gebhart/patrepeval huggingface dataset:
Ability of human T lymphocytes to adhere to vascular endothelial cells and to augment endothelial permeability to macromolecules is linked to their state of post-thymic maturation. (1990)

The accumulation of mononuclear cells at sites of chronic inflammation is dependent on a number of factors including localized adherence of lymphocytes to vascular endothelial cells (EC), cytokine-mediated increased adhesiveness of endothelium, chemotactic factors and endothelial permeability. The present study investigates two of the above attributes of lymphocyte-EC interaction: namely, the ability of maturationally distinct subpopulations of human T lymphocytes to adhere to vascular EC and to increase vascular endothelial permeability to macromolecules in an in vitro model. Thus, human T lymphocytes were separated into CD4+ CD8-helper/inducer, CD4- CD8+ cytotoxic/suppressor, CD29+ CD45RA- CD45RO+ memory, and CD29- CD45RA+ CD45RO- naive/virgin T subpopulations, were activated with PHA and PMA, and then examined for their adherence to EC and also for their effect on endothelial permeability. Upon activation, cells within each of the above four subpopulations exhibited increased adherence to EC. In contrast, resting CD29+ CD45RA- CD45RO+ memory T lymphocytes exhibited two to three times greater ability to adhere to EC than their CD29- CD45RA+ CD45RO- naive/virgin counterparts. Consistent with their increased adherence to EC, CD29+ CD45RO+ memory T lymphocytes, when activated, significantly increased endothelial permeability to albumin. Although activated CD45RA+ naive T lymphocytes exhibited increased adherence to EC, these cells failed to increase significantly endothelial permeability. Similar to their polyclonal counterparts, Ag-specific CD4+ CD29+ CD45RO+ T cell clones, but not their actively released mediators, also increased endothelial permeability via a noncytolytic mechanism(s). This ability of CD29+ CD45RO+ memory T lymphocytes to augment endothelial permeability may facilitate their transendothelial migration into extravascular space. These observations may provide additional insights into molecular mechanism(s) underlying pathophysiology of localized chronic inflammatory responses in general and more specifically selective accumulation of CD29+/CD45RO+ memory T lymphocytes at sites of chronic inflammation such as rheumatoid synovium.
U.S. PERSPECTIVE (1994)

This paper presents the current operations of Viking Freight, a less-than-truckload carrier operating on the West coast. The representative from Viking notes that they are not operating in Mexico and do not plan on doing so in the future. They are working with both interlines and agents, and will continue to do so. The author describes how the company worked up to serving Eureka, when the interlines and agents could no longer accommodate their needs. The main problem he foresees with Mexican trade is not the language, but the availability of data networks in Mexico. They are currently nonexistent, though he expects this to change in the future. He specifically needs TCP/IP networks and telephone network system data lines in order to fax shipment information to his customers.
Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. (1975)

Post-mortem specimens of the human lumbar (L4-L5) intervertebral disc have been studied histologically and physico-chemically. Blood vessels were found only at the margin of the anulus fibrosus and in the vertebral marrow spaces. Contact between disc tissue and marrow spaces occupied about 10% of the bone-cartilage interface. The disc was most cellular at the periphery of the anulus fibrosus and in the hyaline cartilage next to the vertebral bone. Cellularity declined towards the nucleus pulposus where it achieved a low constant value. The cell density of the disc as a whole was about 60000 cells/mm3. For glucose, the diffusion coefficient of the anulus fibrosus and hyaline cartilage end plate was 2.5 cm2/sec and 2.4 cm2/sec respectively at 37 degrees C, comparable to that of cartilage elsewhere. The permeability of the bone-cartilage interface was low, particularly in the peripheral part. Calculations, based on the present findings and derived values for glucose utilization in disc tissue, indicate that nutritional conditions in the intervertebral disc are more critical than, for example, in articular cartilage.
Robust one-shot 3D scanning using loopy belief propagation (2010)

A structured-light technique can greatly simplify the problem of shape recovery from images. There are currently two main research challenges in design of such techniques. One is handling complicated scenes involving texture, occlusions, shadows, sharp discontinuities, and in some cases even dynamic change; and the other is speeding up the acquisition process by requiring small number of images and computationally less demanding algorithms. This paper presents a “one-shot” variant of such techniques to tackle the aforementioned challenges. It works by projecting a static grid pattern onto the scene and identifying the correspondence between grid stripes and the camera image. The correspondence problem is formulated using a novel graphical model and solved efficiently using loopy belief propagation. Unlike prior approaches, the proposed approach uses non-deterministic geometric constraints, thereby can handle spurious connections of stripe images. The effectiveness of the proposed approach is verified on a variety of complicated real scenes.
Germ-line-derived hinge domain p53 mutants have lost apoptotic but not cell cycle arrest functions. (1998)

The protein p53 is a critical tumor suppressor, as demonstrated by its frequent mutation in human cancers. Overexpression of the wild-type form of the p53 tumor suppressor gene in human cancer cell lines has been shown to lead to either cell cycle arrest or apoptosis. A study of two Li-Fraumeni syndrome-derived p53 hinge domain mutants shows that both mutants retain the ability to arrest cell growth but are significantly impaired for the induction of apoptosis in human p53-null cell lines. This indicates that the hinge domain may be important in the regulation of p53-dependent apoptosis.
Collapsed Reticular Network and its Possible Mechanism during the Initiation and/or Progression of Hepatic Fibrosis (2016)

Among the researches on hepatic fibrosis, great attention was paid to both hepatocytes and extracellular matrix (ECM). However, little focus was drawn on reticular fibrous network, which is important for demarcation and support of hepatocytes. The aim of this study was to investigate the change pattern of reticular fibers in hepatic fibrosis/cirrhosis and its underlying mechanism. In this study, thioacetamide (TAA) and bile duct ligation (BDL) were utilized to induce rat hepatic fibrosis respectively, and Human liver cirrhotic microassay was analyzed with IHC to confirm the results in animal experiment and to detect the metalloproteinases (MMPs) expressions. As a result, the reticular fibers decreased markedly after 1 week in TAA and 1 day in BDL treated rats. Multiple representative regulators of MMPs and MMPs increased significantly in their expressions and activities. Further more, in human liver cirrhotic microassay, MMPs expressions also showed similar patterns as that of animal experiment. In Conclusions: Degradation or collapse of reticular fibers in hepatic sinusoid can be considered as a pathological feature during the initiation and/or progression of hepatic fibrosis. Moreover, such degradation is associated with and probably caused by the over/dysregulated expression of MMPs.
Carbon-coated hierarchically porous silicon as anode material for lithium ion batteries (2014)

Silicon is one of the most promising anode materials for high energy density lithium ion batteries. However, its fast capacity decay due to volume expansion and the resultant particle pulverization hinders its commercial application. Diverse strategies have been proposed to reduce these effects. In this article, hierarchically porous silicon composite is formed by coating the porous silicon particles obtained by magnesiothermically reducing commercial diatomite. Both the void space between the silicon particles and the pores within each silicon particle are designed to accommodate the volume change of silicon in the charge and discharge processes. On the other hand, the carbon coating layer alleviates the volume change of silicon and maintain the electric contact between the particles. The carbon-coated hierarchically porous silicon composite based on this design concept shows much better cyclability than that of the bare porous silicon.
Television-The Scanning Process (1941)

This is a descriptive study of the scanning process in television. It is analyzed in terms of a two-dimensional Fourier series of terms, which are correlated to the frequency components of the transmitted electrical signal. The impairment caused to the detail in the picture by the scanning process is shown to consist of two parts: (a) a blurring of the original image, and (b) the introduction of spurious patterns not in the original picture. A discussion is given of how these influence the reproduction of detail in the vertical and horizontal directions, and their relative importance in impairing the picture. A brief discussion is also given of impairments to the over-all picture caused by the scanning process, chiefly from the intermittent nature of the process.
An augmented reality home-training system based on the mirror training and imagery approach (2013)

Mirror training and movement imagery have been demonstrated to be effective in treating several clinical conditions, such as phantom limb pain, stroke-induced hemiparesis, and complex regional pain syndrome. This article presents an augmented reality home-training system based on the mirror and imagery treatment approaches for hand training. A head-mounted display equipped with cameras captures one hand held in front of the body, mirrors this hand, and displays it in real time in a set of four different training tasks: (1) flexing fingers in a predefined sequence, (2) moving the hand into a posture fitting into a silhouette template, (3) driving a "Snake" video game with the index finger, and (4) grasping and moving a virtual ball. The system records task performance and transfers these data to a central server via the Internet, allowing monitoring of training progress. We evaluated the system by having 7 healthy participants train with it over the course of ten sessions of 15-min duration. No technical problems emerged during this time. Performance indicators showed that the system achieves a good balance between relatively easy and more challenging tasks and that participants improved significantly over the training sessions. This suggests that the system is well suited to maintain motivation in patients, especially when it is used for a prolonged period of time.
Colonic epithelial cell proliferation in responders and nonresponders to supplemental dietary calcium. (1989)

Supplemental dietary calcium decreased and normalized hyperproliferation of colonic epithelial cells in individuals in familial colon cancer kindreds, measured by rates and patterns of [3H]thymidine labeling of epithelial cells in colonic crypts. In whole colonic crypts hyperproliferation was decreased to lower levels in over one-half of the subjects individually studied during the course of the calcium supplementation regimen. The remaining familial colon cancer subjects did not show reductions in cell proliferation measured over the whole crypt. However, when their cell-labeling data were analyzed in regions of the colonic crypt, the size of the proliferative compartment decreased and contracted towards the crypt base after calcium, a pattern typical of individuals at decreased risk for colonic cancer. This contraction of the proliferative region of the crypts occurred through decreased cell labeling in the two crypt compartments closest to the luminal surface and increased cell labeling in the second crypt compartment nearest to the base of the crypt. Following in vitro exposure of colonic epithelial cells to increasing physiological amounts of calcium, cell proliferation in familial colon cancer subjects decreased uniformly and greater heterogeneity in responsiveness was observed in cells from individuals with familial polyposis.
Purification of Rts1 RepA protein and binding of the protein to mini-Rts1 DNA (1988)

RepA protein, essential for the replication of plasmid Rts1, was purified, and its binding to mini-Rts1 subregions was examined by a DNase I protection assay. RepA protected the incI and incII iterons, a region immediately upstream of the repA promoter, and a 10-base-pair region located between the most external incII iteron and a GATC box. The protection was less efficient when preheated RepA was used.
Tabletop linear accelerator for massive molecules (1995)

A simple, tabletop, linear accelerator based on low duty factor square wave pulses has been developed to accelerate very heavy molecular ions (100–10 000 a.m.u.) to energies of tens of keV. The accelerator can be added to existing mass spectrometers to improve the detection efficiency (secondary electron yield) of both positive and negatively charged clusters.
Framework for a model-based, cross-domain system interconnection in automation technology (2013)

The field of system integration features various approaches from the standardization of data structure to the development of universal exchange formats, but lacks a visualization as well as a superordinated structuring concept. Within the IMIP project a model-based system interconnection was developed that combines a star-shaped coupling architecture with a task-specific model framework. All systems of an enterprise are connected to the central data backbone via a modular interface. There the actual data exchange is carried out by the interplay of mapping and transformation engines. The information needed by them is divided task-specifically into eight model types. Together with the UML based meta-model oriented to interconnection tasks this approach shall improve usability and applicability and provide a stable basis for the integration of further research.
Amdinocillin Treatment of Catheter-Associated Bacteriuria in Rabbits (1989)

The effect of the beta-lactam antibiotic, amdinocillin, on the bacterial biofilm adherent to the Foley catheter surface, the bacterial microcolonies attached to the urinary bladder mucosa, and on planktonic bacteria in the urine was studied in a rabbit model of the closed urinary catheter drainage system. Progressively increasing the dose of antibiotic in this experimental catheter-associated urinary tract infection model first eliminated the bacterial population adherent to the bladder mucosa and then the planktonic population in the urine. The bacterial biofilm on the Foley catheter could be eradicated only by the highest dose of antibiotic (400 mg/kg). Scanning electron microscopy showed a gradual deterioration of bacterial biofilm and reduction in bacterial numbers with increasing antibiotic dosages. These data suggest that antibiotics used in short-term catheterization may reduce the serious sequelae associated with catheter-related infections by clearing the potentially dangerous bladder mucosal bacterial populations and urine planktonic bacteria.
Synthesis of Some Thioquinazolones of Interest as Potential Ataractic Agents (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Some Thioquinazolones of Interest as Potential Ataractic AgentsJohn E. McCarty, Eldon L. Haines, and Calvin A. VanderWerfCite this: J. Am. Chem. Soc. 1960, 82, 4, 964–966Publication Date (Print):February 1, 1960Publication History Published online1 May 2002Published inissue 1 February 1960https://doi.org/10.1021/ja01489a046RIGHTS & PERMISSIONSArticle Views81Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (375 KB) Get e-Alerts Get e-Alerts
An extension of the three-zone model to predict depth of tissue damage beneath Er:YAG and Ho:YAG laser excisions (1989)

Pulsed lasers such as Er:YAG and Ho:YAG with outputs at mid-infrared wavelengths emit radiation which may be transmitted by fibre to a treatment site. The thickness of soft-tissue damage beneath excisions made by these lasers is predicted using an extension to a model previously devised for CO2 laser radiation. The minimum achievable thickness occurs at a water absorption peak and at such high irradiance that heat cannot diffuse significantly compared with the radiation penetration depth. This minimum thickness is estimated to be in the order of 10 microns for the Er:YAG laser.
A novel radioactive particle tracking facility for measurement of solids motion in gas fluidized beds (1985)

Abstract Measurements of solids motion in a fluidized bed have been made in a computer‐aided particle tracking facility. A radioactive tracer particle, dynamically identical to the solid particles to be studied, was mixed with the solids in the bed. The gamma radiation from the tracer was continuously monitored by a large number of scintillation detectors located around the bed, providing information on the tracer's instantaneous location. Prudent use was made of the purposely introduced redundant distance data to achieve improved accuracy. The recognition of the existence of secondary emission due to the interaction of the primary radiation and other system materials and the subsequent devising of a scheme to mitigate its effect contribute much to the success. Results for a bed with a uniform air distributor plate show the existence of two counter‐rotating toroidal vortices whose relative sizes and strengths vary with the fluidizing velocity. Fluctuating motions at low frequencies ranging from 1.6 to 16 Hz have been observed at various locations in the bed.
Oral Streptococci and Cardiovascular Disease: Searching for the Platelet Aggregation‐Associated Protein Gene and Mechanisms of <i>Streptococcus sanguis</i>‐Induced Thrombosis (2005)

CbpA was suggested to contribute to site 2 interactions in our two-site model of platelet aggregation in response to S. sanguis. Platelet polymorphisms were suggested to contribute to the thrombogenic potential of S. sanguis.
A Thermal Wave Approach for Heat Transfer in a Nonuniform Soil (2000)

A novel thermal wave model is developed for studying heat transfer in nonuniform soils. The model, which is based on the wave‐like characteristics of periodic heat flow, discretizes the soil into sublayers. The total thermal reflection and transmission coefficients at the interfaces of those sublayers are formulated and then employed to construct the soil temperature and heat flux profiles from their values at the air–soil interface. Numerical simulations showed that the thermal wave model could predict the predictions of two exact analytic models for the temperature profiles and their derivatives.
Tissue‐engineered blood vessels with endothelial nitric oxide synthase activity (2007)

Nondegradable synthetic polymer vascular grafts used in cardiovascular surgery have shown serious shortcomings, including thrombosis, calcification, infection, and lack of growth potential. Tissue engineering of vascular grafts with autologous stem cells and biodegradable polymeric materials could solve these problems. The present study is aimed to develop a tissue-engineered vascular graft (TEVG) with functional endothelium using autologous bone marrow-derived cells (BMCs) and a hybrid biodegradable polymer scaffold. Hybrid biodegradable polymer scaffolds were fabricated from poly(lactide-co-epsilon-caprolactone) (PLCL) copolymer reinforced with poly(glycolic acid) (PGA) fibers. Canine bone marrow mononuclear cells were induced in vitro to differentiate into vascular smooth muscle cells and endothelial cells. TEVGs (internal diameter: 10 mm, length: 40 mm) were fabricated by seeding vascular cells differentiated from BMCs onto PGA/PLCL scaffolds and implanted into the abdominal aorta of bone marrow donor dogs (n = 7). Eight weeks after implantation of the TEVGs, the vascular grafts remained patent. Histological and immunohistochemical analyses of the vascular grafts retrieved at 8 weeks revealed the regeneration of endothelium and smooth muscle and the presence of collagen. Western blot analysis showed that endothelial nitric oxide synthase (eNOS) was expressed in TEVGs comparable to native abdominal aortas. This study demonstrates that vascular grafts with significant eNOS activity can be tissue-engineered with autologous BMCs and hybrid biodegradable polymer scaffolds.
Detection of gene expression pattern in the early stage after spinal cord injury by gene chip. (2003)

The expression of some genes changes significantly in the early stage after spinal cord injury, which indicates the complexity of secondary spinal cord injury.
Enhance the Drilling & Tripping Performance on Automated Rigs with fully automated performance measurement (2015)

Abstract This paper describes the development and implementation of a unique new capability to automatically measure the performance of drilling crews and Invisible Lost Time; the supporting technology service makes it possible to carry out detailed comparisons of the performance of crews across a large number of installations. This technology service uses rig sensor data to automatically generate an objective description of the drilling process using the patented “Automated Operations Recognition System” without the need of additional personnel or equipment on the rig site. This simply will help improving rig performance of drilling and tripping operations and allow benchmarking and comparison between different rigs and different crews etc. The service is used to; Analyze the drilling process at a high level of quality and detail which complements traditional morning reporting. The patented “Automatized Operations Recognition System” has the potential to significantly reduce total well time by setting standardized and objective benchmarks in order to identify non-productive or “Invisible Lost Time”, otherwise known as “ILT” and to maintain an increase in performance.Uses a well-defined set of Key Performance Indicators (KPI) to measure drilling performance accurately in order to make Invisible Lost Time visible.Compare actual performance with predefined practices, and then maintain performance-optimized procedures once they are in place.Optimize an organization’s performance through benchmarking and trend analysis using Automated Drilling Performance Measurement system. Among many of the examples presented in the paper will be one on the variation in the tripping slip to slip connection time and drilling weight to weight time of 4 wells on 3 rigs. In addition, the variation among different drilling crews on each rig which showed huge differences when comparing similar operations. The paper will also present the potential savings after implementing this initiative.