gebhart/patrepeval huggingface dataset:
A coagulation pathway on bovine aortic segments leading to generation of Factor Xa and thrombin. (1984)

Previous studies have demonstrated the binding of Factors IX and IXa to cultured bovine aortic endothelial cells. The present study examines the interaction of Factors IX, IXa, and Xa with the luminal surface of calf aortas, shown by microscopic examination to have a continuous layer of endothelium. Radioimmunoassay of Factor IX showed that 74 fmol/10(6) cells of Factor IX could be eluted from freshly prepared aortic segments. Binding of 3H-Factors IX and IXa to aortic segments was saturable, and comparable to binding in previous studies using cultured endothelial cells. Preincubation of aortic segments with 3H-Factor IXa and von Willebrand factor (VWF)/Factor VIII, followed by washing and addition of Factor X, resulted in formation of Factor Xa. The addition of prothrombin to these activation mixtures resulted in formation of thrombin. Exogenous phospholipid and Factor V were not required for Factor X and prothrombin activation on the intact native endothelium. Incubation of 125I-Factor Xa with the vessel segments resulted in most of the tracer being complexed with antithrombin III originally present on the aortic segment (3.8 pmol antithrombin III/10(6) cells). The Factor Xa-antithrombin III complex was observed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis exclusively in the supernatants. 125I-Factor Xa not complexed with antithrombin III bound specifically to the vessel segment. The time course of binding was biphasic, consisting of an initial more rapid reversible phase followed by a slower irreversible phase. The latter phase correlated with the formation of a covalent complex (Mr, 76,000) between 125I-Factor Xa and a vessel-localized protein presumably distinct from antithrombin III. The activation of prothrombin by vessel-bound Factor Xa was inhibited by anti-bovine Factor V IgG, suggesting that there is interaction of Factor Xa with a Factor V-like molecule provided by the endothelial cell surface. Addition of antibody to antithrombin III prevented formation of Factor Xa-antithrombin III and thrombin-antithrombin III complexes in the supernatant and increased apparent thrombin activity 30-50-fold. These studies demonstrate that freshly obtained vessels with a continuous layer of native endothelium can support activation of Factor X and prothrombin: vessel-bound Factor IXa can activate Factor X in the presence of VWF/Factor VIII. Factor Xa can also bind to the vessel and participate in the activation of prothrombin. The apparent efficiency of prothrombin activation, however, is dampened by the presence of functional antithrombin III on the vessel wall.
Curbing the roofline (2016)

Convolutional Neural Networks (CNNs) have reached outstanding results in several complex visual recognition tasks, such as classification and scene parsing. CNNs are composed of multiple filtering layers that perform 2D convolutions over input images. The intrinsic parallelism in such a computation kernel makes it suitable to be effectively accelerated on parallel hardware. In this paper we propose a highly flexible and scalable architectural template for acceleration of CNNs on FPGA devices, based on the cooperation between a set of software cores and a parallel convolution engine that communicate via a tightly coupled L1 shared scratchpad. Our accelerator structure, tested on a Xilinx Zynq XC-Z7045 device, delivers peak performance up to 80 GMAC/s, corresponding to 100 MMAC/s for each DSP slice in the programmable fabric. Thanks to the flexible architecture, convolution operations can be scheduled in order to reduce input/output bandwidth down to 8 bytes per cycle without degrading the performance of the accelerator in most of the meaningful use-cases.
Studies on the quantification of specific cyanogens in cassava products and introduction of a new chromogen (1993)

Abstract The enzymic assay for cyanogens in cassava as developed by Cooke (1978) and improved by O'Brien et al (1991), was compared with a standard method, involving autolysis/steam distillation/titration, and further improved with a more acceptable coloration and other minor changes. Cooke's assay, using a linamarin calibration curve, gave similar values for cyanogenic potential in fresh cassava as the standard method. For cassava samples with high non‐glycosidic cyanogen levels, Cooke's assay yielded slightly lower values. Isonicotinate/1,3‐dimethyl barbiturate as reagent in the König reaction had the following advantages compared with the so far applied pyridine/pyrazolone color reagent. It is less toxic and does not release repulsive vapours. It is faster, cheaper and easier to handle, and has increased sensitivity and longer storability. Direct measurement of cyanogenic potential was accurate in extracts containing 35–700 μM. Recovery of linamarin supplements was 102±4%. Separate calibration curves of linamarin, acetone cyanohydrin and KCN were necessary for accurate calculation of cyanogenic glycosides and cyanohydrin levels. Extract storability depended slightly on storage temperature, but was not changed by inclusion of ethanol in the extract medium.
Cross-flow filtration in physical-chemical treatment of municipal sewage effluents (1976)

In separations of solids from liquids by filtration, the motion of liquid is customarily normal to the filtering surface, and solids are left on the filter. In a variation called cross-flow filtration, liquid is pumped parallel to the filtering surface. By this device, thickening of flux-limiting filtercake is slowed, and the original stream is separated into a large volume of filtrate and a concentrated slurry of solids. Results reported here were obtained in cross-flow filtration used as an element in physical-chemical treatment of municipal sewage, mostly with the effluent from primary settling, but in some cases, with clarified activated sludge effluent as feed. Filtrate from passage through fabric tubes (1-inch fire-hose jackets) of primary effluent, treated with iron or aluminum salts, with powdered activated carbon (PAC), or with both hydrolyzable ions and PAC, was generally of quality superior in turbidity, organic carbon and other respects to the effluent from biological secondary treatment. Effects on product quality and flux of pressure, circulation velocity, additive concentration, water recovery, pH and other variables were investigated. Based on production rates obtained, estimates of treatment costs were made.
Development of an Inlet Pressure Sensor for Control in a Left Ventricular Assist Device (2010)

A Tesla type continuous flow left ventricular assist device (VAD) has been designed by Penn State and Advanced Bionics, Inc. (ABI). When a continuous flow device is used, care must be taken to limit low pressures in the ventricle, which can produce an obstruction to the inlet cannula or trigger arrhythmias. Design of an inexpensive, semiconductor strain gauge inlet pressure sensor to detect suction has been completed. The research and design analysis included finite element modeling of the sensing region. Sensitivity, step-response, temperature dependence, and hysteresis tests have been performed on prototype units. All sensors were able to withstand the maximum expected strain of 82 microm/in at 500 mm Hg internal pressure. Average sensitivity was 0.52 +/- 0.24 microV/mm Hg with 0.5 V excitation (n = 5 units). Step-response time for a 0- to 90-mm Hg step change averaged 22 msec. Hysteresis was measured by applying and holding 75 mm Hg internal pressure for 4 hours, followed by a zero pressure measurement, and ranged from -15 to 4.1 mm Hg (n = 3 units). Offset drift varied between 180 and -140 mm Hg over a 4-week period (n = 2 units). Span temperature sensitivity ranged from 18 to -21 muV/ degrees C (n = 5 units). Gain temperature sensitivity ranged from -7.4 to 4.9 muV/ degrees C (n = 5 units). With the inherent drift, it is currently not possible to use the transducer to measure actual pressures, but it can easily be used to measure pressure changes throughout the cardiac cycle. This signal can then be used in the control system to avoid ventricular suction events.
3D global tomographic velocity model building (2004)

Accurate subsurface velocity estimation is crucial in seismic exploration, especially for prestack depth migration, depth conversion, geopressure prediction and AVO attribute computation. 3D reflection tomography is the most accurate method available for velocity estimation. The challenge that we face is in designing an accurate tomographic system capable of efficiently handling large volumes of seismic data acquired over increasingly complex targets. To address this need we have developed a 3D reflection tomography system using a tetrahedra‐based model parameterization. Tetrahedra are capable of accurately representing complex velocity models with far fewer control points compared with other methods. The input for our tomography comes from automatically scanned migration residuals and structural dips generated from Kirchhoff prestack depth migration. An adaptive layer‐based method is employed with flexible geological constraints, which enables global tomographic inversion of both compaction and competent geological environments. Application of global tomography to synthetic data demonstrates its ability to resolve strong and rapid velocity variations. Examples from 3D field data are shown to illustrate the benefits of this global tomographic system in estimating velocity models for large‐scale prestack depth migration projects.
Strategies to prevent nephrotoxicity of anticancer drugs (1995)

Nephrotoxicity is a relatively common and potentially serious adverse effect of treatment with certain cytotoxic drugs (especially ifosfamide). The patient may develop severe chronic proximal tubular toxicity. It is therefore very important to attempt to reduce the frequency and severity of acute and chronic nephrotoxicity resulting from chemotherapy. A logical approach is described, with particular reference to ifosfamide and cisplatin, involving improved evaluation of the important clinical features of nephrotoxicity and a greater understanding of its pathogenesis. This approach will facilitate the development of logical preventive strategies, or less toxic analogues, or both. The methods used may also enable prediction of the potential nephrotoxicity of newly developed cytotoxic agents.
Constellation labeling for linear encoders (2001)

This paper investigates optimal constellation labeling in the context of the edge profile. A constellation's edge profile lists the minimum-distance edge for each binary symbol error. The paper introduces the symmetric-ultracomposite (SU) labeling structure and shows that this structure provides undominated edge profiles for 2/sup n/-PSK, 2/sup n/-PAM, and 2/sup 2n/-point square QAM. The SU structure is a generalization of the commonly used reflected binary Gray code. With the proper choice of basis vectors, SU labeling can support either set-partition or Gray-code labeling of 2/sup n/-PSK, 2/sup n/-PAM, and 2/sup 2n/-point square QAM. Notably, there are Gray-code and set-partition labelings that do not have the SU structure. These labelings yield inferior edge profiles. The SU structure does not apply to cross constellations. However, for any standard cross constellation with 32 or more points, a quasi-SU labeling structure can approximate the SU structure. With the correct choice of basis, quasi-SU labelings produce quasi-Gray labelings. However, the quasi-SU structure cannot support set-partition labeling. In fact, the quasi-SU structure provides a better edge profile than standard set-partition labeling. Thus, for cross constellations there is a choice between edge profile optimality and the group structure provided by set-partitioning. Here, the correct choice depends on whether the encoder trellis has parallel branches.
Micromachined millimeter-wave photonic band-gap crystals (1994)

We have developed a new technique for fabricating three-dimensional photonic band-gap crystals. Our method utilizes an orderly stacking of micromachined (110) silicon wafers to build the periodic structure. A structure with a full three-dimensional photonic band gap centered near 100 GHz was measured, with experimental results in good agreement with theoretical predictions. This basic approach described should be extendable to build structures with photonic band-gap frequencies ranging from 30 GHz to 3 THz.
Alzheimer Disease -- A Spirochetosis? (1994)

The aetiology of Alzheimer's disease (AD), which affects a large proportion of the aged population is unknown and the treatment unresolved. The role of beta amyloid protein (beta A4), derived from a larger amyloid precursor protein (APP) in AD is the subject of intense research. Here I report observations that in 14 autopsy cases with histopathologically confirmed AD, spirochetes were found in blood and cerebrospinal fluid and, moreover, could be isolated from brain tissue. Thirteen age-matched control cases were without spirochetes. Reference strains of spirochetes and those isolated from brains of AD patients, showed positive immunoreaction with monoclonal antibody against the beta amyloid precursor protein. These observations suggest that spirochetes may be one of the causes of AD and that they may be the source of the beta amyloid deposited in the AD brain.
The Cell Biology of Synaptic Plasticity: AMPA Receptor Trafficking (2007)

The cellular processes that govern neuronal function are highly complex, with many basic cell biological pathways uniquely adapted to perform the elaborate information processing achieved by the brain. This is particularly evident in the trafficking and regulation of membrane proteins to and from synapses, which can be a long distance away from the cell body and number in the thousands. The regulation of neurotransmitter receptors, such as the AMPA-type glutamate receptors (AMPARs), the major excitatory neurotransmitter receptors in the brain, is a crucial mechanism for the modulation of synaptic transmission. The levels of AMPARs at synapses are very dynamic, and it is these plastic changes in synaptic function that are thought to underlie information storage in the brain. Thus, understanding the cellular machinery that controls AMPAR trafficking will be critical for understanding the cellular basis of behavior as well as many neurological diseases. Here we describe the life cycle of AMPARs, from their biogenesis, through their journey to the synapse, and ultimately through their demise, and discuss how the modulation of this process is essential for brain function.
Transmission line models for negative refractive index media and associated implementations without excess resonators (2003)

Recently, three-dimensional composite periodic media comprising split-ring resonators (SRR) and thin wires have been shown to exhibit a negative refractive index in the frequency range around the SRR resonance. In this letter, we propose transmission line models for studying and interpreting the electromagnetic propagation behavior of such materials. Based on these equivalent transmission line models, we show that by periodically loading a network of transmission lines with series capacitors and shunt inductors, a negative refractive index medium can be synthesized without excess resonators, thus leading to wideband behavior. These proposed media have tailorable properties over a broad frequency range. Moreover, they are completely planar, frequency scalable, more compact, and easier to implement for RF/microwave circuit applications than their SRR/wire counterparts.
A Framework for the Real-Time Walkthrough of Massive Models (1998)

We present a framework for rendering very large 3D models at nearly interactive rates. The framework scales with model size. Our framework can integrate multiple rendering acceleration techniques, including visibility culling, geometric levels of detail, and image-based approaches. We describe the database representation scheme for massive models used by the framework. We provide an effective pipeline to manage the allocation of system resources among different techniques. We demonstrate the system on a model of a coal-fired power plant composed of more than 15 million triangles. CR Categories and Subject Headings: H.2 -- Database Management, I.3.3 -- Picture/Image Generation (Display Algorithms), I.3.4 -- Graphics Utilities (Application packages), I.3.6 -- Methodology and Techniques (Graphics data structures), I.3.7 -- Three-Dimensional Graphics and Realism (Virtual reality), J.2 -- Physical Sciences and Engineering (Engineering), J.6 -- Computer-Aided Engineering (Computer-aided des...
Low Cost Zinc Sulfide Missile Dome Manufacturing (2008)

Abstract : In conclusion, the new Army ManTech Program Low Cost Zinc Sulfide Missile Dome is currently addressing advanced manufacturing methods for lower unit production cost of multispectral zinc sulfide domes. While Dome Program personnel are still working out some of the details of the program, the objectives and planned improvements have been provided along with a program schedule and potential transitions to current DoD programs. The recent emphasis on development of affordable tri-mode seeker technologies has also been discussed. The AMRDEC Affordability and Manufacturing Engineering Team anticipates great successes on this program, and plans to take every opportunity to present these successes to achieve the widest possible dissemination to the DoD community.
Epoxy systems with improved water resistance, and the non‐fickian behaviour of epoxy systems during water ageing (1983)

Abstract N,N ‐Bis (2, 3‐epoxypropyl) aniline and 4,4′‐methylenebis‐[ N,N ‐bis (2,3‐epoxypropyl) aniline] containing bromo, chloro, trifluoromethyl or polyfluoroalkoxy substituents were synthesised and cured with aromatic diamines in order to investigate the effect of substituted halogen on water absorption. Significant improvements were achieved: thus use of 4,4′‐methylenebis‐[ N, N ‐bis (2, 3‐epoxypropyl)‐3, 5‐dichloroaniline] and 4,4′‐methylenebis‐[ N,N ‐bis (2,3‐epoxypropyl)‐3‐(trifluoromethyl) aniline] instead of 4,4′‐methylenebis‐[ N,N ‐bis (2,3‐epoxypropyl) aniline] reduced the water absorption by about a half. Departures from Fickian behaviour were observed during water immersion ageing at room temperature and were a general feature of the epoxy systems examined. Plots of water absorption against the Fickian parameter (√ t / d ) usually showed at least mild sigmoid character and were not independent of specimen thickness. Further, slow continued uptake of water occurred during long‐term ageing, and evidence is provided that the associated network distortions are reversible.
Stereospecific Alkyne Reduction: Novel Activity of Old Yellow Enzymes (2007)

Old enzyme, new trick: An environmentally sustainable alternative for the regio- and stereoselective reduction of the alkyne bond is the biotransformation by “Old Yellow Enzyme” (OYE). This “old” enzyme, first isolated in 1932, catalyzes the trans-selective hydrogenation of the carbon–carbon triple bond under mild conditions.
Apple, Broad-Spectrum Insect Control, 1992 (1993)

Abstract Insecticides were applied to mature trees in Douglas, MI (‘B’ Block) at a rate of 150 gal/acre with an FMC CP 3000 sprayer. Treatments were arranged as completely randomized units consisting of single trees replicated 4 times. Applications were made, as indicated, on 30 Apr (1/2 Green), 5 May (tight cluster), 12 May (pink), 28 May (petal fall), 9 Jun (1C), 22 Jun (2C), 2 Jul (3C), 15 Jul (4C), 27 Jul (5C), 7 Aug (6C), 20 Aug (7C), and 1 Sep (8C). Streptomycin, Dithane, Captan, and Nova were applied separately to all treatments. Mid-season fruit finish was evaluated on 26 Jun, by picking 50 apples per replicate (100 apples per treatment). Harvest fruit finish data were taken on 9 Sep from 100 fruit taken randomly from the periphery of the tree from each replicate, for a total of 400 fruit per treatment.
Improving genetic classifiers with a boosting algorithm (2004)

We present a boosting genetic algorithm for classification rule discovery. The method is based on the iterative rule learning approach to genetic classifiers. The boosting mechanism increases the weight of those training instances that are not classified correctly by the new rules, so that in the next iteration the algorithm focuses the search on those rules that capture the misclassified or uncovered instances. We show that the boosted genetic classifier has higher accuracy for prediction, or from an alternative and perhaps more important perspective, uses less computational resources for similar accuracy, than the original genetic classifier.
MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1 (2011)

MicroRNAs (miRNAs) are emerging as important modulators in cellular pathways and they appear to play a key role in tumorigenesis. MiR-145 is downregulated in several human malignancies, including lung cancer, but the responsible molecular mechanisms remain unclear. We previously reported that restoration of hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) mutation. This study showed that hsa-miR-145 targets EGFR and nucleoside diphosphate linked moiety X-type motif 1 (NUDT1 or MTH1) in lung adenocarinoma cells. The mRNA expressions of EGFR and NUDT1 were significantly downregulated after miR-145 transfection in human lung adenocarcinoma cells. Our results demonstrated miR-145 in the negative regulation of EGFR and NUDT1 expressions at both mRNA and protein levels. Further analysis showed that miR-145 has the ability to inhibit cell proliferation on transfected lung adenocarcinoma cells over three time points (24, 48 and 72 hours). Upregulation of miR-145 appeared to be an important gene regulation mechanism for the proliferation of lung adenocarcinoma cells and it correlated strongly with the downregulation of EGFR and NUDT1. Interestingly, our study revealed that the altered proliferation in lung cancer cells is not accompanied by changes in apoptosis. Our findings provided new insight into the complex regulating pathway comprising of miR-145, EGFR, NUDT1 and other unknown factors which function in cell proliferation but not in apoptosis. Understanding miR-145's targets and its regulating pathways may lead to new therapeutic strategies for lung adenocarcinoma.
[The incidence and structure of inflammatory diseases of the maxillofacial area based on data from the Surgical Department of Pediatric Dentistry of the 2d Clinic of the Tashkent Medical Institute]. (1990)

Reviews the results of studies of the incidence and structure of inflammatory diseases of the maxillofacial area over 5 years. Defines the major principles of medical rehabilitation of children suffering from inflammatory diseases. Validates the usefulness of special wards for purulent conditions at a department for pediatric oral surgery.