gebhart/patrepeval huggingface dataset:
Recruitment mechanisms of primary and malignant B cells to the human liver (2012)

Our findings demonstrate that distinct combinations of signals promote B-cell recruitment to the liver, suggesting the possibility of novel targets to modulate liver inflammation in disease. Certain features of lymphocyte homing are maintained in lymphoma recruitment to the liver, suggesting that therapeutic targets for lymphocyte recruitment may also prevent hepatic lymphoma dissemination.
The Differential Diagnosis of Posterior Plagiocephaly: True Lambdoid Synostosis versus Positional Molding (1996)

The diagnosis and treatment of posterior plagiocephaly is one of the most controversial aspects of craniofacial surgery. The features of true lambdoid synostosis versus those of deformational plagiocephaly secondary to positional molding are inadequately described in the literature and poorly understood. This has resulted in many infants in several craniofacial centers across the United States undergoing major intracranial procedures for non-synostotic plagiocephaly. The purpose of this study was to describe the detailed clinical, imaging, and operative features of true lambdoid synostosis and contrast them with the features of positional plagiocephaly. During a 4-year period from 1991 to 1994, 102 patients with posterior plagiocephaly were assessed in a large multidisciplinary craniofacial program. During the same period, 130 patients with craniosynostosis received surgical treatment. All patients were examined by a pediatric dysmorphologist, craniofacial surgeon, and pediatric neurosurgeon. Diagnostic imaging was performed where indicated. Patients diagnosed with lambdoid synostosis and severe and progressive positional molding underwent surgical correction using standard craniofacial techniques. Only 4 patients manifested the clinical, imaging, and operative features of unilambdoid synostosis, giving an incidence among all cases of craniosynostosis of 3.1 percent. Only 3 among the 98 patients with positional molding required surgical intervention. All the patients with unilambdoid synostosis had a thick ridge over the fused suture, identical to that found in other forms of craniosynostosis, with compensatory contralateral parietal and frontal bossing and an ipsilateral occipitomastoid bulge. The skull base had an ipsilateral inferior tilt, with a corresponding inferior and posterior displacement of the ipsilateral ear. These characteristics were completely opposite to the findings in the 98 patients who had positional molding with open lambdoid sutures and prove conclusively that true unilambdoid synostosis exists as a specific but rare entity. Awareness of the features of unilambdoid synostosis will allow more accurate diagnosis and appropriate treatment of posterior plagiocephaly in general and in particular will avoid unnecessary surgical intervention in patients with positional molding.
Design and Implementation of Self-confidence System under the Information Technology (2016)

In this paper, the basic principles of Marxist philosophy as the guiding ideology are based on information technology and information science. It combine the consciousness and self-confidence in theoretical philosophy with development of information technology, discusses the influence of the theory consciousness and self-confidence with the development of information technology, then investigate the new features, new elements and new mechanisms of the theory consciousness and self-confidence in the information society.
Audiologists' professional satisfaction. (1997)

This study was primarily designed to explore the job satisfaction of audiologists in the United States. A total of 285 audiologists completed background questions, rated statements, and answered questions about their job satisfaction. Through the use of multiple regression analyses, six statements were identified as being statistically significant in predicting job satisfaction. The most important factor was in the category of challenge.
Characterization of a vitamin D3-resistant MCF-7 cell line. (1996)

1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the active metabolite of vitamin D3, is a potent inhibitor of breast cancer cell growth both in vivo and in vitro. We have previously demonstrated that 1,25-(OH)2D3 induces morphology (pyknotic nuclei, chromatin and cytoplasmic condensation, and nuclear matrix protein reorganization) consistent with the activation of apoptosis in MCF-7 cells. These morphological changes in 1,25-(OH)2D3-treated cells are associated with up-regulation of TRPM-2/clusterin and cathepsin B (genes associated with mammary gland apoptosis) and down-regulation of bcl-2, an antiapoptotic gene. Thus, the inhibitory effects of 1,25-(OH)2D3 on MCF-7 cell growth involve activation of apoptosis. To investigate the mechanisms by which vitamin D3 activates apoptosis, we have selected a vitamin D3-resistant variant (MCF-7D3Res cells) by continuous culture of MCF-7 cells in 100 nM 1,25-(OH)2D3. The MCF-7D3Res cells represent a stably selected phenotype that grows equally well with or without 100 nM 1,25-(OH)2D3. In contrast to the MCF-7 cells from which they were derived (MCF-7WT cells), MCF-7D3Res cells do not exhibit apoptotic morphology, DNA fragmentation, or up-regulation of apoptosis-related proteins after treatment with 1,25-(OH)2D3. MCF-7D3Res cells exhibit cross-resistance to several vitamin D3 analogs that are potent growth regulators of MCF-7WT cells. MCF-7WT and MCF-7D3Res cells exhibit comparable sensitivity to induction of apoptosis and up-regulation of clusterin in response to the antiestrogen 4-hydroxytamoxifen. MCF-7D3Res cells express comparable levels of the vitamin D receptor (VDR), as assessed by Western blotting or ligand binding, as MCF-7WT cells. In both sensitive and resistant cell lines, 1,25-(OH)2D3 up-regulates whereas 4-hydroxytamoxifen down-regulates VDR protein expression, indicating appropriate homologous and heterologous VDR regulation in MCF-7D3Ras cells. Gel shift analyses indicate that nuclear extracts from MCF-7WT and MCF-7D3Res cells bind equally well to the DR3 consensus vitamin D3 response element. These data suggest that MCF-7D3Res cells have a functional VDR that is uncoupled from a functional apoptotic pathway. MCF-7D3Res cells offer a unique model system for identification of the mechanisms by which vitamin D3 regulates the cell death pathway in breast cancer cells.
Design and Analysis of Separate-Absorption-Transport-Charge-Multiplication Traveling-Wave Avalanche Photodetectors (2004)

This paper proposes a novel type of avalanche photodiode-the separate-absorption-transport-charge-multiplication (SATCM) avalanche photodiode (APD). The novel design of photoabsorption and multiplication layers of APDs can avoid the photoabsorption layer breakdown and hole-transport problems, exhibit low operation voltage, and achieve ultra-high-gain bandwidth product performances. To achieve low excess noise and ultra-high-speed performance in the fiber communication regime (1.3/spl sim/1.55 /spl mu/m), the simulated APD is Si-based with an SiGe-Si superlattice (SL) as the photoabsorption layer and traveling-wave geometric structures. The frequency response is simulated by means of a photo-distributed current model, which includes all the bandwidth-limiting factors, such as the dispersion of microwave propagation loss, velocity mismatch, boundary reflection, and multiplication/transport of photogenerated carriers. By properly choosing the thicknesses of the transport and multiplication layers, microwave propagation effects in the traveling-wave structure can be minimized without increasing the operation voltage significantly. A near 30-Gb/s electrical bandwidth and 10/spl times/ avalanche gain can be achieved simultaneously, even with a long device absorption length (150 /spl mu/m) and low operation voltage (/spl sim/12 V). In addition, the ultrahigh output saturation power bandwidth product of this simulated TWAPD structure can also be expected due to the large photoabsorption volume and superior microwave-guiding structure.
Production of Low-Pressure Planar Non-Magnetized Plasmas Sustained under a Dielectric-Free Metal-Plasma Interface (1998)

Large-area Ar and CF 4 non-magnetized plasmas were produced in an entirely metal (stainless steel) plasma chamber with a diameter of 220 mm by 2.45 GHz electromagnetic wave launched by slot antennas cut in the top circular metal lid. Dielectric (quartz) was used only for local vacuum sealing over the slot antennas, occupying less than 20% of the top metal area. At low pressure of 10 mTorr, overdense (>10 11 cm -3 ) plasma was produced filling the whole chamber cross-section similarly to the known case of surface-wave plasmas produced below a large dielectric window covering 100% of the top chamber lid. The absence of this large dielectric suggests that this approach can be used for developing large-area non-magnetized plasma source with less impurities for thin-film processing.
Design Of A Wavelength Division Multiplexing/Demultiplexing System For Optical Intersatellite Links (1987)

Optical communications is an alternative to the microwave solution for high data rate interorbit (IOL) or intersatellite link (ISL), typically 500 Mbit/s. The optical system, using laser diode technology, only requires small size antennae, provided that multiplexing or power combining techniques are used. This paper presents a Wavelength Division Multiplexing/Demultiplexing System involving orthogonal polarizations for adjacent channels. This solution is preferred to the power combining technique to satisfy some specific system and interfaces constraints and to avoid a very accurate control of laser wavelength. The proposed design complies with system constraints like redundancy, minimum back-light on the laser junction, interchannel interferences, depolarization in the optical system, compacity, ... Its simplicity -the required components are only λ/4 plates, filters under normal incidence and polarizer beamsplitters- is attractive and the concept, descri-bed here for 4 wavelengths in the 0.817-0.84311μ range, can be applied to an unlimited number of wavelengths. The computed performances in transmission and isolation taking into account all parasitic reflections are given. A breadboard model is currently under development at MATRA to be tested in 1987. Preliminary results of sub-assemblies tests are presented.
Lactation performance of sows fed a bulky diet during gestation and receiving growth hormone-releasing factor during lactation. (1996)

Forty-eight crossbred gilts were used in an experiment with a 2 x 2 x 2 factorial arrangement of treatments. Treatments were control or bulky diet during gestation (4.1 vs 15.3% crude fiber), number of meals served daily in lactation (2 vs 4), and three daily s.c. injections of saline or of 1 mg of a human growth hormone-releasing factor analog (GRF-AN) from d 3 to 29 of lactation. Weights of pigs were recorded weekly until weaning on d 33. On d 29 of lactation, milk yield was estimated and a milk sample was obtained the next day. Jugular blood samples were collected from the sows on d 3 and 28 of lactation. Feed and water intake of sows were recorded throughout the study. Feeding the bulky diet decreased water intake in gestation (P < .001) and increased feed intake in lactation (P < .03). The number of meals served daily had no effect on feed intake during lactation (P > .1). Injections of GRF-AN increased IGF-I concentrations in blood (P < .01) and in milk (P < .001) and decreased backfat thickness (P < .001) and feed intake (P < .001) of sows during lactation. Pigs from sows injected with GRF-AN weighed more on d 14 (P < .05) and had a tendency to weigh more on d 7 (P = .09) and d 21 (P = .06). The incidence of sows showing estrus within 10 d of weaning was reduced with exogenous GRF (P < .01). The use of exogenous GRF in lactating sows may therefore have beneficial effects on growth of the pigs, yet the optimal nutritional and hormonal conditions needed for GRF to exert its full potential still need to be determined.
Stimulation of Clonal Growth of Human Colorectal Tumor Cells by IL-3 and GM-CSF (1990)

We studied the influence of recombinant human (rh) interleukin-3 (IL-3) and rh granulocyte-macrophage colony-stimulating factor (GM-CSF) on the clonal growth of a human colorectal adenocarcinoma cell line in a methylcellulose assay for colony growth of solid tumor cell lines (HTCAMC) and a capillary modification of a human tumor cloning assay in agar (HTCAcap). Both growth factors stimulated the clonal growth of this cell line in a dose-dependent fashion. Neutralizing the monoclonal antibody abolished the effect of rhGM-CSF. There was an inverse correlation between the spontaneous plating efficacy (PE) of the cells and their susceptibility to the stimulation by the growth factors. From day 4 to 7 we found conditions in which clusters and colonies occurred preferentially in the growth factor-stimulated cultures. Single colonies taken from these cultures grew rapidly into macroscopically visible tumors in liquid cultures and had a high secondary PE (PE2) in the HTCAcap, both presenting an argument against a differentiating effect of the growth factors on this tumor cell line. Furthermore, we were able to define conditions in which rhGM-CSF significantly increased the cytotoxicity of 5-fluorouracil (5-FU). However, this effect was dependent on spontaneous PE of the cells, degree of stimulation by the factor, degree of cytotoxicity of 5-FU in the controls, as well as the therapeutic regimen. Since there were only narrow margins for a beneficial effect of rhGM-CSF in this setting when absolute numbers of surviving colonies were counted, it remains doubtful whether this approach will be exploitable in the clinical situation.
The Applicability of the Perturbation Model-based Privacy Preserving Data Mining for Real-world Data (2006)

Perturbation method is a very important technique in privacy preserving data mining. In this technique, loss of information versus preservation of privacy is always a trade off. The question is, how much are the users willing to compromise their privacy? This is a choice that changes from individual to individual. In this paper, we propose an individually adaptable perturbation model, which enables the individuals to choose their own privacy level. Hence our model provides different privacy guarantees for different privacy preferences. We test our new perturbation model by applying different reconstruction methods to the perturbed data sets. Furthermore, we build decision tree and Naive Bayes classifier models on the reconstructed data sets both for synthetic and real world data sets. For the synthetic data set, our experimental results indicate that our model enables the users to choose their own privacy level without reducing the accuracy of the data mining results. For the real world data sets, we got very interesting results, hence we pose the question of whether the perturbation reconstruction model-based privacy preserving data mining is applicable for real-world data?
Geschichte und Restaurierung der Kaffeekanne des gelben Resopal-Geschirrs von Christian Dell (2013)

Die Bedeutung des Kaffeegeschirrs von Christian Dell und die restauratorische Untersuchung der dazugehorigen Kaffeekanne wird beschrieben. Die Untersuchungen lassen vermuten, dass es sich um einen Prototyp handelt.
New objective measurement to characterize the porosity of textile implants (2007)

The inflammatory and fibrotic intensity of a foreign body reaction largely depends on the porosity of the implanted material. Furthermore, the size of the pore and its geometry define the capability to allow tissue ingrowth. We present an image analysis system, which allows objectifying in two dimensions the pores' structure and geometry of textile fabrics, that are used to reinforce the abdominal wall or pelvic floor. The porosity of the textile is measured at four samples with differences in structure. The porosity decreases markedly if foreign body response is considered, leading to the definition of an "effective porosity". Because of the high stiffness of the polymer fibers the elasticity of textile implants usually result from a deformation of the pores, leading to a marked reduction of the effective porosity if a mechanical stress is applied. Further in vivo studies have to investigate, whether the preservation of a high effective porosity under stress may help to improve biocompatibility of textile implants.
On an iterative algorithm for calculating weighted principal components (2015)

An iterative algorithm for calculating weighted principal components, which enables substantial reduction of the average (over the sample) weighted maximum (along a coordinate) reconstruction error of sample vectors from compressed data, is designed. The results of simulation, which illustrate the efficiency of this algorithm, are given.
Absolute photonic band gap in a two-dimensional square lattice of square dielectric rods in air (1997)

We show that an absolute photonic band gap exists in a two-dimensional square lattice of square dielectric rods in air. The index of refraction of the square dielectric rods must be larger than 2.65 to have the band gap. This structure is a good candidate for two-dimensional photonic crystals in the IR or the visible to near-IR wavelength range, and can be applied to high efficiency optoelectronic devices.
Inhibition of tumor invasion and metastasis by a novel lysophosphatidic acid (cyclic LPA) (1999)

Fetal calf serum (FCS) and 1-oleoyl lysophosphatidic acid (LPA) were previously found to be potent inducers of invasion (transcellular migration) in an in vitro system. A novel LPA, composed of cyclic phosphate and cyclopropane-containing hexadecanoic acid (PHYLPA), first isolated from myxoamoebae of Physarum polycephalum, and its synthetic derivatives (cLPA) were tested for their ability to inhibit tumor cell invasion and metastasis. Amoung these, Pal-cLPA, which has a palmitoyl moiety, was most potent in inhibiting invasion, with 93.8% inhibition at the concentration of 25 microM. Invasion in vitro by mouse melanoma cells (B16), human pancreatic adenocarcinoma cells (PSN-1), human lung cancer cells (OC-10) and human fibrosarcoma cells (HT-1080) was also inhibited by Pal-cLPA. The stimulation of MMI cells with LPA triggered F-actin formation, which was impaired by the addition of Pal-cLPA at invasion-inhibitory concentration. Pal-cLPA induced a rapid increase in adenosine 3',5'-cyclic monophosphate (cAMP) concentration in MMI cells. The addition of dibutyryl cAMP significantly abrogated LPA-induced invasion by MM1 cells and actin polymerization in the cells. The inhibition of MM1 cell invasion by Pal-cLPA may be ascribed to an increased level of cAMP. Pal-cLPA also suppressed invasion in vitro by MM1 cells induced by FCS dose dependently, without affecting proliferation. It also suppressed the pulmonary metastasis of B16 mouse melanoma cells injected into the tail vein of C57BL/6 mice. Thus, Pal-cLPA is effective in inhibiting invasion and metastasis of a variety of tumor cells.
Synthetic Approaches for Nucleic Acid Delivery: Choosing the Right Carriers (2019)

The discovery of the genetic roots of various human diseases has motivated the exploration of different exogenous nucleic acids as therapeutic agents to treat these genetic disorders (inherited or acquired). However, the physicochemical properties of nucleic acids render them liable to degradation and also restrict their cellular entrance and gene translation/inhibition at the correct cellular location. Therefore, gene condensation/protection and guided intracellular trafficking are necessary for exogenous nucleic acids to function inside cells. Diversified cationic formulation materials, including natural and synthetic lipids, polymers, and proteins/peptides, have been developed to facilitate the intracellular transportation of exogenous nucleic acids. The chemical properties of different formulation materials determine their special features for nucleic acid delivery, so understanding the property-function correlation of the formulation materials will inspire the development of next-generation gene delivery carriers. Therefore, in this review, we focus on the chemical properties of different types of formulation materials and discuss how these formulation materials function as protectors and cellular pathfinders for nucleic acids, bringing them to their destination by overcoming different cellular barriers.
Experiments on atomic-scale mechanisms of diffusion (1991)

Many substitutional impurities in crystalline solids diffuse by a hybrid mechanism involving a fast-migrating intermediate species. Nonequilibrium measurements of the migration frequency g and migration length \ensuremath{\lambda} for such an impurity can provide definitive data on atomic-scale diffusion mechanisms. We report the first experimental study to exploit this approach. The system investigated is B in crystalline Si. B is shown to diffuse predominantly via a migrating interstitial species ${\mathrm{B}}_{\mathit{i}}$, generated by a kick-out reaction. The observed mechanism and energetics agree with recent total-energy calculations.
APPLICATION OF IMAGE SONIFICATION METHODS TO MUSIC (2005)

To utilize visual information for musical purpose, inevitable time-based nature of sound should be understood and considered.Time is the principle dimension within which all other auditory parameters are placed, and this poses a particular challenge to effective sonification of time independent images and their applications to music.In this paper we present two concepts of time mapping, scanning and probing, to provide a framework for conceptualizing mappings of static data to the time domain.We then consider the geometric characteristics of images to define meaningful references in time.Finally we discuss combination of scanning and probing methods in relation to human image perception model, and proceed to suggest its musical applications and implementation with SonART.
Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines (1983)

A series of 6-[(arylamino)methyl]-2,4-quinazolinediamines have been prepared by catalytic hydrogenation of the requisite 2,4-diamino-6-quinazolinecarbonitriles in the presence of the appropriate benzenamine. Formylation, acetylation, and nitrosation provided N omega derivatives of these compounds. A variety of the compounds exhibited potent antimalarial, antibacterial, and antitumor activity. In particular, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)-amino]methyl]-2, 4-quinazolinediamine (trimetrexate, 15) has shown a broad spectrum of antitumor effects and is undergoing preclinical toxicology evaluation prior to trial in man.
Automation of flow injection gas diffusion‐ion chromatography for thenanomolar determination of methylamines and ammonia in seawater and atmosphericsamples (1995)

The automation and improved design and performance of Flow Injection Gas Diffusion-Ion Chromatography (FIGD-IC), a novel technique for the simultaneous analysis of trace ammonia (NH(3)) and methylamines (MAs) in aqueous media, is presented. Automated Flow Injection Gas Diffusion (FIGD) promotes the selective transmembrane diffusion of MAs and NH(3) from aqueous sample under strongly alkaline (pH > 12, NaOH), chelated (EDTA) conditions into a recycled acidic acceptor stream. The acceptor is then injected onto an ion chromatograph where NH(3) and the MAs are fully resolved as their cations and detected conductimetrically. A versatile PC interfaced control unit and data capture unit (DCU) are employed in series to direct the selonoid valve switching sequence, IC operation and collection of data. Automation, together with other modifications improved both linearily (R(2) > 0.99 MAs 0-100 nM, NH(3) 0-1000 nM) and precision (<8%) of FIGD-IC at nanomolar concentrations, compared with the manual procedure. The system was successfully applied to the determination of MAs and NH(3) in seawater and in trapped particulate and gaseous atmospheric samples during an oceanographic research cruise.