gebhart/patrepeval huggingface dataset:
Alkyl, styryl and aryl transfer between cobalt and pyrrolic nitrogen of cobalt porphyrins (1984)

Action de CF 3 COOH/O 2 sur les alkyl, α-styryl et arylcobalt(III) porphyrines. Mecanisme reactionnel. Cette reaction est un bon modele des dernieres etapes de l'hydrazinolyse des hemoproteines
Characteristics of an arc discharge in sulphur hexafluoride (1967)

Voltage gradients and electrode-fall voltages have been measured for an SF6 arc burning in a 6.35mm-diameter tube. The voltage gradients are lower than those in a nitrogen arc, the reason being that the thermal conductivity of the SF6-arc plasma is lower, than that of a nitrogen plasma. Using previously calculated electrical and thermal conductivities the theoretical voltage gradients agree very closely with those measured. Also, the radial temperature distributions for various SF6 arcs have been calculated, the agreement with the measured distributions obtained by Maecker and Motschmann being very good. For low currents, the calculated temperature distributions show that the SF6 arc is very narrow and filamentary compared to an arc in nitrogen or air; this is in agreement with visual and photographic observations. The main reason for this is the dissociation of the SF6 molecule at a temperature of 21000°K, resulting in a large peak in the thermal conductivity. Thus the time constant of the SF6 arc is much lower than that of the nitrogen arc. This, coupled with the dastic reduction of the electron concentration below 5000°K by the formation of negative fluorine ions, results in the excellent arc-quenching properties of the gas.
Notes on Voltage-Tunable Nonlinear Resistance-Capacitance Networks (1964)

Nonlinear resistances possess dynamic resistances that can be electrically varied over a range of many orders of magnitude. In this respect, they are far more nonlinear than contemporary nonlinear reactances. Some general criteria for obtaining maximum voltage tunability are discussed and several networks possessing zero-phase frequencies are presented for possible use in wide-range voltage-tunable resistor-capacitor (RC) networks.
Isolation and characterization of a new 16-membered lactone, protylonolide, from a mutant of tylosin-producing strain, Streptomyces fradiae KA-427. (1980)

A new 16-membered lactone named protylonolide was isolated from the culture of the blocked mutant of Streptomyces fradiae, KA-427. Protylonolide was converted to tylosin by both parent strain and several tylosin-non-producing mutants of KA-427. Protylonolide is an important biosynthetic intermediate of tylosin.
A comparison of methods of lidocaine administration in patients (1981)

A three-step method for administering lidocaine intravenously was developed and tested in 19 patients. Of all plasma concentrations measured, 70% were within the desired range of 2 to 4 micrograms/ml after the new method of lidocaine administration. Compared with other methods it is superior with respect to percent of time in the therapeutic range. No ventricular arrhythmias were evident, and no toxicities were associated with the new method. Infusions of lidocaine for more than 6 hr were associated with progressive increases in plasma concentrations that were higher (p less than 0.01) at 24 hr than at 6 hr.
Tattoo removal – state of the art (2007)

Tattooing has been around since the early beginnings of modern civilization. The discovery of selective photothermolysis at last has made it possible to remove tattoos without leaving a scar. Q-switched neodymium: yttrium-aluminum-garnet, alexandrite, and ruby lasers with pulse durations in the nanosecond domain fulfill this need. Argon or cw-CO(2) lasers as well as intense pulsed light sources should not be used since they often produce significant scarring. This article provides an overview of current laser systems. Developments leading to new tattoo inks, feedback systems to detect the absorbance characteristics of tattoo inks, dermal clearing agents, and perhaps even lasers with shorter pulse-durations might improve the results in the future.
Modulation of transcription by DNA supercoiling: a deletion analysis of the Escherichia coli gyrA and gyrB promoters. (1987)

Expression of the genes determining the subunits of Escherichia coli DNA gyrase (gyrA and gyrB) is known to be induced by relaxation of the template DNA. In this paper we report a deletion analysis of the gyrA and gyrB promoter regions. We find that a DNA sequence 20 base pairs long that includes the -10 consensus region, the transcription start point, and the first few transcribed bases is responsible for the property of induction by DNA relaxation. We propose a model for relaxation-stimulated transcription in which promoter clearance is the rate-limiting step.
Gametophytic competition in pearl millet, <i>Pennisetum typhoides</i> (Stapf et Hubb.) (1988)

Factors affecting reproductive strategies of pearl millet, which is currently classified as a predominantly allogamous species, were investigated. Gametophytic competition as well as the effect of growth temperature on this phenomenon were studied by means of the pollen mixture technique. The relative competitive ability of pollen from five different genetic stocks (Ligui, Massue, "Chinese," Thiotandé, 23d 2 B) was assessed by isozyme electrophoresis (esterase, alcohol dehydrogenase) of progeny plants. Gametophytic competition with a polygenic inheritance trend for pollen competitive ability is reported. A better competitive ability of autopollen on various types of allopollen was systematically found for the Ligui genotype. Temperature stress enhanced this trend. Hypotheses on the role of gametophytic competition in the evolution of the primary genetic pool of P. typhoides are discussed.Key words: pearl millet, pollen, competitive ability, segregation distortions.
Collaborative Mapping and Autonomous Parking for Multi-Story Parking Garage (2018)

We present a novel collaborative mapping and autonomous parking system for semi-structured multi-story parking garages, based on cooperative 3-D LiDAR point cloud registration and Bayesian probabilistic updating. First, an inertial-enhanced (IE) generalized iterative closest point (G-ICP) approach is presented to perform high accuracy registration for LiDAR odometry, which is loosely coupled with inertial measurement unit using multi-state extended Kalman filter fusion. Second, the IE G-ICP is utilized to reconstruct the 3-D point cloud model for each vehicle, and then the individual model maps are merged and updated into a global probabilistic 2-D grid map. A collaborative multiple layer semantic map is constructed to support autonomous parking. Finally, we propose a collaborative navigation approach for path planning when there are multiple vehicles in the parking garage through vehicle-to-vehicle communication. A global path planner is designed to explore the minimum cost path based on the semantic map, and local motion planning is performed using a random exploring algorithm for obstacle avoidance and path smoothing. Our pilot experimental evaluation provides a proof of concept for indoor autonomous parking by collaborative perception, map merging, and updating methodologies.
Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells (1994)

In order to clone novel diacylglycerol kinase (DGK) isozymes, we first obtained a DGK-related cDNA fragment by polymerase chain reaction using the human hepatoma cell line HepG2 mRNA and degenerated primers. The amplified fragment was subsequently used as a probe for screening the cDNA library from HepG2 cells. We obtained a cDNA clone coding for a novel DGK isozyme (designated DGK gamma) comprised of 791 amino acid residues. The amino acid sequence of DGK gamma was 52 and 62% identical to those of previously sequenced porcine 80-kDa and rat 90-kDa enzymes, respectively. DGK gamma, although initially cloned from the HepG2 cDNA libraries, was unexpectedly expressed in the human retina abundantly and to a much lesser extent in the brain. Other human tissues, including the liver and HepG2 cells, contained extremely low levels of DGK gamma mRNA. Furthermore, HepG2 cells and most of the human tissues except for the retina and brain expressed a truncated DGK gamma with an internal deletion of 25 amino acid residues (Ile451-Gly475). When transfected into COS-7 cells, the nontruncated cDNA gave phosphatidylserine-dependent DGK activity with no apparent specificity with regard to the acyl compositions of diacylglycerol. In contrast the truncated cDNA failed to give DGK activity in spite of the expression of its mRNA and enzyme protein in COS cells, thus demonstrating that the truncated DGK gamma is catalytically inactive. The sequence comparison of the three cloned DGKs revealed the presence of four highly conserved regions including the two sets each of EF-hand and zinc finger structures. Although the implication of the catalytically inactive form of DGK gamma remains unknown, this work further demonstrates the occurrence of multiple animal DGK isozymes with a conserved basic structure but with markedly different expression patterns depending on the cell types.
High-intensity treadmill training improves gait ability, VO2peak and cost of walking in stroke survivors: preliminary results of a pilot randomized controlled trial (2018)

Chronic stroke survivors should be encouraged to engage regular aerobic treadmill training at medium/high intensity. HITT is safe and feasible and has positive effects on gait ability, cardiovascular fitness and cost of walking in subjects with stroke in chronic phase.
Accurate Control of Multishelled ZnO Hollow Microspheres for Dye‐Sensitized Solar Cells with High Efficiency (2012)

A series of multishelled ZnO hollow microspheres with controlled shell number and inter-shell spacing have been successfully prepared by a simple carbonaceous microsphere templating method, whose large surface area and complex multishelled hollow structure enable them load sufficient dyes and multi-reflect the light for enhancing light harvesting and realize a high conversion efficiency of up to 5.6% when used in dye-sensitized solar cells.
Prospects for using risk scores in polygenic medicine (2017)

Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of complex traits and diseases, including neuropsychiatric disorders. Here, we consider the potential for translation to clinical use.
Three-dimensional structure of cofilin bound to monomeric actin derived by structural mass spectrometry data (2007)

The cytoskeletal protein, actin, has its structure and function regulated by cofilin. In the absence of an atomic resolution structure for the actin/cofilin complex, the mechanism of cofilin regulation is poorly understood. Theoretical studies based on the similarities of cofilin and gelsolin segment 1 proposed the cleft between subdomains 1 and 3 in actin as the cofilin binding site. We used radiolytic protein footprinting with mass spectrometry and molecular modeling to provide an atomic model of how cofilin binds to monomeric actin. Footprinting data suggest that cofilin binds to the cleft between subdomains 1 and 2 in actin and that cofilin induces further closure of the actin nucleotide cleft. Site-specific fluorescence data confirm these results. The model identifies key ionic and hydrophobic interactions at the binding interface, including hydrogen-bonding between His-87 of actin to Ser-89 of cofilin that may control the charge dependence of cofilin binding. This model and its implications fill an especially important niche in the actin field, owing to the fact that ongoing crystallization efforts of the actin/cofilin complex have so far failed. This 3D binary complex structure is derived from a combination of solution footprinting data and computational approaches and outlines a general method for determining the structure of such complexes.
Solubility and diffusivity data for the absorption of carbonyl sulfide, carbon dioxide, and nitrous oxide in amine solutions (1992)

Absorption data for COS and N,O in aqueous solutlons of N-methyldiethanolamine (MDEA), ethylene glycol, and sulfolane (tetrahydrothiophene 1,l-dioxide) at 298 K and solubility data for COS in water at temperatures ranging from 298 to 338 K are presented. Also density, viscosity, N,O solubility, and N,O dlffusivity data are reported for a wide range of aqueous aikanolamine solutions, aqueous mlxtures of alkanoiamines, and solutions of MDEA in water/ethanol. It is shown that an analogy between COS and N,O with respect to gas solubility in aqueous solutions of ethylene glycol and sulfolane holds up to about 25 mass %. This seems to justify, for engineering purposes, the application of this analogy for the estimation of COS solubilitles in diluted aqueous amine solutions. Direct verificatlon of a COS-N,O analogy was provided by absorption of N,O and COS into aqueous MDEA solutions in a laminar film reactor.
Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain (2012)

Despite increasing evidence of oxidative stress in the pathophysiology of autism, most studies have not evaluated biomarkers within specific brain regions, and the functional consequences of oxidative stress remain relatively understudied. We examined frozen samples from the cerebellum and temporal cortex (Brodmann area 22 (BA22)) from individuals with autism and unaffected controls (n=15 and n=12 per group, respectively). Biomarkers of oxidative stress, including reduced glutathione (GSH), oxidized glutathione (GSSG) and glutathione redox/antioxidant capacity (GSH/GSSG), were measured. Biomarkers of oxidative protein damage (3-nitrotyrosine; 3-NT) and oxidative DNA damage (8-oxo-deoxyguanosine; 8-oxo-dG) were also assessed. Functional indicators of oxidative stress included relative levels of 3-chlorotyrosine (3-CT), an established biomarker of a chronic inflammatory response, and aconitase activity, a biomarker of mitochondrial superoxide production. Consistent with previous studies on plasma and immune cells, GSH and GSH/GSSG were significantly decreased in both autism cerebellum (P<0.01) and BA22 (P<0.01). There was a significant increase in 3-NT in the autism cerebellum and BA22 (P<0.01). Similarly, 8-oxo-dG was significantly increased in autism cerebellum and BA22 (P<0.01 and P=0.01, respectively), and was inversely correlated with GSH/GSSG in the cerebellum (P<0.01). There was a significant increase in 3-CT levels in both brain regions (P<0.01), whereas aconitase activity was significantly decreased in autism cerebellum (P<0.01), and was negatively correlated with GSH/GSSG (P=0.01). Together, these results indicate that decreased GSH/GSSG redox/antioxidant capacity and increased oxidative stress in the autism brain may have functional consequence in terms of a chronic inflammatory response, increased mitochondrial superoxide production, and oxidative protein and DNA damage.
Manganese(II)-Containing MRI Contrast Agent Employing a Neutral and Non-Macrocyclic Ligand (2011)

The ligand N,N'-bis(2-pyridylmethyl)-bis(ethylacetate)-1,2-ethanediamine (debpn) coordinates divalent transition metal ions in either a pentadentate or hexadentate fashion. The coordination number correlates with the ionic radius of the metal ion, with larger cations being heptacoordinate as assessed by solid-state analysis. With Mn(II), the debpn ligand is hexadentate and remains bound to the oxophilic metal ion, even when dissolved in water. The ligand's incomplete coordination of the manganous ion allows water molecules to coordinate to the metal center. These two properties, coupled with the high paramagnetism associated with the S = 5/2 metal center, enable [Mn(debpn)(H(2)O)](ClO(4))(2) to serve as a stable and effective magnetic resonance imaging contrast agent despite the ligand's lack of both a macrocyclic component and an anionic charge.
Additional evidence for an eight-transmembrane-domain topology for <i>Caenorhabditis elegans</i> and human presenilins (1998)

Presenilins have been implicated in the genesis of Alzheimer's disease and in facilitating LIN-12/Notch activity during development. All presenilins have multiple hydrophobic regions that could theoretically span a membrane, and a description of the membrane topology is a crucial step toward deducing the mechanism of presenilin function. Previously, we proposed an eight-transmembrane-domain model for presenilin, based on studies of the Caenorhabditis elegans SEL-12 presenilin. Here, we describe experiments that support the view that two of the hydrophobic regions of SEL-12 function as the seventh and eighth transmembrane domains. Furthermore, we have shown that human presenilin 1 behaves like SEL-12 presenilin when analyzed by our methods. Our results provide additional experimental support for the eight-transmembrane-domain model of presenilin topology.
Murine thymic plasmacytoid dendritic cells (2003)

We report herein heterogeneous murine thymic cell subsets expressing CD11c and B220 (CD45R). The CD11c(+)B220(+) subset expresses Ly6C(high) and MHC class II(low) in contrast with previously described thymic DC (CD11c(+)B220(-) cells). Freshly isolated thymic CD11c(+)B220(+) cells show typical plasmacytoid morphology which differentiates to mature DC, in vitro with CpG oligodeoxynucleotides (ODN) 2216; we term this subset thymic plasmacytoid DC (pDC). These thymic pDC are highly sensitive to spontaneous apoptosis in vitro and induce low T cell allo-proliferation activity. Thymic pDC express low TLR2, TLR3 and TLR4 mRNA, normally found on human immature DC, and high TLR7 and TLR9 mRNA, normally found on human pDC. Thymic pDC also produce high amounts of IFN-alpha following culture with CpG ODN 2216 (TLR9 ligands) as compared with the previously defined thymic DC lineage which expresses low TLR9 mRNA and produce high IL-12 (p40) with CpG ODN 2216. These results indicate that thymic pDC are similar to IFN-producing cells as well as human pDC. The TLR and cytokine production profiles are consistent with a nomenclature of pDC. The repertoire of this cell lineage to TLR9 ligands demonstrate that such responses are determined not only by the quantity of expression, but also cell lineage.
Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: a conceptual challenge (1998)

Our results demonstrate that some nerve sheath tumours may contain histologically clear components of both neurofibroma and schwannoma, suggesting that (despite evident and well-defined clinicopathological differences) these two lesions may be even more closely related than previously recognized. Whether this phenomenon results from a localized microenvironmental change or from a clonal genetic alteration remains unknown.
Aroma Constituents of Soybean [Glycine max (L.) Merril] Milk Lacking Lipoxygenase Isoenzymes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAroma Constituents of Soybean [Glycine max (L.) Merril] Milk Lacking Lipoxygenase IsoenzymesAkio Kobayashi, Yohko Tsuda, Noriko Hirata, Kikue Kubota, and Keisuke KitamuraCite this: J. Agric. Food Chem. 1995, 43, 9, 2449–2452Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/jf00057a025https://doi.org/10.1021/jf00057a025research-articleACS PublicationsRequest reuse permissionsArticle Views547Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
특집 : 율곡학의 확산과 심화2 ; 율곡학파의 리기론 -리기 이해 문제를 중심으로 (2011)

이 논문은 율곡학파의 율곡 리기의 이해(분석) 방법을 살펴본 글이다. 분석의 대상은 시기적으로는 16세기에서 18세기까지, 구체적 인물로는 율곡 이이와 그의 적전으로 보기에 논란이 없는 우암 송시열, 수암 권상하, 남당 한원진을 선정하였으며, 그 분석 내용은 리기 이해에 국한시켰다. 먼저 율곡의 리기 이해를 분석하였으며, 그의 제자들이 그의 리기를 이해 방식이 어떻게 구체화하고 심층화시켰는지를 살펴보았다. 이 고찰을 통해서 살펴본 리기 이해의 변화는 율곡의 리기 이해를 원론으로 삼으면서도 그것을 다변화시켜 다각도로 설명하고 있었다. 그리고 이러한 변화는 리기론 자체의 발전만이 아니라 심성론의 심화로도 나타난다. 율곡과 그의 제자들은 리기를 이해하고 설명하는 것은 어렵다고 고백한다. 그리고 이러한 문제는 리기는 하나이면서 둘이요, 둘이면서 하나라는 주자학의 원론적 난제로부터 연유한다. 그럼에도 불구하고 그들은 이 문제를 설명하기 위해 리기를 다각도에서 접근하는 한편, 세분하여 분석적으로 설명하고 있다. 율곡학파의 리기 이해에서 주리와 주기는 한 단편의 이해일 뿐이었다. 이를 통해서 퇴계학파의 주리와 주기의 대립이라는 도식은 제한적으로만 가능할 뿐이라는 것도 부차적으로 확인할 수 있었다.
An electrical model for plasma armature voltage (1990)

Scaling of armature voltage with bore diameter is an important issue since it affects the predicted efficiency and the predicted velocity performance of proposed large-bore EM launchers. In this paper the experimental data for railguns with plastic/composite insulation is shown to fit a scaling relation of the form V{sub m} = V{sub e} + E(j)d, where the electric field dependence on current density is given by E(j) = E{sub 0} + J/{sigma}. This scaling relation predicts a linear increase in armature voltage with bore diameter for d > 0.1 m. The model is in better agreement with the limited data on large bore railguns than earlier models. 21 refs., 5 figs., 1 tab.
Effect of deposition time on structural, optical and morphological properties of facing-target sputtered TiO2 thin film (2015)

The aim of this work is to deposit nanocrystalline TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> films by DC reactive facing-target sputtering (FTS) technique. The TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> films have been deposited in Fluorine doped tin-oxide (FTO) glass substrate by FTS with sputtering pressure of 2.0 Pa, and Ar/O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gas ratio of 7:3. The main attraction of this paper is to correlate the structural, optical and morphological properties of these prepared TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> film with variation of deposition time (like 2, 4 and 12 hrs). The thickness of TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> film increases with the increase of deposition time. The correlation between the thickness variance and the structural, optical and morphological properties of TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin films has been investigated in details. From the results, it is cleared that the crystallinity, grain size and surface roughness enhance but cluster size reduces with the increase of deposition time. These prepared films have chanced to apply directly for dye-sensitized solar cell, photoelectrochemical cell and water splitting applications.