gebhart/patrepeval huggingface dataset:
A fast pipelined CORDIC-based adaptive lattice filter (1993)

CORDIC-based adaptive lattice prediction algorithms and a pipelined CORDIC architecture for unnormalized lattice predictors are presented. One directly updates the CORDIC rotation angles theta /sub i/, i=1 . . . N, rather than the predictor unnormalized reflection coefficients, k/sub i/=tanh theta /sub i/. This updating scheme guarantees the minimum phase condition and will take full advantage of the CORDIC architecture. Moreover, to facilitate fully pipelined operation a delayed updating algorithm which updates the rotation angle based on delayed prediction errors is developed. This algorithm leads to a modular architecture and fast throughput VLSI implementation. The authors also study the application of the delayed updating algorithm to adaptive QRS detection, for the analysis of electrocardiographic (ECG) signals.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Efficient buffer capacity and scheduler setting computation for soft real-time stream processing applications (2007)

Soft real-time applications that process data streams can often be intuitively described as dataflow process networks. In this paper we present a novel analysis technique to compute conservative estimates of the required buffer capacities in such process networks. With the same analysis technique scheduler settings can be verified. Unlike many other soft real-time analysis techniques, it is guaranteed that the desired throughput is obtained for the input stream that is used to characterize the application.
Transatlantic Transport Research: Strategy and Scope (2006)

The field of transportation research is in full motion. The need to address sustainability aspects of transportation prompts both intriguing policy questions and fascinating research challenges. On both sides of the Atlantic a great variety of research strategies and projects have been developed to cope with relevant research questions. The STELLA Transatlantic network aims to focus the attention on these issues with a view to the exchange of information, the execution of comparative research and the establishment of relevant network activities in order to design a future research agenda. The paper introduces the nature of these research questions from a transatlantic perspective and presents the contours of a realistic policy research agenda for transportation in a sustainability context.
Efficient and Stable Delivery of Multiple Genes to Fish Cells by a Modified Recombinant Baculovirus System (2018)

The recombinant baculovirus has been widely used as an efficient tool to mediate gene delivery into mammalian cells but has barely been used in fish cells. In the present study, we constructed a recombinant baculovirus containing the dual-promoter cytomegalovirus (CMV) and white spot syndrome virus (WSSV) immediate-early gene 1 (ie1) (WSSV ie1), followed by a puromycin⁻green fluorescent protein (Puro-GFP, <i>pf</i>) or puromycin⁻red fluorescent protein (Puro-RFP, <i>pr</i>) cassette, which simultaneously allowed for easy observation, rapid titer determination, drug selection, and exogenous gene expression. This recombinant baculovirus was successfully transduced into fish cells, including <i>Mylopharyngodon piceus</i> bladder (MPB), fin (MPF), and kidney (MPK); <i>Oryzias latipes</i> spermatogonia (SG3); and <i>Danio rerio</i> embryonic fibroblast (ZF4) cells. Stable transgenic cell lines were generated after drug selection, which was further verified by Western blot. A cell monoclonal formation assay proved the stable heredity of transgenic MPB cells. In addition, a recombinant baculovirus containing a <i>pr</i> cassette and four transcription factors for induced pluripotent stem cells (iPSC) was constructed and transduced into ZF4 cells, and these exogenous genes were simultaneously delivered and transcribed efficiently in drug-selected ZF4 cells, proving the practicability of this modified recombinant baculovirus system. We also proved that the WSSV ie1 promoter had robust activity in fish cells in vitro and in vivo. Taken together, this modified recombinant baculovirus can be a favorable transgenic tool to obtain transient or stable transgenic fish cells.
Frequency-dependent signal windowing (2002)

Signal windowing is a temporal weighting operation whereby a signal is multiplied by a function that pays more emphasis on desired parts of the signal and typically attenuates it outside this span, normally to zero, in order to result in a finite support (nonzero part). In audio and acoustics applications it is quite common that better frequency resolution is desirable at low frequencies, while at high frequencies better time resolution calls for a shorter analysis or processing window. In this paper methods to realize and utilize frequency-dependent signal windowing are presented that exhibit this desirable frequency-dependent property. Particularly methods based on time-frequency warping and rewarping of signals are discussed. Audio examples are presented where this technique is found useful.
Ultra-high power, low RIN and narrow linewidth lasers for C-band DWDM +100km fiber optic link (2011)

We report advancement in C-band DWDM lasers with ultra-high coupled optical power (>;100mW) operated at 500mA. The laser also showed excellent RIN (≥-168dB) and narrow linewidth (<;25kHz) suitable for +100km transmission. Life test (>;3000hr) performance was robust.
Work Class ROVs for Operations in 4000 Meters of Water Depth: Prestige Wreck Fuel Recovery Project (2005)

Abstract The wreck of the 'Prestige' oil tanker resulted in one of the worst natural disasters occurring in Spain's recent history. The oil tanker, carrying 77,000 Tm of fuel oil, was affected by a storm near the north-western coast of Spain; after some days of uncontrolled sailing, the ship broke in two and sank, in some 4,000 m. of water, with an unknown quantity of the cargo still remaining in its tanks. Repsol YPF, though in no way connected to the vessel or its cargo, was appointed by the Spanish government to recover the fuel remaining inside the wreck. Subsequently, Repsol YPF selected Sonsub Limited to be the main contractor. Due to the urgent need to extract the remaining fuel, and avoid further environmental damage, Repsol YPF and Sonsub were obliged to design and develop a group of innovative tools, which allowed the operation at such depths, within a very short time frame. This paper describes the upgrading, testing and approval of Sonsub's 150 HP work class Innovator ROVs to permit operations to be performed in water depths up to 4,000 meters, with particular focus on the offshore tasks that were to be carried out to recover the fuel oil in the wreck of the 'Prestige'. These operations required the use of innovative deepwater equipment and procedures, both due to the water depth and the atypical activities that needed to be performed, including the involvement of numerous vessels on the surface, simultaneous ROV operations in nearly 4,000 meters, the tapping onto the wreck's tanks, the transfer of extremely viscous fuel into specially designed shuttles and their final recovery and offloading into a dynamically positioned FSO. The Prestige Recovery Project has won Repsol YPF the prestigious Energy Engineering Project of the Year at the Platts Global Energy Awards for 2004. Introduction The single hull tanker 'Prestige', at the time in the hands of the Greek ship-owner 'Mare Shipping Inc.', reported difficulties on November the 13th, 2002, while in a storm 21 miles off the Spanish North coast. Soon after, the tanker began to spill its cargo of some 77,000 Tm of heavy oil fuel. Nearly a week later, on November 19th, 2002, the ship broke in two and sank, some 240 km from the North West coast of Spain. Two shipwrecks were left: the bow section sank to 3,830 meters while the stern section came to rest in 3,565 meters of water. Among others, the main challenge of the project was associated with the heavy-duty works to be carried out in 4,000 meters of water particularly the risk management associated with a complex operation involving new technology and the strict need to protect the environment. Work-class remote operated vehicles (ROVs) rated for operations in 4000 m did not at that time exist, so two models were selected for the upgrading, Sonsub's Innovator and Thales´ G3 series.
Aromatherapy in childbirth: a pilot randomised controlled trial (2007)

This study demonstrated that it is possible to undertake an RCT using aromatherapy as an intervention to examine a range of intrapartum outcomes, and it provides useful information for future sample size calculations.
Generation and characterization of dimeric small immunoproteins specific for neuroblastoma associated antigen GD2 (2004)

GD2 is a disialoganglioside expressed at high density on the surface of malignant cells of neuroectodermal origin, especially in neuroblastoma (NB) and melanoma. Since its expression in normal tissues is very restricted, GD2 represents an excellent target for neuroectodermal tumor targeting. Mini-antibody technology allows the production of dimeric single-chain antibodies, also called small immunoproteins (SIPs), which are composed of a scFv fused to a dimerizing domain of immunoglobulin heavy chains. Dimerization results in an increase of the total apparent affinity and a slower clearance in vivo than scFvs. These properties make SIPs very attractive molecules for tumor targeting. We isolated the variable regions from an anti-GD2 monoclonal antibody and exploited the SIP technology to generate two novel anti-GD2 SIPs. The first anti-GD2 SIP is a fully murine molecule containing the CH3 domain of mouse IgG1, whereas the second construct is a hybrid mouse-human molecule containing the CH4 domain of human IgE. Both mini-antibodies were successfully produced and shown to retain binding specificity as well as an affinity similar to that of the original antibody.
Molecular Evidence for the Functional Role of Dopamine D<sub>3</sub>Receptor in the Morphine-Induced Rewarding Effect and Hyperlocomotion (2003)

The aim of the present study was to investigate the role of dopamine D(3) receptors in the rewarding effect and hyperlocomotion induced by a prototypical mu-opioid receptor agonist morphine using dopamine D(3) receptor knock-out mice. The mu-opioid receptor in the brain determined by the [tylosil-3,5-(3)H(N)]-[D-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin binding assay was not significantly changed by a deletion of the dopamine D(3) receptor gene. Furthermore, we found that no significant differences in G-protein activation by morphine in the limbic forebrain and lower midbrain were noted between the two genotypes. These results suggest that the function of the mu-opioid receptor itself was not affected by a deletion of the dopamine D(3) receptor gene. To ascertain the morphine-induced rewarding effect in both genotypes, the conditioned place preference paradigm was performed. Deletion of the dopamine D(3) receptor gene resulted in a remarkable enhancement of the morphine-induced rewarding effect. Furthermore, knock-out mice with deletions of the dopamine D(3) receptor revealed a dramatic potentiation of morphine-induced hyperlocomotion. Under these conditions, a loss of the dopamine D(3) receptor gene had no effect on the basal levels of dopamine and the increased dopamine turnover by morphine in the limbic forebrain. These findings provide further evidence that dopamine D(3) receptor contributes to the postsynaptically negative modulation of the mesolimbic dopaminergic pathway that is associated with the rewarding effect and hyperlocomotion through the stimulation of mu-opioid receptors induced by morphine in the mouse.
5G in E-Commerce Activities (2018)

5G services, on their own or in combination with other technologies, are likely to have a transformative impact on e-commerce activities.
Macrophage differentiation and function in health and disease (2008)

Macrophages exist in almost all animals. In some invertebrates, mesenchymal cells, endothelial cells or fibroblast-like cells can transform into macrophages. In vertebrates, primitive macrophages first develop in yolk sac hematopoiesis and differentiate into fetal macrophages. Monocytes are differentiated from hematopoietic stem cells in the late stage of fetal hematopoietic organs and bone marrow. Macrophages serve as an effector in metabolism and host defense. Depletion of macrophages severely reduced bilirubin production and host resistance to infection. Macrophage scavenger receptors are involved in host defense. Macrophage growth factors are critical for macrophage differentiation and function. In macrophage colony-stimulating factor (M-CSF)-deficient osteopetrotic mice, monocytes, tissue macrophages and osteoclasts are deficient. Granulocyte-macrophage colony-stimulating factor (GM-CSF)-deficient mice develop alveolar proteinosis due to impaired surfactant catabolism by alveolar macrophages. Accumulation of glucocerebroside in macrophages due to the deficiency of glucocerebrosidase in lysosomes produces Gaucher cells. Macrophages in the arterial wall incorporate chemically modified low-density lipoprotein (LDL) and transform into foam cells. Binding oxidized LDL to liver X receptor alpha (LXRalpha) upregulates the expression of its target genes, which act as cholesterol removers from macrophages. Inflammatory signals downregulate the expression of LXRalpha and enhance lipid accumulation. Thus, macrophages play a pivotal role in metabolism and host defense.
The prospects for new treatments in age-related macular degeneration. (1993)

The prospects for new treatments in age-related macular degeneration
Carbamates and N-Nitrocarbamates (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbamates and N-NitrocarbamatesHoward M. Curry and J. Philip MasonCite this: J. Am. Chem. Soc. 1951, 73, 11, 5043–5046Publication Date (Print):November 1, 1951Publication History Published online1 May 2002Published inissue 1 November 1951https://pubs.acs.org/doi/10.1021/ja01155a007https://doi.org/10.1021/ja01155a007research-articleACS PublicationsRequest reuse permissionsArticle Views621Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recognition of vehicles silhouette using combination of classifiers (2002)

This article investigates the combination of neural networks in committees for pattern recognition. For such, three neural networks were trained to recognize vehicles using a dataset composed by 946 vehicles silhouette, each silhouette formed by 18 characteristics. After the networks have been trained the results achieved by the individual neural networks were combined using parallel combination. Two type of decisions were used: hierarchical decision and majority decision. The results obtained by each combination were compared with those achieved by the individual networks. The experiments were performed following the Proben1 methodology proposed by Prechelt (1994).
Expanding Finance-Based Scheduling to Devise Overall-Optimized Project Schedules (2006)

Construction contractors often finance projects using bank credit lines that allow contractors to withdraw money up to certain credit limits. Finance-based scheduling provides schedules that ensure that the contractor’s indebtedness at any time during the construction stage does not exceed the credit limit. Generally, constricted credit limits tend to yield prolonged schedules. Provided that credit limits can be adequately relaxed, compressed schedules of compressed-duration activities can be attained. Devising a compressed schedule calls for the incorporation of time-cost trade-off (TCT) analysis to strike a balance between the decreased overhead costs and the increased direct costs of the activities. Since employing TCT analysis usually causes great fluctuations in the daily resource requirements by mixing compressed-duration activities of high resource demand with others of low resource demand, therefore, the need for resource management techniques becomes inevitable to ensure efficient utilization of resources. This note used genetic algorithms to expand finance-based scheduling to devise schedules for relaxed credit limits. A prototype system was developed and coded using VISUAL BASIC, then demonstrated using a five-activity example project. The prototype was validated by comparing the results with those obtained by using the integer programming. Expanding finance-based scheduling to handle the whole spectrum of credit limits helps devise overall-optimized schedules that consider cash, time, cost, and resources.
DEVELOPMENT OF A SYNTHETIC MEAT FLAVOR MIXTURE BY USING SURFACE RESPONSE METHODOLOGY (1980)

ABSTRACT A synthetic model meat flavor system was developed by panel testing of various meat flavor precursors at different levels by predicting optimum concentrations using surface response methodology. The final flavor system consisted of an autoclaved mixture of simple sugars, amino acids, 5‐nucleotides, glycoprotein, monosodium glutamate, and salt with fat as an optional component. Results demonstrated that the sulfur‐containing ammo acids and simple sugars played an important role in flavor development, whereas, the other components either masked the harsh sulfury taste or enhanced the meaty flavor. The surface response method was shown to be a good technique for predicting the optimal level of components in the formulation, although panelists were not able to differentiate between small differences in the levels of components in the mixture. Subjection of the final formulation to the panel in comparison to five commercial meat flavor extracts and an authentic beef extract showed it to be equal or superior to all of the commercial samples and nearly equal to authentic beef extract.
Voice control of the pan-European digital mobile radio system (2003)

The DTX (discontinuous transmission) system that has been standardized by CEPT for the pan-European digital mobile radio system is described. In this mode the transmitter is switched on when a user begins to talk and switched off again when he or she stops. There are two reasons for using DTX: to increase the number of radio channels (by 100% or more) which can be accommodated in a given bandwidth and to reduce the power drain in hand portable equipment. It is noted that, while adding little degradation to the speech channel and very little additional cost, the DTX will increase considerably the capacity of the system. Particular attention is given to the voice activity detector, the comfort noise subsystem, speech frame substitution, objective and subjective testing, and complexity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Memantine as an Augmentation Therapy for Anxiety Disorders (2012)

Objective. Glutamate, an excitatory neurotransmitter in the central nervous system (CNS), may play a role in the development of anxiety. Memantine partially blocks N-methyl-D-aspartate (NMDA) receptors' glutamate channels located in the CNS. This paper evaluates memantine as an augmentation therapy for treatment of anxiety. Methods. 15 consecutive partially responding anxious patients were treated with adjunctive memantine for 10 weeks. Memantine was dosed 5-20 mg/day. Result. Memantine augmentation resulted in clinically relevant reduction in anxiety symptoms when compared to baseline. Forty percent of patients achieved remission (HAM-A ≥ 7). Memantine improved sleep quality. Mean dose was 14 mg/d (range 5-20 mg/d). Typical adverse events included nausea and headache. Conclusion. The NMDA receptor antagonist memantine may be an effective augmentation therapy in patients with treatment-resistant anxiety.
Enantioselective Synthesis of Chromanones Bearing Quaternary Substituted Stereocenters Catalyzed by (1<i>R</i>)-Camphor-Derived <i>N</i>-Heterocyclic Carbenes (2015)

A catalytic asymmetric intramolecular crossed-benzoin reaction for the synthesis of chromanones by novel camphor-derived N-heterocyclic carbenes is described. The corresponding chromanones bearing quaternary stereogenic centers were isolated in high yields with high to excellent enantioselectivity.
Modulation of intein activity by its neighboring extein substrates (2009)

Inteins comprise a large family of phylogenetically widespread self-splicing protein catalysts that colonize diverse host proteins. The evolutionary and functional relationship between the intein and the split-host protein, the exteins, is largely unknown. To probe an association, we developed an in vivo and in vitro intein assay based on FRET. The FRET assay reports cleavage of the intein from its N-terminal extein. Applying this assay to randomized extein libraries, we show that the nature of the extein substrate bordering the intein can profoundly influence intein activity. Residues proximal to the intein-splicing junction in both N- and C-terminal exteins can accelerate the N-terminal cleavage rate by >4-fold or attenuate cleavage by 1,000-fold, both resulting in compromised self-splicing efficiency. The existence and the magnitude of extein effects require consideration for maximizing the utility of inteins in biotechnological applications, and they predict biases in intein integration sites in nature.
Interferon and TNF family soluble inflammatory mediators are detected prior to and increase at Systemic Lupus Erythematosus classification in serum samples from military personnel acquired from the Department of Defense Serum Repository (P3087) (2013)

Abstract Processes that lead to clinical illness in SLE years before diagnosis are not well characterized. This study evaluates the temporal relationship between autoantibody production, cytokine levels and the onset of SLE. Serial sera from 60 SLE cases before diagnosis with no ACR criteria to SLE classification (average timespan=4.4 years) and matched healthy controls (HC) were obtained from the DODSR. Sera samples were tested for autoantibodies (BioPlex2200), C-reactive protein (hs-CRP), Von Willebrand’s Factor (VWF) and 32 soluble inflammatory mediators, including cytokines, chemokines, and soluble receptors. Patient samples before ACR classification had significant (p &lt; 0.01) alterations in 16 soluble mediators of inflammation, as well as VWF and hs-CRP. TNF Receptor levels, TNFRI, TNFRII, BLyS, and APRIL, dramatically increased as lupus classification approached (p &lt; 0.001). The increase in TNFR shedding parallels the accumulation of autoantibodies in SLE cases. Interferon (IFN)-associated mediators of inflammation, IFN-γ, IP-10, MIG, and MIP-1α (p &lt; 0.01), were also increased leading up to classification. That these alterations are present prior to the transition to active SLE suggests that multiple perturbations in immune-mediated inflammatory processes occur long before clinical classification and suggest that high-risk, pre-clinical individuals, can be identified before their illness is clinically manifested and damage occurs.