gebhart/patrepeval huggingface dataset:
도재 소성과정이 Ni-Cr 금속도재관의 변연 및 내면 적합도에미치는 영향 (2014)

The purpose of this study in vitro investigation was to compare the marginal and internal fit of Ni-Cr alloy metal ceramic crown before and after porcelain veneering. Furthermore, this study evaluated whether the influence of the porcelain firing on the precision of fit of dental prostheses. The maxillary right incisor was selected as an abutment for experiments. Ten working models were prepared. Ni-Cr alloy cores appropriate for each abutment were prepared by lost wax technique. The marginal area and four internal areas of the crowns were measured at two stages: before veneering process and after upper porcelain firing. Silicone replica techniques were used. The data were statistically analyzed with the paired t-test(α=0.05). Mean±SD marginal and internal gap were 67.1±23.3 μm for the nickle chrome alloy core group and 74.4±21.9 μm for the metalceramic crown group. There were statistically significant differences in all investigated areas (p＜0.05). Within the limitations of this study, none of the Ni-Cr alloy metal crown values measured after porcelain firing process exceeded 120 μm, which is the clinically acceptable threshold.
An epigenetic chromatin remodeling role for NFATc1 in transcriptional regulation of growth and survival genes in diffuse large B-cell lymphomas (2010)

The nuclear factor of activated T cells (NFAT) family of transcription factors functions as integrators of multiple signaling pathways by binding to chromatin in combination with other transcription factors and coactivators to regulate genes central for cell growth and survival in hematopoietic cells. Recent experimental evidence has implicated the calcineurin/NFAT signaling pathway in the pathogenesis of various malignancies, including diffuse large B-cell lymphoma (DLBCL). However, the molecular mechanism(s) underlying NFATc1 regulation of genes controlling lymphoma cell growth and survival is still unclear. In this study, we demonstrate that the transcription factor NFATc1 regulates gene expression in DLBCL cells through a chromatin remodeling mechanism that involves recruitment of the SWItch/Sucrose NonFermentable chromatin remodeling complex ATPase enzyme SMARCA4 (also known as Brahma-related gene 1) to NFATc1 targeted gene promoters. The NFATc1/Brahma-related gene 1 complex induces promoter DNase I hypersensitive sites and recruits other transcription factors to the active chromatin site to regulate gene transcription. Targeting NFATc1 with specific small hairpin RNA inhibits DNase I hypersensitive site formation and down-regulates target gene expression. Our data support a novel epigenetic control mechanism for the transcriptional regulation of growth and survival genes by NFATc1 in the pathophysiology of DLBCL and suggests that targeting NFATc1 could potentially have therapeutic value.
Glycans in Sera of Amyotrophic Lateral Sclerosis Patients and Their Role in Killing Neuronal Cells (2012)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by degeneration of upper and lower motor neurons. To date, glycosylation patterns of glycoproteins in fluids of ALS patients have not been described. Moreover, the aberrant glycosylation related to the pathogenesis of other neurodegenerative diseases encouraged us to explore the glycome of ALS patient sera. We found high levels of sialylated glycans and low levels of core fucosylated glycans in serum-derived N-glycans of patients with ALS, compared to healthy volunteer sera. Based on these results, we analyzed the IgG Fc N(297)-glycans, as IgG are major serum glycoproteins affected by sialylation or core fucosylation and are found in the motor cortex of ALS patients. The analyses revealed a distinct glycan, A2BG2, in IgG derived from ALS patient sera (ALS-IgG). This glycan increases the affinity of IgG to CD16 on effector cells, consequently enhancing Antibody-Dependent Cellular Cytotoxicity (ADCC). Therefore, we explore whether the Fc-N(297)-glycans of IgG may be involved in ALS disease. Immunostaining of brain and spinal cord tissues revealed over-expression of CD16 and co-localization of intact ALS-IgG with CD16 and in brain with activated microglia of G93A-SOD1 mice. Intact ALS-IgG enhanced effector cell activation and ADCC reaction in comparison to sugar-depleted or control IgG. ALS-IgG were localized in the synapse between brain microglia and neurons of G93A-SOD1 mice, manifesting a promising in vivo ADCC reaction. Therefore, glycans of ALS-IgG may serve as a biomarker for the disease and may be involved in neuronal damage.
Magnetic Particles as Liquid Carriers in the Microfluidic Lab-in-Tube Approach To Detect Phase Change (2014)

Magnetic beads (MBs) with ∼1.9 μm average diameter were used to transport specific microliter-scale volumes of liquids between adjacent reservoirs within a closed tube under the influence of a magnetic field. The tube's inner surface is coated with a hydrophobic layer, enabling the formation of a surface tension valve by inserting an air gap between reservoirs. This transfer process was implemented by keeping the MBs stationary with a fixed external magnet while the liquid reservoirs were translated by a computer-controlled syringe pump system. The magnet induces the aggregation of MBs in a loosely packed cluster (void volume ∼90-95%) against the tube's inner wall. The liquid trapped in the MB cluster is transported across the air gap between reservoirs. Fluorescence intensity from a dye placed in one reservoir is used to measure the volume of liquid transferred between reservoirs. The carry-over liquid volume is controlled by the mass of the MBs within the device. The typical volume of liquid carried by the MB cluster is ∼2 to 3 μL/mg of beads, allowing the use of small samples. This technique can be used to study the effect of small compositional variation on the properties of fluid mixtures. The feasibility of this "lab-in-tube" approach for binary phase diagram determination in a water-surfactant (C12E5) system was demonstrated.
Remotely Switched OTDR Conformance Testing at the Fiber Distribution Hub (2009)

Conformance testing is a critical step in ensuring the future quality of a passive optical network. A new automated test procedure couples an optical switch and a hand-held test set to enable significant labor savings.
Review: Archeological Excavations at Jamestown Colonial National Historical Park and Jamestown National Historic Site, Virginia by John L. Cotter (1961)

Book Review| October 01 1961 Review: Archeological Excavations at Jamestown Colonial National Historical Park and Jamestown National Historic Site, Virginia by John L. Cotter Archeological Excavations at Jamestown Colonial National Historical Park and Jamestown National Historic Site, VirginiaJohn L. Cotter G. Hubert Smith G. Hubert Smith Search for other works by this author on: This Site PubMed Google Scholar Journal of the Society of Architectural Historians (1961) 20 (3): 148. https://doi.org/10.2307/988098 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation G. Hubert Smith; Review: Archeological Excavations at Jamestown Colonial National Historical Park and Jamestown National Historic Site, Virginia by John L. Cotter. Journal of the Society of Architectural Historians 1 October 1961; 20 (3): 148. doi: https://doi.org/10.2307/988098 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentJournal of the Society of Architectural Historians Search This content is only available via PDF. Copyright 1961 The Society of Architectural Historians Article PDF first page preview Close Modal You do not currently have access to this content.
Distance Learning for Similarity Estimation (2008)

In this paper, we present a general guideline to find a better distance measure for similarity estimation based on statistical analysis of distribution models and distance functions. A new set of distance measures are derived from the harmonic distance, the geometric distance, and their generalized variants according to the Maximum Likelihood theory. These measures can provide a more accurate feature model than the classical Euclidean and Manhattan distances. We also find that the feature elements are often from heterogeneous sources that may have different influence on similarity estimation. Therefore, the assumption of single isotropic distribution model is often inappropriate. To alleviate this problem, we use a boosted distance measure framework that finds multiple distance measures which fit the distribution of selected feature elements best for accurate similarity estimation. The new distance measures for similarity estimation are tested on two applications: stereo matching and motion tracking in video sequences. The performance of boosted distance measure is further evaluated on several benchmark data sets from the UCI repository and two image retrieval applications. In all the experiments, robust results are obtained based on the proposed methods.
Ex-Vivo Expanded Human Bone Marrow-Derived AC133+ Cells To Treat Myocardial Infarction. (2004)

Abstract To examine whether ex-vivo expanded human bone marrow (BM)-derived AC133+ cells may participate in post myocardial infarction (MI) healing, we have examined the effect of the copper chelator tetraethylenepentamine (TEPA) on the ex-vivo expansion potential of BM-derived stem cell populations and the effect of the resulting ex-vivo expanded AC133+ cells in a MI animal model. AC133+ cells isolated from human BM, using the CliniMACS device, at purities greater than 90% were expanded in Teflon bags, in the presence of IL-6, TPO, Flt-3 ligand, and SCF with or without TEPA for three weeks. The progenitor cell composition and potential were examined at the end of the treatment time and after long-term incubation in culture. After 3 weeks in TEPA-treated cultures the total nuclear cell expanded more than 200±20 fold. The increase in the CD34+, AC133+ and AC133+/CD38-cell populations was 17±13, 16±1 and 270±110 - fold, respectively, and the CFU content was 84±28 fold higher than at the initiation of the cultures. Contrary to TEPA treated cultures, the cultures treated in the absence of the chelator lost their progenitor populations by week 5-7 in culture. Ex-vivo expanded AC133+ cells for 3 weeks expressed VEGF and VEGF receptor RNA as examined by RT-PCR. An MI model was established in athymic nude rats by permanent ligation of the left anterior descending coronary artery. Ex-vivo expanded AC133+ cells (6x106 cells/rat) or saline (control) were injected at the scar tissue 6 days post MI. Four weeks after cell therapy, the hearts were harvested and examined. Staining for smooth-muscle alpha-actin detected a 1.6-fold increase in capillary and arteriole density in the expanded cell-treated vs. control hearts. Preliminary echocardiographic studies compared 4 weeks post-treatment with those observed prior to treatment. Expanded BM-derived AC133+ injection into the infarcted myocardium improved left ventricular (LV) remodeling as demonstrated by increasing LV systolic dimensions only by 11%±4 while increasing by 53%±17 in control animals (p=0.02). Similarly, AC133+ cell injection improved LV contractility as demonstrated by increasing fractional shortening (FS) by 58%±44 whereas FS decreased by 20%± 5 in control animals (p=0.14). In addition, AC133+ cell injection prevented scar thinning as demonstrated by a decrease in anterior wall thickness of 10%±4 whereas the decrease in anterior wall thickness was 30%±7.5 in control saline-treated animals (p<0.05). Clinical trials examining the safety and feasibility of intra-corronary injection of ex-vivo expanded autologous BM-derived AC133+ to patients with ischemic heart disease, are currently in preparation. Conclusion: A. TEPA allows BM-derived AC133+ cells to self renew by permitting proliferation ex-vivo while hindering their differentiation. B. Our preliminary results suggest that injection of ex-vivo expanded BM-derived AC133+ cells into infarcted myocardium results in new vessel formation and improves left ventricular function.
Curcumin delays development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors (2010)

We suggest that curcumin be tested as a dietary chemopreventive agent in women already exposed to MPA, in an effort to decrease or delay the risk of breast cancer associated with combined HT.
Prospective Study of Adult Onset Diabetes Mellitus (Type 2) and Risk of Colorectal Cancer in Women (1999)

Our data provide support for the hypothesis that diabetes is associated with an increased risk of colorectal cancer in women.
Surface Organozirconium Electrophiles Activated by Chemisorption on “Super Acidic” Sulfated Zirconia as Hydrogenation and Polymerization Catalysts. A Synthetic, Structural, and Mechanistic Catalytic Study (2002)

Structural studies including 13C CPMAS NMR spectroscopy of the 13Cα-enriched model adsorbates Cp‘2Th(13CH3)2 (1*) and CpTi(13CH3)3 (2*) (Cp = η5-C5H5, Cp‘= η5-(CH3)5C5), and organozirconium adsorbates Cp2Zr(13CH3)2 (3*), Cp‘Zr(13CH3)3 (4*), and Zr(13CH2tBu)4 (6*) chemisorbed on superacidic sulfated zirconia (ZRSx; x = activation temperature) reveal that all adsorbates undergo a new molecular chemisorptive process: protonolytic M−C σ-bond cleavage at the very strong surface Brønsted acid sites to yield “cation-like” organometallic electrophiles. A kinetic and mechanistic study is reported for olefin and arene hydrogenation and α-olefin homopolymerization meditated by the catalysts formed by chemisorption of Cp2Zr(CH3)2 (3), Cp‘Zr(CH3)3 (4), Zr(CH2TMS)4 (5), Zr(CH2tBu)4 (6), and Zr(CH2Ph)4 (7), onto zirconia (ZR) or ZRSx. At 25 °C, 14.7 psi H2, 1-hexene hydrogenation activity follows the order 4/ZRS400 ≫ 3/ZRS400 ≥ 3/ZRS300 ≫ 3/ZRS720 ≫ 3/ZR ∼ 0. Benzene hydrogenation rates (25 °C, 14.7 psi H2) follow the order 4/ZRS400 ≫ 5/ZRS400 > 6/ZRS400 > 7/ZRS400, with Nt = 970 h-1 for 4/ZRS400 making this the most active benzene hydrogenation catalyst yet discovered. As a function of arene substituent(s), 4/ZRS400 exhibits high chemoselectivity, with hydrogenation rates following the order benzene ≫ toluene ≫ p-xylene ∼ 0. For benzene hydrogenation by 6/ZRS400, kinetic data obey the rate law Nt = kobs[arene]0[PH2]1 with Ea = 10.3(8) kcal mol-1. Partially hydrogenated products are not detected at partial conversions, with H2 delivered pairwise to both faces of C6D6, forming all-cis and cis, cis, trans, cis, trans isotopomers (1:3.1). Protonolytic poisoning experiments reveal that a maximum of ∼68% of Zr sites in 4/ZRS400 are catalytically significant for benzene hydrogenation. Relative homopolymerization rates are 7/ZRS400 > 5/ZRS400 > 6/ZRS400 > 4/ZRS400 for both ethylene (150 psi C2H4, 60 °C) and liquid propylene (20 °C).
Correction: Rapid Genome Mapping in Nanochannel Arrays for Highly Complete and Accurate De Novo Sequence Assembly of the Complex Aegilops tauschii Genome (2013)

Next-generation sequencing (NGS) technologies have enabled high-throughput and low-cost generation of sequence data; however, de novo genome assembly remains a great challenge, particularly for large genomes. NGS short reads are often insufficient to create large contigs that span repeat sequences and to facilitate unambiguous assembly. Plant genomes are notorious for containing high quantities of repetitive elements, which combined with huge genome sizes, makes accurate assembly of these large and complex genomes intractable thus far. Using two-color genome mapping of tiling bacterial artificial chromosomes (BAC) clones on nanochannel arrays, we completed high-confidence assembly of a 2.1-Mb, highly repetitive region in the large and complex genome of Aegilops tauschii, the D-genome donor of hexaploid wheat (Triticum aestivum). Genome mapping is based on direct visualization of sequence motifs on single DNA molecules hundreds of kilobases in length. With the genome map as a scaffold, we anchored unplaced sequence contigs, validated the initial draft assembly, and resolved instances of misassembly, some involving contigs ,2 kb long, to dramatically improve the assembly from 75% to 95% complete.
Molecular Beam Epitaxy: Applications to Key Materials (1995)

In this volume, the editor and contributors describe the use of molecular beam epitaxy (MBE) for a range of key materials systems that are of interest for both technological and fundamental reasons. Prior books on MBE have provided an introduction to the basic concepts and techniques of MBE and emphasize growth and characterization of GaAs-based structures. The aim in this book is somewhat different; it is to demonstrate the versatility of the technique by showing how it can be utilized to prepare and explore a range of distinct and diverse materials. For each of these materials systems MBE has played a key role both in their development and application to devices.
[From scientific evidence to operative practice: towards a model of occupational medicine based on on efficacy evidence]. (2002)

There is increasing interest in improving health care practice and in providing evidence-based health care, that is, care in which different stakeholders consistently consider research evidence when making decisions. Quality of health care is presently viewed as a goal towards which different health care settings are geared. In comparison with this approach and in spite of the large development potentialities, occupational health practice is only at the beginning of the process. ILO convention No. 161 already pointed out the need to provide customers with quality-oriented services and evidence-based services. Occupational health practice can be analysed by means of a general system model already established for health care systems including input (structure, management, personnel, equipment), process (activities, performance), output (advice, recommendation), outcome (good life quality, sickness absence, work ability). All these elements can be critically measured with appropriate indicators to evaluate their efficacy. Despite general agreement about the importance of such analysis, there is a lack of data on the efficacy of prevention programmes. According to the evidence-based medicine model, which is commonly used by many other medical specialties, occupational health physicians could adopt a similar approach in order to implement more efficacious interventions. The evidence-based paradigm consists in the conscientious, explicit and judicious use of available best evidence in making decisions about health care problems. The practice of evidence-based medicine means integrating individual expertise with the best current evidence from systematic research. Evidence-based occupational health should implement this innovative approach to evaluate and to improve the efficiency of prevention services by means of the ability to (i) formulate the questions on the problem; (ii) search for scientific evidence; (iii) critically evaluate scientific evidence; (iv) use evidence as a key element for the decision process.
Effects of Nitrate, Nitrite and Diphenylamine on the Photosynthetic Apparatus of Rhodopseudomonas sphaeroides f. sp. denitrificans (1985)

Summary: We have compared the effect of diphenylamine (DPA) on the pigment composition of Rhodopseudomonas sphaeroides f. sp. denitrificans grown in photoheterotrophic culture with the previously reported effect of nitrate. It was demonstrated that the effect of nitrate is due to the nitrite which is produced during denitrification. Both nitrite and DPA caused a decrease in the synthesis of spheroidene, and the accumulation of more-reduced precursors not normally seen. Nitrate (effectively nitrite) caused a decrease in the amount of bacteriochlorophyll, and the reaction centre from denitrifying cells did not contain the 28 kDal polypeptide (RC-H) subunit. These effects did not occur over a range of DPA additions (4 to 8 μ;g ml−1) to cells growing in the absence of nitrate. Denitrifying cells also had 40-50% lower activity of δ-aminolaevulinic acid synthase than those grown with or without DPA. Both nitrite and DPA treatments resulted in the loss of the B870 light-harvesting complex because of a failure to synthesize its 12 kDal polypeptide subunit.
Acute renal failure due to acetaminophen ingestion (1995)

Acetaminophen is the most commonly reported drug overdose in the United States. Acute renal failure occurs in less than 2% of all acetaminophen poisonings and 10% of severely poisoned patients. At the therapeutic dosages, acetaminophen can be toxic to the kidneys in patients who are glutathione depleted (chronic alcohol ingestion, starvation, or fasting) or who take drugs that stimulate the P-450 microsomal oxidase enzymes (anticonvulsants). Acute renal failure due to acetaminophen manifests as acute tubular necrosis (ATN). ATN can occur alone or in combination with hepatic necrosis. The azotemia of acetaminophen toxicity is typically reversible, although it may worsen over 7 to 10 days before the recovery of renal function occurs. In severe overdoses, renal failure coincides with hepatic encephalopathy and dialysis may be required. Recognition of acetaminophen nephropathy requires the following: (1) a thorough drug history, including over-the-counter medications such as Tylenol or Nyquil; (2) knowledge of the risk factors that lessen its margin of safety at therapeutic ingestions, i.e., alcoholism; and (3) consideration of acetaminophen in the differential diagnosis of patients who present with combined hepatic dysfunction and ATN.
Rhinovirus neutralizing antibody in tears, parotid saliva, nasal secretions and serum. (1967)

Summary Virus neutralization studies were performed on tears, parotid secretions, nasal secretions, and serum obtained from 13 volunteers infected with rhinovirus 15. Neutralizing activity appeared in tears from 9 volunteers, in parotid saliva from 8 volunteers, in nasal secretions from 10 volunteers, and in serum from 13 volunteers. Studies with four volunteers revealed that neutralizing activity was detected first in serum; then and simultaneously in tears, parotid saliva and nasal secretions. Sucrose density gradient ultracentrifugation studies of specimens from two volunteers revealed that the predominant immunoglobulin in all three secretions was IgA and that in each secretion this immunoglobulin was associated with neutralizing activity. Although rhinovirus 15 was repeatedly recovered from nasal secretion specimens from each volunteer, none of the tear or parotid saliva specimens contained virus. Studies with an additional eight volunteers demonstrated that rhinovirus 15 could not be recovered from blood specimens obtained during incubation period, maximum virus shedding from the nasopharynx, or recovery.