gebhart/patrepeval huggingface dataset:
On a class of periodic scheduling problems: Models, lower bounds and heuristics (2008)

We study in this paper a generalization of the basic strictly periodic scheduling problem where two positive integer constants, associated to each task, are introduced such that to replace the usual strict period. This problem is motivated by the combat of the dengue which is one of the major tropical disease. We discuss general properties and propose two integer mathematical models of the problem considered which are compared theoretically. We also suggest a lower bound which is derived from the structure of the problem. It appears to be quickly obtained and of good quality. Three greedy algorithms are proposed to provide feasible solutions which are compared with the optimum (when it can be obtained by the use of ILOG-Cplex10.0). It is shown that for special instances greedy algorithms are optimal.
Ventilation After Supplemental Oxygen Administration at High Altitude☆ (2004)

These results show that short-duration oxygen breathing increases the subsequent ventilatory response to poikilocapnic hypoxia in altitude-acclimatized lowlanders, resulting in a transient elevation of SpO2.
<title>Moire based optical surface profiler for the minting industry</title> (1992)

An Optical Surface Profiler (OSP130) has been developed for the metrology of master tooling used in the coin stamping process. The OSP130 measure, in a non-contacting manner, the surface relief of tools ranging in diameter from 10 mm to 300 mm. Rapid measurements are performed simultaneously on a large grid of equispaced points across the surface of the tool. From the relief data, many parameters such as the location of high and low features, volume of impression, background curvatures and various diameters can be quickly evaluated. The technique used is phase-shifting moire profilometry. A white light projector illuminates a periodic transmission grating which is then imaged onto the object surface. The light pattern on the object is viewed by a high resolution TV camera connected to a computer. The grating is shifted under computer control to a number of positions and corresponding intensity images of the deformed pattern on the object surface are stored in the computer. From the intensity images a phase map, representing the deformation of the periodic grating by the surface relief, is evaluated and compared with an undeformed pattern. This results in an accurate contour map of the surface relief with an uncertainty less than 1% of the relief excursion on the object. Details of the instrument and its use at the Royal Australian Mint are presented.
Dust mite-induced asthma in cynomolgus monkeys (2004)

Animal models exhibiting high homology with humans at the genetic and pathophysiological levels will facilitate identification and validation of gene targets underlying asthma. In the present study, a nonhuman primate model of allergic asthma was developed by sensitizing cynomolgus monkeys to dust mite antigen. Sensitization elevated allergen-specific serum IgE and IgG levels, and peripheral blood mononuclear cells isolated from sensitized animals released IL-4, IL-5, and IL-10, but not IFN-gamma. Aerosolized allergen decreased dynamic compliance and induced airway inflammation and hyperresponsiveness to aerosolized histamine. Albuterol and dexamethasone inhibited the airway constriction and allergen-induced inflammation, respectively. Airway wall remodeling that included goblet cell hyperplasia, basement membrane thickening, and smooth muscle hypertrophy was particularly evident in neonatally sensitized animals. In contrast to animals sensitized as adults, neonatally sensitized animals exhibited increased sensitivity to adenosine and larger allergen-induced changes in airway resistance and dynamic compliance. These results demonstrate that sensitization of cynomolgus monkeys with dust mite induces asthmalike symptoms, some of which may be dependent on age at the time of sensitization.
The fumigant and repellent activity of aliphatic lactones against Pediculus humanus capitis (Anoplura: Pediculidae) (2006)

New alternative insecticides are necessary for the chemical control of head lice. In this study the fumigant knockdown time 50% (KT50) and repellency index (RI) of three aliphatic lactones was compared with two essential oils and DDVP, against permethrin-resistance Pediculus humanus capitis from Argentina. In the fumigant assay, none of the lactones were effective compared to the highest activity of eucalyptus (KT50 15.53 m). In the repellency test, the three lactones were equally or more effective (RI ranging from 60.50 to 76.68) than the positive control (piperonal). These lactones are promising as head lice repellents.
Pro-inflammatory cytokines in Alzheimer’s disease (2016)

Alzheimer's disease (AD), the most common progressive neurodegenerative disorder in the elderly, is clinically characterized by progressive impairment of cognitive functions, including reduced critical capacity, weakness of decision-making and problem orientation, while in the more advanced stages it is accompanied by behavioral disorders and impaired verbal ability. Neuropathological characteristics of the disease are the neurofibrillary tangles (NFT), the neuritic plaques (NP), the prominent synaptic loss and eventually the neuronal loss. The presence of inflammatory process seems to be playing important role in the progression of the disease. This process is directed by the activated glial cells and it leads to the overproduction of acute phase proteins, complement factors activation and induction of inflammatory enzyme systems. These inflammatory factors can contribute to neuronal dysfunction and cell death. Cytokines belong to the acute phase proteins, which are secreted from glial cells. They can either strengthen the inflammatory reaction or suppress it, adjusting the intensity and duration of the immune response. In the category of cytokines belong several interleukins (ILs) and various factors (TNF-α, TGF-β). Interleukins are involved in complex intercellular interactions among neurons, microglia and astrocytes, as well as intracellular signal transduction events, which are necessary to promote the inflammatory cascade characteristic of AD neuropathology. It has been observed that increased levels of pro- inflammatory cytokines, including tumor necrosis factor (TNF), interleukin 1β (IL-1β), interleukin 6 (IL-6) and interferon γ (IFN-γ), may suspend phagocytosis of amyloid Aβ in brains of patients with AD. Thus, it may interfere with the effective removal of plaque from microglia, promote astrogliosis and neural death. Normally, during immune surveillance, a balance is maintained between pro- and antiinflammatory influences. Yet, during AD, the abnormal accumulation of soluble amyloid oligomers triggers excessive release of pro inflammatory factors, such as cytokines and other acute-phase reactants, out of proportion to the regulatory components, such as IL-4, IL-10, receptor antagonists, interleukin inhibitors and others, ultimately leading to neuronal and synaptic injury and loss and cognitive decline. These changes in the brain parenchyma are often accompanied by changes in levels of these inflammatory proteins in peripheral blood. Even though literature is presenting conflicting studies, efforts are being made for the detection of cytokines in peripheral blood and association of their levels with the progression of AD. Inflammatory pathways, involving the signaling of cytokines, could be potential targets for the prevention of AD and the development of new therapies. The aim of the present work is to review studies indicating a correlation between these inflammatory agents and AD pathogenesis.
Code for Australia: A new platform that solves problems easily and cheaply (2014)

Can government be run like the Internet, permissionless and open? We believe it can - and that tech-based solutions, built quickly and cheaply, are a powerful new way to connect citizens to their governments - and their neighbours.
Halorhabdus tiamatea sp. nov., a non-pigmented, extremely halophilic archaeon from a deep-sea, hypersaline anoxic basin of the Red Sea, and emended description of the genus Halorhabdus (2008)

An extremely halophilic archaeon was isolated from a sample of the brine–sediment interface of the Shaban Deep in the northern Red Sea. Phylogenetic analysis of the 16S rRNA gene sequence revealed a close proximity to Halorhabdus utahensis (99.3 %), the sole species of the genus Halorhabdus. Strain SARL4BT formed non-pigmented colonies and showed optimum growth at 45 °C, in 27 % (w/v) NaCl and at pH 6.5–7.0. This organism utilized a few complex substrates, such as yeast extract and starch, for growth. Strain SARL4BT grew under anaerobic and microaerophilic conditions but grew extremely poorly under aerobic conditions. The ether lipids were diphytanyl derivatives. The DNA G+C content of the type strain was 61.7 mol%. On the basis of the phylogenetic data and physiological and biochemical characteristics, strain SARL4BT represents a novel species of the genus Halorhabdus, for which the name Halorhabdus tiamatea is proposed. The type strain is SARL4BT (=DSM 18392T=JCM 14471T). An emended description of the genus Halorhabdus is also proposed.
Modes of rouleaux formation of human red blood cells in polyvinylpyrrolidone and dextran solutions (1979)

The mechanics by which normal human erythrocytes join on a plastic cover slip into two cell doublets and larger aggregates of rouleaux were studied microscopically. Polyvinylpyrrolidone (PVP-360) or dextran (DX-70 or DX-110) were used as the rouleau agents. The minimum concentration of the rouleau-inducing agents required to form doublets was 1 g/L for PVP-360 and 5 g/L for the DXs. Three modes of interaction were observed in Ringer's solution with PVP or DX, cresting and flipping (involving no intercellular sliding) and a sliding mode of doublet formation (involving less gravitational work and less cellular deformation). The sliding mechanism occurred in suspensions with the lower concentrations of the rouleau agent but was also observed when geometric constraints prevented the nonsliding interaction of larger groups of cells in the higher concentrations of the rouleau agent. The technique provides a sensitive index for studying the combined effect of cellular flexibility and intercellular adhesion. Significant changes were observed for reduced membrane surface charge or reduced ionic calcium.
Bleaching of tabular Acropora corals during the winter season in a high-latitude community (Nagasaki, Japan) (2013)

Large-scale coral bleaching for specific Acropora species was observed in two areas of Nagasaki coastal waters; Nomozaki (323549.8N, 12945 27.3E) and Mie (324815.6 N, 1294349.6E), in late March 2013. These areas are located near to the north ern limit of large populations of tabular Acropora corals on the west side of Japan (i.e., East China Sea). In Nomozaki,
Opium for China: The British Connection (2000)

Abstract This chapter outlines the economic and political considerations involved in the creation of the British opium regime in Asia. It traces opium in a “cohesive trade structure” that Britons, Indians, and Chinese created through the energetic pursuit of profitable trade, and which Britain dominated, and gained the greatest advantage from. The chapter notes that a “bifurcated framework of formal colonialism and the imperialism of free trade” characterized the British presence in Asia in the nineteenth century. It explains that through the said formal colonialism, Britain was able to impose the legalization of opium in China after 1858, and thereby secure an important financial pillar of its far-flung political empire.
Synthesis of 2β‐carbomethoxy‐3β‐(4‐[<sup>76</sup>Br]bromophenyl)tropane ([<sup>76</sup>Br]β‐CBT), a pet tracer for in vivo imaging of the dopamine uptake sites (1995)

Abstract 2β‐carbomethoxy‐3β‐(4‐[ 76 Br]bromophenyl)tropane ([ 76 Br]β‐CBT) was prepared either by electrophilic substitution from the tributyl‐stannyl derivative and peracetic acid as oxidant or by nucleophilic substitution from the iodo analogue (β‐CIT) and a Cu + assisted bromodeiodination exchange. After purification by solid phase extraction and reverse phase HPLC, the chemical and radiochemical purities of [ 76 Br]β‐CBT were > 98% and the specific radioactivity was 20 GBq/μmol. Using the two labelling techniques, the radiochemical yields were 80% and 60%, respectively. From the deshalogeno compound and different oxidizing conditions, the radiolabelling yields were < 5%. In vitro competition and saturation pharmacological studies showed that [ 76 Br]β‐CBT mainly labelled the dopamine transporter and bound to a single population of sites in striatal membranes (B max = 6.5 pmol/mg protein) with an apparent dissociation constant of 2.8 nM. Biodistribution and autoradiography studies of the title compound in rats showed that 3 h post injection, the highest concentration in the brain was found in the striata (2.5% ID/g). 24 h post injection, the striatum to cerebellum radioactive concentration ratio was still 17.
A parameterized type system for race-free Java programs (2001)

This paper presents a new static type system for multithreaded programs; any well-typed program in our system is free of data races. Our type system is significantly more expressive than previous such type systems. In particular, our system lets programmers write generic code to implement a class, then create different objects of the same class that have different objects of the same class that have different protection mechanisms. This flexibility enables programmers to reduce the number of unnecessary synchronizationoperations in a program without risking data races. We also support default types which reduce the burden of writing extra type annotations. Our experience indicates that our system provides a promising approach to make multithreaded programs more reliable and efficient
Synchrotron Radiation-Assisted Silicon Film Growth by Irradiation Parallel to the Substrate (1992)

Growth of silicon films by synchrotron radiation (SR) photolysis of Si 2 H 6 is studied for temperatures below 500°C. SR is irradiated parallel to the substrate to grow silicon film over a large area and to avoid substrate heating and gas dissociation by photoelectrons. The thickness uniformity in a 2-inch wafer is over 50% while an SR cross section is about 1×10 mm. At substrate temperatures above 300°C, the hydrogen content of the film is low enough that epitaxial silicon film is successfully grown.
Effect of cholesterol and other sterols on human sperm acrosomal responsiveness (1996)

Human sperm become responsive to inducers of the acrosome reaction when they are washed free of seminal plasma and incubated in an appropriate medium. Previous work has shown that cholesterol-enriched medium prevents sperm from becoming responsive to the inducer, progesterone. Sperm that were incubated 24 hr in cholesterol-enriched medium and then treated with progesterone showed no evidence of membrane fusion, indicating that cholesterol acts at a stage before the earliest morphological change. Inhibition of acrosomal responsiveness by cholesterol was reversible. Among other sterols reported in mammalian sperm, desmosterol and cholesterol sulfate also inhibited sperm from becoming responsive, but cholesterol palmitate did not. Our results support a model in which sperm unesterified cholesterol, or a molecule in equilibrium with it, suppresses acrosomal responsiveness. Cholesterol-enriched medium also prevented sperm from becoming responsive to the calcium/proton exchanging ionophore, ionomycin, suggesting that cholesterol's effect may be, at least in part, at a point in the signal transduction pathway subsequent to the rise in intracellular-free calcium.
The importance of propagation phenomena in personal communication networks (1991)

The first generation of cellular mobile radio networks is commercially deployed in many countries. The second generation will be digital and will come into service in the early 1990s. Similar remarks can be made regarding cordless telephones networks. More advanced mobile systems are being contemplated, and the effect of mobile communications on social life will be far reaching. The author examines the broad scene and the vital role that radio propagation has in the second and higher generation mobile networks. The author commences with a set of thumb-nail sketches of the incoming digital networks. Next, the cardinal propagation phenomena and how they have affected the second generation networks are discussed. Future systems which might operate by shaping the propagation phenomenon to suit their aims are also discussed.
Tricyclo[4.4.0.03,8]decane to adamantane rearrangement (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTricyclo[4.4.0.03,8]decane to adamantane rearrangementH. W. Whitlock Jr. and M. W. SiefkenCite this: J. Am. Chem. Soc. 1968, 90, 18, 4929–4939Publication Date (Print):August 1, 1968Publication History Published online1 May 2002Published inissue 1 August 1968https://pubs.acs.org/doi/10.1021/ja01020a028https://doi.org/10.1021/ja01020a028research-articleACS PublicationsRequest reuse permissionsArticle Views664Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deletion, Methylation, and Expression of the <i>NKX3.1</i> Suppressor Gene in Primary Human Prostate Cancer (2005)

NKX3.1 is a prostate-specific homeoprotein and tumor suppressor that is affected by the loss of 8p21 in prostate cancer. In mice, Nkx3.1 haploinsufficiency results in prostatic dysplasia and complements cancer formation induced by loss of other suppressor genes. However, NKX3.1 expression can be immunohistochemically detected in most primary prostate cancers. We examined the relationship between suppressor gene haploinsufficiency, methylation, and quantitative NKX3.1 expression levels in primary prostate cancer. NKX3.1 gene copy number was assessed by microsatellite analysis, fluorescence in situ hybridization, and quantitative PCR. NKX3.1 gene methylation was determined in prostate cancer cell lines and we thereby identified potential CpG methylation sites for methylation-specific PCR analysis in tissues. We validated and then applied an internally controlled fluorescence immunomicroscopic assay for NKX3.1 protein expression in 48 primary prostate cancer specimens from radical prostatectomies. NKX3.1 loss of heterozygosity was found in 27 of 43 tissues tested. Classic CpG island methylation of the NKX3.1 gene was not found in either prostate cancer cell lines or tissues. However, in 33 of 40 samples tested, CpG sites at -921, -903, and -47 were methylated to a greater degree in malignant than in adjacent normal cells. In 43 of 48 samples, NKX3.1 protein expression was reduced from 0.34 to 0.90 compared with adjacent normal luminal epithelium (mean of all samples, 0.68; 95% confidence interval, 0.05). In 12 cases that also had high-grade prostatic intraepithelial neoplasia, NKX3.1 expression levels were similar in preinvasive and invasive cancer cells and significantly lower than adjacent normal cells. Even in the presence of allelic loss, NKX3.1 expression is reduced over a wide range in prostate cancer at the time of prostatectomy, suggesting that diverse factors influence expression. Samples with protein expression below the median level in cancer cells had both NKX3.1 deletion and selective CpG methylation.
4. Myoblasts provide safe and effective treatments for hereditary muscular dystrophies, cardiomyopathies, type 2 diabetes, solid tumors, and aging (2018)

4. Myoblasts provide safe and effective treatments for hereditary muscular dystrophies, cardiomyopathies, type 2 diabetes, solid tumors, and aging was published in Stem Cells – From Hype to Real Hope on page 71.
Advances in Natural Rubber Production (1994)

Abstract This paper will attempt to highlight the various advances made to date in the production and processing of natural rubber (NR). The commercially planted rubber tree, Hevea brasiliensis , can yield as high as 3,000 kg of rubber per hectare in contrast to the 500 kg rubber per hectare obtained from the wild Amazonian rubber trees. The high yield of commercial rubber trees is attributed to the successful breeding program, efficient development of agronomic and crop management practices and proper exploitation systems. Today, the Hevea brasiliensis trees not only contribute to the supply of world natural rubber, but also to the ever increasing demand of tropical timber. Latex extracted from the rubber tree is processed to meet the specific requirements of the consumers. In the area of processing, emphasis is on the production of NR as an industrial raw material with improved quality and consistency. Efforts are also placed on processing efficiency, optimum product mix and production of value added modified NR such as epoxidized and deproteinized NR. The processing activities also take into consideration the control of processing effluent with appropriate effluent treatments or conversion of effluent to useful materials.
Parking lot measurement with 24 GHz short range automotive radar (2015)

This paper focuses on automotive 24 GHz radar sensors used for measuring parking lots. The parking lot detection is based upon an occupancy grid featuring Dempster-Shafer theory. The grid is filled with information of static clusters measured by the sensors. Two compensating factors are introduced to improve the reconstruction of the surroundings of the vehicle. Measurement results presented at the end of the paper show that even at higher vehicle speeds it is possible to detect parking lots on the other side of the road.
Contact Line Pinning by Microfabricated Patterns: Effects of Microscale Topography (2009)

We study how the microscale topography of a solid surface affects the apparent advancing and receding angles at the contact line of a liquid drop pinned to this surface. Photolithographic methods are used to produce continuous circular polymer rings of varying cross-sectional size and shape on hydrophilic silicon wafer surfaces. Drops of water and glycerol are dispensed into the areas bounded by these rings, and critical apparent advancing and receding angles are measured and correlated with the parameters that characterize the ring cross section. For much of the examined parameter space, the apparent critical angles are independent of ring height and width and are determined primarily by the slope of the ring's sidewalls, consistent with a model by Gibbs. For ring heights below a few micrometers, the critical angles decrease below the values predicted by the sidewall slopes alone. These results provide data for calculation of hysteresis on naturally rough surfaces and demonstrate a simple method for controlling and enhancing contact line pinning on solid surfaces.
Au café (1989)

Michel, Nanou, and Emma have spent the night in a hotel in St. Emilion near Bordeaux. They are about to order breakfast—le petit déjeuner.