gebhart/patrepeval huggingface dataset:
Multifactor User Authentication with In-Air-Handwriting and Hand Geometry (2018)

On wearable and Virtual Reality (VR) platforms, user authentication is a basic function, but usually a keyboard or touchscreen cannot be provided to type a password. Hand gesture and especially in-air-handwriting can be potentially used for user authentication because a gesture input interface is readily available on these platforms. However, determining whether a login request is from the legitimate user based on a piece of hand movement is challenging in both signal processing and matching, which leads to limited performance in existing systems. In this paper, we propose a multifactor user authentication framework using both the motion signal of a piece of in-air-handwriting and the geometry of hand skeleton captured by a depth camera. To demonstrate this framework, we invented a signal matching algorithm, implemented a prototype, and conducted experiments on a dataset of 100 users collected by us. Our system achieves 0.6% Equal Error Rate (EER) without spoofing attack and 3.4% EER with spoofing only data, which is a significant improvement compared to existing systems using the Dynamic Time Warping (DTW) algorithm. In addition, we presented an in-depth analysis of the utilized features to explain the reason for the performance boost.
Pretherapy nuclear factor-κB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma (2006)

Our data are the first to show that pretreatment-activated NF-kappaB significantly correlates with clinical biology of esophageal cancer, and most importantly, with pathCR. To therapeutically exploit NF-kappaB-regulated genes and their pathways, further research is warranted.
New photorefractive effect in graded-gap superlattices (1989)

A photorefractive effect which results from the spatial separation of electrons and holes in compositionally graded semiconductors is demonstrated for the first time. Unlike conventional photorefractive effects, this nonlinear optical phenomenon requires only a single illumination beam, does not rely on the presence of traps, and is intrinsically very fast. The time evolution of the formation and decay of the space-charge electric field is measured via the electro-optic effect using picosecond pump and probe techniques.
Modulation of Autophagy by Sorafenib: Effects on Treatment Response (2016)

The multikinase inhibitor sorafenib is, at present, the only drug approved for the treatment of hepatocellular carcinoma (HCC), one of the most lethal types of cancer worldwide. However, the increase in the number of sorafenib tumor resistant cells reduces efficiency. A better knowledge of the intracellular mechanism of the drug leading to reduced cell survival could help to improve the benefits of sorafenib therapy. Autophagy is a bulk cellular degradation process activated in a broad range of stress situations, which allows cells to degrade misfolded proteins or dysfunctional organelles. This cellular route can induce survival or death, depending on cell status and media signals. Sorafenib, alone or in combination with other drugs is able to induce autophagy, but cell response to the drug depends on the complex integrative crosstalk of different intracellular signals. In cancerous cells, autophagy can be regulated by different cellular pathways (Akt-related mammalian target of rapamycin (mTOR) inhibition, 5' AMP-activated protein kinase (AMPK) induction, dissociation of B-cell lymphoma 2 (Bcl-2) family proteins from Beclin-1), or effects of some miRNAs. Inhibition of mTOR signaling by sorafenib and diminished interaction between Beclin-1 and myeloid cell leukemia 1 (Mcl-1) have been related to induction of autophagy in HCC. Furthermore, changes in some miRNAs, such as miR-30α, are able to modulate autophagy and modify sensitivity in sorafenib-resistant cells. However, although AMPK phosphorylation by sorafenib seems to play a role in the antiproliferative action of the drug, it does not relate with modulation of autophagy. In this review, we present an updated overview of the effects of sorafenib on autophagy and its related activation pathways, analyzing in detail the involvement of autophagy on sorafenib sensitivity and resistance.
Extracting opinions, opinion holders, and topics expressed in online news media text (2006)

This paper presents a method for identifying an opinion with its holder and topic, given a sentence from online news media texts. We introduce an approach of exploiting the semantic structure of a sentence, anchored to an opinion bearing verb or adjective. This method uses semantic role labeling as an intermediate step to label an opinion holder and topic using data from FrameNet. We decompose our task into three phases: identifying an opinion-bearing word, labeling semantic roles related to the word in the sentence, and then finding the holder and the topic of the opinion word among the labeled semantic roles. For a broader coverage, we also employ a clustering technique to predict the most probable frame for a word which is not defined in FrameNet. Our experimental results show that our system performs significantly better than the baseline.
Prosaposin in the secretome of marrow stroma‐derived neural progenitor cells protects neural cells from apoptotic death (2009)

Functionally, adult stem cells not only participate in replication and differentiation to various cell lineages, but also may be involved in rescuing cells from apoptosis. Identifying functional factors secreted by stem cells, as well as their target cells, may advance our understanding of stem cells' multifaceted physiologic functions. Here, we report that mouse bone marrow stromal cell-derived neuroprogenitor cells (mMSC-NPC) provide a protective function by secreting a key factor, prosaposin (PSAP), capable of rescuing mature neurons from apoptotic death. This factor is identified as the lead protein in the secretome of mMSC-NPC cultures by tandem mass spectroscopic profiling, and further validated by western blotting and immunocytochemistry. The secretome of MSC-NPC reduces toxin-induced cell death in cultures of rat pheochromocytoma neuronal cells, human ReNcell CX neurons, and rat cortical primary neurons; removal of PSAP by immunodepletion annuls this protective effect. This neuronal protection against toxin treatment was validated further by the recombinant PSAP peptide. Interestingly, the secretome of neuronal culture does not possess such a self-protective action. We suggest that upon injury, a subgroup of MSCs differentiates into neural/neuronal progenitor cells, and remains in this intermediate stem cell-like stage, defending injured neighboring mature neurons from apoptosis by secreting PSAP.
Overlay techniques for scratchpad memories in low power embedded processors (2006)

Energy consumption is one of the important parameters to be optimized during the design of portable embedded systems. Thus, most of the contemporary portable devices feature low-power processors coupled with on-chip memories (e.g., caches, scratchpads). Scratchpads are better than traditional caches in terms of power, performance, area, and predictability. However, unlike caches they depend upon software allocation techniques for their utilization. In this paper, we present scratchpad overlay techniques which analyze the application and insert instructions to dynamically copy both variables and code segments onto the scratchpad at runtime. We demonstrate that the problem of overlaying scratchpad is an extension of the Global Register Allocation problem. We present optimal and near-optimal approaches for solving the scratchpad overlay problem. The near-optimal scratchpad overlay approach achieves close to the optimal results and is significantly faster than the optimal approach. Our approaches improve upon the previously known static allocation technique for assigning both variables and code segments onto the scratchpad. The evaluation of the approaches for ARM7 processor reports, average energy, and execution time reductions of 26% and 14% over the static approach, respectively. Additional experiments comparing the overlayed scratchpads against unified caches of the same size, report average energy, and execution time savings of 20% and 10%, respectively. We also report data memory energy reductions of 45%-57% due to the insertion of a 1024-bytes scratchpad memory in the memory hierarchy of a digital signal processor (DSP)
Colloidal Silver Proteins Marketed as Health Supplements (1995)

To the Editor. —Silver compounds have been used as medicinals for centuries. 1 In the 19th century, colloidal silver proteins (CSPs) were promoted as cure-alls to prevent and treat diseases such as tetanus and rheumatism. In this century up until World War II, CSPs were widely used to treat colds and gonorrhea. However, in recent decades, the medicinal use of silver has been largely replaced by safer and more effective therapies. Since 1990, interest has resurged in promoting CSP products as essential mineral supplements with multiple health claims (Roma Egli, FDA Nontraditional Drug Compliance Branch, written communication, February 1995). For example, advertising materials in health food stores promote CSP use in more than 650 different diseases. Colloidal silver proteins are being touted as powerful antimicrobials against viruses, bacteria, parasites, and fungi, including human immunodeficiency virus (HIV), herpes, Candida , and tuberculosis. The CSPs also have been advertised as an immune system
Constructing a semantic network for legal content (2005)

The Dutch Tax and Customs Administration (DTCA) is one of many organizations that deal with a multitude of electronic legal data, from various sources and in different formats. In this paper, we describe the results of a study aimed at better access to these sources by having a supplier and format independent knowledge store that describes the sources and their interrelations in a semantic network. Furthermore we developed parsers to automatically detect the identity of sources and typed references within the sources to other legal documents. These parsers can be used to fill and update the semantic network as new documents are added.
A comparison of RNA-Seq and high-density exon array for detecting differential gene expression between closely related species (2010)

RNA-Seq has emerged as a revolutionary technology for transcriptome analysis. In this article, we report a systematic comparison of RNA-Seq and high-density exon array for detecting differential gene expression between closely related species. On a panel of human/chimpanzee/rhesus cerebellum RNA samples previously examined by the high-density human exon junction array (HJAY) and real-time qPCR, we generated 48.68 million RNA-Seq reads. Our results indicate that RNA-Seq has significantly improved gene coverage and increased sensitivity for differentially expressed genes compared with the high-density HJAY array. Meanwhile, we observed a systematic increase in the RNA-Seq error rate for lowly expressed genes. Specifically, between-species DEGs detected by array/qPCR but missed by RNA-Seq were characterized by relatively low expression levels, as indicated by lower RNA-Seq read counts, lower HJAY array expression indices and higher qPCR raw cycle threshold values. Furthermore, this issue was not unique to between-species comparisons of gene expression. In the RNA-Seq analysis of MicroArray Quality Control human reference RNA samples with extensive qPCR data, we also observed an increase in both the false-negative rate and the false-positive rate for lowly expressed genes. These findings have important implications for the design and data interpretation of RNA-Seq studies on gene expression differences between and within species.
El valor de la arquitectura popular en la búsqueda de una modernización de la arquitectura española de posguerra a través de la revista Cortijos y Rascacielos (2012)

Estudio de la importancia de la arquitectura popular en la modernizacion de la arquitectura espanola tras la guerra civil. Decadas de 1940 y 1950.
Conditions for assembly of tubulin-based structures in unfertilized sea urchin eggs Spirals, monasters and cytasters (1992)

Cytasters were induced in the unfertilized eggs of the sea urchin Lytechinus pictus by two different methods: (1) treatment with hexylene glycol or taxol, which are known to lower the tubulin critical concentration in vitro, but do not activate the nuclear cycle, and (2) by raising the cytoplasmic pH from that of unfertilized cytoplasm to that of fertilized, which activated the nuclear cycle and initiated tubulin polymerization. In the unactivated eggs, with increasing concentrations of the inducing agents, temperature and duration of treatment, microtubule structures that formed showed a progression from loose microtubule networks and spiral arrays to tightly organized cytasters. In eggs incubated in sea water containing 2.5 or 10 mM ammonium acetate titrated with HCl or NaOH in steps from pH 5.0 to pH 9.0, the nuclear cycle and tubulin polymerization were initiated at about pH 7.0. The degree of development attainable after three hours was dependent on the pH, with spirals forming at the threshold level of pH 7.0, monasters at pH 7.5, and at pH 8.5 cells formed cytasters, multipolar spindles and even completed multipolar divisions. In unactivated eggs, tubulin was made available by lowering of the tubulin critical concentration; in activated eggs it was made available from some previously unavailable store. The evidence suggests that the amount of assembly-competent tubulin available, regardless of how it is made available, determines the type of structure that is formed, with microtubule bundles and spirals at the lower concentrations and functional cytasters at the upper. We also describe some details of cytaster formation, including the role of microtubule interactions and the movement of dense granules to the aster centers in hexylene glycol-treated eggs.
Experimental Induction of Type 2 Diabetes in Aging-Accelerated Mice Triggered Alzheimer-Like Pathology and Memory Deficits (2014)

Alzheimer's disease (AD) is an age-dependent neurodegenerative disease constituting ~95% of late-onset non-familial/sporadic AD, and only ~5% accounting for early-onset familial AD. Availability of a pertinent model representing sporadic AD is essential for testing candidate therapies. Emerging evidence indicates a causal link between diabetes and AD. People with diabetes are >1.5-fold more likely to develop AD. Senescence-accelerated mouse model (SAMP8) of accelerated aging displays many features occurring early in AD. Given the role played by diabetes in the pre-disposition of AD, and the utility of SAMP8 non-transgenic mouse model of accelerated aging, we examined if high fat diet-induced experimental type 2 diabetes in SAMP8 mice will trigger pathological aging of the brain. Results showed that compared to non-diabetic SAMP8 mice, diabetic SAMP8 mice exhibited increased cerebral amyloid-β, dysregulated tau-phosphorylating glycogen synthase kinase 3β, reduced synaptophysin immunoreactivity, and displayed memory deficits, indicating Alzheimer-like changes. High fat diet-induced type 2 diabetic SAMP8 mice may represent the metabolic model of AD.
AT1 receptor blockade in experimental myocardial ischemia/reperfusion. (1999)

The renin-angiotensin system is activated during myocardial ischemia, and local angiotensin II formation occurs in ischemic hearts. At least two angiotensin II receptor subtypes, the AT1 and the AT2 receptor, have been identified. The cardiovascular effects of angiotensin II have been attributed largely to activation of AT1 receptors. In ventricular preparations from normal rat and pig hearts, the density of AT1 receptors is higher than that of AT2 receptors, whereas data on the AT receptor subtype density and its distribution in human hearts remain controversial. AT1 receptor blockade increases coronary blood flow during ischemia in dogs and during reperfusion in rats, reduces the incidence of ischemia-related arrhythmias in rats and guinea pigs, limits infarct size in pigs, improves functional and metabolic recovery after myocardial ischemia, and attenuates ventricular remodeling post-myocardial infarction in rats. The potential mechanisms responsible for the cardioprotection by AT1 receptor blockade remain to be elucidated in detail, but appear to involve AT2 receptor activation and the subsequent action of bradykinin, prostaglandins, and/or nitric oxide. Patients under treatment with AT1 receptor blockers for indications such as hypertension and ventricular dilation after myocardial infarction are likely to have improved prognosis when suffering an acute myocardial infarction.
The Audion: A new receiver for wireless telegraphy (1906)

The story of the development of a device of a distinctively new order, from its first inception to its practical reality, adds a human interest to its description which is perhaps too often lacking among scientific records. In 1900 when I was beginning experiments on the electrolytic responder, it was my good fortune to have to work upon it at night in my own room, at a table beneath a solitary gas-burner with Welsbach mantel. My source of hertzian waves was the discharge of a small induction-coil placed in an opposite corner and set into operation by a key closed by pulling a string.
Crystallographic Studies of Human MitoNEET (2007)

MitoNEET was identified as an outer mitochondrial membrane protein that can potentially bind the anti-diabetes drug pioglitazone. The crystal structure of the cytoplasmic mitoNEET (residues 33-108) is determined in this study. The structure presents a novel protein fold and contains a [2Fe-2S] cluster-binding domain. The [2Fe-2S] cluster is coordinated to the protein by Cys-72, Cys-74, Cys-83, and His-87 residues. This coordination is also novel compared with the traditional [2Fe-2S] cluster coordinated by four cysteines or two cysteines and two histidines. The cytoplasmic mitoNEET forms homodimers in solution and in crystal. The dimerization is mainly mediated by hydrophobic interactions as well as hydrogen bonds coordinated by two water molecules binding at the interface. His-87 residue, which plays an important role in the coordination of the [2Fe-2S] cluster, is exposed to the solvent on the dimer surface. It is proposed that mitoNEET dimer may interact with other proteins via the surface residues in close proximity to the [2Fe-2S] cluster.
Orthodontic Elastic Embedded in Gingiva for 7 Years (2013)

Dental materials especially orthodontic elastics often get embedded in gingival tissues due to iatrogenic factors. If retained for a long time, inflammatory response starts as asymptomatic crestal bone loss and may progress to severe periodontal abscess. Unsupported orthodontic elastics used for diastema closure may result in exfoliation of teeth, while elastic separators may get embedded in interdental gingiva if banding is performed without removing it. These cases of negligence are detrimental for survival of affected teeth. This paper highlights a case of orthodontic elastic embedded in interproximal gingiva of a 23-year-old healthy female for 7 years after completion of fixed orthodontic treatment. Surprisingly, there was no clinical sign of inflammation around elastic band and it was removed easily without any local anaesthesia. However, mild crestal bone loss was observed on periapical radiograph. The gingiva healed completely after sub gingival debridement.
Fatigue analysis of the surface EMG signal in isometric constant force contractions using the averaged instantaneous frequency (2003)

The averaged instantaneous frequency (AIF) is proposed as an alternative method for the frequency analysis of surface electromyography (EMG) in the study of muscle fatigue during sustained, isometric muscle contractions. Results from performance analysis using experimental EMG signals demonstrate the low variability of the proposed frequency variable. Indeed, the AIF measure is shown to perform significantly better than the widely used mean and median frequency variables, in terms of robustness to the length of the analysis window.
Dinuclear Cobalt Complexes with a Decadentate Ligand Scaffold: Hydrogen Evolution and Oxygen Reduction Catalysis (2015)

A new decadentate dinucleating ligand containing a pyridazine bridging group and pyridylic arms has been synthesized and characterized by analytical and spectroscopic techniques. Four new dinuclear cobalt complexes featuring this ligand have been prepared and thoroughly characterized both in the solid state (X-ray diffraction) and in solution (1D and 2D NMR spectroscopy, ESI-MS, and electrochemical techniques). The flexible but stable coordination environment provided by the ligand scaffold when coordinating Co in different oxidation states is shown to play a crucial role in the performance of the set of complexes when tested as catalysts for the photochemical hydrogen evolution reaction (HER) and chemical oxygen reduction reaction (ORR).
ChemInform Abstract: One‐Pot Phase Transfer Synthesis of Trithiocarbonates from Carbon Disulfide and Alkyl Halides. (1989)

Abstract The trithiocarbonates (III) and (V) are prepared by the method mentioned in the title.