gebhart/patrepeval huggingface dataset:
Intravenous gamma globulin therapy in systemic juvenile rheumatoid arthritis (1990)

Intravenous (IV) gamma globulin has been successfully used as replacement therapy for antibody-deficient patients and, more recently, in the treatment of autoimmune diseases such as idiopathic thrombocytopenic purpura, myasthenia gravis, and Kawasaki disease. In view of the successful treatment of these diseases, we initiated a pilot study of the effect of IV gamma globulin in systemic juvenile rheumatoid arthritis (JRA). Eight patients with active systemic JRA that was unresponsive to first-line agents, second-line agents, and/or corticosteroids received this therapy monthly for 6 months. Outcome measures included changes in articular and extraarticular features, steroid dosage, and laboratory parameters. Following IV gamma globulin therapy, there was significant improvement in arthritis and/or morning stiffness in 5 of 8 patients, while extraarticular features significantly improved in 7 of 8 patients. At study entry, 6 of 8 patients were receiving prednisone; at study end, prednisone was discontinued in 3 patients and decreased by more than 50% in the other 3. Overall, there was an 80% reduction in the prednisone dosage. Initially, all patients had anemia, low levels of serum albumin, and an elevated erythrocyte sedimentation rate, while a thrombocytosis was seen in 7 of 8 patients. Serum IgG was initially elevated in 6 patients. IV gamma globulin therapy resulted in a significant increase in hemoglobin and albumin levels and a significant decrease in the mean serum IgG level, platelet count, and erythrocyte sedimentation rate. In only 1 patient did IV gamma globulin fail to significantly improve the clinical or laboratory features of the disease. We suggest that this therapy may be beneficial in the treatment of systemic JRA.
Self-switching with a nonlinear birefringent loop mirror (2000)

We investigate switching characteristics of the nonlinear birefringent loop mirror which consists of a symmetric directional coupler, a birefringent fiber, and a symmetry-breaking element that converts linearly polarized light to circularly polarized light, and vice versa. The condition for total reflection in the linear regime is obtained using the Jones matrix formalism, The switching curves have been obtained through numerical computations both in the nondispersive pulse regime and in the soliton-like pulse regime. Parameter values suitable for practical applications of our device as an intensity filter are obtained.
Natural Landscape Preferences: A Predictive Model (1969)

Competition and pressure for new land uses have accelerated the need for natural resource managers to understand the interrelationships between natural features in a landscape and the public's preferences for that landscape. The purpose of this study was to identify what quantitative variables in photographs of landscapes were significantly related to public preference for those landscapes. Using factor and multiple-regression analyses, an equation was developed that used six variables and accounted for 66 percent of the variation in preference scores for photographs of landscapes. It can be concluded that it seems possible to quantify aesthetics through the methods described.
Workload scheduling in distributed stream processors using graph partitioning (2015)

With ever increasing data volumes, large compute clusters that process data in a distributed manner have become prevalent in industry. For distributed stream processing platforms (such as Storm) the question of how to distribute workload to available machines, has important implications for the overall performance of the system. We present a workload scheduling strategy that is based on a graph partitioning algorithm. The scheduler is application agnostic: it collects the communication behavior of running applications and creates the schedules by partitioning the resulting communication graph using the METIS graph partitioning software. As we build upon graph partitioning algorithms that have been shown to scale to very large graphs, our approach can cope with topologies with millions of tasks. While the experiments in this paper assume static data loads, our approach could also be used in a dynamic setting. We implemented our proposed algorithm for the Storm stream processing system and evaluated it on a commodity cluster with up to 80 machines. The evaluation was conducted on four different use cases - three using synthetic data loads and one application that processes real data. We compared our algorithm against two state-of-the-art scheduler implementations and show that our approach offers significant improvements in terms of resource utilization, enabling higher throughput at reduced network loads. We show that these improvements can be achieved while maintaining a balanced workload in terms of CPU usage and bandwidth consumption across the cluster. We also found that the performance advantage increases with message size, providing an important insight for stream-processing approaches based on micro-batching.
3-D Lung Segmentation by Incremental Constrained Nonnegative Matrix Factorization (2015)

Accurate lung segmentation from large-size 3-D chest-computed tomography images is crucial for computer-assisted cancer diagnostics. To efficiently segment a 3-D lung, we extract voxel-wise features of spatial image contexts by unsupervised learning with a proposed incremental constrained nonnegative matrix factorization (ICNMF). The method applies smoothness constraints to learn the features, which are more robust to lung tissue inhomogeneities, and thus, help to better segment internal lung pathologies than the known state-of-the-art techniques. Compared to the latter, the ICNMF depends less on the domain expert knowledge and is more easily tuned due to only a few control parameters. Also, the proposed slice-wise incremental learning with due regard for interslice signal dependencies decreases the computational complexity of the NMF-based segmentation and is scalable to very large 3-D lung images. The method is quantitatively validated on simulated realistic lung phantoms that mimic different lung pathologies (seven datasets), in vivo datasets for 17 subjects, and 55 datasets from the Lobe and Lung Analysis 2011 (LOLA11) study. For the in vivo data, the accuracy of our segmentation w.r.t. the ground truth is 0.96 by the Dice similarity coefficient, 9.0 mm by the modified Hausdorff distance, and 0.87% by the absolute lung volume difference, which is significantly better than for the NMF-based segmentation. In spite of not being designed for lungs with severe pathologies and of no agreement between radiologists on the ground truth in such cases, the ICNMF with its total accuracy of 0.965 was ranked fifth among all others in the LOLA11. After excluding the nine too pathological cases from the LOLA11 dataset, the ICNMF accuracy increased to 0.986.
Recording and playing back interactive media streams (2005)

Recording systems and media servers for networked audio and video streams have become an important part of today's Internet. In contrast to this, only a few recording and playback solutions currently exist for the data streams of interactive media applications (e.g., shared whiteboards and distributed virtual environments). So far these solutions are application-specific: individual algorithms and implementations are required for each application that is to be recorded. In this paper, we are proposing generic algorithms for the recording and playback of interactive media streams. These algorithms are based on a common model for the class of interactive media. They enable full random access to recordings by initializing the replaying applications with the required state information (e.g., the current slide in a recorded presentation). We have implemented these algorithms in the Interactive Media on Demand (IMoD) system. In order to interpret the semantics of an interactive media stream, the system requires that the Real-Time Application-Level Protocol for Distributed Interactive Media (RTP/I) protocol is used for the framing of the transmitted data. Any application using RTP/I can be recorded directly using the system without any modification. Interactive media streams not using RTP/I can be recorded using the generic recording algorithms. However, they require an adaptation of the system so that it is able to extract a minimal set of information from the application-level protocol of these streams. In addition to the generic recording algorithms, we present the architecture and major design considerations of the system and discuss the experiences gained from recording different interactive media applications.
Efficacy and Safety of Luteinizing Hormone-Releasing Hormone Antagonist Cetrorelix in the Treatment of Symptomatic Benign Prostatic Hyperplasia<sup>1</sup> (1998)

As the life expectancy for men increases, more cases of benign prostatic hyperplasia (BPH) will be expected. Symptomatic BPH causes morbidity and can lower the quality of life. We investigated whether short term administration of the LH-releasing hormone antagonist cetrorelix could provide an improved treatment for men with BPH. Thirteen patients with moderate to severe symptomatic BPH were treated with cetrorelix (5 mg, s.c., twice daily for 2 days followed by 1 mg/day, s.c., for 2 months). Patients were evaluated at baseline, during treatment, and up to 18 months after therapy. We determined the effects of cetrorelix on the International Prostate Symptom Score (IPSS), Quality of Life score, sexual function, prostate size, uroflowmetry, and hormonal levels. Treatment with cetrorelix produced a decline of 52.9% (P < 0.0001) in IPSS, a 46% improvement in the Quality of Life score (P < 0.001), a rapid reduction of 27% (P < 0.006) in prostatic volume, and an increase in peak urinary flow rates by 2.86 mL/s. Serum testosterone fell to castrate levels on day 2, but was inhibited only by 64-74% during maintenance therapy, and after cessation of treatment returned to normal. During long term follow-up, most patients continued to show a progressive improvement in urinary symptoms (decline in IPSS from 67% to 72% at weeks 20 and 85, respectively) and an enhancement of sexual function, and prostatic volume remained normal. Our study demonstrates that in patients with symptomatic BPH, treatment with cetrorelix is safe and produces long term improvement.
A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells (2008)

TAZ (WWTR1), identified as a 14-3-3 binding protein with a PDZ binding motif, modulates mesenchymal stem cell differentiation. We now show that TAZ plays a critical role in the migration, invasion, and tumorigenesis of breast cancer cells. TAZ is conspicuously expressed in human breast cancer cell lines in which its expression levels generally correlate with the invasiveness of cancer cells. Overexpression of TAZ in low-expressing MCF10A cells causes morphologic changes characteristic of cell transformation and promotes cell migration and invasion. Conversely, RNA interference-mediated knockdown of TAZ expression in MCF7 and Hs578T cells reduces cell migration and invasion. TAZ knockdown in MCF7 cells also retards anchorage-independent growth in soft agar and tumorigenesis in nude mice. Significantly, TAZ is overexpressed in approximately 20% of breast cancer samples. These results indicate that TAZ plays a role in the migration, invasion, and tumorigenesis of breast cancer cells and thus presents a novel target for the detection and treatment of breast cancer.
3‐D prestack depth migration by Kirchhoff operator splitting (1996)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 19963‐D prestack depth migration by Kirchhoff operator splittingAuthors: V. DevauxG. H. F. GardnerT. RampersadV. DevauxHouston Advanced Research Center (HARC), G. H. F. GardnerHouston Advanced Research Center (HARC), and T. RampersadHouston Advanced Research Center (HARC)https://doi.org/10.1190/1.1826673 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1826673FiguresReferencesRelatedDetailsCited By4. Approximations of Full Prestack Migration21 March 20123. Approximations of Full Prestack Migration21 March 2012Velocity model estimation for depth imaging: Comparison of three tomography methods on a 2D real data setGeophysical Prospecting, Vol. 52, No. 5Imaging the Subsurface with 2-D and 3-D Seismic Data7. 3-D Seismic Exploration21 March 2012 SEG Technical Program Expanded Abstracts 1996ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1996 Pages: 2106 publication data© 1996 Copyright © 1996 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION V. Devaux, G. H. F. Gardner, and T. Rampersad, (1996), "3‐D prestack depth migration by Kirchhoff operator splitting," SEG Technical Program Expanded Abstracts : 455-458. https://doi.org/10.1190/1.1826673 Plain-Language Summary PDF DownloadLoading ...
Accuracy Assessment of Digital Elevation Models Using GPS (2008)

Accuracy Assessment of Digital Elevation Models Using GPS A Digital Elevation Model (DEM) is a digital representation of ground surface topography or terrain with different accuracies for different application fields. DEM have been applied to a wide range of civil engineering and military planning tasks. DEM is obtained using a number of techniques such as photogrammetry, digitizing, laser scanning, radar interferometry, classical survey and GPS techniques. This paper presents an assessment study of DEM using GPS (Stop&Go) and kinematic techniques comparing with classical survey. The results show that a DEM generated from (Stop&Go) GPS technique has the highest accuracy with a RMS error of 9.70 cm. The RMS error of DEM derived by kinematic GPS is 12.00 cm.
Sterol composition of the Adriatic sea algae Ulva lactuca, Codium dichotomum, Cystoseira adriatica and Fucus virsoides (2005)

The sterol composition of two green algae and two brown algae from the South Adriatic was determined. In the green alga Ulva lactuca, the principal sterols were cholesterol and isofucosterol. In the brown alga Cystoseira adriatica, the main sterols were cholesterol and stigmast-5-en-3?-ol, while the characteristic sterol of the brown algae, fucosterol, was found only in low concentration. The sterol fractions of the green alga Codium dichotomum and the brown alga Fucus virsoides contained practically only one sterol each, comprising more than 90 % of the total sterols (clerosterol in the former and fucosterol in the latter).
Model compression as constrained optimization, with application to neural nets. Part II: quantization (2017)

We consider the problem of deep neural net compression by quantization: given a large, reference net, we want to quantize its real-valued weights using a codebook with $K$ entries so that the training loss of the quantized net is minimal. The codebook can be optimally learned jointly with the net, or fixed, as for binarization or ternarization approaches. Previous work has quantized the weights of the reference net, or incorporated rounding operations in the backpropagation algorithm, but this has no guarantee of converging to a loss-optimal, quantized net. We describe a new approach based on the recently proposed framework of model compression as constrained optimization \citep{Carreir17a}. This results in a simple iterative "learning-compression" algorithm, which alternates a step that learns a net of continuous weights with a step that quantizes (or binarizes/ternarizes) the weights, and is guaranteed to converge to local optimum of the loss for quantized nets. We develop algorithms for an adaptive codebook or a (partially) fixed codebook. The latter includes binarization, ternarization, powers-of-two and other important particular cases. We show experimentally that we can achieve much higher compression rates than previous quantization work (even using just 1 bit per weight) with negligible loss degradation.
Knowledge-oriented programming (1993)

This paper presents knowledge-oriented programming, a framework for giving high-level knowledgebased descriptions of distributed protocols. We extend the notion of knowledge-based programs of [FHMV93] by allowing high-level actions that are defined in terms of changing the state of knowledge of processes in the system. As a result, both the choice of which actions to perform and the actions themselves are defined explicitly in terms of the processes' knowledge. We concentrate on a class of high-level notify actions that can be used to abstract away details of communication. Examples are considered, including solutions to the atomic commitment problem and to the sequence transmission problem. 1
Examination of Effects of H<sub>2</sub> Concentration in Reactant Gas on GaN Growth by Gallium Hydride Vapor Phase Epitaxy (2006)

The dependence of H2 concentration in a reactant gas on the rate of GaN single crystal growth by gallium hydride vapor phase epitaxy (GaH-VPE) method was investigated. In the GaH-VPE, gallium hydride (GaHx), which was synthesized by introducing H2 gas into Ga melt, reacts with NH3 to form GaN single crystals. Growth rate increased with a H2 concentration less than 20 mol % and reached a maximum at H2 concentration of 20 mol %. However, too much H2 gas decreased the growth rate. The observation of the surface morphology of grown films by scanning electron microscopy (SEM) clarified that H2 gas, which did not contribute to the reaction with Ga for GaHx formation, promoted the decomposition of GaN at a high H2 concentration. This study gave us the knowledge that the growth rate of GaN crystals greatly depends on the reaction efficiency between Ga and H2. In addition, GaN film with a smooth surface was grown at a high NH3/GaHx ratio.
Notes on the Red Heifer (1908)

Research Article| December 01 1908 Notes on the Red Heifer Henry Preserved Smith Henry Preserved Smith Search for other works by this author on: This Site Google Journal of Biblical Literature (1908) 27 (2): 153–156. https://doi.org/10.2307/3259979 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Henry Preserved Smith; Notes on the Red Heifer. Journal of Biblical Literature 1 December 1908; 27 (2): 153–156. doi: https://doi.org/10.2307/3259979 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveSBL PressJournal of Biblical Literature Search Advanced Search The text of this article is only available as a PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
Mid‐term results of Autologous Matrix‐Induced Chondrogenesis for treatment of focal cartilage defects in the knee (2010)

Articular cartilage defects heal poorly. Autologous Matrix-Induced Chondrogenesis (AMIC) is an innovative treatment for localized full-thickness cartilage defects combining the well-known microfracturing with collagen scaffold and fibrin glue. The purpose of this prospective study was to evaluate the medium-term results of this enhanced microfracture technique for the treatment of chondral lesions of the knee. Thirty-two chondral lesions in 27 patients were treated with AMIC. Within the context of clinical follow-up, these patients were evaluated for up to 5 years after the intervention. Five different scores (Meyer score, Tegner score, Lysholm score, ICRS score, Cincinnati score) as well as radiographs were used for outcome analysis. Articular resurfacing was assessed by magnetic resonance imaging (MRI). The average age of patients (11 females, 16 males; mean body mass index 26, range 20-32) was 37 years (range 16-50 years). The mean defect size of the chondral lesions was 4.2 cm(2) (range 1.3-8.8 cm(2)). All defects were classified as grade IV according to the Outerbridge classification. The follow-up period was between 24 and 62 months with a mean of 37 months. Twenty out of 23 individuals (87%) questioned were subjectively highly satisfied with the results after surgery. Significant improvement (P < 0.05) of all scores was observed as early as 12 months after AMIC, and further increased values were notable up to 24 months postoperatively. MRI analysis showed moderate to complete filling with a normal to incidentally hyperintense signal in most cases. Results did not show a clinical impact of patient's age at the time of operation, body mass index and number of previous operations (n.s.). In contrast, males showed significant higher values in the ICRS score compared to their female counterparts. AMIC is an effective and safe method of treating symptomatic full-thickness chondral defects of the knee in appropriately selected cases. However, further studies with long-term follow-up are needed to determine whether the grafted area will maintain structural and functional integrity over time.
The synthesis and study of the photoinitiated cationic polymerization of novel cycloaliphatic epoxides (1995)

Abstract The synthesis of a series of difunctional epoxides bearing two epoxycyclohexyl groups linked together by an alkylene ether group has been carried out. Subsequently, the reactivities of these novel monomers was investigated and compared to the reactivity of the cycloali‐phatic epoxide, 3,4‐epoxycyclohexylmethyl 3′,4′‐epoxycyclohexane carboxylate ( I ) in pho‐toinitiated cationic polymerization. It was observed that alkylene oxide linking the two epoxycyclohexyl groups was short and the monomers are more reactive than I . The effects of the photoinitiator structure and the experimental conditions of the cationic photopo‐lymerization on the rates was also studied using real‐time infrared spectroscopy. © 1995 John Wiley & Sons, Inc.
Central and peripheral consequences of the chronic blockade of CB<sub>1</sub>cannabinoid receptor with rimonabant or taranabant (2009)

The endocannabinoid system plays a crucial role in the pathophysiology of obesity. However, the clinical use of cannabinoid antagonists has been recently stopped because of its central side-effects. The aim of this study was to compare the effects of a chronic treatment with the CB(1) cannabinoid antagonist rimonabant or the CB(1) inverse agonist taranabant in diet-induced obese female rats to clarify the biological consequences of CB(1) blockade at central and peripheral levels. As expected, chronic treatment with rimonabant and taranabant reduced body weight and fat content. Interestingly, a decrease in the number of CB(1) receptors and its functional activity was observed in all the brain areas investigated after chronic taranabant treatment in both lean and obese rats. In contrast, chronic treatment with rimonabant did not modify the density of CB(1) cannabinoid receptor binding, and decreased its functional activity to a lower degree than taranabant. Six weeks after rimonabant and taranabant withdrawal, CB(1) receptor density and activity recovered to basal levels. These results reveal differential adaptive changes in CB(1) cannabinoid receptors after chronic treatment with rimonabant and taranabant that could be related to the central side-effects reported with the use of these cannabinoid antagonists.