gebhart/patrepeval huggingface dataset:
Platelet‐derived growth factor‐induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCγ (1999)

Sphingosine-1-phosphate, a sphingolipid metabolite, is involved in the mitogenic response of platelet-derived growth factor (PDGF) and is formed by activation of sphingosine kinase. We examined the effect of PDGF on sphingosine kinase activation in TRMP cells expressing wild-type or various mutant betaPDGF receptors. Sphingosine kinase was stimulated by PDGF in cells expressing wild-type receptors but not in cells expressing kinase-inactive receptors (R634). Cells expressing mutated PDGF receptors with phenylalanine substitutions at five major tyrosine phosphorylation sites 740/751/771/1009/1021 (F5 mutants), which are unable to associate with PLCgamma, phosphatidylinositol 3-kinase, Ras GTPase-activating protein, or protein tyrosine phosphatase SHP-2, not only failed to increase DNA synthesis in response to PDGF but also did not activate sphingosine kinase. Moreover, mutation of tyrosine-1021 of the PDGF receptor to phenylalanine, which impairs its association with PLCgamma, abrogated PDGF-induced activation of sphingosine kinase. In contrast, PDGF was still able to stimulate sphingosine kinase in cells expressing the PDGF receptor mutated at tyrosines 740/751 and 1009, responsible for binding of phosphatidylinositol 3-kinase and SHP-2, respectively. In agreement, PDGF did not stimulate sphingosine kinase activity in F5 receptor 'add-back' mutants in which association with the Ras GTPase-activating protein, phosphatidylinositol 3-kinase, or SHP-2 was individually restored. However, a mutant PDGF receptor that was able to bind PLCgamma (tyrosine-1021), but not other signaling proteins, restored sphingosine kinase sensitivity to PDGF. These data indicate that the tyrosine residue responsible for binding of PLCgamma is required for PDGF-induced activation of sphingosine kinase. Moreover, calcium mobilization downstream of PLCgamma, but not protein kinase C activation, appears to be required for stimulation of sphingosine kinase by PDGF.-Olivera, A., Edsall, J., Poulton, S., Kazlauskas, A., Spiegel, S. Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma.
MicroRNA-146a Downregulates NFκB Activity via Targeting TRAF6 and Functions as a Tumor Suppressor Having Strong Prognostic Implications in NK/T Cell Lymphoma (2011)

These results suggest that miR-146a might function as a potent tumor suppressor in NKTL and be useful for patient assessment and therapeutic targeting.
Arc Effect on Single-Phase Reclosing Time of a UHV Power Transmission Line (2004)

One of the important operational conditions of a single-circuit ultra-high-voltage transmission line is the power transmission by two phases during the clearance of a temporary single-phase short circuit. Such a condition may be sustained for an interval of 1 s without losing the dynamic stability of the system. The influence of the arc on the single-phase reclosing time of an ultra-high-voltage power transmission line is investigated on the basis of the primary and the secondary arc models incorporated into the transient program EMTP. The validity of the models used is proven by comparison with field test results on an actual 1150-kV power transmission line from Ekibastuz to Kokchetav in Northern Kazakhstan. The processes of this power transmission in the "dead time" of the single-phase reclosing cycle are simulated. It is shown in the paper that simplified short-circuit simulation without the incorporation of the dynamic arc model leads to erroneous results. Mathematical analysis and field experiments show that natural secondary arc extinguishing in a highly compensated 1150-kV power transmission line cannot be reached in a reasonable time (e.g., less than 1 s). It is shown in the paper that this problem can be solved by automatic phase shunting (APS) of the faulted phase.
Optical Data Storage '98 : 10-13 May, 1998, Aspen, Colorado (1998)

This is a collection of papers presented at the Optical Data Storage '98 conference covering a variety of relevant issues and topics.
Stable, highly-responsive and broadband photodetection based on large-area multilayered WS<sub>2</sub> films grown by pulsed-laser deposition (2015)

The progress in the field of graphene has aroused a renaissance of keen research interest in layered transition metal dichalcogenides (TMDs). Tungsten disulfide (WS2), a typical TMD with favorable semiconducting band gap and strong light-matter interaction, exhibits great potential for highly-responsive photodetection. However, WS2-based photodetection is currently unsatisfactory due to the low optical absorption (2%-10%) and poor carrier mobility (0.01-0.91 cm(2) V(-1) s(-1)) of the thin WS2 layers grown by chemical vapor deposition (CVD). Here, we introduce pulsed-laser deposition (PLD) to prepare multilayered WS2 films. Large-area WS2 films of the magnitude of cm(2) are achieved. Comparative measurements of a WS2-based photoresistor demonstrate its stable broadband photoresponse from 370 to 1064 nm, the broadest range demonstrated in WS2 photodetectors. Benefiting from the large optical absorbance (40%-85%) and high carrier mobility (31 cm(2) V(-1) s(-1)), the responsivity of the device approaches a high value of 0.51 A W(-1) in an ambient environment. Such a performance far surpasses the CVD-grown WS2-based photodetectors (μA W(-1)). In a vacuum environment, the responsivity is further enhanced to 0.70 A W(-1) along with an external quantum efficiency of 137% and a photodetectivity of 2.7 × 10(9) cm Hz(1/2) W(-1). These findings stress that the PLD-grown WS2 film may constitute a new paradigm for the next-generation stable, broadband and highly-responsive photodetectors.
The Crystalline state and the Mesophases of Cholesteryl Oleyl Carbonate (1979)

Abstract The preparation of pure crystalline cholsteryl oleyl carbonate is described. The melting point, the mesophase transition temperatures, and the enthalpy of the melting process are recorded, and a method of maintaining cholesteryl oleyl carbonate in a pure state over extended periods of time is suggested.
Arrested coalescence in Pickering emulsions (2011)

When two emulsion drops begin to coalesce, their complete fusion into a single spherical drop can sometimes be arrested in an intermediate shape if a rheological resistance offsets the Laplace pressure driving force. Arrested coalescence of droplets is important, both for its broad impact on commercial food production as well as its potential for fabricating novel anisotropic colloidal microstructures. We use a micromanipulation technique to demonstrate the dynamics of arrested coalescence between droplets with interfacially adsorbed colloids. Surface coverage of the droplets is precisely determined by a capillary aspiration technique and then their coalescence is studied in situ. Depending on their surface coverage, droplets can experience total coalescence, arrested coalescence or total stability. We use microscopic observations along with geometrical packing arguments to confirm that coalescence is arrested due to close-packed jamming of particles. The anisotropic Laplace stress within the arrested structure is balanced by the elastic modulus of the jammed interface and thus further relaxation of the arrested structure is halted. Precise mapping of the arrested coalescence regime at a microscopic scale helps us to anticipate its effects on bulk scale production of such anisotropic colloidal structures.
Automatic quantitation of localized <i>in vivo</i><sup>1</sup>H spectra with LCModel (2001)

The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model in vitro spectra from individual metabolite solutions. Complete model spectra, rather than individual resonances, are used in order to incorporate maximum prior information into the analysis. A nearly model-free constrained regularization method automatically accounts for the baseline and lineshape in vivo without imposing a restrictive parameterized form on them. LCModel is automatic (non-interactive) with no subjective input. Approximately maximum-likelihood estimates of the metabolite concentrations and their uncertainties (Cramér-Rao lower bounds) are obtained. LCModel analyses of spectra from users with fields from 1.5 to 9.4 T and a wide range of sequences, particularly with short TE, are used here to illustrate the capabilities and limitations of LCModel and proton MRS.
Cost of acute renal failure requiring dialysis in the intensive care unit: Clinical and resource implications of renal recovery* (2003)

Immediate cost savings could be achieved by increasing the use of intermittent hemodialysis rather than CRRT for patients with acute renal failure in the intensive care unit. Because of the high cost of ongoing dialysis, CRRT may still be an economically efficient treatment if it improves renal recovery among survivors; further study in this area is required.
Analysis of operation mode of reflective liquid crystal display devices (1999)

The reflective liquid crystal display device having one polarizer was studied with the dynamic parameter space method. Device operation mode was analysed for both normally black and normally white operation conditions. The electro-optical responses and reflectance spectra were also studied for different operation modes. It was found that the optimized normally white modes for twist angles 180° and 220° of the reflective liquid crystal device have satisfactory contrast ratios and dispersion properties. For these twist angles, two equivalent normally white modes exist. The polarizer angles β1 of the first mode and β2 of the second mode have the simple relation β2 = 90° + β1.
Extracting general-purpose features from LIDAR data (2010)

The detection of features from Light Detection and Ranging (LIDAR) data is a fundamental component of feature-based mapping and SLAM systems. Existing detectors tend to exploit characteristics of specific environments: corners and lines from indoor (rectilinear) environments, and trees from outdoor environments. While these detectors work well in their intended environments, their performance in different environments can be very poor. We describe a general purpose feature detector for LIDAR data that is applicable to virtually any environment. Our methods adapt classic feature detection methods from the image processing literature, specifically the multi-scale Kanade-Tomasi corner detector. Our resulting method is capable of identifying stable features at a variety of spatial scales and produces uncertainty estimates for use in a state estimation algorithm. We present results on standard datasets, including Victoria Park and Intel Research Center (both 2D), and the MIT DARPA Urban Challenge dataset (3D).
Fast Algorithms for Resource Allocation in Wireless Cellular Networks (2009)

We consider a scheduled orthogonal frequency division multiplexed (OFDM) wireless cellular network where the channels from the base-station to the n mobile users undergo flat fading. Spectral resources are to be divided among the users in order to maximize total user utility. We show that this problem can be cast as a nonlinear convex optimization problem, and describe an O(n) algorithm to solve it. Computational experiments show that the algorithm typically converges in around 25 iterations, where each iteration has a cost that is O(n), with a modest constant. When the algorithm starts from an initial resource allocation that is close to optimal, convergence typically takes even fewer iterations. Thus, the algorithm can efficiently track the optimal resource allocation as the channel conditions change due to fading. We also show how our techniques can be extended to solve resource allocation problems that arise in wideband networks with frequency selective fading and when the utility of a user is also a function of the resource allocations in the past.
Differential Changes in Monoamine Oxidase A and B Activity in the Aging Rat Brain (1980)

The activity of monoamine oxidase (MAO) was assayed in the brains of young adult (7-8 weeks old) and aging (95-104 weeks old) male Sprague-Dawley rats. When expressed per milligramme of tissue, total protein content was increased to a similar extent in whole brain and in all seven brain regions of the aging rat, whereas MAO A activity (assayed by using 5-hydroxytryptamine as substrate) was unchanged in whole brain but increased in the cerebellum, and fell in the brainstem, midbrain, hippocampus, and cortex; and MAO B activity (assayed by using beta-phenylethylamine as substrate) increased in whole brain and all regions, except the brainstem. Age-related changes in total protein, MAO A and MAO B were thus independent of each other. Kinetic studies indicated that the Vmax of MAO B was increased in aging rat brain, whereas the Km was unaltered. The increase in MAO B activity was restricted to the extrasynaptosomal mitochondrial fraction of the aging brain, whereas a reduction in MAO A activity was found in the intrasynaptosomal, but not the extrasynaptosomal mitochondrial fraction.
Effect of Genotype, Flowering Date, and Environment on Oil Content and Oil Quality of Wild Sunflower Seed<sup>1</sup> (1983)

The effects of environmental conditions during sunflower ( Helianthus annuus L.) seed development and maturation on the final oil content of seed and composition of the oil have been studied extensively in commercial sunflower, but very little is known about the wild sunflower ( H. annuus L.). Neither is there much known about the sequential changes that occur in seed and oil during seed development and maturation. A better understanding of these changes could lead to a greater utilization of wild sunflower in breeding programs. The objective of this study was to determine the influence of genotype, flowering date, and environment on oil content and oil quality of maturing wild sunflower. Thirty‐eight populations of wild annual sunflower indigenous to areas from 29° to 46° N Lat and 81° to 122° W Long were planted in a randomized field plot design on 12 May 1980. Five heads per population per week were sibbed or interpollinated, and seeds were collected 28 days later for determination of oil content, fatty acid composition of oil, seed weight, and test weight. Flowering date and genotypes (populations) significantly affected all dependent variables. Oil content averaged over all populations increased from the first to last sampling. This is opposite the trend found in commercial hybrids. Oleic and linoleic acid concentrations of the oil decreased and increased, respectively, for later flowering dates. Oleic and linoleic acids began at lower and higher levels, respectively, in the wild sunflower compared to the commercial hybrid but all were about the same concentration at the last samplings. Based on multiple regressions, daylength and Julian day significantly influenced oil content. Linoleic acid was significantly influenced by Julian day, total solar radiation, and maximum temperature; whereas, oleic acid was influenced only by the latter two factors. Oil content and linoleic acid concentration differed significantly in seeds of the original population vs. the seeds grown at a single location. Sibbed and open‐pollinated seeds did not differ in total oil content when grown at a single location, but linoleic acid did. Oleic acid concentrations of sibbed and open‐pollinated seeds of populations grown at a single location did not differ significantly from the seeds of the original populations.
Moving Out of the Lab: Deploying Pervasive Technologies in a Hospital (2006)

The authors deployed a distributed system containing a location-tracking system, a context-awareness system, wall-sized displays, and mobile phones in a Danish hospital's operating ward. This article presents the lessons they learned from deploying these pervasive computing technologies and a checklist of questions for researchers to consider relating to hardware, software, and organizational issues when moving pervasive systems out of the laboratory. This article is part of a special issue on Real-World Deployments.
Refractive variability using automated isentropic cross-section analysis (2002)

This report describes a computerized method for constructing vertical cross-sections of atmospheric refractivity and other properties, based on radiosonde measurements of temperature, humidity and pressure versus altitude. A sequence of individual radiosonde profiles provides information at separated locations in space or time. To facilitate recognition of trends and patterns in the refractive structure, and use of range-dependent propagation assessment models such as RPO (Hitney, 1992), additional data points must be determined at a higher lateral resolution than the profile spacing. An interpolative scheme has been developed, employing procedures intended to yield physically acceptable estimates of the intervening thermal and refractive conditions. Gridded fields of refractivity and other parameters are produced in an isentropic coordinate system which naturally preserves significant vertical details in the atmospheric structure indicated at the given profile locations. Examples of application to a VOCAR upper-air data set are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Yeast bleomycin hydrolase is a DNA-binding cysteine protease. Identification, purification, biochemical characterization. (1994)

Bleomycin (BLM) is a DNA binding and damaging antibiotic produced by Streptomyces verticillus that has been used as an anti-tumor drug for various human cancers. The mammalian BLM hydrolase is a cysteine protease that inactivates BLM to relieve the toxicity of BLM to normal and tumor cells. The normal physiological function of BLM hydrolase is not known, but its activity limits the use of BLM in cancer chemotherapy. We have discovered a DNA binding activity for the yeast homolog of the mammalian BLM hydrolase in the course of studying the interaction of GAL4, a DNA-binding transcription factor, with its DNA recognition sites. Using gel mobility shift assays, we have purified a protein from yeast that binds specifically to the GAL4 DNA-binding sites. The purified protein is a tetramer of a 48-kDa polypeptide. The gene encoding the 48-kDa polypeptide was cloned and has a high homology to rabbit BLM hydrolase. The purified protein was confirmed to have a cysteine protease activity that can hydrolyze and inactivate BLM in vitro. We have established the optimal conditions for the protease activity of this protein and biochemically characterized its DNA binding activity. This protein binds both single- and double-stranded forms of the GAL4 DNA-binding sites with high affinity (10 nM to single strand and 1 microM to double strand). Its DNA binding activity is heat stable and resistant to various detergents. This protein may represent the first example of a eukaryotic DNA-binding protease. The discovery of a DNA binding activity for BLM hydrolase suggests an in vivo interaction between it and BLM on DNA.
Coding and Detection Schemes for Ambient Backscatter Communication Systems (2017)

Ambient backscatter technology has attracted much attention recently, because it enables battery-free devices, such as tags or sensors, to communicate through wireless energy harvesting and radio backscattering. Existing studies about ambient backscatter assume that the tags have only two states: backscatter or non-backscatter. Actually, some references have shown that the tags can readily realize three states: positive and negative phase backscatter, and non-backscatter. In this paper, we propose a new coding scheme for these tags with three states to improve the throughput of the ambient backscatter communication system. We then design a maximum a posteriori (MAP) detector for the reader to extract binary information from ternary coded signals. We also analyze the detection performance in terms of closed-form bit error rate (BER) expressions. It is found that the proposed coding scheme can improve the throughput of an ambient backscatter system, and there exists an error floor for the BER curve. Finally, simulation results are provided to corroborate our theoretical studies.
An Interindustry Model for Indicative, Regional Water Resource Planning: Some Preliminary Results (1973)

Resource economists, planners, and local, state and regional officials have long been concerned with water quality and supply management issues within the New England area. The primary responsibility for the planning and implementation of the majority of water resource programs within the region rests with local and state authorities. There are, however, efforts to approach many water supply and quality problems, particularly those which extend over a number of municipal and state jurisdictions, on a coordinated, regional basis, for example, through the various federal-state River Basins Commissions established throughout the United States.
Synthesis and characterization of novel aromatic-aliphatic poly(amide-imide-imide)s (PAII) (1999)

Novel poly(amide-imide-imide)s (PAII) were prepared by polycondensation of a new monomer synthesized from trimellitic anhydride and glutamic acid, followed by reflux condensing with thionyl chloride and several diamines. Polymers and monomers were characterized by 1H NMR and FT-IR spectroscopy, elemental analysis and mass spectrometry. Inherent viscosities of the resulting polymers were in the range of 17–26 mL g–1 (Mw 13 400–29 160, polydispersity (Mw/Mn) ca. 1.3–1.7), representing rather low molecular weights. The glass transition temperatures of the polymers were in the range of 210–285°C depending on the structure of diamines, and the thermal stability of the polymers was up to 400°C, comparable with that of polyimides and poly(amide imide)s. All the polymers synthesized are well soluble in aprotic polar solvents such as dimethylformamide, dimethyl sulfoxide, N-methyl-2-pyrrolidone and dimethylacetamide. Particularly, polymers containing oxydianiline and 4,4′-diaminodiphenyl sulfone were quite soluble in m-cresol, pyridine, nitrobenzene and tetrahydrofuran. Neuartige Poly(amid-imid-imid)e (PAII) wurden durch Polykondensation eines neuen, aus Trimellitsäureanhydrid und Glutaminsäure synthetisierten Monomeren und anschließende Kondensation mit Thionylchlorid und verschiedenen Diaminen hergestellt. Polymere und Monomere wurden mit 1H-NMR- und FT-IR-Spektroskopie, Elementaranalyse und Massenspektrometrie charakterisiert. Die inhärenten Viskositäten der hergestellten Polymeren betragen zwischen 17 und 26 mL g–1 (Mw 13 400–29 160, Uneinheitlichkeit (Mw/Mn) ca. 1.3–1.7), entsprechend den relativ niedrigen Molekulargewichten. Die Glasübergangstemperaturen der Polymeren liegen je nach der Struktur des Diamins im Bereich von 210°C bis 285°C. Die Polymeren sind bis etwa 400°C thermisch stabil, was etwa mit der Temperaturbeständigkeit von Polyimiden und Poly(amid-imid)en vergleichbar ist. Alle hergestellten Polymeren sind gut löslich in aprotischen polaren Lösemitteln wie Dimethylformamid, Dimethylsulfoxid, N-Methyl-2-pyrrolidinon und Dimethylacetamid. Insbesondere die Oxydianilin und 4,4′-Diaminodiphenylsulfon enthaltenden Polymeren sind gut in m-Kresol, Pyridin, Nitrobenzol und Tetrahydrofuran löslich.