gebhart/patrepeval huggingface dataset:
Matching of ground-based LiDAR and aerial image data for mobile robot localization in densely forested environments (2013)

We present a vision based method for the autonomous geolocation of ground vehicles and unmanned mobile robots in forested environments. The method provides an estimate of the global horizontal position of a vehicle strictly based on finding a geometric match between a map of observed tree stems, scanned in 3D by sensors onboard the vehicle, to another stem map generated from the structure of tree crowns observed in overhead imagery of the forest canopy. This method can be used in real-time as a complement to the Global Positioning System (GPS) in areas where signal coverage is inadequate due to attenuation by the forest canopy, or due to intentional denied access. The method presented in this paper has two key properties that are significant: i) It does not require a priori knowledge of the area surrounding the robot. ii) It uses the geometry of detected tree stems as the only input to determine horizontal geoposition.
β1 Integrins Modulate β-Adrenergic Receptor–Stimulated Cardiac Myocyte Apoptosis and Myocardial Remodeling (2007)

Sympathetic nerve activity increases in the heart during cardiac failure. Here, we hypothesized that beta1 integrins play a protective role in chronic beta-adrenergic receptor-stimulated cardiac myocyte apoptosis and heart failure. L-isoproterenol (iso; 400 microg/kg per hour) was infused in a group of wild-type (WT) and beta1 integrin heterozygous knockout (hKO) mice. Left ventricular structural and functional remodeling was studied at 7 and 28 days of iso-infusion. Western blot analysis demonstrated reduced beta1 integrin levels in the myocardium of hKO-sham. Iso-infusion increased heart weight:body weight ratios in both groups. However, the increase was significantly higher in WT-iso. M-mode echocardiography indicated increased left ventricular end-diastolic diameter, percentage of fractional shortening, and ejection fraction in the WT-iso group. The percentage of fractional shortening and ejection fraction were significantly lower in hKO-iso versus hKO-sham and WT-iso. Peak left ventricular developed pressure and left ventricular end-diastolic pressure measured using Langendorff-perfusion analyses were significantly higher in the WT-iso group (P<0.05 versus WT-sham and hKO-Iso). The number of TUNEL-positive myocytes was significantly higher in hKO-iso hearts 7 and 28 days after iso-infusion. The increase in myocyte cross-sectional area and fibrosis was higher in the WT-iso group. Matrix metalloproteinase-9 protein levels were significantly higher in WT-iso, whereas matrix metalloproteinase-2 levels were increased in hKO-iso hearts. Iso-infusion increased phosphorylation of c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 in both groups. The increase in c-Jun N-terminal kinase phosphorylation was significantly higher in hKO-iso (P<0.001 versus WT-iso). Thus, beta1 integrins play a crucial role in beta-adrenergic receptor-stimulated myocardial remodeling with effects on cardiac myocyte hypertrophy, apoptosis, and left ventricular function.
Stimulated echo diffusion tensor imaging (STEAM-DTI) with varying diffusion times as a probe of breast tissue (2016)

2 J. Magn. Reson. Imaging 2017;45:84-93.
REVIEWS OF BOOKS (1988)

REVIEWS OF BOOKS FOCUS ON CHEMONUCLEOLYSIS. Edited by Jean-Francois Bonneville. Pp. 153. DM 124,¯. Berlin, Heidelberg, New York: Springer-Verlag. 1986. J. MATHEWS J. MATHEWS Search for other works by this author on: Oxford Academic PubMed Google Scholar Rheumatology, Volume 27, Issue 2, April 1988, Page 168, https://doi.org/10.1093/rheumatology/27.2.168-a Published: 01 April 1988
Identification and characterization of an aspartyl protease from <i>Cryptococcus neoformans</i> (2007)

Cryptococcosis, caused by Cryptococcus neoformans, is an invasive infection often occurring in AIDS patients. Potent therapy against HIV, which includes protease inhibitors (PIs), has beneficial effects also on opportunistic infections by pathogens such as C. neoformans and C. albicans. PIs inhibit growth of C. albicans by affecting the activity of its aspartyl proteases. We identified, cloned and sequenced a cDNA from C. neoformans encoding for a putative aspartyl protease (CnAP1), and the corresponding genomic region. The gene cnap1 codifies for a protein of 505 aa, with a canonical aspartyl protease structure. We purified the recombinant protein and analyzed its activity in the presence of PIs (Indinavir, Lopinavir, Ritonavir), but did not evidence any inhibition of protease activity. The transcriptional level of cnap1 in C. neoformans is constant in different media. The absence of any inhibition activity by PIs suggests that other targets for PIs might exist in C. neoformans.
1/f Noise and DC Characterization of Partially Depleted SOI N-and P-MOSFETs from 20 &amp;#186; C-250 &amp;#186; C (2005)

A summary of measured small-signal parameters and low frequency noise characterized over temperature is presented for N- and P- MOSFETs fabricated in a partially depleted SOI 0.8 mum process. Small-signal dc parameters critical in analog circuit design are reported including device transconductance efficiency (g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> /I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> ), output resistance (r <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ds</sub> ), and threshold voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> ). These parameters are summarized as a function of both gate length (0.8mum, 2.0mum, 5.0mum, and 20mum) and temperature (20deg to 300degC). Noise characterization of these devices is also presented with an emphasis on flicker noise over temperature (20deg to 250degC). Data is presented in terms of both drain current and inversion coefficient, where appropriate. Use of this information provides the designer with an excellent tool for estimating analog circuit performance in applications where wide temperature range performance is required
Design of a Planar Slotted Waveguide Array Antenna for X-band Radar Applications (2011)

A planar slotted waveguide array antenna has been designed at 9.37 GHz for X-band radar applications. The antenna consists of multiple branchline waveguides with broadwall radiating shunt slots and a main waveguide to feed the branch waveguides through a series of inclined coupling slots. The antenna feed point is located at the center of the main waveguide. Element weights in the array have been calculated bysampling a continuous circular Taylor aperture distribution at the 25 dB sidelobe level in both the E and Hplanes. A commercially available electromagnetic (EM) simulation tool has been used to characterize the individual isolated slot and that data hassubsequently been used to design the planar array. The array is finally analyzed in a CST Microwave studio and the measured and simulated results have been found to be in good agreement.
Internally applied endotoxin and the activation of BK channels in cerebral artery smooth muscle via a nitric oxide‐like pathway (1998)

1. In this study the role of nitric oxide synthase (NOS) in the acute activation of large conductance, Ca2+-activated K+ channels (BK channels) by internally applied E. coli lipopolysaccharide (LPS, endotoxin) was examined in vascular smooth muscle cells. 2. Cerebrovascular smooth muscle cells (CVSMCs) were enzymatically dispersed from the middle, posterior communicating and posterior cerebral arteries of adult Wistar rats and maintained at 4 degrees C for 2-4 days before recording with standard patch-clamp techniques. 3. Acute application of LPS (100 microg ml(-1)) to inside-out patches of CVSMC membrane isolated in a cell-free environment rapidly and reversibly increased the open probability, Po of BK channels in these patches by 3.3+/-0.30 fold. 4. Acute application of the nitric oxide (NO) donor sodium nitroprusside (SNP, 100 microM) to inside-out patches of CVSMC membrane, studied in the presence of intact cells, also reversibly increased Po, by some 1.8+/-0.2 fold over control. 5. Kinetic analysis showed that both LPS and SNP increased Po by accelerating the rate of BK channel reopening, rather than by retarding the closure of open channels. 6. Neither LPS nor SNP altered the reversal potential or conductance of BK channels. 7. The NOS substrate L-arginine (1 microM) potentiated the acute activation of BK channels by LPS, while the synthetic enantiomer D-arginine (1 microM) inhibited the action of LPS on BK channels. 8. The acute activation of BK channels by LPS was suppressed by pre-incubation of cells with N(omega)-nitro-L-arginine (50 microM) or N(omega)-nitro-L-arginine methyl ester (1 mM), two competitive antagonists of nitric oxide synthases. N(omega)-nitro-D-arginine (50 microM), a poor inhibitor of NOS in in vitro assays, had no effect on BK channel activation by LPS. 9. These results indicate that excised, inside-out patches of CVSMC membrane exhibit a NOS-like activity which is acutely activated when LPS is present at the cytoplasmic membrane surface. Possible relationships between this novel mechanism and the properties of known isoforms of nitric oxide synthase are discussed.
Rollover Simulation Based on a Nonlinear Model (1998)

<div class="htmlview paragraph">Research has shown, that accidents involving rollover represent a great safety threat to the passengers. In order to develop restraint systems, a rollover detection mechanism has to be found. Since real world rollover tests are very expensive and difficult to reproduce, a computer simulation of the rollover sequence is very helpful.</div> <div class="htmlview paragraph">This paper presents a multi body rollover model, which was designed to investigate the process of rollover. The model was chosen as simple as possible to allow for short simulation times but still preserve all the important influences.</div> <div class="htmlview paragraph">The model investigates the results of an impact, where the vehicle slides laterally into a rigid barrier with different velocities. Also the influence of different vehicle parameters like the position of the center of gravity on the rollover stability are investigated.</div> <div class="htmlview paragraph">A special focus is put on the suspension system of the vehicle, as it has a major influence on the rollover sequence. An accurate, nonlinear approach was necessary to produce satisfying simulation results. The nonlinearities occur due to geometric constraints. Nonlinearities in spring and damper elements were neglected.</div> <div class="htmlview paragraph">In order to avoid a very complex impact model which would have to describe the plastic and elastic deformations at the tires, a different approach was chosen. Instead of explicitly calculating the acting forces, the linear and angular moments right after the impact was derived, whereas the impact was considered to be a very short impulse.</div>
Sequential multistep energy transfer: enhancement of efficiency of long-range fluorescence resonance energy transfer (1999)

The efficiency of long-range (ca. 80 Å) fluorescence energy transfer was enhanced about 1.5 times by a third chromophore located midway between two chromophores, which suggests sequential multistep energy transfer across the three chromophores.
Large-area 2D periodic crystalline silicon nanodome arrays on nanoimprinted glass exhibiting photonic band structure effects (2012)

Two-dimensional silicon nanodome arrays are prepared on large areas up to 50 cm² exhibiting photonic band structure effects in the near-infrared and visible wavelength region by downscaling a recently developed fabrication method based on nanoimprint-patterned glass, high-rate electron-beam evaporation of silicon, self-organized solid phase crystallization and wet-chemical etching. The silicon nanodomes, arranged in square lattice geometry with 300 nm lattice constant, are optically characterized by angular resolved reflection measurements, allowing the partial determination of the photonic band structure. This experimentally determined band structure agrees well with the outcome of three-dimensional optical finite-element simulations. A 16% photonic bandgap is predicted for an optimized geometry of the silicon nanodome arrays. By variation of the duration of the selective etching step, the geometry as well as the optical properties of the periodic silicon nanodome arrays can be controlled systematically.
Traditional and Advanced Cell Cultures in Hematopoietic Stem Cell Studies (2019)

Hematopoiesis is the main function of bone marrow. Human hematopoietic stem and progenitor cells reside in the bone marrow microenvironment, making it a hotspot for the development of hematopoietic diseases. Numerous alterations that correspond to disease progression have been identified in the bone marrow stem cell niche. Complex interactions between the bone marrow microenvironment and hematopoietic stem cells determine the balance between the proliferation, differentiation and homeostasis of the stem cell compartment. Changes in this tightly regulated network can provoke malignant transformation. However, our understanding of human hematopoiesis and the associated niche biology remains limited due to accessibility to human material and the limits of in vitro culture models. Traditional culture systems for human hematopoietic studies lack microenvironment niches, spatial marrow gradients, and dense cellularity, rendering them incapable of effectively translating marrow physiology ex vivo. This review will discuss the importance of 2D and 3D culture as a physiologically relevant system for understanding normal and abnormal hematopoiesis.
An in vitro cytotoxicity study of aldehyde-treated pig dermal collagen. (1983)

The cytotoxicity of aldehyde-treated collagen was assayed by measuring 3H-thymidine incorporation in adult human skin fibroblasts grown in tissue culture for 1 or 3 days in the presence of pig dermal collagen cross-linked with formaldehyde or glutaraldehyde. A comparison was also made with collagen preparations washed for 2 weeks either at 15 degrees throughout or partly at 15 degrees and partly at 37 degrees. Collagen treated with both formaldehyde and glutaraldehyde proved increasingly toxic with increase in the concentrations of aldehyde used. While the maximum toxic effect was observed after 1 day culture in formaldehyde-treated collagen, with thymidine uptake ranging from 4-48% of control values with 5-0.1% formaldehyde and a 15 degrees wash, the toxic effect of glutaraldehyde treatment increased with longer exposure and at 3 days thymidine uptake ranged from 3-40% of control values with 0.05-0.001% glutaraldehyde and washing at 15 degrees. Washing partly at 37 degrees significantly reduced toxicity, the differences in thymidine uptake as compared with washing at 15 degrees alone ranging from 34-50% with 1 and 0.3% formaldehyde respectively in 1 day cultures and from 14-37% with 0.02 and 0.005% glutaraldehyde in 3 day cultures. While fibroblasts actively grew and migrated when seeded on non-cross-linked collagen, only limited cell survival occurred on aldehyde-treated collagen.
The interdependence of antibody C and V regions on specificity and affinity (2013)

This article refers to:Constant domains influence binding of mouse–human chimeric antibodies to the capsular polypeptide of Bacillus anthracis
The structure of metallo-supramolecular polyelectrolytes in solution and on surfaces (2010)

Metal ion induced self-assembly of the rigid ligand 1,4-bis(2,2′:6′,2″-terpyridine-4′-yl)benzene (1) with Fe(II), Co(II), Ni(II) and Zn(II) acetate in aqueous solution results in extended, rigid-rod like metallosupramolecular coordination polyelectrolytes (MEPE-1). Under the current experimental conditions the molar masses range from 1000 g mol−1 up to 500 000 g mol−1. The molar mass depends on concentration, stoichiometry, metal-ion and time. In addition, we present viscosity measurements, small angle neutron scattering and AFM data. We introduce a protocol to precisely control the stoichiometry during self-assembly using conductometry. The protocol can be used with different terpyridine ligands and the above-mentioned metal ions and is of paramount importance to obtain meaningful and reproducible results. As a control experiment we studied the mononuclear 4′-(phenyl)-2,2′:6′,2″-terpyridine (3) complex with Ni(II) and Zn(II) and the flexible ligand 1,3-bis[4′-oxa(2,2′:6′,2″-terpyridinyl)]propane (2) with Ni(II) acetate (Ni-MEPE-2). This ligand does not form extended macro-assemblies but likely ring-like structures with 3 to 4 repeat units. Through spin-coating of Ni-MEPE-1 on a solid surface we can image the MEPEs in real space by AFM. SANS measurements of Fe-MEPE-1 verify the extended rigid-rod type structure of the MEPEs in aqueous solution.
Performance trending for management of high-speed packet-switched networks (2002)

Due to technological advances, computer communication networks are becoming increasingly complex. In addition, applications require networks to provide high performance and reliability. Placing such demands on these networks necessitates an efficient network management. Many existing systems perform data collection and reporting only, and so operators must use their own expertise to do aid the trouble shooting. To provide a dynamic solution, it is necessary to provide a real-time automated control of network operation parameters. The objective of this research is to develop and demonstrate the capability of applying modeling and simulation techniques to maintain the network integrity of a high-speed packet-switched network. In the paper a new technique called performance trending is presented, in which key network parameters are monitored and network failure is predicted. Performance trending is also used for the network performance maintenance by means of analysis and tuning to predict and prevent network failures. A typical packet-switched network is simulated to verify the performance trending for network performance management. End-to-end delay and bit error rate (BER) are used to illustrate performance trending and their effects on the network performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Radiation Dose Reduction in Chest CT: A Review (2008)

A variety of methods and techniques for radiation dose reduction should be used to ensure that radiation exposure is kept as low as is reasonably achievable.
Fiber-optic magnesium and calcium ion sensor based on a natural carboxylic polyether antibiotic (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFiber-optic magnesium and calcium ion sensor based on a natural carboxylic polyether antibioticKoji. Suzuki, Koji. Tohda, Yasushi. Tanda, Hiroshi. Ohzora, Shuji. Nishihama, Hidenari. Inoue, and Tsuneo. ShiraiCite this: Anal. Chem. 1989, 61, 4, 382–384Publication Date (Print):February 15, 1989Publication History Published online1 May 2002Published inissue 15 February 1989https://pubs.acs.org/doi/10.1021/ac00179a018https://doi.org/10.1021/ac00179a018research-articleACS PublicationsRequest reuse permissionsArticle Views306Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nicotinamide Adenine Dinucleotide Phosphate-Dependent Formate Dehydrogenase from <i>Clostridium thermoaceticum:</i> Purification and Properties (1974)

The nicotinamide adenine dinucleotide phosphate (NADP)-dependent formate dehydrogenase in Clostridium thermoaceticum used, in addition to its natural electron acceptor, methyl and benzyl viologen. The enzyme was purified to a specific activity of 34 (micromoles per minute per milligram of protein) with NADP as electron acceptor. Disc gel electrophoresis of the purified enzyme yielded two major and two minor protein bands, and during centrifugation in sucrose gradients two components of apparent molecular weights of 270,000 and 320,000 were obtained, both having formate dehydrogenase activity. The enzyme preparation catalyzed the reduction of riboflavine 5'-phosphate flavine adenine dinucleotide and methyl viologen by using reduced NADP as a source of electrons. It also had reduced NADP oxidase activity. The enzyme was strongly inhibited by cyanide and ethylenediaminetetraacetic acid. It was also inhibited by hypophosphite, an inhibition that was reversed by formate. Sulfite inhibited the activity with NADP but not with methyl viologen as acceptor. The apparent K(m) at 55 C and pH 7.5 for formate was 2.27 x 10(-4) M with NADP and 0.83 x 10(-4) with methyl viologen as acceptor. The apparent K(m) for NADP was 1.09 x 10(-4) M and for methyl viologen was 2.35 x 10(-3) M. NADP showed substrate inhibition at 5 x 10(-3) M and higher concentrations. With NADP as electron acceptor, the enzyme had a broad pH optimum between 7 and 9.5. The apparent temperature optimum was 85 C. In the absence of substrates, the enzyme was stable at 70 C but was rapidly inactivated at temperatures above 73 C. The enzyme was very sensitive to oxygen but was stabilized by thiol-iron complexes and formate.
Effect of Heat on Raw Rubber (1928)

Abstract A study has been made of the effect of heat upon crude rubber. Heating in steam for 24 hours at 158° C. plastifies the rubber to about the same extent as about five passes through a tight mill. The chemical characteristics are changed in such a way as to indicate that a portion of the protein materials and fatty acid esters has been hydrolyzed. The rate of cure is increased in the case of most crudes for mercaptobenzothiazole and pure-gum mixes, but is less affected in the case of hexamethylenetetramine, diphenylguanidine, and ethylidene aniline. The stress-strain curve is affected by the heating in such a way as to make it more convex toward the strain axis. A study has been made of the chemical constituents of the heated rubber which have been responsible for changes in curing characteristics. It is believed that the amines, nitrogen bases, and alkaloids are the principal active material responsible for the peculiarities of heated rubber.
Theoretical Investigation of the Negative Hydrogen Molecule Ion (1959)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Inga Fischer‐Hjalmars; Theoretical Investigation of the Negative Hydrogen Molecule Ion. J. Chem. Phys. 1 April 1959; 30 (4): 1099. https://doi.org/10.1063/1.1730090 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioThe Journal of Chemical Physics Search Advanced Search |Citation Search