gebhart/patrepeval huggingface dataset:
Porphyromonas gingivalis SerB-mediated dephosphorylation of host cell cofilin modulates invasion efficiency (2011)

Porphyromonas gingivalis, a host-adapted opportunistic pathogen, produces a serine phosphatase, SerB, known to affect virulence, invasion and persistence within the host cell. SerB induces actin filament rearrangement in epithelial cells, but the mechanistic basis of this is not fully understood. Here we investigated the effects of SerB on the actin depolymerizing host protein cofilin. P. gingivalis infection resulted in the dephosphorylation of cofilin in gingival epithelial cells. In contrast, a SerB-deficient mutant of P. gingivalis was unable to cause cofilin dephosphorylation. The involvement of cofilin in P. gingivalis invasion was determined by quantitative image analysis of epithelial cells in which cofilin had been knocked down or knocked in with various cofilin constructs. siRNA-silencing of cofilin led to a significant decrease in numbers of intracellular P. gingivalis marked by an absence of actin colocalization. Transfection with wild-type cofilin or constitutively active cofilin both increased numbers of intracellular bacteria, while constitutively inactive cofilin abrogated invasion. Expression of LIM kinase resulted in reduced P. gingivalis invasion, an effect that was reversed by expression of constitutively active cofilin. These results show that P. gingivalis SerB activity induces dephosphorylation of cofilin, and that active cofilin is required for optimal invasion into gingival epithelial cells.
Thermal effects in microfluidics with thermal conductivity spatially modulated (2014)

A heat transfer model on a microfluidic is resolved analytically. The model describes a fluid at rest between two parallel plates where each plate is maintained at a differentially specified temperature and the thermal conductivity of the microfluidic is spatially modulated. The heat transfer model in such micro-hydrostatic configuration is analytically resolved using the technique of the Laplace transform applying the Bromwich Integral and the Residue theorem. The temperature outline in the microfluidic is presented as an infinite series of Bessel functions. It is shown that the result for the thermal conductivity spatially modulated has as a particular case the solution when the thermal conductivity is spatially constant. All computations were performed using the computer algebra software Maple. It is claimed that the analytical obtained results are important for the design of nanoscale devices with applications in biotechnology. Furthermore, it is suggested some future research lines such as the study of the heat transfer model in a microfluidic resting between coaxial cylinders with radially modulated thermal conductivity in order to achieve future developments in this area.
1000 and 1500 volts planar devices using field plate and semi-resistive layers: design and fabrication (2002)

An improved high-voltage technique based on the use of a field plate combined with semiresistive layers (SIPOS) on oxide is proposed. The field plate and SIPOS are shown to have complementary functions. Junction curvature electric field effects are reduced by the presence of the field plate. The silicon surface potential is linearized by a primary SIPOS layer on oxide, thereby reducing the peak electric field at the edge of the field plate. A second high-resistivity SIPOS layer provides excellent passivation. The use of SIPOS as both a field-linearizing film and passivation permits completion of all chemical vapor depositions in a single reactor run. The complete design and fabrication of high-voltage (1000 and 1500 V) planar transistors are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Upgrade of operating range for SULTAN test facility (2002)

The German SUpraLeiterTest ANlage (SULTAN) test facility at the Centre de Recherches en Physique des Plasma (CRPP), Villigen, is a worldwide unique tool to test high current superconductors over a broad range of operating conditions. The key component of the facility is a set of forced flow superconducting coils to generate a background field up to 11 T. A flux pump supplies the test sample with current up to 100 kA. A set of pulsed coils generates a transverse, time varying field, with amplitude up to 4 T and field rate up to 65 T/s. The instrumentation and the data acquisition system allow accurate measurements of the dc behavior, ac losses, transient stability, current distribution. A clear definition of the interface between facility and users gives flexible and easy access to external scientists with minimum time requirement for sample replacement. The experiments from the last five years of operation contributed to the progress in understanding design issues for large cable-in-conduit conductors, including quench propagation, copper segregation, coupling loss, joint, stability, and cyclic load.
Split timing mode (STM)-answer to dual frequency domain testing (2002)

This paper describes Split Timing Mode (STM), a dual timing domain ATE architecture, which allows selected channels to run at a different frequency from others. The paper also details the timing, pattern and datalogging details of STM, with examples to show how it can make it easier for the test engineer to develop and debug tests for these classes of devices.
Off-Road Lidar Simulation with Data-Driven Terrain Primitives (2018)

Developing software for large scale off-road robot applications is challenging and tedious due to cost, logistics, and rigor of field testing. High-fidelity sensor-realistic simulation can speed up the development process for perception and state estimation algorithms. We focus on Lidar simulation for robots operating in off-road environments. Lidars are integral sensors for robots, and Lidar simulation for off-road environments is particularly challenging due to the way Lidar rays interact with natural terrain such as vegetation. A hybrid geometric terrain representation has been shown to model Lidar observations well [1]. However, previous work has only been able to simulate a single, fixed scene, and the entire scene had to be precisely surveyed. In this work, we add semantic information to the hybrid geometric model. This allows us to extract terrain primitives, such as trees and shrubs, from data logs. Our approach uses these primitives to compose arbitrary scenes for Lidar simulation. We evaluate our simulator on a real-world environment of interest, and show that primitives derived using our approach generalize to new scenes.
Silole-spaced triarylamine derivatives as highly efficient organic sensitizers in dye-sensitized solar cells (DSSCs) (2010)

Three new organic dyes that contain the dithienosilole (DTS) moiety as spacer have been synthesized and their photophysical/electrochemical properties, theoretical calculation and dye-sensitized solar cell (DSSC) performance have been investigated. The overall conversion efficiencies for DSSCs based on these dyes range from 6.73 to 7.50%, comparable to a (3–5′-[N,N-bis(9,9-dimethylfluorene-2-yl)phenyl]2,2′-bithiophene-5-yl}-2-cyanoacrylic acid (JK-2)-sensitized device (7.63%), fabricated and measured under the same experimental conditions. The DSSC constructed from one of the three compounds shows a higher open-circuit voltage (VOC) compared to those of the other two dye sensitized solar cells due to an increased electron lifetime (τe) in the conduction band of TiO2.
A First Principles Study of H2 Adsorption on LaNiO3(001) Surfaces (2017)

The adsorption of H₂ on LaNiO₃ was investigated using density functional theory (DFT) calculations. The adsorption sites, adsorption energy, and electronic structure of LaNiO₃(001)/H₂ systems were calculated and indicated through the calculated surface energy that the (001) surface was the most stable surface. By looking at optimized structure, adsorption energy and dissociation energy, we found that there were three types of adsorption on the surface. First, H₂ molecules completely dissociate and then tend to bind with the O atoms, forming two -OH bonds. Second, H₂ molecules partially dissociate with the H atoms bonding to the same O atom to form one H₂O molecule. These two types are chemical adsorption modes; however, the physical adsorption of H₂ molecules can also occur. When analyzing the electron structure of the H₂O molecule formed by the partial dissociation of the H₂ molecule and the surface O atom, we found that the interaction between H₂O and the (001) surface was weaker, thus, H₂O was easier to separate from the surface to create an O vacancy. On the (001) surface, a supercell was constructed to accurately study the most stable adsorption site. The results from analyses of the charge population; electron localization function; and density of the states indicated that the dissociated H and O atoms form a typical covalent bond and that the interaction between the H₂ molecule and surface is mainly due to the overlap-hybridization among the H 1s, O 2s, and O 2p states. Therefore, the conductivity of LaNiO₃(001)/H₂ is stronger after adsorption and furthermore, the conductivity of the LaNiO₃ surface is better than that of the LaFeO₃ surface.
A Miniaturized Phased Array Antenna Based on Novel Switch Line Phase Shifter Module (2019)

A miniaturized phased array antenna with a uniquely designed switch line phase shifter to obtain a steerable beam pattern is presented. A 1x4 phased array patch antenna is designed at 5 GHz using Rogers dielectric material with a relative permittivity of 6.15 and a thickness of 1.524 mm. Each element of the probe fed PAA are connected to a phase shifter on a different dielectric substrate. The phase shifter has four equal length microstrip lines placed in a circular fashion around a via that connects to the antenna at the center. The addition of each microstrip line is designed to provide a phase shift of 90⁰. This design provides the ability to place the phase shifter and feed to the antenna in space constrained locations. The maximum steering angle obtained was ±45⁰. This design is appropriate for Wi-Fi applications that requires directional beam pattern, Multiple Input Multiple Output (MIMO) communications, scanning radars, and other applications requiring steerable beam pattern. This design is patent pending.
Front Line Demonstrations on Integrated Management of Betelvine Leaf and Foot Rot, Phytophthora capsici (2012)

Phytophthora leaf and foot rot (Phytophthora capsici, Leonain) of betelvine is the most serious disease causing considerable yield losses in traditional betelvine growing areas. Integrated disease management (IDM) technology developed by All India Coordinated Research Project on betelvine, Bapatla centre was demonstrated in farmers’ fields from 2003–2004 to 2009–10 in major betelvine growing villages of Guntur district of Andhra Pradesh in comparison with the farmers’ practice. The IDM package consisting of sanitation, application of Bordeaux mixture (1% soil drench) and bioagent @ 5 kg/ha (Trichoderma viride) after its multiplication on neem cake, followed by second application of Bordeaux mixture with a gap of 30-day interval between each application. IDM technology reduced the Phytophthora foot rot incidence (40.8%) and leaf rot index (55.8%) over the farmer's practice, with increased yield of 22.1% with cost benefit ratio of 1: 2.38. The farmers were convinced with the new technology and got benefited by adopting the IDM technology, which extended life of the garden yielding more returns.
Construction of Regulated Nanospace around a Porphyrin Core (2001)

A series of 1,3,5-phenylene-based rigid dendritic porphyrins were synthesized by Suzuki coupling between a porphyrin core and dendron units. The intramolecular energy transfer was studied by absorption and fluorescence spectroscopies. The encapsulation of the porphyrin core within the 1,3,5-phenylene dendron units was found to provide highly efficient energy transfer from the dendron units to the porphyrin core. The dendritic wedge structure affected the energy transfer efficiency. The 1,3,5-phenylene-based rigid dendron units act as highly efficient light-harvesting antennae. These dendritic porphyrins have also been examined as C(60) hosts and substrate-selective oxidation catalysts. The attachment of the second generation of 1,3,5-phenylene-based dendron units with the porphyrin core enabled a stable inclusion of C(60) in toluene. Furthermore, the size and shape of the nanospace in the rigid dendritic porphyrins were found to affect the selectivity of substrates in the catalytic olefin oxidations.
The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity (2016)

The repertoire of peptides displayed in vivo by MHC II molecules derives from a wide spectrum of proteins produced by different cell types. Although intracellular endosomal processing in dendritic cells and B cells has been characterized for a few antigens, the overall range of processing pathways responsible for generating the MHC II peptidome are currently unclear. To determine the contribution of non-endosomal processing pathways, we eluted and sequenced over 3000 HLA-DR1-bound peptides presented in vivo by dendritic cells. The processing enzymes were identified by reference to a database of experimentally determined cleavage sites and experimentally validated for four epitopes derived from complement 3, collagen II, thymosin β4, and gelsolin. We determined that self-antigens processed by tissue-specific proteases, including complement, matrix metalloproteases, caspases, and granzymes, and carried by lymph, contribute significantly to the MHC II self-peptidome presented by conventional dendritic cells in vivo. Additionally, the presented peptides exhibited a wide spectrum of binding affinity and HLA-DM susceptibility. The results indicate that the HLA-DR1-restricted self-peptidome presented under physiological conditions derives from a variety of processing pathways. Non-endosomal processing enzymes add to the number of epitopes cleaved by cathepsins, altogether generating a wider peptide repertoire. Taken together with HLA-DM-dependent and-independent loading pathways, this ensures that a broad self-peptidome is presented by dendritic cells. This work brings attention to the role of "self-recognition" as a dynamic interaction between dendritic cells and the metabolic/catabolic activities ongoing in every parenchymal organ as part of tissue growth, remodeling, and physiological apoptosis.
A stacked capacitor technology with ECR plasma MOCVD (Ba,Sr)TiO/sub 3/ and RuO/sub 2//Ru/TiN/TiSi/sub x/ storage nodes for Gb-scale DRAMs (1997)

A Gb-scale DRAM stacked capacitor technology with (Ba,Sr)TiO/sub 3/ thin films is described, The four-layer RuO/sub 2//Ru/TiN/TiSi/sub x/, storage node configuration allows 500/spl deg/C processing and fine-patterning down to the 0.20 /spl mu/m size by electron beam lithography and reactive ion etching. Good insulating (Ba/sub 0.4/Sr/sub 0.6/)TiO/sub 3/ (BST) films with an SiO/sub 2/ equivalent thickness of 0.65 nm on the electrode sidewalls and leakage current of 1/spl times/10/sup -/6 A/cm/sup 2/ at 1 V are obtained by ECR plasma MOCVD without any post-deposition annealing, A lateral step coverage of 50% for BST is observed on the 0.2 /spl mu/m size storage node pattern, and the BST thickness on the sidewalls is very uniform, thanks to the ECR downflow plasma. Using this stacked capacitor technology, a sufficient cell capacitance of 25 fF for 1 Gb DRAMs can be achieved in a capacitor area of 0.125 /spl mu/m/sup 2/ with only the 0.3 /spl mu/m high-storage electrodes.
Phase Diagram of the System KF–AlF <sub>3</sub> (2000)

The system KF–AlF 3 was reinvestigated precisely by differential thermal analysis, X‐ray diffractometry, and visual observation. All of the samples for the present investigation were prepared by solution synthesis. The results verified the existence of 2KF·AlF 3 (K 2 AlF 5 ) and KF·4AlF 3 in the phase diagram; both compounds were orthorhombic. The cell parameters of the compounds were, respectively, a = 10.87 ± 0.03 Å, b = 10.36 ± 0.01 Å, c = 7.83 ± 0.03 Å, and a = 7.89 ± 0.01 Å, b = 7.57 ± 0.01 Å, c = 6.94 ± 0.01 Å. KAlF 4 was confirmed to melt congruently at 575°± 2°C by careful examination.
New Magnetically Ordered Materials with High T<sub>c</sub> (1993)

Abstract Magnets comprised of molecules, ions, and polymers is a focus of contemporary materials science research. The anticipated attributes of organic/molecular-based magnetic materials may enable their use in future generations of electronic, magnetic and/or photonic/photronic devices. Some organometallic solids comprising linear chains of alternating metallocenium donors, D, and cyanocarbon acceptors, A, i. e., -D-+A D+A, exhibit cooperative magnetic phenomena, i. e., ferro-, antiferro-, ferri-, and metamagnetism. For [FeIII(C5Me5)2]-+[TCNE] - (Me = methyl; TCNE = tetracyanoethylene) bulk ferromagnetic behavior is observed below the critical (Curie) temperature, Tc, of 4.8 K. Replacement of FeIII with MnIII leads to a ferromagnet with a Tc of 8.8 K in agreement with mean-field models developed for this class of materials. Extension to the reaction of a vanadium(0) complex with TCNE lead to the isolation of a magnet with a Tc ∼ 400 K which exceeds the thermal decomposition of the material. A new class of metalloporphins exhibiting magnetic order are also reported. This demonstrates that a magnetic material with a Tc substantially above room temperature is achievable in a molecule/organic/polymeric material.
Survey of Safety Management Approaches to Unmanned Aerial Vehicles and Enabling Technologies (2018)

Unmanned aerial vehicle (UAV) has a rapid development over the last decade. However, an increasing number of severe flight collision events caused by explosive growth of UAV have drawn widespread concern. It is an important issue to investigate safety management approaches of UAVs to ensure safe and efficient operation. In this paper, we present a comprehensive overview of safety management approaches in large, middle and small scales. In large-scale safety management, path-planning problem is a crucial issue to ensure safety and ordered operation of UAVs globally. In middle-scale safety management, it is an important issue to study the conflict detection and resolution methods. And in small-scale safety management, real-time collision avoidance is the last line of ensuring safety. Moreover, a UAV can be regarded as a terminal device connected through communication and information network. Therefore, the enabling technologies, such as sensing, command and control communication, and collaborative decision-making control technology, have been studied in the last.
Variations in middle cerebral artery blood flow investigated with noninvasive transcranial blood velocity measurements. (1987)

Observations on blood velocity in the middle cerebral artery using transcranial Doppler ultrasound and on the ipsilateral internal carotid artery flow volume were obtained during periods of transient, rapid blood flow variations in 7 patients. Five patients were investigated after carotid endarterectomy. A further 2 patients having staged carotid endarterectomy and open heart surgery were investigated during nonpulsatile cardiopulmonary bypass. The patient selection permitted the assumption that middle cerebral artery flow remained proportional to internal carotid artery flow. The integrated time-mean values from consecutive 5-second periods were computed. The arithmetic mean internal carotid artery flow varied from 167 to 399 ml/min in individual patients, with individual ranges between +/- 15% and +/- 35% of the mean flow. The mean middle cerebral artery blood velocity varied from 32 to 78 cm/sec. The relation between flow volume and blood velocity was nearly linear under these conditions. Normalization of the data as percent of the individual arithmetic means permitted a composite analysis of data from all patients. Linear regression of normalized blood velocity (V') on normalized flow volume (Q') showed V' = 1.05 Q' - 5.08 (r2 = 0.898).
Boron Subphthalocyanine Dyes: 3-Pentadecylphenol as a Solubilizing Molecular Fragment (2011)

We report the synthesis and characterization of a series of boronsubphthalocyanine (BsubPc) dyes which have organic solubility >10–2 M while being amenable to doping into polymeric films. To achieve high solubility we have placed the 3-pentadecylphenoxy molecular fragment in a variety of positions within the BsubPc chemical structure including around the periphery of the BsubPc ligand and in the axial position to the boron atom. We have found that placement of the 3-pentadecylphenoxy molecular fragment around the periphery adversely affects the photostability of the resulting BsubPc whereas placement in the axial position has little effect. We also confirm that the presence of fluorine atoms around the periphery improves the photostability. Overall we present a systematic study of the 3-pentadecylphenoxy fragment as a solubilizing moiety for BsubPc. The nature of the substituents and their position does not affect the nearly pure magenta color characteristic of BsubPc derivatives.
Physicochemical analysis of nucleobase-metal interactions (2002)

It is important to know what kinds of chemical bonds are formed between metal ions and nucleic acids. We have studied metal-nucleobase interactions, by using NMR spectroscopy in solution. For the accurate understanding, we tried measurement at low temperature below -30 degrees C. To avoid freezing of the solution, we have extensively searched solution conditions which is suitable for measurements at low temperature, and found several possible conditions. One was the condition which contained H2O and cryoprotectant at low pH for guanosine-5'-monophosphate--Cd(II), system, the other was the mixed solvent of dimethyl sulfoxide and N,N-dimethylformamide for guanosine--Cd(II) system.
The nucleotide sequence of the promoter, 16S rRNA and spacer region of the ribosomal RNA operon of Mycobacterium tuberculosis and comparison with Mycobacterium leprae prefnsor rRNA (1992)

Mycobacterium tuberculosis H37Rv has a single rrn (ribosomal RNA) operon. The operon was cloned and a region of 1536 nucleotides was sequenced, starting 621 bp upstream from the 5'-end of the 16S rRNA coding region and continuing to the start of the 23S rRNA coding region. The 16S rRNA sequence inferred from the gene sequence was found to differ in one position from Mycobacterium bovis (nucleotide 1443) and from Mycobacterium microti (nucleotide 427). A single putative promoter was identified on the basis of similarities with the sequence of rrn operons of Bacillus subtilis and Escherichia coli. The regions of similarity include a -35 box, a -10 box, a stringent response element, antitermination signals, potential RNAase III processing sites and features of precursor rRNA secondary structure. Sequences upstream from the 5'-end of Mycobacterium leprae 16S rRNA were also investigated. Homologous schemes of secondary structure were deduced for precursor rRNA of both M. tuberculosis and M. leprae; although the principal features are common to both species there are notable differences.