gebhart/patrepeval huggingface dataset:
Nasal Reaction to Changes in Whole Body Temperature (1993)

The changes in nasal patency following a 1.5 degrees C decrease or increase in whole body temperature were measured in 8 healthy young males, during and after 30 min of immersion in a 15 degrees C cold or a 40 degrees C warm bath, breathing air at the same temperature, in a cross-over experimental design. The nasal reactions were traced by consecutive measurements of changes in nasal cavity volumes by acoustic rhinometry. Swelling of the mucosa during cooling and an almost maximal shrinkage of the mucosa during heating were indicated by respectively a decrease and an increase in nasal cavity volumes. The reactions were determined predominantly by the whole body thermal balance, but were also influenced by the temperature of the inhaled air, either enhanced, reduced or temporarily reversed. The greatest change occurred in the nasal cavity, left or right, which differed most from the final state at the beginning of exposure due to the actual state of nasal cycle.
Toward high-efficiency solar upconversion with plasmonic nanostructures (2012)

Upconversion of sub-bandgap photons can increase the maximum efficiency of a single-junction solar cell from 30% to over 44%. However, upconverting materials often have small absorption cross-sections and poor radiative recombination efficiencies that limit their utility in solar applications. Here, we show that the efficiency of upconversion can be substantially enhanced with a suitably designed plasmonic nanostructure. The structure consists of a spherical nanocrescent composed of an upconverter-doped dielectric core and a crescent-shaped metallic shell. Using numerical techniques, we calculate a greater than 10-fold absorption enhancement for a broad range of sub-bandgap wavelengths throughout the entire upconverting core. Further, this nanocrescent enables a 100-fold increase in above-bandgap power emission toward the solar cell. Our results provide a framework for achieving low-power solar upconversion, potentially enabling a single-junction solar cell with an efficiency exceeding the Shockley–Queisser limit.
Nonautologous Interbody Fusion Materials in Cervical Spine Surgery (2001)

There is limited evidence supporting the use of a cervical interbody fusion device in place of autologous bone. There is a need to standardize the testing of implants with good quality laboratory work preceding clinical use. Certain devices including cages, some forms of hydroxyapatite, and bone morphogenic proteins merit further study.
Molecular pathways in myelodysplastic syndromes and acute myeloid leukemia: relationships and distinctions–a review (2008)

The myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are both hematopoietic stem cell disorders. However, while leukemic stem cells have been revealed by clonal tracking experiments, dysplastic stem cells have never been demonstrated by xeno-transplantation assays because of poor engraftment problems. These engraftment difficulties may be due to the unique nature of MDS genetic lesions that are truly able to recapitulate the disease phenotype. MDS and AML of younger patients harbour clonal yet different chromosomal markers, whereas MDS and AML of the elderly present similar defects. Potential involvement of tumor suppressor genes in MDS has been hypothesized but never confirmed, while cooperation between class I and class II mutations has been identified in AML. The reciprocal interactions between stromal cells and neoplastic clones are disrupted in both MDS and AML. In early MDS, stromal and neoplastic cells produce high levels of inhibitory cytokines, whereas in advanced MDS and AML they produce high levels of anti-apoptotic molecules.
E.-J. Sharpe. Not to destroy but to fulfil (1968)

Robert Daniel. E.-J. Sharpe. Not to destroy but to fulfil. In: Revue de l'histoire des religions, tome 174, n°1, 1968. pp. 111-112.
Stability of Crossed-Field Electron Beams (1966)

The stability of crossed-field electron beams is treated for arbitrary values of the parameter q=ωp2/ωc2 = (plasma frequency/cyclotron frequency)2. The theory bridges a gap between existing theories applicable for q«1 and for q=1. For wavelengths longer than about five beam thicknesses an instability occurs with a growth rate not exceeding ∼¼qωc. It can be shorted out by conducting walls, or else one can prevent long wavelengths in closed (cylindrical or toroidal) beam geometries. For wavelengths shorter than roughly 6q beam thicknesses a cyclotron instability occurs with a growth rate ∼½qωc exp(−2/q). This becomes practically unimportant for q⪝0.2. Observations support these theoretical results.
Arylsulfatases isoenzymes in metachromatic leucodystrophy/detection of a new variant by electrophoresis improvement of quantitative assay. (1975)

<P>Abstract copyright UK Data Service and data collection copyright owner.</P>
Nefopam HCl Interaction Study with Eight other Drugs (1976)

A controlled clinical trial was undertaken to determine potential for drug interaction of nefopam HCl, a new analgesic, with eight other widely used compounds. Nefopam HCl was administered in combination with these drugs and placebo to forty-five healthy volunteer subjects in nine groups of five subjects each. Possible drug interactions were detected by the occurrence of side-effects and interference with bioavailability of the new analgesic, also by changes in vital signs or in various laboratory tests. Results indicated no statistically significant differences in these parameters between the nefopam HCl-placebo regimen and the other eight combinations. Despite this, there were substantial clinical differences in the intensity and incidence of side-effects with combinations of codeine, pentazocine and propoxyphene. These differences warrant further study. Serum nefopam HCl levels were significantly higher on Day 3 than on Day 1, indicating no defect in bioavailability due to drug interaction. Overall, results of this study support the feasibility of concomitant use of these eight drugs with nefopam HCl for short treatment periods.
Histological and immunohistochemical studies of tissue engineered odontogenesis (2005)

The successful regeneration of complex tooth structures based on tissue-engineering principles was recently reported. The process of this regeneration, however, remains poorly characterized. In this study, we have used histochemistry to examine the regeneration process of tissue engineered teeth in order to determine the cell types that give rise to these engineered tooth structures. Porcine third molar tooth buds were dissociated into single-cell suspensions and seeded onto a biodegradable polyglycolic acid polymer scaffold. Following varying periods of growth in rat hosts, the specimens were evaluated by histology and immunohistochemistry. Aggregates of epithelial cells were first observed 4-6 weeks after implantation. These aggregates assumed three different shapes: a natural tooth germ-like shape, a circular shape, or a bilayer-bundle. Based on the structure of the stellate reticulum in the dental epithelium, the circular and bilayer-bundle aggregates could be clearly classified into two types: one with extensively developed stellate reticulum, and the other with negligible stellate reticulum. The epithelial cells in the circular aggregates differentiated into ameloblasts. The continuous bilayer bundles eventually formed the epithelial sheath, and dentin tissue was evident at the apex of these bundles. Finally, enamel-covered dentin and cementum-covered dentin formed, a process most likely mediated by epithelial-mesenchymal interaction. These results suggest that the development of these engineered teeth closely parallels that of natural odontogenesis derived from the immature epithelial and mesenchymal cells.
The cardiac anti-adrenergic effect of adenosine. (1987)

Adenosine has an anti-adrenergic action in the heart and appears to serve as negative-feedback modulator of beta-adrenoceptor-mediated myocardial contractile and metabolic responses. This action of adenosine has been assessed in various heart preparations by the application of exogenous adenosine, the determination of tissue and coronary venous effluent levels of adenosine and the degradation of endogenous adenosine by adenosine deaminase. The evidence suggests that the anti-adrenergic function of adenosine has vital physiological and clinical implications in the normoxic, hypoxic and ischemic myocardium.
Heart-Rate Recommendations: Transfer Between Running and Cycling Exercise? (2003)

With the expanding use of portable heart rate (HR) monitors in endurance sports, HR is increasingly used as a marker for exercise intensity. Hereby, HR at the so-called individual anaerobic threshold (IAT) is one possible reference point. However, once determined, it is often attempted to apply HR recommendations from one type of ergometry to different kinds of exercises. We examined whether HR at IAT and at 4 mmol x l -1 blood lactate is predictable from cycling to running and vice versa. Data of 371 subjects (304 male, 67 female) were analyzed. All subjects underwent an incremental test on a treadmill (TR, starting speed 6 or 8 km x h -1, increments 2 km x h -1 every 3 min) and on a bicycle ergometer (BE, start at 50 Watt, increments 25 or 50 Watt every 3 min). IAT was determined at a net increase of lactate concentration of 1 - 5 mmol x l -1 above lactate concentration at lactate threshold for running (as in: Med Sci Sports Exerc 1998, 30 (10); 1552 - 1557) and 1.0 mmol x l -1 for cycling. A maximum time span of three weeks was allowed between the tests. We found that heart rate at IAT or at 4 mmol x l -1 blood lactate did not correlate between cycling and running. A sports specific test seems to be a prerequisite for reliable heart rate recommendations.
Selective Transplantation (1985)

The purpose of this paper is to call attention to a number of approaches that have recently become attractive for the treatment of donor organs or tissues prior to transplantation in such a way that they succeed better as transplants thereafter. These treatments are designed to select from an organ or tissue those cellular elements required for the express purposes of the transplant. Three sets of examples of "selective transplantation" are offered; those that focus upon the maintenance of mechanical functions of the donor tissue, those in which metabolic properties of the graft are paramount, and those in which immunological considerations are primary. Although it is predicted that the selective approach described will prove to be useful in a variety of clinical settings, the full extent of its applicability remains to be demonstrated.
<title>Polychromatic neural networks</title> (1991)

A polychromatic optical neural network using cascaded liquid crystal televisions (LCTV) that uses a polychromatic interconnection weight matrix (IWM) for color pattern recognition is presented and simulated. Extension of the polychromatic neural net for multichannel operation is proposed.
Enhancing the trust of internet routing with lightweight route attestation (2011)

The weak trust model in Border Gateway Protocol (BGP) introduces severe vulnerabilities for Internet routing including active malicious attacks and unintended misconfigurations. Although various secure BGP solutions have been proposed, they share similar weaknesses such as high complexity of security enforcement and incapability of data-plane attack prevention. We propose TBGP, a trusted BGP scheme aiming to achieve high authenticity of Internet routing with a simple and lightweight attestation mechanism. TBGP introduces a set of route update and withdrawal rules that, if correctly enforced by each router, can guarantee the authenticity and integrity of route information that is announced to other routers in the Internet. Through this, TBGP builds a transitive trust relationship among all routers on a routing path. We implement a prototype of TBGP to investigate its practicality. In our implementation, we use identity-based signature (IBS) and trusted computing (TC) techniques to further reduce the complexity of security operations. The performance study show that TBGP can achieve significantly better convergence performance and lower computation overhead than existing secure BGP solutions.
Silk sericin and its applications: A review (2004)

Silk consists of two types of proteins, silk fibroin and sericin. Sericin contributes about 20-30 per cent of total cocoon weight. It is characterized by its high content of serine and 18 amino acids, including essential amino acids. There are different methods of isolation of sericin from silk thread. Solubility, molecular weight, and gelling properties of sericin depend on the method of isolation. It has wide applications in pharmaceuticals and cosmetics such as, wound healing, bioadhesive moisturizing, antiwrinkle and antiaging.
Nanocrystalline TiO<sub>2</sub> Photocatalytic Membranes with a Hierarchical Mesoporous Multilayer Structure: Synthesis, Characterization, and Multifunction (2006)

Abstract A novel sol–gel dip‐coating process to fabricate nanocrystalline TiO 2 photocatalytic membranes with a robust hierarchical mesoporous multilayer and improved performance has been studied. Various titania sols containing poly(oxyethylenesorbitan monooleate) (Tween 80) surfactant as a pore‐directing agent to tailor‐design the porous structure of TiO 2 materials at different molar ratios of Tween 80/isopropyl alcohol/acetic acid/titanium tetraisopropoxide = R :45:6:1 have been synthesized. The sols are dip‐coated on top of a homemade porous alumina substrate to fabricate TiO 2 /Al 2 O 3 composite membranes, dried, and calcined, and this procedure is repeated with varying sols in succession. The resulting asymmetric mesoporous TiO 2 membrane with a thickness of 0.9 μm exhibits a hierarchical change in pore diameter from 2–6, through 3–8, to 5–11 nm from the top to the bottom layer. Moreover, the corresponding porosity is incremented from 46.2, through 56.7, to 69.3 %. Compared to a repeated‐coating process using a single sol, the hierarchical multilayer process improves water permeability significantly without sacrificing the organic retention and photocatalytic activity of the TiO 2 membranes. The prepared TiO 2 photocatalytic membrane has great potential in developing highly efficient water treatment and reuse systems, for example, decomposition of organic pollutants, inactivation of pathogenic microorganisms, physical separation of contaminants, and self‐antifouling action because of its multifunctional capability.
Electron microscopy of embryonic human epidermis at seven and ten weeks. (1969)

No abstract available
Cloning and expression of the Mycobacterium fortuitum Superoxide dismutase gene (1995)

In this paper we report the cloning, sequencing and expression of the Superoxide dismutase (sod) gene from Mycobacterium fortuitum. A single gene was found to code for Superoxide dismutase activity with its identity being confirmed by expression in M. aurum. The amino acid sequence was found to be similar to that of Superoxide dismutases of several other origins. A region downstream of the sod gene also showed similarities to the corresponding sequences of the two main mycobacterial pathogens: M. leprae and M. tuberculosis. Analysis of enzymatic activity showed this enzyme in M. fortuitum required manganese as cofactor.
Unusual Magnetic State in Lithium-Doped<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mrow><mml:mi mathvariant="normal">M</mml:mi><mml:mi mathvariant="normal">o</mml:mi><mml:mi mathvariant="normal">S</mml:mi></mml:mrow><mml:mn>2</mml:mn></mml:msub></mml:math>Nanotubes (2003)

We report on the very peculiar magnetic properties of an ensemble of very weakly coupled lithium-doped MoS2 nanotubes. The magnetic susceptibility chi of the system is nearly 3 orders of magnitude greater than in typical Pauli metals, yet there is no evidence for any instability which would alleviate this highly frustrated state. Instead, the material exhibits peculiar paramagnetic stability down to very low temperatures, with no evidence of a quantum critical point as T-->0 in spite of clear evidence for strongly correlated electron behavior. The exceptionally weak intertube interactions appear to lead to a realization of a near-ideal one-dimensional state in which fluctuations prevent the system from reordering magnetically or structurally.
Evaluating school performance tools and approaches : putting self-evaluation in place (2000)

School self-evaluation lays the groundwork and opens doors to self-driven school improvement. This booklet provides insights in to school self-evaluation and offers a number of tools to conduct self-evaluation. Self-evaluation provides schools with the opportunity to listen to teachers, parents, and pupils: to gain their views about what the school is, and what it could be, and to use that information to make changes. There are seven important steps to the self-evaluating school: a) promote a learning climate; b) identify the green shoots of growth; c) identify the barriers to change; d) share leadership; e) create intelligence from within; f) use 'critical' friends; and g) build resilient networks. In developing school self-evaluation, it takes time to build trust and a shared culture. It may provoke some anxiety and resistance at the outset. But in general it creates energy rather than dissipates it.
Comparison between 1-deoxynojirimycin and <i>N</i>-methyl-1-deoxynojirimycin as inhibitors of oligosaccharide processing in intestinal epithelial cells (1985)

The alpha-glucosidase inhibitor N-methyl-1-deoxynojirimycin (MDJN) inhibits the synthesis of N-linked complex oligosaccharides in rat intestinal epithelial cells to the same extent as reported previously for 1-deoxynojirimycin (DJN) [Saunier, Kilker, Tkacz, Quaroni & Herscovics (1982) J. Biol. Chem. 257, 14155-14161]. Analysis of each of the endo-beta-N-acetylglucosaminidase H (endo H)-sensitive oligosaccharides separated by h.p.l.c. with yeast glucosidase I, which specifically removes the terminal glucose residue from oligosaccharides containing three glucose residues, and with jack-bean (Canavalia ensiformis) alpha-mannosidase, indicates that both inhibitors cause the accumulation of a mixture of glucosylated oligosaccharides containing one to three glucose residues and seven to nine, and even possibly six, mannose residues. About 70% of the endo H-sensitive oligosaccharides formed in the presence of MDJN contain three glucose residues, compared with only about 20% of the corresponding oligosaccharides of the DJN treated cells. It is concluded that both compounds inhibit the formation of N-linked complex oligosaccharides by interfering with the processing glucosidases. These compounds are valuable in the study of the role of oligosaccharides in glycoproteins.
Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development (2001)

Runx (Cbfa/AML) transcription factors are critical for tissue-specific gene expression. A unique targeting signal in the C terminus directs Runx factors to discrete foci within the nucleus. Using Runx2/CBFA1/AML3 and its essential role in osteogenesis as a model, we investigated the fundamental importance of fidelity of subnuclear localization for tissue differentiating activity by deleting the intranuclear targeting signal via homologous recombination. Mice homozygous for the deletion (Runx2 Delta C) do not form bone due to maturational arrest of osteoblasts. Heterozygotes do not develop clavicles, but are otherwise normal. These phenotypes are indistinguishable from those of the homozygous and heterozygous null mutants, indicating that the intranuclear targeting signal is a critical determinant for function. The expressed truncated Runx2 Delta C protein enters the nucleus and retains normal DNA binding activity, but shows complete loss of intranuclear targeting. These results demonstrate that the multifunctional N-terminal region of the Runx2 protein is not sufficient for biological activity. We conclude that subnuclear localization of Runx factors in specific foci together with associated regulatory functions is essential for control of Runx-dependent genes involved in tissue differentiation during embryonic development.
Semantics-enabled web APIs selection patterns (2011)

The design of Web applications from third-party Web APIs can be shortened by providing effective tools that abstract from heterogeneity of Web API descriptions and support the designer for their proactive selection. In this paper, we identify Web API selection patterns to support interactive and proactive Web application development according to an exploratory perspective. Selection patterns rely on a semantic characterization of Web API descriptions that abstracts from implementation details and semantics-enabled metrics for evaluation of coupling and similarity degree. A prototype tool that implements selection patterns is also presented.
Slip Casting of SiC‐Whisker‐Reinforced Si <sub>3</sub> N <sub>4</sub> (1989)

Si 3 N 4 composite materials containing up to 20 vol% SiC whiskers were slip cast and pressureless sintered at 1820°C and 0.13 MPa of N 2 . Viscosimetry showed no influence of whisker loading on the rheology of the highly concentrated aqueous slips up to 15 vol% whiskers. During casting the whiskers were preferentially aligned parallel to the mold surfaces. Depending on the whisker loading, green densities of 0.64 to 0.69 fractional density could be achieved. Strong anisotropic shrinkage occurred during sintering with a maximum linear shrinkage of 21% perpendicular but only 7% parallel to the whisker plane. With increasing whisker content from 0 to 20 vol% sintered densities decreased from 0.98 to 0.88, respectively.
Moving object tracking using active models (2002)

We propose a model based tracking algorithm which can extract trajectory information of a target object by detecting and tracking a moving object from a sequence of images. The algorithm constructs a model from the detected moving object and match the model with successive image frames to track the target object. We use an active model which characterizes regional and structural features of a target object such as shape, texture, color, and edge. Our active model can adapt itself dynamically to an image sequence so that it can track a non-rigid moving object. Such an adaptation is made under the framework of energy minimization. We design an energy function so that the function can embody structural attributes of a target as well as its spectral attributes. We applied a Kalman filter to predict motion information. The predicted motion information by Kalman filter was used very efficiently to reduce the search space in the matching process.
Genetic Architecture of Flowering Time in Maize As Inferred From Quantitative Trait Loci Meta-analysis and Synteny Conservation With the Rice Genome (2004)

Genetic architecture of flowering time in maize was addressed by synthesizing a total of 313 quantitative trait loci (QTL) available for this trait. These were analyzed first with an overview statistic that highlighted regions of key importance and then with a meta-analysis method that yielded a synthetic genetic model with 62 consensus QTL. Six of these displayed a major effect. Meta-analysis led in this case to a twofold increase in the precision in QTL position estimation, when compared to the most precise initial QTL position within the corresponding region. The 62 consensus QTL were compared first to the positions of the few flowering-time candidate genes that have been mapped in maize. We then projected rice candidate genes onto the maize genome using a synteny conservation approach based on comparative mapping between the maize genetic map and japonica rice physical map. This yielded 19 associations between maize QTL and genes involved in flowering time in rice and in Arabidopsis. Results suggest that the combination of meta-analysis within a species of interest and synteny-based projections from a related model plant can be an efficient strategy for identifying new candidate genes for trait variation.