gebhart/patrepeval huggingface dataset:
Plant Nucleotide Binding Site–Leucine-Rich Repeat (NBS-LRR) Genes: Active Guardians in Host Defense Responses (2013)

The most represented group of resistance genes are those of the nucleotide binding site-leucine-rich repeat (NBS-LRR) class. These genes are very numerous in the plant genome, and they often occur in clusters at speciﬁc loci following gene duplication and ampliﬁcation events. To date, hundreds of resistance genes and relatively few quantitative trait loci for plant resistance to pathogens have been mapped in different species, with some also cloned. When these NBS-LRR genes have been physically or genetically mapped, many cases have shown co-localization between resistance loci and NBS-LRR genes. This has allowed the identification of candidate genes for resistance, and the development of molecular markers linked to R genes. This review is focused on recent genomics studies that have described the abundance, distribution and evolution of NBS-LRR genes in plant genomes. Furthermore, in terms of their expression, NBS-LRR genes are under fine regulation by cis- and trans-acting elements. Recent findings have provided insights into the roles of alternative splicing, the ubiquitin/ proteasome system, and miRNAs and secondary siRNAs in the regulation of NBS-LRR gene expression at the post-transcriptional, post-translational and epigenetic levels. The possibility to use this knowledge for genetic improvement of plant resistance to pathogens is discussed.
Methotrexate-induced acute lung injury in a patient with rheumatoid arthritis. (2005)

Methotrexate (MTX)-induced acute lung injury developed in a female patient with rheumatoid arthritis. She was successfully treated with high-dose glucocorticoid therapy. During her hospital stay, the serum concentration of surfactant protein (SP)-D, which was markedly elevated on admission, was finally normalized and the disease resolved. However, the serum concentration of Klebs von den Lungen (KL)-6 remained high. Although the mechanisms of lung injury by MTX have not been well defined, serial measurements of serum SPD might be useful for the clinical evaluation of drug-induced acute lung injury.
Pseudophakic adult with progressive optic disc tilt and axial length elongation (2020)

Although progressive optic disc tilt in conjunction with increasing axial myopia in pediatric populations has been documented, it has not been reported in adults but may occur. Scleral stretching due to axial length elongation associated with loss of accommodation after cataract surgery and worsening peripapillary atrophy are possible causes of this finding.
Synergistic enhancement of the antiproliferative activity of<i>cis</i>‐diamminedichloroplatinum(II) by the ether lipid analogue BM41440, an inhibitor of protein kinase C (1989)

The new phospholipid analogue 3-hexadecylmercapto-2-methoxy-methyl-propyl-1-phosphocholine inhibits the phospholipid-calcium-dependent protein kinase, partially purified from Walker carcinoma cells with a Ki value of 0.56 microM. The compound inhibits the phorbol ester stimulated phosphorylation of the ribosomal protein S6 indicating that the depression of Ca2+-phospholipid-dependent protein kinase by the alkyl phospholipid also occurs in intact cells. The dose effect curve for the inhibition of cell proliferation by 3-hexadecylmercapto-2-methoxy-methyl-propyl-1-phosphocholine in Walker cells exhibits a close correlation to the dose effect curve for the depression of Ca2+-phospholipid-dependent protein kinase activity. Although alternative mechanisms cannot be excluded, the data suggest that the growth inhibitory activity of 3-hexadecylmercapto-2-methoxy-methyl-propyl-1-phosphocholine correlates with the inhibition of Ca2+-phospholipid-dependent protein kinase. The antiproliferative activity of 3-hexadecylmercapto-2-methoxy-methyl-propyl-1-phosphocholine is synergistically enhanced by cis-diamminedichloroplatinum(II).
Fast subspace tracking using coarse grain and fine grain parallelism (2002)

Subspace tracking is an integral part of many high resolution adaptive array methods. Unfortunately, the high computational complexity and non-parallel nature of traditional subspace tracking algorithms have deterred their use in real-time systems. We discuss parallel mappings of the fast subspace tracking algorithm. The serial complexity of this algorithm is already among the lowest {O(Nr) for N channels and an r dimensional subspace}. We show that even greater reductions in effective complexity can be achieved by mapping our algorithm onto multiple processors. Near linear speedup is obtained on machines spanning the range from fine grain systolic arrays to coarse grain commercially available MPPs.
Methylation and Gene Expression Responses to Ethanol Feeding and Betaine Supplementation in the Cystathionine Beta Synthase-Deficient Mouse (2014)

The present study has demonstrated relationships among EtOH induction of ASH with aberrant methionine metabolism that was associated with gene body DNA hypomethylation in all autosomes and was prevented by betaine supplementation. The data imply that EtOH-induced changes in selected gene transcript levels and hypomethylation in gene bodies during the induction of ASH are a result of altered methionine metabolism that can be reversed through dietary supplementation of methyl donors.
Amplitude effects associated with shear‐wave splitting (2009)

Shear‐wave anisotropy results in a time delay between two different shear‐wave polarizations S1 and S2. If there are associated differences in attenuation of the amplitudes, then simple time shifting is insufficient to match the S1 and S2 images. This “differential” attenuation leads to both an additional time delay and a frequency dependent amplitude effect. Using a dataset acquired over a heavy oil reservoir, we demonstrate that an improvement to the agreement between P‐S1 and P‐S2 images can be achieved through the use of a match filter approach. For realistic cases, this filter must be adapted to handle spatial and temporal variations of the splitting signature. The resulting attributes suggest that further insights into the reservoir properties can be found.
Unified description and validation of Monte Carlo simulators in PET (2005)

Several Monte Carlo simulators are currently available for positron emission tomography (PET). Because each code has been described in a different way, it is difficult to know which one is best suited to a specific application. To help clarify the capabilities and accuracy of different codes dedicated to PET simulations, we propose a uniform description of the code features. This description specifies features pertaining to the models used for simulating the physics of PET and for describing a PET acquisition, to the acceleration strategies and to the technical characteristics of the code implementation. To assess the code accuracy, we suggest validation procedures based on NEMA phantoms involving standard physical parameters and simulation of a complex activity distribution. A test characterizing the statistical properties of detected coincidences is also described. The proposed code description and validation procedures are illustrated by considering the SimSET and PET-EGS codes. These codes differ in many features, including models for randoms and dead time, and source description. Despite these differences, both codes yielded data with properties close to those of real data. Depending on the intended application, one code might be preferred however. Indeed, only PET-EGS allows for accurate modelling of count rates while SimSET is more computationally efficient. The proposed code description and validation procedures might help determine which code is most appropriate for a specific application.
Biomechanical evaluation of an expansive pedicle screw in calf vertebrae. (2005)

EPS can significantly improve the bone purchase and the pull-out strength compared to USS, Tenor and CDH screws with similar dimensions before and after failure simulation. The fatigue characteristic of EPS is similar to that of CDH, USS and Tenor screws.
Biological Correlates of p27 Compartmental Expression in Prostate Cancer (2006)

We report that p27 expression is consistently high in the normal prostate. Moderate levels of nuclear p27 and/or cytoplasmic entrapment of p27 are associated with increased proliferation and worse biochemical recurrence-free survival. These findings suggest that PCa may enhance its growth and progression by decreasing nuclear p27 via cytoplasmic displacement and other molecular mechanisms.
Accommodating color blind computer users (2006)

Important visual information often disappears when color documents are viewed by color blind people. The algorithm introduced here maps colors using the World Wide Web Consortium evaluation criteria so that detail is preserved for color blind viewers, especially dichromats. The algorithm has four parts: 1) select a representative set of colors from the source document; 2) compute target color distances using color and brightness differences; 3) solve an optimization step that preserves the target distances for a particular class of color blind viewer; and 4) interpolate the mapped colors across the remaining colors in the document. We demonstrate the efficacy of our method using simulations and critique our method in the context of earlier work.
[Predictive evaluation and efficient management of medical examinations using Mahalanobis Taguchi System Method]. (1999)

These results suggest that the Mahalanobis-Taguchi System technique can accurately assess medical examination quality and can also be used, with reasonable accuracy, to predict the condition of individuals one year later. Therefore, the MTS can be used to help determine which patients should be receiving the examination 1 year later. In addition, components of the examination can be assessed using the MTS for benefits and costs to determine levels of essentiality of components. As a result, it can be used an effective tool for development and improvements in the examination system. With further development in the technique, it may become possible for use as a tool in disease diagnosis and treatment.
miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development (2017)

MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-coding RNAs, 19-3 nucleotides in length, that negatively regulate protein coding gene transcripts' expression. miR-146 (146a and 146b) and miR-155 are among the first and most studied miRs for their multiple roles in the control of the innate and adaptive immune processes and for their deregulation and oncogenic role in some tumors. In the present review, we have focused on the recent acquisitions about the key role played by miR-146a, miR-146b and miR-155 in the control of the immune system and in myeloid tumorigenesis. Growing experimental evidence indicates an opposite role of miR-146a with respect to miR-155 in the fine regulation of many steps of the immune response, acting at the level of the various cell types involved in innate and adaptive immune mechanisms. The demonstration that miR-155 overexpression plays a key pathogenic role in some lymphomas and acute myeloid leukemias has led to the development of an antagomir-based approach as a new promising therapeutic strategy.
Short-duration pulse radar experimental system integration and basic experimental research on the target detection (2002)

The concept of high power microwave (HPM) short-duration pulse radar may have possibilities with the rapid development of HPM techniques. Short-duration pulse HPM radar has the advantages of high ECCM ability long range detection ability, high range resolution and high ability to detect targets in heavy scatter backgrounds. The DSP method is relatively simple. In this paper, the function, structure and constitution of a short-duration pulse radar experimental system which has been developed is presented. A method for creating, transmitting and receiving the short-duration pulse microwave signal is explored. A high range-resolution detection experiment for an air target and ground target is also preliminarily studied.
Entanglement generation in a quantum network with finite quantum memory lifetime (2022)

We simulate entanglement sharing between two end-nodes of a linear chain quantum network using SeQUeNCe, an open-source simulation package for quantum networks. Our focus is on the rate of entanglement generation between the end-nodes with many repeaters with a finite quantum memory lifetime. Numerical and analytical simulations show limits of connection performance for a given number of repeaters involved, memory lifetimes, the distance between the end-nodes, and an entanglement management protocol. Our findings demonstrate that the performance of quantum connection depends highly on the entanglement management protocol, which schedules entanglement generation and swapping, resulting in the final end-to-end entanglement.
Novel chimeras of botulinum and tetanus neurotoxins yield insights into their distinct sites of neuroparalysis (2012)

Botulinum neurotoxin (BoNT) A or E and tetanus toxin (TeTx) bind to motor-nerve endings and undergo distinct trafficking; their light-chain (LC) proteases cleave soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) peripherally or centrally and cause flaccid or spastic paralysis, respectively. To seek protein domains responsible for local blockade of transmitter release (BoNTs) rather than retroaxonal transport to spinal neurons (TeTx), their acceptor-binding moieties (H(C))--or in one case, heavy chain (HC)--were exchanged by gene recombination. Each chimera, expressed and purified from Escherichia coli, entered rat cerebellar neurons to cleave their substrates, blocked in vitro nerve-induced muscle contractions, and produced only flaccid paralysis in mice. Thus, the local cytosolic delivery of BoNT/A or BoNT/E proteases and the contrasting retrograde transport of TeTx are not specified solely by their HC or H(C); BoNT/A LC translocated locally irrespective of being targeted by either of the latter TeTx domains. In contrast, BoNT/E protease fused to a TeTx enzymatically inactive mutant (TeTIM) caused spastic paralysis and cleaved SNAP-25 in spinal cord but not the injected muscle. Apparently, TeTIM precludes cytosolic release of BoNT/E protease at motor nerve endings. It is deduced that the LCs of the toxins, acting in conjunction with HC domains, dictate their local or distant destinations.
Digital presentations: make your delivery effective (1998)

Beaucoup de gens doivent faire des presentations en public, que ce osit pour des cours, des demonstrations, des formations. L'auteur suggere quelques conseils a ne pas negliger si vous utiliser des technologies electroniques. Ou comment ne pas gâcher un contenu interessant par une presentation mediocre
Protein Conformational Changes Induced by 1,1'-Bis(4-anilino-5-naphthalenesulfonic acid): Preferential Binding to the Molten Globule of DnaK (1994)

1,1'-Bis(4-anilino-5-naphthalenesulfonic acid) (bis-ANS), a hydrophobic fluorescent molecular probe which has been shown to bind to compact intermediate states of proteins (molten globules) and also to many nucleotide binding sites, induces a conformational change in DnaK by preferentially binding to its partially folded intermediate state (I) and thus shifting the equilibrium from favoring the native state (N) to favoring the I state. The conformational change was detected by CD, fluorescence emission, size exclusion chromatography, and small-angle X-ray scattering. The presence of bis-ANS significantly decreases the midpoint, Tm, of the initial transition (N-->I) in the thermal unfolding of DnaK, resulting in the apparent destabilization of the native state of DnaK. There is a linear correlation between the apparent free energy (reflected by Tm) of this transition and the concentration of bis-ANS. Bis-ANS does not affect the midpoint of the transition for DnaK from the intermediate to the unfolded state (U). An additional small transition from I to I*, a more expanded intermediate state, was observed, suggesting that the thermal denaturation of DnaK proceeds via a four-state (N-->I-->I*-->U) unfolding process. The addition of nucleotides, ADP or ATP, to the DnaK-bis-ANS complex causes a decrease in bis-ANS fluorescence emission due to the release of bound bis-ANS from the intermediate state of DnaK. This is due to preferential binding of the nucleotide to the native state of DnaK, resulting in a shift in the equilibrium from the intermediate toward the native state rather than the direct displacement of bis-ANS bound in the nucleotide binding site. Denaturation of DnaK induced by bis-ANS can be minimized by working at a temperature much lower than the Tm of the protein, at low dye concentration, and in the presence of nucleotide. Under these conditions, bis-ANS binds to the native state of DnaK.
Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's disease (2003)

Plasma phospholipid transfer protein (PLTP) is one of the key proteins in lipid and lipoprotein metabolism. We examined PLTP distribution in human brain using PLTP mRNA dot-blot, Northern blot, immunohistochemistry (IHC), Western blot, and phospholipid transfer activity assay analyses. PLTP mRNA of 1.8 kb was widely distributed in all the examined regions of the central nervous system at either comparable or slightly lower levels than in the other major organs, depending on the region. Cerebrospinal fluid phospholipid transfer activity represented 15% of the plasma activity, indicating active PLTP synthesis in the brain. Western blot and phosholipid transfer activity assay demonstrated secretion of active PLTP by neurons, microglia, and astrocytes in culture. IHC demonstrated PLTP presence in neurons, astrocytes, microglia, and oligodendroglia. Some neuronal groups, such as nucleus hypoglossus and CA2 neurons in hippocampus, ependymal layer, and choroid plexus were particularly strongly stained, with substantial glial and neuropil immunostaining throughout the brain. Comparison between brain tissues from patients with Alzheimer's disease (AD) and nonAD subjects revealed a significant increase (P = 0.02) in PLTP levels in brain tissue homogenates and increased PLTP immunostaining in AD.
Asymmetric Inter‐ and Intramolecular Cyclopropanation Reactions Catalyzed by a Reusable Macroporous‐Polymer‐Supported Chiral Ruthenium(II)/Phenyloxazoline Complex (2010)

Along came poly: A novel macroporous polymer-supported chiral RuII/pheox catalyst (1, see SEM image) afforded excellent reactivity and enantioselectivity in inter- and intramolecular cyclopropanation reactions with a broad range of substrates. The catalyst showed no leaching and could be reused up to 11 times, even after storage.
A general class of aggregation operators with applications to information fusion in distributed systems (2003)

A collection of all plausible solutions to a given complex problem is considered, and it is assumed that these solutions are separately ranked by the degree to which they satisfy each member of an a priori chosen criteria set. Oftentimes these rankings can be accurately modeled as partial orders. Given such a collection of partially ordered sets (posets), one may wish to define a class of operators whose members may be used to aggregate this collection of posets into a single poset. Selection of a solution to the given problem can then be performed on this poset directly. The authors propose a framework that allows the construction of a variety of aggregation operators so as to bring forth their algebraic structure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Integrating fluxmeter with digital readout (1970)

A true integrating electronic fluxmeter with digital readout has been developed. It is a solid-state device, stable over a wide range of environments, and is free of zeroing and vibration problems. When measuring flux, using a search coil, the traditional integration of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N \phi = 10^{8} \int e dt</tex> is here performed by a voltage-to-frequency converter (VFC) which produces a series of output pulses, the number of which is proportional to <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\int e dt</tex> . These pulses are summed on a digital counter, and the indication thus obtained is a measure of the flux change. Calibration is readily performed by direct reference to the basic standards of the volt and the second, an important feature of this fluxmeter. This is in contrast to the generally used secondary standards of mutual inductance and current shunt millivolt drop. Enhancing this direct traceability is the constant digital readout, eliminating reading errors caused by a moving light beam. The basic accuracy of integration can be 0.15 percent or less.
Imaging Seismic Deformation Induced by Hydraulic Fracture Complexity (2009)

Summary Microseismic mapping is extensively used in the Barnett Shale to map hydraulic fracture complexity associated with interactions of the stimulation with pre-existing fractures (fracs). Previous studies have indicated a fair correlation between the well performance and extent of the seismically active volume. However, in addition to this measure of the extent of the stimulated fracture network, the characteristics of this fracture network is also expected to impact the well performance. In particular, the fracture spacing is believed to be an important factor controlling the potential gas flow. In this paper, we use the density of the total seismic moment release (a robust measure of the microseism strength) as an indication of the seismic deformation that may correlate to the fracture density. The study uses a set of microseismic maps of hydraulic fracture stimulations, including cases in which the stimulated reservoir volume measured by the extent of the seismically active region poorly correlated with the well performance. Incorporating the seismic moment density to assess the fracture density with the network extent, an improved correlation with the well performance was observed.
Microencapsulation of Ethion by Interfacial Polymerization Utilizing Potassium Phthalimide-N-oxyl (PPINO) as a Promoter (2011)

Polyurea microcapsules containing an active agent, i.e. ethion as pesticide, have been prepared by interfacial polymerization between 2, 4-toluene diisocyanate (TDI) and diethylenetriamine (DETA) in an oil-in-water (O/W) emulsion system. The effects of the nature of the emulsifier, the monomer weight ratio, and a novel promoter, i.e. potassium phthalimide-N-oxyl (PPINO), on the morphology, microstructure, and thermal stability of the microcapsules have been investigated. PPINO was used as a water-soluble promoter capable of dimerizing and trimerizing the isocyanate reactant in the interfacial polymerization. The transmission electron microscopy (TEM) micrographs showed that the addition of the promoter had no significant effect on the microcapsule shell thickness. Increasing the amount of PPINO caused the degree of crystallinity of the polymer shell to decrease considerably. In addition, increasing the amount of promoter up to 2 wt% caused the thermal stability of the microcapsules to decrease, while using promoter beyond this level resulted in higher thermal stability.