gebhart/patrepeval huggingface dataset:
The effect of graded doses of insulin on peripheral glucose uptake and lactate release in cancer cachexia. (1991)

With the euglycemic clamp technique, we evaluated the effects of graded doses of insulin on glucose turnover rates and forearm lactate balance in five weight-losing patients with cancer before surgery and five age- and weight-matched healthy volunteers (control subjects). Insulin was infused sequentially at increasing rates of 0.5 (low physiologic), 1.0 (high physiologic), and 4.0 (supraphysiologic) mU/kg.min for 120 minutes each. Concurrently, rates of glucose appearance and disappearance were derived from [3-3H] glucose infusion. The mean postabsorptive rate of glucose appearance in patients (2.9 +/- 0.1 mg/kg.min) was significantly higher (p less than 0.02) than that of control subjects (1.98 +/- 0.16 mg/kg.min). Complete suppression of endogenous glucose production occurred at high physiologic insulin concentrations. With progressive insulin infusion, the rate of glucose disappearance increased to 3.6 +/- 1.2, 8.7 +/- 0.8, and 13.7 +/- 1.1 mg/kg/min in control subjects and 2.9 +/- 0.4, 5.3 +/- 0.3, and 10.9 +/- 0.9 mg/kg.min in patients, significantly different from that of control subjects (p less than 0.05) during the intermediate (high physiologic) insulin infusion. A comparable slight increase in arterial plasma lactate concentration was observed in both groups with progressive hyperinsulinemia. Baseline peripheral lactate flux was identical in patients (-272 +/- 56 nmol/100 gm.min) and in controls (-271 +/- 57 nmol/100 gm.min). Progressive physiologic hyperinsulinemia resulted in significantly (p less than 0.05) augmented peripheral lactate efflux in patients (-824 +/- 181 nmol/100 gm.min) compared with control subjects (-287 +/- 64 nmol/100 gm.min). Supraphysiologic insulin abolished this increased lactate efflux in patients. Postabsorptive rates of endogenous glucose appearance in weight-losing patients with cancer were elevated, but complete suppression was achieved with insulin concentrations in the physiologic range. Total body glucose use was diminished in these patients, consistent with a state of insulin resistance. This impaired insulin action on peripheral glucose use was associated with an increase in peripheral lactate release in patients.
An Experimental Study of the Permeability to Gases of the Seed-coat Membranes of Cucurbita Pepo (1940)

Journal Article An Experimental Study of the Permeability to Gases of the Seed-coat Membranes of Cucurbita Pepo Get access R. BROWN R. BROWN Research Institute of Plant Physiology, Imperial College of Science and TechnologyLondon Search for other works by this author on: Oxford Academic PubMed Google Scholar Annals of Botany, Volume 4, Issue 2, April 1940, Pages 379–395, https://doi.org/10.1093/aob/4.2.379 Published: 01 April 1940
A novel missense mutation in the factor VIII gene identified by analysis of amplified hemophilia DNA sequences (1987)

To date the only point mutations demonstrated to cause hemophilia are C to T transitions in TaqI sites. These were detected by screening Southern blots with cloned factor VIII probes. During the development of improved methods for detecting and analyzing mutations in genomic DNA, a novel G to C transversion mutation has been identified. This rare transversion results in a missense mutation, with proline being substituted for arginine in one of the active domains of the factor VIII molecule. The results suggest that the improved methods will be useful for detecting mutations in hemophilia as well as in other genetic disorders. In this method, specific DNA sequences in genomic DNA are amplified using oligonucleotide primers and a heat-resistant DNA polymerase. Mutations are detected and localized in the amplified samples by RNase A cleavage, and the altered region is then sequenced.
Bit-level systolic array for FIR filter using AND-based bit-serial multiplier (2004)

The paper proposes a bit-level systolic array for FIR digital filter with an AND-based bit-serial pipelined multiplier inside. Compared to the conventional systolic array for FIR filter based on word-level data flow, the bit-level systolic array for FIR filter is very compact in that it needs only two 1-bit I/O ports in addition to reduced area requirement without time penalty on the output sequence.
Gating the bacterial mechanosensitive channel MscL <i>in</i> <i>vivo</i> (2002)

YggB and MscL are the major mechanosensitive channels in Escherichia coli, and each can rescue the double knockout mutant from osmotic downshock. However, the role of MscL in wild-type bacteria is in question, not only because cells without MscL survive severe osmotic downshocks, but because 1.8 times more suction is required to gate MscL than YggB under patch clamp. Here, we extend previous evidence [Ajouz, B., Berrier, C., Garrigues, A., Besnard, M. & Ghazi, A. (1998) J. Biol. Chem. 273, 26670-26674] to show that downshock gates MscL in vivo even in the presence of YggB. We have made this determination by engineering a channel we can structurally modify in vivo (Leu-19-->Cys MscL). MscLs with charges in their constrictions are known to open easily and transiently to substates and stop cell growth. In this study, we use downshock to stretch this region open to allow attachment of a charged thiosulfonate reagent MTSET(+), thereby creating a toxic channel. Therefore, channel opening can be monitored by loss of colony forming units. By this measure, we find that an approximately 800 mmol/kg downshock from 1,200 mmol/kg medium opens Leu-19-->Cys MscL in the presence of YggB, but a downshock of only approximately 400 mmol/kg is required in the absence of YggB. In parallel, Leu-19-->Cys MscL, stretched open by large sustained suction in the presence of MTSET(+) in voltage-clamped patches, subsequently flickers open with little suction. These observations show that MscL opening is triggered by a specific downshock, even in the presence of YggB, that YggB buffers MscL gating in vivo, and that residue 19 becomes exposed upon channel opening.
Sourdough Technology—A Traditional Way for Wholesome Foods: A Review (2011)

Abstract: In the present era, consumers wish to have a wide range of foods that are nutritious and flavorful and have long shelf life without added preservatives. Sourdough is an important modern fermentation of cereal flours and water based upon an earlier spontaneous process. The sourdough microflora is dominated by lactic acid bacteria and, along with yeast, they play a key role in the fermentation of bread dough. Factors that affect the quality of sourdough are dough yield, temperature, type of starter culture, acidity of the medium, and the substrate. Sourdough is classified into 3 types (Types I, II, and III); the most widely used for commercial production is Type III. The sourdough fermentation has a number of beneficial effects that include prolonged shelf life, accelerated volume gain, delayed staling, improved bread flavor, and good nutritional value. Sourdough also improves sensory characteristics such as loaf volume, evenness of baking, color, aroma, taste, and texture of breads. Sourdough has been reported to contribute to extended shelf life by inhibiting spoilage bacteria and mold growth.
Unified representation of monitoring information across federated cloud infrastructures (2014)

Nowadays one of the issues hindering the potential of federating cloud-based infrastructures to reach much larger scales is their standard management and monitoring. In particular, this is true in cases where these federated infrastructures provide emerging Future Internet and Smart Cities-oriented services, such as the Internet of Things (IoT), that benefit from cloud services. The contribution of this paper is the introduction of a unified monitoring architecture for federated cloud infrastructures accompanied by the adoption of a uniform representation of measurement data. The presented solution is capable of providing multi-domain compatibility, scalability, as well as the ability to analyze large amounts of monitoring data, collected from datacenters and offered through open and standardized APIs. The solution described herein has been deployed and is currently running on a community of 5 infrastructures within the framework of the European Project XIFI, to be extended to 12 more infrastructures.
Region-based Petri nets for modeling interrupts and cancellations (2003)

A synchronization mechanism using asynchronous activation and cancellation is considered. A process can receive asynchronous signals. The signals can either suspend the current activity causing the process to execute a handling procedure, or they can cancel the current computation. The Petri net formalism is employed to describe the behavior of the system. An extension to Color Petri Nets, region based PN, is proposed to model actions effecting a set of places while the exact marking is neither known nor important.
Initial synchronization techniques for antenna arrays in the presence of interference signals (2003)

This paper presents initial synchronization techniques for antenna arrays in the presence of interference signals. When a new desired signal arrives, the timing and frequency synchronization is needed in the beginning of communication. Firstly, we present a simplified signal processing structure with low complexity for timing synchronization. Secondly, a frequency synchronization method is presented for antenna arrays. Thirdly, we improve timing and frequency synchronization using weight computation method with rapid convergence in the presence of continuous interference signals. Numerical results show that our method enables precise initial synchronization for antenna arrays.
Hidden Markov modeling for network communication channels (2001)

In this paper we perform the statistical analysis of an Internet communication channel. Our study is based on a Hidden Markov Model (HMM). The channel switches between different states; to each state corresponds the probability that a packet sent by the transmitter will be lost. The transition between the different states of the channel is governed by a Markov chain; this Markov chain is not observed directly, but the received packet flow provides some probabilistic information about the current state of the channel, as well as some information about the parameters of the model. In this paper we detail some useful algorithms for the estimation of the channel parameters, and for making inference about the state of the channel. We discuss the relevance of the Markov model of the channel; we also discuss how many states are required to pertinently model a real communication channel.
Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome (2022)

Following acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a significant proportion of individuals develop prolonged symptoms, a serious condition termed post-acute coronavirus disease 2019 (COVID-19) syndrome (PACS) or long COVID. Predictors of PACS are needed. In a prospective multicentric cohort study of 215 individuals, we study COVID-19 patients during primary infection and up to one year later, compared to healthy subjects. We discover an immunoglobulin (Ig) signature, based on total IgM and IgG3 levels, which - combined with age, history of asthma bronchiale, and five symptoms during primary infection - is able to predict the risk of PACS independently of timepoint of blood sampling. We validate the score in an independent cohort of 395 individuals with COVID-19. Our results highlight the benefit of measuring Igs for the early identification of patients at high risk for PACS, which facilitates the study of targeted treatment and pathomechanisms of PACS.
Switching in One Monolayer of the Ferroelectric Polymer (2005)

The switching in one monolayer of ferroelectric vinylidene fluoride-trifluoroethylene copolymer P[VDF-TrFE] is observed. The kinetics of switching is well described by Landau-Khalatnikov (LK) equation.
On the Mechanical Stability of lnclined Wellbores (1996)

Summary Consideration of the stress field around an arbitrarily oriented borehole shows that in an extensional stress regime (σv σH&gt;σh), wellbores parallel to the direction of minimum horizontal principal stress are the least prone to compressive shear failure (breakout). The most stable deviation angle (from the vertical) depends on the ratio of the horizontal principal stresses to the vertical stresses, and the higher the ratio σH/σV, the higher the deviation angle for minimizing breakout. In a strike-slip stress regime (σv &lt;σH&gt;σh), horizontal wells are the least prone to breakout, and the higher the ratio σH/σ v, the closer the drilling direction should be to the azimuth of σH. A new compressive shear failure criterion, which is a combination of the effective strength concept and the Drucker-Prager criterion, is proposed for quantifying the stresses at which borehole breakout occurs. The lowest mud weight, at and below which breakout will occur, can be predicted by combining this criterion with the stress field around an arbitrarily oriented borehole. The highest mud weight at and above which a tensional or hydraulic fracture is induced can be predicted by combining the tensile strength of the rocks of the wellbore wall with the stress field around an arbitrarily oriented borehole. For the in-situ stress environments considered, the optimally oriented inclined wellbore is less prone to breakout (i.e., allows a lower mud weight) and tensional or hydraulic fracture (i.e., supports a higher mud weight) than a vertical well.
ChemInform Abstract: Synthesis of 2′‐Deoxy‐β‐D‐ribofuranosyl Imidazole and Thiazole C‐ Nucleosides. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Monte Carlo evaluation of compton scatter compensation by deconvolution in SPECT (1984)

This study evaluates a deconvolution algorithm which compensates for Compton scattering in SPECT images. Using Monte Carlo methods, the scattered and non-scattered components of a SPECT image are simulated thus allowing a comparison of scatter compensated results with direct non-scatter results. This technique is crucial for evaluating compensation algorithms since scattered photons are not distinguished from non-scattered photons experimentally. Compton scatter is modeled as a convolution of the non-scattered projection with an exponential function.
A Strategy to Achieve Efficient Dual‐Mode Luminescence of Eu<sup>3+</sup> in Lanthanides Doped Multifunctional NaGdF<sub>4</sub> Nanocrystals (2010)

A strategy is proposed to fabricate dual-mode luminescent NaGdF4 nanocrystals that are composed of NaGdF4:Yb3+,Tm3+ core and NaGdF4:Eu3+ shell. Intense downconversion via the sensitization of Gd3+ and upconversion luminescence of Eu3+ that is one order of magnitude higher than the triply-doped core only counterparts have been achieved by employing the distinct core/shell nanostructures and double sensitizations of Yb3+ and Tm3+.
Progesterone receptors - animal models and cell signaling in breast cancer Diverse activation pathways for the progesterone receptor - possible implications for breast biology and cancer (2002)

Progesterone and estradiol, and their nuclear receptors, play essential roles in the physiology of the reproductive tract, the mammary gland and the nervous system. Estrogens have traditionally been considered associated with an increased risk of breast cancer. There is, however, compelling evidence that progesterone plays an important role in breast cell proliferation and cancer. Herein, we review the possible role of progestins and the progesterone receptor-associated signaling pathways in the development of breast cancer, as well as the therapeutic possibilities arising from our growing knowledge of the activation of the progesterone receptor by other proliferative mechanisms.
Optimal decision boundaries for M-QAM signal formats using neural classifiers (1998)

The application of neural classifiers for providing optimal decision boundaries of a warped and clustered M-QAM constellation affected by nonlinearity is analyzed in this paper. The classifier behavior, for the specific application, has been evaluated both by the carrier to noise ratio (CNR) degradation (DeltaC/N) due to nonlinearity for a target error rate P(c)=10(-3), and more thoroughly by classical figures of merit of the pattern recognition theory such as classification confidence and generalization capability. The influence of the probability distribution of the training examples and the effects of activation functions' sharpness (namely the temperature of the net) have also been investigated. The results, obtained on a simulation basis, indicate optimal matching with respect to upper bounds evaluated with some minor simplifying hypothesis, even if the overall method's effectiveness can be adequate only for mild nonlinearity conditions.
Effectiveness of silica based sol-gel microencapsulation method for odorants and flavors leading to sustainable environment (2015)

Microencapsulation has become a hot topic in chemical research. Technology mainly used for control release and protection purposes. The sol-gel micro encapsulation approach for fragrance and aroma in porous silica-based materials leads to sustainable odorant and flavored materials with novel and unique beneficial properties. Sol-gel encapsulation of silica based micro particles considered economically cheap as capital investment in manufacturing is very low and environmentally friendly. Amorphous sol-gel SiO2 is non-toxic and safe, whereas the sol-gel entrapment of delicate chemicals in its inner pores results in pronounced chemical and physical stabilization of the entrapped active agents, thereby broadening the practical utilization of chemically unstable essential oils (EOs). Reviewing progress in the fabrication of diverse odorant and flavored sol-gels, shows us how different synthetic strategies are appropriate for practical application with important health and environmental benefits.
The rupture through posterior vaginal fornix of the posterior lower uterine segment (2004)

Uterine rupture during labor, when it is in the immediate vicinity of the cervix, frequently extends transversely or obliquely. Usually the tear is longitudinal when it occurs in the portion of the uterus adjacent to the broad ligament. We report an unusual case of uterine rupture through posterior vaginal fornix of the posterior lower uterine segment.
Tissue Angiotensinogen Gene Expression Induced by Lipopolysaccharide in Hypertensive Rats (1997)

There is now convincing evidence that various tissues express their own tissue renin-angiotensin system, which may be regulated independently of the systemic renin-angiotensin system. However, little information is available on the regulation of the tissue renin-angiotensin system. We investigated the regulation of tissue angiotensinogen gene expression with respect to the development of hypertension. We measured basal and lipopolysaccharide-stimulated plasma angiotensinogen concentrations by radioimmunoassay and examined the expression of tissue angiotensinogen by Northern blot analysis in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) at 4 and 13 weeks of age. Basal plasma angiotensinogen concentration in SHR was comparable to that in WKY at 4 weeks of age and was significantly higher than that in WKY at 13 weeks of age. Lipopolysaccharide induced a significant increase in plasma angiotensinogen concentration in both WKY and SHR at 4 and 13 weeks of age. At 4 weeks of age, the basal levels of angiotensinogen mRNA in the liver, fat, adrenal, and aorta were higher in WKY than in SHR. At 13 weeks of age, the basal levels of angiotensinogen mRNA in the fat, adrenal, aorta, spleen, and kidney were higher in WKY than in SHR, while that in the liver did not differ significantly between the two strains. At 4 weeks of age, pretreatment with lipopolysaccharide increased the angiotensinogen mRNA levels in the liver, fat, adrenal, and aorta in both WKY and SHR. At 13 weeks of age, pretreatment with lipopolysaccharide increased the angiotensinogen mRNA levels in the liver, aorta, and adrenal; decreased those in the spleen; and had no effect in the kidney in both WKY and SHR. Interestingly, lipopolysaccharide increased the angiotensinogen mRNA level in fat only in SHR, with no effect in WKY, at 13 weeks of age. Lipopolysaccharide stimulated tumor necrosis factor-a mRNA expression in fat of WKY and SHR, and the increase in tumor necrosis factor-alpha mRNA level in SHR was significantly greater than that in WKY. Therefore, the increased tumor necrosis factor-alpha mRNA expression may be involved in the increased lipopolysaccharide-induced expression of angiotensinogen gene in fat of SHR at 13 weeks of age. These data suggest that the transcriptional and probably posttranscriptional regulation of angiotensinogen mRNA differs between SHR and WKY, that the regulation of angiotensinogen gene expression is tissue-specific, and that the altered expression of the angiotensinogen gene may be involved in the development of hypertension.
Consensus recommendations for risk stratification in multiple myeloma: report of the International Myeloma Workshop Consensus Panel 2 (2011)

A panel of members of the 2009 International Myeloma Workshop developed guidelines for risk stratification in multiple myeloma. The purpose of risk stratification is not to decide time of therapy but to prognosticate. There is general consensus that risk stratification is applicable to newly diagnosed patients; however, some genetic abnormalities characteristic of poor outcome at diagnosis may suggest poor outcome if only detected at the time of relapse. Thus, in good-risk patients, it is necessary to evaluate for high-risk features at relapse. Although detection of any cytogenetic abnormality is considered to suggest higher-risk disease, the specific abnormalities considered as poor risk are cytogenetically detected chromosomal 13 or 13q deletion, t(4;14) and del17p, and detection by fluorescence in situ hybridization of t(4;14), t(14;16), and del17p. Detection of 13q deletion by fluorescence in situ hybridization only, in absence of other abnormalities, is not considered a high-risk feature. High serum β(2)-microglobulin level and International Staging System stages II and III, incorporating high β(2)-microglobulin and low albumin, are considered to predict higher risk disease. There was a consensus that the high-risk features will change in the future, with introduction of other new agents or possibly new combinations.
Room Reflections Misunderstood (2007)

The papers at this Convention have been selected on the basis of a submitted abstract and extended precis that have been peer reviewed by at least two qualified anonymous reviewers. This convention paper has been reproduced from the author&apos;s advance manuscript, without editing, corrections, or consideration by the Review Board. The AES takes no responsibility for the contents. Additional papers may be obtained by sending request and remittance to Audio Engineering Society, 60 East 42nd Street, New