gebhart/patrepeval huggingface dataset:
Calcined Clay as Supplementary Cementitious Material (2020)

Calcined clays are the only potential materials available in large quantities to meet the requirements of eco-efficient cement-based materials by reducing the clinker content in blended cements or reducing the cement content in concrete. More than 200 recent research papers on the idea of replacing Portland cement with large amounts of calcined clay are presented and discussed in detail. First, the fundamental information about the properties and structure of clay minerals is described. Then, the process of activation and hydration of clays is discussed, including the methods of pozzolanic activity assessment. Additionally, various testing methods of clays from different worldwide deposits are presented. The application of calcined clay in cement and concrete technology is then introduced. A separate chapter is devoted to lime calcined clay cement. Then an influence of calcined clay on durability of concrete is summarized. Finally, conclusions are formulated.
Study on Phylogenetic Relationships, Variability, and Correlated Mutations in M2 Proteins of Influenza Virus A (2011)

M2 channel, an influenza virus transmembrane protein, serves as an important target for antiviral drug design. There are still discordances concerning the role of some residues involved in proton transfer as well as the mechanism of inhibition by commercial drugs. The viral M2 proteins show high conservativity; about 3/4 of the positions are occupied by one residue in over 95%. Nine M2 proteins from the H3N2 strain and possibly two proteins from H2N2 strains make a phylogenic cluster closely related to 2RLF. The variability range is limited to 4 residues/position with one exception. The 2RLF protein stands out by the presence of 2 serines at the positions 19 and 50, which are in most other M2 proteins occupied by cysteines. The study of correlated mutations shows that there are several positions with significant mutational correlation that have not been described so far as functionally important. That there are 5 more residues potentially involved in the M2 mechanism of action. The original software used in this work (Consensus Constructor, SSSSg, Corm, Talana) is freely accessible as stand-alone offline applications upon request to the authors. The other software used in this work is freely available online for noncommercial purposes at public services on bioinformatics such as ExPASy or NCBI. The study on mutational variability, evolutionary relationship, and correlated mutation presented in this paper is a potential way to explain more completely the role of significant factors in proton channel action and to clarify the inhibition mechanism by specific drugs.
Synthetic Octacalcium Phosphate Augments Bone Regeneration Correlated with Its Content in Collagen Scaffold (2008)

Previous studies have shown that synthetic octacalcium phosphate (OCP) facilitates in vitro osteoblastic cell differentiation in an OCP dose-dependent manner and that a complex of OCP and collagen (OCP/collagen) enhances critical-sized rat calvaria defects more than OCP alone. The present study was designed to investigate whether the bone regenerative properties of OCP/collagen are augmented in an OCP dose-dependent manner, thereby establishing a suitable composition of this composite as a bone substitute material. OCP/collagens with a wide range of mixing ratios from 23:77 to 83:17, including the previously examined composition (77:23), were prepared by blending granules of OCP with atelocollagen and molded into a disk as an implant. A critical-sized defect was made in rat calvaria, and each disk was implanted into the defect for 4 or 12 weeks and then examined radiographically, histologically, and histomorphometrically. Mouse bone marrow-derived stromal ST-2 cells were cultured in dishes pre-coated with OCP/collagen or OCP alone with different OCP contents to determine the capacity of cell attachment and proliferation up to 14 days. Histological and radiographic examinations showed that newly formed bone was observed in relation to OCP granules within the collagen matrix. Histomorphometric analysis confirmed that increasing the amount of OCP in collagen matrices resulted in progressive enhancement of bone regeneration and that the ratio 83:17 generated the maximum repair level of approximately 64% of the defect at 12 weeks. OCP/collagen promoted the proliferation and attachment of ST-2 cells more than OCP alone regardless of OCP content. Fourier transform infrared spectroscopy analysis of the coatings after the incubation indicated that OCP tended to convert to apatite regardless of the presence of collagen. The present study demonstrated that the osteoconductive characteristics of OCP/collagen can be displayed in an OCP dose-dependent manner. The results suggest that collagen promotes the proliferation and attachment of host osteoblastic cells on OCP/collagen composite implants.
Static profile and dynamic behavior of COBOL programs (1978)

A measurement system for gathering a static profile and dynamic characteristics of COBOL programs at the source language level is described. Static and dynamic results are presented and discussed.
An Open Forensic Unit for the Borderline Mentally Impaired Offender (1988)

Over recent years attention has been directed towards providing appropriate facilities for the mentally abnormal offender. In the past such individuals were probably absorbed into the hospital system. However, the open door policy of the 1960s and 1970s, together with hospital closures and reduced bed numbers, has meant that this invisible absorption has been unable to continue. It has been suggested that many of these mentally abnormal offenders are inappropriately placed within the penal system, thus contributing to prison overcrowding. The Butler and Glancy Reports recommended Regional Secure Units as a possible solution. At the beginning of 1987, 14 of these had opened. The tendency has been for Regional Secure Units to deal mainly with the mentally ill offenders and the needs of the mentally impaired have been largely overlooked. The literature on the subject of this latter group has been sparse. Craft described an isolated unit in Wales, which dealt with mentally abnormal offenders, and there are hospitals which provide secure facilities for the mentally handicapped. The purpose of this study is to describe the characteristics of the patients admitted to an open forensic unit in order to assess the suitability of the facilities and the outcome of the treatment provided.
Evaluation of a Moire imaging system (1979)

Moiré fringe techniques can be used to measure surface topography. The factors that affect the formation of the fringes have been assessed theoretically by developing models of gratings and light sources of finite dimensions. In this way the effect of parameters such as the intensity distribution of the light source, the viewing aperture function, the lateral displacement of the source relative to the viewing axis, the viewing distance, the grating spacing and grating ratio have been evaluated. Other factors, related to the physical properties and geometry of the reflecting surface, are also investigated. Suggestions are made for the design of an optimum moiré imaging system.
Review of fish swimming modes for aquatic locomotion (1999)

Several physico-mechanical designs evolved in fish are currently inspiring robotic devices for propulsion and maneuvering purposes in underwater vehicles. Considering the potential benefits involved, this paper presents an overview of the swimming mechanisms employed by fish. The motivation is to provide a relevant and useful introduction to the existing literature for engineers with an interest in the emerging area of aquatic biomechanisms. The fish swimming types are presented, following the well-established classification scheme and nomenclature originally proposed by Breder. Fish swim either by body and/or caudal fin (BCF) movements or using median and/or paired fin (MPF) propulsion. The latter is generally employed at slow speeds, offering greater maneuverability and better propulsive efficiency, while BCF movements can achieve greater thrust and accelerations. For both BCF and MPF locomotion, specific swimming modes are identified, based on the propulsor and the type of movements (oscillatory or undulatory) employed for thrust generation. Along with general descriptions and kinematic data, the analytical approaches developed to study each swimming mode are also introduced. Particular reference is made to lunate tail propulsion, undulating fins, and labriform (oscillatory pectoral fin) swimming mechanisms, identified as having the greatest potential for exploitation in artificial systems.
Event ordering in a shared memory distributed system (2002)

Past research has concentrated on ordering events in a system where processes communicate through messages. The authors look at issues in ordering events in a distributed system based on shared objects that interact via remote procedure calls (RPCs). They derive clock conditions for ordering operations on an object and provide clock maintenance schemes for time-stamping execution events. An object clock is associated with every shared object for clock exchange among processes. A clock maintenance algorithm is incrementally presented for objects where operations are atomic and an algorithm is described for large-grained objects where operations are nested and non-atomic.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Silicon symptoms to solutions: applying design for debug techniques (2003)

Quick and accurate silicon debug is essential for short time to market schedules. This paper describes several actual silicon debug test cases to illustrate both the range of issues found only after silicon is available as well as the range of design for debug features used in the diagnostic process. Each test case starts with the symptoms found on the silicon and follows through to the problem definition and resolution. The debug test cases cover issues from logic and circuit errors to process issues. The designs in the test cases include Motorola's MPC7410 and MPC7450 advanced microprocessors and DSP56621 digital signal processor.
Electrical and optical properties of sputtered TiN<i>x</i> films as a function of substrate deposition temperature (1986)

Characterization results are given for a set of TiNx films grown on sapphire substrates at temperatures between 140 and 850 °C. A relationship between resistivity and spectral reflectivity is established, with highest reflectivities and lowest resistivities observed for the highest substrate temperatures. It is found that grain orientation within the films is random except at the highest deposition temperature where a preferred 100 orientation is indicated. Measurement of the superconducting transition temperature, lattice parameter, and microcrystalline texture of each film has been made and correlated with the stoichiometry, electrical, and optical properties.
Recombinant Human VEGF(165)b Inhibits Experimental Choroidal Neovascularization (2010)

PURPOSE. Vascular endothelial growth factor (VEGF-A) is the principal stimulator of angiogenesis in wet age-related macular degeneration (AMD). However, VEGF-A is generated by alternate splicing into two families, the proangiogenic VEGF-A(xxx) family and the antiangiogenic VEGF-A(xxx)b family. It is the proangiogenic family that is responsible for the blood vessel growth seen in AMD.METHODS. To determine the role of antiangiogenic isoforms of VEGF-A as inhibitors of choroidal neovascularization, the authors used a model of laser-induced choroidal neovascularization in the mouse eye and investigated VEGF-A(165)b effects on endothelial cells and VEGFRs in vitro.RESULTS. VEGF-A(165)b inhibited VEGF-A(165)-mediated endothelial cell migration with a dose effect similar to that of ranibizumab and bevacizumab and 200-fold more potent than that of pegaptanib. VEGF-A(165)b bound both VEGFR1 and VEGFR2 with affinity similar to that of VEGF-A(165). After laser injury, mice were injected either intraocularly or subcutaneously with recombinant human VEGF-A(165)b. Intraocular injection of rhVEGF-A(165)b gave a pronounced dose-dependent inhibition of fluorescein leakage, with an IC50 of 16 pg/eye, neovascularization (IC50, 0.8 pg/eye), and lesion as assessed by histologic staining (IC50, 8 pg/eye). Subcutaneous administration of 100 mu g twice a week also inhibited fluorescein leakage and neovascularization and reduced lesion size.CONCLUSIONS. These results show that VEGF-A(165)b is a potent antiangiogenic agent in a mouse model of age-related macular degeneration and suggest that increasing the ratio of antiangiogenic-to-proangiogenic isoforms may be therapeutically effective in this condition. (Invest Ophthalmol Vis Sci. 2010; 51:4282-4288) DOI:10.1167/iovs.09-4360
American Public Health Association/American Academy of Pediatrics Injury Prevention Standards (1994)

Injury prevention is an integral part of quality child-care programs. National standards relating to injury prevention have been published by the APHA and the AAP. The majority of these standards are preventive in nature and stress injury prevention in the development of policies and procedures and in the implementation of daily practices in child-care programs. Although it may not be possible to prevent all injuries in child-care settings, it is important for care givers, parents, and health professionals to identify potential hazards in the child-care environment. Once these hazards are identified, preventive corrective actions directed toward both environmental modifications and individual behaviors can be promoted to keep the incidence of injuries as low as possible.
Effect of casting conditions on the performance of porous cellulose acetate membranes in reverse osmosis (1970)

Abstract Several sets of porous cellulose acetate membranes were made using the same casting solution composition and gelation conditions but varying the casting solution temperature and solvent evaporation conditions. The films were tested in reverse osmosis experiments at 250 psig using aqueous feed solutions containing 3500 ppm NaCl. The results show that the product rate obtained at a given level of solute separation is independent of evaporation time in the range tested and, for a given casting solution composition, the temperature of the casting solution and conditions of solvent evaporation during film formation together constitute an important interconnected variable governing the porous structure of the resulting membranes. These results offer a new approach to the problem of developing more productive reverse osmosis membranes and have led to a new class of porous cellulose acetate membranes capable of giving product rates 100% to 150% higher than those of the best membranes reported, at any given level of solute separation under the experimental conditions used. These results are of practical importance in low‐pressure reverse osmosis applications.
Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin‐10 in interferon‐γ and in interleukin‐4‐expressing cells (1994)

In an immune response, effector functions are controlled by T helper (Th) 1 cytokines [interferon-gamma (IFN-gamma), interleukin (IL)-2 and tumor necrosis factor-beta] and Th2 cytokines (IL-4, IL-5 and IL-10). Here we analyze by multiparameter immunofluorescence to what extent IL-2, IL-4, IL-5, IL-10 and IFN-gamma are co-expressed in individual normal murine Th cells upon activation in vitro with the bacterial superantigen Staphylococcus aureus enterotoxin B, presented in the context of major histocompatibility complex class II. IL-2 and IFN-gamma are co-expressed by some, but not by other Th cells. Expression of IL-4 and IFN-gamma is exclusive. IL-10 is co-expressed in individual cells either with IL-4 or with IFN-gamma. No IL-5-expressing cells are detected. While IL-10- and IL-4-co-expressing Th cells correspond to classical Th 2 cells, cells co-expressing IL-10 and IFN-gamma could be involved in negative-feedback regulation of a Th1 response. Apart from such functional implications, our results show that IL-2, IL-4, IL-5, IL-10 and IFN-gamma are expressed independently of each other in individual murine Th cells.
Nuclear Protein Transpor (1989)

The nucleus, like all organelles, is composed of a unique set of proteins. This article discusses the possible mechanisms for localization of only certain proteins to the nucleus, transport of proteins across the nuclear envelope, and retention of proteins in the nuclear interior. In addition, nuclear protein transport is compared with transport of proteins into the endoplasmic reticulum and the mitochondria.
Nucleic acid binding and chaperone properties of HIV-1 Gag and nucleocapsid proteins (2006)

The Gag polyprotein of HIV-1 is essential for retroviral replication and packaging. The nucleocapsid (NC) protein is the primary region for the interaction of Gag with nucleic acids. In this study, we examine the interactions of Gag and its NC cleavage products (NCp15, NCp9 and NCp7) with nucleic acids using solution and single molecule experiments. The NC cleavage products bound DNA with comparable affinity and strongly destabilized the DNA duplex. In contrast, the binding constant of Gag to DNA was found to be approximately 10-fold higher than that of the NC proteins, and its destabilizing effect on dsDNA was negligible. These findings are consistent with the primary function of Gag as a nucleic acid binding and packaging protein and the primary function of the NC proteins as nucleic acid chaperones. Also, our results suggest that NCp7's capability for fast sequence-nonspecific nucleic acid duplex destabilization, as well as its ability to facilitate nucleic acid strand annealing by inducing electrostatic attraction between strands, likely optimize the fully processed NC protein to facilitate complex nucleic acid secondary structure rearrangements. In contrast, Gag's stronger DNA binding and aggregation capabilities likely make it an effective chaperone for processes that do not require significant duplex destabilization.
Optical properties of titania/silica multilayer filters prepared by helicon plasma sputtering (1998)

Seven-layer optical multilayer filters with alternating layers of titania and silica were fabricated by helicon plasma sputtering at room temperature. The reflectance of the filters around the design wavelengths of 800 and 1300 nm are up to 95.80% and 95.32%, respectively. Their reflected bands have the full widths at half maximum of about 360 and 600 nm, respectively. The measured transmittance spectra correspond well with the calculated results based on the optical multilayer film theory with measured refractive indices of 2.44 and 1.48 for TiO2 and SiO2, respectively. Microstructures of the TiO2 and SiO2 films and TiO2/SiO2 multilayer films were investigated.
An effect of K-ras gene mutation on epidermal growth factor receptor signal transduction in PANC-1 pancreatic carcinoma cells (1996)

The Ras protein is involved in tyrosine kinase signal transduction pathway steps such as EGFR signalling. Most human pancreatic carcinomas harbor a point mutation of K-ras oncogene and overexpress transforming TGF-alpha. We studied how K-ras gene mutation could influence the EGFR signal transduction mechanism and the autonomous proliferation of pancreatic carcinoma cells, using PANC-1 human pancreatic carcinoma line and W1-38 normal human fibroblast cell line as a control. PANC-1 cells responded to neither EGF nor exogenous TGF-alpha, although anti-TGF-alpha MAb suppressed their growth. Expression of TGF-alpha mRNA was detected only in PANC-1 cells, which confirmed EGFR being within an autocrine loop. Ras protein and MAP kinase were constitutively activated in PANC-1 cells so that the cells did not respond to treatment with staurosporine or herbimycin A, and exhibited slight response to EGF stimulation. PANC-1 cells harbored K-ras gene mutation in codon 12. In contrast, EGF stimulation induced an elevation of GTP-bound ratio to Ras protein and an activation of MAP kinase with accelerated growth in W1-38 cells. From these findings, we concluded that K-ras gene mutation possibly plays an important role in the autonomous proliferation of PANC-1 pancreatic carcinoma cells, and that an autocrine loop represented by TGF-alpha and EGFR may further accelerate the growth of PANC-1 cells.
AN ATTITUDE CONTROL SYSTEM TO CONSTRAIN THE SKIN TEMPERATURE OF A MANNED LIFTING SPACECRAFT DURING REENTRY INTO THE EARTH'S ATMOSPHERE (1967)

Abstract : An attitude control system to regulate the temperature of a manned lifting spacecraft during reentry into the Earth's atmosphere is proposed. Its use prevents the peak skin temperature that is experienced during the reentry from rising moderately beyond that which would occur during an equilibrium glide of the same vehicle. The effects of Earth rotation and oblateness upon the performance of the attitude control system were found to be moderate and predictable. The maximum temperature increment associated with them was found to be only 100F for the worst set of initial conditions. The cross range shift of the footprint due to rotation was found to be within 70 miles of the value that would occur for the corresponding orbit in vacuum. Oblateness could generally be accounted for by using the effective initial glide angle relative to the Earth's surface rather than the geocentric initial value relative to the central coordinate system. The results of density variation in the Earth's atmosphere were not serious. Large increases in the maximum skin temperature occurred only when extremely large spatially random density disturbances were encountered by the vehicle.
To Be or Not to Be: Mutually Antagonistic Death Signals Regulate Thymocyte Apoptosis (1994)

Recognition of self-antigens by immature thymocytes results in either activation-induced apoptosis (negative selection) or survival (positive selection). While it is believed that T cell receptor avidity plays a role in determining the outcome, the mechanisms responsible for this life or death decision are not known. Recent data concerning the mutual antagonism between activation- and glucocorticoid-induced apoptosis have prompted an examination of the potential interaction of these two signaling pathways in the regulation of antigen-specific selection.
Comparative genomics of bacteria from the genus <i>Collimonas</i> : linking (dis)similarities in gene content to phenotypic variation and conservation (2012)

Collimonas is a genus of soil bacteria comprising three recognized species: C. fungivorans, C. pratensis and C. arenae. Collimonads share the ability to degrade chitin (chitinolysis), feed on living fungal hyphae (mycophagy), and dissolve minerals (weathering), but vary in their inhibition of fungi (fungistasis). To better understand this phenotypic variability, we analysed the genomic content of four strains representing three Collimonas species (Ter14, Ter6, Ter91 and Ter10) by hybridization to a microarray based on reference strain C. fungivorans Ter331. The analysis revealed genes unique to strain Ter331 (e.g. those on the extrachromosomal element pTer331) and genes present in some but not all of the tested strains. Among the latter were several candidates that may contribute to fungistasis, including genes for the production and secretion of antifungals. We hypothesize that differential possession of these genes underlies the specialization of Collimonas strains towards different fungal hosts. We identified a set of 136 genes that were common in all tested Collimonas strains, but absent from the genomes of three other members of the family Oxalobacteraceae. Predicted products of these 'Collimonas core' genes include lytic, secreted enzymes such as chitinases, peptidases, nucleases and phosphatases with a putative role in mycophagy and weathering.