gebhart/patrepeval huggingface dataset:
The Protective Effect of N‐Acetylcysteine on UVB‐Induced Immunosuppression by Inhibition of the Action of Cis‐Urocanic Acid (1996)

A recent study has shown that N-acetylcysteine (NAC) not only has sun-protective properties but also inhibits the UVB-induced suppression of contact hypersensitivity (CHS) in mice. Because NAC does not absorb any UVA (320-400 nm radiation) or UVB (290-320 nm radiation) we have studied the underlying mechanism of protection. Irradiation of solutions of plasmid DNA with UVC (200-290 nm radiation) (10 J m-2) resulted in the formation of cyclobutane pyrimidine dimers, but the extent to which this occurred was not affected by the presence of NAC as was determined by an in vitro T4 endonuclease assay. N-acetylcysteine proved not to have any effect on the photoisomerization of trans-urocanic acid (UCA) to its cis-form in vitro; at equilibrium, approximately 55% cis-UCA was formed. The same percentage was also found in vivo on exposure of mice to UVB (15 kJ m-2). Topical application of NAC 30 min prior to irradiation did not have any influence as well on the photoisomerization of trans- to cis-UCA. These in vivo experiments were performed under the same conditions used previously to show the protective effect of NAC against UVB-induced suppression of CHS. We conclude that this protection of NAC is at least partly based on interference in the role of cis-UCA in UVB-induced suppression of CHS. This conclusion is supported by the observation that NAC completely inhibits the suppression of CHS by cis-UCA administered to mice that were always kept in the dark. In the same range of doses as used in the present study, it was shown in our previous study that NAC alone does not affect the CHS response.
Herstel van bosecosystemen via nutriënten-giften en ingrepen in het bomenbestand: een succes? Effectgerichte maatregelen in multifunctionele bossen geëvalueerd (2006)

Sinds 1995 worden er in het kader van het overlevingsplan bos en natuur (obn) met subsidie effectgerichte maatregelen (EGM) uitgevoerd in Nederlandse multifunctionele bossen. Deze maatregelen dienen als overbrugging naar een periode met minder verzuring, vermesting en verdroging. Alterra en Eelerwoude voerden in opdracht van LNV Directie Kennis een uitgebreid evaluatieonderzoek uit naar de effecten van deze maatregel. In dit artikel de opmerkelijkste resultaten plus het beleidsadvies aan LNV dat het OBN Deskundigenteam Bossen gaf (het belangrijkste daaruit: bemesten en bekalken van bos is niet effectief). Zie ook de 9 deelrapporten van Alterra (no. 1337)
Determination of free hydrogen cyanide in river water by a solvent-extraction method (1969)

The method described for the determination of undissociated hydrogen cyanide in river waters is designed to avoid disturbance of the equilibria between hydrogen cyanide, cyanide ion and complex cyanides during the determination. A small proportion of the hydrogen cyanide present is extracted by equilibrating the sample with 1,1,1-trichloroethane. The extracted hydrogen cyanide is then transferred into sodium pyrophosphate solution, and the determination is completed colorimetrically by a modification of the method of Bark and Higson. The effect of temperature on the extraction has been studied. Extractions can be carried out in the field, and conditions have been established for bringing extracted samples back to the laboratory for colorimetric analysis. The method can be used in the range 0 to 2 mg of hydrogen cyanide l–1 and less than 0·01 mg l–1 is detectable. Satisfactory tests have been carried out on solutions of known hydrogen cyanide content, on solutions of metallic complex cyanides and on river waters containing added cyanide.
Thermal decomposition behavior of bis‐aminimides and their application to polymerization of epoxide (1987)

Abstract Bis‐aminimide compounds [bis‐ N , N ,‐dimethyl‐ N ,‐(2‐hydroxypropyl)‐amine‐ N ,′‐adipimide ( 1 ) and bis‐trimethylamine adipimide ( 2 )] were found to exhibit different thermal decomposition behavior and polymerization efficiency for an epoxide (phenyl glycidyl ether, PGE). The thermal decomposition rate of 1 was much higher than that of 2. It seemed that hydrogen bonding enhanced the decomposition rate. Compound 1 was thermolyzed to give a diisocyanate and a tertiary aminoalcohol, which subsequently reacted with each other to give a urethane. When 2 was heated, the isocyanate generated from 2 remained unreacted. PGE reacted with thoseaminimides to give different products, depending on their thermolyzed products. Mixtures of diisocyanate, tertiary amine, and PGE were used in the model reactions, and the thermal reaction between the expected decomposition products of aminimides was investigated in the presence and absence of PGE. The amount of high molecular weight fraction in PGE + 2 is greater than that of PGE + 1 . In the former, the free isocyanate groups may act as a chain extender to give higher molecular weight fractions.
On Simultaneous Confidence Intervals for Multinomial Proportions (1965)

In this article we present a method for obtaining simultaneous confidence intervals for the parameters of a multinomial distribution, and we compare this method with the one suggested recently by Quesenberry and Hurst (1964). For the usual probability levels, we find, for example, that the confidence intervals introduced here have the desirable property that they are shorter than the corresponding intervals obtained by the Quesenberry-Hurst method. We also present methods for obtaining simultaneous confidence intervals for the differences among the parameters of the multinomial distribution, and we compare these methods with the one suggested earlier by Gold (1963) for studying linear functions of the multinomial parameters. For the usual probability levels, we find that the confidence intervals introduced in the present article have the desirable property that they are shorter than the corresponding intervals obtained by the Gold method applied to the differences among the multinomial parameters. In addition, we show how the methods presented here for studying the differences among the multinomial parameters can be modified in order to obtain simultaneous confidence intervals for the relative differences among the multinomial parameters.
Fanconi Anemia Proteins FANCA, FANCC, and FANCG/XRCC9 Interact in a Functional Nuclear Complex (1999)

Fanconi anemia (FA) is an autosomal recessive cancer susceptibility syndrome with at least eight complementation groups (A to H). Three FA genes, corresponding to complementation groups A, C, and G, have been cloned, but their cellular function remains unknown. We have previously demonstrated that the FANCA and FANCC proteins interact and form a nuclear complex in normal cells, suggesting that the proteins cooperate in a nuclear function. In this report, we demonstrate that the recently cloned FANCG/XRCC9 protein is required for binding of the FANCA and FANCC proteins. Moreover, the FANCG protein is a component of a nuclear protein complex containing FANCA and FANCC. The amino-terminal region of the FANCA protein is required for FANCG binding, FANCC binding, nuclear localization, and functional activity of the complex. Our results demonstrate that the three cloned FA proteins cooperate in a large multisubunit complex. Disruption of this complex results in the specific cellular and clinical phenotype common to most FA complementation groups.
Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine’s Antidepressant Effect—Reply (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
MARVLE: a VLSI chip for variable length encoding and decoding (2003)

The design and implementation of a CMOS VLSI chip for data compression and decompression, using tree-based codes are described. The chip, called MARVLE, implements a memory-based architecture, for variable length encoding and decoding based on tree-based codes. The chip implements an architecture that is based on an efficient scheme for mapping the tree representing any binary code onto a memory device. A prototype 2- mu m chip has been designed and verified, and fabricated by MOSIS. The chip can yield a compression rate of 57 Mb/s and a decompression rate of 31 Mb/s with a clock rate of 50 MHz. The VLSI hardware can be used to implement the JPEG baseline compression scheme.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Golden Egg: Nutritional Value, Bioactivities, and Emerging Benefits for Human Health (2019)

Egg is an encapsulated source of macro and micronutrients that meet all requirements to support embryonic development until hatching. The perfect balance and diversity in its nutrients along with its high digestibility and its affordable price has put the egg in the spotlight as a basic food for humans. However, egg still has to face many years of nutritionist recommendations aiming at restricting egg consumption to limit cardiovascular diseases incidence. Most experimental, clinical, and epidemiologic studies concluded that there was no evidence of a correlation between dietary cholesterol brought by eggs and an increase in plasma total-cholesterol. Egg remains a food product of high nutritional quality for adults including elderly people and children and is extensively consumed worldwide. In parallel, there is compelling evidence that egg also contains many and still-unexplored bioactive compounds, which may be of high interest in preventing/curing diseases. This review will give an overview of (1) the main nutritional characteristics of chicken egg, (2) emerging data related to egg bioactive compounds, and (3) some factors affecting egg composition including a comparison of nutritional value between eggs from various domestic species.
PBP2a Mutations Causing High-Level Ceftaroline Resistance in Clinical Methicillin-Resistant Staphylococcus aureus Isolates (2014)

Ceftaroline is the first member of a novel class of cephalosporins approved for use in the United States. Although prior studies have identified eight ceftaroline-resistant methicillin-resistant Staphylococcus aureus (MRSA) isolates in Europe and Asia with MICs ranging from 4 to 8 mg/liter, high-level resistance to ceftaroline (>32 mg/liter) has not been described in MRSA strains isolated in the United States. We isolated a ceftaroline-resistant (MIC > 32 mg/liter) MRSA strain from the blood of a cystic fibrosis patient and five MRSA strains from the respiratory tract of this patient. Whole-genome sequencing identified two amino acid-altering mutations uniquely present in the ceftaroline-binding pocket of the transpeptidase region of penicillin-binding protein 2a (PBP2a) in ceftaroline-resistant isolates. Biochemical analyses and the study of isogenic mutant strains confirmed that these changes caused ceftaroline resistance. Thus, we identified the molecular mechanism of ceftaroline resistance in the first MRSA strain with high-level ceftaroline resistance isolated in the United States.
The effect of nitrate on VOC removal in trickle bed biofilters (1996)

Biofiltration is becoming an established economical air pollution control technology for removing volatile organic compounds (VOCs) from waste air streams. This study utilizes diethyl ether as a VOC substrate and nitrate as a nitrogen nutrient source to investigate the effect of nitrate on VOC removal. Two trickle bed biofilters with pelletized media were operated co-currently at ether loading rates of 1.78 and 3.56 kg COD/m 3 ·day respectively, with a low empty bed retention time of 25 seconds, inlet gas flow rate of 8.64 m 3 /day and nutrient liquid flow rate of 1 1/day. The ether removal efficiencies improved from 72% to over 99% with increasing influent nitrate concentration from 66.7 to 266 mg NO 3 -N/l in the higher loaded column. Throughout the experiment, nitrate persisted in the liquid effluent. The lower ether removal at low influent nitrate concentrations was not due to nitrogen shortage, which suggests that the nitrate diffusion in the biofilms is rate determining. The higher COD:N consumption ratio in the biofilter with higher ether loading also indicates that ether removal may benefit from the utilization of nitrate as an alternative electron accepter in the deeper layers of the biofilm where the oxygen may be limited.
Synthesis of protein-coated biocompatible methotrexate-loaded PLA-PEG-PLA nanoparticles for breast cancer treatment (2016)

BackgroundPLA-PEG-PLA triblock polymer nanoparticles are promising tools for targeted dug delivery. The main aim in designing polymeric nanoparticles for drug delivery is achieving a controlled and targeted release of a specific drug at the therapeutically optimal rate and choosing a suitable preparation method to encapsulate the drug efficiently, which depends mainly on the nature of the drug (hydrophilic or hydrophobic). In this study, methotrexate (MTX)-loaded nanoparticles were prepared by the double emulsion method.MethodBiodegradable polymer polyethylene glycol-polylactide acid tri-block was used with poly(vinyl alcohol) as emulsifier. The resulting methotrexate polymer nanoparticles were coated with bovine serum albumin in order to improve their biocompatibility. This study focused on particle size distribution, zeta potential, encapsulation efficiency, loading capacity, and in vitro drug release at various concentrations of PVA (0.5%, 1%, 2%, and 3%).ResultsReduced particle size of methotrexate-loaded nanoparticles was obtained using lower PVA concentrations. Enhanced encapsulation efficiency and loading capacity was obtained using 1% PVA. FT-IR characterization was conducted for the void polymer nanoparticles and for drug-loaded nanoparticles with methotrexate, and the protein-coated nanoparticles in solid state showed the structure of the plain PEG-PLA and the drug-loaded nanoparticles with methotrexate. The methotrexate-loaded PLA-PEG-PLA nanoparticles have been studied in vitro; the drug release, drug loading, and yield are reported.ConclusionThe drug release profile was monitored over a period of 168 hours, and was free of burst effect before the protein coating. The results obtained from this work are promising; this work can be taken further to develop MTX based therapies.
Comparison of Streptococcal R Antigens (1972)

At least four distinct nonspecific protein R antigens were found in streptococci of groups A, B, and C by immunodiffusion in agar gel with anti-R sera.
p53 expression in nitric oxide‐induced apoptosis (1994)

Nitric oxide (NO) is a diffusible messenger involved in several patho-physiological processes including immune-mediated cytotoxicity and neural cell killing. NO or the products of its redox chemistry can cause DNA damage and activate subsequent lethal reactions including energy depletion and cell necrosis. However, regardless of whether it is endogenously produced in response to cytokines, or generated by chemical breakdown of donor molecules, NO can also induce apoptosis in different systems. Here, we report that NO generation in response to a cytokine induced NO-synthase or by NO donors stimulates the expression of the tumor suppressor gene, p53, in RAW 264.7 macrophages or pancreatic RINm5F cells prior to apoptosis. NO-synthase inhibitors such as NG-monomethyl-L-arginine prevent the inducible NO generation as well as p53 expression and apoptosis. Since p53 expression is linked to apoptosis in some cells exposed to DNA damaging agents, we suggest that NO-induced apoptosis in these cell systems is the consequence of DNA damage and subsequent expression of this tumor suppressor gene.
Ultrafast Phenomena in Semiconductor Devices (1982)

Evolving high-speed semiconductor technology requires a more complete understanding of semiconductors on a picosecond time scale. This article discusses ultrafast phenomena that may influence device performance and describes new experimental methods utilizing short optical pulses to investigate materials and device structures.
Determination of the Vapor Density of Triacetone Triperoxide (TATP) Using a Gas Chromatography Headspace Technique (2005)

Abstract Using a GC headspace measurement technique, the vapor pressure of TATP was determined over the temperature range 12 to 60 °C. As a check on the experimental method, TNT vapor pressure was likewise computed. Values for TNT are in excellent agreement with previous published ones. For TATP the vapor pressure was found to be ~ 7 Pa at ambient conditions. This value translates to a factor of 10 4 more molecules of TATP in air than TNT at room temperature. The dependence of TATP vapor pressure on temperature can be described by the equation log 10 P (Pa)=19.791−5708/ T (K). Its heat of sublimation has been calculated as 109 kJ/mol.
Cosworth MBA Engine (1992)

<div class="htmlview paragraph">Cosworth Engineering has designed and developed a new high performance V6 street engine with a number of technical innovations. Internal Exhaust Gas Recirculation (EGR) control is achieved by combining port and plenum throttling. Port throttling allows long duration cams to achieve high specific power output while still maintaining good part throttle economy and the ability to idle smoothly at 700 rpm. The engine has been designed to comply with the most stringent emissions legislation likely to be imposed. A centrifugal air/oil separator integrated into the balance shaft provides superior Crank Case Ventilation (CCV) performance. Unique cylinder head and cylinder block structures optimise rigidity while reducing engine weight.</div>
mm Wave Initial Cell Search Analysis under UE Rotational Motion (2015)

Millimeter wave (mmW) communication has emerged as a promising component of the access link for 5G cellular systems. In order to overcome the higher free-space path loss at these frequencies, high gain, and therefore highly directional, antennas are being proposed at both ends of the link. Furthermore, in order to maintain a mobile connection with an acceptable quality of service (QOS), these highly directional antennas also need to be electronically steerable. This required dual-end steerability adds significant system complexity in terms of both initial access and connected mode procedures. Therefore, these various procedures which were originally designed for the current sub 6 GHz systems need to be re-investigated in light of this added complexity. Traditionally, sub 6 GHz mobility studies mainly focused on translational motion; however, with the dual-end highly directional links being proposed for mmW communications, rotational motion also becomes a concern. In this paper, we study the effects these steerable links have on initial network access procedures, especially in the presence of user equipment (UE) rotational motion.
Use of an anti‐apoptotic CHO cell line for transient gene expression (2013)

Transient gene expression in mammalian cells allows for rapid production of recombinant proteins for research and preclinical studies. Here, we describe the development of a polyethylenimine (PEI) transient transfection system using an anti-apoptotic host cell line. The host cell line, referred to as the Double Knockout (DKO), was generated by deleting two pro-apoptotic factors, Bax and Bak, in a CHO-K1 cell line using zinc finger nuclease mediated gene disruption. Optimized DNA and PEI volumes for DKO transfections were 50% and 30% lower than CHO-K1, respectively. During transfection DKO cells produced relatively high levels of lactate, but this was mitigated by a temperature shift to 31°C which further enhanced productivity. DKO cells expressed ∼3- to 4-fold higher antibody titers than CHO-K1 cells. As evidence of their anti-apoptotic properties post-transfection, DKO cells maintained higher viability and had reduced levels of active caspase-3 compared to CHO-K1 cells. Nuclear plasmid DNA copy numbers and message levels were significantly elevated in DKO cells. Although DNA uptake levels, as early as 40 min post-transfection, were higher in DKO cells this was not due to differences in cell surface heparan sulfate (HS) or initial endocytosis mechanism as both cell types utilized caveolae- and clathrin-mediated endocytosis to internalize DNA:PEI complexes. These results suggest that the increased transfection efficiency and titers from DKO cells are attributed to their resistance to transfection-induced apoptosis and not differences in endocytosis mechanism.
LIQUID PHASE MASS TRANSFER IN ION EXCHANGE BASED ON THE HYDRAULIC RADIUS MODEL (1973)

Applying the hydraulic-radius model to the flow in a packed bed, ion exchange liquidphase mass transfer is analysed and liquid-phase effective diffusivity, De'', based on the model is compared with the diffusivity, De, based on the film model. The maximum difference between these values was about 5% for the range of diffusivity ratio a>1 and 16% for a<1. Therefore, even if the value of De is used as an approximation, no significant error will appear. Furthermore, experimental results were correlated by the use of individual diffusivity for isotopic ion exchange and De'' for mutual ion exchange. These data satisfy the equationJ*'' ={(1-ε)/ε}1/3 k*Sc2/3£/us=1.85Re''-2/3, when Re''<100.
OFDM Modulation Classification and Parameters Extraction (2006)

A novel comprehensive classification system is proposed for recognizing the orthogonal frequency division multiplexing (OFDM) signal and extracting its parameters. An empirical distribution function-based Gaussianity test technique is first applied to distinguish OFDM from single carrier modulations. Cyclostationarity and correlation tests are then applied to estimate OFDM symbol duration and cyclic prefix duration. A bank of fast Fourier transform (FFT) bank filter is devised to detect the number of subcarriers. Numerical results are presented to verify the efficiency of the proposed scheme
Prevalence of gingival biotype and its relationship to clinical parameters (2015)

It was concluded that the prevalence of thick and thin gingival biotype is 56.75% versus 43.25%, respectively, and there is no significant relationship between age, gender, and the presence of recession to gingival biotype. A positive correlation exists between WKG and the GT.
Synthesis of (±)-versimide [methyl α-(methylsuccinimido)acrylate] and related compounds (1972)

A. G. Brown and T. C. Smale, J. Chem. Soc., Perkin Trans. 1, 1972, 65 DOI: 10.1039/P19720000065