gebhart/patrepeval huggingface dataset:
Sulfurospirillum arcachonense sp. nov., a New Microaerophilic Sulfur-Reducing Bacterium (1997)

The isolation of a new motile, gram-negative, heterotrophic, sulfur-reducing, microaerophilic, vibrioid bacterium, strain F1F6, from oxidized marine surface sediment (Arcachon Bay, French Atlantic coast) is described. Hydrogen (with acetate as the carbon source), formate (with acetate as the carbon source), pyruvate, lactate, alpha-ketoglutarate, glutarate, glutamate, and yeast extract supported growth with elemental sulfur under anaerobic conditions. Apart from H2 and formate, the oxidation of the substrates was incomplete. Microaerophilic growth was supported with hydrogen (acetate as the carbon source), formate (acetate as the carbon source), acetate, propionate, pyruvate, lactate, alpha-ketoglutarate, glutamate, yeast extract, fumarate, succinate, malate, citrate, and alanine. The isolate grew fermentatively with fumarate, succinate being the only organic product. Elemental sulfur and oxygen were the only electron acceptors used. Vitamins or amino acids were not required. The isolate was oxidase, catalase, and urease positive. Comparative 16S rDNA sequence analysis revealed a tight cluster consisting of the validly described species Sulfurospirillum deleyianum and the strains SES-3 and CCUG 13942 as the closest relatives of strain F1F6 (level of sequence similarity, 91.7 to 92.4%). Together with strain F1F6, these organisms form a novel lineage within the epsilon subclass of proteobacteria clearly separated from the described species of the genera Arcobacter, Campylobacter, Wolinella, and Helicobacter. Due to the phenotypic characteristics shared by strain F1F6 and S. deleyianum and considering their phylogenetic relationship, we propose the inclusion of strain F1F6 in the genus Sulfurospirillum, namely, as S. arcachonense sp. nov. Based on the results of this study, an emended description of the genus Sulfurospirillum is given.
Complete-angle projection diffuse optical tomography by use of early photons (2005)

We present the first, to our knowledge, experimental images of complex-shaped phantoms embedded in diffuse media by use of optical tomography. Imaging is based on a complete-angle projection tomographic technique that utilizes transmitted early photons. Results are contrasted with measurements obtained at later gates as well as pseudocontinuous-wave data. The scanning system developed employs noncontact illumination and detection technologies that allow for high spatial sampling of transmitted photons. Combining this system with complete-angle illumination is found to be an important strategy toward improved imaging performance, resulting in a better-posed inversion problem. The appropriateness of reconstruction algorithms similar to those employed in x-ray computed tomography are showcased, and suggestions for model improvements are provided.
Protein kinase C activation and its role in kidney disease (Review Article) (2006)

Protein kinase C (PKC) comprises a superfamily of isoenzymes, many of which are activated by cofactors such as diacylglycerol and phosphatidylserine. In order to be capable of activation, PKC must first undergo a series of phosphorylations. In turn, activated PKC phosphorylates a wide variety of intracellular target proteins and has multiple functions in signal transduced cellular regulation. A role for PKC activation had been noted in several renal diseases, but two that have had most investigation are diabetic nephropathy and kidney cancer. In diabetic nephropathy, an elevation in diacylglycerol and/or other cofactor stimulants leads to an increase in activity of certain PKC isoforms, changes that are linked to the development of dysfunctional vasculature. The ability of isoform-specific PKC inhibitors to antagonize diabetes-induced vascular disease is a new avenue for treatment of this disorder. In the development and progressive invasiveness of kidney cancer, increased activity of several specific isoforms of PKC has been noted. It is thought that this may promote the kidney cancer's inherent resistance to apoptosis, in natural regression or after treatments, or it may promote the invasiveness of renal cancers via cellular differentiation pathways. In general, however, a more complete understanding of the functions of individual PKC isoforms in the kidney, and development or recognition of specific inhibitors or promoters of their activation, will be necessary to apply this knowledge for treatment of cellular dysregulation in renal disease.
Medical Findings in Outpatients With Anorexia Nervosa (2005)

These results demonstrate a high prevalence of medical findings in community-dwelling women with anorexia nervosa. Therefore, women with anorexia nervosa should be carefully followed up with regular physical examinations and laboratory assessments. In addition, low weight, particularly in conjunction with the abnormalities reported, should prompt the consideration of a diagnosis of anorexia nervosa.
High transparency resists for 157 nm lithography (2003)

157 nm lithography resist based on monocyclic fluorinated polymer with a blocking group of cyclohexylcyclohexanoxymethyl (CCOM) was developed. The transmittance was more than 70% at the resist thickness of 200 nm that corresponds to the absorption coefficient of 0.80 μm−1 at a 157 nm exposure wavelength. The dry-etching rate was improved 1.75 times that of the KrF resist based on polyhydroxystyrene under the conditions of fluorocarbon-based plasma oxide etching. Furthermore, this resist has higher dissolution rate contrast compared with the polymers with the other blocking groups that we evaluated. The resolution limit of 55 nm lines and spaces pattern was obtained using a 150 nm resist thickness. We found that this monocyclic fluorinated polymer with a blocking group of CCOM simultaneously enabled higher transparency, higher dry-etching resistance, and superior imaging performance.
Design of Wireless Sensor Network in SCADA system for wind power plant (2008)

Wireless Sensor Networks (WSNs) is a novel technology, which is developed with the advancement of micro-electronic, computing, and wireless communication technology. WSNs has merits of distributed information processing, covering broadly, and remote monitoring and control. Considering the disperse deployment, wind power resource random and seasonal characteristic in wind plant, we apply WSNs to SCADA system for wind power plant in this paper, which conquers the lack of disperse distribution, difficulty of remote monitoring in wind plant. Considering node cost, resource demand and communication reliability, the hardware of sensor node and sink node are based on 80C51 and ARM chips respectively, and μC/OS-II is selected as the ARM chip operating system. IDD-PC is adopted as routing scheme in wireless data transmission among nodes, which can balance node energy consumption, and be propitious to stability of the network structure. As to the energy limitation of WSN, the method of automatic compensating energy by wind generator is provided.
Registration techniques for image subtraction (2003)

Image subtraction can be used to aid in detection of flaws in a manufactured product by subtracting the image of a perfect product from that of the sample under tests. For this technique to be successful, the two images must be precisely registered. Several registration techniques were applied to various images which had been subjected to translation, rotation, and distortion. It was found that a measure of the amount of translational misregistration could be determined to subpixel accuracy by measurement of binary or gray-scale centroids. Of three techniques for determining rotational misregistration, the measurement of the angle of the binary major axis was the most reliable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Biochemical Efficacy and Safety of Monthly Augmentation Therapy for α1-Antitrypsin Deficiency (1988)

The hereditary disorder alpha 1-antitrypsin (alpha 1AT) deficiency results in the development of emphysema due to a diminished anti-neutrophil elastase screen of the lower respiratory tract. Specific therapy for this disorder is available in the form of weekly intravenous infusions of human plasma alpha 1AT, which effectively reconstitute the anti-elastase screen of the lung in these individuals. In an attempt to reduce the frequency of therapy we evaluated the ability of monthly infusions of alpha 1AT to provide equivalent lower respiratory tract protection against neutrophil elastase. Intravenous infusion of 250 mg/kg of alpha 1AT at 28-day intervals to nine individuals with alpha 1AT deficiency and emphysema was carried out for 12 months. Serum alpha 1AT levels exceeded the protective threshold for an average of 25 days after each dose of alpha 1AT was administered. Furthermore, the postinfusion level of alpha 1AT in the nadir lung epithelial lining fluid was fivefold greater than the preinfusion level, and the anti-neutrophil elastase capacity of the nadir epithelial lining fluid also was elevated significantly, nearly threefold above the preinfusion level. These results indicate that monthly administration of human alpha 1AT is fully capable of adequately augmenting serum and lung alpha 1AT levels and anti-elastase capacity and is therefore a rational alternative to weekly therapy.
Characterization of in vivo tumorigenicity tests using severe immunodeficient NOD/Shi-scid IL2Rγnull mice for detection of tumorigenic cellular impurities in human cell-processed therapeutic products (2015)

The contamination of human cell-processed therapeutic products (hCTPs) with tumorigenic cells is one of the major concerns in the manufacturing and quality control of hCTPs. However, no quantitative method for detecting the tumorigenic cellular impurities is currently standardized. NOD/Shi-scid IL2Rγ<sup>null</sup> (NOG) mice have shown high xeno-engraftment potential compared with other well-known immunodeficient strains, e.g. nude mice. Hypothesizing that tumorigenicity test using NOG mice could be a sensitive and quantitative method to detect a small amount of tumorigenic cells in hCTPs, we examined tumor formation after subcutaneous transplantation of HeLa cells, as a model of tumorigenic cells, in NOG mice and nude mice. Sixteen weeks after inoculation, the 50% tumor-producing dose (TPD<sub>50</sub>) values of HeLa cells were stable at 1.3 × 10<sup>4</sup> and 4.0 × 10<sup>5</sup> cells in NOG and nude mice, respectively, indicating a 30-fold higher sensitivity of NOG mice compared to that of nude mice. Transplanting HeLa cells embedded with Matrigel in NOG mice further decreased the TPD<sub>50</sub> value to 7.9 × 10 cells, leading to a 5000-fold higher sensitivity, compared with that of nude mice. Additionally, when HeLa cells were mixed with 10<sup>6</sup> or 10<sup>7</sup> human mesenchymal stem cells as well as Matrigel, the TPD<sub>50</sub> values in NOG mice were comparable to those of HeLa cells alone with Matrigel. These results suggest that the <i>in vivo</i> tumorigenicity test using NOG mice with Matrigel is a highly sensitive and quantitative method to detect a trace amount of tumorigenic cellular impurities in human somatic cells, which can be useful in the quality assessment of hCTPs.
Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE). (1986)

We have evaluated the subunit composition of plasma von Willebrand factor (vWF) and found evidence that cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease (vWD), but decreased or absent in variants with aberrant structure of individual oligomers. vWF was rapidly purified from plasma on an analytical scale by monoclonal antibody immunoaffinity chromatography in the presence of protease inhibitors. After reduction and electrophoresis in 5% polyacrylamide gels containing sodium dodecyl sulfate, fragments of 189, 176, and 140 kD, as well as the predominant 225-kD subunit, were identified in plasma vWF from 25 normal individuals. The vWF polypeptides were detected by immunoblotting with a mixture of 55 anti-vWF monoclonal antibodies followed by 125I-rabbit anti-mouse antibody and autoradiography. In five individuals with type IIA and five individuals with type IIB vWD, the proportions of 176 and 140-kD fragments were increased relative to the intact 225-kD subunit, as determined by excising each band and quantitating incorporated radioactivity. In contrast, these fragments were either not detectable or were present in only trace amounts in variants with abnormal structure of individual oligomers (types IIC and IID, and a new variant, type IIE vWD). The results reported here provide evidence that absence of large vWF multimers in these two groups of variants results from different mechanisms. In addition, they demonstrate that partial cleavage of the plasma vWF subunit is a normal event.
Companding Transform for Reduction in Peak-to-Average Power Ratio of OFDM Signals (2004)

A general companding transform method is proposed to effectively reduce peak-to-average power ratio (PAPR) of orthogonal frequency division multiplexing (OFDM) signals. By compressing large signals while enhancing small signals along with taking into account their statistical characteristics, this method can achieve significant reduction in PAPR with low implementation complexity. Specifically, we present the design criteria of the transform, which enable effective tradeoff between reduction in PAPR and bit-error rate performance of the OFDM system. It is shown by simulations that the proposed method may significantly improve the performance of OFDM systems in radio channels by carefully choosing the companding form and parameters.
Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas (1993)

Calmodulin-dependent protein kinase III (CaM kinase III) phosphorylates and thereby inactivates eukaryotic elongation factor-2 (EF-2). This enzyme, purified to homogeneity from either rabbit reticulocytes or rat pancreas, had similar properties: it migrated with an apparent M(r) of 140,000 by gel filtration, was comprised of a major polypeptide of M(r) 95,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and had a high affinity for CaM (half-maximal activation < 1 nM). The M(r) 95,000 polypeptide was autophosphorylated by an intramolecular mechanism on seryl residues in the presence of Ca2+, CaM, and ATP, and phosphopeptide mapping indicated that several sites were phosphorylated. Autophosphorylation of CaM kinase III resulted in the generation of a partially Ca2+/calmodulin-independent activity. The enzyme could also be phosphorylated by the catalytic subunit of cAMP-dependent protein kinase. Amino acid sequencing of CaM kinase III indicated that it is distinct from other known proteins including the heat-shock protein hsp90, which was recently suggested to be identical to CaM kinase III (Nygärd, O., Nilsson, A., Carlberg, U., Nilsson, L., and Amons, R. (1991) J. Biol. Chem. 266, 16425-16430). Furthermore, hsp90 did not copurify with CaM kinase III, and the M(r) 95,000 protein did not cross-react with antibodies to hsp90. CaM kinase III exhibited Michaelis-Menten kinetics toward its substrates ATP and EF-2, with Km values of 15 and 2 microM, respectively. CaM kinase III was able to phosphorylate yeast EF-2 with an Km of 2 microM, but the enzyme did not significantly phosphorylate a variety of other substrates, confirming its identification as a novel protein kinase.
Transplantation of Gunn Rats with Autologous Fibroblasts Expressing Bilirubin UDP-Glucuronosyltransferase: Correction of Genetic Deficiency and Tumor Formation (1997)

The end product of the breakdown of the heme group of hemoglobin and other heme-containing proteins is bilirubin. Bilirubin is hydrophobic and cannot be excreted as such. Therefore, mammals have a liver enzyme bilirubin UDP-glucuronosyltransferase (B-UGT), which conjugates bilirubin with glucuronic acid, thereby making the molecule much more water soluble. Bilirubin glucuronides are secreted into bile. Patients with Crigler-Najjar (CN) disease have a deficiency in bilirubin UDP-glucuronosyltransferase and accumulate high serum levels of bilirubin. An animal model for CN disease is the Gunn rat. The obvious target for gene therapy for CN disease is the liver, but because liver cells do only divide infrequently, they are difficult to transduce. To investigate whether cells that are easily transduced can be used to develop gene therapy for CN disease, we have transduced Gunn rat fibroblasts with B-UGT, using a recombinant retrovirus. Gunn rat fibroblasts expressing B-UGT were able to glucuronidate bilirubin present in cell culture media. In this study, we describe the intraperitoneal transplantation of Gunn rats with Gunn rat fibroblasts expressing B-UGT. Transplantation of the fibroblasts corrected the genetic deficiency of the Gunn rats, serum bilirubin concentrations of the transplanted Gunn rats were reduced to normal, and bilirubin glucuronides appeared in bile. However, due to the prolonged period of cell culture, the transplanted fibroblasts were transformed, and the experimental animals developed tumors after transplantation.
Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice. (1979)

Mice of the HRS strain, which carry the mutant gene hr, were examined for abnormalities in representation of the three T-cell sets Ly1, Ly23, and Ly123 in the spleen. The salient feature of hr/hr mice, which are immunologically deficient, in comparison with +/hr segregants, was a gross disproportion in numbers of cells belonging to the Ly1 and Ly123 sets, at the age of 3--3.5 mo. At this age, Ly123 cells of hr/hr spleen outnumbered Ly1 cells by 2:1, whereas in +/hr spleens Ly123 cells were outnumbered by approximately 1:2. Cells from pooled lymph nodes of hr/hr mice did not show a correspondingly gross disporprotion of Ly1 and Ly123 cells. Total counts of splenic T cells, and of B cells, were not significantly different in hr/hr and +/hr mice.
6-Diazo-5-oxo-L-norleucine, A New Tumor-inhibitory Substance. II.<sup>1</sup> Isolation and Characterization<sup>2</sup> (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT6-Diazo-5-oxo-L-norleucine, A New Tumor-inhibitory Substance. II.1 Isolation and Characterization2Henry W. Dion, Salvatore A. Fusari, Zbigniew L. Jakubowski, John G. Zora, and Quentin R. BartzCite this: J. Am. Chem. Soc. 1956, 78, 13, 3075–3077Publication Date (Print):July 1, 1956Publication History Published online1 May 2002Published inissue 1 July 1956https://doi.org/10.1021/ja01594a036RIGHTS & PERMISSIONSArticle Views481Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (357 KB) Get e-Alerts Get e-Alerts
A Scheduling Scheme in a Container-Based Edge Computing Environment Using Deep Reinforcement Learning Approach (2021)

Edge computing has been proposed as an extension of cloud computing to provide computation, storage, and network services in network edge. The tasks requested from terminal devices can be processed at the edge to save network bandwidth and reduce response time as long as the edge server is configured with the corresponding virtualization services. However, the limited capacity of various resources of edge servers and the low-delay service demands of tasks limit the application of traditional virtualization technologies in the task scheduling and resource management of edge computing. Meanwhile, the tasks have become more diverse, which are often divided into independent tasks and complex tasks composed of multiple dependent tasks.In this paper, we study the task scheduling problem in the container-based edge computing environment. Based on the Proximal Policy optimization algorithm, we propose two Task Scheduling algorithms for independent (PPOTS) and dependent (PPODTS). Our objective is to minimize the utility which is a trade-off between the completion time and the energy consumption. Experimental results show that our proposed PPOTS and PPODTS algorithms can reduce the average utility by at least 15.83% (and up to 77.9%) and at least 3.5% (and up to 10.3%) compared with baselines respectively.
Cerebral Death-Like Conditions after Aortic Aneurysm Surgery Using Retrograde Cerebral Perfusion (1993)

A patient with Stanford type A acute aortic dissection who developed severe cerebral dysfunction after surgery using retrograde cerebral perfusion through the superior vena cava was examined. The patient was able to regain normal brain function with no neurological deficit. Postoperative venography taken through the superior vena cava showed the presence of competent venous valves at the venous angles. This suggests that the valves interrupted cerebral perfusion, decreasing blood flow to less than that required. After consideration of the possible causes of brain damage incurred during surgery for aortic aneurysm using retrograde cerebral perfusion, it was concluded that this patient was able to recover normal brain function because the surgery was performed under profound hypothermia.
Chitin biosynthesis inhibition and fungicidal effect of thiosemicarbazones of 2‐formyl‐ and 2‐acetylpyridine, their hydrogenated derivatives and copper complexes thereof (1990)

Abstract Several thiosemicarbazones of 2‐formyl‐ and 2‐acetylpyridine dialkylated on N 4 and non‐alkylated on N 2 were found to be broad‐spectrum protectant fungicides with activity particularly against oomycetes. The effect of some of the compounds on chitin biosynthesis was studied, but the low inhibitory activity observed combined with the fungicidal activity spectrum—particularly the high activity against oomycetes—excludes this as their main mode of action. Attempts at enhancing the systemic properties of the compounds by chemical modifications failed.
Broadband sleeve monopole with very small ground impedance matching network and resistive load (2012)

A broadband sleeve antenna with very small ground has been presented based on impedance matching network and resistive load. The VSWR of the proposed antenna is less than 2 from 0.17GHz to 0.52GHz. The efficiency of the antenna is respectively 23.85% at 0.2GHz and 50.69% at 0.4GHz.