gebhart/patrepeval huggingface dataset:
The Crystal and Molecular Structure of Tetragonal Ruthenium Dioxide (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Crystal and Molecular Structure of Tetragonal Ruthenium DioxideF. A. Cotton and J. T. MagueCite this: Inorg. Chem. 1966, 5, 2, 317–318Publication Date (Print):February 1, 1966Publication History Published online1 May 2002Published inissue 1 February 1966https://pubs.acs.org/doi/10.1021/ic50036a037https://doi.org/10.1021/ic50036a037research-articleACS PublicationsRequest reuse permissionsArticle Views267Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Role of calcium in triggering rapid ultrastructural damage in muscle: a study with chemically skinned fibres (1987)

ABSTRACT Agents (A23187, caffeine) believed to raise [Ca]i in vertebrate cardiac and skeletal muscles cause rapid and characteristic subcellular damage in vitro and in vivo. By using saponin-skinned amphibian pectoris cutaneous muscle and Ca-EGTA-buffered solutions it is shown that low [Ca] consistently triggers the same rapid (2–20 min), ultrastructural damage. Electron micrographs reveal a close similarity between the damaged intact and skinned preparations, namely loss of myofilament organization, specific Z-line damage, dissolution and hypercontraction bands, characteristic mitochondrial swelling and division. Where both actin and myosin filaments were lost, an underlying cytoskeletal network frequently remained, still attached to the Z-line framework. Ca was effective in skinned preparations from 5×10−7M to 8×10−6M, within the concentration range experienced by a contracting muscle. Damage was [Ca]- and time-dependent and it is suggested that it is probably the active movement of Ca ions across key membrane sites that is critical in triggering damage of the myofilament apparatus. Strontium can substitute for Ca at higher concentrations. The action of saponin suggests that the chemically skinned cell is partially activated. Ca-triggering can be bypassed experimentally by membrane-active agents or by sulphydryl agents. Ruthenium Red and trifluoperazine indirectly cause damage in the intact cell by raising [Ca] i. Studies with saponin-skinned cells and protease inhibitors show that changes in pHi, loss of ATP, Ca-activated neutral protease, or release of lysosomal enzymes (cathepsins B, D, L or H), are not involved in characteristic rapid myofilament damage.
Presence of the Tn antigen on hematopoietic progenitors from patients with the Tn syndrome. (1985)

The Tn syndrome is an acquired clonal disorder characterized by the exposure of a normally hidden determinant, the Tn antigen, on the surface of human erythrocytes, platelets, granulocytes, and lymphocytes. Two distinct populations, Tn positive (Tn+) and Tn negative (Tn-), of mature hemopoietic cells are present in Tn patients. To determine whether the Tn antigen is already expressed on erythroid, myeloid, and pluripotent progenitors, light-density mononuclear blood cells from two patients with this syndrome were separated by fluorescent-activated cell sorting and by affinity chromatography into Tn+ and Tn- fractions, using their binding properties to Helix pomatia agglutinin (HPA). Burst-forming-unit erythroid (BFU-E), colony-forming-unit granulocyte/macrophage (CFU-GM), cells were assayed in plasma clot cultures. After 12-14 d of culture, colonies were studied by a double fluorescent labeling procedure. First, a fluorescein-conjugated HPA permitted evaluation of the presence or absence of the Tn antigen at the surface of the cells composing each colony, and second, the binding of a murine monoclonal antibody against either glycophorin A (LICR-LON-R10) or against a myeloid antigen (80H5), revealed by an indirect fluorescent procedure, was used to establish the erythroid or myeloid origin of each cell. The Tn+ fraction obtained by cell sorting gave rise to nearly 100% Tn+ colonies composed exclusively of cells bearing this antigen. The reverse was observed for the Tn- cell fraction. These results demonstrate that in the Tn syndrome, BFU-E, CFU-GM, and CFU-GEMM of the Tn+ clone express the Tn antigen at this early stage of differentiation.
Recent Developments in the Molecular Characterization of Barrett’s Esophagus (1998)

Barrett's esophagus, or specialized intestinal metaplasia, is a common condition associated with gastroesophageal reflux and an increased risk for adenocarcinoma of the esophagus and gastric cardia. Currently, clinical surveillance for early detection of adenocarcinoma relies on the histopathological assessment of dysplasia. In this review we present data from the published literature, and combine this with results from our own research, to address what is currently known about the environmental factors and the molecular changes thought to be important in the pathogenesis of Barrett's esophagus. The most important and well-characterized molecular changes, preceding the development of dysplasia, are alterations in the p53 and erbB-2 genes and aneuploidy. These molecular changes, as well as environmental influences, such as the quality and quantity of gastroduodenal refluxate, may result in abnormal cell proliferation which in turn promotes further genetic abnormalities and deregulation of cell growth. The identification of molecular changes, in the context of predisposing environmental factors, will enhance our understanding of the malignant progression of Barrett's esophagus leading to more effective surveillance and treatment.
Regulation of colony-stimulating activity production. Interactions of fibroblasts, mononuclear phagocytes, and lactoferrin. (1983)

Neonatal skin fibroblasts were cultured in supernatants of peripheral blood monocytes that had been cultured with and without lactoferrin. Granulocyte-monocyte colony-stimulating activity (CSA) was measured in supernatants of the fibroblast cultures with normal T lymphocyte-depleted, phagocyte-depleted, low density bone marrow target cells in colony growth (colony-forming unit granulocyte/macrophage) assays. Monocyte-conditioned medium contained a nondialyzable factor that enhanced by 17-50-fold the production of CSA by fibroblasts. The addition of lactoferrin to monocyte cultures reduced the activity of this monokine by 75-100%. Lactoferrin did not inhibit CSA production by monokine-stimulated fibroblasts. We conclude that under appropriate conditions human fibroblasts are potent sources of CSA, that the production of CSA by these cells is regulated by a stimulatory monokine, and that the production and or release of the monokine is inhibited by lactoferrin, a neutrophil-derived putative feedback inhibitor of granulopoiesis. We propose that the major role of mononuclear phagocytes in granulopoiesis is played not by producing CSA, but by recruiting other cells to do so, and that in the steady state, feedback regulation of neutrophil production may occur as a result of a mechanism that inhibits the recruitment phenomenon.
Building a Test Collection for Speech-Driven Web Retrieval (2003)

This paper describes a test collection (benchmark data) for retrieval systems driven by spoken queries. This collection was produced in the subtask of the NTCIR-3 Web retrieval task, which was performed in a TREC-style evaluation workshop. The search topics and document collection for the Web retrieval task were used to produce spoken queries and language models for speech recognition, respectively. We used this collection to evaluate the performance of our retrieval system. Experimental results showed that (a) the use of target documents for language modeling and (b) enhancement of the vocabulary size in speech recognition were effective in improving the system performance.
Therapeutic Exercise for Vertigo with Associated Vestibular Disequilibrium. (1991)

Vestibular dysfunction includes a wide variety of impairments of physical capacity due to vertigo and disequilibrium. The purpose of this study was to analyze the relationship between the course of recovery from vertigo and therapeutic exercises for the vestibular system.The subjects were ten patients, two with Meniere's disease, seven with benign paroxysmal positional vertigo, and one with delayed endolymphatic hydrops. The vertigo of each patient was classified according to Tokumasu's scale and body sway when seated and standing. Therapeutic exercise was performed combining visual, vestibular, and proprioceptive stimulations administered by a physical therapist.All patients showed good recovery from vertigo after repeated applications of the therapeutic exercise, and the area of body sway also decreased significantly.The knowledge obtained in the present study can be applied to the treatment of patients with disequilibrium.
Minimizing downtime in seamless migrations of mobile applications (2006)

Application migration is a key enabling technology component of mobile computing that allows rich semantics involving location awareness, trust and timeliness of information processing by moving the application where the data is. Seamlessness is one of the key properties of mobile computing and downtime must be eliminated/minimized during the migration to achieve seamlessness. But migration involves large overheads, dominant of which are the overheads due to serialization and de-serialization [1]. To achieve seamless migration, an application state could be pre-serialized during the program's execution, and upon migration, the serialized data could be transmitted and de-serialized to get the execution started. Previous approach to this problem [1] removed dead state but still suffered from large migration overheads due to serialization on-demand that could lead to an unacceptable downtime.In this work, we develop a static compiler analysis plus runtime assisted framework to decrease the migration overhead to almost zero while minimizing the degradation in the program's performance. We achieve such a goal by deciding which data to be pre-serialized through analysis, and pre-serializing the state in the program. A safe state is kept that would allow immediate migration upon the arrival of an interrupt while minimizing frequent pre-serialization. When the migration interrupt comes in, the serialized data can be transmitted directly to the destination machine. This allows an application to resume its execution at the destination machine with almost no interruption (only a small amount of non-serialized data needs to be serialized during migration). The optimization serializes the data in such a way that a maximal number of functions can execute without interruption after migration. Our experiments with multimedia applications show that the migration latency is significantly reduced leading to a small downtime. Thus, the contribution of the paper is to provide an efficient methodology to perform seamless migration while limiting the overhead.
Relevance feedback decision trees in content-based image retrieval (2000)

Significant time and effort has been devoted to finding feature representations of images in databases in order to enable content-based image retrieval (CBIR). Relevance feedback is a mechanism for improving retrieval precision over time by allowing the user to implicitly communicate to the system which of these features are relevant and which are not. We propose a relevance feedback retrieval system that, for each retrieval iteration, learns a decision tree to uncover a common thread between all images marked as relevant. This tree is then used as a model for inferring which of the unseen images the user would not likely desire. We evaluate our approach within the domain of HRCT images of the lung.
Operating room data management: improving efficiency and safety in a surgical block (2013)

The developed project gives healthcare managers, anesthesiologists and surgeons useful information to increase surgical theaters efficiency and patient safety. In difficult economic times is possible to develop something that is of some value to the patient and healthcare system too.
‘Doggy’s Got Teeth … Lots of Teeth’: Representations of children and the canine in horror film and fiction (2012)

This article examines the various ways in which representations of children and their relationships with the canine (the dog or the wolf) are portrayed in contemporary horror film and fiction. The discussion suggests how these contemporary representations are influenced by former narratives located in myth and fairy tale. Important issues concerning gender are debated, with the first part of the article interrogating representations of female children and the second part of the article interrogating representations of male children. The discussion includes close readings of several key texts, including Little Red Riding Hood, The Lost Boys, The Omen and Cujo. These readings suggest how such narratives are often symptomatic of deep-seated, and often gendered, cultural anxieties that manifest clear moral warnings. Alternatively, representations of children and the canine can be more ambiguous. While some representations seem to translate into a liberal humanist hope, or desire for, the existence of an altruistic or divine entity, a goodness that is inherent to the taming of an aberrant supernatural force, other representations might be symptomatic of the horror that is threatened by the potential unleashing of an untamable human or inhuman, natural or supernatural, madness or disease that is endemic to modern culture and society.
Characterization of pulmonary function in Duchenne Muscular Dystrophy (2015)

Decline in pulmonary function in Duchenne Muscular Dystrophy (DMD) contributes to significant morbidity and reduced longevity. Spirometry is a widely used and fairly easily performed technique to assess lung function, and in particular lung volume; however, the acceptability criteria from the American Thoracic Society (ATS) may be overly restrictive and inappropriate for patients with neuromuscular disease. We examined prospective spirometry data (Forced Vital Capacity [FVC] and peak expiratory flow [PEF]) from 60 DMD patients enrolled in a natural history cohort study (median age 10.3 years, range 5-24 years). Expiratory flow-volume curves were examined by a pulmonologist and the data were evaluated for acceptability using ATS criteria modified based on the capabilities of patients with neuromuscular disease. Data were then analyzed for change with age, ambulation status, and glucocorticoid use. At least one acceptable study was obtained in 44 subjects (73%), and 81 of the 131 studies (62%) were acceptable. The FVC and PEF showed similar relative changes in absolute values with increasing age, i.e., an increase through 10 years, relative stabilization from 10-18 years, and then a decrease at an older age. The percent predicted, FVC and PEF showed a near linear decline of approximately 5% points/year from ages 5 to 24. Surprisingly, no difference was observed in FVC or PEF by ambulation or steroid treatment. Acceptable spirometry can be performed on DMD patients over a broad range of ages. Using modified ATS criteria, curated spirometry data, excluding technically unacceptable data, may provide a more reliable means of determining change in lung function over time.
Indoor Positioning Using Spatial Power Spectrum (2006)

A simple technique to estimate the position of a given mobile source inside a building is based on the received signal strength. For this methodology to have a reasonable accuracy, radio visibility of the mobile by at least three access points is required. To reduce the number of the required access points and therefore, simplify the underlying coverage design problem, we propose a new scheme that takes into account the distribution of RF energy around the receiver. In other words, we assume that the receiver is equipped with a circular antenna with beamforming capability. In this way, the spatial spectrum of the received power can be measured by rotating the antenna beam around the 360-degree field of view. This spatial spectrum can be used by a single receiver as a mean for estimating the position of a mobile transmitter. In this paper, we investigate the feasibility of this methodology, and show the improvement achieved in the positioning accuracy
<a name="home"></a>Effects of gamma-radiation on cell growth, cycle arrest, death, and superoxide dismutase expression by DU 145 human prostate cancer cells (2006)

Gamma-irradiation (gamma-IR) is extensively used in the treatment of hormone-resistant prostate carcinoma. The objective of the present study was to investigate the effects of 60Co gamma-IR on the growth, cell cycle arrest and cell death of the human prostate cancer cell line DU 145. The viability of DU 145 cells was measured by the Trypan blue exclusion assay and the 3(4,5-dimethylthiazol-2-yl)-2,5,diphenyltetrazolium bromide test. Bromodeoxyuridine incorporation was used for the determination of cell proliferation. Cell cycle arrest and cell death were analyzed by flow cytometry. Superoxide dismutase (SOD), specifically CuZnSOD and MnSOD protein expression, after 10 Gy gamma-IR, was determined by Western immunoblotting analysis. Gamma-IR treatment had a significant (P < 0.001) antiproliferative and cytotoxic effect on DU 145 cells. Both effects were time and dose dependent. Also, the dose of gamma-IR which inhibited DNA synthesis and cell proliferation by 50% was 9.7 Gy. Furthermore, gamma-IR induced cell cycle arrest in the G2/M phase and the percentage of cells in the G2/M phase was increased from 15% (control) to 49% (IR cells), with a nonsignificant induction of apoptosis. Treatment with 10 Gy gamma-IR for 24, 48, and 72 h stimulated CuZnSOD and MnSOD protein expression in a time-dependent manner, approximately by 3- to 3.5-fold. These data suggest that CuZnSOD and MnSOD enzymes may play an important role in the gamma-IR-induced changes in DU 145 cell growth, cell cycle arrest and cell death.
Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. (1991)

A 3 alpha-hydroxy A-ring-reduced metabolite of progesterone, 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone), and one of deoxycorticosterone (DOC), 3 alpha,21-dihydroxy-5 alpha-pregnan-20- one (allotetrahydroDOC), are among the most potent known ligands of gamma-aminobutyric acid (GABA) receptors designated GABAA in the central nervous system. With specific radioimmunoassays, rapid (less than 5 min) and robust (4- to 20-fold) increases of allopregnanolone and allotetrahydroDOC were detected in the brain (cerebral cortex and hypothalamus) and in plasma of rats after exposure to ambient temperature swin stress. Neither steroid was detectable in the plasma of adrenalectomized rats either before or after swim stress. However, allopregnanolone, but not allotetrahydroDOC, was still present in the cerebral cortex (greater than 3 ng/g) after adrenalectomy. These data demonstrate the presence of allopregnanolone and allotetrahydroDOC in brain and show that acute stress results in a rapid increase of these neuroactive steroids to levels known to modulate GABAA receptor function.
Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas (2017)

The epithelial-to-mesenchymal transition (EMT) is a cell biological program that confers mesenchymal traits on carcinoma cells and drives their metastatic dissemination. It is unclear, however, whether the activation of EMT in carcinoma cells can change their susceptibility to immune attack. We demonstrate here that mammary tumor cells arising from more epithelial carcinoma cell lines expressed high levels of MHC-I, low levels of PD-L1, and contained within their stroma CD8<sup>+</sup> T cells and M1 (antitumor) macrophages. In contrast, tumors arising from more mesenchymal carcinoma cell lines exhibiting EMT markers expressed low levels of MHC-I, high levels of PD-L1, and contained within their stroma regulatory T cells, M2 (protumor) macrophages, and exhausted CD8<sup>+</sup> T cells. Moreover, the more mesenchymal carcinoma cells within a tumor retained the ability to protect their more epithelial counterparts from immune attack. Finally, epithelial tumors were more susceptible to elimination by immunotherapy than corresponding mesenchymal tumors. Our results identify immune cells and immunomodulatory markers that can be potentially targeted to enhance the susceptibility of immunosuppressive tumors to various therapeutic regimens. <i>Cancer Res; 77(15); 3982-9. ©2017 AACR</i>.
Rotating Bubble Method for the Determination of Surface and Interfacial Tensions (1942)

A new method for the measurement of surface and interfacial tensions is suggested. The two phases to be investigated are placed in a closed container which is rotated at a known speed about a horizontal axis. Under the influence of the forces of rotation and of surface tension the lighter phase will take the equilibrium shape of an elongated bubble along the axis of rotation. If the length of the bubble is made large compared to the radius, the shape of the bubble can be closely approximated by a circular cylinder with hemispherical ends. For the case of a long bubble expressions are derived for the surface tension as a function of the bubble dimensions and for the shape of the bubble end.
Allelic variations in rat MHC class II binding of myelin basic protein peptides correlate with encephalitogenicity (1999)

The impact of the strength and promiscuity of the self peptide-MHC class II interaction on susceptibility to autoimmune disease is uncertain. Here we studied allelic differences in the affinity of rat MHC class II molecules for myelin basic protein (MBP) peptides spanning from position 63 to 106. Predominantly peptides from this region are immunogenic in the rat and the MHC class II region determines if the response is disease promoting or disease protective. Strikingly, RT1.B (DQ-like) molecules showed much more allelic variation of MBP peptide binding than RT1.D (DR-like) molecules. Moderate to strong binding of particular MBP peptides correlated with their previously documented encephalitogenicity. Moreover, the differences in disease susceptibility to certain MBP peptides observed in the different rat strains were clearly reflected in the allelic diversity of the peptide binding profiles. In conclusion our findings demonstrate that disease-inducing stretches of MBP generally comprise good binding peptides.