gebhart/patrepeval huggingface dataset:
Dry Eye Reversal and Corneal Sensation Restoration With Topical Naltrexone in Diabetes Mellitus (2009)

Topical application of NTX to the ocular surface may serve as an important strategy for treating dry eye and corneal anesthesia in diabetes. Its effect, if any, in other forms of decreased corneal sensitivity and/or dry eye should be investigated.
Generation and detection of high-order harmonics in liquids using a scanning acoustic microscope (1988)

The nonlinear generation of harmonics by high-power focused acoustic beams in liquids has been investigated. A transmission mode acoustic microscope using focal plane detection has been used for high-harmonic signal sensitivity. Detection of up to the 14th harmonic in ethanol has been achieved at an emission frequency of 15 MHz. Measurements show that signal in all harmonics tends to saturate at a very high emitted power. At lower power, harmonics varied as Pn1, where P1 is the emitted power and n the harmonic number. Resolution improvement of the acoustic microscope by receiving at harmonic signals has also been demonstrated. The resolution has been shown to increase as (n)1/2 for reception at the nth harmonic, in good agreement with focused Gaussian beam theory. A nonlinear resolution improvement by a factor of 3 has been obtained.
Combining Vertex-Centric Graph Processing with SPARQL for Large-Scale RDF Data Analytics (2017)

Modern applications require sophisticated analytics on RDF graphs that combine structural queries with generic graph computations. Existing systems support either declarative SPARQL queries, or generic graph processing, but not both. We bridge the gap by introducing Spartex, a versatile framework for complex RDF analytics. Spartex extends SPARQL to combine seamlessly generic graph algorithms (e.g., PageRank, Shortest Paths, etc.) with SPARQL queries. Spartex builds on existing vertex-centric graph processing frameworks, such as Graphlab or Pregel. It implements a generic SPARQL operator as a vertex-centric program that interprets SPARQL queries and executes them efficiently using a built-in optimizer. In addition, any graph algorithm implemented in the underlying vertex-centric framework, can be executed in Spartex. We present various scenarios where our framework simplifies significantly the implementation of complex RDF data analytics programs. We demonstrate that Spartex scales to datasets with billions of edges, and show that our core SPARQL engine is at least as fast as the state-of-the-art specialized RDF engines. For complex analytical tasks that combine generic graph processing with SPARQL, Spartex is at least an order of magnitude faster than existing alternatives.
Surface-Enhanced Raman Spectroscopy as a Tool for Probing Specific Biochemical Components in Bacteria (2004)

Treatment of bacteria with silver yields intense and highly specific surface-enhanced Raman spectroscopy (SERS) spectra from various cellular chemical components located in the vicinity of the silver colloids. In particular, we demonstrate an extreme sensitivity to flavin components associated with the cell envelope and to their state of oxidation. Different spectra, possibly associated with DNA, carboxylates, and perhaps phosphates, are obtained from the soluble interior fraction of the cell.
Metabolism of indium chelates attached to monoclonal antibody: minimal transchelation of indium from benzyl-EDTA chelate in vivo. (1990)

The metabolism of radiolabeled antibodies is important for radioimmunoimaging and therapy. The loss of indium-111 (111In) from the chelate can pose problems in imaging and increases the radiation dose to normal tissues. We have evaluated the loss in vivo of 111In from Lym-1-benzyl-EDTA-111In (an antibody conjugated with isothiocyanato-benzyl-EDTA) in normal mice. A monoclonal antibody (CHA 255) that binds to benzyl-EDTA-indium chelates, but not to other forms of indium, was used to measure the percent of 111In remaining in the chelate. Four days after injection, 97.4 +/- 2.2% of the 111In in the liver was still in the benzyl-EDTA chelate, as was 99.4 +/- 0.7% of the 111In in the urine, and 99.1 +/- 0.7% of the 111In in the blood. Studies in vitro indicate that a benzyl-EDTA-111In-antibody-chelate conjugate is more stable in human serum than a benzyl-DTPA-111In conjugate, and that both benzyl-chelate conjugates are much more stable than an unsubstituted DTPA conjugate.
Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model (1993)

C57BL/6J mice given low doses of lipopolysaccharide (LPS) (100 ng per mouse) plus D-galactosamine (8 mg per mouse) die within 24 h following LPS administration. We used this septic shock model to confirm the role of tumor necrosis factor in mortality using a monoclonal antibody to tumor necrosis factor to prevent lethality. Furthermore, we demonstrated that interleukin 6, rather than playing a lethal role, protected mice against death in this septic shock model. Antibody to interleukin 6 did not affect the fatal outcome in this low-LPS-dose model. However, pretreatment with antibody to tumor necrosis factor did protect the mice against death, in a dose-dependent manner. Moreover, mortality was enhanced by pretreatment with antibody to interleukin 6 when tumor necrosis factor was partly limited by anti-tumor necrosis factor treatment. Mortality was significantly reduced by pretreatment with both recombinant interleukin 6 and low doses of antibody to tumor necrosis factor; in the absence of the low dose of antibody to tumor necrosis factor, interleukin 6 alone did not confer any protection. These data demonstrate in vivo antagonistic activities of tumor necrosis factor and interleukin 6 and show that interleukin 6 can play a protective role against death from septic shock.
Electrochemistry and spectroscopy of dicyanobis(phenanthroline)iron, tetracarbonyltetrakis(cyclopentadienyl)tetrairon and dicarbonylcyano(cyclopentadienyl)iron in an acidic molten salt (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemistry and spectroscopy of dicyanobis(phenanthroline)iron, tetracarbonyltetrakis(cyclopentadienyl)tetrairon and dicarbonylcyano(cyclopentadienyl)iron in an acidic molten saltCarrie Woodcock and Duward F. ShriverCite this: Inorg. Chem. 1986, 25, 13, 2137–2142Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://doi.org/10.1021/ic00233a008RIGHTS & PERMISSIONSArticle Views133Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (778 KB) Get e-Alerts Get e-Alerts
Augmentation of Left Ventricular Mechanics by Recirculation-Mediated AAV2/1–SERCA2a Gene Delivery in Experimental Heart Failure (2011)

In a large animal model, AAV2/1-mediated SERCA2a gene delivery using percutaneous, recirculating cardiac delivery leads to improved LV function.
Ultra-Short Pulses for Optical Soliton Transmission. New Approach from External Modulation. (1992)

Mode-locking and gain-switching of semiconductor lasers have been reviewed from a view point of an optical short pulse generator for soliton transmission. A new approach from an external modulation using an electroabsorption modulator to generation of transform-limited optical short pulses is demonstrated. Transform-limited optical pulses up to 20 GHz repetition rates were generated just using a sinusoidal modulation of an InGaAsP electroabsorption modulator without any optical resonators and optical filters. The shape of the modulator-generated pulse is very closed to sech2 shape, and both the pulse width and the repetition rate can be easily varied by electrical signals. The promising future of the simple and stable optical pulse generation using the electroabsorption modulator was confirmed by 2.5 Gb/s-6400 km soliton data transmission using circulating loop experiments.
Glutathione and Glutathione Delivery Compounds (1996)

Deficiency of GSH (BSO model) demonstrates the need for cellular protection from endogenous ROS. The pathology of various diseases is often associated with ROS and oxidative stress. The several methods for modulating cellular GSH levels presented in this chapter offer selective tools to study mechanisms and offer potential therapy of human diseases associated with GSH deficiency and oxidative stress.
Dose-related vestibular and cochlear effects of transtympanic gentamicin. (1998)

Our results suggest that in the gerbil, gentamicin is ototoxic but not selectively vestibulotoxic. In general, increasing the number of transtympanic injections increases the damage to sensory hair cells in both the posterior crista and the cochlea. A variation in interanimal susceptibility to ototoxic effects exists, but the amount of damage is consistent in both cochlear and vestibular hair cells from the same animal.
Guiding accessibility issues in the design of websites (2008)

Including accessibility in the design of Websites 1.0 entails difficulties, but this situation becomes more complicated when the user becomes a creator in the web. There are new requirements to be considered in the design due to the user's active interaction in the web 2.0 environment, such as the web pages with user-generated content (like Blogs), where there are not only information receptors, but issuers as well,. This paper offers a solution for including accessibility requirements in the design process based on using accessible content templates in order to preserve accessibility and the editing process using models and rules to annotate structure and semantics of contents. This annotation is added to the final codification, which will guarantee a better complement to the standards and accessibility guidelines.
Nucleotide sequence of the<i>aroP</i>gene encoding the general aromatic amino acid transport protein of<i>Escherichia coli</i>K-12: homology with yeast transport proteins (1990)

Journal Article Nucleotide sequence of the aroP gene encoding the general aromatic amino acid transport protein of Escherichia coli K-12: homology with yeast transport proteins Get access Nadine Honoré, Nadine Honoré Laboratoire de Génétique Moleculaire Bactérienne, Institut Pasteur28 rue du Docteur Roux, 75724 Paris Cedex 15, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Stewart T. Cole Stewart T. Cole * Laboratoire de Génétique Moleculaire Bactérienne, Institut Pasteur28 rue du Docteur Roux, 75724 Paris Cedex 15, France * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 3, 11 February 1990, Page 653, https://doi.org/10.1093/nar/18.3.653 Published: 11 February 1990 Article history Accepted: 09 January 1990 Published: 11 February 1990
Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas (2007)

The current findings suggested that EGFR expression correlates with poor prognostic factors and may be used to predict patient outcomes.
Busulfan bioavailability (1994)

Busulfan is widely used as a component of the myeloablative therapy in bone marrow transplantation. Recent studies have shown that the drug disposition is altered in children and is associated with less therapeutic effectiveness, lower toxicities, and higher rates of engraftment failure. We have evaluated the bioavailability of the drug in two groups of patients: eight children between 1.5 and 6 years of age and eight older children and adults between 13 and 60 years. Oral bioavailability showed a large interindividual variation. In children, the bioavailability ranged from 0.22 to 1.20, and for adults, it was within the range 0.47 to 1.03. The elimination half-life after intravenous administration in children (2.46 +/- 0.27 hours; mean +/- SD) did not differ from that obtained for adults (2.61 +/- 0.62 hours). However, busulfan clearance normalized to body weight was significantly higher in children (3.62 +/- 0.78 mL.min-1.kg-1) than that in adults (2.49 +/- 0.52 mL.min-1.kg-1). Also, the distribution volume normalized for body weight was significantly higher in children (0.74 +/- 0.10 L.kg-1) compared with 0.56 +/- 0.10 L. kg-1 in adults. The difference in clearance between children and adults was not statistically significant when normalized to body surface area, which most probably shows that busulfan dosage should be calculated on the basis of surface area rather than body weight. However, to avoid drug-related toxicities, drug monitoring and an individual dose adjustment should be considered because of the variability in busulfan bioavailability.
Integration of Amplified Differential Gene Expression (ADGE) and DNA Microarray (2002)

Amplified Differential Gene Expression (ADGE) provides a new concept that the ratios of differentially expressed genes are magnified before detection in order to improve both sensitivity and accuracy. This technology is now implemented with integration of DNA reassociation and PCR. The ADGE technique can be used either as a stand-alone method or in series with DNA microarray. ADGE is used in sample preprocessing and DNA microarray is used as a displaying system in the series combination. These two techniques are mutually synergistic: the quadratic magnification of ratios of differential gene expression achieved by ADGE improves the detection sensitivity and accuracy; the PCR amplification of templates enhances the signal intensity and reduces the requirement for large amounts of starting material; the high throughput for DNA microarray is maintained.
Randomized phase II clinical trial of avotermin <i>versus</i> placebo for scar improvement (2011)

Avotermin 500 ng per 100 µl per linear cm of wound margin given once is well tolerated and significantly improves scar appearance.
Channel coding for wireless communication via electromagnetic polarization (2016)

This paper investigates fundamental properties of polarization-based modulation for wireless communication - and in particular the application of channel coding techniques to such systems. After developing appropriate channel models, bounds on achievable rates are computed, and the performance of exemplary LDPC codes are simulated; this is done for both additive white Gaussian noise channels as well as channels subject to i.i.d. Rayleigh fading. A novel “on/off” modulation scheme is developed that adaptively changes the information-bearing polarization states based on the singular value decomposition (SVD) of the realized channel; this scheme is shown to significantly outperform fixed-constellation schemes as well as adaptive-constellation schemes employing equal energy signals.
Effect of intravenous polyunsaturated phosphatidylcholine infusion on insulin receptor processing and lipid composition of erythrocytes in patients with liver cirrhosis (1992)

The aim of this study was to determine whether insulin receptor processing capabilities of human erythrocytes could be improved by changing the cell membrane lipid composition using an intravenous infusion of polyunsaturated phosphatidylcholine. Thirteen cirrhotics were submitted to the i.v. infusion of phosphatidylcholine (2 g day-1 for 3 days). Both erythrocyte lipid composition and insulin receptor processing ability were examined at the beginning of the study and at 0, 3 and 11 days after the end of the treatment. This treatment decreased the erythrocyte cholesterol to phospholipid molar ratio and increased the proportion of polyunsaturated fatty acids (mainly linoleic acid) immediately after the end of the treatment. The proportion of arachidonic acid increased immediately in the phosphatidylserine class and, a few days later, also in phosphatidylethanolamine. The phospholipid class distribution did not show any relevant modification in the course of the study. Surface insulin receptors, which generally were up-regulated in the untreated subject (-7.1 +/- 20.4%), showed an improvement in down regulation capabilities that appeared to be well correlated with the changes in lipid composition of cell membranes induced by i.v. infusion of polyunsaturated phosphatidylcholine. The confirmation of these findings also in target cells for insulin may open new perspectives in the treatment of diabetes mellitus.
Phosphorylation of the InaD Gene Product, a Photoreceptor Membrane Protein Required for Recovery of Visual Excitation (1996)

In an approach directed to isolate and characterize key proteins of the transduction cascade in photoreceptors using the phosphoinositide signaling pathway, we have isolated the Calliphora homolog of the Drosophila InaD gene product, which in Drosophila InaD mutants causes slow deactivation of the light response. By screening a retinal cDNA library with antibodies directed against photoreceptor membrane proteins, we have isolated a cDNA coding for an amino acid sequence of 665 residues (Mr = 73,349). The sequence displays 65.3% identity (77.3% similarity) with the Drosophila InaD gene product. Probing Western blots with monospecific antibodies directed against peptides comprising amino acids 272-542 (anti-InaD-(272-542)) or amino acids 643-655 (anti-InaD-(643-655)) of the InaD gene product revealed that the Calliphora InaD protein is specifically associated with the signal-transducing rhabdomeral photoreceptor membrane from which it can be extracted by high salt buffer containing 1.5 M NaCl. As five out of eight consensus sequences for protein kinase C phosphorylation reside within stretches of 10-16 amino acids that are identical in the Drosophila and Calliphora InaD protein, the InaD gene product is likely to be a target of protein kinase C. Phosphorylation studies with isolated rhabdomeral photoreceptor membranes followed by InaD immunoprecipitation revealed that the InaD protein is a phosphoprotein. In vitro phosphorylation is, at least to some extent, Ca 2+ dependent and activated by phorbol 12-myristate 13-acetate. The inaC-encoded eye-specific form of a protein kinase C (eye-PKC) is co-precipitated by antibodies specific for the InaD protein from detergent extracts of rhabdomeral photoreceptor membranes, suggesting that the InaD protein and eye-PKC are interacting in these membranes. Co-precipitating with the InaD protein and eye-PKC are two other key components of the transduction pathway, namely the trp protein, which is proposed to form a Ca2+ channel, and the norpA-encoded phospholipase C, the primary target enzyme of the transduction pathway. It is proposed that the rise of the intracellular Ca2+ concentration upon visual excitation initiates the phosphorylation of the InaD protein by eye-PKC and thereby modulates its function in the control of the light response.
Metabolism of 26‐[<sup>14</sup>C]hydroxyecdysone 26‐phosphate in the tobacco hornworm, <i>Manduca sexta</i> L., to a new ecdysteroid conjugate: 26‐[<sup>14</sup>C]hydroxyecdysone 22‐glucoside (1987)

Abstract Following injection into female Manduca sexta pupae, [ 14 C]cholesterol is converted to a radiolabeled C 21 nonecdysteroid conjugate as well as ecdysteroid conjugates, which in ovaries and newly‐laid eggs consist mainly of labeled 26‐hydroxyecdysone 26‐phosphate. During embryogenesis, as the level of 26‐hydroxyecdysone 26‐phosphate decreases there is a concurrent increase in the amount of a new, labeled ecdysteroid conjugate. This conjugate, which is the major ecdysteroid conjugate (9.4 μg/g) in 0‐ to 1‐hour‐old larvae was identified as 26‐hydroxyecdysone 22‐glucoside by nuclear magnetic resonance and chemical ionization mass spectrometry. This is the first ecdysteroid glucoside to be identified from an insect. The disappearance of 26‐hydroxyecdysone 26‐phosphate in 0‐ to 1‐hour‐old larvae indicates that the 26‐hydroxyecdysone 22‐glucoside is derived from 26‐hydroxyecdysone 26‐phosphate. 3‐Epi‐26‐hydroxyecdysone was the major free ecdysteroid isolated from these larvae and 3‐epi‐20,26‐dihydroxyecdysone was the next most abundant ecdysteroid isolated. Interestingly, the 0‐ to 1‐hour‐old larvae contained the highest levels of 3α‐ecdysteroids per gram of insect tissue (8.7 μg/g) to be isolated from an insect, yet there was a complete absence of the corresponding free 3β‐epimers. The ecdysteroid conjugate profiles of ovaries and 0‐ to 1‐hour‐old larvae are discussed. Methodology is presented that permits the efficient separation of free and conjugated ecdysteroids and nonecdysteroid conjugates (C 21 ‐steroid conjugates).
Targeting the Notch signaling pathway in cancer stem cells (2009)

Stem cells are characterized by two unique properties: self-renewal and multilineage differentiation potential. Self-renewal provides the cell with the ability to go through numerous cycles of cell division, while maintaining a stem cell population through asymmetric cell division. For each division, a stem cell divides into two cells: another stem cell and a progenitor cell. It is thought that the stem cell retains the stem cell characteristics, while the progenitor cell can differentiate into tissue-specific cells within a limited number of cell divisions. Embryonic stem cells are active during embryonic differentiation and develop into all of the tissues in the body. Adult stem cells can be found in differentiated tissues and can differentiate into the entirety of cell types in the tissue from which they originate. Normal stem cells are transformed into cancer stem cells by acquiring somatic mutations in oncogenes or tumor suppressor genes. Cancer stem cells share stem cell properties with embryonic stem cells such as self-renewal and differentiation potential. Evidence suggests that many cancers, including leukemia, breast cancer, and glioma, contain a rare population of cells that are highly tumorigenic, in contrast to the bulk of cancer cells that have a limited capacity to form tumors in vivo. Cancer stem cells proliferate slowly, have indefinite self-replication ability, and are highly resistant to chemotherapy.
1-Phenylborabenzene anion (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-Phenylborabenzene anionArthur J. Ashe III and Paul ShuCite this: J. Am. Chem. Soc. 1971, 93, 7, 1804–1805Publication Date (Print):April 1, 1971Publication History Published online1 May 2002Published inissue 1 April 1971https://pubs.acs.org/doi/10.1021/ja00736a052https://doi.org/10.1021/ja00736a052research-articleACS PublicationsRequest reuse permissionsArticle Views871Altmetric-Citations206LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts