gebhart/patrepeval huggingface dataset:
Particulate inspection of parenteral products: an assessment. (1981)

The international drive to achieve higher quality and improved cost effectiveness in parenteral products has achieved an apparent concensus concerning the utility and desirability of automated particulate inspection systems. Any perspective on widespread inspection automation must commence with the establishment of realistic objective standards based on sound scientific principles. Economically acceptable methodology must also be available to achieve validation for new procedures and devices. Standards, techniques, and sampling schemes applicable to evaluation and validation of particulate inspections are discussed.
Bubble Transducer for Radiating High-Power Low-Frequency Sound in Water (1960)

The bubble transducer consists of a conventional low-impedance electrodynamic driver with an air-filled rubber membrane, or “bubble,” of adjustable volume over the diaphragm. The system at resonance produces large volume displacement of the water with small linear diaphragm displacement at frequencies below 200 cps. For constant diaphragm volume velocity, the addition of the resonating bubble increases the power output by a factor of approximately 1000.
Sensitivity and mitigation of Reverse IMD in power amplifiers (2011)

The generation of intermodulation distortion products due to the coupling of signals into the output port of an amplifier, often referred to as Reverse Intermodulation Distortion (IMD) can be a major problem when multiple transmitters are operated in close proximity. Such conditions can exist at cell telephone sites, broadcast facilities and even on satellites. This type of distortion can also be a problem when making high linearity measurements. The sensitivity of different types of power amplifiers to Reverse IMD and techniques for mitigating the resulting distortion has been experimentally investigated.
FOXO4 Is Acetylated upon Peroxide Stress and Deacetylated by the Longevity Protein hSir2 (2004)

FOXO transcription factors have important roles in metabolism, cellular proliferation, stress tolerance, and aging. FOXOs are negatively regulated by protein kinase B/c-Akt-mediated phosphorylation. Here we show that FOXO factors are also subject to regulation by reversible acetylation. We provide evidence that the acetyltransferase CREB-binding protein (CBP) binds FOXO resulting in acetylation of FOXO. This acetylation inhibits FOXO transcriptional activity. Binding of CBP and acetylation are induced after treatment of cells with peroxide stress. Deacetylation of FOXOs involves binding of the NAD-dependent deacetylase hSir2(SIRT1). Accordingly, hSir2(SIRT1)-mediated deacetylation precludes FOXO inhibition through acetylation and thereby prolongs FOXO-dependent transcription of stress-regulating genes. These data demonstrate that acetylation functions in a second pathway of negative control for FOXO factors and provides a novel mechanism whereby hSir2(SIRT1) can promote cellular survival and increase lifespan.
[Recent progress in 'HMGA1a' which causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease]. (2003)

The aberrant splicing isoform(PS2V), generated by exon 5 skipping of the Presenilin-2(PS2) gene transcript, is a diagnostic feature of sporadic Alzheimer's disease(sAD). We found PS2V is hypoxia-inducible in SK-N-SH cells and purified a responsible trans-acting factor based on its binding to an exon 5 fragment. The factor was identified as the High Mobility Group protein A1a: (HMGA1a). HMGA1a bound to a specific sequence on exon5, located upstream of the 5'-splice site. HMGA1a expression was induced by hypoxia. Over-expression of HMGA1a generated PS2V, through interference with U1snRNP binding to the 5'-splice site and caused exon5 skipping. HMGA1a levels were increased in brain from sAD patients. We propose a novel mechanism of sAD that involves HMGA1a-induced aberrant splicing of PS2 pre-mRNA in the absence of any mutations.
Arrays of individually controlled ions suitable for two-dimensional quantum simulations (2016)

A precisely controlled quantum system may reveal a fundamental understanding of another, less accessible system of interest. A universal quantum computer is currently out of reach, but an analogue quantum simulator that makes relevant observables, interactions and states of a quantum model accessible could permit insight into complex dynamics. Several platforms have been suggested and proof-of-principle experiments have been conducted. Here, we operate two-dimensional arrays of three trapped ions in individually controlled harmonic wells forming equilateral triangles with side lengths 40 and 80 μm. In our approach, which is scalable to arbitrary two-dimensional lattices, we demonstrate individual control of the electronic and motional degrees of freedom, preparation of a fiducial initial state with ion motion close to the ground state, as well as a tuning of couplings between ions within experimental sequences. Our work paves the way towards a quantum simulator of two-dimensional systems designed at will.
Identification of a Novel <i>Citrobacter rodentium</i> Type III Secreted Protein, EspI, and Roles of This and Other Secreted Proteins in Infection (2004)

Citrobacter rodentium is a member of a group of pathogens that colonize the lumen of the host gastrointestinal tract via attaching and effacing (A/E) lesion formation. C. rodentium, which causes transmissible colonic hyperplasia in mice, is used as an in vivo model system for the clinically significant A/E pathogens enterohemorrhagic and enteropathogenic Escherichia coli. These bacteria all contain a pathogenicity island called the locus of enterocyte effacement (LEE), which encodes a type III secretion system that is designed to deliver effector proteins into eukaryotic host cells. These effectors are involved in the subversion of host eukaryotic cell functions to the benefit of the bacterium. In this study we used mutant strains to determine the effects of the C. rodentium LEE-encoded effectors EspF, EspG, EspH, and Map on virulence in the mouse model. In addition, we identified a novel secreted protein, EspI encoded outside the LEE, whose secretion is also dependent on a functional type III secretion system. Mutant strains with each of the effectors investigated were found to be outcompeted by wild-type bacteria in mixed-infection experiments in vivo, although the effects of EspF and EspH were only subtle. In single-infection experiments, we found that EspF, EspG, and EspH are not required for efficient colonization of the mouse colon or for the production of hyperplasia. In contrast, strains producing EspI and Map had significant colonization defects and resulted in dramatically reduced levels of hyperplasia, and they exhibited very different growth dynamics in mice than the wild-type strain exhibited.
Inflammation and coronary artery disease (2018)

The worldwide prevalence of cardiovascular disease in general and atherosclerotic coronary artery disease in particular is a health and economic concern of unparalleled proportion. Despite a long history of astute observations beginning in 1575 made by Fallopius, followed by those of von Rokatansky, Virchow, Osler, and Ross, and incremental knowledge of the pathobiology of atherosclerosis to include varying stages of inflammation, response to internally and externally mediated vascular injury, and impaired homeostasis, gaps in the field's understanding persist. Here, we summarize the current scope of the problem for coronary artery disease, emerging constructs in its pathobiology and common clinical phenotypes, potentially useful biomarkers, clinical trials designed specifically to test the 'inflammation hypothesis' of disease, and the interface of pathobiology and precision medicine as a foundation for diagnosis, management, and future advances in the diagnosis, prognosis, natural history, prevention, and optimal management.
Semiconductor-laser self pulsing due to deep level traps (1978)

By adding a rate equation for the charge state of deep-level traps to the rate equations for electron and photon density, it is shown that the observed self pulsing observed in semiconductor lasers can be due to the presence of deep-level traps with less than 1017 cm−3 density.
Introduction of Al into the HPM-1 Framework by In Situ Generated Seeds as an Alternative Methodology (2018)

An alternative method for the introduction of aluminum into the STW zeolitic framework is presented. HPM-1, a chiral STW zeolite with helical pores, was synthesized in the pure silica form, and an aluminum source was added by in situ generated seeds. Displacements of the peak positions in the Al samples were found in the X-ray diffractograms, indicating the possible incorporation of the heteroatom into the framework. Using an analysis of the 29Si and 27Al magic-angle spinning nuclear magnetic resonance (MAS NMR) spectra, we concluded that the aluminum was effectively introduced into the framework. The (AlTETRAHEDRAL/AlOCTAHEDRAL) ratio and its textural properties were studied to explain the catalytic ethanol conversion results at medium temperatures. The sample with the lowest Si/Al ratio showed the best results due to its higher surface area and pore volume, in comparison to those observed for the sample with the highest Si/Al ratio, and due to its higher bulk tetrahedral aluminum content, in comparison to the intermediate Si/Al ratio sample. All catalysts were selective to ethylene and diethyl ether, confirming the presence of acidic sites.
Distribution of lupus anticoagulant and anticardiolipin antibody isotypes in a population with antiphospholipid syndrome. (1999)

The presence of one or any mixture of isotype of aCL with or without LAC is not associated with the site of thrombosis (venous or arterial). On the contrary, in the patients with primary APS, the presence of the 3 aCL isotypes plus LAC was associated with a higher number of recurrent spontaneous abortions compared to other possible combinations of aCL isotypes.
THE BOOK OF MORMON IN LATTER-DAY SAINT HYMNODY (2000)

Research Article| April 01 2000 THE BOOK OF MORMON IN LATTER-DAY SAINT HYMNODY KAREN LYNN DAVIDSON KAREN LYNN DAVIDSON Search for other works by this author on: This Site Google Journal of Book of Mormon Studies (1992-2007) (2000) 9 (1): 14–77. https://doi.org/10.2307/44758903 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation KAREN LYNN DAVIDSON; THE BOOK OF MORMON IN LATTER-DAY SAINT HYMNODY. Journal of Book of Mormon Studies (1992-2007) 1 April 2000; 9 (1): 14–77. doi: https://doi.org/10.2307/44758903 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveUniversity of Illinois PressJournal of Book of Mormon Studies Search Advanced Search The text of this article is only available as a PDF. © 2000 Foundation for Ancient Research and Mormon Studies2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Photochromic spiropyrans. II. Emission spectra, intramolecular energy transfer, and photochemistry (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochromic spiropyrans. II. Emission spectra, intramolecular energy transfer, and photochemistryNorris W. Tyer Jr. and Ralph Sherman BeckerCite this: J. Am. Chem. Soc. 1970, 92, 5, 1295–1302Publication Date (Print):March 1, 1970Publication History Published online1 May 2002Published inissue 1 March 1970https://pubs.acs.org/doi/10.1021/ja00708a032https://doi.org/10.1021/ja00708a032research-articleACS PublicationsRequest reuse permissionsArticle Views575Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Seismic physical modeling at the University of Calgary (2009)

The seismic physical modeling facility at the University of Calgary has existed since 1985. Recently, we upgraded it by replacing obsolete components with modern alternatives. We constructed a 3D positioning system based on high‐precision linear electric motors, and coupled it to arrays of multiple transmitting and receiving piezoelectric transducers. We wrote customized software executing on the latest generation of desktop computers for controlling transducer movements, selecting and activating individual transducers, and acquiring and recording files of digital seismograms. The modernized facility enables us to collect scale‐model seismic gathers at rates of thousands of traces per hour. We present examples of data from modeled 2D marine and land seismic surveys.
Theoretical description and design of a fast-light enhanced helium-neon ring-laser gyroscope (2011)

We describe an enhanced rotation sensor involving an active helium-neon (HeNe) ring laser coupled to a passive enhancement resonator, which has been named a fast-light-enhanced HeNe ring-laser gyroscope (RLG). Theoretical rotation sensitivity enhancements as large as two orders of magnitude are presented. The physical effect responsible for the increased rotational sensitivity is the anomalous dispersion of the enhancement resonator, which produces a larger beat frequency as compared to a standard HeNe ring-laser gyroscope (RLG) as the laser cavity is rotated. We present the layout of the fast-light enhanced HeNe RLG, and we provide the theoretical modeling of the enhanced rotational sensitivity. A design is presented for the red HeNe (632.8 nm). The beat frequency is calculated with respect to rotation rate, which defines the useful range of operation for this highly sensitive RLG. Considerations for practical issues including laser-mirror reflectivity precision, unsaturated laser gain, and cavity-length stability are discussed.
Multiple-Point Simulation Applied to Uncertainty Analysis of Reservoirs Related to High Sinuosity Fluvial Systems: Mina El Carmen Formation, San Jorge Gulf Basin, Argentina* (2010)

A comparative study of several stochastic si mulation methods was performed in the reser voirs of the Upper Cretaceous Mina El Ca rmen Formation, in Diadema Field, located in the north flank San Jorge Gulf basin, Argentin a. The reservoirs belong to a meandering fluvial system showing high variability in thickness, ch annel width (less than well separation dist ance) and sinuosity parameters. The study c ompared the results of 30 realizations using Sequential Gaussi an Simulation, Sequential Indicator Simula tion, Object-Based and Multiple-point Seque ntial simulations (MPS) performed over the same facies data. The channe l probability three-dimensional models derived from the simula tions show a better and more realistic respons e of multiple-point methods over the previously widely used simulation methods. The SNESIM alg orithm was selected from the MPS methods available to simulate channel-fl ood plain facies. The model used to guide the MPS simulation was built using a current high-sinuosity fluvial system, the Sanboronbom River, located in Buenos Aires province, Argentina. The training model w as built by digitizing fluvial facies using sa tellite imagery and converted to ASCII format to be used in the SGems public software. The au thors believe that the Cretaceous Mina El Carmen Formation was deposited in a low sl ope environment similar to the ri ver used in the training mode l. After the realizations, the MPS probability model s hows channels with high sinuos ity, variable width, directi on changes and different siz es on the same stratigraphic level. These shapes were im possible to reproduce with the other simula tion methods mentioned above. Moreover, a good appraisal of a five-well forecast was made using the MPS probability model. It is concluded that the multiple-point method is most approp riate to estimate the uncertainty of high sinuosity fluvial syst ems with channel width less then 300 m in av erage, like the Mina El Carmen Format ion channels.
Squamous cell carcinoma complicating idiopathic inflammatory bowel disease (1995)

Squamous cell carcinoma of the colon and rectum, originating proximal to the transitional zone, is a rare complication of idiopathic inflammatory bowel disease (IIBD). To date there are only 15 single case reports of such an occurrence. This carcinoma develops more commonly in females and in patients with pancolonic disease of more than 8 years' duration. The rectum is affected in two thirds of the cases. Squamous cell changes, in the vicinity of the primary adenocarcinoma, are present in 27% of cases. The carcinoma is in a pathologically advanced stage in one third of the cases. Colectomy is the main therapeutic modality. Survival following surgical resection ranged from 7 months to 21 years. We present an additional case of rectal squamous cell carcinoma (SCC) complicating chronic ulcerative colitis in a 33-year-old woman who had the disease for 15 years. Multiple biopsies of a gross lesion located 5 cm above the dendate line were consistent with invasive basaloid cell carcinoma. The patient received 5-FU, mitomycin C, and radiotherapy prior to a proctocolectomy and ileostomy. The only histopathologic finding at pathologic review of the surgical specimen was severe squamous dysplasia.
Millimeter-wave transmitter and receiver using the nonradiative dielectric waveguide (2003)

Transmitter and receiver front ends have been fabricated in an integrated manner at 35 GHz, using a nonradiative dielectric waveguide (NRD guide). The structure and characteristics of various key components are described. Transmission testing over a ten-month period using the front ends has shown that the NRD guide integrated circuits are reliable in performance, moderate in size, and hence promising at millimeter wavelengths.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Enzymatic Preparation of Ginsenosides Rg<sub>2</sub>, Rh<sub>1</sub>, and F<sub>1</sub>from Protopanaxatriol-Type Ginseng Saponin Mixture (2003)

During investigations on the hydrolysis of a protopanaxatriol-type saponin mixture by various glycoside hydrolases, it was found that two minor saponins, ginsenosides Rg 2 and Rh 1, were formed in high yields by crude beta-galactosidase from Aspergillus oryzae and crude lactase from Penicillium sp., respectively. Moreover, a crude preparation of naringinase from Penicillium decumbens readily hydrolyzed a protopanaxatriol-type saponin mixture to give an intestinal bacterial metabolite, ginsenoside F 1 as the main product. A crude preparation of hesperidinase from Penicillium sp. selectively hydrolyzed ginsenoside Re into ginsenoside Rg 1. This is the first report on the enzymatic preparation of minor saponins, ginsenosides Rg 2 and Rh 1, and of an intestinal bacterial metabolite, ginsenoside F 1, with a high efficiency from a protopanaxatriol-type saponin mixture.
Insecticidal effects of insecticide, fungicide, complex fertilizer and wetting agent combinations depending on water hardness (2009)

Simultaneous occurrence of different harmful species in agricultural practice necessitates that different plant protection chemicals be applied at the same time (tank mix). Mix components differ in purpose, mode of action and/or formulation, while addition of no pesticide components (complex fertilizers, adjuvant and wetting agents) is widely practiced today. However, data concerning the effects of water quality used for preparation of working liquids on the biological effects of pesticides is still scarce. Therefore, the objective of this study was to determine insecticidal effects as depending on components used in mixes and water hardness. The effects of mixtures of thiametoxam (Actara 25-WG 0,07kg/ha) with azoxystrobin (Quadris 0.75 l/ha), mancozeb (Dithane M-70 2.5 kg/ha), a complex fertilizer (Mortonijc plus 3 kg/ha) and a wetting agent (Silwet L-77), depending on the components and water hardness (slightly hard (15.4 d?) - tap water from Novi Sad, and very hard (34.7 d?) - well water from Adica, a Novi Sad suburb), were determined in a bioassay based on adult mortality rate of the first generation of Colorado potato beetle (Leptinotarsa decemlineata Say). The mixtures were applied by a flooding method. The trial was set up to include four replications. Insecticidal effects were determined 24 h and 48 h after exposure. Thiametoxam effectiveness 24 h and 48 h after application in slightly hard water was 100% when the insecticide was applied alone and in double and triple mixes with the fungicides, complex fertilizer and wetting agent, showing no dependency on mix components. The tested adult population of Colorado potato beetle demonstrated high susceptibility to thiametoxam, while the other components had no impact in slightly hard water. In very hard water, 24 h after application, the insecticidal effect had the same level of significance to thiametoxam in double and triple mixes, with an exception of thiametoxam+mancozeb+Mortonijc plus and thiametoxam+mancozeb+wetting agent combinations, which showed significantly lower efficacy. After 48 h, substantially lower effectiveness, in comparison with the sole insecticide and other combinations, was only observed in thiametoksam+mancozeb+Mortonjic plus combination. Significantly lower efficacy of that combination is probably due to an incompatibility of the macozeb preparation and the complex fertilizer containing boron (B), which was evidenced only in very hard water.
The Determination of Flash Temperature in Intermittent Magnetic Head/Disk Contacts Using Magnetoresistive Heads: Part I—Model and Laser Simulation (1993)

The feasibility of using a magnetoresistive magnetic head to determine the flash temperature of intermittent magnetic head/disk contacts is investigated. A finite difference model is developed to study the effects of the magnetoresistive sensor height, the contact power intensity and the contact duration on the temperature response characteristics of the magnetoresistive sensor. A pulsed neody-minum:yttrium-aluminum-garnet laser is used as the heat source to simulate the contact and verify the model. The simulation results agree well with the theoretical model. Based on the theoretical model and laser simulation, a temperature sensitivity coefficient ζ is proposed to determine the surface temperature rise.
Clinical effects of porcine reproductive and respiratory syndrome virus on pigs during the early postnatal interval. (1998)

Because attenuated (vaccine) PRRSV can cause congenital infection and be transmitted postnatally from congenitally infected to immune-naive pigs, the use of attenuated virus during gestation is, at best, questionable.