gebhart/patrepeval huggingface dataset:
Handling real-world motion planning: a hospital transport robot (1992)

A description is given of a hospital transport mobile robot, HelpMate, developed to carry out such tasks as the delivery of off-schedule meal trays, lab and pharmacy supplies, and patient records. Unlike many existing delivery systems in the industry which operate within a rigid network of wires buried or attached to the floor, a hospital transport robot is expected to be able to navigate much like a human would, including handling uncertainty and unexpected obstacles. The navigation system of HelpMate makes use of the specific structure of a hospital hallway environment and relies on recent results on provable sensor-based motion planning algorithms that specifically address the issue of navigation in an unknown and unstructured environment. Also incorporated in the system are algorithms for handling unmodeled factors such as sensor noise and sensor inaccuracy, errors in position estimation, and moving obstacles (e.g. people).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Heterogeneity of ERG expression in prostate cancer: a large section mapping study of entire prostatectomy specimens from 125 patients (2016)

These data show that about 20-30 % of prostate cancer foci have early ERG fusions. ERG fusions further occur in about 50 % of initially ERG negative cancer foci during cancer progression. The vast majority of cancers are heterogeneous for TMPRSS2:ERG fusions on a patient level, challenging the concept of classifying prostate cancer patients into "fusion type" and "non-fusion type" prostate cancer.
The sequence of 12.8 kb from the left arm of chromosome XIV reveals a sigma element, a pro-tRNA and six complete open reading frames, one of which encodes a protein similar to the human leukotriene A4 hydrolase. (1996)

We have determined the nucleotide sequence of a 12.8 kb fragment from the left arm of chromosome XIV carried by the cosmid 14-16d. An analysis of the sequence reveals the presence of a sigma element, a pro-tRNA gene and eight open reading frames, six of which are complete. All of the eight open reading frames correspond to new genes. Of the eight new genes, two show strong similarities to a pair of new genes from chromosome IX, suggesting an ancestral duplication, and one gene encodes a protein similar to mammalian leukotriene A4 hydrolase.
Estimating the trajectory of an accelerationless aircraft by means of a stationary acoustic sensor (1984)

The flight parameter of an aircraft moving without acceleration can be estimated by exploiting the target-generated noise received by a directional sensor consisting of three or four microphones. The Cramér–Rao lower bound is calculated to investigate the theoretical accuracy of estimates. Moreover, an algorithm is proposed which computes the maximum-likelihood estimate. Extended simulations prove the algorithm to work reliably and fast, and the estimate to be nearly unbiased and efficient when averaged over a large region of flight parameters. Results obtained with real data are included.
Seeing is believing: neuroimaging adds to our understanding of cerebral pathology (2006)

In-vivo imaging of cerebral pathology offers the potential for more effective and earlier diagnosis and use of these technologies as surrogate markers to test novel treatments aimed at preventing or eliminating cerebral plaque and tangle accumulation.
Effect of Surface Structure on Lubrication in Water of Hydrophilic/Hydrophobic Block Copolymer Coating Membrane. (1998)

親水性/疎水性ブロック共重合体 (ポリN,N'-ジメチルアクリルアミド-block-ポリグリシジルメタクリレート(PDMAA-b-PGMA)) を溶媒キャスト法にてポリウレタン基材にコートし, 乾燥温度を80～140°Cの範囲で作成した試料の表面構造と水中での潤滑特性について検討した。水に接触させる前のコーティング膜の最表面層には疎水性であるPGMAセグメントが濃縮されており, 乾燥温度が高いほどその傾向は顕著であった。乾燥温度の低い (80°Cおよび100°C) 試料を水に浸漬させると, コーティング膜の最表面層はPGMAセグメント rich からPDMAAセグメント rich と表面構造が変化し, 水中での動摩擦係数は0.03～0.04となった。水中での潤滑特性は乾燥温度が高くなると低下した。これは, 最表面層のPGMAセグメント濃縮度合いによって, 水に接触させた時の表面構造の変化が異なることに起因していることが分かった。親水性/疎水性ブロック共重合体コーティング膜が水と接触した時の表面構造の変化, 安定性が水中での潤滑特性に大きく影響することが明らかとなった。
Active Control of Buzz-saw Tones: Experimental Results from a Laboratory-scale Rig (2005)

This paper details the results of an experiment on a small scale no-flow rig to control a spinning mode with similar characteristics to the modes generated by buzz-saw noise. The spinning mode (<i>m</i> = -3, <i>n</i> = 1) is generate by a mode synthesiser ring which has similar characteristics to that of a low frequency Buzz-saw mode. A control system using seven microphones an seven control actuators is used to minimise the sum of the squared pressure at the duct wall using a Filtered reference Least Mean Squares (FXLMS algorithm). It is shown that at certain frequencies the sound power transmitted to the duct termination is reduced by 14.5dB. The control mechanism at different frequency ranges are identified and discussed with reference to computer simulations. It is shown that cut-off modes excited by the secondary actuator array have a significant effect on control performance a frequencies close to the cut-on frequency of the (<i>m</i> = -4, <i>n</i> = 1) mode.
Introduction: from Workes to Texts (1999)

The essays collected in this volume were all (with one exception) first presented as papers at a conference at the University of Leeds in July 1995, the central objective of which was to consider the effects of the way that Ben Jonson's texts have been edited on the condition of Jonson studies at the present time.1 The particular question that participants were invited to address was the status of the Oxford Ben Jonson, edited by C. H. Herford, Percy Simpson and Evelyn Simpson (11 vols, 1925–52), and the degree to which this edition can retain its usefulness in the future. As the standard scholarly text, the Oxford edition is the necessary point of reference for all work on Jonson. It is, though, increasingly apparent that its value has gradually diminished as the overall state of knowledge about Jonson's time has increased, and as the cultural and pedagogical climate within which he is read has altered.
Pharmacologic approaches to cognitive deficits in Alzheimer's disease. (1998)

This article reviews placebo-controlled studies addressing drug efficacy for the cognitive deficits of Alzheimer's disease. Efforts to compensate for the presynaptic cholinergic deficiency in Alzheimer's disease by pharmacologically inhibiting acetylcholine degradation have been successful in several clinical trials. Two cholinesterase inhibitors are available for Alzheimer's disease, and others most likely will soon be available. Cholinesterase inhibitors represent the only therapy currently approved for the treatment of Alzheimer's disease. The antioxidant drugs alpha-tocopherol (vitamin E) and selegiline have been demonstrated marginally superior to placebo for slowing functional deterioration in patients with moderately advanced Alzheimer's disease. Epidemiologic studies suggest protective effects against Alzheimer's disease from postmenopausal estrogen replacement and nonsteroidal anti-inflammatory drugs. Placebo-controlled studies prospectively evaluating the hypotheses generated by these epidemiologic studies are ongoing.
Principal Component Analysis of Skin Color and Its Application to Colorimetric Color Reproduction on CRT Display and Hardcopy (1996)

We propose a new method to predict the images on a CRT and a hardcopy of skin color under various illuminants. Spectral reflectance of human skin is analyzed by principal component analysis and it is shown that the spectral reflectance can be estimated by three basis functions. The estimation allows colorimetric color reproduction without colorimetric measurements for each illuminant. The proposed method is verified by several skin color patches taken by a calibrated HDTV camera. The method is also applied to practical facial pattern images.
Compensation of Strong Thermal Lensing in High-Optical-Power Cavities (2006)

In an experiment to simulate the conditions in high optical power advanced gravitational wave detectors, we show for the first time that the time evolution of strong thermal lenses follows the predicted infinite sum of exponentials (approximated by a double exponential), and that such lenses can be compensated using an intracavity compensation plate heated on its cylindrical surface. We show that high finesse approximately 1400 can be achieved in cavities with internal compensation plates, and that mode matching can be maintained. The experiment achieves a wave front distortion similar to that expected for the input test mass substrate in the Advanced Laser Interferometer Gravitational Wave Observatory, and shows that thermal compensation schemes are viable. It is also shown that the measurements allow a direct measurement of substrate optical absorption in the test mass and the compensation plate.
Supervised Link Prediction Using Multiple Sources (2010)

Link prediction is a fundamental problem in social network analysis and modern-day commercial applications such as Face book and My space. Most existing research approaches this problem by exploring the topological structure of a social network using only one source of information. However, in many application domains, in addition to the social network of interest, there are a number of auxiliary social networks and/or derived proximity networks available. The contribution of the paper is twofold: (1) a supervised learning framework that can effectively and efficiently learn the dynamics of social networks in the presence of auxiliary networks, (2) a feature design scheme for constructing a rich variety of path-based features using multiple sources, and an effective feature selection strategy based on structured sparsity. Extensive experiments on three real-world collaboration networks show that our model can effectively learn to predict new links using multiple sources, yielding higher prediction accuracy than unsupervised and single-source supervised models.
Neuroglobin attenuates β-amyloid neurotoxicity <i>in vitro</i> and transgenic Alzheimer phenotype <i>in vivo</i> (2007)

Neuroglobin (Ngb), a vertebrate globin expressed primarily in neurons, is induced by and protects against neuronal hypoxia and cerebral ischemia. To investigate the spectrum and mechanism of Ngb's neuroprotective action, we studied the effect of transgenic overexpression of Ngb on NMDA and beta-amyloid (Abeta) toxicity in murine cortical neuron cultures in vitro and on the phenotype of Alzheimer's disease (AD) transgenic (APP(Sw,Ind)) mice. Compared with cortical neuron cultures from wild-type mice, cultures from Ngb-overexpressing transgenic (Ngb-Tg mice) were resistant to the toxic effects of NMDA and Abeta(25-35), as measured by polarization of cell membrane lipid rafts, mitochondrial aggregation, lactate dehydrogenase release, and nuclear fragmentation. In addition, compared with APP(Sw,Ind) mice, double-transgenic (Ngb-Tg x APP(Sw,Ind)) mice showed reductions in thioflavin-S-stained extracellular Abeta deposits, decreased levels of Abeta(1-40) and Abeta(1-42), and improved behavioral performance in a Y-maze test of spontaneous alternations. These findings suggest that the spectrum of Ngb's neuroprotective action extends beyond hypoxic-ischemic insults. Ngb may protect neurons from NMDA and Abeta toxicity by inhibiting the formation of a death-signaling membrane complex, and interventions that increase Ngb expression could have therapeutic application in AD and other neurodegenerative disorders.
The Effects of the Edinburgh Masker on Stuttering (1996)

Auditory feedback masking has long been thought to be a clinically useful procedure for the modification of stuttered speech in adults, and the Edinburgh Masker is a commercial device for providing such masking. In the present study, 18 subjects spoke under various masking and nonmasking conditions using the Edinburgh Masker, both in and beyond the clinic. Results showed that stuttering rate reduced by a mean of around 50% in masking compared to nonmasking conditions. Only one subject completely eliminated stuttering, and did so in only one of many speaking tasks. Listeners judged masked speech to be less natural sounding than nonmasked speech. It is concluded that, for some clients, there may be some benefit in masked speech by means of the Edinburgh Masker, but that the device does not appear to produce either stutter-free or natural sounding speech.
Dynamic Inverted Index Maintenance (2007)

The majority of today's IR systems base the IR task on two main processes: indexing and searching. There exists a special group of dynamic IR systems where both processes (indexing and searching) happen simultaneously; such a system discards obsolete information, simultaneously dealing with the insertion of new in¬formation, while still answering user queries. In these dynamic, time critical text document databases, it is often important to modify index structures quickly, as documents arrive. This paper presents a method for dynamization which may be used for this task. Experimental results show that the dynamization process is possible and that it guarantees the response time for the query operation and index actualization.
Socioeconomic status and obesity: A review of the literature. (1989)

A review of 144 published studies of the relationship between socioeconomic status (SES) and obesity reveals a strong inverse relationship among women in developed societies. The relationship is inconsistent for men and children in developed societies. In developing societies, however, a strong direct relationship exists between SES and obesity among men, women, and children. A review of social attitudes toward obesity and thinness reveals values congruent with the distribution of obesity by SES in different societies. Several variables may mediate the influence of attitudes toward obesity and thinness among women in developed societies that result in the inverse relationship between SES and obesity. They include dietary restraint, physical activity, social mobility, and inheritance.
An inverse method for determining transient temperature distribution in glass plates (1995)

Experimental measurements of the transient internal temperature distributions in 2.26, 3.71 and 6.76 mm thick glass plates using thermocouples fused in the glass and by the spectral remote sensing (SRS) method have been carried out. Experimentally measured and reconstructed temperatures are compared to predictons based on the solution of the transient energy equation where the internal radiative transfer has been accounted for using rigorous radiative transfer theory. A discussion of the experimental method to determine the temperatures, and the validation of the energy model and of the SRS method is included. The measurements were made as the test plates cooled, from an initial temperature of approximately 520 °C, by radiation and natural convection in the laboratory ambient. Temperatures determined by the SRS method are compared with those from thermocouples fused in the glass and with theoretical predictions to demonstrate the accuracy and limitations of the SRS method. The agreement between the SRS method, thermocouple measurements, and theoretical predictions show that the SRS method can be used to determine the front, center and back temperatures to within approximately ± 0.5%, ± 1.0% and ± 5.0%, respectively, for a 3.71 mm thick glass plate when intensity of radiation emerging from the plate is measured from one side.
The compressive properties of single osteons (1968)

Abstract The compressive strength of single human osteons has been investigated in specially prepared samples using a microtesting machine equipped with a microwave micrometer. The main conclusions which can be drawn from our results are: (1) In agreement with Gebhardt's theories the ultimate compressive strength is greatest for osteons having transversally oriented fiber bundles, lowest for osteons having longitudinally oriented fiber bundles, and intermediate for osteons whose fiber bundles change direction in successive lamellae through an angle of about 90°. (2) The modulus of elasticity is greatest in osteons with transversally oriented fiber bundles. (3) With all three types of osteon the stress‐strain curves for fully calcified osteons are markedly different from those for osteons with low calcium content, the modulus of elasticity being much lower in osteons of the latter type. (4) Age seems to have no measurable influence on the compressive properties of osteons. (5) The comparison of compressive properties in single osteons and in macroscopic bone samples seems to support the view that the osteon is actually the mechanical unit of compact bone. (6) Fracture in osteon samples starts with microscopic fissures induced by shearing. (7) In every case these fissures form an angle of roughly 30°–35° with the axis of the osteon and do not appear to vary with the microscopic osteon structures. (8) Electron microscopy reveals distortion of bone crystals and breaking of collagen fibrils at the edges of the fissures.
Speckle Generation by Phase-Only Spatial Modulators: Random Phase Properties That Produce Fully Complex Modulation and that Model Optical Processor Performance. (1996)

Abstract : Optoelectronic processors that use phase only and amplitude phase coupled spatial light modulators (SLMs) can be profoundly affected by phase errors. These errors arise not only from irregularities in the modulators themselves, but at a number of points along the signal processing chain. Traditional theories of speckle generation by rough surface scattering are adapted to analyzing SLMs. SLMs are modeled as arrays of subapertures/pixels that are perturbed by random phase components (constant and linear retardations). The effects of not only random, but also systematic. phase errors on the performance of diffractive optical elements (DOEs) and optical correlators are evaluated. While traditional speckle theory models random surfaces as stationary random processes, SLMs can be programmed to produce nonstationary optical surfaces. This generalization is used to devise a new class of computer generated holographic algorithms, referred to as pseudorandom encoding. The method is notable in that it: (1) uses all available space bandwidth of the SLM; (2) produces diffraction patterns having large signal to noise ratio; and, most notably, (3) can be calculated in real time by serial processors. Simulations and experimental demonstrations using SLMs are presented, and applications to pattern recognition, optical interconnects, multispot beam steering, and acceleration of DOE design algorithms are described.
<i>Pseudomonas aeruginosa</i>Virulence Analyzed in a<i>Dictyostelium discoideum</i>Host System (2002)

Pseudomonas aeruginosa is an important opportunistic pathogen that produces a variety of cell-associated and secreted virulence factors. P. aeruginosa infections are difficult to treat effectively because of the rapid emergence of antibiotic-resistant strains. In this study, we analyzed whether the amoeba Dictyostelium discoideum can be used as a simple model system to analyze the virulence of P. aeruginosa strains. The virulent wild-type strain PAO1 was shown to inhibit growth of D. discoideum. Isogenic mutants deficient in the las quorum-sensing system were almost as inhibitory as the wild type, while rhl quorum-sensing mutants permitted growth of Dictyostelium cells. Therefore, in this model system, factors controlled by the rhl quorum-sensing system were found to play a central role. Among these, rhamnolipids secreted by the wild-type strain PAO1 could induce fast lysis of D. discoideum cells. By using this simple model system, we predicted that certain antibiotic-resistant mutants of P. aeruginosa should show reduced virulence. This result was confirmed in a rat model of acute pneumonia. Thus, D. discoideum could be used as a simple nonmammalian host system to assess pathogenicity of P. aeruginosa.
dl-BETA-PHENYLISOPROPYLAMINES (1932)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTdl-BETA-PHENYLISOPROPYLAMINESGordon A. AllesCite this: J. Am. Chem. Soc. 1932, 54, 1, 271–274Publication Date (Print):January 1, 1932Publication History Published online1 May 2002Published inissue 1 January 1932https://pubs.acs.org/doi/10.1021/ja01340a040https://doi.org/10.1021/ja01340a040research-articleACS PublicationsRequest reuse permissionsArticle Views370Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
State-of-the-art Piezoelectric Transformer technology (2007)

To date, piezoelectric transformers (PTs) have been extensively commercialised in step-up applications, such as cold cathode fluorescent lamp backlighting for LCDs. As step-down PT technology matures, PT-based converters are set to replace conventional transformers and power converters in a wide variety of applications that require relatively low power levels, low cost, high efficiency, high power density, small size and weight, low EMI, and high reliability. This paper examines the various types of piezoelectric transformer and provides an overview of the materials technology, converter designs, and control methods involved with their use.
Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ (2015)

Idelalisib (also known as GS-1101, CAL-101, IC489666, and Zydelig) is a PI3Kδ inhibitor that has recently been approved for the treatment of several hematological malignancies. Given its use in human diseases, we needed a clear picture of how idelalisib binds to and inhibits PI3Kδ. Our data show that idelalisib is a potent and selective inhibitor of the kinase activity of PI3Kδ. A kinetic characterization clearly demonstrated ATP-competitive inhibition, and several additional biochemical and biophysical assays showed that the compound binds reversibly and noncovalently to the kinase. A crystal structure of idelalisib bound to the p110δ subunit of PI3Kδ furthers our understanding of the binding interactions that confer the potency and selectivity of idelalisib.
Robust Passive LED Driver Compatible With Conventional Rapid-Start Ballast (2011)

In this paper, a new LED fluorescent driver compatible with a rapid-start ballast is proposed. Using a compensation circuit composed of passive elements, a new LED fluorescent driver having highly reliable and robust characteristics was developed. This driver can prevent the fire problem that arose in conventional LED fluorescent switching power supplies. The design principle and architecture of the proposed LED driver was explained, and its feasibility was confirmed by simulations and experiments.