gebhart/patrepeval huggingface dataset:
A new SOL fabrication technique for ultrathin active layer of less than 80 nm (1990)

A silicon-on-insulator (SOI) technique has been developed for fabricating thin-film SOI transistors. Ultrathin high-quality SOI less than 80 nm thick has been produced by the technique, which was named HO/SOI (Hollowed-Out SOI). A submicron p-MOSFET has been formed by this technique. The transconductance g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> of the SOI MOSFET is 0.75 mS/mm at a gate voltage of -5 V and a drain voltage of -0.05 V. The g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> is 47% higher than that of a bulk MOSFET. Negative differential conductance was observed for the p-MOSFET, as had been previously observed in n-MOSFET. The technique makes it possible to control the thermal oxide thickness of back gates, and eliminate leakage on the back surface of an SOI. This leads to the SOI transistor controlled by both side gates, or upside gate and bottom side gate
Nonspecific urethritis in females. (1970)

The possibility of nonspecific urethritis must be considered in females with persistent irritative symptoms of the lower urinary tract despite "negative" urine cultures. The diagnosis can be made only by the proper collections of urine specimens from both the urethra and the bladder. These specimens will reveal the presence of white blood cells in the urethral washings, while the midstream (bladder) specimen will be free of cells.
A proposal of a vacuum micro quantum interference transistor (1993)

A quantum interference transistor that can be fabricated by available technology and can operate at room temperature is proposed. This device uses the phase interference effect of a vacuum electron that is not influenced by thermal fluctuations, in contrast to an electron in solid-state materials. The device consists of a field emitter, a collector, and segmented capacitors between the emitter and the collector. The capacitors control electron trajectories and the phase interference of the electron in vacuum by their electrical potential. This quantum interference effect is found not to be the same as the Aharonov–Bohm effect contrary to our expectations. We are convinced that the new transistor is capable of room-temperature operation because the large kinetic energy of the electron in vacuum suppresses energy fluctuations caused by the field emission itself and by thermal fluctuations in the emitter material to about 50 meV. The switching time of the transistor is limited in order to average the number of electrons at the collector to allow the emitter-collector current to be a deterministic variable against the quantum stochastic property. The threshold of the switching time is estimated to be of the order of magnitude of 10−11 s for the field emitter reported by C. A. Spindt, I. Brodie, L. Hummphrey, and E. R. Westerberg [J. Appl. Phys. 47, 5248 (1976)].
Multilayer Dielectric Elastomers for Fast, Programmable Actuation without Prestretch (2016)

A novel method for the fabrication of dielectric elastomer actuators (DEAs) combines acrylic polymers and single wall carbon nanotube network electrodes. DEAs made using this technique do not require prestretching, have extremely thin electrodes, and can be actuated at low voltage. The method is applied to create a multimorph device with nine actuation modes based on just four inputs.
Consistency of fat mass–fat-free mass relationship across ethnicity and sex groups (2010)

The model developed by Forbes (1987) of how body fat mass (FM) and fat-free mass (FFM) change during periods of weight loss or gain (Δ body weight (BW)) assumed that they change in relationship to a constant C = 10·4, where ΔFFM/ΔBW = 10·4/(10·4+FM). Forbes derived C based on aggregated, cross-sectional data from a small sample of women. The objective of the present study was to reanalyse the relationship described by Forbes and to explore whether this relationship is consistent across ethnicity and sex groups using cross-sectional data from a large sample of white and African-American men and women. Baseline data from white and African-American men and women aged 18-60 years, who participated in a clinical study at the Pennington Biomedical Research Center since 2001 and who underwent dual-energy X-ray absorptiometry scans, were available for analysis. To overcome differences in BMI distributions among the ethnicity-by-sex groups, a stratified random sample of participants was selected within each group such that numbers in each BMI category ( < 25, 25-29·9, 30-34·9, 35-39·9, 40+ kg/m2) were proportional to those within the group with the smallest sample size, yielding a sample of 1953 individuals. Linear regression models assessed the FM-FFM relationship across the four ethnicity-by-sex groups. The FM-FFM relationship varied little by ethnicity (P = 0·57) or by sex (P = 0·26). The constant describing the FM-FFM relationship was estimated to be 9·7 (95 % CI 9·0, 10·3). In conclusion, results from our large, biethnic sample of men and women found a FM-FFM relationship very close to that originally described by Forbes, absent of significant variability by ethnicity or sex.
Treatment and outcome of CPD-associated peritonitis. (2006)

CPD-associated peritonitis is a leading cause of morbidity and mortality for ESRD patients maintained on CPD therapy. The percentage of ESRD patients maintained on CPD therapy is declining. The reasons are unclear, but may be due to concerns about CPD-associated peritonitis. The incidence of CPD-associated peritonitis has decreased largely attributed to technical advances and the identification of risk factors including exit-site infection, colonization with Staphylococcus aureus and depression. The typical spectrum of organisms causing peritonitis include gram-positive organisms (67%), gram-negative organisms (28%), fungi (2.5%) or anaerobic organisms (2.5%). Culture-negative episodes do occur: up to 20% of the episodes of peritonitis in some series are culture-negative. The treatment of CPD associated peritonitis is rather standardized with current recommendations by the International Society of Peritoneal Dialysis universally adopted. Approximately 80% of the patients developing peritonitis will respond to antimicrobial therapy and remain on CPD therapy, while 10 to 15% of the patients require catheter removal and transfer to hemodialysis. Approximately 6% of the patients expire as a result of peritonitis. The outcome is different based on organism with gram-negative and fungal episodes having a worse outcome than gram-positive episodes. The development of CPD-associated peritonitis can be linked to traditional risk factors such as exit-site infection and poor technique. Bacterial biofilm has also been suggested as a cause of peritonitis. Our current antimicrobial protocols may not permit adequate dosing to penetrate the biofilm and be a reason for recurrent or repeat episodes of peritonitis. It is important that we improve our understanding of factors responsible for the development and outcome of CPD-associated peritonitis in order for this renal replacement therapy to remain a viable option for patients with ESRD.
Differentiation of a human monocytic cell line by 1,25-dihydroxyvitamin D3 (calcitriol): a morphologic, phenotypic, and functional analysis (1984)

Several recent studies have suggested a role for 1,25-dihydroxyvitamin D3 (calcitriol) in myeloid differentiation. We have examined the effects of calcitriol on the U937 monoblast cell line and found that calcitriol, at near physiologic concentrations, is a potent inhibitor of U937 growth. Moreover, calcitriol induces differentiation to a monocyte-macrophage phenotype marked by enhanced alpha-naphthyl esterase staining. Morphologic changes were attended by de novo induction of the myeloid specific antigen detected by the monoclonal antibody AML-2-23, as well as dramatic increases in Fc receptors for IgG. In addition, calcitriol induced U937 cells to perform phagocytosis and antibody-dependent cellular cytotoxicity. These results indicate the potential activity of calcitriol in myeloid differentiation and additionally suggest a role for calcitriol in monocyte-macrophage activation.
Six <i>Arabidopsis thaliana</i> homologues of the human respiratory burst oxidase (<i>gp91<sup>phox</sup></i>) (1998)

An NADPH oxidase analogous to that in mammalian phagocytes has been hypothesized to produce reactive oxygen species (ROS) in the plant defence response. A. thaliana contains at least six gp91phox homologues, designated AtrbohA-F (A. thaliana Respiratory Burst Oxidase Homologues), which map to different positions. Transcripts of three of these genes can be detected in healthy plants by RNA gel blot analyses. The Atrboh gene products are closely related to gp91phox and the intron locations suggest a common evolutionary origin. A putative EF-hand Ca(2+)-binding motif in the extended N-terminal region of the Atrboh proteins suggests a direct regulatory effect of Ca2+ on the activity of the NADPH oxidase in plants.
Nonlinear electrokinetic ejection and entrainment due to polarization at nearly insulated wedges (2002)

We examine a singular electrokinetic flow around a corner or a wedge in micro-channels constructed from dielectric materials whose permittivity is small but finite compared to that of the electrolyte. When the wedge angle is less than 180°, the applied electric field, which is tangential far from the corner, develops a normal surface component that becomes singular at the corner. This normal field leakage causes opposite polarization at the two sides of the wedge and produces a converging singular tangential electrokinetic flow that ejects liquid from the tip. By expanding in cylindrical harmonics, we estimate this ejecting flow as a function of the permittivity ratio, applied electric field, angle of the wedge and the microscopic corner curvature that suppresses the singularity. The ejecting flow entrains tangential flow on the front side of the wedge and produces a vortex on the downstream side. This entrainment offers a long-range attractive hydrodynamic force that complements short-range electrostatic DLVO (Derjaguin–Landau–Verwey–Overbeek) and dielectrophoretic forces to enhance corner deposition and aggregation of colloids and proteins during electrophoresis/electro-osmosis.
Old formula, new Rx: The journey of PHY906 as cancer adjuvant therapy (2012)

Over a ten-year period, the multiplex technology "PhytomicsQC" has been used to show batch-to-batch consistency of PHY906 production. Advanced clinical trials are ongoing to demonstrate the effectiveness of PHY906 as adjuvant therapy for cancer patients undergoing chemotherapy.
Influence of Fatigue and Bending Strain on Critical Currents of Niobium Superconducting Flexible Cables Containing Ti and Cu Interfacial Layers (2016)

Niobium is a viable material for thin-film superconducting flexible microwave cables. To aid in the design of superconducting flexible cables using Nb, it is important to evaluate not only the superconductor electrical performance, but also mechanical reliability performance since these cables should be reasonably robust when flexed. In this paper, we performed fatigue and bending tests on Nb-only and Ti/Nb/Cu multilayer signal lines on flexible Kapton substrates and measured the change in critical current (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ) of these wires. From the fatigue tests, I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> , degradation of Nb-only cables occurred at a lower number of cycles than the Ti/Nb/Cu cables. After 250 fatigue cycles, Ti/Nb/Cu wires with the thickest Ti adhesion layer and Cu capping layer exhibited the lowest I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> degradation of ~1.2% and 0% in tensile and compressive cases, respectively. From bending tests, where the sample was held in an intentionally curved configuration during testing, I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> degradation of the Nb-only cables was more severe than that of the Ti/Nb/Cu cables during tensile bending and the I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> of Ti/Nb/Cu cables was minimally affected during compressive bending. These results demonstrate that a Ti adhesion layer and Cu capping layer provide reliability enhancement for superconducting Nb flex cables fabricated on Kapton.
Research on the real-time performance of power lithium battery assembly line based on CAN bus (2015)

Power lithium battery assembly production line adopts the distributed control system based on CAN bus, is divided into two levels, namely the station control layer( lower computer) and the production line management and control layer(IPC). Each station are connected to the CAN bus as a network node. In such multi-node and high load system, the standard CAN communication protocol can only ensure real-time transmission of high priority messages in the network, the real-time capability of low priority messages will reduce with the increase of the load, several competing failure will lead to uncertain delay of lower priority message transmission, even appear the phenomenon that the message is unable to send, cause packet loss and the station is jammed, resulting in the assembly is not normal. Based on this, this paper proposes a hybrid scheduling algorithm of the hierarchical structure, which combines the DMS algorithm and EDF algorithm in the index partitions, on the basis of the system real-time capability, not only make the system have higher bandwidth utilization, but also reduce the consumption of system resources.
Synthesis and Characterization of Water-Soluble and Bifunctional ZnO−Au Nanocomposites (2007)

The ability to synthesize multicomponent nanocomposites (NCs) is important for exploring their functional properties of not only individual single components but also their combinations in technological applications. This paper presents an investigation on the synthesis and characterization of water-soluble and bifunctional ZnO−Au NCs, of which ZnO provides fluorescence and Au is used for organic functionality for bioconjugation. ZnO nanocrystals were employed as seeding material for nucleation and growth of reduced gold by citrate to form the water-soluble ZnO−Au NCs. The morphology and components of the ZnO−Au NCs, characterized by the TEM and XRD, respectively, demonstrate a dumbbell-like shape and crystalline wurtzite ZnO together with face-center-cubic Au nanoparticles. The surface plasmon absorption band of ZnO−Au NCs in aqueous solution is distinctly broadened and red-shifted relative to monometallic Au nanoparticles, and the UV emission intensity is higher by about 1 order of magnitude in ZnO−Au NCs than in pure ZnO nanocrystals; these observations reflect the strong interfacial interaction between ZnO and Au. Moreover, multiphonon Raman scattering of ZnO is also largely enhanced by the strongly localized electromagnetic field of the Au surface plasmon.
Defining dishonesty: A culture clash of law and business Royal Brunei Airlines SDN BHD v Tan (1997)

Royal Brunei Airlines (the airline) had, in 1986, appointed Borneo Leisure Travel (BLT) as its agent for passenger and cargo transport sales in Sabah and Sarawak. Mr Tan was the founder of BLT, its managing director and its principal shareholder (the only other director and shareholder being his wife) and was, in effect, in sole control of BLT.
Simplified fluorometric assay of total selenium in plasma and urine (1990)

We describe here a single-tube assay that may be applied to the whole range of selenium status in adult and pediatric patients, including depletion during parenteral or other nutrition. A specimen or aqueous standard, 100 microL, is digested with 0.5 mL of HNO3/HCIO4 (4/1 by vol, at 190 degrees C for 90 min), reduced with 0.5 mL of concentrated HCI (150 degrees C, 30 min), and complexed with 0.5 mL of 6.3 mmol/L 2,3-diaminonaphthalene (DAN) reagent in the presence of EDTA (60 degrees C, 30 min). The resulting fluorophore is extracted into cyclohexane and its fluorescence measured (excitation at 366 nm; emission at 544 nm). It is not necessary to control pH during the complexing step or to protect the DAN from light. The limit of detection of selenium is 10 micrograms/L (0.126 mumol/L); linearity of results extends to 2000 micrograms/L (25.3 mumol/L). Between-batch precision is 5%, analytical recovery 90%-96%. Performance is good as tested against Reference Materials and by participation in a National Quality Assurance Scheme.
Far-Field Proppant Detection Using Electromagnetic Methods - Latest Field Results (2017)

Abstract Over 100 billion lbm of proppant are placed annually in wells across the globe, with the majority in unconventional reservoirs. The location of the proppant in these horizontal wells and formations is critical to understanding reservoir drainage, well spacing and stage spacing. However, for many years proppant detection has primarily been limited to near-wellbore measurements. A novel method to detect proppant in the far-field has been developed and is the subject of this paper. The method to detect proppant that has been developed utilizes electro-magnetic methods. This technology entails using a transmitter source and an array of electric- and magnetic-field sensors located at the surface. A current signal with a unique wave form and frequency is transmitted to the bottom of the wellbore via a standard electric line unit. In addition, an electrically conductive proppant is pumped into the stage(s) of interest. The electric- and magnetic-fields are measured both before and after the detectable proppant stages, and a novel analysis method is then employed to process and invert this differenced data to create an image of the propped reservoir volume. This technology is the product of years of development of computer models capable of forward modeling this technique. Once this modeling was completed, an initial field test was performed in west Texas, with a preliminary analysis of this work presented in a previous paper. Since that paper, however, additional processing of the data has yielded a much more detailed image of the proppant location in this Bone Springs well. In addition, a subsequent field application has been performed in a major basin in the Northeast US. Multiple stages received detectable proppant of varying stage volumes and the analysis has shown a detailed image of the proppant location in that wellbore also. In addition, the initial west Texas field test employed only electric-field sensors, while this latest test employed both electric- and magnetic-field receivers. Numerical simulations and field results indicate the percentage difference between pre- and post-frac results are two times higher using magnetic versus electric field sensors. This paper will review the technology development and methods, it will present the latest imaging from the initial west Texas test, and it will describe the latest learnings from the most recent field test. This paper should be beneficial to all completions and development personnel who are interested in knowing where proppant is located in their fractures. This technology has the potential to assist in understanding well drainage and spacing, stage and perf cluster spacing, vertical fracture coverage as well as the impact of fracture design changes.
Multiphase Adhesive Coacervates Inspired by the Sandcastle Worm (2011)

Water-borne, underwater adhesives were created by complex coacervation of synthetic copolyelectrolytes that mimic the proteins of the natural underwater adhesive of the sandcastle worm. To increase bond strengths, we created a second polymer network within cross-linked coacervate network by entrapping polyethylene glycol diacrylate (PEG-dA) monomers in the coacervate phase. Simultaneous polymerization of PEG-dA and cross-linking of the coacervate network resulted in maximum shear bond strengths of ∼1.2 MPa. Approximately 40% of the entrapped PEG-dA polymerized based on attenuated total reflectance-Fourier transform infrared spectroscopy. The monomer-filled coacervate had complex flow behavior, thickening at low shear rates and then thinning suddenly with a 16-fold drop in viscosity at shear rates near 6 s(-1). The microscale structure of the complex coacervates resembled a three-dimensional porous network of interconnected tubules. The sharp shear thinning behavior is conceptualized as a structural reorganization between the interspersed phases of the complex coacervate. The bond strength and complex fluid behavior of the monomer-filled coacervates have important implications for medical applications of the adhesives.
Targeted delivery of doxorubicin to breast cancer cells by aptamer functionalized DOTAP/DOPE liposomes (2015)

Doxorubicin is used to treat numerous types of tumors including breast cancer, yet dose-associated toxicities limit its clinical application. Here, we demonstrated a novel strategy by which to deliver doxorubicin to breast cancer cells by conjugating cancer cell-specific single-strand DNA aptamers with doxorubicin-encapsulated DOTAP:DOPE nanoparticles (NPs). We utilizing a whole-cell-SELEX strategy, and 4T1 cells with high invasive and metastatic potential were used as target cells, while non-invasive and non-metastatic 67NR cells were used as subtractive cells. Ten potential aptamers were generated after multi-pool selection. Studies on the selected aptamers revealed that SRZ1 had the highest and specific binding affinity to 4T1 cells. Then we developed SRZ1 aptamer-carried DOTAP:DOPE-DOX NPs. In vitro uptake results which were conducted by FACS indicated that the aptamer significantly promoted the uptake efficiency of DOTAP:DOPE-DOX NPs by 4T1 cells. ATPlite assay was performed to test 4T1, 67NR and NMuMG cell viability after treatment with free doxorubicin, DOTAP:DOPE-DOX particles and aptamer‑loaded DOTAP:DOPE-DOX particles. As expected, the aptamers effectively enhanced accumulation of doxorubicin in the 4T1 tumor tissues as determined by in vivo mouse body images and biodistribution analysis. Consistent with the in vitro findings, aptamer-conjugated doxorubicin-loaded DOTAP:DOPE particles markedly suppressed tumor growth and significantly increased the survival rate of 4T1 tumor-bearing mice. These studies demonstrated that aptamer SRZ1 could be a promising molecule for chemotherapeutic drug targeting deliver.
An Efficient and Mild Method for the Synthesis and Hydrazinolysis of <i>N</i>‐Glyoxylamino Acid Esters (2013)

N ‐Glyoxylamino acid ester derivatives were synthesized via the ring opening of N ‐acetylisatin using moderate conditions. During the hydrazinolysis of N ‐glyoxylamino acid ester derivatives with hydrazine hydrate (80%) in methanol, unexpected reduction of the α ‐keto group occurred to afford N ‐acylamino acid hydrazide derivatives in good yield (80–90%) (Wolff‐Kishner type reaction). All the synthesized compounds were characterized by 1 H NMR, 13 C NMR, and elemental microanalysis.