gebhart/patrepeval huggingface dataset:
Application of Infrared Spectroscopy to Industrial Research (1941)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTApplication of Infrared Spectroscopy to Industrial ResearchNorman WrightCite this: Ind. Eng. Chem. Anal. Ed. 1941, 13, 1, 1–8Publication Date (Print):January 1, 1941Publication History Published online1 May 2002Published inissue 1 January 1941https://pubs.acs.org/doi/10.1021/i560089a001https://doi.org/10.1021/i560089a001research-articleACS PublicationsRequest reuse permissionsArticle Views641Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Aberrant adrenal sensitivity to multiple ligands in unilateral incidentaloma with subclinical autonomous cortisol hypersecretion: a prospective clinical study (2004)

Aberrant membrane receptors detected by in vivo stimulation tests appear to be common in autonomously functioning unilateral adrenocortical adenomas. These receptors may be involved in the modulation of cortisol secretion in adrenal incidentaloma, with potential therapeutic consequences for the control of subclinical cortisol hypersecretion.
Factor XII and uPAR upregulate neutrophil functions to influence wound healing (2018)

Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration, but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the inflammatory response. In 2 models of sterile inflammation, FXII-deficient mice (F12-/-) had fewer neutrophils recruited than WT mice. We discovered that neutrophils produced a pool of FXII that is functionally distinct from hepatic-derived FXII and contributes to neutrophil trafficking at sites of inflammation. FXII signals in neutrophils through urokinase plasminogen activator receptor-mediated (uPAR-mediated) Akt2 phosphorylation at S474 (pAktS474). Downstream of pAkt2S474, FXII stimulation of neutrophils upregulated surface expression of αMβ2 integrin, increased intracellular calcium, and promoted extracellular DNA release. The sum of these activities contributed to neutrophil cell adhesion, migration, and release of neutrophil extracellular traps in a process called NETosis. Decreased neutrophil signaling in F12-/- mice resulted in less inflammation and faster wound healing. Targeting hepatic F12 with siRNA did not affect neutrophil migration, whereas WT BM transplanted into F12-/- hosts was sufficient to correct the neutrophil migration defect in F12-/- mice and restore wound inflammation. Importantly, these activities were a zymogen FXII function and independent of FXIIa and contact activation, highlighting that FXII has a sophisticated role in vivo that has not been previously appreciated.
Polymeric schiff's base chelates and their precursors, 9. Synthesis of covalently and coordinatively bound polymeric chelates and their dioxygen binding in the solid state (1986)

Abstract Covalently bound polymeric cobalt chelates 5 of Co(salen) type were synthesized by copolymerization of 2‐hydroxy‐5‐vinylbenzaldehyde ( 2 ) with 4‐vinylpyridine and subsequent polymeranalogous reactions. Coordinatively bound polymeric chelates 6 were obtained from Co(salen) and poly(4‐vinylpyridine) or its copolymer with styrene. Dioxygen binding studies (volumetric measurements and ESR spectroscopy) revealed that mononuclear superoxo complexes are formed reversibly.
Stability of freeze-dried plasma prepared from patients on oral anticoagulants (1973)

The suitability of freeze-dried plasmas from patients on oral anticoagulants to serve as reference material in the calibration of thromboplastins used in the control of oral anticoagulant treatment was assessed in two centres. One pooled normal plasma and four pooled plasmas from patients at different levels of anticoagulation were collected into HEPES-citrate containing Trasylol. The plasmas, in 1 ml volumes, were freeze dried in siliconized ampoules under the optimal conditions used for biological standards. Small aliquots of the same plasmas were stored at -70 degrees C. Five different thromboplastins were used to carry out the tests on these plasmas. There was little difference in the clotting times obtained with five reference thromboplastins (two human, two rabbit, and one bovine reagent) on frozen and freeze-dried plasma, if the latter was tested immediately after complete reconstitution or within six hours of reconstitution if kept at +4 degrees C. Reconstituted plasmas showed a marked shortening of clotting times when stored at 22 and 37 degrees C if thromboplastins sensitive to activation of factor VII were used. In contrast, when thromboplastins sensitive to factor V were used, prothrombin times in plasmas stored at 22 and 37 degrees C became prolonged due to the loss of factor V.Freeze-dried plasmas from patients on oral anticoagulants can be used to calibrate thromboplastins, provided they are used immediately after complete reconstitution or kept at +4 degrees C for use within four to six hours of reconstitution.
Progression of human bone ingrowth into porous-coated implants: Rate of bone ingrowth in humans (1997)

We report the measured progression of human cancellous bone ingrowth into load-bearing porous-coated titanium implants over 5 time periods (0, 3, 6, 9, and 12 months). There was a statistically significant progression of bone ingrowth into the implants over a 9-month period, but the 9- and 12-month data were not different. Investigators are advised to analyze time "0" implants in order to distinguish mechanical impaction of bone from the biological process of bone ingrowth.
Sputtering Technology of Si Films for Low-Temperature Poly-Si TFTs (特集 液晶) (2001)

In this paper we discuss the development of sputter-Si technology for application in the area of poly-Si TFT Liquid Crystal Displays. We present the motivation behind this development and the state-of-the-art in materials and devices, based on PVD-Si precursor material. The Si- sputtering process is analyzed and data are presented on the quality of as-sputtered and post-annealed Si-films. The current drawbacks of Si sputtering are discussed, especially with respect to particles, film contamination and equipment availability. Based on the available data, strategies are presented to overcome these problems. PVD- Si technology has come a long way and has become a viable candidate as a Si-deposition method for next generation of poly-Si based applications. This technique is expected to play an even more important role, as the p-Si TFT-LCD industry moves to ultra-low temperature processing and, in parallel, the need increases for process cost reductions.
Production, transportation, and utilization of carbon-free hydrogen (2018)

Hydrogen is a potential secondary energy source having several advantageous characteristics compared with others. Moreover, the trend of decarbonisation of fossil fuels has significantly motivated the utilization of hydrogen to store and transport the energy. In this study, the routes of hydrogen production, storage, transportation, and utilization are analysed and compared. To achieve low cost of produce hydrogen, hydrogen production from low rank coal is assumed. For storage and transportation, three methods are analysed: liquid hydrogen, liquid organic hydrogen carrier using toluene-methylcyclohexane, and ammonia. In addition, in the utilization side, hydrogen is utilized mainly for power generation. The comparison of total energy efficiency for each scenario is performed. Ammonia with direct utilization, including combustion and fuel cell, is calculated to have the highest total energy efficiency and the lowest total cost.
Magnetostrictive Torque Sensors — Analysis of Performance Limits (1989)

<div class="htmlview paragraph">It is shown that the measured materials property of magnetostriction affects sensor output signal in two fundamentally different ways. The dual influence of magnetostriction on sensor output signal has heretofore not been reported.</div> <div class="htmlview paragraph">Five different methods of torque measurement signal detection are identified. For each of these detection methods, equations governing signal output are derived and are discussed. It is found that certain signal detection methods have both superior signal-to-noise performance and minimum sensitivity to variation of air gap. These detection methods are identified in the paper.</div> <div class="htmlview paragraph">Six sensor design configurations are analyzed. In the limit of miniature-size sensor design; performances of all signal detection methods are shown to deteriorate as a consequence of effects due to increased cross-leakage of flux between poles.</div>
Dysfunctional voiding confirmed by transdermal perineal electromyography, and its effective treatment with baclofen in women with lower urinary tract symptoms: a randomized double‐blind placebo‐controlled crossover trial (2007)

A 4-week course of baclofen significantly reduced the number of voids/24 h and increased the TL value in women with DV confirmed by transdermal perineal electromyography. These encouraging results suggest that baclofen could be used for treating DV in women.
Histamine, Histamine Receptors, and their Role in Immunomodulation: An Updated Systematic Review (2009)

Histamine, a biological amine, is considered as a principle mediator of many pathological processes regulating several essential events in allergies and autoimmune diseases. It stimulates different biological activities through differential expression of four types of histamine receptors (H1R, H2R, H3R and H4R) on secretion by effector cells (mast cells and basophils) through various immunological or non-immunological stimuli. Since H4R has been discovered very recently and there is paucity of comprehensive literature covering new histamine receptors, their antagonists/agonists, and role in immune regulation and immunomodulation, we tried to update the current aspects and fill the gap in existing literature. This review will highlight the biological and pharmacological characterization of histamine, histamine receptors, their antagonists/agonists, and implications in immune regulation and immunomodulation.
Extending Shelf‐Life of Fresh Wet Red Hake and Salmon Using CO <sub>2</sub> ‐O <sub>2</sub> Modified Atmosphere and Potassium Sorbate Ice at 1°C (1982)

ABSTRACT The ability to safely extend the shelf‐life of fish would open up the possibility of shipping fresh wet fish by boat. Red hake and salmon can be successfully held for almost 1 month and still be sensorally acceptable. A 60% carbon dioxide:20% oxygen:20% nitrogen‐modified atmosphere with a 1% potassium sorbate ice was most satisfactory. CO 2 did not lower the pH of the fish. Low temperature (1°C) and presence of both oxygen and potassium sorbate served as protection against botulism development. The presence of oxygen, even with salmon, did not lead to rancidity (TBA) problems. The Torrymeter can be used to monitor red hake quality. Work incorporating potassium sorbate dips before modified atmosphere storage with or without potassium sorbate ice is needed.
Prevention and Treatment of Pneumocystis Pneumonia (1992)

THE number of cases of Pneumocystis carinii pneumonia (PCP) recognized per year in the United States has increased dramatically, from about 65 in 1967 through 1970 to an estimated 20,000 to 60,000 in the late 1980s and early 1990s.1 , 2 This increase is largely due to the epidemic of the acquired immunodeficiency syndrome (AIDS); other contributing factors include increasing numbers of organ-transplant recipients, the use of more aggressive chemotherapy for malignant tumors and various other inflammatory or immunologic diseases, and improved diagnostic techniques.3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 The number of cases occurring annually in the United States may decline to some extent in the 1990s . . .
Image transmission over channels with bit errors and packet erasures (2002)

We consider a hybrid mixture of an image coder for bit error channels and an image coder for packet erasure channels. The first scheme uses rate-compatible punctured convolutional (RCPC)/cyclic redundancy code (CRC) concatenated channel coding with embedded zerotree wavelet source coding, while the second technique groups trees of wavelet coefficients into fixed-length packets that provide robustness against packet erasures. We demonstrate that the hybrid image coder outperforms either of the two building block methods on certain channels that suffer both packet losses and statistically varying bit errors.
Correction of Myopia With Er:YAG Laser Fundamental Mode Photorefractive Keratectomy (1995)

ABSTRACT BACKGROUND: Photorefractive keratectomy (PRK) has been performed with the ultraviolet 193 run radiation of the excimer laser. Due to its high absorption in water (3 µm water absorption band), the Er:YAG's 2.94 µm wavelength in the mid-infrared also qualifies for photoablation. METHODS: A new laser source, providing an output energy of 2.6 J (multimode) and 380 mJ in the fundamental mode, was used to perform corneal areal ablation (large) in two blind human eyes eccentrically. The fundamental mode provided a Gaussian-shaped beam profile, able to ablate more tissue centrally, depending on the fluence applied. RESULTS: The visible ablation diameter (opaque area) at the corneal surface was about 5 mm. Its effective ablation diameter was 4.85 ± 0.2 mm. The maximal ablation depth was 155 ± 5 µm. Surface roughness was 0.73 ± 0.06 µm, as assessed by a corneal silicone replica and subsequent confocal laser topometry. Intraoperatively, the ablation site turned opaque, clearing after a couple of minutes. The resultant surface was rough; epithelization was uneven but not delayed. Postoperative pain was reported to be minimal. Subepithelial reactions were comparable to a 3+ haze and showed bubble-like inclusions, which slowly disappeared. By week 4, the corneal surface was even; a 1+ subepithelium haze persisted in case 1, while a clear ablation site was seen in case 2. CONCLUSION: Areal corneal ablation with an Er:YAG laser that emits mid-infrared wavelengths seems possible. Although the thermally induced collateral damage is more pronounced, the wound healing pattern is comparable to 193 am PRK. This preliminary result has to be confirmed in normal eyes. [J Refract Surg. 1995;11:392-396.]
Alternative routing (2015)

Shortest path computation is a fundamental problem in road networks with application in various domains in research and industry. However, returning only the shortest path is often not satisfying; users are also interested in alternative paths which might be longer but have other advantages, e.g., less frequent traffic congestion. In this paper, we formally introduce the k-Shortest Paths with Limited Overlap (k-SPwLO) problem seeking to recommend k alternative paths which are (a) as short as possible and (b) sufficiently dissimilar based on a user-controlled similarity threshold. We propose two algorithms that examine the paths from a source s to a target t in increasing order of their length and progressively construct the result set. The baseline algorithm BSL builds upon a standard algorithm for computing k-Shortest Paths, followed by a filter step. The OnePass algorithm considers the overlap constraint in each expansion step while traversing the network. We evaluate the performance of both algorithms on real road networks and show that OnePass always outperforms BSL.
Co‐encapsulation of anti‐<i>BCR‐ABL</i> siRNA and imatinib mesylate in transferrin receptor‐targeted sterically stabilized liposomes for chronic myeloid leukemia treatment (2010)

Chronic myeloid leukemia (CML) is triggered by the BCR-ABL oncogene. Imatinib is the first-line treatment of CML; however imatinib resistance and intolerance have been detected in many patients. Therefore, new therapeutic approaches are required. The present work aimed at the development and application of transferrin receptor (TrfR) targeted liposomes co-encapsulating anti-BCR-ABL siRNA and imatinib at different molar ratios. The encapsulation yields and drug loading of each molecule was evaluated. Anti-leukemia activity of the developed formulations co-encapsulating siRNA and imatinib and of the combination of Trf-liposomes carrying siRNA and free imatinib under two different treatment schedules of pre-sensitization was assessed. The results obtained demonstrate that the presence of imatinib significantly decreases the encapsulation yields of siRNA, whereas imatinib encapsulation yields are increased by the presence of siRNA. Cytotoxicity assays demonstrate that the formulations co-encapsulating siRNA and imatinib promote a 3.84-fold reduction on the imatinib IC(50) (from 3.49 to 0.91 µM), whereas a 8.71-fold reduction was observed for the pre-sensitization protocols (from 42.7 to 4.9 nM). It was also observed that the formulations with higher siRNA to imatinib molar ratios promote higher cell toxicity. Thus, the present work describes a novel triple targeting strategy with one single system: cellular targeting (through the targeting ligand, transferrin) and molecular targeting at the BCR-ABL mRNA and Bcr-Abl protein level.
Query by Example Search on Speech at Mediaeval 2014. (2014)

In this paper, we describe the “Query by Example Search on Speech Task” (QUESST, formerly SWS, “Spoken Web Search”), held as part of the MediaEval 2014 evaluation campaign. As in previous years, the proposed task requires performing language-independent audio search in a low resource scenario. This year, the task has been designed to get as close as possible to a practical use case scenario, in which a user would like to retrieve, using speech, utterances containing a given word or short sentence, including those with limited inflectional variations of words, some filler content and/or word re-orderings.
Construction and Characterization of an Attenuated Purine Auxotroph in a<i>Francisella tularensis</i>Live Vaccine Strain (2006)

Francisella tularensis is a facultative intracellular pathogen and is the etiological agent of tularemia. It is capable of escaping from the phagosome, replicating to high numbers in the cytosol, and inducing apoptosis in macrophages of a variety of hosts. F. tularensis has received significant attention recently due to its potential use as a bioweapon. Currently, there is no licensed vaccine against F. tularensis, although a partially protective live vaccine strain (LVS) that is attenuated in humans but remains fully virulent for mice was previously developed. An F. tularensis LVS mutant deleted in the purMCD purine biosynthetic locus was constructed and partially characterized by using an allelic exchange strategy. The F. tularensis LVS delta purMCD mutant was auxotrophic for purines when grown in defined medium and exhibited significant attenuation in virulence when assayed in murine macrophages in vitro or in BALB/c mice. Growth and virulence defects were complemented by the addition of the purine precursor hypoxanthine or by introduction of purMCDN in trans. The F. tularensis LVS delta purMCD mutant escaped from the phagosome but failed to replicate in the cytosol or induce apoptotic and cytopathic responses in infected cells. Importantly, mice vaccinated with a low dose of the F. tularensis LVS delta purMCD mutant were fully protected against subsequent lethal challenge with the LVS parental strain. Collectively, these results suggest that F. tularensis mutants deleted in the purMCD biosynthetic locus exhibit characteristics that may warrant further investigation of their use as potential live vaccine candidates.
MetalPDB in 2018: a database of metal sites in biological macromolecular structures (2017)

MetalPDB (http://metalweb.cerm.unifi.it/) is a database providing information on metal-binding sites detected in the three-dimensional (3D) structures of biological macromolecules. MetalPDB represents such sites as 3D templates, called Minimal Functional Sites (MFSs), which describe the local environment around the metal(s) independently of the larger context of the macromolecular structure. The 2018 update of MetalPDB includes new contents and tools. A major extension is the inclusion of proteins whose structures do not contain metal ions although their sequences potentially contain a known MFS. In addition, MetalPDB now provides extensive statistical analyses addressing several aspects of general metal usage within the PDB, across protein families and in catalysis. Users can also query MetalPDB to extract statistical information on structural aspects associated with individual metals, such as preferred coordination geometries or aminoacidic environment. A further major improvement is the functional annotation of MFSs; the annotation is manually performed via a password-protected annotator interface. At present, ∼50% of all MFSs have such a functional annotation. Other noteworthy improvements are bulk query functionality, through the upload of a list of PDB identifiers, and ftp access to MetalPDB contents, allowing users to carry out in-depth analyses on their own computational infrastructure.
Robust Design of Cellular Materials With Topological and Dimensional Imperfections (2006)

A paradigm shift is underway in which the classical materials selection approach in engineering design is being replaced by the design of material structure and processing paths on a hierarchy of length scales for multifunctional performance requirements. In this paper, the focus is on designing mesoscopic material topology—the spatial arrangement of solid phases and voids on length scales larger than microstructures but smaller than the characteristic dimensions of an overall product. A robust topology design method is presented for designing materials on mesoscopic scales by topologically and parametrically tailoring them to achieve properties that are superior to those of standard or heuristic designs, customized for large-scale applications, and less sensitive to imperfections in the material. Imperfections are observed regularly in cellular material mesostructure and other classes of materials because of the stochastic influence of feasible processing paths. The robust topology design method allows us to consider these imperfections explicitly in a materials design process. As part of the method, guidelines are established for modeling dimensional and topological imperfections, such as tolerances and cracked cell walls, as deviations from intended material structure. Also, as part of the method, robust topology design problems are formulated as compromise Decision Support Problems, and local Taylor-series approximations and strategic experimentation techniques are established for evaluating the impact of dimensional and topological imperfections, respectively, on material properties. Key aspects of the approach are demonstrated by designing ordered, prismatic cellular materials with customized elastic properties that are robust to dimensional tolerances and topological imperfections.
Cerebral Steal during Hypercapnia and the Inverse Reaction during Hypocapnia Observed by the<sup>133</sup>Xenon Technique in Man (1968)

(1968). Cerebral Steal during Hypercapnia and the Inverse Reaction during Hypocapnia Observed by the 133Xenon Technique in Man. Scandinavian Journal of Clinical and Laboratory Investigation: Vol. 21, No. sup102, pp. XIII-D-XIII-D.