gebhart/patrepeval huggingface dataset:
Synthesis and Mesoscopic Order of a Sugar-Coated Poly(<i>p</i><i>-</i>phenyleneethynylene) (2002)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTSynthesis and Mesoscopic Order of a Sugar-Coated Poly(p-phenyleneethynylene)Belma Erdogan, James N. Wilson, and Uwe H. F. BunzView Author Information Department of Chemistry and Biochemistry, The University of South Carolina, Columbia, South Carolina 29208 Cite this: Macromolecules 2002, 35, 21, 7863–7864Publication Date (Web):September 4, 2002Publication History Received31 May 2002Revised25 July 2002Published online4 September 2002Published inissue 1 October 2002https://pubs.acs.org/doi/10.1021/ma025564xhttps://doi.org/10.1021/ma025564xrapid-communicationACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views378Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Absorption,Carbohydrates,Conjugated polymers,Polymers,Solvents Get e-Alerts
Clinical and Economic Assessment of Diabetic Foot Ulcer Debridement with Collagenase: Results of a Randomized Controlled Study (2013)

CCO treatment provides equivalent debridement of DFUs similar to SMG while fostering better progress toward healing as measured by decreasing wound area over time and improved response rates at the end of follow-up. In addition, CCO yields a more favorable cost-effectiveness ratio in both the physician office and hospital outpatient department settings of care. ClinicalTrials.gov identifier: NCT01056198.
Production of neutralizing monoclonal antibody against human vascular endothelial growth factor receptor II. (2004)

Our results suggest that the anti-KDR mAb, Ycom1D3, has potential applications in the treatment of cancer and other diseases where pathological angiogenesis is involved.
Some Peculiarities in the P-T Border Curves of Mixtures of Hydrogen and a Petroleum Naphtha. (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Peculiarities in the P-T Border Curves of Mixtures of Hydrogen and a Petroleum Naphtha.W. B. KayCite this: Chem. Rev. 1941, 29, 3, 501–507Publication Date (Print):December 1, 1941Publication History Published online1 May 2002Published inissue 1 December 1941https://pubs.acs.org/doi/10.1021/cr60094a006https://doi.org/10.1021/cr60094a006research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Crush the assholetters between the teeths : Språkgrotesk in Henri Michaux and Gunnar Ekelöf (Part 1) (2009)

Crush the assholetters between the teeths : Sprakgrotesk in Henri Michaux and Gunnar Ekelof (Part 1)
Engineering Pharmaceutical Fine Particles of Budesonide for Dry Powder Inhalation (DPI) (2008)

Budesonide, as one of the inhaled glucocorticosteroids, is widely used in the treatment of asthma by pulmonary delivery. The purpose of this study was to prepare ultra-fine budesonide particles by antisolvent precipitation for dry powder inhalation. Both methanol and acetone were used to make the budesonide solution, and water was chosen as the antisolvent to induce precipitation. Hydroxypropyl cellulose and tyloxapol were added as the stabilizers. The results revealed that crystals of rectangular shape could be obtained from an acetone−water system while elliptic particles were obtained from a methanol−water system. They both had a flaky morphology, no more than 5 µm in length and 300 nm in thickness, and were formed into agglomerates. When the stabilizers were present, uniform spindle or ellipsoidal particles less than 5 µm in diameter could be prepared. All the prepared particles had the same crystalline structure as the commercial budesonide product, as assessed by X-ray diffraction. In vitro evaluation with an Aerolizer inhaler and a multistage liquid impinger (MSLI) showed that the flaky particles had better aerosol performance, because they both achieved a FPFemitted value of over 69%. However, the spindle or ellipsoidal particles had poor dispersibility, because of FPFemitted values of 23 ± 2% and 26 ± 3%, respectively.
Dissociable Connectivity within Human Angular Gyrus and Intraparietal Sulcus: Evidence from Functional and Structural Connectivity (2010)

The inferior parietal lobule (IPL) of the human brain is a heterogeneous region involved in visuospatial attention, memory, and mathematical cognition. Detailed description of connectivity profiles of subdivisions within the IPL is critical for accurate interpretation of functional neuroimaging studies involving this region. We separately examined functional and structural connectivity of the angular gyrus (AG) and the intraparietal sulcus (IPS) using probabilistic cytoarchitectonic maps. Regions-of-interest (ROIs) included anterior and posterior AG subregions (PGa, PGp) and 3 IPS subregions (hIP2, hIP1, and hIP3). Resting-state functional connectivity analyses showed that PGa was more strongly linked to basal ganglia, ventral premotor areas, and ventrolateral prefrontal cortex, while PGp was more strongly connected with ventromedial prefrontal cortex, posterior cingulate, and hippocampus-regions comprising the default mode network. The anterior-most IPS ROIs, hIP2 and hIP1, were linked with ventral premotor and middle frontal gyrus, while the posterior-most IPS ROI, hIP3, showed connectivity with extrastriate visual areas. In addition, hIP1 was connected with the insula. Tractography using diffusion tensor imaging revealed structural connectivity between most of these functionally connected regions. Our findings provide evidence for functional heterogeneity of cytoarchitectonically defined subdivisions within IPL and offer a novel framework for synthesis and interpretation of the task-related activations and deactivations involving the IPL during cognition.
Differences in Therapeutic Efficacy among Cell Wall-Active Antibiotics in a Mouse Model of Gram-Negative Sepsis (1995)

The in vivo efficacy of three cell wall-active antibiotics, imipenem, meropenem, and ceftazidime, was compared in mice rendered hypersusceptible to the pathophysiologic effects of lipopolysaccharide by treatment with D-galactosamine. When CF-1 mice were administered Escherichia coli, D-galactosamine, and saline intraperitoneally, an LD50 was achieved at an inoculum of approximately 2 x 10(4) cfu. Administration of antibiotic at 20 mg/kg resulted in significant but widely variable protective efficacy from E. coli lethality among the three antibiotics. At this dose, an approximately 3-fold increase in LD50 was observed with either meropenem or ceftazidime, whereas administration of imipenem resulted in an approximately 8-fold increase in LD50 (P = .0053). When the dose of antibiotic was decreased to 2 mg/kg, neither meropenem nor ceftazidime could provide measurable protection, whereas imipenem was almost fully protective (P < .002). These differences in protective efficacy were also noted with experimental Pseudomonas aeruginosa but not Staphylococcus aureus infection.
Analysis of burst release of proxyphylline from poly(vinyl alcohol) hydrogels (2003)

The initial high-rate drug release observed at the beginning of many controlled-release processes can be caused by a number of mechanisms, including surface desorption, pore diffusion, or the lack of a diffusion front barrier to regulate the diffusive process. This initial nonsteady-state period is usually referred to as "burst release." A small molecular size drug, proxyphylline, was used as a model solute to study the burst release of a drug from swellable hydrogels based on cross-linked poly(vinyl alcohol) (PVA). The influences of several factors, including drug loading concentration, initial cross-linking ratio of the polymer, initial swollen state of the hydrogel samples, pore diffusion of the drug versus swelling of the hydrogel at the beginning of the release, and osmotic pressure, were investigated to understand the burst behavior. Results show that high drug loading and low cross-linking ratio of the polymer led to more pronounced bursts. Compared to release experiments starting with relaxed samples, samples in dry states had magnified burst effects, but prolonged the release process. Pore diffusion of the drug at the initial stage and the osmotic pressure were shown not to be effective factors leading to burst release within the range of the experimental conditions of this study. Keywords: Controlled ReleaseBurst ReleaseHydrogelPoly(vinyl Alcohol)Proxyphylline
Deriving code coverage information from profiling data recorded for a trace-based just-in-time compiler (2013)

Code coverage information is typically recorded by adding instrumentation to an application before or during execution. However, this has the disadvantage that the instrumentation decreases the performance.
Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death via the Inhibition of iNOS/p38 MAPK and Nitrotyrosine (2014)

Hericium erinaceus, an edible mushroom, has been demonstrated to potentiate the effects of numerous biological activities. The aim of this study was to investigate whether H. erinaceus mycelium could act as an anti-inflammatory agent to bring about neuroprotection using a model of global ischemic stroke and the mechanisms involved. Rats were treated with H. erinaceus mycelium and its isolated diterpenoid derivative, erinacine A, after ischemia reperfusion brain injuries caused by the occlusion of the two common carotid arteries. The production of inflammatory cytokines in serum and the infracted volume of the brain were measured. The proteins from the stroke animal model (SAM) were evaluated to determine the effect of H. erinaceus mycelium. H. erinaceus mycelium reduced the total infarcted volumes by 22% and 44% at a concentration of 50 and 300 mg/kg, respectively, compared to the SAM group. The levels of acute inflammatory cytokines, including interleukin-1β, interleukin-6 and tumor necrosis factor á, were all reduced by erinacine A. Levels of nitrotyrosine-containing proteins, phosphorylation of p38 MAPK and CCAAT enhancer-binding protein (C/EBP) and homologous protein (CHOP) expression were attenuated by erinacine A. Moreover, the modulation of ischemia injury factors present in the SAM model by erinacine A seemed to result in the suppression of reactive nitrogen species and the downregulation of inducible NO synthase (iNOS), p38 MAPK and CHOP. These findings confirm the nerve-growth properties of Hericium erinaceus mycelium, which include the prevention of ischemic injury to neurons; this protective effect seems to be involved in the in vivo activity of iNOS, p38 MAPK and CHOP.
Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen (2014)

Kidney fibrosis is the final common pathway of all progressive chronic kidney diseases, of which diabetic nephropathy is the leading cause. Endothelial-to-mesenchymal transition (EndMT) has emerged as one of the most important origins of matrix-producing fibroblasts. Dipeptidyl peptidase-4 (DPP-4) inhibitors have been introduced into the market as antidiabetes drugs. Here, we found that the DPP-4 inhibitor linagliptin ameliorated kidney fibrosis in diabetic mice without altering the blood glucose levels associated with the inhibition of EndMT and the restoration of microRNA 29s. Streptozotocin-induced diabetic CD-1 mice exhibited kidney fibrosis and strong immunoreactivity for DPP-4 by 24 weeks after the onset of diabetes. At 20 weeks after the onset of diabetes, mice were treated with linagliptin for 4 weeks. Linagliptin-treated diabetic mice exhibited a suppression of DPP-4 activity/protein expression and an amelioration of kidney fibrosis associated with the inhibition of EndMT. The therapeutic effects of linagliptin on diabetic kidneys were associated with the suppression of profibrotic programs, as assessed by mRNA microarray analysis. We found that the induction of DPP-4 observed in diabetic kidneys may be associated with suppressed levels of microRNA 29s in diabetic mice; linagliptin restored microRNA 29s and suppressed DPP-4 protein levels. Using cultured endothelial cells, we found that linagliptin inhibited TGF-β2-induced EndMT, and such anti-EndMT effects of linagliptin were mediated through microRNA 29 induction. These results indicate the possible novel pleiotropic action of linagliptin to restore normal kidney function in diabetic patients with renal impairment.
PREDICTING MEAT TENDERNESS FROM MUSCLE TENSILE PROPERTIES (1972)

Abstract Two major types of objective measurements were performed on raw porcine psoas muscle (I ‐ shearing and breaking strength tests; II ‐ sarcomere length, elasticity, stress relaxation and break elongation) and compared with taste panel evaluation (tenderness, elasticity, and chew count) of cooked meat. A standard sample of texturized vegetable protein used as a reference by the panel proved useful in reducing variations between the chew count test and the objective evaluation; it was not of significant value with the other sensory evaluations. No significant correlations were found between the two groups of objective measurements. Breaking strengths of small longitudinal strips of tissue, following a brief cyclic or extension stretching on the Instron, were the best predictors of sensory tenderness accounting for 59–90% of variation. Other measurements also gave significant correlations. The major source of variation in breaking strength values was the variation between animals, but the post‐mortem treatment (restraining versus not restraining during rigor) and the interaction between animals and the post‐mortem treatment also were significant in some cases. Breaking strengths of uncooked samples from the same muscle showed a coefficient of variation of up to 54%. It is concluded that there are two major structural contributions of raw muscle to cooked meat tenderness, a connective tissue factor and a contraction factor; different objective methods are best suited for their evaluation.
Heat of Adsorption for Hydrogen in Microporous High‐Surface‐Area Materials (2008)

Pore size matters: The heat of adsorption for hydrogen is determined over a wide range of surface coverages for activated carbon and several metal–organic frameworks. Heat determination is based on hydrogen adsorption measurements performed at temperatures between 77 and 296 K (see figure, BTC=benzene-1,3,5-tricarboxylate). The materials with smaller cavities show a higher heat of adsorption for hydrogen.
[Serum serotonin concentration and urine 5-hydroxyindole acetic acid excretion in patients with irritable bowel syndrome]. (2007)

(1) Serotonin concentration is increased in C-IBS and D-IBS patients. (2) Urine 5-hydroxyindole acetic acid excretion is decreased in IBS-subjects. (3) Disturbed metabolism of serotonin probably may play role in pathogenesis of functional bowel diseases.
Compile-time partitioning and scheduling of parallel programs (1986)

Partitioning and scheduling techniques are necessary to implement parallel languages on multiprocessors. Multiprocessor performance is maximized when parallelism between tasks is optimally traded off with communication and synchronization overhead. We present compile-time partitioning and scheduling techniques to achieve this trade-off.
Stencil routed A-Buffer (2007)

We have developed a stencil routing algorithm for implementing a GPU accelerated A-Buffer, by using a multisample texture to store a vector of fragments per pixel. First, all the fragments are captured per pixel in rasterization order. Second, a fullscreen shader pass sorts the fragments using a bitonic sort. At this point, the sorted fragments can be blended arbitrarily to implement various types of algorithms such as order independent transparency or layered depth image generation. Since we handle only 8 fragments per pass, we developed a method for detecting overflow, so we can do additional passes to capture more fragments.
Glucokinase Is a Critical Regulator of Ventromedial Hypothalamic Neuronal Glucosensing (2006)

To test the hypothesis that glucokinase is a critical regulator of neuronal glucosensing, glucokinase activity was increased, using a glucokinase activator drug, or decreased, using RNA interference combined with calcium imaging in freshly dissociated ventromedial hypothalamic nucleus (VMN) neurons or primary ventromedial hypothalamus (VMH; VMN plus arcuate nucleus) cultures. To assess the validity of our approach, we first showed that glucose-induced (0.5-2.5 mmol/l) changes in intracellular Ca(2+) concentration ([Ca(2+)](i)) oscillations, using fura-2 and changes in membrane potential (using a membrane potential-sensitive dye), were highly correlated in both glucose-excited and -inhibited neurons. Also, glucose-excited neurons increased (half-maximal effective concentration [EC(50)] = 0.54 mmol/l) and glucose-inhibited neurons decreased (half-maximal inhibitory concentration [IC(50)] = 1.12 mmol/l) [Ca(2+)](i) oscillations to incremental changes in glucose from 0.3 to 5 mmol/l. In untreated primary VMH neuronal cultures, the expression of glucokinase mRNA and the number of demonstrable glucosensing neurons fell spontaneously by half over 12-96 h without loss of viable neurons. Transfection of neurons with small interfering glucokinase RNA did not affect survival but did reduce glucokinase mRNA by 90% in association with loss of all demonstrable glucose-excited neurons and a 99% reduction in glucose-inhibited neurons. A pharmacological glucokinase activator produced a dose-related increase in [Ca(2+)](i) oscillations in glucose-excited neurons (EC(50) = 0.98 mmol/l) and a decrease in glucose-inhibited neurons (IC(50) = 0.025 micromol/l) held at 0.5 mmol/l glucose. Together, these data support a critical role for glucokinase in neuronal glucosensing.
Flourescence Spectroscopy of Humic Substances (1988)

Abstract Fluorescence spectroscopy has been underutilized as a method to investigate the nature of humic substances. This study was conducted to obtain fluorescence excitation and emission spectra systematically for a variety of humic and fulvic acids of diverse origin. Solutions containing 50 g m −3 humic or fulvic acid at pH values between 4 and 10 were investigated with excitation, emission, and synchronous‐scan excitation modes of fluorescence spectroscopy. The excitation spectra were markedly different for humic vs. fulvic acid and could be used to distinguish unambiguously between the two kinds of humic substance in aqueous solution. The fulvic acid excitation spectra also differed as a function of provenance. The fluorescence emission spectra, although broad, showed maximum‐intensity wavelengths that were lower for humic than for fulvic acids, indicating a greater degree of condensed, aromatic character in humic acids. Synchronous‐scan excitation spectra of the humic substances showed complex lineshapes that depended sensitively on the type of humic substance as well as on the pH value. These spectra, which are unique for fluorescence processes, may have important potential in resolving condensed aromatic structures in humic and fulvic acids.
Phase Change Materials and Their Applications (2018)

Along with the heat transfer mechanism for the development of a latent heat storage unit (LHSU), the choice of the phase change material (PCM) plays an important role. The enviable thermo-physical, kinetic, and chemical properties of PCM with the economy is an essential criterion for efficient thermo-economical LHSU. The most important criteria that have limited widespread use of LHSU are the useful life of phase change materials. For long term performance of LHSU, the PCM used in the system should be thermally stable and reliable. It does not deteriorate its own properties, especially latent heat and melting point after a repeated number of thermal cycles. Thus an exhaustive literature survey is carried out for different types of PCMs used. The primary objective of this chapter is to carry out a critical review of thermal stability of different group of PCM especially for low temperature applications. Further, an extensive list of different PCMs which are undergone thermal cyclic tests by different researchers is prepared. This information is towards the selection of reliable PCM for latent heat storage unit.
Inverted bi-prism phononic crystals for one-sided elastic wave transmission applications (2012)

This work presents the realization of one-sided wave transmission by using a specially engineered phononic crystal structure. It is an inverted bi-prism phononic crystal engineered for a horizontally incident elastic wave at a specific frequency. The incident wave along one direction is shown to be totally reflected by the bi-prism while the incident wave along the opposite direction transmitted through it with refraction, also evident from experiments. An application of the proposed bi-prism may be found in thin elastic strips.
DC/DC Converters Design and Control for Hybrid Power System (2010)

This paper presents ultracapacitor and battery pack modeling with a DC/DC converter in a hybrid power system. Ultracapacitor is dimensioned for peak power requirement and battery pack provides the power in steady state. A Topology structure was analyzed that the ultracapacitor system is connected with battery pack parallel after a bidirectional DC/DC converter. A detailed theoretical analysis on the control strategy of DC/DC converter has been conducted. For reasons of cost and existing components, the experimental test benches are designed in reduced scale. Simulation results obtained from classical PI control strategy are presented shows the control strategy of the DC/DC Converter can meet the requirements of hybrid power system.