gebhart/patrepeval huggingface dataset:
Thermocyclic Behavior of Differently Stabilized and structured EB‐PVD thermal barrier coatings (1997)

Abstract The electron‐beam physical vapor deposition (EB‐PVD) process provides distinctive coatings of a unique columnar microstructure for gas turbine components. Main advantage of this structure is superior tolerance against straining, erosion and thermoshock, thus giving it a major edge in lifetime. This paper outlines the interaction between chemical composition and microstructural evolution EB‐PVD zirconia‐based thermal barrier coatings (TBCs) and their respective lifetimes in cyclic burner rig and furnace tests. Customizing TBC microstructure by adjusting EB‐PVD processing parameters is emphasized. A structural zone diagram for PVD is modified by interconnecting the influence of substrate rotation with microstructural evolutions. Finally, some basic aspects of single source and dual source evaporation are compared.
ROBOS: world modelling through an object system (1991)

A self-contained object system for robotic applications is developed and implemented. The main feature of the system, named ROBOS (robotic object system), is its object-oriented configuration and its suitability for high level interfaces. The robotic environment is integrated to this object system by means of object lists together with a message handling mechanism. The term object is not confined to physical objects; a task, a motion trajectory or a sensor response are all treated as objects. The task objects are organized in a hierarchical way and the task sequences are represented by means of a new strategy, named constructive task representation. The system maintains a uniform strategy for object definition, irrespective of the type of the item to be defined. An object is referred by a name and it is stored in the system together with the related structures. The message handling module is the main tool for reasoning the environment and its objects. The user interface and interaction with application programs are also achieved by the message handler. The system is provided with a built-in planner to sequence the task objects. The whole system is implemented in a LISP environment on an IBM 3090 computer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Li2Ni1-XMXO2 as An Additive Material in Cathode for High Energy Si-based Lithium Ion Battery (2009)

Abstract not Available.
A hydroxyphenyloxadiazole lithium complex as a highly efficient blue emitter and interface material in organic light-emitting diodes (2003)

We synthesized a hydroxyphenyloxadiazole lithium complex (LiOXD) as a blue light-emitting and electron injection/transport material to be used in double-layer organic electroluminescent devices. Devices with the concise configuration of ITO/TPD/LiOXD/Al showed bright blue EL emission centered at 468 nm with a maximum luminance of 2900 cd m−2. A current efficiency of 3.9 cd A−1 and power efficiency of 1.1 lm W−1 were obtained. LiOXD was also examined as an interface material. The efficiency of an ITO/NPB/Alq3/Al device increased considerably when LiOXD was inserted between Alq3 and aluminium. The improvement of the device characteristics with LiOXD approached that observed with the dielectric LiF salt.
A hydrogel pen for electrochemical reaction and its applications for 3D printing (2014)

A hydrogel pen consisting of a microscopic pyramid containing an electrolyte offers a localized electroactive area on the nanometer scale via controlled contact of the apex with a working electrode. The hydrogel pen merges the fine control of atomic force microscopy with non-linear diffusion of an ultramicroelectrode, producing a faradaic current that depends on the small electroactive area. The theoretical and experimental investigations of the mass transport behavior within the hydrogel reveal that the steady-state current from the faradaic reaction is linearly proportional to the deformed length of the hydrogel pen by contact, i.e. signal transduction of deformation to an electrochemical signal, which enables the fine control of the electroactive area in the nanometer-scale regime. Combined with electrodeposition, localized electrochemistry of the hydrogel pen results in the ability to fabricate small sizes (110 nm in diameter), tall heights (up to 30 μm), and arbitrary structures, thereby indicating an additive process in 3 dimensions by localized electrodeposition.
Mercury: hybrid centralized and distributed scheduling in large shared clusters (2015)

Datacenter-scale computing for analytics workloads is increasingly common. High operational costs force heterogeneous applications to share cluster resources for achieving economy of scale. Scheduling such large and diverse workloads is inherently hard, and existing approaches tackle this in two alternative ways: 1) centralized solutions offer strict, secure enforcement of scheduling invariants (e.g., fairness, capacity) for heterogeneous applications, 2) distributed solutions offer scalable, efficient scheduling for homogeneous applications.

We argue that these solutions are complementary, and advocate a blended approach. Concretely, we propose Mercury, a hybrid resource management framework that supports the full spectrum of scheduling, from centralized to distributed. Mercury exposes a programmatic interface that allows applications to trade-off between scheduling overhead and execution guarantees. Our framework harnesses this flexibility by opportunistically utilizing resources to improve task throughput. Experimental results on production-derived workloads show gains of over 35% in task throughput. These benefits can be translated by appropriate application and framework policies into job throughput or job latency improvements. We have implemented and contributed Mercury as an extension of Apache Hadoop / YARN.
Characterization of Cutaneous Photoxicity Induced by Topical Alpha-Terthienyl and Ultraviolet A Radiation (1986)

Alpha-terthienyl (alpha-T), a phototoxic thiophene compound isolated from marigolds (Tagetes species), affects cell membranes and does not appear to induce cytogenetic damage. This study was undertaken to investigate topical delivery of alpha-T and characterize its cutaneous phototoxicity in combination with long-wave UV radiation (UVA) in comparison with locally (intradermal) administered alpha-T. Percutaneous penetration (PC) of 0.1% and 1% alpha-T in a 3% Azone gel vehicle was studied in guinea pig skin in vitro and quantitated by UV fluorescence microscopy. Dose-dependent PC of epidermis, adnexae, and superficial dermis was demonstrated in vitro. Alpha-terthienyl (0.1% and 1%) in this vehicle was applied topically in vivo and irradiated with 30 J/cm2 UVA at intervals of 10 min-24 h. Maximum sensitization was achieved with irradiation 1 h following drug application. The clinical response was dose-dependent consisting of erythema, edema, crusting, erosion, and inhibition of hair growth and was observed 72 h to 7 days postirradiation. A comparable dose-dependent phototoxic response was observed when 5-500 micrograms alpha-T were injected intradermally and irradiated with UVA. These results indicated that low-dose topical alpha-T in a nonirritating vehicle can rapidly produce cutaneous photosensitization. Topical alpha-T/UVA may provide a selective and safer alternative approach for the photochemotherapy of psoriasis and other cutaneous diseases.
Wireless passive sensor networks (2009)

The primary challenge in wireless sensor network deployment is the limited network lifetime due to finite-capacity batteries. Hence, the vast majority of research efforts thus far have focused on the development of energy-efficient communication and computing mechanisms for WSNs. In this article a fundamentally different approach and hence completely new WSN paradigm, the wireless passive sensor network, is introduced. The objective of the WPSN is to eliminate the limitation on system lifetime of the WSN. In a WPSN power is externally supplied to the sensor network node via an external RF source. Modulated backscattering is discussed as an alternative communication scheme for WPSNs. The feasibility is investigated along with the open research challenges for reliable communication and networking in WPSNs.
Apolipoprotein B mRNA editing protein: a tool for dissecting lipoprotein metabolism and a potential therapeutic gene for hypercholesterolemia. (1996)

Apolipoprotein (apo) B mRNA editing protein is an essential catalytic component of the apoB mRNA editing enzyme complex. Its cDNA has been cloned recently from rats and humans. In the presence of other proteins of the editing enzyme complex, it will deaminate nucleotide 6666 in apoB mRNA, a cytidine residue, converting it to uridine. The end result of this reaction is the production of apoB-48 in place of apoB-100. The editing protein exists as a homodimer. It imparts editing activity to HepG2, a human hepatoma cell line, causing these cells to start producing apoB-48 in addition to apoB-100. Therefore, it can be used as a therapeutic agent to reduce apoB-100 production. Preliminary experiments in our laboratory indicate that somatic gene transfer of the editing protein is highly effective in lowering plasma low density lipoproteins.
Development of a Hydrogen Fueled Internal Combustion Engine Designed for Single Speed/Power Operation (1996)

<div class="htmlview paragraph">In the continuing development of a hydrogen fueled IC engine optimized for application to a generator set or hybrid vehicle, experiments were performed at Sandia National Laboratories on two engine configurations. The intent is to maximize thermal efficiency while complying with strict emissions standards. The initial investigation was conducted utilizing a spark ignited 0.491 liter single cylinder Onan engine and has progressed to a spark ignited 0.850 liter modified for single cylinder operation Perkins engine. Both combustion chamber geometries were “pancake” and achieved a compression ratio of 14:1. The engines were operated under premixed conditions. The results demonstrate that both engines can comply with the California Air Resources Board's proposed Equivalent Zero Emission Vehicle standards for NO<sub>x</sub> during operation at an equivalence ratio of 0.4. The Onan engine achieved an indicated thermal efficiency of 43% at 1800 RPM, as determined by integration of the pressure-volume relationships. Initial experiments with the lager displacement Parkins engine have realized a gain, relative to the Onan engine, in indicated thermal efficiency of 2% at 1800 RPM, and 15% at 1200 RPM.</div>
The Determination of Dehydroascorbic Acid and Ascorbic acid in the Serum and Synovial Fluid of Patients with Rheumatoid Arthritis (RA) (1985)

Using a novel high performance liquid chromatography (HPLC) determination of ascorbic acid and dehydroascorbic acid, we have measured the relative amounts of ascorbate and dehydroascorbate in 20 normal controls and in paired sera and synovial fluid from 13 patients with rheumatoid arthritis (RA). In complete contrast to previous published findings we were able to detect dehydroascorbate in normal human sera (12.0 +/- 3.7 mumol/l), while the mean and range of ascorbate measured in normals was 69.6 +/- 20.6 mumol/l. These findings were completely reversed in rheumatoid sera (21.8 +/- 8.6 mumol/l and 5.1 +/- 5.0 mumol/l for dehydroascorbate and ascorbic acid respectively). In several rheumatoid sera no ascorbate could be detected. In paired synovial fluid and serum samples, there was always more dehydroascorbate detected in synovial fluids than in the corresponding sera (p less than 0.01). The data suggests that the reduced level of ascorbate and increased level of dehydroascorbate may be a reflection of the increased antioxidant and free-radical scavenging activity of the vitamin in RA, especially within the inflamed joint.
Purification of the human histone H4 gene-specific transcription factors H4TF-1 and H4TF-2. (1988)

Transcription of the cell-cycle-regulated human histone genes increases approximately fivefold during S phase. One step toward the elucidation of the biochemical mechanisms that govern cell-cycle-regulated expression of these genes is to purify and characterize the transcription factors that regulate these promoters. Here, we describe the purification of two previously identified factors, H4TF-1 and H4TF-2, which bind the human histone H4 promoter. Purification was achieved through a combination of ion-exchange and oligonucleotide affinity chromatography. On the basis of analysis of purified fractions by SDS-polyacrylamide gels and UV cross-linking, we believe that H4TF-1 is two polypeptides of 105 and 110 kD. This factor binds to a GC-rich DNA sequence required for maximal expression of the H4 gene but does not bind to any Sp1 consensus elements tested. H4TF-2 is a 65-kD protein that binds specifically to sequences within that highly conserved H4 subtype-specific consensus promoter element. Both highly purified factors activated transcription in vitro only from H4 promoters that contained their binding sequences, demonstrating that H4TF-1 and H4TF-2 are H4-specific transcription factors that potentiate expression of this gene.
Advances in the Treatment of Menopausal Symptoms (2009)

Vasomotor symptoms and vaginal atrophy are both common menopausal symptoms. Hormone therapy is currently the only FDA-approved treatment for hot flashes. Current recommendations are to use the lowest dose of hormone therapy for the shortest period that will allow treatment goals to be met. Although the reanalysis of the WHI in 2007 by Roussow et al. provided evidence of coronary heart safety for users of hormone therapy under the age of 60 years and within 10 years of the onset of menopause, not all women desire or are candidates for hormone therapy. In this review we present an evidence-based discussion considering the effectiveness of hormonal and nonhormonal therapies for the relief of vasomotor symptoms and vaginal atrophy. Concern exists regarding systemic absorption of vaginal estrogen and possible adverse effects on the breast and uterus. Selective estrogen receptor modulators and estrogen agonists offer benefits through targeted estrogen agonist/antagonistic effects and are being evaluated with and without estrogen for symptomatic menopausal women. Centrally acting nonhormonal therapies that are effective for the relief of vasomotor symptoms include various antidepressants, gabapentin and clonidine. A limited number of clinical trials have been conducted with nonprescription remedies, including paced respiration, yoga, acupuncture, exercise, homeopathy and magnet therapy, and some, but not all of these, have been found to be more effective than placebo. Dietary herbal supplements, such as soy and black cohosh, have demonstrated mixed and inconclusive results in placebo-controlled trials. Potential therapies for vasomotor symptoms and vaginal atrophy require randomized, placebo-controlled trials of sufficient duration to establish efficacy and safety. Agents under investigation for vasomotor symptoms relief include neuroactive agents, such as gabapentin and desvenlafaxine; an estrogen receptor-beta-targeted herbal therapy, MF-101; and the selective estrogen receptor modulator, bazedoxifene, paired with estrogen.
Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs (2017)

VOLUME 280 (2005) PAGES 30384–30391 We would like to acknowledge that the controls shown in Fig. 5, B and C, and Fig. 6C have also been used in a previous publication (Bykov, V. J., Issaeva, N., Shilov, A., Hultcrantz, M., Pugacheva, E., Chumakov, P., Bergman, J., Wiman, K. G., and Selivanova, G. (2002) Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat. Med. 8, 282–288). In Fig. 5, B and C, the control lanes in the gel shift assays, i.e. no treatment and supershift with PAb421 or PAb1801 antibody in the absence of test compound, are the same as those shown in the previous paper. Likewise, in Fig. 6C, the p53 immunostaining and Hoechst staining of untreated control cells is the same as that shown in the previous paper. The reason for this mistake is that we examined the two novel mutant p53-targeting compounds PRIMA-1 and MIRA-1 side by side in several assays and then decided to publish our results in two separate papers. However, it should be noted that these controls can serve equally well as controls for both compounds. Therefore, this does not change the validity of the data nor the conclusions from the experiments.
Photo-induced effects on self-organized TiO<sub>2</sub>nanotube arrays: the influence of surface morphology (2008)

Self-organized TiO(2) nanotubes with packed, vertically aligned morphology and different lateral characteristics were grown on Ti metal substrates by controlled electrochemical anodization in phosphate/HF and ethylene glycol/HF electrolytes. The wetting, photo-induced superhydrophilicity, and photocatalytic activity of the nanotubular materials were investigated under ultraviolet irradiation. The photoactivity of the TiO(2) nanotube arrays was analysed in terms of their morphological characteristics that were determined by means of scanning electron microscopy and atomic force microscopy in conjunction with geometrical modelling. The wetting and the UV-induced superhydrophilicity could be accordingly modelled by the Cassie-Baxter mode arising from the large scale roughness of the nanotubular arrays in combination with the Wenzel mode due to the small scale roughness induced by ridges at the outer tube surface. The photocatalytic activity of the TiO(2) nanotube arrays was further found to correlate quantitatively with the variation of the geometric roughness factor, verifying the strong impact of morphology on the photo-induced properties of the vertically oriented TiO(2) tubular architecture.
Proposition of an offline learning current modulation for torque-ripple reduction in switched reluctance motors: design and experimental evaluation (2002)

A new offline current modulation using a neuro-fuzzy compensation scheme for torque-ripple reduction in switched reluctance motors is presented. The main advantage of the proposed technique is that the torque signal is unnecessary. The compensating signal is learned prior to normal operation in a self-commissioning run, capturing the necessary current shape to reduce the torque ripple. Simulation results verify first the effects of speed and then load changes on the compensator performance. Implementation of the proposed technique in a laboratory prototype shows the feasibility and accuracy of the respective offline scheme.
Synthesis of Pyrroles and Condensed Pyrroles as Anti-Inflammatory Agents with Multiple Activities and Their Molecular Docking Study (2015)

We herein disclose a series of novel pyrrole derivatives as well as fused pyrrolopyridines 6a,b and 7a,b, pyrrolopyrazoles 8a, b, pyrrolo[2,3-d]pyrimidine derivatives 10a-d, 12a,b, 14a,b, 18a,b, 20a,b, 21a,b, 22a,b, 23a,b, 24a,b, 31a,b, 36a,b, 40a,b, pyrrolo[1,2,6]thiadiazine derivatives 19a,b, pyrrolotriazolopyrimidines 25a,b, 26a,b, 27a,b and 28a,b, pyrrolo[2,3-d][1,2,3]triazine derivatives 32a,b and pyrrolo[2,3-d][1,3]oxazine derivatives 39a,b as novel compounds. All compounds were evaluated for their anti-inflammatory, analgesic (compared to the reference drug Indomethacin) and antimicrobial activities (compared to the reference drug Ampicillin and Fluconazole). Compounds 4d, 5b-d, 6a,b, 9c,d, 10d, 12ab, 13b, 19a,b, 21b, 23b, 31a,b, 38b and 40a were found to be the most active anti-inflammatory drugs exhibiting potency ranging from 1 - 1.01 compared to the reference drug indomethacin. In addition to docking study of these highly active twenty compounds against the active site of cyclooxygenase-2 enzyme (COX-2), among the tested compounds, compounds 5d, 9d, 11b, 12a, 13b and 32a showed multiple activities; anti-inflammatory, analgesic and anti-bacterial activities.
Driver behavior analysis and route recognition by Hidden Markov Models (2008)

In this investigation, driver behavior signals are modeled using Hidden Markov Models (HMM) in two different and complementary approaches. The first approach considers isolated maneuver recognition with model concatenation to construct a generic route (bottom-to-top), whereas the second approach models the entire route as a dasiaphrasepsila and refines the HMM to discover maneuvers and parses the route using finer discovered maneuvers (top-to-bottom). By applying these two approaches, a hierarchical framework to model driver behavior signals is proposed. It is believed that using the proposed approach, driver identification and distraction detection problems can be addressed in a more systematic and mathematically sound manner. We believe that this framework and the initial results will encourage more investigations into driver behavior signal analysis and related safety systems employing a partitioned sub-module strategy.
Switch as maintenance to elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate: week 48 results in a clinical cohort (2017)

In this clinical cohort of virologically suppressed patients switching to STR, most subjects had adequate elvitegravir C 24 values with a high proportion maintaining virological suppression with no residual viraemia until W48.
Antimicrobial Activities of Naphthazarins from <i>Arnebia </i><i>e</i><i>uchroma</i> (2002)

Bioassay-directed fractionation of extract of Arnebia euchroma led to the isolation of alkannin (1), shikonin (2), and their derivatives (3-8) as the active principles against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The stereochemistry of alpha-methylbutyryl alkannin (8) is revealed for the first time, and the antimicrobial activity of 8 was compared with its corresponding diastereomer (9). The derivatives 3-9 showed stronger anti-MRSA activity [minimum inhibitory concentrations (MICs) ranged from 1.56 to 3.13 microg/mL] than alkannin or shikonin (MIC = 6.25 microg/mL). Anti-MRSA activity of derivatives was bactericidal with minimum bactericidal concentration (MBC)/MIC < or = 2. In a time-kill assay, the bactericidal activity against MRSA was achieved as rapidly as 2 h. The derivatives 3-9 were also active against vancomycin-resistant Enterococcus faecium (F935) and vancomycin-resistant Enterococcus faecalis (CKU-17) with MICs similar to those with MRSA. Aromatic ester derivatives were also synthesized for antimicrobial activity comparison. None of these compounds were active against Gram-negative bacteria tested. Their cytotoxicity was also evaluated on selected cancer cell lines, and they expressed their activity in the range 0.6-5.4 microg/mL (CD(50)). Our results indicate that the ester derivatives of alkannin are potential candidates of anti-MRSA and anti-VRE agents with antitumor activity.
Synthesis of a Fluorobenzoxazine Derivative and Its Analogues (1994)

Journal Article Synthesis of a Fluorobenzoxazine Derivative and Its Analogues Get access Ichiki Takemoto, Ichiki Takemoto Organic Synthesis Research Laboratory, Sumitomo Chemical Co., Ltd., 10-1 Tsukahara 2-chome, Takatsuki, Osaka 569, Japan To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Kaori Yamasaki, Kaori Yamasaki Organic Synthesis Research Laboratory, Sumitomo Chemical Co., Ltd., 10-1 Tsukahara 2-chome, Takatsuki, Osaka 569, Japan Present address: Tsukuba Research Laboratory, Sumitomo Chemical Co., Ltd., Tsukuba Ibaraki 300-32, Japan. Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Kaminaka Hiroshi Kaminaka Organic Synthesis Research Laboratory, Sumitomo Chemical Co., Ltd., 10-1 Tsukahara 2-chome, Takatsuki, Osaka 569, Japan Present address: Koei Chemical Co., Ltd., 2-12-13, Hanaten-nishi, Joto-ku, Osaka 536, Japan. Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 58, Issue 4, 1 January 1994, Pages 788–789, https://doi.org/10.1271/bbb.58.788 Published: 01 January 1994 Article history Received: 21 October 1993 Published: 01 January 1994