gebhart/patrepeval huggingface dataset:
Combined treatment using adoptive cell therapy, extended pharmacokinetic IL-2, and tumor-specific antibodies leads to cures of established B16F10 tumors and extended in vivo T cell survival (2013)

Meeting abstracts IL2 is frequently given alongside adoptive cell therapy in order to enhance T cell function and survival, however, the protein has a poor pharmacokinetic profile and severe negative side effects. Fc-IL2 is a monovalent Fc fusion with IL2. The addition of the Fc domain to the
Temporomandibular Disorders and Occlusion: An Appliance to Treat Occlusion Generated Symptoms of TMD in Patients Presenting with Deficient Anterior Guidance (1994)

Temporomandibular disorders (TMD) are of multifactorial origin. If it is determined that the patient's occlusal scheme is a contributing factor to their TMD symptoms, it is accepted that reversible, noninvasive procedures be instituted at the outset of treatment. Splint therapy conforms to this guideline, offering temporary, reversible alteration of the occlusal scheme in order to provide this relief. In a mutually protected occlusion, the posterior teeth accept the occlusal force of closure, while the anterior teeth separate the dentition during excursive movements. The purpose of the disclusion splint described in this article is to eliminate muscle hypertonicity, along with its ensuing problems. This is accomplished by establishing a mutually protected occlusion via the guide planes created by the acrylic portions of the splint, but not compromising the patient's "freeway" space.
Cutting Forces in Machining and Their Routine Measurement with Multi-Component Piezo-Electric Force Transducers (1972)

Knowledge of actual cutting forces in machining is becoming of paramount importance to both designers and users of machine tools, because optimum machine performance, tool selection, tool life, cutting-edge geometry, combination of tool and material to be machined, accuracy and so on are closely related to the resulting cutting forces. Transducers and platforms for measuring forces in 1, 2 or 3 components and/or torques have been developed and are described here. Quartz is used as the piezo-electric transducer material because it provides extremely high rigidity and excellent dynamic response as well as minimal cross-talk between components. In contrast to other measuring systems, such platforms equal or exceed usual tool holders in terms of rigidity, thus permitting realistic, precise measurements. Practical aspects such as cross-talk between components, frequency response, measuring and recording techniques are discussed and the possibilities of adaptive control by directly mounting transducers into machine tools outlined.
High-Resolution Twin-Ion Metabolite Extraction (HiTIME) Mass Spectrometry: Nontargeted Detection of Unknown Drug Metabolites by Isotope Labeling, Liquid Chromatography Mass Spectrometry, and Automated High-Performance Computing (2015)

The metabolic fate of a compound can often determine the success of a new drug lead. Thus, significant effort is directed toward identifying the metabolites formed from a given molecule. Here, an automated and nontargeted procedure is introduced for detecting drug metabolites without authentic metabolite standards via the use of stable isotope labeling, liquid chromatography mass spectrometry (LC/MS), and high-performance computing. LC/MS of blood plasma extracts from rats that were administered a 1:1 mixture of acetaminophen (APAP) and (13)C6-APAP resulted in mass spectra that contained "twin" ions for drug metabolites that were not detected in control spectra (i.e., no APAP administered). Because of the development of a program (high-resolution twin-ion metabolite extraction; HiTIME) that can identify twin-ions in high-resolution mass spectra without centroiding (i.e., reduction of mass spectral peaks to single data points), 9 doublets corresponding to APAP metabolites were identified. This is nearly twice that obtained by use of existing programs that make use of centroiding to reduce computational cost under these conditions with a quadrupole time-of-flight mass spectrometer. By a manual search for all reported APAP metabolite ions, no additional twin-ion signals were assigned. These data indicate that all the major metabolites of APAP and multiple low-abundance metabolites (e.g., acetaminophen hydroxy- and methoxysulfate) that are rarely reported were detected. This methodology can be used to detect drug metabolites without prior knowledge of their identity. HiTIME is freely available from https://github.com/bjpop/HiTIME .
Specificity of antibody response to 23-valent pneumococcal polysaccharide vaccine in patients with chronic pulmonary diseases (2010)

Objective To study the specificity of the serotype-specific IgG in the sera of patients with chronic pulmonary diseases(CPD)after pneumococcal vaccination.Methods Serotype-specific IgG concentrations were measured by the second and third(with more specificity)generation ELISA for serotype 6B,19F and 23F in 39 CPD patients after vaccinated with 23-valent pneumococcal polysaccharide vaccine(PPV).Results The serotype-specific IgG levels measured by the third-generation ELISA were much lower than those by the second-generation ELISA.About half of the anti-CPS IgG in the sera of CPD patients was non-specific antibody whether natural infection or vaccination.Conclusion PPV can not improve the proportion of serotype-specific antibodies in the sera of patients with CPD.
3.28-Tb/s transmission over 3 x 100 km of nonzero-dispersion fiber using dual C- and L-band distributed Raman amplification (2000)

A record aggregate capacity of 3.28-Tb/s (82/spl times/40 Gb/s NRZ) is transmitted over 3/spl times/100 km of nonzero-dispersion fiber. The system incorporates for the first time dual C- and L-band transmission and distributed Raman amplification in addition to the 40-Gb/s NRZ line rate.
Color image enhancement by highlight-preserving vector transformation and nonlinear mapping (2002)

In this paper, a new light-value approaching method to enhance a color image by excluding the effect of incident illumination is proposed. The method uses the highlight-presenting vector transformation, in which the estimated color of illumination is transformed to the white color of natural daylight while preserving the highlight. In the method, the initial transformation matrix using simple vector rotation is corrected by regression, and the corrected transformation matrix is applied to input color. Then the transformed red, green, and blue values of each pixel are nonlinearly mapped to the 8 bit values to be displayed on a natural color output device. The proposed method can produce the enhanced color image fast and efficiently without any space conversion or noticeable distortion.
Effect of Flash Glucose Monitoring on Glycemic Control, Hypoglycemia, Diabetes-Related Distress, and Resource Utilization in the Association of British Clinical Diabetologists (ABCD) Nationwide Audit (2020)

We show that the use of FSL was associated with significantly improved glycemic control and hypoglycemia awareness and a reduction in hospital admissions.
The Basal Cell Naevus Syndrome: Report of a Family with Anosmia and a Case of Hypogonadotrophic Hypopituitarism (1973)

A family with the naevoid basal cell carcinoma syndrome is described. Three affected members in one sibship suffered from anosmia. One member has shown a most severe constellation of defects including cataracts, hypertelorism, and anosmia, together with hypogonadism secondary to partial pituitary dysfunction. It is suggested that this latter also represents a previously unreported manifestation of the syndrome.
Dating the Cenancester of Organisms (1996)

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A heuristic for peak power constrained design of network-on-chip (NoC) based multimode systems (2005)

Designing NoC-based systems has become increasingly complex with support for multiple functionalities. Decisions regarding interconnections between the heterogeneous system components and routing of system communication affect system performance and power consumption. This research provides a heuristic to determine the neighborhood configuration for each component. By controlling the communication bandwidth allocation, simulation results with synthetic and real workloads indicate that our heuristic is able to control the peak power consumption, but at cost of throughput degradation.
Chaotic attractor prediction for server run-time energy consumption (2010)

This paper proposes a chaotic time series model of server system-wide energy consumption to capture the dynamics present in observed sensor readings of underlying physical systems. Based on the chaotic model, we have developed a real-time predictor that estimates actual server energy consumption according to its overall thermal envelope. This chaotic time series regression model relates processor power, bus activity, and system ambient temperatures for real-time prediction of power consumption during job execution to enable run-time control of their thermal impacts. An experimental case study compares our Chaotic Attractor Predictor (CAP) against previous prediction models constructed according to other statistical methods. Our CAP is found to be accurate within an average error of 2% (or 7%) and the worst case error of 7% (or 20%) for the AMD Opteron processor (or for the Intel Nehalem processor), based on executing a set of SPEC CPU2006 benchmarks.
Generalized SMASH imaging (2001)

A generalized parallel imaging method has been developed that uses coil profiles to generate missing k-space lines. The proposed method is an extension of SMASH, which uses linear combinations of coil sensitivity profiles to synthesize spatial harmonics. In the generalized SMASH approach described here, coil sensitivity profiles are represented directly in the Fourier domain to provide a general description of the spatial properties of the coils. This removes restrictions imposed by conventional SMASH, so that the choice and position of the receiver coils can be made on the basis of sensitivity to the volume of interest rather than suitability for constructing spatial harmonics. Generalized SMASH also intrinsically allows the freedom to accommodate acquisitions with uniform or nonuniform k-space sampling. The proposed method places SMASH on an equal footing with other parallel imaging techniques (SENSE and SPACE-RIP), while combining strengths from each. The method was tested on phantom and human data and provides a robust method of data recovery.
Two-Color Pixel Patterning for High-Resolution Organic Light-Emitting Displays Using Photolithography (2020)

Nowadays, the display industry is endeavoring to develop technology to provide large-area organic light-emitting diode (OLED) display panels with 8K or higher resolution. Although the selective deposition of organic molecules through shadow masks has proven to be the method of choice for mobile panels, it may not be so when independently defined high-resolution pixels are to be manufactured on a large substrate. This technical challenge motivated us to adopt the well-established photolithographic protocol to the OLED pixel patterning. In this study, we demonstrate the two-color OLED pixels integrated on a single substrate using a negative-tone highly fluorinated photoresist (PR) and fluorous solvents. Preliminary experiments were performed to examine the probable damaging effects of the developing and stripping processes upon a hole-transporting layer (HTL). No significant deterioration in the efficiency of the develop-processed device was observed. Efficiency of the device after lift-off was up to 72% relative to that of the reference device with no significant change in operating voltage. The procedure was repeated to successfully obtain two-color pixel arrays. Furthermore, the patterning of 15 μm green pixels was accomplished. It is expected that photolithography can provide a useful tool for the production of high-resolution large OLED displays in the near future.
ANALYSIS OF THE PRESSURE EFFECT ON THE CRYSTALLIZATION KINETICS OF POLYPROPYLENE: DILATOMETRIC MEASUREMENTS AND THERMAL GRADIENT MODELING (2001)

Abstract Dilatometric measurements in isobaric cooling mode were performed to study the pressure effects on the crystallization kinetics of polypropylene (PP) up to 100 MPa. The experimental specific volume curves were analyzed by taking into account the thermal gradient that appears in the sample even for relatively low cooling rates. The Tait equation was used to describe the specific volume of the purely amorphous phase, and linear variations of the purely crystalline phase specific volume are considered. The relative crystal linity was modeled using the Nakamura equation, which is relevant for non-constant cooling rates. Considering an Avrami exponent of 3, the Nakamura rate constant was obtained first at atmospheric pressure and then generalized for higher pressures considering the equilibrium melting temperature variation. The obtained intrinsic specific volume was validated by computing the thermal gradient in the sample and comparing the calculated average specific volume to the experimental one. Keywords: Crystallization kineticsNakamura equationPolypropylenePressure-volume-temperature measurementThermal modeling ACKNOWLEDGMENT We want to acknowledge gratefully the companies Legrand, Solvay, and Moldflow for the material supply and characterization and for financial support.
The preparation and properties of yeast β-fructofuranosidase chemically attached to polystyrene (1970)

1. A process is described for the chemical attachment of an enzyme to the surface of a polystyrene matrix. 2. By this process yeast beta-fructofuranosidase was chemically attached to the surface of both polystyrene beads and polystyrene tubes. 3. The kinetics of sucrose hydrolysis by beta-fructofuranosidase and polystyrene-supported beta-fructofuranosidase were compared. 4. The pH-activity curve of the polystyrene-supported enzyme shows a marked difference from that of the free enzyme in solution. 5. The inhibitor dissociation constant with respect to tris is increased, whereas the inhibitor dissociation constant with respect to aniline is decreased when the enzyme is attached to polystyrene. 6. Differences between the properties of the bound and free enzyme are discussed in terms of a micro-environmental effect arising from the hydrophobic nature of the polystyrene support.
Cell-wall protein profiles of dairy thermophilic lactobacilli (1997)

SDS-PAGE fingerprinting of cell-wall proteins extracted from 119 strains belonging to different species of lactic acid bacteria have been compared. The method of extraction and electrophoretic separation utilized in this work was found to be a reliable and rapid way for characterizing thermophilic lactobacilli species and strains. A protein of approximately 50 kDa was found to be characteristic for all the Lact. helveticus strains, and two cell-wall proteins of about 20 and 30 kDa were typical of the species Lact. delbrueckii, but the discrimination between the subspecies lactis and bulgaricus was not possible by the electrophoretic technique used. The other thermophilic species studied in this work presented cell-wall protein patterns that permitted their differentiation from both Lact. helveticus and Lact. delbrueckii.
<title>Sketch on dynamic gesture tracking and analysis exploiting vision-based 3D interface</title> (2000)

In this paper, we propose a vision-based 3D interface exploiting invisible 3D boxes, arranged in the personal space (i.e. reachable space by the body without traveling), which allows robust yet simple dynamic gesture tracking and analysis, without exploiting complicated sensor-based motion tracking systems. Vision-based gesture tracking and analysis is still a challenging problem, even though we have witnessed rapid advances in computer vision over the last few decades. The proposed framework consists of three main parts, i.e. (1) object segmentation without bluescreen and 3D box initialization with depth information, (2) movement tracking by observing how the body passes through the 3D boxes in the personal space and (3) movement feature extraction based on Laban's Effort theory and movement analysis by mapping features to meaningful symbols using time-delay neural networks. Obviously, exploiting depth information using multiview images improves the performance of gesture analysis by reducing the errors introduced by simple 2D interfaces In addition, the proposed box-based 3D interface lessens the difficulties in both tracking movement in 3D space and in extracting low-level features of the movement. Furthermore, the time-delay neural networks lessens the difficulties in movement analysis by training. Due to its simplicity and robustness, the framework will provide interactive systems, such as ATR I-cubed Tangible Music System or ATR Interactive Dance system, with improved quality of the 3D interface. The proposed simple framework also can be extended to other applications requiring dynamic gesture tracking and analysis on the fly.
DIoT: A Self-learning System for Detecting Compromised IoT Devices (2018)

IoT devices are being widely deployed. Many of them are vulnerable due to insecure implementations and configuration. As a result, many networks already have vulnerable devices that are easy to compromise. This has led to a new category of malware specifically targeting IoT devices. Existing intrusion detection techniques are not effective in detecting compromised IoT devices given the massive scale of the problem in terms of the number of different types of devices and manufacturers involved. In this paper, we present DIoT, a system for detecting compromised IoT devices effectively. In contrast to prior work, DIoT uses a novel self-learning approach to classify devices into device types and build normal communication profiles for each of these that can subsequently be used to detect anomalous deviations in communication patterns. DIoT is completely autonomous and can be trained in a distributed crowdsourced manner without requiring human intervention or labeled training data. Consequently, DIoT can cope with the emergence of new device types as well as new attacks. By systematic experiments using more than 30 off-the-shelf IoT devices, we show that DIoT is effective (94% detection rate) and fast (2 s.) at detecting devices compromised by the infamous Mirai malware. DIoT reported no false alarms when evaluated in a real-world deployment setting.
Resource aware real-time stream adaptation of MPEG-4 video in constrained bandwidth networks (2011)

In this paper, we propose a novel method for real- time stream adaptation of live MPEG-4 Visual advanced simple profile (ASP) and simple profile (SP) bit streams to limited and varying network bandwidth. The proposed method operates by dropping higher order AC DCT coefficients present in blocks. Unlike frame dropping, the proposed method delivers finer granularity during adaptation and therefore smaller resource under-utilization. Furthermore, to optimize the resource utilization and consequently the perceptive video quality, the method attempts to represent the adapted block with the least possible number of bits. The low computation requirements of the proposed method qualifies its application to adaptation of live streams. Additionally, the method can be applied for other constrained resources as well (e.g. CPU bandwidth). Implementation and case study of the proposed method show that, on an average, a bit rate reduction of up to 50% and a decoding time speedup up to 20% are achieved when compared with that of the original bitstream. Results also affirm the efficiency in resource usage.
The Interaction between Two Radiosensitizers: 5-Iododeoxyuridine and Caffeine (2006)

5-Iododeoxyuridine (IUdR) and caffeine are recognized as potential radiosensitizers with different mechanisms of interaction with ionizing radiation (IR). To assess the interaction of these two types of radiosensitizers, we compared treatment responses to these drugs alone and in combination with IR in two p53-proficient and p53-deficient pairs of human colon cancer cell lines (HCT116 versus HCT116 p53-/- and RKO versus RKO E6). Based on clonogenic survival, the three single agents (IR, IUdR, and caffeine) as well as IUdR or caffeine combined with IR are less or equally effective in p53-deficient human tumor cells compared with p53-proficient tumor cells. However, using both radiosensitizers, a significantly greater radiosensitization was found in p53-deficient human tumor cells. To better understand the interaction of these two radiosensitizers, additional studies on DNA repair and cell cycle regulation were done. We found that caffeine enhanced IUdR-DNA incorporation and IUdR-mediated radiosensitization by partially inhibiting repair (removal) of IUdR in DNA. The repair of IR-induced DNA double-strand breaks was also inhibited by caffeine. However, these effects of caffeine on IUdR-mediated radiosensitization were not found in p53-proficient cells. Cell cycle analyses also showed a greater abrogation of IR-induced S- and G2-phase arrests by caffeine in p53-deficient cells, particularly when combined with IUdR. Collectively, these data provide the mechanistic bases for combining these two radiosensitizers to enhance tumor cytotoxicity. This differential dual mode of radiosensitization by combining IUdR and caffeine-like drugs (e.g., UCN-01) in p53-deficient human tumors may lead to a greater therapeutic gain.
Adaptive coding of DCT coefficients by Golomb-Rice codes (2002)

In this paper we apply some of the Golomb-Rice coding techniques that emerged in JPEG-LS, a new standard for lossless image compression, and apply them towards coding DCT coefficients in the lossy JPEG baseline algorithm. We show that this results in significant improvements in performance with limited impact on computational complexity. In fact, one significant reduction in complexity provided by the proposed techniques is the complete elimination of the Huffman tables in JPEG baseline which can be a bottleneck in hardware implementations. We give simulation results, comparing the performance of the proposed technique to JPEG baseline, JPEG baseline with optimal Huffman coding (two pass) and JPEG arithmetic.
The Predictive Value of Sympathetic Block for the Success of Spinal Cord Stimulation (2003)

We conclude that patients with good response to SB before SCS are more likely to have a positive response during their SCS trial and long-term pain relief after placement of permanent SCS device.
Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection (2016)

Middle East Respiratory Syndrome coronavirus (MERS-CoV) has repeatedly caused outbreaks in the Arabian Peninsula. To date, no approved medical countermeasures (MCM) are available to combat MERS-CoV infections. Several neutralizing human monoclonal antibodies (mAbs), including m336, a germline-like human mAb, have been chosen as promising MCM for MERS-CoV. However, their clinical development has been hindered by the lack of a robust animal model that recapitulate the morbidity and mortality of human infections. We assessed the prophylactic and therapeutic efficacy of m336 by using well-characterized transgenic mice shown to be highly sensitive to MERS-CoV infection and disease. We found that mice treated with m336 prior to or post lethal MERS-CoV challenging were fully protected, compared to control mice which sufferered from profound weight loss and uniform death within days after infection. Taken together, these results support further development of m336 and other human monoclonal antibodies as potential therapeutics for MERS-CoV infection.