gebhart/patrepeval huggingface dataset:
Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways (2005)

In the developing vertebrate retina, progenitor cells initially proliferate but begin to produce postmitotic neurons when neuronal differentiation occurs. However, the mechanism that determines whether retinal progenitor cells continue to proliferate or exit from the cell cycle and differentiate is largely unknown. Here, we report that histone deacetylase 1 (Hdac1) is required for the switch from proliferation to differentiation in the zebrafish retina. We isolated a zebrafish mutant, ascending and descending (add), in which retinal cells fail to differentiate into neurons and glial cells but instead continue to proliferate. The cloning of the add gene revealed that it encodes Hdac1. Furthermore, the ratio of the number of differentiating cells to that of proliferating cells increases in proportion to Hdac activity, suggesting that Hdac proteins regulate a crucial step of retinal neurogenesis in zebrafish. Canonical Wnt signaling promotes the proliferation of retinal cells in zebrafish, and Notch signaling inhibits neuronal differentiation through the activation of a neurogenic inhibitor, Hairy/Enhancer-of-split (Hes). We found that both the Wnt and Notch/Hes pathways are activated in the add mutant retina. The cell-cycle progression and the upregulation of Hes expression in the add mutant retina can be inhibited by the blockade of Wnt and Notch signaling, respectively. These data suggest that Hdac1 antagonizes these pathways to promote cell-cycle exit and the subsequent neurogenesis in zebrafish retina. Taken together, these data suggest that Hdac1 functions as a dual switch that suppresses both cell-cycle progression and inhibition of neurogenesis in the zebrafish retina.
Nature of polymorphism in HLA-A, -B, and -C molecules. (1988)

Diversity in 39 HLA-A, -B, and -C molecules is derived from 20 amino acid positions of high variability and 71 positions of low variability. Variation in the structurally homologous alpha 1 and alpha 2 domains is distinct and may correlate with partial segregation of peptide and T-cell receptor binding functions. Comparison of 15 HLA-A with 20 HLA-B molecules reveals considerable locus-specific character, due primarily to differences at polymorphic residues. The results indicate that genetic exchange between alleles of the same locus has been a more important mechanism in the generation of HLA-A, -B, and -C diversity than genetic exchange events between alleles of different loci.
진행 위암환자에서 위 운동기능과 위 윤상근내 c-kit 밀도간의 상관 관계 (1998)

Background/Aims : Gastric motor function in patients with advanced gastric cancer (AGC) may dependent upon the extent, depth of invasion, and/or location of cancer. The network of interstitial cell of Cajal (ICC) acts as a pacemaker cell to produce the slow wave, and tyrosine kinase receptor, c-kit plays an important role in development and function of the ICC. We investigated the gastric motor function in patients with advanced gastric cancer, and examined the density of c-kit+ cells in circular muscle layer of the stomach to investigate a possible correlation between gastric motor function and the density of c-kit. Methods . The subjects include 25 patients operated for non-obstructive AGC. Preoperative electrogastrography (EGG) and gastric emptying (GE) scan were performed in all patients. The frozen samples of circular muscle without cancer infiltration in midantrum and midbody, greater curvature were prepared from resected tissue and immunohistochemistry for c-kit was performed. The density of c-kit was quantitatively analyzed. Results: Several GE parameters including T1/2 were deranged in patients with AGC, especially antral lesion. There was no significant difference in GE parameters or frequency of slow wave between antrum and body in AGC. The density of c-kit in antrum was greater trend than that in body. No correlation was found among the density of c-kit, T1/2 and the slow wave frequency. Conclusions . We observed a delayed gastric emptying in patients with advanced gastric cancer, especially antral lesion without any abnormalities in myoelectrical activity. No correlation was found among T1/2, slow wave frequency and c-kit density in patients with advanced gastric cancer.
Developing a deeper insight into reproductive biomarkers (2017)

The development of biomarkers of reproductive medicine is still in its infancy because many black boxes are still present in reproductive medicine. Novel approaches to human infertility diagnostics and treatment must be developed because reproductive medicine has lagged behind in the implementation of biomarkers in clinical medicine. Despite the dearth of the available literature, the current rapid pace of publications suggests that this gap will soon be filled therefore; this review is a précis of the research that has been done so far and will provide a basis for the development of biomarkers in reproductive medicine.
Practical Monte Carlo sputter deposition simulation with quasi-axis-symmetrical (QAS) approximation (2002)

A practical Monte Carlo (MC) sputter deposition profile model has been developed to achieve accurate profile simulation within reasonable calculation time. The key features of the model are: (1) a quasi-axi-symmetrical (QAS) approximation which enables to convert 3D trajectories of incident atoms into 2D sputter deposition profiles in terms of the string model, and (2) calculation of the collision cross-section by means of Lennard-Jones potential. The simulated profiles of collimated-sputter titanium (Ti) in contact holes well agree with the experimental SEM profiles within 5% accuracy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Partial oxidation of isobutene over molybdenum trioxide (MoO3)-uranium trioxide (UO3)-silicon dioxide catalysts. A reaction network (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPartial oxidation of isobutene over molybdenum trioxide (MoO3)-uranium trioxide (UO3)-silicon dioxide catalysts. A reaction networkVicente Cortes Corberan, Avelino Corma, and Gojko KremenicCite this: Ind. Eng. Chem. Prod. Res. Dev. 1984, 23, 4, 546–552Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/i300016a007https://doi.org/10.1021/i300016a007research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Identification of a Meningococcal<scp>l</scp>-Glutamate ABC Transporter Operon Essential for Growth in Low-Sodium Environments (2006)

GdhR is a meningococcal transcriptional regulator that was previously shown to positively control the expression of gdhA, encoding the NADP-specific L-glutamate dehydrogenase (NADP-GDH), in response to the growth phase and/or to the carbon source. In this study we used reverse transcriptase-PCR-differential display (to identify additional GdhR-regulated genes. The results indicated that GdhR, in addition to NADP-GDH, controls the expression of a number of genes involved in glucose catabolism by the Entner-Doudoroff pathway and in l-glutamate import by an unknown ABC transport system. The genes encoding the putative periplasmic substrate-binding protein (NMB1963) and the permease (NMB1965) of the ABC transporter were genetically inactivated. Uptake experiments demonstrated an impairment of L-glutamate import in the NMB1965-defective mutant in the absence or in the presence of a low sodium ion concentration. In contrast, at a sodium ion concentration above 60 mM, the uptake defect disappeared, possibly because the activity of a sodium-driven secondary transporter became predominant. Indeed, the NMB1965-defective mutant was unable to grow at a low sodium ion concentration (<20 mM) in a chemically defined medium containing L-glutamate and four other amino acids that supported meningococcal growth, but it grew when the sodium ion concentration was raised to higher values (>60 mM). The same growth phenotype was observed in the NMB1963-defective mutant. Cell invasion and intracellular persistence assays and expression data during cell invasion provided evidence that the l-glutamate ABC transporter, tentatively named GltT, was critical for meningococcal adaptation in the low-sodium intracellular environment.
Electromagnetic Impact Welding of Al-to-Al–Li Sheets (2009)

The potential for weight savings resulting from the low density and high stiffness of aluminum-lithium (Al–Li) alloys and the difficulty in fusion welding of these alloys led to this study of solid state welding of Al–Li alloys for its potential application in the aerospace and automobile industries. The present study demonstrates the feasibility of electromagnetic (EM) welding of Al-to-Al–Li sheets by using Al drivers to drive the electrically poor conductive Al–Li sheets. A study has been carried out to characterize the electromagnetic impact welding of Al-to-Al–Li sheets of 1 mm thickness. Specific heat treatment cycle need to be followed prior to EM welding of Al–Li sheets. The results of the microstructure and tensile shear strength tests are reported.
Spectral Line Interferometry: a Proposed Means of Selectively Measuring the Change in the Density of a Specific Atomic Population (1970)

An extension of the two-wavelength interferogram technique is proposed that will enable selective measurements to be made of the variation in the density of a specific atomic population. One wavelength should be chosen to closely coincide with the wavelength associated with an absorption line of the species of interest, whereas the other wavelength should be displaced by several angstroms from the line. The difference between the fringe shifts on the two interferograms would then enable the density variation of the specific atomic population of interest to be measured with high sensitivity. Two criteria are established that ascertain for any system the minimum density that could be detected, and the range in density variation for which the interferograms should be discernible.
Neuroprotection by (R)-deprenyl and 7-nitroindazole in the MPTP C57BL/6 mouse model of neurotoxicity. (1999)

The neurodegenerative properties of the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are thought to result from inhibition of complex I of the mitochondrial respiratory chain by the monoamine oxidase-B (MAO-B) generated 1-methyl-4-phenylpyridinium metabolite MPP+. 7-Nitroindazole (7-NI) both a reversible MAO-B inhibitor and a neuronal nitric oxide synthase (nNOS) inhibitor, and (R)-deprenyl a potent MAO-B inactivator, provide neuroprotection in the C57BL/6 mouse model of MPTP neurotoxicity. The results reported here demonstrate the complexities of the effects of 7-NI in this model and examine the possibility of other mechanisms of neuroprotection by (R)-deprenyl.
An Evaluation of Plant Growth and Development under Various Daily Quantum Integrals (1991)

Plants of chrysanthemum [Dendranthema × grandiflorum (Ramat.) Kitamura], radish (Raphanus sativus L.), corn (Zea mays L.), and cucumber (Cucumis sativus L.) were grown under 8-, 12-, 18- or 24-hour daylengths and at three photosynthetic photon fluxes (PPF) within each daylength to evaluate growth and development responses to daily quantum integral (PPF × duration). For the same daily quantum integral, dry matter accumulation and leaf area development were less under 24-hour than under 18-hour daylengths with chrysanthemum and radish. With corn and cucumber, these values were similar under 12-, 18-, and 24-hour daylengths. In all of the species, leaf area and dry matter development were lowest under the 8-hour daylength. Continuous (24-hour) daylength produced some growth abnormalities in radish and chrysanthemum. Specific leaf weight in all species and flower node count in cucumber were linearly related to daily quantum integral up to the highest values examined (73.5 mol·day -1 ·m -2 ). All species showed expected photoperiod responses with respect to flowering, but the rate of floral development and number of flower buds formed were highest under the highest PPF (and highest daily quantum integral) treatments. The results indicate that field phenotypes can be obtained in controlled environment (CE) conditions, providing the field daylength and daily quantum integral conditions are reproduced.
Effect of LED phototherapy on blood lactate level in Taekwondo contest (2017)

The effect of LED phototherapy on blood lactate level in the muscle was studied. A 450cm<sup>2</sup> large red and near infrared LED pad with its irradiance of 10mW/cm<sup>2</sup> was applied for 10 minutes to brachial muscle and quadriceps muscle of thigh to the participants before and after the Taekwondo contest. Blood samples from the participants were taken at 5 minutes after the competition and 10 minutes after the recovery. The test results showed that the LED therapy (LEDT) before and after the competition had a significant effect on the decrease of blood lactate level of the participants.
Novel colour selection scheme for 2D barcode (2009)

The use of colours in 2D barcodes is challenging. This is even more so in barcodes for mobile devices. Although 2D barcodes are fast becoming the ubiquitous tool for mobile computing, most implementations considered monochromatic 2D barcodes. A few colour 2D barcodes are emerging but these implementations only utilises a limited number of colours. In this paper, we present the challenges faced by the use of colours in 2D barcodes for mobile devices. We also introduce a novel colour selection scheme for 2D barcode, which is implemented in our novel colour 2D barcode - the MMCCTM. Our novel selection scheme resulted in a robust 2D barcode that can use more colours than existing colour 2D barcodes for mobile devices.
Timing of larval release by two Caribbean demosponges (1997)

MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsTheme Sections MEPS 155:309-313 (1997) - doi:10.3354/meps155309 Timing of larval release by two Caribbean demosponges Lindquist N, Bolser R, Laing K The timing of larval release has important implications for a larva's potential vulnerability to predators and environmental stresses. For larvae with planktonic periods of only minutes to hours, timing of larval release also determines the light levels that larvae experience, which can strongly influence their settlement behavior. We placed larval traps over colonies of 2 common Caribbean sponges and found that both species released larvae during daylight hours. Niphatesdigitalis generally releases its larvae between 07:00 and 11:00 h, while Callyspongiavaginalis releases its larvae later in the day. Of 17 captured N. digitalis larvae released 0.5 to 1 m above the substrate, 13 remained near the bottom, and 8 of these 13 contacted the substrate within 10 min. For short-lived larvae, daytime release and their photonegative behavior at settlement should drive them to settle in shaded microhabitats that protect juveniles from predators and solar UV radiation. Larvae of N. digitalis and C. vaginalis are distasteful to potential predators; thus they can remain near the bottom with fishes and yet not be consumed. These data support a general co-occurrence of daytime spawning of conspicuous, short-lived larvae and larval distastefulness that previously had been noted only for tropical ascidians. Sponges · Larvae · Timing of larval release · Larval dispersal · Larval palatability Full text in pdf format PreviousExport citation RSS - Facebook - Tweet - linkedIn Cited by Published in MEPS Vol. 155. Publication date: August 28, 1997 Print ISSN:0171-8630; Online ISSN:1616-1599 Copyright © 1997 Inter-Research.
Effect of Background Gas on Laser-Induced Electron Emission from Metal Surfaces (1965)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation N. R. Isenor; Effect of Background Gas on Laser‐Induced Electron Emission from Metal Surfaces. J. Appl. Phys. 1 January 1965; 36 (1): 316–317. https://doi.org/10.1063/1.1713899 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioJournal of Applied Physics Search Advanced Search |Citation Search
Immersive vehicle simulators for prototyping, training and ergonomics (2004)

In most vehicle simulators, complete physical mockups equipped with steering wheel, gearshift and pedals are required. These devices are essential in trying to simulate real conditions, but as a drawback the system becomes expensive, huge (non mobile), and limited to reflect changes on the vehicle type, dimensions, or interior design. We have implemented different configurations for an immersive vehicle simulator, ranging from the use of a real mockup equipped with force-feedback steering wheel, gearshift and pedals, to fully virtual control metaphors, which are based only on trackers and datagloves. We propose such fully virtual control metaphors as an alternative to minimize the use of physical devices in simulators.
Catalytic Activity of Partially Oxidized Transition-metal Carbide–Nitride for Oxygen Reduction Reaction in Sulfuric Acid (2008)

Abstract In order to commercialize polymer electrolyte fuel cells (PEFCs) widely, partially oxidized transition-metal carbide–nitride (TM-C–N; TM = Ti, Zr, and Ta) have been investigated as new cathodes without platinum. The specimens were prepared by the electrophoretic deposition of the transition-metal carbide–nitride on titanium plate and were heat-treated at 1000 °C under flowing 2%-H2/N2 gas containing ca. 0.25% oxygen. Partially oxidized Ta-based catalysts had highest catalytic activity, followed by Ti- and Zr-based catalysts.
상호교류분석이론에 기초한 부모교육이 어머니의 자아개념과 대인관계 능력에 미치는 영향 (2010)

본 연구는 교류분석이론에 근거한 부모교육 프로그램이 유아기 자녀를 둔 어머니의 자아개념과 대인관계 능력에 미치는 영향을 살펴보는데 연구의 목적이 있다. 이를 위해 서울에 위치한 어린이집에 다니는 학부모를 대상으로 부모교육신청서를 받은 뒤, 임의로 실험집단 20명과 통제집단 20명으로 나누어 자아개념과 대인관계능력에 대한 사전검사를 실시하고 동질성을 확인하였다. 사전검사 후, 실험집단에는 8주에 걸친 교류분석이론에 근거한 부모교육을 실시하고, 통제집단에는 전형적인 내용의 부모교육을 가정통신문을 통해 실시하였다. 실험처치가 끝난 후, 동일한 검사지로 사후검사를 실시하였으며, 수집한 자료는 Spss 12.0 프로그램을 활용하여 t-검증을 통하여 실험처치의 효과를 비교·분석하였다. 사후검사 결과 두 집단 간의 유의미한 차이가 발견되어 교류분석이론에 근거한 부모교육이 유아기 자녀를 둔 어머니의 긍정적 자아개념과 대인관계능력을 형성하는데 도움이 되는 것으로 나타났다.
Binding of taxol to human plasma, albumin and alpha 1-acid glycoprotein. (1993)

The binding of taxol to human plasma and to individual plasma proteins was studied by equilibrium dialysis. Taxol was found to bind extensively (about 95%) without a significant difference between healthy volunteers and cancer patients. At clinically relevant concentrations (0.1-6 microM), the binding was found to be concentration independent, indicating nonspecific hydrophobic binding. Human serum albumin and alpha 1-acid glycoprotein were found to contribute about equally to the binding, with a minor contribution from lipoproteins. None of the drugs commonly coadministered with taxol (dexamethasone, diphenhydramine, ranitidine, doxorubicin, 5-fluorouracil and cisplatin) altered the binding of taxol significantly. The protein binding of taxol was found to dramatically decrease the red blood cell uptake of taxol.
Acid suppression and gastri atrophy: sifting fact from fiction (1998)

Prolonged pharmacological acid suppression is associated with various histological changes in the gastric mucosa, particularly in Helicobacter pylori infected patients. In a number of subjects these changes include a shift in the gastric inflammation from the antrum to the corpus. This finding has been interpreted as gastric atrophy, and the possibility that acid suppression accelerates the progress of lesions that may lead to gastric cancer has been considered. Two recent studies on the relation between treatment with proton pump inhibitors and atrophic gastritis have yielded apparently contradictory results. These studies are reviewed in detail here and some of the possible reasons for the discrepant conclusions are explored. In particular, the way the terms "gastric atrophy" and "atrophic gastritis" are used is examined critically.
Iron metabolism and HIV infection: reciprocal interactions with potentially harmful consequences? (1999)

Humans with advanced human immunodeficiency virus (HIV) infection present some evidence suggestive of iron accumulation. Ferritin concentrations increase with HIV disease progression, and iron accumulates in several tissues. Iron excess may exert negative effects in individuals with HIV. Indeed, iron accumulation seems to be associated with shorter survival, and a number of investigations point to an iron-mediated oxidative stress in subjects with HIV infection. The observations on humans infected with HIV are in part supported by in-vitro findings. Indeed, in-vitro HIV infection is associated with changes in iron metabolism, and an iron-mediated oxidative stress is likely to contribute to viral cytopathogenicity. Furthermore, it is interesting to point out that the interaction between iron and HIV may be reciprocal, since viruses with a life-cycle involving a DNA phase require chelatable iron for optimum replication. This combined evidence suggests that iron metabolism is an important area for virus/host interaction. These observations may be relevant to both laboratory monitoring and clinical treatment of individuals with HIV.
Polyamines and apoptosis (2005)

The natural polyamines putrescine, spermidine and spermine are in multiple ways involved in cell growth and the maintenance of cell viability. In the course of the last 15 years more and more evidence hinted also at roles in gene regulation. It is therefore not surprising that the polyamines are involved in events inherent to genetically programmed cell death. Following inhibition of ornithine decarboxylase, a key step in polyamine biosynthesis, numerous links have been identified between the polyamines and apoptotic pathways. Examples of activation and prevention of apoptosis due to polyamine depletion are known for several cell lines. Elevation of polyamine concentrations may lead to apoptosis or to malignant transformation. These observations are discussed in the present review, together with possible mechanisms of action of the polyamines. Contradictory results and incomplete information blur the picture and complicate interpretation. Since, however, much interest is focussed at present on all aspects of programmed cell death, a considerable progress in the elucidation of polyamine functions in apoptotic signalling pathways is expected, even though enormous difficulties oppose pinpointing specific interactions of the polyamines with pro- and anti-apoptotic factors. Such situation is quite common in polyamine research.