gebhart/patrepeval huggingface dataset:
Use of Pimecrolimus Cream in Disorders Other than Atopic Dermatitis (2008)

Background: Pimecrolimus is indicated for treatment of atopic dermatitis and has been evaluated in many other disorders. Objective: To review the efficacy of pimecrolimus in treatment of disorders other than atopic dermatitis. Methods: We performed a PubMed search of the English-language literature using the key word “pimecrolimus.” We reviewed articles reporting the use of pimecrolimus in disorders other than atopic dermatitis and classified them by the type of study used to evaluate efficacy. Results: Randomized, double-blind studies have shown that pimecrolimus is superior to vehicle in treatment of seborrheic dermatitis, hand dermatitis, and asteatotic eczema but have yielded conflicting results regarding intertriginous psoriasis and vitiligo. Open-label studies involving four or more patients have shown favorable results in many disorders, including contact dermatitis, rosacea, lichen sclerosus, and oral and genital lichen planus. Case reports have shown that topical pimecrolimus may be useful in cutaneous graft-versus-host disease, lichen striatus, cutaneous lichen planus, and many other disorders. Conclusions: Topical pimecrolimus appears to be an effective treatment for many disorders other than atopic dermatitis, especially seborrheic dermatitis, hand dermatitis, and asteatoic eczema. It may be effective in many other disorders, but its role in these disorders remains to be clarified by additional studies.
Confirmación molecular de especie en especímenes Anopheles recolectados en el corregimiento de Juan José, Puerto Libertador, Córdoba, Colombia (2012)

Introducc ion La dificultad en la identificacion morfologica de las hembras de varias especies del subgenero Nyssorhynchus ha sido documentada y se debe a la similitud morfologica interespecie, variacion intraespecifica y la existencia de especies cripticas. Por ello, se han utilizado pruebas moleculares como la PCR-RFLP-ITS2, que permiten confirmar la identidad de las especies presentes en regiones endemicas. Objetivo Confirmar la identificacion de mosquitos del genero Anopheles recolectados en Juan Jose, Puerto Libertador, Cordoba, como aporte a un inventario de especies en la localidad. Materiales y metodos De 2.070 hembras de Anopheles identificados por caracteres morfologicos, 513 (24,8%) se confirmaron molecularmente mediante una PCR-RFLP-ITS2. Resultados Las especies identificadas por morfologia presentes en Juan Jose fueron: Anopheles (Nyssorhynchus) nuneztovari s.l. Gabaldon (97,44%), Anopheles (Nys.) darlingi Root (0,77%) y Anopheles (Nys.) oswaldoi s.l. Peryassu (0,10%); el resto de especimenes (1,69%) se definieron como pertenecientes a una de las especies del grupo Oswaldoi. La confirmacion molecular permitio determinar la presencia de solo dos especies entre los especimenes analizados, 99,23% A. (Nys.) nuneztovari s.l. y 0,77% A. (Nys.) darlingi. Conclusion Las dos especies de Anopheles encontradas en Juan Jose, durante el muestreo, son consideradas vectores primarios en Colombia; esta informacion es importante para dirigir los esfuerzos de control vectorial. Adicionalmente, los resultados reiteran previos reportes sobre la dificultad en la identificacion morfologica de A. nuneztovari s.l. y la importancia de utilizar pruebas moleculares en su confirmacion de especie.
Conversion of xylan to ethanol by ethanologenic strains of Escherichia coli and Klebsiella oxytoca (1992)

A two-stage process was evaluated for the fermentation of polymeric feedstocks to ethanol by a single, genetically engineered microorganism. The truncated xylanase gene (xynZ) from the thermophilic bacterium Clostridium thermocellum was fused with the N terminus of lacZ to eliminate secretory signals. This hybrid gene was expressed at high levels in ethanologenic strains of Escherichia coli KO11 and Klebsiella oxytoca M5A1(pLOI555). Large amounts of xylanase (25 to 93 mU/mg of cell protein) accumulated as intracellular products during ethanol production. Cells containing xylanase were harvested at the end of fermentation and added to a xylan solution at 60 degrees C, thereby releasing xylanase for saccharification. After cooling, the hydrolysate was fermented to ethanol with the same organism (30 degrees C), thereby replenishing the supply of xylanase for a subsequent saccharification. Recombinant E. coli metabolized only xylose, while recombinant K. oxytoca M5A1 metabolized xylose, xylobiose, and xylotriose but not xylotetrose. Derivatives of this latter organism produced large amounts of intracellular xylosidase, and the organism is presumed to transport both xylobiose and xylotriose for intracellular hydrolysis. By using recombinant M5A1, approximately 34% of the maximal theoretical yield of ethanol was obtained from xylan by this two-stage process. The yield appeared to be limited by the digestibility of commercial xylan rather than by a lack of sufficient xylanase or by ethanol toxicity. In general form, this two-stage process, which uses a single, genetically engineered microorganism, should be applicable for the production of useful chemicals from a wide range of biomass polymers.
Synthesis of MIL‐100(Fe) at Low Temperature and Atmospheric Pressure (2013)

MIL‐100(Fe), a mesoporous metal‐organic framework (MOF), has a large BET specific surface area and pore volume with the presence of a significant amount of accessible Lewis acid metal sites upon dehydration. The structural characteristics of MIL‐100(Fe) make it a good candidate for potential applications in gas storage, separation, and heterogeneous catalysis. Mainly, this MOF is obtained by the hydrothermal synthesis in a Teflon‐lined autoclave at high temperature (>150°C) under static conditions. However, this method has several disadvantages such as high temperature, high (autogenous) pressure, long time, and comparable low MOF yield. Therefore, development of a facile method for synthesis of MIL‐100(Fe) is vitally important for fundamental understanding and practical application. Herein, MIL‐100(Fe) is synthesized by a facile low‐temperature (<100°C) synthesis route at atmospheric pressure by reaction of metallic iron and trimesic acid in water. Due to our synthesis is conducted with agitation, higher MOF yield (>90%) still could be achieved, suggesting that this simple and energy saving method has the potential to be used practically.
A New Green Ionic Liquid-Based Corrosion Inhibitor for Steel in Acidic Environments (2015)

This work examines the use of new hydrophobic ionic liquid derivatives, namely octadecylammonium tosylate (ODA-TS) and oleylammonium tosylate (OA-TS) for corrosion protection of steel in 1 M hydrochloric acid solution. Their chemical structures were determined from NMR analyses. The surface activity characteristics of the prepared ODA-TS and OA-TS were evaluated from conductance, surface tension and contact angle measurements. The data indicate the presence of a double bond in the chemical structure of OA-TS modified its surface activity parameters. Potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) measurements, scanning electron microscope (SEM), Energy dispersive X-rays (EDX) analysis and contact angle measurements were utilized to investigate the corrosion protection performance of ODA-TS and OA-TS on steel in acidic solution. The OA-TS and ODA-TS compounds showed good protection performance in acidic chloride solution due to formation of an inhibitive film on the steel surface.
All-small-molecule organic solar cells based on an electron donor incorporating binary electron-deficient units (2016)

A conjugated small molecule incorporating binary electron-deficient units was applied in all-small-molecule organic solar cells using fullerene or non-fullerene derivatives as the electron acceptor.
Query by Browsing: An Alternative Hypertext Information Retrieval Method. (1989)

In this paper we discuss our efforts to develop programs which enhance the ability to navigate through large medical hypertext systems. Our approach organizes hypertext index terms into a belief network and uses reader feedback to update the degree of belief in the index terms' utility to a query. We begin by describing various possible configurations for indexes to hypertext. We then describe how belief network calculations can be applied to these indexes. After a brief discussion of early results using manuscripts from a medical handbook, we close with an analysis of our approach's applicability to a wider range of hypertext information retrieval problems.
Marked improvement in delirium with ramelteon: five case reports (2012)

Delirium is a common and serious acute neuropsychiatric syndrome characterized by inattention and global cognitive dysfunction. Delirium is associated with higher morbidity, higher mortality and longer hospitalization, but its aetiology remains unclear. We successfully treated five cases of delirium within 1 day with ramelteon, a novel selective melatonin receptor agonist. This suggests that correction of the circadian rhythm disturbance, one of the main symptoms of delirium, plays a crucial role in its treatment and sheds new light on a therapeutic strategy for treatment of delirium.
Effect of Domain and Circuit Properties on Oscillations in GaAs (1966)

A discussion is given of the complications obtaining when a bar of GaAs, generating microwave oscillations, is allowed to interact with an external circuit. Three very different modes of operation can be expected, each corresponding to a mechanism of extinction of the travelling domains of electric field that cause the current modulation. It is seen that the domains may be extinguished (1) when they reach the end of the bar, (2) when the voltage drops too low for the stability of a domain, or (3) when it rises too high. In the last two circumstances, the external circuit plays an important role. Conditions for the existence of the various modes are deduced, and their properties are studied experimentally.
Query execution for large relations on functional disk system (2003)

The second version of FDS-R (functional disk system with relational database engine), FDS-RII, which is designed to handle large relations efficiently, is discussed. On FDS-RII, the processing algorithm is selected at run time from two algorithms (nested loop algorithms, grace hash algorithm) by comparing their estimated I/O costs. The processing strategy is discussed in detail. The I/O cost formula is examined by measuring the execution time of a join query on the FDS-RII. With the expanded version of Wisconsin Benchmark, the performance of FDS-RII is measured. FDS-RII attained a high performance level for large relations as compared to other large database systems such as Gamma and Teradata. While FDS uses just one disk and three MC68020s, Teradata uses 40 disks and 20 AMPs and Gamma requires eight disks and 17 VAX 11/750s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Horizontal Transfer of Bacterial Symbionts: Heritability and Fitness Effects in a Novel Aphid Host (2005)

Members of several bacterial lineages are known only as symbionts of insects and move among hosts through maternal transmission. Such vertical transfer promotes strong fidelity within these associations, favoring the evolution of microbially mediated effects that improve host fitness. However, phylogenetic evidence indicates occasional horizontal transfer among different insect species, suggesting that some microbial symbionts retain a generalized ability to infect multiple hosts. Here we examine the abilities of three vertically transmitted bacteria from the Gammaproteobacteria to infect and spread within a novel host species, the pea aphid, Acyrthosiphon pisum. Using microinjection, we transferred symbionts from three species of natural aphid hosts into a common host background, comparing transmission efficiencies between novel symbionts and those naturally infecting A. pisum. We also examined the fitness effects of two novel symbionts to determine whether they should persist under natural selection acting at the host level. Our results reveal that these heritable bacteria vary in their capacities to utilize A. pisum as a host. One of three novel symbionts failed to undergo efficient maternal transmission in A. pisum, and one of the two efficiently transmitted bacteria depressed aphid growth rates. Although these findings reveal that negative fitness effects and low transmission efficiency can prevent the establishment of a new infection following horizontal transmission, they also indicate that some symbionts can overcome these obstacles, accounting for their widespread distributions across aphids and related insects.
Multiple Distributed Generators for Distribution Feeder Voltage Support (2005)

Inclusion of voltage support distributed generation (VSDG) can reinforce the feeder voltage of distribution networks, especially in rural/remote areas where voltage dip and frequent blackouts are significant concerns for power utilities. However, installation of multiple distributed generators within a distribution grid system may introduce technical problems in network operation and control, including control interaction and/or voltage instability. This paper addresses the network issues that may occur during multiple VSDG inclusion in the network and presents analytical models and solutions to develop design criteria of VSDG installation in the networks. Voltage sensitivity of lines is investigated and the effect of DG real (P) and reactive (Q) power injections with Q priority is developed for optimal use of VSDG in correcting the network voltage. Interaction among VSDG controllers has been explored and a generalized model is presented to analyze this interaction between any number of VSDGs in the network. The model is tested on a sample VSDG system and test results are presented. The issue of which VSDG must be started recognizing the costs of starting is addressed using an inverse definite minimum time (IDMT) model. A prioritization and coordination scheme for start discrimination of multiple VSDGs is proposed which avoids hunting between multiple generators. 2005 IEEE.
Nisin Resistance in Clostridium botulinum Spores and Vegetative Cells (1997)

The frequencies at which vegetative cells and spores of Clostridium botulinum strains 56A, 62A, 17409A, 25763A, 213B, B-aphis, and 169B formed colonies on agar media containing 0, 10(sup2), 10(sup3), and 10(sup4) IU of nisin per ml at 30(deg)C were determined. Strain 56A had the highest frequencies of nisin resistance, while strains 62A, 169B, and B-aphis had the lowest. For most strains, spores were more resistant than vegetative cells. One exposure to nisin was sufficient to generate stable nisin-resistant isolates in some strains. Stepwise exposure to increasing concentrations of nisin generated stable resistant isolates from all strains. Spores produced from nisin-resistant isolates maintained their nisin resistance. The frequency of spontaneous nisin resistance was reduced considerably by lowering the pH of the media and adding 3% NaCl. Nisin-resistant isolates of strains 56A and 169B also had increased resistance to pediocin PA1, bavaricin MN, plantaricin BN, and leuconocin S.
Polyether biosynthesis. 2. Origin of the oxygen atoms of monensin A (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolyether biosynthesis. 2. Origin of the oxygen atoms of monensin ADavid E. Cane, Tzyy Chyau Liang, and Heinz HaslerCite this: J. Am. Chem. Soc. 1982, 104, 25, 7274–7281Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/ja00389a060https://doi.org/10.1021/ja00389a060research-articleACS PublicationsRequest reuse permissionsArticle Views342Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inflatable Cylinders for Deployable Space Structures (2013)

Inflatable space structures offer the prospect of compact stowed large light-weight structures, which can be inflated to their full dimensions once in space. After inflation the structures may be rigidised to ensure long term structural performance without the need to maintain the internal pressure. Inflatable cylindrical booms are an important category of space inflatable, and often form the structural members of larger structures. A promising method of compactly packaging inflatable cylindrical booms is the use of origami fold patterns. The geometry of the selected fold pattern affects the deployment characteristics of the boom. By modeling the fold pattern as a mechanism of hinged plates, a simple geometric incompatibility can be taken as a measure of the material strains during deployment; this approach enables the initial selection of suitable fold patterns. A series of experiments is set up to investigate the efficacy of the strain-rigidisation of the aluminium-laminate material used for the inflatable cylinders, and study the deployment characteristics of different cylindrical fold patterns. The work in this paper forms part of the InflateSail project to design a large inflatable satellite de-orbiting device to be launched on a 3U CubeSat.
Statistical and visual differentiation of subcellular imaging (2009)

The aim here is to establish a methodology and protocol for testing for difference in subcellular imaging, and to provide tools to do so. While iCluster is applicable to moderate (<1000) size image sets, the statistical test is simple to implement and will readily be adapted to high throughput pipelines to provide more sensitive discrimination of difference.
A 30 kb deletion within the elastin gene results in familial supravalvular aortic stenosis (1995)

Journal Article A 30 kb deletion within the elastin gene results in familial supravalvular aortic stenosis Get access Timothy M. Olson, Timothy M. Olson 1Department of Laboratory Medicine and Pathology2Section of Pediatric Cardiology Search for other works by this author on: Oxford Academic PubMed Google Scholar Virginia V. Michels, Virginia V. Michels 3Department of Medical Genetics, Mayo ClinicRochester, Minnesota 55905 Search for other works by this author on: Oxford Academic PubMed Google Scholar Zsolt Urban, Zsolt Urban 4Department of Surgery, UMDNJ-Robert Wood Johnson Medical SchoolNew Brunswick, New Jersey 08901 Search for other works by this author on: Oxford Academic PubMed Google Scholar Katalin Cslszar, Katalin Cslszar 4Department of Surgery, UMDNJ-Robert Wood Johnson Medical SchoolNew Brunswick, New Jersey 08901 Search for other works by this author on: Oxford Academic PubMed Google Scholar Angela M. Christiano, Angela M. Christiano 5Department of Dermatology, Jefferson Medical CollegePhiladelphia, Pennsylvania, 19107, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar David J. Driscoll, David J. Driscoll 2Section of Pediatric Cardiology Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert H. Feldt, Robert H. Feldt 2Section of Pediatric Cardiology Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles D. Boyd, Charles D. Boyd 4Department of Surgery, UMDNJ-Robert Wood Johnson Medical SchoolNew Brunswick, New Jersey 08901 Search for other works by this author on: Oxford Academic PubMed Google Scholar Stephen N. Thibodeau Stephen N. Thibodeau * 1Department of Laboratory Medicine and Pathology3Department of Medical Genetics, Mayo ClinicRochester, Minnesota 55905 *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 4, Issue 9, September 1995, Pages 1677–1679, https://doi.org/10.1093/hmg/4.9.1677 Published: 01 September 1995 Article history Received: 01 May 1995 Revision received: 01 June 1995 Accepted: 01 June 1995 Published: 01 September 1995
An Effective CU Size Decision Method for HEVC Encoders (2012)

The emerging high efficiency video coding standard (HEVC) adopts the quadtree-structured coding unit (CU). Each CU allows recursive splitting into four equal sub-CUs. At each depth level (CU size), the test model of HEVC (HM) performs motion estimation (ME) with different sizes including 2N × 2N, 2N × N, N × 2N and N × N. ME process in HM is performed using all the possible depth levels and prediction modes to find the one with the least rate distortion (RD) cost using Lagrange multiplier. This achieves the highest coding efficiency but requires a very high computational complexity. In this paper, we propose a fast CU size decision algorithm for HM. Since the optimal depth level is highly content-dependent, it is not efficient to use all levels. We can determine CU depth range (including the minimum depth level and the maximum depth level) and skip some specific depth levels rarely used in the previous frame and neighboring CUs. Besides, the proposed algorithm also introduces early termination methods based on motion homogeneity checking, RD cost checking and SKIP mode checking to skip ME on unnecessary CU sizes. Experimental results demonstrate that the proposed algorithm can significantly reduce computational complexity while maintaining almost the same RD performance as the original HEVC encoder.
Chitosan‐alginate PEC membrane as a wound dressing: Assessment of incisional wound healing (2002)

Flexible, thin, transparent, novel chitosan-alginate polyelectrolyte complex (PEC) membranes, cast from aqueous suspensions of chitosan-alginate coacervates with CaCl(2), were evaluated as potential wound-dressing materials. MTT and NR assays suggested that the chitosan-alginate PEC membranes and their aqueous extracts were nontoxic towards mouse and human fibroblast cells. Cell growth was also not hindered by co-incubation with the membranes. Compared to conventional gauze dressing, the PEC membranes caused an accelerated healing of incision wounds in a rat model. Wounds closed at 14 days postoperatively, and histological observations showed mature epidermal architecture with keratinized surface of normal thickness and a subsided inflammation in the dermis. This was followed by an excellent remodeling phase with organized thicker collagen bundles and mature fibroblasts at 21 days postoperative. Control wounds continued to show signs of an active inflammatory phase under scab on Day 21. Closure rate and appearance of PEC membrane-treated wounds were comparable with Opsite(R)-treated wounds. On the basis of its biocompatibility and wound-healing efficacy, the chitosan-alginate PEC membrane can be considered for wound-dressing applications.
Solid-state power controllers for the next generation (2003)

Real-time solid-state power controllers (SSPCs) are used in the design of the electrical load management center (ELMC). ELMCs which are either centrally or remotely located can achieve the overall system flexibility needed for next-generation complex platforms. The electrical and mechanical features of the SSPC series are discussed, together with military screening, mechanical specifications, and other product options. Power MOSFET circuitry plays a significant role in the direct digital control SSPCs which are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>