gebhart/patrepeval huggingface dataset:
Free-Space Metamaterial Superlenses Using Transmission-line Techniques (2009)

Free-space imaging with a resolution beyond that dictated by the classical diffraction limit may be achieved with a `Veselago-Pendry' superlens made from a metamaterial possessing a number of specific properties, including a negative refractive index (NRI). Although a planar NRI transmission-line (NRI-TL) metamaterial based on the periodic lumped loading of a host TL network has successfully verified the phenomenon of superlensing in a 2D microstrip environment, a true Veselago-Pendry superlens capable of interacting with and manipulating fields in free space remained elusive, largely due to the difficulty of meeting its stringent design constraints and also to the problem of realizing a full 3D isotropic, polarization-independent structure. This work presents the first experimental verification of free-space Veselago-Pendry superlensing using a new class of volumetric metamaterials based on 2D NRI-TL layers that, although polarization-specific, may be easily constructed using available lithographic techniques to interact with free-space sources. An equivalent-circuit model is developed to enable accurate design of the metamaterial's dispersion and transmission characteristics, including those associated with Veselago-Pendry superlensing, and is validated using full-wave simulations. First, a volumetric NRI-TL metamaterial employing fully printed loading elements is fabricated to verify the salient properties of a free-space metamaterial-slab lens. This lens demonstrates diffraction-limited focusing at X-band and, thus, affirms theoretical results that suggest that electrically thick and lossy metamaterials are unable to perform superlensing. Thereafter, a volumetric NRI-TL metamaterial based on discrete lumped elements is designed to meet the conditions of the Veselago-Pendry superlens at 2.40GHz, and experimentally demonstrates a resolution ability over three times better than that afforded by the classical diffraction limit. A microwave superlens designed in this fashion can be particularly useful for illumination and discrimination of closely spaced buried objects over practical distances by way of back-scattering, for example, in tumour or landmine detection, or for targeted irradiation over electrically small regions in tomography or hyperthermia applications. Possible optical implementations of the volumetric topology are also suggested, and finally, a fully isotropic, polarization-independent 3D metamaterial structure related to the volumetric NRI-TL structure is proposed.
Active Use of Cards in the EFL Class (1997)

The main objective of the techniques suggested here is to provide EFL teachers with some ideas on how to make a dynamic use of cards in the EFL setting so that their students can practice the English language in interesting and challenging situations. Each activity suggested consists of four phases: Materials, Procedure, Language Items and Follow-up.
Acyclic Nucleotides Related to Clitocine: Synthesis and Anti-HIV Activity (1995)

Abstract The syntheses and antiviral activity of analogues of the anti-HIV agents PMEA, PMEDAP, (R)-PMPA, (R)-PMPDAP are described. In these analogues the adenine moiety is replaced by 4,6-diamino-5-nitro-pyrimidine (the aglycon of clitocine) or 2,4,6-triamino-5-nitro-pyrimidine. The synthesis of similar acyclic phosphonates related to PMEG and (R)-2′-methyl-PMEG is also reported. Some compounds proved to be active as anti-HIV agents.
Broadband seismic data — The importance of low frequencies (2013)

ABSTRACT We considered the importance of low frequencies in seismic reflection data for enhanced resolution, better penetration, and waveform and impedance inversion. We reviewed various theoretical arguments underlining why adding low frequencies may be beneficial and provided experimental evidence for the improvements by several case studies with recently acquired broadband data. We discussed where research and development efforts in the industry with respect to low frequencies should be focusing.
Gated phase-modulation approach to fiber-optic gyroscope with linearized scale factor (1984)

A phase-modulation approach to closed-loop fiber-optic gyroscopes is described that uses an all-fiber gyroscope, which can provide a linearized scale factor. Preliminary experimental results with manual closing of the feedback loop show good linearity in the scale factor. This approach has, in theory, an inherent suppression of source-wave-length dependence of the scale factor.
Measuring relationship strength in online social networks based on users' activities and profile information (2013)

Using online social networks as a means of interchanging information and ideas is developing daily so that internet users spend too much time in social network websites. This fact has turned social networks into very rich sources of information for analyzing users' activities and relationships. In recent years, most research in analysis of social networks has dealt with the friendship network. Since the friendship network is binary, the analysis thereof is of no difference between two users who are very close friends or farther acquaintances. Therefore, the result of the analysis would be not real in many cases. In this paper, we tried to measure relationship strength based on users' activities and profile information. For this purpose, a Facebook application was developed so as to collect users' information. Then based on the users' answers to the questionnaire, we measured their relationship strength at four levels. After outlier removal and normalization of reminder data, some of the features were removed based on the Information Gain criterion. Then considering the collected data, two models of Decision Tree and multilayer perceptron were used so as to measure the users' relationship strength. Having applied 10-fold Cross Validation, the validity of the learned model was evaluated. Based on our experiments, multilayer perceptron could predict the users' relationship strength with 72% accuracy and the accuracy of decision tree with ID3 learning algorithm is a bit lower. Finally In two-class case, we compared MLP with SVM and found that MLP achieved 87% of classification accuracy. Based on accuracy, recall and precision we concluded that MLP can classify relationship strength better.
Syndecan‐1, a key regulator of cell viability in endometrial cancer (2007)

Syndecan-1 is one of the major proteoglycans on cell surfaces involved in major biological processes. Although loss of syndecan-1 correlates well with the gain of cancerous characteristics in a wide range of cancers, increased expression of syndecan-1 also coincides with adverse outcomes in some cancers, including breast, ovarian and pancreatic cancers. For this Janus-faced attitude of syndecan-1, we sought to examine expression patterns of syndecan-1 in endometrial carcinoma (EC) and gain insight into the roles of syndecan-1. Immunohistochemical examinations of 109 endometrial tissue samples from myoma, hyperplasia and EC uteri revealed that syndecan-1 expression was significantly upregulated in EC compared with hyperplasia (p < 0.001). To evaluate pathophysiological functions of syndecan-1, its expression level was altered, and subsequent outcomes were examined using human endometrial cancer cell lines such as HEC-1A, AN3CA and KLE cells. Overexpression of syndecan-1 increased the growth of HEC-1A cells regardless of anchorage dependence while silencing syndecan-1 by antisense RNAs caused apoptotic cell death. Consistent with decreased viability, the loss of syndecan-1 was also accompanied by a decrease in the activation of Erk and Akt and a concomitant decrease in the phosphorylation of PTEN and PDK1, which are known as negative and positive regulators of Akt activation, respectively. These down-regulatory effects were reversed upon overexpression of syndecan-1. Collectively together, the aforementioned findings lend support to the notion that upregulation of syndecan-1 may be a critical element for endometrial cancers in maintaining their viability and thus can serve as a cancer specific therapeutic and diagnostic marker.
Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression (1996)

The region upstream of the multiple antibiotic resistance efflux operon mexA-mexB-oprM in Pseudomonas aeruginosa was sequenced, and a gene, mexR, was identified. The predicted MexR product contains 147 amino acids with a molecular mass of 16,964 Da, which is consistent with the observed size of the overexpressed mexR gene product. MexR was homologous to MarR, the repressor of MarA-dependent multidrug resistance in Escherichia coli, and other repressors of the MarR family. A mexR knockout mutant showed a twofold increase in expression of both plasmid-borne and chromosomal mexA-reporter gene fusions compared with the MexR+ parent strain, indicating that the mexR gene product negatively regulates expression of the mexA-mexB-oprM operon. Furthermore, the cloned mexR gene product reduced expression of a plasmid-borne mexA-lacZ fusion in E. coli, indicating that MexR represses mexA-mexB-oprM expression directly. Consistent with the increased expression of the efflux operon in the mexR mutant, the mutant showed an increase (relative to its MexR+ parent) in resistance to several antimicrobial agents. Expression of a mexR-lacZ fusion increased threefold in a mexR knockout mutant, indicating that mexR is negatively autoregulated. OCR1, a nalB multidrug-resistant mutant which overproduces OprM, exhibited a greater than sevenfold increase in expression of a chromosomal mexA-phoA fusion compared with its parent. Introduction of a mexR knockout mutation in strain OCR1 eliminated this increase in efflux gene expression and, as expected, increased the susceptibility of the strain to a variety of antibiotics. The nucleotide sequences of the mexR genes of OCR1 and its parental strain revealed a single base substitution in the former which would cause a predicted substitution of Trp for Arg at position 69 of its mexR product. These data suggest that MexR possesses both repressor and activator function in vivo, the activator form being favored in nalB multidrug-resistant strains.
The cyclisation of benzylaminonitriles. Part 7. Regiospecific formation of methoxy-substituted isoquinolin-4-ones using methylthio activating groups (1990)

Cyclisation of 3,4-dialkoxybenzylaminoacetonitriles proceeds preferentially through a spiro intermediate. A 2,3-dialkoxy analogue will therefore normally give a 5,6-dialkoxyisoquinolinone after rearrangement and 7,8-dimethoxy substitution is not obtained. It is shown that a suitably placed methylthio group, which can be removed after cyclisation, can change the mode of cyclisation from rearrangement via a spiro intermediate to simple ortho-attack, giving the desired 7,8-dialkoxy substitution pattern. In principle, this approach to regiocontrol could be of value in many reactions involving electrophilic attack on a benzene ring.
Processing carbon nanotubes with holographic optical tweezers (2004)

We report the first demonstration that carbon nanotubes can be trapped and manipulated by optical tweezers. This observation is surprising because individual nanotubes are substantially smaller than the wavelength of light, and thus should not be amenable to optical trapping. Even so, nanotube bundles, and perhaps even individual nanotubes, can be transported at high speeds, deposited onto substrates, untangled, and selectively ablated, all with visible light. The use of holographic optical tweezers, capable of creating hundreds of independent traps simultaneously, suggests opportunities for highly parallel nanotube processing with light.
A prática do (a) enfermeiro (a) na inserção do cateter de Folley em pacientes de unidade de terapia intensiva: limites e possibilidades (2013)

Backgound and Objectives: Nursing has an important role in urinary tract infection prevention and control. Urinary catheters insertion represents the local topography with the highest rate of hospital infection. Foley catheter placement is performed solely by the nurse and requires aseptic techniques during its performance, thus preventing risks to the patients. The study aimed to evaluate the training of nurses on Foley catheter insertion and point out limits and possibilities of this practice in patients at the Intensive Care Unit (ICU) of Hospital Geral do Interior da Bahia (HGIB). Methods: This was a qualitative, exploratory and descriptive study. Data collection was carried out through semi-structured interviews. After data analysis, two categories were evaluated, namely: the training of nurses on Foley catheter insertion in ICU patients and the limits and possibilities of Foley catheter insertion practice by nurses in ICU patients. Bardin analysis was used for data analysis. Results: The study shows that the nurse’s practice on Foley catheter insertion in ICU patients is based on the use of aseptic techniques for urinary tract infection prevention, theoretical and practical knowledge on Foley catheter insertion in ICU patients, knowledge on urinary tract infections and associations with catheter insertion, whereas the limits and possibilities of Foley catheter insertion practice by nurses are understood through measures to minimize the risk of hospital infection caused by long-term catheter use in the ICU. Nurses point out that the risks of hospital infection are inherent to long-term catheter use. This is an important fact, as the knowledge or its absence may constitute a limit or possibility for Foley catheter insertion practice by the nurse in ICU patients. Conclusion: Nurses must seek the systematization of knowledge, which warrants support for the team, as well as information, safety and prompt care, allowing the reduction of urinary tract infection rates and its complications in critically-ill patients. Training of the multidisciplinary team is necessary, as well as continuing education, interaction and communication with the medical team and the Hospital Infection Control Committee (CCIH) to prevent and fi ght against hospital infections. KEYWORDS: Nursing. Hospital Infection Control. Intensive Care Unit. Catheter Folley.
A motion correction scheme by twin‐echo navigation for diffusion‐weighted magnetic resonance imaging with multiple RF echo acquisition (1998)

In this paper, a series of diffusion-weighted fast spin-echo (FSE) sequences with a new motion correction scheme are introduced. This correction scheme is based on the navigator echo technique. Unlike conventional spin-echo imaging, motion correction for FSE is complicated by the phase oscillation between odd-numbered and even-numbered echoes and the complex phase relationship between spin echo and stimulated echo components. In our approach, incoherent phase shifting due to motion is monitored by consecutive acquisition of two navigator echoes, which provide information on both inter-echo and intra-echo train phase shifts. Applications to both phantom and in vivo studies are presented.
The Quebec Back Pain Disability Scale (1995)

The Quebec scale can be recommended as an outcome measure in clinical trials, and for monitoring the progress of individual patients participating in treatment or rehabilitation programs.
Reliable anticoagulation with enoxaparin in patients undergoing percutaneous coronary intervention: The pharmacokinetics of enoxaparin in PCI (PEPCI) study (2004)

The objective of this study was to evaluate the pharmacokinetic response to intravenous (IV) enoxaparin given 8-12 hr after subcutaneous (SC) dosing in patients undergoing percutaneous coronary intervention (PCI). Fifty-five patients received SC enoxaparin (1 mg/kg every 12 hr) followed by an IV bolus (0.3 mg/kg) 8-12 hr after the last SC dose, at the start of PCI or during catheterization. Anti-Xa levels were within the target range in 98% of patients 2-8 hr after the last SC dose, in 96% of patients following the IV bolus, and in 91% of patients for a further 2 hr. Subcutaneous enoxaparin (1 mg/kg every 12 hr) provides sufficient anti-Xa levels for PCI 2-8 hr after the last dose. An additional 0.3 mg/kg enoxaparin dose given IV 8-12 hr after the last SC dose reliably maintains anti-Xa levels within the target for at least 2 additional hr.
Thyroid Hormone Stimulates Protein Synthesis in the Cardiomyocyte by Activating the Akt-mTOR and p70S6K Pathways (2006)

Thyroid hormones affect cardiac growth and phenotype; however, the mechanisms by which the hormones induce cardiomyocyte hypertrophy remain uncharacterized. Tri-iodo-L-thyronine (T3) treatment of cultured cardiomyocytes for 24 h resulted in a 41 +/- 5% (p < 0.001) increase in [(3)H]leucine incorporation into total cellular protein. This response was abrogated by the phosphatidylinositol 3-kinase (PI3K) inhibitor, wortmannin. Co-immunoprecipitation studies showed a direct interaction of cytosol-localized thyroid hormone receptor TRalpha1 and the p85alpha subunit of PI3K. T3 treatment rapidly increased PI3K activity by 52 +/- 3% (p < 0.005), which resulted in increased phosphorylation of downstream kinases Akt and mammalian target of rapamycin (mTOR). This effect was abrogated by pretreatment with wortmannin or LY294002. Phosphorylation of p70(S6K), a known target of mTOR, occurred rapidly following T3 treatment and was inhibited by rapamycin and wortmannin. In contrast, phosphorylation of the p85 variant of S6K in response to T3 was not blocked by LY294002, wortmannin, or rapamycin, thus supporting a T3-activated pathway independent of PI3K and mTOR. 40 S ribosomal protein S6, a target of p70(S6K), and 4E-BP1, a target of mTOR, were both phosphorylated within 15-25 min of T3 treatment and could be inhibited by wortmannin and rapamycin. Thus, rapid T3-mediated activation of PI3K by cytosolic TRalpha1 and subsequent activation of the Akt-mTOR-S6K signaling pathway may underlie one of the mechanisms by which thyroid hormone regulates physiological cardiac growth.
Gateway discovery and routing in ad hoc networks with NAT-based internet connectivity (2005)

The paper presents gateway discovery and routing schemes for ad hoc networks with NAT-based Internet connectivity. To maintain a reachable gateway set (RGS) and up-to-date routes to gateways, an extended HELLO (e-HELLO) message is used. A mobile node includes its RGS in the e-HELLO message and periodically broadcasts it to neighbors. On receiving the e-HELLO message, a mobile node updates its RGS and routes to gateways. To prevent on-going sessions from being broken, the current default gateway is maintained as long as it is in the RGS and there exists any on-going session. A proxy route reply (p-RREP) message is used to allow a source node to change its default gateway during route discovery. Also, a packet routing scheme for subnet-based ad hoc networks with Internet connectivity is presented. The proposed gateway discovery and routing schemes can efficiently support NAT-based Internet connectivity in ad hoc networks.
A Trusted Smart Phone and its Applications in Electronic Payment (2010)

With the growing intelligence and popularity of mobile phones, and the trend of cellular network's convergence to IP based network, more and more mobile applications emerge on the market. For mission critical applications, like the electronic payment which will be discussed in this paper, the lack of trust in the underlying mobile infrastructure and secure interface to legacy systems (for this case, the banking systems) poses obstacles to their widespread presence in mobile services. Recently, the exposure of hacking of iPhone and other smart phones further emphasizes the criticality of establishing a trust platform for mobile applications. This paper analyzes the building blocks of the trusted smart phone, and proposes a framework to provide a trusted platform for mobile electronic payment. Such a proposed system may allow direct interface to the banking systems due to the banking industry recognized strong security, and hence, may enable its widespread use.
Heart Rate Dynamics and Vulnerability to Ventricular Tachyarrhythmias (1997)

Sudden arrhythmic death is the most common mode of death in Western countries. An increased understanding of the pathophysiology and trigger mechanisms of life-threatening ventricular tachyarrhythmias in patients with structural heart disease can provide a logical basis for improved therapeutic strategies in the prevention of sudden death. Analysis of heart rate variability (HRV) from ambulatory electrocadiographic recordings can identify the patients at increased risk for arrhythmic death after an acute myocardial infarction. Despite the epidemiological evidence of an association between low HRV and sudden arrhythmic death, the pathophysiological link of this association has not been completely understood. An important approach to understand this association is to investigate the heart rate dynamics before the spontaneous onset of life-threatening arrhythmias. Analysis of heart rate behaviour preceding the spontaneous onset of ventricular tachyarrhythmias has shown that overall HRV is impaired in patients who develop spontaneous ventricular tachycardia during the Holter recording. Recently, quantitative analysis of Poincaré plots of successive R-R intervals has shown that reduced long-term R-R interval variability, associated with episodes of beat-to-beat sinus alternans, is a specific sign of a propensity for spontaneous onset of ventricular tachycardia. These studies suggest that abnormal heart rate behaviour reflects an electrical instability favoring the onset of life-threatening arrhythmia and provide evidence that altered neurohumoral or autonomic regulation is an important trigger mechanism for the spontaneous onset of life-threatening arrhythmia. Future research in larger patient populations will reveal whether analysis of dynamic behaviour of cardiac electrical signals will give new insights into the mechanisms of life-threatening arrhythmias and help in the development of new therapeutic options for the prevention of sudden arrhythmic death.
First‐trimester aneuploidy screening using serum human chorionic gonadotropin (hCG), free ahCG, and progesterone (1991)

Immunochemical serum assays for human chorionic gonadotropin (hCG), the free ahCG subunit, and progesterone (P) were considered separately and in combination for their ability to screen for chromosomally abnormal pregnancies in the first trimester. Maternal serum was collected from 141 women undergoing chorionic villus sampling at 9-12 menstrual weeks. Trisomy 21 pregnancies had significantly higher hCG levels, while trisomy 18 and 13 pregnancies had markedly lower hCG and progesterone levels than those of chromosomally normal pregnancies. However, the discrimination of normal from aneuploid pregnancies was poor with either hCG alone, progesterone alone, or free ahCG alone. Much improved discrimination was obtained by combining hCG, free ahCG, and P into an aneuploidy index [(P/hCG)(free ahCG/hCG)]. This index distinguished 9 out of 17 (53 per cent) of the trisomy 21 pregnancies, while only misidentifying 5 out of 112 (4.5 per cent) of the normal pregnancies. The aneuploidy index thus appears promising as a first-trimester biochemical screen for aneuploid pregnancies.