gebhart/patrepeval huggingface dataset:
In Vitro Antimicrobial Activity of Doripenem, a New Carbapenem (2004)

The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 microg/ml for 10 species of Enterobacteriaceae (n = 351), from 0.03 to 0.12 microg/ml for oxacillin-susceptible staphylococci (n = 119), from 4 to 32 microg/ml for oxacillin-resistant staphylococci (n = 64), from < or =0.008 to 0.06 microg/ml for penicillin-susceptible streptococci (n = 132), and from 1 to 4 microg/ml for penicillin-resistant streptococci (n = 51). Overall, doripenem demonstrated in vitro activity similar to that of meropenem against gram-negative pathogens and to that of imipenem against gram-positive pathogens.
The principles and advances of quantitative pathology. (1987)

This article gives an overview of the quantitative pathologic techniques used today, with special emphasis on interactive morphometry and its application in the clinical setting. At present, stereologic calculations may be necessary, but in a diagnostic setting have only rarely proved to be essential. The reproducibility of the measurements is discussed in relation to the definition of the particles and staining methods. A number of technical factors that cause random errors are mentioned, such as quality of the slides, magnification, definition of the particles to be measured and measuring protocol. Large-scale experiments have revealed that the means of nuclear morphometric and certain stereologic features are reproducible, such as in the volume percentage of epithelium, the surface densities of glands and the mitotic activity index. The diagnostic applications of the standard deviation and shape factors of nuclear quantitative features require additional precautions, however. Having quantified cell and tissue features, multivariate analysis may result in a better discrimination of two or more groups under study. The quantitative pathologic examination of cells and tissues can provide important diagnostic and prognostic information. Quantitation in pathology is especially useful in so-called continuous lesions, in which interobserver and intraobserver disagreement is considerable. An important requirement of diagnostic morphometry is object selection by a skilled pathologist; the use of morphometry as a black box can result in dramatic errors. The criteria used for a morphometric classification rule that can be used for clinical applications are summarized. Quality control of the whole measuring system is essential. Application of these techniques for more than six years in diagnostic pathology has repeatedly corrected previous qualitative diagnoses.(ABSTRACT TRUNCATED AT 250 WORDS)
Microfluidic Electrocapture for Separation of Peptides (2005)

A separation method based on electroimmobilization and sequential release of captured molecules is reported. A microfluidic electrocapture device is utilized to immobilize peptides in a microflow stream. After capture, the electric field is decreased in a stepwise manner, causing sequential release of the captured peptides according to their electrophoretic mobility. Tryptic peptides were separated and analyzed by matrix-assisted laser desorption/ionization mass spectrometry. The separation power was high enough to increase the ionization yield of several peptides not seen in the unprocessed sample. In addition to separation, simultaneous sample cleanup was demonstrated for peptides obtained by shotgun tryptic digestion of membrane protein extracts.
Nitrous oxide (N <sub>2</sub> O) processing for silicon oxynitride gate dielectrics (1999)

The gas-phase chemistry of silicon oxynitridation in N <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O has been investigated. From an evaluation of available kinetic data, we have developed a model for the thermal decomposition of gaseous N <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O. To quantify heat transfer between the N <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O gas and the wall of the furnace, we introduce the concept of referencing to an N <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> gas-temperature profile, measured in an oxidation furnace. Using this model, we can account for the increase with flow rate and temperature of the NO concentration in the N <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O decomposition product, and the self-heating during decomposition, for furnace processing. This change in gaseous NO concentration translates to a higher nitrogen content and lower growth rate for the silicon oxynitride. For rapid thermal and other short-gas-residence-time systems, we show that atomic oxygen is present at the Si wafer, and that this removes previously incorporated nitrogen.
Studies of the Optical Properties of Metal-Pliable Polymer Composite Materials (2003)

Polymer-nano-metallic-particle composites have demonstrated technological potential due to their unique optical and electrical properties. Herein, we report on composites prepared via physical vapor deposition of silver metal onto pliable poly(dimethylsiloxane) (PDMS) polymer. Rapid Ag diffusion and nano-metallic-particle formation in a phase-separated surface layer of the PDMS creates unique sub-surface-based composites whose properties vary based on rate of deposition and average Ag thickness. Additionally, nanometallic-particle spacing can be altered with fair reproducibility and reversibility by physically manipulating the Ag-PDMS composite. The optical properties of the materials are studied by visible wavelength optical extinction spectrometry and surface-enhanced Raman scattering (SERS), including studies performed during physical manipulation. Direct current (DC) conductivity measurements were made during Ag deposition to study percolation conditions for the materials. Depth-profiling was performed by X-ray photoelectron spectrometry. Sample Raman spectral data collected with the composite as a SERS substrate are included. A practical technological characteristic of these composite materials arises from their potential to be molded into functional devices.
US data show sharply rising drug-induced death rates: Figure 1 (2007)

Substantial numbers of deaths are related to disease and injury resulting from the use of drugs, alcohol and firearms worldwide. Death rates associated with these exposures were compared with those from motor vehicle crashes in the US from 1979 to 2003 by race. Among Caucasians, drug-induced death rates rose sharply after 1990 and surpassed deaths involving alcohol and firearms in 2001 and 2002, respectively. Among African-Americans, drug-induced deaths surpassed alcohol-induced deaths for the first time in 1999.
A Method to Examine the Impact of Grid Connection of the DFIGs on Power System Electromechanical Oscillation Modes (2015)

Grid connection of a DFIG for power generation changes the power system load flow and introduces dynamic interactions with the synchronous generators (SGs). A method is proposed in this paper for the separate examination of the impact of those two affecting factors, the change of load flow and dynamic interaction brought about by the DFIG, on the electromechanical oscillation modes of a power system. The method is developed on the establishment of a “closed-loop control system” type of state space model of the power system where the DFIG is treated as the feedback controller. The established model unambiguously indicates that the impact of the DFIG can be examined separately: (1) With the DFIG being modelled as a constant power injection into the system, the impact of the load flow change brought about by the DFIG on the oscillation modes is determined; (2) The impact of the dynamic interactions introduced by the DFIG is estimated by calculating the contribution of the damping torque from the DFIG with its full dynamics being considered. Thus a more detailed examination on and deeper insight into the impact of grid connection of the DFIGs on power system small-signal angular stability is obtained by using the proposed method.
Generation of graphene-based aerogel microspheres for broadband and tunable high-performance microwave absorption by electrospinning-freeze drying process (2017)

Despite recent progress in the synthesis and application of graphene-based aerogels, some challenges such as scalable and cost-effective production, and miniaturization still remain, which hinder the practical application of these materials. Here we report a large-scale electrospinning method to generate graphene-based aerogel microspheres (AMs), which show broadband, tunable and high-performance microwave absorption. Graphene/Fe3O4 AMs with a large number of openings with hierarchical connecting radial microchannels can be obtained via electrospinning-freeze drying followed by calcination. Importantly, for a given Fe3O4:graphene mass ratio, altering the shape of aerogel monoliths or powders into aerogel microspheres leads to unique electromagnetic wave properties. As expected, the reflection loss of graphene/Fe3O4 AMs-1:1 with only 5 wt.% absorber loading reaches −51.5 dB at 9.2 GHz with a thickness of 4.0 mm and a broad absorption bandwidth (RL < −10 dB) of 6.5 GHz. Furthermore, switching to coaxial electrospinning enables the fabrication of SiO2 coatings to construct graphene/Fe3O4@SiO2 core‒shell AMs. The coatings influence the electromagnetic wave absorption of graphene/Fe3O4 AMs significantly. In view of these advantages, we believe that this processing technique may be extended to fabricate a wide range of unique graphene-based architectures for functional design and applications.
Feasibility of Application Containers in Embedded Real-Time Linux (2018)

Virtualization offers many benefits like information security and compatibility issue fixing. This technology is, however, not traditionally used in embedded systems due to the overhead it produces. Today’s embedded systems have more processing power than the systems in the past and container technology provides a low overhead solution for virtualization making virtualization possible for embedded devices.\nThe aim of this thesis was to study the feasibility of container-based virtualization in embedded real-time Linux. The test system was an embedded real-time Linux device used for Internet-of-Things solutions. The container technology used in the thesis was Docker. Docker was chosen as it has a comprehensive documentation and has been broadly adopted by the industry.\nThe feasibility was studied by measuring the performance and comparing these results to other studies and reading information security and software management documentation. The performance measurements considered POSIX inter-process communication latency, memory consumption and mass storage usage. The measurements were performed with both containerized and non-containerized systems to contrast the results. Information security and software management aspects were studied by inspecting documentation.\nThe measurements showed that the latency is not affected by the virtualization, memory consumption is slightly larger and the mass storage usage is considerably larger and should be taken into account when planning the virtualization. Containers were also perceived to help with information security and make software management easier. The information security of the containers should not, however, be carelessly trusted.
Oxide Interfaces—An Opportunity for Electronics (2010)

Extraordinary electron systems can be generated at well-defined interfaces between complex oxides. In recent years, progress has been achieved in exploring and making use of the fundamental properties of such interfaces, and it has become clear that these electron systems offer the potential for possible future devices. We trace the state of the art of this emerging field of electronics and discuss some of the challenges and pitfalls that may lie ahead.
PRESCRIBING FOR PRESBYOPIA WITH CONTACT LENSES (1967)

London, England *Submitted on June 1, 1966, for publication in the November. 1967. issue of the American Journal of Optometry and Archives of American Academy of Optometry. The substance of this paper was presented at the Harrogate (U.K., 1965) and the Royaumont (France, May, 1966) congresses. †Optometrist. Fellow, American Academy of Optometry.
Security Issues in Cloud Computing (2013)

Cloud computing allows on-demand provisioning of computing services. Despite the many advantages, the cloud computing environment faces many security challenges. This paper reviews major security issues arising in the cloud computing environment owing to computation outsourcing, multi-tenancy and broad network access. Notable research in the area is summarized. A set of recommendations for secure deployment on the cloud is also included.
Automated Systolic Array Architecture Synthesis for High Throughput CNN Inference on FPGAs (2017)

Convolutional neural networks (CNNs) have been widely applied in many deep learning applications. In recent years, the FPGA implementation for CNNs has attracted much attention because of its high performance and energy efficiency. However, existing implementations have difficulty to fully leverage the computation power of the latest FPGAs. In this paper we implement CNN on an FPGA using a systolic array architecture, which can achieve high clock frequency under high resource utilization. We provide an analytical model for performance and resource utilization and develop an automatic design space exploration framework, as well as source-to-source code transformation from a C program to a CNN implementation using systolic array. The experimental results show that our framework is able to generate the accelerator for real-life CNN models, achieving up to 461 GFlops for floating point data type and 1.2 Tops for 8-16 bit fixed point.
Macroeconomic implications of factor substitution in industrial processes (1980)

This paper examines the scope for capital-labor substitution in the LDCs. It addresses three principal questions: How do the benefits to private producers of systematically adopting appropriate technology compare with those of adopting capital-intensive technology? How surmountable are the obstacles to adopting appropriate technology that is available? If the benefits of adopting appropriate technology are great and the obstacles surmountable, why are LDC producers opting for capital-intensive processes? The analysis relies on engineering-economic analyses to answer the first question; a reformulation of obstacles in a cost-benefit framework to answer the second; and a discussion of alternative profit-seeking activities of producers to answer the third.
Cetuximab delivery and antitumor effects are enhanced by mild hyperthermia in a xenograft mouse model of pancreatic cancer (2016)

Even with current promising antitumor antibodies, their antitumor effects on stroma-rich solid cancers have been insufficient. We used mild hyperthermia with the intent of improving drug delivery by breaking the stromal barrier. Here, we provide preclinical evidence of cetuximab + mild hyperthermia therapy. We used four in vivo pancreatic cancer xenograft mouse models with different stroma amounts (scarce, MIAPaCa-2; moderate, BxPC-3; and abundant, Capan-1 and Ope-xeno). Cetuximab (1 mg/kg) was given systemically, and the mouse leg tumors were concurrently heated using a water bath method for 30 min at three different temperatures, 25°C (control), 37°C (intra-abdominal organ level), or 41°C (mild hyperthermia) (n = 4, each group). The evaluated variables were the antitumor effects, represented by tumor volume, and in vivo cetuximab accumulation, indirectly quantified by the immunohistochemical fluorescence intensity value/cell using antibodies against human IgG Fc. At 25°C, the antitumor effects were sufficient, with a cetuximab accumulation value (florescence intensity/cell) of 1632, in the MIAPaCa-2 model, moderate (1063) in the BxPC-3 model, and negative in the Capan-1 and Ope-xeno models (760, 461). By applying 37°C or 41°C heat, antitumor effects were enhanced shown in decreased tumor volumes. These enhanced effects were accompanied by boosted cetuximab accumulation, which increased by 2.8-fold (2980, 3015) in the BxPC-3 model, 2.5- or 4.8-fold (1881, 3615) in the Capan-1 model, and 3.2- or 4.2-fold (1469, 1922) in the Ope-xeno model, respectively. Cetuximab was effective in treating even stroma-rich and k-ras mutant pancreatic cancer mouse models when the drug delivery was improved by combination with mild hyperthermia.
Creating optical filters with angular-selective light transmission (2015)

A simple method for designing and calculating grating optical filters with angular-selective light transmission is presented. The selectivity is provided by the relative positions of two surface gratings formed by directionally transmissive strips, alternating with absorptive, reflective, or scattering strips. As the incidence angle changes, the proportion of radiation that passes through both gratings also changes. Geometric and optical filter parameters are calculated to achieve a light transmittance with a predetermined angular dependence. This method can be used to create neutral-density, frequency, and spatial filters pre-adapted to incidence angles that change when the light source moves relative to the filter.
Using cpsA–cpsB sequence polymorphisms and serotype-/group-specific PCR to predict 51 Streptococcus pneumoniae capsular serotypes (2003)

Streptococcus pneumoniae polysaccharide and protein-conjugate vaccines are available against the most commonly isolated pneumococcal serotypes. Ongoing surveillance of invasive pneumococcal disease is needed in order to monitor changes in distribution of serotypes. Based on previously published sequences of capsular polysaccharide synthesis (cps) gene clusters of 16 pneumococcal serotypes, a molecular capsular typing (MCT) system has been developed, based on a combination of partial cpsA-cpsB sequencing and serotype- or serogroup-specific PCR, targeting the genes wzy and wzx (except for serotype 3). In this study, 151 S. pneumoniae isolates of known serotype (representing 51 serotypes) and 276 recent clinical isolates were used to develop MCT and compare it with conventional serotyping (CS) (total 427 isolates). On the basis of 376 heterogeneity sites in the cpsA-cpsB region, 89 sequence types (ST) were identified, of which 76 corresponded to a single serotype and 11 contained two serotypes. The correct serotypes in two of the latter (10A-23F-g and 23F-23A) were identified using serotype 23F-specific PCR. Limited CS was required for 92 (22 %) isolates to distinguish between the two serotypes in the nine other mixed ST (6A-6B-g, 6A-6B-q, 15B-22F, 33F-33A, 17F-35B, 18B-18C, 13-20, 25F-38, 31-42). MCT is a specific, objective and practical method that can predict the serotype of most S. pneumoniae isolates; it will facilitate epidemiological studies. Further study of the relationship between MCT and CS is needed in order to improve our understanding of serotype differentiation and to improve MCT methods further.
Structural characterization of the lipid A component of Helicobacter pylori rough- and smooth-form lipopolysaccharides (1997)

The chemical structure of free lipid A isolated from rough- and smooth-form lipopolysaccharides (R-LPS and S-LPS, respectively) of the human gastroduodenal pathogen Helicobacter pylori was elucidated by compositional and degradative analysis, nuclear magnetic resonance spectroscopy, and mass spectrometry. The predominant molecular species in both lipid A components are identical and tetraacylated, but a second molecular species which is hexaacylated is also present in lipid A from S-LPS. Despite differences in substitution by acyl chains, the hydrophilic backbone of the molecules consisted of beta(1,6)-linked D-glucosamine (GlcN) disaccharide 1-phosphate. Because of microheterogeneity, nonstoichiometric amounts of ethanolamine-phosphate were also linked to the glycosidic hydroxyl group. In S-LPS, but not in R-LPS, the hydroxyl group at position 4' was partially substituted by another phosphate group. Considerable variation in the distribution of fatty acids on the lipid A backbone was revealed by laser desorption mass spectrometry. In tetraacyl lipid A, the amino group of the reducing GlcN carried (R)-3-hydroxyoctadecanoic acid (position 2), that of the nonreducing GlcN carried (R)-3-(octadecanoyloxy)octadecanoic acid (position 2'), and ester-bound (R)-3-hydroxyhexadecanoic acid was attached at position 3. Hexaacyl lipid A had a similar substitution by fatty acids, but in addition, ester-bound (R)-3-(dodecanoyloxy)hexadecanoic acid or (R)-3(tetradecanoyloxy)hexadecanoic acid was attached at position 3'. The predominant absence of ester-bound 4'-phosphate and the presence of tetraacyl lipid A with fatty acids of 16 to 18 carbons in length differentiate H. pylori lipid A from that of other bacterial species and help explain the low endotoxic and biological activities of H. pylori LPS.
Phase-Locked Loops for Wireless Communications (2002)

Phase-Locked Loops for Wireless Communications: Digitial, Analog and Optical Implementations, Second Edition presents a complete tutorial of phase-locked loops from analog implementations to digital a
Chemical Kinetic Mechanism for Atmospheric Chromium (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical Kinetic Mechanism for Atmospheric ChromiumChristian. Seigneur and Elpida. ConstantinouCite this: Environ. Sci. Technol. 1995, 29, 1, 222–231Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/es00001a029https://doi.org/10.1021/es00001a029research-articleACS PublicationsRequest reuse permissionsArticle Views580Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Asynchronous multiple-access channel capacity (1981)

The capacity region for the discrete memoryless multiple-access channel without time synchronization at the transmitters and receivers is shown to be the same as the known capacity region for the ordinary multiple-access channel. The proof utilizes time sharing of two optimal codes for the ordinary multiple-access channel and uses maximum likelihood decoding over shifts of the hypothesized transmitter words.