gebhart/patrepeval huggingface dataset:
The Effect of Activator Concentration on the Infrared-Sensitive Phosphor, Strontium Sulfide—Samarium, Europium<sup>1</sup> (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Effect of Activator Concentration on the Infrared-Sensitive Phosphor, Strontium Sulfide—Samarium, Europium1Kenneth F. Stripp and Roland WardCite this: J. Am. Chem. Soc. 1948, 70, 1, 401–406Publication Date (Print):January 1, 1948Publication History Published online1 May 2002Published inissue 1 January 1948https://pubs.acs.org/doi/10.1021/ja01181a126https://doi.org/10.1021/ja01181a126research-articleACS PublicationsRequest reuse permissionsArticle Views165Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-β (1989)

The binding of three radiolabeled isoforms of platelet-derived growth factor (PDGF), 125I-PDGF-AA, 125I-PDGF-AB, and 125I-PDGF-BB, is differentially affected by exposure of quiescent 3T3 cells to transforming growth factor-beta (TGF-beta). By 24 h after exposure to TGF-beta, binding of 125I-PDGF-AA and 125I-PDGF-AB is almost completely lost, whereas binding of 125I-PDGF-BB is reduced by only 40%. The loss of PDGF-binding sites caused by TGF-beta is time- and concentration-dependent and reflects a change in the pattern of expression of receptor subunits; the number of alpha-subunits decreases, and the number of beta-subunits increases. The loss of binding sites for PDGF-AA is accompanied by a decreased mitogenic response to PDGF-AA but not to PDGF-AB or PDGF-BB. These results suggest that TGF-beta may differentially regulate the expression of PDGF-binding sites and the mitogenic responsiveness toward the three PDGF isoforms. TGF-beta did not stimulate synthesis of PDGF A-chain mRNA or PDGF-AA protein, and PDGF-AA receptors could not be restored by the presence of suramin, suggesting that the loss of binding sites may result from direct effects on receptor expression rather than autocrine down-regulation by PDGF-AA.
Reductase Inhibitor Monotherapy and Stroke Prevention (1997)

Reductase inhibitors now in use for lowering cholesterol levels are more potent and have fewer side effects than the cholesterol-lowering agents previously available. They appear to reduce stroke, most notably in patients with prevalent coronary artery disease, which may be partly due to the effects of lowering the levels of cholesterol on the progression and plaque stability of extracranial carotid atherosclerosis or the marked reduction of incident coronary heart disease associated with treatment.
Automatic Extraction of Musical Structure Using Pitch Class Distribution Features (2006)

Abstract. This paper compares the efficiency of different sets of tonal descriptors in music structural discovery. Herein, we analyze the use of three different pitch-class distribution features, i.e. Constant-Q Profile, Pitch Class Profile (PCP) and Harmonic Pitch Class Profile (HPCP), to perform structural analysis of a piece of music audio. We hypothesize that proper segmentation serves as an important basis to obtain music structure analyses of better quality. Thus, we compare the segmentation results produced by each feature to examine its efficiency. A database of 56 audio files (songs by The Beatles) is used for evaluation. In addition, we also show the validity of the descriptors in our structural description system by comparing its segmentation results with a present approach by Chai [1] using the same database. The experimental results show that the HPCP performs best yielding an average of 82 % of accuracy in identifying structural boundaries in music audio signals.
High-modulus low-linear-expansion-coefficient loose-jacket optical fibers (1984)

Optical fibers loosely jacketed with high-modulus low-linear-expansion-coefficient polymers have been proposed, and the mechanical, thermal, and optical properties have been investigated. The loose-jacket tube is made of highly oriented polyoxymethylene (POM), which is produced by tensile-drawing the isotropic POM tube with dielectric heating. The oriented POM exhibits Young's moduli 20-40 GPa and linear expansion coefficients of the order of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10^{-5}-10^{-6}\deg</tex> C <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> . Owing to the low linear expansion coefficients of the material, the oriented POM loose-jacket optical fiber has no low-temperature excess losses, which is due to fiber bends caused by thermal contraction of the loose tube, in the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-60-80\deg</tex> C temperature range.
Position dependence of functional hairpins important for human immunodeficiency virus type 1 RNA encapsidation in vivo (1997)

At least two hairpins in the 5' untranslated leader region, stem-loops 1 and 3 (SL1 and SL3), contribute to human immunodeficiency virus type 1 RNA encapsidation in vivo. We used a competitive assay, which measures the relative encapsidation efficiency of mutant viral RNA in the presence of competing wild-type RNA, to compare the contributions of SL1, SL3, and two adjacent secondary structures, SL2 and SL4, to encapsidation. SL2 is not required for RNA encapsidation, while SL1, SL3, and SL4 all contribute approximately equally to encapsidation. To determine whether these hairpins function in a position-dependent manner, we interchanged the positions of two of these stem-loop structures. This resulted in substantial diminution of encapsidation, indicating that the secondary structures that comprise E, the encapsidation signal, function only in their correct contexts. Mutation of nucleotides flanking SL1 and SL3 had little effect on encapsidation. We also showed that SL1, while present on both genomic and subgenomic viral RNAs, nonetheless contributes to selective encapsidation of genomic RNA. Taken together, these data are consistent with the formation of a higher-order RNA structure, partially composed of SL1, SL3, and SL4, that functions to effect concurrent encapsidation of full-length RNA and exclusion of subgenomic RNA. Finally, it has been reported that E is required for efficient translation of Gag mRNA in vivo. However, we have found that a variety of mutants, including a mutant lacking the entire region encompassing SL1, SL2, and SL3, still produce RNAs that are efficiently translated. These data indicate that E is unlikely to contribute to efficient Gag mRNA translation in vivo.
Angiotensin II type 1 and 2 receptors and lymphatic vessels modulate lung remodeling and fibrosis in systemic sclerosis and idiopathic pulmonary fibrosis (2013)

We concluded that angiotensin II receptor expression in the lung parenchyma can potentially control organ remodeling and fibrosis, which suggests that strategies aimed at preventing high angiotensin 2 receptor expression may be used as potential therapeutic target in patients with pulmonary systemic sclerosis and idiopathic pulmonary fibrosis.
Molecular Structure and Physiological Functions of GABA<sub>B</sub>Receptors (2004)

GABA(B) receptors are broadly expressed in the nervous system and have been implicated in a wide variety of neurological and psychiatric disorders. The cloning of the first GABA(B) receptor cDNAs in 1997 revived interest in these receptors and their potential as therapeutic targets. With the availability of molecular tools, rapid progress was made in our understanding of the GABA(B) system. This led to the surprising discovery that GABA(B) receptors need to assemble from distinct subunits to function and provided exciting new insights into the structure of G protein-coupled receptors (GPCRs) in general. As a consequence of this discovery, it is now widely accepted that GPCRs can exist as heterodimers. The cloning of GABA(B) receptors allowed some important questions in the field to be answered. It is now clear that molecular studies do not support the existence of pharmacologically distinct GABA(B) receptors, as predicted by work on native receptors. Advances were also made in clarifying the relationship between GABA(B) receptors and the receptors for gamma-hydroxybutyrate, an emerging drug of abuse. There are now the first indications linking GABA(B) receptor polymorphisms to epilepsy. Significantly, the cloning of GABA(B) receptors enabled identification of the first allosteric GABA(B) receptor compounds, which is expected to broaden the spectrum of therapeutic applications. Here we review current concepts on the molecular composition and function of GABA(B) receptors and discuss ongoing drug-discovery efforts.
High Frequency of Occurrence of CYP2D6 Gene Duplication/Multiduplication Indicating Ultrarapid Metabolism Among Suicide Cases (2009)

In Sweden, about 550 individuals die every year of drug intoxication. Many of these drugs are metabolized by CYP enzymes such as CYP2D6 and CYP2C19. A lack of these enzymes, resulting in poor metabolism, can lead to adverse reactions and even to fatality. On the other hand, an ultrarapid metabolism can lead to insufficient drug plasma concentration, resulting in failure of treatment, or it can lead to high concentrations of active/toxic metabolites. The aim of this project was to study the genetic profile of individuals with regard to the presence of CYP2D6 and CYP2C19 genes, in cases of fatal intoxication (242), suicide (intoxications excluded) (262), and natural death (212). PCR, followed by pyrosequencing, was used for all the analyses. We found that, among those who died of suicide (suicide cases), there was a higher number carrying more than two active CYP2D6 genes (corresponding to the phenotype of ultrarapid metabolizer) as compared with those who died of natural causes (natural-death cases) (P = 0.007).
Exercise as a countermeasure for physiological adaptation to prolonged spaceflight (1996)

Exercise represents the primary countermeasure used during spaceflight to maintain or restore maximal aerobic capacity (VO2max), musculoskeletal structure, and orthostatic function. However, no single exercise or combination of prescriptions has proven entirely effective in restoring cardiovascular and musculoskeletal functions to preflight levels following prolonged spaceflight. As human spaceflight exposures increase in duration, assessment and development of various effective exercise-based protective procedures become paramount. This must involve improvement in specific countermeasure prescription as well as development of additional approaches that will allow space travelers greater flexibility and medical safety during long flights. Effective exercise prescription will be based on identification of basic physiological stimuli that maintain normal function in terrestrial gravity and understanding of how specific combinations of exercise characteristics e.g., duration, frequency, intensity, mode) can mimic these stimuli and affect the overall process of adaptation to microgravity. This can be accomplished only with greater emphasis of research on ground-based experiments. Future attention must be directed to improving exercise compliance while minimizing both crew time and the impact of the exercise on life-support resources.
The Role of Dornase Alfa in the Treatment of Cystic Fibrosis (1996)

Objective To review the current utility and proper role of dornase alfa (recombinant human DNase or rhDNase), which has been approved for use in cystic fibrosis. Several aspects related to these issues are addressed including the drug's mechanism of action, administration and dosing, and clinical safety and efficacy. We also critically examine the agent's role in the treatment of cystic fibrosis and consider the controversies involved with its use. data source A MEDLINE search was conducted to identify pertinent literature, including review articles and clinical trials. Study Selection Studies examining the efficacy and safety of dornase alfa in patients with cystic fibrosis. Data Extraction Results from published, prospective, randomized trials are presented and critiqued. Data Synthesis Production of viscous respiratory secretions is a hallmark phenomenon of cystic fibrosis, leading to a variety of symptoms. Dornase alfa targets this symptom and decreases the viscosity of these secretions. Clinical trials have indicated a small but statistically significant improvement in forced expiratory volume in 1 second and forced vital capacity. Enhancement in a patient's dyspnea and quality of life has varied between the trials, with few of the studies noting no statistically significant improvement. Adverse reactions are minimal and did not result in any patient withdrawals from the trials. A positive impact on infection rates, length of hospitalization, and need for intravenous antibiotic therapy was noted in one trial. However, reports of similar results have not yet been published, and thus the clinical significance or impact of this phenomenon is not fully understood. Moreover, results of more long-term use and in patients whose conditions are less stable have yet to undergo the scrutiny of peer/editorial review. Administration of the drug, which must be maintained continuously, is relatively expensive. Conclusions Dornase alfa appears to produce small but sustained improvements in lung function in patients with cystic fibrosis. It may also slow the progression of pulmonary disease. Infection rates appear to be reduced, which may well have important long-term consequences. However, evidence to date has not clarified the most appropriate use of dornase alfa in the treatment of cystic fibrosis. Whether quality of life is affected in a meaningful and measurable way is yet to be clarified. A trial of the drug in patients with cystic fibrosis who have obvious lung disease is reasonable, but continued treatment should be based on clear clinical response. Therefore, questions about the drug's exact role in the overall management of cystic fibrosis remain to be answered. Although benefits received may not prove to be cost-effective, long-term effects on disease progression may well justify use of this agent.
Effect of a Polyphenol-Rich Extract from <i>Aloe vera</i> Gel on Experimentally Induced Insulin Resistance in Mice (2007)

Insulin resistance, which precedes type 2 diabetes mellitus (T2DM), is a widespread pathology associated with the metabolic syndrome, myocardial ischemia, and hypertension. Finding an adequate treatment for this pathology is an important goal in medicine. The purpose of the present research was to investigate the effect of an extract from Aloe vera gel containing a high concentration of polyphenols on experimentally induced insulin resistance in mice. A polyphenol-rich Aloe vera extract (350 mg/kg) with known concentrations of aloin (181.7 mg/g) and aloe-emodin (3.6 mg/g) was administered orally for a period of 4 weeks to insulin resistant ICR mice. Pioglitazone (50 mg/kg) and bi-distilled water were used as positive and negative controls respectively. Body weight, food intake, and plasma concentrations of insulin and glucose were measured and insulin tolerance tests were performed. The insulin resistance value was calculated using the homeostasis model assessment for insulin resistance (HOMA-IR) formula. Results showed that the polyphenol-rich extract from Aloe vera was able to decrease significantly both body weight (p < 0.008) and blood glucose levels (p < 0.005) and to protect animals against unfavorable results on HOMA-IR, which was observed in the negative control group. The highest glucose levels during the insulin tolerance curve test were in the negative control group when compared to the Aloe vera extract and pioglitazone treated mice (p < 0.05). In conclusion, Aloe vera gel could be effective for the control of insulin resistance.
Review of reactive kinetic models describing reductive dechlorination of chlorinated ethenes in soil and groundwater (2012)

Abstract Reductive dechlorination is a major degradation pathway of chlorinated ethenes in anaerobic subsurface environments, and reactive kinetic models describing the degradation process are needed in fate and transport models of these contaminants. However, reductive dechlorination is a complex biological process, where many microbial populations including dechlorinating, fermentative, methanogenic, iron and sulfate reducing, interact. In this article the modeling approaches and the experimental data needed to calibrate them are reviewed, classified, and discussed. Model approaches considered include first order kinetics, Monod kinetics to describe sequential reductive dechlorination and bacterial growth, and metabolic models which simulate fermentation and redox processes interacting with reductive dechlorination processes. The review shows that the estimated kinetic parameters reported vary over a wide range, and that experimental microbial data are scarce. Very few studies have been performed evaluating the influence of sulfate and iron reduction, and contradictory conclusions on the interaction of redox processes with reductive dechlorination have been reported. The modeling approaches for metabolic reductive dechlorination employing different descriptions of the interaction between redox and dechlorination processes and competition for hydrogen are classified. The current concepts lead to different results, suggesting a need for further investigations on the interactions between the microbial communities performing dechlorination and redox processes, including the establishment of biomarkers quantifying dechlorination, and on geochemical characterization. Finally, the relevance of laboratory data and the development of practical modeling tools for field applications are discussed. Biotechnol. Bioeng. 2013; 110: 1–23. © 2012 Wiley Periodicals, Inc.
Dimethylsulfonium and thiolanium analogs of the muscarinic agent oxotremorine (1988)

Dimethylsulfonium (6a and 6b) and thiolanium analogues (7a and 7b) of oxotremorine were synthesized and found to be potent muscarinic agents in vivo and vitro. Compound 6a exceeded oxotremorine in potency. Their affinities for muscarinic receptors in the guinea pig ileum and urinary bladder, estimated pharmacologically, were higher than those of the corresponding trimethylammonium (8a and 8b) and N-methylpyrrolidinium compounds (9a and 9b). However, the new compounds had lower intrinsic efficacies than their quaternary ammonium analogues. The compounds also had high affinity for central muscarinic receptors as measured by displacement of specifically bound (-)-[3H]-N-methylscopolamine from homogenates of the rat cerebral cortex. Half-maximal occupation of cortical muscarinic receptors by 6a, 6b, 7a, and 7b was achieved at concentrations of 0.8, 5.4, 0.3, and 3.3 microM, respectively. The competition curves of 6a, 6b, and 7a were adequately described by a two-site binding equation. The ratio of low- and high-affinity dissociation constants agreed with relative efficacy estimated on the ileum. The thiolanium salt 7a was a fairly potent nicotinic agent on the frog rectus abdominis.
Real time low bit-rate video coding algorithm using multi-stage hierarchical vector quantization (2002)

We propose a low bit-rate coding algorithm for wireless communication based on multi-stage hierarchical vector quantization, motion compensation and differential pulse code modulation. Our method adapts bit allocation to spatial and temporal correlation. Conventional schemes based on the discrete cosine transform (DCT) need a large amount of computation on both encoding and decoding. On the other hand, our proposed method consists of addition, subtraction and shift operation. It does not use multiplication. It can decode in real time on a conventional serial processor. Encoding by vector quantization (VQ), however, consumes a large amount of computation. We developed a new LSI to accelerate VQ. Our scheme can send 10 frames of QCIF video sequences through a 29.2 kbps line. The quality of reconstructed image is over 30 dB.
ON SEISMIC COMPUTATIONS, WITH APPLICATIONS, I (1936)

Abstract The problem of depth determinations from data obtained by the method commonly called “reflection shooting” is an interesting one and one which, very often, assumes an importance that justifies a good deal of study. It is the purpose of this paper to indicate a method for depth determination in two cases which very closely approximate some situations. It turns out that the discussion leads to a set of charts which are universal in the sense that the charts are based on dimensionless quantities and are therefore applicable to any set of units and for any “spreads” desired. Inasmuch as “average vertical velocities” are often used in practice, the cases considered in this paper are compared with the results obtained by using the “average vertical velocities,” and it is found that for short “spreads” the depths obtained by either method check very well.
Risk Management Working Group (2002)

INSIGHT is the magazine of the International Council on Systems Engineering. It is published four times per year and features informative articles dedicated to advancing the state of practice in systems engineering and to close the gap with the state of the art. INSIGHT delivers practical information on current hot topics, implementations, and best practices, written in applications-driven style.
Skin test sensitivity and antigen-induced lymphocyte transformation in uraemia. (1973)

Serial tuberculin skin tests with 0·1–100 TU of PPD were performed on 209 patients with chronic renal disease. Skin test reactivity decreased with the severity of uraemia. Lymphocytes from three out of four skin test negative patients showed a high PPD-induced blast response in vitro. Thus, the absence of skin reactivity in uraemia does not always depend on a lack of antigen-sensitive lymphocytes.
Financial aspects of cloud computing business models (2010)

The purpose of the study was to explore financial aspects of cloud computing business mod-els from information technology (IT) services provider’s perspective. The financial aspects were divided into revenue model and related pricing mechanisms and cost structure and re-lated cost accounting mechanisms according to business model ontology. Cloud computing is a new computing paradigm and the latest megatrend in IT industry devel-oped as a result of the convergence of numerous new and existing technologies. It is characterized by provision of rapidly scalable and measurable IT capabilities as a service on on-demand and self-service basis over the network from common resource pool. The study was carried out as a single case study in a global company offering IT services for large enterprises and public organizations and currently preparing to introduce its own cloud services. Ten semi-structured interviews were conducted with managers of the case company for exploring the financial aspects of cloud services. Qualitative data analysis was employed for processing and summarizing the findings. Findings of the study suggested that each cloud service should have a distinct business model. The business model is a mediating construct that translates the new technology to the serv-