gebhart/patrepeval huggingface dataset:
Enzyme-instructed self-assembly of taxol promotes axonal branching (2015)

Axonal branching is important for vertebrate neuron signaling. Taxol has a biphasic effect on axonal branching (i.e., high concentration inhibits axonal growth but low concentration restores it). To the best of our knowledge, low concentration of taxol to promote axonal branching has not been reported yet. Herein, we rationally designed a taxol derivative Fmoc-Phe-Phe-Lys(taxol)-Tyr(H2PO4)-OH (1) which could be subjected to alkaline phosphatase (ALP)-catalyzed self-assembly to form taxol nanofibers. We found that, at 10 μM, 1 has a microtubule (MT) condensation effect similar to that of taxol on mammalian cells but with more chronic toxicity than taxol on the cells. At a low concentration of 10 nM, 1 not only promoted neurite elongation as taxol did but also promoted axonal branching which was not achieved by using taxol. We propose that self-assembly of 1 along the MTs prohibited their lateral contacts and thus promoted axonal branching. Our strategy of enzyme-instructed self-assembly (EISA) of a taxol derivative provides a new tool for scientists to study the morphology of neurons, as well as their behaviours.
Non-invasive markers of gut wall integrity in health and disease (2010)

The intestinal mucosa is responsible for the absorption of nutrients from the lumen and for the separation of the potentially toxic luminal content (external environment) from the host (internal environment). Disruption of this delicate balance at the mucosal interface is the basis for numerous (intestinal) diseases. Experimental animal studies have shown that gut wall integrity loss is involved in the development of various inflammatory syndromes, including post-operative or post-traumatic systemic inflammatory response syndrome, sepsis, and multiple organ failure. Assessment of gut wall integrity in clinical practice is still a challenge, as it is difficult to evaluate the condition of the gut non-invasively with currently available diagnostic tools. Moreover, non-invasive, rapid diagnostic means to assess intestinal condition are needed to evaluate the effects of treatment of intestinal disorders. This review provides a survey of non-invasive tests and newly identified markers that can be used to assess gut wall integrity.
Applying quantum interference to EDST medicine testing (1996)

Both traditional meridian theory and modern applications such as the electrodermal screening test (EDST) demonstrate an essential link between bioinformation and meridian phenomena. From the theoretical and clinical work thus far performed by many researchers, it is clear that meridians and bioinformation are essential elements of the functioning of the human body. There are many possible clinical applications of the human meridian system and the body's bioinformational processes, including differential diagnosis and therapy to individual patients which is practicable, systematic, and effective, even in the case of complex, multifaceted medical conditions. Although this article is almost entirely theoretical, it is in complete agreement with, and helps illuminate, numerous clinical studies. It is the author's hope that because of this agreement between theory and practice, modern society is much closer to realizing a broad scientific acceptance of all facets of the meridian theory and the EDST, including medical testing.
Pharmacological and behavioral treatments of cocaine dependence: controlled studies. (1988)

The cocaine epidemic has stimulated novel treatments aimed at reducing relapse to this extremely addicting drug. After detoxification and standard treatment, former cocaine users continue to exhibit strong cocaine craving and physiological changes when presented with cocaine-related stimuli. Because these conditioned responses may increase the risk of relapse, a new treatment has been developed to extinguish such responses. The extinction process, consisting of repeated presentations of cocaine-related stimuli until the stimuli gradually lose their ability to evoke conditioned responses, is integrated into a comprehensive rehabilitation program. Cocaine dependence is often combined with opiate dependence. Desipramine has been added to methadone maintenance in an attempt to reduce dependence on both substances. Methadone impedes catabolism of desipramine so that relatively low doses of desipramine may produce antidepressant effects and possibly reduce the desire to use cocaine. Preliminary evidence from a placebo-controlled study of desipramine in combination with methadone suggests that desipramine produces significant improvements in psychological functioning, but its effects on reduction of cocaine use are less dramatic.
Lateral shelf acetabuloplasty in Perthes’ disease (1999)

The surgical treatment of Perthes’ disease by femoral or innominate osteotomy is not as effective in those over the age of eight years as it is in the younger child. This has prompted the search for other types of management in those who are older. The preliminary results of the use of a lateral shelf acetabuloplasty for such cases have shown encouraging results at two years. The concern with such an operation is that it might interfere with the growth of the outer aspect of the acetabulum and so prejudice the long-term outcome. We describe a review at maturity of 26 children presenting with early disease after the age of eight years who were treated by lateral shelf acetabuloplasty. The results suggest that the outcome is improved; 22 of 27 hips were rated as Stulberg groups 1 to 3. Poor results occurred in children, particularly girls, presenting with Group-4 disease over the age of 11 years.
Ampullosporins B, C, D, E1, E2, E3, and E4, from Sepedonium ampullosporum HKI-0053. Structures and Biological Activities. (2001)

In a previous paper1) we reported the new peptaibol-type antibiotic ampullosporin A (1, Fig. Ampullosporin A (1)
A study of electrostatic force nonlinearities in resonant microstructures (2008)

This letter investigates the nature of amplitude frequency (A-f) dependence caused by nonlinearities in the parallel plate electrostatic transduced in resonant microstructures. We present analytical and experimental evidences that the A-f nonlinearities are practically always dominated by third order nonlinear terms. For an electrostatically unbalanced system, we show that the bias voltage at which second and third order nonlinearities have equal impact on A-f dependence corresponds to ∼90% of the dc pull-in voltage.
Hydrolysis of Phosphatidylcholine in Aerosol-OT/Isooctane Reversed Micelles by Phospholipase $A_2$ (1997)

Bee venom (Apis mellifera) phospholipase solubilized in reversed micelles containing small amount of water stabilized by surfactant could catalyze the hydrolysis of dipalmitoyl phosphatidylcholine (DPPC). A sensitive and simple high performance liquid chromatographic (HPLC) methodology of phospholipase assay for the hydrolysis of DPPC was developed. Kinetic analysis of the phospholipase -catalyzed reaction was found to be possible in reversed micelles. Among the surfactants and organic solvents tested, aerosol-OT and isooctane were most effective for the hydrolysis of DPPC in reversed micelles. Optimal temperature, optimal pH, and activation energy were determined to be , 7.0, 8.73 mM, 2.83 units/㎎ protein and 12.31 kcal/mole, respectively. The hydrolysis activity was dependent on water content and maximum activity was obtained at R value (=[water]/[aerosol-OT]) of 10.0.
Relationship between Doxorubicin-Induced Ecg Changes and Myocardial Alterations in Rats (1986)

The aim of the present study was to evaluate the dose- and time-dependence of the effect displayed by doxorubicin (DXR) on the electrocardiogram (ECG) and to establish the relationship between structural alterations of the myocardium and ECG changes in rats administered DXR, at a dose of 1.5 or 3.0 mg/kg, every 3 days for a total of three administrations. The most interesting findings consisted of a dose-dependent, but reversible prolongation of the QRS complex, and in a dose-dependent and progressive irreversible increase in QaT and, in particular, in SaT duration. Furthermore, animals treated with the higher DXR dose showed a slight increase in serum K+ concentration and a significant decrease in serum Ca2+ levels. A good correlation was found between the morphologic score indicating the degree of observed tissue damage and SaT prolongation. These results therefore support the usefulness of measuring this ECG parameter for monitoring the development of DXR-induced cardiotoxicity in rats.
Distributed optical fiber sensors and their applications (2008)

This paper contains the theory behind optical fiber sensing measurement and the latest trends in optical fiber sensing measurement and its applications. Smart structures and materials in which an optical fiber acts as a sensor to measure distributed strain and/or temperature along the fiber have applications in health monitoring functions, such as preventive maintenance, product efficiency improvement, and maintenance cost reduction. Furthermore, optical fiber has the advantage that it is essentially explosion-proof, needs no electric power supply, and is not affected by outside noise, such as lightening or high-voltage electrical power lines. This makes optical fiber suitable for plant and civil applications.
BICMOS circuit technology for high speed DRAMs (1987)

In the development of high density DRAMs such as 1 M bit or beyond, it will be increasingly important to achieve high speed, competitive to SRAMs, in addition to low cost per bit. Recently, BIPOLAR CMOS (BICMOS) technology has been proposed for achieving high speed and low power operation, especially SRAMs (1,2).
High‐throughput allelic discrimination of B and Q biotypes of the whitefly, <i>Bemisia tabaci</i>, using TaqMan allele‐selective PCR (2007)

The development of this rapid and high-throughput assay has important potential for routine monitoring of B and Q biotypes on ornamental plants and for the screening of B. tabaci populations in countries where these biotypes are not yet established.
Edge detection in micrometrology with nearly confocal microscopy (1984)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. J. R. Sheppard, I. J. Cox, and D. K. Hamilton, "Edge detection in micrometrology with nearly confocal microscopy," Appl. Opt. 23, 657-658 (1984) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
T-cell subpopulations in chronic lymphocytic leukemia: abnormalities in distribtuion and in in vitro receptor maturation (1979)

Purified human thymus-derived (T) lymphocytes were analyzed by detection of Fc receptors for either IgG or IgM in healthy controls and in patients with chronic lymphocytic leukemia (CLL). There was a significant and persistent increase in the numbers of T cells bearing receptors for IgG (Fc gamma) in CLL patients in comparison to the controls. After an in vitro culture period, there was a significantly decreased appearance of cells with IgM receptors (Fcmu) in CLL patients in comparison to the control group. These results indicate an imbalance in circulating T-cell subpopulations for CLL patients. In addition, an in vitro defect in CLL T-cell membrane receptor appearance is present.
Spatialized audioconferencing: what are the benefits? (2003)

Audioconference participants often have difficulty identifying the voices of other conferees, especially in ad hoc groups of unfamiliar members. Simultaneous presentation of multiple voices through a single, monaural channel can be discordant and difficult to comprehend. To address these shortcomings, we have developed the Vocal Village, a communications tool that allows for real-time spatialized audioconferencing across the Internet. The Vocal Village system uses binaural audio signals to present the voices of individual conference participants from different apparent positions in space by adding location cues to audio information.This paper describes our experimental research to determine whether the real-time, the head, spatialization cues implemented by Vocal Village are sufficient to provide performance benefits compared to traditional, monaural audio-conferencing methods. Performance benefits included memory, speaker identification, and participant preference. We also investigated whether providing users with the ability to control the location of conference participants within a virtual auditory space further enhanced any such benefits.The the head spatialization used in this experiment did not lead to a statistically significant increase in the ability to remember who said what in an audioconference. However, there was a borderline significant increase in remembering who said what when participants were given the opportunity to move the voices of two similar sounding conferees into different apparent locations. Participants also significantly preferred spatialized audio formats over the mono audio format. Spatialization had a significant effect on improving participants' perceived confidence in their memory of conferee viewpoints. Additionally, spatialization significantly reduced both the perceived difficulty of identifying speakers during conferences, as well as the amount of attention perceived to be dedicated to performing such voice identification. Providing subjects with the ability to control the apparent location of conference participants resulted in the greatest benefit to both of these measures.
Engine Inlet Anti-Icing System Evaluation Procedure (1980)

The objectives of this work were to develop a procedure for predicting and evaluating the performance of engine inlet anti-icing systems for compliance with FAR 25 ice protection requirements without conducting flight tests in natural icing conditions. This must include consideration of water droplet impingment, collection efficiency, internal and external heat transfer, and mass transfer of the impinging water. The method of approach for developing these procedures was to survey current analysis methods involving physical theory and empirical methods and then to develop a computerized model for use in anti-icing system performance analysis. Icing wind tunnel tests were conducted using a three-dimensional nacelle test model to aid in the procedure development. A typical engine-inlet anti-icing system was evaluated with the computer model in a variety of icing environments and operational conditions and compared with icing wind tunnel test results. Correlation between performance predictions and wind tunnel test results was found to have good agreement within the spectrum of conditions that were practicable in the wind tunnel. (Author)
Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles. (2015)

The amino acid profile of peptones may provide clues to identify the most effective feeding strategies for recombinant CHO cells.
Mitogen-activated protein kinase antisense oligonucleotide inhibits the growth of human lung cancer cells. (1999)

Mitogen-activated protein kinase (MAPK) pathway is proposed to be a therapeutic target for cancer cells. In order to find the potential therapeutic usefulness of MAPK for cancer cells, the effect of EAS1, an antisense oligonucleotide for an MAPK, on cancer-cell-growth were investigated in vitro. EAS1 effectively inhibited the growth of several human lung cancer cell lines such as PC-14 cells upon exposure to 10-0-10-1 microM of EAS1 determined dye-formation (MTT) assay. The ED50 values were comparable to those obtained for the inhibition of MAPK activity, DNA synthesis. EAS1 arrested the PC-14 cells at the G2/M phase of cell cycle followed by apoptosis in a dose-dependent manner. In order to determine the factors which influence the cellular sensitivity against MAPK inhibition, the effect of EAS1 on H-ras-transformed murine fibroblast cells were compared with that on parental cells. The NIH3T3 cells transformed by the H-ras gene (PT22-3) showed higher sensitivity against the effects of EAS1. Because MAPK activity was activated by H-ras gene transfection in PT22-3, the status of the MAPK cascade in cells was the determining factor for the efficacy of EAS1. In addition, cell permeabilization by digitonin enhanced the growth inhibitory effect of EAS1. Penetration of the cell membrane by EAS1 is also crucial for the growth inhibitory effect of EAS1. In conclusion, MAPK is an important target for cancer treatment and MAPK antisense oligonucleotide is a potentially significant antitumor oligonucleotide.
Excitation Functions of α-Particle Induced Nuclear Reactions on Highly Enriched <sup>92</sup>Mo: Comparative Evaluation of Production Routes for <sup>94m</sup>Tc (1995)

Article Excitation Functions of α-Particle Induced Nuclear Reactions on Highly Enriched 92Mo: Comparative Evaluation of Production Routes for 94mTc was published on January 1, 1995 in the journal Radiochimica Acta (volume 68, issue 1).
XML and quality objects (2003)

Adapting to desired and available QoS is key to the utility and dependability of distributed, Internet-centric applications including those based upon XML. In this paper we explore the possibility of transitioning QuO, which is a technology based on distributed objects for building and deploying QoS aware adaptive distributed systems, into XML based distributed systems.
False data injection attacks with incomplete information against smart power grids (2012)

False data injection attacks have recently been introduced as an important class of cyber attacks against smart grid's wide area measurement and monitoring systems. These attacks aim to compromise the readings of multiple power grid sensors and phasor measurement units in order to mislead the operation and control centers. Recent studies have shown that if an adversary has complete knowledge on the power grid topology and transmission-line admittance values, he can adjust the false data injection attack vector such that the attack remains undetected and successfully passes the residue-based bad data detection tests that are commonly used in power system state estimation. However, in this paper, we explain that a realistic false data injection attack is essentially an attack with incomplete information due to the attackers lack of real-time knowledge with respect to various grid parameters and attributes such as the position of circuit breaker switches and transformer tap changers and also because of the attacker's limited physical access to most grid facilities. We mathematically characterize false data injection attacks with incomplete information from both the attacker's and grid operator's viewpoints. Furthermore, we introduce a novel vulnerability measure that can compare and rank different power grid topologies against such attacks. To the best of our knowledge, this paper is the first study to investigate false data injection attacks with line admittance uncertainty.
Identification of Cultivar Differences in Seed Polypeptide Composition of Peanuts (<i>Arachis hypogaea</i> L.) by Two-Dimensional Polyacrylamide Gel Electrophoresis (1979)

Seed polypeptides from several cultivars of peanut (Arachis hypogaea L.) have been compared by means of a two-dimensional polyacrylamide gel electrophoresis. Protein was extracted from the defatted peanut meal by homogenizing in 5 millimolar K(2)CO(3)-9.5 molar urea. After addition of Nonidet P-40 (2%, v/v) and dithiothreitol (0.5%, w/v) the solution was centrifuged at 25,000 g. This procedure led to solubilization of more than 95% of the total protein. The clear supernatant fraction was then subjected to two-dimensional polyacrylamide gel electrophoresis, employing isoelectric focusing in the first dimension and electrophoresis in presence of sodium dodecyl sulfate in the second. After examining several cultivars, it was possible to construct a composite map to include all of the polypeptide species found among all of the cultivars examined. At least 74 major and between 100 and 125 minor components were detectable by Coomassie blue staining. The majority of these had isoelectric points between pH 4.4 and 8.0, and molecular weights between 16,000 and 75,000. Several different cultivars have been compared using this method and it has been shown that considerable variation exists among the major polypeptides present. The method should prove valuable for analyzing different genotypes and selecting varieties with a particular storage protein make-up, as well as for following compositional changes that occur during seed development and germination.
Toward Mending Two Nation-Scale Brokered Identification Systems (2015)

Abstract Available online public/governmental services requiring authentication by citizens have considerably expanded in recent years. This has hindered the usability and security associated with credential management by users and service providers. To address the problem, some countries have proposed nation-scale identification/authentication systems that intend to greatly reduce the burden of credential management, while seemingly offering desirable privacy benefits. In this paper we analyze two such systems: the Federal Cloud Credential Exchange (FCCX) in the United States and GOV.UK Verify in the United Kingdom, which altogether aim at serving more than a hundred million citizens. Both systems propose a brokered identification architecture, where an online central hub mediates user authentications between identity providers and service providers. We show that both FCCX and GOV.UK Verify suffer from serious privacy and security shortcomings, fail to comply with privacy-preserving guidelines they are meant to follow, and may actually degrade user privacy. Notably, the hub can link interactions of the same user across different service providers and has visibility over private identifiable information of citizens. In case of malicious compromise it is also able to undetectably impersonate users. Within the structural design constraints placed on these nation-scale brokered identification systems, we propose feasible technical solutions to the privacy and security issues we identified. We conclude with a strong recommendation that FCCX and GOV.UK Verify be subject to a more in-depth technical and public review, based on a defined and comprehensive threat model, and adopt adequate structural adjustments.