gebhart/patrepeval huggingface dataset:
Relationship of leukocyte CR1 transcript and protein with the pathophysiology and prognosis of systemic lupus erythematosus: A follow-up study (2011)

Complement Receptor 1 (CR1) is a key complement regulatory protein (CRP) involved in the clearance of immune complexes. Earlier, we reported a marked decline of leukocyte CR1 (L-CR1) transcript and protein in patients with active systemic lupus erythematosus (SLE) and suggested L-CR1 transcript as a putative non-invasive disease marker for SLE. This follow-up study involving 18 patients with active SLE was conducted for further confirmation of the relationship between L-CR1 and SLE. Blood samples from the patients were collected on day 1 of the diagnosis (0 month) and at different time intervals (3 and 6 months) for analysis of L-CR1 transcript and L-CR1 protein by semi-quantitative reverse-transcriptase-polymerase chain reaction (RT-PCR) and western blotting respectively. Within 6 months, 15 patients entered remission. On day 1, the mean values of L-CR1 transcript (8.42 ± 3.53) and L-CR1 protein (4683 ± 1094) in the SLE patients were 6 times and 12 times lower than the normal controls (n = 103). At the end of month 6, these values increased by 4.5 and 6.5 times respectively for CR1 transcript (37.86 ± 8.52) and protein (30,265 ± 8614). Simultaneously, the SLE Disease Activity Index (SLEDAI) scores decreased by 4.8 times (4.47 ± 3.32) as compared with the scores obtained on day 1 (21.45 ± 5.67). Moreover, CR1 values correlated negatively with the SLEDAI scores. Levels of L-CR1 protein and transcript remained low in the three patients who did not enter remission. All of the above results suggested that an increase in the levels of L-CR1 related to good prognosis. Since the levels of L-CR1 protein is influenced by variables like proteolytic cleavage and secretion from leukocytes, the values of L-CR1 transcript on day 1 and subsequent follow-up points may bring a better insight into the state of the disease activity. An extended follow-up study is needed to confirm the significance of L-CR1 as a prognostic marker for SLE.
Differential Effects of Cystathionine-γ-lyase–Dependent Vasodilatory H2S in Periadventitial Vasoregulation of Rat and Mouse Aortas (2012)

Our results demonstrate potent vasorelaxant effects of H(2)S donors in large arteries of both rats and mice, in which XE991-sensitive KCNQ-type channel opening play a pivotal role. CSE-H(2)S seems to modulate the effect of adipocyte-derived relaxing factor in rat but not in mouse aorta. The present study provides novel insight into the interaction of CSE-H(2)S and perivascular adipose tissue. Furthermore, with additional technical advances, a future clinical approach targeting vascular H(2)S/KCNQ pathways to influence states of vascular dysfunction may be possible.
INTERNATIONAL ABSTRACTS OF PLASTIC AND RECONSTRUCTIVE SURGERY (1965)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
Diffuse CNS involvement in systemic lupus erythematosus (1990)

In extracerebral systemic lupus erythematosus (SLE), the complement system plays a prominent pathogenic role, and decreased serum concentration of the 4th component (C4) is a reliable indicator of systemic disease activity. In diffuse CNS-SLE, however, the pathogenic role of complement is less clear. In 12 patients with active diffuse CNS-SLE presenting with delirium (4), organic personality syndrome (3), or generalized seizures (5), we determined the CSF indexes of the complement components C3, C4, and factor B, and of IgG, IgA, and IgM. There was a significant increase of the C4 index in these patients compared with controls and a significantly higher CSF C4 index in patients with an increased IgM index. We conclude that intrathecal C4 is being produced in diffuse CNS-SLE.
Analysis of coupling noise in dynamic circuit (2004)

Noise has become an important metric of deep submicron digital integrated circuit performance, and is becoming even more prominent due to the increasing usage of noise sensitive dynamic circuits for speed and area requirements. This paper presents closed form analytical solutions for noise as well as noise tolerance metrics for dynamic circuits to analyze the effects of coupling, which is considered as the dominant source of noise. These solutions are within 5% of dynamic simulations. It is shown that not all the scaling trends are negative for noise, and that the scaling down of supply voltage and increasing frequency help improve certain aspects of the noise immunity of dynamic circuit. Most of the work treated noise immunity and the noise content separately. This paper introduces a positive analysis of noise scalability by looking at the noise immunity and the noise content simultaneously.
Co-operative actions and degradation analysis of purified xylan-degrading enzymes from Thermomonospora fusca BD25 on oat-spelt xylan (2003)

The results highlight the role of xylan de-branching enzymes in the degradation of xylan and suggest that the use of enzyme cocktails may significantly improve the hydrolysis of xylan in industrial processes.
Optimization of Lipid-Mediated Ribozyme Delivery to Cells in Culture (2003)

Ribozymes have considerable potential as agents to modify gene expression. Strategies have recently been reported for modifying synthetic hammerhead ribozymes to render them nuclease-resistant while retaining catalytic activity (1). Modified ribozymes therefore offer promise as therapeutics. An important component in obtaining efficacy of a ribozyme on its intracellular target is the ability to introduce the ribozyme into the cell efficiently and reproducibly. Although cells in culture will take up free oligonucleotide via endocytosis (2), the process is inefficient and usually does not result in an efficacious dose being delivered. Thus, many methods have been described for enhancing this process. Cationic lipid-mediated delivery of plasmid DNA into a cell was first described by Feigner et al. (3). In the last several years, cationic lipids have been used extensively to enhance cellular uptake of DNA and RNA. Cationic lipids can interact with the negatively charged phosphate groups on DNA or RNA to form a lipid-DNA (RNA) complex. When incubated with cells, these complexes are believed to fuse with the cell membrane (4) or more likely undergo endocytosis (5).
Heterogeneity of serum tryptophan concentration and availability to the brain in patients with the chronic fatigue syndrome (2005)

We assessed the serotonin status of patients with the chronic fatigue syndrome (CFS). Tryptophan (Trp) availability to the brain, expressed as the ratio of concentration of serum Trp to the sum of those of its five competitors (CAA), and other parameters of Trp disposition were compared in 23 patients with the CFS and 42 healthy controls. The serum [free Trp]/[CAA] ratio was 43% higher in CFS patients, due to a 48% higher [free Trp]. [Total Trp] was also significantly higher (by 19%) in CFS patients, and, although the [total Trp]/[CAA] ratio did not differ significantly between the control and patient groups, the difference became significant when the results were co-varied with age and gender. [CAA] was not significantly different between groups, but was significantly lower in females, compared to males, of the CFS patient group. We have established normal ranges for Trp disposition parameters and propose criteria for defining the serotonin-biosynthetic status in humans. We have provisionally identified two subgroups of CFS patients, one with normal serotonin and the other with a high serotonin status. The relevance of our findings to, and their implications for, the pharmacological and other therapies of the chronic fatigue syndrome are discussed.
Enabling new services by exploiting presence and context information in IMS (2006)

The IP Multimedia Subsystem (IMS) architecture enables a new class of converged, multimedia services for subscribers. This paper examines the role of presence information in IMS to provide personalized treatment of voice over Internet Protocol (VoIP) calls, multimedia sessions, and instant messaging (IM) interactions. This can be achieved with an IMS application server that interacts in a standardized way with IMS elements (S-CSCF and HSS) and other elements such as the MiLife™ presence server. In addition, we propose a generalized architecture that extends the presence concept to a broader class of context information. Based on selected use cases, we identify required presence and context attributes (e.g., source, real-time availability, and lifetime) and their characteristics. This paper also addresses how these attributes can be gathered, monitored, filtered, and stored efficiently using a hierarchical architecture. This includes incorporation of external presence and context information, such as emergency and enterprise calendar data, in a secure and privacy-sensitive manner.
Quasistatic deformation and failure modes of composite square honeycombs (2008)

Carbon fibre epoxy matrix composite honeycombs have been fabricated by slotting, assembling and adhesively bonding composite laminate sheets with various fibre architectures. Their out-of-plane compressive and in-plane shear responses were measured as a function of relative density, ratio of the cell height to width and the number of cells in the specimen. The measurements indicate that the response is relatively insensitive to the ratio of the cell height to cell width and number of cells in the specimen but is strongly dependent on the laminate type and fibre orientation. For example, the compressive strength of the honeycombs made from 0 -90 laminates with fibres aligned with the compression direction was greater than that of honeycombs made from a woven material with fibres at 45 . However, the shear strengths exhibited the opposite trend. These differences were attributed to a change in failure mode. In compression the honeycombs failed by either elastic buckling or plastic microbuckling while in shear the two main failure modes were elastic buckling or shear failure of the composite sheet material. Analytical models are derived for these collapse modes and used to predict the strength of the honeycomb structure. The predicted strengths are substantially higher than the measurements due to the presence of manufacturing imperfections in the honeycombs that are not accounted for in the analytical models. A limited finite element (FE) investigation is also reported to quantify the effects of imperfections on the compressive strength of the composite honeycombs. The measurements and analytical predictions reported here indicate that composite cellular materials such as honeycombs reside in a gap in the strength versus density material property space, providing new opportunities for lightweight, high strength structural design.
Calixarenes. 24. Complexation by water-soluble calixarenes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCalixarenes. 24. Complexation by water-soluble calixarenesIftikhar Alam and C. David GutscheCite this: J. Org. Chem. 1990, 55, 14, 4487–4489Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/jo00301a057https://doi.org/10.1021/jo00301a057research-articleACS PublicationsRequest reuse permissionsArticle Views470Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Valid inequalities for the fleet size and mix vehicle routing problem with fixed costs (2009)

Abstract In the well‐known vehicle routing problem (VRP), a set of identical vehicles located at a central depot is to be optimally routed to supply customers with known demands subject to vehicle capacity constraints. An important variant of the VRP arises when a mixed fleet of vehicles, characterized by different capacities and costs, is available for distribution activities. The problem is known as fleet size and mix VRP with fixed costs FSMF and has several practical applications. In this article, we present a new mixed integer programming formulation for FSMF based on a two‐commodity network flow approach. New valid inequalities are proposed to strengthen the linear programming relaxation of the mathematical formulation. The effectiveness of the proposed cuts is extensively tested on benchmark instances. © 2009 Wiley Periodicals, Inc. NETWORKS, 2009
The effect of electron withdrawing croups on the stability of thiabenzenes (1977)

Abstract The reactions of p ‐trifluoromethylphenyllithium with 2,4,6‐triarylthiopyrylium perehlorates (Ar = Ph, p ‐CH 3 OC 6 H 4 , p ‐NMe 2 C 6 H 4 ) have been studied. The initially formed thiabenzenes were not slable enough to he isolated and rearranged readily to their corresponding 4‐( p ‐tri‐fluoromethylphenyl)‐2,4,6‐triarylthiopyrans. The instability of the intermediate thiabenzenes reveals that, in contrast to the stabilization effect of the electron‐withdrawing p ‐chloro‐ and pentalluorophcnyl groups attached to carbon atoms in sulfur ring, the electron‐withdrawing p ‐lrilluoromethyl group on subsliluenls attached to sulfur decreases the stability of thiabenzenes.
Effects of sulfur-containing analogs of stearic acid on growth and fatty acid biosynthesis in the protozoan Crithidia fasciculata (1988)

A variety of analogues of stearic acid in which one of the methylene groups was replaced by a sulfur atom were examined as inhibitors of growth and fatty acid biosynthesis in the trypanosomatid protozoan Crithidia fasciculata. The 8-, 9-, 10-, and 11-thiastearic acids were found to suppress the synthesis of the cyclopropane-containing fatty acid dihydrosterculic acid (9,10-methyleneoctadecanoic acid) at micromolar concentrations in the growth medium, and all but the 9-thiastearate were found to inhibit the growth of the protozoa at concentrations. The most potent inhibitor, 8-thiastearic acid (I50 for growth = 0.8 microM; I50 dihydrosterculate synthesis = 0.4 microM), was also observed to inhibit the synthesis of gamma-linolenic acid at a similar concentration. The sulfoxide derivatives of the 9- and 10-thiastearates were found to have little effect on growth or fatty acid synthesis, and several long-chain amides of 3-amino-1,2-propanediol were found to have effects similar to those of the fatty acids from which they were derived.
The effects of icing on the longitudinal dynamics of an icing research aircraft (1999)

Icing affects the aerodynamic performance of aircraft leading sometimes resulting in catastrophic crashes. The effects of icing have been studied in the past but from more of an aerodynamicist’s viewpoint than a flight controls viewpoint. This paper develops models for aircraft dynamics in the presence of icing that can ultimately lead to a model based method of detecting icing. Flight test data from the NASA Lewis Twin Otter Icing Research Aircraft is analyzed in both case of a nominal un-iced configuration and a horizontal stabilizer experiencing icing due to a failed de-icing boot. Robust global nonlinear models were developed for each flap setting. The global nonlinear and localized linear models were analyzed for the differences between nominal and iced conditions with excellent agreement between model predictions and flight test data.
Impact of Stacked AlON/SiO<sub>2</sub> Gate Dielectrics for SiC Power Devices (2011)

Abstract not Available.
Modal Analysis of Homogeneous Optical Fibers with Deformed Boundaries (1979)

The modal characteristics of homogeneous optical fibers with several types of deformed boundaries are analyzed by a numerical method on the point-matching principle. The propagation constants of various modes are given. The separation of degeneracy in the dominant is discussed. The results of microwave-model experiments show good agreement with those of calculation.
Characterization of Glucose Oxidase-Modified Poly(phenylenediamine)-Coated Electrodes in vitro and in vivo: Homogeneous Interference by Ascorbic Acid in Hydrogen Peroxide Detection (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of Glucose Oxidase-Modified Poly(phenylenediamine)-Coated Electrodes in vitro and in vivo: Homogeneous Interference by Ascorbic Acid in Hydrogen Peroxide DetectionJohn P. Lowry, Karl. McAteer, Satea S. El Atrash, Adrienne. Duff, and Robert D. O'NeillCite this: Anal. Chem. 1994, 66, 10, 1754–1761Publication Date (Print):May 15, 1994Publication History Published online1 May 2002Published inissue 15 May 1994https://pubs.acs.org/doi/10.1021/ac00082a025https://doi.org/10.1021/ac00082a025research-articleACS PublicationsRequest reuse permissionsArticle Views920Altmetric-Citations156LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Microcomputer-Controlled Precision Pneumatic Pressure Generator (1977)

An increasing variety of avionics require precision pneumatic pressure stimuli during organization and intermediate maintenance. The accuracy and long-term stability requirements approach the best mercurial standards. Pressure stimuli must be coordinated and varied at precise rates that are beyond the frequency response of mercury columns and many electromechanical sensors. Test systems are frequently required to simultaneously monitor and evaluate unit under test (UUT) response and generate pneumatic stimuli. In addition, the environment is frequently hostile, maintainability is paramount, performance must always be known and warmup time must be nil. Comprehensive trade studies, tests, and analyses were performed. This initial work indicated a new pressure generator should be a "smart" instrument and should use a pressure sensor not a density sensor. Current field and production experience indicates performance objectives have been exceeded and this new type of precision pressure generator can be readily incorporated in a variety of test systems or be used "stand-alone". This paper discusses the design implementation, features, and characteristics of this microcomputer controlled precision pneumatic pressure generator-a new "smart" test instrument.
SRbench--a benchmark for soundtrack recommendation systems (2013)

In this work, a benchmark to evaluate the retrieval performance of soundtrack recommendation systems is proposed. Such systems aim at finding songs that are played as background music for a given set of images. The proposed benchmark is based on preference judgments, where relevance is considered a continuous ordinal variable and judgments are collected for pairs of songs with respect to a query (i.e., set of images). To capture a wide variety of songs and images, we use a large space of possible music genres, different emotions expressed through music, and various query-image themes. The benchmark consists of two types of relevance assessments: (i) judgments obtained from a user study, that serve as a ``gold standard'' for (ii) relevance judgments gathered through Amazon's Mechanical Turk. We report on the performance of two state-of-the-art soundtrack recommendation systems using the proposed benchmark.
Photochemistry and photopolymerization activity of perester derivatives of benzophenone (1991)

Abstract The spectroscopic properties and photopolymerization activities of a mono‐ and tetraperester derivative of benzophenone are examined and compared with those of benzophenone. Their photopolymerization activity in methyl methacrylate (MMA) and an ethoxylated bis‐phenol‐A diacrylate have been studied using a combination of gel permeation chromatography (GPC), and real time Fourier transform infrared spectroscopy (RTFTIR) as well as the commercial pendulum hardness test. Using GPC analysis on the poly(methyl methacrylate) samples the tetra‐‐t‐ butyl perester derivative of benzophenone is found to give a higher weight average ( M w ) and number average ( M n ) molecular weight polymer than that produced using the mono perester. For the two peresters of benzophenone photopolymerization efficiency using real time FTIR increases with increasing initiator concentration, and no self‐termination is observed up to 0.75% w/w concentration with the mono perester derivative being the more efficient initiator. Similar results were obtained using the commercial pendulum hardness tester with a triacrylate/epoxyurethane acrylate resin with benzophenone exhibiting the lowest activity. Photopolymerization activities of the initiators correlate well with their spectroscopic properties. The phosphorescence quantum yield is higher for the monoperester than the tetraperester derivative and is consistent with a shorter lifetime and lower photolysis quantum yields in 2‐propanol. Compared with benzophenone, phosphorescence analysis indicates that the perester groups impart a degree of charge‐transfer content to the molecule which is consistent with the degree of substitution. Ketyl radical formation on microsecond flash photolysis follows the order benzophenone > mono‐ > tetraperester derivative and is consistent with the phosphorescence quantum yields. On nanosecond laser flash photolysis in nitrogen‐saturated acetonitrile, triplettriplet absorption is extremely weak for both the perester derivatives, being stronger for the monoperester.