gebhart/patrepeval huggingface dataset:
The synovial cadherin (cadherin-11) promotes intercellular motility (2007)

Background IL-21 is secreted by activated T cells and modulates immune cell functions with both proinflammatory and anti-inflammatory effects. IL-21 receptor (IL-21R), homologous to IL-2R and IL-4R, associates with the gamma common chain upon ligand binding. It was recently described that IL-21R is overexpressed in the inflamed synovial membrane and on leucocytes of rheumatoid arthritis patients. Objective Previously we have shown that blockade of the IL-21 pathway with soluble IL-21R-Fc resulted in a reduction of clinical signs of arthritis in rodent models. To understand potential mechanisms of IL-21 regulation in arthritis, we analyzed serum immunoglobulin levels, and cytokine expression in the paws, serum, and collagen-restimulated splenocytes, in response to IL-21 pathway blockade. Methods Arthritis was induced in DBA/1 male mice with bovine type II collagen. Animals were treated with either soluble mIL-21R-Fc, which neutralizes murine IL-21 bioactivity, with TNFRII-Fc or with control IgG. Spleens from each group of treated mice were cultured in vitro with collagen and assayed for cytokine secretion. Cytokines and anticollagen-specific IgG levels were also measured in the serum by ELISA. Cytokine mRNA levels in the paws were evaluated by quantitative PCR analysis. Results Treatment of mice with IL-21R-Fc or TNFRII-Fc reduced clinical and histological signs of collagen-induced arthritis. IL-6 mRNA in paws and serum IL-6 levels were decreased after IL-21R-Fc treatment. IFN mRNA was increased in paws of IL-21R-Fctreated mice. Collagen-specific spleen cell responses from IL-21R-Fc-treated mice exhibited increased IFN and IL-2, and reduced IL-6 and IL-17 levels. Serum levels of total IgG 1 were also reduced in response to IL-21R-Fc treatment. Conclusion These data demonstrate a role for IL-21 in the modulation of collagen-specific T-cell responses and the pathology of arthritis, supporting a rationale for blockade of the IL-21 pathway in rheumatoid arthritis.
G. H. von Wright. On probability. Mind, n.s. vol. 49 (1940), pp. 265–283. (1940)

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High performance coatings: in situ surface modification with zircoaluminate metallo organic coupling agents (1988)

Zircoaluminate metallo organics constitute a unique family of surface modification agents which are cost effective in irreversibly modifying all inorganic fillers/pigments, carbon black, and many organic pigments. Direct in situ addition to coating resin or solvent (at 0.5–1.5 phf) will result in pronounced viscosity reduction (50.95%), reduced settling and particulate agglomeration, and improved colour strength and opacity. Zircoaluminates also improve salt spray resistance, enhance adhesion to metal substrates and eliminate telegraphing.
Precise control of small displacements of a stacked piezoelectric actuator by means of layer-by-layer driving (2002)

This paper describes a stacked (multilayered) piezoelectric (PE) actuator in which both small and large displacements can be generated with a high degree of accuracy. This operation is achieved by driving the individual layers of the multilayered PE actuator. Such multilayered actuators are sandwich-structured, with a thin, (/spl sim/50 /spl mu/m) electrode layer between each pair of thin (/spl sim/100 /spl mu/m) PE-ceramic layers, so driving an individual layer of the stacked PE actuator was difficult. This difficulty was overcome by using polyamide deposition and a YAG-laser process so that each layer had an individual connection to the power supply. Each layer of the present multilayered PE actuator is thus driven by a corresponding pair of electrodes, and each pair of electrodes can be individually controlled.
Can PET/CT replace separate diagnostic CT for cancer imaging? Optimizing CT protocols for imaging cancers of the chest and abdomen. (2007)

Stage-adapted treatment in oncology relies on correct tumor staging for patients with malignant diseases. To ensure accurate assessment of the tumor stage in thoracic and abdominal diseases by PET/CT, both CT and PET need to be optimized. In this setting, different malignant diseases require customized imaging protocols. Although in the clinical setting of therapy assessment, PET/CT with integration of low-dose, nonenhanced CT may be sufficient, tumor staging may require a more sophisticated CT protocol. This review focuses on potential CT protocols for imaging cancers of the chest and abdomen. Examples of CT protocols are presented and discussed for non-small cell lung cancer, breast cancer, colorectal cancer, gastrointestinal stromal tumors, and interventional liver therapy.
When to List, Who Should List, and How: The Capabilities Approach, Democratic Education, and Inclusion (2011)

Tony DeCesare undertakes an important project in his essay by conceptualizing a possible “middle ground” capabilities approach that intersects with the goals of democratic education. It is in light of his concern for social discussion and “the work of public reasoning” that he looks to Amartya Sen’s express avoidance of a prescribed and fixed capabilities list; to list, we understand, is to universalize and impose a view of the good in educational contexts that demand a much more localized and context-specific account of valued ends and thus capabilities.
Long-term Preservation of Cone Photoreceptors and Restoration of Cone Function by Gene Therapy in the Guanylate Cyclase-1 Knockout (GC1KO) Mouse (2011)

The authors demonstrate for the first time that long-term therapy (∼1 year) is achievable in a mammalian model of GC1 deficiency. These data provide additional justification for the development of an AAV-based gene therapy vector for the clinical treatment of Leber congenital amaurosis-1.
Review article: nitric oxide from dysbiotic bacterial respiration of nitrate in the pathogenesis and as a target for therapy of ulcerative colitis (2008)

The prolonged production of bacterial NO with sulphide can explain the initiation and barrier breakdown, which is central to the pathogenesis of UC. Therapies to alter bacterial nitrate respiration and NO production need to evolve. The production of NO by colonic bacteria and that of the mucosa need to be separated to pinpoint the sequential nature of NO damage in UC.
A critical survey of considerations in maintaining process continuity during voltage dips while protecting motors with reclosing and bus-transfer practices (1992)

Plantwide shutdowns can be avoided where voltage dips of short duration on the power distribution system are a primary cause. A voltage dip where contactors drop open and reclose can be very serious because of the nature of motors and their driven loads during voltage transients. The general nature of the problem and criteria for safe reclosing or transfer of several motors on the same bus are presented. The mathematical development and modeling techniques for induction and synchronous motors are indicated, and simple easy-to-use expressions are given for determining the currents and torques due to out-of-phase reclosing. Various protective schemes against out-of-phase reclosing and transfer, as well as methods of riding through voltage dips, are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Understanding and Overcoming Biases in Customer Reviews (2016)

Our paper contributes to the literature recommending approaches to make online reviews more credible and representative. We analyze data from four diverse major online retailers and find that verified customers who are prompted (by an email) to write a review, submit, on average, up to 0.5 star higher ratings than self-motivated web reviewers. Moreover, these email-prompted reviews remain stable over time, whereas web reviews exhibit a downward trend. This finding provides support for the existence of social influence and selection biases during the submission of a web review, when social signals are being displayed. In contrast, no information about the current state of the reviews is displayed in the email promptings. Moreover, we find that when a retailer decides to start sending email promptings, the existing population of web reviewers is unaffected both in their volume as well as the characteristics of their submitted reviews. We explore how our combined findings can suggest ways to mitigate various biases that govern online review submissions and help practitioners provide more credible, representative and higher ratings to their customers.
The subcellular organization of itaconate biosynthesis in Aspergillus terreus (1991)

A novel assay method for cis-aconitate decarboxylase (EC 4.1.1.6) has been developed. Differential centrifugation of cell-free extracts of Aspergillus terreus prepared by Novozyme treatment/nitrogen cavitation of itaconate-producing mycelia has shown that cis-aconitate decarboxylase, a key enzyme of itaconate biosynthesis, is localized exclusively in the cytosol. The intracellular localization and maximal activities of nine other enzymes putatively involved in itaconate biosynthesis were examined under both producing and non-producing growth conditions. Two striking differences between growth and production mycelia were observed: (a) cis-aconitate decarboxylase was absent from growing mycelia, and (b) aconitase activity was increased at least two-fold in production mycelia. No significant variations in the maximal activities or intracellular localization were observed for the other enzymes investigated. Mitochondrial and cytosolic isoenzymes of NADP:isocitrate dehydrogenase and malate dehydrogenase were detected by cellulose acetate strip electrophoretic analysis, whereas this analysis detected only single isoenzymes of aconitase and citrate synthase. We therefore propose that in itaconate accumulation cis-aconitate is synthesized in the mitochondrion and then transported to the cytosol where it is converted to itaconate by cis-aconitate decarboxylase.
Visible Light Emission from the Silicon-Doped SiO<sub>2</sub> Thin Film Deposited by Sputtering (1995)

Visible light emission strong enough to be seen with the naked eye was obtained at room temperature from the Si-doped SiO 2 thin films deposited on Si substrates by cosputtering of Si and SiO 2 when they were annealed in Ar at high temperature. The luminescence model with radiative recombination centers at the surface of a Si nanocrystal and nonradiative recombination centers in SiO 2 has been developed to explain the results of the combined x-ray diffraction and photolumines cence measurements.
CoHOG: A Light-Weight, Compute-Efficient, and Training-Free Visual Place Recognition Technique for Changing Environments (2020)

This letter presents a novel, compute-efficient and training-free approach based on Histogram-of-OrientedGradients (HOG) descriptor for achieving state-of-the-art performance-per-compute-unit in Visual Place Recognition (VPR). The inspiration for this approach (namely CoHOG) is based on the convolutional scanning and regions-based feature extraction employed by Convolutional Neural Networks (CNNs). By using image entropy to extract regions-of-interest (ROI) and regional-convolutional descriptor matching, our technique performs successful place recognition in changing environments. We use viewpointand appearance-variant public VPR datasets to report this matching performance, at lower RAM commitment, zero training requirements and 20 times lesser feature encoding time compared to state-of-the-art neural networks. We also discuss the image retrieval time of CoHOG and the effect of CoHOG's parametric variation on its place matching performance and encoding time.
Kalifornianripsiäisen (Frankliniella occidentalis) hallinta torjunta-aineiden käytön minimoivassa leikkoruusutuotannossa (1997 99) (2001)

Kalifornianripsiäisen torjuntaa leikkoruusulla pyrittiin tehostamaan seuraavilla tavoilla: (1) tutkimalla ripsiäisten biologiaa; (2) tutkimalla Amblyseius cucumeris -ripsiäispetopunkkien yhteiskäyttöä kasvualustassa saalistavien Hypoaspis-petopunkkien ja kasvualustan kemiallisten käsittelyjen kanssa; (3) testaamalla kasvinsuojeluaineiden sivuvaikutuksia hyötyeliöihin. Tutkimus osoitti, että aikuisten ja toukkien suhteellinen jakautuminen kukkien ja lehtien välille voidaan ennustaa avonaisten kukkien osuuden perusteella. Leikkoruusulla kr:t koteloituvat aina kasvualustaan. Siitä huolimatta Hypoaspis- ja A. cucumeris -petopunkkien yhteiskäyttö ei tehostanut ripsiäistorjuntaa kuin marginaalisesti. Amblyseiukset toimivat tehokkaammin kivivillasäkkipedeissä kuin avoturvepedeissä kasvavilla ruusuilla johtuen ripsiäisten huonommista koteloitumisolosuhteista kivivillasäkkipedeissä. Kesällä A. cucumeriksen pussilevitykset Escimo-leikkoruusun pystyversoille (4500-7000 kpl/m2/4 kk) pitivät kokonaiskukkasadon yli 90 %:sti myyntikelpoisena. Biologisen ripsiäisten ennakkotorjunnan hinnaksi tuli 5,3 mk/m2/v (225 kpl/m2 4-6 viikon välein/8 kk). Kun tähän lisättiin kesän suuret käyttömäärät, hinta oli 14,5 mk/m2/v. Pelkät A. cucumeris-petopunkkien hankintakustannukset olivat siten 2-4 -kertaa suuremmat kuin leikkoruusun kemiallisen kasvinsuojelun kokonaiskustannukset (3-4 mk/m2 ilman työkustannuksia). Tammi-huhtikuussa A. cucumerikset levisivät ruusukasvuston taivutettuun osaan ripustetuista pusseista kasveille huonosti. Tehokkaampien ja taloudellisempien ripsiäispetopunkkien löytämiseksi on tutkittava eri petopunkkilajien biologiaa ja käyttäytymistä leikkoruusulla sekä petojen käyttäytymisen manipulointimahdollisuuksia, jotta ne asuttaisivat kukinnot nopeammin. Etanolipohjaiset hiililannoiteruiskutukset olivat vaarattomia ansaripetopunkeille (Phytoseiulus persimilis), ripsiäispetopunkeille ja jauhiaiskiilukaiselle (Encarsia formosa). Ripsiäiskemikaali fiproniili lopetti A. cucumeris -naaraiden muninnan viikoksi. Kalifornianripsiäisten esikoteloiden fiproniilialtistus ei ollut tappava, mutta heikensi kuoriutuvien aikuisten kuntoa. Kivivillasäkkipetien viikottaiset fiproniilikäsittelyt alensivat ripsiäisten määrää kasveilla vasta 3 viikon kuluttua käsittelyjen alkamisesta.
Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia (2010)

DXP 1 mg and 3 mg administered nightly to elderly chronic insomnia patients for 12 weeks resulted in significant and sustained improvements in most endpoints. These improvements were not accompanied by evidence of next-day residual sedation or other significant adverse effects. DXP also demonstrated improvements in both patient- and physician-based ratings of global insomnia outcome. The efficacy of DXP at the doses used in this study is noteworthy with respect to sleep maintenance and early morning awakenings given that these are the primary sleep complaints of the elderly. This study, the longest placebo-controlled, double-blind, polysomnographic trial of nightly pharmacotherapy for insomnia in the elderly, provides the best evidence to date of the sustained efficacy and safety of an insomnia medication in older adults.
Modeling of VSC-HVDC and control strategies for supplying both active and passive systems (2006)

An equivalent continuous-time state-space model for VSC-HVDC in the synchronous dq reference frame has been established in the paper. Based on the model, relevant control strategies have been developed for the cases of supplying active and passive systems. The multi-input multi-output (MIMO) control schemes are emphasized in designing power controller and voltage controller. The scheme features feed forward compensation to decouple the d- and q-axis of the voltage source converter (VSC) model, which ensures the independent control of active and reactive power, DC voltage and reactive power as well. Simulations have been performed on PSCAD/EMTDC, a visual design environment for power system studies. The validity of the mathematic model and the feasibility of the control strategies have been proved by the simulation results.
Polypeptides of the nuclear envelope (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolypeptides of the nuclear envelopeRobert C. JacksonCite this: Biochemistry 1976, 15, 25, 5641–5651Publication Date (Print):December 1, 1976Publication History Published online1 May 2002Published inissue 1 December 1976https://pubs.acs.org/doi/10.1021/bi00670a033https://doi.org/10.1021/bi00670a033research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Successful treatment of a congenital extra-truncal vascular malformation by orally administered propranolol (2013)

Abstract The β-blocker propranolol has become a valuable and effective drug for the treatment of infantile hemangiomas. Its therapeutic action probably results from vasoconstriction, blocking of angiogenesis through effects on vascular endothelial growth factor and induction of apoptosis. It is reasonable to suggest that propranolol can also be used effectively in the treatment of other vascular abnormalities. This case report describes propranolol treatment of vascular malformations such as Klippel-Trénaunay syndrome or Parkes-Weber syndrome in adults.
Localization of human intestinal defensin 5 in Paneth cell granules (1997)

Antibiotic peptides of higher animals include the defensins, first discovered in phagocytic cells but recently also found to be produced by epithelial cells. We biosynthesized recombinant human intestinal defensin 5 (rHD-5) using the baculovirus-insect cell expression system. Since insect cells process defensin incompletely and secrete the precursor proHD-5, we substituted a methionine for an alanine at a likely processing site to allow selective chemical cleavage with cyanogen bromide, and rHD-5 was used to elicit polyclonal antibodies. By the immunoperoxidase-staining technique, the antibodies selectively stained Paneth cells of the normal adult small intestine. Immunogold electron microscopy further localized HD-5 to the Paneth cell secretory granules. Since some defensins exert activity cytotoxic to mammalian cells, we assayed the effect of rHD-5 on the human intestinal cell lines Caco2 and Int407. proHD-5 did not exert cytotoxic activity, and rHD-5 showed only minimal activity against Int407 and was inert against Caco2. Since Paneth cells release their granules adjacent to the mitotic cells of the intestinal crypts, HD could protect this cell population against invasion and parasitization by microbes.
Complex <i>N</i>‐glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments (2002)

The transmembrane glycoprotein nicastrin is a component of presenilin (PS) protein complex that is involved in gamma-cleavage of beta APP and site-3 cleavage of Notch. PS undergoes endoproteolysis, and the proteolytic fragments are incorporated into the high molecular weight protein complexes that are highly stabilized. Here we show that Endo H-resistant, N-glycosylated form of nicastrin (p150-NCT) is highly stabilized and selectively bound to PS fragments. Moreover, loss-of-function mutations of nicastrin inhibited formation of fully glycosylated p150-NCT as well as stabilization of nicastrin, suggesting that glycosylation and stabilization of nicastrin polypeptides are tightly correlated with its function.
Grassmann Clustering (2006)

Publication in the conference proceedings of EUSIPCO, Florence, Italy, 2006
Metal complex formation with 1,10-diaza-4,7,13,16-tetraoxacyclooctadecane-N,N'-diacetic acid. An approach to potential lanthanide ion selective reagents (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal complex formation with 1,10-diaza-4,7,13,16-tetraoxacyclooctadecane-N,N'-diacetic acid. An approach to potential lanthanide ion selective reagentsC. Allen Chang and Michael E. RowlandCite this: Inorg. Chem. 1983, 22, 26, 3866–3869Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/ic00168a010https://doi.org/10.1021/ic00168a010research-articleACS PublicationsRequest reuse permissionsArticle Views359Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Semiconductor Liquid Junction Solar Cell Based on Chemically Deposited Bi2 S 3 Thin Film and Some Semiconducting Properties of Bismuth Chalcogenides (1982)

The photoelectrochemical behavior of chemically deposited thin film in aqueous solution is studied. This paper also describes the dependence of the deposition of bismuth chalcogenides on the pH of the solution. The electrical resistance, mobility, and carrier concentration of bismuth chalcogenides have been measured. Optical absorption spectra reveal the bandedges which are 1.47 and 0.35 eV for and , respectively. The activation energy of electrical conduction of obtained is ∼0.9 eV.