gebhart/patrepeval huggingface dataset:
In vitro evaluation of the new anticancer agents KT6149, MX-2, SM5887, menogaril, and liblomycin using cisplatin- or adriamycin-resistant human cancer cell lines. (1989)

A new model to predict antitumor activity of new analogues was developed, and the cross-resistance against cisplatin (CDDP) and Adriamycin (ADM) was examined. A preclinical evaluation of various new analogues using this new model was performed. The antitumor activities of KT6149, MX-2 (KRN8602), SM5887, menogaril (TUT-7), and liblomycin (NK313) were evaluated against four non-small cell lung cancer cell lines, PC-7, -9, -13, and -14; two small cell lung cancer cell lines, H69 and N231; four CDDP-resistant cell lines, PC-7/1.0, PC-9/0.5, PC-14/1.5, and H69/0.4; a human myelogenous leukemia cell line, K562; and its ADM-resistant subline, K562/ADM by clonogenic assay. The relative antitumor activities of these new analogues were compared with those of parental agents, mitomycin C, ADM, bleomycin, and several anticancer drugs, CDDP, daunomycin, vindesine, and etoposide. KT6149 was more active than mitomycin C against all lung cancer cell lines and the human myelogenous leukemia cell line. Menogaril showed greater activity than ADM, and MX-2 showed activity similar to ADM. However, the antitumor activity of SM5887 was lower than that of ADM. SM5887 and menogaril showed cross-resistance to K562/ADM. Nevertheless, the antitumor activity against K562/ADM of MX-2 was similar to that of the parental cell lines. The activity of liblomycin was similar to that of bleomycin. Thus, KT6149 appears to be the best analogue for use in a clinical trial against lung cancer. MX-2 was active even against ADM-resistant cancer cells. The values of relative resistance to CDDP or ADM were 4.7, 8.1, 7.5, 20.0, and 13.6 for PC-7/1.0, PC-9/0.5, PC-14/1.5, H69/0.4, and K562/ADM, respectively. CDDP-resistant cell lines showed no cross-resistance with other drugs in this study. K562/ADM showed cross-resistance against daunomycin, etoposide, and vindesine. In contrast, mitomycin C and bleomycin had nearly equal activity against K562 and K562/ADM. However, K562/ADM was 2.4-fold more sensitive to CDDP than its parental cell line, K562 (P less than 0.001). These results suggested that the mechanism of CDDP resistance is different from that of multidrug resistance.
Evaluating Appearance Models for Recognition, Reacquisition, and Tracking (2007)

Traditionally, appearance models for recognition, reacquisition and tracking problems have been evaluated independently using metrics applied to a complete system. It is shown that appearance models for these three problems can be evaluated using a cumulative matching curve on a standardized dataset, and that this one curve can be converted to a synthetic disambiguation rate for single camera tracking or a synthetic reacquisition rate for cross camera tracking. A challenging new dataset for viewpoint invariant pedestrian recognition (VIPeR) is provided as an example. This dataset contains 632 pedestrian image pairs from arbitrary viewpoints. Several baseline methods are tested on this dataset and the results are presented as a benchmark for future appearance models and matching methods. 1.
Determination of Competitive Adsorption and Desorption of Heavy Metals by Isotherm and Sequential Extraction Methods in Different Soil Orders in Erzurum Plain (2010)

The objective of this study was to DTPA (complexion agent) and a sequential extraction procedure, and adsorption-desorption isotherm (competitive) evaluate the mobility and distribution of Fe, Zn, Mn. Cu. Cd, Ni, and Pb using the in surface samples of five soil great groups differing in their physicochemical properties. For determining heavy metal adsorption and desorption capacities of soil samples, six different concentrations (0. 2.5. 5, 10, 15 and 20mg L^(-1)) were used in a laboratory experiment with tree replications. An analytical procedure involving sequential chemical extractions has been used for partitioning of heavy metals into five fractions. Sorption isotherms were characterized using linear, Frendlich and Langmuir equations. The results indicated that the selective sequences of the metal adsorption based on the distribution coefficient was Pb＞Cu＞Ni＞Cd＞Zn＞Mn＞Fe and Pb. Cu. and Ni are the most strongly sorbed metals by these soils, whereas Cd. Zn and Mn are the least sorbed ones. The total adsorbed amount of these metals on the studied soils was well described by Langmuir equation. Calciorthid had the highset Pb. Cu, Ni. Cd. Zn. Mn. and Fe adsorption. and the sequences followed order Fluvaquent＞Argiustoll＞Pellustert＞l-laplustept of the studied soil.
A novel synthesis of sulfonated polybutadiene ionomer by a phase-transfer catalyst (1999)

The tetrabutylammonium bromide catalysed sulfonation of cis-1,4-polybutadiene in the presence of alkaline sodium bisulfite was successfully carried out without crosslinking. The sulfur content was analysed by XPS and the Schöniger method. The sulfonated polybutadiene was characterised by IR, 1H and 13C NMR spectroscopy. The probable reaction mechanism of a radical anion transfer is proposed. Conclusions regarding the ionomer formation are drawn by interpreting the glass transition (Tg) and reduced viscosity (ηred) data.
Universal Flu Vaccines: <i>Primum non nocere</i> (2013)

Envisioning universal influenza vaccines that induce antibodies to conserved viral epitopes is exciting, but first we need to better understand the balance of effects caused by neutralizing and nonneutralizing antibodies (Khurana et al., this issue).
APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells (2017)

A key feature of prostate cancer progression is the induction and activation of survival proteins, including the Inhibitor of Apoptosis (IAP) family member survivin. Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional protein that is essential in activating oncogenic transcription factors. Because APE1/Ref-1 is expressed and elevated in prostate cancer, we sought to characterize APE1/Ref-1 expression and activity in human prostate cancer cell lines and determine the effect of selective reduction-oxidation (redox) function inhibition on prostate cancer cells <i>in vitro</i> and <i>in vivo</i>. Due to the role of oncogenic transcriptional activators NFĸB and STAT3 in survivin protein expression, and APE1/Ref-1 redox activity regulating their transcriptional activity, we assessed selective inhibition of APE1/Ref-1's redox function as a novel method to halt prostate cancer cell growth and survival. Our study demonstrates that survivin and APE1/Ref-1 are significantly higher in human prostate cancer specimens compared to noncancerous controls and that APE1/Ref-1 redox-specific inhibition with small molecule inhibitor, APX3330 and a second-generation inhibitor, APX2009, decreases prostate cancer cell proliferation and induces cell cycle arrest. Inhibition of APE1/Ref-1 redox function significantly reduced NFĸB transcriptional activity, survivin mRNA and survivin protein levels. These data indicate that APE1/Ref-1 is a key regulator of survivin and a potentially viable target in prostate cancer.
Opioid Systems and Magnetic Field Effects in the Land Snail, <i>Cepaea nemoralis</i> (1991)

Accumulating evidence shows that magnetic fields can affect a variety of opioid-mediated behavioral and physiological functions. The idea that endogenous opioids are involved in the mediation of fundamental behavioral responses in invertebrates is also gaining support. Evidence exists for opioid involvement in the mediation of nociceptive and antinociceptive ("analgesic") responses of the land snail, Cepaea nemoralis, and other mollusks, in a manner comparable to that in vertebrates. Exposure to various magnetic stimuli, including weak 60 Hz magnetic fields, has significant inhibitory effects on exogenous opiate-induced analgesia and endogenous opioid-mediated nociceptive responses of Cepaea in a manner analogous to that described for vertebrates. These effects of the magnetic stimuli are evident under both laboratory and natural conditions and include disruptions of the day-night rhythms of opioid-mediated nociception. These similar effects in Cepaea and rodents raise the possibility of a phylogenetic continuity in the effects of magnetic fields on basic opioid-mediated biological responses.
Protein Crystals as Novel Microporous Materials (1998)

Cross-linked protein crystals (CLPCs) constitute a novel type of molecular sieves with high porosity. In order to characterize the fully hydrated CLPC, the method of macromolecular porosimetry was applied. This technique allows one to estimate the apparent pore sizes and pore size distribution in solid and soft hydrated porous sorbents directly from size exclusion chromatography. According to this method, CLPCs offer a wide range of pore size (15−100 Å), porosity (0.5−0.8), and pore surface area (800−2000 m2/g). These CLPC materials can be made chemically and mechanically stable, and are capable of separating molecules by size, chemical structure, and chirality.
Severe Emphysema Treated by Endoscopic Bronchial Volume Reduction with Lung Sealant (AeriSeal) (2013)

Endoscopic lung volume reduction using lung sealant is a very new and innovative treatment option for patients with severe progressive and irreversible lung emphysema. A 55-year-old ex-smoker (60 pack years) referred to our center because of severe lung emphysema with progressive worsening of the obstructive ventilator pattern and clinical condition. We detected collateral channels of this patient by using the Chartis system. Therefore, we decided to treat the advanced emphysema of our patient with endoscopic volume reduction using lung sealant (AeriSeal). The foam of lung sealant AeriSeal is instilled into the peripheral airways and alveoli where it polymerizes and functions as tissue glue on the lung surface in order to seal the target region to cause durable irreversible absorption atelectasis. The follow-up evaluation 12 weeks later showed improved lung function (increased FEV 1/partial oxygen pressure/peripheral oxygen saturation and a reduction of TLC and RV) with improved quality of life. Correlation between changes in primary and secondary outcome measures in the lung function parameters and 6-minute-walking test before and 12 weeks after the application of lung sealant revealed significant reduction of hyperinflation and improvement both in the flow rates and in the physical capability of this patient.
Response in distant lymph nodes of mice to infection in the hind footpad with Mycobacterium marinum (1980)

In an attempt to demonstrate the importance of the popliteal lymph node in limiting the progress of infection with Mycobacterium marinum in the hind footpads of C57BL mice, such infections were studied in mice subjected to popliteal or popliteal and inguinal adenectomies. In the absence of the popliteal node, the footpad infection was only slightly enhanced compared with infections of sham-operated control mice; the inguinal node was found to be greatly enlarged and appeared to have substituted for the absent popliteal node. In the absence of both popliteal and inguinal nodes, the disease process in the footpads was again only slightly enhanced, and the axillary node appeared to have enlarged greatly and to have functionally replaced the missing, more proximate nodes. In additional experiments, mice subjected to adenectomy only on one side and injected in that hind footpad with phytohemagglutinin or India ink demonstrated hypertrophy or deposition of carbon particles in the more distant node only on the side of the injection. Thus, there appear to be rather direct functional connections among popliteal, inguinal, and axillary nodes that do not depend on blood circulation.
Two‐Dimensional Image Processing and Analysis (1997)

image processing; image analysis; overview Processing and analysis of image data require very different methods than those used in flow cytometry.
Convolutive reduced rank Wiener filtering (2002)

If two wide-sense stationary time series are correlated then one can be used to predict the other. The reduced rank Wiener filter is the rank-constrained linear operator which maps the current value of one time series to an estimate of the current value of the other time series in an optimal way. A closed-form solution exists for the reduced rank Wiener filter. This paper studies the problem of determining the reduced rank FIR filter which optimally predicts one time series given the other. This optimal FIR filter is called the convolutive reduced rank Wiener filter, and it is proved that determining it is equivalent to solving a weighted low rank approximation problem. In certain cases a closed-form solution exists, and in general, the iterative optimisation algorithm derived here can be used to converge to a locally optimal convolutive reduced rank Wiener filter.
Magnetically-driven bi-directional optical microscanner (2003)

A magnetically-driven bi-directional optical microscanner has been designed, fabricated and characterized. Magnetic and structural modeling and analysis has been applied to the design of the scanner. The micromachined scanner can be operated bi-directionally under the condition of static operation. Under dynamic operation, the prototype scanner has shown stable bi-directional scanning performance at the operating frequency of 30 Hz, corresponding to 60 Hz in the regular uni-directional scanner. Compared with a conventional scanner, the microscanner has the advantages of low power consumption due to its small size and high scanning efficiency as a result of unique bi-directional actuation.
Establishment and characterization of an immature human megakaryoblastic cell line, MEG-A2. (1995)

We have established a novel human megakaryoblastic cell line, designated as MEG-A2, from a patient with megakaryoblastic crisis of Philadelphia (Ph) chromosome positive chronic myelogenous leukemia. MEG-A2 cells showed positive phenotypes for periodic acid Schiff and alpha-naphthylbutyrate esterase reactions, but were negative for myeloperoxidase and naphthol ASD chloroacetate esterase reactions. Flow cytometric analyses of cell surface markers revealed that MEG-A2 cells had a low level of GP IIb/IIIa expression as well as apparent expressions of CD4, CD7, CD13, CD33 and CD34 antigens, but no expression of GP Ib nor glycophorin A. Stimulation with phorbol 12-myristate 13-acetate (PMA) dramatically increased the expression of megakaryocyte-related markers such as HPL-3, J15, Pit-1, Y2/51 and AN51 in MEG-A2 cells. The PMA-stimulation also induced expression of platelet peroxidase (PPO) in MEG-A2 cells on electromicroscopic observation. Proliferative responses to granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) or erythropoietin were observed, and the expression of GP IIb/IIIa was increased by stimulation with GM-CSF, IL-3, erythropoietin and interleukin-6 (IL-6). Protein S mRNA expression was seen in cultured cells on Northern blot analysis. Expression of platelet factor 4 mRNA was induced in PMA-stimulated cells, and a marked accumulation of protein was observed in the culture medium. In conclusion, a new cell line, MEG-A2, belongs to the relatively immature megakaryocytic lineage and has markedly increased megakaryocytic characteristics with PMA stimulation.
Model could work (2004)

entiated aggregation. Consequently, the detailed composition of clinical work is regarded as something that lies solely within the purview of the clinicians immediately involved. General acceptance of this opaque and ultimately privileged conception of clinical work reinforces the pernicious separation between clinicians and managers that continues to plague too many healthcare organisations. 14-17 In contrast, a pathway based model of clinical governance goes beyond the issues that are the focus of risk managers and quality coordinators. Based in a condition-specific conception of clinical work, it invites the people who do the work to define, describe, assess, and manage what they do as teams. It explicitly recognises the centrality of clinicians to the performance and organisation of clinical work and provides clinicians with a medium for integrating the clinical, resource, and organisational aspects of care. In doing so it provides a way for ensuring the responsible autonomy of clinicians. As all professions jointly and routinely enact the methods, structures, and processes outlined above, they will enfold the authority of a system of clinical self governance "into the soul" 18 and realise its developmental potential.
Thermoflavifilum aggregans gen. nov., sp. nov., a thermophilic and slightly halophilic filamentous bacterium from the phylum Bacteroidetes (2014)

A strictly aerobic, thermophilic, moderately acidophilic, non-spore-forming bacterium, strain P373(T), was isolated from geothermally heated soil at Waikite, New Zealand. Cells were filamentous rods, 0.2-0.4 µm in diameter and grew in chains up to 80 µm in length. On the basis of 16S rRNA gene sequence similarity, strain P373(T) was shown to belong to the family Chitinophagaceae (class Sphingobacteriia) of the phylum Bacteroidetes, with the most closely related cultivated strain, Chitinophaga pinensis UQM 2034(T), having 87.6 % sequence similarity. Cells stained Gram-negative, and were catalase- and oxidase-positive. The major fatty acids were i-15 : 0 (10.8 %), i-17 : 0 (24.5 %) and i-17 : 0 3-OH (35.2 %). Primary lipids were phosphatidylethanolamine, two unidentified aminolipids and three other unidentified polar lipids. The presence of sulfonolipids (N-acyl-capnines) was observed in the total lipid extract by mass spectrometry. The G+C content of the genomic DNA was 47.3 mol% and the primary respiratory quinone was MK-7. Strain P373(T) grew at 35-63 °C with an optimum temperature of 60 °C, and at pH 5.5-8.7 with an optimum growth pH of 7.3-7.4. NaCl tolerance was up to 5 % (w/v) with an optimum of 0.1-0.25 % (w/v). Cell colonies were non-translucent and pigmented vivid yellow-orange. Cells displayed an oxidative chemoheterotrophic metabolism. The distinct phylogenetic position and the phenotypic characteristics separate strain P373(T) from all other members of the phylum Bacteroidetes and indicate that it represents a novel species in a new genus, for which the name Thermoflavifilum aggregans gen. nov., sp. nov. is proposed. The type strain of the type species is P373(T) ( = ICMP 20041(T) = DSM 27268(T)).
Ion-exchange Resin Catalysis of the Knoevenagel Condensation of Ketones<sup>1</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIon-exchange Resin Catalysis of the Knoevenagel Condensation of Ketones1RICHARD W. HEIN, MELVIN J. ASTLE, and J. REID SHELTONCite this: J. Org. Chem. 1961, 26, 12, 4874–4878Publication Date (Print):December 1, 1961Publication History Published online1 May 2002Published inissue 1 December 1961https://pubs.acs.org/doi/10.1021/jo01070a022https://doi.org/10.1021/jo01070a022research-articleACS PublicationsRequest reuse permissionsArticle Views589Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
HATI: Hardware Assisted Thread Isolation for Concurrent C/C++ Programs (2014)

On a resource-sharing platform, running software subcomponents in isolation is critical to protect user's privacy and data security. In client-server applications, thread isolation is required to prevent private data that only belongs to certain threads from being read or modified by other unauthorized threads running in the same address space. However, the current programming languages (C/C++) and compilers do not provide such support for multi-threaded programs. In this paper, we propose HATI, a hardware assisted thread isolation approach. Different from software approaches, where both data access right setting and run-time monitoring of data objects access are embedded in applications and therefore result in significant dynamic memory usage and performance degradation, HATI leverages on-chip hardware modules to reduce the run-time validation time. It introduces much smaller memory overhead and very low performance degradation.
Vehicle sequencing based on evolutionary computation (2003)

A critical component for the efficient manufacturing of vehicles is an assembly scheduling tool that allows for the economic utilization of time and resources. From a computational perspective, vehicle scheduling can be characterized as a combinatorial constraint satisfaction and optimization problem that is NP-complete and for which exhaustive search methods are impractical. To date, heuristic approaches, based on a rank ordering of the relative importance of different types of constraints, have been used for the development of assembly sequences. Although these heuristic approaches have been beneficially applied, they are not easily adapted to incorporate new and more complicated scheduling constraints. We describe a practical and extensible approach for the development of assembly sequences based on methods of evolutionary computation (EC). We demonstrate that the resulting procedure, which we refer to as EC-VS, discovers desirable vehicle assembly sequences for complex problems in an efficient and effective fashion. A production version has been developed and is now deployed at a Ford vehicle assembly plant.