gebhart/patrepeval huggingface dataset:
SYNTHESIS AND CONFIGURATION OF DIHYDROSPHINGOSINE<sup>1,2</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSYNTHESIS AND CONFIGURATION OF DIHYDROSPHINGOSINE1,2Herbert E. Carter, David Shapiro, and J. Bradley HarrisonCite this: J. Am. Chem. Soc. 1953, 75, 4, 1007–1008Publication Date (Print):February 1, 1953Publication History Published online1 May 2002Published inissue 1 February 1953https://pubs.acs.org/doi/10.1021/ja01100a522https://doi.org/10.1021/ja01100a522research-articleACS PublicationsRequest reuse permissionsArticle Views34Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of Orally Ingested<i>Bifidobacterium longum</i>on the Mucosal IgA Response of Mice to Dietary Antigens (1998)

To study the effects of lactic acid bacteria on the mucosal defence against dietary protein antigens, we compared the mucosal IgA responses to beta-lactoglobulin (beta-LG) of two groups of mice fed a whey protein diet with and without a culture condensate of Bifidobacterium longum. Both total IgA and anti-beta-LG IgA levels in tissue extracts of the small intestinal wall were significantly higher in mice fed the B. longum diet for 2 weeks than in control ones. Peyer's patch (PP) cells from B. longum-fed mice had a much larger increase in in vitro IgA production than ones from control mice. Furthermore, the in vitro IgA response to beta-LG was detected only when PP cells from B. longum-fed mice were assayed. These results suggest that orally ingested lactic acid bacteria may protect a host from invasion of the intestinal mucosa by dietary antigens that have escaped enzymatic digestion in the intestine.
Simultaneous stimulated Raman scattering and optical frequency mixing in lithium iodate (1979)

Efficient stimulated Raman scattering (SRS) has recently been achieved in lithium iodate (LiIO3) at kHz PRF’s, thereby producing substantial average output powers in the first and second Stokes lines. In this letter, we show that the same LiIO3 crystal that serves as the Raman medium can also be used to generate the second harmonics and sum frequencies of the pump and Stokes lines. By rotating a LiIO3 crystal placed inside a Nd : YAlO3 laser, we have successively generated phase-matched outputs at 0.54 μm (1.13 W), 0.565 μm (78 mW), 0.592 μm (685 mW), 0.622 μm (98 mW), and 0.655 μm (107 mW).
Time-Course of Vibratory Adaptation and Recovery in Cutaneous Mechanoreceptive Afferents (2005)

Extended suprathreshold vibratory stimulation applied to the skin results in a desensitization of cutaneous mechanoreceptive afferents. In a companion paper, we describe the dependence of the threshold shift on the parameters of the adapting stimulus and discuss neural mechanisms underlying afferent adaptation. Here we describe the time-course of afferent adaptation and recovery. We found that absolute and entrainment thresholds rise and fall exponentially during adaptation and recovery with time constants that vary with fiber type. slowly adapting type I (SA1) afferents adapt most rapidly, and pacinian (PC) afferents adapt most slowly, whereas rapidly adapting (RA) afferents exhibit intermediate rates of adaptation; SA1 fibers also recover more rapidly from adaptation than RA and PC fibers. We also showed that threshold adaptation is accompanied by a shift in the timing of the spikes within individual cycles of the adapting stimulus (i.e., a shift in the impulse phase). We invoked an integrate-and-fire model to explore possible mechanisms underlying afferent adaptation. Finally, we found that the time-course of afferent adaptation is more rapid than that of its psychophysical counterpart, as is the time-course of recovery from adaptation, suggesting that central factors play a role in the psychophysical phenomenon.
Carbon-13 Nuclear Magnetic Resonance Analysis of Model Compounds of Saturated End Groups in Polypropylene (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13 Nuclear Magnetic Resonance Analysis of Model Compounds of Saturated End Groups in PolypropyleneA. Zambelli, P. Locatelli, and G. BajoCite this: Macromolecules 1979, 12, 1, 154–156Publication Date (Print):January 1, 1979Publication History Published online1 May 2002Published inissue 1 January 1979https://pubs.acs.org/doi/10.1021/ma60067a033https://doi.org/10.1021/ma60067a033research-articleACS PublicationsRequest reuse permissionsArticle Views118Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A figure of merit for the analysis of spoken dialog systems (2002)

In this paper, a single metric, which we will call the figure of merit , for the quantitative analysis and comparison of spoken dialog systems is introduced. This figure of merit is the product of the weighted dialog accuracy (expressed as the rate of success) and the weighted dialog efficiency (expressed as the average number of concepts per turn). Actually, it is highly desirable to have a quick and accurate dialog. However, these two requirements are conflicting. That is, an improvement in efficiency is accomplished at the expense of accuracy or vice versa. This makes difficult to compare two different spoken dialog systems or tune a particular system. We believe that this figure of merit would avoid those difficulties. To illustrate its use, we consider spoken dialog systems with different dialog strategies and compare them by performing quantitative analysis based on the finate state models of information items using the proposed metric.
A biosensor for theophylline based on fluorescence detection of ligand-induced hammerhead ribozyme cleavage (2002)

Recently, Breaker and coworkers engineered hammerhead ribozymes that rearrange from a catalytically inactive to an active conformation upon allosteric binding of a specific ligand. To monitor cleavage activity in real time, we have coupled a donor-acceptor fluorophore pair to the termini of the substrate RNA of such a hammerhead ribozyme, modified to cleave in trans in the presence of the bronchodilator theophylline. In the intact substrate, the fluorophores interact by fluorescence resonance energy transfer (FRET). The specific FRET signal breaks down as the effector ligand binds, the substrate is cleaved, and the products dissociate, with a rate constant dependent on the concentration of the ligand. Our biosensor cleaves substrate at 0.46 min(-1) in 1 mM theophylline and 0.04 min(-1) without effector, and discriminates against caffeine, a structural relative of theophylline. We have measured the theophylline-dependence profile of this biosensor, showing that concentrations as low as 1 microM can be distinguished from background. To probe the mechanism of allosteric regulation, a single nucleotide in the communication domain between the catalytic and ligand-binding domains was mutated to destabilize the inactive conformation of the ribozyme. As predicted, this mutant shows the same activity (0.3 min(-1)) in the presence and absence of theophylline. Additionally, time-resolved FRET measurements on the biosensor ribozyme in complex with a noncleavable substrate analog reveal no significant changes in fluorophore distance distribution upon binding of effector.
Answering the President's Call (1999)

In the end, both academics and practitioners will find Transforming Government to be a valuable read.For the academic community, the book's development of the characteristics of successful organizational change points toward an emerging theory of organizational change and identifies important considerations that should guide future research.For practitioners, the book paints a realistic picture of the obstacles that face reinvention initiatives, but it also offers encouragement that such initiatives, when accompanied by strong leadership, can produce real, meaningful change.
Efficient methods for video coding and processing (2007)

This thesis presents several novel improvements to video coding algorithms, including block-based motion estimation, quantization selection, and video filtering. Most of the presented improvements are fully compatible with the standards in general use, including MPEG-1, MPEG-2, MPEG-4, H.261, H.263, and H.264. For quantization selection, new methods are developed based on the rate-distortion theory. The first method obtains locally optimal frame-level quantization parameter considering frame-wise dependencies. The method is applicable to generic optimization problems, including also motion estimation. The second method, aimed at real-time performance, heuristically modulates the quantization parameter in sequential frames improving significantly the rate-distortion performance. It also utilizes multiple reference frames when available, as in H.264. Finally, coding efficiency is improved by introducing a new matching criterion for motion estimation which can estimate the bit rate after transform coding more accurately, leading to better motion vectors. For fast motion estimation, several improvements on prior methods are proposed. First, fast matching, based on filtering and subsampling, is combined with a state-of-the-art search strategy to create a very quick and high-quality motion estimation method. The successive elimination algorithm (SEA) is also applied to the method and its performance is improved by deriving a new tighter lower bound and increasing it with a small constant, which eliminates a larger part of the candidate motion vectors, degrading quality only insignificantly. As an alternative, the multilevel SEA (MSEA) is applied to the H.264-compatible motion estimation utilizing efficiently the various available block sizes in the standard. Then, a new method is developed for refining the motion vector obtained from any fast and suboptimal motion estimation method. The resulting algorithm can be easily adjusted to have the desired tradeoff between computational complexity and rate-distortion performance. For refining integer motion vectors into half-pixel resolution, a new very quick but accurate method is developed based on the mathematical properties of bilinear interpolation. Finally, novel number theoretic transforms are developed which are best suited for twodimensional image filtering, including image restoration and enhancement, but methods are developed with a view to the use of the transforms also for very reliable motion estimation.
Ascochyta blight of chickpea in Australia: identification, pathogenicity and mating type (1999)

The aetiology of blight of chickpea in South Australia was studied following sporadic disease outbreaks over several years that had been tentatively identified as Phoma blight. Nine fungal isolates from diseased chickpeas were tested for pathogenicity in the glasshouse, of which two caused symptoms resembling those of Ascochyta blight. The two aggressive isolates were identified as Ascochyta rabiei based on morphological characteristics of cultures and RAPD analysis. This was further confirmed by successful mating to international standard isolates, which showed that the two Australian isolates were MAT1‐1. These isolates are accessioned as DAR 71767 and DAR 71768, New South Wales Agriculture, Australia. This is the first time that A. rabiei has been positively identified in commercial chickpeas in the southern hemisphere. The pathogen was found (in 1992) in only one of 59 seed samples harvested throughout Australia between 1992 and 1996 and tested using International Seed Testing Association methods. The teleomorph has not been found in Australia and results to date suggest that only one mating type is present. This suggests that quarantine restrictions on imported chickpea seed should be retained to prevent the introduction of the opposite mating type.
Cloning and Expression of a Murine Fascin Homolog from Mouse Brain (1995)

The fascins are a widely distributed family of proteins that organize filamentous actin into bundles. We have cloned, sequenced, and expressed the murine homolog. Fascin is most abundant in brain and is found in other tissues including uterus and spleen. The deduced open reading frame encodes a protein of 493 amino acids with a molecular mass of 54,412 Da. Previous solubility problems with bacterially expressed fascins were overcome by producing the mouse protein as a fusion with Escherichia coli thioredoxin. A method for cleaving the fusion protein and for purifying active recombinant fascin is described. The N-terminal sequence and molecular mass estimated on SDS gels indicate that recombinant fascin is full-length. Two-dimensional gel electrophoresis suggests that recombinant fascin is post-translationally modified in a manner similar to that observed in mouse brain. Recombinant fascin and the fusion protein are recognized by monoclonal anti-fascin antibodies and will bundle rabbit skeletal muscle F-actin in vitro at a stoichiometry of 4.1:1 actin to fascin. Electron cryomicroscopy images show that the reconstituted bundles are highly ordered. However, their fine structure differs from that of echinoid fascin-actin bundles. This structural difference can be attributed to fascin.
Estradiol-Inducible Squelching and Cell Growth Arrest by a Chimeric VP16-Estrogen Receptor Expressed in <i>Saccharomyces cerevisiae</i> : Suppression by an allele of PDR1 (1993)

We have constructed and characterized a flexible system for analyzing the phenomenon of squelching and estrogen receptor function in the yeast Saccharomyces cerevisiae. The A/B region of the human estrogen receptor was replaced with the transcriptional activating domain of VP16 and expressed in yeast cells from high-copy-number plasmids. Addition of hormone resulted in an immediate inhibition of expression (squelching) of a chromosomally integrated GAL1:lacZ reporter gene and the eventual arrest of cell growth (toxicity). In order to determine whether a relationship exists between toxicity and squelching, mutations were made in this chimeric receptor (VEO) and their effects on transcriptional activation, squelching, and toxicity were compared. A direct correlation was found between mutations in VEO that reduced VP16 transactivation ability in yeast cells and those that reduced both squelching and toxicity. Surprisingly, mutations in the DNA binding domain (DBD) of VEO dramatically reduced squelching and completely relieved toxicity, suggesting a role for the DBD in squelching and strengthening the correlation between squelching and toxicity. To demonstrate the utility of this system for carrying out genetic selection, a plasmid-based yeast genomic bank was screened for genes that can relieve the toxicity of VEO by means of an elevated copy number, resulting in the repeated cloning of an allele of the PDR1 (pleiotropic drug resistance) gene. We present evidence that mutations in PDR1 can modulate the intracellular availability of estradiol by the same mechanism that leads to multiple drug resistance in yeast cells. Taken together, our results provide evidence that cell growth arrest occurs when squelching exceeds a certain threshold and that strong squelching requires both a DBD and a transcriptional activating domain. Furthermore, we show that growth arrest can provide a useful phenotype for carrying out the genetic analysis of both squelching and estrogen receptor function in yeast cells.
An Essential Role of Antibodies in the Control of Chikungunya Virus Infection (2013)

In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV infection in both humans and mice, their exact role in the control of CHIKV infection remains unclear. In this study, wild-type (WT), CD4(-/-), and B cell (μMT) knockout mice were infected with CHIKV. Sera were taken at different days postinfection and measured for anti-CHIKV Ab levels. Isotype and neutralizing capacity of these Abs were assessed in vitro, and specific linear epitopes were mapped. Viremia in CHIKV-infected μMT mice persisted for more than a year, indicating a direct role for B cells in mediating CHIKV clearance. These animals exhibited a more severe disease than WT mice during the acute phase. Characterization of CHIKV-specific Abs revealed that anti-CHIKV Abs were elicited early and targeted epitopes mainly at the C terminus of the virus E2 glycoprotein. Furthermore, CD4(-/-) mice could still control CHIKV infection despite having lower anti-CHIKV Ab levels with reduced neutralizing capacity. Lastly, pre-existing natural Abs in the sera of normal WT mice recognized CHIKV and were able to partially inhibit CHIKV. Taken together, natural and CHIKV infection-induced specific Abs are essential for controlling CHIKV infections.
Dielectrically enhanced excitons in semiconductor-insulator quantum wires: Theory and experiment (2000)

We present both theoretical and experimental investigations of optical properties of excitons in semiconductor--insulator quantum wires. Spectra of linear and nonlinear absorption, photoluminescence and its polarization, photoluminescence excitation, time-resolved photoluminescence of GaAs, CdSe, and InP quantum wires 4--6 nm in diameter, crystallized in dielectric matrix, demonstrate the prominent excitonic behavior. In these structures an essential difference of dielectric constants of constituent materials leads to a considerable enhancement of excitons, the binding energies ranging from 120 meV to 260 meV and exciton transitions being well distinguished in nanowires with sufficient dispersion of diameter even at room temperature. A theoretical approach to calculations of the exciton parameters in a semiconductor--insulator cylindrical quantum wire of finite diameter is developed. This approach accounts for a band-gap renormalization due to the spatial confinement and self-image effect, as well as for a dielectric enhancement of the electron-hole interaction. The calculated exciton transition energies and absorption spectra are consistent with the experimental results.
Decision Trees for Complexity Reduction in Video Compression (2019)

This paper proposes a method for complexity reduction in practical video encoders using multiple decision tree classifiers. The method is demonstrated for the fast implementation of the `High Efficiency Video Coding' (HEVC) standard, chosen because of its high bit rate reduction capability but large complexity overhead. Optimal partitioning of each video frame into coding units (CUs) is the main source of complexity as a vast number of combinations are tested. The decision tree models were trained to identify when the CU testing process, a time-consuming Lagrangian optimisation, can be skipped i.e a high probability that the CU can remain whole. A novel approach to finding the simplest and most effective decision tree model called `manual pruning' is described. Implementing the skip criteria reduced the average encoding time by 42.1% for a Bjøntegaard Delta rate detriment of 0.7%, for 17 standard test sequences in a range of resolutions and quantisation parameters.
Force‐Induced Remnant Magnetization Spectroscopy for Specific Magnetic Imaging of Molecules (2011)

Molekülspezifisch ist die Bildgebung mithilfe des neuen im Titel genannten FIRMS-Verfahrens, bei dem die Magnetisierung von magnetischen Partikeln in Abhängigkeit einer externen Kraft gemessen wird. Weil magnetische Partikel, die durch die Krafteinwirkung abgespalten werden, nicht zum Signal beitragen, kann die Bindungsstärke als ein spektroskopischer Parameter für die spezifische Identifizierung von Molekülen und Zellen dienen.
Antibacterial, allelopathic and antioxidant activities of essential oil of<i>Salvia officinalis</i>L. growing wild in the Atlas Mountains of Morocco (2012)

Salvia officinalis (Common sage, Culinary sage) is an aromatic plant that is frequently used as a spice in Mediterranean cookery and in the food industry and as a traditional medicine for the treatment of several infectious diseases. The essential oils were obtained by two different methods [hydrodistillation (HD) and microwave (Mw)] from the aerial part of S. officinalis L. growing wild in Ourika-Marrakech in Morocco. Ourika is a large zone of the Atlas Mountains which is considered as a large reserve of Flora, especially medicinal and aromatic plants. The obtained oils were analysed by gas chromatography and gas chromatography-mass spectrometry and compared with that of Tunisia. Thirty-six compounds were identified from the Mw-extracted oil which accounted for 97.32% of the total oil composition. However, 33 compounds obtained by HD representing 98.67%. The major components were trans-thujone (14.10% and 29.84%), 1,8-cineole (5.10% and 16.82%), camphor (4.99% and 9.14%), viridiflorol (16.42% and 9.92%), β-caryophyllene (19.83% and 5.20%) and α-humulene (13.54% and 4.02%). Antibacterial, allelopathic (% germination in lettuce seeds and inhibited root growth obtained after treatment with S. officinalis oils) and antioxidant (IC₅₀ values 22 mg/mL) activities were studied.
Long wavelength quantum well lasers with InGaAs/InP superlattice optical confinement and barrier layers (1993)

Long wavelength, separate confinement heterostructure, ridge waveguide laser diodes using InGaAs/InP short period superlattices and InGaAs quantum wells have been demonstrated. The short period superlattices replace the more conventional quaternary alloys. These lasers have threshold current densities of 1.9kA/cm2, device efficiencies of 0.16mW/mA and a characteristic temperature T0 of 56 K.
Fulminant Hepatitis E in a Woman Taking Oral Contraceptive Medication (2010)

We describe a fulminant autochthonous hepatic failure caused by hepatitis E (HEV) in a patient admitted in our hospital for liver-transplant evaluation. The only risk factor recorded for this severe course was the use of oral contraceptives that are known to mimic a hormonal status similar to pregnancy. The diagnosis was based on the presence of IgG and IgM anti-HEV in the serum of the patient and confirmed by the isolation of a strain of HEV genotype 3f from a blood sample obtained the fourth day after hospital admission. HEV genotype 3 is present in human and swine populations in Spain. The patient began to recover while waiting for a liver transplant. To our knowledge, this is the first report of fulminant hepatitis E in a non-pregnant European patient on oral contraceptives.