Thiazide Diuretics and Osteoporosis: Time for a Clinical Trial? (1991)

Editorial1 July 1991Thiazide Diuretics and Osteoporosis: Time for a Clinical Trial?Wayne A. Ray, PhDWayne A. Ray, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-1-64 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFracture of the proximal femur (hip) is the osteoporotic fracture with the most pronounced adverse medical and economic consequences. This injury takes its greatest toll among persons 65 years of age or older, a group that in the United States incurs more than 200 000 hip fractures annually, resulting in direct medical care costs of approximately $6 billion (1). In this population, the age-specific incidence of hip fracture doubles every 5 to 7 years, so that between the ages of 65 and 90 years there is a 20-fold increase in incidence (2). Over this same age range, proximal femur bone...References1. 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Ray, PhDAffiliations: Vanderbilt University School of Medicine Nashville, TN 37232 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssociation of Hypertension and Bone Mineral Density in an Elderly African American Female PopulationThiazide diuretics and the risk of hip fracturePostmenopausal Endogenous and Exogenous Hormones, Degree of Obesity, Thiazide Diuretics, and Risk of OsteoporosisHydrochlorothiazide reduces loss of cortical bone in normal postmenopausal women: a randomized controlled trialThiazide Diuretics Affect Osteocalcin Production in Human Osteoblasts at the Transcription Level Without Affecting Vitamin D3 ReceptorsTherapy with Vitamin D Metabolites, Sodium Fluoride, Thiazides, and IsoflavonesUse of Diuretics in Disorders of Calcium MetabolismExpression of the sodium-chloride cotransporter in osteoblast-like cells: effect of thiazide diureticsOsteoporosis from the Perspective of a NephrologistGender considerations in hypertension pathophysiology and treatmentUrinary incontinence: a minor risk factor for hip fractures in elderly womenCurrent use of thiazide diuretics and prevention of femur fracturesThiazide diuretics and fractures: Can meta-analysis help?Age-related OsteoporosisCALCIUM, ESTROGEN, AND PROGESTIN IN THE TREATMENT OF OSTEOPOROSISThe Effects of Thiazide Diuretics on Calcium Metabolism in the AgedMetabolic effects of thiazide and 1,25-(OH)2 vitamin D in postmenopausal osteoporosisThe Effect of Chlorothiazide on Bone-Related Biochemical Variables in Normal Post-Menopausal WomenPsychotropics, thiazide diuretics and hip fractures in the elderlyOsteoporosisThe Prevention and Treatment of OsteoporosisGeriatric hyponatremiaDiuretic drugs 1 July 1991Volume 115, Issue 1Page: 64-65KeywordsBoneClinical trialsDiureticsFemurFood and Drug AdministrationHipHip fracturesOsteoporosisPreventive medicine ePublished: 1 December 2008 Issue Published: 1 July 1991 PDF downloadLoading ...