gebhart/patrepeval huggingface dataset:
Pancreas preservation for pancreas and islet transplantation (2008)

Purpose of review To summarize advances and limitations in pancreas procurement and preservation for pancreas and islet transplantation, and review advances in islet protection and preservation. Recent findings Pancreases procured after cardiac death, with in-situ regional organ cooling, have been successfully used for islet transplantation. Colloid-free Celsior and histidine-tryptophan-ketoglutarate preservation solutions are comparable to University of Wisconsin solution when used for cold storage before pancreas transplantation. Colloid-free preservation solutions are inferior to University of Wisconsin solution for pancreas preservation prior to islet isolation and transplantation. Clinical reports on pancreas and islet transplants suggest that the two-layer method may not offer significant benefits over cold storage with the University of Wisconsin solution: improved oxygenation may depend on the graft size; benefits in experimental models may not translate to human organs. Improvements in islet yield and quality occurred from pancreases treated with inhibitors of stress-induced apoptosis during procurement, storage, isolation or culture. Pancreas perfusion may be desirable before islet isolation and transplantation and may improve islet yields and quality. Methods for real-time, noninvasive assessment of pancreas quality during preservation have been implemented and objective islet potency assays have been developed and validated. These innovations should contribute to objective evaluation and establishment of improved pancreas preservation and islet isolation strategies. Summary Cold storage may be adequate for preservation before pancreas transplants, but insufficient when pancreases are processed for islets or when expanded donors are used. Supplementation of cold storage solutions with cytoprotective agents and perfusion may improve pancreas and islet transplant outcomes.
Generation of 2.5 Gbit/s soliton data stream withan integrated laser-modulatortransmitter (1994)

An electroabsorption modulator integrated with a DBR laser and driven with a dual gate FET forms a transform-limited, wavelength-tunable soliton transmitter. Back-to-back bit error rate measurements at 2.5 Gbit/s are reported.
[Experssion of human glutathione-S-transferase A1 in CHO cells]. (2007)

The CHO-GSTA1 was constructed and for research purification protein and candidate strains of detoxicitic mechanism of chemical toxins and carcinogenesis.
Three-dimensional echocardiography by semi-automatic border detection in assessment of left ventricular volume and ejection fraction: comparison with magnetic resonance imaging. (1997)

The feasibility of three-dimensional echocardiographic reconstruction by semi-automatic border detection to assess left ventricular volume and function was investigated in a clinically applicable setting in 23 patients with various cardiac diseases and 7 normal volunteers. The commercial equipment permits digital acquisition of three apical orthogonal views, manual tracing of end-diastolic and end-systolic endocardium, semi-automatic border extractions of other frames, three-dimensional echocardiographic reconstruction and dynamic display within 20 min in a low resolution mode. Correlation of measurements with data obtained by magnetic resonance imaging (MRI) using the biplane modified Simpson method showed left ventricular end-diastolic volume (y = 0.894x - 0.456, r = 0.925, p < 0.001), end-systolic volume (y = 1.09x - 8.98, r = 0.959, p < 0.001), and ejection fraction (y = 0.956x + 1.93, r = 0.851, p < 0.001). In addition, a dynamic three-dimensional "movie-like" image displayed the shape, geometry, and regional wall motion abnormality, and change in global shape and size of the left ventricle. Three-dimensional echocardiographic analysis by three apical orthogonal views and dynamic display of the left ventricle provides reliable data comparable to MRI measurements within a reasonable period of time, and is now clinically feasible.
ChemInform Abstract: Synthesis, Chiral Resolution, and Determination of Novel Furan Lignan Derivatives with Potent Antitumor Activity. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Strategies to deliver microRNAs as potential therapeutics in the treatment of cardiovascular pathology (2012)

Development of new miRNA carrier systems with advanced properties and large animal data in the cardiovascular field is highly recommended.
PREDICTION AND MONITORING OF TYRE/ROAD FRICTION (1992)

This article presents research which is investigating a method for monitoring and predicting the tyre-road friction coefficient. A specially instrumented car has been designed to carry out the work called DAGMAR (DArmstaedter Geraetetraeger zur Messung des Alctuellen Reibwerts). The following criteria are being investigated: 1) the correlation between tyre noise and friction. The influence of wetness and torque are both studied. The potential of noise measurement for friction detection is discussed; and 2) the correlation between tyre tread deformation and tyre/road friction. Brief details are provided of the experimental design and the results from each type of experiment. A model for forecasting the friction coefficient using these data is presented and discussed. The system is part of the work being carried out under PROMETHEUS and IMES programmes to design driver support systems, and automatic intelligent vehicle control. For the covering abstract see IRRD 869205.
The Herpes Simplex Virus 1 Latency-Associated Transcript Promotes Functional Exhaustion of Virus-Specific CD8 <sup>+</sup> T Cells in Latently Infected Trigeminal Ganglia: a Novel Immune Evasion Mechanism (2011)

Following ocular herpes simplex virus 1 (HSV-1) infection of C57BL/6 mice, HSV-specific (HSV-gB(498-505) tetramer(+)) CD8(+) T cells are induced, selectively retained in latently infected trigeminal ganglia (TG), and appear to decrease HSV-1 reactivation. The HSV-1 latency-associated transcript (LAT) gene, the only viral gene that is abundantly transcribed during latency, increases reactivation. Previously we found that during latency with HSV-1 strain McKrae-derived viruses, more of the total TG resident CD8 T cells expressed markers of exhaustion with LAT(+) virus compared to LAT(-) virus. Here we extend these findings to HSV-1 strain 17syn+-derived LAT(+) and LAT(-) viruses and to a virus expressing just the first 20% of LAT. Thus, the previous findings were not an artifact of HSV-1 strain McKrae, and the LAT function involved mapped to the first 1.5 kb of LAT. Importantly, to our knowledge, we show here for the first time that during LAT(+) virus latency, most of the HSV-1-specific TG resident CD8 T cells were functionally exhausted, as judged by low cytotoxic function and decreased gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α) production. This resulted in LAT(-) TG having more functional HSV-gB(498-505) tetramer(+) CD8(+) T cells compared to LAT(+) TG. In addition, LAT expression, in the absence of other HSV-1 gene products, appeared to be able to directly or indirectly upregulate both PD-L1 and major histocompatibility complex class I (MHC-I) on mouse neuroblastoma cells (Neuro2A). These findings may constitute a novel immune evasion mechanism whereby the HSV-1 LAT directly or indirectly promotes functional exhaustion (i.e., dysfunction) of HSV-specific CD8(+) T cells in latently infected TG, resulting in increased virus reactivation.
Drug release profiles in the shrinking process of thermoresponsive poly(N-isopropylacrylamide-co-alkyl methacrylate) gels (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDrug release profiles in the shrinking process of thermoresponsive poly(N-isopropylacrylamide-co-alkyl methacrylate) gelsRyo Yoshida, Kiyotaka Sakai, Teruo Okano, and Yasuhisa SakuraiCite this: Ind. Eng. Chem. Res. 1992, 31, 10, 2339–2345Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/ie00010a013https://doi.org/10.1021/ie00010a013research-articleACS PublicationsRequest reuse permissionsArticle Views362Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Frequency and Time Domain Crosstalk Signal Analysis for Integrated High-Density Circuits (2009)

Crosstalk is one of the greatest concerns in the design of integrated high-density circuits, especially in high frequency range, due to that it seriously leads to a wireless communication system deviating from its designed performance. In this paper, we analyze the frequency and time domain crosstalk effects between two traces as a function of their spacing and orientation. It is found that two vertical traces result in a smallest crosstalk and that the crosstalk signals are insensitive to the spacing increment between two parallel traces in the range investigated.
Training Neural Networks with Stochastic Hessian-Free Optimization (2013)

Hessian-free (HF) optimization has been successfully used for training deep autoencoders and recurrent networks. HF uses the conjugate gradient algorithm to construct update directions through curvature-vector products that can be computed on the same order of time as gradients. In this paper we exploit this property and study stochastic HF with gradient and curvature mini-batches independent of the dataset size. We modify Martens' HF for these settings and integrate dropout, a method for preventing co-adaptation of feature detectors, to guard against overfitting. Stochastic Hessian-free optimization gives an intermediary between SGD and HF that achieves competitive performance on both classification and deep autoencoder experiments.
Ring-fluorinated prostaglandins: total synthesis of (.+-.)-10.alpha.-fluoroprostaglandin F2.alpha. methyl ester (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing-fluorinated prostaglandins: total synthesis of (.+-.)-10.alpha.-fluoroprostaglandin F2.alpha. methyl esterPaul A. Grieco, Eric Williams, and Tsutomu SugaharaCite this: J. Org. Chem. 1979, 44, 13, 2194–2199Publication Date (Print):June 1, 1979Publication History Published online1 May 2002Published inissue 1 June 1979https://pubs.acs.org/doi/10.1021/jo01327a034https://doi.org/10.1021/jo01327a034research-articleACS PublicationsRequest reuse permissionsArticle Views174Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic. (1983)

A decade of intense investigation has established a central role for lipoprotein receptors in regulating plasma cholesterol traffic. These receptors bind cholesterol-carrying lipoproteins and transport them into cells by receptor-mediated endocytosis. The receptor for low density lipoprotein (LDL) was the first discovered; it has been purified and its structure characterized. The LDL receptor was described in cultured human fibroblasts; identical receptors are now known to function in liver as well as in extrahepatic tissues. Operationally, the LDL/LDL receptor system can be considered the primary transport mechanism for endogenous cholesterol. Dietary cholesterol, on the other hand, is transported from the intestine in chylomicron remnants, which enter hepatocytes via distinct chylomicron remnant receptors. The chylomicron remnant/remnant receptor system is to exogenous cholesterol transport as the LDL/LDL receptor system is to endogenous cholesterol transport. In this article, we review recent developments in this rapidly advancing field.
Steric parameters in drug design. Monoamine oxidase inhibitors and antihistamines (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteric parameters in drug design. Monoamine oxidase inhibitors and antihistaminesEberhard Kutter and Corwin HanschCite this: J. Med. Chem. 1969, 12, 4, 647–652Publication Date (Print):July 1, 1969Publication History Published online1 May 2002Published inissue 1 July 1969https://pubs.acs.org/doi/10.1021/jm00304a020https://doi.org/10.1021/jm00304a020research-articleACS PublicationsRequest reuse permissionsArticle Views503Altmetric-Citations157LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spinal 5‐HT<sub>2</sub> receptor‐mediated facilitation of pudendal nerve reflexes in the anaesthetized cat (1996)

1. 5-Hydroxytryptamine (5-HT) is intimately associated with central sympathetic and somatic control of the lower urinary tract. The sympathetic and somatic innervation of the lower urinary tract is conveyed through efferent axons of the hypogastric and pudendal nerves, respectively. 2. The present study examined the effects of 2,5-dimethoxy-4-iodophenylisopropylamine (DOI), a 5-HT2 receptor subtype-selective agonist, on evoked potentials recorded from the central ends of the hypogastric and pudendal nerves in response to electrical stimulation of afferent fibres in the pelvic and pudendal nerves, respectively. Various spinalization paradigms were employed to localize the site of action. All cats were pretreated with xylamidine (1 mg kg-1), a peripherally-restricted 5-HT2 receptor antagonist. 3. In acute spinal cats, DOI (0.01-3 mg kg-1, i.v.) reliably produced dose-dependent increases in the pudendal nerve reflex (to 228 +/- 31% of control). These increases were reversed by the 5-HT2 receptor-selective antagonist, LY53857 (0.3-3 mg kg-1, i.v.). On the other hand, in spinally-intact cats, DOI produced no significant changes in the pudendal reflex. However, within minutes of spinalization of DOI-pretreated cats, a marked increase (to 221 +/- 16% of control) in the pudendal reflex was observed which could be reversed by LY53857. No significant effects were observed on hypogastric reflexes in either acute spinal or spinally-intact cats following DOI administration. No effects were seen in either spinally-intact or acute spinal animals when LY53857 was administered as the initial drug. 4. These results indicate that activation of spinal 5-HT2 receptors facilitates pudendal reflexes. In spinally-intact cats, it is hypothesized that DOI activates supraspinal pathways that mediate inhibition of the pudendal reflexes and counteracts the facilitatory effects of spinal 5-HT2 receptor activation.
ChemInform Abstract: BORON CHELATES OF N‐SUBSTITUTED HYDROXAMIC ACIDS (1983)

Abstract Aus der Umsetzung der N‐Alkylbzw.
Cluster Command and Control (C3) Tool Suite (2001)

The raw computation power of today's PC clusters running the Linux operating system rivals that of commercial supercomputers at a fraction of their purchase price. As a part of that high price tag, some tools and system support come with the supercomputer package . However, a multitude of vendors will slap together a number of commodity computer boxes and call it a cluster while providing nothing more than a power cord for each box. Thus, the lack of good administration and application support tools represents a hidden operation cost that is often overlooked when purchasing a cluster. This hidden cost greatly adds to the cluster's total cost of ownership. The work presented in this paper addresses the area of cluster administration and application support by presenting the Cluster Command & Control (C3) tool suite developed at Oak Ridge National Laboratory for use in administrating and using its high performance cluster computing resources. We first cover the history of the Cluster Command and Control (C3) tool suite from initial v1.0 release to present state of v2.7 and include brief directions for v3.0 as well as the planned v4.0. We then present the requisite C3 tools environment followed by C3 command specifications with command syntax and some simple command line usage examples. A brief coverage is then give to some implementation issues between a serial and parallel implementation. We conclude the discussion of C3 v2.x with advanced usage techniques by showing how the C3 tools may be embedded into other commands and applications to create end-to-end cluster solutions. We close our discussion by providing information on C3 v3.0 that will be released later in 2001, as well as plans for a v4.0 high-scalability release.
A Universal Single-stage AC-DC Front-end Resonant Converter with a New Active Current Mode Controller: Performance and Design (2007)

This paper presents the performance evaluation of an improved current mode controller for the load resonant converters suitable for the universal single-stage single phase power factor correction circuits. It has a modified active controller, which improves the performance from no-load up to full-load. The steady state characteristics are developed and a design example is given in detail. The proposed controller allows zero voltage switching (ZVS) at any loading condition with a reasonable power factor that satisfies the IEC 61000-3-2 standards together with a promising efficiency. Analytical, simulation, and experimental results verify the design validity.
A Wireless Bio-MEMS Sensor for C-Reactive Protein Detection Based on Nanomechanics (2008)

A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200-microm-long microelectromechanical systems (MEMS) microcantilever housed in a 7 x 7 mm(2) reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending on accuracy. The deflection of the microcantilever due to specific CRP-antiCRP binding is detected using a position-sensitive detector. The converted bio-signal is transmitted by a custom designed wireless amplitude-shift-keying (ASK) transceiver IC fabricated in a 0.18 microm CMOS process. CRP concentrations from 1 microg/mL to 500 microg/mL can be detected. A 0.2-Hz 1-V ac signal instead of traditional bases/acids is applied to the bio-MEMS sensor to unbind the CRP from the microcantilever for reusability.
TITAS 2012：Fashion, Function, Sustainability (2012)

Organized by the Taiwan Textile Federation (TTF), Taipei Innovative Textile Application show (TITAS) had maintained the commitment to provide one-stop-for-all services for professional buyers while being a best platform to showcase Taiwan’s innovative textiles ranging from fiber to apparel,focusing on fashion,functionality and eco-friendliness.
Much Improved Conditions for the Negishi Cross-Coupling of Iodoalanine Derived Zinc Reagents with Aryl Halides (2009)

A combination of Pd(2)(dba)(3) and SPhos (1:2 molar ratio) is an excellent precatalyst for the Negishi cross-coupling of the serine-derived organozinc reagent 2 with aryl halides, including previously difficult ortho-substituted examples. In the case of meta- and para-substituted aryl halides, Pd-loadings of 0.5 mol % give satisfactory results. Use of 2-iodoaniline as substrate gives the lactam 12 in good yield.
Investigation of thin filament near‐neighbour regulatory unit interactions during force development in skinned cardiac and skeletal muscle (2007)

Ca(2+)-dependent activation of striated muscle involves cooperative interactions of cross-bridges and thin filament regulatory proteins. We investigated how interactions between individual structural regulatory units (RUs; 1 tropomyosin, 1 troponin, 7 actins) influence the level and rate of demembranated (skinned) cardiac muscle force development by exchanging native cardiac troponin (cTn) with different ratio mixtures of wild-type (WT) cTn and cTn containing WT cardiac troponin T/I + cardiac troponin C (cTnC) D65A (a site II inactive cTnC mutant). Maximal Ca(2+)-activated force (F(max)) increased in less than a linear manner with WT cTn. This contrasts with results we obtained previously in skeletal fibres (using sTnC D28A, D65A) where F(max) increased in a greater than linear manner with WT sTnC, and suggests that Ca(2+) binding to each functional Tn activates < 7 actins of a structural regulatory unit in cardiac muscle and > 7 actins in skeletal muscle. The Ca(2+) sensitivity of force and rate of force redevelopment (k(tr)) was leftward shifted by 0.1-0.2 -log [Ca(2+)] (pCa) units as WT cTn content was increased, but the slope of the force-pCa relation and maximal k(tr) were unaffected by loss of near-neighbour RU interactions. Cross-bridge inhibition (with butanedione monoxime) or augmentation (with 2 deoxy-ATP) had no greater effect in cardiac muscle with disruption of near-neighbour RU interactions, in contrast to skeletal muscle fibres where the effect was enhanced. The rate of Ca(2+) dissociation was found to be > 2-fold faster from whole cardiac Tn compared with skeletal Tn. Together the data suggest that in cardiac (as opposed to skeletal) muscle, Ca(2+) binding to individual Tn complexes is insufficient to completely activate their corresponding RUs, making thin filament activation level more dependent on concomitant Ca(2+) binding at neighbouring Tn sites and/or crossbridge feedback effects on Ca(2+) binding affinity.