gebhart/patrepeval huggingface dataset:
An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer (2015)

Epithelial cell adhesion molecule (EpCAM) is known to be overexpressed in epithelial cancers associated with enhanced malignant potential, particularly colorectal carcinoma (CRC) and head and neck squamous cell carcinoma (HNSCC). However, it is unknown whether progression of malignance can be directly inhibited by targeting EpCAM. Here, we have generated five novel monoclonal antibodies (mAbs) against EpCAM. One of these anti-EpCAM mAbs, EpAb2-6, was found to induce cancer cell apoptosis in vitro, inhibit tumor growth, and prolong the overall survival of both a pancreatic cancer metastatic mouse model and mice with human colon carcinoma xenografts. EpAb2-6 also increases the therapeutic efficacy of irinotecan, fluorouracil, and leucovorin (IFL) therapy in a colon cancer animal model and gemcitabine therapy in a pancreatic cancer animal model. Furthermore, EpAb2-6, which binds to positions Y95 and D96 of the EGF-II/TY domain of EpCAM, inhibits production of EpICD, thereby decreasing its translocation and subsequent signal activation. Collectively, our results indicate that the novel anti-EpCAM mAb can potentially be used for cancer-targeted therapy.
‘Those stories look true’: levels of taxation in the reigns of Aethelred II and Cnut (1989)

'Those stories look true': levels of taxation in the reigns of Aethelred II and Cnut Get access M. K. LAWSON M. K. LAWSON St Paul's SchoolLondon Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume CIV, Issue CCCCXI, April 1989, Pages 385–406, https://doi.org/10.1093/ehr/CIV.CCCCXI.385 Published: 01 April 1989
Mesoporous TiO<sub>2</sub>-Based Experimental Layout for On-Target Enrichment and Separation of Multi- and Monophosphorylated Peptides Prior to Analysis with Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry (2011)

A simple method for on-target enrichment and subsequent separation and analysis of phosphorylated peptides is presented. The tryptic digest of a phosphorylated protein, in this case β-casein, is loaded onto a spot on a thin stripe made of mesoporous TiO(2) sintered onto a conductive glass surface. After washing with a salicylic buffer in order to remove the nonphosphorylated peptides, the stripe is placed in an elution chamber containing a phosphate solution. In a way analogous to thin layer chromatography (TLC), the phosphate solution acts as an eluent, clearly separating multi- and monophosphorylated peptides. By performing matrix-assisted laser desorption-ionization mass spectrometry (MALDI-MS) along the stripe, the detection of all phosphorylated peptides present in the digest is facilitated, as they are isolated from each other. The method was also tested on commercial drinking milk, achieving successful separation between multi- and monophosphorylated peptides, as well as a detection limit in the femtomole range. As the enrichment, separation, and analysis take place in the same substrate, sample handling and risk of contamination and sample loss is minimized. The results obtained suggest that the method, once optimized, may successfully provide a complete phosphoproteome.
Photovoltaic effects on Franz–Keldysh oscillations in photoreflectance spectra: Application to determination of surface Fermi level and surface recombination velocity in undoped GaAs∕n-type GaAs epitaxial layer structures (2005)

We demonstrate that the surface Fermi level and surface recombination velocity in undoped GaAs∕n-type GaAs (i-GaAs∕n-GaAs) epitaxial layer structures can be simultaneously estimated from Franz–Keldysh oscillations (FKOs) in photoreflectance spectra, taking account of the photovoltaic effects. Initially, we performed computational studies on the surface electric fields in i-GaAs∕n-GaAs structures under the illumination of a probe beam. The surface electric-field strength is sensitive to the surface Fermi level and surface recombination velocity. We have found that these parameters can be evaluated from the dependence of the surface electric-field strength on the probe-beam power density. Next, we estimated experimentally the surface Fermi level and surface recombination velocity in an as-grown i-GaAs∕n-GaAs structure by analyzing the photovoltaic effect on the FKOs. The period of the FKOs increases with a decrease in the probe-beam power density. The surface Fermi level and surface recombination velocity are estimated from the probe-beam power dependence of the surface electric-field strength that is obtained from the analysis of the FKOs. We have also applied the analysis of the photovoltaic effect to the assessment of the GaAs surfaces exposed to the nitridation and the catalytic chemical vapor deposition of SiNx. In addition, we have derived a line-shape function of the FKOs from i-GaAs∕n-GaAs structures, which is applicable even to the FKOs influenced by a probe-beam interference phenomenon in a layered structure.
Enhanced Fiber Tractography Using Edema Correction: Application and Evaluation in High-Grade Gliomas (2021)

This method of edema correction can be applied to standard clinical DTI to improve visualization of motor and language tracts in patients with glioma-associated peritumoral edema.
Synthesis of CeO2 Spherical Fine Particles by Homogeneous Precipitation Method with Polyethylene Glycol (2002)

Abstract CeO2(IV) fine particles were prepared by heating a polyethylene glycol solution of Ce(NO3)3·6H2O at 383 K for 3 h. When a polyethylene glycol whose molecular weight was 7500 or 20000 was used for the preparation, the obtained CeO2 particles were almost monodispersed.
Part 3 - WiFi Oriented Gesture Control & its application (2013)

This Exploratory Survey paper explore the basic principle behind WiFi oriented Gesture Control System. The paper briefly provided the literature review about this latest technology. This technology having vast applications in real time situation like in Gaming, Home automation, Medicine for disabled & latest electronic gadgets. The researcher from University of Washington has done a milestone work for this technology. It will be expected that in 2020 era, the WiFi based Gesture Control & Recognition system replace all other Man-Machine interface methods.
Endothelial Progenitor Cells: A Promising Therapeutic Alternative for Cardiovascular Disease (2007)

The integrity and functional activity of the endothelial monolayer play a critical role in preventing atherosclerotic disease progression. Endothelial cell (EC) damage by atherosclerosis risk factors can result in EC apoptosis with loss of the integrity of the endothelium. Thus, approaches to repair the injured vessels with the goal of regenerating ECs have been tested in preclinical experimental models and in clinical studies. Indeed, endothelial progenitor cells (EPCs) originating from the bone marrow have been shown to incorporate into sites of neovascularization and home to sites of endothelial denudation. These cells may provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium. Risk factors for coronary artery disease, such as age, smoking, hypertension, hyperlipidemia, and diabetes, however, reduce the number and functional activity of circulating EPCs, potentially restricting the therapeutic prospective of progenitor cells and limiting the regenerative capacity. Furthermore, the impairment of EPCs by risk factors may contribute to atherogenesis and atherosclerotic disease progression. The article reviews the role of EPCs in atherogenesis and in predicting cardiovascular outcomes, and highlights the potential challenges in developing therapeutic strategies aiming to interfere with the balance of injury and repair mechanisms.
Unscented Kalman Filtering based quantized innovation fusion for target tracking in WSN with feedback (2009)

The quantized innovation fusion approach to tracking a target with nonlinear Gaussian dynamics in wireless sensor network (WSN) is proposed. A hierarchical innovation fusion structure with feedback from the fusion center (FC) to each deployed sensor is proposed. The measurement innovation in each local sensor node is quantized and then transmitted to the FC. Then the FC estimates the state of the target using the unscented Kalman filtering (UKF) strategy. To attack the energy/power source and communication bandwidth constraints, we consider the tradeoff between the communication energy and the global tracking accuracy. A closed-form solution to the optimization problem for bandwidth scheduling is given, where the total energy consumption measure is minimized subject to a constraint on the covariance of the quantization noises. Simulation example is given to illustrate the proposed scheme obtains average percentage of communication energy saving up to 41.5% compared with the uniform quantization, while keeping tracking accuracy very closely to the clairvoyant UKF that relies on analog-amplitude measurements.
Profile of ustekinumab and its potential in patients with moderate-to-severe Crohn&#39;s disease (2014)

The advent of anti-tumor necrosis factor (TNF)-α therapy has been a major advance in the medical management of Crohn's disease (CD). However, a significant proportion of patients with CD do not respond adequately to treatment with these agents. Primary and secondary nonresponse to anti-TNFα therapy represents a common clinical challenge, and highlights the need for the development of additional medication options for CD. The proinflammatory cytokines interleukin (IL)-12 and IL-23 are thought to play a key role in the pathogenesis of CD, and serve as a potential target for additional biologic therapies. Monoclonal antibodies targeting IL-12/23 have shown efficacy in animal models of colitis, and are currently being studied in Phase III clinical trials of CD. This review focuses on ustekinumab, a fully human immunoglobulin G1 monoclonal antibody, which blocks activity of IL-12 and IL-23 through binding the p40 subunit, and describes the current efficacy and safety data for ustekinumab in patients with CD.
Cerebral Venous Thrombosis (1999)

Our experience with intrathrombus rtPA in conjunction with intravenous heparin in patients with CVT is encouraging. This therapy should probably be regarded as unsafe in patients with obvious hemorrhage. Time to restore flow may be faster than with urokinase (an average of 71 hours has been reported for 29 documented patients). Further evaluation of rtPA with heparin in CVT is warranted.
Counting YouTube videos via random prefix sampling (2011)

Leveraging the characteristics of YouTube video id space and exploiting a unique property of YouTube search API, in this paper we develop a random prefix sampling method to estimate the total number of videos hosted by YouTube. Through theoretical modeling and analysis, we demonstrate that the estimator based on this method is unbiased, and provide bounds on its variance and confidence interval. These bounds enable us to judiciously select sample sizes to control estimation errors. We evaluate our sampling method and validate the sampling results using two distinct collections of YouTube video id's (namely, treating each collection as if it were the "true" collection of YouTube videos). We then apply our sampling method to the live YouTube system, and estimate that there are a total of roughly 500 millions YouTube videos by May, 2011. Finally, using an unbiased collection of YouTube videos sampled by our method, we show that YouTube video view count statistics collected by prior methods (e.g., through crawling of related video links) are highly skewed, significantly under-estimating the number of videos with very small view counts (<1000); we also shed lights on the bounds for the total storage YouTube must have and the network capacity needed to delivery YouTube videos.
1 ,3-Dipolar Character of 6-Membered Aromatic Rings. Part XXXVII. Mass Spectrometry of Diazinium Betaines (1978)

School of Chemical Sciences, University of East Anglia, Norwich NR4 7TJ, England Diazinium betaines evaporate as mesoions rather than undergoing valence tautomerism. The fragmentation patterns are elucidated by metastable peaks and precise mass measurements and discussed.
General Synthesis of Persistent Trityl Radicals for EPR Imaging of Biological Systems (2002)

In this paper we describe the syntheses of the tetraoxygenated triarylmethyl (trityl) radical 14 and the tetrathiatriarylmethyl (trityl) radicals 15 and 16. The syntheses include new and improved preparations of the key intermediate compounds 1 and 2. The new route to compound 2 is noteworthy for its efficiency and its avoidance of the highly toxic compound phosgene as well as the isolation of the air-sensitive 1,2,4,5-benzenetetrathiol.
Towards Structural Determination of the Water-splitting Enzyme (2000)

A photosystem II preparation from the thermophilic cyanobacterium Synechococcus elongatus, which is especially suitable for three-dimensional crystallization in a fully active form was developed. The efficient purification method applied here yielded 10 mg of protein of a homogenous dimeric complex of about 500 kDa within 2 days. Detailed characterization of the preparation demonstrated a fully active electron transport chain from the manganese cluster to plastoquinone in the Q(B) binding site. The oxygen-evolving activity, 5000-6000 micromol of O(2)/(h.mg of chlorophyll), was the highest so far reported and is maintained even at temperatures as high as 50 degrees C. The crystals obtained by the vapor diffusion method diffracted to a resolution of 4.3 A. The space group was determined to be P2(1)2(1)2(1) with four photosystem II dimers per unit cell. Analysis of the redissolved crystals revealed that activity, supramolecular organization, and subunit composition were maintained during crystallization.
Skin Hardness and Epidermal Thickness Affect the Vibration Sensitivity of the Foot Sole (2017)

Objective: The cutaneous mechanoreceptors of the foot sole detect the changes in the application of mechanical loads on the plantar surface during gait and standing, and contribute to controlling the standing balance and postural reflexes in healthy subjects. A local thickening of the foot sole skin occurs in response to repetitive load application. We hypothesized that an elevated skin hardness of the foot sole could reduce its mechano sensitivity. Methods: In healthy subjects, we quantified the sensation produced by different amplitudes of vibratory stimulations at two frequencies (25 and 150 Hz). The vibration threshold was determined on the 1st or 2nd, and 5th metatarsal heads, and the heel at each vibration frequency. The Stevens power function (Ψ=k.Φn) allowed to obtain regression equations between the estimate (Ψ) of the vibratory stimuli and their physical magnitude (Φ). Any increase in the absolute k value (all were negative) indicated a reduced sensitivity to the lowest loads. The n coefficient measured the global perception. The highest skin hardness (Shore) was measured on the 5th metatarsal head and the heel. In some subjects, superficial skin abrasion of the 5th metatarsal head was performed and the vibration sensitivity was tested again. Results: The vibration threshold was significantly higher at the level of the 5th metatarsal head and the heel. The k value was significantly higher at the 25 and 150 Hz frequencies for the 5th metatarsal head, and only at 25 Hz for the heel. At both vibration frequencies, negative correlations were obtained between the k values and skin hardness. After skin abrasion, the n coefficient was significantly higher at both vibration frequencies. Conclusion: Skin hardness affects the foot sole mechano sensitivity and could alter the control of posture during standing and walking. This indicates that foot care by podiatrist are relevant to improve posture control.
Investigation on the effect of health education on compliance of rural patients with epileptics (2010)

Objective To explore the effect of health education on compliance of rural patients with epileptics in Heilongjiang Province.Methods A total of 318 patients with epileptics were randomly divided into two groups:study group and control group.The control group performed routine education while the study group performed organized health education of epileptics after the first following-up.The effect of education intervention was compared between two groups after 6 months.Results There was no significant difference in the scores of compliance between two groups at the first following-up (P＞ 0.05).However,the score of compliance in study group was obviously higher than that in the control group at the second following-up (P< 0.05).Conclusions Health education can improve the compliance of epilepsy and reduce the attack rate and the occurrence of complications such as trauma or infection.

Key words: 
Health education; Patient compliance; Epilepsy
The Chemical Interplay between Nitric Oxide and Mitochondrial Cytochrome<i>c</i>Oxidase: Reactions, Effectors and Pathophysiology (2012)

Nitric oxide (NO) reacts with Complex I and cytochrome c oxidase (CcOX, Complex IV), inducing detrimental or cytoprotective effects. Two alternative reaction pathways (PWs) have been described whereby NO reacts with CcOX, producing either a relatively labile nitrite-bound derivative (CcOX-NO(2) (-), PW1) or a more stable nitrosyl-derivative (CcOX-NO, PW2). The two derivatives are both inhibited, displaying different persistency and O(2) competitiveness. In the mitochondrion, during turnover with O(2), one pathway prevails over the other one depending on NO, cytochrome c(2+) and O(2) concentration. High cytochrome c(2+), and low O(2) proved to be crucial in favoring CcOX nitrosylation, whereas under-standard cell-culture conditions formation of the nitrite derivative prevails. All together, these findings suggest that NO can modulate physiologically the mitochondrial respiratory/OXPHOS efficiency, eventually being converted to nitrite by CcOX, without cell detrimental effects. It is worthy to point out that nitrite, far from being a simple oxidation byproduct, represents a source of NO particularly important in view of the NO cell homeostasis, the NO production depends on the NO synthases whose activity is controlled by different stimuli/effectors; relevant to its bioavailability, NO is also produced by recycling cell/body nitrite. Bioenergetic parameters, such as mitochondrial ΔΨ, lactate, and ATP production, have been assayed in several cell lines, in the presence of endogenous or exogenous NO and the evidence collected suggests a crucial interplay between CcOX and NO with important energetic implications.
<i>In vivo</i>proton range verification: a review (2013)

Protons are an interesting modality for radiotherapy because of their well defined range and favourable depth dose characteristics. On the other hand, these same characteristics lead to added uncertainties in their delivery. This is particularly the case at the distal end of proton dose distributions, where the dose gradient can be extremely steep. In practice however, this gradient is rarely used to spare critical normal tissues due to such worries about its exact position in the patient. Reasons for this uncertainty are inaccuracies and non-uniqueness of the calibration from CT Hounsfield units to proton stopping powers, imaging artefacts (e.g. due to metal implants) and anatomical changes of the patient during treatment. In order to improve the precision of proton therapy therefore, it would be extremely desirable to verify proton range in vivo, either prior to, during, or after therapy. In this review, we describe and compare state-of-the art in vivo proton range verification methods currently being proposed, developed or clinically implemented.
Mucosal Bacterial Immunotherapy in Solid Organ Recipients with Recurrent Respiratory Tract Infections: Case Report (2020)

Bacterial infections are the most frequent infectious complications among solid organ recipients. These complications are associated with a high morbidity and mortality, despite recent advances in antimicrobial prophylaxis in the transplant setting. New therapeutic modalities are warranted. We present here a retrospective study based on medical records review of 2 solid organ recipients that were treated with mucosal bacterial immunotherapy because of recurrent bacterial respiratory infections long time after transplantation. A successful decrease of the frequency of bacterial respiratory infections during a period of up to 8 years was observed in one of the patients. We suggest that clinical trials in this field are warranted.
Antimicrobial Evaluation of Nocathiacins, a Thiazole Peptide Class of Antibiotics (2004)

Nocathiacins are cyclic thiazolyl peptides with inhibitory activity against gram-positive bacteria. BMS-249524 (nocathiacin I), identified from screening a library of compounds against a multiply antibiotic-resistant Enterococcus faecium strain, was used as a lead chemotype to obtain additional structurally related compounds. The MIC assay results of BMS-249524 and two more water-soluble derivatives, BMS-411886 and BMS-461996, revealed potent in vitro activities against a variety of gram-positive pathogens including methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, vancomycin intermediate-resistant S. aureus, vancomycin-resistant enterococci, Mycobacterium tuberculosis and Mycobacterium avium. Analysis of killing kinetics revealed that these compounds are bactericidal for S. aureus with at least a 3-log(10) reduction of bacterial growth within 6 h of exposure to four times the MICs. Nocathiacin-resistant mutants were characterized by DNA sequence analyses. The mutations mapped to the rplK gene encoding the L11 ribosomal protein in the 50S subunit in a region previously shown to be involved in the binding of related thiazolyl peptide antibiotics. These compounds demonstrated potential for further development as a new class of antibacterial agents with activity against key antibiotic-resistant gram-positive bacterial pathogens.
Dearomatization and Functionalization of Terpyridine by Lutetium(III) Alkyl Complexes (2006)

Lutetium(III)-bis(alkyl) and -tris(alkyl) fragments supported by either 2,2':6',2' '-terpyridine or 4,4',4' '-tri-tert-butyl-2,2':6',2' '-terpyridine are not stable and undergo facile 1,3-alkyl migration under ambient conditions resulting in dearomatization and ortho (2' or 6') functionalization of the terpyridyl ligand, clearly demonstrating that the terpyridyl ligand framework is not as innocent as previously thought.
Sensitivity minimization of digital controllers via frequency-weighted balancing (1991)

The analysis and minimization of the coefficient sensitivity of digital controllers which are represented by state equations are conducted. The frequency-independent sensitivity of controllers is represented by the frequency-weighted controllability Gramian and the frequency-weighted observability Gramian of controllers. The minimum sensitivity controller is synthesized by using an equivalent transformation matrix. The sensitivity of a controller is minimum if it has the frequency-weighted balanced realization with scalar scaling.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The C1473G polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain (2007)

Brain neurotransmitter serotonin is involved in the regulation of many physiological functions and types of behavior. The key enzyme of serotonin synthesis in the brain is tryptophan hydroxylase-2 (TPH-2). An association of the C1473G polymorphism in gene tph2 causing the replacement of Pro447 by Arg447 in TPH-2 molecule with enzyme activity in the mouse brain of 10 inbred strains was found. Association of the polymorphism with the TPH-2 activity in the brain of F2 hybrids between strains C57BL/6 and CC57BR was shown. The results indicate that the C1473G polymorphism in gene tph2 is the main factor determining the genetic defined variability of enzyme activity in the mouse brain.