gebhart/patrepeval huggingface dataset:
Enhanced maturation and functional capacity of monocyte‐derived immature dendritic cells by the synthetic immunomodulator Murabutide (2001)

Murabutide is a safe synthetic immunomodulator derived from muramyl dipeptide, the smallest bioactive unit of bacterial peptidoglycan. Although it is well known that muramyl peptides modulate the functions of monocytes/macrophages, their activity on dendritic cells is poorly documented. We thus investigated the effects of Murabutide on immunophenotype, endocytosis, T-cell stimulatory capacity, and cytokine secretion of human monocyte-derived immature dendritic cells (iDCs). We found that Murabutide triggers immunophenotypic changes as upon treatment, iDCs up-regulate the surface expression of the major histocompatibility complex type II molecule human leucocyte antigen-DR, the co-stimulatory molecules CD80, CD86 and CD40 and the differentiation marker CD83, and down-regulate the expression of the mannose receptor. These phenotypic changes are also mirrored by changes in their biological activity. Subsequent to treatment with the synthetic immunomodulator, DC have a decreased endocytic capacity but exhibit enhanced stimulatory capacity for both allogeneic and autologous T cells. In addition, Murabutide-stimulated iDCs have a greater cytostatic activity toward the tumour cell line THP-1. Furthermore, in the presence of Murabutide, DCs transiently increased the release of macrophage inhibitory protein-1 beta, tumour necrosis factor-alpha and interleukin-10, whereas the enhanced production of macrophage-colony stimulating factor was sustained over the 3-day period analysed. In addition, Murabutide triggers the phosphorylation of the three classes of mitogen-activated protein kinases in iDCs. Altogether our results demonstrate that Murabutide triggers the maturation and activation of monocyte-derived iDCs. As this immunomodulator is approved for administration in humans, it could be a useful adjunct to boost the efficacy of DC-based vaccines designed against tumours or virus-infected cells.
Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies. (1988)

Autoantibodies from bullous pemphigoid (BP) patients define a 230-kD protein found in the basement membrane of stratified squamous epithelia. The purpose of this study was to isolate and characterize a cDNA clone with coding sequences for BP antigen. Poly(A+) RNA derived from total RNA of cultured keratinocytes was used, with oligo-dT priming, to construct a cDNA library in the lambda gt11 expression vector, which was screened by the immunoperoxidase method with one BP serum. One darkly stained clone, called here the BP clone, was further characterized. 9 of 9 BP sera, but none of 6 normal and 11 pemphigus sera, bound the plaques of this BP clone. Furthermore, BP IgG affinity purified on plaques of this clone, but not unrelated clones, bound the epidermal basement membrane by immunofluorescence and immunoprecipitated the 230-kD BP antigen from extracts of cultured keratinocytes. Eco RI digestion of the BP clone's cDNA insert demonstrated a 680- and 1,500-bp fragment. Northern blots of total keratinocyte RNA showed that complementary riboprobes transcribed from both fragments hybridized to a 9-kb RNA. Dideoxy DNA sequencing from the 5' end of the BP cDNA demonstrated a 1,992-bp open reading frame, encoding a peptide of 76 kD. This BP cDNA clone will be valuable for understanding the protein structure, expression, and gene organization of BP antigen.
Improving reflection FWI reflectivity using LSRTM in the curvelet domain (2018)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2018Improving reflection FWI reflectivity using LSRTM in the curvelet domainAuthors: Adriano GomesZhuocheng YangAdriano GomesCGG and Zhuocheng YangCGGhttps://doi.org/10.1190/segam2018-2996291.1 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail AbstractWe investigate the benefits of improving the quantitative estimation of reflectivity in reflection FWI (RFWI). This is an important step of the inversion process, since it not only affects the generation of the synthetic reflection data, but also the generation of the "rabbit ears" along the reflection wavepaths. In our approach, the quantitative estimation of reflectivity is performed using least-squares reverse time migration (LSRTM), where the Hessian matrix and its inverse are estimated in the curvelet domain. Using synthetic and field data sets, we show how this approach can improve the reflectivity model and, therefore, benefit the RFWI velocity update. Finally, we discuss some of the limitations of this approach and some of the challenges that are not addressed by it.Presentation Date: Thursday, October 18, 2018Start Time: 8:30:00 AMLocation: 207C (Anaheim Convention Center)Presentation Type: OralKeywords: full-waveform inversion, least squares, reflectionPermalink: https://doi.org/10.1190/segam2018-2996291.1FiguresReferencesRelatedDetailsCited byTime-lag FWI based velocity model and image of a coarse shallow water OBC data setVivek Vandrasi, Mustafa Al-Waily, Sabaresan Mothi, and Alfredo Vasquez30 September 2020Reflection-Waveform Inversion Regularized with Structure-Oriented Smoothing Shaping10 July 2019 | Pure and Applied Geophysics, Vol. 176, No. 12Adaptive quadratic Wasserstein full-waveform inversionDiancheng Wang and Ping Wang10 August 2019 SEG Technical Program Expanded Abstracts 2018ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2018 Pages: 5520 publication data© 2018 Published in electronic format with permission by the Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 27 Aug 2018 CITATION INFORMATION Adriano Gomes and Zhuocheng Yang, (2018), "Improving reflection FWI reflectivity using LSRTM in the curvelet domain," SEG Technical Program Expanded Abstracts : 1248-1252. https://doi.org/10.1190/segam2018-2996291.1 Plain-Language Summary Keywordsfull-waveform inversionleast squaresreflectionPDF DownloadLoading ...
High Channel Mobility in Inversion Layer of SiC MOSFETs for Power Switching Transistors (1999)

A high channel mobility in inversion layers of 4H- and 6H-SiC metal-oxide-semiconductor field-effect-transistors (MOSFETs) was successfully achieved by using the (1120) face instead of the conventional (0001) Si-face. For 4H-SiC, the channel mobility on the (1120) face (95.9 cm2/Vs) was dramatically improved to be 17 times higher than that on the (0001) face (5.6 cm2/Vs). For 6H-SiC, the channel mobility on the (1120) face (115.7 cm2/Vs) was also improved to be 2.5 times higher than that on the (0001) face (44.8 cm2/Vs). These results suggest that the MOS interface quality on the (1120) face is superior to that on the (0001) face. In the case of the (0001) face, 15R-SiC MOSFETs showed a higher channel mobility (59.2 cm2/Vs) than 6H-SiC, due to a higher bulk mobility in 15R-SiC than 6H-SiC.
Androgen actions on the human hair follicle: perspectives (2012)

Androgens stimulate beard growth but suppress hair growth in androgenetic alopecia (AGA). This condition is known as 'androgen paradox'. Human pilosebaceous units possess enough enzymes to form the active androgens testosterone and dihydrotestosterone. In hair follicles, 5α-reductase type 1 and 2, androgen receptors (AR) and AR coactivators can regulate androgen sensitivity of dermal papillae (DP). To regulate hair growth, androgens stimulate production of IGF-1 as positive mediators from beard DP cells and of TGF-β1, TGF-β2, dickkopf1 and IL-6 as negative mediators from balding DP cells. In addition, androgens enhance inducible nitric oxide synthase from occipital DP cells and stem cell factor for positive regulation of hair growth in beard and negative regulation of balding DP cells. Moreover, AGA involves crosstalk between androgen and Wnt/β-catenin signalling. Finally, recent data on susceptibility genes have provided us with the impetus to investigate the molecular pathogenesis of AGA.
Learning an Orchestra Conductor's Technique Using a Wearable Sensor Platform (2007)

Our study focuses on finding new input devices for a system allowing users with any skill to configure and conduct a virtual orchestra in real-time. As a first step, we conducted a user study to learn more about the interaction between a conductor's gestures and the orchestra 's reaction. During an orchestra rehearsal session, we observed a conductor's timing and gestures using the eWatch, a wrist-worn wearable computer and sensor platform. The gestures are analyzed and compared to the music of the orchestra.
FDMA capacity of Gaussian multiple-access channels with ISI (2002)

This paper proposes a numerical method for characterizing the rate region achievable with frequency-division multiple access (FDMA) for a Gaussian multiple-access channel with intersymbol interference. The frequency spectrum is divided into discrete frequency bins and the discrete bin-assignment problem is shown to have a convex relaxation, making it tractable to numerical optimization algorithms. A practical low-complexity algorithm for the two-user case is also proposed. The algorithm is based on the observation that the optimal frequency partition has a two-band structure when the two channels are identical or when the signal-to-noise ratio is high. The simulation result shows that the algorithm performs well in other cases as well. The FDMA-capacity algorithm is used to devise the optimal frequency-division duplex plan for very-high-speed digital subscriber lines.
Molecular dynamics study of nanoparticles and non-ionic surfactant at an oil–water interface (2011)

Nanoparticles (NPs) and surfactants can spontaneously concentrate at the interface between two immiscible liquids, such as oil and water. Systems of high oil–water interfacial area, such as emulsions, are the basis of many industries and consumer products. Although NPs and surfactants are currently incorporated into many of these applications, their mutual interfacial behavior is not completely understood. Here we present molecular dynamics simulations of NPs and non-ionic surfactant in the vicinity of an oil–water interface. It was found that in low concentration the surfactants and NPs show cooperative behavior in lowering the oil–water interfacial tension, while at higher surfactant concentration this synergy is attenuated. It was also found that binding of surfactants to the NP surface decreases the surfactant efficiency in lowering the interfacial tension, while concurrently creating a barrier to NP aggregation.
Temperature of the magnetic nanoparticle microenvironment: estimation from relaxation times (2014)

Accurate temperature measurements are essential to safe and effective thermal therapies for cancer and other diseases. However, conventional thermometry is challenging so using the heating agents themselves as probes allows for ideal local measurements. Here, we present a new noninvasive method for measuring the temperature of the microenvironment surrounding magnetic nanoparticles from the Brownian relaxation time of nanoparticles. Experimentally, the relaxation time can be determined from the nanoparticle magnetization induced by an alternating magnetic field at various applied frequencies. A previously described method for nanoparticle temperature estimation used a low frequency Langevin function description of magnetic dipoles and varied the excitation field amplitude to estimate the energy state distribution and the corresponding temperature. We show that the new method is more accurate than the previous method at higher applied field frequencies that push the system farther from equilibrium.
Channel estimation with superimposed pilot sequence (2003)

For the purpose of various synchronization tasks (including carrier phase, time, frequency, and frame synchronization), one may add a known pilot sequence, typically a pseudo-noise sequence, to the unknown data sequence. This approach is known as a spread-spectrum pilot technique or as a superimposed pilot sequence technique. In this paper, we apply the superimposed pilot sequence technique for the purpose of channel estimation (CE). We propose and verify a truly coherent receiver based on the Viterbi algorithm, which is optimal in the sense of per-survivor processing. We also suggest a generic low-cost receiver structure based on reduced-state sequence estimation. Among the distinct advantages compared to conventional pilot-symbol-assisted CE are (i) a lack of bandwidth expansion and (ii) a significantly improved performance in fast fading environments. The proposed Viterbi receiver may also be used as an alternative receiver for pilot-symbol-assisted CE.
Supporting Overcommitted Virtual Machines through Hardware Spin Detection (2011)

Multiprocessor operating systems (OSs) pose several unique and conflicting challenges to System Virtual Machines (System VMs). For example, most existing system VMs resort to gang scheduling a guest OS's virtual processors (VCPUs) to avoid OS synchronization overhead. However, gang scheduling is infeasible for some application domains, and is inflexible in other domains. In an overcommitted environment, an individual guest OS has more VCPUs than available physical processors (PCPUs), precluding the use of gang scheduling. In such an environment, we demonstrate a more than two-fold increase in application runtime when transparently virtualizing a chip-multiprocessor's cores. To combat this problem, we propose a hardware technique to detect when a VCPU is wasting CPU cycles, and preempt that VCPU to run a different, more productive VCPU. Our technique can dramatically reduce cycles wasted on OS synchronization, without requiring any semantic information from the software. We then present a server consolidation case study to demonstrate the potential of more flexible scheduling policies enabled by our technique. We propose one such policy that logically partitions the CMP cores between guest VMs. This policy increases throughput by 10-25 percent for consolidated server workloads due to improved cache locality and core utilization.
10Be/7Be implies the contribution of stratosphere-troposphere transport to the winter-spring surface O3 variation observed on the Tibetan Plateau (2011)

10Be/7Be is a stratospheric sensitive tracer. In this paper, measurements of 10Be/7Be and surface O3 from October 2005 to May 2006 at Mt. Waliguan (hereafter WLG, 100.898°E, 39.287°N, 3810 m, a.s.l.), China global atmospheric watch (GAW) observatory, are introduced and used to investigate the stratosphere-troposphere transport (STT) and its impact on surface O3 on the Tibetan Plateau. The results show that the magnitude of STT is weak in winter, followed by strengthening from the end of winter to the middle of spring (from mid February to mid April) with large increases in 10Be,7Be,10Be/7Be and surface O3. At the end of spring (from the end of April to mid May in this paper), the STT weakened, and the continuous increase of surface O3 at WLG is produced by tropospheric photochemistry reactions.
Congress, Lobbyists, and Interest Groups (2013)

The first amendment to the constitution provides that Congress may make no law abridging the right of the people to petition the government for a redress of grievances. Court rulings interpret the amendment broadly to include organized and paid representatives of the people, thereby limiting Congress’s ability to regulate lobbying. In practice, interest groups and their lobbyists are a very important means by which the public conveys their expectations and demands to Congress. Nevertheless, Americans believe that members of Congress are beholden to special interests and lobbyists. A November 2012 survey conducted by the Center on Congress at Indiana University found that 67 percent of Americans believe that Congress neither listens nor cares about what ordinary citizens think; more than 81 percent of those surveyed gave Congress a D or F on its ability to control the influence of special interests. In fact, when asked what they thought was the main influence on members of Congress, respondents were more than five times more likely to answer special interests than constituents. A 2010 CBS/The New York Times survey found that 80 percent of Americans agreed that most members of Congress are more interested in serving special interest groups than the people they represent.
Requirements for Subscription to YANG Datastores (2016)

This document provides requirements for a service that allows client
applications to subscribe to updates of a YANG datastore. Based on
criteria negotiated as part of a subscription, updates will be pushed
to targeted recipients. Such a capability eliminates the need for
periodic polling of YANG datastores by applications and fills a
functional gap in existing YANG transports (i.e., Network
Configuration Protocol (NETCONF) and RESTCONF). Such a service can be
summarized as a pub/sub service for YANG datastore updates. Beyond a
set of basic requirements for the service, various refinements are
addressed. These refinements include: periodicity of object updates,
filtering out of objects underneath a requested a subtree, and
delivery QoS guarantees.
Fast events in protein folding: Relaxation dynamics of secondary and tertiary structure in native apomyoglobin (1997)

We report the fast relaxation dynamics of "native" apomyoglobin (pH 5.3) following a 10-ns, laser-induced temperature jump. The structural dynamics are probed using time-resolved infrared spectroscopy. The infrared kinetics monitored within the amide I absorbance of the polypeptide backbone exhibit two distinct relaxation phases which have different spectral signatures and occur on very different time scales (nu = 1633 cm(-1),tau = 48 ns; nu = 1650 cm(-1),tau = 132 micros). We assign these two spectral components to discrete substructures in the protein: helical structure that is solvated (1633 cm(-1)) and native helix that is protected from solvation by interhelix tertiary interactions (1650 cm(-1)). Folding rate coefficients inferred from the observed relaxations at 60 degrees C are k(f)(solvated) = (7 to 20) x 10(6) s(-1) and k(f)(native) = 3.6 x 10(3) s(-1), respectively. The faster rate is interpreted as the intrinsic rate of solvated helix formation, whereas the slower rate is interpreted as the rate of formation of tertiary contacts that determine a native helix. Thus, at 60 degrees C helix formation precedes the formation of tertiary structure by over three orders of magnitude in this protein. Furthermore, the distinct thermodynamics and kinetics observed for the apomyoglobin substructures suggest that they fold independently, or quasi-independently. The observation of inhomogeneous folding for apomyoglobin is remarkable, given the relatively small size and structural simplicity of this protein.
High Ge Content SiGe Selective Processes for Source/Drain in Manufacturing the Next Generations of pMOS Transistors (2013)

Selectivity of different SiGe processes toward oxide and nitride has been studied on both: blanket and patterned Si wafers. Three different precursors: silane, dichlorosilane and disilane were used for SiGe growth. It was found that the growth of SiGe with Ge content higher than 35% was intrinsically selective toward SiO2; SiGe with any Ge content, up to pure Ge, could not be grown selectively toward nitride; in order to get selectivity toward nitride, an etching gas should be used and its amount in the gas phase decreases with an increase of the Ge content.
Expression and Inheritance of a Shriveled‐Seed Mutant in Soybean<sup>1</sup> (1989)

The problem of shriveled or shrunken seed in soybean [ Glycine max (L.) Merr.] has needed genetic definition and characterization. Shriveled or shrunken seed that occur in other crops are known to be due to alterations in genetic information. Genetic information can interact with environmental conditions to produce differing severities of shriveled or shrunken seed. Studies were undertaken to characterize a new shriveled‐seed mutant in soybean. Initial experiments revealed incomplete expressivity and penetrance for the mutant gene. Phytotron studies were conducted to determine the effect of day/night temperatures on the expression of the shriveled‐seed phenotype. The results showed that genotype ✕ environment interaction, particularly the night temperature ✕ genotype interaction, strongly influenced the phenotypic expression. Field studies conducted with F 1 , F 2 , and F 3 plants of reciprocal crosses between the shriveled mutant and ‘Minsoy’ established that the trait is inherited as a single recessive allele. This mutant has been assigned the gene symbol shr by the Soybean Genetics Committee. Linkage tests indicate that the gene is not linked to the W1 , Pb , or T loci.
GABA-A Receptor Ligands and their Therapeutic Potentials (2002)

The GABA(A) receptor system is implicated in a number of neurological diseases, making GABA(A) receptor ligands interesting as potential therapeutic agents. Only a few different classes of structures are currently known as ligands for the GABA recognition site on the GABA(A) receptor complex, reflecting the very strict structural requirements for GABA(A) receptor recognition and activation. Within the series of compounds showing agonist activity at the GABA(A) receptor site that have been developed, most of the ligands are structurally derived from the GABA(A) agonists muscimol, THIP or isoguvacine. Using recombinant GABA(A) receptors, functional selectivity has been shown for a number of compounds such as the GABA(A)agonists imidazole-4-acetic acid and THIP, showing highly subunit-dependent potency and maximal response. In the light of the interest in partial GABA(A) receptor agonists as potential therapeutics, structure-activity studies of a number of analogues of 4-PIOL, a low-efficacy partial GABA(A) agonist, have been performed. In this connection, a series of GABA(A) ligands has been developed showing pharmacological profiles from moderately potent low-efficacy partial GABA(A) agonist activity to potent and selective antagonist effect. Only little information about direct acting GABA(A) receptor agonists in clinical studies is available. Results from clinical studies on the effect of the GABA(A) agonist THIP on human sleep pattern shows that the functional consequences of a direct acting agonist are different from those seen after administration of GABA(A) receptor modulators.
Type of tunable guided-mode resonance filter based on electro-optic characteristic of polymer-dispersed liquid crystal (2010)

A narrowband guided-mode resonance filter (GMRF) incorporating polymer-dispersed liquid crystal (PDLC) is designed. Simulating the characteristics of the filter with rigorous coupled-wave analysis, we find that the resonance wavelength of the new kind of GMRF can be tuned from 672.4 to 698.4 nm by varying the refractive index of the PDLC layer with the applied voltage. Furthermore, the resonance wavelengths vary in a linear fashion with respect to the refractive index of the PDLC layer. Therefore, the desired resonance wavelength can be conveniently selected and tuned in a tuning range of 26 nm by using the applied voltage.
Scheduling algorithms for multi-carrier wireless data systems (2007)

We consider the problem of scheduling wireless data in systems such as 802.16 (WIMAX). Each scheduling decision involves constructing a frame of one or more time slots. Within each time slot multiple carriers must be assigned to users. The important aspect of our problem is that a scheduler knows the channel rates across all users and all carriers whenever a scheduling decision is made. Hence there is no need to treat each carrier in complete isolation. This gives a potential for enhancing performance by allocating multiple carriers simultaneously.