gebhart/patrepeval huggingface dataset:
Discordance of Databases Designed for Claims Payment versus Clinical Information Systems: Implications for Outcomes Research (1993)

Our results suggest that insurance claims data lack important diagnostic and prognostic information when compared with concurrently collected clinical data in the study of ischemic heart disease. Thus, insurance claims data are not as useful as clinical data for identifying clinically relevant patient groups and for adjusting for risk in outcome studies, such as analyses of hospital mortality.
Space-time processing for multichannel synthetic aperture radar (1999)

Synthetic aperture radar (SAR) provides high-resolution images of a non-moving ground scene, but fails to indicate the presence and position of moving objects. As in airborne MTI (moving-target indication) systems the solution to this problem is to use an array of antennas or subapertures and several receiving channels (`MSAR', or multichannel SAR), and to apply multichannel clutter suppression. One of the most efficient methods is adaptive space-time processing (STAP), which can be simplified to frequency-dependent spatial processing in the Doppler domain. Some of these techniques applied to SAR are reviewed and illustrated with data gathered by the German experimental multichannel SAR system `AER-II'.
Masking of the CBF1/RBPJ <sub>κ</sub> Transcriptional Repression Domain by Epstein-Barr Virus EBNA2 (1995)

Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) is a transcriptional activator that is essential for EBV-driven B cell immortalization. EBNA2 is targeted to responsive promoters through interaction with a cellular DNA binding protein, C promoter binding factor 1 (CBF1). A transcriptional repression domain has been identified within CBF1. This domain also interacts with EBNA2, and repression is masked by EBNA2 binding. Thus, EBNA2 acts by countering transcriptional repression. Mutation at amino acid 233 of CBF1 abolishes repression and correlates with a loss-of-function mutation in the Drosophila homolog Su(H).
Production of Bio-Hydrogenated Diesel by Hydrotreatment of High-Acid-Value Waste Cooking Oil over Ruthenium Catalyst Supported on Al-Polyoxocation-Pillared Montmorillonite (2012)

Waste cooking oil with a high-acid-value (28.7 mg-KOH/g-oil) was converted to bio-hydrogenated diesel by a hydrotreatment process over supported Ru catalysts. The standard reaction temperature, H2 pressure, liquid hourly space velocity (LHSV), and H2/oil ratio were 350 °C, 2 MPa, 15.2 h–1, and 400 mL/mL, respectively. Both the free fatty acids and the triglycerides in the waste cooking oil were deoxygenated at the same time to form hydrocarbons in the hydrotreatment process. The predominant liquid hydrocarbon products (98.9 wt%) were n-C18H38, n-C17H36, n-C16H34, and n-C15H32 when a Ru/SiO2 catalyst was used. These long chain normal hydrocarbons had high melting points and gave the liquid hydrocarbon product over Ru/SiO2 a high pour point of 20 °C. Ru/H-Y was not suitable for producing diesel from waste cooking oil because it formed a large amount of C5–C10 gasoline-ranged paraffins on the strong acid sites of HY. When Al-polyoxocation-pillared montmorillonite (Al13-Mont) was used as a support for the Ru catalyst, the pour point of the liquid hydrocarbon product decreased to −15 °C with the conversion of a significant amount of C15–C18 n-paraffins to iso-paraffins and light paraffins on the weak acid sites of Al13-Mont. The liquid product over Ru/Al13-Mont can be expected to give a green diesel for current diesel engines because its chemical composition and physical properties are similar to those of commercial petro-diesel. A relatively large amount of H2 was consumed in the hydrogenation of unsaturated C=C bonds and the deoxygenation of C=O bonds in the hydrotreatment process. A sulfided Ni-Mo/Al13-Mont catalyst also produced bio-hydrogenated diesel by the hydrotreatment process but it showed slow deactivation during the reaction due to loss of sulfur. In contrast, Ru/Al13-Mont did not show catalyst deactivation in the hydrotreatment of waste cooking oil after 72 h on-stream because the waste cooking oil was not found to contain sulfur-containing compounds.
Detection of plasma levels of Apelin12,NT-proBNP and cardiac function in patients with chronic heart failure (2009)

Objective To investigate the relation among plasma levels of Apelin 12,NT-proBNP and cardiac function in patients with chronic heart failure.Methods General informations of having been selected 72 cases of CHF patients and 20 healthy controls were collected on the study and collection of their peripheral blood early morning on an empty stomach,the plasma Apelin12 and NT-proBNP concentration of 72 patients with CHF and 20 healthy controls were measured dividedly by enzyme-linked immunosorbent assay(ELASA)and radioimmunology,and carried out analysis of the comparative study.Results The plasma levels of Apelin12 were significantly higher than those of the healthy controls according to NYHA Ⅰ-Ⅱ(P＜0.05),and lower than those of the healthy controls according to NYHA Ⅲ-Ⅳ(P＜0.05).The plasma levels of NT-proBNP were significantly higher than those of the healthy controls according to NYHA functional classification(linear correlation test:X2=13.306,P=0.039);multi-factor logistic regression analysis found that Apelin12 had a positive correlation with waist circumference and the ejection fraction,and had a negative correlation with LVIDd and the blood pressure(P＜0.05).Conclusions The plasma levels of Apelinl 2 and NT-proBNP with CHF patients changed with cardiac functional classification,may join the occurrence and development of the pathophysiological processes of heart failure together.

Key words: 
Heart failure; Apelin12; NT-proBNP
Parameter Synthesis of Coupled Nonlinear Oscillators for CPG-Based Robotic Locomotion (2014)

This paper presents a numerical method for parameter synthesis of a central pattern generator (CPG) network to acquire desired locomotor patterns. The CPG network is modeled as a chain of unidirectionally or bidirectionally coupled Hopf oscillators with a novel coupling scheme that eliminates the influence of afferent signals on amplitude of the oscillator. The method converts the related CPG parameters into dynamic systems that evolve as part of the CPG network dynamics. The frequency, amplitude, and phase relations of teaching signals can be encoded by the CPG network with the proposed learning rules. The ability of the method to learn instructed locomotor pattern is proven with simulations. Application of the proposed method to online gait synthesis of a robotic fish is also presented.
Gene Discovery through Expressed Sequence Tag Sequencing in<i>Trypanosoma cruzi</i> (1998)

Analysis of expressed sequence tags (ESTs) constitutes a useful approach for gene identification that, in the case of human pathogens, might result in the identification of new targets for chemotherapy and vaccine development. As part of the Trypanosoma cruzi genome project, we have partially sequenced the 5' ends of 1, 949 clones to generate ESTs. The clones were randomly selected from a normalized CL Brener epimastigote cDNA library. A total of 14.6% of the clones were homologous to previously identified T. cruzi genes, while 18.4% had significant matches to genes from other organisms in the database. A total of 67% of the ESTs had no matches in the database, and thus, some of them might be T. cruzi-specific genes. Functional groups of those sequences with matches in the database were constructed according to their putative biological functions. The two largest categories were protein synthesis (23.3%) and cell surface molecules (10.8%). The information reported in this paper should be useful for researchers in the field to analyze genes and proteins of their own interest.
Mathematical structures for computer science (1982)

From the Publisher:
Designed for computer science majors, Mathematical Structures for Computer Science offers a pedagogically rich and intuitive introduction to discrete mathematical structures. The book is both accessible and comprehensive, and the first three editions have been very popular among students and professors for over 16 years.

Text balances clear presentation of the concepts with applications relevant to the future computer scientist Focuses exclusively on the mathematical needs of the computer science major Coverage geared specifically for intro-level, one-term course
Somatostatin Analog: Plasma Catecholamine Suppression Mediated by the Central Nervous System* (1980)

The somatostatin analog, des-AA1,2,4,5,12,13-[D-Trp8]somatostatin (ODT8-SS), acts within the central nervous system to suppress the rise in plasma catecholamines associated with a variety of neural stimuli. Insulin-induced hypoglycemia or stress caused significant elevations in plasma catecholamines that were abolished by intracerebroventricular (icv) administration of ODT8-SS. Bombesin, carbachol, or 2-deoxyglucose, injected icv, evoked marked elevations in plasma epinephrine and norepineprine. These effects were also prevented by ODT8-SS given icv. In all experiments, ODT8-SS appeared to be more effective in lowering plasma epinephrine than in lowering plasma norepinephrine. Systemic administration of ODT8-SS was ineffective in lowering plasma catecholamine levels. Native somatostatin given icv produced inconsistent effects on plasma catecholamine levels. These data suggest that the somatostatin analog, ODT8-SS, acts within the central nervous system to modulate sympathetic nervous system activity. It is suggested, but not established, that this analog acts through the same receptor as native somatostatin.
<title>Novel surface-plasmon-resonance-based fiber optic sensor applied to biochemical sensing</title> (1993)

A fiber optic chemical sensor is presented which utilizes surface plasmon resonance excitation. The sensor is advantageous since it eliminates the traditional bulk optic prism in favor of a relatively simple and inexpensive design. This configuration allows for remote sensing and multiplexing. The sensing element of the multi-mode fiber optic has been fabricated by removing a section of the fiber cladding and symmetrically depositing a thin layer of highly reflecting metal directly onto the fiber core. A white light source is used to introduce a range of optical wavelengths into the optical fiber. A fiber optic spectrograph is used at the output of the fiber optic sensor to measure the transmitted spectral intensity distribution (light intensity versus wavelength). There are two sensor configurations presented. The system should find general utility as a dip-probe for quantification of proteins in solution.
Nonnegative matrix partial co-factorization for drum source separation (2010)

We address a problem of separating drums from polyphonic music containing various pitched instruments as well as drums. Nonnegative matrix factorization (NMF) was successfully applied to spectrograms of music to learn basis vectors, followed by support vector machine (SVM) to classify basis vectors into ones associated with drums (rhythmic source) only and pitched instruments (harmonic sources). Basis vectors associated with pitched instruments are used to reconstruct drum-eliminated music. However, it is cumbersome to construct a training set for pitched instruments since various instruments are involved. In this paper, we propose a method which only incorporates prior knowledge on drums, not requiring such training sets of pitched instruments. To this end, we present nonnegative matrix partial co-factorization (NMPCF) where the target matrix (spectrograms of music) and drum-only-matrix (collected from various drums a priori) are simultaneously decomposed, sharing some factor matrix partially, to force some portion of basis vectors to be associated with drums only. We develop a simple multiplicative algorithm for NMPCF and show its usefulness empirically, with numerical experiments on real-world music signals.
Oxygen-Promoted Palladium(II) Catalysis:  Facile C(sp<sup>2</sup>)−C(sp<sup>2</sup>) Bond Formation via Cross-Coupling of Alkenylboronic Compounds and Olefins (2004)

[reaction: see text] Oxygen-promoted Pd(II) catalysis facilitated the synthesis of conjugated dienes by cross-coupling of alkenylboronic compounds and various olefins including highly substituted alkenes and cyclohexenone. Under mild conditions, these versatile reactions were efficient and highly stereoselective.
Characterization of Raman Spectra Measured <i>in Vivo</i> for the Detection of Cervical Dysplasia (2007)

Raman spectroscopy has been shown to have the potential for providing differential diagnosis in the cervix with high sensitivity and specificity in previous studies. The research presented here further evaluates the potential of near-infrared Raman spectroscopy to detect cervical dysplasia in a clinical setting. Using a portable system, Raman spectra were collected from the cervix of 79 patients using clinically feasible integration times (5 seconds on most patients). Multiple Raman measurements were taken from colposcopically normal and abnormal areas prior to the excision of tissue. Data were processed to extract Raman spectra from measured signal, which includes fluorescence and noise. The resulting spectra were correlated with the corresponding histopathologic diagnosis to determine empirical differences between different diagnostic categories. Using histology as the gold standard, logistic regression discrimination algorithms were developed to distinguish between normal ectocervix, squamous metaplasia, and high-grade dysplasia using independent training and validation sets of data. An unbiased estimate of the accuracy of the model indicates that Raman spectroscopy can distinguish between high-grade dysplasia and benign tissue with sensitivity of 89% and specificity of 81%, while colposcopy in expert hands was able to discriminate with a sensitivity and specificity of 87% and 72%.
Amplification and Cloning of Near Full-Length HIV-2 Genomes (2005)

The genomes of human immunodeficiency virus type 2 (HIV-2), like those of HIV-1, are not only extremely variable but are also highly recombinogenic. Determination of subtypes based on partial genomes cannot predict the subtype classification of other regions of the genome owing to the frequent occurrence of recombinant genomes among subtypes. To fully understand the genetic variation and evolution of HIV-2s, full-length viral genomes need to be obtained for genetic analysis. Full-length HIV-2 genomes can also be used as infectious clones to study viral biological characteristics and as reference sequences for phylogenetic analysis. More important, all genes in the obtained genomes can be cloned into expression vectors to produce proteins that can be used as antigens for diagnostic reagents or as immunogens for vaccine development. The long-range polymerase chain reaction technique has recently become a more preferred method than the lambda phage cloning method to obtain near-full-length HIV-2 genomes.
Inhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three‐dimensional lung cancer xenograft model (2010)

: Engineered A549 lung tumors can be created by 3D encapsulation in an ECM substitute with user controlled composition. The engineered tumors regress and lose vascularity in response to a dual activity inhibitor of the LPA signaling pathway. Cancer 2010. (c) 2010 American Cancer Society.
[Comparison on the performance of both temporal and temporal-spatial models for outbreak detection through China Infectious Diseases Automated-alert and Response System (CIDARS)]. (2011)

Comparing to the temporal model, the temporal-spatial model of CIDARS seemed to be better performed on outbreak detection.
Identifying Reflected Images From Object Detector in Indoor Environment Utilizing Depth Information (2020)

We observed that mirror reflection severely degrades person detection performance in an indoor environment, which is an essential task for service robots. To address this problem, we propose a new real-time method to identify reflected virtual images in an indoor environment utilizing 3D depth information. Images reflected by the mirror are similar to real objects, so it is a non-trivial task to differentiate them. Conventional object detectors, which do not deal with this problem, obviously recognize reflected images as real objects. The proposed method compares the geometric relationship between the 3D spatial information of the detected object and its surrounding environment where the object locates. It analyzes the layout of surrounding indoor space utilizing semantic segmentation and plane detection method. With the estimated layout of indoor space, detected object candidates are examined whether they are real or reflected images utilizing 3D depth information. To verify the proposed method, a large indoor dataset was newly acquired and examined in a dedicated <bold xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"/> <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Living-lab</i> <bold xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"/> environment. The performance of the algorithm is verified by comparing conventional detectors with the proposed method in the acquired <bold xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"/> <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Living-lab dataset</i> <bold xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"/> .
Computer Simulation Predicting Temperature Distributions Generated by Microwave Absorption in Multilayered iedia (1984)

A numerical procedure to calculate the time dependence of temperature profiles in multi-layered plane media is described. Discretization of the continuous problem is accomplished by dividing each layer into a number of sublayers. A semi-discrete finite difference method is used to express the temperatures of the sublayers in closed form as a function of the microwave input. Applying the method in an iterative way allows treatment of the non-linear case, which arises when material permittivity is temperature dependent. Numerical results are given to illustrate the versatility of the developed computer program. The simulations are verified experimentally by use of a data acquisition system and a good agreement was found.
Hombre de genio y de ingenio (2007)

espanolCon ocasion de la jubilacion como profesor de la Universite de Provence I, se ofrece un breve homenaje a Benito Pelegrin en forma de comentario de sus trabajos. Se analizan sus tesis interpretativas y la influencia de las mismas. Se revisa su labor como escritor, editor y traductor de las obras de Baltasar Gracian. EnglishOn the occasion of his retirement as a teacher at the Universite de Provence I, a brief homage (in the shape of commentary of his works) is paid to Benito Pelegrin. His interpretive theses and their influence are analyzed. His work as a writer, an editor and a translator of Baltasar Gracian's works is revised. francaisA l'occasion de la retraite comme professeur de l'Universite de Provence I, nous consacrons un bref hommage a Benito Pelegrin sous la forme d'un commentaire relatif a l'ensemble de ses travaux. Ses theses interpretatives et leur influence sont analysees. Sont ainsi etudies les travaux de l'ecrivain, de l'editeur et du traducteur des oeuvres de Baltasar Gracian.
Implementation guidelines for a real-time fault location system in electrical power networks (2016)

This paper presents constraints involved in the microelectronic implementation of a transmission line model based on transconductor-capacitor (gm-C) topologies. The presented line model, based on the discretization of a transmission line into a finite number of series inductors and shunt capacitors, is aimed for the fault location in power network, a technique using the Electromagnetic Time-Reversal (EMTR) principle. The discrete LC line behavior is simulated by gm-C circuits, more suitable for integration. This research exposes design limitations in term of transconductor non-linearities, finite common mode voltage amplification and offset, and shows how they impact the line model and the fault location method accuracy. According to the analysis, corresponding design constraints on the gm-C line model are deduced in order to reach a fault location resolution of 1%, while preserving a short processing time, inherent to the method, in comparison to classical methods.
Recent advances in B-cell epitope prediction methods (2010)

Identification of epitopes that invoke strong responses from B-cells is one of the key steps in designing effective vaccines against pathogens. Because experimental determination of epitopes is expensive in terms of cost, time, and effort involved, there is an urgent need for computational methods for reliable identification of B-cell epitopes. Although several computational tools for predicting B-cell epitopes have become available in recent years, the predictive performance of existing tools remains far from ideal. We review recent advances in computational methods for B-cell epitope prediction, identify some gaps in the current state of the art, and outline some promising directions for improving the reliability of such methods.
New CBC Vidicon-Telecine Operating Standards: With Particular Reference to the Gray-Scale Characteristic (1964)

The results presented are from an investigation to obtain optimum picture quality in 16mm vidicon-telecine installations of the Canadian Broadcasting Corp. Picture quality is examined in terms of signal-to-noise ratio, resolution, gray-scale rendition and lag. As a consequence to the investigation, new standard values of the vidicon peak-white signal current, aperture correction and gray-scale correction are about to be introduced into CBC operations. — The telecine gray-scale characteristic is plotted together with a typical 16mm print-through characteristic. The resultant curve is shown to be similar to that of the image-orthicon camera. The measurement of the gray-scale characteristic, using the Holmes-CBC slide, is shown to be distorted by shading errors, and a new slide is introduced to minimize this problem.
A 4-MB on-chip L2 cache for a 90-nm 1.6-GHz 64-bit microprocessor (2005)

A 4-MB L2 data cache was implemented for a 64-bit 1.6-GHz SPARC(r) RISC microprocessor. Static sense amplifiers were used in the SRAM arrays and for global data repeaters, resulting in robust and flexible timing operation. Elimination of the global clock grid over the SRAM array saves power, enabled by combining the clock information with array select signals. Redundancy was implemented flexibly, with shift circuits outside the main data array for area efficiency. The chip integrates 315 million transistors and uses an 8-metal-layer 90-nm CMOS process.
ER Dysfunction and Protein Folding Stress in ALS (2013)

Amyotrophic lateral sclerosis (ALS) is the most frequent paralytic disease in adults. Most ALS cases are considered sporadic with no clear genetic component. The disruption of protein homeostasis due to chronic stress responses at the endoplasmic reticulum (ER) and the accumulation of abnormal protein inclusions are extensively described in ALS mouse models and patient-derived tissue. Recent studies using pharmacological and genetic manipulation of the unfolded protein response (UPR), an adaptive reaction against ER stress, have demonstrated a complex involvement of the pathway in experimental models of ALS. In addition, quantitative changes in ER stress-responsive chaperones in body fluids have been proposed as possible biomarkers to monitor the disease progression. Here we review most recent advances attributing a causal role of ER stress in ALS.