gebhart/patrepeval huggingface dataset:
Sedimentary Environment and Sequence Stratigraphy of Late Quaternary Deposits in the East China Sea (2013)

High-resolution (Chirp and Sparker system) seismic profiles were analyzed to investigate the sedimentary environment and sequence stratigraphy of the late Quaternary deposits in the East China Sea. Echo types in the study are divided into three major echo types which are classified as flat (transgressive sediment sheets, relict sands, and Holocene muds), mounded (tidal ridges), and irregular echoes (channels). Sequence analysis of high-resolution seismic profiles reveals that the shelf deposits form a succession of high-frequency (fifth-order) sequences consisting of three depositional sequences (DI, DII, and DIII) developed during the late Quaternary. The depositional sequence includes five sedimentary units, each with different seismic facies and geometry: (1) regressive estuarine/deltaic wedge (unit J1), (2) regressive deltaic/offshore deposits (unit J2), (3) low-stand deltaic wedge with incised-channel fill (unit J3), (4) transgressive estuarine/deltaic complex (unit J4-a) and sand ridges/sheet (unit J4-b), and (5) recent mud (unit J5). The results (correlation of echo types and depositional sequences, sedimentary features, and sequence stratigraphic interpretation etc.) of this study suggest that the late Quaternary deposits of the East China Sea were formed by complex sedimentary processes and systems under the influence of tidal action, sea-level change, and an enormous bulk of sediment inflow from adjacent rivers.
Cloning, molecular characterization, and expression of an endo-polygalacturonase-encoding gene from Saccharomyces cerevisiae IM1-8b (1998)

A structural polygalacturonase-encoding gene (PGU1) from Saccharomyces cerevisiae IM1-8b was cloned and sequenced. The predicted protein comprises 361 amino acids, with a signal peptide between residues 1 and 18 and two potential glycosylation points in residues 318 and 330. The putative active site is a conserved histidine in position 222. This polygalacturonase showed 54% homology with the fungal ones and only 24% homology with their plant and bacterial counterparts. The gene is present in a single gene copy per haploid genome and it is detected in all strains, regardless of their phenotype. The expression of PGU1 gene in several strains of S. cerevisiae revealed that the polygalacturonase activity depended on the plasmid used and also on the genetic background of each strain but in all cases the enzymatic activity increased.
Magnetic Resonance Imaging in Detecting Acute Oedematous and Haemorrhagic Pancreatitis: An Experimental Study in Pigs (1989)

The present study was undertaken to evaluate the role of magnetic resonance imaging (MRI) in the diagnosis of pancreatic inflammation. It was focused on the use of ultra-low- and low-field MRI imagers because of the good results achieved with them in detecting intracranial oedema and haemorrhage. In addition, there are 16 ultra-low-field MRI imagers in clinical use in the world. Nineteen piglets were examined by computed tomography (CT) and then by two MRI prototype imagers operating at 0.02 and 0.17 T. The level of the pancreas was selected on CT. Oedematous pancreatitis was induced in 9 animals by intraductal injection of autologous bile and haemorrhagic form in 7 animals by intraductal injection of 15% Na-taurocholate-trypsin with simultaneous intravenous secretin injection. After 6 or 24 h the animals were re-examined by both CT and MRI. The results show that haemorrhagic-necrotizing pancreatitis can well be differentiated from oedematous pancreatitis by CT. On MRI using an ultra-low or low magnetic field the pancreas was difficult to identify and the different forms of pancreatitis could not be differentiated. Thus, at present CT with or without contrast enhancement is superior to ultra-low-field MRI in detecting and estimating the severity of acute pancreatitis. Further progress in the MRI techniques probably improves the results in the future.
Edge Routing with Fixed Node Positions (2008)

The two basic problems of graph drawing – drawing of nodes and drawing of edges – are often handled by one algorithm that finds suitable positions for both nodes and edges. However, there are situations where positions of nodes are fixed, for instance if they were defined by the user or the exact position of the nodes is somehow significant. In these cases we need an algorithm that draws only the edges no matter what the positions of the nodes are. This paper presents one such algorithm. We present the very basic version of the algorithm followed by two ways of improving it to produce better looking and clearer results.
Measurement of dielectric loss tangent at cryogenic temperature using superconducting film resonator (2015)

We demonstrate that the superconducting film resonator can be used to accurately and quantitatively measure the microwave dielectric loss tangent of a variety of materials. Compared to traditional dielectric resonator loaded metal cavity method, it has advantage of small sample size (~2–3 orders of magnitude smaller than the old method), and much higher sensitivity to measure small loss tangent values as small as 10−5 at around 7 GHz band at cryogenic temperatures. This method can be utilized widely in study of mechanism of microwave loss at cryogenic temperature range, which is extremely important in superconducting microwave application areas, such as novel super quantum computers.
Influence of exogenous ras and p53 on P-glycoprotein function in immortalized rodent fibroblasts. (1995)

The ability of ras oncogenes and mutant p53 to activate reporter gene expression from human and rodent mdr1 gene promoters was described, although functional significance of this finding was unclear. We analyzed the influence of various forms of recombinant human ras and p53 on the mdr1 gene expression and P-glycoprotein (Pgp) function in rodent immortalized fibroblasts. The ras genes, in addition to activation of exogenous human mdr1 gene promoter, caused an increase in (i) expression of endogenous mdr1 mRNA, (ii) Pgp activity as determined by flow cytometry analysis of Rhodamine 123 exclusion, and (iii) resistance of cells to the cytotoxic action of colchicine and some other drugs. To elucidate whether the same signalling pathway is responsible for multidrug resistance induced by various oncogenes and protein kinase C (PKC), we tested the effects of v-mos and the PKC agonist 12-O-tetradecanoylphorbol-13-acetate. Similarly to cells transformed by ras, a Rat1 subline transformed by the v-mos oncogene was characterized by decreased drug sensitivity. On the contrary, Rat1 cells treated with the protein kinase C agonist 12-O-tetradecanoylphorbol-13-acetate showed neither increased mdr1 mRNA expression nor stimulation of Pgp function. Introduction by retrovirus-mediated gene transfer of wild-type p53 into Rat1 cells or into murine p53-deficient 10(1) and 10(3) cells did not change the Pgp function significantly, whereas in Rat1 cells transformed by activated N-ras or v-mos, expression of wild-type p53 caused partial reversion of oncogene-induced drug resistance.(ABSTRACT TRUNCATED AT 250 WORDS)
Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα (1999)

We have previously shown that a mixture of dietary conjugated derivatives of linoleic acid (conjugated linoleic acid, CLA) induces peroxisome proliferator-responsive enzymes and modulates hepatic lipid metabolism in vivo. The present studies demonstrate that CLA is a high affinity ligand and activator of peroxisome proliferator-activated receptor alpha (PPARalpha) and induces accumulation of PPAR-responsive mRNAs in a rat hepatoma cell line. Using a scintillation proximity assay (SPA), CLA isomers were shown to be ligands for human PPARalpha with a rank order of potency of (9Z,11E)>(10E,12Z)>(9E,11E)> furan-CLA (IC(50) values from 140 nm to 400 nm). Levels of acyl-CoA oxidase (ACO), liver fatty acid-binding protein (L-FABP), and cytochrome P450IVA1 (CYP4A1) mRNA were induced by CLA in FaO hepatoma cells. Even though linoleate and CLA were incorporated into lipids of hepatoma cells to the same extent, linoleate had little or no effect on ACO, CYP4A1, or L-FABP mRNA. In agreement with its binding potency, (9Z,11E)-CLA was the most efficacious PPARalpha activator in the mouse PPARalpha-GAL4(UAS)(5)-CAT reporter system. These data indicate that CLA is a ligand and activator of PPARalpha and its effects on lipid metabolism may be attributed to transcriptional events associated with this nuclear receptor. Also, (9Z,11E)-CLA is one of the most avid fatty acids yet described as a PPARalpha ligand.
Reliable Memories with Subline Accesses (2007)

We study memories protected with error control codes, in which the memory's contents are organized in lines which are read and written to in isolation from other lines. In these memories the available redundancy is structured so as to protect individual lines rather than the entire memory as a whole. Often designers wish to read and write only parts of the memory line, as in some instances this leads to various favorable system design tradeoffs, including better power consumption, increased data access concurrency, etc. (alternatively one may say that designers sometimes would prefer smaller line sizes). Nevertheless when designing systems with such subline accesses it is often found that in order to mantain a given level of reliability, the total amount of redundancy allocated in the memory needs to be increased beyond desirable levels. In this work, we initiate a study of the problem of structuring error control codes to allow subline accesses with good tradeoffs between reliability and redundancy. We motivate and explore a setting in which a "double-lookup" protocol is used in conjunction with certain types of two-level codes, whereby error detection is attained in a first level and error correction using the second level is performed whenever errors are detected in the first level. We obtain lower bounds on redundancy for a given level of reliability and offer a code construction that attains this bound for a certain important class of parameters. We also introduce an alternate construction which allows us to find longer codes under restrictions of the Galois field size used in the codes.
Clonidine for treatment of postoperative pain: a dose‐finding study (2002)

The aim of this double-blind randomized study was to evaluate the optimal intravenous dose of clonidine administrated during the peri-operative period, after lumbar hemilaminectomy for herniated disk repair. The "optimal intravenous dose" was defined as that providing minimal analgesic request, stable haemodynamic profile and a minimal sedation score during 12h after extubation. Eighty adult patients, ASA physical status I-II, undergoing lumbar hemilaminectomy for herniated disk (L(4)-L(5), L(5)-S(1)) were included in the study. All the patients were randomly assigned to one of four study groups (A, B, C, D), 20 patients each. The same standardized general anaesthesia was performed for each group. Thirty minutes before the end of surgery, group A, B and C patients received three different loading doses of intravenous clonidine (5 microg/kg, 3 microg/kg, 2 microg/kg respectively), followed by the same infusion of intravenous clonidine (0.3 microg/kg per hour). Group D patients received a bolus dose and a continuous infusion of NaCl 0.9%. In the recovery unit, postoperative pain was treated by a patient-controlled analgesia device, containing morphine. Pain relief was evaluated by the total morphine requirement during the postoperative period. Systolic blood pressure (SBP), heart rate and sedation were also noted during the first 12h postoperatively. Intravenous clonidine decreased morphine requirements in a dose-dependent manner. Group A, B, C and D patients requested 5 +/- 2, 11 +/- 3, 19 +/- 4 and 29 +/- 8 doses of morphine respectively. Clonidine also affected SBP in a dose-related manner. Group A, B and C patients had an SBP decrease respectively of 26 +/- 3%, 7 +/- 4% and 2 +/- 2% compared with basic values while, at the same time, in group D patients no SBP variation was registered. In conclusion, this study demonstrates that, when sedation and analgesic effect of clonidine is required, 3 microg/kg bolus dose followed by a continuous infusion of 0.3 microg/kg per hour has to be considered the optimal intravenous dose. The higher dose of intravenous clonidine (5 microg/kg) produced better analgesia but the degree of hypotension and sedation was more severe and longer lasting; it required ephedrine administration and careful monitoring of the patient. On the other hand, the bolus of intravenous clonidine 2 microg/kg (group C) was less effective in terms of pain relief but with similar side-effects to the 3 microg/kg dosage (group B).
The HIV-1 Tat Protein: A Multifaceted Target for Novel Therapeutic Opportunities (2004)

Transcription of the integrated HIV-1 proviral genome is an essential step in the retrovirus life cycle and thus an appealing target for chemotherapeutic intervention to restrict retroviral replication. A fundamental role in this process is exerted by the viral protein Tat, a powerful transactivator of viral gene expression. This protein binds a structured RNA sequence at the 5'-ends of all nascent viral mRNAs and promotes transcription by mediating the recruitment to the viral promoter of cellular factors required for chromatin remodelling and transcriptional processivity. In addition to these transcriptional activities, Tat is released from the cells and enters neighbouring cells when present in the extracellular environment, a process that is possibly involved in HIV disease pathogenesis. Given its pleiotropic functions, the protein represents a highly appealing target for drug development. Here I will summarise the known molecular mechanisms by which Tat exerts its activities and review the currently available compounds that interfere with the process of transcriptional activation of the HIV-1 provirus.
Propagation characteristics of partially loaded two-conductor transmission line for broadband light modulators (1963)

The characteristics of two-conductor transmission lines containing two dielectrics are derived. The results are applied to broad-band traveling-wave light modulators.
The Life and Status of the Polar Bear (1965)

Polar bears are on the IUCN list of endangered species. In 1961, when there were signs of serious depletions, the Canadian Wildlife Service started a five-year research project on the polar bear's biology and ecology, and the author is engaged on this work. He points out that polar bears are a most valuable resource, especially to the Canadian Eskimos, and if their numbers are allowed to dwindle to the point at which they have to be given complete protection they will have little more than aesthetic value, which in the case of an Arctic species is limited. These extracts from a comprehensive paper on the polar bear's life history and status are reproduced from “Canadian Audubon” by kind permission of the author and editor.
Estimation of the Rock Mechanical Properties Using Conventional Log Data in North Rumaila Field (2012)

Hydrocarbon production might cause changes in dynamic reservoir properties. Thus the consideration of the mechanical stability of a formation under different conditions of drilling or production is a very important issue, and basic mechanical properties of the formation should be determined.There is considerable evidence, gathered from laboratory measurements in the field of Rock Mechanics, showing a good correlation between intrinsic rock strength and the dynamic elastic constant determined from sonic-velocity and density measurements.The values of the mechanical properties determined from log data, such as the dynamic elastic constants derived from the measurement of the elastic wave velocities in the material, should be more accurate than that determined by direct strength tests with core samples. This can be attributed to the scale effect and sampling disturbances.The aim of this study was to present methods of determining measures of some mechanical properties, from available well log data (conventional sonic, density, and gamma ray) for a well in North Rumaila field.The mechanical properties include formation strength and Poisson’s ratio. For the formation strength, combined elastic modulus (Ec) and shear modulus (G) were determined. The Poisson’s ratio was determined by using three different techniques to permit the accuracy of their values. The elastic modulus, shear modulus, and Poisson’s ratio were then correlated with depth and effective stress.The results show that combined correlations are important source of the prediction of overpressure zones which represent a major problem encountered in drilling and production process.
Variability of textural features in FDG PET images due to different acquisition modes and reconstruction parameters (2010)

Textural features such as entropy-first order, energy, maximal correlation coefficient, and low-gray level run emphasis exhibited small variations due to different acquisition modes and reconstruction parameters. Features with low level of variations are better candidates for reproducible tumor segmentation. Even though features such as contrast-NGTD, coarseness, homogeneity, and busyness have been previously used, our data indicated that these features presented large variations, therefore they could not be considered as a good candidates for tumor segmentation.
Activation of macrophages by lactoferrin: secretion of TNF‐α, IL‐8 and NO (1997)

When macrophages were cultured with lactoferrin, cytokines such as tumor necrosis factor (TNF-alpha), interleukin 8 (IL-8) and nitric oxide (NO) were secreted. Secretion of TNF-alpha peaked at 6 h of incubation in the presence of lactoferrin and then declined. About 80% of the maximum secretion of IL-8 was observed at 6 h of incubation. The concentration of IL-8 in the culture medium remained almost constant between 24-72 h. In contrast, no significant effect on NO secretion was observed at 6 h, but a significant effect was observed at 24 h and secretion gradually increased between 24-72 h. The effects of lactoferrin on the secretion of TNF-alpha, IL-8 and NO were dose-dependent and lactoferrin had a significant effect on secretion of at concentrations greater than 10 mg/ml. The use of reverse transcription-polymerase chain reaction (RT-PCR) showed that the results obtained were consistent with the cytokine secretion results. It is concluded that lactoferrin activates macrophages which result in the secretion of TNF-alpha, IL-8 and NO.
Active Dead-time optimization for wide range Flyback active-clamp converter (2016)

International audience
Evaluation by patients with heart failure of the effects of enalapril compared with hydralazine plus isosorbide dinitrate on quality of life: V-HeFT II (1993)

Background. Two new questionnaires concerning the quality of life of patients with heart failure were used in a randomized, controlled trial to determine if the patients' perceptions of the effects of enalapril on their daily activities and sense of well-being were different from those of a group treated with hydralazine and isosorbide dinitrate. Methods and Results. The questionnaires were completed at baseline and at 3 months, 6 months, and subsequently every 6 months during follow-up, which averaged 2.5 years (range, 0.5-5.7 years). Data from the questionnaires were reliable as indicated by correlation coefficients between repeated baseline scores of 0.88 and 0.87. Both treatment groups showed a progressive deterioration in quality of life as measured by both questionnaires
Novel polymeric, thio‐containing photoinitiator comprising in‐chain benzophenone and an amine coinitiator for photopolymerization (2007)

Abstract A novel thio‐containing diamine with a benzophenone structure, 4‐amino‐4′‐[4‐aminothiophenyl]benzophenone (AATBP), was synthesized. Two kinds of polymeric photoinitiators, PUPIA and PUPI, were synthesized through the polycondensation of toluene‐2,4‐diisocyanate with AATBP and/or N ‐methyldiethanolamine (MDEA). A macroamine, PUPA, was also synthesized for comparison. Fourier transform infrared, 1 H NMR, and gel permeation chromatography analyses confirmed the structures of all the polymers. The ultraviolet–visible spectra of PUPIA, PUPI, and AATBP were similar, and all exhibited the maximal absorption above 325 nm. The photopolymerization of two monomers with different functionalities, poly(propylene glycol)diacrylate and trimethylolpropane triacrylate initiated by PUPIA, PUPI/MDEA, PUPI/PUPA, AATBP/MDEA, and AATBP/PUPA, was studied through differential scanning photocalorimetry. The results showed that both PUPIA and PUPI/MDEA had high photoefficiency, and their low‐molecular‐weight counterparts could hardly initiate the photopolymerization. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 576–587, 2007
Design And Implementation of A Novel Average Current Mode PFC Controller IC (2007)

This paper analyzed quasi-steady state principles of PFC (Power Factor Correction) pre-regulator. An integrated circuit chip was design based on quasi-steady state control strategy. It features built-in average current mode control. The whole PFC design is very compact by using this chip. Very good THD performance is achieved.
Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome (2008)

Long QT syndrome (LQTS) is a heritable disease associated with ECG QT interval prolongation, ventricular tachycardia, and sudden cardiac death in young patients. Among genotyped individuals, mutations in genes encoding repolarizing K+ channels (LQT1:KCNQ1; LQT2:KCNH2) are present in approximately 90% of affected individuals. Expression of pore mutants of the human genes KCNQ1 (KvLQT1-Y315S) and KCNH2 (HERG-G628S) in the rabbit heart produced transgenic rabbits with a long QT phenotype. Prolongations of QT intervals and action potential durations were due to the elimination of IKs and IKr currents in cardiomyocytes. LQT2 rabbits showed a high incidence of spontaneous sudden cardiac death (>50% at 1 year) due to polymorphic ventricular tachycardia. Optical mapping revealed increased spatial dispersion of repolarization underlying the arrhythmias. Both transgenes caused downregulation of the remaining complementary IKr and IKs without affecting the steady state levels of the native polypeptides. Thus, the elimination of 1 repolarizing current was associated with downregulation of the reciprocal repolarizing current rather than with the compensatory upregulation observed previously in LQTS mouse models. This suggests that mutant KvLQT1 and HERG interacted with the reciprocal wild-type alpha subunits of rabbit ERG and KvLQT1, respectively. These results have implications for understanding the nature and heterogeneity of cardiac arrhythmias and sudden cardiac death.
Evolution of Steroid-Inducible <i>RP2</i> mRNA Expression in the Mouse Kidney (1987)

We have examined the structure and expression of mRNAs encoded by the androgen-inducible RP2 gene in the kidneys of nine mouse species within the genus Mus. There is considerable interspecies variation in the lengths of the major RP2 transcripts; some of this variation is due to the presence or absence of a B1 repetitive element in the 3'-untranslated region of the gene. In addition, the extent of RP2 mRNA induction by testosterone differs among the species. Two species show 10-20-fold induction, while others display a reduced response or none at all. Analysis of an interspecific hybrid indicates that the inducibility phenotype is inherited in an additive fashion. A correlation between RP2 inducibility and the time of formation of lineages within the Mus genus suggests that induction evolved in a stepwise fashion, with the acquisition of a modest hormonal response being followed by the appearance of a greater response. The interspecies variations in RP2 mRNA structure and regulation provide a useful model for the identification and study of genetic elements that elicit evolutionary alterations in steroid-modulated gene expression.