gebhart/patrepeval huggingface dataset:
Limitation of the deterioration of lipid parameters by a standardized garlic-ginkgo combination product. A multicenter placebo-controlled double-blind study. (1993)

The efficacy of a garlic-ginkgo combination product (Allium plus) was analyzed in a randomized placebo-controlled double-blind study under extreme dietary conditions. The Christmas/New Year's season was chosen for this 2 months lasting investigation analyzing whether the known cholesterol lowering effect of garlic was even effective during the period of the year with the most cholesterol-rich meals. 43 patients with elevated total cholesterol levels ranging between 230-390 mg/dl completed the study. There were no significant changes of the total cholesterol values in both treatment groups. Nevertheless the analysis of improvement or deterioration of total cholesterol values revealed a clear difference between verum and placebo. 20% of the patients in the placebo group showed an improvement of their total cholesterol level, while there was a significant greater improvement rate of 35% in the verum group (p < 0.05). The responders of the verum group showed a reduction in the total cholesterol values from 298.5 +/- 53.8 to 293.0 +/- 56.4 mg/dl after 1 month and a total reduction of 10.4% after 2 months to 267.6 +/- 44.4 mg/dl. The difference after 2 months of treatment was significantly different from the starting value (p < 0.05). After the 2 months treatment phase there was a 2 weeks wash-out period. During this period the total cholesterol value returned to 293.5 +/- 90.1 mg/dl showing the effectiveness of garlic treatment, but indicating the need for a continuous long-term therapy.
Influence of forming conditions on the titanium model in rapid prototyping with the selective laser melting process (2003)

In order to evaluate the titanium model to be used for medical purposes in rapid prototyping with the selective laser melting process, the influence of forming conditions on the mechanical properties is investigated. The density and mechanical properties such as tensile and fatigue strengths of the model are measured. In the selective laser melting process, a pulsed yttrium aluminium garnet (YAG) laser with average power of 50 W and maximum peak power of 3 kW is used. The specimens for measuring density and mechanical properties are made from commercial pure titanium powders (grade 1) in a controlled atmosphere with argon gas. It is found that the relative density of the model is higher than 92 per cent and some powder particles remain within the solidified model. The scan speed affects the tensile strength strongly and the tensile strength is around 120 per cent of the standard value of the solid pure titanium when the scan speed is appropriate. However, the fatigue strength is low, about 10 per cent of the solid one, which is still to be improved by post-processing.
Comparison between the LCx Probe System and the COBAS AMPLICOR System for Detection of <i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> Infections in Patients Attending a Clinic for Treatment of Sexually Transmitted Diseases in Amsterdam, The Netherlands (2001)

Two assays for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae were compared: the LCx Probe system (the LCx system; Abbott Diagnostic Laboratories, North Chicago, Ill.) and the COBAS AMPLICOR C. trachomatis/N. gonorrhoeae system (the COBAS AMPLICOR system; Roche Diagnostic Systems, Branchburg, N.J.). Endocervical swab specimens, male urethral swab specimens, and female and male urine specimens were collected from 503 female and 498 male visitors attending a sexually transmitted diseases clinic in Amsterdam, The Netherlands. Prevalences for C. trachomatis were 12.5% (63 of 503) and 10.0% (50 of 498) in females and males, respectively. The prevalences for N. gonorrhoeae were 1.2% (6 of 503) and 4.2% (21 of 498) in females and males, respectively. Both assays showed high values for sensitivity and specificity with regard to the detection of C. trachomatis in endocervical swab specimens, male urethral swab specimens, and female and male urine specimens. The sensitivities for the LCx system were 92.1, 90.0, 88.9, and 94.0% for each type of specimen, respectively; and the sensitivies for the COBAS AMPLICOR system were 96.8, 98.0, 82.5, and 92.0% for each type of specimen, respectively. Specificities ranged between 98.4 and 100%. The sensitivity of the LCx system for the detection of N. gonorrhoeae was 100% for female cervical swab and urine specimens and male urethral swab specimens, while for male urine specimens the sensitivity was 95.2%; the specificity was 100% for all types of specimens. For the detection of N. gonorrhoeae by the COBAS AMPLICOR assay, the sensitivity for female cervical swab and male urethral swab specimens was 100%, that for female urine specimens was 66.7%, and that for male urine specimens was 95.2%. However, the predictive values of a positive test for female cervical swab specimens and urine specimens were 31.6 and 36.4%, respectively. Sequence analysis of the amplimers obtained by an in-house 16S rRNA PCR of the solely COBAS AMPLICOR system-positive swab specimens revealed neither N. gonorrhoeae nor other Neisseria spp. The COBAS AMPLICOR assay was considered not suitable for screening for infections with N. gonorrhoeae. If this assay is used for detection of N. gonorrhoeae, confirmation of positive results by a reliable test is mandatory.
The performance of HIPERLAN/2 systems with multiple antennas (2002)

This paper investigates the performance of the ETSI HIPERLAN/2 standard with dual antenna diversity utilized at mobile terminals. Software-simulated physical layer packet error rate (PER) results are presented tor both transmit (up-link) and receive (down-link) diversity configurations. The impact of the improved physical layer performance that results from the use of multiple antennas is discussed in terms of increased throughput on the down-link and reduced transmit power on the uplink.
HECT E3s and human disease (2007)

In a simplified view, members of the HECT E3 family have a modular structure consisting of the C-terminal HECT domain, which is catalytically involved in the attachment of ubiquitin to substrate proteins, and N-terminal extensions of variable length and sequence that mediate the substrate specificity of the respective HECT E3. Although the physiologically relevant substrates of most HECT E3s have remained elusive, it is becoming increasingly clear that HECT E3s play an important role in sporadic and hereditary human diseases including cancer, cardiovascular (Liddle's syndrome) and neurological (Angelman syndrome) disorders, and/or in disease-relevant processes including bone homeostasis, immune response and retroviral budding. Thus, molecular approaches to target the activity of distinct HECT E3s, regulators thereof, and/or of HECT E3 substrates could prove valuable in the treatment of the respective diseases. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
Regulation of antigen presentation by acidic pH. (1990)

The effect of pH on functional association of peptide antigens with APC membranes was investigated by using aldehyde-fixed B cells and class II-restricted T cell hybridomas to assess antigen/MHC complex formation. The results indicated that the rate and extent of functional peptide binding was markedly increased at pH 5.0 as compared with pH 7.3. The pH dependence of binding was preserved after pretreatment of fixed APC with pH 5.0 buffer, suggesting that pH had a direct effect on the interaction of peptide with the APC membrane. Similar results were obtained by using several peptides and I-Ad- and I-Ed-restricted T cells, indicating that pH may be of general importance in regulating the formation of functional antigen/class II MHC complexes.
Superfield Equations (1975)

Abstract Covariant free field equations are systematically derived for irreducible and bilinear superfields from representation theory of the Wess‐Zumino algebra. Interactions are introduced by covariance arguments alone or by the principle of local gauge invariance. Finally we construct propagators for massive superfields.
In vitro Studies on the Integrated Control of Rapeseed White Stem Rot Disease through the Application of Herbicides and Trichoderma Species (2006)

Five herbicides commonly used in rapeseed crop, canola (Brassica napus var Olifera) fields in Iran were studied with an eye to their antifungal activities against six isolates of Trichoderma species and also the phytopathogenic fungus Sclerotinia sclerotiorum. The doses tested were the same as are recommended for applications in canola crops. The results showed that the dinitro aniline herbicides (trifluralin and ethalfluralin) had the highest antifungal activities in vitro on the toxified CDA media; also three other herbicides behaved differently in relation to the fungi investigated. Cycloxydim had the most toxicity against Trichoderma sp. and sethoxydim had the least deleterious effects. But, with, Sclerotinia sclerotiorum, sethoxydim had the most toxicity together with cycloxydim with an intermediate level of anti-fungal activity between sethoxydim and haloxy fop ethoxy ethyl. This may be the first global report of the antifungal activities of the haloxy fop ethoxy ethyl, ethanol fluralin and cycloxydim.
Forming of Electron Beams from A Betatron by Foil Scatterers (1976)

The technique of forming electron beams by one scattering foil and one compensating foil is discussed. This method provides a means for producing large-size uniform dose distributions with much smaller losses in dose rate as compared with conventional beam forming by one foil. Moreover, the energy losses involved in this process and the background [corrected] of concomitant bremsstrahlung are much less. A technique of calculation to determine approximate parameters of the compensating foils is described.
Calcification and endothelialization of thrombi in acute stroke (2008)

We report chronic histopathological features in thrombi mechanically retrieved from five acute ischemic stroke patients with a median age of 68 years and a median pretreatment National Institutes of Health Stroke Scale score of 13. Early endothelialization occurred over and within the thrombus, and calcifications were seen, in addition to the usual acute laminar fibrin, intervening red blood cells, and neutrophils. The effectiveness of tissue plasminogen activator in clot dissolution might be affected by these features, if extensive. Thrombus composition could critically determine the success of chemical thrombolysis. Our results should stimulate the development of imaging modalities to determine thrombus composition.
Growth arrest-specific protein 6 (GAS6) and the protein C pathway (2007)

This topic letter concenrns two recent studies reporting that the level of plasma GAS6 was elevated and correlated with disease severity in patients with severe sepsis and septic shock and fruther discusses a possible link between GAS6 and the protein C pathway.
Total serum protein <b><i>N</i></b>‐glycome profiling on a capillary electrophoresis‐microfluidics platform (2004)

We implemented 8-aminopyrene-1,3,6-trisulfonic acid (APTS)-labeled asparagine-linked glycan (N-glycan) profiling on a microfluidic electrophoresis platform. Using 11.5 cm effective length etched channels and 4% linear polyacrylamide as the separation matrix, the major N-glycans in human serum were profiled in 12 min with a resolution comparable to what is achieved for these analytes on gel-based DNA sequencers. This demonstration suggests a practical clinical application for high-speed compact analyzers which might be uniquely based on microfluidic devices.
The role of oxytocin antagonists in repeated implantation -failure. (2012)

A prospective cohort study has been performed to find out if the administration of an oxytocin antagonist (Atosiban) at the occasion of embryo transfer has an effect on the pregnancy rate in patients with repeated failure of implantation. A total of 52 women with repeated failure of implantation after IVF/ICSI were included in this study. The ongoing pregnancy rate (OPR) in the total group of patients was 12 out of 52 (23.1%). Based on embryo quality all cases were categorized in two groups. One with good embryo quality (Group A) and one with poor quality embryos (Group B). Of all patients who became pregnant, 11 belonged to the group of 26 patients with good quality embryos (OPR 42.3 %) and only one to the group of 26 patients with poor quality embryos (OPR 3.8 %). Our results indicate that when good quality embryos can be obtained, the use of Atosiban at the occasion of embryo transfer might offer a significant better implantation rate in women with repeated implantation failure after IVF/ICSI.
A stereoselective total synthesis of estrone by an intramolecular cycloaddition reaction of olefinic o-quinodimethane (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA stereoselective total synthesis of estrone by an intramolecular cycloaddition reaction of olefinic o-quinodimethaneTetsuji Kametani, Hideo Nemoto, Hisako Ishikawa, Keiko Shiroyama, Hiroo Matsumoto, and Keiichiro FukumotoCite this: J. Am. Chem. Soc. 1977, 99, 10, 3461–3466Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://pubs.acs.org/doi/10.1021/ja00452a045https://doi.org/10.1021/ja00452a045research-articleACS PublicationsRequest reuse permissionsArticle Views525Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Sample Handling and Analysis of Pesticides and Their Transformation Products in Water Matrices by Liquid Chromatographic Techniques (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electroluminescent Display Technology (1980)

DisplaysThin-film Flat Panel High Contrast Electroluminescense [0? ABSTRACT (C-.n1.nu •e ,r ,.ee elde I* neceeearv a" Identliy by block em.Mb)-The development of the current high contrast, sunlight lecible, thin-film electroluminescent display technology will be reviewed ant device structures and operating characteristics will be described.Drive ard addressing considerations will be presented in relation to device types power dissipation, multiplexing and viewability'.'An overview of the industr3 status will be qiven including device availability and problems remaining to bc solved.Applice-..tions uf the technology will be reviewed covering both user requirements ard DD ,JAN73
Revealing Packed Malware (2008)

To evade malicious content detection, malware authors use packers, binary tools that instigate code obfuscation. By using executable packers, modern malware can completely bypass personal firewalls and antivirus (AV) scanners.Reverse engineering (RE) has become an important approach to analyzing a program's logic flow and internal data structures, such as system call functions. Security researchers and AV products must be able to unpack and inspect the payloads hidden within the packed programs using RE tools.
Nanostructured origami (2004)

We present a method to manufacture three-dimensional (3D) nanostructures by folding 2D nanopatterned membranes. The manufacturing process consists of two steps. During the first step, 2D nanopatterning on the membrane takes place, including the definition of the folding apparatus, such as creases and actuators. Subsequently, a "folding sequence" is initiated, resulting in the nanostructures taking their desired configuration in 3D space in the final folded structure. We present in detail a simple case study, including the design, modeling, fabrication and testing of a single folding silicon segment with gold hinges. We have achieved folding rotation up to 180 degrees with /spl sim/20 msec actuation time and alignment better than 10 /spl mu/m.
Simplified intersubject averaging on the cortical surface using SUMA (2005)

Task and group comparisons in functional magnetic resonance imaging (fMRI) studies are often accomplished through the creation of intersubject average activation maps. Compared with traditional volume-based intersubject averages, averages made using computational models of the cortical surface have the potential to increase statistical power because they reduce intersubject variability in cortical folding patterns. We describe a two-step method for creating intersubject surface averages. In the first step cortical surface models are created for each subject and the locations of the anterior and posterior commissures (AC and PC) are aligned. In the second step each surface is standardized to contain the same number of nodes with identical indexing. An anatomical average from 28 subjects created using the AC-PC technique showed greater sulcal and gyral definition than the corresponding volume-based average. When applied to an fMRI dataset, the AC-PC method produced greater maximum, median, and mean t-statistics in the average activation map than did the volume average and gave a better approximation to the theoretical-ideal average calculated from individual subjects. The AC-PC method produced average activation maps equivalent to those produced with surface-averaging methods that use high-dimensional morphing. In comparison with morphing methods, the AC-PC technique does not require selection of a template brain and does not introduce deformations of sulcal and gyral patterns, allowing for group analysis within the original folded topology of each individual subject. The tools for performing AC-PC surface averaging are implemented and freely available in the SUMA software package.
Repression of Platelet-Derived Growth Factor β-Receptor Expression by Mitogenic Growth Factors and Transforming Oncogenes in Murine 3T3 Fibroblasts (1995)

Platelet-derived growth factor BB (PDGF-BB) is an important extracellular factor for regulating the G0-S phase transition of murine BALB/c-3T3 fibroblasts. We have investigated the expression of the PDGF beta receptor (PDGF beta R) in these cells. We show that the state of growth arrest in G0, resulting from serum deprivation, is associated with increased expression of the PDGF beta R. When the growth-arrested fibroblasts are stimulated to reenter the cell cycle by the mitogenic action of serum or certain specific combinations of growth factors, PDGF beta R mRNA levels and cell surface PDGF-BB-binding sites are markedly downregualted. Oncogene-transformed 3T3 cell lines, which fail to undergo growth arrest following prolonged serum deprivation, express constitutively low levels of the PDGF beta R mRNA and possess greatly reduced numbers of cell surface PDGF receptors, as determined by PDGF-BB binding and Western blotting (immunoblotting). Nuclear runoff assays indicate the mechanism of repression of PDGF beta R expression to be, at least in large part, transcriptional. These data indicate that expression of the PDGF beta R is regulated in a growth state-dependent manner in fibroblasts and suggest that this may provide a means by which cells can modulate their responsiveness to the actions of PDGF.
Activation of Host Cell Phosphatidylinositol 3-Kinases byTrypanosoma cruzi Infection (2000)

Trypanosoma cruzi, the causative agent of Chagas' disease in humans, is an intracellular protozoan parasite with the ability to invade a wide variety of mammalian cells by a unique and remarkable process in cell biology that is poorly understood. Here we present evidence suggesting a role for the host phosphatidylinositol (PI) 3-kinases during T. cruzi invasion. The PI 3-kinase inhibitor wortmannin marked inhibited T. cruzi infection when macrophages were pretreated for 20 min at 37 degrees C before inoculation. Infection of macrophages with T. cruzi markedly stimulated the formation of the lipid products of the phosphatidylinositol (PI) 3-kinases, PI 3-phospate, PI 3,4-biphosphate, and PI 3,4,5-triphosphate, but not PI 4-phosphate or PI 4,5-biphosphate. This activation was inhibited by wortmannin. Infection with T. cruzi also stimulated a marked increase in the in vitro lipid kinase activities that are present in the immunoprecipitates of anti-p85 subunit of class I PI 3-kinase and anti-phosphotyrosine. In addition, T. cruzi invasion also activated lipid kinase activity found in immunoprecipitates of class II and class III PI 3-kinases. These data demonstrate that T. cruzi invasion into macrophages strongly activates separated PI 3-kinase isoforms. Furthermore, the inhibition of the class I and class III PI 3-kinase activities abolishes the parasite entry into macrophages. These findings suggest a prominent role for the host PI 3-kinase activities during the T. cruzi infection process.
VLSI design of dynamically reconfigurable array processor-DRAP (2003)

A novel 2-D bidirectional, reconfigurable systolic array is presented. The system can be easily reconfigured and applied in many DSP and matrix processing applications. The different interconnection schemes are achieved by a set of simple local switches that contributes only a 15% increase in the chip area. The processor was implemented in 2- mu m CMOS technology and was tested for 1-D linear, 2-D square-mesh, and 2-D hexagonal structures. Another feature of this system is that its configuration patterns can be expanded to support additional algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
MET as Program Resources for College English Teaching and Learning: Application and Implications (2006)

This paper investigates the current situation of Modern Educational Technology (MET) as program resources for college English teaching, exploring the effectiveness of the integration of MET and language teaching and learning. The case study in this paper illustrates that MET does benefit college English teaching but there are many problems of its application. Pedagogical implications are then provided to enhance the effective integration of MET and language teaching and learning: (1) it is wise for the teachers and learners to reconcile what is desirable with what is acceptable and possible in MET application; (2) teachers should optimize other existing resources to solve the problems caused by inequality and unavailability of MET; (3) teachers should have a clear conception of the relationship of MET and pedagogy to design and apply courseware appropriately; (4) students have beliefs in the benefits of MET, resulting in enhancing their individual language learning and efficiency.