gebhart/patrepeval huggingface dataset:
The Synthesis of Anatabine and Related Compounds<sup>1</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of Anatabine and Related Compounds1P. M. Quan, T. K. B. Karns, and Louis D. QuinCite this: J. Org. Chem. 1965, 30, 8, 2769–2772Publication Date (Print):August 1, 1965Publication History Published online1 May 2002Published inissue 1 August 1965https://pubs.acs.org/doi/10.1021/jo01019a063https://doi.org/10.1021/jo01019a063research-articleACS PublicationsRequest reuse permissionsArticle Views232Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Risk Factors for Early Occurring Pressure Ulcers Following Spinal Cord Injury (1988)

We carried out a prospective study to determine the association between immobilization in the immediate postinjury period and the development of pressure ulcers in spinal cord-injured patients following their admission to Charity Hospital, New Orleans. Of 39 patients consecutively admitted to the hospital, 23 (59%) developed a grade one ulcer within 30 days, mostly in the sacral region (57%), the peak time of onset being day 4 postinjury (6/23 cases). In partial support of an earlier retrospective study (Linares HA, Mawson AR, Suarez E, Biundo JJ Jr: Association between pressure sores and immobilization in the immediate post-injury period. Orthopedics 1987;10:571-573), duration of unrelieved pressure prior to ward admission was significantly associated with ulcers developing within the first eight days of injury (P = 0.04), but not with ulcers developing during the entire 30-day observation period (P = 0.09). Time on the spinal board was also significantly associated with ulcers developing within 8 days (P = 0.01), but not with ulcers developing within 30 days (P = 0.09). An unexpected finding was the significant inverse association between systolic blood pressure and the development of ulcers both within 8 days (P = 0.03) and within 30 days (P = 0.02), suggesting that reduced tissue perfusion increases the spinal cord-injured patient's susceptibility to pressure ulcers.
Magneto-optic Doppler analyzer: a new instrument to measure mesopause winds (1996)

The magneto-optic Doppler analyzer (MODA) is a new type of passive optical instrument that one can use to measure the Doppler shift of the sodium nightglow emitted at approximately 91 km near the mesopause. From this measurement, horizontal wind signatures are inferred. The MODA is based on a sodium vapor magneto-optic filter that provides inherent wavelength stability at a low cost. The instrument has been used to take nightly zonal and meridional wind measurements since October 1994 at Niwot Ridge, Colorado (40 °N, 105 °W). We obtained an internally consistent wind signal and measured the semidiurnal tide for several seasons.
Lumicolchicine: Lack of antiinflammatory effect (1972)

Abstract The antimitotic effects of colchicine appear to depend upon binding of the drug to the cytoplasmic protein that forms microtubules. Lumicolchicines (photoisomers of colchicine) do not bind to microtubule protein, and do not interfere with the organization of the mitotic spindle. The antiinflammatory effects of colchicine may also depend upon binding to microtubule protein, in appropriate nondividing cells. If so, lumicolchicine would not be expected to have an antiinflammatory effect. Such was the case in this report, in which the reversed passive Arthus reaction in the rat served as test stystem.
A Resolution of the State of Association of Poly(dienyl)lithium Chain Ends in Hydrocarbon Solvents (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Resolution of the State of Association of Poly(dienyl)lithium Chain Ends in Hydrocarbon SolventsLewis J. Fetters and Maurice MortonCite this: Macromolecules 1974, 7, 5, 552–559Publication Date (Print):September 1, 1974Publication History Published online1 May 2002Published inissue 1 September 1974https://doi.org/10.1021/ma60041a004RIGHTS & PERMISSIONSArticle Views128Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (950 KB) Get e-Alerts Get e-Alerts
Changes in villin synthesis and subcellular distribution during intestinal differentiation of HT29-18 clones. (1987)

Brush border in enterocytes is a cell surface specialization intimately associated with terminal differentiation of these cells. HT29-18, a clone derived from the HT-29 human colonic adenocarcinoma cell line, and HT29-18-C1, a subclone from HT29-18 described in the companion paper (Huet, C., C. Sahuquillo-Merino, E. Coudrier, and D. Louvard, 1987, J. Cell Biol., 105:345-357), undergo terminal differentiation with brush borders in the absence of glucose or upon replacement of glucose by galactose in the medium. Taking advantage of this clone and its subclone which can be manipulated in vitro, we have studied the synthesis and subcellular distribution of villin, one major protein in the microvillus core of the brush border. For this study, a monoclonal antibody against villin (BDID2C3) has been isolated and characterized in detail. In addition an ELISA has been set up to measure villin accurately in total cell extracts. Villin content in differentiated HT29-18 cells is close to that seen in normal human colonic cells but 10 times lower in undifferentiated HT29-18 cells. The rate of villin synthesis is dramatically increased in the course of enterocytic differentiation, while villin is remarkably stable after synthesis. We have recently shown, using a cDNA probe for villin, that this change is controlled either at the transcription level or by RNA stabilization (Pringault, E., M. Arpin, A. Garcia, J. Finidori, and D. Louvard, 1986, EMBO (Eur. Mol. Biol. Organ.) J., 5:3119-3124). As shown by immunofluorescence and immunogold labelings, villin is targeted to the brush border area of differentiated HT29-18 cells but remains diffusely distributed in undifferentiated ones.
Arterial Pressure Pulse Contour Analysis Via a Mathematical Model for the Clinical Quantification of Human Vascular Properties (1967)

A lumped parameter physical model of the human vascular system is proposed, which consists of four components- two elastic chambers joined by an inertance and followed by a pure resistance (grossly approximating, respectively, large and small arterial systems joined by long columns of blood and followed by the capillary bed). Equations of this model are presented in both mechanical and electrical equivalents and normal modes of response are derived. These normal modes of the model determine a descriptive equation for the contour of the actual arterial pressure pulse. Particular values of model components can be calculated for specific human subjects under varying conditions of stress or disease through a least squares fit of the descriptive equation to the clinically measured pressure pulse contour.
Ionic‐Liquid Synthesis Route of TiO<sub>2</sub>(B) Nanoparticles for Functionalized Materials (2011)

A fast and soft option! A fast and soft ionic-liquid synthesis route is presented to obtain monophasic TiO2(B) nanoparticles (see figure). The material presents interesting electrochemical properties when used as the negative electrode (charge capacity, reversibility, stability, and low temperature performance) in Li batteries. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Post relational technology-multi-media databases (1990)

Technology for access and storage of unstructured information is discussed. The author looks at various text input methods including OCR and ICR and image processing techniques-image compression standards are outlined. Translation of an image into a WP document is considered. Imaging systems can be classified as: electronic filing cabinet, integrate with other data and integrate into business. The 2 main methods for supporting images inside a database are given. Various specific multi-media databases for handling unstructured text, image and voice data are discussed and developments in this area are identified. >
Right-Handed Helical Foldamers Consisting of De Novo <scp>d</scp>-AApeptides (2017)

New types of foldamer scaffolds are formidably challenging to design and synthesize, yet highly desirable as structural mimics of peptides/proteins with a wide repertoire of functions. In particular, the development of peptidomimetic helical foldamers holds promise for new biomaterials, catalysts, and drug molecules. Unnatural l-sulfono-γ-AApeptides were recently developed and shown to have potential applications in both biomedical and material sciences. However, d-sulfono-γ-AApeptides, the enantiomers of l-sulfono-γ-AApeptides, have never been studied due to the lack of high-resolution three-dimensional structures to guide structure-based design. Herein, we report the first synthesis and X-ray crystal structures of a series of 2:1 l-amino acid/d-sulfono-γ-AApeptide hybrid foldamers, and elucidate their folded conformation at the atomic level. Single-crystal X-ray crystallography indicates that this class of oligomers folds into well-defined right-handed helices with unique helical parameters. The helical structures were consistent with data obtained from solution 2D NMR, CD studies, and molecular dynamics simulations. Our findings are expected to inspire the structure-based design of this type of unique folding biopolymers for biomaterials and biomedical applications.
Analgesic effects of sublingual buprenorphine (1979)

The analgesic effects of sublingually administered buprenorphine 0.4 mg have been compared with morphine 10 mg given intramuscularly in patients following operation. The results indicate a slower onset of action for buprenorphine but of much longer duration than morphine. There were no serious side effects or difference in their incidence between the two drugs.
Expression of the <i>pX</i> Gene of HTLV-I: General Splicing Mechanism in the HTLV Family (1985)

Human T-cell leukemia virus type I (HTLV-I) is an etiological agent of adult T-cell leukemia. A viral gene pX encodes for p40X and it has been proposed that this protein trans-activates the viral long terminal repeat and possibly some cellular genes; this activation may be associated with T-cell transformation. The mechanism of pX gene expression and the primary structure of p40X are now reported. Two-step splicing generates the 2.1-kilobase pX mRNA; the initiator methionine for env becomes part of the pX protein. These splicing signals are conserved among all members of the HTLV family except for the acquired immune deficiency syndrome-associated viruses.
Adenylyl Cyclase Increases Survival in Cardiomyopathy (2002)

Cardiac-directed expression of AC(VI) restores myocyte AC function, improves heart function, increases cAMP generation, abrogates myocardial hypertrophy, and increases survival in Gq cardiomyopathy.
Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells (2007)

To identify cancer-specific targets, we have conducted a synthetic lethal screen using a small interfering RNA (siRNA) library targeting approximately 4,000 individual genes for enhanced killing in the DLD-1 colon carcinoma cell line that expresses an activated copy of the K-Ras oncogene. We found that siRNAs targeting baculoviral inhibitor of apoptosis repeat-containing 5 (survivin) significantly reduced the survival of activated K-Ras-transformed cells compared with its normal isogenic counterpart in which the mutant K-Ras gene had been disrupted (DKS-8). In addition, survivin siRNA induced a transient G(2)-M arrest and marked polyploidy that was associated with increased caspase-3 activation in the activated K-Ras cells. These results indicate that tumors expressing the activated K-Ras oncogene may be particularly sensitive to inhibitors of the survivin protein.
A Prediction Method for Conduction Heating of Reservoirs by Steam Injection (1967)

American Institute of Mining, Metallurgical, and Petroleum Engineers, Inc. This paper was prepared for the 42nd Annual Fall Meeting of the Society of Petroleum Engineers of AIME, to be held in Houston, Tex., Oct. 1–4, 1967. Permission to copy is restricted to an abstract of not more than 300 words. Illustrations may not be copied. The abstract should contain conspicuous acknowledgment of where and by whom the paper is presented. Publication elsewhere after publication in the JOURNAL OF PETROLEUM TECHNOLOGY or the SOCIETY OF PETROLEUM ENGINEERS JOURNAL is usually granted upon request to the Editor of the appropriate journal provided agreement to give proper credit is made. Discussion of this paper is invited. Three copies of any discussion should be sent to the Society of Petroleum Engineers office. Such discussion may be presented at the above meeting and, with the paper, may be considered for publication in one of the two SPE magazines. Abstract A method of reservoir heating involving heat conduction from a thin steam channel within the pay has been investigated. Solutions using a simplified heat flow model are provided to estimate steam injection rate, growth of steam zone and temperature distribution as a result of injecting steam into either a fracture or a thin section of the pay. Equations are also presented to obtain temperature distribution after termination of steam injection. Calculated results show the effects of injection rate, temperature, pay thickness, and well spacing. The conduction heating process can be applicable for raising the entire reservoir to a moderate temperature in a relatively short time. Other advantages over the conventional steam drive are also discussed. It has been shown that a direct steam drive operation which degenerates into steam channeling through a thin section of the pay can be carried on as a conduction heating process. Introduction A direct steam drive process which requires that steam flows through the entire vertical section of the pay suffers from a number of disadvantages. A large quantity of heat is needed to move the steam front through a reservoir, especially with thick pay and high steam temperature. Heat losses into the under and overburden formation also retard the movement of the steam zone. Unless the well spacing is close and/or a very high steam injection rate is used, the project can be too long to be economic. In addition, many heavy oil reservoirs are unsuitable for the direct steam drive process because the oil viscosity is too high. While the oil viscosity in the hot water bank ahead of the steam zone is reduced, the interwell area or the region around the producing wells remains at the original reservoir temperature with no reduction in oil viscosity. Therefore, the oil production rate remains relatively low for a good portion of the project life. A thermal recovery technique called conduction heating may overcome these disadvantages by providing a rapid means of heating a reservoir.
A Window Switching Algorithm for AVS Audio Coding (2007)

In this paper, we present a window switching algorithm employed in AVS (audio video coding standard of China) generic audio coding. The algorithm - energy and unpredictability measure based window switching decision (ENUPM-WSD) - achieves high performance to complexity ratio by taking the advantages of both the low complexity of energy based decision in time domain and the high accuracy of unpredictability based decision in frequency domain. It significantly improves encoded audio quality, especially those with large transient portions, while preserves low average computational complexity in AVS generic audio encoder. Due to the merits, it is accepted as a recommendation module of the AVS audio standard.
Efficient Numerical Solution of the EMI Model Representing the Extracellular Space (E), Cell Membrane (M) and Intracellular Space (I) of a Collection of Cardiac Cells (2021)

The EMI model represents excitable cells in a more accurate manner than traditional homogenized models at the price of increased computational complexity. The increased complexity of solving the EMI model stems from a significant increase in the number of computational nodes and from the form of the linear systems that need to be solved. Here, we will show that the latter problem can be solved by careful use of operator splitting of the spatially coupled equations. By using this method, the linear systems can be broken into sub-problems that are of the classical type of linear, elliptic boundary value problems. Therefore, the vast collection of methods for solving linear, elliptic partial differential equations can be used. We demonstrate that this enables us to solve the systems using shared-memory parallel computers. The computing time scales perfectly with the number of physical cells. For a collection of 512 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mo>×</mml:mo></mml:math> 256 cells, we solved linear systems with about <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>2.5</mml:mn><mml:mo>×</mml:mo><mml:msup><mml:mrow><mml:mn>10</mml:mn></mml:mrow><mml:mn>8</mml:mn></mml:msup></mml:mrow></mml:math> unknows. Since the computational effort scales linearly with the number of physical cells, we believe that larger computers can be used to simulate millions of excitable cells and thus allow careful analysis of physiological systems of great importance.
Culture's Consequences for Management in Hong Kong (1996)

In a recent review of Hofstede's comparative study of business practice and national cultures, 61 works replicating his methods are identified, and the critical four differences in the cultural dimension are ‘largely confirmed’. The only replication of Hofstede's study within IBM (his original sample vehicle) has largely validated the original model some twenty years later. These results seem to confirm the valuable contribution of Hofstede's work, although his model contains the limitations of all models; the simplification of reality into an understandable form cannot do justice to its complexity. In this paper, the main consequences of Hofstede's work for Hong Kong are reviewed. His proposition that culture and particularly social values influence economic activity and management, which is consequently ‘culture-bound’, is restated and supported by more recent studies.
An Above-Elbow Prosthesis Employing Programmed Linkages (1987)

The use of EMG signals from residual muscles to control an above-elbow prosthesis has been tried, but presents many problems, not the least being that the prosthesis is under open-loop control. A more satisfactory control technique is extended physiological proprioception where the inherent proprioceptive feedback present within an intact joint is used to provide closed-loop control. We have developed a prototype of a self-contained above-elbow prosthesis which has electric-powered wrist and elbow joints controlled by an Intel 8751 microcomputer. Our technique is to control the positioning of this above-elbow prosthesis using the motion of the intact shoulder. Grasp, which does not involve positioning in space, is separately controlled using EMG signals from biceps and triceps muscles. The relationship between output (wrist and elbow positions) and input (shoulder position) can be set according to a program or linkage stored in the microcomputer memory. A choice from a range of linkages can enable the user to perform different tasks in different situations. We have verified experimentally that after an amputee has learned to associate the position of the wrist and elbow joints of the prosthesis with his shoulder position, the prosthesis will become a very useful aid. Also, because of the repeatability of operation and the inherent closed-loop nature of the prosthesis, the amputee will be motivated to wear it every day.
Microneedle Array Design Determines the Induction of Protective Memory CD8+ T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice (2011)

This study demonstrates that the design of microneedle patches significantly influences the magnitude and memory of vaccine-induced CD8(+) T cell responses and can be optimised for the induction of desired immune responses. Furthermore, ImmuPatch-mediated delivery may be of benefit to reducing unwanted vaccine reactogenicity. In addition to the advantages of low cost and lack of pain, the development of optimised microneedle array designs for the induction of T cell responses by live vaccines aids the development of solutions to current obstacles of immunization programmes.
Sensation and Perception: An Integrated Approach (1977)

Psychophysics The Orienting System The Auditory System Complex Auditory Phenomena I: Psychoacoustics Complex Auditory Phenomena II: Sound as Information Somesthesis I: Kinesthesis and Cutaneous Sense Somesthesis II: Temperature and Pain The Chemical Sensory System I: Taste The Chemical Sensory System II: Smell The Visual System Fundamental Visual Functions and Phenomena The Perception of Color The Perception of Form and Shape The Perception of Movement The Perception of Space I: Spatial Cues and Constancy The Perception of Space II: Illusions The Development of Perception The Development of Perceptual-Motor Coordination The Perception of Time Sensation, Perception, and Attention: Selected Topics Glossary References Author Index Subject Index.
Safety Profiles and Lesion Size of Different Radiofrequency Ablation Technologies: A Comparison of Large Tip, Open and Closed Irrigation Catheters (2008)

Catheter type, contact conditions, and power settings all play a role in lesion size and in the frequency of complications that occur during an RFA. Cooling the electrode tip, either internally or externally, does not prevent complications from occurring, especially at the higher power control settings. Adding more temperature sensors to the 10 mm seems to reduce the amount of complications that can occur.