gebhart/patrepeval huggingface dataset:
Detection of oxygen using short external cavity GaAs semiconductor diode lasers (1990)

High sensitivity detection of O(2) in the near infrared with short external cavity (SXC) AlGaAs semiconductor diode lasers is reported. The mode control provided by the SXC enhances the performance of these diode lasers by allowing a number of single laser modes (up to ten) to be individually selected and continuously scanned over extended frequency intervals. At a constant laser heat sink temperature, this provides nearly complete spectral coverage of up to approximately 40 cm(-1) for overlapping modes. When using second harmonic detection techniques, these SXC controlled lasers were found to provide high sensitivity detection of O(2) at atmospheric pressure. A minimum detectable absorbance of approximately 4 x 10(-6) has been achieved with a SNR of 1. The stability of these laser systems has also allowed the continuous monitoring of an absorption signal over extended time intervals. Absorbances of 1 x 10(-2) have been continuously monitored for durations of up to 15 h with an rms uncertainty of +/-6 x 10(-5). These results are reproducible for measurements made on all the laser modes that could be selected with the SXC.
Determination of amorphous phase levels in Portland cement clinker (2002)

The existence of glass or amorphous component in Portland cement clinker has been questioned for a long time. However, besides the crystalline phases, there are reports in the literature of noncrystalline material in cement clinker, which is considered to be the residue of the melt that has failed to crystallize. Absolute phase abundances were determined in this study by Rietveld refinements with laboratory X-ray data, using both internal and external phase composition standards. The results clearly demonstrate the existence of an amorphous component in Portland cement clinker. The presence of an amorphous component was also apparent from diffraction data for clinker from which the silicate phases had been chemically removed, using both laboratory X-ray and synchrotron radiation patterns.
A Rapid Method for in Vitro Screening of Immunosuppressants Using Mouse Spleen Cells (1970)

An in vitro system for quantitatively measuring hemolysin production by mouse spleen cells is described. The synthesis of hemolysin was shown to be de novo and the rate of appearance was linear with respect to culture time. Known immunosuppressive chemicals were tested using this system and were found to be effective at inhibiting antibody production whereas nonimmunosuppressive drugs were noneffective. These findings suggested that this system would be suitable for rapidly screening chemicals for immunosuppressive activity and may be of aid in determining their mode of action at a cellular level.
Speeding up liquid crystal SLMs using overdrive with phase change reduction (2013)

Nematic liquid crystal spatial light modulators (SLMs) with fast switching times and high diffraction efficiency are important to various applications ranging from optical beam steering and adaptive optics to optical tweezers. Here we demonstrate the great benefits that can be derived in terms of speed enhancement without loss of diffraction efficiency from two mutually compatible approaches. The first technique involves the idea of overdrive, that is the calculation of intermediate patterns to speed up the transition to the target phase pattern. The second concerns optimization of the target pattern to reduce the required phase change applied to each pixel, which in addition leads to a substantial reduction of variations in the intensity of the diffracted light during the transition. When these methods are applied together, we observe transition times for the diffracted light fields of about 1 ms, which represents up to a tenfold improvement over current approaches. We experimentally demonstrate the improvements of the approach for applications such as holographic image projection, beam steering and switching, and real-time control loops.
Design and evaluation of tapped inductors for high-voltage auxiliary power supplies for modular multilevel converters (2012)

Tapped-inductor buck converters can provide large step-down ratios at high efficiency and are well suited in auxiliary power supplies for modular multilevel converter cells supplying gate drive units etc. In this paper the design and testing of three low-leakage tapped inductors for use in a 3kV, 100W buck converter is described.
Computing Minimum Area Homologies (2014)

Abstract Calculating and categorizing the similarity of curves is a fundamental problem which has generated much recent interest. However, to date there are no implementations of these algorithms for curves on surfaces with provable guarantees on the quality of the measure. In this paper, we present a similarity measure for any two cycles that are homologous, where we calculate the minimum area of any homology (or connected bounding chain) between the two cycles. The minimum area homology exists for broader classes of cycles than previous measures which are based on homotopy. It is also much easier to compute than previously defined measures, yielding an efficient implementation that is based on linear algebra tools. We demonstrate our algorithm on a range of inputs, showing examples which highlight the feasibility of this similarity measure.
Developing a File System Structure to Solve Healthy Big Data Storage and Archiving Problems Using a Distributed File System (2018)

Recently, the use of internet has become widespread, increasing the use of mobile phones, tablets, computers, Internet of Things (IoT) devices and other digital sources. In the health sector with the help of new generation digital medical equipment, this digital world also has tended to grow in an unpredictable way in that it has nearly 10% of the global wide data itself and continues to keep grow beyond what the other sectors have. This progress has greatly enlarged the amount of produced data which cannot be resolved with conventional methods. In this work, an efficient model for the storage of medical images using a distributed file system structure has been developed. With this work, a robust, available, scalable, and serverless solution structure has been produced, especially for storing large amounts of data in the medical field. Furthermore, the security level of the system is extreme by use of static Internet protocol (IP), user credentials, and synchronously encrypted file contents. One of the most important key features of the system is high performance and easy scalability. In this way, the system can work with fewer hardware elements and be more robust than others that use name node architecture. According to the test results, it is seen that the performance of the designed system is better than 97% from a Not Only Structured Query Language (NoSQL) system, 80% from a relational database management system (RDBMS), and 74% from an operating system (OS).
Female Genital Mutilation: Health Consequences and Complications—A Short Literature Review (2018)

Female genital mutilation (FGM) is a procedure performed on women in developing countries and is underreported; it involves cutting or altering the female genitalia. The health consequences of FGM include bacterial and viral infections, obstetrical complications, and psychological problems. In this study, we report FGM societal importance, ramifications, classifications, cultural significance, prevalence, complications, implications, and treatment. Although efforts have been made to eradicate FGM, the dynamics that perpetuate the practice have societal roots. Intervention methods to promote change from within the community are necessary for successful eradication of the practice. For prevention, further studies are needed to develop programs that raise awareness.
Heterocyclic compounds from urea derivatives. Part X. Addition products of isocyanate esters and diaminoguanidine or its hydrazones, and their cyclisation (1966)

The condensation of NN′-di(isopropylideneamino)guanidine and aryl isocyanates yields 1-(substituted)-anilinoformyl-2,3-di(isopropylideneamino)guanidines, which are smoothly cyclised in acid media, with loss of arylamine, to 3-hydrazino-5-hydroxy-1,2,4-triazole. The formulation of this triazole is based on its mode of formation, which is parallel to that of its 5-mercapto-analogue of established structure; it is supported by its chemical behaviour, particularly its degradation to authentic 3-hydroxy-1,2,4-triazole. NN′-Diaminoguanidine reacts additively with one or two moles of isocyanate, to give N-amino-N′-(ω-arylureido)- or NN′-di-(ω-arylureido)-guanidines, respectively, which are isolated as suitable salts. The former, retaining a hydrazino-group in their structure, are capable of yielding derivatives with ketones and β-diketones as expected.
Fraunhofer line optical correlator for improvement of initial orbit determination (2017)

The design of a Fraunhofer line optical correlator is detailed. The instrument described herein correlates a reflected solar spectrum against multiple Fraunhofer absorption lines to estimate the radial velocity of the reflecting body. By using a spatial light modulator (SLM) as a photomask for known solar absorption lines in the visible spectrum, the ratio of Doppler shifted solar energy to the total received energy can be calculated. Although the reflected light from targets in high orbit is weak, signal-to-noise ratio (SNR) is enhanced by the measurement of multiple Fraunhofer lines in a single snapshot image. Simulations indicate that prediction of orbital parameters is improved by incorporation of this velocity information, and in some cases the number of line-of-sight measurements can be reduced from three to two.
Arterial pulsatility improvement in a feedback-controlled continuous flow left ventricular assist device: An ex-vivo experimental study (2014)

Continuous flow left ventricular assist devices (CF-LVADs) reduce arterial pulsatility, which may cause long-term complications in the cardiovascular system. The aim of this study is to improve the pulsatility by driving a CF-LVAD at a varying speed, synchronous with the cardiac cycle in an ex-vivo experiment. A Micromed DeBakey pump was used as CF-LVAD. The heart was paced at 140 bpm to obtain a constant cardiac cycle for each heartbeat. First, the CF-LVAD was operated at a constant speed. At varying-speed CF-LVAD assistance, the pump was driven such that the same mean pump output was generated. For synchronization purposes, an algorithm was developed to trigger the CF-LVAD each heartbeat. The pump flow rate was selected as the control variable and a reference model was used for regulating the CF-LVAD speed. Continuous and varying-speed CF-LVAD assistance provided the same mean arterial pressure and flow rate, while the index of pulsatility doubled in both arterial pressure and pump flow rate signals under pulsatile pump speed support. This study shows the possibility of improving the pulsatility in CF-LVAD support by regulating pump speed over a cardiac cycle without compromising the overall level of support.
Iron Nitride Family at Reduced Dimensions: A Review of Their Synthesis Protocols and Structural and Magnetic Properties (2014)

Magnetic nanoparticles (NPs) are prominent in various fields of scientific research and applications such as magnetic energy storage, magnetic fluids, biomedical fields, and catalysis. Metallic Fe NPs are difficult to protect from air oxidation, and iron oxide NPs suffer from reduced magnetization. Iron nitrides have the advantage of retaining high saturation magnetization (MS); for example, α″-Fe16N2 and γ′-Fe4N have average magnetic moments of 2.9 and 2 μB/Fe, respectively, which are comparable to 2.2 μB/Fe for α-Fe. The iron nitrides are ferromagnetic (FM) up to a maximum lattice dilution of 25% nitrogen for ε-Fe3N. Even though Fe–N NPs are extremely attractive as magnetic materials, the focus has been majorly on the bulk powders and thin films. This review provides a comprehensive overview of the crystal structures, nitriding kinetics, and synthesis methodologies of binary, doped, and ternary nanostructures, thin films, and bulk materials and their magnetism. Substitution of Fe by any other metal atom in the doped and ternary nanostructures breaks the long-range FM ordering but equally provides interesting low-temperature magnetic ordering such as spin glass and exchange bias. The dopant concentration dependence of the magnetic properties of the hybrid systems is discussed.
Development of an immunoassay specific for the PSA-ACT complex without the problem of high background (1998)

We have developed an assay specific for the PSA-ACT (PSA-alpha 1-antichymotrypsin) complex that effectively diminishes the problem of high assay background commonly reported by other investigators. The assay follows a two-site ELISA format. Polyclonal anti-PSA antibodies were coated on the microplate to capture the PSA complex from the serum, whereas the biotinylated anti-ACT polyclonal antibodies and HRP-conjugated streptavidin were used for detection. The high background ordinarily associated with this assay was greatly reduced when milk casein was added in addition to albumin for blocking and when the Super Block was also included in the diluents for sample dilution and dilution of enzyme conjugated detecting antibodies. The assay has a sensitivity of 0.05 ng/mL. The within-run precision ranges from 4.2-7.2% and the between-run precision falls between 5.8-8.5%. Cross reactions with ACT and free PSA (fPSA) are 0.0001% and 0.02%, respectively. The highest concentration of PSA-ACT complex in the maternal sera was < 0.4 ng/mL by this assay, much less than reported in the literature. Using this improved assay, the sum of fPSA and PSA-ACT concentrations were less than that of their corresponding total PSA (tPSA) most of the time. We believe that this improved assay should be used to replace the current tPSA assay for screening, monitoring, and managing patients with prostate cancer.
Transmucosal Delivery of Oxytocin to Rabbits Using a Mucoadhesive Buccal Patch (1997)

A biocompatible, mucoadhesive buccal patch was evaluated in rabbits for transmucosal delivery of peptides. Oxytocin (OT) was incorporated into custom coformulations of Carbopol 974P and silicone polymer and the resulting plasma OT concentration versus time profiles determined following patch application. For comparative purposes, the mean values determined for the elimination half-life (t1/2), volume of distribution (Vd), and the total body clearance (CL) following intravenous injection of OT were 2.9 +/- 0.2 min, 85.3 +/- 6.7 ml, and 20.4 +/- 2.03 ml/min, respectively. Following application of oxytocin-loaded mucoadhesive patches, plasma OT concentrations remained 20- to 28-fold greater from 0.5 to 3.0 hr than control animals administered placebo patches. The steady-state plasma OT concentration (Css) following application of the buccal patches was 80.6 +/- 15.9 pg/ml. The lag-time associated with attainment of the Css was 0.45 +/- 0.18 hr. Steady-state flux (Jss) of oxytocin in vivo was 139 +/- 36.8 ng/hr/cm2. Based on the amount of OT remaining in the patches following removal, the average dose of OT released in vivo was 0.27 +/- 0.024 mg with a bioavailability of 0.1%. No significant alterations in mucosal histology were observed when underlying mucosa to which OT patches had been applied were compared to either control (no patch) mucosa or mucosa underneath placebo patches. The mucoadhesive buccal patches were easy to apply and remove, nonirritating to tissue, and able to continuously deliver a nonapeptide over 3 hr. Based on these preliminary studies, the mucoadhesive buccal patches evaluated may represent an improved transmucosal drug delivery system for peptides and conventional drug substances.
Tonic Serotonin Measurements<i>In Vivo</i>Using N-Shaped Multiple Cyclic Square Wave Voltammetry (2021)

Here, we present the development of a novel voltammetric technique, N-shaped multiple cyclic square wave voltammetry (N-MCSWV) and its application <i>in vivo</i>. It allows quantitative measurements of tonic extracellular levels of serotonin <i>in vivo</i> with mitigated fouling effects. N-MCSWV enriches the electrochemical information by generating high dimensional voltammograms, which enables high sensitivity and selectivity against 5-hydroindoleacetic acid (5-HIAA), dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), histamine, ascorbic acid, norepinephrine, adenosine, and pH. Using N-MCSWV, in combination with PEDOT:Nafion-coated carbon fiber microelectrodes, a tonic serotonin concentration of 52 ± 5.8 nM (<i>n</i> = 20 rats, ±SEM) was determined in the substantia nigra pars reticulata of urethane-anesthetized rats. Pharmacological challenges with dopaminergic, noradrenergic, and serotonergic synaptic reuptake inhibitors supported the ability of N-MCSWV to selectively detect tonic serotonin levels <i>in vivo</i>. Overall, N-MCSWV is a novel voltammetric technique for analytical quantification of serotonin. It offers continuous monitoring of changes in tonic serotonin concentrations in the brain to further our understanding of the role of serotonin in normal behaviors and psychiatric disorders.
<title>Cerium-containing counter electrodes for transparent electrochromic devices</title> (1997)

Films of Me-Ce oxide (Me: Ti, Zr, Sn, W) and of Ni-Ce hydroxide were produced by reactive magnetron co-sputtering. Li intercalation in Me-Ce oxide, and H exchange in Ni-Ce hydroxide, were accomplished electrochemically. Electrochromism was quenched in proportion with the Ce content in Me-Ce oxide. Films of Zr-Ce (and to some extent Ti-Ce) oxide were able to serve as fully transparent counter electrodes, of much interest for transparent electrochromic devices. In Ni-Ce hydroxide, the Ce addition enhanced the capacity for charge exchange.
Species Differences in the Metabolism and Disposition of Antiviral Nucleoside Analogues: 1. Acyclovir (1992)

The acyclic nucleoside analogue, acyclovir, is an antiviral drug with activity against the herpes group of DNA viruses. Clinically, it is used as a selective therapeutic agent for the treatment of herpes simplex and varicella-zoster virus infections. Studies on the disposition of acyclovir, during the course of its preclinical and clinical development, indicated significant species differences in the absorption, metabolism and elimination of the drug. Gastrointestinal absorption was adequate in dogs and in mice; but in rats and primates it was limited to less than 20% of the administered dose. Whereas in some species (mice, rats, and dogs), acyclovir was virtually unmetabolized, significant biotransformation was apparent in guinea pigs, rabbits, and some primates. Acyclovir tissue distribution was extensive and indicated few differences across species. This review summarizes diverse studies on acyclovir absorption, metabolism, and disposition in different species, including humans, and indicates the relevance and importance of such studies in drug development.
Molecular approaches to the control of infectious diseases (1995)

Immunity and viruses DNA immunization I DNA immunization 2 bacterial vaccines recombinant antibodies mucosal immunity and delivery systems SIV parasite vaccines HIV the Albert B. Sabin lecture.
The suppressive effect of anti-asialo GM1 antibody on low-dose streptozotocin-induced diabetes in CD-1 mice. (1991)

To elucidate the role of natural killer (NK) cells in the pathogenesis of diabetes in streptozotocin-induced diabetes, we examined whether treatment with anti-asialo GM1 antibody prevents the occurrence of diabetes in CD-1 mouse model. Anti-asialo GM1 antibody was injected intraperitoneally 2-3 times a week starting three days before the first streptozotocin injection. In controls, rabbit immunoglobulin or saline was injected instead of anti-asialo GM1 antibody. Three of twelve anti-asialo GM1 antibody-treated mice developed diabetes, however eight of eight (100%) rabbit immunoglobulin injected mice and 20 of 23 saline-injected mice developed diabetes. The incidence of diabetes in the anti-asialo GM1 antibody-injected group was significantly higher than in the two control groups (p less than 0.01, p less than 0.01, respectively). The NK-cell activities of spleen cells from anti-asialo GM1 antibody-treated mice were significantly lower than in control mice. Flow-cytometry analysis demonstrated that anti-asialo GM1 antibody-positive cells had disappeared from spleens of anti-asialo GM1 antibody-injected mice but no suppression of T-lymphocytes could be demonstrated. These results suggest that NK cells play a role in the pathogenesis of streptozotocin-induced diabetes in CD-1 mice.
Implementation of the CAN-FD protocol in the fuzzing tool beSTORM (2016)

With the growth of ECUs that are mounted in automobiles, the transmission capacity of Controller Area Network (CAN), which is currently used by most on-vehicle networks, is becoming insufficient, and therefore CAN With Flexible Data Rate (CAN-FD), presented by Bosch GmbH, is viewed as a nextgeneration standard. Recently, the number of attacks on ECUs connected to CAN has been increasing, and from the viewpoint of CAN security there has been much discussion of safety. However, with regard to CAN-FD, which is an expansion of CAN, although a discussion of safety is needed, that has hardly happened. This paper reports on an implementation that uses the generic fuzzing tool beSTORM to investigate the vulnerability of the CAN-FD protocol. We also aim at practical application by measuring the transmission time for beSTORM test data and by estimating the time required for CAN-FD fuzzing tests.
A Vibrating-Plate Viscometer (1953)

When a thin, flat plate executing linear oscillations in its own plane is immersed in a liquid, shear waves are set up in the liquid, and the liquid exerts a retarding force on the plate. This force, which can be measured by means of an electromechanical transducer to which the vibrating plate is coupled, is a function of the product ηρ of the coefficient of viscosity and the density of the liquid. Electrical measurements thus permit a computation of the value of ηρ. A viscometer which operates on this principle and is simple in both construction and use is described. This instrument gives instantaneous indications of ηρ over a wide range and also permits continuous indications of ηρ as a function of time to be made. A theory based on the impedance offered to an infinite vibrating plate by a liquid in which it is immersed is shown experimentally to give a valid, approximate description of the performance of the vibrating-plate viscometer in its practical form.
Case study : Lahore, Pakistan - conservation of the walled city (1999)

Pakistan's Lahore is a jewel in Pakistan's heritage. The technological, cultural, and population changes in Lahore are not compatible with the planning, form, and ancient structures of the Walled City. The central government and the local administrations are aware of the importance of integrating conservation in development planning and urban upgrading procedures. In this context the Bank and the Punjab Government initiated the Punjab Urban Development Project (Credit 1895). One of the project components in Lahore is the conservation of the Walled City. The paper proposes a framework for developing a universally accepted strategy for the integration of conservation with development planning drawing upon the lessons learned from the experience in the Walled City of Lahore, and making comparisons with similar projects in other urban areas of the world. The paper examines: a) background theory for such integration and the need for conservation, the principles of such policy and the administrative requirements for implementation of the project in detail; b) conservation initiatives in the rest of Pakistan and their importance with particular emphasis on the implications of laws and their applications, which in the case of conservation policy is more communal; and c) the details of the experiences and conclusions of the projects undertaken in Lahore.