gebhart/patrepeval huggingface dataset:
On the Kinetics of Crystallization of Polymers from Stirred Solutions (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the Kinetics of Crystallization of Polymers from Stirred SolutionsA. J. Pennings and M. F. J. PijpersCite this: Macromolecules 1970, 3, 2, 261–262Publication Date (Print):March 1, 1970Publication History Published online1 May 2002Published inissue 1 March 1970https://pubs.acs.org/doi/10.1021/ma60014a026https://doi.org/10.1021/ma60014a026research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of cathepsin D and epidermal growth factor receptor in prostate carcinoma. (1994)

Differential reactivity for cathepsin D (cath-D) and epidermal growth factor receptor (EGFR) was compared in 102 archival cases of human primary prostatic carcinoma and nine prostate carcinoma metastases by immunohistochemical techniques using commercially available antibodies (Ciba-Corning, Triton Diagnostics Division, Alameda, CA). Western immunoblotting confirmed that the anti-cath-D and anti-EGFR antibodies recognized the appropriate-sized proteins in extracts of human prostatic carcinoma cell lines. For immunohistochemical analysis, the primary prostate carcinomas ranged from Gleason's combined scores of 2 to 9. High-grade prostatic intraepithelial neoplasia was coexistent in 79 of the cases. Immunohistochemical staining was scored by summing the intensity of staining (0 to 3+) weighted by the percentage of tumor staining at each intensity (H score, theoretical range 0 to 300). Heterogenous moderate to strong reactivity with anti-cath-D was detected in 96 of 102 cases of primary prostate carcinoma (94%), with a mean H score of 176.5. EGFR reactivity was much less common and less strong, with 41 of 102 primary prostate carcinomas staining (40%) at a mean H score intensity of 29.2. The immunohistochemical (H) scores of cath-D and EGFR reactivity both significantly correlated with the Gleason's combined score of the tumors. There was no significant correlation between the cath-D and EGFR scores. Ninety-nine percent of the examples of prostatic intraepithelial neoplasia were reactive with anti-cath-D, with no clear correlation between the intensity of staining of prostatic intraepithelial neoplasia and the adjacent carcinoma.(ABSTRACT TRUNCATED AT 250 WORDS)
Revaluations, V: F. S. Oliver, “Alexander Hamilton: an Essay on American Union” (1959)

The writings of F. S. Oliver arouse as little interest today as the causes he espoused: tariff reform, the rights of Ulster, military preparedness, Imperial unity are issues abandoned by Politics but unclaimed by History. Booksellers indifferently expose his works to the elements. It is true that a brief account of his career is to be found in the Dictionary of National Biography ; but the third volume of the Cambridge History of the British Empire does not mention his name. Yet to his contemporaries Oliver was a figure of great significance and the decline of his reputation has been swift and startling. Reasons can be put forward to account for the change: his political tracts are no longer relevant, his historical works were the efforts of an amateur in a discipline which has become increasingly professional, and his influence was always based primarily upon the force of his personality and the charm of his correspondence. Oliver's singular position in public affairs both helped and hindered his influence. Business preoccupations and indifferent health excluded him from an active part in politics, or so it is said. Doubt on this point is perhaps permissible, since the decade before 1914 saw him active in discussion and prolific as an author. It seems more likely that these were excuses offered to conceal his inability to accept the conventions of democracy. Walpole and Hamilton, Oliver's two heroes, marked the bounds of his political beliefs: the wider world of manhood suffrage was not for him.
G2/M Arrest by 1,25-Dihydroxyvitamin D3 in Ovarian Cancer Cells Mediated through the Induction of GADD45 via an Exonic Enhancer (2003)

1,25-Dihydroxyvitamin D3 suppresses the growth of multiple human cancer cell lines by inhibiting cell cycle progression and inducing cell death. The present study showed that 1,25-dihydroxyvitamin D3 causes cell cycle arrest at the G2/M transition through p53-independent induction of GADD45 in ovarian cancer cells. Detailed analyses have established GADD45 as a primary target gene for 1,25-dihydroxyvitamin D3. A DR3-type vitamin D response element was identified in the fourth exon of GADD45 that forms a complex with the vitamin D receptor.retinoid X receptor heterodimer in electrophoresis mobility shift assays and mediates the dose-dependent induction of luciferase activity by 1,25-dihydroxyvitamin D3 in reporter assays. Chromatin immunoprecipitation assays have shown that the vitamin D receptor is recruited in a ligand-dependent manner to the exonic enhancer but not to the GADD45 promoter regions. In ovarian cancer cells expressing GADD45 antisense cDNA or GADD45-null mouse embryo fibroblasts, 1,25-dihydroxyvitamin D3 failed to induce G2/M arrest. Taken together, these results identify GADD45 as an important mediator for the tumor-suppressing activity of 1,25-dihydroxyvitamin D3 in human ovarian cancer cells.
The preparation of tritium labelled biocompatible polymers (1993)

Abstract The preparation of tritiated phosphoryl choline containing linear polymers by the reduction of an acetylenically unsaturated polymer with tritium gas is described. Homogeneous catalysis was used and the product was analysed by 1 H and 3 H‐nmr spectroscopy. The use of lanthanide shift reagents showed that 98% of the isotope was located in the 7 and 8 positions of the hydrophobic chains.
Effect of antioxidants in experimental Escherichia coli septicemia. (1989)

Free radicals have been implicated in the pathogenesis of gram-negative bacterial sepsis. We assessed the effectiveness of antioxidants and chelators to alter oxidative injury in established severe experimental Escherichia coli septicemia. One hour after challenge by intraperitoneal injection of bacteria, 36 rabbits were treated with moxalactam and randomized in sets of three to receive either placebo, superoxide dismutase (SOD), or a combination of antioxidants and chelators consisting of SOD, sodium thiosulfate, alpha-tocopherol, deferoxamine, and diethyldithiocarbamate. Throughout the course of treatment, levels of bacteremia and endotoxemia were similar among the three experimental groups. Neither antioxidant-treated group was significantly different from the control group in mean arterial blood pressure, leukocyte count, platelet count, core temperature, blood lactate, oxygenation or survival. Arterial pH and [HCO3-] were significantly lower in the antioxidant combination group compared to the control and SOD groups (P less than .01). In this model, antioxidant and chelator therapy does not substantially ameliorate established septicemia.
Water-Distribution Systems Simplifications through Clustering (2011)

For large water-distribution systems fully detailed models result in a substantial amount of data, making it difficult to manage, monitor, and understand how the main structure of the system works. A possible way to cope with this difficulty is to gain insight to the system behavior by simplifying its operation through topological/connectivity analysis. The objective of this study is to develop and demonstrate a generic topological-based scheme to aid in the analysis of water-distribution systems. The methodology relies on clustering, which divides the distribution system into strongly and weakly connected sub-graphs using the depth first search (DFS) and breadth first search (BFS) graph algorithms. The partitioning results in a connectivity matrix that represents the interconnections between clusters, which can support, for example, a response modeling plan in case of a contamination intrusion incident. A detailed illustrative example and a real complex water-distribution system are explored for demonstrating the developed model capabilities. Possible applications of the proposed algorithm are suggested.
Phase I Trial of Concurrent Twice-Weekly Recombinant Human Interleukin-12 Plus Low-Dose IL-2 in Patients With Melanoma or Renal Cell Carcinoma (2003)

The addition of concurrent low-dose IL-2 to rhIL-12 is well tolerated, restores and maintains immune activation by rhIL-12, and has clinical activity. This regimen should be further investigated in phase II studies in untreated patients with melanoma or renal cell cancer and in other rhIL-12-responsive malignancies.
Surface engineering of biomaterials with plasma techniques (2003)

In this study, 3 types of plasma techniques, i.e. plasma modification, plasma deposition and plasma followed by grafting reaction, are used for the fabrication of tools, medical devices and biomaterials. Depending on purpose, bioadhesion of cells and biomolecules is either looked for or avoided. Since the mechanisms of bioadhesion depend on the characteristics of the surface (hydrophilic or hydrophobic), modifying the surface by a treatment will alter the bioadhesion. These treatments are developed for the anti-fouling process, the sterilisation and the improvement of the formation of biofilms. They have also proved useful for the synthesis of biomimicking devices.
Symbol Error Probabilities for M-ary CPFSK: Coherent and Noncoherent Detection (1976)

Continuous-phase frequency shift keying (CPFSK) is discussed and theoretical predictions for symbol error probabilities are derived, where the memory inherent in the phase continuity is used to improve performance. Previously known results concluded that binary CPFSK can outperform coherently detected PSK at high SNR. New results presented here show that <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</tex> -ary CPFSK outperforms more tranditionally used <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</tex> -ary modulation systems. Specifically, coherently detected quaternary CPFSK with a five-symbol interval decision can outperform coherent QPSK by 3.5 dB, and octal coherent CPFSK with a three- symbol decision can outperform octal orthogonal signaling by 2.6 dB at high SNR. Results for coherently detected and noncoherently detected CPFSK are derived. These performance improvements are estimates derived from symbol error probability upper bounds. Monte Carlo simulation was performed which then verified the results.
Akt/Protein Kinase B Activation by Adenovirus Vectors Contributes to NFκB-Dependent CXCL10 Expression (2005)

In gene therapy, the innate immune system is a significant barrier to the effective application of adenovirus (Ad) vectors. In kidney epithelium-derived (REC) cells, serotype 5 Ad vectors induce the expression of the chemokine CXCL10 (IP-10), a response that is dependent on NFkappaB. Compared to the parental vector AdLuc, transduction with the RGD-deleted vector AdL.PB resulted in reduced CXCL10 activation despite increasing titers, implying that RGD-alpha(V) integrin interactions contribute to adenovirus induction of inflammatory genes. Akt, a downstream effector of integrin signaling, was activated within 10 min of transduction with Ad vectors in a dose-dependent manner. Akt activation was not present following transduction with AdL.PB, confirming the importance of capsid-alpha(V) integrin interactions in Ad vector Akt activation. Inhibition of the phosphoinositide-3-OH kinase/Akt pathway by Wortmannin or Ly294002 compounds decreased Ad vector induction of CXCL10 mRNA. Similarly, adenovirus-mediated overexpression of the dominant negative AktAAA decreased CXCL10 mRNA expression compared to the reporter vector AdLacZ alone. The effect of Akt on CXCL10 mRNA expression occurred via NFkappaB-dependent transcriptional activation, since AktAAA overexpression and Ly294002 both inhibited CXCL10 and NFkappaB promoter activation in luciferase reporter experiments. These results show that Akt plays a role in the Ad vector activation of NFkappaB and CXCL10 expression. Understanding the mechanism underlying the regulation of host immunomodulatory genes by adenovirus vectors will lead to strategies that will improve the efficacy and safety of these agents for clinical use.
Analysis of the CD151·α3β1 Integrin and CD151·Tetraspanin Interactions by Mutagenesis (2001)

Transmembrane proteins of the tetraspanin superfamily are associated with various integrins and modulate their function. We performed mutagenesis analysis to establish structural requirements for the interaction of CD151 with the alpha3beta1 integrin and with other tetraspanins. Using a panel of CD151/CD9 chimeras and CD151 deletion mutants we show that the minimal region, which confers stable (e.g. Triton X-100-resistant) association of the tetraspanin with alpha3beta1, maps within the large extracellular loop (LECL) of CD151 (the amino acid sequence between residues Leu(149) and Glu(213)). Furthermore, the substitution of 11 amino acids (residues 195-205) from this region for a corresponding sequence from CD9 LECL or point mutations of cysteines in the conserved CCG and PXXCC motifs abolish the interaction. The removal of the LECL CD151 does not affect the association of the protein with other tetraspanins (e.g. CD9, CD81, CD63, and wild-type CD151). On the other hand, the mutation of the CCG motif selectively prevents the homotypic CD151-CD151 interaction but does not influence the association of the mutagenized CD151 with other tetraspanins. These results demonstrate the differences in structural requirements for the heterotypic and homotypic tetraspanin-tetraspanin interactions. Various deletions involving the small extracellular loop and the first three transmembrane domains prevent surface expression of the CD151 mutants but do not affect the CD151-alpha3beta1 interaction. The CD151 deletion mutants are accumulated in the endoplasmic reticulum and redirected to the lysosomes. The assembly of the CD151-alpha3beta1 complex occurs early during the integrin biosynthesis and precedes the interaction of CD151 with other tetraspanins. Collectively, these data show that the incorporation of CD151 into the "tetraspanin web" can be controlled at various levels by different regions of the protein.
Thermal barrier coating materials (2005)

Improved thermal barrier coatings (TBCs) will enable future gas turbines to operate at higher gas temperatures. Considerable effort is being invested, therefore, in identifying new materials with even better performance than the current industry standard, yttria-stabilized zirconia (YSZ). We review recent progress and suggest that an integrated strategy of experiment, intuitive arguments based on crystallography, and simulation may lead most rapidly to the development of new TBC materials.
Einführung (2004)

Nachdem zunächst die USA und später Europa den Luftverkehr liberalisiert hatten und damit die Branche begann, sich neu zu ordnen, wandten sich auch die Wirtschaftswissenschaften verstärkt der Luftverkehrswirtschaft zu. Die besonderen Aspekte der Luftfahrt erfordern eine spezifische Betrachtung dieser Branche. Die Strategieentwicklung ist durch sehr langfristige Investitionen mit hohem Kapitaleinsatz geprägt, so dass es besonders wichtig ist, frühzeitig mögliche künftige Entwicklungen in den Unternehmen und im Umfeld zu berücksichtigen. Gleichzeitig ist die Branche stark abhängig von externen Schocks. Diskontinuitäten zu Beginn des 21. Jahrhunderts wie beispielsweise der Irakkrieg, die wirtschaftliche Flaute in einer Reihe von Ländern ab 2001 oder die Ereignisse des 11. September 2001 resultierten in heftigen Turbulenzen und Krisen im Luftverkehr. Sie zeigen die Bedeutung angemessener vorausschauender Strategien.1 Den mit Abstand wichtigsten und am stärksten von externen Schocks abhängigen Bereich des Luftverkehrs bilden dabei die Passagierfluggesellschaften.
<i>Drosophila</i> Regnase-1 RNase is required for mRNA and miRNA profile remodelling during larva-to-adult metamorphosis (2019)

Metamorphosis is an intricate developmental process in which large-scale remodelling of mRNA and microRNA (miRNA) profiles leads to orchestrated tissue remodelling and organogenesis. Whether, which, and how, ribonucleases (RNases) are involved in the RNA profile remodelling during metamorphosis remain unknown. Human Regnase-1 (also known as MCPIP1 and Zc3h12a) RNase remodels RNA profile by cleaving specific RNAs and is a crucial modulator of immune-inflammatory and cellular defence. Here, we studied <i>Drosophila</i> CG10889, which we named <i>Drosophila</i> Regnase-1, an ortholog of human Regnase-1. The larva-to-adult metamorphosis in <i>Drosophila</i> includes two major transitions, larva-to-pupa and pupa-to-adult. <i>regnase-1</i> knockout flies developed until the pupa stage but could not complete pupa-to-adult transition, dying in puparium case. Regnase-1 RNase activity is required for completion of pupa-to-adult transition as transgenic expression of wild-type <i>Drosophila</i> Regnase-1, but not the RNase catalytic-dead mutants, rescued the pupa-to-adult transition in <i>regnase-1</i> knockout. High-throughput RNA sequencing revealed that <i>regnase-1</i> knockout flies fail to remodel mRNA and miRNA profiles during the larva-to-pupa transition. Thus, we uncovered the roles of <i>Drosophila</i> Regnase-1 in the larva-to-adult metamorphosis and large-scale remodelling of mRNA and miRNA profiles during this metamorphosis process.
Optimization of signal propagation performances in interconnects of the 45 nm node by exhaustive analysis of the technological parameters impact (2005)

Due to the continuous shrink of technology dimensions, parasitic propagation delay time and crosstalk at interconnect levels increasingly affect overall circuit performances. New materials, processes and architectures are now required to improve BEOL performances. A rigorous high-frequency electromagnetic approach including the scattering effects on Cu line resistance was developed for coupled narrow interconnects to analyze the actual benefits of these innovations for different signal types covering application range from logic to I/O. Effects of advanced metallization (ALD thin barriers), low-k insulators (porous ULKs, low-k barriers), and innovative architectures (hybrid stacks, air gaps, self-aligned barriers) on signal propagation performance were quantified, resulting in an effective process selection for the 45 nm technological node and below.
Atomic Friction Studied by Modeling the Buried Inteface (2011)

Molecular dynamics simulation is carried out to model the single-asperity friction in atomic force microscope experiments. Superlubricity is achieved through misalignment between the AFM tip and substrate. Direct observation of the buried interface reveals that incommensurability-induced inhomogeneous shear stress can cause ultra-low atomic scale friction.
Versuchsgerätebeschreibung (1977)

Um die Festigkeit des Filterkuchens, bzw. eines Formlings zu messen, werden die Formlinge in zylindrischer Form mit den Abmessungen 15 × 10 mm ø hergestellt. Die Herstellung dieser Formlinge erfolgt durch Eindrücken von Glasröhrchen der obigen inneren Abmessungen in den Schlamm, der sich in der Filternutsche befindet, s. Bild 9. Nach Ausstoßen der Formlinge aus den Röhrchen mittels eines Stabes werden sie auf die richtigen Abmessungen abgeschliffen und anschließend auf ihre Festigkeit untersucht.
Calling all doses (2002)

Michael R. Cohen is president of the Institute for Safe Medication Practices (ISMP), a nonprofit organization that derives its reports from the USP-ISMP Medication Errors Reporting Program. To report medication errors, call the USP at 1-800-23-ERROR (233-7767). You can reach the ISMP at 215-947-7797 or via E-mail at [email protected].
Towards an Indoor Level-of-Detail Model for Route Visualization (2009)

Indoor routing represents an essential feature required by applications and systems that provide spatial information about complex sites, buildings and infrastructures such as in the case of visitor guidance for trade fairs and customer navigation at airports or train stations. Apart from up-to date, precise 3D spatial models these systems and applications need user interfaces as core system components that allow users to efficiently express navigation goals and to effectively visualize routing information. For interoperable and flexible indoor routing systems, common specifications and standards for indoor structures, objects, and relationships are needed as well as for metadata such as data quality and certainty. In this paper, we introduce a classification of indoor objects and structures taking into account geometry, semantics, and appearance, and propose a level-of-detail model for them that supports the generation of effective indoor route visualization.
(110) NMOSFETs competitive to (001) NMOSFETs: Si migration to create (331) facet and ultra-shallow Al implantation after NiSi formation (2008)

We demonstrated for the first time the device performance of (110) nMOSFETs featuring a Si migration process, resulting in better mobility and modified shape of the narrow active region, and ultra-shallow Al implantation after nickel silicide (NiSi) formation, resulting in reduced parasitic resistance. We found that these processes made the performance of (110) nMOSFETs competitive with that of (001) nMOSFETs while maintaining their 40% advantage in pMOSFET performance.