gebhart/patrepeval huggingface dataset:
COMPARISON OF CONVENTIONAL PYODINE DRESSING WITH HONEY DRESSING FOR THE TREATMENT OF DIABETIC FOOT ULCERS (2012)

Objective: To compare the conventional pyodine dressing with honey dressing in terms of recovery time and outcome (healed or ended up with amputation) in diabetic foot ulcers. Methodology: This quasi-experimental study was performed in surgical “C” ward, Lady Reading Hospital Peshawar from November 2007 to November 2008. All Wegner's grade I-IV, unilateral diabetic foot ulcer patients were admitted and their blood sugar profile, cardiac and renal status were investigated. Patients were assigned to group A and B with simple convenience method. After ample wound debridement group A and B were treated with daily conventional Pyodine dressing and Honey dressing respectively and their recovery time, outcome were recorded during the 10 weeks follow up period. Results: A total of 100 patients with 50 patients in each group A and B were enrolled in the study with mean age 56+8.0 years and male to female ratio of 1.7:1. Recovery time was significantly quicker in the Group B (Honey Dressing) as compared with the group A (conventional Pyodine dressing) with a p-valve of <0.0001. Healing rate was 69% and amputation rate was 31% as a whole. Healing rate was 66% in the Group A in comparison with 72% in the group B while amputation rates were 34% and 28% in the group A and B respectively with no statistical significance with a p-value of 0.6658. Conclusion: Honey dressing is more effective than conventional Pyodine dressing in terms of recovery time in the treatment of diabetic foot ulcer.
Voltammetric Determination of <scp>L</scp>‐Dopa on Poly(3,4‐ethylenedioxythiophene)‐Single‐Walled Carbon Nanotube Composite Modified Microelectrodes (2010)

Abstract In the present communication, it is shown that platinum microelectrodes electrochemically coated with a composite of poly(3,4‐)ethylenedioxythiophene and single‐walled carbon nanotubes (PEDOT/SWNT) enable determinations of 3,4‐dihydroxy‐ L ‐phenylalaines ( L ‐dopa) in neutral phosphate buffer solutions containing an excess of ascorbic acid. The interpenetrated networked nanostructure of the composite was characterized by scanning electron microscope (SEM) and Raman spectroscopy. It is shown that the presence of the composite gives rise to an increase in the electroactive area of an order of magnitude in compared to the area for the bare microelectrodes. The composite film‐coated microelectrode, which yielded reversible cyclic voltammograms for the ferro/ferricyanide redox couple for scan rates between 0.01 and 0.10 V s −1 , also gave rise to two well‐resolved oxidation peaks for L ‐dopa and ascorbic acid (AA). The latter effect, which was not seen in the absence of the composite, enabled differential pulse voltammetric determinations of L ‐dopa in the concentration range between 0.1 to 20 μM with a detection limit of 100 nM.
Multiparameter detection of apoptosis using red‐excitable SYTO probes (2008)

Functional assays allowing phenotypic characterization of different cell death parameters at a single-cell level are important tools for preclinical anticancer drug screening. Currently, the selection of cytometric assays is limited by the availability of fluorescent probes with overlapping spectral characteristics. Following on our earlier reports on green and orange fluorescent SYTO probes, we provide herein further insights into applicability of novel red-excitable SYTO stains (SYTO 17, 59-64) for multiparameter analysis of cell fate. In particular, SYTO 62 appears to be a spectrally favorable candidate. Using a correlative comparison between SYTO 16, Annexin V, YO-PRO 1, and fluorescently labeled inhibitors of caspases (FLICA), we demonstrate the specificity of SYTO 62 in detection of apoptotic cell death. Used in conjunction with FLICA or Annexin V, SYTO 62 stain proved amenable for multivariate kinetic analysis of apoptotic events. Considering simplicity of staining protocols, low cost, and avoidance of spectral compensation problems, we expect that red-excitable SYTO dyes will find a wide range of cytometric applications.
TPA-induced differentiation of rat aortic endothelial cells is substrate-specific and receptor mediated (1992)

Under normal conditions, the morphology of cultured endothelial cells (EC) is characterized by a contact-inhibited monolayer with a distinct cobblestone appearance. However, when treated with phorbol esters, EC acquire fibroblast-like growth characteristics, are no longer contact-inhibited in growth, become invasive and form pre-capillary, tubular structures within collagen matrices. These events describe the basic processes of angiogenesis. We characterized the early effects of phorbol-12-myristate-13-acetate (TPA) on the attachment and spreading of rat aortic endothelial cells (RAEC) to purified extracellular matrix proteins by analyzing the distribution of fibronectin integrin receptors and the organization of cytoskeleton microfilaments during RAEC spreading on four different extracellular matrix peptides (i.e., Collagen Types I and IV, fibronectin and laminin). Type IV collagen appeared to be the best substrate for RAEC adhesion and spreading while laminin proved to be the poorest. TPA (0.1 micron) decreased the rate of RAEC spreading on Type IV collagen with a subsequent delay in cell-cell contact formation. In contrast, TPA increases the rate of spreading and cell-cell contact formation of RAEC plated on laminin.
Detection of passage and absorption of chicken egg yolk immunoglobulins in the gastrointestinal tract of pigs by use of enzyme-linked immunosorbent assay and fluorescent antibody testing (1993)

Chicken egg yolk IgG can be absorbed and transferred as efficiently as colostral antibodies in the blood of neonatal pigs. Egg yolk IgG has a half-life of 1.85 days in newborn pig serum. This is shorter than the reported half-life (12 to 14 days) of homologous IgG in serum of pigs. Similar to colostral antibodies, egg yolk IgG absorption from intestine ceased at about 34 hours of age, after a logarithmic decrease in absorption rate from birth. Egg yolk IgG absorption inhibition time in the gastrointestinal tract took 1.73 hours to decrease by half. Egg yolk IgG was protective against experimentally induced diarrhea in pigs when it was administered at high dose, and multiple dosing was instituted. Adverse effects were not observed when chicken egg yolk IgG was administered orally to pigs.
Design and Implementation of Cognitive Wireless Network based on IEEE P1900.4 (2008)

IEEE P1900.4 is an emerging standard for optimized radio resource utilization where cognitive radio technologies are used for efficient spectrum utilization. In this paper, we design and implement a cognitive wireless network system based on open documents of IEEE P1900.4, and evaluate its performance using UDP streaming and HTTP download. Our experiments show interesting results that total network throughput in the HDP streaming is improved by 30% although some of individual terminals can not necessarily obtain better throughput. Also, it is shown that performance in the HTTP download becomes worse by up to about 40% as the number of handover increases due to the TCP window control. Our analysis is expected to point out importance of higher layer coordination with lower layers for end-to-end performance improvements in cognitive wireless networks.
An efficient diagnosis algorithm for inconsistent constraint sets (2011)

Abstract Constraint sets can become inconsistent in different contexts. For example, during a configuration session the set of customer requirements can become inconsistent with the configuration knowledge base. Another example is the engineering phase of a configuration knowledge base where the underlying constraints can become inconsistent with a set of test cases. In such situations we are in the need of techniques that support the identification of minimal sets of faulty constraints that have to be deleted in order to restore consistency. In this paper we introduce a divide and conquer-based diagnosis algorithm (F ast D iag ) that identifies minimal sets of faulty constraints in an overconstrained problem. This algorithm is specifically applicable in scenarios where the efficient identification of leading (preferred) diagnoses is crucial. We compare the performance of F ast D iag with the conflict-directed calculation of hitting sets and present an in-depth performance analysis that shows the advantages of our approach.
Cognitive impairment in mice over-expressing γ-aminobutyric acid transporter I (GAT1) (2003)

There is increasing evidence that GABAergic system plays an important role in the neural control of learning and memory processes. GAT1 over-expressing mice (NA) were generated, in which GAT1 is under the control of a neuron-specific enolase (NSE) promoter, to investigate effects of GABA transporter on cognitive function. Our results revealed that NA mice displayed cognitive deterioration in associative learning ability and new object recognition retention, compared with the wild-type littermates (WT2). However, the impaired cognitive function of transgenic mice could be rescued after chronic administration of GAT1 selective inhibitor for 6 days. In addition, there was no change of the expression of NMDA receptors in NA mice. Taken together, we show a potentially important role for GAT1 in the neural control of cognitive processes, and indicate great potential for GAT1 as a clinical target of cognitive disorders.
Yielding Behavior in Injectable Hydrogels from Telechelic Proteins (2010)

Injectable hydrogels show substantial promise for use in minimally invasive tissue engineering and drug delivery procedures.1,2 A new injectable hydrogel material, developed from recombinant telechelic proteins expressed in E. coli, demonstrates shear thinning by three orders of magnitude at large strains. Large amplitude oscillatory shear illustrates that shear thinning is due to yielding within the bulk of the gel, and the rheological response and flow profiles are consistent with a shear-banding mechanism for yielding. The sharp yielding transition and large magnitude of the apparent shear thinning allow gels to be injected through narrow gauge needles with only gentle hand pressure. After injection the gels reset to full elastic strength in seconds due to rapid reformation of the physical network junctions, allowing self-supporting structures to be formed. The shear thinning and recovery behavior is largely independent of the midblock length, enabling genetic engineering to be used to control the equilibrium modulus of the gel without loss of the characteristic yielding behavior. The shear-banding mechanism localizes deformation during flow into narrow regions of the gels, allowing more than 95% of seeded cells to survive the injection process.
Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice (1996)

PEG-rHuMGDF injected daily in normal mice causes a rapid dose-dependent increase in megakaryocytes and platelets. At the same time that platelet numbers are increased, the mean platelet volume (MPV) and platelet distribution width (PDW) can be either decreased, normal, or increased depending on the dose and time after administration. Thus, PEG-rHuMGDF at a low dose causes decreases in MPV and PDW, MGDF at an intermediate dose causes an initial increase followed by a decrease in MPV and PDW, and PEG-rHuMGDF at higher doses causes an increase in MPV and PDW followed by a gradual normalization of these platelet indices. In addition to the expected thrombocytosis after 7 to 10 days of daily injection of high doses of PEG-rHuMGDF, a transient decrease in peripheral red blood cell numbers and hemoglobin is noted accompanied in the bone marrow by megakaryocytic hyperplasia, myeloid hyperplasia, erythroid and lymphoid hypoplasia, and deposition of a fine network of reticulin fibers. Splenomegaly, an increase in splenic megakaryocytes, and extramedullary hematopoiesis accompany the hematologic changes in the peripheral blood and marrow to complete a spectrum of pathologic features similar to those reported in patients with myelofibrosis and megakaryocyte hyperplasia. However, all the PEG-rHuMGDF-initiated hematopathology including the increase in marrow reticulin is completely and rapidly reversible upon the cessation of administration of PEG-rHuMGDF. Thus, transient hyperplastic proliferation of megakaryocytes does not cause irreversible tissue injury. Furthermore, PEG-rHuMGDF completely ameliorates carboplatin-induced thrombocytopenia at a low-dose that does not cause the hematopathology associated with myelofibrosis.
Influence of Germination and Growing Temperature on Flowering of Six Cultivars of Annual Statice (Limonium cv.)1 (1973)

Abstract The influence of 3 germination temperature (16/13°, 21/18°, and 27/24°C day/night) and 2 growing temp (24/16° and 26/24°C day/night) on flowering in 6 cultivars of annual statice ( Limonium cv.) grown under long days was determined over a 24-week period. When grown at 24/16°C nearly all of the plants produced a visible flower stalk irrespective of the germination temp. Flowering percentages at 26/24°C varied greatly, depending upon the cultivar and the germination temp. When grown at a temp of 26/24°C, the percentage of ‘Blue Bonnet’ flowering was low regardless of the germination temp. However, the percentage of ‘Midnight Blue’, ‘Iceberg’, and ‘Twilight Lavender’ plants flowering at a growing temp of 26/24°C was higher following germ temp of 16/13° or 21/18°C. ‘Gold Coast’ flowered irrespective of temp treatment. Except for ‘Gold Coast’, plants grown at 24/16°C generally had the earliest and greatest number of mature flower stalks, and the highest flower stage. Thus, growing temp appears to be the chief determinant of flowering in annual statice.
Grain Growth in Nickel Ferrites (1958)

A discussion of continuous and discontinuous grain growth in nickel ferrites is presented. Experimental evidence indicates that the presence of polyphase material is favored by excess nickel oxide and that discontinuous grain growth can be accounted for by excess iron oxide. Quantitative measurements of isothermal grain‐growth rates in stoichiometric nickel ferrite yielded an energy of activation of 90 kcal. per mole for the process.
Purification, Characterization and Immuno-Modulating Properties of Polysaccharides Isolated from<i>Flammulina velutipes</i>Mycelium (2010)

To investigate the immuno-modulating activity of Flammulina velutipes mycelium, three different Flammulina velutipes polysaccharides (FVPs) were isolated by fractionation using gel filtration and were identified as the immunomodulators of murine peritoneal macrophages. Based on the results of fourier transform infrared spectroscopy (FTIR), high performance liquid chromatography (HPLC), NMR spectroscopy, methylation analysis and gas chromatography-mass spectrogram (GC-MS), FVP2C was identified as glucose, galactose, mannose and fucose in molar ratio of 100: 14: 7: 4. FVP2C, molecular weight of 27.3 x 10(3) Da, was characterized as alpha-D-(1-->4)-glucan which was highly branched with alpha-D-(1-->6)-glucosyl residues, a single galactose or small amounts of mannoses and fucose at the C-6 position every twelve residues, on average, along the main chain. In the present study, it was found that three FVPs induced a significant increase in cellular nitric oxide formation, interleukin-1 production and tumor necrosis factor-alpha secretion in macrophages in vitro. The immuno-modulating activity of FVP2A, FVP2B and FVP2C was dose-dependent.
Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin (2005)

Mutations in parkin are largely associated with autosomal recessive juvenile parkinsonism. The underlying mechanism of pathogenesis in parkin-associated Parkinson's disease (PD) is thought to be due to the loss of parkin's E3 ubiquitin ligase activity. A subset of missense and nonsense point mutations in parkin that span the entire gene and represent the numerous inheritance patterns that are associated with parkin-linked PD were investigated for their E3 ligase activity, localization and their ability to bind, ubiquitinate and effect the degradation of two substrates, synphilin-1 and aminoacyl-tRNA synthetase complex cofactor, p38. Parkin mutants vary in their intracellular localization, binding to substrates and enzymatic activity, yet they are ultimately deficient in their ability to degrade substrate. These results suggest that not all parkin mutations result in loss of parkin's E3 ligase activity, but they all appear to manifest as loss-of-function mutants due to defects in solubility, aggregation, enzymatic activity or targeting proteins to the proteasome for degradation.
Sex-Based Differences in Early Mortality after Myocardial Infarction (1999)

After myocardial infarction, younger women, but not older women, have higher rates of death during hospitalization than men of the same age. The younger the age of the patients, the higher the risk of death among women relative to men. Younger women with myocardial infarction represent a high-risk group deserving of special study.
VSEncoding (2010)

Encoding lists of integers efficiently is important for many applications in different fields. Adjacency lists of large graphs are usually encoded to save space and to improve decoding speed. Inverted indexes of Information Retrieval systems keep the lists of postings compressed in order to exploit the memory hierarchy. Secondary indexes of DBMSs are stored similarly to inverted indexes in IR systems. In this paper we propose Vector of Splits Encoding (VSEncoding), a novel class of encoders that work by optimally partitioning a list of integers into blocks which are efficiently compressed by using simple encoders. In previous works heuristics were applied during the partitioning step. Instead, we find the optimal solution by using a dynamic programming approach. Experiments show that our class of encoders outperform all the existing methods in literature by more than 10% (with the exception of Binary Interpolative Coding with which they, roughly, tie) still retaining a very fast decompression algorithm.
Two-tone optical heterodyne spectroscopy with a tunable lead-salt diode laser (1986)

We report the demonstration of two-tone optical heterodyne spectroscopy with a tunable lead-salt diode laser. Using high-frequency modulation of the diode-laser injection current, we demonstrated a detection-sensitivity limit of 1 x 10(-5) to differential absorption from Doppler-broadened NH(3) lines in the 930-cm(-1) region. In our experiment, this limit was set by preamplifier noise and the low quantum efficiency of the photodetector. A substantial increase in sensitivity should be possible by using an improved detector, an improved preamplifier, and higher optical power.
Liquid Bio-Fuel Production From Non-Food Biomass via High Temperature Steam Electrolysis (2011)

Two hybrid energy processes that enable production of synthetic liquid fuels that are compatible with the existing conventional liquid transportation fuels infrastructure are presented. Using biomass as a renewable carbon source, and supplemental hydrogen from high-temperature steam electrolysis (HTSE), these two hybrid energy processes have the potential to provide a significant alternative petroleum source that could reduce US dependence on imported oil. The first process discusses a hydropyrolysis unit with hydrogen addition from HTSE. The second process discusses a process named Bio-Syntrolysis. The Bio-Syntrolysis process combines hydrogen from HTSE with CO from an oxygen-blown biomass gasifier that yields syngas to be used as a feedstock for synthesis of liquid transportation fuels via a Fischer-Tropsch process. Conversion of syngas to liquid hydrocarbon fuels, using a biomass-based carbon source, expands the application of renewable energy beyond the grid to include transportation fuels. It can also contribute to grid stability associated with non-dispatchable power generation. The use of supplemental hydrogen from HTSE enables greater than 90% utilization of the biomass carbon content which is about 2.5 times higher than carbon utilization associated with traditional cellulosic ethanol production. If the electrical power source needed for HTSE is based on nuclear or renewable energy, the process is carbon neutral. INL has demonstrated improved biomass processing prior to gasification. Recyclable biomass in the form of crop residue or energy crops would serve as the feedstock for this process. A process model of syngas production using high temperature electrolysis and biomass gasification is presented. Process heat from the biomass gasifier is used to heat steam for the hydrogen production via the high temperature steam electrolysis process. Oxygen produced form the electrolysis process is used to control the oxidation rate in the oxygen-blown biomass gasifier.
Interleaved 3D‐<scp>CNN</scp>s for joint segmentation of small‐volume structures in head and neck<scp>CT</scp>images (2018)

An accurate and automatic segmentation method has been proposed for small tissues in head and neck CT images, which is important for the planning of radiotherapy.
New synthesis of 6[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid and evaluation of the influence of adamantyl group on the DNA binding of a naphthoic retinoid (2011)

6[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid (Adapalene®), a synthetic aromatic retinoid specific for RARβ and RARγ receptors, has been prepared utilizing a Pd/C-mediated Suzuki coupling between 6-bromo-2-naphthoic acid and 4-methoxyphenyl boronic acid, followed by introduction of an adamantyl group in the position 3 of the formed 6-(4-methoxyphenyl)-2-naphthoic acid. The interaction of 6-(4-methoxyphenyl)-2-naphthoic acid/ethyl ester and the 3-adamantyl analogs with DNA was studied in aqueous solution at physiological conditions by UV-vis spectroscopy. The calculated binding constants K(ligand-DNA) ranged between 1.1×10(4) M(-1) and 1.1×10(5) M(-1), the higher values corresponding to those of the adamantylated compounds. Molecular modeling studies have emphasized that the intercalative binding of adapalene and its derivatives to DNA is mainly stabilized by hydrophobic interactions related to the presence of the adamantyl group.