gebhart/patrepeval huggingface dataset:
CBF2/DREB1C is a negative regulator of <i>CBF1/DREB1B</i> and <i>CBF3/DREB1A</i> expression and plays a central role in stress tolerance in <i>Arabidopsis</i> (2004)

CBF/DREB1 (C-repeat-binding factor/dehydration responsive element-binding factor 1) genes encode a small family of transcriptional activators that have been described as playing an important role in freezing tolerance and cold acclimation in Arabidopsis. To specify this role, we used a reverse genetic approach and identified a mutant, cbf2, in which the CBF2/DREB1C gene was disrupted. Here, we show that cbf2 plants have higher capacity to tolerate freezing than WT ones before and after cold acclimation and are more tolerant to dehydration and salt stress. All these phenotypes correlate with a stronger and more sustained expression of CBF/DREB1-regulated genes, which results from an increased expression of CBF1/DREB1B and CBF3/DREB1A in the mutant. In addition, we show that the expression of CBF1/DREB1B and CBF3/DREB1A in response to low temperature precedes that of CBF2/DREB1C. These results indicate that CBF2/DREB1C negatively regulates CBF1/DREB1B and CBF3/DREB1A, ensuring that their expression is transient and tightly controlled, which, in turn, guarantees the proper induction of downstream genes and the accurate development of Arabidopsis tolerance to freezing and related stresses.
Glutaraldehyde treatment elicits toxic response compared to decellularization in bovine pericardium (2012)

Glutaraldehyde-stabilized bovine pericardium is used for clinical application since 1970s because of its desirable features such as less immunogenicity and acceptable durability. However, a propensity for calcification is reported on account of glutaraldehyde treatment. In this study, commercially available glutaraldehyde cross-linked bovine pericardium was evaluated for its in vitro cytotoxic effect, macrophage activation, and in vivo toxic response in comparison to decellularized bovine pericardium. Glutaraldehyde-treated bovine pericardium and its extract were observed to be cytotoxic and it also caused significant inflammatory cytokine release from activated macrophages. Significant antibody response, calcification response, necrotic, and inflammatory response were noticed in glutaraldehyde-treated bovine pericardium in comparison to decellularized bovine pericardium in a rat subcutaneous implantation model. Glutaraldehyde-treated bovine pericardium also failed in acute systemic toxicity testing and intracutaneous irritation testing as per ISO 10993. With respect to healing and implant remodeling, total lack of host tissue incorporation and angiogenesis was noticed in glutaraldehyde-treated bovine pericardium compared to excellent host fibroblast incorporation and angiogenesis within the implant in decellularized bovine pericardium. In conclusion, using in vitro and in vivo techniques, this study has demonstrated that glutaraldehyde-treated bovine pericardium elicits toxic response compared to decellularized bovine pericardium which is not congenial for long-term implant performance.
Mixed-Band Wavelet-Chaos-Neural Network Methodology for Epilepsy and Epileptic Seizure Detection (2007)

A novel wavelet-chaos-neural network methodology is presented for classification of electroencephalograms (EEGs) into healthy, ictal, and interictal EEGs. Wavelet analysis is used to decompose the EEG into delta, theta, alpha, beta, and gamma sub-bands. Three parameters are employed for EEG representation: standard deviation (quantifying the signal variance), correlation dimension, and largest Lyapunov exponent (quantifying the non-linear chaotic dynamics of the signal). The classification accuracies of the following techniques are compared: (1) unsupervised k-means clustering; (2) linear and quadratic discriminant analysis; (3) radial basis function neural network; (4) Levenberg-Marquardt backpropagation neural network (LMBPNN). To reduce the computing time and output analysis, the research was performed in two phases: band-specific analysis and mixed-band analysis. In phase two, over 500 different combinations of mixed-band feature spaces consisting of promising parameters from phase one of the research were investigated. It is concluded that all three key components of the wavelet-chaos-neural network methodology are important for improving the EEG classification accuracy. Judicious combinations of parameters and classifiers are needed to accurately discriminate between the three types of EEGs. It was discovered that a particular mixed-band feature space consisting of nine parameters and LMBPNN result in the highest classification accuracy, a high value of 96.7%.
Science: A History 1543-2001 (2002)

"In this book John Gribbin tells the story of the people who made science and the turbulent times they lived in. As well as famous figures such as Copernicus, Darwin and Einstein, there are also the obscure, the eccentric, even the mad. This diverse cast includes, among others, Andreas Vesalius, landmark sixteenth-century anatomist and secret grave-robber; the flamboyant Galileo, accused of heresy for his ideas; the obsessive, competitive Newton, who wrote his rivals out of the history books; Gregor Mendel, the Moravian monk who founded modern genetics; and Louis Agassiz, so determined to prove the existence of ice ages that he marched his colleagues up a mountain to show them the evidence."--BOOK JACKET.
Immobilized pH gradients (IPG) simulator–an additional step in pH gradient engineering: I. Linear pH gradients (1991)

A new computer program, called immobilized pH gradients (IPG) simulator, is proposed for calculating and optimizing any recipe for use in isoelectric focusing in immobilized pH gradients. Unlike our previous monoprotic electrolyte gradient simulation (MGS) and polyelectrolyte gradient simulation (PGS) programs, based on minimizing CV(beta), the present program has a target function the minimization of the quadratic moment around zero of the residuals (mu 2). With this algorithm it is possible to formulate IPG recipes which have deviations from linearity well below 1% of the given pH interval (a limit set with the previous MGS and PGS programs), in fact, as small as 0.1-0.2% (in pH units). The new simulator performs 2-3 times better than the previous ones in the pH 4-10 range, and is absolutely necessary when working outside this range, at extreme pH values, where CV(beta) cannot work against the buffering power of bulk water, thus generating pH recipes with huge deviations from linearity. In the latter cases, mu 2 performs 10 times better than CV(beta). When utilizing strong titrants for extended pH intervals, the "all or none" rule has been discovered: such titrants should always be used in tandem, since omission of one of the two at either the acidic or basic extremes produces strongly distorted pH profiles. Our new, most powerful simulator also contains equations for creating nonlinear gradients, notably: concave and convex exponentials and sigmoidal (see the companion paper: Righetti, P. G. and Tonani, C., Electrophoresis 1991, 12, 1021-1027).
Progestational Activity of 6 -Methyl-17 -Acetoxyprogesterone (1959)

Summary1) 6α-methyl-17α-acetoxyprogesterone is a highly active progestin based on its ability to promote a secretory endometrium and to prevent ovulation in rabbits. 2) Subcutaneously, 6α-methyl-17α-acetoxyprogesterone is 6 to 8 times and orally 60 to 75 times as active as 17α-acetoxyprogesterone in the McPhail assay. The ability of the 6-methyl compound to inhibit ovulation in rabbits is at least 20 times as great as that of progesterone subcutaneously, while 17α-acetoxyprogesterone is 7 times as active as progesterone.
Power Oscillation Damping From VSC–HVDC Connected Offshore Wind Power Plants (2015)

The implementation of power oscillation damping service on offshore wind power plants connected to onshore grids by voltage-source-converter-based high voltage direct current transmission is discussed. Novel design guidelines for damping controllers on voltage-source converters and wind power plant controllers are derived, using phasor diagrams and a test network model and are then verified on a generic power system model. The effect of voltage regulators is analyzed, which is important for selecting the most robust damping strategy. Furthermore, other often disregarded practical implementation aspects regarding real wind power plants are discussed: 1) robustness against control/communication delays; 2) limitations due to mechanical resonances in wind turbine generators; 3) actual capability of wind power plants to provide damping without curtailing production; and 4) power-ramp rate limiters.
Adaptive finite element methods for the solution of inverse problems in optical tomography (2008)

Optical tomography attempts to determine a spatially variable coefficient in the interior of a body from measurements of light fluxes at the boundary. Like in many other applications in biomedical imaging, computing solutions in optical tomography is complicated by the fact that one wants to identify an unknown number of relatively small irregularities in this coefficient at unknown locations, for example corresponding to the presence of tumors. To recover them at the resolution needed in clinical practice, one has to use meshes that, if uniformly fine, would lead to intractably large problems with hundreds of millions of unknowns. Adaptive meshes are therefore an indispensable tool. In this paper, we will describe a framework for the adaptive finite element solution of optical tomography problems. It takes into account all steps starting from the formulation of the problem including constraints on the coefficient, outer Newton-type nonlinear and inner linear iterations, regularization, and in particular the interplay of these algorithms with discretizing the problem on a sequence of adaptively refined meshes. We will demonstrate the efficiency and accuracy of these algorithms on a set of numerical examples of clinical relevance related to locating lymph nodes in tumor diagnosis.
Magnetoswitchable Reactions of DNA Monolayers on Electrodes:  Gating the Processes by Hydrophobic Magnetic Nanoparticles (2005)

Biorecognition and biocatalytic reactions of DNA monolayers, such as hybridization, polymerization, and hydrolytic digestion, were followed in situ by chronocoulometry and Faradaic impedance spectroscopy. Hydrophobic magnetic nanoparticles attracted to, and retracted from, the electrode surface by an external magnetic field were used to activate and inhibit the DNA-monolayer reactions, respectively. The attraction of the magnetic nanoparticles to the electrode surface generated a hydrophobic thin film on the surface that is not permeable for the water-soluble components required for the DNA-monolayer reactions. This results in the inhibition of the DNA-monolayer reactions. The retraction of the magnetic nanoparticles from the surface regenerated the free nucleic acid-functionalized surface that was exposed to the aqueous solution, thus reactivating the DNA-monolayer reactions. The reversible inhibition and activation of the DNA-monolayer reactions upon the cyclic attraction-retraction of the hydrophobic magnetic nanoparticles may be used to synthesize programmed DNA chips.
Titration of Propofol for Anesthetic Induction and Maintenance Guided by the Bispectral Index: Closed-loop versus  Manual Control (2006)

Automatic control of consciousness using the BIS is clinically feasible and outperforms manual control.
ABAP Objects (2007)

The all-new 2nd Edition of this bestselling book covers ABAP development with SAP NetWeaver. Whether you are new to ABAP programming, an experienced developer, or a consultant or project team member: this in-depth reference provides you with comprehensive knowledge of all facets of ABAP technology. Based on ABAP Objects, this 1000+ page book describes all concepts of modern ABAP up to Release 7.0 (including a sneak preview of Release 7.10). Brand new topics found in the new edition include SAP NetWeaver Application Server ABAP, Regular Expressions, Shared Objects, class-based exception handling, assertions, Web Dynpro for ABAP, Object Services, dynamic programming, interface technologies (RFC, ICF, XML), and test tools, among others. Procedural techniques are also covered where necessary.Highlights:SAP NetWeaver Application Server ABAPDevelopment basics: ABAP Workbench, Object Navigator, Class Builder, etc.Basic elements of ABAP ObjectsClassic modularisation and program execution Avoiding erros and error handlingGUI programming: dynpros, lists, selection screens, controls and Web Dynpro Persistent data: DB access, Object Services, file interface, data clustersDynamic programming: field symbols, RTTS, dynamic tokens and procedure calls Data und communication interfaces: RFC, ICF, web services, XML
The renin‐angiotensin system: a link between obesity, inflammation and insulin resistance (2011)

The renin-angiotensin system (RAS) is classically known for its role in regulation of blood pressure, fluid and electrolyte balance. Recently, several local RASs in organs such as brain, heart, pancreas and adipose tissue have also been identified. Evidence from clinical trials suggests that in addition to anti-hypertensive effects, pharmacological inhibition of RAS also provides protection against the development of type-2 diabetes. Moreover, animal models with targeted inactivation of RAS genes exhibit improved insulin sensitivity and are protected from high-fat diet-induced obesity and insulin resistance. Because there is evidence for RAS overactivation in obesity, it is possible that RAS is a link between obesity and insulin resistance. This review summarizes the evidence and mechanistic insights on the associations between RAS, obesity and insulin resistance, with special emphasis on the role of adipose tissue RAS in the pathogenesis of metabolic derangements in obesity.
Peptide-Based Probes for Cancer Imaging (2008)

Receptors for regulatory peptides are overexpressed in a variety of human cancers. They represent the molecular basis for in vivo imaging with radiolabeled peptide probes. Somatostatin-derived tracers, designed to image the sst2-overexpressing neuroendocrine tumors, have enjoyed almost 2 decades of successful development and extensive clinical applications. More recent developments include second- and third-generation somatostatin analogs, with a broader receptor subtype profile or with antagonistic properties. Emerging tracers for other peptide receptors, including cholecystokinin/gastrin and GLP-1 analogs for neuroendocrine tumors, bombesin and neuropeptide-Y analogs for prostate or breast cancers, or Arg-Gly-Asp peptides for neoangiogenesis labeling, are also in current development. Application fields include both SPECT/CT and PET/CT.
Synthesis, molecular structure, and properties of in-phosphaphanes with substituted basal aromatic rings (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, molecular structure, and properties of in-phosphaphanes with substituted basal aromatic ringsAnthony P. West Jr., Natalie Smyth, Christina M. Kraml, Douglas M. Ho, and Robert A. Pascal Jr.Cite this: J. Org. Chem. 1993, 58, 13, 3502–3506Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jo00065a009https://doi.org/10.1021/jo00065a009research-articleACS PublicationsRequest reuse permissionsArticle Views385Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Synthesis of adamantane derivatives. 47. Photochemical synthesis of 4-azahomoadamant-4-enes and further studies on their reactivity in some cycloadditions (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of adamantane derivatives. 47. Photochemical synthesis of 4-azahomoadamant-4-enes and further studies on their reactivity in some cycloadditionsTadashi Sasaki, Shoji Eguchi, and Nao ToiCite this: J. Org. Chem. 1979, 44, 21, 3711–3715Publication Date (Print):October 1, 1979Publication History Published online1 May 2002Published inissue 1 October 1979https://pubs.acs.org/doi/10.1021/jo01335a020https://doi.org/10.1021/jo01335a020research-articleACS PublicationsRequest reuse permissionsArticle Views429Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Next generation auto theft prevention and tracking system for land vehicles (2014)

Automobile theft has been a persisting problem around the world and greater challenge comes from professional thieves. A modern vehicle utilizes remote keyless entry system and immobilizer system as the main weaponry against vehicle theft. But these systems prevent unauthorized access of the vehicle to a certain extent only. Smart gravitational lock is used to prevent the theft by providing the air gesture key from key fob to the vehicle which provides high security to the vehicle. When there is no usage of key fob, then the vehicle is secured by touch screen ignition where the software key gesture is given to the touch screen. GPS and GSM technologies enable the vehicle owners to track and monitor the vehicle at anytime from anywhere. During GPS outage environment, Inertial Navigation Sensor is used that contains 3-axis MEMS magnetometer and accelerometer which inform the vehicle positions to the owner by use of dead reckoning method. To restrict the vehicle movement within a particular area, GPS fencing is used in which fence radius can be programmed in the touch screen display. The integrated motions sensing subsystem is used which measures the vehicles 3-D position and detects if vehicle is moved or tilted, when the threshold level is exceeded. In case of auto theft, fuel supply will be made to cut off slowly by sending the message thereby disabling the vehicle.
Constructing a Fuzzy Rule Based Classification System Using Pattern Discovery (2005)

Pattern discovery (PD), an algorithm which discovers patterns based on a statistical analysis of training data was used to generate rules for a fuzzy rule based classification system (FRBCS). Classification performance of the FRBCS when using rules discovered by the PD algorithm and of the PD algorithm functioning as a classifier applied to a number of linearly and non-linearly separable continuous-valued data sets was compared. The results indicate an increased performance for the FRBCS. The improvement comes through both an increase in correct classifications and a decrease in the error rate in the class distributions studied. The use of trapezoidal shaped input membership functions applied to the input data values allowed vagueness in the input events to be modelled and resulted in a more robust determination of the characteristics of the input data which in turn resulted in more accurate classification. In addition, the standard use of a co-occurrence based weighting of the rules by the FRBCS outperformed the weight-of-evidence based selection and use of input patterns by the PD classifier.
Controlled Release of Nitrate and Sulfate to Enhance Anaerobic Bioremediation of Phenanthrene in Marine Sediments (2005)

Experimental measurements demonstrated that rates of in situ microbial anaerobic biodegradation of phenanthrene in undisturbed marine sediments were enhanced when controlled-release electron acceptors (i.e., nitrate and sulfate (for comparison)) were employed. The experimental method used whole and interval cores injected with radiolabeled 14C-phenanthrene, which were incubated, sacrificed, and processed for 14CO2 recovery to determine degradation rates. Nitrocellulose and CaSO4 were formulated to release the electron acceptors into the sediments at rates consistent with bacterial utilization (i.e., that avoided inhibition observed previously at high soluble nitrate (although not sulfate) concentrations). The controlled-release of both compounds, measured in collateral experiments, enhanced the natural anaerobic phenanthrene biodegradation rates by factors up to 2-3. Biodegradation via sulfate reduction was most rapid in the early stages (24 days) of experiments, consistent with reports that many marine bacteria in submerged sediments are sulfate reducers. In comparison, in longer experiments (after 42 days), the anaerobic biodegradation rates were observed at least as high with the addition of nitrocellulose (over 40% of added phenanthrene recovered as 14CO2). Both nitrate and sulfate reduction was observed during anaerobic incubation, although the presence of nitrate seemed to reduce the sulfate reduction. The studied forms of the controlled-release nitrate and sulfate may provide capping amendments to decontaminate marine harbor sediments.
MODULATION OF AN ELECTRON WAVE BY A LIGHT WAVE (1969)

Electron transmission diffraction patterns of thin monocrystal films are made visible on a nonluminescent target, if the films are illuminated by a 107 Wcm−2 argon laser irradiation. It appears that the 50-keV electrons pick up an oscillation of the light frequency within the crystal film and preserve this oscillation state until they reach the nonluminescent target.