gebhart/patrepeval huggingface dataset:
Optimized Preparation Method of Platelet-Concentrated Plasma and Noncoagulating Platelet-Derived Factor Concentrates: Maximization of Platelet Concentration and Removal of Fibrinogen (2011)

Platelet-rich plasma (PRP) has been clinically used as an easily prepared growth factor cocktail that can promote wound healing, angiogenesis, and tissue remodeling. However, the therapeutic effects of PRP are still controversial, due partly to the lack of optimized and standardized preparation protocols. We used whole blood (WB) samples to optimize the preparation protocols for PRP, white blood cell-containing (W-PRP), platelet-concentrated plasma (PCP), and noncoagulating platelet-derived factor concentrate (PFC). PRP and W-PRP were most efficiently collected by 10 min centrifugation in a 15-mL conical tube at 230-270 g and 70 g, respectively. To prepare PCP, platelets were precipitated by centrifugation of PRP at >2300 g, 90% of supernatant plasma was removed, and the platelets were resuspended. For preparation of noncoagulating PFC, the supernatant was replaced with one-tenth volume of saline, followed by platelet activation with thrombin. Platelet (before activation) and platelet-derived growth factor (PDGF)-BB (after activation) concentrations in PCP were approximately 20 times greater than those in WB, whereas PFC contained a 20-times greater concentration of platelets before platelet activation and a 50-times greater concentration of PDGF-BB without formation of a fibrin gel after platelet activation than WB. Surprisingly, total PDGF-BB content in the PFC was twice that of activated WB, which suggested that a substantial portion of the PDGF-BB became trapped in the fibrin glue, and replacement of plasma with saline is crucial for maximization of platelet-derived factors. As an anticoagulant, ethylene di-amine tetra-acetic acid disodium inhibited platelet aggregation more efficiently than acid citrate dextrose solution, resulting in higher nonaggregated platelet yield and final PDGF-BB content. These results increase our understanding of how to optimize and standardize preparation of platelet-derived factors at maximum concentrations.
926. Polyfluoroheterocyclic compounds. Part V. Catalytic reduction of perfluoro- and chlorofluoro-pyridines and the preparation of polyfluoropyridinecarboxylic acids (1965)

R. D. Chambers, F. G. Drakesmith and W. K. R. Musgrave, J. Chem. Soc., 1965, 5045 DOI: 10.1039/JR9650005045
Digital-analogue phase shifter on the base of ferroelectric varactors (2003)

Results of theoretical investigation and experimental testing of 3-cascade S-band phase-shifter based on ferroelectric varactors with digital-analogue controlling are observed. The design advantages are discussed.
Multicenter Randomized Trial of a Comprehensive Hospital Discharge and Outpatient Heart Failure Management Program (2004)

This comprehensive hospital discharge and outpatient management program prolonged time to first event, reduced hospital readmissions, improved survival and quality of life of patients hospitalized for HF, while reducing cost of management.
An auto-ranging 50-210 Mb/s clock recovery circuit with a time-to-digital converter (2003)

This clock recovery circuit has auto-ranging. A time-to-digital converter (TDC) rather than a frequency detector is employed for accurate information about the cycle time of the incoming data. This auto-ranging circuit, which operates in the time domain, eliminates the inherent problems of harmonic locking found in conventional circuits. This circuit is configured as a triple-loop structure, which consists of a center frequency-tuning loop, a frequency detecting loop, and a phase detecting loop.
Degradation of albumin, haemopexin, haptoglobin and transferrin, by black-pigmented Bacteroides species (1984)

Strains of six black-pigmented Bacteroides species and one un-named strain were examined for their ability to degrade the plasma proteins albumin, haemopexin, haptoglobin and transferrin. Strains of B. gingivalis were most effective, degrading all four plasma proteins at different rates. Strains of B. intermedius and B. asaccharolyticus showed intermediate activities, degrading different individual plasma proteins; strains of B. melaninogenicus, B. loeschei and B. denticola were least active, degrading only haemopexin. These findings are discussed in relation to the availability in tissue fluids of iron for bacterial growth.
Über die Oxydationsprodukte von Thiocarbonsäureamiden, V. Oxydationsreaktionen an mehrfunktionellen Thioamidsystemen (1961)

Abstract Bei der Oxydation von Dicarbonsäuredithioamiden konnten Dicarbonsäure‐dithioamid‐bis‐ S ‐oxyde isoliert werden. In der Reihe der Alkylen‐bisthioamide wurden Vertreter der folgenden möglichen Typen erhalten: magnified image Die Sonderstellung des Malonsäuredithioamids, welches bei der Oxydation ein cyclisches Dithiyliumsalz liefert, findet sich in schwächerer Ausprägung auch bei den Alkylenbisthioamiden, in denen die beiden Thioamidgruppen nur durch eine CH 2 ‐Gruppe voneinander getrennt sind.
Ocular Melanoma (2003)

Evidence for comorbid OM and CM exists in patients with strong phenotypic expression of atypical nevi and conjunctival melanoma, although CDKN2A mutations have not been documented in patients with OM.
ChemInform Abstract: Synthesis and Biological Evaluation of New Antiinflammatory 1‐Benzothiophene‐2‐carboxanilides. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High performance multiwall carbon nanotube bolometers (2010)

High infrared bolometric photoresponse has been observed in multiwall carbon nanotube (MWCNT) films at room temperature. The observed detectivity D∗ in exceeding 3.3×106 cm Hz1/2/W on MWCNT film bolometers is a factor of 7 higher than that obtained on the single-wall CNT (SWCNT) counterparts. The response time of about 1–2 ms on MWCNT bolometers is more than an order of magnitude shorter than that of SWCNT bolometers. The observed high performance may be attributed to the naturally suspended inner-shell structure in a MWCNT, which enhances photon absorption and restricts bolometer external thermal link to environment.
Computer Methods for Circuit Analysis and Design (1983)

Computer methods for circuit analysis and design , Computer methods for circuit analysis and design , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Energy Consumption Optimization Scheme of Cloud Data Center Based on SDN (2018)

In response to the mobile Internet, Internet of things and cloud computing technology fast development, the operation of large-scale distributed computing cloud data center construction in the world at the same time, the network data calculation of energy consumption problem is causing extensive concern. And the software-defined Network (SDN) provides a feasible solution to the rigid problem of traditional Network architecture. Based on SDN technology, this paper proposes a method of energy consumption control based on cloud data center. Aiming at server energy saving, the multi-objective optimization model of virtual machine migration integration is established, and the integration mechanism of virtual machine migration based on mixed single-parent genetic algorithm is proposed. The experimental results show that the algorithm can be used to solve the problem of virtual machine migration and integration in data center.
Insulin-like growth factors prevent apoptosis in cortical neurons isolated from stroke-prone spontaneously hypertensive rats. (1997)

Cerebral ischemia induces a massive efflux of glutamate causing delayed neuronal death in stroke-prone spontaneously hypertensive rats (SHRSP) but not in Wistar Kyoto rats (WKY). It is obvious that L-N-nitroarginine (L-NNA; NO synthase (NOS) inhibitor), benzamide (poly(ADP-ribose) synthetase inhibitor), and growth factors are involved in reducing neuronal cell death due to toxic conditions, especially phosphatidylinositol 3 (PI3)-kinase activity; however, no studies have clarified whether genetic vulnerability to neurotoxic states is present in cortical neurons isolated from SHRSP. For this purpose, we prepared cortical neurons from WKY and SHRSP (15 weeks of gestation) to test the genetic vulnerability involved in the pathogenesis of stroke as well as apoptosis of cortical neurons isolated from SHRSP. We also examined the mechanisms necessary to reduce apoptosis under neurotoxic states using ultrastructural and biochemical techniques. Cortical neurons from SHRSP were in fact found to be more vulnerable than neurons from WKY and resulted in apoptosis when treated with nitric oxide (NO)- and N-methyl-D-aspartate (NMDA)-mediated neurotoxic agents. Growth factors, especially insulin-like growth factor (IGF), rescued neurons from NO- and NMDA-mediated neurotoxicity, particularly those from SHRSP. Conversely, benzamide and L-NNA reduced NMDA-mediated neurotoxicity but not NO-mediated toxicity. The ability to protect neurons from neurotoxicity was as follows: IGF-->nerve growth factor epidermal growth factor-->L-NNA-->benzamide. In addition, it was demonstrated that wortmannin, a PI3-kinase inhibitor, lessened the protective effects of these growth factors against NO-mediated toxicity. The data thus indicate that genetic factors related to neuronal vulnerability to apoptosis are involved in the pathogenesis of stroke lesions in SHRSP. PI3-kinase activity, which is stimulated by growth factors, is closely related to protective effects against NO- and NMDA-mediated toxicity in cortical neurons, especially those isolated from SHRSP. Moreover, the genetic vulnerability observed in SHRSP neurons is possibly linked to the inadequate activation of signaling pathways in the downstream of protein tyrosine kinases.
LED light sources for head-up displays (2005)

The concept of Head-Up Displays is simple: move the important information a driver needs to see up into their line of sight, so they don’t have to take their eyes off the road. A projected image appears to be floating freely over the hood, at a distance of approximately two meters. Mirrors direct light from an image-generating LCD to the windshield where it is superimposed with the driver’s field of view. The LCD is lit with an appropriate light source. Requirements like long lifetime, vibration resistance, thermal stability and high luminance make LED light sources ideal for use in the automotive industry. The paper discusses the principles of the optical system design of an LED light source for Head-Up Displays.
Docosahexaenoic Acid Improves the Nitroso-Redox Balance and Reduces VEGF-Mediated Angiogenic Signaling in Microvascular Endothelial Cells (2010)

DHA improves NO bioavailability, decreases O(2)(-) production, and blunts VEGF-mediated angiogenic signaling. These findings suggest a role for ω-3 PUFAs, particularly DHA, in maintaining vascular integrity while reducing pathologic retinal neovascularization.
Blind Image Quality Assessment Using Semi-supervised Rectifier Networks (2014)

It is often desirable to evaluate images quality with a perceptually relevant measure that does not require a reference image. Recent approaches to this problem use human provided quality scores with machine learning to learn a measure. The biggest hurdles to these efforts are: 1) the difficulty of generalizing across diverse types of distortions and 2) collecting the enormity of human scored training data that is needed to learn the measure. We present a new blind image quality measure that addresses these difficulties by learning a robust, nonlinear kernel regression function using a rectifier neural network. The method is pre-trained with unlabeled data and fine-tuned with labeled data. It generalizes across a large set of images and distortion types without the need for a large amount of labeled data. We evaluate our approach on two benchmark datasets and show that it not only outperforms the current state of the art in blind image quality estimation, but also outperforms the state of the art in non-blind measures. Furthermore, we show that our semi-supervised approach is robust to using varying amounts of labeled data.
Amino acid distributions around <i>O</i>-linked glycosylation sites (1991)

To study the sequence requirements for addition of O-linked N-acetylgalactosamine to proteins, amino acid distributions around 174 O-glycosylation sites were compared with distributions around non-glycosylated sites. In comparison with non-glycosylated serine and threonine residues, the most prominent feature in the vicinity of O-glycosylated sites is a significantly increased frequency of proline residues, especially at positions -1 and +3 relative to the glycosylated residues. Alanine, serine and threonine are also significantly increased. The high serine and threonine content of O-glycosylated regions is due to the presence of clusters of several closely spaced glycosylated hydroxy amino acids in many O-glycosylated proteins. Such clusters can be predicted from the primary sequence in some cases, but there is no apparent possibility of predicting isolated O-glycosylation sites from primary sequence data.
Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacological Effect of Orally Administered CORT125134: An Adaptive, Double‐Blind, Randomized, Placebo‐Controlled Phase 1 Clinical Study (2017)

CORT125134 is an orally active, high-affinity, selective antagonist of the glucocorticoid receptor that is being developed for indications that may benefit from the modulation of cortisol activity. This first-in-human study was conducted to evaluate the dose-related safety, tolerability, pharmacokinetics and pharmacological effects of CORT125134 and its active metabolite CORT125201. Eighty-one healthy male or female subjects received a single dose of 5 to 500 mg CORT125134 or matching placebo across 9 cohorts; 1 cohort received 150 mg CORT125134 after a high-fat breakfast; and 46 subjects received 50 to 500 mg CORT125134 or matching placebo once daily for up to 14 days across 4 cohorts. CORT125134 was well tolerated at doses up to 250 mg per day for 14 days. CORT125134 was absorbed rapidly and eliminated with a mean half-life ranging from 11 to 19 hours. Steady state was achieved by day 7. Exposure increased in a greater than proportional manner, particularly at lower doses. Exposure to CORT125201 at steady state was less than 5% that of parent CORT125134. Evidence for the desired pharmacological effect (glucocorticoid receptor antagonism) was demonstrated by the ability of CORT125134 to prevent several effects of the glucocorticoid receptor agonist prednisone.
The single dose pharmacokinetics and safety of deramciclane in healthy male volunteers (1999)

The pharmacokinetics and tolerability of a new putative non-benzodiazepine type anxiolytic compound deramciclane was studied in two consecutive studies. An open dose-escalation design was used to study doses from 0.2 to 50 mg in 18 healthy male volunteers. In the second study doses from 50 to 150 mg were investigated in 14 healthy males in a double-blind, placebo-controlled, dose escalation study. Deramciclane was rapidly absorbed from the GI-tract and T(max) was 2-4 h. The elimination half-life increased from about 20 h to about 32 h with the increasing dose. Nevertheless, the AUC(0-infinity) values increased linearly within the studies over the dose ranges of 3-50 and 50-150 mg. However, the increase was more than the ratio of the dose over the total dose range of 3-150 mg. Therefore, non-linear pharmacokinetics of deramciclane at high doses cannot be excluded. N-desmethyl deramciclane, which is the active metabolite of deramciclane, was determined in plasma. C(max) was reached at about 6 h. The AUC(0-48 h) for the N-desmethyl metabolite was about one third of the AUC(0-infinity) of the parent compound and the ratio remained constant at each dose level. Deramciclane was safe, and was well tolerated at each dose level.
Independence of brain and tympanic temperatures in an unanesthetized human (1988)

Temperature within the brain and the esophagus and at the tympanum were obtained in a 12-yr-old male in a series of experiments that began 8 days after surgery for implantation of a drainage catheter. Fanning the face did reduce tympanic temperature but not temperature in the brain; brain temperatures followed esophageal temperatures. In long-term monitoring, temperature in the lateral ventricle was 0.5 degree C above esophageal temperature and 0.2 degree C below that in white matter 1 cm above, with the offsets fixed throughout the overnight cycle. All temperatures went through similar excursions when the face was excluded from fanning applied to the body. These observations highlight the fact that in humans the defense against hyperthermia takes advantage of cooling distributed over the entire skin surface.
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice (1999)

The body growth of animals is regulated by growth hormone and IGF-I. The classical theory of this regulation is that most IGF-I in the blood originates in the liver and that body growth is controlled by the concentration of IGF-I in the blood. We have abolished IGF-I production in the livers of mice by using the Cre/loxP recombination system. These mice demonstrated complete inactivation of the IGF-I gene in the hepatocytes. Although the liver accounts for less than 5% of body mass, the concentration of IGF-I in the serum was reduced by 75%. This finding confirms that the liver is the principal source of IGF-I in the blood. However, the reduction in serum IGF-I concentration had no discernible effect on postnatal body growth. We conclude that postnatal body growth is preserved despite complete absence of IGF-I production by the hepatocytes.
Transformation Optics and the Geometry of Light (2008)

Metamaterials are beginning to transform optics and microwave technology thanks to their versatile properties that, in many cases, can be tailored according to practical needs and desires. Although metamaterials are surely not the answer to all engineering problems, they have inspired a series of significant technological developments and also some imaginative research, because they invite researchers and inventors to dream. Imagine there were no practical limits on the electromagnetic properties of materials. What is possible? And what is not? If there are no practical limits, what are the fundamental limits? Such questions inspire taking a fresh look at the foundations of optics and at connections between optics and other areas of physics. In this article we discuss such a connection, the relationship between optics and general relativity, or, expressed more precisely, between geometrical ideas normally applied in general relativity and the propagation of light, or electromagnetic waves in general, in materials. We also discuss how this connection is applied: in invisibility devices, perfect lenses, the optical Aharonov-Bohm effect of vortices and in analogues of the event horizon.
Mushroom-Type phase change memory with projection liner: An array-level demonstration of conductance drift and noise mitigation (2021)

Phase change memory (PCM) is rapidly emerging as a promising candidate for building non-von Neumann accelerators for deep neural networks (DNN) based on in-memory computing. However, conductance drift and noise are key challenges for the reliable storage of synaptic weights in such accelerators. We demonstrate, for the first time, conductance drift and noise mitigation by integrating a projection liner into multilevel mushroom-type PCM devices. While the projection liner has little effect on SET-state drift (crystalline phase), it substantially reduces drift for RESET states (amorphous phase) and improves the overall noise across SET and RESET states. Further improvement in drift is demonstrated by combining projection liner with a low-drift GeSbTe (GST) phase-change material variant. Lower drift and lower device-to-device drift variability for devices with projection liner are confirmed with large-scale experiments of over 1,000 devices. Moreover, we demonstrate using 10,000 projected PCM devices that tighter closed-loop programming distributions can be achieved, which is critical for in-memory computing based accelerators for applications such as DNN inference. Simulations show that the lower drift and device-to-device drift variability significantly increase the inference life span of PCM-based DNN accelerators.
Cooperative Tasks between Humans and Robots in Industrial Environments (2012)

Collaborative tasks between human operators and robotic manipulators can improve the performance and flexibility of industrial environments. Nevertheless, the safety of humans should always be guaranteed and the behaviour of the robots should be modified when a risk of collision may happen. This paper presents the research that the authors have performed in recent years in order to develop a human-robot interaction system which guarantees human safety by precisely tracking the complete body of the human and by activating safety strategies when the distance between them is too small. This paper not only summarizes the techniques which have been implemented in order to develop this system, but it also shows its application in three real human-robot interaction tasks.
The photonic perspective of organic light‐emitting transistors (2011)

Abstract This article will give an overview of the current state‐of‐the‐art of OLETs from the point of view of their photonic characteristics. In particular, the different device structures realized, the materials used and the strategies implemented to integrate optical resonators and waveguiding structures into light‐emitting field‐effect transistors will be reviewed and the main findings discussed. (Picture: Courtesy of E. T. C. srl)
<title>Monte Carlo and diffusion calculations of photon migration in noninfinite highly scattering media</title> (1991)

We have investigated the effect of an absorbing object on the time- course and the migration paths of photons within a highly scattering cylindrical phantom. Experimentally, we injected photons into the phantom at one point on the circumference, and recorded the time course of the photons arriving at various detection positions round the cylinder. The simulations used both a Monte-Carlo approach and a diffusion approach to calculate the photon migration. The two computational approaches are similar. The calculated time-course signals agree well with the experimentally observed signals. Moreover, we are able to use a diffusion approximation to calculate the probable paths taken for photons which take a defined time to travel from source to detector.