gebhart/patrepeval huggingface dataset:
Gigabyte/s data communications with the POLO parallel optical link (2002)

The progress in the development of the 10 channel POLO (Parallel Optical Link Organization) module is described. The POLO program is a consortium of Hewlett-Packard, AMP, Du Pont, SDL, and the University of Southern California to develop low cost, high performance parallel optical data links for computer clusters, multimedia, and switching systems. The design and initial performance of the 1st generation POLO module (POLO-I) have been previously reported. In this paper, we discuss the overall results of the POLO-1 module as well as the design and implementation of the 2nd generation (POLO-2) parallel optical data link.
Reactive Microservices in Commodity Resources (2019)

A microservice is a cohesive, independent process that communicates via messages. Reactive microservices consist of isolated components in an event stream that can react independently or in concert with other microservices to arrive at the final states of the event. n this paper, we present a microservice architecture which is based on event streams and has a decentralized framework for microservice coordination. The architecture allows microservices to enrich content in an event stream without any time or mobility constraints. Final states are construed as acceptable and incrementally stackable for event updates that occur at different time slots. The event coordinator platform establishes the coordination within a microservice using the event registry. We present how we horizontally scaled the platform with multiple parallelism strategies and show the platform performance results.
Preparative and stereochemical features of the sulfoxide-sulfenate [2,3]sigmatropic rearrangement in 17-vinyl-17-hydroxysteroids (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparative and stereochemical features of the sulfoxide-sulfenate [2,3]sigmatropic rearrangement in 17-vinyl-17-hydroxysteroidsEnrico Morera and Giorgio OrtarCite this: J. Org. Chem. 1983, 48, 1, 119–121Publication Date (Print):January 1, 1983Publication History Published online1 May 2002Published inissue 1 January 1983https://pubs.acs.org/doi/10.1021/jo00149a023https://doi.org/10.1021/jo00149a023research-articleACS PublicationsRequest reuse permissionsArticle Views83Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Entrapment of an anionic, stable, moisture-resistant oxygen carrier in zeolite Y (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEntrapment of an anionic, stable, moisture-resistant oxygen carrier in zeolite YRussell S. Drago, Iwona. Bresinska, James E. George, Kenneth. Balkus, and Robert J. TaylorCite this: J. Am. Chem. Soc. 1988, 110, 1, 304–305Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ja00209a057https://doi.org/10.1021/ja00209a057research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Periodic Limb M[ovements in Sleep in Community-Dwelling Elderly (1991)

The prevalence of periodic limb movements in sleep (PLMS) in a randomly selected elderly sample is reported. In San Diego, 427 elderly volunteers aged 65 yr and over were recorded in their homes. Forty-five percent had a myoclonus index, MI greater than or equal to 5. Correlates of PLMS included dissatisfaction with sleep, sleeping alone and reported kicking at night. Although statistically significant, the strengths of the associations between interview variables and myoclonus indices were all small. No combination of demographic variables and symptoms allowed highly reliable prediction of PLMS.
The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn's disease and ulcerative colitis patients (2006)

The bacterial community (microbiota) that inhabits the gut of humans appears to be an important source of antigens that drive the chronic immunological processes characteristic of Crohn's disease (CD) and ulcerative colitis (UC). Most of the members of the microbiota have not yet been cultured, but nucleic-acid-based methods of detection and enumeration can provide information about the community. This investigation used these methods to obtain information about the bacteria associated with mucosal surfaces in the gut of 20 CD and 15 UC patients. Biopsies were collected from inflamed and non-inflamed sites in the intestines of newly diagnosed, untreated patients. Biopsies were also collected from several intestinal sites of 14 healthy subjects. The bacterial collections associated with the biopsies were analysed by generating PCR/denaturing gradient gel electrophoresis (DGGE) profiles, the preparation of 16S rRNA gene clone libraries, and qualitative PCR to detect specific groups of bacteria. The total numbers of bacteria associated with the biopsies were determined by real-time quantitative PCR. DGGE profiles generated from the terminal ileum and various colonic regions were characteristic of each individual but differed between subjects. DGGE profiles and 16S rRNA gene libraries showed that the bacteria associated with inflamed and non-inflamed tissues did not differ. UC patients had more bacteria associated with biopsies than did CD patients (P<0.01). Statistical analysis of the composition of 16S rRNA gene libraries showed that the bacterial collections in UC and CD patients differed (P<0.05). Unclassified members of the phylum Bacteroidetes were more prevalent in CD than in UC patients. Therefore, the types and numbers of bacteria associated with biopsy samples were distinctly different for UC and CD patients. The observations made in this study should permit targeting of specific bacteriological abnormalities in investigations of the pathogenesis of inflammatory bowel diseases and provide targets for medical interventions.
[A relationship between insulin resistance and reduction in oxidative stress in vivo by atorvastatin]. (2004)

Insulin resistance is important in the occurrence of oxidative stress in patients with hypercholesterolemia. Since atorvastatin does not reduce insulin resistance, further therapy to reduce insulin resistance is necessary for early prevention of cardiovascular events during atorvastatin treatment.
High Fill Factor and Open Circuit Voltage in Organic Photovoltaic Cells with Diindenoperylene as Donor Material (2010)

Abstract Small‐molecule photovoltaic cells using diindenoperylene (DIP) as a new donor material in combination with the fullerene C 60 as an electron acceptor are demonstrated. In addition to the successful application in planar and bulk heterojunction devices, a comprehensive analysis including structural studies, the determination of the energy level alignment and electrical transport investigations is given, stressing the correlation between growth conditions, film morphology, and device performance. Due to pronounced crystallinity and a large surface area of DIP films grown at elevated temperature, exceptionally high fill factors of almost 75% are achieved in planar heterojunction cells. Bulk heterojunctions exhibit large‐scale phase separation forming a bicontinuous network of both molecular species, which enables efficient exciton dissociation and charge carrier transport. The high ionization potential of DIP and the favorable energy level alignment with the fullerene C 60 yield large open circuit voltages close to 1 V and comparable power conversion efficiencies of about 4% in both cell architectures.
Hearing in Patients with Intracanalicular Vestibular Schwannomas Per Caye (2007)

This paper reports data on the spontaneous course of hearing in 156 patients with purely intracanalicular vestibular schwannomas. The mean pure tone average (PTA) was 51 dB HL and the mean speech discrimination score (SDS) 60% at diagnosis. The risk of a significant subsequent hearing loss (10 dB PTA or 10% SDS) was 54% during 4.6 years of observation. Patients with normal speech discrimination at diagnosis had a significantly smaller risk of loosing hearing. The hearing loss at diagnosis and during observation was not related to age, gender, diagnostic tumor size, tumor- induced expansion of the internal auditory canal or tumor sublocalization (fundus, central or porus). However, the loss of PTA was smaller in shrinking tumors and the PTA deterioration rate correlated with the volumetric tumor growth rate. After 4.6 years observation, the PTA had increased by 14 dB to 65 dB HL, and the SDS reduced by 17% to 43%. The proportion of patients eligible for hearing preservation treatment as determined by word recognition score class I (70-100% SDS) was reduced to 28% (a 44% reduction), and by AAO-HNS class A to 9% (a 53% reduction).
DNA REPAIR IN HUMANS (1995)

DNA repair is an important molecular defense system against agents that cause cancer, degenerative diseases, and aging. Several repair systems in humans protect the genome by repairing modified bases, DNA adducts, crosslinks, and double strand breaks. These repair systems, base excision, nucleotide excision, and recombination, are intimately connected to transcription and to cell cycle checkpoints. In addition, genotoxic stress induces a set of cellular reactions mediated by the p53 tumor suppressor and the Ras oncogene. These genotoxic response reactions may help the cell survive or enter apoptosis. Damage-response reactions may be utilized as targets of anticancer chemotherapy.
Evaluation of a commercial enzyme‐linked immunosorbent assay for detection of antibodies against the H5 subtype of <i>Influenza A virus</i> in waterfowl (2012)

The ID Screen Influenza H5 Antibody Competition enzyme-linked immunosorbent assay was tested for the detection of antibodies to the H5 subtype of influenza A (IA) virus in waterfowl. Assays were conducted with sera obtained from Mallards (Anas platyrhynchos) and Pekin Ducks (Anas platyrhynchos domestica), experimentally infected with eight low pathogenic (LP) and nine highly pathogenic (HP) H5N1 IA viral strains. Three incubation periods (1, 4 and 18 hours) and two dilutions (1:2 and 1:5) were tested. All serum samples from LP H5-infected birds tested positive; however, improved detection rates were observed for viruses belonging to the HP H5N1 clade 2.2.1 as compared with those belonging to clade 2.1.3.
NOVEL FORMS OF INSULIN DELIVERY (1997)

Despite its widespread use, much is wrong with conventional subcutaneous insulin injection. It is more-or-less painful and inconvenient; it delivers insulin slowly with highly inconsistent pharmacokinetics into the peripheral venous system rather than directly to the liver via the portal vein; and, once delivered into the skin, it cannot be "turned off". This review has focused on novel alternative approaches to insulin delivery. The clinically available insulin delivery devices, such as pen injectors and external insulin pumps, are probably underutilized. Pen injectors offer convenience, whereas external pumps offer a basal/bolus approach to insulin delivery unlike that achieved by injections. Of the approaches currently under development, IPPs are closet to general availability. They have been extremely popular in more than 600 patients worldwide, however, an insulin problem has delayed application for their PMA in the United States. Feasibility studies of inhaled insulin, nasal insulin, and oral insulin have produced interesting preliminary findings, with pulmonary delivery for meal coverage with short-acting insulin having perhaps the brightest prospects. Encapsulated islets and biohybrid systems that place live islets into an implanted device are in earlier stages of development. Closing the loop with a continuous glucose sensor will be the only way to achieve truly normal blood glucose homeostasis by directing insulin delivery automatically on demand. Glucose sensors would have many other clinical applications in diabetes management in addition to driving a mechanical delivery system. However, the development of glucose sensing devices has been a formidable technical challenge. Based on an evaluation of current technologic development, glucose oxidase-based, needle-type sensors may become available within the next few years. Clinicians, the research community, and persons with diabetes can join in rejecting the notion that standard regimens of insulin injection do not need to be improved. If there is adequate incentive to continue a broad-based research effort into novel approaches to insulin delivery, the quality of life of persons with diabetes can be improved in the not too distant future.
A Case For Sealing Classes In Java (2002)

It is a well-known fact that inheritance as defined in most existing object-oriented languages breaks encapsulation in a very subtle way. For instance, Java provides facilities for encapsulation both at the class-level and at the packagelevel.
Inhibition of dendritic cell IL-12 production by <i>Giardia lamblia</i> (44.1) (2007)

Abstract Unlike most other enteric infections, Giardia lamblia infection does not typically induce mucosal inflammation. We therefore studied the response of bone marrow-derived dendritic cells (BMDCs) to Giardia extracts. G. lamblia is only a weak activator of BMDCs. Compared to LPS, co-incubation of G. lamblia extract results in only moderate up-regulation of the co-stimulatory molecules CD80 and CD86. In addition, G. lamblia extract causes minimal induction of IL-6 and TNF and no detectable IL-10 or IL-12. Interestingly, pre-exposure of BMDCs to G. lamblia extract inhibits the secretion of the pro-inflammatory cytokine IL-12 by LPS activated BMDCs. IL-12 suppression by G. lamblia is apparently dependent on its activation of the phosphotidylinositol 3-Kinase (PI3-K) pathway, as it is abrogated by pretreatment of BMDCs with the specific PI3-Kinase inhibitor, wortmannin. These results suggest that Giardia actively prevents inflammation, and suggests a distinct mechanism of immune regulation by this intestinal parasite.
Continuous rotary kiln calcination of yttrium barium copper oxide precursor powders (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTContinuous rotary kiln calcination of yttrium barium copper oxide precursor powdersSuhas D. Shelukar, H. G. Keshava Sundar, Raphael Semiat, James T. Richardson, and Dan LussCite this: Ind. Eng. Chem. Res. 1994, 33, 2, 421–427Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ie00026a038https://doi.org/10.1021/ie00026a038research-articleACS PublicationsRequest reuse permissionsArticle Views142Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Topical Antimicrobials in Pediatric Burn Wound Management (2008)

Burn trauma continues to injure an estimated 1 million children each year in the United States alone, with many more injuries suffered worldwide. Several decades ago, advances in acute burn wound management, including development of topical antimicrobials, dramatically improved outcomes in pediatric burn injuries. However, infection remains the leading cause of burn wound mortality. With increasing antibiotic resistance in many medical centers, precise selection of topical antimicrobial therapy has grown in importance for pediatric burn management. Effective choice and application of topical antimicrobials require correct classification of burn wounds, appropriate understanding of the process of burn wound sepsis, and accurate identification of pathogens for individual patients as well as for their surrounding environment. This article examines the current and evolving role of topical antimicrobials in pediatric burn wound management. Burn wound classification, the biologic process of burn wound sepsis, wound cultures with pathogen profiling, and evaluations of commonly used topical antimicrobials are reviewed. Newer biologically active occlusive (bio-occlusive) and hybrid products are examined in the context of topical antimicrobial therapy and their increasing role in pediatric burn wound management.
The effect of thiazide diuretics on coronary risk factors. (1979)

Benzothiadiazine diuretics (thiazides) were introduced twenty years ago (Hollander and Wilkins, 1957), and remain the most commonly used type of antihypertensive drug. Their long term use alone provides smooth control of blood pressure in mild to moderate hypertensives (Beevers, Hamilton and Harpur, 1971), and they are also valuable as adjuvant therapy with other antihypertensive drugs. Whilst thiazides are virtually free of any clinical side effects, they do cause many biochemical changes, the significance of which is uncertain. Many of these biochemical abnormalities are possible risk factors for the development of coronary heart disease (C.H.D.), or other serious conditions. The magnitude and importance of these changes are discussed in this review.
Evaluation of a time-delay based geolocation algorithm in real UMTS networks (2010)

Time-delay geolocation based on information reported in measurements reports (MRs) is possible for mobile stations (MSs) making active calls in a live UMTS network. This paves the way for important applications like traffic map generation or accurate radio propagation modeling. Nevertheless, there is a number of constraints that will impact the accuracy of geolocation of MSs such as multipath, limited number of measured base transceiver stations (BTSs), non-perfect BTS synchronization recovery, measurements errors, and MRs not being sent in a continuous way but in an event-driven fashion. This paper quantifies the effect of the aforementioned limitations in real networks with the help of drive-test measurements, proposes several techniques to mitigate them, and finally analyzes in detail the impact on the geolocation accuracy.
IL‐1β receptor blockade protects islets against pro‐inflammatory cytokine induced necrosis and apoptosis (2009)

Pro-inflammatory cytokines (PIC) impair islet viability and function by activating inflammatory pathways that induce both necrosis and apoptosis. The aim of this study was to utilize an in vitro rat islet model to evaluate the efficacy of a clinically approved IL-1 receptor antagonist (Anakinra) in blocking PIC induced islet impairment. Isolated rat islets were cultured for 48 h +/- PIC (IL-1beta, IFNgamma, and TNFalpha) and +/-IL-1ra then assayed for cellular integrity by flow cytometry, MAPK phosphorylation by proteome array, and gene expression by RT-PCR. Nitric oxide (NO) release into the culture media was measured by Griess reaction. Islet functional potency was tested by glucose stimulated insulin secretion (GSIS) and by transplantation into streptozotocin-induced diabetic NOD.scid mice. Rat islets cultured with PIC upregulated genes for NOS2a, COX2, IL6, IL1b, TNFa, and HMOX1. IL-1ra prevented the PIC induced upregulation of all of these genes except for TNFa. Inhibition of PIC induced iNOS by NG-monomethyl-L-arginine (NMMA) only blocked the increased expression of HMOX1. IL-1ra completely abrogated the effects of PIC with respect to NO production, necrosis, apoptosis, mitochondrial dysfunction, GSIS, and in vivo potency. IL-1ra was not effective at preventing the induction of necrosis or apoptosis by exogenous NO. These data demonstrate that Anakinra is an effective agent to inhibit the activation of IL-1beta dependent inflammatory pathways in cultured rat islets and support the extension of its application to human islets in vitro and potentially as a post transplant therapy.
Diffusion Based Photon Mapping (2008)

Abstract Density estimation employed in multi‐pass global illumination algorithms give cause to a trade‐off problem between bias and noise. The problem is seen most evident as blurring of strong illumination features. In particular, this blurring erodes fine structures and sharp lines prominent in caustics. To address this problem, we introduce a photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way, we preserve important illumination features, while eliminating noise. We demonstrate the applicability of our algorithm through a series of tests. In the tests, we evaluate the visual and computational performance of our algorithm comparing it to existing popular algorithms.