gebhart/patrepeval huggingface dataset:
The Addition of Silicon Hydrides to Olefinic Double Bonds. Part III. The Addition to Non-terminal Olefins in the Presence of Chloroplatinic Acid (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Addition of Silicon Hydrides to Olefinic Double Bonds. Part III. The Addition to Non-terminal Olefins in the Presence of Chloroplatinic AcidJohn C. Saam and John L. SpeierCite this: J. Am. Chem. Soc. 1958, 80, 15, 4104–4106Publication Date (Print):August 1, 1958Publication History Published online1 May 2002Published inissue 1 August 1958https://doi.org/10.1021/ja01548a073RIGHTS & PERMISSIONSArticle Views564Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (393 KB) Get e-Alerts Get e-Alerts
SHAPE-BASED IMAGE RETRIEVAL APPLIED TO TRADEMARK IMAGES (2002)

We propose a new shape-based, query-by-example, image database retrieval method that is able to match a query image to one of the images in the database, based on a whole or partial match. The proposed method has two key components: the architecture of the retrieval and the features used. Both play a role in the overall retrieval efficacy. The proposed architecture is based on the analysis of connected components and holes in the query and database images. The features we propose to use are geometric in nature, and are invariant to translation, rotation and scale. Each of the suggested three features is not new per se, but combining them to produce a compact and efficient feature vector is. We use hand-sketched, rotated and scaled query images to test the proposed method using a database of 500 logo images. We compare the performance of the suggested features with the performance of the moment invariants (a set of commonly-used shape features). The suggested features match the moment invariants in rotated and scaled queries and consistently surpass them in hand-sketched queries. Moreover, results clearly show that the proposed architecture significantly increases the performance of the two feature sets.
Which is the preferred vascular access in diabetic patients? A view from Europe (2002)

No abstract available.
Development of the strong migration mobile agent system AgentSphere for autonomic distributed processing (2009)

Authors have developed a strong migration mobile agent system using Java. In order to make strong migration possible on usual JVM, we have already proposed an automatic code transformation method for such agents. In this paper, in order to apply this strong migration mobile agent system to autonomic distributed processing, the system, called AgentSphere, which offers the space where agents can be active is proposed. Agents can perform their processing by entering into AgentSphere on any machine. AgentSphere consists of the core systems and the subsystems which support an agent's activities. As some of the core systems, a class loader which updates class files dynamically with agents' migration and the communication facility among AgentSpheres are designed and implemented. Moreover, as one of the subsystems, a virtual file system for autonomic distributed processing is implemented using out mobile agents.
Theory and design of SEC-DED-AUED codes (1998)

To construct a single error correcting/double error detecting/all unidirectional error detecting (SEC-DED-AUED) codes a common method is to choose a SEC-DED code and then append a stream of extra bits such that the new code can detect all the unidirectional errors. An efficient method for constructing a class of SEC-DED-AUED codes is presented. The encoding/decoding algorithms proposed with this method can be implemented with simple and fast hardware. In a ROM-based implementation it results in significant saving of word length.
Advanced Carcinoma of the Pancreas (1998)

Because of the poor response of pancreatic cancer to conventional therapy, the authors performed a phase II pilot study to evaluate whether beta-interferon and retinoids, added to active chemotherapeutic agents, could increase response rate and survival in a group of patients who had metastatic disease. Twenty-three chemotherapy-naive patients were treated as follows: epirubicin, 60 mg/m2, and mitomycin C, 10 mg/m2, intravenously on day 1; folinic acid, 200 mg/m2, and 5-fluorouracil (5-FU), 370 mg/m2, intravenously for 5 consecutive days. beta-Interferon, 1 x 10(6) IU/m2, subcutaneously three times a week, and retinol palmitate, 50,000 IU orally twice a day, were given between chemotherapy cycles. Patients having responses and disease stabilization were maintained with the same dose of beta-interferon and retinol palmitate. Treatment was given every 4 weeks for four courses or until onset of progression. A median of three courses of chemotherapy was delivered to each patient. All patients were evaluable. Eight patients responded (35%) and 8 (35%) had stable disease. Median time to progression and survival for all patients were, respectively, 6.1 months and 11 months. Toxicity was severe: 60% of patients had hematologic toxicity, 40% had gastrointestinal toxicity, 13% had cardiac toxicity, and 1 patient had a hemolitic-uremic syndrome. The combination of chemotherapy, beta-interferon, and retinoids shows activity in metastatic pancreatic carcinoma. Toxicity was high but patients who had responses and disease stabilization had prolonged symptom palliation.
CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use (2007)

Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.
Optical fiber long-period gratings with Langmuir–Blodgett thin-film overlays (2002)

An overlay material was deposited by the Langmuir-Blodgett technique onto a single-mode optical fiber containing a long-period grating. The long-period grating exhibits characteristic attenuation bands in its transmission spectrum whose central wavelengths were observed to depend on the optical thickness of the overlay material, even for materials that have a refractive index higher than that of silica.
Metal-covered photonic bandgap multilayer for infrared hollow waveguides (2002)

Infrared hollow waveguides utilizing a dielectric multilayer are examined by use of a photonic bandgap theory. It is shown that, in the waveguide consisting of quarter-wave film stack, the act of covering the dielectric films with a metal layer is effective in the reduction of the number of film layers. To verify the effect of this design, we fabricated a prototype waveguide with three dielectric layers of SiO2/Ta2O5/SiO2 and a silver layer by using a liquid-phase coating technique. From the loss spectrum of the fabricated waveguide, it is confirmed that, as designed, the waveguide shows wideband low-loss property at the wavelength of Nd:YAG laser light 1.06 microm.
Modulation of Pulmonary Microbiota by Antibiotic or Probiotic Aerosol Therapy: A Strategy to Promote Immunosurveillance against Lung Metastases (2018)

Pulmonary immunological tolerance to inhaled particulates might create a permissive milieu for lung metastasis. Lung microbiota contribute to pulmonary tolerance; here, we explored whether its manipulation via antibiotic or probiotic aerosolization favors immune response against melanoma metastasis. In lungs of vancomycin/neomycin-aerosolized mice, a decrease in bacterial load was associated with reduced regulatory T cells and enhanced T cell and NK cell activation that paralleled a significant reduction of melanoma B16 lung metastases. Reduction of metastases also occurred in lungs transplanted with bacterial isolates from antibiotic-treated lungs. Aerosolized Lactobacillus rhamnosus strongly promoted immunity against B16 lung metastases as well. Furthermore, probiotics or antibiotics improved chemotherapy activity against advanced B16 metastases. Thus, we identify a role for lung microbiota in metastasis and show that its targeting via aerosolization is a therapy that can prevent metastases and enhance responses to chemotherapy.
ChemInform Abstract: STUDIES ON ACRIDINES. II. SELECTIVE REDUCTION OF NITRO‐SUBSTITUTED DERIVATIVES OF 2‐AMINOACRIDONE BY DIBORANE (1978)

Abstract Untersuchung auf dem Acridingebiet.
Trend of declining stroke mortality in China: reasons and analysis (2017)

The age-adjusted stroke mortality rate in China has shown a downward trend among both urban and rural population in the past 30 years. The major influencing factors that helped in reducing stroke mortality in China included improved healthcare coverage, healthcare environment, the updated treatment options and modern medical technology.
Redefining the Clinical States of Prostate Cancer in the Modern Era (2021)

Cutting-edge treatments that are noninvasive so he can enjoy a life-changing trip around the world ® knowledge that matters ™
Sweeping lymph node micrometastases off their feet: an engineered model to evaluate natural killer cell mediated therapeutic intervention of circulating tumor cells that disseminate to the lymph nodes (2013)

Approximately 90% of cancer related deaths are due to metastasis. Cells from the primary tumor can metastasize through either the vascular or lymphatic circulation. Cancer cells in circulation are called circulating tumor cells (CTCs) and it has been shown that bone marrow is a niche for homing of blood borne CTCs from several epithelial tumors. Cancer cells found in bone marrow are termed disseminated tumor cells (DTCs). Likewise, CTCs in the lymphatic circulation are more often seeded in the sentinel lymph nodes (SLN) that drain the tumor. Micrometastases (<2 mm) occur after the arrest and implantation of DTCs in lymph nodes over time. This paper presents a cell culture platform termed microbubbles formed in polydimethylsiloxane (PDMS) from a microfabricated silicon wafer for mimicking lymph node micrometastases. We cultured lymph node seeking cancer cells in microbubbles to evaluate the efficacy of natural killer (NK) mediated therapy for targeting lymph node micrometastasis. The microbubble platform consists of an array of microcavities that provides a unique microenvironment for mimicking the deep cortical unit of the lymph nodes. We show that cancer cells cultured in microbubbles with therapeutic NK cells undergo apoptosis after 24 h in culture. Since lymph node metastases are prevalent across several types of cancer, this platform may be useful for developing improved cancer therapies for targeting lymph node micrometastases.
Amelioratory Effect of Dietary Ingestion with Red Bell Pepper on Learning Impairment in Senescence-Accelerated Mice (SAMP8). (1999)

The effect of dietary red bell pepper (Capsicum annuum L.) on learning performance was studied in the senescence-accelerated mouse (SAM). An experimental diet, which contained 20% (w/w) lyophilized powder of red bell pepper, was fed to SAMP8 mice. The mice that received the experimental diet showed much better acquisition in passive avoidance tasks as compared with a control group given a common diet. This indicated that the dietary ingestion of red bell pepper ameliorated the learning impairment in SAMP8.
Development of a DMD-based fluorescence microscope (2015)

We present a versatile fluorescence microscope, built by complementing a conventional fluorescence microscope with a digital micro-mirror device (DMD) in the illumination path. Arbitrary patterns can be created on the DMD and projected onto the sample. This patterned illumination can be used to improve lateral and axial resolution over the resolution of a wide-field microscope, as well as to reduce the illumination dose. Different illumination patterns require different reconstruction strategies and result in an image quality similar to confocal or structured illumination microscopy. We focus on the optical design and characterization of a DMD-based microscope. Estimation of the optical quality of the microscope has been carried out by measuring the modulation transfer function from edge profiles. We have obtained optically sectioned images by applying multi-spot illumination patterns followed by digital pinholing. The sectioning capabilities of our DMD-based microscope were estimated from the dependence of the signal-to-background and signalto-noise ratios on the pitch of the projected multi-spot patterns and the size of the digital pinhole. In addition, we provide an outlook on the use of pseudo-random illumination patterns for achieving both sectioning and resolution enhancement.
Inhibitory effects of a cholecystokinin antagonist, loxiglumide (CR‐1505), on the growth of freshly separated and xenografted human pancreatic cancer (1993)

The effects of cholecystokinin (CCK) and a CCK antagonist, loxiglumide (CR-1505), on four freshly separated and six xenografted human pancreatic cancers, were investigated. The level of DNA synthesis in only one of five tested pancreatic cancers was enhanced by CCK at concentrations of 0.01-10 nM, while in the other four cancers DNA synthesis was not affected. The levels of DNA, RNA, and protein synthesis (by 3H-thymidine, 3H-uridine, and 3H-leucine incorporation tests, respectively) in all the tested cancers were dose-dependently inhibited by loxiglumide at concentrations of 20-2000 microM, and the IC50 of loxiglumide for DNA synthesis in pancreatic cancers was 156 +/- 80 microM (means +/- SD). The in vivo effect of loxiglumide was assessed using a xenografted line (PC-HN) transplanted in nude mice. The in vivo 50% lethal dose of loxiglumide for nude mice was about 500 mg/kg. Death was caused by respiratory failure due to severe congestion of the lung after the administration of a large dose of loxiglumide. The growth of a PC-HN transplanted in the nude mice was significantly inhibited by subcutaneous loxiglumide at 250 mg/kg, twice a day for 28 days, which did not cause death. It is suggested that loxiglumide inhibits the in vivo and in vitro growth of human pancreatic cancer, perhaps independently of its action as a CCK antagonist, and this study also suggests that loxiglumide may be a new type of therapeutic agent to be used for the treatment of human pancreatic cancer.
The effect of cavity-filling mutations on the thermostability of <i>Bacillus stearothermophilus</i> neutral protease (1992)

Cavities in the hydrophobic core of the neutral protease of Bacillus stearothermophilus were analyzed using a three-dimensional model that was inferred from the crystal structure of thermolysin, the highly homologous neutral protease of B. thermoproteolyticus (85% sequence identity). Site-directed mutagenesis was used to fill some of these cavities, thereby improving hydrophobic packing in the protein interior. The mutations had small effects on the thermostability, even after drastic changes, such as Leu284----Trp and Met168----Trp. The effects on T50, the temperature at which 50% of the enzyme is irreversibly inactivated in 30 min, ranged from 0.0 to +0.4 degrees C. These results can be explained by assuming that the mutations have positive and negative structural effects of approximately the same magnitude. Alternatively, it could be envisaged that the local unfolding steps, which render the enzyme susceptible towards autolysis and which are rate limiting in the process of thermal inactivation, are only slightly affected by alterations in the hydrophobic core.
THE HELLENISATION OF JUDAEO-CHRISTIAN FAITH OR THE CHRISTIANISATION OF HELLENIC THOUGHT?' (2005)

Abstract <title> Abstract </title>In this article I explore the relationship between faith and reason among the early Christianities. The approach here favours the perspective of social history whereby the establishment of claims to a universal and absolute monotheism in Western society is viewed as an outcome of power relations - or an increasingly close alliance among certain of the early Christianities and between these and the state. In this sense, my thesis is that rather than understanding a Judaeo-Christian faith that became Hellenised, we might better speak of a tradition of Hellenic thought that increasingly became theologised under the dominant sway of Christian power. I explicate this thesis from the point of views or theories proposed by Max Weber and supported by Michel Foucault. As such, what follows is an overview of the conventional view of Christianity, an examination of Weber's view, which is followed by my critique of it, and some concluding remarks.
Herpesvirus Vectors for Therapy of Brain Tumors (2010)

Genetically modified, conditionally-replicating Herpes Simplex Virus Type 1 (HSV-1) vectors for the treatment of malignant glioma have provided encouraging results in the handful of Phase I and Phase II clinical trials conducted to date. In recent years, a number of new strategies have been developed to improve anti-tumor activity of these attenuated vectors, through either introduction of foreign gene inserts to enhance tumor killing through a variety of mechanisms, or through combination with existing treatment regimens, including radiation and/or chemotherapeutics. Another promising new approach has been the engineering of novel oncolytic HSV vectors that retain wildtype replication, but are targeted to tumor cells through a variety of mechanisms. This review summarizes the latest advances in herpesvirus-mediated oncolytic therapies from both preclinical results and clinical trials with oncolytic HSV vectors in patients, and their implication for design of future trials.
Thermally reversible polymer linkages. 3. Covalently crosslinked poly(azlactone) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermally reversible polymer linkages. 3. Covalently crosslinked poly(azlactone)K. B. Wagener and L. P. EngleCite this: Macromolecules 1991, 24, 26, 6809–6815Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ma00026a001https://doi.org/10.1021/ma00026a001research-articleACS PublicationsRequest reuse permissionsArticle Views496Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults (2009)

Previous research examining gene-environment interaction (GxE) with regard to vulnerability to depression and anxiety has yielded conflicting results. The present study was designed to further investigate GxE between 5-HTTLPR and exposure to environmental adversity, using different phenotypic and genotypic characterizations as well as different types of adversity within a prospective study design. Data were available from an ongoing epidemiological cohort study following the outcome of early risk factors from birth to adulthood. At age 19 yr, 309 participants (142 males, 167 females) were characterized on measures of depression and anxiety through interview and questionnaire (DSM-IV diagnosis, Beck Depression Inventory, Harm Avoidance). Environmental adversity was assessed at birth (family adversity), and at age 19 yr (stressful life events). Bi- and tri-allelic 5-HTTLPR genotypes were obtained from genomic DNA. Results indicated that depression and anxiety in 19-yr-olds were strongly associated with both family adversity and stressful life events. Individuals with the LL genotype of 5-HTTLPR who were exposed to high family adversity displayed significantly higher rates of depressive or anxiety disorders and had more depressive symptoms than those without either condition. This GxE replicates recent findings from an epidemiological cohort study of adolescents but is in contrast to many previous reports suggesting an interaction with the S allele. No evidence for GxE was obtained with regard to current stressful life events and trait anxiety. One possible source for the conflicting findings might be attributed to heterogeneity in depression phenotypes and environmental adversity.
A study of the thermal degradation of poly(mono‐n‐alkyl itaconates) (1995)

Abstract The thermal degradation of the first six members of poly(mono‐n‐alkyl itaconates) by thermogravimetry (TG), differential scanning calorimetry (DSC), Fourier Transform infrared (FTIR) and FTIR evolved gas analysis (FTIR‐EGA) was studied. The degradation mechanism involves cyclic anhydride formation followed by crosslinking due to the linear anhydride formation. In both processes water and/or alcohol evolution was detected. Also, decarboxylation processes take place on all polymers at high temperatures ( > 180°C). A mechanism of the degradation process is proposed.
Graphene-based mid-infrared room-temperature pyroelectric bolometers with ultrahigh temperature coefficient of resistance (2017)

There is a growing number of applications demanding highly sensitive photodetectors in the mid-infrared. Thermal photodetectors, such as bolometers, have emerged as the technology of choice, because they do not need cooling. The performance of a bolometer is linked to its temperature coefficient of resistance (TCR, ∼2-4% K<sup>-1</sup> for state-of-the-art materials). Graphene is ideally suited for optoelectronic applications, with a variety of reported photodetectors ranging from visible to THz frequencies. For the mid-infrared, graphene-based detectors with TCRs ∼4-11% K<sup>-1</sup> have been demonstrated. Here we present an uncooled, mid-infrared photodetector, where the pyroelectric response of a LiNbO<sub>3</sub> crystal is transduced with high gain (up to 200) into resistivity modulation for graphene. This is achieved by fabricating a floating metallic structure that concentrates the pyroelectric charge on the top-gate capacitor of the graphene channel, leading to TCRs up to 900% K<sup>-1</sup>, and the ability to resolve temperature variations down to 15 μK.