gebhart/patrepeval huggingface dataset:
The implementation of RTU and RSU transceiver for WLL system (2002)

The implementation of RTU and RSU transceiver for Korean WLL system based on W-CDMA is presented in this paper. RTU transceiver consists of three boards; receiver, transmitter and RF controller. RSU transceiver is divided into three parts; receiver, transmitter and IF board. At the RTU receiver, the experimental measurement shows 2.86 dB of NF and 60 dB above of dynamic range in AGC locking. At the RTU transmitter, the -49.34 dBc of ACPR is attained when the output power of the transmitter is 34.3 dBm. At the RSU receiver, the measured of the NF shows 5.65 dB. The measured ACPR of the RSU transmitter is -49.33 dBc when the transmitter operates in normal state. These results are good enough to meet standard performance specifications.
Grating Coupling Between Surface Acoustic Waves and Plate Modes (1980)

Experiments are analyzed in which frequency selective coupling was observed between two gratings formed on opposite faces of a planar slab. Asurface acoustic wave (SAW) propagates along one of the gratings couples into a slab waveguide mode which in turn may be coupled out by the other grating. Because the coupling between a SAW and a waveguide mode is highly frequency selective, the transfer func- tion consists of a series of narrow spikes (passbands). A spike occurs when the propagation constant of the waveguide mode coincides with propagation constant of the Rayleigh wave shifted by f 2n/p where p is the spatial period of the grating. Whenever a transfer of power takes place between the top and bottom gratings, a dip (stopband) is observed in the signal from the output transducer mounted on top of the waveguide slab. These dips exhibit a marked asymmetry around the frequency at which the Rayleigh wavelength h, equals the grating period P. A theory is developed that explains the frequencies of the dips and the observed asymmetry.
User privacy-preserving identity data dependencies (2006)

Identity Federation technologies have enabled users to leverage their relationships with an Identity Provider (IdP) into a Service Provider's (SP) domain. They allow user-initiated and IdP-controlled sharing of authentication information, attributes and authorization policies, allowing users to get benefits like Single Sign On (SSO) and attribute linking across the different domains. Federation-based Identity Services have enabled a standardized mechanism of sharing a particular type of user identity information with interested SPs. Yet, with increasing focus on composite as well as personalized user experiences, different types of User Identity Data need to be used together. In this paper, we argue that there is a lack of standardized mechanisms for resolution and ownership, when it comes to data associations across different Identity Providers. Additionally, users have different privacy requirements for these different kinds of interacting identity information and need mechanisms to enforce them. We propose a solution which allows users to define privacy-preserving data dependencies between their different Identity information. Thus, a query for a particular user information, would honor and traverse its associated data dependencies, possibly triggering user-defined policies, to come up with a resultant set of identity information.
Calculations of Analytical Chemistry (Hamilton, Leicester F.; Simpson, Stephen G.) (1961)

ADVERTISEMENT RETURN TO ISSUEPREVBook and Media Revie...Book and Media ReviewNEXTCalculations of Analytical Chemistry (Hamilton, Leicester F.; Simpson, Stephen G.)M. G. Mellon Cite this: J. Chem. Educ. 1961, 38, 1, 49Publication Date (Print):January 1, 1961Publication History Received3 August 2009Published online1 January 1961Published inissue 1 January 1961https://doi.org/10.1021/ed038p49.2RIGHTS & PERMISSIONSArticle Views715Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (763 KB) Get e-Alerts Get e-Alerts
The Sirtuin Inhibitor Nicotinamide Enhances Neuronal Cell Survival During Acute Anoxic Injury Through AKT, BAD, PARP, and Mitochondrial Associated "Anti-Apoptotic" Pathways (2005)

Understanding the role of nicotinamide (NIC) in different cell systems represents a significant challenge in several respects. Recently, NIC has been reported to have diverse roles during cell biology. In the absence of NIC, sirtuin protein activity is enhanced and pyrazinamidase/nicotinamidase 1 (PNC1) expression, an enzyme that deaminates NIC to convert NIC into nicotinic acid, is increased to lead to lifespan extension during calorie restriction, at least in yeast. Yet, NIC may be critical for cell survival as well as the modulation of inflammatory injury during both experimental models as well as in clinical studies. We therefore investigated some of the underlying signal transduction pathways that could be critical for the determination of the neuroprotective properties of NIC. We examined neuronal injury by trypan blue exclusion, DNA fragmentation, phosphatidylserine (PS) exposure, Akt1 phosphorylation, Bad phosphorylation, mitochondrial membrane potential, caspase activity, cleavage of poly(ADP-ribose) polymerase (PARP), and mitogen-activated protein kinases (MAPKs) phosphorylation. Application of NIC (12.5 mM) significantly increased neuronal survival from 38 -/+ 3% of anoxia treated alone to 68 +/- 3%, decreased DNA fragmentation and membrane PS exposure from 67 -/+ 4% and 61 -/+ 5% of anoxia treated alone to 30 +/- 4% and 26 +/- 4% respectively. We further demonstrate that NIC functions through Akt1 activation, Bad phosphorylation, and the downstream modulation of mitochrondrial membrane potential, cytochrome c release, caspase 1, 3, and 8 - like activities, and PARP integrity to prevent genomic DNA degradation and PS externalization during anoxia. Yet, NIC does not alter the activity of either the MAPKs p38 or JNK, suggesting that protection by NIC during anoxia is independent of the p38 and JNK pathways. Additional investigations targeted to elucidate the cellular pathways responsible for the ability of NIC to modulate both lifespan extension and cytoprotection may offer critical insight for the development of new therapies for nervous system disorders.
AZD9150, a next-generation antisense oligonucleotide inhibitor of <i>STAT3</i> with early evidence of clinical activity in lymphoma and lung cancer (2015)

Next-generation sequencing technologies have greatly expanded our understanding of cancer genetics. Antisense technology is an attractive platform with the potential to translate these advances into improved cancer therapeutics, because antisense oligonucleotide (ASO) inhibitors can be designed on the basis of gene sequence information alone. Recent human clinical data have demonstrated the potent activity of systemically administered ASOs targeted to genes expressed in the liver. We describe the preclinical activity and initial clinical evaluation of a class of ASOs containing constrained ethyl modifications for targeting the gene encoding the transcription factor STAT3, a notoriously difficult protein to inhibit therapeutically. Systemic delivery of the unformulated ASO, AZD9150, decreased STAT3 expression in a broad range of preclinical cancer models and showed antitumor activity in lymphoma and lung cancer models. AZD9150 preclinical activity translated into single-agent antitumor activity in patients with highly treatment-refractory lymphoma and non-small cell lung cancer in a phase 1 dose-escalation study.
Conversations in the Blogosphere: An Analysis "From the Bottom Up" (2005)

The "blogosphere" has been claimed to be a densely interconnected conversation, with bloggers linking to other bloggers, referring to them in their entries, and posting comments on each other's blogs. Most such characterizations have privileged a subset of popular blogs, known as the 'A-list.' This study empirically investigates the extent to which, and in what patterns, blogs are interconnected, taking as its point of departure randomly-selected blogs. Quantitative social network analysis, visualization of link patterns, and qualitative analysis of references and comments in pairs of reciprocally-linked blogs show that A-list blogs are overrepresented and central in the network, although other groupings of blogs are more densely interconnected. At the same time, a majority of blogs link sparsely or not at all to other blogs in the sample, suggesting that the blogosphere is partially interconnected and sporadically conversational.
Viscoelastic Behavior of Semidilute Solutions of Multisticker Polymer Chains (1999)

Multisticker polymer chains consisting of water-soluble polyacrylamides hydrophobically modified with low amounts of N,N-dihexylacrylamide have been prepared by a free radical micellar polymerization technique. This process gives multiblock copolymers in which the number and length of the hydrophobic blocks can be tuned by varying the surfactant over hydrophobe molar ratio. The viscoelastic behavior of semidilute solutions of various series of copolymers with variable molecular weights (Mw ≈ 4.2 × 104−2.7 × 106), hydrophobe contents ([H] = 0.5−2 mol %), and hydrophobic block lengths (NH = 1−7 units per block) has been investigated as a function of polymer concentration, C, using steady-flow and oscillatory experiments. In the semidilute range, two different regimes can be clearly distinguished in the zero-shear viscosity η0 = f(C) curves: a first unentangled regime where the viscosity increase rate strongly depends on NH and [H]; a second entangled regime where the viscosity follows a scaling behavior of the polymer concentration with an exponent close to 4, whatever [H] or NH. The linear viscoelasticity can be described by (i) a slow relaxation process with a plateau modulus that only depends on polymer concentration and (ii) other faster complex relaxation processes. In the latter regime, the results can be quite well accounted for by a hindered reptation model.
High-performance DSPs (2000)

The processing delay is a serious constraint for speech communication. A one-way end-to-end delay of more than 150 ms can severely degrade the quality of real-time conversations. The components of the total system delay includes the speech frame size, the look ahead, other algorithmic delays, multiplexing delay, processing delay for computation, and transmission delay. At the transcoder rate adaptor unit (TRAU), the only delay that can be manipulated is the processing delay. The TRAUs are generally positioned remote to the base transceiver station (BTS). The channel codec units (CCUs) are located in the BTS. In general, 16 kbit/s traffic channels can be used for full rate speech between the TRAU and BTS. By putting the TRAU remote to the BTS, DSPs for speech coding can be utilized more efficiently to cut system cost. High performance DSPs, such as the Lucent DSP16000, can be used to further cut the cost per speech channel. This article presents an implementation of GSM enhanced full rate (EFR) codec on the Lucent Technologies' DSP16000. The original European Telecommunications Standards Institute (ETSI) C code has been restructured to address the issues of MIPS (million instructions per second), RAM usage, and processing delay. We give a performance overview of vocoder implementations on some existing fixed-point DSPs and discuss the architecture of the DSP16000. Details on how the ETSI C code is restructured are presented. The DSP16210 implementation results are then discussed.
Expression of COX‐2, mPGE‐synthase <sub>1</sub> , MDR‐1 (P‐gp), and Bcl‐x <sub>L</sub> : a molecular pathway of <i>H pylori</i> ‐related gastric carcinogenesis (2004)

Helicobacter pylori up-regulates cyclo-oxygenase-2 (COX-2) expression, which in turn is involved in tumourigenesis. Recently, a causal link between COX-2 and multidrug resistance 1 (MDR-1) gene expression, implicated in cancer chemoresistance, has been demonstrated. Thus, the expression of COX-2 and the downstream enzyme involved in PGE2 biosynthesis, microsomal PGE-synthase1 (mPGES1), was correlated with P-gp, the product of MDR-1, and the anti-apoptotic protein, Bcl-xL, in gastric biopsies from patients with H pylori infection and in patients with gastric cancer. In a retrospective analysis of endoscopic and pathology files, 40 H pylori-negative patients (Hp-), 50 H pylori-positive patients who responded to eradication therapy (Hp+R), 84 H pylori-positive patients who did not respond to eradication therapy (Hp+NR), and 30 patients with gastric cancer (18 intestinal and 12 diffuse types) were selected. COX-2, mPGES1, P-gp, and Bcl-xL were detected by immunohistochemistry. COX-2, mPGES1, P-gp, and Bcl-xL expression was undetectable in gastric mucosa from Hp- patients. By contrast, COX-2 and mPGES1 expression was detected in 42% and 44% of Hp+R patients, respectively, and in up to 66% (range 63-66%) of Hp+NR patients (p < 0.05). The expression of COX-2 and mPGES1 correlated significantly (p < 0.0001) with that of P-gp and Bcl-xL. High levels of COX-2, mPGES1, P-gp, and Bcl-xL expression were found in intestinal-type gastric cancer samples. In conclusion, H pylori-dependent induction of COX-2 and mPGES1 is associated with enhanced production of P-gp and Bcl-xL that may contribute to gastric tumourigenesis and resistance to therapy.
Mechanisms for the Antithrombotic Activity in Man of Low Molecular Weight Heparins (LMWHs) (1994)

Although LMWH have been widely used for several years, the mechanisms of their anti-thrombotic action are not well understood. This is due in part to the misconception that in vitro coagulation results can be extrapolated to the in vivo antithrombotic condition. Thus, the mode of action of heparins on thrombin generation in plasma after addition of increasing amounts of unfractionated heparin (UH) or LMWH has been investigated in several studies, but a distinction has to be made between the effects on the intrinsic and the extrinsic system. The same applies for experiments conducted with platelet-poor plasma (PPP) and platelet-rich plasma (PRP). These experiments show that inhibition of prothrombin activation in PPP is more pronounced in the intrinsic system than in the extrinsic system for both types of heparin. This inhibition has been attributed mainly to their antithrombin activity which reduces factor V and factor VIII activation and its related positive feedback on thrombin formation. The comparison of the effects of low doses of LMWH and UH in citrated PRP indicate that LMWH are more active than UH because they are more resistant to platelet neutralization by platelet factor 4. Moreover, in vitro study will neglect the role of pharmacokinetic parameters which are important determinants of the antithrombotic activity of heparins. Another important difference between in vitro and in vivo studies lies in the fact that sc injection of both heparins will release tissue factor pathway inhibitor (TFPI) in the blood. We have used native whole blood for in vitro and ex vivo experiments. This offers the advantage of studying heparin activity in the presence of platelets and calcium. In this condition the inhibition of pro-thrombin and factor VII activation during blood coagulation in a glass tube (intrinsic system) was judged by measuring residual prothrombin and factor VIIa in serum obtained 2 to 4 hours after clotting. At prophylactic doses, LMWHs in contrast to UH significantly inhibit prothrombin activation. Although thrombin inhibition seems essential for the antithrombotic activity of both heparins, reduction of thrombosis is a global effect to which "both anti-IIa and anti-Xa activity contribute but to a different exent" (C. Hemker et al.). It should be noted that the clearance half-life of anti-Xa activity is significantly longer than that of anti-IIa. The efficacy of a single daily injection of LMWH in the prophylaxis of thrombosis is not logical in light of the short half-life of anti-IIa activity.(ABSTRACT TRUNCATED AT 400 WORDS)
Insulin-specific suppressor T cell factors. (1986)

Murine antibody responses to heterologous insulins are controlled by MHC-linked immune response genes. Although nonresponder mice fail to make antibody when injected with nonimmunogenic variants of insulin, we have recently shown that nonimmunogenic variants stimulate radioresistant, Lyt- 1+2- helper T cells that support secondary antibody responses. However, the helper activity can not be detected unless dominant, radiosensitive Lyt-1-2+, I-J+ suppressor T cells are removed. In this paper we report that extracts of primed Lyt-2+ suppressor T cells contain insulin-specific suppressor factors (TsF) that are capable of replacing the activity of suppressor T cells in vitro. The activity of these factors is restricted by MHC-linked genes that map to the I-J region, and immunoadsorption studies indicated that they bind antigen and bear I-J-encoded determinants. Insulin-specific TsF consists of at least two chains, one-bearing I-J and the other the antigen-binding site. Furthermore, mixing of isolated chains from different strains of mice indicates that the antigenic specificity is determined by the antigen-binding chain and the MHC restriction by the H-2 haplotype of the source of the non-antigen-binding, I-J+ chain. Moreover, mixtures containing antigen-binding chain from allogeneic cell donors and I-J+ chain from responder cell donors have activity in cultures containing responder lymphocytes. This suggests that preferential activation of suppressor T cells, rather than differential sensitivity to suppression, results in the nonresponder phenotype to insulin.
Speaking for the environment (1995)

Communicators have special opportunities to promote environmental ethics. This paper shows how environmental ethics relates to the workplace and gives ideas about how communicators can help the environment in their work.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Constitution and Stereochemistry of Samogenin, Markogenin and Mexogenin<sup>1</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConstitution and Stereochemistry of Samogenin, Markogenin and Mexogenin1Carl Djerassi and Jack FishmanCite this: J. Am. Chem. Soc. 1955, 77, 16, 4291–4297Publication Date (Print):August 1, 1955Publication History Published online1 May 2002Published inissue 1 August 1955https://pubs.acs.org/doi/10.1021/ja01621a036https://doi.org/10.1021/ja01621a036research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High Rotational Speeds in Vacuum (1941)

Rotors freely suspended in high vacuum were driven to high rotational speeds by electrostatic and by electromagnetic forces. The first suspension used was a modification of the photoelectrically stabilized suspension developed in this laboratory by F. T. Holmes. Another magnetic suspension was developed which was stabilized by capacity coupling. The electrostatic drive consisted of a charged bisymmetrical blade free to rotate between quadrant plates to which were applied alternating potentials generated either by interruption of a beam of light by the rotor, by capacity pick-up, or by an external oscillator. Rotors were also driven by rotating magnetic fields. Objects suspended varied in weight from 7 g to 1200 g. The highest speed attained was 3200 r.p.s. using a 14-g rotor. A deceleration of 2.2×10−4 rev./sec.2 was measured with a 47-g rotor (moment of inertia, 103 g cm2) running at 650 r.p.s. with no applied torque.
[Kinetic models for the effect of temperature on batch glutathione fermentation by Candida utilis]. (2003)

Glutathione (L-gamma-glutamyl-L-cysteinylglycine), one of the major non-protein thiol compounds, is widely distributed in living cells and plays an important role in maintaining the normal redox environment of cells as an antioxidant. In the production of glutathione by fermentation, temperature is one of the most important environmental factors that affect the yield and the productivity of glutathione. Here the effect of temperature, varied from 24 degrees C to 32 degrees C, on the batch fermentation of glutathione in a 7 L stirred fermenter by Candida utilis WSH 02-08 was investigated. It was found that cell growth was hastened along with the increase of temperature. The maximum dry cell weight was achieved approximately 16 g/L under various temperatures, as soon as the glucose was exhausted. The effect of temperature on glutathione production was different from that on cell growth: the lower the temperature, the higher the glutathione production, i.e. the maximum glutathione concentration at 32 degrees C (235 mg/L) was only 75% and 64% of that at 30 degrees C and 26 degrees C, respectively. The maximum average specific growth rate (0.13 h(-1)) was achieved at 30 degrees C while the maximum glutathione concentration (366 mg x L(-1)) and the maximum intracellular glutathione content (2.3%) were obtained at 26 degrees C. Therefore, the optimum temperatures for cell growth and glutathione production are quite different in the batch fermentation. A modified Logistic equation was successfully applied to estimate the kinetics of cell growth. The maximum specific growth rate and the substrate inhibition constant, calculated from this equation, were both increased along with the temperature. In addition, the glutathione fermentation by C. utilis WSH 02-08 under various temperatures was proven to be a partial growth-associated process by estimating the process with the Luedeking-Piret equation. Based on the estimated parameon the estimated parameters, the effect of temperature on the kinetics of cell growth was further studied. An equation, dX / dt = [0.0224(T + 1.7)]2 X(1-X/Xmax) / 1 + S/ {8.26 x 10(6) x exp [-31477/R/(T+273)]}, was developed and applied to interlink the relationship between biomass concentration and temperature as well as substrate concentration in the batch glutathione fermentation. The experiment results showed that this model could predict the growth pattern very well.
Expression of cell cycle-related genes in dying cells in retinal ischemic injury. (1998)

Aberrant expression of cell cycle-related genes may play an important role in the cell death that accompanies retinal ischemia-reperfusion injury.