gebhart/patrepeval huggingface dataset:
CHARACTERIZATION OF CULTURED BLADDER SMOOTH MUSCLE CELLS: ASSESSMENT OF IN VITRO CONTRACTILITY (1999)

In vitro cultured bladder SMC demonstrate loss of contractile response to normal in vivo pharmacologic agonists. Both human and rat bladder SMC can be distinguished in vitro from fibroblasts based upon their lack of contractile response to calcium- ionophore. These results demonstrate the ability to further characterize cultured bladder SMC with in vitro contractility. Further characterization is essential if we are to advance our understanding of the clinical applicability of in vitro studies utilizing cultured bladder SMC.
<i>Claus Schuppenhauer, Der Kampf um den Reim in der deutschen Literatur des 18. Jahrhunderts</i> (1973)

(1973). Claus Schuppenhauer, Der Kampf um den Reim in der deutschen Literatur des 18. Jahrhunderts. The Germanic Review: Literature, Culture, Theory: Vol. 48, No. 1, pp. 73-76.
Workload Characterization of 3D Games (2006)

The rapid pace of change in 3D game technology makes workload characterization necessary for every game generation. Comparing to CPU characterization, far less quantitative information about games is available. This paper focuses on analyzing a set of modern 3D games at the API call level and at the micro architectural level using the Attila simulator. In addition to common geometry metrics and, in order to understand tradeoffs in modern GPUs, the microarchitectural level metrics allow us to analyze performance key characteristics such as the balance between texture and ALU instructions in fragment programs, dynamic anisotropic ratios, vertex, z-stencil, color and texture cache performance
Analog-to-digital converter technology comparison (2005)

Analog-to-digital converters are ubiquitous, critical components of signal processing systems. This presentation surveys the state-of-the-art for ADCs and includes both experimental converters and commercially available parts. The shape of the distribution on a resolution vs. sampling rate graph provides insight into ADC performance limitations. For sampling frequencies ranging from /spl sim/0.5 MSPS to /spl sim/4 GSPS, resolution falls off by /spl sim/1 bit for every doubling of the sampling rate. This effect can be related to aperture jitter. For ADCs operating at /spl ges/4 GSPS, the speed of the device technology is a limiting factor. In order to push back these limits, many ADC architectures have been proposed and implemented.
Hypercoagulable states: an algorithmic approach to laboratory testing and update on monitoring of direct oral anticoagulants (2014)

Hypercoagulability can result from a variety of inherited and, more commonly, acquired conditions. Testing for the underlying cause of thrombosis in a patient is complicated both by the number and variety of clinical conditions that can cause hypercoagulability as well as the many potential assay interferences. Using an algorithmic approach to hypercoagulability testing provides the ability to tailor assay selection to the clinical scenario. It also reduces the number of unnecessary tests performed, saving cost and time, and preventing potential false results. New oral anticoagulants are powerful tools for managing hypercoagulable patients; however, their use introduces new challenges in terms of test interpretation and therapeutic monitoring. The coagulation laboratory plays an essential role in testing for and treating hypercoagulable states. The input of laboratory professionals is necessary to guide appropriate testing and synthesize interpretation of results.
SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function (2000)

Notch proteins are transmembrane receptors that mediate intercell communication and direct individual cell fate decisions. The activated intracellular form of Notch, NotchIC, translocates to the nucleus, where it targets the DNA binding protein CBF1. CBF1 mediates transcriptional repression through the recruitment of an SMRT-histone deacetylase-containing corepressor complex. We have examined the mechanism whereby NotchIC overcomes CBF1-mediated transcriptional repression. We identified SKIP (Ski-interacting protein) as a CBF1 binding protein in a yeast two-hybrid screen. Both CBF1 and SKIP are highly conserved evolutionarily, and the SKIP-CBF1 interaction is also conserved in assays using the Caenorhabditis elegans and Drosophila melanogaster SKIP homologs. Protein-protein interaction assays demonstrated interaction between SKIP and the corepressor SMRT. More surprisingly, SKIP also interacted with NotchIC. The SMRT and NotchIC interactions were mutually exclusive. In competition binding experiments SMRT displaced NotchIC from CBF1 and from SKIP. Contact with SKIP is required for biological activity of NotchIC. A mutation in the fourth ankyrin repeat that abolished Notch signal transduction did not affect interaction with CBF1 but abolished interaction with SKIP. Further, NotchIC was unable to block muscle cell differentiation in myoblasts expressing antisense SKIP. The results suggest a model in which NotchIC activates responsive promoters by competing with the SMRT-corepressor complex for contacts on both CBF1 and SKIP.
Response and adaptation of beagle dogs to hypergravity. (1975)

Eight male Beagle dogs, five months old, were centrifuged for three months at progressively increasing loads ranging from 1.5 g to 2.5 g on a 7.9 m radius centrifuge. Dogs were maintained on the centrifuge, which was run almost continuously, by employing a special designed automated waste disposal and life support system. Heart rate and deep body temperature were monitored continuously by implant biotelemetry. Initially, centrifuged dogs showed transient decreases in heart rate and body temperature along with changes in their diurnal rhythm patterns. Compared with normal gravity controls, exposed dogs showed a slower growth rate and a reduced amount of body fat. Blood protein, total lipids, cholesterol, calcium, packed cell volume, red blood cell count, and hemoglobin were also decreased significantly. Absolute weights of the leg bones of centrifuged dogs were significantly greater than controls. Photon absorptiometry revealed significant density increases in selective regions of the femur and humerus of centrifuged dogs. In spite of the various changes noted, results from this and other studies affirm the view that dogs can tolerate and adapt to sustained loads as high as 2.5 g without serious impairment of their body structure and function.
Synthesis and Tastes of Some Flavanone- and Dihydrochalcone Glycosides (1975)

Naringenin-7-β-maltoside (I), -7-β-cellobioside (II), -7-β-lactoside (III), -7-β-melibioside (IV) and hesperetin-7-β-[d-galactosyl (α 1→2) d-glucoside] (V), -7-β-[d-glucosyl (β 1→2) d-galactoside] (VI) and -7-β-melibioside (VII) were prepared by the coupling of naringenin or hesperetin with the acetobromo derivatives of appropriate disaccharides followed by removal of the protecting acetyl groups. Narigenindihydrochalcone-4′-β-kojibioside (VIII), -4′-β-maltoside (IX), -4′-β-cellobioside (X), -4′-β-lactoside (XI), -4′-β-melibioside (XII) and hesperetindihydrochalcone-4′-β-[d-galactosyl (α 1→2) d-glucoside] (XIII), -4′-β-sophoroside (XIV) and -4′-β-melibioside (XV) were synthesized by catalytic reduction of the appropriate flavanone-7-β-glycosides. Among the compounds synthesized, IX and X are 4 and 8 times as sweet as sucrose on the basis of percentage concentration, respectively, but the others are tasteless.
Direct Somatic Embryogenesis, Plant Regeneration and Evaluation of Plants Obtained from Mesophyll Protoplasts of Brassica juncea) (1989)

Isolated mesophyll protoplasts of Brassica Juncea directly developed into somatic embryos on medium supplemented with an auxin and a cytokinin. The somatic embryos germinated into plantlets when medium was supplemented with GA2, and ABA. The plantlets were transferred to the field and the second generation (P2) was evaluated for various agronomic characters. Some of the P2 lines showed variation in height and time required for flowering. Only two out of 53 lines were comparable to the control in grain yield
[Adjuvant effects of glucan on antibody formation in swine]. (1992)

The effect of glucan, a yeast product isolated from Saccharomyces cerevisiae, on the antibody production to the bovine serum albumin and tetanus toxoid was investigated in miniature pigs. A significant stimulation of the immune response to both antigens differing in their thymus dependency was demonstrated during three weeks after the glucan application, by ELISA, in comparison to the untreated controls.
A diverse set of microRNAs and microRNA-like small RNAs in developing rice grains (2008)

Endogenous small RNAs, including microRNAs (miRNAs) and short-interfering RNAs (siRNAs), function as post-transcriptional or transcriptional regulators in plants. miRNA function is essential for normal plant development and therefore is likely to be important in the growth of the rice grain. To investigate the roles of miRNAs in rice grain development, we carried out deep sequencing of the small RNA populations of rice grains at two developmental stages. In a data set of approximately 5.5 million sequences, we found representatives of all 20 conserved plant miRNA families. We used an approach based on the presence of miRNA and miRNA* sequences to identify 39 novel, nonconserved rice miRNA families expressed in grains. Cleavage of predicted target mRNAs was confirmed for a number of the new miRNAs. We identified a putative mirtron, indicating that plants may also use spliced introns as a source of miRNAs. We also identified a miRNA-like long hairpin that generates phased 21 nt small RNAs, strongly expressed in developing grains, and show that these small RNAs act in trans to cleave target mRNAs. Comparison of the population of miRNAs and miRNA-like siRNAs in grains to those in other parts of the rice plant reveals that many are expressed in an organ-specific manner.
Dual-Level Metal (DLM) method for fabricating thin film wiring structures (2002)

This paper describes a fabrication method for multilevel, thin film wiring in which each wiring level and a solid via or stud to the level below, are formed as one integral unit. The processing scheme described makes use of a photosensitive polyimide (PSPI) for defining the wiring channels and a non-photosensitive polyimide for the vias. The via opening in the non-photosensitive polyimide is formed by laser ablation while the wiring channels are formed in the PSPI layer by photolithography. The via hole and the channels in the PSPI are filled in the same metallization step consisting of electroplating copper over a sputtered seed layer. The wiring pattern is finally delineated when a planarization step removes the excess plated copper. This processing method, which we refer to as the Dual Layer Metallization (DLM) method, is found to be very economical, in terms of the number of process steps involved, for forming multilevel, polyimide-copper wiring structures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An Adaptive Controller for Closed-Loop Management of Blood Pressure in Seriously Ill Patients (1987)

An adaptive control strategy is described which has been used for closed-loop computer control of blood pressure in patients in the Intensive Care and Cardiac Surgical Units of the Royal Melbourne Hospital. The initial development and testing of the control algorithm was done by simulation using computer facilities in the Intensive Care Unit. Adaptation to patient variability utilizes a model reference strategy. Control is based on readings of mean arterial pressure obtained from a standard patient monitor unit and implemented by controlling the infusion rate of a volumetric infusion pump. Patient data are displayed graphically on a VDU during control and stored on disk for subsequent postcontrol display and analysis by the medical staff. Clinical trials have indicated that the system is robust and can maintain effective control following sudden large variations in the patient's blood pressure.
Cell-Permeating <i>α</i> -Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells (2007)

Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are components of the tricarboxylic acid (TCA) cycle and tumor suppressors. Loss of SDH or FH induces pseudohypoxia, a major tumor-supporting event, which is the activation of hypoxia-inducible factor (HIF) under normoxia. In SDH- or FH-deficient cells, HIF activation is due to HIF1alpha stabilization by succinate or fumarate, respectively, either of which, when in excess, inhibits HIFalpha prolyl hydroxylase (PHD). To reactivate PHD, we focused on its substrate, alpha-ketoglutarate. We designed and synthesized cell-permeating alpha-ketoglutarate derivatives, which build up rapidly and preferentially in cells with a dysfunctional TCA cycle. This study shows that succinate- or fumarate-mediated inhibition of PHD is competitive and is reversed by pharmacologically elevating intracellular alpha-ketoglutarate. Introduction of alpha-ketoglutarate derivatives restores normal PHD activity and HIF1alpha levels to SDH-suppressed cells, indicating new therapy possibilities for the cancers associated with TCA cycle dysfunction.
Adjust ELF Format for Multi-core Architecture (2009)

There are two problems emerged while multi-core platform become popular in daily life, no matter for high end or low end. The first is how to fully utilize computing resource of these cores without requirement of large modifications of current software design model. The second is about dividing a piece of serial program into parallel program. However, the latter is the responsibility of compiler, which involves complex analysis of logical relationship and data dependency hidden in source code. Assuming a powerful compiler, we propose a new ELF format with multiple text sections each of which corresponds to a piece of logically separated code that could be loaded into a single thread. Similar research has been done on this, but they need a compiler with multiple thread library support which may lead to an overstaffed compiler. We assign this work to program loader and thus reduce design complexity of compiler.
Group-Sparse Signal Denoising: Non-Convex Regularization, Convex Optimization (2014)

Convex optimization with sparsity-promoting convex regularization is a standard approach for estimating sparse signals in noise. In order to promote sparsity more strongly than convex regularization, it is also standard practice to employ non-convex optimization. In this paper, we take a third approach. We utilize a non-convex regularization term chosen such that the total cost function (consisting of data consistency and regularization terms) is convex. Therefore, sparsity is more strongly promoted than in the standard convex formulation, but without sacrificing the attractive aspects of convex optimization (unique minimum, robust algorithms, etc.). We use this idea to improve the recently developed ‘overlapping group shrinkage’ (OGS) algorithm for the denoising of group-sparse signals. The algorithm is applied to the problem of speech enhancement with favorable results in terms of both SNR and perceptual quality.
Robust and efficient data management for a distributed hash table (2003)

This thesis presents a new design and implementation of the DHash distributed hash table based on erasure encoding. This design is both more robust and more efficient than the previous replication-based implementation [15]. DHash uses erasure coding to store each block as a set of fragments. Erasure coding increases availability while saving storage and communication costs compared to a replication based design. DHash combines Chord’s synthetic coordinates with the the set of fragments to implement server selection on block retrieval. DHash enhances robustness by implementing efficient fragment maintenance protocols. These protocols restore missing or misplaced fragments caused by hosts joining and leaving the system.
Robust Nuclear Quadrupole Resonance Signal Detection Allowing for Amplitude Uncertainties (2008)

Nuclear quadrupole resonance (NQR) is a solid-state radio frequency spectroscopic technique that can be used to detect compounds which contain quadrupolar nuclei, a requirement fulfilled by many high explosives and narcotics. Unfortunately, the low signal-to-noise ratio (SNR) of the observed signals currently inhibits the widespread use of the technique, thus highlighting the need for intelligent processing algorithms. In earlier work, we proposed a set of maximum likelihood-based algorithms enabling detection of even very weak NQR signals. These algorithms are based on derived realistic NQR data models, assuming that the (complex) amplitudes of the NQR signal components are known to within a multiplicative constant. However, these amplitudes, which are obtained from experimental measurements, are typically prone to some level of uncertainty. For such cases, these algorithms will experience a loss in performance. Herein, we develop a set of robust algorithms, allowing for uncertainties in the assumed amplitudes, showing that these offer a significant performance gain over the current state-of-the art techniques.
Formation and manipulation of ferrofluid droplets at a microfluidic<i>T</i>-junction (2010)

This paper reports the formation and manipulation of ferrofluid droplets at a microfluidic T-junction in the presence of a permanent magnetic field. A small circular permanent magnet with a diameter of 3 mm is used to controls the size of the ferrofluid droplets within a microfluidic device. In the absence of a magnetic field, the size of the ferrofluid droplets decreases linearly with the increase of the flow rate of the continuous phase. In the presence of a magnetic field, the size of the droplets depends on the magnetic field strength, magnetic field gradient and the magnetization of the ferrofluid. The magnetic field strength is adjusted in our experiment by the location of the magnet. The induced attractive magnetic force affects the droplet formation process leading to the change in size of the formed droplets. Experimental observation also shows that the relative change in the size of the droplet depends on the flow rate of the continuous phase. Furthermore, the paper compares the evolving shape of the ferrofluid droplet during the formation process with and without the magnetic field.
Fuzzy Set Methods in Pattern Recognition. (1988)

Dealing with uncertainty is a common problem in pattern recognition. Rarely do object descriptions from different classes fall into totally disjoint regions of feature space. This uncertainty in class definition can be handled in several ways. In this paper we present several approaches to the incorporation of fuzzy set information into pattern recognition. We then introduce a new technique based on the fuzzy integral which combines objective evidence with the importance of that feature set for recognition purposes. In effect, the fuzzy integral performs a local feature selection, in that it attempts to use the strongest measurements first in the object classification. Algorithm performance is illustrated on real and synthetic data sets.
Home Care Prophecies and Predictions, Part I (1987)

Elsie Griffith, MN, RN, is Chief Executive Officer, Visiting Nurse Service of New York, New York City
Risk of Ovarian Cancer in Relation to Estrogen and Progestin Dose and Use Characteristics of Oral Contraceptives (2000)

Although past studies have shown that oral contraceptives with 50 microg or more of estrogen reduce the risk of ovarian cancer, it is not clear whether newer, lower-dose formulations do as well. We conducted a population-based, case-control study in the Delaware Valley to assess the impact of dose of oral contraception on risk of ovarian cancer. Cases aged 20-69 years with a diagnosis of epithelial ovarian cancer ascertained between May 1994 and July 1999 (n = 767) were compared with community controls (n = 1,367). Compared with never users, the adjusted risk of ovarian cancer was reduced by 40% for oral contraceptive users overall, with longer duration of use affording greater protection. The ovarian cancer risk reduction was similar for women who initiated oral contraception before 1972, when high-dose pills dominated the market; between 1972 and 1980; and after 1980, when newer, lower-dose pills dominated. Oral contraceptive estrogen and progestin content were compared for cases and controls after adjustment for current age, number of pregnancies, race, and family history of ovarian cancer. Use of low-estrogen/low-progestin pills afforded an estimated risk reduction (odds ratio = 0.5, 95% confidence interval: 0.3, 0.6) that was identical to that for high-estrogen/high-progestin pills (odds ratio = 0.5, 95% confidence interval: 0.3, 0.7).
Epistemic Network Analysis: A Prototype for 21st-Century Assessment of Learning (2009)

In this article we examine educational assessment in the 21st century. Digital learning environments emphasize learning in action. In such environments, assessments need to focus on performance in context rather than on tests of abstracted and isolated skills and knowledge. Digital learning environments also provide the potential to assess performance in context, because digital tools make it possible to record rich streams of data about learning in progress. But what assessment methods will use this data to measure mastery of complex problem solving—the kind of thinking in action that takes place in digital learning environments? Here we argue that one way to address this challenge is through evidence-centered design1—a framework for developing assessments by systematically linking models of understanding, observable actions, and evaluation rubrics to provide evidence of learning. We examine how evidence-centered design can address the challenge of assessment in new media learning environments by present...
Migration of particles undergoing pressure-driven flow in a circular conduit (1997)

This study focuses on the demixing of neutrally buoyant suspensions of spheres during slow, pressure driven flows in circular conduits. Distributions of the solid fraction of particles, φ, and the suspension velocity, ν, are measured at different lengths from a static in-line mixer. Experiments were conducted over a range of volume average solids fractions, φbulk (0.10⩽φ⩽0.50), and at two different ratios of the particle radius, a, to the radius of the circular conduit, R (a/R=0.0256 and a/R=0.0625). At φbulk⩾0.20, the particles rapidly migrate to the low-shear-rate region in the center of the conduit. This migration results in a blunting of the ν profile, relative to the parabolic profile observed in homogeneous Newtonian fluids. For the flow geometry with the smaller ratio of a/R, the φ profile builds to a sharp maximum or cusp in the center. Particle structures are observed in the experiments with the higher a/R. The entrance lengths for the development of the φ and ν fields, Lφ and Lν, respectively, are strong functions of a/R and φbulk. Lφ and Lν rapidly decrease as φ and a/R increase. Over the range of our data, the ν profiles are observed to develop more rapidly than the φ profiles. The experimental results are compared with fully developed flow predictions from the shear-induced migration (SIM) model and the suspension balance (SB) model. At the smaller a/R, the SIM model more accurately predicts the experimental results. At larger a/R, some qualitative features of the experimental results are better predicted by the SB model, however, neither model provides good quantitative predictions, especially at low φbulk.
Wall Street: A History. (1998)

Journal Article Wall Street: A History. By Charles R. Geisst. (New York: Oxford University Press, 1997. xii, 404 pp. $30.00, ISBN 0-19-511512-0.) Get access Richard R. John Richard R. John University of Illinois at Chicago, Chicago, Illinois Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 85, Issue 3, December 1998, Pages 1107–1108, https://doi.org/10.2307/2567301 Published: 01 December 1998