gebhart/patrepeval huggingface dataset:
Design and Characterization of the TERO-PUF on SRAM FPGAs (2016)

Physical unclonable functions (PUF) are a promising approach in design for trust and security. A PUF derives a unique identifier for different similar dies using some of their physical characteristics, so it can be used to authenticate chips and to fight against counterfeiting and theft of devices. The transient effect ring oscillator (TERO) PUF is based on the extraction of the entropy of the process variations by comparison between TERO cells characteristics. This TERO cell needs to be carefully designed in order to construct a PUF. This task needs to be done with precision, especially in the size of used gates and in the delays of all connections inside the cell. This is particularly challenging in FPGA. This paper presents the design of TERO cells in two FPGA families: Xilinx Spartan 6 and Altera Cyclone V. Additionally, results of the characterization of the TEROPUF are presented and compared for the two technologies. The reproducibility of experimental results are guaranteed by the online access to all design files.
β‐Carotene cleavage products induce oxidative stress <i>in vitro</i> by impairing mitochondrial respiration (2002)

ABSTRACT Carotenoids are widely used as important micronutrients in food. Furthermore, carotenoid supplementation has been used in the treatment of diseases associated with oxidative stress. However, in some clinical studies harmful effects have been observed, for example, a higher incidence of lung cancer in individuals exposed to extraordinary oxidative stress. The causal mechanisms are still unclear. Carotenoid cleavage products (CCPs), including highly reactive aldehydes and epoxides, are formed during oxidative attacks in the course of antioxidative action. Here, we tested the hypothesis that CCPs may increase oxidative stress by impairing mitochondrial function. We found that CCPs strongly inhibit state 3 respiration of isolated rat liver mitochondria even at concentrations between 0.5 and 20 μM. This was true for retinal, β‐ionone, and mixtures of cleavage products, which were generated in the presence of hypochlorite to mimic their formation in inflammatory regions. The inhibition of mitochondrial respiration was accompanied by a reduction in protein sulfhydryl content, decreasing glutathione levels and redox state, and elevated accumulation of malondialdehyde. Changes in mitochondrial membrane potential favor functional deterioration of the adenine nucleotide translocator. The findings may reflect a basic mechanism of increasing the risk of cancer induced by CCPs.
The weighted proportional fair scheduler (2006)

To this day, traffic in cellular networks is still mainly real-time. However, with the deployment of new technologies, such as HDR (High Date Rate) and HSDPA (High Speed Downlink Packet Access), this situation is bound to evolve rapidly and elastic traffic will significantly increase. These novel technologies implement opportunistic scheduling, taking advantage of the delay-tolerance of elastic traffic, to augment the global capacity of the system. Previous work has shown that "Proportional Fair" (PF) is an opportunistic scheduler that provides a good compromise between fairness and efficiency. Nevertheless, the hypotheses according to which these results are obtained are not always valid in real environments. In this paper, we propose a modified version of PF that not only introduces flexibility in sharing resources between active users but also allows for a fair allocation of resources in realistic environments.
Mesh forging: editing of 3D-meshes using implicitly defined occluders (2003)

In recent years the ease of use and the flexibility in the editing process shifted into focus in modelling and animation applications. In this spirit we present a 3D mesh editing method that is similar to the simple constrained deformation (scodef) method9. We extend this method to the so-called mesh forging paradigm by adding an occluder to the editing environment. Our method resembles and was in fact motivated by the forging process where an anvil is used to give the manipulated object the desired shape. While users perform the editing operation by directly manipulating the 3D-mesh, the occluder is defined implicitly. To enable fine detail edits even in sparsely triangulated areas, we propose an adaptive refinement method that also allows the creation of sharp features where desired. The functionality and ease of use of our editing approach is shown by several examples.
Germanium as a versatile material for low-temperature micromachining (1999)

Though germanium (Ge) shares many similar physical properties with silicon (Si), it also possesses unique characteristics that are complementary to those of Si. The advantages of Ge include its compatibility with Si microfabrication, its excellent gas and liquid phase etch selectivity to other materials commonly used in Si micromachining, and its low deposition temperature (<350/spl deg/C) that potentially allows Ge to be used after the completion of a standard CMOS run. Wider applications of Ge as a structural, sacrificial, and sensor material require a more systematic investigation of its processing and properties. The results of such an undertaking are presently reported. The topics covered are the formation of Ge thin films and novel application of the selective deposition of Ge to etch hole filling, characterization of the effects of thermal treatment on the evolution of the residual stress in Ge thin films, etch selectivity for etch mask and sacrificial layer applications, and gas phase release technique for stiction elimination.
Patterning organic light-emitting diodes by cathode transfer (2002)

A technique is presented for patterning the metal cathode of organic light-emitting diodes that allows for cathode engineering. The technique involves transferring pretreated and prepatterned metal on a substrate onto the surface of organic layers of the device by pressing, utilizing a difference in the adhesion strength of the metal between the substrate and the underlying organic layer. This cathode transfer technique is applied to fabricating a 20×10 passive matrix display with a pixel size of 250 μm by 250 μm.
Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: Incidence of cross‐reactive idiotopes and expression of V<sub>H</sub> and V<sub>ϰ</sub> subgroups (1990)

A panel of 14 human monoclonal and monoreactive IgM rheumatoid factors (RF) derived from the synovial tissue of rheumatoid arthritis (RA) patients was studied for the expression of cross-reactive idiotopes (CRI) and variable heavy (VH) and variable kappa (V kappa) subgroups. Four of the twelve kappa RF expressed light chains of the V kappa III subgroup. Three of these were characterized as belonging to the V kappa IIIb sub-subgroup, and expressed the V kappa IIIb associated CRI, 17.109. None of the RF expressed the V kappa IIIa-associated CRI, 6B6.6. One of the fourteen RF expressed the VH-associated CRI, G6, and five expressed either or both the VHIII-associated CRI, B6 and D12. Seven RF bound to protein A (SpA), which indicates the expression of VHIII subgroup V regions. Together the data indicated that 9/11 RF express VHIII regions and 2/11 express VHI regions. There was no obvious correlation between V region usage or CRI expression and fine specificity of the RF for human IgG subclasses. These data indicate a difference in V gene usage by RF derived from RA patients compared with RF paraproteins derived from non-RA patients. There is not a bias towards variable chains of the V kappa III subgroup, but a marked preference for variable heavy chains of the VHIII subgroup is seen. Further studies may elucidate the pathological significance of these findings in RA.
Word Topic Models for Spoken Document Retrieval and Transcription (2009)

Statistical language modeling (LM), which aims to capture the regularities in human natural language and quantify the acceptability of a given word sequence, has long been an interesting yet challenging research topic in the speech and language processing community. It also has been introduced to information retrieval (IR) problems, and provided an effective and theoretically attractive probabilistic framework for building IR systems. In this article, we propose a word topic model (WTM) to explore the co-occurrence relationship between words, as well as the long-span latent topical information, for language modeling in spoken document retrieval and transcription. The document or the search history as a whole is modeled as a composite WTM model for generating a newly observed word. The underlying characteristics and different kinds of model structures are extensively investigated, while the performance of WTM is thoroughly analyzed and verified by comparison with the well-known probabilistic latent semantic analysis (PLSA) model as well as the other models. The IR experiments are performed on the TDT Chinese collections (TDT-2 and TDT-3), while the large vocabulary continuous speech recognition (LVCSR) experiments are conducted on the Mandarin broadcast news collected in Taiwan. Experimental results seem to indicate that WTM is a promising alternative to the existing models.
Sparc T4: A Dynamically Threaded Server-on-a-Chip (2012)

The Sparc T4 is the next generation of Oracle's multicore, multithreaded 64-bit Sparc server processor. It delivers significant performance improvements over its predecessor, the Sparc T3 processor. The authors describe Sparc T4's key features and detail the microarchitecture of the dynamically threaded S3 processor core, which is implemented on Sparc T4.
Characterization of Vernix Caseosa as a Natural Biofilm: Comparison to Standard Oil‐Based Ointments (2000)

The application of occlusive films and oil-in-oil ointments has been reported to improve epidermal barrier function in very low birthweight, preterm infants. Such infants have a structurally immature stratum corneum and lack a surface coating of vernix caseosa. In this study we examined the short-term effects of topical application of vernix caseosa to human skin and contrasted these effects with commonly used ointments and water-in-oil emulsions. Specifically, vernix, Eucerin(R), Aquaphor(R), and petrolatum were applied to the volar skin surface of adult volunteers. Surface electrical capacitance (SEC) and transepidermal water loss (TEWL) were measured as indices of surface hydration. Sorption-desorption profiles were performed to determine skin surface hydrophobicity. Particular attention was given to monitoring the acute (0-120 minutes) changes following vernix treatment in order to compare these effects with earlier reports on the rate of skin surface drying in newborn infants following birth. Immediately after vernix application there was an increase in the rate of water loss from the skin surface. Relative to control skin and skin treated with the ointments and water-in-oil emulsions, the application of vernix to freshly bathed human skin resulted in a unique profile of temporal change in baseline surface hydration, moisture accumulation, and water-holding capacity. These results demonstrate major differences between human vernix and standard oil-based topical ointments. The results provide a framework for discussing the various properties of topical barriers applied to the very low birthweight infant.
Allylic C−H Amination for the Preparation of <i>syn</i>-1,3-Amino Alcohol Motifs (2009)

A highly selective and general Pd/sulfoxide-catalyzed allylic C-H amination reaction en route to syn-1,3-amino alcohol motifs is reported. Key to achieving this reactivity under mild conditions is the use of electron-deficient N-nosyl carbamate nucleophiles that are thought to promote functionalization by furnishing higher concentrations of anionic species in situ. The reaction is shown to be orthogonal to classical C-C bond-forming/-reduction sequences as well as nitrene-based C-H amination methods.
Integrated Gigant Magnetic Resistance based Angle Sensor (2006)

An integrated GMR (Giant-Magnetic-Resistance) sensor is presented for 360° angular measurements of rotating magnetic fields in automotive applications. The spin-valve GMR-layers are directly applied to a standard semiconductor 0.22μm CMOS process by vertical integration of the sensor-bridges atop of active circuitry. The entire integrated angle-sensor comprises 2 orthogonal magnetized GMR-bridges for sine and cosine signal measurements, and the subsequent signal conditioning circuitry. The entire angular sensor is designed to work in harsh automotive environment in a temperature range of -40°C to 150°C. The strength for best precision covers a wide range from 20 to 50 mT. The resulting angular information itself can be obtained by SPI-readout and calculating the arc-trigonometric function of the bridge signals with a resolution of > 13bit in an auxiliary microcontroller. After individual calibration to compensate for production spread an accuracy of typical 0.5° is achieved.
Three‐dimensional structures of <i>Drosophila melanogaster</i> acetylcholinesterase and of its complexes with two potent inhibitors (2000)

We have crystallized Drosophila melanogaster acetylcholinesterase and solved the structure of the native enzyme and of its complexes with two potent reversible inhibitors, 1,2,3,4-tetrahydro-N-(phenylmethyl)-9-acridinamine and 1,2,3,4-tetrahydro-N-(3-iodophenyl-methyl)-9-acridinamine--all three at 2.7 A resolution. The refined structure of D. melanogaster acetylcholinesterase is similar to that of vertebrate acetylcholinesterases, for example, human, mouse, and fish, in its overall fold, charge distribution, and deep active-site gorge, but some of the surface loops deviate by up to 8 A from their position in the vertebrate structures, and the C-terminal helix is shifted substantially. The active-site gorge of the insect enzyme is significantly narrower than that of Torpedo californica AChE, and its trajectory is shifted several angstroms. The volume of the lower part of the gorge of the insect enzyme is approximately 50% of that of the vertebrate enzyme. Upon binding of either of the two inhibitors, nine aromatic side chains within the active-site gorge change their conformation so as to interact with the inhibitors. Some differences in activity and specificity between the insect and vertebrate enzymes can be explained by comparison of their three-dimensional structures.
Repellency of Naturally Occurring or Related Compounds, DEET, and Para-Menthane-3,8-Diol to Bed Bugs (Hemiptera: Cimicidae) (2018)

Bed bugs, Cimex lectularius L. (Hemiptera: Cimicidae), have become a major health nuisance in the past 20 ysin cities and elsewhere throughout many areas of the world. Few studies have reported on repellent compounds that could reduce their transport in luggage. We evaluated the repellency of six naturally occurring or related compounds used in flavor/fragrance applications or structurally related compounds, para-menthane-3,8-diol, and N,N-diethyl-meta-toluamide (DEET) to bed bugs in a 183 × 183-cm arena . Repellency was assessed using soft-sided polyester lunch bags serving as surrogates of luggage and barrier cloth towels upon which rested untreated lunch bags. We report for the first time repellency of delta dodecalactone, 2-(3, 7-dimethyl-2, 6-nonadien-1-yl)-cyclopentanone (a.k.a. 'methyl apritone'), gamma dodecalactone, and para-menthane-3,8-diol to bed bugs. Propyl dihydrojasmonate, 3-methyl-5-hexyl-2-cyclohexenone, gamma methyl tridecalactone, and DEET are also documented to be repellent to bed bugs. These compounds provided relatively long-term protection. Propyl dihydrojasmonate prevented bed bugs from seeking refuge in treated lunch bags 27 d after treatment, and when applied to cloth towels repelled harborage-seeking bed bugs for 146 d. Methyl apritone blended with 3-methyl-5-hexyl-2-cyclohexenone and delta dodecalactone as an individual compound applied to cloth towels repelled bed bugs for 190 and 276 d, respectively. The above-mentioned compounds, either individually or as blends, may reduce risk of bed bugs seeking harborage in treated suitcases or towels upon which untreated luggage is placed.
A ZVS resonant receiver with maximum efficiency tracking for device-to-device wireless charging (2016)

A receiver for efficient wireless power delivery at 6.78MHz from smartphones to IoT devices has been designed in 0.18 μm CMOS. The receiver implements a technique to estimate the end-to-end efficiency and achieve maximum efficiency-point tracking (MEPT) across the charge cycle of a Li-ion battery without needing an explicit communication channel with the transmitter. The MEPT technique is tested using two rectifier topologies designed in the same process - the commonly used synchronous full-bridge and a resonant topology with ZVS for high efficiency. Adding MEPT to the full bridge receiver yields an estimated 7.9% savings in transmitter energy in fully charging a Li-ion battery on the receiver, while using the resonant rectifier with MEPT achieves 13.8% total savings in transmitter energy.
Suzuki Coupling at the 2-Position of Densely Functionalized Pyrimidones (2006)

A variety of ethyl 1-substituted 2-aryl-5-ethoxy-6-oxo-1,6-dihydropyrimidine-4-carboxylates were synthesized by efficient thermal or microwave-promoted Suzuki coupling of 2-chloro-N1-substituted precursors.
System studies of coal fired-closed cycle MHD for central station power plants (1976)

This paper presents a discussion of the closed-cycle MHD results obtained in a recent study of various advanced energy-conversion power systems. The direct coal-fired MHD topping-steam bottoming cycle was established as the current choice for central station power generation. Emphasis is placed on the background assumptions and the conclusions that can be drawn from the closed-cycle MHD analysis. It is concluded that closed-cycle MHD has efficiencies comparable to that of open-cycle MHD. Its cost will possibly be slightly higher than that of the open-cycle MHD system. Also, with reasonable fuel escalation assumptions, both systems can produce lower-cost electricity than conventional steam power plants. Suggestions for further work in closed-cycle MHD components and systems are made.
Intranasal Vaccination with Proinsulin DNA Induces Regulatory CD4+ T Cells That Prevent Experimental Autoimmune Diabetes (2006)

Insulin, an autoantigen in type 1 diabetes, when administered mucosally to diabetes-prone NOD mice induces regulatory T cells (T(reg)) that protect against diabetes. Compared with protein, Ag encoded as DNA has potential advantages as a therapeutic agent. We found that intranasal vaccination of NOD mice with plasmid DNA encoding mouse proinsulin II-induced CD4+ T(reg) that suppressed diabetes development, both after adoptive cotransfer with "diabetogenic" spleen cells and after transfer into NOD mice given cyclophosphamide to accelerate diabetes onset. In contrast to prototypic CD4+ CD25+ T(reg), CD4+ T(reg) induced by proinsulin DNA were both CD25+ and CD25- and not defined by markers such as glucocorticoid-induced TNFR-related protein (GITR), CD103, or Foxp3. Intriguingly, despite induction of T(reg) and reduced islet inflammation, diabetes incidence in proinsulin DNA-treated mice was unchanged. However, diabetes was prevented when DNA vaccination was performed under the cover of CD40 ligand blockade, known to prevent priming of CTL by mucosal Ag. Thus, intranasal vaccination with proinsulin DNA has therapeutic potential to prevent diabetes, as demonstrated by induction of protective T(reg), but further modifications are required to improve its efficacy, which could be compromised by concomitant induction of pathogenic immunity.
Intra-LIS IP multicast among routers over ATM using Sparse Mode PIM (1998)

This document describes how intra-LIS IP multicast can be efficiently supported among routers over ATM without using the Multicast Address Resolution Server (MARS). The method described here is specific to Sparse Mode PIM [PIM-SM], and relies on the explicit join mechanism inherent in PIM-SM to notify routers when they should create group specific point-to-multipoint VCs.
PENICILLIN IN THE TREATMENT OF CUTANEOUS DISEASE (1945)

Not since therapy with the sulfonamide compounds was introduced has there been any therapeutic agent as completely studied as penicillin. The startling and almost miraculous results obtained by the use of this agent in the treatment of gonorrhea, meningitis, syphilis and septicemia are well known. It is our purpose to review the results obtained in the treatment of some cutaneous diseases with penicillin locally and parenterally administered. The penicillin obtained was the dry, amorphous, yellowish form, and its sodium salt was the preparation used clinically. The solution employed contained 400 to 600 Oxford units per cubic centimeter. This was applied to the affected areas as a wet dressing, so that the lesions were constantly dampened with the penicillin solution. To prevent the solution from evaporating rapidly, the saturated gauze was well covered with oilcloth. For the intramuscular injections, 20,000 units of penicillin was mixed
ChemInform Abstract: Structure‐Activity Relationships of a New Family of Steroidal Aromatase Inhibitors. Part 1. Synthesis and Evaluation of a Series of Analogues Related to 19‐((Methylthio)methyl)androstenedione (RU54115). (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hepatic OATP1B Transporters and Nuclear Receptors PXR and CAR: Interplay, Regulation of Drug Disposition Genes, and Single Nucleotide Polymorphisms (2009)

Drug uptake transporters are now increasingly recognized as clinically relevant determinants of variable drug responsiveness and unexpected drug-drug interactions. Emerging evidence strongly suggests members of the organic anion transporting polypeptide (OATP) family appear to be particularly important to the disposition of many drugs in clinical use today. Specifically, the liver-enriched OATP1B subfamily members OATP1B1 and OATP1B3 exhibit broad substrate specificity and the ability to transport drugs which are ligands for xenobiotic sensing nuclear receptors such as the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR). Accordingly, OATP1B transporters may indirectly regulate expression of drug metabolism genes via modulation of the intracellular concentration of PXR and CAR ligands. Moreover, a number of functionally important single nucleotide polymorphisms (SNPs) in OATP1B transporters have been described. In this review, a brief summary of known SNPs in PXR and CAR will be followed by an in-depth outline of OATP1B1 and OATP1B3 transporters particularly in relation to the known SNPs in these OATPs and the interplay between OATP1B transporters with PXR and CAR, both in vitro and in vivo.
[Development of lens opacities in a period of 6 months after pneumatic retinopexy]. (1991)

When performing a pneumatic retinopexy, air or gas is injected into the vitreous cavity to reattach a primary, rhegmatogenous retinal detachment. SF6 gas, for examples, remains in the vitreous cavity for up to 2 weeks before it is completely absorbed. It is conceivable that the injection of SF6 gas into the vitreous cavity interferes with lens metabolism, thus causing opacities of the lens. Even minor early changes in lens transparency can be monitored by Scheimpflug photography. Two months after performing a pneumatic retinopexy, 31 out of 100 consecutive eyes showed a loss of lens transparency, which was not pronounced or statistically significant. Six months after surgery the loss of transparency was more pronounced in all lens layers, increasing from the front to the back. The increment was statistically significant for the anterior lens cortex. Further investigations are needed to determine whether lens changes are the result of the intraocular tamponade with SF6 gas or are related to other factors, such as the surgical maneuver itself.