gebhart/patrepeval huggingface dataset:
Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis (2015)

In the PLATO study, ticagrelor was associated with fewer pulmonary infections and subsequent deaths than clopidogrel. Neutrophils are a first-line defence against bacterial lung infection; ticagrelor inhibits cellular uptake of adenosine, a known regulator of neutrophil chemotaxis and phagocytosis. We assessed whether the inhibition of adenosine uptake by ticagrelor influences neutrophil chemotaxis and phagocytosis. Neutrophils and erythrocytes were isolated from healthy volunteers. Concentration-dependent effects of adenosine on IL-8-induced neutrophil chemotaxis were investigated and the involved receptors identified using adenosine receptor antagonists. The modulatory effects of ticagrelor on adenosine-mediated changes in neutrophil chemotaxis and phagocytosis of Streptococcus pneumoniae were determined in the presence of erythrocytes to replicate physiological conditions of cellular adenosine uptake. Low-concentration adenosine (10(-8)M) significantly increased IL-8-induced neutrophil chemotaxis (% neutrophil chemotaxis: adenosine 28.7%±4.4 vs. control 22.6%±2.4; p<0.01) by acting on the high-affinity A1 receptor. Erythrocytes attenuated the effect of adenosine, although this was preserved by ticagrelor and dipyridamole (another inhibitor of adenosine uptake) but not by control or by cangrelor. Similarly, in the presence of erythrocytes, a low concentration of adenosine (10(-8)M) significantly increased neutrophil phagocytic index compared to control when ticagrelor was present (37.6±6.6 vs. 28.0±6.6; p=0.028) but had no effect in the absence of ticagrelor. We therefore conclude that the inhibition of cellular adenosine reuptake by ticagrelor potentiates the effects of a nanomolar concentration of adenosine on neutrophil chemotaxis and phagocytosis. This represents a potential mechanism by which ticagrelor could influence host defence against bacterial lung infection.
Method and apparatus for acoustic scanning using bulk wave scattering of bulk waves by an acoustic grating (1982)

First Page
Fluorescent latex microspheres for retrograde tracing of neurons in mouse basal forebrain combined with immunocytochemistry: a methodical approach. (1992)

The presented methodical contribution demonstrates the suitability of rhodamine-labelled latex microspheres with a defined mean diameter of around 20 nm for retrograde neuronal tracing. After small injections of about 200 nl red fluorescent tracer into visual cortex of mice afferent neurons were labelled in cortical and subcortical structures. Basal forebrain neurons containing the tracer were further characterized by the concurrent visualization of choline acetyltransferase, a marker for cholinergic neurons, and parvalbumin, a putative marker of GABAergic neurons, by immunofluorescence.
Bandwidth measurement using performance counters for predictable multicore software (2012)

Memory contention is one of the largest sources of inter-core interference in statically partitioned multicore systems, and the contention reduces the overall performance of applications and causes unpredictable execution-times. A first step in achieving predictable execution is to accurately measure the amount of consumed memory bandwidth for each application. Such measurements can be used to track down bottlenecks, provide better partitioning among cores, and ultimately be used to arbitrate and police access to the memory bus. We propose to use hardware performance counters to continuously track the memory-bandwidth consumed by different applications executing in parallel. In this paper we describe ongoing efforts exploring suitable performance counters on core-level and on system-on-chip level for the 8-core Freescale P4080 processor. The aim is to accurately and efficiently track consumed memory bandwidth per application; with the final goal to use these measurements to improve predictability of multicore realtime software.
Biosynthesis of Dermatan Sulfate (2006)

We identified the gene encoding chondroitin-glucuronate C5-epimerase (EC 5.1.3.19) that converts D-glucuronic acid to L-iduronic acid residues in dermatan sulfate biosynthesis. The enzyme was solubilized from bovine spleen, and an approximately 43,000-fold purified preparation containing a major 89-kDa candidate component was subjected to mass spectrometry analysis of tryptic peptides. SART2 (squamous cell carcinoma antigen recognized by T cell 2), a protein with unknown function highly expressed in cancer cells and tissues, was identified by 18 peptides covering 26% of the sequence. Transient expression of cDNA resulted in a 22-fold increase in epimerase activity in 293HEK cell lysate. Moreover, overexpressing cells produced dermatan sulfate chains with 20% of iduronic acid-containing disaccharide units, as compared with 5% for mock-transfected cells. The iduronic acid residues were preferentially clustered in blocks, as in naturally occurring dermatan sulfate. Given the discovered identity, we propose to rename SART2 (Nakao, M., Shichijo, S., Imaizumi, T., Inoue, Y., Matsunaga, K., Yamada, A., Kikuchi, M., Tsuda, N., Ohta, K., Takamori, S., Yamana, H., Fujita, H., and Itoh, K. (2000) J. Immunol. 164, 2565-2574) with a functional designation, chondroitin-glucuronate C5-epimerase (or DS epimerase). DS epimerase activity is ubiquitously present in normal tissues, although with marked quantitative differences. It is highly homologous to part of the NCAG1 protein, encoded by the C18orf4 gene, genetically linked to bipolar disorder. NCAG1 also contains a putative chondroitin sulfate sulfotransferase domain and thus may be involved in dermatan sulfate biosynthesis. The functional relation between dermatan sulfate and cancer is unknown but may involve known iduronic acid-dependent interactions with growth factors, selectins, cytokines, or coagulation inhibitors.
A user-centric m-payment solution (2005)

In this paper, we present a user-centric m-payment solution over Internet. The main contribution of the proposed solution includes: 1: ensuring fair-exchange; 2: ensuring the user's anonymity and privacy protection; 3: implementing an embedded biometric authentication framework for high security requirement. (8 pages)
Pregnancy Ameliorates Induction and Expression of Experimental Autoimmune Uveitis (1999)

Female patients suffering from autoimmune uveitis are reported to experience a temporary remission during pregnancy. Experimental autoimmune uveitis (EAU) is a model for human uveitis. Here we examine the effect of pregnancy on the development of EAU and its associated immunological responses. Susceptible C57BL/6 mice were immunized with interphotoreceptor retinoid-binding protein (IRBP). EAU scores and Ag-specific responses were evaluated 21 days later. Mice immunized during pregnancy developed significantly less EAU than nonpregnant controls. Their lymph node cells and splenocytes produced a distinct pattern of cytokines in response to IRBP: reduced IFN-gamma and IL-12 p40, but unchanged levels of TNF-alpha, IL-4, IL-5, and IL-10. Anti-IRBP Ab isotypes revealed an up-regulation of IgG1, indicating a possible Th2 bias at the humoral level. Ag-specific proliferation and delayed hypersensitivity, as well as mitogen-induced IFN-gamma production, remained undiminished, arguing against an overall immune deficit. Interestingly, pregnant mice that received an infusion of IRBP-primed lymphoid cells from nonpregnant donors also developed reduced EAU, suggesting that pregnancy suppresses not only the generation, but also the function of mature uveitogenic effector T cells. Pregnant mice at the time of immunization exhibited elevated levels of TGF-beta, but not of IL-10, in the serum. We suggest that protection from EAU during pregnancy is due primarily to a selective reduction of Ag-specific Th1 responses with only marginal enhancement of Th2 function, and that these effects may in part be secondary to elevated systemic levels of TGF-beta.
Instance Map Based Image Synthesis With a Denoising Generative Adversarial Network (2018)

Semantic layout-based image synthesizing, which has benefited from the success of generative adversarial networks (GANs), has received a substantial amount of attention recently. How to enhance the synthesis image equality while maintaining the stochasticity of the GAN remains a challenge. We propose a novel denoising framework to handle this problem. The generation of overlapping objects is another challenging task when synthesizing images from a semantic layout to a realistic RGB photograph. To overcome this deficiency, we include a one-hot semantic label map to force the generator to pay more attention to the generation of overlapping objects. Furthermore, we improve the loss function of the discriminator by considering the perturbed loss and cascade layer loss to guide the generation process. We applied our methods to the Cityscapes, photo-sketch, day-night, facades, and NYU datasets to demonstrate the image generation ability of our model.
Helper agent (2000)

This paper introduces a new application area for agents in the computer interface: the support of human-human interaction. We discuss an interface agent prototype that is designed to support human-human communication in virtual environments. The prototype interacts with users strategically during conversation, spending most of its time listening. The prototype mimics a party host, trying to find a safe common topic for guests whose conversation has lagged. We performed an experimental evaluation of the prototype's ability to assist in cross-cultural conversations. We designed the prototype to introduce safe or unsafe topics to conversation pairs, through a series of questions and suggestions. The agent made positive contributions to participants' experience of the conversation, influenced their perception of each other and of each others' national group, and even seemed to effect their style of behavior. We discuss the implications of our research for the design of social agents to support human-human interaction.
Synthesis of UV‐curable liquid crystalline diacrylates for the application of polarized electroluminescence (2006)

Abstract Two series of UV‐curable rod‐like diacrylates containing bis‐tolane (M1–M5) and bis‐stilbene (M6–M10) mesogens were synthesized. All of the diacrylates were prepared through convergent syntheses involving palladium‐catalysed coupling reactions. The thermal transitions and mesomorphic properties of the diacrylates were characterized by differential scanning calorimetry and optical microscopy. All the bis‐tolane‐based monomers reveal nematic phases, except M5 which shows no mesomorphic behaviour. For the bis‐stilbene based monomers, most show no mesomorphic behavior and only M7 and M9 exhibit a SmA phase. Acknowledgment The authors are grateful to the National Science Council of the Republic of China for financial support of this work. (NSC‐92‐2216‐E009‐015)
Characterization of a tick isolate of Borrelia burgdorferi that possesses a major low-molecular-weight surface protein (1990)

An unusual strain of Borrelia burgdorferi (DN 127 cl 9-2) that was isolated from an Ixodes pacificus tick did not react with monoclonal antibodies (MAbs) to OspA and OspB surface proteins, which are found in most U.S. strains. The strain exhibited an abundant protein with an apparent molecular weight of 25,000 (25K protein). A MAb, 86 DN-1, that was prepared to the 25K protein was used in studies on the effect of proteases on the intact spirochetes, immune electron microscopy, and Western blot (immunoblot) analyses; the results indicated that the low-molecular-weight protein was an apparent surface protein that was loosely attached to the spirochete. Five tick isolates from California possessed low-molecular-weight proteins in the 20,000- to 25,000-molecular-weight range that reacted with the 86 DN-1 MAb. The 25K protein of DN 127 cl 9-2 was unaffected by prolonged in vitro passage of cultures in BSK II medium, while the low-molecular-weight proteins of the other strains of B. burgdorferi from California either decreased in quantity or became undetectable on long-term in vitro passage.
B- and T-cell prolymphocytic leukemia: antibody approaches (2012)

Abstract B- and T-cell subtypes of prolymphocytic leukemia (PLL) are rare, aggressive lymphoid malignancies with characteristic morphologic, immunophenotypic, cytogenetic, and molecular features. Prognosis for these patients remains poor, with short survival times and no curative therapy. The advent of mAbs has improved treatment options. In B-PLL, rituximab-based combination chemoimmunotherapy is effective in fitter patients. TP53 abnormalities are common and, as for chronic lymphocytic leukemia, these patients should generally be managed using an alemtuzumab-based therapy. Currently, the best treatment for T-PLL is IV alemtuzumab, which has resulted in very high response rates of more than 90% when given as frontline treatment and a significant improvement in survival. Consolidation of remissions with autologous or allogeneic stem cell transplantation further prolongs survival times, and the latter may offer potential cure. The role of allogeneic transplantation with nonmyeloablative conditioning needs to be explored further in both T- and B-PLL to broaden the patient eligibility for what may be a curative treatment.
A New Measurement Technique for Tracking Voltage Phasors, Local System Frequency, and Rate of Change of Frequency (1983)

With the advent of Substation Computer Systems dedicated to protection, control and data logging functions in a Substation, it becomes possible to develop new applications which can utilize the processing power available within the substation. The microcomputer based Symmetrical Component Distance Relay (SCDR) described in the references cited at the end of this paper possesses certain characteristics which facilitate real-time monitoring of positive sequence voltage phasor at the local power system bus. With a regression analysis the frequency and rate-of-change of frequency at the bus can also be determined from the positive sequence voltage phase angle. This paper describes the theoretical basis of these computations and describes results of experiments performed in the AEP power system simulation laboratory. Plans for future field tests on the AEP system are also outlined.
BIOLOGICAL BASIS OF SUBSTANCE ABUSE (1993)

This volume describes our current understanding of the biological mechanisms in the central nervous system of nicotine, alcohol, cocaine, heroin, marijuana, and other drugs of abuse. Organized to focus on the similarities rather than the differences between drug actions, the processes undergo examination by level of cellular organization rather than by substance. The book proceeds from characterization of drug effects in relation to neurotransmitters and their receptors, through localization of drug effects in the brain in relation to specific anatomic structures. The impact of local stimulation or lesions on animal behaviors with respect to reward, reinforcement, desensitization and sensitization receive attention. Human genetic studies and therapeutic trials of addiction management complete the presentations.
A study of medical and health queries to web search engines (2004)

This paper reports findings from an analysis of medical or health queries to different web search engines. We report results: (i). comparing samples of 10000 web queries taken randomly from 1.2 million query logs from the AlltheWeb.com and Excite.com commercial web search engines in 2001 for medical or health queries, (ii). comparing the 2001 findings from Excite and AlltheWeb.com users with results from a previous analysis of medical and health related queries from the Excite Web search engine for 1997 and 1999, and (iii). medical or health advice-seeking queries beginning with the word 'should'. Findings suggest: (i). a small percentage of web queries are medical or health related, (ii). the top five categories of medical or health queries were: general health, weight issues, reproductive health and puberty, pregnancy/obstetrics, and human relationships, and (iii). over time, the medical and health queries may have declined as a proportion of all web queries, as the use of specialized medical/health websites and e-commerce-related queries has increased. Findings provide insights into medical and health-related web querying and suggests some implications for the use of the general web search engines when seeking medical/health information.
Two-photon nanolithography of positive photoresist thin film with ultrafast laser direct writing (2013)

The authors investigate two-photon nanolithography of a positive photoresist thin film and the influence factor of spatial resolution. A spatial resolution of 85 nm, about one-ninth of the laser wavelength at 780 nm, has been realized by using commercial positive AZ P4620 photoresist. Theoretical analysis based on the exposure kinetics of photoactive compound of diazonaphthoquinone is consistent with experimental results. The trench's cross-section shape and spatial resolution are influenced by the standing wave interference caused by the incident and reflected light. This study would provide a protocol for fabricating micro/nanodevices by femtosecond laser direct writing of positive photoresists.
A Mesh Reduction Approach to Parametric Surface Polygonization (1995)

Abstract Surface polygonization is the process by which a representative polygonal mesh of a surface is constructed for rendering or analysis purposes. This work presents a new surface polygonization algorithm specifically tailored to be applied to a large class of models which are created with parametric surfaces. This method has particular application in the area of building virtual environments from computer-aided-design (CAD) models. The algorithm is based on an edge reduction scheme that collapses two vertices of a given polygon edge onto one new vertex. A two step approach is implemented consisting of boundary edge reduction followed by interior edge reduction. A maximin optimization is used to determine the location of the new vertex. The concept of a visible region as the location space of the new vertex is introduced. The method presented here differs from existing methods in that it takes advantage of the fact that for many models, the exact surface representation of the model is known before the polygonization is attempted. Because the precise surface definition is known, a maximin optimization procedure, that uses the surface information, can be used to locate the new vertex. The algorithm attempts to overcome the deficiencies in existing techniques while minimizing the number of polygons required to represent a surface and still maintaining surface integrity in the rendered model. This paper presents the algorithm and testing results.
In Vitro and In Vivo Inhibition of <i>Helicobacter pylori</i> by <i>Lactobacillus casei</i> Strain Shirota (2004)

We studied the potential inhibitory effect of Lactobacillus casei strain Shirota (from the fermented milk product Yakult [Yakult Ltd., Tokyo, Japan]) on Helicobacter pylori by using (i) in vitro inhibition assays with H. pylori SS1 (Sydney strain 1) and nine H. pylori clinical isolates and (ii) the in vivo H. pylori SS1 mouse model of infection over a period of 9 months. In vitro activity against H. pylori SS1 and all of the clinical isolates was observed in the presence of viable L. casei strain Shirota cells but not in the cell-free culture supernatant, although there was profound inhibition of urease activity. In vivo experiments were performed by oral administration of L. casei strain Shirota in the water supply over a period of 9 months to 6-week-old C57BL/6 mice previously infected with H. pylori SS1 (study group; n = 25). Appropriate control groups of H. pylori-infected but untreated animals (n = 25) and uninfected animals given L. casei strain Shirota (n = 25) also were included in the study. H. pylori colonization and development of gastritis were assessed at 1, 2, 3, 6, and 9 months postinfection. A significant reduction in the levels of H. pylori colonization was observed in the antrum and body mucosa in vivo in the lactobacillus-treated study group, as assessed by viable cultures, compared to the levels in the H. pylori-infected control group. This reduction was accompanied by a significant decline in the associated chronic and active gastric mucosal inflammation observed at each time point throughout the observation period. A trend toward a decrease in the anti-H. pylori immunoglobulin G response was measured in the serum of the animals treated with lactobacillus, although this decrease was not significant.
Tetracycline Up-Regulates COX-2 Expression and Prostaglandin E2 Production Independent of Its Effect on Nitric Oxide (1999)

Tetracyclines (doxycycline and minocycline) augmented (one- to twofold) the PGE2 production in human osteoarthritis-affected cartilage (in the presence or absence of cytokines and endotoxin) in ex vivo conditions. Similarly, bovine chondrocytes stimulated with LPS showed (one- to fivefold) an increase in PGE2 accumulation in the presence of doxycycline. This effect was observed at drug concentrations that did not affect nitric oxide (NO) production. In murine macrophages (RAW 264.7) stimulated with LPS, tetracyclines inhibited NO release and increased PGE2 production. Tetracycline(s) and L-N-monomethylarginine (L-NMMA) (NO synthase inhibitor) showed an additive effect on inhibition of NO and PGE2 accumulation, thereby uncoupling the effects of tetracyclines on NO and PGE2 production. The enhancement of PGE2 production in RAW 264.7 cells by tetracyclines was accompanied by the accumulation of both cyclooxygenase (COX)-2 mRNA and cytosolic COX-2 protein. In contrast to tetracyclines, L-NMMA at low concentrations (< or = 100 microM) inhibited the spontaneous release of No in osteoarthritis-affected explants and LPS-stimulated macrophages but had no significant effect on the PGE2 production. At higher concentrations, L-NMMA (500 microM) inhibited NO release but augmented PGE2 production. This study indicates a novel mechanism of action of tetracyclines to augment the expression of COX-2 and PGE2 production, an effect that is independent of endogenous concentration of NO.
[The atrial arrhythmia syndrome of vagal origin]. (1978)

Having observed 18 cases, the authors describe a syndrome of recurrent paroxysmal atrial arrhythmia which was very homogeneous from the clinical and ECG point of view. It was usually found in middle aged males, with no demonstrable underlying heart disease, whose disorder of intra-atrial conduction occurred during sinus rhythm. The condition developed slowly over the course of years towards a maximum incidence of several short daily attacks of an arrhythmia which alternated between an atrial fibrillation and atrial flutter. Vagal overactivity is the precipitating cause of these attacks which are usually not completely nocturnal. The condition never progressed to sino-atrial block nor to permanent fibrillation. The beginning of each attack, often heralded by atrial coupling with a long enough interval to cause re-entry, is accompanied by slowing of the sinus rate down to the threshold level. The vagal effect of shortening the action potential and refractory period is recognised to be non-homogeneous in the atrial wall, and suggests a re-entry mechanism rather than hyper-excitability. This would explain the usual resistance of atrial arrhythmias of vagal origin to digitalis, beta blockers and quinidine. Amiodarone alone is usually effective because of the prolongation of the action potential which it causes. In 5 particularly resistant cases a good clinical result was obtained by the insertion of an atrial pacemaker with a fairly rapid rate.