gebhart/patrepeval huggingface dataset:
Representations of Keypoint-Based Semantic Concept Detection: A Comprehensive Study (2009)

Based on the local keypoints extracted as salient image patches, an image can be described as a ¿bag-of-visual-words (BoW)¿ and this representation has appeared promising for object and scene classification. The performance of BoW features in semantic concept detection for large-scale multimedia databases is subject to various representation choices. In this paper, we conduct a comprehensive study on the representation choices of BoW, including vocabulary size, weighting scheme, stop word removal, feature selection, spatial information, and visual bi-gram. We offer practical insights in how to optimize the performance of BoW by choosing appropriate representation choices. For the weighting scheme, we elaborate a soft-weighting method to assess the significance of a visual word to an image. We experimentally show that the soft-weighting outperforms other popular weighting schemes such as TF-IDF with a large margin. Our extensive experiments on TRECVID data sets also indicate that BoW feature alone, with appropriate representation choices, already produces highly competitive concept detection performance. Based on our empirical findings, we further apply our method to detect a large set of 374 semantic concepts. The detectors, as well as the features and detection scores on several recent benchmark data sets, are released to the multimedia community.
The Hypothalamic-Pituitary-Adrenal Axis in Pregnancy: Challenges in Disease Detection and Treatment (2005)

Pregnancy dramatically affects the hypothalamic-pituitary-adrenal axis leading to increased circulating cortisol and ACTH levels during gestation, reaching values in the range seen in Cushing's syndrome (CS). The cause(s) of increased ACTH may include placental synthesis and release of biologically active CRH and ACTH, pituitary desensitization to cortisol feedback, or enhanced pituitary responses to corticotropin-releasing factors. In this context, challenges in diagnosis and management of disorders of the hypothalamic-pituitary-adrenal axis in pregnancy are discussed. CS in pregnancy is uncommon and is associated with fetal morbidity and mortality. The diagnosis may be missed because of overlapping clinical and biochemical features in pregnancy. The proportion of patients with primary adrenal causes of CS is increased in pregnancy. CRH stimulation testing and inferior petrosal sinus sampling can identify patients with Cushing's disease. Surgery is a safe option for treatment in the second trimester; otherwise medical therapy may be used. Women with known adrenal insufficiency that is appropriately treated can expect to have uneventful pregnancies. Whereas a fetal/placental source of cortisol may mitigate crisis during gestation, unrecognized adrenal insufficiency may lead to maternal or fetal demise either during gestation or in the puerperium. Appropriate treatment and management of labor are reviewed.
The Dual-Specificity CLK Kinase Induces Neuronal Differentiation of PC12 Cells (1994)

CLK is a dual-specificity protein kinase capable of phosphorylating serine, threonine, and tyrosine residues. We have investigated the action of CLK by establishing stable PC12 cell lines capable of inducibly expressing CLK. Expression of CLK in stably transfected PC12 cells mimicked a number of nerve growth factor (NGF)-dependent events, including the morphological differentiation of these cells and the elaboration of neurites. Moreover, CLK expression enhanced the rate of NGF-mediated neurite outgrowth of these cells, indicating that CLK expression and NGF treatment activate similar signal transduction pathways. CLK expression, unlike NGF, was not able to promote PC12 cell survival in serum-free media, demonstrating that CLK only partially recapitulated the actions of NGF on these cells and that the biochemical pathways necessary for morphological differentiation can be stimulated without also stimulating those necessary for survival. Induction of CLK expression also resulted in the selective activation of protein kinases that are components of growth factor-stimulated signal transduction cascades, including ERK1, ERK2, pp90RSK, and S6PKII. Induction of CLK expression, however, did not stimulate pp70S6K or Fos kinase, two NGF-sensitive protein kinases. These data indicate that CLK action mediates the morphological differentiation of these cells through its capacity to independently stimulate signal transduction pathways normally employed by NGF.
Measuring competition in health care markets. (2001)

Attention to several key issues will strengthen measurement. Important components of successful measurement are: careful identification of the products and market areas for study; selection of Herfindahl-Hirschman or other indices to fit the issues being considered; consideration of econometric problems, like endogeneity, with common measures; and attention to the ways that current marketplace changes, like growth in managed care, affect the performance of classic measures. Data needed for constructing measures are also frequently scarce, insufficient, or both. Measurement could be improved with access to better data.
Les femmes dans la bande dessinée d'auteur depuis les années 1970. Itinéraires croisés : Claire Bretécher, Chantal Montellier, Marjane Satrapi (2009)

Histoire de la bande dessinée féminine de Claire Brétecher à <i>Persepolis</i> de Marjane Satrapi
Hyaluronidase and Hyaluronan Oligosaccharides Promote Neurological Recovery after Intraventricular Hemorrhage (2016)

Intraventricular hemorrhage (IVH) in premature infants results in inflammation, arrested oligodendrocyte progenitor cell (OPC) maturation, and reduced myelination of the white matter. Hyaluronan (HA) inhibits OPC maturation and complexes with the heavy chain (HC) of glycoprotein inter-α-inhibitor to form pathological HA (HC-HA complex), which exacerbates inflammation. Therefore, we hypothesized that IVH would result in accumulation of HA, and that either degradation of HA by hyaluronidase treatment or elimination of HCs from pathological HA by HA oligosaccharide administration would restore OPC maturation, myelination, and neurological function in survivors with IVH. To test these hypotheses, we used the preterm rabbit model of glycerol-induced IVH and analyzed autopsy samples from premature infants. We found that total HA levels were comparable in both preterm rabbit pups and human infants with and without IVH, but HA receptors--CD44, TLR2, TLR4--were elevated in the forebrain of both humans and rabbits with IVH. Hyaluronidase treatment of rabbits with IVH reduced CD44 and TLR4 expression, proinflammatory cytokine levels, and microglia infiltration. It also promoted OPC maturation, myelination, and neurological recovery. HC-HA and tumor necrosis factor-stimulated gene-6 were elevated in newborns with IVH; and depletion of HC-HA levels by HA oligosaccharide treatment reduced inflammation and enhanced myelination and neurological recovery in rabbits with IVH. Hence, hyaluronidase or HA oligosaccharide treatment represses inflammation, promotes OPC maturation, and restores myelination and neurological function in rabbits with IVH. These therapeutic strategies might improve the neurological outcome of premature infants with IVH. Significance statement: Approximately 12,000 premature infants develop IVH every year in the United States, and a large number of survivors with IVH develop cerebral palsy and cognitive deficits. The onset of IVH induces inflammation of the periventricular white matter, which results in arrested maturation of OPCs and myelination failure. HA is a major component of the extracellular matrix of the brain, which regulates inflammation through CD44 and TLR2/4 receptors. Here, we show two mechanism-based strategies that effectively enhanced myelination and neurological recovery in preterm rabbit model of IVH. First, degrading HA by hyaluronidase treatment reduced CD44 and TLR4 expression, proinflammatory cytokines, and microglial infiltration, as well as promoted oligodendrocyte maturation and myelination. Second, intraventricular injection of HA oligosaccharide reduced inflammation and enhanced myelination, conceivably by depleting HC-HA levels.
Th1/Th2 Cytokine Production in Patients with Chronic Hepatitis C Virus Infection (2002)

Background : To evaluate the immunoregulatory mechanism of Th1/Th2 cells in patients with the Hepatitis C virus infection, which is characterized by persistence and chronic progression, Th1 cytokine (IFN-, IL-12, IL-2) and Th2 cytokine (IL-4) responses were investigated. Methods : Th1 cytokine (IFN-, IL-12, and IL-2) and Th2 cytokine (IL-4) for serum levels, spontaneous production of peripheral mononuclear cells (PBMC) and PHA-stimulated production of PBMC were estimated by the ELISA method in 19 patients with chronic Hepatitis C (CH), 12 with cirrhosis of the liver (LC) and 12 healthy subjects. Results : The IFN- serum levels increased significantly in the CH and LC compared with the healthy controls (P production of PBMC increased significantly in patients with CH and LC compared with the healthy controls (P showed positive correlations with the lymphocyte counts and IL-12 levels in CLD. Conclusions : Although the Th1 immune response for serum and spontaneous production in CH and LC was normal or increased, the Th1 immune response for PHA stimulation decreased or showed a low-tendency. It is suggested that the cytokine imbalance in the CLD may contribute to the persistence of HCV infection; however, it was not correlated with chronic progression.
Chromosomal Localization of Five Murine HSP70 Gene Family Members: Hsp70.1, Hsp70-2, Hsp70-3, Hsc70t, and Grp78 (1993)

The 70,000-D heat shock protein (HSP70) gene family includes both heat-inducible and constitutively expressed genes. We have mapped five murine HSP70 genes to specific sites on three separate chromosomes. Southern blot analysis of Chinese hamster x mouse somatic cell DNAs was used to assign the gene for the 78,000-D glucose-regulated protein (Grp78) to Chromosome (Chr) 2, the male germ cell-specific Hsp70-2 and Hsc70t genes to Chr 12 and Chr 17, respectively, and the heat-inducible Hsp70-3 gene also to Chr 17. Southern blot analysis of DNA from the progeny of two multilocus crosses confirmed the Grp78 location on Chr 2 and suggested the order: centromere-Vim-Abl-Grp78-Hc. Similar analysis also confirmed the initial Hsp70-2 assignment to Chr 12 with the order: Hsp70-2-Aat-Igh. The Hsp70-3 and Hsc70t genes on Chr 17, along with the heat-inducible Hsp70-1 gene, were further localized by Southern blot analysis of genomic clones to the H-2 histocompatibility region with the order: Hsp70-1-Hsp70-3-Hsc70t-Bat-6 (human G7a, valyl-tRNA synthetase).
Transverse-junction-stripe lasers with a GaAs p-n homojunction (1975)

A new semiconductor laser structure named the transverse-junction-stripe (TJS) laser, in which the active region is a GaAs p-n homojunction sandwiched between GaAlAs layers, has been developed. It is possible to operate the laser continuously at room temperature below 100 mA. The minimum threshold current is 34 and 50 mA in pulsed and continuous operation, respectively. Relatively high efficiencies have been obtained, comparable to those of conventional double-heterostructure (DH) lasers. The transverse mode is fundamental in both directions and is almost independent of input current up to three times the threshold current. The longitudinal mode stays nearly single over a wide range of input current. The TE/TM power ratio exceeds 100 at 1.5 times the threshold current.
Similarity-Driven Semantic Role Induction via Graph Partitioning (2014)

As in many natural language processing tasks, data-driven models based on supervised learning have become the method of choice for semantic role labeling. These models are guaranteed to perform well when given sufficient amount of labeled training data. Producing this data is costly and time-consuming, however, thus raising the question of whether unsupervised methods offer a viable alternative. The working hypothesis of this article is that semantic roles can be induced without human supervision from a corpus of syntactically parsed sentences based on three linguistic principles: (1) arguments in the same syntactic position (within a specific linking) bear the same semantic role, (2) arguments within a clause bear a unique role, and (3) clusters representing the same semantic role should be more or less lexically and distributionally equivalent. We present a method that implements these principles and formalizes the task as a graph partitioning problem, whereby argument instances of a verb are represented as vertices in a graph whose edges express similarities between these instances. The graph consists of multiple edge layers, each one capturing a different aspect of argument-instance similarity, and we develop extensions of standard clustering algorithms for partitioning such multi-layer graphs. Experiments for English and German demonstrate that our approach is able to induce semantic role clusters that are consistently better than a strong baseline and are competitive with the state of the art.
Commerce and the crusades (1998)

This chapter gives a striking account of how international trade in major parts of Europe was showing the first consistent signs of a revival. With the system of commerce growing up in Europe, the most important centres of trade lay in Italy. It was also observed that Venice gradually became the major channel for the supply of eastern goods to other parts of western Europe. The large-scale European military expeditions to the east, which began at the end of the 11th century, came about as a consequence of the revitalization of the western Church, and in particular of the institutions of the papacy. Furthermore, this text also explains the origins of the Crusades, which were an outlet for an intense religious piety which rose up in the late 11th century among the lay public.
Environmental applications of analytical biosensors (1996)

A review of the fundamental aspects and environmental applications of biosensors is presented. The bases of different transducer principles such as electrochemical, optical and piezoelectric are discussed. Various examples are given of the applications of such principles to develop immunosensor devices to determine common environmental contaminants. Attention is also paid to catalytic biosensors, using enzymes as sensing elements. Biosensor devices based on the use of cholinesterase and various oxidase enzymes such as tyrosinase, laccase, peroxidase and aldehyde dehydrogenase are reported. Some examples are given of the applications of other biomolecules such as whole cells, DNA or proteins, to determine pollution. Validation studies are presented comparing biosensors with chromatographic techniques to determine organophosphorus pesticides and phenolic compounds in environmental samples.
Bactericidal Activity of Glycinecin A, a Bacteriocin Derived from <i>Xanthomonas campestris</i> pv. glycines, on Phytopathogenic <i>Xanthomonas campestris</i> pv. vesicatoria Cells (2004)

The ability of glycinecin A, a bacteriocin derived from Xanthomonas campestris pv. glycines 8ra, to kill closely related bacteria has been demonstrated previously by our group. In the present study, we aimed at determining the glycinecin A-induced cause of death. Treatment with glycinecin A caused slow dissipation of membrane potential and rapid depletion of the pH gradient. Glycinecin A treatment also induced leakage of potassium ions from X. campestris pv. vesicatoria YK93-4 cells and killed sensitive bacterial cells in a dose-dependent manner. Sensitive cells were killed within 2 h of incubation, most likely due to the potassium ion efflux caused by glycinecin A. These results suggest that the bactericidal mechanism of action of glycinecin A is correlated with the permeability of membranes to hydroxyl and potassium ions, leading to the lethal activity of the bacteriocin on the target bacteria.
A study of the inhibition of pitting of aluminum by chromate (1991)

The location of chromate activity during the pitting corrosion of aluminum has been studied. Scanning vibrating probe technique monitored the current densities above cathodic and anodic sites and SIMS was used to determine the location of chromium reduction products. Products deposited preferentially on cathodes but chromates dramatically inhibited the anodic pitting processes. 8 refs., 3 figs.
Contrast-enhanced ultrasound in the detection and characterization of liver tumors. (2009)

Contrast-enhanced ultrasound (CEUS) has unique advantages over contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) in the characterization of hepatic tumors. These include the capability of real-time dynamic imaging depicting the enhancement pattern of tumors regardless of its rapidity, purely intravascular properties of the microbubble contrast agents more consistently demonstrating washout of malignancy, and capability of repetitive observation of tumor vascularity with multiple injections of microbubbles with an excellent safety profile and no nephrotoxicity. For an indeterminate mass detected on an ultrasound scan, an immediate benign diagnosis reduces the necessity of costly further imaging as well as patients' anxiety and an immediate malignant diagnosis prompts the proper work-up and management. CEUS is often served as a problem-solving tool for indeterminate lesions on prior CT or MRI scans, obviating further invasive steps. CEUS offers excellent visualization of peripheral nodular enhancement in even flash-filling or very slow-filling hemangiomas. Careful observation of early arterial filling pattern is helpful in the differentiation of focal nodular hyperplasia versus adenoma. Hepatocellular carcinoma is typically characterized by arterial hypervascularity and often late, partial washout. Metastasis shows brief arterial hypervascularity and complete rapid washout, which can improve its detection during a portal phase survey. The washout phenomenon of malignant tumors in general is useful to differentiate them from benign lesions.
Heat Transfer Aspects of Using Phase Change Material in Thermal Energy Storage Applications (2011)

Innovative methods for providing sustainable heating and cooling through thermal energy storage (TES) have gained increasing attention as heating and cooling demands in the built environment continue to climb. As energy prices continue to soar and systems reach their maximal capacity, there is an urgent need for alternatives to alleviate peak energy use. TES systems allow decoupling of energy production from energy utilization, both in location and in time. It is shown in this thesis that successful implementation of TES in the built environment alleviates peak energy load and reduces network expansion as well as the marginal energy production cost. This thesis analyzes phase change material (PCM) based TES systems in terms of material property characterization, numerical modeling and validation of thermal storage, as well as case specific techno-economic feasibility studies of system integration. The difficulties identified in latent heat TES design, such as heat transfer aspects, subcooling and identification of phase separation, have been analyzed through Temperature-History mapping and TES numerical modeling with experimental validation. This work focuses on the interdependency between resource availability, thermal charge/discharge power and storage capacity. In a situation where resource availability is limited, e.g. when using free cooling, waste heat or off-peak storage, the thermal power and storage capacity are strongly interrelated and should always be considered in unison to reach an acceptable techno-economic solution. Furthermore, when considering TES integration into an existing thermal energy distribution network, three adverse aspects are revealed in the Swedish case study: the single tariff system, the low-return temperature penalty, and the low storage utilization rate. These issues can be overcome through better adapted policies and optimized storage control strategies. Finally, despite the currently unfavorable conditions in the Swedish energy system, it is shown that TES has the potential to mitigate climate change through greenhouse gas emission reduction by displacing fossil-fuel based marginal thermal energy production.
Holographic Metalens for Switchable Focusing of Surface Plasmons (2015)

Surface plasmons polaritons (SPPs) are light-like waves confined to the interface between a metal and a dielectric. Excitation and control of these modes requires components such as couplers and lenses. We present the design of a new lens based on holographic principles. The key feature is the ability to switchably control SPP focusing by changing either the incident wavelength or polarization. Using phase-sensitive near-field imaging of the surface plasmon wavefronts, we have observed their switchable focusing and steering as the wavelength or polarization is changed.
Equal Aspiration Rates From Postpylorus and Intragastric‐Placed Small‐Bore Nasoenteric Feeding Tubes: A Randomized, Prospective Study (1992)

Postpylorus delivery of enteral feeding is perceived by many experts to be safer than intragastric delivery. To test this assumption, patients with similar Glasgow Coma Scores were given identical enteral formulas continuously via a 10-French nasoenteric tube, placed into the stomach or beyond the second portion of the duodenum. Observations were made for attainment of desired nutrition, bowel changes, and clinical signs of aspiration. Radiographs of the chest and abdomen were obtained every 3 days. If a tube migrated out of a chosen location, it was replaced. Thirty-three patients were studied. Seventeen patients were fed into the stomach and 16 patients were fed postpylorus. The mean duration of enteral feeding was 11.8 days for the gastric group and 10.9 days for the postpylorus group (p = NS). The time to deliver the desired kilocalories was 3.33 and 2.77 days (p = NS) for gastric and postpylorus-fed patients. Tubes displaced similarly in each group, gastric 0.647, postpylorus 0.750 per duration of feeding (p = NS). Chest radiographs met the criteria for aspiration pneumonia in 31.3% of gastric and 40% of postpylorus-fed patients (p = NS). Together, these data indicate that complications from enterally fed patients are equally common whether the distal port of the feeding tube is in the stomach or beyond the second portion of the duodenum.
Herpesvirus-Induced Antigens in Squamous-Cell Carcinoma in Situ of the Vulva (1981)

Antigens induced by herpes simplex virus Type 2 (HSV2) were found to be associated with squamous-cell carcinoma in situ of the vulva in nine of 10 patients. The HSV2-induced antigens are DNA-binding proteins that are normally present in the nuclei of infected cells, but in the cells of the carcinomas in situ they were found in the cytoplasm. Whole-virion structural antigens were not present, although there was serologic evidence of previous HSV2 infection in patients tested for the presence of antibodies. The observations reported here and the recent parallel rise in the prevalence of both HSV2 infections and vulvar carcinoma in situ, particularly in women under 40 years of age, suggest an association of HSV2 infection with this type of neoplasia, the nature of which remains to be determined.