gebhart/patrepeval huggingface dataset:
Host range of Rous sarcoma virus pseudotype RSV(HPRS-103) in 12 avian species: support for a new avian retrovirus envelope subgroup, designated J (1992)

The host ranges of the Rous sarcoma virus (RSV) pseudotype RSV(HPRS-103) of a novel avian leukosis virus (ALV), strain HPRS-103, and representative RSV pseudotypes of subgroups A to F, have been determined in embryo fibroblasts from 12 avian species. Domestic fowl, red jungle fowl, Sonnerat’s jungle fowl and turkey were susceptible to infection by RSV(HPRS-103); ring-necked pheasant, Japanese green pheasant, golden pheasant, Japanese quail, guinea-fowl, Peking duck, Muscovy duck and goose were resistant. The host range pattern of RSV(HPRS-103) differs from those of viruses of subgroups A to G and I, and provides support for placing the HPRS-103 strain of ALV in a new envelope subgroup, designated J.
Blends of polypropylene and nylon 6: Influence of the compatibilizer, molecular weight, and processing conditions (1993)

Abstract The aim of this work is to study the influence of different types of compatibilizing agents, different processing conditions, and the molecular weight of the two components on the properties of immiscible blends of polypropylene and nylon 6. Increasing the content of the functional group of the modified polypropylene and the content of nylon in the blend, the effectiveness of the compatibilization improves. The same effect is observed by decreasing the molecular weight of the two components, in particular, that of the polyamide. The influence of the processing conditions is slight provided no degradation takes place during processing. © 1993 John Wiley & Sons, Inc.
Laboratory EXAFS spectrometer with a bent crystal, a solid-state detector, and a fast detection system (1983)

A laboratory x-ray absorption spectrometer is described which consists of a Johansson-cut bent crystal, a rotating anode x-ray generator, and a fast SSD (solid-state detector). Because the SSD can completely discriminate the undesired reflections, contamination of the harmonics is avoided while maintaining a high-source voltage necessary for strong x-ray flux. Fast electronics equipment is employed to keep up with high-x-ray intensity. It is also possible to utilize higher-order reflections for high resolving power. The data of quality comparable to those obtained at synchrotron radiation facilities can be obtained in a comparable period of time. In addition, the determination of the absolute absorbance as defined is possible, which makes the problem of the background subtraction in EXAFS analysis easy.
Interposer design and measurement with various caparcitors for reducing total system PDN impedance (2015)

CMOS digital VLSIs require lower power supply impedance to maintain stable logic operation. This paper reports PDN design and characterization of interposers with different types of decoupling capacitors and different locations. The developed interposer which consisted of six conductive layers was attached on a mother board. Three kinds of locations of decoupling capacitors were examined to reduce power supply impedance. They were die-side capacitors, embedded capacitors, and land-side capacitors on the interposer. Then, three types of capacitors; conventional two-terminal capacitor, L/W reversed type capacitor, and three-terminal capacitor were compared. The CMOS test chip was assumed to synthesize total PDN impedance seen from the chip. By adopting chip-package-board co-design methodology, anti-resonance peaks in total PDN which occured by the interaction between package inductance and on-die capacitance were estimated by simulation.
Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation (2014)

Lipopolysaccharide (LPS), an endotoxin derived from gram-negative bacteria, promotes the secretion of proinflammatory cytokines and mediates endotoxemia through activation of mitogen activated protein kinases, NF-κB, and interferon regulatory factor-3. Silent information regulator transcript-1 (SIRT1), an NAD-dependent deacetylase, mediates NF-κB deacetylation, and inhibits its function. SIRT1 may affect LPS-mediated signaling pathways and endotoxemia. Here we demonstrate that SIRT1 blocks LPS-induced secretion of interleukin 6 and tumor necrosis factor α in murine macrophages, and protects against lethal endotoxic and septic shock in mice. We also demonstrate that interferon β increases SIRT1 expression by activating the Janus kinase--signal transducer and activator of transcription (JAK-STAT) pathway in mouse bone marrow derived macrophages. In vivo treatment of interferon β protects against lethal endotoxic and septic shock, which is abrogated by infection with dominant negative SIRT1-expressing adenovirus. Our work suggests that both SIRT1 and SIRT1-inducing cytokines are useful targets for treating patients with sepsis.
Speech Recognition Under Noise Conditions: Compensation Methods (2007)

In most of the practical applications of Automatic Speech Recognition (ASR), the input speech is contaminated by a background noise. This strongly degrades the performance of speech recognizers The reduction of the accuracy could make unpractical the use of ASR technology in applications that must work in real conditions, where the input speech is usually affected by noise. For this reason, robust speech recognition has become an important focus area of speech research Noise has two main effects over the speech representation: it introduces a distortion in the representation space, and it also causes a loss of information, due to its random nature. The distortion of the representation space due to the noise causes a mismatch between the training (clean) and recognition (noisy) conditions. The acoustic models, trained with speech acquired under clean conditions do not model speech acquired under noisy conditions accurately and this degrades the performance of speech recognizers. Most of the methods for robust speech recognition are mainly concerned with the reduction of this mismatch. On the other hand, the information loss caused by noise introduces a degradation even in the case of an optimal mismatch compensation. In this chapter we analyze the problem of speech recognition under noise conditions. Firstly, we study the effect of the noise over the speech representation and over the recognizer performance. Secondly, we consider two categories of methods for compensating the effect of noise over the speech representation. The first one performs a model-based compensation formulated in a statistical framework. The second one considers the main effect of the noise as a transformation of the representation space and compensates the effect of the noise by applying the inverse transformation.
Looking at Communities and Markets (1999)

The article is about how a discourse on and culture facilitates economic exchanges by lowering transaction costs, especially in poor and marginalized communities. The availability of capital and has been deemed to be a necessary component of the economic development process. Yet those who are poor have little collateral or capital base to qualify for credit. In an effort to expand the availability of to low income communities on non-discriminatory terms, the Equal Credit Opportunities Act and the Community Reinvestment Act were passed. Although this public law framework has been effective at remedying discriminatory lending, I argue that it has been less effective at correcting lending behavior motivated by economic rationale. Banks continue to be unwilling to lend to certain communities because of the high transaction costs involved in screening, monitoring and enforcing small loans. This pattern has been described by economists as rational redlining or credit rationing. Given the limitations of public lawmaking, I argue that the private law model of immigrant communities, which utilizes cohesiveness to manage what I call a community for credit, should supplement the public law framework. I argue that where market imperfections pose barriers to entry, a parallel system of private lawmaking in which people contract back into and status relationships can be effective in promoting economic exchanges that cannot be promoted in the open market. In this respect, the article studies the Korean kye, the Chinese hui, the Ethiopian ekub, and the West Indian esusu, ?- culturally based entities organized wholly outside the formal economy and outside the apparatus of state law. Immigrants who have no resources or history as required by conventional banks rely instead on mechanisms by contributing a set amount into a lending circle, which rotates among members on the basis of need, lottery, or bid. This market for functions only if every member who has already claimed her share of the pot does not default by defecting but rather continues to contribute until the final rotation when every member has had a chance to collect. The community's social capital base of social norms, identity, and trust functions, in essence, as the equivalent of economic collateral. This market is able to maintain its effectiveness only by relying on a number of non-legal measures that lower the screening, monitoring and enforcement costs associated with formal institutional lending. The article thus studies how social capital produces economic capital and concludes by exploring the ways in which the law should react to such entities.
High-speed signal transmission at the front of a bookshelf packaging system (1997)

A front-connection technique using the front-side of the circuit board in rack systems configured like bookshelves is proposed to increase pin-counts for high-throughput switching modules (>20 Gb/s). This configuration technique was implemented using newly developed front connectors and flexible printed-circuit (FPC) cables that are both impedance-matched. This configuration enables the use of a new transmission route that meanders through every signal transmission line of every circuit board, backplane, and FPC cable. This route can extend the functional block size from the size of the circuit board to that of the unit, In a signal transmission experiment between circuit boards with this meander route passing through signal lines of an 18-cm-long FPC cable and over a distance of ten slots in the backplane, error-free (<10/sup -11/) signal transmission of 2/sup 23/-1 nonreturn-to-zero (NRZ) pseudo-random bit sequences (PRBS) at 622.08 Mb/s was obtained.
Lips as Red as Blood: Areca Nut Lip Staining (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
The impact of Rayleigh fading on packet loss in FEC-protected real-time packet-based transmission systems (2007)

This contribution deals with the transmission of video packets over a wireless link subject to slow Rayleigh fading. In order to provide protection against transmission errors and video packet erasures, we apply forward error correction (FEC) both on the physical layer and the packet layer, which involves the transmission of parity bits and parity packets that enable to recover a number of bit errors and packet erasures. We present an expression for the diversity gain provided, in terms of the fading coherence time, the allowable latency, and the allowable transmission overhead.
Rating impairment and disability in Parkinson's disease: Evaluation of the unified Parkinson's disease rating scale (1994)

Although the Unified Parkinson's Disease Rating Scale (UPDRS) is widely used to monitor disease progression and drug efficacy, no attempts have been made to evaluate its scientific and clinical quality. Poor clinical sensibility of items in the activities of daily living (ADL) section and redundancy of items in the motor examination (ME) section prompted us to determine if the number of items in these sections could be reduced to a smaller, equally sensitive set that would describe the data as reliably as did the original set of items. Therefore, we assessed 111 patients with idiopathic Parkinson's disease on the UPDRS and Hoehn and Yahr staging scales. Our results show that the ADL (13 items) and ME (14 items) sections can be reduced to 8 items each without loss of reliability or validity. Our report is preliminary and needs validation.
Time-Lapse Filtering and Improved Repeatability with Automatic Factorial Co-Kriging, AFACK (2002)

A-18 TIME-LAPSE FILTERING AND IMPROVED REPEATABILITY WITH AUTOMATIC FACTORIAL CO-KRIGING (AFACK) T. COLEOU Summary 1 Acquisition and processing imprints are considered negligible with standard 3D processing but become critical when computing time-lapse seismic differences. A new technique AFACK particularly effective for equalising surveys and removing unwanted imprints is presented here. It uses an automated version of a geostatistical technique called Factorial Co-Kriging. Variograms and cross-variograms also provide a measure of the spatial cross variability that lead to a good indicator of spatial repeatability. Introduction CGG Vantage West Great West Road Brentford Middlesex TW8 9GG UK Geostatistics is widely used in
Code assignment for hidden terminal interference avoidance in multihop packet radio networks (1995)

Hidden terminal interference is caused by the (quasi-) simultaneous transmission of two stations that cannot hear each other, but are both received by the same destination station. This interference lowers the system throughput and increases the average packet delay. Some random access protocols that reduce this interference have been proposed, e.g., BTMA protocol. However, the hidden terminal interference can be totally avoided only by means of code division multiple access (CDMA) schemes. In the paper, the authors investigate the problem of assigning orthogonal codes to stations so as to eliminate the hidden terminal interference. Since the codes share the fixed channel capacity allocated to the network in the design stage, their number must not exceed a given bound. The authors seek assignments that minimize the number of codes used. They show that this problem is NP-complete, and thus computationally intractable, even for very restricted but very realistic network topologies. Then, they present optimal algorithms for further restricted topologies, as well as fast suboptimal centralized and distributed heuristic algorithms. The results of extensive simulation set up to derive the average performance of the proposed heuristics on realistic network topologies are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
α-Methylacyl-CoA Racemase from Mycobacterium tuberculosis (2005)

Alpha-methylacyl-CoA racemase (Amacr) catalyzes the racemization of alpha-methyl-branched CoA esters. Sequence comparisons have shown that this enzyme is a member of the family III CoA transferases. The mammalian Amacr is involved in bile acid synthesis and branched-chain fatty acid degradation. In human, mutated variants of Amacr have been shown to be associated with disease states. Amino acid sequence alignment of Amacrs and its homologues from various species revealed 26 conserved protic residues, assumed to be potential candidates as catalytic residues. Amacr from Mycobacterium tuberculosis (MCR) was taken as a representative of the racemases. To determine their importance for efficient catalysis, each of these 26 protic residues of MCR was mutated into an alanine, respectively, and the mutated variants were overexpressed in Escherichia coli. It was found that four variants (R91A, H126A, D156A, and E241A) were properly folded but had much decreased catalytic efficiency. Apparently, Arg91, His126, Asp156, and Glu241 are important catalytic residues of MCR. The importance of these residues for catalysis can be rationalized by the 1.8 A resolution crystal structure of MCR, which shows that the catalytic site is at the interface between the large and small domain of two different subunits of the dimeric enzyme. This crystal structure is the first structure of a complete enzyme of the bile acid synthesis pathway. It shows that MCR has unique structural features, not seen in the structures of the sequence related formyl-CoA transferases, suggesting that the family III CoA transferases can be subdivided in at least two classes, being racemases and CoA transferases.
Single-molecule Detection in situ (2009)

The human body contains a variety of different cell types that share a common genome, but differ in how they use the information encoded therein. Variation in molecular content exists even at the level of individual cells, and to provide deeper insight into complex cellular processes methods that permit analysis of each cell on its own are needed. This thesis presents molecular methods for localized detection of individual nucleic acid molecules. The developed methods are based on padlock probes and target-primed rolling circle amplification. Single-molecule detection sensitivity in combination with single-nucleotide genotyping selectivity enables detection of allelic DNA variants and closely related target sequences directly in cells. Padlock probes further enable multiplex detection of targets, and in combination with image analysis quantitative molecular data for individual cells can be acquired for large cell populations at a resolution that no other in situ detection method can provide at present. In this thesis, the in situ target-primed rolling circle amplification technique was first used for genotyping of a point mutation in the mitochondrial genome with padlock probes. This displayed mitochondrial DNA heterogeneity in cell populations. Application of the method on comet assay preparations showed that mitochondrial genomes are lost from these samples prior to analysis. Nuclear DNA targets, however, can be efficiently detected in corresponding samples. Padlock probes and rolling circle amplification are thus an attractive alternative to FISH analysis for localized DNA detection in comet assay samples. A method was also developed for localized detection of individual mRNA molecules with padlock probes and rolling circle amplification. This method provides unique possibilities to genotype allelic variants of transcripts in situ. mRNA expression is associated with substantial cell-to-cell variation and our presented method permits simultaneous visualization of multiple transcripts directly in complex tissue samples. Application of the methods presented in this thesis will enable new types of studies of biological samples from both normal and disease states.
Mitotic Degradation of Human Thymidine Kinase 1 Is Dependent on the Anaphase-Promoting Complex/Cyclosome–Cdh1-Mediated Pathway (2003)

The expression of human thymidine kinase 1 (hTK1) is highly dependent on the growth states and cell cycle stages in mammalian cells. The amount of hTK1 is significantly increased in the cells during progression to the S and M phases, and becomes barely detectable in the early G(1) phase by a proteolytic control during mitotic exit. This tight regulation is important for providing the correct pool of dTTP for DNA synthesis at the right time in the cell cycle. Here, we investigated the mechanism responsible for mitotic degradation of hTK1. We show that hTK1 is degraded via a ubiquitin-proteasome pathway in mammalian cells and that anaphase-promoting complex/cyclosome (APC/C) activator Cdh1 is not only a necessary but also a rate-limiting factor for mitotic degradation of hTK1. Furthermore, a KEN box sequence located in the C-terminal region of hTK1 is required for its mitotic degradation and interaction capability with Cdh1. By in vitro ubiquitinylation assays, we demonstrated that hTK1 is targeted for degradation by the APC/C-Cdh1 ubiquitin ligase dependent on this KEN box motif. Taken together, we concluded that activation of the APC/C-Cdh1 complex during mitotic exit controls timing of hTK1 destruction, thus effectively minimizing dTTP formation from the salvage pathway in the early G(1) phase of the cell cycle in mammalian cells.
Radiation-induced cationic polymerization of limonene oxide,. cap alpha. -pinene oxide, and. beta. -pinene oxide (1984)

After suitable drying, the subject monomers in the form of neat liquids undergo radiation-induced polymerization with no apparent side reactions and high conversions to precipitatable polymers of low molecular weight. A cationic mechanism is evidenced by the strongly retarding effect of tri-n-propylamine on the polymerization rate. At 25/sup 0/C, limonene oxide gives the highest polymerization rates, an average conversion of 36% per Mrad being obtained in comparison with values of 5.7 and 7.3% per Mrad for the ..cap alpha..-pinene and ..beta..-pinene oxides, respectively. Similarly, the average anti DP/sub n/ decreases from 11.8 for the limonene oxide polymer to 5.6 and 4.0 for the ..cap alpha..-pinene oxide and ..beta..-pinene oxide polymers, respectively. A high frequency of chain transfer to monomer is indicated in each case by the fact that the kinetic chain lengths are estimated to be on the order of a hundred times larger than the anti DP/sub n/ values. Structural characterization of the limonene oxide polymer by /sup 1/H and /sup 13/C NMR spectroscopy provides conclusive evidence that the polymerization proceeds by the opening of the epoxide ring to yield a 1,2-trans polyether. Similar NMR studies on the polymers formed from the ..cap alpha..-pinene and ..beta..-pinene oxides show thatmore » in the polymerization of these monomers, the opening of the epoxide ring is generally accompanied by the concomitant ring opening of the cyclobutane ring structure to yield a gem-dimethyl group in the main chain. The detection of isopropenyl end groups in the pinene oxide polymers is also consistent with this mode of propagation being followed by chain (proton) transfer to monomer.« less
Radioimmunoassay of human fibrinopeptide B and kinetics of fibrinopeptide cleavage by different enzymes. (1975)

A B S T R A C T Thrombin converts fibrinogen to fibrin monomer by cleaving fibrinopeptides A and B (FPA and FPB) from the amino terminal ends of the A(a) and B (P) chains. A radioimmunoassay capable of mea- suring the A peptide in human blood as an index of thrombin action in vivo has been described previously. This paper describes the development of a radioim- munoassay for FPB and the use of both assays in the demonstration of distinctive patterns of cleavage of the amino terminal ends of the A(a) and B(P) chains of fibrinogen by various enzymes.
Rapeseed meal and egg taint: Treatment of rapeseed meal to reduce tainting potential (1979)

1. Treatment of rapeseed meal with calcium hydroxide suspension decreased the sinapine content by up to 90%. Smaller decreases were obtained by autolysis, steaming and treatment with ammonia. 2. When this treated meal was fed to susceptible ("tainting") hens the concentration of trimethylamine in the eggs was decreased to much less than that required to cause taint.