gebhart/patrepeval huggingface dataset:
Dry skin in the winter is related to the ceramide profile in the stratum corneum and can be improved by treatment with a <i><scp>E</scp>ucalyptus</i> extract (2013)

These results suggest that not only the level of CER, but also specific CER species strongly contribute to dry skin relief and products that increase those are useful to improve dry skin conditions.
Foldamer scaffolds suggest distinct structures are associated with alternative gains-of-function in a preamyloid toxin (2016)

An oligoquinoline foldamer library was synthesized and screened for antagonism of lipid bilayer catalysed assembly of islet amyloid polypeptide (IAPP). One tetraquinoline, ADM-116, showed exceptional potency not only in this assay, but also in secondary assays measuring lipid bilayer integrity and rescue of insulin secreting cells from the toxic effects of IAPP. Structure activity studies identified three additional oligoquinolines, closely related to ADM-116, which also have strong activity in the primary, but not the secondary assays. This contrasts work using an oligopyrdyl foldamer scaffold in which all three assays are observed to be correlated. The results suggest that while there is commonality to the structures and pathways of IAPP conformational change, it is nevertheless possible to leverage foldamers to separately affect IAPP's alternative gains-of-function.
Studies on the productive technology of flavonoids extract from the leaves of Phyllostachys pubescens (2004)

OBJECTIVE To study the productive technology of flavonoids extract from the leaves of Phyllostachys pubescens. METHOD The leaves of Phyllostachys pubescens was extracted with boiling water. The filtrate were adsorbed on macroporous resin column and eluted by 70%ethanol. The alcoholic eluate after concentration was dissolved with ethanol or acetone. Filter the solution to remove insoluble sediments, decompress and concentrate the solution to extract. Then dry in vacuum to obtain yellow powder. RESULTS The total flavonoids contents was over 40%. CONCLUSION Technical conditions for the preparation of Phyllostachys pubescens flavonoids extract are optimized, simple, and such extraction is suitable for mass production.
Fractional delay digital filters (2002)

Fractional delay digital filters (FDDFs) can be used for implementing discrete-time systems which include noninteger delays, i.e., delays that are not multiples of the sampling period. The use of finite impulse response (FIR)-type FDDFs for implementing junctions of digital waveguides is discussed. As examples of useful applications, the fractional delay extension of the Kelly-Lochbaum tube model and a side branch placed at an arbitrary point of a digital waveguide are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Vision systems for PCB manufacturing in Japan (2002)

Current vision systems in Japanese printed circuit board (PCB) manufacturing lines are described. Vision systems have been introduced into almost every level of PCB manufacturing in Japan. They include mask pattern inspection machines, PCB pattern inspection machines, surface-mount device (SMD) mounters with visual positioning, mounted SMD visual inspection machines, soldering inspection machines, and assembled PCB visual inspection machines. Most of these vision systems were integrated successfully and achieved significant benefits. Rapid development of SMDs necessitated the development of new types of mounters and visual inspection systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Aminoesters of 1-Substituted Alicyclic Carboxylic Acids (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAminoesters of 1-Substituted Alicyclic Carboxylic AcidsCharles H. Tilford, Lewis A. Doerle, M. G. Van. Campen, and Robert S. SheltonCite this: J. Am. Chem. Soc. 1949, 71, 5, 1705–1709Publication Date (Print):May 1, 1949Publication History Published online1 May 2002Published inissue 1 May 1949https://pubs.acs.org/doi/10.1021/ja01173a044https://doi.org/10.1021/ja01173a044research-articleACS PublicationsRequest reuse permissionsArticle Views219Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Methotrexate and gemcitabine combination chemotherapy for the treatment of malignant pleural mesothelioma (2013)

Malignant pleural mesothelioma (MPM) is an aggressive tumor of serosal surfaces with a poor prognosis. Methotrexate and gemcitabine have exhibited single-agent activity in MPM. We evaluated the feasibility of sequential administration of these agents in the treatment of MPM. A total of 21 patients with MPM received a 30-min infusion of 100 mg/m<sup>2</sup> methotrexate and, 30 min later, a 30-min infusion of 800 mg/m<sup>2</sup> gemcitabine. Twenty-four hours following the administration of methotrexate, leucovorin rescue therapy was initiated (10 mg/m<sup>2</sup> leucovorin administered 4 times at 6-h intervals). These treatments were administered weekly, with 4 weekly administrations constituting a cycle of therapy. A total of 88 cycles were administered to the 21 patients, with each patient receiving 1-10 cycles (median, 4.2 cycles). Eight patients (38.1%) exhibited a partial response, 10 patients (47.6%) had stable disease and 3 patients (14.3%) had progressive disease. The median overall survival was 19.4 months (range, 02-41 months). One-year and 2-year survival rates were 61.9 and 38.1%, respectively. Hematological toxicity was considered acceptable, with grade 3-4 toxicities occurring in 3 (14.3%) patients. Non-hematologic toxicity was generally mild. There was no treatment-related mortality. Our results suggest that methotrexate and gemcitabine combination therapy is feasible and effective in the treatment of MPM. This regimen may offer an alternative to platinum-based chemotherapy and a prospective trial including a larger cohort of patients is recommended to confirm these results.
Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats (2003)

In Parkinson's disease, nigral dopaminergic neurones degenerate, whereas post-synaptic striatal target neurones are spared. In some atypical parkinsonian syndromes, both nigral and striatal neurones degenerate. Reduced activity of complex I of the mitochondrial respiratory chain has been implicated in both conditions, but it remains unclear if this affects the whole organism or only the degenerating brain structures. We therefore investigated the differential vulnerability of various brain structures to generalized complex I inhibition. Male Lewis rats infused with rotenone, a lipophilic complex I inhibitor [2.5 mg/kg/day intraveneously (i.v.) for 28 days], were compared with vehicle-infused controls. They showed reduced locomotor activity and loss of striatal dopaminergic fibres (54%), nigral dopaminergic neurones (28.5%), striatal serotoninergic fibres (34%), striatal DARPP-32-positive projection neurones (26.5%), striatal cholinergic interneurones (22.1%), cholinergic neurones in the pedunculopontine tegmental nucleus (23.7%) and noradrenergic neurones in the locus ceruleus (26.4%). Silver impregnation revealed pronounced degeneration in basal ganglia and brain stem nuclei, whereas the hippocampus, cerebellum and cerebral cortex were less affected. These data suggest that a generalized mitochondrial failure may be implicated in atypical parkinsonian syndromes but do not support the hypothesis that a generalized complex I inhibition results in the rather selective nigral lesion observed in Parkinson's disease.
Bioinformatics: A Practical Approach (2007)

<b><i>Genome and DNA Sequence Analysis</i></b> <br><b>Genome Analysis </b> <br>Genome structure analysis by genome browser <br>Sequence similarity searching by BLAST <br><b>Two Common DNA Analysis Tools</b> <br>Restriction mapping <br>PCR application <br><b>Phylogenetics Analysis</b> <br>Multiple sequence alignments <br>Building phylogenetics tree <br><b>SNP and Haplotype Analysis </b> <br>SNP analysis <br>Haplotype analysis <br><b><i>Transcriptome and RNA Sequence Analysis</i></b> <br><b>Gene Expression Profiling by Microarray</b> <br>Experimental design <br>Da
Integrated enzyme production lowers the cost of cellulosic ethanol (2016)

Abstract Previous studies of cellulosic‐ethanol production have shown that the cost of producing cellulase is surprisingly significant, and that reducing this cost is key to making cellulosic‐ethanol economically viable. This study confirms that finding, and compares the costs of the three approaches for producing cellulase: off‐site, on‐site, and integrated. It finds that the integrated method is the lowest cost, primarily because it substitutes an inexpensive feedstock, biomass, for a relatively expensive one, glucose. This substitution also makes the ethanol a 100% second‐generation biofuel, i.e., it uses no ‘food for fuel’. This study also compares the activity of cellulase produced by the integrated method versus that produced by the off‐site method. Laboratory trials of the two show the ‘integrated’ cellulase to be better or equal to commercially available ‘off‐site’ cellulase in converting cellulose to sugar. © 2016 The Authors. Biofuels, Bioproducts, Biorefining published by Society of Chemical Industry and John Wiley & Sons, Ltd.
Frozen light in periodic metamaterials (2006)

Wave propagation in spatially periodic media, such as photonic crystals, can be qualitatively different from any uniform substance. The differences are particularly pronounced when the electromagnetic wavelength is comparable to the primitive translation of the periodic structure. In such a case, the periodic medium cannot be assigned any meaningful refractive index. Still, such features as negative refraction and/or opposite phase and group velocities for certain directions of light propagation can be found in almost any photonic crystal. The only reservation is that unlike hypothetical uniform left-handed media, photonic crystals are essentially anisotropic at frequency range of interest. Consider now a plane wave incident on a semi-infinite photonic crystal. One can assume, for instance, that in the case of positive refraction, the normal components of the group and the phase velocities of the transmitted Bloch wave have the same sign, while in the case of negative refraction, those components have opposite signs. What happens if the normal component of the transmitted wave group velocity vanishes? Let us call it a "zero-refraction" case. At first sight, zero normal component of the transmitted wave group velocity implies total reflection of the incident wave. But we demonstrate that total reflection is not the only possibility. Instead, the transmitted wave can appear in the form of an abnormal grazing mode with huge amplitude and nearly tangential group velocity. This spectacular phenomenon is extremely sensitive to the frequency and direction of propagation of the incident plane wave. These features can be very attractive in numerous applications, such as higher harmonic generation and wave mixing, light amplification and lasing, highly efficient superprizms, etc.
Role of the β subunit of casein kinase‐2 on the stability and specificity of the recombinant reconstituted holoenzyme (1992)

Recombinant human alpha subunit from casein kinase-2 (CK-2) was subjected, either alone or in combination with recombinant human beta subunit, to high temperature, tryptic digestion and urea treatment. In all three cases, it was shown that the presence of the beta subunit could drastically reduce the loss of kinase activity, strongly suggesting a protective function for the beta subunit. Assaying different peptides for specificity toward the recombinant alpha subunit and the recombinant reconstituted enzyme, showed that the presence of the beta subunit could modify the specificity of the catalytic alpha subunit. Therefore, a dual function for the beta subunit is proposed which confers both specificity and stability to the catalytic alpha subunit within the CK-2 holoenzyme complex. The peptide DLEPDEELEDNPNQSDL, reproducing the highly acidic amino acid 55-71 segment of the human beta subunit, counteracts the stimulatory effect of the beta subunit on the alpha subunit activity and partially substitutes the beta subunit in conferring thermal stability to the alpha subunit. No such effect is induced by the peptide MSSSEEVSW, reproducing the N-terminal segment of the beta subunit including the autophosphorylation site. It is suggested that the acidic domain of the beta subunit, encompassing residues 55-71, plays a role in the interactions between the beta and alpha subunits.
Design and Flight Testing of Inflatable Wings with Wing Warping (2005)

<div class="htmlview paragraph">The paper presents work on testing of inflatable wings for unmanned aerial vehicles (UAVs). Inflatable wing history and recent research is discussed. Design and construction of inflatable wings is then covered, along with ground and flight testing. Discussions include predictions and correlations of the forces required to warp (twist) the wings to a particular shape and the aerodynamic forces generated by that shape change. The focus is on characterizing the deformation of the wings and development of a model to accurately predict deformation. Relations between wing stiffness and internal pressure and the impact of external loads are presented. Mechanical manipulation of the wing shape on a test vehicle is shown to be an effective means of roll control. Possible benefits to aerodynamic efficiency are also discussed.</div>
Blood-Retinal Barrier (2010)

The blood-ocular barrier system is formed by 2 main barriers: the blood-aqueous barrier and the blood-retinal barrier (BRB). The BRB is particularly tight and restrictive and is a physiologic barrier that regulates ion, protein, and water flux into and out of the retina. The BRB consists of inner and outer components, the inner BRB being formed of tight junctions between retinal capillary endothelial cells and the outer BRB of tight junctions between retinal pigment epithelial cells. The BRB is essential to maintaining the eye as a privileged site and is essential for normal visual function. Methods of clinical evaluation of the BRB are reviewed and new directions using optical coherence tomography are presented. Alterations of the BRB play a crucial role in the development of retinal diseases. The 2 most frequent and relevant retinal diseases, diabetic retinopathy and age-related macular degeneration (AMD), are directly associated with alterations of the BRB. Diabetic retinopathy is initiated by an alteration of the inner BRB and neovascular AMD is a result of an alteration of the outer BRB. Macular edema is a direct result of alterations of the BRB.
Development of a Self-Cloning System for <i>Actinomadura verrucosospora</i> and Identification of Polyketide Synthase Genes Essential for Production of the Angucyclic Antibiotic Pradimicin (1999)

A self-cloning system for Actinomadura verrucosospora, a producer of the angucyclic antibiotic pradimicin A (PRM A), has been developed. The system is based on reproducible and reliable protoplasting and regeneration conditions for A. verrucosospora and a novel plasmid vector that consists of a replicon from a newly found Actinomadura plasmid and a selectable marker cloned from the Actinomadura strain. The system has an efficiency of more than 10(5) CFU/microgram of DNA. Using this system, we have cloned and identified the polyketide synthase (PKS) genes essential for PRM A biosynthesis from A. verrucosospora. Nucleotide sequence analysis of the 3.5-kb SalI-SphI fragment showed that ketosynthase subunits (open reading frame 1 [ORF1] and ORF2) of the essential PKS genes have strong similarities (59 to 89%) to those for angucyclic antibiotic biosynthesis.
Enhancement of Solar Water Pasteurization with Reflectors (1999)

A simple and reliable method that could be used in developing countries to pasteurize milk and water with solar energy is described. A cardboard reflector directs sunshine onto a black jar, heating water to pasteurizing temperatures in several hours. A reusable water pasteurization indicator verifies that pasteurization temperatures have been reached.
Operation of an Improved, Continuous Annular Chromatograph (1978)

Abstract A rotating annular chromatograph has been demonstrated to have utility in the continuous separation of solutes in a feed stream. Recent modifications to the system have resulted in a more efficient separation. Design of the inlet and the exit has been significantly changed to improve chromatograph performance. Refinements have also been made to the method of gradient elution. The effects of changing superficial velocity and initial resin loading on the height equivalent to a theoretical plate are shown for the ternary nickel-cobalt carbonate amine system. A continuous separation of this ternary mixture utilizing pH gradient elution is presented.
An Improved Analysis of Reliability and Entropy for Delay PUFs (2018)

Physically <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">unclonable functions</i> (PUF) have been used in various applications, such as device authentication, secure storage of sensitive data, and anti-counterfeiting. Different applications require various levels of reliability from the PUF. However, as of today, no <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">predictive</i> model to characterize the PUF reliability has been developed. This is particularly a problem for PUFs with low error rates, because the lower the error rate, the larger the number of measurements required to obtain a good estimate. In this paper, we develop a predictive framework, which enables us to derive a closed-form expression of both <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">entropy</i> and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reliability</i> for several families of delay PUFs: the ring oscillator (RO) PUF, the RO sum PUF as well as the Loop PUF. Improving reliability with bit-filtering, we provide an explicit tradeoff between complexity, reliability and entropy. Error rates as low as 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> or even lower can be achieved. Our theoretical results are validated by experiments on Loop PUFs implemented in 65 nm CMOS ASIC technology, also used to simulate the behavior of the RO PUF and the RO sum PUF.
Identification of noninvasive imaging surrogates for brain tumor gene-expression modules (2008)

Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults. We combined neuroimaging and DNA microarray analysis to create a multidimensional map of gene-expression patterns in GBM that provided clinically relevant insights into tumor biology. Tumor contrast enhancement and mass effect predicted activation of specific hypoxia and proliferation gene-expression programs, respectively. Overexpression of EGFR, a receptor tyrosine kinase and potential therapeutic target, was also directly inferred by neuroimaging and was validated in an independent set of tumors by immunohistochemistry. Furthermore, imaging provided insights into the intratumoral distribution of gene-expression patterns within GBM. Most notably, an "infiltrative" imaging phenotype was identified that predicted patient outcome. Patients with this imaging phenotype had a greater tendency toward having multiple tumor foci and demonstrated significantly shorter survival than their counterparts. Our findings provide an in vivo portrait of genome-wide gene expression in GBM and offer a potential strategy for noninvasively selecting patients who may be candidates for individualized therapies.
CRM System Based on Uni-Queue CTI Middleware (2007)

The CTI(computer telecommunication integration) middleware,important software of synergic CRM system,needs to manage different communication channels,such as telephone,E-mail and Web request.CTI also needs to route the request to correct agent,based on information of request,technic skill and work state of agent.This article describes a synergic CRM system by Uni-Queue CTI which supports multimedia router,and discusses inside media server module of the CTI software.
Expanding automotive electronic systems (2002)

A vast increase in automotive electronic systems, coupled with related demands on power and design, has created an array of new engineering opportunities and challenges. Today's high-end vehicles may have more than 4 kilometers of wiring, compared to 45 meters in vehicles manufactured in 1955. Reducing wiring mass through in-vehicle networks will bring an explosion of new functionality and innovation. Our vehicles will become more like PCs, creating the potential for a host of plug-and-play devices. On average, US commuters spend 9 percent of their day in an automobile. Thus, introducing multimedia and telematics to vehicles will increase productivity and provide entertainment for millions. Further, X-by-wire solutions will make computer diagnostics a standard part of mechanics' work and may even create an electronic chauffeur.
Machine-to-Machine Communication in LTE-A (2010)

Wireless equipped machines are increasing greatly in recent years, among which the cellular network based machine-to-machine communication (M2M) has shown the advantages of better coverage and lower network deployment cost. However, the current cellular network is designed for human-to-human communication, targeting the voice/media transmission with low access delay and high throughput, so the machines in GSM and UMTS are designed like a screenless phone. To extend the market to machine type communication, it is envisaged that the specific optimizations for M2M will be introduced in LTE-A, especially when M2M communication accounts for the considerable part in the total networking activities. In this paper, some of the considerations of the network side improvements are presented, from the physical layer, MAC to core network.
Deterioration of soya-bean oil: quantification of primary flavour compounds using a stable isotope dilution assay. (1990)

A stable isotope dilution assay was developed for the quantification of hexanol, (Z)-3-hexenal, 1-octen-3-one, (Z)-1,5-octadien-3-one, 1-octen-3-hydroperoxide, (E)-2-nonenal, (Z)-2-nonenal, (E,Z)-2,6-nonadienal, (E,E)-2,4-decadienal, trans-4,5-epoxy-(E)-2-decenal, and 3-methyl-2,4-nonandione. The oil sample was spiked with the synthesized deuterated internal standards, and the volatile fraction was separated by HPLC. Each fractions isolated was analysed by capillary GC/MS. The procedure was applied to soybean oil samples stored in the presence and absence of light at room temperature. The data obtained were compared with the taste threshold data.