gebhart/patrepeval huggingface dataset:
A 2,3‘-Substituted Biphenyl-Based Amino Acid Facilitates the Formation of a Monomeric β-Hairpin-like Structure in Aqueous Solution at Elevated Temperature (1996)

An evaluation of [3‘-(2-aminoethyl)-2-biphenyl]propionic acid (1) and 2-amino-3‘-biphenylcarboxylic acid (2) as β-sheet nucleators was accomplished by incorporating these residues into water soluble peptides. Residue 1 was designed to replace the backbone of the i + 1 and i + 2 residues of a β-turn and reverse the polypeptide chain direction via a hydrogen-bonded hydrophobic cluster to initiate β-hairpin folding. An NMR structural evaluation of heptapeptides incorporating 1 revealed the presence of a hydrophobic cluster involving an aromatic ring of 1 and a side chain of one of the flanking hydrophobic α-amino acids, even though the peptides lack sufficient length to adopt a β-sheet structure. The flanking α-amino acid residues in these peptides exhibit significantly slower amide proton/deuterium exchange rates, indicating that they are intramolecularly hydrogen bonded in aqueous solution. In appropriate tridecapeptides, the hydrogen-bonded hydrophobic cluster nucleates the formation of a β-hairpin structure which subsequently self-associates. Unlinking the intramolecular folding and self-association equilibria was accomplished by strategically replacing two of the exterior amide protons in the tridecapeptide with methyl groups. These tertiary amide groups cannot act as hydrogen bond donors and sterically block the intermolecular β-sheet interactions between exterior β-strands, preventing self-assembly. The N-methylated tridecapeptide incorporating 1 has been characterized by analytical equilibrium ultracentrifugation, far-UV CD, FT-IR, and a variety of NMR experiments which support a β-hairpin-like structure. Interestingly, these peptides exhibit an increase in β-sheet structure with increasing temperature which may prove to be general for β-sheets stabilized by hydrophobic interactions. The incorporation of residue 2 into an identical α-amino acid sequence does not result in folding under the same conditions, implying that the hydrogen-bonded hydrophobic cluster promoted by 1 is required for β-hairpin folding.
New constraining method for partitioned block frequency-domain adaptive filters (2002)

For adaptive filters with many taps, a short processing delay, and relative low computational complexity, the partitioned block frequency-domain adaptive filter (PBFDAF) is a good choice. The computational complexity of this algorithm is significantly reduced by using the alternated constrained PBFDAF. This particular algorithm applies gradient constraints in an alternating manner. In this paper, a serious problem in performance of the alternated constrained PBFDAF is described. Furthermore, a modification is proposed that effectively alleviates this problem. By using this modification together with a gradient constraint approximation, a new efficient alternated constrained PBFDAF is developed. Compared with the fully constrained PBFDAF, this new constraining method does not show any significant performance loss and still has a much smaller computational complexity.
Possible Realization of Directional Optical Waveguides in Photonic Crystals with Broken Time-Reversal Symmetry (2008)

We show how, in principle, to construct analogs of quantum Hall edge states in "photonic crystals" made with nonreciprocal (Faraday-effect) media. These form "one-way waveguides" that allow electromagnetic energy to flow in one direction only.
Update on the clinical management of Wilson&#39;s disease (2017)

Wilson's disease (WD), albeit relatively rare, is an important genetic metabolic disease because of highly effective therapies that can be lifesaving. It is a great imitator and requires a high index of suspicion for correct and timely diagnosis. Neurologic, psychiatric and hepatologic problems in WD are very nonspecific, and we discuss the most common clinical phenotypes. The diagnosis remains laboratory based, and here we review the most important challenges and pitfalls in laboratory evaluation of WD, including the emerging role of genetic testing in WD diagnosis. WD is a monogenic disorder but has very high allelic heterogeneity with >500 disease-causing mutations identified, and new insights into phenotype-genotype correlations are also reviewed. The gold standard of therapy is chelation of excessive copper, but many unmet needs exist because of possible clinical deterioration in treated patients and potential adverse effects associated with currently available chelating medications. We also review the most promising novel therapeutic approaches, including chelators targeting specific cell types, cell transplantation and gene therapy.
Interplay between lipoproteins and bee venom phospholipase A2 in relation to their anti-plasmodium toxicity (2006)

We previously showed that the in vitro intraerythrocytic development of the malarial agent Plasmodium falciparum is strongly inhibited by secreted phospholipases A(2) (sPLA(2)s) from animal venoms. Inhibition is dependent on enzymatic activity and requires the presence of serum lipoproteins in the parasite culture medium. To evaluate the potential involvement of host lipoproteins and sPLA(2)s in malaria, we investigated the interactions between bee venom phospholipase A(2) (bvPLA(2)), human triglyceride-rich lipoproteins, and infected erythrocytes. Even at high enzyme concentration (100x IC(50)), bvPLA(2) binding to Plasmodium-infected or normal erythrocytes was not detected. On the contrary, tight association with lipoproteins was observed through the formation of buoyant bvPLA(2)/lipoprotein complexes. Direct involvement of the hydrolysis lipid products in toxicity was demonstrated. Arachidonic acid (C20:4), linoleic acid (C18:2), and, to a lesser extent, docosahexaenoic acid (C22:6) appeared as the main actors in toxicity. Minimal oxidation of lipoproteins enhanced toxicity of the lipolyzed particles and induced their interaction with infected or normal erythrocytes. Fresh or oxidized lipolyzed lipoproteins induced the parasite degeneration without host cell membrane disruption, ruling out a possible membranolytic action of fatty acids or peroxidation products in the death process. In conclusion, our data enlighten on the capability of secreted PLA(2)s to exert cytotoxicity via the extracellular generation of toxic lipids, and raise the question of whether such mechanisms could be at play in pathophysiological situations such as malaria.
Estimation of Induction Machine Parameters from Standstill Time-Domain Data (1994)

This paper presents a step-by-step approach to identifying the parameters of an induction machine from standstill time-domain test data. A step voltage disturbance is applied across the stator terminals while the machine is in the standstill condition, and the resulting stator voltage and current responses are measured. The initialization of the transfer function model parameters is achieved by the Laplace transformation of the recorded time-response data, and the maximum likelihood (ML) method is used for both the transfer function and the equivalent-circuit-model parameter estimation. Based on the identified models, simulation studies are performed and compared to the measured standstill time-domain response, the standstill frequency response (SSFR), and the free-acceleration response to validate the identified models.
The solubility of heavy metal soaps in co‐solvent mixtures of chloroform and propylene glycol (1947)

Summary The solubilities of the myristates, laurates, palmitates, and stearates of magnesium, lead, calcium, barium, and zinc have been measured at 25° C. in chloroform and in propylene glycol and in their mixtures. Even where they are sparingly soluble in the solvents separately, they dissolve freely in mixtures of the two. For each metal the solubility is greatest for laurate and least for stearate and it is very low for zinc soaps, particularly zinc stearate. Heavy metal soaps may be directly titrated with acid in mixtures of propylene glycol and chloroform using thymol blue as indicator (yellow to pink).
Reanalysis of Energy Spectrum and Composition in the DICE Experiment (2001)

Abstract. Possible systematic errors in the DICE energy spectrum and composition results are explored. The cor-rected data will be presented at the conference. 1
Functional analysis of anterior cruciate ligament instability (1986)

Eighteen males and two females (mean age, 26.5 years) underwent biomechanical assessment and Cybex evaluation prior to ACL reconstruction. Clinically, all patients had at least a 1+ grade with the Lachman, anterior drawer, and pivot shift tests, the majority being graded as 2+. Footswitch, high speed photography, force plate, and indwelling wire electrode data were collected while each subject performed free and fast walking, running, cutting, and stair climbing activities. During walking, single limb support times did not differ between the subject's involved and uninvolved limbs. Knee joint angles were similar between limbs during walking, running, and stair climbing maneuvers. Dynamic EMG tracings during walking demonstrated similar quadriceps and calf activity between limbs, while greater variation in hamstring firing was evident among subjects. During running, the involved limb had a longer duration of medial hamstring activity compared to the lateral hamstring. No significant differences were seen in either vertical or sagittal shear forces during free walking. During fast walking, higher midstance vertical forces (F2) were present in the involved limb (P less than 0.05). During running, the involved limb experienced lower vertical forces (P less than 0.05), while both anterior and posterior sagittal shear differences were insignificant. Straight cut maneuvers demonstrated significantly lower lateral shear and vertical forces in the involved limb (P less than 0.05). Lower lateral and sagittal shear forces in the involved limb (P less than 0.01 and P less than 0.05, respectively), combined with a reduced angle of the cut during the cross-cut maneuver, may be the first means to assess the functional pivot shift phenomenon ever documented.(ABSTRACT TRUNCATED AT 250 WORDS)
Mannitol Metabolism in Agaricus bisporus: Purification and Properties of Mannitol Dehydrogenase (1985)

Summary: Mannitol dehydrogenase (EC 1.1.1.138) has been purified to homogeneity from fruit bodies of Agaricus bisporus. M r values of 115000 were determined by gel filtration and 130000 by rate zonal ultracentrifugation. The sedimentation coefficient is 6.5S. The native protein is composed of four subunits of M r 29000. The enzyme is specific for NADP, and shows low activity with sorbitol. Normal Michaelis-Menten kinetics are exhibited for both mannitol and NADP, giving K m values of 16.2 mm and 36μm respectively at pH 7.0. The K m value for NADPH is 38.5μm and that for fructose approximately 1.2 m. The V max is 591 μm min−1 (mg protein)−1 for mannitol synthesis and 5μmol min−1 (mg protein)−1 for fructose synthesis at pH 7.0. Inhibition of fructose synthesis by NADPH is stronger than inhibition of mannitol synthesis by NADP. The results are discussed with respect to the control of enzyme activity under physiological conditions.
In vitro activities of two new antifungal azoles (1984)

The antifungal activities of equimolar quantities of three azole compounds, Bay n 7133 [1-(4-chlorophenoxy)-3,3-dimethyl-2-(1,2,4-triazole-1-yl)methylbutan-2-O1], Bay 1 19139 [1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanol hydrochloride], and ketoconazole, were compared by testing the susceptibility in vitro of 10 clinical isolates each of Candida albicans, Candida parapsilosis, Torulopsis glabrata, Cryptococcus neoformans, Aspergillus fumigatus, Aspergillus niger, Aspergillus flavus, Rhizopus spp., Mucor spp., and Coccidioides immitis. Molecule for molecule, ketoconazole was consistently the most active drug. All three azoles were primarily fungistatic, although they were fungicidal at clinically relevant concentrations against some strains of A. niger.
SnO/sub 2/ sensors with variable operating temperature for CO detection: selectivity enhancement (2003)

SnO/sub 2/ sensors are widely used for the detection of air contaminants such as CO. Nevertheless, their application encounters many problems, first of all the effect of interfering gases. The low selectivity is in fact a well-known problem of these sensors. Moreover, the high operating temperature of metal oxide sensors implies in general high power consumption. In this work we present a study aimed at the selection of an appropriate measurement technique for the detection of CO for indoor applications (100 ppm CO), also in presence of high concentrations of ethanol (1000 ppm C/sub 2/H/sub 5/OH). Moreover, the work aims at developing very low size and power consumption devices, that could be battery operated, to be used for the development of portable CO detectors.
A Study on Green Algae Monitoring in Watershed Using Fixed Wing UAV (2017)

본 연구는 지속적으로 수계 내 녹조를 모니터링할 수 있도록 고정익 무인비행기에 멀티스펙트럴 센서를 탑재시켜 금강 유역의 하천을 촬영하고, NDVI 분석을 수행함으로써 수계환경을 효율적으로 관리하는 것을 목적으로 하고 있다. 연구 대상지역은 금강 유역의 백제보 인근이며, 연구수행에 사용된 데이터는 녹조 발생 초기인 2016년 7월에 촬영된 영상이다. 데이터 처리과정으로서, Pix4D 소프트웨어를 이용하여 NDVI 영상을 생성하는 작업을 수행하였다. 생성된 NDVI 영상을 클로로필 실측값과 비교하여 관계식을 도출하고 영상 수치 변환 작업을 수행하였다. 그 결과 실측값이 반영된 클로로필 영상을 추출할 수 있었으며, 앞으로 수계환경관리를 위한 녹조 관측 및 모니터링, 그리고 재해예방 측면에서 무인비행기를 이용한 클로로필 정보 취득은 매우 유용할 것으로 판단된다. The primary purpose of this study is to determine NDVI analysis methodologies for green algae monitoring system. A fixed wing UAV integrated with multi-spectral sensor has been adopted to capture the images along the watershed in Gumgang River. The study area was near the Baekje water reservoir and the images was captured on July 2016. Pix4D Mapper Pro was used to process the captured images. Through the comparison actual chlorophyll measurement values with NDVI output image, empirical formula was suggested and geo-locational conversion was carried out. As a result of this study chlorophyll image set applied to actual measurement values was able to extracted. For the efficient management of green algae, its monitoring and prevention in terms of disaster management, gathering chlorophyll information using UAV is very beneficial.
WFSBP guidelines on how to grade treatment evidence for clinical guideline development (2018)

Further, these updated WFSBP recommendations for rating evidence and treatment recommendations provide a grading system that takes into account potential biases in sources of evidence in arriving at final ratings that are likely more clinically meaningful and pragmatic and thus should be used for the development of future treatment guidelines.
Effective latent space graph-based re-ranking model with global consistency (2009)

Recently the re-ranking algorithms have been quite popular for web search and data mining. However, one of the issues is that those algorithms treat the content and link information individually. Inspired by graph-based machine learning algorithms, we propose a novel and general framework to model the re-ranking algorithm, by regularizing the smoothness of ranking scores over the graph, along with a regularizer on the initial ranking scores (which are obtained by the base ranker). The intuition behind the model is the global consistency over the graph: similar entities are likely to have the same ranking scores with respect to a query. Our approach simultaneously incorporates the content with other explicit or implicit link information in a latent space graph. Then an effective unified re-ranking algorithm is performed on the graph with respect to the query. To illustrate our methodology, we apply the framework to literature retrieval and expert finding applications on DBLP bibliography data. We compare the proposed method with the initial language model method and another PageRank-style re-ranking method. Also, we evaluate the proposed method with varying graphs and settings. Experimental results show that the improvement in our proposed method is consistent and promising.
La Gestión Ambiental (2006)

Aquest text tanca la sèrie iniciada amb l'article Orígens de la problemàtica Ambiental, al que l'autor plantejava la problemàtica ambiental des d'una perspectiva de relació entre subsistemes (natural i social). Seguint en la mateixa línia, ara Muriel argumenta que la naturalesa és objecte i els humans objecte-subjecte de la gestió ambiental. És a dir, que de la nostra actuació com a subjectes depèn la sostenibilitat de la naturalesa i de la societat, ambdós objectes de la gestió.
Molecular comparison of GLT1 <sup>+</sup> and ALDH1L1 <sup>+</sup> astrocytes <i>in vivo</i> in astroglial reporter mice (2010)

Astrocyte heterogeneity remains largely unknown in the CNS due to lack of specific astroglial markers. In this study, molecular identity of in vivo astrocytes was characterized in BAC ALDH1L1 and BAC GLT1 eGFP promoter reporter transgenic mice. ALDH1L1 promoter is selectively activated in adult cortical and spinal cord astrocytes, indicated by the overlap of eGFP expression with ALDH1L1 and GFAP, but not with NeuN, APC, Olig2, IbaI, PDGFRα immunoreactivity in BAC ALDH1L1 eGFP reporter mice. Interestingly, ALDH1L1 expression levels (protein, mRNA, and promoter activity) in spinal cord were selectively decreased during postnatal maturation. In contrast, its expression was up-regulated in reactive astrocytes in both acute neural injury and chronic neurodegenerative (G93A mutant SOD1) conditions, similar to GFAP, but opposite of GLT1. ALDH1L1(+) and GLT1(+) cells isolated through fluorescence activated cell sorting (FACS) from BAC ALDH1L1 and BAC GLT1 eGFP mice share a highly similar gene expression profile, suggesting ALDH1L1 and GLT1 are co-expressed in the same population of astrocytes. This observation was further supported by overlap of the eGFP driven by the ALDH1L1 genomic promoter and the tdTomato driven by a 8.3kb EAAT2 promoter fragment in astrocytes of BAC ALDH1L1 eGFP X EAAT2-tdTomato mice. These studies support ALDH1L1 as a general CNS astroglial marker and investigated astrocyte heterogeneity in the CNS by comparing the molecular identity of the ALDH1L1(+) and GLT1(+) astrocytes from astroglial reporter mice. These astroglial reporter mice provide useful in vivo tools for the molecular analysis of astrocytes in physiological and pathological conditions.
Determination of Anthraquinone in Capacitor Dielectrics (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Anthraquinone in Capacitor DielectricsP. D. Garn and Mary C. BottCite this: Anal. Chem. 1961, 33, 1, 84–85Publication Date (Print):January 1, 1961Publication History Published online1 May 2002Published inissue 1 January 1961https://doi.org/10.1021/ac60169a024RIGHTS & PERMISSIONSArticle Views71Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (288 KB) Get e-Alerts Get e-Alerts
Influence of Piezoelectric Film and Electrode Materials on Film Bulk Acoustic-Wave Resonator Characteristics (2004)

This study adopts the one-dimensional Mason model and basic transmission line theory to investigate the influence of different piezoelectric films and electrode materials on the characteristics of a thin film bulk acoustic-wave resonator (FBAR). The influences of different electrodes, piezoelectric films, and supporting membrane thicknesses are also explored. The results confirm that the material properties and thickness of the piezoelectric film play a significant role in determining the performance of the FBAR, and influence such characteristics as the resonant frequency, the bandwidth, and the insertion loss. Therefore, the choice of piezoelectric material has a pronounced influence upon the subsequent design of the FBAR filter. Since the results also demonstrate that the resonant frequency of the FBAR is influenced by the thickness of each of the layers within the acoustic wave path, and by the resonance area, the potential exists to tune the characteristics of the FBAR by specifying appropriate geometric parameters during the FBAR design stage.
Ethylene–vinyl acetate semi‐batch emulsion copolymerization: Use of factorial experiments for improved process understanding (1993)

Abstract A good working knowledge of the mechanism and an appreciation of the effects the process variables have on the properties of interest are required for optimization and control of polymerization processes. Despite the importance of ethylene‐vinyl acetate emulsion copolymers, limited kinetic information is available. Results from a series of factorial experiments are presented here which examine the emulsion polymerization of ethylene with vinyl acetate. Copolymers of up to 32 wt % ethylene have been produced at an ethylene pressure of 500 psig and a temperature of 20°C. The effects of the process variables on the rate of polymerization, copolymer composition, particle size and number, molecular weight averages, and gel content are discussed. The kinetic results obtained suggest process improvements for the production of homogeneous copolymer. Mechanistically, the locus of polymerization has been verified as the polymer particles and little water phase polymerization was observed. © 1993 John Wiley & Sons, Inc.
Lattice Modification in Ion‐Implanted Ceramics (1984)

The effect of ion implantation on alumina (Al 2 O 3 ) and silicon carbide (SiC) was investigated by Rutherford backscattering (RBS), indentation hardness, fracture toughness, transmission electron microscopy (TEM), and linear scratching with a diamond stylus. The implanted (10 l6 to 10 17 Cr.cm −2 at 280 to300 keV, 1 to 4 |MX 10 l6 Ti.cm −2 at 150 keV,2 |MX 10 16 Zr.cm −2 at 150 keV) AI 2 O 3 lattice is significantly damaged but remains crystalline; the lattice hardness increases, and the scratched surface is less sensitive to fracture. The implanted (10 13 to 10 l6 N.cm −2 at 62 keV, 10 14 to 10 l6 Cr.cm −2 at 280 keV) Sic lattice becomes amorphous to a depth of 250 nm, becomes less hard, and deforms without fracture when scratched. The variation in Rutherford backscattered spectra and in surface hardness with annealing are reported and interpreted in terms of lattice defects for the Al 2 O 3 specimens.