gebhart/patrepeval huggingface dataset:
Shaker K+ Channel T1 Domain Self-tetramerizes to a Stable Structure (1995)

The potassium channel T1 domain plays an important role in the regulated assembly of subunit proteins. We have examined the assembly properties of the Shaker channel T1 domain to determine if the domain can self-assemble, the number of subunits in a multimer, Ns and the mechanism of assembly. High pressure liquid chromatography (HPLC) size exclusion chromotography (SEC) separates T1 domain proteins into two peaks. By co-assembly assays, these peaks are identified to be a high molecular weight assembled form and a low molecular weight monomeric form. To determine the Ns of the assembled protein peak on HPLC SEC, we first cross-linked the T1 domain proteins and then separated them on HPLC. Four evenly spaced bands co-migrate with the assembled protein peak; thus, the T1 domain assembles to form a tetramer. The absence of separate dimeric and trimeric peaks of assembled T1 domain protein suggests that the tetramer is the stable assembled state, most probably a closed ring structure.
Inspection technique for cleaved optical fiber ends based on Fabry-Perot resonator (2011)

We present a novel inspection technique for cleaved optical fiber ends based on the Fabry-Perot resonator. The technique uses mainly laser diodes, an optical power meter, 3-dB coupler, and XY lateral adjustment stage. It can be achieved more easily than current imaging processing that uses a charge coupled device camera and video monitor. The inspected fiber end is considered failed or successful depending on whether both the measured return losses from the fiber end at two wavelengths are equal to ~14.7 dB. Experimentally obtained fiber end images were in good agreement with scanning electron microscope observation images. Thus, the proposed technique provides a simple and cost-effective way to inspect cleaved optical fiber ends.
Defending the forest in the clouds: Public interest law in Solomon Islands (2013)

Solomon Islands' forests have high levels of biodiversity and are an important component of the country's culture and custom. The forests are under threat due to decades of unsustainable logging. Under Solomon Islands' law, logging companies need approval from the government and the customary landowners before commencing logging. This case note summarises two cases in the Solomon Islands High Court brought by an association of landowners to protect the 'cloud forest' of Kolombangara Island. In the first case, the High Court held that the association had standing to seek an injunction to prevent a company from logging without obtaining the necessary government approvals. The second case, which has not yet been finally determined by the Court, challenges the legality of the approvals subsequently granted by the government. These cases potentially pave the way for further public interest environmental litigation in Solomon Islands.
Mixed confinement regimes during equilibrium confinement spectroscopy of DNA (2014)

We have used a combination of fluorescence microscopy experiments and Pruned Enriched Rosenbluth Method simulations of a discrete wormlike chain model to measure the mean extension and the variance in the mean extension of λ-DNA in 100 nm deep nanochannels with widths ranging from 100 nm to 1000 nm in discrete 100 nm steps. The mean extension is only weakly affected by the channel aspect ratio. In contrast, the fluctuations of the chain extension qualitatively differ between rectangular channels and square channels with the same cross-sectional area, owing to the "mixing" of different confinement regimes in the rectangular channels. The agreement between experiment and simulation is very good, using the extension due to intercalation as the only adjustable parameter.
Robust hybrid control of robot manipulators (2003)

The problem of hybrid (position and force) control of robot manipulators is studied as a control of a dynamical system whose mathematical model contains uncertainties. It is shown that robust control which renders the system globally practically stable can be designed. A simplification of the robust control can be made provided the uncertainty is cone-bounded. This occurs when the modeling error in the Coriolis and centrifugal forces is negligible. Further elaboration on the quadratically bounded uncertainty (which occurs as substantial modeling error in Coriolis and centrifugal forces arises) is investigated. The simplified robust control is shown to be applicable provided the control design parameters are chosen in a prescribed way. A control for a two-joint SCARA type robot is provided as an illustrative example. Excellent system performance is observed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
CHEMICAL N DOPING OF POLYACETYLENE (1983)

The mechanism of polyacetylene N type doping is discussed. New dopants such as alkaline carbanionic salts and tetraalkyl-ammonium salt of dianionic benzophenone are reported. Swelling studies show that polar solvent such as THF inserts reversibly in N doped (CH)x and that the driving force of this insertion is the cation solvation energy. This solvation drastically influenceselectrical conductivity (σ). At low doping level σ strongly increases by THF insertion whereas σ decreases at high doping level. Doping with diphenylhexyl-lithium was performed in non-polar solvent and σ variation with doping level is presented.
<b>Clarify</b>: Software for Interpreting and Presenting Statistical Results (2003)

Clarify is a program that uses Monte Carlo simulation to convert the raw output of statistical procedures into results that are of direct interest to researchers, without changing statistical assumptions or requiring new statistical models. The program, designed for use with the Stata statistics package, offers a convenient way to implement the techniques described in: Gary King, Michael Tomz, and Jason Wittenberg (2000).
Membrane properties in chronic inflammatory demyelinating polyneuropathy (2001)

Threshold tracking was used to compare excitability properties (stimulus-response curves, strength-duration properties, recovery cycle and threshold electrotonus) of the median nerve in 11 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and 25 healthy controls. Stimulus-response curves were significantly different: threshold was much higher, the slope of the curves reduced and the spread of the thresholds greater in the CIDP group. The strength-duration time constant (tau(SD)) was significantly shorter and the rheobase higher in the CIDP group. In the recovery cycle, the CIDP group had less refractoriness, supernormality and late subnormality than healthy controls, but the duration of the relatively refractory period was normal. These changes in tau(SD) and the recovery cycle were not those previously predicted. There were no consistent changes in threshold electrotonus, suggesting that, for the studied axons, there are no consistent changes in accommodation properties that depend on internodal conductances. It is difficult to explain these changes in excitability on the basis of a change in membrane potential, or solely as the result of demyelination, and it is possible that other morphological factors such as variable remyelination and inflammatory oedema affected axonal excitability in the patients.
Flow cytometry detection of serotonin content and release in resting and activated platelets (2003)

Early detection of platelet activation is important for the diagnosis and follow-up of several pathological conditions that primarily or secondarily involve platelets in their pathogenesis. The golden standard assay to detect thrombocyte activation is represented by the release of serotonin, classically performed by demanding methodologies, such as high-performance liquid chromatography, 14C-labelling and enzyme-linked immunosorbent assay (ELISA). We developed a non-radioactive method, based on individual cells, for the detection of serotonin content in activated and resting platelets by flow cytometry. The assay was standardized on cells activated by Ca2+ ionophore or by sera from patients with heparin-induced thrombocytopenia (HIT). Cells were identified by CD41a surface staining and their serotonin content measured by specific antiserotonin intracytoplasmic staining, while their activation was independently shown by annexin V binding. Cellular degranulation was detected by flow cytometry in all the cases that were also positive by standard ELISA. Moreover, multiparametric flow cytometry analysis revealed that, although virtually all activated cells bind annexin V, serotonin was released only by the platelet subset that downmodulates surface CD41a.
<i>N</i>-Vinylpyridinium and -ammonium Tetrafluoroborate Salts: New Electrophilic Coupling Partners for Pd(0)-Catalyzed Suzuki Cross-Coupling Reactions (2007)

N-Vinylpyridinium and -trialkylammonium tetrafluoroborate salts represent a new class of electrophilic coupling partner for Pd(0)-catalyzed Suzuki cross-coupling reactions and give very good to excellent yields of products with a wide range of boronic acids. The salts are easily prepared from activated acetylenes and pyridinium or trialkylammonium tetrafluoroborates to form crystalline, air-stable, and nonhygroscopic crystals. [reaction: see text].
YIELD AND GROWTH RESPONSE OF STRAWBERRY TO PLANT GROWTH-PROMOTING RHIZOBACTERIA INOCULATION (2012)

This study was conducted to examine the effect of inoculation of plant growth-promotion Rhizobacteria (PGPR) on phenological data, total yield and fruit quality characteristics of strawberry (Fragaria x ananassa Duch) cv. ‘Fern’ during 2006 and 2007. All bacterial root inoculations significantly increased yield per plant (1.98–20.85%), average fruit weight (3.05–19.26%) and first quality fruit ratio (10.30–32.05%) compared to control, whereas the bacterial inoculations did not affect leaf area, first flowering and harvest dates in strawberry cv. ‘Fern’. The bacteria also increased soluble solid content (SSC) and vitamin C in strawberry cv. ‘Fern’. The vitamin C contents of fruits ranged from 47.41 mg 100 g−1 (control) to 53.88 mg 100 g−1 (RC05), while SSC values varied between 10.16% (control) and 12.83% (RC01). Results of this study show that RC19 (Bacillus simplex), RC05 (Paenibacillus polymyxa), and RC23 (Bacillus spp.) have the potential to increase the yield and growth of strawberries.
Alterations in T cell receptor and signal transduction molecules in melanoma patients. (1995)

We have recently described molecular changes in T cells from tumor-bearing patients that are associated with depressed immune function. The present work investigates changes in T-cell signal transduction proteins including the T-cell receptor-zeta (TCR-zeta) chain and receptor-associated tyrosine kinases in patients with metastatic malignant melanoma. A marked decrease in the expression of the TCR-zeta chain was observed in the peripheral blood T cells of 19 (43%) of 44 patients. Decreases in several tyrosine kinases were found in 12 (57%) of 21 patients tested. T cells from patients with diminished TCR-zeta chain expression also showed statistically significant differences in cytokine production pattern, with lower interleukin 2 and IFN-zeta production compared with normal subjects and melanoma patients with normal TCR-zeta chain status. The overall survival of melanoma patients with low TCR-zeta chain expression was significantly shorter than that of patients with normal TCR-zeta chain expression (P = 0.0013). TCR-zeta-deficient patients showed a trend toward having faster growing tumors. There was no correlation between the pretreatment TCR-zeta chain status and albumin or performance status. These findings suggest that alterations in T-cell function occur commonly in melanoma patients and may be independent predictors of clinical outcome.
Autologous Nonfrozen Bone Marrow Transplantation after Intensive Chemotherapy: A Pilot Study (1981)

15 patients with metastatic, nonhematopoietic neoplasms refractory to conventional means of treatment were given intensive chemotherapy followed by infusion of autologous noncryopreserved bone marrow which had been stored at 10 degrees C. This study has shown that the procurement of bone marrow from patients with advanced disease and reinfusion 12 h after high dose chemotherapy is tolerated without significant patient morbidity. The use of marrow stored at 10 degrees C leads to adequate recovery of granulocyte stem cells. The present data also suggest that autologous bone marrow transplantation is beneficial in shortening hematopoietic recovery time in patients receiving high dose chemotherapy and may improve response rates in patients with refractory neoplasms.
Neurological Examination (1977)

* Assistant Professor of Physiological Nursing, University of Washington, Seattle, Washington. † Instructor, Inservice Education and formerly Nursing Coordinator, Neurology-Neurosurgery, University Hospital, University of Washington, Seattle, Washington.
A cochlear prosthesis stimulation algorithm targeting to minimize the rehabilitation phase and enhance speech comprehension (2002)

Efficiency of cochlear stimulation is closely related to the signal processing of the input speech. A variety of techniques were proposed and used for cochlear prosthesis speech analysers. So different seems to be, these techniques are based on two major approaches. The first one consists of stimulating the cochlea according to extracted speech features and the second is based on wide band speech characteristics. Clinically, it is well known that in their initial rehabilitation phase, new cochlear prostheses users face some problems of distinguishing what they hear. This is due to the infinity of stimulation set related to the infinite possibilities of the input speech. In order to overcome this problem and minimise the rehabilitation period, a new stimulation algorithm based upon vector quantization is proposed.
Fault Location for Branched Optical Fiber Networks based on OFDR Technique Using FSF Laser as Light Source (2007)

A new fault location method for passive branched optical fiber networks is proposed, which bases on OFDR technique using FSF laser source, and the fault in fiber branches are located according to the heterodyne detection.
Fast Analytical Design Algorithms for FIR Notch Filters (2004)

Fast analytical design procedures for finite impulse response (FIR) maximally flat (MF) and optimal equiripple (ER) notch filters are introduced. The closed form solution provides recursive computation of the impulse response coefficients of the filter. The ER FIR filters are optimal in the Chebyshev sense. The relation between the MF and ER notch filter is presented in order to emphasize the superior performance of the ER narrow-band filters over their MF counterparts. The discrete nature of the notch frequency in both filter types is emphasized. Four design examples are included to demonstrate the efficiency of the presented approach.
Kerolite-stevensite mixed-layers from the Madrid Basin, Central Spain (1991)

Abstract Structural features of very highly disordered 2:1 trioctahedral phyllosilicates from the Madrid Basin have been studied. Application of Fourier methods to XRD patterns shows that these materials consist of random kerolite-stevensite mixed-layered phases (R = 0) with 50–80% kerolite layers, and have a very small particle size with a mean of three unit-cells stacked in the c * direction. IR spectrum deconvolution in OH-stretching and librational modes seems to indicate five different types of water. Specific surface measurements (N 2 , BET) indicate anomalous high values (240–320 m 2 /g). These results suggest important catalytic and surface chemistry applications.
The structuring of systems using upcalls (1985)

article The structuring of systems using upcalls Share on Author: David D. Clark Laboratory for Computer Science, Massachusetts Institute of Technology, Cambridge, MA Laboratory for Computer Science, Massachusetts Institute of Technology, Cambridge, MAView Profile Authors Info & Claims ACM SIGOPS Operating Systems ReviewVolume 19Issue 5Dec. 1-4, 1985 pp 171–180https://doi.org/10.1145/323627.323645Online:01 December 1985Publication History 224citation2,398DownloadsMetricsTotal Citations224Total Downloads2,398Last 12 Months67Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Robotic Pick-and-Place of Novel Objects in Clutter with Multi-Affordance Grasping and Cross-Domain Image Matching (2018)

This paper presents a robotic pick-and-place system that is capable of grasping and recognizing both known and novel objects in cluttered environments. The key new feature of the system is that it handles a wide range of object categories without needing any task-specific training data for novel objects. To achieve this, it first uses a category-agnostic affordance prediction algorithm to select and execute among four different grasping primitive behaviors. It then recognizes picked objects with a cross-domain image classification framework that matches observed images to product images. Since product images are readily available for a wide range of objects (e.g., from the web), the system works out-of-the-box for novel objects without requiring any additional training data. Exhaustive experimental results demonstrate that our multi-affordance grasping achieves high success rates for a wide variety of objects in clutter, and our recognition algorithm achieves high accuracy for both known and novel grasped objects. The approach was part of the MIT-Princeton Team system that took 1st place in the stowing task at the 2017 Amazon Robotics Challenge. All code, datasets, and pre-trained models are available online at http://arc.cs.princeton.edu.
SnapMe if you can (2013)

The amount of media uploaded to the Web is still rapidly expanding. The ease-of-use of modern smartphones in combination with the proliferation of high-speed mobile networks facilitates a culture of spontaneous and often carefree sharing of user-generated content, especially photos and videos. An increasing number of modern devices are capable of embedding location information and other metadata into created content. However, currently there is not much user awareness of possible privacy consequences of such data. While in most cases users upload their own media consciously, the flood of media uploaded by others is so huge that it is almost impossible for users to stay aware of all media that might be relevant to them. Current social network services and photo-sharing sites mainly focus on the privacy of users' own media in terms of access control, but offer few possibilities to deal with privacy implications created by other users' actions. We conducted an online survey with 414 participants. The results show that users would like to get more information about media shared by others. Based on an analysis of prevalent sharing services like Flickr, Facebook, or Google+ and an analysis of metadata of three different sets of crawled photos, we discuss privacy implications and potentials of the emerging trend of (geo-)tagged media. Finally, we present a novel concept on how location information can actually help users to control the flood of potentially infringing or interesting media.
C-Reactive Protein Inhibits Endothelium-Dependent Nitric Oxide-Mediated Dilation of Retinal Arterioles via Enhanced Superoxide Production (2008)

CRP inhibits endothelium-dependent NO-mediated dilation in retinal arterioles by producing superoxide from NAD(P)H oxidase, which appears to be linked with p38 kinase and RhoA/Rho-kinase activation. By impairing endothelium-dependent NO-mediated vasoreactivity, CRP can potentially facilitate the development of retinal vascular diseases. In addition, statins are beneficial by preserving endothelial function, possibly through inactivation of the RhoA/Rho-kinase pathway.
A Highly Durable RNAi Therapeutic Inhibitor of PCSK9 (2016)

In this phase 1 trial, no serious adverse events were observed with inclisiran. Doses of 300 mg or more (in single or multiple doses) significantly reduced levels of PCSK9 and LDL cholesterol for at least 6 months. (Funded by Alnylam Pharmaceuticals and the Medicines Company; ClinicalTrials.gov number, NCT02314442 .).
The effect on syringe performance of fluid storage and repeated use: implications for syringe pumps. (1996)

Syringe stiction has been reported to cause syringe pump malfunction, hence the effect on syringe performance of syringe use and the formulations used in the syringe were investigated. The force required for syringe plunger motion (at 2.5 mm min-1), when filled with soybean oil emulsion (SBOE) and with water, and the extraction of silicone oil from syringes by these fluids, were measured for Primo, Talus and Terumo 10 mL, and Terumo 50 mL syringes. The breakloose, average extrusion and maximum force required to maintain plunger motion increased after storage of SBOE for 7 days in all syringes tested (p < 0.05). The storage of water increased the breakloose force of all syringes, but only increased the maximum force of Talus syringes, and both the average extrusion and maximum forces of Terumo 10 mL syringes. The mechanism for this is most likely swelling of the elastomer of the piston due to sorption of fluid. The force was found to increase logarithmically with repeated syringe use. Electrothermal atomization atomic absorption spectroscopy was used to measure the silicone oil content of syringe extractions. Three extractions were performed: repeated flushing, vigorous washing, and storage for 7 days with occasional agitation. Up to 69.4% of the silicone oil present in the syringes was extracted with both water and SBOE when they were stored or washed. In contrast to water, SBOE also extracted the lubricant when the syringe was filled and flushed immediately. If syringes are refilled, stored filled before use, or used over a prolonged period, particularly with a SBOE formulation, syringe striction may occur during infusion with a syringe pump.
Implications of Positive Feedback in the Control of Movement (1997)

In this paper we review some theoretical aspects of positive feedback in the control of movement. The focus is mainly on new theories regarding the reflexive role of sensory signals from mammalian tendon organ afferents. In static postures these afferents generally mediate negative force feedback. But in locomotion there is evidence of a switch to positive force feedback action. Positive feedback is often associated with instability and oscillation, neither of which occur in normal locomotion. We address this paradox with the use of analytic models of the neuromuscular control system. It is shown that positive force feedback contributes to load compensation and is surprisingly stable because the length-tension properties of mammalian muscle provide automatic gain control. This mechanism can stabilize control even when positive feedback is very strong. The models also show how positive force feedback is stabilized by concomitant negative displacement feedback and, unexpectedly, by delays in the positive feedback pathway. Other examples of positive feedback in animal motor control systems are discussed, including the beta-fusimotor system, which mediates positive feedback of displacement. In general it is seen that positive feedback reduces the sensitivity of the controlled extremities to perturbations of posture and load. We conclude that positive force feedback can provide stable and effective load compensation that complements the action of negative displacement and velocity feedback.