gebhart/patrepeval huggingface dataset:
Processing, modelling and predicting time-lapse effects of overpressured fluid-injection in a fractured reservoir (2002)

Summary Time-lapse seismology is important for monitoring subsurface pressure changes and fluid movements in producing hydrocarbon reservoirs. We analyse two 4-D, 3C onshore surveys from Vacuum Field, New Mexico, USA, where the reservoir of interest is a fractured dolomite. In Phase VI, a time-lapse survey was acquired before and after a pilot tertiary-recovery programme of overpressured CO2 injection, which altered the fluid composition and the pore-fluid pressure. Phase VII was a similar time-lapse survey in the same location but with a different lower-pressure injection regime. Applying a processing sequence to the Phase VI data preserving normal-incidence shear-wave anisotropy (time-delays and polarization) and maximizing repeatability, interval-time analysis of the reservoir interval shows a significant 10 per cent change in shear-wave velocity anisotropy and 3 per cent decrease in the P-wave interval velocities. A 1-D model incorporating both saturation and pressure changes is matched to the data. The saturation changes have little effect on the seismic velocities. There are two main causes of the time-lapse changes. Any change in pore-fluid pressures modifies crack aspect ratios. Additionally, when there are overpressures, as there are in Phase VI, there is a 90° change in maximum impedance directions, and the leading faster split shear wave, instead of being parallel to the crack face as it is for low pore-fluid pressures, becomes orthogonal to the crack face. The anisotropic poro-elasticity (APE) model of the evolution of microcracked rock, calculates the evolution of cracked rock to changing conditions. APE modelling shows that at high overburden pressures only nearly vertical cracks, to which normal incidence P waves are less sensitive than S waves, remain open as the pore-fluid pressure increases. APE modelling matches the observed time-lapse effects almost exactly demonstrating that shear-wave anisotropy is a highly sensitive diagnostic of pore-fluid pressure changes in fractured reservoirs. In this comparatively limited analysis, APE modelling of fluid-injection at known pressure correctly predicted the changes in seismic response, particularly the shear-wave splitting, induced by the high-pressure CO2 injection. In the Phase VII survey, APE modelling also successfully predicted the response to the lower-pressure injection using the same Phase VI model of the cracked reservoir. The underlying reason for this remarkable predictability of fluid-saturated reservoir rocks is the critical nature and high crack density of the fluid-saturated cracks and microcracks in the reservoir rock, which makes cracked reservoirs critical systems.
The role of water in the synthesis and performance of vapour phase polymerised PEDOT electrochromic devices (2009)

Parameters affecting the quality of vapour phase polymerised (VPP) PEDOT and their influence on electrochromic device performance were investigated. Specifically, the role of water during synthesis was examined and a polymerisation mechanism proposed. Paradoxically, water vapour is essential for PEDOT polymerisation, however, too high a loading leads to crystallite formation in the oxidant layer, rendering the oxidant inactive. Changes in water vapour affect the doping level of the polymer, presumably due to poor conjugation along the polymer's backbone during synthesis. The addition of a surfactant, PPG-ran-PEG, was studied using XPS. The surfactant inhibited oxidant crystal growth and slowed the rate of PEDOT polymerisation, reducing film defects and improving PEDOT conductivity. Controlling and optimising the levels of water vapour and surfactant during synthesis resulted in reproducible, high conductivity, high optical switch, PEDOT films. Finally, complementary dual-polymer electrochromic devices utilising (pre- and post-process-enhanced) VPP PEDOT and PMAS (control) were fabricated and changes in switching transmission evaluated.
Disinfection using ultraviolet radiation as an antimicrobial agent: a review and synthesis of mechanisms and concerns. (2006)

Control of microbes in sensitive health care settings cannot be maintained without effective disinfection methods. Recently, increasing microbial resistance to common chemical agents, including antibiotics, has required the implementation of new approaches to disinfection where such sanitary practices are critical. Pharmaceutical manufacturers and many interrelated industries also have a need for effective disinfection and sanitation strategies. As a result, standard practices that direct and maintain effective microbial controls are established. These practices exploit a thorough understanding of biological processes and manipulate them to preserve the quality and safety of a valuable product. Most biological processes are delicately balanced with their surroundings, or environment. When changes are made to the environment during disinfection, damaged microbes may respond by repairing the immediate damage or by adapting their biological processes through developing a resistance. Unless sound disinfection procedures are consistently applied, new strains of environmental microbes that can utilize multiple resistance markers may be artificially selected. Examples of related drug resistance are currently being studied and managed in many large hospitals, but non-chemical methods are also subject to similar concerns. Here, we review the use of ultraviolet-based disinfection practices, the biological basis for them, and some potential desensitization issues that may develop. Finally, we suggest some approaches to study and practically address these effects.
Infused Autograft Lymphocyte to Monocyte Ratio and Survival in Diffuse Large B Cell Lymphoma (2014)

Infused autograft absolute lymphocyte count is a prognostic factor for survival after autologous peripheral hematopoietic stem cell transplantation (APHSCT) for diffuse large B cell lymphoma (DLBCL). CD14(+) HLA-DR(low/neg) immunosuppressive monocytes affect tumor growth by suppressing host antitumor immunity. Thus, we set out to investigate if the infused autograft lymphocyte to monocyte ratio (A-LMR), as a biomarker of host immunity (ie, lymphocytes) and immunosuppression (ie, monocytes), affects survival after APHSCT. From 1994 to 2012, 379 DLBCL patients who underwent APHSCT were studied. The 379 patients were randomly divided into a training set (n = 253) and a validation set (n = 126). Receiver operating characteristic and area under the curve identified an A-LMR ≥1 as the best cut-off value, which was validated by the k-fold cross-validation in the training set. Multivariate analysis showed A-LMR to be an independent prognostic factor for survival in the training set. Patients with an A-LMR ≥ 1.0 experienced superior overall survival (OS) compared with patients with an A-LMR <1.0 (median OS: 167.2 versus 17.6 months; 5-year OS: 73% [95% confidence interval (CI), 63% to 80%] versus 30% [95% CI, 2% to 38%], P < .0001, respectively) in the training set. In the validation set, an A-LMR ≥ 1 showed a median OS of 181.2 months versus 19.5 months for an A-LMR <1, and 5-year OS rates of 67% (95% CI, 52% to 79%) versus 35% (95% CI, 25% to 47%), P < .0001, respectively. The A-LMR provides a platform to engineer immunocompetent autograft to improve clinical outcomes in DLBCL patients undergoing APHSCT.
A Synthesis of 1<i>H</i>-Indazoles via a Cu(OAc)<sub>2</sub>-Catalyzed N–N Bond Formation (2016)

A facile synthesis of 1H-indazoles featuring a Cu(OAc)2-catalyzed N-N bond formation using oxygen as the terminal oxidant is described. The reaction of readily available 2-aminobenzonitriles with various organometallic reagents led to o-aminoaryl N-H ketimine species. The subsequent Cu(OAc)2-catalyzed N-N bond formation in DMSO under oxygen afforded a wide variety of 1H-indazoles in good to excellent yields.
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. (1996)

In order to assess the relative contributions of farnesylated and/or geranylgeranylated proteins on cell cycle progression from G1 to S phase we designed potent and selective farnesyltransferase (FTI-277) and geranylgeranyltransferase-I (GGTI-298) inhibitors. Flow cytometry studies showed that treatment of NIH3T3 cells with GGTI-298 or lovastatin, which inhibits both protein farnesylation and geranylgeranylation, arrested cells in G0/G1 whereas cells treated with FTI-277 progressed normally through the cell cycle. [3H]thymidine incorporation studies showed that mevalonate and geranylgeraniol, but not farnesol, released the lovastatin G1 block. Furthermore, mevalonate release of the lovastatin G1 block was inhibited by GGTI-298 but not by FTI-277. These results demonstrate that geranylgeranylated proteins are required for cells to proceed from G1 to S phase, and that farnesylated proteins do not play an essential role in the G1 to S phase transition
MAGNETIC AND ELECTRICAL PROPERTIES OF AMORPHOUS Fe_(86)M_4Zr_(10) ALLOYS (1990)

The magnetic and electrical properties of amorphous Fe_(86)M4Zr_(10) (M = V, Cr, Mn, Fe, Co, Ni, Cu, B, Si) alloys are studied. Effects of M on the average magnetic moment and Curie temperature of these alloys are discussed. Electrical resistivity minimum in the vicinity of Tc is attributed to the coherent exchange scattering.
Concentration of tetracycline in human gingival fluid after single doses (1981)

The concentration of tetracycline in gingival fluid was measured following the oral administration of single doses of 250 or 500 mg. Six volunteers received a single dose of either 250 mg or 500 mg of tetracycline and gingival fluid was sampled at 15-min intervals during the first 2 h, 30-min intervals for the following 2 h and at hours 5, 6 and 7. Four volunteers were given a single dose of either 250 mg or 500 mg and were sampled every hour for 24 h. Gingival fluid was sampled using an intracrevicular technique from four gingival sites and blood was obtained by finger puncture. The concentration of tetracycline in gingival fluid peaked at 3 1/2-7 h achieving average levels typically in the range of 5-12 micrograms/ml. Blood levels peaked at 3-4 h and reached values between 1.0 to 2.6 micrograms/ml. Tetracycline was detectable in gingival fluid at least 19 h after a single dose but rarely was detectable at 24 h. The results demonstrated that tetracycline in the gingival fluid was typically 2-10 times blood levels after a single dose.
The Influence of the Probe Connection on mm-Wave Antenna Measurements (2015)

Commonly used connection methods for measuring antennas in the mm-wave range, like connectors or probes, influence the intrinsic behavior of the antenna under test (AUT). It is shown that nearby structures supporting the antenna and probe or connector cause strong interference on the measured antenna pattern. A new connection setup is proposed eliminating the interfering signal. This is confirmed by a detailed simulation model and verified with experimental results. Furthermore, the probe radiates significantly due to the discontinuity from the transitions of the probe tip to the microstrip line. This radiation influences the signal-to-noise ratio, i.e., the dynamic range. Measures are proposed to reduce this interference, resulting in an improved signal-to-noise ratio by approximately 15 dB.
A Fourth-Order Accurate Numerical Boundary Scheme for the Planar Dielectric Interface: a 2-D TM Case (2011)

Preserving high-order accuracy in high-order FDTD solutions across dielectric interfaces is very important for practical time-domain electromagnetic simulations. This paper presents a fourth-order accurate numerical boundary scheme for the planar dielectric interface to be used in the fourth-order FDTD method proposed earlier by the author. The interface scheme for the two-dimensional (2-D) transverse magnetic (TM) polarization case is derived and validated by monitoring the <TEX>$L_2$</TEX> norm errors in the numerical solutions of a partially-filled cavity demonstrating its fourth-order convergence and long-time numerical stability in the presence of the planar dielectric interface.
Dynamic Behaviors of Lipid-Like Self-Assembling Peptide A<SUB>6</SUB>D and A<SUB>6</SUB>K Nanotubes (2007)

Nanoscience and nanotechnology require development of nanomaterials that are amiable for molecular design from bottom up. Molecular designer self-assembling peptides are one of such nanomaterials that will become increasingly important for the endeavor. Peptides have not only been used in all aspects of biomedical and pharmaceutical research and medical products, but also have had enormous impact in nascent field of designed biological materials. We here report the dynamic structures of lipid-like designer peptide A6D (AAAAAAD) and A6K (AAAAAAK) that undergo self-assembly into nanotubes in water and salt solution. We not only analyzed their self-assemblies using dynamic light scattering to determine the critical aggregation concentration (CAC), but also use atomic force microscope to observe their nanostructures. We also propose a simple scheme by which these lipid-like peptides self-assemble into dynamic nanostructures. Since the knowledge of CAC is important for uses of these peptides for a variety of applications, these findings may have significant implications in the study of molecular self-assembly and for a wide range of utilities of designer self-assembling peptide materials.
ATPases as Drug Targets: Insights from Heat Shock Proteins 70 and 90 (2010)

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTATPases as Drug Targets: Insights from Heat Shock Proteins 70 and 90Andrew J. Massey*View Author Information Vernalis (R&D) Ltd., Granta Park, Cambridge, CB21 6GB, U.K.*Contact information: phone, +44 (0)1223 895555; fax, +44 (0)1223 895556; e-mail, [email protected]Cite this: J. Med. Chem. 2010, 53, 20, 7280–7286Publication Date (Web):July 7, 2010Publication History Received16 March 2010Published online7 July 2010Published inissue 28 October 2010https://pubs.acs.org/doi/10.1021/jm100342zhttps://doi.org/10.1021/jm100342zreview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views3902Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cells,Inhibitors,Peptides and proteins,Screening assays,Small molecules Get e-Alerts
Application of Neural Network for Automatic Classification of Leukocytes (2006)

Differential blood count is one of the most frequently used diagnostic methods in medicine. An algorithm for leukocytes classification represents the crucial part of any device for the automatic compilation of a differential blood count. This paper demonstrates a new algorithm for the automatic classification of leukocytes based on neural networks and digital image processing. The results of the algorithm testing show a high sensitivity of the algorithm in leukocyte detection, as well as classification accuracy of 86%.
Exposure of Soil and Groundwater to Spills of Hazardous Materials Transported by Rail: A Geographic Information System Analysis (2006)

The environmental impact of a hazardous material spill is a complex function of the material's physical and chemical characteristics and the local environmental conditions in which it is spilled. This study develops a geographical probability distribution for two important environmental parameters affecting this impact: soil type and groundwater depth. The paper assesses the probability of exposure of various soil types and groundwater depth regions to hazardous material spills from railroad tank car accidents. The State Soil Geographic database (STATSGO), a geographic information system (GIS) database from the U.S. Department of Agriculture, was used to analyze soils, and real-time groundwater data from the U.S. Geological Survey were used to analyze groundwater. The "rail2m" GIS database available from the Bureau of Transportation Statistics was used to conduct overlay analyses with the soil GIS data to obtain the probability of occurrence of various soil types under rail lines. The same method could not be used for groundwater exposure because no suitable GIS database for this parameter was available. Therefore, a nationwide probability distribution of the groundwater depth ranges was developed. The proportion of the three soil types under rail lines was 44.0% for sand, 51.2% for silt, and 4.0% for clay, the remainder being over surface water. The probability of occurrence of five groundwater depth regions was 16.4% for 5 to 15 ft, 12.6% for 15 to 25 ft, 23.3% for 25 to 75 ft, 12.0% for 75 to 125 ft, and 35.9% for greater than 125 ft. A matrix of the probability distribution of environmental scenarios was developed; it is suitable for use in conducting environmental risk assessments of railroad transportation of hazardous materials.
Optical anisotropy of singular and vicinal Si–SiO2 interfaces and H-terminated Si surfaces (1994)

We report the first investigation of the optical anisotropy of H- and SiO2-terminated Si surfaces. We examine six different orientations: (110); several vicinal (111); (113); and vicinal (001). Observed reflectance-difference (RD) spectra fall into two classes according to whether the surface normal is oriented from [111] toward [110] or [001], being consistent with the existence of different step configurations for the two cases. In the (110) class the spectral lineshapes resemble the imaginary part of the Si dielectric function, while in the (001) class they are similar to the energy derivative of the Si reflectance spectrum. To make surface and interface comparison meaningful, we develop an analytic method for correcting interface spectra for the relatively large effects of overlayer thickness. Thickness-corrected RD spectra of Si–SiO2 interfaces are found to differ in small but distinct ways from those of H-terminated surfaces of the same orientation, specifically in the enhancement of spectral features and the appearance of an optical absorption band near 3 eV. Rapid thermal annealing between 900 and 1000 °C increases oxidation-induced interface absorption for the (113) surface and red-shifts the entire spectrum for the (110) surface. We attribute these effects to a relatively high degree of order for (110)-class steps and lower order for (001)-class steps.
Endocytosis by antigen presenting cells: dendritic cells are as endocytically active as other antigen presenting cells. (1992)

Although dendritic cells are the most potent of all antigen presenting cells, they have paradoxically been regarded as having only a minimal capacity for endocytosis, which is a crucial step in antigen processing prior to presentation. Previous studies of dendritic cells, which are only available in small numbers, have been restricted to measurement of long-term endocytosis and so have stressed lysosomal accumulation. Measurement of traffic through late endosomes, which are closely related to the organelle in which antigen processing occurs, has, to date, required large numbers of cells and therefore has not been possible for dendritic cells. To resolve the paradox for dendritic cells, we have developed a flow cytometric assay of fluid-phase endocytosis that assesses late endosomal traffic by kinetic analysis of exocytosis in small numbers of cells. Using this assay, we show that fluid-phase endocytosis--in particular, traffic through late endosomes--is as active in dendritic cells as in other antigen presenting cells.
Enzyme Kinetics (1967)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Enhanced Thermoelectric Properties of Bi<sub>0.5</sub>Sb<sub>1.5</sub>Te<sub>3</sub> Films by Chemical Vapor Transport Process (2011)

Bi₀.₅Sb₁.₅Te₃ films were prepared by a novel chemical vapor transport process through delicate controlling the temperature of the substrate and vapor source. The power factor reaches 30 μW cm⁻¹ K⁻¹ at room temperature, which is much higher than the value of the Bi₀.₅Sb₁.₅Te₃ films prepared by other techniques. The enhancement of thermoelectric properties might be attributed to the higher carrier mobility (252 cm² V⁻¹ s⁻¹), coming from the effective interparticle contiguity of (00L) oriented nanoplates embedded in the present Bi₀.₅Sb₁.₅Te₃ films.
Transgenic Tobacco Plants Expressing Pea Chloroplast Nmdh cDNA in Sense and Antisense Orientation (Effects on NADP-Malate Dehydrogenase Level, Stability of Transformants, and Plant Growth) (1997)

A full-length cDNA encoding light-activated chloroplast NADP-malate dehydrogenase (NADP-MDH) (EC 1.1.1.82) from pea (Pisum sativum L.) was introduced in the sense and antisense orientation into tobacco (Nicotiana tabacum L.). Transgenic plants with decreased or increased expression levels were obtained. Because of substantial age-dependent differences in individual leaves of a single plant, standardization of NADP-MDH levels was required first. Then, extent and stability of over- or under-expression of Nmdh, the gene encoding NADP-MDH, was characterized in the various transformants. Frequently, cosuppression effects were observed, indicating sufficient homology between the endogenous tobacco and the heterologous pea gene. Analysis of the T1 and T2 progeny of a series of independent transgenic lines revealed that NADP-MDH capacity ranged between 10% and [greater than or equal to]10-fold compared with the wild type. Under ambient conditions whole-plant development, growth period, and fertility were unaffected by NADP-MDH reduction to 20% of the wild-type level; below this threshold plant growth was retarded. A positive growth effect was registered in young plants with stably enhanced NADP-MDH levels within a defined developmental window.