gebhart/patrepeval huggingface dataset:
Efficient Encapsulation of Plasmid DNA in pH‐Sensitive PMPC–PDPA Polymersomes: Study of the Effect of PDPA Block Length on Copolymer–DNA Binding Affinity (2010)

We report the self-assembly of a series of amphiphilic diblock copolymers comprising a biocompatible, hydrophilic block, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and a pH-sensitive block, poly(2-(diisopropylamino)ethyl methacrylate) (PDPA), into a dispersion of colloidally stable, nanometer-sized polymersomes at physiological pH and salt concentration. The pH-sensitivity of the PDPA block affords the electrostatic interaction of these block copolymers with nucleic acids at endocytic pH, as a result of the protonation of its tertiary amine groups at pH values below its pK(a). Herein we investigate the effect of PDPA block length on the binding affinity of the block copolymer to plasmid DNA.
Exploration of Potential Prodrugs of RWJ‐445167, an Oxyguanidine‐based Dual Inhibitor of Thrombin and Factor Xa (2006)

Compound 2 (RWJ-445167; 3DP-10017), a dual inhibitor of thrombin and factor Xa, was advanced into human clinical studies. However, its oral bioavailability in humans proved to be below acceptable limits. To address this issue, we explored a prodrug approach involving numerous guanidine derivatives. Prodrug candidates of classes A (carbamate derivatives), B (imidate derivatives), and C (alkyl and acyl derivatives), compounds 3-6, were synthesized and evaluated for anticoagulant activity at 2 h after oral administration to rats. In comparison to the parent drug (2), little worthwhile improvement was observed for the prodrug candidates.
Trenimon: Biochemical, physiological and genetic effects on cells and organisms (1979)

The trifunctional alkylating mutagen Trenimon interferes with the genetic material of a variety of organisms and test systems with respect to the induction of point and chromosomal mutations, sister-chromatid exchanges, recombination phenomena and phage induction. Beneath these mutagenic effects several biochemical and cell physiological aspects have been investigated. In this review we discuss chemical and cell physiological effects of Trenimon, aspects of cancer therapy with Trenimon and genetic effects induced by Trenimon. The available data on mutagenic effects of Trenimon are presented according to organisms or test systems. A short discussion on a possible genetic load by therapy with Trenimon in man concludes this review. DNA damage, especially the induction of cross-linkings, seems to represent the common reason for most of the described effects of Trenimon on cells and organisms.
A Model for Mortality Rates and a Test of Fit for the Gompertz Force of Mortality (1973)

R. L. Prentice, A. El Shaarawi, A Model for Mortality Rates and a Test of Fit for the Gompertz Force of Mortality, Journal of the Royal Statistical Society. Series C (Applied Statistics), Vol. 22, No. 3 (1973), pp. 301-314
Process control based on quadrupole mass spectrometry (1996)

Real-time feedback control of semiconductor processes based on in situ sensors can complement present statistical process control techniques. In this article, we explore the potential of quadrupole mass spectrometry as an in situ sensing technique. We show that it is possible to sense the fluxes of important species in a plasma process and use these measurements to implement a multivariable control scheme. As an example, the control of hydrogen, unreacted ammonia, and direct current bias in a plasma enhanced chemical vapor deposition silicon nitride process is demonstrated.
Imaging Nanoscale Electromagnetic Near-Field Distributions Using Optical Forces (2015)

We demonstrate the application of Atomic Force Microscopy (AFM) for mapping optical near-fields with nanometer resolution, limited only by the AFM probe geometry. By detecting the optical force between a gold coated AFM probe and its image dipole on a glass substrate, we profile the electric field distributions of tightly focused laser beams with different polarizations. The experimentally recorded focal force maps agree well with theoretical predictions based on a dipole-dipole interaction model. We experimentally estimate the aspect ratio of the apex of gold coated AFM probe using only optical forces. We also show that the optical force between a sharp gold coated AFM probe and a spherical gold nanoparticle of radius 15 nm, is indicative of the electric field distribution between the two interacting particles. Photo Induced Force Microscopy (PIFM) allows for background free, thermal noise limited mechanical imaging of optical phenomenon over wide range of wavelengths from Visible to RF with detection sensitivity limited only by AFM performance.
Case 33-2010 (2010)

A 22-year-old woman was admitted because of blurred vision and acute renal failure. One week earlier, pain and blurred vision had developed in the right eye. Valacyclovir, leucovorin, prednisone, sulfadiazine, and pyrimethamine were prescribed. Dark urine, nausea, and vomiting developed.
Multilayer Perceptrons and Data Compression (2007)

This paper investigates the feasibility of using artificial networks as a tool for data compression. More precisely, the paper measures compression capabilities of the standard multilayer perceptrons. An outline of a possible neural data compression method is given. The method is based on training a perceptron to reproduce a given data file. Experiments are presented, where the outlined method has been simulated by using differently configured perceptrons and various data files. The best compression rates obtained in the experiments are listed, and compared with similar results produced in a previous paper by holographic networks.
Microanatomy and number of nerve fibres of the lower intercostal nerves with respect to a nerve anastomosis. Donor nerve analysis. I. (IV). (1992)

A human intercostal nerve has about 10,000 myelinated nerve fibres, of which about 1000 to 2000 are motor. At about the axillary line the nervus intercostalis splits into the ramus cutaneous lateralis and a deep branch to the musculus rectus abdominis and other muscles. The ramus cutaneous lateralis consists of 2 skin branches of about 3000 nerve fibres and a muscle branch to the musculus obliquus externus of about 400 to 1100 nerve fibres. The deep branch to the musculus obliquus internus, the musculus transversus and the musculus rectus abdominis and the anterior skin consists of about 2500 to 7000 fibres of which 400 to 1700 are skin fibres. There is indication that the muscle branch to the musculus obliquus externus has about 50% motor fibres. The intercostal nerve is, as it splits after about 20 cm into 4 branches, a suitable donor of at least 2 different muscle functions and a skin sensible function for a direct nerve anastomosis. A crude model for calculating matching probabilities of motor and sensory fibres between donor and acceptor nerves is introduced. Besides the importance of having enough donor nerve fibres, it is calculated that the small amount of motor nerve fibres can be best used if muscle branches of the donor nerves are connected to muscle branches of the acceptor nerves. Because of the separation between normal laboratory animals and humans on the phylogenetic scale, differences in regeneration and plasticity are discussed.
High Q RF coils on silicon integrated circuits (2003)

We report on out-of-plane micro-machined inductors exhibiting record high quality factors (Q) on silicon integrated circuits. The coils are made by three-dimensional self-assembly of stress-engineered structures fabricated with standard semiconductor batch processing techniques. Coils fabricated on low resistance CMOS-compatible silicon exhibit quality factors of over 70 at 1 GHz. BiCMOS test oscillators utilizing these micro-machined coils show significant phase noise reduction over similar oscillators using conventional spiral coils.
Trypsin‐like protease of mites: purification and characterization of trypsin‐like protease from mite faecal extract <i>Dermatophagoides farinae</i>. Relationship between trypsin‐like protease and <i>Der f</i> III (1993)

A serine protease from mite faecal extract, Dermatophagoides farinae, was purified using DEAE-Sephacel anion exchange chromatography and Superdex 75 pg gel chromatography. The molecular weight of this protease was 34 kD on SDS-PAGE under reducing conditions. The optimal pH and temperature of the protease were 8.0 and 47 degrees C, respectively. In addition, this protease cleaved arginyl or lysyl residue containing substrates selectively and was only inhibited by aprotinin, FUT-175, and soy bean trypsin inhibitor and not by chymostatin, E-64 and iodoacetic acid. These results show that our purified serine protease belongs to the trypsin-type. Purified trypsin-like protease was shown to be allergenic by enzyme-linked immunosorbent assay. Antigenicity of trypsin-like protease was completely different from those of Der f I and Der f II. Both, 20 N-terminal amino acid sequence and amino acid compositions of the purified protease were very similar to those of Der f III. Good similarities were found between trypsin-like protease and Der f III concerning physicochemical properties such as molecular weight on SDS-PAGE and ammonium sulphate solubility. Summarizing the above data, it can be concluded that a trypsin-like protease from mite faecal extract is actually the Der f III allergen and that it may be involved in the digestive process of the mite as it was found not in mite body but in mite faeces.
Rolling Resistance of Pneumatic Tires (1978)

Abstract Linear relations have been observed experimentally between tire equilibrium rolling resistance, tire load, and the reciprocal of tire inflation pressure. These variables are used to formulate a simple general expression for rolling resistance, and predictions made with this expression are compared with measured data.
Acylation of HIV proteins (1989)

Conference Article| October 01 1989 Acylation of HIV proteins T. SAERMARK; T. SAERMARK *Laboratory for Protein Chemistry, University of Copenhagen, Sigurdsgade 34, DK-2200N Denmark Search for other works by this author on: This Site PubMed Google Scholar F. BEX F. BEX †Department of Molecular Biology, University of Brussels, 67, rue des Chevaux, 1640 Rhode-Saint-Genese, Belgium Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (5): 869–871. https://doi.org/10.1042/bst0170869 Article history Received: May 11 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation T. SAERMARK, F. BEX; Acylation of HIV proteins. Biochem Soc Trans 1 October 1989; 17 (5): 869–871. doi: https://doi.org/10.1042/bst0170869 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: NMT, N-myristoyltransferase This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Molecular orbital theory of the properties of inorganic and organometallic compounds. 6. Extended basis sets for second‐row transition metals (1987)

Abstract A series of efficient split‐valence basis sets for second‐row transitions metals, termed 3‐21G, has been constructed based on previously formulated minimal expansions of Huzinaga, and in a manner analogous to the previous development of 3‐21G basis sets for first‐row metals. The Huzinaga three Gaussian expansions for s ‐ and p ‐type orbitals of given n quantum number have been fit by least squares to new three Gaussian combinations in which the two sets of functions share the same Gaussian exponents. The original three Gaussian expansions for 1 s , 3 d , and 4 d atomic orbitals have been employed as is. The valence description comprises 4 d ‐ 5 s ‐ and 5 p ‐type functions, each of which has been split into two and one Gaussian parts. 5 p functions, while not populated in the ground state of the free atom, are believed to be important in the description of the bonding in molecules. The performance of the 3‐21G basis sets is examined with regard to the calculation of equilibrium geometries and normal‐mode vibrational frequencies for a variety of simple inorganic and organometallic compounds incorporating second‐row transition metals.
ACTS: An automatic Chinese text segmentation system for full text retrieval (1995)

Text segmentation is a prerequisite for text retrieval systems. Chinese texts cannot be readily segmented into words because they do not contain word boundaries. ACTS is an automatic Chinese text segmentation proto-type for Chinese full text retrieval. It applies partial syntactic analysis—the analysis of morphemes, words, and phrases. The idea was originally largely inspired by experiments on English morpheme and phrase-analysis-based text retrieval, which are particularly germane to Chinese, because neither Chinese nor English texts have morpheme and phrase boundaries. ACTS is built on the hypothesis that Chinese words and phrases exceeding two characters can be characterized by a grammar that describes the concatenation behavior of the morphological and syntactic categories of their formatives. This is examined through three procedures: (1) Segmentation—texts are divided into one and two character segments by matching against a dictionary; (2) Category disambiguation—the syntactic categories of segments are determined according to context; (3) Parsing—the segments are analyzed based on the grammar, and subsequently combined into compound and complex words for indexing and retrieval. The experimental results, based on a small sample of 30 texts, show that most significant words and phrases in these texts can be extracted with a high degree of accuracy. © 1995 John Wiley & Sons, Inc.
DroidLogger: Reveal suspicious behavior of Android applications via instrumentation (2012)

As the mobile devices increased rapidly in recent years, mobile malware is becoming a severe threat to users. Traditional malware detection uses signature-based methods, but these methods can be evaded by obfuscation or polymorphism. So the behavior-based detection techniques were proposed recently. To capture the apps' behavior, previous works either use OS level tool such as strace to capture system call, or intercept high level API by modifying the virtual machine. However, the information retrieved from the former method is too difficult to understand the program's behavior, and the technique used in latter method requires to modify the emulator, which it is not compatible when the Android version upgrade. In this paper, we proposed a new light-weight method to understand the applications' behavior by logging program's API and corresponding arguments. We build the logging system DroidLogger, which instruments the logging code into the application binary, and prints out the API usage information at run time. We analyzed several malware and show DroidLogger can reveal the malicious behavior effectively.
Red cell rheology in stomatocyte-echinocyte transformation: roles of cell geometry and cell shape (1986)

The influence of the shape of the red blood cell during stomatocyte- echinocyte transformation on its deformability was studied by microsieving through pores with diameters of 2.6, 4.5, and 6.9 micron. A stomatocytic transformation was produced by chlorpromazine (0.02, 0.1, and 0.5 mmol/L) and an echinocytic transformation by sodium salicylate (7.5, 30, and 120 mmol/L). For spherostomatocytes, an increase in filtration resistance through 2.6 and 4.5 micron pores was observed, whereas for spheroechinocytes, a decrease in filtration resistance through 2.6 micron pores was found. Larger pores (6.9 micron) were not sensitive to those shape changes. The changes in deformability can be explained by the fact that the surface area of (sphero)-stomatocytes decreased, whereas that of (sphero)-echinocytes increased; the cell volume remained essentially constant. Echinocytes produced by 24-hour adenosine triphosphate depletion differed from drug- induced echinocytes: they had an increased cell volume at constant surface area and consequently an increased filtration resistance through 2.6- and 4.5-micron filter pores. Shape changes with spicule formation are therefore not a homogeneous entity, and cell geometric factors (eg, surface area and volume) must be assessed with care. The viscosity of red cell suspensions at a hematocrit level of 45% was higher for drug-induced echinocytes than discocytes or stomatocytes at all shear rates tested. We conclude that the normal discocyte represents an optimum shape for the flow in vivo since a stomatocytic transformation could impair the passage through the microcirculation (decrease in cell filterability) and an echinocytic transformation could impair the flow in larger vessels (increase in blood viscosity).
Silver(1+) ion catalyzed rearrangements. XXXII. Unsaturated heterocyclic systems. XCIII. Probing of the interrelation between heteroatomic substitution and equilibrium imbalance in 2,8-trimethylenesemibullvalene derivatives (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSilver(1+) ion catalyzed rearrangements. XXXII. Unsaturated heterocyclic systems. XCIII. Probing of the interrelation between heteroatomic substitution and equilibrium imbalance in 2,8-trimethylenesemibullvalene derivativesLeo A. Paquette, Ronald K. Russell, and Richard L. BursonCite this: J. Am. Chem. Soc. 1975, 97, 21, 6124–6134Publication Date (Print):October 1, 1975Publication History Published online1 May 2002Published inissue 1 October 1975https://doi.org/10.1021/ja00854a027RIGHTS & PERMISSIONSArticle Views119Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
High efficient XPW generation for high contrast high energy ultrashort laser pulses (2011)

Cross polarized wave generation (XPW) is a well established technique for contrast enhancement of ultrashort pulses in high energy laser systems [1]. Efficient conversion with XPW only occurs at high intensities. Weaker, unconverted pre and post pulses are thus rejected by the second polarizer, thereby improving the temporal contrast of the pulse. XPW has several drawbacks especially in terms of simultaneously achieving high conversion efficiencies and output energies. Limitations in seeding the nonlinear filter with high energies arise from the upper intensity limit of white light generation while high conversion efficiencies require excellent beam quality.
Networks-On-Chip Based on Dynamic Wormhole Packet Identity Mapping Management (2009)

This paper presents a network-on-chip (NoC) with flexible infrastructure based on dynamic wormhole packet identity management. The NoCs are developed based on a VHDL approach and support the design flexibility. The on-chip router uses a wormhole packet switching method with a synchronous parallel pipeline technique. Routing algorithms and dynamic wormhole local packet identity (ID-tag) mapping management are proposed to support a wire sharing methodology and an ID slot division multiplexing technique. At each communication link, flits belonging to the same message have the same local ID-tag, and the ID-tag is updated before the packet enters the next communication link by using an ID-tag mapping management unit. Therefore, flits from different messages can be interleaved, identified, and routed according to their allocated ID slots. Our NoC guarantees in order and lossless message delivery.
Regiocontrol in opening of 2H-cyclopenta[b]furanones with organocopper reagents (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegiocontrol in opening of 2H-cyclopenta[b]furanones with organocopper reagentsDennis P. Curran, Meng Hsin Chen, David Leszczweski, Richard L. Elliott, and Donna M. RakiewiczCite this: J. Org. Chem. 1986, 51, 9, 1612–1614Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/jo00359a048https://doi.org/10.1021/jo00359a048research-articleACS PublicationsRequest reuse permissionsArticle Views934Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pyrrolo[2,3-d]pyrimidine-Core-Extended π-Systems: Synthesis of 2,4,7-Triarylpyrrolo[2,3-d]pyrimidines (2011)

A simple and facile synthesis of novel fluorescent pyrrolo[2,3-d]pyrimidines with various aryl and heteroaryl assemblies in positions 2, 4, and 7 of the heterocycle by combination of the Suzuki cross-coupling and copper(I) iodide N-arylation reactions of chloropyrrolo[2,3-d]pyrimidines with arylboronic acids and haloarenes is described.
Flow Cytometric Analysis of RNA Synthesis by Detection of Bromouridine Incorporation (2000)

RNA synthesis has traditionally been investigated by a laborious and time-consuming radiographic method involving incorporation of tritiated uridine. Now a faster non-radioactive alternative has emerged, based on immunocytochemical detection. This method utilizes the brominated RNA precursor bromouridine, which is taken into a cell, phosphorylated, and incorporated into nascent RNA. The BrU-substituted RNA is detected by permeabilizing the cells and staining with certain anti-BrdU antibodies. This dynamic approach yields information complementing that provided by cellular RNA content analysis at a given time and may be of value in studies of cellular activation and gene expression.