gebhart/patrepeval huggingface dataset:
Ordered End-Member of ZSM-48 Zeolite Family (2008)

ZSM-48 and related zeolites are considered to be highly disordered structures. Different polytypes can be clearly distinguished by simulation of high-resolution electron microscopy images. Synthesis of phase-pure polytypes was attempted. One of the investigated samples crystallized via seeding designated as COK-8 consisted of nanoscopic, needlelike crystals with a very large length/width ratio, growing along the pore direction. These specimens are phase-pure polytype 6 (PT6, numbering according to Lobo and van Koningsveld). Aggregates of these nanoneedles occasionally contained a second polytype: PT1. The latter polytype occurred more abundantly in larger crystal rods in an IZM-1 sample crystallized in ethylene glycol. Here too, the isolated crystallites mainly consist of large, defect-free regions of PT6. A simulation of polytype lattice energies offers a rational explanation for the observed polytypical intergrowth formation.
Genetic Characterization of H1N2 Influenza A Viruses Isolated from Pigs throughout the United States (2002)

An H1N2 influenza A virus was isolated from a pig in the United States for the first time in 1999 (A. I. Karasin, G. A. Anderson, and C. W. Olsen, J. Clin. Microbiol. 38:2453-2456, 2000). H1N2 viruses have been isolated subsequently from pigs in many states. Phylogenetic analyses of eight such viruses isolated from pigs in Indiana, Illinois, Minnesota, Ohio, Iowa, and North Carolina during 2000 to 2001 showed that these viruses are all of the same reassortant genotype as that of the initial H1N2 isolate from 1999.
Gene Silencing of HIV-1 by RNA Interference (2004)

Short interfering RNAs (siRNAs) are as effective at targeting and silencing genes by RNA interference (RNAi) as long double-stranded RNAs (dsRNAs). siRNAs are widely used for assessing gene function in cultured mammalian cells or early developing vertebrate embryos. siRNAs are also promising reagents for developing gene-specific therapeutics. Specifically, the inhibition of HIV-1 replication is particularly well-suited to RNAi, as several stages of the viral life cycle and many viral and cellular genes can be targeted. The future success of this approach will depend on recent advances in siRNA-based silencing technologies.
Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-<i>tert</i>-Butyl-2-<i>p</i>-tolyl-2<i>H</i>-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796) (2003)

We report on the structure-activity relationships (SAR) of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea (BIRB 796), an inhibitor of p38alpha MAP kinase which has advanced into human clinical trials for the treatment of autoimmune diseases. Thermal denaturation was used to establish molecular binding affinities for this class of p38alpha inhibitors. The tert-butyl group remains a critical binding element by occupying a lipophilic domain in the kinase which is exposed upon rearrangement of the activation loop. An aromatic ring attached to N-2 of the pyrazole nucleus provides important pi-CH(2) interactions with the kinase. The role of groups attached through an ethoxy group to the 4-position of the naphthalene and directed into the ATP-binding domain is elucidated. Pharmacophores with good hydrogen bonding potential, such as morpholine, pyridine, and imidazole, shift the melting temperature of p38alpha by 16-17 degrees C translating into K(d) values of 50-100 pM. Finally, we describe several compounds that potently inhibit TNF-alpha production when dosed orally in mice.
Quantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoring (2012)

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1649068103671302.
Minimal Loss Hashing for Compact Binary Codes (2011)

We propose a method for learning similaritypreserving hash functions that map highdimensional data onto binary codes. The formulation is based on structured prediction with latent variables and a hinge-like loss function. It is efficient to train for large datasets, scales well to large code lengths, and outperforms state-of-the-art methods. 1.
The Magnitude of Acute Serum Creatinine Increase After Cardiac Surgery and the Risk of Chronic Kidney Disease, Progression of Kidney Disease, and Death (2011)

The magnitude of creatinine increase after cardiac surgery is associated in a graded manner with an increased risk of incident CKD, CKD progression, and mortality.
Federated Dynamic Security and Process Management Within Service Grids (2004)

Abstract: The latest trend in distributed systems architecture is the development of Service-Oriented Architecture (SOA) where new and existing software assets are broken down into services that are available to multiple applications and processes. The vision is that this new architectural paradigm will lead to a world where organizations will share services composed dynamically from components across many distributed systems and spanning different organizations. But before this vision can become reality, software architects and businesses must find a way to provide consistent real-time and context aware security across distributed processes while meeting the diverse needs of different shareholder organizations, each with its own security mechanisms and policies. This paper proposes a service grid construct supporting federated and dynamic security within the service grids, explaining how the federated security concept meets the needs of diverse systems and organizations and exploring the business and technology implications of the federated security grid concept.
Cooperative co-learning: a model-based approach for solving multi-agent reinforcement problems (2003)

Solving multiagent reinforcement learning problems is a key issue. Indeed, the complexity of deriving multiagent plans, especially when one uses an explicit model of the problem, is dramatically increasing with the number of agents. This papers introduces a general iterative heuristic: at each step one chooses a sub-group of agents and update their policies to optimize the task given the rest of agents have fixed plans. We analyse this process in a general purpose and show how it can be applied to Markov decision processes, partially observable Markov decision processes and decentralized partially observable Markov decision processes.
Left-Handed Transmission Characteristics of Ferrite Microstrip Lines without Series Capacitive Loading (2006)

A nonreciprocal left-handed transmission line is proposed and investigated, which is composed of a normally magnetized ferrite microstrip line periodically loaded with inductive stubs but without capacitive loading. The circuit configuration becomes simpler than that of a nonreciprocal left-handed transmission line with both shunt inductive and series capacitive loadings. In the proposed structure, ferrite medium is employed as the substrate not only for the nonreciprocal characteristics but also for negative effective permeability that is essential to establish the left-handedness. After calculations of dispersion curves using equivalent circuit model, scattering parameters along with field patterns are estimated numerically with the help of electromagnetic simulation, and the experiments are also carried out. It is found that the band width of the proposed left-handed transmission line is relatively narrow but the structure still has the high isolation ratio of more than 30 dB.
On the importance of parallel application placement in NUMA multiprocessors (1993)

The thesis of this paper is that scheduling decisions in large-scale, sharedmemory, NUMA (Non-Uniform Memory Access) multiprocessors must consider not only how many processors, but also which processors to allocate to each application. We call the problem of assigning parallel processes of an application to processors application placement. We explore the importance of placement decisions by measuring the execution time of several parallel applications using different placements on a sharedmemory NUMA multiprocessor. The results of these experiments lead us to conclude that, as expected, in small-scale mildly NUMA multiprocessors, placement decisions have only a minor affect on the execution time of parallel applications. However, the results also show that placement decisions in largescale multiprocessors are critical and localization that considers the architectural clusters inherent in these systems is essential. Our experiments also show that the importance of placement decisions increases substantially with the size and NUMAness of the system and that the placement of individual processes of an application within the subset of chosen processors also significantly impacts performance.
Laser streaming: Turning a laser beam into a flow of liquid (2017)

Transforming a laser beam into a mass flow has been a challenge both scientifically and technologically. We report the discovery of a new optofluidic principle and demonstrate the generation of a steady-state water flow by a pulsed laser beam through a glass window. To generate a flow or stream in the same path as the refracted laser beam in pure water from an arbitrary spot on the window, we first fill a glass cuvette with an aqueous solution of Au nanoparticles. A flow will emerge from the focused laser spot on the window after the laser is turned on for a few to tens of minutes; the flow remains after the colloidal solution is completely replaced by pure water. Microscopically, this transformation is made possible by an underlying plasmonic nanoparticle-decorated cavity, which is self-fabricated on the glass by nanoparticle-assisted laser etching and exhibits size and shape uniquely tailored to the incident beam profile. Hydrophone signals indicate that the flow is driven via acoustic streaming by a long-lasting ultrasound wave that is resonantly generated by the laser and the cavity through the photoacoustic effect. The principle of this light-driven flow via ultrasound, that is, photoacoustic streaming by coupling photoacoustics to acoustic streaming, is general and can be applied to any liquid, opening up new research and applications in optofluidics as well as traditional photoacoustics and acoustic streaming.
Human Umbilical Cord-Derived Mesenchymal Stromal Cells Differentiate Into Functional Schwann Cells That Sustain Peripheral Nerve Regeneration (2010)

Human umbilical cord-derived mesenchymal stromal cells (UC-MSCs) that are available from cell banks can be induced to differentiate into various cell types, thereby making them practical potential sources for cell-based therapies. In injured peripheral nerves, Schwann cells (SCs) contribute to functional recovery by supporting axonal regeneration and myelin reconstruction. Here, we first demonstrate a system to induce UC-MSCs to differentiate into cells with SC properties (UC-SCs) by treatment with β-mercaptoethanol followed by retinoic acid and a set of specific cytokines. The UC-SCs are morphologically similar to SCs and express SC markers, including P0, as assessed by immunocytochemistry and reverse transcription polymerase chain reaction. Transplantation of UC-SCs into transected sciatic nerves in adult rats enhanced nerve regeneration. The effectiveness of UC-SCs for axonal regeneration was comparable to that of authentic human SCs based on histological criteria and functional recovery. Immunohistochemistry and immunoelectron microscopy also demonstrated myelination of regenerated axons by UC-SCs. These findings indicate that cells with SC properties and with the ability to support axonal regeneration and reconstruct myelin can be successfully induced from UC-MSCs to promote functional recovery after peripheral nerve injury. This system may be applicable for the development of cell-based therapies.
Two experiences designing for effective security (2005)

In our research, we have been concerned with the question of how to make relevant features of security situations visible to users in order to allow them to make informed decisions regarding potential privacy and security problems, as well as regarding potential implications of their actions. To this end, we have designed technical infrastructures that make visible the configurations, activities, and implications of available security mechanisms. This thus allows users to make informed choices and take coordinated and appropriate actions when necessary. This work differs from the more traditional security usability work in that our focus is not only on the usability of security mechanism (e.g., the ease-of-use of an access control interface), but how security can manifest itself as part of people's interactions with and through information systems (i.e., how people experience and interpret privacy and security situations, and are enabled or constrained by existing technological mechanisms to act appropriately). In this paper, we report our experiences designing, developing, and testing two technical infrastructures for supporting this approach for usable security.
Synthesis of Organothiophosphate Antigens for the Development of Specific Immunoassays (1993)

By use of t-butyl 3-[ chloro ( methoxy ) phosphorothioylamino ] propanoate (1), a general method was developed that allowed the preparation of analogues of specific organothiophosphates ; these analogues are suitable for use as haptens in the development of tests for detection of the individual organophosphates. The bifunctional reagent (1) was conveniently prepared from readily available starting materials.
Homogeneous layer models for high-spatial-frequency dielectric surface-relief gratings: conical diffraction and antireflection designs (1994)

The validity of various homogeneous layer models for high-spatial-frequency rectangular-groove (binary) dielectric surface-relief gratings is examined for both nonconical and conical diffraction. In each model the grating is described by a slab of uniaxial material with its optic axis parallel to the grating vector. The ordinary and principal extraordinary indices of the slab depend on the grating filling factor, the substrate and cover refractive indices, and the ratio of the wavelength to the grating period. These indices can be determined by solving two transcendental equations. Higher-order indices are defined as the exact solution to these equations. Second-order indices (second-order dependence on the wavelengthto- period ratio) and first-order indices (no dependence on the wavelength-to-period ratio) are defined by approximate solutions to these equations. Layer models using higher-order and second-order indices are shown to be accurate for high-spatial-frequency gratings, even at wavelength-to-period ratios near the onset of higher-order propagating diffracted waves. These models are used to design example antireflecting gratings on silicon substrates, including designs for conical incidence. All designs are evaluated and optimized by exact rigorous coupled-wave analysis.
Performance of a 41×41‐cm amorphous silicon flat panel x‐ray detector for radiographic imaging applications (2000)

We report the performance of a 41 X 41-cm2 amorphous silicon-based flat panel detector designed for radiographic imaging applications. The detector consists of an array of photodiodes and thin film transistor switches on a 0.2-mm pitch with an overlying thallium-doped cesium iodide scintillator. The performance of the detector was evaluated through measurement of the frequency-dependent detective quantum efficiency [DQE(f)]. Measurements of the characteristic curve and modulation transfer function (MTF) are also reported. All measurements were made in a radiographic imaging mode with a readout time of 125 ms. We evaluated a total of 15 detectors. One detector was characterized at a range of exposures and at three different electronic gain settings. Measurements of DQE(f) and MTF were also performed as a function of position on one detector. The measured DQE at an exposure of about 1 mR was 0.66 at zero spatial frequency and fell smoothly with frequency to a value of 0.24 at the Nyquist frequency, 2.5 cycles/mm. The DQE is independent of exposure for exposures in the upper 80% of each gain range, but is reduced somewhat at lower exposures because of the influence of additive system noise. The reduction can be controlled by adjusting the electronic gain. For a gain that allows a maximum exposure of 5 mR, the DQE at 0.056 mR was 0.64 at zero frequency and 0.19 at 2.5 cycles/mm. The standard deviation in DQE among measurements on different detectors was less than 0.02 at any frequency. The presampling MTF was 0.26 at 2.5 cycles/mm. The standard deviation in MTF among measurements on different detectors was less than 0.01 at any frequency. Both MTF and DQE were substantially independent of position on the detector.
<i>In vivo</i> fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis (2005)

Amyloid diseases encompass >20 medical disorders that include amyloid protein A (AA) amyloidosis, Alzheimer's disease, and type 2 diabetes. A common feature of these conditions is the selective organ deposition of disease-specific fibrillar proteins, along with the sulfated glycosaminoglycan, heparan sulfate. We have generated transgenic mice that overexpress human heparanase and have tested their susceptibility to amyloid induction. Drastic shortening of heparan sulfate chains was observed in heparanase-overproducing organs, such as liver and kidney. These sites selectively escaped amyloid deposition on experimental induction of inflammation-associated AA amyloidosis, as verified by lack of material staining with Congo Red, as well as lack of associated polysaccharide, whereas the same tissues from control animals were heavily infiltrated with amyloid. By contrast, the spleens of transgenic mice that failed to significantly overexpress heparanase contained heparan sulfate chains similar in size to those of control spleen and remained susceptible to amyloid deposition. Our findings provide direct in vivo evidence that heparan sulfate is essential for the development of amyloid disease.
Electronic Design Automation (EDA) Scheduling System in IC Design Industry (2019)

With the global competition and short life cycle in semiconductor industry, the IC design companies try to keep their competitiveness. Besides the human resources and advanced technology, enhancing the speed of the development is an important method to enhance market share. IC designers usually use electronic design automation tool to shorten the development. However, the EDA tools and resources are expensive and limited. Hence, it becomes a critical problem to allocate the resources and schedule the jobs. This study aimed to develop an IC design job scheduling decision support system framework. The framework enhances the throughput and reduces the idle. This study implements the proposed framework in practice. The empirical study conducted in IC design company to validate the developed solution and model implementation.
Thermodynamic model for solvating solutions with physical interactions (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamic model for solvating solutions with physical interactionsEugene E. Spala and Neil L. RickerCite this: Ind. Eng. Chem. Process Des. Dev. 1982, 21, 3, 409–415Publication Date (Print):July 1, 1982Publication History Published online1 May 2002Published inissue 1 July 1982https://doi.org/10.1021/i200018a011Request reuse permissionsArticle Views95Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (866 KB) Get e-Alerts
Treating cardiovascular disease in women (2007)

Cardiovascular disease (CVD) is the most common cause of death in women but some of the challenges of management differ from those in men. This article addresses the gender-specific issues of cardiovascular management, with emphasis on ischaemic heart disease and modification of coronary risk factors. Women with ischaemic heart disease present later than men, and are therefore older and more likely to suffer from co-morbidities such as diabetes and hypertension. Proven CVD risk factors in women can be divided into those that are modifiable and those that are non-modifiable. The former include diabetes, dyslipidaemia, hypertension, smoking, obesity, sedentary lifestyle and poor nutrition; the latter include family history of heart disease and older age at presentation. It is this difference in age and general health that explains much of the variability in response to treatment. Pharmacotherapy, percutaneous intervention, surgical revascularization, and cardiac rehabilitation and disease prevention are discussed.
A new load shedding scheme for limiting underfrequency (1994)

In large interconnected power systems, serious frequency falls now require a very heavy loss of generation and should such an event occur, the rate of frequency decline would be greater than had been considered at the time when underfrequency load shedding (ULFS) had been developed. Obviously the character of the power systems have changed and yet no corresponding modification of ULFS has been made and there is still shedding of pre-selected loads throughout the entire power system. This paper proposes a new scheme utilising frequency and voltage changes to shed loads specifically in the most affected localities while regaining the load-generation balance for each incident. Simulation studies on an extensive interconnected network, following very severe loss of generation, show the advantages of the proposed scheme to the actions of existing ULFS.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Direct Observation of the Mechanical Properties of Single-Walled Carbon Nanotubes and Their Junctions at the Atomic Level (2003)

Starting from an amorphous C film, single-walled carbon nanotubes were obtained in situ in a high-resolution electron microscope by the combined effect of irradiation and axial strain. Ductile nanotubes developed either a junction or a linear chain of C atoms before failure. These facts have been put in direct evidence for the first time. Tight-binding calculations indicate that the bonding in the linear chain is of a cumulene type.
Improving Diabetes Management With a Patient Portal: A Qualitative Study of Diabetes Self-Management Portal (2012)

This qualitative study shows that online chronic disease management portals increase patient access to information and engagement in their health care, but improvements in the portal itself may improve usability and reduce attrition. Furthermore, this study identifies a grey area that exists in the roles that GPs and AHPs should play in the facilitation of online disease management.