gebhart/patrepeval huggingface dataset:
Identification and characterization of proteinase K-resistant proteins in members of the class Mollicutes (1991)

Proteins resistant to proteinase K are rare because of the potency, wide pH optimum, and low peptide bond specificity of this enzyme. Previously, only the prion proteins associated with transmissible spongiform encephalopathies, possibly related proteins in the mollicute Spiroplasma mirum, and proteinase K itself have been reported. We identified a new proteinase K-resistant protein, p40-pr, in two strains of Mycoplasma hyorhinis and in extracts of these organisms. p40-pr's are similar to prion proteins in their resistance to high doses of proteinase K and in the reversal of this resistance by strong denaturing conditions. However, p40-pr's were distinct immunologically, in relative molecular mass, and in their method of extraction. Two immunologically related forms of p40-pr were identified on sodium dodecyl sulfate (SDS) gels and Western immunoblots, a 40-kDa species in boiled samples and a 120-kDa species dissociable by boiling in SDS. Reduction with 2-mercaptoethanol did not affect the mass of p40-pr's or the 120-kDa forms. The development of proteinase K resistance of p40-pr correlated to age-dependent increases in organism protein-lipid ratios. p40-pr-like proteinase K-resistant proteins of 46 to 50 kDa were identified in four of eight additional species of the class Mollicutes but not in S. mirum. However, these mycoplasmal proteins did not react with antibody to the denatured 40-kDa form of M. hyorhinis p40-pr purified by electroelution. The chromatographically purified 46-kDa proteinase K-resistant protein of Mycoplasma orale was an arginine deiminase.
Differential incorporation of fatty acids into and peroxidative loss of fatty acids from phospholipids of human spermatozoa (1995)

Intact human sperm incorporated radiolabelled fatty acids into membrane phospholipids when incubated in medium containing bovine serum albumin as a fatty acid carrier. The polyunsaturated fatty acids were preferentially incorporated into the plasmalogen fraction of phospholipid. Uptake was linear with time over 2 hr; at this time sufficient label was available to determine the loss of fatty acids under conditions of spontaneous lipid peroxidation. Loss of the various phospholipid types, the loss of the various fatty acids from these phospholipids, and the overall loss of fatty acids were all first order. The loss of saturated fatty acids was slow with first order rate constant k1 = 0.003 hr-1; for the polyunsaturated fatty acids, arachidonic and docosahexaenoic acids, k1 = 0.145 and 0.162 hr-1, respectively. The rate of loss of fatty acids from the various phospholipid types was dependent on the type, with loss from phosphatidylethanolamine being the most rapid. Among the phospholipid types, phosphatidylethanolamine was lost at the greatest rate. Analysis of fatty acid loss through oxidation products was determined for radiolabelled arachidonic acid. Under conditions of spontaneous lipid peroxidation at 37 degrees C under air in the absence of albumin, free arachidonic acid was found in the medium, along with minor amounts of hydroxylated derivative. All the hydroperoxy fatty acid remained in the cells. In the presence of albumin, all the hydroperoxy fatty acid was found in the supernatant bound to albumin; none could be detected in the cells. Albumin is known as a very potent inhibitor of lipid peroxidation in sperm; its action may be explained, based on these results, as binding the damaging hydroperoxy fatty acids. These results also indicate that a phospholipase A2 may act in peroxidative defense by excising a hydroperoxy acyl group from phospholipid and providing the hydroperoxy fatty acid product as substrate to glutathione peroxidase. This formulation targets hydroperoxy fatty acid as a key intermediate in peroxidative degradation.
Correlations among Mg, Ca and P contents of digesta in the gastro-intestinal tract of rats. (1986)

Mg, Ca and P contents of feed, digesta in the gastro-intestinal tract (10 parts) and feces were determined in rats. Remarkable absorption of Ca in the upper small intestine and of Mg in the caecum were observed. Significant positive correlations were obtained between Mg vs. Ca, and also Mg vs. P contents from the feed to the digesta in the lower small intestine (p<0.001, respectively), and between Ca vs. P contents from the feed to the feces (P<0.001).
A Histologic and Immunohistochemical Study of Calcium Pyrophosphate Dihydrate Crystal Deposition Disease (1991)

The articular cartilage, synovial membrane, and meniscus from ten patients who had calcium pyrophosphate dihydrate (CPPD) crystal deposition disease showed strong immunoreactivity for dermatan sulfate proteoglycan, Type I collagen, and S-100 protein in hypertrophic chondrocytes around the crystals, their pericellular matrix, and deposits of the crystals. Electron microscopy revealed that small crystals were formed around the hypertrophic chondrocytes, especially in the degenerated matrix containing electron-dense granular materials and cellular debris. Chondrocytes of this kind were never observed in the articular tissue from ten patients who had osteoarthrosis. These hypertrophic chondrocytes with several unique immunohistochemical characteristics may initiate the formation of CPPD crystals.
Implicit Data Permutation for SIMD Devices (2009)

SIMD extension is one of the most effective ways to exploit data level parallelism in current microprocessor design. But limited by some constraints, such as memory address alignment and in consecutive memory access, data permutation operations are usually needed before SIMD calculations, which impede us to exploit more parallelism. In this paper, an implicit data permutation mechanism is proposed. With our approach, original explicit data permutation can be split into two stages: explicit pattern setting and implicit data reorganization. The first stage is performed by scalar instructions and the second one is triggered implicitly when a vector register is read. It provides new chance for further optimization. To make this mechanism programmable, several new scalar instructions are extended and corresponding compilation strategies are also proposed. Experimental results show that oriented to multimedia benchmarks, 1.18x speedup can be achieved over current SIMD optimization techniques on average.
Growth of Cu<sub>2</sub>S Ultrathin Nanowires in a Binary Surfactant Solvent (2005)

We demonstrate a facile solution-phase method for the synthesis of single-crystal, high aspect ratio, and ultrathin nanowires of hexagonal-phase Cu2S by thermal decomposition of CuS2CNEt2 in a mixed surfactant solvent of dodecanethiol and oleic acid at 160 degrees C. Cu2S nanowires can be controllably synthesized with a diameter as thin as 1.7 nm and length up to tens of micrometers; they are usually aligned in the form of bundles with a thickness of hundreds of nanometers. Based on the experimental results, the formation mechanism of the ultrathin nanowires has been properly proposed. Some key synthetic parameters, which have a significant effect on the sizes and shapes of the products, have also been investigated in detail. UV-vis spectroscopy measurement reveals that the resultant ultrathin nanowires show a strong quantum size effect.
Bootstrapping security associations for routing in mobile ad-hoc networks (2005)

To date, most solutions proposed for secure routing in mobile ad-hoc networks (MANETs), assume that secure associations between pairs of nodes can be established on-line; e.g., by a trusted third party, by distributed trust establishment. However, establishing such security associations, with or without trusted third parties, requires reliance on routing layer security. In this paper, we eliminate this apparent cyclic dependency between security services and secure routing in MANETs and show how to bootstrap security for the routing layer. We use the notion of statistically unique and cryptographically verifiable (SUCV) identifiers to implement a secure binding between IP addresses and keys that is independent of any trusted security service. We illustrate our solution with the dynamic source routing (DSR) protocol and compare it with other solutions for secure routing.
EARLY AGALACTOSYLATION OF IgG IS ASSOCIATED WITH A MORE PROGRESSIVE DISEASE COURSE IN PATIENTS WITH RHEUMATOID ARTHRITIS: RESULTS OF A FOLLOW-UP STUDY (1994)

The clinical significance of the percentage agalactosyl IgG oligosaccharides [%G(O)] was investigated in serum of a well-characterized cohort of 127 female RA patients who were followed for a mean duration of 6 yr. The %G(O) was determined in the first available serum sample which was obtained at a mean of 3.4 yr after symptom onset. It could be shown that patients with a %G(O) more than 2 S.D. above the mean level of controls (n = 34), had significantly more erosions, disease activity, and were treated with more second-line drugs, than patients without an increased %G(O) (n = 93), both at the time the serum sample was obtained, and during follow-up. These findings suggest that G(O) may serve as an indicator for the disease course in patients with RA.
Geometry Compression Of Tetrahedral Meshes Using Optimized Prediction (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
The effects of high oral magnesium supplementation on blood pressure, serum lipids and related variables in apparently healthy Japanese subjects (1997)

In a double-blind, placebo-controlled study, thirty-three subjects were allocated to undergo either a 4-week treatment with oral Mg supplementation (Mg(OH)2; 411-548 mg Mg/d) or a placebo. The urinary excretion of Mg increased significantly in both the first 2 weeks and the following 2 weeks of Mg supplementation, while the urinary Na excretion also increased significantly over the experimental period. The systolic and diastolic blood pressure values decreased significantly in the Mg group, but not in the placebo group. The urinary aldosterone excretion and packed cell volume increased significantly during the last 2 weeks of the experimental period compared with the run-in period and first 2 weeks of supplementation. There was a statistically significant positive correlation between the values for urinary noradrenaline excretion and diastolic blood pressure at the end of the supplementation period (both expressed as a percentage of the run-in value). Statistically significant increases in lecithin-cholesterol acyltransferase (EC 2.3.1.43; LCAT), HDL-cholesterol and apolipoprotein AI were also observed after Mg supplementation. A significant positive correlation was observed between the levels of LCAT and urinary Mg excretion for the experimental period (expressed as a percentage of the run-in value). The total cholesterol:HDL-cholesterol ratio decreased significantly during the last 2 weeks of Mg supplementation compared with the first 2 weeks and the run-in periods, but this did not occur in the placebo group. These results suggest that Mg supplementation may lower blood pressure through the suppression of the adrenergic activity and possible natriuresis, while also improving the serum lipids through the activation of LCAT in human subjects.
Design and analysis of aspherical multilayer imaging x-ray microscope (1991)

Considerable effort has been devoted recently to the design, analysis, fabrication, and testing of spherical Schwarzschild microscopes for soft x-ray applications in microscopy and projection lithography. The spherical Schwarzschild microscope consists of two concentric spherical mirrors configured such that the third-order spherical aberration and coma are zero. Because multilayers are used on the mirror substrates for soft x-ray applications, it is desirable to have a small number of reflecting surfaces in the microscope. In order to reduce the microscope aberrations and increase the field of view, generalized mirror surface profiles have been considered in this study for a two-mirror microscope. Based on incoherent, sine wave modulation transfer function (MTF) calculations, the object plane resolution of a 20x microscope has been analyzed as a function of the object height and numerical aperture (NA) of the primary for several spherical Schwarzschild, conic, and aspherical reflecting two-mirror microscope configurations. The ultimate resolution of an aspherical, two-mirror microscope appears to be about 200 Å when using 100-Å radiation. Better resolution can be achieved when shorter wavelength radiation is used.
Antioxidant and hepatoprotective effects ofAcathopanax senticosus (2000)

Acathopanax senticosus (Rupr. et Maxim.) Harms. is a popular folk medicine used as a nutrient for hepatitis and cancer in Taiwan. In this study, the antioxidant activity of the crude extract and the hepatoprotective activities on CCl(4)- or acetaminophen-induced toxicity in the rat liver were evaluated. Our results suggest that A. senticosus exerts some antioxidant effects. On a CCl(4)- or acetaminophen-intoxicated -model, the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were increased by CCl(4) or acetaminophen administration and reduced by treatment with the plant extract. Histological changes around the hepatic central vein were also recovered by treatments. However, treatments with larger doses of the crude extract of A. senticosus enhanced liver damage. This result suggests that even if A. senticosus had hepatoprotective activity in small doses, treatment with larger doses would possibly induce some cell toxicity.
On-chip sub-terahertz surface plasmon polariton transmission lines in CMOS (2015)

A low-loss and low-crosstalk surface-wave transmission line (T-line) is demonstrated at sub-THz in CMOS. By introducing periodical sub-wavelength structures onto the metal transmission line, surface plasmon polaritons (SPP) are excited and propagate signals via a strongly localized surface wave. Two coupled SPP T-lines and two quasi-TEM T-lines are both fabricated on-chip, each with a separation distance of 2.4 μm using standard 65 nm CMOS technology. Measurement results show that the SPP T-lines achieve wideband reflection coefficient lower than -14 dB and crosstalk ratio better than -24 dB, which is 19 dB lower on average than the traditional T-lines from 220 GHz to 325 GHz. The demonstrated compact and wideband SPP T-lines have shown great potential for future realization of highly dense on-chip sub-THz communications in CMOS.
Radiation hardened high efficiency silicon space solar cell (2002)

A silicon solar cell with AMO 19% Beginning of Life (BOL) efficiency is reported. The cell has demonstrated equal or better radiation resistance when compared to conventional silicon space solar cells. Conventional silicon space solar cell performance is generally /spl ap/14% at BOL. The Radiation Hardened High Efficiency Silicon (RHHES) cell is thinned for high specific power (watts/kilogram). The RHHES space cell provides compatibility with automatic surface mounting technology. The cells can be easily combined to provide desired power levels and voltages. The RHHES space cell is more resistant to mechanical damage due to micrometeorites. Micrometeorites which impinge upon conventional cells can crack the cell which, in turn, may cause string failure. The RHHES, operating in the same environment, can continue to function with a similar crack. The RHHES cell allows for very efficient thermal management which is essential for space cells generating higher specific power levels. The cell eliminates the need for electrical insulation layers which would otherwise increase the thermal resistance for conventional space panels. The RHHES cell can be applied to a space concentrator panel system without abandoning any of the attributes discussed. The power handling capability of the RHHES cell is approximately five times more than conventional space concentrator solar cells.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
LOAD FLOW CALCULATION METHOD FOR Icl-CONDITIONED POWER SYSTEMS. (1980)

The load flow analysis problem is formulated as a nonlinear programming problem. The evaluation function always converges to 0 if the solution exists and converges to a non-0 value if no solution exists. The new method proposed is based on the fact that the Taylor series for the power equation has only 3 terms, the third being of the same form as the first although the variables involved are different. The method is applied to a nonconvergent 11-node system and a 43-node system which is less likely to converge, and the solutions started from the flat voltages are shown not to exist.
Adapting Spoken and Visual Output for a Pedestrian Navigation System, based on given Situational Statements (2003)

As mobile devices become more and more complex, there is an increasing desire for these devices to adapt to their users. This paper identifies parameters for different input sources (user, device and environment), and the parameters of media output (speech, graphics, sound and text), that may be modified to tailor user presentation in a pedestrian navigation system. We also provide an initial insight into some of the causal relationships between our input and output parameters, with a specific focus on the effects that speech can contribute to the presentation of media output.
<i>ITPA</i> genotyping test does not improve detection of Crohn’s disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression: Table 1 (2005)

The thiopurine drugs azathioprine (AZA) and 6-mercaptopurine (6-MP) are effective for the treatment of inflammatory bowel disease (IBD) and their prescription is increasing. Haematotoxicity, which can lead to potentially life threatening bone marrow suppression, represents the most serious side effect of thiopurine therapy. It has been attributed to the accumulation of active cytotoxic metabolites of AZA/6-MP, collectively called 6-thioguanine nucleotides, resulting from a deficiency in thiopurine catabolism specifically catalysed by the thiopurine S -methyltransferase (TPMT) enzyme. Genotyping tests are now available to identify deficient and intermediate methylators who are, respectively, homozygous and heterozygous for non-functional alleles of the TPMT gene. As pointed out by Lennard in the leading article ( Gut 2002; 51 :143–6), it is clear that myelosuppression may be caused by other factors in addition to variable TPMT.

Since the identification of the molecular …
Opioid‐induced or pain relief‐reduced symptoms in advanced cancer patients? (2005)

The effects reported were often due to multiple causes. A rapid decrease in pain intensity induced by rapid opioid titration does not produce changes in weakness, nausea and vomiting, appetite. While constipation appears the most relevant problem, resistant to common symptomatic treatment, drowsiness initially produced by acute opioid dose increase and the achievement of pain relief, tends to spontaneously decrease, probably as the result of late tolerance. Improved well-being may be the late positive effect of pain relief, also influenced by the setting of home care.
Optical and structural properties of ZnO films deposited on GaAs by pulsed laser deposition (2000)

ZnO films were synthesized on GaAs substrates at different growth conditions by pulse laser deposition. High-purity (99.999%) oxygen was used as the ambient gas. The pressure of the ambient oxygen gas for ZnO film growth was varied from 20 to 50 mTorr, and the growth temperature from 300 to 450 °C. ZnO films showed very strong bound exciton peaks located between 3.37 and 3.35 eV. The full width at half maximum of the bound exciton peak is less than 5 meV. These results indicate ZnO films on GaAs substrates can be used for optical devices such as light-emitting diodes. The other significant properties of textured ZnO films on GaAs substrates are described.
Lossless compression of language model structure and word identifiers (2003)

Very large reductions in language model memory requirements have recently been reported for large vocabulary continuous speech recognition applications through the pruning and quantization of the floating-point components of the language model: the probabilities and back-off weights. In this paper that work is extended through the compression of the integer components: the word identifiers and storage structures. A novel algorithm is presented for converting ordered lists of monotonically increasing integer values (such as are commonly found in language models) into variable-bit width tree structures such that the most memory efficient configuration is obtained for each original list. By applying this new technique together with the techniques reported previously we obtain an 86% reduction in language model size to 10Mb for no increase in word error rate on the DARPA Hub4 1998 task and a 0.5% absolute increase on the Hub4 1997 task.
Performance evaluation and relevance of the CellaVision<sup>TM</sup> DM96 system in routine analysis and in patients with malignant hematological diseases (2008)

The CellaVisiontrade mark DM96 is an automated image analysis system dedicated to locating and preclassifying the various types of white blood cells in peripheral blood smears. The system also partially characterizes of the red blood cell morphology and is able to perform platelet counts. We routinely analyzed the blood samples from 440 patients with quantitative and/or qualitative abnormalities detected by the XE-2100 Sysmextrade mark. Only 2.6% of cells are not identified by DM96trade mark. After classification of the unidentified cells very good correlation coefficients are observed between DM96trade mark and manual microscopy for most hematological parameters and accuracy is judged excellent up to 98%. For most common parameters, false positive and false negative ratios are also very good. Whatever the pathology and the number of blasts on smear, all patients were positive for blast detection on DM96trade mark. The system is a useful tool for assisting in the diagnosis and classification of most acute or chronic leukemia. Automatic cell location and preclassification, along with unique cell views on the computer screen, could reduce the time spent performing differentials and make real-time collaboration between colleagues a natural part of the classification process. The workstation also provides an ergonomically correct and relaxed working environment. We suggest its use in routine analysis; the system could be very helpful for the accurate morphological diagnosis of samples from patients with malignant hematological disease.
Milestones in Leukemia Research and Therapy (1991)

As the discipline has grown and matured within recent years, books on critical caremedicine have proliferated. Several textbooks, updates, reviews, series, and handbooks are now available to practitioners of this multidisciplinary and multispecialty endeavor. Some volumes are aimed at a particular audience\p=m-\medicalintensive care, pediatric critical care, trauma, etc. However, only a few authors and editors
Lithium and its recovery from low-grade Nevada clays (1987)

From Abstract: "A detailed flowsheet, material balance, and process evaluation are presented for the limestone-gypsum roast process. In addition, lithium reserves and resources are discussed and the McDermitt clays are described."