gebhart/patrepeval huggingface dataset:
Antibacterial Networks Based on Isosorbide and Linalool by Photoinitiated Process (2015)

In this study, we used photo-induced thiol-ene reactions to design bio-based cross-linked networks from diallyl derivative isosorbide, a crude monoterpene as linalool and a trithiol. The aim of this study is to prepare new antibacterial UV-cured networks by using a thiol-ene formulation with covalent immobilization of monoterpenes as antibacterial agents and without any organic solvent thanks to the solvent-like properties of linalool. The challenge was to demonstrate the advantage of using linalool as a chemical platform molecule and, at the same time, as an antibacterial agent. The incorporation of linear linalool to the rigid isosorbide moiety generates flexible networks. Different networks were prepared by varying the mass ratio of linalool (from 0 to 100% w/w) mixed into the coating and then characterized. Their antibacterial activities were investigated in vitro against two pathogenic bacteria strains: Escherichia coli and Staphylococcus aureus. The results have shown a promising antiadherence for S. aureus without any diffusion of linalool that will allow potential applications of terpenes coatings for antibacterial adhesion.
Regulation of Food Intake Through Hypothalamic Signaling Networks Involving mTOR (2008)

To maintain normal activity, single cells must assure that their energy needs and utilization are continuously matched. Likewise, multicellular organisms must constantly coordinate energy intake and expenditure to maintain energy homeostasis. The brain, and the hypothalamus in particular, plays a critical role in integrating and coordinating several types of signals, including hormones and nutrients, to guarantee such homeostasis. Like single cells, the hypothalamus also profits from intracellular pathways known to work as fuel sensors to maintain energy balance. One such pathway is the mammalian target of rapamycin (mTOR). mTOR integrates different sensory inputs to regulate protein synthesis rates in individual cells, and it has recently been implicated in the central nervous system to regulate food intake and body weight as well. This review provides an overview of the role of hypothalamic intracellular fuel sensors in the overall control of energy balance and discusses the potential contribution of these fuel-sensing mechanisms to the metabolic dysregulation associated with obesity.
Influence of Epitaxial Growth and Substrate Induced Defects on the Breakdown of High-voltage 4H-SiC Schottky Diodes (2000)

The influence of morphological and structural defects on high-voltage 4H-SiC Schottky diodes was studied. Micropipes were found as severely limiting the breakdown voltage of 4H-SiC power devices, where as carrot-like defects did not influence the value of breakdown voltage. The screw dislocation density as determined by X-ray topography analysis under the active area of the diode was also found to directly affect the breakdown voltage value. Only diodes with low density of screw dislocations and free from micropipes could block 2 kV or higher.
Routine dual-wavelength analysis of anticonvulsant drugs by high-performance liquid chromatography. (1977)

Journal Article Routine dual-wavelength analysis of anticonvulsant drugs by high-performance liquid chromatography. Get access S J Soldin, S J Soldin Search for other works by this author on: Oxford Academic Google Scholar J G Hill J G Hill Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 23, Issue 12, 1 December 1977, Pages 2352–2353, https://doi.org/10.1093/clinchem/23.12.2352 Published: 01 December 1977
Orphan LuxR regulators of quorum sensing (2009)

Bacteria can modulate their behavior by releasing and responding to the accumulation of signal molecules. This population co-ordination, referred to as quorum sensing, is prevalent in Gram-negative and Gram-positive bacteria. The essential constituents of quorum-sensing systems include a signal producer, or synthase, and a cognate transcriptional regulator that responds to the accumulated signal molecules. With the availability of bacterial genome sequences and an increased elucidation of quorum-sensing circuits, genes that code for additional transcriptional regulators, usually in excess of the synthase, have been identified. These additional regulators are referred to as 'orphan' regulators, because they are not directly associated with a synthase. Here, we review orphan regulators characterized in various Gram-negative bacteria and their role in expanding the bacterial regulatory network.
An Improved Method for Extracting Cell-Free Herpesviruses of Marek's Disease and Turkeys from Infected Cell Cultures (1978)

Sonic extraction of cell-free Marek's disease herpesvirus (MDHV) and turkey herpesvirus (HVT) from infected cell cultures was improved by incorporating sorbitol in the suspending media. Yields of cell-free virus of virulent MDHV were significantly increased with 10% sorbitol added to SPGA-EDTA buffer. Avirulent strains of MDHV and HVT were respectively readily extracted with SPGA-EDTA and SPGA as the suspending medium, and extraction of their cell-free viruses was moderately improved by adding sorbitol to the suspending medium.
Predicting Cancer Progression in Patients With Stage T1 Bladder Carcinoma (1999)

The depth of invasion in the TURB specimens, measured with a micrometer, is predictive of cancer progression in patients with stage T1 bladder carcinoma.
Compression with reversible embedded wavelets with an enhanced binary mode (2002)

Compression with reversible embedded wavelets (CREW) is a unified lossless and lossy continuous-tone still image compression system. Wavelet coefficients are encoded in a bit-significance embedded order, allowing lossy compression by truncating the compressed data after encoding. CREW's context-based coding, called Horizon coding, takes advantage of the spatial and spectral information available in the wavelet domain and adapts well to the lessor significant bits. CREW's capabilities have been enhanced to include a binary mode for compression of binary and graphic images. This also improves compression on some images that do not use the full dynamic range. The binary mode encodes bit-planes of the image without using the transform. This JBIG-like system uses the resources already available in the CREW system. This paper introduces some basic concepts of CREW and describes the binary mode in detail.
The Direct Solution of the Discrete Poisson Equation on a Rectangle (1970)

where G is a rectangle, Au = 82u/8x2 + 82u/8y2, and v, w are known functions. For computational purposes, this partial differential equation is frequently replaced by a finite difference analogue. These discrete models for (1) consist of linear systems of equations of very large dimension, and it is widely recognized that the usual direct methods (e.g., Gaussian elimination) are unsatisfactory for such systems [18, ?? 21.2-21.3]. Theoretical investigation has, therefore, been primarily directed toward the development of effective iterative methods for the solution of these problems [64], [66]. In recent years, however, direct methods that take advantage of the special block structure of these linear equations have appeared. For the rectangular regions under consideration, these methods can be considerably faster than iterative methods. The purpose of this survey paper is to provide brief summaries and a list of references for methods which can be used to directly solve the finite difference equations. Some of these methods can be applied to problems in more general domains. However, the extensions generally include only simple rectilinear regions, such as L-shaped or T-shaped domains. This is basically due to the fact that the direct methods require a great degree of regularity in the block structure of the matrix equation. In our discussion, we will indicate whether the methods are easily adaptable to more general regions, and to more general elliptic partial differential equations.
The complete nuleotide sequence and structure of the gene encoding bovine phenylethanolamine N‐methyltransferase (1988)

A cDNA clone for bovine adrenal phenylethanolamine N-methyltransferase (PNMT) was used to screen a Charon 28 genomic library. One phage was identified, designated lambda P1, which included the entire PNMT gene. Construction of a restriction map, with subsequent Southern blot analysis, allowed the identification of exon-containing fragments. Dideoxy sequence analysis of these fragments, and several more further upstream, indicates that the bovine PNMT gene is 1,594 base pairs in length, consisting of three exons and two introns. The transcription initiation site was identified by two independent methods and is located approximately 12 base pairs upstream from the ATG translation start site. The 3' untranslated region is 88 base pairs in length and contains the expected polyadenylation signal (AATAAA). A putative promoter sequence (TATA box) is located about 25 base pairs upstream from the transcription initiation site. Computer comparison of the nucleotide sequence data with the consensus sequences of known regulatory elements revealed potential binding sites for glucocorticoid receptors and the Sp1 regulatory protein in the 5' flanking region of the gene. Additionally, comparison of the sequence of the exons of the PNMT gene with cDNA sequences for other enzymes involved in biogenic amine synthesis revealed no significant homology, indicating that PNMT is not a member of a multigene family of catecholamine biosynthetic enzymes.
Control of pesticide residues by liquid chromatography‐mass spectrometry to ensure food safety (2006)

Liquid chromatography-mass spectrometry (LC-MS) has become an invaluable technique for the control of pesticide residues to ensure food safety. After an introduction about the regulations that highlights its importance to meet the official requirements on analytical performance, the different mass spectrometers used in this field of research, as well as the LC-MS interfaces and the difficulties associated with quantitative LC-MS determination, are discussed. The ability to use practical data for quantifying pesticides together with the option of obtaining structural information to identify target and non-target parent compounds and metabolites are discussed. Special attention is paid to the impact of sample preparation and chromatography on the ionization efficiency of pesticides from food. The last section is devoted to applications from a food safety point of view. (c) 2006 Wiley Periodicals, Inc.
Monitoring Single-Molecule Reactivity on a Carbon Nanotube (2007)

Using point-functionalized carbon nanotube devices, we demonstrate continuous, multihour monitoring of a single carboxylate group interacting with its immediate environment. The conductance of the nanotube device directly transduces single-molecule attachments and detachments in the presence of the carboxylate-selective reagent 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). Because only one carboxylate is present in the device, it can be studied through hundreds of reactions, providing the statistical accuracy to directly determine a 12 s lifetime of the carboxy-EDC complex. An additional instability of the complex is transduced in real time and observed to have a median lifetime of 2 ms. By determining a turnover time in good agreement with bulk measurements and simultaneously illuminating additional dynamics, these results demonstrate this platform's potential for complementing optical methods in single-molecule research.
A Simple, Sensitive, and Economic Assay for Choline and Acetylcholine Using HPLC, an Enzyme Reactor, and an Electrochemical Detector (1985)

A simple, efficient, economic, and sensitive method is presented for the detection of choline and acetylcholine in neuronal tissue using HPLC, a postcolumn enzyme reactor with immobilized enzyme, and electrochemical detection. The method is based on a separation of choline and acetylcholine by cation exchange HPLC followed by passage of the effluent through a postcolumn reactor containing a mixture of acetylcholinesterase and choline oxidase; the latter enzyme converts choline to betaine and hydrogen peroxide, the former enzyme hydrolyzes acetylcholine to acetate and choline. The hydrogen peroxide produced is electrochemically detected. A simple and efficient preparation of neuronal tissue is described using an optional prepurification step on Sephadex G-10 columns, offering the possibility to detect choline and acetylcholine as well as catecholamines and their related metabolites in the same tissue sample. The sensitivity of the assay system is 250 fmol for choline and 500 fmol for acetylcholine.
FLT3 inhibition as a targeted therapy for acute myeloid leukemia (2009)

Oral FLT3 inhibitors offer a hope of improved treatment outcomes for patients with relapsed and newly diagnosed AML.
Volatility and Speciation of Mercury during Pyrolysis and Gasification of Five Chinese Coals (2011)

The fate of mercury in coal gasification systems is closely relevant to its transformation in fuel gases and subsequent release into the environment. This paper presents a study of the volatility and speciation of mercury during pyrolysis and gasification of five typical Chinese coals commonly used in gasification stations. Experiments were conducted on a bench-scale fixed bed under atmospheric pressure at final temperatures from 400 to 1200 °C, in 200 °C increments. The mercury concentration in coals ranged from 0.259 to 8.339 μg/g. The gas-phase mercury was analyzed by an atomic fluorescence mercury analyzer according to the Ontario Hydro Method. It was observed that mercury volatility increased monotonically with temperature over 30 min. Hg0(g) was the dominant species at most of the temperatures and holding times examined. It was also observed that high temperatures and long times enhanced mercury oxidation. With the temperature increasing from 800 to 1200 °C, Hg2+(g) increased from 5% to 35% during pyrolysis, and from 20% to 60% during gasification. The ratio of Hg2+/HgT reached its minimum at 800 °C for one coal (GZA) during pyrolysis, whereas for two other coals (BS and SF) the maximum value of that ratio was higher than the other coals and occurred during high temperature steam gasification at 1200 °C, respectively. The maximum value of the ratio of Hg2+/HgT was achieved during the high temperature steam gasification. Comparative studies on mercury emission under different conditions indicated that the volatility and speciation of mercury may correlate with the halogen concentration in the coals. However, no obvious correlation between Hg2+/HgT and basic oxides or acidic oxides in the ash was observed.
Ofatumumab versus Teriflunomide in Multiple Sclerosis (2020)

Among patients with multiple sclerosis, ofatumumab was associated with lower annualized relapse rates than teriflunomide. (Funded by Novartis; ASCLEPIOS I and II ClinicalTrials.gov numbers, NCT02792218 and NCT02792231.).
Physiological effects of sublethal levels of acid water on fish (1976)

Oxygen-consumption rates as milligrams of oxygen per gram of fish per hour (mg 02/g per hr) were measured in a flow-through respirometer for bluegill sunfish, Lepomis macrochirus Rafinesque; pumpkinseed sunfish, Lepomis gibbosus (Linnaeus); and brown bullheads, Ictalurus nebulosus (LeSueur). Non-stress standard oxygen-consumption rates were established using tap water. L. macrochirus exhibited a decrease in mean oxygen-consumption rates in acid water - 0.081 mg 02/g per hr compared to 0.111 in tap water. L. gibbosus exhibited increased oxygen-consumption rates in acid water - 0.106 mg 02/g per hr compared to 0.082 in tap water. I. nebulosus exhibited lower oxygen-consumption rates in acid water than in tap water - 0.075 mg 02/g per hr compared to 0.124. In acid water (pH 4.0-3.0), ventilation rates were highly variable and frequently increased to three times the standard resting rate. As an indication of physiological stress, the changes in oxygen-consumption rate in acid waters compared to standard tap water were significant for each fish species. (GRA)
Echo Algorithms: Depth Parallel Operations on General Graphs (1982)

This paper describes a method for the detection of properties of general graphs in an environment in which each node can be considered an autonomous processor, interacting with its neighbors by passing messages.
Reduced-state sequence detection of multilevel partial-response signals (1992)

This work is concerned with the problem of designing reduced-complexity Viterbi decoders for the transmission of digital data over intersymbol interference channels. First, optimal state-grouping for constructing reduced-state trellises is presented and illustrative examples are given for multilevel transmission over partial-response channels of the type 1+or-D/sup n/, (1+D)/sup 2/, (1+D)/sup 2/(1-D), and (1+D)/sup 3/(1-D). Then, the quaternary 1-D type partial-response channel is considered in more detail and a difference-matric algorithm employing state-reduction is derived and shown to result in a simple decoding scheme.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Understanding and manipulating sucrose phloem loading, unloading, metabolism, and signalling to enhance crop yield and food security (2013)

Sucrose is produced in, and translocated from, photosynthetically active leaves (sources) to support non-photosynthetic tissues (sinks), such as developing seeds, fruits, and tubers. Different plants can utilize distinct mechanisms to transport sucrose into the phloem sieve tubes in source leaves. While phloem loading mechanisms have been extensively studied in dicot plants, there is less information about phloem loading in monocots. Maize and rice are major dietary staples, which have previously been proposed to use different cellular routes to transport sucrose from photosynthetic cells into the translocation stream. The anatomical, physiological, and genetic evidence supporting these conflicting hypotheses is examined. Upon entering sink cells, sucrose often is degraded into hexoses for a wide range of metabolic and storage processes, including biosynthesis of starch, protein, and cellulose, which are all major constituents for food, fibre, and fuel. Sucrose, glucose, fructose, and their derivate, trehalose-6-phosphate, also serve as signalling molecules to regulate gene expression either directly or through cross-talk with other signalling pathways. As such, sugar transport and metabolism play pivotal roles in plant development and realization of crop yield that needs to be increased substantially to meet the projected population demand in the foreseeable future. This review will discuss the current understanding of the control of carbon partitioning from the cellular to whole-plant levels, focusing on (i) the pathways employed for phloem loading in source leaves, particularly in grasses, and the routes used in sink organs for phloem unloading; (ii) the transporter proteins responsible for sugar efflux and influx across plasma membranes; and (iii) the key enzymes regulating sucrose metabolism, signalling, and utilization. Examples of how sugar transport and metabolism can be manipulated to improve crop productivity and stress tolerance are discussed.
Ship Integration - a Prerequisite for New Navy Helicopters (2007)

This paper explores the problem of ship integration in naval helicopters, with a specific focus on the problems inherent in operating helciopters from small ships, especially surface combatants. Specific limitations of the Australian MRH90 are explored, and a range of alternative integration solutions surveyed.
Correlated Low-Frequency BOLD Fluctuations in the Resting Human Brain Are Modulated by Recent Experience in Category-Preferential Visual Regions (2009)

The resting brain is associated with significant intrinsic activity fluctuations, such as the correlated low-frequency (LF) blood oxygen level-dependent (BOLD) fluctuations measured by functional magnetic resonance imaging. Despite a recent expansion of studies investigating resting-state LF-BOLD correlations, their nature and function are poorly understood. A major constraint on LF-BOLD correlations appears to be stable properties of anatomic connectivity. There is also evidence that coupling can be modulated by recent or ongoing task performance, suggesting that certain components of correlated dynamics are malleable on short timescales. Here, we compared activity during extended periods of rest following performance of 2 distinct cognitive tasks using different categories of visual stimuli-faces and complex scenes. Prolonged exposure to these distinct categories of visual information caused frontal networks to couple differentially with posterior category-preferential visual regions during subsequent periods of rest. In addition, we report preliminary evidence suggesting that conditions exist in which the degree of modulation of LF-BOLD correlations predicts subsequent memory. The finding that resting-state LF-BOLD correlations are modulated by recent experience in functionally specific brain regions engaged during prior task performance clarifies their role as a dynamic phenomenon which may be involved in mnemonic processes.
Preparation of High-T<sub>c</sub> Bi-Sr-Ca-Cu-O Films on MgO Substrates by the Liquid Phase Epitaxial (LPE) Method (1989)

Thin films of high- T c superconductor Bi 2 Sr 2 CaCu 2 O x were prepared on MgO(100) substrates by a liquid phase epitaxial method. Several kinds of fluxes were applied for preparation of Bi 2 Sr 2 CaCu 2 O x thin films, and KCl was found to be the best among them. The film consisted of two phases, Bi 2 Sr 2 CaCu 2 O x and Bi 2 Sr 2 CuO x . The onset T c in the superconducting transition was at 95 K in an as-grown state, but zero resistivity was not observed over 50 K.
Winning the SoC revolution : experiences in real design (2003)

In 1998-99, at the dawn of the SoC Revolution, we wrote Surviving the SOC Revolution: A Guide to Platform Based Design. In that book, we focused on presenting guidelines and best practices to aid engineers beginning to design complex System-on-Chip devices (SoCs). Now, in 2003, facing the mid-point of that revolution, we believe that it is time to focus on winning. In this book, Winning the SoC Revolution: Experiences in Real Design, we gather the best practical experiences in how to design SoCs from the most advanced design groups, while setting the issues and techniques in the context of SoC design methodologies. As an edited volume, this book has contributions from the leading design houses who are winning in SoCs - Altera, ARM, IBM, Philips, TI, UC Berkeley, and Xilinx. These chapters present the many facets of SoC design - the platform based approach, how to best utilize IP, Verification, FPGA fabrics as an alternative to ASICs, and next generation process technology issues. We also include observations from Ron Wilson of CMP Media on best practices for SoC design team collaboration. We hope that by utilizing this book, you too, will win the SoC Revolution
Design of micron MOS switching devices (1972)

Modern photolithographic technology offers the capability of fabricating MOSFET devices of micron dimensions and less. It is by no means obvious that such small devices can be designed with suitable electrical characteristics for LSI switchivg applications. In this talk we will describe short-channel devices ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L_{eff} \sim 1</tex> µ) designed by scaling down larger devices with desirable electrical characteristics. Lateral and vertical dimensions, doping level, and operating voltages and currents are scaled in a self-consistent fashion. In this way small devices have been fabricated without the usual deleterious effects associated with short channels. The measured characteristics of these short-channel devices and the larger devices from which they were scaled will be compared.