gebhart/patrepeval huggingface dataset:
Automated quality tracking (1990)

The development of computer-aided software engineering tools, with their undoubted advantages, needs to be parallelled by developments in automated quality measurement and tracking tools. The authors describe an initial approach taken by them in this respect: providing an automated method of tracking the progress of functional verification testing against a defect removal model (DRM). The automated tracking package described, comprises the following general elements: a controlling routine which inputs data from a driver plan file and a PTR summary file and computes plotting information which it passes to a graphical display routine for plotting; subsidiary routines to extract a raw PTR summary from the database for the product being tracked; subsidiary routines to refine this summary into, in the example given, a list of FV PTRs; a flat file driver plan; and files giving the chart format and data definition files which the graphical display manager uses to plot the chart. >
KERATINOCYTE GROWTH FACTOR RECEPTOR CORRELATES WITH VENOUS INVASION VIA VASCULAR ENDOTHELIAL GROWTH FACTOR IN PANCREATIC CANCER (2005)

Purpose: Keratinocyte growth factor (KGF)/fibroblast growth factor-7 (FGF-7), an angiogenic and mitogenic polypeptide that is mainly synthesized by mesenchymal cells, has been implicated in cancer growth and tissue development and repair. Its actions are dependent on binding to a specific cell-surface KGF receptor (KGFR). In the present study, we investigated the expression and role of KGF and KGFR in human pancreatic cancer tissues. Methods: Immunohistochemically, the expression of KGF, KGFR and VEGF in human pancreatic cancer tissues were examined. Moreover, we evaluated co-expression of KGF and KGFR, and correlation with clinicopathological factors. Result: KGFR was localized in cytoplasm and/or membrane of cancer cells in 22 of the 53 (41.5%) patients, and KGF immunoreactivity was detected in cytoplasm of cancer cells in 18 of the 53 (34.0%) patients. Clinicopathologically, KGF and KGFR expression was highly correlated with venous invasion respectively. Moreover, co-expression of KGF and KGFR correlated significantly with venous invasion, VEGF expression and poor prognosis. Conclusion: These findings suggest that co-expression of KGF and KGFR might play an important role in enhancing venous invasion in pancreatic cancer cases by modulating the capacity of angiogenesis.
Pathophysiological role of autoantibodies against G-protein-coupled receptors in the cardiovascular system. (2005)

After more than 15 years of intensive research in the field of functional autoantibodies (AAB) directed against G-protein-coupled receptors, there is growing evidence of a causal involvement of AAB in various cardiovascular diseases such as dilated cardiomyopathy, peripartum cardiomyopathy, malignant and essential hypertension, and preeclampsia. It has been indicated that AAB against beta-1 adrenergic receptor, alpha-1 adrenergic receptor, angiotensin-II receptor AT(1) and muscarinic M(2)-receptors undergo agonist-like actions on the corresponding receptor and induce a permanent stimulation of G-protein-coupled signal cascades, which may cause Ca(2+) overload and cardiomyocyte destruction.Furthermore, the present review describes how G-protein-coupled receptor AAB are able to activate transcription factor nuclear factor-kappa B, which may regulate the expression of genes involved in immune and inflammatory responses.
Theoretical Considerations, Design, and Evaluation of a Cascade Impactor (1967)

Abstract A cascade impactor of the multijet, round-hole design was developed that provides easy alteration of impactor stages and variation of air flow. The instrument was evaluated by empirical observation, correlation of mass distributions of aerosols as determined with the impactor versus membrane filter samples, determination of stage efficiencies, and case loss studies.
High-Speed Countercurrent Chromatography Separation of Taxol and Related Diterpenoids from <i>Taxus Baccata</i> (1992)

Abstract Taxol and related taxane diterpenoids were isolated from pre-purified extracts of stem-barks of Taxus bacccata by HSCCC. The described method allowed to obtain a mixture of taxol and cephalomannine without any other interfering constituent and furthermore a partial separation of taxol (40 % of the total recovery) from cephalomannine. In addition, the HPLC and TLC separation conditions of these compounds for the semi-preparative and analytical purposes were improved. The proposed HSCCC method could be adapted to the scaling-up separation of taxol from vew material.
Liquid Chromatography-Tandem Mass Spectrometry for the Quantification of Tobacco-Specific Nitrosamine-Induced DNA Adducts in Mammalian Cells (2017)

Quantification of DNA lesions constitutes one of the main tasks in toxicology and in assessing health risks accompanied by exposure to carcinogens. Tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) can undergo metabolic transformation to give a reactive intermediate that pyridyloxobutylates nucleobases and phosphate backbone of DNA. Here, we reported a highly sensitive method, relying on the use of nanoflow liquid chromatography-nanoelectrospray ionization-tandem mass spectrometry (nLC-nESI-MS/MS), for the simultaneous quantifications of O<sup>6</sup>-[4-(3-pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine (O<sup>6</sup>-POBdG) as well as O<sup>2</sup>- and O<sup>4</sup>-[4-(3-pyridyl)-4-oxobut-1-yl]-thymidine (O<sup>2</sup>-POBdT and O<sup>4</sup>-POBdT). By using this method, we measured the levels of the three DNA adducts with the use of 10 μg of DNA isolated from cultured mammalian cells exposed to a model pyridyloxobutylating agent, 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNKOAc). Our results demonstrated, for the first time, the formation of O<sup>4</sup>-POBdT in naked DNA and in genomic DNA of cultured mammalian cells exposed with NNKOAc. We also revealed that the levels of the three lesions increased with the dose of NNKOAc and that O<sup>2</sup>-POBdT and O<sup>4</sup>-POBdT could be subjected to repair by the nucleotide excision repair (NER) pathway. The method reported here will be useful for investigations about the involvement of other DNA repair pathways in the removal of these lesions and for human toxicological studies in the future.
Three dimensional printing of metamaterial embedded geometrical optics (MEGO) (2019)

Three-dimensional printers have revolutionized many scientific fields with its low-cost, accessibility and ease of printing. In this paper, we show how stereolithography (SLA) based 3D printers can enable realization of innovative 3D optical devices formed through the fusion of metamaterials with geometrical optics or MEGO. It utilizes a combination of desktop SLA 3D printer and metal deposition/coating systems. Using this approach, we present innovative metamaterial embedded optical components such as mushroom-type metamaterials, curved wide-angle metamaterial absorbers/reflectors and a frequency selective moth eye hemispherical absorber. Finally a unique MEGO device formed through the fusion of a frequency selective metamaterial with an optical parabolic reflector has been demonstrated that combines their individual properties in a single device. The fabricated MEGO devices operate in the millimeter wave frequency range. Simulation and measurement results using terahertz continuous-wave spectrometer validate their functionality and performance. With improving resolution in 3D printing, MEGO devices will be able to reach Terahertz and optical frequencies in the near future.
Topical treatment with coenzyme <scp>Q</scp>10‐containing formulas improves skin's <scp>Q</scp>10 level and provides antioxidative effects (2015)

Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid-soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of external stress factors in human skin. Here, it is shown that topical Q10 treatment is beneficial with regard to effective Q10 replenishment, augmentation of cellular energy metabolism, and antioxidant effects. Application of Q10-containing formulas significantly increased the levels of this quinone on the skin surface. In the deeper layers of the epidermis the ubiquinone level was significantly augmented indicating effective supplementation. Concurrent elevation of ubiquinol levels suggested metabolic transformation of ubiquinone resulting from increased energy metabolism. Incubation of cultured human keratinocytes with Q10 concentrations equivalent to treated skin showed a significant augmentation of energy metabolism. Moreover, the results demonstrated that stressed skin benefits from the topical Q10 treatment by reduction of free radicals and an increase in antioxidant capacity.
Analytics-driven asset management (2011)

Asset-intensive businesses across industries rely on physical assets to deliver services to their customers, and effective asset management is critical to the businesses. Today, businesses may make use of enterprise asset-management (EAM) solutions for many asset-related processes, ranging from the core asset-management functions to maintenance, inventory, contracts, warranties, procurement, and customer-service management. While EAM solutions have transformed the operational aspects of asset management through data capture and process automation, the decision-making process with respect to assets still heavily relies on institutional knowledge and anecdotal insights. Analytics-driven asset management is an approach that makes use of advanced analytics and optimization technologies to transform the vast amounts of data from asset management, metering, and sensor systems into actionable insight, foresight, and prescriptions that can guide decisions involving strategic and tactical assets, as well as customer and business models.
PCM picture transmission (1965)

The transmission of pictures by pulse code modulation (PCM) has been investigated by various researchers <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1, 2</sup> for more than a decade. Recently, interest has reached a new high, partly because of the possible military and space applications. The purpose of the present article is to describe briefly some of the research work being carried on in Pcm picture transmission at the Cognitive Information Processing Group (CIPG) of the Research Laboratory of Electronics, Massachusetts Institute of Technology. Many other groups, notably the Bell Telephone Laboratories researchers, are also working extensively in this area.
Binding of beta 2 glycoprotein I to activated polystyrene and its recognition by human IgG autoantibodies. (1995)

Beta 2 glycoprotein I (apolipoprotein H, beta 2GPI) is involved in the formation of epitope(s) recognized by clinically relevant autoantibodies from patients with antiphospholipid syndrome. We studied the binding of beta 2GPI to chemically activated polystyrene in a microtitre plate format. Adsorption isotherms (at 37 degrees C) were generated for beta 2GPI on activated polystyrene and on unactivated polystyrene, with both human serum antibodies and rabbit polyclonal IgG antibodies as probes, and horseradish peroxidase (HRP)-tagged anti-IgG to detect binding. Additionally, beta 2GPI was biotinylated and isotherms were developed by using HRP-streptavidin as the recognition sequence. Human serum autoantibodies, which did not precipitate beta 2GPI in solution, yielded a characteristic chemisorption isotherm on activated polystyrene but did not recognize beta 2GPI bound to untreated polystyrene. The rabbit IgG, which did precipitate beta 2GPI in solution, detected beta 2GPI bound to both activated polystyrene and, to a lesser extent, to untreated polystyrene. The binding of beta 2GPI to untreated polystyrene was confirmed by the use of biotinylated beta 2GPI. To assess the prevalence of IgG anti-beta 2GPI autoantibodies, we surveyed 113 sera submitted to our laboratory for anticardiolipin antibody (aCL) testing. Only nine (8%) had anti-beta 2GPI activity greater than two standard deviations above the mean for those sera in which aCL activity was within normal limits. We conclude that epitope presentation of beta 2GPI for human autoantibody binding is dependent on surface properties of the polystyrene, and that beta 2GPI autoantibodies are found only in a subpopulation of sera positive for aCL.
1.3 µm InGaAs/GaAs strained quantum well laserswith InGaP cladding layer (1994)

Using MOVPE, we fabricated strained quantum well 1.3 µm lasers with an InGaP cladding layer on a GaAs substrate. The lasers had a high gain coefficient of 60 cm-1. Lasers with high reflection facets had a low threshold current density of 500 A/cm2, and a high characteristic temperature of 100 K.
Analysis and Mitigation of the CubeSat Dynamic Environment (2013)

A vibration model was developed for CubeSats inside the Poly-Picosatellite Orbital Deployer (P-POD). CubeSats are fixed in the Z axis of deployers, and therefore resonate with deployer peaks. CubeSats generally start fixed in the X and Y axes, and then settle into an isolated position. CubeSats do not resonate with deployers after settling into an isolated position. Experimental data shows that the P-POD amplifies vibration loads when CubeSats are fixed in the deployer, and vibration loads are reduced when the CubeSats settle into an isolated position. A concept for a future deployer was proposed that isolates CubeSats from the deployer at the rail interface using viscoelastic foam sandwiched in the deployer rails. By creating an isolator frequency far below the deployer resonant frequency, CubeSats loads are not amplified at the deployer’s resonant peak. Feasibility tests show that CubeSat vibration loads can be reduced to 50% of the vibration input in certain cases. Testing also shows that it is much easier to define vibration loads for isolated CubeSats than CubeSats in the current P-POD.
Health-related quality of life (HRQoL) in patients (pts) with progressive, poorly differentiated, extra-pulmonary neuroendocrine carcinoma (PD-EP-NEC) enrolled in NET-02: A phase II trial of liposomal irinotecan (nal-IRI)/5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line therapy. (2022)

293 Background: NET-02 was a multi-centre, randomised (1:1), non-comparative phase II trial of nal-IRI/5-FU/folinic acid (ARM A) or docetaxel (ARM B) in pts with progressive PD-EP-NEC, aimed at selecting a treatment for evaluation in a phase III trial. Primary analysis (N = 58) showed ARM A, but not ARM B, achieved the target 6-month progression-free survival rate primary endpoint (McNamara et al. ASCO 2022). HRQoL was a secondary endpoint in NET-02. Methods: HRQoL was assessed using the EORTC QLQ-C30 and GINET21 (at baseline (BL), 6-weekly intervals and at disease progression). The mean change from BL was estimated for each scale by timepoint and treatment arm. Results are presented where there were ≥4 responses per time point. Scores were considered stable if they did not change by > 10 points from BL. The mean BL C30 scores for all pts were compared to United Kingdom (UK) population normative C30 data using a 2-sample t-test. Results: Fifty-four of 58 pts (93%) completed a BL questionnaire; of these, 39 (72%) completed ≥1 post-BL questionnaire, with 21 (51%) completing questionnaires at progression. Global health status (GHS) and all functional scales in ARM A remained stable from BL to intervals pre-progression, with a sustained improvement in role functioning observed post-BL. In ARM B, GHS and all C30 functional scales decreased by > 10 points between BL and week 18 (worsening of QoL). Both arms had a > 10-point increase from BL in constipation and diarrhoea in ≥1 post-BL time point. In ARM A, pain, insomnia and financial problems decreased from BL. No C30 symptom scales in ARM B were consistently lower post-BL. Patterns of change in GINET21 mean score were similar in both arms: body image, disease-related worries, information/communication, sexual function and social function all had a > 10-point reduction in score from BL (indicating improvement in symptoms/problems); endocrine and gastrointestinal symptoms remained stable; muscle/bone pain varied across time points, initially showing a reduction in pain followed by an increase, compared to BL. In comparison to the UK C30 norms (BL all pts), 11 of 15 C30 scales did not significantly differ (P > 0.05). Mean scores for fatigue and appetite loss were significantly higher than UK C30 norms (worse symptoms in pts from NET-02) (P = 0.03, P = 0.0003 respectively). However, emotional functioning and GHS were significantly better in pts from NET-02 (P = 0.001, P = 0.03 respectively). Role and social functioning were lower in pts from NET-02 (both P = 0.06) (poorer level of functioning). Conclusions: HRQoL was maintained and potentially improved with nal-IRI/5-FU/folinic acid, but not docetaxel. Compared to the UK general population, BL QoL did not substantially differ in pts from NET-02. Clinical trial information: NCT03837977.
Sulfazecin analogues. The preparation of 4-(trifluoromethyl)-1-sulfo-2-azetidinone derivatives (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfazecin analogues. The preparation of 4-(trifluoromethyl)-1-sulfo-2-azetidinone derivativesPat F. Bevilacqua, Dennis D. Keith, and John L. RobertsCite this: J. Org. Chem. 1984, 49, 8, 1430–1434Publication Date (Print):April 1, 1984Publication History Published online1 May 2002Published inissue 1 April 1984https://pubs.acs.org/doi/10.1021/jo00182a022https://doi.org/10.1021/jo00182a022research-articleACS PublicationsRequest reuse permissionsArticle Views675Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Implementation of 5-DOF apparatus used for adhesive spray and roughing of shoe upper (2008)

In shoe manufacturing, in order to attach the upper with the corresponding sole, it is necessary to ‘scrape’ certain material off the upper surface so that the glue can penetrate the leather and adhere; an operation called ‘roughing’. This paper presents the implementation of an innovative apparatus for roughing and adhesive spray of a shoe upper. The accuracy needed to follow the complex 3D (3 dimensional) paths and require a considerable degree of flexibility. In order to meet these server requirements, we have designed a 5-DOF (degree of freedom) apparatus. Firstly, the work trajectory on shoe sole was obtained in the camera vision system with structured light. And it was discreted to obtain the position and normal vector of the discrete point. Then we derive the input of the motors by kinematics analysis from the normal vector. Thus, the normal vector of the tool and the discrete point are coincidence. At the moment, the position of the tool is determined. Finally, the measurement of the translation is derived from the kinematics using the difference between the current position of the discrete point and the tool. And the discrete point and the work point will match by inputting the measurement to the translation mechanism. Then we use the method mentioned above to implement the spray and roughing of shoe upper.
Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain (2018)

Nivolumab combined with ipilimumab had clinically meaningful intracranial efficacy, concordant with extracranial activity, in patients with melanoma who had untreated brain metastases. (Funded by Bristol-Myers Squibb and the National Cancer Institute; CheckMate 204 ClinicalTrials.gov number, NCT02320058 .).
Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis (2009)

Multiplex protein technology has the potential to identify biomarkers for the differentiation, classification and improved understanding of the pathogenesis of interstitial lung disease. The aim of this study was to determine whether a 30-inflammatory biomarker panel could discriminate between healthy controls, sarcoidosis and systemic sclerosis (SSc) patients independently of other clinical indicators. We also evaluated whether a panel of biomarkers could differentiate between the presence or absence of lung fibrosis in SSc patients. We measured 30 circulating biomarkers in 20 SSc patients, 21 sarcoidosis patients and 20 healthy controls using Luminex bead technology and used Fisher's discriminant function analysis to establish the groups of classification mediators. There were significant differences in median concentration measurements between study groups for 20 of the mediators but with considerable range overlap between the groups, limiting group differentiation by single analyte measurements. However, a 17-analyte biomarker model correctly classified 90% of study individuals to their respective group and another 14-biomarker panel correctly identified the presence of lung fibrosis in SSc patients. These findings, if they are corroborated by independent studies in other centres, have potential for clinical application and may generate novel insights into the modulation of immune profiles during disease evolution.
Linearly Parameterized Bandits (2010)

We consider bandit problems involving a large (possibly infinite) collection of arms, in which the expected reward of each arm is a linear function of an r-dimensional random vector Z ∈ ℝ r , where r ≥ 2. The objective is to minimize the cumulative regret and Bayes risk. When the set of arms corresponds to the unit sphere, we prove that the regret and Bayes risk is of order Θ(r √T), by establishing a lower bound for an arbitrary policy, and showing that a matching upper bound is obtained through a policy that alternates between exploration and exploitation phases. The phase-based policy is also shown to be effective if the set of arms satisfies a strong convexity condition. For the case of a general set of arms, we describe a near-optimal policy whose regret and Bayes risk admit upper bounds of the form O(r √T log 3/2 T).