gebhart/patrepeval huggingface dataset:
Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia (1977)

Ninety-six patients with stage III and stage IV chronic lymphocytic leukemia (CLL) were randomized into one of three treatment schedules. Prednisone was common to all three schedules and was given daily in an initial dosage of 0.8 mg/kg for the first 14 days, with successive halving of the daily dose on days 15 and 29 for a total 6-wk course. Prednisone was then given once a month at 0.8 mg/kg once a day for each of 7 consecutive days. Schedule I was prednisone plus chlorambucil (CLB) given as a once-a-month dose of 0.4–0.8 mg/kg; schedule II was both drugs, but the CLB was given as a daily dose of 0.08 mg/kg; schedule III was prednisone alone. Complete and partial remission (CR + PR) was 47% for schedule I, 38% for schedule II, and 11% for schedule III. Patients who responded (CR + PR) in each of the treatment schedules survived longer than the nonresponders. Complete remission was obtained in both CLB treatment schedules, but not with the prednisone alone regimen. Although overall survival was best in the intermittent CLB arm, there was no significant difference in survival time between the three treatment schedules. Toxicity was minimal in all three regimens. Augmentation of the intermittent monthly CLB, even to 1.5 and 2.0 mg/kg, was tolerated without undue marrow toxicity. About 22% of these patients either had diabetes mellitus at the time of entry on the study or manifested hyperglycemia during the course of treatment and observation.
Efficient reverse-play algorithms for MPEG video with VCR support (2005)

Reverse playback is the most common video cassette recording (VCR) function in digital video players and it involves playing video frames in reverse order. However, the predictive processing techniques employed in MPEG severely complicate the reverse-play operation. For displaying single frame during reverse playback, all frames from the previous I-frame to the requested frame must be sent by the server and decoded by the client machine. It requires much higher bandwidth of the network and complexity of the decoder. In this paper, we propose a compressed-domain approach for an efficient implementation of the MPEG video streaming system to provide reverse playback over a network with the minimal requirements on the network bandwidth and the decoder complexity. In the proposed video streaming server, it classifies macroblocks in the requested frame into two categories-backward macroblocks (BMBs) and forward macroblock (FMBs). Two novel MB-based techniques are used to manipulate the necessary MBs in the compressed domain and the server then sends the processed MBs to the client machine. For BMBs, we propose a sign inversion technique, which is operated in the variable length coding (VLC) domain, to reduce the number of MBs that need to be decoded by the decoder and the number of bits that need to be sent over the network in the reverse-play operation. The server also identifies the previous related MBs of FMBs and those related maroblocks coded without motion compensation are then processed by a technique of direction addition of discrete cosine transform (DCT) coefficients to further reduce the computational complexity of the client decoder. With the sign inversion and direct addition of DCT coefficients, the proposed architecture only manipulates MBs either on the VLC domain or DCT domain to achieve the server with low complexity. Experimental results show that, as compared to the conventional system, the new streaming system reduces the required network bandwidth and the decoder complexity significantly.
The Recycling Endosome Protein Rab17 Regulates Melanocytic Filopodia Formation and Melanosome Trafficking (2011)

Rab GTPases including Rab27a, Rab38 and Rab32 function in melanosome maturation or trafficking in melanocytes. A screen to identify additional Rabs involved in these processes revealed the localization of GFP-Rab17 on recycling endosomes (REs) and melanosomes in melanocytic cells. Rab17 mRNA expression is regulated by microphthalmia transcription factor (MITF), a characteristic of known pigmentation genes. Rab17 siRNA knockdown in melanoma cells quantitatively increased melanosome concentration at the cell periphery. Rab17 knockdown did not inhibit melanosome maturation nor movement, but it caused accumulation of melanin inside cells. Double knockdown of Rab17 and Rab27a indicated that Rab17 acts on melanosomes downstream of Rab27a. Filopodia are known to play a role in melanosome transfer, and in Rab17 knockdown cells filopodia formation was inhibited. Furthermore, we show that stimulation of melanoma cells with α-melanocyte-stimulating hormone induces filopodia formation, supporting a role for filopodia in melanosome release. Cell stimulation also caused redistribution of REs to the periphery, and knockdown of additional RE-associated Rabs 11a and 11b produced a similar accumulation of melanosomes and melanin to that seen after loss of Rab17. Our findings reveal new functions for RE and Rab17 in pigmentation through a distal step in the process of melanosome release via filopodia.
Hydrogen/liquid vapor radio frequency glow discharge plasma oxidation/hydrolysis of expanded poly(tetrafluoroethylene) (ePTFE) and poly(vinylidene fluoride) (PVDF) surfaces (1991)

Abstract Modification of fluorine‐containing polymers has recently received much attention due to new chemistries allowing for refunctionalization of these materials, especially their surfaces. In this article results are discussed which demonstrate various interesting modifications (including incorporations of OH and oxygen comprised functionality) to expanded poly(tetrafluoroethylene) (ePTFE) surfaces. This is effected through the use of low damage, radio frequency glow discharge (RFGD) processes. The low damage conditions, which preserve the original pore structure/morphology of these RFGD treated materials, are supported by Scanning Electron Microscopy (SEM) while the resulting atomic and molecular effects are investigated through other surface analytical methodology. All materials reported in this investigation have been subjected to intensive structural analyses utilizing Electron Spectroscopy for Chemical Analysis (ESCA), Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR–FTIR), and wettability profiles obtained through contact angle measurements using a large series of liquids having varying surface tensions and surface reactive functionality. Through this multitechnique analysis of both expanded PTFE and poly(vinylidene fluoride) (PVDF) treated surfaces, a model is supported which illustrates surfaces possessing both high and low energy regions comprising both oxygen and fluorine functionality in close molecular proximity.
Effect of the water injection pressure on coal permeability based on the pore‐fracture fractal characteristics: An experimental study (2021)

Abstract Coal seam water injection is a commonly used method by which to improve coal seam permeability. To reveal how this method can enhance coal permeability from the perspective of the pore‐fracture structure, the permeability and porosity of raw coal samples under different water injection pressures were tested. Low‐temperature nitrogen adsorption (N 2 GA) and high‐pressure mercury intrusion porosimetry (MIP) were employed to characterize the changes in the pore‐fracture structures of water‐injected coal samples. Moreover, the relationship between the fractal dimension and coal permeability was studied using fractal theory. The results revealed the following. The internal pore‐fracture structures of the coal samples were rich in variety, and the pore span was large. With the increase of the water injection pressure, the volume ratios of macropores and mesopores gradually increased. Moreover, in the test interval, the fractal dimension of the water‐injected samples did not fluctuate substantially. With the increase of the water injection pressure, the integral dimension of seepage pores became positively correlated with permeability, while the fractal dimension of diffusion pores became negatively correlated with permeability. The results indicate that the increase in the water injection pressure not only increases the proportion of seepage pores, but also densifies the diffusion pores. Thus, the uniformity of diffusion pores can well reflect the permeability level of coal samples. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd.
Resonant excitation of Er3+ by the energy transfer from Si nanocrystals (2001)

Photoluminescence (PL) properties of SiO2 films containing Si nanocrystals (nc-Si) and Er were studied. The average size of nc-Si was changed in a wide range in order to tune the exciton energy of nc-Si to the energy separations between the discrete electronic states of Er3+. PL from exciton recombination in nc-Si and the intra-4f shell transition of Er3+ were observed simultaneously. At low temperatures, periodic features were observed in the PL spectrum of nc-Si. The period agreed well with the optical phonon energy of Si. The appearance of the phonon structure implies that nc-Si which satisfy the energy conservation rule during the energy transfer process can resonantly excite Er3+. For the PL from Er3+, a delay was observed after the pulsed excitation of nc-Si hosts. The rise time of the PL showed strong size dependence. The effects of the quantum confinement of excitons in nc-Si on the energy transfer process are discussed.
DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1α gene locus (2009)

Top1 inhibition by camptothecin (CPT) perturbs RNA polymerase II (Pol II) density at promoters and along transcribed genes suggesting an involvement of Top1 in Pol II pausing. Here, we demonstrate that Top1 inhibition favors Pol II escape from a promoter-proximal pausing site of the human HIF-1alpha gene in living cells. Interestingly, alternative splicing at exon 11 was markedly altered in nascent HIF-1alpha mRNAs, and chromatin structure was also affected with enhanced histone acetylation and reduced nucleosome density in a manner dependent on cdk activity. Moreover, CPT increases transcription of a novel long RNA (5'aHIF1alpha), antisense to human HIF-1alpha mRNA, and a known antisense RNA at the 3'-end of the gene, while decreasing mRNA levels under normoxic and hypoxic conditions. The effects require Top1, but are independent from Top1-induced replicative DNA damage. Chromatin RNA immunoprecipitation results showed that CPT can activate antisense transcription mediated by cyclin-dependent kinase (cdk) activity. Thus, Top1 inhibition can trigger a transcriptional stress, involving antisense transcription and increased chromatin accessibility, which is dependent on cdk activity and deregulated Pol II pausing. A changed balance of antisense transcripts and mRNAs may then lead to altered regulation of HIF-1alpha activity in human cancer cells.
Cationic Polymerization of Styrene in Solution and Aqueous Suspension Using B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> as a Water-Tolerant Lewis Acid (2006)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTCationic Polymerization of Styrene in Solution and Aqueous Suspension Using B(C6F5)3 as a Water-Tolerant Lewis AcidSergei V. Kostjuk and François GanachaudView Author Information Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya St., 14, 220050 Minsk, Belarus, and Laboratoire de Chimie Macromoléculaire, UMR 5076 CNRS/ENSCM, 8 Rue de l'Ecole Normale, 34296 Montpellier Cedex, France Cite this: Macromolecules 2006, 39, 9, 3110–3113Publication Date (Web):April 8, 2006Publication History Received12 December 2005Revised21 March 2006Published online8 April 2006Published inissue 1 May 2006https://pubs.acs.org/doi/10.1021/ma052650zhttps://doi.org/10.1021/ma052650zrapid-communicationACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views1431Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cationic polymerization,Monomers,Polymerization,Styrenes,Suspensions Get e-Alerts
Micropreparative capillary electrophoresis of DNA by direct transfer onto a membrane (1997)

We have developed a new technique for the collection of DNA fragments separated by capillary electrophoresis, by direct transfer from the capillary outlet to a positively charged membrane. Transfer and post-run detection of two different nonradioactively labeled DNA standards, ranging in size from 150 bp to 2 kbp and 120 bp to 23 kbp are presented, and discussed. Capillary electrophoresis with direct blotting presents several advantages over the blotting from gels: the separation is faster and requires less manual steps, the resolution is higher, and each DNA fragment is collected into a very concentrated spot on the membrane due to the small surface of the capillary outlet and to a design of the collection device inducing a refocusing of field lines across the hybridization membrane. Therefore, very small amounts of DNA (in the pg range) can be detected. This fraction collection makes further analysis of the sample possible, e.g. by hybridization, thus suppressing one of the major present limitations of the capillary electrophoresis technique for DNA analysis.
Tele-Impedance based stiffness and motion augmentation for a knee exoskeleton device (2013)

In this paper, a knee exoskeleton device and its Tele-Impedance based assistive control scheme is presented. The exoskeleton device is an inherently compliant actuated system that was implemented based on the series elastic actuation (SEA) to provide improved and intrinsically soft interaction behaviour. Details of the exoskeleton design are presented. A detailed musculoskeletal model was developed and experimentally identified in order to map electromyographic signals to the antagonistic muscle torques, acting on the human knee joint. The estimated muscle torques are used in order to determine the user's intent and joint stiffness trend. These reference signals are exploited by a novel Tele-Impedance controller which is applied to a knee exoskeleton device to provide assistance and stiffness augmentation to the user's knee joint. Experimental trials of a standing-up motion task were carried out for evaluation of the proposed control strategy. The results indicate that the proposed knee exoskeleton device and control scheme can effectively generate assistive actions that are intrinsically and naturally controlled by the user muscle activity.
Th1/Th2 cell dichotomy in acquired immunity to <i>Bordetella pertussis</i>: variables in the <i>in vivo</i> priming and <i>in vitro</i> cytokine detection techniques affect the classification of T‐cell subsets as Th1, Th2 or Th0 (1996)

In studies of the mechanism of immunity to Bordetella pertussis in a murine respiratory infection model, we have previously demonstrated that natural infection of immunization with a whole cell vaccine induces a potent protective immune response, which is mediated by T-helper type-1 (Th1) cells. In contrast an acellular vaccine generates Th2 cells and is associated with delayed bacterial clearance following respiratory challenge. In the present study we have investigated the apparent Th1/Th2 cell dichotomy in acquired immunity and have examined the factors that affect their induction or detection. The cytokine profiles of B. pertussis-specific T cells in immune animals were determined using antigen-stimulated ex vivo spleen cells or CD4+ T-cell lines and clones established in the presence of interleukin-2 (IL-2) or IL-4. Antigen-specific T cells derived from mice immunized with the acellular vaccine were almost exclusively of the Th2 cell type. In contrast, T-cell lines and clones established following respiratory infection or immunization with the whole cell vaccine were predominantly of the Th1 type. However, a proportion of T cells from convalescent mice, especially when cultured in the presence of IL-4, secreted IL-4 and IL-5 with or without detectable IL-2 and interferon-gamma (IFN-gamma), suggesting that Th0 or Th2 cells were also primed during natural infection in vivo. Furthermore, when mice were assessed 6 months after infection, spleen cells produced significant levels of IL-4 and IL-5, which were not evident at 6 weeks. The route of immunization and the genetic background of the mice were also found to influence the preferential priming of Th1 cells, and this was directly related to the level of protection against respiratory or intracerebral (i.c.) challenge. Our findings underline the critical role of CD4+ Th1 cells in immunity to B. pertussis, but also demonstrate that a number of factors in the in vivo priming and in vitro restimulation can skew the apparent dominance of one Th cell type over another.
Can Deep Learning Revolutionize Mobile Sensing? (2015)

Sensor-equipped smartphones and wearables are transforming a variety of mobile apps ranging from health monitoring to digital assistants. However, reliably inferring user behavior and context from noisy and complex sensor data collected under mobile device constraints remains an open problem, and a key bottleneck to sensor app development. In recent years, advances in the field of deep learning have resulted in nearly unprecedented gains in related inference tasks such as speech and object recognition. However, although mobile sensing shares many of the same data modeling challenges, we have yet to see deep learning be systematically studied within the sensing domain. If deep learning could lead to significantly more robust and efficient mobile sensor inference it would revolutionize the field by rapidly expanding the number of sensor apps ready for mainstream usage.
Field map estimation with a region growing scheme for iterative 3‐point water‐fat decomposition (2005)

Robust fat suppression techniques are required for many clinical applications. Multi-echo water-fat separation methods are relatively insensitive to B(0) field inhomogeneity compared to the fat saturation method. Estimation of this field inhomogeneity, or field map, is an essential and important step, which is well known to have ambiguity. For an iterative water-fat decomposition method recently proposed, ambiguities still exist, but are more complex in nature. They were studied by analytical expressions and simulations. To avoid convergence to incorrect field map solutions, an initial guess closer to the true field map is necessary. This can be achieved using a region growing process, which correlates the estimation among neighboring pixels. Further improvement in stability is achieved using a low-resolution reconstruction to guide the selection of the starting pixels for the region growing. The proposed method was implemented and shown to significantly improve the algorithm's immunity to field inhomogeneity.
Evidence for Placental Abnormality as the Major Cause of Mortality in First-Trimester Somatic Cell Cloned Bovine Fetuses1 (2000)

The production of cloned animals is, at present, an inefficient process. This study focused on the fetal losses that occur between Days 30-90 of gestation. Fetal and placental characteristics were studied from Days 30-90 of gestation using transrectal ultrasonography, maternal pregnancy specific protein b (PSPb) levels, and postslaughter collection of fetal tissue. Pregnancy rates at Day 30 were similar for recipient cows carrying nuclear transfer (NT) and control embryos (45% [54/120] vs. 58% [11/19]), although multiple NT embryos were often transferred into recipients. From Days 30-90, 82% of NT fetuses died, whereas all control pregnancies remained viable. Crown-rump (CR) length was less in those fetuses that were destined to die before Day 90, but no significant difference was found between the CR lengths of NT and control fetuses that survived to Day 90. Maternal PSPb levels at Days 30 and 50 of gestation were not predictive of fetal survival to Day 90. The placentas of six cloned and four control (in vivo or in vitro fertilized) bovine pregnancies were compared between Days 35 and 60 of gestation. Two cloned placentas showed rudimentary development, as indicated by flat, cuboidal trophoblastic epithelium and reduced vascularization, whereas two others possessed a reduced number of barely discernable cotyledonary areas. The remaining two cloned placentas were similar to the controls, although one contained hemorrhagic cotyledons. Poor viability of cloned fetuses during Days 35-60 was associated with either rudimentary or marginal chorioallantoic development. Our findings suggest that future research should focus on factors that promote placental and vascular growth and on fetomaternal interactions that promote placental attachment and villous formation.
Supine breast MRI (2011)

The presented supine breast MRI achieved an image quality comparable to diagnostic breast MRI. Since supine positioning is common in many clinical applications such as ultrasound-guided breast biopsy or breast-conserving surgery, the registration of the supine images will aid these applications.
Chronic myelogenous leukaemia (CML): an update. (2007)

The management of chronic myelogenous leukaemia (CML) has undergone a major change over the past 5 years. All newly diagnosed patients of CML are candidates for imatinib mesylate therapy. Almost 95% of patients with early chronic phase CML achieve complete haematological remission (CHR) and nearly 80% achieve complete cytogenetic response (CGR; 0% Philadelphia [Ph] chromosome-positive metaphases). These responses are stable in most patients with a risk of relapse of 4%-6% per year. For patients with advanced CML (accelerated phase and blast crisis), achievement of CHR and major (complete and partial) CGR occurs in 25%-37% and 10%-30% of patients, respectively. Most investigators agree that patients who fail to achieve CHR by 12 weeks, have partial cytogenetic response (< 35% Ph-positive metaphases) at 12 months, have CGR by 18 months, who relapse after initial response to imatinib, and those with a high Sokal score or in an advanced phase of CML should be considered for allogeneic stem cell transplantation (SCT). Despite Ph negativity with imatinib treatment, most patients continue to remain BCR-ABL positive on molecular studies, and require treatment indefinitely. Identification of patients at high risk for relapse and understanding the mechanisms to unravel resistance to imatinib are current areas of active research.