gebhart/patrepeval huggingface dataset:
Human Myometrial Smooth Muscle Cells are Novel Targets of Direct Regulation by Human Chorionic Gonadotropin1 (1993)

Human myometrium contains receptors for hCG/human LH (hLH). This suggested the possibility that hCG and hLH might regulate human myometrium, which has not previously been considered a direct target of gonadotropin regulation. To investigate such a possibility, highly pure and viable smooth muscle cells were isolated from nonpregnant human myometrium and cultured as monolayers. The cells contained hCG/LH receptor mRNA transcripts and a 50-kDa immunoreactive protein that can bind 125I-hCG in a ligand-specific manner. The presence of hCG during culture resulted in a significant increase of myometrial smooth muscle cell density. The hCG effect was time- and concentration-dependent and was mimicked by hLH but not by human FSH or human FSH or human thyroid-stimulating hormone. Human CG also greatly increased the size of a subpopulation of myometrial smooth muscle cells without affecting their chromosomal ploidy. Antibodies to hCG/LH receptors and hCG blocked hCG effects. Human prolactin and growth hormone, which do not bind to hCG/LH receptors, also increased the myometrial smooth muscle cell density. A protein kinase A inhibitor (H-89) blocked hCG response whereas calphostin (a protein kinase C inhibitor) and lavendustin A (a tyrosine kinase inhibitor) had no effect on hCG response, suggesting that a cAMP/protein kinase A signaling mechanism is involved in hCG action. Eicosanoids from cyclooxygenase and 5-lipoxygenase pathways of arachidonic acid metabolism are probably not involved, because the inhibitors of these enzymes had no effect on hCG response. While progesterone and estradiol could not mimic or modify hCG action, epidermal growth factor did mimic hCG in increasing myometrial smooth muscle cell density.(ABSTRACT TRUNCATED AT 250 WORDS)
Conflicto social y pobreza en la sociedad contemporánea (2011)

Este trabajo en torno al conflicto social surgio en medio del desarrollo de preocupaciones plasmadas en mi tarea como investigadora. En la misma planteo el tema de la pobreza y las representaciones que se tejen en torno a ella tanto por parte de los sujetos pobres, la academia y la prensa escrita.
Por ello el desafio de este articulo tiene como objetivo dar cuenta de una serie de interrogantes de caracter, tanto epistemologico y teorico, que han surgido en el transcurso de la investigacion y que muestra la tension entre las representaciones de los sujetos pobres y las representaciones sociales creadas tanto por el discurso de las teorias sociologicas y como estas se filtran en la prensa escrita.
Synthesis of substituted 2,3-dihydro-4H-1,3-benzoxazin-4-ones and their biological activities (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of substituted 2,3-dihydro-4H-1,3-benzoxazin-4-ones and their biological activitiesJacob Finkelstein and Elliot ChiangCite this: J. Med. Chem. 1968, 11, 5, 1038–1040Publication Date (Print):September 1, 1968Publication History Published online1 May 2002Published inissue 1 September 1968https://pubs.acs.org/doi/10.1021/jm00311a028https://doi.org/10.1021/jm00311a028research-articleACS PublicationsRequest reuse permissionsArticle Views216Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Film Formation in Coatings (2001)

This chapter reviews the complex step of drying in the latex film formation process. Drying modes have a profound effect on drying rates and on the final properties of films, primarily through their influence on film morphology and the distribution of water-soluble species. Three distinct drying modes (acting separately, successively or together) can be defined, namely homogeneous drying (in which the water concentration remains uniform in the sample throughout the drying process), drying normal to the surface (where a dry layer of increasing thickness develops from the air surface of the latex coating; and lateral drying (where dry areas increase in size in a direction parallel to the substrate). Details are given on the current knowledge and understanding of these drying modes. The last section of the chapter considers the main parameters controlling the drying modes, i.e. thickness and geometric effects, the structure and rheology of the dispersion, particle viscoelasticity, and the overall rate of water loss.
Ultraviolet-A1 irradiation decreases clinical disease activity and autoantibodies in patients with systemic lupus erythematosus. (1994)

In this study we assess the effect of ultraviolet radiation, exclusively within the UV-A1 (340-400 nm) range, on disease activity in SLE. Ten SLE patients were irradiated for 15 days, four of them then continuing treatment for 8 months, with low doses (60 kJ/m2/d) of UV-A1 irradiation. They were assessed clinically and serologically before, after 3 weeks, and after 8 months of therapy. Clinical indices of disease decreased in the 10 patients after 3 weeks by 39%; they decreased in the four patients irradiated for 8 months by 70%. Antibodies to Sjögren's syndrome A (anti-SSA) or antinuclear antibodies (ANA) decreased or disappeared in most patients. There were no side effects. In this uncontrolled study, UV-A1 irradiation appears to have been an effective and seemingly innocuous therapeutic modality for patients with SLE, decreasing signs and symptoms of disease, diminishing levels of autoantibodies and increasing in effectiveness with time.
Comparative evaluation of fine- and coarse-grain approaches for software distributed shared memory (1999)

Symmetric multiprocessors (SMPs) connected with low-latency networks provide attractive building blocks for software distributed shared memory systems. Two distinct approaches have been used: the fine-grain approach that instruments application loads and stores to support a small coherence granularity, and the coarse-grain approach based on virtual memory hardware that provides coherence at a page granularity. Fine-grain systems offer a simple migration path for applications developed on hardware multiprocessors by supporting coherence protocols similar to those implemented in hardware. On the other hand, coarse-grain systems can potentially provide higher performance through more optimized protocols and larger transfer granularities, while avoiding instrumentation overheads. Numerous studies have examined each approach individually, but major differences in experimental platforms and applications make comparison of the approaches difficult. This paper presents a detailed comparison of two mature systems, Shasta and Cashmere, representing the fine- and coarse-grain approaches, respectively. Both systems are tuned to run on the same commercially available, state-of-the-art cluster of AlphaServer SMPs connected via a Memory Channel network. As expected, our results show that Shasta provides robust performance for applications tuned for hardware multiprocessors, and can better tolerate fine-grain synchronization. In contrast, Cashmere is highly sensitive to fine-grain synchronization, but provides a performance edge for applications with coarse-grain behavior. Interestingly, we found that the performance gap between the systems can often be bridged by program modifications that address coherence and synchronization granularity. In addition, our study reveals some unexpected results related to the interaction of current compiler technology with application instrumentation, and the ability of SMP-aware protocols to avoid certain performance disadvantages of coarse-grain approaches.
Relations between trainers and line managements: a behavioural science approach (1972)

Trainers themselves, line management and operatives within an organization, as well as external bodies such as Industrial Training Boards, may have differing expectations of the trainer's role and where responsibility for training should lie. It is essential to clarify these attitudes and responsibilities if training is to be carried out effectively.
Glycine Betaine, Carnitine, and Choline Enhance Salinity Tolerance and Prevent the Accumulation of Sodium to a Level Inhibiting Growth of <i>Tetragenococcus halophila</i> (2000)

Natural-abundance (13)C-nuclear magnetic resonance was used to probe the intracellular organic solute content of the moderately halophilic bacterium Tetragenococcus halophila. When grown in complex growth media supplemented or not with NaCl, T. halophila accumulates glycine betaine and carnitine. Unlike other moderate halophiles, T. halophila was not able to produce potent osmoprotectants (such as ectoines and glycine betaine) through de novo synthesis when cultured in defined medium under hyperosmotic constraint. Addition of 2 mM carnitine, glycine betaine, or choline to defined medium improved growth parameters, not only at high salinity (up to 2.5 M NaCl) but also in media lacking NaCl. These compounds were taken up when available in the surrounding medium. The transport activity occurred at low and high salinities and seems to be constitutive. Glycine betaine and carnitine were accumulated by T. halophila in an unmodified form, while exogenously provided choline led to an intracellular accumulation of glycine betaine. This is the first evidence of the existence of a choline-glycine betaine pathway in a lactic acid bacterium. An assay showed that the compatible solutes strikingly repressed the accumulation of glutamate and slightly increased the intracellular potassium level only at high salinity. Interestingly, osmoprotectant-treated cells were able to maintain the intracellular sodium concentration at a relatively constant level (200 to 300 nmol/mg [dry weight]), independent of the NaCl concentration of the medium. In contrast, in the absence of osmoprotectant, the intracellular sodium content increased sharply from 200 to 2,060 nmol/mg (dry weight) when the salinity of the medium was raised from 1 to 2 M. Indeed, the imported compatible solutes play an actual role in regulating the intracellular Na(+) content and confer a much higher salt tolerance to T. halophila.
Model-based classification of radar images (2000)

A Bayesian approach is presented for model-based classification of images with application to synthetic-aperture radar. Posterior probabilities are computed for candidate hypotheses using physical features estimated from sensor data along with features predicted from these hypotheses. The likelihood scoring allows propagation of uncertainty arising in both the sensor data and object models. The Bayesian classification, including the determination of a correspondence between unordered random features, is shown to be tractable, yielding a classification algorithm, a method for estimating error rates, and a tool for evaluating the performance sensitivity. The radar image features used for classification are point locations with an associated vector of physical attributes; the attributed features are adopted from a parametric model of high-frequency radar scattering. With the emergence of wideband sensor technology, these physical features expand interpretation of radar imagery to access the frequency- and aspect-dependent scattering information carried in the image phase.
A Radio-Over-Fiber System With a Novel Scheme for Millimeter-Wave Generation and Wavelength Reuse for Up-Link Connection (2006)

We proposed and experimentally demonstrated a novel scheme to generate an optical millimeter-wave and realized wavelength reuse for uplink connection in a radio-over-fiber system. We employed an optical interleaver to separate the spectrum of the double-sideband signals generated by a single-arm intensity external modulator. The separated first-order sideband modes were used to generate optical millimeter-wave with double RF frequency, while the separated optical carrier was reused for uplink connection
A two-dimensional thin-layer chromatographic procedure for the estimation of plasmalogens (1966)

1. The use of two-dimensional thin-layer chromatography is described that allows the rapid and simultaneous determination of phospholipid classes and their constituent plasmalogens. 2. The method is based on the specific hydrolysis of plasmalogens to (2-acyl) lysophospholipid in the presence of a mercuric chloride spray reagent. 3. The proportion of mercuric chloride-labile phospholipid present in each phospholipid class, calculated on the basis of phosphorus recoveries from the charred chromatogram, was compared with the proportion of long-chain aldehyde and of total lipid phosphorus found in small-scale preparations of each class of phospholipid. 4. The method permits the determination of individual plasmalogens on preparations containing as little as 0.2mug.atom of total lipid phosphorus.
Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats (2011)

The present study was carried out to investigate disposition kinetics of moxifloxacin following single-dose intravenous (i.v.), intramuscular (i.m.), and subcutaneous (s.c.) administration at a dose rate of 5 mg/kg of body weight (b.wt.) in goats. Plasma samples collected after treatments were analyzed for drug concentration using high-performance liquid chromatography (HPLC). After i.v. administration, distribution of the drug was rapid and wide as reflected by high steady-state volume of distribution. Drug elimination was relatively faster with a total body clearance of 0.59 ± 0.03 L/h/kg. Following i.m. injection, the drug has shown the rapid and near-to-complete absorption with bioavailability of 98.20 ± 3.96 per cent. The maximum plasma drug concentration (Cmax) of 1.21 ± 0.04 μg/mL was attained at 1 h (Tmax). The drug was widely distributed as reflected by high apparent volume of distribution. The elimination half-life (t 1/2β ) of the drug was 6.26 ± 0.08 h. Following s.c. administration, the drug was rapidly absorbed (Cmax: 1.16 ± 0.02 μg/mL; tmax: 1 h) and slowly eliminated from the body. The elimination half-life and total body clearance (ClB) were 5.61 ± 0.10 h and 0.60 ± 0.03 L/h/kg, respectively. The bioavailability of moxifloxacin following s.c. administration was 90.44 ± 3.96 per cent.
Pathophysiology and Management of Surgical and Chronic Oral Pain in Dogs and Cats (2006)

Pain involves a myriad of physiochemical responses leading to the perception of an unpleasant sensation arising from tissue damage. An understanding of the terminology and basic neurophysiology involved with the pain process is helpful in preventing and treating discomfort in our patients. A general understanding of the concepts of nociception, peripheral sensitization, and central sensitization will allow decisions to be made on the choices of analgesic agents in each individual patient based upon the type, duration, and severity of the pain. Using preemptive pain management with a multimodal approach provides the most consistent and predictable results. Analgesic protocols should be closely scrutinized on an individual basis with careful patient pain assessment during the postoperative period. Chronic pain mechanisms, particularly significant in cancer pain and stomatitis, require aggressive and perhaps unique approaches to ensure maximum patient comfort.
Evaluation of third trimester uterine artery flow velocity indices in relationship to perinatal complications (2006)

RI and PI as measures of third trimester utero-placental vascular impedance are the best predictors of adverse outcome of IUGR-suspected pregnancies.
Results, results, results: Seeking spaces for learning in a European global learning and stem project (2017)

There is a growing interest in the monitoring and evaluation of Education for Sustainable Development and Global Citizenship (ESD/GC). Development education practitioners highlight tensions between the demands of monitoring and evaluation for reporting purposes and opportunities for learning about practice within funded global learning education projects (Bond, 2012; Fricke, Gathercole with Skinner, 2015). This paper presents a post-project reflection on the monitoring, evaluation and learning (MEL) processes of a three year European Commission (EC) funded project involving non-State actors in formal education systems on development education and global learning in Science, Technology, Engineering and Mathematics (STEM) curricula. The Make the Link project focused on development of engaging materials and teacher training. The authors provide an overview of what was involved in developing a monitoring and evaluation framework that aimed to capture progress against results as defined by the project’s EC logical framework, as well as learning about experiences of global learning and STEM from partners across four country contexts. This reflection contributes to discussion on the theme: How can ESD/GC monitoring, evaluation and research engage meaningfully with practice and vice-versa?
A Ribosomal S-6 Kinase–Mediated Signal to C/EBP-β Is Critical for the Development of Liver Fibrosis (2007)

These data indicate that the RSK-C/EBPbeta phosphorylation pathway is critical for the development of liver fibrosis and suggest a potential therapeutic target.
Synthesis and Characterization of Tetrahedral Ru<sub>3</sub>O Clusters with Intrinsic Framework Chirality:  A Chiral Probe of the Intact Cluster Catalysis Concept (2005)

To bring evidence for or against the hypothesis of catalytic hydrogenation by intact trinuclear arene ruthenium clusters containing an oxo cap, cationic Ru3O clusters with three different arene ligands (intrinsically chiral tetrahedra) have been synthesized as racemic mixtures. By introduction of a chiral auxiliary substituent at one of the three different arene ligands, the separation of the two diastereomers was possible. The chiral Ru3O framework was evidenced by X-ray crystallography, by circular dichroism in the UV and IR regions, and by chiral shift reagents in the NMR spectra. The catalytic hydrogenation of the prochiral substrate methyl 2-acetamidoacrylate using a chiral Ru3O cluster showed no asymmetric induction, suggesting that the catalytically active species is not the intact Ru3O cluster.
Design of Frameworks with Mixed Triangular and Octahedral Building Blocks Exemplified by the Structure of [Zn<sub>4</sub>O(TCA)<sub>2</sub>] Having the Pyrite Topology (2003)

Building blocks, octahedral (basic zinc acetate units) and triangular (tritopic carboxylic acid), are assembled into a metal-organic framework (MOF-150) having the topology of the FeS2 pyrite net (see picture). Two independent nets interpenetrate, forming the first example of a fully catenated structure with mixed coordination, an occurrence that is ascribed to the self-dual property of the pyrite net (TCA=4,4′,4′′-Tricarboxytriphenylamine).
The Preparation and Some Properties of Yttrium, Dysprosium, and Ytterbium Alkoxides (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation and Some Properties of Yttrium, Dysprosium, and Ytterbium AlkoxidesK. S. Mazdiyasni, C. T. Lynch, and J. S. SmithCite this: Inorg. Chem. 1966, 5, 3, 342–346Publication Date (Print):March 1, 1966Publication History Published online1 May 2002Published inissue 1 March 1966https://pubs.acs.org/doi/10.1021/ic50037a003https://doi.org/10.1021/ic50037a003research-articleACS PublicationsRequest reuse permissionsArticle Views492Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electrochemical process for 2,4-D herbicide removal from aqueous solutions using stainless steel 316 and graphite Anodes: optimization using response surface methodology (2018)

In this experimental study, an electrochemical cell (100 cc) equipped with anode electrodes of SS316 and graphite and the cathode electrode of SS316 in parallel form at a distance of 1 cm from each other was used to degradation the 2,4-Diclorophenoxy acetic acid (2,4-D) herbicide. The results showed that the removal efficiency of 2,4-D herbicide in initial concentrations of 50 and 100 mg/L under optimum conditions (pH = 7, electrolysis time = 50 min and current density = 3 mA/cm2) using the graphite anode electrode was 73.5% and 47.76%, respectively; however, using the SS316 electrode, the removal efficiency was 44.23% and 17.65%, respectively. The highest removal of 2,4-D in electrochemical process was 95.87% for herbicide initial concentration of 50 mg/L by graphite anode electrode. Considering the efficiency of 2,4-D removal, the determined coefficients were found to be 0.91–0.93. The amount of energy consumed for SS316 and graphite electrodes was obtained to be 6.308 and 5.99 kWh/m3, respectively. Results revealed that the electrochemical process with graphite anode electrode has an acceptable efficiency in removing the 2,4-D herbicide and can be used as an appropriate pretreatment in treating the wastewater containing the resistant compounds such as phenoxy group herbicides (2,4-D).
Adaptive matched filtering for QRS detection (1988)

The authors have investigated the use of an adaptive filter to whiten the noise in the ECG (electrocardiogram) signal and adjust the matched filter response accordingly. They applied a simple QRS detection strategy to the filtered signal and evaluated the QRS detector with ECG data containing severe motion artifact and muscle noise. Preliminary results indicate that in the presence of severe motion artifact, adaptive matched filtering for QRS detection represents a significant improvement over application of a matched filter with a white noise assumption.< <ETX>></ETX>