gebhart/patrepeval huggingface dataset:
Twist-Defect-Mode Lasing in Photopolymerized Cholesteric Liquid Crystal (2003)

The twist defect mode (TDM) has been experimentally demonstrated in the transmission spectrum of a composite film consisting of two photopolymerized cholesteric liquid crystal (PCLC) layers. The self-organized helical structure of PCLC acts as a one-dimensional (1-D) photonic crystal, and the twist defect which is a discontinuity of the director rotation around the helix axis at an interface of two PCLC layers, induces the TDM. Optically pumped laser action based on the TDM has also been observed in a dye-doped double composite PCLC film. At a high excitation energy above the threshold, the laser action has been observed at the TDM wavelength in the middle of the 1-D photonic band gap of the PCLC helical structure.
G115 Study on Utilization of Solar Thermal Energy by Inverted Brayton Cycle (2001)

This paper presents a study of the performance of the solar thermal power generation system that has been working on the Inverted Brayton cycle. The temperature rise of the HTS (Heat Transfer Salt) is measured by experimentally. The HTS used as heat storage material in heated by focusing and solar energy through the convex lens. The heat storage and heat transport characteristics are investigated by using the experimental model heated by electric heater. It is shown that if the high temperature HTS of more than 300 degree centigrade was realized, this solar thermal power generation system has revealed more than 30% of thermal efficiency.
Sarcoidosis and MIF gene polymorphism: a case–control study in an Irish population (2006)

Macrophage migration inhibitory factor is a key pro-inflammatory mediator. A 5-CATT repeat functional polymorphism within the promoter of the gene was previously associated with the lowest promoter activity. It was hypothesised that patients exhibiting a 5-CATT allele would have a less aggressive inflammatory response with an associated less severe clinical phenotype in sarcoidosis. Irish Caucasian sarcoidosis patients (n = 173) followed up for 1-39 yrs and a control group (n = 166) were genotyped for the CATT repeat polymorphism. Disease severity at the time of diagnosis and at the time of elaboration of the present study was assessed by the presence of thoracic and extrathoracic symptoms, erythema nodosum, radiographic interstitial changes (chest radiograph score equal to stage II or greater, or high-resolution computed tomography confirmed), pulmonary function tests, steroid use, erythrocyte sedimentation rate, C-reactive protein and angiotensin-converting enzyme levels. In the Irish population studied, no evidence was found of a significant association between either sarcoidosis susceptibility and disease severity and the 5-CATT repeat functional polymorphism in the macrophage migration inhibitory gene. The present study found no significant association between the 5-CATT repeat macrophage migration inhibitory factor gene polymorphism and sarcoidosis, and did not support the overriding role for macrophage migration inhibitory factor in driving sarcoidosis pathogenesis.
Proline-Directed Protein Kinase FA as a Potential Target for Diagnosis and Therapy of Human Cancers (2004)

Proline-directed protein kinase FA (PDPK FA) was originally identified as a phosphatase activating factor (FA) but has subsequently been characterized as a multisubstrate/multifunctional PDPK possibly associated with human cancers. In recent years, the immunohistochemical study revealed that PDPK FA was highly expressed in tumor mass and preferentially overexpressed in the invasive lesions of the resected tissue sections obtained from various types of cancer patients. The clinicopathologic study further revealed a close correlation of the overexpression of PDPK FA with poor prognosis of the cancer patients. The antisense gene therapy study also confirmed that due to its multisubstrate/multifunctional PDPK nature, the overexpression of PDPK FA is essential for the development of malignant growth, tumorigenesis, invasion, metastasis, anti-differentiation, anti-apoptosis and chemoresistance in human cancers. From immunohistochemical, clinicopathologic and antisense gene therapeutic studies combined together, PDPK FA has emerged as a key regulator of all aspects of neoplasia. In this way, nature provides prima facie evidence of a particular protein kinase's pivotal importance to the neoplastic state. PDPK FA therefore represents a newly-described, previously-undiscovered novel signal transducing target for diagnosis, disease monitoring, drug screening and therapy of human cancers.
Learning of Ontologies from the Web: the Analysis of Existent Approaches. (2001)

The next generation of the Web, called Semantic Web, has to improve the Web with semantic (ontological) page annotations to enable knowledge-level querying and searches. Manual construction of these ontologies will require tremendous efforts that force future integration of machine learning with knowledge acquisition to enable highly automated ontology learning. In the paper we present the state of the-art in the field of ontology learning from the Web to see how it can contribute to the task of semantic Web querying. We consider three components of the query processing system: natural language ontologies, domain ontologies and ontology instances. We discuss the requirements for machine learning algorithms to be applied for the learning of the ontologies of each type from the Web documents, and survey the existent ontology learning and other closely related approaches.
Construction and Performance Characteristics of a Prototype NBS/GPS Receiver (1981)

The construction and performance characteristics of a low-cost, high-accuracy GPS C/A receiver are reviewed. The receiver takes advantage of a simultaneous common view of the same satellites, which could allow time transfer with accuracies on the order of 10 ns or less for baselines as large as 3000 km. Frequency can be measured to better than one part in 10 to the 14th. The software and the receiver are configured to be fully automatic with a Z80A microprocessor setting the amplitude for the lock loops of the receiver and setting the synthesizer with corrects for Doppler shift. The microprocessor can calibrate a 0.1 ns built-in time interval counter.
Independent Prognostic Value of Elevated C-Reactive Protein in Unstable Angina (1999)

In unstable angina, CRP is a strong independent marker of increased 90-day risk. Compared with CRP at admission, CRP at discharge is better related to later outcome and could be of great utility for risk stratification.
Predictive simulation of guide-wave structural health monitoring (2017)

This paper presents an overview of recent developments on predictive simulation of guided wave structural health monitoring (SHM) with piezoelectric wafer active sensor (PWAS) transducers. The predictive simulation methodology is based on the hybrid global local (HGL) concept which allows fast analytical simulation in the undamaged global field and finite element method (FEM) simulation in the local field around and including the damage. The paper reviews the main results obtained in this area by researchers of the Laboratory for Active Materials and Smart Structures (LAMSS) at the University of South Carolina, USA. After thematic introduction and research motivation, the paper covers four main topics: (i) presentation of the HGL analysis; (ii) analytical simulation in 1D and 2D; (iii) scatter field generation; (iv) HGL examples. The paper ends with summary, discussion, and suggestions for future work.
Site-directed mutagenesis of the small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase from Anacystis nidulans (1987)

Using oligonucleotide-directed mutagenesis of the gene encoding the small subunit (rbcS) from Anacystis nidulans mutant enzymes have been generated with either Trp-54 of the small subunit replaced by a Phe residue, or with Trp-57 replaced by a Phe residue, whereas both Trp-54 and Trp-57 have been replaced by Phe residues in a double mutant. Trp-54 and Trp-57 are conserved in all amino acid sequences or the small subunit (S) that are known at present. The wild-type and mutant forms of Rubisco have all been purified to homogeneity. The wild-type enzyme, purified from Escherichia coli is indistinguishable from enzyme similarly purified from A. nidulans in subunit composition, subunit molecular mass and kinetic parameters (Vmax CO2 = 2.9 U/mg, Km CO2 = 155 microM). The single Trp mutants are indistinguishable from the wild-type enzyme by criteria (a) and (b). However, whereas, Km CO2 is also unchanged, Vmax CO2 is 2.5-fold smaller than the value for the wild-type enzyme for both mutants, demonstrating for the first time that single amino acid replacements in the non-catalytic small subunit influence the catalytic rate of the enzyme. The specificity factor tau, which measures the partitioning of the active site between the carboxylase and oxygenase reactions, was found to be invariant. Since tau is not affected by these mutations we conclude that S is an activating not a regulating subunit.
Seven-coordinate complexes of tantalum(I) (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeven-coordinate complexes of tantalum(I)S. Datta and S. S. WrefordCite this: Inorg. Chem. 1977, 16, 5, 1134–1137Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://pubs.acs.org/doi/10.1021/ic50171a031https://doi.org/10.1021/ic50171a031research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improved Ceramic Anodes for Corrosion Protection. (1984)

Ceramic anodes used for cathodic protection are currently made with expensive metals (niobium, tantalum) as substrates, and these anodes have a limited useful life. This study investigated plasma-sprayed ceramic coatings on aluminum and stainless steel substrates, as well as solid sintered ceramics, as less expensive and longer-lived alternatives. Anodes made of stainless steel substrates with an electroplated coating of a 'passive' metal(tantalum) followed by a lithium-ferrite plasma-sprayed coating showed excellent promise. However, a triple layer plasma-sprayed coating system consisting of lithium ferrite over niobium over Ni-Cr-Al-Y sealcoat on 316L stainless steel and aluminum alloy substrates proved unacceptable as a possible anode material because of severe cracking and spalling. Solid sinter Mn and Mn-Zn ferrites also showed potential. They were fabricated with careful control of the postsintering cooling rate to yield materials with anodic dissolution rates less than 0.5 grams per amp year (g/A-yr). This is considerably improved from the 1 to 2 g/A-yr previously reported for plasma-sprayed lithium ferrite on a valve metal substrate. Donor doped and reduced solid sintered titanate compounds yielded electrically conductive materials, but they broke down so quickly and severely under anodic polarization testing that they are not suitable for cathodic protection applications. Originator-supplied keywords include: Anodic coatings.
Photodynamic Therapy for Cholangiocarcinoma (2010)

Cholangiocarcinoma is the primary malignancy arising from the biliary epithelium, and it presents as jaundice, cholestasis, and cholangitis. Over 50 percent of patients present with advanced-stage disease, and the prognosis is poor with the survival measured in months even after biliary decompression. Palliative management has become the standard of care for unresectable disease, and this involves an endoscopic approach. Photodynamic therapy (PDT) involves the administration of a photosensitizer followed by local irradiation with laser therapy. The use of PDT for palliation of bile-duct tumors has produced promising results. Several studies conducted in Europe and the United States have shown that PDT produces a marked improvement in the symptoms of cholestasis, survival, and quality of life. This chapter summarizes the principle of PDT, the technique employed, and the published experience regarding PDT for cholangiocarcinoma.
Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: Results of a forty‐eight–week randomized, double‐blind, placebo‐controlled, parallel‐group phase III trial (2012)

Abstract Objective To evaluate the safety and efficacy of ocrelizumab plus methotrexate (MTX) or leflunomide (LEF) in patients with active rheumatoid arthritis (RA) and an inadequate response to tumor necrosis factor α inhibitors. Methods This was a multicenter randomized, double‐blind, placebo‐controlled, parallel‐group study that continued over 48 weeks. Patients receiving stable doses of MTX or LEF were randomized to receive 2 infusions of placebo (n = 277), ocrelizumab 200 mg (n = 278), or ocrelizumab 500 mg (n = 285) on days 1 and 15 as well as at weeks 24 and 26. Coprimary end points were the proportion of patients with response according to the American College of Rheumatology 20% improvement criteria (ACR20) at weeks 24 and 48. Secondary end points included the change from baseline in the modified Sharp/van der Heijde score (SHS) and the ACR50/70 responses. Results ACR20 responses were 22.0% in the placebo group, 42.2% in the ocrelizumab 200 mg group, and 47.9% in the ocrelizumab 500 mg group at 24 weeks and 19.5%, 48.7%, and 50.7%, respectively, at 48 weeks ( P < 0.0001 versus placebo for each comparison at each time point). At 48 weeks, patients receiving both doses of ocrelizumab showed significantly improved ACR50 and ACR70 responses of ∼3‐fold versus placebo. Only those in the ocrelizumab 500 mg group showed statistically significant ( P = 0.0017) inhibition of joint damage progression (mean change in the SHS) relative to placebo (61% inhibition) at 48 weeks. Overall adverse events and infections during the 48 weeks of study were comparable in all treatment groups. Serious infections were observed more frequently in patients taking ocrelizumab (5.1% and 4.3%) than in those taking placebo (2.5%). Conclusion Patients in both of the ocrelizumab groups met the clinical primary efficacy end points. Inhibition of change in the SHS was statistically significant at 48 weeks for those in the ocrelizumab 500 mg group. The rate of serious infections in this trial was higher for both ocrelizumab doses as compared with placebo.
Tolerability, pharmacokinetics and night‐time effects on postural sway and critical flicker fusion of gaboxadol and zolpidem in elderly subjects (2008)

A bedtime dose of gaboxadol 10 mg was generally well tolerated. Changes in body sway at 1.5 h after bedtime dosing were smaller with gaboxadol 10 mg than with zolpidem 5 mg, whereas changes were similar at 4 h for both treatments and returned to near baseline at 8 h.
SYNTHESIS OF PYRAZOLONES FROM α-KETO AND α-CYANO ESTERS (1952)

1,4-Dimethyl-3-amino-5-pyrazolone and 4-methyl- and 4-ethyl-3-amino-1-phenyl-5-pyrazolones were synthesized from α-keto esters and methyl- and phenylhydrazines. The hydrazones first obtained were transformed into pyrazolones having a carbethoxy group in position 3, which was converted into an amino group by a Curtius degradation. 2,4-Dimethyl-3-amino-5-pyrazolone was obtained directly from methylhydrazine and ethyl α-cyanopropionate. A series of 3-imino-2-methyl-5-pyrazolones monosubstituted in position 4 with pentyl, hexyl, heptyl, and octyl groups and another series disubstituted in position 4 with butyl, hexyl, and heptyl groups were also prepared from the corresponding mono- and disubstituted cyanoacetates and methylhydrazine.The ultraviolet absorption spectra were determined in neutral and acid medium.
Cell-free synthesis and assembly of vesicular stomatitis virus nucleocapsids (1983)

The association of newly synthesized vesicular stomatitis virus proteins into nucleocapsid structures was examined in a cell-free system that supports concurrent viral protein synthesis, transcription, and RNA replication. The vesicular stomatitis virus proteins synthesized by this system associated with the newly replicated RNA to form structures that banded in CsCl gradients with marker nucleocapsids. In reactions lacking nucleocapsid templates to program RNA synthesis, the newly synthesized proteins did not associate into nucleocapsid structures. The newly synthesized proteins associated with nucleocapsids were analyzed by electrophoresis on polyacrylamide gels containing sodium dodecyl sulfate after separation from non-associated proteins by chromatography on Bio-Gel A15M agarose columns. The results of this analysis showed that newly synthesized L, NS, and N proteins associated into nucleocapsids in the in vitro system. In addition, a small amount of newly synthesized M protein was stably bound to the nucleocapsids. The molar ratio of the associated, newly synthesized proteins was 2:350:1,000:10 (L:NS:N:M). More than 90% of the newly synthesized NS protein that associated with nucleocapsids in vitro was of the NS2 subspecies, as assayed by DEAE-cellulose column chromatography. The stability of the association of the newly synthesized proteins with nucleocapsids in the system mimicked that of the association of viral proteins with nucleocapsids from infected cells as measured by salt sensitivity. These data indicate that nucleocapsids were assembled from newly synthesized proteins within our in vitro system and that the molar ratio of assembled proteins was similar to that observed for virion nucleocapsids.
Persistent adhesion of corneal epithelial tissue on synthetic lenticules <i>in vivo</i> (1998)

The formation of these adhesive structures is likely to have contributed to the sustained epithelialization observed clinically on the collagen-coated synthetic lenticules.
Human Information Processing with the Personal Memex (2006)

In this report, we describe the work done in a project that explored the human information processing aspects of a personal memex (a memex to organize personal information). In the project, we considered the use of the personal memex, focusing on information recall, by three populations: people with Mild Cognitive Impairment, those diagnosed with Macular Degeneration, and a high-functioning population. The outcomes of the project included human information processing-centered design guidelines for the memex interface, a low-fidelity prototype, and an annotated bibliography for human information processing, usability and design literature relating to the memex and the populations we explored.
Probabilistic model-based clustering of complex data (2003)

In many emerging data mining applications, one needs to cluster complex data such as very high-dimensional sparse text documents and continuous or discrete time sequences.Probabilistic model-based clustering techniques have shown promising results in many such applications.For real-valued low-dimensional vector data, Gaussian models have been frequently used.For very high-dimensional vector and non-vector data, model-based clustering is a natural choice when it is difficult to extract good features or identify an appropriate measure of similarity between pairs of data objects.This dissertation presents a unified framework for model-based clustering based on a bipartite graph view of data and models.The framework includes an information-theoretic analysis of model-based partitional clustering from a deterministic annealing point of view and a view of model-based hierarchical clustering that leads to several useful extensions.The framework is used to develop two new variations of model-based clustering-a balanced model-based partitional clustervi ing algorithm that produces clusters of comparable sizes and a hybrid model-based clustering approach that combines the advantages of partitional and hierarchical model-based algorithms.I apply the framework and new clustering algorithms to cluster several distinct types of complex data, ranging from arbitrary-shaped 2-D synthetic data to high dimensional documents, EEG time series, and gene expression time sequences.The empirical results demonstrate the usefulness of the scalable, balanced model-based clustering algorithms, as well as the benefits of the hybrid model-based clustering approach.They also showcase the generality of the proposed clustering framework.
Quantitation of prostate-specific antigen in serum by a sensitive enzyme immunoassay. (1980)

A sensitive sandwich-type enzyme immunoassay has been developed for quantitation of a human prostate-specific antigen (PA). With this method, PA at a concentration as low as 0.10 ng/ml can be detected. The assay was reproducible as within and between assays yielded a coefficient of variation of 5.7% and 4.6%, respectively. Only human prostate tissues (n = 31) were shown to contain PA. No PA was detected in other human normal or tumor tissues (n = 13). PA was not detectable in sera from normal females (n = 17) or female cancer patients (n = 25). A mean +/- S.D. of 0.47 +/- 0.661 ng/ml (ranging from less than 0.10 to 2.6) ws obtained from a group of 51 normal males. Sera from male patients with nonprostatic cancer contained a similar range of PA as that of normal males. Patients with prostate cancer (371 of 442) and benign prostatic hypertrophy (13 of 19) were shown to have elevated levels of circulating PA. Although no quantitative difference in PA levels was found between the benign prostatic hypertrophy group and Stage A of prostatic cancer, patients with Stages C and D prostatic cancer exhibited significantly elevated levels of PA qualitatively and quantitatively. These results therefore indicate that PA is a histiotypic product of the prostate and may be of use as an adjunctive tool in diagnostic procedures of prostate cancer.
Virtual DSLR: High Quality Dynamic Depth-of-Field Synthesis on Mobile Platforms (2016)

Shallow depth-of-field (DoF) and a smooth bokeh are signature elements of Digital SLR cameras and high-quality lenses. Producing comparable effects on mobile platforms has long been challenging due to small sensor sizes and short focal lengths of mobile cameras. In this paper, we exploit depth sensing capabilities on emerging mobile devices and develop a new depth-guided refocus synthesis technique particularly tailored for mobile devices. Our technique takes coarse depth maps as inputs and applies novel depth-aware pseudo ray tracing. The depth maps can be obtained from mobile depth sensors, mobile stereo cameras and even from user-inputs. Our pseudo ray tracing scheme resembles light field synthesis and refocusing [21] but does not require actual creation of the light field and hence reduces both memory and computational overhead. At the same time, the scheme can overcome boundary bleeding and discontinuity artifacts observed in previous filtering techniques. Comprehensive experiments show that our approach can produce very high quality DoF comparable to the ones produced by DSLR and the Lytro light field cameras.