gebhart/patrepeval huggingface dataset:
Glutathione Transferase Activities and Herbicide Selectivity in Maize and Associated Weed Species (1996)

The role of glutathione transferases (GSTs) in the selectivity of the herbicides alachlor, atrazine, fluorodifen and metolachlor, which are detoxified by glutathione conjugation in plants, was determined in seedlings of maize (Zeamays L.) and the associated weed species Abutilon theophrasti Medic., Digitariasanguinalis (L.) Scop. Echinochloa crus-galli (L.) Beauv., Panicum miliaceum (L.), Setaria faberi Herrm. and Sorghum bicolor (L.) Moench. The availability of glutathione was also determined in all species and tissue concentrations were found to be in the range 120–160 μm for all species except D. sanguinalis and S. bicolor, which contained half this amount. GST activities toward the herbicides were determined in crude protein extracts from the plants using HPLC to quantify the biosynthesis of the herbicide conjugates. The specific activities of the GSTs toward the substrates were in the order alachlor>fluorodifen> atrazine>metolachlor in all species except A. theophrasti, where fluorodifen was a better substrate than alachlor. In most cases there was a good correlation between GST activities and the selectivity of the herbicides applied pre-emergence. In the case of atrazine, GST activities were also related to the relative rates of herbicide conjugation in vivo. In contrast, there was no simple relationship between glutathione availability and the selectivity of the herbicides. However, with alachlor there was evidence that glutathione availability was limiting GST activity and influencing tolerance.
Finite Element Analysis of Thin-Walled Structures (1988)

This book describes current developments in finite element analysis and the design of certain types of thin-walled structures.  The first three chapters lay the foundations for the development and use of finite elements for thin-walled structures, look at finite elements packages and discuss data input and mesh arrangements.  The final four chapters use the finite element method to assist in the solution of thin-walled structure problems.  Some of the problems solved include; water and air inflated structures; axisymmetric thin shells; ship structures and offshore structures.  This book will be an interest to design engineers, researchers and postgraduates.
3D morphable face models revisited (2009)

In this paper we revisit the process of constructing a high resolution 3D morphable model of face shape variation. We demonstrate how the statistical tools of thin-plate splines and Procrustes analysis can be used to construct a morphable model that is both more efficient and generalises to novel face surfaces more accurately than previous models. We also reformulate the probabilistic prior that the model provides on the distribution of parameter vector lengths. This distribution is determined solely by the number of model dimensions and can be used as a regularisation constraint in fitting the model to data without the need to empirically choose a parameter controlling the trade off between plausibility and quality of fit. As an example application of this improved model, we show how it may be fitted to a sparse set of 2D feature points (approximately 100). This provides a rapid means to estimate high resolution 3D face shape for a face in any pose given only a single face image. We present experimental results using ground truth data and hence provide absolute reconstruction errors. On average, the per vertex error of the reconstructed faces is less than 3.6 mm.
Viral Replication and Development of Specific Immunity in Macaques after Infection with Different Measles Virus Strains (1994)

Cynomolgus monkeys (Macaca fascicularis) were experimentally infected with a wild type measles virus (MV) strain (MV-BIL). Following intratracheal inoculation with different infectious doses, the virus could be isolated from peripheral blood mononuclear cells (PBMC), lung lavage cells, and pharyngeal cells. The kinetics of the cell-associated viremia was similar in all infected animals. They developed specific serum IgM, IgG, and neutralizing antibody responses as well as MV-specific T cell-mediated immunity. Monkeys infected intratracheally or intramuscularly with the wild type MV-Edmonston or the attenuated MV-Schwartz strain showed a lower level of PBMC-associated viremia and less pronounced specific IgM responses. Nine months after infection with MV strains, all of the monkeys were protected from intratracheal reinfection with MV-BIL. This monkey model is suitable for study of new generations of vaccines and vaccination strategies for measles.
Emotion Recognition: A Pattern Analysis Approach (2014)

<ul><li>Offers both foundations and advances on emotion recognition in a single volume</li><li>Provides a thorough and insightful introduction to the subject by utilizing computational tools of diverse domains</li><li>Inspires young researchers to prepare themselves for their own research</li><li>Demonstrates direction of future research through new technologies, such as Microsoft Kinect, EEG systems etc.</li></ul>
Intraoperative Radiotherapy With INTRABEAM: Technical and Dosimetric Considerations (2018)

IORT may be delivered with a variety of site-specific applicators. Appropriate applicator use is paramount for safe, effective, and efficient IORT delivery. Results of this study should help clinicians assure optimized target dose coverage and reduced normal tissue exposure.
X-Ray Absorption and Soft X-Ray Fluorescence Analysis of Kdp Optics (2000)

Potassium Dihydrogen Phosphate (KDP) is a non-linear optical material used for laser frequency conversion and optical switches. Unfortunately, when KDP crystals are coated with a porous silica anti-reflection coating [1] and then exposed to ambient humidity, they develop dissolution pits [2,3]. Previous investigations [2] have shown that thermal annealing renders KDP optics less susceptible to pitting suggesting that a modification of surface chemistry has occurred. X-ray absorption and fluorescence were used to characterize changes in the composition and structure of KDP optics as a function of process parameters. KDP native crystals were also analyzed to provide a standard basis for interpretation. Surface sensitive total electron yield and bulk sensitive fluorescence yield from the K 2p, P 2p (L{sub 2,3}-edge) and O 1s (K-edge) absorption edges were measured at each process step. Soft X-ray fluorescence was also used to observe changes associated with spectral differences noted in the absorption measurements. Results indicate that annealing at 160 C dehydrates the surface of KDP resulting in a metaphosphate surface composition with K:P:O = 1:1:3.
Molecular Basis of Filtering Carbapenems by Porins from β-Lactam-resistant Clinical Strains of Escherichia coli (2015)

Integral membrane proteins known as porins are the major pathway by which hydrophilic antibiotics cross the outer membrane of Gram-negative bacteria. Single point mutations in porins can decrease the permeability of an antibiotic, either by reduction of channel size or modification of electrostatics in the channel, and thereby confer clinical resistance. Here, we investigate four mutant OmpC proteins from four different clinical isolates of Escherichia coli obtained sequentially from a single patient during a course of antimicrobial chemotherapy. OmpC porin from the first isolate (OmpC20) undergoes three consecutive and additive substitutions giving rise to OmpC26, OmpC28, and finally OmpC33. The permeability of two zwitterionic carbapenems, imipenem and meropenem, measured using liposome permeation assays and single channel electrophysiology differs significantly between OmpC20 and OmpC33. Molecular dynamic simulations show that the antibiotics must pass through the constriction zone of porins with a specific orientation, where the antibiotic dipole is aligned along the electric field inside the porin. We identify that changes in the vector of the electric field in the mutated porin, OmpC33, create an additional barrier by "trapping" the antibiotic in an unfavorable orientation in the constriction zone that suffers steric hindrance for the reorientation needed for its onward translocation. Identification and understanding the underlying molecular details of such a barrier to translocation will aid in the design of new antibiotics with improved permeation properties in Gram-negative bacteria.
ARCHIVO GENERAL DE LA UNAM (1987)

EL ENCARGADO DEL ARCHIVO GENREAL DE LA UNAM, LICENCIADO DAVID CAMPOS ORTIZ, INFORMO QUE ESTE PERMITE A LOS ESTUDIANTES DE ESCUELAS INCORPORADAS DISPONER DEL SERVICIO DE TRAMITACION DE COPIAS LEGALIZADAS DE DOCUMENTACION, ASI COMO A AQUELLOS QUE HAYAN CURSADO MAESTRIAS, ESPECIALIDADES O DOCTORADOS.
Voiding in Cu Technology through Photovoltaic-Driven Electrochemical Dissolution (2007)

Abstract It has been found that a process-design interaction involving very large capacitor arrays is capable of causing voiding in well-formed copper trenches. This voiding is believed to be caused by the electrochemical dissolution of copper driven by the photovoltaic effect realized at p-n junctions. A series of experiments was performed to reproduce this voiding in a laboratory environment using water and exposure to light or dark. The experiments were performed on two different size capacitor arrays. In addition, similar experiments were performed on a large capacitor array that uses the opposite dopant isolation scheme. Conversely, copper dendrite growth was observed at the features of interest instead of dissolution, even under flowing de-ionized water (DI) conditions. The results are discussed in the context of known copper-water electrochemical equilibria and design implications are discussed.
Management of antipsychotic treatment discontinuation and interruptions using model-based simulations (2012)

Due to the long half-life of paliperidone palmitate (25-49 days), putative therapeutic plasma concentrations persisted longest in simulated cases of complete discontinuation or treatment interruption. These simulations may help clinicians better conceptualize the impact of antipsychotic nonadherence on plasma concentrations, and the impact of medication-specific reinitiation strategies after intermittent nonadherence.
Authentication as a service: Shamir Secret Sharing with byzantine components (2018)

We present a practical methodology for securing the password-based authentication scheme. We propose a solution based on the well-known (k,n) threshold scheme of Shamir for sharing a secret, where in our case the secret is the password itself and (k,n) threshold scheme means that n password-derived secrets (shares) are created and k less than n shares are necessary and sufficient for reconstructing the password, while k-1 are not sufficient. The scheme is information-theoretic secure. Since each of the n shares is stored on a different host (shareholder), an attacker will need to compromise k different shareholders for obtaining an amount of data sufficient for reconstructing the secret. Furthermore, in order to be resistant to the compromising of the server (dealer) coordinating the shareholders we define a variant of the classic Shamir, where the Shamir's abscissae are unknown to dealer and shareholders, making the reconstruction impossible even in the case of dealer and shareholders compromised. In addition we use the Pedersen technique for allowing the verification of shares. For the described scenario we have designed two protocols: the registration (user's sign-up, to be carried out once), and authentication (user's login). We analyse several scenarios where dealer and/or shareholders are partially/totally compromised and confirm that none of them is enabling the attacker to break the authentication. Furthermore we focus on cases where one or more byzantine servers are presented, analysing the impact on the framework and show the adopted mechanisms to be safe against these kinds of attacks. We have developed a prototype demonstrating that our framework works correctly, effectively and efficiently. It provides a first feasibility study that will provide a base for structured and engineered cloud-based implementations aiming at providing an authentication-as-a-service.
GENETIC ANALYSIS OF AROMATIC MUTANTS OF <i>SALMONELLA TYPHIMURIUM </i> (1967)

A N aromatic (aro) mutant of Escherichia coli may demand for its growth tyrosine, phenylalanine, tryptophan, para-aminobenzoic acid, para-hydroxybenzoic acid and a sixth unknown factor, or only the first two, three, four or five of these (DAVIS 1952a). Biochemical analyses of the aromatic pathway by several workers have indicated the possible presence of seven sequential steps leading to chorismic acid biosynthesis in E. coli Chorismic acid is then converted to the above aromatic end products by individual pathways
Identification of glycinexylidide in patients treated with intravenous lidocaine (1973)

Glycinexylidide (GX) has been identified in the urine of 8 patients treated with intravenous infusions of lidocaine. The concentration of GX ranged from 1.0 to 2.7 Ilg per milliliter in the plasma of 3 of these patients. This di‐desethylated product of lidocaine metabolism, like the mono‐desethylated metabolite, monoethylglycinexylidide (MEGX) also has local anesthetic activity. Both compounds may contribute to central nervous system (CNS) toxicity in some patients treated with lidocaine.
Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance in Lep/Lep Mice (2002)

Obesity is a common nutritional problem often associated with diabetes, insulin resistance, and fatty liver (excess fat deposition in liver). Leptin-deficient Lep(ob)/Lep(ob) mice develop obesity and those obesity-related syndromes. Increased lipogenesis in both liver and adipose tissue of these mice has been suggested. We have previously shown that the transcription factor sterol regulatory element-binding protein-1 (SREBP-1) plays a crucial role in the regulation of lipogenesis in vivo. To explore the possible involvement of SREBP-1 in the pathogenesis of obesity and its related syndromes, we generated mice deficient in both leptin and SREBP-1. In doubly mutant Lep(ob/ob) x Srebp-1(-/-) mice, fatty livers were markedly attenuated, but obesity and insulin resistance remained persistent. The mRNA levels of lipogenic enzymes such as fatty acid synthase were proportional to triglyceride accumulation in liver. In contrast, the mRNA abundance of SREBP-1 and lipogenic enzymes in the adipose tissue of Lep(ob)/Lep(ob) mice was profoundly decreased despite sustained fat, which could explain why the SREBP-1 disruption had little effect on obesity. In conclusion, SREBP-1 regulation of lipogenesis is highly involved in the development of fatty livers but does not seem to be a determinant of obesity in Lep(ob)/Lep(ob) mice.
Secure roaming with identity metasystems (2008)

The notion of identity metasystem has been introduced as the means to ensure inter-operability among different identity systems while providing a consistent user experience. Current identity metasystems provide limited support for secure roaming: by "roaming" we refer to the ability of a user to use the same set of identities and credentials across different terminals. We argue that in order to support different types of roaming, the identity metasystem client should be structured as a set of distributable components. We describe such distributed client-side software architecture and how that architecture is implemented by adapting Novell's Bandit project. We use our implementation to demonstrate how credentials are stored in a trusted device in the form of a mobile phone but can be used on less trusted terminals in the form of PCs.
Association of a Reproducible Epigenetic Risk Profile for Schizophrenia With Brain Methylation and Function (2020)

We identified a reproducible blood DNA-methylation signature specific for schizophrenia that was correlated with altered functional DLPFC-HC coupling during working memory and mapped to methylation differences found in DLPFC postmortem samples. This indicates a possible epigenetic contribution to a schizophrenia intermediate phenotype and suggests that PMS could be of interest to be studied in the context of multimodal biomarkers for disease stratification and treatment personalization.
A Multi-Skilled Approach to Property Maintenance Considering Temporal, Spatial and Resource Constraints (2018)

With the continued increase in age of the United States housing and building stock, as well as the continued need to maintain properties across the U.S., the need for timely, cost-optimal maintenance is ever more critical. This paper proposes the application of a mathematical model to aid in the scheduling and assignment of construction and maintenance tasks, considering the multi-skilled workforce. The benefit of this approach is to take advantage of the economies of scale that can be developed using cross-functional skilled workers with varying levels of competence and efficiency. This approach schedules and assigns tasks using data from maintenance task software datasets, using the least-cost, competent worker available for the job while also considering the trade-off between skilled labor cost and travel costs, both in terms of travel wage and vehicle wear and tear. The model is enhanced to include pairing between a mentor and an apprentice, where combined efficiency and pairing costs are considered at the same time as travel costs. Due to the practical nature of this research, a case organization was used and data from that firm was analyzed so that operational insights into the necessity of such a model could be considered. The mathematical backbone of the optimization approach to multi-skilled resource allocation considers the temporal and spatial demands of a geographically dispersed property management program. Actual, as opposed to sample, data allows us to evaluate the real financial implications on the case firm, if such an approach to scheduling is used. The generalization of this data provides excellent fit for a model that can be used to assign the best capable worker to the most cost-efficient task, considering deadlines, priorities and availability. Results of this scheduling approach provide significant cost and resource reductions over the historical firm performance, though practical considerations should temper that expectation. The above approach offers exceptional scalability and adaptability with the continued advancement of algorithm approaches to network-distribution and peer-to-peer work platforms.
Magnetic and Mechanical Properties of Mn-Zn Ferrites with Fine Grain Sizes. (1992)

The Mn-Zn ferrite bodies with densities above 99.8% and fine grain sizes blow 5m were
Synthesis of Tin-Encapsulated Spherical Hollow Carbon for Anode Material in Lithium Secondary Batteries (2003)

The tributylphenyltin (TBPT)-encapsulated resorcinol (R)-formaldehyde (F) sol was prepared inside the micelles of cetyltrimethylammonium bromide (CTAB). This core-shell-type sol was polymerized and further carbonized to obtain nanosized Sn-encapsulated spherical hollow carbon. The size of spherical hollow carbon and Sn metal particles was controllable by changing the R/CTAB or TBPT/CTAB mole ratio, respectively. It is likely that, when tested as the anode in Li secondary batteries, the spherical hollow carbon acts as a barrier to prevent the aggregation of nanosized Sn particles and provides a void space for Sn metal particles to experience a volume change without a collapse of carbon shell, giving rise to a better cycle performance than that of pure Sn metal.
Mechanisms of Ionizing Radiation Surface Effects on Transistors (1966)

Ionizing radiation effects on silicon planar bipolar transistors to determine degradation mechanisms
DMT analogues: <i>N</i>-ethyl-<i>N</i>-propyltryptamine and <i>N</i>-allyl-<i>N</i>-methytryptamine as their hydrofumarate salts (2020)

The solid-state structures of the hydro-fumarate salts of two <i>N</i>,<i>N</i>-di-alkyl-tryptamines, namely <i>N</i>-ethyl-<i>N</i>-propyl-tryptammonium (EPT) hydro-fumarate {systematic name: [2-(1<i>H</i>-indol-3-yl)eth-yl](meth-yl)propyl-aza-nium 3-carb-oxy-prop-2-enoate}, C<sub>15</sub>H<sub>23</sub>N<sub>2</sub> <sup>+</sup>·C<sub>4</sub>H<sub>3</sub>O<sub>4</sub> <sup>-</sup>, and <i>N</i>-allyl-<i>N</i>-methyl-tryptammonium (MALT) hydro-fumarate {systematic name: [2-(1<i>H</i>-indol-3-yl)eth-yl](meth-yl)(prop-2-en-1-yl)aza-nium 3-carb-oxy-prop-2-enoate}, C<sub>14</sub>H<sub>19</sub>N<sub>2</sub> <sup>+</sup>·C<sub>4</sub>H<sub>3</sub>O<sub>4</sub> <sup>-</sup>, are reported. Both compounds possess a protonated tryptammonium cation, and a hydro-fumarate anion in the asymmetric unit. The ethyl group of the EPT cation is modeled as a two-component disorder with 50% occupancy for each component. In the extended structure, N-H⋯O and O-H⋯O hydrogen bonds generate infinite two-dimensional networks parallel to the (001) plane for both compounds.
<i>S</i>-adenosyl-<scp>l</scp>-methionine modulates Na+ + K+-ATPase activity in rat colonic basolateral membranes (1988)

Rat colonic basolateral membranes were incubated with S-adenosyl-L-[methyl-3H]methionine (0.3 mM) at 37 degrees C for 2 h at pH 9.0. This resulted in an increase in the specific activity of Na+ + K+-ATPase by 60%. Kinetic parameter analysis revealed a 2-fold increase in the Vmax. of this enzymatic activity, whereas the Km for ATP was unchanged. The methylation inhibitor S-adenosyl-L-homocysteine (2 mM) significantly reduced these S-adenosyl-L-methionine-stimulated increases in specific activity and the Vmax. of Na+ + K+-ATPase. S-Adenosyl-L-methionine treatment of basolateral membranes was also found to significantly increase the fluidity of these preparations, as assessed by steady-state fluorescence polarization techniques using the fluorophore 1,6-diphenyl-1,3,5-hexatriene; S-adenosyl-L-homocysteine (2 mM) again markedly reduced this S-adenosyl-L-methionine-induced increase in fluidity. While transmethylation reactions involving phospholipids, non-polar lipids and proteins were all found to exist in rat colonic basolateral membranes, based on a number of observations, the results of the present studies suggest that transmethylation of membrane phospholipids, but not membrane non-polar lipids or proteins, influenced the fluidity of basolateral membranes which, in turn, modified Na+ + K+-ATPase activity in these membranes.
Zinc Porphyrin Tweezer in Host-Guest Complexation: Determination of Absolute Configurations of Primary Monoamines by Circular Dichroism (2000)

A nonempirical method utilizing zinc porphyrin tweezers as chromophoric hosts for determining the absolute configuration of primary monoamines is described. A bidentate carrier was linked to the monoamines leading to conjugates capable of forming macrocyclic complexes with the porphyrin tweezer host (see scheme). The absolute stereochemistry of the monoamine can be determined from the sign of the circular dichroic couplet of the complexes.