gebhart/patrepeval huggingface dataset:
Sub-array normalization subject to differentiation (2005)

From microarray measurement, we seek differentiation of mRNA expressions among different biological samples. However, each array has a 'block effect' due to uncontrolled variation. The statistical treatment of reducing the block effect is usually referred to as normalization. Our perspective is to find a transformation that matches the distributions of hybridization levels of those probes corresponding to undifferentiated genes between arrays. We address two important issues. First, array-specific spatial patterns exist due to uneven hybridization and measurement process. Second, in some cases a substantially large portion of genes are differentially expressed between a target and a reference array. For the purpose of normalization we need to identify a subset that exclude those probes corresponding to differentially expressed genes and abnormal probes due to experimental variation. Least trimmed squares (LTS) is a natural choice to achieve this goal. Substantial differentiation is protected in LTS by setting an appropriate trimming fraction. To take into account any spatial pattern of hybridization, we divide each array into sub-arrays and normalize probe intensities within each sub-array. We illustrate the problem and solution through an Affymetrix spike-in dataset with defined perturbation and a dataset of primate brain expression.
Testing of Vega2, a chip multi-processor with spare processors. (2007)

Vega2 is a CMP (chip multi-processor) with 48 processor cores, and several spare cores to improve yield. The chip also contains about 1000 memory macros both inside and outside the processor cores. The larger memories have column redundancy as well. The main DFT challenge for Vega2 is to produce an architecture that makes it easy to identify defective processors, thoroughly test the memories and efficiently apply ATPG patterns.
Stereospecific Ester Activation in Nitrite-Mediated Carbohydrate Epimerization (2006)

[reaction: see text] The Lattrell-Dax method of nitrite-mediated substitution of carbohydrate triflates is an efficient method to generate structures of inverse configuration. In the present study, epimerization of gluco- and galactopyranoside derivatives to the corresponding allo- and gulopyranoside structures by triflation/nitrite treatment has been investigated. It was found that a neighboring ester group was essential for the reactivity of the nitrite-mediated triflate inversion. Furthermore, a good inversion yield also depended on the relative configuration of the neighboring ester group to the triflate. Only with the ester group in the equatorial position, whatever the configuration of the triflate, did the reaction proceed smoothly, whereas a neighboring axial ester group proved largely inefficient. The results were subsequently used to predict the inversion of glucopyranoside derivatives to the mannopyranoside epimers.
Lifecycle analysis for environmentally conscious solid freeform manufacturing (2002)

A lifecycle based process model for analyzing the environmental performance of SFM processes and SFM based rapid tooling processes is presented in this paper. The process environmental performance assessment model considers material, energy and disposal scenarios. The material use, process parameters (e.g. scanning speed) and power use can affect the environmental consequence of a process when material resource, energy, human health and environmental damage are taken into account. The presented method is applied to the SLA process and two SLA based rapid tooling processes. The method can be used to compare different rapid prototyping (RP) and RT processes in terms of their environmental friendliness and for further multi-objective decision making.
Catalytic Cyclophanes. Part XI. A flavo‐thiazolio‐cyclophane as a biomimetic catalyst for the preparative‐scale electro‐oxidation of aromatic aldehydes to methyl esters (1997)

Abstract Flavo‐thiazolio‐cyclophane 6 was prepared on a gram scale by an 18‐step synthesis ( Schemes 3 and 4 ). This pathway involved the very efficient preparation of bromo‐cyclophane 32 (37% yield over 13‐steps), which can be readily modified to create various multiply functionalized receptors. This bromide 32 was subsequently converted into the corresponding boronic acid and connected to the 7‐bromoflavin 10 ( Scheme 2 ) via Suzuki coupling to give flavo‐cyclophane 36 . The thiazolium unit was then introduced after quaternization of the tertiary amino groups of 36 . Flavo‐thiazolio‐cyclophane 6 , with both prosthetic groups attached in proximity to the well‐defined cyclophane binding site, is a functional model for the enzyme pyruvate oxidase. In basic methanolic solution, 6 catalyzes the oxidation of aromatic aldehydes to their corresponding methyl esters. Cyclophane 6 shows saturation kinetics, and the turnover number calculated for the oxidation of naphthalene‐2‐carbaldehyde to methyl naphthalene‐2‐carboxylate ( k cat = 0.22 s −1 ) is one of the highest reported for an artificial enzyme. Control experiments showed that the catalytic advantages of 6 result from the macrocyclic binding and reaction site as well as from the covalent attachment of both cofactors to this site. The catalytic cycle is completed by electrochemical re‐oxidation of the reduced flavin moiety at a low working electrode potential (‐ 0.3 V vs. Ag/AgCl), and up to ca. 100 catalytic cycles can be performed on a preparative scale, The intramolecular nature of the electron transfer from the active aldehyde intermediate to the flavin is particularly conducive to the oxidation of unreactive aldehydes.
Speaker recognition using G.729 speech codec parameters (2002)

Experiments in Gaussian-mixture-model speaker recognition from mel-cepstra, derived from mel-filter bank energies (MFBs) of the G.729 codec all-pole spectral envelope, showed significant performance loss relative to the standard mel-cepstral coefficients of G.729 synthesized (coded) speech (Quatieri et al. 1999). In this paper, we investigate two approaches to recover speaker recognition performance from G.729 parameters. The first is a parametric approach that makes explicit use of G.729 parameters, rather than deriving cepstra from MFBs of an all-pole spectrum. Specifically, the G.729 LSFs are converted to "direct" cepstral coefficients for which there exists a one-to-one correspondence with the LSFs. The G.729 residual is also considered; in particular, appending G.729 pitch as a single parameter to the direct cepstral coefficients gives further performance gain. The second nonparametric approach uses the original MFB paradigm, but adds harmonic striations to the G.729 all-pole spectral envelope. Although obtaining considerable performance gains with these methods, we have yet to match the performance of G.729 synthesized speech, motivating the need for representing additional fine structure of the G.729 residual.
Non-linear inverse scattering: High resolution quantitative breast tissue tomography (2012)

Recent published results in inverse scattering generally show the difficulty in dealing with moderate to high contrast inhomogeneities when employing linearized or iteratively linearized algorithms (e.g., distorted Born iterative method). This paper presents a fully nonlinear algorithm utilizing full wave field data, that results in ultrasound computed tomographic images from a laboratory breast scanner, and shows several such unique images from volunteer subjects. The forward problem, data collection process and inverse scattering algorithm used are discussed. A functional that represents the "best fit" between predicted and measured data is minimized, and therefore requires a very fast forward problem solver, Jacobian calculation, and gradient estimation, all of which are described. The data collection device is described. The algorithm and device yield quantitative estimates of human breast tissue in vivo. Several high resolution images, measuring ∼150 by 150 wavelengths, obtained from the 2D inverse scattering algorithms, using data collected from a first prototype, are shown and discussed. The quantitative values are compared with previous published work.
Sensor Abnormal Detection and Recovery Using Machine Learning for IoT Sensing Systems (2019)

In sensing systems in various environments, such as environmental monitoring and smart power grid systems, sensors are usually unreliable due to improper calibration, low battery levels or hardware failures of the devices. Unreliability may cause users to make erroneous decisions or inaccurate analysis. In this paper, we propose a detect system architecture to avoid the abnormality among the sensors based on machine learning. The detection mechanism has to be in real-time by exploring the correlation among the sensors, and predicting the supplemental values via other correlated sensors. We analyze the fault data pattern in order to classify the fault type of faulty sensors and also to recover the faulty sensors for improving the reliability of sensing systems.
Translation with optimization from relational calculus to relational algebra having aggregate functions (1990)

Most of the previous translations of relational calculus to relational algebra aimed at proving that the two languages have the equivalent expressive power, thereby generating very complicated relational algebra expressions, especially when aggregate functions are introduced. This paper presents a rule-based translation method from relational calculus expressions having both aggregate functions and null values to optimized relational algebra expressions. Thus, logical optimization is carried out through translation. The translation method comprises two parts: the translational of the relational calculus kernel and the translation of aggregate functions. The former uses the familiar step-wise rewriting strategy, while the latter adopts a two-phase rewriting strategy via standard aggregate expressions. Each translation proceeds by applying a heuristic rewriting rule in preference to a basic rewriting rule. After introducing SQL-type null values, their impact on the translation is thoroughly investigated, resulting in several extensions of the translation. A translation experiment with many queries shows that the proposed translation method generates optimized relational algebra expressions. It is shown that heuristic rewriting rules play an essential role in the optimization. The correctness of the present translation is also shown. Each translation proceeds by applying a heuristic rewriting rule in preference to a basic rewriting rule. After introducing SQL-type null values, their impact on the translation is thoroughly investigated, resulting in several extensions of the translation. A translation experiment with many queries shows that the proposed translation method generates optimized relational
Neighbors and relative location identification using RSSI in a dense wireless sensor network (2014)

Wireless Sensor Networks (WSNs) are made of a large amount of small devices that are able to sense changes in the environment, and communicate these changes throughout the network. An example of such network is a photo voltaic (PV) power plant, where there is a sensor connected to each solar panel. Because such a network covers a large area, the number of sensors can be very large. The task of each sensor is to sense the output of the panel which is then sent to a central node for processing. As the network grows, it becomes impractical and even impossible to configure all these nodes manually. And so, the use of self-organization and auto-configuration algorithms becomes essential. In this paper, two algorithms are proposed that can be used to allow each node in the network to automatically identify its closest neighbors as well as its relative location in the network using the value of the Received Signal Strength indicator (RSSI) of the messages sent back and forth during the setup phase. Results show that the error in neighbor identification decreases as we increase the number of RSSI values used for decision making. Additionally, the number of nodes in the network affects the setup error greatly. However, the value of the error is still acceptable even for high number of simulated columns.
[Passive immunotherapy with polyvalent immunoglobulins in women with habitual abortions]. (1990)

Intravenous immunoglobulins (IVIG) were used in an alternative approach to immunotherapy with allogeneic leukocytes to prevent recurrent spontaneous abortions (RSA). Twenty five women with a history of greater than or equal to 3 unexplained RSA were treated with IVIG during their next pregnancy. An initial dose of 30 g (0.5-0.6 g/kg body weight) was administered at gestational week 5-6. Treatment was continued every 3 weeks with 20 g (0.3-0.4 g/kg) and terminated by week 25. In primary RSA the success rate was 82-85%, which is in the same range as for leukocyte therapy. In contrast, IVIG was successful in only 40% of secondary aborters. We conclude that IVIG can be an effective treatment for prevention of primary RSA. Compared to leukocyte therapy the risks of transmission of infections and of HLA immunization can be avoided.
Anchoring the Consistency Dimension of Data Quality Using Ontology in Data Integration (2009)

Data quality is crucial for data integration and the consistency dimension is an important issue in data quality. Traditional methods of data consistency focus on the conflict or inconsistency that occurs in the same concept. However, it is sometimes insufficient to ensure the data consistency only using these methods. In this paper, we divide the conflicts among different data sources into the traditional intra-concept conflict and the neglected inter-concept conflict based on ontology, and then we propose a detection model for these conflicts. Ontology mapping, including concept mapping and restriction verification, is the key issue in our model. We analyze the consistency dimension of data quality using the model. Both the classification and the model help us ensure the data consistency in data integration efficiently. Data from the third party and business processes of the applications can be used to resolve the inconsistency when conflicts are detected.
Microfluidic generation of hollow Ca-alginate microfibers (2016)

This work reports on an efficient microfluidic approach for continuous production of hollow Ca-alginate microfibers with controllable structures and functions. A coaxial microcapillary microfluidic device combined with a rotator is constructed to produce a cylindrical flow jet with four aqueous solutions as templates for continuous fabrication and collection of microfibers. A four-aqueous-phase flow jet with an intermediate buffer flow between the Ca(2+)-containing and alginate-containing flows is used as the template for microfiber fabrication. The buffer flow efficiently controls the diffusion of Ca(2+) into the alginate-containing flow as well as the crosslinking reaction, thus ensuring the continuous fabrication of hollow Ca-alginate microfibers under relatively low flow rates without clogging of the microchannel. The structure of the hollow microfibers can be flexibly adjusted by changing the flow rates and device dimensions. Meanwhile, the continuous fabrication process of the microfibers allows flexible incorporation of a functional component into the sheath flow for functionalization and addition of active substances in the core flow for encapsulation. This is demonstrated by fabricating hollow Ca-alginate microfibers with a wall containing magnetic nanoparticles for magnetic functionalization and with hollow internals containing Chlorella pyrenoidosa cells for confined growth. This work provides an efficient strategy for continuous fabrication of functional hollow Ca-alginate microfibers with controllable structures and functions.
Application of nanogel systems in the administration of local anesthetics (2010)

Nanogels are robust nanoparticles that could be used to deliver active drug compounds in controlled drug delivery applications. This review discusses the design, synthesis, loading, and release of local anesthetics using polymeric nanoparticles produced via various types of polymerization techniques. The strategy of using layer-by-layer approach to control the burst release of procaine hydrochloride (PrHy; a local anesthetic drug of the amino ester group) is described and discussed.
Regression by Vitamin E of Experimental Oral Cancer (1987)

Vitamin E was shown to regress established epidermoid carcinomas of Syrian hamster buccal pouch in 20 experimental animals following tumor induction by applications three times a week of 0.5% 7,12-dimethylbenz[a]anthracene (CAS: 57-97-6) in mineral oil for 13 weeks. The vitamin E was injected into the tumor-bearing buccal pouch twice weekly for 4 weeks in a dose of 250 micrograms in minimum essential medium. Twenty animals were maintained as untreated controls, and another 20 animals were sham-inoculated vehicle controls. Microscopic examination of buccal pouches with regressed tumor showed small epidermoid carcinomas with degeneration of tumor cells and a dense infiltrate of leukocytes, lymphocytes, and histiocytes. Buccal pouches of control animals showed large well-differentiated or moderately differentiated epidermoid carcinomas. The hamster buccal pouch cancer model presents many similarities to human oral cancer, including expression of the same oncogene, and these results offer hope for the chemotherapy of human oral cancer with the use of a relatively nontoxic agent injected locally.
Effect of the hematocrit and its correction on the relationship between blood tacrolimus concentrations obtained using the microparticle enzyme immunoassay (MEIA) and enzyme multiplied immunoassay technique (EMIT). (2007)

The Abbott microparticle enzyme immunoassay (MEIA) and the Dade Behring enzyme multiplied immunoassay technique (EMIT) are the most frequently used methods in the therapeutic drug monitoring of tacrolimus; however, a hematocrit-dependent interference for the MEIA has been described. In 244 whole blood samples from patients with liver (n=152) and kidney (n=92) transplants, the MEIA/EMIT ratio presented a highly significant negative correlation with the hematocrit (r = -0.482, p < 0.001). On distributing the samples into three groups with a hematocrit of less than 30%, 30-40%, and higher than 40%, different regression equations were found between the results of MEIA and EMIT and demonstrate the different effect of the hematocrit on both immunoassays. Correcting the MEIA results by calculation for a hematocrit of less than 30% and higher than 40% (Hermida et al. Clin Lab 2005; 51: 43-45) led to a regression with EMIT that was similar to that found between MEIA and EMIT for the group of samples with a hematocrit of 30-40%. Furthermore, the corrected MEIA/EMIT ratio had a poor correlation with the hematocrit (r = 0.149, p < 0.05). In 95 samples with a hematocrit of less than 25% (n=73) and higher than 40% (n=22) we also determined the tacrolimus levels using the modified MEIA method to correct hematocrit interference, as proposed by Tomita et al. (Ther Drug Monit 2005; 27: 94-97). In the samples with a hematocrit of less than 25%, correcting the MEIA results by calculation produced results that were similar and had a high correlation coefficient (r = 0.954, p < 0.001) to those of the modified MEIA method, whose application as a routine practice is more expensive and laborious. Calculation of the corrected MEIA values in anemic patients may be useful for the therapeutic monitoring of tacrolimus.
An intelligent symbol usage assistant for CAD systems (1994)

The Augurs (Assistant for Using Graphic Symbols) program embeds a neural network for symbol recognition in a commercial CAD system (the US Army Corps of Engineers' MicroStation). The goals are to accelerate the drawing process, maintain drawing consistency, and, most importantly, attach symbolic information to graphic entities so they can be analyzed and communicated across platforms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rocket Propulsion (1935)

THOUGH rockets have aroused a good deal of public interest during the last few years and a great number of very interesting books and articles have been published about the theoretical side of this new science, little is generally known about the experimental progress that has been made, especially in Germany and the U.S.A. In describing this science—the Americans call it “rocketry”—as “new,” it is to be understood that this term applies only to the mathematics of it. The ordinary powder or “sky” rocket is by no means new, but has a long and very involved history, going back to Hassan Alrammah, called “nedshm‐eddin” (The Faithful) in A.D. 1280, who designed the first rocket‐driven torpedo. But though rockets in general ( i.e. the powder rocket, which alone existed previous to 1929) have a history of almost a millennium and have even been of historical importance (Sir William Congreve's war‐rockets), the manufacturers of powder rockets knew nothing about their mathematics. When, for example, in 1928 the German Verein für Raumschiffahrt discussed the problem of exhaust velocities and impulses, its president, Johannes Winkler, asked the largest rocket factories about this information and received the answer that they did not know it and had no way of determining it. Winkler was therefore obliged to take the thrust‐diagram of a powder rocket himself (Fig. 1). This diagram revealed that the thrust of a sky‐rocket lasts for only two‐tenths of a second; this result was really amazing and the most amazed were the manufacturers of these rockets.
Use of Lactase in the Manufacture of Dairy Products (1977)

The potential for lactase application in the manufacture of dairy products has been recognized for many years. Lactase (β-D-galactosidase) hydrolyzes milk lactose into its constituent monosaccharides, glucose and galactose. Chemical and physical changes that occur as a result of lactose hydrolysis provide the rationale for its application. The principal changes are reduced lactose content, increased carbohydrate solubility, increased sweetness, higher osmotic pressure, reduced viscosities, and more readily fermentable sugar. Enzymatic hydrolysis of lactose in dairy foods would improve product quality and provide low-lactose products for the lactose intolerant segment of the population. Available Lactases Efforts to utilize lactases for the manufacture of hydrolyzed lactose (HL) products have been restricted primarily by the lack of suitable, commercially available, enzymes. Lactases are found in plants, animals and microorganisms (Table I), but only microbial sources can be used commercially. The pH optima of the microbial lactases are quite varied. The two enzymes of
Parallelization of AMBER molecular dynamics program for the AP1000 highly parallel computer (2003)

The authors have parallelized the AMBER molecular dynamics program for the AP1000 highly parallel computer. To obtain a high degree of parallelism and an even load balance between processors for model problems of protein and water molecules, protein amino acid residues and water molecules are distributed to processors randomly. Global interprocessor communication required by this data mapping is efficiently done using the AP1000 broadcast network, to broadcast atom coordinate data for other processors' reference and its torus network; also for point-to-point communication to accumulate forces for atoms assigned to other processors. Experiments showed that a problem with 41095 atoms is processed 226 times faster with a 512 processor AP1000 than by a single processor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ChemInform Abstract: Preparation and Crystal Structure of a Stable and Persistent Twisted Tetraketene. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.