gebhart/patrepeval huggingface dataset:
Effects of Neighborhood Resources on Aggressive and Delinquent Behaviors Among Urban Youths (2007)

Certain family, peer, and mentoring resources may confer benefits only in the presence of neighborhood resources. Increasing neighborhood resources should be considered in interventions designed to reduce urban youths' involvement in violence.
Pharmacokinetics of Ranitidine Following Oral Administration With Ascending Doses and With Multiple‐Fixed Doses (1985)

The aim of these studies was to further delineate pharmacokinetic characteristics of ranitidine, a new histamine H2-receptor antagonist. In one study, ranitidine was administered orally to six normal men in increasing doses of 100 mg, 150 mg, 250 mg, and 400 mg weekly over a four-week period. The peak serum concentrations increased with the corresponding increases in dose but the time needed to reach peak serum concentration did not vary significantly with increased doses. The pharmacokinetic parameters were calculated for each subject at each of the four dose levels. The total area under the curve (AUC) at the four different doses was linearly related to the dose for each individual subject; and a plot of AUC versus dose had a correlation coefficient of .886 (P less than .001). The apparent plasma clearance did not vary with the increase in dose; and the average corrected clearance values ranged between 6.7 and 10 mL/(min X kg). Elimination half-life was between 2.6 and 3.0 hours; and the volume of distribution (Vd area) was between 1.6 and 2.4 L/kg. About 35% of the ranitidine dose was excreted in the urine in the unchanged form over a 12-hour excretion interval. In the second study, ranitidine was administered orally to 12 normal subjects in doses of 150 mg and 200 mg twice daily for 28 days. The pharmacokinetic parameters for ranitidine with multiple-dose treatment were similar to those obtained with single-dose administration. Predose ranitidine concentrations (trough levels) did not increase with multiple dose administration.(ABSTRACT TRUNCATED AT 250 WORDS)
A Script-Based, Parameterized Finite Element Mesh for Design and NDE on a GPU (2014)

Finite element mesh generators exist in the public domain, a few even based on a parametric device description. The typical mesh generator requires some man–machine interaction to define the points and boundary conditions, and does not work for non-stop optimization iterations for which we need a mesh dynamically evolving through the iterations with optimization variables as changing parameters. Such mesh generators as do exist are rare, commercial, and not easily available to researchers except at great cost and never with the code to modify them to suit individual needs. We take a regular open source mesh generator and write a script-based interface as open source to run non-stop for optimization. We then use it to create a non-destructive evaluation system for army ground vehicles’ defect characterization and use it equally for machine design. A simple scheme of averaging neighbour heights gives us a smooth geometry without having to use Bezier curves. The mesh runs on the central processing unit but finite element optimization is on the graphics processing unit for speed and practicable testing times.
Efficient worm-like locomotion: slip and control of soft-bodied peristaltic robots (2013)

In this work, we present a dynamic simulation of an earthworm-like robot moving in a pipe with radially symmetric Coulomb friction contact. Under these conditions, peristaltic locomotion is efficient if slip is minimized. We characterize ways to reduce slip-related losses in a constant-radius pipe. Using these principles, we can design controllers that can navigate pipes even with a narrowing in radius. We propose a stable heteroclinic channel controller that takes advantage of contact force feedback on each segment. In an example narrowing pipe, this controller loses 40% less energy to slip compared to the best-fit sine wave controller. The peristaltic locomotion with feedback also has greater speed and more consistent forward progress
The Application of Administrative Innovation and the Principle of Law Reservation (2016)

Administration innovation means the breakthrough and reform of the existing system, while the law reservation, with its specific functions, imposes restrictions on the administrative innovation and keeps it within the framework of the rule of law. However, due to its own limitations, law reservation will restrict the innovation in administration which could not play the role of positive administration. Law reservation’s function of right protection should be given full play and the scope of the current law reservation should also be expanded so as to bring administrative innovation on the track of rule of law. At the same time, give full play to the law’s function of stimulation and as for the beneficial administrative act, relax properly the restrictions of law reservation. In order to meet the practical needs of a service administration era, law reservation has to make moderate adjustments when necessary to realize the lawless administrative innovation and make sure administrative innovation could achieve the unity of formal rule of law and substantive rule of law through the principle of proportionality and public participation.
Adaptive CQI Update and Feedback for Codebook Based MU-MIMO in E-UTRA (2009)

Codebook based multiple-input multiple-output (MIMO) precoding can significantly improve the system spectral efficiency with limited feedback and has been accepted as one of the most promising techniques for the Evolved UTRA (E-UTRA). Compared with single-user (SU) MIMO, multi-user (MU) MIMO can further improve the system spectral efficiency due to increased multi-user diversity gain. MU-MIMO is preferred for the case of a large number of users, when the total feedback overhead will become a problem. In order to reduce the feedback overhead, feedback of single channel quality indicator (CQI), e.g. rank 1 CQI, is required in E-UTRA currently. The main challenge is how to obtain CQIs of other ranks at Node B for rank adaptation with single CQI feedback. In this paper, an adaptive CQI update scheme at Node B based on statistical characteristics of CQI of various ranks is proposed. To further increase the accuracy of CQI at Node B for data transmission, an adaptive CQI feedback scheme is then proposed in which single CQI with the rank same as previously scheduled is fed back. Simulation results show that our proposed CQI update scheme can achieve 2.5-5% gain compared with the conventional method with fixed backoff. Moreover, with the proposed adaptive feedback scheme, 20-40% performance gain can be obtained and the performance can approach the upper bound.
Review of the literature for dry reprocessing oxide, metal, and carbide fuel: The AIROX, RAHYD, and CARBOX pyrochemical processes (1979)

The state of the art of dry processing oxide, carbide, and metal fuel has been determined through an extensive literature review. Dry processing in one of the most proliferation resistant fuel reprocessing technologies available to date, and is one of the few which can be exported to other countries. Feasibility has been established for oxide, carbide, and metal fuel on a laboratory scale, and large-scale experiments on oxide and carbide fuel have shown viability of the dry processing concept. A complete dry processing cycle has been demonstrated by multicycle processing-refabrication-reirradiation experiments on oxide fuel. Additional experimental work is necessary to: (1) demonstrate the complete fuel cycle for carbide and metal fuel, (2) optimize dry processing conditions, and (3) establish fission product behavior. Dry process waste management is easier than for an aqueous processing facility since wastes are primarily solids and gases. Waste treatment can be accomplished by techniques which have been, or are being, developed for aqueous plants.
MALT1 Auto-Proteolysis Is Essential for NF-κB-Dependent Gene Transcription in Activated Lymphocytes (2014)

Mucosa-associated lymphoid tissue 1 (MALT1) controls antigen receptor-mediated signalling to nuclear factor κB (NF-κB) through both its adaptor and protease function. Upon antigen stimulation, MALT1 forms a complex with BCL10 and CARMA1, which is essential for initial IκBα phosphorylation and NF-κB nuclear translocation. Parallel induction of MALT1 protease activity serves to inactivate negative regulators of NF-κB signalling, such as A20 and RELB. Here we demonstrate a key role for auto-proteolytic MALT1 cleavage in B- and T-cell receptor signalling. MALT1 cleavage occurred after Arginine 149, between the N-terminal death domain and the first immunoglobulin-like region, and did not affect its proteolytic activity. Jurkat T cells expressing an un-cleavable MALT1-R149A mutant showed unaltered initial IκBα phosphorylation and normal nuclear accumulation of NF-κB subunits. Nevertheless, MALT1 cleavage was required for optimal activation of NF-κB reporter genes and expression of the NF-κB targets IL-2 and CSF2. Transcriptome analysis confirmed that MALT1 cleavage after R149 was required to induce NF-κB transcriptional activity in Jurkat T cells. Collectively, these data demonstrate that auto-proteolytic MALT1 cleavage controls antigen receptor-induced expression of NF-κB target genes downstream of nuclear NF-κB accumulation.
Topical Tacrolimus for the Treatment of Lymphedema (2015)

Gardenier, Jason C. MD; Torrisi, Jeremy S.; Savetsky, Ira L. MD; García Nores, Gabriela D. MD; Jowhar, Dawit K. PhD; Hespe, Geoffrey E.; Nitti, Matthew D.; Kataru, Raghu P. PhD; Mehrara, Babak J. MD, FACS Author Information
Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell Carcinomas (2004)

In this study, endogenous long chain ceramides were measured in 32 human head and neck squamous cell carcinoma (HNSCC) and 10 nonsquamous head and neck carcinoma tumor tissues, as compared with adjacent noncancerous tissues, by liquid chromatography/mass spectroscopy. Interestingly, only one specific ceramide, C(18:0)-ceramide, was selectively down-regulated in the majority of HNSCC tumor tissues. On the other hand, in nonsquamous tumor tissues, this selectivity for C18-ceramide was not detected. These data suggested the hypotheses that decreased levels of C18-ceramide might impart a growth advantage to HNSCC cells and that increased generation of C18-ceramide may be involved in the inhibition of growth. These roles were examined by reconstitution of C18-ceramide at physiologically relevant concentrations in UM-SCC-22A cells (squamous cell carcinoma of hypopharynx) via overexpression of mammalian upstream regulator of growth and differentiation factor 1 (mUOG1), a mouse homologue of longevity assurance gene 1 (mLAG1), which has been shown to specifically induce the generation of C18-ceramide. Liquid chromatography/mass spectroscopy analysis showed that overexpression of the mLAG1/mUOG1 resulted in increased levels of only C(18:0)-ceramide by approximately 2-fold, i.e. concentrations similar to those of normal head and neck tissues. Importantly, increased generation of C18-ceramide by mLAG1/mUOG1 inhibited cell growth (approximately 70-80%), which mechanistically involved the modulation of telomerase activity and induction of apoptotic cell death by mitochondrial dysfunction. In conclusion, this study demonstrates, for the first time, a biological role for LAG1 and C18-ceramide in the regulation of growth of HNSCC.
Preventing Catheter-Related Bacteriuria (1999)

Up to 25% of hospitalized patients undergo urinary catheterization, and about 5% develop bacteriuria each day of catheterization. Catheter-related bacteriuria is associated with increased morbidity and mortality. We performed an evidence-based synthesis of the literature on preventing catheter-associated urinary tract infections (UTIs) to develop recommendations for clinicians. Catheterization should be avoided when not required and when needed, should be terminated as soon as possible. Use of suprapubic and condom catheters may be associated with a lower risk of UTI than use of urethral catheters. Aseptic catheter insertion and a properly maintained closed drainage system are crucial to reducing the risk of bacteriuria. Instillation of antimicrobial agents into the bladder or urinary drainage bag and rigorous meatal cleansing seem to be of little benefit. Use of urinary catheters coated with silver alloy may reduce the risk of UTI. Systemic antimicrobial drug therapy seems to prevent UTIs, but primarily for patients catheterized for 3 to 14 days. Antibiotic drug prophylaxis is especially valuable in patients undergoing transurethral resection of the prostate or renal transplantation. Using these methods, urinary catheter-associated UTI can often be prevented for weeks, but not longer terms.
Approximately maximizing efficiency and revenue in polyhedral environments (2007)

We consider a resource allocation game in polyhedral environments. Polyhedral environments model a wide range of problems, including bandwidth sharing, some models of Adwords auctions and general resource allocation. We extend the fair sharing mechanism for such resource allocation games. We show that our mechanism simultaneously creates approximately efficient allocations andallapproximately maximizes revenue. We also develop a new approach for analyzing games of these types. At the core of this approach is the relation between the condition for Nash equilibriums of the game and the dual of a certain linear program.
A Second T-Region of the Soybean-Supervirulent Chrysopine-Type Ti Plasmid pTiChry5, and Construction of a Fully Disarmed <i>vir</i> Helper Plasmid (2000)

Agrobacterium tumefaciens Chry5, which is particularly virulent on soybeans, induces tumors that produce a family of Amadori-type opines that includes deoxyfructosyl glutamine (Dfg) and its lactone, chrysopine (Chy). Cosmid clones mapping to the right of the known oncogenic T-region of pTiChry5 conferred Amadori opine production on tumors induced by the nopaline strain C58. Sequence analysis of DNA held in common among these cosmids identified two 25-bp, direct repeats flanking an 8.5-kb segment of pTiChry5. These probable border sequences are closely related to those of other known T-regions and define a second T-region of pTiChry5, called T-right (TR), that confers production of the Amadoriopines. The oncogenic T-left region (TL) was located precisely by identifying and sequencing the likely border repeats defining this segment. The two T-regions are separated by approximately 15 kb of plasmid DNA. Based on these results, we predicted that pKYRT1, a vir helper plasmid derived from pTiChry5, still contains all of TR and the leftmost 9 kb of TL. Consistent with this hypothesis, transgenic Arabidopsis thaliana plants selected for with a marker encoded by a binary plasmid following transformation with KYRT1 co-inherited production of the Amadori opines at high frequency. All opine-positive transgenic plants also contained TR-DNA, while those plants that lacked TR-DNA failed to produce the opines. Moreover, A. thaliana infected with KYRT1 in which an nptII gene driven by the 35S promoter of Cauliflower mosaic virus was inserted directly into the vir helper plasmid yielded kanamycin-resistant transformants at a low but detectable frequency. These results demonstrate that pKYRT1 is not disarmed, and can transfer Ti plasmid DNA to plants. A new vir helper plasmid was constructed from pTiChry5 by two rounds of sacB-mediated selection for deletion events. This plasmid, called pKPSF2, lacks both of the known T-regions and their borders. pKPSF2 failed to transfer Ti plasmid DNA to plants, but mobilized the T-region of a binary plasmid at an efficiency indistinguishable from those of pKYRT1 and the nopaline-type vir helper plasmid pMP90.
New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome (2010)

M3 muscarinic acetylcholine receptor (M3R) plays a crucial role in the secretion of saliva from salivary glands. It is reported that some patients with Sjögren's syndrome (SS) carried inhibitory autoantibodies against M3R. The purpose of this study is to clarify the epitopes and function of anti-M3R antibodies in SS. We synthesized peptides encoding the extracellular domains of human-M3R including the N-terminal region and the first, second and third extracellular loops. Antibodies against these regions were examined by enzyme-linked immunosorbent assay in sera from 42 SS and 42 healthy controls. For functional analysis, human salivary gland (HSG) cells were preincubated with immunoglobulin G (IgG) separated from sera of anti-M3R antibody-positive SS, -negative SS and controls for 12 h. After loading with Fluo-3, HSG cells were stimulated with cevimeline hydrochloride, and intracellular Ca(2+) concentrations [(Ca(2+) )i] were measured. Antibodies to the N-terminal, first, second and third loops were detected in 42·9% (18 of 42), 47·6% (20 of 42), 54·8% (23 of 42) and 45·2% (19 of 42) of SS, while in 4·8% (two of 42), 7·1% (three of 42), 2·4% (one of 42) and 2·4% (one of 42) of controls, respectively. Antibodies to the second loop positive SS-IgG inhibited the increase of (Ca(2+) )i induced by cevimeline hydrochloride. Antibodies to the N-terminal positive SS-IgG and antibodies to the first loop positive SS-IgG enhanced it, while antibodies to the third loop positive SS-IgG showed no effect on (Ca(2+) )i as well as anti-M3R antibody-negative SS-IgG. Our results indicated the presence of several B cell epitopes on M3R in SS. The influence of anti-M3R antibodies on salivary secretion might differ based on these epitopes.
Preparation of Amino-Functionalized Graphene Sheets and Their Conductive Properties (2013)

Amino-functionalized graphene sheets were prepared through chemical reduction by hydrazine hy-drate, amination or amidation of graphite oxide. For amination of graphite oxide were used polyamine such as ethylenediamine, diethylenetriamine and triethylenetetramine. Addition of amine groups to graphene is identified by Fourier transform infrared spectroscopy, Raman spectroscopy, elemental analysis and ther-mogravimetry. Scanning electron microscopy data indicate that the organic amine is not only as nitrogen sources to obtain the nitrogen-doped graphene but also as an important modification to control the assem-bly of graphene sheets in the 3D structures. The electrical conductivity of the materials obtained by amina-tion and amidation of graphene is much smaller than that of reduced graphite oxide. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35639
Bipyridyl radical cations. Part I. Electron spin resonance study of the dimerisation equilibrium of morphamquat radical cation in methanol (1975)

We have studied the e.s.r. spectra of methanol solutions of the morphamquat {bis-1,1′-[(2,6-dimethylmorpholin-4-yl)carbonylmethyl]bipyridyl} radical cation (I) from +40 to –80°. The value of the splitting constants obtained are A(pyridyl N) 0.400, A[pyridyl H(3)] 0.142, A[pyridyl H(2)] 0.048, A(NCH2) 0.245, and A(morpholine N) 0.024 mT. It is found that as the temperature decreases the concentration of the radical cation decreases until at –80° there is no e.s.r. spectrum. This process is reversible. Concentration experiments show that the morphamquat radical cation is in equilibrium with a dimeric diamagnetic species. The ΔH° value for the equilibrium is found to be –45.05 ± 0.3 kJ mol–1. The ΔG° and ΔS° values at 25 °C are –10.6 kJ mol–1 and –115.6 J mol–1 K–1 respectively.
Recent Progress in Binocular Design: The 8 × 56 (2000)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Walter Besenmatter, "Recent Progress in Binocular Design: The 8 × 56," Optics & Photonics News 11(11), 30-33 (2000) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Development of an Enzymatic Process for the Production of (<i>R</i>)-2-Butyl-2-ethyloxirane (2017)

An epoxide resolution process was rapidly developed that allowed access to multigram scale quantities of (R)-2-butyl-2-ethyloxirane 2 at greater than 300 g/L reaction concentration using an easy-to-handle and store lyophilized powder of epoxide hydrolase from Agromyces mediolanus. The enzyme was successfully fermented on a 35 L scale and stability increased by downstream processing. Halohydrin dehalogenases also gave highly enantioselective resolution but were shown to favor hydrolysis of the (R)-2 epoxide, whereas epoxide hydrolase from Aspergillus niger instead provided (R)-7 via an unoptimized, enantioconvergent process.
Design principle and prototyping of a direct photosynthetic/metabolic biofuel cell (DPMFC) (2006)

A novel design of a photosynthetic/metabolic-based biofuel cell and its fabrication process have been explored and developed. Novel nanostructure and modified polyaniline have been used to enhance the performance of the new biofuel cell. The mechanism of the electron transfer process and the electro-catalysis of polyaniline have been investigated. The developed direct photosynthetic/metabolic biofuel cells (DPMFC) succeeded in generating a peak current density of more than 150 µA cm−2 with a 100 Ω load, 5.3 µW cm−2 of maximum power density (using prototype fuel cell). The benefits of DPMFC are that it can produce power in dark/light, is unharmful to living things and does not need a fuel supply.
Anion exchange separation for the determination of uranium in complex solutions (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnion exchange separation for the determination of uranium in complex solutionsOrlando A. Vita, Carl Ray. Walker, C. F. Trivisonno, and R. W. SparksCite this: Anal. Chem. 1970, 42, 4, 465–469Publication Date (Print):April 1, 1970Publication History Published online1 May 2002Published inissue 1 April 1970https://pubs.acs.org/doi/10.1021/ac60286a014https://doi.org/10.1021/ac60286a014research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Milk Fat Depression in Dairy Cows - Influence of Supplemental Fats (2006)

Supplementing cows with fat can have several beneficial effects. It usually increases the energy density of the diet when starch or fiber is replaced with fatty acids. If milk production is increased, then feed efficiency may be improved which usually