gebhart/patrepeval huggingface dataset:
Some strains of serotype 4 fowl adenoviruses cause inclusion body hepatitis and hydropericardium syndrome in chickens (1998)

Fowl adenoviruses were isolated and characterized from severe cases of hydropericardium syndrome in Ecuador and Pakistan. All were neutralized by antibodies against serotypes 4 and 11. Cross-neutralization tests and restriction enzyme analysis strengthen the classification as serotype 4 strains. The restriction endonucleases used allowed the differentiation among field isolates and reference strains. All field isolates tested induced high embryo mortality. One-day-old specific pathogen free (SPF) chicks were infected with 10(5) plaque-forming units by natural routes to reproduce the disease with plaque purified virus. Whereas no mortality was seen with the reference strain, the mortality with the field isolates was 100%. A reduced mortality occurred with a lower infectious dose. Field isolate K1013 from Ecuador was also highly pathogenic for 1- to 3-week-old SPF chicks after intramuscular inoculation. The main pathological signs were swollen livers, severe hydropericardium and nephritis, reflecting the field situation and underlining the role of FAV4 strains in the aetiology of infectious hydropericardium.
Estimation and Performance Investigation on SLF Interrupting Ability of Puffer-Type Gas Circuit Breaker (1979)

Investigation of short line fault interrupting limits was conducted, making use of Mayr's equation considering the characteristic values of breaker, shunt capacitance and time delay of short line fault condition. The investigation led to a proposed effective method for estimating the interrupting ability of gas circuit breakers.
Combustion Chemistry (1987)

RETURN TO ISSUEPREVNewsNEXTCombustion ChemistryJAMES A. MILLER and GEORGE A. FISKView Author Information Sandia National LaboratoriesCite this: Chem. Eng. News 1987, 65, 35, 22–46Publication Date (Print):August 31, 1987Publication History Published online8 November 2010Published inissue 31 August 1987https://pubs.acs.org/doi/10.1021/cen-v065n035.p022https://doi.org/10.1021/cen-v065n035.p022newsACS PublicationsCopyright © 1987 American Chemical SocietyArticle Views32Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Redox reactions Get e-Alerts
A high programming throughput 0.35 μm p-channel DINOR flash memory (2002)

A high programming throughput p-channel DINOR flash memory with the BBHE injection programming method has been developed using 0.35 /spl mu/m CMOS process. This programming method realizes a high programming throughput of 8 nsec/Byte by utilizing 512 Byte parallel program operation with a low leakage current of less than 250 /spl mu/A. We have also demonstrated the good erase/write cycling endurance of 1/spl times/10/sup 5/. This process and device technology is very promising to the high performance 64 Mbit flash memories and future flash devices.
Mechanism of ozone generation in air-fed ozonisers (1979)

The mechanism of ozone generation in the silent discharge of air-fed ozonisers is studied theoretically and experimentally. The nitrogen oxides (NOx) formed in the silent discharge have been found to play an important role in the process of ozone generation due to the catalytic cycle for O3 destruction: NO+O3 to NO2+O2 and NO2+O to NO+O2. Taking this catalytic cycle into account, a mechanism is proposed to explain the characteristics of ozone generation in air-fed ozonisers. The electron impact dissociation coefficients of O2, N2 and O3 and the gas temperature in the silent discharge are estimated by the computer matching of the theoretical calculations to experimental results.
A very basic introduction to hearing aids (1983)

A hearing aid is designed to bring sounds, especially speech, more effectively to the ear of a person with hearing loss. Typically a person with sensorineural deafness has a raising of thresholds of hearing and the basic principles of how the aid may overcome the loss is described.
Delayed Skeletal Growth and Maturation in Adolescent Congenital Heart Disease (1970)

White, Robert I. Jr. MD; Jordan, Charles E. MD; Fischer, Keith BA; Nagy, Jerrold BA; Neill, Catherine MD; Garn, Stanley M. Phd; Dorst, John P. MD Author Information
ASIC for High Rate 3D Position Sensitive Detectors (2010)

We report on the development of an application specific integrated circuit (ASIC) for 3D position sensitive detectors (3D PSD). The ASIC is designed to operate with pixelated wide bandgap sensors like Cadmium-Zinc-Telluride (CZT), Mercuric Iodide (Hgl2) and Thallium Bromide (TIBr). It measures the amplitudes and timings associated with an ionizing event on 128 anodes, the anode grid, and the cathode. Each channel provides low-noise charge amplification, high-order shaping with peaking time adjustable from 250 ns to 12 μs, gain adjustable to 20 mV/fC or 120 mV/fC (for a dynamic range of 3.2 MeV and 530 keV in CZT), amplitude discrimination with 5-bit trimming, and positive and negative peak and timing detections. The readout can be full or sparse, based on a flag and single- or multi-cycle token passing. All channels, triggered channels only, or triggered with neighbors can be read out thus increasing the rate capability of the system to more than 10 kcps. The ASIC dissipates 330 mW which corresponds to about 2.5 mW per channel.
Web data management (2011)

Web Data Management (or WDM) refers to a body of work concerned with leveraging the large collections of structured data that can be extracted from the Web. Over the past few years, several research and commercial efforts have explored these collections of data with the goal of improving Web search and developing mechanisms for surfacing different kinds of search answers. This work has leveraged (1) collections of structured data such as HTML tables, lists and forms, (2) recent ontologies and knowledge bases created by crowd-sourcing, such as Wikipedia and its derivatives, DBPedia, YAGO and Freebase, and (3) the collection of text documents from the Web, from which facts could be extracted in a domain-independent fashion. The promise of this line of work is based on the observation that new kinds of results can be obtained by leveraging a huge collection of independently created fragments of data, and typically in ways that are wholly unrelated to the authors' original intent. For example, we might use many database schemas to compute a schema thesaurus. Or we might examine many spreadsheets of scientific data that reveal the aggregate practice of an entire scientific field. As such, WDM is tightly linked to Web-enabled collaboration, even (or especially) if the collaborators are unwitting ones. We will cover the key techniques, principles and insights obtained so far in the area of Web Data Management.
Molecular Design of Fluorescent Labeled Glycosides as Acceptor Substrates for Sialyltransferases (2010)

A series of dansyl-labeled glycosides with di-, tetra-, and hexasaccharides carrying the terminal N-acetyllactosamine (LacNAc) sequence were synthesized as acceptor substrates for α2,6- and α2,3-sialyltransferases. As an alternative design, dansyl-labeled LacNAc glycoside carrying a long-spacer linked glycan was engineered by replacement of the LacNAc or lactose units with an alkyl chain. In addition, we designed a dansyl-labeled bi-antennary LacNAc glycoside as an N-linked oligosaccharide mimetic, such as asialo-α(1)-acid glycoprotein. The kinetic parameters for the transfer reaction of synthesized dansyl-labeled glycosides by sialyltransferases were determined by the fluorescent HPLC method. The catalytic efficiencies (V(max)/K(m)) of acceptor substrates carrying the terminal LacNAc sequence with various length glycans in the array for α2,6- and α2,3-sialyltransferases decreased in a glycan length-dependent manner. Furthermore, of the acceptor substrates tested, dansyl-labeled bi-antennary LacNAc glycoside displayed the most favorable K(m) value for α2,6- and α2,3-sialyltransferases.
Donor–acceptor conjugated polymers based on thieno[3,2-b]indole (TI) and 2,1,3-benzothiadiazole (BT) for high efficiency polymer solar cells (2016)

Three conjugated polymers based on the thieno[3,2-<italic>b</italic>]indole (TI) unit as electron-donor block and benzothiadiazole (BT) as electron-accepting block and thiophene rings as spacers. Their photovoltaic performance were finely tuned by thiophene spacers.
Mobile phones: the next frontier for hackers? (2005)

Security experts are finding a growing number of viruses, worms, and Trojan horses that target cellular phones. Security researchers' attack simulations have shown that before long, hackers could infect mobile phones with malicious software that deletes personal data or runs up a victim's phone bill by making toll calls. The attacks could also degrade or overload mobile networks, eventually causing them to crash. And they could be even more insidious in the future by stealing financial data. Smart phones represent a particular risk. They offer Internet connectivity, function like minicomputers, and can download applications or files, some of which could carry malicious code. Mobile-device technology is still relatively new, and vendors have not developed mature security approaches. To counter the growing threat, antivirus companies have stepped up their research and development. In addition, vendors of phones and mobile operating systems are looking for ways to improve security.
Treatment of Post&ndash;Transfusion Graft&ndash;versus&ndash;Host Disease with Nafmostat Mesilate, a Serine Protease Inhibitor (1999)

This case indicates that administration of a serine protease inhibitor may improve PT-GVHD symptoms by inhibiting cytotoxic T-cell-mediated killing of target cells in fatal PT-GVHD. Steroids and monoclonal anti-CD3 were probably responsible for the transient clinical improvements. More studies are required, however, on mechanisms to eliminate the donor's lymphocytes.
43—The Geometry of a Plain Knitted Loop (1955)

This paper presents a geometrical model of a plain knitted loop as a basis for a mathematical description of the dimensional properties of a plain knitted fabric.
Pituitary-Adrenal Axis Regulation in Crh-Deficient Mice (2000)

Corticotropin-releasing hormone (CRH)-deficient (knockout (KO)) mice demonstrate severely impaired adrenal responses to restraint, ether, and fasting, and lack the normal diurnal glucocorticoid (GC) rhythm. Here, we summarize recent studies determining the role of CRH in augmenting plasma adrenocorticotrophic hormone (ACTH) concentration after glucocorticoid withdrawal and pituitary-adrenal axis stimulation in the context of inflammation. Even though GC insufficient, basal pituitary proopiomelanocortin (POMC) mRNA, ACTH peptide content within the pituitary, and plasma ACTH concentrations are not elevated in CRH KO mice. POMC mRNA content in CRH KO mice increases following adrenalectomy, and this increase is reversed by GC, but not aldosterone, replacement. In marked contrast to the increase in POMC mRNA, plasma ACTH does not increase in the CRH KO mice following adrenalectomy. Administration of CRH to adrenalectomized CRH KO mice results in acute, robust ACTH secretion. Thus, loss of GC feedback can increase POMC gene expression in the pituitary, but CRH action is essential for increased secretion of ACTH into the circulation. While GC secretion is impaired in CRH KO mice after most stimuli, we have found near-normal GC responses to inflammation and systemic immune challenge. Studies in mice with CRH and IL-6 deficiency reveal that IL-6 is essential for activation of the pituitary-adrenal axis during inflammatory and other stressors in the absence of CRH.
Time and frequency equalization in 802.11a/g (2004)

We study the BER performance of 802.11a/g in channels where the delay exceeds the cyclic prefix length. We find that a frequency equalizer (FEQ) designed from a time-domain estimate of the channel (TD-FEQ) out-performs the FEQ designed from a frequency domain estimate (FD-FEQ). Computer simulations show an 11 dB improvement. Secondly, the combination of a time equalizer (TEQ) and the TD-FEQ improves the BER compared with the TD-FEQ alone for higher transmission modes. For 64-QAM at E/sub b//N/sub o/ = 30 dB a 4.77 dB improvement is seen. The BER performance with different TEQ design criteria is examined.
Deletion of VAI and VAII RNA Genes in the Design of Oncolytic Adenoviruses (2006)

Deletion of viral functions that can be complemented by the specific phenotype of tumor cells is a common strategy to design oncolytic viruses. For example, enhanced mRNA cytoplasmic export in tumor cells phenocopies the adenovirus E1B-55K function and renders mutants of this protein tumor selective. Also, an activated RB pathway complements specific E1A functions that can be deleted to produce oncolytic viruses. In this paper we demonstrate that an adenoviral mutant deleted in virus-associated I (VAI) and VAII RNAs (Ad-VAdel) has oncotropism characterized by 100-fold replication deficiency compared with wild-type adenovirus in normal cells and an unaffected ability to replicate and kill different types of tumor cells. This mutant also displays active antitumoral activity in vivo. In contrast, this oncotropism is less evident in a mutant expressing an inactive form of VAI (Adsub719) because VAII RNA expression is upregulated. The mRNA translation promoted by VA RNA genes can be phenocopied in tumor cells with the activation of signal transduction pathways, such as the Ras pathway.
Low 1 <i>/f</i> noise SiGe HBTs with applicationto low phase noise microwave oscillators (1997)

SiGe HBTs featuring a high quality oxide passivation show ideal Gummel plots and low 1/f noise with corner frequencies down to 300 Hz. The measured KB-factor of 2.6 × 10–10 µm2s is the lowest of any previously reported HBT. With an f⊤ of 40 GHz, the devices are ideal for low phase noise microwave oscillators. A simple 10 GHz microstrip resonator showed –100 dBc at 100 kHz off carrier.
Production and Characterization of Monoclonal Antibodies against Two Haptenic Derivatives of 1.ALPHA.,25-Dihydroxyvitamin D3 Conjugated with Bovine Serum Albumin through the C-3 or C-24 Position. (1997)

To develop the immunochemical methods for determining 1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3] in clinical samples, a variety of monoclonal anti-1,25(OH)2D3 antibodies have been generated. Two kinds of hapten-carrier conjugates, 25-hydroxyvitamin D3 3-hemisuccinate (hapten 3-HS) and 1 alpha-hydroxy-25,26,27-trinorvitamin D3 24-oic acid (hapten 24-OA) conjugated with bovine serum albumin, were used for immunization. Spleen cells from SD rats or BALB/c mice, each immunized with the conjugate of hapten 3-HS or 24-OA, were fused with P3/NS1/1-Ag4-1 myeloma cells. After screening by ELISA employing beta-galactosidase-labeled haptens, seven kinds of hybridomas secreting anti-1,25(OH)2D3 antibodies were established. Binding characteristics of these antibodies (Ka 0.73-20 x 10(9) M-1) were investigated by an RIA using tritium-labeled 1,25(OH)2D3. The data suggested that the rat monoclonal antibody 3R-1 derived from the hapten 3-HS and the mouse monoclonal antibody 24M-3 from the hapten 24-OA would be available for developing practical analytical systems.
Catalytic Ozonation of Toluene Using Zeolite and MCM-41 Materials (2008)

The effects of passing ozone over different zeolite and MCM-41 materials to remove toluene were investigated. Different ozone-to-toluene ratios were used to evaluate the catalytic performance during ozonation. The micro- and meso-porous materials removed about 50% of the toluene via adsorption and another 20-40% was decomposed by ozonation, which was catalytically enhanced by the zeolite and MCM-41 materials. The catalytic reaction portion increased by using a higher ozone inlet concentration and it was further enhanced to around 50% with the use of more adsorbents or with longer residence times. Inside the porous structure of the material, ozone was either decomposed into active atomic oxygen for reactions or converted into oxygen for active site regeneration. The number of Lewis acid sites in the adsorbents for ozone decomposition and byproduct generation during the reactions limit the catalytic activities. Trace amounts of intermediates including aldehydes and organic acids were quantified in the ozonation process. A higher ozone inlet concentration helped to reduce intermediate species formation but it led to more residual ozone in the exhaust. The high adsorption capability of the zeolite and MCM-41 adsorbents could serve as reservoirs for suppressing the release of intermediate species to the exhaust.
Comparison of Antiplaque Agents Using an In Vitro Assay Reflecting Oral Conditions (1977)

An in vitro assay is described using saliva-treated bovine enamel slabs for determining the potential of chemotherapeutic agents to adsorb to tooth surfaces and act against plaque-forming bacteria. Chlorhexidine was found to inhibit the formation of in vitro plaque by Actinomyces viscosus, A naeslundii, Streptococcus mutans and S sanguis. Actinobolin was found to have marked antibacterial properties but limited adsorptive qualities.
Hydrogen Confinement in Carbon Nanopores: Extreme Densification at Ambient Temperature (2011)

In-situ small-angle neutron scattering studies of H(2) confined in small pores of polyfurfuryl alcohol-derived activated carbon at room temperature have provided for the first time its phase behavior in equilibrium with external H(2) at pressures up to 200 bar. The data were used to evaluate the density of the adsorbed fluid, which appears to be a function of both pore size and pressure and is comparable to the density of liquid H(2) in narrow nanopores at ∼200 bar. The surface-molecule interactions responsible for densification of H(2) within the pores create internal pressures that exceed the external gas pressure by a factor of up to ∼50, confirming the benefits of adsorptive storage over compressive storage. These results can be used to guide the development of new carbon adsorbents tailored for maximum H(2) storage capacities at near-ambient temperatures.
Safety, pharmacology, and preliminary clinical activity of MM-151: An oligocolnal anti-EGFR theraputic in patients with cetuximab-resistant CRC and other refractory solid tumors. (2015)

647 Background: MM-151 is an oligoclonal anti-EGFR antibody combination designed to provide enhanced targeting of the EGFR network. This work describes the first in human experience of MM-151 alone and in combination with irinotecan. Methods: A standard 3+3 design was used to assess safety and tolerability of MM-151 monotherapy (QW, Q2W, Q3W) and MM-151 (QW) in combination with irinotecan 180mg/m2 (Q2W). A monotherapy expansion cohort has begun in cetuximab-resistant CRC. Results: Results presented are based on preliminary data as of September 2, 2014, for MM-151 monotherapy (n=65; QW/Q2W) and MM-151 in combination with irinotecan (n=10). The most common tumor types were CRC (29 [39%]), NSCLC (9 [12%]), HNSCC (8 [11%]). The monotherapy RP2D has been defined as 10.5 mg/kg QW and dosing continues at 18 mg/kg Q2W. Most adverse events were CTCAE grades 1 and 2. The most common AEs were toxicities related to the EGFR-pathway, including rash (70%), hypomagnesemia (24%), fatigue, dry skin, and diarrhea (21%). IRR was initially observed at high frequencies; however, standardized pre-medication and a modified infusion schedule significantly decreased this frequency. At doses >9 mg/kg QW, trough total antibody levels at steady state were in the expected therapeutic range. Of the CRC patients enrolled, 3 experienced Partial Responses (PRs) per RECIST criteria and a total of 8 (31%) pts had SD for >4 months. Initial biomarker data suggests particular clinical activity in triple-wildtype, EGFR-ligand positive CRC patients. Combination therapy with irinotecan continues with MM-151 at 9 mg/kg QW and 3 PRs have been observed (CRC, HNSCC, melanoma). Initial safety data is consistent with known toxicities of MM-151 and irinotecan. Preliminary results from the monotherapy expansion cohort (10.5 mg/kg QW) in CTX-refractory CRC will also be presented. Conclusions: These results demonstrate that MM-151 monotherapy has an acceptable tolerability profile and objective clinical activity alone and in combination with irinotecan. Results also support further clinical evaluation in triple-wildtype, EGFR-ligand positive CRC and other EGFR dependent cancers. Clinical trial information: NCT01520389.
77 GHz soliton modelocked Nd:YVO <sub>4</sub> laser (2000)

An Nd:YVO4 laser which was passively modelocked at the very high repetition rate of ~77 GHz, using a semiconductor saturable absorber mirror (SESAM), is demonstrated. The soliton-like pulses are well separated in time and their duration is 2.7 ps. The required negative dispersion is introduced by a GTI-like structure, which is formed by the gain medium and the SESAM.
Variabilidade na produção em progênies do cafeeiro 'Mundo Novo' (1984)

Quinze progênies S1 do cultivar Mundo Novo de Coffea arabica L. foram plantadas em Campinas em 1944 para fins de seleção. As produções de cada cafeeiro foram anotadas por 37 anos consecutivos (1946/82), a fim de avaliar a sua capacidade produtiva. Verificou-se acentuada variabilidade na produção total, tanto entre as plantas da mesma progênie como entre as diferentes progênies. As maiores produções totais referem-se às progênies CP 376, CP 386, CP 379, CP 387 e CP 382, independentemente das falhas apresentadas. Algumas das plantas vêm, ainda, apresentando boas produções, porém a maioria teve a maior produção do 16° ao 18° ano. O número de falhas começou a acentuar-se a partir da 23ª produção anual e aumentou até a 34ª. As falhas atingiram 15% para a progênie CP 379, 55% para as progênies CP 388 e CP 381, e 60% para a CP 382. As demais apresentaram valores intermediários. Novas seleções foram realizadas dentre os cafeeiros mais promissores das melhores progênies, a fim de testá-los em várias localidades, avaliar a sua capacidade produtiva e confirmar a sua longevidade.
Distributed retransmission controls for slotted, nonpersistent, and virtual time CSMA (1988)

A class of distributed retransmission controls based on stochastic approximation techniques is developed for the infinite-population, slotted, nonpersistent, and virtual-time CSMA channels. These controls, which permit each terminal to adjust its retransmission probability in a simple, recursive manner as a function of channel feedback, are stable in terms of the geometric ergodicity of an imbedded Markov chain model for each channel. Simulation results demonstrate the effectiveness of the controls in supporting stable channel operation at maximum achievable throughput, recovering from an abrupt arrival of a larger number of new packets, and providing delay versus throughput performance that closely approximates that of an idealized channel in which each terminal has perfect knowledge of the number of blocked (collided) terminals.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>