gebhart/patrepeval huggingface dataset:
Functional proteomics of nonalcoholic steatohepatitis: Mitochondrial proteins as targets of <i>S</i> -adenosylmethionine (2003)

Recent work shows that S-adenosylmethionine (AdoMet) helps maintain normal liver function as chronic hepatic deficiency results in spontaneous development of steatohepatitis and hepatocellular carcinoma. The mechanisms by which these nontraditional functions of AdoMet occur are unknown. Here, we use knockout mice deficient in hepatic AdoMet synthesis (MAT1A(-/-)) to study the proteome of the liver during the development of steatohepatitis. One hundred and seventeen protein spots, differentially expressed during the development of steatohepatitis, were selected and identified by peptide mass fingerprinting. Among them, 12 proteins were found to be affected from birth, when MAT1A(-/-) expression is switched on in WT mouse liver, to the rise of histological lesions, which occurs at approximately 8 months. Of the 12 proteins, 4 [prohibitin 1 (PHB1), cytochrome c oxidase I and II, and ATPase beta-subunit] have known roles in mitochondrial function. We show that the alteration in expression of PHB1 correlates with a loss of mitochondrial function. Experiments in isolated rat hepatocytes indicate that AdoMet regulates PHB1 content, thus suggesting ways by which steatohepatitis may be induced. Importantly, we found the expression of these mitochondrial proteins was abnormal in obob mice and obese patients who are at risk for nonalcoholic steatohepatitis.
Fiber-optic sensing of voltages by line integration of the electric field (1989)

A fiber-optic sensor that is sensitive to the line integral of the electric field is presented. The sensor detects electric-potential differences by adding the scalar products of the local electric fields along the integration path times the path-segment vectors. This is achieved by exploiting symmetry properties of the converse piezoelectric effect. The sensor principle is experimentally demonstrated. Important performance parameters including integration accuracy, dynamic range, linearity, and bandwidth are examined.
(Tl, Pb, Bi)Sr2Ca2Cu3O<i>z</i> superconductors with zero resistance at 120 K (1990)

We have synthesized new superconductors of nearly single phase with zero-resistance temperatures around 120 K employing a novel method for sintering. The samples included a nominal composition of (Tl0.64Pb0.2Bi0.16)Sr2Ca3Cu4Oz. This sample was prepared from the mixture of presynthesized (Tl0.64Pb0.2Bi0.16)Sr2CaCu2Oz (1212 phase), CaO, and CuO powders. The mixed powder was sintered at 920 °C in O2 gas and post-annealed at 400–600 °C in O2 gas. The powder x-ray diffraction revealed that the sample was isostructural with the Tl-based (Tl, Pb, Bi)Sr2Ca2Cu3Oz (1223 phase). The sample exhibited a sharp superconducting transition at Tonsetc=125 K and TR=0c=120 K and the superconducting diamagnetic signal at 10 K was about 20% of a full Meissner effect.
Signaling through NO and cGMP‐dependent protein kinases (2003)

The gaseous molecule nitric oxide (NO) modulates a large variety of physiological functions including vascular tone, intestinal motility, platelet aggregation, proliferation, apoptosis, and neurotransmission. NO initiates diverse cellular signaling cascades which comprise nitrosylation of proteins, adenosine 5'-diphosphate (ADP)-ribosylation, or stimulation of soluble guanylyl cyclases which catalyze intracellular guanosine 3',5'-cyclic monophosphate (cGMP) synthesis. cGMP activates cGMP-dependent protein kinases (cGK) which mediate localized and global signaling. Furthermore, cGMP regulates the activity of phosphodiesterases (PDE) which modulate the duration and amplitude of cyclic nucleotide signaling. Two different types of cGK are expressed in mammals, cGKI and cGKII. Activation of the NO/cGMP/cGKI pathway induces relaxation of smooth muscle by lowering the cytosolic calcium level and/or by calcium desensitization of the contractile elements.
Laser-cooling limits and single-ion spectroscopy (1987)

The limitations to the achievement of low kinetic energies for laser cooling of single ions confined in electromagnetic traps are discussed. Sideband cooling of an ion in an rf (Paul) trap is reexamined including the effects of finite laser bandwidth and the energy of the rf micromotion. The micromotion is the oscillatory motion of the ion at the same frequency as the rf voltage applied to the trap electrodes. Sideband cooling of ions in a Penning trap is examined for the first time. In both cases, cooling to the zero-point energy of the ion in the trap should be possible and a method for verifying this condition is suggested. The implications for high-resolution, high-accuracy spectroscopy are investigated. Under certain conditions, the uncertainty in the second-order Doppler shift may be significantly less than 1 part in ${10}^{18}$. .AE
Estrogenic Activity of the Phytoestrogens Naringenin, 6-(1,1-Dimethylallyl)naringenin and 8-Prenylnaringenin (2002)

Chemically synthesized naringenin derivatives, identical to natural occurring compounds, were tested for their estrogenic activity using two independent estrogen screening assays. Using a yeast based estrogen receptor assay, strong estrogenic activities were demonstrated for 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin, while the parent compound naringenin did not show recognizable estrogenic activity. In MVLN cells, a bioluminescent MCF-7-derived cell line, the estrogenic activity of 8-prenylnaringenin and 6-(1,1-dimethylallyl)naringenin was detected at concentrations of 10(-6) M and 5 x 10(-6) M respectively. Naringenin demonstrated estrogenic activity but only at a concentration of 10(-5) M. These estrogenic effects are mediated by the ER, as the antiestrogen 4-hydroxytamoxifen inhibited these activities. In summary, this study provides the further confirmation that 8-prenylnaringenin demonstrates high estrogenic activity, and demonstrated for the first time for 6-(1,1-dimethylallyl)naringenin a reasonable high estrogenic activity, while naringenin exhibit low or no estrogenic activity.
A Simplified Method for the 3D Printing of Molecular Models for Chemical Education (2017)

Using tangible models to help students visualize chemical structures in three dimensions has been a mainstay of chemistry education for many years. Conventional chemistry modeling kits are, however, limited in the types and accuracy of the molecules, bonds and structures they can be used to build. The recent development of 3D printing technology has allowed a much wider variety of molecules to be created for teaching but is not simple to do. Creating the files needed to print molecular structures is often technically difficult and requires the use of multiple software programs, which are not always user-friendly. Not all educators or students have the resources or technical skill to create such files and so are put off trying to use 3D printing in the classroom. Here we demonstrate a simple method to easily generate the files needed for the 3D printing of almost any molecule using the National Institutes of Health Print Exchange server (or simple alternatives). The basic molecule structure may be created in-house or easily sourced online from databases such as UniProt or PubChem. The options for quickly and cheaply printing such structures in a range of materials using online and local stores, as well as in-house 3D printers, are explored and a simple protocol is described. The method brings 3D printing to a wider audience, thus helping to spread its use in chemical pedagogy, and may also be used in self-directed learning exercises by students themselves.
On The Performance Of Standard-Independent I/Q Imbalance Compensation In Ofdm Direct-Conversion Receivers (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
Cross sectional measurements of dense high aspect ratio patterns using CD-SAXS (2005)

Developing non-destructive, high precision characterization methods of pattern cross section is critical to the maturation of sub-65 nm technologies. In this study, Criticial Dimension Small Angle X-ray Scattering (CD-SAXS) data are used to non-destructively characterize the dimensions of dense, high aspect ratio patterns with sub-nm precision. Data are presented for a series of photoresist patterns with varying degrees of footer and sidewall angle. The scattering intensity, I, is measured as a function of the scattering vector, q, and the sample rotation angle, w. The resulting data are transformed to an effective Qx-Qz plane, representing the Fourier transform of the average pattern cross section. From this data, complex features of cross sectional shape can in principle be obtained through systematic analysis of appropriate intensity slices. Here, we demonstrate the protocol for high precision measurements using CD-SAXS. Data are analyzed to extract average values of pitch, line width, line height, sidewall angle, and the size of a foot or undercut. In addition, the ability of the technique to analyze more complex features, such as lines with curved sidewalls and corner rounding, is discussed. The CD-SAXS technique is found to provide dimensions with sub-nm precision and sidewall angles with sub-degree precision in a non-destructive manner, providing an option for characterization of next generation microelectronic and nanofabricated structures.
Reservoir Drainage with Downhole Permanent Monitoring and Control Systems. Real-Time Integration of Dynamic Reservoir Performance Data and Static Reservoir Model Improves Control Decisions (2000)

Abstract Downhole Permanent Monitoring and Control Systems invoke the vision of adapting real-time process control to the hydrocarbon drainage process. This paper discusses some aspects of the evolution towards that vision. Three functions of Reservoir Management are focused: Estimating physical downhole states (inverse problems) for Reservoir CharacterizationUpdating models (history matching)Controlling well inflow The potential for a real-time system to contribute successfully seems to differ from function to function.
Regio- and diastereoselective reactions of dithio-substituted crotyllithium and aldehydes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegio- and diastereoselective reactions of dithio-substituted crotyllithium and aldehydesJim Min Fang, Li Fan Liao, and Ber Cherng HongCite this: J. Org. Chem. 1986, 51, 14, 2828–2829Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/jo00364a045https://doi.org/10.1021/jo00364a045research-articleACS PublicationsRequest reuse permissionsArticle Views228Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hydropyrolysis of high molecular weight organic matter in Murchison (2003)

Hydropyrolysis of the Murchison macromolecular material releases polyaromatic compounds including phenanthrene, carbazole, fluoranthene, pyrene, chrysene, perylene, benzoperylene and coronene units with varying degrees of alklyation.
Multiscale two-view stereo using convolutional neural networks for unrectified images (2017)

Two-view stereo problem is a well researched problem in 3D computer vision. Algorithms proposed in the past have focused on rectified stereo images where the epipolar lines are parallel to the horizontal axis. The general problem of computing stereo correspondences for unrectified images without any knowledge of calibration parameters is an important problem but unexplored as yet. Our idea in this paper is to predict depth maps from two unrectified stereo images using a modified Flownet architecture. Since, datasets for depth map reconstruction for unrectified stereo images for deep learning do not exist, we have created a dataset of turn table sequences of 3D models from Google 3D warehouse. Following the concepts of Attention modelling, we implement an architecture for combining correlations computed at multiple resolutions using a simple element-wise multiplication of the correlations to aid the architecture to resolve correspondences for textureless and repeated textured surfaces. Our experiments show both qualitaitve and quantitative improvements of depth maps over the original Flownet architecture.
Real-time multimedia network system using VLIW hardware stack processor (2002)

We propose a multimedia network system using VLIW hardware stack processors, which supports mainly the presentation layer of OSI protocol and fits various real-time applications including intelligent processing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
SimulFluor Respiratory Screen for Rapid Detection of Multiple Respiratory Viruses in Clinical Specimens by Immunofluorescence Staining (2000)

A new rapid direct immunofluorescence assay (DFA) respiratory screen reagent for detection of seven common respiratory viruses (respiratory syncytial virus [RSV], influenza A and B viruses, parainfluenza virus types 1 to 3, and adenovirus) was compared with standard single or dual DFA reagents and culture. In total, 1,531 respiratory samples were adequate for testing with both SimulFluor Respiratory Screen (RS) reagent (Chemicon International, Temecula, Calif.) and single or dual DFA reagents. The RS DFA reagent detected 367 (98.4%) and single or dual DFA reagents detected 368 (98.7%) of 373 DFA-positive samples. In addition, the RS DFA reagent was equivalent to or better than culture for detection of all viruses except adenovirus. Only 15 of 799 (1.9%) RS-negative samples inoculated into cell cultures yielded respiratory virus isolates (one RSV, five influenza A virus, two influenza B virus, one parainfluenza virus, and six adenovirus). Sixty-six other virus isolates (13 rhinovirus, 24 cytomegalovirus, 28 herpes simplex virus type 1, and 1 enterovirus) were also recovered in culture. With cytospin preparation of slides, only 7.5% of samples submitted were deemed inadequate for DFA. The availability of a rapid DFA screening reagent for detection of multiple common respiratory viruses within 1 to 2 h of sample collection should be of great benefit in terms of patient management and infection control.
Premalignant Cervical Lesions Are Characterized by Dihydrofolate Reductase Gene Amplification and c-Myc Overexpression (2007)

c-Myc protein levels were elevated in CIN 1, 2, and 3 (p = .02) biopsies. Concomitantly, DHFR gene amplification was detected in CIN 1, 2, and 3 (p = .0001). The degrees of DHFR gene amplification and of c-Myc protein levels were a measure of the progressive degree of the lesion.
[Effect of fasting-dietary therapy in patients with arterial hypertension and obesity]. (2010)

35 patients with arterial hypertension and obesity against the background of fasting-diet therapy and after 1 and 6 months after treatment conducted daily monitoring of blood pressure, microalbuminuria and glomerular filtration rate, the study of color and contrast sensitivity of retinal eyes. Fasting-diet therapy within 11 days results in reliable reduced daily average AD and stabilization of load pressure indicators; reduction originally pathological microalbuminurii at 18%, increase in the number of patients with normal speed glomerular filtering 48%; improving of eyes function, these changes are saved within 1-6 months after treatment without the using of antihypertensive therapy.
Laser Pulse Formatting to Reduce Thermal Blooming by Aerosol Vaporization (1989)

Abstract : Propagation of ground-based, high-energy laser (HEL) beams through the atmosphere at a laser wavelength of lambda(L) = 1.06 microns is limited by thermal blooming due to aerosol absorption. The scaling of critical laser power with beam diameter requires that the aperture size exceed 20 m for average laser powers of 100 MW. SRL has shown that this problem may be resolved by vaporizing the aerosols with a laser for aerosol vaporization (LAV). The dependence of vaporization on fluence and wavelength has been determined. In particular, it is shown that a LAV wavelength lambda(nu) = 1.06 microns and intensity of 10 MW/sq cm yields a reduction by a factor of 5 at 2 microsec, corresponding to 20 J/sq cm of laser fluence per pulse. The best LAV wavelength appears to be that of a KrF laser, lambda(nu) = 0.248 microns. For this wavelength, an intensity of 3 MW/sq cm and a pulse duration of 1 microsec, corresponding to a fluence of 3 J/sq cm per pulse, reduces aerosol absorption by a factor of 50. The dependence of the critical HEL power on the beam aperture diameter d has been determined in the presence and absence of LAV, assuming no wind shear. Without vaporization the scaling law is pessimistic - on can propagate less than 10 MW average power at d = 10 m. If one uses a KrF LAV at an average power of 2 MW, a pulsewidth of 1 microsec, and a pulse repetition frequency of 10 Hz, the critical power at d = 5 m is 100 MW. This greatly alleviates the thermal blooming problem.
DFT study of polarizabilities and dipole moments of water clusters (2004)

Abstract Density functional theory (DFT) calculations with different exchange‐correlation functionals, Becke's three‐parameter exchange functional and the gradient‐corrected functional of Lee, Yang, and Paar (B3LYP) and Becke's three‐parameter functional with Perdew–Wang correlational functional (B3PW91), are performed to study the dielectric properties of small and medium‐sized water clusters. For these H‐bonded systems, we optimize the geometries and compute the dipole moments and polarizabilities using a supermolecule approach. The corresponding properties of the individual water molecules in the clusters are extracted from the molecular properties using the Hirshfeld expansion of the electronic density. Calculations at Hartree–Fock and second‐order Møller–Plesset (MP2) levels are also presented for a comparison with the DFT results. The dependence of the dielectric properties on the cluster structure and size is given for both clusters and individual molecules and is compared with the available experimental data. The intermolecular interactions and their influences on the dielectric properties are discussed. The current results could serve to improve existing polarizable force fields for water. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2005
Epidemiology, genetics and management of psoriatic arthritis 2013: focus on developments of who develops the disease, its clinical features, and emerging treatment options (2013)

Abstract: The picture of elements comprising the genetic susceptibility to develop psoriatic arthritis, especially those involving human leukocyte antigen alleles, is emerging in much greater clarity because of improvements in the methods of psoriatic arthritis ascertainment and in the technology of genetic typing. This new knowledge suggests there is genetic heterogeneity in the psoriasis phenotype, and that there are several genetically and clinically different forms of psoriatic arthritis. These genetic studies on psoriatic arthritis further reinforce the relationship of psoriatic arthritis to the other spondyloarthritides, but also raise novel questions of whether the effect of certain susceptibility genes may differ among them. Considerable evidence indicates that the clinical features reflect a CD8 T lymphocyte-driven immune response is present that is characterized by clonal expansion and differentiation towards memory-effector phenotypes. With the aid of new classification criteria, the typical clinical features of psoriatic arthritis involving different joints, entheses, and their related compartments are being better defined as distinctive characteristics of psoriatic arthritis or of the spondyloarthritis group of disorders. In the evaluation of an individual with psoriatic arthritis, taking a patient-focused perspective is recommended, which has the potential to enhance their quality of life significantly. The choice of current and emerging therapeutic agents from an increasing realm of conventional and biologic agents is becoming much better rationalized and more firmly based on evidence from clinical trials. Keywords: psoriatic arthritis, genetic susceptibility, heterogeneity, classification, diagnostic criteria, treatment
TOWARDS 4D VIRTUAL CITY RECONSTRUCTION FROM LIDAR POINT CLOUD SEQUENCES (2013)

Abstract. In this paper we propose a joint approach on virtual city reconstruction and dynamic scene analysis based on point cloud sequences of a single car-mounted Rotating Multi-Beam (RMB) Lidar sensor. The aim of the addressed work is to create 4D spatio-temporal models of large dynamic urban scenes containing various moving and static objects. Standalone RMB Lidar devices have been frequently applied in robot navigation tasks and proved to be efficient in moving object detection and recognition. However, they have not been widely exploited yet for geometric approximation of ground surfaces and building facades due to the sparseness and inhomogeneous density of the individual point cloud scans. In our approach we propose an automatic registration method of the consecutive scans without any additional sensor information such as IMU, and introduce a process for simultaneously extracting reconstructed surfaces, motion information and objects from the registered dense point cloud completed with point time stamp information.
Agora: Enhancing Group Awareness and Collaboration in Floristic Digital Libraries. (1998)

. Digital libraries can be regarded as virtual spaces in which collaborative scholarly research can be conducted. Floristic digital libraries provide such collaboration spaces for scientists working on solutions for Earth&apos;s biodiversity problems. However, group awareness and collaboration are not easily achieved in an increasingly distributed environment such as the virtual space in which digital library users (particularly botanists and biologists) do their work. We describe an environment that enables group awareness, communication, and collaboration among users in a globally accessible floristic digital library. This is achieved by extending existing library facilities with recommendation and alerting services, as well as various communication interfaces. Keywords: Recommendation services, group awareness, agents, floristic digital libraries. 1. Introduction Digital libraries comprise highly complex and dynamic information spaces on top of which a variety of services are provide...
Wavelength-selective addressing of visible and near-infrared plasmon resonances for SU8 nanolithography (2011)

We imprint plasmonic near field enhancements as nanoscale topography in SU8 photoresist using two-photon absorption from a spectrally filtered broadband supercontinuum light source. Imprinted patterns smaller than 50 nm across are obtained localized at positions of high local field enhancements in gold bow tie antennas, and gold split rings resonant in the visible and near-infrared. Enhanced exposure only occurs at wavelengths and polarizations that exactly match the plasmonic resonances. Hence our work demonstrates that wavelength selective addressing of hot spots for nanolithography using an inexpensive, low peak-power picosecond pulsed source is freely tunable throughout the visible and infrared to match any desired plasmon resonance.