gebhart/patrepeval huggingface dataset:
Metal-on-Metal Bearings and Hypersensitivity in Patients with Artificial Hip Joints (2005)

These histological findings support the possibility of a lymphocyte-dominated immunological response. Although the prevalence of this reaction is low, the persistence or early reappearance of symptoms, including a marked joint effusion and the development of osteolysis, after primary implantation may suggest the possibility of such a reaction.
Cooperation and Competition Between Relatives (2002)

Individuals are predicted to behave more altruistically and less competitively toward their relatives, because they share a relatively high proportion of their genes (e.g., one-half for siblings and one-eighth for cousins). Consequently, by helping a relative reproduce, an individual passes its genes to the next generation, increasing their Darwinian fitness. This idea, termed kin selection, has been applied to a wide range of phenomena in systems ranging from replicating molecules to humans. Nevertheless, competition between relatives can reduce, and even totally negate, the kin-selected benefits of altruism toward relatives. Recent theoretical work has clarified the processes and selective forces underlying this effect and has demonstrated the generality of the effect of competition between relatives.
Translating diagnostic assays from the laboratory to the clinic: analytical and clinical metrics for device development and evaluation (2016)

As lab-on-a-chip health diagnostic technologies mature, there is a push to translate them from the laboratory to the clinic. For these diagnostics to achieve maximum impact on patient care, scientists and engineers developing the tests should understand the analytical and clinical statistical metrics that determine the efficacy of the test. Appreciating and using these metrics will benefit test developers by providing consistent measures to evaluate analytical and clinical test performance, as well as guide the design of tests that will most benefit clinicians and patients. This paper is broken into four sections that discuss metrics related to general stages of development including: (1) laboratory assay development (analytical sensitivity, limit of detection, analytical selectivity, and trueness/precision), (2) pre-clinical development (diagnostic sensitivity, diagnostic specificity, clinical cutoffs, and receiver-operator curves), (3) clinical use (prevalence, predictive values, and likelihood ratios), and (4) case studies from existing clinical data for tests relevant to the lab-on-a-chip community (HIV, group A strep, and chlamydia). Each section contains definitions of recommended statistical measures, as well as examples demonstrating the importance of these metrics at various stages of the development process. Increasing the use of these metrics in lab-on-a-chip research will improve the rigor of diagnostic performance reporting and provide a better understanding of how to design tests that will ultimately meet clinical needs.
Discovery of Novel <i>N</i>-β-<scp>d</scp>-Xylosylindole Derivatives as Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes (2010)

A novel series of N-linked β-D-xylosides were synthesized and evaluated for inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) in a cell-based assay. Of these, the 4-chloro-3-(4-cyclopropylbenzyl)-1-(β-D-xylopyranosyl)-1H-indole 19m was found to be the most potent inhibitor, with an EC(50) value similar to that of the natural SGLT2 inhibitor phlorizin. Further studies in Sprague-Dawley (SD) rats indicated that 19m significantly increased urine glucose excretion in a dose-dependent manner with oral administration. The antihyperglycemic effect of 19m was also observed in streptozotocin (STZ) induced diabetic SD rats. These results described here are a good starting point for further investigations into N-glycoside SGLT2 inhibitors.
Conflicts in policy-based distributed systems management (1999)

Modern distributed systems contain a large number of objects and must be capable of evolving, without shutting down the complete system, to cater for changing requirements. There is a need for distributed, automated management agents whose behavior also has to dynamically change to reflect the evolution of the system being managed. Policies are a means of specifying and influencing management behavior within a distributed system, without coding the behavior into the manager agents. Our approach is aimed at specifying implementable policies, although policies may be initially specified at the organizational level and then refined to implementable actions. We are concerned with two types of policies. Authorization policies specify what activities a manager is permitted or forbidden to do to a set of target objects and are similar to security access-control policies. Obligation policies specify what activities a manager must or must not do to a set of target objects and essentially define the duties of a manager. Conflicts can arise in the set of policies. Conflicts may also arise during the refinement process between the high level goals and the implementable policies. The system may have to cater for conflicts such as exceptions to normal authorization policies. The paper reviews policy conflicts, focusing on the problems of conflict detection and resolution. We discuss the various precedence relationships that can be established between policies in order to allow inconsistent policies to coexist within the system and present a conflict analysis tool which forms part of a role based management framework. Software development and medical environments are used as example scenarios.
RBI loosens offshore structured products restrictions. (2014)

India's banking regulator has allowed domestic banks' offshore branches in global financial centres to sell structured products that are banned onshore. But the onshore market remains closed
Gonadotropin-Releasing Hormone Increases Serum Human Chorionic Gonadotropin in Pregnant Women. (1993)

Hypothalamic decapeptide, gonadotropin-releasing hormone (GnRH) has been found to stimulate human chronic gonadotropin (hCG) secretion by trophoblast cells in vitro. To determine the biological effect of GnRH on the release of hCG in vivo, we studied the effect of the administration of GnRH on the serum levels of human chronic gonadotropin (hCG) during pregnancy. Serum hCG levels were measured before and 15, 30, and 60 min after the intravenous administration of 100 micrograms of GnRH to 22 volunteers with normal pregnancy. Nine of the 12 (75%) women responded to GnRH in the first trimester, while only 1 of the 5 women (20%) responded to GnRH in the second trimester. None of the 5 women tested in the third trimester showed a significant response of hCG to the injection of GnRH. The average increase in hCG during the first, second and third trimester was 160.7 +/- 13.5%, 111.0 +/- 7.4% and 95.0 +/- 2.3%, respectively (mean +/- SEM). Whereas the pregnant courses of all the cases were uneventful and normal, other abnormal pregnancies were also investigated with informed consents. Three patients with missed abortions also showed a significant response of hCG to GnRH (increase: 136.7 +/- 8.5%) when GnRH was administered before curettage of the uterine cavity. However, 4 patients with unruptured ectopic pregnancies did not respond to GnRH stimulation. These findings indicate that GnRH can stimulate the release of hCG by the placenta in vivo, consistent with the previous in vitro study, while the responsiveness depend on gestational age and the implantation site.
Modification of vertebrate and algal prolyl 4-hydroxylases and vertebrate lysyl hydroxylase by diethyl pyrocarbonate. Evidence for histidine residues in the catalytic site of 2-oxoglutarate-coupled dioxygenases (1992)

A search for conserved amino acid residues within the cDNA-derived amino acid sequences of 2-oxoglutarate-coupled dioxygenases revealed the presence of two distinct motifs, spaced 49-71 amino acids apart, toward the C-terminal regions of these proteins. Each of the two common motifs contains an invariant histidine residue at a conserved position. The 2-oxoglutarate-coupled dioxygenases function in diverse processes, including the post-translational hydroxylation of proline and lysine residues in vertebrate collagens and the biosynthesis of microbial cephalosporins, yet they have a common reaction mechanisms, which requires the binding of Fe2+, 2-oxoglutarate, O2 and ascorbate at the catalytic site. The two regions of homology, and specifically the identical histidines, potentially represent functionally important sites related to their catalytic activity. Modification of histidine residues by diethyl pyrocarbonate inactivated vertebrate and algal prolyl 4-hydroxylase and vertebrate lysyl hydroxylase, indicating that histidine residues function in the catalytic site of these 2-oxoglutarate-coupled dioxygenases. Inactivation was prevented by the presence of co-substrates, but not by the peptide substrate. It is proposed that the histidine residues in the conserved motifs may function as Fe(2+)-binding ligands.
Design and analysis of a CMOS SOS/SOI receiver for a radiation hard computer (2003)

Summary form only given. The design of a clock receiver with a high-capacitance output drive that required special layout considerations to obtain a high-speed input protection network is discussed. The receiver layout used a crossing poly pattern to reduce thermal hot spots and improve reliability. Also, the design ground rules for pulse current loading on the small-cross-section clock interconnect metallization lines were related to the DC current rating. Finally, by applying a weak forward bias to the body of the NFET of a ratioed CMOS inverter, it was possible to realize a more ideal TTL buffer with respect to switch point and temperature characteristics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Toxicity of 22 therapeutic compounds to six fishes (1966)

First work: Of 22 therapeutic chemicals (18 parasiticides and 4 oral bacteriostats) tested by bioassays, 16 were toxic to fish and 6 were not. Second work: Bayer 73, a molluscicide sold commercially as Bayluscide, is highly toxic to 18 species of freshwater fish. Third work: Toxicities of dimethyl sulfoxide (DMSO) to rainbow trout, brook trout, lake trout, carp, black bullhead, channel catfish, green sunfish, bluegill, and yellow perch were determined in 24-, 48-, and 96-hour static bioassays as 12° C. Fourth work: Three inexpensive pieces of labor-saving apparatus for bioassay laboratory use are described and illustrated.
Towards an understanding of apoptosis detection by SYTO dyes (2007)

The data demonstrate that loss of SYTO16 is caspase-dependent, as is not a mere indicator of Deltapsim dissipation. Commonly observed similarities between SYTO and TMRM may stem from the fast kinetics of apoptotic events once cell death is initiated.
Robot Vehicle Platoon Experiment Based on Multi-leader Vehicle Following Model (2014)

The velocity control algorithm of vehicles in vehicle platoon is applied for the platoon experience of the vehicle robots. Stability analysis of the models is performed to determine the parameters and then, the summation of sensitivities for all leader vehicles is maximized. The results show that the velocity control can be performed by the velocities of only one or two leader vehicles, the nearest leader vehicle and the lead vehicle of the platoon. The model is applied for the velocity control of the vehicle robots in the vehicle platoon. The experimental result is compared with the numerical simulation in order to confirm the validity of the model. The experimental result qualitatively agrees with the computer simulation.
Gel Permeation Chromatography (1973)

Cellulose samples which have undergone various stages of thermal decomposition were characterized for changes in molecular weight and molecular weight distribution using gel permeation chromatography (GPC) and viscometry. Calculation of cellulose molecular weights (as cellulose nitrate) from the chromatogram and polystyrene calibration curves using the extended chain length-retention volume relationship (Q factor) resulted in very poor agreement between GPC and viscometric molecular weight values. Molecular weight averages determined by GPC were approximately five times greater than those obtained by viscometric technique. Application of various hydrodynamic considerations completely corrected this problem. The effects of calibration standard distribution and range are also discussed.
Benefits of minimum-variance beamforming in medical ultrasound imaging (2009)

Recently, significant improvement in image resolution has been demonstrated by applying adaptive beamforming to medical ultrasound imaging. In this paper, we have used the minimum-variance beamformer to show how the low sidelobe levels and narrow beamwidth of adaptive methods can be used, not only to increase resolution, but also to enhance imaging in several ways. By using a minimum-variance beamformer instead of delay-and-sum on reception, reduced aperture, higher frame rates, or increased depth of penetration can be achieved without sacrificing image quality. We demonstrate comparable resolution on images of wire targets and a cyst phantom obtained with a 96-element, 18.5-mm transducer using delay-and-sum, and a 48-element, 9.25-mm transducer using minimum variance. To increase frame rate, fewer and wider transmit beams in combination with several parallel receive beams may be used. We show comparable resolution to delay-and-sum using minimum variance, 1/4th of the number of transmit beams and 4 parallel receive beams, potentially increasing the frame rate by 4. Finally, we show that by lowering the frequency of the transmitted beam and beamforming the received data with the minimum variance beamformer, increased depth of penetration is achieved without sacrificing lateral resolution.
MYSTICAL STATES OF CONSCIOUSNESS (1972)

The relationship of the trophotropic and ergotropic systems of autonomic-somatic integration and their relevance to a variety of emotional states and levels of consciousness is reviewed. The importance of proprioceptive afferent feedback to the reticular formation and hypothalamus for the maintenance of ergotropic responsivity is indicated together with the beneficial clinical effects of certain behavior therapies which employ skeletal muscular relaxation as a technique for modifying central nervous system arousal. The neurophysiological basis of Asian and Oriental meditation exercises is reviewed as well as the basis of Yoga ecstasy. EEG patterns in states of meditation indicate that conditions reflective of trophotropic dominance are compatible with full awareness. The failure of habituation of alpha-blocking by sensory input would appear to indicate that some ergotropic influence continues to be exerted upon the cerebral cortex in the meditation state and seems in some way to be a correlate of the heightened perceptual sensitivity reported by such subjects. Clinical observations suggest that certain formerly drug-dependent adolescents and young adults have achieved psychological benefit from systematic practice of meditation. Its potential for therapeutic benefit in certain states of anxiety, phobia, and psychosomatic disorder is suggested.
The preparation of nitrogen samples for mass-spectrographic analyses (1955)

P. F. Holt and B. P. Hughes, J. Chem. Soc., 1955, 95 DOI: 10.1039/JR9550000095
Thermodynamics of Lectin-Carbohydrate Interactions. Titration Microcalorimetry Measurements of the Binding of N-Linked Carbohydrates and Ovalbumin to Concanavalin A (1994)

The thermodynamics of binding of concanavalin A (Con A) with a series of linear and branched chain oligosaccharides including certain N-linked complex type and oligomannose type carbohydrates and a fraction of quail ovalbumin containing Man7 and Man8 oligomannose chains have been determined using titration microcalorimetry. Methyl3,6-di-O-(alpha-D-mannopyranosyl)-alpha-D-mannopyranoside, a branch chain trisaccharide moiety found in all N-linked carbohydrates which possesses approximately 60-fold higher affinity than methyl alpha-D-mannopyranoside, exhibited a change in enthalpy of binding (delta H) of -14.4 kcal mol-1 as compared to -8.2 kcal mol-1 for the monosaccharide. This demonstrates that Con A possesses an extended binding site for the trimannoside. However, a biantennary complex type carbohydrate with terminal beta (1,2)-GlcNAc residues which binds with 3-fold higher affinity than the trimannoside possesses a delta H of only -10.6 kcal mol-1. A plot of -delta H versus -T delta S for the carbohydrates in the present study showed positive deviations in -T delta S for the complex type carbohydrate, as well as alpha (1,2)-di- and trimannosyl oligosaccharides which are part of the structures of oligomannose type carbohydrates. The relative favorable changes in binding entropies of these compounds are attributed to the presence of multiple internal and terminal residues in each molecule which can independently bind to the monosaccharide binding site of the lectin. The delta H values for the complex type carbohydrate and the alpha (1,2) mannose oligosaccharides were also approximately -2.5 kcal mol-1 greater than that of methyl alpha-D-mannopyranoside, indicating some extended binding site interactions.(ABSTRACT TRUNCATED AT 250 WORDS)
Learning Mixtures of Submodular Functions for Image Collection Summarization (2014)

We address the problem of image collection summarization by learning mixtures of submodular functions. Submodularity is useful for this problem since it naturally represents characteristics such as fidelity and diversity, desirable for any summary. Several previously proposed image summarization scoring methodologies, in fact, instinctively arrived at submodularity. We provide classes of submodular compo-nent functions (including some which are instantiated via a deep neural network) over which mixtures may be learnt. We formulate the learning of such mixtures as a supervised problem via large-margin structured prediction. As a loss function, and for automatic summary scoring, we introduce a novel summary evaluation method called V-ROUGE, and test both submodular and non-submodular optimization (using the submodular-supermodular procedure) to learn a mixture of submodular functions. Interestingly, using non-submodular optimization to learn submodular functions provides the best results. We also provide a new data set consisting of 14 real-world image collections along with many human-generated ground truth summaries collected using Amazon Mechanical Turk. We compare our method with previous work on this problem and show that our learning approach outper-forms all competitors on this new data set. This paper provides, to our knowledge, the first systematic approach for quantifying the problem of image collection sum-marization, along with a new data set of image collections and human summaries. 1
A six-port network analyzer load-pull system for active load tuning (1990)

An experimental six-port network analyzer has been used as a load-pull system in an active load tuning configuration. It is shown that by using a dual six-port reflectometer and an appropriate calibration procedure, it is possible to measure at the same reference plane the ratio between the incident and reflected waves and the power flow at the output of the test transistor. Using these two values the simulated load impedance seen by a transistor and the microwave power delivered to the simulated load are calculated. Experimental results on microwave transistor characterization confirm the validity of this method. This technique uses less hardware than conventional methods, and presents a comparable accuracy to conventional techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
"Custom generic" test programs for reusable test systems-methodology and implementation examples (2002)

The paper outlines the requirements for a reusable test executive and reusable test programs. The concepts "custom generic test programs", "smart parametrization" and test program sets are introduced. Next the process of creating test program sets (TPS) from generic test programs, using a TPS editor, is described. Implementation examples are presented throughout the paper.
Field Test of Video Game Trainer (1992)

A field study was conducted at the US Army Aviation Center to determine whether workload-coping and attention-management skills developed through structured video game experience would generalize to flight training. Three groups of 24 trainees were compared: (1) One received 10 hours of training on an IBM-PC version of Space Fortress, replicating an earlier study; (2) The second played a commerical video game (Apache Strike) for 10 hours which also required tracking, monitoring, situation assessment, and memory; (3) The third matched group receive no game training. Flight school records were monitored during the next 18 mos to compare performance of the three groups during initial flight training. Check ride ratings began to show an advantage for the group trained with Space Fortress by the Instrument stage of training, as predicted. Furthermore, attrition rates were lower for this group, replicating the results of an earlier study conducted by Gopher (1990) in the Israeli Air Force Flight School.
RTP Payload Format for GSM-HR Speech Codecs (2008)

This document registers a media type for the Real-time Transport
protocol (RTP) payload format, which is used for the Group Special
Mobile half-rate speech transcoding.
Crystal growth and characterization of the transition-metal phosphides copper diphosphide, nickel diphosphide, and rhodium triphosphide (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal growth and characterization of the transition-metal phosphides copper diphosphide, nickel diphosphide, and rhodium triphosphideJ. P. Odile, S. Soled, C. A. Castro, and A. WoldCite this: Inorg. Chem. 1978, 17, 2, 283–286Publication Date (Print):February 1, 1978Publication History Published online1 May 2002Published inissue 1 February 1978https://pubs.acs.org/doi/10.1021/ic50180a018https://doi.org/10.1021/ic50180a018research-articleACS PublicationsRequest reuse permissionsArticle Views823Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Cluster Synthesis. Part 28. New Platinum‐Cobalt Carbonyl Cluster Complexes and Products Obtained from Their Reactions with Alkynes. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.