gebhart/patrepeval huggingface dataset:
The relationship between middle ear pressure and deviated nasal septum (1993)

The deviated nasal septum may be associated with middle ear problems, particularly on the side of nasal obstruction. This study aims to find out whether middle ear pressure (MEP) correlates with the degree of nasal obstruction secondary to a deviated nasal septum, and to examine changes in MEP following septal surgery. Patencies of the nasal passages (measured with a peak nasal inspiratory flowmeter) and MEP (measured with a tympanometer) of 55 patients were obtained prior to surgery and 7.5 (6-10) months post-operatively [median (range)]. Forty patients completed the study. Results were analysed by linear regression. In the ear on the side of nasal blockage, MEP was -25.7 +/- 28.4 mm water pre-operatively, and following surgery increased significantly to -2.9 +/- 30.4 mm water (mean +/- SD) (P < 0.001). Pre-operatively, it was inversely related to the difference in patencies between the two nasal passages (r = -0.32, P < 0.02). Post-operatively, its improvement correlated with the degree of reduction of asymmetry of airway patency (r = 0.56, P < 0.001).
<i>Helicobacter pylori</i> lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells (2004)

Primary cultures of guinea pig gastric mucosal cells express NADPH oxidase 1 (Nox1), a homolog of gp91(phox), and produce superoxide anion (O2-) at a rate of approximately 100 nmol.mg protein(-1).h(-1) in response to Helicobacter pylori (H. pylori) lipopolysaccharide (LPS) from virulent type I strains. The upregulated O2- production also enhances H. pylori LPS-stimulated tumor necrosis factor-alpha or cyclooxygenase-2 mRNA expression, which suggests a potential role for Nox1 in the pathogenesis of H. pylori-associated diseases. The H. pylori LPS-stimulated O2- production in cultured gastric mucosal cells was inhibited by actinomycin D as well as cycloheximide, suggesting that the induction is regulated at the transcriptional level. The LPS treatment not only increased the Nox1 mRNA to a greater extent but also induced expression of the message-encoding, Nox-organizing protein 1 (NOXO1), a novel p47phox homolog required for Nox1 activity. In addition, H. pylori LPS activated Rac1; i.e., it converted Rac1 to the GTP-bound state. A phosphoinositide 3-kinase inhibitor, LY-294002, blocked H. pylori LPS-induced Rac1 activation and O2- generation without interfering with the expression of Nox1 and NOXO1 mRNA. O2- production inhibited by LY-294002 was completely restored by transfection of an adenoviral vector encoding a constitutively active Rac1 but not an inactive Rac1 or a constitutively active Cdc42. These findings indicate that Rac1 plays a crucial role in Nox1 activation. Thus the H. pylori LPS-stimulated O2- production in gastric mucosal cells appears to require two distinct events: 1) transcriptional upregulation of Nox1 and NOXO1 and 2) activation of Rac1.
Food-grade Pickering emulsions stabilised with solid lipid particles (2016)

Aqueous dispersions of tripalmitin particles (with a minimum size of 130 nm) were produced, via a hot sonication method, with and without the addition of food-grade emulsifiers. Depending on their relative size and chemistry, the emulsifiers altered the properties of the fat particles (e.g. crystal form, dispersion state and surface properties) by two proposed mechanisms. Firstly, emulsifiers modify the rate and/or extent of polymorphic transitions, resulting in the formation of fat crystals with a range of polarities. Secondly, the adsorption of emulsifiers at the particle interface modifies crystal surface properties. Such emulsifier-modified fat particles were then used to stabilise emulsions. As the behaviour of these particles was predisposed by the kind of emulsifier employed for their manufacture, the resulting particles showed different preferences to which of the emulsion phases (oil or water) became the continuous one. The polarity of the fat particles decreased as follows: Whey Protein Isolate > Soy Lecithin > Soy Lecithin + Tween 20 > Tween 20 > Polyglycerol Polyricinoleate > no emulsifier. Consequently, particles stabilised with WPI formed oil-in-water emulsions (O/W); particles stabilised solely with lecithin produced a highly unstable W/O emulsion; and particles stabilised with a mixture of lecithin and Tween 20 gave a stable W/O emulsion with drop size up to 30 μm. Coalescence stable, oil-continuous emulsions (W/O) with drop sizes between 5 and 15 μm were produced when the tripalmitin particles were stabilised with solely with Tween 20, solely with polyglycerol polyricinoleate, or with no emulsifier at all. It is proposed that the stability of the latter three emulsions was additionally enhanced by sintering of fat particles at the oil-water interface, providing a mechanical barrier against coalescence.
Personal and peripatetic health promotion reflections. -editorial- (2002)

The author reflects on health promotion in Canada, the United States and Brazil. (non-author abstract)
RNA interference-based nanosystems for inflammatory bowel disease therapy (2016)

Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is a chronic, recrudescent disease that invades the gastrointestinal tract, and it requires surgery or lifelong medicinal therapy. The conventional medicinal therapies for IBD, such as anti-inflammatories, glucocorticoids, and immunosuppressants, are limited because of their systemic adverse effects and toxicity during long-term treatment. RNA interference (RNAi) precisely regulates susceptibility genes to decrease the expression of proinflammatory cytokines related to IBD, which effectively alleviates IBD progression and promotes intestinal mucosa recovery. RNAi molecules generally include short interfering RNA (siRNA) and microRNA (miRNA). However, naked RNA tends to degrade in vivo as a consequence of endogenous ribonucleases and pH variations. Furthermore, RNAi treatment may cause unintended off-target effects and immunostimulation. Therefore, nanovectors of siRNA and miRNA were introduced to circumvent these obstacles. Herein, we introduce non-viral nanosystems of RNAi molecules and discuss these systems in detail. Additionally, the delivery barriers and challenges associated with RNAi molecules will be discussed from the perspectives of developing efficient delivery systems and potential clinical use.
An Efficient Evolution Method from a TDM-PON with a Video Overlay to NGA (2008)

An evolution method from a TDM-PON with a video overlay to NGA is demonstrated. A single type of 374-port WC enables a simple evolution of TDM-PON with a video overlay maintaining OSP and wavelength plan.
High Levels of Antigen-Specific Islet Antibodies Predict Futureβ -Cell Failure in Patients with Onset of Diabetes in Adult Age<sup>1</sup> (2001)

It is unclear whether high levels of antigen-specific islet antibodies [GADA (glutamic acid decarboxylase 65 antibodies) and IA2-ab (protein tyrosine phosphatase-like protein antibodies)] predict beta-cell failure in patients with onset of diabetes in adult age. Therefore, GADA and IA2-ab levels at the diagnosis of diabetes were related to fasting plasma C-peptide levels 5 yr later in 148 patients with diabetes onset in adult age (age at onset, 20-77 yr; median, 57 yr). Classical islet cell antibodies (ICA) were also determined. Complete beta-cell failure (undetectable fasting plasma C-peptide) was only present in 4 patients at diagnosis of diabetes, but in 21 patients 5 yr thereafter. At diagnosis, ICA were detected in 20 of 21 (95%) patients with beta-cell failure after 5 yr and in only 7 of 127 (5%) without, whereas GADA and/or IA2-ab (>97.5 percentile of healthy controls) were detected in all 21 (100%) with but also in 23 of 127 (18%) patients without beta-cell failure after 5 yr. Thus, ICA had a higher positive predictive value (74%) than GADA and/or IA2-ab (47%; P < 0.05). With high cutoff values for GADA and IA2-ab, however, GADA and/or IA2-ab were detected in 19 of 21 (90%) patients with beta-cell failure vs. only in 5 of 127 (4%) without, giving a positive predictive value of 79%. Slightly elevated GADA levels in IA2-ab-negative patients were associated with progressive but not complete beta-cell failure within the study period. Hence, high GADA and/or IA2-ab levels predict a future complete beta-cell failure, whereas low GADA levels predict slowly progressive beta-cell insufficiency.
Antibody to the Rheumatoid Arthritis Nuclear Antigen (1980)

Most patients with seropositive rheumatoid arthritis, and a variable but lesser percentage of normal subjects, have precipitating antibodies to a nuclear antigen, rheumatoid arthritis nuclear antigen, present in Epstein-Barr virus-infected human B lymphoblastoid cells. We have used a sensitive indirect immunofluorescence assay for antibody to rheumatoid arthritis nuclear antigen in a study of patients with infectious mononucleosis and healthy control subjects. Of 110 sera from normal, college-age cadets, 58 were from individuals without prior Epstein-Barr virus infection, as indicated by the lack of antibody to viral capsid antigen. All of these also lacked activity to rheumatoid arthritis nuclear antigen. 52 sera were positive for antibody to viral capsid antigen, and antibody to rheumatoid arthritis nuclear antigen was present in 26 (50%) of these. In 67 sequential sera from 11 college-age students with infectious mononucleosis who became positive for antibody to rheumatoid arthritis nuclear antigen, only 2 were positive during the 1 mo. Thereafter the incidence and titers increased progressively through the 1st yr after infection. This time-course resembled that for the development of antibody to Epstein-Barr nuclear antigen, another transformation antigen in Epstein-Barr virus-infected B lymphocytes. The development of positivity for both was much later than that of antibody to the structural viral capsid antigen, which in the current study was always positive by 1 wk. Thus, antibody to rheumatoid arthritis nuclear antigen is present in a large proportion of normal individuals and can now be clearly ascribed, from both in vivo and in vitro studies, to prior infection with Epstein-Barr virus.
Single Frequency Networks in DTV (2005)

Single Frequency Networks (SFNs) offer many advantages including better coverage, less interference, less power, and higher reliability. SFNs can also free up extra TV channels, resulting in more efficient use of the spectrum. The paper presents an overview of the advantages of SFNs and some basics about how to implement them. The significantly improved Signal to Interference performance and less radiated power in SFNs are derived from simple propagation models. Some potential problems that must be considered are discussed, including limitations due to receiver performance. Several simple formulas that should be helpful in quickly estimating and evaluating an SFN system are also presented. Finally, the likely implications of SFNs are covered, in particular the need for changed FCC rules and increased competition through a higher frequency reuse. The idea of the FCCs only limiting the power outside of the service area and letting the broadcasters decide on transmitter locations, number of transmitters and power levels is proposed.
The action of creatinol 0-phosphate on the inotropic effect of isoprenaline in isolated rat atria and in anesthetized dogs. (1979)

The action of N-methyl-N-(beta-hydroxyethyl) guanidine O-phosphate (creatinol O-phosphate) was studied on the contractility of the heart, in vitro on isolated rat atria and in vivo in anesthetized dogs. Creatinol O-phosphate was without action on the contractility of isolated rat atria stimulated by isoprenaline 10(-8) mol/l which produced the maximum inotropic effect. Creatinol O-phosphate increased the contractility evoked by isoprenaline 10(-5) mol/l and impaired the development of the negative inotropic effect evoked by prolonged treatment with this large dose. In dogs, creatinol O-phosphate pretreatment increased the positive inotropic effect of large but not low isoprenaline dosages. It is concluded that creatinol O-phosphate increased the contractile efficiency of the heart submitted to the action of an excess of catecholamines.
Oxidation of EDTA with H<sub>2</sub>O<sub>2</sub>catalysed by metallophthalocyanines (2009)

The oxidation of ethylenediaminetetraacetic acid (EDTA) and Na, Ca, Zn, Fe, and Mn EDTA complexes with hydrogen peroxide was studied in aqueous solution with the use of several metallophthalocyanines (MePcS) as catalysts. The impact of pH, temperature, and catalyst/substrate ratio were investigated. The most effective catalytic system under neutral conditions was FePcS- H2O2. In these laboratory-scale experiments, a catalyst/substrate/H2O2 molar ratio of 4:100:2000 was found to be optimal, while the effective reaction temperature was 40-60 degrees C. When the impact of metal speciation was studied, metal-specific degradation rates in the removal of these compounds were observed: all EDTA-metal complexes except Zn-EDTA were efficiently oxidized within three hours. The most degradable species was Fe(III)-EDTA. Among the catalysts, FePcS was found to be the most active in EDTA degradation. Over 90% of EDTA was removed in the presence of FePcS as catalyst within three hours of reaction time.
Effect of Inoculation Time and Population Density of Pseudomonas agarici and P. tolaasii on the Mycelial Growth and the Fruit body Formation in Flammulina velutipes (1998)

The effect of P. agarici and P. tolaasii causing the bacterial disease of mushrooms on the mycelial growth and fruitbody formation of F. velutipes was evaluated in laboratory. When the pathogenic bacteria was inoculated simultaneously with F. velutipes or 5 days after inoculation of F. velutipes, they significantly deterred both mycelial growth and fruitbody formation of F. velutipes in sawdust culture and showed strong inhibition under high population density. They appeared to be tender or milky in exhibiting symptom on F. velutipes by inoculating the concentration of of unit/g media, and their growth seemed to be stopped under media. On media of P. agarici and media of P. tolaasii, there was no effect on the fruitbody yield of F. velutipes. P. tolaasii was more suppressive in the mycelial growth of F. velutipes than P. agarici, while on fruitbodies formation of F. velutipes, P. agarici showed slightly higher inhibition than that of P. tolaasii. When the bacteria was inoculated 10 days after inoculation of F. velutipes, both mycelial growth and fruit body formation were not affected nearly.
Expression of tumour necrosis factor alpha and accumulation of fibronectin in coronary artery restenotic lesions retrieved by atherectomy. (1995)

Restenosis is associated with increased expression of tumour necrosis factor alpha and fibronectin, suggesting that an immune-inflammatory reaction probably contributes to neointimal formation and may represent a form of wound healing and repair secondary to mechanical injury.
Boundary mode lubrication of articular cartilage by recombinant human lubricin (2008)

Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant. It is unclear how lubricin boundary lubricates a wide range of bearings from tissue to artificial surfaces, and if the mechanism is the same for both soluble and bound lubricin. In the current study, experiments were conducted to investigate the hypothesis that recombinant human lubricin (rh-lubricin) lubricates cartilage in a dose-dependent manner and that soluble and bound fractions of rh-lubricin both contribute to the lubrication process. An rh-lubricin dose response was observed with maximal lubrication achieved at concentrations of rh-lubricin greater than 50 microg/mL. A concentration-response variable-slope model was fit to the data, and indicated that rh-lubricin binding to cartilage was not first order. The pattern of decrease in equilibrium friction coefficient indicated that aggregation of rh-lubricin or steric arrangement may regulate boundary lubrication. rh-lubricin localized at the cartilage surface was found to lubricate a cartilage-glass interface in boundary mode, as did soluble rh-lubricin at high concentrations (150 microg/mL); however, the most effective lubrication occurred when both soluble and bound rh-lubricin were present at the interface. These findings point to two distinct mechanisms by which rh-lubricin lubricates, one mechanism involving lubricin bound to the tissue surface and the other involving lubricin in solution.
Formal models for embedded system design (2000)

The authors give an overview of models of computation for embedded system design and propose a new model that supports communication-based design. An essential component of a new system design paradigm is the orthogonalization of concerns (i.e., the separation of the various aspects of design to allow more effective exploration of alternative solutions). The pillars of the design methodology that we have proposed over the years are the separation between function (what the system is supposed to do) and architecture (how it does it) and the separation between computation and communication.
Sandwiched grating for high efficiency with wide bandwidth and polarization independence (2012)

We describe novel sandwiched grating for high efficiency with polarization independence. The grating parameters can be optimized based on modal method and rigorous coupled-wave analysis (RCWA). According to modal method, grating period and duty cycle are prescribed for polarization independence by excited modes with different effective indices. Using RCWA, accurate grating depth and covering layer thickness are optimized by numerical calculation. The sandwiched grating can show high efficiency for both TE and TM polarizations with the optimized grating period, duty cycle, depth, and covering layer thickness. Most importantly, wideband property can be obtained for operation around the central wavelength of 800 nm. The presented novel sandwiched grating can have merits of high efficiency, polarization independence, and wideband property, which should be of great significance for numerous applications.
Modeling white light-emitting diodes with phosphor layers (2006)

With a blue light-emitting diode and a phosphor layer to downconvert blue light to a second light, such as yellow, white light can be produced. The authors developed a one-dimensional model to describe the light propagating in the phosphor layer in terms of light absorption, conversion, and reflection. The parameters required for the model were determined from the data obtained by using multiple-layer phosphor films. The model predicts that, with a reflector between the diode and the phosphor layer that is blue-light transparent but reflects other visible light, the normalized white light intensity is above 0.9, higher than that of conventional packages (0.6–0.8).
Changes in activity of superoxide dismutase and catalase within cereal aphids in response to plant <i>o</i>‐dihydroxyphenols (2007)

Abstract: Superoxide dismutase and catalase activity was found in the bird cherry‐oat aphid, Rhopalosiphum padi (L.) and the grain aphid, Sitobion avenae (F.). Among the aphid morphs studied, the highest activity of the antioxidant enzymes was noted for winged adults (alatae) and the lowest for wingless (apterae) ones. Higher activity of superoxide dismutase and catalase was observed in the polyphagous species R. padi that alternates between woody host plants and grasses. On some ocassions, activity of superoxide dismutase in cereal aphids was increased by twofold, when aphids were exposed to toxic plant o ‐dihydroxyphenols. An opposite tendency was observed in case of activity of the catalase that was strongly reduced within body of phenolics‐treated insects. Among the plant allelochemicals studied, caffeic acid showed the strongest effect on the activity of the antioxidant enzymes of the cereal aphids. The experiments carried out indicate that antioxidant enzymes might play an important role in interactions between cereal aphids and their host plants.
Jamming transition in a highly dense granular system under vertical vibration (2005)

The dynamics of the jamming transition in a three-dimensional granular system under vertical vibration is studied using diffusing-wave spectroscopy. When the maximum acceleration of the external vibration is large, the granular system behaves like a fluid, with the dynamic correlation function G (t) relaxing rapidly. As the acceleration of vibration approaches the gravitational acceleration g , the relaxation of G (t) slows down dramatically, and eventually stops. Thus the system undergoes a phase transition and behaves like a solid. Near the transition point, we find that the structural relaxation shows a stretched exponential behavior. This behavior is analogous to the behavior of supercooled liquids close to the glass transition.
Parameter networks: Towards a theory of low level vision (1981)

One of the most fundamental problems in vision is segmentation; the way in which parts of an image are perceived as a meaningful whole. Recent work has shown how to calculate images of physical parameters from raw intensity data. Such images are known as intrinsic images, and examples are images of velocity (optical flow), surface orientation, occluding contour, and disparity. The principal difficulty with intrinsic images is that each by itself is generally underconstrained; they can only be computed in parallel with each other and with the use of parameters obtained through segmentation. While intrinsic images are not segmented, they are distinctly easier to segment than the original intensity image. If parts of these images are organized in some way, this organization can be detected by a general Hough transform technique. Networks of feature parameters are appended to the intrinsic image organization. Then the intrinsic image points are mapped into these networks. This mapping will be many-to-one onto interesting parameter values. This basic relationship is extended into a general representation and control technique with the addition of three main ideas: abstraction levels; sequential search; and tight coupling. These ideas are a nucleus of a theory of low-level and intermediate-level vision. This theory explains segmentation in terms of highly parallel cooperative computation among intrinsic images and a set of parameter spaces at different levels of abstraction. (Author)