gebhart/patrepeval huggingface dataset:
Time-limited orthogonal multicarrier modulation schemes (1995)

Time-limited orthogonal (TLO) multicarrier modulation (MCM) schemes with waveform shaping are investigated. The waveform shaped scheme with no frame overlap is spectrally inefficient. An improved scheme is proposed and it is shown that this scheme allows a certain amount of overlap between adjacent frames without destroying the orthogonality, the scheme is therefore spectrally efficient. The improved TLO MCM scheme can be regarded as a time domain dual form of Chang's band-limited orthogonal MCM (1966).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Characterization of a Small Molecular Size Urinary Immunoreactive Human Chorionic Gonadotropin (hCG) Like Substance Produced by Normal Placenta and by hCG-Secreting Neoplasms* (1981)

Urine obtained from normal pregnant women as well as from patients with hCG-secreting tumors frequently contains native hCG and free hCG subunits when separated on Sephadex G-100. In addition, a small amount of an immunoreactive, hCG-like, low molecular weight substance is usually observed in those chromatograms and represents less than 1% of the total immunoreactive hCG present. Two patients with widely metastatic hCG-secreting tumors excreted disproportionately large quantities of that low molecular weight substance, and that observation raised the possibility that this substance was a secretory and not a degradative product of the hCG molecule. The small immunoreactive hCG-like substance was subsequently characterized immunologically, biologically, and physically. The hCG fragment displayed a biphasic dose-response line in a homologous hCG RIA. The slope of the upper portion of the dose-response line was equal to that for native hCG, but the slope of the lower component of the dose-response line was significantly different from that for hCG. The immunoreactive hCG substance cross-reacted with hCG beta but not with either hCG alpha or hCG beta carboxyl-terminus. The small molecular size immunoreactive hCG-like substance bound to Concanavalin A-Sepharose 4B and eluted with 0.2 M alpha-D-methyl glucopyranoside, contained no significant intrinsic biological activity when tested in the in vitro Leydig cell bioassay and also failed to compete with labeled hCG for specific ovarian LH/hCG receptors. Consequently, that small urinary immunoreactive hCG substance behaved neither as a hCG agonist or antagonist. It exhibited a plasma half-life of 4.5 min when the appropriate Sephadex G-100 fractions were injected into immature female rats. The small molecular size immunoreactive hCG-like substance may be a secretory or breakdown product of hCG-secreting cells.
Death by apple juice: the problem of foodborne illness, the regulatory response, and further suggestions for reform. (1998)

One of the greatest challenges facing regulatory government today concerns the safety of the food supply. Few Americans realize the extent and severity of the danger posed by foodborne pathogens. While many of these microorganisms are not new, changes in food production, preparation, and consumption patterns have resulted in unprecedented opportunities for the widespread transmission of foodborne illness. Unfortunately, this problem is predicted to intensify in the years to come. Part I of this article explores the foodborne illness problem in detail, with special attention to recent outbreaks, possible contributing factors, and the historical regulatory approach. Part II discusses the federal government's response, including President Clinton's Food Safety Initiative. Part III provides a critique of government action and further suggestions for reform. The American food supply is unquestionably the safest in the world. Compared to other countries, American consumers enjoy an unparalleled variety of high quality foods at relatively low prices. Even so, it is believed that millions become ill and thousands die each year from the consumption of government-regulated foods. [FN3] Indeed, the technology necessary to better identify the scope of the danger presented by foodborne illness is just now developing.
Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer cells, macrophages and microbes (2013)

Several amphiphilic, chalcogen-based redox modulators have been synthesized which exhibit a widespread, yet in some instances also selective, biological activity which is most likely based on their ability to modulate the intracellular redox balance and to interact with cellular membranes and specific proteins.
Cutaneous manifestations of opportunistic infections in patients infected with human immunodeficiency virus (1995)

Bacillary angiomatosis (BA) presents most commonly as a cutaneous disease and is caused by two organisms. Bartonella (Rochalimaea) henselae and Bartonella (Rochalimaea) quintana. Biopsy confirmation of cutaneous BA is essential because lesions can mimic nodular Kaposi's sarcoma in appearance. Although the vast majority of human immunodeficiency virus (HIV)-infected patients with BA have CD4 lymphocyte counts of less than 100 cells per mm3, the disease responds well to antimicrobial therapy. Staphylococcus aureus is the most common bacterial skin pathogen affecting HIV-infected patients. The prevalence of skin disease due to S. aureus may be explained by high nasal carriage rates for the organism ( > or = 50%) and altered immune function in conjunction with an impaired cutaneous barrier. Herpes simplex virus causes mucocutaneous disease early in the course HIV infection and ulcerative lesions at any site in advanced HIV infection. Herpes zoster is common early in the course of HIV infection; recurrent and disseminated herpes zoster infections are characteristic of patients with advanced HIV disease. Acyclovir resistance is usually seen in patients with large, untreated, ulcerative lesions of herpes simplex virus and in patients with chronic, verrucous lesions of varicella-zoster virus. Cutaneous cryptococcosis, histoplasmosis, and coccidiomycosis are markers of disseminated disease and require biopsy confirmation. Scabies is easily diagnosed but may be atypical in presentation and difficult to eradicate in advanced HIV disease.
Multi-camera face detection and recognition applied to people tracking (2013)

This thesis describes the design and implementation of a framework that can track and identify multiple people in a crowded scene captured by multiple cameras. A people detector is initially employed to estimate the position of individuals. Those positions estimates are used by the face detector to prune the search space of possible face locations and minimize the false positives. A face classifier is employed to assign identities to the trajectories. Apart from recognizing the people in the scene, the face information is exploited by the tracker to minimize identity switches. Only sparse face recognitions are required to generate identity-preserving trajectories. Three face detectors are evaluated based on the project requirements. The face model of a person is described by Local Binary Pattern (histogram) features extracted from a number of patches of the face, captured by different cameras. The face model is shared between cameras meaning that one camera can recognize a face relying on patches captured by a different camera. Three classifiers are tested for the recognition task and an SVM is eventually employed. Due to the properties of the LBP, the recognition is robust to illumination changes and facial expressions. Also the SVM is trained from multiple views of the face of each person making the recognition also robust to pose changes. The system is integrated with two trackers, the state-of-the-art Multi-Commodity Network Flow tracker and a frame-by-frame Kalman tracker. We validate our method on two datasets generated for this purpose. The integration of face information with the people tracker demonstrates excellent performance and significantly improves the tracking results on crowded scenes, while providing the identities of the people in the scene.
Ginkgo biloba Extract EGb761 Attenuates Hyperhomocysteinemia-induced AD Like Tau Hyperphosphorylation and Cognitive Impairment in Rats (2017)

EGb761 might be a promising drug to treat AD through its anti-oxidative activity and decreasing tau hyperphosphorylation besides the protection against the Aβ-induced neurotoxicity.
LOSARTAN, AN ANGIOTENSIN-II RECEPTOR ANTAGONIST, REDUCES HEMATOCRITS IN KIDNEY TRANSPLANT RECIPIENTS WITH POSTTRANSPLANT ERYTHROCYTOSIS (1997)

We conclude that blockade of the type 1 angiotensin II receptor is safe and effective in treating PTE.
Construct Validity and Frequency of Euphoria Sclerotica in Multiple Sclerosis (2004)

Using the Neuropsychiatric Inventory (NPI), we studied euphoria and other behavioral changes in 75 consecutive, unselected multiple sclerosis (MS) patients and 25 healthy controls. We also assessed disease duration, clinical course, physical disability, personality, depression, insight, cognition, and caregiver distress. Factor analysis identified a cluster of symptoms--labeled euphoria/disinhibition--similar to the euphoria sclerotica syndrome originally described by Charcot and others. The euphoria/disinhibition factor score was elevated in 9% of patients and associated with secondary-progressive course, low agreeableness, poor insight, impaired cognition, and high caregiver distress. Thus, we used the NPI to validate the euphoria syndrome in multiple sclerosis (MS) and determined its frequency, and its neurological and psychological correlates.
Trends in Virtual Combinatorial Library Design (2002)

Recent developments in combinatorial molecular design using virtual screening methods are summarised. These include similarity-based compound clustering techniques, structure-based docking and scoring, and fragment-based de novo design. Three major trends have been identified: i) the design of small target-focused compound libraries yielding activity-enriched sets of molecules; ii) advanced prediction methods for "drug-like" molecular properties complement activity predictions in the library design process, forming a multi-dimensional objective function; iii) "cherry picking" of selected products is increasingly used in lead generation and optimisation compared to purely educt-driven library design methods aiming at maximising structural diversity.
Stability of high-concentration dopamine hydrochloride, norepinephrine bitartrate, epinephrine hydrochloride, and nitroglycerin in 5% dextrose injection (1997)

Journal Article Stability of high-concentration dopamine hydrochloride, norepinephrine bitartrate, epinephrine hydrochloride, and nitroglycerin in 5% dextrose injection Get access Tom E. Peddicord, Pharm.D., Tom E. Peddicord, Pharm.D. Critical Care/ASHP Research and Education Foundation Immunology Fellow University of Nebraska Medical Center (UNMC), Omaha Search for other works by this author on: Oxford Academic Google Scholar Keith M. Olsen, Pharm.D., FCCP, Keith M. Olsen, Pharm.D., FCCP Associate Professor of Pharmacy University of Nebraska Medical Center (UNMC), Omaha Address reprint requests to Dr. Olsen at the College of Pharmacy, University of Nebraska Medical Center, 600 S. 42nd Street, Box 986045, Omaha, NE 68198-6045, or to kolsen@mail.unmc.edu. Search for other works by this author on: Oxford Academic Google Scholar Troy L. ZumBrunnen, Pharm.D., Troy L. ZumBrunnen, Pharm.D. Solvay Pharmaceuticals/Mercer University Clinical Research Fellow Mercer University, Atlanta, GA; at the time of this study he was a Pharm.D. degree student, UNMC Search for other works by this author on: Oxford Academic Google Scholar David J. Warner, Pharm.D., David J. Warner, Pharm.D. Clinical Pharmacist UNMC Search for other works by this author on: Oxford Academic Google Scholar Lauren Webb, Pharm.D. Lauren Webb, Pharm.D. degree student UNMC Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 54, Issue 12, 15 June 1997, Pages 1417–1419, https://doi.org/10.1093/ajhp/54.12.1417 Published: 15 June 1997
104 MHz rate single-shot recording with subpicosecond resolution using temporal imaging (2013)

We demonstrate temporal imaging for the measurement and characterization of optical arbitrary waveforms and events. The system measures single-shot 200 ps frames at a rate of 104 MHz, where each frame is time magnified by a factor of -42.4x. Impulse response tests show that the system enables 783 fs resolution when placed at the front end of a 20 GHz oscilloscope. Modulated pulse trains characterize the system's impulse response, jitter, and frame-to-frame variation.
Kinetics of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">H</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>passivation of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi>P</mml:mi></mml:mrow><mml:mrow><mml:mi>b</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>centers at the (111) Si-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">SiO</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>interface (1988)

This paper is concerned with the determination of the kinetic parameters and the chemical reactions that characterize the passivation of ${P}_{b}$ centers with molecular hydrogen. ${P}_{b}$ centers are paramagnetic defects at the (111) Si-${\mathrm{SiO}}_{2}$ interface. In this study ${P}_{b}$ centers associated with thermal oxides grown on (111) silicon substrates at 850 \ifmmode^\circ\else\textdegree\fi{}C were measured with electron paramagnetic resonance. We observe that the ${P}_{b}$ resonance appears to be unaffected by subsequent in situ vacuum anneals for temperatures up to at least 850 \ifmmode^\circ\else\textdegree\fi{}C.The passivation of ${P}_{b}$ centers with ${\mathrm{H}}_{2}$ occurs for temperatures above approximately 220 \ifmmode^\circ\else\textdegree\fi{}C; dissociation of passivated centers in vacuum occurs for temperatures in excess of 550 \ifmmode^\circ\else\textdegree\fi{}C. The rate of passivation of ${P}_{b}$ centers with ${\mathrm{H}}_{2}$ is proportional to the ${\mathrm{H}}_{2}$ concentration and the density of ${P}_{b}$ centers at the interface and is characterized by the forward rate constant ${k}_{f}$. The temperature dependence of ${k}_{f}$ is observed to obey the Arrhenius equation and is characterized by an activation energy of 1.66\ifmmode\pm\else\textpm\fi{}0.06 eV and a preexponential factor, ${k}_{0f}$, of ${1.94}_{\mathrm{\ensuremath{-}}1.00}^{+2.00}$\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}6}$ ${\mathrm{cm}}^{3}$/sec. The rate equation for passivation of ${P}_{b}$ centers with ${\mathrm{H}}_{2}$ is consistent with a chemical process in which a hydrogen molecule reacts directly with a ${P}_{b}$ center. The rate at which this chemical reaction occurs is consistent with the diffusion of the ${\mathrm{H}}_{2}$ molecule among the accessible interstices of the ${\mathrm{SiO}}_{2}$ and the reaction site at ${P}_{b}$ centers. We also observe that the spin-lattice relaxation time, ${T}_{1}$, for ${P}_{b}$ centers at low temperatures (<100 K) increases with decreasing oxide thicknesses (800 A\r{}). ${T}_{1}$ also increases if the dry thermal oxides are annealed in ${\mathrm{H}}_{2}$ between 225 and 575 \ifmmode^\circ\else\textdegree\fi{}C or cooled in Ar gas after thermal oxidation.
On the role of nanocavities in suppressing boron transient enhanced diffusion and deactivation in F+ coimplanted silicon (2008)

An effective and process optimized method to suppress transient enhanced diffusion is proposed. The method presented consists of designing a vacancy-type defect region which effectively blocks the flux of interstitials from the end of range region towards the surface of the substrate. This band of vacancy-type defects is produced by high dose F+ coimplants. We provide a detailed microstructure study of the vacancy-type defect evolution and demonstrate that under optimum conditions, the vacancy-type defects effectively suppress transient enhanced diffusion, boron deactivation, and end of range defects. We also show the process conditions to obtain an effective interstitial barrier without introducing other detrimental diffusion effects.
Machine Vision Techniques for Somatic Coffee Embryo Morphological Feature Extraction (1994)

Machine vision algorithms were developed to examine somatic coffee embryo morphological features between maturation and germination stages. A skeleton morphological feature was extracted and recognition rules were established to identify Y shaped skeletons. An improved thinning algorithm was developed to obtain single-pixel-width skeletons that simplified the recognition task. The Y shaped skeleton was found to be a promising feature to represent torpedo stage embryo. For the 127 embryos tested, the success rate was 73% in identifying torpedo-stage somatic coffee embryos from the selected morphological feature.
Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems (2015)

Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurological applications. PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. However, there are several challenges to using PET imaging systems. These include the fundamental trade-offs between resolution and noise, the quantitative accuracy of the measurements, and integration with X-ray computed tomography and magnetic resonance imaging. In this article, we review how researchers and industry are addressing these challenges.
Square helical antenna with a dielectric core (1988)

The circuit and radiation characteristics of a helical antenna of square cross section with a dielectric core are studied. The effect of the core dielectric constant on the characteristics of one-, two-, and three-turn helices driven in the axial mode is examined. Comparisons between theory and measurement are included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Propofol depresses cisplatin cytotoxicity via the inhibition of gap junctions (2016)

The general anesthetic, propofol, affects chemotherapeutic activity, however, the mechanism underlying its effects remains to be fully elucidated. Our previous study showed that tramadol and flurbiprofen depressed the cytotoxicity of cisplatin via the inhibition of gap junction (GJ) intercellular communication (GJIC) in connexin (Cx)32 HeLa cells. The present study investigated whether the effects of propofol on the cytotoxicity of cisplatin were mediated by GJ in U87 glioma cells and Cx26‑transfected HeLa cells. Standard colony formation assay was used to determine the cytotoxicity of cisplatin. Parachute dye coupling assay was used to measure GJ function, and western blot analysis was used to determine the expression levels of Cx32. The results revealed that exposure of the U87 glioma cells and the Cx26-transfected HeLa cells to cisplatin for 1 h reduced clonogenic survival in low density cultures (without GJs) and high density cultures (with GJs). However, the toxic effect was higher in the high density culture. In addition, pretreatment of the cells with propofol significantly reduced cisplatin‑induced cytotoxicity, but only in the presence of functional GJs. Furthermore, propofol significantly inhibited dye coupling through junctional channels, and a long duration of exposure of the cells to propofol downregulated the expression levels of Cx43 and Cx26. These results demonstrated that the inhibition of GJIC by propofol affected the therapeutic efficacy of chemotherapeutic drugs. The present study provides evidence of a novel mechanism underlying the effects of analgesics in counteracting chemotherapeutic efficiency.
ACE: Automated capacity evaluation for HP ePrint (2013)

The HP cloud ePrint Service [1] allows customers to print from anywhere to an HP ePrint-enabled printer accessible via the Internet. As ePrint is a hosted service, it must provide customers with a high quality of service while keeping the costs of supporting the load as low as possible. The jobs entering the ePrint Service are diverse and complex in nature. The jobs vary largely in terms of their formats, sizes, originator clients, etc. With rapidly increasing growth in client requests, it has become imperative to understand the new service’s characteristics and the service dynamics over time in order to efficiently support and scale the ePrint System. With the complexity of offered cloud services increasing and application requirements for QoS growing, the research challenge is to design an integrated framework of measurements and system modeling to support performance
Differential Regulation of RasGAPs in Cancer (2011)

Ever since their discovery as cellular counterparts of viral oncogenes more than 25 years ago, much progress has been made in understanding the complex networks of signal transduction pathways activated by oncogenic Ras mutations in human cancers. The activity of Ras is regulated by nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), and much emphasis has been put into the biochemical and structural analysis of the Ras/GAP complex. The mechanisms by which GAPs catalyze Ras-GTP hydrolysis have been clarified and revealed that oncogenic Ras mutations confer resistance to GAPs and remain constitutively active. However, it is yet unclear how cells coordinate the large and divergent GAP protein family to promote Ras inactivation and ensure a certain biological response. Different domain arrangements in GAPs to create differential protein-protein and protein-lipid interactions are probably key factors determining the inactivation of the 3 Ras isoforms H-, K-, and N-Ras and their effector pathways. In recent years, in vitro as well as cell- and animal-based studies examining GAP activity, localization, interaction partners, and expression profiles have provided further insights into Ras inactivation and revealed characteristics of several GAPs to exert specific and distinct functions. This review aims to summarize knowledge on the cell biology of RasGAP proteins that potentially contributes to differential regulation of spatiotemporal Ras signaling.