gebhart/patrepeval huggingface dataset:
In Vitro Studies of Antiphospholipid Antibodies and Its Cofactor, β2-Glycoprotein I, Show Negligible Effects on Endothelial Cell Mediated Protein C Activation (1991)

The effect of sera and purified IgG isolated from plasma of 46 patients with systemic lupus erythematosus (SLE) and 9 healthy donors on the endothelial cell (EC) mediated protein C activation was investigated. Out of the 46 SLE sera used, 19 were antiphospholipid antibodies (aPL) positive. From 12 patients IgG was isolated, of which 6 contained aPL. EC were first incubated with IgG (7 mg/ml) or serum (1:1 diluted) for 1 h and then tested for their ability to promote protein C activation by thrombin, with the cells either in a monolayer or in a suspension. The normal range (mean of control values +/- 2 SD) of protein C activation was 80-120%. In contrast to others, we could not detect an inhibition of protein C activation by any of the patient IgG's or sera. The recently described cofactor for binding of antiphospholipid antibodies to phospholipids, beta 2-glycoprotein I, was purified and added to the purified IgG's. A combination of these two components did not inhibit the EC mediated protein C activation by thrombin. This study suggests that the inhibition of the protein C activation, mediated by EC, is not a general mechanism by which aPL related thrombosis can be explained.
Integrated micro optical flying head with lens positioning actuator for small form factor data storage (2004)

An integrated MEMS optical flying head(OFH) is presented for a small form factor with high-density portable data storage. It is composed of a high numerical-aperture(NA) objective lens, a micro lens actuator for adjusting the position of the lens, an integrated air-bearing-slider(ABS), and an embedded magnetic-field-modulation(MFM) coil for magneto-optical recording. For adjusting the optimal focal length of the lens, a vertical comb-driven actuator and a parallel plate actuator are adopted. In addition, the area-optimized torsion spring is used for vertical actuation. The ABS structure and the double layer MFM coil are fabricated on a transparent substrate bonded to the silicon actuator. The overall size of the integrated MEMS OFH assembled with the high NA(0.85) objective lens is 3 mm? 1.6 mm? 0.5 mm(in length? width? thickness), which makes it suitable for a portable optical storage device.
Efficient subgraph-based sampling of Ising-type models with frustration (2014)

Here is proposed a general subgraph-based method for efficiently sampling certain graphical models, typically using subgraphs of a fixed treewidth, and also a related method for finding minimum energy (ground) states. In the case of models with frustration, such as the spin glass, evidence is presented that this method can be more efficient than traditional single-site update methods.
Global Analysis of <i>Escherichia coli</i> Gene Expression during the Acetate-Induced Acid Tolerance Response (2001)

The ability of Escherichia coli to survive at low pH is strongly affected by environmental factors, such as composition of the growth medium and growth phase. Exposure to short-chain fatty acids, such as acetate, proprionate, and butyrate, at neutral or nearly neutral pH has also been shown to increase acid survival of E. coli and Salmonella enterica serovar Typhimurium. To investigate the basis for acetate-induced acid tolerance in E. coli O157:H7, genes whose expression was altered by exposure to acetate were identified using gene arrays. The expression of 60 genes was reduced by at least twofold; of these, 48 encode components of the transcription-translation machinery. Expression of 26 genes increased twofold or greater following treatment with acetate. This included six genes whose products are known to be important for survival at low pH. Five of these genes, as well as six other acetate-induced genes, are members of the E. coli RpoS regulon. RpoS, the stress sigma factor, is known to be required for acid tolerance induced by growth at nonlethal low pH or by entry into stationary phase. Disruption of the rpoS gene by a transposon insertion mutation also prevented acetate-induced acid tolerance. However, induction of RpoS expression did not appear to be sufficient to activate the acid tolerance response. Treatment with either NaCl or sodium acetate (pH 7.0) increased expression of an rpoS::lacZ fusion protein, but only treatment with acetate increased acid survival.
Aptamer Modified Organic–Inorganic Hybrid Silica Monolithic Capillary Columns for Highly Selective Recognition of Thrombin (2012)

A novel kind of aptamer modified organic-inorganic hybrid silica monolithic capillary column has been developed, via the covalent bonding of 5'-NH(2)-modified aptamer for human α-thrombin on hybrid silica monolith, prepared by sol-gel method, with tetraethoxysilane and 3-aminopropyltriethoxysilane as precursors. Due to the large specific surface area of the hybrid matrix, the average coverage density of aptamer reached 568 pmol/μL, and the thrombin binding capacity was 1.15 μg/μL, 14 times higher than that of aptamer modified open tubular capillaries. By such an affinity capillary column, the limit of detection of thrombin was decreased to 3.4 nM with a UV detector. Furthermore, even when thrombin was mixed with 1000 times more concentrated human serum, it could be selectively enriched and detected with the signal-to-noise ratio as ca.10. These results indicate that the developed preparation strategy for aptamer based hybrid silica monolithic capillary column might provide an effective method to achieve highly selective recognition of trace targets.
Response to a sudden unexpected stimulus. (1926)

The response to a sudden unexpected stimulus is conditioned not only by the nature of the stimulus itself, but also by the preceding general state of muscular tonus. When an individual is extremely relaxed a sudden loud stimulus causes little or no start and seems to lose its irritating character; while the same kind of stimulus, when an individual is in a state of muscular tenseness, will bring about a start and very considerable muscular contraction. (PsycINFO Database Record (c) 2012 APA, all rights reserved)
Vibrational circular dichroism of optically active cyclopropanes. 3. trans-2-Phenylcyclopropanecarboxylic acid derivatives and related compounds (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVibrational circular dichroism of optically active cyclopropanes. 3. trans-2-Phenylcyclopropanecarboxylic acid derivatives and related compoundsSritana C. Yasui and Timothy A. KeiderlingCite this: J. Am. Chem. Soc. 1987, 109, 8, 2311–2320Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/ja00242a012https://doi.org/10.1021/ja00242a012research-articleACS PublicationsRequest reuse permissionsArticle Views382Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Stem Cell Source (2009)

Hematopoietic progenitor cell (HPC) products contain hematopoietic stem and lineage-committed progenitor cells capable of providing hematopoietic and immune reconstitution after myeloablative or reduced-intensity preparative regimens. There is no unanimity on the terminology.
Traditional healers, HIV outcomes, and mortality among people living with HIV in Senegal, West Africa (2019)

Traditional healer use is common among people living with HIV in Senegal and is associated with advanced disease and increased mortality. Partnering with traditional healers may be an effective strategy to improve the HIV care cascade and decrease mortality in the region.
Distinction between 5‐bromodeoxyuridine labeled and unlabeled mitotic cells by flow cytometry (1983)

Exponentially growing Friend leukemia cells are exposed to 5-bromodeoxyuridine (BrdUrd) for the time period equivalent to one generation. After fixation and incubation with RNase, DNA in situ is partially denatured by acid and the cells are stained with acridine orange (AO). Staining with AO under these conditions reveals the extent of denatured versus double stranded DNA and enables one to distinguish mitotic from interphase cells. It is observed that all BrdUrd treated cells, regardless of cell cycle phase, have decreased both green and red fluorescence. This finding suggests that BrdUrd interacts with AO not only in the complexes of the dye with double stranded DNA, but also with the single stranded biopolymer. The BrdUrd-attributed suppression of cell fluorescence is large enough to separate totally BrdUrd labeled from unlabeled mitotic populations. The combination of these two flow cytometric techniques, one which allows discrimination between interphase and metaphase cells and the other which allows further subdivision of metaphase cells into those which have incorporated BrdUrd and those which have not, provides an alternative to the autoradiographic procedure necessary for obtaining the fraction of labeled mitoses.
Design and implementation of a closed-loop blood glucose control system in patients with type 1 diabetes (2013)

In the work presented in this dissertation, open-loop and closed-loop control strategies that were aimed at resolving major glucose control problems in the postprandial period were developed. A new model-based control algorithm for postprandial glucose regulation in open-loop, which is based on set-inversion technology, was developed. It automatically and efficiently coordinates the values of basal-bolus insulin to achieve certain predefined control objectives. The algorithm was designed to enable integration into existing smart insulin pumps. Closed-loop control strategies based on sliding mode techniques and insulin-on-board constraints were implemented to reduce the risk of late hypoglycaemic events and to obtain safer controller performance without increasing the period of hyperglycaemia. Extensive evaluation and validation of the control robustness was performed in a comprehensive virtual environment that was specifically designed and implemented to facilitate realistic simulations. A practical methodology to “virtualise” a cohort of real Type 1 diabetic patients was also developed
Treatment of psoriasis with oral liarozole: a dose‐ranging study (2000)

The data confirm that liarozole is an effective treatment for psoriasis and indicate that the lowest effective dose is 75 mg twice daily. The drug seems generally to be well tolerated.
Effect of short-term treatment with low dosages of the proton-pump inhibitor omeprazole on serum chromogranin A levels in man (2004)

BACKGROUND: Measurement of chromogranin A (CgA) levels in blood can be used to monitor neuroendocrine tumors (NETs). CgA levels may also be elevated in several other endocrine and non-endocrine diseases. It is well known that drugs affecting acid gastric secretion can increase gastrin. Proton-pump inhibitors are extensively used but only a few data have been reported on their effects on CgA secretion. DESIGN: The aim of the study was to evaluate the short-term effect of low dosages of omeprazole (OM) on CgA levels and to sensitize endocrinologists to possible false positive values of CgA in order to prevent expensive diagnostic work-up in searching for NETs. SUBJECTS AND METHODS: Thirty-five female and nine male in-patients (18-81 years) were studied. Mild or severe hypertension in 20 patients needed therapy. Endocrine and metabolic diseases were diagnosed in the majority of patients. CgA levels were evaluated before and during OM therapy (10 mg/day, orally). RESULTS: Without OM therapy, CgA levels were 64+/-6 microg/l. Elevated baseline CgA levels were found in nine subjects. CgA levels were significantly related to age (P<0.001), creatinine levels (P=0.03) and the severity of hypertension (P=0.002). On short-term OM therapy (n=42; 18.8+/-2.4 days; range 5-90 days) a significant (P<0.001) increase in CgA (145+/-22 microg/l) from baseline (63+/-7 microg/l) levels was found. The average net CgA increase on short-term OM therapy was 93+/-20 microg/l. There was a significant correlation between baseline CgA levels and CgA increase on short-term OM therapy (P=0.004) but not between the increase in CgA and the duration of the therapy. CONCLUSIONS: An increase in CgA levels quickly follows the start of low dosages of OM. This release is more pronounced when the baseline CgA levels are already increased by slight renal insufficiency or severe hypertension. In this common clinical situation an intensive work-up for NETs is not justified before reassessment of CgA after the withdrawal of OM.
Phase Retrieval from Defocused Images and Its Applications in Lithography (1997)

This paper discusses the application of iterative phase retrieval method to phase measurement in optical lithography. A simple algorithm was developed for reconstructing phase information from image intensity distributions measured under different defocus conditions. The phase distribution in the image plane and in the pupil plane are reconstructed from the images obtained using the micro-lithography simulation microscope, MSM100 (Zeiss). Two applications of this method in optical lithography meteorology were investigated. First, the phase transmission of phase-shifting masks was successfully measured both for alternating and for attenuating type masks. The reconstructed phase showed that the uniform background of light leaking from the opaque regions on the mask can affect the phase in the image plane. Second, the possibility of using this method in measuring aberrations of projection optics was examined.
The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and meta-analysis (2012)

The review found evidence for the involvement of the γ-glutamyl cycle and trans-sulphuration pathway in autistic disorder is sufficiently consistent, particularly with respect to the glutathione redox ratio, to warrant further investigation to determine the significance in relation to clinical outcomes. Large, well designed intervention studies that link metabolites, cofactors and genes of the γ-glutamyl cycle and trans-sulphuration pathway with objective behavioural outcomes in children with autism spectrum disorders are required. Future risk factor analysis should include consideration of multiple nutritional status and metabolite biomarkers of pathways linked with the γ-glutamyl cycle and the interaction of genotype in relation to these factors.
[Social phobia: clinical and therapeutic approach]. (1995)

Although social phobia is a real pathological condition, it has often been neglected. In fact, social phobia is among the least studies of the major anxiety disorders. This is quite surprising, as approximately 2% of the population suffer from debilitating social phobia with devastating effects on career and quality of life, and as this disorder can now be considered as a treatable condition. After defining social phobia, the authors will describe the prevalence, clinical features and etiology of social phobia. Effective psychopharmacological and psychological treatments of social phobia will also be reviewed. The drugs that have been most studied are monoamine oxidase inhibitors and beta-blockers. Several controlled studies have also concluded that behavioral and cognitive therapies (exposure in vivo therapy, social skills training, cognitive restructuring) are beneficial for social phobics. The combination of psychopharmacotherapy and psychological interventions also seems promising. Finally, as it is necessary to distinguish among various subtypes of social phobia, further studies will have to investigate whether specific subtypes do better or worse with specific treatments.
Anti-inflammatory Effects of Polyphenolic-Enriched Red Raspberry Extract in an Antigen-Induced Arthritis Rat Model (2011)

The red raspberry ( Rubus idaeus ) fruit contains bioactive polyphenols including anthocyanins and ellagitannins with reported anti-inflammatory properties. This study sought to investigate the cartilage-protecting and anti-inflammatory effects of a polyphenolic-enriched red raspberry extract (RRE; standardized to total polyphenol, anthocyanin, and ellagitannin contents) using (1) an in vitro bovine nasal explant cell culture model and (2) an in vivo adjuvant-induced arthritis rat model. RRE contained 20% total polyphenols (as gallic acid equivalents), 5% anthocyanins (as cyanidin-3-glucoside equivalents), and 9.25% ellagitannins (as ellagic acid equivalents). In the in vitro studies, bovine nasal explants were stimulated with 10 ng/mL IL-1β to induce the release of proteoglycan and type II collagen. On treatment with RRE (50 μg/mL), there was a decrease in the rate of degradation of both proteoglycan and type II collagen. In the in vivo antigen-induced arthritis rat model, animals were gavaged daily with RRE (at doses of 30 and 120 mg/kg, respectively) for 30 days after adjuvant injection (750 μg of Mycobacterium tuberculosis suspension in squalene). At the higher dose, animals treated with RRE had a lower incidence and severity of arthritis compared to control animals. Also, histological analyses revealed significant inhibition of inflammation, pannus formation, cartilage damage, and bone resorption by RRE. This study suggests that red raspberry polyphenols may afford cartilage protection and/or modulate the onset and severity of arthritis.
Arterial Stiffness Is Associated With Regional Ventricular Systolic and Diastolic Dysfunction (2007)

Arterial stiffness is associated with early and asymptomatic impairment of systolic as well as diastolic myocardial function. Further studies are needed to elucidate role of vascular compliance in the development of ventricular dysfunction and failure.
Describing small-scale structure in random media using pulse-echo ultrasound (1990)

A method for estimating structural properties of random media is described. The size, number density, and scattering strength of particles are estimated from an analysis of the radio frequency (rf) echo signal power spectrum. Simple correlation functions and the accurate scattering theory of Faran [J.J. Faran, J. Acoust. Soc. Am. 23, 405-418 (1951)], which includes the effects of shear waves, were used separately to model backscatter from spherical particles and thereby describe the structures of the medium. These methods were tested using both glass sphere-in-agar and polystyrene sphere-in-agar scattering media. With the appropriate correlation function, it was possible to measure glass sphere diameters with an accuracy of 20%. It was not possible to accurately estimate the size of polystyrene spheres with the simple spherical and Gaussian correlation models examined because of a significant shear wave contribution. Using the Faran scattering theory for spheres, however, the accuracy for estimating diameters was improved to 10% for both glass and polystyrene scattering media. It was possible to estimate the product of the average scattering particle number density and the average scattering strength per particle, but with lower accuracy than the size estimates. The dependence of the measurement accuracy on the inclusion of shear waves, the wavelength of sound, and medium attenuation are considered, and the implications for describing the structure of biological soft tissues are discussed.
Infections Due to<i>Haemophilus influenzae</i>Serotype E: Microbiological, Clinical, and Epidemiological Features (2003)

Surveillance after introduction of Haemophilus influenzae serotype b vaccination in Spain identified 26 H. influenzae serotype e (HiE) isolates. Of these, 16 (61.5%) were recovered from patients aged >16 years and 10 (38.5%) from children <16 years of age. HiE caused respiratory infections in 14 patients (9 with pneumonia), conjunctivitis in 4, vaginitis in 2, abscess in 2, and cellulitis, peritoneal infection, sepsis and meningitis in 1 patient each. HiE was strongly clonal and highly resistant to ampicillin and cotrimoxazole, and the incidence of HiE infection did not increase over time.
Young Offenders: II. Custodial Sentences for Young Adult Offenders: A Critique (1981)

Abstract The White Paper Young Offenders deliberately avoids any attempt at establishing a definite philosophical framework within which to develop a rationally based system of custodial measures. Whilst it can be regarded as moving towards a “justice” model in proposing the abolition of borstal training, when taken together with its other provisions there are strong indications of a deeply rooted ambivalence. To advocate greater use of non‐custodial measures whilst at the same time proposing measures apparently designed to ensure an increase in the use of custodial sentences borders on the schizophrenic. In short, whilst some of the proposals are to be welcomed, the total package is likely to prove retrogressive.
Advances in the CIS research at NREL (2002)

This paper summarizes the research of the CIS Team at NREL in three major areas: absorber deposition; understanding the role of chemical bath deposited (CBD) CdS in CIS junctions; and in the development of devices without CdS. Low cost, scaleable processes chosen for absorber fabrication include sputtering, electrodeposition (ED), and close spaced sublimation (CSS). The interaction between the CBD and the CIS has been investigated and the results show that Cd might be instrumental in shaping the interface. We have also developed a process to fabricate a 13.5% efficiency ZnO/CulnGaSe/sub 2/ device without CdS or other buffer layers.
Functional Fixedness in a Technologically Sparse Culture (2005)

Problem solving can be inefficient when the solution requires subjects to generate an atypical function for an object and the object's typical function has been primed. Subjects become "fixed" on the design function of the object, and problem solving suffers relative to control conditions in which the object's function is not demonstrated. In the current study, such functional fixedness was demonstrated in a sample of adolescents (mean age of 16 years) among the Shuar of Ecuadorian Amazonia, whose technologically sparse culture provides limited access to large numbers of artifacts with highly specialized functions. This result suggests that design function may universally be the core property of artifact concepts in human semantic memory.
(Invited) Band-Edge Effective Work Functions by Controlling HfO<sub>2</sub>/TiN Interfacial Composition for Gate-Last CMOS (2011)

Effective work function (EWF) changes of TiN/HfO 2 annealed at low temperatures in different ambient environments are correlated to the atomic concentration of oxygen, nitrogen, and aluminum at the metal/dielectric interface. Low EWFs (4.0 eV) are obtained by allowing aluminum to migrate to the TiN/HfO 2 interface during a forming gas anneal. High EWFs (5.1 eV) are achieved with anneals that incorporate oxygen throughout the TiN with [O] = 2.8x10 21 cm -3 near the TiN/HfO 2 interface. First-principles calculations indicate the exchange of O and N atoms near the TiN/HfO 2 interface cause the formation of dipoles that increase the EWF.