gebhart/patrepeval huggingface dataset:
Wrapping oligomers and polymers around metal atoms, metal clusters, and metal colloids (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWrapping oligomers and polymers around metal atoms, metal clusters, and metal colloidsMark P. Andrews and Geoffrey A. OzinCite this: Chem. Mater. 1989, 1, 2, 174–187Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/cm00002a004https://doi.org/10.1021/cm00002a004research-articleACS PublicationsRequest reuse permissionsArticle Views238Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The effect of acylated polyamine derivatives on polyamine uptake mechanism, cell growth, and polyamine pools in <i>Escherichia coli</i>, and the pursuit of structure/activity relationships (1998)

Two acetyl analogues of spermidine and five analogues of spermine were used to determine the structural specificity of the polyamine transport system in Escherichia coli by measuring their ability to compete with [14C]putrescine or [14C]spermine for uptake, as well as to inhibit cell growth, and, finally, to affect the intracellular polyamine pools. Spermine uptake follows simple Michaelis-Menten kinetics (Kt = 24.58 +/- 2.24 microM). In contrast, the putrescine uptake system involves two saturable Michaelis-Menten carriers exhibiting different affinity towards putrescine (Kt = 3.63 +/- 0.43 microM, Kt' = 0.61 +/- 0.10 microM). From the Ki values, it is inferred that N1-5-amino-2-nitrobenzoylspermine is the most effective competitive inhibitor followed by N1-acetylspermine, and then N1,N12-diacetylspermine. N1-acetylspermidine and N8-acetylspermidine also inhibit competitively the uptake of spermine, the latter being the most effective inhibitor. In addition, the above-mentioned analogues inhibit identically one of the carriers of putrescine uptake, suggesting the existence of a common transporter for both putrescine and spermine. The order of analogue potency, regarding the other carrier of putrescine is as follows: N1,N12-diacetylspermine approximately N1-5-amino-2-nitro-benzoylspermine > N1-acetylspermine. Both N1-acetylspermidine (Ki = 753 +/- 25 microM, Ki' = 128 +/- 5 microM) and N8-acetylspermidine (Ki = 22.4 +/- 0.4 microM, Ki' = 279 +/- 3 microM) also cause competitive inhibition of putrescine uptake, however with inverse affinity towards the putrescine carriers. Neither N4,N9-diacetylspermine, nor N1,N4-bis(beta-alanyl)diaminobutane affect the uptake of any polyamine. Interestingly, none of the acetyl analogues of spermine has a measurable effect on cell growth and cellular polyamine pools, although some of them are accumulated in cells. Based on these findings, the relative significance of the primary and secondary amines and of the chain flexibility as determinants of cellular uptake are discussed.
Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (<i>ob/ob</i>) mice (2006)

The transcription factor carbohydrate response element-binding protein (ChREBP) mediates insulin-independent, glucose-stimulated gene expression of multiple liver enzymes responsible for converting excess carbohydrate to fatty acids for long-term storage. To investigate ChREBP's role in the development of obesity and obesity-associated metabolic dysregulation, ChREBP-deficient mice were intercrossed with ob/ob mice. As a result of deficient leptin expression, ob/ob mice overeat, become obese and resistant to insulin, and display marked elevations in hepatic lipogenesis, gluconeogenesis, and plasma glucose and triglycerides. mRNA expression of all hepatic lipogenic enzymes was significantly lower in ob/ob-ChREBP-/- than in ob/ob mice, resulting in decreased hepatic fatty acid synthesis and normalization of plasma free fatty acid and triglyceride levels. Overall weight gain in addition to adiposity was reduced in the doubly deficient mice. The former was largely attributable to decreased food intake and may result from decreased hypothalamic expression of the appetite-stimulating neuropeptide agouti-related protein. mRNA expression and activity of gluconeogenic enzymes also was lower in the doubly deficient mice, contributing to significantly lower blood glucose levels. The results of this study suggest that inactivation of ChREBP expression not only reduces fat synthesis and obesity in ob/ob mice but also results in improved glucose tolerance and appetite control.
Enhanced SLAMF7 Homotypic Interactions by Elotuzumab Improves NK Cell Killing of Multiple Myeloma (2019)

Elotuzumab (Elo) is an IgG<sub>1</sub> monoclonal antibody targeting SLAMF7 (CS1, CRACC, and CD319), which is highly expressed on multiple myeloma (MM) cells, natural killer (NK) cells, and subsets of other leukocytes. By engaging with FcγRIIIA (CD16), Elo promotes potent NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) and macrophage-mediated antibody-dependent cellular phagocytosis (ADCP) toward SLAMF7<sup>+</sup> MM tumor cells. Relapsed/refractory MM patients treated with the combination of Elo, lenalidomide, and dexamethasone have improved progression-free survival. We previously showed that Elo enhances NK cell activity via a costimulation mechanism, independent of CD16 binding. Here, we further studied the effect of Elo on cytotoxicity of CD16-negative NK-92 cells. Elo, but not other SLAMF7 antibodies, uniquely enhanced cytotoxicity mediated by CD16-negative NK-92 cells toward SLAMF7<sup>+</sup> target cells. Furthermore, this CD16-independent enhancement of cytotoxicity required expression of SLAMF7 containing the full cytoplasmic domain in the NK cells, implicating costimulatory signaling. The CD16-independent costimulation by Elo was associated with increased expression of NKG2D, ICAM-1, and activated LFA-1 on NK cells, and enhanced cytotoxicity was partially reduced by NKG2D blocking antibodies. In addition, an Fc mutant form of Elo that cannot bind CD16 promoted cytotoxicity of SLAMF7<sup>+</sup> target cells by NK cells from most healthy donors, especially if previously cultured in IL2. We conclude that in addition to promoting NK cell-mediated ADCC (CD16-dependent) responses, Elo promoted SLAMF7-SLAMF7 interactions in a CD16-independent manner to enhance NK cytotoxicity toward MM cells.
A New Method for Preparation of Alcohols from Olefins with Molecular Oxygen and Phenylsilane by the Use of Bis(acetylacetonato)cobalt(II) (1989)

Abstract In the presence of a catalytic amount of bis(acetylacetonato)cobalt(II), various olefins react smoothly with molecular oxygen and phenylsilane at room temperature to afford the corresponding alcohols in good yields under neutral conditions.
Decreased transient outward K+ current in ventricular myocytes from acromegalic rats (1991)

Cardiac hypertrophy and heart failure are common to acromegalic patients who have abnormally high serum growth hormone (GH). While the function of cardiac muscle is clearly affected by chronically elevated GH, the electrical activity of myocytes from hearts with GH-dependent hypertrophy has not been studied. We used adult, female Wistar-Furth rats with induced GH-secreting tumors to study the effect of excessive GH on ion channels of cardiac myocytes. GH-secreting tumors were induced by subcutaneous inoculation of GH3 cells. Eight weeks after inoculation, the rats had doubled their body weight and heart size compared with age-matched controls. There were no differences in either action potential amplitude or resting potential of right ventricular myocytes from control and tumor-bearing rats. However, action potential duration increased significantly in tumor-bearing rats; the time to 50% repolarization was 23 +/- 14 ms (n = 10) compared with 6.6 +/- 1.5 ms (n = 14) in controls. The prolongation of the action potential was mainly due to a decrease in density of a transient outward current (It,o) carried by K+. The normalized conductance for It,o decreased from 0.53 +/- 0.10 nS/pF (n = 25) in controls to 0.33 +/- 0.09 nS/pF (n = 26) in tumor-bearing rats. The decrease in It,o) and increase in heart weight occurred with a similar time course. The increased action potential duration prolongs Ca2+ influx through L-type Ca2+ channels in the tumor-bearing animals; this may be important in cardiovascular adaptation.
Evaluation of Cryptography Usage in Android Applications (2016)

Mobile application developers are using cryptography in their products to protect sensitive data like passwords, short messages, documents etc. In this paper, we study whether cryptography and related techniques are employed in a proper way, in order to protect these private data. To this end, we do
Arteriovenous Brain Malformations: Is Functional MR Imaging Reliable for Studying Language Reorganization in Patients? Initial Observations (2002)

These data suggest that flow abnormalities may interfere with language lateralization assessment with functional MR imaging.
LTE enhancements for Public Safety and Security\ncommunications to support Group Multimedia\nCommunications (2016)

Currently Public Safety and Security communication systems rely on reliable and secure Professional Mobile Radio (PMR) Networks that are mainly devoted to provide voice services. However, the evolution trend for PMR networks is towards the provision of new value-added multimedia services such as video streaming, in order to improve the situational awareness and enhance the life-saving operations. The challenge here is to exploit the future commercial broadband networks to deliver voice and multimedia services satisfying the PMR service requirements. In particular, a viable solution till now seems that of adapting the new Long Term Evolution technology to provide IP-based broadband services with the security and reliability typical of PMR networks. This paper outlines different alternatives to achieve this goal and, in particular, proposes a proper solution for providing multimedia services with PMR standards over commercial LTE networks.
Low Cost and Portable PCR Thermoelectric Cycle (2008)

In this work, we develop a rapid polymerase chain reaction (PCR) device with thermoelectric cooling for the fast PCR thermo cycling process. The PCR system utilizes a 60W commercial thermoelectric module, the Tianjin TEC1-12710 model, which allows fast heating and rapid cooling in the PCR temperature cycles. In this study, the system performance has been tested with DNA of shigella spp bacteria. The results are compared to the results of a commercial PCR system (Thermo cycle) operated under the same PCR parameters including initial amount of DNA, the number of cycles, temperature and time in each PCR step. The experimental results show that DNA ampliflcation is successful with expected amount of the amplifled DNAs that is comparable to those from the commercial PCR system.
Inactivation of the AIDS-Causing Retrovirus and Other HumanViruses in Antihemophilic Plasma Protein Preparations byPasteurization (1986)

Heat treatment at 60°C for 10 h in solution (pasteurization) was introduced into the manufacturing process of antihemophilic cryoprecipitate (AHC) and factor VIII concentrates (F VIII) to reduce the risk of transmission of hepatitis to hemophiliacs. Since the acquired immunodeficiency syndrome (AIDS) may also be transmitted to hemophiliacs by antihemophilic plasma protein preparations, we have investigated inactivation of the AIDS virus HTLV III by pasteurization in AHC or F VIII and included in this study cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus (HSV), poliovirus and vaccinia virus. Each of these viruses was efficiently inactivated by pasteurization although considerable differences were observed between the different viruses. HTLV III was rapidly inactivated, becoming nondetectable within 30-60 min. Our findings indicate that pasteurized AHC or F VIII should have a high margin of safety regarding the transmission of AIDS or any other infectious disease caused by viruses such as those tested.
Elemental Design Patterns: A Link Between Architecture and Object Semantics (2002)

Lacrimal probe and D-silicone intubation appear to be a feasible, minimally invasive, safe, and effective method, which could be a reasonable choice in the treatment of AD.
Full-aperture wavefront reconstruction from annular subaperture interferometric data by use of Zernike annular polynomials and a matrix method for testing large aspheric surfaces (2006)

We propose a more accurate and efficient reconstruction method used in testing large aspheric surfaces with annular subaperture interferometry. By the introduction of the Zernike annular polynomials that are orthogonal over the annular region, the method proposed here eliminates the coupling problem in the earlier reconstruction algorithm based on Zernike circle polynomials. Because of the complexity of recurrence definition of Zernike annular polynomials, a general symbol representation of that in a computing program is established. The program implementation for the method is provided in detail. The performance of the reconstruction algorithm is evaluated in some pertinent cases, such as different random noise levels, different subaperture configurations, and misalignments.
Characterization and Development of Advanced Heat Transfer Technologies (2009)

This presentation gives an overview of the status and FY09 accomplishments for the NREL thermal management research project 'Characterization and Development of Advanced Heat Transfer Technologies'.
<title>Multilingual information retrieval system</title> (1996)

In this paper, we present an approach in implementing intelligent information retrieval systems. We have constructed a multilingual information system which combines both image and text retrieval. We have developed an English/Chinese text retrieval tool on the WWW, and later incorporated an image retrieval tool based on associated multilingual captions. The system allows the general public to locate and keep abreast of information about Singapore. It has a novel user interface which accepts queries that are expressed in English, Chinese and mixed text into its database. The titles, summaries, URLs and the matching scores of retrieved documents will then be returned, and a thumbnail will be displayed as well if an image document is retrieved.
Antigenic Analysis Of Current Wild Type And Vaccine Strains Of Measles Virus (1994)

The antigenic properties of vaccine and wild type strains of measles virus were compared. Serum specimens from vaccinated persons, persons infected during the prevaccine era, or mice experimentally vaccinated with the hemagglutinin (H) protein from vaccine virus neutralized vaccine virus and a wild type measles virus from 1989 equally well. In contrast, serum specimens from patients with recent measles virus infection and mice experimentally vaccinated with the H protein from the wild type virus from 1989 neutralized wild type virus with titers 4-8 times higher than those to vaccine virus. Several H protein-specific monoclonal antibodies could differentially recognize vaccine or wild type virus. These data show that the H proteins of the recent wild type viruses contain both conserved and new or modified antigenic determinants and are consistent with previous studies that described genetic drift in the H proteins of recent wild type viruses.
Improving Classifier Performance Using Data with Different Taxonomies (2010)

We propose a framework for improving classifier performance by effectively using auxiliary samples. The auxiliary samples are labeled not in terms of the target taxonomy according to which we wish to classify samples, but according to classification schemes or taxonomies that are different from the target taxonomy. Our method finds a classifier by minimizing a weighted error over the target and auxiliary samples. The weights are defined so that the weighted error approximates the expected error when samples are classified into the target taxonomy. Experiments using synthetic and text data show that our method significantly improves the classifier performance in most cases compared to conventional data augmentation methods.
Sildenafil Increases the p50 and Shifts the Oxygen–Hemoglobin Dissociation Curve to the Right (2015)

Sildenafil caused a dose-dependent increase in the release of oxygen from the erythrocytes as shown by the increased p50 values and rightward shift of the oxygen-hemoglobin dissociation curve. Ellis SS and Pepple DJ. Sildenafil increases the p50 and shifts the oxygen-hemoglobin dissociation curve to the right.
Clot volume and clearance rate as independent predictors of vasospasm after aneurysmal subarachnoid hemorrhage (2004)

Quantitative analysis of subarachnoid clot shows that vasospasm is best predicted by initial subarachnoid clot volume and the percentage of clot cleared per day.
Simultaneous Interpenetrating Networks Prepared from Special Functional Group Triglyceride Oils (1984)

Lesquerella palmeri is an oil-bearing wildflower that grows in the deserts of the western United States. The structure of the oil from this plant is similar to that of castor oil and contains hydroxyl groups. These hydroxyl groups can be reacted with sebacic acid (decanedioic acid) or toluene 2,4-diisocyanate to form polyesters or polyurethanes. If both cross-linkers are used, a mixed polyester-polyurethane is formed. Several interpenetrating polymer networks (IPNs) and simultaneous interpenetrating networks (SINs) with divinylbenzene (DVB) were made. The morphology of these samples depends on the method of synthesis; the sequential IPNs have smaller domains than the SINs. Modulus-temperature studies on a number of compositions show that the SINs and IPNs are tough, leathery materials in the midrange compositions.
Transient permeabilization of airway epithelium by mucosal water (1996)

We describe a simple hyposmotic shock procedure whereby the apical membrane of airway epithelium can be made transiently leaky to proteins and other macromolecules. Bovine or human tracheal epithelial cells were grown as confluent polarized cell sheets on porous inserts. While physiological saline was maintained on the basolateral surface, the mucosal surface was exposed to water. This led to marked increases in the uptake of [14C]mannitol across both apical and basolateral membranes. On restoring saline to the mucosal surface, the [14C]mannitol permeability returned to preexposure levels with a half-life of approximately 5 min. Mucosal water also increased efflux of lactate dehydrogenase and the uptakes of fluorescent albumin and dextran (2,000 kDa). Water-induced increases in mannitol permeability were similar at 4 and 37 degrees C, suggesting that pinocytosis was not the mechanism. Detailed time courses of the uptake of dextran and the loss of lactate dehydrogenase and 36Cl showed that the bulk of the permeability increase occurred during the first 2- to 4-min exposure to water. Transepithelial resistance was reversibly decreased by exposure to water, but short-circuit current responses to transport blockers and secretagogues remained qualitatively normal. The hyposmotic shock procedure also successfully permeabilized apical membranes of primary cultures of nasal epithelial cells from a patient with cystic fibrosis (CF) and of JME/CF 15 cells, a cell line derived from CF bronchial epithelium. This simple and efficient procedure may prove useful in studies on the cell and molecular biology of airway and other epithelia.
The Properties and Reactions of Perfluorobutyrolactone (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Properties and Reactions of PerfluorobutyrolactoneMurray Hauptschein, Charles S. Stokes, and Aristid V. GrosseCite this: J. Am. Chem. Soc. 1952, 74, 8, 1974–1976Publication Date (Print):April 1, 1952Publication History Published online1 May 2002Published inissue 1 April 1952https://pubs.acs.org/doi/10.1021/ja01128a030https://doi.org/10.1021/ja01128a030research-articleACS PublicationsRequest reuse permissionsArticle Views162Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Slow Down and Survive: Enigmatic Immunoregulation by BTLA and HVEM (2010)

B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. Its ligand, herpesvirus entry mediator (HVEM), is a tumor necrosis factor receptor superfamily member. The unique interaction between BTLA and HVEM allows for a system of bidirectional signaling that must be appropriately regulated to balance the outcome of the immune response. HVEM engagement of BTLA produces inhibitory signals through SH2 domain-containing protein tyrosine phosphatase 1 (Shp-1) and Shp-2 association, whereas BTLA engagement of HVEM produces proinflammatory signals via activation of NF-kappaB. The BTLA-HVEM interaction is intriguing and quite complex given that HVEM has four other ligands that also influence immune responses, the conventional TNF ligand LIGHT and lymphotoxin alpha, as well as herpes simplex virus glycoprotein D and the glycosylphosphatidylinositol-linked Ig domain protein CD160. BTLA-HVEM interactions have been shown to regulate responses in several pathogen and autoimmune settings, but our understanding of this complex system of interactions is certainly incomplete. Recent findings of spontaneous inflammation in BTLA-deficient mice may provide an important clue.