gebhart/patrepeval huggingface dataset:
A New Method for Collaborative Filtering Recommender Systems: The Case of Yahoo! Movies and TripAdvisor Datasets (2016)

Collaborative Filtering (CF) techniques, which attempt to predict what information will meet a user’s needs based on data coming from similar users, are becoming increasingly popular as ways to combat information overload. They use a single rating as input. However, the multi-criteria based CF presents a possibility to provide accurate recommendations by considering the user preferences in multiple aspects. This research proposes a new recommendation method using Adaptive Neuro Fuzzy Inference System (ANFIS) and Fuzzy Self-Organizing Map (SOM) for accuracy improvement of multi-criteria recommender systems. We also apply Principal Component Analysis (PCA) for dimensionality reduction and to address multi-collinearity induced from the interdependencies among criteria in multi-criteria CF datasets. Experimental results on Yahoo! Movies and TripAdvisor datasets demonstrated that the proposed method significantly improves recommendation accuracy of multi-criteria CF.
Uptake of Long Chain Free Fatty Acids Is Selectively Up-regulated in Adipocytes of Zucker Rats with Genetic Obesity and Non-insulin-dependent Diabetes Mellitus (1997)

To examine whether fatty acid transport is abnormal in obesity, the kinetics of [3H]oleate uptake by hepatocytes, cardiac myocytes, and adipocytes from adult male Wistar (+/+), Zucker lean (fa/+) and fatty (fa/fa), and Zucker diabetic fatty (ZDF) rats were studied. A tissue-specific increase in oleate uptake was found in fa/fa and ZDF adipocytes, in which the Vmax was increased 9-fold (p < 0.005) and 13-fold (p < 0.001), respectively. This increase greatly exceeded the 2-fold increase in the surface area of adipocytes from obese animals, and did not result from trans-stimulation secondary to increased lipolysis. Adipocyte tumor necrosis factor-alpha mRNA levels, assayed by Northern hybridization, increased in the order +/+ < fa/fa < ZDF. Oleate uptake was also studied in adipocytes from 20-24-day-old male +/+, fa/+, and fa/fa weanlings. These animals were not obese, and had equivalent plasma fatty acid and glucose levels. Tumor necrosis factor-alpha mRNA levels in +/+ and fa/fa cells also were similar. Nevertheless, Vmax was increased 2.9-fold (p < 0.005) in fa/fa compared +/+ cells. These studies indicate 1) that regulation of fatty acid uptake is tissue-specific and 2) that up-regulation of adipocyte fatty acid uptake is an early event in Zucker fa/fa rats. These findings are independent of the role of any particular fatty acid transporter. Adipocyte mRNA levels of three putative transporters, mitochondrial aspartate aminotransferase, fatty acid translocase, and fatty acid transporting protein (FATP) were also determined; mitochondrial aspartate aminotransferase and FATP mRNAs correlated strongly with fatty acid uptake.
Antibodies to glatiramer acetate do not interfere with its biological functions and therapeutic efficacy (2003)

G latiramer acetate (GA) previously known as C opolymer 1 (Cop 1), a synthetic amino acid copolymer, suppresses experimental autoimmune encephalomyelitis (EAE) and shows a beneficial effect in relapsing-remitting type of multiple sclerosis (MS). G A acts as a specific immunomodulator by binding to MHC C lass II molecules, inducing specific T suppressor (Ts) cells and interfering with T cell responses to myelin antigens. MS patients treated with GA developed GA reactive antibodies, which peaked at three months and decreased at six months. In order to find out whether anti-G A antibodies may neutralize the therapeutic effect of GA, we tested both polyclonal (mouse and human) and monoclonal G A specific antibodies for their ability to interfere with the biological activity of GA in several assay systems. None of the antibodies interfered with GA activities either in vitro (binding to MHC molecules and T cell stimulation) or in vivo (blocking of EAE). Furthermore, 53 samples of sera obtained from 34 MS patients that participated in the open label trial in Israel, and all developed G A specific antibodies, were tested for their ability to inhibit the proliferation response of GA specific Ts cell clone and to interfere with G A competitive inhibition of the response to peptide 84-102 of myelin basic protein (MBP). None of the sera inhibited and some even enhanced the in vitro activities of G A. Furthermore, representative MS sera with high titer of G A reactive antibodies did not neutralize the biological activities of G A and did not inhibit Th2 cytokine secretion by human G A specific clone. These results are consistent with the findings that the therapeutic effect of GA is not affected by GA reactive antibodies and is sustained upon long term treatment.
The HLA Molecules DQA1*0501/B1*0201 and DQA1*0301/B1*0302 Share an Extensive Overlap in Peptide Binding Specificity (2002)

Assays to measure the binding capacity of peptides for HLA-DQA1*0501/B*0201 (DQ2.3) and DQA1*0301/B*0302 (DQ3.2) were developed using solubilized MHC molecules purified from EBV-transformed cell lines. These quantitative assays, based on the principle of the inhibition of binding of a high-affinity radiolabeled ligand, were validated by examining the binding capacity of known DQ-restricted epitopes or ligands. The availability of these assays allowed an investigation of patterns of cross-reactivity between different DQ molecules and with various common DR molecules. DQ2.3 and DQ3.2 were found to have significantly overlapping peptide binding repertoires. Specifically, of 13 peptides that bound either DQ2.3 or DQ3.2, nine (69.2%) bound both. The molecular basis of this high degree of cross-reactivity was further investigated with panels of single substitution analogs of the thyroid peroxidase 632-645Y epitope. It was found that DQ2.3 and DQ3.2 bind the same ligands by using similar anchor residues but different registers. These data suggest that in analogy to what was previously described for HLA-DR molecules, HLA-DQ supertypes characterized by largely overlapping binding repertoires can be defined. In light of the known linkage of both HLA-DQ2.3 and -DQ3.2 with insulin-dependent diabetes mellitus and celiac disease, these results might have important implications for understanding HLA class II autoimmune disease associations.
The PPARgamma-selective ligand BRL-49653 differentially regulates the fate choices of rat calvaria versus rat bone marrow stromal cell populations (2008)

The data show that there are clear differences in the capacity of BRL to alter the fate choices of precursor cells in stromal (RBM) versus calvarial (RC) cell populations and that recruitment of adipocytes can occur from multiple precursor cell pools (committed preadipocyte pool, multi-/bipotential osteo-adipoprogenitor pool and conversion of osteoprogenitor cells or osteoblasts into adipocytes (transdifferentiation or plasticity)). They also show that mechanisms beyond activation of PPARgamma by its ligand are required for changing the fate of committed osteoprogenitor cells and/or osteoblasts into adipocytes.
Factors limiting the extent of isomerization of 1,2,4-tribromobenzene in the potassium anilide-ammonia system (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFactors limiting the extent of isomerization of 1,2,4-tribromobenzene in the potassium anilide-ammonia systemJoseph F. Bunnett and Irving N. FeitCite this: J. Am. Chem. Soc. 1971, 93, 5, 1201–1205Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March 1971https://pubs.acs.org/doi/10.1021/ja00734a029https://doi.org/10.1021/ja00734a029research-articleACS PublicationsRequest reuse permissionsArticle Views92Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modelling and Simulation of the IR-Drop phenomenon in integrated circuits (2013)

Scaling technology in deep-submicron has reduced the voltage supply level and increased the number of transistors in the chip, increasing the power supply noise sensitivity of the ICs. Excessive power supply noise affects the timing performance increasing the gate delay and may cause timing faults. Specifically, power supply noise induced by the currents that flow through the resistive parasitic elements of the Power Distribution Network (PDN) is called IR-Drop. This thesis deals with the modelling and simulation of logic circuits in the context of IR-drop. An original algorithm is proposed allowing to perform an event-driven delay simulation of the logic Block Under Test (BUT) while taking into account the whole chip IR-drop impact on the simulated block. To do so, we develop accurate and efficient electrical models for the currents generated by the switching gates, the propagation of the current draw through the PDN and the gate delays. First, the pre-characterization process for the dynamic currents, static currents and gate delays is described to generate a gate library. Then, another pre-characterization procedure is suggested to estimate the current distribution through the resistive PDN model. Our models are implemented in a first version of the simulator by the University of Passau in the context of a project collaboration. In addition, the impact of the parasitic capacitive elements of the PDN is analyzed and a procedure to derive the current distribution in a resistive-capacitive PDN model is proposed.
Functional Magnetic Resonance Imaging of Mild Traumatic Brain Injury (2010)

Mild traumatic brain injury (MTBI) is a serious health problem that has been difficult to study because of the relative insensitivity of established anatomical imaging techniques for detecting the associated neural damage and dysfunction. Functional magnetic resonance imaging (fMRI) offers potential for understanding the neural and functional basis of MTBI and the relationship to behavioral and somatic symptoms. This article reviews the recent fMRI literature relevant to the study of MTBI. The pathophysiology of MTBI and the neural basis of the blood oxygen level-dependent fMRI response are also considered with particular focus on important issues for using fMRI to investigate MTBI.
Design and in Vitro Activities of <i>N</i>-Alkyl-<i>N</i>-[(8-<i>R</i>-2,2-dimethyl-2<i>H</i>-chromen-6-yl)methyl]heteroarylsulfonamides, Novel, Small-Molecule Hypoxia Inducible Factor-1 Pathway Inhibitors and Anticancer Agents (2012)

The hypoxia inducible factor (HIF) pathway is an attractive target for cancer, as it controls tumor adaptation to growth under hypoxia and mediates chemotherapy and radiation resistance. We previously discovered 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide as a novel, small-molecule HIF-1 pathway inhibitor in a high-throughput cell-based assay, but its in vivo delivery is hampered by poor aqueous solubility (0.009 μM in water; log P(7.4) = 3.7). Here we describe the synthesis of 12 N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, which were designed to possess optimal lipophilicities and aqueous solubilities by in silico calculations. Experimental log P(7.4) values of 8 of the 12 new analogs ranged from 1.2-3.1. Aqueous solubilities of three analogs were measured, among which the most soluble N-[(8-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl]-N-(propan-2-yl)pyridine-2-sulfonamide had an aqueous solubility of 80 μM, e.g., a solubility improvement of ∼9000-fold. The pharmacological optimization had limited impact on drug efficacy as the compounds retained IC(50) values at or below 5 μM in our HIF-dependent reporter assay.
Traitements de la parole pour l'aide aux sourds-profonds (1987)

These Ecole polytechnique federale de Lausanne EPFL, n° 697 (1987)Laboratoire d'electromagnetisme et acoustique Reference doi:10.5075/epfl-thesis-697Print copy in library catalog Record created on 2005-03-16, modified on 2016-08-08
Four-channel pulse generator for real-time biological investigations (2004)

New advances in pulse generators for real-time fluorescence microscopy of cell electroperturbation are presented. A MicroPulser described here is constructed as part of a fluorescence imaging system to expose four independent samples on a single microscope slide to nanosecond pulsed electric fields. The all solid-state pulse generator is a totem pole design delivering 450 V pulses with 0.5-ohm source impedance. The pulse generator, voltage monitor, current monitor, four-channel selection circuit, and housekeeping are contained on a 2.5 inchtimes3.8 inch printed circuit board (PC board). Temporal features of a TTL level trigger input are replicated by the variable 0 to 450 V output pulse. Pulse width can range from 11 ns to DC with rise and fall times of about 3 ns. The pulse generator and interchangeable microscope slide reside on a customized stage insert plate for the fluorescence microscope. Optical and electrical interface to the sample on stage are made simultaneously. We describe here the design of the MicroPulser system, the pulse generator electronics, and electrode chamber for cells
One-step 360° rainbow holography with two spherical mirrors (2001)

A new optical configuration producing one-step 360 degrees rainbow holograms is presented. The method makes use of two concave mirrors in confocal position, with an annular aperture between the two. An experimental demonstration is given.
Involvement of the Programmed Death-1/Programmed Death-1 Ligand Pathway in CD4+CD25+ Regulatory T-Cell Activity to Suppress Alloimmune Responses (2007)

The blockade of the PD-1/PD-L1 pathway abrogates Treg-mediated immunoregulation, thus suggesting that the PD-1/PD-L1 pathway is required for Treg suppression of the alloreactive responses of CD4+CD25-T cells. This finding has important implications for clarifying the mechanisms of allograft rejection and GvHD.
Vector morphology and iconic neural networks (1989)

Mathematical morphology involves the geometrical analysis of shapes and textures in images. Methods of generalizing morphology are presented, and it is shown that all common image-based operators are instances of two fundamental operators where voting logic is at a pivotal point. Another generalization leads to vector operators. A sequence of vector morphology operations is similar to a multiple-layer iconic neural network. In morphology, a new operator called a weighted rank order filter becomes apparent. It is noted that massively parallel, bit serial computer architectures are the most effective way to realize the various operations discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hidden Markov models in biological sequence analysis (2001)

The vast increase of data in biology has meant that many aspects of computational science have been drawn into the field. Two areas of crucial importance are large-scale data management and machine learning. The field between computational science and biology is varyingly described as “computational biology” or “bioinformatics.” This paper reviews machine learning techniques based on the use of hidden Markov models (HMMs) for investigating biomolecular sequences. The approach is illustrated with brief descriptions of gene-prediction HMMs and protein family HMMs.
Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina (2006)

In the Chx10-null ocular retardation (or(J)) mouse, retinal progenitor cell (RPC) proliferation is impaired, and bipolar neurons, a late born cell type, fail to differentiate. It is unclear whether Chx10 is required to maintain proliferation throughout retinogenesis or whether the bipolar cell defect is an indirect effect of growth arrest. We show that Chx10 is dispensable for late-stage RPC proliferation but is essential to promote bipolar cell genesis in place of rods. Ectopic Chx10 expression drove bipolar instead of rod cell differentiation without affecting division. Converting Chx10 to an activator impaired bipolar cell differentiation, implying that repression is important for Chx10 activity. In the Chx10 null or(J) retina, only a small fraction of cells expressing mutated Chx10 mRNA were rods, but this fraction increased after p27(Kip1) inactivation, which partially rescues proliferation. Most significantly, acute Chx10 knockdown in the postnatal retina promoted rods in place of bipolar neurons without affecting division. Thus, Chx10 directly controls bipolar cell genesis by inhibiting rod differentiation independent of its temporally limited early effect on RPC proliferation.
Unified Model for the Corneal Permeability of Related and Diverse Compounds with Respect to Their Physicochemical Properties (1996)

Corneal permeability data taken from the literature were analyzed for possible quantitative relationships with physicochemical properties. Although a parabolic relationship was obtained with good correlation between lipophilicity, as expressed by the 1-octanol-water partition coefficients, log Poctanol (or the distribution coefficients, log D for ionizable compounds), and the permeability in individual analyses of compound classes such as beta-adrenoceptor blockers and steroids, the correlation was reduced when taken together. However, delta log P (i.e., log Poctanol-log Palkane) correlated inversely with the combined permeability data for beta-blockers and steroids and played a key role as a unifying variable. To a lesser extent, lipophilicity itself also contributes positively to corneal permeation. Even with the addition of miscellaneous compounds such as methanol and ibuprofen, the delta log P and lipophilicity terms were still significant. However, small molecules were likely to be underestimated, which is consistent with penetration via another pathway besides that governed by delta log P and lipophilicity.
Berührungslose Drehmomentmessung mit Wirbelstrom - Sensoren / Non-contact torque measurements using eddy current sensors (1983)

Article Berührungslose Drehmomentmessung mit Wirbelstrom - Sensoren / Non-contact torque measurements using eddy current sensors was published on December 1, 1983 in the journal tm - Technisches Messen (volume 50, issue JG).
Water Uptake and Conductivity of Cross-linked SPEEK Membranes (2008)

Water uptake is an important attribute of all membrane electrolytes, as it is related to mechanical strength, creep, and dimensional stability. Thus some means of controlling water uptake by a hydrophilic sulfonic acid polymer is desirable. This is particularly important for SPEEK, which at high degrees of sulfonation (i.e., low equivalent weight) has demonstrated substantial water uptake, on order of 10's of water molecules per sulfonic acid unit. We have attempted to control water uptake in SPEEK membranes by performing cross-linking reactions on the finished polymer. Water-soluble SPEEK (85% degree of sulfonation, or 418 g/eq EW), 1,4-benzenedimethanol, and various transition metal chloride catalysts were cast together to form a membrane that was heated at 200 oC for 10 min. The resulting insoluble membrane was shown to have conductivity comparable to an uncross-linked SPEEK membrane over a range of relative humidities.
Cognitive Radio Based Wireless Sensor Networks (2008)

In recent years, we have seen tremendous growth in the applications of wireless sensor networks (WSNs) operating in unlicensed spectrum bands. However, there is evidence that existing unlicensed spectrum is becoming overcrowded. On the other hand, with recent advances in cognitive radio (CR) technology, it is possible to apply the dynamic spectrum access (DSA) model in WSNs to get access to less congested spectrum, possibly with better propagation characteristics. In this paper we present a conceptual design of CR-based WSNs, identify the main advantages and challenges of using CR technology, and suggest possible remedies to overcome the challenges. As an illustration, we study the performance of CR-based WSN used for the automation and control applications in residential and commercial premises. Our simulation results compare the performance of a CR-based WSN with a standard ZigBee/802.15.4 WSN.
Probabilistic register allocation (1992)

A new global register allocation technique, probabilistic register allocation , is described. Probabilistic register allocation quantifies the costs and benefits of allocating variables to registers over live ranges so that excellent allocation choices can be made. Local allocation is done first, and then global allocation is done iteratively beginning in the most deeply nested loops. Because local allocation precedes global allocation, probabilistic allocation does not interfere with the use of well-known, high-quality local register allocation and instruction scheduling techniques.
Transient thermographic NDE of turbine blades (1990)

A method is proposed for the automatic inspection of jet engine turbine blades using transient infrared thermography. The blades are thermally stimulated using internal flow (water) at different temperatures. By looking on the pressure (or suction) side of the blade, it is possible to detect and locate blocked cooling passages. Differential time-resolved image analysis methods are shown to effectively improve the visibility of obstruction defects in the presence of strong temperature fluctuations across the blade. Examples of such analyse are presented.
Multimodal Imaging Probe Development for Pancreatic β Cells: From Fluorescence to PET (2020)

Pancreatic β cells are responsible for insulin secretion and are important for glucose regulation in a healthy body and diabetic disease patient without prelabeling of islets. While the conventional biomarkers for diabetes have been glucose and insulin concentrations in the blood, the direct determination of the pancreatic β cell mass would provide critical information for the disease status and progression. By combining fluorination and diversity-oriented fluorescence library strategy, we have developed a multimodal pancreatic β cell probe <b>PiF</b> for both fluorescence and for PET (positron emission tomography). By simple tail vein injection, <b>PiF</b> stains pancreatic β cells specifically and allows intraoperative fluorescent imaging of pancreatic islets. <b>PiF</b>-injected pancreatic tissue even facilitated an antibody-free islet analysis within 2 h, dramatically accelerating the day-long histological procedure without any fixing and dehydration step. Not only islets in the pancreas but also the low background of <b>PiF</b> in the liver allowed us to monitor the intraportal transplanted islets, which is the first in vivo visualization of transplanted human islets without a prelabeling of the islets. Finally, we could replace the built-in fluorine atom in <b>PiF</b> with radioactive 18F and successfully demonstrate in situ PET imaging for pancreatic islets.