gebhart/patrepeval huggingface dataset:
The Thinning Zhang-Suen Application Method in the Image of Balinese Scripts on the Papyrus (2014)

One of the cultural heritage which are now starting to be forgotten is the papyrus library. Balinese papyrus is one of the media to write the ideas from minstrels in ancient times. Currently, many of ancient literature that written in papyrus very difficult to identify because the writings were beginning to rot or fade influenced by age. The introduction of Balinese scripts on papyrus can be done first by performing papyrus digitalization. The papyruses are scanned to become one image file. Further the papyrus image is done by Thresholding since prior to the thinning process it is required a binary image. The application of Thinning Zhang-Suen method is very effective because from the original image with 2 sub iteration until yielding in 1 pixel. The benefits of this research is to improve the quality of the image and further segmented to read papyrus making it easier to read text on the papyrus.
Inhibition of Poly(ADP-Ribose) Polymerase Modulates Tumor-Related Gene Expression, Including Hypoxia-Inducible Factor-1 Activation, during Skin Carcinogenesis (2006)

Poly(ADP-ribose) polymerase (PARP)-1, an enzyme that catalyzes the attachment of ADP ribose to target proteins, acts as a component of enhancer/promoter regulatory complexes. In the present study, we show that pharmacologic inhibition of PARP-1 with 3,4-dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) results in a strong delay in tumor formation and in a dramatic reduction in tumor size and multiplicity during 7,12-dimethylbenz(a)anthracene plus 12-O-tetradecanoylphorbol-13-acetate-induced skin carcinogenesis. This observation was parallel with a reduction in the skin inflammatory infiltrate in DPQ-treated mice and tumor vasculogenesis. Inhibition of PARP also affected activator protein-1 (AP-1) activation but not nuclear factor-kappaB (NF-kappaB). Using cDNA expression array analysis, a substantial difference in key tumor-related gene expression was found between chemically induced mice treated or not with PARP inhibitor and also between wild-type and parp-1 knockout mice. Most important differences were found in gene expression for Nfkbiz, S100a9, Hif-1alpha, and other genes involved in carcinogenesis and inflammation. These results were corroborated by real-time PCR. Moreover, the transcriptional activity of hypoxia-inducible factor-1alpha (HIF-1alpha) was compromised by PARP inhibition or in PARP-1-deficient cells, as measured by gene reporter assays and the expression of key target genes for HIF-1alpha. Tumor vasculature was also strongly inhibited in PARP-1-deficient mice and by DPQ. In summary, this study shows that inhibition of PARP on itself is able to control tumor growth, and PARP inhibition or genetic deletion of PARP-1 prevents from tumor promotion through their ability to cooperate with the activation AP-1, NF-kappaB, and HIF-1alpha.
Adenovirus-mediated Transfer of CCAAT/Enhancer-binding Protein-α Identifies a Dominant Antiproliferative Role for This Isoform in Hepatocytes (1996)

CCAAT/enhancer-binding protein (C/EBP) isoforms are thought to be important regulators of the hepatocyte phenotype. However, the specific physiological roles of different isoforms are poorly understood because hepatocytes express multiple C/EBPs, and various isoforms have overlapping functions. To identify the functions of C/EBPalpha in mature hepatocytes, replication-defective adenovirus vectors were used to efficiently and homogeneously overexpress the mouse C/EBPalpha gene in a SV40 virus-conditionally transformed rat hepatocyte line that can be induced to express C/EBPbeta and C/EBPdelta but that has little endogenous C/EBPalpha expression. Hepatocytes were infected with a recombinant adenovirus vector carrying the cDNA for C/EBPalpha driven by Rous sarcoma virus promoter elements (AdCEBPalpha) or a similar vector carrying the Escherichia coli lacZ gene (Adbetagal). Staining for beta-galactosidase demonstrated an infection efficiency of 100% at a multiplicity of infection of 25 plaque-forming units/cell and persistence of foreign gene expression for at least 9 days. Cultures infected with AdCEBPalpha had 50-fold higher levels of C/EBPalpha mRNA and protein than those infected with Ad-beta-gal, but similar expression of C/EBP-beta. Infection with AdCEBPalpha inhibited proliferation in cells expressing little C/EBPbeta, even when proliferation was driven by the SV40 transforming antigen, and also blunted mitogenic induction of the c-myc proto-oncogene in nontransformed cells with high levels of C/EBPbeta. Although overexpression of C/EBPalpha consistently increased C/EBPalpha DNA binding activity, it was not sufficient for albumin expression. Infection with AdCEBPalpha only increased albumin mRNA levels in nontransformed cells that also expressed relatively high levels of C/EBPbeta. Thus, in hepatocytes, C/EBPalpha has a dominant antiproliferative function, but must interact with other factors to regulate hepatocyte-specific gene expression.
信息是现象,是功能,还是假象? (1991)

60—70年代对信息问题进行的热烈讨论,当然不是徒劳无益的。关于信息与反映、信息与控制的相互联系的原理得到了确认;信息即使没有获得哲学范畴的地位,起码也获得了一般科学范畴的地位。但不管怎么说,还是留下了许多晦暗不明的东西。40年前Н·维纳的否定性说明“信息就是信息,而不是物质,也不是能量”,至今仍是不易之论。在我们的哲学科学中,两种最具权威性的(但远非绝无仅有的)观点即属性观和功能观,15年来一直相互对立着。两种观点都断言,信息存在于客观现实之中,但在非生物界中是否存在信息的问题上
Calcium Hexaluminate and Its Stability Relations in the System CaO–Al <sub>2</sub> O <sub>3</sub> –SiO <sub>2</sub> (1963)

By a combination of solid‐state sintering and quenching experiments the validity of calcium hexaluminate as a stable phase and the extent of its primary field in the system CaO–Al 2 O 3 –SiO 2 have been established. The size of the primary field is considerably reduced from that suggested by earlier work. The anorthite‐corundum‐calcium hexaluminate invariant point has been relocated at 28.0% CaO, 39.7% Al 2 O 2 , and 32.3% SiO 2 and at 1405°± 5°C.
Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy — Brazil, 2015 (2016)

Widespread transmission of Zika virus by Aedes mosquitoes has been recognized in Brazil since late 2014, and in October 2015, an increase in the number of reported cases of microcephaly was reported to the Brazil Ministry of Health.* By January 2016, a total of 3,530 suspected microcephaly cases had been reported, many of which occurred in infants born to women who lived in or had visited areas where Zika virus transmission was occurring. Microcephaly surveillance was enhanced in late 2015 by implementing a more sensitive case definition. Based on the peak number of reported cases of microcephaly, and assuming an average estimated pregnancy duration of 38 weeks in Brazil (1), the first trimester of pregnancy coincided with reports of cases of febrile rash illness compatible with Zika virus disease in pregnant women in Bahia, Paraíba, and Pernambuco states, supporting an association between Zika virus infection during early pregnancy and the occurrence of microcephaly. Pregnant women in areas where Zika virus transmission is occurring should take steps to avoid mosquito bites. Additional studies are needed to further elucidate the relationship between Zika virus infection in pregnancy and microcephaly.
Material reaction and silicide formation at the refractory metal/silicon interface (1986)

Medium energy ion scattering studies show that material reactions other than interfacial silicide formation dominate the low-temperature reactivity of the Ti/Si interface. This provides an explanation for the anomalous kinetics and considerable extent (100 Å or more) of reaction of refractory metals with Si, which are observed well below the temperatures normally associated with silicide growth in thicker films.
Brewers' spent grain: a review with an emphasis on food and health (2016)

Brewers' spent grain (BSG) is the most abundant by-product generated in the beer-brewing process. This material consists of the barley grain husks obtained as solid residue after the production of wort. BSG is rich in fibre and protein and, to date, the main use for the elimination of this by-product has been as an animal feed. However, because of its nutritional content, BSG is of interest for application and fortification of human food products, particularly in view of its low cost and availability in large amounts. In addition, the importance of BSG as an ingredient and potential source of health-promoting bioactive components is beginning to be recognised. The investigation of alternative uses of BSG is pertinent, not only from the perspective of the brewer who can benefit from valorisation of this by-product, but also from an environmental perspective as the recycling and re-use of industrial wastes and by-products has become increasingly important. This review presents the current knowledge on BSG, covering its production, composition and methods for the release of valuable components, and focuses on the potential health benefits attributed to its constituents and the use of this brewer by-product in food applications.
The immunogenicity and safety of an investigational meningococcal serogroups A, C, W-135 and Y tetanus toxoid conjugate vaccine (ACWY-TT) compared with a licensed meningococcal tetravalent polysaccharide vaccine (2012)

Immunogenicity and safety of ACWY-TT compared with licensed ACWY polysaccharide vaccine (MenPS) in healthy adults, and lot-to-lot consistency of three ACWY-TT lots were evaluated in a phase 3, open, controlled study. Adults aged 18-55 y were randomized to receive ACWY-TT (one of three lots) or MenPS. Serum bactericidal antibodies (rSBA) were measured pre- and 1 mo post-vaccination. Adverse events (AEs) were assessed 4 d (solicited symptoms) and 31 d (unsolicited symptoms) post-vaccination. Serious AEs were reported up to 6 mo after vaccination. The number of vaccinated subjects was 1247 (ACWY-TT, n = 935; MenPS, n = 312). ACWY-TT lot-to-lot consistency and non-inferiority of ACWY-TT as compared with MenPS groups were demonstrated according to pre-specified criteria. The percentages of subjects with a vaccine response (VR = rSBA titer ≥ 1:32 in initially seronegative; ≥ 4-fold increase in initially seropositive) to ACWY-TT vs. MenPS were 80.1%/69.8% (serogroup A), 91.5%/ 92.0% (C), 90.2%/85.5% (W-135), 87.0%/78.8% (Y). Exploratory analyses showed that for serogroups A, W-135 and Y, VR rates and GMTs were significantly higher for ACWY-TT compared with MenPS. For each serogroup, ≥ 98.0% of subjects had rSBA titers ≥ 1:128. Grade 3 solicited AEs were reported in ≤ 1.6% of subjects in any group. The immunogenicity of ACWY-TT vaccine was non-inferior to MenPS for all four serogroups in adults, with significantly higher VR rates to serogroups A, W-135 and Y and an acceptable safety profile. Consistency of 3 ACWY-TT production lots was demonstrated. These data suggest that, if licensed, ACWY-TT conjugate vaccine may be used for protection against invasive meningococcal disease in healthy adults. This study is registered at clinicaltrials.gov NCT00453986.
A quantum network with atoms and photons (QNET-AP) (2012)

Enabling secure communication, unparalleled computing capabilities, and fundamental nonlocality physics exploration, the development of quantum repeaters is the key quantum information processing technology advance needed for implementing real world quantum networks beyond the laboratory environment. Currently, components exist for intra-laboratory quantum networks but no system exists for connecting distant ( 1 km ) quantum memories in the real world. We present a physics analysis of quantum repeater network designs for intracity optical fiber connections between nodes based on atomic memories and linear optics. Long distances will necessitate the use of (1) two-photon Hong-Ou-Mandel style interference between atomic ensembles for entanglement swapping, and (2) photonic qubit wavelength conversion between atomic emissions and photons at telecommunication wavelengths in fiber. We report on our experimental progress towards implementing A Quantum Network with Atoms and Photons (QNET-AP), a quantum repeater network test-bed, between the US Army Research Laboratory (ARL) and the Joint Quantum Institute (JQI) of the National Institute of Standards and Technology (NIST) and the University of Maryland (UMD).
Plasmonic Conducting Metal Oxide-Based Optical Fiber Sensors for Chemical and Intermediate Temperature-Sensing Applications (2018)

The demand for real-time sensors in harsh environments at elevated temperature is significant and increasing. In this manuscript, the chemical and temperature sensing using the optical response through the practical fiber platform is demonstrated, and principle component analysis is coupled with targeted experimental film characterization to understand the fundamental sensing layer properties, which dominate measured gas sensing responses in complex gas mixtures. More specifically, tin-doped indium oxide-decorated sensors fabricated with the sol-gel method show stable and stepwise transmission responses varying over a wide range of H<sub>2</sub> concentration (5-100%) at 250-350 °C as well as responses to CH<sub>4</sub> and CO to a lesser extent. Measured responses are attributed to modifications to the surface plasmon resonance absorption in the near-infrared range and are dominated by the highest concentrations of the most-reducing analyte based upon systematic mixed gas stream experiments. Principal component analysis is utilized for this type of sensor to improve the quantitative and qualitative understanding of responses, clearly identifying that the dominant principle component (PC #1) accounts for ∼78% of total data variance. Correlations between PC #1 and the experimentally derived free carrier concentration confirm that this material property plays the strongest role on the ITO gas sensing mechanism, while correlations between the free carrier mobility and the second most important principle component (PC #2) suggest that this quantity may play a significant but secondary role. As such, the results presented here clarify the relationship between generalized principle components and fundamental sensing materials properties thereby suggesting the pathway toward improved multicomponent gas speciation through sensor layer engineering. The work presented represents a significant step toward the ultimate objective of optical waveguide sensors integrated with multivariate data analytics for multiparameter monitoring with a single sensor element.
Collaborative reputation mechanisms for online communities (1999)

Thesis (S.M.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 1999.
Robust Tracking of Multiple People in Crowds Using Laser Range Scanners (2006)

Laser based people tracking systems have been developed for mobile robotic or intelligent surveillance areas. Existing systems rely on laser point clustering to extract object locations. However, in a crowded environment, laser points of different objects are often interlaced and undistinguishable and can not provide reliable features. This paper presents a novel and robust laser-based tracking method for people in crowds. Firstly, we propose a stable feature extraction method based on accumulated distribution of successive laser frames. Then a robust tracking filter is proposed based on the combination of independent Bayesian filter and sampling based data association filter. Evaluations with real data show that the proposed method is robust and effective. It achieves a significant improvement compared with existing trackers
High Performance Silicon Imaging : Fundamentals and Applications of CMOS and CCD sensors (2014)

High Performance Silicon Imaging covers the fundamentals of silicon image sensors, with a focus on existing performance issues and potential solutions. The book considers several applications for the technology as well. Silicon imaging is a fast growing area of the semiconductor industry. Its use in cell phone cameras is already well established, and emerging applications include web, security, automotive, and digital cinema cameras. Part one begins with a review of the fundamental principles of photosensing and the operational principles of silicon image sensors. It then focuses in on charged coupled device (CCD) image sensors and complementary metal oxide semiconductor (CMOS) image sensors. The performance issues considered include image quality, sensitivity, data transfer rate, system level integration, rate of power consumption, and the potential for 3D imaging. Part two then discusses how CMOS technology can be used in a range of areas, including in mobile devices, image sensors for automotive applications, sensors for several forms of scientific imaging, and sensors for medical applications. High Performance Silicon Imaging is an excellent resource for both academics and engineers working in the optics, photonics, semiconductor, and electronics industries.Covers the fundamentals of silicon-based image sensors and technical advances, focusing on performance issuesLooks at image sensors in applications such as mobile phones, scientific imaging, TV broadcasting, automotive, and biomedical applications
Combined Effects of Laser Irradiation and Chemical Inhibitors on the Dissolution of Dental Enamel (1992)

It has previously been shown that the susceptibility of human teeth to acid dissolution can be reduced by the presence of various chemical agents in the dissolution medium or by pretreatment of the teeth with laser irradiation. Now synergism between these two approaches to improving acid resistance has been demonstrated. Extracted human teeth were irradiated with a continuous-wave carbon dioxide laser at a wavelength of 10.6 microns. Energy doses of either 65 or 130 J/cm2 given over periods of 2 or 4 s, respectively, were applied and the teeth subjected to a severe acid challenge (0.1 M acetate buffer, pH 4.5, no calcium or phosphate common ion present) for 24 h. Mineral loss was assessed by measurement of mineral density profiles with quantitative microradiography. Experiments were carried out in the presence or absence of three chemical inhibitors with distinctly different mechanisms of action: ethane-1-hydroxy-1, 1-diphosphonic acid, fluoride, and dodecylamine HCl. Laser irradiation alone was found to lead to increased resistance of the teeth to acid challenge, with the higher energy dose being more effective than the lower dose. Each of the chemical inhibitors was effective on both lased and unlased teeth, with the percent reduction of dissolution greater when the inhibitors were applied to teeth lased with an energy dose of 130 J/cm2 which were already more resistant to acid challenge than were unlased teeth or teeth lased with a dose of 65 J/cm2.(ABSTRACT TRUNCATED AT 250 WORDS)
Design and development of a low cost inverter drive for induction motors (2002)

The growth in high volume market in variable speed drives is expected due to emerging applications in home appliances, HVAC drives, professional hand tools, automobile accessories, fans, pumps, and process drives. The inverter controlled induction motor drive is a strong competitor for such applications due to the low cost of the motor and to its inherent features such as the simplicity of control requiring no sensors in these low performance applications, brushless as it has no slip rings thus making it truly almost maintenance-free, robust and proven construction and operation. Most of the drive's cost comes from the inverter and its controller. These low performance applications require less than or equal to $35 per hp in the cost of the inverter and its controller. The requirement is that the packaging be the smallest possible compared to the currently available in the market place and should be within 100 cubic inches including the enclosure. This paper addresses issues of design and development of such a low cost inverter and its controller to obtain one hp variable speed induction motor drives. The various issues addressed in detail are: specifications, appropriate control strategy and drive configuration, design of control circuits, their layout in printed circuit boards, layout of power circuit, switching and conduction losses and development of compact cooling arrangement tuning, ease of manufacturability and packaging. Results from a fully packaged one horsepower experimental inverter controlled induction motor drive system are presented.
New Interface for Rapid Feedback Control on ABB-Robots (2005)

Automation in manufacturing has come far by using industrial robots. However, industrial robots require tremendous efforts in static calibration due to their lack of senses. Force and vision are the most useful sensing capabilities for a robot system operating in an unknown or uncalibrated environment [4]and by integrating sensors in real-time with industrial robot controllers, dynamic processes need far less calibration which leads to reduced lead time. By using robot systems which are more dynamic and can perform complex tasks with simple instructions, the production efficiency will rise and hence also the profit for companies using them. Although much research has been presented within the research community, current industrial robot systems have very limited support for external sensor feedback, and the state-of-the-art robots today have generally no feedback loop that can handle external force- or position controlled feedback. Where it exists, feedback at the rate of 10 Hz is considered to berare and is far from real-time control. A new system where the feedback control can be possible within a real-time behavior, developed at Lund Institute of Technology, has been implemented and deployed at Linköping Institute of Technology. The new system for rapid feedback control is a highly complex system, possible to install in existing robot cells, and enables real-time (250 Hz) sensor feedback to the robot controller. However, the system is not yet fully developed, and a lot of issues need to be considered before it can reach the market in other than specific applications. The implementation and deployment of the new interface at LiTH shows that the potential for this system is large, since it makes production with robots exceedingly flexible and dynamic, and the fact that the system works with real- time feedback makes industrial robots more useful in tasks for manufacturing.
Synthesis of PLA-b-PEG Multiblock Copolymers for Stealth Drug Carrier Preparation (2005)

An efficient method of preparing biodegradable and biocompatible multiblock copolymers from lactic acid and polyethylene glycol is proposed.
THE PREPARATION OF 4,6-<i>O</i>-BENZYLIDENE-<scp>D</scp>-GLUCAL AND THE REACTION OF METHYLLITHIUM WITH METHYL 2,3-ANHYDRO-4,6-<i>O</i>-BENZYLIDENE-α-<scp>D</scp>-ALLOPYRANOSIDE (1966)

4,6-O-Benzylidene-D-glucal has been prepared by the reaction of benzaldehyde with D-glucal. The reaction of commercial methyllithium with methyl 2,3-anhydro-4,6-O-benzylidene-α-D-allopyranoside produces the C 2 -methylated 1,2-unsaturated compound 4,6-O-benzylidene-1,2-didehydro-1,2-dideoxy-2-methyl-D-ribo-hexopyranose. Their structures have been proven by first-order analyses of their nuclear magnetic resonance spectra.