gebhart/patrepeval huggingface dataset:
An Intelligent System Framework For Generating Activity List Of A Project Using Wbs Mind Map And Semantic Network (2008)

Work Breakdown Structure (WBS) is one of the most vital planning processes of the project management since it is considered to be the fundamental of other processes like scheduling, controlling, assigning responsibilities, etc. In fact WBS or activity list is the heart of a project and omission of a simple task can lead to an irrecoverable result. There are some tools in order to generate a project WBS. One of the most powerful tools is mind mapping which is the basis of this article. Mind map is a method for thinking together and helps a project manager to stimulate the mind of project team members to generate project WBS. Here we try to generate a WBS of a sample project involving with the building construction using the aid of mind map and the artificial intelligence (AI) programming language. Since mind map structure can not represent data in a computerized way, we convert it to a semantic network which can be used by the computer and then extract the final WBS from the semantic network by the prolog programming language. This method will result a comprehensive WBS and decrease the probability of omitting project tasks.
The ergonomic design of workstations using virtual manufacturing and response surface methodology (2002)

Abstract The increasing use of computerized tools for virtual manufacturing in workstatin design has two main advantages over traditional methods first it enables the designer to examine a large number of design solutions; and second, simulation of the work task may be performedin order to obtain the values of various performance measures. In this paper a ne~ structural. methodology for the workstation design is presented. Factorial experiments and the response surface methodology are integrated 111 order to reduce the number of examined design solutions and obtain an estimate for the best design configuration With respect to multi-objective requirements.
New Metal Salt-Induced Homolytic Reactions. II. Modification of Free Radical Reactions by Copper Salts<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Metal Salt-Induced Homolytic Reactions. II. Modification of Free Radical Reactions by Copper Salts1M. S. KHARASCH and ANDREW FONOCite this: J. Org. Chem. 1959, 24, 5, 606–614Publication Date (Print):May 1, 1959Publication History Published online1 May 2002Published inissue 1 May 1959https://pubs.acs.org/doi/10.1021/jo01087a007https://doi.org/10.1021/jo01087a007research-articleACS PublicationsRequest reuse permissionsArticle Views308Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improving the application development process with modular visualization environments (1995)

Modular Visualization Environments (MVE) such as the Application Visualization System (AVS TM) are well known in scientific and engineering communities as powerful tools for the visualization and analysis of technical data.More recently, tools such as AVS are gaining broader acceptance for general purpose application development.We believe that in order for MVEs to be successful visualization environments, they must first be good application development systems.This paper will discuss the strengths and weaknesses of Modular Visualization Environments in certain aspects of the application development process.
Polymer Wire Chemical Sensor Using a Microfabricated Tuning Fork (2003)

We have measured the mechanical properties of a polymer wire bridged across the two prongs of a microfabricated tuning fork. The polymer wire is formed by stretching so that it has a built-in mechanical stress. Upon exposure to organic vapors, the stress in the polymer wire diminishes, which is sensitively detected from the changes in the resonance of the tuning fork. We have also shown that by trimming the polymer wire from micrometers down to nanometers the sensitivity and response improve considerably because of an increased surface-to-volume ratio and sharper resonance of the polymer wire-tuning fork system.
Substrate Recognition of MARTX Ras/Rap1-Specific Endopeptidase (2017)

Ras/Rap1-specific endopeptidase (RRSP) is a cytotoxic effector domain of the multifunctional autoprocessing repeats-in-toxin (MARTX) toxin of highly virulent strains of Vibrio vulnificus. RRSP blocks RAS-MAPK kinase signaling by cleaving Ras and Rap1 within the switch I region between Y32 and D33. Although the RRSP processing site is highly conserved among small GTPases, only Ras and Rap1 have been identified as proteolytic substrates. Here we report that residues Y32 and D33 at the scissile bond play an important role in RRSP substrate recognition, while the nucleotide state of Ras has an only minimal effect. In addition, substrate specificity is generated by residues across the entire switch I region. Indeed, swapping the Ras switch I region into either RalA or RhoA, GTPases that are not recognized by RRSP, generated chimeras that are substrates of RRSP. However, a difference in the processing efficiency of Ras switch I in the context of Ras, RalA, or RhoA indicates that protein regions outside Ras switch I also contribute to efficient RRSP substrate recognition. Moreover, we show that synthetic peptides corresponding to the Ras and Rap1, but not RalA, switch I regions are cleaved by RRSP, demonstrating sequence-specific substrate recognition. In conclusion, this work demonstrates that the GTPase recognition of RRSP is independent of the nucleotide state and is mainly driven by the Ras and Rap1 switch I loop and also influenced by additional protein-protein interactions, increasing the substrate specificity of RRSP.
Cancer immunotherapy via combining oncolytic virotherapy with chemotherapy: recent advances (2016)

Oncolytic viruses are multifunctional anticancer agents with huge clinical potential, and have recently passed the randomized Phase III clinical trial hurdle. Both wild-type and engineered viruses have been selected for targeting of specific cancers, to elicit cytotoxicity, and also to generate antitumor immunity. Single-agent oncolytic virotherapy treatments have resulted in modest effects in the clinic. There is increasing interest in their combination with cytotoxic agents, radiotherapy and immune-checkpoint inhibitors. Similarly to oncolytic viruses, the benefits of chemotherapeutic agents may be that they induce systemic antitumor immunity through the induction of immunogenic cell death of cancer cells. Combining these two treatment modalities has to date resulted in significant potential in vitro and in vivo synergies through various mechanisms without any apparent additional toxicities. Chemotherapy has been and will continue to be integral to the management of advanced cancers. This review therefore focuses on the potential for a number of common cytotoxic agents to be combined with clinically relevant oncolytic viruses. In many cases, this combined approach has already advanced to the clinical trial arena.
Greener Nanoscience: A Proactive Approach to Advancing Applications and Reducing Implications of Nanotechnology (2008)

Nanotechnology continues to offer new materials and applications that will benefit society, yet there is growing concern about the potential health and environmental impacts of production and use of nanoscale products. Although hundreds of studies of nanomaterial hazards have been reported, due (largely) to the complexity of the nanomaterials, there is no consensus about the impact these hazards will have. This Focus describes the need for a research agenda that addresses these nanomaterial complexities through coordinated research on the applications and implications of new materials, wherein nanomaterials scientists play a central role as we move from understanding to minimizing nanomaterial hazards. Greener nanoscience is presented as an approach to determining and implementing the design rules for safer nanomaterials and safer, more efficient processes.
Potential Drifts of Solid-Contacted Ion-Selective Electrodes Due to Zero-Current Ion Fluxes Through the Sensor Membrane (2000)

A thin aqueous layer is formed between the polymeric ion-selective membrane and an inner gold electrode. Its composition can be altered upon sample changes, which leads to drifting potentials. It is shown by theory and experiment that interfering ions enter the inner layer much faster than primary ones. Measurement protocols with equal contact times for the sample and the reconditioning solution can therefore not eliminate the effect of changes in the composition of the inner solution. The formation of an inner aqueous film and corresponding drifts for solid-contacted membrane electrodes can be avoided by creating a lipophilic self-assembled monolayer on the surface of the inner electrode.
Improvement of mass transport of the [Co(bpy)3]II/III redox couple by controlling nanostructure of TiO2 films in dye-sensitized solar cells (2011)

Mass transport of the [Co(bpy)(3)](II/III) redox electrolyte is found to strongly depend on porosity and pore size of mesoporous TiO(2) films. Photocurrent density is improved by nearly two times with increasing the porosity from 0.52 to 0.59 despite 23% decreased dye loading. Optimized nanostructure sensitized with MK-2 dye shows efficiency of 5.5% at 1 sun.
Design of a Fault-Tolerant Controller Based on Observers for a PMSM Drive (2011)

This paper presents a specific controller architecture devoted to obtain a permanent-magnet synchronous motor (PMSM) drive that is robust to mechanical sensor failure. In order to increase the reliability which is a key issue in industrial and transportation applications (electric or hybrid ground vehicle or aerospace actuators), two virtual sensors (a two-stage extended Kalman filter and a back-electromotive-force adaptive observer) and a maximum-likelihood voting algorithm are combined with the actual sensor to build a fault-tolerant controller (FTC). The observers are evaluated through simulation and experimental results. The FTC feasibility is proved through simulations and experiments on a 1.1-kW PMSM drive.
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking (2011)

Intramembrane proteolysis is a conserved mechanism that regulates a variety of cellular processes ranging from transcription control to signaling. In mitochondria, the inner membrane rhomboid protease PARL has been implicated in the control of life span and apoptosis by a so far uncharacterized mechanism. Here, we show that PARL cleaves human Pink1, which is implicated in Parkinson's disease, within its conserved membrane anchor. Mature Pink1 is then free to be released into the cytosol or the mitochondrial intermembrane space. Upon depolarization of the mitochondrial membrane potential, the canonical import of Pink1 and PARL-catalyzed processing is blocked, leading to accumulation of the Pink1 precursor. As targeting of this precursor to the outer mitochondrial membrane has been shown to trigger mitophagy, we suggest that the PARL-catalyzed removal of the Pink1 signal sequence in the canonical import pathway acts as a cellular checkpoint for mitochondrial integrity. Furthermore, we show that two Parkinson's disease-causing mutations decrease the processing of Pink1 by PARL, with attendant implications for pathogenesis.
Integration of Performance Measurement and Modeling for Open Distributed Processing (1995)

Successful deployment of open distributed processing requires integrated performance management facilities. This paper describes measurement and modeling technologies that provide quality of service (QoS) measures and projections for distributed applications. The vital role of performance instrumentation and modeling is applied to the Reference Model for Open Distributed Processing. We discuss an architecture and prototype for an efficient measurement infrastructure for heterogeneous distributed environments. We present an application model useful for application design, deployment and capacity planning. We demonstrate that integrated measurement and modeling yields the QoS measures that guide application deployment and increase management capability.
HomeRF and Bluetooth: A Wireless Data Communications Revolution in the Making (1999)

This contains presentations slides on the wireless data communications industry and its future development.
Integrating Autonomous Behavior and User Control for Believable Agents (2004)

Autonomous agents can help users by taking on a substantial workload, and performing tasks that are too complex for a human. However, in some systems complete autonomy is undesirable as it removes control from the user. It is therefore important to include some user control while maintaining the reduced workload associated with an autonomous system. This is particularly true of user avatars in virtual worlds, appropriate non-verbal communication is too complex to be directed explicitly and should therefore be controlled by an agent. However, the non-verbal communication should express the feelings of the user, so a degree of human input is needed. This paper presents Demeanour, an autonomous system for generating body language in avatars, which integrates user input based on a three level methodology of customization and control.
The Risk Taken in Crossing a Road (1955)

(1955). The Risk Taken in Crossing a Road. Journal of the Operational Research Society: Vol. 6, No. 3, pp. 120-128.
Active current management for four-rail railguns (1991)

A system of auxiliary conductors designed to reduce current density peaks in railgun rails for four-rail, round-bore railguns is described. The effects on rail current density and projectile force are discussed. Railgun cross-sectional designs are presented for round-bore, four-rail railguns which operate at lower peak current densities and develop greater projectile forces than conventional two-rail, round-bore railguns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Fourier Domain Common-Path Fiber OCT with Tunable Reference: Analysis and Optimization (2007)

We have built a Fourier domain, fiber-optic, common-path OCT system with a tunable reference. We report our initial investigation of the performance of the system and analyze the results.
A Governance Model for SOA (2009)

Currently, business requirements for rapid operational efficiency, customer responsiveness as well as rapid adaptability are driving the need for ever increasing communication and integration capabilities of the software assets. Service Oriented Architecture (SOA) is generally acknowledged as being a potential solution to expose finely grained pieces of software components on a network that are reusable and composable. Provisioning of business services for different business purposes may require the rapid assembly of their core functionality with different infrastructure capabilities and policies in different contexts. In this paper, the authors propose a SOA based governance model that permits to handle non functional requirements in a dynamic way.
Biochemical and Pharmacological Analyses of HIV-1 Integrase Flexible Loop Mutants Resistant to Raltegravir (2010)

Resistance to raltegravir (RAL), the first HIV-1 integrase (IN) inhibitor approved by the FDA, involves three genetic pathways: IN mutations N155H, Q148H/R/K, and Y143H/R/C. Those mutations are generally associated with secondary point mutations. The resulting mutant viruses show a high degree of resistance against RAL but somehow are affected in their replication capacity. Clinical and virological data indicate the high relevance of the combination G140S + Q148H because of its limited impact on HIV replication and very high resistance to RAL. Here, we report how mutations at the amino acid residues 140, 148, and 155 affect IN enzymatic activity and RAL resistance. We show that single mutations at position 140 have limited impact on 3'-processing (3'-P) but severely inactivate strand transfer (ST). On the other hand, single mutations at position 148 have a more profound effect and inactivate both 3'-P and ST. By examining systematically all of the double mutants at the 140 and 148 positions, we demonstrate that only the combination G140S + Q148H is able to restore the catalytic properties of IN. This rescue only operates in cis when both the 140S and 148H mutations are in the same IN polypeptide flexible loop. Finally, we show that the G140S-Q148H double mutant exhibits the highest resistance to RAL. It also confers cross-resistance to elvitegravir but less to G-quadraduplex inhibitors such as zintevir. Our results demonstrate that IN mutations at positions 140 and 148 in the IN flexible loop can account for the phenotype of RAL-resistant viruses.
Protective Effects of Standardized Pomegranate (<i>Punica granatum</i> L.) Polyphenolic Extract in Ultraviolet-Irradiated Human Skin Fibroblasts (2008)

Exposure to ultraviolet (UV) radiation has been associated with several acute and chronic conditions, including sunburn, edema, hyperplasia, immunosuppression, photoaging, and skin cancer. The role of naturally occurring phytochemicals in the prevention of such UV-related conditions has captured increased interest. Pomegranate ( Punica granatum L.) is a rich source of polyphenolics, which have been shown to exert anti-inflammatory, antioxidant, and anticarcinogenic activity in numerous in vivo and in vitro studies. This work investigated potential protective effects of a pomegranate fruit extract standardized to punicalagins against UVA- and UVB-induced damage in SKU-1064 human skin fibroblast cells. Pomegranate extract (PE), in a range from 5 to 60 mg/L, was effective at protecting human skin fibroblasts from cell death following UV exposure, likely related to a reduced activation of the pro-inflammatory transcription factor NF-kappaB, a downregulation of proapoptotic caspase-3, and an increased G0/G1 phase, associated with DNA repair. Higher polyphenolic concentrations (500-10000 mg/L) were needed to achieve a significant reduction in UV-induced reactive oxygen species levels and increased intracellular antioxidant capacity (from 1.9 to 8.6 muM Trolox equivalents/mL). Results from this study demonstrate the protective effects of PE against UVA- and UVB-induced cell damage and the potential use of pomegranate polyphenolics in topical applications.
Significance tests based on residuals (1971)

The known distribution of residuals from linear regression models may be used to construct exact tests of significance. New tests for the presence of one or more outliers are considered in detail. Applications of the theory to other tests are discussed. Exact results are worked out for the normal and exponential error distributions; formulae are given for other nonnormal cases.
Interaction of<i>Bordetella bronchiseptica</i>and Its Lipopolysaccharide with<i>In Vitro</i>Culture of Respiratory Nasal Epithelium (2013)

The nasal septa of fetal rabbits at 26 days of gestation were harvested by cesarean section of the does while under anesthesia and then exposed to Bordetella bronchiseptica or its lipopolysaccharide (LPS) for periods of 2 and 4 hours. A total of 240 explants were used. The tissues were examined using the Hematoxylin & Eosin technique. Then, semithin sections (0.5 μm) were stained with toluidine blue and examined with indirect immunoperoxidase (IPI) and lectin histochemistry. The most frequent and statistically significant findings were as follows: (1) cell death and increased goblet cell activity when exposed to bacteria and (2) cell death, cytoplasmic vacuolation and infiltration of polymorphonuclear leukocytes when exposed to LPS. The lesions induced by the bacterium were more severe than with LPS alone, except for the cytoplasmic vacuolation in epithelial cells. IPI stained the ciliated border of the epithelium with the bacterium more intensely, while LPS lectin histochemistry preferentially labeled the cytoplasm of goblet cell. These data indicate that B. bronchiseptica and its LPS may have an affinity for specific glycoproteins that would act as adhesion receptors in both locations.
Online Fluorescence Suppression in Modulated Raman Spectroscopy (2009)

Label-free chemical characterization of single cells is an important aim for biomedical research. Standard Raman spectroscopy provides intrinsic biochemical markers for noninvasive analysis of biological samples but is often hindered by the presence of fluorescence background. In this paper, we present an innovative modulated Raman spectroscopy technique to filter out the Raman spectra from the fluorescence background. The method is based on the principle that the fluorescence background does not change whereas the Raman scattering is shifted by the periodical modulation of the laser wavelength. Exploiting this physical property and importantly the multichannel lock-in detection of the Raman signal, the modulation technique fulfills the requirements of an effective fluorescence subtraction method. Indeed, once the synchronization and calibration procedure is performed, minimal user intervention is required, making the method online and less time-consuming than the other fluorescent suppression methods. We analyze the modulated Raman signal and shifted excitation Raman difference spectroscopy (SERDS) signal of 2 mum-sized polystyrene beads suspended in a solution of fluorescent dye as a function of modulation rate. We show that the signal-to-noise ratio of the modulated Raman spectra at the highest modulation rate is 3 times higher than the SERDS one. To finally evaluate the real benefits of the modulated Raman spectroscopy, we apply our technique to Chinese hamster ovary cells (CHO). Specifically, by analyzing separate spectra from the membrane, cytoplasm, and nucleus of CHO cells, we demonstrate the ability of this method to obtain localized sensitive chemical information from cells, away from the interfering fluorescence background. In particular, statistical analysis of the Raman data and classification using PCA (principal component analysis) indicate that our method allows us to distinguish between different cell locations with higher sensitivity and specificity, avoiding potential misinterpretation of the data obtained using standard background procedures.
GONZALEZ MARTIN: MARXISMO Y CIENCIAS DEL PSIQUISMO. (1998)

The article presents a brief overview of the life and work of Doctor Diego Gonzalez Martin, the first man in Cuba to approach psychism sciences (psychiatric, psychology and neurophysiology) from a Marxist perspective.
Efficacy of recombinant soluble thrombomodulin in disseminated intravascular coagulation associated with sepsis (2011)

s and Programme: EUROANAESTHESIA 2011: The European Anaesthesiology Congress: Intensive Care Medicine