gebhart/patrepeval huggingface dataset:
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis (2009)

Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke. Platelet adhesion, activation, and aggregation at sites of vascular injury are regulated by a diverse repertoire of tyrosine kinase-linked and G protein-coupled receptors. Src family kinases (SFKs) play a central role in initiating and propagating signaling from several platelet surface receptors; however, the underlying mechanism of how SFK activity is regulated in platelets remains unclear. CD148 is the only receptor-like protein tyrosine phosphatase identified in platelets to date. In the present study, we show that mutant mice lacking CD148 exhibited a bleeding tendency and defective arterial thrombosis. Basal SFK activity was found to be markedly reduced in CD148-deficient platelets, resulting in a global hyporesponsiveness to agonists that signal through SFKs, including collagen and fibrinogen. G protein-coupled receptor responses to thrombin and other agonists were also marginally reduced. These results highlight CD148 as a global regulator of platelet activation and a novel antithrombotic drug target.
Angiotensin II type 1 receptor gene A1166C polymorphism is associated with the increased risk of pregnancy-induced hypertension. (2001)

On the basis of the results of our study, we may suggest that AGTR1 gene A1166C polymorphism may predispose women to the development of PIH. It seems that ACE gene I/D and Pst1 RFLP polymorphism, AGT gene M235T polymorphism, and finally chymase gene CMA/B polymorphism do not play any significant role in the pathogenesis of PIH in Caucasian women.
New approach with a Hopfield modeling framework to economic dispatch (2000)

This paper presents a new Hopfield model based approach for the economic dispatch problem of power systems. To solve the economic dispatch problem using the Hopfield model, an energy function composing power mismatch, total fuel cost and the transmission line losses is defined. The weighting factors associated with the terms of the energy function can be either appropriately selected or directly estimated in the proposed model. Which, however, are determined by trial and error in the conventional Hopfield method. To minimize the value of the energy function, the computational procedures including a series of adjusting the weighting factor associated with the transmission line losses and updating the unit generations and power losses are carried out. Because the weighting factors are governed by some relationships developed, adjustment of the weighting factor is much simpler and more effective in steadily achieving solutions than adjustment of the /spl lambda/-multiplier in the lambda-iteration method for economic dispatch problems. Computational results reveal that this approach can find accurate solutions more simply and fast compared with the conventional lambda-iteration method.
Protective Role for Plasmid DNA‐Mediated VIP Gene Transfer in Non‐Obese Diabetic Mice (2006)

Studies focused on the development of diabetes in NOD mice-a model for human type 1 diabetes-have revealed that an autoimmune inflammatory process is produced by the effect of Th1 cells and their secreted cytokines. DNA vaccination has been shown to be an effective method for modulating immunity in viral infections and experimental autoimmune diseases, including diabetes. VIP's immunomodulatory properties are partly mediated by skewing the pattern of cytokines from a proinflammatory response to an anti-inflammatory response. Using gene delivery to express VIP, we interfered in the immune process leading to diabetes in prone, cyclophosphamide-treated NOD mice. Our results extend the role of VIP in the control of immunoregulatory networks and open new perspectives for immunointervention through VIP-based gene therapy.
The Role of Procurement (2013)

Public procurement is the area of public administration concerned with the acquisition by the government of goods, works and services from the market place. These include inputs required to carry out investment projects (e.g., school buildings, roads, ports, technology, etc.) and those for the everyday functioning of government services and operations (fuel, stationery, air tickets, vehicles, etc.).KeywordsCivil SocietyProcurement SystemPublic ProcurementGovernment ProcurementProcurement ProcessThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Epigenetic Regulation of the Electrophysiological Phenotype of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes: Insights for Driven Maturation and Hypertrophic Growth (2013)

Epigenetic regulation is implicated in embryonic development and the control of gene expression in a cell-specific manner. However, little is known about the role of histone methylation changes on human cardiac differentiation and maturation. Using human embryonic stem cells (hESCs) and their derived ventricular (V) cardiomyocytes (CMs) as a model, we examined trimethylation of histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) on promoters of genes associated with cardiac electrophysiology, contraction, and Ca(2+) handling. To avoid ambiguities due to heterogeneous chamber-specific types, hESC-derived ventricular cardiomyocytes (VCMs) were selected by dual zeocin-GFP expression under the transcriptional control of the MLC2v promoter and confirmed electrophysiologically by its signature action potential phenotype. High levels of H3K4me3 are present on pluripotency genes in hESCs with an absence of H3K27me3. Human ESC-VCMS, relative to hESCs, were characterized by a profound loss of H3K27me3 and an enrichment of H3K4me3 marks on cardiac-specific genes, including MYH6, MYH7, MYL2, cTNT, and ANF. Gene transcripts encoding key voltage-gated ion channels and Ca(2+)-handling proteins in hESC-VCMs were significantly increased, which could be attributed to a distinct pattern of differential H3K4me3 and H3K27me3 profiles. Treatment of hESC-VCMs with the histone deacetylase inhibitor valproic acid increased H3K4me3 on gene promoters, induced hypertrophic growth (as gauged by cell volume and capacitance), and augmented cardiac gene expression, but it did not affect electrophysiological properties of these cells. Hence, cardiac differentiation of hESCs involves a dynamic shift in histone methylation, which differentially affects VCM gene expression and function. We conclude that the epigenetic state of hESC-VCMs is dynamic and primed to promote growth and developmental maturation, but that proper environmental stimuli with chromatin remodeling will be required to synergistically trigger global CM maturation to a more adult-like phenotype.
Energy-Efficient Real-Time Scheduling of Tasks with Abortable Critical Sections (2014)

In this paper, an energy-efficient scheduling algorithm, called ceiling-based conditional abortable scheduling (CB-CAS) algorithm, is proposed to schedule periodic hard real-time tasks in a non-ideal DVS processor. Based on the schedulability analysis, CB-CAS calculates a proper processor speed for task execution so that the energy consumption can be reduced without violating the timing constraints of tasks. For saving more energy, we also assume that the critical sections of tasks are abortable, which is a strategy originally proposed to reduce priority inversions. In this paper, CB-CAS introduces a conditional abort rule and a dynamic speed adjustment method to work with the rate monotonic scheduling algorithm and the priority ceiling protocol so that the energy consumption could be reduced further. Whenever two tasks are conflicting for the same resource, CB-CAS will examine the cost of blocking the higher-priority task and the cost of aborting the lower-priority task. CB-CAS will abort the lower-priority task and adjust the processor speed dynamically only if it is more energy efficient. The schedulability analysis and the properties of CB-CAS are given in this paper. The capabilities of CB-CAS were also evaluated by a series of experiments, for which we have some encouraging results.
Somatostatin restrains the secretion of glucagon-like peptide-1 and -2 from isolated perfused porcine ileum (2000)

Suspecting that paracrine inhibition might influence neuronal regulation of the endocrine L cells, we studied the role of somatostatin (SS) in the regulation of the secretion of the proglucagon-derived hormones glucagon-like peptide-1 and -2 (GLP-1 and GLP-2). This was examined using the isolated perfused porcine ileum stimulated with acetylcholine (ACh, 10(-6) M), neuromedin C (NC, 10(-8) M), and electrical nerve stimulation (NS) with or without alpha-adrenergic blockade (phentolamine 10(-5) M), and perfusion with a high-affinity monoclonal antibody against SS. ACh and NC significantly increased GLP secretion, whereas NS had little effect. SS immunoneutralization increased GLP secretion eight- to ninefold but had little influence on the GLP responses to ACh, NC, and NS. Basal SS secretion (mainly SS28) was unaffected by NS alone. Phentolamine + NS and NC abstract strongly stimulated release mainly of SS14, whereas ACh had little effect. Infused intravascularly, SS14 weakly and SS28 strongly inhibited GLP secretion. We conclude that GLP secretion is tonically inhibited by a local release of SS28 from epithelial paracrine cells, whereas SS14, supposedly derived from enteric neurons, only weakly influences GLP secretion.
Homenaje a Joan Ràfols-Casamada (1930-2010). (2011)

In this paper it is presented the contribution of Joan Rafols-Casamada to Agrarian Studies and to Geography, particularly to the research on milk supply and comsumption in Barcelona.
Chemical Properties and Anti-Complementary Activities of Polysaccharide Fractions from Roots and Leaves of<i>Panax ginseng</i> (1989)

Water-soluble and alkaline-soluble polysaccharide fractions, prepared from roots and leaves of PANAX GINSENG C.A. Meyer, were fractionated into strongly acidic, weakly acidic, and neutral polysaccharide fractions by cetyltrimethyammonium bromide, respectively. The roots contained a larger amount of crude polysaccharides than the leaves. These polysaccharide fractions showed different chemical properties, and it was suggested that the roots mainly contained pectins and glucans whereas the leaves mainly contained pectins and heteroglycans. The three water-soluble polysaccharide fractions from the leaves showed higher anti-complementary activity than all corresponding fractions from the roots. However, the three alkaline-soluble polysaccharide fractions from the leaves showed weak activity. Strongly acidic polysaccharide fractions from either roots or leaves decreased the activity after the treatment with periodate indicating the carbohydrate moiety may contribute to the activity.
Stable carbocations. CXXXII. Protonated unsaturated aldehydes and ketones (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStable carbocations. CXXXII. Protonated unsaturated aldehydes and ketonesGeorge A. Olah, Yuval Halpern, Y. K. Mo, and Gao LiangCite this: J. Am. Chem. Soc. 1972, 94, 10, 3554–3561Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/ja00765a049https://doi.org/10.1021/ja00765a049research-articleACS PublicationsRequest reuse permissionsArticle Views212Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Experiences of <i>A+</i> under windows (2002)

article Share on Experiences of A+ under windows Author: Adrian Smith British APL Association British APL AssociationView Profile Authors Info & Claims ACM SIGAPL APL Quote QuadVolume 32Issue 4June 2002 pp 214–218https://doi.org/10.1145/604444.602256Online:01 June 2002Publication History 0citation287DownloadsMetricsTotal Citations0Total Downloads287Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Comparison of cephalometric measurements with digital versus conventional cephalometric analysis (2009)

The aim of this study was to evaluate the accuracy and reliability of angular and linear cephalometric measurements using a computerized method of direct digital radiographs. This was then compared with the measurements obtained with a computerized method that uses a digitizing pad and hand tracing of printout radiographs. Pre-treatment digital cephalometric radiographs of 125 patients were traced using Vistadent 2.1 AT and Jiffy Orthodontic Evaluation (JOE) software programs and by hand tracing of the printouts. Twenty-six anatomical landmarks were defined on each radiograph by a single investigator and 28 variables were calculated. Statistical analysis was undertaken using one-way analysis of variance and multiple group comparisons using Duncan's test at a significance level of 0.05. Low correlation coefficients indicated poor reproducibility for nasolabial angle for each of the three methods (P > 0.05). Most of the variables showed consistency between the three methods except for nasolabial angle, ANS-Me, APFH, L1-NB, Nperp-Pg, Go-Me, and U1-NA measurements. The findings indicated that most of the cephalometric measurements were highly reproducible with direct digital radiographs using Vistadent 2.1 AT as well as with printouts using both JOE software and hand tracing. Despite the low correlation for some measurements between the Vistadent 2.1 AT, JOE, and hand-tracing methods, most of the commonly used measurements were accurate. The user-friendly and time-saving nature of the computerized method using digital radiographs makes it the preferred option.
Membrane Transport Characteristics of Ultrafine Capillaries (1968)

A detailed study and further development of the capillary model for charged wide-pore membranes is presented. Previous work on this model has either linearized the Poisson–Boltzmann equation and/or assumed a small Debye length-to-tube-radius ratio, or ignored axial concentration gradients. None of these simplifications are made here. The problem is characterized by a set of nine coefficients coupling the various transport phenomena. We establish these coefficients and combine them to form “figures of merit” which describe the energy conversion capability of the membrane in its various conversion modes. The capillary membrane is found to be considerably more efficient in electrodialysis than in either osmosis or electro-osmosis.
An optimistic approach in distributed database concurrency control (2013)

In this paper, we present an optimistic concurrency control solution. The proposed solution represents an excellent blossom in the concurrency control field. It deals with the concurrency control anomalies, and, simultaneously, assures the reliability of the data before read-write transactions and after successfully committed. It can be used within the distributed database to track data logs and roll back processes to overcome distributed database anomalies. The method is based on commit timestamps for validation and an integer flag that is incremented each time a successful update on the record is committed.
Nocturnal myoclonus and restless legs syndrome. (1986)

Nocturnal myoclonus (or periodic movements in sleep) consists of stereotyped sleep-related movements of the lower limbs and occasionally also upper limbs, ranging from simple dorsiflexion of the big toe and foot to a triple flexion of the entire leg. It is characterized by a typical periodicity, often occurring in association with sleep arousal phenomena. As an isolated finding (essential nocturnal myoclonus), it represents a paraphysiological phenomenon, also found in normal subjects and developing with advancing age. On the other hand, symptomatic nocturnal myoclonus is typically associated with restless legs syndrome; in this condition, it is usually severe and present also during wakefulness. The exact site of origin of nocturnal myoclonus is unknown. It is almost certainly a subcortical phenomenon, probably modulated in its periodicity by reticular influences. It has frequently been confused with, and should be clearly differentiated from, other normal jerking movements of sleep, such as partial myoclonic jerks and massive myoclonic jerks, or sleep starts. Other abnormal movements that may be confused with nocturnal myoclonus are the startles of hyperekplexia, the syndrome of painful legs and moving toes, nocturnal leg cramps, and the numerous varieties of epileptic myoclonus.
Simulating biped behaviors from human motion data (2007)

Physically based simulation of human motions is an important issue in the context of computer animation, robotics and biomechanics. We present a new technique for allowing our physically-simulated planar biped characters to imitate human behaviors. Our contribution is twofold. We developed an optimization method that transforms any (either motion-captured or kinematically synthesized) biped motion into a physically-feasible, balance-maintaining simulated motion. Our optimization method allows us to collect a rich set of training data that contains stylistic, personality-rich human behaviors. Our controller learning algorithm facilitates the creation and composition of robust dynamic controllers that are learned from training data. We demonstrate a planar articulated character that is dynamically simulated in real time, equipped with an integrated repertoire of motor skills, and controlled interactively to perform desired motions.
After the Storm (2018)

The Tunis Crusade was a fierce war between Christians and Muslims. It brought devastation, disease, and death to many. It was also a negotiation: over money, certainly, but over identity and belonging, too. Out of this potent mix something unexpected emerged: not chaos, not disorder, but new contacts, new relationships, and new alliances, many of them built on a mutual recognition of difference. This chapter argues that the Tunis Crusade was not an unheralded irruption into a Mediterranean world of religious pluralism, many kinds of diversity, and flexible allegiances. It fitted comfortably into that diverse environment and actually helped to produce some of its characteristic cultural expressions. Religious conflict and cultural unity should not be seen as hallmarks of two irreconcilable visions of the medieval Mediterranean world. Both were present in the age of the last European crusader king, coexisting in a dynamic, historically contingent relationship.
Crunching large graphs with commodity processors (2011)

Crunching large graphs is the basis of many emerging applications, such as social network analysis and bioinformatics. Graph analytics algorithms exhibit little locality and therefore present significant performance challenges. Hardware multithreading systems (e.g., Cray XMT) show that with enough concurrency, we can tolerate long latencies. Unfortunately, this solution is not available with commodity parts. Our goal is to develop a latency-tolerant system built out of commodity parts and mostly in software. The proposed system includes a runtime that supports a large number of lightweight contexts, full-bit synchronization and a memory manager that provides a high-latency but high-bandwidth global shared memory. This paper lays out the vision for our system and justifies its feasibility with a performance analysis of the runtime for latency tolerance.
Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer (2007)

Tumor-infiltrating myeloid cells, including tumor-associated macrophages (TAMs), have been implicated in tumor progression. We recently described a lineage of mouse monocytes characterized by expression of the Tie2 angiopoietin receptor and required for the vascularization and growth of several tumor models. Here, we report that TIE2 expression in human blood identifies a subset of monocytes distinct from classical inflammatory monocytes and comprised within the less abundant "resident" population. These TIE2-expressing monocytes (TEMs) accounted for 2% to 7% of blood mononuclear cells in healthy donors and were distinct from rare circulating endothelial cells and progenitors. In human cancer patients, TEMs were observed in the blood and, intriguingly, within the tumors, where they represented the main monocyte population distinct from TAMs. Conversely, TEMs were hardly detected in nonneoplastic tissues. In vitro, TEMs migrated toward angiopoietin-2, a TIE2 ligand released by activated endothelial cells and angiogenic vessels, suggesting a homing mechanism for TEMs to tumors. Purified human TEMs, but not TEM-depleted monocytes, markedly promoted angiogenesis in xenotransplanted human tumors, suggesting a potentially critical role of TEMs in human cancer progression. Human TEMs may provide a novel, biologically relevant marker of angiogenesis and represent a previously unrecognized target of cancer therapy.
Speech coding using trajectory compression and multiple sensors (2004)

This paper presents a new method of multi-frame speech coding based upon polynomial approximation of speech feature trajectories incorporating multiple sensor signals from microphones, accelerometer, electro-glottograph, and microradar. The trajectory polynomial approximation exploits the inter-frame information redundancy encountered in natural speech. The trajectory method is applicable to features such as spectral parameters, gain, and pitch. The method is suitable for application to a frame vocoder to further reduce the transmission bit rate. Multiple transducers increase the intelligibility and quality of the coded speech in noisy environments. Experimental results are obtained by embedding the new method into an enhanced mixed-excitation linear prediction vocoder. The resulting vocoder operates at 1533 bps and preliminary intelligibility and quality tests show results comparable to those of the original 2400 bps vocoder.