gebhart/patrepeval huggingface dataset:
A control authority transition system for collision avoidance (2002)

Drivers differ significantly in their skill levels, driving habits, capabilities and decisions especially when impaired by drugs, fatigue or physical handicaps. Late or inadequate responses to hazards and dangers may cause severe results. It may be possible to improve the ability of a driver to operate a vehicle safely if certain parameters in the control of the vehicle axe adjusted according to the driver's normal characteristics. Value has already been established for tailoring certain attributes such as seat, pedals, steering wheel position and mirrors to a given driver through memory functions. This research concentrates on assessing a driver's operating characteristics and modifying the control of the vehicle to improve safe operation of the vehicle on a real-time basis.
Electrical and optical properties of deep ultraviolet transparent conductive Ga<sub>2</sub>O<sub>3</sub>/ITO films by magnetron sputtering (2010)

Ga2O3/ITO films were prepared by magnetron sputtering on quartz glass substrates. The transmittance and sheet resistance of ITO films and Ga2O3/ITO films were measured by using a double beam spectrophotometer and four point probes. The effect of the ITO layer and Ga2O3 layer thickness on the electrical and optical properties of Ga2O3/ITO bi-layer films were investigated in detail. Ga2O3 (50 nm)/ITO (23 nm) films exhibited a low sheet resistance of 323 Ω/□ and high deep ultraviolet transmittance of 77.6% at a wavelength of 280 nm. The ITO layer controls the ultraviolet transmittance and sheet resistance of Ga2O3/ITO films. The Ga2O3 layer thickness has a marked effect on the transmission spectral shape of Ga2O3/ITO films in the violet spectral region.
Decomposing the Promotional Revenue Bump for Loyalty Program Members versus Nonmembers (2005)

Loyalty programs lead to a natural split of a firm's customer base into members and nonmembers. To manage both groups effectively, it is essential to know how marketing activities, such as promotions, affect both groups' contributions to revenues. The authors model each group's contribution as the number of daily buyers times their average expenditures. The model also includes the number of nonbuyers because they may return as customers. Moreover, nonbuyers may influence the expenditures of other customers through crowding effects, and they use personnel time. Model application to two years of daily data from six clothing stores reveals that the number of nonmembers who buy is much more responsive to price discounts than the number of members who buy. Thus, the decomposition of the promotional revenue bump is strongly moderated by the percentage price discount and the communication mode: direct mail to members only and door-to-door flyers to members and nonmembers.
Phytochemical screening, antioxidant, antibacterial and cytotoxic activities of Knema angustifolia extracts. (2010)

Knema angustifolia Warb (Myristicaceae) is used in traditional Thai medicine as a whole body tonic agent. The current study sought to evaluate the antioxidant, antibacterial and cytotoxic activities of extracts from this herb and to screen their chemical constituents. Antioxidant, antibacterial and cytotoxic activities were determined by the DPPH scavenging method, the disk diffusion method and the colorimetric method, respectively. Phytochemical screening was performed using standard procedures. The results showed that the ethanol extract had high antioxidant activity with an EC 50 value of 13.90 ± 1.35 μg/ml. The ethanol and the dichloromethane extracts were active against Staphylococcus aureus. The ethanol extract showed a strong cytotoxic activity against the lung cancer cell line with an IC50 value of 4.55 ± 4.60 μg /ml. Phytochemical screening of the extracts showed the presence of condensed tannins, phenolic compounds and triterpenes. In conclusion, the apparent antioxidant and cytotoxic activities of K. angustifolia suggest its potential usefulness in the prevention of cancer and other diseases.
Seamless TCP mobility using lightweight MPTCP proxy (2013)

We present a TCP mobility solution for the mobile Internet which enables seamless session end-point migration across multi-provider network environments. The solution can be applied by mobile devices to conduct energy-efficient network selection and dynamic spectrum sharing or by data centers to facilitate service migration across IP domains. We leverage MPTCP's in-band signaling protocol to provide the necessary robustness against firewall- and middle-box policies encountered in these environments. The mobility solution builds on a lightweight MPTCP proxy function which is inserted into the data path and performs header rewriting without packet buffering or stream assembly. The proxy is therefore easily integrated into mobile devices, network routers or data center nodes hence facilitating fast deployment. We discuss the use cases, deployment scenarios and algorithmic challenges of the proxy design. We also present a Linux implementation, demonstrate its functionality and prove the proxy's interoperability with native MPTCP transport-layer implementations.
Recent Advances in Olefin Polymerization Using Binary Catalyst Systems (2001)

Several homogeneous and heterogeneous binary systems have been applied to olefin polymerization in order to produce polymers with improved physical and/or chemical characteristics. This article reviews the recent developments in this area focusing mainly on polymer properties, the relationship between the types of catalyst present in the binary systems, their use in the homopolymerization of ethylene and propene, and the copolymerization of ethylene and higher α-olefins.
Presence of chromosomal abnormalities and lack of AIDS retrovirus DNA sequences in AIDS-associated Kaposi's sarcoma. (1986)

The frequent occurrence of Kaposi's sarcoma (KS) in association with the acquired immune deficiency syndrome (AIDS) could be due to the fact that the etiological agent of this tumor is the same retrovirus causing AIDS, to another oncogenic virus frequently found in AIDS patients, or to the unmasking of the tumorigenic potential of KS cells by immunosuppression. We have therefore investigated the presence of DNA sequences homologous to the AIDS retrovirus, cytomegalovirus (CMV), and hepatitis B virus in 13 KS necropsies and biopsies from AIDS patients. All KS DNA samples were negative for AIDS retrovirus or hepatitis B DNA sequences. Two DNAs from necropsies contained CMV DNA, but the data suggested the presence of replicating CMV DNA due to generalized infection. We have also studied cell cultures derived from KS skin biopsies of AIDS patients. These cultures had a short lifetime in vitro and expressed some markers of endothelial cells. The cells were not tumorigenic in nude mice but contained a number of chromosomal rearrangements which were often monoclonal within the same culture. However, these abnormalities were different from culture to culture and even in cultures from the same biopsy. The presence of these chromosomal abnormalities seemed to correlate with the cell positivity for endothelial markers. Taken together these results indicate that neither the AIDS retrovirus, CMV, or hepatitis B virus is directly responsible for the altered growth of KS cells, that KS may be polyclonal even within the same lesion, and that KS cells have a tendency to karyotypic rearrangements.
Physical and biological characterization of a growth-inhibitory activity purified from the neuroepithelioma cell line A673 (1995)

Epithelial- and haematopoietic-cell growth-inhibitory activities have been identified in the conditioned medium of the human peripheral neuroepithelioma cell line A673. An A673-cell-derived growth-inhibitory activity was previously fractionated into two distinct components which inhibited the proliferation of human carcinoma and leukaemia cells in culture. One inhibitory activity was shown to comprise interleukin-1 alpha (IL-1 alpha). Here, we have purified to homogeneity a distinct activity which inhibited the growth of the epithelial cells in vitro. Using a combination of protein-sequence analysis and mass spectrometry, we demonstrated that biological activity can be assigned to a dimeric protein with a molecular mass of 25,576 (+/- 4) Da and an N-terminal sequence identical with that of transforming growth factor-beta 1 (TGF-beta 1). Further characterization of the growth inhibitor with TGF-beta-isoform-specific antibodies showed that &gt; 90% of the bioactivity consists of TGF-beta 1 and not TGF-beta 2 or TGF-beta 3. Although A673 cells were growth-inhibited by exogenous TGF-beta 1, we showed that TGF-beta 1 in A673-cell-conditioned media was present in the latent, biologically inactive, form which did not act as an autocrine growth modulator of A673 cells in vitro.
Method for on-line identification of a first orderplusdead-time process model (1995)

An improved method for on-line identification of a first order plus dead-time process model under proportional-integral control is proposed. The proposed method eliminates some of the disadvantages of the Yuwana and Seborg method while retaining the simplicity of the method. Simulation results show that the proposed method performs well on a range of processes.
Taming of the Sioux (1918)

Journal Article Taming of the Sioux. By Frank Fiske. (Bismarck, North Dakota: Bismarck Tribune, 1917, 186 p. $1.50) Get access M. L. Wilson M. L. Wilson Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 5, Issue 1, June 1918, Page 110, https://doi.org/10.2307/1886249 Published: 01 June 1918
Comparative study of the effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on generation and mobilization of neutrophils in cyclophosphamide-treated neutropenic mice. (1996)

To examine the differential in vivo effects of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) on the recovery from neutropenia caused by chemotherapy, we directly compared the actions of these CSFs on neutrophil count in the bone marrow, spleen, and peripheral blood of mice treated with an anticancer drug, cyclophosphamide (CPA). Both G-CSF and GM-CSF stimulated the generation of neutrophils in bone marrow, but GM-CSF is only about 1/20 as effective as G-CSF. Both CSFs also stimulated the release of the generated neutrophils therefrom. G-CSF mobilized the neutrophils into both the circulation pool and the marginal pool, and these neutrophils were able to migrate into the inflammatory site when stimulated by casein. On the other hand, GM-CSF mobilize the neutrophils into the marginal pool but not the circulation pool, and they were not able to migrate into the inflammatory site. These findings indicate that G-CSF physiologically plays an important role as a factor which stimulates neutrophil mobilization from bone marrow into circulation as well as neutrophil generation in the bone marrow.
Fine-grain task aggregation and coordination on GPUs (2014)

In general-purpose graphics processing unit (GPGPU) computing, data is processed by concurrent threads execut-ing the same function. This model, dubbed single-instruction/multiple-thread (SIMT), requires programmers to coordinate the synchronous execution of similar opera-tions across thousands of data elements. To alleviate this programmer burden, Gaster and Howes outlined the chan-nel abstraction, which facilitates dynamically aggregating asynchronously produced fine-grain work into coarser-grain tasks. However, no practical implementation has been proposed To this end, we propose and evaluate the first channel im-plementation. To demonstrate the utility of channels, we present a case study that maps the fine-grain, recursive task spawning in the Cilk programming language to channels by representing it as a flow graph. To support data-parallel recursion in bounded memory, we propose a hardware mechanism that allows wavefronts to yield their execution resources. Through channels and wavefront yield, we im-plement four Cilk benchmarks. We show that Cilk can scale with the GPU architecture, achieving speedups of as much as 4.3x on eight compute units
Failure behaviour wellbore cement in the presence of water and supercritical CO2 (2009)

The presence of numerous abandoned wells in depleted oil and gas reservoirs might provide leakage paths thus compromising the integrity of long-term CO2 storage. However little data is available on the effect of CO2-saturated solutions on the failure behaviour of wellbore cement. Therefore, we performed triaxial compression experiments to study the effect of CO2 on the failure behaviour of Portland cement at reservoir conditions (T=80∘C, Pc=1.5 to 30 MPa). Weakening of the cement was observed due to injection of aqueous fluid, whereas addition of CO2 did not further reduce the mechanical strength of the material.
Minimally Invasive 3D Printed Fixtures for Multi Gb/s Channel Characterization with a Logic Analyzer (2020)

This paper presents a cost-effective method using 3D printing technology to reduce the parasitic losses when probing a channel with a logic analyzer compared to traditional methods. The method is demonstrated on a 16 Gb/s PCIe Gen4 channel, taking advantage of the physically accessible SMT AC decoupling capacitors through a custom fixture to contact the signals of the high-speed serial (HSS) channel. Channel topology, length and transceiver compensation, and sophisticated equalization has increased link frequency dramatically at the cost of complexity. This renders traditional debug activities using an oscilloscope to be of very limited value in the characterization and verification of the link. The protocol-awareness of HSS links, including the use of retimers, makes the use of a logic analyzer necessary. While a logic analyzer fills the need for protocol analysis and timing data to debug link errors that would be undetected by traditional oscilloscope efforts, the fixturing to contact the signals introduces an electrical loading in the channel. As data rates continue to increase, the loading becomes increasingly severe. The commonly available probe connectors for logic analyzers are physically large, require substantial board real estate, and consume a notable percentage of channel margin due to its parasitic losses. With the proposed method, HSS channels can be analyzed during link operation and link training. Prototype parts can be analyzed and, with fore-thought and planning, even failure analysis of customer-failing parts can be investigated. The fixturing is affordable, compact, and configurable using 3D printing technology promising continued use as HSS data rates continue to increase.
Characterization of 30-kDa Fragments Derived from <i>β</i>-Conglycinin Degradation Process during Germination and Seedling Growth of Soybean (1997)

The degradation process of beta-conglycinin, a vicilin-type glycosylated storage protein of soybean seeds, during germination and seedling growth was examined by concanavalin A blotting combined with polyacrylamide gel electrophoresis. We detected and analyzed the structures of key intermediary fragments of 30 kDa derived from beta-conglycinin degradation, they were proved to be single-domain type subunits of beta-conglycinin. We show here a degradation process of beta-conglycinin: beta-conglycinin is subjected to limited proteolysis at exposed regions on the molecular surface, like domain junctions, generating 30-kDa single-domain fragments before non-specific proteolysis.
[Expression of Smad4 in leukemia cells]. (2006)

Loss of transforming growth factor (TGF)-beta signaling has been implicated in malignant transformation of various tissues. Smad4 plays a central role in the signal transduction of TGF-beta. Deletion or mutation of Smad4 has been described in a number of cancers. This study was aimed to investigate a potential role of Smad4 in leukemia including its expression and location in blast cells. The mononuclear cells were separated from bone marrow of leukemia patients. The samples, blast cells of which were more than 90% in mononuclear cells, were selected. The expression and location of Smad4 protein were analyzed by immunohistochemistry methods. The results showed that the Smad4 protein located mainly in nucleus, part of this protein located in cytoplasma, the expressions of Smad4 were not detected in 6 out of 9 ALL patients, in 7 out of 24 AML patients and in 1 out of 2 CML patients; these leukemia patients, in whose cells the expression of Smad4 was not detected, included one L1 and one L3, four L2, one M0, one M1, two M2a, one M3a, one M4b, one M6 and one CML. In conclusion, the Smad4 protein was mainly in nucleus, the deletion or functional change of Smad4 may related with the pathogenesis of human AML.
Role of pertuzumab in the treatment of HER2-positive breast cancer (2012)

Pertuzumab, a humanized monoclonal antibody to the HER2 receptor, represents a promising new anti-HER2 agent with a novel mechanism of action targeting the inhibition of HER2 dimerization. Nonclinical and clinical data to date indicate that pertuzumab provides a broader HER2 blockade through the inhibition of HER2 heterodimerization. In preclinical experiments, pertuzumab has demonstrated superior antitumor effects when combined with other anti-HER2 treatments such as trastuzumab, compared to when used as monotherapy. Trastuzumab and pertuzumab monoclonal antibodies bind to distinct epitopes on the HER2 receptor without competing with each other, resulting in distinctive mechanisms for disrupting HER2 signaling. These mechanisms are complementary and result in augmented therapeutic efficacy when pertuzumab and trastuzumab are given in combination. Clinically, pertuzumab may have optimal therapeutic effects when given to patients with HER2-positive cancers, in combination with trastuzumab. This observation is supported by recent clinical trials in the metastatic as well as neoadjuvant setting. Intravenous pertuzumab had an acceptable tolerability profile when added to trastuzumab and chemotherapy. This overview will review recent advances in the clinical development of this HER2-targeted therapy.
Investigations of Pharmacologic Properties of the Renal CLC-K1 Chloride Channel Co-expressed with Barttin by the Use of 2-(p-Chlorophenoxy)Propionic Acid Derivatives and Other Structurally Unrelated Chloride Channels Blockers (2004)

CLC-K chloride channels are expressed in the kidney, where they play a pivotal role in the mechanisms of urine concentration and Na(+) reabsorption. The identification of barttin as an essential beta-subunit of CLC-K channels allowed performance of a pharmacologic characterization of wild-type CLC-K1 expressed in Xenopus oocytes. To this end, a series of 2-(p-chlorophenoxy)propionic acid (CPP) derivatives were screened using the two-microelectrode voltage-clamp technique. Several chemical modifications regarding the phenoxy group of the side chain (elimination of the oxygen atom or of methylenic groups, substitutions of the chlorine atom) did not alter the drug blocking activity, with five different derivatives showing a similar potency. Among these, a derivative of CPP carrying a benzyl group on the chiral center in the place of the methyl group represented the minimal structure for blocking CLC-K1. It inhibited the channel from the extracellular side with an affinity in the 150 micro M range. The blocking potency of this compound is fourfold increased by lowering the extracellular chloride concentration, suggesting that the drug interacts with the channel pore. Concomitantly, the effect of some "classical" Cl(-) channel blockers (9-anthracenecarboxylic acid, 2-(phenylamino)benzoic acid, iminodibenzoic acid, niflumic acid, 5-nitro-2-(3-phenylpropylamino)benzoic acid, 4,4'-diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt, and 4-acetamido-4'-isothiocyanato-2,2'-stilbenedisulfonic acid disodium salt) was screened. 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt was the only one capable of blocking CLC-K1 with a potency similar to the CPP derivative, although in an irreversible manner. The newly identified substances provide a useful tool to investigate the biophysical and physiologic role of these renal channels and a starting point for the development of therapeutic drugs with diuretic action.
A 3.9 mW 25-Electrode Reconfigured Sensor for Wearable Cardiac Monitoring System (2010)

A low power highly sensitive Thoracic Impedance Variance (TIV) and Electrocardiogram (ECG) monitoring SoC is designed and implemented into a poultice-like plaster sensor for wearable cardiac monitoring. 0.1 Ω TIV detection is possible with a sensitivity of 3.17 V/Ω and SNR > 40 dB. This is achieved with the help of a high quality (Q-factor > 30) balanced sinusoidal current source and low noise reconfigurable readout electronics. A cm-range 13.56 MHz fabric inductor coupling is adopted to start/stop the SoC remotely. Moreover, a 5% duty-cycled Body Channel Communication (BCC) is exploited for 0.2 nJ/b 1 Mbps energy efficient external data communication. The proposed SoC occupies 5 mm × 5 mm including pads in a standard 0.18 μm 1P6M CMOS technology. It dissipates a peak power of 3.9 mW when operating in body channel receiver mode, and consumes 2.4 mW when operating in TIV and ECG detection mode. The SoC is integrated on a 15 cm × 15 cm fabric circuit board together with a flexible battery to form a compact wearable sensor. With 25 adhesive screen-printed fabric electrodes, detection of TIV and ECG at 16 different sites of the heart is possible, allowing optimal detection sites to be configured to accommodate different user dependencies.
A new emissive projection display technology and a high contrast DLP projection display on black screen (2011)

In this paper, Sun Innovations demonstrates an innovative emissive projection display (EPD) system. It is comprised of a fully transparent fluorescent screen with a UV image projector. The screen can be applied to glass windows or windshield, without affecting visible light transmission. The UV projector can be based on either a DLP (digital light processor) or a laser scanner display engine. For a DLP based projector, a discharge lamp coupled to a set of UV filters can be applied to generate a full color video image on the transparent screen. UV or blue-ray laser diodes of different wavelengths can be combined with scanning mirrors to generate a vector display for full windshield display applications. This display combines the best of both worlds of conventional projection and emissive display technologies. Like a projection display, the screen has no pixel structure and can be manufactured roll to roll; the display is scalable. Like an emissive display (e.g. plasma or CRT), the quality of the image is superior, with very large viewing angles. It also offers some unique features. For example, in addition to a fully transparent display on windows or windshields, it can be applied to a black substrate to create the first front projection display on true "black" screen that has superior image contrast at low projection power. This fundamentally new display platform can enable multiple major commercial applications that can not be addressed by any of the existing display technologies.