gebhart/patrepeval huggingface dataset:
Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice (2002)

A pathological hallmark of polyglutamine diseases is the presence of inclusions or aggregates of the expanded polyglutamine protein. Polyglutamine inclusions are present in the neuronal nucleus in a number of inherited neurodegenerative disorders, including Huntington disease (HD). Recent studies suggest that polyglutamine inclusions may sequester polyglutamine-containing transcription factors and deplete their concentration in the nucleus, leading to altered gene expression. To test this hypothesis, we examined the expression and localization of the polyglutamine-containing or glutamine-rich transcription factors TBP, CBP and Sp1 in HD mouse models. All three transcription factors were diffusely distributed in the nucleus, despite the presence of abundant intranuclear inclusions. There were no differences in the nuclear staining of these transcription factors between HD and wild-type mouse brains. Although some CBP staining appeared as dots in the selective brain regions (e.g. hypothalamus and amygdala), double labeling showed that most CBP was not co-localized with huntingtin nuclear inclusions. Electron microscopy confirmed that CBP was diffusely distributed in the nucleus. Western blots showed that these transcription factors were not trapped in huntingtin inclusions. In the striatum of HD mice, which suffers a significant reduction in the expression of a number of genes, mutant huntingtin was present in both an aggregated and a diffuse form. These findings suggest that altered gene expression may result from the interactions of soluble mutant huntingtin with nuclear transcription factors, rather than from the depletion of transcription factors by nuclear inclusions.
Thin Films of Functionalized Multiwalled Carbon Nanotubes as Suitable Scaffold Materials for Stem Cells Proliferation and Bone Formation (2010)

In the field of regenerative medicine, human mesenchymal stem cells envisage extremely promising applications, due to their ability to differentiate into a wide range of connective tissue species on the basis of the substrate on which they grow. For the first time ever reported, we investigated the effects of a thin film of pegylated multiwalled carbon nanotubes spray dried onto preheated coverslips in terms of their ability to influence human mesenchymal stem cells' proliferation, morphology, and final differentiation into osteoblasts. Results clearly indicated that the homogeneous layer of functionalized nanotubes did not show any cytotoxicity and accelerated cell differentiation to a higher extent than carboxylated nanotubes or uncoated coverslips, by creating a more viable microenvironment for stem cells. Interestingly, cell differentiation occurred even in the absence of additional biochemical inducing agents, as evidenced by multiple independent criteria at the transcriptional, protein expression, and functional levels. Taken together, these findings suggest that functionalized carbon nanotubes represent a suitable scaffold toward a very selective differentiation into bone.
The Human Impact of Earthquakes: a Historical Review of Events 1980-2009 and Systematic Literature Review (2013)

Introduction. Population growth and increasing urbanization in earthquake-prone areas suggest that earthquake impacts on human populations will increase in the coming decades. Recent large earthquakes affecting large populations in Japan, Haiti, Chile and New Zealand are evidence of this trend and also illustrate significant variations in outcomes such damage and mortality levels. The objectives of this review were to describe the impact of earthquakes on human populations in terms of mortality, injury and displacement and, to the extent possible, identify risk factors associated with these outcomes. This is one of five reviews on the human impact of natural disasters. Methods. Data on the impact of earthquakes were compiled using two methods, a historical review from 1980 to mid 2009 of earthquake events from multiple databases and a systematic literature review of publications, ending in October 2012. Analysis included descriptive statistics and bivariate tests for associations between earthquake mortality and characteristics using STATA 11. Findings. From 1980 through 2009, there were a total of 372,634 deaths (range 314,634-412,599), 995,219 injuries (range: 845,345-1,145,093), and more than 61 million people affected by earthquakes, and mortality was greatest in Asia. Inconsistent reporting across data sources suggests that the numbers injured and affected are likely underestimates. Findings from a systematic review of the literature indicate that the primary cause of earthquake-related death was trauma due to building collapse and, the very young and the elderly were at increased mortality risk, while gender was not consistently associated with mortality risk. Conclusions. Strategies to mitigate the impact of future earthquakes should include improvements to the built environment and a focus on populations most vulnerable to mortality and injury.
A Discussion of Different Approaches for Managing the Timing of EOR Projects (2013)

Abstract Studies indicate that as much as 60% of the initial oil-in-place may remain after secondary recovery. At the same time, Enhanced Oil Recovery (EOR) methods are growing more cost effective, with 3% of current worldwide production now attributable to EOR. EOR projects, however, are strongly influenced by economics and long-run crude oil prices. In addition, EOR investment decisions are also heavily impacted by the timing of the switch from primary recovery to water flooding, and then later, the timing of the switch from water flooding to tertiary oil recovery. The question is what are the key approaches and decision parameters that drive the timing of these decisions? Do you design for EOR up front during concept development planning or do you wait and address EOR as a field matures? This paper will discuss the trade-offs between adopting two distinctly different approaches for making EOR switching decisions, designing EOR up front vs. implementation as the field matures. One approach embraces proactively designing for and executing EOR during the initial development of a field. The other approach bases switching decisions on the conditional indicators of the reservoir, coupled with a view toward the long-run oil price. This paper will also explore the key decision parameters that impact the choice of which EOR approach to pursue.
Rational Probe Optimization and Enhanced Detection Strategy for MicroRNAs Using Microarrays (2005)

MicroRNAs (miRNAs) are post-transcriptional regulators participating in biological processes ranging from differentiation to carcinogenesis. We developed a rational probe design algorithm and a sensitive labelling scheme for optimizing miRNA microarrays. Our microarray contains probes for all validated miRNAs from five species, with the potential for drawing on species conservation to identify novel miRNAs with homologous probes. These methods are useful for high-throughput analysis of micro RNAs from various sources, and allow analysis with limiting quantities of RNA. The system design can also be extended for use on Luminex beads or on 96-well plates in an ELISA-style assay. We optimized hybridization temperatures using sequence variations on 20 of the probes and determined that all probes distinguish wild-type from 2 nt mutations, and most probes distinguish a 1 nt mutation, producing good selectivity between closely-related small RNA sequences. Results of tissue comparisons on our microarrays reveal patterns of hybridization that agree with results from Northern blots and other methods.
Hereditary Risk of Breast and Ovarian Carcinoma: The Role of the Oncologist (1998)

The American Society of Clinical Oncology has affirmed the role of clinical oncologists in identifying and managing patients with familial cancer risk. Inherited mutations in the genes BRCA1 and BRCA2 are responsible for the majority of hereditary breast and ovarian cancers, and these mutations also increase the risk of second cancers in women already diagnosed with breast malignancy. Understanding the likelihood of breast and ovarian cancer associated with mutations in BRCA1 and BRCA2 begins with consideration of the biological basis of hereditary cancer risk. Identifying patients with hereditary risk requires documentation of appropriate family history, and recent studies have characterized criteria for identifying women most likely to have inherited mutations in these genes. Options for women with inherited mutations in BRCA1 and BRCA2 include surveillance, chemoprevention and prophylactic surgery, which must be considered separately for the management of the risk of breast cancer and of ovarian cancer. Knowledge of the hallmarks of hereditary risk, options for medical intervention, possible results of BRCA1 and BRCA2 laboratory analysis and the psychological concerns of patients about hereditary risk evaluation enables oncologists and other health care providers to effectively counsel and manage women with hereditary risk of breast and ovarian cancer.
Hierarchical Video Coding Scheme Using Mean-Separated Normalized Vector Quantization (1993)

A highly effective video coding method is proposed for application in a wide range of fields that utilize video information and in multimedia systems where data must be easily manipulated. The proposed video coding scheme is a hierarchical system that uses vector quantization and which also incorporates many of the basic coding components of the internationally standardized lowrate MPEG 1 coding system. In addition to providing the special data handling operations of MPEG 1, the new system incorporates a multiresolution hierarchical decomposition that permits the user to select a desired resolution level at the decoder. Source coding is achieved with mean-separated normalized vector quantization applied to image blocks that contain fundamental image patterns. However, instead of using separate codebooks for each of the different prediction modes of the coding system, this paper shows that it is possible for various prediction modes to share codebooks to achieve a more efficient implementation. The coding efficiency of the new system is estimated and compared with the performance of a DCT based system. Although the signal-to-noise ratio of the VQ system falls short by 0.5 to 1.2 dB, subjectively, the two coding systems give about the same performance. Methods for improving the quantitative signal-to-noise ratio performance are also considered.
Enlarged atomic force microscopy scanning scope: Novel sample-holder device with millimeter range (2007)

We propose a homemade sample-holder unit used for nanopositionning in two dimensions with a millimeter traveling range. For each displacement axis, the system includes a long range traveling stage and a piezoelectric actuator for accurate positioning. Specific electronics is integrated according to metrological considerations, enhancing the repeatability performances. The aim of this work is to demonstrate that near-field microscopy at the scale of a chip is possible. For this we chose to characterize highly integrated optical structures. For this purpose, the sample holder was integrated into an atomic force microscope. A millimeter scale topographical image demonstrates the overall performances of the combined system.
On the relation of order-statistics filters and template matching: optimal morphological pattern recognition (2000)

In this paper, we investigate methods for optimal morphological pattern recognition. The task of optimal pattern recognition is posed as a solution to a hypothesis testing problem. A minimum probability of error decision rule-maximum a posteriori filter-is sought. The classical solution to the minimum probability of error hypothesis testing problem, in the presence of independent and identically distributed noise degradation, is provided by template matching (TM). A modification of this task, seeking a solution to the minimum probability of error hypothesis testing problem, in the presence of composite (mixed) independent and identically distributed noise degradation, is demonstrated to be given by weighted composite template matching (WCTM). As a consequence of our investigation, the relationship of the order-statistics filter (OSF) and TM-in both the standard as well as the weighted and composite implementations-is established. This relationship is based on the thresholded cross-correlation representation of the OSF. The optimal order and weights of the OSF for pattern recognition are subsequently derived. An additional outcome of this representation is a fast method for the implementation of the OSF.
Mammal Decline and Recovery in Australia (1994)

Fifty percent of all the mammal species to have become extinct worldwide in the past 200 years have been lost from the Australian fauna giving Australia the worst record for mammal conservation of any country or continent. Sixteen species from a mammal fauna of 245 are believed to be extinct, 26 species now occur only as remnant populations occupying <20% of their former ranges. Offshore islands, tropical Australia, and the mesic fringe of the continent have provided refuges where mammal communities have survived relatively intact. The drier interior regions, which include cereal growing areas, intensive and extensive pastoral areas, and the little-used Triodia deserts, have lost many species. Extinctions and declines have not occurred equally throughout the Australian fauna, but have occurred at a disproportionately higher rate among medium-sized ground-dwelling mammals in the weight range 0.035–5.500 kg. Historically, conservation of mammals has concentrated on protection from hunting and trade, reservation of land as national parks and nature reserves, and faunal surveys to map distribution and abundance. These approaches have been necessary but insufficient to either stabilize the decline of endangered mammals or to promote their recovery. The past 20 years have seen many attempts to conserve endangered mammals, either by evading the presumed cause(s) of extinction or decline by translocation to islands, or by managing these causes within reserves by controlling exotic predators, controlling or excluding exotic herbivores, or applying a particular fire pattern or regime. The most significant successes have come with effective control of exotic predators, either by establishing populations of endangered species on predator-free islands or by the intensive use of 1080 poison to control exotic predators at mainland sites.
QT Interval Prolongation in Acute Myocardial Infarction (1985)

The relationship between corrected QT (QTc) interval and clinical factors in acute myocardial infarction (AMI) was studied, as well as long-term prognostic implications of QTc after AMI. QTc was measured on admission to the coronary care unit (CCU). Patients with AMI who showed ventricular fibrillation or severe ventricular tachycardia (n = 27) had prolonged QTc in comparison to AMI patients without ventricular arrhythmias (VA) and noninfarction patients. QTc was measured at discharge from hospital in 463 survivors of AMI. Patients with anterior infarcts had longer QTc than those with inferior infarcts. Patients with VA in the CCU had longer QTc. Patients who died (3-6 years) had shorter QTc; explained by digitalis therapy. Among patients (less than 66 years) without bundle branch block digitalis and quinidine, those who died within six months tended to have longer QTc than the survivors. QTc intervals were measured on the first two days in the CCU, the first post-CCU day, at discharge, and at 1-3, 6 and 12 months after discharge, in 160 AMI patients (less than 66 years). The highest QTc values were registered in the CCU, the lowest at the 1-year control. During the acute phase, patients with anterior infarcts had longer QTc than those with inferior infarcts. Those with subendocardial infarcts had longer QTc intervals. Patients who reinfarcted or died (particularly when sudden) after discharge had longer QTc during the post-CCU period; QTc at discharge was of significant independent value for predicting major cardiac events. QTc intervals were measured as in study III. Metoprolol (n = 59) or placebo (n = 52) were given prior to discharge to AMI patients (less than 70 years). QTc decreased in both groups between discharge and the 3-month control; most marked in those on beta-receptor blockade with prolonged QTc. Patients on metoprolol had shorter QTc during the follow-up. Patients who died suddenly had longer QTc prior to discharge than those without major cardiac events. In a prospective collaborative study, QTc intervals were measured at discharge from hospital in 865 patients. All patients who died after discharge within 30 days after admission were on medication or pacemaker therapy which would influence QTc. When this was taken into consideration, QTc was significantly longer in patients who died within 180 days and 1 year.(ABSTRACT TRUNCATED AT 400 WORDS)
MADM-Based Parametric Selection and Ranking of E-Learning Websites Using Fuzzy COPRAS (2018)

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Contribution:</i> The main contribution is to provide practitioners and researchers with an insight in efficiently and effectively employing multi-attribute decision making (MADM) methods in e-learning website selection problems. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Background:</i> Advances in information systems and the Internet have resulted in e-learning websites becoming an important interface for learners. The selection of a particular website directly affects the end users’ performance, with the objectives and expected outcomes of e-learning being largely dependent on the quality of the teaching processes and the effectiveness of online access. Evaluation and selection of these websites has thus become a decisive issue for learners and developers. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Intended Outcomes:</i> This paper is expected to provide decision support to leaders in education and educational organizations in effectively analyzing and managing their e-learning system. A knowledge-based system may be developed to develop and assess e-learning websites in a meaningful way. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Application Design:</i> A hybrid MADM method, fuzzy complex proportional assessment (COPRAS) is used to evaluate, rank, and select e-learning websites of “C” programming language. The fuzzy COPRAS method is validated by comparison with the technique for order preference by similarity to ideal solution, on an existing selection problem of 12 websites available in the open literature. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Findings:</i> Fuzzy COPRAS provides a comprehensive ranking of e-learning websites based on fitness degree values. The case study results rated tutorialspoint.com as the best of the e-learning websites considered, and howstuffworks.com was rated lowest. This paper shows that fuzzy COPRAS could be useful for e-learning practitioners, developers, and the researchers.
Retrospective cine <sup>3</sup>He ventilation imaging under spontaneous breathing conditions: a non‐invasive protocol for small‐animal lung function imaging (2006)

A non-invasive and free-breathing hyperpolarized (HP) (3)He imaging protocol for small animals was implemented and validated on rats for lung function imaging. Animals were allowed to breathe a mixture of air and (3)He from a mask and a gas reservoir fitted to their heads. Radial imaging sequences were used, and MRI signal intensity changes were monitored for retrospective cine image reconstruction. The ventilation cycle of the animals was imaged with a 100 ms temporal resolution. The sliding window imaging technique was applied to reconstruct 5 ms time-shifted image series covering the complete breathing cycle. Image series were processed to extract quantitative ventilation parameters such as the gas arrival time. The reproducibility and the non-invasiveness of this ventilation imaging protocol were evaluated by multiple acquisitions on the same animals.
Walsingham and Burghley in Queen Elizabeth's Privy Council (1913)

Journal Article Walsingham and Burghley in Queen Elizabeth's Privy Council Get access CONYERS READ CONYERS READ Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume XXVIII, Issue CIX, January 1913, Pages 34–58, https://doi.org/10.1093/ehr/XXVIII.CIX.34 Published: 01 January 1913
Micro‐Macroscopic Coupled Modeling of Batteries and Fuel Cells: I. Model Development (1998)

A micro-macroscopic coupled model, aimed at incorporating solid-state physics of electrode materials and interface morphology and chemistry, has been developed for advanced batteries and fuel cells. Electrochemical cells considered consist of three phases: a solid matrix (electrode material or separator), an electrolyte (liquid or solid), and a gas phase. Macroscopic conservation equations are derived separately for each phase using the volume averaging technique and are shown to contain interfacial terms which allow for the incorporation of microscopic physical phenomena such as solid-state diffusion and ohmic drop, as well as interfacial phenomena such as phase transformation, precipitation, and passivation. Constitutive relations for these interfacial terms are developed and linked to the macroscopic conservation equations for species and charge transfer. A number of nonequilibrium effects encountered in high-energy-density and high-power-density power sources are assessed. Finally, conditions for interfacial chemical and electrical equilibrium are explored and their practical implications are discussed. Simplifications of the present model to previous macrohomogeneous models are examined. In a companion paper, illustrative calculations for nickel-cadmium and nickel-metal hydride batteries are carried out. The micro-macroscopic model can be used to explore material and interfacial properties for desired cell performance.
Durango-Silverton Railway (2011)

is a sophomore Environmental Studies major with a minor in Biology.She was born in Europe and has travelled extensively with her family, and at Gettysburg College
Wave equation based internal multiple modeling in 3D (2008)

Model‐based surface related multiple modeling (3D SRMM) can be achieved by the use of pre‐stack demigration algorithms, thus avoiding the constrains on the shot positions distribution required by the data‐based methods. In the following, we show a new method for modeling internal multiples in 3D by using a model‐based technique. This method follows a parallel flow with respect to those employed by the data‐based multiple modeling techniques, and allows for the construction of internal multiple events produced between upper layers reflecting the energy downward, and lower layers reflecting the energy upward. The method has been applied to Wide Azimuth Towed Streamer data from the Gulf of Mexico.
Devitrification of High‐SiO <sub>2</sub> Glasses of the System Al <sub>2</sub> O <sub>3</sub> ‐SiO <sub>2</sub> (1959)

Pertinent works of previous investigators are reviewed briefly. A superior technique for the preparation of experimental glasses of high purity and chemical homogeneity is presented. Devitrification growth‐rate data and traction‐viscosity data are reported for high‐silica glasses of the system Al 2 O 3 ‐SiO 2 . Glasses with added Al 2 O 3 were found to devitrify to cristobalite more rapidly than ultrapure silica glasses at a given temperature, and yet their fluidities (i.e., reciprocal viscosities) were found to be less. The devitrification growth rate, g, was found to be of zero order and to follow the temperature dependence In( g/T ) = ‐(B/T) + In A over the temperature range 1561°K. T 1730°K.