gebhart/patrepeval huggingface dataset:
Control of Thymidine Kinase mRNA During the Cell Cycle (1987)

To investigate the mechanism which controls the onset of DNA synthesis, we examined the regulation of thymidine kinase (TK) and its mRNA in the cell cycle. TK activity provides a useful marker for the onset of the S phase in mammalian cells. The present analysis of regulation of TK mRNA in BALB/c 3T3 cells showed that (i) the increase in TK activity depended on the availability of TK mRNA, (ii) the level of TK mRNA between G0 and S increased more than 20-fold, (iii) the rate of run-on TK transcription increased at most 2- to 4-fold between the G0 and S phases, (iv) the half-life of TK mRNA was greater than 8 to 12 h in the S and M phases and decreased as cells entered quiescence, (v) the TK mRNA increase was fully blocked by inhibition of protein synthesis by only 60%, (vi) this inhibition was completely effective for up to about 10 h following serum addition and progressively much less effective when the drugs were added later. These results suggest that the appearance of TK mRNA at the beginning of the S phase in serum-stimulated 3T3 cells is controlled not only by the rate of gene transcription but importantly also by the decreased rate of mRNA degradation. Similar mechanisms may be involved in regulation of the onset of DNA synthesis and the increase in TK mRNA since both are controlled in a manner consistent with a requirement for a labile protein.
Nano-Sn/Hard Carbon Composite as Anode Material for Lithium Ion Batteries (2009)

The tin(Sn) nano particles were embedded into the mesopores of hard carbon spherules(HCS) to form a composite anode material for lithium ion batteries.The structure of the obtained composite was characterized by X-ray diffraction(XRD) while its electrochemical performances were evaluated with galvanostatic cycling.It is found that the embedding Sn nanoparticles into porous HCS not only result in a composite material with high lithium storage capacity and capacity retention,but also increase the initial coulombic efficiency of the composite.Based on the infrared spectroscopic analysis,the enhanced initial coulombic efficiency is attributed to the inductive decomposition of the ROCO2Li species in the solid electrolyte interphase(SEI) layer by the tin nano particles in the composite.
Clinical Development of Angiogenesis Inhibitors to Vascular Endothelial Growth Factor and Its Receptors as Cancer Therapeutics (2002)

Angiogenesis, the formation of new blood vessels, is essential for both tumor growth and metastasis. Recent advances in our understanding of the molecular mechanisms underlying the angiogenesis process and its regulation have led to the discovery of a variety of pharmaceutical agents with anti-angiogenic activity. The potential application of these angiogenesis inhibitors is currently under intense clinical investigation. Compelling evidence suggests that vascular endothelial growth factor (VEGF) and its receptors play critical roles in tumor-associated angiogenesis, and that they represent potential targets for therapeutic intervention. This has been demonstrated in a variety of animal tumor models in which disabling the function of VEGF and its receptors was shown to inhibit both tumor growth and metastasis. A number of agents designed specifically for targeting VEGF and/or its receptors are being evaluated in various clinical trials in cancer patients. This review will discuss the biology of the VEGF and its receptors, the mechanisms of action as well as the current status in clinical development of antagonistic agents to VEGF and its receptors. Included in this review are antagonistic antibodies, ribozymes, immunotoxins, and synthetic small molecular inhibitors.
Frequency noise analysis of optically self-locked diode lasers (1989)

Recent progress on frequency stabilization of a diode laser emitting near 850 nm is discussed. A confocal Fabry-Perot cavity is used to feed back the beam from the diode laser and provide resonant optical stabilization of the semiconductor laser. A detailed theoretical analysis of the static and dynamic frequency noise power spectrum of the coupled cavity laser field is presented. Static-frequency noise reduction of 50-60 dB and reduction of the laser linewidth from 20 MHz to less than 4 kHz are obtained. Finally, a detailed analysis of the beat-note spectra of two optically self-locked diode lasers shows a nonLorentzian RF power spectrum.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Effect of Chain Stiffness in Lightly Crosslinked Epoxies (1993)

Abstract Three monomer pairs were used to examine the effect of increasing backbone stiffness on material properties. Bisphenol F, resorcinol, and 2,7-dihydroxynaphthalene and their diglycidyl ether analogs of increasing stiffness were chosen for ease of processing and to avoid the complicating influences of steric hindrance, polar interactions between chains, and liquid crystallinity. Oligomeric precursors were solution polymerized to insure stoichiometric imbalance-determined crosslink density. The Tg s of the Bisphenol F, resorcinol, and 2,7-dihydroxynaphthalene LXTs are 56, 67, and 105°C, respectively, by DSC. The modulus of the Bisphenol F and resorcinol LXTs are 3.04 and 3.47 GPa, respectively.
Trial in progress: A phase Ib study of AMG 510, a specific and irreversible KRAS<sup>G12C</sup> inhibitor, in combination with other anticancer therapies in patients with advanced solid tumors harboring <i>KRAS</i> p.G12C mutation (CodeBreak 101). (2020)

TPS3661 Background: Kirsten rat sarcoma viral oncogene homolog (KRAS) p.G12C mutation has been identified as a driver oncogenic mutation in several solid tumors (eg, non-small cell lung cancer [NSCLC], colorectal cancer [CRC]). Development of therapies targeting KRAS G12C has been unsuccessful. AMG 510 is a specific and irreversible small molecule inhibitor of KRAS G12C . A first-in-human clinical trial of AMG 510 monotherapy in patients with KRAS p.G12C mutant solid tumors is currently ongoing. AMG 510 in combination with additional anticancer therapies may lead to enhanced antitumor efficacy. This study is a master protocol designed to evaluate multiple investigational regimens of AMG 510 in patients with KRAS p.G12C mutant solid tumors. Here, we present two combination cohorts of AMG 510 with a mitogen-activated protein kinase kinase (MEK) inhibitor and an investigational anti-programmed cell death protein-1 (PD-1) therapy, respectively. Additional combination cohorts will be presented at the meeting. Methods: This is a phase 1b, open-label study evaluating AMG 510 in combination with a MEK inhibitor or an investigational anti-PD-1 therapy in pts with KRAS p.G12C mutant solid tumors. The dose exploration phase (part 1; n=20) will evaluate the safety and tolerability of AMG 510 in combination with the MEK inhibitor or anti-PD-1 therapy; this will be followed by a dose expansion phase (part 2; n=40) to verify the safety and tolerability profile of AMG 510 combination therapies and assess antitumor efficacy. Key eligibility criteria include locally-advanced or metastatic malignancy with KRAS p.G12C mutation identified through molecular testing and at least one or multiple lines of prior systemic therapy (eg, ≥2 for advanced/metastatic colorectal cancer). Primary endpoints include dose-limiting toxicities, treatment-emergent or -related adverse events. Secondary endpoints include pharmacokinetic parameters of combination regimens, disease control rate, duration of response, progression-free survival, and duration of stable disease (measured by computed tomography or magnetic resonance imaging and assessed per RECIST 1.1). The study began enrolling pts in December 2019 and is ongoing. For more information, please contact Amgen Medical Information: medinfo@amgen.com . Clinical trial information: NCT04185883 .
Performance of speech recognition devices: evaluating speech produced over the telephone network (2003)

A performance evaluation facility has been designed to facilitate rapid evaluation of representative speech databases on multiple ASR (automatic speech recognition) devices. The results of an evaluation session are collected and processed automatically. The performance of four ASR devices is reported: three isolated-word and one continuous-speech. Recognition accuracy per string has been tabulated, and patterns of insertion, deletion, and substitution errors are presented. On the word level, the continuous-digit recognizer performed better on continuous-digit strings than the isolated-word recognizers on the isolated-digit strings. ASR performance on the VOIS (voice-operated intercept services) database was considerably worse than performance on the TI digits. Using the VOIS database, the best performance achieved by an isolated-word device was 75.9% word accuracy. The continuous speech ASR achieved 80.7% word accuracy and 35.2% string accuracy. The lower accuracy rates on VOIS reflect the realistic conditions under which the digits were obtained. This argues for assessing ASR devices under actual applications conditions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Simple Tray for Emergency Hand Surgery (1958)

Plastic and Reconstructive Surgery and the Transplantation Bulletin: August 1958 - Volume 22 - Issue 2 - p 184
An asynchronous remote procedure call system for heterogeneous programming (2002)

The authors introduce the reliable asynchronous remote procedure call (RARPC) which is an efficient communication control mechanism to support a heterogeneous distributed programming environment. The mechanism is based on an asynchronous control algorithm which is developed for managing multi-threaded asynchronous calls in the client/server model of the heterogeneous distributed environment. A RARPC communication exchange protocol is built on IP/UDP which is supported in the 4.3 BSD UNIX operating system. The RARPC prototype system is implemented among several Sun workstations and a VAX 11/780. The authors have measured the performance of the RARPC system and compared it to the Sun's NFS/RPC. The results show that in terms of total RPC processing time, the RARPC can improve the performance up to 50% compared to Sun NFS/RPC, for a two-machine client/server model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
2(<i>S</i>)-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3(<i>S</i>)-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine (<b>1</b>):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist (1996)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXT2(S)-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3(S)-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine (1): A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor AntagonistJeffrey J. Hale, Sander G. Mills, Malcolm MacCoss, Shrenik K. Shah, Hongbo Qi, David J. Mathre, Margaret A. Cascieri, Sharon Sadowski, Catherine D. Strader, D. Euan MacIntyre, and Joseph M. MetzgerView Author Information Merck Research Laboratories, Rahway, New Jersey 07065Cite this: J. Med. Chem. 1996, 39, 9, 1760–1762Publication Date (Web):April 26, 1996Publication History Received1 September 1995Published online26 April 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jm950654whttps://doi.org/10.1021/jm950654wrapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views1229Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Antagonists,Calcium,Molecular structure,Piperidines,Receptors Get e-Alerts
Fluorine induced formation of intermetal dielectric defects (2002)

Defects were first observed on engineering test wafers during Contact Photolithography ADI (After Develop Inspection). The defects had the appearance of large white spots, which were several microns in diameter. SEM and TEM studies revealed that the defects were delaminations at the interface between the thermal oxide and the TEOS at the contact module of the wafer process. The results from defect partitioning showed the defects first appeared after high temperature BPSG anneal. It was also observed that only the first one or two wafers in a lot had defects. Chemical contamination analysis using SIMS identified high fluorine concentrations. The results showed that the fluorine concentration of the first wafer through the TEOS process was >30% higher than the rest of the wafers in the lot. Several experimental matrices were designed and conducted to quickly contain the problem, to investigate the defect mechanisms, and to eliminate the defects. It has been concluded that the fluorine outgassing from the P/sup +/ implanted area (BF/sub 2/ implant) during high temperature BPSG anneal is the major mechanism of the defect phenomena. TEOS chamber precoating has been shown to reduce the fluorine integrated concentration of the TEOS film and has eliminated the defects.
Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage (2000)

alpha(1)-Antitrypsin is the most abundant circulating protease inhibitor and the archetype of the serine protease inhibitor or serpin superfamily. Members of this family may be inactivated by point mutations that favor transition to a polymeric conformation. This polymeric conformation underlies diseases as diverse as alpha(1)-antitrypsin deficiency-related cirrhosis, thrombosis, angio-edema, and dementia. The precise structural linkage within a polymer has been the subject of much debate with evidence for reactive loop insertion into beta-sheet A or C or as strand 7A. We have used site directed cysteine mutants and fluorescence resonance energy transfer (FRET) to measure a number of distances between monomeric units in polymeric alpha(1)-antitrypsin. We have then used a combinatorial approach to compare distances determined from FRET with distances obtained from 2.9 x 10(6) different possible orientations of the alpha(1)-antitrypsin polymer. The closest matches between experimental FRET measurements and theoretical structures show conclusively that polymers of alpha(1)-antitrypsin form by insertion of the reactive loop into beta-sheet A.
Colorless monolithically integrated 120° downconverter (2013)

We numerically demonstrate colorless reception of dense wavelength division multiplexed channels in the C-band for high-order QAM (16-64 QAM) signals on a 120° monolithically integrated downconverter, based on a 2x3 MMI with calibrated analog IQ recovery. It is shown that the proposed calibrated 120° downconverter can increase up to 80 the number of coincident channels in an efficient way, exhibiting good signal dynamic range and high fabrication yield. As this downconverter makes use of the minimum number of power outputs required for perfect recovery of IQ signals, it becomes an interesting alternative to conventional 90° based downconverters.
Launch of CATV video distribution service over FTTH (1997)

This paper reports CATV Video Distribution Service which started as a trial service in July 1997 on the basis of the know-how obtained through Utilization test of CATV video transmissions. This system provides two or more communications services over a single optical fiber which reaches subscribers' homes and allows the implementation of fiber-to-the-home (FTTH) before the most of the world.
Combined perioperative plasma endoglin and VEGF-A assessment in colorectal cancer patients. (2009)

Colorectal cancer growth and spread is absolutely dependent on angiogenesis with vascular endothelial growth factor (VEGF) being the most important cytokine involved in the process. Endoglin, a membrane co-receptor for TGF-beta, has recently emerged as a sensitive index of cancer stage. There is now sufficient evidence indicating that microvessel density assessed by endoglin-immunostaining correlates with stage of colorectal cancer and patient survival. An association of a soluble form of endoglin with lymph node and distant metastases has recently been reported in two studies. Both of them used local elaborated immunoassays for endoglin assessment. The aim of our study was to determine the efficacy of plasma endoglin, assessed using a commercial kit, as a marker of tumor spread and distant metastases in colorectal cancer patients. We studied 48 colorectal cancer patients, compared with 22 healthy subjects, using ELISA. We observed that colorectal cancer patients had increased plasma VEGF-A, but not endoglin levels. However, we found an association of plasma endoglin with the stage of malignancy. Endoglin levels were increased in metastasis-positive patients when compared to both metastasis-negative patients and healthy volunteers. Plasma endoglin correlated with VEGF-A, CEA and CA19.9. Endoglin assessment in plasma does not seem useful as a maker of colorectal cancer. Our observations indicate however that it might be helpful in selecting patients with metastatic disease.
A method to study visual attention aspects of collaboration (2008)

The previous research of visual attention has mostly considered the situations in which a single person performs a task. The current eye-tracking devices and software support this research situation. Applications of eye-tracking in the research of collaborative tasks have been rare to date. We present a methodological framework of a research in which visual attention of pair programmers with a single display has been studied. We discuss the challenges of such research when conducted in real-world settings and the requirements on the eye-tracking setups. The hardware setups and software solutions to the problems of acquisition and synchronization of streams of eye-tracking data are presented. We outline the methodological questions of future visual attention research of collaborative tasks.
Recognition of rotated images by invariant Karhunen–Loeve expansion (1994)

Given an ensemble of images, we consider a method for the extraction of optimal features that are invariant under two-dimensional rotations. Our method consists of first identifying some characteristics of the optimal basis functions and then applying the Karhunen–Loeve algorithm to determine them completely. We perform a few classification experiments with the invariant features, using a neural network as a classifier. The new method is compared with the Zernike moments method.
Effect of Bupivacaine on Muscle Tissues and New Bone Formation Induced by Demineralized Bone Matrix Gelatin (1991)

Heterotopic bone formation induced by demineralized bone matrix gelatin (BMG) in bupivacaine-HCl-treated skeletal muscle was examined histologically. BMG was obtained by dehydrating diaphyseal shafts of femora and tibiae of male, 4-week-old Sprague-Dawley (SD) rats, cutting it into chips, and demineralizing and extracting the chips with various solutions. The BMG was implanted into the rectus abdominis muscle of male, 5-week-old SD rats, bupivacaine-HCl was injected at the same site, and the resulting plaques of tissues were examined histologically on days 5, 10, 15 and 20 after BMG implantation. Heterotopic bone formation occurred in all animals. The bupivacaine-treated group had more degenerated and injured muscle fibers, and more osteocytes than the control group. Electron microscopy showed that the basement membrane of muscle fibers was discontinuous and that many mononucleated cells resembling activated satellite cells were present on day 5. Many fibroblasts, undifferentiated mesenchymal cells and myogenic cells were seen in the area around the BMG. In new bones there were few osteocytes on day 10, but their numbers were increased on days 15 and 20 after implantation, especially in the bupivacaine-treated group. The population of osteocytes that increased rapidly may have included mononucleated cells similar to activated satellite cells.
Sorting Nexin 6 Enhances Lamin A Synthesis and Incorporation into the Nuclear Envelope (2014)

Nuclear lamins are important structural and functional proteins in mammalian cells, but little is known about the mechanisms and cofactors that regulate their traffic into the nucleus. Here, we demonstrate that trafficking of lamin A, but not lamin B1, and its assembly into the nuclear envelope are regulated by sorting nexin 6 (SNX6), a major component of the retromer that targets proteins and other molecules to specific subcellular locations. SNX6 interacts with lamin A in vitro and in vivo and links it to the outer surface of the endoplasmic reticulum in human and mouse cells. SNX6 transports its lamin A cargo to the nuclear envelope in a process that takes several hours. Lamin A protein levels in the nucleus augment or decrease, respectively, upon gain or loss of SNX6 function. We further show that SNX6-dependent lamin A nuclear import occurs across the nuclear pore complex via a RAN-GTP-dependent mechanism. These results identify SNX6 as a key regulator of lamin A synthesis and incorporation into the nuclear envelope.
C18:1 Methyl Ester Metathesis in [bmim][X] Type Ionic Liquids (2009)

The efficacy of [bmim][X] ionic liquids (ILs) (X = PF(6) (-), BF(4) (-) and NTf(2) (-)) as reaction media for methyl oleate metathesis was compared with that of conventional organic solvents (PhCl, PhMe, DCM and DCE) using the well-defined first and second generation Grubbs precatalysts, RuCl(2)(PCy(3))(L)(=CHPh) (L = PCy(3) or H(2)IMes). Best catalytic performance, with excellent selectivity (>98%) at moderate reaction temperatures, was achieved in [bmim][X] ILs compared to conventional solvents. The effects of anion, reaction temperature, solvent polarity, solvent viscosity, and ligand-anion interaction on the reaction are also addressed.
Anatomy, histology, and vascularity of the glenoid labrum. An anatomical study. (1992)

We studied the gross, histological, and vascular anatomy of the glenoid labrum in twenty-three fresh-frozen shoulders from cadavera to demonstrate its cross-sectional anatomy, its microvascularity, and its attachments. The superior and anterosuperior portions of the labrum are loosely attached to the glenoid, and the macro-anatomy of those portions is similar to that of the meniscus of the knee. The superior portion of the labrum also consistently inserts directly into the biceps tendon, while its inferior portion is firmly attached to the glenoid rim and appears as a fibrous, immobile extension of the articular cartilage. The arteries supplying the periphery of the glenoid labrum come from the suprascapular, circumflex scapular, and posterior circumflex humeral arteries. In general, the superior and anterosuperior parts of the labrum have less vascularity than do the posterosuperior and inferior parts, and the vascularity is limited to the periphery of the labrum. Vessels supplying the labrum originate from either capsular or periosteal vessels and not from the underlying bone.