gebhart/patrepeval huggingface dataset:
Comparison between MAGIC LITE®‐ and CAP®‐system: two automated specific IgE antibody assays (1992)

The MAGIC LITE system, a newly developed immunochemiluminometric assay for specific and total IgE antibody using paramagnetic particles coupled with standardized allergens as solid phase, was compared to the CAP system, a recently introduced immunoassay based on a cellulose polymer encased in a capsule. A total of 357 serum samples of patients with suspected inhalant allergies and a positive skin prick test (SPT) to common allergens (birch, timothy-grass, mugwort, cat dander, Dermatophagoides pteronyssinus, Alternaria) were investigated. Fifty SPT negative subjects served as controls (total number of tests in each assay = 1600). Both assays were highly precise (overall intra-assay and inter-assay coefficients of variation were 2.9% and 4.5% in MAGIC LITE, 4.7% and 5.5% in CAP) and showed excellent linearity (mean r2 of eightfold log2 serum dilutions were 99.7% and 99.3% in MAGIC LITE and CAP). Good correlations were found between the absolute specific IgE antibody values detected by both methods (correlation coefficient r: birth 0.86, grass 0.93, mugwort 0.96, cat 0.91, D. pteronyssinus 0.73, Alternaria 0.90). Excellent specificity (greater than or equal to 98%) occurred in both assays and with all allergens, and sensitivity was related to the allergen (MAGIC LITE/CAP): birch 91%/89%, grass 83%/90%, mugwort 50%/69%, cat 83%/83%, D. pteronyssinus 72%/78%, Alternaria 75%/81%. Our results indicate that both in vitro tests are useful tools for the detection of specific IgE antibody.
Versatile microcomputer-controlled titrator (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVersatile microcomputer-controlled titratorA. H. B. Wu and H. V. MalmstadtCite this: Anal. Chem. 1978, 50, 14, 2090–2096Publication Date (Print):December 1, 1978Publication History Published online1 May 2002Published inissue 1 December 1978https://pubs.acs.org/doi/10.1021/ac50036a037https://doi.org/10.1021/ac50036a037research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A segmental HMM for speech pattern modelling (1993)

A simple segmental hidden Markov model (HMM) which addresses some of the limitations of conventional HMM-based methods is proposed. The important features of this approach are the use of an underlying semi-Markov process, in which state transitions are segment-synchronous rather than frame-synchronous and state duration is modeled explicitly, and a state segment model in which separate statistical processes are used to characterize extra-segmental and intra-segmental variability. A basic mathematical analysis of Gaussian segmental HMMs is presented, and model parameter reestimation equations are derived. The relationship between the new type of model and variable frame rate analysis and conventional Gaussian mixture based HMMs is explained.< <ETX>></ETX>
Synthesis and Biological Evaluation of Substituted <i>N</i>‐[3‐(1<i>H</i>‐Pyrrol‐1‐yl)methyl]‐1,2,5,6‐tetrahydropyridin‐1‐yl]benzamide/benzene Sulfonamides as Anti‐Inflammatory Agents (2014)

The pharmacological activities of tetrahydropyridine (THP) derivatives are dependent on the substituent ring moiety. In this study, we investigate the anti-inflammatory activities of 12 newly synthesized substituted N-[3-(1H-pyrrol-1-yl)methyl]-1,2,5,6-tetrahydrobenzamide/benzene sulfonamides (9a-l) in murine BV-2 microglial cells. All compounds were initially screened for attenuation of nitric oxide (NO) production in lipopolysaccharide (LPS) (1 µg/mL)-activated microglial cells. The data show that only SO2 -substituted THPs were effective at sub-lethal concentrations (IC50 values of 12.92 µM (9i), 14.64 µM (9j), 19.63 µM (9k)) relative to L-N6-(1-iminoethyl)lysine positive control (IC50 = 3.1 µM). The most potent SO2 -substituted compound (9i) also blocked the LPS-inducible nitric oxide synthase (iNOS) and attenuated the release of several cytokines including IL-1α, IL-10, and IL-6. These findings establish the moderate immuno-modulating effects of SO2 -substituted THP derivatives.
Cascaded Incremental Nonlinear Dynamic Inversion Control for MAV Disturbance Rejection (2017)

Micro Aerial Vehicles (MAVs) are limited in their operation outdoors near obstacles by their ability to withstand wind gusts. Currently widespread position control methods such as Proportional Integral Derivative control do not perform well under the influence of gusts. Incremental Nonlinear Dynamic Inversion (INDI) is a sensor-based control technique that can control nonlinear systems subject to disturbances. It was developed for the attitude control of manned aircraft or MAVs. In this paper we generalize this method to the outer loop control of MAVs under severe gust loads. Significant improvements over a traditional Proportional Integral Derivative (PID) controller are demonstrated in an experiment where the quadrotor flies in and out of a windtunnel exhaust at 10 m/s. The control method does not rely on frequent position updates, as is demonstrated in an outside experiment using a standard GPS module. Finally, we investigate the effect of using a linearization to calculate thrust vector increments, compared to a nonlinear calculation. The method requires little modeling and is computationally efficient.
"Movemental": Integrating Movement and the Mental Game (2011)

A videogame or simulation may be physiologically modulated to enhance engagement by challenging the user to achieve a target physiological state. A method and several implementations for accomplishing this are described.
Microprocessors in consumer products (1978)

The impact of LSI and microprocessor technology on a host of home consumer products is overviewed. Trends in LSI technology are reviewed in particular as they affect programmable video display architectures. The programmable video game market is discussed and current product offerings are briefly described. The design tradeoffs associated with the RCA Studio H product are detailed, and a brief look into the future is presented.
One-stage anterior and posterior hemivertebral resection and arthrodesis for congenital scoliosis. (1990)

Seven children who had congenital scoliosis due to a single, fully segmented lumbar hemivertebra were treated with single-stage anterior and posterior vertebral resection and arthrodesis. The scoliosis averaged 47 degrees preoperatively, 14 degrees postoperatively, and 15 degrees (approximately 70 per cent correction) after an average follow-up of 45.6 months. Four patients had thoracolumbar kyphosis preoperatively, and it remained unchanged at the most recent follow-up examination. Postoperatively, a cast was worn for twelve to sixteen weeks, after which a brace was applied. There were no neurological deficits, infections, deaths, or pseudarthroses. The combined procedure was well tolerated and, in the limited period of follow-up, the congenital scoliosis did not progress.
Reversible adsorption of oxygen on silica gel modified by imidazole-attached iron tetraphenylporphyrin (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReversible adsorption of oxygen on silica gel modified by imidazole-attached iron tetraphenylporphyrinOrlando Leal, David L. Anderson, Robert G. Bowman, Fred Basolo, and Robert L. Burwell Jr.Cite this: J. Am. Chem. Soc. 1975, 97, 18, 5125–5129Publication Date (Print):September 1, 1975Publication History Published online1 May 2002Published inissue 1 September 1975https://doi.org/10.1021/ja00851a017RIGHTS & PERMISSIONSArticle Views642Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (583 KB) Get e-Alertsclose Get e-Alerts
Fetal Cardiac Function: M-Mode and 4D Spatiotemporal Image Correlation (2012)

Fetal cardiac function has been shown to be a marker of disease severity in many conditions, including intrauterine growth restriction, congenital heart defects or disease (CHD), twin-to-twin transfusion syndrome, idiopathic hydrops, fetal arrhythmias, and others. It is often targeted for evaluation of patient management, for providing complete and accurate diagnoses in CHD, for patient counseling, or in referring for fetal cardiac interventions. In this review we will describe the use of M-mode and 4D spatiotemporal image correlation in fetal cardiac evaluation, the parameters that can be measured, and their application to clinical practice.
Load-balancing heuristics and process behavior (1986)

Dynamic load balancing in a system of loosely-coupled homogeneous processors may employ both judicious initial placement of processes and migration of existing processes to processors with fewer resident processes. In order to predict the possible benefits of these dynamic assignment techniques, we analyzed the behavior (CPU, disk, and memory use) of 9.5 million Unix* processes during normal use. The observed process behavior was then used to drive simulation studies of particular dynamic assignment heuristics. Let F (·) be the probability distribution of the amount of CPU time used by an arbitrary process. In the environment studied we found: (1- F ( x )) ≉ rx - c , 1.05< c <1.25. F (·) is far enough from exponential to make exponential models of little use. With a foreground-background process scheduling policy in each processor, simple heuristics for initial placement and processor migration can significantly improve the response ratios of processes that demand exceptional amounts of CPU, without harming the response ratios of ordinary processes.
Decomposition Of Benzene By A Low Pressure Glow Discharge (2003)

Decomposition characteristics of diluted benzene with nitrogen in a low pressure DC glow discharge plasma are investigated by emission spectroscopy, mass spectrometry, infrared absorption spectroscopy, concentration measurement and gas pressure monitoring. It is likely that benzene is decomposed chiefly by electron collision, and that excite molecules of nitrogen and/or nitrogen ions do not make a large contribution to benzene destruction directly. It is found that H, H2, H3, C, CH, CH4, NH3, C2, C2H, CN, C2H2, and C2H4 are produced in the glow discharge.
Interaction of Antioxidants and Their Implication in Genetic Anemia (1999)

The generation of reactive oxygen species (ROS) is a steady-state cellular event in respiring cells. Their production can be grossly amplified in response to a variety of pathophysiological conditions such as inflammation, immunologic disorders, hypoxia, hyperoxia, metabolism of drug or alcohol, exposure to UV or therapeutic radiation, and deficiency in antioxidant vitamins. Uncontrolled production of ROS often leads to damage of cellular macromolecules (DNA, protein, and lipids) and other small antioxidant molecules. A number of major cellular defense mechanisms exist to neutralize and combat the damaging effects of these reactive substances. The enzymic system functions by direct or sequential removal of ROS (superoxide dismutase, catalase, and glutathione peroxidase), thereby terminating their activities. Metal binding proteins, targeted to bind iron and copper ions, ensure that these Fenton metals are cryptic. Nonenzymic defense consists of scavenging molecules that are endogenously produced (GSH, ubiquinols, uric acid) or those derived from the diet (vitamins C and E, lipoic acid, selenium, riboflavin, zinc, and the carotenoids). These antioxidant nutrients occupy distinct cellular compartments and among them, there are active recycling. For example, oxidized vitamin E (tocopheroxy radical) has been shown to be regenerated by ascorbate, GSH, lipoic acid, or ubiquinols. GSH disulfides (GSSG) can be regenerated by GSSG reductase (a riboflavin-dependent protein), and enzymic pathways have been identified for the recycling of ascorbate radical and dehydroascorbate. The electrons that are used to fuel these recycling reactions (NADH and NADPH) are ultimately derived from the oxidation of foods. Sickle cell anemia, thalassemia, and glucose-6-phosphate-dehydrogenase deficiency are all hereditary disorders with higher potential for oxidative damage due to chronic redox imbalance in red cells that often results in clinical manifestation of mild to serve hemolysis in patients with these disorders. The release of hemoglobin during hemolysis and the subsequent therapeutic transfusion in some cases lead to systemic iron overloading that further potentiates the generation of ROS. Antioxidant status in anemia will be examined, and the potential application of antioxidant treatment as an adjunct therapy under these conditions will be discussed.
Distinct types of hubs in human dynamic networks (2008)

The emergence of Delay Tolerant Networks (DTNs) has culminated in a new generation of wireless networking. New communication paradigms using dynamic interconnectedness as people encounter each other lead towards a world where digital traffic flows. We focus on human-to-human communication in such environments, which exhibits the characteristics of social networks. Among various social contexts, we examine hubs in dynamic human networks. Hubs are highly connected nodes within the network. This paper describe hubs in time-dependent netwowrks and two distinct types of hubs: party and date hubs from real world connectivity traces.
The epidermal growth factor/transforming growth factor-?? family and their receptors (1995)

Cytokines and growth factors act as intercellular signalling molecules which control cellular functions during development and in response to injury or infection. The epidermal growth factor (EGF) family is an expanding group of structurally related polypeptides that regulate cell proliferation, migration and differentiation, via tyrosine kinase receptors on target cells. This chapter reviews recent developments in the characterization of EGF family members and their receptors.
A Novel Data-Aided Channel Estimation With Reduced Complexity for TDS-OFDM Systems (2012)

In contrast to the classical cyclic prefix (CP)-OFDM, the time domain synchronous (TDS)-OFDM employs a known pseudo noise (PN) sequence as guard interval (GI). Conventional channel estimation methods for TDS-OFDM are based on the exploitation of the PN sequence and consequently suffer from intersymbol interference (ISI). This paper proposes a novel data-aided channel estimation method which combines the channel estimates obtained from the PN sequence and, most importantly, additional channel estimates extracted from OFDM data symbols. Data-aided channel estimation is carried out using the rebuilt OFDM data symbols as virtual training sequences. In contrast to the classical turbo channel estimation, interleaving and decoding functions are not included in the feedback loop when rebuilding OFDM data symbols thereby reducing the complexity. Several improved techniques are proposed to refine the data-aided channel estimates, namely one-dimensional (1-D)/two-dimensional (2-D) moving average and Wiener filtering. Finally, the MMSE criteria are used to obtain the best combination results and an iterative process is proposed to progressively refine the estimation. Both MSE and BER simulations using specifications of the DTMB system are carried out to prove the effectiveness of the proposed algorithm even in very harsh channel conditions such as in the single frequency network (SFN) case.
A Multicenter Study of Patient-Reported Infectious and Noninfectious Complications Associated With Indwelling Urethral Catheters (2018)

Noninfectious complications of urethral catheters affect a substantial number of patients, underscoring the importance of avoiding urethral catheterization whenever possible. Given the high incidence of these patient-reported complications, urethral catheter-associated noninfectious complications should be a focus of surveillance and prevention efforts.
Oral administration of human serum immunoglobulin in immunodeficient patients with viral gastroenteritis. A pharmacokinetic and functional analysis. (1985)

We examined the pharmacokinetics and immunological activity of human serum immunoglobulins (HSG) possessing anti-rota-virus activity which were orally administered to three children with primary immunodeficiency syndromes and prolonged gastrointestinal excretion of rotavirus. Detailed analysis of the excretion of immunoglobulins labeled with biotin or I125 revealed that approximately 50% of the recovered radioactivity was excreted in the stools over a 3-d period. Approximately half of the excreted radioactivity recovered in the stool was in a macromolecular form with immunological activity. The remainder of the recovered radioactivity was excreted in the urine as low molecular weight fragments or free iodide. In addition, immunological and chromatographic analyses revealed that the oral administration of HSG resulted in the generation of rotavirus-specific immune complexes in the gastrointestinal tract with a subsequent decrease in the presence of uncomplexed rotavirus antigen. These studies indicate that orally administered HSG can survive passage in the gastrointestinal tract in an immunologically active form, and that the oral administration of immunoglobulins with specific reactivities has potential for the prevention or treatment of gastrointestinal infections.
A high voltage ion-implanted MOSFET (1971)

The drain breakdown voltage of usual p-channel MOS devices is limited to about 30 to 40 V by field crowding at the drain junction. By optimizing certain design parameters like diffusion depth, substrate resistivity and gate oxide thickness, 80 V breakdowns can be achieved. To date, higher breakdowns are only possible with special device geometries (e.g. the stacked gate tetrode) which are generally not compatible with common MOS processes. By adding an ion-implantation step to the conventional aluminum-gate MOS process, it is possible to fabricate MOSSFET's with source-drain breakdown potentials of greater than 240 V on the same chip with conventional MOS circuitry. The device looks identical to the conventional MOSFET except that an unmetalized gate oxide region is left between the gate and the drain juction. During a subsequent ion-implantation this portion of the channel is lightly doped with a p-type dopant in the case of p-channel devices. Since-both the metal and the field oxide are thick enough to stop all ions, the implantation affects only the high voltage devices on the wafer. The implanted channel has the effect of reducing the field in the vicinity of the drain junction, thereby increasing the source-drain breakdown voltage. P-channel devices were made on 10 Ω-cm material using 1µm diffused junctions. The aluminum gate was 10 µm long and the implanted channel was 25µm long. Breakdowns up to 240 V were achieved after an optimum dose of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2 \times 10^{12}</tex> boron ions/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> were implanted at 80 keV through 1300 Å of gate SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> . The wafers were subsequently annealed for 15 minutes at 525°C in N <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> . Implanted resistors made at the same time had sheet resistivities of 25 kΩ/□. Of critical importance in obtaining best results are low threshold voltages and accurate implantation dose control To obtain long term reliability it is necessary to prevent charge build-up on the oxide over the implanted channel. This is accomplished by the deposition of a layer of phosphosilicate glass after ion-implantation. It is now possible to include decoding circuitry on the same chip as the high voltage drivers for display tubes.
Involvement of IL-10 in the autonomous growth of EBV-transformed B cell lines (1997)

Immunocompromised individuals have an increased incidence of EBV-associated B cell lymphomas. The growth factors responsible for the unrestrained proliferation of these lymphomas have not yet been determined. In this study, spontaneous lymphoblastoid cell lines (SLCL) were derived without the addition of growth factors or virus from four patients with EBV-associated lymphoproliferative disorder. These cell lines were EBV transformed in vivo, and infection was verified through amplification of the viral gp220 gene. SLCL have an activated B cell phenotype (CD19+, CD21+, CD23+, CD38+, and CD40+) and produce IL-6, IL-10, TNF-alpha, and lymphotoxin-alpha. To determine whether these cytokines contribute to autonomous growth, neutralizing Abs for IL-10, IL-6, and TNF-alpha, a soluble TNFR:Fc fusion protein, and soluble IL-10R were used. These experiments established that, of the cytokines produced by SLCL, only IL-10 is an autocrine factor. IL-10 was produced by the majority of cells within each SLCL, and IL-10 secretion was concomitant with SLCL growth. Our findings demonstrate that IL-10 is utilized in the autonomous growth of EBV-related lymphomas and may be crucial in the development of lymphoproliferative disorder.
Left Ventricular Aneurysmectomy in Advanced Left Ventricular Dysfunction (1995)

Despite widespread application in clinical practice and extensive laboratory investigations, many basic issues regarding left ventricular aneurysmectomy remain to be resolved. Analysis of clinical data from the authors' three centers and application of powerful modern imaging techniques provide important information to resolve these issues.