gebhart/patrepeval huggingface dataset:
The differentiation of a potential mesenchymal stem cell population within ovine bone marrow (1994)

Conference Article| August 01 1994 The differentiation of a potential mesenchymal stem cell population within ovine bone marrow HELEN L. JESSOP; HELEN L. JESSOP 1Department of Biochemistry, University of Wales, Cardiff P.O. Box 903, Cardiff CF1 1ST Search for other works by this author on: This Site PubMed Google Scholar BRENDON S. NOBLE; BRENDON S. NOBLE *The Rowett Research Institute, Greenburn Road, Aberdeen AB2 9SB Search for other works by this author on: This Site PubMed Google Scholar ANTHONY CRYER ANTHONY CRYER 1Department of Biochemistry, University of Wales, Cardiff P.O. Box 903, Cardiff CF1 1ST Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1994) 22 (3): 248S. https://doi.org/10.1042/bst022248s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation HELEN L. JESSOP, BRENDON S. NOBLE, ANTHONY CRYER; The differentiation of a potential mesenchymal stem cell population within ovine bone marrow. Biochem Soc Trans 1 August 1994; 22 (3): 248S. doi: https://doi.org/10.1042/bst022248s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
The Research Progress of Targeted Drug Delivery Systems (2017)

Targeted drug delivery system (DDS) means to selectively transport drugs to targeted tissues, organs, and cells through a variety of drugs carrier. It is usually designed to improve the pharmacological and therapeutic properties of conventional drugs and to overcome problems such as limited solubility, drug aggregation, poor bio distribution and lack of selectivity, controlling drug release carrier and to reduce normal tissue damage. With the characteristics of nontoxic and biodegradable, it can increase the retention of drug in lesion site and the permeability, improve the concentration of the drug in lesion site. at present, there are some kinds of DDS using at test phase, such as slow controlled release drug delivery system, targeted drug delivery systems, transdermal drug delivery system, adhesion dosing system and so on. This paper makes a review for DDS.
Tyrosine-kinase expression profiles in human gastric cancer cell lines and their modulations with retinoic acids (2003)

Many protein tyrosine kinases are key regulators involved in cellular growth, differentiation, development, apoptosis and signal transduction pathways. Obtaining a comprehensive tyrosine-kinase expression profile in tumour cells is essential to learning more about their oncogenic potentials and responses to various chemotherapeutic reagents - such as retinoic acid, which has been shown to suppress the growth of gastric cancer cells and modulate gene expression. Expression of tyrosine kinases in retionic acid-treated cancer cells was investigated by reverse trancriptase-polymerase chain reaction (RT-PCR) and a novel restriction analysis of gene expression (RAGE) display technique. We first established comprehensive tyrosine-kinase profiles in different human gastric cancer cell lines. In cells treated with 9-cis-retinoic acid or all-trans-retinoic acid, we found that two PTKs (Eph and Hek5) appeared to be upregulated. In the present study, we demonstrate an efficient and simple RAGE approach for examining tyrosine kinases' expression in tumour cells and their alterations following drug treatments.
<title>Crosslinked anisotropic network based on liquid crystalline precursors as a liquid-crystal-aligning layer</title> (1997)

A new method for achievement of a uniform liquid crystal alignment in conventional sandwich cells is proposed. The method is based on the interaction between a highly anisotropic liquid crystal thermoset material, used as an aligning layer, and liquid crystal. An important advantage of the method is that the contact surface of the alignment layer with the liquid crystal, contrary to the conventional aligning techniques using buffed polymer films, is not subjected to any mechanical treatment before the cell assembling and thus being entirely defect-free. The alignment layers based on anisotropic liquid crystal thermosets are especially important in the case of ferroelectric liquid crystal devices where the surface defects are playing a crucial role.
The Most Advanced Data Mining of the Big Data Era (2012)

Recently, the acquisition of knowledge from big data analysis is becoming an essential feature of business efficiency. However, the analysis of big data can be troublesome because it often involves the collection and storage of mixed data based on different patterns or rules (heterogene ous mixture data). This has made the heterogeneous mixture property of data a very important issue. This paper introduces “heterogeneous mixture learning,” which is the most advanced heterogeneous mixture data analysis technology developed by NEC, together with details of some actual applications. The possibility of the utilization of data that has previously been collected without any specific aim is also discussed.
Quantum Computing of Quantum Chaos and Imperfection Effects (2001)

We study numerically the imperfection effects in the quantum computing of the kicked rotator model in the regime of quantum chaos. It is shown that there are two types of physical characteristics: for one of them the quantum computation errors grow exponentially with the number of qubits in the computer, while for the other the growth is polynomial. A certain similarity between classical and quantum computing errors is also discussed.
757. Antituberculosis agents. Part II. Dehydrobromination products and related bases derived from bis-2 : 3-dibromopropyl sulphide (1956)

D. Edwards and J. B. Stenlake, J. Chem. Soc., 1956, 3892 DOI: 10.1039/JR9560003892
Influencia del nivel de educación sanitaria de los padres o apoderados en el estado de salud e higiene bucal del niño con retardo mental (2014)

El propósito de esta investigación fue evaluar la influencia del nivel de educación sanitaria sobre salud bucal de padres o apoderados sobre el estado de salud e higiene bucal del niño con retardo mental. Se realizó una investigación de tipo analítico y de corte Transversal. La muestra estuvo conformada por 58 niños de ambos géneros con retardo mental leve o moderado entre los 6 y 14 años de edad, quienes acudieron con sus padres o apoderados. La evaluación del nivel de educación sanitaria sobre salud bucal de los padres o apoderados, se realizó mediante un cuestionario semi-estructurado, los que clasificaron en dos grupos, de nivel de educación sanitaria sobre salud bucal bajo y medio, los niños fueron seleccionados intencionalmente y equitativamente por cuotas de acuerdo a los niveles de educación sanitaria de sus padres o apoderados y examinados clínicamente a luz natural, utilizando los siguientes índices epidemiológicos: Caries (CPOD-ceod), Índice de placa dental de Greene y Vermillion modificado (IHOS) y el índice gingival de Löe y Silness modificado (IG) . Al relacionar el Nivel de Educación Sanitaria sobre Salud Bucal de Padres o Apoderados con el estado de salud e higiene bucal de los niños con retardo mental, se observó que el 62,1% de los niños cuyos Padres o Apoderados tuvieron Nivel Bajo de Educación Sanitaria sobre Salud Bucal presentaron un estado de salud e higiene bucal malo en comparación con el 65,5% de los niños cuyos Padres o Apoderados tuvieron Nivel Medio de Educación Sanitaria sobre Salud Bucal que presentaron un estado de salud e higiene bucal regular, se halló diferencia estadísticamente significativa al aplicar la prueba X2 (p=0,036). Por tanto se deduce que el nivel de educación sanitaria sobre salud bucal que poseen los padres o apoderados, está relacionada con el estado de salud e higiene bucal de los niños con retardo mental leve o moderado estudiados.
An Efficient Algorithm for Calculating the Exact Hausdorff Distance (2015)

The Hausdorff distance (HD) between two point sets is a commonly used dissimilarity measure for comparing point sets and image segmentations. Especially when very large point sets are compared using the HD, for example when evaluating magnetic resonance volume segmentations, or when the underlying applications are based on time critical tasks, like motion detection, then the computational complexity of HD algorithms becomes an important issue. In this paper we propose a novel efficient algorithm for computing the exact Hausdorff distance. In a runtime analysis, the proposed algorithm is demonstrated to have nearly-linear complexity. Furthermore, it has efficient performance for large point set sizes as well as for large grid size; performs equally for sparse and dense point sets; and finally it is general without restrictions on the characteristics of the point set. The proposed algorithm is tested against the HD algorithm of the widely used national library of medicine insight segmentation and registration toolkit (ITK) using magnetic resonance volumes with extremely large size. The proposed algorithm outperforms the ITK HD algorithm both in speed and memory required. In an experiment using trajectories from a road network, the proposed algorithm significantly outperforms an HD algorithm based on R-Trees.
Strategies for PLC signal injection in electricity distribution grid transformers (2011)

Distribution transformers are found in secondary substations, and connect to three phase low voltage lines that deliver electricity to points of supply. Electricity customers are charged for their consumption based in the measurements registered in meters present at the point of supply. (PLC) signal injection in key element in PLC signal PRIME is a narrowband PLC band, used by utilities to Power Line Communication distribution transformers is a propagation in distribution grids. technology in CENELEC A communicate with meters at maximum data rates of 122.9 kbps. PRIME technology establishes subnetworks rooting at distribution transformers in secondary substations, where the so called Base Nodes are installed, to communicate with Service Nodes present at meters in Smart Metering environments. This paper analyzes the alternatives for PLC signal injection, either single phase or three phase, through different field tests, in order to improve overall network constitution and performance of meters. The results and conclusions may be extrapolated to any other low voltage PLC technology in the same frequency band. The conclusions of the paper make recommendations to use specific PLC injection configurations, depending on the topologies under study, and provide guidance for product development in this area which has fundamental influence in the results obtained for the PLC communication system.
Quadratic Span Programs and Succinct NIZKs without PCPs. (2012)

We introduce a new characterization of the NP complexity class, called Quadratic Span Programs (QSPs), which is a natural extension of span programs defined by Karchmer and Wigderson. Our main motivation is the construction of succinct arguments of NP-statements that are quick to construct and verify. QSPs seem well-suited for this task, perhaps even better than Probabilistically Checkable Proofs (PCPs). In 2010, Groth constructed a NIZK argument in the common reference string (CRS) model for Circuit-SAT consisting of only 42 elements in a bilinear group. Interestingly, his argument does not (explicitly) use PCPs. But his scheme has some disadvantages – namely, the CRS size and prover computation are both quadratic in the circuit size. In 2011, Lipmaa reduced the CRS size to quasi-linear, but with prover computation still quadratic. Using QSPs we construct a NIZK argument in the CRS model for Circuit-SAT consisting of just 7 group elements. The CRS size is linear in the circuit size, and prover computation is quasi-linear, making our scheme seemingly quite practical. (The prover only needs to do a linear number of group operations; the quasi-linear computation is a multipoint evaluation and interpolation.) Our results are complementary to those of Valiant (TCC 2008) and Bitansky et al. (2012), who use “bootstrapping ” (recursive composition) of arguments to reduce CRS size and prover and verifier computation. QSPs also provide a crisp mathematical abstraction of some of the techniques underlying Groth’s and Lipmaa’s constructions.
Memory-aware sizing for in-memory databases (2014)

In-memory database systems are among the technological drivers of big data processing. In this paper we apply analytical modeling to enable efficient sizing of in-memory databases. We present novel response time approximations under online analytical processing workloads to model thread-level fork-join and per-class memory occupation.We combine these approximations with a non-linear optimization program to minimize memory swapping in in-memory database clusters. We compare our approach with state-of-the-art response time approximations and trace-driven simulation using real data from an SAP HANA in-memory system and show that our optimization model is significantly more accurate than existing approaches at similar computational costs.
Reflections on Staging Sir David Lyndsay's Satire of the Three Estates at Linlithgow Palace, June 2013 (2013)

This article reflects on the discoveries gained from performing the full text of Sir David Lyndsay's A Satire of the Three Estates at Linlithgow Palace in June 2013 as part of the AHRC-funded 'Staging and Representing the Scottish Renaissance Court' project. It describes the nature and aims of the project, and discusses the ways in which recreating the production suggests rather different conclusions about the nature of the play to those created by the seminal revival, directed by Tyrone Guthrie for the Edinburgh International Festival of 1948. By contrasting the two productions, the essay suggests ways in which staging the full text allows rather different political and dramaturgical agenda to emerge to those embraced by Guthrie's necessarily circumscribed version. In particular the role of Pauper emerges as a far more significant and radical figure, capable, like the play as a whole, of addressing contemporary issues and anxieties as powerfully in 2013 as it seems to have done in 1552 and 1554.
ChemInform Abstract: Synthesis of New Cyclophosphazenes Containing Polyoxyethylene Moieties. (1987)

Abstract Reaction of hexachlorocyclophosphazene (I) with the polyethylene glycol mono alkyl ethers (II) yields the hexasubstituted derivatives (III).
CD44, a Cell Surface Chondroitin Sulfate Proteoglycan, Mediates Binding of Interferon-γ and Some of Its Biological Effects on Human Vascular Smooth Muscle Cells (1999)

Several cytokines and growth factors act on cells after their association with the glycosaminoglycan (GAG) moiety of cell surface proteoglycans (PGs). Interferon-gamma (IFN-gamma) binds to GAG; however, the relevance of this interaction for the biological activity of IFN-gamma on human cells remains to be established. Human arterial smooth muscle cells (HASMC), the main cells synthesizing PG in the vascular wall, respond markedly to IFN-gamma. We found that treatment of HASMC with chondroitinase ABC, an enzyme that degrades chondroitin sulfate GAG, reduced IFN-gamma binding by more than 50%. This treatment increased the affinity of 125I-IFN-gamma for cells from a Kd value of about 93 nM to a Kd value of about 33 nM. However, the total binding was reduced from 9. 3 +/- 0.77 pmol/microg to 3.0 +/- 0.23 pmol/mg (n = 4). Interestingly, pretreatment with chondroitinase ABC reduced significantly the cellular response toward IFN-gamma. The interaction of IFN-gamma with chondroitin sulfate GAG was confirmed by affinity chromatography of isolated cell-associated 35S-, 3H-labeled PG on a column with immobilized IFN-gamma. The cell-associated PG that binds to IFN-gamma was a chondroitin sulfate PG (CSPG). This CSPG had a core protein of approximately 110 kDa that was recognized by anti-CD44 antibodies on Western blots. High molecular weight complexes between IFN-gamma and chondroitin 6-sulfate were observed in gel exclusion chromatography. Additions of chondroitin 6-sulfate to cultured HASMC antagonized the antiproliferative effect and expression of major histocompatibility complex II antigens induced by IFN-gamma. These results indicate that IFN-gamma binds with low affinity to the chondroitin sulfate GAG moiety of the cell surface CSPG receptor CD44. This interaction may increase the local concentration of IFN-gamma at the cell surface, thus facilitating its binding to high affinity receptors and modulating the ability of IFN-gamma to signal a cellular response.
Proton and electron transfer in the acceptor quinone complex of photosynthetic reaction centers from Rhodobacter Sphaeroides (2004)

For twenty years the photosynthetic reaction center (RC) has been the premier testing ground for theoretical understanding of electron transfer in aperiodic systems, with special, but not unique, reference to long distance biological electron transport. In addition to the known structure, many of the attributes that make RCs so well suited to studying electron transfer function equally well for any charge movement, including protons. These include the presence of intrinsic reporter groups (electrochromically active pigments), high time resolution through light activation, and a large number and variety of distinct reactions, ranging from loosely coupled responses of the protein dielectric to specific, long distance proton transfers in and out of active sites, and bond making in terminal chemical transformations. A wide variety of biophysical methods have been coupled with site directed mutagenesis to reveal mechanisms of proton uptake, transfer and chemistry in the RC. This review summarizes our progress to date, which suggests that the RC can serve as a paradigm, not only for many energy coupled, membrane proteins, but for the electrostatic and dielectric properties of proteins that are critical to their general function.
In vitro fertilization in domestic and non-domestic cats including sequences of early nuclear events, development in vitro, cryopreservation and successful intra- and interspecies embryo transfer. (1993)

The domestic cat may be used as a model for developing assisted reproduction techniques including in vitro fertilization (IVF), embryo culture, cryopreservation and embryo transfer (ET) for application to threatened and endangered species of non-domestic cats. Interoestrous domestic cats were injected with a total of 1.0-6.0 mg follicle-stimulating hormone (FSH) daily for 4 days and with 100 iu human chorionic gonadotrophin (hCG) on day 5. Follicular oocytes recovered at 26 +/- 1 h after hCG were co-incubated for 4-6 h at 38 degrees C in 5% CO2 with spermatozoa (1-2 x 10(5) motile spermatozoa ml-1) collected by artificial vagina. To determine the timing of sperm penetration and early fertilization events in vitro, oocytes were fixed and examined at intervals from 0.5 to 10 h after sperm exposure. The penetration rate of metaphase II (MII) oocytes at 0.5-3 h was equivalent to that at 3-6 h (95 versus 96%). Second polar body extrusion, pronuclear formation and apposition were observed at 2, 6-8 and 10 h, respectively. Simple (Tyrode's) and complex (F-10, M-199 and CMRL-1066) culture media with 10% fetal calf serum were compared for their ability to support development to the morula or blastocyst stage during culture periods of 96-168 h after IVF. The average number of cells per embryo was similar (P > 0.05) in the various media at each interval except that CMRL-1066 reduced (P < 0.05) development at 96 h if it was used before the two-cell stage. In F-10, neither the presence of intact cumulus cells nor changing to fresh F-10 medium at 48 h affected development at 96 h. Blastocyst development at 168 h was similar in both F-10 (18%) and Tyrode's (26%). To determine developmental ability in vivo, IVF-derived embryos (n = 586) were transferred at 96 or 120 h to recipients (n = 49) that had undergone synchronous oocyte recovery as donors. The percentage of recipients producing kittens after transfer of embryos cultured for 96 or 120 h in F-10 was 31 and 25, respectively, compared with 55% of 120 h recipients receiving embryos cultured in M-199 or Tyrode's. Overall, more pregnancies occurred following transfer of > or = 12 embryos (11/26) than if < 12 embryos were transferred (6/23).(ABSTRACT TRUNCATED AT 400 WORDS)
Longitudinal Clinical Evaluation of Adjunct Minocycline in the Treatment of Chronic Periodontitis (2006)

Our findings demonstrated that both therapies reduced mean PD from 90 to 360 days; however, SRP combined with the use of subgingival minocycline showed a higher reduction at 270 and 360 days following therapy.
Molecular-Based Methods for Quantifying HIV Viral Load (2004)

Viral load quantitation has become the major prognostic marker for disease prognosis and outcome of antiretroviral therapy in the treatment of HIV-infected individuals. The three major methodologies for viral load quantitation: the reverse transcriptase-polymerase chain reaction (RT-PCR; Amplicor HIV-1 Monitor Test, Roche Diagnostic Systems, Pleasanton, CA), the nucleic acid sequence-based amplification (NASBA; NucliSens HIV-1 QT Test, Organon Teknika, Bostel, The Netherlands); and a signal amplification methodology termed branchedchain DNA (bDNA) technique (Quantiplex HIV-1 RNA test, Bayer Diagnostics, Emeryville, CA) are briefly reviewed here.
Weather Derivatives for Specific Event Risks in Agriculture (2001)

This paper examines the economics and pricing of weather derivatives in Ontario and argues that weather derivatives and weather insurance can be used as a form of agricultural insurance. Using historical data, the relationship between crop productivity and weather is examined. Then a variety of put and call options for rain- and heat-based weather risk are discussed and numerically evaluated. The evaluation examines in detail the pricing of insurance contracts at a given location and across space.
Single-to-three-phase direct AC/AC modular multilevel converters with integrated split battery energy storage for railway interties (2015)

This paper presents a global hierarchized control method for railway interties based on the direct single-to-three-phase AC/AC Modular Multilevel Converter with integrated split battery energy storage. The power and voltage decoupling between the converter submodules and the batteries is achieved through non-isolated dedicated DC/DC converters. The control objectives include submodule capacitor voltage and battery state of charge balancing. All possible converter operation modes are investigated by means of simulations. Moreover, potential three-phase grid asymmetries are considered and studied. In the latter, the integrated storage elements can be utilized to transfer the necessary active power to the railway network side irrespectively from three-phase grid faults.
Acoustically active surfaces using piezorubber (1991)

The use of single and double layers of piezoelectric material to form acoustically active surfaces for the elimination of reflected and transmitted waves is first discussed from a theoretical standpoint. Experiments are then described in which the piezoelectric composite piezorubber is used as the transducing material in single and double layer active surfaces. It is demonstrated that with the single layer, either reflection or transmission can be eliminated, while both reflection and transmission can practically be eliminated with the double layer. The electrical driving signals applied to the active surfaces in order to accomplish this are shown to agree well with theoretical models using material parameters for piezorubber determined from impedance measurements.