gebhart/patrepeval huggingface dataset:
A Geiger-mode avalanche photodiode array for X-ray photon correlation spectroscopy (2008)

X-ray photon correlation spectroscopy (XPCS) provides an opportunity to study the dynamics of systems by measuring the temporal fluctuations in a far-field diffraction pattern. A two-dimensional detector system has been developed to investigate fluctuations in the frequency range of several Hz to kHz. The X-ray detector system consists of a thin 100 microm scintillation crystal coupled to a Geiger-mode avalanche photodiode array. In this article the elements of the system are detailed and the detector for XPCS measurements is demonstrated.
ICIS: A Smart Look into the Future (2015)

ICIS is a prospective product introduced by the Boston-startup LAFORGE that is similar to Google Glass and where it stands against it. Icis is an eye wear which enables user to access their notifications, maps, and various other apps as being developed by Laforge and developers for the same. The features of Icis are enumerated as well as the specifications of the same. Icis allows one to access the smartphone without having to remove it from one's pocket. It accomplishes this using Bluetooth connectivity and creates the interface with the app SocialFlo. Icis boasts high functionality while making a fashion statement, all doing so at a much lower price than its Google made counterpart. Icis has a development program, open to the public to advance the functionality of the product. Finally, Icis is compared to Google Glasses and we take a glance at what we can expect in the future.
Brachymonas denitrificans gen. nov., sp. nov., an aerobic chemoorganotrophic bacterium which contains rhodoquinones, and evolutionary relationships of rhodoquinone producers to bacterial species with various quinone classes. (1995)

The new strains of aerobic chemoorganotrophic rhodoquinone-containing bacteria previously isolated from activated sludge were studied from taxonomic and phylogenetic viewpoints. These strains were Gram- negative, nonmotile coccobacilli, had a strictly respiratory type of metabolism with oxygen or nitrate as the terminal acceptor, produced catalase and oxidase, and contained both ubiquinone-8 and rhodoquinone-8 as major quinones. DNA-DNA reassociation studies revealed that the new strains were highly related to each other at hybridization levels of more than 74%, suggesting the genetic coherency of the isolates as a single species. The 16S rRNA gene from one of the isolates, strain AS-P1, was amplified in vitro and sequenced directly. Sequence comparisons and a distance matrix tree analysis revealed that strain AS-P1 was most closely related to Comamonas testosteroni, a representative of the beta subclass of the Proteobacteria, but the level of sequence similarity between the two appeared to be low enough to warrant different generic allocations. The strains were differentiated from related organisms by a number of phenotypic and chemotaxonomic properties. Thus, we conclude that the isolates should be placed in a new genus and species of the beta subclass of the Proteobacteria, for which we propose the name Brachymonas denitrificans. Evolutionary relationships of rhodoquinone producers to bacterial species with various quinone classes were discussed on the basis of 16S rRNA sequence information.
The inhibition of human platelet function by ganodermic acids (1991)

Human gel-filtered platelets aggregate at greater than 20 microM-ganodermic acid S [lanosta-7,9(11),24-triene-3 beta, 15 alpha-diacetoxy-26-oic acid] [Wang, Chen, Shiao & Wang (1989) Biochim. Biophys. Acta 986, 151-160]. This study showed that platelets at less than 20 microM-ganodermic acid S displayed both concentration- and time-dependent inhibition of function, in which the agent potency in response to inducers was ADP-fibrinogen greater than collagen greater than thrombin. The agent caused a biphasic time-dependent effect on platelet phosphoinositide metabolism. The first phase involved the decrease in the pool size of phosphoinositide by 10-20%. The second phase, in which both the resynthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) and the decrease of [32P]phosphatidic acid occurred, took place after 30 min. Scanning electron microscopy also revealed a time-dependent morphological change in platelets in the presence of the agent. The cells initially became spiculate discs, then swelled to a 'potato-like' morphology at 60 min. Further studies on the time-dependent inhibition of thrombin response revealed that: (1) the percentage inhibition of cell aggregation was comparable with that occurring with an increase of cytosolic free Ca2+ concentration [( Ca2+]i) or the phosphorylation of marker proteins; (2) [32P]Pi-labelled platelets showed the time-dependent inhibition of thrombin-stimulated PIP2 resynthesis as indicated by first-2-min time-course studies of phosphoinositide interconversion; (3) scanning electron microscopy revealed that the aged platelet population showed an increase in the percentage of non-responding cells on prolonged incubation. The results, taken together, enabled one to discuss a possible mechanism for the time-dependent inhibition by ganodermic acid S of platelet response to thrombin.
Akt phosphorylation and stabilization of XIAP: A major mechanism of Akt-induced cell survival at post-mitochondrial level (2004)

4827 Akt negatively regulates apoptotic pathways at a pre-mitochondrial level through phosphorylation and modulation of proteins such as Bad, Forkhead proteins and GSK-3β. Akt has also been shown to protect cell death at a post-mitochondrial level, although its downstream targets have not been well documented. Here, we demonstrate that Akt, including AKT1 and AKT2, interacts with and phosphorylates XIAP at residue serine-87 in vitro and in vivo. Phosphorylation of XIAP by Akt protects XIAP from ubiquitination and degradation in response to cisplatin. Moreover, autoubiquitination of XIAP is also inhibited by Akt. Consistent with this, an XIAP mutant introduced into cells which mimics the Akt-phosphorylated form (i.e., XIAP-S87D) displays reduced ubiquitination and degradation as compared to wild type XIAP. The greater stability of XIAP-S87D in cells translated to increased cell survival after cisplatin treatment. Conversely, a mutant that could not be phosphorylated by Akt (XIAP-S87A) was more rapidly degraded and showed increased cisplatin-induced apoptosis. Further, suppression of XIAP by either siRNA or adenovirus of antisense of XIAP induced programmed cell death and inhibited Akt-stimulated cell survival in ovarian cancer cells. These data identify XIAP as a new downstream target of Akt and a potentially important mediator of Akt’s effect on cell survival.
Stable Dual-Wavelength DFB Fiber Laser With Separate Resonant Cavities and Its Application in Tunable Microwave Generation (2006)

A single-longitudinal-mode dual-wavelength distributed feedback fiber laser with a wavelength spacing of 0.312 nm is proposed and demonstrated. Based on two spatially separated resonant cavities in a single fiber Bragg grating made by a simple method, stable dual-wavelength lasing is established. Then, a 38.67-GHz microwave signal generated by beating the two lasing wavelengths is obtained with a 3-dB bandwidth of ~6 kHz and a frequency drift <5 MHz without any feedback mechanism. As a potential application of this device, a tunable microwave source ranging from 18.67 to 58.67 GHz (with a small discontinuity) is proposed and partially demonstrated
3D Shape Matching with 3D Shape Contexts (2003)

Content based 3D shape retrieval for broad domains like the World Wide Web has recently gained considerable attention in Computer Graphics community. One of the main challenges in this context is the mapping of 3D objects into compact canonical representations referred to as descriptors or feature vector, which serve as search keys during the retrieval process. The descriptors should have certain desirable properties like invariance under scaling, rotation and translation as well as a descriptive power providing a basis for similarity measure between threedimensional objects which is close to the human notion of resemblance. In this paper we introduce an enhanced 3D approach of the recently introduced 2D Shape Contexts that can be used for measuring 3d shape similarity as fast, intuitive and powerful similarity model for 3D objects. The Shape Context at a point captures the distribution over relative positions of other shape points and thus summarizes global shape in a rich, local descriptor. Shape Contexts greatly simplify recovery of correspondences between points of two given shapes. Moreover, the Shape Context leads to a robust score for measuring shape similarity, once shapes are aligned.
Anti-C1q autoantibodies in murine lupus nephritis (2003)

Autoantibodies against C1q can be found in the circulation of patients with several autoimmune diseases including systemic lupus erythematosus (SLE). In SLE there is an association between the occurrence of these antibodies and renal involvement. How anti-C1q autoantibodies contribute to renal disease is currently unknown. Cohorts of MRL-lpr mice, which are known to develop age-dependent SLE-like disease, were used to study the relationship between levels of anti-C1q autoantibodies and renal disease. We collected serum, urine and renal tissue and analysed autoantibodies, complement levels and renal deposition as well as renal function. At 2 months of age all mice already had elevated levels of anti-C1q autoantibodies, and elution of kidneys revealed the presence of these antibodies in renal immune deposits in MRL-lpr mice and not in control MRL+/+ mice. In conclusion, anti-C1q antibodies are already present in serum and immune deposits of the kidney early in life and therefore can play a role in nephritis during experimental SLE-like disease in mice.
The highly irregular firing of cortical cells is inconsistent with temporal integration of random EPSPs (1993)

How random is the discharge pattern of cortical neurons? We examined recordings from primary visual cortex (V1; Knierim and Van Essen, 1992) and extrastriate cortex (MT; Newsome et al., 1989a) of awake, behaving macaque monkey and compared them to analytical predictions. For nonbursting cells firing at sustained rates up to 300 Hz, we evaluated two indices of firing variability: the ratio of the variance to the mean for the number of action potentials evoked by a constant stimulus, and the rate-normalized coefficient of variation (Cv) of the interspike interval distribution. Firing in virtually all V1 and MT neurons was nearly consistent with a completely random process (e.g., Cv approximately 1). We tried to model this high variability by small, independent, and random EPSPs converging onto a leaky integrate-and-fire neuron (Knight, 1972). Both this and related models predicted very low firing variability (Cv << 1) for realistic EPSP depolarizations and membrane time constants. We also simulated a biophysically very detailed compartmental model of an anatomically reconstructed and physiologically characterized layer V cat pyramidal cell (Douglas et al., 1991) with passive dendrites and active soma. If independent, excitatory synaptic input fired the model cell at the high rates observed in monkey, the Cv and the variability in the number of spikes were both very low, in agreement with the integrate-and-fire models but in strong disagreement with the majority of our monkey data. The simulated cell only produced highly variable firing when Hodgkin-Huxley-like currents (INa and very strong IDR) were placed on distal dendrites. Now the simulated neuron acted more as a millisecond-resolution detector of dendritic spike coincidences than as a temporal integrator. We argue that neurons that act as temporal integrators over many synaptic inputs must fire very regularly. Only in the presence of either fast and strong dendritic nonlinearities or strong synchronization among individual synaptic events will the degree of predicted variability approach that of real cortical neurons.
Inhibition of serum phospholipase-A<sub>2</sub>in acute pancreatitis by pharmacological agents<i>in vitro</i> (1997)

Phospholipase-A2 has been suggested as having a role in the pathophysiology of acute pancreatitis. The inhibition of phospholipase-A2 was studied in vitro using 17 pharmacological agents in the search for a specific therapy for acute pancreatitis. The inhibitory effect was tested using an isotopic assay system with 2-palmitoyl-(1-14C)-labelled dipalmitoyl phosphatidylcholine as a substrate and 10 microliters of serum from patients with acute necrotizing pancreatitis as an enzyme source. Among all agents tested, anti-inflammatory drugs inhibited enzyme activity most significantly: indomethacin (9.0 x 10(-3) mol l-1) decreased the phospholipase-A2 activity to one- tenth. The weak inhibitory effect could also be demonstrated using a lower concentration of 2 x 10(-5) mol l-1, which can be achieved after intravenous administration of 50 mg of this drug. The other drugs inhibited the enzyme activity at concentrations higher than those achieved after intravenous injections in clinical use. Diclofenac (3.1 x 10(-2) mol l-1) reduced the phospholipase-A2 activity by 93%, ketoprofen (2.0 x 10(-2) mol l-1) or chlorpromazine (1.4 x 10(-2) mol l-1) by 90%, tobramycin (1.7 x 10(-2) mol l-1) by 84%, doxycycline (9.0 x 10(-3) mol l-1) by 61%, dexamethasone (1.7 x 10(-3) mol l-1) by 62%, methylprednisolone (3.8 x 10(-2) mol l-1) by 50%, and pindolol (1.0 x 10(-4) mol l-1) by 59%. A weak inhibition of phospholipase-A2 activity was demonstrated by betamethasone, bupivacaine, digoxin, hydrocortisone, lidocaine, metoprolol, propranolol, and vancomycin. Indomethacin proved the most potent of the tested agents in inhibiting phospholipase-A2 activity in serum from patients with acute pancreatitis and should be further studied in vivo.
Exposure of KS483 Cells to Estrogen Enhances Osteogenesis and Inhibits Adipogenesis (2002)

Osteoblasts and adipocytes arise from a common progenitor cell in bone marrow. Whether estrogen directly regulates the progenitor cells differentiating into osteoblasts or adipocytes remains unknown. Using a mouse clonal cell line KS483 cultured in charcoal-stripped fetal bovine serum (FBS), we showed that 17beta-estradiol (E2) stimulates the differentiation of progenitor cells into osteoblasts and concurrently inhibits adipocyte formation in an estrogen receptor (ER)-dependent way. E2 increased alkaline phosphate (ALP) activity and nodule formation and stimulated messenger RNA (mRNA) expression of core-binding factor alpha-1 (Cbfa1), parathyroid hormone/parathyroid hormone-related protein receptors (PTH/PTHrP-Rs), and osteocalcin. In contrast, E2 decreased adipocyte numbers and down-regulated mRNA expression of peroxisome proliferator-activated receptor-gamma (PPARgamma)2, adipocyte protein 2 (aP2), and lipoprotein lipase (LPL). Furthermore, the reciprocal control of osteoblast and adipocyte differentiation by E2 was observed also in the presence of the adipogenic mixture of isobutylmethylxanthine, dexamethasone, and insulin. Immunohistochemical staining showed that ERalpha and ERbeta were present in osteoblasts and adipocytes. A new mouse splice variant ERbeta2 was identified, which differed in two amino acid residues from the rat isoform. E2 down-regulated mRNA expression of ERalpha, ERbeta1, and ERbeta2. The effects of E2 are not restricted to the KS483 cell line because similar results were obtained in mouse bone marrow cell cultures. Our results indicate that estrogen, in addition to stimulation of osteogenesis, inhibits adipogenesis, which might explain the clinical observations that estrogen-deficiency leads to an increase in adipocytes.
The Effect of Altering the Size of Poly C on the Toxicity and Antigenicity of Poly I:C (1972)

SummaryAppropriate reduction in size of poly C by degradation with ribonuclease prior to complexing with poly I effected marked reduction in toxicity for mice and antigenicity for rabbits of poly I:C without detectable reduction in in vivo or in vitro protection against viral infection. There was slight reduction in interferon-inducing capacity for rabbits. Such procedure adds another possible means for increasing the safety of poly I:C in eventual clinical application.The authors are indebted to Mary-Ellen Davies, Helen Perry, Carolyn Saydah and Carol Bonoma for excellent technical assistance.
Depth map quality metric for three-dimensional video (2009)

In this paper, we propose a depth map quality metric for three-dimensional videos which include stereoscopic videos and autostereoscopic videos. Recently, a number of researches have been done to figure out the relationship of perceptual quality and video impairment caused by various compression methods. However, we consider non-compression issues which are induced during acquisition and displaying. For instance, using multiple cameras structure may cause impairment such as misalignment. We demonstrate that the depth map can be a useful tool to find out the implied impairments. The proposed quality metrics using depth map are depth range, vertical misalignment, temporal consistency. The depth map is acquired by solving corresponding problems from stereoscopic video, widely known as disparity estimation. After disparity estimation, the proposed metrics are calculated and integrated into one value which indicates estimated visual fatigue based on the results of subjective assessment. We measure the correlation between objective quality metrics and subjective quality results to validate our metrics.
Advanced High-Voltage 4H-SiC Schottky Rectifiers (2008)

This paper presents advanced 4H-SiC high-voltage Schottky rectifiers with improved performance when compared to conventional 4H-SiC Schottky rectifiers. Two types of 4H-SiC junction barrier Schottky (JBS) rectifiers have been explored. These rectifiers offer Schottky-like ON-state and fast switching characteristics, while their OFF-state characteristics have a low leakage current similar to that of the PiN junction rectifier. Planar 4H-SiC JBS rectifiers, with more than 1-kV blocking capability and orders of magnitude lower reverse leakage current than that of conventional SiC Schottky rectifiers, have been demonstrated. In addition, a novel device structure, called lateral channel JBS rectifier, was designed and experimentally demonstrated in 4H-SiC with up to 1.5-kV blocking capability and pinlike reverse characteristics.
Anticancer Effects of 15d-Prostaglandin-J2 in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC (2011)

15-Deoxy-delta-12,14-prostaglandin-J(2) (15d-PGJ(2)), an arachidonic metabolite and a natural PPARγ agonist, is known to induce apoptosis in tumor cells. In this study, we investigated new therapeutic potentials of 15d-PGJ(2) by determining its anticancer effects in wild-type and doxorubicin-resistant ovarian carcinoma cells. Despite high expression of resistance-inducing genes like MDR1, Bcl2 and Bcl-xl, 15d-PGJ(2) strongly induced apoptosis in doxorubicin-resistant (A2780/AD) cells similar to the wild-type (A2780). This was found to be related to caspase-3/7- and NF-κB pathways but not to its PPARγ agonistic activity. 15d-PGJ(2) also was able to reduce the doxorubicin resistance of A2780/AD cells at low doses as confirmed by the inhibition of gene expression of MDR1 (p-glycoprotein) and SIRT1 (a drug senescence gene). We also investigated effects of 15d-PGJ(2) on cell migration and transformation using a wound-healing assay and morphological analyses, respectively. We found that 15d-PGJ(2) inhibited migration most likely due to NF-κB inhibition and induced transformation of the round-shape A2780/AD cells into elongated epithelial cells due to HDAC1 inhibition. Using a 15d-PGJ(2) analog, we found the mechanism of action of these new activities of 15d-PGJ(2) on SIRT1 and HDAC1 gene expressions and enzyme activities. In conclusion, the present study demonstrates that 15d-PGJ(2) has a high therapeutic potential to kill drug-resistant tumor cells and, the newly described inhibitory effects of this cyclo-oxygenase product on SIRT1 and HDAC will provide new opportunities for cancer therapeutics.
Fast parallel algorithm for the single link heuristics of hierarchical clustering (2003)

A fast parallel algorithm of single link heuristics of hierarchical clustering is presented. Its time processor product is optimal and the parallel time is the square of the logarithm. The algorithm is based on computing a minimum spanning tree which can be done in O(log/sup 2/ n) time using O(n/sup 2//log/sup n/) processors. The main gap to be filled is to compute a hierarchical clustering tree (dendrogram) from a minimum spanning tree. The author proves that this can be done in O(log n) time using O(n) processors. Therefore, the overall time-processor product of O(n/sup 2/) is optimal.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Recombinant Human Erythropoietin (rHuEPO) for the Treatment of the Anemia of Cancer (1996)

Abstract Advanced cancer is frequently associated with a significant anemia that may be due to the disease itself or the effect of concomitantly administered chemotherapeutic agents. In a series of double-blind, placebo-controlled trials, three populations of anemic cancer patients were randomized to rHuEPO or placebo. The three populations were: A) patients not receiving concomitant chemotherapy, B) patients receiving chemotherapeutic regimens which did not contain cisplatin, and C) patients receiving chemotherapeutic regimens which contained cisplatin. In the no-chemotherapy trials, patients were treated with rHuEPO (100 U/kg) or placebo s.c. three times a week for up to eight weeks. In the two types of chemotherapy trials, patients were treated with rHuEPO (150 U/kg) or placebo SC three times a week for 12 weeks. A total of 413 patients were enrolled in these trials (124 in the no-chemotherapy group, 157 in the no-cisplatin chemotherapy group and 132 in the cisplatin chemotherapy group). In each trial, patients randomized to rHuEPO had a significantly greater (p &lt; .004) increase in hematocrit than placebo-treated patients. In the two types of chemotherapy trials combined, utilizing an rHuEPO dose of 150 U/kg, rHuEPO-treated patients had significantly lower (p ≤ .009) transfusion requirements (percentage of patients transfused and mean units of blood transfused per patient) than placebo-treated patients during months two and three, but not during month one. Quality-of-life parameters measured on a 100 mm visual analog scale significantly improved (p&lt;.05) in rHuEPO-treated patients whose hematocrit increased ≥6 percentage points, compared to corresponding quality-of-life changes in placebo-treated patients. rHuEPO was well tolerated compared to placebo. The above results suggest that rHuEPO may be a useful agent to palliate the morbid consequences of the anemia that is often found in association with advanced cancer.
The Pathogenesis of Atherosclerosis (1976)

The Response-to-Injury HypothesisThe response-to-injury hypothesis dates back to the pioneering work of Virchow.120 Since then, it has been modified and extended by many investigators, including Duguid,121 French20 and Mustard and Packham,122 who play a particularly important part in its development. The basis for the hypothesis lies in the similarity between atherosclerosis and the response of arteries to experimental injury, described in the first part of this review. A modification of the hypothesis that takes into account many aspects of the behavior of arterial cells noted in that section is currently being studied in our laboratory. . . .