gebhart/patrepeval huggingface dataset:
Dynamic Ad Insertion in Triple-Play Content Delivery Networks (CDNs) (2011)

The tremendous growth of digital content has brought about the need for monetization. Consolidated triple play infrastructure is needed to deliver Live, VOD, OTT and other range of media services. Further customization, personalization of content service for media content, ads etc is an important user experience consideration. In order to design robust advertising, a survey & investigation has been done on various ad technologies with respect to demographics & technology trends. It highlights strengths & weaknesses of existing methodologies. Based on these, In-stream ad technology approach is proposed for enabling dynamic ad-insertion in media streams. The research work focuses on understanding concept of BIFS, how using SMIL, dynamic ads can be inserted to deliver highly contextual user experience. It also highlights SMIL feature richness, along with XForms and ECMAScript, its acceptance and integration with CDN.
Herpes Simplex Virus as a Source of Thymidine Kinase for Thymidine Kinase-Deficient Mouse Cells: Suppression and Reactivation of the Viral Enzyme (1973)

Thymidine kinase (EC 2.7.1.21)-deficient mouse cells were infected with inactivated herpes simplex virus, after which "transformed" cells that produce viral thymidine kinase were isolated. Shortly after transformation, the expression of the viral enzyme could be suppressed and reactivated with high efficiency. On continued multiplication in nonselective medium, the proportion of cells producing the viral enzyme decayed exponentially. This decay seemed to represent a change in the expression of the viral gene for thymidine kinase rather than the loss of the gene from the cells, since the viral enzyme could be apparently reactivated in every cell, albeit at a very low frequency.
Predictions of Free-Carrier Electroabsorption and Electrorefraction in Germanium (2015)

Germanium is becoming an important material for mid-infrared photonics, but the modulation mechanisms in Ge are not yet well understood. In this paper, we estimate the size of free-carrier electroabsorption and electrorefraction effects in germanium across the 2 to 16-μm wavelength range at 300 K. The predictions are based as much as possible upon experimental absorption data from the literature and are supported by extrapolations from experimental data using first-principle quantum theoretical modeling. We find that free-carrier absorption is substantially stronger in Ge than in Si.
A wave-based anisotropic quadrangulation method (2010)

This paper proposes a new method for remeshing a surface into anisotropically sized quads. The basic idea is to construct a special standing wave on the surface to generate the global quadrilateral structure. This wave based quadrangulation method is capable of controlling the quad size in two directions and precisely aligning the quads with feature lines. Similar to the previous methods, we augment the input surface with a vector field to guide the quad orientation. The anisotropic size control is achieved by using two size fields on the surface. In order to reduce singularity points, the size fields are optimized by a new curl minimization method. The experimental results show that the proposed method can successfully handle various quadrangulation requirements and complex shapes, which is difficult for the existing state-of-the-art methods.
X-Ray Crystal Collimators Using Successive Asymmetric Diffractions and Their Applications to Measurements of Diffraction Curves. I. General Considerations on Collimators (1970)

General considerations are given on the intensity distributions obtained from various types of the collimator system made of a monolithic crystal, in which asymmetric Bragg-case diffractions take place successively by crystal components, so that an exploring beam of an extremely narrow angular spread of a few hundredths of the range of total reflection for the symmetric-case diffraction can be obtained. Type I and II of collimators use highly asymmetric diffractions; in type II the neighbouring components are inclined to each other to avoid deviation of the angular ranges of total reflection for two components. In type III the components are purposely arranged so that the angular ranges of total reflections for the neighbouring components overlap only partially. It is shown by calculations that an angular spread of about 0.1'' is obtained by collimators of the above types using 422 diffraction of silicon with CuKα.
Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities (2015)

Phenanthroindolizidine and phenanthroquinolizidine derivatives constitute a series of compounds that are being intensively studied as potential anticancer agents. Related natural products such as antofine and tylophorine alkaloids are well known for their high cytotoxic activity; however, their clinical application has been limited because of their side effects. In this review we report, in detail, on the main structural modifications applied to the phenanthroindolizidine and phenanthroquinolizidine skeletons, and we also describe their associated anticancer activities. New derivatives with promising antitumoral activities have emerged. Simplified analogues were prepared using rapid synthetic routes, and a certain number of these analogues displayed increased anticancer activity and selectivity towards tumor cell lines. It is hoped that a better understanding of the mechanisms of action associated with structure-activity relationships (SAR) will enable us to rationalize the development of new anticancer drugs.
Ethylene removal by sorption from polymeric crystalline frameworks (2008)

The uptake and diffusivity of ethylene in amorphous and semicrystalline s-PS (syndiotactic polystyrene) films presenting different crystalline phases and different crystalline-phase orientations have been studied by gravimetric and Fourier transform infrared measurements. High solubility and low diffusivity of ethylene have been observed for the nanoporous host δ phase of s-PS, due to the formation of a co-crystalline phase, where ethylene molecules are oriented nearly perpendicular to the polymer helices. In addition, ethylene diffusivity can be minimized by suitable (002) uniplanar orientation of the host crystalline phase, i.e. by placing the crystalline polymer helices perpendicular to the film surface. Ethylene-desorption measurements conducted at different temperatures have allowed us to evaluate activation energies relative to ethylene diffusion. The reported results suggest that this cheap, robust and easy-to-process polymeric material is suitable for (also for repeated use) food packaging requiring ethylene removal.
Color Video Picture Printer (1982)

Recently, new techniques of electronic photography which do not require any silver-based film have been explored. To expand the applications of electronic photography, a new printing system was envisioned to obtain hard copies of pictures normally only viewed on a TV screen. Development of a practical, hard copy printer can expedite the rapid growth of electronic photography and its applications.
Induction plasma torches (1971)

The design principles and construction are first presented and the important problem of plasma stability and the methods of maintaining stability, over a range of conditions and in different gases, are then considered. The power supplies and the various methods that have been used to initiate the torches are described. The various measurements that have been made of the gas heating efficiency are summarized showing that with the latest torches up to 70% of the input power can be coupled to the plasma even in the highest power units ( approximately 1 MW) developed. The measurements of the temperature distributions that have been reported are also presented showing that off-axis peak temperatures occur as a result of rf heating being confined to a certain skin depth. The theoretical attempts that have been made to describe the plasma behaviour are presented. The numerous applications of induction plasma torches are described under four headings: use a spectroscopic source the spheroidation of refractory materials, the growth of crystals and the production of chemicals
Carcinogenicity of dapsone in mice and rats (1980)

Dapsone (4,4'-diamino-diphenyl sulfone) has been tested for possible carcinogenicity in long-term animal experiments. BDIV rats and C₇ Bl mice received a 3.5% aqueous suspension of dapsone by intragastric intubation. Treatment was started in pregnant females during the last part of pregnancy, continued during lactation, then given to the offspring after weaning, five times a week for 104 weeks. The dose administered was 100 mg/kg to both rats and mice; total doses ranged from 10-16 g per rat and 1.2-1.4 g per mouse. Separate groups of animals received a combined treatment of dapsone with urethane or benzo (alpha) pyrene, to investigate the possible additive or synergistic action of dapsone with known carcinogens, as well as the possible inhibiting effect of dapsone on carcinogenesis. Unusual tumors, viz. spleen sarcomas (related to severe fibrosis of the spleen) were detected in male rats, and higher morbidity from C-cell thyroid carcinomas was observed in treated rats of both sexes than in control rats. There was no evidence that dapsone can modify the action of other chemical carcinogens. It was noted that: (1) although the increase in the incidence of tumours in dapsone-treated animals over that observed in untreated controls is statistically significant, the increase is relatively low; (2) the tumours appeared after lifetime treatment with maximum tolerated doses; (3) in rats, spleen sarcomas were observed mostly in males; this may indicate a possible hormone-dependence of the observed carcinogenic effect. The present results therefore provide only limited evidence of carcinogenicity of dapsone in rats.
Production of human immunodeficiency virus by chronically infected cells grown in protein‐free medium. (1995)

A human T cell line chronically infected with Human Immunodeficiency Virus (HIV) has been adapted to grow in a chemically defined, protein-free medium. Virus particles are produced at rates comparable to those of serum-supplemented cultures; virus preparations free of undesirable proteins can be produced in preparative amounts by simple ultrafiltration procedures and cell culture supernatants can be used as such for the preparation of ELISA solid phases. This material has been used very conveniently for studies concerning characterization of antibodies against HIV-specific proteins, interaction of HIV with complement components and inclusion of human cell-derived proteins into virions; we propose its use as a powerful tool for the structural as well as functional analysis of the virus particle itself.
Magnetic Materials for Digital Computer Components. II. Magnetic Characteristics of Ultra-Thin Molybdenum-Permalloy Cores (1955)

Measurements of the flux-reversal time τ as a function of the applied magnetic field H have been made for ⅛-mil, ¼-mil, ½-mil, and 1-mil 4–79 molybdenum-Permalloy tape cores. There measurements have been taken at seven temperatures, ranging from −196°C to 270°C. From these measurements, the switching coefficient Sw=(H−H0)τ is found, where H0 is the threshold field value for irreversible domain-wall motion. Determination of the switching coefficient as the tape thickness is varied permits a separation of the spin-relaxation and eddy-current contributions to switching delay. These contributions are studied individually as functions of temperature. Upon increasing the temperature over the range considered, the eddy-current contribution and the threshold field value H0 are approximately halved, and the spin-relaxation contribution is reduced by 20 percent. All these factors lead to a faster flux reversal at higher temperature for a given applied field. This behavior is in agreement with theoretical predictions.
A microfluidic platform towards automated multiplexed in situ sequencing (2019)

Advancements in multiplexed in situ RNA profiling techniques have given unprecedented insight into spatial organization of tissues by enabling single-molecule quantification and sub-micron localization of dozens to thousands of RNA species simultaneously in cells and entire tissue sections. However, the lack of automation of the associated complex experimental procedures represents a potential hurdle towards their routine use in laboratories. Here, we demonstrate an approach towards automated generation and sequencing of barcoded mRNA amplicons in situ, directly in fixed cells. This is achieved through adaptation of a microfluidic tool compatible with standard microscope slides and cover glasses. The adapted tool combines a programmable reagent delivery system with temperature controller and flow cell to perform established in situ sequencing protocols, comprising hybridization and ligation of gene-specific padlock probes, rolling circle amplification of the probes yielding barcoded amplicons and identification of amplicons through barcode sequencing. By adapting assay parameters (e.g. enzyme concentration and temperature), we achieve a near-identical performance in identifying mouse beta-actin transcripts, in comparison with the conventional manual protocol. The technically adapted assay features i) higher detection efficiency, ii) shorter protocol time, iii) lower consumption of oligonucleotide reagents but slightly more enzyme. Such an automated microfluidic tissue processor for in situ sequencing studies would greatly enhance its research potentials especially for cancer diagnostics, thus paving way to rapid and effective therapies.
Postoperative Pressure Therapy of Ear Keloids Using a Custom-Made Methyl Methacrylate Stent (2010)

The authors have indicated no significant interest with commercial supporters
PBIL PDR for scalable Bluetooth Indoor Localization (2009)

The ever-existing problems in indoor localization are attaining efficient scalability, reliability and accuracy besides cost efficiency. Although diverse approaches based on WLAN, Bluetooth, ZigBee, RFID and UWB had been divulged for localization and navigation, these schemes often do lack competent localization. Furthermore these schemes linger either expensive or be deficient in accuracy. Moreover not all technologies exist in smart phones. Recent outburst of technology expansion has paved way to solve indoor localization complexity by cohering various positioning methods and sensor models. In this paper, we developed a unified particle filter based localization approach based on Bluetooth positioning and pedestrian dead reckoning (PDR) method. We call this system as PBIL (PDR for scalable Bluetooth Indoor Localization). The proposed approach overcomes failure in the context of uninterrupted service where Bluetooth technologies lag behind. By coalescing Bluetooth and 3D compass sensor models, we surmount the localizing tribulations and guarantee a preeminent solution for pedestrian indoor localization and navigation.
Assessment of cell-mediated immunity against coxsackievirus B3-induced myocarditis in a primate model (Papio papio) (1981)

Delayed hypersensitivity and myocarditis were induced in five baboons (Papio papio) after inoculation with myocarditic murine coxsackievirus B3 (CVB3m). By means of the [3H]thymidine incorporation assay and the agarose droplet cell migration inhibition assay, specific cell-mediated immunity was detected in all five animals against viral antigens and/or KCl-extractable soluble antigens extracted from the heart of a CVB3m-inoculated baboon. KCl-extracted antigens from normal baboon heart tissues, as well as KCl-extracted antigens from spleen or liver tissues from a CVB3m-inoculated baboon, failed to stimulate baboon peripheral blood lymphocytes or inhibit the migration of baboon peritoneal exudate cells. The appearance of dissimilar antigen(s) in extracts of heart tissues from CVB3m-inoculated baboons which did not contain infectious CVB3m parallels the appearance of novel KCl-extractable antigen(s) induced by CVB3m in murine heart tissues (Paque et al., J. Immunol. 120:1672-1678). The animal model described represents the first systematic evaluation of cell-mediated immunity in CVB3m-induced myocarditis in primates and suggests that a similar phenomenon may occur in humans.
Convolutional Neural Network Based Structured Data Field Granularity Classification Method (2018)

The data warehouse provides data support for enterprise decision-making and online analysis. In the process of building a data warehouse, many heterogeneous source system data needs to be integrated. In the integration process, these heterogeneous data needs to be classified and put into different topics. The diversity of the source systems of large and medium-sized enterprises poses difficulties for granularity at the field-level automated classification. However, the accuracy of previous methods cannot satisfy users. Therefore, this paper proposes a neural network-based classification technology to classify the data in the granularity field. This method adopts a sampling method to construct the characteristics of the field and innovates a novel classification framework based on the database field on the basis of the CNN network. Accurately achieve 89% by testing the data in the TPC-DS's dimension tables, and achieve 93% accuracy in real-world data testing. This method was validated in the actual environment of the three banks in China and achieved satisfactory results.
Results of infrainguinal bypass for limb salvage in patients with end-stage renal disease. (1990)

Limb salvage in patients with end-stage renal disease (ESRD) is complicated by the diffuse, obstructive, calcific arteriopathy that makes anastomotic technique especially critical. Furthermore, decreased resistance to infection and impaired wound healing produced by host-factor deficiencies such as diabetes mellitus, hypoalbuminemia, uremia, and immunosuppression produce additional obstacles to successful limb salvage. This report summarizes our experience with distal arterial bypass procedures in these patients. A total of 32 bypass procedures were performed for limb salvage in 24 patients (17 diabetic) during a period of 5 years. The operative mortality rate was 6%. During the same period, 635 infrainguinal bypass procedures were performed by the in situ technique in patients without ESRD. Primary bypass patency was comparable in both groups at 24 months (92% vs 90%). In the group with ESRD, overall limb salvage was 83% at 2 years. Life-table analysis of bypass patency and limb salvage was thought not to be appropriate in the population with ESRD beyond 2 years because of the increased mortality rate (38%; 9/24) during this interval. It is important that limb salvage was achieved in diabetic patients with ESRD in the presence of extensive foot gangrene or ischemic ulceration. Revascularization should be considered strongly for limb salvage in all patients in this difficult population.
Segmentation of seismic data with complex stratigraphy using watershedding - preliminary results (2005)

The pressing need for computer assisted seismic interpretation tools leads us to suggest a new method for the segmentation of seismic data into regions of different internal configurations. The method, commonly known as watershedding, is used to segment the seismic data based on reflector spacing and continuity. Results on real seismic data show that the method is very powerful. Furthermore, the method is well suited to fuse different sources of a priori information.
A Phase 1 Study of CAL-101, An Isoform-Selective Inhibitor of Phosphatidylinositol 3-Kinase P110δ, In Combination with Rituximab and/or Bendamustine In Patients with Relapsed or Refractory B-Cell Malignancies. (2010)

Abstract Abstract 2832 Introduction: The class I phosphatidylinositol 3-kinases (PI3Ks) regulate a variety of cellular functions relevant to oncogenesis. Expression of the PI3K p110δ isoform (PI3Kδ) is restricted to cells of hematopoietic origin where it plays a key role in B cell proliferation and survival. CAL-101 is an isoform-selective inhibitor of PI3Kδ (EC50 of 8 nM in a cell-based assay with >200-fold selectivity relative to other PI3K isoforms). A Phase 1 study of single-agent CAL-101 demonstrated clinical activity in patients with indolent B-cell non-Hodgkin lymphoma (NHL), mantle cell lymphoma, and chronic lymphocytic leukemia (CLL); a favorable safety profile suggested that CAL-101 might successfully be combined with other agents active against lymphoid malignancies. Methods and Patients: This Phase 1 study was undertaken to evaluate the safety and activity of CAL-101 in combination with rituximab and/or bendamustine in patients with relapsed or refractory B-cell indolent NHL and CLL. All patients received CAL-101 100 mg orally twice per day (BID) in 28-day cycles for up to 12 cycles. Patients also received either rituximab 375 mg/m2 administered weekly for 8 weeks, starting on Day 1 of Cycle 1, or bendamustine 90 mg/m2 administered on Days 1 and 2 of each cycle for 6 cycles. Tumor response was evaluated according to standard criteria. Results: At data cutoff, 12 patients were enrolled in the study, including 6 with NHL and 6 with CLL. Patients included: males/females n=8 (67%)/4 (33%) with median age [range] of 65 [55-80] years, and relapsed/refractory disease n=8 (67%)/4 (33%). The median [range] number of prior therapies was 3 [1-11]. The number (%) of patients with specific prior therapies included: rituximab n=12 (100%), alkylating agent n= 10 (83%), purine analog n=9 (75%), and anthracycline/anthracenedione n=6 (50%). All patients received CAL-101 100 mg BID; 6 patients received rituximab and 6 received bendamustine. One patient with NHL had a dose reduction of bendamustine due to hiccups and 1 patient with NHL had a dose reduction of CAL-101 due to increased ALT/AST; all other patients received the full-dose regimen with acceptable tolerability. Preliminary clinical response assessments were available for 6 patients who had completed 2 cycles of combination treatment; the results are shown in the table. Enrollment is ongoing and dose escalation of CAL-101 is planned. Updated data will be presented at the meeting. Conclusions: Early results from this Phase 1 study of CAL-101, an oral PI3Kδ isoform-selective inhibitor, in combination with rituximab or bendamustine show acceptable safety and promising clinical activity in patients with relapsed or refractory indolent B-cell NHL and CLL. Disclosures: Flinn: calistoga: Research Funding. Off Label Use: CAL-101 for NHL. Leonard:Calistoga: Consultancy, Research Funding. Holes:Calistoga: Employment. Peterman:Calistoga: Employment. Yu:Calistoga: Employment.