gebhart/patrepeval huggingface dataset:
Pressure sensor based on the fiber-optic extrinsic Fabry-Perot interferometer (2010)

Pressure sensors based on fiber-optic extrinsic Fabry-Perot interferometer (EFPI) have been extensively applied in various industrial and biomedical fields. In this paper, some key improvements of EFPI-based pressure sensors such as the controlled thermal bonding technique, diaphragm-based EFPI sensors, and white light interference technology have been reviewed. Recent progress on signal demodulation method and applications of EFPI-based pressure sensors has been introduced. Signal demodulation algorithms based on the cross correlation and mean square error (MSE) estimation have been proposed for retrieving the cavity length of EFPI. Absolute measurement with a resolution of 0.08 nm over large dynamic range has been carried out. For downhole monitoring, an EFPI and a fiber Bragg grating (FBG) cascade multiplexing fiber-optic sensor system has been developed, which can operate in temperature 300 °C with a good long-term stability and extremely low temperature cross-sensitivity. Diaphragm-based EFPI pressure sensors have been successfully used for low pressure and acoustic wave detection. Experimental results show that a sensitivity of 31 mV/Pa in the frequency range of 100 Hz to 12.7 kHz for aeroacoustic wave detection has been obtained.
Interpreting children’s mental health problems (2010)

How professionals conceptualise the common problems of children and young people affects the treatment they provide, as Michael Buxton explains
Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growth (2009)

The anti-proliferation effect of oxaliplatin in HCC cells is due to induction of apoptosis. Therefore, oxaliplatin may be an effective treatment for HCC and its use merits further in-depth investigation.
Ocular Pathogen or Commensal: A PCR-Based Study of Surface Bacterial Flora in Normal and Dry Eyes (2007)

Molecular analysis revealed a diverse ocular surface bacterial population. In addition to the normal flora, various potentially pathogenic bacteria were identified. The detection of known pathogens in both normal and dry eyes, with minimal signs of infection, presents a diagnostic dilemma. It remains unknown whether their presence is associated with inflammation and reduced goblet cell density or whether they adversely affect the ocular surface predisposing it to abnormal microbial colonization. In the absence of overt clinical infection, it is unknown whether such results should prompt intervention with therapy.
Density-dependent regulation of growth of BSC-1 cells in cell culture: control of growth by serum factors. (1977)

BSC-1 cells grow slowly, to high cell density, in medium with 0.1% calf serum. An increase in the serum concentration increases both the growth rate of the cells and the final cell density. The serum can be replaced to some extent by epidermal growth factor (EGF). Initiation of DNA synthesis in BSC-1 cells that have spread into a "wound" in a crowded cell layer requires the addition of a trace of serum or EGF, if the cells have previously been deprived of serum. The binding of 125I-labeled EGF to low-density and high-density BSC-1 cells has been studied. Binding is faster to low-density cells. Cells at low cell density also bind much more EGF per cell than cells at high cell density. The fraction of bound 125I-labeled EGF that is present on the cell surface as intact EGF is larger at low than at high cell density. The results indicate that the number of available EGF receptors per cell decreases drastically as the cell density increases. It is suggested that a decrease in the number of available EGF receptor sites per cell, and the accompanying decrease in sensitivity of the cells to EGF, contributes to density-dependent regulation of growth of these cells.
Antibiotic Susceptibilities of <i>Pseudomonas aeruginosa</i> Isolates Derived from Patients with Cystic Fibrosis under Aerobic, Anaerobic, and Biofilm Conditions (2005)

Recent studies have determined that Pseudomonas aeruginosa can live in a biofilm mode within hypoxic mucus in the airways of patients with cystic fibrosis (CF). P. aeruginosa grown under anaerobic and biofilm conditions may better approximate in vivo growth conditions in the CF airways, and combination antibiotic susceptibility testing of anaerobically and biofilm-grown isolates may be more relevant than traditional susceptibility testing under planktonic aerobic conditions. We tested 16 multidrug-resistant isolates of P. aeruginosa derived from CF patients using multiple combination bactericidal testing to compare the efficacies of double and triple antibiotic combinations against the isolates grown under traditional aerobic planktonic conditions, in planktonic anaerobic conditions, and in biofilm mode. Both anaerobically grown and biofilm-grown bacteria were significantly less susceptible (P < 0.01) to single and combination antibiotics than corresponding aerobic planktonically grown isolates. Furthermore, the antibiotic combinations that were bactericidal under anaerobic conditions were often different from those that were bactericidal against the same organisms grown as biofilms. The most effective combinations under all conditions were colistin (tested at concentrations suitable for nebulization) either alone or in combination with tobramycin (10 microg ml(-1)), followed by meropenem combined with tobramycin or ciprofloxacin. The findings of this study illustrate that antibiotic sensitivities are dependent on culture conditions and highlight the complexities of choosing appropriate combination therapy for multidrug-resistant P. aeruginosa in the CF lung.
The World that Changes the World (2012)

If there is an X PRIZE for collaborative thought leadership of the social ecosystem, this book would get it. Dr. Peter H. Diamandis. Chairman and CEO, X PRIZE Foundation. The World that Changes the World is thought leadership at its best-envisioning the future through reflection and analysis of past trends and contemporary challenges. Senator the Hon. Ursula Stephens. Australian Parliamentary Secretary for Social Inclusion and the Voluntary Sector. The multifaceted, multinational, multisectoral insights in this volume offer inspiration, ideas, and opportunity for action and impact. Dr. Melissa
Lightweight concurrency primitives for GHC (2007)

The Glasgow Haskell Compiler (GHC) has quite sophisticated support for concurrency in its runtime system, which is written in low-level C code. As GHC evolves, the runtime system becomes increasingly complex, error-prone, difficult to maintain and difficult to add new concurrency features.
P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site (1995)

P-glycoprotein (Pgp or multidrug-resistance protein) shows drug-stimulated ATPase activity. The catalytic sites are known to be of low affinity and specificity for nucleotides. From the sequence, two nucleotide sites are predicted per Pgp molecule. Using plasma membranes from a multidrug-resistant Chinese hamster ovary cell line, which are highly enriched in Pgp, we show that vanadate-induced trapping of nucleotide at a single catalytic site produces stably inhibited Pgp, with t 1/2 for reactivation of ATPase activity of 84 min at 37 degrees C and >30 h at 4 degrees C. Reactivation of ATPase correlated with release of trapped nucleotide. Concentrations of MgATP and MgADP required to produce 50% inhibition were 9 and 15 microM, respectively, thus the apparent affinity for nucleotide is greatly increased by vanadate-trapping. The trapped nucleotide species was ADP. Divalent Cation was required, with magnesium, manganese, and cobalt all effective: cobalt yielded a very stable inhibited species, t1/2 at 37 degrees C = 18 h. No photocleavage of Pgp was observed after vanadate trapping with MgATP, nor was UV-induced photolabeling of Pgp by trapped adenine nucleotide observed. Vanadate-trapping with 8-azido-ATP followed by UV irradiation caused permanent inactivation and specific labeling of Pgp. Vanadate-induced inhibition was also shown with pure, reconstituted Pgp, with similar characteristics to those in plasma membranes. Vanadate trapping overcomes technical difficulties posed by lack of high affinity nucleotide-binding site(s) or a covalent enzyme-phosphate catalytic intermediate in Pgp. The finding that vanadate trapping of nucleotide at just one site/Pgp is sufficient to give full inhibition at ATPase activity shows that the two predicted nucleotide sites can not function independently as catalytic sites.
Catalytic cracking with an interlayered clay. A two-dimensional molecular sieve (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic cracking with an interlayered clay. A two-dimensional molecular sieveMario L. OccelliCite this: Ind. Eng. Chem. Prod. Res. Dev. 1983, 22, 4, 553–559Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/i300012a008https://doi.org/10.1021/i300012a008research-articleACS PublicationsRequest reuse permissionsArticle Views206Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
THE JOURNAL OF BIOLOGICAL CHEMISTRY: Volume XXXVII, 1919, Pages 223-229 (2009)

Journal Article The Journal of Biological Chemistry: Volume Xxxvii, 1919, Pages 223–229 Get access Thomas B. Osborne, Thomas B. Osborne Laboratory of the Connecticut Agricultural Experiment Station and the Sheffield Laboratory of Physiological Chemistry in Yale University, New Haven Search for other works by this author on: Oxford Academic PubMed Google Scholar Lafayette B. Mendel, Lafayette B. Mendel Laboratory of the Connecticut Agricultural Experiment Station and the Sheffield Laboratory of Physiological Chemistry in Yale University, New Haven Search for other works by this author on: Oxford Academic PubMed Google Scholar Edna L. Ferry Edna L. Ferry Laboratory of the Connecticut Agricultural Experiment Station and the Sheffield Laboratory of Physiological Chemistry in Yale University, New Haven Search for other works by this author on: Oxford Academic PubMed Google Scholar Nutrition Reviews, Volume 35, Issue 8, August 1977, Pages 207–209, https://doi.org/10.1111/j.1753-4887.1977.tb06601.x Published: 01 August 1977 Article history Received: 07 December 1918 Published: 01 August 1977
Robust Track-Following Controller Design in Hard Disk Drives Based on Parameter Dependent Lyapunov Functions (2009)

This paper presents a novel technique for designing robust track-following output-feedback controllers in hard disk drives (HDDs). In this paper, the manufacturing variations of HDDs are modeled as polytopic parametric uncertainties in linear time-invariant discrete-time systems. For this model, the robust track-following control problem is formulated as the worst-case H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> performance optimization. The optimization problem reduces to the one with bilinear matrix inequalities (BMIs), using the parameter dependent Lyapunov functions and the extended LMI condition introduced by de Oliveira. Although the formulated problem is nonconvex, and thus it is difficult to ensure global optimality, a numerical technique called ¿G- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> iteration¿ is applied for optimization to guarantee monotonic non-increase of the worst-case performance during iterations. The proposed design technique will be useful in improving the track-following performance, and thus increasing the storage capacity of HDDs.
Fractional Plans and Orthogonal Arrays (1999)

The prelims comprise: Introduction Kronecker Notation Fractional Factorial Plans Concept of Resolution Optimality Criteria Role of Orthogonal Arrays
Efficient global matrix approach to the computation of synthetic seismograms (1986)

A numerically efficient global matrix approach to the solution of the wave equation in horizontally stratified environments is presented. The field in each layer is expressed as a superposition of the field produced by the sources within the layer and an unknown field satisfying the homogeneous wave equations, both expressed as integral representations in the horizontal wavenumber. The boundary conditions to be satisfied at each interface then yield a linear system of equations in the unknown wavefield amplitudes, to be satisfied at each horizontal wavenumber. As an alternative to the traditional propagator matrix approaches, the solution technique presented here yields both improved efficiency and versatility. Its global nature makes it well suited to problems involving many receivers in range as well as depth and to calculations of both stresses and particle velocities. The global solution technique is developed in close analogy to the finite element method, thereby reducing the number of arithmetic operations to a minimum and making the resulting computer code very efficient in terms of computation time. These features are illustrated by a number of numerical examples from both crustal and exploration seismology.
The Most Precious Things Are Not Jade and Pearls... (2002)

The publication of the draft genome sequences of two subspecies of rice ( indica and japonica ) is a boon for plant biologists. In their Perspective, [Ronald and Leung][1] discuss the impact of the rice genome on our understanding of cereal crop biology and its importance for improving yields of one of the world's most important foods.

 [1]: http://www.sciencemag.org/cgi/content/full/296/5565/58
Thallium in organic synthesis. XXV. Electrophilic aromatic bromination using bromine and thallium(III) acetate (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThallium in organic synthesis. XXV. Electrophilic aromatic bromination using bromine and thallium(III) acetateAlexander McKillop, David Bromley, and Edward C. TaylorCite this: J. Org. Chem. 1972, 37, 1, 88–92Publication Date (Print):January 1, 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://pubs.acs.org/doi/10.1021/jo00966a024https://doi.org/10.1021/jo00966a024research-articleACS PublicationsRequest reuse permissionsArticle Views778Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Acupuncture/acupressure to treat gagging dental patients: a clinical study of anti-gagging effects. (2001)

Noninvasive methods advocated by some clinicians are not very successful in dealing with patient gagging, while sedation approaches run the risk of the patient aspirating foreign bodies. The P-6 Neikuan acupuncture point, located on the wrist, has been used in the Far East for thousands of years for its anti-nausea and anti-anxiety properties. In the West, it is the acupuncture point most studied. Only recently has interest been shown in the P-6 point for its possible anti-gagging effect. The anti-gagging effect of P-6 stimulation is documented in this article. The P-6 point has remarkable anti-gagging effects if stimulation is applied correctly. Clinicians may apply thumb pressure at the P-6 point to achieve some effect, although this is not as effective as acupuncture. Nevertheless, a substantial percentage of gagging patients would be able to go through dental procedures without gagging when the P-6 point is stimulated.
<title>Framework for component-based CNC machines</title> (1998)

Open architecture technology is ushering in new advances in the world of computer numerically controlled machines. Yet, some major benefits of open architecture technology have failed to materialized due to the lack of a standard open architecture specification. We propose an open architecture framework to fill the specification void. The proposed framework supports component-based technology by specifying a control class hierarchy, plug-and-play components and a design framework. This framework can be used to build applications ranging from a single-axis device to a multi- arm robot. An example application applying the framework is documented.
The Ability of a Variety of Polymerases to Synthesize Past Site-specific cis-syn, trans-syn-II, (6–4), and Dewar Photoproducts of Thymidylyl-(3′→5′)-thymidine (1998)

The role of photoproduct structure, 3' --> 5' exonuclease activity, and processivity on polynucleotide synthesis past photoproducts of thymidylyl-(3' --> 5')-thymidine was investigated. Both Moloney murine leukemia virus reverse transcriptase and 3' --> 5' exonuclease-deficient (exo-) Vent polymerase were blocked by all photoproducts, whereas Taq polymerase could slowly bypass the cis-syn dimer. T7 RNA polymerase was able to bypass all the photoproducts in the order cis-syn > Dewar > (6-4) > trans-syn-II. Klenow fragment could not bypass any of the photoproducts, but an exo- mutant could bypass the cis-syn dimer to a greater extent than the others. Likewise T7 DNA polymerase, composed of the T7 gene 5 protein and Escherichia coli thioredoxin, was blocked by all the photoproducts, but the exo- mutant Sequenase 2.0 was able to bypass them all in the order cis-syn > Dewar > trans-syn-II > (6-4). No bypass occurred with an exo- gene 5 protein in the absence of the thioredoxin processivity factor. Bypass of the cis-syn and trans-syn-II products by Sequenase 2.0 was essentially non-mutagenic, whereas about 20% dTMP was inserted opposite the 5'-T of the Dewar photoproduct. A mechanism involving a transient abasic site is proposed to account for the preferential incorporation of dAMP opposite the 3'-T of the photoproducts.
DIFFERENTIATION OF B_(16) MELANOMA CELLSINDUCED BY GINSENOSIDE RH_2 (1996)

The effect of ginsenoside Rh2, a constituent isolated from Panax ginseng C. A. Meyer, on the growth of tumor cells in vitro was investigated. The results showed that Rh2 inhibited the growth of B16 cells at the concentration of 10 micrograms.ml-1 (IC50: 4.1 micrograms.ml-1). Rh2 was found to significantly induce the activity of differentiation of B16 cells at the concentration of 10 micrograms.ml-1 in vitro. The melanin synthesis of Rh2 in treated B16 cells was increased. Morphologically, the Rh2 induced B16 cells turned to be epithelioid cells. B16 cells became dendrite shaped morphologically at higher concentration of Rh2. Flow cytometry demonstrated that the B16 cells treated with Rh2 were blocked at G1 phase.
Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase. (2000)

Glucose transport in skeletal muscle is stimulated by two distinct stimuli, insulin and exercise. The mechanism by which exercise stimulates glucose transport is not known, although it is distinct from the insulin-mediated pathway. Recently, it has been shown that AMP-activated protein kinase (AMPK) is activated by exercise in skeletal muscle, whereas pharmacological activation of AMPK by 5-amino-4-imidazolecarboxamide riboside (AICAR) leads to increased glucose transport. It has been postulated, therefore, that AMPK may be the link between exercise and glucose transport. To address this, we have examined the signaling pathway involved in the stimulation of glucose uptake after activation of AMPK. Here we show that activation of AMPK by AICAR in rat muscle and mouse H-2Kb muscle cells activates glucose transport approximately twofold. AMPK in H-2Kb cells is also activated by hyperosmotic stress and the mitochondrial uncoupling agent, dinitrophenol, both of which lead to increased glucose transport. In contrast, insulin, which activates glucose transport two- to-threefold in both rat muscle and H-2Kb cells, has no effect on AMPK activity. A previous study has shown that AMPK phosphorylates and activates endothelial nitric oxide synthase (NOS). We show here that NOS activity in H-2Kb cells is activated after stimulation of AMPK by AICAR. Treatment of H-2Kb cells or rat muscle with NOS inhibitors completely blocks the increase in glucose transport after activation of AMPK. In addition, an inhibitor of guanylate cyclase also blocks activation of glucose transport by AICAR in H-2Kb cells. These results indicate that activation of AMPK in muscle cells stimulates glucose transport by activation of NOS coupled to downstream signaling components, including cyclic GMP.
On Measuring Supplier Performance Under Vendor-Managed-Inventory Programs in Capacitated Supply Chains (2004)

As widely accepted performance measures in supply chain management practice, frequency-based service levels such as fill rate and stockout rate are often considered in supply contracts under vendor-managed-inventory (VMI) programs. Using a decentralized two-party capacitated supply chain model consisting of one manufacturer and one supplier in a VMI environment, we demonstrate that supplier's service level is in general insufficient for the manufacturer to warrant the desired service level at the customer end. The method by which the supplier achieves her service level to the manufacturer also affects customer service level. By developing bounds on the customer service level, we show that the expected backorders at the supplier should also be taken into account. We suggest a supply contract that offers a menu of different combinations of supplier's service level and expected backorders according to a linear function. Under this contract, the manufacturer can control the end customer service regardless of how the supplier manages her inventory. The supplier has complete flexibility on which combination of the two quantities on the menu to choose according to her own cost functions. Because it does not require any detailed information on supplier's operational characteristics nor her costs, this kind of contract is expected to be easily implementable. In addition, we derive an estimate of the customer service level in terms of the new measures. Our findings have direct implications to supply chain metrics in general: The local service levels are insufficient measures to guarantee the system wide performance. Alternative local measures and/or coordination mechanisms should be employed to achieve desired system performance. Our analysis illustrates a possible way to explore such alternative measures.