gebhart/patrepeval huggingface dataset:
Varistor Performance of ZnO‐Based Ceramics Related to Their Densification and Structural Development (1996)

Electrical potential barriers are often observed in ZnO‐based ceramics. Earlier studies on ZnO photoconduction have shown that the narrow regions, where the sintered grains have grown together, control the resistance of the entire sample. In those regions, the surface/volume ratio is sufficiently high for the acceptor concentration (which occurs because of adsorbed oxygen) to exceed the donor concentration inside the ZnO grains. More recent works have shown that Schottky barriers result from interface states because of the chemisorbed oxygen ion at the ZnO‐ceramic grain boundaries. The work reported in this paper involves the relationship between the densification of the microstructure and the varistor performance of ZnO ceramics. The emphasis of densification percentage as an indicator of the degree of sintering shows the desirability of continuity across ZnO grain boundaries, without the presence of voids or films of second phases, in optimizing varistor behavior. The effect of oxygen partial pressure on the development of varistor microstructure and electrical properties, as well the kinetics of grain growth, during the sintering process have been determined and are discussed.
Sequence, S–S Bridges, and Spectra of Bovine Transcobalamin Expressed in Pichia pastoris (1999)

Transcobalamin (TC) -encoding cDNA was isolated from a bovine mammary gland cDNA library. Hybridization of the cloned bovine TC-cDNA to RNA samples from bovine tissues showed that the most intensive synthesis of a TC positive 1.9-kilobase mRNA occurred in kidney, lymphatic nodes, and liver. Bovine TC was expressed in yeast Pichia pastoris, and the isolated recombinant protein showed cobalamin (Cbl) and receptor binding properties similar to TCs from other sources. Alignment of the related Cbl carriers (haptocorrins and intrinsic factors from other species) with bovine TC (414 residues) revealed four conservative clusters in the sequence (85-98, 137-147, 178-190, and 268-288), which may be responsible for Cbl binding. Three S-S bonds connected Cys residues 3-252, 98-294, and 147-190. Treatment with an S-S reducing agent caused liberation of Cbl from TC-Cbl. A significant change was observed in the TC-Cbl absorbance spectrum upon substitution of Co(2+)-coordinated H(2)O by azide. The reaction developed several orders of magnitude slower, and the spectral distortions were much stronger than those in free Cbl. This may be caused by significant deformation of the Cbl molecule and/or by its shielding when bound to TC.
Performance of Open Access Femtocell Networks with Different Cell-Selection Methods (2010)

Femtocell networks may significantly improve the capacity of next-generation cellular systems due to more efficient utilization of spectrum resources and better link qualities for mobile users. In this paper, we investigate the performance of open-access femtocell networks for different scenarios, where macrocell users are allowed to join a particular femtocell if it is preferable to do so. Both dedicated-channel and co-channel femtocell deployments are considered. We investigate different cell selection metrics, and argue that a capacity-based cell selection typically results in larger capacities for the users. Impact of wall penetration loss and how it relates to the capacities of indoor and outdoor users are also evaluated. Extensive downlink simulation results are provided to justify various system tradeoffs.
Variations of the Electrophoretic Protein Patterns of Heteroderidae (Nematodea : Tylenchida) Depending on the Developmental Stages of the Nematode and on the Growing Conditions of the Host Plants (1970)

Water soluble proteins of six nematode species of Heteroderidae (Heterodera glycines, H. oryzae, Meloidogyne hapla, M. incognita, M. mali, Meloidogyne (=Hypsoperine) sp.) were investigated by the disc electrophoresis technique. They showed distinct and characteristic protein patterns. However, their protein patterns varied according to their host plant species and the developmental stages of the nematodes. A common tendency found in H. glycines, M. hapla, and M. incognita was intensive stainability of faster-moving protein bands as the nematodes became senescent or when they grew on the host plants the growth of which was retarded. This was also observed in the root-knot nematodes which were treated with D-D fumigation. Zymograms of esterase, acid phosphatase, and lactate dehydrogenase isozymes seemed to vary more greatly with the developmental stages of the nematodes than with the difference in the growing conditions of the host plants. The faster-moving bands of lactate dehydrogenase isozymes in M. incognita became more intensive as the females became senescent.
Contamination of a multiple-use suction catheter in a closed-circuit system compared to contamination of a disposable, single-use suction catheter. (1986)

Fourteen different pathogens or potential pathogens were recovered, in numbers of 2 x 10(1) to 2 x 10(7)colony-forming units. The greatest number of colonies was most often recovered from the sputum specimen, and statistical analysis showed no differences in rate or magnitude of contamination between M-U and S-U catheters.(ABSTRACT TRUNCATED AT 250 WORDS)
Spectroscopy and Electrochemistry of Ruthenium-Modified Nucleic Acids:  Design of a Novel Metal-Binding Nucleoside (2000)

Electron transfer (ET) reactions through DNA have been the\nsubject of numerous investigations due to the implications for light-induced DNA damage and the quest for understanding long-range ET events in biological molecules. An important objective in this area continues to be the facile and site-specific incorporation of metal complexes into DNA. While recent work has focused on nucleobasic and nonnucleosidic sites for the attachment of high-potential complexes, our efforts have concentrated on the ribose ring (to minimize structural perturbations) as the incorporation\nsite for both high- and low-potential metal complexes.
Podemos hablar de una pedagogía lasaliana hoy (2011)

Se propone una discusion abierta hacia la problematizacion de la pedagogia lasaliana
como discurso que comporta una racionalidad cientifica consistente. Mas que dar
respuestas, el autor plantea preguntas y proporciona criterios para incentivar una relectura
de la tradicion educativa heredada desde hace mas de trescientos anos. Apoyandose en la
discusion abierta sobre el estatuto epistemologico de la pedagogia, propone comprender
lo lasaliano a partir de la consideracion de una racionalidad cientifica comprometida con
la construccion de proyectos historicos, con una clara intencionalidad humanizadora
desde un horizonte de fe. Las preguntas quedan abiertas y se invita a continuar en el
debate.
Plate auto-level system for fused deposition modelling (FDM) 3D printers (2017)

Purpose The purpose of this paper is to present a solution for the levelling plate of fused deposition modelling (FDM) additive manufacturing (AM) systems. This automatic levelling system is presented as an evolution of actual systems, which uses a new ultrasound sensing system. Design/methodology/approach After obtaining a prototype, different tests were conducted for getting a system which solves the level plate problem and can be mounted in any FDM AM machine. Several benchmark models were obtained and compared with current equipment concepts for the validity of the product. Findings All tests were performed with high accuracy, enabling the production of geometries that could not have been achieved without this novel system. Practical implications This development will enable experienced users to set aside the problems of calibration and focus on the purpose of this type of machines, making prototypes. Originality/value A system architecture has been developed and integrated into an open hardware AM system, allowing real-time adjustment of the plate during each layer, thus eliminating the need of levelling the plate, allowing to achieve easier printing, and without increasing the cost significantly.
Binding of K<sub>ATP</sub> channel modulators in rat cardiac membranes (1998)

1. The binding of [3H]-P1075, a potent opener of adenosine-5'-triphosphate-(ATP)-sensitive K+ channels, was studied in a crude heart membrane preparation of the rat, at 37 degrees C. 2. Binding required MgATP. In the presence of an ATP-regenerating system, MgATP supported [3H]-P1075 binding with an EC50 value of 100 microM and a Hill coefficient of 1.4. 3. In saturation experiments [3H]-P1075 binding was homogeneous with a KD value of 6+/-1 nM and a binding capacity (Bmax) of 33+/-3 fmol mg(-1) protein. 4. Upon addition of an excess of unlabelled P1075, the [3H]-P1075-receptor complex dissociated in a mono-exponential manner with a dissociation rate constant of 0.13+/-0.01 min(-1). If a bi-molecular association mechanism was assumed, the dependence of the association kinetics on label concentration gave an association rate constant of 0.030+/-0.003 nM(-1) min(-1). From the kinetic experiments the KD value was calculated as 4.7+/-0.6 nM. 5. Openers of the ATP-sensitive K+ channel belonging to different structural classes inhibited specific [3H]-P1075 binding in a monophasic manner to completion; an exception was minoxidil sulphate where maximum inhibition was 68%. The potencies of the openers in this assay agree with published values obtained in rat cardiocytes and are on average 3.5 times lower than those determined in rat aorta. 6. Sulphonylureas, such as glibenclamide and glibornuride and the sulphonylurea-related carboxylate, AZ-DF 265, inhibited [3H]-P1075 binding with biphasic inhibition curves. The high affinity component comprised about 60% of the curves with the IC50 value of glibenclamide being approximately 90 nM; affinities for the low affinity component were in the microM concentration range. The fluorescein derivative, phloxine B, showed a monophasic inhibition curve with an IC50 value of 6 microM, a maximum inhibition of 94% and a Hill coefficient of 1.5. 7. It is concluded that binding studies with [3H]-P1075 are feasible in rat heart membranes in the presence of MgATP and of an ATP-regenerating system. The pharmacological profile of the [3H]-P1075 binding sites in the cardiac preparation, which probably contains sulphonylurea receptors (SURs) from cardiac myocytes (SUR2A) and vascular smooth muscle cells (SUR2B), differs from that expected for SUR2A and SUR2B.
Cloning of an Intrinsic Human TFIID Subunit That Interacts with Multiple Transcriptional Activators (1995)

TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs). The TAFs in TFIID are essential for activator-dependent transcription. The cloning of a complementary DNA encoding a human TFIID TAF, TAFII55, that has no known homolog in Drosophila TFIID is now described. TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain. The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110. Thus, this human TFIID TAF may be a co-activator that mediates a response to multiple activators through a distinct mechanism.
Mucopolysaccharidosis VI (2010)

Mucopolysaccharidosis VI (MPS VI) is a lysosomal storage disease with progressive multisystem involvement, associated with a deficiency of arylsulfatase B leading to the accumulation of dermatan sulfate. Birth prevalence is between 1 in 43,261 and 1 in 1,505,160 live births. The disorder shows a wide spectrum of symptoms from slowly to rapidly progressing forms. The characteristic skeletal dysplasia includes short stature, dysostosis multiplex and degenerative joint disease. Rapidly progressing forms may have onset from birth, elevated urinary glycosaminoglycans (generally >100 microg/mg creatinine), severe dysostosis multiplex, short stature, and death before the 2nd or 3rd decades. A more slowly progressing form has been described as having later onset, mildly elevated glycosaminoglycans (generally <100 microg/mg creatinine), mild dysostosis multiplex, with death in the 4th or 5th decades. Other clinical findings may include cardiac valve disease, reduced pulmonary function, hepatosplenomegaly, sinusitis, otitis media, hearing loss, sleep apnea, corneal clouding, carpal tunnel disease, and inguinal or umbilical hernia. Although intellectual deficit is generally absent in MPS VI, central nervous system findings may include cervical cord compression caused by cervical spinal instability, meningeal thickening and/or bony stenosis, communicating hydrocephalus, optic nerve atrophy and blindness. The disorder is transmitted in an autosomal recessive manner and is caused by mutations in the ARSB gene, located in chromosome 5 (5q13-5q14). Over 130 ARSB mutations have been reported, causing absent or reduced arylsulfatase B (N-acetylgalactosamine 4-sulfatase) activity and interrupted dermatan sulfate and chondroitin sulfate degradation. Diagnosis generally requires evidence of clinical phenotype, arylsulfatase B enzyme activity <10% of the lower limit of normal in cultured fibroblasts or isolated leukocytes, and demonstration of a normal activity of a different sulfatase enzyme (to exclude multiple sulfatase deficiency). The finding of elevated urinary dermatan sulfate with the absence of heparan sulfate is supportive. In addition to multiple sulfatase deficiency, the differential diagnosis should also include other forms of MPS (MPS I, II IVA, VII), sialidosis and mucolipidosis. Before enzyme replacement therapy (ERT) with galsulfase (Naglazyme), clinical management was limited to supportive care and hematopoietic stem cell transplantation. Galsulfase is now widely available and is a specific therapy providing improved endurance with an acceptable safety profile. Prognosis is variable depending on the age of onset, rate of disease progression, age at initiation of ERT and on the quality of the medical care provided.
Safety and Biological Activity of Repeated Doses of Recombinant Human Flt3 Ligand in Patients with Bone Scan-Negative Hormone-Refractory Prostate Cancer (2004)

FL was well tolerated. FL consistently produced an increase in DC count without any evidence of decreasing response with continued exposure. The expansion of DCs and the slowing of PSA velocity after administration of FL suggest potential clinical applications in the immunotherapy of prostate cancer.
Recent Advances in Microcolumn Liquid Chromatography (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRecent Advances in Microcolumn Liquid ChromatographyMilos NovotnyCite this: Anal. Chem. 1988, 60, 8, 500A–510APublication Date (Print):April 15, 1988Publication History Published online30 May 2012Published inissue 15 April 1988https://pubs.acs.org/doi/10.1021/ac00159a718https://doi.org/10.1021/ac00159a718research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oral Absorption and Bioavailability of Tea Catechins (2000)

The absorption characteristics and oral bioavailability of three tea catechins, namely (-)-epicatechin (EC), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin gallate (EGCG), were assessed in this study. Male Sprague Dawley rats (210-230 g) received either an intravenous (i.v. 50 mg/kg) or oral (5000 mg/kg) dose of decaffeinated catechin-fraction containing EC (5%), EGCG (50%), and ECG (13%). Concentrations of the compounds in plasma, urine, and feces were measured using HPLC. A non-compartmental approach was employed for pharmacokinetic analysis. Results indicated that maximum plasma concentrations for the catechins (15-112 micrograms/ml) were achieved at 2 h post-oral dosing and the apparent volume of distribution (Vd/F) ranged from 30 to 63 l/kg. Absolute bioavailability (F) of EC, EGCG, and ECG was assessed to be 0.39, 0.14, and 0.06, respectively. Estimates of terminal elimination half-life (t1/2, lambda z) of the catechins after oral dosing were 451-479 min and were 1.4-10 fold longer than those observed for the i.v. dosing. The discrepancy in terminal elimination and low rate and extent of absorption indicated the possibility of flip-flop kinetics. Respective urinary recoveries were 0.17-4.72% and 2.11-14.2% after oral and i.v. dosing. In conclusion, the low systemic availability of tea catechins observed could be a result of slow absorption, high first pass effect, and wide tissue distribution.
Isolation and Characterization of Collagen from the Body Wall of Sea Cucumber <i>Stichopus monotuberculatus</i> (2015)

To exploit a new collagen resource from the body wall of tropical sea cucumber, pepsin-solubilized collagen of Stichopus monotuberculatus (PSC-Sm) was isolated and characterized with UV-vis spectra, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), amino acid composition, enzyme-digested peptide maps, Fourier transform infrared spectroscopy (FTIR), maximum transition temperature (Tm ), and solubilities. The maximum absorbance of PSC-Sm was exhibited at 218 nm in UV-vis spectra. The triple helical structure and activity of PSC-Sm could be indicated by FTIR. SDS-PAGE showed that the triple helix of PSC-Sm was formed as (α1 )3 by 3 α1 chain homologous with molecular weight of 137 kDa. The Tm of PSC-Sm and calf skin collagen (CSC) were 30.2 and 35.0 ºC, respectively, which consistent with the result of FTIR that CSC contained more stable triple-helix than PSC-Sm. Peptide maps were different between PSC-Sm and CSC, indicating the differences in their amino acid compositions and sequences. The maximum and minimum solubilities of PSC-Sm were observed at pH 2.0 and 4.0, respectively. A sharp decrease in solubility appeared when NaCl concentration was between 3% and 5%. These results showed that collagen from S. monotuberculatus had the type I collagen characteristics and good thermal stability, and therefore, it could be used as an alternative resource of collagen.
Expression of the Rous Sarcoma Virus <i>pol</i> Gene by Ribosomal Frameshifting (1985)

The pol gene of Rous sarcoma virus is positioned downstream of the gag gene in a different, briefly overlapping reading frame; nevertheless, the primary translation product of pol is a gag-pol fusion protein. Two mechanisms, ribosomal frameshifting and RNA splicing, have been considered to explain this phenomenon. The frameshifting model is supported by synthesis of both gag protein and gag-pol fusion protein in a cell-free mammalian translation system programmed by a single RNA species that was synthesized from cloned viral DNA with a bacteriophage RNA polymerase. Under these conditions, the ratio of the gag protein to the fusion protein (about 20 to 1) is similar to that previously observed in infected cells, the frameshifting is specific for the gag-pol junction, and it is unaffected by large deletions in gag. In addition, synthesis of the fusion protein is ten times less efficient in an Escherichia coli cell-free translation system and cannot be explained by transcriptional errors or in vitro modification of the RNA. Ribosomal frameshifting may affect production of other proteins in higher eukaryotes, including proteins encoded by several retroviruses and transposable elements.
Low cost fiber optic rate sensor inertial measurement unit (2002)

AlliedSignal Precision Products is developing a miniaturized low-cost Inertial Measurement Unit (IMU) with tactical performance which can be utilized in gun launched munitions, greater than 12000 g shock, and severe environmental conditions. The minimum configuration (MC) FOG implemented with a Silicon MEMS accelerometer provides the technology for achieving a very low cost IMU. In this paper, we will present the sensor selection, and IMU architecture and calibration approach of the IMU and illustrate the inherent advantages of this unique design. We will describe our modeling aid performance design approach and will present breadboard test results. Additionally, a calibration method based on parametric estimation technique was developed. The calibration method does not require repeated calibration procedures, thus significantly reducing IMU manufacturing cost and enabling high IMU production rates. Results will be reported on IMU performance verification, including bias, scale factor, misalignment and sensor non-orthogonality, under various environmental test conditions.
Organized 3D-alkyl imidazolium ionic liquids could be used to control the size of in situ generated ruthenium nanoparticles? (2009)

The synthesis of ruthenium nanoparticles, RuNPs from the organometallic complex (η4-1,5-cyclooctadiene)(η6-1,3,5-cyclooctatriene)ruthenium(0), Ru(COD)(COT) in various imidazolium derived ionic liquids, ILs: [RMIm][NTf2] (R = CnH2n + 1 with n = 2; 4; 6; 8; 10), and [R2Im][NTf2] (RBu) and [BMMIm][NTf2] has been performed, under 0.4 MPa of H2, at 25 °C or at 0 °C with or without stirring. A relationship between the size of IL non-polar domains calculated by molecular dynamics simulation and the RuNP size measured by TEM has been found, suggesting that the phenomenon of crystal growth is probably controlled by the local concentration of Ru(COD)(COT) and consequently is limited to the size of the non-polar domains. Moreover, the rigid 3D organization based on C2–H⋯anion bonding and chosen experimental conditions, could explain the non-aggregation of RuNPs.
计算机网络通信安全中数据加密技术分析 (2020)

在社会经济不断发展的过程中，我国的科技研发水平，也在不断地提高。当前计算机网络技术的应用范围，变得越来越广，对居民的日常生产生活，产生了巨大的影响。但是计算机网络技术在发展时，因为网络的过度开放等问题。导致居民在获取大量的数据信息资源时，会遭受信息数据的窃听和盗取等问题。导致网络环境的安全问题，变得更加严重，而且引起了社会各界人士的广泛关注。所以，在进行计算机网络通信技术应用时，必须保证技术的应用安全，通过数据加密等技术的应用，营造一个更加安全的网络环境。本文就计算机网络和通信安全中的数据加密技术应用进行相关的分析和探讨。
Determination of Triclosan as Its Pentafluorobenzoyl Ester in Human Plasma and Milk Using Electron Capture Negative Ionization Mass Spectrometry (2006)

A sensitive method for the determination of triclosan in plasma and milk is presented. Following hydrolysis of possible conjugates, triclosan is extracted with n-hexane/acetone, partitioned into alcoholic potassium hydroxide, and converted into its pentafluorobenzoyl ester. After sulfuric acid cleanup, sample extracts are analyzed by gas chromatography/electron capture negative ionization mass spectrometry. The limit of quantification was 0.009 ng/g for a 5-g plasma sample and 0.018 ng/g for a 3-g milk sample. The coefficient of variation for the method was 6%. The method was tested on more than 70 human plasma and milk samples, of which all plasma samples and more than half of the milk samples were above the limit of quantification. The presented method has lowered the limit of quantification for triclosan in human matrixes significantly as compared to previous methods and makes possible the analysis of triclosan in humans under normal exposure conditions.