gebhart/patrepeval huggingface dataset:
Problems in the Use of Serologic Tests for the Diagnosis of Lyme Disease (1991)

Lyme disease can be reliably diagnosed in the presence of erythema migrans. When erythema migrans is absent, serologic tests are often used to confirm the diagnosis. To choose a test for our Lyme disease diagnostic center, serum samples were obtained from 34 patients and tested for antibodies to Borrelia burgdorferi. We evaluated five enzyme-linked immunosorbent assays from Stony Brook (NY) University Hospital, Cambridge Bioscience (Worcester, Mass), Hillcrest Biologicals (Cypress, Calif), Sigma Diagnostics (St Louis, Mo), and Zeus-Wampole Scientific Inc (Raritan, NJ) and two fluorescent antibody tests (3M [Diagnostic Systems Inc, Santa Clara, Calif] and FIAX [Whittaker M.A. Bioproducts Inc, Walkersville, Md]). A positive sample by any test was further analyzed by Western blot. Using the Centers for Disease Control (Atlanta, Ga) epidemiologic case definitions, patients were classified into those with clinical Lyme disease, patients not meeting the Centers for Disease Control definitions, and asymptomatic patients. Sensitivities of Lyme serologies varied from 13% to 73%, with Hillcrest showing the highest value and Sigma the lowest value. False-positive test results were found in 0% to 27% of patients. Western blot analysis was positive in six of 15 patients with clinical Lyme disease. These results emphasize the need for better serologic testing for Lyme disease and underline their usefulness only as adjuncts in the clinical diagnosis of Lyme disease.
Combination Ciprofloxacin and Metronidazole for Active Crohn’s Disease (1998)

Recent experimental evidence underscores the contribution of intestinal bacteria to the inflammatory process of Crohn's disease. This open study examined the efficacy and safety of combination ciprofloxacin and metronidazole for patients with active Crohn's disease of the ileum and/or colon. Seventy-two patients with active Crohn's disease of the ileum (n = 27), ileocolon (n = 22) or colon (n = 23) were treated with ciprofloxacin 500 mg bid and metronidazole 250 mg tid for a mean of 10 weeks. Clinical remission was defined as a Harvey-Bradshaw index of three points or less; an index reduction of at least three points indicated a clinical response. Clinical remission was observed in 49 patients (68%), and 55 patients (76%) showed a clinical response. A clinical response was noted in 29 of 43 patients (67%) who were not taking concurrent prednisone treatment and in 26 of 29 patients (90%) receiving prednisone (mean dose of 15 mg/day). A clinical response also occurred in a greater proportion of patients with colonic disease, with or without ileal involvement (84%), compared with patients with ileal disease alone (64%), and in patients without resection (86%) compared with those with previous resection (61%). Five patients discontinued antibiotics because of adverse events. After a mean follow-up of nine months, clinical remission was maintained in 26 patients off treatment and in 12 patients who continued antibiotic therapy. Ciprofloxacin in combination with metronidazole is well tolerated and appears to play a beneficial role in achieving clinical remission for patients with active Crohn's disease, particularly when there is involvement of the colon.
Dementia with Lewy Bodies: Review and Pharmacotherapeutic Implications (1999)

Alzheimer's disease accounts for 50-60% of dementia cases in older people. Dementia with Lewy bodies is now recognized as the second most common type of dementia. It is different from Alzheimer's disease and has important pharmacotherapeutic implications. Key features include early-onset, persistent, well-formed, visual hallucinations and motor features of parkinsonism. Pharmacologic management of neurobehavioral symptoms is complicated by an exaggerated response to neuroleptics, which causes excessive morbidity and mortality. Patients with dementia with Lewy bodies may be particularly responsive to cholinesterase inhibitors. When neurobehavioral symptoms are severe enough to require pharmacologic intervention, it is recommended that agents such as trazodone or cholinesterase inhibitors be considered first-line therapy. If these fail, neuroleptics may be prescribed with caution.
Action of spontaneously produced beta interferon in differentiation of embryonal carcinoma cells through an autoinduction mechanism. (1993)

In the current study, we have addressed the role of interferons (IFNs) in controlling the differentiation of pluripotent P19 embryonal carcinoma (EC) cells. Blocking IFN activity in the culture medium of differentiating cells with antibodies leads to a strong decrease in the degree of differentiation. The antibodies are active for a relatively short time. During this time, IFN-beta mRNA can be detected in the differentiating cells, as can increases of IFN stimulation response element-binding activity and NF-KB. The timing of IFN action also coincides with the accumulation of cytoplasmic double-stranded RNA (dsRNA) and with a drop in dsRNA unwindase-modificase activity. A model for the involvement of autoinduction of IFN by intracellular dsRNA in the control of differentiation in this system is presented.
No-Choice Preference of <I>Cerotoma trifurcata</I> (Coleoptera: Chrysomelidae) to Potential Host Plants of Bean Pod Mottle Virus (<I>Comoviridae</I>) in Iowa (2007)

To better understand the naturally occurring host range of Bean pod mottle virus (family Comoviridae, genus Comovirus, BPMV) and its principal vector Cerotoma trifurcata (Förster) (Coleoptera: Chrysomelidae), 18 field-collected perennial plant species were tested for the presence of BPMV. By using no-choice assays, we determined the preference of these plants by bean leaf beetle, by measuring their level of herbivory relative to soybean, Glycine max (L.). New food hosts for adult bean leaf beetles include Lespedeza capitata (Michaux), Lotus corniculatus L., Trifolium alexandrinum L., Trifolium ambiguum Bieberstein, and Trifolium incarnatum L. Desmodium illinoense Gray is discovered as a new naturally occurring host for BPMV.
Pseudomorphic n-InGaP/InGaAs/GaAs high electron mobility transistors for low-noise amplifiers (1993)

The authors developed 0.15- mu m-gate pseudomorphic n-InGaP/InGaAs/GaAs HEMTs for low-noise amplifiers. Passivated devices exhibited a noise figure of 0.41 dB with an associated gain of 13.0 dB at 12 GHz including package loss, and of 1.2 dB with an associated gain of 5.8 dB at 50 GHz. Reducing the short-channel effects was the key to achieving the best performance ever reported for passivated and packaged low-noise HEMTs on GaAs substrates. A high aspect ratio under the thin n-InGaP layer and good carrier confinement in the pseudomorphic InGaAs channel reduce the undesirable short-channel effects in these devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Growth Suppression by Acute PromyelocyticLeukemia-Associated Protein PLZF Is Mediated by Repression of c-myc Expression (2003)

The transcriptional repressor PLZF was identified by its translocation with retinoic acid receptor alpha in t(11;17) acute promyelocytic leukemia (APL). Ectopic expression of PLZF leads to cell cycle arrest and growth suppression, while disruption of normal PLZF function is implicated in the development of APL. To clarify the function of PLZF in cell growth and survival, we used an inducible PLZF cell line in a microarray analysis to identify the target genes repressed by PLZF. One prominent gene identified was c-myc. The array analysis demonstrated that repression of c-myc by PLZF led to a reduction in c-myc-activated transcripts and an increase in c-myc-repressed transcripts. Regulation of c-myc by PLZF was shown to be both direct and reversible. An interaction between PLZF and the c-myc promoter could be detected both in vitro and in vivo. PLZF repressed the wild-type c-myc promoter in a reporter assay, dependent on the integrity of the binding site identified in vitro. PLZF binding in vivo was coincident with a decrease in RNA polymerase occupation of the c-myc promoter, indicating that repression occurred via a reduction in the initiation of transcription. Finally, expression of c-myc reversed the cell cycle arrest induced by PLZF. These data suggest that PLZF expression maintains a cell in a quiescent state by repressing c-myc expression and preventing cell cycle progression. Loss of this repression through the translocation that occurs in t(11;17) would have serious consequences for cell growth control.
Oxygen barrier efficiency of hexamethyldisiloxane/oxygen plasma-deposited coating (1996)

Oxygen barrier coatings were made by plasma polymer deposition on a polypropylene substrate. Plasma polymer deposition is realized in a low-frequency reactor with hexamethyldisiloxane/oxygen (HMDSO/O2) precursors. The structure and composition of the deposited coating are characterized by density measurements and FTIR spectroscopy. Permeability of the polypropylene, coated with plasma films made from various gas compositions, is interpreted in terms of coating structure and composition. Incorporation of molecular oxygen in the gas phase results in inorganic and dense films. It is shown that the density of the film is the main factor controlling the oxygen barrier effect. © 1996 John Wiley & Sons, Inc.
3D action matching with key-pose detection (2009)

This paper addresses the problem of human action matching in outdoor sports broadcast environments, by analysing 3D data from a recorded human activity and retrieving the most appropriate proxy action from a motion capture library. Typically pose recognition is carried out using images from a single camera, however this approach is sensitive to occlusions and restricted fields of view, both of which are common in the outdoor sports environment. This paper presents a novel technique for the automatic matching of human activities which operates on the 3D data available in a multi-camera broadcast environment. Shape is retrieved using multi-camera techniques to generate a 3D representation of the scene. Use of 3D data renders the system camera-pose-invariant and allows it to work while cameras are moving and zooming. By comparing the reconstructions to an appropriate 3D library, action matching can be achieved in the presence of significant calibration and matting errors which cause traditional pose detection schemes to fail. An appropriate feature descriptor and distance metric are presented as well as a technique to use these features for key-pose detection and action matching. The technique is then applied to real footage captured at an outdoor sporting event.
Teatro na Prisão: A Extensão e a Pesquisa como caminhos formativos em Pedagogia do Teatro (2020)

Este relato refere-se a uma experiência discente junto a uma ação de extensão e a um projeto de pesquisa sobre Teatro e Educação Penitenciária promovido pelo Curso de Licenciatura em Teatro da Universidade Federal do Amapá - UNIFAP. Procuramos discorrer sobre a participação junto ao projeto temático e como a prática extensionista se transformou em investigação científica sobre a relação do fazer teatral junto ao espaço prisional e o reflexo destas ações na formação discente/docente dos licenciandos do curso em questão.
Rapid Analysis of Hemoglobin from Whole Human Blood by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry (1997)

Matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOFMS) is applied to the analysis of whole human blood. No separation or purification steps are required to observe individual globins and the sensitivity of the method is excellent. Mass accuracy and precision are 0.01% using a linear TOF system with pulsed ion extraction. Sickle-cell hemoglobin is easily distinguishable from normal hemoglobin. The speed and simplicity of the method make it potentially attractive for large-scale population screening.
A new multiple quantum filter design procedure for use on strongly coupled spin systems found <i>in vivo</i>: Its application to glutamate (1998)

A numerical procedure is outlined that is appropriate for the design of multiple quantum filter sequences targeted for the strongly coupled, multiple spin systems that occur in metabolites present in brain. The procedure uses numerical methods of solution of the density matrix equations, first, to establish the most appropriate resonance to target with the filter; second, to provide contour plots of a performance index of the filter in terms of critical sequence parameters; and third, to produce the response signals of the target and the background metabolites to the optimized filter. The procedure is exemplified for the AMNPQ spin system of the amino acid glutamate at a field strength of 3 T. The 2.3 ppm peak of the PQ multiplet of glutamate was identified as the target resonance, and the performance of the filter so derived was evaluated experimentally on phantom solutions and in human brain. These experiments clearly demonstrate that a linewidth of <or=4 Hz is required for full resolution of glutamate from glutamine at 3 T using this double quantum filter. Nevertheless, even at a linewidth of approximately 7 Hz in vivo, the 2.3 ppm peak of glutamate dominates the filter response and thereby removes a significant cause of uncertainty in measuring changes in glutamate by eliminating most of the background observed in unedited spectra obtained using PRESS or STEAM.
IN VITRO ANTIOXIDANT AND ANTICANCER ACTIVITIES OF EXTRACTS FROM A FERMENTED FOOD (2003)

Solvent extracts were prepared from Manda Enzyme®, one of the fermented health foods, and their activities of radical scavenging and cancer cell growth inhibition were evaluated. Manda Enzyme® was extracted with 55% ethanol, and then fractionated into n-hexane, chloroform, ethyl acetate, methanol-soluble and methanol-insoluble fractions. The antioxidant activities were in the order chloroform > ethyl acetate > other fractions and of each fraction were positively related to the amount of total phenolics and the intensity of brown color. The cancer cell growth inhibitory activities were in the order n-hexane > chloroform > other fractions. Proliferation of HRT-18, HCT-48 and HepG2 human cancer cells was inhibited by the treatment of the n-hexane fraction of Manda Enzyme® at a concentration of 400 μg/mL to the extent of 75, 89 and 90%, respectively. From these results, it is considered that Manda Enzyme® has chemically different ingredients showing strong antioxidant and anticancer activity in vitro.
Dysregulation of apoptosis in hepatocellular carcinoma cells (2009)

Hepatocellular carcinoma (HCC) is a major health problem, being the sixth most common cancer world-wide. Dysregulation of the balance between proliferation and cell death represents a pro-tumorigenic principle in human hepatocarcinogenesis. This review updates the recent relevant contributions reporting molecular alterations for HCC that induce an imbalance in the regulation of apoptosis. Alterations in the expression and/or activation of p53 are frequent in HCC cells, which confer on them resistance to chemotherapeutic drugs. Many HCCs are also insensitive to apoptosis induced either by death receptor ligands, such as FasL or TRAIL, or by transforming growth factor-beta (TGF-beta). Although the expression of some pro-apoptotic genes is decreased, the balance between death and survival is dysregulated in HCC mainly due to overactivation of anti-apoptotic pathways. Indeed, some molecules involved in counteracting apoptosis, such as Bcl-X(L), Mcl-1, c-IAP1, XIAP or survivin are over-expressed in HCC cells. Furthermore, some growth factors that mediate cell survival are up-regulated in HCC, as well as the molecules involved in the machinery responsible for cleavage of their pro-forms to an active peptide. The expression and/or activation of the JAK/STAT, PI3K/AKT and RAS/ERKs pathways are enhanced in many HCC cells, conferring on them resistance to apoptotic stimuli. Finally, recent evidence indicates that inflammatory processes, as well as the epithelial-mesenchymal transitions that occur in HCC cells to facilitate their dissemination, are related to cell survival. Therefore, therapeutic strategies to selectively inhibit anti-apoptotic signals in liver tumor cells have the potential to provide powerful tools to treat HCC.
Malware Signature Generation Using Locality Sensitive Hashing. (2018)

Security threats due to malicious executable are getting more serious. A lot of researchers are interested in combating malware attacks. In contrast, malicious users aim to increase the usage of polymorphism and metamorphism malware in order to increase the analysis cost and prevent being identified by anti-malware tools. Due to the intuitive similarity between different polymorphisms of a malware family, clustering is an effective approach to deal with this problem. Clustering accordingly is able to reduce the number of signatures. Therefore, we have leveraged the Suffix tree structure and Locality Sensitive Hashing (LSH) to linearly cluster malicious programs and to reduce the number of signatures significantly.
Number, Density, and Surface/Cytoplasmic Distribution of GABA Transporters at Presynaptic Structures of Knock-In Mice Carrying GABA Transporter Subtype 1–Green Fluorescent Protein Fusions (2002)

GABA transporter subtype 1 (GAT1) molecules were counted near GABAergic synapses, to a resolution of approximately 0.5 microm. Fusions between GAT1 and green fluorescent protein (GFP) were tested in heterologous expression systems, and a construct was selected that shows function, expression level, and trafficking similar to that of wild-type (WT) GAT1. A strain of knock-in mice was constructed that expresses this mGAT1-GFP fusion in place of the WT GAT1 gene. The pattern of fluorescence in brain slices agreed with previous immunocytochemical observations. [3H]GABA uptake, synaptic electrophysiology, and subcellular localization of the mGAT1-GFP construct were also compared with WT mice. Quantitative fluorescence microscopy was used to measure the density of mGAT1-GFP at presynaptic structures in CNS preparations from the knock-in mice. Fluorescence measurements were calibrated with transparent beads and gels that have known GFP densities. Surface biotinylation defined the fraction of transporters on the surface versus those in the nearby cytoplasm. The data show that the presynaptic boutons of GABAergic interneurons in cerebellum and hippocampus have a membrane density of 800-1300 GAT1 molecules per square micrometer, and the axons that connect boutons have a linear density of 640 GAT1 molecules per micrometer. A cerebellar basket cell bouton, a pinceau surrounding a Purkinje cell axon, and a cortical chandelier cell cartridge carry 9000, 7.8 million, and 430,000 GAT1 molecules, respectively; 61-63% of these molecules are on the surface membrane. In cultures from hippocampus, the set of fluorescent cells equals the set of GABAergic interneurons. Knock-in mice carrying GFP fusions of membrane proteins provide quantitative data required for understanding the details of synaptic transmission in living neurons.
Simulation, design and test of a MOV pulse shaping device for high power microwave generators (2003)

This paper describes a metal oxide varistor (MOV) pulse shaping device, which is to be used for generating a flat-top voltage pulse for high power microwave devices. The MOV pulse-shaping device is attached to a coaxial pulse compression system. The pulse compression system consists of an inductive energy storage section, an exploding wire fuse and an output spark gap. The paper contains a detailed discussion of the pulse compression system followed by a description of the MOV pulse-shaping device. The MOV elements that are used for this pulse shaping application are the SIOV-E32VR602 type, made by Siemens.
Wiring of Enzymes to Electrodes by Ultrathin Conductive Polyion Underlayers:  Enhanced Catalytic Response to Hydrogen Peroxide (2003)

Stable electroactive films were grown layer by layer on rough pyrolytic graphite electrodes featuring 4-nm underlayers of sulfonated polyaniline (SPAN) covered with a film containing myoglobin or horseradish peroxidase grown in alternating layers with poly(styrenesulfonate). The self-doped polyanionic SPAN layer, grown on a 2-nm polycation layer, was conductive between about 0.1 and -0.4 V vs SCE at pH 4.5. The enzyme films had the architecture PDDA/SPAN/(enzyme/PSS)3, where PDDA is poly(diallyldimethylammonium) ion. Comparisons of voltammetric measurements of electroactive protein with quartz crystal microbalance measurements of total protein showed that 90% or more of the protein was coupled to the electrode when the SPAN underlayer was present, as opposed to approximately 40% protein electroactivity when SPAN was absent. As a consequence of the highly efficient coupling between enzymes and electrode, the PDDA/SPAN/(enzyme/PSS)3 films exhibited a higher sensitivity for the electrochemical catalytic reduction of hydrogen peroxide. Amperometry at a rotating disk electrode at 0 V gave sensitivity for hydrogen peroxide up to 14 microA microM(-1) cm(-2) in the submicromolar concentration range and a detection limit of approximately 3 nM. Results suggest the future utility of ultrathin layers of conductive self-doping polyions in improving sensitivity of enzyme biosensors.
Ferrimagnetic Domain Wall Motion Induced by Damping-like Spin-orbit Torque (2018)

We theoretically and numerically investigate ferrimagnetic domain wall motion driven by damping-like spinorbit torque. We find that the damping-like spin-orbit torque combined with the interfacial Dzyaloshinskii-Moriya interaction efficiently drives the ferrimagnetic domain wall especially at the angular momentum compensation point. We obtain the analytic expression of the domain wall velocity with respect to the current density and the net spin density, which is in agreement with numerical simulation. The analytic expression is applicable to arbitrary compensation conditions, ranging from the ferromagnetic limit to the antiferromagnetic limit, and is thus useful to design and interpret ferrimagnetic domain wall experiments at various temperatures or compositions.
Wavenumber-Frequency Spectra of Turbulent Boundary Layer Pressure Measured by Microphone Arrays (1970)

Measurements of frequency spectra of smooth-wall pressures have been made by single microphones and by a longitudinal array of four flush 0.8-in. circular microphones connected with alternating and with common phase. The microphones were selected to suppress high wavenumbers. The measured levels set upper limits on low-wavenumber boundary-layer pressure. The array was designed to suppress, by its wavenumber filtering, the background acoustic duct noise at frequencies near 3 kHz. Analysis indicates that a very high phase-speed low wavenumber pressure field dominates near this frequency. At low frequencies, single-microphone and array spectra are dominated by the convective wavenumber component of boundary-layer pressure and satisfactory agreement is found with theoretical predictions. [This work was supported by the Acoustics Branch of the Office of Naval Research.]