gebhart/patrepeval huggingface dataset:
Terpenes and Phenolic Compounds from Agastache rugosa and Their Inhibitory Effect on the Release of β-Hexosaminidase in RBL-2H3 Cells (2013)

Agastache rugosa (Fisch. et Meyer) O. Kuntze., commonly known as Korean mint, is a perennial herb in the family Labiatae which is distributed in Korea, China, Japan and Russia. The herb has been used for the treatment of summer flu, summer cold, headache, stomachache, nausea, vomiting, and dyspepsia in Chinese and Korean traditional medicines. Previous studies on A. rugosa, have investigated several biological activities including antioxidative, antibacterial, antiviral, antifungal, and anticancer activities. In continuation of our search for anti-allergic compound from natural products, we have found that the hexane extract of A. rugosa has anti-allergic activity. The dried aerial part of A. rugosa was extracted with hexane. The anti-allergic activity of the hexane extract was comparatively higher than that of second-generation H1-antihistamine ketotifen as positive control. Twelve terpenes and phenolic compounds were isolated from the hexane extract. The structures of isolated compounds were identified as linalool, trans-isopulegone, linalyl acetate, β-caryophyllene, eugenol, estragole, cis-jasmone, phytol, l-menthone, methyl eugenol, and trans-carveol by comparison of their spectral data with literature values. The anti-allergic activity of isolated compounds was evaluated in an in vitro assay on β-hexosaminidase release inhibition using RBL-2H3 cells stimulated by DNP-BSA.
FROM MIRACLES TO MEDICINE (2009)

Nothing in the evolution of human thought appears more inevitable than the idea of supernatural intervention in producing and curing disease. The causes of disease are so intricate that they are reached only after ages of scientific labour. In those periods when man sees everywhere miracle and nowhere law,—when he attributes all things which he can not Understand to a will like his own,—he naturally ascribes his diseases either to the wrath of a good being or to the malice of an evil being.
Model Based Multiscale Detection and Reconstruction of 3D Vessels (1998)

The segmentation of 3D brain vessels is an important issue for physicians in order to operate an aneurysm. We introduce new vessel models for selecting a subset of interesting points near the vessel center. We also present a new approach to segment and reconstruct 3D brain vessels. The response at one scale is obtained by integrating along a circle the first derivative of the intensity in the radial direction. We also use a vessel model to choose a good parameter for a gamma-normalizatio- n of the response obtained at each scale. Once the parameter gamma is fixed, we find the relation between a vessel radius and the scale at which it is detected. From the multiscale response, we create a smoothed skeleton of the vessels and we reconstruct the vessels from their centerlines and their radii. The method has been tested on a large variety of 3D images of cerebral vessels, with excellent results. Vessels of various size and contrast are detected with remarkable robustness, even when they are close or tangent to another vessel, and most junctions are preserved. Results are obtained in a few minutes on a Dec-Alpha workstation, for a 128^3 image. This work was done in collaboration with General Electric Medical Systems Europe (GEMSE).
iNKT-Cell Responses to Glycolipids (2005)

Invariant natural killer T (iNKT) cells are an unusual group of T lymphocytes that recognize glycolipid antigens presented by the major histocompatibility complex class I-related protein CD1d. Because iNKT cells play a regulatory role in the immune system, they are attractive targets for immunotherapy. The marine-sponge-derived glycolipid alpha-galactosylceramide (alpha-GalCer) potently activates iNKT cells. In vivo administration of alpha-GalCer to mice or humans results in rapid and robust cytokine secretion by iNKT cells, followed by the activation of a variety of cell types of the innate and adaptive immune systems. These potent immunomodulatory activities of alpha-GalCer are being exploited for therapeutic purposes. Preclinical studies in mice have demonstrated that alpha-GalCer and related glycolipids can protect mice against a variety of diseases, including cancer, infections, and several autoimmune and inflammatory conditions. Although alpha-GalCer treatment of mice is associated with unwanted side-effects, it has been proven safe in clinical trials with cancer patients. These studies have raised significant enthusiasm for the development of effective and safe iNKT-cell-based immunotherapies for a variety of human diseases.
First-principles prediction of redox potentials in transition-metal compounds with<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi>LDA</mml:mi><mml:mo>+</mml:mo><mml:mi>U</mml:mi></mml:mrow></mml:math> (2004)

First-principles calculations within the local density approximation (LDA) or generalized gradient approximation (GGA), though very successful, are known to underestimate redox potentials, such as those at which lithium intercalates in transition metal compounds. We argue that this inaccuracy is related to the lack of cancellation of electron self-interaction errors in LDA/GGA and can be improved by using the $\mathrm{DFT}+U$ method with a self-consistent evaluation of the $U$ parameter. We show that, using this approach, the experimental lithium intercalation voltages of a number of transition metal compounds, including the olivine ${\mathrm{Li}}_{x}{\mathrm{MPO}}_{4}$ ($\mathrm{M}=\mathrm{Mn}$, Fe Co, Ni), layered ${\mathrm{Li}}_{x}{\mathrm{MO}}_{2}$ ($x=\mathrm{Co}$, Ni) and spinel-like ${\mathrm{Li}}_{x}{\mathrm{M}}_{2}{\mathrm{O}}_{4}$ ($\mathrm{M}=\mathrm{Mn}$, Co), can be reproduced accurately.
1 Hyperspectral Image Compression Using Three-Dimensional Wavelet Coding: A Lossy-to-Lossless Solution † (2004)

We propose an embedded, block-based, image wavelet transform coding algorithm of low complexity. The embedded coding of Set Partitioned Embedded bloCK (SPECK) algorithm is modified and extended to three dimensions. The resultant algorithm, three-Dimensional Set Partitioned Embedded bloCK (3D-SPECK), efficiently encodes 3D volumetric image data by exploiting the dependencies in all dimensions. 3D-SPECK generates embedded bit stream and therefore provides progressive transmission. We describe the use of this coding algorithm in two implementations, including integer wavelet transform as well as floating point wavelet transform, where the former one enables lossy and lossless decompression from the same bit stream, and the latter one achieves better performance in lossy compression. Wavelet packet structure and coefficient scaling are used to make the integer filter transform approximately unitary. The structure of hyperspectral images reveals spectral responses that would seem ideal candidate for compression by 3D-SPECK. We demonstrate that 3D-SPECK, a wavelet domain compression algorithm, can preserve spectral profiles well. Compared with the lossless version of the benchmark JPEG2000 (multi-component), the 3D-SPECK lossless algorithm produces average of 3.0 % decrease in compressed file size for Airborne Visible Infrared Imaging Spectrometer images, the typical hyperspectral imagery. We also conduct comparisons of the lossy implementation with other the state-of-the-art algorithms such as three-Dimensional Set Partitioning In Hierarchical Trees (3D-SPIHT)
Structure of Human Angiotensinogen Gene (1989)

A cDNA clone encoding human angiotensinogen was isolated from a cDNA library prepared from human liver mRNA and used to isolate the angiotensinogen gene. The complete exon sequence of this gene together with extensive intron and flanking sequences are reported. The human angiotensinogen gene contains five exons interrupted by four intervening sequences. We compared the intron-exon structure of this human gene with that of the rat gene or the genes coding for proteins such as alpha 1-antitrypsin and antithrombin III, whose primary amino acid sequences show similarities. The human angiotensinogen gene shows identical organization with the alpha 1-antitrypsin gene, but is different from the antithrombin III gene. The 5'-flanking sequence (-500 to -1 bp) of the human angiotensinogen gene was examined for hormone regulatory elements (HRE), which may be implicated in the interaction with the hormone receptor complexes.
<title>NIHmagic: 3D visualization, registration, and segmentation tool</title> (2000)

Interactive visualization of multi-dimensional biological images has revolutionized diagnostic and therapy planning. Extracting complementary anatomical and functional information from different imaging modalities provides a synergistic analysis capability for quantitative and qualitative evaluation of the objects under examination. We have been developing NIHmagic, a visualization tool for research and clinical use, on the SGI OnyxII Infinite Reality platform. Images are reconstructed into a 3D volume by volume rendering, a display technique that employs 3D texture mapping to provide a translucent appearance to the object. A stack of slices is rendered into a volume by an opacity mapping function, where the opacity is determined by the intensity of the voxel and its distance from the viewer. NIHmagic incorporates 3D visualization of time-sequenced images, manual registration of 2D slices, segmentation of anatomical structures, and color-coded re-mapping of intensities. Visualization of MIR, PET, CT, Ultrasound, and 3D reconstructed electron microscopy images has been accomplished using NIHmagic.
Isolation of a somatic cell hybrid retaining the der(16)t(12;16)(q13;p11.2) from a myxoid liposarcoma cell line (1993)

We developed cell line LIS-3/SV40 from a primary myxoid liposarcoma with the t(12;16)(q13;p11.2) and trisomy 8. Following fusion of LIS-3/SV40 to mouse A9 cells, we obtained hybrid LIS-3/SV40/A9-B4 which contained the der(16) but neither the der(12) nor some of the normal human chromosomes, including 12 and 16. Furthermore, microclone library ML12q1315 was constructed from microdissected fragments of chromosome bands 12q13-15 and its microclones were found to span the breakpoint in LIS-3/SV40.
Quantification of Plasma Epstein–Barr Virus DNA in Patients with Advanced Nasopharyngeal Carcinoma (2004)

Quantification of plasma EBV DNA is useful for monitoring patients with nasopharyngeal carcinoma and predicting the outcome of treatment.
Allergic bronchopulmonary aspergillosis: New concepts of pathogenesis and treatment (2001)

Allergic bronchopulmonary aspergillosis (ABPA) is a condition that results from a hypersensitivity reaction to the fungus Aspergillus fumigatus. The purpose of the present review is to examine the pathogenesis of this condition and the evidence for treatments available. Allergic bronchopulmonary aspergillosis is characterized by an intense airway inflammation with eosinophils and the formation of mucus plugs. Clinically, there are periods of exacerbation and remission that may lead to proximal bronchiectasis and fibrotic lung disease. New evidence confirms the role of intense airway inflammation with eosinophils, but also suggests a role for interleukin (IL)-8/neutrophil-mediated inflammation in this process, and the potential deficiency of anti-inflammatory cytokines such as reduced IL-10. Treatment for ABPA has so far focused on corticosteroids to suppress eosinophilic airway inflammation. An expanding knowledge of the pathology of ABPA also suggests other therapies may be of potential benefit, particularly the use of azole antifungal agents. Allergic bronchopulmonary aspergillosis is itself an important complication of asthma and cystic fibrosis. A greater understanding of the condition is required to improve management and well-designed clinical trials need to be carried out to critically assess new and current treatments. In addition, the information gained from the studies of its pathogenesis has the potential to benefit our understanding of the disease processes in asthma and bronchiectasis.
High-efficiency Ku-band HBT amplifier with 1 W CW output power (1991)

A compact, high-voltage AlGaAs/GaAs HBT was developed for applications in the Ku band using carbon-doped base structures. A single unit-cell device, operating under common-emitter mode and 10 V collector bias, produced 1.0 W CW output power at 15 GHz with 5.0 dB gain and 42% power-added efficiency. The power density of the device was a record 5.6 W/mm of emitter length.
Trustworthiness evaluation system in E-Commerce context (2016)

Today, E-Commerce has become the largest revenue generation industry, letting seller sell everything from a pen to plane to the customers across the globe. Over an E-commerce platform where user and vendor merely interact with each other, the trust is undeniably the most important factor for users to perform transactions online. But at the same time it can't be assessed directly using some pre-defined metrics. It has to be perceived from various indicators. Trustworthiness is a measure of any system as a whole provides users, service providers and communities, an assurance and advice to select a particular ecommerce platform that helps in minimizing a risk of fraud. In this paper, we are soliciting a feedback evaluation system that will act as a decision support system, which can assist users to measure the trustworthiness and usefulness of the user opinion about a product or a service by evaluating the trust degree.
Strategies for implementing a distributed platform for persistent shared objects (1991)

The development of platforms able of handling transparently distribution, heterogeneity and multilanguage software in the framework of an object model has been perceived as a promising direction This paper presents an object oriented platform which provides transparent access to remote and persistent objects defined within the Esprit project Comandos. We start by describing our object and computational model together with the basic architecture. The structure of objects and references which tries to provide acceptable efficiency is explained. This paper main focus is the description of the basic operations provided by the platform: object invocation, dynamic linking and garbage collection. Some performance measurements try to highlight the points which deserved particular attention on our implementation. A special effort was dedicated to support transparent sharing of objects. We provide a general mechanism which allows the programmer to define the policy she wants to enforce. For effi...
A full colour LCD addressed by poly Si TFTS fabricated at low temperature below 450 degrees C (2003)

A process below 450 degrees C has been developed for poly-Si thin-film transistor (TFTs). The devices have higher mobility ( approximately 50 cm/sup 2//V-s) and higher reliability than a-Si TFTs. A 3.5-in. full-colour liquid-crystal display addressed by these poly-Si TFTs is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
SYNTHESIS OF DNA AND MITOSIS IN RABBIT UTERI AFTER OESTROGEN AND PROGESTERONE INJECTIONS, AND DURING EARLY PREGNANCY (1972)

In oestrogen-primed mice, progesterone stimulates stromal mitosis and inhibits epithelial mitosis (Finn & Martin, 1967; Martin & Finn, 1968). In rabbits, however, endometrial proliferation is stimulated by progesterone. This report describes DNA synthesis (measured by [3H]thymidine incorporation) and mitosis in the uterine epithelium of ovariectomized rabbits treated with oestrogen and progesterone, and in intact animals during early pregnancy. Mature New Zealand White rabbits were given 5·0 mg colchicine (1·0 mg/kg body weight) in 1·0 ml water intraperitoneally 6 hr before death. The `mitotic index' refers to the percentage of mitoses accumulated during this 6 hr period. One hour before death, the rabbits were anaesthetized with sodium pentobarbitone and 100μCi [3H]methylthymidine (s.a. 20 Ci/mmol, from
DNA replication origins, ORC/DNA interaction, and assembly of pre-replication complex in eukaryotes (2010)

Chromosomal DNA replication in eukaryotic cells is highly complicated and sophisticatedly regulated. Owing to its large size, a typical eukaryotic genome contains hundreds to tens of thousands of initiation sites called DNA replication origins where DNA synthesis takes place. Multiple initiation sites remove the constraint of a genome size because only a certain amount of DNA can be replicated from a single origin in a limited time. The activation of these multiple origins must be coordinated so that each segment of chromosomal DNA is precisely duplicated only once per cell cycle. Although DNA replication is a vital process for cell growth and its mechanism is highly conserved, recent studies also reveal significant diversity in origin structure, assembly of pre-replication complex (pre-RC) and regulation of replication initiation along evolutionary lines. The DNA replication origins in the fission yeast Schizosaccharomyces pombe are found to contain a second essential element that is bound by Sap1 protein besides the essential origin recognition complex-binding site. Sap1 is recently demonstrated to be a novel replication initiation protein that plays an essential role in loading the initiation protein Cdc18 to origins and thus directly participates in pre-RC formation. In this review, we summarize the recent advance in understanding how DNA replication origins are organized, how pre-RC is assembled and how DNA replication is initiated and regulated in yeast and metazoans.
Top-spraying soybean meal-based diets with phytase improves protein and mineral digestibilities but not lysine utilization in rainbow trout, Oncorhynchus mykiss (Walbaum) (2004)

Two digestibility trials and two growth trials were carried out to evaluate the influence of top-sprayed phytase on apparent digestibility coefficients (ADCs) of protein and mineral and utilization in rainbow trout fed with soybean meal-based diets. In Trial 1, a semi-purified diet containing 50% soybean meal was supplemented with graded levels of phytase (0, 500, 1000, 2000 and 4000 U kg−1 diet), and fed to triplicate groups of fish. In Trial 2, commercial-type extruded feeds containing 36% soybean meal with either 0 or 2000 U phytase kg−1 were fed to five replicate groups of fish. Phytase clearly decreased phytic acid content of feces from 35 to 5 mg and from 34 to 14 mg phytic acid per g faecal dry matter in Trials 1 and 2 respectively. Apparent digestibility coefficient of P improved from 23% to 83% in Trial 1 and from 35% to 54% in Trial 2 by phytase. Apparent protein increased by 1.2% and 3.2%-units by phytase in Trials 1 and 2. Zinc digestibility was significantly increased in Trial 1, but not in Trial 2. Trials 3 and 4 were conducted to evaluate the influence of phytase on dietary P (Trial 3) and lysine (Trial 4) utilization. Three diets were prepared for each trial: P (Trial 3)- or lysine (Trial 4)-deficient basal diets, basal diets with phytase supplementation (2000 U kg−1) and P (Trial 3)- or lysine (Trial 4)-fortified diets. Rainbow trout (initial weight 20 g) were fed for 10 weeks using four and six replicates for Trials 3 and 4 respectively. Phytase increased P utilization in Trial 3 as demonstrated by an increase in vertebra ash from 24.1% to 45.4%, and by an increase in weight gain from 243% to 459% of the initial weight. Phytase did not increase lysine utilization, since neither protein retention nor weight gain were enhanced by phytase. Supplemental lysine increased protein retention and weight gain to 43.1% and 514%, respectively, and also decreased whole-body lipid contents significantly from 120 to 123 g kg−1 in fish fed the basal diet and phytase-supplemented diet to 106 g kg−1 in fish fed with lysine-fortified diet.
TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway (2006)

Transferrin receptor 2 (TfR2) possesses a YQRV motif similar to the YTRF motif of transferrin receptor 1 (TfR1) responsible for the internalization and secretion through the endosomal pathway. Raft biochemical dissection showed that TfR2 is a component of the low-density Triton-insoluble (LDTI) plasma membrane domain, able to co-immunoprecipitate with caveolin-1 and CD81, two structural raft proteins. In addition, subcellular fractionation experiments showed that TfR1, which spontaneously undergoes endocytosis and recycling, largely distributed to intracellular organelles, whereas TfR2 was mainly associated with the plasma membrane. Given the TfR2 localization in lipid rafts, we tested its capability to activate cell signalling. Interaction with an anti-TfR2 antibody or with human or bovine holotransferrin showed that it activated ERK1/ERK2 and p38 MAP kinases. Integrity of lipid rafts was required for MAPK activation. Co-localization of TfR2 with CD81, a raft tetraspanin exported through exosomes, prompted us to investigate exosomes released by HepG2 and K562 cells into culture medium. TfR2, CD81 and to a lesser extent caveolin-1, were found to be part of the exosomal budding vesicles. In conclusion, the present study indicates that TfR2 localizes in LDTI microdomains, where it promotes cell signalling, and is exported out of the cells through the exosome pathway, where it acts as an intercellular messenger.
Quantification and morphologic demonstration of reactive oxygen species produced by Walker 256 tumor cells in vitro and during metastasis in vivo. (1994)

These data provide morphologic evidence that cancer cells can produce reactive oxygen species in vivo and suggest that free radicals might contribute to endothelial damage during the metastatic process.
Nondestructive Multilevel Interconnect Parameter Characterization For High-performance Manufacturable VLSI Technologies (1993)

One of the challenges in VLSI fabrication is to design submicron multilevel metals with high yield. This paper describes a concurrent engineering methodology that provides semiconductor engineers and VLSI circuit designers with an efficient test, modeling, and SPICE-level simulation environment. At the beginning of interconnect technology selection/evaluation, comprehensive and representative 3-D interconnect test structures are designed and fabricated for each technology option. The geometric parameters and their standard deviations are then characterized by measured data using 3-D-simulated ‘thickness vs. capacitance’ curves. A spreadsheet-based Universal Multilevel Interconnect Model Evaluator reads the characterized geometric parameters and generates maximum-, nominal-, and minimum-case parameterized interconnect SPICE subcircuits for each technology to model global and critical VLSI interconnect networks, such as clock trees, power distribution, control/data buses, and word/bit lines. In this way, new interconnect options can be evaluated using rigorous SPICE simulations.
Antibiotic Resistance Patterns of Outpatient Pediatric Urinary Tract Infections (2013)

E. coli remains the most common pediatric uropathogen. Although widely used, trimethoprim-sulfamethoxazole is a poor empirical choice for pediatric urinary tract infections in many areas due to high resistance rates. First-generation cephalosporins and nitrofurantoin are appropriate narrow-spectrum alternatives given their low resistance rates. Local antibiograms should be used to assist with empirical urinary tract infection treatment.