gebhart/patrepeval huggingface dataset:
A Review of Gene Expression Profiling of Human Embryonic Stem Cell Lines and their Differentiated Progeny (2009)

One of the key characteristics of human embryonic stem cells (hESC) is their ability to proliferate for an indefinite period of time. Previous studies have shown that a unique network of transcription factors are involved in hESC self renewal. Since hESC lines have the potential to differentiate into cells of all three germ layers, cells derived from hESC may be useful for the treatment of a variety of inherited or acquired diseases. The molecular signal required to differentiate hESC into a particular cell type has not been defined. It is expected that global gene expression profiling of hESC may provide an insight into the critical genes involved in maintaining pluripotency of hESC and genes that are modulated when hESCs differentiate. Several groups have utilized a variety of high throughput techniques and performed gene expression profiling of undifferentiated hESCs and mouse ES cells (mESC) to identify a set of genes uniquely expressed in ES cells but not in mature cells and defined them as "stemness" genes. These molecular techniques include DNA microarray, EST-enumeration, MPSS profiling, and SAGE. Irrespective of the molecular technique used, highly expressed genes showed similar expression pattern in several ES cell lines supporting their importance. A set of approximately 100 genes were identified, which are highly expressed in ES cells and considered to be involved in maintaining pluripotency and self renewal of ES cells. Various studies have also reported on the gene expression profiling of differentiated embryoid bodies (EB) derived from hESCs and mESCs. When hESCs are differentiated, "stemness" genes are down-regulated and a set of genes are up-regulated. Together with down-modulation of "stemness" genes and up-regulation of new genes may provide a new insight into the molecular pathways of hESC differentiation and study of these genes may be useful in the characterization of differentiated cells.
Mesoporous Nano‐Si Anode for Li‐ion Batteries Produced by Magnesio‐Mechanochemical Reduction of Amorphous SiO<sub>2</sub> (2013)

Abstract The synthesis of nano‐sized Si with various microstructures has been studied intensively to produce anode materials for Li‐rechargeable batteries. Methods such as chemical/physical vapor deposition (CVD/PVD) and wet‐chemical processes are currently used to produce nano‐sized Si; however, the complicated synthesis procedures and low production yields are critical problems that hinder commercialization. We present a method for producing large quantities of mesoporous nano‐sized Si through the reduction of amorphous SiO 2 with Mg metal, by using a high‐energy mechanical milling process (i.e., magnesio‐mechanochemical processing) for 1 h. A mesoporous nano‐sized Si electrode shows excellent electrochemical performance as an anode for Li‐ion batteries, achieving a capacity greater than 1600 mAh g −1 over 30 cycles.
Ban Hat in Champasak Province (Laos) to Stung Treng (Cambodia) (2011)

The Greater Mekong Sub-region Power Trade Project consists of mainly two construction works. One is the construction of a transmission line of 82km from Ban Hat substation to Stung Treng substation. Responsibility of the Laotian side is the 25.7km distance between Ban Hat Substation and the Lao-Cambodian border. The other construction work is the expansion of the existing Ban Hat Substation to connect the above-mentioned transmission lines. Based on the survey during the Initial Environmental Examination (IEE), no people will be resettled. Moreover, no structural assets, spiritual or cultural property will be affected. The main negative aspects will come from some permanent land losses and temporary land occupation. The affected people will be given every opportunity to have redress to their grievances.
Reliable Monitoring of Network-related Performance Parameters inWireless Environments (2006)

End-to-end delay estimation is a crucial issue in the design of network monitoring systems for wireless best-effort infrastructures. This work demonstrates that estimations based on one-way delay are the most suitable for evaluating the delay on wireless networks such as Wi-Fi LANs and Bluetooth piconets. To prevent delay measurement from being affected by clock synchronization issues, raw measures need to be corrected by estimating clock synchronism attributes such as clock skew and offset. However, due to network noise and clock adjustments, this estimation process may affect the reliability of network monitoring systems. In this paper, we propose a trustworthy network performance monitor designed to support adaptive and/or soft real-time applications in wireless environments. The monitor corrects one-way delay measurements through an on-line algorithm for evaluating clock synchronism attributes. Simulation experiments show the effectiveness of our approach.
Resistance to a Protein Farnesyltransferase Inhibitor in Plasmodium falciparum (2005)

The post-translational farnesylation of proteins serves to anchor a subset of intracellular proteins to membranes in eukaryotic organisms and also promotes protein-protein interactions. Inhibition of protein farnesyltransferase (PFT) is lethal to the pathogenic protozoa Plasmodium falciparum. Parasites were isolated that were resistant to BMS-388891, a tetrahydroquinoline (THQ) PFT inhibitor. Resistance was associated with a 12-fold decrease in drug susceptibility. Genotypic analysis revealed a single point mutation in the beta subunit in resistant parasites. The resultant tyrosine 837 to cysteine alteration in the beta subunit corresponded to the binding site for the THQ and peptide substrate. Biochemical analysis of Y837C-PFT demonstrated a 13-fold increase in BMS-388891 concentration necessary for inhibiting 50% of the enzyme activity. These data are consistent with PFT as the target of BMS-388891 in P. falciparum and suggest that PFT inhibitors should be combined with other antimalarial agents for effective therapy.
Analysis of Hybrid MOSFET/IGBT Switches Utilized in High Frequency Resonant Converters (2014)

The objective of connecting a MOSFET and an IGBT in parallel is to combine the advantages of both semiconductor technologies. Such hybrid switches have been investigated in a high frequency test setup for resonant converters. These converters are commonly used in high voltage generators (e.g. for medical applications). In this paper three MOSFETs connected in parallel are replaced by a single hybrid switch. For this, a corresponding super-junction MOSFET has been combined with different IGBTs from several manufacturers. The performance of these hybrid switches has been analyzed by efficiency measurements within the test setup for different operating points.
Demonstration of optical packet switching scheme for header-payload separation and class-based forwarding (2004)

We propose and experimentally verify a design realizing a novel scheme for key optical packet switching functionalities: header-payload separation, class of service segregation and packet forwarding.
De buitenplaats Petersburg, een ontwerp van Simon Schijnvoet (2012)

A ground plan of the country estate Petersburg near Nigtevegt has been preserved in the Beudeker collection (Ms. C.9.e.l1) in the British Map Library. This country estate was built by Simon Schijnvoet (1652-1727), commissioned by Christoffel Brants (1664-1732) between 1709 and 1717. The drawing is bound with an edition of De zegepralende Vecht (The triumphant river Vecht) (1719) and precedes twelve engravings of this country estate made by Daniel Stoopendaal. By means of the drawing these prints can be placed in their compositional context. In general, such prints show what used to be there, but on comparison, small differences are to be seen. The triangle gives the property a remarkable basic form. The main issue was that the site had to fit in with adjacent lots. But the triangular form with its planted avenues (illustration 1) is also to be linked up with the overgrown fortresses in Holland. Besides, fortification was a favourite subject of czar Peter the Great, for whom the construction was intended. The foundations of his town, St. Petersburg, were started with a fort. The variegation of land and water and several other details of the layout betray that the owner wished to build a 'Peter's Burg'. The layout of the garden does not show the customary symmetrical arrangement. The main axis behind the house is the visible axis but not the central one. A long traverse axis with side paths led to the various components of the garden providing an overwhelming sight and a varied walk for the guests. Schijnvoet was a capable amateur, who schooled himself with the aid of his collection of books and prints. An iconographical garden planning is not to be traced from the sculptures visible on the prints, but the many garden vases dominate. They may have been made after a design by Schijnvoet. There is a volume of 54 prints made by him, showing designs for garden decoration, including 24 examples of garden vases. The country estate Petersburg shows the significance of Schijnvoet: he was a high-level amateur and inventor mastering several 'fields of study'.
Availability of Phosphorus in Rock Phosphate‐Sulfur Fusions<sup>1</sup> (1965)

Synopsis Recovery of P by ryegrass was inversely related to granule size and ratio of rock phosphate to sulfur. Both the 1:1 and 2:1 ratios of −40 mesh granules compared favorably with superphosphate as a source of P. Recovery of P from fusions added to calcareous soils was quite low. After 4 weeks incubation, the amounts of sulfur oxidized were quite similar for soil moisture contents between two‐thirds and twice field moisture capacity.
TH‐A‐211‐01: Deformable Registration in the Clinic: From Commissioning to Advanced Applications (2012)

With deformable registration presented by several companies as a tool to improve treatment accuracy, clinical users often question the advantages and disadvantages of adopting this sophisticated technology to daily practice. This course will detail our experience in using deformable registration in the clinic. It will cover topics such as commissioning a system of deformable registration, patient‐specific QA to identify errors in the displacement field, common applications, anticipated changes in the clinical workflow and subsequent time savings. Emphasis will be placed on explaining the technology's mathematics and applications in layman terms to illustrate how various parameters can be chosen to fit various applications or can produce significant errors if improperly selected. Learning Objectives: 1. Detail the installation and commissioning 2. Present how parameter selection influence results 3. Show clinical examples and practical conclusions drawn from the daily use of deformable registration.
Noise suppression in low-light images through joint denoising and demosaicing (2011)

We address the effects of noise in low-light images in this paper. Color images are usually captured by a sensor with a color filter array (CFA). This requires a demosaicing process to generate a full color image. The captured images typically have low signal-to-noise ratio, and the demosaicing step further corrupts the image, which we show to be the leading cause of visually objectionable random noise patterns (splotches). To avoid this problem, we propose a combined framework of denoising and demosaicing, where we use information about the image inferred in the denoising step to perform demosaicing. Our experiments show that such a framework results in sharper low-light images that are devoid of splotches and other noise artifacts.
NCIC CTG MA.17: Intent to treat analysis (ITT) of randomized patients after a median follow-up of 54 months (2006)

549 Background: MA.17 evaluated letrozole (LET) or placebo (PLAC) after 5 years of tamoxifen (Tam) and showed [median follow-up 30 months (mos)] significant improvement in disease-free survival (DFS) for LET [hazard ratio (HR) 0.57, p = 0.00008]. The trial was unblinded and PLAC patients (pts) were offered LET. An ITT analysis of all outcomes, before and after unblinding, based on the original randomization was performed. Methods: A stratified log-rank test was used to compare DFS, distant (D)DFS, overall survival (OS) and incidence of contra-lateral breast cancer (CBC). The Cox regression model used baseline stratification variables and two prespecified factors, menopausal status at the start of Tam and time on Tam. Subgroup analyses for DFS and OS were performed for the two prespecified subsets. All p-values were two-sided Results: 5187 pts were randomized at baseline and, at unblinding, 1655 of 2268 PLAC pts accepted LET. At median follow-up of 54 mos (range,16–86) 363 recurrences or CBC’s (144 LET and 219 PLAC) occurred; 118 LET and 176 PLAC pts had recurrent disease and 26 LET and 43 PLAC pts had CBC. 4 year DFS was 94.3% (LET) and 91.4% (PLAC) (HR 0.64; 95% CI, 0.52 - 0.79; p = 0.00002). Corresponding 4 year DDFS was 96.2% and 94.9% (HR 0.76; 0.58–0.99; p = 0.041). 4 year OS was 95.0% (LET) and 95.1% (PLAC) (HR 1.00; 0.78–1.28; p = 0.99). LET was equally effective in node +ve and -ve pts (i.e., similar HRs) in DFS. OS was not significantly different for LET and PLAC in any subgroup. The annual rate of CBC was 0.29% LET (0.18–0.40) and 0.47% PLAC (0.34–0.61); HR 0.61 (0.38–0.98) p = 0.037. 255 pts had died as of the data cut-off (128 LET and 127 PLAC). Conclusions: In this ITT analysis, pts originally randomized to LET within 3 months of stopping Tam did better than PLAC pts in DFS, DDFS and CBC, despite 73% of PLAC pts crossing to LET after unblinding. This highlights the strong beneficial effect of extended adjuvant therapy with LET. [Table: see text]
Haptic Devices for Virtual Reality, Telepresence, and Human-Assistive Robotics (2017)

Biomimetic systems attempt to copy the form or the behavior of biological systems to create efficient machines and processes. Since nature has had millions upon millions of years to perfect these systems, it is logical to learn from them when designing machines and processes. Another way to use the tools that nature has built is to design machines that specifically incorporate a human into the system. These biologically incorporated systems extend the capabilities of machines by adding a human component, or extend the abilities of humans with the assistance of human-made devices. The interfaces used to connect these human and machine systems together are the human senses. These interface systems can truly be called biomimetic systems in that they are designed to respond to, or mimic, the reactions and sensations of a biological system, namely the human operator. Various systems currently exist that provide information to the human senses of sight and hearing. Audio and video systems have been perfected over many decades so that it is now possible for a user to wear small devices such as goggles and earphones that allow a user to see and hear various forms of information. Systems also currently exist, and others are being further developed, that interface with a third human sense, the sense of touch. These systems are called haptic systems or simply haptics. The inclusion of haptic systems such as the ones presented in the following sections allows for the creation of fully immersive environments that can provide a user with the three major inputs of visual, auditory, and haptic information. These systems can be used for virtual reality and telepresence applications. The ability to generate visual, auditory, and haptic stimuli makes it possible to accurately generate almost any environment that is desired in a believable and immersive manner.
Housekeeping Na,K-ATPase alpha 1 subunit gene promoter is composed of multiple cis elements to which common and cell type-specific factors bind. (1992)

Na,K-ATPase alpha 1 subunit gene (ATP1A1) is one of the housekeeping genes involved in homeostasis of Na+ and K+ in all animal cells. We identified and characterized the cis-acting elements that regulate the expression of ATP1A1. The region between -155 and -49 was determined as a positive regulatory region in five cultured cell lines of different tissue origins (MDCK, B103, L6, 3Y1, and HepG2). The region was divided into three subregions: from -120 to -106 (including the Sp1 binding site), from -102 to -61, and from -58 to -49 (including an Sp1 consensus sequence). Cell type-specific factors binding to the middle subregion (from -102 to -61) were detected by gel retardation analysis, using nuclear extracts prepared from MDCK and B103 cells. Two gel retardation complexes were formed in the B103 nuclear extract, and three were formed in the MDCK nuclear extract. DNA binding regions of these factors were located at -88 to -69 and differed from each other in DNase I footprinting experiments. These factors also showed different binding characteristics in gel retardation competition and methylation interference experiments. The identified cis element was named the ATP1A1 regulatory element. The core sequence of this element is found in several other genes involved in cellular energy metabolism, suggesting that the sequence is a common regulatory element responsive to the state of energy metabolism.
Preparation and Reactions of o-Hydroxycinnamic Acids and Esters (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Reactions of o-Hydroxycinnamic Acids and EstersRoger Adams and Theodore E. BockstahlerCite this: J. Am. Chem. Soc. 1952, 74, 21, 5346–5348Publication Date (Print):November 1, 1952Publication History Published online1 May 2002Published inissue 1 November 1952https://pubs.acs.org/doi/10.1021/ja01141a038https://doi.org/10.1021/ja01141a038research-articleACS PublicationsRequest reuse permissionsArticle Views1247Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-speed photography (1979)

Report on The Association for High Speed Photography, 4 October 1978 at Imperial College of Science and Technology, London.
Whisky Lactone Precursors from the Wood of <i>Platycarya strobilacea</i> (1996)

The first whisky lactone precursors, (3S,4S)-3-methyl-4-hydroxyoctanoic acid 3-O-β-d-glucopyranoside and its 6‘-O-gallate, were isolated from the wood of Platycarya strobilacea, together with 10 known tannins and related compounds. Their structures were determined on the basis of spectroscopic and chemical evidence.
Sequelae in Adults at 6 Months After COVID-19 Infection (2021)

This cohort study analyzed persistent symptoms among adults with coronavirus disease 2019 up to 9 months after illness onset.
Export processing zones : has Africa missed the boat ? not yet ! (2001)

Attempts in Africa to use Export Processing Zones (EPZ) as an instrument for economic development, with the exception of Mauritius, have been less successful then in countries in East Asia, Central America, and the Caribbean basin. This paper examines the literature on Export Processing and Free Trade Zones. Successful zones in Mauritius, Tangiers, Panama, and the Dominican Republic, were visited and investors, developers and government officials in the zones were interviewed in order to determine what were the factors that resulted in their success. The paper concludes that there is substantial potential for African countries to benefit from export-oriented growth based on the development of EPZs. Any country attempting to develop an EPZ program will have to enlist the concerted and coordinated support of its development partners in the implementation of its program.
Tissue-Culture Biocompatibility Testing Program (1983)

Four methods of in vitro biocompatibility screening using L-929 mouse fibroblast cells are discussed, namely, the fluid medium, agar diffusion, flask dilution, and flask dilution extraction methods. The range of test methods allows toxicity screening of both solid and liquid specimens and has been shown to provide good agreement with and better sensitivity than the United States Pharmacopeia (USP) rabbit muscle implantation assay. Approximately 2000 specimens are subjected to such in vitro evaluations annually at our facility for evaluating stability studies, component changes, formulations, and manufacturing processes. A scale of 0 to 4+ is used to indicate the extent of cellular damage providing a quantitation of toxic response.
A Review of Intrusion Detection Systems Using Machine and Deep Learning in Internet of Things: Challenges, Solutions and Future Directions (2020)

The Internet of Things (IoT) is poised to impact several aspects of our lives with its fast proliferation in many areas such as wearable devices, smart sensors and home appliances. IoT devices are characterized by their connectivity, pervasiveness and limited processing capability. The number of IoT devices in the world is increasing rapidly and it is expected that there will be 50 billion devices connected to the Internet by the end of the year 2020. This explosion of IoT devices, which can be easily increased compared to desktop computers, has led to a spike in IoT-based cyber-attack incidents. To alleviate this challenge, there is a requirement to develop new techniques for detecting attacks initiated from compromised IoT devices. Machine and deep learning techniques are in this context the most appropriate detective control approach against attacks generated from IoT devices. This study aims to present a comprehensive review of IoT systems-related technologies, protocols, architecture and threats emerging from compromised IoT devices along with providing an overview of intrusion detection models. This work also covers the analysis of various machine learning and deep learning-based techniques suitable to detect IoT systems related to cyber-attacks.
A Phase <scp>II</scp> trial of Belinostat ( <scp>PXD</scp> 101) in patients with relapsed or refractory peripheral or cutaneous T‐cell lymphoma (2014)

Belinostat is a pan-histone deacetylase inhibitor with antitumour and anti-angiogenic properties. An open label, multicentre study was conducted in patients with peripheral T-cell lymphoma (PTCL) or cutaneous T-cell lymphoma (CTCL) who failed ≥1 prior systemic therapy and were treated with belinostat (1000 mg/m(2) intravenously ×5 d of a 21-d cycle). The primary endpoint was objective response rate (ORR). Patients with PTCL (n = 24) had received a median of three prior systemic therapies (range 1-9) and 40% had stage IV disease. Patients with CTCL (n = 29) had received a median of one prior skin-directed therapy (range 0-4) and four prior systemic therapies (range 1-9); 55% had stage IV disease. The ORRs were 25% (PTCL) and 14% (CTCL). Treatment-related adverse events occurred in 77% of patients; nausea (43%), vomiting (21%), infusion site pain (13%) and dizziness (11%) had the highest incidence. Treatment-related serious adverse events were Grade 5 ventricular fibrillation; Grade 4 thrombocytopenia; Grade 3 peripheral oedema, apraxia, paralytic ileus and pneumonitis; and Grade 2 jugular vein thrombosis. Belinostat monotherapy was well tolerated and efficacious in patients with recurrent/refractory PTCL and CTCL. This trial was registered at www.clinicaltrials.gov as NCT00274651.