gebhart/patrepeval huggingface dataset:
On guaranteed smooth scheduling for input-queued switches (2005)

Input-queued switches are used extensively in the design of high-speed routers. As switch speeds and sizes increase, the design of the switch scheduler becomes a primary challenge, because the time interval for the matching computations needed for determining switch configurations becomes very small. Possible alternatives in scheduler design include increasing the scheduling interval by using envelopes , and using a frame-based scheduler that guarantees fixed rates between input-output pairs. However, both these alternatives have significant jitter drawbacks: the jitter increases with the envelope size in the first alternative, and previously-known methods do not guarantee tight jitter bounds in the second. In this paper, we propose a hybrid approach to switch scheduling. Traffic with tight jitter constraints is first scheduled using a frame-based scheduler that achieves low jitter bounds. Jitter-insensitive traffic is later scheduled using an envelope-based scheduler. The main contribution of this paper is a scheduler design for generating low-jitter schedules. The scheduler uses a rate matrix decomposition designed for low jitter and different from the minimum-bandwidth Birkhoff-Von Neumann (BV) decomposition. In addition to generating low-jitter schedules, this decomposition in the worst case yields fewer switch configuration matrices (O(n)) than the BV decomposition (O(n/sup 2/)), and so requires far less high-speed switch memory. We develop an efficient algorithm for decomposing the rate matrix and for scheduling the permutation matrices. We prove that our low-jitter algorithm has an O(logn) factor bound on its bandwidth consumption in comparison to the minimum-bandwidth BV decomposition. Experimentally, we find that the bandwidth increase in practice is much lower than the theoretical bound. We also prove several related performance bounds for our scheduler. Finally, we propose a practical algorithm for bandwidth-guaranteed algorithm, and show how our findings could even be extended to systems with large tuning time.
Binge eating: nature, assessment, and treatment (1994)

This informative and unusually practical text brings together original and significant contributions from leading experts from a wide variety of fields. Of major importance to clinicians are the two practical manuals that comprise the final section of this volume. The Eating Disorder Examination (EDE), the major clinical interview for assessing eating disorders, is published here for the first time. It shows precisely how to elicit the key features of these disorders. The final chapter is a cognitive behavioral therapy manual written by three leading experts of this highly effective approach who draw on their own clinical experience in treating patients. This detailed manual covers all those who binge eat, including those who are overweight.
Effects of leukocyte-derived cathepsin G on platelet membrane glycoprotein Ib-IX and IIb-IIIa complexes: a comparison with thrombin (1993)

Cathepsin G is a serine, chymotrypsin-like protease released by activated polymorphonuclear leukocytes (PMN) that may act as a platelet agonist. The effect of this enzyme on platelet surface glycoproteins (Gp) Ib and IIb-IIIa was evaluated by means of a cytofluorimetric assay, using fluorescein isothiocyanate-labeled monoclonal antibodies (MoAbs) directed at the alpha chain of Gp Ib (SZ2), at Gp IX or at the complex Gp IIb-IIIa (P2), and the fibrinogen-receptor-specific MoAb PAC- 1. In human washed platelets, cathepsin G increased the binding of P2 and PAC-1, decreased the binding of SZ2, but only slightly affected the binding of anti-Gp IX. SZ2 binding decrease was more rapid in cathepsin G- than in thrombin-stimulated platelets, whereas the increase of P2 and PAC-1 binding occurred to a comparable extent with either agonist. In paraformaldehyde (PFA)-fixed and energy-depleted platelets, no effect on either Gp Ib or Gp IIb-IIIa complex was observed with thrombin. At variance, cathepsin G was still able to reduce binding of SZ2, whereas increased binding of P2 or PAC-1 antibodies was not observed. Triton X-100 permeabilization of cathepsin G-treated, PFA- fixed platelets did not restore SZ2 binding at variance with thrombin. Moreover, platelet incubation with cathepsin G resulted in the loss of ristocetin-induced agglutination in the presence of the von Willebrand factor and in the appearance of Gp Ib-derived proteolytic products in supernatants. After dissociation by EDTA pretreatment of surface Gp IIb- IIIa complexes, cathepsin G still induced increased binding of P2. Aspirin and an adenosine diphosphate scavenger system had only a slight but not significant effect on changes in antibody binding induced by cathepsin G. All these data would indicate that cathepsin G, like thrombin, interacts with platelet-surface Gp, inducing the exposure of the intracellular pool of the Gp IIb-IIIa complex with concomitant expression of a functional fibrinogen receptor. Moreover, it induces a loss of antigenic sites on Gp Ib, but the mechanism involved, a proteolytic cleavage of Gp Ib, is substantially different from that of thrombin. These changes, induced by a product of activated PMN, might reduce the reactivity of platelets to the subendothelium, while increasing their ability to undergo aggregation and release reaction.
The Solid - State Ionization Chamber (1960)

Shallow diffused silicon p-n junction detectors have been used as room-temperature particle spectrometers for protons, alpha particles, heavy ions, and fission fragments. By the use of high base resistivity devices operated at high reverse biases (> 200 volts), the width of the sensitive volume has been extended beyond 0.5 mm, permitting linear response to protons up to 9 mev. Improved diffusion techniques have resulted in more shallow diffusion depths so that the "window effect" is reduced, extending the low energy response to below 200 kev for alpha particles. Use of low-noise amplifiers has permitted observation of half-widths of the pulse height-distribution equivalent to 18 kev.
High dose naloxone in depression. (1984)

The behavioral effects of a 2 mg/kg iv bolus infusion of naloxone were compared with a placebo infusion using a double-blind design in a small group of inpatient depressives (n = 6) and normals (n = 8). Naloxone produced consistent and significant worsening in the rated signs and subjective symptoms of depression in the patients. In the normals, lesser changes in Hamilton depression and BPRS total scores were observed while none of the subjective scales were significantly altered. The data suggest that depressives manifest a more marked and subjectively more intense response to naloxone compared to normals. Further studies are required to confirm this preliminary finding and to clarify its relationship to the pathogenesis of depression.
Impact of fluorine incorporation in the polysilicon emitter of NPN bipolar transistors (1995)

We demonstrate that fluorine incorporation in the polysilicon emitter of NPN bipolar transistors significantly reduces the current gain h/sub fe/. The gain degradation can be related to a reduction of the barrier to hole transport at the poly-Si/mono-Si interface. In addition to a gain reduction, fluorinated-emitter transistors display lower base recombination currents (at low base-emitter biases) than nonfluorinated emitter devices, suggesting that fluorine passivates recombination centers in the emitter-base space charge region.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Novel self-aligned sub-micron emitter InP/InGaAs HBT's using T-shaped emitter electrode (2002)

A new self-aligned process for InP/InGaAs heterojunction bipolar transistors (HBTs) using a T-shaped emitter electrode has been developed. In this process, the T-shaped emitter electrode is used to allow the desired spacing between the emitter mesa and the base ohmic contact. The thickness of the emitter cap and emitter can be thinned independently of the base metal thickness. The thin emitter cap and emitter reduces the difference in characteristics due to the two emitter electrode orientations, parallel and perpendicular to orientation flat. A fabricated HBT shows a cutoff frequency (f/sub T/) of 98 GHz with a 0.9 /spl mu/m/spl times/4.7 /spl mu/m sub-micron emitter and a maximum f/sub T/ of 120 GHz with a 1.4 /spl mu/m/spl times/4.7 /spl mu/m emitter after it is embedded.
A Framework for Security Services Based on Software-Defined Networking (2015)

This paper proposes a framework for security services using Software-Defined Networking (SDN) and specifies requirements for such a framework. It describes two representative security services, such as (i) centralized firewall system and (ii) centralized DDoS-attack mitigation system. For each service, this paper discusses the limitations of legacy systems and presents a possible SDN-based system to protect network resources by controlling suspicious and dangerous network traffic that can be regarded as security attacks.
Functional analysis of a type IIB von Willebrand disease missense mutation: increased binding of large von Willebrand factor multimers to platelets. (1992)

Type IIB von Willebrand disease is an autosomal dominant bleeding disorder characterized by the selective loss of high molecular weight von Willebrand factor (vWF) multimers in plasma, presumably due to their abnormally increased reactivity with platelets. We and others have recently identified a panel of missense mutations clustered in the platelet glycoprotein Ib binding domain of vWF from patients with type IIB von Willebrand disease. We now report functional analysis of one of the most frequent type IIB missense mutations, Arg-543----Trp (vWF R543W). vWF from a human umbilical vein endothelial cell culture heterozygous for the vWF R543W mutation showed markedly increased binding of large vWF multimers to platelets in the presence of a low dose of ristocetin compared to vWF from a normal control culture. Recombinant vWF containing the vWF R543W mutation expressed in COS-7 cells also demonstrated increased binding of large vWF multimers. Mixed multimers obtained by cotransfection of mutant and wild-type cDNAs showed partial dominance of the vWF R543W mutation. Thus these data demonstrate that the vWF R543W mutation alone is sufficient to confer increased binding of large vWF multimers to platelets in a dominant fashion and that no other factors relating to vWF posttranslational processing or secretion in endothelial cells are required for this effect.
Comparison between laser scanning tomography and computerised image analysis of the optic disc (1999)

There was a significant discrepancy in the measurements of rim area and cup volume of the optic disc obtained by a computerised image analyser and a laser scanning tomograph.
The Release of Cytochrome c from Mitochondria during Apoptosis of NGF-deprived Sympathetic Neurons Is a Reversible Event (1999)

During apoptosis induced by various stimuli, cytochrome c is released from mitochondria into the cytosol where it participates in caspase activation. This process has been proposed to be an irreversible consequence of mitochondrial permeability transition pore opening, which leads to mitochondrial swelling and rupture of the outer mitochondrial membrane. Here we present data demonstrating that NGF-deprived sympathetic neurons protected from apoptosis by caspase inhibitors possess mitochondria which, though depleted of cytochrome c and reduced in size, remained structurally intact as viewed by electron microscopy. After re-exposure of neurons to NGF, mitochondria recovered their normal size and their cytochrome c content, by a process requiring de novo protein synthesis. Altogether, these data suggest that depletion of cytochrome c from mitochondria is a controlled process compatible with function recovery. The ability of sympathetic neurons to recover fully from trophic factor deprivation provided irreversible caspase inhibitors have been present during the insult period, has therapeutical implications for a number of acute neuropathologies.
Electroluminescence Properties of Systematically Derivatized Organic Chromophores Containing Electron Donor and Acceptor Groups (2002)

We present electroluminescent (EL) properties of new blue−green organic dyes. The molecular structures of these dyes are based on 2,7-divinyl-9,9-bis(tert-butyl)fluorene, a π-electron bridge, end-capped with electron donor (D) and/or electron acceptor (A) group(s) to form D−π−A, D−π−D, and A−π−A structures. The donor group is a triphenylamine, and the acceptor group is a diphenyloxadiazole. We studied EL properties of these dyes in a single-layer EL device having the following structure: ITO/PVK:DYE/Ca/Al. We found that both the wavelength of maximum emission and the threshold of EL depend on the structure and the concentration of the dye. Among the structure reported here, the D−π−A dye shows the highest EL performance, exhibiting a brightness of 498 cd/m2 at an applied voltage of 25 V.
Herbicide Resistance Traits in Maize and Soybean: Current Status and Future Outlook (2019)

This article reviews, focusing on maize and soybean, previous efforts to develop nontransgenic herbicide-resistant crops (HRCs), currently available transgenic HRC traits and technologies, as well as future chemical weed management options over the horizon. Since the mid twentieth century, herbicides rapidly replaced all other means of weed management. Overreliance on 'herbicide-only' weed control strategies hastened evolution of HR weed species. Glyphosate-resistant (GR) crop technology revolutionized weed management in agronomic crops, but GR weeds, led by Palmer amaranth, severely reduced returns from various cropping systems and affected the bottom line of growers across the world. An additional problem was the lack of commercialization of a new herbicide mode of action since the 1990s. Auxinic HRCs offer a short-term alternative for management of GR Palmer amaranth and other weed species. New HRCs stacked with multiple herbicide resistance traits and at least two new herbicide modes of action expected to be available in the mid-2020s provide new chemical options for weed management in row crops in the next decade.
Lac Repressor Inducible Gene Expression in Human Breast Cancer Cells In Vitro and in a Xenograft Tumor (1997)

We have studied the lac repressor (lacR) system in two breast cancer cell lines, MCF-7 and MDA-MB-231, in vitro and in vivo. Breast cancer cell lines were stably transfected with lacR and tested for inducibility by transient transfection with a lac operator/luciferase reporter plasmid. The level of expression of lacR did not appear to correlate with the basal or maximal activation of induction by isopropyl beta-D-thiogalactoside (IPTG). Stable transfection with the same reporter gene resulted in up to 40-fold (MDA-MB-231) and 50-fold (MCF7) induction. In the absence of IPTG, a low level of basal reporter gene expression was seen in all clones. Detailed analysis showed that induction was rapid (maximal at 24 h), reversible (a return to basal expression by 24 h) and dose-dependent. To test if this system was also inducible in vivo, cells were grown as a xenograft tumor in nude mice. Mice were given IPTG (0.53 mmol) by intraperitoneal injection, and the tumors were biopsied at several time points following administration. IPTG caused a 10-fold increase in luciferase activity after 8 h, which persisted for 24 h. Thus, this system allows tightly controlled inducible in vivo and in vitro gene expression with low basal expression, and it may provide an important tool for the study of lethal genes in human breast cancer cells.
Further Studies on the Immunogenicity of <i>Haemophilus influenzae</i> Type b and Pneumococcal Type 6A Polysaccharide-Protein Conjugates (1983)

Conjugates were prepared by carbodiimide-mediated coupling of adipic acid hydrazide derivatives of Haemophilus influenzae type b (Hib), Escherichia coli K100, and pneumococcal 6A (Pn6A) polysaccharides with tetanus toxoid (TT), as an example of a "useful" carrier, and horseshoe crab hemocyanin (HCH), as an example of a "nonsense" carrier. These conjugates were injected into NIH mice, and their serum antibody responses to the polysaccharides and proteins were characterized. As originally reported, Hib conjugates increased the immunogenicity of the capsular polysaccharide and elicited greater than the estimated protective levels of anti-Hib antibodies in most recipients after one injection and in all after the third injection (Schneerson et al., J. Exp. Med. 152:361-376, 1980). Both Hib conjugates induced similar anti-Hib responses. The K100-HCH conjugate was more immunogenic than the K100-TT conjugate and elicited anti-Hib responses similar to the Hib conjugates after the third injection. Simultaneous injection of the K100 and the Hib conjugates did not enhance the anti-Hib response. The Pn6A-TT conjugate induced low levels of anti-Hib antibodies; when injected simultaneously with the Hib conjugates, the anti-Hib response was enhanced, as all mice responded after the first injection and with higher levels of anti-Hib than observed with the Hib conjugates alone (P < 0.05). The Pn6A conjugates were not as immunogenic as the Hib conjugates. Pn6A-TT was more effective than was Pn6A-HCH; it elicited anti-Pn6A (>100 ng of antibody nitrogen per ml) in 6 of 10 mice after the third injection. The addition of the Hib-HCH conjugate to the Pn6A-TT conjugate increased the anti-Pn6A response with a higher geometric mean antibody titer, and 9 of 10 mice responded after the third injection. A preparation of diphtheria toxoid, TT, and pertussis vaccine increased the anti-Hib antibody levels after the first injection only in mice receiving Hib-TT, but not in mice receiving Hib-HCH, suggesting that additional carrier protein (TT) enhanced the anti-polysaccharide response. Simultaneous injection of Hib and Pn6A conjugates with the same or different carriers resulted in an enhanced serum antibody response to each polysaccharide. The anti-tetanus toxin response reached protective levels (>0.01 U/ml) in most mice after the first injection and in all mice after the second and third injections of TT conjugates. A progressive increase in the anti-HCH response with each additional injection was noted in animals receiving HCH conjugates. Animals receiving the diphtheria toxoid-TT-pertussis vaccine preparation responded with a greater increase in anti-carrier antibody than those receiving the conjugates alone. This method of synthesis provided conjugates capable of inducing protective levels of antibodies to both the polysaccharides and carrier proteins.
Leptospirosis (2005)

Major progress has been made in the basic research of leptospirosis. Future challenges will be to translate these advances into public health measures for developing countries. Yet the most effective responses may be interventions that directly address the determinants of poverty, such as poor sanitation, which are often responsible for transmission.
Prefix Assignment in DHCPv6 (2011)

This document describes a procedure for configuring a host's IPv6
address which prefix is allocated from a DHCPv6 server while it's
interface identifier is independently generated by the host. The
method is applicable to Cryptographically Generated Addresses (CGA).
IMMUNE DYSFUNCTION IN MURINE POLYMICROBIAL SEPSIS (1996)

Despite recent advances in antibiotic therapy, aggressive operative intervention and intravenous hyperalimentation, sepsis, and multiple organ failure are still reported to contribute to significant morbidity and mortality in the surgical intensive care unit. In light of this, it is essential to determine the mechanism underlying the pathophysiology of sepsis so that better therapeutic interventions can be designed. Experimental studies indicate that murine polymicrobial sepsis induces a marked suppression in both lymphocytic and macrophage function associated with decreased cellular adenosine triphosphate levels and increased Ca2+. However, such changes are not detectable until ∼12 h after the onset of sepsis. Alternatively, early (0–4 h) in sepsis, macrophages from the liver and peritoneum exhibit augmented innate secretion of proinflammatory cytokines, tumor necrosis factor, interleukin (IL)-6, and IL-1, associated with the systemic release of these agents. Sustained release of immunosuppressive agents transforming growth factor-β, IL-4, IL-10, and PGE2, as well as glucocorticoids, are also observed during sepsis. In this regard, many investigators, including us, have suggested that an agent(s) released as a part of this systemic inflammatory response to sepsis may be responsible for the protracted suppression of immune cell function. Studies examining the effects of these mediators in vitro on various immune cells have shown that many of these agents also have the capacity to induce a process referred to as programmed cell death (PCD) or apoptosis (Ao). We have presented evidence of marked changes in the rate of Ao in immune cells after the onset of sepsis. These data suggest the possibility that mediators released in response to septic insult contribute to the observed changes in immune cell function through the induction of Ao. Inasmuch, understanding the contribution of PCD to the pathophysiology of sepsis, should provide a better basis from which to develop more effective therapy for the septic patient.
Synthesis, Luminescence Properties, and Explosives Sensing with 1,1-Tetraphenylsilole- and 1,1-Silafluorene-vinylene Polymers (2007)

The syntheses, spectroscopic characterizations, and fluorescence quenching efficiencies of polymers and copolymers containing tetraphenylsilole- or silafluorene-vinylene repeat units are reported. These materials were prepared by catalytic hydrosilylation reactions between appropriate monomeric metallole alkynes and hydrides. Trimeric model compounds methyl(tetraphenyl)silole-vinylene trimer (1), methyl(tetraphenyl)silole-silafluorene-vinylene cotrimer (2), and methylsilafluorene-vinylene trimer (3) were synthesized to provide detailed structural and spectroscopic characteristics of the polymer backbone and to assess the extent of delocalization in the luminescent excited state. Poly(tetraphenylsilole-vinylene) (4), poly(tetraphenylsilole-silafluorene-vinylene) (5), and poly(silafluorene-vinylene) (6) maintain a regio-regular trans-vinylene Si−C backbone with possible ground state σ*−π and excited state σ*−π* conjugation through the vinylene bridge between metallole units. Fluorescence spectra of the polymers show an ∼13 nm bathochromic shift in λflu from their respective model compounds. Molecular weights (Mn) for these polymers and copolymers are in the range of 4000–4500. Detection of nitroaromatic explosives by solution-phase fluorescence quenching of polymers 4−6 was observed with Stern−Volmer constants in the range of 400−20 000 for TNT, DNT, and picric acid (PA). A surface detection method for the analysis of solid particulates of TNT, DNT, PA, RDX, HMX, Tetryl, TNG, and PETN is also described for silafluorene-containing polymers. Polymer 6 exhibited detection for all the preceding types of explosive residues with a 200 pg cm−2 detection limit for Tetryl. Polymers 4 and 5 exhibited only luminescence quenching with nitroaromatic explosives, revealing that the excited-state energy of the sensor plays a key role in the fluorescence detection of explosives.