gebhart/patrepeval huggingface dataset:
Food intake regulation in rodents: Y<sub>5</sub>or Y<sub>1</sub>NPY receptors or both? (2000)

Neuropeptide Y (NPY), one of the most abundant peptides in rat and human brains, appears to act in the hypothalamus to stimulate feeding. It was first suggested that the NPY Y 1 receptor (Y 1 R) was involved in feeding stimulated by NPY. More recently a novel NPY receptor subtype (Y 5 R) was identified in rat and human as the NPY feeding receptor subtype. There is, however, no absolute consensus since selective Y 1 R antagonists also antagonize NPY-induced hyperphagia. Nevertheless, new anti-obesity drugs may emerge from further pharmacological characterization of the NPY receptors and their antagonists. A large panel of Y 1 R and Y 5 R antagonists (such as CGP71683A, BIBO3304, BIBP3226, 1229U91, and SYNAPTIC and BANYU derivatives but also patentable in-house-synthesized compounds) have been evaluated through in vitro and in vivo tests in an attempt to establish a predictive relationship between the binding selectivity for human receptors, the potency in isolated organs assays, and the inhibitory effect on food intake in both normal and obese hyperphagic rodents. Although these results do not allow one to conclude on the implication of a single receptor subtype at the molecular level, this approach is crucial for the design of novel NPY receptor antagonists with potential use as anti-obesity drugs and for evaluation of their possible adverse peripheral side effects, such as hypotension.Key words: obesity, weight reduction, food intake, neuropeptide Y, rodents.
FORWARD AND BACKWARD CHAIN-CODE REPRESENTATION FOR MOTION PLANNING OF CARS (2004)

The path-planning problem is presented to show a car of any desired shape moving from a starting position to a destination in a finite space with arbitrarily shaped obstacles in it. In this paper, a new chain-code representation is developed to record the motion path when forward and backward movements are allowed. By placing the smooth turning-angle constraint, we can obtain more realistic results to the actual motion of cars. Meanwhile, by combining rotational mathematical morphology and distance transformation, we can obtain the shortest collision-free path. As soon as the distance map and the collision-free codes have been established offline, the shortest paths of cars starting from any location toward the destination can be promptly obtained online. Experimental results show that our algorithm works successfully in different conditions. We also extend our algorithm to the automated parallel parking and three-dimensional path planning.
Absorbed dose perturbation caused by diodes for small field photon dosimetry (1994)

Uncertainties in dose measurements which may be considered acceptable for standard radiotherapy techniques may not be acceptable for radiosurgery or other precision radiotherapy techniques. One example of this type of uncertainty are the small perturbations to measured dose distributions which are caused by the use of diode detectors. In this article the effect of using diodes to measure small field penumbra is assessed and comments are made about diode orientation and diode construction.
The Semantic Web: ESWC 2018 Satellite Events (2018)

The ESWC 2018 Satellite Events book is dealing with all areas of semantic web research. It includes the accepted contributions from the Poster and Demo session; the PhD symposium, and several workshops which were held around the main Extended Semantic Web conference.
Changes of haptoglobin and free hemoglobin due to blood transfusion. (1995)

Serum total haptoglobin and free hemoglobin levels during blood transfusion were investigated in 17 elective surgeries. Total haptoglobin and free hemoglobin levels in 73 stored whole blood were also investigated for different storage periods. Free hemoglobin was detected in serum when total haptoglobin level became 130 mg/dl or less and a mean storage period of transfused bloods were 11 days or longer. Total haptoglobin level became 130 mg/dl or less at a transfusion volume of 600 ml or more. No constant relationship was recognized between transfusion speed and total haptoglobin or free hemoglobin levels. In the stored whole blood, free hemoglobin level increased in accordance with an increase of storage period and it reached significant increase on 7-9 storage period against 1-3 storage period. The detection rate of free hemoglobin increased significantly when it was stored for 7 days or longer. It was concluded that 7 days or more stored whole bloods had free hemoglobin, but serum free hemoglobin was detected when 600ml or more of 11 days or longer whole bloods were transfused.
Polysiloxane-based photorefractive polymers for digital holographic data storage (1996)

A photorefractive polymer system based on a substituted polysiloxane backbone is described. In addition to high holographic diffraction efficiency and reasonable writing speed, the material reported exhibits excellent optical clarity and low optical scattering characteristics. These latter optical properties are necessary in high density holographic digital data storage applications. The utility of the polysiloxane based photorefractive polymers for storage applications is demonstrated by recording digital data at a density of 0.52 Mbit/cm2 and reading it back without error.
Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency (2005)

We have created a mouse model with an isolated cytochrome c oxidase (COX) deficiency by disrupting the COX10 gene in skeletal muscle. Missense mutations in COX10 have been previously associated with mitochondrial disorders. Cox10p is a protoheme:heme-O-farnesyl transferase required for the synthesis of heme a, the prosthetic group of the catalytic center of COX. COX10 conditional knockout mice were generated by crossing a LoxP-tagged COX10 mouse with a transgenic mouse expressing cre recombinase under the myosin light chain 1f promoter. The COX10 knockout mice were healthy until approximately 3 months of age when they started developing a slowly progressive myopathy. Surprisingly, even though COX activity in COX10 KO muscles was <5% of control muscle at 2.5 months, these muscles were still able to contract at 80-100% of control maximal forces and showed only a 10% increase in fatigability, and no signs of oxidative damage or apoptosis were detected. However, the myopathy worsened with time, particularly in female animals. This COX10 KO mouse allowed us to correlate the muscle function with residual COX activity, an estimate that can help predict the progression pattern of human mitochondrial myopathies.
<i>Comamonas testosteroni</i> meningitis in a patient with recurrent cholesteatoma (2003)

Comamonas testosteroni, a lesser-known member of the genus, has shown little apparent capacity for causing infections in humans. We here present a case of purulent meningitis due to C. testosteroni, which occurred in a patient who had recurrent cholesteatoma. Ceftriaxone treatment was not effective in this patient even though in vitro the bacteria were susceptible to the drug. The patient responded well to meropenem therapy.
LELISP, a portable and efficient LISP system (1984)

This paper describes the LELISP system, developed at the VLSI project at INRIA, which has been designed for efficiency, easy transport and large systems construction. It also presents the programming environment (including an object oriented extension, a meta pretty printer, a parser generator, a universal editor) and some current applications.
Control of photoluminescence from porous silicon (1992)

A description of ion-irradiation-induced reduction in the photoluminescence (PL) signal from porous silicon is given and a simple model which is consistent with a nanocrystalline Si structure is presented. Ion irradiation with 250 keV Ne is used to controllably reduce the integrated PL signal by 20% after a fluence of 4*1012 Ne cm-2 and completely eliminate the PL signal after a fluence of 4*1013 Ne cm-2. The use of vacuum and air annealing to recover ion-induced damage is also described, but the high temperatures for annealing cause elimination of the PL signal.
Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain (2004)

Abstract Monocarboxylate transporters (MCTs) are involved in the uptake and release of lactate, pyruvate, and ketone bodies. Studies of their distribution at both the mRNA and protein levels have highlighted the specific expression of MCT1, MCT2, and more recently MCT4 in the central nervous system. MCT1 was found strongly expressed by cortical astrocytes both in vitro and in vivo. It was also found at high levels on blood vessels, ependymocytes, and glia limitans. A subset of neurons in vitro exhibited a weak but significant MCT1 expression. In contrast, it was determined that MCT2 represents the predominant neuronal MCT on cultured neurons as well as on neurons throughout the brain parenchyma. At the subcellular level, part of MCT2 is located in postsynaptic densities. Specific populations of astrocytes in the white matter also exhibited MCT2 expression in the rat, but not in the mouse brain. MCT4 was found exclusively in astrocytes in several areas including the cortex, the hippocampus, and the cerebellum. MCT2 expression increased in cultured neurons with days in vitro commensurate with increased synapse formation. Moreover, a significant increase in MCT2 expression was observed in cultured neurons exposed to noradrenaline, an effect involving a regulation at the translational level. The description of MCTs on different cell types in the central nervous system together with clear evidence for regulation of their expression further emphasize the important role that monocarboxylates, and particularly lactate, might play in brain energy metabolism not only during development but also in the adult. © 2004 Wiley‐Liss, Inc.
A passive surveillance scheme for passive branched optical networks (2002)

In summary, we have proposed and experimentally demonstrated a practical fibre link in-service surveillance scheme using fibre Bragg gratings (FBGs) for fault identification in branched optically amplified networks without requiring any extra light source.
Aspects of optical frequency-domain reflectometry (1981)

Optical time-domain reflectometry (OTDR) has proved to be a useful tool for fiber and fault diagnostics1 in the laboratory and in operating systems. This work is a preliminary analytical and experimental investigation of optical frequency-domain reflectometry (OFDR), applying swept frequency rather than pulse techniques.
Islanding detection with Phasor Measurement Units (2014)

This paper briefly discusses the challenges related to the Islanding operation in power systems and presents different methods to detect the islanding condition with an example of photovoltaic applications. Furthermore, it proposes a secure method of islanding detection using synchrophasors. The proposed algorithm has been verified with Real Time Digital Simulator (RTDS) tests, as well as in laboratory environment with an inverter connected to grid. With the help of extensive testing, it is demonstrated that the proposed method successfully performs automatic and manual decisions to assure the correct and secure operation of the distribution grid.
Engineering the Electric and Magnetic Response of All-Dielectric Metasurfaces through Core-Shell Mie Resonators (2020)

In this contribution, we discuss two different strategies aimed at tailoring the electric and magnetic response of an all-dielectric metasurface. Specifically, we investigate the possibilities enabled by two different families of core-shell meta-atoms: concentric all-dielectric spheres and homogenous spheres covered by a reactive layer. The analysis of the scattering properties of these two classes of particles reveals intriguing effects that can be used for the design of innovative metasurfaces exploiting the entire multipolar response of their meta-atoms. Several examples are considered and investigated both analytically and numerically.
Viscoelastic properties of alginate aqueous solutions in the presence of salts (1990)

Abstract The influence of added salts on the dynamic viscoelastic properties are investigated for aqueous solutions of alginates that have various molecular weights and mannuronate/guluronate (M/G) ratios. The dynamic moduli of the systems increase with increasing concentration of the added salt in the low‐frequency region. The effect is notable in the order of KCl < NaCl < MgCl 2 ≪ CaCl 2 . The values of the dynamic moduli in the rubbery plateau are independent of the addition of the salts, irrespective of the M/G ratio of the alginate. These facts strongly suggest that the structure that is formed by the interaction between the alginates and the metal ions does not work as cross‐linking points but as heterogeneous relaxation units having a relatively long relaxation time from a rheological viewpoint.
A mobile biosensor to detect cardiorespiratory activity for stress tracking (2013)

Stress is an increasingly recognized phenomenon that has negative effects on growing numbers of people. Stress assessment is a complex issue, but different studies have shown that monitoring user psychophysiological parameter during daily life can be greatly helpful in stress evaluation. In this stu
Design and construction of the fibre system for FMOS (2008)

A consortium of Japanese, Australian and UK groups has developed a fibre-fed near IR (J & H band) multi-object spectrographic facility (FMOS) for the Subaru telescope. In this second-generation instrument, a novel prime focus 400-fibre multi-object positioning system, ECHIDNA, is optically linked via twin cables to dual IR spectrographs. The spectrographs are located some distance away, on a dedicated platform two levels above Nasmyth. The Centre for Advanced Instrumentation at Durham University oversaw the design and construction of the optical fibre system linking ECHIDNA to the spectrographs. A modularised connector within the cable scheme and an integral back illumination unit additionally featured as part of the Durham work-package. At the time of writing (mid 2008) FMOS, including the fibre system, is installed and functional on-telescope, with commissioning currently underway. This paper provides an overview of the design and construction of the optical fibre system.
Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation (2006)

These results suggest that Akt phosphorylation without ligand stimulation may play a key signaling role in gefitinib sensitivity, especially intermediate-sensitivity. In addition, expression analyses of the EGFR family, EGFR gene mutation, and FISH (fluorescence in situ hybridization) analyses showed that the phosphorylated state of EGFR and Akt might be a useful clinical marker of Akt activation without ligand stimulation, in addition to EGFR gene mutation and amplification, particularly in adenocarcinomas.
Personal ontologies (1999)

Corporations can suffer from too much information, and it is often inaccessible, inconsistent, and incomprehensible. The corporate solution entails knowledge management techniques and data warehouses. The paper discusses the use of the personal ontology. The promising approach is an organization scheme based on a model of an office and its information, an ontology, coupled with the proper tools for using it.
Studies of cervical ripening in pregnant rats: effects of various treatments (2000)

The exact mechanisms that regulate cervical softening or ripening during pregnancy are not completely understood. The aim of this study was to estimate the effects of various agents on cervical softening during pregnancy in rats. Cervical resistance was examined after treatment with nitric oxide (NO) donors and inhibitors and different hormonal agents. Cervical resistance was significantly reduced (P< 0.05) in rats treated with the NO donors: sodium nitroprusside, molsidomine and prostaglandin E(2). However, treatments with the NO synthase (NOS) inhibitors N(omega)-nitro-L-arginine methyl ester (L-NAME) and L-N(6)-1-iminoethyl-lysine (L-NIL), or the prostaglandin synthesis inhibitor, indomethacin, significantly increased resistance (P<0.05). The antiprogesterone, onapristone, reduced cervical resistance and its effects were only partially blocked by the progesterone agonist, promegestone. Relaxin reduced cervical resistance and NOS inhibitors partially blocked the effect of relaxin. These studies demonstrate that NO regulates cervical ripening. Relaxin also softens the cervix and may act by stimulating NO synthesis. Progesterone seems important in the control of cervical ripening, but its role appears complex. NO and prostaglandin pathways may independently control ripening by acting in parallel or synergistically.
A Simulation Tool for Space-Time Adaptive Processing in GPS (2006)

With the wide use of GPS, it becomes more and more important to improve the positioning accuracy. The GPS signal is very weak, and can be easily interfered. Space-time adaptive processing(STAP) can suppress the jamming not only in the temporal domain, but also in the spatial domain. STAP has now become a good candidates for jamming mitigation in GPS. In order to evaluate the performance of various kinds of STAP algorithms, and to develop the novel STAP algorithms. we need to simulate space-time array GPS data with high fidelity and the software GPS receiver. This paper mainly presents a simulation method for space-time GPS data, as well as the simulation of some typical kinds of jammers. The simulation method for software GPS receiver is also introduced. The data that after the process of STAP is computed by the simulated GPS receiver. The simulation results show that the simulation tool is a good platform for the development of STAP algorithms.
Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFκB, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line (2002)

Approximately 10% of the U.S. population ingests <50% of the current recommended daily allowance for zinc. We investigate the effect of zinc deficiency on DNA damage, expression of DNA-repair enzymes, and downstream signaling events in a cell-culture model. Low zinc inhibited cell growth of rat glioma C6 cells and increased oxidative stress. Low intracellular zinc increased DNA single-strand breaks (comet assay). Zinc-deficient C6 cells also exhibited an increase in the expression of the zinc-containing DNA-repair proteins p53 and apurinic endonuclease (APE). Repletion with zinc restored cell growth and reversed DNA damage. APE is a multifunctional protein that not only repairs DNA but also controls DNA-binding activity of many transcription factors that may be involved in cancer progression. The ability of the transcription factors p53, nuclear factor kappaB, and activator protein 1 (AP1) to bind to consensus DNA sequences was decreased markedly with zinc deficiency, as assayed by electrophoretic mobility-shift assays. Thus, low intracellular zinc status causes oxidative DNA damage and induces DNA-repair protein expression, but binding of p53 and important downstream signals leading to proper DNA repair are lost without zinc.
Tangible user interaction using augmented reality (2002)

This paper describes a novel use of augmented reality for the visualisation of virtual objects as part of the move towards pervasive computing. It uses fiducial markers as switches to toggle the displayed properties of the virtual objects. Using collision detection, fiducial markers are also used to track and select nodes within virtual objects. This research uses the ARToolkit Version 2.33 and acts as a component within the DSTO's InVision framework.
Treatment Options and Considerations for Intestinal Helminthic Infections (2014)

<b>Objective:</b> To review the literature regarding the epidemiology and treatment of intestinal helminthic infections. <b>Data Sources:</b> A literature search of MEDLINE (1946-January 2014), EMBASE (1980-January 2014), International Pharmaceutical Abstracts (1970-January 2014), and the Cochrane Library (1996-January 2014) was performed using the following terms: intestinal, helminthic, humans, United States, and individual drug names (albendazole, ivermectin, mebendazole, nitazoxanide, praziquantel, pyrantel pamoate). Secondary and tertiary references were obtained by reviewing related articles. <b>Study Selection and Data Extraction:</b> All English-language articles identified from the data sources and clinical studies using anthelmintic agents were included. <b>Data Synthesis:</b> The 2011 removal and continued absence of mebendazole from the market has left limited options for helminth infections. For hookworm, albendazole has a 72% cure rate compared to 32% for pyrantel pamoate. Albendazole, ivermectin, and nitazoxanide appear to be effective for <i>Ascaris</i> with cure rates of 88%, 100%, and 91%, respectively. Both albendazole and pyrantel pamoate have been evaluated for pinworm with cure rates of 94.1% and 96.3%, respectively. Combination therapy with ivermectin and albendazole produces cure rates of 38% to 80% for whipworm. For <i>Strongyloides stercoralis</i>, ivermectin cure rates are 93.1% to 96.8% compared with 63.3% for albendazole. Praziquantel is effective for intestinal trematode infections with cure rates of 97% to 100% while its efficacy against tapeworm ranges from 75% to 85%. <b>Conclusions:</b> Albendazole is the drug of choice for hookworm, <i>Ascaris lumbricoides</i>, and pinworm. In combination with ivermectin, it is the first-line agent for whipworm. Ivermectin is preferred for <i>Strongyloides</i> stercoralis, and praziquantel is effective against most nematodes and trematodes.
The "Lungworm", Filaroides Milksi, in Iowa Dog (1960)

The purpose of this report is to describe for the first time the lungworm Filaroides milksi in a dog in Iowa.
Bicyclic Homologs of Piperazine. II. Synthesis of 3,8-Diazabicyclo[3.2.1]octane. New Synthesis of 8-Methyl-3,8-diazabicyclo[3.2.1]octane (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBicyclic Homologs of Piperazine. II. Synthesis of 3,8-Diazabicyclo[3.2.1]octane. New Synthesis of 8-Methyl-3,8-diazabicyclo[3.2.1]octaneGIORGIO CIGNARELLA, GIANGIACOMO NATHANSOHN, and EMILIO OCCELLICite this: J. Org. Chem. 1961, 26, 8, 2747–2750Publication Date (Print):August 1, 1961Publication History Published online1 May 2002Published inissue 1 August 1961https://pubs.acs.org/doi/10.1021/jo01066a031https://doi.org/10.1021/jo01066a031research-articleACS PublicationsRequest reuse permissionsArticle Views444Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts