gebhart/patrepeval huggingface dataset:
A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs (2009)

Natural products represent a rich reservoir of potential small chemical molecules exhibiting antiproliferation and anticancer properties. An example is berberine, a protoberberine alkaloid widely distributed in medical plants used in traditional Chinese prescriptions. Recent advances have shown that berberine exerts anticancer activities both in vitro and in vivo through different mechanisms. Berberine shows inhibitory effects on the proliferation and reproduction of certain tumorigenic microorganisms and viruses, such as Heliobacter pylori and hepatitis B virus. Transcriptional regulation of some oncogene and carcinogenesis-related gene expression and interaction with both DNA and RNA are also well documented. Besides, berberine is a broad spectrum enzyme inhibitor, which affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. These actions, together with the regulation of reactive oxygen species production, mitochondrial transmembrane potential, and nuclear factor-kappaB activation might underlie its antiproliferative and proapoptotic effects. More importantly, the suppression of tumor growth and metastasis, the beneficial application in combined medication, and the improvement of multidrug resistance both in vivo and in vitro clearly show its potential as an alternative medicine for tumor chemotherapy.
Spatiotemporal Characteristics of Junctional and Nonjunctional Focal Ca <sup>2+</sup> Release in Rat Atrial Myocytes (2003)

Atrial myocytes have two functionally separate Ca2+ release sites: those in peripheral sarcoplasmic reticulum (SR) adjacent to the Ca2+ channels of surface membrane and those in central SR not associated with Ca2+ channels. Recently, we have reported on the gating of these two different Ca2+ release sites by Ca2+ current. In the present study, we report on the spatiotemporal properties of focal Ca2+ releases (sparks) occurring spontaneously in central and peripheral sites of voltage-clamped rat atrial myocytes, using rapid 2-dimensional (2-D) confocal Ca2+ imaging. Peripheral and central sparks were similar in size and release time (approximately 300 000 Ca2+ ions for congruent with 12 ms), but significantly larger and longer than ventricular sparks. Both sites were resistant to Cd2+ and inhibited by ryanodine. Peripheral sparks were brighter and flattened against surface membrane, had approximately 5-fold higher frequency, approximately 2 times faster diffusion coefficient, and dissipated abruptly. Central sparks, in contrast, occurred less frequently, were elongated along the cellular longitudinal axis, and dissipated slowly. Compound sparks (composed of 2 to 5 unitary focal releases) aligned longitudinally and occurred more frequently at the center. The diversity of peripheral and central sparks with respect to shape, frequency, and speed of spatial development and decay is consistent with regional ultrastructural heterogeneity of SR. The retarded dissipation of central atrial sparks, and high prevalence of compound sparks in cell center may be critical in facilitating the propagation of Ca2+ waves in atrial myocytes lacking t-tubular system and provide the atrial myocytes with functional Ca2+ signaling diversity. The full text of this article is available at http://www.circresaha.org.
Stem Cell Models of Cardiac Development and Disease (2010)

The past few years have witnessed remarkable advances in stem cell biology and human genetics, and we have arrived at an era in which patient-specific cell and tissue models are now practical. The recent identification of cardiovascular progenitor cells, as well as the identification of genetic variants underlying congenital heart disorders and adult disease, opens the door to the development of human models of human cardiovascular disease. We review the current understanding of the contribution of progenitor cells to cardiogenesis and outline how pluripotent stem cells can be applied to the modeling of cardiovascular disorders of genetic origin. A key challenge will be to implement these models in an efficient manner to develop a molecular understanding of how genes lead to disease and to screen for genes and drugs that modify the disease process.
Microcolumn liquid chromatography of benzoyl derivatives of steroid metabolites (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicrocolumn liquid chromatography of benzoyl derivatives of steroid metabolitesMilos. Novotny, Mark. Alasandro, and Masaharu. KonishiCite this: Anal. Chem. 1983, 55, 14, 2375–2377Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/ac00264a038https://doi.org/10.1021/ac00264a038research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
pH-Sensitive Solid-State Electrode Based on Electrodeposited Nanoporous Platinum (2005)

The nanoporous platinum oxide (H1-ePtO) as a hydrogen ion-selective sensing material is reported. Bare nanoporous platinum oxides exhibit near-Nernstian behavior (e.g., -55 mV/pH in PBS), ignorable hysteresis, a short response time, and high precision, which are remarkably better than those of flat platinum oxides. The electrode potential of a nanoporous platinum oxide responds exclusively to hydrogen ion, which implies its usefulness as a solid-state pH sensor. In the present study, the performance of nanoporous platinum oxide was investigated and compared with that of IrOx in terms of selectivity and the influences of ionic strength, temperature, complexing ligands, and surfactants. H1-ePtO functions well as a pH-sensing solid-state material, and it is viewed as a promising alternative to IrOx. Interference by redox couples was successfully suppressed by covering the H1-ePtO surface with a protective layer, e.g., an electropolymerized polyphenol thin film. Since the nanoporous platinum oxide with such a protective layer is particularly suitable for miniaturization and micropatterning, our findings suggest its usefulness in applications such as solid-state pH sensors embedded in chip-based microanalysis systems.
Antisense RNA suppression of peroxidase gene expression (1989)

Retinoic acid (RA), a metabolic product of vitamin A, has been shown to affect a variety of immune functions, including monocytes. Monocyte functions and mediator production are also modulated by ethanol exposure. This study demonstrates that therapeutic doses of RA (0.1-10 microM) significantly increase transforming growth factor-beta (TGF beta) production both in THP-1, human myelomonocytic cells, and in human peripheral blood monocytes. We have previously reported TGF beta induction by ethanol in human M theta. Combination of RA stimulation with acute in vitro ethanol treatment, however, resulted in significantly lower M theta TGF beta production than TGF beta levels induced by RA alone (p < 0.003). Down-regulation of M theta TGF beta production by ethanol was tested at the concentration range of 25-150 mM and occurred both at high and low RA concentrations (10-0.1 microM). In contrast to its inhibitory effect on RA-induced M theta TGF beta production, ethanol augmented TGF beta production induced by muramyl dipeptide (20 micrograms/ml), suggesting that ethanol can either up- or down-regulate M theta TGF beta production, depending on the costimulatory factors. RA also induced a moderate increase in M theta tumor necrosis factor-alpha (TNF alpha) production, which was down-regulated by ethanol both at the level of secreted and cell-associated TNF alpha. In addition to regulation of cytokine production, both RA and ethanol decreased expression of CD4 on THP-1 cells. The degree of inhibition of CD4 expression by RA was more significant than by ethanol, but RA-induced decrease in CD4 expression was not significantly affected by the combined stimulation with ethanol.(ABSTRACT TRUNCATED AT 250 WORDS)
Rough Music, Futurism, and Postpunk Industrial Noise Bands (2013)

Rough is the name given in England for the practice of noisy, masked demonstrations which were usually held at the residence of some wrongdoer in the community. From the very rich historical materials on carnival and the carnivalesque in early modern Europe, including the historical work of scholars such as E. P. Thompson and Natalie Davis, one gathers that these demonstrations involved the banging of sauce pans, frying pans, kettles, the rattling of bones and cleavers, bell-ringing, hooting, blowing bull's horns, and generally playing any other possible utensils gathered from the kitchen and barnyard in the interest of creating a tremendous and, to the object of these serenades which lasted for days, very embarrassing din (Illus. I).1 Participants in these music groups, which lasted well into the nineteenth century, were most often young men bachelors
Continuous Circulation During Drilling Utilizing a Drillstring Integrated Valve—The Continuous Circulation Valve (2006)

Abstract A Continuous Circulation Valve, CCV, was developed for enabling drilling in depleted reservoirs in the Norwegian sector of the North Sea. By utilizing a system to obtain circulation throughout the whole drilling operation, the down hole pressure will remain constant even during drill pipe connections. By balancing this down hole pressure between a maximum pore pressure and a minimum fracture pressure, drilling can be performed properly even through narrow drilling windows. The valve is a two position three way ball valve. It is possible to circulate through the valve from the top drive down the drill string or through a side port and down the drill string. Such a valve must be installed at the top of each drill pipe stand before the continuous circulation operation starts. When a connection is to be performed, a hose must be connected to the side inlet of the valve, the flow from the mud pumps will then be switched from the top inlet to the side inlet and top drive can then be disconnected and a new stand installed. To continue drilling, the operation is reversed. The valve is designed to withstand HPHT pressures including gas filled casings, bull heading and maximum pressure during standard drilling operation. A prototype of the valve has been produced and operation tested on the full scale research drilling rig "Ullrigg" in Stavanger, Norway. The current paper presents in detail the advantages gained by using the CCV in a drilling operation. The paper gives a thorough description of the valve and its performance. The "Ullrigg" test of the prototype is described in detail.
Metabolic bone disease is present at diagnosis in patients with inflammatory bowel disease (2002)

The bone mineral density is reduced at diagnosis, prior to corticosteroid treatment, in both Crohn's disease and ulcerative colitis. Our data suggest that this is attributable to increased resorption rather than decreased bone formation.
Learning n-best correction models from implicit user feedback in a multi-modal local search application (2008)

We describe a novel n-best correction model that can leverage implicit user feedback (in the form of clicks) to improve performance in a multi-modal speech-search application. The proposed model works in two stages. First, the n-best list generated by the speech recognizer is expanded with additional candidates, based on confusability information captured via user click statistics. In the second stage, this expanded list is rescored and pruned to produce a more accurate and compact n-best list. Results indicate that the proposed n-best correction model leads to significant improvements over the existing baseline, as well as other traditional n-best rescoring approaches.
Reflective physical prototyping through integrated design, test, and analysis (2006)

Prototyping is the pivotal activity that structures innovation, collaboration, and creativity in design. Prototypes embody design hypotheses and enable designers to test them. Framin design as a thinking-by-doing activity foregrounds iteration as a central concern. This paper presents d.tools, a toolkit that embodies an iterative-design-centered approach to prototyping information appliances. This work offers contributions in three areas. First, d.tools introduces a statechart-based visual design tool that provides a low threshold for early-stage prototyping, extensible through code for higher-fidelity prototypes. Second, our research introduces three important types of hardware extensibility - at the hardware-to-PC interface, the intra-hardware communication level, and the circuit level. Third, d.tools integrates design, test, and analysis of information appliances. We have evaluated d.tools through three studies: a laboratory study with thirteen participants; rebuilding prototypes of existing and emerging devices; and by observing seven student teams who built prototypes with d.tools.
A low power error detection in the Chien Search Block for Reed-Solomon code (2012)

The Reed-Solomon (RS) codes are widely used in communication systems and data storages to recover data from possible errors that occur during transmission and from disk error respectively. This paper describes a new method for error detection in the Chien Search block of RS decoders. The main feature of this method is to introduce a factorization of the error locator polynomial, which allowed us to reduce the number of components required to implement the algorithm of Chien Search Block of RS decoders on FPGA board and consequently reduces the power consumption with a percentage which can reach 50 % compared to the basic RS decoder. The design for Chien Search Block was created and the hardware description language source code was generated and simulated using Quartus software tools.
Detection of Interleukin 2 in the Urine of Patients with Superficial Bladder Tumors after Treatment with Intravesical BCG (1986)

Adjuvant intravesical BCG therapy is an effective means of treating superficial bladder tumors. The mechanism by which BCG mediates antitumor activity is not known; however, clinical and animal studies suggest that immunological responsiveness to BCG antigens correlates with antitumor activity. In this report the detection of interleukin 2 (IL-2, a lymphokine produced in response to BCG) in urine specimens of patients treated with intravesical BCG is reported. Patients with superficial transitional cell carcinoma of the bladder received intravesical BCG once each week for six weeks. No intradermal injections were administered. Urine specimens were obtained prior to BCG instillation and four, eight and 24 hours afterwards. The specimens were dialysed, concentrated five-fold and assayed for the presence of IL-2 in a biological assay using an IL-2 dependent cultured T-cell line. IL-2 was detected in urine but not serum after intravesical BCG instillation. IL-2 was characterized by absorption against an IL-2-dependent T cell line and neutralization by monoclonal anti-IL-2 antibodies. No IL-2 was detected in specimens obtained prior to BCG instillation or from donors with no detectable bladder pathology. One of 10 urine specimens from patients with urinary tract infections had detectable IL-2 levels. IL-2 production generally peaked during the fourth to sixth intravesical BCG treatment. Production was short-term in that IL-2 levels peaked four to eight hours after BCG instillation and were rarely (six of 54 specimens) observed 24 hours after instillation. Mean IL-2 levels were higher in patients who were rendered tumor free after BCG therapy but statistical significance was not achieved. Ten of 12 patients (83%) who responded to BCG therapy had urine IL-2 levels greater than or equal to 1.6 units/ml. at least once during the six week treatment period while two of six (33%) patients not responding to therapy had similar urine IL-2 levels. These results show that intravesical BCG therapy induces the production of lymphokines including IL-2. The presence of BCG-induced lymphokines may be associated with anti-tumor activity.
The Preparation and Polymerization of p-Vinylbenzyl Ethers (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation and Polymerization of p-Vinylbenzyl EthersEarl C. Chapin, John G. Abramo, and Virginia L. LyonsCite this: J. Org. Chem. 1962, 27, 7, 2595–2597Publication Date (Print):July 1, 1962Publication History Published online1 May 2002Published inissue 1 July 1962https://pubs.acs.org/doi/10.1021/jo01054a070https://doi.org/10.1021/jo01054a070research-articleACS PublicationsRequest reuse permissionsArticle Views285Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mammalian CHORD‐containing protein 1 is a novel heat shock protein 90‐interacting protein (2004)

With two tandem repeated cysteine- and histidine-rich domains (designated as CHORD), CHORD-containing proteins (CHPs) are a novel family of highly conserved proteins that play important roles in plant disease resistance and animal development. Through interacting with suppressor of the G2 allele of Skp1 (SGT1) and Hsp90, plant CHORD-containing protein RAR1 (required for Mla resistance 1) plays a critical role in disease resistance mediated by multiple R genes. Yet, the physiological function of vertebrate CHORD-containing protein-1 (Chp-1) has been poorly investigated. In this study, we provide the first biochemical evidence demonstrating that mammalian Chp-1 is a novel Hsp90-interacting protein. Mammalian Chp-1 contains two CHORD domains (I and II) and one CS domain (a domain shared by CHORD-containing proteins and SGT1). With sequence and structural similarity to Hsp90 co-chaperones p23 and SGT1, Chp-1 binds to the ATPase domain of Hsp90, but the biochemical property of the interaction is unique. The Chp-1-Hsp90 interaction is independent of ATP and ATPase-coupled conformational change of Hsp90, a feature that distinguishes Chp-1 from p23. Furthermore, it appears that multiple domains of Chp-1 are required for stable Chp-1-Hsp90 interaction. Unlike SGT1 whose CS domain is sufficient for Hsp90 binding, the CS domain of Chp-1 is essential but not sufficient for Hsp90 binding. While the CHORD-I domain of Chp-1 is dispensable for Hsp90 binding, the CHORD-II domain and the linker region are essential. Interestingly, the CHORD-I domain of plant RAR1 protein is solely responsible for Hsp90 binding. The unique Chp-1-Hsp90 interaction may be indicative of a distinct biological activity of Chp-1 and functional diversification of CHORD-containing proteins during evolution.
Geant4‐DNA example applications for track structure simulations in liquid water: A report from the Geant4‐DNA Project (2018)

This Special Report presents a description of Geant4-DNA user applications dedicated to the simulation of track structures (TS) in liquid water and associated physical quantities (e.g., range, stopping power, mean free path…). These example applications are included in the Geant4 Monte Carlo toolkit and are available in open access. Each application is described and comparisons to recent international recommendations are shown (e.g., ICRU, MIRD), when available. The influence of physics models available in Geant4-DNA for the simulation of electron interactions in liquid water is discussed. Thanks to these applications, the authors show that the most recent sets of physics models available in Geant4-DNA (the so-called "option4" and "option 6" sets) enable more accurate simulation of stopping powers, dose point kernels, and W-values in liquid water, than the default set of models ("option 2") initially provided in Geant4-DNA. They also serve as reference applications for Geant4-DNA users interested in TS simulations.
Diagnosis of Pulmonary Embolism (1978)

IEEE 802.15.4 was developed to meet the needs for low-rate wireless communication. However, due to its low power, IEEE 802.15.4 is potentially vulnerable to interference by other wireless technologies having much higher power and working in the same industrial, scientific, and medical (ISM) band such as IEEE 802.11 b/g. The paper therefore focuses on the coexistence impact of IEEE 802.11 b/g on the IEEE 802.15.4. In this paper, we present a coexistence model of IEEE 802.15.4 and IEEE 802.11 b/g, which exposes the interactive behavior between these two standards and therefore accurately explains their coexistence performance. The model focuses on two aspects, namely power and timing. These two aspects jointly impose different impacts on the performance of IEEE 802.15.4 networks, depending on coexistence situations. To classify the coexistence situations, we introduce a concept of coexistence range, by extending the concept of sensing and interference ranges across different wireless standards. We characterize the coexistence behavior in each coexistence range and identify for each range the underlying coexistence mechanism and protocol interactions. Analytical models are proposed for the case of saturated traffic and simulation results are presented to validate the model.
Room Temperature Pulsed Operation of Nitride Based Multi-Quantum-Well Laser Diodes with Cleaved Facets on Conventional C-Face Sapphire Substrates (1996)

We demonstrate room temperature pulsed operation of nitride based multi-quantum-well (MQW) laser diodes with cleaved mirror facets grown on a conventional C-face sapphire substrate. Cleavage was performed along the <11*BAR*2*BAR*0> direction of the sapphire substrate, and the resultant facet was analyzed using an atomic force microscope (AFM) and theoretical calculation. A single peak emisson, at a wavelength of 417.5 nm, with a full width at half-maximum of 0.15 nm, was obtained. The threshold current density of the laser was 50 kA/cm 2 and a voltage for the threshold current was 20 V.
Dual band folded monopole/loop antenna for terrestrialcommunication system (2000)

With the introduction of DCS1800 to meet the demands for a wider frequency spectrum for mobile communication systems, novel antenna structures capable of generating dual resonance are in demand. An antenna structure based on the geometry of a bent folded monopole antenna capable of dual resonance frequencies operation is discussed. This antenna is able to cover the GSM/DCS1800 communication system bands.