gebhart/patrepeval huggingface dataset:
Affective gesture feedback instant messaging on handheld (2004)

Mobile devices and mobile networks are becoming more data-centric (evident in Japanese I-mode); even as mobile voice network average revenue per user is declining, new streams of data services are required which must take cognisance of handheld features such as their small screen area and input/output limitations. A text only instant messaging (IM) system, built on the Internet Engineering Task Force open standard session initiation protocol (SIP) and SIP for instant messaging and presence leveraging extensions (SIMPLE), has been developed in line with our novel introduction of a user-defined text hotkey feature. Given that text communication possesses expressive discourse with some presence level, we seek to show that one-click text-gesture fast-tracking enhances text communication further. For this study, we take a hybrid quantitative and qualitative approach. Initial results show that an affective gesture approach is more likely to improve IM chat spontaneity/response rate. Enhanced input mechanisms for handheld IM system are expected to increase co-presence between handheld users and their desktop-based counterparts while in a synchronous discussion.
Optimized spinning design for low PMD fibers: an analytical approach (2001)

It is known that the differential group delay (DGD) due to polarization mode dispersion (PMD) can be effectively reduced by spinning the fiber during drawing. In this paper, we propose an analytical approach that allows optimization of the spinning design. The fundamental idea is that, in the absence of polarization coupling, an optimized spinning profile can balance the effects of the intrinsic linear birefringence so that the differential group delay can be forced to be periodic and, consequently, have a limited amplitude as a function of distance. Our approach Is independent of the spin profile. In other words, with a fixed set of parameters that characterize a particular spin function, we are able to find analytically the values corresponding to a periodic DGD in a deterministic regime. Numerical results based on waveplate model confirm the analytical prediction and show that PMD can be reduced by about two orders of magnitude with respect to the same fiber without spinning, even after the introduction of random polarization coupling.
Information Geoscience in the Present and the Future (1986)

The research activities in the field of the information geoscience at my laboratory for the last 15 years have been introduced, and the future organizations and activities in geology proceeding for the 21st century are discussed in expectation. As the examples of the research activities at the present, the next five projects are introduced; (1) development of the geo-database system (GEODAS), (2) development of the geo-program package (GEOPAK), (3) application of computerized image processing for the fission track dating, (4) an example of the personal computer assisted instraction (CAI) system, and (5) design of an expert system for manupulation of GEODAS and GEOPAK.The state of the information geoscience in the future for the 21st century are discussed from the side of; (1) styles of the geological reports and papers, (2) research activities, (3) social activities, and (4) organization of geoscience.
Systematic Selection of Prognostic Features in Patients with Severe Head Injury (1980)

In this study small sets of clinical features were identified that, when combined, yield high quality predictions of long term outcome. The study is based on a series of 305 consecutive head-injured Dutch patients, all of whom had been in coma for at least 6 hours. The overall social outcome was assessed after 6 months using the Glasgow outcome scale. Predictions of outcome were made by assigning probabilities to each possible outcome category. The prognostically most promising features recorded during the early post-traumatic course were identified, and powerful combinations of prognostic features were selected on admission and 1, 3, 7, 14, and 28 days after the start of coma by an appropriate statistical method. At each time point, optimal prediction required sets of only three to five features, typically including age in decades, depth and duration of coma as assessed by the Glasgow coma scale, pupil reactivity to light, and spontaneous and reflex eye movements. The method described allows bedside predictions in individual patients and provides a tool for comparing the severity of injury between series of patients.
Universal personal telecommunications: concepts and requirements (1990)

A description is given of universal personal telecommunications (UPT), a network concept which will enable users to establish and receive calls on the basis of a single personal number (or identification) across multiple networks, from any arbitrary network entry point, with service access limited only by access or destination network and terminal capabilities. Although the concept of UPT is simple, there are many complex network mechanisms that need to be worked out to enable UPT to operate within and across networks and for multiple teleservices in an ISDN (integrated services digital network) environment. The authors discuss a range of network implications in relation to ISDN, mobile networks and intelligent networks. Data distribution options are presented, and aspects of No.7 signaling are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
STAT3 Signaling and the Hyper-IgE Syndrome (2007)

The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway has emerged over the past decade as a major relay between cell-surface receptors and cytokine responses. The human genome encodes four JAK family members — JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2) — and seven STAT proteins.1 JAKs are protein tyrosine kinases that interact with the intracellular domains of cytokine receptors (Figure 1) and that have enhanced catalytic activity toward substrate proteins after receptor activation. The primary JAK substrates are STAT proteins — latent transcription factors that require their tyrosine residues, and sometimes serine residues, to be . . .
A buffer store for data transmission (1962)

A method is presented for connecting an information source emitting data at an arbitrarily fluctuating rate to a synchronous transmission system. Expressions are derived relating the fluctuating input data rate and the maximum transmission efficiency to the capacity of a buffer store necessary to establish this connection.
Design of Algorithms for Payment Telematics Systems Evaluating Driver's Driving Style (2014)

This article and its issue fall into the area of payment telematics systems in the transportation domain, with specific focus on the evaluation of driver's driving style. The aim of the described research is a suggestion of an algorithmic method of the evaluation of the driving style of the driver for payment telematics systems. This, in its result, allows comprehensively to take into account the differences in drivers' behaviour and therefore also the probability rate of a traffic accident. The output of the algorithm is a projection of the evaluation into insurance payment. The article points out the weaknesses and shortcomings of the Pay As You Drive systems, which do not cover the behaviour of the driver and de facto only focus on the count of the driven kilometres.
Rules for peptide binding to MHC class II molecules (1994)

CD4+ T lymphocytes recognize peptide fragments of antigens that lie in the antigen binding pocket of class II major histocompatibility complex (MHC) molecules expressed on antigen-presenting cells. Specificity of T cells is determined by structural features of both the MHC molecule and antigenic peptide. MHC class II amino acid sequences are highly polymorphic within a population, and correlate with individual differences in response to infectious agents, vaccines, tumour antigens, and autoantigens. In the last few years several important breakthroughs and technological advances have made it possible to clarify the role of polymorphism and the molecular events in peptide interaction with major histocompatibility complex (MHC) class II proteins. The X-ray structural analysis of a MHC class II molecule together with the use of peptide libraries has permitted determination of the structural features of the complex between peptide antigen fragments and MHC class II proteins. The purpose of this article is to review our own studies and those of others on the requirements for peptide-class II molecule interaction and discuss possible implications for active immune intervention.
The High Temperature Deposition and Evaluation of Phosphorus‐ or Boron‐Doped Silicon Dioxide Films (1979)

Three different reactions for depositing phosphorus‐ or boron‐doped silicon dioxide at high temperatures have been investigated: the reaction of silane and phosphine or diborane with nitrous oxide at 700°–900°C; with nitric oxide at 700°–900°C; and with carbon dioxide and hydrogen at 900°C. The reactions with nitrous oxide are suitable for routine depositions on silicon‐integrated circuits. The reactions with nitric oxide are very sensitive to oxygen impurities which cause the film composition to vary. The reactions with carbon dioxide and hydrogen produce very little dopant in the film. The deposition rate and the film composition for the nitrous oxide reaction are satisfactorily explained by the Langmuir‐Hinshelwood model for heterogeneous reactions. The films from the nitrous oxide reactions have been evaluated by measuring the refractive index, etch rate, defect density, infrared spectra, step coverage, and diffusion properties. The major differences between these films and films deposited at lower temperatures are the lower etch rate, decreased defect density, and improved step coverage for the films deposited at high temperatures.
AT&T Ethernet transport services: metropolitan and long-haul transportservices (2002)

AT&T Ethernet transport services, including metropolitan Ethernet service and AT&T Ethernet private line service, are described. Part of AT&T’s Ethernet portfolio, the Ethernet transport services are based on Ethernet-over-SONET (synchronous optical network) architecture and offer private line service characteristics.
Reduced Storage, Quasi-Newton Trust Region Approaches to Function Optimization (1999)

In this paper we consider several algorithms for reducing the storage when using a quasi-Newton method in a dogleg--trust region setting for minimizing functions of many variables. Secant methods require O(n2) locations to store an approximate Hessian and O(n2) operations per iteration when minimizing a function of n variables. This storage requirement becomes impractical when n becomes large. Our algorithms use a BFGS update and require kn storage and $4kn + O(k2) operations per iteration, but they may require more iterations than the standard trust region techniques. Typically k is between 10 and 100. Our dogleg--trust region strategies involve expressions with matrix products with both the inverse of this Hessian and with the Hessian itself. Our techniques for updating expressions for the Hessian and its inverse can be used to improve the performance of line search, limited memory algorithms.
Management of object oriented development based on ranked use cases (2002)

While object orientation (OO) is advocated to give a better solution to most software engineering problems, management of OO software development itself seems to have not been firmly established yet. We extend the use of the case model to the development management of utilizing ranking information associated with each use case. This model provides strong traceability and improves the understanding of the software being developed and what the customer needs. Various measurements related to use cases can be used for progress management. The process and organizational hierarchy to establish and enhance frameworks is also proposed. Development processes which incorporate the use case model and the surrounding organizations and their roles are discussed. Case studies for mid sized, actual, real life projects were conducted and their results were favorable.
Robust speech recognition using near-field superdirective beamforming with post-filtering (2002)

This paper assesses the effectiveness of a microphone array system in providing robust hands-free speech recognition on a computer workstation. Near-field superdirectivity (NFSD) is used for the beamforming, and the effect of adding a post-filter is investigated. In the experiments, the speaker is located directly in front of the computer monitor at a distance of 60 cm and the array is designed to fit across the top of a standard 17 inch monitor. To test the proposed system, connected digit strings from the TIDIGITS database are used. The array is shown to have a marked effect on the recognition results in a high noise office environment, particularly where there is a high level of undesired speech.
Is there a link between adult neurogenesis and learning? (2006)

During the past several years, evidence has accumulated suggesting a relationship between newly born cells in the hippocampus and various types of learning and memory. However, most of the evidence is correlational and some of it does not agree. This review discusses both sides of this issue, considering the effects of learning on the production of new neurons in the dentate gyrus and the question of whether newly born cells participate in learning and memory.
Secure aircraft communications addressing and reporting system (ACARS) (2002)

With the increase in automation, airlines, military, and civil aviation organizations are relying on ACARS for air traffic and operational control. This paper proposes specific techniques to relieve ACARS frequency saturation using standard data compression algorithm. Additional solutions are provided to encrypt the ACARS protocol header without requiring any changes to the legacy ACARS equipment. The proposed Secure ACARS solutions will satisfy customer needs, improve the safety and reliability of the ACARS system and extend the usability of ACARS by conserving RF resources.
Introduction (1994)

This book is an introduction to using spreadsheets, or worksheets, as they are sometimes called, and illustrates the capabilities of several of the popular spreadsheet programs. It is not intended to replace the comprehensive manuals that are supplied with each spreadsheet program. Unfortunately, some of these manuals can be rather frightening for the newcomer and so this book provides a gentle lead-in to the full story provided by the manufacturers. Manuals are very useful if you know what you are looking for and if you want to know, for example, how to deal with copying, replicating, windowing and recalculation—always assuming you realise what these things are in the first place. This book provides an overview of the most common spreadsheet facilities and how they can help to improve and enhance the work that you process. In addition, it shows how spreadsheets can be used to solve a number of problems regularly encountered in statistics, mathematics, accounting and management. All spreadsheet programs will allow you to perform simple arithmetic operations, but some will offer a number of extremely sophisticated additional functions, some of which you may need desperately and some of which you may not find of value in your particular business.
Mobile documentation: Usability guidelines, and considerations for providing documentation on Kindle, tablets, and smartphones (2011)

With the growth of mobile devices outpacing that of desktop systems in 2011[1], mobile devices are the new PC. For example, as of July, 2011, 93% of U.S. consumers own mobile phones, 38% use smartphones, and a half-million Android devices are being activated every day worldwide [2, 3, 4]. The proliferation of applications for mobile devices means that users increasingly turn to smartphones and tablets to access products and services. They are also increasingly using mobile e-readers to read books. The New York Times Best Sellers list now includes e-books, and Amazon.com recently reported that it sells more e-books than hardcover and paperback combined [5]. In spite of these trends, usability for mobile applications lags far behind desktop systems, and the mobile user experience is often difficult and disappointing [6]. To alleviate this, mobile developers can take advantage of emerging mobile usability standards to increase user satisfaction. However, for technical communicators who provide mobile user assistance, there is comparatively little research on documentation for smartphones and tablets. This paper summarizes emerging mobile usability trends and suggests best practices for developing user assistance for mobile devices. It also shows how Oracle's Enterprise Performance Management (EPM) Information Development department delivered mobile documentation in online libraries. It concludes by suggesting a method for providing usable, single-sourced documentation files that can be read on e-readers as well as tablets, such as iPad and Xoom, and smartphones, such as iPhone and Android.
Use of proteomics to identify novel virulence determinants that are required for <i>Edwardsiella tarda</i> pathogenesis (2004)

Edwardsiella tarda is an important cause of haemorrhagic septicaemia in fish and also of gastro- and extraintestinal infections in humans. Using a combination of comparative proteomics and TnphoA mutagenesis, we have identified five proteins that may contribute to E. tarda PPD130/91 pathogenesis. Lowered protein secretion, impaired autoaggregation and the absence of six proteins were observed only in three highly attenuated mutants when cultured in Dulbecco's modified eagle medium (DMEM). Five out of six proteins could be identified by their mass spectra. Three proteins were identified as putative effector proteins (EseB, EseC and EseD) that are homologous to SseB, SseC and SseD of a type III secretion system (TTSS) in Salmonella species. The other two were EvpA and EvpC, homologous to Eip20 and Eip18 in Edwardsiella ictaluri. The complete sequencing and homology studies of evpA-H indicate that similar gene clusters are widely distributed in other pathogens such as Escherichia, Salmonella, Vibrio and Yersinia species with unknown functions. Insertional inactivation and deletion of evpB or evpC led to lower replication rates in gourami phagocytes, and reduced protein secretion and virulence in blue gourami. Complementation of these deletion mutants showed partial recovery in the above three phenotypes, indicating that these genes are vital for E. tarda pathogenesis. The transport of the EvpC protein may not use the TTSS in E. tarda. The expression of EvpA and EvpC as well as EseB, EseC and EseD was temperature dependent (suppressed at 37 degrees C), and disruption of esrB affected their expression. The present study identifies two possible secretion systems (TTSS and Evp) that are vital for E. tarda pathogenesis.
Ultimate boundedness control for uncertain discrete-time systems via set-induced Lyapunov functions (1994)

In this note, linear discrete-time systems affected by both parameter and input uncertainties are considered. The problem of the synthesis of a feedback control, assuring that the system state is ultimately bounded within a given compact set containing the origin with an assigned rate of convergence, is investigated. It is shown that the problem has a solution if and only if there exists a certain Lyapunov function which does not belong to a preassigned class of functions (e.g., the quadratic ones), but it is determined by the target set in which ultimate boundedness is desired. One of the advantages of this approach is that we may handle systems with control constraints. No matching assumptions are made. For systems with linearly constrained uncertainties, it is shown that such a function may be derived by numerically efficient algorithms involving polyhedral sets. The resulting compensator may be implemented as a linear variable-structure control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Diterpenoids (1988)

J. R. Hanson, Nat. Prod. Rep., 1988, 5, 211 DOI: 10.1039/NP9880500211
Synthesis and Biological Evaluation of a Novel Series of Heterobivalent Muscarinic Ligands Based on Xanomeline and 1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) (2014)

Novel bitopic hybrids, based on the M1/M4 muscarinic acetylcholine receptor (mAChR) orthosteric agonist xanomeline (1) and the putative M1 mAChR allosteric agonist 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1, 3) connected by an aliphatic linker of variable length, were prepared. The novel heterobivalent hybrids 4a-f along with the intermediate alcohols 5a-f were pharmacologically evaluated in radioligand binding assays and some of them for their functional efficacies in bioluminescence resonance energy transfer (BRET)-based assays to give an insight into the structure-activity relationships of bivalent and linker-attached compounds in mAChRs. The hybrid 4d exhibited high efficacy for β-arrestin2 engagement in M1 mAChR and alcohol 5c behaved much like 3 at M1 mAChR and showed full antagonism in both Gi activation and β-arrestin2 engagement at M4 mAChR. Moreover, docking simulations on the M1 mAChR model were performed to elucidate how the binding mode of the proposed compounds is influenced by the linker length.
High-Sensitivity Fiber Bragg Grating Temperature Sensor at High Temperature (2009)

A method of making full use of the durable strain which fiber Bragg grating (FBG) can undertake is presented, which hugely improves the sensitivities of FBG temperature sensors at high temperature. When a sensor is manufactured at room temperature, its FBG should be given a pre-relaxing length according to the temperature it is asked to measure; once the temperature rise to the asked one, its FBG starts to be stretched and it starts to work with high sensitivity. The relationship between the pre-relaxing length and the working temperature is analyzed. In experiments, when the pre-relaxing lengths are 0.2mm、0.5mm、0.6mm, the working temperatures rise 25℃、50℃、61℃, respectively, and the sensitivities are almost the same (675pm/℃). The facts that the experimental results agree well with the theoretical analyses verify this method’s validity.
Design of a predictive filter cache for energy savings in high performance processor architectures (2002)

Filter cache has been proposed as an energy saving architectural feature. A filter cache is placed between the CPU and the instruction cache (I-cache) to provide the instruction stream. Energy savings result from accesses to a small cache. There is however loss of performance when instructions are not found in the filter cache. The majority of the energy savings from the filter cache are due to the temporal reuse of instructions in small loops. We examine subsequent fetch addresses to predict whether the next fetch address is in the filter cache dynamically. In case a miss is predicted, we reduce miss penalty by accessing the I-cache directly. Experimental results show that our next fetch prediction reduces performance penalty by more than 91% and is more energy efficient than a conventional filter cache. Average I-cache energy savings of 31 % can be achieved by our filter cache design with around 1 % performance degradation.