gebhart/patrepeval huggingface dataset:
Measuring Athletic Facility Managers’ Knowledge Of Access And The Americans With Disabilities Act: A Pilot Study (2012)

The purpose of this exploratory research was measuring facility managers’ knowledge of the Americans with Disabilities Act (ADA), and it may assist in decreasing the gap in knowledge between facility managers and the needs of people with physical disabilities. An existing survey examining ADA knowledge was slightly modified and used for this study. Four athletic facility managers from universities in a large Bowl Championship Series conference participated in the study. Results provided a preliminary sketch of who athletic facility manages may be, and how athletic facility managers may be educating themselves and others about accessibility. This exploratory study shows that facility managers may be knowledgeable of specific ADA requirements but may not have a firm grasp on more general issues patrons with physical disabilities face and that have often been the point of contention in the courts such as parking, entranceways, seating, and sightlines. Additionally, athletic facility managers may not be seeking to expand their education on ADA-related matters or educate others on the topics, which could be a missed opportunity to position themselves as a topic expert in the field of ADA compliance for athletic facilities.
Roles of CXCL5 on migration and invasion of liver cancer cells (2014)

Inflammatory factors play a vital role in the progression of liver cancer, although exact factors and related mechanisms still remain unclear. The present study aimed at screening inflammatory factors related to liver cancer metastasis and investigating the potential mechanism by which cancer cells are recruited. We screened and validated inflammatory factors by microarray and RT-PCR. Small interfering RNA (siRNA) and recombinant protein were used to assess CXCL5 effects on the movement of liver cancer cells (LCCs). Our screening microarray demonstrated over-expression of CXCL5 in LCCs with high metastatic potentials. CXCL5 increased LCCs migration and invasion, probably through autocrine and paracrine mechanisms. CXCL5-CXCR2 and ERK1/2 pathways could play critical roles in the regulation of LCCs migration. Our data indicates that LCCs per se may act as the producer and receptor of CXCL5 responsible for liver cancer migration and invasion.
Nonvolatile hydrogenated-amorphous-silicon thin-film-transistor memory devices (2006)

The floating gate n-channel amorphous-silicon thin-film transistor nonvolatile memory device, which includes an a-Si:H layer embedded in the SiNx gate dielectric layer, has been prepared and studied. The transistor’s hysteresis of transfer characteristic curves has been used to demonstrate its memory function. A steady threshold voltage change between the “0” and “1” states has been achieved. A large charge retention time of &gt;3600s with the “write” and “erase” gap of 0.5V has been detected. This kind of device brings additional functions to the a-Si:H thin-film transistors, which can expand its application into various areas.
2,2′:6′,2′′:6′′,6‐Trioxytriphenylamine: Synthesis and Properties of the Radical Cation and Neutral Species (2005)

A flat radical: Oxygen-bridged triphenylamine 1 and its radical cation 2 were prepared. The neutral compound has a shallow bowl structure, whereas the radical cation is planar. The properties of the highly stable radical cation were clarified; such compounds have potential applicability in electronic and magnetic materials.
An analysis of the relationship between central aortic and peripheral upper limb pressure waves in man (1993)

Amplification of the pressure pulse between central and peripheral arteries renders pressure values in the upper limb an inaccurate measure of ascending aortic (AA) pressure. Accuracy could be improved by allowance for such amplification. Transfer functions (TF) for pressures between AA and brachial artery (BA):(BATF) and between AA and radial artery (RA):(RATF) were derived from high-fidelity pressure recordings obtained at cardiac catheterization in 14 patients under control conditions, and after sublingual nitroglycerine 0.3 mg. There was no significant difference in BATF under control conditions and with nitroglycerine; hence results were pooled. Control and nitroglycerine results were also pooled to obtain a single RATF. BATF and RATF moduli peaked at 5 Hz and 4 Hz, reaching 2.5 and 2.8 times the value at zero frequency respectively. Frequency-dependent changes in modulus and phase of BATF and RATF were attributable to wave travel and reflection in the upper limb. BATF and RATF were compared to published transfer functions and those derived from analysis of aortic and brachial or radial pressure waves in previous publications. Results were similar. Our BATF and RATF were used to synthesize AA pressure waves from published peripheral pulses. Correspondence was close, especially for systolic pressure which differed by 2.4 +/- 1.0 (mean +/- SEM) mmHg, whereas recorded systolic pressure differed by 20.4 +/- 2.6 (mean +/- SEM) mmHg between central and peripheral sites. Results indicate that in adult humans a single generalized TF can be used with acceptable accuracy to determine central from peripheral pressure under different conditions.(ABSTRACT TRUNCATED AT 250 WORDS)
Differences between the activities of human monoclonal IgG1 and IgG3 subclasses of anti-D(Rh) antibody in their ability to mediate red cell-binding to macrophages. (1987)

Four IgG1 and three IgG3 human monoclonal antibodies specific for the blood group D(Rh) antigen were tested for their ability to mediate red cell-binding to macrophages in vitro. The IgG3 monoclonals were found to opsonize at a density of approximately 100 molecules per red cell, whereas the IgG1 antibodies were only active at a level of 10,000 molecules per cell. There was no substantial difference between the two IgG subclasses in their ability to bind to Fc receptors on macrophages and it is suggested that the more potent opsonic activity of IgG3 is the result of the relatively long hinge, leading to greater accessibility to the Fc receptor binding site on the Fc piece.
Synthetic inhibitors of matrix metalloproteinases prevent sulfur mustard-induced epidermal-dermal separation in human skin pieces (2000)

Degradation of proteins of the basement membrane zone (BMZ) in the skin depends on the activity of proteolytic enzymes, particularly those belonging to the group of matrix metalloproteinases (MMPs). In the present study we have investigated the contribution of these enzymes to the epidermal-dermal separation in human skin pieces that had been exposed to saturated vapor of HD at 25 ÂºC. The release of MMP-1, MMP-2, MMP-3 and MMP-9 in the organ culture media by human skin pieces, that were either or not exposed to HD vapor, have been determined by using substrate zymography and ELISA. The results showed that secretion of MMP-1, -9 and -3 from control skin is inhibited after exposure to HD vapor, whereas release of the latent form of MMP-2 is somewhat enhanced by HD. The spatial and temporal distribution of the four MMPs and their naturally occurring inhibitors TIMP-1 and TIMP-2 in human skin pieces has been analyzed immunohistochemically. For each antigen staining is weak or absent in epidermis and dermis of control skin. Only minor changes in the expression of MMPs and TIMPs are observed between control skin and HDexposed skin at 6, 16, 24 or 48 h of organ culture. However, a strong proof for the involvement of MMPs in epidermal-dermal separation of HD-exposed skin has been obtained by the potent inhibition of microvesication in human skin pieces when a synthetic inhibitor of MMPs, i.e. either BB94 or BB3103, was added to the organ culture medium. These results implicate the involvement of MMPs in the pathogenesis of HD-induced vesication and suggest the use of synthetic MMP inhibitors as a novel therapeutic strategy against HDinduced vesication.
Red Reflex Examination in Neonates, Infants, and Children (2008)

Red reflex testing is an essential component of the neonatal, infant, and child physical examination. This statement, which is a revision of the previous policy statement published in 2002, describes the rationale for testing, the technique used to perform this examination, and the indications for referral to an ophthalmologist experienced in the examination of children.
Modulation of human saposin B sphingolipid-binding specificity by alternative splicing. A study with saposin B-derived synthetic peptides. (1994)

The saposins A, B, C, and D, produced by proteolytic maturation of the same precursor protein, prosaposin, are sphingolipid-binding proteins which function as activators for lysosomal enzymes involved in sphingolipid hydrolysis. The alternative splicing of the prosaposin gene results in the inclusion or exclusion of exon 8 into transcribed prosaposin mRNA through the use of alternative acceptor sites. The relative abundance of each alternatively spliced mRNA was determined by reverse transcription-polymerase chain reaction in various human tissues and cell lines. Exon 8 codes for only three amino acid residues, Gln-Asp-Gln, in the saposin B domain of prosaposin. The prosaposin mRNA containing exon 8 is the major species in cultured skin fibroblasts, brain, and pituitary glands together with a smaller amount of mRNA devoid of exon 8, whereas the prosaposin mRNA detected in liver and lymphoblasts was devoid of exon 8 insertion. Previous structural modeling studies on saposin B have suggested that the Gln-Asp-Gln insertion occurs in an amphipathic alpha-helix region of the protein which is implicated in the binding of GM1-ganglioside. We report that synthetic peptides containing the alpha-helix, with and without the Gln-Asp-Gln insertion, have different binding affinities for GM1-ganglioside, sulfatide, and sphingomyelin. The insertion of the Gln-Asp-Gln sequence completely abolishes the capacity of the peptide to bind GM1-ganglioside, whereas its affinity for sulfatide and sphingomyelin is increased about 4-fold and almost 2-fold, respectively. No significant binding of glucosylceramide was observed with both peptides. These results suggest that alternative splicing of prosaposin mRNA may change binding specificity of saposin B presumably to adapt to the variable sphingolipid composition of tissues.
Improvement of the KCF Tracking Algorithm through Object Detection (2018)

When the position of the beam projector is changed, users have to manually adjust the position. In this paper, we propose a system that can automatically correct images. In this process, the KCF (Kernelized Correlation Filter) algorithm is used for tracking the IR (Infrared) markers. We analyze the object tracking failure problem of the KCF and improve the KCF tracking algorithm that solves the problem through object detection.
Thermal Management of a Vehicle's Underhood and Underbody Using Appropriate Math-Based Analytical Tools and Methodologies (2007)

<div class="htmlview paragraph">Traditionally, powertrain generated thermal management in a vehicle's UH/UB (underhood/underbody) has relied primarily on physical testing. However, today's highly competitive marketplace is forcing the original equipment manufacturers (OEM) to constantly compress the vehicle development cycles. Under these conditions, math-based analytical tools are becoming increasingly popular. One of the key reasons for this can be attributed to their proven effectiveness in identifying and resolving thermal issues in the nascent stages of vehicle development cycle wherein no physical hardware is yet available for testing. However, accurate analytical predictions of maximum temperature at any location in a vehicle's UH/UB during a transient thermal validation procedure still remains a tremendous modeling challenge. In order to address this complex task of vehicle thermal modeling, three thermal analysis methodologies that utilize both commercial software packages and internally developed software codes, sometimes in combination, are discussed in this work. The key objective of this study, therefore, is to investigate novel approaches that would further help enhance the predictive capability of current thermal analysis methods.</div>
Do Hospital Fall Prevention Programs Work? A Systematic Review (2000)

The pooled effect of about 25% reduction in the fall rate may be a result of intervention but may also be biased by studies that used historical controls not allowing for historical trends in the fall rate before and during the intervention. The randomized controlled trials apparent lack of effect might be due to a change in practice when patients and controls were in the same unit at the same time during a study. Studies did not analyze compliance with the intervention or opportunity costs resulting from the intervention. Research and clinical programs in hospital fall prevention should pay more attention to study design and the nature of interventions.
Cell-Probe Lower Bounds for Succinct Partial Sums (2010)

The partial sums problem in succinct data structures asks to preprocess an array A[1 ‥ n] of bits into a data structure using as close to n bits as possible, and answer queries of the form . The problem has been intensely studied, and features as a subroutine in a number of succinct data structures. We show that, if we answer Rank(k) queries by probing t cells of w bits, then the space of the data structure must be at least n + n/wO(t) bits. This redundancy/probe trade-off is essentially optimal: Patrascu [FOCS'08] showed how to achieve n + n/(w/t)Ω(t) bits. We also extend our lower bound to the closely related Select queries, and to the case of sparse arrays.
Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B (2008)

NTHi induces COX-2 and PGE2 expression in a p38 MAPK and NF-kappa B-dependent manner through TLR2 in lung epithelial cells in vitro and lung tissues in vivo. The full understanding of the role of endogenous anti-inflammatory PGE2 and its regulation will bring new insight to the resolution of inflammation in pulmonary bacterial infections.
Controlling properties of field effect transistors by intermolecular cross-linking of molecular dipoles (2009)

In this study, we show that systematic molecular control over a silicon-on-insulator field effect transistor (SOI-FET) device can be achieved by controlling the Si–O–Si intermolecular interactions between adjacent trichlorosilane molecules. This is attributed to the fact that Si–O–Si intermolecular bonds between the parallel molecular dipoles change the overall charge distribution within the organic layer, and, consequently, alter the channel surface potential. Changes in the potential within the formed monolayer close to the channel alter the source-drain current and, consequently, the transistor threshold (turn on) voltage.
A new halo-pelvic apparatus (2003)

Study Design. A technical report of a new, versatile halo-pelvic apparatus for use in spinal immobilization is presented. Objectives. To show how simple modifications of existing external fixation devices allow a halo-pelvic fixation apparatus to be constructed. Summary of Background Data. Halo-pelvic fixation has been used successfully in the past for immobilization and correction of severe spinal deformities such as tuberculous kyphosis. With the advent of new spinal instrumentation systems and techniques, external immobilization of the whole spine is rarely indicated. However, on rare occasions, spine surgeons may be presented with cases in which no internal fixation has been possible. Methods. Halo-skull fixation and pelvis fixation were performed using standard techniques. A simple custom-made halo connection bar was used to connect the halo to uprights from the pelvis external fixator. Because the majority of the system makes use of standard external fixation equipment, it is easy to apply and adjust. Results. Between 1997 and 2001, this frame was successfully applied to stabilize the spines of three patients with severe tuberculous kyphosis exceeding 100°. Conclusions. One simple modification of existing external fixation equipment has allowed a new halo-pelvic device to be constructed and used effectively to immobilize the spine.
Sensitivity-enhanced nuclear magnetic resonance of biological solids (2001)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2001.
LiNbO/sub 3/ waveguide quasi-phase-matched sum-frequency generation device for optical sampling (2003)

Optical sampling using short optical pulses is an important technique for optical waveform measurements. Experiments based on type II sum-frequency generation (SFG) in bulk crystal have been reported. The SFG efficiency, however, was in the order of 10/sup -2/%/W or less. A waveguide quasi-phase-matching (QPM) structure would offer much higher efficiencies. In this paper, we present design, fabrication and characterization of a LiNbO/sub 3/ waveguide QPM-SFG device for high-efficiency optical sampling.
An Interactive System for Finding Perfect Hash Functions (1985)

The interactive implementation of this hash function algorithm presents several examples of large lexicon design, illustrating how the minimality criterion and execution efficiency can vary when various problem parameters are adjusted.
Effects of decision ambiguity level on optical receiver sensitivity (1995)

We describe the effect of a finite-decision ambiguity level on optical receiver sensitivity. A new analytic expression for the receiver sensitivity including the effect of the decision ambiguity level is obtained by modifying the well-known expression assuming an ideal decision circuit. Also obtained is a requirement for linear channel transimpedance gain or decision ambiguity level for less than 1-dB power penalty of receiver sensitivity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Adaptive test flow for mixed-signal/RF circuits using learned information from device under test (2010)

Despite their small size, analog/mixed-signal circuits start with an extensive set of parameters to test for. During production ramp up, most of these tests are dropped using statistical analysis techniques based on the dropout patterns. While effective in reducing the number of tests, this approach treats each device in an identical manner. As the statistical diversity of the devices increases due to increasing process variations, such homogeneous testing approaches may prove to be inefficient. After a number of initial measurements, device-specific information is available, which can provide clues as to where in the process space that device falls. Using this information, the test set for each device can be tailored with respect to its own statistical information. In this paper, we present an adaptive test flow for mixed-signal circuits that aims at optimizing the test set per-device basis so that more test resources can be devoted to marginal devices whereas devices that fall in the middle of the process space are passed with less testing. We also include provisions to identify potentially defective devices and test them more extensively since these devices do not conform to learned collective information. We conduct experiments on an LNA circuit in simulations and apply our techniques to production data of two distinct industrial circuits. Both the simulation results and the results on large-scale production data show that adaptive test provides the best trade-off between test time and test quality as measured in terms of defective parts per million.
Effect of temperature and humidity on the disintegration time of packaged paracetamol tablet formulations. (1994)

A study of the effect of various temperature and humidity conditions on the disintegration time of different brands of packaged paracetamol tablet formulations has been made over a period of six months. Under all the storage conditions paracetamol tablets show an increase in disintegration time ranging from 9.1 to 65.5% (200 mg tablets) and 1.2 to 150.0% (500 mg tablets) on increasing the temperature from 25 to 45 degrees C (75% RH). The increase in disintegration time on increasing the temperature from 25 to 45 degrees C (100% RH) ranges from 14.3 to 157.7% (200 mg tablets) and 15.3 to 92.3% (500 mg tablets). The overall increase in disintegration time from 25-45 degrees C at 75% and 100% RH is 36.4 to 564% (200 mg tablets) and 10.0 to 140.5% (500 mg tablets) and 101.3 to 122.9% (200 mg tablets) and 2.6 to 46.8% (500 mg tablets) respectively. These results indicate that PVC/PVDC/Al foil packaging cause relatively less change in disintegration time of the tablets compared to that of the polycoated paper and viscose film.
Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus (2015)

Mechanistic studies on gliotoxin biosynthesis and self-protection in Aspergillus fumigatus, both of which require the gliotoxin oxidoreductase GliT, have revealed a rich landscape of highly novel biochemistries, yet key aspects of this complex molecular architecture remain obscure. Here we show that an A. fumigatus ΔgliA strain is completely deficient in gliotoxin secretion but still retains the ability to efflux bisdethiobis(methylthio)gliotoxin (BmGT). This correlates with a significant increase in sensitivity to exogenous gliotoxin because gliotoxin trapped inside the cell leads to (i) activation of the gli cluster, as disabling gli cluster activation, via gliZ deletion, attenuates the sensitivity of an A. fumigatus ΔgliT strain to gliotoxin, thus implicating cluster activation as a factor in gliotoxin sensitivity, and (ii) increased methylation activity due to excess substrate (dithiol gliotoxin) for the gliotoxin bis-thiomethyltransferase GtmA. Intracellular dithiol gliotoxin is oxidized by GliT and subsequently effluxed by GliA. In the absence of GliA, gliotoxin persists in the cell and is converted to BmGT, with levels significantly higher than those in the wild type. Similarly, in the ΔgliT strain, gliotoxin oxidation is impeded, and methylation occurs unchecked, leading to significant S-adenosylmethionine (SAM) depletion and S-adenosylhomocysteine (SAH) overproduction. This in turn significantly contributes to the observed hypersensitivity of gliT-deficient A. fumigatus to gliotoxin. Our observations reveal a key role for GliT in preventing dysregulation of the methyl/methionine cycle to control intracellular SAM and SAH homeostasis during gliotoxin biosynthesis and exposure. Moreover, we reveal attenuated GliT abundance in the A. fumigatus ΔgliK strain, but not the ΔgliG strain, following exposure to gliotoxin, correlating with relative sensitivities. Overall, we illuminate new systems interactions that have evolved in gliotoxin-producing, compared to gliotoxin-naive, fungi to facilitate their cellular presence.
STRUCTURE AND SYNTHESIS OF 11,12,13-TRIHYDROXY-9<i>Z</i>,15<i>Z</i>-OCTADECADIENOIC ACIDS FROM RICE PLANT SUFFERING FROM RICE BLAST DISEASE (1986)

Abstract Structural elucidation including the absolute configuration was carried out on the trihydroxyoctadecadienoic acids isolated from rice plant suffering from rice blast disease.
<title>Two-directional spatial-carrier phase-shifting method for analysis of complex interferograms</title> (1994)

information about the phenomena tested. Recent applications require the analysis on the base of a single interferogram.Here, we address two problems: simultaneous analysis of the information about two events and analysis of interferogramwith high phase gradients in both x and y directions. The analysis of an interferogram is performed by the spatial-carrierphase-shifting method used sequentially for x and y sampling directions. The error analysis of the two procedures proposedis presented.1. INTRODUCTIONInvestigation of dynamic processes and measurements in unstable environment require an analysis on the base of