gebhart/patrepeval huggingface dataset:
Effect of Surface Nanotopography on Immunoaffinity Cell Capture in Microfluidic Devices (2011)

Immunoaffinity microfluidic devices have recently become a popular choice to isolate specific cells for many applications. To increase cell capture efficiency, several groups have employed capture beds with nanotopography. However, no systematic study has been performed to quantitatively correlate surface nanopatterns with immunoaffinity cell immobilization. In this work, we controlled substrate topography by depositing close-packed arrays of silica nanobeads with uniform diameters ranging from 100 to 1150 nm onto flat glass. These surfaces were functionalized with a specific antibody and assembled as the base in microfluidic channels, which were then used to capture CD4+ T cells under continuous flow. It is observed that capture efficiency generally increases with nanoparticle size under low flow rate. At higher flow rates, cell capture efficiency becomes increasingly complex; it initially increases with the bead size then gradually decreases. Surprisingly, capture yield plummets atop depositions of some particle diameters. These dips likely stem from dynamic interactions between nanostructures on the substrate and cell membrane as indicated by roughness-insensitive cell capture after glutaraldehyde fixing. This systematic study of surface nanotopography and cell capture efficiency will help optimize the physical properties of microfluidic capture beds for cell isolation from biological fluids.
Effects of doped dialkylazobenzenes on helical pitch of cholesteric liquid crystal with medium molecular weight: utilisation for full-colour image recording (2001)

The effects of small amounts of achiral photochromic dopants, 4,4′-di-n-alkylazobenzenes, with various lengths of substituted alkyl chain (CnH2n + 1 ∶ n = 4, 7, 11, 12, 13, 14, 15, 16) on the helical pitch of a cholesteric liquid crystal (CLC) with ca. 1000 molecular weight were investigated in order to utilise the cholesteric reflected colour of these combinations for a rewritable colour image recording. The (E)-azobenzenes (~2 wt%) in the host CLC induced pitch changes dependent on temperature, the concentration of the azobenzenes and the length of substituted alkyl chain on the azobenzenes. In the low region of the cholesteric temperature (below 100 °C), some (E)-azobenzenes remarkably lengthened the pitch. Contrary to this, upon irradiation, E–Z photoisomerization of all the azobenzenes in the CLC phase induced consecutive pitch shortenings in response to the formation of the Z isomers. The changed pitch (reflected colour) could be fixed in cholesteric glassy solids. In the glassy solid state, the photo and thermal isomerization of the azobenzenes could not influence the cholesteric pitch any longer, therefore, the colour was stably stored. However, since the molecular arrangement of the CLC and the conformation of the doped azobenzenes completely returned to the initial state upon re-heating to isotropic temperatures, the stored colour could be easily erased. Based on these fundamental investigations, it is suggested that the mixed systems of the medium-molecular-weight CLCs and the 4,4′-dialkylazobenzenes will be effective materials for a rewritable full-colour image recording in a photon mode.
Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon. (1986)

We show that the cytotoxins tumor necrosis factor (TNF) or lymphotoxin (LT), at concentrations of approximately 10(-11) M induce monocytic differentiation of human myeloid cell lines. After 5 d of culture in the presence of rTNF and LT, a significant proportion of the myeloid cell lines express monocyte differentiation antigens and ANAE activity, and become able to reduce nitroblue tetrazolium (NBT) and mediate low levels of ADCC against tumor target cells. These markers of differentiation, however, are maximally induced when rIFN-gamma, at concentrations as low as 4 U/ml, is present simultaneously with the cytotoxins, and the two classes of cytokines act synergistically to induce terminal differentiation. The appearance of monocytic antigens is accompanied by acquisition of morphology and other functional properties of mature monocytic cells, such as chemiluminescence and phagocytosis, and by expression of FcR for monomeric IgG. A decrease in cell proliferation accompanies induced differentiation, and is not due to the cytotoxic properties of TNF or LT, as indicated in simultaneous analysis of surface phenotype and cell cycle. The lack of cytotoxicity of TNF on the HL-60 cell line is also demonstrated by the enhancing effect of TNF on HL-60 cell growth and nucleoside uptake in the first 2 d of culture. These data show that the cytotoxins TNF and LT mediate complex effects on cells of the myelomonocytic lineage and, in synergy with IFN-gamma, can fully induce immature myeloid cells to differentiate into cells with phenotypic, functional, and proliferative characteristics of terminally differentiated myelomonocytic cells.
Are Bulk Defective Carbon Nanotubes Less Electrically Conducting? (2003)

Current−voltage measurements of various carbon nanotube−polymer composite films at room temperature as well as at liquid nitrogen temperature reveal that the composite films consisting of defective carbon nanotubes exhibit higher conductivity than do graphite carbon nanotubes. This novel finding contradicts previous results.
Three-Dimensional Hierarchical Plasmonic Nano-Architecture Enhanced Surface-Enhanced Raman Scattering Immunosensor for Cancer Biomarker Detection in Blood Plasma (2013)

A three-dimensional (3D) hierarchical plasmonic nano-architecture has been designed for a sensitive surface-enhanced Raman scattering (SERS) immunosensor for protein biomarker detection. The capture antibody molecules are immobilized on a plasmonic gold triangle nanoarray pattern. On the other hand, the detection antibody molecules are linked to the gold nanostar@Raman reporter@silica sandwich nanoparticles. When protein biomarkers are present, the sandwich nanoparticles are captured over the gold triangle nanoarray, forming a confined 3D plasmonic field, leading to the enhanced electromagnetic field in intensity and in 3D space. As a result, the Raman reporter molecules are exposed to a high density of "hot spots", which amplifies the Raman signal remarkably, improving the sensitivity of the SERS immunosensor. This SERS immunosensor exhibits a wide linear range (0.1 pg/mL to 10 ng/mL) and a low limit of detection (7 fg/mL) toward human immunoglobulin G protein in the buffer solution. This biosensor has been successfully used for detection of the vascular endothelial growth factor in the human blood plasma from clinical breast cancer patient samples.
Adaptive memory system over ethernet (2010)

For cloud computing, computer infrastructures need to be scaled up adaptively. However, their local memories cannot be expanded beyond the amount loaded to each computer. We present a method for scaling up of memory system beyond its local memory's capacity by high-speed page swapping using an adaptively attached solid-state disk (SSD) to a computer. Our PCI Express (PCIe) technology, ExpEther (Express Ether), interconnects a computer and a PCIe-based SSD via a standard Ethernet. The data transfer between the local memory of the computer and the SSD is performed without slow TCP/IP but with PCIe-standard direct memory access (DMA). It achieves IOPS of 33-K read and 36-K write for an access of 4-KB page size, which is twice as good as that for iSCSI with TCP-offloading. With the proposed method, a computer which only has 2-GB local physical memory can sustain its performance even when a 10-GB in-memory database is loaded.
Heterostructured Ceramic Powders for Photocatalytic Hydrogen Production: Nanostructured <scp> <scp>TiO</scp> </scp> <sub>2</sub> Shells Surrounding Microcrystalline ( <scp> <scp>Ba</scp> </scp> , <scp> <scp>Sr</scp> </scp> ) <scp> <scp>TiO</scp> </scp> <sub>3</sub> Cores (2012)

Heterostructured photocatalysts were prepared to have nanostructured ( ns ) TiO 2 shells surrounding microcrystalline ( mc ) cores of ( Ba , Sr ) TiO 3 . The as‐prepared heterostructures were annealed between 400°C and 600°C to improve crystallinity and core‐shell interfacial bonding. X‐ray diffraction, electron microscopy, and gas adsorption measurements demonstrated that 50 nm thick shells composed of nanocrystalline and nanoporous TiO 2 surrounded mc ‐cores such that the heterostructured particles had surface areas of 50–100 m 2 /g. The mc ‐( Ba , Sr ) TiO 3 / ns ‐ TiO 2 core‐shell photocatalysts annealed at 600°C had slightly reduced surface areas, but had the highest rates of photochemical hydrogen production from water/methanol solutions, rates much greater than those for ns ‐ TiO 2 or mc ‐( Ba , Sr ) TiO 3 alone. Such heterostructured powders represent a new strategy for the design of efficient photocatalysts and the use of nanostructured catalytic coatings.
Gate drive circuit for zero-voltage-switching half- and full-bridge converters (2002)

Resonant techniques like zero-voltage switch (ZVS) and zero-current switch (ZCS) are widely applied to raise the switching frequency and efficiency of converters. An important subclass of converters using resonant techniques, is formed by ZVS half- and full-bridge converters. While different varieties of this subclass of converters have been reported, the gate drive circuit is seldom described. In this paper a new gate drive circuit applicable in ZVS half- and full-bridge converters is proposed. The circuit shows excellent features such as transformer isolation, no ringing of the gate-source voltage of the switches, programmable dead-time, no active components beside one low-side driver, insensitivity to component value variation, negative gate-source voltage at switch-off and low drive power. Moreover the circuit can be used in variable frequency applications. The theoretical results obtained, are verified by experiments.
온라인 게임중독과 청소년범죄의 관계 (2006)

청소년들은 가정 또는 인터넷 게임방에서 온라인 게임에 몰입한다. 그리고 그들은 게임중독의 증세를 보이기도 하는데, 현실과 가상의 세계를 구분할 수 없는 상태에 이르러 폭행을 저지르고, 심지어 살인에 이르는 경우를 우리는 언론의 보도를 종종 접할 수 있다. 이는 청소년의 게임중독이 범죄에까지 영향을 미칠 수 있다는...
Stereoregularity in heterogeneous Ziegler-Natta catalysis (1962)

P. Cossee, Trans. Faraday Soc., 1962, 58, 1226 DOI: 10.1039/TF9625801226
An API to Wi-Fi Direct Using Reactive Building Blocks (2012)

Implementing unfamiliar functionalities in smartphone applications can be a difficult and a tedious task. Owing to the fact that the API do not have a formal way of representing the sequence of events may be one reason. This thesis describes the development process of various Arctis building blocks based on Android's API of Wi-Fi Direct. The objective of these blocks was to simplify the implementation of Wi-Fi Direct by confining a predictable sequence of events.An Android application was developed in order to test the functionalities, and to validate the prospects of portability for the various building blocks. The work resulted in a construction of three main building blocks, where each of them is responsible for a Wi-Fi Direct related function. Developers will be able to seamlessly utilize the Wi-Fi Direct functionality by combining and implementing these building blocks into their own applications.
Augmented reality assisted photo positioning for mobile devices (2013)

Recent developments in mobile techniques have enabled a great variety of Location Based Services (LBS). A high positioning accuracy is a fundamental requirement for precision LBS applications, e.g., precise LBS marketing in shopping malls or indoor emergency evacuation services with mobile devices. However, most offerable commercial positioning systems, such as GPS/GNSS and RF-based systems, can not provide positioning accuracy within one meter. In this work, a new positioning approach is proposed for mobile devices, Called Photo Positioning, it can provide a high accuracy positioning service. The “positioning” here means to find the location where a photo was taken by investigating the geometric relations between the images of points of interest (POI) in the photo and their location in the real world based on the principle of photo imaging. To implement a photo positioning system, three major components are needed, including a POI database, a method to recognize and locate POIs in a photo and an algorithm to calculate the position where the photo was taken from the POI information. A positioning algorithm based on the geometric similarity in photo imaging is presented in this work, and a prototype system is developed for Android smartphone platforms. Our experimental results shows that the average positioning error of the proposed photo positioning approach can be as low as 74.34 cm.
Enzyme-Catalyzed Enantioselective Diaryl Ketone Reductions (2006)

The synthesis of diarylmethanols via the reduction of a range of substituted benzophenone and benzoylpyridine derivatives with ketoreductase enzymes (KREDs) has afforded chiral products with high yield (>90%) and ee (up to >99%). Ortho, meta, and para substitutions with a variety of electron-donating, electron-withdrawing, and halogen groups were examined. Substitution at the ortho position and/or highly electronically dissymmetric molecules were not required for good selectivity, as is the case with conventional chemical catalyst reductions. [reaction: see text].
One Pot Synthesis of Pyrrolo[2,3-<i>b</i>]pyridine Derivatives (1994)

Abstract Pyrrolo[2,3-b]pyridine derivatives, precursors of chiral NADH models, are prepared by a facile one pot procedure.
Broadband and High Extinction Ratio Mode Converter Using the Tapered Hybrid Plasmonic Waveguide (2019)

We propose and numerically analyze a broadband and high extinction ratio mode converter to achieve the mode conversion between the fundamental transverse electric mode (TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ) and the first-order transverse magnetic mode (TM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> ). The mode converter is achieved by using the tapered hybrid plasmonic waveguide which the metal is directly covered on the Si waveguide without a thin low-index layer. After optimizing the structure of the tapered hybrid plasmonic waveguide, a wide operation bandwidth of 100 nm is obtained with the extinction ratio of the TM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> mode and TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> mode larger than 20 dB in the output Si waveguide for the forward propagation. And for the back propagation, the operation bandwidth over 65 nm is obtained with the extinction ratio larger than 20 dB in the output Si waveguide. The whole footprint of the mode converter is only 0.8 × 11 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Fabrication tolerance analysis is also demonstrated.
A Model of Intrusion Prevention Base on Immune (2009)

The theory of modern immunology provides a novel idea to study network intrusion detection and defence system. Inspired information processing in biology immune system is a highly parallel and distributed intelligent computation which has learning, memory, and associative retrieval capabilities. The architecture of multi-agent in depth defence based on immune principle is proposed. The agents of intrusion detection detect all intrusion which passes by the agent, including known and unknown. The information of new intrusion, which gotten from current monitored network is encapsulated and sent to the other network as vaccine by mobile agents. So the other network can prevent the same intrusion. Intrusion packets are prevented from gateway of intrusion source by response agent. The experimental results show that the new model actualizes an active and distributed prevention policy than that of the traditional passive intrusion prevention systems.
Recent Development of Flax Fibres and Their Reinforced Composites Based on Different Polymeric Matrices (2013)

This work describes flax fibre reinforced polymeric composites with recent developments. The properties of flax fibres, as well as advanced fibre treatments such as mercerization, silane treatment, acylation, peroxide treatment and coatings for the enhancement of flax/matrix incompatibility are presented. The characteristic properties and characterizations of flax composites on various polymers including polypropylene (PP) and polylactic acid, epoxy, bio-epoxy and bio-phenolic resin are discussed. A brief overview is also given on the recent nanotechnology applied in flax composites.
Internal tandem duplication of <i>fms</i>‐like tyrosine kinase 3 is associated with poor outcome in patients with myelodysplastic syndrome (2004)

The results of the current study demonstrate that FLT3/ITD is associated with a high risk of transformation to AML, rapid progression of AML, and poor survival in patients with MDS.
PROGRESSIVE FAMILIAL MYOCLONIC EPILEPSY IN THREE FAMILIES: ITS CLINICAL FEATURES AND PATHOLOGICAL BASIS: AN APPENDIX ON THE GENETIC ASPECTS (1955)

Journal Article PROGRESSIVE FAMILIAL MYOCLONIC EPILEPSY IN THREE FAMILIES: ITS CLINICAL FEATURES AND PATHOLOGICAL BASIS: AN APPENDIX ON THE GENETIC ASPECTS Get access D. G. F. HARRIMAN, D. G. F. HARRIMAN Department of Neurology, the Royal Victoria HospitalBelfast, the Institute of Pathology, Queen's UniversityBelfast, and the Department of Neuropathology, The School of MedicineLeeds Search for other works by this author on: Oxford Academic PubMed Google Scholar J. H. D. MILLAR, J. H. D. MILLAR Department of Neurology, the Royal Victoria HospitalBelfast, the Institute of Pathology, Queen's UniversityBelfast, and the Department of Neuropathology, The School of MedicineLeeds Search for other works by this author on: Oxford Academic PubMed Google Scholar A. C. STEVENSON A. C. STEVENSON Department of Neurology, the Royal Victoria HospitalBelfast, the Institute of Pathology, Queen's UniversityBelfast, and the Department of Neuropathology, The School of MedicineLeeds Search for other works by this author on: Oxford Academic PubMed Google Scholar Brain, Volume 78, Issue 3, September 1955, Pages 325–349, https://doi.org/10.1093/brain/78.3.325 Published: 01 September 1955
Catalytic Asymmetric Michael Reaction of β-Keto Esters:  Effects of the Linker Heteroatom in Linked-BINOL (2003)

We describe the development of a general catalytic asymmetric Michael reaction of acyclic beta-keto esters to cyclic enones, in which asymmetric induction occurs at the beta-position of the acceptors. Among the various asymmetric catalyst systems examined, the newly developed La-NR-linked-BINOL complexes (R = H or Me) afforded the best results in terms of reactivity and selectivity. In general, the NMe ligand 2 was suitable for the combination of small enones and small beta-keto esters, and the NH ligand 1 was suitable for bulkier substrates (steric tuning of the catalyst). Using the La-NMe-linked-BINOL complex, the Michael reaction of methyl acetoacetate (8a) to 2-cyclohexen-1-one (7b) gave the corresponding Michael adduct 9ba in 82% yield and 92% ee. The linker heteroatom in linked-BINOL is crucial for achieving high reactivity and selectivity in the Michael reaction of beta-keto esters. The amine moiety in the NR-linked-BINOL can also tune the Lewis acidity of the central metal (electronic tuning of the catalyst), which was supported by density functional studies and experimental results. Another advantage of the NR-linked-BINOL ligand as compared with O-linked-BINOL is the ease of modifying a substituent on the amine moiety, making it possible to synthesize a variety of NR-linked-BINOL ligands for further improvement or development of new asymmetric catalyses by introducing additional functionality on the linker with the amine moiety. The efficiency of the present asymmetric catalysis was demonstrated by the synthesis of the key intermediate of (-)-tubifolidine and (-)-19,20-dihydroakuammicine in only five steps compared to the nine steps required by the original process from the Michael product of malonate. This strategy is much more atom economical. On the basis of the results of mechanistic studies, we propose that a beta-keto ester serves as a ligand as well as a substrate and at least one beta-keto ester should be included in the active catalyst complex. Further improvement of the reaction by maintaining an appropriate ratio of the La-NMe-linked-BINOL complex and beta-keto esters is also described.
A 12-GHz silicon bipolar dual-conversion receiver for digital satellite applications (2005)

A 12-GHz monolithic silicon bipolar receiver for digital video broadcasting via satellite (DVB-S) is presented. The receiver is based on a dual-conversion superheterodyne architecture that employs a single LO integrated in the same die. To comply with the stringent LO phase noise requirement of -101 dBc/Hz at 100 kHz offset from the carrier, an innovative VCO topology, based on a three-layer monolithic transformer, was used. The VCO exhibits a phase noise of -102 dBc/Hz at 100 kHz offset from a 5.3-GHz carrier and a 1.1-GHz tuning range. At 12 GHz, the conversion gain is 33.6 dB, the single-sideband noise figure is 5.9 dB and the output IP3 is +16 dBm. This work reports the first 12-GHz DVB-S monolithic receiver integrated in a low-cost silicon bipolar technology.
Annual Legal Update (2012)

claims, holding that all of plaintiff's statements cited in his application for promotion were made pursuant to his official duties and therefore enjoyed no First
Single-Spin Magnetometry with Multipulse Sensing Sequences (2011)

We experimentally demonstrate single-spin magnetometry with multipulse sensing sequences. The use of multipulse sequences can greatly increase the sensing time per measurement shot, resulting in enhanced ac magnetic field sensitivity. We theoretically derive and experimentally verify the optimal number of sensing cycles, for which the effects of decoherence and increased sensing time are balanced. We perform these experiments for oscillating magnetic fields with fixed phase as well as for fields with random phase. Finally, by varying the phase and frequency of the ac magnetic field, we measure the full frequency-filtering characteristics of different multipulse schemes and discuss their use in magnetometry applications.
Present status of volatile ruthenium in analytical chemistry and health physics. (1986)

核分裂によって生じる放射性白金族元素の中で生成量の最も多いRuは多くの原子価をとり,化学的性質が複雑なばかりでなく,8価の酸化物まで作って揮発するため,関連する研究や産業上の難問になっていた。近年はRuの複雑な化学的性質を触媒等に利用しようとする基礎研究が盛んであるが,原子力分野でも燃料再処理のダウンストリームを中心に,この困難克服のための研究が活発に行われるようになっている。本稿では,放射性Ruの研究の展望と揮発性Ruの基本的性質を基礎にして,近年の分離分析への応用環境試料分析における揮散,生体での挙動と被曝線量評価の問題点について述べる。
Touchscreen field specification for public access database queries: let your fingers do the walking (1990)

Database query is becoming a common task in public access systems; touchscreens can provide an appealing interface for such a system. This paper explores three interfaces for constructing queries on alphabetic field values with a touchscreen interface; including a QWERTY keyboard, an Alphabetic keyboard, and a Reduced Input Data Entry (RIDE) interface. The RIDE interface allows field values to be entered with fewer “keystrokes” (touches) than either keyboard while eliminating certain errors. In one test database, the RIDE interface required 69% fewer keystrokes than either keyboard interface.