gebhart/patrepeval huggingface dataset:
Ice Management for Support of Arctic Floating Operations (2011)

Abstract As the industry moves further offshore in the Arctic where open water seasons are small to non-existent, ice management will be a critical enabling technology to allow floating vessels to keep station (for drilling, tanker loading, well workovers or subsea equipment maintenance). This paper describes some of the key considerations for accomplishing the complex task of ice management and demonstrates a simulation-based means for testing the efficacy of various tactics against measured ice data. Examples are provided wherein published ice management fleet deployment scenarios are evaluated using measured ice drift and thickness time histories provided by the Canadian Department of Fisheries and Oceans for prospective drilling sites in the Canadian Beaufort. The results provide insight into the ice management fleet composition, fleet deployment strategies and frequency/duration of expected downtime due to ice conditions that would exceed the operating limits of the fleet. Introduction A major challenge of high-Arctic development lies in water depths exceeding about 100 m, where the traditional bottom-founded structures become impractical and stationary floating vessels are required for drilling and other key offshore operations. Unmanaged drifting sea ice can generate loads far beyond the capabilities of conventional station-keeping systems that use either dynamic positioning (DP) or anchored moorings. Ice management -- the process of protecting a stationary vessel in moving ice using icebreakers working upstream of the vessel to create a continuous channel of thoroughly broken-up floes (Figure 1) -- is required to reduce ice loads to manageable levels. Contrary to traditional icebreaker operations, where escort icebreakers exploit weak zones in the ice to create a channel for a transiting vessel, ice management for a stationary vessel must deal with whatever ice drifts across the fixed location. Amongst the challenges is that sea ice frequently drifts at speeds over 1 knot, which can make it difficult for a reasonable number of icebreakers to process the ice into sufficiently small floe sizes. Additionally, the ice drift heading varies constantly, with frequent changes of 180 degrees or more in a few hours, which challenges the fleet's ability to maintain the protected vessel within the managed ice channel created by icebreakers working updrift in the moving ice. Finally, some multi-year ice floes in the high-Arctic are too thick to be broken by even the largest conceivable icebreakers, so it is important to know the frequency with which these features may be encountered.
Spatial and temporal information processing in the sea urchin embryo: modular and intramodular organization of the <i>CyIIIa</i> gene <i>cis</i>-regulatory system (1996)

The CyIIIa cytoskeletal actin gene of Strongylocentrotus purpuratus is expressed specifically in the aboral ectoderm. In earlier work we identified a 2.3 kb cis-regulatory region that is necessary and sufficient for correct spatial and temporal expression of a CyIIIa.CAT gene. This region includes about 20 sites of specific protein-DNA interaction, at which at least nine different transcription factors may be bound. All except two of these factors have been cloned. In this work we have analyzed by deletion or mutagenesis each specific interaction. A specific function was identified for every binding site examined. These individual functions include control of amplitude and timing of expression at different phases of embryogenesis, and control of spatial expression. We show that particular negative regulatory interactions are required to repress expression of the CyIIIa.CAT construct in oral ectoderm and in skeletogenic mesenchyme at different stages. In further experiments we determined the overall functional organization of the CyIIIa cis-regulatory system, and we show that this system is modular in its regulatory structure. The 'proximal module' (with respect to the transcription start site) extends upstream for about 800 base pairs, and includes nine target sites serviced by six different transcription factors. Its major role is to establish CyIIIa expression in the aboral ectoderm territory as the blastomere founder cells are specified and the oral-aboral axis is determined, and to activate the CyIIIa gene late in cleavage. The 'middle module,' which lies upstream of the proximal module, acquires major control of CyIIIa function after the blastula stage. It includes six target sites, serviced by four different factors. The middle module is responsible for a sharp increase in expression occurring during gastrulation, mediated by the positively acting factors that bind within it. The middle module also includes sites at which two different negatively acting spatial control factors bind, the functions of which are required for correct spatial expression late in embryogenesis. The 'distal module' contains a number of sites at which a positively acting factor binds, but this module exercises no spatial regulatory function. Interactions within the distal module are required for the normal levels of function of both the proximal and middle modules.
Evidence of Association of Salmonellae with Tomato Plants Grown Hydroponically in Inoculated Nutrient Solution (2002)

The possibility of uptake of salmonellae by roots of hydroponically grown tomato plants was investigated. Within 1 day of exposure of plant roots to Hoagland nutrient solution containing 4.46 to 4.65 log(10) CFU of salmonellae/ml, the sizes of the pathogen populations were 3.01 CFU/g of hypocotyls and cotyledons and 3.40 log(10) CFU/g of stems for plants with intact root systems (control) and 2.55 log(10) CFU/g of hypocotyls and cotyledons for plants from which portions of the roots had been removed. A population of > or =3.38 log(10) CFU/g of hypocotyls-cotyledons, stems, and leaves of plants grown for 9 days was detected regardless of the root condition. Additional studies need to be done to unequivocally demonstrate that salmonellae can exist as endophytes in tomato plants grown under conditions that simulate commonly used agronomic practices.
Irregular terms in the impulse response of a multiconductor lossy transmission line (1999)

Linear multiconductor transmission lines can be effectively represented in the time domain as a dynamic multiport through the describing input and transfer impulse responses. Unfortunately, these responses cannot be analytically evaluated for the most general case of lossy lines. In addition, they cannot even be evaluated numerically due to the presence of irregular terms such as Dirac pulses, functions that actually approximate Dirac pulses, and functions of the type 1//spl radic/t. Nevertheless, all these irregular terms can be isolated from the regular ones. This paper proposes an analytical method to evaluate exactly the irregular terms. This method is based on the perturbation theory of the spectrum of symmetric matrices and can be easily and effectively applied to the most general case of frequency-dependent lossy multiconductor lines. Once the irregular parts of the impulse responses are known, it is possible to evaluate accurately the regular ones through simple numerical methods, as shown through some examples.
Zero field NMR and NQR (1985)

Methods are described and demonstrated for detecting the coherent evolution of nuclear spin observables in zero magnetic field with the full sensitivity of high field NMR. The principle motivation is to provide a means of obtaining solid state spectra of the magnetic dipole and electric quadrupole interactions of disordered systems without the line broadening associated with random orientation with respect to the applied magnetic field. Comparison is made to previous frequency domain and high field methods. A general density operator formalism is given for the experiments where the evolution period is initiated by a sudden switching to zero field and is terminated by a sudden restoration of the field. Analytical expressions for the signals are given for a variety of simple dipolar and quadrupolar systems and numerical simulations are reported for up to six coupled spin-1/2 nuclei. Experimental results are reported or reviewed for 1H, 2D, 7Li, 13C, and 27Al nuclei in a variety of polycrystalline materials. The effects of molecular motion and bodily sample rotation are described. Various extensions of the method are discussed, including demagnetized initial conditions and correlation by two-dimensional Fourier transformation of zero field spectra with themselves or with high field spectra.
Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. (1992)

The retinoblastoma gene product (Rb), a nuclear phosphoprotein, functions as a tumor suppressor that is inactivated in retinoblastoma and other malignancies. The hypophosphorylated forms of Rb are observed in the G0/G1 phase of the cell cycle, whereas the hyperphosphorylated forms predominate in S and G2/M phases, suggesting that phosphorylation/dephosphorylation of Rb may regulate progression through the growth cycle. However, little is known about the intracellular signals that regulate phosphorylation/dephosphorylation of Rb. We show that D-erythro-sphingosine potently induces early dephosphorylation of Rb. Initial dephosphorylation was observed as early as 1 h after treatment of hematopoietic cells with sphingosine, whereas complete shift to the dephosphorylated form was seen 4 h after treatment. These effects occurred at concentrations of sphingosine as low as 100-500 nM, with maximal effects observed at 1-2.5 microM. These effects were specific to sphingosine, inasmuch as other lipids, amphiphiles, and long chain amino bases, as well as structural analogs of sphingosine, failed to induce dephosphorylation of Rb. Also, activation of second messenger systems including protein kinase C, cAMP-dependent kinases, and calcium ionophores, as well as inhibition of serine/threonine protein phosphatases, failed to induce dephosphorylation of Rb. Induction of Rb dephosphorylation by sphingosine preceded inhibition of growth and a specific arrest in the G0/G1 phase of the cell cycle. These studies, for the first time, identify an intracellular activator of Rb.
Water‐conducting properties of lipids during pollen hydration (2002)

Abstract Based on the authors’ previous work an attempt has been made to study water flow in the lipid matrix during pollen hydration. The present study has demonstrated that in the presence of small amounts of water, the type of lipids used defined the time of hydration of pollen in vivo on the stigma and in vitro . Several approaches were used including cryo‐scanning electron microscopy, magnetic resonance imaging and Fourier transform infrared microspectroscopic imaging, with the purpose of detecting very small amounts of water. The results show that no water is detectable in the lipid matrix. It was observed and concluded that the water for pollen hydration accumulates as a thin layer at the contact side between pollen and stigma, during the normal process of pollination in plant species with a wet stigma. However, using the same species deprived of the stigma by cell ablation, it was shown that the layer of water observed in wild‐type plants is not necessary for pollen hydration.
Screening for Drugs of Abuse with the Roche ONTRAK Assays (1992)

A family of manual, qualitative, latex agglutination inhibition immunoassay screening tests (ONTRAK, Roche) for amphetamines, barbiturates, cocaine, marijuana, morphine, and phencyclidine were evaluated. The assays are inexpensive, rapid, portable, and easy to perform, requiring little training to obtain proficiency. The tests are sensitive to drug concentrations at or around the stated cutoff values. The ONTRAK results agree well with the results obtained from fluorescence polarization immunoassay (FPIA) or radioimmunoassay (RIA) screening and GC/MS confirmation. Potential drawbacks of the test kits include the subjective nature of the qualitative assays and the lack of a positive control. The ONTRAK system provides a reasonable means of conducting field testing for drugs of abuse.
Question-Negotiation and Information Seeking in Libraries (1968)

Seekers of information in libraries either go through a librarian intermediary or they help themselves. When they go through librarians they must develop their questions through four levels of need, referred to here as the visceral, conscious, formalized, and needs. In his pre-search interview with an information-seeker the reference librarian attempts to help him arrive at an understanding of his compromised need by determining: (1) the subject of his interest; (2) his motivation; (3) his personal characteristics; (4) the relationship of the inquiry to file organization; and (5) anticipated answers. The author contends that research is needed into the techniques of conducting this negotiation between the user and the reference librarian.
Performance Evaluation of the Fiber-Reinforced Cement Composites Blended with Wheat Straw Ash (2019)

Increasing demand for cement in the construction industry is posing a serious threat to the environment. This necessitates the utilization of supplementary cementitious materials such as silica fume, fly ash, rice husk ash, and wheat straw ash as a cement replacement material. Additionally, fiber-reinforced cement composites can be efficiently used in repair and rehabilitation works. In this study, we have investigated the performance of fiber-reinforced cement composites blended with wheat straw ash. Wheat straw ash has been proved to be an effective pozzolanic material. Cement was replaced by 20% (weight) wheat straw ash. Polypropylene fibers were added at a dosage of 0%, 0.5%, 1%, and 2% by weight of cement. Mortar specimens were fabricated and investigated for the compressive, flexure, and indirect tensile strengths, ultrasonic pulse velocity, chloride migration resistance, and carbonation resistance. The results demonstrate that the addition of fibers caused a reduction in the compressive strength, pulse velocity, chloride migration resistance, and carbonation resistance; however, flexure and indirect tensile strengths were significantly enhanced. Moreover, the incorporation of fine size wheat straw ash particles compensated the negative effect of fiber inclusion.
Malware Analysis and attribution using Genetic Information (2012)

As organizations become ever more dependent on networked operations, they are increasingly vulnerable to attack by a variety of attackers, including criminals, terrorists and nation states using cyber attacks. New malware attacks, including viruses, Trojans, and worms, are constantly and rapidly emerging threats. However, attackers often reuse code and techniques from previous attacks. Both by recognizing the reused elements from previous attacks and by detecting patterns in the types of modification and reuse observed, we can more rapidly develop defenses, make hypotheses about the source of the malware, and predict and prepare to defend against future attacks. We achieve these objectives in Malware Analysis and Attribution using Genetic Information (MAAGI) by adapting and extending concepts from biology and linguistics. First, analyzing the “genetics” of malware (i.e., reverse engineered representations of the original program) provides critical information about the program that is not available by looking only at the executable program. Second, the evolutionary process of malware (i.e., the transformation from one species of malware to another) can provide insights into the ancestry of malware, characteristics of the attacker, and where future attacks might come from and what they might look like. Third, functional linguistics is the study of the intent behind communicative acts; its application to malware characterization can support the study of the intent behind malware behaviors. To this point in the program, we developed a system that uses a range of reverse engineering techniques, including static, dynamic, behavioral, and functional analysis that clusters malware into families. We are also able to determine the malware lineage in some situations. Using behavioral and functional analysis, we are also able to identify a number of functions and purposes of malware.
Polymeric calixarenes. Synthesis, polymerisation and Na+ complexation of a calix[4]arene methacrylate (1991)

S. J. Harris, G. Barrett and M. A. McKervey, J. Chem. Soc., Chem. Commun., 1991, 1224 DOI: 10.1039/C39910001224
Coupling losses in hollow waveguide laser resonators (1972)

Hollow waveguide gas lasers of the type described by Smith have some inherent loss in coupling radiation from the guide into free space and back into the guide. This paper calculates that loss for the EH <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</inf> lowest order waveguide mode as a function of mirror position and mirror radius. It is shown that some mirror positions and radii are optimum, in that they provide low coupling loss and are relatively insensitive to mirror position.
Type VI Microfilaments Interact with a Specific Region of Banded Collagen Fibrils in Skin (1998)

Immunolocalization studies demonstrate that Type VI collagen forms a flexible network that interweaves among collagen fibrils in the dermis of skin as well as in other loose connective tissues. Although binding of Type VI collagen with other matrix components has been suggested, no structural evidence supporting these studies has been reported. In this study, we demonstrate that Type VI microfilaments consistently crossbanded collagen fibrils near the "d" band, indicating that the interaction of Type VI collagen with banded fibrils is not passive. This "d" band is also the location of the binding domain of decorin to banded fibrils, suggesting that decorin mediates the interaction of Type VI microfilaments with banded fibers. Examination of the architecture of the Type VI network in a decorin nullizygous mouse demonstrates a continuance of this specific interaction, indicating that the association is not entirely dependent on the presence of decorin. At least one other component, whose identity is uncertain, persists near the "d" band, which may also serve to mediate the attachment of Type VI collagen to collagen fibrils.
DNA/Ligand/Ion-Based Ensemble for Fluorescence Turn on Detection of Cysteine and Histidine with Tunable Dynamic Range (2010)

A new type of rapid, highly sensitive, and selective fluorescence turn-on assay for detection of cysteine and histidine using a DNA/ligand/ion ensemble is developed. This assay is based on the highly specific interaction between the amino acids and the metal ions and the strong fluorescence thiazole orange (TO)/DNA probe in a competition assay format. The resulting high sensitivity and selectivity for cysteine and histidine was achieved by changing the metal ions. The system is simple in design and fast in operation and is more convenient and promising than other methods. The novel strategy eliminated the need of organic cosolvents, enzymatic reactions, separation processes, chemical modifications, and sophisticated instrumentations. The detection and discrimination process can be seen with the naked eye under a hand-held UV lamp and can be easily adapted to automated high-throughput screening. The detection limit of this method is lower than or at least comparable to previous fluorescence-based methods. The dynamic range of the sensor can be tuned simply by adjusting the concentration of metal ions. Importantly, the protocol offers high selectivity for the determination of cysteine among amino acids found in proteins and in serum samples. The assay shows great potential for practical application as a disease-associated biomarker and will be needed to satisfy the great demand of amino acid determination in fields such as food processing, biochemistry, pharmaceuticals, and clinical analysis.
A 4-10bit, 0.4-1V Power Supply, Power Scalable Asynchronous SAR-ADC in 40nm-CMOS with Wide Supply Voltage Range SAR Controller (2013)

This paper presents a wide range in supply voltage, resolution, and sampling rate asynchronous successive approximation register (SAR) analog-to-digital converter (ADC). The proposed differential flip-flop in SAR logic and high efficiency wide range delay element extend the flexibility of speed and resolution tradeoff. The ADC fabricated in 40nm CMOS process covers 4-10bit resolution and 0.4-1V power supply range. The ADC achieved 49.8dB SNDR and the peak FoM of 3.4fJ/conv. with 160kS/sec at 0.4V single power supply voltage. At 10bit mode and 1V operation, up to 10MS/s, the FoM is below 10fJ/conv. while keeping ENOB of 8.7bit.
Examining Population Stratification via Individual Ancestry Estimates versus Self-Reported Race (2005)

Population stratification has the potential to affect the results of genetic marker studies. Estimating individual ancestry provides a continuous measure to assess population structure in case-control studies of complex disease, instead of using self-reported racial groups. We estimate individual ancestry using the Federal Bureau of Investigation CODIS Core short tandem repeat set of 13 loci using two different analysis methods in a case-control study of early-onset lung cancer. Individual ancestry proportions were estimated for "European" and "West African" groups using published allele frequencies. The majority of Caucasian, non-Hispanics had >50% European ancestry, whereas the majority of African Americans had <20% European ancestry, regardless of ancestry estimation method, although significant overlap by self-reported race and ancestry also existed. When we further investigated the effect of ancestry and self-reported race on the frequency of a lung cancer risk genotype, we found that the frequency of the GSTM1 null genotype varies by individual European ancestry and case-control status within self-reported race (particularly for African Americans). Genetic risk models showed that adjusting for individual European ancestry provided a better fit to the data compared with the model with no group adjustment or adjustment for self-reported race. This study suggests that significant population substructure differences exist that self-reported race alone does not capture and that individual ancestry may be confounded with disease status and/or a candidate gene risk genotype.
Measurements of the Vertical Coherence Length in Neutron Interferometry (2008)

The study and use of macroscopic quantum coherence requires long coherence lengths. Here we describe an approach to measuring the vertical coherence length in neutron interferometry, along with improvements to the NIST interferometer that led to a measured coherence length of 790 A. The measurement is based on introducing a path separation and measuring the loss in contrast as this separation is increased. The measured coherence length is consistent with the momentum distribution of the neutron beam. Finally, we demonstrate that the loss in contrast with beam displacement in one leg of the interferometer can be recovered by introducing a corresponding displacement in the second leg.
Resolving the Grain Boundary and Lattice Impedance of Hot‐Pressed Li<sub>7</sub>La<sub>3</sub>Zr<sub>2</sub>O<sub>12</sub> Garnet Electrolytes (2013)

Rock solid: The cubic-stabilized garnet solid electrolyte with a nominal composition of Li6.28Al0.24La3Zr2O12 is thoroughly characterized by impedance spectroscopy. By varying the frequency of the applied AC signal over 11 orders of magnitude for characterizations from −100 to +60 °C, the relative contributions of grain and grain boundary conduction are unambiguously resolved.