gebhart/patrepeval huggingface dataset:
Measurement of Naval Ship Responses to Underwater Explosion Shock Loadings (2003)

The shock‐resistance capability of battle ships against a non‐contact underwater explosion (UNDEX) is a very critical factor of survivability. In July 1987 and April 2000, we successfully conducted UNDEX shock tests for a coastal mine hunter (MHC) and a mine sweeper/hunter (MSH) of Republic of Korea Navy (ROKN), at the Chinhae bay, Korea. Test planning for conducting these shock tests included responsibilities, methods, and procedures. Test instruments were developed and tested on a drop shock machine to confirm availability in the actual shock tests with emphasis on shock resistance, remote control and reliability. All vital systems of the ships were confirmed to be capable of normal operational condition without significant damages during the explosion shot. By analyzing the test results, the tactical operational safety zone of the ships in underwater explosion environments was estimated. In this paper, we described the results of measurement of naval ship responses to underwater explosion shock loadings including test planning, sensor locations, data reduction, explosive devices, instrumentation and damage assessments of MSH.
Studies of Acute Effects of Insulin-Like Growth Factors I and II in Human Fat Cells* (1987)

The acute metabolic effects and receptor binding of insulin-like growth factors (IGFs) I and II were studied in human adipose tissue. The IGFs inhibited fat cell glycerol release and stimulated adipocyte 3-O-methylglucose transport and adipose tissue glucose oxidation as effectively as did insulin, but the biological potencies of the IGFs, on a molar basis, were 600-1000 times less than that of insulin. The insulin dose-response curve for antilipolysis gradually shifted to the left in the presence of submaximally and maximally effective IGF-I concentrations, whereas no additive response was found when fat cells were incubated with maximally effective concentrations of insulin and the IGFs. Adipocyte [125I]IGF-I and -II binding was low and was not inhibited by excess unlabeled IGF. In contrast, IGF-I inhibited [125I]insulin binding with a molar potency 1600 times lower than that of native insulin. In adipose tissue segments obtained from patients with untreated noninsulin-dependent diabetes mellitus, IGF-I and insulin inhibited glycerol release in a normal way. Conversely, neither insulin nor IGF-I increased the rate of glucose oxidation significantly above the nonhormone-stimulated level. We conclude that human fat cells lack specific cell surface IGF-binding sites. However, the IGFs definitely produce acute insulin-like effects in the human adipocyte, which seems to be mediated via the insulin receptor.
Recent Advances in Applications of Droplet Microfluidics (2015)

Droplet-based microfluidics is a colloidal and interfacial system that has rapidly progressed in the past decade because of the advantages of low fabrication costs, small sample volumes, reduced analysis durations, high-throughput analysis with exceptional sensitivity, enhanced operational flexibility, and facile automation. This technology has emerged as a new tool for many recently used applications in molecular detection, imaging, drug delivery, diagnostics, cell biology and other fields. Herein, we review recent applications of droplet microfluidics proposed since 2013.
A multi‐purpose dynamic and tactile sensor for robot manipulators (1987)

Abstract In this article, a multi‐purpose tactile/acceleration sensor system made of newly developed thick polymeric piezoelectric material and capable of sensing acceleration, contact force and pressure is developed and evaluated using analytical and experimental techniques, The sensor system is discretized and modeled by a single degree of freedom second order system from which equations of electromechanical dynamics are formulated to evaluate its performance. Analytical solutions are compared favorably with experimental results.
An overview on in situ micronization technique – An emerging novel concept in advanced drug delivery (2013)

The use of drug powders containing micronized drug particles has been increasing in several pharmaceutical dosage forms to overcome the dissolution and bioavailability problems. Most of the newly developed drugs are poorly water soluble which limits dissolution rate and bioavailability. The dissolution rate can be enhanced by micronization of the drug particles. The properties of the micronized drug substance such as particle size, size distribution, shape, surface properties, and agglomeration behaviour and powder flow are affected by the type of micronization technique used. Mechanical communition, spray drying and supercritical fluid (SCF) technology are the most commonly employed techniques for production of micronized drug particles but the characteristics of the resulting drug product cannot be controlled using these techniques. Hence, a newer technique called in situ micronization is developed in order to overcome the limitations associated with the other techniques. This review summarizes the existing knowledge on in situ micronization techniques. The properties of the resulting drug substance obtained by in situ micronization were also compared.
Free mobility determination by electrophoresis in polyacrylamide containing agarose at a nonrestrictive concentration (1991)

In the determination of the free mobility, related to the surface net charge, by quantitative gel electrophoresis, the previous arbitrary extrapolation of Ferguson plots from the lowest gel concentrations that give a mechanically stable gel to 0% T has recently been replaced by measurement of mobilities across that concentration range, using the addition of 0.5% agarose to polyacrylamide at the various low concentrations in application to a DNA fragment 155 bp in size (Orbán, L. et al., in preparation). The present study applies that approach to several proteins and DNA fragments smaller than 1300 bp, using 0.4% agarose in polyacrylamide gels of varying concentration. The intercepts of the plots with the mobility axis provide experimental data by which the free mobility in polyacrylamide gel electrophoresis can be estimated for molecules not significantly retarded in their migration at the agarose concentration admixed to polyacrylamide. Across the gel concentration range below 3% T, in the presence of agarose, the Ferguson plots of proteins and DNA fragments are convex. It was shown by mass spectrometry that this convex curvature of the plots in the mixed polymer is not significantly due to low polymerization efficiency in the concentration range of liquid polyacrylamide (below 3%T).
Potential of Stress-inducing Wedge-shaped Defect of Tooth (1996)

The wedge-shaped defect (WSD) is frequently observed in the cervical region of tooth, especially on the buccal surface. It has been long demonstrated that WSD might be attributed to the incorrect or excessive toothbrushing. Recently, however, a new concept of WSD induced by occlusal forces has been proposed. The present study examined the stress bearing in the premolar cervical region for applied occlusal forces using a strain gauge in vitro and also observed the existence of WSD and facets in 304 extracted maxillary premolars in order to estimate the possibility of such a cause of WSD. The WSD was found in 198 teeth out of 304 (65.1%), in which 185 teeth (93.4%) had the defect in their buccal cervical region. Regardless of the presence of WSD, one or multiple occlusal facets were detected in most of the teeth. Only 15 teeth exhibited no facet. There was also no WSD in them. Among the teeth having WSD, the frequency of those which were accompanied by the facets at the buccal or lingual triangular ridge and/or the tip of lingual cusp was predominant, indicating a possibility that they might have occurred by a common action of occlusal force. From the strain measurement, on the other hand, it was found that the buccal cervical region was subjected to a considerable tensile or compressive stress when a load was separately applied on the areas showing facets mentioned above. These findings suggest that the occlusal force may cause complicated stresses to be a potential factor inducing WSD in the buccal cervical region.
The Effect of Purified Extract of<i>Fagopyrum esculentum</i>(Buckwheat) on Protein Kinases Involved in Signal Transduction Pathways (1996)

The effect of a purified extract of the flowering herb of Fagopyrum esculentum (buckwheat) on various protein kinases involved in signal transduction was examined. We observed that buckwheat contains red fluorescent compounds having photosensitizing properties. Spectrophotometric analysis of the extract has indicated structural similarity to hypericin. Dose- and light-dependent inhibition of various protein kinases was observed. The purified buckwheat extract strongly inhibited two receptor-associated protein tyrosine kinases (EGF-R and Ins-R) and a Ser/Thr kinase (PK-C) at an ng/ml concentration range. Selectivity was exhibited as a decreased sensitivity to cytosolic PTKs and protein kinase CK-2. The protein kinases are important components of the signal transduction pathway. Aberration of signal transduction is a hallmark of several proliferative diseases. Our results indicate that photosensitizing compounds in buckwheat are potential antiproliferative agents.
Volume Conductivity and Scatter Parameters as an Indicator of Acute Bacterial Infections by the Automated Haematology Analyser (2016)

The Volume, Conductivity & Scatter parameters like Mean Neutrophil Volume & Mean Monocyte Volume are more sensitive parameters and could prove to be a quick diagnostic indicator of acute bacterial infections.
Isolation and characterization of the constitutive acyl carrier protein from Rhizobium meliloti (1990)

Rhizobium species produce an inducible acyl carrier protein (ACP), encoded by the nodF gene, that somehow functions in an exchange of cell signals between bacteria and specific plant hosts, leading to nodulation of plant roots and symbiotic nitrogen fixation, as well as a constitutive ACP needed for the synthesis of essential cell lipids. The periplasmic cyclic glucans of Rhizobium spp. are also involved in specific rhizobium-plant interaction. These glucans are strongly similar to the periplasmic membrane-derived oligosaccharides (MDO) of Escherichia coli. E. coli ACP is an essential component of a membrane-bound transglucosylase needed for the biosynthesis of MDO, raising the possibility that either or both of the rhizobial ACPs might have a similar function. We have now isolated the constitutive ACP of R. meliloti and determined its primary structure. We have also examined its function, together with those of ACPs from E. coli, Rhodobacter sphaeroides, and spinach, in the MDO transglucosylase system and as substrate for the E. coli ACP acylase enzyme. All four ACPs act as acceptors of acyl residues, but only the E. coli ACP functions in the transglucosylase system.
Preclinical Mouse Models of Human Prostate Cancer and Their Utility in Drug Discovery (2010)

In vivo animal experiments are essential to current prostate cancer research, and are particularly critical to studying interactions between tumor cells and their microenvironment. Numerous pre-clinical animal models of prostate cancer are currently available, including transgenic mouse models and human prostate cancer xenograft mouse models. In contrast to transgenic mouse models producing more heterogeneous cohorts of tumors, xenograft mouse models provide more controlled approaches. This unit describes the detailed procedures necessary to establish several distinct pre-clinical mouse models of human prostate cancer, including an orthotopic prostate xenograft model, an orthotopic bone metastasis model, an experimental metastasis model of intra-cardiac injection, and a vossicle model of tumor-bone interaction.
Pothole tagging system (2011)

4th Robotics and Mechatronics Conference of South Africa (RobMech 2011), CSIR International Conference Centre, Pretoria, 23-25 November 2011
Survey of a medically indigent population in south Dallas, Texas, 1969 (1972)

Thompson, Loweby; Luby, J. P.; Babnett, J. A.; Dewiett, H. J.; Vandebsloot, Jan; Reavis, L. D.; Reagan, S. G. Author Information
Sensitive Detection of Transitional Spectral Pattern Using Optical Spectrogram Scope (2003)

We propose a new method using analysis before acquisition (here, we call it the preprocessing method) to inhibit the influence of the properties of the detector in pulse measurement. We introduce concepts of optical signal processing into the pulse measurement system to realize the preprocessing method. Optical spectrogram scope (OSS) proposed by us is a pulse measurement system based on an optical correlation technique using an optical filtering technique, which enables the introduction of various processing methods into the OSS system by designing the optical filter. In this paper, we propose the preprocessing method using OSS, and demonstrate the sensitive detection of a transitional spectral pattern as an example of the pulse measurement using the preprocessing method.
Physikalische und biologische Wirkungen von in Luft gebildeten “Kleinionen” (1962)

Article Physikalische und biologische Wirkungen von in Luft gebildeten “Kleinionen” was published on January 1, 1962 in the journal Biomedical Engineering / Biomedizinische Technik (volume 7, issue 4).
Functional and structural mapping of human cerebral cortex: Solutions are in the surfaces (1998)

The human cerebral cortex is notorious for the depth and irregularity of its convolutions and for its variability from one individual to the next. These complexities of cortical geography have been a chronic impediment to studies of functional specialization in the cortex. In this report, we discuss ways to compensate for the convolutions by using a combination of strategies whose common denominator involves explicit reconstructions of the cortical surface. Surface-based visualization involves reconstructing cortical surfaces and displaying them, along with associated experimental data, in various complementary formats (including three-dimensional native configurations, two-dimensional slices, extensively smoothed surfaces, ellipsoidal representations, and cortical flat maps). Generating these representations for the cortex of the Visible Man leads to a surface-based atlas that has important advantages over conventional stereotaxic atlases as a substrate for displaying and analyzing large amounts of experimental data. We illustrate this by showing the relationship between functionally specialized regions and topographically organized areas in human visual cortex. Surface-based warping allows data to be mapped from individual hemispheres to a surface-based atlas while respecting surface topology, improving registration of identifiable landmarks, and minimizing unwanted distortions. Surface-based warping also can aid in comparisons between species, which we illustrate by warping a macaque flat map to match the shape of a human flat map. Collectively, these approaches will allow more refined analyses of commonalities as well as individual differences in the functional organization of primate cerebral cortex.
Prospects for Anti-Biofilm Pharmaceuticals (2015)

This commentary highlights several avenues currently being pursued in research labs to the development of new anti-biofilm pharmaceuticals. There is a real need for alternative therapeutic modalities for treating the persistent infections that sometimes form on implanted medical devices or compromised niches within the body. Strategies being researched include discovering new antimicrobial agents that kill microorganisms in biofilms more effectively than do existing antibiotics, designing drugs that block microbial adhesion or interfere with intercellular communication, developing chemistries to disperse biofilms, and combining agents with different mechanisms of action. Though the need is great, the pathway to commercialization of new drugs is steep. One possible streamlined approach to navigating the regulatory approval process is to repurpose old drugs, a strategy that a few groups have shown can yield agents with anti-biofilm properties.
Interconnection of CSMA/CD LANs via an N-port bridge (1989)

The interconnection of CSMA/CD LANs using an N-port bridge is considered. The stability and throughput-delay performance of the interconnected system is analyzed approximately by decomposing it into N consistent but otherwise independent LAN subsystems. The performance of a LAN subsystem with bridge priority is evaluated, and the results are used for the performance evaluation of the interconnected system. Simulation results indicate that the decomposition approach provides reasonably accurate performance prediction. The bridge interconnection system is compared to a system in which the bridge is replaced by a repeater, and the performance advantages of the former system over the latter are quantified.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Characterization of the Interaction between the N-Terminal Extension of Human Cardiac Troponin I and Troponin C (2004)

The N-terminal extension of cardiac troponin I (TnI) is bisphosphorylated by protein kinase A in response to beta-adrenergic stimulation. How this signal is transmitted between TnI and troponin C (TnC), resulting in accelerated Ca(2+) release, remains unclear. We recently proposed that the unphosphorylated extension interacts with the N-terminal domain of TnC stabilizing Ca(2+) binding and that phosphorylation prevents this interaction. We now use (1)H NMR to study the interactions between several N-terminal fragments of TnI, residues 1-18 (I1-18), residues 1-29 (I1-29), and residues 1-64 (I1-64), and TnC. The shorter fragments provide unambiguous information on the N-terminal regions of TnI that interact with TnC: I1-18 does not bind to TnC whereas the C-terminal region of unphosphorylated I1-29 does bind. Bisphosphorylation greatly weakens this interaction. I1-64 contains the phosphorylatable N-terminal extension and a region that anchors I1-64 to the C-terminal domain of TnC. I1-64 binding to TnC influences NMR signals arising from both domains of TnC, providing evidence that the N-terminal extension of TnI interacts with the N-terminal domain of TnC. TnC binding to I1-64 broadens NMR signals from the side chains of residues immediately C-terminal to the phosphorylation sites. Binding of TnC to bisphosphorylated I1-64 does not broaden these NMR signals to the same extent. Circular dichroism spectra of I1-64 indicate that bisphosphorylation does not produce major secondary structure changes in I1-64. We conclude that bisphosphorylation of cardiac TnI elicits its effects by weakening the interaction between the region of TnI immediately C-terminal to the phosphorylation sites and TnC either directly, due to electrostatic repulsion, or via localized conformational changes.
The Relationship of Gelatinous Fibers to Wood Structure in Eastern Cottonwood (Populus deltoides) (1965)

Wood samples from Populus deltoides Marsh. were used to investigate the relationship of gelatinous fibers to the size and number of other wood elements. An increase in the amount of gelatinous fibers was related to a decrease in diameter and an increase in wall thickness of non-gelatinous fibers. The relative sizes of rays, vessels, and fibers were inter-related, but all of these wood elements decreased in size with an increase in the amount of gelatinous fibers. Apparently environmental conditions controlling the differentiation of gelatinous fibers also influence the development of associated wood elements. Thus, the adverse physical properties of reaction wood must be attributed to all of these structural differences in the wood and not merely to the presence of large numbers of gelatinous fibers.
The Innocent Spouse Problem: Joint and Several Liability for Income Taxes Should Be Repealed. (1990)

Husbands and wives who elect to file joint federal income tax returns are jointly and severally liable for the entire tax due. Ninety-nine percent of married couples who file income tax returns make the election to file jointly, and each spouse thereby incurs personal liability for the other spouse's income taxes. This Article argues that the rule is unfair and unjustified and should be repealed
Synthesis and UV−Visible-Light Photoactivity of Noble-Metal−SrTiO<sub>3</sub> Composites (2006)

The photocatalytic activity of strontium titanate (SrTiO3) perovskite films has been examined and compared with that of commercially available titania (TiO2, Degussa P25) in the degradation of a model pollutant, Victoria Blue dye. The effects of pH, synthesis temperature, and Sr/Ti ratio in the synthesis of the perovskite were examined. SrTiO3 was prepared using Ag, Pt, or Au and characterized using optical and surface analysis methods. We found no clear evidence of substitution of the noble metal into the SrTiO3 lattice, and most metal existed as zerovalent metal deposits. Addition of Ag to SrTiO3 showed the most promising catalytic activity toward dye degradation. Degradation of the dye under UV−visible light was also observed to be enhanced only for Ag−SrTiO3.
Guide to Receptors and Channels (GRAC), 3rd edition (2008)

The article offers information on the "Guide to Receptors and Channels (GRAC)" distributed with this journal. GRAC aims to produce an authoritative but user-friendly publication, which allows a gradual overview of the major properties of a wide range of potential pharmacological targets. The Guide comprises pharmacological targets of similar structure/function.
NEURAL STEM CELLS (NSCs): THE STATE OF THE ART & FUTURE DIRECTIONS. (2000)

Third International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance: Maui, Hawaii; November 15-18, 2000: Abstracts
Subaru Adaptive Optics Program (1996)

SUBARU telescope is being constructed atop Mauna Kea in the Hawaii island. It employs an 8.2 m thin-meniscus primary mirror that is supported by 261 actuators and 3 fixed points and will provide an almost perfect surface figure for the near infrared imaging. Under such circumstances, the atmospheric turbulence will become the dominant source of image degradation. Therefore, an adaptive optics (hereafter AO) system is essential in attaining the high resolution imaging capability for large ground-based telescopes.
A New Method for Designing Causal Stable IIR Variable Fractional Delay Digital Filters (2007)

This paper studies the design of causal stable Farrow-based infinite-impulse response (IIR) variable fractional delay digital filters (VFDDFs), whose subfilters have a common denominator. This structure has the advantages of reduced implementation complexity and avoiding undesirable transient response when tuning the spectral parameter in the Farrow structure. The design of such IIR VFDDFs is based on a new model reduction technique which is able to incorporate prescribed flatness and peak error constraints to the IIR VFDDF under the second order cone programming framework. Design example is given to demonstrate the effectiveness of the proposed approach.
Association of an HLA-DQ Allele With Clinical Tuberculosis (1998)

The HLA-DQB1*0503 allele is significantly associated with susceptibility to TB in Cambodian patients and, to our knowledge, is the first identified gene associated with development of clinical TB.