gebhart/patrepeval huggingface dataset:
Sweep-Improvement Options for the Daqing Oil Field (2008)

Summary This paper investigates the potential of various approaches for improving sweep in parts of the Daqing oil field that have been enhanced-oil-recovery (EOR) targets. Our studies indicated that the polymer flood should have provided excellent sweep throughout the vast majority of the patterns under consideration. However, because alkaline/surfactant/polymer (ASP) flooding is being considered to increase recovery efficiency from the Daqing oil field, mobility control and sweep improvement will be especially important and challenging during implementation of any future ASP process. Fractures were present in a number of Daqing wells (both injectors and producers). Because the fractures were narrow and far from the wellbore, severe channeling did not occur. On the contrary, fractures near the wellbore aided reservoir sweep. Nearwellbore fractures increased the injectivity index substantially during the injection of polymer solutions and increased oil-productivity index in the production wells. These observations may be valuable during implementation of future floods where very-low-mobility chemical (i.e., ASP) banks must be injected to maintain mobility control. Several modes of polymer degradation were considered, with mechanical (shear) degradation being of greatest concern. Appropriate use of near-wellbore fractures may mitigate mechanical degradation effectively, as well as improving injectivity. Several new polymers show potential for cost-effective improvements at Daqing. Increased polymer concentration was also considered. A number of other approaches are (or have been) under investigation, including colloidal dispersion gels, foams, ASP foams, steam, microbes, and polymer solutions prepared with reduced salinity.
Tumour suppressive properties of the adenovirus 5 E1A oncogene. (1996)

The transforming oncogenes of DNA tumour viruses have proven useful as tools to dissect the mechanisms of complex cellular processes. In particular, studies of the multifunctional proteins encoded by the early region 1A (E1A) of human adenovirus types 2 and 5 have provided insight into the regulation of cellular gene expression, growth and differentiation. Despite their well known ability to immortalize primary rodent cells and transform them in cooperation with a second oncogene, the E1A proteins also exhibit significant anti-tumour/tumour suppressive activity. This review focuses on the surprising ability of E1A to function as a tumour suppressor gene.
Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura (2017)

Safety, tolerability, and pharmacokinetics of recombinant ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; BAX 930; SHP655) were investigated in 15 patients diagnosed with severe congenital ADAMTS-13 deficiency (plasma ADAMTS-13 activity <6%) in a prospective phase 1, first-in-human, multicenter dose escalation study. BAX 930 was well tolerated, no serious adverse events occurred, and no anti-ADAMTS-13 antibodies were observed. After single-dose administration of BAX 930 at 5, 20, or 40 U/kg body weight to adolescents and adults, there was approximate dose proportionality with respect to maximum plasma concentration (C<sub>max</sub> [U/mL]) and area under the concentration-time curve (AUC [h∙U/mL]). Dose-related increases of individual ADAMTS-13:Ag and activity were observed and reached a maximum within 1 hour. With escalating BAX 930 doses administered, a dose-dependent persistence of ADAMTS-13-mediated von Willebrand factor (VWF) cleavage products and reduced VWF multimeric size were observed. This study demonstrated that pharmacokinetic parameters of BAX 930 were comparable to those estimated in previous plasma infusion studies and provided evidence of pharmacodynamic activity. This study was registered at www.clinicaltrials.gov as #NCT02216084.
Patterned growth of coiled carbon nanotubes by a template-assisted technique (2003)

A method for controlled synthesis of coiled carbon nanotubes (CNTs) is demonstrated, in which three-dimensional columns of aligned CNTs are used as a template. The coiled CNTs with pitches and coil diameters from 100 to 300 nm are regrown on the straight CNT arrays and the mesoporous structure between the CNT arrays produces an asymmetric growth condition for the coil formation. As observed using transmission electron microscopy, the graphitic layers on the tube wall are stacking-disordered due to the coil geometry. The growth mechanism of the coiled CNTs is also proposed.
VASCULAR ENDOTHELIAL GROWTH FACTOR IS INCREASED DURING THE FIRST 48 HOURS OF HUMAN SEPTIC SHOCK AND CORRELATES WITH VASCULAR PERMEABILITY (2005)

Meningococcal septic shock is an important cause of morbidity and mortality in children and young adults worldwide and is the prototypical gram-negative septic shock. One of the key factors in the development of shock is increased microvascular permeability. Vascular endothelial growth factor (VEGF) is a central factor in angiogenesis and is an important mediator of vascular permeability. Thirteen patients with meningococcal infection (eight presenting with shock) were investigated in the early phase of invasive meningococcal disease. Cytokines, complement activation, and VEGF plasma concentrations were measured during the first 48 h on the pediatric intensive care unit. Increased cytokine concentrations and activation of the complement system were observed. VEGF plasma concentrations were increased (median 193 pg/mL, range 71-1082) and were highest in the presence of shock (208 pg/mL, 169-1082) compared with patients presenting without shock (92 pg/mL range 71-299). VEGF concentration at admission correlated with the severity of disease (pediatric risk of mortality score, R=0.90 [Spearman], P=0.0001) and the amount of fluids administered within the first 24 h (R=0.90, P<0.0001). In all patients, a decrease in VEGF was associated with a decrease in fluid intake during t=24 to 48 h. The results suggest that apart from correlation with IL-1 beta, -10, -12, and complement activation, microvascular permeability in sepsis is also closely linked to the plasma concentration of VEGF. The role of VEGF in sepsis-associated increased microvascular permeability needs further exploration and may represent a new therapeutic target.
Adaptive Synthesis of Distance Fields (2011)

We address the computational resource requirements of 3D example-based synthesis with an adaptive synthesis technique that uses a tree-based synthesis map. A signed-distance field (SDF) is determined for the 3D exemplars, and then new models can be synthesized as SDFs by neighborhood matching. Unlike voxel synthesis approach, our input is posed in the real domain to preserve maximum detail. In comparison to straightforward extensions to the existing volume texture synthesis approach, we made several improvements in terms of memory requirements, computation times, and synthesis quality. The inherent parallelism in this method makes it suitable for a multicore CPU. Results show that computation times and memory requirements are very much reduced, and large synthesized scenes exhibit fine details which mimic the exemplars.
Navigated control in functional endoscopic sinus surgery (2005)

This study designs and evaluates a mechatronic system to assist ENT surgery, taking as an example a navigation controlled shaver as used in paranasal sinus surgery. The on/off status of the shaver is regulated automatically, depending on the current position of the shaver tip. The working space for the navigation controlled shaver is planned preoperatively as a three-dimensional model and is based on the individual patient's CT data. Within this area the shaver reacts to signals from the surgeon. If the tip of the shaver moves outside the predefined working space, the shaver's automatic drive control is interrupted by an electrical pulse. The planning software was evaluated using CT data sets from 32 patients. The accuracy of the registration was analysed on an anatomical model with the aid of 451 measurements on titanium screws attached endonasally, whilst the implementation of the working space was evaluated on 5 technical models. The average time taken for segmenting the working space was found to be 4.23 minutes. The average accuracy of the shaver registration was 1.08 mm. The selected cavity was to be resected without any restrictions. The preoperatively determined working space was implemented with a mean deviation of 3.1 mm over all levels. The study proves the feasibility of a mechatronic assistance system taking as an example the navigation controlled shaver used in paranasal sinus surgery. In contrast to isolated CAS solutions, this conceptual approach provides for the redundancy of the surgeon and eases their cognitive burden. We can foresee numerous applications in ENT surgery of the future following the principle presented here, in the control systems of power tools such as cutters, high frequency scalpels and lasers.
Fusion of possible biased local estimates in sensor network based on sensor selection (2013)

The paper addresses the problem of estimation fusion in sensor network, in the presence of possible biased local estimates. A sensor selection-based fusion scheme is presented to deal with this problem, which seek to select a subset of sensors to be fused, for the purpose of achieving a better estimation performance. Firstly, we introduce an optimization criterion over any given subset of sensors based on the similarity measure among local estimates. Secondly, we invoke the cross entropy (CE) method to solve the resulting combinatorial optimization problems. We also explore the efficiency and performance of the proposed approach via simulation experiments, compared with other recently proposed techniques.
Shotgun Proteomic Analysis Unveils Survival and Detoxification Strategies by<i>Caulobacter crescentus</i>during Exposure to Uranium, Chromium, and Cadmium (2014)

The ubiquitous bacterium Caulobacter crescentus holds promise to be used in bioremediation applications due to its ability to mineralize U(VI) under aerobic conditions. Here, cell free extracts of C. crescentus grown in the presence of uranyl nitrate [U(VI)], potassium chromate [Cr(VI)], or cadmium sulfate [Cd(II)] were used for label-free proteomic analysis. Proteins involved in two-component signaling and amino acid metabolism were up-regulated in response to all three metals, and proteins involved in aerobic oxidative phosphorylation and chemotaxis were down-regulated under these conditions. Clustering analysis of proteomic enrichment revealed that the three metals also induce distinct patterns of up- or down-regulated expression among different functional classes of proteins. Under U(VI) exposure, a phytase enzyme and an ABC transporter were up-regulated. Heat shock and outer membrane responses were found associated with Cr(VI), while efflux pumps and oxidative stress proteins were up-regulated with Cd(II). Experimental validations were performed on select proteins. We found that a phytase plays a role in U(VI) and Cr(VI) resistance and detoxification and that a Cd(II)-specific transporter confers Cd(II) resistance. Interestingly, analysis of promoter regions in genes associated with differentially expressed proteins suggests that U(VI) exposure affects cell cycle progression.
The design of a system for designing knowledge representation systems (1981)

The use of abstract data types as a basis for designing experimental knowledge representation systems is discussed. Abstract data types are shown to have features in common with severel diverse representation formalisms (e.g. semantic networks, frames and KLONE). For example, abstract data types have notions analogous to concept, subconcept and inheritance. The relatively small conceptual distance between abstraect data types and knowledge representation formalisms make them an ideal vehicle for implementing such formalisms.
Identification of potential diagnostic biomarkers for Parkinson's disease (2019)

The identification of biomarkers for early diagnosis of Parkinson's disease (PD) prior to the onset of symptoms may improve the effectiveness of therapy. To identify potential biomarkers, we downloaded microarray datasets of PD from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between PD and normal control (NC) groups were obtained, and the feature selection procedure and classification model were used to identify optimal diagnostic gene biomarkers for PD. A total of 1229 genes (640 up-regulated and 589 down-regulated) were obtained for PD, and nine DEGs (PTGDS, GPX3, SLC25A20, CACNA1D, LRRN3, POLR1D, ARHGAP26, TNFSF14 and VPS11) were selected as optimal PD biomarkers with great diagnostic value. These nine DEGs were significantly enriched in regulation of circadian sleep/wake cycle, sleep and gonadotropin-releasing hormone signaling pathway. Finally, we examined the expression of GPX3, SLC25A20, LRRN3 and POLR1D in blood samples of patients with PD by qRT-PCR. GPX3, LRRN3 and POLR1D exhibited the same expression pattern as in our analysis. In conclusion, this study identified nine DEGs that may serve as potential biomarkers of PD.
Acerca de la Situación Actual de la Teoría Económica (1996)

The presence of ascites in patients with liver cirrhosis is associated with increased plasmatic fibrinolytic activity. Less aggressive ascites resolution therapy has an greater impact on reducing plasmatic fibrinolytic activity than achieved by abdominal paracenthesis.
Lanthanide-Assisted Deposition of Strongly Electro-optic PZT Thin Films on Silicon: Toward Integrated Active Nanophotonic Devices (2015)

The electro-optical properties of lead zirconate titanate (PZT) thin films depend strongly on the quality and crystallographic orientation of the thin films. We demonstrate a novel method to grow highly textured PZT thin films on silicon using the chemical solution deposition (CSD) process. We report the use of ultrathin (5-15 nm) lanthanide (La, Pr, Nd, Sm) based intermediate layers for obtaining preferentially (100) oriented PZT thin films. X-ray diffraction measurements indicate preferentially oriented intermediate Ln2O2CO3 layers providing an excellent lattice match with the PZT thin films grown on top. The XRD and scanning electron microscopy measurements reveal that the annealed layers are dense, uniform, crack-free and highly oriented (>99.8%) without apparent defects or secondary phases. The EDX and HRTEM characterization confirm that the template layers act as an efficient diffusion barrier and form a sharp interface between the substrate and the PZT. The electrical measurements indicate a dielectric constant of ∼650, low dielectric loss of ∼0.02, coercive field of 70 kV/cm, remnant polarization of 25 μC/cm(2), and large breakdown electric field of 1000 kV/cm. Finally, the effective electro-optic coefficients of the films are estimated with a spectroscopic ellipsometer measurement, considering the electric field induced variations in the phase reflectance ratio. The electro-optic measurements reveal excellent linear effective pockels coefficients of 110 to 240 pm/V, which makes the CSD deposited PZT thin film an ideal candidate for Si-based active integrated nanophotonic devices.
Stable Free-Radical Emulsion Polymerization (2004)

Polymerizations of styrene under emulsion stable free-radical polymerization conditions are reported. Precipitation of an acetone solution of a low molecular weight TEMPO-terminated polystyrene into an aqueous solution of poly(vinyl alcohol) enables the formation of emulsion particles that can be swollen with monomer and subsequently polymerized. The polymerizations proceed in a living manner, yielding polymers that show an incremental increase in molecular weight with time and have narrow molecular weight distributions. Plots of number-average molecular weight versus conversion are linear, indicating a controlled polymerization. The resulting latexes are colloidally stable, and particle size distributions are Gaussian with an average particle diameter of 450 nm. These results constitute the first successful example of an SFRP emulsion process in which the product is not contaminated with a conventionally produced broad molecular weight distribution polymer.
Using the Semantic Web and Web Apps to Connect Radiologists and Oncologists (2012)

Medical imaging plays an important role in the diagnosis, prognosis and treatment of cancer. Quantitative and qualitative data about medical images are vital components of a radiological report and are very important to the oncologist that requests the radiological exams. However, traditional methods to register these data are inefficient and error prone. The use of unstructured free text in radiology reports makes it impossible to perform even simple calculations, such as changes in lesion dimensions. It also makes the aggregated analysis of many reports difficult. Free text reports lack a reference to the image regions of the finds they refer to and are not machine-computable. This paper proposes a method to provide support for collaborative work among radiologists and oncologists (providing care or taking part in clinical trials) using an imaging web tool, ePAD, to generate structured radiology reports that can be machine-computable. It also shows how ePAD uses Rad Lex ontology terms and the Annotation and Image Markup (AIM) language (and templates) to generate the reports.
Creating the invisible interface (1994)

For thirty years, most interface design, and most computer design, has been headed down the path of the “dramatic” machine. Its highest ideal is to make a computer so exciting, so wonderful so interesting, that we never want to be without it. A less-traveled path I call the “invisible”; its highest ideal is to make a computer so imbedded, so fitting, so natural, that we use it without even thinking about it. (I have also called this notion “Ubiquitous Computing.”) I believe that in the next twenty years the second path will come to dominate. But this will not be easy; very little of our current systems infrastructure will survive. We have been building versions of the infrastructure-to-come at PARC for the past four years, in the form of inch-, foot-, and yard-sized computers we call Tabs, Pads, and Boards. In this talk I will describe the humanistic origins of the “invisible” ideal in post-modernist thought. I will then describe some of our prototypes, how they succeed and fail to be invisible, and what we have learned. I will illustrate new systems issues that user interface designers will face when creating invisibility. And I will indicate some new directions we are now exploring, including the famous “dangling string” display.
Reading Comprehension Strategy Instruction and Attribution Retraining for Secondary Students With Learning and Other Mild Disabilities (2011)

A pre-post experimental design with 6-week delayed posttest was implemented to investigate the effects of reading comprehension strategy (RCS) instruction with and without attribution retraining (AR) on reading outcomes for seventh, eighth, and ninth graders with learning and other mild disabilities. Students were randomly assigned to one of three treatments: RCS+AR, RCS, or a Read Naturally (Ihnot, 1992) comparison condition. Results indicated that compared to the comparison group, both strategy instruction groups performed better on a summarization measure of comprehension after treatment producing large effect sizes. Both groups also performed better after a 6-week delay; however, only the RCS+AR group maintained a large effect size. In addition, RCS+AR students displayed higher attributions for reading success at post- and delayed posttesting. Implications for practice and future research are discussed.
Low Temperature Catalytic Adsorption of SO<sub>2</sub> on Activated Carbon (2008)

Catalytic adsorption of SO2 on activated carbon materials provides an appropriate alternative for the control of low concentration emissions of this air pollutant. The surface complexes formed upon SO2 adsorption at 30 °C were studied by X-ray photoelectron spectroscopy (XPS) and temperature-programmed desorption (TPD). The effect of the addition of O2 and the presence of copper as catalyst were studied. Copper assisted the oxygen transfer to the carbon matrix. For the Cu-impregnated carbon sample, the presence of O2 favored SO2 adsorption by increasing the breakthrough time, the adsorption capacity and the formation of sulfur and oxygen complexes of higher thermal stabilities, which mainly desorb as SO2 and CO2.
Artifact and Fact of Si(111)7×7 Surface Images Observed with a Low Temperature Noncontact Atomic Force Microscope (LT-NC-AFM) (2001)

We investigate Si(111)7×7 surface by using a low temperature noncontact atomic force microscope (LT-NC-AFM). We obtain two types of AFM images with and without an additional structure between the corner and center adatoms. The distance between the corner adatom and additional structure is 7.0 Å±0.2 Å, which is not consistent with that (4.3 Å) between the corner adatom and the rest atom. This suggests that the additional structure observed is an artifact. We propose a model to explain these experimental results, which is based on atomic arrangement of the Si tip apex with an asymmetric ad-dimer and the Si(111)7×7 surface.
Der Frühverschluß des Ductus arteriosus mit Indomethazin* (1985)

The open ductus arteriosus was closed with indomethacin on the first days of life in 13 out of 27 preterm infants with respiratory distress syndrome. The early medical closure of the ductus arteriosus shortened the duration of the ventilatory assistance and need of additional oxygen in these infants.
Color-Naming Defects in Association With Alexia (1966)

DISTURBANCES of color identification in association with the syndrome of pure alexia without agraphia have been repeatedly recognized in the past. Lange<sup>1</sup>reviewed these extensively. More recently Critchley<sup>2</sup>has reviewed the literature on such disturbances of color identification. He expressed skepticism as to the existence of the syndrome of aphasia for color names and advanced the view that such cases probably represented the combination of a perceptual deficit with a minimal aphasia. We have recently had the opportunity to clarify the problem of color-name aphasia by repeated study of a patient with the syndrome of pure alexia without agraphia over several months. On the basis of these studies, we believe that the evidence is now clear that a disturbance of color-naming, or more correctly, of matching the spoken name of the color to the seen color, can be shown to exist in the demonstrated absence of any
HERA: A reconfigurable and mixed-mode parallel computing engine on platform FPGAs (2004)

In this study Misoprostol proved to be a safe and effective drug to use for induction of labour (IOL). Vaginal route was more efficacious compared to the oral route. A slightly higher number of patients in the vaginal group had hyper stimulation and neonates required NICU admission.
Ocular Tissue Distribution in Rabbit after Instillation of Bromfenac Sodium Ophthalmic Solution. (1999)

14C-プロムフェナクナトリウム点眼液を雄性白色ウサギの両眼に0.1mg/animal(0,05mg/50μl/eye)の割合で単回あるいは反復点眼投与し，吸収，分布および代謝について検討した． 1．単回点眼後における血漿中放射能濃度は投与後30分に最高濃度113.2ng eq./mlを示したのち，1時間から12時間まで半減期2.2hrで消失した．眼組織内放射能濃度は約半数の組織が投与後30分に最高濃度を示した．組織への分布は角膜に最も高い濃度が認められ，ついで前部強膜および結膜に高かった．水晶体および硝子体の濃度は最も低かった．投与後72時間では水晶体で最高濃度の7%を示したものの，他の組織ではすべて検出限界以下であった． 2．反復点眼期間中における血漿中放射能濃度は1回投与後24時間では検出限界以下であったが，7回投与以降，投与回数に伴って緩慢に上昇し，21回投与までにほぼ定常状態に達した．また1，7，14および21回投与後24時間の眼組―織内放射能濃度は一部の組織を除いて投与回数に伴って上昇したが，21回投与までにほぼ定常状態に達した．水晶体および後部強膜では21回投与後には1回投与後の4.0および1.6倍の濃度を示した．21回投与後の血漿および眼組織からの放射能の消失は単回投与群と比較してやや緩慢であった． 3．単回点眼後1，2および4時間に得られた前房水中には未変化体が前房水中放射能の73.0～79.5%が認められた．代謝物としてプロムフェナクのcarboxymethyl基が酸化されてbenzoic acid誘導体に変換されたAHR-11665およびその前駆体であるWAY-127039-A-1，また分子内環化して2-oxyindole誘導体に変換されたAHR-10240およびisatine誘導体のAHR-11652が検出された．血漿中には単回点眼後1，2および4時間に未変化体が血漿中放射能の76.7～80.5%が認められた．代謝物として前房水中に認められた代謝物のほか，未知代謝物1RaP1，1RaP2および1RaP3が検出された．