gebhart/patrepeval huggingface dataset:
Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro (2014)

Wild lowbush blueberries (Vaccinium angustifolium Ait) are a rich source of anthocyanins and other flavonoids with anti-inflammatory activities; however, their individual effects on cellular signaling remain to be elucidated. This study determined the capacity of blueberry bioactives to protect murine RAW 264.7 macrophages from lipopolysaccharide-induced inflammation. Fractionation of the crude extract (CE) into polyphenol-rich (PPR), anthocyanin-rich (ANC), and proanthocyanidin-rich (PAC) fractions and an ethyl acetate fraction (EA) revealed that PPR, ANC, and PAC components most effectively suppressed mRNA biomarkers of acute inflammation (Cox-2, iNOS, and IL-1β). Among major polyphenols found in the wild blueberries, malvidin-3-glucoside was significantly more effective than epicatechin or chlorogenic acid in reducing the expression of pro-inflammatory genes in vitro.
A PHASE I STUDY OF SWAINSONINE IN PATIENTS WITH ADVANCED MALIGNANCIES (1993)

Journal of Immunotherapy with Emphasis on Tumor Immunology: November 1993 - Volume 14 - Issue 4 - p 366
Latin for Dummies (2002)

Introduction Part I: Getting Started Chapter 1: You Already Know a Little Latin Chapter 2: The Nitty Gritty: Basic Latin Grammar Chapter 3: Salve! Hello! Greetings and Introductions Part II: Latin in Action Chapter 4: The Roman Family and Social Structure Chapter 5: Food and Housing in Roman Life Chapter 6: The Roman Calendar Chapter 7: The Roman Army Chapter 8: Roman Entertainment and Sports Chapter 9: Roman Government Chapter 10: More Lasting Than Bronze: Latin Literature Part III: Latin in the Modern World Chapter 11: Latin in Law Chapter 12: Latin in Medicine Chapter 13: Latin in the Church Chapter 14: Latin in Zoology and Botany Chapter 15: Translating and Reading Latin Chapter 16: Mottoes, Sayings, and Quotes: Cocktail Party Latin Part IV: The Part of Tens Chapter 17: Ten Loanwords from Latin Chapter 18: Ten False Friends: Common Mistakes in Latin Chapter 19: Ten Helpful Latin-Related Web Sites Chapter 20: Ten Common Latin Abbreviations Chapter 21: Ten Common Latin Prefixes Chapter 22: Ten Important Latin Suffixes Part V: Appendixes Appendix A: Verb and Noun Tables Appendix B: Mini-Dictionary Appendix C: Fun & Games Answers Index.
Outer-Loop Control Design and Simulation Handling Qualities Assessment for a Coaxial-Compound Helicopter and Tiltrotor (2020)

This paper describes the development of full flight envelope dynamic inversion outer-loop control laws used to control airspeed and flight path for two Future Vertical Lift-relevant rotorcraft configurations - a lift offset coaxial helicopter with a pusher propeller and a tiltrotor. The outer-loop control laws for both aircraft include a control allocation scheme to account for redundant controls and reduce pilot workload. A piloted simulation experiment was conducted at the Penn State Flight Simulator facility using a series of high-speed handling qualities demonstration maneuvers to evaluate the handling qualities of the control laws. Overall, the outer-loop control laws for both coaxial-pusher and tiltrotor aircraft were assigned Level 1 handling qualities for the Break Turn and High-Speed Acceleration/Deceleration tasks, and reduced pilot workload over previously developed inner-loop control laws. The outer-loop control laws also improved performance and reduced pilot workload in a formation flying task developed for this experiment. The coaxial-pusher outer-loop control laws received borderline Level 1/Level 2 ratings for the Pitch Attitude Capture and Hold and Sum-of-Sines Tracking tasks, while the tiltrotor outer-loop control laws (with their increased value of pitch attitude dropback) received Level 2 ratings.
Thermal conductivity of polymer nanocomposites made with carbon nanofibers (2008)

Abstract An internal mixer was used to prepare polycarbonate (PC)‐based nanocomposites containing carbon fibers, carbon nanofibers (CNF), and mixtures of the two fillers. The influence of the filler volume fraction, the relative amounts of the two fillers, and the filler orientation relative to the direction of heat flow on the thermal conductivity was examined. Filler orientation was obtained by the extrusion of strands of the nanocomposite. The thermal conductivity was measured using a steady‐state heat conduction technique. The CNF were fragile, and their aspect ratio could be decreased during processing. In general, the composite thermal conductivity increased with increasing filler content. Fiber alignment in the heat flux direction resulted in a significant increase in thermal conductivity. Mixing of nanofibers with microfibers resulted contacts between the microfibers. This, together with fiber alignment provided large increases in the thermal conductivity. POLYM. ENG. SCI., 2008. © 2008 Society of Plastics Engineers
Characterization of Guanoxabenz Reducing Activity in Rat Brain (1998)

Guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) and guanabenz (1-(2,6-dichlorobenzylidene-amino)-3-guanidine) are both known as centrally active antihypertensive drugs. We have previously shown that enzymatic activity in the rat spleen can induce N-reduction of guanoxabenz, leading to high affinity alpha 2-adrenoceptor binding, due to the formation of the alpha 2-adrenoceptor active drug, guanabenz. The spleen activity appears to reside in xanthine oxidase as it is activated by xanthine and blocked by allopurinol. We report that high affinity guanoxabenz binding is also induced in rat brain membranes after addition of NADH or NADPH cofactors. However, the brain process was clearly different from that of the spleen, as the formation of high affinity binding in the brain was not blocked by allopurinol. Moreover the NADH/NADPH activated mechanism of the brain membranes was not blocked by carbon monoxide and SKF525A, thus the activity appears not to reside in cytochrome P450 enzymes. Instead the activity was blocked by menadione and dicumarol. We conclude that the rat cerebral cortex contains an enzymatic activity that may activate guanoxabenz leading to formation of a metabolite showing high affinity for alpha 2-adrenoceptors. We also conclude that the rat brain activity is clearly distinct from that of the rat spleen.
Axial Flux Permanent Magnet Generator Design for Low Cost Manufacturing of Small Wind Turbines (2012)

In this paper the design and manufacturing processes for coreless axial flux permanent magnet generators are described for low cost rural electrification applications, where local production of small wind turbines is considered. The process is based on already existing open source design and construction manuals, while a systematic approach to designing generators of varying nominal power and for grid connection or direct battery charging schemes is described. The manufacturing process of a 3 kW small wind turbine generator for grid connection is used as a case study. Emphasis is given to the use of simple tools and techniques to achieve a lower cost, while intricate steps in the manufacturing process are described in more detail. The generator design is simulated and the constructed machine is tested in the laboratory.
Antitumor Cannabinoid Chemotypes: Structural Insights (2019)

Cannabis has long been known to limit or prevent nausea and vomiting, lack of appetite, and pain. For this reason, cannabinoids have been successfully used in the treatment of some of the unwanted side effects caused by cancer chemotherapy. Besides their palliative effects, research from the past two decades has demonstrated their promising potential as antitumor agents in a wide variety of tumors. Cannabinoids of endogenous, phytogenic, and synthetic nature have been shown to impact the proliferation of cancer through the modulation of different proteins involved in the endocannabinoid system such as the G protein-coupled receptors CB1, CB2, and GRP55, the ionotropic receptor TRPV1, or the fatty acid amide hydrolase (FAAH). In this article, we aim to structurally classify the antitumor cannabinoid chemotypes described so far according to their targets and types of cancer. In a drug discovery approach, their <i>in silico</i> pharmacokinetic profile has been evaluated in order to identify appropriate drug-like profiles, which should be taken into account for further progress toward the clinic. This analysis may provide structural insights into the selection of specific cannabinoid scaffolds for the development of antitumor drugs for the treatment of particular types of cancer.
Associating Moving Objects Across Non-overlapping Cameras: A Query-by-Example Approach (2008)

In this paper we present a query by example approach for tracking people across non overlapping cameras. The method proposed is based on the use of a multi-dimensional feature vector and its covariance, defining an appearance model of every detected moving region in the network of cameras. The model uses relative pixel position, color and gradients descriptors of each detected object. Association of objects across non-overlapping cameras is performed by matching appearance of selected object with past observations. Availability of tracking within every camera can further improve the accuracy of such association by matching several targets appearance models with detected regions. For this purpose we present an automatic clustering technique allowing to build a multi-valued appearance model from a collection of covariance matrices. The proposed approach does not require geometric or colorimetric calibration of the cameras. We will illustrate the method for tracking people and objects in relatively crowded indoor scenes.
A Hybrid GPU Rendering Pipeline for Alias-Free Hard Shadows (2009)

We present a new GPU pipeline for rendering per-pixel exact shadows that are cast by point lights and parallel lights. Our approach is hybrid in that it uses kD-tree accelerated ray-tracing to determine shadow-ray intersections, and rasterization to effectively reduce both the number of shadow rays to be traversed and the number of sub-spaces to be considered along each of these rays. To achieve this we introduce conservative shadow maps, which store a conservative estimate of the first intersection with the scene for each possible shadow ray. A novel approach to build such a map is presented, which uses rasterization to compute for every shadow-map pixel the triangles intersecting this pixel. By exploiting the rasterization capacities of recent GPUs in combination with accurate ray-triangle intersection tests, we are able to efficiently compute alias-free shadows in high-resolution and spatially extended scenes where classical shadow mapping techniques have severe difficulties.
Amphotericin B Delays the Incubation Period of Scrapie in Intracerebrally Inoculated Hamsters (1987)

The scrapie-infected hamster has been considered an excellent model for the study of slow virus diseases of man (Creutzfeldt-Jakob disease) and animals. At the moment no therapy is available for the cure of these fatal central nervous system diseases, although several drugs have been tested. We found that amphotericin B (AmB), a polyene antibiotic, increased the incubation time of scrapie disease in animals infected by either the intraperitoneal or intracerebral route. Hamsters inoculated with a 10% brain suspension of the 263K strain of scrapie showed clinical signs of disease in 54.6 +/- 4.7 days. Under AmB treatment (1 mg/kg for 6 days a week) the incubation time increased with the length of treatment, up to a maximum delay of 45 days. AmB may interact with the scrapie agent on cell plasma membranes and may thereby decrease the rate of scrapie replication. However, AmB did not have any effect when administered after the clinical onset of scrapie disease.
Quasi-Random Number Sequences from a Long-Period TLP Generator with Remarks on Application to Cryptography (1979)

The background of the Lehmer hnear congruential algorithms that are in almost universal use for random sequence generatmn is reviewed; the reasomng is given for choosing the somewhat different Tausworthe linear recurrence (mod 2) type, using the bit selection algorithm of Lewis and Payne; and the initial statmtical evaluation is reported on. A review is gwen of the intmtwe process by which the Tausworthe approach, with a generating primitive trinomial of Mersenne prime exponent degree, was chosen. A discussmn is provided on the criteria on which conventional statistmal test methods are based. Then a summary of the statmtical tests on short subsequences of one generator of this type is given. It is proved that such a generator, cycling from a nonsingular seed matrix, yields a uniform dmtnbution of values over an enttre period. Finally, perturbation procedures for inhibiting sequence extrapolation and for making sequence members nonreproducible are outhned
肌肉猛男2010 Harley-Davidson VRSCF V-Rod Muscle (2010)

VRSC家族的V代表V形双缸，R代表比赛，S代表公路，C代表定制风格。正如名称所示，哈雷大家庭中VRSC家族显得另类，不仅造型有别于经典的美式巡航车，而且在结构和性能方面都超越了同辈。让人兴奋的是，VRSC家族冷峻的造型不能遮掩热情似火的动力，最显著的就是以水冷V形双缸，打破了哈雷风冷V形双缸的传统，在同辈兄弟中具有最强的动力性能。如果你既是哈雷“粉丝”，又是动力分子，那么VRSC是你不二的选择!
101-Stage 2 µm gate ring oscillators in laser-grown silicon islands embedded in SiO<sub>2</sub> (1982)

E/D MOS test transistors and 101-stage 2 µm gate E/D MOS ring oscillators were fabricated in laser-grown single- and multicrystal islands embedded in oxide substrates. Most transistors showed good <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I-V</tex> characteristics, short-channel effects, and kink effects. Ring oscillators had a switching delay per stage (τ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Pd</inf> ) of 0.4 ns and a power-delay product (τ <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">_{Pd} \middot P_{d}</tex> ) of 2.5 PJ at a supply voltage (V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</inf> ) of 10-15 V. It was noted that different crystal orientations of the islands posed no difficulty in processing and V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> control when applied to short channel devices, and that enhanced boundary diffusion results in occasional malfunctional transistors and erroneous high surface electron mobilities (µ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">se</inf> ).
The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A. (1987)

Extracts ofEscherichia coli contain an enzyme that generates the B,l+S linkage of lipid A from fattyacylated monosaccharide precursors, according to the reaction: 2,3-diacyl-GlcN-1-P + UDP-2,3-diacyl-GlcN + 2,3-diacyl-GlcN(~,1+6)2,3-diacyl-GlcN-l-P + UDP (Ray, B. L., Painter, G., and
Crystallization of butyrate kinase 2 from<i>Thermotoga maritima</i>mediated by vapor diffusion of acetic acid (2003)

The sitting-drop method of crystallization uses the evaporation of water to increase the concentration of the protein and precipitant in the drop. The presence of other volatile components, such as acetic acid, can have a marked impact on crystallization. A member of the ASKHA (acetate and sugar kinases/Hsc70/actin) superfamily of proteins, isobutyrate kinase (Buk2) from Thermotoga maritima, was expressed in Escherichia coli with six histidine residues added to the C-terminus. The purified protein was crystallized in a sitting drop with a well solution consisting of 1.7-3.0 M sodium formate, with the pH of the well solution alone adjusted to 4.5 with acetic acid. Diffraction data collected at 100 K show that the crystals diffract to 3.1 A and belong to space group I422, with unit-cell parameters a = b = 198.12, c = 58.93 A. Both the crystal form and the results of dynamic light-scattering studies suggest that Buk2 is an octomer, the first to be identified in the ASKHA superfamily.
Depth map extraction from light field microscopes (2013)

The CAFADIS plenoptic camera was mounted onto a Leica M205A stereomicroscope and used as a prototype light field microscope. The ability to generate image stacks focused at different focal planes from a single plenoptic image was demonstrated. The focal stacks were used to create a composite extended focus image and depth map. The positions of the focal planes of the stack were measured experimentally and the data used to calibrate a computational model of the plane distribution. The resulting microscope images have an extended depth of field and a corresponding depth map with real distance estimates.
Time-series data mining (2012)

In almost every scientific field, measurements are performed over time. These observations lead to a collection of organized data called time series . The purpose of time-series data mining is to try to extract all meaningful knowledge from the shape of data. Even if humans have a natural capacity to perform these tasks, it remains a complex problem for computers. In this article we intend to provide a survey of the techniques applied for time-series data mining. The first part is devoted to an overview of the tasks that have captured most of the interest of researchers. Considering that in most cases, time-series task relies on the same components for implementation, we divide the literature depending on these common aspects, namely representation techniques, distance measures, and indexing methods. The study of the relevant literature has been categorized for each individual aspects. Four types of robustness could then be formalized and any kind of distance could then be classified. Finally, the study submits various research trends and avenues that can be explored in the near future. We hope that this article can provide a broad and deep understanding of the time-series data mining research field.
A Novel QCM-based Biosensor for Detection of Microorganisms Producing Hydrogen Sulfide (2008)

Abstract A novel piezoelectric quartz crystal microbalance (QCM) device with gas permeable membrane is proposed for the detection of microorganisms producing hydrogen sulfide (H2S). The detection theory is based on the adsorption of hydrogen sulfide onto the silver electrode of the piezoelectric crystal sensor, which causes a dramatic decrease in the resonant frequency of QCM. A 100 Hz frequency shift is chosen as the criteria value to judge the presence of microorganisms producing H2S. Factors affecting detection were investigated. Desiccant is of great practical importance in sensor response. This new biosensor can be a potential candidate for detecting bacteria which produce hydrogen sulfide.
Towards a Model for Inferring Trust in Heterogeneous Social Networks (2008)

People usually use trust and reputation to cope with uncertainty which exists in the nature and routines. The existing approaches for inferring trust rely on homogeneous relations. In other words, trust is just inferred by a homogeneous relation. In this paper, we present a new model for inferring trust using heterogeneous social networks; we use relation extraction to make a trust relation from the other relation such as friendship and the college relation and then introduced an algorithm to infer trust using extracted relation. In order to get higher performance, we extend relation extraction problem by proposing a genetic algorithm. This algorithm is more scalable, interpretable and extensible in comparison with prior ones. We also present a new algorithm for inferring trust in a social network. Using these methods, we conclude higher accuracy for trust values. Our claims are evaluated by experimental results.
Electrically Conductive Polymer Grafts Prepared by Electrochemical Polymerization of Pyrrole onto Poly[(methyl methacrylate)-co-(2-(N-pyrrolyl) Ethyl Methacrylate)] Electrodes (1998)

Pyrrole was grafted on poly[(methyl methacrylate)-co-(2-(N-pyrrolyl) ethyl methacrylate)] (PMMA-co-PEMA) using constant potential electrolyses. The thermal stability of PMMA-co-PEMA was improved as a result of electrochemical grafting with pyrrole. The electrochemical behavior of the films was studied by cyclic voltammetry. Pyrrole was found to be electroactive on PMMA-co-PEMA electrodes.
Data Transfer Matters for GPU Computing (2013)

Graphics processing units (GPUs) embrace many-core compute devices where massively parallel compute threads are offloaded from CPUs. This heterogeneous nature of GPU computing raises non-trivial data transfer problems especially against latency-critical real-time systems. However even the basic characteristics of data transfers associated with GPU computing are not well studied in the literature. In this paper, we investigate and characterize currently-achievable data transfer methods of cutting-edge GPU technology. We implement these methods using open-source software to compare their performance and latency for real-world systems. Our experimental results show that the hardware-assisted direct memory access (DMA) and the I/O read-and-write access methods are usually the most effective, while on-chip micro controllers inside the GPU are useful in terms of reducing the data transfer latency for concurrent multiple data streams. We also disclose that CPU priorities can protect the performance of GPU data transfers.
RTL Scan Design for Skewed-Load At-Speed Test under Power Constraints (2006)

This paper discusses an automated method to build scan chains at the register-transfer level (RTL) for power-constrained at-speed testing. By analyzing a circuit at the RTL, where design complexity is lower than at the gate netlist level, one can divide a circuit into multiple partitions, which can be tested independently in order to reduce test power. Despite activating one partition at a time, we show how through conscious construction of scan chains, high transition fault coverage can be achieved, while reducing test time of the circuit when employing third party test generation tools. Furthermore, as shown in experimental results, by constructing scan chains for the partitioned circuit at the RTL, area and performance penalty of the design-for-test hardware may be reduced.
The genetic epidemiology of type I diabetes mellitus and autoimmune thyroid disease. Molecular interactions at the population level. (1986)

Liability to type I diabetes and autoimmune thyroid disease is familial but not monogenic. Associations of each disorder with several genetic polymorphisms suggest complex interactions in genetic liability, as do associations with aberrant immune function in patients and their unaffected relatives. Each disorder may be genetically heterogeneous, and epidemiological studies suggest that environmental influences on liability to type I diabetes are complex. Familial aggregation of these and other autoimmune endocrine disorders is observed. Genetic analyses have not taken full account of these complexities, due to limitations in data, analytical methods, or both. Evaluating interactions of influences on liability to these disorders will require comprehensive investigations in which all relevant immunological and genetic indicators of liability are assessed for patients, affected and unaffected relatives, and healthy controls. These should aim to determine the influence of allelic variation of participating molecules on normal and aberrant immune function, liability to autoimmunity, and liability to individual diseases. Such efforts would facilitate rational immunological manipulation of liability to these disorders.
Esophageal Stethoscope Amplifier (1985)

University Hospital, Boston University Medical Center, Department of Anesthesia, 75 East Newton Street Boston, MA 02118