gebhart/patrepeval huggingface dataset:
A Wide-Range On-Chip Leakage Sensor Using a Current–Frequency Converting Technique in 65-nm Technology Node (2015)

As technology moves toward the submicrometer regime, leakage current due to aggressive scaling and parameter variation has become a major problem in high-performance integrated circuit designs. Therefore, accurate measurement of the leakage current flowing through transistors has become a critical task for better understanding of process and design. In this brief, we propose a simple on-chip circuit technique for measuring a wide-range static standby (or leakage) current in a 65-nm technology with high accuracy. The circuit consists of a current amplifier, a bias stabilizer, and a voltage-controlled oscillator. The proposed leakage sensor is designed to measure leakage currents from 20 pA to 20 nA. Simulation results show that the proposed sensor has less than 8.4% error over a wide range of leakage currents (i.e., three orders of magnitude). Chip measurement results also indicate that the proposed leakage sensor is operating properly and measures the standby leakage current values of the devices under test within the possible range at different temperatures. The power consumption of the proposed leakage sensor was 0.6 mW when the leakage current was 1 nA, and the active area was 0.007 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Cine magnetic resonance imaging for evaluation of anatomy and flow relations in infants and children with coarctation of the aorta. (1988)

Sixteen cine magnetic resonance imaging (MRI) studies were performed in 14 patients aged 1 week to 17 years (mean age, 46 months), who had coarctation of the aorta confirmed at angiography or surgery. Conventional echocardiographic-gated MRI was first performed in axial and rotated sagittal views and was used to identify the slice locations for cine MRI. Cine MRI was performed by gradient-recalled acquisition in steady state with a 30 degree flip angle, 12-msec echo time, 22-msec pulse repetition time, and a 128 x 256 acquisition matrix. Coarctation anatomy was extremely well defined in all but one patient who had vascular clips at the coarctation repair site. The smallest descending aortic flow diameter on cine MRI showed excellent agreement with angiography (r = 0.90). Lucent jets of high-velocity flow through the site of coarctation were imaged in eight patients, and jet length correlated well with the angiographic severity of coarctation (r = -0.81). Two patients were restudied after surgery, and they exhibited excellent repair and normal flow patterns. Cine MRI provides high-resolution imaging of coarctation anatomy with a dynamic spatial and temporal visualization of flow and with excellent detail of vascular anatomy and flow both proximal and distal to the coarctation.
Subcritical Water Regeneration of Supported Ruthenium Catalyst Poisoned by Sulfur (2008)

A titania-supported ruthenium (Ru/TiO2) catalyst was effective for the gasification of lignin to methane, carbon dioxide, and hydrogen in supercritical water. For the Ru/TiO2 catalyst poisoned by sulfur (S−Ru/TiO2), the overall gas yield decreased and the tetrahydrofuran-insoluble products (namely, char) were slightly formed in supercritical water gasification. After subcritical water treatments of the S−Ru/TiO2 catalyst at 523 and 573 K, its gasification activity was found to be higher than that without the treatment. On the other hand, the treatment of the S−Ru/TiO2 catalyst in supercritical water at 673 K showed lower activity than that in subcritical water. X-ray photoelectron spectroscopy analysis showed that three-fourths of the amount of sulfur was removed from the catalyst surface after the subcritical water treatment. It was concluded that deactivated catalysts poisoned by sulfur species could be regenerated by the removal of the sulfur by the treatment with subcritical water.
EphA3 biology and cancer (2014)

Eph receptor tyrosine kinases control cell-cell interactions during normal and oncogenic development, and are implicated in a range of processes including angiogenesis, stem cell maintenance and metastasis. They are thus of great interest as targets for cancer therapy. EphA3, originally isolated from leukemic and melanoma cells, is presently one of the most promising therapeutic targets, with multiple tumor-promoting roles in a variety of cancer types. This review focuses on EphA3, its functions in controlling cellular behavior, both in normal and pathological development, and most particularly in cancer.
ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal. (2005)

One of the major problems related with anticancer chemotherapy is resistance against anticancer drugs. The ATP-binding cassette (ABC) transporters are a family of transporter proteins that are responsible for drug resistance and a low bioavailability of drugs by pumping a variety of drugs out cells at the expense of ATP hydrolysis. One strategy for reversal of the resistance of tumor cells expressing ABC transporters is combined use of anticancer drugs with chemosensitizers. In this review, the physiological functions and structures of ABC transporters, and the development of chemosensitizers are described focusing on well-known proteins including P-glycoprotein, multidrug resistance associated protein, and breast cancer resistance protein.
Frequency and typing of Propionibacterium acnes in prostate tissue obtained from men with and without prostate cancer (2016)

The present study provides further evidence for a role of P. acnes in prostate cancer development.
Some Objective Considerations for the Neutralization of the Anticoagulant Actions of Recombinant Hirudin (1991)

Recombinant hirudin (r-hirudin) is currently under development as an anticoagulant for use in surgery, therapeutic anticoagulation, disseminated intravascular coagulation and other pathologic states involving the generation of thrombin. Circulating levels of r-hirudin as an antithrombotic agent range from 2 to 20 micrograms/ml (0.1-1.0 mg/kg) as determined in an animal model of stasis thrombosis. In order to establish a relationship between the r-hirudin circulating level and bleeding, we utilized a rabbit ear blood loss model. r-Hirudin did not produce any loss of blood at dosages up to 20 micrograms/ml i.v. (1.0 mg/kg). When the circulating levels were maintained at 20 micrograms/ml for periods of up to 3 h, no increase in blood loss was observed. At 50 and 100 micrograms/ml initial circulating levels (2.5 and 5.0 mg/kg) a dose-dependent increase in the blood loss was observed which was equivalent to that observed with 1.25 and 2.5 mg/kg i.v. heparin. Such levels of r-hirudin are not expected in clinical usage. In contrast to heparin, the anticoagulant actions of r-hirudin were not neutralized by protamine sulfate, platelet factor 4, other polycationic agents and heparinase. In our studies, the blood loss induced by greater than 2.0 mg/kg i.v. dosages of r-hirudin in an animal model was neutralized by the administration of an activated prothrombin complex concentrate at 25 U/kg. In a similar experimental setting, r-factor VIIa was also partially effective. These studies suggest that r-hirudin anticoagulation may not require neutralization, since bleeding effects are not observed at effective antithrombotic dosages in individuals with normal hemostatic status.(ABSTRACT TRUNCATED AT 250 WORDS)
The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread (2016)

Individual variability has clear effects upon the outcome of therapies and treatment approaches. The customization of healthcare options to the individual patient should accordingly improve treatment results. We propose a novel approach to brain interventions based on personalized brain network models derived from non-invasive structural data of individual patients. Along the example of a patient with bitemporal epilepsy, we show step by step how to develop a Virtual Epileptic Patient (VEP) brain model and integrate patient-specific information such as brain connectivity, epileptogenic zone and MRI lesions. Using high-performance computing, we systematically carry out parameter space explorations, fit and validate the brain model against the patient's empirical stereotactic EEG (SEEG) data and demonstrate how to develop novel personalized strategies towards therapy and intervention.
JPEG2000 for Digital Cinema (2006)

JPEG2000 is the latest international standard for image compression. The rich feature set and the state of the art image compression performance make JPEG2000 an attractive alternative for many applications. One of the latest applications to utilize JPEG2000 is digital cinema. Digital Cinema Initiatives (DCI) is a joint venture of seven major Hollywood studios. DCI was formed to establish specifications for an open architecture for digital cinema. As part of these specifications, DCI has selected JPEG2000 for future distribution of motion pictures. In this paper, we provide a brief overview of the DCI specification and discuss how JPEG2000 is utilized within this specification
Dielectric volume measurements for biomedical applications (2009)

We have developed a dielectric measurement system for recovering the properties of bulk tissue samples utilizing a specialized configuration of our microwave tomographic imaging system. We exploit the fact that the sample's location, shape and size can be determined a priori based on the known fixture geometry and integrate this with a soft prior algorithm to essentially recover a single dielectric property within the target zone. This is potentially an important approach for cases where the widely applied coaxial probe approach is not optimal due to poor surface contact and property differences between the surface and tissue interior. For example, the treated surface of a sample of cancellous bone can be quite heterogeneous given the intricate web of trabeculae, fat and marrow. Our technique is able to reconstruct a value for this sample which is indicative of the whole volume.
Effect of 12‐week dulaglutide therapy in Japanese patients with biopsy‐proven non‐alcoholic fatty liver disease and type 2 diabetes mellitus (2016)

Dulaglutide, a new glucagon-like peptidase-1 receptor agonist, could be a novel promising agent for the treatment for NAFLD patients with T2DM due to its efficacy in body weight reduction, the nature of weekly injection, and patient preference. Prospective randomized controlled trials are warranted to confirm this impact of dulaglutide on NAFLD with T2DM.
Cheap, Fast and Good Enough: Automatic Speech Recognition with Non-Expert Transcription (2010)

Deploying an automatic speech recognition system with reasonable performance requires expensive and time-consuming in-domain transcription. Previous work demonstrated that non-professional annotation through Amazon’s Mechanical Turk can match professional quality. We use Mechanical Turk to transcribe conversational speech for as little as one thirtieth the cost of professional transcription. The higher disagreement of non-professional transcribers does not have a significant effect on system performance. While previous work demonstrated that redundant transcription can improve data quality, we found that resources are better spent collecting more data. Finally, we describe a quality control method without needing professional transcription. 1
Key Note Lecture (2007)

Constructing a mechanistic taxonomy of all forms of pcd--based on inhibitors, activators, and identified biochemical pathways involved in each form of pcd--should offer new insight into cell deaths associated with cerebrovascular disease and other diseases, and ultimately offer new therapeutic approaches.
Preliminary Evaluation of a Turbine/Rotary Combustion Compound Engine for a Subsonic Transport (1976)

The fuel consumption of a modern compound engine with that of an advanced high pressure ratio turbofan was compared. The compound engine was derived from a turbofan engine by replacing the combustor with a rotary combustion (RC) engine. A number of boost pressure ratios and compression ratios were examined. Cooling of the RC engine was accomplished by heat exchanging to the fan duct. Performance was estimated with an Otto-cycle for two levels of energy lost to cooling. The effects of added complexity on cost and maintainability were not examined and the comparison was solely in terms of cruise performance and weight. Assuming a 25 percent Otto-cycle cooling loss (representative of current experience), the best compound engine gave a 1.2 percent improvement in cruise. Engine weight increased by 23 percent. For a 10 percent Otto-cycle cooling loss (representing advanced insulation/high temperature materials technology), a compound engine with a boost PR of 10 and a compression ratio of 10 gave an 8.1 percent lower cruise than the reference turbofan.
Simultaneous multithreading fault tolerance processor (2005)

Transient fault detection mechanism is added to simultaneous multithreading architecture. By exploiting both ILP (Instruction Level Parallelism) and TLP (Thread Level Parallelism), Simultaneous Multithreading (SMT) Fault Tolerance Processor can be expected to achieve better tradeoff between performance and hardware cost than traditional Fault Tolerance Processors. Detailed simulations of 3 of SPEC95 benchmarks show that executing two redundant programs on the fault-tolerant microarchitecture takes only 40%–61% longer than running a single version of the program. The new instruction fetch algorithm enhances the performance by 0.4% ∼1% to most of the benchmarks we choose randomly.
Flower image segmentation based on color analysis and a supervised evaluation (2012)

We propose a flower segmentation schema which overcomes some limits of previous works. Indeed, it does not involve any interaction with the user, or make assumptions based on the domain knowledge. To achieve segmentation, we used OTSU thresholding on Lab color space. The thresholding was performed, separately, on the three component L, a and b, and the best result is selected relatively to the ground truth. The experimentation of the proposed method, performed using the dataset from the Oxford flower collection, make better the results, while consuming less CPU time, than the method proposed by Nilsback and Zisserman[5].
A Family of Simplified Geometric Distortion Models for Camera Calibration (2003)

The commonly used radial distortion model for camera calibration is in fact an assumption or a restriction. In practice, camera distortion could happen in a general geometrical manner that is not limited to the radial sense. This paper proposes a simplified geometrical distortion modeling method by using two different radial distortion functions in the two image axes. A family of simplified geometric distortion models is proposed, which are either simple polynomials or the rational functions of polynomials. Analytical geometric undistortion is possible using two of the distortion functions discussed in this paper and their performance can be improved by applying a piecewise fitting idea. Our experimental results show that the geometrical distortion models always perform better than their radial distortion counterparts. Furthermore, the proposed geometric modeling method is more appropriate for cameras whose distortion is not perfectly radially symmetric around the center of distortion.
Abstract 340: Myosin Regulatory Light Chain: A Major Player in Defining the ‘OFF’ State of Cardiac Myosin (2019)

Myosin regulatory light chain (RLC) is a regulatory subunit of the myosin molecule, which plays a major role in stabilizing the Interacting Head Motif (IHM) of myosin in non-striated muscle. However, in striated muscle, its purpose is less well defined, and it is only in the past decade that researchers have started unraveling the function of RLC and its phosphorylation in muscle contraction. In this study, we report the role of human cardiac RLC in forming the Super-Relaxed State (SRX) of myosin in reconstituted full-length cardiac myosin thick filaments and show that removal of RLC destabilizes the ability of myosin to form the SRX state. Phosphorylation of the RLC with MLCK has the same effect, which renders the myosin to the ‘OFF’ state as confirmed by its ATPase activity. Interestingly we found that Ca 2+ and not Mg 2+ binding to synthetic myosin filaments had differential effects on the population of the myosin SRX state. At systolic Ca 2+ myosin exhibits lower SRX state than at diastolic Ca 2+ . This effect is obliterated in RLC-lacking myosin constructs such as sS1, or RLC stripped myosin filaments suggesting that Ca 2+ binding to RLC can activate the myosin from the ‘OFF’ state to a more active state. Naturally occurring cardiomyopathy-causing RLC mutants R58Q, K104E and D94A did not alter this property, but two of them, K104E and D94A abolished the phosphorylation regulation of the SRX state of myosin. Altogether, these observations demonstrate that either RLC phosphorylation or binding of systolic Ca 2+ can reduce the number of accessible myosin heads for contraction and could form the basis of the Ca 2+ -mediated activation of the sarcomeric thick filament and mutations in RLC can alter these abilities differentially.
RNA aptamers to a protease, subtilisin. (1997)

RNA ligands (RNA aptamers) to a protease subtilisin were selected from pools of random RNA using SELEX (Systematic evolution of ligands by exponential enrichment). We selected RNA aptamers using a subtilisin-immobilized Sepharose column. After several rounds of selection, we obtained RNA aptamers that specifically inhibit the subtilisin activity. Characterization of the RNA aptamers will be reported.
On classes of rate k/(k+1) convolutional codes and their decoding techniques (1996)

For the class of rate k/(k+1) convolutional codes, Yamada et al. (1983) proposed an efficient maximum-likelihood decoding algorithm called the YHM algorithm. In order to reduce the complexity of the YHM algorithm, this paper presents two techniques for simplifying the trellis diagram used in the YHM algorithm. We further observe that the proposed techniques effectively reduce the complexity of the YHM algorithm for two classes /spl Xi/ and /spl Xi//sub f/ (which is a subclass of /spl Xi/) of rate k/(k+1) convolutional codes. The construction of codes in these classes is also discussed. It is shown that /spl Xi/ codes with d/sub free/=3,4 can be obtained by simple construction. A code search algorithm for /spl Xi/ codes with d/sub free//spl ges/5 is also introduced. Computer searches are performed to construct good /spl Xi/ and /spl Xi//sub f/ codes. For specified decoding complexities, a number of these new codes give better error performance than previously reported codes.
Sustained cannabinoid agonist treatment augments CGRP release in a PKA-dependent manner (2009)

Studies have shown that sustained cannabinoid treatment increases the sensitivity to painful heat stimuli (thermal hyperalgesia) and innocuous mechanical stimuli (tactile allodynia). It has been suggested that augmented release of pain neurotransmitters (such as calcitonin gene-related peptide, CGRP) might be responsible for this abnormal pain sensitization. We hypothesize that intracellular adaptations upon sustained cannabinoid treatment causes augmented release of CGRP from primary nociceptors leading to increased pain sensitivity. We show that sustained (24 h) cannabinoid agonist [(+)WIN 55,212-2] treatment of 7-day-old neonatal rat dorsal root ganglion neurons significantly augments basal CGRP release from these cells in a protein kinase A-dependent manner. Our results indicate that these intracellular compensatory adaptations may play a crucial trigger role in further neuronal system adaptations for modulation of pain.
ChemInform Abstract: STUDIES ON MIXED CYCLIC ACETALS. XVIII. REACTIONS OF GLYOXAL WITH AMINO ALCOHOLS (1978)

Abstract Die Reaktion von Glyoxal (I) mit den N‐Alkyl‐aminoethanolen (II) führt nicht zu den erwarteten 2‐Formyl‐N‐alkyl‐oxazolidinen, sondern zu den Bioxazolidinylen (III) und den Nebenprodukten (IV)‐(VI).
Mitochondria and peroxisomes: Are the ‘Big Brother’ and the ‘Little Sister’ closer than assumed? (2007)

Mitochondria and peroxisomes are essential subcellular organelles in mammals. Despite obvious differences, both organelles display certain morphological and functional similarities. Recent studies have elucidated that these highly dynamic and plastic organelles share components of their division machinery. Mitochondria and peroxisomes are metabolically linked organelles, which are cooperating and cross-talking. This review addresses the dynamics and division of mitochondria and peroxisomes as well as their functional similarities to provide insight as to why these organelles share the fission machinery in evolutionary aspects.
Gesture-Based Image Acquisition between Smartphone and Digital Signage (2011)

Mobile phones have formed a social network within the phone subscriber population by allowing the phone subscribers to exchange information. Nowadays, smartphones have been improved with a variety of functionalities, such as a built-in cameras, motion sensors, and Wi-Fi wireless connectivity to enable the phone subscriber to take photographs of a desired object for distribution to other users through SMS or email. These functionalities make the mobile phones the perfect tool in terms of viral marketing within cellular phone subscribers.\n\nThis thesis proposes a novel methodology that allows the phone subscriber to perform gestures for image acquisition from public signage displays. The public display is signage which displays a list of images in chronological order. The signage distributes the image list to nearby phones in the form of datagrams by means of multi-casts. Additionally, Wi-Fi connection between the phone and the\nsignage must be established to enable multi-cast. When the phone has the completed image list\ndownloaded, the phone subscriber can point the phone at the signage and perform a dragging gesture once he sees the desired image displayed by the signage. The current state of the project has concluded the development of the application to achieve the aforementioned task. However, the development of data transmission from one phone to another is still ongoing. Further development in the future would enable another gesture for data distribution to other phones in the vicinity.\n\nWeb-based administration applications have also been developed to manage the image list in the\nsignage. Through this web-based application, the administrator can generate new image list and then upload it to a FTP server. When the updated image list is stored in a remote FTP server, the signage periodically retrieves the image list from the FTP server. After the signage has received the updated image list, it then distributes the image list in the form of datagrams by means of multicasts. In summary, this thesis documents the impact of such technology in viral marketing research.
Antiopes toxicologie prédictive - approche systémique - environnement santé (2009)

National audience