gebhart/patrepeval huggingface dataset:
Startle modulation in children with posttraumatic stress disorder (1989)

Startle responses to bursts of white noise were recorded as blink reflexes 17-21 months after a traumatic event in six children with posttraumatic stress disorder (PTSD) and in six normal control children. A seventh child with PTSD was studied on four occasions during the 2 years following a stressful event. The startle responses were modulated by nonstartling acoustic prestimulation in order to study the inhibitory and facilitatory modulation of startle reaction by brainstem mechanisms. The children with PTSD experienced a significant loss of the normal inhibitory modulation of startle response, suggesting that the traumatic experience had induced a long-lasting brainstem dysfunction.
“Smart” Materials Based on Cellulose: A Review of the Preparations, Properties, and Applications (2013)

Cellulose is the most abundant biomass material in nature, and possesses some promising properties, such as mechanical robustness, hydrophilicity, biocompatibility, and biodegradability. Thus, cellulose has been widely applied in many fields. "Smart" materials based on cellulose have great advantages-especially their intelligent behaviors in reaction to environmental stimuli-and they can be applied to many circumstances, especially as biomaterials. This review aims to present the developments of "smart" materials based on cellulose in the last decade, including the preparations, properties, and applications of these materials. The preparations of "smart" materials based on cellulose by chemical modifications and physical incorporating/blending were reviewed. The responsiveness to pH, temperature, light, electricity, magnetic fields, and mechanical forces, <i>etc.</i> of these "smart" materials in their different forms such as copolymers, nanoparticles, gels, and membranes were also reviewed, and the applications as drug delivery systems, hydrogels, electronic active papers, sensors, shape memory materials and smart membranes, <i>etc.</i> were also described in this review.
Removing blooming artifacts with binarized deconvolution in cardiac CT (2014)

With modern CT scanners, detection and classification of coronary artery disease has become a routine applica- tion in cardiac CT. It poses a desirable non–invasive alternative to the invasive coronary angiography, which is the current clinical gold standard. However, the accuracy of cardiac CT depends on the spatial resolution of the imaging system. The limited spatial resolution leads to blooming artifacts, arising from hyper–dense calcification deposits in the arterial walls. This blooming leads to an overestimation of the degree of luminal narrowing and to loss of the morphology of the calcified region. We propose an image–based algorithm, which aims at removing the blooming and estimating the correct CT–value and morphology of the calcification. The method is based on the assumption, that each calcification consists of a compact region which has an almost constant density and attenuation. This knowledge is incorporated into an iterative deconvolution algorithm in image space. We quantitatively assess the accuracy of the proposed algorithm on analytically simulated phantom data. Qualita- tive results of clinical patient data are presented as well. In both cases, the proposed method outperforms the compared algorithms. The initial patient data results are promising. However, an ex vivo study has to be done to confirm the quantitative results of the simulation study with real specimen.
Proteome Profiling of Cancer-Associated Fibroblasts Identifies Novel Proinflammatory Signatures and Prognostic Markers for Colorectal Cancer (2013)

We have identified LTBP2, CDH11, OLFML3, and FSTL1 as selective biomarkers of cancer stroma, and CALU and CDH11 as candidate stromal biomarkers of prognostic significance in colon cancer.
Alcohol and Sexual Assault in a National Sample of College Women (1999)

Alcohol is associated with risk of sexual assault among women and with increased risk of experiencing completed rape once attacked. In particular, alcohol use prior to sexual assault by both offenders and victims may affect the severity of sexual victimization experienced by women. Little research has explored the mechanisms (e.g., social context, behavior) through which alcohol may affect outcomes of sexual attacks using multivariate analysis. This study analyzed the role of alcohol in sexual assaults experienced by a national sample of female college students. A hierarchical multivariate regression showed that victim alcohol abuse propensity and both victim and offender alcohol use prior to attack were directly associated with more severe sexual victimization to women as measured by the Sexual Experiences Survey. This study suggests that alcohol use plays both direct and indirect roles in the outcomes of sexual assaults. Rape and alcohol abuse prevention efforts can benefit from incorporating information about alcohol's role in different assault contexts.
Perceptions and Use of Anonymous Communication across Cultures (2015)

We use social networks to communicate, keep in touch and express our opinions in a manner that has become completely ubiquitous. However, this very ubiquity and ease of expression have exposed another, contentious side – one where nobody can remain completely anonymous for long and where every conversation is stored in perpetuity. Some fear that the ephemeral quality of a social interaction has been lost, which threatens our right to be forgotten and freedom of expression. In this paper, we look at why people engage in anonymous communication, and if there is a perceived need for legal protection of anonymous communication. Moreover, this paper attempts to identify cultural stratifications, if any, in the ways in which people of various cultures perceive the importance of anonymous communications. The primary cultural clusters we studied are Anglo (e.g. Australia, Canada, England, USA) and Eastern European (e.g. Albania, Bulgaria, Moldova, Russia). Our data set consists of 374 responses to our survey from people belonging to these cultures. We found that perceived freedom afforded by anonymous communication and propensity to trust are both positively related to use of anonymous communication, which in turn is positively related to perceived need for legal protection of anonymous communication. Moreover, we found that the relationship between propensity to trust and use of anonymous communication is stronger for respondents in the Eastern Europe cultural cluster than for respondents in non-Eastern Europe cultural clusters.
Computer Indexing of Electron Diffraction Patterns Including the Effects of Lattice Symmetry (1977)

In the 50 year period since the discovery of electron diffraction from crystals there has been much theoretical effort devoted to the calculation of diffracted intensities as a function of crystal thickness, orientation, and structure. However, in many applications of electron diffraction what is required is a simple identification of an unknown structure when some of the shape and orientation parameters required for intensity calculations are not known. In these circumstances an automated method is needed to solve diffraction patterns obtained near crystal zone axis directions that includes the effects of systematic absences of reflections due to lattice symmetry effects and additional reflections due to double diffraction processes. Two programs have been developed to enable relatively inexperienced microscopists to identify unknown crystals from diffraction patterns. Before indexing any given electron diffraction pattern, a set of possible crystal structures must be selected for comparison against the unknown.
Treatment of small-cell lung cancer xenografts with iodine-313-anti-neural cell adhesion molecule monoclonal antibody and evaluation of absorbed dose in tissue (1994)

Human small-cell lung cancer (SCLC) is considered a feasible target for immunotherapy using a radiolabeled monoclonal antibody (Mab). A murine Mab, NE150 (IgG1), reacts with the neural cell adhesion molecule, which is identical to cluster 1 antigen of SCLC. To estimate their therapeutic effects, NE150 and an isotype-matched control Mab were labeled with {sup 131}I and administered intravenously as a single dose into athymic mice inoculated with a NCI-H69 SCLC xenograft. The absorbed dose in organs was also examined based upon a long-term biodistribution study of {sup 131}I-NE150. Tumors initial volume 563.4 {plus_minus} 223.5 mm{sup 3} treated with 11.1 MBq (300 {mu}Ci) of {sup 131}I-NE150 diminished and became invisible at days 30-33, demonstrating a 60-day mean growth delay to reach a tripled initial volume compared with sham-treated tumors. Cumulative absorbed doses were estimated to be 2310, 410, 500, 330, and 790 cGy for the tumor, liver, kidney, spleen and lung, respectively. Iodine-131-NE150 had potent therapeutic effects against SCLC transplants in athymic mice, however, careful assessment of the side effects, improvement of radioiodination and chimerization of the Mab might be necessary to achieve efficient targeting in clinical therapeutic applications. 25 refs., 2 figs., 3 tabs.
Characterization of a new essential gene YKL619 of S. cerevisiae apparently involved in the sporulation process. (1995)

peer reviewed
Preparation, characterization, and assessment of the antiglioma effects of liposomal celastrol (2012)

The role of celastrol in the treatment of cancer has been an area of growing interest. To circumvent the issues of low solubility, poor bioavailability, and systemic toxicity of celastrol, we prepared liposomal celastrol using the thin-film dispersion method. We characterized particle size, encapsulation efficiency, and pharmacological parameters of liposomal celastrol. The drug concentration in plasma and tissues was measured using LC-MS/MS. In addition, the sulforhodamine B assay was used to determine the 50% inhibiting concentration. We assessed the effects of the compound in SHG-44 glioma subcutaneous xenografts in BALB/c nude mice. To compare the toxic effects of liposomal and free celastrol, the weight as well as hematologic, heart, liver, and kidney parameters were measured weekly and the morphology of organ tissues was observed pathologically. We found that liposomal celastrol had high encapsulation efficiency (71.67%) and liposomal celastrol had a higher C(max) and area under the curve, longer t(1/2), and better biodistribution than free celastrol. A cytotoxicity assay indicated that free celastrol had lower 50% inhibiting concentration values than the liposomal celastrol; however, treatment of subcutaneous xenografts with 1 mg/kg of liposomal celastrol induced greater antitumor activity than free celastrol at an equimolar concentration. In addition, a 4 mg/kg dose of liposomal celastrol had fewer severe side effects than free celastrol at the same dose. In this study, we found that the use of liposomes as a carrier of celastrol increased the bioavailability and reduced the side effects of the compound. Our findings suggest that liposomal celastrol should be further investigated in the clinical setting.
A Microparticle Enhanced Nephelometric Immunoassay (Nephelia<sup>R</sup>∗) Applied to Thymulin Measurement (1991)

This article describes a microparticle enhanced nephelometric immunoassay (Nephelia) applied to the quantification of the thymic peptide hormone thymulin. Nephelia uses antibody recognition by the antithymulin antiserum in a competitive reaction between free thymulin and thymulin bound to the microspheres. The binding between microsphere and thymulin is achieved with the aid of a protein carrier. The sensitivity of the competitive reaction varied with the protein carrier and the antiserum sample. The most efficient reaction was obtained with the thymulin-metallothionein-microsphere conjugates; as little as 5 pg/ml of thymulin could be detected. In adult human serum or in its ultra-filtrate, spiked synthetic thymulin was totally recovered. Measurement of thymulin in serum or ultra-filtrate samples demonstrated the presence of interference from molecules in the serum. Nephelia led to the same conclusions as those reported with other methods and performs as well, and is more simple to use than radio- or enzymo-immunoassays for thymulin measurement.
Open Source Software – Implications on Technology Management (2012)

Over the past few years, major IT and non-It companies have increasingly adopted open source software (OSS). OSS is developed by organized communities of interested parties and sometimes by major software companies.OSS is developed by applying high quality standards and rigorous processes used when developing proprietary softwares. In most of the publications, much of the assessment of the drivers of growth and factors which hinder the development of OSS has been done form the technical perspective .Managerial perceptions of benefits and drawbacks that impact the organizational adoption of OSS has been neglected due to its focus on software development. In this paper we have tried to analyze the benefits and drawbacks mainly from the perspective of the IS/IT managers by analyzing various case studies of the leading companies that adopted OSS in their software portfolios. We also conducted surveys with two leading corporations like Nike and Intel in the city of Portland in Orgeon and also tried to contact the people from few global companies. After analyzing surveys and case studies we found out that benefits outweigh drawbacks in adoption of OSS. Companies are strategically adopting OSS as they have incorporated OSS in their IT strategies. The issues which were thought to be hindering the growth of OSS were found to be insignificant in front of the large amount of savings, escape from vendor-lock-in and customization of processes which companies are able to achieve after switching to OSS. Despite of many benefits some concerns surfaced up like lack of formal guidelines for the adoption of OSS in an organization. Lack of management support also hinders the adoption of OSS. OSS can be the best choice for the company if it aligns its business objectives with particular OSS before switching to it. Today,OSS is in the software portfolio of more than seventy five percent of the major companies and is expected that by 2016 OSS will be in mission critical software portfolios of more than ninety nine percent of global companies.
Molecular biology of bone remodelling. (2008)

Bone remodelling is an active and dynamic process that relies on the correct balance between bone resorption by osteoclasts and bone deposition by osteoblasts. Moreover, these two functions must be tightly coupled not only quantitatively, but also in time and space. When the coupling is lost, the correct bone mass could be compromised, leading to several skeletal pathologies. Indeed, bone loss and osteoporosis are the result of an increased osteoclast function and/or a reduced osteoblast activity. In contrast, other pathologies are related to osteoclast failure to resorbe bone, such as osteopetrosis, a rare genetic disorder characterized by an increased bone mass and also linked to an impairment of bone marrow functions. Starting from these assumptions, it is necessary to more deeply understand the molecular mechanisms regulating bone cell functions. Indeed, recent studies evidenced a complex interplay between the immune and skeletal systems, which share several regulatory molecules including cytokines, receptors and transcription factors. These data allowed to more deeply understand the mechanisms underlying bone mass regulation and could open new avenue to identify target molecules for alterantive therapies more efficacious against bone diseases.
Lacunarity of fractal superlattices: a remote estimation using wavelets (2005)

The lacunarity provides a useful parameter for describing the distribution of gap sizes in discrete self-similar (fractal) superlattices and is used in addition to the similarity dimension to describe fractals. We show here that lacunarity, as well as the similarity dimension, can be remotely estimated from the wavelet analysis of superlattices impulse response. As a matter of fact, the skeleton - the set of wavelet-transform modulus-maxima - of the reflected signal overlaps two hierarchical structures in the time-scale domain: such that one allows the direct remote extraction of the similarity dimension, while the other may provide an accurate estimation of the lacunarity of the interrogated superlattice. Criteria for the choice of the mother wavelet are established for impulse response corrupted by additive Gaussian white noise.
Lipoxin A <sub>4</sub> Inhibits <i>Porphyromonas gingivalis</i> -Induced Aggregation and Reactive Oxygen Species Production by Modulating Neutrophil-Platelet Interaction and CD11b Expression (2011)

Porphyromonas gingivalis is an etiological agent that is strongly associated with periodontal disease, and it correlates with numerous inflammatory disorders, such as cardiovascular disease. Circulating bacteria may contribute to atherogenesis by promoting CD11b/CD18-mediated interactions between neutrophils and platelets, causing reactive oxygen species (ROS) production and aggregation. Lipoxin A₄ (LXA₄) is an endogenous anti-inflammatory and proresolving mediator that is protective of inflammatory disorders. The aim of this study was to investigate the effect of LXA₄ on the P. gingivalis-induced activation of neutrophils and platelets and the possible involvement of Rho GTPases and CD11b/CD18 integrins. Platelet/leukocyte aggregation and ROS production was examined by lumiaggregometry and fluorescence microscopy. Integrin activity was studied by flow cytometry, detecting the surface expression of CD11b/CD18 as well as the exposure of the high-affinity integrin epitope, whereas the activation of Rac2/Cdc42 was examined using a glutathione S-transferase pulldown assay. The study shows that P. gingivalis activates Rac2 and Cdc42 and upregulates CD11b/CD18 and its high-affinity epitope on neutrophils, and that these effects are diminished by LXA₄. Furthermore, we found that LXA₄ significantly inhibits P. gingivalis-induced aggregation and ROS generation in whole blood. However, in platelet-depleted blood and in isolated neutrophils and platelets, LXA₄ was unable to inhibit either aggregation or ROS production, respectively. In conclusion, this study suggests that LXA₄ antagonizes P. gingivalis-induced cell activation in a manner that is dependent on leukocyte-platelet interaction, likely via the inhibition of Rho GTPase signaling and the downregulation of CD11b/CD18. These findings may contribute to new strategies in the prevention and treatment of periodontitis-induced inflammatory disorders, such as atherosclerosis.
A temporally oriented data model (1986)

The research into time and data models has so far focused on the identification of extensions to the classical relational model that would provide it with “adequate” semantic capacity to deal with time. The temporally oriented data model (TODM) presented in this paper is a result of a different approach, namely, it directly operationalizes the pervasive three-dimensional metaphor for time. One of the main results is thus the development of the notion of the data cube: a three-dimensional and inherently temporal data construct where time, objects, and attributes are the primary dimensions of stored data. TODM's cube adds historical depth to the tabular notions of data and provides a framework for storing and retrieving data within their temporal context. The basic operations in the model allow the formation of new cubic views from existing ones, or viewing data as one moves up and down in time within cubes. This paper introduces TODM, a consistent set of temporally oriented data constructs, operations, and constraints, and then presents TOSQL, a corresponding end-user's SQL-like query syntax. The model is a restricted but consistent superset of the relational model, and the query syntax incorporates temporal notions in a manner that likewise avoids penalizing users who are interested solely in the current view of data (rather than in a temporal perspective). The naturalness of the spatial reference to time and the added semantic capacity of TODM come with a price—the definitions of the cubic constructs and basic operations are relatively cumbersome. As rudimentary as it is, TODM nonetheless provides a comprehensive basis for formulating an external data model for a temporally oriented database.
Accurate estimation of total leakage current in scaled CMOS logic circuits based on compact current modeling (2003)

Dramatic increase of subthreshold, gate and reverse biased junction band-to-band-tunneling (BTBT) leakage in scaled devices, results in the drastic increase of total leakage power in a logic circuit. In this paper a methodology for accurate estimation of the total leakage in a logic circuit based on the compact modeling of the different leakage current in scaled devices has been developed. Current models have been developed based on the exact device geometry, 2-D doping profile and operating temperature. A circuit level model of junction BTBT leakage (which is unprecedented) has been developed. Simple models of the subthreshold current and the gate current have been presented. Here, for the first time, the impact of quantum mechanical behavior of substrate electrons, on the circuit leakage has been analyzed. Using the compact current model, a transistor has been modeled as a Sum of Current Sources (SCS). The SCS transistor model has been used to estimate the total leakage in simple logic gates and complex logic circuits (designed with transistors of 25nm effective length) at the room and at the elevated temperatures.
이상의 수 베리에이션과 형상화이미지 (2018)

Recently, I published literary books called Literature and Mathematics I and II. Some contents of this article are partly extracted in these books....
Interfacial layer formations between Cu(In,Ga)Se2 and InxSy layers (2005)

Cu ( In , Ga ) Se 2 (CIGS) thin-film solar cells with InxSy buffer layers deposited by physical vapor deposition yield efficiencies of up to 14.8%. For substrate temperatures during the InxSy deposition ranging from 23to200°C, air annealing of the completed solar cells leads to an improvement of the photovoltaic performance. However, at substrate temperatures of 300°C, the efficiencies are practically zero, and air annealing does not improve this value. To understand the effects of substrate temperature and air annealing on the CIGS/InxSy interfaces of the solar cells, these interfaces have been studied by means of bright-field and high-resolution transmission electron microscopy, selected-area electron diffraction (SAED), and energy-dispersive x-ray spectrometry (EDX). It is shown that air annealing leads to a substantial Cu depletion on the CIGS side of the CIGS/InxSy interface, probably inducing the formation of a compositionally graded interface between the buffer and CIGS. For the 300°C sample, CuIn5S8 formed instead of InxSy, as identified by means of SAED and EDX. The large density of vacancies and defects in the spinel-type cubic crystal structure of CuIn5S8 provides a large number of recombination centers at the heterojunction of the solar cell, thus deteriorating considerably its photovoltaic performance.
Compiler-guided leakage optimization for banked scratch-pad memories (2005)

Current trends indicate that leakage energy consumption will be an important concern in upcoming process technologies. In this paper, we propose a compiler-based leakage energy optimization strategy for on-chip scratch-pad memories (SPMs). The idea is to divide SPM into banks and use compiler-guided memory-data layout optimization and data migration to maximize SPM bank idleness, thereby increasing the chances of placing banks into a low-power (low-leakage) state. Our experimental results with eight applications show that the proposed compiler-based strategy is very effective in reducing leakage energy of on-chip SPMs.