gebhart/patrepeval huggingface dataset:
Exploring the Perceptions of College Instructors towards Computer Simulation Software Programs: A Quantitative Study. (2012)

The purpose of the quantitative regression study was to explore and to identify relationships between attitudes toward use and perceptions of value of computer-based simulation programs, of college instructors, toward computer based simulation programs. A relationship has been reported between attitudes toward use and perceptions of the value of simulation learning enhances the use of simulations as a learning tool for college instructors. Previous literature has demonstrated the effectiveness of learning with simulations. Eighty six participants were selected from a national survey bank to complete the Attitudes Toward Using Simulation Instruction Inventory (ASII) questionnaire. A regression analysis was performed determining that the model is linear, the errors have normal distribution (straight line) with frequencies falling inside a 95% confidence level. The independent variable, simulation use, significantly predicted the dependant variables of attitudes and perceptions, p = .04 that is < .05. Simulation use explained a significant proportion of variance in attitudes and perceptions of instructors, F = 3.6 The null hypothesis would be rejected. The dependant variable of frequency of use was not 0. The F - Static for all predictor variables was positive and less than 8.49. Significant relationships exist among the variables. The research showed that positive attitudes and perspectives increase the use of simulations.
Fully Objective Era by Phase Spectral Analysis (1979)

A method of ERA using the Vertex potential is presented which is entirely objective. The result is given by means of a statistical evaluation which is derived automatically. The method is based on pattern analysis of the V-potential, the technique relying essentially on analysis of the phase spectrum of the appropriate Fourier components.
A newly discovered Bordetella species carries a transcriptionally active CRISPR-Cas with a small Cas9 endonuclease (2015)

Expression of the CRISPR-Cas system and processing of crRNAs with perfect homology to prophages present in closely related species, but absent in that containing this CRISPR-Cas system, suggest it provides protection against phage predation. The 3,117-bp cas9 endonuclease gene from this novel CRISPR-Cas system is 990 bp smaller than that of Streptococcus pyogenes, the 4,017-bp allele currently used for genome editing, and which may make it a useful tool in various CRISPR-Cas technologies.
Silicon nano-crystals based MOS memory and effects of traps on charge storage characteristics (2002)

MOS memory device with a silicon nanocrystal based floating gate on a very narrow channel has been fabricated. Large threshold voltage shifts of up to 1V are obtained by applying a small electric field to the tunnel oxide for write/erase operation. Furthermore, charge storage characteristics have been investigated in the MOS diodes, where various interface traps and defects were introduced by thermal annealing treatment.
Impact of mobility on connection in ad hoc networks (2005)

The performance of mobile ad hoc networks is highly sensitive to changes in node-to-node connections (communication links) caused by node movement. Link instability of this kind has proven very difficult to analyze mathematically so previous work has relied heavily on simulation. We present a mathematically tractable model of node motion, the constant velocity model, and use it to derive a precise relation between mobility and connection stability. Our analysis also allows determination of the appropriate frame length for successful and efficient single-hop communication. We further investigate connection stability in multi-hop communication, and uncover some underlying properties of previously proposed mobility metrics. In particular, we demonstrate that link duration has a strong invariant relationship with the stability of multi-hop connections for a wide range of mobility models, and thus is an excellent mobility metric.
Reduction of Serum Cholesterol and Hypercholesterolemic Atherosclerosis in Rabbits by Secoisolariciresinol Diglucoside Isolated From Flaxseed (1999)

Background—Secoisolariciresinol diglucoside (SDG) is a plant lignan isolated from flaxseed. Lignans are platelet-activating factor–receptor antagonists that would inhibit the production of oxygen radicals by polymorphonuclear leukocytes. SDG is an antioxidant. Antioxidants studied thus far are known to reduce hypercholesterolemic atherosclerosis. The objective of this study was to determine the effect of SDG on various blood lipid and aortic tissue oxidative stress parameters and on the development of atherosclerosis in rabbits fed a high-cholesterol diet. Methods and Results—Rabbits were assigned to 4 groups: group 1, control; group 2, SDG control (15 mg · kg body wt−1 · d−1 PO); group 3, 1% cholesterol diet; and group 4, same as group 3 but with added SDG (15 mg · kg body wt−1 · d−1 PO). Blood samples were collected before (time 0) and after 4 and 8 weeks of experimental diets for measurement of serum triglycerides, total cholesterol (TC), and LDL, HDL, and VLDL cholesterol (LDL-C, HDL-C, and VLDL-C). T...
Methyl CpG–binding proteins induce large-scale chromatin reorganization during terminal differentiation (2005)

Pericentric heterochromatin plays an important role in epigenetic gene regulation. We show that pericentric heterochromatin aggregates during myogenic differentiation. This clustering leads to the formation of large chromocenters and correlates with increased levels of the methyl CpG-binding protein MeCP2 and pericentric DNA methylation. Ectopic expression of fluorescently tagged MeCP2 mimicked this effect, causing a dose-dependent clustering of chromocenters in the absence of differentiation. MeCP2-induced rearrangement of heterochromatin occurred throughout interphase, did not depend on the H3K9 histone methylation pathway, and required the methyl CpG-binding domain (MBD) only. Similar to MeCP2, another methyl CpG-binding protein, MBD2, also increased during myogenic differentiation and could induce clustering of pericentric regions, arguing for functional redundancy. This MeCP2- and MBD2-mediated chromatin reorganization may thus represent a molecular link between nuclear genome topology and the epigenetic maintenance of cellular differentiation.
Quantitative Relations Between Chromatin and Cytoplasm in the Genus Arcella, with their Relations to External Characters (1919)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Simultaneous speculative threading (2009)

This paper presents Simultaneous Speculative Threading (SST), which is a technique for creating high-performance area- and power-efficient cores for chip multiprocessors. SST hardware dynamically extracts two threads of execution from a single sequential program (one consisting of a load miss and its dependents, and the other consisting of the instructions that are independent of the load miss) and executes them in parallel. SST uses an efficient checkpointing mechanism to eliminate the need for complex and power-inefficient structures such as register renaming logic, reorder buffers, memory disambiguation buffers, and large issue windows. Simulations of certain SST implementations show 18% better per-thread performance on commercial benchmarks than larger and higher-powered out-of-order cores. Sun Microsystems' ROCK processor, which is the first processor to use SST cores, has been implemented and is scheduled to be commercially available in 2009.
α,β-Unsaturated Carboxylic Acid Derivatives. IX. The Cyclization of α-(<i>N</i>-Acyl-hydroxyamino) Acid Esters with Ammonia or Hydroxylamine (1975)

Abstract A new type of cyclization reaction of α-(N-acyl-hydroxyamino) acid esters to imidazolidine-4-one derivatives and the synthesis of several 2,5-piperazinedione derivatives are described. The treatment of β-methoxy-α-(N-chloroacetyl- or N-phthaloylglycyl-hydroxyamino) acid esters with ammonia gave 2-carbamoyl-2-(1-methoxy)alkyl-or aralkyl-imidazolidine-4-ones, while a similar cyclization of α-(N-haloacetylamino) or α-(N-haloacyl-hydroxyamino) acid esters with ammonia or hydroxylamine gave 2,5-piperazinedione, 1-hydroxy-2,5-piperazinedione or 1,4-dihydroxy-2,5-piperazinedione derivatives. The difference in the formation mechanisms between the imid-azolidine-4-one and 2,5-piperazinedione and their structural assignment were discussed.
Reduced Culture Temperature Differentially Affects Expression and Biophysical Properties of Monoclonal Antibody Variants (2014)

Reduced culture temperature is an increasingly popular practice to improve recombinant protein yields in CHO cells. Recent studies have attributed the enhancement of protein titers at sub-physiological temperatures to increased mRNA levels as well as extended stationary phase. We observed that reducing the culture temperature arrested cell growth, prolonged viability, and increased cell size. However, the reduced culture temperature had a differential effect on protein and mRNA expression of closely related antibody mutants from stable cell lines. The highly expressing mutant (Ala) exhibited similar or decreased specific productivity and decreased volumetric productivity over the culture lifetime at 32 °C compared to 37 °C. In contrast, the specific and volumetric productivity of the poorly expressing mutant (Gly) was enhanced at the lower culture temperature. The difference in specific productivity was reflected in the amounts of heavy- and light-chain mRNA. Analysis of the secondary and tertiary configurations of the purified antibodies by circular dichroism revealed fundamental structural differences imposed by the Ala to Gly mutation as well as reduced culture temperature. We propose that the effect of reduced culture temperature on expression is protein-dependent; protein folding fidelity and assembly is improved at lower temperatures, enhancing the expression of proteins that have a propensity to misfold.
Sugar-mediated lattice contacts in crystals of a plant glycoprotein (2002)

Pokeweed antiviral protein, PAP-S(aci), isolated from seeds of the Chinese pokeweed plant, Phytolacca acinosa, belongs to the family of type-1 ribosome-inactivating proteins (RIPs). Type-1 RIPs are approximately 30-kDa N-glycosidases that inactivate eukaryotic and prokaryotic ribosomes via a site-specific depurination of ribosomal RNA (rRNA). Here we describe the preliminary X-ray structure determination at 1.7 A resolution of one PAP isoenzyme from seeds, PAP-S1(aci), after crystallisation from a heterogeneous mixture of two isoenzymes. PAP-S1(aci) possesses a rare type of glycosylation, specifically, N-linked N-acetyl-D-glucosamine monosaccharide (GlcNAc) substitutions at canonical Asn-Xaa-Ser/Thr sequons. One GlcNAc residue was found to play a critical role in crystal lattice formation, forming a packing interface across a crystallographic two-fold with the identical sequon of an adjacent monomer. This observation suggests that deglycosylation protocols for the crystallisation of glycoproteins should be designed to allow for exploitation of the crystal packing potential of the innermost core sugar residue (N-linked GlcNAc or O-linked GalNAc).
GPS System Integration and Field Approaches in Precision Farming (1994)

Two phases of a precision farming project are described. Phase I consists of the collection of data from four test fields across Alberta using differential GPS (DGPS) combined with crop yield monitors and electromagnetic (EM) ground conductivity meters for measuring salinity. A geographic information system (GIS) is used to analyze and combine various layers of information obtained from each field in order to analyze yield variation. Positions better than 50 cm horizontally and 1 m vertically are obtained in DGPS mode using a robust carrier-phase smoothing of the code approach. The accuracy of the DGPS positions is verified independently through a crossover point analysis and a comparison with an ambiguity resolution on the fly (OTF) solution. DGPS positions are used to generate maps, which indicate that fields are not homogeneous in crop yield when they have been treated without consideration for variability of soil, salinity, topography, or field history. Phase II, which consists of the application of variable-rate fertilizer based on the information gathered in Phase I, is summarized.
Synthesis and properties evaluation of β-SiAlON prepared by mechanical alloying followed by different sintering technique (2016)

Abstract In this study, sintering was investigated for making SiAlON by utilizing low cost Si 3 N 4 , Al 2 O 3 and AlN powder precursors. These materials were mixed by mechanical ball milling, then processed by pressureless sintering or spark plasma sintering methods and the properties compared. XRD spectroscopy showed nano-scale and amorphous phases, which were produced after longer milling time. Investigation of the bulks after sintering revealed that increasing the pressureless sintering temperature resulted in an increase in density and mechanical properties of the specimens, as did changing the sintering technique from pressureless to spark plasma sintering. Furthermore, the wear mechanisms of adhesive or micro-abrasion of the rubbed surfaces were confirmed.
Evaluation of Equivalent Spring Stiffness for Use in a Pseudo-Rigid-Body Model of Large-Deflection Compliant Mechanisms (1996)

Compliant mechanisms gain some or all of their mobility from the flexibility of their members rather than from rigid-body joints only. More efficient and usable analysis and design techniques are needed before the advantages of compliant mechanisms can be fully utilized. In an earlier work, a pseudo-rigid-body model concept, corresponding to an end-loaded geometrically nonlinear, large-deflection beam, was developed to help fulfill this need. In this paper, the pseudo-rigid-body equivalent spring stiffness is investigated and new modeling equations are proposed. The result is a simplified method of modeling the force/deflection relationships of large-deflection members in compliant mechanisms. The resulting models are valuable in the visualization of the motion of large-deflection systems, as well as the quick and efficient evaluation and optimization of compliant mechanism designs.
Composition-Dependent Basics of Smart Heusler Materials from First- Principles Calculations (2011)

The structural and magnetic order are the decisive elements which vastly determine the properties of smart ternary intermetallics such as X2YZ Heusler alloys. Here, X and Y are transition metal elements and Z is an element from the III-V group. In order to give a precise prescription of the possibilities to optimize the magnetic shape memory and magnetocaloric effects of these alloys, we use density functional theory calculations. In particular, we outline how one may find new intermetallics which show higher Curie and martensite transformation temperatures when compared with the prototypical magnetic shape-memory alloy Ni2MnGa. Higher operation temperatures are needed for technological applications at elevated temperatures.
Developing a Slow-release Nitrogen Fertilizer from Organic Sources: I. Using Nonviable Bacteria (1996)

Mineralization of N from nonviable cells of Brevibacterium lactofermentum (Okumura et al.) mixed into soilless substrate in elution columns occurred largely during the first 5 weeks with a peak between 2 and 3 weeks. Over a 12-week period, 73% of the total N was recovered in the eluent. To prolong the period of N release to meet the requirements of a slow-release fertilizer, the bacterium was bonded to kraft lignin, a polyphenolic substance highly resistant to degradation. To retard mineralization further, the bacterium-lignin mixture was reacted with formaldehyde to form amino cross-links within and between protein chains. Bonding to lignin was undesirable because N release occurred during the same period as from the bacteria unbound to lignin and the total amount of N recovered was reduced to only 42%. Cross-linking with formaldehyde was less desirable since N was released mainly during the first 4 weeks with a peak during the first elution (0 time) and the total amount of N released was even lower than for the bacterium-lignin mixture. Additions of urea to the latter reaction did not satisfactorily improve subsequent N mineralization. In a second set of treatments lignin was withheld and the bacterium was reacted with weights of formaldehyde (a.i.) equivalent to 0.1%, 0.5%, 1.0%, 5.0%, and 10.0% of the dry weight of bacterium. Formaldehyde quantities ≤1.0% either had no effect or lowered the mineralization of N without altering time of release. Five percent and 10% formaldehyde successfully reduced release of N during the first 4 weeks and increased it thereafter. The best rate was 5%. In this treatment N was released from week 2 through the end of the test (12 weeks). Peak release occurred at 6 weeks. This resulting N source, while not a stand alone product, does have a slow-release property that could lend itself to use in combination with other slow-release N sources.
Role of type 1 fimbriae in the pathogenesis of ascending urinary tract infection induced by escherichia coli in mice (1983)

Escherichia coli mutants defective in the ability to agglutinate guinea pig erythrocytes (HA-) were isolated from a nalidixic acid-resistant derivative, 31-B, of E. coli TN 675 that produces type 1 fimbriae and induces urinary tract infection in mice fed a 5% glucose solution. All nine HA- mutants were defective not only in their ability to agglutinate Candida albicans cells and erythrocytes from various species, but also in their capacity to adhere to mouse bladder epithelial cells. None of the mutants were agglutinated by anti-type 1 fimbriae antiserum. Although most of the mutants were fimbriated when examined by electron microscopy, their fimbriae differed serologically from type 1 fimbriae. All of the mutants showed 100 to 1,000 times lower bacterial recovery from the bladder walls of mice 3 h after inoculation into the bladder and lacked urinary tract infectivity in mice. These results suggest that all of the HA- mutants are defective in type 1 fimbriae production and that type 1 fimbriae facilitate the development of urinary tract infection in mice, probably by mediating bacterial adherence to the bladder epithelial cells.
Neonatal pulmonary artery banding does not compromise the short-term function of a Damus–Kaye–Stansel connection (2000)

This experience demonstrates that a neonatal pulmonary artery banding does not compromise the function neither of a Damus-Kaye-Stansel connection nor a Fontan repair.
Tailoring the Particle Size Distribution in Suspension Polymerization of Poly(MMA‐co‐EGDMA): Role of Stabilizer and Agitation Rate (2017)

In suspension polymerization, the particle size distribution plays important role since it determines the application and process ability of final product. However, the particle size distribution (PSD) can be controlled by varying operating parameters and this can improve the quality of final product. Herein, the present work focuses on role of stabilizer concentration and agitation speed on controlling PSD in suspension polymerization of crosslinked porous poly(methylmethacrylate‐co‐ethyleneglycoldimethacrylate) p(MMA‐co‐EGDMA).By controlling these two parameters particle size distribution results in in the range of 500–841 μm which is desirable for various industrial applications. The percent yield of particles falling in the range of 500–841 μm was found 73 ± 1.0% at PVA concentration 2% w/v and at agitation rate of 220 rpm. The Sauter mean diameter has also been evaluated. As PVA concentration and agitation rate increased, mean drop size decreased and PSD became narrower which led to reducing the Sauter mean diameter. The experimental results reveal that by controlling only two parameters the desirable PSD could be obtained.
The Dopamine Transporter Constitutively Internalizes and Recycles in a Protein Kinase C-regulated Manner in Stably Transfected PC12 Cell Lines (2003)

The dopamine transporter (DAT) removes dopamine from the extracellular milieu and is potently inhibited by number of psychoactive drugs, including cocaine, amphetamines, and methylphenidate (Ritalin). Multiple lines of evidence demonstrate that protein kinase C (PKC) down-regulates dopamine transport, primarily by redistributing DAT from the plasma membrane to endosomal compartments, although the mechanisms facilitating transporter sequestration are not defined. Here, we demonstrate that DAT constitutively internalizes and recycles in rat pheochromocytoma (PC12) cells. Temperature blockades demonstrated basal internalization and reliance on recycling to maintain DAT cell surface levels. In contrast, recycling blockade with bafilomycin A1 significantly decreased transferrin receptor (TfR) surface expression but had no effect on DAT surface levels, suggesting that DAT and TfR traffic via distinct endosomal mechanisms. Kinetic analyses reveal robust constitutive DAT cycling to and from the plasma membrane, independent of transporter expression levels. In contrast, phorbol ester-mediated PKC activation accelerated DAT endocytosis and attenuated transporter recycling in a manner sensitive to DAT expression levels. These data demonstrate constitutive DAT trafficking and that PKC-mediated DAT sequestration is achieved by a combination of accelerated internalization and reduced recycling. Additionally, the differential sensitivity to expression level exhibited by constitutive and regulated DAT trafficking suggests that these two processes are mediated by independent cellular mechanisms.
摄影机是我的演员——访奥利弗·斯通 (1994)

人们渴望了解真相。——吉姆·加里森(凯文·科斯 特纳饰,引自影片《J·F·K·》[又译《刺杀肯尼迪》]) 在当今的年代,一个优秀的电影导演每拍一部影片要花去两年的时间,因此奥利弗·斯通可以当之无愧地被认为是电影界最勤奋的导演:七年拍了八部故事片(其中三部是史诗片),另有一部新片——《天生杀手》(NaturalBorn Killers)——正在进行后期剪辑制作,准备在1994年发行。但是他是不是工作得太苦了?自从拍完《野战排》(1986)以后,有那么一段时间,他一部接一部地拍片,结果拍出的作品从创作和观念上似乎让人感到喘不过气来。斯
Phosphorus- and arsenic-bridged [1]ferrocenophanes. 3. Hydroformylationcatalyzed by the products of the interaction of Co2(CO)8 with 1,1'-ferrocenylenephenylphosphine oligomers and polymers (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphorus- and arsenic-bridged [1]ferrocenophanes. 3. Hydroformylationcatalyzed by the products of the interaction of Co2(CO)8 with 1,1'-ferrocenylenephenylphosphine oligomers and polymersJere D. Fellmann, Philip E. Garrou, Howard P. Withers, Dietmar Seyferth, and Daniel D. TraficanteCite this: Organometallics 1983, 2, 7, 818–825Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/om50001a007https://doi.org/10.1021/om50001a007research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts