gebhart/patrepeval huggingface dataset:
Characterization of Spiral Inductors With Patterned Floating Structures (2004)

The impact of two different types of floating patterns on spiral inductors was investigated. Both patterned trench isolation with a floating p/n junction and floating metal poles were implemented underneath reference spiral inductors. All three types of inductors have an identical spiral geometry. Combination of patterned trench isolation with a floating p/n junction increases maximum quality factor (Q/sub max/) by 17% compared to the reference inductors. The floating metal poles enable adjustment of the frequency at Q/sub max/ (f/sub max/) without hampering the Q/sub max/. A ladder-type lump-element model was employed to analyze inductor performance after it was demonstrated to precisely capture behavior of all three inductors. Enhancement of the quality factor due to patterned trench isolation with a floating p/n junction was found to result from an increment of effective resistivity in substrates. Reduction of the frequency f/sub max/ due to the floating metal poles was caused by increasing effective coupling capacitance between the spiral inductors and substrate.
Learning to identify emotions in text (2008)

This paper describes experiments concerned with the automatic analysis of emotions in text. We describe the construction of a large data set annotated for six basic emotions: ANGER, DISGUST, FEAR, JOY, SADNESS and SURPRISE, and we propose and evaluate several knowledge-based and corpusbased methods for the automatic identification of these emotions in text.
Multiagent cooperation and competition with deep reinforcement learning (2017)

Evolution of cooperation and competition can appear when multiple adaptive agents share a biological, social, or technological niche. In the present work we study how cooperation and competition emerge between autonomous agents that learn by reinforcement while using only their raw visual input as the state representation. In particular, we extend the Deep Q-Learning framework to multiagent environments to investigate the interaction between two learning agents in the well-known video game Pong. By manipulating the classical rewarding scheme of Pong we show how competitive and collaborative behaviors emerge. We also describe the progression from competitive to collaborative behavior when the incentive to cooperate is increased. Finally we show how learning by playing against another adaptive agent, instead of against a hard-wired algorithm, results in more robust strategies. The present work shows that Deep Q-Networks can become a useful tool for studying decentralized learning of multiagent systems coping with high-dimensional environments.
Signal design for good correlation for wireless communication, cryptography, and radar (2005)

This book provides a comprehensive, up-to-date description of the methodologies and the application areas, throughout the range of digital communication, in which individual signals and sets of signals with favorable correlation properties play a central role. The necessary mathematical background is presented to explain how these signals are generated, and to show how they satisfy the appropriate correlation constraints. All the known methods to obtain balanced binary sequences with two-valued autocorrelation, many of them only recently discovered, are presented in depth. The authors treat important application areas including: Code Division Multiple Access (CDMA) signals, such as those already in widespread use for cell-phone communication, and planned for universal adoption in the various approaches to 'third-generation'(3G) cell-phone use; systems for coded radar and sonar signals; communication signals to minimize mutual interference ('cross-talk') in multi-user environments; and pseudo-random sequence generation for secure authentication and for stream cipher cryptology
Overview, prevention and management of chemotherapy extravasation (2016)

Chemotherapy extravasation remains an accidental complication of chemotherapy administration and may result in serious damage to patients. We review in this article the clinical aspects of chemotherapy extravasation and latest advances in definitions, classification, prevention, management and guidelines. We review the grading of extravasation and tissue damage according to various chemotherapeutic drugs and present an update on treatment and new antidotes including dexrazoxane for anthracyclines extravasation. We highlight the importance of education and training of the oncology team for prevention and prompt pharmacological and non-pharmacological management and stress the availability of new antidotes like dexrazoxane wherever anthracyclines are being infused.
Sildenafil Prevents Change in RhoA Expression Induced by Chronic Hypoxia in Rat Pulmonary Artery (2003)

Exposure to chronic hypoxia (CH) induces a sustained pulmonary hypertension associated with structural and functional changes in the pulmonary arterial bed, including alterations of contractile properties. The small G-protein RhoA and its effector Rho kinase play a major role in the sustained rise in tension induced by vasoconstrictors. The aim of this study was to analyze the effect of CH on the RhoA/Rho kinase signaling pathway in the rat pulmonary artery. Maximal contraction of pulmonary artery rings to endothelin-1, noradrenaline, and the thromboxane A2 analog U46619 was markedly decreased in rats exposed to CH (10% O2, 2 weeks). This CH-induced decrease response to agonists was attributable to the abolition of RhoA-mediated Ca2+ sensitization of the contraction. Real-time reverse transcriptase-polymerase chain reaction and Western blot analysis revealed a decrease in RhoA mRNA (79.4+/-6.0%, n=4) and RhoA (81.1+/-8.0%, n=4) expression in the main pulmonary artery from CH rats, whereas RhoA expression was not modified in arterial smooth muscle cells and arteries exposed to hypoxia and high intraluminal pressure, respectively. Treatment of rats with sildenafil (25 mg/kg per day) throughout 2 weeks of exposure to CH prevented CH-induced downregulation of RhoA, reduction of contraction, and pulmonary artery remodeling. These findings indicate that CH-induced downregulation of RhoA expression, leading to the abolition of RhoA/Rho kinase-mediated Ca2+ sensitization of contraction, is responsible for the decreased responses to contracting agonists in the pulmonary artery of CH rats. These alterations are prevented by sildenafil, indicating a major role of the NO/cyclic GMP pathway in CH-induced altered RhoA signaling in the pulmonary artery.
Optimizing leaf widths for a multileaf collimator (2009)

The multileaf collimator (MLC) is becoming a standard accessory of modern linac in shaping radiation fields. However, for a given target (projection), the radiation field shaped by an MLC has a stepwise boundary and is not identical to the desired field that exactly conforms to the target. That means there are always under-blocked and/or over-blocked areas. The total area of discrepancy depends on MLC leaf widths. The purpose of this study is to develop an optimization model for determining leaf widths so that the total area of discrepancy between MLC-shaped fields and the desired ones can be minimized. The optimization model regards leaf widths as variables, the total area of discrepancy between MLC-shaped fields and the desired fields as an objective function, and the total width of all leaves as a constraint. A problem described by the model is solved with the hybrid of a simulated annealing technique (ASA, Lester Ingber, 1993) and a gradient technique (DONLP2, P Spellucci, 2001). The performance of the optimization model was evaluated on 634 target fields continuously selected from the patient database of a treatment planning system. The lengths of these fields ranged from 3.9 to 38.7 cm and had an average of 15.3 cm. The total area of discrepancy was compared between an MLC with optimal leaf widths and a conventional MLC with the same number of leaf pairs. Optimal leaf widths were obtained for an MLC with total leaf pairs of 28, 40 and 60, respectively, which corresponded to three types of conventional MLCs. The optimal leaf width first decreases slightly and then nonlinearly increases with the distance away from the central line. Compared with the MLC with conventional leaf width arrangement, the MLCs with optimal leaf width arrangement reduced the total area of discrepancy by 11.1%, 28.6% and 25.0%, respectively. Optimizing leaf widths can either improve the conformity of MLC-shaped fields to the treatment targets when the number of leaf pairs does not change, or reduce the number of leaf pairs without sacrifice of field conformity.
Methylation of Chitosan with Iodomethane: Effect of Reaction Conditions on Chemoselectivity and Degree of Substitution (2003)

Abstract N , N , N ‐trimethylchitosan (TMC) was prepared by reacting purified chitosan with iodomethane, in the presence of sodium hydroxide, water and sodium iodide, at room temperature. The reaction medium was N ‐methyl‐2‐pyrrolidone. Different samples of TMC were obtained by adding to the reaction medium a fixed volume (5.5 mL) of aqueous NaOH solutions at different concentrations (15, 20, 30 and 40 wt.‐%) and carrying out the reactions for 9 or 24 h. The features observed in the 1 H and 13 C NMR spectra of these chitosan derivatives, in respect of the chemical shift, number and relative intensity of the signals, depended strongly on the excess of NaOH and H 3 CI added to the reaction medium, but when the lowest excess was employed, the characteristics of the derivative were not affected by the reaction time to the same extent. The average degree of quaternization of these N ‐methylated derivatives of chitosan ranged from 10.5% to 44.8%, according to the reaction conditions. Increasing the excess of NaOH, in reactions carried out for 9 h, resulted in TMC samples with progressively higher content of trimethylated sites however, the reaction yields were correspondingly lower and O ‐alkylation was favored in these cases. 1 H NMR spectrum of sample [A X ] 24h dissolved in D 2 O ( C p = 10 g/L). magnified image 1 H NMR spectrum of sample [A X ] 24h dissolved in D 2 O ( C p = 10 g/L).
Methods for bounding end-to-end delays on an AFDX network (2006)

Architectures of avionics networks, such as that of the Airbus A380, currently know important evolutions. This is principally due to the increase in the complexity of the embedded systems, in term of rise in number of integrated functions and their connectivity. The evolution of switched Ethernet technologies allows their implementation as an avionics architecture (AFDX: avionics full duplex switched Ethernet). The problem is then to prove that no frame is lost by the network (no switch queue will overflow) and to evaluate the end-to-end transfer delay through the network. The objective of this paper is to present and shortly compare three methods for the evaluation of end-to-end delays: network calculus, queuing networks simulation and model checking
The sound of light (2013)

This paper presents a novel approach to assist users of digital cameras and augment their photograph taking experience. To this end, a realtime analysis of the images framed by the camera is conducted to assess composition, exposure and presence of human subjects. The resulting information is used to give users feedback about their photographs before they release the shutter. The main contribution of this paper is the use of synesthetic feedback: a musical composition that maps aspects resulting from the realtime analysis of images is composed and played back to the photographer. A preliminary study shows that musical attributes can be controlled to provide effective feedback about the visual modality.
Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells. (1990)

We have studied the roles of 5,10-methylenetetrahydrofolate (5,10-methylene-H4PteGlu) depletion and dihydrofolate (H2PteGlu) accumulation in the inhibition of de novo thymidylate synthesis by methotrexate (MTX) in human MCF-7 breast cancer cells. Using both a high pressure liquid chromatography system and a modification of the 5-fluoro-2'-deoxyuridine-5'-monophosphate radioenzymatic binding assay, we determined that the 5,10-methylene-H4PteGlu pool is 50-60% depleted in human MCF-7 breast cancer cells following exposure to 1 micron MTX for up to 21 h. Similar alterations in the 5,10-methylene-H4PteGlu pools were obtained when human promyelocytic HL-60 leukemia cells and normal human myeloid precursor cells were incubated with 1 micron MTX. The H2PteGlu pools within the MCF-7 cells increased significantly after 15 min of 1 micron MTX exposure, reaching maximal levels by 60 min. Thymidylate synthesis, as measured by labeled deoxyuridine incorporation into DNA, decreased to less than 20% of control activity within 30 min of 1 micron MTX exposure. The inhibition of thymidylate synthesis coincided temporally with the rapid intracellular accumulation of H2PteGlu, a known inhibitor of thymidylate synthase. Furthermore, inhibition of this pathway was associated in a log-linear fashion with the intracellular level of dihydrofolate. These studies provide further evidence that depletion of the thymidylate synthase substrate 5,10-methylene-H4PteGlu is inadequate to account completely for diminished thymidylate synthesis resulting from MTX treatment. Our findings suggest that acute inhibition of de novo thymidylate synthesis is a multifactorial process consisting of partial substrate depletion and direct enzymatic inhibition by H2PteGlu polyglutamates.
Optical-Resolution Photoacoustic Microscopy Using Transparent Ultrasound Transducer (2019)

The opacity of conventional ultrasound transducers can impede the miniaturization and workflow of current photoacoustic systems. In particular, optical-resolution photoacoustic microscopy (OR-PAM) requires the coaxial alignment of optical illumination and acoustic-detection paths through complex beam combiners and a thick coupling medium. To overcome these hurdles, we developed a novel OR-PAM method on the basis of our recently reported transparent lithium niobate (LiNbO<sub>3</sub>) ultrasound transducer (Dangi et al., Optics Letters, 2019), which was centered at 13 MHz ultrasound frequency with 60% photoacoustic bandwidth. To test the feasibility of wearable OR-PAM, optical-only raster scanning of focused light through a transducer was performed while the transducer was fixed above the imaging subject. Imaging experiments on resolution targets and carbon fibers demonstrated a lateral resolution of 8.5 µm. Further, we demonstrated vasculature mapping using chicken embryos and melanoma depth profiling using tissue phantoms. In conclusion, the proposed OR-PAM system using a low-cost transparent LiNbO<sub>3</sub> window transducer has a promising future in wearable and high-throughput imaging applications, e.g., integration with conventional optical microscopy to enable a multimodal microscopy platform capable of ultrasound stimulation.
Multi-conditional learning: generative/discriminative training for clustering and classification (2006)

This paper multi-conditional learning (MCL) a training criterion based on a product of multiple conditional likelihoods. When combining the traditional conditional probability of "label given input" with a generative probability of "input given label" the later acts as a surprisingly effective regularizer. When applied to models with latent variables, MCL combines the structure-discovery capabilities of generative topic models, such as latent Dirichlet allocation and the exponential family harmonium, with the accuracy and robustness of discriminative classifiers, such as logistic regression and conditional random fields. We present results on several standard text data sets showing significant reductions in classification error due to MCL regularization, and substantial gains in precision and recall due to the latent structure discovered under MCL.
One-dimensional deterministic transport in neurons measured by dispersion-relation phase spectroscopy (2011)

We studied the active transport of intracellular components along neuron processes using a new method developed in our laboratory: dispersion-relation phase spectroscopy. This method is able to quantitatively map spatially the heterogeneous dynamics of the concentration field of the cargos at submicron resolution without the need for tracking individual components. The results in terms of density correlation function reveal that the decay rate is linear in wavenumber, which is consistent with a narrow Lorentzian distribution of cargo velocity.
[Cyproterone acetate improves beta-cell function in postmenopausal women with diabetes mellitus type 2]. (2003)

Menopause is associated with two main risk factors for the development of type 2 diabetes mellitus--impaired beta-cell insulin secretion and insulin resistance. Physiologically estrogens improve carbohydrate metabolism, but this is not the case with different progestogens. The aim of the present study was to evaluate the effect of Cyproterone acetate (a progestogen with antiandrogenic activity) on insulin secretion, peripheral insulin sensitivity, lipid parameters and parameters of oxidative stress. Seven type 2 diabetic females, of mean age 55.4 +/- 4.7 years and mean BMI 30.8 +/- 9.39 kg/m2, in menopause for average 5 years, in good borderline glycaemic control (mean HbAic 7.8%), with dyslipidaemia, normal parameters of calcium and phosphate metabolism and with osteopenia (T-score < 88%) were enrolled in the study. They were treated with Estradiol valerate + Cyproterone acetate (Climen, Schering) for three months. Phases of insulin secretion--first phase (FPIS), second phase (SPIS) and AUC for FPIS and SPIS were assessed during IVGTT. Insulin sensitivity was determined with the manual method of euglycaemic hyperinsulinaemic clamp technique. The postmenopausal diabetic women in the present study were with overweight and obesity; they did not increase their body weight during HRT and even decreased it by mean 0.7%. Insulin secretion improved after Climen--FPIS increased by 16% and SPIS by 44%. Insulin sensitivity increased by 15%; triglycerides decreased by 16% and HDL-cholesterol increased by 27%. Total antioxidant capacity of the serum (TAOK) increased by 7%. The favourable effect on the pathophysiological mechanisms improved metabolic control--HbAic was reduced by mean 3% after 3 months. In conclusion, our results suggest that HRT with the progestogen Cyproterone acetate (Climen) should be preferred in postmenopausal type 2 diabetic females with predominant beta-cell insulin secretion defect.
Riboswitch RNAs: using RNA to sense cellular metabolism (2008)

Riboswitches are RNA elements that undergo a shift in structure in response to binding of a regulatory molecule. These elements are encoded within the transcript they regulate, and act in cis to control expression of the coding sequence(s) within that transcript; their function is therefore distinct from that of small regulatory RNAs (sRNAs) that act in trans to regulate the activity of other RNA transcripts. Riboswitch RNAs control a broad range of genes in bacterial species, including those involved in metabolism or uptake of amino acids, cofactors, nucleotides, and metal ions. Regulation occurs as a consequence of direct binding of an effector molecule, or through sensing of a physical parameter such as temperature. Here we review the global role of riboswitch RNAs in bacterial cell metabolism.
1.31-1.55-μm phased-array demultiplexer on InP (1996)

The first demultiplexers on InP at 1.31-1.55 μm based on low-order waveguide arrays have been fabricated and characterized. We show the calculated and measured spectral responses of two devices with 6 and 10 waveguides in the grating. The on-chip loss of the devices is 4.5 dB and the crosstalks are down to -25 dB. Thanks to their large bandwidth, the devices are polarization insensitive and no strong influence of the temperature is seen.
Operating principles of bipolar transistor magnetic sensors (1984)

Dual-collector bipolar transistor structures have been evaluated and found to be sensitive to an applied magnetic field. In particular, the magnetic field results in unequal currents to the two collectors. The output signal is taken as a differential voltage developed across the output load resistors. The mechanism giving rise to the unequal collector currents appears to be emitter-injection modulation caused by the applied magnetic field. The magnetic field causes the injection from one portion of the emitter to be enhanced while suppressing injection elsewhere thus setting up unequal currents to the two collectors. A simplified theory is presented to explain the behavior of these devices. The theory is found to be in general agreement with experimental results obtained from a number of different device configurations.
Characterization and expression profiles of miRNAs in rice seeds (2008)

Small RNAs (sRNAs) are common and effective modulators of gene expression in eukaryotic organisms. To characterize the sRNAs expressed during rice seed development, massively parallel signature sequencing (MPSS) was performed, resulting in the obtainment of 797,399 22-nt sequence signatures, of which 111,161 are distinct ones. Analysis on the distributions of sRNAs on chromosomes showed that most sRNAs originate from interspersed repeats that mainly consist of transposable elements, suggesting the major function of sRNAs in rice seeds is transposon silencing. Through integrative analysis, 26 novel miRNAs and 12 miRNA candidates were identified. Further analysis on the expression profiles of the known and novel miRNAs through hybridizing the generated chips revealed that most miRNAs were expressed preferentially in one or two rice tissues. Detailed comparison of the expression patterns of miRNAs and corresponding target genes revealed the negative correlation between them, while few of them are positively correlated. In addition, differential accumulations of miRNAs and corresponding miRNA*s suggest the functions of miRNA*s other than being passenger strands of mature miRNAs, and in regulating the miRNA functions.
Relative potencies of four reference endotoxin standards as measured by the Limulus amoebocyte lysate and USP rabbit pyrogen tests (1980)

Four commonly used reference endotoxin standards, Escherichia coli O113:H10:K0, E. coli O55:B5, Salmonella abortusequi, and Shigella dysenteriae were compared by the USP rabbit pyrogen and the Limulus amoebocyte lysate tests. By the rabbit pyrogen test, S. abortus equi was identified as the most potent endotoxin, followed closely by E. coli O113:H10:K0 and E. coli O55:B5.