gebhart/patrepeval huggingface dataset:
The Kinetics of the Reaction between Ascorbic Acid and Oxygen in the Presence of Copper Ion (1943)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Kinetics of the Reaction between Ascorbic Acid and Oxygen in the Presence of Copper IonEthel Silverblatt, A. L. Robinson, and C. G. KingCite this: J. Am. Chem. Soc. 1943, 65, 2, 137–141Publication Date (Print):February 1, 1943Publication History Published online1 May 2002Published inissue 1 February 1943https://pubs.acs.org/doi/10.1021/ja01242a002https://doi.org/10.1021/ja01242a002research-articleACS PublicationsRequest reuse permissionsArticle Views713Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Acyclovir in the treatment of herpesvirus infections (1983)

In a brief editorial note in the May 1982 issue of Postgraduate Medicine, we called attention to acyclovir, which had just been introduced and which gave promise of being an effective antiviral age...
ChemInform Abstract: 3‐(2‐Benzofuranyl)quinuclidin‐2‐ene Derivatives: Novel Muscarinic Antagonists. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Risk Management and Quality Management in Long‐Term Care Organizations: A Collaborative Model (2011)

Abstract The U.S. long‐term care system is complex and heavily regulated, yet incidences of risks continue to occur and result in lowered quality of care, and adversely affect patient safety. Risks can be minimized and avoided to safeguard the health and well being of consumers utilizing long‐term care services. The key component to minimizing risks and potential hazards and ensuring high quality in long‐term care facilities is to integrate quality management programs and quality improvement efforts with risk management activities. Currently, risk management and quality management are two distinct functions in long‐term care organizations. Although some activities may be linked, actual coordination and true integration have not taken place. Expansion and integration of risk management and quality improvement functions will result in more effectiveness for both areas. This paper develops a rational model to demonstrate that coordination and integration between risk management and quality management are essential to the delivery of cost effective and quality services in long‐term care organizations.
Biomechanische annäherung an die dysfunktion - Teil 1 (2007)

SCOPUS: ar.j
RAST-based allergen assay methods. (1975)

The RAST principle has been utilized for the detection and assay of allergens of various origins. RAST-based methods have the advantage of being convenient, accurate and specific by making use of the IgE antibodies, considered as mediators of the atopic allergic reactions, as reagents in vitro. Two improved assay procedures, a direct titration and an inhibition method, have been used for the estimation of extract potencies and for the assay of separate allergens. The specificity of the assays is determined by the specificity of the IgE (sera from allergic patients) used as the main reagent. Specific assay of separate components in heterogeneous extracts may be achieved in some cases by careful characterization of the sera or by selective blocking of irrelevant IgE. The potency of allergen concentration may be calculated and expressed in arbitrary units, and the accuracy and sensitivity of the two methods are similar. The coefficient of variation is in the range 10 to 25% provided that standardized reagents are used. Sensitivity of the assays is about 200 ng per ml. The lower limit for detection of allergen is 10-100 times lower.
3D scene reconstruction and object recognition for indoor scene (2019)

In recent years, many SLAM (simultaneous localization and mapping) systems have appeared showing impressive dense scene reconstruction. However, the normal SLAM system build 3D scenes at point level without any semantic information. Many computer vision applications require high ability of scene understanding and point-based SLAM shows insufficiency in these applications. This paper studies about fusing 3D object recognition into SLAM system, using hand-held RGB-D camera and RTAB-Map to reconstruct dense point cloud of 3D indoor scene. Then we use supervoxel based point cloud segmentation approaches to over-segment the scene. 3D object classification model trained by PointNet is added to merge the segmentation process and object recognition. Our experiment on indoor environment shows the effectiveness of this system.
Dependence of the electromechanical coupling on the degree of orientation of c-textured thin AlN films (2004)

Highly c-oriented thin aluminum nitride (AlN) films have been grown at room temperature with reactive sputter deposition. Membrane film bulk (FBAR) thickness excited resonators have been subsequently fabricated by bulk micro machining of silicon (Si). The resonators were then electrically characterized with a network analyzer in a one-port configuration. Subsequently, the coupling coefficients and the Q factors of both the longitudinal and the shear mode were extracted from fitting the measured admittance with that of the equivalent circuit model at the resonance frequencies. The goal of this work is to study the variation of the electromechanical coupling and the quality factor of the resonators, for both the longitudinal and the shear modes as a function of the degree of film texture. It is observed that the films exhibit a mean tilt of the c-axis relative the surface normal. This tilt is found to depend on both the film texture and the distance from the wafer radius. It is also demonstrated that the textured films exhibit a behavior of the electromechanical coupling effectively identical to that of a single crystalline material of equivalent tilt. Thus, it is shown that the electromechanical coupling for the longitudinal mode decreases from 8% to 4%, and that for the shear mode increases from 0% up to 3% by varying the full width half maximum (FWHM) of the [002] rocking curve in the interval from 2/spl deg/ to 10/spl deg/.
Detailed Comparison of Two Molecular Models of the Human CD40 Ligand with an X-ray Structure and Critical Assessment of Model-based Mutagenesis and Residue Mapping Studies (1998)

The interactions between the B cell receptor CD40 and its ligand on T cells are critical for the integrity of immune responses. The human CD40 ligand gp39, a tumor necrosis factor-like protein, has been the subject of intense efforts to identify the receptor-binding site and to analyze naturally occurring mutations that compromise gp39 function in vivo. These investigations relied heavily on molecular models of gp39, built in the presence of only approximately 25% sequence identity to tumor necrosis factor. The x-ray structure of gp39 has made it possible to assess modeling accuracy and to evaluate the results of model-based mutagenesis analyses. Although the models display local errors, their accuracy was sufficient to predict the CD40-binding site, to map natural mutations, and to rationalize their effects. One of five gp39 residues critical for CD40 binding was displaced in the models, and 1 of 21 point mutants was incorrectly classified. Factors most important for the reliability of the molecular models and their successful applications were valid sequence alignments and the focus of experimental studies on regions of high prediction confidence. Analysis of mutagenesis experiments correlated with anti-gp39 monoclonal antibody binding studies to assess the conformational integrity of mutant proteins.
Pharmacological treatments in ARDS; a state-of-the-art update (2013)

Despite its high incidence and devastating outcomes, acute respiratory distress syndrome (ARDS) has no specific treatment, with effective therapy currently limited to minimizing potentially harmful ventilation and avoiding a positive fluid balance. Many pharmacological therapies have been investigated with limited success to date. In this review article we provide a state-of-the-art update on recent and ongoing trials, as well as reviewing promising future pharmacological therapies in ARDS.
Plasminogen Activator in Bronchoalveolar Fluid (1986)

Plasminogen activator was purified from the soluble fraction of bronchoalveolar lavage fluid, and biological and immunological characteristics of the activator were examined by electrophoretic enzymography. The purified fraction showed a single band with a molecular weight of 53,000. The enzyme activity was eliminated in the presence of DFP and did not display fibrin affinity. Immunological tests revealed that the plasminogen activator reacted with IgG of antiurokinase but not with that of tissue-type plasminogen activator. However, the plasminogen activator cleaved S-2288 to a greater extent than S-2444 in contrast to urokinase.
Rapid and sensitive detection of multiple genes from the SARS-Coronavirus using quantitative RT-PCR with dual systems (2005)

The outbreak of severe acute respiratory syndrome (SARS) was caused by a newly identified coronavirus (SARS-CoV) in 2003. To detect early SARS-CoV infection, a one-step, real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) assay was developed that could simultaneously detect nucleocapsid (N), membrane (M), and spike (S) genes of SARS-CoV with the same PCR condition using either Applied Biosystems (ABI) Prism 7700 Sequence Detection System or Roche LightCycler. The sensitivity of this assay was evaluated using cell culture-derived viruses, in vitro transcribed viral RNA, and clinical specimens. The SARS-S, -M, and -N primer/probe sets described in this paper could detect one to ten copies of in vitro transcribed S, M, and N RNA per test using both the ABI and Roche assay systems. The relative sensitivities for detecting cell culture-derived SARS-CoV were 0.01, 0.01, and 0.001 PFU/test, respectively. It showed that SARS-N has comparable detection efficiencies to SARS2 and SARS3 which are primers sets designed by Centers for Disease Control and Prevention. In addition, SARS-S and SARS-M also demonstrated equivalent sensitivity to the commercially available RealArt HPA-Coronavirus reagents (Artus). The relative sensitivity of these primer/probe sets was also examined using human sera spiked viruses and clinical specimens from four confirmed SARS patients. Similar results as above were obtained. Specificity tests and sequence alignment showed that these primer/probe sets annealed perfectly to 31 isolates of SARS-CoV; and there was no cross detection with other coronaviruses and human respiratory tract-associated viruses. Therefore, not only is it compatible with the ABI and Roche systems, this multiple-gene detection assay also has the merit of being a rapid, safe, sensitive, and specific tool for accurate diagnosis of SARS-CoV infection. J. Med. Virol. 77:151–158, 2005. © 2005 Wiley-Liss, Inc.
Status and future developments in the physical aspects of hyperthermia. (1984)

The state of hyperthermia physics is reviewed. Major changes affecting the field are: (a) it is becoming far more sophisticated than just a few years ago, now that experts from many engineering and physical specialties are involved; (b) the ubiquitous computer is central to developments in data acquisition and analysis, treatment control, device comparison, treatment planning, and thermal dosimetry; and (c) entrepreneurial firms are arising to produce clinically engineered equipment. University and other research centers can concentrate their efforts on investigating new technologies up to the development of physical prototypes; they need no longer spend time on constructing complete clinical systems. At present, regional heating systems are unable to reliably induce therapeutic temperatures throughout the entire tumor volume. Interstitial techniques are able to accomplish this and so may make the greatest clinical impact in the near future. Invasive thermometry coupled with computerized data acquisition systems and numerical models appears to be a very promising approach to detailed thermal dosimetry. The tools for performing good clinical trials of hyperthermia are gradually becoming available.
Prolonged QT-Interval Syndromes (1986)

PROLONGATION of the QT interval, either on a congenital or an acquired basis, is associated with an increased likelihood of malignant ventricular arrhythmias.<sup>1-3</sup>Patients with QT prolongation frequently develop recurrent attacks of syncope or may present with sudden death. The malignant ventricular arrhythmias are characterized by rapid, irregular tachycardias that usually have a polymorphous configuration or a torsades de pointes pattern. The latter is a French term that describes the tachycardia as a "twisting of the points," so called because the QRS axis shifts back and forth around the baseline. Although polymorphous ventricular tachycardia and torsade frequently occur in the setting of QT prolongation, these malignant arrhythmias may also occur in the absence of a repolarization abnormality. Effective cardiac output and blood pressure are markedly impaired during torsades de pointes, with resultant syncope. Most tachyarrhythmic episodes terminate spontaneously with return of consciousness, but some may degenerate into ventricular fibrillation,
Insulin-Like Growth Factor (IGF)&slash;Somatomedin Receptor Subtypes: Structure, Function, and Relationships to Insulin Receptors and IGF Carrier Proteins (1986)

The insulin-like growth factors IGF-I and IGF-II are mitogenic polypeptides with a high degree of chemical homology. Two distinct subtypes of receptors for the IGFs have been identified on the basis of structure and binding specificity. Type I IGF receptors bind IGF-I with equal or greater affinity than IGF-II, and also bind insulin with a low but definite affinity. They are structurally homologous to insulin receptors, containing disulfide-linked a-subunits that bind the peptides and beta-subunits that have intrinsic tyrosine-specific kinase activity. Type II IGF receptors typically bind IGF-II with greater affinity than IGF-I, and do not interact with insulin. They consist of a single polypeptide and lack tyrosine kinase activity. Because of the extensive cross-reactivity of IGF-I and IGF-II with both type I and type II receptors, we believe that potentially either receptor may mediate the biological responses of either peptide. Type I IGF receptors have been shown to mediate the mitogenic effects of the IGFs in some cell types. Whether type II IGF receptors mediate the same or different functions remains to be elucidated.
COLLOIDAL RHODIUM IN POLY(VINYLPYRROLIDONE) AS HYDROGENATION CATALYST FOR INTERNAL OLEFINS (1978)

Abstract Refluxing of a methanol solution of rhodium(III) chloride and poly(vinylpyrrolidone) with sodium hydroxide gives a stable colloidal dispersion of rhodium particles of 8.8 Å in diameter. The colloidal dispersion exhibits a high catalytic activity for hydrogenation of internal olefins at 30°C under an atmospheric hydrogen pressure.
The Properties of Nitrile Binary Systems and their Relation to Polyacrylonitrile Solubility (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Properties of Nitrile Binary Systems and their Relation to Polyacrylonitrile SolubilityM. K. PhibbsCite this: J. Phys. Chem. 1955, 59, 4, 346–354Publication Date (Print):April 1, 1955Publication History Published online1 May 2002Published inissue 1 April 1955https://doi.org/10.1021/j150526a017RIGHTS & PERMISSIONSArticle Views261Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (903 KB) Get e-Alerts
Maleamic and Citraconamic Acids, Methyl Esters, and Imides (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMaleamic and Citraconamic Acids, Methyl Esters, and ImidesNARIMAN B. MEHTA, ARTHUR P. PHILLIPS, (MRS.) FLORENCE FU LUI, and RONALD E. BROOKSCite this: J. Org. Chem. 1960, 25, 6, 1012–1015Publication Date (Print):June 1, 1960Publication History Published online1 May 2002Published inissue 1 June 1960https://pubs.acs.org/doi/10.1021/jo01076a038https://doi.org/10.1021/jo01076a038research-articleACS PublicationsRequest reuse permissionsArticle Views1922Altmetric-Citations149LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cloning and expression of a human 14-3-3 protein mediating phospholipolysis. Identification of an arachidonoyl-enzyme intermediate during catalysis. (1992)

The major phospholipase A2 activity in sheep platelets is mediated by at least three chromatographically resolvable isoforms of a 30-kDa dimeric polypeptide which are responsive to physiologic increments in calcium ion and possess a dramatic substrate selectivity (Loeb, L. A., and Gross, R. W. (1986) J. Biol. Chem. 261, 10467-10470). Herein, we describe the cloning and expression of the human equivalent of one such isoform and demonstrate that it catalyzes the cleavage of the sn-2 fatty acid of choline and ethanolamine glycerophospholipids through the formation of a stable acyl-enzyme intermediate. Transesterification of the sn-2 acyl group of phosphatidylcholine to the recombinant 30-kDa polypeptide is over 50-fold selective for arachidonic acid, is augmented by calcium ion, and results in the formation of an arachidonoyl-thioester intermediate. Homology analysis demonstrated that the polypeptide mediating this transesterification is one member of a family of proteins collectively designated as 14-3-3 proteins. These results demonstrate that at least one intracellular mammalian phospholipase A2 employs a catalytic strategy distinct from that utilized by extracellular phospholipases A2 (i.e. formation of an acyl-enzyme intermediate by nucleophilic attack versus activation of a water molecule) and that arachidonic acid in endogenous phospholipid storage depots can, in principle, be sequentially transferred through an acyl-enzyme intermediate without the prior obligatory release of free arachidonic acid.
HPLC Separation of Acetaminophen and its Impurities Using A Mixed-mode Reversed-Phase/Cation Exchange Stationary Phase (2012)

Determination of acetaminophen and its main impurities: 4-nitrophenol, 4'-chloroacetanilide, as well as 4-aminophenol and its degradation products, p-benzoquinone and hydroquinone has been developed and validated by a new high-performance liquid chromatography method. Chromatographic separation has been obtained on a Hypersil Duet C18/SCX column, using gradient elution, with a mixture of phosphate buffer (pH = 4.88) and methanol as a mobile phase. Analysis time did not exceed 14.5 min and good resolutions, peak shapes and asymmetries have resulted. The linearity of the method has been tested in the range of 5.0-60 µg/mL for acetaminophen and 0.5-6 µg/mL for the other compounds. The limits of detection and quantification have been also established to be lower than 0.1 µg/mL and 0.5 µg/mL, respectively. The method has been successfully applied for the analysis of commercial acetaminophen preparations.
Performance Evaluation of Multi-Radio Transmission Diversity: QoS Support for Delay Sensitive Services (2009)

Integration and seamless networking of different wireless technologies is one of the driving scenarios in the contemporary research. In recent years, mobile phones have seen an influx of attractive on-demand multimedia services with strict QoS requirements. This work investigates the QoS for delay sensitive services under the design framework of a heterogeneous network. Multi Radio Transmission Diversity (MRTD), which exploits the benefits of dynamic usage of different access technologies, is tested using simulations for Voice-over-IP on multi-radio wireless devices. The network technologies in this study include HSDPA on UMTS and IEEE 802.11. By applying various MRTD schemes, gains in performance have been observed in terms of average packet delay, packet loss and goodput as compared to a legacy system which operates under only one network access for a given session. The MRTD schemes have been analyzed for various simulation scenarios characterized by varying traffic load and radio propagation conditions.