gebhart/patrepeval huggingface dataset:
Killing of human malaria parasites by macrophage secretory products (1984)

The susceptibility of the human malaria parasite, Plasmodium falciparum, to killing in vitro by macrophage secretory products was investigated. The effect of O2 radicals and tumor necrosis factor on parasite viability was assessed both morphologically and by following the uptake of [3H]hypoxanthine. H2O2 produced by the interaction of glucose and glucose oxidase was found to reduce viability; this effect was reversed by the addition of exogenous catalase. Further studies indicated that the catalase level within the erythrocyte was not altered upon parasite invasion. O2 radicals produced during the xanthine-xanthine oxidase interaction also killed P. falciparum. The addition of various O2 radical scavengers (including catalase) did not reverse this effect; therefore, it was not possible to determine which of the O2 radicals were involved in the killing process. Samples from three different sources containing tumor necrosis factor, a nonspecific soluble mediator derived from Mycobacterium bovis BCG-activated macrophages treated with endotoxin, also killed the parasite. There was no evidence that tumor necrosis factor or the products of the xanthine-xanthine oxidase interaction caused damage to the erythrocyte membrane that could be implicated as an important aspect of the killing process. These findings all strongly suggest that such macrophage products play an important role in immunity to malaria.
Voltage-controlled crystal oscillators (1971)

The quartz crystal oscillator is normally thought of as a stable generator of a fixed frequency. It is possible, however, to design and construct voltage tunable quartz crystal oscillators that can be electrically tuned over a frequency range on the order of ±0.3 percent of the crystal frequency. This is accomplished with a nonlinearity between frequency and voltage on the order of 0.1 percent. Moderately good long-term frequency stability and low phase noise is exhibited by the oscillators. A reactive network including varactor diodes is used to provide a voltage variable reactance which, in combination with a quartz crystal network, forms a resonator having an antiresonant frequency that is a linear function of tuning voltage. The basic reactance network is not practically realizable. However, the application of one of Norton's network transformation theorems results in a realizable network. The oscillator described is very simple in design and provides an inexpensive solution to a large number of signal processing and measurement problems.
Low magnetic field measurement with a reversed-field electron-spin-resonance magnetometer (2000)

An effective method of measuring low magnetic fields is presented. In this method, the magnetic field direction is reversed periodically so that the effects of external magnetic fields, such as the earth's magnetism, are removed. The usefulness of the method is investigated by using a split coil magnetic field source and an electron-spin-resonance magnetometer. A magnetic field of 10 mT can be measured with an uncertainty of less than 0.2 /spl mu/T, i.e., 20 ppm.
Improved Pharmacokinetics of Sumatriptan With <scp>B</scp> reath <scp>P</scp> owered™ Nasal Delivery of Sumatriptan Powder (2013)

Breath Powered intranasal delivery of sumatriptan powder is a more efficient form of drug delivery, producing a higher peak and earlier exposure with a lower delivered dose than nasal spray and faster absorption than either nasal spray or oral administration. It also produces a significantly lower peak and total systemic exposure than oral tablet or subcutaneous injection.
Hydrogen peroxide‐sensitive electrode based on horseradish peroxidase‐modified platinized carbon (1994)

Abstract Elearodes are described based on horseradish peroxidase (HRP) modified platinized carbon particles which are capable of reducing hydrogen peroxide at 0.0 V (vs. SCE). The HRP was covalently attached to the surface of the carbon particles via cyanuric chloride. Energy‐dispersive X‐ray analysis confirmed the presence of cyanuric chloride on the surface of the carbon. Electrochemical studies on these electrodes indicated that they were stable for extended periods and that the bound HRP was capable of mediating the electrocatalytic reduction of hydrogen peroxide.
Integrated Planning for Telepresence with Time Delays (2006)

Teleoperation of remote robotic systems over time delays in the range of 2-10 seconds poses a unique set of challenges. In the context of a supervisory control system for the JSC Robonaut humanoid robot, we have developed an "intelligent assistant" that integrates an artificial intelligence planner (JSH0P2) with execution monitoring of the state of both the human supervisor and the remote robot. The assistant reasons simultaneously about the world state on both sides of the time delay, which represents a novel application of this technology. The purpose of the assistant is to provide advice to the human supervisor about current and future activities, derived from a sequence of high-level goals to be achieved. To do this, the assistant must simultaneously monitor and react to various data sources, including actions taken by the supervisor who is issuing commands to the robot (e.g. with a data glove), actions taken by the robot, and the environment of the robot, both as currently perceived over the time delay, along with the current sequence of goals. We have developed a "leader/follower" software architecture to handle the dual time-shifted streams of execution feedback. In this paper we describe the integrated planner and its executive, and how it operates in normal and anomaly situations.
Fuzzy vector quantazation applied to hidden Markov modeling (2005)

This paper investigates the use of a fuzzy vector quantizer (FVQ) as the front end for a hidden Markov modeling (HMM) scheme for isolated word recognition. Unlike a standard vector quantizer that generates the index of a single codeword that best matches an input vector, an FVQ generates a vector whose components represent the degree to which each codeword matches the input vector. The HMM algorithm is generalized to accommodate the FVQ output. This approach is tested on a database of isolated words from a single male speaker. It is seen that the FVQ front end significantly reduces the amount of data needed to train the HMM algorithm.
Numerical Investigation of the Effect of Different Back Sweep Angle and Exducer Width on the Impeller Outlet Flow Pattern of a Centrifugal Compressor With Vaneless Diffuser (2006)

This paper presents a numerical investigation of the effect of different back sweep angles and exducer widths on the steady-state impeller outlet flow pattern of a centrifugal compressor with a vaneless diffuser. The investigations have been performed with commercial CFD and in-house programmed 1-D codes. CFD calculations aim to investigate how flow pattern from the impeller is quantitatively influenced by compressor geometry parameters; thereby, the location of wake and its magnitude (flow angle and relative velocity magnitude) are analyzed. Results show that the increased back sweep impeller provides a more uniform flow pattern in terms of velocity and flow deviation angle distribution, and offers better potential for the diffusion process inside a vaneless (or vaned) diffuser. Secondary flux fraction and flow deviation angle from CFD simulation are implemented into the 1-D two-zone program to improve 1-D prediction results.
Hardware-accelerated parallel non-photorealistic volume rendering (2002)

Non-photorealistic rendering can be used to illustrate subtle spatial relationships that might not be visible with more realistic rendering techniques. We present a parallel hardware-accelerated rendering technique, making extensive use of multi-texturing and paletted textures, for the interactive non-photorealistic visualization of scalar volume data. With this technique, we can render a 512x512x512 volume using non-photorealistic techniques that include tone-shading, silhouettes, gradient-based enhancement, and color depth cueing, as shown in the images on the color plate, at multiple frames second. The interactivity we achieve with our method allows for the exploration of a large visualization parameter space for the creation of effective illustrations.
Mechanisms and Consequences of Centrosome Clustering in Cancer Cells (2012)

Ever since initially proposed by Theodor Boveri in 1914, centrosome abnormalities have been accused to be involved in the induction of chromosomal instability and tumorigenesis. New evidence especially on a mechanism termed centrosomal clustering now again supports Boveri's idea and adds fuel to the old debate on a mechanistic link between supernumerary centrosomes and malignant transformation. On top, inhibiting centrosome clustering might well turn out to be one of the long sought after possibilities to specifically interfere with tumor cells while leaving healthy tissues untouched.
Improving Deployability of Peer-Assisted CDN Platform with Incentive (2009)

As a promising solution to manage the huge workload of large-scale VoD services, managed peer-assisted CDN systems, such as P4P has attracted attention. Although the approach works well in theory or in a controlled environment, to our best knowledge, there have been no general studies that address how actual peers can be incentivized in the wild Internet; thus, deployablity of the system with respect to incentives to users has been an open issue. With this background in mind, we propose a new business model that aims to make peer-assisted approaches more feasible. The key idea of the model is that users sell their idle resources back to ISPs. In other words, ISPs can leverage resources of cooperative users by giving them explicit incentives, e.g., virtual currency. We show the high-level framework of designing optimal incentive amount to users. We also analyze how incentives and other external factors affect the efficiency of the system through simulation. Finally, we discuss other fundamental factors that are essential for the deployability of managed peer-assisted model. We believe that the new business model and the insights obtained through this work are useful for assessing the practical design and deployment of managed peer-assisted CDNs.
The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas. (2001)

The human TAX-1 gene encodes a Mr 135,000 glycoprotein that is transiently expressed on the surface of a subset of neurons during development and is involved in neurite outgrowth. The TAX-1 gene has been mapped to a region on chromosome 1 that has been implicated in microcephaly and the Van der Woude syndrome. Using restriction landmark genome scanning to search for amplified genes in gliomas, we found TAX-1 to be amplified in 2 high-grade gliomas among a group of 26 gliomas investigated. Real-time reverse transcription-quantitative PCR analysis detected high levels of TAX-1 mRNA in glial tumors, even in the absence of TAX-1 gene amplification. Immunohistochemical analysis revealed abundant levels of TAX-1 in neoplastic glial cells of glioblastoma multiforme tumors. Because glial tumors are highly invasive and in view of the role of TAX-1 in neurite outgrowth, we investigated the potential role of TAX-1 in glioma cell migration. Using an in vitro assay, we found that the migration of glioma tumor cells is profoundly reduced in the presence of either an anti-TAX-1 antibody or a TAX-1 antisense oligonucleotide. Our findings suggest that TAX-1 plays a role in glial tumorigenesis and may provide a potential target for therapeutic intervention.
Stress relaxation during thermal cycling in metal/polyimide layered films (1988)

The stress relaxation behavior during thermal cycling of metal/quartz and metal/polyimide/quartz layered structures has been investigated using a cantilever bending beam technique. The metals chosen for this study include Cu and Cr, two materials with contrasting mechanical and interfacial bonding properties. A finite element analysis, as well as an analytical calculation, has been carried out to deduce the stress distribution in the layered structures. Results indicate that the extent of stress relaxation strongly depends on the intrinsic mechanical property of the metal film with significantly higher stresses residing in the Cr film than in the Cu film. The interfacial polyimide layer has been found to serve as an effective buffering layer to reduce the residual stress in metal films. Observations from transmission electron microscopy suggest that the stress is partially released through the deformation of the polyimide near the metal/polyimide interface.
GasP: a minimal FIFO control (2002)

The GasP family of asynchronous circuits provides controls for simple pipelines, for branching and joining pipelines, for round-robin scatter and gather for data dependent scatter and gather and for join on demand through arbitration. The family is designed so that each stage operates at the speed of a three-inverter ring oscillator Test chips in 0.35 micron technology exhibit throughput in excess of 1.5 giga data items per second (GDI/s). Between GasP pipeline stages a single wire carries both request and acknowledge messages, also recording the FULL or EMPTY state of each pipeline stage. GasP control circuits rely on careful choice of transistor widths to equalize the delay in logic gates. Assurance of uniform gate delays permits use of self-resetting logic forms that have very low logical effort.
Immunogenic potential of irradiated lymphoma cells is enhanced by adjuvant immunotherapy and modulation of local macrophage populations (2013)

The aim of this study was to assess the immunogenic potential of irradiated lymphoma cells in vivo and determine whether immunogenicity can be enhanced by modulation of the host immune system. Syngeneic murine lymphoma models irradiated ex vivo were used as an orthotopic cellular vaccination prior to challenge with viable tumor cells. We demonstrate that irradiated lymphoma cells are poorly immunogenic and that protective anti-tumor CD8 T-cell responses require the addition of immunostimulatory monoclonal antibody as an immune adjuvant, and increased frequency of antigen exposure by multiple vaccinations. Furthermore, we show the potential importance of macrophages in regulating immunogenicity of irradiated lymphoma cells and demonstrate that depletion of macrophages using clodronate-encapsulated liposomes considerably enhances primary vaccination efficacy in the presence of adjuvant anti-CD40 antibody. Our results demonstrate that the immunogenic potential of poorly immunogenic lymphoma cells dying after radiation therapy can be improved by modulation of the host immune system.
DCIM: Distributed Cache Invalidation Method for Maintaining Cache Consistency in Wireless Mobile Networks (2012)

This paper proposes distributed cache invalidation mechanism (DCIM), a client-based cache consistency scheme that is implemented on top of a previously proposed architecture for caching data items in mobile ad hoc networks (MANETs), namely COACS, where special nodes cache the queries and the addresses of the nodes that store the responses to these queries. We have also previously proposed a server-based consistency scheme, named SSUM, whereas in this paper, we introduce DCIM that is totally client-based. DCIM is a pull-based algorithm that implements adaptive time to live (TTL), piggybacking, and prefetching, and provides near strong consistency capabilities. Cached data items are assigned adaptive TTL values that correspond to their update rates at the data source, where items with expired TTL values are grouped in validation requests to the data source to refresh them, whereas unexpired ones but with high request rates are prefetched from the server. In this paper, DCIM is analyzed to assess the delay and bandwidth gains (or costs) when compared to polling every time and push-based schemes. DCIM was also implemented using ns2, and compared against client-based and server-based schemes to assess its performance experimentally. The consistency ratio, delay, and overhead traffic are reported versus several variables, where DCIM showed to be superior when compared to the other systems.
Quantitative Analysis of Oxidized Guanine, 8-Oxoguanine, in Mitochondrial DNA by Immunofluorescence Method (2009)

8-Oxoguanine (8-oxoG), an oxidized form of guanine, is one of the major mutagenic lesions generated under oxidative stress. Oxidative damage in mitochondrial DNA has been implicated as a causative factor for a wide variety of degenerative diseases as well as for cancer during aging. We established a quantitative method for in situ detection of 8-oxoG in mitochondrial DNA in a single-cell level using a monoclonal antibody. Specific detection of 8-oxoG in mitochondrial DNA was confirmed by pre-treatment of samples with DNase I or MutM, the latter excising 8-oxoG opposite C in DNA. We then analyzed 8-oxoG dynamics in mitochondrial DNA of the wild-type and 8-oxoG DNA glycosylase (OGG1)-deficient mouse cells after exposure to hydrogen peroxide. Intensities for the 8-oxoG immunoreactivity in mitochondrial DNA were increased immediately after the exposure to hydrogen peroxide in both types of cells. The increased intensities returned to basal levels within a few hours only in wild-type cells, but not in OGG1-deficient cells which exhibited the increased intensities even 24 h after the exposure. These results indicate that OGG1 is a major enzyme for excision repair of 8-oxoG in mitochondrial DNA in mouse cells, and that our method described here is appropriate to study 8-oxoG dynamics in mitochondrial DNA.
TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism (2009)

The pathogenesis of LPS-induced acute kidney injury (AKI) requires signaling through tumor necrosis factor-alpha (TNF) receptor 1 (TNFR1), which within the kidney is primarily located in the endothelium. We showed previously that caspase inhibition protected mice against LPS-induced AKI and in parallel significantly inhibited LPS-induced renal inflammation. Therefore we hypothesized that caspase activation amplifies TNF-induced inflammation in renal endothelial cells (ECs). In cultured renal ECs, TNF induced apoptosis through a caspase-8-dependent pathway. TNF caused translocation of the p65 subunit of NF-kappaB to the nucleus, resulting in upregulation of inflammatory markers such as adhesion molecules ICAM-1 and VCAM-1. However, the broad-spectrum caspase inhibitor Boc-d-fmk reduced NF-kB activation as assessed by gel shift assay, reduced phosphorylation of subunit IkappaBalpha, and significantly inhibited TNF-induced expression of ICAM-1 and VCAM-1 as assessed by both real-time PCR and flow cytometry. Broad-spectrum caspase inhibition markedly inhibited neutrophil adherence to the TNF-activated endothelial monolayer, supporting the functional significance of this effect. Specific inhibitors of caspases-8 and -3, but not of caspase-1, reduced TNF-induced NF-kappaB activation. Caspase inhibition also reduced TNF-induced myosin light chain (MLC)-2 phosphorylation, and activation of upstream regulator RhoA. Consistent with this, MLC kinase (MLCK) inhibitor ML-7 reduced TNF-induced NF-kappaB activation. Thus caspase activation influences NF-kappaB signaling via its affect on cytoskeletal changes occurring through RhoA and MLCK pathways. These cell culture experiments support a role for caspase activation in TNF-induced inflammation in the renal endothelium, a key event in LPS-induced AKI.
Operation of a 1-kHz pulse-pumped Ti:sapphire regenerative amplifier (1990)

We demonstrate the operation of a Ti:sapphire laser pumped at a 1-kHz repetition rate by a frequency-doubled Nd:YLF laser. We have operated this laser to amplify regeneratively 22-psec pulses from a synchronously pumped dye laser, producing up to 300 mJ of energy in a 22-psec pulse at 1 kHz.
Data recovery for web applications (2010)

Web-based applications store their data at the server side. This design has several benefits, but it can also cause a serious problem because a misconfiguration, bug or vulnerability leading to data loss or corruption can affect many users. While data backup solutions can help resolve some of these issues, they do not help diagnose the events that led to the corruption or the precise set of changes caused by these events. In this paper, we describe the design of a recovery system that helps administrators recover from data corruption caused by bugs in web applications. Our system tracks application requests, helping identify requests that cause data corruption, and reuses undo logs already kept by databases to selectively recover from the effects of these requests. The main challenge is to correlate requests across the multiple tiers of the application to determine the correct recovery actions. We explore using dependencies both within and across requests at three layers (database, application, and client) to help identify data corruption accurately. We evaluate our system using known bugs in popular web applications, including Wordpress, Drupal and Gallery2. Our results show that our system enables recovery from data corruption without loss of critical data and incurs small runtime overhead.
Facile thermal dimerization of a photochemically isomerized olefin. (1976)

In sharp contrast to 4-methyl-2-methoxycarbonylmethylene-3, 4-dihydro-3-oxo-2H-1, 4-benzothiazine (Z-form), the photochemically produced isomer (E-form) underwent a facile thermal dimerization to form a cyclobutane derivative. The present observation is notable for demonstrating that the apparent photodimerization of the open-chain olefin could involve primarily the thermal dimerization of its isomer formed photochemically.
National Aglaw Center Research Article, J.E.M. Ag Supply, Inc. V. Pioneer Hi-bred International, Inc.: its Meaning and Significance for the Agricultural Community (2003)

Biotechnology development in agriculture has raised challenging intellectual property issues. These issues are framed in the context of a three-prong plant patent statutory scheme, involving the Utility Patent Act, the Plant Variety Protection Act, and the Plant Patent Act. The agricultural community, which includes agricultural biotechnology companies, seed companies, and agricultural producers, has debated whether utility patents are excluded from the scope of the Utility Patent Act. Producers contended that Congress superceded the Utility Patent Act when it created the Plant Variety Protection Act and the Plant Patent Act and that sexually reproducing plants (seeds and seed grown plants) are protected exclusively by federal law under the provisions of the Plant Variety Protection Act. Seed companies, on the other hand, retorted that sexually reproducing plants are within the scope of the Utility Patent Act and that neither the Plant Protection Act nor the Plant Variety Protection Act superceded the Utility Patent Act. The dispute was resolved in December 2001, by the United States Supreme Court in J.E.M. Ag Supply, Inc. v. Pioneer Hi-Bred International, holding that utility patents may be issued for plants under the Utility Patent Act, despite distinct protections available under the Plant Variety Protection Act and the Plant Protection Act. This article outlines the factual, procedural, and legal background of the dispute in J.E.M. and explains the rationale and scope of the Supreme Court’s decision. This article also addresses the meaning and significance of the decision to the agricultural community. Articles Editors, Matt Morris & Joe Rupcich.
An embedded declarative data transformation language (2009)

We introduce a logic programming framework for data type transformations based on isomorphisms between elementary data types (natural numbers, finite functions, sets and permutations, digraphs, DAGs, hypergraphs, etc.) and automatically derived extensions to hereditarily finite universes through ranking/unranking operations.