gebhart/patrepeval huggingface dataset:
Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non‐myeloablative regimen and CD154 blockade (2002)

The aim of the present study was to assess the survival of adult porcine islets transplanted into baboons receiving either (I) conventional triple drug immunosuppressive therapy or (2) a non-myeloablative regimen and an anti-CD154 monoclonal antibody (mAb) aimed at tolerance-induction. Group 1 baboons (n = 3) were pancreatectomized prior to intraportal injection of 10,000 porcine islet equivalents (IE)/kg and immunosuppressed with anti-thymocyte globulin (ATG), cyclosporine and azathioprine. In Group 2 (n = 2), non-pancreatectomized baboons underwent induction therapy with whole body and thymic irradiation, and ATG. Extracorporeal immunoadsorption (EIA) of anti-Galalpha1,3Gal (Gal) antibody was carried out. Maintenance therapy was with cobra venom factor, cyclosporine. mycophenolate mofetil, methylprednisolone and anti-CD154 mAb. Porcine islets were injected intraportally (14,000 and 32,000 IE/kg, respectively) and high-dose pig mobilized peripheral blood progenitor cells (3 x 10(10) cells/kg) were infused into a systemic vein. Porcine islets were also implanted in the sternomastoid muscle to facilitate subsequent biopsies. In both groups. porcine C-peptide was measured, and histological examination of liver or sternomastoid muscle biopsies was performed at regular intervals. In Group 1, total pancreatectomy reduccd human C-peptide to < 0.1 ng/ml and induced insulin-requiring diabetes. The transplantation of porcine islets was followed by normalization of glycemia for 15-24 h. Porcine C-peptide was detected only transiently immediately after porcine islet injection (maximum 0.12 ng/ml). Histological examination of liver biopsies taken between days 2 and 19 did not reveal viable islets, but necrotic cell structures with mononuclear cell infiltrates were identified in portal venules. In Group 2, injection of porcine islets into non-pancreatectomized recipients induced a transient hypoglycemia (2-4 h) requiring concentrated intravenous dextrose administration. Porcine C-peptide was detectable for 5 and 3 days (maximum 2.8 and 1.0 ng/ml), respectively. Baboon #4 died on day 12 from small bowel intussusception. Liver and sternomastoid muscle biopsies showed well-preserved porcine islets, staining positive for insulin and glucacon, without signs of rejection. In baboon #5, viable islets were detected in the sternomastoid muscle biopsy on day 14, but not on day 28 or thereafter. A progressive mononuclear cell and macrophage infiltration was seen in the biopsies. In conclusion, conventional immunosuppression allowed survival of porcine islets in baboons for < 24 h. The non-myeloablative regimen prolonged survival of porcine islets for > 14 days. However, despite depletion of T cells, anti-Gal antibody and complement, and CD154-hlockade, porcine islets were rejected by day 28. These results suggest that powerful innate immune responses are involved in rejection of discordant xenogencic islets.
Robust Speech Dereverberation Using Multichannel Blind Deconvolution With Spectral Subtraction (2007)

A robust dereverberation method is presented for speech enhancement in a situation requiring adaptation where a speaker shifts his/her head under reverberant conditions causing the impulse responses to change frequently. We combine correlation-based blind deconvolution with modified spectral subtraction to improve the quality of inverse-filtered speech degraded by the estimation error of inverse filters obtained in practice. Our method computes inverse filters by using the correlation matrix between input signals that can be observed without measuring room impulse responses. Inverse filtering reduces early reflection, which has most of the power of the reverberation, and then, spectral subtraction suppresses the tail of the inverse-filtered reverberation. The performance of our method in adaptation is demonstrated by experiments using measured room impulse responses. The subjective results indicated that this method provides superior speech quality to each of the individual methods: blind deconvolution and spectral subtraction.
Clinical, Histologic, and Cell Kinetic Discriminants Between Lamellar Ichthyosis and Nonbullous Congenital Ichthyosiform Erythroderma (1985)

Patients described as having lamellar ichthyosis (LI) may not all have the same disorder. We studied nine patients, four of whom had erythroderma and generalized fine scaling, while the remainder had more marked scaling and hyperkeratosis without erythema. The former group is referred to as having nonbullous congenital ichthyosiform erythroderma (CIE), and the other is said to have LI. The clinical differences were paralleled by cell kinetic and histologic differences. The mean tritiated thymidine autoradiographic labeling indices were 9.36 +/- 4.05 and 19.70 +/- 5.84 for the LI and CIE groups, respectively. The histologic differences were delineated using 10-cm analogue scales and showed statistically significant differences for hyperkeratosis and parakeratosis. These data support the hypothesis that LI and CIE are separate disorders.
Smoking and life expectancy among HIV-infected individuals on antiretroviral therapy in Europe and North America (2014)

Well treated HIV-infected individuals may lose more life years through smoking than through HIV. Excess mortality associated with smoking increases markedly with age. Therefore, increases in smoking-related mortality can be expected as the treated HIV-infected population ages. Interventions for smoking cessation should be prioritized.
EKLF and KLF2 have compensatory roles in embryonic β-globin gene expression and primitive erythropoiesis (2007)

The Krüppel-like C2/H2 zinc finger transcription factors (KLFs) control development and differentiation. Erythroid Krüppel-like factor (EKLF or KLF1) regulates adult beta-globin gene expression and is necessary for normal definitive erythropoiesis. KLF2 is required for normal embryonic Ey- and betah1-, but not adult betaglobin, gene expression in mice. Both EKLF and KLF2 play roles in primitive erythroid cell development. To investigate potential interactions between these genes, EKLF/KLF2 double-mutant embryos were analyzed. EKLF(-/-)KLF2(-/-) mice appear anemic at embryonic day 10.5 (E10.5) and die before E11.5, whereas single-knockout EKLF(-/-) or KLF2(-/-) embryos are grossly normal at E10.5 and die later than EKLF(-/-)KLF2(-/-) embryos. At E10.5, Ey- and betah1-globin mRNA is greatly reduced in EKLF(-/-)KLF2(-/-), compared with EKLF(-/-) or KLF2(-/-) embryos, consistent with the observed anemia. Light and electron microscopic analyses of E9.5 EKLF(-/-)KLF2(-/-) yolk sacs, and cytospins, indicate that erythroid and endothelial cells are morphologically more abnormal than in either single knockout. EKLF(-/-)KLF2(-/-) erythroid cells are markedly irregularly shaped, suggesting membrane abnormalities. EKLF and KLF2 may have coordinate roles in a common progenitor to erythroid and endothelial cells. The data indicate that EKLF and KLF2 have redundant functions in embryonic beta-like globin gene expression, primitive erythropoiesis, and endothelial development.
A generic computer simulation model to characterize photolithography manufacturing area in an IC FAB facility (1991)

The technique used to develop a generic simulation model to characterize the photolithography manufacturing area in a semiconductor FAB facility is discussed. Use of simulation to study the impact of policy decisions on key manufacturing system parameters like product cycle time, line throughput, work-in-progress inventory, and utilizations are discussed. Details of the structured modeling approach taken to develop reusable simulation models are also discussed. The simulation model was successfully validated and the results presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Exact Solutions and Conservation Laws of a Two-Dimensional Integrable Generalization of the Kaup-Kupershmidt Equation (2013)

We study a two-dimensional integrable generalization of the Kaup-Kupershmidt equation, which arises in various problems in mathematical physics. Exact solutions are obtained using the Lie symmetry method in conjunction with the extended tanh method and the extended Jacobi elliptic function method. In addition to exact solutions we also present conservation laws which are derived using the multiplier approach.
RECENT PROGRESS IN LOW-VOLTAGE FIELD-EMISSION CATHODE DEVELOPMENT (1984)

Recent progress in field emission cathode array development has yielded current densities greater than 100 A/cm2.
Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals (2018)

Solid dosage forms of biopharmaceuticals such as therapeutic proteins could provide enhanced bioavailability, improved storage stability, as well as expanded alternatives to parenteral administration. Although numerous drying methods have been used for preparing dried protein powders, choosing a suitable drying technique remains a challenge. In this review, the most frequent drying methods, such as freeze drying, spray drying, spray freeze drying, and supercritical fluid drying, for improving the stability and bioavailability of therapeutic proteins, are discussed. These technologies can prepare protein formulations for different applications as they produce particles with different sizes and morphologies. Proper drying methods are chosen, and the critical process parameters are optimized based on the proposed route of drug administration and the required pharmacokinetics. In an optimized drying procedure, the screening of formulations according to their protein properties is performed to prepare a stable protein formulation for various delivery systems, including pulmonary, nasal, and sustained-release applications.
Tissue kallikrein and kinin infusion promotes neovascularization in limb ischemia (2008)

Adenovirus-mediated kallikrein delivery has been shown to promote blood vessel growth in the limb under both ischemic and normoperfused conditions. Here we investigated whether a continuous supply of kallikrein and kinin peptide can induce neovascularization in a rat model of hindlimb ischemia. Rats underwent femoral artery ligation and localized injection of tissue kallikrein, bradykinin or B1 receptor agonist, followed by infusion of proteins by osmotic minipump. Regional blood flow was monitored weekly by laser Doppler perfusion imaging. Three weeks after surgery, rats receiving kallikrein and kinins showed a significant increase in the perfusion ratio of ischemic vs. normoperfused limb compared to control rats. Similarly, a microsphere assay showed that kallikrein and kinins significantly increased regional blood flow without altering blood pressure. Moreover, kallikrein and kinins significantly augmented capillary and arteriole densities, as quantified by immunostaining with CD-31 and smooth muscle alpha-actin. Both tissue kallikrein and bradykinin increased hemoglobin content in Matrigel implants in mice, providing further evidence of the angiogenic properties. Kinins, when delivered subcutaneously via Matrigel in rats, also increased regional perfusion. This is the first demonstration that local application of tissue kallikrein protein or kinin peptide has therapeutic value in the treatment of ischemic disease by promoting neovascularization.
A Novel Synthetic Sealant to Treat Air Leaks at Cardiac Reoperation (2001)

This novel synthetic sealant prevents postoperative air leaks in the majority of patients suffering lung injury at cardiac reoperation.
Oocyte Scoring Enhances Embryo-Scoring in Predicting Pregnancy Chances with IVF Where It Counts Most (2015)

Oocyte-scoring, thus, provides useful clinical information especially in good prognosis patients with large numbers of high quality embryos. This finding appears of particular importance at a time when many IVF centers are committing sizable investments to closed incubation systems with time-lapse photography, which are exclusively meant to define embryo morphology.
Las cuentas del imperio español en América, entrevista por Alberto Cue (1996)

.
X-band all-waveguide radial combiner for high power applications (2015)

The development of a 12-way X-band all-waveguide radial divider/combiner is presented. The radial combiner is comprised of three parts: a center feed, a radial line, and peripheral waveguide ports. The center feed is comprised of two sections: a rectangular waveguide section and a mode transducer section. The latter is a circular waveguide fed by four-way in-phase combiner to convert the rectangular waveguide TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sub> mode to a TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sub> circular waveguide mode for in-phase feeding of all peripheral ports. For design evaluation, the 12-way combiner was built and tested but also two back-to-back test fixtures, one for the mode transducer and the second for the radial combiner were fabricated and tested as well. The measured insertion loss and phase imbalance of the combiner over a 10% operating bandwidth are less than 0.35 dB and ±5°, respectively. The structure is suitable for high power and should handle few kilowatts.
Gazing with pEYEs (2008)

Various interfaces for gaze control (which are recommended due to certain requirements of controlling a machine by gaze) have already been developed. One problem, especially for novice users, is that respective interfaces all look different and require different steps to use. As a means to unify interfaces for gaze control, pie menus are suggested. Such pEYEs allow for universal input in various applications usable by novices and by experts. We present two examples for pEYE interfaces; one eye-typing application and one desktop navigation. Observations in user studies indicate effective and efficient performance and a large acceptance.
Caracterização química e metalográfica dos aços inoxidáveis de implantes removidos de pacientes (2011)

OBJETIVO: Este trabalho estudou a composição química e metalográfica (microestrutura, tamanho de grão, teor de inclusões) de aços inoxidáveis austeníticos, desenvolvidos para aplicações como biomateriais, utilizados na fabricação de implantes ortopédicos. MÉTODO: Foram analisados doze implantes removidos de pacientes afetados por quadro inflamatório. As análises químicas foram desenvolvidas pelas técnicas Espectrometria de Emissão Ótica e Microanálise por Dispersão de Energia (EDS) e o tamanho de grão foi determinado por microscopia ótica e Microscopia Eletrônica de Varredura (MEV) conforme norma ASTM E 1382 97. RESULTADOS: Observou-se que, todos os implantes apresentavam tamanho de grão superior ao recomendado pela norma, constatou-se também a presença de ferrita delta em dez dos doze implantes removidos, que de acordo com a norma ASTM F138-92 não deveriam ser percebidas microscopicamente com um aumento de 100 vezes. CONCLUSÕES: Em oito casos existe forte indicação de que as inflamações foram desencadeadas pela corrosão por pite. Nivel de Evidência III, Revisão sistemática de Estudos .
Autonomic Blocking Agents. II. Alkamine Esters and their Quaternaries (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAutonomic Blocking Agents. II. Alkamine Esters and their QuaternariesJ. W. Cusic and Richard A. RobinsonCite this: J. Org. Chem. 1951, 16, 12, 1921–1930Publication Date (Print):December 1, 1951Publication History Published online1 May 2002Published inissue 1 December 1951https://pubs.acs.org/doi/10.1021/jo50006a015https://doi.org/10.1021/jo50006a015research-articleACS PublicationsRequest reuse permissionsArticle Views100Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plasmonic nanoshell functionalized etched fiber Bragg gratings for highly sensitive refractive index measurements (2015)

A novel fiber optical refractive index sensor based on gold nanoshells immobilized on the surface of an etched single-mode fiber including a Bragg grating is demonstrated. The nanoparticle coating induces refractive index dependent waveguide losses, because of the variation of the evanescently guided part of the light. Hence the amplitude of the Bragg reflection is highly sensitive to refractive index changes of the surrounding medium. The nanoshell functionalized fiber optical refractive index sensor works in reflectance mode, is suitable for chemical and biochemical sensing, and shows an intensity dependency of 4400% per refractive index unit in the refractive index range between 1.333 and 1.346. Furthermore, the physical length of the sensor is smaller than 3 mm with a diameter of 6 μm, and therefore offers the possibility of a localized refractive index measurement.
Future ate for system on a chip... some perspectives (2004)

Flexibility – Tester FOR the Chip: If you can’t measure it, you can’t improve it. And, the measurement challenges are getting harder and diverging between characterization/production, wafer/final, digital/mixed signal. Yet, the real world ATE solution must address this entire measurement envelope, on as few platforms as possible. ATE solutions must provide inter-platform correlation (e.g. different configurations) to enable leverage and investment protection while maintaining consistent software environment for unified program development. ‘Infinite’ applications, one interface. One platform, ‘infinite’ measurement capabilities.
Advancements in MR Imaging of the Prostate: From Diagnosis to Interventions (2011)

Prostate cancer is the most frequently diagnosed cancer in males and the second leading cause of cancer-related death in men. Assessment of prostate cancer can be divided into detection, localization, and staging; accurate assessment is a prerequisite for optimal clinical management and therapy selection. Magnetic resonance (MR) imaging has been shown to be of particular help in localization and staging of prostate cancer. Traditional prostate MR imaging has been based on morphologic imaging with standard T1-weighted and T2-weighted sequences, which has limited accuracy. Recent advances include additional functional and physiologic MR imaging techniques (diffusion-weighted imaging, MR spectroscopy, and perfusion imaging), which allow extension of the obtainable information beyond anatomic assessment. Multiparametric MR imaging provides the highest accuracy in diagnosis and staging of prostate cancer. In addition, improvements in MR imaging hardware and software (3-T vs 1.5-T imaging) continue to improve spatial and temporal resolution and the signal-to-noise ratio of MR imaging examinations. Another recent advancement in the field is MR imaging guidance for targeted prostate biopsy, which is an alternative to the current standard of transrectal ultrasonography-guided systematic biopsy.
Processing and Assessment of Spectrometric, Stereoscopic Imagery Collected Using a Lightweight UAV Spectral Camera for Precision Agriculture (2013)

Imaging using lightweight, unmanned airborne vehicles (UAVs) is one of the most rapidly developing fields in remote sensing technology. The new, tunable, Fabry-Perot interferometer-based (FPI) spectral camera, which weighs less than 700 g, makes it possible to collect spectrometric image blocks with stereoscopic overlaps using light-weight UAV platforms. This new technology is highly relevant, because it opens up new possibilities for measuring and monitoring the environment, which is becoming increasingly important for many environmental challenges. Our objectives were to investigate the processing and use of this new type of image data in precision agriculture. We developed the entire processing chain from raw images up to georeferenced reflectance images, digital surface models and biomass estimates. The processing integrates photogrammetric and quantitative remote sensing approaches. We carried out an empirical assessment using FPI spectral imagery collected at an agricultural wheat test site in the summer of 2012. Poor weather conditions during the campaign complicated the data processing, but this is one of the challenges that are faced in operational applications. The results indicated that the camera performed consistently and that the data processing was consistent, as well. During the agricultural experiments, promising results were obtained for biomass estimation when the spectral data was used and when an appropriate radiometric correction was applied to the data. Our results showed that the new FPI technology has a great potential in precision agriculture and indicated many possible future research topics.
Δ<sup>9</sup>‐tetrahydrocannabinol increases endogenous extracellular glutamate levels in primary cultures of rat cerebral cortex neurons: Involvement of CB<sub>1</sub> receptors (2002)

The effects of the principal psychoactive component of marijuana, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), on endogenous extracellular glutamate levels in primary cultures of rat cerebral cortex neurons were investigated. Locally applied Delta(9)-THC (0.03, 3, 300, and 1,000 nM) concentration-dependently increased basal extracellular glutamate levels (+18% +/- 11%, +54% +/- 10%, +90% +/- 14%, +149% +/- 33% vs. basal). The facilitatory effects of Delta(9)-THC (3 and 300 nM) on cortical glutamate were fully counteracted in the presence of the selective CB(1) receptor antagonist SR141716A (10 nM) and by replacement of the normal Krebs-Ringer bicarbonate buffer with a low-Ca(2+) (0.2 mM) medium. Delta(9)-THC application also induced an enhancement in K(+)-evoked glutamate levels. These findings suggest that an increase in cortical glutamatergic transmission mediated by local CB(1) receptor activation may underlie some of the psychoactive and behavioral effects of acute marijuana consumption.
Subjective study on compressed asymmetric stereoscopic video (2010)

Asymmetric stereoscopic video coding takes advantage of the binocular suppression of the human vision by representing one of the views with a lower quality. This paper describes a subjective quality test with asymmetric stereoscopic video. Different options for achieving compressed mixed-quality and mixed-resolution asymmetric stereo video were studied and compared to symmetric stereo video. The bitstreams for different coding arrangements were simulcast-coded according to the Advanced Video Coding (H.264/AVC) standard. The results showed that in most cases, resolution-asymmetric stereo video with the downsampling ratio of 1/2 along both coordinate axes provided similar quality as symmetric and quality-asymmetric full-resolution stereo video. These results were achieved under same bitrate constrain while the processing complexity decreased considerably. Moreover, in all test cases, the symmetric and mixed-quality full-resolution stereoscopic video bitstreams resulted in a similar quality at the same bitrates.