gebhart/patrepeval huggingface dataset:
High-level synthesis of dynamic dataflow programs on heterogeneous MPSoC platforms (2016)

The growing complexity of digital signal processing applications make a compelling case the use of high-level design and synthesis methodologies for the implementation on programmable logic devices and embedded processors. Past research has shown that, for complex systems, raising the level of abstraction of design stages does not necessarily come at a penalty in terms of performance or resource requirements. Dataflow programs provide behavioral descriptions capable of expressing both sequential and parallel components of application algorithms and enable natural design abstractions, modularity, and portability. In this paper, an open source tool, implementing dataflow programs onto embedded heterogeneous platforms by means of high-level synthesis, software synthesis and interface synthesis is presented Experimental design results demonstrate the capability and the effectiveness of the tool for implementing a wide range of applications when combined with Vivado HLS.
A Framework for Information-Based Sensor Management for the Detection of Static Targets (2010)

A framework is presented for information-theoretic sensor management for the detection of static targets. The sensor manager searches for targets within a cell grid using a suite of sensor platforms. Each sensor platform may contain one or more sensing modalities, and each of these modalities has known probabilities of detection and false alarm and also has an associated cost of use. Additional information such as motion constraints on the sensors and the prior distribution of the targets in space is incorporated. The sensor manager then directs the movement of the sensors through the grid by maximizing the expected information gain that will be obtained with each new sensor observation. Key modeling questions are addressed, including the selection of an appropriate information measure and the joint or independent management of the sensors. Through a number of simulations, the performance of the sensor manager is compared to the performance of a blind sweep procedure, a random search procedure, and an alternative information-theoretic sensor manager. The intelligent sensor management procedure is demonstrated to achieve a superior performance compared to all of the other three techniques. A specific application area for which the sensor management problem is becoming more critical is landmine detection; thus, the performance of the sensor manager is also analyzed using real data from three different landmine detection sensing modalities, and the proposed sensor management technique is again demonstrated to be superior compared to more simplistic approaches.
Laser in situ keratomileusis in myopic patients with congenital nystagmus (2006)

Selected patients with myopia and congenital nystagmus may benefit from laser refractive surgery. Laser refractive surgery may be safely and accurately performed using the Hansatome microkeratome or the IntraLase femtosecond laser and an active tracking system with or without mechanical fixation. The BSCVA may improve in certain patients postoperatively.
Soldering method using longitudinal ultrasonic (2005)

An efficient ultrasonic soldering method of inserting the metal bumps into the solder is investigated in this work for electronic packaging. The effects of the process parameters such as the ultrasonic frequency, amplitude, dimensions of the metal bump and solder are analyzed through the viscoelastic modeling. The ultrasonic soldering was conducted using the Cu and Au bumps, and the acceptable bonding condition was determined from the tensile strength. Localized heating of the solder was achieved and the stirring action due to the ultrasonic influences the bond strength and microstructure of the eutectic solder. Since higher temperature is obtained with smaller solder, the proposed ultrasonic soldering method appears to be applicable to the high-density electronic packaging.
Activity of temozolomide against human tumor colony-forming units. (1997)

8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one (temozolomide) is a new imidazole tetrazinone compound with promising preclinical and clinical activity in nitrosourea-sensitive and -resistant models and manageable toxicity in Phase I and II clinical trials. In this study, we investigated the antiproliferative activity of temozolomide against a large variety of human tumors taken directly from patients in an in vitro soft agar tumor cloning system. Temozolomide was studied using a continuous exposure at final concentrations from 0.1 to 10.0 microM against a total of 222 tumor specimens, of which 101 (45%) were evaluable. A decrease in tumor colony formation was considered significant if survival of colonies treated with temozolomide was </=50% of that in controls. In vitro responses were seen in 9 of 101 [9%; 95% confidence interval (CI), 3-14], 16 of 100 (16%; 95% CI, 8. 5-23), and 35 of 101 (35%; 95% CI, 26-45) tumor specimens at concentrations of 0.1, 1.0, and 10.0 microM, respectively (P < 0. 001). The level of O6-guanine-alkyl-transferase was evaluable in 19 specimens before treatment but did not correlate with a response to temozolomide. At a concentration of 10 microM, a good cytotoxic activity was seen in breast (42%; 95% CI, 15-72), ovarian (36%; 95% CI, 11-69), and non-small cell lung cancers (27%; 95% CI, 6-61). Interestingly, activity was also seen in renal cell carcinomas (50%; 95% CI, 19-81), colon cancers (42%; 95% CI, 15-72), melanomas (33%; 95% CI, 13-59), and some other tumors, including sarcomas and both prostatic and pancreatic carcinomas that are usually considered very resistant to several conventional chemotherapy agents. Moreover, we observed that a subset of tumors that were not sensitive to dacarbazine, carmustine, cisplatin, doxorubicin, 5-fluorouracil, etoposide, and vinblastine were sensitive to temozolomide. These data indicate both that temozolomide is an active drug in vitro against a large variety of human tumors, including some tumors usually resistant to conventional chemotherapy, and that further clinical evaluation is warranted.
Long-term acyclovir suppression of frequently recurring genital herpes simplex virus infection. A multicenter double-blind trial (1988)

Normal adults with six or more episodes of genital herpes in the previous year were enrolled in a one-year, multicenter, double-blind trial comparing placebo with 400 mg of acyclovir administered orally twice daily. Patients with episodes during the study were offered 200 mg of acyclovir administered orally five times daily for five days; this allowed comparison of suppressive and episodic treatment. After one year, 227 (44%) of 519 patients receiving suppressive treatment and seven (2%) of 431 receiving placebo (episodic) treatment remained free of recurrences, and the mean numbers of recurrences per year were 1.8 and 11.4, respectively. Among 67 patients who had received suppressive therapy for one year, the mean duration of lesions in the first episode following the discontinuation of treatment was 9.3 days compared with 7.3 days among 45 patients who had received episodic therapy for one year. Treatment was well tolerated, and no changes were noted in the in vitro susceptibility to acyclovir of herpes simplex virus cultured during or after the one-year trial. Continuous or episodic oral acyclovir therapy for one year remained safe and effective. (<i>JAMA</i>1988;260:201-206)
Synthesis and characterization of block copolymers containing cationic blocks (1998)

Poly(ethylene glycol)-poly(diallyldimethylammonium chloride) block copolymers containing nearly equal number of both monomer units were synthesized by free radical polymerization using macroazoinitiators of different molecular weights obtained from 2,2'-azoisobutyronitrile (AIBN) and poly(ethylene glycol). Characterization by elemental analysis, gel permeation chromatography and ultracentrifugation proved the formation of ABA-block copolymers. Furthermore, the polymers were characterized by DSC and viscosimetric measurements. The block copolymers lowered the surface tension of their aqueous solutions. Cross-sectional areas Amin of some of the polymers were calculated from surface tension vs. concentration isotherms. The results indicate the PEG-blocks to be adsorbed at the air-water interface, whereas the poly-(DADMAC)-block is completely present in the aqueous phase. The block copolymers are powerful stabilizers in emulsion polymerization of styrene, resulting in monodisperse cationic latexes.
Color recognition by extended color space method for 64-color 2-D barcode (2011)

Colorizing two–dimensional (2-D) barcodes is a promising modality for improvement on design and data capacity. The number of colors employed in recent 2-D color barcodes is limited less than 8. To increase the number of recognizable colors, we propose a color recognition method which classifies 64 colors, using an extended color space and pattern recognition techniques. The proposed method employs 4 seed colors embedded within 64-color code to prevent influences from environment illumination. In the proposed method, we extend the color representation for each code color in 2-D barcode from three components to higher number component. And a classifier is trained using the extended colors captured from several environmental lighting conditions. The classifier is selectable. In this paper, artificial neural network (ANN), support vector machine (SVM) and nearest neighbor (NN) are employed as the classifier. The experimental results shows that the proposed method achieves MSER less than 3.0%. Comparing the number of seed colors, 4 seed color is comparable to that using 8 seed color. SVM achieves the best recognition performance of 1.17% SER. These results suggest that 64-color recognition is possible by the proposed method. 1
Area-Efficient FPGA Implementations of the SHA-3 Finalists (2011)

Secure cryptographic hash functions are core components in many applications like challenge-response authentication systems or digital signature schemes. Many of these applications are used in cost-sensitive markets and thus slow budget implementations of such components are very important. In the present paper, we focus on the new SHA-3 competition, started by the National Institute of Standards and Technology (NIST), which searches for a new hash function in response to security concerns regarding the previous hash functions SHA-1 and the SHA-2 family. This work adds new valuable data to the competition, by providing an evaluation of area-efficient implementations of all finalists. Our results show, that it is possible to implement all candidates reasonably small. We focus on area-efficiency and therefore we do not rank the candidates by absolute throughput, but rather by the area and the throughput-area ratio. The results hint that Grøstl and Keccak are the best overall performers for compact implementations, if the throughput-area ratio is most important. The following candidate is BLAKE, while the Skein and JH implementations trail behind. The area ranking changes the results and puts JH on the top, followed by BLAKE, Grøstl, Keccak and Skein.
Analysis of extractable nuclear antigens by blotting technique. (1988)

By using immunoblotting technique, antigenic structures of various U small nuclear RNPs (UsnRNPs) were analysed which reacted with autoantibodies in sera from patients with collagen diseases. Based on these antigenic structures of UsnRNPs, anti-U1RNP antibodies could be more clearly differentiated from anti-U1U2U4-6RNP [Sm] antibodies. However the reactivity of anti-U1RNP antibodies with each antigenic popypeptides of U1RNP showed marked heterogeneity. An anti- (U1U2) RNP antibody system was newly described with a possible clinical association of the system.Immunoblotting technique was shown to be useful as a sensitive test for screening various anti-ENA antibodies in clinical laboratory. However the sensitivity of the test depended on the concentration of antigens bound to the nitrocellulose membrane.
Ultrasonic examination for resistance spot welds of filter connectors (1994)

One product manufactured by Allied-Signal, Kansas City Division, is a multi-conductor cable called a filter connector that joins two electronic subassemblies. This cable is unusual because it has a signal filter package incorporated into the connector on one end of the cable. The signal filtering is provided by a set of discrete devices, all connected to a common ground plane. This ground plane is spot welded to the outside case of the filter connector which is grounded to the two electronic subassemblies. Routinely, a selected unit is given an environmental stress test consisting of a high amplitude physical shock. Afterwards the unit is tested electrically to make sure it continues to function within tolerance. After one such test, a filter connector failed the electrical test. The test indicated that the ground plane connection provided by the spot welds had broken free and was no longer in contact with the outer shell of the connector. The filter connector was examined by a commercial portable ultrasonic probe detector. No defects were found on the lower ground plane spot welds in any of the filter connectors. They did find six units in which all four of the spot welds were bad, six unitsmore » in which three were bad, ten units in which two were bad, and 46 in which one was bad.« less
Design of a New Tri-Band Microstrip BPF Using Combined Quarter-Wavelength SIRs (2006)

A new tri-band microstrip bandpass filter (BPF) is designed to produce three passbands at the commercially practical frequencies through a single piece of filter circuitry. The basic component used to build the proposed filter consists of two quarter-wavelength ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$lambda/$</tex> 4) stepped-impedance resonators (SIRs). One of the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$lambda/$</tex> 4 SIRs is designed to operate at 1.57 GHz and 5.25 GHz, and the other at 2.45 GHz. The feed positions for the two <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$lambda/$</tex> 4 SIRs are carefully located to have the same distance from the via-hole ground and meanwhile to give the required external quality factors ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$Q_e$</tex> 's). In such a way, the microstripline sections between the via-hole and each of the feed positions can be combined into one to simplify the filter structure, and to reduce the BPF circuit size. Performance of the newly designed tri-band BPF is verified by measured results.
Experimental evaluation of a new braking system for use in passive haptic displays (1999)

Passive haptic displays have several advantages when compared to active devices. Safety elements associated with active haptic displays may make them undesirable for certain applications. One method of actuation for passive haptic robots is through the use of brakes and clutches. Traditionally, friction brakes have undesirable behaviour, such as stiction and delay in response time due to mechanical motion. In this study a new brake concept is proposed. The performance of this brake is evaluated and quantified through a series of controlled experiments. Particular attention is given to the phenomenon of stiction in Delrin, dynamic response of the new brake, and effectiveness of feedback control for braking torque.
Cloning and developmental expression of <i>Sna</i>, a murine homologue of the <i>Drosophila snail</i> gene (1992)

The genetic analysis of dorsoventral patterning in Drosophila has identified a zinc-finger gene, snail, that is required for mesoderm formation. The cloning and nuclease protection analysis of a Xenopus homologue of this gene has suggested a possible role in the mesoderm of vertebrates. Here, we describe the cloning of a murine homologue of snail, Sna, and in situ hybridisation studies of its developmental expression. Sequence analysis reveals substantial conservation of the second to fifth zinc fingers, but not of the first zinc finger in the Sna gene. Expression occurs in the ectoplacental cone, parietal endoderm, embryonic and extraembryonic mesoderm, in neural crest and in condensing precartilage. Based on the timing and spatial restriction of expression in embryonic mesoderm, we suggest that Sna might be required for the early development of this tissue, as is the case for its Drosophila counterpart. In addition, we propose that Sna might have an analogous role in the development of neural crest. The expression in condensing precartilage indicates that this gene also has a later function in chondrogenesis.
First Study of the Safety, Tolerability, and Pharmacokinetics of CP-724,714 in Patients with Advanced Malignant Solid HER2-Expressing Tumors (2007)

Dose-limiting toxicities included hyperbilirubinemia, elevated alanine aminotransferase, thrombocytopenia and pulmonary embolus. Although the protocol-specified maximum tolerated dose of CP-724,714 was 250 mg thrice daily, the recommended phase II dose was 250 mg twice daily due to excessive late-cycle hepatotoxicity. Despite extensive prior treatment, 29% of patients had stable disease. A phase II trial has been initiated in patients with breast cancer.
Conformational and ion binding properties of a cyclic octapeptide, cyclo(Ala‐Leu‐Pro‐Gly)<sub>2</sub> (1992)

The conformation and ion-binding characteristics of a cyclic octapeptide, cyclo (Ala-Leu-Pro-Gly)2, in a liphophilic solvent, acetonitrile, have been studied using CD and nmr spectroscopy. The peptide binds preferentially to divalent cations such as calcium, magnesium, and barium. The conformations of the free cyclic peptide and its calcium complex are very similar with well-defined beta- and gamma-turns. The cyclic peptide readily forms equimolar and possibly 2:1 (peptide:cation) complexes with divalent cations.
Combinatorial Immunotherapy of Polyinosinic–Polycytidylic Acid and Blockade of Programmed Death-Ligand 1 Induce Effective CD8 T-cell Responses against Established Tumors (2014)

Abstract Purpose: Epitope-based cancer vaccines capable of inducing CD8 T-cell responses to tumor-associated antigens (TAA) expressed by tumor cells have been considered as attractive alternatives for the treatment of some types of cancer. However, reliable TAAs have not been identified for most malignant diseases, limiting the development of epitope-based vaccines. Herein, we report that the combinatorial therapy of polyinosinic–polycytidylic acid (poly-IC) and antiprogrammed death-ligand 1 (PD-L1) monoclonal antibody (mAb) can be implemented with good results for tumors where no known TAAs have been identified. Experimental Design: Three cancer mouse models (melanoma, lung, and colon) were used to evaluate therapeutic efficacy and examine the immunologic mechanisms of the poly-IC/anti–PD-L1 mAb therapy. Results: The combined administration of poly-IC and anti–PD-L1 mAb into tumor-bearing mice generated potent immune responses resulting in the complete eradication or remarkable reduction of tumor growth. In some instances, the poly-IC/anti–PD-L1 mAb therapy induced long-lasting protection against tumor rechallenges. The results indicate that CD8 T cells but not CD4 T cells or NK cells mediated the therapeutic efficacy of this combinatorial therapy. Experiments using genetically deficient mice indicate that the therapeutic efficacy of this combinatorial therapy depended in part by the participation of type-I IFN, whereas IFN-γ did not seem to play a major role. Conclusions: The overall results suggest that immunotherapy consisting of the combination of poly-IC/anti–PD-L1 mAb could be a promising new approach for treating patients with cancer, especially those instances where no reliable TAAs are available as a therapeutic vaccine. Clin Cancer Res; 20(5); 1223–34. ©2014 AACR.
Optimizing Treatment of the Partially Platinum-Sensitive Ovarian Cancer Patient (2013)

Ovarian cancer is the leading cause of gynecological cancer deaths worldwide. Despite primary treatment with platinum-containing regimens, the majority of women will experience recurrent disease and subsequent death. Recurrent ovarian cancer remains a challenge for successful management, and the choice of second-line chemotherapy is complex due to the range of different factors that need to be considered. One of the main considerations is the platinum-free interval and, specifically, the optimal treatment for patients who are partially platinum-sensitive (platinum-free interval: 6-12 months). Data from the large, multicenter, randomized OVA-301 study have shown that combined trabectedin-pegylated liposomal doxorubicin (PLD) significantly prolonged median overall survival compared with PLD alone (p = 0.0027) in 214 patients with partially platinum-sensitive advanced relapsed ovarian cancer. Furthermore, in OVA-301 patients with partially platinum-sensitive disease who received platinum therapy immediately after disease progression (n = 94), final median overall survival was improved by 9 months (p = 0.0153) in trabectedin-PLD patients compared with PLD alone. In addition to demonstrating a survival advantage, trabectedin-PLD may also allow the treatment of patients having not yet recovered from previous platinum toxicity. In summary, the data suggest the use of combined trabectedin-PLD as a second-line treatment option in patients with partially platinum-sensitive recurrent ovarian cancer, followed by a third-line platinum-containing regimen.
In Vitro Assays for Detecting Neutralizing and Fusion-Inhibiting Antibodies to SIV <sub>MAC251</sub> (1991)

Sensitive and reproducible assays for SIV infection and syncytium formation have been developed in which high titers of neutralizing and fusion-inhibiting antibodies can be recorded. These assays will contribute toward our understanding of the role of humoral responses in SIV vaccine strategies.
Silver-resistant mutants of Escherichia coli display active efflux of Ag+ and are deficient in porins (1997)

Silver-resistant mutants were selected by stepwise exposure of silver-susceptible clinical strains of Escherichia coli, two of which did not contain any plasmids, to either silver nitrate or silver sulfadiazine. These mutants showed complete cross-resistance to both compounds. They showed low-level cross-resistance to cephalosporins and HgCl2 but not to other heavy metals. The Ag-resistant mutants had decreased outer membrane (OM) permeability to cephalosporins, and all five resistant mutants tested were deficient in major porins, either OmpF or OmpF plus OmpC. However, the well-studied OmpF- and/or OmpC-deficient mutants of laboratory strains K-12 and B/r were not resistant to either silver compound. Resistant strains accumulated up to fourfold less (110m)AgNO3 than the parental strains. The treatment of cells with carbonyl cyanide m-chlorophenylhydrazone increased Ag accumulation in Ag-susceptible and -resistant strains, suggesting that even the wild-type Ag-susceptible strains had an endogenous Ag efflux activity, which occurred at higher levels in Ag-resistant mutants. The addition of glucose as an energy source to starved cells activated the efflux of Ag. The results suggest that active efflux, presumably coded by a chromosomal gene(s), may play a major role in silver resistance, which is likely to be enhanced synergistically by decreases in OM permeability.