gebhart/patrepeval huggingface dataset:
Formation of Tubular Crimp Connections: Elementary Considerations (2008)

The paper reviews the fundamental principles of mechanical crimp connections and provides a simple predictive model for achieving acceptable tubular crimps with a solid conductor. This model is based on well- established strain-strain relationships of cylindrical bodies in elasticity mechanics. The model is used to relate the residual contact load in the crimp junction to the mechanical yield strength and elastic springback properties of both the conductor and the crimp barrel. It is shown that the relative yield strength and relative elastic modulus of the materials in contact must meet specific conditions to achieve a crimp junction with acceptable strength and electrical contact resistance. The paper also provides an explanation for the minimum compaction required to achieve a reliable electrical crimp connection in stranded wire connections.
Substrate loss reduction in antenna-on-chip design (2009)

We have explained the effect of the silicon substrate on the off-chip radiation of an integrated antenna on chip. From this consideration a low-cost approach for an enhanced antenna-on-chip design has been derived and its improved radiation efficiency has been confirmed by measurements.
Eribulin mesylate for the treatment of breast cancer (2010)

Based on data from Phase I and II clinical trials, we conclude that eribulin seems to have efficacy in metastatic breast cancer, even among women with heavily pretreated and taxane-resistant disease. In addition, eribulin has a manageable side-effect profile, consisting mainly of neutropenia and fatigue, and most notably a low incidence of peripheral neuropathy. With these encouraging results, additional Phase II and III studies are ongoing. Eribulin seems to be a promising new agent for the treatment of metastatic breast cancer.
Targeting cancer using cholesterol conjugates (2013)

Conjugation of cholesterol moiety to active compounds for either cancer treatment or diagnosis is an attractive approach. Cholesterol derivatives are widely studied as cancer diagnostic agents and as anticancer derivatives either in vitro or in vivo using animal models. In largely growing studies, anticancer agents have been chemically conjugated to cholesterol molecules, to enhance their pharmacokinetic behavior, cellular uptake, target specificity, and safety. To efficiently deliver anticancer agents to the target cells and tissues, many different cholesterol-anticancer conjugates were synthesized and characterized, and their anticancer efficiencies were tested in vitro and in vivo.
Multivalent DNA Vaccine Enhanced Protection Efficacy against Infectious Bronchitis Virus in Chickens (2009)

For efficacious DNA vaccine development against infectious bronchitis virus (IBV), the immunogenicity of a multivalent DNA vaccine was evaluated. Three expression plasmids each targeting spike protein (S1), nucleocapsid protein (N), and membrane protein (M) of IBV were prepared. Chickens were immunized with either individual plasmids (monovalent) or with a combination of all plasmids (multivalent). Immunization with the multivalent DNA vaccine induced synergistic augmentation of humoral and cellular responses in comparison with the individual vaccines, and provided up to 85% immune protection. Thus the multivalent DNA vaccine represents an innovative approach for enhancing DNA vaccine potency, and has potential clinical application for vaccination against IBV.
A Clinical approach to marital problems: Evaluation and management (1974)

(1974). A Clinical approach to marital problems: Evaluation and management. Journal of Family Counseling: Vol. 2, No. 1, pp. 65-67.
Phase 1 trial of everolimus plus sunitinib in patients with metastatic renal cell carcinoma (2011)

The combination of everolimus and sunitinib is associated with significant acute and chronic toxicities and is only tolerated at attenuated doses. Responses were observed in nonclear cell and clear cell RCC.
The amino‐acid sequence of the abalone (<i>Haliotis laevigata</i>) nacre protein perlucin (2000)

Perlucin isolated from abalone nacre consists of 155 amino acids including a glycosylated asparagine. The sequence of the first 130 amino acids shows a high similarity to the C-type carbohydrate-recognition domains of asialoglycoprotein receptors and other members of the group of C-type lectins but also a weaker similarity to related proteins without carbohydrate-binding activity. This C-type module is followed by a short C-terminal domain containing two almost identical sequence repeats with a length of 10 amino acids. Solid phase assays show a divalent metal ion-dependent binding of perlucin to (neo)glycoproteins containing D-galactose or D-mannose/D-glucose indicating that perlucin is a functional C-type lectin with broad carbohydrate-binding specificity. Our results also indicate that it may be difficult to predict carbohydrate-binding specificity and the occurrence of alternative binding configurations by amino-acid sequence comparisons and homology modeling.
Document Retention and Destruction: Practical, Legal, and Ethical Considerations (1980)

Justice Frankfurter observed: Virtually every major public law enactment-to say nothing of State and local legislation-has record-keeping provisions.In addition to record-keeping requirements, is the network of provisions for filing reports.Exhaustive efforts would be needed to track down all the statutory authority, let alone the administrative regulations, for record-keeping and reporting requirements.Unquestionably they are enormous in volume.Id. at 51. 11 In United States v. Darby, 312 U.S. 100 (1940), the Court upheld the validity of the record-keeping requirements of the wage and hour provisions of the Fair
Lysosomal Enzyme Precursors in Human Fibroblasts. Activation of Cathepsin D Precursor in vitro and Activity of beta-Hexosaminidase A Precursor towards Ganglioside GM2 (1982)

Precursors of cathepsin D and beta-hexosaminidase were isolated from secretions of human fibroblasts and their activity was studied with natural substrates. The immunoprecipitated precursor of cathepsin D, Mr 53000, was inactive with radioactive hemoglobin as substrate. At pH 3.8-4.2 an activation of the precursor took place, which was correlated by a reduction in size to Mr 51500. The observed cleavage of cathepsin D precursor in vitro resembles the autocatalytic activation of pepsinogen. The precursor of beta-hexosaminidase A is able to cleave the natural substrate GM2 ganglioside. This reaction, like that of the mature enzyme, depends on the presence of a protein activator, which interacts with the substrate and the enzyme.
A Scheme to Compensate Time Drift in Time Difference of Arrival Localization Among Non-Synchronized Sensor Nodes (2009)

Ranging and localization are some of the key applications in a wireless sensor network. Good accuracy can be obtained if the signals captured are of good qualities. In a practical scenario, crystal clock timing drift in the devices in a wireless sensor network will greatly influence the ranging and localization accuracy. In this paper, we shall use Time Difference of Arrival technique to determine the locations of the devices. In particular, we will highlight the importance of time drift in affecting the accuracy of location determinations and proposed a scheme to overcome time drift when performing Time Difference of Arrival localization. In addition, we will also estimate the devices transmit time offset so that we can compensate this value from the range information. In this way, there is no requirement for the sensor nodes to be synchronized initially.
Flexible extrinsic calibration of a camera and a two-dimensional laser rangefinder with a folding pattern (2016)

This paper proposes a novel folding pattern for flexible extrinsic calibration of a camera and a 2D laser rangefinder (LRF). The proposed pattern consists of multiple foldable facets. By folding and unfolding the facets, we can easily adjust the sizes and expanding angles of the pattern so that it can be observed by sensors with different view angles at different distances. Moreover, the folding pattern can have different numbers of facets such that it can flexibly generate different constraints to simplify the calibration process. The proposed pattern is thus very flexible and practical. Another important feature is that the proposed method does not require computing the metric information of the pattern, such as plane normal and distance, as required in existing methods. Therefore, it can further simplify the calibration process and enhance the calibration accuracy. In this method, we first derived a linear solution, and then refined the solution with the particle swarm optimization (PSO) method by both enforcing the rotation constraint and minimizing the sum of the square of the point-to-line distances. The proposed calibration pattern and method have been validated with both simulation and real data. Experimental results show that the method is very flexible and accurate for the extrinsic calibration of a camera and a 2D LRF.
Predicting system-level area and delay for pipelined and nonpipelined designs (1992)

The ability to predict area-delay characteristics of designs without actually implementing them is important in producing quality designs in a reasonable time. A mathematical model for predicting the area-delay tradeoff curve for pipelined and nonpipelined data paths, given a data flow graph and a choice of module styles, is proposed. The model has been validated against designs generated by pipelined and nonpipelined data-path synthesis programs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
DNA-based asymmetric catalysis (2010)

The unique chiral structure of DNA has been a source of inspiration for the development of a new class of bio-inspired catalysts. The novel concept of DNA-based asymmetric catalysis, which was introduced only five years ago, has been applied successfully in a variety of catalytic enantioselective reactions. In this tutorial review, the ideas behind this novel concept will be introduced, an overview of the catalytic chemistry available to date will be given and the role of DNA in catalysis will be discussed. Finally, an overview of new developments of potential interest for DNA-based asymmetric catalysis will be provided.
Atomically accurate Si grating with 5.73 nm period (2001)

A vicinal surface of silicon is found that exhibits an atomically accurate step pattern with a period of 5.73 nm, corresponding to 17 atomic rows per (111) terrace. It can be viewed as reconstructed Si(557) surface, where a triple step is combined with a single Si(111)7×7 unit. The driving forces for establishing regular step patterns are discussed.
Lipopolysaccharide‐induced tyrosine nitration and inactivation of hepatic glutamine synthetase in the rat† ‡ (2005)

Glutamine synthetase (GS) in the liver is restricted to a small perivenous hepatocyte population and plays an important role in the scavenging of ammonia that has escaped the periportal urea-synthesizing compartment. We examined the effect of a single intraperitoneal injection of lipopolysaccharide (LPS) in vivo on glutamine synthesis in rat liver. LPS injection induced expression of inducible nitric oxide synthase, which was maximal after 6 to 12 hours but returned toward control levels within 24 hours. Twenty-four hours after LPS injection, an approximately fivefold increase in tyrosine-nitrated proteins in liver was found, and GS protein expression was decreased by approximately 20%, whereas GS activity was lowered by 40% to 50%. GS was found to be tyrosine-nitrated in response to LPS, and immunodepletion of tyrosine-nitrated proteins decreased GS protein by approximately 50% but had no effect on GS activity. Together with the finding via mass spectrometry that peroxynitrite-induced inactivation of purified GS is associated with nitration of the active site tyrosine residue, our data suggest that tyrosine nitration critically contributes to inactivation of the enzyme. In line with GS inactivation, glutamine synthesis from ammonia (0.3 mmol/L) in perfused livers from 24-hour LPS-treated rats was decreased by approximately 50%, whereas urea synthesis was not significantly affected. In conclusion, LPS impairs hepatic ammonia detoxification by both downregulation of GS and its inactivation because of tyrosine nitration. The resulting defect of perivenous scavenger cell function with regard to ammonia elimination may contribute to sepsis-induced development of hyperammonemia in patients who have cirrhosis.
Solution Assembled and Microcontact Printed Monolayers of Dodecanethiol on Gold:  A Multivariate Exploration of Chemistry and Contamination (2002)

Self-assembled monolayers (SAMs) of dodecanethiol on gold formed by solution assembly and microcontact printing were compared using electron spectroscopy for chemical analysis (ESCA) and time-of-flight secondary ion mass spectrometry (SIMS). Both univariate (ESCA and TOF-SIMS) and multivariate (TOF-SIMS) analysis techniques were employed. Univariate analysis showed that samples stamped with a thiol concentration >10−50 mM produced SAMs comparable to long solution assembly times. Principal component analysis (PCA) of the SIMS spectra provided deeper insight into the two sets of samples. The scores from the first principal component (PC1) showed similarities between the samples prepared by the two methods, though there was more scatter in the microcontact printed samples. The second principal component (PC2) showed that differences exist between the solution assembled and stamped samples due mainly to a relative increase in the presence of oxidized species (SO3-, HSO4-, O-, OH-, (M−H)-oxidized) and silicone contaminants on the stamped samples. This is in contrast to the univariate data that showed only random trace amounts of Si (<1%) by ESCA analysis on a few spots sampled. Information from this study was used to suggest ways of minimizing surface contamination in microcontact printing of thiols. We suggest extensive precleaning of the stamp and use of higher thiol ink concentrations (at least 10−50 mM).
Tumor-Treating Fields: A Fourth Modality in Cancer Treatment (2017)

Despite major advances in therapy, cancer continues to be a leading cause of mortality. In addition, toxicities of traditional therapies pose a significant challenge to tolerability and adherence. TTFields, a noninvasive anticancer treatment modality, utilizes alternating electric fields at specific frequencies and intensities to selectively disrupt mitosis in cancerous cells. TTFields target proteins crucial to the cell cycle, leading to mitotic arrest and apoptosis. TTFields also facilitate an antitumor immune response. Clinical trials of TTFields have proven safe and efficacious in patients with glioblastoma multiforme (GBM), and are FDA approved for use in newly diagnosed and recurrent GBM. Trials in other localized solid tumors are ongoing. <i>Clin Cancer Res; 24(2); 266-75. ©2017 AACR</i>.
Controlled Intersymbol Interference Design Techniques of Conventional Interconnect Systems for Data Rates Beyond 20 Gbps (2008)

This paper presents a new design technique of high-speed interconnects with controlled intersymbol interference (ISI) to create efficient signaling over a band-limited channel. Performance of high-speed electrical links is limited by conductor loss, dielectric dispersion, and reflections in the board, package, and connector. These nonidealities result in significant ISI. In current systems, the effect of ISI is either mitigated through complex equalization, signal conditioning, and coding techniques, or through costly impedance control and manufacturing processes. In the proposed approach, instead of eliminating ISI, we shape the response of the channel into a set of channel characteristics with controlled ISI using simple passive structures in the board and the package. The resulting controlled ISI is exploited at the transmitter and receiver to simplify the architecture of the system and to achieve high data rates. The techniques to design interconnects with controlled ISI are reasonably simple to implement in conventional interconnect technologies. Simulation examples are given to demonstrate the validity and advantages of the design technique using duobinary and analog multitone (AMT) signaling methods.
Fabio Cupaiuolo: Tra poesia e poetica: su alcuni aspetti culturali delta poesia latina nell'etá augustea. (Collana di Studi Latini, xv.) Pp. 280. Naples: Libreria Scientifica Editrice, 1966. Paper, <i>L</i>. 5,000. (1969)

Fabio Cupaiuolo: Tra poesia e poetica: su alcuni aspetti culturali delta poesia latina nell'etá augustea. (Collana di Studi Latini, xv.) Pp. 280. Naples: Libreria Scientifica Editrice, 1966. Paper, L. 5,000. - Volume 19 Issue 2
ANN, ARIMA and MA timeseries model for forecasting in cement manufacturing industry: Case study at lafarge cement Indonesia &#x2014; Aceh (2014)

The accurate demand forecast method is one of the main important to industry to minimize error. In this study tried to propose the Artificial Neural Network (ANN), Arima and Moving Average (MA) to predict the condition of sale demand in cement manufacturing industry. The predicted months after the twenty two at the last months data and should be validated with the real two months data. The processes come from collecting sales real data from cement industry in aceh province. Analyzed the predicted condition and the mean square error (MSE), MAPE and SSE. Compared to the installed method in the factory should be also considered. The result of this study ANN, Arima and MA models are better than the installed method and the predicted data are better as well where the installment produce more than thirty percent errors.
Cost Effectiveness of Rivaroxaban versus Warfarin to Prevent Stroke in Iranian AF Patients (2020)

Background and objectives: Atrial fibrillation (AF) is the most common sustained arrhythmia in adults which need anti-coagulant to prevent stroke. Due to high cost of Rivaroxaban compared to warfarin, it`s not prescribed as much as warfarin by physicians despite its superiority in intracranial hemorrhage. Therefore, this study aimed to evaluate the cost-effectiveness of rivaroxabane versus warfarin in preventing stroke in AF patients.
Methods: This study is a cost-utility analysis with cost-effectiveness assessed by the incremental cost per quality-adjusted life-year (QALY). Two strategies were used to obtain the costs; the first was from available resources and the next was to collect data using a questionnaire. Utility values for obtaining ∆QALYs were sourced from published data. Finally the cost-effectiveness of Warfarin versus Rivaroxaban was assessed using an incremental cost-effectiveness ratio (ICER), which was calculated as the incremental cost per QALY (Quality-adjusted life year) gained.
Results: A total number of 98 patients who met the inclusion criteria were answered the questionnaire. Mean annually physician visits were 4 times in rivaroxaban and 14 times in warfarin group. The patients in Warfarin Group checked their INR (international normalised ratio) 15 times a year, while the patients in Rivaroxaban group did not check at all. The wasting time for each physician visit and doing Lab test was approximately 3 hour. Total cost of Rivaroxaban in both private (16699000IRR) and public services (15755000IRR) were less than Warfarin in both private and public services (24233700 & 20345600 IRR). We analyzed the ΔQALYs of 7 different articles in which the mean ΔQALY was 0.21 (Variance: 0.0072). The Incremental cost per QALY per patient for warfarin in Private versus public services was 18514762 Rial /QALY, while the ICER between Rivaroxaban versus warfarin in both private and Public services was negative                                   (-35879523.8 and -21860000 Rial/QALY). So the calculated threshold based on the per capita gross national product (GDP), which was 702576000 Rials (calculated at 42,000IRR/$), showed that Rivaroxaban is more cost-effective than Warfarin.
Conclusions The results of present study demonstrated that use of Rivaroxaban versus Warfarin in both public and private services is a cost-effective choice. So, due to its economic and potential benefits, it is recommended to prescribe Rivaroxaban rather than warfarin.
Comparison of bifidobacterial growth-promoting activity of ultrafiltered casein hydrolyzate fractions (1994)

Growth rates and acid production of the most common dairy-related bifidobacteria (Bifidobacterium infantis, B breve and B longum) were determined in the presence of casein hydrolyzates produced by the action of three proteolytic enzymes (alcalase, chymotrypsin and trypsin). Casein hydrolyzates were fractionated with a two-step ultrafiltration process to study the effect of molecular mass of peptides on bifidobacterial growth. The retentate of the second ultrafiltration (nominal molecular eut-off of membranes was 1000 Da) was called mixture of polypeptides (MP) and the permeate fraction which was mainly composed of free amino acids and small peptides was called AA. These hydrolyzate fractions were characterized by a very different concentration of some amino acids (glu, tyr, phe). Among MP and AA casein fractions, trypsin MP fraction at a final concentration of 2% in synthetic medium (Garches medium) exhibited a higher growth-promoting activity on the three bifidobacterial species tested. However, addition of alcalase AA fraction at a final concentration of 1 or 2% repressed the growth and acid production of B breve and B longum. bifidobacteria 1 casein hydrolyzate fraction 1 amino acid content 1 stimulation Rsum -Comparaison de l'activit stimulante sur la croissance des bifidobactries de fractions ultrafiltres d'hydrolysats casiques. Les taux de croissance et l'activit acidifiante de souches de bifidobactries communment utilises en industrie laitire (Bifidobacterium infantis, B breve et B longum) ont t estims en prsence d'hydrolysats enzymatiques de casine obtenus en utilisant l'alcalase, la chymotrypsine et la trypsine. Les hydrolysats de casine ont t spars en 2 fractions distinctes grce un procd d'ultrafiltration en 2 tapes, afin d'tudier l'influence de la masse molculaire des peptides sur la croissance des bifidobactries. La fraction rtentat de la seconde tape d'ultrafiltration (seuil de coupure des membranes de 1 000 Da) correspondait au mlange polypeptidique (MP) et le filtrat fut identifi comme un mlange de peptides de faible masse molculaire et d'acides amins libres (AA). Ces fractions d'hydrolysat sont caractrises par Correspondence and reprints M Proulx et al une concentration trs diffrente de certains acides amins (glu, tyr, phe). Parmi les fractions MP et AA des diffrents hydrolysats casiques, l'hydrolysat trypsique MP ajout un milieu synthtique (milieu Garches) une concentration finale de 2% a un effet stimulant suprieur sur la croissance des 3 espces de bifidobactries testes. La croissance et la production d'acide de B breve et B longum ont t inhibes par l'ajout de la fraction AA de l'hydrolysat alcalasique une concentration finale de 1 ou 2%.