gebhart/patrepeval huggingface dataset:
A POWER AND AREA EFFICIENT 65 nm CMOS DELAY-LINE ADC FOR ON-CHIP VOLTAGE SENSING (2013)

This paper presents a 4-bit windowed delay-line analog-to-digital converter (ADC) implemented in 65 nm CMOS technology for VLSI dynamic voltage scaling power management applications. Good linearity is achieved in the proposed power and area efficient ADC without the use of resistors for compensation. The circuit performance was analyzed theoretically and verified experimentally. The measured DNL is within ±0.25 LSB and INL ±0.15 LSB. It occupies an area of 0.009 mm 2 . With a sampling rate of 4 MHz, the ADC consumes 14 μW with an ENOB of 4.1 and voltage sensing range from 0.87 V to 1.32 V.
Rapid herpes simplex virus susceptibility testing using an enzyme-linked immunosorbent assay performed in situ on fixed virus-infected monolayers (1987)

An enzyme-linked immunosorbent assay was performed directly on fixed, virus-infected cell monolayers to rapidly determine the susceptibility of herpes simplex virus to antiviral drugs. Susceptibility determinations by this method correlated well with those obtained by plaque reduction assay and avoided some of the drawbacks of other methods currently available.
A reconfigurable and fault-tolerant VLSI multiprocessor array (1981)

Multiprocessor arrays have the property of regularity, enabling a low-cost VLSI implementation. However, multiprocessor systems with a fixed structure tend to be error prone and restricted to specialized applications, which makes them less attractive to the semiconductor industry. Consequently, reconfigurability and fault-tolerance are desirable features of a multiprocessor array. A multiprocessor array with a flexible structure can be adapted to many applications and may restructure itself upon failure of a processor, to avoid using faulty processors.The objective of this work is to demonstrate the feasibility of a multiprocessor array having these properties. An example of such an array is introduced, and distributed structuring algorithms for it are presented. A novel strategy for internal testing and for identification of faulty processors is developed, and the structuring algorithms are modified to accommodate faulty processors.
Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury (2011)

Therapy with mesenchymal stem cells (MSCs) has showed to be promising due to its immunomodulatory function. Traumatic brain injury (TBI) triggers immune response and release of inflammatory mediators, mainly cytokines, by glial cells creating a hostile microenvironment for endogenous neural stem cells (NSCs). We investigated the effects of factors secreted by MSCs on NSC in vitro and analyzed cytokines expression in vitro in a TBI model. Our in vitro results show that MSC-secreted factors increase NSC proliferation and induce higher expression of GFAP, indicating a tendency toward differentiation into astrocytes. In vivo experiments showed that MSC injection at an acute model of brain injury diminishes a broad profile of cytokines in the tissue, suggesting that MSC-secreted factors may modulate the inflammation at the injury site, which may be of interest to the development of a favorable microenvironment for endogenous NSC and consequently to repair the injured tissue.
Genetic Analysis Of Yeast Phospholipid Biosynthesis (1991)

We have made rapid progress in recent years in identifying the genetic causes of many human diseases. However, despite this recent progress, our mechanistic understanding of these diseases is often incomplete. This is a problem because it limits our ...Read More
Shape adjustment of precision truss structures: analytical and experimental validation (1993)

The use of a limited number of actuator/sensor pairs to alter the shape or behavior of a truss structure to other desired states is explored analytically and experimentally. Feasibility of the concept is established by numerical simulation. As a demonstration, a sequence of validation tests is performed and the correlation with analysis is discussed. An existing full scale, space-erectable high precision truss structure is used for this purpose. For the most part, the test results agreed well with the analysis. However, micron-level nonlinearities were discovered in the truss behavior. The significance of these nonlinearities in precision structures and their impact on the basic premise of adaptivity is discussed.
The mass diagnosis of ankylostome infestation. (Part I) (1922)

Journal Article The mass diagnosis of ankylostome infestation. (Part I) Get access Clayton Lane, M.D. (Lond.), I.M.S. (Retd.) Clayton Lane, M.D. (Lond.), I.M.S. (Retd.) Lieut.-Colonel Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 16, Issue 5-6, 16 November 1922, Pages 274–315, https://doi.org/10.1016/S0035-9203(22)90660-1 Published: 16 November 1922
Three-dimensional fabrication of heterogeneous microstructures using soft membrane deformation and optofluidic maskless lithography (2009)

We propose a method for high-throughput generation of 3D microstructures using a membrane-mounted microfluidic channel. Utilizing an optofluidic maskless lithography system, photopolymerized 3D microstructures are fabricated in a layer-by-layer fashion with the thickness of each layer controlled by the deformation of the membrane. The combination of low numerical aperture optical systems for photopolymerization and a soft membrane for height control allows large area projection lithography with high vertical resolution, overcoming the trade-off between vertical resolution and the field-of-view. The material composition of each layer is varied using microfluidic control of photocurable resin and composite microstructures with heterogeneity in both lateral and vertical directions are generated. Using this technique, we demonstrate three-dimensional patterning of different types of cells in a hydrogel for a microfluidic platform to study co-culture and cell-to-cell interactions. The proposed technique is fast and simple, allowing parallel synthesis of complex heterogeneous 3D microstructures and in situ biomaterial patterning for microfluidic bioassays.
The Polymerization of Bovine α -Casein B (1967)

Abstract Osmotic pressure technique has been employed to investigate the polymerization of bovine αs-casein B under different experimental conditions. Results at neutral pH indicate that the polymerization of αs-casein B depends much more on ionic strength than on temperature. The number average molecular weight of αs-casein B in 0.01 m KCI, pH 7, at 20° was found to be 29,400 which corresponds to the monomer, whereas the value at 0.1 m KC1 corresponds to that of a trimer. Viscosity and diffusion data suggest that even though αs-casein B is more flexible and possibly more solvated than a common globular protein, it is much more compact than a denatured protein. The results of the optical rotatory dispersion study indicate that there is no gross conformational change as the protein is polymerized from monomer to trimer or tetramer.
Shortcut Estimation of Safety Distances of Pipelines from Explosives (1998)

Purposely or accidentally detonating explosives near pressurized gas pipelines may have severe consequences on them, ranging from permanent deformation to gas loss or even violent rupture. Owing to lack of analytical prediction models, a shortcut is proposed in this article by which conservative estimations can be obtained of the safety distance of a pipeline from an explosion source, when explosive quantity is known. Alternatively, the maximum allowable explosive quantity can be calculated, provided distance is given. If both explosive quantity and distance are given, stresses on the pipeline may be estimated. Experimentally determined ratios of circumferential to longitudinal strains found in the literature are used. This ratio depends on soil peak particle velocity in contact with the pipeline. For total stress estimations on the pipeline, either biaxial or Huber-Hencky-Mises stresses are used, the latter being more conservative. Validation of proposed method is obtained against experimental observations and results. In this prediction model the characteristics of the explosion source, of the soil, and of the pipeline are taken into account.
A scheduling expert advisor for heterogeneous environments (2002)

In this paper we discuss intelligent agent support for parallel and distributed computing in a heterogeneous environment. We provide an overview of the Bond environment and of services provided by a network on intelligent agents, then we discuss in depth the Scheduling Expert Advisor SEA. The SEA processes a high level description of a computational task provided by a user and converts it into a set of facts and rules. An expert system starts the execution of one program or a group of programs based on the scheduling information compiled earlier.
Better-ear glimpsing in hearing-impaired listeners (2015)

When competing speech sounds are spatially separated, listeners can make use of the ear with the better target-to-masker ratio. Recent studies showed that listeners with normal hearing are able to efficiently make use of this "better-ear," even when it alternates between left and right ears at different times in different frequency bands, which may contribute to the ability to listen in spatialized speech mixtures. In the present study, better-ear glimpsing in listeners with bilateral sensorineural hearing impairment, who perform poorly in spatialized speech mixtures, was investigated. The results suggest that this deficit is not related to better-ear glimpsing.
Theoretical Description and Performance Analysis of Various IEEE 802.11 Standards (2016)

With the increasing requirements of fast intranet, fast connection, fast uploading and downloading speed, IEEE established the 802.11 group. IEEE 802.11, Wireless Local Area Network (WLAN) is a wireless broadband technology. The products based on 802.11 provide reduced data rates in order to maintain the connectivity at far distant from the access point. Hence, its popularity comes from its simplicity, high data rate, ease installation, low cost, high range and consolidated handoff. To follow the trend, this paper presents the basic introduction of IEEE 802.11 standard and its family. As the data rate supports by the original IEEE 802.11 is too low, the IEEE ratified it and form other (IEEE 802.11a/b/g/n/ac) standards. This paper also provides a huge description of various standards of IEEE 802.11 and major differences between them. The operation modes and the protocol architecture of IEEE 802.11 standard are also introduced in this article. In this paper, the IEEE 802.11n channel models and the BER performance of IEEE 802.11 are also simulated using the MATLAB.
Autostereoscopy becomes holography: historical connections (2001)

Holography, in the form of interactive holographic video, promises to fulfil some of the long-time promises of "no glasses" 3D image communication. However, the computational demands of holographic video remain extremely high, and threaten to slow down the technology beyond acceptable response rates. Faster image response is made possible by using holographic stereograms instead of true, fully-computed holograms. Holographic stereograms find their inspiration in older autostereoscopic imaging technologies that date back to as early as 1862.
Plasma membrane components of adherens junctions (Review) (2002)

This review focuses on the three known plasma membrane components of adherens junctions: E-cadherin, nectin-2 and vezatin. The structures of these three components are discussed, with particular emphasis on the molecular mechanisms by which E-cadherin and nectin-2 promote cell adhesion.
Designing for ultra-mobile interaction : experiences and a method (2010)

Usability methodology has matured into a well-defined, industrially relevant field with its own findings, theories, and tools, with roots in applying information technology to user interfaces ranging from control rooms to computers, and more recently to mobile communications devices. The purpose is regularly to find out the users’ goals and to test whether a design fulfils the usability criteria. Properly applied, usability methods provide reliable and repeatable results, and are excellent tools in fine-tuning existing solutions. The challenges of usability methodologies are in finding new concepts and predicting their characteristics before testing, especially when it comes to the relatively young field of mobile user interfaces. Current usability methods concentrate on utilising available user-interface technologies. They do not provide means to clearly identify, e.g., the potential of auditory or haptic output, or gestural input. Consequently, these new interaction techniques are rarely used, and the long-envisioned useful multimodal user interfaces are yet to appear, despite their assumed and existing potential in mobile devices. Even the most advocated and well-known multimodal interaction concepts, such as combined manual pointing and natural language processing, have not materialised in applications. An apparent problem is the lack of a way to utilise a usage environment analysis in finding out user requirements that could be met with multimodal user interfaces. To harness the full potential of multimodality, tools to identify both little or unused and overloaded modalities in current usage contexts are needed. Such tools would also help in putting possibly existing novel interaction paradigms in context and pointing out possible deficiencies in them. In this thesis, a novel framework for analysing the usage environment from a user-centric perspective is presented. Based on the findings, a designer can decide between offering a set of multiple devices utilising various user-interface modalities, or a single device that offers relevant modalities, perhaps by adapting to the usage environment. Furthermore, new techniques for creating mobile user interfaces utilising various modalities are proposed. The framework has evolved from the experiences gathered from the designs of experimental and actual product-level uniand multimodal user interface solutions for mobile devices. It has generated novel multimodal interaction and interface techniques that can be used as building blocks in system designs.
ChemInform Abstract: REACTIONS OF HEXACHLOROCYCLOPENTADIENE WITH SOME ORGANOSILICON COMPOUNDS CONTAINING ‐C‐C‐SI(CH3)2‐GROUPING (1975)

Abstract Hexachlor‐cyclopentadien (I) sezt sich bei 70°C mit Trimethylsilyl‐diacetylen (II) während 7 Stdn. zum Bicycloheptadienderivat (III) um.
Partial Enzymatic Deglycosylation Preserves the Structure of Cleaved Recombinant HIV-1 Envelope Glycoprotein Trimers (2012)

The trimeric envelope glycoprotein complex (Env) is the focus of vaccine development programs aimed at generating protective humoral responses to human immunodeficiency virus type 1 (HIV-1). N-Linked glycans, which constitute almost half of the molecular mass of the external Env domains, produce considerable structural heterogeneity and are a major impediment to crystallization studies. Moreover, by shielding the peptide backbone, glycans can block attempts to generate neutralizing antibodies against a substantial subset of potential epitopes when Env proteins are used as immunogens. Here, we describe the partial deglycosylation of soluble, cleaved recombinant Env trimers by inhibition of the synthesis of complex N-glycans during Env production, followed by treatment with glycosidases under conditions that preserve Env trimer integrity. The partially deglycosylated trimers are stable, and neither abnormally sensitive to proteolytic digestion nor prone to aggregation. Moreover, the deglycosylated trimers retain or increase their ability to bind CD4 and antibodies that are directed to conformational epitopes, including the CD4-binding site and the V3 region. However, as expected, they do not react with glycan-dependent antibodies 2G12 and PGT123, or the C-type lectin receptor DC-SIGN. Electron microscopic analysis shows that partially deglycosylated trimers have a structure similar to fully glycosylated trimers, indicating that removal of glycans does not substantially perturb the structural integrity of the trimer. The glycan-depleted Env trimers should be useful for structural and immunogenicity studies.
Optoacoustic spectroscopy for real-time monitoring of strongly light-absorbing solutions in applications to analytical chemistry (2013)

An optoacoustic technique for solutions of strongly light-absorbing analytes at 0.1-0.01 mol l(-1) is proposed. The technique is based on the wide-band forward mode detection of temporal profiles of laser-generated ultrasonic pulses (optoacoustic signals). The leading edge of the signal repeats the distribution of the laser fluence in the medium, which makes it possible to determine its optical absorption and investigate its dynamics during a reaction. The range of light-absorption coefficients starts from 1 to 5 and reaches 10(4) to 10(5) cm(-1). The determination of iron(II) as ferroin shows the possibility of probing 0.1 mol l(-1) of iron(II), which was not previously achieved for this reaction by optical spectroscopy. To further prove the concept, kinetic measurements for ferroin decomposition at the level of 0.1 mol l(-1) and at high pHs are performed. The results are compared with spectrophotometry at lower concentrations and show good reproducibility and accuracy of kinetic constants.
Volatilization of Mercuric Chloride by Mercury-Resistant Plasmid-Bearing Strains of <i>Escherichia coli, Staphylococcus aureus</i> , and <i>Pseudomonas aeruginosa</i> (1973)

Several bacterial strains carrying genes determining mercury resistance on naturally occurring plasmids will convert 10(-5)m Hg(2+) (chloride) to a form of mercury which is volatile and soluble in organic solvents. The volatilization activity is induced by exposure to HgCl(2).
Erbium:YAG laser trabecular ablation (LTA) in the surgical treatment of glaucoma (1998)

Background and Objective: Laser trabecular ablation (LTA) aims to remove trabecular tissue and to open Schlemm's canal in order to improve outflow facility in glaucomatous eyes. The purpose of our study was to investigate the pressure-reducing effect of LTA in chronic open-angle glaucoma 1 year following laser surgery. Study Design/Materials and Methods: Eleven eyes of 11 patients with chronic open-angle glaucoma were treated by circumscribed laser ablation of the trabecular meshwork. We used an Erbium:YAG laser (2.94 μm) with a quartz fiber contact endoprobe (320 μm core-diameter, 385 μm coating-diameter) applying 11–30 single neighbouring laser pulses (5–7 mJ) to the trabecular meshwork by an ab-interno approach. Laser procedure was gonioscopically visualized. Results Mean maximum intraocular pressure (IOP) of all 11 patients before LTA was 36 mmHg and dropped down to 22 mmHg after a mean follow-up of 12 months following LTA; this represents an IOP decrease of 38% (P=0.008). The average number of medications per eye dropped from 2.8 to 1.5 per eye (P=0.021). Conclusion Although IOP lowering effect of Erbium:YAG laser trabecular ablation did not prove as effective as in filtering procedures, LTA might be a valuable alternative in glaucoma surgery especially in order to avoid conjunctival scarring and postoperative hypotony. Lasers Surg. Med. 23:104–110, 1998. © 1998 Wiley-Liss, Inc.
Fabrication of SAW Resonators for Improved Long Term Aging (1978)

Surface acoustic wave resonator oscillators with long term aging rates approaching 1 part per billion per day (0.2 parts per million per year) have been built and tested. The 160 MHz, oneport resonators used in this experiment were made with etched groove arrays and aluminum transducers on rotated Y-cut quartz substrates. They were mounted, packaged, and sealed using techniques developed for precision bulk wave resonators. The devices were actively aged in oscillator circuits at 57 degrees centigrade. The processes used to fabricate and test these devices are discussed and test results are presented.
<i>In vivo</i> gene silencing of CD81 by lentiviral expression of small interference RNAs suppresses cocaine‐induced behaviour (2005)

The tetraspanin CD81 is induced in the mesolimbic dopaminergic pathway after cocaine administration. To further investigate its role, a regulatable lentivirus (Lenti-CD81) bearing the CD81 gene under the control of a tetracycline-inducible promoter and lentiviruses expressing short hairpin RNA (shRNA) targeted against CD81 (Lenti-CD81-shRNAs) have been prepared. Infection of HEK293T cells in vitro with Lenti-CD81-shRNAs resulted in 96.5% gene silencing (from quantitative real-time PCR(qRT-PCR) and immunocytochemistry). In vivo delivery of Lenti-CD81-shRNA into the nucleus accumbens or ventral tegmental area resulted in 91.3 and 94% silencing of endogenous CD81, respectively. Stereotaxic injection of Lenti-CD81 into these regions, resulting in CD81 overexpression, induced a four- to fivefold increase in locomotor activity after chronic cocaine administration, which returned to basal levels when Lenti-CD81-shRNA had been coinjected or when CD81 expression was blocked by doxycycline. Furthermore, silencing endogenous CD81 in vivo resulted in a significant decrease in locomotor activity over controls, again suppressing cocaine-induced behaviour.
Communication vulnerable patients in the pediatric ICU: Enhancing care through augmentative and alternative communication (2010)

Children in pediatric intensive care units (PICUs) may experience a broad range of motor, sensory, cognitive, and linguistic difficulties that make it difficult for them to communicate effectively. Being unable to communicate is emotionally frightening for children and can lead to an increase in sentinel events, medical errors and extended lengths of stay. Implementation of augmentative and alternative communication (AAC) tools and strategies can address the communication needs of children in the PICU by enabling them to communicate their wants, needs and feelings to healthcare providers and family members and participate in their own care more productively. Hospitals around the world are increasingly recognizing and addressing patients' needs for communication access and have begun to implement communication screenings and assessments and interventions at admission and throughout the hospital stay. New standards for all American hospitals, in fact, mandate efforts to improve patient communication. When patient-provider communication improves, treatment success goes up, hospital-caused errors decrease and patient and family satisfaction improve. This article describes three phases of intervention for communication vulnerable children in the PICU and provides examples of treatment approaches that ensure communication access as their medical condition changes.