gebhart/patrepeval huggingface dataset:
Enzymatic dehalogenation of gas phase substrates with haloalkane dehalogenase (2000)

Haloalkane dehalogenase is an enzyme capable of catalyzing the conversion of short-chained (C2–C8) aliphatic halogenated hydrocarbons to a corresponding primary alcohol. Because of its broad substrate specificity for mono-, di-, and trisubstituted halogenated hydrocarbons and cofactor independence, haloalkane dehalogenases are attractive biocatalysts for gas-phase bioremediation of pollutant halogenated vapor emissions. A solid preparation of haloalkane dehalogenase from Rhodococcus rhodochrous was used to catalyze the dehalogenation reaction of 1-chlorobutane or 1,3-dichloropropane delivered in the gas phase. For optimal gas-phase dehalogenase activity, a relative humidity of 100%, aw = 1, was desired. With a 50% reduction in the vapor-phase hydration level, an 80% decrease in enzymatic activity was observed. The enzyme kinetics for the gas-phase substrates obeyed an Arrhenius-“like” behavior and the solid haloalkane dehalogenase preparation was more thermally stable than its water-soluble equivalent. Triethylamine was added to the gaseous reaction environment in efforts to increase the rate of reaction. A tenfold increase in the dehalogenase activity for the vapor-phase substrates was observed with the addition of triethylamine. Triethylamine altered the electrostatic environment of haloalkane dehalogenase via a basic shift in local pH, thereby minimizing the effect of the pH-reducing reaction product on enzyme activity. Both organic phase and solid-state buffers were used to confirm the activating role of the altered ionization state. © 2000 John Wiley & Sons, Inc., Biotechnol Bioeng 69: 235–241, 2000.
Effects of wrist tendon vibration on arm tracking in people poststroke (2011)

The goal of this study was to evaluate the influence of wrist tendon vibration on a multijoint elbow/shoulder tracking task. We hypothesized that tendon vibration applied at the wrist musculature would improve upper arm tracking performance in chronic stroke survivors through increased, Ia-afferent feedback to the central nervous system (CNS). To test this hypothesis, 10 chronic stroke and 5 neurologically intact subjects grasped the handle of a planar robot as they tracked a target through a horizontal figure-8 pattern. A total of 36 trials were completed by each subject. During the middle trials, 70-Hz tendon vibration was applied at the wrist flexor tendons. Position, velocity, and electromyography data were evaluated to compare the quality of arm movements before, during, and after trials with concurrent vibration. Despite tracking a target that moved at a constant velocity, hand trajectories appeared to be segmented, displaying alternating intervals of acceleration and deceleration. Segments were identifiable in tangential velocity data as single-peaked, bell-shaped speed pulses. When tendon vibration was applied at the wrist musculature, stroke subjects experienced improved tracking performance in that hand path lengths and peak speed variability decreased, whereas movement smoothness increased. These performance improvements were accompanied by decreases in the muscle activity during movement. Possible mechanisms behind improved movement control in response to tendon vibration may include improved sensorimotor integration or improved cortical modulation of spinal reflex activity.
$\beta$ -Ga2O3 MOSFETs for Radio Frequency Operation (2017)

We demonstrate a β-Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> MOSFET with record-high transconductance (gm) of 21 mS/mm and extrinsic cutoff frequency (fT) and maximum oscillating frequency (fmax) of 3.3 and 12.9 GHz, respectively, enabled by implementing a new highly doped ohmic cap layer with a sub-micron gate recess process. RF performance was further verified by CW Class-A power measurements with passive source and load tuning at 800 MHz, resulting in POUT, power gain, and power-added efficiency of 0.23 W/mm, 5.1 dB, and 6.3%, respectively. These preliminary results indicate potential for monolithic or heterogeneous integration of power switch and RF devices using β-Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> .
Experimental and computational investigation of Morse taper conometric system reliability for the definition of fixed connections between dental implants and prostheses (2014)

Nowadays, dental implantology is a reliable technique for treatment of partially and completely edentulous patients. The achievement of stable dentition is ensured by implant-supported fixed dental prostheses. Morse taper conometric system may provide fixed retention between implants and dental prostheses. The aim of this study was to investigate retentive performance and mechanical strength of a Morse taper conometric system used as implant-supported fixed dental prostheses retention. Experimental and finite element investigations were performed. Experimental tests were achieved on a specific abutment-coping system, accounting for both cemented and non-cemented situations. The results from the experimental activities were processed to identify the mechanical behavior of the coping-abutment interface. Finally, the achieved information was applied to develop reliable finite element models of different abutment-coping systems. The analyses were developed accounting for different geometrical conformations of the abutment-coping system, such as different taper angle. The results showed that activation process, occurred through a suitable insertion force, could provide retentive performances equal to a cemented system without compromising the mechanical functionality of the system. These findings suggest that Morse taper conometrical system can provide a fixed connection between implants and dental prostheses if proper insertion force is applied. Activation process does not compromise the mechanical functionality of the system.
Allosteric modulation of adenosine A<sub>1</sub> receptor coupling to G‐proteins in brain (2005)

2-Amino-4,5,6,7-tetrahydrobenzo(beta)thiophen-3-yl 4-chlorophenylmethanone (T62) is a member of a group of allosteric modulators of adenosine A1 receptors tested in animal models of neuropathic pain to increase the efficacy of adenosine. To determine its mechanisms at the level of receptor-G-protein activation, the present studies examined the effect of T62 on A1-stimulated [35S]guanosine-5'-O-(gamma-thio)-triphosphate ([35S]GTPgammaS) binding in brain membranes, and by [35S]GTPgammaS autoradiography using the A1 agonist, phenylisopropyladenosine (PIA), to activate G-proteins. In hippocampal membranes, T62 increased both basal and PIA-stimulated [35S]GTPgammaS binding. The effect of T62 was non-competitive in nature, since it increased the maximal effect of PIA, with no effect on agonist potency. GTPgammaS saturation analysis showed that T62 increased the number of G-proteins activated by agonist but had no effect on the affinity of activated G-proteins for GTPgammaS. [35S]GTPgammaS autoradiography showed that the neuroanatomical localization of T62-stimulated [35S]GTPgammaS binding was identical to that of PIA-stimulated activity. The increase in PIA-stimulated activity by T62 varied between brain regions, with areas of lower A1 activation producing the largest percent modulation by T62. These results suggest a mechanism of allosteric modulators to increase the number of activated G-proteins per receptor, and provide a neuroanatomical basis for understanding potential therapeutic effects of such drugs.
A Multilevel, Control-Theoretic Framework for Integration of Planning, Scheduling, and Rescheduling (2005)

In this paper, an integrated multilevel, control-theoretic framework has been proposed for effectively handling integration of planning, scheduling, and rescheduling. A general resource-constrained, multistage, multiproduct plant operating as a hybrid flowshop facility has been considered. The proposed approach is based on the inherent hierarchical decomposition of the overall decision-making process that is a typical characteristic of large enterprises. The overall problem is segregated into three levels with different horizons, wherein planning over multiperiods is at the top level followed by scheduling for a single period at the middle level and a detailed inventory management schedule for the operator at the lower level. In the hierarchical decomposition, the upper levels are equipped with abstractions of the lower levels and proactiveness for reactive scheduling. The integration of reactive scheduling is motivated by some of the process control principles like cascade control and the concepts of receding horizon. Using the philosophy of decentralized decision-making, it is demonstrated that the lower levels with accurate models have the flexibility and amenability for rescheduling without upsetting the global performance. As an illustrative case study, cyclic scheduling of a simple refinery flow sheet involving continuous lube production in a resource constrained hybrid flowshop is presented to demonstrate the proposed methodology.
Beam steering in GaInAs/GaAs slow-light Bragg reflector waveguide amplifier (2011)

A high-resolution beam steering technique was proposed with a slow-light Bragg reflector waveguide amplifier. By tuning the wavelength of the propagating slow-light mode, a giant change in a deflection angle is predicted and high-resolution beam steering is prospective. In this paper, the first experimental demonstration of the beam steering technique is presented. We demonstrated a continuous beam steering of over 30°. The deflection angles are in good agreement with simulation results. By injecting larger current, the effective radiation window length is increased and sharp divergence angle is obtained, exhibiting a potential in getting a large number of resolution points.
[Bis(diisopropylamino)phosphino]trimethylsilylcarbene: A Stable Nucleophilic Carbene (1989)

R2P̈-C̈-X or R2P⊕  C⊖-X or R2PC-X—which form best describes the activity of the title compound 1? On the basis of its reactions with Me3SiCl, Me3SiN3 and DMSO as well as NMR data, 1 was hitherto regarded as a species with PC multibonding. That 1 is rather a carbene, could now be deduced, inter alia, from the addition of electron deficient alkenes (→2) and tert-butyl isocyanide (→3) (R=iPr2N, X = SiMe3).
Quench Detection Criteria for YBa2Cu3O7‐δ Coils Monitored via a Distributed Temperature Sensor for 77 K Cases (2018)

Distributed temperature sensing (DTS), such as Rayleigh-scattering interrogated optical fiber (RIOF) sensing, is a promising method for detecting quenches in high-temperature superconductor (HTS) magnets. One key for the successful implementation of RIOF-based DTS for quench detection is to identify effective quench detection criteria for the onset of a quench. In this paper, two DTS-based quench detection criteria, and their dependence on the operating current and heat disturbance characteristics, are investigated through numerical simulations of quench behavior in a YBa <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7-δ</sub> (YBCO) HTS helix coil cooled by a liquid nitrogen (LN <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) bath and a YBCO HTS pancake coil cooled by conduction at 77 K. One is based on the minimum propagation zone (MPZ). The reference temperature to define the MPZ size is found for different operating currents. The other is based on the equilibrium temperature profile, in which the peak temperature and a characteristic normal zone length are found from a preselected reference temperature. The advantages and disadvantages of the two quench detection criterions are discussed and compared. Simulation results show that both criteria are independent of the nature of unpredictable heat disturbances. Similar to the helix coil, equilibrium temperature profiles independent of unpredictable disturbances are found for the pancake coil with different operating currents.
Organising for Business Intelligence: A Framework for Aligning the Use and Development of Information (2007)

Organisations invest in Business Intelligence systems to improve their performance, provide management information and support decision-making. In practice however, Business Intelligence can be ineffective. While Business Intelligence software enables company-wide reporting, problems are encountered in the fit between systemsâ provision and changing requirements of a growing amount of users. To contribute to the solution of these problems, a framework is defined to align the use and development of information for Business Intelligence. This framework has been validated using four explorative case studies of larger organisations.
Parameter design methodology for chemical processes using a simulator (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTParameter design methodology for chemical processes using a simulatorUrmila M. Diwekar and Edward S. RubinCite this: Ind. Eng. Chem. Res. 1994, 33, 2, 292–298Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ie00026a018https://doi.org/10.1021/ie00026a018research-articleACS PublicationsRequest reuse permissionsArticle Views161Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integration of an Insertion-Type Transferred DNA Vector from <i>Agrobacterium tumefaciens</i> into the <i>Saccharomyces cerevisiae</i> Genome by Gap Repair (1996)

Recently, it was shown that Agrobacterium tumefaciens can transfer transferred DNA (T-DNA) to Saccharomyces cerevisiae and that this T-DNA, when used as a replacement vector, is integrated via homologous recombination into the yeast genome. To test whether T-DNA can be a suitable substrate for integration via the gap repair mechanism as well, a model system developed for detection of homologous recombination events in plants was transferred to S. cerevisiae. Analysis of the yeast transformants revealed that an insertion type T-DNA vector can indeed be integrated via gap repair. Interestingly, the transformation frequency and the type of recombination events turned out to depend strongly on the orientation of the insert between the borders in such an insertion type T-DNA vector.
A multimode antenna having equal&lt;tex&gt;E&lt;/tex&gt;- and&lt;tex&gt;H&lt;/tex&gt;-planes (1975)

An antenna is described which utilizes two propagating modes in a circular waveguide. These modes are the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM_{11}</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TE_{11}</tex> , which are complementary. The phase and amplitude is adjusted at the aperture so that both modes are in phase and of equal amplitudes. The resulting pattern is circularly symmetric having equal <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</tex> - and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</tex> -patterns with extremely low back radiation.
A comparative study of the hemostatic effects of two monophasic oral contraceptives containing 30 mu(g) ethinylestradiol and either 2 mg chlormadinone acetate or 150 mu(g) desogestrel. (1999)

Our results demonstrate that both oral contraceptive preparations have comparable effects on the hemostatic system. There was a shift towards a new equilibrium of hemostatic activities, both coagulatory and fibrinolytic, at a higher turnover rate. Changes did not exceed the range of normal variation and were comparable to the published effects of other low-dose oral contraceptives. There was no evidence ofa differential risk of deep vein thrombosis between the two preparations.
Acquired <i>TNFRSF14</i> Mutations in Follicular Lymphoma Are Associated with Worse Prognosis (2010)

Clinical correlative studies have linked 1p36 deletions with worse prognosis in follicular lymphoma (FL). In this study, we sought to identify the critical gene(s) in this region that is responsible for conferring inferior prognosis. BAC array technology applied to 141 FL specimens detected a minimum region of deletion (MRD) of ∼97 kb within 1p36.32 in 20% of these cases. Frequent single-nucleotide polymorphism-detected copy-neutral loss of heterozygosity was also found in this region. Analysis of promoter CpGs in the MRD did not reveal differential patterns of DNA methylation in samples that differed in 1p36 status. Exon sequencing of MRD genes identified somatic alterations in the TNFRSF14 gene in 3 of 11 selected cases with matching normal DNA. An expanded cohort consisting of 251 specimens identified 46 cases (18.3%) with nonsynonymous mutations affecting TNFRSF14. Overall survival (OS) and disease-specific survival (DSS) were associated with the presence of TNFRSF14 mutation in patients whose overall treatment included rituximab. We further showed that inferior OS and DSS were most pronounced in patients whose lymphomas contained both TNFRSF14 mutations and 1p36 deletions after adjustment for the International Prognostic Index [hazard ratios of 3.65 (95% confidence interval, 1.35-9.878, P=0.011) and 3.19 (95% confidence interval, 1.06-9.57, P=0.039), respectively]. Our findings identify TNFRSF14 as a candidate gene associated with a subset of FL, based on frequent occurrence of acquired mutations and their correlation with inferior clinical outcomes.
Assessment of eotaxin 1 in exhaled breath condensate of chronic obstructive pulmonary disease patients (2013)

The aim of this work was to assess eotaxin 1 level in exhaled breath condensate of exacerbated and stable COPD patients in relation to normal subjects. Subjects and methods: There were 16 COPD patients (during infective exacerbation), 16 stable COPD patients and 20 healthy volunteers as controls matched with them in age, sex and smoking history. EBC was collected and concentration of eotaxin 1 was measured by using Human Eotaxin 1 ELISA Kits. Results: The mean eotaxin 1 concentration in exhaled breath condensate of studied groups was 962.5 ± 150 pg/ml in the exacerbated COPD group, 427.8 ± 186.6 pg/ml in the stable group and 89.2 ± 47.5 pg/ml in the control group. Age, smoking, FVC, FEV1, and FEV1/FVC, showed no significant correlation with eotaxin 1 levels among all the studied groups. Conclusion: Eotaxin 1 levels in exhaled breath condensate of COPD patients during infective exacerbation was significantly higher than in stable COPD patients and both groups showed significant higher levels than the control group.
Surface reconstruction from photometric stereo images (1993)

In previous research (Tech. Rep. 172, University of Southern California, Los Angeles, Calif., 1991) we developed an iterative shape-from-shading (SFS) algorithm that uses a single image, by combining a triangular-element surface model with a linearized reflectance map. In the current research we generalize the single-image SFS algorithm to the photometric stereo SFS algorithm, which uses multiple images taken under different lighting condition for more-accurate surface reconstruction. An explicit surface model based on nodal basis-function representation is used so that the integrability problem that arises in conventional photometric stereo SFS algorithms can be solved easily. It is also shown that single-image SFS algorithms have an inherent problem; i.e., the accuracy of the reconstructed surface height is related to the slope of the reflectance-map function defined on the gradient space. The accuracy can be greatly improved by combining two photometric images properly, and the optimal illumination condition that leads to the best shape reconstruction is examined. Simulation results for several test images are given to demonstrate the performance of our new algorithm.
Immediate Splenectomy Decreases Mortality and Improves Cognitive Function of Rats After Severe Traumatic Brain Injury (2011)

Our study demonstrates that splenectomy has a protective effect on rats with severe TBI by inhibiting proinflammatory cytokines, including IL-1β, TNF-α, and IL-6, both systematically and locally in the injured brain, hence leading to a decreased mortality and improved cognitive function.
Alpaca: Compact Network Policies With Attribute-Encoded Addresses (2017)

In enterprise networks, policies (e.g., QoS or security) are often defined based on the categorization of hosts along dimensions, such as the organizational role of the host (faculty versus student) and department (engineering versus sales). While current best practices (virtual local area networks) help when hosts are categorized along a single dimension, policy may often need to be expressed along multiple orthogonal dimensions. In this paper, we make three contributions. First, we argue for attribute-encoded IPs (ACIPs), where the IP address allocation process in enterprises considers attributes of a host along all policy dimensions. ACIPs enable flexible policy specification in a manner that may not otherwise be feasible owing to the limited size of switch rule-tables. Second, we present Alpaca, algorithms for realizing ACIPs under practical constraints of limited-length IP addresses. Our algorithms can be applied to different switch architectures, and we provide bounds on their performance. Third, we demonstrate the importance and viability of ACIPs on data collected from real campus networks.
Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice (2017)

Zika virus (ZIKV) has become a global public health emergency due to its rapidly expanding range and its ability to cause severe congenital defects such as microcephaly. However, there are no FDA-approved therapies or vaccines against ZIKV infection. Through our screening of viral entry inhibitors, we found that chloroquine (CQ), a commonly used antimalarial and a FDA-approved drug that has also been repurposed against other pathogens, could significantly inhibit ZIKV infection in vitro, by blocking virus internalization. We also demonstrated that CQ attenuates ZIKV-associated morbidity and mortality in mice. Finally, we proved that CQ protects fetal mice from microcephaly caused by ZIKV infection. Our methodology of focusing on previously identified antivirals in screens for effectiveness against ZIKV proved to be a rapid and efficient means of discovering new ZIKV therapeutics. Selecting drugs that were previously FDA-approved, such as CQ, also improves the likelihood that they may more quickly reach stages of clinical testing and use by the public.