gebhart/patrepeval huggingface dataset:
Static VAr compensator (STATCOM) based on single-phase chain circuit converters (1998)

Voltage-sourced converter circuits using gate turn-off (GTO) thyristors have been proposed as an alternative means of providing static VAr compensation (SVC). Such ‘advanced SVCs’ are classified under the nomenclature STATCOM (STATic COMpensator). The published converter circuits suitable for power system application include the classical Graetz bridge and the multilevel converter. An alternative circuit arrangement has been developed with significant advantages in terms of cost and performance; this is in the form of a number of GTO converter links connected in series to form a chain and is referred to as a chain circuit converter. The paper discusses the chain circuit converter and its application to VAr compensation, followed by the design and simulated performance of a 3-phase STATCOM under both steady state and transient operating conditions. The technical advantages of the chain circuit converter compared with other known arrangements of STATCOM are given. These include good harmonic performance, fast response and improved output at low voltage compared with conventional SVCs. The paper includes comments on the successful testing of two prototype chain links for both leading and lagging reactive currents up to 2000 A peak and concludes with a description of the equipment now being designed for commercial service.
Progressive Metamorphism of Siliceous Limestone and Dolomite (1940)

The metamorphism of siliceous dolomitic limestone is considered with the aid of a composition tetrahedron which suggests that the changes may be referred to thirteen steps or grades of increasing decarbonation, taking place at successively higher temperatures at any given pressure. At the temperature appropriate to each step a certain phase assemblage becomes unstable and each step is characterized by the disappearance of its appropriate phase assemblage. The survival of that phase assemblage in a rock is rigorously indicative of the fact that the step in question has not been attained. In most of the steps, to wit ten, the disappearance of its phase assemblage is accompanied by a more conspicuous phenomenon, the appearance of a new phase, a meta-morphic mineral, but this appearance of a new phase cannot be regarded as rigorously indicative of the accomplishment of the step since the new phase can be produced otherwise. Nevertheless, if certain additional conditions are fulfilled, the new phase will appear only when the temperature of the appropriate step is attained and the metamorphic minerals then become indicators of grade of metamorphism. In the order of the rising temperature steps at which they are produced the ten minerals are tremolite, forsterite, diopside, periclase, wollastonite, monticellite, akermanite, spurrite, merwinite, and larnite. Examination of their natural occurrence suggests that they are for the most part produced under conditions which permit their use as temperature indicators.
Direct synthesis of optimized DSP assembly code from signal flow block diagrams (1992)

Block diagrams with signal flow semantics have proven their utility in system simulation and algorithm development. They can also be used as high-level languages for real-time system implementation and design. An approach to synthesizing optimized assembly code for programmable DSPs from block diagrams is described. The extensible block library defines code segments in a meta-assembly language that uses the syntax of the assembly code of the target processor, but symbolically references registers and memory. An optimizing code generator compiles these segments together, allocates registers and memory, and inserts data movement instructions as needed to produce optimized assembly code. In exchange for target-processor dependence in both the code generator and the block library, the system produces assembly code that can closely match the efficiency of hand-written code.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Attachment and spreading of human gingival fibroblasts on potentially bioactive glasses <i>in vitro</i> (1988)

The attachment and spreading of cultured fibroblasts on potentially bioactive glasses (bioglasses) of ten different compositions were studied. Human gingival fibroblasts were allowed to attach and spread on bio-glasses for 1-72 h. Unreactive silica glass and cell culture polystyrene served as controls. The attachment and spreading of cells were examined by 3H-thymidine labeling of cells, planimetric analysis, cytological staining, immunocytochemistry, and scanning electron microscopy. The cell attachment to bioglasses and silica glass and the cell spreading on bioglasses were slower and cell morphology more elongated compared to control plastic. In spite of great differences in bioglass compositions no great differences in cell behavior on these surfaces were detected. Thus the initial events in the tissue-implant interface might be independent on the bioglass composition, and furthermore the differences in the organization of the tissue-implant interface in vivo might depend on the nature of the surrounding tissues and subsequent changes of the implant surface and the extracellular environment.
Highly potent metallopeptide analogues of luteinizing hormone-releasing hormone. (1989)

Metal complexes related to the cytotoxic complexes cisplatin [cis-diamminedichloroplatinum(II)] and transbis(salicylaldoximato)copper(II) were incorporated into suitably modified luteinizing hormone-releasing hormone (LH-RH) analogues containing D-lysine at position 6. Some of the metallopeptides thus obtained proved to be highly active LH-RH agonists or antagonists. For instance, SB-40, a PtCl2-containing metallopeptide in which platinum is coordinated to an N epsilon-(DL-2,3-diaminopropionyl)-D-lysine residue [D-Lys(DL-A2pr] at position 6, showed 50 times higher LH-releasing potency than the native hormone. SB-95, [Ac-D-Nal(2)1,D-Phe(pCl)2, D-Pal(3)2, Arg5,D-Lys[DL-A2pr(Sal2Cu)]6,D-Ala10]LH-RH, where Nal(2) is 3-(2-naphthyl)alanine, Pal(3) is 3-(3-pyridyl)alanine, and copper(II) is coordinated to the salicylideneimino moieties resulting from condensation of salicylaldehyde with D-Lys(DL-A2pr)6, caused 100% inhibition of ovulation at a dose of 3 micrograms in rats. Most metallopeptide analogues of LH-RH showed high affinities for the membrane receptors of rat pituitary and human breast cancer cells. Some of these metallopeptides had cytotoxic activity against human breast cancer and prostate cancer cell lines in vitro (this will be the subject of a separate paper on cytotoxicity evaluation). Such cytostatic metallopeptides could be envisioned as targeted chemotherapeutic agents in cancers that contain receptors for LH-RH-like peptides.
Maximum Throughput of FHSS Multiple-Access Networks Using MFSK Modulation (2004)

Optimum values for the modulation order M, code rate r, and the number of frequency-hop slots q maximizing the network throughput are obtained based on simulations for frequency-hopped spread-spectrum multiple-access networks, where L Q-ary Reed-Solomon (RS) code symbols are transmitted per hop, and each Q-ary RS code symbol is transmitted using log/sub M/Q M-ary frequency-shift-keying-modulated signals. Network throughput is evaluated under additive white Gaussian noise and Rayleigh fading channels. For the case when the received RS symbol is not interfered by multiple-access interference (MAI), a closed-form expression for the symbol-error probability is derived, and for the case when the symbol is interfered by MAI, simulated symbol-error probabilities are used. It is shown that the optimum M is four or eight, irrespective of the channel environment and the number of users. The optimum code rate is determined primarily based on the channel environment and does not show much dependence on M or Q. It is also shown that for the case of synchronous hopping under Rayleigh fading at high signal-to-noise ratios, the difference in instantaneous power among the interfering users significantly improves the performance, compared with the case when there is no fading. We also consider the case when the receiver erases the symbols that are interfered and compare the performance with the case of the hard decisions receiver.
A robotic device for studying rodent locomotion after spinal cord injury (2005)

We have developed a robotic device (the "rat stepper") for evaluating and training locomotor function of spinal cord injured rodents. This paper provides a detailed description of the device design and a characterization of its robotic performance capabilities.
Pharmacological Inhibition of Endotoxin Responses Is Achieved by Targeting the TLR4 Coreceptor, MD-2 (2005)

The detection of Gram-negative LPS depends upon the proper function of the TLR4-MD-2 receptor complex in immune cells. TLR4 is the signal transduction component of the LPS receptor, whereas MD-2 is the endotoxin-binding unit. MD-2 appears to activate TLR4 when bound to TLR4 and ligated by LPS. Only the monomeric form of MD-2 was found to bind LPS and only monomeric MD-2 interacts with TLR4. Monomeric MD-2 binds TLR4 with an apparent Kd of 12 nM; this binding avidity was unaltered in the presence of endotoxin. E5564, an LPS antagonist, appears to inhibit cellular activation by competitively preventing the binding of LPS to MD-2. Depletion of endogenous soluble MD-2 from human serum, with an immobilized TLR4 fusion protein, abrogated TLR4-mediated LPS responses. By determining the concentration of added-back MD-2 that restored normal LPS responsiveness, the concentration of MD-2 was estimated to be approximately 50 nM. Similarly, purified TLR4-Fc fusion protein, when added to the supernatants of TLR4-expressing cells in culture, inhibited the interaction of MD-2 with TLR4, thus preventing LPS stimulation. The ability to inhibit the effects of LPS as a result of the binding of TLR4-Fc or E5564 to MD-2 highlights MD-2 as the logical target for drug therapies designed to pharmacologically intervene against endotoxin-induced disease.
Histometric Evaluation of Bone Regeneration Around Immediate Implants Partially in Contact With Bone (2000)

Bone regeneration was evaluated around immediate implants partially in contact with bone, with or without the concurrent application of a combination of platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF-1). Mandibular premolars were removed, and the implant osteotomies were prepared; a uniform circumferential gap was prepared 1.25 mm beyond the width of the implant bed in the coronal half. Twelve implants (8.5 x 3.75 mm) were inserted in six dogs. Before insertion, an implant received a single application of 5 micrograms/mL of PDGF and IGF-1 delivered in 0.10 mL of 4% methylcellulose gel or 0.10 mL of 4% methylcellulose gel only as a control. To label regenerated bone, a 2% calcein green solution was administered by intramuscular injection at 0, 7, 15, 30, and 45 days after implant insertion Three and 8 weeks after implant insertion undecalcified sections were obtained, and the degree of bone to implant contact, the bone area, and the intensity of bone labeling were measured into the limits of the eight most coronal threads of the implant (four threads on each side of each implant). The results showed a greater extension of bone-to-implant contact, a larger percentage of bone area, and greater intensity of bone labeling for test versus control implants (P < .01). Within the limits of the present study, it was concluded that the combination of PDGF/IGF-1 might be an alternative for enhancing bone healing around implants partially in contact with bone.
Electronic Conduction in Polyimides (1989)

Commercially available, thermally cyclized, poly(4,4'‐oxydiphenylenepyromellitimide) displays ohmic charge transport when suitably doped through an aqueous interfacial electron transfer reaction. The normally highly insulating polymer increases in conductivity by approximately 11 to 13 orders of magnitude becoming an air‐sensitive semiconductor with bulk conductivities ranging from 10−5 to 10−7 Ω−1 cm−1. The mechanism of conduction appears to be based upon interchain electron hopping.
Inhibitory Effect of an Ergoline Derivative, Methergoline, on Growth Hormone and Prolactin Levels in Acromegalic Patients (1976)

Plasma levels of growth hormone (GH) and prolactin (PRL) were measured in twelve acromegalic patients after acute administration of an ergoline derivative (methergoline) which has been proposed as a specific serotoninergic blocking agent. The administration of methergoline (4 mg p.o.) was followed by a significant decrease in plasma GH and PRL concentrations. The administration to the same subjects of CB 154 (2.5 mg p.o.), a known stimulator of dopaminergic receptors, led to results almost superimposable to those obtained with methergoline although the suppressive effect of CB 154 on GH and PRL levels was more sustained. Also on the ground of results obtained in these patients with the use of cyproheptadine, phentolamine, or pimozide, we have concluded that methergoline inhibition of GH and PRL release is, in acromegalic patients, most probably due to a dopaminergic mechanism of action.
CO-RADS: A Categorical CT Assessment Scheme for Patients Suspected of Having COVID-19—Definition and Evaluation (2020)

Background A categorical CT assessment scheme for suspicion of pulmonary involvement of coronavirus disease 2019 (COVID-19 provides a basis for gathering scientific evidence and improved communication with referring physicians. Purpose To introduce the COVID-19 Reporting and Data System (CO-RADS) for use in the standardized assessment of pulmonary involvement of COVID-19 on unenhanced chest CT images and to report its initial interobserver agreement and performance. Materials and Methods The Dutch Radiological Society developed CO-RADS based on other efforts for standardization, such as the Lung Imaging Reporting and Data System or Breast Imaging Reporting and Data System. CO-RADS assesses the suspicion for pulmonary involvement of COVID-19 on a scale from 1 (very low) to 5 (very high). The system is meant to be used in patients with moderate to severe symptoms of COVID-19. The system was evaluated by using 105 chest CT scans of patients admitted to the hospital with clinical suspicion of COVID-19 and in whom reverse transcription-polymerase chain reaction (RT-PCR) was performed (mean, 62 years ± 16 [standard deviation]; 61 men, 53 with positive RT-PCR results). Eight observers used CO-RADS to assess the scans. Fleiss κ value was calculated, and scores of individual observers were compared with the median of the remaining seven observers. The resulting area under the receiver operating characteristics curve (AUC) was compared with results from RT-PCR and clinical diagnosis of COVID-19. Results There was absolute agreement among observers in 573 (68.2%) of 840 observations. Fleiss κ value was 0.47 (95% confidence interval [CI]: 0.45, 0.47), with the highest κ value for CO-RADS categories 1 (0.58, 95% CI: 0.54, 0.62) and 5 (0.68, 95% CI: 0.65, 0.72). The average AUC was 0.91 (95% CI: 0.85, 0.97) for predicting RT-PCR outcome and 0.95 (95% CI: 0.91, 0.99) for clinical diagnosis. The false-negative rate for CO-RADS 1 was nine of 161 cases (5.6%; 95% CI: 1.0%, 10%), and the false-positive rate for CO-RADS category 5 was one of 286 (0.3%; 95% CI: 0%, 1.0%). Conclusion The coronavirus disease 2019 (COVID-19) Reporting and Data System (CO-RADS) is a categorical assessment scheme for pulmonary involvement of COVID-19 at unenhanced chest CT that performs very well in predicting COVID-19 in patients with moderate to severe symptoms and has substantial interobserver agreement, especially for categories 1 and 5. © RSNA, 2020 <i>Online supplemental material is available for this article.</i>
The Elderly’s Independent Living in Smart Homes: A Characterization of Activities and Sensing Infrastructure Survey to Facilitate Services Development (2015)

Human activity detection within smart homes is one of the basis of unobtrusive wellness monitoring of a rapidly aging population in developed countries. Most works in this area use the concept of "activity" as the building block with which to construct applications such as healthcare monitoring or ambient assisted living. The process of identifying a specific activity encompasses the selection of the appropriate set of sensors, the correct preprocessing of their provided raw data and the learning/reasoning using this information. If the selection of the sensors and the data processing methods are wrongly performed, the whole activity detection process may fail, leading to the consequent failure of the whole application. Related to this, the main contributions of this review are the following: first, we propose a classification of the main activities considered in smart home scenarios which are targeted to older people's independent living, as well as their characterization and formalized context representation; second, we perform a classification of sensors and data processing methods that are suitable for the detection of the aforementioned activities. Our aim is to help researchers and developers in these lower-level technical aspects that are nevertheless fundamental for the success of the complete application.
Emergence of Androgen Independence at Early Stages of Prostate Cancer Progression in <i>Nkx3.1; Pten</i> Mice (2006)

Although androgen deprivation therapy is a widely used treatment for patients with advanced prostate cancer, it ultimately results in the emergence of a hormone-refractory disease that is invariably fatal. To provide insights into the genesis of this disease, we have employed an in vivo model to investigate how and when prostate epithelial cells can acquire the ability to survive and proliferate in the absence of androgens. In particular, we have been studying the evolution of androgen independence in Nkx3.1; Pten mutant mice, which develop prostatic intraepithelial neoplasia and adenocarcinoma as a consequence of aging, as well as androgen-independent phenotypes following castration. We now find that the prostate epithelial cells from these Nkx3.1; Pten mutant mice are capable of surviving and proliferating in the absence of androgens and that they develop androgen-independent phenotypes well before they display overt prostatic intraepithelial neoplasia or cancer phenotypes. Our findings in this mouse model show that acquisition of androgen independence can be uncoupled from overt cancer progression and raise the possibility that hormone-refractory disease can arise at early stages of prostate carcinogenesis.
New technologies in the treatment of diabetes and cardiovascular disease (2016)

Living with diabetes and cardiovascular disease is a reality for millions of people living in South Africa. Lifestyle, stress and the pace at which we conduct our daily lives contributes to many chronic health conditions. Yet we live in an era of new technologies which drives new product innovation and which challenges and empowers our healthcare professionals to be able to make better immediate and patient-centred care decisions.
Double blind controlled trial of effect of cisapride on gastric emptying in diabetics. (2000)

Cisapride improves the symptom score and the solid gastric emptying time in patients suffering from diabetic gastroparesis.
Protein loss during nuclear isolation. (1983)

Cryomicrodissection makes possible the measurement of the entire in vivo protein content of the amphibian oocyte nucleus and provides a heretofore missing baseline for estimating protein loss during nuclear isolation by other methods. When oocyte nuclei are isolated into an aqueous medium, they lose 95% of their protein with a half-time of 250 s. This result implies an even more rapid loss of protein from aqueously isolated nuclei of ordinary-size cells.
Plasma Oxytocin Increases in the Human Sexual Response* (1987)

The purpose of this study was to determine whether plasma oxytocin (OT) levels change during human sexual responses and, if so, to demonstrate the temporal pattern of change. Plasma OT levels were measured by RIA before, during, and after private self-stimulation to orgasm in normal men (n = 9) and women (n = 13). Blood samples were collected continuously through indwelling venous catheters. The subjects pressed a signal to indicate the start and finish of orgasm/ejaculation. Objective assessment of sexual arousal and orgasm was obtained by measuring blood-pulse amplitude and electromyographic activity, recorded continuously throughout testing from an anal device containing a photoplethysmograph and electromyograph electrodes connected to a polygraph located in an adjacent room. These measures allowed collection of data from men and women of changes in blood flow and muscle activity in the lower pelvic/pubic area. Plasma OT levels increased during sexual arousal in both women and men and were significantly higher during orgasm/ejaculation than during prior baseline testing. We suggest that the temporal pattern of secretion could be related to smooth muscle contractions of the reproductive system during orgasm.
The Role of Liver-Derived Insulin-Like Growth Factor-I (2009)

IGF-I is expressed in virtually every tissue of the body, but with much higher expression in the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have demonstrated that liver-derived IGF-I, constituting a major part of circulating IGF-I, is an important endocrine factor involved in a variety of physiological and pathological processes. Detailed studies comparing the impact of liver-derived IGF-I and local bone-derived IGF-I demonstrate that both sources of IGF-I can stimulate longitudinal bone growth. We propose here that liver-derived circulating IGF-I and local bone-derived IGF-I to some extent have overlapping growth-promoting effects and might have the capacity to replace each other (= redundancy) in the maintenance of normal longitudinal bone growth. Importantly, and in contrast to the regulation of longitudinal bone growth, locally derived IGF-I cannot replace (= lack of redundancy) liver-derived IGF-I for the regulation of a large number of other parameters including GH secretion, cortical bone mass, kidney size, prostate size, peripheral vascular resistance, spatial memory, sodium retention, insulin sensitivity, liver size, sexually dimorphic liver functions, and progression of some tumors. It is clear that a major role of liver-derived IGF-I is to regulate GH secretion and that some, but not all, of the phenotypes in the liver-specific IGF-I knockout mice are indirect, mediated via the elevated GH levels. All of the described multiple endocrine effects of liver-derived IGF-I should be considered in the development of possible novel treatment strategies aimed at increasing or reducing endocrine IGF-I activity.
Electrochemical detection of phenolic estrogenic compounds at clay modified carbon paste electrode (2015)

A simple and sensitive electroanalytical method was developed to determine the Endocrine Disrupting chemical 4-tert-octylphenol on clay modified carbon paste electrode (Clay/CPE). The electrochemical response of the proposed electrode was studied by means of cyclic and square wave voltammetry. It has found that the oxidation of 4-tert-octylphenol on the clay/CPE displayed a well-defined oxidation peak. Under these optimal conditions, a linear relation between concentrations of 4-tert-octylphenol current response was obtained over range of 7.26×10−6 to 3.87×10−7 with a detection and quantification limit of 9.2×10−7 M and 3.06×10−6 M, respectively. The correlation coefficient is 0.9963. The modified electrode showed suitable sensitivity, high stability and an accurate detection of 4-tert-octylphenol. The modified electrode also relevant suitable selectivity for various phenolic estrogenic compounds.