gebhart/patrepeval huggingface dataset:
Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression. (2000)

Protein or RNA synthesis inhibitors are known to sensitize some resistant cells for death receptor-induced apoptosis. However, the molecular mechanism(s) involved in sensitization have not yet been defined exactly. Here, we report that metabolic inhibitors such as cycloheximide (CHX) or actinomycin D (ActD) sensitize for CD95-induced apoptosis by strongly down-regulating FLIP and RIP expression. Metabolic labeling studies revealed that CHX or ActD inhibited protein or RNA synthesis at concentrations required for sensitization. In contrast to Fas-associated death domain (FADD) or caspase-8, FADD-like interleukin 1-converting enzyme-inhibitory protein (FLIP) and RIP protein levels rapidly decreased upon treatment with CHX or ActD, indicating that both molecules have a high turnover rate. Selective down-regulation of FLIP expression by FLIP antisense oligonucleotides sensitized for CD95-induced apoptosis. Reduction of FLIP levels resulted in undetectable amounts of FLIP at the CD95 death-inducing signaling complex (DISC) upon CD95 stimulation, thereby enhancing the recruitment of caspase-8 to the DISC and caspase-8 activation. CHX- or ActD-mediated sensitization to CD95-induced apoptosis was predominantly found in type I cells in which FADD and caspase-8 are recruited to CD95 upon stimulation but not in type II cells in which no DISC formation is detected. Pretreatment with CHX or ActD sensitized for subsequent CD95 stimulation compared with cells without pretreatment. CHX or ActD also reduced XIAP expression and similarly sensitized for tumor necrosis factor-related apoptosis-inducing ligand- or tumor necrosis factor-alpha-induced apoptosis. Because blockade of death receptor triggering by FLIP overexpression has recently been implicated in tumorigenesis and treatment resistance in vivo, strategies to inhibit FLIP expression, e.g., by metabolic inhibitors, may prove to be a useful complementary tool for the treatment of cancer.
Color segmentation by hierarchical connected components analysis with image enhancement by symmetric neighborhood filters (2002)

The authors introduce a general-purpose procedure for image segmentation which combines iterative image enhancement by a symmetric neighborhood filter (SNF) with an iterative, hierarchical connected component (HCC) analysis. Color vector versions of both SNF and HCC are developed, using two common kinds of metrics applied to color vector intensity differences-a simple Euclidean-type metric and a coordinate maximum-type metric. The segmentation procedures are illustrated with three-band color images of indoor and outdoor scenes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reversed vesicles from biocornpatible surfactants (1992)

The combination of hydrophilic and lipophilic amphiphiles and the addition of a small amount of water is demonstrated to be an effective method for the production of inversed vesicles (see figure) from biocompatible surfactant systems. Stable reversed vesicles would have applications in, for example, foods, medicines and cosmetics. magnified image
<i>Mycoplasma pneumoniae</i> DNA gyrase genes (1990)

We have identified a clone from a lambda EMBL3 library containing a 19kb insert of Mycoplasma pneumoniae DNA which includes the genes that encode both subunits of DNA gyrase. The gyrB gene and the 5' end of the gyrA gene have been subcloned into M13. The gyrB gene is 1953bp in length and overlaps the gyrA gene by a single base. The nucleotide sequence of these subclones has significant homology to previously reported gyrase genes. In terms of the size of the gyrB gene and its proximity to the gyrA gene, M. pneumoniae is more similar to Bacillus subtilis than to Escherichia coli.
Chemical release control—Schiff bases of perfume aldehydes and aminostyrenes (1982)

Abstract Schiff bases of p ‐ and m ‐aminostyrenes with perfume aldehydes such as citral, cinnamaldehyde, piperonal, vanillin, and ethyl vanillin were synthesized in ethanol in more than 50% yield. Water‐soluble copolymers of these Schiff bases with N ‐vinyl‐2‐pyrrolidone or with N , N ‐dimethylacrylamide were obtained. The hydrolytic behavior of Schiff base monomers and copolymers to liberate perfume aldehydes was structure dependent, thereby affording chemical release control.
Self-limiting laser thermal process for ultra-shallow junction formation of 50-nm gate CMOS (2004)

We have developed a novel LTP (laser thermal process) that dramatically enhances the laser exposure window by controlling the heating process in a self-limiting way (SL-LTP). The Vth roll-offs of MOSFETs formed by this method were remarkably improved compared to those by RTA when offset-spacer and halo-implantation processes were not applied. Its effectiveness was also verified in 50-nm gate CMOS devices for the first time by confirming that the drain current increased with laser fluence beyond the conventional exposure limit.
Net hepatic and splanchnic metabolism of lactate, pyruvate and propionate in dairy cows <i>in vivo</i> in relation to lactation and nutrient supply (1980)

1. Circulating concentrations of glucose, propionate, lactate and pyruvate, and net exchange of these compounds across the liver and gut, were measured in lactating and non-lactating dairy cows (a) in the normal fed state, (b) before, during and after intravenous infusion of an aqueous solution of glucose, propionate or lactate (lactating cows only) in fed animals, and (c) before and during 6 days of food deprivation. 2. In the normal fed state, gut output of propionate, hepatic output of glucose and hepatic uptake of lactate were all higher in the lactating group. There was a net uptake of pyruvate across the liver in the lactating cows and a net output in the non-lactating cows. In the lactating cows there was a net uptake of lactate and pyruvate by the splanchnic bed (i.e. gut and liver combined). 3. In the lactating cows, the glucose and propionate infusions had the following effects: decrease in net hepatic uptake of lactate; a switch in pyruvate exchange across the liver from uptake to output; suppression of uptake of lactate and pyruvate by the splanchnic bed; increase in the magnitude of the liver (propionate uptake)/(glucose output) ratio. Lactate infusion did not affect hepatic propionate uptake. 4. Food deprivation increased hepatic extraction of lactate and pyruvate and decreased the liver (propionate uptake)/(glucose output) ratio in both groups. 5. It is concluded that mechanisms exist to ensure an inverse relationship between the availability to the cow of glucose or propionate and utilization by the splanchnic bed of endogenously derived lactate and pyruvate.
Dopamine Receptor Transcript Expression in Striatum and Prefrontal and Occipital Cortex (1997)

Cortical dopaminergic neurotransmission may be disrupted in schizophrenia at the level of receptor expression. There appears to be a focal abnormality of D3 and D4 messenger RNA expression in the prefrontal cortex, with down-regulation of both, consistent with prefrontal cortical hypodopaminergia in schizophrenia.
Coupling of Soils and Vegetation in Peatland Succession (1996)

Lee F. Klinger, Coupling of Soils and Vegetation in Peatland Succession, Arctic and Alpine Research, Vol. 28, No. 3, Arctic Soils and Permafrost: Special Issue in Memory of Kaye R. Everett (Aug., 1996), pp. 380-387
Chromatin Remodeling by the Thyroid Hormone Receptor in Regulation of the Thyroid-stimulating Hormone α-Subunit Promoter (2001)

The chromatin architecture of a promoter is an important determinant of its transcriptional response. For most target genes, the thyroid hormone receptor (TR) activates gene expression in response to thyroid hormone (T(3)). In contrast, the thyroid-stimulating hormone alpha-subunit (TSH alpha) gene promoter is down-regulated by TR in the presence of T(3). Here we utilize the capacity for the Xenopus oocyte to chromatinize exogenous nuclear- injected DNA to analyze the chromatin architecture of the TSH alpha promoter and how this changes upon TR-mediated regulation. Interestingly, in the oocyte, the TSH alpha promoter was positively regulated by T(3). In the inactive state, the promoter contained six loosely positioned nucleosomes. The addition of TR/retinoid X receptor together had no effect on the chromatin structure, but the inclusion of T(3) induced strong positioning of a dinucleosome in the TSH alpha proximal promoter that was bordered by regions that were hypersensitive to cleavage by methidiumpropyl EDTA. We identified a novel thyroid response element that coincided with the proximal hypersensitive region. Furthermore, we examined the consequences of mutations in TR that impaired coactivator recruitment. In a comparison with the Xenopus TR beta A promoter, we found that the effects of these mutations on transactivation and chromatin remodeling were significantly more severe on the TSH alpha promoter.
Mutual‐information‐based image to patient re‐registration using intraoperative ultrasound in image‐guided neurosurgery (2008)

An image-based re-registration scheme has been developed and evaluated that uses fiducial registration as a starting point to maximize the normalized mutual information (nMI) between intraoperative ultrasound (iUS) and preoperative magnetic resonance images (pMR). We show that this scheme significantly (p<0.001) reduces tumor boundary misalignment between iUS pre-durotomy and pMR from an average of 2.5 mm to 1.0 mm in six resection surgeries. The corrected tumor alignment before dural opening provides a more accurate reference for assessing subsequent intraoperative tumor displacement, which is important for brain shift compensation as surgery progresses. In addition, we report the translational and rotational capture ranges necessary for successful convergence of the nMI registration technique (5.9 mm and 5.2 deg, respectively). The proposed scheme is automatic, sufficiently robust, and computationally efficient (<2 min), and holds promise for routine clinical use in the operating room during image-guided neurosurgical procedures.
Regulation of human chorionic gonadotropin secretion and messenger ribonucleic acid levels by follistatin in the NUCC-3 choriocarcinoma cell line. (1994)

In this study, the NUCC-3 choriocarcinoma cell line was used as an in vitro placental cell model to investigate the effects of follistatin on basal and GnRH-stimulated hCG secretion and/or its subunit mRNA levels. Follistatin (1.5-100 ng/ml; 48 h) alone did not affect basal hCG secretion or its subunit mRNA levels. GnRH increased hCG secretion and hCG beta-subunit mRNA levels in a dose-dependent manner, with maximal effects (2.37- and 2.4-fold increases, respectively) at a dose of 10(-8) M after 24 h of culture (P < 0.001). The time-course study showed that the increase in hCG secretion induced by GnRH occurred between 6-48 h after treatment. Follistatin (6-100 ng/ml; 48 h) significantly suppressed GnRH-stimulated hCG secretion and hCG alpha- and beta-subunit mRNA levels, with maximal suppression of 73.1%, 106.9%, and 129.1%, respectively (P < 0.001). In addition, follistatin (25 ng/ml) inhibited hCG secretion in response to phorbol 12-myristate 13-acetate (100 nM) by 90.3%. However, follistatin had no effect on hCG secretion evoked by forskolin (10 microM), and no change in hCG secretion was observed after treatment with a calcium ionophore (A23187; 10 microM) alone or in combination with follistatin. Furthermore, there was no significant difference in the half-lives of hCG alpha and -beta mRNA induced by GnRH alone compared with those induced by GnRH plus follistatin (P > 0.1), indicating that follistatin did not affect the stability of hCG alpha and -beta mRNA. Our data suggest that follistatin inhibits GnRH-stimulated hCG secretion as well as hCG alpha- and beta-subunit mRNA levels in the NUCC-3 choriocarcinoma cell line by decreasing the rate of transcription through the second messenger transduction system-protein kinase-C, rather than by affecting the stability of mRNA. These findings indicate that follistatin may play an important role in the regulation of hCG production in the placenta during pregnancy.
Donepezil in Alzheimer’s Disease: What to Expect after 3 Years of Treatment in a Routine Clinical Setting (2006)

Three-year donepezil treatment showed a positive global and cognitive outcome in the routine clinical setting.
<title>Hyperacuity laser printer</title> (1993)

A hyperacuity laser imager utilizes gray source data and overscanned gray exposure to achieve fully saturated black and white image rendering on the photoreceptor at 4800 addressability in both the fast and the slow scan directions, while maintaining 400 lines per inch frequency response. Conventional laser printing techniques render bitmapped images at resolutions finer than required by the human visual system (for example, 600 to 1200 bits per inch) in an unsuccessful attempt to meet a related requirement for edge placement precision of text, line art, and halftones. This excessive bitmapped resolution is inefficient and cumbersome to maintain in a printing system and is still not nearly enough to satisfy the human visual system's need for edge precision. On the other hand, a hyperacuity imager has the edge precision necessary to satisfy the human visual system's needs, and trades off excessive resolution to do so. This paper examines the overscanned, gray exposure characteristics of the hyperacuity laser imager and how it can be viewed as a natural evolution of the current trends in laser printing technology. In addition, it establishes an order of magnitude relationship between addressability and frequency response for a hyperacuity imager, which is shown to significantly match the needs of the human visual system.
Randomised, open label, controlled trial of celecoxib in the treatment of acute migraine. (2007)

In comparison with naproxen sodium, celecoxib was equally effective in relieving pain in acute migraine and caused significantly less gastric pain.
Graphene oxide modified metallic lithium electrode and its electrochemical performances in lithium–sulfur full batteries and symmetric lithium–metal coin cells (2016)

In this work, GO layers are successfully fabricated on the surface of lithium metal by a facile automatic spreading method. The GO/Li electrode displays enhanced electrochemical performances than the unmodified pure Li electrode.
On the complexity of bounded-variable queries (extended abstract) (1995)

Article Free Access Share on On the complexity of bounded-variable queries (extended abstract) Author: Moshe Y. Vardi Dept. of Computer Science, MS 132, 6100 Main St., Rice University, Houston, TX Dept. of Computer Science, MS 132, 6100 Main St., Rice University, Houston, TXView Profile Authors Info & Claims PODS '95: Proceedings of the fourteenth ACM SIGACT-SIGMOD-SIGART symposium on Principles of database systemsMay 1995 Pages 266–276https://doi.org/10.1145/212433.212474Published:22 May 1995Publication History 129citation504DownloadsMetricsTotal Citations129Total Downloads504Last 12 Months21Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Is Toyota's brand cracking : global auto crisis (2010)

Scarcely had it assumed the mantle of the world's largest automotive company than Toyota had to stare down its worst crisis in its history: the recall of millions of vehicles for sticky accelerator pedals.
Commissioning and quality assurance of the Pinnacle<sup>3</sup>radiotherapy treatment planning system for external beam photons (2003)

The commissioning of a Pinnacle(3) treatment planning system is described. Four Elekta linear accelerators were commissioned for external beam photons. Measured data were used to derive parameter values for the Pinnacle(3) beam model by (1). fitting a Monte Carlo model of the accelerator head to measured data and then extracting the parameters for the Pinnacle(3) beam model, and by (2). using the auto-modelling facility within Pinnacle(3). Both of these methods yielded dose distributions in accord with published recommendations. A separate small-field beam model, customized for an in-house compact blocking system, was also created, which satisfied appropriate acceptance criteria for stereotactically guided conformal brain treatments. Inhomogeneous, oblique, asymmetrical and irregular fields were also assessed, with calculated and measured doses agreeing to within +/-3%. Dose-volume histogram calculation was found to be accurate to within +/-5% dose or volume for a grid size of 4 mm x 4 mm x 4 mm, with better accuracy being achieved for finer grids. Isocentric doses were compared between Pinnacle(3)'s collapsed cone convolution algorithm and the Bentley-Milan algorithm within the Target-2 treatment planning system. Dose differences were generally less than 3% in the dose prescribed, with larger values for breast plans, where the Pinnacle(3) algorithm calculated scatter more accurately. Pelvic and thoracic plans were also verified using an anthropomorphic phantom, with local dose differences between calculated and delivered dose of up to 8%, but mainly less than 3%, and with no systematic difference. Ionization chamber verifications using START and RT-01 trial procedures demonstrated differences between calculated and measured doses of less than 2%. Following satisfactory performance in the commissioning process, Pinnacle(3) has now been introduced into routine clinical use.
The design and construction of tunnel diodes (1961)

The electrical characteristics and principle of operation of two types of tunnel device are described: the tunnel diode and the uni-tunnel or backward diode. The considerations governing choice of base and alloying materials are discussed. Details are given of the processes used to manufacture germanium and gallium arsenide devices, particular attention being given to the method of achieving close tolerance of the peak current of tunnel diodes by a monitored etching technique. Results are presented which show the influence of processing parameters on device characteristics. The equivalent circuits of the devices are related to the basic properties of the elements and their encapsulation.
Application of organic-inorganic polymer hybrids as selective gas permeation membranes (1999)

The gas permeability of polymer hybrid membranes has been investigated. The membranes were prepared by dip-coating a methanol solution of poly(N-vinylpyrrolidone) (PVP) and methyltrimethoxysilane (MTMOS) on porous glass tubes. The permeance was measured by using N 2 , CO 2 and He separately at a pressure of 1 kg cm –2 . It was found that the permeance of these gases all increased with temperature in the PVP hybrid membranes. In particular, the permeance of He increased at a much greater rate with temperature, resulting in high selectivity against N 2 . For instance, the permeance of He is 150 times greater than that of N 2 at 100 °C. The results indicate the dense structure of PVP hybrid membranes as confirmed by SEM observations. The hybrid membranes also exhibited high selectivity of CO 2 against N 2 . This could be attributed to the high polarity of amide groups in PVP chains which would facilitate the sorption of CO 2 . These polymer hybrid membranes were also found to have high thermal stability compared to organic polymer membranes.
High-coercivity longitudinal recording medium prepared using non-heating process (2001)

To get high coercivity in a longitudinal recording medium prepared at a low temperature, we found that a Ru underlayer is effective to enhance the coercivity for Co-Pt-based thin films. Increasing the Ru underlayer thickness and Pt composition of the magnetic layer increases coercivity. The introduction of boron and oxygen into the magnetic layer induces the segregation of grains.
The Preparation and Nuclear Magnetic Resonance of Krypton Difluoride<sup>1</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation and Nuclear Magnetic Resonance of Krypton Difluoride1F. Schreiner, J. G. Malm, and J. C. HindmanCite this: J. Am. Chem. Soc. 1965, 87, 1, 25–28Publication Date (Print):January 1, 1965Publication History Published online1 May 2002Published inissue 1 January 1965https://pubs.acs.org/doi/10.1021/ja01079a006https://doi.org/10.1021/ja01079a006research-articleACS PublicationsRequest reuse permissionsArticle Views151Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recognition of live-scan fingerprints with elastic distortions using correlation filters (2004)

A special NIST database of live-scan fingerprints with elastic distortion was prepared. It is used to evaluate the effect of elastic and other distortions on correlation filters. The need for normalized and finely or coarsely rotationally aligned data is addressed, and performance gains for various cases noted.
The numerical evaluation of radiation integrals (1961)

In the numerical evaluation of radiation integrals, the number of terms required depends on the accuracy desired, the method of integration, the current distribution on the antenna, the length of the antenna, and the observation angle. Simpson's rule and the trapezoidal rule appear to be used almost exclusively at present. A "piecewise linear rule" introduced here is shown to yield greater accuracy for a given calculation time.
C-Reactive Protein and the Incidence of Macular Degeneration: Pooled Analysis of 5 Cohorts (2013)

Overall, these pooled findings from 5 prospective cohorts add further evidence that elevated levels of hsCRP predict greater future risk of AMD. This information might shed light on underlying mechanisms and could be of clinical utility in the identification of persons at high risk of AMD who may benefit from increased adherence to lifestyle recommendations, eye examination schedules, and therapeutic protocols.