gebhart/patrepeval huggingface dataset:
Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung (2006)

7131 Background: Investigate the safety and pharmacokinetics of aerosolized SLIT (Sustained release Lipid Inhalation Targeting) cisplatin in patients with carcinoma of the lung. Methods: In this single-center, dose-escalating study patients received SLIT cisplatin for a maximum of 6 cycles. The dose level defines the cycle duration and number of inhalations per day. Safety data, including laboratory parameters, adverse events, pulmonary function tests, bronchial responsiveness, and radiographic imaging were collected and analyzed for all patients in order to determine toxicity. Pharmacokinetic data was collected during the first treatment course. Results: 17 patients and 1 patient on compassionate use received treatment. SLIT cisplatin was well tolerated. No dose limiting toxicity was observed. The maximum delivered dose was 60 mg/m 2 in a 2 week schedule and 40 mg/m 2 on a weekly schedule. Safety data showed no hematological toxicity, nephrotoxicity, ototoxicity, or neurotoxicity. Common side effects were nausea (66.7%), vomiting (44.4%), dyspnea (66.7%), hoarseness (27.8%), and fatigue (66.7%). Pharmacokinetic data showed very low systemic concentrations only at the higher doses. CTC grade-2 decrease in FEV1 and DLCO occurred both in 2 patients after 1 course, and grade-1 decrease in FEV1 and DLCO in 6 and 4 patients respectively. Best overall response was stable disease in 13 patients, while 4 had progressive disease (1 patient received only one course). These results indicate that high doses of aerosolized SLIT cisplatin can be inhaled safely. The therapeutic effect of the formulation will be tested in a phase II study. Conclusions: Inhaled SLIT cisplatin was found to be feasible and safe in patients with lung cancer. [Table: see text]
Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains. (1992)

The Drosophila pair-rule gene, hairy (h), encodes a nuclear basic helix-loop-helix (bHLH) protein that regulates embryonic segmentation and adult bristle patterning. In both cases, the h protein behaves as a transcriptional repressor. In this study, we determined the molecular nature of 12 h alleles. One mutation maps within the HLH domain, consistent with h function requiring homodimerization or heterodimerization with other HLH proteins. A second mutation lies in the basic domain, suggesting that DNA binding is required for h activity. Several mutations show that the h C terminus, in particular the WRPW domain, is also required for h activity, perhaps by interacting with other proteins to mediate transcriptional repression. We show that the h protein in Drosophila virilis closely resembles that in D. melanogaster and includes completely conserved bHLH and WRPW domains.
Synthesized High-Frequency Thyristor for Dielectric Barrier Discharge Excimer Lamps (2011)

Dielectric barrier discharge (DBD) lamps, being capacitive loads, must be associated with bidirectional current sources for an appropriate control of the transferred power. Pulsed current source supplies, which are known to offer very interesting performances, require specific power switches that are able to manage bidirectional voltage and unidirectional current at much higher frequencies (several hundreds of kilohertz) than commercial thyristors. This paper proposes the detailed design of such a high-speed synthesized thyristor, using discrete components: a MOSFET in series with a high-voltage (HV) diode and a logic circuit that controls its gate. This switch is associated with an optimized self-powered driver, which is a very efficient solution to handle the perturbations associated with the HV and high-frequency operation. Experimental application of this device for DBD excimer lamp supply is proposed.
An automated train dispatching system (2002)

The automated train dispatching system (ATDS) is a computerized fault tolerant train schedule tracking and status information system. It consists of thirty-eight DEC PC workstations interconnected by modems, thick and thin wire Ethernet and fiber optic cable to a central VAXft computer acting as a database server. Three DECserver 700s provide forty-eight ports to drive nine end of line printers and three hundred "Transit Information Display Sign" (TIDS) Displays. The ATDS will be used by dispatchers and tower operators to monitor and administer the movement of trains in their territory by providing an accurate, real time status of train location. The inner workings of the traditional paper intensive system used to "run the railroad" are examined. The problems common to this system are identified and their impact assessed. The functionality of the new system is described. The streamlined operations under the electronic system are explained together with a discussion of the problems encountered when implementing the new design. The impacts on not only railroad operations but other departments with respect to the introduction of new technology, new technology/work interface and organization structure are explored. Integration of the design into the overall modernization plans are explored and finally, the lessons learned in implementation of this project are listed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Propagation of Sonic Booms and other Weak Nonlinear Waves through Turbulence (1971)

The structure of weak shocks propagating over long distances through turbulence modeled by sound speed fluctuations is investigated. The equilibrium wave shape is governed by a balance between non-linear steepening and a dissipative mechanism due to acoustic scattering of high-frequency energy out of the incident wave direction. This scattered energy appears as perturbations arriving behind the shock. For conditions representative of sonic boom and explosion wave propagation over long distances the mean wave structure is governed by a Burgers' equation similar to that describing viscous shocks, the difference being that parameters describing the turbulent scattering appear in the dissipative term. The theoretical predictions agree in order of magnitude with experiments on atmospheric propagation of sonic boom and explosion waves.
Evaluation of Adaptive Impedance Tuning for Reducing the Form Factor of Handset Antennas (2014)

In this paper, we evaluate adaptive impedance tuning in combination with intrinsically unmatched antennas in order to reduce the form factor of handset antennas. Thereby, we are able to shrink the size of an antenna element by a factor of four compared to an intrinsically broadband matched antenna while maintaining a similar total efficiency in usage scenarios. The antenna concept is based on an unmatched coupling element in order to obtain a flat impedance behavior, which is relatively insensitive to the user interaction. It enables a broadband adaptive matching by a tunable <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\Pi$</tex> </formula> -section network using varactors. The network takes into account the parasitic effects of the impedance detector and the ESD protection circuit.
Identification of a Specific Exosite on Activated Protein C for Interaction with Protease-activated Receptor 1 (2007)

Activated protein C (APC) is a vitamin K-dependent plasma serine protease which down-regulates the clotting cascade by inactivating procoagulant factors Va and VIIIa by limited proteolysis. In addition to its anticoagulant effect, APC also exhibits cytoprotective and antiinflammatory activity through the endothelial protein C receptor-dependent cleavage of protease activated receptor 1 (PAR-1) on endothelial cells. Recent mutagenesis data have indicated that the basic residues of two surface loops including those on 39 and the Ca2+-binding 70-80 loops constitute interactive sites for both factors Va and VIIIa, thereby mediating the interaction of APC specifically with these procoagulant cofactors. The basic residues of both loops have been discovered to be dispensable for the interaction of APC with PAR-1. It is not known if a similar exosite-dependent interaction contributes to the specificity of APC recognition of PAR-1 on endothelial cells. In this study, we have identified two acidic residues on helix-162 (Glu-167 and Glu-170) on the protease domain of APC which are required for the protease interaction with PAR-1, but not for its interaction with the procoagulant cofactors. Thus, the substitution of either Glu-167 or Glu-170 with Ala eliminated the cytoprotective signaling properties of APC without affecting its anticoagulant activity. These mutants provide useful tools for initiating in vivo studies to understand the extent to which the anticoagulant versus antiinflammatory activity of APC contributes to its beneficial effect in treating severe sepsis.
Multitone testing of sound system components: Some results and conclusions, Part 1: History and theory (2001)

An historical retrospective analysis of the measurement of nonlinearities in audio is carried out. A quantitative analysis of the responses of various nonlinear systems (theoretical and experimental) to a multitone signal is made, and multitone testing is compared to conventional harmonic and intermodulation measurements. The multitone test provides more accurate information about the behavior of nonlinear systems when compared to standard harmonic, two-tone intermodulation, and total harmonic distortion measurements. Modeling of the nonlinear reaction of various sound system components to a multitone signal is described.
Inhibitory Effects of a Novel Synthetic Protease Inhibitor, FUT-175, on the Paw Edema in Rats and Zymosan-induced Complement Activation in Vitro (1986)

FUT-175 inhibited the zymosan-induced rat paw edema in a dose-dependent manner, while indomethacin exhibited no significant activities in this model. FUT-175 also inhibited the decrease in hemolytic complement (CH50) induced by zymosan in vitro, and indomethacin was inactive. These results suggest that FUT-175 has potent in vitro and in vivo inhibitory activity against the activation of the complement system induced by zymosan.
The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design (2016)

Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with significant morbidity and mortality, and a huge cost. Since resistance to the existing anti-influenza drugs is rising, innovative inhibitors with a different mode of action are urgently needed. The influenza polymerase complex is widely recognized as a key drug target, given its critical role in virus replication and high degree of conservation among influenza A (of human or zoonotic origin) and B viruses. We here review the major progress that has been made in recent years in unravelling the structure and functions of this protein complex, enabling structure-aided drug design toward the core regions of the PA endonuclease, PB1 polymerase, or cap-binding PB2 subunit. Alternatively, inhibitors may target a protein-protein interaction site, a cellular factor involved in viral RNA synthesis, the viral RNA itself, or the nucleoprotein component of the viral ribonucleoprotein. The latest advances made for these diverse pharmacological targets have yielded agents in advanced (i.e., favipiravir and VX-787) or early clinical testing, besides several experimental inhibitors in various stages of development, which are all covered here.
Permutation Generation Methods (1977)

This paper surveys the numerous methods that have been proposed for permutatmn enumeration by computer. The various algorithms which have been developed over the years are described in detail, and zmplemented in a modern ALc, oL-hke language. All of the algorithms are derived from one rumple control structure.
Nonlinear Noise Monitoring in Coherent Systems Using Amplitude Modulation Pilot Tone and Zero-Power Gap (2019)

We propose a new method to monitor fiber nonlinear noise power using amplitude modulation pilot-tone and zero-power gap. The direct nonlinear noise monitoring was verified experimentally in multi-channel transmission over a 600-km SSFM link.
Lipid bilayer and cytoskeletal interactions in a red blood cell (2013)

We study the biomechanical interactions between the lipid bilayer and the cytoskeleton in a red blood cell (RBC) by developing a general framework for mesoscopic simulations. We treated the lipid bilayer and the cytoskeleton as two distinct components and developed a unique whole-cell model of the RBC, using dissipative particle dynamics (DPD). The model is validated by comparing the predicted results with measurements from four different and independent experiments. First, we simulated the micropipette aspiration and quantified the cytoskeletal deformation. Second, we studied the membrane fluctuations of healthy RBCs and RBCs parasitized to different intraerythrocytic stages by the malaria-inducing parasite Plasmodium falciparum. Third, we subjected the RBC to shear flow and investigated the dependence of its tank-treading frequency on shear rate. Finally, we simulated the bilayer-cytoskeletal detachment in channel flow to quantify the strength of such interactions when the corresponding bonds break. Taken together, these experiments and corresponding systematic DPD simulations probe the governing constitutive response of the cytoskeleton, elastic stiffness, viscous friction, and strength of bilayer-cytoskeletal interactions as well as membrane viscosities. Hence, the DPD simulations and comparisons with available independent experiments serve as validation of the unique two-component model and lead to useful insights into the biomechanical interactions between the lipid bilayer and the cytoskeleton of the RBC. Furthermore, they provide a basis for further studies to probe cell mechanistic processes in health and disease in a manner that guides the design and interpretation of experiments and to develop simulations of phenomena that cannot be studied systematically by experiments alone.
TWIST and ovarian cancer stem cells: implications for chemoresistance and metastasis (2014)

The transcription factor TWIST1 is a highly evolutionally conserved basic Helix-Loop-Helix (bHLH) transcription factor that functions as a master regulator of gastrulation and mesodermal development. Although TWIST1 was initially associated with embryo development, an increasing number of studies have shown TWIST1 role in the regulation of tissue homeostasis, primarily as a regulator of inflammation. More recently, TWIST1 has been found to be involved in the process of tumor metastasis through the regulation of Epithelial Mesenchymal Transition (EMT). The objective of this review is to examine the normal functions of TWIST1 and its role in tumor development, with a particular focus on ovarian cancer. We discuss the potential role of TWIST1 in the context of ovarian cancer stem cells and its influence in the process of tumor formation.
(Online) Subgradient Methods for Structured Prediction (2018)

Promising approaches to structured learning problems have recently been developed in the maximum margin framework. Unfortunately, algorithms that are computationally and memory eﬃcient enough to solve large scale problems have lagged behind. We propose using simple subgradient-based techniques for optimizing a regularized risk formulation of these problems in both online and batch settings, and analyze the theoretical convergence, generalization, and robustness properties of the resulting techniques. These algorithms are are simple, memory eﬃcient, fast to converge, and have small regret in the online setting. We also investigate a novel convex regression formulation of structured learning. Finally, we demonstrate the beneﬁts of the subgradient approach on three structured prediction problems.
An efficient encoding method for electrocardiography using spline functions (1985)

Abstract This paper proposes a highly efficient encoding method for electrocardiogram using spline functions. The method consists of the extraction algorithm, which extracts feature samples from the electrocardiogram from the A/D converter, and the restoration algorithm which restores the original waveform from the extracted samples, using spline functions. In the extraction algorithm, maxima and minima, which is not due to noise, are extracted from the original waveform. Then the spline function is applied to perform a smooth interpolation. By this scheme, a highly accurate approximation is realized, which has not been achieved by the linear approximation using the traditional AZTEC method. According to the result of experiment, the root‐mean‐square error of the proposed method is approximately half the AZTEC method if the compression ratio is the same. The proposed method consists in the simple extraction algorithm, and can be implemented on a microprocessor. Thus, it is suited to the long‐term monitoring of the electrocardiogram to record abnormal waveforms.
Thermodynamic and structural aspects of the interaction between macrocyclic polyammonium cations and complexed anions (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamic and structural aspects of the interaction between macrocyclic polyammonium cations and complexed anionsAndrea Bencini, Antonio Bianchi, Paolo Dapporto, Enrique Garcia-Espana, Mauro Micheloni, Jose Antonio Ramirez, Piero Paoletti, and Paola PaoliCite this: Inorg. Chem. 1992, 31, 10, 1902–1908Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/ic00036a033https://doi.org/10.1021/ic00036a033research-articleACS PublicationsRequest reuse permissionsArticle Views117Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
CD4 <sup>+</sup> T Cells from IPEX Patients Convert into Functional and Stable Regulatory T Cells by <i>FOXP3</i> Gene Transfer (2013)

In humans, mutations in the gene encoding for forkhead box P3 (FOXP3), a critically important transcription factor for CD4⁺CD25⁺ regulatory T (T(reg)) cell function, lead to a life-threatening systemic poly-autoimmune disease, known as immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Severe autoimmunity results from the inborn dysfunction and instability of FOXP3-mutated T(reg) cells. Hematopoietic stem cell transplantation is the only current curative option for affected patients. We show here that when CD4⁺ T cells are converted into T(reg) cells after lentivirus-mediated FOXP3 gene transfer, the resulting CD4(FOXP3) T cell population displays stable phenotype and suppressive function, especially when naïve T cells are converted. We further demonstrate that CD4(FOXP3) T cells are stable in inflammatory conditions not only in vitro but also in vivo in a model of xenogeneic graft-versus-host disease. We therefore applied this FOXP3 gene transfer strategy for the development of a T(reg) cell-based therapeutic approach to restore tolerance in IPEX syndrome. IPEX-derived CD4(FOXP3) T cells mirrored T(reg) cells from healthy donors in terms of cellular markers, anergic phenotype, cytokine production, and suppressive function. These findings pave the way for the treatment of IPEX patients by adoptive cell therapy with genetically engineered T(reg) cells and are seminal for future potential application in patients with autoimmune disorders of different origin.
The stannic oxide gas sensor (1994)

Outlines the characteristics and applications of the stannic oxide sensor. Describes the manufacturing process and properties of stannic oxide and concludes that with modern development in tin dioxide‐based sensors their application is set to expand from their present role in domestic, commercial and industrial alarms to monitoring instruments as well.
Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic encephalopathy (2008)

Abnormal pituitary hormone and melatonin circadian patterns are present in cirrhosis before the development of hepatic encephalopathy. These abnormalities may be early indicators of impending hepatic encephalopathy. Factors affecting the human biologic clock at the early stages of liver insufficiency require further study.
'Smart', remote holographic processor based on the materials characteristics of LiNbO3 (1978)

A class of 'Smart' remote holographic processors based on the material characteristics of LiNbO3 is introduced. The processors rely on holographic subtraction to detect differences in optical wavefronts that are spatially modulated to reflect either incoming or reference information. The state of the art of their fabrication and performance is described in the following paper. This paper outlines the principles of holography and photorefractivity that make these processors possible. Particular emphasis is placed on a potential mode of operation termed self-subtraction, in which the holographic processor is able to adapt to changes in reference information without the need for commands from an external operator.
Metal Ion Site Engineering Indicates a Global Toggle Switch Model for Seven-transmembrane Receptor Activation (2006)

Much evidence indicates that, during activation of seven-transmembrane (7TM) receptors, the intracellular segments of the transmembrane helices (TMs) move apart with large amplitude, rigid body movements of especially TM-VI and TM-VII. In this study, AspIII:08 (Asp113), the anchor point for monoamine binding in TM-III, was used as the starting point to engineer activating metal ion sites between the extracellular segments of the beta2-adrenergic receptor. Cu(II) and Zn(II) alone and in complex with aromatic chelators acted as potent (EC50 decreased to 0.5 microm) and efficacious agonists in sites constructed between positions III:08 (Asp or His), VI:16 (preferentially Cys), and/or VII:06 (preferentially Cys). In molecular models built over the backbone conformation of the inactive rhodopsin structure, the heavy atoms that coordinate the metal ion were located too far away from each other to form high affinity metal ion sites in both the bidentate and potential tridentate settings. This indicates that the residues involved in the main ligand-binding pocket will have to move closer to each other during receptor activation. On the basis of the distance constraints from these activating metal ion sites, we propose a global toggle switch mechanism for 7TM receptor activation in which inward movement of the extracellular segments of especially TM-VI and, to some extent, TM-VII is coupled to the well established outward movement of the intracellular segments of these helices. We suggest that the pivots for these vertical seesaw movements are the highly conserved proline bends of the involved helices.