gebhart/patrepeval huggingface dataset:
The fundamental concepts of robust compliant motion for robot manipulators (1986)

Manipulators are subject to interaction forces when they maneuver in a constrained work-space. Our goal is to develop a method for the design of controllers or constrained manipulators in the presence of model, uncertainties. The controller must carry out fine maneuvers when the manipulator is not constrained, and compliant motion, with or without Interaction-force measurement, when the manipulator is constrained. At the same time stability must be preserved If bounded uncertainties are allowed in modelling the manipulators. Stability of the manipulator and environment as a whole and the preservation of stability in the face of changes are two fundamental, issues that have been considered in the design method. We start with conventional controller design specifications concerning the treatment of external forces when the manipulator is not constrained. Generalizing this concept to include cases when the manipulator is constrained, we state a set of practical, design specifications in the frequency domain that is meaningful, from the standpoint of control, theory and assures the desired compliant motion. In the cartesian coordinate frame and stability in the presence of bounded uncertainties. This approach also assures the global stability of the manipulator and its environment. While this paper concerns the fundamentals of compliant motion, part 2 of this paper [Reference 24] is devoted to the controller design method.
MGK VE MİLLİ GÜVENLİK KAVRAMI (1998)

Eskiden beri devletlerin temel endişesi kendilerini dışa karşı korumak olmuştur. Bu amaçla düzenli silahlı kuvvetler oluşturma yoluna gitmişlerdir, ancak iki dünya savaşı ve askeri teknolojinin hızla gelişerek savaşların boyutlarının değişmesi göstermiştir ki başlıbaşına silahlı kuvvetlerinin varlığı devletlerin güvenliğinin sağlanmasında yeterli değildir. Bu sebeple devletler özellikleII. Dünya Savaşı&#039;ndan sonra idari teşkilatlanma açısından yeniden yapılanmaya başlamışlardır. Teşkilatlanmanın en önemli sonuçlarından biri olarak da ülkemizde MGK benzeri kuruluşlar devlet teşkilatlarında yerini almıştır.Devlet teşkilatlanmalarındaki bu gelişmeye paralel bir biçimde milli güvenlik kavramı uluslararası metinlerde gerekse, iç hukuk metinlerinde daha çok yeralmaya başlamıştır.
Endosialin is expressed in high grade and advanced sarcomas: Evidence from clinical specimens and preclinical modeling (2011)

We previously surveyed the expression of endosialin/ CD248/TEM-1 by immunohistochemistry in human clinical specimens of sarcomas and documented expression in tumor cells, stromal cells and vasculature. In the present study, we completed a retrospective analysis of the diagnostic reports available for these same samples in order to identify high-grade and metastatic disease. Our results show that endosialin can be detected in advanced disease. We screened human sarcoma cell lines in vitro for endosialin expression and developed preclinical human xenograft models of disseminated sarcoma. We found that 22 out of 42 human sarcoma cell lines were positive for endosialin with a positive correlation between mRNA and protein levels. When implanted in vivo, endosialin was expressed at all sites of dissemination. These data provide clinical and preclinical evidence that endosialin can be detected in advanced sarcoma. These results demonstrate for the first time that endosialin is a suitable therapeutic target for poor prognosis and advanced disease.
Pool Boiling Experiments on a Nano-Structured Surface (2009)

The effect of nano-structured surfaces on pool boiling was investigated. Saturated and subcooled pool boiling experiments were performed on a horizontal heater surface coated with vertically aligned multiwalled carbon nanotubes (MWCNTs). MWCNTs were synthesized using the chemical vapor deposition (CVD) process. In this paper, MWCNT forests of two distinctly different heights (Type A: 9-mum height, and Type B: 25-mu m height) were synthesized separately on silicon wafers. PF-5060 was used as the test liquid. The results show that Type-B MWCNTs yield distinctly higher heat fluxes under subcooled and saturated conditions for both nucleate and film boiling. Type-A MWCNTs provide similar enhancement in nucleate boiling (as Type-B) for both saturated and subcooled conditions. Type-B MWCNTs enhanced critical heat flux (CHF) by 40%. Increasing the height of the MWCNTs is also found to extend the wall super heat required for CHF. In contrast, Type-A MWCNTs provide only marginal enhancement in film boiling compared to bare silicon wafer, for both saturated and subcooled film boiling. Type-B MWCNTs enhanced the heat flux in the film boiling regime for the Leidenfrost point by 175% (compared to bare silicon wafer).
Qualification Tests of HF RFID Foil Transponders for a Vehicle Guidance System (2007)

In the research project "TagDrive" RFID (radio frequency identification) passive transponders with 13.56 MHz operation frequency are used for an AGV (autonomous guided vehicle) and an automobile guidance system. A PMMA (polymethylmetacrylate) casing is developed for transponder protection and fixation on the floor of facility buildings and on roadway surface. To qualify both encasing and RFID system a speed and range test facility is developed to simulate the high vehicle velocity. The facility achieves a relative speed of 28 m/s (100 km/h) between reader unit and transponder. In addition a mechanical stress test facility is constructed to simulate vehicle weight and tire motion over encased transponders fixed on the ground. Finally, speed, range, mechanical, and climatic tests are carried out with existing and new test facilities.
Robust Seed Localization and Growing with Deep Convolutional Features for Scene Text Detection (2015)

Text detection in natural scene images is an open and challenging problem due to the significant variations of the appearance of the text itself and its interaction with the context. In this paper, we present a novel text detection method based on robust localization and adaptive growing of seed text components. The method consists of two main ingredients. First, convolutional neural network is exploited to localize seed candidate characters from the maximally stable extremal regions of the image with learned discriminative deep convolutional features. Next, an iterative and adaptive growing algorithm is employed to grow from seed characters to search for other degraded text components in same text line based on their conformity to the seed, and an associative quality is learned to measure the conformity combining both the geometric and appearance constraints between two neighbouring text components. The effectiveness of the proposed method is demonstrated by the state-of-the-art results achieved on the public datasets.
475. The interaction of aldehydes and ketones with monothioglycols (1959)

J. R. Marshall and H. A. Stevenson, J. Chem. Soc., 1959, 2360 DOI: 10.1039/JR9590002360
Differential Interactions of Nateglinide and Repaglinide on the Human β-Cell Sulphonylurea Receptor 1 (2002)

Repaglinide and nateglinide represent a new class of insulin secretagogues, structurally unrelated to sulphonylureas, that were developed for the treatment of type 2 diabetes. The inhibitory effect of these drugs was investigated on recombinant wild-type and mutant Kir6.2/SUR1 channels expressed in HEK293 cells. Nateglinide and repaglinide dose-dependently inhibited whole-cell Kir6.2/SUR1 currents with half-maximal inhibitory concentration (IC(50)) values of 800 and 21 nmol/l, respectively. Mutation of serine 1237 in SUR1 to tyrosine (S1237Y) abolished tolbutamide and nateglinide block, suggesting that these drugs share a common point of interaction on the SUR1 subunit of the ATP-sensitive K(+) channel. In contrast, repaglinide inhibition was unaffected by the S1237Y mutation (IC(50) = 23 nmol/l). Radioligand binding studies revealed a single high-affinity binding site for [(3)H]repaglinide on membranes prepared from HEK293 cells expressing wild-type (equilibrium dissociation constant [K(D)] = 0.40 nmol/l) or mutant (K(D) = 0.31 nmol/l) Kir6.2/SUR1 channels. Nateglinide and tolbutamide displaced [(3)H]repaglinide binding to wild-type channels with IC(50) values of 0.7 and 26 micro mol/l, respectively, but produced <10% displacement of [(3)H]repaglinide bound to mutant channels. This is consistent with the idea that binding of nateglinide and tolbutamide, but not repaglinide, is abolished by the SUR1[S1237Y] mutation and that the binding site for repaglinide is not identical to that of nateglinde/tolbutamide. These results are discussed in terms of a conformational analysis of the drug molecules.
Experience with integrating Java with new technologies (2002)

Java programmers cannot but be aware of Microsoft's new initiative - a complete language, network environment, and a host of supporting technologies under the title of C# .NET. We highlight the advantages of C# by presenting our experiences connecting it to Java in three ways. The first is by providing a platform and language-independent XML-based API called Views for developing programmer-controlled GUIs. Views does not need C#'s resource-intensive Visual Studio development environment, and is also targeted for Unix. The second provides evidence that C# can be linked to Java at the source code level, albeit through C++ wrappers. The third is a means for retaining the useful applet feature of Java in a server-side architecture of .NET's web services. We conclude that many common shared technologies bring Java and C# together and innovative ways of using others will open up opportunities not hitherto imagined.
ChemInform Abstract: A Direct Preparation of Silyl Oxazoles: A Dramatic Chemoselectivity Difference Between R<sub>3</sub>SiOTf and R<sub>3</sub>SiCl. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Parameter Optimization in Pulsed DC Reactive Sputter Deposition of Aluminum Oxide (2002)

Pulsed dc power supplies provide enabling capability to dielectric reactive sputtering applications due to their ability to reduce or even eliminate arcing during the deposition process. As this technology matures there has been increasing interest in the semiconductor, optical and industrial coating industries to use pulsed-dc sputter supplies for difficult to deposit films. The fundamental behavior of reverse-voltage pulsing and its ability to reduce arcing has been studied [1,2] but little work has been published on optimizing the available parameters to provide maximum rate, minimum arc activity and maximized process stability and system utilization. Previous studies have shown that in the range of 20 to 100 kHz there is a strong relationship between arc activity and reverse pulse time. In one study a critical duty factor was identified at a pulsing frequency of 60 kHz where arc free operation was obtained over an extended operating period [1]. This paper intends to expand upon these findings to explore whether an optimum duty factor may be established throughout the available frequency spectrum of today’s generation pulsed-dc power supplies. Furthermore, little is understood of how arc intensity, i.e. energy released during the arc, can affect process stability and longevity. Recent technological advances in pulsed-dc power supplies have allowed the range of pulsing frequencies to extend beyond 300 kHz and system architecture now allows for arc intensity discrimination. This study capitalizes on these capabilities as well as the more traditional controls of reverse time (duty factor) and reverse voltage in an effort to characterize their relationship to arc density, and long term process reliability during the reactive deposition of dielectric Al 2 O 3 .
Optical clock recovery from a data stream of an arbitrary bit rate by use of stimulated Brillouin scattering (1995)

Using a fiber-optic stimulated-Brillouin-scattering amplifier as an active filter, we have demonstrated optical clock recovery from 5-Gbit/s return-to-zero-format optical data. Definite patterns and pseudorandom bit sequences were tested. This scheme requires no prior knowledge of the clock frequency and is well suited for operation at higher data rates.
TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis (2013)

Psoriasis is an inflammatory disease of the skin affecting 2-3% of the population, characterized by a thickening of the epidermis and immune infiltrates throughout the dermis and epidermis, causing skin lesions that can seriously affect quality of life. The study of psoriasis has historically been hampered by the lack of good animal models. Various genetically induced models exist, which have provided some information about possible mechanisms of disease, but these models rely mostly on intrinsic imbalances of homeostasis. However, a mouse model of psoriasiform dermatitis caused by the repeated topical application of Aldara™ containing 5% imiquimod was described in 2009. The mechanisms of action of Aldara™ are complex. Imiquimod is an effective ligand for TLR7 (and TLR8 in humans) and also interferes with adenosine receptor signaling. In addition, isostearic acid present in the Aldara™ vehicle has been shown to be biologically active and of importance for activating the inflammasome. Interestingly, the repetitive application of Aldara™ reveals a complex aetiology involving multiple cell types, cytokines, and inflammatory pathways. In this review, we will dissect the findings of the imiquimod model to date and ask how this model can inform us about the immunological aspects of human disease.
DNA hybridization procedure to detect pseudorabies virus DNA in swine tissue. (1985)

A DNA hybridization technique was developed to detect the presence of pseudorabies virus (PRV) DNA. P Nick translated probes of high specific activity were prepared from transformed Escherichia coli plasmids into which Bacillus amyloliquefaciens H (Bam H1) restriction fragments of PRV DNA had been inserted. Swine cellular DNA and tissue culture PRV DNA were digested with Bam H1, separated by agarosegel electrophoresis, transferred onto nitrocellulose paper, hybridized to the radioactive probes, and washed under high stringency conditions; autoradiographs were then prepared. Under the optimal hybridization conditions described, the detection limit of these probes was 10(-11)g of PRV DNA. In reconstruction experiments, 3 of the selected probes cross hybridized with digested swine cellular DNA, and 4 probes did not. The addition of polyuridylic acid and polyguanylic acid to the hybridization reactions did not alter the amount of hybridization. The results indicated that this procedure may be useful for studying the latency of pseudorabies viral infection.
An integrated geographical information system's approach to land cover change assessment (2005)

A new methodology has been developed for the land cover change assessment using the integrated GIS approach. Inherent shortcomings of raster change detection techniques have been identified for use with vector formatted land cover data. There was a need for an established procedure for the assessment of land cover change using a vector based GIS. In this paper, a methodology using mathematical concepts of sets and groups has been developed. Such a methodology was successfully implemented for the analysis of historical land cover change from 1931 to 1989 in the River Glen catchment, UK. Algorithms have been developed for automatic derivation of dynamic statistics of land cover. It has been demonstrated that this approach can be efficiently adopted for an operational use incorporating the products derived from both the coarse and fine resolution remotely-sensed satellite images.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Influencing the Angular Emission of a Single Molecule (2000)

We present the first experimental proof for the influence of a nearby nanosized metal object on the angular photon emission by a single molecule. Using a novel angular sensitive detection scheme, we directly quantify the redirection of angular emission for different molecular dipole orientations as an object is scanned laterally over the molecule at different heights. An excellent agreement between experiments and 2D-numerical simulations is found for molecules oriented perpendicular to the sample, whereas, for parallel orientations, the observed behavior contradicts the calculated behavior.
Activation of enhancer elements by the homeobox gene Cdx2 is cell line specific (1997)

Cdx2 is a caudal-related homeodomain transcription factor that is expressed in complex patterns during mouse development and at high levels in the intestinal epithelium of adult mice. Cdx2 activates transcription of intestinal gene promoters containing specific binding sites. Moreover, Cdx2 has been shown to induce intestinal differentiation in cell lines. In this study, we show that Cdx2 is able to bind to two well defined enhancer elements in the HoxC8 gene. We then demonstrate that Cdx2 is able to activate transcription of heterologous promoters when its DNA binding element is placed in an enhancer context. Furthermore, the ability to activate enhancer elements is cell-line dependent. When the Cdx2 activation domain was linked to the Gal4 DNA binding domain, the chimeric protein was able to activate Gal4 enhancer constructs in an intestinal cell line, but was unable to activate transcription in NIH3T3 cells. These data suggest that there are cell-specific factors that allow the Cdx2 activation domain to function in the activation of enhancer elements. We hypothesize that either a co-activator protein or differential phosphorylation of the activation domain may be the mechanism for intestinal cell line-specific function of Cdx2 and possibly in other tissues in early development.
Über die Wertigkeit des Kobalts in Azofarbstoffkomplexen (1968)

Abstract The Co II ‐azocomplexes (1:2) have been prepared and the conditions for their existence are defined. The oxidation to the Co III ‐complex by either oxygen or by the dyestuff itself is described. In the case of dyestuff‐oxidation, the azo group is reduced to the respective amines. The formation of Co III ‐azocomplexes in a technical scale by metallizing with Co II ‐salts is discussed.
Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model (2002)

Mutations of survival of the motor neuron gene (SMN1) are responsible for spinal muscular atrophy (SMA), a common genetic cause of death in childhood. The cellular mechanism by which mutations of SMN1 are responsible for the selective neuromuscular defect and motor neuron cell degeneration observed in SMA has not been described. We have previously generated mice carrying a homozygous deletion of Smn exon 7 directed to neurons. We report here that these mutant mice display a dramatic and progressive loss of motor axons involving both proximal and terminal regions, in agreement with the skeletal muscle denervation process and disease progression. Moreover, we found massive accumulation of neurofilaments, including phosphorylated forms, in terminal axons of the remaining neuromuscular junctions. This aberrant cytoskeletal organization of synaptic terminals was associated with reduction of branched structures of the postsynaptic apparatus and defect of axonal sprouting in mutant mice. Together, these findings may be responsible for severe motor neuron dysfunction, and suggest that loss of motor neuron cell bodies results from a 'dying-back' axonopathy in SMA. Smn mutant mice should represent a valuable model for elucidating the pathway linking Smn to cytoskeletal organization.
Poly (rC) binding protein 2 forms a ternary complex with the 5'-terminal sequences of poliovirus RNA and the viral 3CD proteinase. (1997)

Poly(rC) binding protein 2 (PCBP2) forms a specific ribonucleoprotein (RNP) complex with the 5'-terminal sequences of poliovirus genomic RNA, as determined by electrophoretic mobility shift assay. Mutational analysis showed that binding requires the wild-type nucleotide sequence at positions 20-25. This sequence is predicted to localize to a specific stem-loop within a cloverleaf-like secondary structure element at the 5'-terminus of the viral RNA. Addition of purified poliovirus 3CD to the PCBP2/RNA binding reaction results in the formation of a ternary complex, whose electrophoretic mobility is further retarded. These properties are consistent with those described for the unidentified cellular protein in the RNP complex described by Andino et al. (Andino R, Rieckhof GE, Achacoso PL, Baltimore D, 1993, EMBO J 12:3587-3598). Dicistronic RNAs containing mutations in the 5' cloverleaf-like structure of poliovirus that abate PCBP2 binding show a decrease in RNA replication and translation of gene products directed by the poliovirus 5' noncoding region in vitro, suggesting that the interaction of PCBP2 with these sequences performs a dual role in the virus life cycle by facilitating both viral protein synthesis and initiation of viral RNA synthesis.
The phase vocoder: theory and practice (1997)

This article discusses the theoretical principles governing the short time Fourier transform (STFT) and its musical applications, using the CARL phase vocoder and the Composers' Desktop Project (CDP) spectral transformations. The former was originally developed by Dolson (1986, 1991) and ported to personal computer systems by Atkins, Bentley, Henderson, Orton and Wishart (Atkins, Bentley, Endrich, Fischman, Malham, Orton and Wishart 1987, Wishart 1994a). The latter was developed by Wishart (1994b). When possible, theoretical matters are presented in a qualitative way, keeping the number and complexity of mathematical expressions within the essential requirements for those interested in musical applications. The latter are accompanied by sound examples, including excerpts from pieces by the author.
Ramifications of traumatic brain injury for sexuality (1990)

This article examines the perceptions of rehabilitation-staff members and brain-injured patients on the effects of brain injury on sexuality. It explores some of the problems faced by both staff members and patients in a large acute-brain-injury rehabilitation facility. In general, the main problem of patients, identified by both patients and staff, was opportunity for intimate social and sexual interaction.
24.8 A 14nm fractional-N digital PLL with 0.14ps<inf>rms</inf> jitter and −78dBc fractional spur for cellular RFICs (2017)

To meet ever-growing demands for higher mobile data-rates, LTE standards continue to evolve. While carrier aggregation (CA) improves data-rates, it requires wider aggregated signal bandwidth that limits the number of users that can be serviced. Techniques like 256QAM and 4×4 MIMO are attractive because improvements do not need wider signal bandwidth. To support 256QAM and 4×4 MIMO for the 5GHz band, we need IPN better than −48dBc or 155fsec rms. A digital fractional-N PLL that achieves 137fsec rms jitter integrating from 10kHz to 10MHz (or 142fsec 1kHz to 10 MHz) with a −78.6dBc near integer-N fractional spur is presented. We have introduced a TDC chopping technique, fine-conversion through SARADCs and TDC nonlinearity calibration to improve IPN and fractional spurs.