gebhart/patrepeval huggingface dataset:
Precipitation polymerization for fabrication of complex core–shell hybrid particles and hollow structures (2013)

Functional polymer micro- and nanoparticles with novel morphology are of great importance because of their wide range of applications in complex biological systems and nanotechnology. Due to the outstanding advantage of the absence of any surfactant, precipitation polymerization as a heterogeneous polymerization technique has been developed to prepare various uniform and clean polymer particles, such as microspheres, nanoparticles, core-shell particles, core-double shell particles, single-shell hollow particles, double-shell hollow particles, and rattle-type hollow nanostructures. In this review, a general introduction into the categories of precipitation polymerization and their mechanisms is presented. The precise control of particle size, size distribution, pore size, morphology and surface chemistry of micro- and nanoparticles, core-shell hybrids and polymer hollow structures is discussed. The development of complex nanostructures and their applications in separation, drug delivery and nano-reactor systems are highlighted as well.
Absolute distance measurement by dual-comb nonlinear asynchronous optical sampling (2014)

A dual-comb nonlinear asynchronous optical sampling method is proposed to simplify determination of the time interval and extend the non-ambiguity range in absolute length measurements. Type II second harmonic generation facilitates curve fitting in determining the time interval between adjacent pulses. Meanwhile, the non-ambiguity range is extended by adjusting the repetition rate of the signal laser. The performance of the proposed method is compared with a heterodyne interferometer. Results show that the system achieves a maximum residual of 100.6 nm and an uncertainty of 1.48 μm in a 0.5 ms acquisition time. With longer acquisition time, the uncertainty can be reduced to 166.6 nm for 50 ms and 82.9 nm for 500 ms. Moreover, the extension of the non-ambiguity range is demonstrated by measuring an absolute distance beyond the inherent range determined by the fixed repetition rate.
Equivalent Circuits of a Linear Time-Invariant Two-Port in Terms of the Transmission Parameters/Inverse Transmission Parameters and Nullator-Norator Representations (2001)

Equivalent circuits of a linear time-invariant two-port in terms of the z-parameters, they-parameters, the hybrid parameters and the inverse hybrid parameters have been shown in the most of the textbooks for a long time. Meanwhile, the transmission parameters and the inverse transmission parameters are used very commonly in dealing with a cascade connection of two-ports. In network synthesis, transmission parameters and inverse transmission parameters are also considered sometimes. However, the equivalent circuits of a linear time-invariant two-port in terms of the transmission parameters and the inverse transmission parameters are still missing. In this paper, these two equivalent circuits with nullator-norator representations are proposed.
High-Dose Fenretinide in Oral Leukoplakia (2009)

We previously showed that low-dose fenretinide (200 mg/d) had limited activity in retinoid-resistant oral leukoplakia (34% response rate) possibly because serum drug levels were insufficient to induce retinoid receptor-independent apoptosis. Therefore, we designed the single-arm phase II trial reported here to investigate whether higher-dose fenretinide would improve leukoplakia response over that of our previous study. Leukoplakia patients received fenretinide (900 mg/m(2) twice daily) in four 3-week cycles (1 week on drug followed by 2 weeks off). At week 12, clinical responses were determined and blood samples were collected for serum drug level assessments. A planned interim futility analysis led to early trial closure after the initial 15 (of 25 planned) patients because only 3 (20%) had a partial response (stopping rule: <or=4 responses in first 16 patients). Fenretinide was well tolerated--only one grade 3 adverse event (diarrhea) occurred. Serum fenretinide levels changed from 0 (baseline) to 0.122 +/- 0.093 micromol/L (week 12). In correlative in vitro studies, high-dose fenretinide inhibited the growth of head and neck cancer cells more and oral leukoplakia cells less than did lower doses of fenretinide. This result is consistent with our clinical finding that high-dose fenretinide did not improve on the historical response rate of lower-dose fenretinide in our previous oral leukoplakia trial.
A Meta-Analysis on the Interaction between HER-2 Expression and Response to Endocrine Treatment in Advanced Breast Cancer (2005)

HER-2-positive metastatic breast cancer is less responsive to any type of endocrine treatment. This effect holds in the subgroup of patients with positive or unknown steroid receptors.
The stability of lisinopril as an extemporaneous syrup. (2015)

The stability of lisinopril as an extemporaneous syrup compounded from powder was studied. The lisinopril syrup (2mg/mL) was prepared by incorporating lisinopril powder dissolved in water into simple syrup. Samples of the syrup were stored in amber-colored plastic bottles at 5 and 23 deg C. At various times during the 30-day study period, the concentration of lisinopril waas determined by a stability-indicating high performance liquid chromatography assay procedure. Samples were also visually inspeceted for color and clarity. Over the 30-day study period, the percentage of the initial concentration remained between 97.46% and 100.54% for the 23 deg C samples and 98.15% and 100.74% for the 5 deg C samples.
Butyrate Promotes Induced Pluripotent Stem Cell Generation (2010)

Recent studies have demonstrated that embryonic stem cell-like induced pluripotent stem (iPS) cells can be generated by enforced expression of defined transcription factors. The fact that cell fate change is accompanied by changes in epigenetic modifications prompted us to investigate whether chemicals known to modulate epigenetic regulators are capable of enhancing the efficiency of iPS cell generation. Here, we report that butyrate, a natural small fatty acid and histone deacetylase inhibitor, significantly increases the efficiency of mouse iPS cell generation using the transcription factors Oct4, Sox2, Klf4, and c-Myc. We show that butyrate not only changes the reprogramming dynamics, but also increases the ratio of iPS cell colonies to total colonies by reducing the frequency of partially reprogrammed cells and transformed cells. Detailed analysis reveals that the effect of butyrate on reprogramming appears to be mediated by c-Myc and occurs during an early stage of reprogramming. Genome-wide gene expression analysis reveals up-regulation of ES cell-enriched genes when mouse embryonic fibroblasts are treated with butyrate during reprogramming. Thus, our study identifies butyrate as a chemical factor capable of promoting iPS cell generation.
An Infrared Flame Detector With Fire-Ranging Ability (1987)

Many infrared flame detectors are now available which detect the presence of a flame by sensing radiation at or near 4.3 microns in the middle infrared. However, the radiation spectrum produced in this wavelength band, largely due to the hot carbon dioxide produced in the flame, is modified in transmission through the atmosphere from the flame to the detector. A study of these changes has shown that they can be used to gauge the distance of the flame from the detector. Some preliminary results from a detector built to provide this type of information are reported and the advantages that the technique can provide in terms of fire detection systems are also considered.
Design Development of High Temperature Manifold Converter Using Thin Wall Ceramic Substrate (1997)

<div class="htmlview paragraph">This paper proposes a high temperature manifold converter with a thin wall ceramic substrate, such as; 4mil/400cpsi and 4mil/600cpsi. Double-wall cone insulation design was proposed for close-coupled converters to protect the conventional intumescent mat from high temperature. However, the double wall cone insulation is not applicable when the converter is directly mounted to the exhaust manifold without an inlet cone. The prototype manifold converter was tested under hot vibration test with a non-intumescent ceramic fiber mat and retainer rings as a supplemental support. The converter demonstrated durability for 10 hours under 80G acceleration and 100 hours under 60G acceleration with 1,050 °C catalyst bed temperature. The skin temperature of the heat shield was kept below 400 °C.</div>
The software radio architecture (1995)

As communications technology continues its rapid transition from analog to digital, more functions of contemporary radio systems are implemented in software, leading toward the software radio. This article provides a tutorial review of software radio architectures and technology, highlighting benefits, pitfalls, and lessons learned. This includes a closer look at the canonical functional partitioning of channel coding into antenna, RF, IF, baseband, and bitstream segments. A more detailed look at the estimation of demand for critical resources is key. This leads to a discussion of affordable hardware configurations, the mapping of functions to component hardware, and related software tools. This article then concludes with a brief treatment of the economics and likely future directions of software radio technology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Degradation of cartilage matrix proteoglycan by human neutrophils involves both elastase and cathepsin G (1991)

The granule proteases of human neutrophils are thought to be responsible for the connective tissue destruction associated with certain inflammatory diseases. Using a model system for the degradation of a macromolecular connective tissue substrate, purified neutrophil elastase and cathepsin G were both individually able to degrade cartilage matrix proteoglycan and this degradation was blocked by the appropriate specific inhibitors. Neutrophil granule lysate also produced cartilage matrix degradation but little inhibition of degradation occurred when either elastase or cathepsin G inhibitor was used alone. However, a combination of elastase and cathepsin G inhibitors each at 100 microM or each at 10 microM blocked cartilage matrix degradation by 89% +/- 1 and 65% +/- 9 (mean +/- SEM, n = 3), respectively. The magnitude of the cartilage degradation mediated by neutrophil lysate, and its sensitivity to specific inhibitors, was reproduced using purified elastase and cathepsin G at the concentrations at which they are present in neutrophil lysate. Human neutrophils stimulated with opsonized zymosan degraded cartilage matrix in a dose-dependent manner in the presence of serum antiproteases. Supernatants from stimulated neutrophils cultured in the presence of serum did not degrade cartilage matrix, indicating that neutrophil mediated degradation in the presence of serum was confined to the protected subjacent region between the inflammatory cell and the substratum. A combination of elastase and cathepsin G inhibitors each at 500 microM or each at 100 microM blocked subjacent cartilage matrix degradation by stimulated human neutrophils by 91% +/- 3 and 54% +/- 8 (mean +/- SEM, n = 5), respectively, whereas either the elastase or cathepsin G inhibitor alone was much less effective. These studies demonstrate that neutrophil-mediated cartilage matrix degradation is produced primarily by elastase and cathepsin G. Furthermore, these results support the hypothesis that inflammatory neutrophils form zones of close contact with substratum that exclude serum antiproteases and that this subjacent degradation of cartilage matrix by stimulated neutrophils can be blocked by a combination of synthetic elastase and cathepsin G inhibitors.
Two Ancient Classes of MIKC-type MADS-box Genes are Present in the Moss Physcomitrella patens (2002)

Characterization of seven MADS-box genes, termed PPM1-PPM4 and PpMADS1-PpMADS3, from the moss model species Physcomitrella patens is reported. Phylogeny reconstructions and comparison of exon-intron structures revealed that the genes described here represent two different classes of homologous, yet distinct, MIKC-type MADS-box genes, termed MIKC(c)-type genes-"(c)" stands for "classic"-(PPM1, PPM2, PpMADS1) and MIKC(*)-type genes (PPM3, PPM4, PpMADS2, PpMADS3). The two gene classes deviate from each other in a characteristic way, especially in a sequence stretch termed intervening region. MIKC(c)-type genes are abundantly present in all land plants which have been investigated in this respect, and give rise to well-known gene types such as floral meristem and organ identity genes. In contrast, LAMB1 from the clubmoss Lycopodium annotinum was identified as the only other MIKC(*)-type gene published so far. Our findings strongly suggest that the most recent common ancestor of mosses and vascular plants contained at least one MIKC(c)-type and one MIKC(*)-type gene. Our studies thus reveal an ancient duplication of an MIKC-type gene that occurred before the separation of the lineages that led to extant mosses and vascular plants more than about 450 MYA. The identification of bona fide K-domains in both MIKC(*)-type and MIKC(c)-type proteins suggests that the K-domain is more ancient than is suggested by a recent alternative hypothesis. MIKC(*)-type genes may have escaped identification in ferns and seed plants so far. It seems more likely, however, that they represent a class of genes which has been lost in the lineage which led to extant ferns and seed plants. The high number of P. patens MADS-box genes and the presence of a K-box in the coding region and of some potential binding sites for MADS-domain proteins and other transcription factors in the putative promoter regions of these genes suggest that MADS-box genes in mosses are involved in complex gene regulatory networks similar to those in flowering plants.
Electrical Properties of Prostatic Tissues: II. Spectral Admittivity Properties (2009)

Spectral electrical admittivity properties provide sufficient levels of ex vivo cancer discrimination that may potentially enhance disease localization when prostate cancer is suspected. The development of novel technologies gauging these properties in vivo has the potential to provide new tissue characterizing tools for prostate cancer detection and identification.
Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model (2013)

Although in vitro studies pointed to the tumor necrosis factor family member APRIL (a proliferation-inducing ligand) in mediating survival of chronic lymphocytic leukemia (CLL) cells, clear evidence for a role in leukemogenesis and progression in CLL is lacking. APRIL significantly prolonged in vitro survival of CD5(+)B220(dull) leukemic cells derived from the murine Eμ-TCL1-Tg (TCL1-Tg [transgenic]) model for CLL. APRIL-TCL1 double-Tg mice showed a significantly earlier onset of leukemia and disruption of splenic architecture, and survival was significantly reduced. Interestingly, clonal evolution of CD5(+)B220(dull) cells (judged by BCR clonality) did not seem to be accelerated by APRIL; both mouse strains were oligoclonal at 4 months. Although APRIL binds different receptors, APRIL-mediated leukemic cell survival depended on tumor necrosis factor receptor superfamily member 13B (TACI) ligation. These findings indicate that APRIL has an important role in CLL and that the APRIL-TACI interaction might be a selective novel therapeutic target for human CLL.
Chemical stability of amiodarone hydrochloride in intravenous fluids. (2015)

The chemical stability of amiodarone hydrochloride in two intravenous (IV) fluids, 5% dextrose injection and 0.9% sodium chloride injection, was studied. Drug degradation was monitored using a stabiility-indicating, high-performance liquid chromatography assay method. The admixtures of amiodarone in the two IV fluids were found to be stable for 32 days when refrigerated (5 deg C) , and also at room temperature (25 deg C). All solutions remained clear during this period. The recommendations from the manufacturer are conservative. The admixtures are apparently physically and chemically stable for more than 24 hours, provided they are protected from microbiological contamination. However at 40 deg C, significant degradation was observed ater 18 days; and the solutions turned cloudy. Precautions must be taken to prevent temperature elevation during storage.
A 3′ co-terminus of two early herpes simplex virus type 1 mRNAs (1982)

A 3' co-terminus of two early herpes simplex virus type 1 mRNAs has been identified using the nuclease -S1 mapping procedure with cloned virus DNA probes. These mRNAs (5.0 kb and 1.2 kb), located within the genome region 0.56-0.60, are unspliced and are transcribed rightwards on the prototype genome orientation. The position of their 3' ends has been located on the virus DNA sequence and lies downstream from the polyadenylation signal 5'-AATAAA-3'. This hexanucleotide sequence also was present in the complementary DNA strand and was shown to be the polyadenylation signal for a leftwards-transcribed late mRNA. The abundance within the cytoplasm of the 5.0 kb and 1.2 kb mRNAs was investigated. Results indicated that these mRNAs were regulated in concert. It is suggested that sequences at the 3' co-terminus may be involved in their regulation.
Performance optimization of surface acoustic wave chemical sensors (2002)

Surface acoustic wave (SAW) devices coated with a thin layer of chemoselective material provide highly sensitive chemical sensors for the detection and monitoring of vapors and gases. In this work, a variety of coating materials and coating deposition techniques have been evaluated on SAW devices. A new technique, matrix assisted pulsed laser embossing, is utilized to deposit polymer films on SAW devices, and conventional pulsed laser deposition is used to deposit a passivation layer of diamond-like-carbon on a SAW device surface. Both the electrical characteristics and the performance of the prepared devices against different gases have been determined.
Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity. (2004)

EKB-569 is an irreversible inhibitor of epidermal growth factor receptor (EGF-R) tyrosine kinase. It inhibits EGF-induced phosphorylation of EGF-R and the growth of tumors that overexpress EGF-R in animal models. In clinical trials, EKB-569 and all other EGF-R inhibitors cause skin rashes. To understand the latter phenomenon, the effect of EKB-569 on EGF-R as well as downstream signaling to phosphoinositide 3-kinase-protein kinase B (AKT), extracellular signal-regulated kinase 1 and 2 (ERK1/2), or signal transducer and activator of transcription 3 (STAT3) pathways were compared in tumor cell lines and normal human keratinocytes (NHEK) grown in tissue culture. Tumor cell lines that have high (A431 epidermoid and MDA-468 breast carcinomas) and low (MCF-7 breast carcinoma) expression of EGF-R were used. NHEK cells express at least 15-fold less EGF-R than A431 cells. EKB-569 was a potent inhibitor of proliferation in NHEK, A431, and MDA-468 cells (IC(50) = 61, 125, and 260 nM, respectively) but not MCF-7 cells (IC(50) = 3600 nM). EKB-569 was also a potent inhibitor of EGF-induced phosphorylated EGF-R (pEGF-R) in A431 and NHEK cells (IC(50) = 20-80 nM). The reduction in pEGF-R paralleled inhibition of phosphotyrosine-705 STAT3, while the inhibition of phosphorylated AKT and phosphorylated ERK1/2 occurred at higher concentrations of EKB-569 (75-500 nM) in both A431 and NHEK cells. The effects were specific because EKB-569 did not inhibit the nuclear factor-kappaB pathway. It is proposed that skin toxicity associated with EKB-569 is due to inhibition of EGF-R signaling. Downstream signal transduction markers, particularly the activation status of STAT3, may be useful surrogate markers to guide clinical development of EGF-R inhibitors.
[Immobilization of DNA on microporous membranes using UV-irradiation]. (1992)

Various techniques of DNA immobilization onto nitrocellulose and nylon microporous membranes have been compared. Despite a strong primary adsorption of DNA onto these membranes during blotting procedures, poor retention of the target DNA and low hybridization signals are obtained after hybridization and washings. Covalent cross-linking of DNA upon UV irradiation leads to a quantitative immobilization of target DNA. Quantum yield of DNA photoimmobilization estimated for a single base in DNA is about 10(-4). UV irradiation dose sufficient for immobilization of DNA fragment of a known length can be calculated by the formula Ilc = (22.3 +/- 4.8) c/l, where l is the DNA fragment length (in base pairs), c is the DNA part (%) to be immobilized. The UV irradiation dose about 0.6-0.8 kJ/m2 is optimal for most hybridization experiments. Doses higher than 0.8-1 kJ/m2 may cause a loss in the hybridization efficiency. Under optimal immobilization conditions, hybridization signals increasing five-fold for nitrocellulose membranes and fifty-fold for uncharged nylon membranes as compared with baking these membranes in vacuum.
Star Temporal Classification: Sequence Classification with Partially Labeled Data (2022)

We develop an algorithm which can learn from partially labeled and unsegmented sequential data. Most sequential loss functions, such as Connectionist Temporal Classification (CTC), break down when many labels are missing. We address this problem with Star Temporal Classification (STC) which uses a special \textit{star} token to allow alignments which include all possible tokens whenever a token could be missing. We express STC as the composition of weighted finite-state transducers (WFSTs) and use GTN (a framework for automatic differentiation with WFSTs) to compute gradients. We perform extensive experiments on automatic speech recognition. These experiments show that STC can recover most of the performance of supervised baseline when up to 70\% of the labels are missing. We also perform experiments in handwriting recognition to show that our method easily applies to other sequence classification tasks.
S 3 + E 3 = quality information providers (1998)

Les 3 E sont Sources (etudes des sources disponibles ), Strategie (recherche de ce que veut reellement le client et comment il peut l'obtenir) et Service (comment fournir le service). Les 3 evaluations sont: employer des personnes douees d'esprit critique, determiner la qualite de chaque base cas par cas, et creer une ambiance de service personnalise au client