gebhart/patrepeval huggingface dataset:
Genetic identification of a common collagen disease in Puerto Ricans via identity-by-descent mapping in a health system (2017)

Achieving confidence in the causality of a disease locus is a complex task that often requires supporting data from both statistical genetics and clinical genomics. Here we describe a combined approach to identify and characterize a genetic disorder that leverages distantly related patients in a health system and population-scale mapping. We utilize genomic data to uncover components of distant pedigrees, in the absence of recorded pedigree information, in the multi-ethnic Bio<i>Me</i> biobank in New York City. By linking to medical records, we discover a locus associated with both elevated genetic relatedness and extreme short stature. We link the gene, <i>COL27A1</i>, with a little-known genetic disease, previously thought to be rare and recessive. We demonstrate that disease manifests in both heterozygotes and homozygotes, indicating a common collagen disorder impacting up to 2% of individuals of Puerto Rican ancestry, leading to a better understanding of the continuum of complex and Mendelian disease.
Design and verification of monopole patch antenna systems to generate orbital angular momentum waves (2017)

Monopole patch antenna systems, which can generate orbital angular momentum (OAM) waves at 2.4GHz, are proposed in this paper. The proposed antenna systems have advantages of simple planar structure and small size of antenna element. Design, simulation, fabrication and measurement of the proposed antenna systems are presented. Two feeding networks, which constitute the proposed antenna systems with monopole patch antenna array, are designed to generate modes 1 and 2 of OAM waves. The antenna systems for both modes are shown to be effective in generating OAM waves of modes 1 and 2 from both simulation and three types of measurement: radiation pattern, phase distribution and phase gradient. Simulation and measurement results of radiation pattern and phase distribution have shown very close results. Phase gradient measurement results has verified that the generated waves from the antenna systems are indeed OAM waves.
Efficient Synthesis of Tricarbonyliron−Diene Complexes Development of an Asymmetric Catalytic Complexation (2000)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEfficient Synthesis of Tricarbonyliron−Diene Complexes Development of an Asymmetric Catalytic Complexation†Hans-Joachim KnölkerView Author Information Institut für Organische Chemie, Universität Karlsruhe, Richard-Willstätter-Allee, 76131 Karlsruhe, Germany Cite this: Chem. Rev. 2000, 100, 8, 2941–2962Publication Date (Web):July 12, 2000Publication History Received10 March 2000Published online12 July 2000Published inissue 1 August 2000https://pubs.acs.org/doi/10.1021/cr990267khttps://doi.org/10.1021/cr990267kresearch-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1632Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Chemical reactions,Complexation,Ligands,Reagents Get e-Alerts
A wide-band electrically small superdirective array (1982)

The characteristics and a design procedure for an electrically small superdirective array with a 3-to-1 pattern bandwidth are presented. Theoretical patterns are compared with measurements. Trade-offs between array size, tolerances, directivity, and signal strength are discussed.
MIB-1 proliferative activity in invasive breast cancer measured by image analysis. (1996)

The MIB-1 proliferation index is a reliable, practical and useful method of measuring proliferative activity and is an important predictor of clinical behaviour.
Use of a reverse‐transcriptase polymerase chain reaction for monitoring the shedding of feline coronavirus by healthy cats (2001)

The pattern of shedding of feline coronavirus (FCoV) was established in 155 naturally infected pet cats from 29 households over periods of up to five years. Viral RNA was detected in faeces by reverse-transcriptase PCR (RT-PCR), and plasma antiviral antibodies by immunofluorescence. The cats rarely shed FCoV in their saliva. Three patterns of FCoV shedding were observed. Eighteen of the cats shed virus continuously, so were persistent, and possibly lifelong, carriers; none of them developed feline infectious peritonitis. Fifty-six cats ceased shedding virus, although they were susceptible to reinfection, and 44 shed intermittently or were being continuously reinfected. Four of the cats were resistant to infection. Seventy-three per cent of the virus shedding episodes lasted up to three months and 95 per cent up to nine months. There was a correlation between shedding and antibody titre but the cats could remain seropositive for some time after they had ceased shedding virus. One-off testing for FCoV by RT-PCR is inappropriate. Identification of longterm carriers requires that a positive result be obtained by RT-PCR on faecal samples for at least eight consecutive months. A cat should be shown to be negative over five months, or to have become seronegative, to ensure that it has ceased shedding virus.
Self‐Folding: Self‐Folding Using Capillary Forces (Adv. Mater. Interfaces 5/2020) (2020)

Favorable scaling of capillary forces at small sizes makes them attractive for micro- and nanoscale assembly. In article number 1901677, Kam Sang Kwok, Qi Huang, Massimo Mastrangeli, and David H. Gracias review design principles, theoretical and experimental advances, and applications of 3D assembly by folding, bending, and curving using capillary forces.
A fully digital feedforward MSK demodulator with joint frequency offset and symbol timing estimation for burst mode mobile radio (1993)

A strictly feedforward demodulator structure for minimum shift keying (MSK) modulation with joint nondata-aided symbol clock and frequency offset estimation is presented. Due to its feedforward operation, clock synchronization and frequency offset compensation are hang-up free, and the demodulator is well suited for a digital implementation. The sampled baseband signal is passed through a nonlinearity and smoothed by a digital filter. The magnitude of the filter output directly drives the clock recovery process. The phase of the smoothed signal is an estimate of the carrier frequency offset and is used for offset compensation. Following synchronization, the signal is demodulated by differentially coherent detection. The performance of the demodulator is assessed for the AWGN and the Rayleigh flat and frequency-selective fading channel by computer simulations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Comparison of different methods for data-driven respiratory gating of PET data (2013)

Respiratory movement degrades image quality in PET/CT. The first step in correcting for movement is to gate the data into different motion states. In current practice, the gating is based on information from external devices that measure physical parameters such as the chest position. Various groups have proposed methods to extract a gating signal out of the PET data. Here we compare methods using PCA, Laplacian Eigenmaps, Spectral Analysis and sensitivity. We test the methods on clinical PET list mode data for different tracers. We evaluate correlation with the chest position as measured by the Varian RPM system, and stability under increased noise in the PET data, both by reducing counts and reducing total duration. We also compare SUVmax and lesion displacement when gating the PET data based on the signals extracted by the different methods.
Multiple mRNA species code for the catalytic subunit of the cAMP‐dependent protein kinase from LLC‐PK<sub>1</sub> cells (1987)

We present evidence for the existence of two forms of the catalytic (C) subunit of the cAMP-dependent protein kinase. A lambda gt-11 cDNA library constructed from poly(A)-rich RNA from the porcine kidney cell line, LLC-PK1, was screened using a 1.5-kb EcoRI fragment from a bovine cDNA for the C subunit. Two independent classes of cDNAs were identified on the basis of partial restriction map and sequence data. These two cDNAs, lambda CAT4 and lambda CAT3, apparently encode two forms of C subunit designated C alpha and C beta, respectively. The nucleotide sequence of the C alpha and C beta cDNAs revealed differences in the coding region and particularly in the 3' untranslated region. However, the deducted amino acid sequences of C alpha and C beta subunits were 96% homologous to the sequences so far determined. Specific probes from the 3' coding region of the two cDNA species were used to investigate C subunit mRNA expression in LLC-PK1 cells. Northern analysis showed a major mRNA species of 2.8 kb with the C alpha probe while the C beta probe detected two mRNA species of 5.0 kb and 3.8 kb. These data were supported by genomic blot analysis which showed distinct hybridization patterns with either the C alpha or C beta probes. All the available evidence suggests that at least two distinct genes encode the C subunit which are expressed in LLC-PK1 cells.
New PDLC-Films Doped by Black Dye (2001)

Abstract Dichroic-dye doped PDLC films were obtained by polymerization-induced phase separation method with two types of dichroic dyes, including a black mixture. The electro-optic characteristics of these films were investigated for different concentrations of liquid crystal in polymer matrix. A strong memory effect was found in such systems, depending on LC concentration and on the type of dichroic dye.
Thiation of Nucleosides. I. Synthesis of 2-Amino-6-mercapto-9-β-D-ribofuranosylpurine (“Thioguanosine”) and Related Purine Nucleosides<sup>1</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThiation of Nucleosides. I. Synthesis of 2-Amino-6-mercapto-9-β-D-ribofuranosylpurine ("Thioguanosine") and Related Purine Nucleosides1Jack J. Fox, Iris Wempen, Alexander Hampton, and Iris L. DoerrCite this: J. Am. Chem. Soc. 1958, 80, 7, 1669–1675Publication Date (Print):April 1, 1958Publication History Published online1 May 2002Published inissue 1 April 1958https://pubs.acs.org/doi/10.1021/ja01540a041https://doi.org/10.1021/ja01540a041research-articleACS PublicationsRequest reuse permissionsArticle Views621Altmetric-Citations167LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Additive manufacturing of Ti-6Al-4V alloy components for spacecraft applications (2013)

In the last two decades, there have been significant advancements in the field of additive manufacturing of Ti-6Al-4V alloy and other metallic components for aerospace applications. Generally, metallic brackets used in spacecraft applications are machined from the bulk-rolled or extruded products of the specific alloy. Using Arcam's electron beam melting-based (EBM) additive manufacturing process, several Ti-6Al-4V alloy brackets were produced, finish machined, and tested to determine their mechanical properties compared to the bulk alloy. This paper describes the use of several EBM-processed Ti-6Al-4V brackets on the Juno spacecraft. Initially, the three-dimensional (3-D) CAD model of each of the bracket drawings was developed to include slightly excess surface layers for machining to a smooth surface finish. Multiple parts were built simultaneously in the available chamber size. Preliminary cost and benefit analysis was also performed to assess the merit of using additive manufacturing for future spacecraft components. Under the same EBM processing conditions, multiple Ti-6Al-4V rod specimens were built to prepare the subscale test specimens for mechanical property measurements. Results of these tests indicated that the average material properties were quite comparable to the wrought alloy. Each of the manufactured parts was inspected using a nondestructive test method to ensure the quality of the finished product. A few component-level destructive tests validated that the component had adequate margin of safety to survive operational load conditions. Based on these results, several Ti-6Al-4V brackets were used on the Juno spacecraft which was launched in August 2011. Successful insertion of EBM-processed parts should pave the way for the use of Additive manufacturing in future spacecraft components.
A New Paradigm for Tissue Diagnostics: Tools and Techniques to Standardize Tissue Collection, Transport, and Fixation (2018)

This review highlights the beneficial aspects of standardizing tissue collection, fixation, and monitoring. In addition, a prototype system is introduced that could help standardize these processes and is compatible with use directly in the OR and from remote sites.
Single Sequential Turbocharger: A New Boosting Concept for Ultra-Low Emission Diesel Engines (2008)

<div class="htmlview paragraph">As turbocharged diesel engines have evolved to higher brake mean effective pressure (BMEP) levels, with ultra-low levels of regulated emissions, it has become increasingly difficult to match the turbine and compressor in conventional turbocharger and achieve the desired level of performance and responsiveness. Emissions regulations result in the use of ultra-high levels of Exhaust Gas Recirculation (EGR) to control NOx and Diesel Particulate Filters (DPF) to control soot and particulate emissions. These technologies exacerbate the compressor/turbine matching issue by reducing the turbine corrected flow to as little as half the compressor corrected flow.</div> <div class="htmlview paragraph">A new design concept is presented in this paper that significantly improves the performance of the <u>turbine</u> by changing the work/speed relationship of the <u>compressor</u>. This is accomplished by using a double-sided compressor and results in a secondary benefit of improved flow range of the compressor, achieved by stalling one of the compressor wheels. Due to the improved range of the compressor, the backward curvature can be reduced, which improves the pressure ratio capability.</div> <div class="htmlview paragraph">When combined with a ball bearing cartridge, this concept results in a single turbo with a double-digit improvement of turbine efficiency, a high pressure, wide range compressor, in a small, compact package capable of providing performance unattainable in a conventional turbocharger configuration.</div>
Standardized Procedure for Measuring Foaming Properties of Three Proteins, A Collaborative Study (1990)

ABSTRACT A collaborative study involving nine laboratories was conducted over four years to evaluate a rapid, simple and reliable whipping method for measuring overrun and foam stability. Effectiveness of the method was assessed by measuring the characteristics of foams formed by three protein solutions (5%): sodium caseinate, milk protein isolate, and egg white protein; identifying and systematically eliminating sources of variability. Major sources of variability were protein dispersing technique, the mixer, and the care exercised by the operator during sampling and weighing. The method detected differences in foam stability between egg white, casein and milk protein isolate (pooled SD = 4.5) using different mixers.
Shmoo plotting: the black art of IC testing (2002)

Modern IC testing has developed many different techniques each with specific targets for improving quality and controlling the process to improve the yield over the life time of the product. Shmoo plotting of digital ICs is part of the early product characterisation procedures intended to establish that the design is stable within the process and can be manufactured with virtually zero yield loss, except for spot defects. In this sense Shmoo plotting verifies that the IC has been implemented to six-sigma design principles, or better. It also allows the wafer/batch monitoring parameters to be accurately established for the product. For the vast majority of ICs for which no performance binning is performed it avoids testing all of the parts in production for process variations. This is economically essential for high volume production because testing a device for process variations expressly implies functional testing, instead of simple defect oriented testing such a scan testing or IDDQ. Thus, knowledge gained from Shmoo plotting can be used to optimize the process, design and final test program.
Regenerative PbS and CdS Quantum Dot Sensitized Solar Cells with a Cobalt Complex as Hole Mediator (2009)

Metal sulfide (PbS and CdS) quantum dots (QDs) were prepared over mesoporous TiO2 films by improved successive ionic layer adsorption and reaction (SILAR) processes. The as-prepared QD-sensitized electrodes were combined with a cobalt complex redox couple [Co(o-phen)3]2+/3+ to make a regenerative liquid-type photovoltaic cell. The optimized PbS QD-sensitized solar cells exhibited promising incident photon-to-current conversion efficiency (IPCE) of over 50% and an overall conversion efficiency of 2% at 0.1 sun in a regenerative mode. The overall photovoltaic performance of the PbS QD-sensitized cells was observed to be dependent on the final turn of the SILAR process, giving a better result when the final deposition was Pb2+, not S2-. However, in the case of CdS QD-sensitized cells, S2- termination was better than that of Cd2+. The cobalt complex herein used as a regenerative redox couple was found to be more efficient in generating photocurrents from PbS QD cells than the typical hole scavenger Na2S in a three-electrode configuration. The CdS-sensitized cell with this redox mediator also showed better defined current-voltage curves and an IPCE reaching 40%.
Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. (1991)

Antibodies producing an unusual immunofluorescent pattern were identified in the sera of patients with diverse autoimmune features. This pattern was characterized by the presence of up to six round discrete nuclear bodies in interphase cell nuclei. Immunoblotting analysis showed that these sera recognized an 80-kD nuclear protein, and affinity-purified anti-p80 antibody from the protein band reproduced the fluorescent staining of nuclear bodies. Colloidal gold immunoelectron microscopy showed that the affinity-purified anti-p80 antibody recognized the coiled body, an ultramicroscopic nuclear structure probably first described by the Spanish cytologist Ramon y Cajal. Five cDNA clones were isolated from a MOLT-4 cell lambda gt-11 expression library using human antibody and oligonucleotide probes. The longest cDNA insert was 2.1 kb and had an open reading frame of 405 amino acids. A clone encoding a 14-kD COOH-terminal region of the protein was used for expression of a beta-galactosidase fusion protein. An epitope was present in this COOH-terminal 14-kD region, which was recognized by 18 of 20 sera with anti-p80 reactivity, and affinity-purified antibody from the recombinant protein also reacted in immunofluorescence to show specific staining of the coiled body. This is the first demonstration and molecular cloning of a protein that appears to have particular identification with the coiled body, and it was designated p80-coilin. Autoantibody to p80-coilin may be useful for the elucidation of the structure and function of the coiled body, and the availability of a cDNA sequence could be helpful in further studies to clarify the clinical significance of this autoantibody response.
Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice (2013)

These results suggest that airway exposure to engineered SNP could enhance allergen sensitization and foster greater manifestation of allergic airway disease upon secondary allergen exposures. Whereas SNP caused innate immune responses at high doses in non-allergic mice, the adjuvant effects of SNP were found at lower doses in allergic mice and were Th2/Th17 related. In conclusion, these findings in mice suggest that individuals exposed to SNP might be more prone to manifest allergic airway disease, due to adjuvant-like properties of SNP.
EFFECTS OF 1,25‐DIHYDROXYCHOLECALCIFEROL ON <sup>47</sup>CALCIUM ABSORPTION IN POST‐MENOPAUSAL OSTEOPOROSIS (1979)

Measurement of 47Calcium absorption was performed on eleven women with post-menopausal osteoporosis. The study was repeated after 10 days treatment with 1 microgram daily of 1,25(OH)2D3. These patients showed a statistically significant improvement of fractional calcium absorption that was inversely correlated to the basal values. The prompt improvement of the intestinal calcium transport in post-menopausal osteoporotic women, a few days after the administration of physiological doses of 1,25(OH)2D3, suggests that these patients synthesize inappropriately small amounts of 1,25(OH)2D3 because of their oestrogen deficiency. This could be an important pathogenetic factor in post-menopausal osteoporosis, as the efficiency of the adaptation of calcium absorption to low calcium intakes is dependent on 1,25(OH)2D3.
Millimeter-wave front-end integration concept using beam-switched lens antenna (2016)

A millimeter-wave mobile communication base-station of compact form factor is discussed which could provide tens of users within a range of several tens of meters with data-rates in excess of ten gigabit per second (Gbps) for each user (that is, aggregate wireless throughput of the cell well above 100 Gbps). The discussion focuses on hardware aspects in order to identify key technologies and challenges. Innovative techniques like gradient-index lens antenna and chip-to-antenna coupling by means of spherical dielectric resonator make the system realistic using straightforward improvements of today's technology.