gebhart/patrepeval huggingface dataset:
[Choosing the adequate antidepressant focusing on efficacy, tolerability and its predictors]. (2012)

Major depressive disorder is a debilitating disease that imposes significant burden not only on patients but also on society for its high prevalence and association with serious consequences such as suicide and substantial negative impact on social health, with both direct and indirect considerable costs worldwide. Selective serotonin reuptake inhibitors (SSRIs) treatment was introduced 12 years ago and reduced morbidity of major depressive disorder with a favorable side effect profile. However, unfortunately, not all individuals benefit from treatment and 30-40% of patients do not show a complete response to treatment. Clinical guideline does not show which antidepressant is the most appropriate to the patient just in front of you in clinical setting but simply suggest 'use the new antidepressant such as SSRI, SNRI, mirtazapine as first line therapy' or 'be vigilant for side effect'. In this paper, I summarized the considerable evidence such as meta-analysis, guideline and double blind randomized controlled trial to detect the most appropriate pharmacotherapy as first-line and second or later therapy including treatment resistant depression from the some specific factors point of view; specific feature of symptom, ethnicity and genetic feature.
X-ray photoelectron spectroscopy and high resolution electron microscopy studies of Aurivillius compounds: Bi4−xLaxTi3O12(x=0, 0.5, 0.75, 1.0, 1.5, and 2.0) (2002)

In order to determine the fatigue-free origin of the ferroelectric Bi3.25La0.75Ti3O12, a series of x-ray photoelectron spectroscopy and high resolution electron microscopy studies were performed on the polycrystalline Bi4−xLaxTi3O12 (BLTx, x=0, 0.5, 0.75, 1.0, 1.5, and 2.0) powders. From the XPS study, the surfaces of all La-containing compounds are found to consist of one outermost Bi-rich region and followed by a La-rich region, instead of the chemical stoichiometry in the bulk. An HREM study on Bi3.25La0.75Ti3O12 further confirms that this surface configuration arises from some intergrowth defects with a thickness of 5 nm appearing on the crystal edge, which is also observed in compounds with x=1.0 and 2.0, but not in the poor fatigue-resistant Bi4Ti3O12 (x=0). This La-induced defect locally changes the chemical composition of the crystal surface, which probably possesses a different physical characteristic as compared to the bulk. Consequently, it could can be the physical nature of the interface, when in contact with the metal electrode, Pt, in ferroelectric nonvolatile memory. Since the fatigue phenomenon on a ferroelectric capacitor arises predominately from the pinning of domain walls on the metal-ferroelectric interface, the surface configurations of La-containing Bi4Ti3O12 compounds should be considered as one of the fatigue-free factors as well as the self-regulation of the Bi2O2 layer and the chemical stability of the perovskite slabs. In addition, the band gap of Bi3.25La0.75Ti3O12 is also estimated by UV absorption spectrum to be 3.9±0.1 eV.
Effect of quantization on video compression (2003)

The intra (I) or inter (P-forward prediction) frame in the given video sequence are compressed in wavelet domain. The intra frames are wavelet transformed with three levels, coded and quantized using SPIHT (Set Partitioning in Hierarchical Tree) and run-length coding. The inter frames of video sequence are wavelet transformed with three levels and encoded by forward prediction from the preceding wavelet transform and SPIHT decoded frames. Multi-resolution motion estimation and compensation is done in wavelet domain. Motion vectors so produced are coded using zero tree motion vector coder. Motion compensated wavelet coefficients are quantized and coded using SPIHT and run-length coder. The video decoder is an exact reverse of the video encoder.
Decoding of tandem quadruplets by adjacent tRNAs with eight-base anticodon loops (2000)

To expand the genetic code for specification of multiple non-natural amino acids, unique codons for these novel amino acids are needed. As part of a study of the potential of quadruplets as codons, the decoding of tandem UAGA quadruplets by an engineered tRNA(Leu) with an eight-base anticodon loop, has been investigated. When GCC is the codon immediately 5' of the first UAGA quadruplet, and release factor 1 is partially inactivated, the tandem UAGAs specify two leucines with an overall efficiency of at least 10%. The presence of a purine at anticodon loop position 32 of the tRNA decoding the codon 5' to the first UAGA seems to influence translation of the following codon. Another finding is intraribosomal dissociation of anticodons from codons and their re-pairing to mRNA at overlapping or nearby codons. In one case where GCC is replaced by CGG, only a single Watson-Crick base pair can form upon re-pairing when decoding is resumed. This has implications for the mechanism of some cases of programmed frameshifting.
Activity of KRM-1648, a new benzoxazinorifamycin, against Mycobacterium tuberculosis in a murine model (1994)

The activity of KRM-1648 was evaluated in a murine model of tuberculosis. Approximately 10(7) viable Mycobacterium tuberculosis ATCC 35801 organisms were given intravenously to 4-week-old female outbred mice. Treatment was started 1 week postinfection and given by gavage for 4 weeks. Viable-cell counts were determined from homogenates of spleen and lung tissues. The activity of KRM-1648 was compared with those of rifampin and rifabutin at 20 mg/kg of body weight. KRM-1648 was more active than either rifampin or rifabutin against organisms in spleens and lungs. KRM-1648 alone and in combination with either isoniazid, ethambutol, pyrazinamide, or levofloxacin was evaluated. Other treatment groups received isoniazid, ethambutol, pyrazinamide, or levofloxacin as single agents. KRM-1648 was the most active single agent evaluated. KRM-1648-pyrazinamide and KRM-1648-isoniazid were the most active combinations. These combinations were more active than KRM-1648 alone. The promising activity of KRM-1648 in M. tuberculosis-infected mice suggests that it is a good candidate for clinical development as a new antituberculosis agent.
Composting prison food residuals (1997)

Correctional facility in Connecticut operates demonstration project to help achieve state recycling goals.
Association Between Toenail Selenium and Risk of Acute Myocardial Infarction in European Men: The EURAMIC Study (1997)

The association between selenium status and risk of acute myocardial infarction was examined in a multicenter case-control study in 10 centers from Europe and Israel in 1991-1992. Selenium in toenails was assessed for 683 nonfatal male cases with first acute myocardial infarction and 729 controls less than 70 years of age. Median toenail selenium content was 0.553 microgram/g for cases and 0.590 microgram/g for controls. After adjustment for age, center, and smoking, the odds ratio for myocardial infarction in the highest quintile of selenium as compared with the lowest was 0.63 (95 percent confidence interval 0.37-1.07, p for trend = 0.08). The observed inverse trend was somewhat stronger when the authors adjusted for vitamin E status (p = 0.05). Analysis stratified for smoking habits showed an inverse association in former smokers (odds ratio for the 75th-25th percentile contrast = 0.63 (95 percent confidence interval 0.43-0.94)), but not in current smokers (odds ratio = 0.97 (0.71-1.32)) or in those who had never smoked (odds ratio = 1.55 (0.87-2.76)). Analysis stratified by center showed a significant inverse association between selenium levels and risk of myocardial infarction for Germany (Berlin) only (75th to 25th percentile odds ratio = 0.62 (95 percent confidence interval 0.42-0.91)), which was the center with the lowest selenium levels. It appears that the increased risk of acute myocardial infarction at low levels of selenium intake is largely explained by cigarette smoking; selenium status does not appear to be an important determinant of risk of myocardial infarction at the levels observed in a large part of Europe.
On the Future of Problem Solving Environments (2000)

In this paper we review the current state of the problem solving environment (PSE) field and make projections for the future. First we describe the computing context, the definition of a PSE and the goals of a PSE. The state-of-the-art is summarized along with sources (books, bibliographics, web sites) of more detailed information. The principal components and paradigms for building PSEs are presented. The discussion of the future is given in three parts: future trends, scenarios for 2010/2025, and research
Endocrine-Disrupting Chemicals: Associated Disorders and Mechanisms of Action (2012)

The incidence and/or prevalence of health problems associated with endocrine-disruption have increased. Many chemicals have endocrine-disrupting properties, including bisphenol A, some organochlorines, polybrominated flame retardants, perfluorinated substances, alkylphenols, phthalates, pesticides, polycyclic aromatic hydrocarbons, alkylphenols, solvents, and some household products including some cleaning products, air fresheners, hair dyes, cosmetics, and sunscreens. Even some metals were shown to have endocrine-disrupting properties. Many observations suggesting that endocrine disruptors do contribute to cancer, diabetes, obesity, the metabolic syndrome, and infertility are listed in this paper. An overview is presented of mechanisms contributing to endocrine disruption. Endocrine disruptors can act through classical nuclear receptors, but also through estrogen-related receptors, membrane-bound estrogen-receptors, and interaction with targets in the cytosol resulting in activation of the Src/Ras/Erk pathway or modulation of nitric oxide. In addition, changes in metabolism of endogenous hormones, cross-talk between genomic and nongenomic pathways, cross talk with estrogen receptors after binding on other receptors, interference with feedback regulation and neuroendocrine cells, changes in DNA methylation or histone modifications, and genomic instability by interference with the spindle figure can play a role. Also it was found that effects of receptor activation can differ in function of the ligand.
The chemokine family. Potential therapeutic targets from allergy to HIV infection. (1999)

Basal trafficking and homing of leukocytes is controlled by a large subfamily of cytokines, the chemokines. The initiation and perpetuation of an inflammatory response is also mediated by the chemokines. The chemokine family acts through a sub-family of the seven transmembrane, G-protein-coupled receptor class. Despite the large number of chemokine proteins, several factors such as regulated expression of the ligands and their receptors, glycosoaminoglycan interactions and their signaling mechanisms introduce the required selectivity in vivo. Recently, chemokine receptors have been identified as an essential component for the infection of host cells by HIV. Chemokine receptors thus present an attractive therapeutic target for inflammatory disorders and HIV infection, and evidence for their validation using antibodies and receptor antagonists is discussed.
Laminin 10/11: an alternative adhesive ligand for epidermal keratinocytes with a functional role in promoting proliferation and migration (2002)

We have investigated the expression and function of the isoforms of laminin bearing the alpha5 chain, i.e. laminin-10/11 in neonatal and adult human skin. By immunostaining human skin derived from a variety of anatomic sites, we found that the laminin-alpha5 chain is expressed abundantly in the basement membrane underlying the interfollicular epidermis and the blood vessels in the dermis. Interestingly, while the expression level of the well-studied laminin-5 isoform did not change significantly with age, laminin-10/11 (alpha5 chain) appeared to decrease in the basement membrane underlying the epidermis, in adult skin. In contrast, the levels of laminin-10/11 in the basement membrane underlying blood vessels remained unchanged in neonatal vs. adult skin. Importantly, in vitro cell adhesion assays demonstrated that laminin-10/11 is a potent adhesive substrate for both neonatal and adult keratinocytes and that this adhesion is mediated by the alpha3beta1 and alpha6beta4 integrins. Adhesion assays performed with fractionated basal keratinocytes showed that stem cells, transit amplifying cells and early differentiating cells all adhere to purified laminin-10/11 via these receptors. Further, laminin-10/11 provided a proliferative signal for neonatal foreskin keratinocytes, adult breast skin keratinocytes, and even a human papillomavirus type-18 transformed tumorigenic keratinocyte cell line in vitro. Finally, laminin-10/11 was shown to stimulate keratinocyte migration in an in vitro wound healing assay. These results provide strong evidence for a functional role for laminin-10/11 in epidermal proliferation during homeostasis, wound healing and neoplasia.
Detection and Characterization of Shiga Toxigenic <i>Escherichia coli</i> by Using Multiplex PCR Assays for <i>stx</i> <sub>1</sub> , <i>stx</i> <sub>2</sub> , <i>eaeA</i> , Enterohemorrhagic <i>E. coli hlyA</i> , <i>rfb</i> <sub>O111</sub> , and <i>rfb</i> <sub>O157</sub> (1998)

Shiga toxigenic Escherichia coli (STEC) comprises a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, certain strains appear to be of greater virulence for humans, for example, those belonging to serogroups O111 and O157 and those with particular combinations of other putative virulence traits. We have developed two multiplex PCR assays for the detection and genetic characterization of STEC in cultures of feces or foodstuffs. Assay 1 utilizes four PCR primer pairs and detects the presence of stx1, stx2 (including variants of stx2), eaeA, and enterohemorrhagic E. coli hlyA, generating amplification products of 180, 255, 384, and 534 bp, respectively. Assay 2 uses two primer pairs specific for portions of the rfb (O-antigen-encoding) regions of E. coli serotypes O157 and O111, generating PCR products of 259 and 406 bp, respectively. The two assays were validated by testing 52 previously characterized STEC strains and observing 100% agreement with previous results. Moreover, assay 2 did not give a false-positive O157 reaction with enteropathogenic E. coli strains belonging to clonally related serogroup O55. Assays 1 and 2 detected STEC of the appropriate genotype in primary fecal cultures from five patients with hemolytic-uremic syndrome and three with bloody diarrhea. Thirty-one other primary fecal cultures from patients without evidence of STEC infection were negative.
Respiration Rate Estimation with Depth Cameras (2018)

Depth cameras have been known to be capable of picking up the small changes in distance from users' torsos, to estimate respiration rate. Several studies have shown that under certain conditions, the respiration rate from a non-mobile user facing the camera can be accurately estimated from parts of the depth data. It is however to date not clear, what factors might hinder the application of this technology in any setting, what areas of the torso need to be observed, and how readings are affected for persons at larger distances from the RGB-D camera. In this paper, we present a benchmark dataset that consists of the point cloud data from a depth camera, which monitors 7 volunteers at variable distances, for variable methods to pin-point the person's torso, and at variable breathing rates. Our findings show that the respiration signal's signal-to-noise ratio becomes debilitating as the distance to the person approaches 4 metres, and that bigger windows over the person's chest work particularly well. The sampling rate of the depth camera was also found to impact the signal's quality significantly.
A Reversible Electron-Bifurcating Ferredoxin- and NAD-Dependent [FeFe]-Hydrogenase (HydABC) in Moorella thermoacetica (2013)

Moorella thermoacetica was long the only model organism used to study the biochemistry of acetogenesis from CO(2). Depending on the growth substrate, this Gram-positive bacterium can either form H(2) or consume it. Despite the importance of H(2) in its metabolism, a hydrogenase from the organism has not yet been characterized. We report here the purification and properties of an electron-bifurcating [FeFe]-hydrogenase from M. thermoacetica and show that the cytoplasmic enzyme efficiently catalyzes both H(2) formation and H(2) uptake. The purified heterotrimeric iron-sulfur flavoprotein (HydABC) catalyzed the coupled reduction of ferredoxin (Fd) and NAD(+) with H(2) at 55 °C at pH 7.5 at a specific rate of about 100 μmol min(-1) mg protein(-1) and the reverse reaction, the coupled reduction of protons to H(2) with reduced ferredoxin and NADH, at a specific rate of about 10 μmol min(-1) mg protein(-1) in the stoichiometry Fd(ox) + NAD(+) + 2H(2) Fd(red)(2-) + NADH + 3H(+). When ferredoxin from Clostridium pasteurianum, NAD(+), and the enzyme were incubated at pH 7.0 under 100% H(2) in the gas phase (E(0)' = -414 mV), more than 95% of the ferredoxin (E(0)' = -400 mV) was reduced, which indicated that ferredoxin reduction with H(2) is driven by the exergonic reduction of NAD(+) (E(0)' = -320 mV) with H(2). In the absence of NAD(+), ferredoxin was not reduced. We identified the genes encoding HydABC within the transcriptional unit hydCBAX and mapped the transcription start site.
Subwavelength imaging in photonic crystals (2003)

We investigate the transmission of evanescent waves through a slab of photonic crystal and explore the recently suggested possibility of focusing light with subwavelength resolution. The amplification of near-field waves is shown to rely on resonant coupling mechanisms to surface photon bound states, and the negative refractive index is only one way of realizing this effect. It is found that the periodicity of the photonic crystal imposes an upper cutoff to the transverse wave vector of evanescent waves that can be amplified, and thus a photonic-crystal superlens is free of divergences even in the lossless case. A detailed numerical study of the optical image of such a superlens in two dimensions reveals a subtle and very important interplay between propagating waves and evanescent waves on the final image formation. Particular features that arise due to the presence of near-field light are discussed.
Ion-beam lithography for IC fabrication with submicrometer features (1979)

We report an entirely new pattern-replication technique for IC fabrication. It has demonstrated submicrometer (&lt;0.5 μm) resolution and it has the capability of large throughput (wafer-levels/h). It utilizes high-energy protons as the exposing radiation through a mask placed in proximity to a wafer covered with resist. We call this new technique ’’ion-beam lithography’’ (IBL). System parameters and measurements relevant to the use of IBL as a production technology are discussed and SEM micrographs of submicrometer patterns in PMMA are presented. The technique is similar to x-ray lithography, in that a pattern is produced in a thin resist film after exposing it to radiation through a mask. High-energy protons have the same advantage as x rays in eliminating wavelength diffraction problems which limit the resolution of photolithography. Also, a gap (∠15–25 μm) is permitted between the mask and wafer. Ions have an advantage over x rays in that penumbral distortion is avoided by using highly collimated ion beams which are available with present state of the art; ions are collimated using conventional ion-optical techniques, whereas use of a distant ’’point’’ source is the only feasible scheme for collimation of x rays.
Overexpression of a Rice NPR1 Homolog Leads to Constitutive Activation of Defense Response and Hypersensitivity to Light (2005)

Arabidopsis NPR1/NIM1 is a key regulator of systemic acquired resistance (SAR), which confers lasting broad-spectrum resistance. Previous reports indicate that rice has a disease-resistance pathway similar to the Arabidopsis SAR pathway. Here we report the isolation and characterization of a rice NPR1 homologue (NH1). Transgenic rice plants overexpressing NH1 (NH1ox) acquire high levels of resistance to Xanthomonas oryzae pv. oryzae. The resistance phenotype is heritable and correlates with the presence of the transgene and reduced bacterial growth. Northern analysis shows that NH1ox rice spontaneously activates defense genes, contrasting with NPR1-overexpressing Arabidopsis, where defense genes are not activated until induction. Wild-type NH1, but not a point mutant corresponding to npr1-1, interacts strongly with the rice transcription factor rTGA2.2 in yeast two-hybrid. Greenhouse-grown NH1ox plants develop lesion-mimic spots on leaves at preflowering stage although no other developmental effects are observed. However, when grown in growth chambers (GCs) under low light, NH1ox plants are dwarfed, indicating elevated sensitivity to light. The GC-grown NH1ox plants show much higher salicylic acid (SA) levels than the wild type, whereas greenhouse-grown NH1ox plants contain lower SA. These results indicate that NH1 may be involved in the regulation of SA in response to environmental changes.
The Neurological Examination of the Full Term Newborn Infant. (1964)

Dr. Prechtl's manual on the neurological examination of the newborn infant will be welcomed by clinicians and researchers alike. It aims to introduce a method of standardization in appraising newborn reflexes. Because of inadequate standardization, it has heretofore been difficult to detect signs of brain damage during the neonatal period, or prior to the beginning maturation of cortical cells. Now that knowledge of neural functioning in the brain stem, especially the reticular activating system, is advancing, the reflex behavior of the newborn takes on greater significance and warrants careful investigation. The text provides a simplified way of coding and recording reflex behavior. A common method of recording will be invaluable to the various investigators who are once again devoting attention to the significance of newborn behavior. Publication of a follow-up study of the development of the same children upon whom these standardizations were based is promised forthwith. This publication is
CipherVOX: scalable low-complexity speaker verification (2002)

Biometrics is gaining strong support for access control in the industry. It is not uncommon for individual users to be faced with a half-dozen or more passwords and personal identification numbers (PINs) controlling access to the systems required for them to do their job. The ubiquity of passwords actually relaxes system security since many users tend to use the same password across all applications, or collect the various passwords in a single location (perhaps a password protected spreadsheet, or a piece of paper in a desk drawer). The latter case is of extreme concern since security around the collection is much more easily compromised than that of the system. The use of biometrics not only recovers the ability to secure sensitive systems and data, but also does so in a user-friendly manner. In order to use biometrics successfully in server-based environments, several key concerns must be addressed. First, the authentication strategy must maintain acceptable levels of security. Second, the user community must accept the chosen biometric (unless there is a captive audience). The last major consideration is the scalability of the solution. In this paper we introduce CipherVOX, a speaker verification access control solution for server and standalone computing environments. We discuss the use of our polynomial-based classifier that combines high-accuracy and low-complexity via discriminative techniques, and give performance results for both a proprietary performance database and the standard YOHO database. We also review the challenges in designing for user acceptance, including the design of the speaker verification user interface, as well as the application programming interface (API).