gebhart/patrepeval huggingface dataset:
Ureasil Gels as a Highly Efficient Adsorbent for Water Purification (2006)

Ureasils are nanocomposite organic−inorganic materials based on a silica backbone covalently connected through urea bridges with poly(oxyalkylene) chains. Ureasil gels are synthesized by the sol−gel procedure. These gels can efficiently adsorb and retain dyes from aqueous solutions and, thus, can be employed as water purification agents. Anionic dyes bearing a sulfonate chemical group are most efficiently adsorbed, followed by hydrophobic dyes and, finally, by cationic dyes. The adsorption of anionic dyes is very impressive, because a densely colored water sample is transformed into crystal clear water by using only a small quantity of ureasil adsorbent. Variations of the adsorption efficiency have been detected by varying the poly(oxyalkylene) chain length or by using different catalysts of the sol−gel procedure. The most efficient adsorbents were gels made by the conventional sol−gel route, that is, by HCl catalysis.
The Effects of Stress on the Immunology of the Stocker Calf (1985)

Many stressors contributing to bronchopneumonia have been identified and reported. Of all these stressors, transportation seems to have the most detrimental effect on the animal. Serum cortisol concentrations are often used as a measure of stress. Trucking of calves resulted in a significant (P<.05) increase in cortisol levels while weaning produced only a small increase. Another effect of transportation stress is excessive shrink. Studies conducted at this laboratory indicate that cattle that are transported shrink more than cattle that are deprived of feed and water for the same amount of time. Trucking and stress in general also have profound effects not only on the total numbers and percentages of white blood cells, but on their functional capabilities as well.
Directed Evolution of Enzymes (1998)

On the way to a combinatorial biotechnology? The directed evolution of enzymes promises a rapid access to effective biocatalysts. New molecular biology techniques for random mutagenesis in combination with high-throughput screening might revolutionize the creation of enzymes with new and improved properties.
LTCC technology for 40GHz bandpass waveguide filter (2005)

This paper reports on a surface mountable 41.5GHz waveguide narrow band-pass filter with a -3dB bandwidth of 7.2%, realized in LTCC (low-temperature cofired ceramics) technology. This filter is designed and optimized by 3D electromagnetic simulations taking into account CPW accesses. It has been built and presents great experimental performances, with insertion losses lower than 1.6dB. This filter is consistent with a planar integration.
synergistic Coordination in Ternary Complexes of Eu3+ with Aromatic .beta.-Diketone Ligands and 1,10-Phenanthroline (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTsynergistic Coordination in Ternary Complexes of Eu3+ with Aromatic .beta.-Diketone Ligands and 1,10-PhenanthrolineSteven T. Frey, Meng Lian Gong, and William D. Horrocks Jr.Cite this: Inorg. Chem. 1994, 33, 15, 3229–3234Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ic00093a006https://doi.org/10.1021/ic00093a006research-articleACS PublicationsRequest reuse permissionsArticle Views610Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Early Motor Dysfunction and Striosomal Distribution of Huntingtin Microaggregates in Huntington's Disease Knock-In Mice (2002)

Huntington's disease (HD) is characterized by a progressive loss of neurons in the striatum and cerebral cortex and is caused by a CAG repeat expansion in the gene encoding huntingtin. Mice with the mutation inserted into their own huntingtin gene (knock-in mice) are, genetically, the best models of the human disease. Here we show for the first time that knock-in mice with 94 CAG repeats develop a robust and early motor phenotype at 2 months of age, characterized by increased rearing at night. This initial increase in repetitive movements was followed by decreased locomotion at 4 and 6 months, despite a normal life span. The decrease in striatal enkephalin mRNA that is known to occur at 4 months was not present at 2 months, when increased rearing was observed. Both the hyperactive and hypoactive phases of motor dysfunction preceded the detection of nuclear microaggregates of mutated huntingtin in striatal neurons. Nuclear microaggregates, defined as small huntingtin-positive punctas detected by light microscopy, were very rare at 4 months but became widely distributed in striatal neurons at 6 months. Nuclear inclusions did not appear until 18 months. When present, nuclear microaggregates predominated in the striosomal compartment of the striatum, providing a possible explanation for the different neuronal vulnerability of striatal compartments observed in humans. The early motor phenotype observed in the knock-in mouse is reminiscent of repetitive movements often observed in early HD and provides a novel opportunity to assess the ability of therapies to prevent the initial effects of the mutation in vivo.
Simulation and Experimental Research on Cutting Force of Turning Titanium Alloy (2015)

This paper mainly establishes a two-dimensional model about the YG8 carbide tool turning TC4 titanium alloy on the basis of ABAQUS. The cutting force of the simulation model was verified by the turning experiment, and the relationships of cutting force with cutting speed, feed rate and rake angle of cutting edge in the model were studied. A prediction model of main cutting force related to cutting speed, feed rate and rake angle was obtained by central composite experiment. Studies have shown that the difference between the cutting force acquired by simulation and by experiment was less than 10%; in a certain range, the cutting force increased with the feed rate, the cutting force decreased with the increase of cutting speed and rake angle, and the influence of feed rate to cutting force was most significant.
Identification of novel microRNA targets based on microRNA signatures in bladder cancer (2009)

MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate protein-coding genes. To identify miRNAs that have a tumor suppressive function in bladder cancer (BC), 156 miRNAs were screened in 14 BCs, 5 normal bladder epithelium (NBE) samples and 3 BC cell lines. We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs. To confirm these results, 104 BCs and 31 NBEs were subjected to real-time RT-PCR-based experiments, and the expression levels of each miRNA were significantly downregulated in BCs (p < 0.0001 in all). Receiver-operating characteristic curve analysis revealed that the expression levels of these miRNAs had good sensitivity (>70%) and specificity (>75%) to distinguish BC from NBE. Our target search algorithm and gene-expression profiling in BCs (Kawakami et al., Oncol Rep 2006;16:521-31) revealed that Keratin7 (KRT7) mRNA was a common target of the downregulated miRNAs, and the mRNA expression levels of KRT7 were significantly higher in BCs than in NBEs (p = 0.0004). Spearman rank correlation analysis revealed significant inverse correlations between KRT7 mRNA expression and each downregulated miRNA (p < 0.0001 in all). Gain-of-function analysis revealed that KRT7 mRNA was significantly reduced by transfection of 3 miRNAs (miR-30-3p, miR-133a and miR-199a*) in the BC cell line (KK47). In addition, significant decreases in cell growth were observed after transfection of 3 miRNAs and si-KRT7 in KK47, suggesting that miR-30-3p, miR-133a and miR-199a* may have a tumor suppressive function through the mechanism underlying transcriptional repression of KRT7.
Model‐based pre‐processing in Raman spectroscopy of biological samples (2016)

Model‐based pre‐processing has become wide spread in spectroscopy and is the standard procedure in Fourier‐transform infrared spectroscopy. It has also been shown to give valuable contributions in Raman spectroscopy. Extended multiplicative signal correction is flexible enough to handle varying fluorescence background and take into account individual variations in baselines while still keeping enough rigidity through reference spectra and model fitting to avoid degenerate solutions and overfitting, when used correctly. We demonstrate the basic extended multiplicative signal correction method and some extensions, including a novel shift correction, on real Raman data to demonstrate effects on visual appearance, replicate variation and prediction. Comparisons with other standard correction methods are also shown and discussed. © 2016 The Authors. Journal of Raman Spectroscopy Published by John Wiley & Sons, Ltd.
In vivo and in vitro pressor effects of erythropoietin in rats (1995)

Hypertension (HTN) is a common complication of recombinant erythropoietin (EPO) therapy, but the mechanism of the EPO-associated HTN is uncertain. In the present study we examined the effects of EPO and the vehicle alone on rat caudal artery contractile response and basal and thrombin-stimulated platelet cytosolic Ca2+ concentration ([Ca2+]i) in vitro and on blood pressure (BP) and heart rate in vivo. At high concentrations (200 U/ml) EPO caused a small but consistent contraction in the caudal artery rings (P < 0.01) without affecting the response to either angiotensin II (ANG II) or the alpha 1-agonist methoxamine. Incubation with EPO significantly increased basal platelet [Ca2+]i (P < 0.01) and augmented the thrombin-induced rise of [Ca2+]i in Ca(2+)-free medium (P < 0.05). Long-term EPO administration led to a significant elevation of BP within 2 wk regardless of whether the hematocrit was allowed to rise or was kept constant by dietary iron deficiency. In contrast, single intravenous administration of high-dose EPO (400 and 5,000 U/kg), estimated to yield plasma concentrations comparable with those employed in vitro, failed to either alter BP or modify the BP response to ANG II during a 60-min observation period. This was associated with a significant rise in plasma guanosine 3',5'-cyclic monophosphate but no discernible change in plasma atrial natriuretic peptide, suggesting enhanced nitric oxide (NO) release. Thus, at high concentrations, EPO appears to possess a fast-acting pressor effect in vitro but not in vivo. The observed discrepancy may be due to enhanced NO release with EPO administration in vivo. However, HTN does occur with repeated EPO administration in a time-dependent and hematocrit-independent manner. This suggest that expression of the hypertensive effect of EPO in vivo involves a gradual conditioning process.
Computational Physics (2018)

Computational Physics is designed to provide direct experience in the computer modeling of physical systems. Its scope includes the essential numerical techniques needed to "do physics" on a computer. Each of these is developed heuristically in the text, with the aid of simple mathematical illustrations. However, the real value of the book is in the eight Examples and Projects, where the reader is guided in applying these techniques to substantial problems in classical, quantum, or statistical mechanics. These problems have been chosen to enrich the standard physics curriculum at the advanced undergraduate or beginning graduate level. The book will also be useful to physicists, engineers, and chemists interested in computer modeling and numerical techniques. Although the user-friendly and fully documented programs are written in FORTRAN, a casual familiarity with any other high-level language, such as BASIC, PASCAL, or C, is sufficient. The codes in BASIC and FORTRAN are available on the web at https://www.computationalphysics.info. They are available in zip format, which can be expanded on UNIX, Window, and Mac systems with the proper software. The codes are suitable for use (with minor changes) on any machine with a FORTRAN-77 compatible compiler or BASIC compiler. The FORTRAN graphics codes are available as well. However, as they were originally written to run on the VAX, major modifications must be made to make them run on other machines.
Pose-aware Multi-level Feature Network for Human Object Interaction Detection (2019)

Reasoning human object interactions is a core problem in human-centric scene understanding and detecting such relations poses a unique challenge to vision systems due to large variations in human-object configurations, multiple co-occurring relation instances and subtle visual difference between relation categories. To address those challenges, we propose a multi-level relation detection strategy that utilizes human pose cues to capture global spatial configurations of relations and as an attention mechanism to dynamically zoom into relevant regions at human part level. Specifically, we develop a multi-branch deep network to learn a pose-augmented relation representation at three semantic levels, incorporating interaction context, object features and detailed semantic part cues. As a result, our approach is capable of generating robust predictions on fine-grained human object interactions with interpretable outputs. Extensive experimental evaluations on public benchmarks show that our model outperforms prior methods by a considerable margin, demonstrating its efficacy in handling complex scenes.
Parametric modeling and control of a long-range actuator using magnetic servo levitation (1998)

A mechatronic device based on magnetic servo levitation (MSL) is proposed for long range and wide bandwidth actuation. The force capability of this type of actuator can be significantly larger than a linear motor or voice-coil actuator of similar dimensions. A novel parametric model of the electromagneto-mechanical coupled system has been developed to describe its behavior over a large range of motion and frequency, as opposed to more conventional attractive force small-perturbation models. It also provides a convenient way of devising a feedback linearizing control scheme that eliminates the need for high biasing currents present in most magnetic bearing systems. This paper presents a feedback-linearized controller coupled with a Kalman filter as a first approach to solve the tracking problem for such an actuator. Good tracking performance have been found both in simulation and experiments.
Erratum: “AlN/GaN and (Al,Ga)N/AlN/GaN two-dimensional electron gas structures grown by plasma-assisted molecular-beam epitaxy” [J. Appl. Phys. <b>90</b>, 5196 (2001)] (2002)

First Page
Two‐dimensional <sup>1</sup>H‐NMR studies of phospholipase‐A<sub>2</sub>‐inhibitor complexes bound to a micellar lipid‐water interface (1991)

One- and two-dimensional NMR studies were performed on the complexes of porcine pancreatic phospholipase A2 with substrate analogs bound to a micellar lipid-water interface of fully deuterated dodecylphosphocholine. The interactions between the inhibitor and the enzyme were localized by comparison of the two-dimensional NOE spectra recorded for the enzyme-inhibitor complex using both protonated and selectively deuterated inhibitors. These experiments led us to the following conclusions for the phospholipase-A2-micelle complex: (i) the 38-kDa phospholipase A2 complex gives NMR spectra with relatively narrow lines, which is indicative of high mobility of the enzyme; (ii) the residues Ala1, Trp3, Phe63 and Tyr69 located in the interface recognition site, as well as Phe22, Tyr75, Phe106 and Tyr111 are involved in the micelle-binding process; (iii) when present on the micelle, phospholipase A2 is stereospecific for the inhibitor binding; (iv) the inhibitor, (R)-dodecyl-2-aminohexanol-1-phosphoglycol, binds stoichiometrically to phospholipase A2 with high affinity (Kd less than or equal to 10 microM); (v) the inhibitor binds in the active site of the enzyme, which is evidenced by large chemical-shift differences for Phe5, Ile9, Phe22, His48, Tyr52 and Phe106; (vi) the acyl chain of the inhibitor makes hydrophobic contacts (less than 0.4 nm) near Phe5, Ile9, Phe22 and Phe106. Comparison of our results on the enzyme-inhibitor-micelle ternary complex with the crystal structure of the enzyme-inhibitor complex [Thunnissen, M. M. G. M., AB, E., Kalk, K. H., Drenth, J., Dijkstra, B. W., Kuipers, O. P., Dijkman, R., de Haas, G. H. & Verheij, H. M. (1990) Nature 347, 689-691] shows that the mode of inhibitor binding is similar.
Efficacy of anticoagulation post-inferior vena caval filter placement. (1998)

Anticoagulation with heparin or Coumadin is usually effective in the management of deep vein thrombosis; however, if anticoagulation treatment is contraindicated, is ineffective, or leads to adverse effects, inferior vena caval (IVC) placement of a filter is indicated. The purpose of this study is to determine whether increased early adverse effects are present in patients not given anticoagulation medication after placement of an IVC filter. The records of 240 consecutive patients who received IVC filter placement were reviewed for indications for placement, as well as for whether patients received anticoagulation medication on discharge. There were 41 in-patient mortalities. Of the remaining 199 patients, 100 were discharged and prescribed anticoagulation medication, and 99 were not. Patients were followed for 3 to 60 months. These results suggest that no early adverse effects are seen in patients who are not given anticoagulants after IVC filter placement.
Computer Aided Design of Experiments (1969)

A computer oriented method which assists in the construction of response surface type experimental plans is described. It takes into account constraints met in practice that standard procedures do not consider explicitly. The method is a sequential one and each step covers the experimental region uniformly. Applications to well-known situations are given to demonstrate the reasonableness of the procedure. Application to a ‘messy” design situation is given to demonstrate its novelty.
Dan Gookin Teaches Windows 98 (1998)

From the Publisher:
Dan Gookin covers all the fundamentals of Windows 98 in a book designed for beginners. In Dan Gookin's words, The key to making the beginner happy is knowing where to cut the rope and let them run or let them go. This book offers as much of an introduction into various areas of Windows to get people going, but not to bore them to death. Each chapter is self-contained and moderate in length. Chapters are heavily include call-outs that explain or point-out various parts of the screen. Icons and margin illustrations are used throughout the text.
Chromatic dispersion control in photonic crystal fibers: application to ultra-flattened dispersion (2003)

In order to control dispersion and dispersion slope of indexguiding photonic crystal fibers (PCFs), a new controlling technique of chromatic dispersion in PCF is reported. Moreover, our technique is applied to design PCF with both ultra-low dispersion and ultra-flattened dispersion in wide wavelength range. A full-vector finite element method with anisotropic perfectly matched layers is used to analyze the dispersion properties and the confinement losses in a PCF with finite number of air holes. It is shown from numerical results that it is possible to design a fourring PCF with flattened dispersion of 0 +/- 0.5 ps/(km.nm) from 1.19 m to 1.69 m wavelength range and a five-ring PCF with flattened dispersion of 0 +/- 0.4 ps/(km.nm) from 1.23 m to 1.72 m wavelength range.
The Natural History of Infection with Hepatitis C Virus (HCV) in Chimpanzees: Comparison of Serologic Responses Measured with First- and Second- Generation Assays and Relationship to HCV Viremia (1992)

The sensitivity of first- and second-generation tests for antibody to hepatitis C virus (HCV) and the relationship among the patterns of antibody response and HCV viremia were examined in serial serum samples from 6 chimpanzees experimentally infected with HCV and followed less than or equal to 3 years. HCV infection was transient in 4 chimpanzees and became chronic in 2. All chimpanzees developed antibodies to HCV detectable by second-generation assays, while only 5 of the 6 became positive by first-generation assay. Second-generation were consistently more sensitive than first-generation assays for the early diagnosis of primary HCV infection. The pattern observed with second-generation assays was not influenced by the outcome of HCV infection, since antibodies remained persistently detectable throughout follow-up regardless of whether viremia was transient or persistent. In contrast, the first-generation antibody response was variable: It usually disappeared after loss of viremia, whereas its presence paralleled HCV viremia in chimpanzees with chronic infection.
Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys (2011)

SMIP 2LM20-4, which binds to a fraction of CD20 molecules as compared with rituximab, has more potent in vitro CDC, and more potent and sustained B-cell depletion activity in cynomolgus monkeys. Our work has considerable clinical relevance since it provides novel insights related to the emerging B-cell depletion therapies in autoimmune diseases.
L<sub>g</sub> = 25 nm InGaAs/InAlAs high-electron mobility transistors with both f<sub>T</sub> and f<sub>max</sub> in excess of 700 GHz (2019)

Abstract In this paper, we report an L g = 25 nm InGaAs/InAlAs HEMT on InP substrate that delivers excellent high-frequency characteristics. The device exhibited a value of maximum transconductance ( g m_max ) = 2.8 mS μ m −1 at V DS = 0.8 V and on-resistance ( R ON ) = 279 Ω μ m. At I D = 0.56 mA μ m −1 and V DS = 0.5 V, the same device displayed an excellent combination of f T = 703 GHz and f max = 820 GHz. To the best of the authors’ knowledge, this is the first demonstration of a transistor with both f T and f max over 700 GHz on any material system.
Signal estimation using modified Wigner distributions (2005)

The Short-time Fourier transform(STFT), the Ambiguity Function(AF), and the Wigner distribution (WD) are mixed time-frequency signal representations that use Fourier transform techniques to map a one-dimensional function of time into a two-dimensional function of time and frequency. These mixed time-frequency mappings have been used to analyze the local frequency characteristics of a variety of signals and systems. Although much work has also been done to develop STFT and AF synthesis algorithms that can be used to implement a variety of time-varying signal processing operations, no such synthesis techniques have thus far been developed for the WD. In this paper, signal synthesis algorithms that work directly with the real-valued high-resolution WD will be derived. Examples of how this WD synthesis procedure can be used to perform time-varying filtering operations or signal separation will be given.