gebhart/patrepeval huggingface dataset:
A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: a California Cancer Consortium study (2009)

Prostate cancer cells undergo neuroendocrine differentiation during androgen deprivation and secrete neuropeptides, hence activating androgen receptor-regulated genes. Src-family protein kinases are involved in neuropeptide-induced prostate cancer growth and migration. A phase II trial of AZD0530, an oral Src-family kinase inhibitor, in patients with advanced castration resistant prostate cancer was conducted. The primary endpoint was prostate cancer-specific antigen (PSA) response rate, defined as a 30% or greater decrease. A two-stage Simon design was used. Eligibility criteria included documentation of castration resistance (including antiandrogen withdrawal), adequate end-organ function, and performance status, and not more than one prior taxane-based chemotherapy regimen. AZD0530 was given at 175 mg orally once daily continuously. Rapid accrual led to 28 patients registering in the first stage. Median age was 67 years. Sixteen patients had performance status (PS) 0, eight patients had PS 1, and four patients had PS 2. Nine patients (32%) had prior docetaxel-based chemotherapy. Five patients had transient PSA reductions not meeting PSA response criteria. Median progression-free survival time was 8 weeks. Treatment was generally well tolerated. AZD0530, a potent oral Src kinase inhibitor, is feasible and tolerable in this pretreated patient population but possessed little clinical efficacy as monotherapy. Strong preclinical evidence warrants further investigation of AZD0530 in earlier-stage prostate cancer or as combination therapy.
Chemistry of Weathering and Protection (1984)

Wood exposed to the outdoors undergoes photodegradation and photooxidative degradation in the natural weathering process. UV light interacts with lignin to initiate discoloration and deterioration. Deterioration of wood in the natural weathering process involves a very complex, free radical reaction sequence. Light does not penetrate wood past 200 μm; therefore, degradation reactions are a surface phenomenon. The free radicals generated in wood by light rapidly interact with oxygen to produce hydroperoxides which in turn are easily decomposed to produce chromophoric groups. In this chapter the influence of outdoor weathering on the performance of wood and wood-based materials is discussed in detail. Macroscopic, microscopic, chemical, and physical changes are described. The mechanisms of weathering and methods of protection of exposed wood surfaces are summarized.
THE INFLUENCE OF TRANSMISSION TORQUES ON THE STEADY STATE HANDLING OF ALL WHEEL DRIVE VEHICLES HAVING ONE TRANSVERSE DIFFERENTIAL (1983)

It is common practice in light armoured military vehicles to use a transmission system having a single differential with front and rear wheels on each side solidly coupled together. This results in lateral and longitudinal traction transfer which influences the handling characteristics. A computer simulation of the steady state handling of vehicles of this type has been developed using data for light truck tyres. It predicts strong understeer behaviour under most conditions but suggests that in rear heavy trim the vehicle tends to oversteer when travelling downhill, and when descending steep wet gradients terminal oversteer can occur at relatively low lateral accelerations.
Quantitation of plasma apolipoprotein A-I using two monoclonal antibodies in an enzyme-linked immunosorbent assay. (1988)

A rapid sandwich enzyme-linked immunosorbent assay (ELISA) for the quantitation of human apolipoprotein (apo) A-I was developed. The assay uses a pair of noncompeting purified monoclonal antibodies to detect apoA-I in plasma. The antibodies used in this assay were selected because they bind greater than 90% of radioiodinated high density lipoprotein (HDL), they identify "fresh" nondeamidated epitopes on apoA-I, and they have comparable binding affinities for isolated HDL and HDL in plasma. The assay was standardized with a plasma secondary standard composed of lyophilized human serum. The assay was used to measure the apoA-I levels in normal subjects, patients with coronary artery disease, and patients with familial hypercholesterolemia. The results indicate that certain monoclonal antibodies can be used to reliably measure plasma levels of apoA-I in diverse groups of subjects.
Optimizing Breast-Pocket Irrigation: The Post-Betadine Era (2001)

The practice of breast-pocket irrigation with various antibiotic solutions is supported by good literature and extensive clinical practice among most plastic surgeons. Unfortunately, recent restrictions on the use of Betadine (povidone-iodine) for breast-pocket irrigation have left many plastic surgeons confused regarding their surgical protocol for aesthetic and reconstructive breast surgery. The purpose of this study was to examine the in vitro efficacy of alternative non-Betadine-containing solutions for breast-pocket irrigation and to subsequently provide recommendations for breast-pocket irrigation in the “post-Betadine era.” Bacitracin, cefazolin, gentamicin, and vancomycin were tested as single agents and in combination against organisms that have been most commonly cultured around breast implants and implicated in capsular contracture and peri-procedural infection. An established in vitro method was used for this testing. The single antibiotic agents were ineffective at controlling many of the bacteria tested. The combinations of bacitracin, cefazolin, and gentamicin, and vancomycin, cefazolin, and gentamicin both demonstrated excellent control of all the bacteria, except for allowing a 9 percent and a 6 percent growth of Pseudomonas, respectively. It was concluded that a combination breast irrigant of bacitracin, cefazolin, and gentamicin is an effective alternative to Betadine-containing breast irrigants and is recommended for clinical practice. Clinical implications are discussed in greater detail in the study. (Plast. Reconstr. Surg. 107: 1596, 2001.)
Joint inversion of Rayleigh and guided waves in high‐resolution seismic data using a genetic algorithm (1998)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1998Joint inversion of Rayleigh and guided waves in high‐resolution seismic data using a genetic algorithmAuthors: Michael RothKlaus HolligerMichael RothSwiss Federal Institute of Technology (ETH), Zurich, Switzerland and Klaus HolligerSwiss Federal Institute of Technology (ETH), Zurich, Switzerlandhttps://doi.org/10.1190/1.1820216 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1820216FiguresReferencesRelatedDetailsCited byA unified description of surface waves and guided waves with relative amplitude dispersion maps16 August 2021 | Geophysical Journal International, Vol. 227, No. 3Nonlinear inversion of potential-field data using a hybrid-encoding genetic algorithmComputers & Geosciences, Vol. 32, No. 2A Hybrid‐Ncoding Genetic Algorithm for Inversion of Potential‐Field Data31 May 2013 | Chinese Journal of Geophysics, Vol. 47, No. 1 SEG Technical Program Expanded Abstracts 1998ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1998 Pages: 2092 publication data© 1998 Copyright © 1998 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 06 Jan 2005 CITATION INFORMATION Michael Roth and Klaus Holliger, (1998), "Joint inversion of Rayleigh and guided waves in high‐resolution seismic data using a genetic algorithm," SEG Technical Program Expanded Abstracts : 1570-1573. https://doi.org/10.1190/1.1820216 Plain-Language Summary PDF DownloadLoading ...
Factors influencing the application of bacterial leaching to a Canadian uranium ore (1966)

Laboratory tests were conducted to investigate the effects of particle size and composition of the leaching solution on the extraction of uranium from an Elliot Lake ore in the presence of bacteria. It was shown that the leaching of particles coarser than 4 mesh in the presence of the Ferrobacillus-Thiobacillus group of bacteria was a very slow process, with only 70% of the uranium being extracted in thirty-two weeks. Uranium extractions of 90% were obtained when leaching particles finer than 4 mesh, in periods ranging from five to twenty weeks. The work showed that for ores coarser than 8 mesh it was necessary to add initially to the leach solution 1.0 g Fe/ 1 and nutrient salts containing nitrogen, phosphorus and potassium. Extraction rate of uranium increased with initial iron concentrations of up to 1.0 g Fe+41 1. The addition of iron and nutrient was not required for ores finer than 8 mesh. The work also indicated that the extraction rate is determined by the rate at which the leaching solutions can penetrate the particles to depth. Further tests showed that bacterial leaching could be used to recover most of the uranium from reject mill products such as flotation tailings. Mineralogical studies were done to determine how bacterial leaching affected the minerals present in the Elliot Lake ore.
Fluorescent Light-Up Detection of Amine Vapors Based on Aggregation-Induced Emission (2015)

Amines play vital roles in agricultural, pharmaceutical, and food industries, but volatile amine vapors are serious threats to human health. Previously reported fluorescent sensors for amine vapor detection usually suffer from aggregation-caused quenching (ACQ) effect and need to be dispersed in solution or matrix materials. Herein, based on the fluorogen of 2-(2-hydroxyphenyl)quinazolin-4(3H)-one (HPQ) with aggregation-induced emission (AIE) properties, we have developed a fluorescent sensor HPQ-Ac for light-up detection of amine vapors through aminolysis reaction. The portable HPQ-Ac sensor can be easily prepared by directly depositing on filter paper, and it can only light up via exposure to amine vapors among various volatile organic compounds. Taking advantage of its portability and high sensitivity for amine vapors, HPQ-Ac sensor can also be used for food spoilage detection and fluorescent invisible ink.
The Effects of Bicarbonate on Blood Coagulation (1980)

The anticoagulant effects of sodium and potassium bicarbonate were investigated with use of fresh human whole blood obtained from normal healthy volunteers. Results from prothrombin and thrombin clotting time determinations demonstrated that bicarbonate can interfere with the clotting process. Clinical data obtained from patients who received intravenous administration of sodium bicarbonate supported these findings.
Electron Exchange Involving a Sulfur-Stabilized Ruthenium Radical Cation (2007)

Half-sandwich Ru(II) amine, thiol, and thiolate complexes were prepared and characterized by X-ray crystallography. The thiol and amine complexes react slowly with acetonitrile to give free thiol or amine and the acetonitrile complex. With the thiol complex, the reaction is dissociative. The thiolate complex has been oxidized to its Ru(III) radical cation and the solution EPR spectrum of that radical cation recorded. Cobaltocene reduces the thiol complex to the thiolate complex. The 1H and 31P NMR signals of the thiolate complex in acetonitrile become very broad whenever the thiolate and thiol complexes are present simultaneously. The line broadening is primarily due to electron exchange between the thiolate complex and its radical cation; the latter is generated by an unfavorable redox equilibrium between the thiol and thiolate complexes. Pyramidal inversion of sulfur in the thiol complex is fast at room temperature but slow at lower temperatures; major and minor conformers of the thiol complex were observed by 31P NMR at -98 degrees C in CD2Cl2.
A dynamic and efficient representation of building-block layout (1987)

Dynamic layout representation is a key problem in developing a building block layout system. We have unified topological and geometrical representations, and developed efficient methods to update topological information after geometrical operations. The experimental results are very promising. This representation is the key for information flow in BEAR — a new building block layout system being developed at U. C. Berkeley.
A method for designing the variable-way high-power cavity combiner (2016)

The cavity combiner was put forward for high power combining due to its advantages of larger combining ability, variable input ways and less power loss. For the high power cavity combiner, it is better to keep the power loss ratio in a reasonable range, because much power loss would lead to strict requirements on cooling system. The combiner with variable input ways is convenient for outputting different powers according to practical demands. In this paper, a method for designing a variable-way high-power cavity combiner was proposed, based on the relation between input and output coupling coefficients obtained by analyzing the equivalent circuit of the cavity combiner. The method can make the designed cavity combiner in a matching state and its power loss rate in a reasonable range as the number of input ways changes. As an illustrating example, a cavity combiner with 500 MHz and variable input ways from 16 to 64 is designed, and the simulation results show that our proposed method is feasible.
ColorNet: Investigating the importance of color spaces for image classification (2019)

Image classification is a fundamental application in computer vision. Recently, deeper networks and highly connected networks have shown state of the art performance for image classification tasks. Most datasets these days consist of a finite number of color images. These color images are taken as input in the form of RGB images and classification is done without modifying them. We explore the importance of color spaces and show that color spaces (essentially transformations of original RGB images) can significantly affect classification accuracy. Further, we show that certain classes of images are better represented in particular color spaces and for a dataset with a highly varying number of classes such as CIFAR and Imagenet, using a model that considers multiple color spaces within the same model gives excellent levels of accuracy. Also, we show that such a model, where the input is preprocessed into multiple color spaces simultaneously, needs far fewer parameters to obtain high accuracy for classification. For example, our model with 1.75M parameters significantly outperforms DenseNet 100-12 that has 12M parameters and gives results comparable to Densenet-BC-190-40 that has 25.6M parameters for classification of four competitive image classification datasets namely: CIFAR-10, CIFAR-100, SVHN and Imagenet. Our model essentially takes an RGB image as input, simultaneously converts the image into 7 different color spaces and uses these as inputs to individual densenets. We use small and wide densenets to reduce computation overhead and number of hyperparameters required. We obtain significant improvement on current state of the art results on these datasets as well.
Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses (2001)

Ron receptor activation induces numerous cellular responses in vitro, including proliferation, dissociation, and migration. Ron is thought to be involved in blood cell development in vivo, as well as in many aspects of the immune response including macrophage activation, antigen presentation, and nitric oxide regulation. In previous studies to determine the function of Ron in vivo, mice were generated with a targeted deletion of the extracellular and transmembrane regions of this gene. Mice homologous for this deletion appear to die early during embryonic development. To ascertain the in vivo function of Ron in more detail, we have generated mice with a germline ablation of the tyrosine kinase domain. Strikingly, our studies indicate that this domain of Ron, and therefore Ron cytoplasmic signaling, is not essential for embryonic development. While mice deficient in this domain are overtly normal, mice lacking Ron signaling have an altered ability to regulate nitric oxide levels and, in addition, have enhanced tissue damage following acute and cell-mediated inflammatory responses.
Lattice Indexing for Spoken Term Detection (2011)

This paper considers the problem of constructing an efficient inverted index for the spoken term detection (STD) task. More specifically, we construct a deterministic weighted finite-state transducer storing soft-hits in the form of (utterance ID, start time, end time, posterior score) quadruplets. We propose a generalized factor transducer structure which retains the time information necessary for performing STD. The required information is embedded into the path weights of the factor transducer without disrupting the inherent optimality. We also describe how to index all substrings seen in a collection of raw automatic speech recognition lattices using the proposed structure. Our STD indexing/search implementation is built upon the OpenFst Library and is designed to scale well to large problems. Experiments on Turkish and English data sets corroborate our claims.
Spatially direct and indirect optical transitions in shallow etched GaAs/AlGaAs wires, dots and antidots (1993)

By applying a shallow etching technique, the electrons in a remote doped GaAs/AlGaAs quantum well and the photogenerated holes are separated into adjacent lateral regions. The dominant photoluminescence of these carriers is shown to be indirect in real space. In addition, a spatially direct luminescence is observed. Its origin depends on the type of structuring and is discussed for wires, dots and antidots in comparison with unstructured samples.
Molecular biology of the capsular genes of Streptococcus pneumoniae (2006)

The polysaccharide capsule of Streptococcus pneumoniae is the main virulence factor of this microorganism. Although the study of the genes responsible for the synthesis of the pneumococcal capsule enabled genetic and molecular analysis, the precise structure, organization, and functioning of these genes have only been investigated very recently. The genes implicated in the production of the type 3 capsule have been sequenced, expressed and their corresponding products biochemically characterized. In addition, partial information on the genes responsible for the biosynthesis of the capsules of pneumococcal types 1, 14 or 19 F is currently available.
A grouping algorithm of helpers in peer-to-peer video-on-demand systems (2010)

Peer-to-peer (P2P) content distribution effectively solves the problem of large-scale streaming media delivery. But the performance of a P2P system is primarily bottlenecked, because the upload bandwidth of the participating peers is limited. Using helpers in the P2P system utilizes upload bandwidth of those idle peers uninterested in the delivered content, which further improves the performance of P2P systems, and the feasibility and validity have been testified [1]. Aiming at the p2p video-on-demand system, this thesis designs a novel grouping algorithm of helpers. In order to make more rational and effective use of helpers, the algorithm divides the helpers into different groups according to the number of each video's users, thus reducing the average view delay of whole system and improving the utilization rate of the helpers, reinforcing watch experience for users of the system. Analysis and simulation results corroborate the effectiveness of the proposed algorithm in the paper.
Segmenting Financial Services Markets for Customer Relationships: A Portfolio-Based Approach (1998)

(1998). Segmenting Financial Services Markets for Customer Relationships: A Portfolio-Based Approach. The Service Industries Journal: Vol. 18, No. 3, pp. 38-54.
Correlation between structure characteristics and adsorption properties of regenerated cellulose fibers (2002)

We correlate fine structure with the adsorption behavior of new (lyocell) and conventional (viscose, modal) regenerated cellulose fibers. We have studied the molecular structure, the fine structure and, most important of all, the amorphous regions and voids in the system. Differences in adsorption properties of all three-fiber types were determined by using several methods for quantification of water, dye and iodine adsorption. The structural analysis shows that higher molecular weight, a higher degree of crystallinity and a higher molecular orientation are found in lyocell fibers [1]. Our results obtained by several independent methods demonstrate clearly that the adsorption properties of cellulose fibers depend, with the exception of the portion and orientation of amorphous regions, predominantly on the void system (diameter, volume and inner surface of voids) [2].
Highly sensitive detection of ALK resistance mutations in plasma using droplet digital PCR (2018)

The protocol for ddPCR-based liquid biopsy has a feasibility for the screening of secondary ALK-TKI resistance mutations and offers a tool for a cost-effective monitoring of progression in NSCLC.
Rate of Nucleation in Condensed Systems (1949)

On the basis of the nucleation theory developed by Volmer, Becker, and co-workers, and the theory of absolute reaction rates, an expression is derived for the absolute rate of nucleation in condensed systems.
Self-certified public key generation on the intel mote 2 sensor network platform (2006)

It is widely acknowledged that security will play a key role in the successful design and deployment of wireless sensor networks (WSN). A prerequisite for achieving security is the ability to dynamically establish a secret key joint to two nodes. Elliptic Curve Cryptography (ECC) has emerged as a suitable public key cryptographic foundation for WSN. This poster will present an efficient ECC-based method for self-certified key generation in resource-constrained sensor nodes. In particular, we provide implementation results on the Intel Mote 2 sensor network platform which demonstrate that such key generation can be established in the order of 60 msec while consuming less than 30 mJ.
The Molecular Pharmacology of Estrogen Receptor Modulators: Implications for the Treatment of Breast Cancer (2005)

In addition to physiologic activities in the reproductive, skeletal, and central nervous systems, estrogens have been shown to play important roles in the aberrant cell proliferation observed in breast and reproductive tract cancers. Not surprisingly, pharmaceuticals that target different steps in the estrogen signal transduction pathway have found widespread use in the treatment of a wide variety of estrogen-linked disorders. The goal of this review is to outline what is known about the molecular pharmacology of the estrogen receptor and discuss how this information can be used to guide selection of drugs for a particular therapeutic application, and identify new targets where pharmaceutical exploitation could yield novel therapeutics.
Bone Marrow Infusion in Adults (1997)

This study emphasizes the importance and feasibility of the intraosseous route for infusion of fluids and medications in emergency situations in adults. The use of an impact, high speed automatic needle insertion device provides a higher success rate of vascular access via the intraosseal route in adult patients.