gebhart/patrepeval huggingface dataset:
Device-circuit optimization for minimal energy and power consumption in CMOS random logic networks (1997)

We demonstrate a new approach minimizing the total ofthe static and the dynamic power dissipation components in aCMOS logic network required to operate at a specified clockfrequency using joint optimization of both device and circuitdesigns for a specific logic schematic and activity profile.We present a new approach to designing ultra low-powerCMOS logic circuits by joint optimization of supply voltage,threshold voltage and device widths for a specified speedconstraints.The static (leakage) and dynamic (switching)energy components are considered and an efficient heuristicis developed that delivers over an order of magnitude savingsin power over conventional optimization methods.
Resistance of Chrysanthemum Cultivars to White Rust ( <i>Puccinia horiana</i> ) (1970)

SUMMARY A whole‐plant method for screening chrysanthemum cultivars for resistance to white rust is described. Of 270 cultivars of the florists’ chrysanthemum ( Chrysanthemum sinense Sabine) tested, 93 showed some infection. According to the severity of infection these were rated as susceptible, moderately susceptible, resistant and very resistant. The remaining two thirds were rated as practically immune or immune.
Analysis of the reflectance spectra of oil emulsion spilled on the sea surface (2014)

Airborne remote sensing appears useful for monitoring oil spill accident or detecting illegal oil discharges. In that context, hyperspectral imagery in the SWIR range shows a high potential to describe oil spills. Indeed reflectance spectra of an oil emulsion layer show a wide variety of shapes according to its thickness or emulsion rate. Although based on laboratory measurements, it seems that these two parameters are insufficient to completely describe them. It appears that the way emulsion is performed leads to different reflectance spectra. Hence this paper will present a model which tends to simulate reflectance spectra of an oil emulsion layer over the sea water. To derive an analytical expression, some approximations and assumptions will be done. The result of this model shows high similarities with laboratory measurements and seems able to simulate most of the shapes of reflectance spectra. It also shows that a key parameter to define the shape of the reflectance spectra is the statistical distribution of water bubbles size in the emulsion. The description of this distribution function, if measurable, should be integrated into the methodology of elaboration of spectral libraries in the future.
Linear Ti:Linbo 3 Modulators At 1.3 μm For Electromagnetic Field Sensing (1985)

Theory and experiment at 1.3 μm are presented to describe and compare the behavior of two kinds of channel waveguide modulators in Ti-indiffused LiNb03: Mach-Zehnder interferometers and directional couplers. Each device can be operated as a linear modulator when biased to an appropriate point, either by passive geometrical means or by application of a DC voltage. However, the device voltage responses differ, being sinusoidal for an interferometer and varying as sin2x/x2 for a directional coupler. There is good agreement between calculated and measured device responses. The linear dynamic range of each kind of modulator is reported. We have measured linearity over 76 dB and voltage sensitivities of ~ 13 μV.
Vanoxonin, a new inhibitor of thymidylate synthetase. III. Inhibition of thymidylate synthetase by vanoxonin-vanadium complex. (1985)

Quinquevalent vanadium complex with two mol of vanoxonin ligated by the two catechols was shown to be the active structure for inhibition of thymidylate synthetase. The catechol group of vanoxonin as the essential moiety for the inhibition of enzyme was further confirmed by studies of structure-activity relationships using the enzyme obtained from Ehrlich ascites carcinoma cells of mice. Vanoxonin-vanadium complex showed competitive inhibition with respect to deoxyuridylic acid but uncompetitive to 5,10-methylenetetrahydrofolate.
Anisotropic Elastography for Local Passive Properties and Active Contractility of Myocardium from Dynamic Heart Imaging Sequence (2006)

Major heart diseases such as ischemia and hypertrophic myocardiopathy are accompanied with significant changes in the passive mechanical properties and active contractility of myocardium. Identification of these changes helps diagnose heart diseases, monitor therapy, and design surgery. A dynamic cardiac elastography (DCE) framework is developed to assess the anisotropic viscoelastic passive properties and active contractility of myocardial tissues, based on the chamber pressure and dynamic displacement measured with cardiac imaging techniques. A dynamic adjoint method is derived to enhance the numerical efficiency and stability of DCE. Model-based simulations are conducted using a numerical left ventricle (LV) phantom with an ischemic region. The passive material parameters of normal and ischemic tissues are identified during LV rapid/reduced filling and artery contraction, and those of active contractility are quantified during isovolumetric contraction and rapid/reduced ejection. It is found that quasistatic simplification in the previous cardiac elastography studies may yield inaccurate material parameters.
TOP LINAC design; Progetto del TOP LINAC (1997)

The report describes a linear accelerator for protons named TOP LINAC designed for the TOP (Terapia Oncologica con Protoni, Oncological Protontherapy) project launched by the Italian National Institute of Health (Istituto Superiore di Sanita`, ISS) to explore in collaboration with the biggest Oncological Hospital in Rome (Istituto Regina Elena, IRE) the potentialities of the therapy with accelerated protons and establish guide lines for the application of this new type of radiotherapy in comparison with the more traditional electron and x-rays radiotherapy. The concept of a compact accelerator for protontherapy applications bore within the Italian Hadrontherapy Collaboration (TERA Collaboration) with the aim to diffuse the protontherapy on the National territory. The ISS program plans to use the TOP linac proton beam also for production of PET (Positron Emission Tomography) radioisotopes and radiobiology studies. Official agreements are in course between ISS and ENEA which provides its experience in the industrial and medical accelerators for the design and the construction of the TOP linac. The accelerator that will be the first 3 GHz proton linac in the world, will be composed of a 428.3 MHz 7 Me V RFQ + DTL injector followed by a 7-65 Me V section of a 3 GHz SCDTL structure and a 65 - 200 Me V variable energy SCL 3 GHz structure. In particular the SCDTL section uses a highly innovative accelerating structure patented by ENEA. In this report the clinical and physical requests are discussed and a preliminary design of the whole machine is given.
Patient‐specific quantification of image quality: An automated method for measuring spatial resolution in clinical CT images (2016)

Clinically informed, patient-specific spatial resolution can be measured from clinical datasets. The method is sufficiently sensitive to reflect changes in spatial resolution due to different reconstruction parameters. The method can be applied to automatically assess the spatial resolution of patient images and quantify dependencies that may not be captured in phantom data.
Spray Visualization of Biodiesel and Diesel in a High Pressure Chamber (2014)

The present research attempted to characterize fuel spray pattern, such as spray angle, spray penetration and their mixture formation by recourse to images analysis. Diesel and biodiesel were used to investigate via a single hole injector (solinoild type) in a constant volume high-pressure chamber. In this experimental study, the spray characteristics of diesel and biodiesel fuel were comparatively evaluated. Initial conditions were ambient temperature, ambient density of 21 kg/m 3 , injection durations varied from 0.5 and 1 ms and rail pressure of 400 and 800 bar. The series of images were captured by high speed video camera with resolution of 7,500 frames per second and shutter speed of 1/10,000 sec under Schlieren photography technique. The result showed the biodiesel spray penetration was longer than that of the diesel, and spray angle of biodiesel in start injection was larger than biodiesel. From the results, it can be concluded that the higher the density and viscosity of biodiesel, the stronger the effect on the spray mixture formation.
Excel Scientific and Engineering Cookbook (2006)

Suitable for those who want to improve upon their Excel skills, this book teaches how to leverage Excel to perform both routine and complex calculations, and then visualize the results for presentation. It shows how to: use Excel and VBA in general; import data from a variety of sources; analyze data; perform calculations; and more. Given the improved analytical capabilities of Excel, scientists and engineers everywhere are using it - instead of FORTRAN - to solve problems. And why not? Excel is installed on millions of computers, features a rich set of built-in analyses tools, and includes an integrated Visual Basic for Applications (VBA) programming language. No wonder it's today's computing tool of choice. Chances are you already use Excel to perform some fairly routine calculations. Now, the "Excel Scientific and Engineering Cookbook" shows you how to leverage Excel to perform more complex calculations, too, calculations that once fell in the domain of specialized tools. It does so by putting a smorgasbord of data analysis techniques right at your fingertips. The book shows how to perform these useful tasks and others: use Excel and VBA in general; import data from a variety of sources; analyze data; perform calculations; visualize the results for interpretation and presentation; and use Excel to solve specific science and engineering problems
Supporting the testing of scientific frameworks with software product line engineering (2011)

Testing scientific software involves dealing with special challenges like missing test oracle and different possible sources of a problem. When testing scientific frameworks, additionally a large variety of mathematical algorithms and possible applications for the framework has to be handled. We propose to use concepts of software product line engineering to handle this variability.
Statistical machine translation (2008)

Statistical machine translation (SMT) treats the translation of natural language as a machine learning problem. By examining many samples of human-produced translation, SMT algorithms automatically learn how to translate. SMT has made tremendous strides in less than two decades, and new ideas are constantly introduced. This survey presents a tutorial overview of the state of the art. We describe the context of the current research and then move to a formal problem description and an overview of the main subproblems: translation modeling, parameter estimation, and decoding. Along the way, we present a taxonomy of some different approaches within these areas. We conclude with an overview of evaluation and a discussion of future directions.
Effect of siRNA-mediated Smad3 silence on proliferation and apoptosis in activated hepatic stellate cells (2011)

AIM: To investigate the effects of siRNA-mediated Smad3 silence on proliferation and apoptosis in activated hepatic stellate cells(HSCs).METHODS: HSCs-T6 cells were divided into 3 groups: blank group,negative control group and siRNA-Smad3 transfection group.The siRNA-Smad3 was transfected into HSCs-T6 cells.At different time points after transfection,cell proliferation was measured by CCK-8,cell apoptosis was detected by flow cytometry,and protein levels of P53 and Bcl-2 were determined by immunocytochemistry.RESULTS: HSCs proliferation was significantly inhibited at the time points of 24 h,48 h and 72 h after transfection.Meanwhile,the apoptosis of HSCs was significantly increased in siRNA-Smad3 transfection group(P0.01).Compared to the control cells,the protein expression of P53 was significantly increased while Bcl-2 protein was significantly decreased 48 h after transfection in siRNA-Smad3 transfection group(P0.01).CONCLUSION: The siRNA-mediated Smad3 silence significantly inhibits HSCs proliferation and induces apoptosis by up-regulating the P53 expression and down-regulating the Bcl-2 expression in HSCs.
Robust algorithm for automated microindentation measurement in Vickers hardness testing (2012)

Current algorithms for automated processing of Vickers hardness testing images are unsuitable for a broad range of images that are taken in industrial environments because such images show great variations in the Vickers indentation as well as in the specimen surface. The authors present a three-stage multiresolution template matching algorithm that shows excellent results, even for such challenging images. The capabilities of this algorithm are compared to known algorithms from the literature and results are presented. The comparison is conducted on two significant indentation image databases with 150 and 216 highly varying images. The applicability of the proposed algorithm is further illustrated by its competitive runtime performance.
Multi-Frequency Electromagnetic Stirring of Liquid Metals. (1996)

In some applications of electromgnetic stirring of metals a characteristic flow pattern is requested in the melt which requires a certain volume force distribution. The possibilities to achieve such a volume force distribution by a suitable geometry and position of the stirrer are limited. More flexibility is obtained when the stirring is performed with two or more magnetic fields traveling with different velocities in different directions. It is shown in the present paper that such a stirring can be realized with a conventional stirrer by feeding its three-phase winding with a current made up by superposition of two or more currents with different frequencies and traveling directions.
Hantavirus-Associated Acute Respiratory Failure (1993)

To the Editor: In May 1993, a new hantavirus-associated acute respiratory illness was recognized in the southwestern United States. Laboratory evidence of the infection has been confirmed in 30 pat...
GWAS on your notebook: fast semi-parallel linear and logistic regression for genome-wide association studies (2013)

We provide very fast algorithms for GWAS written in pure R code. We also show how to rearrange SNP data for fast access.
NUCLEIC ACID-REACTIVE ANTIBODIES SPECIFIC FOR NUCLEOSIDES AND NUCLEOTIDES (1972)

ABSTRACT A method is described for making anti-purine and anti-pyrimidine anti-bodies by immunization with conjugates of naturally-occurring nucleosides or nucleotides with carrier proteins. The specificities of the antisera are presented and shown to be predominantly, if not solely, for the determinant purine or pyrimidine group presented in the antigen. The antisera react with single-stranded or denatured DNA and, in the case of anti-adenosine, with RNA preparations. The antisera have been utilized in biochemical systems to inhibit the priming ability of DNA in a DNA-dependent DNA polymerase system, to detect minor bases such as 6-methyladenosine in DNA, and to detect small areas of single-strandedness in otherwise native DNA. The sera have also been shown to react with living cells, inhibiting the development of fertilized sea urchin eggs and entering and inhibiting transformed Chinese hamster lung cells without affecting normal ones. They have been used in immunofluorescence experiments in which they have been shown to react with nuclear DNA of fixed mouse L-cells harvested during the S phase. Moreover, they have found application in the characterization and identification of human and mouse chromosomes. Finally, initial studies have shown that they can be used in highly specific radioimmunoassays for purine and pyrimidine nucleosides.
A catalytic multistage fixed-bed tower bioreactor in an industrial-scale pilot plant for alcohol production (1996)

This article describes the development of an industrial-scale, multistage fixed-bed tower (MFBT) bioreactor using the promoter mineral kissiris for industrial alcohol production using free cells. Specifically, we examined the parameters needed to maintain operational stability from batch to batch for long periods. Pilot plant operations used one- and two-stage fixed-bed, 7000-L bioreactors. Likewise a 100,000-L, multistage fixed-bed tower system containing layered kissiris confirmed the laboratory results. Compared with a continuous stirred tank fermentor (CSTF) with recycle, a 30% reduction of energy demand and 10%-20% of the production costs are obtained. The latter are attributed to the increased ethanol concentration and alcohol productivity. (c) 1996 John Wiley & Sons, Inc.
Structure of Cerebral Arterioles in Mice Deficient in Expression of the Gene for Endothelial Nitric Oxide Synthase (2004)

We examined effects of pharmacological inhibition of nitric oxide synthase (NOS) and genetic deficiency of the endothelial isoform of NOS (eNOS) on structure and mechanics of cerebral arterioles. We measured pressure, diameter, and cross-sectional area (CSA) of the vessel wall (histologically) in maximally dilated cerebral arterioles in mice that were untreated or treated for 3 months with the NOS inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME; 10 mg/kg per day in drinking water). Treatment with L-NAME increased systemic arterial mean pressure (SAP; 143+/-4 versus 121+/-4 mm Hg, P<0.05) and CSA (437+/-27 versus 310+/-34 microm2, P<0.05). These findings suggest that hypertension induced in mice by NOS inhibition is accompanied by hypertrophy of cerebral arterioles. To determine the role of the eNOS isoform in regulation of cerebral vascular growth, we examined mice with targeted disruption of one (heterozygous) or both (homozygous) genes encoding eNOS. Wild-type littermates served as controls. SAP and CSA were significantly increased in homozygous (SAP, 141+/-5 versus 122+/-3 mm Hg in wild-type mice, P<0.05; CSA, 410+/-18 versus 306+/-15 microm2 in wild-type mice, P<0.05), but not in heterozygous (SAP, 135+/-4 mm Hg; CSA, 316+/-32 microm2) eNOS-deficient mice. Carotid ligation normalized cerebral arteriolar pulse pressure did not prevent increases in CSA in homozygous eNOS-deficient mice. Thus, cerebral arterioles undergo hypertrophy in homozygous eNOS-deficient mice, even in the absence of increases in arteriolar pulse pressure. These findings suggest that eNOS plays a major role in regulation of cerebral vascular growth.
Paclitaxel-induced cardiotoxicity. An ultrastructural study. (1996)

The ultrastructural appearance of the myocardium in a fatal case of paclitaxel-induced cardiotoxicity is reported, which includes swelling of the sarcoplasmic reticulum, loss of myofibrils, and accumulation of lipofuscin as well as laminated myelinoid figures. Such changes are very similar to those seen in anthracycline-induced cardiotoxicity and may suggest a pathogenetic final common pathway. While endomyocardial biopsy is a recognized means of monitoring anthracycline-induced cardiotoxicity, whether more liberal use of endomyocardial biopsy can prevent fatal cases of paclitaxel-induced cardiotoxicity needs to be further assessed.
<title>Numerical calculation of MTF for image motion: experimental verification</title> (1992)

A method of calculating numerically the optical transfer function appropriate to any type of image motion and vibration, including random ones, has been developed. Here the numerical calculation method is compared to experimental measurement, and the close agreement justifies implementation in image restoration for blurring deriving from any type of image motion. In addition, statistics regarding limiting resolution as a function of relative exposure time for low frequency vibrations involving random blur are described. This can be implemented in target acquisition probabilities.
Effect of eight prostaglandins on platelet aggregation (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of eight prostaglandins on platelet aggregationN. Chandra SekharCite this: J. Med. Chem. 1970, 13, 1, 39–44Publication Date (Print):January 1, 1970Publication History Published online1 May 2002Published inissue 1 January 1970https://pubs.acs.org/doi/10.1021/jm00295a011https://doi.org/10.1021/jm00295a011research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Investigation of a Novel Series of 2-Hydroxyisoquinoline-1,3(2<i>H</i>,4<i>H</i>)-diones as Human Immunodeficiency Virus Type 1 Integrase Inhibitors (2014)

We report herein further insight into the biological activities displayed by a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs). Substitution of the N-hydroxyimide two-metal binding pharmacophore at position 4 by carboxamido side chains was previously shown by us to be fruitful for this scaffold, since strong human immunodeficiency virus type 1 integrase (HIV-1 IN) inhibitors in the low nanomolar range associated with low micromolar anti-HIV activities were obtained. We investigated the influence of substitution at position 7 on biological activity. Introduction of electron-withdrawing functional groups such as the nitro moiety at position 7 led to a noticeable improvement of antiviral activity, down to low nanomolar anti-HIV potencies, with advantageous therapeutic indexes going close to those of the clinically used raltegravir and retained potencies against a panel of IN mutants.
Detecting Vehicle Anomaly by Sensor Consistency: An Edge Computing Based Mechanism (2018)

Autonomous vehicles are expected to be a disruptive technology that has the potential to revolutionize the human mobility. However, the recent research progress on intra-vehicle network (e.g., the revealing of a series of security vulnerabilities of CAN design) has demonstrated that the security issue still represents one of the major challenges of future self-driving cars. In this study, we propose a novel edge based anomaly detection system, coined VeAnDe, which exploits edge based sensor data fusion to identify the anomaly events. VeAnDe analyzes pair-wise correlations between different intra-vehicle sensors, and utilizes these correlations to examine whether an anomaly has occurred within the vehicle. More specifically, the pair-wise correlations are organized as ring architecture to reduce the computation overhead. Furthermore, the major components of VeAnDe are embedded in edge computing devices, which enables VeAnDe to be more efficient and privacy-preserving. We evaluate the performance of VeAnDe under different scenarios, and our experimental results demonstrate its feasibility and efficiency.