gebhart/patrepeval huggingface dataset:
Update on non‐ablative light therapy for rejuvenation: A review (2003)

Non-ablative technologies are playing an increasing role in the management of photoaging. Newer radiofrequency technologies have added to this therapeutic armamentarium. Shorter wavelength technologies are more effective in targeting pilosebaceous vascular and pigmentary alterations while longer wavelength technologies are most effective in wrinkle reduction mediated through dermal remodeling. An overview of the various technologies available to the practicing laser surgeon are outlined in the present review.
Androgens Repress the Expression of the Angiogenesis Inhibitor Thrombospondin-1 in Normal and Neoplastic Prostate (2005)

In order to understand why the angiogenesis inhibitor thrombospondin-1 (TSP1) is often, although not always, associated with prostatic tumors, we have investigated its relationship with the testosterone and the vasculature on which both normal and tumorigenic prostatic epithelia depend. In vivo, androgen withdrawal led to increased TSP1 production and decreased vascularization in the normal rat prostate which was reversed by androgen replacement. Androgen repression of TSP1 production occurred at the transcriptional level and was dependent on the presence of the first intron of the TSP1 gene. In an experimental model of prostate tumorigenesis, TSP1, when delivered by admixed stromal fibroblasts, markedly delayed LNCaP tumor growth and limited tumor vascularization. However, prolonged exposure to TSP1 resulted in the growth of tumors secreting high levels of vascular endothelial growth factor in the bloodstream of tumor-bearing animals and tumor growth was no longer sensitive to TSP1 inhibitory effects. Clinical evidence also suggested that prostate carcinomas are able to adapt to escape the antiangiogenic effects of TSP1. In human androgen-dependent localized prostate carcinomas, TSP1 expression was inversely correlated with blood vessel density. Androgen deprivation in patients with hormone-responsive tumors led to increased TSP1 expression and vascular regression. In contrast, despite a sustained expression in the tumor bed, TSP1 was no longer associated with decreased vascularization in hormone-refractory prostate tumors. Overall, these results suggest that the high in situ TSP1 exposure triggered by androgen deprivation in patients with prostate cancer could lead to early tumor resistance. Such patients could benefit from a combination of androgen deprivation and antiangiogenic therapy in order to minimize the induction of such tumor escape.
Possible involvement of microtubule disruption in bipolar budding of a Sendai virus mutant, F1-R, in epithelial MDCK cells (1993)

Envelope glycoproteins F and HN of wild-type Sendai virus are transported to the apical plasma membrane domain of polarized epithelial MDCK cells, where budding of progeny virus occurs. On the other hand, a pantropic mutant, F1-R, buds bipolarly at both the apical and basolateral domains, and the viral glycoproteins have also been shown to be transported to both of these domains (M. Tashiro, M. Yamakawa, K. Tobita, H.-D. Klenk, R. Rott, and J.T. Seto, J. Virol. 64:4672-4677, 1990). MDCK cells were infected with wild-type virus and treated with the microtubule-depolymerizing drugs colchicine and nocodazole. Budding of the virus and surface expression of the glycoproteins were found to occur in a nonpolarized fashion similar to that found in cells infected with F1-R. In uninfected cells, the drugs were shown to interfere with apical transport of a secretory cellular glycoprotein, gp80, and basolateral uptake of [35S]methionine as well as to disrupt microtubule structure, indicating that cellular polarity of MDCK cells depends on the presence of intact microtubules. Infection by the F1-R mutant partially affected the transport of gp80, uptake of [35S]methionine, and the microtubule network, whereas wild-type virus had a marginal effect. These results suggest that apical transport of the glycoproteins of wild-type Sendai virus in MDCK cells depends on intact microtubules and that bipolar budding by F1-R is possibly due, at least in part, to the disruption of microtubules. Nucleotide sequence analyses of the viral genes suggest that the mutated M protein of F1-R might be involved in the alteration of microtubules.
Oxidant Stress Enhances Adenylyl Cyclase Activation (1995)

The generation of oxygen-derived free radicals has been implicated in the disordered vascular regulation of inflammation and reperfusion. In the vasculature, oxygen-derived free radicals are vasodilatory. The mechanisms underlying this effect remain unclear. To examine the cellular processes involved, we studied the effects of hydrogen peroxide (H2O2) on adenylyl cyclase activity in A10 cells, a murine vascular smooth muscle cell line. Pretreatment with H2O2 caused a dose-dependent enhancement of forskolin-stimulated adenylyl cyclase activity (ED50, 44 mumol/L to a maximum of 166% of control activity; n = 4). This enhancement was attenuated by iron chelation with deferoxamine and by the intracellular hydroxyl scavenger dimethylthiourea and mimicked by preincubation with purine/xanthine oxidase either alone or in the presence of superoxide dismutase. The effects of H2O2 were completely blocked by the tyrosine kinase inhibitors genistein and tyrphostin A9 but not by its inactive analogue tyrphostin A1 (H2O2 alone, 149 +/- 13%; H2O2 + tyrphostin A9, 100 +/- 9%; H2O2 + tyrphostin A1, 171 +/- 21%; n = 4). H2O2 comparably enhanced adenylyl cyclase activity stimulated by isoproterenol (166 +/- 17% of control, n = 5) and sodium fluoride (177 +/- 18% of control, n = 5). Thus oxygen-derived free radicals enhance adenylyl cyclase activation, probably via tyrosine kinase-mediated effects on the catalytic subunit of adenylyl cyclase. Sensitization of adenylyl cyclase activation may be an important mechanism by which free radicals modulate hormone-mediated vasodilation.
Immunohistochemical localization of defensin in human coronary vessels. (1997)

Neutrophil defensins comprise a family of cationic peptides that possess potent antimicrobial activity. Defensins are normally sequestered in cytoplasmic granules with their primary site of action in phagolysosomes, although some peptide is released into the circulation during the course of infection or inflammation. In view of the fact that neutrophils adhere to the endothelium and that defensins have been reported to bind to human endothelial cells in vitro, we used immunohistochemistry to study the distribution of these peptides in normal and in atherosclerotic human coronary arteries. Defensin was found primarily in the intima of normal and atherosclerotic vessels, most prominently in association with intimal smooth muscle cells. Both large- and small-vessel endothelium stained focally for defensin. Defensin was also found in the media near the external elastic lamina and in some periadventitial vessels. The same distribution was seen in vessels that had been perfusion fixed immediately upon procurement, excluding diffusion of defensin from PMNs ex vivo. These data indicate that neutrophil defensin is present in the walls of human coronary arteries. The deposition of defensin in vessels may contribute to the pathophysiological consequences of inflammation in addition to their role in host defense.
SO(2) and SO(3), omni-directional personal mobility with link-driven spherical wheels (2011)

There are many researches about mobile robot with a varied wheel. Mobile robots or mobilities with wheels such like a car or bike have non-holonomic constraint and then it is difficult to move toward wheel's axis direction. Namely, it is impossible to move toward omni-direction due to the constraints by wheel's mechanical structure. Omni-directional movement means the mobility can move toward any direction at anytime. This paper adapted link-driven spherical wheel as an omnidirectional wheel and solved singularity problem caused by mechanical structure of it. We developed omni-directional mobilities( SO(2) and SO(3)) installing link-driven spherical wheels and experimented omni-directional movement with designed controllers.
On opening PSTN to enhanced voice/data services-The PINT Protocol Solution (2002)

This paper describes the original PSTN/Internet INTernetworking (PINT) model, as defined by its namesake working group in the Internet Engineering Task Force (IETF). It then focuses on the building blocks from which a broad range of intelligent network (IN)-initiated services can be built. The PINT approach systematically uses the IN as the means of uniting the public switched telephone network (PSTN) and the Internet, which is natural since intelligent networking is a data communications technology. One goal of this paper is to show how the PINT initiative is bringing network intelligence to the edge of the network.
An Optimal Adaptation Framework for Streaming Multiple Video Objects (2008)

With multi-angle video contents available at a user terminal, the user can select his/her preferred alternate views among the given multiple video streams captured at different view angles for a same event. This enhanced experience often entails streaming problems in real-time over the network. In order to cope with this problem, multi-angle video contents are encoded at different bit rates and the appropriate video streams are then selected or transcoded for delivery to meet such bandwidth constraints. Therefore, the selection and transcoding operations become essential processing steps to adapt to the time-varying bandwidth of the network. In this paper, we propose an optimal adaptation framework for streaming multiple video streams by jointly formulating the selection and transcoding problems into a unified optimization problem.
Amphotericin B cochleates: a vehicle for oral delivery. (2004)

Cochleates are a novel lipid-based delivery vehicle consisting of crystalline phospholipid-cation structures that form spiral lipid sheets. They represent a new technology platform for oral delivery of clinically important drugs that possess poor oral bioavailability. Orally administered cochleates containing amphotericin B (CAMB) showed broad-spectrum activity in murine infection models of candidiasis, aspergillosis and cryptococcosis. Initial biodistribution studies of CAMB administered orally in mice demonstrated that cochleates delivered significant levels of AMB to target organs. The lipid particulate nature of cochleates also imparted reduced toxicity that mimics other lipid-amphotericin B complexes. Cochleates are a promising new vehicle for oral delivery of amphotericin B at therapeutic levels.
Time‐lapse down‐hole seismic surveys for deep EOR target monitoring in South Oman (2011)

A time‐lapse borehole seismic monitoring program was executed in a pilot steam injection pattern in field ‘X’ in South Oman. The program involved baseline and repeat acquisition of 3DVSP and multi‐profile cross‐well seismic. The down‐hole surveys allowed us to see time‐lapse changes in 3DVSP reflection images, cross‐well tomography and cross‐well reflection images. It was important to develop time‐lapse processing workflows for these three techniques. Cross‐well processing required reliable data selection, and 3DVSP required noise removal and data matching. The cross‐well and 3DVSP data indicate a preferential direction for time‐lapse anomaly development which is broadly consistent with temperature surveys and top reservoir relief. However, the details of the anomaly visible on 3DVSP, cross‐well tomography and cross‐well imaging are different and integration of these results is required to understand the anomaly better. 3DVSP should be considered as an option for targeted onshore monitoring, as the images are very repeatable after careful time‐lapse processing. Cross‐well surveys are sensitive to small velocity changes and impedance changes over thin zones, as they occur in the early stages of field production.
Krylov subspace iterative techniques: on the detection of brain activity with electrical impedance tomography (2002)

In this paper, we review some numerical techniques based on the linear Krylov subspace iteration that can be used for the efficient calculation of the forward and the inverse electrical impedance tomography problems. Exploring their computational advantages in solving large-scale systems of equations, we specifically address their implementation in reconstructing localized impedance changes occurring within the human brain. If the conductivity of the head tissues is assumed to be real, the pre-conditioned conjugate gradients (PCGs) algorithm can be used to calculate efficiently the approximate forward solution to a given error tolerance. The performance and the regularizing properties of the PCG iteration for solving ill-conditioned systems of equations (PCGNs) is then explored, and a suitable preconditioning matrix is suggested in order to enhance its convergence rate. For image reconstruction, the nonlinear inverse problem is considered. Based on the Gauss-Newton method for solving nonlinear problems we have developed two algorithms that implement the PCGN iteration to calculate the linear step solution. Using an anatomically detailed model of the human head and a specific scalp electrode arrangement, images of a simulated impedance change inside brain's white matter have been reconstructed.
The calmodulin-binding site in alpha-fodrin is near the calcium-dependent protease-I cleavage site. (1988)

Fodrin (brain spectrin) binds calmodulin and is susceptible to proteolysis by calcium-dependent protease I (CDP-I, calcium-activated neutral protease I, or calpain I). Both events involve the central region of the alpha-fodrin subunit, and calmodulin binding enhances the sensitivity of fodrin to CDP-I mediated proteolysis. Fragments of fodrin, generated chemically or proteolytically, which retain calmodulin binding activity have been identified and analyzed by two-dimensional peptide mapping and by direct protein sequencing. Both CDP-I and calmodulin interact with the terminal portion of the eleventh repetitive unit in fodrin, which is at the center of the molecule. CDP-I cleavage occurs between Tyr104 and Gly105 and preserves the calmodulin binding activity of the carboxyl-terminal fragment. In contrast, chymotryptic cleavage at Trp120 reduces the ability of this fragment to bind calmodulin, and tryptic cleavage beyond Trp120 completely eliminates calmodulin binding activity. It is concluded that Ser-Lys-Thr-Ala-Ser-Pro-Trp-Lys-Ser-Ala-Arg-Leu-Met-Val-His-Thr-Val-Ala- Thr- Phe-Asn-Ser-Ile-Lys, a 24-residue peptide which bridges repeats 11 and 12 of brain alpha spectrin contains the high affinity calmodulin binding domain.
Alignment, classification, and three-dimensional reconstruction of single particles embedded in ice. (1992)

Cryo-electron microscopy of single biological particles poses new challenges to digital image processing due to the low signal-to-noise ratio of the data. New tools have been devised to deal with important aspects of 3-D reconstruction following the random-conical data collection scheme: (a) a new shift-invariant function has been derived, which promises to facilitate alignment and classification of single particle projections; (b) a new method of orientation search is proposed, which makes it possible to relate random-conical data sets to one another prior to reconstruction; and (c) the foundation is laid for a 3-D variance estimation which utilizes the oversampling of 3-D angular space by projections in the random-conical reconstruction scheme.
Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3 (2004)

Signal transducer and activator of transcription 5 (STAT5) plays a critical role in cytokine-induced survival of hematopoietic cells. One of the STAT5 target genes is pim-1, which encodes an oncogenic serine/threonine kinase. Here we demonstrate that Pim-1 inhibits STAT5-dependent transcription in cells responsive to interleukin-3, prolactin, or erythropoietin. Ectopic expression of Pim-1 in cytokine-dependent FDCP1 myeloid cells results in reduced tyrosine phosphorylation and DNA binding of STAT5, indicating that Pim-1 interferes already with the initial steps of STAT5 activation. However, the Pim-1 kinase does not directly phosphorylate or bind to STAT5. By contrast, Pim-1 interacts with suppressor of cytokine signaling 1 (SOCS1) and SOCS3 and potentiates their inhibitory effects on STAT5, most likely via phosphorylation-mediated stabilization of the SOCS proteins. Thus, both Pim and SOCS family proteins may be components of a negative feedback mechanism that allows STAT5 to attenuate its own activity.
Measurement and analysis of OSN ad auctions (2014)

Advertising is ubiquitous on the Web; numerous ad networks serve billions of ads daily via keyword or search term auctions. Recently, online social networks (OSNs) such as Facebook have created site-specific ad services that differ from traditional ad networks by letting advertisers bid on users rather than keywords. With Facebook's annual ad revenue exceeding $4 billion, OSN-based ad services are emerging to be a significant fraction of the online ad market. In contrast to other online ad markets (e.g., Google's ad market), there has been little academic study of OSN ad services, and OSNs have released very little data about their advertising markets; as a result, researchers currently lack the tools to measure and understand these markets.
Architecture of Web-EDA system based on Cloud computing and application for project management of IC design (2010)

Cloud computing is usually defined to deliver infrastructure, platform and software as services, which is available as a pay-as-you-go model for users. A paradigm of Cloud computing for EDA service is presented in this paper, and a hierarchical architecture of Web-EDA system implemented with Cloud computing is described in detail. Based on this proposed system structure, we developed a prototype of the Web-EDA system for sharing EDA Tools and project management of IC design. It shows that Cloud computing for EDA service is possible to be implemented distributedly and brings maximum benefit to both users and vendors.
Structure of Ge(100) Surfaces for High- Efficiency Photovoltaic Applications (1998)

While much is known about the Ge(100) surface in a UHV/MBE environment, little has been published about this surface in an MOCVD environment. The main objective of this study is to determine the structure of the surface of Ge substrates in the typical MOCVD reactor immediately prior to and following the heteronucleation of GaAs and other lattice-matched III-V alloys, and to determine the conditions necessary for the growth of device-quality epilayers. In this paper the authors present the first STM images of the MOCVD-prepared Ge surfaces. Although many of the observed features are very similar to UHV- or MBE-prepared surfaces, there are distinct and important differences. For example, while the As-terminated surfaces for MBE-Ge and MOCVD-Ge are virtually identical, the AsH{sub 3}-treated surfaces in an MOCVD reactor are quite different. The terrace reconstruction is rotated by {pi}/2, and significant step bunching or faceting is also observed. Time-dependent RD kinetic studies also reveal, for the first time, several interesting features: the transition rate from an As-terminated (1 x 2) terrace reconstruction to a stable AsH{sub 3}-annealed surface is a function of the substrate temperature, substrate miscut from (100) and AsH{sub 3} partial pressure, and, for typical prenucleation conditions, is relatively slow. These results explain many of the empirically derived nucleation conditions that have been devised by numerous groups.
Thomas Amory (1937)

Thomas Amory Get access E. G. B E. G. B Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 173, Issue 12, 18 September 1937, Page 213, https://doi.org/10.1093/nq/173.12.213b Published: 18 September 1937
Comparative Validity of 3 Diabetes Mellitus Risk Prediction Scoring Models in a Multiethnic US Cohort: The Multi-Ethnic Study of Atherosclerosis (2010)

Several models for estimating risk of incident diabetes in US adults are available. The authors aimed to determine the discriminative ability and calibration of published diabetes risk prediction models in a contemporary multiethnic cohort. Participants in the Multi-Ethnic Study of Atherosclerosis without diabetes at baseline (2000-2002; n = 5,329) were followed for a median of 4.75 years. The predicted risk of diabetes was calculated using published models from the Framingham Offspring Study, the Atherosclerosis Risk in Communities (ARIC) Study, and the San Antonio Heart Study. The mean age of participants was 61.6 years (standard deviation, 10.2); 29.3% were obese, 53.1% had hypertension, 34.9% had a family history of diabetes, 27.5% had high triglyceride levels, 33.8% had low high density lipoprotein cholesterol levels, and 15.3% had impaired fasting glucose. There were 446 incident cases of diabetes (fasting glucose level >or=126 mg/dL or initiation of antidiabetes medication use) diagnosed during follow-up. C statistics were 0.78, 0.84, and 0.83 for the Framingham, ARIC, and San Antonio risk prediction models, respectively. There were significant differences between observed and predicted diabetes risks (Hosmer-Lemeshow goodness-of-fit chi-squared test for each model: P < 0.001). The recalibrated and best-fit models achieved sufficient goodness of fit (each P > 0.10). The Framingham, ARIC, and San Antonio models maintained high discriminative ability but required recalibration in a modern, multiethnic US cohort.
A method for characterizing sarcoma tumor boundary scanned with T2-weighted MRI (2011)

Purposes: Analysis of the tumor boundary could play an important role in increasing the understanding of tumor relationships with normal structures for surgical resection planning and risk assessment for local recurrence in sarcoma. The objective of this paper is to present analytical methods that were developed to characterize the tumor boundary using the signal from T2-weighted MRI in a test set of images from patients with sarcomas. Patients and Methods: The study MRI parameters were compared to histopathological data from the resected tumors. T2-weighted scans were acquired from 20 subjects from patients diagnosed with sarcoma. Computer software was developed to characterize the MR intensity of the tumor boundary as function of distance along probing radii. Results: There were significant differences in the MRI tumor boundary parameters between tumors resected with positive or negative margins. The slope of the T2 signal change at the tumor/normal tissue boundary (p=0.007) and boundary distance (p=0.001) were significantly correlated with tumor margin status. Conclusions: These data demonstrate that this image analysis algorithm which characterizes the change in MR signal at the tumor boundary could be useful in the clinical evaluation of the tumor. The spatial position of this MR signal slope parameter that correlates with positive tumor margins can be identified precisely while the tumor is still in the body of the patient prior to tumor removal. This boundary analysis method which is different than simple edge detection reports on the tumor-normal tissue interface.