gebhart/patrepeval huggingface dataset:
Customer context server application enabling customer-focused e-commerce (2000)

Fragmentation of customer data across internal product based systems is preventing a meaningful customer dialog across channels. This problem is compounded further by the addition of new Internet and customer-facing applications from multiple vendors.
Backscattering in electron beam therapy for energies between 3 and 35 MeV (1982)

Whenever a heterogeneity is present in an electron beam treatment field during radiotherapy, there is the possibility of tissue overdosage at the tissue-heterogeneity interface due to electrons backscattered from the heterogeneity. Measurements of this effect were made in a polystyrene phantom using a purpose-built thin-window parallel-plane ionisation chamber. Materials of various atomic numbers were used as scatterers and the investigations were made over a wide range of electron energies. Electron backscatter factor (EBF), defined as the ratio fo dose at the interface surface with and without the scatterer present, was found to increase with increasing atomic number and decrease with increasing beam energy. Both of these relationships were found to be non-linear. The EBF dependence on the scatterer thickness was also investigated. All data in this work were expressed in relation to the beam energy incident on the scatterer in preference to the nominal beam energy set on the accelerator. This approach enables the dose enhancement at an interface to be predicted from a knowledge of the heterogeneity (atomic number and thickness,), its depth in tissue and the beam energy being used for treatment. The results of this work were compared with the published data and an explanation is offered to account for the difference.
Therapeutic targeting of “undruggable” MYC (2021)

c-MYC controls global gene expression and regulates cell proliferation, cell differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is dysregulated in ≈70% of human cancers and strong evidence implicates aberrantly expressed MYC in both tumor initiation and maintenance. In vivo studies show that MYC inhibition elicits a prominent anti-proliferative effect and sustained tumor regression while any alteration on healthy tissue remains reversible. This opens an exploitable window for treatment that makes MYC one of the most appealing therapeutic targets for cancer drug development. This review describes the main functional and structural features of the protein structure of MYC and provides a general overview of the most relevant or recently identified interactors that modulate MYC oncogenic activity. This review also summarizes the different approaches aiming to abrogate MYC oncogenic function, with a particular focus on the prototype inhibitors designed for the direct and indirect targeting of MYC.
Rola receptorów NMDA w patofizjologii i farmakoterapii wybranych chorób układu nerwowego (2011)

Glutamate is the basic excitatory neurotransmitter acting via N-methyl-D-aspartate receptors (NMDARs). It co-regulates many important physiological functions, including learning, memory, and behaviour. An excess of glutamate, as well as NMDAR over-activity, produce pathological effects. Glutamate-related neurotoxicity is involved in the pathogenesis of many neurological conditions. This article briefly describes the role of the glutamate system in the pathophysiology of brain ischemia, selected neurodegenerative disorders, and schizophrenia. It also reviews the current and potential future status of agents targeting NMDARs in neuropsychopharmacology.
Structures and chromotropic properties of imidazole derivatives produced from 3,6-bis(4,5-diphenyl-2H-imidazol-2-ylidene)cyclohexa-1,4-diene (1983)

Addition of acetic acid to 3,6-bis (4,5-diphenyl-2H-imidazol-2-ylidene) cyclohexa-1,4-diene (1) afforded 2-[4-(4-acetoxy-4,5-diphenyl-4H-imidazol-2-yl) phenyl]-4,5-diphenyl-1H-imidazole (2). Lead dioxide oxidation of (2) in acetic acid yielded 1,4-bis(4-acetoxy-4,5-diphenyl-4H-imidazol-2-yl)-benzene (13) but hexacyanoferrate(III) oxidation in alkaline solution gave a 2,2′-imidazolyl dimer (7) derived via 2-[4-(5-oxo-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]-4,5-diphenyl-1H-imidazole (4).Irradiation of compounds (2) and (13) with u.v. light resulted in the formation of the starting quinonoid compound (1) as indicated by its deep blue colour. However, the dimeric compound (7) shows chromotropism caused by radical dissociation of the dimer during irradiation, heating, or grinding. Particularly rapid reversible photochromic behaviour was observed for (7).
A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors (1999)

We present evidence that the sporulation protein SpoIVFB of Bacillus subtilis is a member of a newly recognized family of metalloproteases that have catalytic centers adjacent to or within the membrane. SpoIVFB is required for converting the membrane-associated precursor protein, pro-sigma(K), to the mature and active transcription factor sigma(K) by proteolytic removal of an N-terminal extension of 20 amino acids. SpoIVFB and other family members share the conserved sequence HEXXH, a hallmark of metalloproteases, as well as a second conserved motif NPDG, which is unique to the family. Both motifs, which are expected to form the catalytic center of the protease, overlap hydrophobic segments that are predicted to be separate transmembrane domains. The only other characterized member of this family of membrane-embedded metalloproteases is the mammalian Site-2 protease (S2P), which is required for the intramembrane cleavage of the eukaryotic transcription factor sterol regulatory element binding protein (SREBP). We report that amino acid substitutions in the two conserved motifs of SpoIVFB impair pro-sigma(K) processing and sigma(K)-directed gene expression during sporulation. These results and those from a similar analysis of S2P support the interpretation that both proteins are founding members of a family of metalloproteases involved in the activation of membrane-associated transcription factors. Thus, the pathways that govern the activation of the prokaryotic transcription factor pro-sigma(K) and the mammalian transcription factor SREBP not only are analogous but also use processing enzymes with strikingly homologous features.
Protection planning in transmission networks (2003)

The protection of transmission networks is discussed. Algorithms and tools which are useful both to support the activity of network planners and to build an automatic network protection system are presented. A definition of general and constrained routing and protection problems in a transmission network is given. Protection planning tools, their functions,and implementation are discussed. An algorithm for multiconstrained routing and protection problems is introduced. The concept of the automatic network protection system is given, and its main features are described. The results of a protection study carried out using the described algorithms are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Heart Rate Prediction Model Based on Physical Activities Using Evolutionary Neural Network (2010)

Physical activity (PA) can influence heart rate(HR). But the relationship between HR and PA is hard to describe. In our previous works, HR prediction models based on PA were designed. However, the prediction time length and accuracy are usually hard to compromise. In this study, a new HR prediction method is proposed. The predicted HR is used as the input in the next prediction step. Only HR at the initial time step and PA signals are needed in a long prediction time length. Evolutionary neural network is used as the mathematic basic of the predictor to ensure the prediction accuracy. The results show the predicted HR can trace the actual HR well.
PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells. (2001)

Inactivating mutations in the PTEN tumor suppressor gene occur in approximately 30-50% of endometrial carcinomas. PTEN is a phosphatase that negatively regulates the phosphoinositide 3-kinase signaling pathway, including the downstream effector AKT. To evaluate the role of PTEN in endometrial growth regulation, we expressed wild-type or mutant PTEN in endometrial carcinoma cell lines. As expected, expression of exogenous PTEN decreased levels of activated AKT in all cell lines examined. However, PTEN induced a G(1) cell cycle arrest specifically in endometrial carcinoma cells that lack endogenous wild-type PTEN. Growth of cells containing wild-type PTEN was unaffected by exogenous PTEN expression. Growth arrest required a functional phosphatase domain but not the PDZ interaction motif of PTEN. Overall levels of CIP/KIP and INK4 family members, the known inhibitory regulators of the G(1) phase of the cell cycle, were unchanged. However, PTEN induced a specific reduction of cyclin D3 levels and an associated increase in the amount of the inhibitor p27(KIP1) complexed with CDK2. Enforced expression of cyclin D3 abrogated the PTEN-induced cell cycle arrest. Although PTEN signaling directly regulates p27(KIP1) levels in some settings, in endometrial carcinoma cells, PTEN expression indirectly regulated p27(KIP1) activity by modulating levels of cyclin D3. These data support multiple mechanisms of PTEN-induced cell cycle arrest.
A Small and Fast Software Implementation of Elliptic Curve Cryptosystems over GF ( p ) on a 16-Bit Microcomputer (1999)

this paper we propose a new typeof prime characteristic of a base field suitablefi small implementation. For arithmetic algorithms of an elliptic curve, in order to realize 4 Kbyte code/data size, which we regard as a reasonably small sizefz most applications on M16C, we mainly adopted standard methods described in [6]. We also show an improved versionof basic arithmeticfti
Reactivity and endogenous modification by nitrite and hydrogen peroxide: does human neuroglobin act only as a scavenger? (2007)

NGB (human neuroglobin), a recently discovered haem protein of the globin family containing a six-co-ordinated haem, is expressed in nervous tissue, but the physiological function of NGB is currently unknown. As well as playing a role in neuronal O2 homoeostasis, NGB is thought to act as a scavenger of reactive species. In the present study, we report on the reactivity of metNGB (ferric-NGB), which accumulates in vivo as a result of the reaction of oxyNGB (oxygenated NGB) with NO, towards NO2- and H2O2. NO2- co-ordination of the haem group accounts for the activity of metNGB in the nitration of phenolic substrates. The two different metNGB forms, with and without the internal disulfide bond between Cys46 (seventh residue on the inter-helix region between helices C and D) and Cys55 (fifth residue on helix D), exhibit different reactivity, the former being more efficient in activating NO2-. The kinetics of the reactions, the NO2--binding studies and the analysis of the nitrated products from different substrates all support the hypothesis that metNGB is able to generate an active species with the chemical properties of peroxynitrite, at pathophysiological concentrations of NO2- and H2O2. Without external substrates, the targets of the reactive species generated by the metNGB/NO2-/H2O2 system are endogenous tyrosine (resulting in the production of 3-nitrotyrosine) and cysteine (oxidized to sulfinic acid and sulfonic acid) residues. These endogenous modifications were characterized by HPLC-MS/MS (tandem MS) analysis of metNGB after reaction with NO2- and H2O2 under various conditions. The internal S-S bond affects the functional properties of the protein. Therefore metNGB acts not only as scavenger of toxic species, but also as a target of the self-generated reactive species. Self-modification of the protein may be related to or inhibit its postulated neuroprotective activity.
All-at-once Optimization for Coupled Matrix and Tensor Factorizations (2011)

Joint analysis of data from multiple sources has the potential to improve our understanding of the underlying structures in complex data sets. For instance, in restaurant recommendation systems, recommendations can be based on rating histories of customers. In addition to rating histories, customers' social networks (e.g., Facebook friendships) and restaurant categories information (e.g., Thai or Italian) can also be used to make better recommendations. The task of fusing data, however, is challenging since data sets can be incomplete and heterogeneous, i.e., data consist of both matrices, e.g., the person by person social network matrix or the restaurant by category matrix, and higher-order tensors, e.g., the "ratings" tensor of the form restaurant by meal by person. In this paper, we are particularly interested in fusing data sets with the goal of capturing their underlying latent structures. We formulate this problem as a coupled matrix and tensor factorization (CMTF) problem where heterogeneous data sets are modeled by fitting outer-product models to higher-order tensors and matrices in a coupled manner. Unlike traditional approaches solving this problem using alternating algorithms, we propose an all-at-once optimization approach called CMTF-OPT (CMTF-OPTimization), which is a gradient-based optimization approach for joint analysis of matrices and higher-order tensors. We also extend the algorithm to handle coupled incomplete data sets. Using numerical experiments, we demonstrate that the proposed all-at-once approach is more accurate than the alternating least squares approach.
Bioengineering Human Myocardium on Native Extracellular Matrix (2015)

Native cardiac extracellular matrix scaffolds maintain matrix components and structure to support the seeding and engraftment of human induced pluripotent stem cell-derived cardiomyocytes and enable the bioengineering of functional human myocardial-like tissue of multiple complexities.
Synthesis of Na-Methoxyindole and Na-Methoxyoxindole Alkaloids Having Yohimbine Skeleton (1992)

The A ~l l y i c n l Chrh Universiry.Yayoi-cho 1-33, Chibo 260, Jml opon Ahba~I -Indoloquinolizidine (1) and yohimbine (7) were converted to the cornspanding Namelhoxyindoles and Na-methoxyoxindoles by the oxidation of the dihydroindole derivatives with Hz02 and sodium tungstale.
The Effectiveness of PCM Wallboards for the Energy Refurbishment of Lightweight Buildings (2014)

Abstract In order to compensate for the small storage capacity of lightweight buildings, that usually suffer from pronounced overheating in summer, the incorporation of Phase Change Materials (PCMs) into the opaque envelope can be an effective way to enhance thermal inertia and to improve the thermal comfort. In particular, PCM wallboards are recommended during refurbishment, as they have a small thickness and can be easily applied on the inner surface of both the walls and the ceiling. In this paper, a comprehensive study is presented about the effectiveness of PCM wallboards for improving summer thermal comfort in existing lightweight buildings. The study is based on dynamic simulations carried out with the software EnergyPlus on a sample office building. The analysis is repeated in four different locations, ranging from Southern Europe (Catania, Italy) to Northern Europe (Paris, France). The results of the simulations may help designers to make the correct choices in terms of position of the PCM wallboards, scheduled rate of nighttime ventilation and value of the peak melting temperature for the specific PCM.
Prevalence of tardive dyskinesia in affective disorder patients. (1983)

Of 83 consecutive patients in an affective disorders clinic who were assessed with the Abnormal Involuntary Movement Scale, 35 (41%) were found to have tardive dyskinesia (TD). TD patients were found to be older than affective disorder patients without TD.
III-V nanowire channel on Si: From high-performance vertical FET to steep-slope devices (2015)

MOSFETs using III-V channels with multi-gate architecture and tunnel junctions are promising alternative building blocks for high-performance and low power nanoelectronic circuits. CMOS. In this paper, we review recent advances in direct integration of vertical III-V nanowire (NW)-channel on Si and FET application such as vertical III-V NW surrounding-gate transistors (SGTs) and tunneling FET (TFETs) using III-V NW/Si heterojunctions.
Differential expression of alpha- and beta-enolase genes during rat heart development and hypertrophy (1995)

We have analyzed the transition between isoforms of the glycolytic enzyme enolase (2-phospho-D-glycerate hydrolyase; EC 4.2.1.11) in rat heart during normal and pathological growth. A striking fall in embryonic alpha-enolase gene expression occurs during cardiac development, mostly controlled at pretranslational steps. In fetal and neonatal hearts, muscle-specific beta-enolase gene expression is a minor contributor to total enolase. Control mechanisms of beta-enolase gene expression must include posttranscriptional steps. Aortic stenosis induces a rapid and drastic decrease in beta-enolase transcript level in cardiomyocytes, followed by the fall in beta-subunit level. In contrast, alpha-enolase transcript level is not significantly altered, although the corresponding subunit level increases in nonmuscle cells. We conclude that, like fetal heart, hypertrophic heart is characterized by a high ratio of alpha- to beta-enolase subunit concentrations. This study indicates that the decrease in beta-enolase gene expression may be linked to beneficial energetic changes in contractile properties occurring during cardiac hypertrophy.
Catalytic Synthesis of Higher Aliphatic Amines from the Corresponding Alcohols (1985)

Abstract Aliphatic amines are of considerable industrial importance and find application in almost every field of modern technology, agriculture, and medicine [1], Lower aliphatic amines (C1 to C6) are important intermediates for the chemical and pharmaceutical industries. A large number of drugs, herbicides, pesticides, dyes, and other chemicals contain amino pups which originate from reactions with such intermediates, Many important applications of higher aliphatic amines (fatty amines) and their derivatives (most important derivatives are quarternary ammonium compounds) are based on their cationic surface activity. Relatively small amounts of such compounds are usually required to achieve the desired changes in surface and colloidal properties. Thus, not surprising, one of the first applications of fatty amines was in the flotation separation of nonmetallic materials such as potash, feldspar, phosphate, and mica. Today, probably the biggest demand for fatty amines lies in the production of fabric softeners. There are other important applications for aliphatic amines in the plastics and protective coat industries as emulsion stabilizers, mold release agents, pigment dispersers, and flushing agents. They are used as catalysts for polyurethane production. For granular products, alkylamines are used as anticaking and antidusting agents. In the rubber industry they are used as oxidation inhibitors and catalysts for accelerating vulcanization. Aliphatic amines find also many applications in the petroleum industry, especially as corrosion inhibitors and as components of lubricating oils, greases, and fuel oil where they act as sludge dispersants and stabilizers. They are added to gasoline as corrosion inhibitors.
Treadmill training of paraplegic patients using a robotic orthosis. (2001)

Recent studies have confirmed that regular treadmill training can improve walking capabilities in incomplete spinal cord-injured subjects. At the beginning of this training the leg movements of the patients have to be assisted by physiotherapists during gait on the moving treadmill. The physical capabilities and the individual experience of the therapists usually limit this training. A driven gait orthosis (DGO) has been developed that can move the legs of a patient in a physiological way on the moving treadmill. The orthosis is adjustable in size so different patients can use it. Actuators at the knee and hip joints are controlled by a position controller. With the DGO the legs of patients with different degrees of paresis and spasticity could be trained for more than half an hour, and physiological gait patterns were obtained.
Automatically Exploiting Implicit Pipeline Parallelism from Multiple Dependent Kernels for GPUs (2016)

Execution of GPGPU workloads consists of different stages including data I/O on the CPU, memory copy between the CPU and GPU, and kernel execution. While GPU can remain idle during I/O and memory copy, prior work has shown that overlapping data movement (I/O and memory copies) with kernel execution can improve performance. However, when there are multiple dependent kernels, the execution of the kernels is serialized and the benefit of overlapping data movement can be limited. In order to improve the performance of workloads that have multiple dependent kernels, we propose to automatically overlap the execution of kernels by exploiting implicit pipeline parallelism. We first propose Coarse-grained Reference Counting-based Scoreboarding (CRCS) to guarantee correctness during overlapped execution of multiple kernels. However, CRCS alone does not necessarily improve overall performance if the thread blocks (or CTAs) are scheduled sequentially. Thus, we propose an alternative CTA scheduler -- Pipeline Parallelism-aware CTA Scheduler (PPCS) that takes available pipeline parallelism into account in CTA scheduling to maximize pipeline parallelism and improve overall performance. Our evaluation results show that the proposed mechanisms can improve performance by up to 67% (33% on average). To the best of our knowledge, this is one of the first work that enables overlapped execution of multiple dependent kernels without any kernel modification or explicitly expressing dependency by the programmer.
Synthesis of phosphotyrosine-containing peptides and their use as substrates for protein tyrosine phosphatases (1993)

Prior methods for the chemical synthesis of phosphotyrosine-containing peptides involved the incorporation of fully protected phosphoamino acids into the peptide chain or phosphorylation of free phenol side chains after peptide assembly is complete. The present work describes a novel and general methodology for the solid-phase synthesis of phosphopeptides, featuring direct incorporation of N alpha-(9-fluorenylmethyloxycarbonyl)-O-phospho-L-tyrosine (unprotected side chain). This technique obviated the formation of peptide byproducts containing tyrosine H-phosphonate, a previously unrecognized side reaction from literature phosphorylation/oxidation approaches. Phosphopeptides corresponding to the tyrosine phosphorylation site of adipocyte lipid binding protein were synthesized by the newer, preferred method. These peptides were purified and characterized by high-performance liquid chromatography (HPLC), capillary zone electrophoresis (CZE), amino acid analysis (AAA), fast atom bombardment mass spectrometry (FABMS), and 31P nuclear magnetic resonance (31P NMR). The synthetic peptides were tested as substrates for two distinct protein tyrosine phosphatases, rat brain protein tyrosine phosphatase (PTPase) and human acid phosphatase. Substrate specificity was measured at pH 6.0 and 37 degrees C, using a colorimetric assay for released inorganic phosphate. Kinetic analysis revealed that both the rat brain PTPase and the human adipocyte acid phosphatase catalyzed peptide dephosphorylation but with different rates and affinities. The rat brain PTPase displayed classical Michaelis-Menten kinetics, with Km's of 68 +/- 9 microM and 42 +/- 11 microM and kcat/Km values of 4.9 x 10(5) s-1 M-1 and 6.9 x 10(5) s-1 M-1 determined for phosphorylated peptides of lengths 4 and 10 residues, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)