gebhart/patrepeval huggingface dataset:
Multiple brain atlas database and atlas-based neuroimaging system (1997)

For the purpose of developing multiple, complementary, fully labeled electronic brain atlases and an atlas-based neuroimaging system for analysis, quantification, and real-time manipulation of cerebral structures in two and three dimensions, we have digitized, enhanced, segmented, and labeled the following print brain atlases: Co-Planar Stereotaxic Atlas of the Human Brain by Talairach and Tournoux, Atlas for Stereotaxy of the Human Brain by Schaltenbrand and Wahren, Referentially Oriented Cerebral MRI Anatomy by Talairach and Tournoux, and Atlas of the Cerebral Sulci by Ono, Kubik, and Abernathey. Three-dimensional extensions of these atlases have been developed as well. All two- and three-dimensional atlases are mutually preregistered and may be interactively registered with an actual patient's data. An atlas-based neuroimaging system has been developed that provides support for reformatting, registration, visualization, navigation, image processing, and quantification of clinical data. The anatomical index contains about 1,000 structures and over 400 sulcal patterns. Several new applications of the brain atlas database also have been developed, supported by various technologies such as virtual reality, the Internet, and electronic publishing. Fusion of information from multiple atlases assists the user in comprehensively understanding brain structures and identifying and quantifying anatomical regions in clinical data. The multiple brain atlas database and atlas-based neuroimaging system have substantial potential impact in stereotactic neurosurgery and radiotherapy by assisting in visualization and real-time manipulation in three dimensions of anatomical structures, in quantitative neuroradiology by allowing interactive analysis of clinical data, in three-dimensional neuroeducation, and in brain function studies.
Clinical and radiological correlates of activities of daily living in cerebellar atrophy caused by PMM2 mutations (PMM2-CDG) (2021)

We aimed to identify clinical, molecular and radiological correlates of activities of daily living (ADL) in patients with cerebellar atrophy caused by PMM2 mutations (PMM2-CDG), the most frequent congenital disorder of glycosylation. Twenty-six PMM2-CDG patients (12 males; mean age 13 ± 11.1 years) underwent a standardized assessment to measure ADL, ataxia (brief ataxia rating scale, BARS) and phenotype severity (Nijmegen CDG rating scale, NCRS). MRI biometry of the cerebellum and the brainstem were performed in 23 patients (11 males; aged 5 months-18 years) and 19 control subjects with equal gender and age distributions. The average total ADL score was 15.3 ± 8.5 (range 3-32 out of 36 indicating severe functional disability), representing variable functional outcome in PMM2-CDG patients. Total ADL scores were significantly correlated with NCRS (r<sup>2</sup> = 0.55, p < 0.001) and BARS scores (r<sup>2</sup> = 0.764; p < 0.001). Severe intellectual disability, peripheral neuropathy, and severe PMM2 variants were all significantly associated with worse functional outcome. Higher ADL scores were significantly associated with decreased diameters of cerebellar vermis (r<sup>2</sup> = 0.347; p = 0.004), hemispheres (r<sup>2</sup> = 0.436; p = 0.005), and brainstem, particularly the mid-pons (r<sup>2</sup> = 0.64; p < 0.001) representing the major radiological predictor of functional disability score in multivariate regression analysis. We show that cerebellar syndrome severity, cognitive level, peripheral neuropathy, and genotype correlate with ADL used to quantify disease-related deficits in PMM2-CDG. Brainstem involvement should be regarded among functional outcome predictors in patients with cerebellar atrophy caused by PMM2-CDG.
[New data on the biological action of normal immunoglobulins]. (1986)

Experiments on 2,520 CBA mice (CBA X X C57BL) F1 nice have shown that the injection of homologous serum immunoglobulins (obtained from intact and blood-stimulated animals), made 2 hours after gamma irradiation from a 60Co source, prevents the development of intestinal dysbacteriosis and endogenous infection. The injection of mouse and human immunoglobulins to nonirradiated mice improved their resistance to experimental infection with Escherichia coli live culture, increased the expression of receptors to the Fc-fragments of IgG in peritoneal macrophages and enhanced the physical working capacity of the animals. The preparations containing normal antitissular antibodies have proved to be particularly effective. In mice, rabbits and dogs the preparations under test have produced no changes in the general state of the animals, no local reactions and no disturbances in the cardiovascular activity.
Nuclear magnetic resonance (NMR) in clinical pathology: current trends. (1984)

Journal Article Nuclear magnetic resonance (NMR) in clinical pathology: current trends. Get access C E Brown, C E Brown Search for other works by this author on: Oxford Academic Google Scholar J H Battocletti, J H Battocletti Search for other works by this author on: Oxford Academic Google Scholar L F Johnson L F Johnson Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 30, Issue 5, 1 May 1984, Pages 606–618, https://doi.org/10.1093/clinchem/30.5.606 Published: 01 May 1984
Building an effective global business team (2002)

This publication contains reprint articles for which IEEE does not hold copyright. Full text is not available on IEEE Xplore for these articles.
An experimental and clinical study of immunocompetence and immunostimulation in breast cancer. (1988)

Two hundred and seven patients aged from 37 to 65 years with noninflammatory breast cancer treated by surgery without radiation were studied over a ten year period with a view to forecasting the prognosis on the basis of the immune status and treatment. The immunocompetence or immune status was studied in 121 patients by in vitro and in vivo pre and post-surgical skin tests. The immunostimulation or restoration of the immune status was conducted by the P 40 immunomodulator from the Pasteur Institute: in an experimental study whose results are based on modified Huggins model and take in to account the survival rate and the evaluation of tumor growth; in a subgroup of 86 patients, demonstrating that immunostimulation is effective in low-scores, improves tolerance to chemotherapy and increases the six year survival rate in high risk low-score patients. The results are encouraging enough to propose improving the survival rate in a prospective clinical study of early breast cancer treated by local and regional means using a protocol incorporating an immunostimulation based on the existing immunocompetence with interferon-induced reconversion of the target cells in the hope of specific stimulation.
Vemurafenib<b>for the treatment of melanoma</b> (2012)

Vemurafenib is an oral agent licensed for patients with BRAF V600E mutation-positive inoperable and metastatic melanoma. The most common adverse effects observed in Phase III clinical trials were dermatological events, arthralgia and fatigue. Specific dermatological toxicities included development of cutaneous squamous cell cancers and keratoacanthomas. Prolongation of the QT interval was also reported. Regular dermatological assessments and electrocardiograms are recommended. Ongoing trials are examining vemurafenib in both the adjuvant setting and metastatic setting in combination with ipilimumab and MEK inhibitors (mitogen-activated protein kinase/extracellular signal-regulated kinase). Understanding and overcoming mechanisms of resistance to BRAF inhibitors is the focus of ongoing research.
Electron Emission Spectra of Alkaline Earth Fluorides (1970)

Abstract The photostimulated electron emission spectra of CaF 2 , SrF 2 , and BaF 2 crystals, coloured by electron bombardment, are analysed. The comparison with optical absorption spectra leads to some conclusions with respect to the kind of colour centres corresponding to the various bands observed. The results verify a relation of the Mollwo‐Ivey type. Some complex bands are resolved.
Image-based mobile service: automatic text extraction and translation (2010)

We present a new mobile service for the translation of text from images taken by consumer-grade cell-phone cameras. Such capability represents a new paradigm for users where a simple image provides the basis for a service. The ubiquity and ease of use of cell-phone cameras enables acquisition and transmission of images anywhere and at any time a user wishes, delivering rapid and accurate translation over the phone's MMS and SMS facilities. Target text is extracted completely automatically, requiring no bounding box delineation or related user intervention. The service uses localization, binarization, text deskewing, and optical character recognition (OCR) in its analysis. Once the text is translated, an SMS message is sent to the user with the result. Further novelties include that no software installation is required on the handset, any service provider or camera phone can be used, and the entire service is implemented on the server side.
Neue Benzothiazine, III. 3.4‐Dihydro‐1 <i>H</i>‐2.1‐, 3.4‐Dihydro‐2<i>H</i>‐1.2‐ und 3.4‐Dihydro‐1<i>H</i>‐2.3‐benzothiazin‐S.S‐dioxid (1971)

Abstract 3.4‐Dihydro‐1 H ‐2.1‐benzothiazin‐2.2‐dioxid ( 2 ) wird durch Dehydratisierung der Amino‐sulfonsäure 1 oder durch Pyrolyse des Hydrochlorids des entsprechenden Amino‐sulfonamids 3 dargestellt. 3.4‐Dihydro‐2 H ‐1.2‐benzothiazin‐1.1‐dioxide 13 werden analog durch Dehydratisierung von 11 und außerdem durch Hydrierung der sauren Lösung des Cyan‐sulfonamids 12 oder durch Alkali‐Behandlung der Chloräthyl‐sulfonamide 17 dargestellt. Ähnlich werden aus der Amino‐sulfonsäure 27 , den Chlor‐sulfonamiden 31 und dem Amino‐sulfonamid 33 die 3.4‐Dihydro‐1 H ‐2.3‐benzothiazin‐2.2‐dioxide 28 erhalten. Einige Alkylierungs‐ und Nitrierungsprodukte werden beschrieben.
Ideal and feared selves in the selective self-reference task (2003)

It is argued that high mnemonic performance demonstrated in the ideal-self reference task did not unequivocally show that richness and organization of knowledge in the ideal self were responsible for performance. Accordingly, this study used goal-evaluation task, in which the participants classified each trait into either "want to be" or "not want to be" category. In this way, richness and organization of knowledge in the ideal and "feared selves" were compared. In Experiment 1, recall performance under goal evaluation condition was compared with that under actual and ideal self-reference conditions, and no significant difference was found. In Experiment 2, the task-facilitation paradigm was used to test weather the goal evaluation task was performed be selectively accessing the two sets of self-knowledge. As a whole, results suggested that the task required selective access to both selves, and reflected richness and organization of knowledge for both ideal and feared selves.
Resistance Screening Essay of Wine Lactic Acid Bacteria on Lysozyme:  Efficacy of Lysozyme in Unclarified Grape Musts (2004)

In wine making, the bacteriolytic activity of lysozyme has primarily been used to control the malolactic fermentation in wines. The use of lysozyme in musts before settling and the beginning of the alcoholic fermentation to inhibit the growth of lactic acid bacteria could be very beneficial. In a resistance test carried out in MT/b broth, lysozyme had greater antimicrobial activity toward Oenococcus oeni than Lactobacillus species. Several strains of wine bacteria belonging to Oenococcus proved sensitive to the bacteriolytic activity of lysozyme at low concentrations in both synthetic medium (MT/b) (50 mg/L), white must, or red must made with or without the skins (100 mg/L). Lactobacillus and Pediococcus strains survived at lysozyme concentrations of 200-500 and 500 mg/L, respectively, in MT/b and musts. Suspended solids in unclarified musts may strongly bind to lysozyme thereby causing its removal by filtration or centrifugation. One hour after lysozyme was added to musts, it was quantified by HPLC and found after centrifugation to be 40-50% and only 10% in musts made with or without the skins, respectively. Although appreciable amounts of lysozyme were bound to wine components, this did not appear to be a serious hindrance to lysozyme activity.
Improved Identification of Epidemiologically Related Strains of <i>Salmonella enterica</i> by use of a Fusion Algorithm Based on Pulsed-Field Gel Electrophoresis and Multiple-Locus Variable-Number Tandem-Repeat Analysis (2010)

Pulsed-field gel electrophoresis (PFGE) and multiple-locus variable-number tandem-repeat analysis (MLVA) are used to assess genetic similarity between bacterial strains. There are cases, however, when neither of these methods quantifies genetic variation at a level of resolution that is well suited for studying the molecular epidemiology of bacterial pathogens. To improve estimates based on these methods, we propose a fusion algorithm that combines the information obtained from both PFGE and MLVA assays to assess epidemiological relationships. This involves generating distance matrices for PFGE data (Dice coefficients) and MLVA data (single-step stepwise-mutation model) and modifying the relative distances using the two different data types. We applied the algorithm to a set of Salmonella enterica serovar Typhimurium isolates collected from a wide range of sampling dates, locations, and host species. All three classification methods (PFGE only, MLVA only, and fusion) produced a similar pattern of clustering relative to groupings of common phage types, with the fusion results being slightly better. We then examined a group of serovar Newport isolates collected over a limited geographic and temporal scale and showed that the fusion of PFGE and MLVA data produced the best discrimination of isolates relative to a collection site (farm). Our analysis shows that the fusion of PFGE and MLVA data provides an improved ability to discriminate epidemiologically related isolates but provides only minor improvement in the discrimination of less related isolates.
Efficient Attack on Non-linear Current Mirror PUF with Genetic Algorithm (2016)

Physical Unclonable Function (PUF) is a new hardware security primitive that exploits the manufacturing variations of integrated circuits. Traditional arbiter PUF is vulnerable to machine learning based modeling attacks due to its linearity. Current mirror PUF uses non-linear current mirror to bring non-linearity into the challenge-response relationship and is claimed resistant to modeling attacks. This paper further tests its security, and proves that the current mirror PUF is not as secure as claimed. A genetic algorithm based method is proposed to attack the current mirror PUF. By modeling the relationship between the output current and the input current of each current mirror, and fitting the model using genetic algorithm, we are able to predict the responses of current mirror PUF. Experiments prove that the prediction accuracy towards current mirror PUF is up to 99.27%.
Ventriculostomy-related infections in critically ill patients: a 6-year experience (2005)

In this large series of patients, VRI was associated with a longer ICU stay, but its presence did not influence survival. A longer duration of ventriculostomy catheter monitoring in patients with VRI might be due to an increased volume of drained CSF during infection. Risk factors associated with VRIs are SAH, IVH, craniotomy, and coinfection.
Reverse engineering gene regulatory networks (2005)

Abstract Complex networks of genes, proteins, and small molecules interact to determine cellular function. The reverse engineering or inference of gene regulatory networks using DNA sequence data, protein–DNA binding data, and observed molecular abundance data has become a major interest of the biological community. We discuss recent successes and remaining challenges in the construction of gene network models and their use for gaining biological insight. We draw lessons from the detailed discussion of several recent gene network inference studies, focusing on the novel advances and limitations of each approach. These approaches differ in the strategies used to incorporate biological data, the level of physical detail and type of model used, and the purpose of the modeling in terms of biological discovery. The approaches we discuss aim to gain insights into the logic of combinatorial regulation occurring at a gene promoter, the activity of regulatory factors distinct from their abundance, the identification of key regulators in a gene network, and the prediction of drug compound mode of action. We suggest possibilities for future directions in network inference studies.
Obsessive‐compulsive disorder (1992)

Abstract Obsessive‐compulsive disorder, a neurobiological disease associated with abnormalities in the basal ganglia, responds with some success to behavior modification and also to new pharmacological therapies.
Temperature-dependent supramolecular stereoisomerism in porous copper coordination networks based on a designed carboxylate ligand (2005)

Two novel temperature-controlled supramolecular stereoisomers of porous copper coordination networks have been synthesized and characterized.
Discriminability of the Quality of Amplitude-Compressed Speech (1984)

In an earlier experiment on intelligibility of amplitude-compressed speech, subjects could not hear a difference between noncompressed speech and speech under some conditions of compression. Therefore, compression conditions were determined in which the quality of the two types of speech could be distinguished. When speech average level was 10 dB above a masking noise, compression ratio (CR) was equal to 2.5, and the attack time (Ta) was 3 ms, the release time (Tr) had to be shorter than 120 ms to achieve discrimination by trained normal-hearing subjects. With longer attack times and/or higher compression ratios, the critical value of release times increased. Thus, the range in which the discrimination was observed also increased (for CR = 5 and Ta = 10 ms, the critical Tr was 360 ms). The discrimination of our hearing-impaired subjects was much worse than that of the normal-hearing subjects. For example, speech processed with CR = 10, Ta = 1 ms, and Tr = 10 ms could be distinguished from the noncompressed by only 50% of the impaired subjects.
The multiple roles of antibiotics and antibiotic resistance in nature (2013)

EDITORIAL article Front. Microbiol., 27 August 2013Sec. Antimicrobials, Resistance and Chemotherapy Volume 4 - 2013 | https://doi.org/10.3389/fmicb.2013.00255
Absorption, carrier lifetime, and gain in inas~gaas quantum-dot infrared photodetectors (2003)

Quantum-dot infrared photodetectors (QDIPs) are being studied extensively for mid-wavelength and long-wavelength infrared detection because they offer normal-incidence, high-temperature, multispectral operation. Intersubband absorption, carrier lifetime, and gain are parameters that need to be better characterized, understood, and controlled in order to realize high-performance QDIPs. An eight-band k/spl middot/p model is used to calculate polarization-dependent intersubband absorption. The calculated trend in absorption has been compared with measured data. In addition, a Monte-Carlo simulation is used to calculate the effective carrier lifetime in detectors, allowing the calculation of gain in QDIPs as a function of bias. The calculated gain values can be fitted well with experimental data, revealing that the gain in these devices consists of two mechanisms: photoconductive gain and avalanche gain, where the latter is less dominant at normal operating biases.
Inclusion Behavior of Thiacalix[4]arenetetrasulfonate toward Water-Miscible Organic Molecules Studied by Salting-Out and X-ray Crystallography (2002)

[reaction: see text] Inclusion ability of thiacalix[4]arenetetrasulfonate (TCAS) toward water-miscible organic molecules such as alcohols, ketones, cyclic ethers, and so on was studied by salting-out of the inclusion complex. NMR spectra of the recovered precipitates showed size selectivity to include the guest molecules. X-ray crystallographic analyses of TCAS salts including acetone and 1,4-dioxane suggested that guests are retained with the aid of cation coordination and H-bonding.
Nicotinamide extends replicative lifespan of human cells (2006)

We found that an ongoing application of nicotinamide to normal human fibroblasts not only attenuated expression of the aging phenotype but also increased their replicative lifespan, causing a greater than 1.6-fold increase in the number of population doublings. Although nicotinamide by itself does not act as an antioxidant, the cells cultured in the presence of nicotinamide exhibited reduced levels of reactive oxygen species (ROS) and oxidative damage products associated with cellular senescence, and a decelerated telomere shortening rate without a detectable increase in telomerase activity. Furthermore, in the treated cells growing beyond the original Hayflick limit, the levels of p53, p21WAF1, and phospho-Rb proteins were similar to those in actively proliferating cells. The nicotinamide treatment caused a decrease in ATP levels, which was stably maintained until the delayed senescence point. Nicotinamide-treated cells also maintained high mitochondrial membrane potential but a lower respiration rate and superoxide anion level. Taken together, in contrast to its demonstrated pro-aging effect in yeast, nicotinamide extends the lifespan of human fibroblasts, possibly through reduction in mitochondrial activity and ROS production.
Maximum MIMO Flow in wireless networks under the SINR model (2014)

We present a framework for the maximum flow problem in wireless networks using the SINR interference model in combination with MIMO nodes. The performance ratio of our algorithm matches the best O(log n) approximation factor known for the pure flow problem, but avoids the impractical dependence on the ellipsoid method and features both simpler and more intuitive analysis. The objective of a maximum flow in wireless networks is to get as much information from a sender to a receiver using intermediate nodes in a multi-hop environment. The algorithm is based on an LP formulation of the flow problem, and handles gracefully all additional linear constraints. The set of constraints that can be included contains, among other, power limits, fairness between source-sink pairs, capacity limits and bounds, and the use of Multi-Input Multi-Output nodes for the source and the sink nodes, which are often the bottlenecks in a wireless flow.
Karl Völker (Prof. an der Evangelisch - Theologischen Fakultät der Universität Wien), Kirchengeschichte Polens (1931)

Article Karl Völker (Prof. an der Evangelisch - Theologischen Fakultät der Universität Wien), Kirchengeschichte Polens was published on August 1, 1931 in the journal Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Kanonistische Abteilung (volume 20, issue 1).
Performance of multicode DS-CDMA using frequency domain equalisation in frequency selective fading channel (2003)

For the reception of multicode direct sequence (DS)-CDMA signals, the MMSE frequency domain equalisation is applied instead of RAKE combining. The achievable BER performance in a frequency selective Rayleigh fading channel is evaluated by computer simulation. It is shown by computer simulation that the DS-CDMA with MMSE frequency domain equalisation outperforms the DS-CDMA with RAKE combining and shows only slight performance degradation compared to the MC-CDMA with minimum mean square error combining (MMSEC).