1964Publication History Published online1 May 2002Published inissue 1 December 1964https://pubs.acs.org/doi/10.1021/bi00900a010https://doi.org/10.1021/bi00900a010research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE‐induced sprouting angiogenesis in vitro (2008)

Anti-VEGF treatment has become accepted first-line treatment for choroidal neovascularisation (CNV) in age-related macular degeneration. However, VEGF-inhibition does not always lead to sustained CNV-reduction. In this study, the effect of rapamycin was superior to VEGF-inhibition in a co-culture assay of endothelial cells (ECs) and retinal pigment epithelium (RPE). Rapamycin reduced EC sprouting in groups that did not respond to anti-VEGF treatment. Rapamycin did not induce EC apoptosis, but reduced both VEGF-production in RPE and the responsiveness of ECs to stimulation. Rapamycin might therefore be a therapeutic option for CNV patients that do not respond sufficiently to the established anti-VEGF treatments.
Hot topics in epigenetic mechanisms of aging: 2011 (2012)

Aging is a complex process that results in compromised biological functions of the organism and increased susceptibility to disease and death. Although the molecular basis of aging is currently being investigated in many experimental contexts, there is no consensus theory to fully explain the aging process. Epigenetic factors, including DNA methylation, histone modifications, and microRNA expression, may play central roles in controlling changes in gene expression and genomic instability during aging. In this Hot Topic review, we first examine the mechanisms by which these epigenetic factors contribute to aging in diverse eukaryotic species including experimental models of yeasts, worms, and mammals. In a second section, we will emphasize in the mammalian epigenetic alterations and how they may affect human longevity by altering stem cell function and/or somatic cell decline. The field of aging epigenetics is ripe with potential, but is still in its infancy, as new layers of complexity are emerging in the epigenetic network. As an example, we are only beginning to understand the relevance of non-coding genome to organism aging or the existence of an epigenetic memory with transgenerational inheritance. Addressing these topics will be fundamental for exploiting epigenetics phenomena as markers of aging-related diseases or as therapeutic targets.
Frequency doubling of Yb-doped fiber laser to 515 nm (2010)

Operation of Yb-doped fiber laser (YDFL) at short wavelengths (about 1030 nm) is known to be possible with relatively short active fibers. Frequency doubling of such a laser is studied. It is shown that, in contrast to conventional YDFLs, operating around 1080 nm, the short-wavelength YDFL does not exhibit significant spectral broadening induced by nonlinear effects. Thus, the generated spectrum remains narrower than the FBG reflection profile, which allows an almost twofold intracavity intensity enhancement. Consequently, the second harmonic generation in the KTP crystal placed inside the YDFL cavity appears more effective than the generation in the single-pass scheme by an order of magnitude. An output power of about 0.4 W at a wavelength of 515 nm is demonstrated.
Analysis of yeast retrotransposon Ty insertions at the CAN1 locus. (1989)

The target site distribution for 55 independent Ty insertions that inactivate the function of the Saccharomyces cerevisiae CAN1 gene is reported. Under some selection conditions Ty elements inserted preferentially into the promoter and exhibited an orientation bias. In contrast, under other conditions no insertions were detected in the promoter region and transposition appeared to occur randomly throughout the CAN1 coding sequence. These results show that the target site distribution for Ty insertions may be a function of the selection conditions.
Sensational spherical shells (1986)

Fluid-dynamic and capillary forces can be used to form nearly perfect, very small spherical shells when a liquid that can solidify is passed through an annular die to form an annular jet. Gravity and certain properties of even the most ideal materials, however, can cause slight asymmetries. The primary objective of the present work is the control of this shell formation process in earth laboratories rather than space microgravity, through the development of facilities and methods that minimize the deleterious effects of gravity, aerodynamic drag, and uncontrolled cooling. The spherical shells thus produced can be used in insulation, recyclable filter materials, fire retardants, explosives, heat transport slurries, shock-absorbing armor, and solid rocket motors.
Process definition for reuse asset management process for software detailed design (2013)

The software development life cycle consists of many steps, such as the planning stage, the design stage, the development stage etc. Each step produce assets that can be reused, based on the assets' context, which can help reduce the initial capital and the time needed to develop software systems. At the same time, it improves the quality and productivity. However this is not possible if the organization is lacking best practices. This research proposes a Reuse Asset Management Process, based on the standard of ISO/IEC 12207:2008 and practices of the IEEE 1517:2010 standard, which deals with the software detailed design process, to serve as a guideline for process management.
Plasma pharmacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous versus oral administration in a randomized, crossover trial. (1987)

Since cyclophosphamide is used by both oral and i.v. routes in the treatment of hematological and solid malignancies, we designed a randomized, crossover clinical trial to evaluate the pharmacokinetics of this anticancer agent after either administration route. Plasma levels of cyclophosphamide and its two cytotoxic metabolites, 4-hydroxycyclophosphamide and phosphoramide mustard, were determined in seven cancer patients randomly assigned to treatment initially with either orally or i.v. administered cyclophosphamide with a 30-day interim between alternate therapy courses. Oral treatment was used initially in five patients and i.v. treatment in two patients, and the pharmacokinetic parameter, area under the plasma disappearance curve, was determined for each metabolite in each patient for both routes of drug administration. Statistical comparison of area under the plasma disappearance curve values for this set of patients indicated no significant differences for either metabolite for oral versus i.v. drug treatment, suggesting equal efficacy for these two routes of cyclophosphamide administration.
Control of carbon nanotube growth directions and morphology by direct current plasma enhanced chemical vapor deposition (2006)

Vertical alignment of individual carbon nanotubes (CNTs) and CNT arrays during their growth has been demonstrated by many groups; however, there has been much less progress towards more complicated morphologies. In this work, I show the ability to use direct current plasma enhanced chemical vapor deposition to control the growth direction of CNTs. By careful engineering of the cathode geometry, the electric field directions within the cathode plasma sheath are controlled and the CNTs grow along these customized field lines. The ability to dramatically change the growth direction of CNTs and create sharp bends and zigzag structures is also demonstrated. A model for the electric fields within the plasma sheath and in the region of CNT growth is proposed. Using this model to assist in the experimental design of the electrode geometries, both the CNT growth directions and sharp bend angles can be predicted to within 2⁰. Additional morphology control over CNTs is also demonstrated including the ability to control the carbon capping to allow easy re-growth of CNTs, a method of opening the ends of aligned CNTs without using any wet chemical processing or oxidation step, the creating of multiple aligned branchings formed from a single CNT creating Y- or T- junctions of desired angles, and the creation of three dimensional structures such as coiled CNTs. The novel CNT morphologies created in this work could serve useful in a variety of applications and initial results are presented for their use as a catalyst particle support structure for potential fuel cell applications, field emission sources for flat panel display or projection e-beam lithography, improved probe tips for scanning probe microscopy, and templates for guided growth of nerve cells
DMT-based ADSL: concept, architecture, and performance (1994)

We present various aspects of a high performance ADSL transceiver system using the powerful discrete multitone (DMT) modulation technology. DMT is the adopted ADSL line code for the emerging North American (ANSI), as well as the European (ETSI), ADSL standard. We first introduce the basic concept of DMT modulation, which effectively divides the transmission channel into a number of parallel subchannels and allows optimal usage of each subchannel to achieve bandwidth-on-demand. We then address various implementational issues related to an ANSI standard compliant ADSL transceiver, including bit loading, channel coding, echo cancellation, and bit swapping. Finally, the performance, including both independent laboratory measurements of prototype ADSL systems and computer simulations, is presented.
Phoenix: Memory Speed HPC I/O with NVM (2016)

In order to bridge the gap between the applications' I/O needs on future exascale platforms, and thecapabilities of conventional memory and storage technologies, HPC system designs started integrating components based onemerging non-volatile memory technologies. Non-volatile memory (NVRAM) provides persistent storage at close to memoryspeeds, with good capacity scaling, leading to opportunitiesto accelerate I/O in exascale machines. However, naive use ofNVRAM devices with current software stacks, exposes newbottlenecks due to the limited device bandwidth and slowerdevice access times compared to DRAM. To address this, we propose Phoenix (PHX), an NVRAM-bandwidth aware object store for persistent objects. PHXachieves efficiency through use of memory-centric objectinterfaces and device access stack specialized for NVRAM. Furthermore, PHX deals with the limited PCM bandwidththrough simultaneous use of NVRAM and DRAM devices, thus increasing the effective data movement bandwidth. Thisleads to reduction in the time length of the critical path I/Ooperations associated with the slow NVM device. To continueguaranteeing adequate reliability for the persistent objects, DRAM-resident object state is replicated across peer nodes'memory, accessible through high-bandwidth interconnects. Furthermore PHX minimizes the data movement overheads dueto additional data copies, by using a cost model that considersdevice bandwidths, remote storage distance and energy costs. Experimental analysis using real-world HPC applications onemulated NVRAM hardware shows that Phoenix's controlleduse of node-local and remote-node memory bandwidth, delivers up to ~ 1.2×, ~ 2× and ~ 12× speed-up for checkpoint I/Ofor the S3D, CM1 and GTC HPC applications, respectively. Furthermore PHX reduces total simulation checkpoint over-head of GTC up to ~ 18%.
Viscous induced drag (1988)

A fundamentally new approach to the aircraft minimum induced drag problem is presented. The method, a 'viscous lifting line', is based on the minimum entropy production principle and does not require the planar wake assumption. An approximate, closed form solution is obtained and compared with several classical results. In addition, the problem of optimizing in-plane wing sweep with constant wing root bending moment is considered. Like the classical lifting line theory, this theory predicts that induced drag is proportional to the square of the lift coefficient and inversely proportional to the wing aspect ratio. Unlike the classical theory, it predicts that in-plane wing sweep may significantly reduce induced drag, that induced drag is Reynolds number dependent, and that the optimum spanwise circulation distribution is non-elliptic.
Design of a Non-linear Endomicroscope Biopsy Probe (2006)

This paper introduces nonlinear optical (NLO) endomicroscope for non-invasive tissue optical biopsy. This NLO endomicroscope is composed of micro-optical components including micro-prism, GRIN lens, multi-axis high speed scanning actuators integrated at proximal end of endoscope.