gebhart/patrepeval huggingface dataset:
Strengthening Communities with Neighborhood Data (2015)

In the two decades since the first NNIP data system was developed, dramatic changes have occurred in the community information field and its context. First, the partnership itself has expanded, with local partners now in about three dozen cities. The local partners and the partnership have completed a substantial body of work, including policy and community-building applications, technical innovations, and guidebooks for practitioners.
Comparative study of virulence factors among methicillin resistant Staphylococcus aureus clinical isolates (2018)

This study indicates that the detection of fnbA and fnbB contributing to the first step of biofilm formation has been predictable of high biofilm production. As studied factors contribute to MRSA virulence, this research could be of value in orienting towards the development of new preventive and therapeutic measures.
Elasto-acoustic properties of ReCa<inf>4</inf>O(BO<inf>3</inf>)<inf>3</inf> (Re=La, Pr, Nd, Y, Gd) piezoelectric crystals (2011)

Oxyborate single crystals, ReCa <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> O(BO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ) <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (Re=La, Pr, Nd, Y. Gd), have recently been demonstrated to offer superior dielectric, piezoelectric and electromechanical properties to quartz, langasite and other commonly used piezoelectric crystals. Of particular significance is the ability to function at temperatures > 1000°C, offering the potential for SAW, BAW and related sensors operational in harsh environments. In this work, the elasto-acoustic properties of oxyborate crystals were investigated as a function of rare earth cation. Crystallographic relationships were determined to be related to bond length and dependence of cation ordering, which was also reflected in the mechanical loss. Parameters related to high temperature operation, including electrical resistivity, dielectric loss, together with temperature dependent electromechanical and elastic properties were determined and discussed in relation to various applications.
[Transarterial immuno-chemotherapy including adoptive transfer of autologous cultured lymphocytes for stage IV breast cancer patients with locally-advanced tumor]. (1993)

Immuno-chemotherapy via a catheter in the subclavian artery using sequential treatment with OK-432, chemotherapeutic agents (ADM, 5-FU), and cultured autologous lymphocytes, was performed for 9 Stage IV breast cancer patients with locally-advanced primary tumor. Tumor reduction of more than 50% was observed in 8 patients including 4 whose breast tumors had disappeared. Among 11 evaluable distant metastatic lesions, 7 (1 pleural effusion, 2 lung, 2 liver, 2 bone metastases) regressed after local immunotherapy of breast or additional regional immunotherapy (1 lung, 1 liver, 1 pleural effusion). Median survival time to date is 56 months. Five patients are currently alive, although 3 of them did not undergo mastectomy. Local immuno-chemotherapy may be useful because (a) toxicity is limited, (b) low doses of anti-cancer agents during the therapy (median dose of ADM, 60 mg) do not limit subsequent systemic chemotherapy, and (c) distant metastases often regress concomitantly with the primary lesions.
Combining radiationless interference with evanescent field amplification (2010)

The conventional approach for radiationless interference exploits the interference of evanescent components for the purpose of deep-subwavelength focusing and image formation. As a result, deep subwavelength feature size is achieved at the price of severe exponential decay of the field strength. We propose to overcome the limitation of the conventional approach by combining radiationless interference with evanescent field amplification as provided by the surface polaritons at the interface between positive- and negative-dielectric materials. Our approach removes the exponential decay and, moreover, allows a much wider range of wave vectors, including both propagating and evanescent field components, to participate in the image-formation process.
Serotonin and human immunodeficiency viruses. (1989)

This preliminary study shows, for the first time to our knowledge, decreased whole blood serotonin levels in AIDS patients as compared to healthy controls and cancer patients. The lowest serotonin levels were found in AIDS patients with neuropsychiatric symptoms. Finally the present data suggest an inverse relationship between serotonin level and AIDS severity.
The Schizosaccharomyces pombe S-Phase Checkpoint Differentiates Between Different Types of DNA Damage (1998)

We have identified an S-phase DNA damage checkpoint in Schizosaccharomyces pombe. This checkpoint is dependent on Rad3, the S. pombe homolog of the mammalian ATM/ATR checkpoint proteins, and Cds1. Cds1 had previously been believed to be involved only in the replication checkpoint. The requirement of Cds1 in the DNA damage checkpoint suggests that Cds1 may be a general target of S-phase checkpoints. Unlike other checkpoints, the S. pombe S-phase DNA damage checkpoint discriminates between different types of damage. UV-irradiation, which causes base modification that can be repaired during G1 and S-phase, invokes the checkpoint, while gamma-irradiation, which causes double-stranded breaks that cannot be repaired by a haploid cell if induced before replication, does not invoke the checkpoint. Because the same genes are required to respond to UV- and gamma-irradiation during G2, this discrimination may represent an active suppression of the gamma response during S-phase.
Electrotransformation of the Spirochete Borrelia burgdorferi (2003)

Borrelia burgdorferi is an etiologic agent of Lyme disease, the most common arthropod-borne disease in the United States (,). The bacterium, a member of the spirochete phylum, has a genome predominantly composed of linear DNA molecules (,). Formulating a medium in which B. burgdorferi grows in vitro was the first step toward a genetic understanding of the physiology and pathogenesis of the organism (,). The growth of B. burgdorferi as single colonies in solid medium (, , ) has facilitated mutant isolation by selection (,), although a defined medium for selection of auxotrophs is not currently available. The transformation system described in this chapter will be useful for manipulating the spirochete on a molecular genetic level.
Restoring the balance between stuff and things in scene understanding (2018)

Scene understanding is a central field in computer vision that attempts to detect objects in a scene and reason about their spatial, functional and semantic relations. While many works focus on things (objects with a well-defined shape), less attention has been given to stuff classes (amorphous background regions). However, stuff classes are important as they allow to explain many aspects of an image, including the scene type, thing classes likely to be present and physical attributes of all objects in the scene. The goal of this thesis is to restore the balance between stuff and things in scene understanding. In particular, we investigate how the recognition of stuff differs from things and develop methods that are suitable to deal with both. We use stuff to find things and annotate a large-scale dataset to study stuff and things in context. First, we present two methods for semantic segmentation of stuff and things. Most methods require manual class weighting to counter imbalanced class frequency distributions, particularly on datasets with stuff and thing classes. We develop a novel joint calibration technique that takes into account class imbalance, class competition and overlapping regions by calibrating for the pixel-level evaluation criterion. The second method shows how to unify the advantages of region-based approaches (accurately delineated object boundaries) and fully convolutional approaches (end-to-end training). Both are combined in a universal framework that is equally suitable to deal with stuff and things. Second, we propose to help weakly supervised object localization for classes where location annotations are not available, by transferring things and stuff knowledge from a source set with available annotations. This is particularly important if we want to scale scene understanding to real-world applications with thousands of classes, without having to exhaustively annotate millions of images. Finally, we present COCO-Stuff – the largest existing dataset with dense stuff and thing annotations. Existing datasets are much smaller and were made with expensive polygon-based annotation. We use a very efficient stuff annotation protocol to densely annotate 164K images. Using this new dataset, we provide a detailed analysis of the dataset and visualize how stuff and things co-occur spatially in an image. We revisit the question whether stuff or things are easier to detect and which is more important based on visual and linguistic analysis.
Cytokine regulation of metalloproteinase gene expression (1993)

Matrix metalloproteinases belong to a family of zinc-dependent enzymes capable of degrading extracellular matrix and basement membrane components. Their expression is greatly modulated by cytokines and growth factors and involves the gene products of the Fos and Jun families of oncogenes. After extra(peri)cellular activation, their activity can be further controlled by specific tissue inhibitors of metalloproteinases. A correct balance between these regulatory mechanisms is necessary to ensure matrix remodeling in normal physiological processes such as embryonic development, but the overexpression of these enzymes may initiate or contribute to pathological situations such as cartilage degradation in rheumatoid arthritis or to tumor progression and metastasis. Delineation of the mechanisms of metalloproteinase and metalloproteinase inhibitors gene expression, understanding of their mode of interactions, and characterization of their patterns of expression in various tissues in normal and pathological states will lead to new therapeutic strategies to counteract the deleterious effects of matrix metalloproteinases in human disease.
Eliminating microchannel plate response to scattered laser light in a multiphoton ionization experiment (1994)

A simple technique is demonstrated for preventing microchannel plate (MCP) response to scattered laser light in a multiphoton ionization experiment. The MCP is gated on after the laser pulse, with a turn-on time of less than 1 μs, by switching its cathode from 0 to −1900 V. The high-voltage pulse circuit uses power MOSFETs and was designed according to the procedure of Baker and Johnson [Electron. Lett. 29, 56 (1993)].
Electrowinning of Non‐Noble Metals with Simultaneous Hydrogen Evolution at Flow‐Through Porous Electrodes: I . Theoretical (1995)

A mathematical model, is developed to simulate the electrowinning of non‐noble metals (e.g., Zn, Cr) within flow‐through porous electrodes under the conditions of simultaneous evolution of hydrogen gas bubbles. The results of the model are presented as a function of several dimensionless groups representing kinetics, mass transfer, ohmic resistance, and gas bubbles. These coupled, nonlinear effects are investigated by examining the distributions of the metal reduction and hydrogen evolution currents, coulombic efficiency of the metal electrowinning reaction, and gas void fractions under a series of limiting conditions. The gas bubbles accentuate the nonuniform distribution of the potential and the currents of both reactions by increasing the effective resistance of the gas‐electrolyte dispersion filling the pore space. This results in the underutilization of the internal surface area of the porous electrode and accelerates preferential localized plugging of the pores with the reduced metal. It can also instigate localized mass‐transfer limitations, i.e., the polarization at some points within the pores becomes large enough to support the limiting current of the metal deposition reaction (i.e., it becomes mass‐transfer controlled) while at other points lower polarizations and hence smaller currents prevail. Consequently, the optimum current which maximizes the removal rate of the metal is shown to be well below the theoretical limiting current of the electrode. This optimum current is significantly influenced by the evolving hydrogen gas bubbles. Neglecting this phenomenon leads to erroneous design and operational considerations.
ELECTROMAGNETIC WAVES UNDER SEA: BOW-TIE ANTENNAS DESIGN FOR WI-FI UNDERWATER COMMUNICATIONS (2015)

In this paper the propagation of electromagnetic waves in a medium with non zero conductivity is discussed, analyzing the dielectric properties of the sea water, in order to accurately characterize a wireless communication channel. Mathematical models for sea water dielectric constant, wavelength, propagation speed and path loss when an electromagnetic wave at 2.4 GHz propagates through sea water are presented. A Bow-Tie microstrip antenna that is required to overcome the high path loss and bandwidth requirements in sea water is studied. A dual-band antenna, with arc- shaped circular slots, operating for IEEE802.11 b/g/n standards, at 2.4 GHz and 5.1 GHz for WLAN communications, with dimensions 1.4 cm 2 is implemented. Return loss, input impedance and gain have been extracted in order to characterize antennas' performance in a conductive medium.
New Potential Therapeutic Approach for the Treatment of B-Cell Malignancies Using Chlorambucil/Hydroxychloroquine-Loaded Anti-CD20 Nanoparticles (2013)

Current B-cell disorder treatments take advantage of dose-intensive chemotherapy regimens and immunotherapy via use of monoclonal antibodies. Unfortunately, they may lead to insufficient tumor distribution of therapeutic agents, and often cause adverse effects on patients. In this contribution, we propose a novel therapeutic approach in which relatively high doses of Hydroxychloroquine and Chlorambucil were loaded into biodegradable nanoparticles coated with an anti-CD20 antibody. We demonstrate their ability to effectively target and internalize in tumor B-cells. Moreover, these nanoparticles were able to kill not only p53 mutated/deleted lymphoma cell lines expressing a low amount of CD20, but also circulating primary cells purified from chronic lymphocitic leukemia patients. Their safety was demonstrated in healthy mice, and their therapeutic effects in a new model of Burkitt's lymphoma. The latter serves as a prototype of an aggressive lympho-proliferative disease. In vitro and in vivo data showed the ability of anti-CD20 nanoparticles loaded with Hydroxychloroquine and Chlorambucil to increase tumor cell killing in comparison to free cytotoxic agents or Rituximab. These results shed light on the potential of anti-CD20 nanoparticles carrying Hydroxychloroquine and Chlorambucil for controlling a disseminated model of aggressive lymphoma, and lend credence to the idea of adopting this therapeutic approach for the treatment of B-cell disorders.
Spatially-aware adaptive error correcting codes for flash memory (2011)

Motivated by new storage technologies where the errors in data writing and retention tend to be of limited magnitude and localized, we present new code constructions capable of correcting limited-magnitude asymmetric errors that are within pairwise bounded distance of each other. To account for the dynamic nature of the errors across a Flash device's lifetime, another construction is given that corrects unidirectional errors. The proposed constructions offer substantial savings in rate over the conventional error correction schemes, and are particularly amenable for emerging dense storage technologies such as Flash.
The impact of hyper-threading on processor resource utilization in production applications (2011)

Intel provides Hyper-Threading (HT) in processors based on its Pentium and Nehalem micro-architecture such as the Westmere-EP. HT enables two threads to execute on each core in order to hide latencies related to data access. These two threads can execute simultaneously, filling unused stages in the functional unit pipelines. To aid better understanding of HT-related issues, we collect Performance Monitoring Unit (PMU) data (instructions retired; unhalted core cycles; L2 and L3 cache hits and misses; vector and scalar floating-point operations, etc.). We then use the PMU data to calculate a new metric of efficiency in order to quantify processor resource utilization and make comparisons of that utilization between single-threading (ST) and HT modes. We also study performance gain using unhalted core cycles, code efficiency of using vector units of the processor, and the impact of HT mode on various shared resources like L2 and L3 cache. Results using four full-scale, production-quality scientific applications from computational fluid dynamics (CFD) used by NASA scientists indicate that HT generally improves processor resource utilization efficiency, but does not necessarily translate into overall application performance gain.
On the design of planar microwave components using multilayer structures (1992)

The design of planar microwave components using multilayer configurations with potentially arbitrary numbers of dielectric layers and metallization planes is described. Analysis and design are based on a combination of a spectral domain immittance matrix approach and standard CAD methods. To verify the design procedure, three examples-microstrip-slot-line-microstrip transition, a stripline band-pass filter, and a microstrip coupler with lines on different sides of a common ground plane-are investigated theoretically and experimentally.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Don't look stupid (2006)

If recommenders are to help people be more productive, they need to support a wide variety of real-world information seeking tasks, such as those found when seeking research papers in a digital library. There are many potential pitfalls, including not knowing what tasks to support, generating recommendations for the wrong task, or even failing to generate any meaningful recommendations whatsoever. We posit that different recommender algorithms are better suited to certain information seeking tasks. In this work, we perform a detailed user study with over 130 users to understand these differences between recommender algorithms through an online survey of paper recommendations from the ACM Digital Library. We found that pitfalls are hard to avoid. Two of our algorithms generated 'atypical' recommendations recommendations that were unrelated to their input baskets. Users reacted accordingly, providing strong negative results for these algorithms. Results from our 'typical' algorithms show some qualitative differences, but since users were exposed to two algorithms, the results may be biased. We present a wide variety of results, teasing out differences between algorithms. Finally, we succinctly summarize our most striking results as "Don't Look Stupid" in front of users.
Predicting Stability of Gasolines to Aging (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPredicting Stability of Gasolines to AgingCarl Winning and R. M. ThomasCite this: Ind. Eng. Chem. 1933, 25, 5, 511–516Publication Date (Print):May 1, 1933Publication History Published online1 May 2002Published inissue 1 May 1933https://pubs.acs.org/doi/10.1021/ie50281a009https://doi.org/10.1021/ie50281a009research-articleACS PublicationsRequest reuse permissionsArticle Views16Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Epidermal Growth Factor Receptor Juxtamembrane Domain Has Multiple Basolateral Plasma Membrane Localization Determinants, Including a Dominant Signal with a Polyproline Core (2002)

The epidermal growth factor (EGF) receptor is located predominantly in the basolateral membrane of polarized epithelia, where it plays a pivotal role during organogenesis and tissue homeostasis. We have shown previously that a 22-amino acid sequence in the EGF receptor juxtamembrane domain contains autonomous sorting information necessary for basolateral localization using the Madin-Darby canine kidney epithelial cell model. The goal of this study was to determine the molecular basis of EGF receptor basolateral membrane expression using site-directed mutagenesis to modify specific residues in this region. We now show that this sequence has two different, functionally redundant basolateral sorting signals with distinct amino acid requirements: one dependent on residues (658)LL(659) conforming to well-characterized leucine-based sorting signals, and a second containing a polyproline core comprising residues Pro(667) and Pro(670) ((667)PXXP(670)). Our data also suggest that Arg(662) contributes to the function of the proline-based signal. (667)PXXP(670) was the dominant signal when both motifs were present and was more effective than (658)LL(659) at overriding strong apical sorting signals located in the same molecule. Site-directed mutations at Arg(662), Pro(667), and Pro(670) were also associated with increased apical expression of full-length EGF receptors, demonstrating for the first time that the juxtamembrane region is necessary for accurate polarized expression of the native molecule.
Presumptive Identification of Clostridium difficile Strain 027/NAP1/BI on Cepheid Xpert: Interpret with Caution (2011)

The prevalence of hospital- and community-acquired Clostridium difficile infection (CDI) has recently increased, particularly in the Northern Hemisphere, with spread of the hypervirulent 027/NAP/BI strain; so far, this strain is uncommon in Australia. Rapid, accurate laboratory diagnosis of CDI
Distributed submesh determination in faulty tori and meshes (2002)

Torus/mesh-based machines have received increasing attention. It is natural to identify the maximum healthy submeshes in a faulty torus/mesh so as to lower potential performance degradation, because the time for executing a parallel algorithm tends to depend on the size of the assigned submesh. This paper proposes an efficient approach for identifying all the maximum healthy submeshes present in a faulty torus/mesh. The proposed approach is based on manipulating set expressions, with the search space reduced considerably by taking advantage of the interesting properties of a faulty torus/mesh.