gebhart/patrepeval huggingface dataset:
Infliximab Pharmacokinetics in Inflammatory Bowel Disease Patients (2008)

Infliximab, a chimeric monoclonal antibody, has profoundly modified the treatment of several inflammatory diseases, but no satisfactory description of its pharmacokinetics is available. The objective of this study is to describe the pharmacokinetics of infliximab and to explore the sources of its interindividual variability. Thirty-three chronic inflammatory bowel disease patients were studied. Infliximab serum concentrations, obtained during therapeutic drug monitoring, were analyzed using a population approach. Influence of sex, weight, age, concomitant immunosuppressive treatment, and development of antibodies toward infliximab (ATI) on pharmacokinetic parameters was investigated. A two-compartment model with first-order distribution and elimination constants allowed a satisfactory description of infliximab serum concentrations. Mean population distribution and elimination half-lives were 4.3 and 18.5 days, respectively. Weight and sex were found to significantly influence volume of distribution of the central compartment, which increased with weight and was higher in men. Clearance was 2.7 times higher, and elimination half-life was 34% lower in the presence of ATI. In two patients, an increase in infliximab dose or a decrease in dosing interval lead to a decrease in infliximab clearance toward its value in patients without ATI. Infliximab pharmacokinetics are similar to those of other monoclonal antibodies, notably with an elimination half-life of approximately 3 weeks. Both body weight and sex were found to influence infliximab pharmacokinetics, and its clearance increased thrice in the presence of ATI.
Deep-level impurities in CdTe/CdS thin-film solar cells (2000)

We have studied deep-level impurities in CdTe/CdS thin-film solar cells by capacitance–voltage (C–V), deep-level transient spectroscopy (DLTS), and optical DLTS (ODLTS). CdTe devices were grown by close-spaced sublimation. Using DLTS, a dominant electron trap and two hole traps were observed. These traps are designated as E1 at EC−0.28 eV, H1 at EV+0.34 eV, and H2 at EV+0.45 eV. The presence of the E1 and H1 trap levels was confirmed by ODLTS. The H1 trap level is due to Cu-induced substitutional defects. The E1 trap level is believed to be a deep donor and is attributed to the doubly ionized interstitial Cu or a Cu complex. The E1 trap is an effective recombination center and is a lifetime killer.
A Latent Semantic Analysis-Based Approach to Geographic Feature Categorization from Text (2011)

Geographic feature categorization from text addresses the need for querying and finding geographic features from text documents. Although many text classification techniques have been developed, there are limitations to apply to geographic features due to the uniqueness of the geography features. In this paper we propose a method to classify geographic features based on latent semantic analysis and domain knowledge. The empirical experiment indicates that the proposed method achieves satisfactory categorizing effectiveness.
The isolation of a toxic substance from agenized wheat flour (1951)

Research Article| January 01 1951 The isolation of a toxic substance from agenized wheat flour P. N. Campbell; P. N. Campbell 1National Institute for Medical Research Search for other works by this author on: This Site PubMed Google Scholar T. S. Work; T. S. Work 1National Institute for Medical Research Search for other works by this author on: This Site PubMed Google Scholar E. Mellanby E. Mellanby 2Nutrition Building, Mill Hill, London, N. W. 7 Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1951) 48 (1): 106–113. https://doi.org/10.1042/bj0480106 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation P. N. Campbell, T. S. Work, E. Mellanby; The isolation of a toxic substance from agenized wheat flour. Biochem J 1 January 1951; 48 (1): 106–113. doi: https://doi.org/10.1042/bj0480106 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1951 CAMBRIDGE UNIVERSITY PRESS1951 Article PDF first page preview Close Modal You do not currently have access to this content.
THE BEHAVIOR OF SUSPENDED SOLID PARTICLES AND LIQUID IN BUBBLE COLUMNS (1972)

The longitudinal concentration distribution of solid particles and liquid mixing in 6.6, 12.2 and 21.4 cm i. d. bubble columns were measured and were analyzed by using diffusion model. The longitudinal dispersion coefficient of solid particles and liquid based on actual mean slurry velocity, the mean settling velocity of solid particles, and the concentration of solid particles at the top of the column, respectively, were correlated with dimensionless groups. From these correlations empirical equations were obtained. The values of concentration of solid particles calculated from the empirical equations agreed with the observed values within ±20%.
METASTABLE AMORPHOUS FERROMAGNETIC PHASES IN PALLADIUM-BASE ALLOYS (1965)

the distribution function. The atomic arrangement in the amorphous alloys is very similar to that found in liquid tellurium which is itseif closely related to the crystal structure of solid tellurium. (auth)
Halofuginone Induces Matrix Metalloproteinases in Rat Hepatic Stellate Cells via Activation of p38 and NFκB (2006)

The semisynthetic plant alkaloid halofuginone (HAL) was reported to prevent and partly reverse experimental liver fibrosis. However, its mechanisms of action are poorly understood. We therefore aimed to determine the antifibrotic potential of HAL and to characterize involved signal transduction pathways in hepatic stellate cells (HSCs). Results were compared with its in vivo effects in a rat model of reversal of established liver fibrosis induced by thioacetamide. In vitro HAL inhibited HSC proliferation and migration dose dependently at submicromolar concentrations. HAL (200 nm) up-regulated matrix metalloproteinase (MMP)-3 and MMP-13 expression between 10- and 50-fold, resulting in a 2- to 3-fold increase of interstitial collagenase activity. Procollagen alpha1(I) and MMP-2 transcript levels were suppressed 2- to 3-fold, whereas expression of other profibrogenic mRNAs remained unaffected. p38 mitogen-activated protein kinase (p38 MAPK) and nuclear factor kappaB(NFkappaB) pathways were activated by HAL, and specific inhibitors of p38 MAPK and NFkappaB dose dependently inhibited MMP-13 induction. Treatment with HAL did not affect HSC viability, and observed effects were reversible after its removal. In vivo HAL up-regulated MMP-3 and -13 mRNA expression 1.5- and 2-fold, respectively, in cirrhotic rats, whereas tissue inhibitor of metalloproteinase-1 was suppressed by 50%. In conclusion, submicromolar concentrations of HAL inhibit HSC proliferation and migration and up-regulate their expression of fibrolytic MMP-3 and -13 via activation of p38 MAPK and NFkappaB. The remarkable induction of MMP-3 and -13 makes HAL a promising agent for antifibrotic combination therapies.
Evaluation and use of an anti‐cynomolgus monkey CD79b surrogate antibody–drug conjugate to enable clinical development of polatuzumab vedotin (2019)

The suitability of the surrogate ADC for evaluation of CD79b-dependent pharmacology was demonstrated, and anti-tumour activity, pharmacokinetics/pharmacodynamics, and toxicity data with both ADCs supported the entry of polatuzumab vedotin into clinical trials.
KinMap: a web-based tool for interactive navigation through human kinome data (2017)

KinMap represents a new generation of kinome tree viewers which facilitates interactive exploration of the human kinome. KinMap enables generation of high-quality annotated images of the human kinome tree as well as exchange of kinome-related data in scientific communications. Furthermore, KinMap supports multiple input and output formats and recognizes alternative kinase names and links them to a unified naming scheme, which makes it a useful tool across different disciplines and applications. A web-service of KinMap is freely available at http://www.kinhub.org/kinmap/ .
Arum Palaestinum with isovanillin, linolenic acid and β-sitosterol inhibits prostate cancer spheroids and reduces the growth rate of prostate tumors in mice (2015)

Fortified Arum palaestinum Boiss caused a reduction in live cells within prostate cancer spheroids and blocked tumor growth in xenografted prostate tumors in mice without signs of toxicity.
Laser Radar Receiver Using A Digicon Detector (1989)

The features of the Digicon detector concept are described and related to the requirements for a direct-imaging laser radar receiver. Recent experimental results on sensitivity and time resolution of a prototype detector are reported. The status of an integrated receiver experiment based on a prototype Digicon detector is reported. Laboratory experiments on the magnification of the electron image to improve the spatial resolution of advanced Digicon detectors are also described.
Evidence for Multiple Shared Antigenic Determinants within Ro60 and Other Lupus-Related Ribonucleoprotein Autoantigens in Human Autoimmune Responses (2005)

Ab responses directed against several ribonucleoprotein (RNP) Ags are a characteristic feature of systemic lupus erythematosus (SLE). Previous work in our laboratory using mouse model systems had revealed that both epitope spreading and inherent cross-reactivity between ribonucleoproteins contributes to the observed multiple specificities in autoimmune sera. We have now extended these studies to human autoimmune responses. Using purified polyclonal and mAbs derived from SLE patients, cross-reactivity between Ro60 and SmD was demonstrated. The cross-reactive epitope was mapped to nonhomologous regions on Ro60(481-505) and SmD(88-102). Five mAbs specifically recognized apoptotic cells, demonstrated variable levels of cross-reactivity toward other nonhomologous ribonucleoprotein targets and bound multiple, nonoverlapping and nonhomologous epitopes on Ro60. Our study demonstrates that cross-reactivity between frequently targeted autoantigens is an important aspect of human systemic autoimmune responses. The presence of multiple cross-reactive epitopes on Ro60 might be important for the generation of anti-Ro60 Ab in SLE patients and in normal individuals displaying no evidence of clinical disease.
Reinforcement of a Porous PMMA Filter Material by Nanodispersed Clay (2001)

No abstracts.
switchBox: an R package for k–Top Scoring Pairs classifier development (2014)

Supplementary data are available at Bioinformatics online.
From a Train Window (1973)

Journal Article From a Train Window Get access Prudence Murray Prudence Murray Search for other works by this author on: Oxford Academic Google Scholar English: Journal of the English Association, Volume 22, Issue 114, Autumn 1973, Pages 111-a–111, https://doi.org/10.1093/english/22.114.111-a Published: 01 October 1973
TiO2 Photocatalysis for Indoor Air Applications: Effects of Humidity and Trace Contaminant Levels on the Oxidation Rates of Formaldehyde, Toluene, and 1,3-Butadiene (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTiO2 Photocatalysis for Indoor Air Applications: Effects of Humidity and Trace Contaminant Levels on the Oxidation Rates of Formaldehyde, Toluene, and 1,3-ButadieneTimothy N. Obee and Robert T. BrownCite this: Environ. Sci. Technol. 1995, 29, 5, 1223–1231Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/es00005a013https://doi.org/10.1021/es00005a013research-articleACS PublicationsRequest reuse permissionsArticle Views4004Altmetric-Citations517LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vortex Breakdown (1972)

The field of fluid mechanics is rapidly advancing, driven by unprecedented volumes of data from experiments, field measurements, and large-scale simulations at multiple spatiotemporal scales. Machine learning (ML) offers a wealth of techniques to extract ...Read More
Effect of amorphization and carbon co-doping on activation and diffusion of boron in silicon (2006)

We investigate the impact of amorphization and C co-implantation on B diffusion and activation properties after conventional spike rapid thermal annealing (RTA). We observe that after complete recrystallization at 600°C the B tail deepens by 5nm (at 5×1018at.∕cm3) due to B diffusion in a-Si. After spike RTA it becomes 12nm deeper with respect to an as-implanted profile, which proves that both diffusion mechanisms in a-Si and c-Si are important. However, the B diffusion in c-Si is sensitive to the fraction of substitutional C incorporated into c-Si. The best junction depth is Xj=16.5nm, with abruptness of 2nm/decade and Rs=583Ω∕◻.
Nested turbo codes for the Costa problem (2008)

Driven by applications in data-hiding, MIMO broadcast channel coding, precoding for interference cancellation, and transmitter cooperation in wireless networks, Costa coding has lately become a very active research area. In this paper, we first offer code design guidelines in terms of source- channel coding for algebraic binning. We then address practical code design based on nested lattice codes and propose nested turbo codes using turbo-like trellis-coded quantization (TCQ) for source coding and turbo trellis-coded modulation (TTCM) for channel coding. Compared to TCQ, turbo-like TCQ offers structural similarity between the source and channel coding components, leading to more efficient nesting with TTCM and better source coding performance. Due to the difference in effective dimensionality between turbo-like TCQ and TTCM, there is a performance tradeoff between these two components when they are nested together, meaning that the performance of turbo-like TCQ worsens as the TTCM code becomes stronger and vice versa. Optimization of this performance tradeoff leads to our code design that outperforms existing TCQ/TCM and TCQ/TTCM constructions and exhibits a gap of 0.94, 1.42 and 2.65 dB to the Costa capacity at 2.0, 1.0, and 0.5 bits/sample, respectively.
Un texto clave en la obra de Luis Rafael Sánchez: la importancia de llamarse Daniel Santos (1993)

The practice of nursing in the psychosocial care centers in mental health is something made in the institutions daily from established interactions among professionals, patients, and the patient's family. This research is somewhat exploratory and has a qualitative approach. It aims to know the daily practice of professionals from Psychosocial Care Centers on daily practice of the nurse in this kind of work. The collected data were made by means of-semi-structured interviews. From the thematic analysis of the data, two themes appeared: the nurse establishes the first contact with the patients; that is, the nurse is the link between doctors and patients. The results show that the practice of nursing in mental health searches to construct inventive actions, establish affective ties, welcome the patients, and contradict the different way by which some uncommon people are seen the "insane" as a threat. It is a practice that emphasizes the meaning of life production, that is, the increase of the patient's capacity to establish social exchanges, giving him/her greater autonomy.
A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 Is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A (2004)

An alpha-helical MA-3 domain appears in several translation initiation factors, including human eukaryotic translation initiation factor 4G (eIF4G) and DAP-5/NAT1/p97, as well as in the tumor suppressor Pdcd4. The function of the MA-3 domain is, however, unknown. C-terminal eIF4G (eIG4Gc) contains an MA-3 domain that is located within the eIF4A-binding region, suggesting a role for eIF4A binding. Interestingly, C-terminal DAP-5/NAT1/p97 contains an MA-3 domain, but it does not bind to eIF4A. Mutation of amino acid residues conserved between Pdcd4 and eIF4Gc but not in DAP-5/NAT1/p97 to the amino acid residues found in the DAP-5/NAT1/p97 indicates that some of these amino acid residues within the MA-3 domain are critical for eIF4A-binding activity. Six Pdcd4 mutants (Pdcd4(E249K), Pdcd4(D253A), Pdcd4(D414K), Pdcd4(D418A), Pdcd4(E249K,D414K), and Pdcd4(D253A,D418A)) lost >90% eIF4A-binding activity. Mutation of the corresponding amino acid residues in the eIF4Gc also produced similar results, as seen for Pdcd4. These results demonstrate that the MA-3 domain is important for eIF4A binding and explain the ability of Pdcd4 or eIF4Gc but not DAP-5/NAT1/p97 to bind to eIF4A. Competition experiments indicate that Pdcd4 prevents ca. 60 to 70% of eIF4A binding to eIF4Gc at a Pdcd4/eIF4A ratio of 1:1, but mutants Pdcd4(D253A) and Pdcd4(D253A,D418A) do not. Translation of stem-loop structured mRNA is susceptible to inhibition by wild-type Pdcd4 but not by Pdcd4(D253A), Pdcd4(D418A), or Pdcd4(D235A,D418A). Together, these results indicate that not only binding to eIF4A but also prevention of eIF4A binding to the MA-3 domain of eIF4Gc contributes to the mechanism by which Pdcd4 inhibits translation.
How to erase surface plasmon fringes (2006)

The authors report on the imaging of surface plasmon polaritons (SPPs) by leakage radiation microscopy in both direct and Fourier space. They show that manipulating the intensity distribution in the Fourier plane allows them to selectively image SPP beams propagating along specific directions. Thereby individual SPP beams are made accessible for direct quantitative analysis which is important in cases where the interaction between different SPP beams leads to interference fringes obscuring the individual components.
A comprehensive evaluation of capture-recapture models for estimating software defect content (2000)

An important requirement to control the inspection of software artifacts is to be able to decide, based on more objective information, whether the inspection can stop or whether it should continue to achieve a suitable level of artifact quality. A prediction of the number of remaining defects in an inspected artifact can be used for decision making. Several studies in software engineering have considered capture-recapture models to make a prediction. However, few studies compare the actual number of remaining defects to the one predicted by a capture-recapture model on real software engineering artifacts. The authors focus on traditional inspections and estimate, based on actual inspections data, the degree of accuracy of relevant state-of-the-art capture-recapture models for which statistical estimators exist. In order to assess their robustness, we look at the impact of the number of inspectors and the number of actual defects on the estimators' accuracy based on actual inspection data. Our results show that models are strongly affected by the number of inspectors, and therefore one must consider this factor before using capture-recapture models. When the number of inspectors is too small, no model is sufficiently accurate and underestimation may be substantial. In addition, some models perform better than others in a large number of conditions and plausible reasons are discussed. Based on our analyses, we recommend using a model taking into account that defects have different probabilities of being detected and the corresponding Jackknife Estimator. Furthermore, we calibrate the prediction models based on their relative error, as previously computed on other inspections. We identified theoretical limitations to this approach which were then confirmed by the data.
Balanced phase matching in segmented KTiOPO4 waveguides (1990)

A new phase matching technique is described which is based on phase mismatch balancing in crystal or waveguide segments that are short compared to their respective coherence lengths. The technique is demonstrated experimentally in a mixed bulk crystal/waveguide structure in KTiOPO4, resulting in a second-harmonic generation conversion efficiency of 15%/W/cm2 at 1.064 μm, close to the theoretical maximum. We show that this technique can significantly broaden processing latitude for fabricating practical nonlinear optical waveguide devices.
Phosphate solubilizing microbes: sustainable approach for managing phosphorus deficiency in agricultural soils (2013)

Phosphorus is the second important key element after nitrogen as a mineral nutrient in terms of quantitative plant requirement. Although abundant in soils, in both organic and inorganic forms, its availability is restricted as it occurs mostly in insoluble forms. The P content in average soil is about 0.05% (w/w) but only 0.1% of the total P is available to plant because of poor solubility and its fixation in soil (Illmer and Schinner, Soil Biol Biochem 27:257-263, 1995). An adequate supply of phosphorus during early phases of plant development is important for laying down the primordia of plant reproductive parts. It plays significant role in increasing root ramification and strength thereby imparting vitality and disease resistance capacity to plant. It also helps in seed formation and in early maturation of crops like cereals and legumes. Poor availability or deficiency of phosphorus (P) markedly reduces plant size and growth. Phosphorus accounts about 0.2 - 0.8% of the plant dry weight. To satisfy crop nutritional requirements, P is usually added to soil as chemical P fertilizer, however synthesis of chemical P fertilizer is highly energy intensive processes, and has long term impacts on the environment in terms of eutrophication, soil fertilility depletion, carbon footprint. Moreover, plants can use only a small amount of this P since 75-90% of added P is precipitated by metal-cation complexes, and rapidly becomes fixed in soils. Such environmental concerns have led to the search for sustainable way of P nutrition of crops. In this regards phosphate-solubilizing microorganisms (PSM) have been seen as best eco-friendly means for P nutrition of crop. Although, several bacterial (pseudomonads and bacilli) and fungal strains (Aspergilli and Penicillium) have been identified as PSM their performance under in situ conditions is not reliable and therefore needs to be improved by using either genetically modified strains or co-inoculation techniques. This review focuses on the diversity of PSM, mechanism of P solubilization, role of various phosphatases, impact of various factors on P solubilization, the present and future scenario of their use and potential for application of this knowledge in managing a sustainable environmental system.