gebhart/patrepeval huggingface dataset:
Chaotic dynamics of mode competition in a vertical-cavity surface emitting laser diode under DC excitation (1994)

We discuss the dynamics of transverse mode competition in an etched air-post vertical-cavity laser diode under dc excitation using an annular ring contact as a spatial filter. Distinct regions of operation are found for various ranges of fixed bias currents. At 1.5 times threshold, the device enters a region which exhibits chaotic fluctuations between the fundamental and a higher order lasing mode. The dynamics of these fluctuations are studied using the method of delays, and a calculation of the power spectrum and the correlation dimension are reported. It is found that the dynamics of the chaotic fluctuations have a correlation dimension of approximately 2.8. The results are indicative of a low-dimensional strange attractor underlying the modal competition noise.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections (1995)

Herpes simplex virus type 1 (HSV-1) establishes latency in human sensory ganglia, during which time the viral genome is transcriptionally silent with the exception of the latency-associated transcripts (LATs). The most abundant LAT is a 2-kb RNA whose biosynthesis is poorly characterized. The 2-kb LAT may be a primary transcript, or its synthesis may involve splicing and/or other forms of processing. Two potential RNA polymerase II promoters (LAP1 and LAP2) upstream of the 2-kb LAT 5' end have been identified. To investigate the role played by LAP1 and LAP2 in the synthesis of the 2-kb LAT under lytic and latent conditions, we analyzed HSV-1 mutants which contain deletions of one or both of these promoters. During lytic infection in cell culture, the cis elements critical for the normal accumulation of the 2-kb LAT were mapped to LAP2, while LAP1 sequences were largely dispensable. The 5' ends of the major 2-kb LATs produced by the wild-type and LAP deletion viruses were examined by primer extension analysis and were all found to be identical (+/- 2 bp). The accumulation of the 2-kb LAT during latent infections of murine trigeminal ganglia was examined by Northern (RNA) blot and by reverse transcription-PCR. In contrast to the results found in lytic infections, the critical cis elements needed for 2-kb LAT accumulation during latency were mapped to LAP1. Deletion of LAP1 resulted in a 500-fold reduction in 2-kb LAT accumulation, whereas deletion of LAP2 resulted in only a 2- to 3-fold reduction. Deletion of both LAP1 and LAP2 resulted in undetectable levels of the 2-kb LAT. Our results indicate that both LAP1 and LAP2 are critical for 2-kb LAT expression but under different conditions. LAP1 is essential for LAT expression during latency, while LAP2 is primarily responsible for LAT expression in lytic infections in cell culture. LAP1 and LAP2 may prove to be functionally independent promoter elements that control 2-kb LAT expression during different stages of HSV-1 infections.
A Survey of Concept-based Information Retrieval Tools on the Web (2001)

Abstract. In order to solve the problem of information overkill on the web current information retrieval tools need to be improved. Much more intelligence should be embedded to search tools to manage effectively search, retrieval, filtering and presenting relevant information. This can be done by concept-based (or ontology driven) information retrieval, which is considered as one of the high-impact technologies for the next ten years. Nevertheless, most of commercial products of search and retrieval category do not report about concept-based search features. The paper provides an overview of conceptbased information retrieval techniques and software tools currently available as prototypes or commercial products. Tools are evaluated using feature classification, which incorporates general characteristics of tools and their information retrieval features.
Masking-level difference for spondaic words in 2000-msec bursts of broadband noise. (1994)

One protocol developed for the Tonal and Speech Materials for Auditory Perceptual Assessment audio compact disc was the masking-level difference (MLD) for spondaic words in which the words and broadband noise were mixed and recorded at 16 selected signal-to-noise ratios. Four words were recorded at each level. Because it was impossible to monitor the word presentations at negative signal-to-noise ratios, a different paradigm was devised in which the spondaic words were embedded in 2000-msec bursts of noise. Before the materials were finalized for the compact disc, two experiments studied the perceptual characteristics of the paradigm. Experiment I was performed to determine the characteristics of the MLD for spondaic words in 2000-msec bursts of noise at 70 dB SPL. An unexpected finding was that the mean SoNo thresholds were at signal-to-noise ratios 3-4 dB lower than previously reported spondaic word thresholds in continuous broadband noise. Experiment II examined this discrepancy with the spondaic words embedded in continuous noise and in the 2000-msec noise bursts. The results confirmed the 3-4 dB difference between thresholds for the two masker conditions. Based on the pilot data, the spondaic words embedded in 2000-msec bursts of broadband noise at signal-to-noise ratios of 0 dB to -30 dB were recorded on the compact disc in the S pi No paradigm. In the compact disc trials, which involved 120 subjects with normal hearing, the MLDs for the spondaic words recorded on the compact disc were measured on 60 subjects at each of two noise levels.(ABSTRACT TRUNCATED AT 250 WORDS)
RNA interference gene therapy in dominant retinitis pigmentosa and cone-rod dystrophy mouse models caused by GCAP1 mutations (2014)

RNA interference (RNAi) knockdown is an efficacious therapeutic strategy for silencing genes causative for dominant retinal dystrophies. To test this, we used self-complementary (sc) AAV2/8 vector to develop an RNAi-based therapy in two dominant retinal degeneration mouse models. The allele-specific model expresses transgenic bovine GCAP1(Y99C) establishing a rapid RP-like phenotype, whereas the nonallele-specific model expresses mouse GCAP1(L151F) producing a slowly progressing cone-rod dystrophy (CORD). The late onset GCAP1(L151F)-CORD mimics the dystrophy observed in human GCAP1-CORD patients. Subretinal injection of scAAV2/8 carrying shRNA expression cassettes specific for bovine or mouse guanylate cyclase-activating protein 1 (GCAP1) showed strong expression at 1 week post-injection. In both allele-specific [GCAP1(Y99C)-RP] and nonallele-specific [GCAP1(L151F)-CORD] models of dominant retinal dystrophy, RNAi-mediated gene silencing enhanced photoreceptor survival, delayed onset of degeneration and improved visual function. Such results provide a "proof of concept" toward effective RNAi-based gene therapy mediated by scAAV2/8 for dominant retinal disease based on GCAP1 mutation. Further, nonallele-specific RNAi knockdown of GCAP1 may prove generally applicable toward the rescue of any human GCAP1-based dominant cone-rod dystrophy.
A Minute Deletion of the Y Chromosome in Men with Azoospermia (1993)

We analyzed deoxyribonucleic acid from 50 Japanese men with azoospermia whose Y chromosomes were cytogenetically normal. A total of 26 loci was examined in each patient. Of these patients 6 had small interstitial deletions, each of which was located within the distal part of Yq11. Five of these 6 patients lacked the same 2 loci, DYS7C and DYS1, while 1 patient had a larger deletion including DYS7C but not DYS1. More than 10% of all men with azoospermia of unknown origin may have minute interstitial deletions of the Y chromosome surrounding the DYS7C locus. The proximal part of this zone presumably encompasses the gene deletion that causes azoospermia.
Improved pertussis vaccines based on adjuvants that induce cell-mediated immunity (2014)

Bordetella pertussis is a Gram-negative bacterium that causes the severe and sometimes lethal respiratory disease whooping cough in infants and children. There has been a recent resurgence in the number of cases of pertussis in several countries with high vaccine coverage. This has been linked with waning or ineffective immunity induced by current acellular pertussis vaccines. These acellular pertussis vaccines are formulated with alum as the adjuvant, which promotes strong antibody responses but is less effective at inducing Th1-type responses crucial for effective bacterial clearance. Studies in animal models have demonstrated that replacing alum with alternative adjuvants, such as toll-like receptor agonists, can promote more robust cell-mediated immunity and confer a high level of protection against infection following respiratory challenge.
Temperature effect on liquid crystal refractive indices (2004)

A model describing the temperature effect of liquid crystal (LC) refractive indices is derived and confirmed by experiment. Two single LC compounds (5CB, 5PCH) and two mixtures (MLC-6241-000 and UCF-35) with different birefringence values were used to validate the model. This model fits all the experimental data well. For a low-birefringence LC mixture, if the operating temperature is far below its clearing point, the temperature-dependent refractive indices can be approximated as a parabolic form. This prediction is also experimentally validated. In addition, a linear relationship between 〈n2〉 and temperature is found.
MRI Reconstructions of Human Phrenic Nerve Anatomy and Computational Modeling of Cryoballoon Ablative Therapy (2015)

The primary goal of this computational modeling study was to better quantify the relative distance of the phrenic nerves to areas where cryoballoon ablations may be applied within the left atria. Phrenic nerve injury can be a significant complication of applied ablative therapies for treatment of drug refractory atrial fibrillation. To date, published reports suggest that such injuries may occur more frequently in cryoballoon ablations than in radiofrequency therapies. Ten human heart-lung blocs were prepared in an end-diastolic state, scanned with MRI, and analyzed using Mimics software as a means to make anatomical measurements. Next, generated computer models of ArticFront cryoballoons (23, 28 mm) were mated with reconstructed pulmonary vein ostias to determine relative distances between the phrenic nerves and projected balloon placements, simulating pulmonary vein isolation. The effects of deep seating balloons were also investigated. Interestingly, the relative anatomical differences in placement of 23 and 28 mm cryoballoons were quite small, e.g., the determined difference between mid spline distance to the phrenic nerves between the two cryoballoon sizes was only 1.7 ± 1.2 mm. Furthermore, the right phrenic nerves were commonly closer to the pulmonary veins than the left, and surprisingly tips of balloons were further from the nerves, yet balloon size choice did not significantly alter calculated distance to the nerves. Such computational modeling is considered as a useful tool for both clinicians and device designers to better understand these associated anatomies that, in turn, may lead to optimization of therapeutic treatments.
A stereovision based approach for detecting and tracking lane and forward obstacles on mobile devices (2015)

This paper presents SmartCoDrive, an Android application which performs driving assistance functions: 3D lane detection and tracking, forward obstacle detection, obstacle tracking. With this mobile application we wish to increase the adoption rate of driving assistance systems and to provide a viable and cheap solution for every driver, that will be able to use his own tablet or smartphone as a personal driving assistant. The mobile application is deployed on a tablet equipped with dual back-facing cameras. The visual information from the two cameras, along with the data received from the Controller Area Network bus of the vehicle enable a thorough understanding of the 3D environment. First, we develop the sparse 3D reconstruction algorithm. Then, using monocular vision we perform lane markings detection. Obstacle detection is done by combining the superpixel segmentation with 3D information and the tracking algorithm is based on the Kalman Filter. Since the processing capabilities of the mobile platforms are limited, different optimizations are carried out in order to obtain a real-time implementation. The Android application may be used in urban traffic that is characterized by low-speed and short-medium distances to obstacles.
Formation of the apical pole of epithelial (Madin-Darby canine kidney) cells: polarity of an apical protein is independent of tight junctions while segregation of a basolateral marker requires cell-cell interactions (1987)

The time course of development of polarity of an apical (184-kD) and a basolateral (63-kD) plasma membrane protein of Madin-Darby canine kidney cells was followed using semiquantitative immunofluorescence on semithin (approximately 0.5-micron) frozen sections and monoclonal antibody probes. The 184-kD protein became highly polarized to the apical pole within the initial 24 h both in normal medium and in 1-5 microM Ca2+, which results in well-spread, dome-shaped cells, lacking tight junctions and other lateral membrane interactions. In contrast, the basolateral 63-kD membrane protein developed full polarity only after incubation in normal Ca2+ concentrations for greater than 72 h, a time much longer than that required for the formation of tight junctions (approximately 18 h) and failed to polarize in 1-5 microM Ca2+. These results demonstrate that intradomain restriction mechanisms independent of tight junctions, such as self-aggregation or specific interactions with the submembrane cytoskeleton, participate in the regionalization of at least some epithelial plasma membrane proteins. The full operation of these mechanisms depends on the presence of normal cell-cell interactions in the case of the basolateral 63-kD antigen but not in the case of the apical 184-kD protein.
Effect of drag reducers on transport phenomena in turbulent pipe flow (2003)

Abstract Momentum transfer in turbulent pipe flows (d = 51 mm) with and without a drag reducer was studied. Age distributions of coherent fluid structures at the pipe wall were determined at different Reynolds numbers (10 4 <Re<6 × 10 4 ) using laser‐Doppler velocimetry (LDV) and a suitable discriminating procedure. Mean ages, mean transfer thicknesses, friction factors, and time‐averaged axial velocity profiles derived from LDV signals were compared with those from axial pressure gradients using the random surface‐renewal model. The distribution of the ages was random, and drag reducers increased the mean age and the mean transfer thickness of the fluid elements at the wall, thus decreasing momentum and heat transfer at the fluid–wall interface. The mechanism of single‐surface renewals was derived from conditionally averaged, local axial fluid velocities obtained from LDV signals.
Optimizing oxide charge balanced devices for Unclamped Inductive Switching (UIS) (2010)

Power MOSFET designs have been moving to higher performance particularly in the medium voltage area. (60V to 300V) New designs require lower Specific On-resistance while not sacrificing Unclamped Inductive Switching (UIS) capability or increasing turn-off losses. Two charge balance technologies currently address these needs, the PN junction and the Shielded Gate Charge Balance device topologies. This paper will study the impact of drift region as well as other design parameters that influence the shielded gate class of charge balance devices. The optimum design for maximizing UIS capability and minimizing the impact on other design parameters such as R DSON and switching performance are addressed. It will be shown through TCAD simulation one can design devices to have a stable avalanche point that is not influenced by small variations within a die or die-to-die that result from normal processing. Finally, measured and simulated data will be presented showing a fabricated device with near theoretical UIS capability.
Smart Computer-Assisted Markets (1991)

The deregulation movement has motivated the experimental study of auction markets designed for interdependent network industries such as natural gas pipelines or electric power systems. Decentralized agents submit bids to buy commodity and offers to sell transportation and commodity to a computerized dispatch center. Computer algorithms determine prices and allocations that maximize the gains from exchange in the system relative to the submitted bids and offers. The problem is important, because traditionally the scale and coordination economies in such industries were thought to require regulation. Laboratory experiments are used to study feasibility, limitations, incentives, and performance of proposed market designs for deregulation, providing motivation for new theory.
LL‐37 regulates the overexpression of vascular endothelial growth factor (VEGF) and c‐IAP‐2 in human keratinocytes (2008)

These results suggest that LL-37 may modulate the expression of VEGF and c-IAP-2 via HIF-1alpha in human keratinocytes.
Lightning amplitude spectra in the interval from 100 kHz to 20 MHz (1981)

The electric radiation fields produced by lightning return strokes, stepped leaders, and intracloud discharge processes have been Fourier‐analyzed to determine amplitude spectra for these processes from about 100 kHz to 20 MHz. The fields were recorded under conditions where the lightning locations were known and where the field propagation from the lightning sources to the recording site was entirely over salt water. The spectra for return strokes show an f −1 frequency dependence from 100 kHz to 2 MHz, an f −2 dependence between 2 and 10 MHz, and an f −5 decrease above 10 MHz. In the 1 to 20 MHz range, the spectra of the initial fast transition in return strokes, the initial fast‐rising portion of leader steps and the fast transitions in positive intracloud pulses are surprisingly similar.
Wafer Warpage Experiments and Simulation for Fan-Out Chip on Substrate (2016)

Fan-out chip on substrate (FOCoS) is defined as the fan-out package flip-chip mounts on high pin counts ball grid array substrate. 12-inch advanced wafer level package (aWLP) process is implemented on FOCoS for cost saving advantage. The fan-out package constructs from multi-chips with short interconnection between die to die (D2D) by re-distribution layer (RDL) process, which has the potential for high speed communication and multi-function application. In this paper, a 45×45 FOCoS package size with interconnection between two large size D2D area by three metal layers RDL process is presented. Wafer level warpage control is critical in large size fan-out package of FOCoS. Warpage performance of FOCoS is examined by advanced warpage metrology analyzer (WMA) and finite element model (FEM) in this report. 12-inch mold wafer warpage is dramatically changed through multi-RDL processes. The reliability performance of FOCoS is also evaluated to show the qualification of mass production.
Recognition, incidence, and management of oral graft-versus-host disease. (1990)

Acute and chronic graft-versus-host disease (GVHD) are significant complications of allogeneic bone marrow transplantation that occur when immunologically active T-cell lymphocytes are transplanted into an immunosuppressed recipient who is genetically disparate from the marrow donor. Oral GVHD lesions closely resemble those seen with a number of autoimmune connective tissue disease, including lichen planus, systemic sclerosis, lupus erythematosus, and Sjögren's syndrome. Mucosal erythema, atrophy, and ulceration are noted clinically; lichen planus-like lesions are the most distinctive oral lesions. Salivary gland changes include changes in both flow rate and sialochemistry. Oral involvement ranges between 33% and 75% for patients with acute GVHD and upwards of 80% for those with chronic GVHD. Management of oral GVHD lesions depends on successful systemic therapy, although topical steroids can be of help in some instances.
Use of Incineration MSW Ash: A Review (2010)

This study reviews the characteristics of municipal solid waste incineration (MSWI) ashes, with a main focus on the chemical properties of the ashes. Furthermore, the possible treatment methods for the utilization of ash, namely, separation processes, solidification/stabilization and thermal processes, are also discussed. Seven types of MSWI ash utilization are reviewed, namely, cement and concrete production, road pavement, glasses and ceramics, agriculture, stabilizing agent, adsorbents and zeolite production. The practical use of MSWI ash shows a great contribution to waste minimization as well as resources conservation.
Towards social user profiling (2012)

Users' locations are important to many applications such as targeted advertisement and news recommendation. In this paper, we focus on the problem of profiling users' home locations in the context of social network (Twitter). The problem is nontrivial, because signals, which may help to identify a user's location, are scarce and noisy. We propose a unified discriminative influence model, named as UDI, to solve the problem. To overcome the challenge of scarce signals, UDI integrates signals observed from both social network (friends) and user-centric data (tweets) in a unified probabilistic framework. To overcome the challenge of noisy signals, UDI captures how likely a user connects to a signal with respect to 1) the distance between the user and the signal, and 2) the influence scope of the signal. Based on the model, we develop local and global location prediction methods. The experiments on a large scale data set show that our methods improve the state-of-the-art methods by 13%, and achieve the best performance.
Using a Map of Measurement Noise to Improve UWB Indoor Position Tracking (2013)

Ultrawideband signals present new opportunities for indoor position tracking due to their ability to operate in non-line-of-sight conditions. However, walls and other normal indoor infrastructure cause a systemic spatial warp in the measurements. In this paper, we describe methods to manually build a map of the measurement noise and use it in a particle filter framework to improve measurement accuracy. We tested our methods in two facilities, collecting over 5.6 million measurements. Evidence shows that the measurement noise is multimodal, location dependent, stable over time, and locally similar. Using the map in a particle filter framework, we demonstrate an average improvement in measurement accuracy of 30%.
Optimization of LDPC Finite Precision Belief Propagation Decoding with Discrete Density Evolution (2003)

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