gebhart/patrepeval huggingface dataset:
Saponins and Other Constituents from the Leaves of Aralia elata (2005)

A new triterpenoid saponin, together with five known saponins, were isolated from the nonpolar n-hexane fraction of the leaves of Aralia elata. The structure of the new saponin, durupcoside C, was elucidated as hederagenin 3-O-beta-D-glucopyranosyl(1-->3)-beta-D-glucopyranosyl(1-->3)-alpha-L-arabinopyranoside on the basis of spectroscopic analysis. The known saponins were characterized as 3-O-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-arabinopyranosyl hederagenin 28-O-beta-D-xylopyranosyl(1-->6)-beta-D-glucopyranosyl ester, hederagenin 3-O-beta-D-glucopyranosyl(1-->3)-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-arabinopyranoside, oleanolic acid 3-O-beta-D-glucopyranosyl(1-->3)-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-arabinopyranoside, hederagenin 3-O-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-arabinopyranoside (alpha-hederin), and hederagenin 3-O-beta-D-glucopyranosyl(1-->3)-alpha-L-arabinopyranoside (collinsonidin). In addition, two known lipids, Arisaema glyceride 3 and ceramide mixtures were also isolated and characterized. Collinsonidin and two known lipids were isolated for the first time from this plant.
Unsupervised Clickstream Clustering for User Behavior Analysis (2016)

Online services are increasingly dependent on user participation. Whether it's online social networks or crowdsourcing services, understanding user behavior is important yet challenging. In this paper, we build an unsupervised system to capture dominating user behaviors from clickstream data (traces of users' click events), and visualize the detected behaviors in an intuitive manner. Our system identifies "clusters" of similar users by partitioning a similarity graph (nodes are users; edges are weighted by clickstream similarity). The partitioning process leverages iterative feature pruning to capture the natural hierarchy within user clusters and produce intuitive features for visualizing and understanding captured user behaviors. For evaluation, we present case studies on two large-scale clickstream traces (142 million events) from real social networks. Our system effectively identifies previously unknown behaviors, e.g., dormant users, hostile chatters. Also, our user study shows people can easily interpret identified behaviors using our visualization tool.
Coal desulfurization using microwave energy. Final report, August 1976--October 1977 (1978)

The report describes the use of microwave energy and NaOH to remove pyritic and organic sulfur from several U.S. coals. Exposure times on the order of 1 minute at 1 atmosphere of inert gas can remove up to 85% of the sulfur with little or no loss in heating value of the coal. Data analysis suggests that sulfur is converted to water soluble sulfides (Na2S, Na2Sx) in the process and that sulfur conversion follows first-order reaction kinetics. The mechanism by which fast rates of desulfurization are accomplished is most probably related to the fast (and to some degree selective) in-depth heating of the bed. The activation of water, FeS2, and NaOH creates local volatilization, high temperature and pressure conditions which accelerate sulfur reactions before the coal has a chance to decompose. It is also quite possible that local non-equilibrium chemistry (as a result of localized discharge sites) plays a beneficial role.
Preparation and study of some 1-norbornenyl and norbornenyl-1-carbinyl derivatives (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and study of some 1-norbornenyl and norbornenyl-1-carbinyl derivativesJames W. Wilt, Charles T. Parsons, Charles A. Schneider, David G. Schultenover, and William John WagnerCite this: J. Org. Chem. 1968, 33, 2, 694–708Publication Date (Print):February 1, 1968Publication History Published online1 May 2002Published inissue 1 February 1968https://pubs.acs.org/doi/10.1021/jo01266a047https://doi.org/10.1021/jo01266a047research-articleACS PublicationsRequest reuse permissionsArticle Views423Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Mammalian Zona Pellucida: A Matrix That Mediates Both Gamete Binding and Immune Recognition? (2010)

The crucial cell adhesion events required for mammalian fertilization commence when spermatozoa bind to the specialized extracellular matrix of the oocyte, known as the zona pellucida (ZP). Bound gametes then undergo a signal transduction cascade known as acrosomal exocytosis that enables them to penetrate this matrix and fuse with the oocyte to create a new individual. The ZP is therefore the target of intense investigation in the mouse, pig, bovine, and human models. Major goals in such studies are to define the adhesion molecules, signal transduction pathways, and the molecular basis for the species-restricted binding of gametes. Evidence exists indicating that protein-carbohydrate and to a lesser extent protein-protein interactions play a role in the initial gamete binding. More recent findings in an unusual sperm-somatic cell adhesion system indicate that tri- and tetraantennary N-glycans mediate initial sperm-oocyte binding in both the murine and porcine models, but conflicting data exist. A novel paradigm designated the "domain specific model" will be presented that could explain these inconsistencies. Another potential functional role of the ZP is immune recognition. Both spermatozoa and oocytes lack major histocompatibility (MHC) class I molecules that mediate the recognition of self in the immune system. This absence makes gametes less susceptible to class I restricted cytotoxic T lymphocytes, but more vulnerable to natural killer (NK) cells. Therefore a "fail safe" system for NK cell recognition should exist on both types of gametes. Another issue is that oocytes could begin to express paternal major histocompatibility antigens during the blastocyst stage prior to hatching, and thus mechanisms could also be in place to block the development of maternal adaptive immune responses. An enhanced understanding of these issues could facilitate the development of superior infertility treatments and contraceptive strategies, and define central operating principles of immune recognition in the female reproductive system.
Hyper threading-aware Virtual Machine migration (2014)

The policy and sensitivity of VM(Virtual Machine) migration among the clusters or servers has been the center of the debate. If the sensitivity is high, the entire infrastructure's performance is exacerbated due to frequent migration. On the other hand, if the sensitivity is low, the VM's performance on the server can be decreased due to the performance degradation of specific servers or clusters. Also, the policies have a huge impact on VM self or overall infrastructure when VMs are migrated. Therefore, a decision of the policy and sensitivity to balance the loads among clusters or servers is important for retaining the entire infrastructure's performance. In this paper, we introduce the hyper threading-aware migration method in Xen environment, improves the performance of VMs by evaluating if VM's workload is single thread or not, and arranging VMs on proper clusters (with Hyper Thread/without Hyper Thread).
Evaluation of an Outer Loop Retrofit Architecture for Intelligent Turbofan Engine Thrust Control (2006)

The thrust control capability of a retrofit architecture for intelligent turbofan engine control and diagnostics is evaluated. The focus of the study is on the portion of the hierarchical architecture that performs thrust estimation and outer loop thrust control. The inner loop controls fan speed so the outer loop automatically adjusts the engine's fan speed command to maintain thrust at the desired level, based on pilot input, even as the engine deteriorates with use. The thrust estimation accuracy is assessed under nominal and deteriorated conditions at multiple operating points, and the closed loop thrust control performance is studied, all in a complex real-time nonlinear turbofan engine simulation test bed. The estimation capability, thrust response, and robustness to uncertainty in the form of engine degradation are evaluated.
The Human MitoChip: A High-Throughput Sequencing Microarray for Mitochondrial Mutation Detection (2004)

Somatic mitochondrial mutations are common in human cancers, and can be used as a tool for early detection of cancer. We have developed a mitochondrial Custom Reseq microarray as an array-based sequencing platform for rapid and high-throughput analysis of mitochondrial DNA. The MitoChip contains oligonucleotide probes synthesized using standard photolithography and solid-phase synthesis, and is able to sequence >29 kb of double-stranded DNA in a single assay. Both strands of the entire human mitochondrial coding sequence (15,451 bp) are arrayed on the MitoChip; both strands of an additional 12,935 bp (84% of coding DNA) are arrayed in duplicate. We used 300 ng of genomic DNA to amplify the mitochondrial coding sequence in three overlapping long PCR fragments. We then sequenced >2 million base pairs of mitochondrial DNA, and successfully assigned base calls at 96.0% of nucleotide positions. Replicate experiments demonstrated >99.99% reproducibility. In matched fluid samples (urine and pancreatic juice, respectively) obtained from five patients with bladder cancer and four with pancreatic cancer, the MitoChip detected at least one cancer-associated mitochondrial mutation in six (66%) of nine samples. The MitoChip is a high-throughput sequencing tool for the reliable identification of mitochondrial DNA mutations from primary tumors in clinical samples.
John D. Gerhart (1943 – 2003) (2003)

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Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution (1993)

CD11b is a member of the beta 2 subfamily of the human leukocyte integrins. Its expression is limited to mature myeloid and NK cells and is up-regulated during the course of granulocytic and monocytic differentiation. The CD11b/CD18 (Mo1) heterodimer promotes adhesion of granulocytes and monocytes to C3bi-coated bacteria and endothelial cells. In an attempt to relate the exon structure to the known functional domains, as well as to identify and study cis-acting elements that are involved in its tissue-specific expression, we have isolated genomic clones encoding CD11b, deduced the exon/intron organization, and determined the transcriptional start site. The CD11b gene spans 55 kb and is encoded by 30 exons. Its structure closely resembles that of CD11c, another of the three leukocyte integrin alpha-chains, and suggests that these two genes arose by a gene duplication event. Furthermore, comparison of the CD11b gene structure with that of platelet glycoprotein IIb and Drosophila PS2 suggest how the human leukocyte integrins evolved and dispersed during the course of evolution.
Lipids of oleaginous yeasts. Part I: Biochemistry of single cell oil production (2011)

Abstract In the first part of this review, the biochemistry of lipid accumulation in the oleaginous microorganisms is depicted. Lipid biosynthesis form sugars and related substrates is a secondary anabolic activity, conducted after essential nutrient (usually nitrogen) depletion in the medium. Due to this exhaustion, the carbon flow is directed towards the accumulation of intracellular citric acid that is used as acetyl‐CoA donor in the cytoplasm. Acetyl‐CoA generates cellular fatty acids and subsequently triacylglycerols. Lipid accumulation from hydrophobic substrates is a growth associated process, being independent from nitrogen exhaustion in the medium. Medium fatty acids are incorporated with various incorporation rates and are either dissimilated for growth needs or become “substrate” for intracellular biotransformations. “New” fatty acid profiles (in both extra‐ and intracellular lipids) that did not previously exist in the medium are likely to be produced. Oleaginous microorganisms consume their own storage lipids when their metabolic abilities cannot be saturated by the extracellular carbon source. Reserve lipid breakdown is independent from the type of the carbon source used for lipid accumulation. In most cases it is accompanied by lipid‐free biomass production. Lipid mobilization is a specific process, as preferential degradation of the neutral lipid fractions is observed.
Avoiding Massive Automated Voting in Internet Polls (2008)

Internet polls are becoming nowadays more and more important as they are being used on a large scale. Their security aspects are probably the most significant and hardest issue to be solved when we consider web surveys. In this paper we present an innovative solution which considerably increases the security of Internet polls and the reliability of their results by discriminating between human-cast and machine-cast votes. We define the basic idea of the method used to achieve our goal, its security properties and the testing results on a working prototype. In order to better test the performance and the effective robustness of the solution from the security point of view, we also propose a public challenge.
Generalized Non-metric Multidimensional Scaling. (2007)

We consider the non-metric multidimensional scaling problem: given a set of dissimilarities ∆, find an embedding whose inter-point Euclidean distances have the same ordering as ∆. In this paper, we look at a generalization of this problem in which only a set of order relations of the form dij &lt; dkl are provided. Unlike the original problem, these order relations can be contradictory and need not be specified for all pairs of dissimilarities. We argue that this setting is more natural in some experimental settings and propose an algorithm based on convex optimization techniques to solve this problem. We apply this algorithm to human subject data from a psychophysics experiment concerning how reflectance properties are perceived. We also look at the standard NMDS problem, where a dissimilarity matrix ∆ is provided as input, and show that we can always find an orderrespecting embedding of ∆. 1
Expression and purification of catalytic domain of human macrophage elastase for high throughput inhibitor screening. (2002)

An efficient expression and purification method for hMECD protein has been established, and the assay is effective, reliable, and fast in identifying the recombinant protein inhibitors.
Allogeneic stem cell transplantation (allo-SCT) in adult acute lymphoblastic leukemia (ALL) (2007)

17513 Background: Although viewed as a potentially curable disease, the outcome of adult ALL is extremely poor. The role of allo-SCT, a possible curative modality, is of debate. Although the solid evidence is lacking, allo-SCT is viewed as a standard treatment in some institutions and some trials. The objective of the study is to clarify the effect of allo-SCT in the treatment of adult ALL patietns. Methods: From Jan. 1999 to Jun. 2006, we included 103 adult ALL patients whose age were between 15 and 55, the upper limit of age for allo-SCT in this institution. Their data, including clinical characteristics, cytogenetic results, treatment response and outcomes, were collected. To avoid the “immortal-time bias” in assessing the effect of transplant, the results from a time-independent and time-dependent Cox proportional hazards model were compared. We also conducted a population-based study to compare the outcomes of these patients with those diagnosed between Jan. 1986 and Dec.1993 in our institution. Results: There were 46 females and 57 males. The median age was 25.8, with 63 patients (61.2%) younger than 30. The median survival was 21.9 months and the 3-year overall survival was 34.2%. 48 patients(46.6%) received allo-SCT. The transplant conferred to marginally better survival in univariate analysis (p=0.049), but by time-dependent regression method, there was, after adjusting for other risk factors, no survival benefit for patients receiving transplant (HR 1.452, 95% CI 0.766∼2,751, p=0.253). The outcomes of these 103 patients were compared with another group of 69 patients diagnosed in the early period, among whom 13 patients(18.8%) received transplant. Although with higher proportion of patients undergoing allo- SCT, there was no advance in overall survival (p=0.157). Conclusions: In adult ALL, the outcome is still poor. Although there are new treatment protocols and modalities in chemotherapy and transplantation, these advances do not reflect to survival improvement. Transplantation provides limited survival benefit in population-based viewpoint. The candidates of allo-SCT should thus be carefully selected and allo-SCT should not be viewed as a standard in the treatment of adult ALL patients. No significant financial relationships to disclose.
Analog VLSI and neural systems (invited presentation) (1989)

Children with persistent or refractory middle ear disease who required multiple VTIs were at increased risk of cholesteatoma. First ventilation tubes inserted at an early age, subsequent ventilation tubes inserted without delay, and adenoid removal were associated with a reduced rate of cholesteatoma development.
Comparison of 2D Fingerprint Methods for Multiple‐Template Similarity Searching on Compound Activity Classes of Increasing Structural Diversity (2006)

We studied the similarity search performance of differently designed molecular fingerprints using multiple reference structures and different search strategies. For this purpose, nine compound activity classes were assembled that exclusively consisted of molecules with different core structures and that represented different levels of intra-class structural diversity. Thus, there was a strict one-to-one correspondence between test compounds and core structures. Analysis of unique core structures was found to be a better measure of class diversity than distributions of simplified scaffolds. On increasingly diverse classes, a trainable fingerprint using a unique search strategy performed better than others tested herein. Overall, clear preferences were detected for nearest-neighbor search strategies over fingerprint-averaging techniques. Nearest-neighbor searching that relied on selecting database compounds most similar to one of the reference structures often improved compound recovery over other averaging methods, but at the cost of decreasing the ability to detect hits that were structurally distinct from reference molecules.
Immunocytochemical Localization of Shc and Activated EGF Receptor in Early Endosomes After EGF Stimulation of HeLa Cells (2000)

After binding of epidermal growth factor (EGF), the EGF receptor (EGFR) becomes autophosphorylated via tyrosine. The ligand-activated receptor is internalized by endocytosis and subsequently degraded in the lysosomal pathway. To follow EGFR activation after EGF stimulation, we generated antisera to the EGFR phosphotyrosine sites pY992 and pY1173. The SH2 region of Shc binds to both these sites. Both antisera identified EGFR after EGF binding and did not crossreact with the unactivated receptor. The intracellular distribution of phosphorylated EGFR after ligand binding was traced by two-color immunofluorescence confocal microscopy and immunoelectron microscopy. Before EGF stimulation EGFR was primarily located along the cell surface. When internalization of activated EGFR was inhibited by incubation with EGF on ice, Y992- and Y1173-phosphorylated EGFR were located along the plasma membrane. Ten minutes after internalization at 37C, Y992- and Y1173-phosphorylated EGFR were almost exclusively located in early endosomes, as shown by co-localization with EEA1. Immunoelectron microscopy confirmed that phosphorylated EGFR was located in intracellular vesicles resembling early endosomes. After EGF stimulation, the adaptor protein Shc redistributed to EGFR-containing early endosomes. Our results indicate that EGFR activation of Shc via tyrosine-phosphorylated Y992 and Y1173 occurred in early endocytic compartments, and support a role for membrane trafficking in intracellular signaling.
Selectivity Blocking Contacts and their Application to Microelectronics (1982)

As the size of microelectronic devices are scaled downwards towards ultimate limits, present techniques for forming metallic contacts to different device regions give rise to electronic metallurgical difficulties. This paper describes a class of contacts, which selectively blocks electron or hole current flow between the metal and contacted semiconductor while allowing free passage of the other carrier type. This class of contact may overcome the above difficulties in several applications.
Uncapping the Bottle: A Look Inside the History, Industry, and Regulation of Bottled Water in the United States (2007)

"Agu chupa! Agu chupa!" As we drove through the lush rolling hills of northwestern Rwanda, a crowd of young children appeared from the tea fields and repeatedly shouted these words to us. The taxi driver explained that the children wanted our "water bottes." Aware that visitors often drink bottled water, the children run alongside taxis with the hopes of obtaining the plastic bottles. Although Rwandan children typically carry their drinking water in tightly-woven baskets, the modern plastic bottles have become popular and prized possessions.
ChemInform Abstract: MONOMERE SAUERSTOFF‐ADDUKTE VON N,N′‐AETHYLEN‐BIS‐(ACETYLACETONIMINATO)‐LIGAND‐KOBALT(II), DARST. UND EIGENSCHAFTEN (1970)

Abstract Durch Reaktion des Kobalt(II)‐Komplexes (I) mit den Liganden in nichtwäßrigen Lösungsmitteln und anschließende Umsetzung mit Sauerstoff bei ‐20°C werden die Sauerstoff‐Addukte (II) dargestellt, die IR‐ und elektronenspektroskopisch sowie durch magnetische Messungen charakterisiert werden.
Spontaneous clinical regression in chronic lymphocytic leukaemia (2002)

Chronic lymphocytic leukaemia (CLL) is a B-cell disorder, which has a median survival of over 10 years from diagnosis for stage A disease. The natural history of stage A disease is generally indolent or only slowly progressive. It is less well known that CLL may undergo spontaneous regression. We report a series of 10 such cases (eight stage A and two stage B) followed at our institutions.
Cholesterol’s Aliphatic Side Chain Modulates Membrane Properties (2013)

The influence of cholesterol's alkyl side chain on membrane properties was studied using a series of synthetic cholesterol derivatives without a side chain or with a branched side chain consisting of 5 to 14 carbon atoms. Cholesterol's side chain is crucial for all membrane properties investigated and therefore essential for the membrane properties of eukaryotic cells.