gebhart/patrepeval huggingface dataset:
The Transcription Factor ARID3a Is Important for In Vitro Differentiation of Human Hematopoietic Progenitors (2015)

We recently reported that the transcription factor ARID3a is expressed in a subset of human hematopoietic progenitor stem cells in both healthy individuals and in patients with systemic lupus erythematosus. Numbers of ARID3a(+) lupus hematopoietic stem progenitor cells were associated with increased production of autoreactive Abs when those cells were introduced into humanized mouse models. Although ARID3a/Bright knockout mice died in utero, they exhibited decreased numbers of hematopoietic stem cells and erythrocytes, indicating that ARID3a is functionally important for hematopoiesis in mice. To explore the requirement for ARID3a for normal human hematopoiesis, hematopoietic stem cell progenitors from human cord blood were subjected to both inhibition and overexpression of ARID3a in vitro. Inhibition of ARID3a resulted in decreased B lineage cell production accompanied by increases in cells with myeloid lineage markers. Overexpression of ARID3a inhibited both myeloid and erythroid differentiation. Additionally, inhibition of ARID3a in hematopoietic stem cells resulted in altered expression of transcription factors associated with hematopoietic lineage decisions. These results suggest that appropriate regulation of ARID3a is critical for normal development of both myeloid and B lineage pathways.
The synthesis of robust, polymeric hole-transport materials from oligoarylamine substituted styrenes (2007)

Novel styrene-based oligoarylamine monomers are described which are suitable for the preparation of polymeric hole-transport materials, with very high glass transition temperatures. The monomers are prepared using the Wittig reaction from the appropriate aldehyde precursor, which was assembled using the classical Ullmann reaction. A number of the monomers yielded high-quality crystals which facilitated X-ray characterisation. Polymerisation was achieved either by solution free-radical initiation or by condensed phase thermal autopolymerisation. The latter suggests a method of initiator-free polymerisation which may have potential for multilayer device fabrication.
Yeast vectors for integration at the HO locus (2001)

We have constructed new yeast vectors for targeted integration of desired sequences at the Saccharomyces cerevisiae HO locus. Insertion at HO has been shown to have no effect on yeast growth, and thus these integrations should be neutral. One vector contains the KanMX selectable marker, and integrants can be selected by resistance to G418. The other vector contains the hisG-URA3-hisG cassette, and integrants can be selected by uracil prototrophy. Subsequent growth on 5-FOA permits identification of colonies where recombination between the hisG tandem repeats has led to loss of the URA3 marker and return to uracil auxotrophy. We also describe several new bacterial polylinker vectors derived from pUC21 (ampicillin resistance) and pUK21 (kanamycin resistance).
Dynamic State Warping (2017)

The ubiquity of sequences in many domains enhances significant recent interest in sequence learning, for which a basic problem is how to measure the distance between sequences. Dynamic time warping (DTW) aligns two sequences by nonlinear local warping and returns a distance value. DTW shows superior ability in many applications, e.g. video, image, etc. However, in DTW, two points are paired essentially based on point-to-point Euclidean distance (ED) without considering the autocorrelation of sequences. Thus, points with different semantic meanings, e.g. peaks and valleys, may be matched providing their coordinate values are similar. As a result, DTW is sensitive to noise and poorly interpretable. This paper proposes an efficient and flexible sequence alignment algorithm, dynamic state warping (DSW). DSW converts each time point into a latent state, which endows point-wise autocorrelation information. Alignment is performed by using the state sequences. Thus DSW is able to yield alignment that is semantically more interpretable than that of DTW. Using one nearest neighbor classifier, DSW shows significant improvement on classification accuracy in comparison to ED (70/85 wins) and DTW (74/85 wins). We also empirically demonstrate that DSW is more robust and scales better to long sequences than ED and DTW.
Pharmacokinetics and acceptability of once- versus twice-daily lamivudine and abacavir in HIV type-1-infected Ugandan children in the ARROW Trial (2010)

In children aged 3-12 years, AUC(0-24) of lamivudine and abacavir were bioequivalent on once- and twice-daily regimens. Once-daily dosing of abacavir and lamivudine could provide an alternative dosing strategy for HIV-1-infected children, with high acceptability and strong preference suggesting the potential for improved adherence.
Performance study of inductive output cryotronic converters (1979)

A matrix method of electric circuit analysis was used for the theoretical performance study of a converter based on both a fullwave rectifier and a cyclic superconducting transformer with two cryotrons. The solution for the loop current matrix allows to calculate the transient commutation process in any cryotronic converter under any shape of supply voltage. Expressions are given for the converter maximum current under load conditions. The experimental study of the commutation processes was conducted on the model of a cyclic-superconducting-transformer-based cryotronic converter at the working current of 800 A in the secondary coil ratio of the primary and secondary 800:1, of the superconducting transformer without a ferromagnetic core. In the cylindrical cryotrons the switching element is made of a bifilaly wound Pb-3.8% Sb tape and is placed between the control winding and the superconducting shield. In resistive state the valve resistance is 5.5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> Ω at 4.2 K. A superconducting solenoid consisting of four disk coils connected in parallel served as the converter load, its inductance being 0.15 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> H. The measurements of currents in the secondary circuits and voltage drops on the cryotron valves were made by Hall probes and potential probes, respectively. The commutation processes were studied in conditions of pumping the current into inductive load and energy recuperation accumulated in the load through the superconducting transformer into its primary. The paper offers current oscillograms for the windings of control and voltage drops on the valves of both cryotrons, and also oscillograms for the transformer's primary and secondary and the load.
Homoleptic yttrium and lanthanide complexes of aminotroponiminates and aminotroponates: experimental and theoretical studies (1998)

Density functional theory (DFT) calculations were performed for the homoleptic aminotroponiminate complexes [Ln{C7H5(NPri)2}3] (Ln = Y or Sm) in order to get structural and energetic information about the possible isomers. The calculations predict a propeller-shaped chiral isomer of D3 symmetry as lowest in energy. Two less stable isomers turned out to be stationary points of higher order. One is likely to be close to a structure acting as intermediate in the mechanism of rapid racemisation observed by NMR studies. Based on these results experimental and DFT computational studies of homoleptic lanthanide complexes with the new ligand system aminotroponate C7H5(NPri)O– were carried out. This related but asymmetric ligand results in a slower isomerisation and thus detection of the concerned species: 1H NMR experiments showed an equilibrium of several [Y{C7H5(NPri)O}3] isomers in solution, in agreement with the computational results.
The combination of palm print and hand geometry for biometrics palm recognition (2012)

Biometrics as a method for identification systems has been widely used for its robustness; one of its used is based on human palm. Palm has unique characteristics to be used in personal identification because of it features, nam ely palm print and hand geometry. This paper studied about biometrics of palm for identification system using the physical form o f human hands, represented by the image of the palm. The methodology for palm recognition consisted of block-based line detection which dealing with palm print feature extraction process, and cha in code which solved the hand geometric feature extraction. We combined those two respective features and recognized it using Dynamic Time Warping (DTW) method which was able to measure the distance between two different features. The result can be u sed for personal identification in authentication systems f or information security.
Zika Virus as Oncolytic Therapy for Brain Cancer: Myth or Reality? (2019)

The ability of self-replicating oncolytic viruses (OVs) to preferentially infect and lyse cancer cells while stimulating anti-tumor immunity of the host strongly indicates its value as a new field of cancer therapeutics to be further explored. The emergence of Zika virus (ZIKV) as a global health threat due to its recent outbreak in Brazil has caught the attention of the scientific community and led to the discovery of its oncolytic potential for the treatment of glioblastoma multiforme (GBM), the most common and fatal brain tumor with poor prognosis. Herein, we evaluate the neurotropism of ZIKV relative to the receptor tyrosine kinase AXL and its ligand Gas6 in viral entry and the RNA-binding protein Musashi-1 (MSI1) in replication which are also overexpressed in GBM, suggesting its potential for specific targeting of the tumor. Additionally, this review discusses genetic modifications performed to enhance safety and efficacy of ZIKV as well as speculates future directions for the OV therapy.
Neutrophils Promote Mononuclear Cell Infiltration During Viral-Induced Encephalitis (2003)

Neutrophils are the first infiltrating cell population to appear within the CNS during infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV). To determine whether neutrophils play a role in limiting acute JHMV infection, mice were depleted of neutrophils. Infection of neutropenic animals resulted in increased levels of virus replication and mortality compared with control mice. Furthermore, neutropenia resulted in significantly reduced mononuclear leukocyte infiltration possibly due to reduced loss of blood brain barrier integrity during acute JHMV infection. These data suggest that infiltrating neutrophils are crucial for limiting virus replication during acute JHMV infection, contribute to the loss of blood brain barrier integrity and play a role in shaping adaptive immunity within the CNS.
Distinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer (2017)

Colorectal cancer (CRC) is a heterogeneous disease and recent advances in subtype classification have successfully stratified the disease using molecular profiling. The contribution of bacterial species to CRC development is increasingly acknowledged, and here, we sought to analyse CRC microbiomes and relate them to tumour consensus molecular subtypes (CMS), in order to better understand the relationship between bacterial species and the molecular mechanisms associated with CRC subtypes. We classified 34 tumours into CRC subtypes using RNA-sequencing derived gene expression and determined relative abundances of bacterial taxonomic groups using 16S rRNA amplicon metabarcoding. 16S rRNA analysis showed enrichment of Fusobacteria and Bacteroidetes, and decreased levels of Firmicutes and Proteobacteria in CMS1. A more detailed analysis of bacterial taxa using non-human RNA-sequencing reads uncovered distinct bacterial communities associated with each molecular subtype. The most highly enriched species associated with CMS1 included Fusobacterium hwasookii and Porphyromonas gingivalis. CMS2 was enriched for Selenomas and Prevotella species, while CMS3 had few significant associations. Targeted quantitative PCR validated these findings and also showed an enrichment of Fusobacterium nucleatum, Parvimonas micra and Peptostreptococcus stomatis in CMS1. In this study, we have successfully associated individual bacterial species to CRC subtypes for the first time.
Efficient, metamaterial-inspired loop-monopole antenna with shaped radiation pattern (2012)

A new family of metamaterial-inspired monopole antennas is reported. Split-ring resonator (SRR) is introduced into the near field region of a monopole antenna. Four configurations are proposed by changing the position of the slot of the SRR. In each case, we obtain a new behavior and a new resonance frequency, in addition to that of the monopole. The results are presented for the return loss, efficiency, surface current and radiation pattern. Four prototypes are fabricated and measured. Good agreement between numerical and experimental results is demonstrated.
Polycyclic aromatic compounds in coal-derived products: Relation between structure and abundance (1986)

A number of coal liquids, coal tars, and coal extracts were separated into chemical classes and characterized by capillary column gas chromatography. Selective stationary phases including a newly synthesized biphenyl polysiloxane and a liquid crystalline polysiloxane were used to resolve these complex mixtures into specific compounds for identification and quantitation. The chemical classes characterized included the polycyclic aromatic hydrocarbons (PAH), sulfur heterocycles (PASH), nitrogen heterocycles (PANH), amino-substituted polycyclic aromatic compounds (PAC), and hydroxy-substituted PAC. Furthermore, compounds containing two heteroatoms were also characterized. Nitrogen- and sulfur-selective detectors, as well as mass spectrometry, were used to confirm identifications. It was found that preferred aromatic structures and positions of substitution were common to all of the chemical classes. This evidence is useful in predicting the chemical compositions of coal-derived materials and, ultimately, the structure of coal.
Adverse drug reaction of the month--a new series (1997)

This issue of the Postgraduate Medical Journal sees the launch of a new series of articles, Adverse drug reaction of the month. The series has two objectives. First, it is intended to inform practising clinicians about significant adverse reac- tions (ADRs), as well as their diagnosis, management and prevention. Second, we unashamedly wish to use it to promote the Committee on Safety of Medicines/Medicine Control Agency (CSM/MCA) 'yellow card' scheme.
Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling (2016)

Amino acid availability activates signaling by the mammalian target of rapamycin (mTOR) complex 1, mTORC1, a master regulator of cell growth. The class III PI-3-kinase Vps34 mediates amino acid signaling to mTORC1 by regulating lysosomal translocation and activation of the phospholipase PLD1. Here, we identify leucyl-tRNA synthetase (LRS) as a leucine sensor for the activation of Vps34-PLD1 upstream of mTORC1. LRS is necessary for amino acid-induced Vps34 activation, cellular PI(3)P level increase, PLD1 activation, and PLD1 lysosomal translocation. Leucine binding, but not tRNA charging activity of LRS, is required for this regulation. Moreover, LRS physically interacts with Vps34 in amino acid-stimulatable non-autophagic complexes. Finally, purified LRS protein activates Vps34 kinase in vitro in a leucine-dependent manner. Collectively, our findings provide compelling evidence for a direct role of LRS in amino acid activation of Vps34 via a non-canonical mechanism and fill a gap in the amino acid-sensing mTORC1 signaling network.
Methyl Propyl Carbonate: A Promising Single Solvent for Li‐Ion Battery Electrolytes (1997)

Methyl propyl carbonate (MPC) solutions containing Li salts can be used as a single‐solvent electrolyte without addition of ethylene carbonate (EC). Graphite electrodes can be cycled at high reversible capacity in MPC solutions containing and . The use of acyclic, unsymmetric alkyl carbonate solvents, such as ethyl methyl carbonate (EMC) and MPC in Li‐ion based electrolytes, increases the stability of the graphite electrode. Whereas a small amount of EC is still needed as cosolvent in EMC solutions to obtain stable surface films on graphite electrodes, we show here that the surface films produced on graphite in MPC solutions (without added EC) are highly stable, allowing reversible Li‐ion intercalation. To understand this trend, we investigated the surface chemistry developed on lithium and carbon electrodes in MPC solutions in conjugation with electrochemical studies.
Displacing and Disrupting: A Dialogue on Hmong Studies and Asian American Studies (2015)

This article summarizes a roundtable discussion of scholars that took place at the Association for Asian American Studies Conference in San Francisco, 2014.Hailing from various academic disciplines, the participants explored the relationship between the emerging field of Hmong/Hmong American Studies and Asian American Studies.Questions of interest included:In what ways has Asian American Studies informed Hmong/Hmong American Studies, or failed to do so?In what ways does Hmong/Hmong American Studies enrich/challenge Asian American Studies?What are the tensions between these two fields and other related fields?How do/should the new programs in Hmong/Hmong American Studies relate to the existing Asian American Studies programs regarding curriculum, activism and/or resource allocation?
White Blood Cell Image Segmentation Using On-line Trained Neural Network (2005)

This paper addresses a fast white blood cell (WBC) image segmentation scheme implemented by on-line trained neural network. A pre-selecting technique, based on mean shift algorithm and uniform sampling, is utilized as an initialization tool to largely reduce the training set while preserving the most valuable distribution information. Furthermore, Particle Swarm Optimization (PSO) is adopted to train the network for a faster convergence and escaping from a local optimum. Experiment results show that under the compatible image segmentation accuracy, the training set and running time can be reduced significantly, compared with traditional training methods.
Material-Aware Mesh Deformations. (2006)

Most real world objects consist of non-uniform materials; as a result, during deformation the bending and shearing are distributed non-uniformly and depend on the local stiffness of the material. In the virtual environment there are three prevalent approaches to model deformation: purely geometric, physically driven, and skeleton based. This paper proposes a new approach to model deformation that incorporates non-uniform materials into the geometric deformation framework. Our approach provides a simple and intuitive method to control the distribution of the bending and shearing throughout the model according to the local material stiffness. Thus, we are able to generate realistic looking, material-aware deformations at interactive rates. Our method works on all types of models, including models with continuous stiffness gradation and non-articulated models such as cloth. The material stiffness across the surface can be specified by the user with an intuitive paint-like interface or it can be learned from a sequence of sample deformations.
The Role of the 3′ Untranslated Region in mRNA Sorting to the Vicinity of Mitochondria Is Conserved from Yeast to Human Cells (2003)

We recently demonstrated, using yeast DNA microarrays, that mRNAs of polysomes that coisolate with mitochondria code for a subset of mitochondrial proteins. The majority of these mRNAs encode proteins of prokaryotic origin. Herein, we show that a similar association occurs between polysomes and mitochondria in human cells. To determine whether mRNA transport machinery is conserved from yeast to human cells, we examined the subcellular localization of human OXA1 mRNA in yeast. Oxa1p is a key component in the biogenesis of mitochondrial inner membrane and is conserved from bacteria to eukaryotic organelles. The expression of human OXA1 cDNA partially restores the respiratory capacity of yeast oxa1- cells. In this study, we demonstrate that 1) OXA1 mRNAs are remarkably enriched in mitochondrion-bound polysomes purified from yeast and human cells; 2) the presence of the human OXA1 3' untranslated region (UTR) is required for the function of the human Oxa1p inside yeast mitochondria; and 3) the accurate sorting of the human OXA1 mRNA to the vicinity of yeast mitochondria is due to the recognition by yeast proteins of the human 3' UTR. Therefore, it seems that the recognition mechanism of OXA1 3' UTR is conserved throughout evolution and is necessary for Oxa1p function.
Double Point Contact in the k=3 Read-Rezayi State (2007)

We compute the dependence of the tunneling current in a double point contact in the k=3 Read-Rezayi state (which is conjectured to describe an incompressible quantum hall fluid at filling fraction nu=12/5) on voltage, separation between the two contacts, and temperature. Using the tunneling hamiltonian of cond-mat/0607431, we show that the effect of quasiholes in the bulk region between the two contacts is simply an overall constant multiplying the interference term. This is the same effect as found for the differential conductivity in cond-mat/0601242; the difference is that we do an actual edge theory calculation and compute the full current-voltage curve at weak tunneling.
Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice (2017)

Excessive production of inflammatory chemokines can cause chronic inflammation and thus impair cutaneous wound healing. Capturing chemokine signals using wound dressing materials may offer powerful new treatment modalities for chronic wounds. Here, a modular hydrogel based on end-functionalized star-shaped polyethylene glycol (starPEG) and derivatives of the glycosaminoglycan (GAG) heparin was customized for maximal chemokine sequestration. The material is shown to effectively scavenge the inflammatory chemokines MCP-1 (monocyte chemoattractant protein-1), IL-8 (interleukin-8), and MIP-1α (macrophage inflammatory protein-1α) and MIP-1β (macrophage inflammatory protein-1β) in wound fluids from patients suffering from chronic venous leg ulcers and to reduce the migratory activity of human monocytes and polymorphonuclear neutrophils. In an in vivo model of delayed wound healing (db/db mice), starPEG-GAG hydrogels outperformed the standard-of-care product Promogran with respect to reduction of inflammation, as well as increased granulation tissue formation, vascularization, and wound closure.
Geometric representation of the tree-search detector (2003)

Fixed-delay tree search with decision feedback (FDTS/DF) has been proposed for retrieving data from hard disk drives. One problem with the algorithm as originally posed is the large number of serial operations that must be performed during one clock cycle. The authors explore the decision space in FDTS/DF using linear discriminants, which leads to a geometric depiction of the decision space. For channels with a d=0 minimum runlength constraint the number of serial computations reduces to one multiplication and one addition. More importantly, though, on high density channels with a d=1 minimum runlength constraint, the detector can be implemented as a multilevel decision feedback equalizer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>