gebhart/patrepeval huggingface dataset:
The large upstream control region of the <i>Drosophila</i> homeotic gene <i>Ultrabithorax</i> (1991)

Ultrabithorax (Ubx) is a Drosophila homeotic gene that determines the segmental identities of parts of the thorax and abdomen. Appropriate Ubx transcription requires a long upstream control region (UCR) that is defined genetically by the bithoraxoid (bxd) and postbithorax (pbx) subfunction mutations. We have directly analyzed UCR functions by the examination of beta-galactosidase expression in flies containing Ubx-lacZ fusion genes. 35 kb of UCR DNA confers upon beta-galactosidase an expression pattern that closely parallels normal Ubx expression throughout development. In contrast, 22 kb of UCR DNA confers fewer features of normal Ubx expression, and with 5 kb of UCR DNA the expression pattern has no resemblance to Ubx expression except in the visceral mesoderm. We have also shown that bxd chromosome breakpoint mutants form a comparable 5' deletion series in which the severity of the effect on Ubx expression correlates with the amount of upstream DNA remaining in the mutant. In Ubx-lacZ fusions containing 22 kb of UCR DNA, and in comparable bxd mutants, there is a persistent pair-rule pattern of metameric expression in early development, demonstrating that there are distinct mechanisms with different sequence requirements for the initial activation of Ubx in different metameres. The correction of this pair-rule pattern later in embryogenesis shows that there are also distinct mechanisms for the activation of Ubx at different times during development.
Confessions of a Recovering Racist (2006)

Modified deoxynucleosides 2'-deoxy-beta-L-uridine, beta-L-thymidine, alpha-L-thymidine, 2'-deoxy-beta-L-adenosine and 2'-deoxy-alpha-L-adenosine were synthesized and assembled as homooligomers, respectively: octa-beta-L-deoxyuridylates, octa beta-L and alpha-L-thymidylates and tetra beta-L and alpha-L-deoxyadenylates. These unnatural oligomers were then substituted with an acridine derivative. The binding studies of these modified oligonucleotides with D-ribo- and D-deoxyribopolynucleotides were carried out by absorption spectroscopy. While beta-L-d(Up)8m5Acr, beta-L-(Tp)8m5Acr, alpha-L-(Tp)8m5Acr did not interact with poly(rA) and poly(dA), beta-L-d(Ap)4m5Acr and alpha-L-d(Ap)4m5Acr did form double and triple helices with poly(rU) and poly(dT), respectively. Their stability towards nuclease digestion was studied through comparison with that of octa-beta-D-thymidylate and tetra beta-D-deoxyadenylate covalently linked to an acridine derivative. One endonuclease (nuclease P1 from Penicillium citrinum) and two exonucleases (a 3'-exonuclease from Crotalus durissus venom and a 5'-exonuclease extracted from calf thymus) were employed. beta-L- and alpha-L-oligomers demonstrate a high resistance toward nuclease digestion.
Evaluation of NERC's BRD frequency control standard in hydroelectric generation (2015)

During decades of interconnected operation of power systems, frequency control standards have evolved to fairly share the benefits of interconnection and tie-line bias control among Balancing Authorities (BAs). The new draft standards of North American Electric Reliability Council (NERC) define a frequency-dependent Balancing Authority ACE Limit (BAAL) within which BAs must control their Area Control Error (ACE). In this paper, the effects of the new draft standards in real-time Automatic Generation Control (AGC) of a hydroelectric dominated utility are modelled and assessed. Generation scheduling and real-time AGC logic based on taking maximum advantage of new wide bounds of ACE are modelled. It is shown, through dynamic simulations, that generation control under Balance Resource and Demand (BRD) standards is more efficient in term of less generation loss and unit maneuvering.
Time-Resolved Reflectance at Null Source-Detector Separation: Improving Contrast and Resolution in Diffuse Optical Imaging (2005)

We propose a novel approach to imaging in diffusive media based on time-resolved reflectance measurements at null source-detector separation. This approach yields better spatial resolution and contrast as compared to the classical approach, which typically employs a separation of 20-40 mm. Results are obtained by an analytical perturbation approach to diffusion theory and on Monte Carlo simulations. Practical implementation with state-of-the-art technology and performance of a complementary approach based on the use of small but not null source-detector separation are also discussed.
Efficacy and Safety of Mifepristone for the Treatment of Psychotic Depression (2011)

Open-label studies and randomized clinical trials have suggested that mifepristone may be effective for the treatment of major depression with psychotic features (psychotic depression). A recent study reported a correlation between mifepristone plasma concentration and clinical response. The current study aimed to evaluate the safety and efficacy of mifepristone and, secondarily, to test whether response was significantly greater among patients with mifepristone plasma concentrations above an a priori hypothesized threshold. A total of 433 patients who met criteria for psychotic depression were randomly assigned to receive 7 days of either mifepristone (300, 600, or 1200 mg) or placebo. Response was defined as a 50% reduction in psychotic symptoms on both days 7 and 56. Cochran-Mantel-Haenszel tests compared (1) the proportion of responders among patients assigned mifepristone versus placebo and (2) the proportion of responders among the subset of patients with plasma concentrations greater than 1660 ng/mL versus placebo. Mifepristone was well tolerated at all 3 doses. The proportion of responders randomized to mifepristone did not statistically differ from placebo. Patients with trough mifepristone plasma concentrations greater than 1660 ng/mL were significantly more likely to have a rapid and sustained reduction in psychotic symptoms than those who received placebo. The study failed to demonstrate efficacy on its primary end point. However, the replication of a statistically significant linear association between mifepristone plasma concentration and clinical response indicates that mifepristone at sufficient plasma levels may potentially be effective in rapidly and durably reducing the psychotic symptoms of patients with psychotic depression.
Transcription of the Herpes Simplex Virus 1 Genome during Productive and Quiescent Infection of Neuronal and Nonneuronal Cells (2014)

During productive infection, the genes of HSV-1 are transcribed in an ordered cascade. HSV can also establish a more quiescent or latent infection in peripheral neurons. HSV mutants defective in multiple immediate early (IE) genes establish a quiescent infection that models aspects of latency in vivo. We simultaneously quantified the expression of all the HSV genes in nonneuronal and neuronal cells by RNA-seq analysis. The results for productive infection shed further light on the nature of genes and promoters of different kinetic classes. In quiescent infection, there was greater transcription across the genome in neurons than in nonneuronal cells. In particular, the transcription of the latency-associated transcript (LAT), IE genes, and genes in the unique regions adjacent to the repeats persisted in neurons. The relative activity of this region of the genome in the absence of viral activators suggests a more dynamic state for quiescent genomes persisting in neurons.
Bevacizumab in the treatment of ovarian cancer (2007)

Current treatment for epithelial ovarian cancer involves a combination of surgery and chemotherapy with platinum- and taxane-based chemotherapy. With the recent approval of the anti-VEGF antibody bevacizumab by several regulatory bodies in colorectal and non-small-cell lung cancers, interest has developed regarding the potential role of bevacizumab therapy in ovarian cancer. Several case series and Phase II studies indicate that in ovarian cancer bevacizumab is active as a single agent or in combination with other drugs. Currently, ongoing Phase III trials are testing bevacizumab in front-line adjuvant therapy with carboplatin and paclitaxel. Bevacizumab has been generally well tolerated in ovarian cancer patients, but recent reports on increased risk of gastrointestinal perforations have gained attention. Bevacizumab offers a novel therapeutic modality in the treatment of epithelial ovarian cancers.
Micro/Nano-Structured Polypyrrole Surfaces on Oxidizable Metals as Smart Electroswitchable Coatings (2013)

Polypyrrole (PPy) films were electrodeposited from a pyrrole/sodium salicylate solution in water, through two-dimensional (2-D) polystyrene (PS) templates self-assembled on various oxidizable metals, after which the template was removed by dissolution in tetrahydrofuran (THF). The resulting PPy films were analyzed by scanning electron microscopy and atomic force microscopy. Two-dimensional PPy honeycomb structures are obtained on copper or mild steel by using PS spheres of various sizes. The morphology of these structures was controlled electrochemically, as an increase in the polymerization charge does not disturb the PPy honeycomb arrangement, leading instead to the formation of deeper pores accompanied by a change in their diameter. The hydrophobicity of the reduced micro-structured PPy surface is much greater than that of a bulk PPy film generated on the same metal. Reversible electro-switching of the wettability was obtained with marked variation of the apparent contact angle upon PPy oxido-reduction, and an important effect of film micro-structuration upon the wettability range.
Comparison of MOS and Metal-Nitride-Semiconductor Insulated Gate Field-Effect Transistors under Electron Irradiation (1966)

Insulated gate field-effect transistors with silicon dioxide and silicon nitride insulationwere irradiated with 1 MeV electrons over a wide range of biasing conditions. In nitride insulated devices the radiation induced shift in gate turn-onvoltage was greatly reduced and source-drain leakage currents eliminated. The dependence of the equilibrium shift in gate turn-on voltage on gate bias varied critically with the structure of the insulating layer, and an attempt has been made to correlate this with charge transfer mechanisms across the interfaces of the insulator.
Functional modification of biodegradable polyesters through a chemoselective approach: application to biomaterial surfaces (2006)

Abstract This paper presents an overview of functional modifications of synthetic aliphatic polyesters and a new synthetic route to graft functional moieties onto the polyester backbone by a chemoselective approach. Aminooxy groups react efficiently and selectively with ketones or aldehydes to form oxime linkages under mild reaction conditions without catalysts, even in the presence of other functional groups. Chemoselective coupling of aminooxy‐terminated poly(ethylene oxide) (PEO) onto ketone‐bearing poly(ε‐caprolactone) (PCL) was exploited to prepare comb‐shaped copolymers that exhibit cell resistance when the PEO content is above 30 wt%. The free hydroxyl groups of PEO chain ends allowed further incorporation of cell signaling peptides including the sequence RGD. The results show chemoselective coupling to be a promising general route for introducing functional pendant groups onto most polyesters obtained by ring‐opening polymerization without backbone degradation. Copyright © 2006 Society of Chemical Industry
Interaction of vacuum-arc-generated macroparticles with a liquid surface (1998)

The concept of trapping vacuum-arc-generated macroparticles by a liquid is introduced. Experiments have been performed using a pulsed vacuum arc plasma source operating with a carbon cathode. Vacuum pump oil was used as the trapping liquid in vacuum. It was experimentally shown that trapping did not work as anticipated: a substantial number of particles experienced elastic reflection from the liquid surface. With simplified energy and momentum balances it is shown that the liquid behaves increasingly like a solid when the approaching particle is fast. A significant portion of its kinetic energy is transformed into deformation energy which can reappear as kinetic energy of the reflected particle. Particle reflection is likely to be additionally supported by a Leidenfrost-type effect: a thin oil vapor layer of relatively high pressure can be formed between the liquid surface and the macroparticle caused by the macroparticle’s high temperature.
The recovery behavior of semi-insulating GaAs in electron-beam-controlled switches (1990)

Semi-insulating GaAs is experimentally studied with respect to its application in electron-beam-controlled switches. The dark current through the switch is measured both before and after electron-beam irradiation. A lock-on effect, similar to that seen in photoconductive switches, is observed after the electron beam is terminated. This effect is characterized by the switch current continuing to flow, locked to a certain voltage, as long as the voltage is applied across the switch. A possible explanation for this effect, based on the process of electron and hole injection at the contacts, is presented. A method to minimize double injection is offered to make the electron-beam-controlled switch, along with the photoconductive switch, practical for use as both an opening and closing switch.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Syntactic and Structural Pattern Recognition — Theory and Applications (1990)

This book is currently the only one on this subject containing both introductory material and advanced recent research results. It presents, at one end, fundamental concepts and notations developed in syntactic and structural pattern recognition and at the other, reports on the current state of the art with respect to both methodology and applications. In particular, it includes artificial intelligence related techniques, which are likely to become very important in future pattern recognition.The book consists of individual chapters written by different authors. The chapters are grouped into broader subject areas like “Syntactic Representation and Parsing”, “Structural Representation and Matching”, “Learning”, etc. Each chapter is a self-contained presentation of one particular topic. In order to keep the original flavor of each contribution, no efforts were undertaken to unify the different chapters with respect to notation. Naturally, the self-containedness of the individual chapters results in some redundancy. However, we believe that this handicap is compensated by the fact that each contribution can be read individually without prior study of the preceding chapters. A unification of the spectrum of material covered by the individual chapters is provided by the subject and author index included at the end of the book.
Cancer Stem Cells and Aneuploid Populations within Developing Tumors Are the Major Determinants of Tumor Dormancy (2009)

Tumor formation involves substantial cell division and genetic instability, but the relationship between quiescent cancer stem cells (CSC) and dividing progenitors in these events is poorly understood. Likewise, the implication of aneuploid cells in solid tumors is uncertain. CSCs are postulated to contribute to tumor dormancy and present a formidable obstacle in limiting treatment outcomes for a majority of cancers, whereas the genetic heterogeneity conjured by aneuploid cells may influence tumor drug resistance. However, direct confirmation of these events remains forthcoming. In the present study, we addressed the identification of tumor dormancy in terms of isolation of therapy-refractory residual tumor cells from tumors that persist in a state of quiescence as label-retaining cells. The choices of label were PKH67/PKH26 dyes that irreversibly bind to the lipid bilayer on cell membranes and get equally partitioned among daughter cells subsequent to each cell division. Consequent characterization revealed that label-retaining cells encompass two different populations capable of remaining in a state of quiescence, i.e., stem-like cells and aneuploid cells. The former express a reversibility of quiescence through retention of functionality and also exhibit therapeutic refractoriness; the latter seem to be either quiescent or proliferation-arrested at steady-state. Subsequent to exposure to selective pressure of chemotherapy, a fraction of these cells may acquire the potential to proliferate in a drug-refractory manner and acquire stem-like characteristics. Collectively, the findings of the present study reveal that tumor-derived CSCs and aneuploid populations contribute to drug resistance and tumor dormancy in cancer progression.
The Variable-Path Lyman-Alpha Hygrometer and Its Operating Characteristics (1976)

A hygrometer capable of making in situ humidity measurements with good accuracy and excellent time-space resolution is described. Based on the absorption of Lyman-alpha radiation by water vapor, the instrument uses a variable-path technique for achieving long-term stability and is characterized by 12 ms response time, 5% accuracy, 1 cm typical sensing path, and an operating range of −35° to +30°C dew point. The hygrometer is now operational on NCAR aircraft.
Cytochrome P450 2E1 DraI polymorphisms in lung cancer in minority populations. (1998)

Cytochrome P4502E1 (CYP2E1) is involved in the metabolic activation of carcinogenic N-nitrosamines. This study was performed to examine whether CYP2E1 DraI polymorphisms in intron 6 are related to susceptibility to lung cancer and are associated with carcinogenetic exposure. We therefore genotyped CYP2E1 by PCR amplification of peripheral WBC DNA from 126 patients with previously untreated lung cancer (85 African Americans and 41 Mexican Americans) and 193 controls (104 African Americans and 89 Mexican Americans). Mutagen sensitivity was measured with an in vitro assay quantitating bleomycin-induced chromatid breaks in peripheral blood lymphocyte cultures. The CYP2E1 DraI DD genotype was found in 86.5% of all cases and in 74.6% of all controls (P = 0.03), in 78.1% of 41 Mexican-American cases and in 69.6% of their controls (P = 0.70), and in 90.6% of African American cases and in 78.8% of their controls (P = 0.05). The DD genotype was found to be associated with a significantly higher risk of lung cancer overall with an odds ratio (OR) of 2.4 [95% confidence interval (CI), 1.1-5.3]. This risk was significantly elevated for men and for those who had ever smoked [ORs of 3.4 (95% CI, 1.3-8.7) and 2.6 (95% CI, 1.1-6.0), respectively], but not for women and nonsmokers [ORs of 0.7 (95% CI, 0.1-3.8) and 0.9 (95% CI, 0.1-10.6), respectively]. Stratified analysis showed an interaction that seemed greater than multiplicative between cigarette smoking and the CYP2E1 DraI DD genotype. The ORs for the CYP2E1 DraI DD genotype, cigarette smoking, and both risk factors combined were 1.5, 8.5, and 22.7, respectively. The CYP2E1 DraI polymorphism and the CYP2E1 PstI polymorphism in the upstream flanking regions were significantly associated in Mexican Americans but not in African Americans. We therefore conclude that the CYP2E1 DraI polymorphism seems to be associated with lung carcinogenesis. However, a larger study is warranted to evaluate the interactions among CYP2E1 DraI DD genotype, mutagen sensitivity, and cigarette smoking.
The absorption and fluorescence spectra of rare earth ions in silica-based monomode fiber (1988)

Rare-earth ions have been systematically incorporated into the cores of silica-based optical fibers, and the absorption and fluorescence spectra have been measured. The results provide basic data for a wide range of possible future fiber-based devices. For specific telecommunications applications, ions that could be useful for sources in the 1.3- mu m and 1.5- mu m low-loss windows are identified. It is suggested that Er/sup 3+/, Nd/sup 3+/, and Tm/sup 3+/ are the most promising ions for semiconductor pumping with GaAs-based laser diodes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Adaptive video background modeling using color and depth (2002)

A new algorithm for background estimation and removal in video sequences obtained with stereo cameras is presented. Per-pixel Gaussian mixtures are used to model recent scene observations in the combined space of depth and luminance-invariant color. These mixture models adapt over time, and are used to build a new model of the background at each time step. This combination in itself is novel, but we also introduce the idea of modulating the learning rate of the background model according to the scene activity level on a per-pixel basis, so that dynamic foreground objects are incorporated into the background more slowly than are static scene changes. Our results show much greater robustness than prior state-of-the-art methods to challenging phenomena such as video displays, non-static background objects, areas of high foreground traffic, and similar color of foreground and background. Our method is also well-suited for use in real-time systems.
Genome-Scale Compositional Comparisons in Eukaryotes (2001)

We examined dinucleotide relative abundances and their biases in recent sequences of eukaryotic genomes and chromosomes, including human chromosomes 21 and 22, Saccharomyces cerevisiae, Arabidopsis thaliana, and Drosophila melanogaster. We found that dinucleotide relative abundances are remarkably constant across human chromosomes and within the DNA of a particular species. The dinucleotide biases differ between species, providing a genome signature that is characteristic of the bulk properties of an organism's DNA. We detail the relations between species genome signatures and suggest possible mechanisms for their origin and maintenance.
Guide to Microbiological Control in Pharmaceuticals and Medical Devices (2006)

Guide to microbiological control in pharmaceuticals and medical devices , Guide to microbiological control in pharmaceuticals and medical devices , کتابخانه دیجیتال جندی شاپور اهواز
RELATIONSHIPS BETWEEN THE CHEMICAL CONSTITUTION AND FUMIGANT TOXICITY OF THE ALKYL IODIDES (1955)

Nineteen alkyl iodides have been tested as fumigants against the grain weevil, Calandragranaria , using the technique previously described. Relative toxicities, and also the toxicities of mixtures of selected pairs of iodides, were determined. Secondary and tertiary isomers were in general less toxic than the primary, irrespective of whether the toxicity was measured by molar LD 50' or the corresponding relative saturation (Pt/pB) values. Despite differences in LD 50', isomeric primary iodides often acted at about the samep,/p, value. It is suggested that these observations provide evidence that, although chemical reactivity appears to be the principal factor determining the values of LD so's in the iodide series, such physical factors as phase distribution also play their part, and their effect becomes noticeable for the primary isomers, for which the chemical reactivities may be nearly the same. The deaths of individual grain weevils which had been exposed to iodides were more or less delayed. The change of the kill with time was, under standard conditions, the same when all except methyl and the tertiary iodides were used, which suggests that with these possible exceptions, all the iodides have the same type of chemical action on the organisms. The toxicities of mixtures of selected iodides tended to confirm this, for they varied from about 1.0 to 1.25 times the value predicted from the toxicities of the single iodides using the similar action equation. Despite the apparent similarity in mode of action the LD 50's and pt / p8 values varied widely, as did the ratios of the LD 50's of successive homologues in different isomeric series. This suggests that neither the magnitude of the pt / p8 value, nor the way in which it changes from member to member in a series, gives always a useful indication of the type of action shown by a compound or group of compounds.