gebhart/patrepeval huggingface dataset:
Mechanism of the glucocorticoid regulation of growth of the androgen-sensitive prostate-derived R3327H-G8-A1 tumor cell line. (1985)

The R3327H-G8-A1 cell line derived from the Dunning rat prostate adenocarcinoma contains both androgen and glucocorticoid receptors. Following steroid deprivation, androgens specifically increase the concentration of their receptors in these cells by approximately 2-fold within 6 h and 3-4-fold in 24 h. In the presence of potent glucocorticoids, androgen receptor augmentation is reduced by 40-50% in the first 6 h and completely inhibited during the subsequent 24 h. This event, which is specific for glucocorticoids, appears to be due to an inhibition of androgen receptor synthesis. Furthermore, glucocorticoids inhibit proliferation of these cells by inhibiting the release of growth factors and arresting them in the G0 or A state of the cell cycle. This inhibition can be overcome by addition of low concentrations of either epidermal growth factor or platelet-derived growth factor; however, the inhibitory effect of the glucocorticoid on androgen receptor augmentation is not released. These results suggest that glucocorticoids arrest cellular proliferation by altering the autoregulation of growth and that this event is not dependent upon inhibition of androgen receptor augmentation.
CMAC: an associative neural network alternative to backpropagation (1990)

The CMAC (cerebellar model arithmetic computer) neural network, an alternative to backpropagated multilayer networks, is described. The following advantages of CMAC are discussed: local generalization, rapid algorithmic computation based on LMS (least-mean-square) training, incremental training, functional representation, output superposition, and a fast practical hardware realization. A geometrical explanation of how CMAC works is provided, and applications in robot control, pattern recognition, and signal processing are briefly described. Possible disadvantages of CMAC are that it does not have global generalization and that it can have noise due to hash coding. Care must be exercised (as with all neural networks) to assure that a low error solution will be learned.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Power measurement as the basis for power management (2005)

Energy has become a critical component of computer system design, particularly in the embedded space where the source of energy is often finite. While hardware design has the more significant effect on the system&apos;s power consumption, well designed system and application software make an important contribution to controlling the energy consumed. In order to
Processing and Dielectric Properties of La(Mg<sub>0.5</sub>Ti<sub>0.5</sub>)O<sub>3</sub>–BaTiO<sub>3</sub>Ceramics (2003)

Abstract (1−x)La(Mg0.5Ti0.5)O3-xBaTiO3 (0 ≤ x ≤ 0.7) perovskite ceramics have been prepared by a chemical method and their permittivity and dielectric loss have been studied over a wide frequency range. The far infrared complex dielectric function has been evaluated from reflectivity data and extrapolated towards the microwave range. For the compositions with x = 0 and 0.1, both the measured at microwave range and extrapolated values were found to be in good agreement, revealing that microwave losses are essentially intrinsic and due to lattice contributions. For solid solutions with higher BaTiO3 content, the results suggest that additional contributions are present. The analysis of the temperature dependence of the low frequency permittivity indicates that a possible additional mechanism may be ionic conduction. The comparison of the dielectric behaviour observed in ceramics sintered in oxygen and air suggests that the oxygen vacancies due to the reducing of Ti4+ seems to play an important role in the onset of the ionic conduction. Keywords: Ceramics microwave properties infrared spectroscopy ionic conduction
Concomitant ethynylation and esterification reaction (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConcomitant ethynylation and esterification reactionElliot L. Shapiro, Lawrence Finckenor, and Hershel L. HerzogCite this: J. Org. Chem. 1968, 33, 4, 1673–1675Publication Date (Print):April 1, 1968Publication History Published online1 May 2002Published inissue 1 April 1968https://pubs.acs.org/doi/10.1021/jo01268a090https://doi.org/10.1021/jo01268a090research-articleACS PublicationsRequest reuse permissionsArticle Views117Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Lanthanide macrocyclic complexes, 'quantum dyes': optical properties and significance</title> (1993)

Macrocylic complexes of the lanthanide (III) ions were functionalized to permit their attachment to antibodies, nucleic acid probes, and any other species capable of specific binding. The Eu(III) complex was found to possess a combination of properties (water solubility, inertness to metal release, ligand-sensitized luminescence, reactive peripheral functionalities) that make it suitable as a luminescent marker for bio-substrates. Its coupling to avidin was achieved, and the properties of the resulting conjugate were investigated.
Vigorous Innate and Virus-Specific Cytotoxic T-Lymphocyte Responses to Murine Cytomegalovirus in the Submaxillary Salivary Gland (2003)

To better understand the immunological mechanisms that permit prolonged shedding of murine cytomegalovirus (MCMV) from the salivary gland, the phenotypic and functional characteristics of leukocytes infiltrating the submaxillary gland (SMG) were analyzed in infected BALB/c mice. A robust innate immune response, comprised of CD11c+ major histocompatibility complex class II+ CD11b- CD8alpha+ dendritic cells and gamma/delta T-cell receptor-bearing CD3+ T cells was prominent through at least 28 days postinfection. Concurrently, a dramatic increase in pan-NK (DX5+) CD3+ and CD8+ T cells was observed, while CD4+ T cells, known to be essential for viral clearance from this tissue, increased slightly. The expression particularly of gamma interferon but also of interleukin-10 and CC chemokines was extraordinarily high in the SMG in response to MCMV infection. The gamma interferon was produced primarily by CD4+ and CD8+ T lymphocytes and DX5+ CD3+ T cells. The SMG CD8+ T cells were highly cytolytic ex vivo, and a significant proportion of these cells were specific to an immunodominant MCMV peptide. These peptide-specific clones were not exhausted by the presence of high virus titers, which persisted in the SMG despite the strength of the cell-mediated responses. In contrast, MCMV replication was efficiently cleared from the draining cervical and periglandular lymph nodes, a tissue displaying a substantially weaker antiviral response. Our data indicated that vigorous innate and acquired immune responses are elicited, activated, and retained in response to mucosal inflammation from persistent MCMV infection of the submaxillary gland.
Implementation of Pitch Detection Based on ACF by Matlab (2010)

Many further studies have been done on the basis of analyzing the autocorrelation algorithm in this paper.A band-pass filter and a tri-level clipping module was adopted to improve the detection which took the accuracy and the detection rate into account.Based on Matlab and processing a specific voice,the estimation method was designed,more accurate voice pitch period of the voice sound has been obtained.The experiments showed that the method was simple and efective.
Projections for insulin treatment for diabetics (2002)

The evolution of insulin treatment of diabetes has dramatically changed the natural course of this disease. Modern recombinant DNA technology has brought about many new insulin analogues with improved pharmacokinetics, resulting in better glycemic control. In addition, improved insulin delivery systems, such as insulin pumps and pens, have been introduced to provide convenience and to enhance patient compliance. Efforts are currently being devoted to developing noninvasive insulin formulations, such as oral and pulmonary insulin. A number of products are at different stages of clinical trials. Meanwhile, the quest for a permanent cure for diabetes continues. The frontier of diabetes research has gone through a period of substantial expansion, with the emergence of new areas that include gene therapy, islet cell transplantation and diabetic vaccine. Technological breakthroughs, such as recombinant DNA, nanotechnology, microarray-aided genomics and proteomics, will provide more profound insights into the pathogenesis, and the immunological and biological basis of diabetes. Our growing knowledge in these areas will ultimately contribute to the discovery of preventive methods against or a cure for this disease.
Kinematics of hyper-redundant robot locomotion with applications to grasping (2002)

Simple schemes for analyzing the kinematics of hyper-redundant robot locomotion over solid terrain are considered. These schemes are based on the concepts of amplitude varying and traveling wave gaits, which are idealized models of inchworm and caterpillar locomotion. The kinematics of these gaits is formulated for hyper-redundant robots of both constant and variable length for locomotion over both flat and irregular terrain. Hyper-redundant locomotion concepts are applied to a novel grasping and fine manipulation scheme based on a grasping wave.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A 60-GHz Power Amplifier Design Using Dual-Radial Symmetric Architecture in 90-nm Low-Power CMOS (2013)

An innovative on-chip 3-D power amplifier (PA) architecture for <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</i> -way power-combined CMOS PAs by using the proposed dual-radial symmetric architecture is presented. It provides design freedom of impedance selection of power device in transformer-based millimeter-wave PA design. This idea also makes distinguished breakthrough to the traditional 2-D PA architecture without compromising symmetry and compact size of layout. To demonstrate the feasibility of this idea, a 60-GHz PA is fabricated in 90-nm low-power CMOS process. It is also equipped with multi-mode operation. It achieves an output power of 18.5 dBm and a power-added efficiency of 10.2% with 1.2-V supply voltage. At 6-dB/10-dB power back-off operation, the drain efficiencies of power stage can be enhanced from 5.9%/2.4% to 11.9%/8%, respectively, by enabling the multi-mode operation.
Pseudomonas aeruginosa (2004)

Pseudomonas aeruginosa produces multiple virulence factors and causes different types of infections. Previous clinical studies identified P. aeruginosa isolates that lack individual virulence factors. However, the impact of losing several virulence factors simultaneously on the in vivo virulence of P. aeruginosa is not completely understood. The P. aeruginosa cell-to-cell communication system, or quorum sensing (QS), controls the production of several virulence factors.AnimalstudiesusingconstructedQSmutantsindicatedthatlossoftheQSsystemseverely impactsthevirulenceofP.aeruginosa.Inthisstudy,wetriedtodetermineifdeficiencywithintheQS system compromises the ability of P. aeruginosa to establish infections in humans. We have identified five QS-deficient strains through screening 200 isolates from patients with urinary tract, lower respiratory tract and wound infections. These strains lacked LasB and LasA activities and produced either no or very low levels of the autoinducers N-(3-oxododecanoyl) homoserine lactone and N-butyryl homoserine lactone. PCR analysis revealed that three isolates contained all four QS genes (lasI, lasR, rhlI and rhlR) while two isolates lacked both the lasR and rhlR genes. We also examined the five isolates for other virulence factors. The isolates produced variable levels of exotoxin A and, with one exception, were deficient in pyocyanin production. One isolate produced the type III secretion system (TTSS) effector proteins ExoS and ExoT, two isolates produced ExoT onlyandtwoisolatesproducednoTTSSproteins.Theisolatesproducedweaktomoderatebiofilms on abiotic surfaces. Analysis of the patients’ data revealed that two of the isolates represented a single strain that was isolated twice from the same patient within a 1 month interval. One QS
국내 체육,스포츠 진흥법에 관한 연구 (2015)

The study conducted an investigation on Physical Education(p.E) & Sports promotion acts in order to find facts about them and provide basic data necessary for the establishment and operation of policy for Physical Education & Sports. The investigation showed that promotion acts account for 53 cases(4.55%) of total statutes of Korea and P.E & Sports promotion acts account for 4 cases of total promotion acts. Those are National physical education promotion law, Sports industry promotion law, Tradition military arts promotion law, Law about Taekwondo promotion and Taekwondo park furtherance elc, proving that P.E & Sports promotion acts stiU holds an insignificant standing in the whole statutes of Korea. Oassified sports law most had regulation legal special quality but Physical Education & Sports promotion law have grandeur legal special quality was account for 16% of total P.E & Sports law. P.E & Sports promotion law of 3 cases(Sports industry promotion law, Tradition military arts promotion law, Law about Taekwondo promotion and Taekwondo park furtherance etc) except National physical education promotion law in 17th congress as established law.
Assessing the Antioxidant Activity of Melanoidins from Coffee Brews by Different Antioxidant Methods (2005)

Antioxidant activity of instant coffees produced from the same green coffee beans roasted at three different degrees was analyzed. Coffee melanoidins were obtained by ultrafiltration (10 kDa cutoff) and subsequent diafiltration. Pure melanoidins were isolated from melanoidins after overnight incubation in 2 M NaCl and then ultrafiltered. Filtrates, corresponding to the low molecular weight (LMW) fraction noncovalently linked to the melanoidin skeleton, were also preserved. Antioxidant activity of coffee brews (CB), melanoidins (M), pure melanoidins (PM), and bounded melanoidin compounds (BMC) were tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and ferric reducing power (FRAP) methods. The correlation between the different methods was studied. The higher contribution of melanoidins to the total antioxidant activity of coffees was shown to be caused by the LMW compounds linked noncovalently to the melanoidin skeleton, as data from BMC confirmed. CB, M, and BMC fractions exert the highest antioxidant activity in aqueous media, whereas PM was not dependent on the reaction media. The highest correlation was found between DPPH and FRAP methods.
Etching of Silicon in HBr Plasmas for High Aspect Ratio Features (2002)

Etching in semiconductor processing typically involves using halides because of the relatively fast rates. Bromine containing plasmas can generate high aspect ratio trenches, desirable for DRAM and MEMS applications, with relatively straight sidewalk We present scanning electron microscope images for silicon-etched trenches in a HBr plasma. Using a feature profile simulation, we show that the removal yield parameter, or number of neutrals removed per incident ion due to all processes (sputtering, spontaneous desorption, etc.), dictates the profile shape. We find that the profile becomes pinched off when the removal yield is a constant, with a maximum aspect ratio (AR) of about 5 to 1 (depth to height). When the removal yield decreases with increasing ion angle, the etch rate increases at the comers and the trench bottom broadens. The profiles have ARs of over 9:1 for yields that vary with ion angle. To match the experimentally observed etched time of 250 s for an AR of 9:1 with a trench width of 0.135 microns, we find that the neutral flux must be 3.336 x 10(exp 17)sq cm/s.
One-Shot Visual Imitation Learning via Meta-Learning (2017)

In order for a robot to be a generalist that can perform a wide range of jobs, it must be able to acquire a wide variety of skills quickly and efficiently in complex unstructured environments. High-capacity models such as deep neural networks can enable a robot to represent complex skills, but learning each skill from scratch then becomes infeasible. In this work, we present a meta-imitation learning method that enables a robot to learn how to learn more efficiently, allowing it to acquire new skills from just a single demonstration. Unlike prior methods for one-shot imitation, our method can scale to raw pixel inputs and requires data from significantly fewer prior tasks for effective learning of new skills. Our experiments on both simulated and real robot platforms demonstrate the ability to learn new tasks, end-to-end, from a single visual demonstration.
A New Staurosporine Analog from the Prosobranch Mollusk<i>Coriocella Nigra</i> (1999)

Abstract A new staurosporine analog, 4′-N-demethyl-11-hydroxystaurosporine (1), has been isolated by cytotoxicity-guided fractionation of an organic extract of the prosobranch mollusk Coriocella nigra. The known staurosporine derivative 3,11-dihydroxystaurosporine (2) was also isolated from this extract. Concurrent investigations of Coriocella hibyae resulted in the isolation of two known compounds, lamellarins C (3) and U (4). The structures of 1, 2, 3 and 4 were elucidated by spectroscopic methods and the compounds were evaluated for cytotoxicity against 10 human tumor cell lines. Compounds 1 and 2 demonstrated potent cytotoxic activity with IC50's ranging from approximately 2 to 66 ng/mL. Key Words: Coriocella nigraCoriocella hibyaestaurosporineprosobranch mollusk
Thermal Residual Stress Relaxation and Distortion in Surface Enhanced Gas Turbine Engine Components (1998)

Compressive residual stresses are often de{deliberately induced in the surfaces of turbine engine components using a variety of surface enhancement methods to improve fatigue life. Thermal stress relaxation can occur in both the Ti and Ni alloys used in compressor and turbine stages Nonuniform relaxation of the compressive layer can cause distortion of the critical aerodynamics shapes of thin blades potentially effecting engine performance.
Boric Acid (2001)

[10043-35-3] BH3O3 (MW 61.83) InChI = 1S/BH3O3/c2-1(3)4/h2-4H InChIKey = KGBXLFKZBHKPEV-UHFFFAOYSA-N (reacts with alcohols to form borate esters;1 catalyzes dehydration,2 hydrolysis,3 decarboxylation,4 and condensation reactions;5 useful in carbohydrate chemistry6) Physical Data: mp 169 °C; d 1.435 g cm−3. Heating boric acid above 100 °C gradually produces metaboric acid, HBO2; at higher temperatures all water is lost and boron oxide, B2O3, results. Solubility: sol cold water (1 g in 18 mL), boiling water (1 g in 4 mL), cold alcohol (1 g in 18 mL), boiling alcohol (1 g in 6 mL), glycerol (1 g in 6 mL), acetone (1 g in 15 mL). Form Supplied in: white solid, widely available (see also Sodium Tetraborate). Purification: recrystallize three times from water (3 mL g−1) with filtering. Dry over metaboric acid in a desiccator. Handling, Storage, and Precautions: boric acid is hygroscopic. It is an irritant to eyes, skin, and mucous membranes, and should be handled with the appropriate precautions to eliminate contact with these areas. Death has resulted from ingestion of 5 to 20 g in adults. Use in a fume hood.
CSF tau/Aβ <sub>42</sub> ratio for increased risk of mild cognitive impairment (2007)

These generally applicable methods establish cutoff values to identify control individuals at increased risk of conversion to mild cognitive impairment which may be useful to people weighing the risk-benefit ratio of new preventive therapeutics and to researchers striving to enrich clinical trial populations with people with latent Alzheimer disease.
TravTek evaluation overview and recruitment statistics (1993)

TravTek is the operational field test of an advanced driver information and traffic management system. The evaluation of TravTek is being performed through the execution of twelve integrated studies within six study areas. Most of the evaluation data were obtained during the operation of 100 specially instrumented TravTek cars in Orlando, Florida. The TravTek system is briefly described, and the status of the evaluation studies is reviewed. Seven of the studies, where volunteer drivers were employed, are covered in greater detail with associated recruitment statistics and survey response rates.
Hypertext to hypermedia and beyond (1997)

The phenomenal growth of new forms of hypermedia, especially for the World Wide Web, has been fueled by the ability for authors to easily and cheaply publish electronic documents to a worldwide audience. As these electronic "hype? documents have become larger and more complex, however, hardware and software vendors have experienced the limitations of their products with the new media To address the requirements of evermore demanding users and to enable the further expansion of electronic publishing technology into new domains of distribution, primarily the World Wide Web, three technoIogies are among those currently leading the way to the future -Hypertext Markup Language (IlTML) 4.0; and for applications that require functionality beyond HI'ML, the Extensible Markup Language (XML) and the Virtual Reality Modeling Language (VRML). This paper &scribes these efforts and discusses new kinds of Web applications made possible by these technologies. 1
BP-294 Ste Civile Bioprojet. (2000)

BP-294 (a prodrug of R-alpha-methylhistamine) is a histamine H3 agonist under development by Bioprojet and in phase II clinical trials as an antiasthmatic [219798]. In a study, R-alpha-methylhistamine was shown to inhibit the release of acetylcholine, in the presence of atropine (1 microM) and 0.5 Hz of electrical stimulation of the rat bilateral vagus nerve, in a dose-dependent manner. This inhibition was abolished by thioperamide [321838].
Comparing Stroke Incidence Worldwide (1996)

The "ideal" stroke incidence study does not exist, but studies closely approaching it will reveal the most reliable and comparable results. There is a need for further studies to fill the gaps in our knowledge of the worldwide incidence of stroke, particularly for developing countries.