gebhart/patrepeval huggingface dataset:
Characterization of the Fast Dynamics of Protein Amino Acid Side Chains Using NMR Relaxation in Solution (2006)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of the Fast Dynamics of Protein Amino Acid Side Chains Using NMR Relaxation in SolutionTatyana I. Igumenova, Kendra King Frederick, and A. Joshua WandView Author Information Johnson Research Foundation and Department of Biochemistry & Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6059 Cite this: Chem. Rev. 2006, 106, 5, 1672–1699Publication Date (Web):April 26, 2006Publication History Received20 March 2006Published online26 April 2006Published inissue 1 May 2006https://pubs.acs.org/doi/10.1021/cr040422hhttps://doi.org/10.1021/cr040422hresearch-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views3160Altmetric-Citations279LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alkyls,Magnetic properties,Order,Peptides and proteins,Protein dynamics Get e-Alerts
Effects of Oral and Gastric Stimulation on Appetite and Energy Intake (2012)

Appetite is regulated by many factors, including oro-sensory and gastric signals. There are many studies on contributions of and possible interaction between sensory and gastric stimulation, but there are few studies in humans using simultaneous oral and gastric stimulation. We investigated the effect of simultaneous, but independently manipulated, oral and gastric stimulation on appetite ratings and energy intake. We hypothesized that compared with no stimulation, oral and gastric stimulation would equally and additively decrease appetite ratings and energy intake. Healthy men (n = 26, 21 ± 2 years, BMI 22 ± 3 kg/m(2)) participated in a randomized crossover trial with four experimental conditions and a control condition. Experimental conditions consisted of oral stimulation, with either 1 or 8 min modified sham feeding (MSF), and gastric stimulation, with either 100 or 800 ml intragastrically infused liquid (isocaloric, 99 kcal, 100 ml/min). The control condition consisted of no oral or gastric stimulation. Outcome measures were energy intake 30 min after the treatment and appetite ratings. Compared with the control condition, energy intake decreased significantly after the 8 min/100 ml (19% lower, P = 0.001) and 8 min/800 ml conditions (15% lower, P = 0.02), but not after the 1 min/100 ml (14% lower, P = 0.06) and 1 min/800 ml conditions (10% lower, P = 0.39). There was no interaction of oral and gastric stimulation on energy intake. Hunger and fullness differed across all conditions (P ≤ 0.01). In conclusion, duration of oral exposure was at least as important in decreasing energy intake as gastric filling volume. Oral and gastric stimulation did not additively decrease energy intake. Longer oro-sensory stimulation, therefore, may be an important contributor to a lower energy intake.
Cu<sub>2</sub>O Decorated with Cocatalyst MoS<sub>2</sub> for Solar Hydrogen Production with Enhanced Efficiency under Visible Light (2014)

In this work, we have prepared a p-type semiconductor of Cu2O decorated with MoS2 nanosheets as cocatalyst for efficient solar hydrogen production under visible light. Results show that Cu2O decorated with 1.0 wt % MoS2 presents the maximum reduction photocurrent density of 0.17 mA cm–2, which is 7-fold higher than pristine Cu2O. Furthermore, the as-prepared MoS2@Cu2O exhibits remarkable photostability with only 7% loss of its original photocurrent after 9 h of continuous work. The excellent performance of MoS2@Cu2O is ascribed to the introduction of active sites of MoS2 nanosheets as cocatalyst to the surface of Cu2O nanoparticles, which activates the photocatalyst by lowering the electrochemical proton reduction overpotential and also inhibits photoinduced corrosion during the measurement.
Studying additive interaction in a healthcare database: Case study of NSAIDs, cardiovascular profiles, and acute myocardial infarction (2018)

Alternative specifications of NSAID exposure concurred in finding that concomitant use of cardioprotective aspirin does not attenuate the risks of acute MI with NSAIDs. However we were unable to demonstrate consistent interactions between an individual's cardiovascular comorbidities and NSAID-associated acute MI. Our study highlights challenges of studying additive interactions in a healthcare database and underscores the need for sensitivity analyses.
Temporal weighting in sound localization (2002)

The dynamics of sound localization were studied using a free-field direct localization task (pointing to sound sources) and an observer-weighting analysis that assessed the relative influence of each click in a click-train stimulus. In agreement with previous studies of the precedence effect and binaural adaptation, weighting functions showed increased influence of the onset click when the interclick interval (ICI) was short (<5 ms). For longer ICIs, all clicks in a train contributed roughly the same amount to listeners' localization responses. Finally, when a short gap was introduced in the middle of a train, the influence of the click immediately following the gap increased, in agreement with the "restarting" results obtained by Hafter and Buell [J. Acoust. Soc. Am. 88, 806-812 (1990)].
Reasons for not performing keratorefractive surgery in patients seeking refractive surgery in a hospital-based cohort in "Yemen" (2010)

Patients who requested keratorefractive surgery have a variety of problems and warrant comprehensive attention to selection criteria on the part of the surgeon. Corneal topographies and pachymetry of refractive surgery candidates need to be read cautiously. High-refractive error, keratoconus and insufficient corneal thickness were found to be the leading reasons for not performing keratorefractive surgery in this study.
Syntheses and Antimicrobial Activity of Acyl Derivatives of Heterocyclic Amines (1959)

Acyl derivatives of four kinds of heterocyclic amines of interest in pharmaceutical chemistry, thiazole, pyrimidine, thiazolone, and thiadiazoles, were prepared. The acyl compounds with 2-18 carbone atoms were prepared as 2-acylaminothiazole, 2-acylaminopyrimidine, 2-acylamino-4-thiazolone, and 2-acylamino-1, 3, 4-thiadiazole, and the compounds were screened for antimicrobial activity. Some compounds having growth inhibition against tubercle bacilli in 10-4 M concentration were found but none showed any activity against other bacteria or virus. In order to introduce an acyl group in N4 of N1-heterocyclic sulfanilamides, N4- acyl derivatives of sulfathiazole and sulfisoxazole were prepared and their antimicrobial activity was examined, but none showed any increased antibacterial activity over that of the parent sulfas. Only N4-decanoylsulfisoxazole was found to be significantly effective in vivo against Japanese B encephalitis virus.
Saponins from the leaves of Aralia elata Seem. (Araliaceae). (1990)

Eleven triterpenoidal saponins having oleanolic acid or hederagenin as the aglycone and two flavonoidal glycosides were isolated from the leaves of Aralia elata SEEM. (Araliaceae). The structures of four new saponins (1, 2, 3, and 4) were established to be 3-O-α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranosyl-hederagenin 28-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester, 3-O-α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranosyl-oleanolic acid 28-O-β-D-xylopyranosyl(1→6)-β-D-glucopyranosyl ester, 3-O-β-D-glucopyranosyl(1→3)-α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranosyl-hederagenin 28-O-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl ester, and 3-O-β-D-glucopyranosyl(1→3)-α-L-rhamnopyranosyl(1→2)-α-L arabinopyranosyl-hederagenin, respectively, on the basis of spectroscopic and chemical evidence.
Characterization of a PET Camera Optimized for Prostate Imaging (2006)

We present the characterization of a positron emission tomograph for prostate imaging that centers a patient between a pair of external curved detector banks (ellipse: 45 cm minor, 70 cm major axis). The distance between detector banks adjusts to allow patient access and to position the detectors as closely as possible for maximum sensitivity with patients of various sizes. Each bank is composed of two axial rows of 20 HR+ block detectors for a total of 80 detectors in the camera. The individual detectors are angled in the transaxial plane to point towards the prostate to reduce resolution degradation in that region. The detectors are read out by modified HRRT data acquisition electronics. Compared to a standard whole-body PET camera, our dedicated-prostate camera has the same sensitivity and resolution, less background (less randoms and lower scatter fraction) and a lower cost. We have completed construction of the camera. Characterization data and reconstructed images of several phantoms are shown. Sensitivity of a point source in the center is 946 cps/muCi. Spatial resolution is 4 mm FWHM in the central region
Taking Learning to Task: Creative Strategies for Teaching Adults (2002)

Taking Learning To Task: Creative Strategies for Teaching Adults Jane Vella San Francisco, California: Jossey-Bass Inc. Many educators are finding that they are a little outdated. With the idea of being out and the concept of facilitator in and objectives being out, but in, the feeling of panic can start to build. However, learning can be facilitated quite easily through learning tasks such as: group discussion, paired projects, case studies and very specific Many educators have discovered that students actually learn much more through interactive means versus straight lecture. Taking Learning to Task offers a new to present material to students. Anyone adults will find this a useful book. Vella's entire concept of teaching centers around the use of tasks. She identifies a learning task as a way to structure dialogue (p. xiii). Vella also states that Socrates, Jesus, and Buddha were great teachers who set great learning tasks because they knew the power of dialogue (p. xiu). The goal of learning tasks is to facilitate discussion between the teacher and the by using open-ended questions. Vella has identified four components that are needed to make an effective design for learning These are inductive work, input, implementation and integration. Inductive work is a learning task that incorporates what the already knows, or is related to their life. Input includes new content such as concepts, skills or attitudes. Implementation is the act of doing something with the new content (or input). And integration involves using the new content in a real life situation. When designing a course using these four components, an inductive task will use action verbs such as: describe, tell the story of, define, sketch, show, name, etc. This will help the to see how something they use daily in their lives or work affects their learning. An inductive task sets the stage for learning by sharpening the perception of the learner (p. 39). Input tasks will challenge the with new content. New content will be presented, a learning task given, and by this process learning will take place. An input task is different than an inductive task because new material is given. The material must be presented as a task for learners to work with, challenge, and recreate to fit their needs. These tasks will involve presenting substantive concepts, data, skill sets, and attitudes for examination, comparison, reflection, practice, editing, rearranging, and reconstructing (p. 40). Implementation tasks allow the to utilize the new concepts or skills they have learned. They should be given time to review, integrate, practice, and examine the new content. …
A Discussion of Calicum Carbonate Scaling Problems and Solutions With Respect to Produced Brines (1989)

ABSTRACT Seven barrels of oilfield brine are produced for every barrel-equivalent of energy obtained in the United States each year. With enhanced recovery of hydrocarbons this ratio can be as high as thirty or fifty to one. Scale deposited within production systems associated with high volumes of produced brine can pose serious problems to the operator. Controlling scale affects the economics of the field and a scale problem left untreated can result in the total loss of production or costly replacement of facilities. Predicting potential scaling problems can be difficult and numerous saturation indexes have been developed to assist in this regard. Some of these will be compared and contrasted along with the advantages and disadvantages of mainframe computer codes. Methods to inhibit scale formation can be varied and are vastly different with respect to economic impact and result. These possible methods including acidization, sequestration, dilution, pressure and temperature control, induced precipitation and inhibitor treatment by treat string and squeeze into the formation will be discused. Finally, the history of scale control in co-production gas wells will be presented. The discussion will focus on inhibitor treat string design and effectiveness and the planning and results of an inhibitor squeeze project.
Video assisted thoracic surgery. Experiences in Dr. Gustavo Aldereguia Lima hospital. (2008)

<strong>Background:</strong> Video assisted thoracic surgery is an intervention which advantages should be reaffirmed through studies aimed to characterize and describe it, based on real experiences. <strong><br />Objective:</strong> To verify the efficacy of this kind of surgery in the department of minimal access surgery in the university hospital Dr. Gustavo Aldereguia Lima. <strong><br />Methods:</strong> Descriptive, retrospective study of 135 patients operated through video assisted thoracic surgery in the university hospital in Cienfuegos during a period of seven years (1998-2005). The analyzed variables were: disease that determined the intervention, goals, of the intervention, complications and post-operatory period. <strong><br />Results:</strong> The most frequent causes of intervention were pneumothorax, pulmonary tumors, pleural effusion and empyema. There was high accordance between pre and pos operatory diagnosis. There was a prevalence of therapeutic surgeries (55 %), over diagnostic surgeries. The pos-operatory period in the Surgery Department was less than seven days in most of the cases. <strong><br />Conclusion:</strong> The study’s results show that the use of this technique has a positive impact on the economic and social indicators of the province.
A synthetic Mn <sub>4</sub> Ca-cluster mimicking the oxygen-evolving center of photosynthesis (2015)

Photosynthetic splitting of water into oxygen by plants, algae, and cyanobacteria is catalyzed by the oxygen-evolving center (OEC). Synthetic mimics of the OEC, which is composed of an asymmetric manganese-calcium-oxygen cluster bound to protein groups, may promote insight into the structural and chemical determinants of biological water oxidation and lead to development of superior catalysts for artificial photosynthesis. We synthesized a Mn4Ca-cluster similar to the native OEC in both the metal-oxygen core and the binding protein groups. Like the native OEC, the synthetic cluster can undergo four redox transitions and shows two magnetic resonance signals assignable to redox and structural isomerism. Comparison with previously synthesized Mn3CaO4-cubane clusters suggests that the fourth Mn ion determines redox potentials and magnetic properties of the native OEC.
A method for the isolation of retinal pigment epithelial cells from adult rats. (1993)

This technique enables RPE to be isolated from adult rat in quantities sufficient for biochemical analysis.
Direct load monitoring of rolling bearing contacts using ultrasonic time of flight (2015)

The load applied by each rolling element on a bearing raceway controls friction, wear and service life. It is possible to infer bearing load from load cells or strain gauges on the shaft or bearing housing. However, this is not always simply and uniquely related to the real load transmitted by rolling elements directly to the raceway. Firstly, the load sharing between rolling elements in the raceway is statically indeterminate, and secondly, in a machine with non-steady loading, the load path is complex and highly transient being subject to the dynamic behaviour of the transmission system. This study describes a method to measure the load transmitted directly by a rolling element to the raceway by using the time of flight (ToF) of a reflected ultrasonic pulse. A piezoelectric sensor was permanently bonded onto the bore surface of the inner raceway of a cylindrical roller bearing. The ToF of an ultrasonic pulse from the sensor to the roller–raceway contact was measured. This ToF depends on the speed of the wave and the thickness of the raceway. The speed of an ultrasonic wave changes with the state of the stress, known as the acoustoelastic effect. The thickness of the material varies when deflection occurs as the contacting surfaces are subjected to load. In addition, the contact stiffness changes the phase of the reflected signal and in simple peak-to-peak measurement, this appears as a change in the ToF. In this work, the Hilbert transform was used to remove this contact dependent phase shift. Experiments have been performed on both a model line contact and a single row cylindrical roller bearing from the planet gear of a wind turbine epicyclic gearbox. The change in ToF under different bearing loads was recorded and used to determine the deflection of the raceway. This was then related to the bearing load using a simple elastic contact model. Measured load from the ultrasonic reflection was compared with the applied bearing load with good agreement. The technique shows promise as an effective method for load monitoring in real-world bearing applications.
The application of UV-LEDs to printed circuit board process (2009)

This study investigated using high power UV light emitting diode (LED) to replace the traditional UV lamp in printed circuit board process. It was expected to take the advantages of energy conservation, long life and quick response of UV-LEDs. The feasibility of this replacement was evaluated. There were two kinds of light modules in this work; Type 1 composed of six 1-Watt UV-LEDs arranging as a circle of diameter in 50 mm. Type 2 was equipped with twelve 3-Watt LEDs soldered on a MCPCB of 100 mm in diameter. Both modules emitted a spectrum distribution peaking at a wavelength of 400 nm. The angle of view measuring apparatus was completed for measuring light module angle of view and UV intensity. In order to obtain collimated light source, the parabolic reflectors were used for Type 1. The reflectors showed the six to ten times enhancement of intensity and the improvement of the angle of view from 140° to 30°. In order to approach the practical process, only the original light source was replaced by UV-LED light modules. Other parameters on the automation system remained unchanged. After etching, the patterns were observed and measured by image measurement software. Following the PCB standards, only results with relative errors under 15% were accepted. At present, the minimum reproducible feature size is 75 ¿m by Type 2 light source with 50 mm or 100 mm distance between light source and mask. The results show the feasibility and potential usage of UV-LED in PCB lithography.
Identification of variations of gene expression of visceral adipose and renal tissue in type 2 diabetic rats using cDNA representational difference analysis. (2003)

To identify differences in gene expression in renal and visceral adipose tissue in type 2 diabetic rats using cDNA representational difference analysis (RDA) and to explore the molecular pathogenesis of type 2 diabetes and its chronic vascular complications.A rat model of type 2 diabetes was generated by administration of a high fat and calorie diet combined with a low dose of streptozocin (STZ) injected into the tail vein. The difference bands were generated by cDNA representational difference analysis (cDNA RDA). The final difference products were ligated into the pUC-18 vector and sequenced. A bioformatics analysis was performed on the obtained expressed sequence tags (ESTs), and then the expression levels of known and novel genes were verified by semi-quantitative reverse transcription-PCR (RT-PCR). At the same time, full-length cDNA of a novel gene was cloned in silico.The type 2 diabetic rats in this experiment experienced hyperglycemia, lipidemia, lower insulin sensitivity and normal body weight. We obtained 9 novel ESTs and 2 novel genes from renal tissue of rats and 6 novel ESTs and 1 known gene, the rat lipoprotein lipase (LPL) gene from their visceral adipose tissue. The 2 novel genes (RS91 and RS2) from the renal tissue were both very similar to serine (or cysteine) proteinase inhibitor, clade F and eukaryotic translation initiation factor 3 and subunit 5 (EIF-3 epsilon). The expression of both novel genes and the LPL gene were upregulated in renal and visceral adipose tissue of type 2 diabetic and fat-enriched rats. Full-length cDNA of the novel gene RS91 was cloned in silico.(1) The rat model of type 2 diabetes generated in this study was ideal because the disease in the animals closely mimicked type 2 diabetic patients. (2) cDNA RDA is a flexible, inexpensive, more accurate, sensitive and highly effective technique for identifying differences in gene expression. (3) Six novel ESTs and 1 known gene were obtained from rat visceral adipose tissue. The LPL gene was upregulated in adipose tissue of type 2 diabetic and fat-enriched rats, a result possibly related to the diabetic animals' high fat and calorie diet, lipidemia, insulin resistance (RI) and molecular pathogenesis. (4) Nine novel ESTs and 2 novel genes were obtained from the renal tissue of rat. We believe the 2 novel genes to be the serine proteinase inhibitors clade F and EIF-3 epsilon in rats. The upregulation of the 2 novel genes in renal tissue of type 2 diabetic rats and may have been related to their renal impairment.
World Federation of Neurology Research Group on Dementia (1997)

Amaducci, Luigi; Antuono, Piero; Vice-Chair, ; Boiler, François; Secretary-Treasurer, ; Allegri, Ricardo; Arizaga, Raul; Bick, Katherine; Chandra, Vijai; Henderson, Victor; Ollari, Juan
Heart Allograft Protection with Low-Dose Carbon Monoxide Inhalation: Effects on Inflammatory Mediators and Alloreactive T-cell Responses (2006)

These results show that low dose CO inhalation protects heart allografts and can considerably prolong their survival. CO appears to function via multiple mechanisms, including direct inhibition of Th1 type cytokine production and regulation of inflammatory responses.