gebhart/patrepeval huggingface dataset:
Design Concepts for Automating Maintenance Instructions (2000)

Abstract : This task was performed under the Technology for Readiness and Sustainment (TRS) contract (F33615-99-D-6001) for the Air Force Research Laboratory (AFRL), Sustainment Logistics Branch (HESS) at Wright-Patterson AFB, OH. The period of research covered the time period 29 January 99 through 29 February 00. The primary objective of this task was to design, develop, and demonstrate a conceptual framework to support the automated validation and verification USAF technical orders (TOs), specifically job guide procedures for maintenance tasks. The outcome of this effort was the definition and demonstration of a conceptual framework for an application or system that could be used by TO authors and Air Force personnel to help validate and verify the safety and accuracy of job guide procedures in maintenance TOs. In addition, this task also produced a core set of critical research and development tasks considered essential to overcoming important barriers to the development of an automated TO validation and verification system or application.
Therapeutic window of dopamine D2/3 receptor occupancy to treat psychosis in Alzheimer’s disease (2017)

See Caravaggio and Graff-Guerrero (doi:10.1093/awx023) for a scientific commentary on this article.Antipsychotic drugs, originally developed to treat schizophrenia, are used to treat psychosis, agitation and aggression in Alzheimer's disease. In the absence of dopamine D2/3 receptor occupancy data to inform antipsychotic prescribing for psychosis in Alzheimer's disease, the mechanisms underpinning antipsychotic efficacy and side effects are poorly understood. This study used a population approach to investigate the relationship between amisulpride blood concentration and central D2/3 occupancy in older people with Alzheimer's disease by combining: (i) pharmacokinetic data (280 venous samples) from a phase I single (50 mg) dose study in healthy older people (n = 20, 65-79 years); (ii) pharmacokinetic, 18F-fallypride D2/3 receptor imaging and clinical outcome data on patients with Alzheimer's disease who were prescribed amisulpride (25-75 mg daily) to treat psychosis as part of an open study (n = 28; 69-92 years; 41 blood samples, five pretreatment scans, 19 post-treatment scans); and (iii) 18F-fallypride imaging of an antipsychotic free Alzheimer's disease control group (n = 10, 78-92 years), to provide additional pretreatment data. Non-linear mixed effects modelling was used to describe pharmacokinetic-occupancy curves in caudate, putamen and thalamus. Model outputs were used to estimate threshold steady state blood concentration and occupancy required to elicit a clinically relevant response (>25% reduction in scores on delusions, hallucinations and agitation domains of the Neuropsychiatric Inventory) and extrapyramidal side effects (Simpson Angus Scale scores > 3). Average steady state blood levels were low (71 ± 30 ng/ml), and associated with high D2/3 occupancies (65 ± 8%, caudate; 67 ± 11%, thalamus; 52 ± 11%, putamen). Antipsychotic clinical response occurred at a threshold concentration of 20 ng/ml and D2/3 occupancies of 43% (caudate), 25% (putamen), 43% (thalamus). Extrapyramidal side effects (n = 7) emerged at a threshold concentration of 60 ng/ml, and D2/3 occupancies of 61% (caudate), 49% (putamen) and 69% (thalamus). This study has established that, as in schizophrenia, there is a therapeutic window of D2/3 receptor occupancy for optimal treatment of psychosis in Alzheimer's disease. We have also shown that occupancies within and beyond this window are achieved at very low amisulpride doses in Alzheimer's disease due to higher than anticipated occupancies for a given blood drug concentration. Our findings support a central pharmacokinetic contribution to antipsychotic sensitivity in Alzheimer's disease and implicate the blood-brain barrier, which controls central drug access. Whether high D2/3 receptor occupancies are primarily accounted for by age- or disease-specific blood-brain barrier disruption is unclear, and this is an important future area of future investigation, as it has implications beyond antipsychotic prescribing.
Inflammatory Cytokines and Fatty Acids Regulate Endothelial Cell Heparanase Expression (2004)

Heparan sulfates, the carbohydrate chains of heparan sulfate proteoglycans, play an important role in basement membrane organization and endothelial barrier function. We explored whether endothelial cells secrete a heparan sulfate degrading heparanase under inflammatory conditions and what pathways were responsible for heparanase expression. Heparanase mRNA and protein by Western blot were induced when cultured endothelial cells were treated with cytokines, oxidized low-density lipoprotein (LDL) or fatty acids. Heparanase protein in the cell media was induced 2-10-fold when cells were treated with tumor necrosis factor alpha (TNFalpha) or interleukin 1beta (IL-1beta). Vascular endothelial growth factor (VEGF), in contrast, decreased heparanase secretion. Inhibitors to nuclear factor-kappaB (NFkappaB), PI3-kinase, MAP kinase, or c-jun kinase (JNK) did not affect TNFalpha-induced heparanase secretion. Interestingly, inhibition of caspase-8 completely abolished heparanase secretion induced by TNFalpha. Fatty acids also induced heparanase, and this required an Sp1 site in the heparanase promoter. Immunohistochemical analyses of cross sections of aorta showed intense staining for heparanase in the endothelium of apoE-null mice but not wild-type mice. Thus, heparanase is an inducible inflammatory gene product that may play an important role in vascular biology.
What does it mean to solve the problem of discrimination in hiring? Social, technical and legal perspectives from the UK on automated hiring systems (2019)

The ability to get and keep a job is a key aspect of participating in society and sustaining livelihoods. Yet the way decisions are made on who is eligible for jobs, and why, are rapidly changing with the advent and growth in uptake of automated hiring systems (AHSs) powered by data-driven tools. Key concerns about such AHSs include the lack of transparency and potential limitation of access to jobs for specific profiles. In relation to the latter, however, several of these AHSs claim to detect and mitigate discriminatory practices against protected groups and promote diversity and inclusion at work. Yet whilst these tools have a growing user-base around the world, such claims of bias mitigation are rarely scrutinised and evaluated, and when done so, have almost exclusively been from a US socio-legal perspective. In this paper, we introduce a perspective outside the US by critically examining how three prominent automated hiring systems (AHSs) in regular use in the UK, HireVue, Pymetrics and Applied, understand and attempt to mitigate bias and discrimination. Using publicly available documents, we describe how their tools are designed, validated and audited for bias, highlighting assumptions and limitations, before situating these in the socio-legal context of the UK. The UK has a very different legal background to the US in terms not only of hiring and equality law, but also in terms of data protection (DP) law. We argue that this might be important for addressing concerns about transparency and could mean a challenge to building bias mitigation into AHSs definitively capable of meeting EU legal standards. This is significant as these AHSs, especially those developed in the US, may obscure rather than improve systemic discrimination in the workplace.
Zur Kenntnis der Farbreaktion von Pyridinbasen mit 1,2‐Epoxiden (1970)

Abstract Die Reaktion von Pyridinbasen mit Epoxiden führt zu farbigen betainartigen, N‐hydroxyäthylierten, partiell hydrierten Oligopyridylen. In einigen Fällen entstehen daneben farblose, definierte Pyridinderivate.
IMPORTANCE OF THE KRALJIC MATRIX AS A STRATEGIC TOOL FOR MODERN PURCHASING (2005)

Too often purchasing is seen as just an improved operational task. Due to this a lot of possibilities to use purchasing as a strategic tool for the organization are simply ignored. This article will show that purchasing could be more. The famous and well known portfolio model of Peter Kraljic will be used as starting position but the core will be to show current developments to turn this model into a strategic tool for purchasing. Also the use for this model in virtual organizations and for extended enterprises will be discussed and we will show that these organizations will profit from using this model for making decisions concerning make or buy decisions and long term relations with suppliers.
Chemical Composition and Properties of Guar Polysaccharides<sup>1,2</sup> (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical Composition and Properties of Guar Polysaccharides1,2Eileen Heyne and Roy L. WhistlerCite this: J. Am. Chem. Soc. 1948, 70, 6, 2249–2252Publication Date (Print):June 1, 1948Publication History Published online1 May 2002Published inissue 1 June 1948https://pubs.acs.org/doi/10.1021/ja01186a075https://doi.org/10.1021/ja01186a075research-articleACS PublicationsRequest reuse permissionsArticle Views213Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A novel 2D-3D registration algorithm for aligning fluoro images with 3D pre-op CT/MR images (2006)

We propose a novel and fast way to perform 2D-3D registration between available intra-operative 2D images with pre-operative 3D images in order to provide better image-guidance. The current work is a feature based registration algorithm that allows the similarity to be evaluated in a very efficient and faster manner than that of intensity based approaches. The current approach is focused on solving the problem for neuro-interventional applications and therefore we use blood vessels, and specifically their centerlines as the features for registration. The blood vessels are segmented from the 3D datasets and their centerline is extracted using a sequential topological thinning algorithm. Segmentation of the 3D datasets is straightforward because of the injection of contrast agents. For the 2D image, segmentation of the blood vessel is performed by subtracting the image with no contrast (native) from the one with a contrast injection (fill). Following this we compute a modified version of the 2D distance transform. The modified distance transform is computed such that distance is zero on the centerline and increases as we move away from the centerline. This allows us a smooth metric that is minimal at the centerline and large as we move away from the vessel. This is a one time computation, and need not be reevaluated during the iterations. Also we simply sum over all the points rather than evaluating distances over all point pairs as would be done for similar Iterative Closest Point (ICP) based approaches. We estimate the three rotational and three translational parameters by minimizing this cost over all points in the 3D centerline. The speed improvement allows us to perform the registration in under a second on current workstations and therefore provides interactive registration for the interventionalist.
Eotaxin-3 but Not Eotaxin Gene Expression Is Upregulated in Asthmatics 24 Hours after Allergen Challenge (2001)

Eotaxin is an important mediator of eosinophil recruitment and activation in the airways of asthmatics. Eotaxin-2 and eotaxin-3 are two recently identified chemokines with activity similar to that of eotaxin. Using quantitative polymerase chain reaction analysis, we determined the messenger RNA (mRNA) expression of eotaxin, eotaxin-2, and eotaxin-3 relative to GAPDH mRNA expression in bronchial biopsies and bronchoalveolar lavage fluid (BALF) cells obtained from subjects with mild asthma, asthmatic subjects 24 h after allergen challenge, and normal control subjects. In bronchial biopsies, gene expression was upregulated in asthmatic subjects as compared with control subjects for eotaxin (log median values 3.18 pg/microg, 95% confidence interval [CI]; 2.27 to 3.79 versus 4.37 pg/microg, 95% CI; 3.97 to 4.65, P = 0.003) and for eotaxin-2 (0.82 pg/microg, 95% CI; 0.08 to 1.72 versus 2.97 pg/microg, 95% CI; 1.97 to 3.45, P = 0.006), but no further increase was observed after allergen challenge. In contrast, eotaxin-3 mRNA expression was not increased in asthmatic compared with control subjects, but was dramatically enhanced 24 h after challenge (median log value 1.93 pg/microg, 95% CI; 0.74 to 3.92 versus 4.62 pg/microg, 95% CI; 3.05 to 6.23, P = 0.036). No significant difference between groups was observed in BALF cell gene expression for any of the chemokines examined. These data suggest that eotaxin-3 rather than eotaxin or eotaxin-2 may account for the ongoing eosinophil recruitment to asthmatic airways in the later stages (24 h) following allergen challenge.
Advertising Frequency Decisions in a Discrete Markov Process under a Budget Constraint (1998)

The author studies the optimality of advertising pulsing under the assumption that demand follows a discrete and interpretable Markov process and that the advertising budget is constrained. The author develops two main results. First, when pulsing is optimal, the prevalence of advertising effects on switching or repurchasing affects the length of the pulse (shorter versus longer, respectively), as well as the optimal level of advertising. Second, the author identifies the functional forms of the short- and long-term effects of advertising in the discrete Markov process and shows that pulsing can be optimal if the transition probabilities are concave in advertising. As an alternative to a pure Markov carryover (if any), the author considers that carryover effects of advertising also might be caused by accumulation of memory for the advertisement. Although general results are difficult to obtain, the author analyzes one case of the compound dynamics of the Markov process and memory effects for advertising with results similar to the pure Markov process. Similarities and differences with continuous-time models, as well as managerial implications, are discussed.
Newly isolated Serotypes of infectious bronchitis virus: Their role in disease (1986)

The pathogenicity of isolates of infectious bronchitis virus (IBV) made from broiler or breeder flocks in Britain between 1981 and 1983, together with three made from flocks of commercial laying hens during 1984, has been investigated. When 11-day-old IBV-free chicks were challenged with these IBV isolates, together with a pool of pathogenic strains of E. coli, some mortality was recorded, together with a high incidence of morbidity. Three IBV isolates, when given to groups of IBV-free brown-egg laying hens, caused only a minimal effect on egg production but markedly affected egg shell colour.
Augmenting Low-cost GPS/INS with Ultra- Wideband Transceivers for Multi-platform Relative Navigation (2009)

This paper explores the use of impulse radio based Ultrawideband transceivers, an active sensor to augment the low-cost GPS/INS navigation estimates in GPSchallenged/denied environments for multi-platform relative navigation. The sensor fusion algorithm developed employs a centralized Extended Kalman filter which utilizes GPS position and velocity estimates, barometric altimeter and UWB range measurements to aid the inertial sensors. Experiment results show robust performance of the algorithm under GPS denied environments with horizontal position accuracy of 0.5m. A tactical grade IMU was used as a reference.
Neutral Ground: Switzerland and Some British Poets of the Great War (2016)

Over the years, Switzerland has been a safe-haven for artists seeking refuge from war. Situated at the center of Europe, possessing great wealth and natural beauty, and surrounded as she is by potential enemies , Switzerland has long been unique in maintaining her neutrality, especially through the two world wars of the Twentieth Century. Other neutral countries have not been so successful enforcing their neutrality. Recall the fate of Belgium and Luxembourg in both world wars: the invasion and violation of these neutrals was a central part of German strategy. But in the two world wars of the Twentieth Century, Switzerland was spared. Even in the First World War (1914-1918) when the Allies, Britain and France to the west, and Germany to the east, raced to outflank each other on the Western Front. The English Channel provided the barrier on the northwest, and on the southeast, there was the Swiss border. So what stopped them there? Perhaps it's as Stephen O'Shea has said " ... both parties to the pointless savagery realized that stalemate had descended on the mountains and that war would be won or lost elsewhere.
Reversible Privacy Preservation using Multi-level Encryption and Compressive Sensing (2019)

Security monitoring via ubiquitous cameras and their more extended in intelligent buildings stand to gain from advances in signal processing and machine learning. While these innovative and ground-breaking applications can be considered as a boon, at the same time they raise significant privacy concerns. In fact, recent GDPR (General Data Protection Regulation) legislation has highlighted and become an incentive for privacy-preserving solutions. Typical privacy-preserving video monitoring schemes address these concerns by either anonymizing the sensitive data. However, these approaches suffer from some limitations, since they are usually non-reversible, do not provide multiple levels of decryption and computationally costly. In this paper, we provide a novel privacy-preserving method, which is reversible, supports de-identification at multiple privacy levels, and can efficiently perform data acquisition, encryption and data hiding by combining multi-level encryption with compressive sensing. The effectiveness of the proposed approach in protecting the identity of the users has been validated using the goodness of reconstruction quality and strong anonymization of the faces.
Stereocontrolled Syntheses of Deoxyribonucleosides via Photoinduced Electron-Transfer Deoxygenation of Benzoyl-Protected Ribo- and Arabinonucleosides (2000)

The stereocontrolled, de novo syntheses of beta-2'-deoxy-, alpha-2'-deoxy-, beta-3'-deoxy-, and beta-2', 3'-dideoxyribonucleosides are described. Strategically protected ribose, arabinose, and xylose glycosylation precursors were synthesized bearing C2-esters capable of directing Vorbrüggen glycosylation. The key step is the regioselective deoxygenation of the desired hydroxyl group as either the benzoyl- or 3-(trifluoromethyl)benzoyl derivative. This deoxygenation is accomplished via a photoinduced electron-transfer (PET) mechanism using carbazole derivatives as the photosensitizer. The syntheses of the desired deoxynucleoside generally proceed in three steps from a common, readily available precursor.
A review of the volatiles from the healthy human body (2014)

A compendium of all the volatile organic compounds (VOCs) emanating from the human body (the volatolome) is for the first time reported. 1840 VOCs have been assigned from breath (872), saliva (359), blood (154), milk (256), skin secretions (532) urine (279), and faeces (381) in apparently healthy individuals. Compounds were assigned CAS registry numbers and named according to a common convention where possible. The compounds have been grouped into tables according to their chemical class or functionality to permit easy comparison. Some clear differences are observed, for instance, a lack of esters in urine with a high number in faeces. Careful use of the database is needed. The numbers may not be a true reflection of the actual VOCs present from each bodily excretion. The lack of a compound could be due to the techniques used or reflect the intensity of effort e.g. there are few publications on VOCs from blood compared to a large number on VOCs in breath. The large number of volatiles reported from skin is partly due to the methodologies used, e.g. collecting excretions on glass beads and then heating to desorb VOCs. All compounds have been included as reported (unless there was a clear discrepancy between name and chemical structure), but there may be some mistaken assignations arising from the original publications, particularly for isomers. It is the authors' intention that this database will not only be a useful database of VOCs listed in the literature, but will stimulate further study of VOCs from healthy individuals. Establishing a list of volatiles emanating from healthy individuals and increased understanding of VOC metabolic pathways is an important step for differentiating between diseases using VOCs.
Are Movement Artifacts in Magnetic Resonance Imaging a Real Problem?—A Narrative Review (2017)

Movement artifacts compromise image quality and may interfere with interpretation, especially in magnetic resonance imaging (MRI) applications with low signal-to-noise ratio such as functional MRI or diffusion tensor imaging, and when imaging small lesions. High image resolution has high sensitivity to motion artifacts and often prolongs scan time that again aggravates movement artifacts. During the scan fast imaging techniques and sequences, optimal receiver coils, careful patient positioning, and instruction may minimize movement artifacts. Physiological noise sources are motion from respiration, flow and pulse coupled to cardiac cycles, from the swallowing reflex and small spontaneous head movements. Par example, in resting-state functional MRI spontaneous neuronal activity adds 1-2% of signal change, even under optimal conditions signal contributions from physiological noise remain a considerable fraction hereof. Movement tracking during imaging may allow for prospective correction or postprocessing steps separating signal and noise.
Consistent environmental modeling by use of occupancy grid maps, digital road maps, and multi-object tracking (2014)

Occupancy grid mapping, street topology estimation, and object tracking are basic modules of vehicular environmental perception systems. For the sake of expandability and adaptability, this contribution proposes a hierarchical modular environmental perception architecture (HMEP). It limits the interactivity between individual basic modules. In a combination module, the consistency between occupancy grid cells and object tracks is evaluated. This allows to distinguish between static and dynamic parts of the environment in a postprocessing step. Efficient algorithms for implementation of the combination module are provided and an evaluation based on simulation and real data is presented.