gebhart/patrepeval huggingface dataset:
Cost-Effectiveness Comparison of Coupler Designs of Wireless Power Transfer for Electric Vehicle Dynamic Charging (2016)

This paper presents a cost-effectiveness comparison of coupler designs for wireless power transfer (WPT), meant for electric vehicle (EV) dynamic charging. The design comparison of three common types of couplers is first based on the raw material cost, output power, transfer efficiency, tolerance of horizontal offset, and flux density. Then, the optimal cost-effectiveness combination is selected for EV dynamic charging. The corresponding performances of the proposed charging system are compared and analyzed by both simulation and experimentation. The results verify the validity of the proposed dynamic charging system for EVs.
The Chloride Channel ClC-4 Contributes to Endosomal Acidification and Trafficking (2003)

Mutations in the gene coding for the chloride channel ClC-5 cause Dent's disease, a disease associated with proteinuria and renal stones. Studies in ClC-5 knockout mice suggest that this phenotype is related to defective endocytosis of low molecular weight proteins and membrane proteins by the renal proximal tubule. In this study, confocal micrographs of proximal tubules and cultured epithelial cells revealed that the related protein ClC-4 is expressed in endosomal membranes suggesting that this channel may also contribute to the function of this organelle. In support of this hypothesis, specific disruption of endogenous ClC-4 expression by transfection of ClC-4 antisense cDNA acidified endosomal pH and altered transferrin trafficking in cultured epithelial cells to the same extent as the specific disruption of ClC-5. Both channels can be co-immunoprecipitated, arguing that they may partially contribute to endosomal function as a channel complex. These studies prompt future investigation of the role of ClC-4 in renal function in health and in Dent's disease. Future studies will assess whether the severity of Dent's disease relates not only to the impact of particular mutations on ClC-5 but also on the consequences of those mutations on the functional expression of ClC-4.
Exploiting program redundancy to improve performance, cost and power consumption in embedded systems (2000)

During the last 15 years embedded systems have grown rapidly in complexity and performance to a point where they now rival the design challenges of desktop systems. Embedded systems are now targets for contradictory requirements: they are expected to occupy a small amount of physical space (e.g., low package count), be inexpensive, consume low power and be highly reliable. Regardless of the decades of intensive research and development, there are still areas that can promise significant benefits if further researched. One such area is the quality of the data which embedded system operates upon. This includes both code and data segments of an embedded system application. This work presents a unified, compiler-driven approach to solving the redundancy problem. It attempts to increase the quality of the data stream that embedded systems are operating upon while preserving the original functionality. The code size reduction is achieved by Huffman compressing or tailor encoding the ISA of the original program. The data segment size reduction is accomplished by modified Discrete Dynamic Huffman encoding. This work is the first such study that also details the design of instruction fetch mechanisms for the proposed compression schemes.
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21 (2004)

Replication protein A (RPA) is a single-stranded DNA (ssDNA) binding protein involved in various processes, including nucleotide excision repair and DNA replication. The 32 kDa subunit of RPA (RPA32) is phosphorylated in response to various DNA-damaging agents, and two protein kinases, ataxia-telangiectasia mutated (ATM) and the DNA-dependent protein kinase (DNA-PK) have been implicated in DNA damage-induced phosphorylation of RPA32. However, the relative roles of ATM and DNA-PK in the site-specific DNA damage-induced phosphorylation of RPA32 have not been reported. Here we generated a phosphospecific antibody that recognizes Thr21-phosphorylated RPA32. We show that both DNA-PK and ATM phosphorylate RPA32 on Thr21 in vitro. Ionizing radiation (IR)-induced phosphorylation of RPA32 on Thr21 was defective in ATM-deficient cells, while camptothecin (CPT)-induced phosphorylation of RPA32 on Thr21 was defective in cells lacking functional DNA-PK. Neither ATM nor DNA-PK was required for etoposide (ETOP)-induced RPA32 Thr21 phosphorylation. However, two inhibitors of the ATM- and Rad3-related (ATR) protein kinase activity prevented ETOP-induced Thr21 phosphorylation. Inhibition of DNA replication prevented both the IR- and CPT-induced phosphorylation of Thr21, whereas ETOP-induced Thr21 phosphorylation did not require active DNA replication. Thus, the regulation of RPA32 Thr21 phosphorylation by multiple DNA damage response protein kinases suggests that Thr21 phosphorylation of RPA32 is a crucial step within the DNA damage response.
Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability (2011)

The extreme pH and protease-rich environment of the upper gastrointestinal tract is a major obstacle facing orally-administered protein therapeutics, including antibodies. Through protein engineering, several Clostridium difficile toxin A-specific heavy chain antibody variable domains (V(H)Hs) were expressed with an additional disulfide bond by introducing Ala/Gly54Cys and Ile78Cys mutations. Mutant antibodies were compared to their wild-type counterparts with respect to expression yield, non-aggregation status, affinity for toxin A, circular dichroism (CD) structural signatures, thermal stability, protease resistance, and toxin A-neutralizing capacity. The mutant V(H)Hs were found to be well expressed, although with lower yields compared to wild-type counterparts, were non-aggregating monomers, retained low nM affinity for toxin A, albeit the majority showed somewhat reduced affinity compared to wild-type counterparts, and were capable of in vitro toxin A neutralization in cell-based assays. Far-UV and near-UV CD spectroscopy consistently showed shifts in peak intensity and selective peak minima for wild-type and mutant V(H)H pairs; however, the overall CD profile remained very similar. A significant increase in the thermal unfolding midpoint temperature was observed for all mutants at both neutral and acidic pH. Digestion of the V(H)Hs with the major gastrointestinal proteases, at biologically relevant concentrations, revealed a significant increase in pepsin resistance for all mutants and an increase in chymotrypsin resistance for the majority of mutants. Mutant V(H)H trypsin resistance was similar to that of wild-type V(H)Hs, although the trypsin resistance of one V(H)H mutant was significantly reduced. Therefore, the introduction of a second disulfide bond in the hydrophobic core not only increases V(H)H thermal stability at neutral pH, as previously shown, but also represents a generic strategy to increase V(H)H stability at low pH and impart protease resistance, with only minor perturbations in target binding affinities. These are all desirable characteristics for the design of protein-based oral therapeutics.
Rendezvous Maneuvers of Multiple Spacecraft Using Differential Drag Under J2 Perturbation (2008)

This research was partially supported by the Defense Advanced Research Projects Agency. This research was performed while R. Bevilacqua was holding a National Research Council Research Associateship Award at the Spacecraft Robotics Laboratory of the Naval Postgraduate School.
A mathematical model of the Calvin photosynthesis cycle (1988)

1. A mathematical model is presented for photosynthetic carbohydrate formation in C3 plants under conditions of light and carbon dioxide saturation. The model considers reactions of the Calvin cycle with triose phosphate export and starch production as main output processes, and treats concentrations of NADPH, NAD+, CO2, and H+ as fixed parameters of the system. Using equilibrium approximations for all reaction steps close to equilibrium steady-state and transient-state relationships are derived which may be used for calculation of reaction fluxes and concentrations of the 13 carbohydrate cycle intermediates, glucose 6-phosphate, glucose 1-phosphate, ATP, ADP, and inorganic (ortho)phosphate. 2. Predictions of the model were examined with the assumption that photosynthate export from the chloroplast occurs to a medium containing orthophosphate as the only exchangeable metabolite. The results indicate that the Calvin cycle may operate in a single dynamically stable steady state when the external concentration of orthophosphate does not exceed 1.9 mM. At higher concentrations of the external metabolite, the reaction system exhibits overload breakdown; the excessive rate of photosynthate export deprives the system of cycle intermediates such that the cycle activity progressively approaches zero. 3. Reactant concentrations calculated for the stable steady state that may obtain are in satisfactory agreement with those observed experimentally, and the model accounts with surprising accuracy for experimentally observed effects of external orthophosphate on the steady-state cycle activity and rate of starch production. 4. Control analyses are reported which show that most of the non-equilibrium enzymes in the system have a strong regulatory influence on the steady-state level of all of the cycle intermediates. Substrate concentration control coefficients for cycle enzymes may be positive, such that an increase in activity of an enzyme may raise the steady-state concentration of the substrate is consumes. 5. Under optimal external conditions (0.15-0.5 mM orthophosphate), reaction flux in the Calvin cycle is controlled mainly by ATP synthetase and sedoheptulose bisphosphatase; the cycle activity approaches the maximum velocity that can be supported by the latter enzyme. At lower concentrations of external orthophosphate the cycle activity is controlled almost exclusively by the phosphate translocator.(ABSTRACT TRUNCATED AT 400 WORDS)
A magnetic poly(dimethylesiloxane) composite membrane incorporated with uniformly dispersed, coated iron oxide nanoparticles (2009)

We report a new magnetic polymer membrane for MEMS application. The polymeric magnetic composite has coated iron oxide nanoparticles incorporated in a polydimethylsiloxane (PDMS) matrix. Existing magnetic polymeric materials have particle agglomeration problems, which result in rough surfaces and uneven mechanical and optical properties. We show that the use of iron oxide nanoparticles (10 nm in diameter) with fatty acid and hydrophobic coatings inhibits aggregation of particles in the PDMS polymer matrix. Agglomerated particle sizes in thin-film PDMS composites incorporated with uncoated and coated particles are 51 ± 24 µm and 1.6 ± 0.25 µm, respectively. The PDMS composites exhibit saturation magnetization of 22.8 to 23.94 emu g−1. Stress–strain curves of the composites are characterized by tensile tests. Free-standing magnetic PDMS membranes are fabricated in different sizes from 4 mm to 7 mm in diameter and with the thickness of 35.5 ± 1.5 µm. The membrane of 7 mm diameter achieves deflection of 625 µm in a 0.417 T magnetic field. The magnetic PDMS membranes may be used in micro-pumps and lab-on-a-chip applications.
Bald mutants of Streptomyces griseus that prematurely undergo key events of sporulation (1996)

To identify the structural defects of nonsporulating mutants of Streptomyces griseus, the wild-type strain and class III bald mutants were examined by using transmission electron microscopy, ultrasonic treatment, and fluorescence microscopy after the induction of submerged sporulation by phosphate starvation. In the wild-type strain, submerged sporulation was marked by the relatively synchronous formation of sporogenic hyphae, nucleoid segregation, deposition of sporulation septa, and subsequent thickening of the spore walls during maturation. All of the class III mutants prematurely synthesized sporulation septa and thick spore walls. The class IIIA and C mutants formed sporogenic hyphae earlier than the wild-type strain and underwent nucleoid segregation in parallel with sporulation septum formation. In the class IIIB (bld4) mutant, DNA segregation appeared to be uncoupled from septum formation. The results indicate that the class III mutants are defective in loci that are involved in the regulation of key events of Streptomyces morphogenesis.
Investigating Recurrence and Eligibility Traces in Deep Q-Networks (2017)

Eligibility traces in reinforcement learning are used as a bias-variance trade-off and can often speed up training time by propagating knowledge back over time-steps in a single update. We investigate the use of eligibility traces in combination with recurrent networks in the Atari domain. We illustrate the benefits of both recurrent nets and eligibility traces in some Atari games, and highlight also the importance of the optimization used in the training.
Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2'-dimethyl-4-aminobiphenyl and testosterone propionate. (1991)

The promotion effects of testosterone propionate (TP) on prostate carcinogenesis were investigated in F344 rats given the prostatic carcinogen, 3,2'-dimethyl-4-aminobiphenyl (DMAB). One group of animals received s.c. DMAB injections at a dose of 50 mg/kg body weight at 2-week intervals for a total of 10 injections along with s.c. implantations of TP-containing Silastic tubes. A second experimental group of rats was given DMAB at the same dose and intervals but each injection of DMAB was combined with 3 prior consecutive daily 100-mg/kg body weight s.c. injections of TP. After cessation of carcinogen administration, animals in these two groups received TP implants from week 21 to the end of the experiment. All surviving animals were killed at week 56 and accessory sex gland tumor incidences were compared to those in DMAB alone and other appropriate control groups. The groups given TP plus DMAB and subsequent long term administration of TP developed lesions of the dorsolateral prostate, seminal vesicles, and coagulating glands which were all invasive adenocarcinomas. Incidences were 84.2% (16 of 19 rats) and 66.7% (12 of 18 rats), respectively. Macroscopic large tumors were induced in 13 animals among which 8 demonstrated metastasis to the abdominal cavity, liver, or lung. None of the control groups except for the group given TP injections plus DMAB had equivalent tumors. Development of carcinomas of the ventral prostate, which were all of in situ type, were not increased by subsequent treatment with TP. These data thus clearly showed that TP can exert strong enhancing effects on tumor development in the dorsolateral prostate, seminal vesicles, and coagulating glands but not in the ventral prostate.
Membrane Retrofit Option for Paraffin/Olefin Separation—A Technoeconomic Evaluation (2012)

The technical and economic feasibility of a hybrid separation process in which gas separation membranes are combined with conventional distillation are assessed for the separation of ethylene from ethane and of butadiene from a C4-mixture. The potentials for increased energy efficiency and debottlenecking were determined in relation to the required membrane performances. The energy saving potential for the separation of ethylene from ethane is rather low owing to the required very high membrane selectivity. Energy savings can be expected when the membrane selectivity for ethylene is >60. However, the possibility to increase the column capacity in an existing plant by using a membrane is very high. This can become economically attractive if the membrane has a selectivity for ethylene of ≥10. In the case of butadiene separation, the energy savings can be as high as 30% depending on membrane selectivity and process configuration. This high value can be reached when the membrane selectivity for butadiene relative to saturated hydrocarbons equals 15. Again, an increase in the production capacity of butadiene can be achieved in an economic viable fashion.
Outdoor exploration and SLAM using a compressed filter (2005)

In this paper we describe the use of automatic explorationfor autonomous mapping of outdoor scenes. We describe areal-time SLAM implementation along with an autonomous explorationalgorithm. We have ...
Data-Aided and Blind Stochastic Gradient Algorithms for Widely Linear MMSE MAI Suppression for DS-CDMA (2004)

In this paper, three novel stochastic gradient algorithms for adjustment of the widely linear (WL) minimum mean-squared error (MMSE) filter for multiple access interference (MAI) suppression for direct-sequence code-division multiple access (DS-CDMA) are introduced and analyzed. In particular, we derive a data-aided WL least-mean-square (LMS) algorithm, a blind WL minimum-output-energy (MOE) algorithm, and a WL blind LMS (BLMS) algorithm. We give analytical expressions for the steady-state signal-to-interference-plus-noise ratios (SINRs) of the proposed WL algorithms, and we also investigate their speed of convergence. Wherever possible, comparisons with the corresponding linear adaptive algorithms are made. Both analytical considerations and simulations show, in good agreement, the superiority of the novel WL adaptive algorithms. Nevertheless, all proposed WL algorithms require a slightly lower computational complexity than their linear counterparts.
Priority dispatching with operation due dates in a job shop (1982)

Abstract This paper investigates the effects on job shop performance of setting and attempting to enforce operation due dates for jobs. It does so by comparing via simulation the performance of priority dispatching rules when employed to enforce operation due dates versus job due dates. The results indicate that operation due dates improve every conventional measure of job shop performance.
The Changing Immunology of Organ Transplantation (1995)

The engrafted organ becomes a chimera as the recipient's leukocytes station themselves in the transplant. Remarkably, the recipient becomes chimeric as well, in a reverse migration involving immune cells from the graft. Interactions between donor and recipient cells are tolerogenic--a process with implications for the goal of graft acceptance with minimal immunosuppression.
Isolation of morphologically intact mitochondrial nucleoids from the yeast, <i>Saccharomyces cerevisiae</i> (1987)

Mitochondrial nucleoids (mt-nucleoids) of the yeast, Saccharomyces cerevisiae, were isolated from spheroplasts of stationary phase cells and their structure and organization were investigated by fluorescence microscopy, electron microscopy, and biochemical techniques. Isolated mt-nucleoids were spherical or ovoid and 0.3-0.6 micron in diameter, and were about the same size and shape as those observed in the cell by the DAPI staining technique. Measurement of DNA content of mt-nucleoids, using a video-intensified microscope system, after DAPI staining revealed that a mt-nucleoid in spheroplasts from stationary phase cells contains, on average, 3.9 mtDNA molecules and an isolated mt-nucleoid contains, on average, 3.1. Negatively stained electron micrographs showed that mt-nucleoids consist of particles 20-50 nm in diameter. SDS-polyacrylamide gel electrophoresis of mt-nucleoids detected 20 species of polypeptides in the molecular weight range from 10 X 10(3) to 70 X 10(3). Acid-urea/SDS two-dimensional electrophoresis of acid extract from mt-nucleoids indicated that a polypeptide of 20 X 10(3) is the only major polypeptide with basic property like histones.
A universal finite memory source (1995)

An irreducible parameterization for a finite memory source is constructed in the form of a tree machine. A universal information source for the set of finite memory sources is constructed by a predictive modification of an earlier studied algorithm-Context. It is shown that this universal source incorporates any minimal data-generating tree machine in an asymptotically optimal manner in the following sense: the negative logarithm of the probability it assigns to any long typical sequence, generated by any tree machine, approaches that assigned by the tree machine at the best possible rate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Performance of four modern whole genome amplification methods for copy number variant detection in single cells (2017)

Whole genome amplification (WGA) has become an invaluable tool to perform copy number variation (CNV) detection in single, or a limited number of cells. Unfortunately, current WGA methods introduce representation bias that limits the detection of small CNVs. New WGA methods have been introduced that might have the potential to reduce this bias. We compared the performance of PicoPLEX DNA-Seq (Picoseq), DOPlify, REPLI-g and Ampli-1 WGA for aneuploidy screening and copy number analysis using shallow whole genome massively parallel sequencing (MPS), starting from single or a limited number of cells. Although the four WGA methods perform differently, they are all suited for this application.
Practical Construction Against Theoretical Approach in Fingerprinting (2006)

We consider fingerprinting under collusion attacks in the Hamming space. To model the attacks we use the framework of Somekh-Baruch and Merhav, IEEE Trans, on Inf. Th.9 vol. 51(3), 2005. We construct a family of fingerprinting codes efficient against coalition of arbitrary size. Using this family, tracing dishonest users can be done without error and in polynomial time. The number of users is exponential in the length. The proposed construction relies on centered error correcting codes. Our results have an amazing relation with an upper bound on the number of users derived by Somekh-Baruch and Merhav: dropping two assumptions that they used we construct codes beating their bound
Uniform saddlepoint approximations for ratios of quadratic forms (2008)

Ratios of quadratic forms in correlated normal variables which introduce noncentrality into the quadratic forms are considered. The denominator is assumed to be positive (with probability 1). Various serial correlation estimates such as least-squares, Yule–Walker and Burg, as well as Durbin–Watson statistics, provide important examples of such ratios. The cumulative distribution function (c.d.f.) and density for such ratios admit saddlepoint approximations. These approximations are shown to preserve uniformity of relative error over the entire range of support. Furthermore, explicit values for the limiting relative errors at the extreme edges of support are derived.
HOP: Hardware makes Obfuscation Practical (2017)

Author(s): Kartik Nayak, Christopher W. Fletcher, Ling Ren, Nishanth Chandran, Satya Lokam, Elaine Shi, Vipal Goyal Download: Paper (PDF) Date: 27 Feb 2017 Document Type: Reports Additional Documents: Slides Video Associated Event: NDSS Symposium 2017 Abstract: Program obfuscation is a central primitive in cryptography, and has important real-world applications in protecting software from IP theft. However, well … Continued
DISTURBANCES OF THE VISUAL APPARATUS IN THE TOXAEMIAS OF PREGNANCY ASSOCIATED WITH ECLAMPSIA OR THE PRE-ECLAMPTIC STATE (1935)

named writer saw in consultation with Dr. Narayanaswami Pillai of the above hospital a case of " blind- ness following eclampsia.'' "A" was a Hindu, aged 18 years; 18 months before she was nearing full term as a primipara. She had been a big strong healthy girl and never suspected anything wrong till she got fits near the time of her delivery. They were not bad and she consulted Colonel Hingston, at that time Superintendent, Madras Government Hospital for Women and Children.