gebhart/patrepeval huggingface dataset:
Monoclonal antibodies against plasma protease inhibitors: I. Production and characterization of 23 monoclonal antibodies against human α2 (1984)

23 hybridomas secreting monoclonal antibodies against human alpha 2-antiplasmin, the fast-acting inhibitor of plasmin present in plasma, have been produced by the cell-fusion technique. Isotyping of the monoclonal antibodies has revealed that 14 monoclonal antibodies belong to the class IgG1, 6 to the class IgG2a, and 3 to the class IgG2b. All light chains belong to the kappa group. The specificity and relative avidity of these monoclonals have been determined using an indirect enzyme-linked immunosorbent assay. 13 monoclonals exhibit a relatively high avidity for alpha 2-antiplasmin, 5 are of intermediate avidity, and 5 of low avidity. The epitope specificity of these 23 monoclonal antibodies, originating from a single mouse, have been examined in inhibition experiments. A group of 10 monoclonal antibodies exhibit a very similar inhibition pattern. Partial inhibition effects displayed by 10 other antibodies define partially overlapping antigenic regions. The binding of these antibodies seems to produce a conformational change in the alpha 2-antiplasmin molecule, reducing the binding of two other antibodies. The last antibody defines an independent epitope.
Finding the edge of salt via a dual‐velocity flood (2005)

Imaging an overturned salt edge with turning waves often requires large apertures, long recording times and a sediment velocity profile that appropriately increases with depth and that is unobstructed by other salt bodies within the aperture of interest, conditions that may not always be available in practice. In some situations, data that may not meet all of the turning‐wave‐image criteria can be used to find the salt face via a dual‐velocity‐model flood technique similar to a vertical‐seismic‐profile (VSP) proximity survey. In this case, the reflectors that truncate against salt are imaged at their truncation point in the correct position, helping to define the salt face.
Design and Synthesis of New Naphthalenic Derivatives as Ligands for 2-[125I]Iodomelatonin Binding Sites (1995)

New melatonin-like agents were designed from the frameworks of 2,5-dimethoxyphenethylamine, an important structural moiety for the 5-HT receptor, and (2-methoxynaphthyl)-ethylamine. The compounds were synthesized by classical methods and evaluated in binding assays with chicken brain membranes using 2-[125I]iodomelatonin as the radioligand. Preliminary studies on the series of N-acyl-disubstituted phenethylamines showed the favorable role of the methoxy group in the ortho position of the side chain on the affinity for the receptor (Ki = 8 +/- 0.2 nM) for N-[2-(2-methoxy-5-bromophenyl)ethyl]propionamide (3o). This effect was confirmed in a series of the naphthalene derivatives, a bioisosteric moiety of the indole ring, and several potent ligands for melatonin binding sites were prepared such as N-[2-(2-methoxynaphthyl)ethyl]propionamide (4b) (Ki = 0.67 +/- 0.05 nM) and N-[2-(2,7-dimethoxynaphthyl)ethyl]cyclopropylformamide (Ki = 0.05 +/- 0.004 nM) (4k). Structure-activity relationships are discussed with regard to melatonin and bioisosteric naphthalenic compound 2. The Ki value for 4b was affected to a similar extent to that of melatonin by GTP-gamma-S or Mn2+ in competition experiments, suggesting an agonist profile for this compound.
Vision in Insects: Pathways Possibly Underlying Neural Adaptation and Lateral Inhibition (1977)

Like horizontal cells in vertebrate retinas, horizontal amacrine cells beneath the insect eye intervene between receptors and interneurons at the first level of synapses. Synaptic arrangements between amacrines and interneurons that give rise to regular networks of axon collaterals may explain recent electrophysiological observations of lateral inhibition beneath the insect retina. Neural adaptation mechanisms acting on single retinotopic channels or assemblies of channels can also be referred to reciprocal relationships between receptors and first-order interneurons as well as to centrifugal cells from levels of so-called photopic receptor endings.
Secure Device Pairing Methods: An Overview (2017)

The procedure of setting up a secure communication channel among unfamiliar human-operated devices is called “Secure Device Pairing”. Secure binding of electronic devices is a challenging task because there are no security measures and commonly trusted infrastructure. It opens up the doors for many security threats and attacks e.g. man in middle and evil twin attacks. In order to mitigate these attacks different techniques have been proposed; some level of user participation is required in decreasing attacks in the device pairing process. A comparative and comprehensive evaluation of prominent secure device pairing methods is described here. The main motive of this research is to summarize the cryptographic protocols used in pairing process and compare the existing methods to secure the pairing devices. That will help in selecting best method according to the situation, as the most popular or easy method, instead they choose different methods in different circumstances.
A TECHNIQUE FOR LID LOADING IN THE MANAGEMENT OF THE LAGOPHTHALMOS OF FACIAL PALSY (1974)

From the Department of Surgery of the Stanford University School of Medicine, Stanford, Calif., Los Altos, Calif.
Architecture logicielle et méthodologie de conception embarquée sous contraintes temps réel pour la radio logicielle (2011)

Cette etude repond au probleme d'ordonnancement temps reel de composants logiciels s'executant sur un processeur de traitement du signal dans un contexte de radio logicielle. Elle vise ainsi a completer l'offre en termes d'outillage de conception radio logicielle. Dans la pratique actuelle, l'ordonnancement temps reel des applications de traitement du signal flexibles s'executant sur un processeur donne, est effectue de maniere manuelle, en utilisant des methodes empiriques, et en prenant des marges non negligeables. Etant donnee l'augmentation pressentie du nombre de composants logiciels de la couche physique s'executant simultanement sur un meme processeur dans les futures radios logicielles, ces methodes seront sujettes a erreur, feront perdre beaucoup de temps et ne trouveront pas necessairement de solutions d'ordonnancement valides meme lorsqu'il en existera une. Pour cela, cette these definit un nouveau modele de tâche representant plus precisement le comportement des tâches dans certains contextes de radio logicielle : le modele GMF (Generalized Multi-Frame) non cyclique. Pour ce modele, nous presentons une formulation du calcul du temps de reponse des tâches, ainsi qu'un nouveau test de faisabilite suffisant pour des tâches s'executant sur un processeur avec la politique d'ordonnancement Earliest Deadline First (EDF). Nous fournissons aussi pour ce modele de tâche un algorithme efficace, permettant la determination exacte de la faisabilite temps reel. Nous presentons dans cette these un nouveau flot de conception IDM (Ingenierie Dirigee par les Modeles), permettant de specifier les parametres rendant possibles une analyse d'ordonnancabilite temps reel des composants logiciels s'executant sur un processeur dans une radio logicielle. Cette these propose des methodes pour calculer les contraintes temporelles dans une radio logicielle. Elle presente les elements du standard MARTE a utiliser pour renseigner les contraintes dans le modele ainsi que les regles de transformations de modeles qui permettent d'obtenir un modele exploitable par un outil d'analyse d'ordonnancabilite temps reel. Cette these presente une approche, implantee sous forme d'un outil de simulation, effectuant l'analyse d'ordonnancement temps reel des tâches de traitement du signal flexibles s'executant sur un processeur suivant une politique d'ordonnancement hybride. Cet outil est integre au flot IDM propose.
Physiological characterization of Escherichia coli rpoB mutants with abnormal control of ribosome synthesis (1983)

We have previously reported the isolation of Escherichia coli rpoB mutants in which the control of ribosome synthesis by the nucleotide effector guanosine tetraphosphate (ppGpp) is altered, owing to a 20-fold increased sensitivity of the mutant RNA polymerases to ppGpp. In these mutants, the level of ppGpp during exponential growth is decreased about 10-fold, relative to that of rpoB+ wild-type strains, such that a near normal partitioning of RNA polymerase occurs with respect to stable RNA (rRNA and tRNA) gene activity. Here, the physiological effects of two different rpoB alleles in a relA+ and relA background were analyzed in greater detail by comparison with their isogenic rpoB+ wild-type parents. For a given growth medium, the rpoB mutations were found to affect four parameters which resulted in a reduction of growth rate. The results reinforce a previous conclusion that a key element in control of the bacterial growth rate is a mutual relationship between control of ribosome synthesis by ppGpp and control of relA-independent ppGpp metabolism by the concentration and function of ribosomes.
Tissue inhibitors of metalloproteinases and metalloproteinases in atherosclerosis (1998)

The ability of the metalloproteinases to degrade extracellular matrix proteins is essential for the matrix remodelling that occurs during infiltration of inflammatory cells, intimal thickening, angiogenesis and plaque rupture which are a result of atherosclerosis. Increased metalloproteinase activity therefore requires stimulation of metalloproteinase expression by cytokines and growth factors, activation of metalloproteinases, and downregulation of tissue inhibitors of metalloproteinases. In addition, metalloproteinases may influence atherosclerosis by processing of proteins involved in inflammation and cell growth and death and the tissue inhibitors of metalloproteinases may also play a less inhibitory role by influencing cell growth and apoptosis.
Photon-Efficient Computational 3-D and Reflectivity Imaging With Single-Photon Detectors (2015)

Capturing depth and reflectivity images at low light levels from active illumination of a scene has wide-ranging applications. Conventionally, even with detectors sensitive to individual photons, hundreds of photon detections are needed at each pixel to mitigate Poisson noise. We develop a robust method for estimating depth and reflectivity using fixed dwell time per pixel and on the order of one detected photon per pixel averaged over the scene. Our computational image formation method combines physically accurate single-photon counting statistics with exploitation of the spatial correlations present in real-world reflectivity and 3-D structure. Experiments conducted in the presence of strong background light demonstrate that our method is able to accurately recover scene depth and reflectivity, while traditional imaging methods based on maximum likelihood (ML) estimation or approximations thereof lead to noisier images. For depth, performance compares favorably to signal-independent noise removal algorithms such as median filtering or block-matching and 3-D filtering (BM3D) applied to the pixelwise ML estimate; for reflectivity, performance is similar to signal-dependent noise removal algorithms such as Poisson nonlocal sparse PCA and BM3D with variance-stabilizing transformation. Our framework increases photon efficiency 100-fold over traditional processing and also improves, somewhat, upon first-photon imaging under a total acquisition time constraint in raster-scanned operation. Thus, our new imager will be useful for rapid, low-power, and noise-tolerant active optical imaging, and its fixed dwell time will facilitate parallelization through use of a detector array.
Proposal for a Certified Standard for Use in Hemoglobinometry. Second and Final Report (1958)

Journal Article Proposal for a Certified Standard for Use in Hemoglobinometry. Second and Final Report Get access R. Keith Cannan, D.Sc R. Keith Cannan, D.Sc Chairman Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 30, Issue 3, 1 September 1958, Pages 211–215, https://doi.org/10.1093/ajcp/30.3.211 Published: 01 September 1958 Article history Received: 24 March 1958 Accepted: 21 April 1958 Published: 01 September 1958
Synthesis and Cross-Linking of a Benzoxazine-Containing Anthracene Moiety: Thermally Stable Photoluminescent Benzoxazine Resin (2020)

A novel benzoxazine derivative, 9,10-bis(6-ethynyl-3-phenyl-3,4-dihydro-1,3-benzoxazine)anthracene (1a), was synthesized by the Sonogashira–Hagihara coupling reaction of 9,10-dibromoanthracene and 6-ethynyl-3-phenyl-3,4-dihydro-1,3-benzoxazine. A CH2Cl2 solution of 1a luminesced with a high quantum yield (Φ = 81%). Compound 1a afforded solvent-insoluble cross-linked polybenzoxazine 1b by the bulk polymerization at 250 °C. Solution polymerization of a dilute solution of 1a at 200 °C afforded solvent-soluble samples, accompanied by a decrease of photoluminescence intensity. The weight loss values of 1a and 1b were 81 and 87%, respectively, under nitrogen at 500 °C. We believe that the present study will lead to thermally stable curing resins whose degree of curing can be estimated with the naked eye by observing the decrease of photoluminescence.
Seizure Threshold in Electroconvulsive Therapy (1987)

In a random-assignment trial to unilateral right and bilateral electrode placements, electroconvulsive therapy (ECT) stimulus intensity was titrated to just above seizure threshold for each of 52 depressed patients. Seizure threshold was quantified in units of charge. There was a 12-fold range in the minimum electrical intensity necessary to produce seizure. Sex, age, electrode placement, and the cumulative number of treatments were each associated with seizure threshold. Bilateral ECT had both a higher initial seizure threshold and a greater cumulative increase in seizure threshold compared with unilateral ECT. Clinical and research implications are discussed with respect to dosing strategies in ECT.
Incorporation of thioether building blocks into an α<sub>v</sub>β<sub>3</sub>‐specific RGD peptide: Synthesis and biological activity (2003)

We report the design, synthesis, and binding affinities of a family of thioether analogues of the alpha(v)beta(3)-specific compound c[(Mpa)RGDD(tBuG)C]-NH(2). The synthesis of the thioether building blocks is scalable and produced the desired products in good yields. The linear peptides were synthesized on solid supports, followed by cyclization in solution. Our analogues demonstrate interesting binding data to the isolated receptors. In particular, the peptide c[NH-Arg-Gly-Asp-Asp-(tBuG)-Cys(S-CH(2)-CO)]NH(2) (1) exhibits differences in binding when compared to the parent compound and demonstrates potent affinity to the alpha(v)beta(3) and alpha(5)beta(1) receptors while having reduced binding to the alpha(IIb)beta(3) receptor. This result combined with the replacement of the disulfide with a thioether makes this compound interesting for further development.
The Chemistry of Hop Constituents (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chemistry of Hop ConstituentsRoger StevensCite this: Chem. Rev. 1967, 67, 1, 19–71Publication Date (Print):February 1, 1967Publication History Published online1 May 2002Published inissue 1 February 1967https://pubs.acs.org/doi/10.1021/cr60245a002https://doi.org/10.1021/cr60245a002research-articleACS PublicationsRequest reuse permissionsArticle Views1976Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-Accuracy Molecular Mass Determination for Peptides and Proteins by Fourier Transform Mass Spectrometry (1994)

A new calibration method has been developed for Fourier transform mass spectrometry (FTMS) that is accurate to better than 0.001% (10 ppm) for peptides and proteins up to 5700 Da. The custom-designed FTMS instrument used for this work has a matrix-assisted laser desorption/ionization (MALDI) source located outside of the magnetic field in a differentially pumped chamber, and ions are injected through the fringing fields of the magnet into the FTMS analyzer cell by a long quadrupole ion guide. The mass spectrometer is calibrated with four model compounds ([Arg8]-vasopressin, melittin, bovine insulin B-chain, and bovine insulin) of known molecular mass. The set of measured ion resonance frequencies (f) for these compounds are fit to a three-term calibration equation of the form f = A(z/m) + B(V) + C(V2) (m/z), where m/z is the mass-to-charge ratio of a calibrant peak, V is the trapping voltage, and A, B, and C are calibration coefficients that depend on the magnetic field strength and the dimensions of the analyzer cell. The same set of calibration coefficients can be used for many weeks because the magnet and the electronics of the FTMS instrument are very stable. This method is useful because unknowns can be run separately without the need to add an internal calibration compound in with the sample.
Psychedelic Microdosing: A Subreddit Analysis (2019)

Self-administration of very low doses of psychedelic drugs to improve mental health and wellbeing and enhance cognitive function, known as microdosing, has received recent media attention, but little research has been conducted. We conducted a content analysis of discussions about microdosing from the online forum Reddit. We examined motivations, dosing practices, and perceived benefits and limitations of microdosing. Motivations included self-management of mental health issues, improvement of psychosocial wellbeing, and cognitive enhancement. Self-reported benefits included cognitive and creative enhancement, reduced depression and anxiety, enhanced self-insight and mindfulness, improved mood and attitude toward life, improved habits and health behaviors, and improved social interactions and interpersonal connections. Perceived limitations included issues related to dosing, adverse physical effects, taking illegal substances, limited or no mental health or cognitive improvement, increased anxiety, unpleasant "off" days, only short-term benefits, and concerns about dependence and drug-related risks. Standard doses of psychedelic drugs provided in therapeutic settings have potential as novel treatments for some mental health conditions, but clinical research is needed to understand if this is also the case for microdosing. In the meantime, harm reduction resources should be developed and made available to provide the best available information on the safer use of self-administered psychedelics.
Social Networking Site (2010)

Social networking has become one of the most popular applications on the Internet since the burst of the dot-com bubble. Apart from being a haven for teenagers and online marketers, social networking sites are increasingly adopted by the corporate community. The trend makes viable many new business models and applications. The popularity of these sites has altered the way society interacts, but it also greatly heightened the threats of cyber crime. Safety and crime issues aside, the massive amount of user-generated content in these Web 2.0-enabled social networking sites are becoming fertile grounds for viruses. Furthermore, these sites pose great challenges on how to protect copyrighted works as they are havens for digital content sharing. Society must learn to balance the benefits of social networking with its drawbacks as the phenomenon is an inescapable global trend, expanding at the speed of light.
Applying an information gathering architecture to Netfind: a white pages tool for a changing and growing Internet (1994)

The Internet is quickly becoming an indispensable means of communication and collaboration, based on applications such as electronic mail, remote information retrieval, and multimedia conferencing. A fundamental problem for such applications is supporting resource discovery in a fashion that keeps pace with the Internet's exponential growth in size and diversity. Netfind is a scalable tool that locates current electronic mail addresses and other information about Internet users. Since the time we first deployed Netfind in 1990, it has evolved considerably, making use of more types of information sources. As well as more sophisticated mechanisms to gather and cross-correlate information. In this paper, we describe these techniques, and present a general framework for gathering and harnessing widely distributed information in a diverse and growing Internet environment. At present, Netfind gathers information from 17 different types of sources, providing a particularly thorough demonstration of an information gathering architecture.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Application of Reburning for NOx Control to a Firetube Package Boiler (1985)

A 730 kW (2.5 × 106 Btu/hr) firetube package boiler was used to demonstrate the application of reburning for NOx emission control. An overall reduction of 50 percent from an uncontrolled NOx emission of 200 ppm was realized by diverting 15 percent of the total boiler load to a natural-gas-fired second stage burner. Tests indicate that the overall reaction order of destruction with respect to initial NOx is greater than one; thus, larger reductions can be expected from reburning applications to systems with higher initial NOx. Rich zone stoichiometry has been identified as the dominant process variable. Primary zone stoichiometry and rich zone residence time are parameters that can be adjusted to maximize NOx reduction. Reburning applied to firetube package boilers requires minimal facility modification. Natural gas would appear to be an ideal reburning fuel as nitrogen in the reburning fuel has been shown to inhibit NOx reduction.