gebhart/patrepeval huggingface dataset:
Investigation on surge testing for winding insulation fault detection in an online environment (2009)

A breakdown of the electrical insulation system causes catastrophic failure of the electrical machine and brings large process downtime losses. Preventive maintenance and online monitoring are some of the methods to improve reliability and reduce unscheduled downtime. One of the main reasons for failure is the breakdown of the stator insulation. The offline surge test is the most commonly used offline test to assess the condition of the turn insulation. There is no online monitoring method that is applicable to low voltage machines and has the same capabilities as the surge test. This paper investigates the applicability of the surge test in an online environment and shows possibilities and limitations of the online test. The investigtion is verified by experimental results.
Concave Pit-Containing Scaffold Surfaces Improve Stem Cell-Derived Osteoblast Performance and Lead to Significant Bone Tissue Formation (2007)

In conclusion, surface microcavities appear to support a more vigorous osteogenic response of stem cells and should be used in the design of therapeutic substrates to improve bone repair and bioengineering applications in the future.
Signal Jump Detection Process (2017)

Now a days we see that various types of accidents happens on the road. In India many accidents are caused due to human negligence. License Plate detection and recognition is a key technique in most of the traffic related applications such as signal jumping road traffic monitoring, airport gate monitoring, speed monitoring and Automatic parking access control .It is simply the ability to automatically extract and recognition of the vehicle license number plate's character from a captured image .In this paper, we try to give an enhance view of the signal jump detection and recognition of number plate.
α‐Metallierte Isocyanide in der Organischen Synthese (1974)

Abstract α‐Alkalimetallierte Isocyanide – zugänglich aus Isocyaniden und Basen — gestatten die nucleophile Einführung von (maskierten) α‐Aminoalkylgruppen. Ein intramolekularer Ringschluß kann folgen, wenn sich ein Nucleophil in das Elektronensextett des Isocyanid‐Kohlenstoffs einlagert. Die Umsetzung der α‐alkalimetallierten Isocyanide mit Elektrophilen gestattet die schnelle und ergiebige Synthese u. a. von 2‐ und 3‐Aminoalkoholen, geradkettigen, verzweigten sowie β‐funktionellen α‐Aminosäuren, Olefinen, Vinylisocyaniden und einer Vielzahl vorwiegend fünf‐, aber auch sechs‐ und siebengliedriger Aza‐, Diaza‐, Oxaza‐ und Thiaza‐Heterocyclen.
Fipamezole (JP‐1730) is a potent α<sub>2</sub> adrenergic receptor antagonist that reduces levodopa‐induced dyskinesia in the MPTP‐lesioned primate model of Parkinson's disease (2003)

Previous studies in the MPTP-lesioned primate model of Parkinson's disease have demonstrated that alpha(2) adrenergic receptor antagonists such as idazoxan, rauwolscine, and yohimbine can alleviate L-dopa-induced dyskinesia and, in the case of idazoxan, enhance the duration of anti-parkinsonian action of L-dopa. Here we describe a novel alpha(2) antagonist, fipamezole (JP-1730), which has high affinity at human alpha(2A) (K(i), 9.2 nM), alpha(2B) (17 nM), and alpha(2C) (55 nM) receptors. In functional assays, the potent antagonist properties of JP-1730 were demonstrated by its ability to reduce adrenaline-induced (35)S-GTPgammaS binding with K(B) values of 8.4 nM, 16 nM, 4.7 nM at human alpha(2A), alpha(2B), and alpha(2C) receptors, respectively. Assessment of the ability of JP-1730 to bind to a range of 30 other binding sites showed that JP-1730 also had moderate affinity at histamine H1 and H3 receptors and the serotonin (5-HT) transporter (IC(50) 100 nM to 1 microM). In the MPTP-lesioned marmoset, JP-1730 (10 mg/kg) significantly reduced L-dopa-induced dyskinesia without compromising the anti-parkinsonian action of L-dopa. The duration of action of the combination of L-dopa and JP-1730 (10 mg/kg) was 66% greater than that of L-dopa alone. These data suggest that JP-1730 is a potent alpha(2) adrenergic receptor antagonist with potential as an anti-dyskinetic agent in the treatment of Parkinson's disease.
Cloning and characterization of a gene (msdA) encoding methylmalonic acid semialdehyde dehydrogenase from Streptomyces coelicolor (1996)

A homolog of the mmsA gene of Pseudomonas aeruginosa, which encodes methylmalonic acid semialdehyde dehydrogenase (MSDH) and is involved in valine catabolism in pseudomonads and mammals, was cloned and sequenced from Streptomyces coelicolor. Of the two open reading frames (ORFs) found, which are convergently transcribed and separated by a 62-nucleotide noncoding region, the deduced amino acid sequence of the msdA ORF (homologous to mmsA) is similar to a variety of prokaryotic and eukaryotic aldehyde dehydrogenases that utilize NAD+, particularly to the MmsA protein from P. aeruginosa. No significant similarity was found between the deduced product of ORF1 and known proteins in the databases. An S. coelicolor msdA mutant, constructed by insertion of a hygromycin resistance gene (hyg) into the msdA coding region, lost the MSDH activity and the ability to grow in a minimal medium with valine or isobutyrate as the sole carbon source but grew on propionate. The msdA::hyg mutation was complemented by introduction of the msdA gene on a plasmid. When the S. coelicolor msdA gene was overexpressed in Escherichia coli under the control of the T7 promoter, a protein of 51-kDa, corresponding to the approximate mass of the predicted S. coelicolor msdA product (52.6 kDa), and specific MSDH activity were detected. These results strongly suggest that msdA indeed encodes the MSDH that is involved in valine catabolism in S. coelicolor.
Host metabolic reprogramming in response to SARS-Cov-2 infection (2020)

Abstract Understanding the pathogenesis of SARS-CoV-2 is important for developing effective treatment strategies. Viruses hijack the host metabolism to redirect the resources for their replication and survival. How SARS-CoV-2 influences the host metabolism is still unclear. In this study, we analyzed transcriptomic data obtained from different human respiratory cell lines and patient samples (Swab, PBMC, lung biopsy, BALF) to understand the metabolic alterations in response to SARS-CoV-2 infection. For this purpose, the expression pattern of metabolic genes in the human genome-scale metabolic network model Recon3D was explored. We identified metabolic genes and pathways and reporter metabolites under each SARS-CoV-2-infected condition and compared them to identify common and unique changes in the metabolism. Our analysis revealed host-dependent dysregulation of glycolysis, mitochondrial metabolism, amino acid metabolism, glutathione metabolism, polyamine synthesis, and lipid metabolism. We observed different metabolic changes that are pro- and antiviral in nature. We generated hypotheses on how antiviral metabolism can be targeted/enhanced for reducing viral titers. These warrant further exploration with more samples and in vitro studies to test predictions.
Intrinsic limitations of doping diamonds by heavy-ion implantation (1979)

The local environment of 111In implanted into diamonds has been studied by means of the perturbed angular correlation technique as a function of annealing temperature and of implantation dose. It is found that even when the diamond is heated under vacuum to the highest possible temperature before graphitization occurs (2100 K), the implants are not driven to spherically symmetric sites in the lattice. This lack of annealing, if common to all heavy implants, may have serious consequences on the usefulness of doping of diamond by heavy-ion implantation.
Printing superparamagnetic colloidal particle arrays on patterned magnetic film (2003)

Thin ferromagnetic film patterned into isolated islands is used to direct the assembly of superparamagnetic colloidal particles into two-dimensional (2D) arrays. It is confirmed that only one particle per island is retained when particles are slightly larger than the island, whereas particles that are smaller can form various patterns on the islands. Ferromagnetic islands positioned under a template of microwells are shown to promote highly regular 2D arrays, and external uniform magnetic field can be used to bias the particles to attract or to repel from the exposed end of the ferromagnetic islands.
Native Ms: An ‘Esi’ Way to Support Structure- and Fragment-Based Drug Discovery (2009)

The success of early drug-discovery programs depends on the adequate combination of complementary and orthogonal technologies allowing hit/lead compounds to be optimized and improve therapeutic activity. Among the available biophysical methods, native MS recently emerged as an efficient method for compound-binding screening. Native MS is a highly sensitive and accurate screening technique. This review provides a description of the general approach and an overview of the possible characterization of ligand-binding properties. How native MS supports structure- and fragment-based drug research will also be discussed, with examples from the literature and internal developments. Native MS shows strong potential for in-depth characterization of ligand-binding properties. It is also a reliable screening technique in drug-discovery processes.
The Expert Consensus Guideline Series. Treatment of depression in women. (2001)

The experts reached a high level of consensus on the appropriateness of including both antidepressant medication, specifically SSRIs, and nonpharmacological modalities in treatment plans for severe depression in 4 key clinical situations unique to women. To evaluate many of the treatment options in this survey, the experts had to extrapolate beyond controlled data in comparing modalities with each other or in combination. Within the limits of expert opinion and with the expectation that future research data will take precedence, these guidelines provide some direction for addressing common clinical dilemmas in women. They can be used to inform clinicians and educate patients regarding the relative merits of a variety of interventions.
A Cyber–Physical Systems Approach to Data Center Modeling and Control for Energy Efficiency (2011)

This paper presents data centers from a cyber–physical system (CPS) perspective. Current methods for controlling information technology (IT) and cooling technology (CT) in data centers are classified according to the degree to which they take into account both cyber and physical considerations. To evaluate the potential impact of coordinated CPS strategies at the data center level, we introduce a control-oriented model that represents the data center as two coupled networks: a computational network representing the cyber dynamics and a thermal network representing the physical dynamics. These networks are coupled through the influence of the IT on both networks: servers affect both the quality of service (QoS) delivered by the computational network and the generation of heat in the thermal network. Using this model, three control strategies are evaluated with respect to their energy efficiency and computational performance: a baseline strategy that ignores CPS considerations, an uncoordinated strategy that manages the IT and CT independently, and a coordinated strategy that manages the IT and CT together to achieve optimal performance with respect to both QoS and energy efficiency. Simulation results show that the benefits to be realized from coordinating the control of IT and CT depend on the distribution and heterogeneity of the computational and cooling resources throughout the data center. A new cyber–physical index (CPI) is introduced as a measure of this combined distribution of cyber and physical effects in a given data center. We illustrate how the CPI indicates the potential impact of using coordinated CPS control strategies.
Investigation of the Electrical Properties of Microtubule Ensembles under Cell-Like Conditions (2020)

Microtubules are hollow cylindrical polymers composed of the highly negatively-charged (~23e), high dipole moment (1750 D) protein α, β- tubulin. While the roles of microtubules in chromosomal segregation, macromolecular transport, and cell migration are relatively well-understood, studies on the electrical properties of microtubules have only recently gained strong interest. Here, we show that while microtubules at physiological concentrations increase solution capacitance, free tubulin has no appreciable effect. Further, we observed a decrease in electrical resistance of solution, with charge transport peaking between 20-60 Hz in the presence of microtubules, consistent with recent findings that microtubules exhibit electric oscillations at such low frequencies. We were able to quantify the capacitance and resistance of the microtubules (MT) network at physiological tubulin concentrations to be 1.27 × 10<sup>-5</sup> F and 9.74 × 10<sup>4</sup> Ω. Our results show that in addition to macromolecular transport, microtubules also act as charge storage devices through counterionic condensation across a broad frequency spectrum. We conclude with a hypothesis of an electrically tunable cytoskeleton where the dielectric properties of tubulin are polymerisation-state dependent.
<i>L</i>-Arginine: Rediscovery in Progress (1998)

Since the recognition that L-arginine (LA) is the natural metabolic donor of nitric oxide, this amino acid has reached the medical spotlight. LA exerts favorable effects in the prevention and treatment of endothelial damage and the restoration of endothelial function in patients with cardiovascular risk factors (hypercholesterolemia, smoking, hypertension, diabetes and advanced age) or with several chronic cardiovascular disorders (coronary, peripheral and cerebral vascular disease, and mild-to-moderate heart failure). LA administration is likely to represent a potentially novel therapeutic strategy during angioplasty, coronary bypass grafting and cardiac transplantation. More conclusive research findings for the rediscovered role of this well-known substance merit close attention.
Effect of Heavy Metals on the Sorption of Hydrophobic Organic Compounds to Wood Charcoal (2007)

Black carbon (BC) is believed to be an important adsorbent of organic pollutants. A complex suite of heavy metals and organic pollutants is commonly present in many situations. An issue that has received little direct attention is the effect of heavy metals on sorption of organic compounds to BC. We found that coadsorption of Cu2+ at an environmentally relevant, comparable concentration (50 mg L-1) decreases sorption of both the polar compound, 2,4-dichlorophenol (DCP), and nonpolar compounds, 1,2-dichlorobenzene (DCB) and naphthalene (NAP), by 30-60%, as measured bythe change in the distribution coefficient (Kd). This was attributed to surface complexation of CU2+ to form hydration shells of dense water that directly compete with organics for adsorption surface area. In contrast, coadsorption of Ag+ increases sorption of the organic solutes, which was accounted for by the decline in hydrophilicity of the local region around Ag+-complexed functionalities due to softness of the cation, leading to mitigated competitive sorption of water. Coadsorption of heavy metal ions to nonporous graphite, a model of the BC graphene (polycyclic aromatic) structure that has no 0-containing groups, however, only slightly inhibits organic adsorption due to the low affinities of metal ions to graphite surface. The results of the present study showed that the presence of coexisting heavy metals greatly affects sorption of organic pollutants on BC and thereby their fate and transport.
A novel iterative data-aided channel estimation for time domain synchronous-OFDM (2009)

The classical channel estimation method in TDS-OFDM is carried out based on the PN sequence in the GI which suffers from the intersymbol interference of the previous OFDM data symbols. This paper presents a novel data-aided channel estimation method to refine the initial channel estimation obtained from PN sequence. The data symbols are rebuilt based on the log-likelihood ratio (LLR) from the output of the demapper. The second channel estimation is made based on these data symbols. The moving average within the coherence bandwidth is performed on the second channel estimation to reduce noise. Finally, the initial and second channel estimations are combined according to the minimum mean square error (MMSE) criteria. The simulation results demonstrate that the proposed method can significantly improve the mean square error (MSE) performance of the initial channel estimator and the bit error rate (BER) performance of real TDS-OFDM based systems.
Adenocarcinoma of the Bladder (1939)

No AccessJournal of Urology1 Aug 1939Adenocarcinoma of the Bladder1 Stanley R. Lowrey Stanley R. LowreyStanley R. Lowrey More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)71497-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1939 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited BySheldon C, Clayman R, Gonzalez R, Williams R and Fraley E (2018) Malignant Urachal LesionsJournal of Urology, VOL. 131, NO. 1, (1-8), Online publication date: 1-Jan-1984.Kramer S, Bredael J, Croker B, Paulson D and Glenn J (2018) Primary Non-Urachal Adenocarcinoma of the BladderJournal of Urology, VOL. 121, NO. 3, (278-281), Online publication date: 1-Mar-1979.Garyey F and Nunnery W (2018) Mucinous Adenocarcinoma of the Urachus: Review of the Literature and Report of a CaseJournal of Urology, VOL. 72, NO. 5, (860-866), Online publication date: 1-Nov-1954.Fleischman A and Mauritz E (2018) Adenocarcinoma of the Urinary BladderJournal of Urology, VOL. 47, NO. 5, (658-663), Online publication date: 1-May-1942. Volume 42Issue 2August 1939Page: 118-125 Advertisement Copyright & Permissions© 1939 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Stanley R. Lowrey More articles by this author Expand All Advertisement Loading ...
Involvement of Nitric Oxide in Survival of Random Pattern Skin Flap (1998)

A free radical gas, nitric oxide, has many useful functions when produced under physiological conditions by neurons and endothelial cells. However, excess nitric oxide has been reported to exert cytotoxic effects by direct toxicity or by reaction with superoxide. The effect of nitric oxide on the microcirculation in the periphery of a flap remains unclear, and its effect on flap survival is also unknown because nitric oxide has a dual action. Thus, we attempted to clarify the effect of nitric oxide on survival of rat random pattern skin flaps by the use of an endothelial constitutive nitric oxide synthase inhibitor (i.p. administration of 50 mg/kg N(G)-nitro-L-arginine) and the substrate of nitric oxide synthase (i.p. administration of 1 g/kg L-arginine). Three kinds of experiments were done using a total number of 120 animals: (1) time course measurement of blood flow in the flap periphery was performed using a laser Doppler flowmeter (30 rats), (2) the length of the surviving area of flaps was measured 1 week after raising the flap (60 rats), and (3) Western blot analysis was used to determine the time course of changes in the amount of endothelial constitutive nitric oxide synthase and the formation of 3-nitro-L-tyrosine, which is a marker of peroxynitrite-mediated (i.e., nitric oxide-dependent) tissue damage (30 rats). Inhibition of endothelial constitutive nitric oxide synthase by N(G)-nitro-L-arginine significantly decreased the length of the surviving area of skin flap (p < 0.01 compared with the control), which was associated with a decrease in the blood flow of the proximal portion of the flap. On the other hand, exogenous L-arginine increased the survival length of skin flap significantly (p < 0.01 compared with the control), which was associated with an increase in blood flow of the distal portion of the flap even though there was nitric oxide-mediated oxidative tissue damage. These results suggest that nitric oxide produced by endothelial constitutive nitric oxide synthase plays a role in maintaining circulation in the skin flap periphery and that L-arginine administration contributes to reduction of ischemic necrosis in the skin flap.
Indirect Subharmonic Optical Injection Locking of a Millimeter-Wave IMPATT Oscillator (1986)

Large aperture phased-array antennas operating at millimeter-wave frequencies are designed for space-based communications and imaging. Array elements are composed of active transmit-receive (T/R) modules that are phase and frequency synchronized to a reference signal at the central processing unit by a fiber-optic (FO) distribution network. The implementation of FO links, synchronizing the millimeter-wave Iocal oscillators (LO's), imposes a great challenge. This paper presents results of indirect optical injection locking of a free-running 38-GHz (Ka-band) IMPATT oscillator over the Iocking range of 2-132 MHz, depending on the injected power level (amplifier gain). In the experiment, the nonlinearity of both the laser diode and the IMPATT oscillator is exploited to achieve 12th subharmonic injection locking. The overall system FM noise degradation of the reference signal is 16 dB at 500-Hz offset. The FM noise degradation is dominated by the theoretical limit of 20 log N, where N is the frequency multiplication factor used in subharmonic injection locking. Methods by which optical injection locking may be extended into 60 and 90 GHz are demonstrated.
Effect of the Cannabinoid Receptor‐1 Antagonist Rimonabant on Inflammation in Mice With Diet‐Induced Obesity (2010)

We studied whether cannabinoid receptor (CB1) blockade with rimonabant has an anti-inflammatory effect in obese mice, and whether this effect depends on weight loss and/or diet consumption. High-fat diet (HFD)-induced obese mice were treated orally with rimonabant (HFD-R) or vehicle (HFD-V) for 4 weeks. Paired-feeding was conducted in two additional groups of obese mice to achieve either the same body weight (HFD-BW) or the same HFD intake (HFD DI) as HFD-R. All these groups of mice were maintained on HFD throughout, with mice on normal diet (ND) throughout as lean controls. Rimonabant treatment of obese mice induced marked diet-intake reduction and weight loss during the first week, which was followed by maintenance of low body weight but not diet-intake reduction. Lower HFD intake was required to reach the same degree of weight loss in HFD-BW. HFD-DI had similar weight loss initially, but then started to gain weight, reaching a higher body weight than HFD-R. Despite the same degree of weight loss, HFD-R had less fat mass and lower adipogenic gene expression than HFD-BW. Compared to HFD-V or HFD-DI, HFD-R had reduced inflammation in adipose tissue (AT) and/or liver indicated primarily by lower monocyte chemoattractant protein-1 (MCP-1) levels. However, MCP-1 levels were not significantly different between HFD-R and HFD-BW. In vitro incubation of rimonabant with AT explants did not change MCP-1 levels. Thus, rimonabant induced weight loss in obese mice by diet-intake-dependent and -independent fashions. Rimonabant decreased inflammation in obese mice, possibly through a primary effect on weight reduction.