gebhart/patrepeval huggingface dataset:
Low Power and Low Noise Shift Register for In-Cell Touch Display Applications (2018)

This paper proposes a shift register circuit integrated in in-cell touch display panels that achieves low power operation, low coupling noise, and high long-term reliability with 11 thin film transistors (TFTs) and two capacitors. A time division driving method is utilized to prevent the crosstalk of display signals into touch circuits, and two pre-charging nodes are employed to relieve the uniformity degradation of output signals caused by different stresses on pull-up TFTs. The proposed circuit activates a drain of the first pre-charging TFT only at display scanning periods, which reduces coupling noises and power consumption. In addition, an internal inverter is turned off for touch sensing operations, resulting in a wide range of threshold voltage shift compensation and low power consumption. SPICE simulation results with a low temperature poly silicon TFT model show that the proposed circuit compensates for the threshold voltage shift up to 17 V. In a 60 Hz full-HD display with a 120 Hz touch reporting rate, the noise level of the first pre-charging node is -16.78 dB in between 2.37 and -28.95 dB of two previous circuits, and the total power consumption for 160 stages is substantially reduced to 4.44 mW compared to previous approaches.
Digital Predistorter Design Using B-Spline Neural Network and Inverse of De Boor Algorithm (2013)

This contribution introduces a new digital predistorter to compensate serious distortions caused by memory high power amplifiers (HPAs) which exhibit output saturation characteristics. The proposed design is based on direct learning using a data-driven B-spline Wiener system modeling approach. The nonlinear HPA with memory is first identified based on the B-spline neural network model using the Gauss-Newton algorithm, which incorporates the efficient De Boor algorithm with both B-spline curve and first derivative recursions. The estimated Wiener HPA model is then used to design the Hammerstein predistorter. In particular, the inverse of the amplitude distortion of the HPA's static nonlinearity can be calculated effectively using the Newton-Raphson formula based on the inverse of De Boor algorithm. A major advantage of this approach is that both the Wiener HPA identification and the Hammerstein predistorter inverse can be achieved very efficiently and accurately. Simulation results obtained are presented to demonstrate the effectiveness of this novel digital predistorter design.
OaSys: FTR&D UMTS automatic cell planning tool (2003)

An efficient automatic cell-planning (ACP) tool for UMTS mobile networks, OaSys, is presented in this paper. The ACP is orchestrated by a genetic algorithm (GA) that adjusts antenna parameters and common channel transmitted powers to optimize the network performance such as coverage, capacity and cost. An example of network optimization illustrates the effectiveness of OaSys ACP.
An Analysis of the Influence of Plant Density on the Growth of<i>Vicia faba</i> (1957)

Journal Article An Analysis of the Influence of Plant Density on the Growth of Vicia faba: II. THE SIGNIFICANCE OF COMPETITION FOR LIGHT IN RELATION TO PLANT DEVELOPMENT AT DIFFERENT DENSITIES Get access G. L. HODGSON, G. L. HODGSON Department of Agriculture, University of Oxford Search for other works by this author on: Oxford Academic PubMed Google Scholar G. E. BLACKMAN G. E. BLACKMAN Department of Agriculture, University of Oxford Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Experimental Botany, Volume 8, Issue 2, 1957, Pages 195–219, https://doi.org/10.1093/jxb/8.2.195 Published: 01 July 1957 Article history Received: 20 August 1956 Published: 01 July 1957
Optimal radiolabeled liposomes for tumor imaging. (1996)

For tumor imaging with radiolabeled liposomes, we should choose liposomal formulations and dose to give prolonged blood retention for large tumor delivery. We must then select liposomes that give good tumor-to-blood values. For the best results, the radionuclide should have intrinsic tumor affinity. Labeled liposomes that meet these criteria result in excellent tumor images.
The “Bridging” Aspartate 178 in Phthalate Dioxygenase Facilitates Interactions between the Rieske Center and the Iron(II)−Mononuclear Center (2006)

Phthalate dioxygenase (PDO) and its reductase are parts of a two-component Rieske dioxygenase system that initiates the aerobic breakdown of phthalate by forming cis-4,5-dihydro-4,5-dihydroxyphthalate (DHD). Aspartate D178 in PDO, located near its ferrous mononuclear center, is highly conserved among Rieske dioxygenases. The analogous aspartate has been implicated in electron transfer between the mononuclear iron and Rieske center in naphthalene dioxygenase [Parales et al. (1999) J. Bacteriol. 181, 1831-1837] and in substrate binding and oxygen reactivity in anthranilate dioxygenase [Beharry et al. (2003) Biochemistry 42, 13625-13636]. The effects of substituting D178 in PDO with alanine or asparagine on the reactivity of the Rieske centers, phthalate hydroxylation, and coupling of Rieske center oxidation to DHD formation were studied previously [Pinto et al. (2006) Biochemistry 45, 9032-9041]. This work describes effects that D178N and D178A substitutions have on the interactions between the Rieske and mononuclear centers in PDO. The mutations affected protonation of the Rieske center histidine and conformation of subunits within the PDO multimer to create a more open structure with more solvent-accessible Rieske centers. When the Rieske centers in PDO were oxidized, D178N and D178A substitutions disrupted communication between the Rieske and Fe-mononuclear centers. This was shown by the lack of perturbations of the UV-vis spectra on phthalate binding to the D178N and D178A variants, as opposed to that observed in WT PDO. However, when the Rieske center was in the reduced state, communication between the centers was not disrupted. Phthalate binding similarly affected the rates of oxidation of the reduced Rieske center in both WT and mutant PDO. Nitric oxide binding at the Fe(II)-mononuclear center, as detected by EPR spectrometry of the Fe(II) nitrosyl complex, was regulated by the redox state of the Rieske center. When the Rieske center was oxidized in either WT or D178N PDO, NO bound to the mononuclear iron in the presence or absence of phthalate. However, when the Rieske center was reduced, NO bound only when phthalate was present. These findings are discussed in terms of the "communication functions" performed by the bridging Asp-178.
Thulium doped terbium sensitised CW fluoride fibre laser operating on the 1.47 μm transition (1993)

Results are presented, for the first time, regarding the spectroscopy and the laser performance of a fluorozirconate fibre codoped with thulium and terbium (0.1% : 1%). This doping scheme relies on concentration induced cross-relaxation effects to relieve population bottlenecked in Tm 3H4 to Tb 7F0. A minimum threshold of 5.5 mW and a maximum slope efficiency of 16% with respect to launched pump power has been observed for operation on the 1.47 μm transition.
Highly efficient whole‐heart imaging using radial phase encoding‐phase ordering with automatic window selection (2011)

Three dimensional (3D) whole-heart magnetic resonance imaging (MRI) has become an important imaging modality to assess cardiovascular diseases. The main challenges for 3D whole-heart MRI are long acquisition times, required to achieve high spatial resolution, and image artefacts due to physiological motion. Here we propose to overcome these problems by the combination of an interleaved Radial Phase Encoding trajectory and the Phase Ordering with Automatic Window Selection method. This Radial Phase Encoding-Phase Ordering with Automatic Window Selection approach yields fast 3D whole-heart imaging with a high isotropic resolution and high navigator efficiency even for extremely irregular breathing. Numerical simulations were performed and Radial Phase Encoding-Phase Ordering with Automatic Window Selection was implemented on a clinical scanner. A comparison between the proposed method and a respiratory gated 3D Cartesian approach was carried out. Radial Phase Encoding-Phase Ordering with Automatic Window Selection leads to a better depiction of coronary arteries and an increase in navigator efficiency. In addition to a high resolution image, this method also provides dynamic respiratory information without an increase in scan time.
Neighborhood Environment Walkability Scale (2006)

The NEWS and NEWS-A possess adequate levels of factorial and criterion validity. Alternative methods of scoring for different purposes are presented.
Adding the EPSG:4326 Geographic Longitude-Latitude Projection to TerraServer (2003)

This report describes the addition of EPSG:4326 Geographic longitude-latitude projection to the Open GIS Consortium Web Map Server (OGCWMS) component of TerraServer. The key effort involved experimenting with two algorithms for achieving the re-projection: (a) apply an affine or affine-perspective transformation to the UTM imagery so that resulting image looks geographically projected, and, (b) start with an empty image in a Cartesian (longitude, latitude) or (lon, lat) grid. For each pixel in (lon, lat) system find UTM cords and set the color of the pixel equal to the pixel with computed UTM cords. These approaches are described and discussed and results are presented.
Isolation, Culture, and Transplantation of Intrahepatic Biliary Epithelial Cells and Oval Cells (1990)

Recent advances made in the isolation, culture, and transplantation of defined populations of intrahepatic biliary epithelial cells and oval cells have permitted direct analysis of the functions, growth properties, and differentiation potential of these respective cell types in their untransformed or transformed states. This review provides a current and comprehensive examination of the various approaches that have been taken to isolate and culture intrahepatic biliary epithelial cells from normal and cholestatic liver and oval cells from preneoplastic liver. Emphasis is placed on comparing the phenotypic features and growth properties of these various biliary cell types in vitro as well as on describing their transplantation into ectopic tissue sites. In addition, the oval cell is evaluated in terms of its potential role as a 'facultative stem cell' during hepatocarcinogenesis.
Synthesis of Specific Bivalent Probes That Functionally Interact with 5-HT<sub>4</sub> Receptor Dimers (2007)

G-protein-coupled receptor dimerization directs the design of new drugs that specifically bind to receptor dimers. Here, we generated a targeted series of homobivalent ligands for serotonin 5-HT(4) receptor (5-HT(4)R) dimers composed of two 5-HT(4)R-specific ML10302 units linked by a spacer. The design of spacers was assisted by molecular modeling using our previously described 5-HT(4)R dimer model. Their syntheses were based on Sonogashira-Linstrumelle coupling methods. All compounds retained high-affinity binding to 5-HT(4)R but lost the agonistic character of the monomeric ML10302 compound. Direct evidence for the functional interaction of both pharmacophores of bivalent ligands with the 5-HT(4)R was obtained using a bioluminescence resonance energy transfer (BRET) based assay that monitors conformational changes within 5-HT(4) dimers. Whereas the monovalent ML10302 was inactive in this assay, several bivalent derivatives dose-dependently increased the BRET signal, indicating that both pharmacophores functionally interact with the 5-HT(4) dimer. These bivalent ligands may serve as a new basis for the synthesis of potential drugs for 5-HT(4)-associated disorders.
What is a gene, post-ENCODE? History and updated definition (2007)

While sequencing of the human genome surprised us with how many protein-coding genes there are, it did not fundamentally change our perspective on what a gene is. In contrast, the complex patterns of dispersed regulation and pervasive transcription uncovered by the ENCODE project, together with non-genic conservation and the abundance of noncoding RNA genes, have challenged the notion of the gene. To illustrate this, we review the evolution of operational definitions of a gene over the past century--from the abstract elements of heredity of Mendel and Morgan to the present-day ORFs enumerated in the sequence databanks. We then summarize the current ENCODE findings and provide a computational metaphor for the complexity. Finally, we propose a tentative update to the definition of a gene: A gene is a union of genomic sequences encoding a coherent set of potentially overlapping functional products. Our definition side-steps the complexities of regulation and transcription by removing the former altogether from the definition and arguing that final, functional gene products (rather than intermediate transcripts) should be used to group together entities associated with a single gene. It also manifests how integral the concept of biological function is in defining genes.
Serum evaluation of basic FGF in breast cancer patients. (1996)

Basic fibroblast growth factor (bFGF) is a potent endothelial cell mitogen found in a variety of normal and tumour tissues and is of prognostic relevance in human malignancies such as renal cell carcinoma and leukaemia. This study presents the data of 104 serum samples of 20 patients suffering from breast cancer. Mean serum levels of bFGF in these patients were 13.9 +/- 17. 1 (min 0, max 56.4) pg/ml and 2.4 +/- 5.9 (min 0, max 24.7) pg/ml, respectively (p = 0.01). Basic FGF reached a sensitivity of 61% at a specificity of 87% when applying a cut-off level of 5 pg/ml. A continuous increase of bFGF serum levels before the clinical detection of relapse (lead time) was seen in 3 out of 8 cases with a mean lead time of 4 months. Preoperative serum levels were not of prognostic value and showed no correlation with axillary lymph node metastasis. These preliminary results indicate that, in breast cancer patients, soluble bFGF may be useful in early detection of primary tumours, recurrences and monitoring of therapy.
BioBench: A Benchmark Suite of Bioinformatics Applications (2005)

Recent advances in bioinformatics and the significant increase in computational power available to researchers have made it possible to make better use of the vast amounts of genetic data that has been collected over the last two decades. As the uses of genetic data expand to include drug discovery and development of gene-based therapies, bioinformatics is destined to take its place in the forefront of scientific computing application domains. Despite the clear importance of this field, common bioinformatics applications and their implication on microarchitectural design have received scant attention from the computer architecture community so far. The availability of a common set of bioinformatics benchmarks could be the first step to motivate further research in this crucial area. To this end, this paper presents BioBench, a benchmark suite that represents a diverse set of bioinformatics applications. The first version of BioBench includes applications from different application domains, with a particular emphasis on mature genomics applications. The applications in the benchmark are described briefly, and basic execution characteristics obtained on a real processor are presented. Compared to SPEC INT and SPEC FP benchmarks, applications in BioBench display a higher percentage of load/store instructions, almost negligible floating-point operation content, and higher IPC than either SPEC INT or SPEC FP applications. Our evaluation suggests that bioinformatics applications have distinctly different characteristics from the applications in both of the mentioned SPEC suites; and our findings indicate that bioinformatics workloads can benefit from architectural improvements to memory bandwidth and techniques that exploit their high levels of ILP. The entire BioBench suite and accompanying reference data will be made freely available to researchers
Evaluating the Safety of Retroviral Vectors Based on Insertional Oncogene Activation and Blocked Differentiation in Cultured Thymocytes (2016)

Insertional oncogenesis due to retroviral (RV) vector integration has caused recurrent leukemia in multiple gene therapy trials, predominantly due to vector integration effects at the LMO2 locus. While currently available preclinical safety models have been used for evaluating vector safety, none have predicted or reproduced the recurrent LMO2 integrations seen in previous X-linked severe combined immunodeficiency (X-SCID) and Wiskott-Aldrich clinical gene therapy trials. We now describe a new assay for assessing vector safety that recapitulates naturally occurring insertions into Lmo2 and other T-cell proto-oncogenes leading to a preleukemic developmental arrest in primary murine thymocytes cultured in vitro. This assay was used to compare the relative oncogenic potential of a variety of gamma-RV and lentiviral vectors and to assess the risk conferred by various transcriptional elements contained in these genomes. Gamma-RV vectors that contained full viral long-terminal repeats were most prone to causing double negative 2 (DN2) arrest and led to repeated cases of Lmo2 pathway activation, while lentiviral vectors containing these same elements were significantly less prone to activate proto-oncogenes or cause DN2 arrest. This work provides a new preclinical assay that is especially relevant for assessing safety in SCID disorders and provides a new tool for designing safer RV vectors.
Metabolomics-based component profiling of Halomonas sp. KM-1 during different growth phases in poly(3-hydroxybutyrate) production (2013)

To investigate the relationship between the production of poly(3-hydroxybutyrate) (PHB) and metabolic changes during different growth phases, a non-sterile batch fermentation process involving an alkalophilic and halophilic bacterium, Halomonas sp. KM-1, was used. Intracellular metabolites were analyzed using gas chromatography-mass spectrometry to characterize the metabolic profile. Significant changes relating to PHB production were observed in the TCA cycle, lipid-synthesis and amino acid biosynthetic pathways were found to shift dramatically between the exponential growth and stationary phases. During the stationary phase, 17 metabolites were upregulated and a cell dry mass of 17.8 g/L that included 44.8% PHB was observed at 24h in 5% glucose-supplemented cultures, whereas 11 metabolites were upregulated and a cell dry mass of 38.4 g/L that included 73.7% PHB was observed at 36 h in 10% glucose-supplemented cultures. This study provides pattern analysis of metabolite regulation during PHB accumulation, indicating that multicomponent and phase-specific mechanisms are involved.
Effect of myocardial infarction on components of fibrinolytic system. (1977)

A systematic investigation of the fibrinolytic system during the period after acute myocardial infarction in 42 patients showed a progressive reduction of fibrinolytic activity, with the longest lysis times on days 4 to 5 after the event. There is a concomitant rise in the levels of fibrinogen, plasminogen, and antiplasmin; only the latter parallels the delay in lysis. After 12 to 15 months, normal lysis times and fibrinogen levels were found in 24 patients re-examined. It is concluded that the reduced fibrinolytic activity in these patients was a transient phenomenon after myocardial infarction.
Production, transport and injection of a cold non-magnetized electron beam for the recirculating linac (1988)

A new foilless diode with a non-magnetically immersed cathode was recently designed and built for the Sandia Recirculating Linear Accelerator (RLA). Because there is also no radial component of electric field at the cathode, the electron beam starts almost parallel and is matched to a solenoidal transport system with minimum increase in divergence and radius. The electrode emission surface is specified by an area covered with felt which undergoes explosive electron emission at low electrical field stresses (60 kV/cm). The 1.7-MV, 4.8-kA produced beam is transported 1.5 meters to the injection region of the racetrack via a system of solenoids and focusing coils. The maximum transverse velocity component at injection point (1.5 m downstream from the cathode surface) is BETA/sub /perpendicular// = 0.03 and the radius r = 2.8 cm which give a quite small beam emittance /var epsilon/ = 0.08 rad-cm. Three-dimensional numerical simulations suggest that tangential injection into the ion focusing regime (IFR) channel of the accelerator provides better beam-channel coupling. A 1.3-MV and 4-MV design are also described. 6 refs., 13 figs.
Designing DBMS support for the temporal dimension (1984)

article Designing DBMS support for the temporal dimension Share on Authors: V Lum View Profile , P Dadam View Profile , R Erbe View Profile , J Guenauer View Profile , P Pistor View Profile , G Walch View Profile , H Werner View Profile , J Woodfill View Profile Authors Info & Claims ACM SIGMOD RecordVolume 14Issue 2June 1984 pp 115–130https://doi.org/10.1145/971697.602276Online:01 June 1984Publication History 81citation417DownloadsMetricsTotal Citations81Total Downloads417Last 12 Months5Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Hybrid Survivability Schemes Achieving High Connection Availability With a Reduced Amount of Backup Resources [Invited] (2013)

Maximizing connection availability in wavelength division multiplexing (WDM) networks is critical because even small disruptions can cause huge data losses. However, there is a trade-off between the level of network survivability and the cost related to the backup resources to be provided. One-hundred percent survivability can be achieved by dedicated path protection (DPP) with multiple prereserved protection paths for each provisioned connection, i.e., DPP (1∶N). Unfortunately, the blocking probability performance of DPP (1∶N) is negatively affected by the large number of prereserved backup wavelengths standing by unutilized. On the other hand, path restoration (PR)-based solutions ensure good blocking performance at the expense of lower connection availability. The work in this paper aims at finding hybrid network survivability strategies that combine the benefits of both techniques (i.e., high availability with low blocking rate). More specifically, the paper focuses on a double link failure scenario and proposes two strategies. The first one couples DPP (1∶1) with path restoration (referred to as DPP+PR) to minimize the number of dropped connections. The second scheme adds the concept of backup reprovisioning (BR), referred to as DPP+BR+PR, in order to further increase the connection availability achieved by DPP+PR. Integer linear programming models for the implementation of the proposed schemes are formulated. Extensive performance evaluation conducted in a path-computation-element-based WDM network scenario shows that DPP+BR+PR and DPP+PR can significantly lower the blocking probability value compared to DPP (1∶2) without compromising too much in terms of connection availability.