gebhart/patrepeval huggingface dataset:
Cytosolic double-stranded RNA-dependent protein kinase is likely a dimer of partially phosphorylated Mr = 66,000 subunits. (1992)

The work described in this report suggests the existence of two biochemically distinguishable forms of the interferon-inducible, double-stranded RNA-dependent protein kinase. Kinase isolated from the cytosolic fraction (S-100) and the ribosome salt wash fraction of interferon-treated cells differed in their chromatographic properties. S-100 kinase eluted from a gel filtration column with M(r) = 140,000-160,000 and was predominantly anionic in nature, whereas ribosomal kinase eluted with M(r) = 66,000 and was predominantly cationic in nature. Purified preparations of S-100 kinase contained the M(r) = 66,000 subunit, P1, as the only polypeptide present in stoichiometric amounts, and thus the S-100 kinase appears to be a dimer of P1 subunits. Dimerization of the S-100 kinase was dependent on the phosphorylation state of the enzyme. Kinase isolated from S-100 was partially phosphorylated. Dephosphorylation of the S-100 kinase by treatment with alkaline phosphatase resulted in a monomeric form of the enzyme with biochemical characteristics similar to that of the ribosome salt wash kinase.
The Power spectrum of Pulse-Position Modulation With Dead Time and Pulse Jitter (1998)

Pulse-position modulation (PPM) is considered to be an efficient modulation format for transmitting information over optical communication channels, requiring only the delay of a single optical pulse in each word to convey the desired information. In this aricle, the power spectral density (PSD) of a random pulse train generated by a sequence of PPM symbols is derived. Variations of laser intensity, pulse jitter, and “dead time” are taken into account in the model. Results show that the PSD of the generalized PPM signal is composed of both discrete and continuous components.
Transliteration of proper names in cross-lingual information retrieval (2003)

We address the problem of transliterating English names using Chinese orthography in support of cross-lingual speech and text processing applications. We demonstrate the application of statistical machine translation techniques to "translate" the phonemic representation of an English name, obtained by using an automatic text-to-speech system, to a sequence of initials and finals, commonly used sub-word units of pronunciation for Chinese. We then use another statistical translation model to map the initial/final sequence to Chinese characters. We also present an evaluation of this module in retrieval of Mandarin spoken documents from the TDT corpus using English text queries.
Human injuries following jellyfish stings. (1992)

There are approximately 500,000 jellyfish stings every year in the Chesapeake Bay. Dr. Burnett describes the mechanism of jellyfish stings, venom components, types of reactions, diagnosis, and therapy.
FRACTALS IN PATHOLOGY (1997)

Many natural objects, including most objects studied in pathology, have complex structural characteristics and the complexity of their structures, for example the degree of branching of vessels or the irregularity of a tumour boundary, remains at a constant level over a wide range of magnifications. These structures also have patterns that repeat themselves at different magnifications, a property known as scaling self-similarity. This has important implications for measurement of parameters such as length and area, since Euclidean measurements of these may be invalid. The fractal system of geometry overcomes the limitations of the Euclidean geometry for such objects and measurement of the fractal dimension gives an index of their space-filling properties. The fractal dimension may be measured using image analysis systems and the box-counting, divider (perimeter-stepping) and pixel dilation methods have all been described in the published literature. Fractal analysis has found applications in the detection of coding of coding regions in DNA and measurement of the space-filling properties of tumours, blood vessels and neurones. Fractal concepts have also been usefully incorporated into models of biological processes, including epithelial cell growth, blood vessel growth, periodontal disease and viral infections.
ECG Spectrum Analysis Predicts Return of Spontaneous Circulation following Prolonged Ventricular Fibrillation (1993)

Purpose: To determine the utility of electrocardiogram (ECG) spectrum analysis in predicting the return of spontaneous circulation (ROSC) in a swine model of out-of-hospital cardiac arrest. Methods: This was a prospective experimental trial, conducted in an animal laboratory, using 10 mixed-breed domestic swine of either gender (weighing 19.0 to 23.7 kgs). Animals were sedated, intubated, anesthetized, and instrumented for monitoring of arterial and central venous pressures, and ECG. Ventricular fibrillation (VF) was induced using a bipolar pacing catheter, and was untreated for eight minutes. Following eight minutes of no-flow, advanced cardiac life support (ACLS) was begun. ECG was amplified with the HP Model 881 ID ECG/HIS Conditioner with a bandpass filter of 0.5-30hz. A 12bit A/D converter and Wave Master II visual wave editor were used to sample at a frequency of 500 Hz. Spectrum analysis applied Fast Fourier Transformation with 2K bits of sampling points. Frequency and amplitude were measured at the maximum amplitude points.
Lessons learned from DNA repair defective syndromes (2007)

Genomic instability is the driving force behind cancer development. Human syndromes with DNA repair deficiencies comprise unique opportunities to study the clinical consequences of faulty genome maintenance leading to premature aging and premature cancer development. These syndromes include chromosomal breakage syndromes with defects in DNA damage signal transduction and double-strand break repair, mismatch repair defective syndromes as well as nucleotide excision repair defective syndromes. The same genes that are severely affected in these model diseases may harbour more subtle variations in the 'healthy' normal population leading to genomic instability, cancer development, and accelerated aging at later stages of life. Thus, studying those syndromes and the molecular mechanisms behind can significantly contribute to our understanding of (skin) cancerogenesis as well as to the development of novel individualized preventive and therapeutic anticancer strategies. The establishment of centers of excellence for studying rare genetic model diseases may be helpful in this direction.
Set theory and logic (1963)

Set Theory and Logic is the result of a course of lectures for advanced undergraduates, developed at Oberlin College for the purpose of introducing students to the conceptual foundations of mathematics. Mathematics, specifically the real number system, is approached as a unity whose operations can be logically ordered through axioms. One of the most complex and essential of modern mathematical innovations, the theory of sets (crucial to quantum mechanics and other sciences), is introduced in a most careful concept manner, aiming for the maximum in clarity and stimulation for further study in
High-purity, monodisperse TiO2 powders by hydrolysis of titanium tetratethoxide. 2. Aqueous interfacial electrochemistry and dispersion stability (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh-purity, monodisperse TiO2 powders by hydrolysis of titanium tetratethoxide. 2. Aqueous interfacial electrochemistry and dispersion stabilityEric A. Barringer and H. Kent BowenCite this: Langmuir 1985, 1, 4, 420–428Publication Date (Print):July 1, 1985Publication History Published online1 May 2002Published inissue 1 July 1985https://pubs.acs.org/doi/10.1021/la00064a006https://doi.org/10.1021/la00064a006research-articleACS PublicationsRequest reuse permissionsArticle Views920Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Arenavirus Nucleoprotein Targets Interferon Regulatory Factor-Activating Kinase IKKε (2012)

Arenaviruses perturb innate antiviral defense by blocking induction of type I interferon (IFN) production. Accordingly, the arenavirus nucleoprotein (NP) was shown to block activation and nuclear translocation of interferon regulatory factor 3 (IRF3) in response to virus infection. Here, we sought to identify cellular factors involved in innate antiviral signaling targeted by arenavirus NP. Consistent with previous studies, infection with the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) prevented phosphorylation of IRF3 in response to infection with Sendai virus, a strong inducer of the retinoic acid-inducible gene I (RIG-I)/mitochondrial antiviral signaling (MAVS) pathway of innate antiviral signaling. Using a combination of coimmunoprecipitation and confocal microscopy, we found that LCMV NP associates with the IκB kinase (IKK)-related kinase IKKε but that, rather unexpectedly, LCMV NP did not bind to the closely related TANK-binding kinase 1 (TBK-1). The NP-IKKε interaction was highly conserved among arenaviruses from different clades. In LCMV-infected cells, IKKε colocalized with NP but not with MAVS located on the outer membrane of mitochondria. LCMV NP bound the kinase domain (KD) of IKKε (IKBKE) and blocked its autocatalytic activity and its ability to phosphorylate IRF3, without undergoing phosphorylation. Together, our data identify IKKε as a novel target of arenavirus NP. Engagement of NP seems to sequester IKKε in an inactive complex. Considering the important functions of IKKε in innate antiviral immunity and other cellular processes, the NP-IKKε interaction likely plays a crucial role in arenavirus-host interaction.
Soft margin estimation with various separation levels for LVCSR (2008)

We continue our previous work on soft margin estimation (SME) to large vocabulary continuous speech recognition (LVCSR) in two new aspects. The first is to formulate SME with different unit separation. SME methods focusing on string-, word-, and phone-level separation are defined. The second is to compare SME with all the popular conventional discriminative training (DT) methods, including maximum mutual information estimation (MMIE), minimum classification error (MCE), and minimum word/phone error (MWE/MPE). Tested on the 5k-word Wall Street Journal task, all the SME methods achieves a relative word error rate (WER) reduction from 17% to 25% over our baseline. Among them, phone-level SME obtains the best performance. Its performance is slightly better than that of MPE, and much better than those of other conventional DT methods. With the comprehensive comparison with conventional DT methods, SME demonstrates its success on LVCSR tasks.
Software defined radio receivers exploiting noise cancelling: A tutorial review (2014)

Traditional radio receivers were narrowband and dedicated to a single frequency band exploiting LC tanks, whereas software defined radios target a flexibly programmable frequency. The broadband noise cancelling circuit technique has proven useful to achieve this target, as it breaks the traditional trade-off between low noise and broadband impedance matching. Different variants exist, with noise cancellation in the voltage or current domain, either at RF or after frequency translation to baseband. This article reviews the development of the noise cancelling technique and its role in inductorless interference robust software defined radio receivers.
Intronic Single Nucleotide Polymorphisms in the<i>RET</i>Protooncogene Are Associated with a Subset of Apparently Sporadic Pheochromocytoma and May Modulate Age of Onset (2003)

Approximately 75% of pheochromocytomas are sporadic. Germline mutations in RET, VHL, SDHB, and SDHD have been shown to cause the 25% that are hereditary. Germline high penetrance gain-of-function RET mutations cause multiple endocrine neoplasia type 2, of which medullary thyroid carcinoma (MTC) and pheochromocytoma are components, whereas loss-of-function mutations cause Hirschprung disease (HSCR). A low-penetrance founder locus, in linkage disequilibrium with a RET ancestral haplotype comprising specific alleles at three intron (IVS) 1 single nucleotide polymorphisms (SNPs) (haplotype 0) and SNP A45A, predisposes to the majority of isolated HSCR. A different low-penetrance locus, in linkage disequilibrium with IVS 1 haplotype 2 and SNP S836S, was associated with a subset of sporadic MTC. We, therefore, sought to determine whether RET might also be a low-penetrance gene for apparently sporadic pheochromocytoma. We analyzed 104 pheochromocytoma cases without germline mutations in RET, VHL, SDHD, and SDHB for their status at A45, S836, three IVS 1 SNPs, and a novel upstream insertion/deletion variant. Pheochromocytoma cases were not associated with either A45A or S836S, but we found that cases were associated with haplotype 0 (P = 0.032). However, unlike HSCR, this pheochromocytoma-associated haplotype 0 was not associated with A45A. Taken together with the strengthening of association with the addition of the 5' insertion/deletion variant data (P = 0.016), our observations suggest the presence of a low-penetrance pheochromocytoma susceptibility locus in a region upstream of the putative loci for HSCR and apparently sporadic MTC.
Flow through Porous Media-the Ergun Equation Revisited (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlow through Porous Media-the Ergun Equation RevisitedI. F. Macdonald, M. S. El-Sayed, K. Mow, and F. A. L. DullienCite this: Ind. Eng. Chem. Fundamen. 1979, 18, 3, 199–208Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/i160071a001https://doi.org/10.1021/i160071a001research-articleACS PublicationsRequest reuse permissionsArticle Views7325Altmetric-Citations804LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Altered Neuronal Intrinsic Properties and Reduced Synaptic Transmission of the Rat's Medial Geniculate Body in Salicylate-Induced Tinnitus (2012)

Sodium salicylate (NaSal), an aspirin metabolite, can cause tinnitus in animals and human subjects. To explore neural mechanisms underlying salicylate-induced tinnitus, we examined effects of NaSal on neural activities of the medial geniculate body (MGB), an auditory thalamic nucleus that provides the primary and immediate inputs to the auditory cortex, by using the whole-cell patch-clamp recording technique in MGB slices. Rats treated with NaSal (350 mg/kg) showed tinnitus-like behavior as revealed by the gap prepulse inhibition of acoustic startle (GPIAS) paradigm. NaSal (1.4 mM) decreased the membrane input resistance, hyperpolarized the resting membrane potential, suppressed current-evoked firing, changed the action potential, and depressed rebound depolarization in MGB neurons. NaSal also reduced the excitatory and inhibitory postsynaptic response in the MGB evoked by stimulating the brachium of the inferior colliculus. Our results demonstrate that NaSal alters neuronal intrinsic properties and reduces the synaptic transmission of the MGB, which may cause abnormal thalamic outputs to the auditory cortex and contribute to NaSal-induced tinnitus.
An engineered avian-origin influenza A virus for pancreatic ductal adenocarcinoma virotherapy (2016)

Pancreatic ductal adenocarcinoma (PDA) is one of the leading causes of cancer-related deaths worldwide and the development of new treatment strategies for PDA patients is of crucial importance. Virotherapy uses natural or engineered oncolytic viruses (OVs) to selectively kill tumour cells. Due to their genetic heterogeneity, PDA cells are highly variable in their permissiveness to various OVs. The avian influenza A virus (IAV) H7N3 A/turkey/Italy/2962/03 is a potent inducer of apoptosis in PDA cells previously shown to be resistant to other OVs (Kasloff et al., 2014), suggesting that it might be effective against specific subclasses of pancreatic cancer. To improve the selectivity of the avian influenza isolate for PDA cells, here confirmed deficient for IFN response, we engineered a truncation in the NS1 gene that is the major virus-encoded IFN antagonist. The recombinant virus (NS1-77) replicated efficiently in PDA cells, but was attenuated in non-malignant pancreatic ductal cells, in which it induced a potent IFN response that acted upon bystander uninfected cancer cells, triggering their death. The engineered virus displayed an enhanced ability to debulk a PDA-derived tumour in xenograft mouse model. Our results highlight the possibility of selecting an IAV strain from the diverse natural avian reservoir on the basis of its inherent oncolytic potency in specific PDA subclasses and, through engineering, improve its safety, selectivity and debulking activity for cancer treatment.
Inhibitory Action of Gossypol on Enzymes and Growth of <i>Trypanosoma cruzi</i> (1982)

Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide-linked enzymes (alpha-hydroxyacid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.
Ferene-S as the chromogen for serum iron determinations (1983)

Ferene-S was tested as the iron chromogen and the results were compared with the chromogen Ferrozine. With Ferene-S the volume of serum could be halved. We also tried to adapt Ferene-S in total iron binding capacity determinations but failed. From the interfering substances in serum iron determination the effects of bilirubin, copper and zinc were tested. Bilirubin was not observed to have any effect on iron values with Ferene-S or Ferrozine as chromogens. Copper ions had a distinct additive effect with both chromogens, but it could be eliminated by the addition of thiourea to the solutions. Zinc had no effect.
Hybrid Buck–Boost Feedforward and Reduced Average Inductor Current Techniques in Fast Line Transient and High-Efficiency Buck–Boost Converter (2009)

This paper presents a buck-boost converter with high efficiency and small output ripple to extend the battery life of portable devices. Besides, the hybrid buck-boost feedforward (HBBFF) technique is integrated in this converter to achieve fast line response. The new control topology minimizes the switching and conduction losses at the same time even when four switches are used. Therefore, over a wide input voltage range, the proposed buck-boost converter with minimum switching loss like the buck or boost converter can reduce the conduction loss through the use of the reduced average inductor current (RAIC) technique. Moreover, the HBBFF technique minimizes the voltage variation at the output of error amplifier. Consequently, a fast line transient response can be achieved with small dropout voltage at the output. Especially, the converter can offer good line and load regulations to ensure a regulated output voltage without being affected by the decreasing battery voltage. Experimental results show that the output voltage is regulated over a wide battery lifetime, and the output ripple is minimized during mode transition. The peak efficiency is 97% and the transient dropout voltage can be improved substantially.
Real-Time, Full 3-D Reconstruction of Moving Foreground Objects From Multiple Consumer Depth Cameras (2012)

The problem of robust, realistic and especially fast 3-D reconstruction of objects, although extensively studied, is still a challenging research task. Most of the state-of-the-art approaches that target real-time applications, such as immersive reality, address mainly the problem of synthesizing intermediate views for given view-points, rather than generating a single complete 3-D surface. In this paper, we present a multiple-Kinect capturing system and a novel methodology for the creation of accurate, realistic, full 3-D reconstructions of moving foreground objects, e.g., humans, to be exploited in real-time applications. The proposed method generates multiple textured meshes from multiple RGB-Depth streams, applies a coarse-to-fine registration algorithm and finally merges the separate meshes into a single 3-D surface. Although the Kinect sensor has attracted the attention of many researchers and home enthusiasts and has already appeared in many applications over the Internet, none of the already presented works can produce full 3-D models of moving objects from multiple Kinect streams in real-time. We present the capturing setup, the methodology for its calibration and the details of the proposed algorithm for real-time fusion of multiple meshes. The presented experimental results verify the effectiveness of the approach with respect to the 3-D reconstruction quality, as well as the achieved frame rates.