gebhart/patrepeval huggingface dataset:
Efficient Parallel Carrier Recovery for Ultrahigh Speed Coherent QAM Receivers with Application to Optical Channels (2013)

This work presents a new efficient parallel carrier recovery architecture suitable for ultrahigh speed intradyne coherent optical receivers (e.g., ≥100 Gb/s) with quadrature amplitude modulation (QAM). The proposed scheme combines a novel low-latency parallel digital phase locked loop (DPLL) with a feedforward carrier phase recovery (CPR) algorithm. The new low-latency parallel DPLL is designed to compensate not only carrier frequency offset but also frequency fluctuations such as those induced by mechanical vibrations or power supply noise. Such carrier frequency fluctuations must be compensated since they lead to higher phase error variance in traditional feedforward CPR techniques, significantly degrading the receiver performance. In order to enable a parallel-processing implementation in multigigabit per second receivers, a new approximation to the DPLL computation is introduced. The proposed technique reduces the latency within the feedback loop of the DPLL introduced by parallel processing, while at the same time it provides a bandwidth and capture range close to those achieved by a serial DPLL. Simulation results demonstrate that the effects caused by frequency deviations can be eliminated with the proposed low latency parallel carrier recovery architecture.
Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism (2005)

Mutations of the GnRHR and of the GPR54 gene are rare in IHH and should be investigated especially in cases with autosomal recessive transmission. Common SNPs of the GnRHR and GPR54 genes do not play any role in IHH.
Impact of dopamine transporter SPECT using <sup>123</sup>I‐Ioflupane on diagnosis and management of patients with clinically uncertain parkinsonian syndromes (2004)

Imaging with (123)I-Ioflupane single-photon emission computed tomography (SPECT) is a marker of nigrostriatal neuronal integrity, allowing differentiation of parkinsonism with loss of dopaminergic terminals (presynaptic Parkinson syndrome [PS]) from parkinsonism without nigrostriatal degeneration. This study assessed SPECT imaging in 118 patients with clinically uncertain parkinsonian syndromes (CUPS). In 36% of patients with presynaptic PS and 54% with nonpresynaptic PS, imaging results were not consistent with the initial diagnosis. After imaging, diagnosis was changed in 52% of patients. All patients with a final diagnosis of presynaptic PS had an abnormal image, whereas 94% of patients with nonpresynaptic PS had a normal scan. Imaging increased confidence in diagnosis, leading to changes in clinical management in 72% of patients. Consequently, visual assessment of (123)I-Ioflupane SPECT may have a significant impact on the clinical management of CUPS patients.
The maximum dielectric strength of thin silicon oxide films (1966)

Thin film silicon oxide capacitors with nonshorting breakdowns were investigated. Breakdowns appear in three forms: single hole, self-propagating, and maximum voltage breakdowns. Single hole and self-propagating breakdowns occur at flaws, and self-propagating breakdowns develop only when the resistor to the source is relatively small, less than 10 kΩ in these experiments. After flaws are burned out by single hole breakdowns, with larger source resistors the maximum voltage breakdown can be observed, destroying the whole capacitor simultaneously. Plotting current against voltage, the current increase is quasi-exponential, but prior to maximum voltage breakdown, the current continues to increase while the voltage decreases slightly below a maximum value V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</inf> . Assuming thermal instability as the cause for this change in the I-V relationship, we have derived an expression for the maximum voltage V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</inf> . Calculated results for fields up to 9.5 MV/cm were found to agree well with measurements for temperatures from -145°C to 65°C and for thicknesses from 3000 Å to 50 000 Å. F <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</inf> decreases with increasing temperature and thickness of insulation, and is higher for silicon dioxide than for silicon monoxide films. Maximum voltage breakdown occurs when the quasi-exponential increase of leakage current with field produces thermal instability over the whole capacitor area. The maximum dielectric strength is characteristic of the whole capacitor and is determined by its electrical and thermal conductance.
Self-excising integrative yeast plasmid vectors containing an intronated recombinase gene (2014)

Site-specific recombinases are widely used for selectable marker recycling in molecular-genetic manipulations with eukaryotic cells. This usually involves the use of two genetic constructs, one of which possesses a selectable marker flanked by the recombinase recognition sequences, while the other one bears the recombinase gene. Combining the recombinase gene with its recognition sequences in one plasmid is usually avoided, as it may lead to undesirable recombination due to promoter leakage, while the plasmid is maintained in Escherichia coli cells. Here, we describe yeast vectors possessing Cre recombinase genes under control of regulatable yeast promoters and loxP sequences for the in vivo vector backbone excision. The plasmid stability in E. coli is ensured by the presence of an intron in the recombinase gene. Applicability of these vectors was validated by disruptions of the Hansenula polymorpha PMC1 and Saccharomyces cerevisiae HSP104 and PRB1 genes.
A New Method for Detecting Bilateral Horner's Syndrome (1999)

Unilateral sympathetic deficits (i.e., miosis, ptosis, and redilatation lag) make unilateral Horner's syndrome recognizable, but bilateral Horner's
The role of autophagy in tumour development and cancer therapy (2009)

Autophagy is a catabolic membrane-trafficking process that leads to sequestration and degradation of intracellular material within lysosomes. It is executed at basal levels in every cell and promotes cellular homeostasis by regulating organelle and protein turnover. In response to various forms of cellular stress, however, the levels and cargoes of autophagy can be modulated. In nutrient-deprived states, for example, autophagy can be activated to degrade cargoes for cell-autonomous energy production to promote cell survival. In other contexts, in contrast, autophagy has been shown to contribute to cell death. Given these dual effects in regulating cell viability, it is no surprise that autophagy has implications in both the genesis and treatment of malignant disease. In this review, we provide a comprehensive appraisal of the way in which oncogenes and tumour suppressor genes regulate autophagy. In addition, we address the current evidence from human cancer and animal models that has aided our understanding of the role of autophagy in tumour progression. Finally, the potential for targeting autophagy therapeutically is discussed in light of the functions of autophagy at different stages of tumour progression and in normal tissues.
The Portable Inference Engine: Fitting significant expertise into small systems (1986)

The Portable Inference Engine (PIE) is the nucleus of an expert system that allows the segmentation of rules in order to utilize large knowledge bases in limited memory. If the expert-systems rules can be divided into segments of highly related rules with little interaction among those segments, such knowledge-base segments can then be paged in and out of memory on demand. PIE gathers information by querying the user and executing external procedures in order to conclude goals.
Multiple objective action selection in behavior-based control (1998)

. It is demonstrated that multiple objective decision theory provides a suitable formalism to encompass ideas from behavior-based system synthesis and control, where each behavior is cast as an objective function estimator. Action selection is comprised of generating and then selecting a set of satisficing solutions among a set of solutions that are Pareto-optimal. The basic ideas of the proposed methods are demonstrated through a set of simulated as well as real-world experiments. 1 Introduction In the behavior-based approach the control of a robot is shared between a set of purposive perception-action units, called behaviors. Based on selective sensory information, each behavior produces immediate reactions to control the robot with respect to a particular objective, i.e., a narrow aspect of the robot&apos;s overall task such as obstacle avoidance or wall following. Behaviors with different and possibly incommensurable objectives may produce conflicting actions that are seemingly irrecon...
Minireview: Therapeutic intervention in sepsis with antibody to endotoxin: is there a future? (1994)

Within the last 24 months a number of studies that tested the efficacy of immunologic reagents in the treatment of sepsis were concluded. Among these reports were 4 studies 1-4 completed on 2 anti-endotoxin monoclonal antibodies (MAb, HA-1A and E-5). These clinical trials did not generate data sufficient to support product licensure. Given the attention and expectations surrounding the anti-endotoxin MAbs, the disappointing results raised the question whether the use of anti-endotoxin antibodies in the treatment of sepsis was still a viable concept. 5 The question was rendered even more relevant given the decade-old controversy surrounding the efficacy of polyclonal antibodies to endotoxin, particularly antibody to the J5 (Rc chemotype) mutant of Escherichia coli 0111:B4, a conceptual progenitor of the HA-1A and E-5 MAbs. 6 In this review we shall examine whether anti-endotoxin antibodies may yet offer any therapeutic potential in the treatment of sepsis. It will be our contention that antibodies to core glycolipid will be useful adjuncts to therapy, particularly if used as part of combination immunotherapy.
High-Throughput Sequencing of Core STR Loci for Forensic Genetic Investigations using the Roche Genome Sequencer FLX Platform (2011)

The analysis and profiling of short tandem repeat (STR) loci is routinely used in forensic genetics. Current methods to investigate STR loci, including PCR-based standard fragment analyses and capillary electrophoresis, only provide amplicon lengths that are used to estimate the number of STR repeat units. These methods do not allow for the full resolution of STR base composition that sequencing approaches could provide. Here we present an STR profiling method based on the use of the Roche Genome Sequencer (GS) FLX to simultaneously sequence multiple core STR loci. Using this method in combination with a bioinformatic tool designed specifically to analyze sequence lengths and frequencies, we found that GS FLX STR sequence data are comparable to conventional capillary electrophoresis-based STR typing. Furthermore, we found DNA base substitutions and repeat sequence variations that would not have been identified using conventional STR typing.
rs5888 Variant of <em>SCARB1</em> Gene Is a Possible Susceptibility Factor for Age-Related Macular Degeneration (2015)

<div><p>Major genetic factors for age-related macular degeneration (AMD) have recently been identified as susceptibility risk factors, including variants in the <em>CFH</em> gene and the <em>ARMS2 LOC387715/HTRA1locus</em>. Our purpose was to perform a case-control study in two populations among individuals who did not carry risk variants for <em>CFHY402H</em> and <em>LOC387715 A69S (ARMS2)</em>, called “study” individuals, in order to identify new genetic risk factors. Based on a candidate gene approach, we analyzed SNP rs5888 of the <em>SCARB1</em> gene, coding for SRBI, which is involved in the lipid and lutein pathways. This study was conducted in a French series of 1241 AMD patients and 297 controls, and in a North American series of 1257 patients with advanced AMD and 1732 controls. Among these individuals, we identified 61 French patients, 77 French controls, 85 North American patients and 338 North American controls who did not carry the <em>CFH</em> nor <em>ARMS2</em> polymorphisms. An association between AMD and the <em>SCARB1</em> gene was seen among the study subjects. The genotypic distribution of the rs5888 polymorphism was significantly different between cases and controls in the French population (p<0.006). Heterozygosity at the rs5888 SNP increased risk of AMD compared to the CC genotypes in the French study population (odds ratio (OR) = 3.5, CI95%: 1.4–8.9, p<0.01) and after pooling the 2 populations (OR = 2.9, 95% CI: 1.6–5.3, p<0.002). Subgroup analysis in exudative forms of AMD revealed a pooled OR of 3.6 for individuals heterozygous for rs5888 (95% CI: 1.7–7.6, p<0.0015). These results suggest the possible contribution of <em>SCARB1</em>, <em>a</em> new genetic factor in AMD, and implicate a role for cholesterol and antioxidant micronutrient (lutein and vitamin E) metabolism in AMD.</p></div>
Protecting against vascular disease in brain (2011)

Endothelial cells exert an enormous influence on blood vessels throughout the circulation, but their impact is particularly pronounced in the brain. New concepts have emerged recently regarding the role of this cell type and mechanisms that contribute to endothelial dysfunction and vascular disease. Activation of the renin-angiotensin system plays a prominent role in producing these abnormalities. Both oxidative stress and local inflammation are key mechanisms that underlie vascular disease of diverse etiology. Endogenous mechanisms of vascular protection are also present, including antioxidants, anti-inflammatory molecules, and peroxisome proliferator-activated receptor-γ. Despite their clear importance, studies of mechanisms that underlie cerebrovascular disease continue to lag behind studies of vascular biology in general. Identification of endogenous molecules and pathways that protect the vasculature may result in targeted approaches to prevent or slow the progression of vascular disease that causes stroke and contributes to the vascular component of dementia and Alzheimer's disease.
THE CHRYSOTHAMNUS-ERICAMERIA CONNECTION (ASTERACEAE) (1995)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance (2006)

Oncogenic RAS expression occurs in up to 40% of multiple myeloma (MM) cases and correlates with aggressive disease. Since activated RAS induces cyclooxygenase-2 (cox-2) expression in other tumor models, we tested a role for cox-2 in mutant RAS-containing MM cells. We used the ANBL-6 isogenic MM cell lines in which the IL-6-dependent parental line becomes cytokine independent following transfection with mutated N-RAS or K-RAS. Both mutated N-RAS- and K-RAS-expressing ANBL-6 cells demonstrated a selective up-regulation of cox-2 expression and enhanced secretion of PGE2, a product of cox-2. Furthermore, in 3 primary marrow specimens, which contained MM cells expressing mutated RAS, 15% to 40% of tumor cells were positive for cox-2 expression by immunohistochemistry. We used cox-2 inhibitors, NS398 and celecoxib, and neutralizing anti-PGE2 antibody to test whether cox-2/PGE2 was involved in the aggressive phenotype of MM ANBL-6 cells containing mutated RAS. Although these interventions had no effect on IL-6-independent growth or adhesion to marrow stromal cells, they significantly inhibited the enhanced binding of mutant RAS-containing MM cells to fibronectin and the enhanced resistance to melphalan. These results indicate a selective induction of cox-2 in MM cells containing RAS mutations, which results in heightened binding to extracellular matrix protein and chemotherapeutic drug resistance.
A novel OFDM transmission scheme with length-adaptive Cyclic Prefix (2004)

Conventional OFDM transmission system uses a fixed-length Cyclic Prefix to counteract Inter-Symbol Interferences (ISI) caused by channel delay spreading under wireless mobile environment. This may cause considerable performance deterioration when the CP length is less than the channel RMS delay spread, or may decrease the system power and spectrum efficiency when it is much larger. A novel OFDM transmission scheme is proposed in this paper to adapt the CP length to the variation of channel delay spread. AOFDM-VCPL utilizes the preamble or pilot sub-carriers of each OFDM packet to estimate the channel RMS delay spread; and then uses a criterion to calculate the CP length , which finally affects the OFDM transmitter. As illustrated in the simulation section, by deploying this scheme in a typical wireless environment, the system can transmit at data rate 11.5 Mb/s higher than conventional non-adaptive system while gaining a 0.65 dB power saving at the same BER performance.
Assessment of clinical significance of positive blood cultures of relatively low-virulence isolates (1996)

In Omori Hospital, Toho University School of Medicine, relatively low-virulence blood isolates, including coagulase-negative staphylococci (CNS), enterococci and nonfermentative gram-negative rods other than Pseudomonas aeruginosa comprised c. 60% of total blood isolates. A retrospective study was conducted to assess their clinical significance by reviewing a total of 91 hospital charts. The physicians' assessments of these positive blood cultures as recorded in the charts were classified into four categories--sepsis, possible sepsis, contamination and no comment. The episodes classified as sepsis accounted for 5.0-19.6%. These episodes were also evaluated by a graded clinical significance score based on multiple factors, including number of positive cultures and clinical signs. The scores for the 91 episodes covered a wide range from 1 to 9, indicating that both contaminants and causative organisms may have been involved. The episodes judged as sepsis or possible sepsis tended to have higher scores. The scores for the episodes associated with enterococci were also higher than those involving CNS or non-fermentative gram-negative rods. The scores for episodes associated with intravenous hyperalimentation catheters were higher than those not associated with the catheters.
Astrocyte regulation of cerebral vascular tone (2013)

Cerebral blood flow is controlled by two crucial processes, cerebral autoregulation (CA) and neurovascular coupling (NVC) or functional hyperemia. Whereas CA ensures constant blood flow over a wide range of systemic pressures, NVC ensures rapid spatial and temporal increases in cerebral blood flow in response to neuronal activation. The focus of this review is to discuss the cellular mechanisms by which astrocytes contribute to the regulation of vascular tone in terms of their participation in NVC and, to a lesser extent, CA. We discuss evidence for the various signaling modalities by which astrocytic activation leads to vasodilation and vasoconstriction of parenchymal arterioles. Moreover, we provide a rationale for the contribution of astrocytes to pressure-induced increases in vascular tone via the vasoconstrictor 20-HETE (a downstream metabolite of arachidonic acid). Along these lines, we highlight the importance of the transient receptor potential channel of the vanilloid family (TRPV4) as a key molecular determinant in the regulation of vascular tone in cerebral arterioles. Finally, we discuss current advances in the technical tools available to study NVC mechanisms in the brain as it relates to the participation of astrocytes.
Correlation of the Avermectin Polyketide Synthase Genes to the Avermectin Structure: Implications for Designing Novel Avermectins (1994)

Streptomyces avermitilis produces a series of eight potent anthelmintic compounds called avermectins (AVM). AVM are pentacyclic, macrocyclic lactone compounds containing an oleandrose disaccharide. Labeling studies have shown that AVM is a polyketide derived from the condensation of 12 acyl units (five propionates and seven acetates) to an isobutyl or 2-methylbutyryl starter unit. The genes required for AVM biosynthesis have been cloned, and deletion mapping has located the AVM gene cluster to a 95-kb region. Partial DNA sequencing of this region indicates two 30-kb segments encode large, multifunctional peptides of the AVM polyketide synthase (PKS). The PKS proteins contain at least 49 domains with homology to the domains in fatty acid synthase and erythromycin PKS. These domains are arranged as 12 modular repeats that each encode a PKS unit with various subsets of the FAS-like functions. The predicted functions required to form the side groups on the AVM macrocyclic ring were compared to the functions found in the 12 PKS units. This comparison suggests that each PKS unit is specific for condensation and reduction of one acyl unit. If the various domains can be manipulated without disrupting the PKS, it may be possible to synthesize a variety of AVM derivatives.
The Use of Flexible Gridding for Improved Reservoir Modeling (1983)

ABSTRACT This paper describes some model improvements developed to allow new possibilities in reservoirs representation with simulators using a finite difference scheme. It includes: possibility of flow between any grid block and from one to many blocks;a multiple time step calculation which allows to solve flow equations with several time step lengths for different group of grid blocks. These facilities provide a flexible and performant way of handling irregular and complex grid patterns with different nested levels of refinements. They are particularly useful to accurately simulate: –unconfined pilots or areas with smaller wells spacing;–faulted reservoirs;–vanishing or discordant geological layers;–reservoirs connected to a general aquifer. The new approach has been tested on a black oil simulator, implicit in pressure, implicit in saturation. The solutions used for some important aspects of model design are outlined. These are the Input/Output data organisation, the inner model grid pattern representation, the matrix solver, the multiple time steps selector and the associated equation solver. Two examples illustrate the use of the modified black oil simulator, and results are presented. The first example concerns the simulation of a repeated five spot injection. This test is made to check the local mesh refinements efficiency. The second example is a full field reservoir study for which using the modified model is suitable. The performance of a produced oil reservoir connected to an aquifer is simulated. In both cases, results obtained with a composite grid and the modified model are compared to those obtained with a coarse grid and then a fine grid used on a conventional model. The following points are outlined: –the use of local grid refinements give results very closed to those obtained with the fine gridded conventional model;–on the computers used, the running time of the modified model simulations is much lower than the time needed for the conventional model. Moreover, it is shown that the modified model results remain unchanged when the multiple time step selector is used. A different time step length is then automatically calculated for the oil reservoir and the aquifer, thus allowing a noticeable extra gain of processing running time.