gebhart/patrepeval huggingface dataset:
Measurement of the glycogen synthetic pathway in permeabilized cells of cyanobacteria (2001)

A simple, rapid and reliable procedure for permeabilizing cyanobacterial cells and measuring the glycogen synthetic pathway in situ, is presented. Cells from Anabaena sp. strain PCC 7120 were permeabilized with a mixture of toluene:ethanol (1:4 v/v). Fluorescence microscopy of cells incubated with fluorescein diacetate showed Anabaena non-permeabilized cells as green fluorescents, whereas permeabilized (viable) cells exhibited the intrinsic red fluorescence. Labelled alpha-1,4-glucan was recovered when permeabilized cells were incubated with the substrates of ADP-glucose pyrophosphorylase or glycogen synthase. The kinetic and regulatory properties of both enzymes could be reproduced in situ. The simplicity of the procedure and the ability to measure in situ glucan fluxes show the methodology as useful for studying the intracellular regulation of storage polysaccharides in a photosynthetic prokaryote.
Cytokine expression in a rat model of Staphylococcus aureus endophthalmitis. (1998)

S. aureus induced the expression of TNF-alpha, IL-1beta, CINC, and IFN-gamma. The time course of these cytokine levels could account for the clinical inflammatory responses and the entry and decline of vitreous cells in this model of bacterial endophthalmitis.
Conversion of Complex Sialooligosaccharides into Polymeric Conjugates and their Anti-Influenza Virus Inhibitory Potency (2000)

ABSTRACT To investigate the specificity of various influenza virus strains we have prepared polyacrylic type conjugates of undecasaccharide (Neu5Acα2-6Galβ1-4GlcNAcβ1-2Manα1)2-3,6Manβ1-4GlcNAcβ1-4GlcNAc (YDS), and trisaccharides 6‵-sialyl-N-acetyllactosamine (6‵SLN), 6‵-sialyllactose (6‵SL), and 3‵-sialyllactose (3‵SL). Free oligosaccharides were transformed to glycosylamine-1-N-glycyl derivatives by sequential action of NH4HCO3, chloroacetic anhydride, and aqueous NH3. The known derivatization protocol has been optimized for these sialooligosaccharides. Coupling of obtained amino-spacered derivatives with poly(4-nitrophenyl acrylate) gave rise to two types of conjugates, namely with polyacrylic acid and polyacrylamide backbones; the conversion proceeded quantitatively and without destruction of the oligosaccharides. The content of oligosaccharides in the conjugates was 10, 20, and 30% mol for 3‵SL, 6‵SL, 6‵SLN, and 2, 5 and 10% mol for YDS. Free oligosaccharides and the glycoconjugates were tested as inhibitors of influenza virus adhesion, and also as blockers of virus infectivity in MDCK cell culture. Biantennary YDS demonstrated similar activity to trisaccharide 6‵SLN both as the free form and neoglycoconjugate.
Refugee women and economic self-reliance (1992)

This article examines the lessons to be derived from programmes implemented in refugee situations to help women attain greater economic self-reliance. It begins by setting the overall context for these programmes: the objective, not always realized, of moving from a relief orientation in refugee programmes towards a development approach. It then describes the various economic activities in which women engage in refugee settings. The article continues with a critique of one means of assisting women become economically self-reliant: income-generation projects for refugee women. The article then discusses the relationships that need to be established between relief and development organizations to promote greater self-reliance for refugee women, referring in particular to the working relationship being established between the UN High Commissioner for Refugees (UNHCR) and UNIFEM (United Nations Development Fund for Women). It concludes with recommendations for future efforts to enhance the self-reliance of refugee women.
Casework as friendship: A long‐term contact with a paranoid lady (1995)

Abstract Case Management has been part of the social work tradition for many years; this report of a creative, decade‐long intervention with an isolated, older woman explores the boundaries between friendship and professional activity.
CUB Domain–Containing Protein 1, a Prognostic Factor for Human Pancreatic Cancers, Promotes Cell Migration and Extracellular Matrix Degradation (2010)

CUB domain-containing protein 1 (CDCP1) is a membrane protein that is highly expressed in several solid cancers. We reported previously that CDCP1 regulates anoikis resistance as well as cancer cell migration and invasion, although the underlying mechanisms have not been elucidated. In this study, we found that expression of CDCP1 in pancreatic cancer tissue was significantly correlated with overall survival and that CDCP1 expression in pancreatic cancer cell lines was relatively high among solid tumor cell lines. Reduction of CDCP1 expression in these cells suppressed extracellular matrix (ECM) degradation by inhibiting matrix metalloproteinase-9 secretion. Using the Y734F mutant of CDCP1, which lacks the tyrosine phosphorylation site, we showed that CDCP1 regulates cell migration, invasion, and ECM degradation in a tyrosine phosphorylation-dependent manner and that these CDCP1-associated characteristics were inhibited by blocking the association of CDCP1 and protein kinase Cdelta (PKCdelta). CDCP1 modulates the enzymatic activity of PKCdelta through the tyrosine phosphorylation of PKCdelta by recruiting PKCdelta to Src family kinases. Cortactin, which was detected as a CDCP1-dependent binding partner of PKCdelta, played a significant role in migration and invasion but not in ECM degradation of pancreatic cells. These results suggest that CDCP1 expression might play a crucial role in poor outcome of pancreatic cancer through promotion of invasion and metastasis and that molecules blocking the expression, phosphorylation, or the PKCdelta-binding site of CDCP1 are potential therapeutic candidates.
PTTG mRNA expression in primary breast cancer: a prognostic marker for lymph node invasion and tumor recurrence (2003)

The proto-oncogene pituitary tumor-transforming gene (PTTG) is described as abundantly overexpressed in a variety of neoplasms and cancer cell lines. We analyzed PTTG mRNA expression in 72 tumor samples derived from primary tumors of patients suffering from breast cancer and in unaffected breast epithelium, checking for correlations between expression levels and standard clinico-pathological parameters over a 5-year observation period. We found a direct correlation between PTTG mRNA overexpression and lymph node infiltration. Furthermore, overexpression of this gene in tumors correlated with a higher degree of tumor recurrence within the subsequent observation period. Taken together, these results demonstrate that determination of PTTG expression in primary tumors of the breast is a powerful tool for the assessment of potential tumor aggressiveness.
Narrative Visualization: Telling Stories with Data (2010)

Data visualization is regularly promoted for its ability to reveal stories within data, yet these “data stories” differ in important ways from traditional forms of storytelling. Storytellers, especially online journalists, have increasingly been integrating visualizations into their narratives, in some cases allowing the visualization to function in place of a written story. In this paper, we systematically review the design space of this emerging class of visualizations. Drawing on case studies from news media to visualization research, we identify distinct genres of narrative visualization. We characterize these design differences, together with interactivity and messaging, in terms of the balance between the narrative flow intended by the author (imposed by graphical elements and the interface) and story discovery on the part of the reader (often through interactive exploration). Our framework suggests design strategies for narrative visualization, including promising under-explored approaches to journalistic storytelling and educational media.
East-Country' in the ' O.E.D.' (1956)

Journal Article East-Country' in the ' O.E.D.' Get access George Herman George Herman 1University of Kansas Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 3, Issue 1, 1 January 1956, Pages 38–41, https://doi.org/10.1093/nq/3.1.38a Published: 01 January 1956
Increased dietary long-chain polyunsaturated fatty acids alter serum fatty acid concentrations and lower risk of urine stone formation in cats (2017)

The lifespan of cats with non-obstructive kidney stones is shortened compared with healthy cats indicating a need to reduce stone formation and minimize chronic kidney disease. The purpose of this study was to investigate the effects of increasing dietary polyunsaturated fatty acids (PUFA) on urine characteristics. Domestic-short-hair cats (n = 12; mean age 5.6 years) were randomized into two groups and fed one of two dry-cat foods in a cross-over study design. For one week before study initiation, all cats consumed control food that contained 0.07% arachidonic acid (AA), but no eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Group 1 continued eating control food for 56 days. Group 2 was fed test food for 56 days, which was control food plus fish oil and high-AA oil. Test food contained 0.17% AA, 0.09% EPA and 0.18% DHA. After 56 days, cats were fed the opposite food for another 56 days. At baseline and after each feeding period, serum was analyzed for fatty acid concentrations, and urine for specific gravity, calcium concentration, relative-super-saturation for struvite crystals, and a calcium-oxalate-titrimetric test was performed. After consuming test food, cats had increased (all P<0.001) serum concentrations of EPA (173%), DHA (61%), and AA (35%); decreased urine specific gravity (P = 0.02); decreased urine calcium concentration (P = 0.06); decreased relative-super-saturation for struvite crystals (P = 0.03); and increased resistance to oxalate crystal formation (P = 0.06) compared with cats consuming control food. Oxalate crystal formation was correlated with serum calcium concentration (r = 0.41; P<0.01). These data show benefits for reducing urine stone formation in cats by increasing dietary PUFA.
The Prostanoid Receptors: Molecular Approaches to Drug Development. Inflammation-allergy and prostanoids. (1). Prostanoids in experimental inflammatory reaction. (2001)

It is known that prostaglandins (PGs) modify the inflammatory reaction in concert with other biologically active mediators. However, characteristics of these interactions or modulating actions have not yet been clarified well. Recently, the production of mice with specific receptor deficiencies by using the gene targeting procedure for PG receptors has accelerated elucidation of the roles of PGs through correlation of their phenotypes and experimental features. Here I discuss roles of PGs in experimental paw edema, the writhing reaction of a pain model, and regulation of cytokine production, as determined using some PG-receptor-deficient mice. From the experiment of carrageenin-induced paw edema in IP receptor-deficient mice, with an indomethacin or bradykinin antagonist, we conclude that bradykinin initially induces paw swelling and then stimulates the release PGI2, which in turn enhances the swelling with bradykinin. By comparing the writhing responses in IP-deficient and wild-type mice, we found that PGI2 is a main mediator for this pain reaction. However, in the LPS-pretreated mice, not only PGI2 but also other PGs produced by COX-2 may be involved in pain induction. Production of TNF alpha and IL-10 was modified with PGI2 or PGE2; the production of TNF alpha was down-regulated by the stimulation via IP-, EP2- or EP4 receptor, but that of IL-10 was up-regulated by these receptors, resulting in an anti-inflammatory effect.
Ann Lyne (1879)

Journal Article Ann Lyne Get access E. C. G. E. C. G. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s5-XII, Issue 292, 2 August 1879, Page 96, https://doi.org/10.1093/nq/s5-XII.292.96a Published: 02 August 1879
Rheological, Interfacial and Thermal Control of Polymer Adhesion. I. Isothermal Theoryf (1988)

Abstract We have developed an isothermal theory of separation in polymer-solid adhering systems. The model used is based on the (observed) drawing of filaments between a bulk polymer and a solid. In the isothermal theory, a criterion is set up, demarcating filament elongation vs. detachment of the filament base from the solid. It employs a dimensionless parameter, ω, that relates free energy of adhesion, elongational viscosity or yield strength of the polymer, and filament size, to adhesive performance. The isothermal theory can be applied directly to the separation processes that occur with pressure-sensitive adhesives. Certain observations by Aubrey and Sherriff, by Gardon and by Kaelble are explained. The validity of the demarcation is believed to extend beyond pressure-sensitive systems, to all thermoplastic adhesives and/or coatings. Key Words: Free energy of adhesionrheological control of separationviscosityelongational viscositydemarcation between interfacial and cohesive separationfilamentationpolymer adhesion.
Coverage planning for outdoor wireless LAN systems (2003)

Wireless LANs (WLANs) are becoming increasingly popular for providing high data rate network access to mobile computers. Most of the currently deployed systems operate in the 2.4 GHz unlicensed frequency band. However, increasing demand for higher data rates and network capacities has led to new system standards for the 5 GHz band. We examine methods for obtaining a close-to-optimal positioning of WLAN access points (APs) and evaluate their performance in a typical downtown or campus environment. The system performance is evaluated using an objective function which aims to maximize both the coverage area and the overall signal quality. The optimization algorithms evaluate this objective function over a discrete search space, thereby considerably reducing the inherent complexity of the problem, while at the same time providing a reasonable approximation to the continuous optimization problem. Numerical results show that random search algorithms, such as simulated annealing, can yield very good solutions. However, the convergence speed of simulated annealing strongly depends on the fine-tuning of simulation parameters and a good choice of the initial set of transmitter positions. Successive removal algorithms, such as pruning, though usually producing sub-optimal solutions, converge in polynomial time. We therefore propose a combination of the two approaches - using pruning for obtaining an initial set of transmitter positions and refining these by using either neighborhood search or simulated annealing.
Multivalent Dendritic Molecules as Broad Spectrum Bacteria Agglutination Agents (2013)

This study reports the first set of synthetic molecules that act as broad spectrum agglutination agents and thus are complementary to the specific targeting of antibodies. The molecules have dendritic architecture and contain multiple copies of zinc(II)-dipicolylamine (ZnDPA) units that have selective affinity for the bacterial cell envelope. A series of molecular structures were evaluated, with the number of appended ZnDPA units ranging from four to thirty-two. Agglutination assays showed that the multivalent probes rapidly cross-linked ten different strains of bacteria, regardless of Gram-type and cell morphology. Fluorescence microscopy studies using probes with four ZnDPA units indicated a high selectivity for bacteria agglutination in the presence of mammalian cells and no measurable effect on the health of the cells. The high bacterial selectivity was confirmed by conducting in vivo optical imaging studies of a mouse leg infection model. The results suggest that multivalent ZnDPA molecular probes with dendritic structures have great promise as selective, broad spectrum bacterial agglutination agents for infection imaging and theranostic applications.
An approach for automatic grid generation in three-dimensional FDTD simulations of complex geometries (2002)

The finite-different time-domain (FDTD) method has become a popular method in computational electromagnetics because of its simplicity, flexibility, and efficiency. However, the process of generating a three-dimensional (3D) FDTD grid can be time-consuming and error-prone when manually manipulating complex geometries. In order to expedite the generation of FDTD grids, computer-graphics-based methods can alternatively be used. Starting from the geometric description of the problem domain given by a CAD file, an FDTD grid with a specific spatial resolution can be automatically produced. A simple algorithm to this end is discussed, along with sample results.
Optical and Electrical Properties of Si Nanocrystals Embedded in SiO<sub>2</sub>Layers (2003)

Si nanocrystals were formed using a Pt nanoscale island etching mask. A high-resolution transmission electron microscopy image showed that the Si nanocrystals were created inside a SiO2 layer, and the cathodoluminescence spectrum showed that the luminescence peak is related to the Si nanocrystals. Capacitance-voltage measurements on Al/SiO2/nanocrystalline Si/SiO2/p-Si structures at 300 K showed that the value of the flatband voltage shift increased parabolically with increasing Si nanocrystal size. These results indicate that Si nanocrystals can be formed using a Pt island etching mask and that the magnitude of the flatband voltage shift for the Al/SiO2/nanocrystalline Si/SiO2/p-Si structures is significantly affected by the size of the Si nanocrystals embedded in the SiO2 layer.
Morphological Changes in Ultraviolet-Nanoimprinted Resin Patterns Caused by Ultraviolet-Curable Resins Absorbing Pentafluoropropane (2012)

In this article, we revealed the maximum values of pentafluoropropane (PFP) absorbed by acrylate-type monomers and UV-curable resins causing radical photopolymerization and measured the viscosities in a state saturated with PFP. We described the influences of PFP condensable gas effectively used in UV nanoimprinting on the morphologies of resin patterns fabricated by UV nanoimprinting. The weights of the resins and monomers were increased by exposure to a PFP atmosphere, while the viscosities were reduced markedly. The absorption of PFP depended on the chemical structures of the monomers. The solubility parameter calculated by the Hoy method clearly suggested that the monomer with a solubility parameter of 20 (J cm-3)1/2 absorbed the most PFP. The UV-curable resin composed of the monomer absorbing a large amount of PFP resulted in morphological changes in nanoimprinted resin patterns where the height was lowered and the outermost surface became rough. The UV-curable resins having hydroxyl groups play an important role in preserving the size fidelity of UV-nanoimprinted resin patterns.
A Cognitive Mental Algorithm based on Psychoanalysis Theory: Theoretical study for design the mental model of a next intelligent robot (2007)

This paper presents a theoretical study for making intelligent robots with human-like mind. For the development of a cognitive mental model, we developed three algorithms based on the cognitive process for human psychoanalysis. Specifically, the concept of id, ego and superego from the theory of Sigmund Freud was adopted and the procedural algorithms were presented.
Genre as social action (1984)

This essay proposes a conception of genre based on conventionalized social motives which are found in recurrent situation‐types. The thesis is that genre must be conceived in terms of rhetorical action rather than substance or form.
Vapor Pressures of Solid Hydrates of Nitric Acid: Implications for Polar Stratospheric Clouds (1993)

Thermodynamic data are presented for hydrates of nitric acid: HNO(3).H(2)O, HNO(3).2H(2)O, HNO(3).3H(2)O, and a higher hydrate. Laboratory data indicate that nucleation and persistence of metastable HNO(3).2H(2)O may be favored in polar stratospheric clouds over the slightly more stable HNO(3).3H(2)O. Atmospheric observations indicate that some polar stratospheric clouds may be composed of HNO(3).2H(2)O and HNO(3).3H(2)O. Vapor transfer from HNO(3).2H(2)O to HNO(3).3H(2)O could be a key step in the sedimentation of HNO(3), which plays an important role in the depletion of polar ozone.
Optimization of an organic memristor as an adaptive memory element (2009)

The combination of memory and signal handling characteristics of a memristor makes it a promising candidate for adaptive bioinspired information processing systems. This poses stringent requirements on the basic device, such as stability and reproducibility over a large number of training/learning cycles, and a large anisotropy in the fundamental control material parameter, in our case the electrical conductivity. In this work we report results on the improved performance of electrochemically controlled polymeric memristors, where optimization of a conducting polymer (polyaniline) in the active channel and better environmental control of fabrication methods led to a large increase both in the absolute values of the conductivity in the partially oxydized state of polyaniline and of the on-off conductivity ratio. These improvements are crucial for the application of the organic memristor to adaptive complex signal handling networks.
Improvement of the Probe for Measuring Water Flow Rate in Intact Plants with the Stem Heat Balance Method (1984)

A probe was improved for measuring the rate of water flow in the stem of intact plants with the stem heat balance method. It consists essentially of flexible flat heater for feeding constant heat energy to a plant stem, heat flow sensing element for determining heat loss from the surface of the heater to the surrounding air and thermocouples for detecting stem temperatures. The improved probe can be easily set and removed to/from the stem and hardly arrests the radial growth of the plant stem. The comparison of the transpiration rate measured by a balance and the water flow rate determined by the new probe showed that the new probe was able to determine the water flux in a thin plant stem with acceptable error which was almost the same level attained with the original measuring device.
Selection of Amino Acid Sequences in the Beta Chain of the T Cell Antigen Receptor (1988)

The induction of an immune response in mammals is initiated by specifically reactive T lymphocytes. The specificity of the reaction is mediated by a complex receptor, part of which is highly variable in sequence and analogous to immunoglobulin heavy- and light-chain variable domains. The functional specificity of the T cell antigen receptor is, however, markedly different from immunoglobulins in that it mediates cell-cell interactions via the simultaneous recognition of foreign antigens and major histocompatibility complex-encoded molecules expressed on the surface of various lymphoid and nonlymphoid cells. The relation between the structure of the receptor and its functional specificity was investigated by analyzing the primary sequences of the receptors expressed by a series of T lymphocyte clones specific for a model antigen, pigeon cytochrome c. Within this set of T lymphocyte clones there was a striking selection for amino acid sequences in the receptor beta-chain in the region analogous to the third complementarity-determining region of immunoglobulins. Thus, despite the functional differences between T cell antigen receptors and immunoglobulin molecules, analogous regions appear to be important in determining ligand specificity.
Speech Enhancement Based On Noise Adaptive Nonlinear Microphone Array (2015)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000