gebhart/patrepeval huggingface dataset:
INVESTIGATION OF THE MECHANICS OF CARGO HANDLING BY AERIAL CRANE-TYPE AIRCRAFT (1966)

Abstract : The report covers an investigation into the mechanics of handling external cargo by helicopters. It comprises an analytical study of airborne hoist systems and comparisons of load acquisition techniques, crane-type long landing gears, and single- and multi-point suspension systems. The vertical bounce phenomenon is analyzed in detail and found to be dependent on inputs to the thrust control system provided by the pilot. The stability of the helicopter in forward flight is analyzed for neutrally stable slung loads. Forward-speed stability and control limits are usually the result of the effects of load aerodynamic instability on the handling qualities of the helicopter. For aerodynamically unstable loads, multi-point suspension allows a significant increase in forward speed over single-point suspension. A test plan describing equipment and associated items required to quantify and qualify the defined design parameters is included.
The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system? (2008)

The Leicester Cough Monitor: a semi
Bank Mergers and Acquisitions (2008)

As finance literature suggests, an option is valuable. The major finding of this study is that lockup options and collar offers in bank merger transactions are important terms in determining the bid premiums offered to the target, after controlling for the salient financial and deal-specific variables. The findings are somewhat consistent with Burch(2001) and Fuller(2003). This paper also finds that synergy is positively related to merger premiums, but the effect is significant only in intrastate mergers when large banks takeover relatively smaller banks. The structure cf the dealt pooling vs. purchase) and the credit quality of the target bank's portfolio seems to affect the target's value in bank takeover markets.
The Effect of Angelicae gigantis radix according to Heat-process on Anti-Oxidant and Anti-Thrombotic (2016)

Objectives： Arachidonic acid is control the thromboxane A2 (TXA2) and prostacycline (PGI2) synthesis, TXA2 increase lead to thrombus produced by induces platelet aggregation and vasoconstriction. Angelicae gigantis radix (RAR) is mainly used blood deficiency and stagnation. In previous studies, RAR has been reported that a vasodilating and blood clotting delay effects. In this study, investigate that anti-oxidant and anti-thrombotic effects of RAR by heat-process.Methods： The heated angelicae gigantis radix sample were made by 140, 180, and 220 ℃ and 4, 6, 9 and 12 min using water or 30% ethanol. The anti-oxidant effects were measured by total polyphenol, total flavonoid, DPPH and ABTS radical scavening activation. Anti-thrombotic effect conducted in samples that are determined to be effective through the anti-oxidant experiment such as angelicae gigantis radix roasted 180℃, and 220℃ and angelicae gigantis radix roasted with 30% ethanol 180℃, and 220℃.Results： Anti-oxidant parameters were efficacious in high temperature roasted AR. Also AR and EAR increased a inhibitory activity of FXa compared with RAR. The blood coagulation time of administration groups were significantly increased compare with control group. The TXB2 was significantly decreased in AR and EAR.Conclusions : We confirmed that whether AR and EAR administration has anti-oxidant and anti-thrombotic effect or not. As the results, AR and EAR were improved anti-oxidant effects and blood biochemistry compare with control group. This study provides scientific evidence that AR and EAR are have an anti-oxidant effect and anti-thrombotic effect, it expected that there is no difference between the two.
Benign Hematogone-Rich Lymphoid Proliferations Can Be Distinguished From B-Lineage Acute Lymphoblastic Leukemia by Integration of Morphology, Immunophenotype, Adhesion Molecule Expression, and Architectural Features (2000)

Distinction of normal B-lymphoid proliferations including precursors known as hematogones from acute lymphoblastic leukemia (ALL) is critical for disease management. We present a multiparameter assessment of 27 bone marrow samples containing at least 25% hematogones (range, 25%-72%) by morphologic review. We used flow cytometry to evaluate B-cell differentiation antigen and adhesion molecule expression and immunohistochemistry on clot sections to evaluate architectural distribution. Flow cytometry revealed that intermediately differentiated cells (CD19+, CD10+) predominated, followed in frequency by CD20+, surface immunoglobulin-positive cells, with CD34+, terminal deoxynucleotidyl transferase (TdT)-positive cells as the smallest subset. Adhesion molecules (CD44, CD54) were expressed more heterogeneously compared with expression in acute lymphoblastic leukemia. Immunohistochemistry revealed that CD34+, TdT-positive cells were dispersed without significant clustering, while CD20+ cells exceeded CD34/TdT-positive cells in 24 of 25 cases. This multidisciplinary study demonstrates that hematogone-rich lymphoid proliferations exhibit a spectrum of B-lymphoid differentiation antigen expression with predominance of intermediate and mature B-lineage cells, heterogeneity of adhesion molecule expression, and nonclustered bone marrow architectural distribution.
Compute Unified Device Architecture Application Suitability (2009)

Graphics processing units (GPUs) can provide excellent speedups on some, but not all, general-purpose workloads. Using a set of computational GPU kernels as examples, the authors show how to adapt kernels to utilize the architectural features of a GeForce 8800 GPU and what finally limits the achievable performance.
Kaleida Health utilization of new network technologies to deliver digital video (2002)

As the healthcare industry moves into the next millennium, new technologies in network infrastructure will allow for improved communication between all facets of the organization. Kaleida Health of Buffalo NY has implemented the foundation on which these new technologies will operate. Kaleida Health has evaluated their traditional network architecture and looked at solutions for improving performance not only for data, but also voice, video and digital imaging.
Rapid cardiac MRI using random radial trajectories (2008)

We introduce using Sparse MRI with random radial trajectories in order to allow MRI images reconstruction from a small number of acquired k-space data, so fulfilling the demands of dynamic MRI. Different random radial trajectories are generated by varying the parameters of the added random perturbations to the radial trajectories. Images reconstruction is performed using the non-linear Ll norm reconstruction. Entropy is computed for the reconstructed images, as a quantitative measure for the reconstructed image quality. Both phantom simulation and real cardiac images are used in our experiments. Our results show that more sparsely sampled images can be reconstructed with higher quality compared to using non-randomly sampled radial k-space trajectories.
Deployment of assistive living technology in a nursing home environment: methods and lessons learned (2013)

Lessons learned from this study were very useful for our research work and can serve as inspiration for developers and providers of assistive living services. They confirmed the importance of real deployment to evaluate assistive solutions especially with the involvement of professional caregivers. They also asserted the need for larger deployments. Larger deployments will allow to conduct surveys on assistive solutions social and health impact, even though they are time and manpower consuming during their first phases.
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages. (1989)

Previous studies of the human neuroblastoma cell line SK-N-SH had demonstrated the presence of and phenotypic interconversion (transdifferentiation) between two morphologically and biochemically distinct cell types: N (neuroblastic) cells with properties of noradrenergic neurons and S (substrate-adherent) cells with properties of melanocytes. Current studies have sought to test the generality of these findings among other cultured human neuroblastoma cell lines and to define further the S-cell phenotype and that of a newly identified, morphologically intermediate, I-type cell. Morphologically homogeneous populations (clonal sublines or subpopulations) of N, S, and I cells were isolated from five additional neuroblastoma cell lines and analyzed biochemically for neuronal, glial, and melanocytic marker enzyme activities and norepinephrine uptake. Immunoblot techniques were used to detect intermediate filament proteins (neurofilament protein, vimentin, glial fibrillary acidic protein) and fibronectin. All N-type cells exhibited neuronal marker enzyme activities, specific uptake of norepinephrine, and presence of one or more neurofilament proteins. S-type cells generally lacked neuronal characteristics but contained, instead, tyrosinase activity (a melanocytic marker enzyme), vimentin, and fibronectin. This combination of attributes is suggestive of a multipotent embryonal precursor cell of the neural crest. I-type cells differentially expressed both S- and N-cell properties and could represent either a stem cell or an intermediate in the transdifferentiation process. Studies of the biological significance of human neuroblastoma cell transdifferentiation and the molecular mechanisms underlying this process may be of relevance to the biological and clinical behavior of this tumor in the patient.
New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management (2017)

Pharmacological and cellular treatment of cancer is changing dramatically with benefits for patient outcome and comfort, but also with new toxicity profiles. The majority of adverse events can be classified as mild or moderate, but severe and life-threatening complications requiring ICU admission also occur. This review will focus on pathophysiology, symptoms, and management of these events based on the available literature.While standard antineoplastic therapy is associated with immunosuppression and infections, some of the recent approaches induce overwhelming inflammation and autoimmunity. Cytokine-release syndrome (CRS) describes a complex of symptoms including fever, hypotension, and skin reactions as well as lab abnormalities. CRS may occur after the infusion of monoclonal or bispecific antibodies (MABs, BABs) targeting immune effectors and tumor cells and is a major concern in recipients of chimeric antigen receptor (CAR) modified T lymphocytes as well. BAB and CAR T-cell treatment may also be compromised by central nervous system (CNS) toxicities such as encephalopathy, cerebellar alteration, disturbed consciousness, or seizures. While CRS is known to be induced by exceedingly high levels of inflammatory cytokines, the pathophysiology of CNS events is still unclear. Treatment with antibodies against inhibiting immune checkpoints can lead to immune-related adverse events (IRAEs); colitis, diarrhea, and endocrine disorders are often the cause for ICU admissions.Respiratory distress is the main reason for ICU treatment in cancer patients and is attributable to infectious agents in most cases. In addition, some of the new drugs are reported to cause non-infectious lung complications. While drug-induced interstitial pneumonitis was observed in a substantial number of patients treated with phosphoinositol-3-kinase inhibitors, IRAEs may also affect the lungs.Inhibitors of angiogenetic pathways have increased the antineoplastic portfolio. However, vessel formation is also essential for regeneration and tissue repair. Therefore, severe vascular side effects, including thromboembolic events, gastrointestinal bleeding or perforation, hypertension, and congestive heart failure, compromise antitumor efficacy.The limited knowledge of the pathophysiology and management of life-threatening complications relating to new cancer drugs presents a need to provide ICU staff, oncologists, and organ specialists with evidence-based algorithms.
The peri‐implant hard and soft tissues at different implant systems. A comparative study in the dog. (1996)

The aim of this study of the present experiment was to study the marginal periimplant tissues at intentionally non-submerged (1-stage implants) and initially submerged and subsequently exposed implants (2-stage implants). 5 beagle dogs, about 1-year-old, were used, 3 months after the extraction of the mandibular premolars, fixtures of the Astra Tech Implants Dental System, the Brånemark System and the Bonefit--ITI system were installed. In each mandibular quadrant, 1 fixture of each implant system was installed in a randomised order. The installation procedure followed the recommendations given in the manuals for each system. Thus, following installation, the bone crest coincided with the fixture margin of the Astra Tech Implants Dental System and the Brånemark System, whereas the border between the plasma sprayed and the machined surface of the Bonefit-ITI implant system was positioned at the level of the bone crest. Following a healing period of 3 months, abutment connection was carried out in the 2-stage systems (the Astra Tech Implants Dental System and the Brånemark system). A 6-month period of plaque control was initiated. The animals were sacrificed and biopsies representing each important region dissected. The tissue samples were prepared for light microscopy and exposed to histometric and morphometric measurements. The mucosal barrier which formed to the titanium surface following 1-stage and 2-stage implant installations comprised an epithelial and a connective tissue component, which for that 3 systems studied, had similar dimensions and composition. The amount of lamellar bone contained in the periimplant region close to the fixture part of the 3-implant systems was almost identical. It is suggested that correctly performed implant installation may ensure proper conditions for both and hard tissue healing, and that the geometry of the titanium implant seems to be of limited importance.
A current testing for CMOS static RAMs (2002)

RAM testing has become a crucial problem because the testing time becomes much longer with the increase of its capacity. In this paper, the authors propose a current testing for CMOS static RAMs. Firstly, to see what influence a fault has on a power supply current, they analyze the behavior of a single memory cell when a fault occurs. It is found that almost all faults affect power supply current when a write operation is executed. Based on this analysis, secondly, the authors discuss a current testing scheme, where an address decoder structure is modified such that a write operation can be simultaneously executed on all the memory cells in a testing mode. In this current testing scheme, since the whole memory cell array could be treated as if it were a single memory cell, the length of the test sequences is not dependent on the size of memory cell array and must be very short. Hence, the authors believe their current testing method is a promising candidate for testing CMOS static RAMs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On the Reliability of Half-Cell Tests for Monovalent (Li<sup>+</sup>, Na<sup>+</sup>) and Divalent (Mg<sup>2+</sup>, Ca<sup>2+</sup>) Cation Based Batteries (2017)

A comprehensive study is reported entailing a comparison of Li, Na, K, Mg, and Ca based electrolytes and an investigation of the reliability of electrochemical tests using half-cells. Ionic conductivity, viscosity, and Raman spectroscopy results point to the cationsolvent interaction to follow the polarizing power of the cations, i.e. Mg2+ &gt; Ca2+ &gt; Li+ &gt; Na+ &gt; K+ and to divalent cation based electrolytes having stronger tendency to form ion pairs - lowering the cation accessibility and mobility. Both increased temperature and the use of anions with delocalized negative charge, such as TFSI, are effective in mitigating this issue. Another factor impeding the divalent cations mobility is the larger solvation shells, as compared to those of monovalent cations, that in conjunction with stronger solvent - cation interactions contribute to slower charge transfer and ultimately a large impedance of Mg and Ca electrodes. An important consequence is the non-reliability of the pseudo-reference electrodes as these present both significant potential shifts as well as unstable behaviors. Finally, experimental protocols in order to achieve consistent results when using half-cell set-ups are proposed.
2'(or 3')-O-(2, 4, 6-Trinitrophenyl)adenosine 5'-Triphosphate as a Probe for the Binding Site of Heavy Meromyosin ATPase1 (1975)

1. From NMR, IR and visible absorption studies of 2'(or 3')-O-(2, 4, 6-trinitrophenyl)-adenosine 5'-triphosphate (TNP-ATP), 2'(or 3')-O-(2, 4, 6-trinitrophenyl) adenosine (TNP-Ad(, and 1-(2'-hydroxyethoxy)-2, 4, 6-trinitrobenzene (TNP-EG), it was concluded that there is an intramolecular interaction between the base and 2, 4, 6-trinitrophenyl (TNP) moieties in the TNP-ATP molecule. 2. A broad new absorption band was observed in the 530-630 nm region when excess indole was added to reaction mixtures containing TNP-ATP dissolved in 50% methanol or dimethyl sulfoxide. On addition of aromatic amino acid derivatives, methanol or dimethyl sulfoxide. On addition of aromatic amino acid derivatives, TNP-ATP and TNP-Ad underwent spectral shifts in the 400-550 nm region. The formation of a 1:1 complex apparently occurred between TNP-ATP and aromatic amino acid derivatives, and the complex with N-acetyltryptophan was stable in 50% methanol. The difference spectrum of TNP-EG vs. TNP-ATP closely resembled that induced by the addition of N-acetyltryptophan to the TNP-ATP solution. 3. The binding of 2'(or 3')-O-(2, 4, 6-trinitrophenyl)adenosine 5'-diphosphate (TNP-ADP) to heavy meromyosin (HMM) was studied by the rapid gel equilibrium method using Sephadex G-25. A dissociation constant of 1.4 muM and a maximum binding number of 1.8 were obtained in 0.15 M KCl, 10 mM MgCl2, and 50 mM Tris-HCl (pH 8.0) at 25 degrees. TNP-ADP bound to the enzyme caused a characteristic spectral shift in the visible region. This spectral shift was explained in terms of an interaction between tryptophanyl residues and the adenine base of TNP-ADP bound to the enzyme. TNP-ADP quenched the tryptophanyl fluorescence, but TNP-EG and TNP-Ad did not. In the presence of 6 M guanidine hydrochloride, TNP-ADP scarcely quenched the tryptophanyl fluorescence, its effect being comparable to that of TNP-Ad.
The Conversion of Waste Plastics/Petroleum Residue Mixtures to Transportation Fuels (2006)

This chapter contains sections titled: Introduction The Characteristics and Chemical Structure of Plastics The Characteristics and Chemical Properties of Petroleum Residue Technologies for Petroleum Residue Upgrading Technologies for Tertiary Recycling of Mixed Plastic Waste (MPW) Coprocessing for Fuel from Mixed Plastic Waste Pyrolysis Environmental Impacts of Recycling of Waste Plastics Economic Evaluation Conclusions References
Parallel transient analysis for circuit simulation (1996)

We discuss the application of domain decomposition methods to circuit simulation. This coarse grain parallelization guarantees low communication and this achieves good speedup results on a workstation cluster. The communication can be reduced to a minimum, especially with multilevel Newton methods and iteration latency techniques. The application of these techniques make our parallel implementation very well suited for a workstation cluster with low communication performance.
High Frequency of The Mage–1 Gene Expression in Hepatocellular Carcinoma (1996)

The MAGE–1 gene, originally isolated from a human melanoma cell line, directs the expression of a potential tumor–rejection antigen, MZ2–E. This antigen is recognized by autologous cytotoxic T lymphocytes in association with a major histocompatibility complex class I molecule (HLA–A1), and has provided a basis for specific immunotherapy for melanoma patients. Here we show a high frequency of expression of the MAGE–1 gene in hepatocellular carcinoma (HCC). We examined the expression of the MAGE–1 gene in cell lines originated from hepatoma cells and in tumor and nontumor tissues of livers with HCC by reverse–transcription polymerase chain reaction (RT–PCR) and subsequent Southern blotting. MAGE–1 messenger RNA (mRNA) was expressed in three of four HCC cell lines (75%) and in 16 of 20 (80%) resected HCCs though none was detected in nontumor tissues. The high frequency expression of MAGE–1 gene in HCCs suggests the possibility as a target for tumor– specific immunotherapy for HCC patients.
Prevention of murine cryoglobulinemia and associated pathology by monoclonal anti-idiotypic antibody. (1989)

A murine IgG3 mAb, clone 6-19, derived from non-manipulated autoimmune MRL/MpJ-lpr/lpr mice is a rheumatoid factor specific for IgG2a and is able to generate cryoglobulins via nonspecific IgG3 Fc-Fc interaction. Intraperitoneal passive transfer of ascites containing the 6-19 mAb into BALB/c mice induces, within 18 h, remarkable pathology characterized by skin vasculitis and acute glomerulonephritis associated with cryoglobulinemia. In order to evaluate the possibility of modulating the development of tissue lesions by an anti-Id antibody, we have raised an IgG2b anti-Id mAb specific to the 6-19 mAb. The cryoprecipitation of 6-19 mAb was completely inhibited in the presence of excess amounts of anti-Id mAb in vitro. In vivo, pretreatment of BALB/c mice with anti-6-19 anti-Id mAb inhibited development of skin vasculitis and glomerulonephritis induced by the 6-19 mAb. The cryoglobulin formation was markedly diminished due to enhanced elimination of the 6-19 mAb from the circulation. In contrast, pretreatment with an IgM anti-IgG3 rheumatoid factor mAb neither protected nor aggravated the development of tissue lesions. These results suggest possible implications in the anti-Id treatment of similar vascular diseases in man.
Bariatric surgery and taste: novel mechanisms of weight loss (2010)

Elucidation of the metabolic mechanism behind the alterations in taste after obesity surgery could lead to the development of novel surgical and nonsurgical procedures for the treatment of obesity.