gebhart/patrepeval huggingface dataset:
Primary and secondary cutaneous CD30+lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment (2000)

To evaluate our diagnostic and therapeutic guidelines, clinical and long-term follow-up data of 219 patients with primary or secondary cutaneous CD30(+) lymphoproliferative disorders were evaluated. The study group included 118 patients with lymphomatoid papulosis (LyP; group 1), 79 patients with primary cutaneous CD30(+) large T-cell lymphoma (LTCL; group 2), 11 patients with CD30(+) LTCL and skin and regional lymph node involvement (group 3), and 11 patients with secondary cutaneous CD30(+) LTCL (group 4). Patients with LyP often did not receive any specific treatment, whereas most patients with primary cutaneous CD30(+) LTCL were treated with radiotherapy or excision. All patients with skin-limited disease from groups 1 and 2 who were treated with multiagent chemotherapy had 1 or more skin relapses. The calculated risk for systemic disease within 10 years of diagnosis was 4% for group 1, 16% for group 2, and 20% for group 3 (after initial therapy). Disease-related 5-year-survival rates were 100% (group 1), 96% (group 2), 91% (group 3), and 24% (group 4), respectively. The results confirm the favorable prognoses of these primary cutaneous CD30(+) lymphoproliferative disorders and underscore that LyP and primary cutaneous CD30(+) lymphomas are closely related conditions. They also indicate that CD30(+) LTCL on the skin and in 1 draining lymph node station has a good prognosis similar to that for primary cutaneous CD30(+) LTCL without concurrent lymph node involvement. Multiagent chemotherapy is only indicated for patients with full-blown or developing extracutaneous disease; it is never or rarely indicated for patients with skin-limited CD30(+) lymphomas. (Blood. 2000;95:3653-3661)
Proteinase‐activated receptors and nociceptive pathways (2003)

Abstract The discovery of Proteinase‐Activated receptors (PARs) in the nervous system has led to new insights about the potential physiological role that these enzymes could play in relation to nerve functions. Here, we summarize evidence that proteinases, through the activation of PARs, interact with the nervous system, playing a role in pain perception and modulation of nociceptive pathways. New potential roles are suggested for the members of the PAR family, highlighting proteinases and their receptors as potential therapeutic targets for pain relief. Drug Dev. Res. 59:382–385, 2003. © 2003 Wiley‐Liss, Inc.
Ultrasensitive, Stretchable Strain Sensors Based on Fragmented Carbon Nanotube Papers (2017)

The development of strain sensors featuring both ultra high sensitivity and high stretchability is still a challenge. We demonstrate that strain sensors based on fragmented single-walled carbon nanotube (SWCNT) paper embedded in poly(dimethylsiloxane) (PDMS) can sustain their sensitivity even at very high strain levels (with a gauge factor of over 10<sup>7</sup> at 50% strain). This record sensitivity is ascribed to the low initial electrical resistance (5-28 Ω) of the SWCNT paper and the wide change in resistance (up to 10<sup>6</sup> Ω) governed by the percolated network of SWCNT in the cracked region. The sensor response remains nearly unchanged after 10 000 strain cycles at 20% proving the robustness of this technology. This fragmentation based sensing system brings opportunities to engineer highly sensitive stretchable sensors.
Colorimetric Visualization of Glucose at the Submicromole Level in Serum by a Homogenous Silver Nanoprism–Glucose Oxidase System (2013)

In this study, we design a homogeneous system consisting of Ag nanoprisms and glucose oxidase (GOx) for simple, sensitive, and low-cost colorimetric sensing of glucose in serum. The unmodified Ag nanoprisms and GOx are first mixed with each other. Glucose is then added in the homogeneous mixture. Finally, the nanoplates are etched from triangle to round by H2O2 produced by the enzymatic oxidation, which leads to a more than 120 nm blue shift of the surface plasmon resonance (SPR) absorption band of the Ag nanoplates. This large wavelength shift can be used not only for visual detection (from blue to mauve) of glucose by naked eyes but for reliable and convenient glucose quantification in the range from 2.0 × 10(-7) to 1.0 × 10(-4) M. The detection limit is as low as 2.0 × 10(-7) M, because the used Ag nanoprisms possess (1) highly reactive edges/tips and (2) strongly tip sharpness and aspect ratio dependent SPR absorption. Owing to ultrahigh sensitivity, only 10-20 μL of serum is enough for a one-time determination. The proposed glucose sensor has great potential in the applications of point-of-care diagnostics, especially for third-world countries where high-tech diagnostics aids are inaccessible to the bulk of the population.
New Attempt in Improving Sweep Efficiency at the Mature Koluel Kaike and Piedra Clavada Waterflooding Projects of the S. Jorge Basin in Argentina (2007)

Proposal Most of the mature waterflood projects at the San Jorge Basin have been affected by two main problems, poor displacement and sweep efficiencies, both have limited the recovery factor achievable. This paper presents a field trial of a new reactive particulate system in an attempt to improve this volumetric sweep efficiency. This particulate system is being used to treat selected injectors operated by Pan American Energy in the Koluel Kaike and Piedra Clavada fields, located in the southern part of Argentina. The main purpose of this field trial is to demonstrate the ability of the new system to improve oil recovery by diversion of injected water into the poorly swept zones around the thief zone or streaks. This state-of-the-art technology is able to propagate deep into thief zones and has a novel mechanism of action to overcome the observed limitations in conventional polymer flooding and gel processes. The particles are manufactured having properties which allow it to propagate through porous media with the injection water. Once in the reservoir and under the influence of heat the particle expands to a size that can block pore throats, so water injected after treatment is diverted into less efficiently swept zones. The paper will describe in detail the mechanism and selection criteria of reservoirs and wells to apply the mentioned IOR technology. Theoretical and practical issues involved at the design of the application, as well as operational and logistics aspects will be also included. Finally, it will include the updated information available from the ongoing pilot tests.
Anomalies: The Winner's Curse (1988)

Next time that you find yourself a little short of cash for lunch, try the following experiment in your class. Take a jar and fill it with coins, noting the total value of the coins. Now auction off the jar to your class (offering to pay the winning bidder in bills to control for penny aversion). Chances are very high that the following results will be obtained: (1) the average bid will be significantly less than the value of the coins (bidders are risk averse); (2) the winning bid will exceed the value of the jar. Therefore, you will have money for lunch, and your students will have learned first-hand about the “winner's curse.” The winner's curse cannot occur if all the bidders are rational, so evidence of a winner's curse in market settings would constitute an anomaly. However, acting rationally in a common value auction can be difficult. Solving for the optimal bid is not trivial. Thus, it is an empirical question whether bidders in various contexts get it right or are cursed. I will present some evidence, both from experimental and field studies, suggesting that the winner's curse may be a common phenomenon.
A Small Mixing-Type Unipolar Charger (SMUC) for Nanoparticles (2010)

A small mixing-type unipolar charger for nanoparticles (SMUC) was developed to increase the charging efficiency and throughput by using a small charging chamber (0.5 cm 3 ) to reduce particle loss caused by electrostatic dispersion. The two main components of the SMUC are a high-pressure corona ionizer (HPC Ionizer) in which high concentration unipolar ions are generated, and a charging chamber in which the unipolar ions are mixed with nanoparticles without an external electric field. The charging performance of the SMUC was evaluated experimentally by measuring the charging ratio fc and the penetration ratio fp . For positive charging in the particle size range of 5–40 nm, fc + = 0.91–0.95 and fp + = 0.71–0.90, at an ion concentration of Ng + = 5.25 10 9 ions/cm 3 and a charging time t R = 0.025 s. For negative charging, f – c = 0.74–0.93 and fp – = 0.73–0.85, at Ng – = 6.24 × 10 9 ions/cm 3 and tR = 0.025 s. Based on these results, the extrinsic charging efficiency defined as fe = fc ×fp /fd (where fd is the dilution rate) was 0.46–0.66 and 0.59–0.71 for negative and positive charging. The and were estimated theoretically with and without electrostatic dispersion to clarify the effect of electrostatic dispersion on particle losses in the charging chamber. The measured fe for dp < 10 nm in the 0.5 cm 3 chamber is higher than the theoretical results without electrostatic dispersion, indicating that particle loss caused by electrostatic dispersion is reduced by use of the small volume charging chamber.
Effects of buried oxide on electrical performance of thin-film silicon-on-insulator metal–oxide–semiconductor field-effect transistor (1999)

Local oxidation of silicon-isolated thin-film silicon-on-insulator (SOI) device characteristics have been investigated in terms of stress in the buried-oxide interface by both simulation and experiment. A bonded SOI wafer with a 400 nm buried oxide and a separation by implanted oxygen SOI wafer with a 100 nm buried oxide are used for device fabrication. In the 100 nm buried-oxide case, boron atoms are accumulated at the silicon side in the interface between the silicon film and oxide (i.e., including the buried oxide and field oxide) due to a highly stressed oxide so that the increased boron concentration increases the threshold voltage of the edge channel. Therefore, it is found that there is no drain current hump in the subthreshold region of thin-film SOI n-channel metal–oxide–semiconductor field-effect transistors with 100 nm buried oxide. From the simulation, it is demonstrated that the 100 nm buried oxide has higher compressive stress than the 400 nm counterpart after the local oxidation of silicon process.
Preparation of SiO <sub>2</sub> Glass from Model Powder Compacts: III, Enhanced Densification by Sol Infiltration (1988)

Highly ordered powder compacts were formed using spherical, nearly monosized, amorphous SiO 2 particles. Some of these compacts were subsequently infiltrated with a “silica’sol. After drying, the powder compact interstices contained small, porous xerogel particles, thereby increasing the green relative density of the compact. Sintering studies showed a significant enhancement in densification for the sol‐infiltrated samples.
Comparing the Ground Resistivity Measured by DC and Capacitively-coupled Resistivity Methods (2013)

The Capacitively-Coupled (CC) resistivity method is an emerging geophysical technique for near surface investigations. Compared with the conventional Direct Current (DC) resistivity method, the CC resistivity method can be used with less restrictions and time consumption because there is no need to install steel electrodes. However, discrepancy in the measured apparent resistivity between the DC and CC resistivity methods can be found. Field measurements in this study demonstrate that if the arrays used in the DC and CC resistivity methods have a similar sensitivity function, i.e., similar depthinvestigation characteristics, the measured apparent resistivity from the two methods is comparable and vice versa. In addition, the gap effect in the CC resistivity methods using OhmMapper can produce errors that cannot be simply ignored if the ground surface is very rough. © 2013 Taylor & Francis Group.
Endogenous Rhythm in Opening and Closing of Flowers in Portulaca-D-Spp (1971)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Bilayer curvature and certain amphipaths promote poly(ethylene glycol)-induced fusion of dipalmitoylphosphatidylcholine unilamellar vesicles (1992)

Unilamellar vesicles of varying and reasonably uniform size were prepared from 1,2-dipalmitoyl-3-sn-phosphatidylcholine (DPPC) by the extrusion procedure and sonication. Quasi-elastic light scattering was used to show that different vesicle preparations had mean (Z-averaged) diameters of 1340, 900, 770, 630, and 358 A (sonicated). Bilayer-phase behavior as detected by differential scanning calorimetry was consistent with the existence of essentially uniform vesicle populations of different sizes. The response of these different vesicles to treatment with poly(ethylene glycol) (PEG) was monitored using fluorescence assays for lipid transfer, contents leakage, and contents mixing, as well as quasi-elastic light scattering. No fusion, as judged by vesicle contents mixing and change in vesicle size, was detected for vesicles of diameter greater than 770 A. The diameters of smaller vesicles increased dramatically when treated with high concentrations of PEG, although mixing of their contents could not be detected both because of their small trapped volumes and because of the extensive leakage induced in small vesicles by high concentrations of PEG. Lipid transfer was detected between vesicles of all sizes. We conclude the high bilayer curvature does encourage fusion of closely juxtaposed membrane bilayers but that highly curved vesicles appear also to rupture and form larger structures when diluted from high PEG concentration, a process that can be confused with fusion. Despite the failure of PEG to induce fusion of large, uncurved vesicles composed of a single phosphatidylcholine, these vesicles can be induced to fuse when they contain small amounts of certain amphiphathic compounds thought to play a role in cellular fusion processes. Thus, vesicles which contained 0.5 mol % L-alpha-lysopalmitoylphosphatidylcholine, 5 mol % platelet activating factor, or 0.5 mol % palmitic acid fused in the presence of 30%, 25%, and 20% (w/w) PEG, respectively. However, vesicles containing 1,2-dipalmitoyl-sn-glycerol, 1,2-dioleoyl-sn-glycerol, 1-oleoyl-2-acetyl-sn-glycerol, or monooleoyl-rac-glycerol at surface concentrations up to 5 mol % did not fuse in the presence or absence of PEG. There was no correlation between the abilities of these amphipaths to induce phase separation or nonlamellar phases and their abilities to support fusion of pure DPPC unilamellar vesicles in the presence of high concentrations of PEG. The results are discussed in terms of the type of disrupted lipid packing that could be expected to favor PEG-mediated fusion.
Acid hydrolysis of carboxylic esters in a two-phase system in the presence of catalytic amounts of quaternary onium salts. Mild and selective cleavage of tert-butyl esters (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcid hydrolysis of carboxylic esters in a two-phase system in the presence of catalytic amounts of quaternary onium salts. Mild and selective cleavage of tert-butyl estersDario Landini and Franco RollaCite this: J. Org. Chem. 1982, 47, 1, 154–156Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/jo00340a037https://doi.org/10.1021/jo00340a037research-articleACS PublicationsRequest reuse permissionsArticle Views651Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bonding of Co Ions in ZSM-5, Ferrierite, and Mordenite:  An X-ray Absorption, UV−Vis, and IR Study (2002)

Coordination and bonding of Co ions at cationic sites in zeolites of ZSM-5, FER, and MOR structures were investigated by X-ray absorption and by UV−Vis and FTIR spectroscopy. Co(II) ions, exchanged under conditions in which no hydrolysis took place, were coordinated exclusively to framework oxygen atoms; no Co−O−Co bridging structures were found. Three types of Co ion coordination and three types of perturbation of the framework T−O bonds at the corresponding cationic sites were distinguished by Vis spectra of the Co(II) ions and IR spectra of skeletal vibrations. EXAFS and FTIR showed that Co ion bonding at exchangeable sites of pentasil ring zeolites requires substantial deformation of the adjacent framework T−O bonds to attain coordination to four or three framework oxygens with Co−O bond distances of 1.99 to 2.06 Å. Such coordination is possible only with certain cationic site structures α, β, and γ, which are very similar for ZSM-5, ferrierite, and mordenite. Slight differences in these local framework structures lead to different perturbation of the framework bonds at the individual cationic sites. To satisfy the bonding requirements of the Co ions, the sequence of the extent of perturbation of framework bonds is MOR > ZSM-5 > FER.
Cross-correlation Based Compression Techniques for Frequency Modulated Thermal Wave Imaging (2010)

Infrared non destructive testing (NDT) with recently proposed frequency modulated thermal wave imaging, launches thermal waves with significant energy in the desired band of frequencies, decided by sample thermal characteristics and its dimensions, in the object under test. Pulse compression based post processing enhances the defect detection capability of the above scheme even with moderate peak power excitation sources. This contribution highlights the applicability of the correlation based pulse compression scheme for investigation of defects like voids, inclusions and cracks and comparison has been made with existing phase based analysis.
A direct interaction between TGFβ activated kinase 1 and the TGFβ type II receptor: Implications for TGFβ signalling and cardiac hypertrophy (2005)

We describe a novel and specific interaction between TAK1 and TBRII which, for the first time, directly links TAK1 to the TGFbeta signalling cascade and potentially explains how TGFbeta signalling in cardiomyocytes mediates a hypertrophic response.
In Vivo RNA Interference Analysis Reveals an Unexpected Role for GNBP1 in the Defense against Gram-positive Bacterial Infection in Drosophila Adults (2004)

The Drosophila immune system discriminates between different classes of infectious microbes and responds with pathogen-specific defense reactions via the selective activation of the Toll and the immune deficiency (Imd) signaling pathways. The Toll pathway mediates most defenses against Gram-positive bacteria and fungi, whereas the Imd pathway is required to resist Gram-negative bacterial infection. Microbial recognition is achieved through peptidoglycan recognition proteins (PGRPs); Gram-positive bacteria activate the Toll pathway through a circulating PGRP (PGRP-SA), and Gram-negative bacteria activate the Imd pathway via PGRP-LC, a putative transmembrane receptor, and PGRP-LE. Gram-negative binding proteins (GNBPs) were originally identified in Bombyx mori for their capacity to bind various microbial compounds. Three GNBPs and two related proteins are encoded in the Drosophila genome, but their function is not known. Using inducible expression of GNBP1 double-stranded RNA, we now demonstrate that GNBP1 is required for Toll activation in response to Gram-positive bacterial infection; GNBP1 double-stranded RNA expression renders flies susceptible to Gram-positive bacterial infection and reduces the induction of the antifungal peptide encoding gene Drosomycin after infection by Gram-positive bacteria but not after fungal infection. This phenotype induced by GNBP1 inactivation is identical to a loss-of-function mutation in PGRP-SA, and our genetic studies suggest that GNBP1 acts upstream of the Toll ligand Spätzle. Altogether, our results demonstrate that the detection of Gram-positive bacteria in Drosophila requires two putative pattern recognition receptors, PGRP-SA and GNBP1.
A novel electron tunneling infrared detector (1990)

The pneumatic infrared detector, originally developed by Golay in the late 1940s, uses the thermal expansion of one cm(exp 3) of xenon at room temperature to detect the heat deposited by infrared radiation. This detector was limited by thermal fluctuations within a 10 Hz bandwidth, but suffered from long thermal time constants and a fragile structure. Nevertheless, it represents the most sensitive room temperature detector currently available in the long wavelength infrared (LWIR). Fabrication of this type of detector on smaller scales has been limited by the lack of a suitably sensitive transducer. Researchers designed a detector based on this principle, but which is constructed entirely from micromachined silicon, and uses a vacuum tunneling transducer to detect the expansion of the trapped gas. Because this detector is fabricated using micromachining techniques, miniaturization and integration into one and two-dimensional arrays is feasible. The extreme sensitivity of vacuum tunneling to changes in electrode separation will allow a prototype of this detector to operate in the limit of thermal fluctuations over a 10 kHz bandwidth. A calculation of the predicted response and noise of the prototype is presented with the general formalism of thermal detectors. At present, most of the components of the prototype have been fabricated and tested independently. In particular, a characterization of the micromachined electron tunneling transducer has been carried out. The measured noise in the tunnel current is within a decade of the limit imposed by shot noise, and well below the requirements for the operation of an infrared detector with the predicted sensitivity. Assembly and characterization of the prototype infrared detector will be carried out promptly.
Potential Drug Interaction With Paclitaxel and Highly Active Antiretroviral Therapy in Two Patients With AIDS-Associated Kaposi Sarcoma (2004)

Highly active antiretroviral therapy (HAART) consisting of multiple combinations of antiretroviral agents that inhibit HIV (HIV) replication has been associated with improvements in CD4+ T-lymphocyte cell counts, suppression of HIV replication, and regression of HIV-associated Kaposi's sarcoma (KS). Several of these agents have complex drug-drug interactions and have the potential to aggravate paclitaxel-associated toxicities. Herein two patients with KS are described who received paclitaxel while on HAART and who developed life-threatening toxicities. These cases are presented to alert clinicians to potentially serious drug interactions that can occur between various components of HAART and paclitaxel. Clinicians contemplating taxane-based chemotherapy for HIV-associated KS should carefully monitor patients for adverse events and, depending on their patient's HAART regimen, consider reducing the taxane dose.