gebhart/patrepeval huggingface dataset:
CacyBP IS PRESENT IN NEURONS OF RAT BRAIN (2000)

Conference Abstract| October 01 2000 CacyBP IS PRESENT IN NEURONS OF RAT BRAIN Beata Jastrzebska; Beata Jastrzebska 1Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02–093 Warsaw, Poland E-mail: Bcataj@nencki.gov.pl Search for other works by this author on: This Site PubMed Google Scholar Anna Filipek; Anna Filipek 1Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02–093 Warsaw, Poland Search for other works by this author on: This Site PubMed Google Scholar Dorota Nowicka; Dorota Nowicka 1Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02–093 Warsaw, Poland Search for other works by this author on: This Site PubMed Google Scholar Leszek Kaczmarek; Leszek Kaczmarek 1Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02–093 Warsaw, Poland Search for other works by this author on: This Site PubMed Google Scholar Jacek Kuznicki Jacek Kuznicki 1Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02–093 Warsaw, Poland Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A443. https://doi.org/10.1042/bst028a443 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Beata Jastrzebska, Anna Filipek, Dorota Nowicka, Leszek Kaczmarek, Jacek Kuznicki; CacyBP IS PRESENT IN NEURONS OF RAT BRAIN. Biochem Soc Trans 1 October 2000; 28 (5): A443. doi: https://doi.org/10.1042/bst028a443 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Regulatory Role of Nitric Oxide on Monocyte-Derived Dendritic Cell Functions (2003)

Nitric oxide (NO) has an established role in the defense against bacterial infections and exerts multiple modulatory activities on both inflammatory and immune responses. However, the relevance of NO on dendritic cell (DC) functions has been poorly investigated. In this study, we found that addition of the NO donor S-nitrosoglutathione (GSNO) to monocyte-derived DCs matured by lipopolysaccharide (LPS) or soluble CD40 ligand led to a decreased capacity to activate naive allogeneic T cells but a more prominent Th1 polarization, with increased interferon-gamma (IFN-gamma) secretion and reduced interleukin-5 (IL-5) release. The presence of GSNO during maturation of DCs caused a reduced expression of surface CD86, whereas CD80, CD83, and MHC molecule expression was not affected. Moreover, GSNO induced a dose-dependent decrease of IL-10 and enhancement of tumor necrosis factor-alpha (TNF-alpha) release from mature DCs. In parallel, a marked reduced production of IL-12 p40 subunit but no significant perturbation of the bioactive IL-12 p70 production was observed. Finally, GSNO significantly reduced the release of IP-10/CXCL10 and RANTES/CCL5 but not IL-8/CXCL8 by mature DCs. Although GSNO can strengthen the capacity of mature DCs to induce type 1 polarization of T lymphocytes, our data suggest that it elicits distinct anti-inflammatory functions, eventually reducing T lymphocyte proliferation and recruitment.
Modelling the deformation mechanisms, structure–property relationships and applications of auxetic nanomaterials (2005)

Abstract Analytical and Molecular Mechanics methods have been used to study the structure and deformation mechanisms acting at the molecular level in the auxetic polymorph of crystalline silica (α‐cristobalite). The Molecular Mechanics simulations indicate a stress‐induced phase transition from α‐cristobalite to ‘ordered’ β‐cristobalite occurs for uniaxial loading along the x 3 direction. This is in reasonable agreement with the previous prediction from an analytical model assuming deformation is by concurrent dilation and cooperative rotation (about axes in the x 1 ‐ x 2 plane, passing through the midpoints of opposing edges – the a ‐axes) of the SiO 4 tetrahedral molecular sub‐units, previously shown to predict the Poisson's ratio for loading in the x 3 direction. The analytical models have been extended to include cooperative rotation of each tetrahedron about its axis (the c ‐axis) mostly closely aligned with the principal unit‐cell x 3 ‐axis. The new models enable significantly improved prediction of the Poisson's ratios of α‐cristobalite when loaded in one of the transverse ( x 1 or x 2 ) directions. Parametric fitting of the analytical models indicate that the deformation mechanism for transverse uniaxial loading of α‐cristobalite is by concurrent dilation and cooperative rotation about the local a and c ‐axes of the SiO 4 tetrahedra. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Forge and Direct Heat Treatment Processes and Technologies (2014)

Abstract This article provides general information on the definition, purposes, and quench equipment for direct-forge quenching (DFQ) and direct heat treatment (DHT) processes that are widely used in automotive and various other mechanical industries. It discusses the technological advances in these processes and their ability to produce high-quality components at low production cost from microalloyed steels. Further, the article describes the influence of carbon contents on toughness of microalloyed direct heat treated steels. It focuses on the DFQ and DHT steel technologies applied in continuous rolling mills to produce various DHT steels for machining and cold forming applications.
Multilayered wideband absorbers for oblique angle of incidence (2010)

Design procedures of Jaumann and circuit analog absorbers are mostly formulated for normal angle of incidence. Only a few design methods considering oblique angle of incidence are published. The published methods are restricted to single resistive layer circuit analog absorbers or multilayered Jaumann absorbers with low permittivity spacers. General design procedures are developed in this paper for multilayered Jaumann and capacitive circuit absorbers. By expanding the scan and frequency compensation techniques to multilayered structures, Jaumann absorbers with outstanding performances are designed. A capacitive circuit absorber is presented with a stable frequency response up to 45 Degrees for both polarizations, having an ultra wide bandwidth of 26 GHz.
Multiple pathways of apolipoprotein E signaling in primary neurons (2005)

Apolipoprotein E is a genetic risk factor for Alzheimer's disease, and the apoE protein is associated with beta-amyloid deposits in Alzheimer's disease brain. We examined signaling pathways stimulated by apoE in primary neurons in culture. ApoE and an apoE-derived peptide activated several intracellular kinases, including prominently extracellular signal-regulated kinase 1/2 (ERK1/2). ERK1/2 activation by apoE was blocked by an inhibitor of the low-density lipoprotein receptor family, the specific NMDA glutamate receptor antagonist MK 801 and other calcium channel blockers. Activation of apoE receptors also induced tyrosine phosphorylation of Dab1, an adaptor protein of apoE receptors, but experiments in Dab1 knockout neurons demonstrated that Dab1 was not necessary for ERK activation. In contrast, apoE treatment of primary neurons decreased activation of c-Jun N-terminal kinase, a kinase that interacts with another apoE receptor adaptor protein, c-Jun N-terminal kinase-interacting protein. This change also depended on interactions with the low-density lipoprotein receptor family but was independent of calcium channels. c-Jun N-terminal kinase deactivation by apoE was blocked by gamma-secretase inhibitors and pertussis toxin. These results demonstrate that apoE affects several signaling cascades in neurons: increased disabled phosphorylation, activation of the ERK1/2 pathway (dependent on calcium influx via the NMDA receptor) and inhibition of the c-Jun N-terminal kinase 1/2 pathway (dependent on gamma-secretase and G proteins).
Critical PQ Interval for the Appearance of Diastolic Mitral Regurgitation and Optimal PQ Interval in Patients Implanted with DDD Pacemakers (1994)

Diastolic mitral regurgitation (MR) may be induced by prolonging atrioventricular (AV) delay, and a significant negative correlation has been described between the critical PQ interval for the appearance of diastolic MR and pulmonary capillary wedge pressure (PCWP) in patients with DDD pacemakers. We report the relationship between the critical PQ interval for the appearance of diastolic MR and the optimal PQ interval in 11 patients (69.1 +/- 12.6 years). Cardiac output (CO) and PCWP were measured by Swan-Ganz catheter and transmitral blood flow was recorded by pulsed-Doppler echocardiography. AV delay was prolonged stepwise by 0.025 seconds starting from 0.065 seconds. The pacing rate was fixed at 70 beats/min. CO was highest when the PQ interval was 0.18 +/- 0.04 seconds. There was a significant positive correlation between the critical PQ interval for the appearance of diastolic MR and the PQ interval at which CO was the highest (r = 0.91, P < 0.01). The PQ interval at which CO was the highest was 0.02 +/- 0.02 seconds shorter than the critical PQ interval for the appearance of diastolic MR (P < 0.05). When the PQ interval was increased by 0.025 seconds from the critical PQ interval for the appearance of diastolic MR, CO decreased from 4.3 +/- 0.6 L/min to 4.1 +/- 0.6 L/min and PCWP increased from 7.5 +/- 6.4 mmHg to 8.5 +/- 7.3 mmHg (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Software Defined Networks-Based Smart Grid Communication: A Comprehensive Survey (2019)

The current power grid is no longer a feasible solution due to ever-increasing user demand of electricity, old infrastructure, and reliability issues and thus require transformation to a better grid also known as, smart grid (SG). The key features that distinguish SG from the conventional electrical power grid are its capability to perform two-way communication, demand side management, and real time pricing. Despite all these advantages that SG will bring, there are certain issues which are specific to SG communication (SGC) system. For instance, network management of current SG systems is complex, time consuming, and done manually. Moreover, SGC system is built on different vendor specific devices and protocols. Therefore, the current SG systems are not protocol independent, thus leading to interoperability issue. Software defined network (SDN) has been proposed to monitor and manage the communication networks globally. By separating the control plane from the data plane, SDN helps the network operators to manage the network flexibly. Since SG heavily relies on communication networks, therefore, SDN has also paved its way into the SG. By applying SDN in SG systems, efficiency and resiliency can potentially be improved. SDN, with its programmability, protocol independence, and granularity features, can help the SG to integrate different SG standards and protocols, to cope with diverse communication systems, and to help SG to perform traffic flow orchestration and to meet specific SG quality of service requirements. This paper serves as a comprehensive survey on SDN-based SGC. In this paper, we first discuss taxonomy of advantages of SDN-based SGC. We then discuss SDN-based SGC architectures, along with case studies. This paper provides an in-depth discussion on routing schemes for SDN-based SGC. We also provide detailed survey of security and privacy schemes applied to SDN-based SGC. We furthermore present challenges, open issues, and future research directions related to SDN-based SGC.
Characterization of InGaN/AlGaN multiple-quantum-well laser diodes (1999)

This paper discusses the design and characteristics of III-nitride based multi-quantum well (MQW) laser diodes grown on a- as well as c-plane sapphire substrates by metal organic chemical vapor deposition (MOCVD). Threshold current densities as low as 4.8 kA/cm 2 have been observed on devices with CAIBE etched mirrors and a SiO 2 /TiO 2 high reflective coating on both facets. The lowest threshold currents obtained were around 55 mA (U th = 9.5V) for 3μm * 300μm ridge-waveguide laser diodes devices which allow room temperature pulsed operation up to 70% duty cycle (devices mounted p-side up). From cavity length studies the distributed loss in our structures was determined to be of the order of 35-45 cm -1 . At threshold this corresponds to a maximum modal gain of about 110 cm -1 or a material gain of about 2200 cm -1 .
Inter-Active-Site Distance and Solution Dynamics of a Bivalent-Bispecific Single-Chain Antibody Molecule (1994)

The solution dynamics of a bivalent bispecific single-chain antibody (BiSCA) specific against fluorescein (Fl) and single-stranded DNA (ssDNA) were investigated. Fluorescence resonance energy transfer (FRET) studies were performed in order to estimate the average distances, R, between the anti-Fl and the anti-ssDNA active sites. In separate experiments, either 2-(dimethylamino)naphthalene-5-sulfonyl chloride coupled to the 5' end of an oligothymidylate polymer of 6 residues length (2,5-DNS-dT6) served as energy donor to Fl or eosin isothiocyanate coupled to the 5' end of an oligothymidylate polymer of 6 residues length (eosin-dT6) served as energy acceptor from Fl. Labeling of dT6 with 2,5-DNS or eosin did not significantly interfere with recognition by the anti-ssDNA binding site. With the 2,5-DNS/Fl energy transfer pair, the calculated values of R(k2 = 2/3), R(min), and R(max) were 44, 37, and 54 A, respectively. With Fl/eosin (opposite direction of FRET), values of 40, 33, and 51 A, respectively, were obtained. Considering the sizes of the two SCA domains and the length of the interdomain polypeptide linker, an R value of approximately 140 A would be expected for the extended molecule. The fact that measured R distances were on average 3-fold shorter than 140 A indicated that BiSCA was not an extended and rigid molecule. The efficiency of energy transfer increased with increasing temperature in the range of 10-30 degrees C, suggesting that conformational fluctuations of the protein resulted in decreased average distance between BiSCA active sites.(ABSTRACT TRUNCATED AT 250 WORDS)
Hydrodynamic characteristics of the thin fluid film in chemical-mechanical polishing (2002)

Presents results of an analytical study involving the kinematics and pressure distribution developed in the wafer-pad interface during a chemical-mechanical polishing (CMP) process. The mathematical modeling of the kinematics and dynamics of the interface is simplified by the use of the circumferential average technique yielding equations that are readily solved. The analytical results are in reasonably good agreement with those reported by previous authors using the direct numerical simulation of the Navier-Stokes equations. Furthermore, the present analysis clearly demonstrates the physical significance in the CMP process contributed by a variety of the operating parameters including rotation speed, offset of rotational axis, wafer curvature, slurry viscosity, and thickness of fluid film between the wafer and pad.
The development and character of the research of prehistoric cave sites in Gangwon Province (2019)

강원도에서 지금까지 체계적으로 발굴 조사된 선사시대의 동굴유적은 모두 6곳이며 이들은 모두 2000년대 이후에 조사 연구가 시작되었다. 유적은 구석기시대의 동굴 2 곳(쌍굴, 연이굴), 신석기시대의 동굴 2 곳(공기2굴, 꽃 병굴) 그리고 구석기시대부터 신석기⋅청동기시대까지 계속되는 동굴 2 곳 (피난굴, 매둔굴)으로 이루어진다. 이들 각 유적들의 위치, 크기, 특징, 경관 고고학(Tophography)상의 해석을 통해 전체적인 강원도 지역의 동굴유적의 특징을 고찰하여 보았다. 유적들은 일반으로 해발고도가 200m 이상 되는 곳에 위치하고 있으며 특히 연이굴은 740m의 높이에 자리한다. 굴의 규모는 대체로 작은 편이며 이 가운데 매둔동굴이 다소 큰 편이다. 출토유물의 많은 비율은 동물화석이지만 석기들도 확인되고 있으며 전체적의 총발견 유물의 량은 적은 편이다. 이러한 강원도 지역의 동굴유적들은 대체로 후기 갱신세의 늦은 시기 (MIS 3,2기) 또는 현세(MIS1기)에 점유된 유적들이 대부분이다. 각 유적들의 연대측정 자료뿐만 아니라 이 지역에서 출토된 동물들의 양상이 이를 뒷받 침하여주고 있다. 이것은 이지역에서의 사람들의 점유가 구석기시대의 늦은 시기이후에 이루어졌음을 보여주는 것으로 역시 지형학적인 입지조건과 많은 연관이 있음을 알 수 있었다. 아직도 강원도의 석회암지대에는 조사되지 않은 동굴들이 많다. 그러므로 앞으로 이 강원도 지역에서 종합적이고 체계적인 동굴유적의 연구와 고고학적 분석이 이루어지기를 기대한다. 이러한 작업이 이루어질 때 더욱 이 지역의 선사시대의 동굴유적의 특징과 성격이 명확하게 드러날 것이다.There are six prehistoric cave sites in Gangwon Province that have been systematically excavated, all of which began to be excavated after the 2000s. The Cave sites include two caves in the Paleolithic period (Ssanggul, Yeon-igul), two caves in the Neolithic period (Gonggi2gul, Kkotbyeonggul) and two caves (Pinangul, Maedungul) from the Paleolithic to Bronze Age. The location, size, and topography interpretations of each of these sites were used to examine the overall characteristics of the cave sites in Gangwon Province. The sites are generally located at an altitude of more than 200 meters above sea level, especially at a height of 740 meters at Yeon-igul. The scales of cave are generally small, and the Maedungul, among them, is rather large. Most of excavated remains are animal fossils and a small number of stone tools are also identified. Most of these cave sites in Gangwon Province are largely occupied in the late period of the Pleistocene (MIS 3,2 period) or the Holocene (MIS 1 period). This is supported by not only dating data of each cave, but also compositions of animals excavated in this area. This shows that the occupation of people in this area took place after the late period of the Paleolithic period, and it was also found to be highly related to geographical location conditions. There are still many unexcavated caves in the limestone areas of Gangwon Province. Therefore, it needs the comprehensive and systematic excavations of these cave sites and archeological analysis will be conducted in the future. When this work is done, the character of the prehistoric cave sites of this area will become clear.
Protein kinase C and its substrates in tumor promoter-sensitive and -resistant cells. (1988)

Calcium- and phospholipid-dependent protein kinase C activity and substrates were characterized in cell lysates of preneoplastic JB6 cells, a model system of genetic variants for sensitivity to tumor promoter-induced neoplastic transformation. Protein kinase C activity was similar for sensitive and resistant variants, as measured by calcium- and phospholipid-dependent phosphorylation of an exogenous substrate (histone HIII). Of 13 endogenous protein kinase C substrates, identified by labeling proteins with [gamma-32P] ATP, at least two (80 and 23 kDa) are potential candidates for mediating events on the pathway for promotion of transformation. 32P incorporation into the 80-kDa protein kinase C substrate was stimulated by tetradecanoylphorbol acetate and correlated with phenotype: the highest incorporation was found in promotion-insensitive cells, an intermediate level in promotion-sensitive cells and the lowest in the transformed cells. The phosphorylation of an 80-kDa protein, found by labeling intact cells in monolayer growth with [32P]orthophosphate, was also stimulated by tetradecanoylphorbol acetate and correlated inversely with phenotype. The 80 kDa protein kinase C substrate from cell lysates and the 80-kDa phosphoprotein from intact cells appear to be identical, as indicated by peptide mapping with protease V8 from Staphylococcus aureus. This finding suggests that the 80-kDa substrate is relevant to promoter-induced signal transduction in the intact cell. The 23-kDa protein kinase C substrate exhibited a band shift in sodium dodecyl sulfate gels in response to another transformation promoter in JB6 cells, the calcium analog, lanthanum (Smith, B. M., Gindhart, T. D., and Colburn, N. H. (1986) Carcinogenesis 7, 1949-1956). In summary, there are no unique substrates that distinguish the variants. Quantitative differences in certain substrates or their phosphorylation may, however, account for the difference in promotion sensitivity among the variants.
Neurofeedback 2.0? (2011)

Our field is developing rapidly without many of us being fully aware of the fundamental progress taking place at the time of writing. In 1999 the web was developing at a fast pace and becoming wide...
Ambiguous Role of Interleukin-12 in<i>Yersinia enterocolitica</i>Infection in Susceptible and Resistant Mouse Strains (1998)

Endogenous interleukin-12 (IL-12) mediates protection against Yersinia enterocolitica in C57BL/6 mice by triggering gamma interferon (IFN-gamma) production in NK and CD4+ T cells. Administration of exogenous IL-12 confers protection against yersiniae in Yersinia-susceptible BALB/c mice but exacerbates yersiniosis in resistant C57BL/6 mice. Therefore, we wanted to dissect the different mechanisms exerted by IL-12 during Yersinia infections by using different models of Yersinia-resistant and -susceptible mice, including resistant C57BL/6 mice, susceptible BALB/c mice, intermediate-susceptible wild-type 129/Sv mice, 129/Sv IFN-gamma-receptor-deficient (IFN-gamma R-/-) mice and C57BL/6 tumor necrosis factor (TNF) receptor p55 chain-deficient (TNFR p55-/-) mice. IFN-gamma R-/- mice turned out to be highly susceptible to infection by Y. enterocolitica compared with IFN-gamma R+/+ mice. Administration of IL-12 was protective in IFN-gamma R+/+ mice but not in IFN-gamma R-/- mice, suggesting that IFN-gamma R-induced mechanisms are essential for IL-12-induced resistance against yersiniae. BALB/c mice could be rendered Yersinia resistant by administration of anti-CD4 antibodies or by administration of IL-12. In contrast, C57BL/6 mice could be rendered more resistant by administration of transforming growth factor beta (TGF-beta). Furthermore, IL-12-triggered toxic effects in C57BL/6 mice were abrogated by coadministration of TGF-beta. While administration of IL-12 alone increased TNF-alpha levels, administration of TGF-beta or TGF-beta plus IL-12 decreased both TNF-alpha and IFN-gamma levels in Yersinia-infected C57BL/6 mice. Moreover, IL-12 did not induce toxicity in Yersinia-infected TNFR p55-/- mice, suggesting that TNF-alpha accounts for IL-12-induced toxicity. Taken together, IL-12 may induce different effector mechanisms in BALB/c and C57BL/6 mice resulting either in protection or exacerbation. These results are important for understanding the critical balance of proinflammatory and regulatory cytokines in bacterial infections which is decisive for beneficial effects of cytokine therapy.
Sound source localization and signal separation for office robot "JiJo-2" (2003)

A method of sound source localization and source separation for the sound sources in the near-field range is described in this paper. For the sound localization, the subspace method was employed to obtain a high resolution which is necessary for the range estimation with a small-sized array. The modified MVBF with the estimated localization information was used for signal separation. In an experiment conducted in a middle-sized meeting room, 60-70% of word recognition rate was achieved.
Three-Dimensional Nanoscale Organization of Bulk Heterojunction Polymer Solar Cells (2008)

In this study, the three-dimensional (3D) nanoscale organization in the photoactive layers of poly(3-hexylthiophene) (P3HT) and a methanofullerene derivative (PCBM) is revealed by electron tomography. Morphologies suggested by previous experimental evidence were, for the first time, observed directly with a nanometer resolution and studied in detail. After annealing treatment, either at elevated temperature or during slow solvent evaporation, genuine 3D nanoscale networks are formed with high crystalline order and favorable concentration gradients of both P3HT and PCBM through the thickness of the photoactive layer. These favorable morphological changes account for a considerable increase of the power conversion efficiency in corresponding solar cell devices.