gebhart/patrepeval huggingface dataset:
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys. (1992)

Rab proteins are membrane-bound prenylated GTP-binding proteins required for the targeted movement of membrane vesicles from one organelle to another. In the current paper we have characterized and purified an enzyme that attaches geranylgeranyl residues to Rab proteins that bear the COOH-terminal sequence Cys-X-Cys (such as Rab3A) and Cys-Cys (such as Rab1A). This enzyme is designated Rab geranylgeranyl transferase (Rab GG transferase). At high salt concentrations, Rab GG transferase from rat brain cytosol separates into two components, designated A and B, both of which are required for activity. We purified Component B to apparent homogeneity and found that it contains two peptides of 60 and 38 kDa. The purified Rab GG transferase did not attach geranylgeranyl to p21H-ras-CVLL, which is prenylated by a GG transferase of the CAAX type that resembles the CAAX farnesyltransferase. Rab GG transferase was strongly inhibited by Zn2+, a cation that is absolutely required by farnesyltransferase. The Rab GG transferase was also inhibited by NaCl concentrations in excess of 100 mM. Together with previous data, the current findings indicate that mammalian cells possess at least three protein prenyltransferases (CAAX farnesyltransferase, CAAX GG transferase, and Rab GG transferase) that are specific for different classes of low molecular weight GTP-binding proteins and other proteins.
To William O. Brown (1969)

For those of us who have been members of the African Studies Association since its founding in 1958, it is hard to believe that Bill Brown will no longer be with us at our annual meetings and as an ever willing member of our committees. We became so accustomed to calling on Bill for advice and guidance at moments of crisis that we are just a bit at a loss when we realize we can no longer turn to him in need. Bill was a founding member of the ASA, a member of its board, and its past President. These offices, to which Bill was overwhelmingly elected, were no more than fitting tributes to his qualities as a scholar and a leader in his field of study -- qualities which the members of the Association recognized and to which they gladly paid tribute. But Bill was much more than a founding father; he was one of the small group who saw in the early fifties that African studies were to grow from the concern of a handful of devoted men to a major branch of area studies in the American academic roster. Bill was a member of the small committee which met from time to time in 1956 and 1957 to lay out the goals and purposes of the future association. Bill's wise counsel then, as it has so often since, prevented us from making irretrievable errors. I can remember sitting in several long and confused planning meetings in the Spring of 1958 in which alternative forms of the Association were brought up, one after another, and at the end, the group turned to Bill, who, seemingly, had absorbed all the confusing threads of the discussion. He was able to weave them together into a series of decisions which sounded much more intelligent than they ever were, I am sure, during our discussion; and out of them came the Association as it now is.
부부관계증진 프로그램이 부부 의사소통과 결혼만족도에 미치는 효과 (2000)

The purpose of this study is to find out the effects of the marriage enrichment program on marital communication and satisfaction. The program consists of three main parts: Self-understanding, Spouse-understanding, and Communication. The subjects were ten couples who volunteered to participate in the marriage enrichment program and they were mainly selected from the population who were functioning relatively well enough to enhance their relationship in Miryang, Kyungsang Namdo. The subjects were divided into 2 groups : an experimental group of 5 couples and a controlled group of 5 couples on the waiting-list. The experimental group consisted of couples who were given a relationship enhancement program of 9 treatment sessions for 9 weeks. Each session was held for 2 hours on weekends. On the other hand, the subjects in the controlled group did not receive any treatment. The instruments used to identify the treatment effects were the Marital Satisfection Scale adapted. The materials were collected twice before investigating the two groups and after doing that. The materials which resulted from this experiment were delt in ANOVA statistical method using SAS program. The conclusions were obtained after discussing and comparing the previous studies. They are as follows. 1. The Marriage Enrichment Program(MEP) shows a significant effect on marital communication. 2. MEP is effective in developing marital communication in the lower range of marital communication. 3. MEP is effective in developing mutual understanding in the lower range of marital communication. 4. MEP is effective in marital satisfaction.
Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells. (1993)

Recent investigations suggest that tumor necrosis factor (TNF)-alpha may utilize the sphingomyelin pathway for signal transduction. Signaling in this system involves hydrolysis of sphingomyelin to ceramide by action of a neutral sphingomyelinase and stimulation of a ceramide-activated protein kinase (Dressler, K. A., Mathias, S., and Kolesnick, R. N. (1992) Science 255, 1715-1718). To clarify the role of this pathway in TNF action, the present studies assessed the effect of the sphingomyelin pathway on activation of nuclear factor kappa B (NF-kappa B), an event considered integral to the transfer of the TNF message to the cell nucleus. As shown previously, TNF (1 nM) induced a marked increase in nuclear NF-kappa B binding in human leukemia (HL-60) cells within 5 min, and elevated binding was detected for as long as 1 h. Addition of a maximally effective concentration of sphingomyelinase, 0.1 units.ml-1, induced a 50% reduction in sphingomyelin content by 5 min from a basal level of 560 pmol.10(6) cells-1 and a quantitative increase in ceramide levels from 89 pmol.10(6) cells-1. Sphingomyelinase 0.1 units.ml-1 also induced an increase in nuclear NF-kappa B binding within 5 min, an effect measurable for as long as 1 h. As little as 1 x 10(-5) units.ml-1 sphingomyelinase was effective and a maximal effect occurred with 1 x 10(-3) units.ml-1. A cell-permeable ceramide analog, C8-ceramide, which mimics biologic effects of TNF-alpha, also enhanced nuclear NF-kappa B activation within minutes. In contrast, addition of a phospholipase C or a synthetic diacylglycerol (DG) analog, 1,2-dioctanoylglycerol, failed to enhance nuclear NF-kappa B binding despite large increases in cellular DG content. Further, TNF-alpha induced elevation in ceramide content by 2 min to 185% of control but did not affect DG levels. These studies provide evidence that stimulation of the sphingomyelin pathway leads to NF-kappa B activation in HL-60 cells.
The Efficacy of Low Dose Metoprolol CR/ZOK in Mild Hypertension and in Elderly Patients with Mild to Moderate Hypertension (1990)

In two separate but similarly designed placebo-controlled studies, the efficacy of metoprolol CR/ZOK 50 mg once daily was evaluated in 64 patients (mean age 53 years) with mild hypertension (Study I) and in 34 elderly patients (mean age 68 years) with mild to moderate hypertension (Study II). Both studies were of randomized, double-blind, parallel-group design, the entry criteria for diastolic blood pressure being greater than or equal to 90 less than 105 mm Hg in Study I and greater than or equal to 95 less than 110 mm Hg in Study II. Study I: The impact of metoprolol CR/ZOK 50 mg once daily for 4 weeks compared with placebo 24 hours post dosing was to produce a significant reduction in supine (P = .0001), and standing (P less than .0001) systolic blood pressures and the standing diastolic pressure (P = .035). The supine diastolic pressure was lower after metoprolol CR/ZOK but not significantly so. Study II: Metoprolol CR/ZOK 50 mg daily given to elderly hypertensives when compared with placebo 24 hours post dosing produced a significant fall in supine (P = .022) and standing (P = .022) diastolic pressure. Systolic pressure and heart rate were not significantly reduced. One patient in Study II had a nonfatal myocardial infarct whilst receiving placebo. There were no other serious adverse effects in either study and no patients were withdrawn from the trial because of drug related unwanted events. The studies indicate that 50 mg metoprolol CR/ZOK may be an effective antihypertensive agent which may prove useful in the treatment of mild to moderate hypertension, particularly in the elderly.
An Improved Frequency-Domain Interference Cancellation with DFE for CDMA (2008)

The bit error (BER) performance of CDMA in a frequency-selective fading channel can be significantly improved by the use of frequency-domain equalization (FDE). There are three methods can be used to implement FDE in CDMA uplink [I. Martoyo et al., 2003]: the cyclic prefix [K.L. Baum et al., 2002], the zero padding and the overlap-cut (OC). However, the first two methods not only yield lower bandwidth efficiency, but also create higher latency, so the OC is the better choice. In this case, we don't have to modify the structure of the frame. This is very important and useful for applications in which the frame structure is predefined. Thus, this paper proposes an approach to use the improved overlap-cut (IOC) method and parallel interference cancellation (PIC) architecture integrate with frequency domain decision feedback equalization (FD-DFE).
A Calibration Method for Extrinsic Parameters Based on Four Points (2010)

In order to solve the calibration of camera extrinsic parameters problem in texture mapping,this paper presents a geometric calibration method based on four point pairs.The first one select three points in the world coordinate system and calculate their coordinates in the camera coordinate system(world point, light heart, and image point are colinear). Transform the coordinates to a reference coordinate system and the euclidean distance is invariant. According to the homothetic triangle theory, solve the rotation matrix and translation vectoer respectively. Finally get the complete extrinsic parameters. The results from experiment show that the method is correct and feasible. This method needs only four point pairs to solve the camera extrinsic parameters, further more it has high precision and few constraints. Applied in the texture mapping, this method can establish a mapping between 3D model and digital photo, thereby it can achieve the high-precision texture mapping.
Net-Centric Adapter for Legacy Systems (2008)

Net-centric adapter for legacy systems (NCALS) is a software technology that makes legacy system data and services available in near real-time to the global information grid (GIG). The intent of NCALS is to lower the cost and risk, and to decrease the time required for legacy systems to comply with DoD net-centric technical standards. Many different systems could use a common, configurable NCALS software component to comply with these standards. The benefit to the warfighter is improved interoperability with joint and coalition forces. NCALS enables legacy systems to move to a Service- Oriented Architecture (SOA) compatible with the GIG without requiring a costly and risky re-architecture of their legacy software. In addition, NCALS enables mission critical systems such as weapon systems to segregate their real-time, mission critical software from enterprise integration software. This maintains the safety and security required by such systems, while accommodating rapid changes in Internet-based, enterprise technologies. This paper will discuss the legacy system challenge and describe a technology prototype developed by the naval surface warfare center (NSWC) Dahlgren to realize the NCALS concept. The prototype works automatically, behind the scenes, to expose legacy data to the GIG and to make GIG data available to legacy systems.
Frequency of B cells expressing germ-line gamma 1 transcripts upon IL-4 induction. (1993)

Murine B cells when activated with LPS and IL-4 have been shown to secrete IgG1 and IgE with corresponding H chain gene rearrangements. Using this system it has been previously demonstrated that transcription of gamma 1 and epsilon C region genes in their germ-line configuration occurs before switch recombination. Here, for the first time, the frequencies of B cells expressing germ-line gamma 1 transcripts are analyzed using in situ hybridization methodology. The results indicate that the combination of LPS and IL-4 induces a relatively low frequency of cells (5-12%) to express germ-line gamma 1 transcripts. Germ-line gamma 1 transcript-expressing cells were first detected on day 1 of culture with LPS and IL-4 and reached a maximum by days 3 to 5. The B cells that expressed germ-line gamma 1 transcripts appeared to be activated based on size and morphology. The frequency of B cells expressing germ-line gamma 1 transcripts approximated the frequency of C gamma 1+ plasma cells that appeared later in the cultures. These data may suggest a correlation between germ-line Ig transcript expression and the frequency of B cell precursors committed to the expression of a particular isotype.
Profound obesity associated with a balanced translocation that disrupts the SIM1 gene (2000)

Studies of mice and humans have revealed a number of genes that when mutated result in severe obesity. We have studied a unique girl with early-onset obesity and a de novo balanced translocation between chromosomes 1p22.1 and 6q16.2. Her weight gain is most likely due to excessive food intake, since measured energy expenditure was normal. We cloned and sequenced both translocation breakpoints. The translocation does not appear to affect any transcription unit on 1p, but it disrupts the SIM1 gene on 6q. SIM1 encodes a human homolog of Drosophila Sim (Single-minded), a transcription factor involved in midline neurogenesis, and is a prototypical member of the bHLH-PAS (basic helix-loop-helix + period, aryl hydrocarbon receptor, Single-minded) gene family. Our subject's trans- location separates the 5' promoter region and bHLH domain from the 3' PAS and putative transcriptional regulation domains. The transcriptional targets of SIM1 are not known. Mouse Sim1 is expressed in the developing kidney and central nervous system, and is essential for formation of the supraoptic and paraventricular (PVN) nuclei of the hypothalamus. Previous neuroanatomical and pharmacological studies have implicated the PVN in the regulation of body weight: PVN neurons express the melanocortin 4 receptor and appear to be physiological targets of alpha-melanocyte-stimulating hormone, which inhibits food intake. We hypothesize that haploinsufficiency of SIM1, possibly acting upstream or downstream of the melanocortin 4 receptor in the PVN, is responsible for severe obesity in our subject.
Estrogen Metabolites and the Risk of Breast Cancer in Older Women (2003)

The study results do not support the hypothesis that the ratio of 2-OHE1 to 16alpha-OHE1 predicts breast cancer risk.
A Fixed-Priority Scheduling Algorithm for Multiprocessor Real-Time Systems (2010)

A new algorithm was presented for semi-partitioned fixed-priority scheduling of sporadic task systems on identical multiprocessors. We designed the algorithm so that a task is qualified to migrate across processors, only if it cannot be assigned to any individual processors, in such a manner that it is never migrated back to the same processor within the same period, once it is migrated from one processor to another processor. The scheduling policy was then simplified to reduce the number of preemptions and migrations as much as possible for practical use. We also optimized the algorithm to improve schedulability. Any implicit-deadline systems are successfully scheduled by the optimized algorithm, if system utilization does not exceed 50%. We are not aware of any fixed-priority algorithms that have utilization bounds greater than 50%. Thus, our outcome seems sufficient. The simulation results showed that the new algorithm significantly outperforms the traditional fixed-priority algorithms regardless of the number of processors and the utilization of tasks. The parameters used in simulations are limited, but we can easily estimate that the new algorithm is also effective to different environments. In the future work, we will consider arbitrary-deadline systems where relative deadlines may be longer than periods, while we consider constrained-deadline systems where relative deadlines are shorter than or equal to periods. We are also interested in applying the presented semi-partitioned scheduling approach to dynamic-priority scheduling. The implementation problems of the algorithm in practical operating systems are left open.
Listening Preferences in Regard to Speech in Four Children with Developmental Disabilities (1992)

In a previous experimental study of children's listening responses in regard to speech sounds, autistic children showed preferential patterns which were in sharp contrast to a group of mentally-handicapped and normally-developing children. The present study reports the data obtained for four children whose clinical diagnosis (1) became available only some time after the study was carried out, and/or (2) differed from previously recorded clinical impressions. The results obtained support previous findings according to which a lack of attraction to speech sounds appears to be a feature of young autistic children's overall disregard to people. The present technique is discussed as a viable method to examine experimentally young autistic children's social unresponsiveness.
Adrenocortical suppression by topically applied corticosteroids in healthy dogs (1987)

Three corticosteroid products (triamcinolone acetonide, fluocinonide, betamethasone valerate) and a control product composed of water, petrolatum, mineral oil, cetyl alcohol, steryl alcohol, sodium lauryl sulfate, cholesterol, and methylparaben each were applied topically to healthy dogs (5 dogs/product) once daily for 5 consecutive days. Plasma concentrations of immunoreactive adrenocorticotropic hormone (iACTH) and cortisol were determined before 1 microgram of ACTH/kg of body weight was given intravenously (pre-ACTH values) and cortisol was again measured 60 minutes after ACTH was given (post-ACTH values). Cortisol and iACTH concentrations were determined in each dog before, during, and after administration of the corticosteroid products. All 3 corticosteroids caused prompt and sustained pituitary-adrenocortical suppression. Compared with control applications, the application of corticosteroids resulted in significant reduction of plasma cortisol and iACTH concentrations by day 2 of treatment, and the lower concentrations continued to day 5. One week after the last application of the corticosteroids, plasma iACTH concentrations in the corticosteroid-treated dogs had returned to the range of values for the control dogs; however, pre- and post-ACTH cortisol concentrations remained suppressed in all corticosteroid-treated dogs. Two weeks after the last treatment, the pre-ACTH plasma cortisol concentrations of corticosteroid-treated dogs returned to those of the control dogs, but the post-ACTH plasma cortisol concentrations remained suppressed. By 3 weeks after the last treatment, post-ACTH plasma cortisol concentrations of dogs treated with triamcinolone acetonide had returned to the range of values for the control dogs, but remained suppressed in the other 2 groups of dogs. All indices of pituitary-adrenocortical activity were within the control range by 4 weeks after the last treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
α<sub>1</sub>‐acid glycoprotein and serum binding of drugs in healthy and diseased dogs (1987)

Inter-individual variation in drug serum protein binding was studied in healthy dogs and in dogs with inflammatory diseases for lidocaine, oxprenolol and propranolol, which bind mainly to alpha 1-acid glycoprotein (alpha 1-AGP), and for diazepam, digitoxin and phenytoin, which bind mainly to albumin. For the drugs mostly bound to alpha 1-AGP, in both groups of dogs binding varied considerably, and it was markedly higher in dogs with inflammatory disease. For the other drugs, the variation in binding was smaller and did not differ between the two groups of dogs. In both groups of dogs, the alpha 1-AGP concentration varied widely; it was higher in the serum of the dogs with inflammation, while the concentration of albumin was lower in these animals. There was a significant negative correlation between percentage free lidocaine, oxprenolol or propranolol and alpha 1-AGP concentration, suggesting that the inter-individual variation in binding of these drugs is due to the variation in alpha 1-AGP concentration. There was a marked intra-individual variation in lidocaine binding and in serum alpha 1-AGP concentration, studied over a period of 3 weeks in healthy dogs; a significant negative correlation between percentage free lidocaine and alpha 1-AGP concentration was obtained.
Effects of the salience of pitch and periodicity information on the intelligibility of four-channel vocoded speech: Implications for cochlear implants (2000)

Recent simulations of continuous interleaved sampling (CIS) cochlear implant speech processors have used acoustic stimulation that provides only weak cues to pitch, periodicity, and aperiodicity, although these are regarded as important perceptual factors of speech. Four-channel vocoders simulating CIS processors have been constructed, in which the salience of speech-derived periodicity and pitch information was manipulated. The highest salience of pitch and periodicity was provided by an explicit encoding, using a pulse carrier following fundamental frequency for voiced speech, and a noise carrier during voiceless speech. Other processors included noise-excited vocoders with envelope cutoff frequencies of 32 and 400 Hz. The use of a pulse carrier following fundamental frequency gave substantially higher performance in identification of frequency glides than did vocoders using envelope-modulated noise carriers. The perception of consonant voicing information was improved by processors that preserved periodicity, and connected discourse tracking rates were slightly faster with noise carriers modulated by envelopes with a cutoff frequency of 400 Hz compared to 32 Hz. However, consonant and vowel identification, sentence intelligibility, and connected discourse tracking rates were generally similar through all of the processors. For these speech tasks, pitch and periodicity beyond the weak information available from 400 Hz envelope-modulated noise did not contribute substantially to performance.