gebhart/patrepeval huggingface dataset:
Crystallographic studies on retinoidal-active and -inactive aromatic anilides (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystallographic studies on retinoidal-active and -inactive aromatic anilidesYoshiharu Toriumi, Atsushi Kasuya, and Akiko ItaiCite this: J. Org. Chem. 1990, 55, 1, 259–263Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/jo00288a043https://doi.org/10.1021/jo00288a043research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Model predictive economic/environmental dispatch of power systems with intermittent resources (2009)

This paper presents potential benefits of applying model predictive control (MPC) to solving the multi-objective economic/environmental dispatch problem in electric power systems with many intermittent resources. Based on the predictive model of the available output in the next short time period (e.g. 5 minutes) from the intermittent resources, this paper introduces a look-ahead optimal control algorithm for dispatching the available generation resources with the objective of minimizing objective function comprising both generation and environmental costs. This method is compared with (1) the static economic dispatch which treats intermittent resources as uncertain negative loads, and (2) the MPC dispatch with single objective function of minimizing the total generation cost. We show that the proposed MPC approach could lower the generation costs by directly dispatching the generator output from the renewable resources in order to compensate temporal load variations over pre-defined time horizon. Furthermore, the multi-objective economic/environmental cost function provides a formulation to study the tradeoff of efficiency and environmental impact in future energy systems. Simulation is implemented in a 12-bus power system comprising five generators to illustrate potential benefits from this look-ahead dispatch of both intermittent and more conventional power plants. The proposed method is directly applicable to managing power systems with large presence of wind and photovoltaic resources.
Antitumor Activities of a Novel Fluoropyrimidine, N4-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine (Capecitabine). (1998)

Capecitabine (N4-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine) is a novel fluoropyrimidine carbamate that was synthesized for the purpose of finding antitumor drugs with improved safety and efficacy profiles compared with those of 5-fluorouracil (5-FUra) and doxifluridine (5'-deoxy-5-fluorouridine, 5'-dFUrd). The present study compared the antitumor activities of the compound with those of other fluoropyrimidines in 12 human cancer xenograft models and their antimetastatic activities in murine tumor models. The antitumor efficacy of capecitabine was greater than those of 5'-dFUrd, UFT (a mixture of tegafur and uracil) and 5-FUra. Capecitabine was also much safer, particularly much less toxic to the intestinal tract, than the other compounds, indicating higher therapeutic indices. The therapeutic indices of capecitabine, 5'-dFUrd and 5-FUra were >40, >20 and 2.0 against the human CXF280 colon cancer xenograft, the most sensitive line to the fluoropyrimidines so far tested, and 5.1, 1.5, and <1.5 against the human HCT116 colon cancer xenograft with ordinary sensitivity, respectively. In addition, capecitabine, as well as 5'-dFUrd, selectively suppressed the spontaneous metastasis of mouse Lewis lung carcinoma in mice at extremely low doses, 32-64 fold lower than their minimum effective dose (MED) against the primary tumor growth. Capecitabine was even more antimetastatic than 5'-dFUrd. These results indicate that capecitabine has high therapeutic potential.
Adaptive calibration of multiple quantization oversampled A/D converters (2002)

Multiple quantization delta-sigma modulators for oversampled A/D conversion are known to suffer from performance degradation in the presence of analog imperfections in the implementation, such as finite gain of the amplifiers and capacitor ratio mismatches. We present algorithms and architectures for on-line and off-line digital correction of such analog imperfections. The digital correction compensates for incomplete cancellation of quantization noise from individual delta-sigma stages, and for gain and spectral distortion of the signal transfer function. Simulation results demonstrate that a simple off-line calibration method is effective to achieve neat-perfect digital correction of analog sources of error and spectral distortion. We discuss on-line extensions of the calibration procedure in a multiplexed or multi-rate arrangement with multiple oversampled converters operating in parallel.
Characterization of Aspergillus nidulans Mutants in Carbon Metabolism Isolated after D-Galacturonate Enrichment (1986)

A selective method for the isolation of Aspergillus nidulans mutants defective in the pyruvate dehydrogenase complex was devised. The essential steps in the procedure were a mutagenic treatment of conidia with X-rays to about 50% survival, followed by filtration enrichment in minimal medium with D-galacturonate as sole carbon source, and rescue on complete medium with acetate. The mutants thus isolated were phenotypically characterized on the basis of growth tests, and different genotypes were assigned on the basis of complementation tests. The majority of the mutants that were unable to utilize galacturonate were defective in one of the components of the pyruvate dehydrogenase complex. In addition, mutants defective in pyruvate carboxylase, mutants defective in glycerol catabolism and some novel mutants which were only unable to use D-galacturonate as carbon source were found. At least two genes were shown to be involved in D-galacturonate metabolism.
Supporting Developers' Coordination in the IDE (2015)

Teamwork in software engineering is time-consuming and problematic. In this paper, we explore how to better support developers' collaboration in teamwork, focusing on the software implementation phase happening in the integrated development environment (IDE). Conducting a qualitative investigation, we learn that developers' teamwork needs mostly regard coordination, rather than concurrent work on the same (sub)task, and that developers successfully deal with scenarios considered problematic in literature, but they have problems dealing with breaking changes made by peers on the same project. We derive implications and recommendations. Based on one of the latter, we analyze the current IDE support for receiving code changes, finding that historical information is neither visible nor easily accessible. Consequently, we devise and qualitatively evaluate Bellevue, the design of an IDE extension to make received changes always visible and code history accessible in the editor.
Bulk synthesis, growth mechanism and properties of highly pure ultrafine boron nitride nanotubes with diameters of sub-10 nm (2011)

As a structural analogue of the carbon nanotube (CNT), the boron nitride nanotube (BNNT) has become one of the most intriguing non-carbon nanostructures. However, up to now the pre-existing restrictions/limitations of BNNT syntheses have made the progress in their research rather modest. This work presents a new route toward the synthesis of highly pure ultrafine BNNTs based on a modified boron oxide (BO) CVD method. A new effective precursor--a mixture of Li₂O and B--has been proposed for the growth of thin, few-layer BNNTs in bulk amounts. The Li₂O utilized as the precursor plays the crucial role for the present nanotube growth. The prepared BNNTs have average external diameters of sub-10 nm and lengths of up to tens of µm. Electron energy loss spectrometry and Raman spectroscopy demonstrate the ultimate phase purity of the ultrafine BNNTs. Property studies indicate that the ultrafine nanotubes are perfect electrical insulators exhibiting superb resistance to oxidation and strong UV emission. Moreover, their reduced diameters lead to a dramatically decreased population of defects within the tube walls and result in the observation of near-band-edge (NBE) emission at room temperature.
On-chip Programmable Capture for Accurate Path Delay Test and Characterization (2008)

The increasing gap between modern chip frequencies and test clock frequencies provided by external test equipment, makes at-speed delay testing a challenge. We present a novel technique to generate a capture signal on-chip, with programmable delay, which enables faster than at-speed test. The test clock frequency can be programmed as a part of the test vector itself. Since test clock frequency can be controlled, it is no longer required to depend only on the long paths for detecting small delay defects, which provides flexibility in selecting test paths. The technique has minimal overhead in terms of area and design effort and can be easily incorporated into the current scan based delay test methods.
Run-time checking in Lisp by integrating memory addressing and range checking (1989)

This paper describes the BL addressing mode and the address tag in FLATS2 machine, which is a general-purpose MIMD computer now under construction. The BL addressing mode integrates memory accessing and range checking by hardware. Address tag is a bit in word, which indicates the capability for memory access. Combining them together, efficient memory protection is provided at run-time. It reduces the cost of run-time type checking in Lisp by checking the address tag and the address of a pointer against the range of the region associated to a type, in parallel with the memory access. The arithmetic instructions check the address tags of operands to support the generic arithmetic in Lisp. We can also make use of this scheme to check the number of arguments and multiple return values and to check array-bounds to support faster execution of Common Lisp program. These facilities are not specific to Lisp, so that they can be used more generally than other tagged architectures.
ATP-Binding and Hydrolysis in Inflammasome Activation (2020)

The prototypical model for NOD-like receptor (NLR) inflammasome assembly includes nucleotide-dependent activation of the NLR downstream of pathogen- or danger-associated molecular pattern (PAMP or DAMP) recognition, followed by nucleation of hetero-oligomeric platforms that lie upstream of inflammatory responses associated with innate immunity. As members of the STAND ATPases, the NLRs are generally thought to share a similar model of ATP-dependent activation and effect. However, recent observations have challenged this paradigm to reveal novel and complex biochemical processes to discern NLRs from other STAND proteins. In this review, we highlight past findings that identify the regulatory importance of conserved ATP-binding and hydrolysis motifs within the nucleotide-binding NACHT domain of NLRs and explore recent breakthroughs that generate connections between NLR protein structure and function. Indeed, newly deposited NLR structures for NLRC4 and NLRP3 have provided unique perspectives on the ATP-dependency of inflammasome activation. Novel molecular dynamic simulations of NLRP3 examined the active site of ADP- and ATP-bound models. The findings support distinctions in nucleotide-binding domain topology with occupancy of ATP or ADP that are in turn disseminated on to the global protein structure. Ultimately, studies continue to reveal how the ATP-binding and hydrolysis properties of NACHT domains in different NLRs integrate with signaling modules and binding partners to control innate immune responses at the molecular level.
Hypothermia injury/cold‐induced apoptosis—evidence of an increase in chelatable iron causing oxidative injury in spite of low O <sub>2</sub> <sup>−</sup> /H <sub>2</sub> O <sub>2</sub> formation (2000)

When incubated at 4 degrees C, cultured rat hepatocytes or liver endothelial cells exhibit pronounced injury and, during earlier rewarming, marked apoptosis. Both processes are mediated by reactive oxygen species, and marked protective effects of iron chelators as well as the protection provided by various other antioxidants suggest that hydroxyl radicals, formed by classical Fenton chemistry, are involved. However, when we measured the Fenton chemistry educt hydrogen peroxide and its precursor, the superoxide anion radical, formation of both had markedly decreased and steady-state levels of hydrogen peroxide did not alter during cold incubation of either liver endothelial cells or hepatocytes. Similarly, there was no evidence of an increase in O2-/H2O2 release contributing to cold-induced apoptosis occurring on rewarming. In contrast to the release/level of O2- and H2O2, cellular homeostasis of the transition metal iron is likely to play a key role during cold incubation of cultured hepatocytes: the hepatocellular pool of chelatable iron, measured on a single-cell level using laser scanning microscopy and the fluorescent indicator phen green, increased from 3.1 +/- 2.3 microM (before cold incubation) to 7.7 +/- 2.4 microM within 90 min after initiation of cold incubation. This increase in the cellular chelatable iron pool was reversible on rewarming after short periods of cold incubation. The cold-induced increase in the hepatocellular chelatable iron pool was confirmed using the calcein method. These data suggest that free radical-mediated hypothermia injury/cold-induced apoptosis is primarily evoked by alterations in the cellular iron homeostasis/a rapid increase in the cellular chelatable iron pool and not by increased formation of O2-/H2O2.
Prestack poststack 3D Multiple Prediction (2003)

Using stacking velocities to generate hyperbolic prestack arrivals from poststack data, a useful and truly 3D surface-related multiple prediction is made for a stacked 3D data volume. In its small-aperture limit the method reduces to autoconvolution of each stacked trace with itself.
Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function (2016)

Mutations/deletions in the SHANK3 gene are associated with autism spectrum disorders and intellectual disability. Here, we present electrophysiological and behavioral consequences in novel heterozygous and homozygous mice with a transcriptional stop cassette inserted upstream of the PDZ domain-coding exons in Shank3 (Shank3<sup>E13</sup> ). Insertion of a transcriptional stop cassette prior to exon 13 leads to loss of the two higher molecular weight isoforms of Shank3. Behaviorally, both Shank3<sup>E13</sup> heterozygous (HET) and homozygous knockout (KO) mice display increased repetitive grooming, deficits in social interaction tasks, and decreased rearing. Shank3<sup>E13</sup> KO mice also display deficits in spatial memory in the Morris water maze task. Baseline hippocampal synaptic transmission and short-term plasticity are preserved in Shank3<sup>E13</sup> HET and KO mice, while both HET and KO mice exhibit impaired hippocampal long-term plasticity. Additionally, Shank3<sup>E13</sup> HET and KO mice display impaired striatal glutamatergic synaptic transmission. These results demonstrate for the first time in this novel Shank3 mutant that both homozygous and heterozygous mutation of Shank3 lead to behavioral abnormalities with face validity for autism along with widespread synaptic dysfunction. Autism Res 2017, 10: 42-65. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.
Aircraft Ground Vibration Testing at the NASA Dryden Flight Research Facility - 1993 (1994)

The NASA Dryden Flight Research Facility performs ground vibration testing to assess the structural characteristics of new and modified research vehicles. This paper updates the research activities, techniques used, and experiences in applying this technology to aircraft since 1987. Test equipment, data analysis methods, and test procedures used for typical test programs are discussed. The data presented illustrate the use of modal test and analysis in flight research programs for a variety of aircraft. This includes a technique to acquire control surface free-play measurements on the X-31 airplane more efficiently, and to assess the effects of structural modifications on the modal characteristics of an F-18 aircraft. In addition, the status and results from current research activities are presented. These data show the effectiveness of the discrete modal filter as a preprocessor to uncouple response measurements into simple single-degree-of-freedom responses, a database for the comparison of different excitation methods on a JetStar airplane, and the effect of heating on modal frequency and damping.
Overexpression of Rho GDP-Dissociation Inhibitor Alpha Is Associated with Tumor Progression and Poor Prognosis of Colorectal Cancer (2008)

The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPases, which are essential for tumor progression, particularly in the area of metastasis. One member of GDIs was identified as RhoGDI (Rho GDP-dissociation inhibitor alpha, or RhoGDIalpha), but little is known about this protein in tumors. In this study, we used comparative proteomic analysis to show that RhoGDI is markedly up-regulated in metastatic colorectal cancer (CRC). The elevated level of RhoGDI protein in metastatic CRC was confirmed by Western blot at the tissue ( n = 24) and cell ( n = 6) levels. Further, we analyzed RhoGDI protein expression in 126 clinicopathologically characterized CRC cases by immunohistochemistry. Statistical analysis showed that there were significant differences of RhoGDI overexpression in patients categorized according to tumor invasion ( p = 0.018), lymph node metastasis ( p = 0.001) and clinical stage ( p = 0.009). A trend was also identified between high expression of RhoGDI and shorter overall survival ( p = 0.013). In the present work, we also analyzed the effect of RhoGDI on CRC cell line. Gene transfection-mediated overexpression of RhoGDI in HT29 cells, containing a low detectable level of endogenous RhoGDI, resulted in a significant increase in cell proliferation and motility in vitro. These data suggest that RhoGDI may promote CRC progression and metastasis by stimulating tumor cell growth and migration.
Bulk Ring-Opening Transesterification Polymerization of the Renewable δ-Decalactone Using an Organocatalyst (2011)

The bulk ring-opening polymerization of renewable δ-decalactone using 1,5,7-triazabicyclo[4.4.0]dec-5-ene was carried out at temperatures between 7 and 110 °C. The equilibrium monomer concentration for reactions within this temperature range was used to determine the polymerization thermodynamic parameters (Δ<i>H</i><sub>p</sub> = -17.1 ± 0.6 kJ mol<sup>-1</sup>, Δ<i>S</i><sub>p</sub> = -54 ± 2 J mol<sup>-1</sup> K<sup>-1</sup>) for δ-decalactone. The polymerization kinetics were established and high molar mass poly(δ-decalactone) was prepared with a glass transition temperature of -51 °C. Poly(δ-decalactone) samples with controlled molar mass and narrow molar mass distributions were realized by controlling the monomer conversion and initiator concentration. A high molar mass poly(lactide)-poly(δ-decalactone)-poly(lactide) triblock copolymer with a low polydispersity index was prepared by simple sequential addition of monomers. The product triblock exhibited two distinct glass transitions temperatures consistent with microphase segregation.
White-light image processing with LiNbO_3 (1980)

Iron-doped LiNbO(3) has been employed to carry out some image processing operations such as sum, difference, or multiplication of two intensity distributions. Contrast enhancement or reversal of a signal can also be obtained. The signals, modulated on low-frequency carriers, are imaged on the ferroelectric crystal, and this disposition permits the use of white light for both writing and reading the information. An advantage of our technique is that the writing of information is accomplished once and for all, and the various imageprocessing operations are carried out by suitable manipulations at the reading stage. A further advantage is that the output information can be displayed in color. The limitations on the source size and its spectralspread imposed by the finite thickness of the recording medium have been analyzed, and some experimental results are given.
Drift of an Optical Fiber Gyroscope Caused by the Faraday Effect: Experiment (1986)

The noise sources in the optical fiber gyroscope[1] must be completely estimated and eliminated for practical applications. An optical fiber gyroscope with ordinary single mode fiber used under the earth’s magnetic field shows a drift nearly equal to the earth's rotation rate through the Faraday effect[2]. It was pointed out qualitatively in the experiment that the drift can be suppressed by using a polarization maintaining fiber[3].
Raster-scan hidden surface algorithm techniques (1977)

Two new techniques are presented for reducing the number of depth calculations in hidden surface elimination. Two new algorithms using the techniques are compared with three existing algorithms and it is shown by examples that the new techniques reduce the number of multiplications involved in the depth calculations. A technique for increasing the parallelism of operations is also presented. This allows the calculation to be done more rapidly in hardware and is particularly useful for generating line drawings rather than the usual TV raster scan images in the common raster-scan hidden surface algorithms.
Viral Respiratory Disease at Lowry Air Force Base in Denver, 1952-1982 (1983)

Surveillance of febrile respiratory diseases at Lowry Air Force Base, Denver, has been maintained from 1952 to 1982 with laboratory confirmation of diagnosis. Unvaccinated recruit populations were extremely vulnerable to explosive outbreaks of influenza A. Ten controlled trials demonstrated the protective efficacy of inactivated vaccines. Recent military vaccines have raised the hemagglutination-inhibiting antibody levels of most persons into the "protective" range. Despite repeated introduction of influenza viruses onto the base, when all personnel were vaccinated the impact of influenza was reduced to an insignificant level except in one year of antigenic shift (1968) and one of major antigenic drift (1972). Adenovirus disease has been virtually eliminated since live oral types 4 and 7 vaccines have been given to incoming recruits. Rubella and rubeola have disappeared since seronegative recruits have received vaccine. Overall rates of febrile respiratory diseases have been greatly reduced.
Internet Key Exchange Protocol: IKEv2 (2008)

This document describes version 2 of the Internet Key Exchange (IKE)
protocol. It is a restatement of RFC 4306, and includes all of the
clarifications from RFC 4718.
Berg Balance Scale and Functional Reach: determining the best clinical tool for individuals post acute stroke (2004)

Subjects' performance on the Berg Balance Scale was closely associated with performance on the Functional Reach. Therefore, the clinician may elect to use the shorter Functional Reach as a measure of balance where efficient use of time is the primary goal.