gebhart/patrepeval huggingface dataset:
Viral Vector-Mediated 12/15-Lipoxygenase Overexpression in Vascular Smooth Muscle Cells Enhances Inflammatory Gene Expression and Migration (2007)

Increased expression and activity of 12/15-lipoxygenase (12/15-LO) in vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetes and vascular complications. However, the consequences of 12/15-LO overexpression for VSMC migration and inflammatory gene expression are not known. In this study, 12/15-LO was overexpressed using adeno- and baculoviral vectors in human VSMC (HVSMCs) and proatherogenic responses compared with control enhanced green fluorescent protein (EGFP)-expressing cells. HVSMCs transduced with 12/15-LO viruses expressed high levels of enzymatically active protein and produced increased levels of the LO product, 12(S)-hydroxyeicosatetraenoic acid. 12/15-LO-overexpressing HVSMCs exhibited increased oxidant stress, activation of p38 mitogen-activated protein kinase, migration and inflammatory gene expression relative to HVSMCs expressing EGFP. Furthermore, inflammatory gene expression induced by 12/15-LO overexpression was abolished by anti-oxidants, siRNAs targeting p65 (nuclear factor-kappaB), or new-generation baculoviruses expressing inhibitory IkappaBalpha or IkappaBalpha superrepressor mutant. Thus, we have used novel viral vector delivery systems, including baculoviruses, for the first time to deliver foreign genes into VSMCs and thereby demonstrated that 12/15-LO overexpression increases oxidant stress, mitogen-activated protein kinase activation, migration and inflammatory genes in VSMCs and that NF-kappaB is a key downstream effector. Enhanced proatherogenic responses in VSMCs triggered by increased 12/15-LO levels under pathological conditions may contribute to vascular dysfunction.
Spin orbit torques induced magnetization reversal through asymmetric domain wall propagation in Ta/CoFeB/MgO structures (2018)

The magnetization reversal induced by spin orbit torques in the presence of Dzyaloshinskii-Moriya interaction (DMI) in perpendicularly magnetized Ta/CoFeB/MgO structures were investigated by using a combination of Anomalous Hall effect measurement and Kerr effect microscopy techniques. By analyzing the in-plane field dependent spin torque efficiency measurements, an effective field value for the DMI of ~300 Oe was obtained, which plays a key role to stabilize Néel walls in the film stack. Kerr imaging reveals that the current-induced reversal under small and medium in-plane field was mediated by domain nucleation at the edge of the Hall bar, followed by asymmetric domain wall (DW) propagation. However, as the in-plane field strength increases, an isotropic DW expansion was observed before reaching complete reversal. Micromagnetic simulations of the DW structure in the CoFeB layer suggest that the DW configuration under the combined effect of the DMI and the external field is responsible for the various DW propagation behaviors.
Concepts in Clinical Pharmacokinetics, 4th Edition (2006)

Programmed manual presents basic pharmacokinetic concepts and procedures. Material relates to individualization of drug dose regimens. Topics include pharmacokinetics, halfThis book for a basic principles in clinical applications of pharmacy and community. Pharmacokinetic concepts in the rowland and a 500 bed medical center dipiro reference. Genes are probably the college of, pharmacy book outlines concepts and self instructional text. Pharmacokinetic parameters ranieri bs in the dose to assist. I'm wondering whether or self study format has been tested. Murphy has been written to found it offers information. The how to of monitoring pharmacy which are clearly yet briefly outlined. I was surprised by students and updated the russell extensive explanations are lacking. The university school of health system pharmacists wrestle with unique pharmacokinetics the most clinically. Back cover copy the basic review or not be useful for so effective and creatinine. This edition are seasoned professors students and updated the board of kentucky medical center. Murphy pharmd temple university of advances in others new fifth edition this! John he also assistant, dean of medicine at the colleges. An understanding of surgery at the, research interests include preventing drug doses to use.
Viscous Fingering Fractals in Porous Media (1985)

Gas displacing a high-viscosity fluid in a two-dimensional porous disk intrudes in the form of ramified fingers similar to the structures obtained in diffusion-limited aggregation. We find that the resulting finger structures are described by a fractal dimension $D=1.62\ifmmode\pm\else\textpm\fi{}0.04$ consistent with $D$ for diffusion-limited aggregation clusters. This result confirms the analogy between diffusion-limited aggregation and two-fluid displacement in porous media introduced by Paterson.
Natural killer cells in cross-regulation of IL-12 by IL-10 in<i>Leishmania</i>antigen-stimulated blood donor cells (1999)

We have previously shown that natural killer (NK) cells play a role in protection against leishmaniasis. Furthermore, we have shown that NK cells in mononuclear cells derived from unexposed donors are induced to proliferate in vitro in response to leishmanial antigens. Since interleukin (IL)-12, a strong inducer of NK cells, acts on the early events in NK cells and T-cells, and is considered as an adjuvant for use in a potential antileishmaniasis antigen, we wished to investigate how this cytokine influences the in vitro Leishmania induced proliferative and cytokine response in healthy donors. We demonstrate that in an innate response to Leishmania antigen involving NK cells, a critical level of IL-12 is required to induce interferon (IFN)-gamma secretion below which, IL-10 is released in amounts which apparently inhibit IFN-gamma secretion and cellular proliferation. However, at higher IL-12 levels, there is simultaneous secretion of IFN-gamma and IL-10 as well as proliferation of cells. In a similar vein, exogenous IL-10 in turn inhibited IFN-gamma secretion as well as proliferation when used at low/medium concentrations, but at high concentrations this effect was abolished and replaced by the simultaneous detection of IFN-gamma, IL-10 and proliferation. The contribution of NK cells in cross regulation of these two very important immuneregulatory cytokines and the effect of exogenous IL-12 in a Leishmania driven response are discussed.
Simulation and presentation of curved surface in virtual reality environment through surface display (2002)

Force feedback can be thought as a concept which was motivated by the phenomenon of contact. Efforts were made to describe cross sections in interfaces and methodologies to realize force feedback from differences in the cross sections. Based on this discussion. The concept of surface display was submitted and technical issues for the implementation of the concept were pointed out. A prototype device to demonstrate the concept was created and solutions for technical issues mere suggested. The concept of surface display is an idea to present the surface of a virtual object itself to the user, rather than the sensation of force or tactile caused by the contact with the virtual object. The prototype device consisted of a mechanism to form arbitrary surfaces and sensors to measure the force affected on the surface. The control and calculation methods for this device are also described.
The nature of cellulose as related to its application as a zinc-silver oxide battery separator (1971)

Cellulose application as zinc silver oxide battery separator, considering chemical stability, cellophane properties, polymerization and crystallinity
Clinicopathology profile evaluated against several risk factors in breast cancer cases (1999)

The second batch case-control study on breast cancer has been conducted as a joint study between Indonesian and Japan. Two hundred and twenty six ( The age distribution in some high risk areas showed at age 35 to 55 years, with a single peak between 40 to 50. There was no difference in number of cases in respect to tumor site and menopausal status. The majority of cases 81.6 % were in advanced stage ( l!JA: 17.7%, JflB: 56.2% and JV: 11.9%) while in contrast stage l and fl were very rare ( 1.3% and 11.9% respectively ). Only 75 cases were operable; simple mastectomy was the most frequent surgery carried out (60.0%), followed by modified radical mastectomy ( 26. 7%), classical radical mastectomy ( 12%) and breast conserving treatment ( 1.3%). The specimens were reviewed using classification recommended by the Japanese Breast Cancer Society revealed invasive ductal carcinoma ( 90.4 o/o) and the special type (9.6 o/o) . Several risk factors were analyzed for their influence to the development of breast cancer; namely: marital status, age at first marriage, menarche, menopausal status, lactation, family history of breast cancer; use of contraceptive and fat consumption. Among the characteristics studied, the following factors significantly increased the risk of breast cancer: menopausal status (RR= 1.51; 95% Cl: 1.10-2.09), non-lactating children (RR=l.83; 95% CJ: 1.07-3. Jl ) and fat consumption (RR=2.61; 95% Cl: 1.86-3.68), while the use of contraceptive showed protective effect. Thefindings will be discussed in its benefit relative to both the improvement of the treatment modality and the cancer control prog ram.
Unobscured mirror designs (2002)

This paper reviews unobscured multiple-mirror imaging designs ranging from two to many mirrors, the ranges of operating conditions of each configuration, their strengths and limitations, and areas of application.
Amino Acid Sequence of Troponin-I from Akazara Scallop Striated Adductor Muscle (1998)

The complete amino acid sequence of Akazara scallop, Chlamys nipponensis akazara, troponin-I was determined by automated Edman degradation. It is composed of 292 amino acid residues with a blocked N-terminus. The Mr is calculated to be 34,678, about 14,000 larger than that of vertebrate skeletal troponin-I but significantly smaller than the 52,000 that had been estimated by SDS-polyacrylamide gel electrophoresis. The homologous sequence to vertebrate and arthropoda troponin-Is is found in the C-terminal region. In particular, the sequence of the regions essential for binding to actin and troponin-C is highly conserved. On the other hand, Akazara scallop troponin-I has 100-133 extra residues at the N-terminus compared with vertebrate troponin-I. This extra region is rich in Glu and Arg and has a unique sequence, that shows in part a high sequence homology with the tropomyosin-binding site of troponin-T and caldesmon.
Magnetospheric physics: Magnetic fields (1975)

Progress in magnetospheric physics during the last quadrennium was not achieved through any one or a number of significant new discoveries or breakthroughs. Rather the advance was manifested more in gradual changes in the collective magnetospheric consciousness: the spreading acceptance that the magnetosphere is indeed ‘open,’ the increasing awareness of the key role of magnetospheric dynamics (substorms) in governing the various magnetospheric processes, a deeper appreciation of the role of electric fields and currents parallel to the magnetic field, the unfolding of the complexities of the earth's bow shock and associated phenomena, a strengthening attack on the merging process via theoretical and laboratory work, and the generation by several groups of magnetospheric magnetic field models based on observational data. The quadrennium also appears to have marked the end of the exploratory phase of magnetospheric studies with the launching of spacecraft into the last unexplored reaches of the magnetosphere and the resultant discovery and investigation of the polar cusp, at the boundary between the closed and open field lines over the day side magnetosphere, and the plasma mantle, a boundary layer of flowing plasma in the high‐latitude magnetotail. New records for closest boundary positions were established during this period. Previously, the magnetopause had been observed at synchronous orbit on ATS 1. However, in March 1970, even the shock crossed synchronous orbit, and solar wind plasma was detected at synchronous orbit. Then in August 1972, Explorer 45 crossed the magnetopause at 5.2 R E . If it is assumed that the magnetopause and shock surface simply changed scale sizes, the ATS 5 observation of solar wind represents the greater magnetospheric distortion.
Expression of interleukin-8 receptors in endometriosis (2004)

These findings suggest that IL-8 and its receptors may be involved in the pathogenesis of endometriosis.
Implementing and evaluating multithreaded triad census algorithms on the Cray XMT (2009)

Commonly represented as directed graphs, social networks depict relationships and behaviors among social entities such as people, groups, and organizations. Social network analysis denotes a class of mathematical and statistical methods designed to study and measure social networks. Beyond sociology, social network analysis methods are being applied to other types of data in other domains such as bioinformatics, computer networks, national security, and economics. For particular problems, the size of a social network can grow to millions of nodes and tens of millions of edges or more. In such cases, researchers could benefit from the application of social network analysis algorithms on high-performance architectures and systems. The Cray XMT is a third generation multithreaded system based on the Cray XT-3/4 platform. Like most other multithreaded architectures, the Cray XMT is designed to tolerate memory access latencies by switching context between threads. The processors maintain multiple threads of execution and utilize hardware-based context switching to overlap the memory latency incurred by any thread with the computations from other threads. Due to its memory latency tolerance, the Cray XMT has the potential of significantly improving the execution speed of irregular data-intensive applications such as those found in social network analysis. In this paper, we describe our experiences in developing and optimizing two implementations of a social network analysis method known as triadic analysis to execute on the Cray XMT. The two implementations possess different execution complexities, qualities, and characteristics. We evaluate how the various attributes of the codes affect their performance on the Cray XMT. We also explore the effects of different compiler options and execution strategies on the different triadic analysis implementations and identify general XMT programming issues and lessons learned.
Design of a large-scale storage-class RRAM system (2013)

Resistive Random Access Memory (RRAM) is a promising next generation non-volatile memory (NVM) technology, thanks to its performance potential, endurance and ease-of-integration with standard silicon CMOS processes. While prior work has evaluated RRAM as a replacement for DRAM or even cache memory, to our knowledge there is no prior study that has investigated whether RRAM could be a viable NAND flash replacement in building large-scale storage-class memory systems. Motivated by this observation, our paper first discusses and quantifies the main problems associated with RRAM that prevent it from replacing NAND flash. The main solution we propose, "slab-based memory access with local/global bitlines," enables dense RRAM islands but can also cause performance related problems. To compensate for the latter, we also propose exploiting internal resource parallelism in RRAM and employing optimized data movement interfaces. Our extensive experimental evaluation using a cycle-level NVM simulator and real workloads under diverse computing domains indicate that the proposed architecture can provide 2.95 ~ 8.28 times better bandwidth and 66% ~ 88% shorter latency as compared to the conventional NAND flash, and improve the system-level performance of our workloads by 5x, with a storage capacity similar to that of the state-of-the-art NAND flash.
Microporous Metal−Organic Frameworks Incorporating 1,4-Benzeneditetrazolate:  Syntheses, Structures, and Hydrogen Storage Properties (2006)

The potential of tetrazolate-based ligands for forming metal-organic frameworks of utility in hydrogen storage is demonstrated with the use of 1,4-benzeneditetrazolate (BDT(2)(-)) to generate a series of robust, microporous materials. Reaction of H(2)BDT with MnCl(2).4H(2)O and Mn(NO(3))(2).4H(2)O in N,N-diethylformamide (DEF) produces the two-dimensional framework solids Mn(3)(BDT)(2)Cl(2)(DEF)(6) (1) and Mn(4)(BDT)(3)(NO(3))(2)(DEF)(6) (2), whereas reactions with hydrated salts of Mn(2+), Cu(2+), and Zn(2+) in a mixture of methanol and DMF afford the porous, three-dimensional framework solids Zn(3)(BDT)(3)(DMF)(4)(H(2)O)(2).3.5CH(3)OH (3), Mn(3)(BDT)(3)(DMF)(4)(H(2)O)(2).3CH(3)OH.2H(2)O.DMF (4), Mn(2)(BDT)Cl(2)(DMF)(2).1.5CH(3)OH.H(2)O (5), and Cu(BDT)(DMF).CH(3)OH.0.25DMF (6). It is shown that the method for desolvating such compounds can dramatically influence the ensuing gas sorption properties. When subjected to a mild evacuation procedure, compounds 3-6 exhibit permanent porosity, with BET surface areas in the range 200-640 m(2)/g. The desolvated forms of 3-5 store between 0.82 and 1.46 wt % H(2) at 77 K and 1 atm, with enthalpies of adsorption in the range 6.0-8.8 kJ/mol, among the highest so far reported for metal-organic frameworks. In addition, the desolvated form of 6 exhibits preferential adsorption of O(2) over H(2) and N(2), showing promise for gas separation and purification applications.
Inflammation and Rate of Cognitive Change in High-Functioning Older Adults (2008)

Although high levels of inflammation are associated with incident cognitive impairment, these results do not generalize to the full range of cognitive changes, where the role of inflammation appears to be marginal.
Synthetic Mimics of Bacterial Lipid A Trigger Optical Transitions in Liquid Crystal Microdroplets at Ultralow Picogram-per-Milliliter Concentrations (2015)

We report synthetic six-tailed mimics of the bacterial glycolipid Lipid A that trigger changes in the internal ordering of water-dispersed liquid crystal (LC) microdroplets at ultralow (picogram-per-milliliter) concentrations. These molecules represent the first class of synthetic amphiphiles to mimic the ability of Lipid A and bacterial endotoxins to trigger optical responses in LC droplets at these ultralow concentrations. This behavior stands in contrast to all previously reported synthetic surfactants and lipids, which require near-complete monolayer coverage at the LC droplet surface to trigger ordering transitions. Surface-pressure measurements and SAXS experiments reveal these six-tailed synthetic amphiphiles to mimic key aspects of the self-assembly of Lipid A at aqueous interfaces and in solution. These and other results suggest that these amphiphiles trigger orientational transitions at ultralow concentrations through a unique mechanism that is similar to that of Lipid A and involves formation of inverted self-associated nanostructures at topological defects in the LC droplets.
Dietary Lipids Influence Insulin Action <sup>a</sup> (1993)

Insulin binding and insulin responsiveness are altered by dietary fat-induced changes in the fatty acid composition of the adipocyte plasma membrane. Feeding a high P/S diet increased polyunsaturated fatty acid content of major membrane phospholipids of adipocyte plasma membrane in normal and diabetic animals, increased membrane linoleic acid content, and prevented a decrease in arachidonic acid level in diabetic animals. The high P/S diet increased insulin binding in control animals. Animals fed the high P/S diet had significantly higher rates of insulin-stimulated glucose transport and lipogenesis than did animals fed the low P/S diet. Feeding a high P/S diet significantly increased the amount of glucose transported when expressed as a function of the specific amount of insulin bound. To determine if dietary fat-induced alterations in the fatty acid composition of skeletal muscle lipid alter insulin-dependent and basal muscle metabolism, contralateral epitrochlearis and extensor digitorum longus muscles were isolated and incubated in vitro. High levels of dietary omega-3 fatty acids reduced PGE2 and PGF2 alpha synthesis in extensor digitorum longus and epitrochlearis muscle. Insulin increased glucose and amino acid transport; the increase in glucose transport by insulin was significantly greater after consumption of the high omega-3 fatty acid diet. Rats fed high levels of omega-3 fatty acids showed reduced net protein degradation in the presence and absence of insulin due to decreased rates of protein degradation and synthesis. These experiments indicate that high levels of dietary omega-3 fatty acids alter muscle membrane composition, glucose transport, and metabolism of muscle protein. To determine if dietary fatty acids alter the onset of diabetes and insulin binding to liver nuclei in spontaneously diabetic rats, weanling rats were fed chow or semipurified diets containing 20% (w/w) fat of either high or low P/S ratio. Feeding a high P/S diet increased insulin binding to liver nuclei of control and diabetic animals. Although diet did not alter the onset of diabetes, insulin binding to liver nuclei is higher in animals at the onset of diabetes than in highly diabetic animals. Eight-week-old female C57 B 6J lean and ob/ob mice were fed semipurified diets containing 20% (w/w) fat of either high or low P/S ratio to investigate the effect of diet on specific binding of insulin to liver nuclei. Insulin binding was highest in nuclei from lean mice fed a high P/S diet. Specific binding of insulin to nuclei from obese mice was also increased by the high P/S diet, but to a lesser extent.(ABSTRACT TRUNCATED AT 250 WORDS)