gebhart/patrepeval huggingface dataset:
High-efficiency linear RF Amplifier - a unified circuit approach to achieving compactness and low distortion (2006)

The realization of a highly efficient linearized amplifier has emerged as a paramount issue in the design of advanced mobile handsets. In this paper, a new RF amplifier linearization scheme using a compensating transistor combination is proposed. The devised approach ably utilizes all terminals of an additional transistor that offers a unified pre-post-distortion and cubic distortion characteristic for performance improvement. Meticulous modeling along with a power-dependent Volterra series is performed to identify contributions on each mechanism under various power levels. An experimental four-tone test reveals a maximum 28-dB reduction for the intermodulation distortion at 1.95 GHz, which outperforms typical pre-distortions of 5-10 dB. A single-ended two-stage amplifier module demonstrates a state-of-the-art power efficiency of 55% with 27-dB transducer gain at 24-dBm output power. Meanwhile, the adjacent channel power ratio (ACPR/sub 1/) is maintained with good margins of -35dBc for a four-channel wideband code-division multiple-access signal under all output dynamics. Graceful degradations on modulation bandwidths, tone spacing, bias, and gain variations are also discussed, showing superb performance with virtually no dedicated retuning circuit parameters for multicarrier applications. By combining a bias control along with the proposed linearization technique, the average efficiency (12%) is 3/spl times/ higher than that of the fixed bias (3.94%), demonstrating the potential utility on further prolonging battery lifetime in practical scenarios.
Effect of Sennosides on Colon Motility in Dogs (1988)

Oral administration of sennosides (20-30 mg/kg) to fasted dogs has been shown to induce a strong and long-lasting inhibition of myoelectric colon activity which was evident after a delay of 6-10 h corresponding to oro-cecal transit and colonic metabolism and was accompanied by abundant diarrhea. When sennosides were given 1 h before a meal, the postprandial increase in colon motility failed to appear. Recent studies with strain gage transducers confirm the inhibition of colonic motility after oral sennosides but, in addition, 3-10 'giant contractions' with a high amplitude appeared during the period of inhibition. Most of these single contractions were propagated over the second half of the colon at a velocity of 0.5-2 cm/min. Elimination of liquid feces was always associated with giant contractions. These giant contractions have also been described with other stimuli (i.v. guanethidine or neostigmine, oral castor oil, intraluminal hypertonic glucose) and are therefore not specific for sennosides.
Maternally Transferred Antibodies from DNA-Immunized Avians Protect Offspring against Hepadnavirus Infection (2000)

The outcome and protective efficacy of maternal antibodies elicited by DNA immunization to the large (L) hepadnavirus envelope protein were studied using the duck hepatitis B virus (DHBV) model. Following genetic immunization of breeding ducks with a DHBV L protein gene-bearing plasmid, specific and highly neutralizing antibodies were transferred from the sera of immunized ducks, via the egg yolk, to the progeny of vaccinees. Interestingly, large amounts (60 to 100 mg/egg) of high-titer and L protein-specific yolk immunoglobulins (immunoglobulin Y) accumulated in the egg yolk. These results suggest that eggs from genetically immunized avians may represent a potent source of DNA-designed antibodies specific to viral antigen. Importantly, these antibodies are vertically transmitted and protect offspring against high-titer DHBV challenge.
A GaAs HEMT MMIC chip set for automotive radar systems fabricated by optical stepper lithography (2002)

A production oriented GaAs HEMT MMIC chipset for a 77 GHz FMCW automotive radar system is reported. It differs mainly in two aspects from the GaAs MMIC solutions described earlier: (1) 0.12 /spl mu/m gatelength PHEMTs are fabricated by optical stepper lithography, (2) a coplanar design is used. A fully passivated PHEMT fabrication process is reported with current-gain and power-gain cutoff frequencies exceeding 115 and 220 GHz, respectively. The design and performance of the chipset consisting of four different MMICs (VCO, harmonic mixer, transmitter, receiver) is described. The great potential of this MMIC approach to meet all system requirements of an automotive radar sensor in a cost effective and production oriented way is shown.
Rationale for the Structure of the Model and Protocol for the Internet Printing Protocol (1999)

This document describes IPP from a high level view, defines a roadmap
for the various documents that form the suite of IPP specifications,
and gives background and rationale for the IETF working group's
major decisions. This memo defines an Experimental Protocol for the
Internet community.
Synaptic Vesicle Endocytosis Impaired by Disruption of Dynamin-SH3 Domain Interactions (1997)

The proline-rich COOH-terminal region of dynamin binds various Src homology 3 (SH3) domain-containing proteins, but the physiological role of these interactions is unknown. In living nerve terminals, the function of the interaction with SH3 domains was examined. Amphiphysin contains an SH3 domain and is a major dynamin binding partner at the synapse. Microinjection of amphiphysin's SH3 domain or of a dynamin peptide containing the SH3 binding site inhibited synaptic vesicle endocytosis at the stage of invaginated clathrin-coated pits, which resulted in an activity-dependent distortion of the synaptic architecture and a depression of transmitter release. These findings demonstrate that SH3-mediated interactions are required for dynamin function and support an essential role of clathrin-mediated endocytosis in synaptic vesicle recycling.
New square-root algorithms for Kalman filtering (1995)

Presents some new square-root algorithms that allow more reliable computation of the state estimates, using, as far as possible, quantities obtained via orthogonal operations. New algorithms are given for covariance quantities and information quantities, and a new combined algorithm is also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effect of molecular weight on hydrogen-deuterium exchange in a nonhelical polyamide (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of molecular weight on hydrogen-deuterium exchange in a nonhelical polyamideW. Dale Snyder and Irving M. KlotzCite this: J. Am. Chem. Soc. 1975, 97, 17, 4999–5003Publication Date (Print):August 1, 1975Publication History Published online1 May 2002Published inissue 1 August 1975https://doi.org/10.1021/ja00850a039Request reuse permissionsArticle Views119Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (531 KB) Get e-Alertsclose Get e-Alerts
Diamond as an insulating heat sink for a series combination of IMPATT diodes (1968)

Series connections of IMPATT diodes are capable of giving high microwave power output at a reasonably high impedance level. The series combination avoids many of the stability problems associated with parallel combinations. A series combination of three diodes mounted on a diamond heat sink produced a C3V 13-GHz output of 4.5 watts with an efficiency of 6.4 percent.
The metaphyseal blanch sign of slipped capital femoral epiphysis. (1986)

In the early stage of slipping of the capital femoral epiphysis, the epiphysis slips posteriorly in relation to the neck of the femur. When this occurs, the posterior portion of the femoral head is seen on the anteroposterior radiograph as a crescent-shaped area of increased density overlying the metaphysis adjacent to the epiphyseal plate. This metaphyseal blanch sign suggests that slipping of the capital femoral epiphysis has occurred and that a lateral radiograph should be made to confirm or exclude the diagnosis.
Regulation of expression and activity of the yeast transcription factor ADR1. (1988)

Disruption of ADR1, a positive regulatory gene in the yeast Saccharomyces cerevisiae, abolished derepression of ADH2 but did not affect glucose repression of ADH2 or cell viability. The ADR1 mRNA was 5 kilobases long and had an unusually long leader containing 509 nucleotides. ADR1 mRNA levels were regulated by the carbon source in a strain-dependent fashion. beta-Galactosidase levels measured in strains carrying an ADR1-lacZ gene fusion paralleled ADR1 and ADR1-lacZ mRNA levels, indicating a lack of translational regulation of ADR1 mRNA. ADH2 was regulated by the carbon source to the same extent in all strains examined and showed complete dependence on ADR1 as well. The expression of ADR1 mRNA and an ADR1-beta-galactosidase fusion protein during glucose repression suggested that the activity of the ADR1 protein is regulated at the posttranslational level to properly regulate ADH2 expression. The ADR1-beta-galactosidase fusion protein was able to activate ADH2 expression during glucose repression but showed significantly higher levels of activation upon derepression. A similar result was obtained when ADR1 was present on a multicopy plasmid. These results suggest that low-level expression of ADR1 is required to maintain glucose repression of ADH2 and are consistent with the hypothesis that ADR1 is regulated at the posttranslational level.
Surgical Treatment of Post Phlebitic Syndrome (1982)

Sequelae of deep vein thrombophlebitis, such as post phlebitic syndrome with or without ulceration, can be treated by direct surgery on the valve. Present surgical treatment of stasis ulcer includes removal of the incompetent communicating veins with excision of the ulcer and skin graft. This procedure is usually associated with a high incidence of leg ulcer among the patients with an incompetent deep venous system. Experimental studies to restore venous valve function, such as autogenous vein valve transplant, valvoplasty, homologous vein transplant and synthetic valve procedures, have been tried. It has been shown that the patency rate with autogenous vein graft is higher than with other procedures. The authors have operated on ten patients utilizing autogenous vein valve from the upper extremities to restore a normal functioning venous system of the distal leg. Data on pre- and post-operative, non-invasive, and ascending and descending venography with the results of surgery will be presented and discussed.
Local Search Strategies for Satisfiability Testing (1995)

It has recently been shown that local search is surprisingly good at finding satisfying assignments for certain classes of CNF formulas (Selman et al. 1992). In this paper we demonstrate that the power of local search for satisfiability testing can be further enhanced by employing a new strategy, called &quot;mixed random walk&quot;, for escaping from local minima. We present a detailed comparison of this strategy with simulated annealing, and show that mixed random walk is the superior strategy on several classes of computationally difficult problem instances. We also present results demonstrating the effectiveness of local search with walk for solving circuit synthesis and diagnosis problems. Finally, we show that mixed random walk improves upon the results of Hansen and Jaumard on MAX-SAT problems. 1 Introduction Local search algorithms have been successfully applied to many optimization problems. Hansen and Jaumard (1990) describe experiments using local search for MAX-SAT, i.e., the prob...
Macromol. Biosci. 4/2017 (2017)

Front Cover: A multicomponent polymer is synthesized by CVD copolymerization to enable surface modification of a biointerface or nanoscale interface with multifunctional accessibility in NHS ester-amine conjugation and photo-initiated benzophenone crosslinking reactions. This is reported by Ruei-Hung Yuan, Chih-Yu Wu, Hsing-Ying Tung, Hung-Pin Hsieh, Yi-Jye Li, Yu-Chih Chiang and Hsien-Yeh Chen, article number 1600322.
Molecular transport junctions: vibrational effects (2007)

Introduction (2) Experimental background: Test beds (8) Theoretical approaches: A microscopic model(10) The electron-phonon coupling(14)Time and energy scales(15) Theoretical methods(19)Numerical calculations(28) Incoherent vs. coherent transport (28) Inelastic tunneling spectroscopy: Experimental background(31) Theoretical considerations:the weak coupling limit(36) Theoretical considerations: moderately strong coupling(41)Comparison of approximation schemes(48)Asymmetry in IETS(51)The origin of dips in IETS signals(53)Computational approaches (56) Effects of electron-electron(e-e)interactions (63) Noise (66) Non-linear conductance phenomena (73) Heating and heat conduction: General considerations(77) Heat generation(81) Heat conduction(85) Junction temperature(88) Current induced reactions (91) Summary and outlook (91)
Rationalizing the Role of SAR Tolerance for Ligand-Based Virtual Screening (2011)

It is well appreciated that the results of ligand-based virtual screening (LBVS) are much influenced by methodological details, given the generally strong compound class dependence of LBVS methods. It is less well understood to what extent structure-activity relationship (SAR) characteristics might influence the outcome of LBVS. We have assessed the hypothesis that the success of prospective LBVS depends on the SAR tolerance of screening targets, in addition to methodological aspects. In this context, SAR tolerance is rationalized as the ability of a target protein to specifically interact with series of structurally diverse active compounds. In compound data sets, SAR tolerance articulates itself as SAR continuity, i.e., the presence of structurally diverse compounds having similar potency. In order to analyze the role of SAR tolerance for LBVS, activity landscape representations of compounds active against 16 different target proteins were generated for which successful LBVS applications were reported. In all instances, the activity landscapes of known active compounds contained multiple regions of local SAR continuity. When analyzing the location of newly identified LBVS hits and their SAR environments, we found that these hits almost exclusively mapped to regions of distinct local SAR continuity. Taken together, these findings indicate the presence of a close link between SAR tolerance at the target level, SAR continuity at the ligand level, and the probability of LBVS success.
Development of a Method of Thymocyte Differentiation of Bone Marrow‐Enriched CD34<sup>+</sup>CD38<sup>−</sup>Cells in Postnatal Allogeneic Cultured Thymic Epithelia to Evaluate Immunodeficiency Disorders (1996)

An in vitro model of CD34+CD38- stem cell (SC) differentiation in postnatal cultured thymic epithelia fragment (CTEF) cocultures is described. Sequential phenotypic analysis of the progeny of the SC-CTEF demonstrated predominantly thymocytes and minor populations of promyelocytes, monocytes and natural killer cells. Triple-positive CD3+CD4+CD8+, double-positive CD4+CD8+, and mature single-positive CD4+ and CD8+ T cells, which were TCR alpha beta+, were identified indicating normal thymocyte maturation. In kinetic studies, mature single-positive CD4+ T cells increased from 29% of total cells at one week to 54% at four weeks of coculture. These findings demonstrate that coculture of bone marrow-derived SC and allogeneic cultured thymic epithelia in vitro results in continuous normal predominantly thymocyte differentiation. The SC-CTEF cocultures were then infected with two different strains of human immunodeficiency virus. CD4+ thymocytes were markedly decreased. However, inhibition of early thymocyte maturation steps was also suggested by the presence of increased triple-negative and CD44+CD25-CD3-thymocytes and decreased CD44+CD25+ thymocytes. This model system of thymocyte maturation will be useful in the evaluation of primary T cell immunodeficiency disorders, gene therapy of SC and pharmacological augmentation of thymic function.
Sampling Efficacy for the Red Imported Fire Ant<i>Solenopsis invicta</i>(Hymenoptera: Formicidae) (2011)

Cost-effective detection of invasive ant colonies before establishment in new ranges is imperative for the protection of national borders and reducing their global impact. We examined the sampling efficiency of food-baits and pitfall traps (baited and nonbaited) in detecting isolated red imported fire ant (Solenopsis invicta Buren) nests in multiple environments in Gainesville, FL. Fire ants demonstrated a significantly higher preference for a mixed protein food type (hotdog or ground meat combined with sweet peanut butter) than for the sugar or water baits offered. Foraging distance success was a function of colony size, detection trap used, and surveillance duration. Colony gyne number did not influence detection success. Workers from small nests (0- to 15-cm mound diameter) traveled no >3 m to a food source, whereas large colonies (>30-cm mound diameter) traveled up to 17 m. Baited pitfall traps performed best at detecting incipient ant colonies followed by nonbaited pitfall traps then food baits, whereas food baits performed well when trying to detect large colonies. These results were used to create an interactive model in Microsoft Excel, whereby surveillance managers can alter trap type, density, and duration parameters to estimate the probability of detecting specified or unknown S. invicta colony sizes. This model will support decision makers who need to balance the sampling cost and risk of failure to detect fire ant colonies.
ISOPENTENOL PYROPHOSPHATE ISOMERASE (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTISOPENTENOL PYROPHOSPHATE ISOMERASEB. W. Agranoff, H. Eggerer, U. Henning, and F. LynenCite this: J. Am. Chem. Soc. 1959, 81, 5, 1254–1255Publication Date (Print):March 1, 1959Publication History Published online1 May 2002Published inissue 1 March 1959https://pubs.acs.org/doi/10.1021/ja01514a059https://doi.org/10.1021/ja01514a059research-articleACS PublicationsRequest reuse permissionsArticle Views161Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Keratoprosthesis: Improved Biocompatability Through Design and Surface Modification (1991)

Due to poor biocompatibility, the success of keratoprostheses has been limited. We compared a newly-designed PMMA intracorneal keratoprosthesis, covalently coated with type-I collagen, with an identical, uncoated keratoprosthesis were retained for 15 months, the uncoated implants had more extensive adjacent corneal melting, greater inflammatory response, and more epithelial downgrowth than their collagen-coated counterparts. Electron microscopy showed that stromal collagen fibers had attached to the surface of the coated implants, but not to that of the uncoated ones. Intracorneal keratoprostheses covalently coated with type-I collagen may offer superior biocompatibility and become significantly incorporated into corneal tissues.
[Biological therapy in rheumatoid arthritis]. (2002)

Rheumatoid arthritis is an autoimmune disease of unknown etiology. It represents a public health problem since it affects 2% of economically active population. Treatment with cytotoxic drugs has improved quality of life in these patients. However, a significant amount of patients do not respond or do not tolerate this treatment modality. Biotechnology advances have given rise to a new treatment approach known as biological therapy. This new approach has opened a new therapeutical perspective in these patients. The objective of this publication is to review the different aspects of biological therapy, as well as to inform the initial results of clinical trials in patients with rheumatoid arthritis.
Duodenal Microbiota in Stunted Undernourished Children with Enteropathy (2020)

These results provide support for a causal relationship between growth stunting and components of the small intestinal microbiota and enteropathy and offer a rationale for developing therapies that target these microbial contributions to EED. (Funded by the Bill and Melinda Gates Foundation and others; ClinicalTrials.gov number, NCT02812615.).
Hemodynamic analysis of an adult vein of Galen aneurysm malformation by use of 3D image-based computational fluid dynamics. (2003)

We applied computational fluid dynamic (CFD) analysis on the numerical grid of a 3D rotational digital subtraction angiogram obtained in a 22-year-old male patient, with an accidentally discovered vein of Galen malformation associated with single feeder aneurysm, to understand the flow pattern through the two aneurysms and improve our general understanding of hemodynamic characteristics of this variety of fusiform aneurysm. This technical note provides a good example of the application of CFD to 3D digital subtraction angiography for studying the flow pattern in patients with cerebrovascular disease.
Effects of Antiepileptic Drugs on Mood and Behavior (2006)

Psychiatric disorders in epilepsy have a multifactorial etiology, pharmacotherapy being only one of many risk factors, which can be both biological and psychosocial. Two important mechanisms of drug-induced psychiatric changes are seizure control/forced normalization in psychosis and GABA-ergic effects in depression. Among the psychiatric adverse events of antiepileptic drugs (AEDs), behavioral problems are the most commonly reported, followed by affective disorders. Psychosis is a relatively rare, although severe, complication. Psychotropic effects of AEDs warrant further research because many relevant parameters related to pathological mechanisms, frequency, psychopathology, and prognosis are not well understood. Behavioral side-effect profiles of AEDs, both negative and positive psychotropic effects, should be considered in the choice of the optimal drug for an individual patient.