gebhart/patrepeval huggingface dataset:
Duty Phase Control for Single-Phase Boost-Type SMR (2008)

In this paper, a novel duty phase control (DPC) for single-phase boost-type switching-mode-rectifier (SMR) is developed and digitally implemented in DSP-based system. Compared to the conventional multiloop control structure with inner current loop and outer voltage loop, it is noted that there is only one voltage loop tuning the phase of predefined duty pattern (i.e. duty phase) in the proposed DPC. Due to no current loop, sampling inductor current and tracking current are unnecessary when SMRs are operated to shape the current waveform and regulate the output voltage. It implies that the single-loop DPC is simple and adaptable to the implementation with digital and analog integrated circuits. In this paper, first, the effect of the duty phase on the input current is analyzed and modeled. It shows that the sinusoidal current waveform can be naturally generated by the predefined duty pattern and the current amplitude is roughly proportional to the controllable duty phase. Then, a voltage controller is designed to regulate the dc output voltage by tuning this duty phase. Finally, some simulated and experimental results have been given to illustrate the performances of the proposed DPC.
The REV-ERBs and RORs: Molecular Links Between Circadian Rhythms and Lipid Homeostasis (2011)

Research efforts spanning the past two decades have established a clear link between nuclear receptor function, regulation of the circadian clock and lipid homeostasis. As such, this family of receptors represents an important area of research. Recent advances in the field have identified two nuclear receptor subfamilies, the REV-ERBs and the 'retinoic acid receptor-related orphan receptors' (RORs), as critical regulators of the circadian clock with significant roles in lipid homeostasis. In this review, the latest information garnered from cutting-edge research on these two nuclear receptor subfamilies will be discussed. Through direct targeting of the REV-ERBs and RORs with synthetic ligands, generation of novel tools aimed at characterizing their function in vivo have been developed, which may lead to novel therapeutics for the treatment of metabolic disorders.
Conclusion (2012)

This book has explored the implications of the philosophy as well as its entailed methodology for science in which modern medicine (or biomedicine) is embedded. The main theses pursued are as follows:
[Adenosine in treatment of rats with spinal cord injury]. (2000)

Adenosine could involve the pathological process of secondary spinal cord injury and might play a protective role in SCI.
THE ARTISTIC FORM OF <i>RASSELAS</i> (1967)

Journal Article THE ARTISTIC FORM OF RASSELAS Get access EMRYS JONES EMRYS JONES Search for other works by this author on: Oxford Academic Google Scholar The Review of English Studies, Volume XVIII, Issue 72, November 1967, Pages 387–401, https://doi.org/10.1093/res/XVIII.72.387 Published: 01 November 1967
Scanning-Based Interaction Techniques for Motor Impaired Users (2013)

Scanning is an interaction method addressing users with severe motor impairments which provides sequential access to the elements of a graphical user interface and enables users to interact with the interface through at least a single binary switch by activating the switch when the desired interaction element receives the scanning focus. This chapter explains the scanning technique and reports on related approaches across three contexts of use: personal computers, mobile devices, and environmental control for smart homes and ambient intelligence environments. In the context of AmI environments, a recent research approach combining head tracking and scanning techniques is discussed as a case study.
Small Interfering RNA in Drug Metabolism and Transport (2007)

RNA interference (RNAi) is a powerful technique that utilizes RNA molecules to specifically knock down the expression of targeted gene at posttranscriptional level. These small interfering RNAs (siRNAs) not only have broad application to basic biomedical research but may be developed as therapeutic agents. Drug-metabolizing enzymes (DMEs) and drug transporters (DTs) are molecular determinants of pharmacokinetic property of a drug. Transcriptional gene expression of DMEs and DTs is controlled by xenobiotic-sensing nuclear receptors (NRs). Because of complexity in studying the function of individual DMEs, DTs and NRs, siRNAs can be an excellent addition to chemical inhibitors and inhibitory antibodies in delineating their specific roles in drug metabolism and transport, gene regulation, and drug-drug interactions. RNAi may be employed to modulate DT expression to overcome multidrug resistance. Recent studies using RNAi to silence gene expression of specific DME, DT and NR, and the impact on drug metabolism and transport are discussed in this review. Concerns remain about the efficiency, specificity, and off-target effects when interpreting data obtained from RNAi studies. Furthermore, potential role for endogenous siRNAs, microRNA (miRNA) molecules, in controlling the posttranscriptional gene regulation of DMEs, DTs and NRs is discussed.
High resolution autofocus for spatial temporal biomedical research (2013)

Maintaining focus has been a critical but challenging issue in optical microscopy, particularly for microscopic imaging systems currently used in biomedical research. During live cell imaging, environmental temperature fluctuations and other factors contribute to the unavoidable focus drift. For single molecular imaging and super resolution, focus drift can be significant even over short durations. The current commercial and experimental solutions are either optically complicated, expensive, or with limited axial resolution. Here, we present a simple autofocus solution based on low cost solid state laser and imaging sensor. By improving the optical train design and using real-time data analysis, improvement in axial resolution by approximately two orders of magnitudes over the focal depth of microscope objectives can be achieved. This solution has been tested for prolonged live cell imaging for fast ramping up in environmental chamber temperature and large daily swing in room temperature. In addition, this system can be used to spatial-temporally measure the surface for three-dimensional cell culture and tissue engineering, with flexibility that exceeds commercially available systems.
Electrodeposition of Copper on Platinum (111) Surfaces Pretreated with Iodine: Studies by LEED, Auger Spectroscopy, and Electrochemistry (1984)

Studies by low energy electron diffraction (LEED) and Auger spectroscopy of copper electrodeposited on well‐characterized platinum (111) surfaces from aqueous sodium perchlorate solutions are reported. Prior to electrodeposition, the platinum (111) surface was pretreated with vapor in ultrahigh vacuum to form a Pt(111) R19.1°‐I superlattice, which protected the platinum surface and the surface of the electrodeposit from attack by the electrolyte and contamination by residual gases. The results were as follows: electrodeposition took place in two narrow, overlapping underpotential deposition linear scan voltammetric peaks followed by one conventional bulk copper deposition peak. Underpotential deposition produced an ordered layer. The first underpotential deposition peak formed a superlattice in which the unit cell contained four iodine atoms and a comparable number of Cu atoms per nine surface Pt atoms . At completion of the underpotential deposition process a coincidence lattice was present in which and . The iodine Auger signal was not appreciably affected by Cu deposition, indicating that the iodine atoms were present in the topmost layer of the surface at all Cu coverages.
Incremental increases in oxytocin infusion regimens for induction of labor at term in primigravidas: A randomized controlled trial (1994)

To compare induction of labor by intravenous oxytocin in regimens increasing incrementally at 15- and 30-minute intervals.In a randomized controlled trial, 124 primigravidas requiring induction of labor by oxytocin infusion were randomly allocated to incremental increases at 30-minute intervals (62 patients) or 15-minute intervals (62 patients). The main outcomes assessed were mode of delivery, complications of labor and delivery (precipitate labor, hyperstimulation, postpartum hemorrhage, perineal tears, puerperal pyrexia), and number of days in the hospital.The 30-minute incremental regimen resulted in less precipitate labor (odds ratio 0.233, 95% confidence interval [CI] 0.042-0.55, chi 2 = 4.133), less uterine hyperstimulation (odds ratio 0.17, 95% CI 0.015-1.906), and reduced length of stay in the hospital (difference in medians 3 days, 95% CI for difference in medians 2-4 days). The induction-delivery interval was longer with 30 minutes (median 8 hours) than with 15 minutes (median 5 hours) (difference in medians 2 hours, 95% CI for difference in medians 0-3 hours). With the 30-minute interval, there was a reduction in the occurrence of postpartum hemorrhage, perineal tears, and puerperal pyrexia, but these differences did not reach statistical significance.For the induction of labor in primigravidas, 30-minute incremental increases in the infusion rate of oxytocin were superior to a 15-minute incremental protocol in reducing the incidence of hyperstimulation and precipitous labor.
Primary Cementing by Reverse Circulation Solves Critical Problem in the North Hassi-Messaoud Field, Algeria (1966)

Abstract After usual cementing techniques failed to give satisfactory results, a systematic analysis of difficulties resulting from high pressures and weak down-hole formations led to the development of a reverse cementing technique. This method has now been used successfully for the past two years on all development wells drilled in the North Hassi- Messaoud field in Algeria. Its application required a modification of the regular differential fill-up equipment and wellhead assembly. The particular drilling and cementing problems encountered in this field are described in detail along with the technique and equipment used to solve them. Introduction A regular drilling schedule for a North Hassi-Messaoud well can be divided into four main steps (Fig. 1):1. A 17 3/8-in. hole is drilled from 0 to 750 ft using a 10 lb/gal bentonite mud improved with CMC (sodium carboxymethyl cellulose). A 13 3/8-in. casing is set and cemented up to the surface.2. A 12 1/4-in. hole is drilled from 750 to 1,800 ft using the same mud. At this depth the mud is converted to a salt-saturated type with a density increasing from 11 to 12 lb/gal. The hole is drilled to 7,500 ft, where an intermediate 95/8-in. casing is set.3. An 8 3/4-in. hole is drilled to 11,000 ft using the same salt-saturated mud weighted with barite up to 18 lb/gal. A 7-in. production casing is set on the top of the pay zone, the Cambrian sandstones.4. The reservoir is cored with 5 15/16-in. diamond core heads using a 12- to 13-lb/gal oil or water base mud. Why Conventional Cementing Techniques Fail Difficulties in Drilling the 8 3/4-in. Hole Three major difficulties are encountered during the drilling of the 8 3/4-in. hole. High-Pressure CaCl2 Formation Water At 8,500 ft in the lower Jurassic, a high pressure, 8,500 psi, CaCl2 -saturated water producing formation is encountered. This formation consists of thin beds of porous and locally vesicular dolomite. The water contains 370 ppm of free HCO3 and 430,000 ppm of CaCl2. Mud contamination by this fluid is spectacular. To prevent this water from coming into the hole during drilling, a mud weight of 17 to 18.5 lb/gal is required. The exact amount depends on variations in permeability and the existence of fine fissures in the formation. However, when making trips, some of this water comes into the hole. It varies from 6 to 90 bbl and badly contaminates large amounts of mud which have to be circulated out and separately reconditioned. Plastic Clays Located between two massive Triassic salt beds, a clay zone about 15-ft thick is encountered at 9,500 ft. These clays are sufficiently plastic so that they continuously extrude into the wellbore. The only remedy is the use of adequate mud weight (17 to 18.5 lb/gal) to balance the formation. Other methods to control these clays (use of shale control type or extreme low filtration water base muds) have failed. JPT P. 146ˆ
The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene. (1988)

Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis. We have identified and sequenced a full-length cDNA for murine ferritin heavy chain. The isolated cDNA is 819 nucleotides in length. It includes 546 nucleotides which encode a protein of 182 amino acids, a 5' noncoding sequence of 120 nucleotides, and a 3'-noncoding region of 153 nucleotides. The sequence displays a high degree of homology to human ferritin H, and includes a portion of the iron-responsive element conserved in chick, frog, and human ferritin. Tumor necrosis factor (TNF), a cytokine which mediates elements of the stress response, induces expression of ferritin H mRNA. Both mouse TA1 adipocytes and human muscle cells increase expression of ferritin H mRNA 4-6-fold after 48 h exposure to TNF. This increase occurs both prior and subsequent to differentiation of adipocytes and muscle cells, and is accompanied by an increase in the synthesis of the ferritin H subunit. These findings suggest a novel role for TNF in iron metabolism.
Van de gastredactie (2024)

Amsterdam University Press is a leading publisher of academic books, journals and textbooks in the Humanities and Social Sciences. Our aim is to make current research available to scholars, students, innovators, and the general public. AUP stands for scholarly excellence, global presence, and engagement with the international academic community.
Design of RF Control System Based on TD-LTE (2013)

This paper explains a method to design a RF system using FPGA and DSP. After DSP sending RF circuit controlling words to FPGA through its EMIF interface, FPGA then imitate the behavior of the EMIF interface to receive these information. The received data will be used to configure the RF circuit correctly. Data information will be sent to FPGA in the same way by DSP when RF circuit is configured completely, Then FPGA sends baseband data to RF circuit which convert it to RF signal. Through simulation, synthesis, plate level verification, and online debugging, this design has realized the correct RF control system, which has been used in the development of RF conformance test instruments.
Proton NMR studies of synthetic peptide analogs of calcium-binding site III of rabbit skeletal troponin C: Effect on the lanthanum affinity of the interchange of aspartic acid and asparagine residues at the metal ion coordinating positions (1988)

The present work determines the contribution of liganding aspartic acid (Asp) residues, at the +X, +Y, and +Z metal ion coordinating positions, to the lanthanum(3+) (La3+) ion binding affinity of synthetic analogues of calcium-binding site III of rabbit skeletal troponin C. Eight 13-residue synthetic analogues were prepared by solid-phase synthesis; the primary sequences of these analogues represent all possible combinations having aspartic acid and asparagine at the +X, +Y, and +Z positions. High-field proton nuclear magnetic resonance (NMR) spectroscopy was used to monitor the binding of the La3+ ion to each of the analogues. Comparison of the chemical shift changes showed large variations in the magnitude of the shift; these were reflected in the La3+ ion association constants determined for each analogue. The association constants ranged from 9.1 x 10(2) M-1 to 2.5 x 10(5) M-1. It was observed that those analogues with the larger number of acidic residues to coordinate the La3+ ion yielded the higher association constants. The La3+ ion binding results demonstrate that the Asp residues at the positions of study contribute equally and in an additive manner to the association constant and that the presence of neighboring Asp residues at either the +X and +Y, the +Y and +Z, or the +X and +Y and +Z metal ion coordinating positions introduced dentate-dentate repulsion, which, acts as to detract from the La3+ ion association constant of the analogues.
Design and Implementation of Communication Based on Multi-Carrier Modulation in Mine (2010)

Geology circumstance of mine seam is extremely complicated and there are many hidden trouble. After analyzed the existing current problems underground mine communication system, a kind of comprehensive information communication system based on the multicarrier modulation technology was designed. This system makes wire communication combined mutually with wireless communication by tandem adapter. In this paper, the framework of communication system network hardware was introduced, and software architecture and the realization of the function were described. Wireless communication system primarily include through-the-earth communication, inductive communication and microwaves communication system, etc.. The key of the system design and the process of implementation were presented. Practical operation shows that the system actually resolved many troubled in coal production site. The technology combines multiple access technology with various modulations technology easily. This system makes use of the advantage of multicarrier technology to provide many kinds of access service in mine. As technical difficulties and major hazard safety issue in communications systems during the operation has been solved, so it has definite meaning and a good value.
Ultrasonic nebulization in a low-emission flame for atomic fluorescence spectrometry (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltrasonic nebulization in a low-emission flame for atomic fluorescence spectrometryM. B. Denton and H. V. MalmstadtCite this: Anal. Chem. 1972, 44, 11, 1813–1818Publication Date (Print):September 1, 1972Publication History Published online1 May 2002Published inissue 1 September 1972https://pubs.acs.org/doi/10.1021/ac60319a003https://doi.org/10.1021/ac60319a003research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expression of <i>Aequorea</i> green fluorescent protein in plant cells (1995)

The coding region of the green fluorescent protein (GFP) from Aequorea victoria has been fused to the cauliflower mosaic virus 35S promoter and introduced into maize leaf protoplasts. Transient expression of GFP was observed. In addition, the coding region of GFP was fused to an Arabidopsis heat shock promoter and co‐transformed with another construct in which GFP has been replaced with chloramphenicol acetyltransferase (CAT). The heat‐induced expression of GFP in maize protoplasts parallels that of CAT. While GFP was expressed in both darkgrown and green maize leaf protoplasts, no green fluorescence was observed in similarly transformed Arabidopsis protoplasts.
CMOS transistor scaling past 32nm and implications on variation (2010)

This paper explores CMOS transistor scaling past the 32 nm generation and its implications on variation. Front-end variation sources are reviewed, with detailed discussion on lithography and polish variation sources past 32 nm. New transistor architectures are discussed, with emphasis on benefits and challenges relative to variation. Detailed variation measurement techniques are reviewed, with supporting multi-generational trend results, including data from the 32 nm node.
Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with <scp>l</scp>- and <scp>d</scp>-Nucleosides (2007)

Biological molecules are predominantly enantioselective. Yet currently two nucleoside analogue prodrugs (3TC and FTC) with opposite chirality compared to physiological nucleosides are clinically approved for the treatment of HIV infections. These prodrugs require conversion to their triphosphorylated forms to achieve pharmacological activity. The first step in the activation of these agents is catalyzed by human deoxycytidine kinase (dCK). This enzyme possesses the ability to phosphorylate nucleosides of the unnatural L-chirality. To understand the molecular basis for the nonenantioselectivity of dCK, we solved the crystal structures of the enzyme in complex with the L-enantiomer and of its physiological substrate deoxycytidine and with the L-nucleoside analogue FTC. These were compared to a structure solved with D-dC. Our results highlight structural adjustments imposed on the L-nucleosides and properties of the enzyme endowing it with the ability to phosphorylate substrates with nonphysiological chirality. This work reveals the molecular basis for the activation of L-nucleosides by dCK.
Proinsulin Targeting to the Regulated Pathway Is Not Impaired in Carboxypeptidase E-deficientCpe /Cpe Mice (1997)

Sorting of proinsulin from the trans-Golgi network to secretory granules is critical for its conversion to insulin as well as for regulated insulin secretion. The proinsulin sorting mechanism is unknown. Recently, carboxypeptidase E (CPE) was proposed as a sorting receptor for prohormones. To know whether CPE is implicated in proinsulin sorting, pancreatic islets were isolated from CPE-deficient Cpefat/Cpefat mice and Cpefat/+ controls, pulse-labeled ([3H]leucine), and then chased in basal medium (90 min) to examine constitutive secretion followed by medium with secretagogues (60 min) to stimulate regulated secretion. Secretion of labeled proinsulin via the constitutive pathway was <2% even in Cpefat/Cpefat islets. After a 150-min chase, only 13% of radioactivity remained as proinsulin in Cpefat/+ islets compared with 46% in Cpefat/Cpefat islets, reflecting slower conversion. Regulated secretion was stimulated to an equal extent from Cpefat/+ and Cpefat/Cpefat mice with 20% of the total content of labeled (pro)insulin released during the 60-min stimulatory period. It is concluded that in CPE-deficient Cpefat/Cpefat mice, proinsulin is efficiently routed to the regulated pathway and its release can be effectively stimulated by secretagogues. CPE is thus not essential for sorting proinsulin to granules.