gebhart/patrepeval huggingface dataset:
Analysis of hydrogen exposure effects on the transmittance of periodic sub-wavelength palladium hole arrays (2009)

In a previous study, we have reported transmittance variations of sub-wavelength palladium hole arrays upon exposure to hydrogen. The main resonance peak of the microfabricated palladium hole arrays exhibiting the extraordinary transmission effect decreases when exposed to the lower flammability concentration of hydrogen in air. This variation in transmittance was attributed to a combination of two effects, namely, a change in the dimension of the array holes due to the expansion of palladium upon hydrogen absorption, and/or a change in the permittivity of the palladium layer upon formation of the palladium hydride phase. In this study, we examine the relative strength of the two effects by finite-difference- time-domain simulation. Our simulation results show that the transmittance variation upon exposure to hydrogen is predominantly caused by the lateral expansion of the palladium layer, which induced a decrease in the hole width of the array.
Acute and Chronic Cycle Length Dependent Increase in Ventricular Pacing Threshold (1992)

Several factors have been shown to influence ventricular pacing threshold in humans, including pacing lead location (endocardial vs epicardial), lead maturation, and antiarrhythmic agents. To determine whether ventricular pacing rate has a significant influence on acute and chronic pacing thresholds, we measured pacing thresholds in 16 patients receiving an implantable antitachycardia pacemaker cardioverter defibrillator (Cadence). Ventricular pacing thresholds were determined using the device programmer at cycle lengths of 600, 400 and 300 msec at the time of implantation; prior to hospital discharge at 3-14 days; and during follow-up outpatient visits at 6-8 weeks, 3 months, and 6 months to 1 year. Eleven patients had an epicardial lead system and five an endocardial lead system. Eleven patients were being treated with antiarrhythmic drug therapy. Device output ranged from 1-10 V and was adjustable in 1-V increments (pulse width was held constant at 1 msec). A cycle length dependent increase in pacing threshold (defined as a > or = 1-V increase in threshold at 400 or 300 msec relative to 600 msec) was observed in 10/16 patients during 12/72 pacing trials at 400 msec, and in 15/16 patients during 31/67 trials at 300 msec. In trials in which an increase in pacing threshold occurred, the magnitude of the increase at 400 msec relative to 600 msec was only 1 V in all 12 trials, but at 300 msec the increase ranged from 4-9 V in 7/31 (23%) trials.(ABSTRACT TRUNCATED AT 250 WORDS)
Deep Learning-Based Recommendation: Current Issues and Challenges (2017)

Due to the revolutionary advances of deep learning achieved in the field of image processing, speech recognition and natural language processing, the deep learning gains much attention. The recommendation task is influenced by the deep learning trend which shows its significant effectiveness and the high-quality of recommendations. The deep learning based recommender models provide a better detention of user preferences, item features and users-items interactions history. In this paper, we provide a recent literature review of researches dealing with deep learning based recommendation approaches which are preceded by a presentation of the main lines of the recommendation approaches and the deep learning techniques. We propose also classification criteria of the different deep learning integration model. Then we finish by presenting the recommendation approach adopted by the most popular video recommendation platform YouTube which is based essentially on deep learning advances.
Acetic acid-promoted condensation of o-phenylenediamine with aldehydes into 2-aryl-1-(arylmethyl)-1H-benzimidazoles under microwave irradiation (2010)

An efficient and simple procedure was developed for the green synthesis of various 2-aryl-1-(arylmethyl)-1H-benzimidazoles in high yields by acetic acid-promoted condensation of o-phenylenediamine with aldehydes in air under microwave irradiation and transition metal catalystfree conditions.
Template-based automatic speech recognition meets prosody (2011)

In this paper, we use prosodic information to improve the accuracy of our template-based automatic speech recognizer. Prosodic information is harvested adopting a data-driven approach. A number of prosodic features is extracted, then combined into major groups, and finally studied separately and together. All acoustic evidence, both segmental and suprasegmental, is modelled non-parametrically. The different sources of information are conveniently combined with segmental conditional random fields. Prosody enhances the accuracy of the state-of-the-art baseline by reducing the word error rate by 7% relative on the nov92, 20k trigram, Wall Street Journal task.
Transcriptional repression by methylation: cooperativity between a CpG cluster in the promoter and remote CpG‐rich regions (1996)

Cytosine methylation of binding sites for transcription factors is a straightforward mechanism to prevent transcription, while data on an indirect mechanism, by methylation outside of the factor binding sites, are still scarce. We have studied the latter effect using a model promoter construct. For this, a 69 bp G + C rich DNA segment with a cluster of 14 CpG sites was inserted between upstream lexA sites and the TATA box. Transcription was measured in transient transfection assays with lexA-VP16 as an activating factor. When the entire plasmid was methylated at all CpGs before transfection, transcription was blocked (to 3% residual activity), whereas transcription was only mildly inhibited (to 60%) by methylation of a control plasmid that lacked the 69 bp CpG cluster. However, the effect could not simply be attributed to methylation of the CpG cluster: neither a methylated CpG cluster in an otherwise methylation-free reporter gene plasmid, nor the methylated plasmid with an unmethylated CpG cluster, inhibited transcription considerably (69% and 44% remaining activity, respectively). The data presented here suggest that a minimal length of methylated DNA in the promoter is required for repression, and imply that concomitant methylation of CpGs in the promoter region and in remote sequences can cooperatively block transcription, without the need to methylate any binding sites for transcription factors. We also note that the cooperation for a negative effect described here bears an analogy to transcriptional activation, where a promoter often cooperates with a remote enhancer.
Influence of Short-Term Octreotide Administration on Chronic Tissue Injury, Transforming Growth Factor beta (TGF-beta) Overexpression, and Collagen Accumulation in Irradiated Rat Intestine. (2001)

The somatostatin analog octreotide was recently found to ameliorate radiation-induced tissue injury in rat intestine. The present study addressed whether octreotide reduces chronic intestinal radiation fibrosis, whether enteroprotection is conferred by direct or indirect mechanisms, and whether the effects are dose-dependent. Using a rat model designed for fractionated irradiation, a segment of small intestine was sham-irradiated or exposed to 67.2 Gy X-radiation in 16 daily fractions. Octreotide (0, 2, or 10 microg/kg/h) was administered subcutaneously by osmotic minipumps for 4 weeks, from 2 days before to 10 days after irradiation. Tissue injury was assessed at 2 weeks (early phase) and 26 weeks (chronic phase) by quantitative histopathology and morphometry. Epithelial and smooth muscle cell proliferation was assessed by proliferating cell nuclear antigen staining; connective tissue mast cell hyperplasia by metachromatic staining; and TGF-beta1 and collagen protein and mRNA by quantitative immunohistochemistry, in situ hybridization, and/or real-time fluorogenic probe reverse transcription-polymerase chain reaction. Octreotide conferred dose-dependent protection against early (p = 0.0003) and chronic (p < 0.0001) tissue injury. Octreotide abrogated radiation-induced chronic increases in extracellular matrix-associated TGF-beta (p < 0.0001), collagen I (p = 0.0001), and collagen III (p = 0.0002) immunoreactivity. Octreotide did not affect radiation-induced changes in steady-state TGF-beta1 mRNA levels, mast cell hyperplasia, or smooth muscle cell proliferation. Octreotide reduced crypt epithelial cell proliferation (p = 0.01), but did not otherwise affect unirradiated intestine. Octreotide confers dose-dependent protection against delayed small bowel radiation toxicity and ameliorates radiation fibrosis predominantly by reducing acute mucosal injury. These data strengthen the rationale for using somatostatin analogs as enteroprotective agents in clinical radiation therapy.
Novel synthesis of branched polystyrenes by quasi‐living radical copolymerization using photofunctional inimer (2001)

Abstract Branched polystyrenes were prepared by quasi‐living radical copolymerization of N,N ‐diethylaminodithiocarbamoylmethylstyrene (inimer: DTCS) with styrene under UV irradiation. DTCS monomers play an important role in this copolymerization system as an inimer capable of initiating living radical polymerization of the vinyl group. Two monomers (DTCS and styrene) showed equal reactivity toward both propagating species, and the copolymer composition was the same as the comonomer feed. This result means that both the branching and chain length of the hyperbranched molecules can be controlled statistically by the feed monomer ratios. The compact nature of the branched macromolecules is demonstrated by viscosity measurements compared to the linear analogues. © 2001 Society of Chemical Industry
A Silencer-Proximal Intronic Region Is Required for Sustained CD4 Expression in Postselection Thymocytes (2014)

It has been proposed that differential kinetics of CD4/CD8 coreceptors regulate fate choice of selected thymocytes. Sustained signals by interaction between MHC class II and TCR/CD4 is required for commitment to the CD4 helper lineage. Although prematurely terminated MHC-TCR/CD4 interaction in transgenic mouse models results in lineage redirection, it is unclear whether CD4 expression is actively maintained by endogenous cis-elements to facilitate prolonged signaling under physiological conditions. In this article, we show that sustained CD4 expression in postselection thymocytes requires an intronic sequence containing an uncharacterized DNase I hypersensitivity (DHS) site located 3' to the silencer. Despite normal CD4 expression before selection, thymocytes lacking a 1.5-kb sequence in intron 1 including the 0.4-kb silencer and the DHS, but not the 0.4-kb silencer alone, failed to maintain CD4 expression upon positive selection and are redirected to the CD8 lineage after MHC class II-restricted selection. Furthermore, CpG dinucleotides adjacent to the DHS are hypermethylated in CD8(+) T cells. These results indicate that the 1.5-kb cis-element is required in postselection thymocytes for helper lineage commitment, presumably mediating the maintenance of CD4 expression, and suggest that inactivation of the cis-element by DNA methylation may contribute to epigenetic Cd4 silencing.
Effective pinhole-collimated ultrasmall-angle x-ray scattering instrument for measuring anisotropic microstructures (2002)

Small-angle scattering is widely used for measuring materials microstructure in the 1–100 nm size range. Ultrasmall-angle x-ray scattering (USAXS), typically achieved through crystal collimation, extends this size range to include features over 1 μm in size. This article reports on USAXS on the UNICAT beam line 33-ID at the Advanced Photon Source. The instrument makes use of a six-reflection crystal pair as a collimator and another six-reflection crystal pair as an analyzer. First principle absolute calibration and a broad scattering vector range make this a very effective instrument, limited only by the fact that the measurement of anisotropic microstructures is excluded due to slit smearing from the crystal collimation. This limitation has recently been removed by adding a horizontally reflecting crystal before and another after the sample. This creates a USAXS instrument with collimation in two orthogonal directions. We call this configuration effective pinhole USAXS. Now, anisotropic materials are probed using 9–17 keV photons in the same physically-relevant (from 50 nm to over 1 μm) microstructural size range as that available for materials which scatter isotropically.
Nanobubbles at the Interface between Water and a Hydrophobic Solid (2008)

A very thin layer (5-80 nm) of gas phase, consisting of discrete bubbles with only about 40 000 molecules, is quite stable at the interface between a hydrophobic solid and water. We prepare this gas phase from either ambient air or from CO(2)(g) through a solvent exchange method reported previously. In this work, we examine the interface using attenuated total internal reflection infrared spectroscopy. The presence of rotational fine structure in the spectrum of CO(2) and D(2)O proves that molecules are present in the gas phase at the interface. The air bubbles are stable for more than 4 days, whereas the CO(2) bubbles are only stable for 1-2 h. We determine the average gas pressure inside the CO(2) bubbles from the IR spectrum in two ways: from the width of the rotational fine structure (P(gas) < 2 atm) and from the intensity in the IR spectrum (P(gas) = 1.1 +/- 0.4 atm). The small difference in gas pressure between the bubbles and the ambient (1 atm) is consistent with the long lifetime. The dimensions and curvature of a set of individual bubbles was determined by atomic force microscopy. The pressures of individual bubbles calculated from the measured curvature using the Laplace equation fall into the range P(gas) = 1.0-1.7 atm, which is concordant with the average pressure measured from the IR spectrum. We believe that the difference in stability of the CO(2) bubbles and the air bubbles is due to a combination of the much lower pressure of CO(2) in the atmosphere and the greater solubility of CO(2) in water, compared to N(2) and O(2). As expected, smaller bubbles have a shorter average lifetime than larger bubbles, and the average pressure and the curvature of individual bubbles decreases with time. Surface plasmon resonance measurements provide supporting evidence that the film is in the gas state: the thin film has a lower refractive index than water, and there are few common contaminants that satisfy this condition. Interfacial gas bubbles are not ubiquitous on hydrophobic solids: bubble-free and bubble-decorated hydrophobic interfaces can be routinely prepared.
Quasi-Solid-State Electrolyte Synthesized Using a Thiol–Ene Click Chemistry for Rechargeable Lithium Metal Batteries with Enhanced Safety (2020)

Liquid electrolytes currently used in lithium-ion batteries have critical drawbacks such as high flammability, high reactivity toward electrode materials, and solvent leakage. To overcome these issues, most recent research has focused on synthesis and characterization of highly conductive gel-type polymer electrolytes containing large numbers of organic solvents in the polymer matrix. There are still many hurdles to overcome, however, before they can be applied to commercial-level lithium-ion batteries. Since a large amount of organic solvent is required to achieve high ionic conductivity, battery safety is not significantly enhanced. In our study, we synthesized highly conductive quasi-solid-state electrolytes (QSEs) containing an ionically conductive oligomer (polycaprolactone triacrylate) and a small amount of organic solvent by employing click chemistry. In the QSE, polycaprolactone participates in dissociation of lithium salt and migration of lithium ions, resulting in high ionic conductivity. The Li/LiNi<sub>0.6</sub>Co<sub>0.2</sub>Mn<sub>0.2</sub>O<sub>2</sub> cell that used this QSE exhibited good cycling performance and enhanced thermal stability, and durability; no organic solvent leakage was observed even under high pressure.
Simultaneous auto‐calibration and gradient delays estimation (SAGE) in non‐Cartesian parallel MRI using low‐rank constraints (2018)

The low-rank based method introduced simultaneously estimates gradient timing delays and provides accurate auto-calibration data for improved image quality, without any additional calibration scans.
Power conscious CAD tools and methodologies: a perspective (1995)

Power consumption is rapidly becoming an area of growing concern in IC and system design houses. Issues such as battery life, thermal limits, packaging constraints and cooling options are becoming key factors in the success of a product. As a consequence, IC and system designers are beginning to see the impact of power on design area, design speed, design complexity and manufacturing cost. While process and voltage scaling can achieve significant power reductions, these are expensive strategies that require industry momentum, that only pay off in the long run. Technology independent gains for power come from the area of design for low power which has a much higher return on investment (ROI). But low power design is not only a new area but is also a complex endeavour requiring a broad range of synergistic capabilities from architecture/microarchitecture design to package design. It changes traditional IC design from a two-dimensional problem (Area/performance) to a three-dimensional one (Area/Performance/Power). This paper describes the CAD tools and methodologies required to effect efficient design for low power. It is targeted to a wide audience and tries to convey an understanding of the breadth of the problem. It explains the state of the art in CAD tools and methodologies. The paper is written in the form of a tutorial, making it easy to read by keeping the technical depth to a minimum while supplying a wealth of technical references. Simultaneously the paper identifies unresolved problems in an attempt to incite research in these areas. Finally an attempt is made to provide commercial CAD tool vendors with an understanding of the needs and time frames for new CAD tools supporting low power design.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Instrumentation for ballistic missile defense: lessons learned from the LEAP experiment (1998)

Integrating instrumentation into complex systems demands careful planning, execution, and testing. Ballistic missile defense is a complex system with many distributed components: radar and imaging sensors, wireless and satellite communications, digital signal processing nodes, interceptor fire control, and command centers. The U.S. Navy has investigated the feasibility of missile defense through the light exo-atmospheric projectile (LEAP) experiment. This paper explains the lessons learned by The Johns Hopkins University Applied Physics Laboratory from building, integrating, and testing instrumentation in the LEAP experiment and give insights for designing complex systems. The biggest challenge in the LEAP experiment involved people: communications between the large number of contractors and their understanding of the interactions between the various instruments. Other concerns included verifying software and system operation, robust data and satellite communications, time and coordinate conversions, and electromagnetic interference. LEAP demonstrated that complex systems, and missile defense system in particular, can only work through careful design, dedicated teamwork, clear and continuous communications, and extensive testing.
Regulation of β‐cell mass and function by the Akt/protein kinase B signalling pathway (2007)

The insulin receptor substrate-2/phosphoinositide 3-kinase (PI3K) pathway plays a critical role in the regulation of beta-cell mass and function, demonstrated both in vitro and in vivo. The serine threonine kinase Akt is one of the promising downstream molecules of this pathway that has been identified as a potential target to regulate function and induce proliferation and survival of beta cells. Here we summarize some of the molecular mechanisms, downstream signalling pathways and critical components involved in the regulation of beta-cell mass and function by Akt.
Investigation of Conducted EMI in SiC JFET Inverters Using Separated Heat Sinks (2013)

This paper systematically investigates the conducted electromagnetic interference (EMI) using separated heat sinks for a silicon carbide (SiC) JFET inverter for motor drives. The inverter circuit layout is implemented with discrete SiC JFETs attached on top of the heat sink, which creates extensive capacitive couplings and moreover increases parasitic oscillations. To minimize the influence, the solution of using separated heat sinks is proposed. For better common mode performance, the high-side heat sink is grounded to avoid fast dv/dts that occur between the drain of the lower switch and the low-side heat sink. For better differential mode performance, the RC snubber circuit and ferrite beads are used to damp parasitic oscillations. Two 2.2 kW inverter prototypes, with six discrete SiC JFETs on one common heat sink and separated heat sinks, respectively, are built using the same circuit layout. Their EMI spectra are compared under unfiltered and filtered conditions. The experiments show that the separate heat sinks inverter system exhibits significantly reduced EMI. Last, three improved solutions are proposed, which effectively suppresses the emitted EMI to the target level.
RFID Coverage Extension Using Microstrip-Patch Antenna Array [Wireless Corner] (2009)

In this paper, a UHF-band 2 times 2 microstrip phased-array antenna is designed and implemented to extend the coverage of an RFID reader system. The phased-array antenna has four microstrip-patch antennas, three Wilkinson power dividers, and a transmission-line phase shifter. These are printed on a dielectric substrate with a dielectric constant of 4.5. The array has dimensions of 34 cm times 45 cm, operating at a frequency of 867 MHz, as specified in RFID Gen2 protocol European standards. The phased-array antenna has a measured directivity of 12.1 dB, and the main-beam direction can be steered to angles of plusmn 40deg, with a HPBW of 90deg. The phased-array antenna is used as the receiving antenna in a commercial reader system. Experimental results indicate that the coverage of the RFID system with the phased-array antenna is superior to the coverage with a conventional broader-beamwidth microstrip-patch antenna. The proposed system can also be used for a wireless positioning system.
Thermal and structural analysis of heparin–PEO–PDMS–PEO–heparin pentablock copolymers (1994)

Abstract ABCBA‐type amphiphilic block copolymers comprising polydimethylsiloxane (PDMS), poly(ethylene oxide) (PEO), and heparin segments were synthesized by coupling reactions between end‐functionalized oligomers. These multiblock copolymers were characterized to examine bulk properties using 1 H‐NMR, FTIR, end‐group analysis, and sulfur elemental analysis. Block copolymers were further characterized in bulk using differential scanning calorimetry and X‐ray diffraction measurements. The PDMS glass transition remains unchanged with increasing PEO content, indicating coexistence of pure PDMS with mixed phases. Furthermore, endothermic melting of the block copolymers shifts to higher temperatures and becomes more intense with increasing PEO molecular weight. Additionally, the crystallinity of the PEO segment in the block copolymers increases with increasing PEO molecular weight. The PEO melting endotherm peak shifts from near 318 to 323 K with annealing. In the cooling thermogram, the block copolymers exhibit two crystallization exotherms, one near 303 K and the other near 193 K, attributed to PEO and PDMS recrystallization and nucleation, respectively. © 1994 John Wiley & Sons, Inc.