gebhart/patrepeval huggingface dataset:
The effect of human nature logo nursing in neurosurgery department (2011)

Objective To discuss the effect of human nature logo nursing in neurosurgery department. Methods There were 120 head injury inpatients from March to December in 2009, which were divided into observation and control groups, each had 60 cases, all the patients were given routine drug treatment. The control group were accepted routine nursing, and the observation group was accepted human nature logo nursing. The inpatients'degree of satisfaction questionnaire, SCL- 90, neurologic impairment assessment questionnaire were used to evaluate the clinical effect at leaving hospital. Results At leaving hospital, the sense of security, satisfaction, respection were 88. 3%,96. 7%, 95. 0% respectively in observation group, and they were 63. 3%, 66. 7%,68. 3% respectively in control group; the score of SCL-90 in observation group was 136.38 ±16.29, and it was 149.67 ±13.71 in control group; the score of neurologic impairment assessment in observation group was 12.04 ±4.61, and it was 16. 11 ±5.48 in control group; the sense of synthesis satisfaction in observation group was 99. 3%, and it was 81. 7% in control group, and there were significant difference between the two groups ( all P ＜ 0. 01 ).Conclusions Human nature logo nursing on the head injury inpatients can enhance the sense of satisfaction and improve the psychological state, promote their nervus function rehabilitation.

Key words: 
Neurosurgery department;  Head injury;  Human nature logo;  Sense of satisfaction;  Nerve function
The Impact of Physician Screening on Melanoma Detection (2011)

Physician-based screening leads to higher rates of physician-detected melanoma and detection of thinner melanoma.
Identification and quantitation of sickle cell hemoglobin with an enzyme-linked immunosorbent assay (ELISA). (1980)

The experimental details of ELISA for the identification and quantitation of Hb S are presented; the assay is based upon the passive adsorption of Hb S top a solid phase (polystyrene tubes) and the addition of monospecific rabbit antibodies capable of recognizing the (beta 6 Glu leads to Val) substitution in Hb S. After the addition of alkaline phosphatase-conjugated goat antibody to rabbit IgG and substrate, the yellow color produced by hydrolysis of substrate is measured spectrophotometrically. For the identification and quantitation of Hb S in unknown samples, the hemolysate is added to the Hb S-coated tubes before the addition of antibody to Hb S, thus causing an inhibition of the antigen-antibody reaction as evidenced by an absence or reduction of color formation. With this procedure, there is no cross-reactivity with normal hemoglobins, and the immunoassay has a sensitivity in detecting 50 ng quantities of the abnormal hemoglobin in a 5 microgram hemolysate. The assay can be performed on multiple samples in 1 day and offers many advantages over other techniques currently used for the identification and quantitation of Hb S and other abnormal hemoglobins in the clinical laboratory.
Reaction Based Fluorescent Probes for Hydrogen Sulfide (2012)

A reaction based fluorescence turn-on strategy for hydrogen sulfide (H(2)S) was developed. This strategy was based on a H(2)S-specific Michael addition-cyclization sequence. Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide.
Analysis of telemetry data from a real-time strategy game (2012)

This article describes the analysis of a simple, free-to-play real-time strategy (RTS) game called Pixel Legions. In developing this analysis, we worked with the developer to instrument, collect, and analyze telemetry data. The game design questions examined constitute macro- and micro-level analysis. We used pre-existing statistical and visualization tools to examine the macro-level questions. However, micro-level analysis was more game-specific, which required us to develop a novel visualization system to answer these questions in a way that is easy for the designer to understand. Our contribution constitutes the system we built and the analysis we developed to answer the questions imposed by the designer.
Effects of Alpha-galactosidase Supplementation to Corn-soybean Meal Diets on Nutrient Utilization, Performance, Serum Indices and Organ Weight in Broilers (2005)

Effects of alpha-galactosidase (GAL) on broiler corn-soybean meal diet was investigated. In experiment 1, sixty cockerels were allocated to five groups, including three enzyme treatments (GAL added at 0, 500, and 1,000 mg/kg diet), a nitrogen-free diet group and a fast group. The true nitrogen-corrected ME (TME n ) and true amino acid availability were determined. In experiment 2, 324 day-old chicks were used in a 23 factorial design consisting of two energy contents (high and low) and three GAL levels (0, 250, and 500 mg/kg). Three feeding phases, comprising 0-21 d, 22-35 d and 36-48 d, were involved. GAL addition improved TME n and the availability of methionine and cystine (p<0.05). The apparent ME (AME) or nitrogen-corrected AME (AME n ) and digestibility of dry matter, organic matter, calcium, and phosphorus were improved significantly on d 21, so was crude protein and an interaction of energy and GAL on AME n (p<0.05) was found on d 35. However, daily intake and daily gain were significantly improved with GAL addition (p<0.05) during 21 d. The small intestine relative weight decreased at 250 mg/kg GAL (p<0.05) on d 35, whereas presented an interaction between GAL and energy on d 21 (p<0.05). Likewise, this treatment increased breast muscle ratio (p<0.05). On d 21, triglycerides level of broilers showed interaction between energy and enzyme levels (p<0.05). Uric acid level in 500 mg/kg GAL declined linearly (p<0.05). On d 35, quadratic effects (p<0.05) were observed in total protein, albumin, globulin and cholesterol content for enzyme supplementation. And the interactive effects of energy and GAL on serum values showed more obviously. The study implies that GAL improved energy and nutrient availability of corn-soybean meal diet in broiler. The GAL supplementation to corn-soybean meal based diet can improve performance of broilers in early stages of growth. (
A Portrait of a Reading Teacher (1995)

Teacher knowledge is dynamic and experiential. It is both constructed and reconstructed daily as teachers live out their lives in and out of school (Clandinin and Connelly, 1991). Therefore, listening to teachers' stories can be a valuable avenue to gaining insights into the methods other teachers use to teach children to read. My goal is to share one teacher's story in such a way that readers will reflect on their own stories and examine their practices of reading instruction, their knowledge and beliefs, and how all these elements of teaching are interrelated. It is up to readers to take from this qualitative research those parts which fit their individual professional development needs.
Properties of crimpable archwire hooks: a laboratory investigation (1999)

The aim of the present study was to utilize a strain gauge, which enabled the force applied to produce firmly attached crimpable hooks to rectangular stainless steel arch wires, to be measured. In vitro testing of two hooks, American Orthodontic (AO) and TP Orthodontic (TP), and two dimensions of stainless steel archwire, 0.019 x 0.025 and 0.018 x 0.025-inch, was carried out using an Instron Universal Testing machine. The results demonstrate that there was a significant difference in the behaviour of the two types of crimpable hooks, with almost twice the force needed to dislodge the TP hooks compared with the AO hooks (11.7 and 6.22 N, respectively). When using TP hooks attached to either 0.019 x 0.025 or 0.018 x 0.025-inch stainless steel wires, the archwire size makes little difference to the force required to produce movement. The clinical significance of these findings is discussed.
Biophysics of DNA (2015)

Surveying the last sixty years of research, this book describes the physical properties of DNA in the context of its biological functioning. It is designed to enable both students and researchers of molecular biology, biochemistry and physics to better understand the biophysics of DNA, addressing key questions and facilitating further research. The chapters integrate theoretical and experimental approaches, emphasising throughout the importance of a quantitative knowledge of physical properties in building and analysing models of DNA functioning. For example, the book shows how the relationship between DNA mechanical properties and the sequence specificity of DNA-protein binding can be analyzed quantitatively by using our current knowledge of the physical and structural properties of DNA. Theoretical models and experimental methods in the field are critically considered to enable the reader to engage effectively with the current scientific literature on the physical properties of DNA.
A Novel Mutation in Helix 12 of the Vitamin D Receptor Impairs Coactivator Interaction and Causes Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets without Alopecia (2002)

Hereditary vitamin D-resistant rickets (HVDRR) is a genetic disorder most often caused by mutations in the vitamin D receptor (VDR). The patient in this study exhibited the typical clinical features of HVDRR with early onset rickets, hypocalcemia, secondary hyperparathyroidism, and elevated serum concentrations of alkaline phosphatase and 1,25-dihydroxyvitamin D [1,25-(OH)(2)D(3)]. The patient did not have alopecia. Assays of the VDR showed a normal high affinity low capacity binding site for [(3)H]1,25-(OH)(2)D(3) in extracts from the patient's fibroblasts. However, the cells were resistant to 1,25-dihydroxyvitamin D action as demonstrated by the failure of the patient's cultured fibroblasts to induce the 24-hydroxylase gene when treated with either high doses of 1,25-(OH)(2)D(3) or vitamin D analogs. A novel point mutation was identified in helix H12 in the ligand-binding domain of the VDR that changed a highly conserved glutamic acid at amino acid 420 to lysine (E420K). The patient was homozygous for the mutation. The E420K mutant receptor recreated by site-directed mutagenesis exhibited many normal properties including ligand binding, heterodimerization with the retinoid X receptor, and binding to vitamin D response elements. However, the mutant VDR was unable to elicit 1,25-(OH)(2)D(3)-dependent transactivation. Subsequent studies demonstrated that the mutant VDR had a marked impairment in binding steroid receptor coactivator 1 (SRC-1) and DRIP205, a subunit of the vitamin D receptor-interacting protein (DRIP) coactivator complex. Taken together, our data indicate that the mutation in helix H12 alters the coactivator binding site preventing coactivator binding and transactivation. In conclusion, we have identified the first case of a naturally occurring mutation in the VDR (E420K) that disrupts coactivator binding to the VDR and causes HVDRR.
Order-Revealing Encryption: New Constructions, Applications, and Lower Bounds. (2016)

In the last few years, there has been significant interest in developing methods to search over encrypted data. In the case of range queries, a simple solution is to encrypt the contents of the database using an order-preserving encryption (OPE) scheme (i.e., an encryption scheme that supports comparisons over encrypted values). However, Naveed et al. (CCS 2015) recently showed that OPE-encrypted databases are extremely vulnerable to attacks. In this work, we consider a related primitive called order-revealing encryption (ORE), which is a generalization of OPE that allows for stronger security. We begin by constructing a new ORE scheme for small message spaces which achieves the notion of security for ORE. Next, we introduce a domain extension technique and apply it to our small-message-space ORE. While our domain-extension technique does incur a loss in security, the resulting ORE scheme we obtain is more secure than all existing (stateless and non-interactive) OPE and ORE schemes which are practical. All of our constructions rely only on symmetric primitives. As part of our analysis, we also give a tight lower bound for OPE and show that no efficient OPE scheme can satisfy best-possible security if the message space contains just three messages. Thus, achieving strong notions of security for even small message spaces requires moving beyond OPE. Finally, we examine the properties of our new ORE scheme and show how to use it to construct an efficient range query protocol that is robust against the inference attacks of Naveed et al. We also give a full implementation of our new ORE scheme, and show that not only is our scheme more secure than existing OPE schemes, it is also faster: encrypting a 32-bit integer requires just 55 microseconds, which is more than 65 times faster than existing OPE schemes.
Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. (2003)

The function of the predisposition gene to multiple endocrine neoplasia type 1 (MEN1) syndrome remains largely unknown. Previous studies demonstrated that null mutation of the Men1 gene caused mid-gestation lethality in mice, whereas heterozygous Men1 knockout mice developed multiple endocrine tumors late in life. To seek direct evidence on the causal role of menin in suppressing tumor development, we generated mice in which the Men1 gene was disrupted specifically in pancreatic beta cells. These mice began to develop hyperplastic islets at as early as 2 months of age and insulinomas at 6 months of age. The islet lesions exhibited features of multistage tumor progression, including beta-cell dedifferentiation, angiogenesis, and altered expression of both E-cadherin and beta-catenin. Additionally, disturbance of blood insulin and glucose levels correlated with tumor development, mimicking human MEN1 symptoms. Our data indicate that this strain of mice provides a powerful tool for the study of the mechanisms of tumorigenesis related to MEN1 disease.
Protein sorting to the vacuolar membrane. (1992)

The vacuolar membrane (tonoplast) of plant cells contains a polytopic integral membrane protein with six membrane-spanning domains and cytoplasmically oriented amino-terminal and carboxy-terminal domains. This protein, tonoplast intrinsic protein (TIP), is a member of the membrane intrinsic protein (MIP) family of proteins, a family of channel proteins found in a variety of organisms. In bean seeds, alpha-TIP is synthesized on the rough endoplasmic reticulum and its transport to the tonoplast is mediated by the secretory system. In this study, we report that a polypeptide segment that includes the sixth membrane domain and the cytoplasmic tail of 18 amino acids of alpha-TIP is sufficient to target the reporter protein phosphinotricine acetyltransferase to the tonoplast of stably transformed tobacco cells. To determine if the carboxy-terminal cytoplasmic tail of alpha-TIP contains important tonoplast targeting information, a deletion construct lacking the 15 carboxy-terminal amino acids was introduced for transient expression in tobacco cells; we found that the slightly truncated protein still accumulated in the tonoplast. From these results, we concluded that a transmembrane domain of a tonoplast protein probably contains sufficient information for transport to the tonoplast. Whether such transport occurs by bulk flow or involves specific cellular machinery remains to be determined.
Computer-based multimedia video conferencing system (1993)

An affordable system level design of a practically prototyped computer-based desktop video conferencing (DVC) system that is capable of delivering full motion analog audio and video is presented. The DVC system is designed to exchange full motion analog video and audio among conference participants using point-to-point and multipoint communication. It is capable of interfacing directly with a codec for video conferencing in the digital domain. The main advantages of this system are low cost, flexibility, and the ability to share applications in an effective manner. The proposed DVC system has been implemented to support 12 users and one additional video/audio input for viewing external television broadcasts.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Advances in DNA-Ligands with Groove Binding, Intercalating and/or Alkylating Activity: Chemistry, DNA-Binding and Biology (2005)

It is known that DNA is a well-characterized intracellular target but its size and sequential characteristics make it an elusive target for selective drug action. Binding of low molecular weight ligands to DNA causes a variety of significant biological responses. In this context the main consideration is given to recent developments in DNA sequence selective binding agents bearing conjugated effectors because of their potential application in treatment of cancers, in diagnosis as well as in molecular biology. In the present review recent results about analogues of netropsins, distamycin A and of some lexitropsins and combilexins or related hybrid molecules with sequence reading, intercalating or alkylating activity are described and evaluated for prospective applications. Furthermore there exists DNA minor groove binder with different basic structures which does not possess the typical polyamide chain, including dimeric intercalating chromophores. Finally new results about peptide nucleic acids and related nucleic acid bases linked with polyamides are reported. In pronounced examples the structural chemistry, synthesis, DNA binding with several biophysical methods, molecular aspects, structure activity relationship, topoisomerase inhibition, antitumour and antibacterial effects are discussed in detail.
Ophthalmic follow‐up of patients with tyrosinaemia type I on NTBC (2003)

NTBC has revolutionized the management of tyrosinaemia type I, although animal experiments have shown that long-term administration may produce corneal opacities analogous to those in tyrosinaemia type II. We have assessed the prevalence of ocular side-effects in 11 tyrosinaemia type I patients on NTBC attending the Birmingham Children's Hospital. Despite high plasma tyrosine concentrations in some patients, they did not experience symptoms or signs of ocular toxicity.
Two-tone CW complex holographic radar imaging (2002)

A method that resolves range using the phase differences between reconstructed two-tone holograms is presented. This method gives very high range resolution in a very narrow frequency band. Experiments showed that the technique can produce recognizable 3-D images of objects at comparatively short distances in free space.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Multipaths and Rate Stability (2016)

Multipath solutions have been shown to help improve throughput, reliability and/or load balancing. This paper seeks to understand if and when they benefit rate stability. Rate stability is important to many real-time, interactive applications, e.g., streaming video, but whether multipath solutions can help is unclear. Of relevance is the time-scale at which bandwidth changes are detected and acted upon to rebalance transmissions across paths. Consider two boundary cases: instantaneous detection and rate re-allocation, and a static rate assignment based on long-term path statistics. When transmissions can be instantaneously rebalanced across paths based on real-time link rate information, a multipath solution trivially improves rate stability (it all but eliminates rate variations). In contrast, when rate allocations are static, we find that multipath cannot improve upon the best single-path solution when buffers are large. When buffers are small (and coding is used to overcome losses), a multipath solution can, however, be beneficial even under a static rate allocation. The paper provides insight into when and how multipath solutions can help improve rate stability.
The VE‐cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial migration of malignant breast epithelial cells (2009)

Fibrin deposition and exudation of plasma fibrinogen (Fg) have long been recognized as hallmarks of inflammation, cardiovascular disease and neoplasia. The Fg-beta(15-42) domain binds to the endothelial cell adhesion molecule, VE-cadherin, promoting endothelial cell proliferation, angiogenesis and leukocyte diapedesis. Furthermore, spontaneous blood-borne and lymphatic metastasis of some types of tumor emboli requires plasma fibrin(ogen); however, the molecular mechanisms by which this occurs are poorly understood. We sought to determine whether Fg-beta(15-42) and VE-cadherin binding interactions promote endothelial barrier permeability and breast cancer cell transendothelial migration (TEM) using transwell insert culture systems. Synthetic peptides containing/missing residues beta(15-17) critical for Fg-beta(15-42) binding to VE-cadherin, and antibodies that bind to Fg-beta(15-21) (T2G1) and VE-cadherin (BV9) were used to induce or inhibit Fg-mediated permeability and TEM. Fg induced dose-dependent permeability of human umbilical vein and microvascular endothelial but not epithelial cell barriers. Maximal Fg-induced endothelial permeability required Fg-beta(15-42) and VE-cadherin-binding interactions involving Fg-beta(15-17). Fg-induced TEM of malignant MDA-MB-231 and MCF-7 breast cancer cells also required Fg-beta(15-42) and VE-cadherin binding; however, such TEM was independent of E-cadherin or estrogen receptor expression. In contrast, Fg did not induce TEM of nonmalignant MCF-10A breast epithelial cells. Fg-induced endothelial permeability was retained in the presence of MDA-MB-231 but inhibited in the presence of MCF-10A cells. It is intriguing to speculate that loss of Fg-beta(15-42) binding by premalignant breast epithelial cells serves as a molecular switch to induce a highly aggressive, metastatic breast cancer phenotype. Hence, Fg-beta(15-42) represents a potential molecular target for therapeutic intervention of breast cancer metastasis.
A suction blister method that gives epidermal biopsies from mice of different ages, suitable for histologic studies of Langerhans cells. (1987)

A modified suction blister device has been developed. It allows in vivo retrieval of 3 x 3 mm2 mouse epidermis biopsies. Separation takes place exactly at the epidermal-dermal junction. Young skin and iso-grafted skin require suction with a lower bar value than skin from young and old non-grafted animals. Langerhans cells in biopsies were identified both with ATPase staining and with monoclonal antibody. Suction blisters produce Langerhans cell counts similar to those obtained on EDTA-separated epidermis.
The world economy [March 1993] (1993)

In the third quarter of 1992 quarterly GDP/GNP growth averaged -0.1% in the main four world economies. The position of the USA improved but growth slowed dramatically in Japan and Germany. This analysis sets out growth rates for each country and provides a provisional estimate for the USA and the UK in the fourth quarter. Growth rates for these two are the normally quoted annualized quarterly growth rates.