gebhart/patrepeval huggingface dataset:
Growth of Semiconducting Graphene on Palladium (2009)

We report in situ scanning tunneling microscopy studies of graphene growth on Pd(111) during ethylene deposition at temperatures between 723 and 1023 K. We observe the formation of monolayer graphene islands, 200-2000 A in size, bounded by Pd surface steps. Surprisingly, the topographic image contrast from graphene islands reverses with tunneling bias, suggesting a semiconducting behavior. Scanning tunneling spectroscopy measurements confirm that the graphene islands are semiconducting, with a band gap of 0.3 +/- 0.1 eV. On the basis of density functional theory calculations, we suggest that the opening of a band gap is due to the strong interaction between graphene and the Pd substrate. Our findings point to the possibility of preparing semiconducting graphene layers for future carbon-based nanoelectronic devices via direct deposition onto strongly interacting substrates.
Mass Spectra of the Hydroxyindole-3-carboxylic Acids and the Hydroxyskatoles (1971)

The electron impact fragmentations of the 4-, 5-, 6-, and 7-hydroxyskatoles and the 4-, 5-, 6-, and 7-hydroxyindole-3-carboxylic acids have been studied. The spectra of the four isomeric hydroxyskatoles are virtually indistinguishable, due to substituent randomization of the [M] and [M-1] ions. In the case of the hydroxyindole-3-carboxylic acids, loss of H 2 O from the molecular ion is characteristic of the 4-isomer but initial loss of •OH from the molecular ion is the most important reaction of the other three isomers.
Auditory Brainstem Correlates of Perceptual Timing Deficits (2007)

Children with language-based learning problems often exhibit pronounced speech perception difficulties. Specifically, these children have increased difficulty separating brief sounds occurring in rapid succession (temporal resolution). The purpose of this study was to better understand the consequences of auditory temporal resolution deficits from the perspective of the neural encoding of speech. The findings provide evidence that sensory processes relevant to cognition take place at much earlier levels than traditionally believed. Thresholds from a psychophysical backward masking task were used to divide children into groups with good and poor temporal resolution. Speech-evoked brainstem responses were analyzed across groups to measure the neural integrity of stimulus-time mechanisms. Results suggest that children with poor temporal resolution do not have an overall neural processing deficit, but rather a deficit specific to the encoding of certain acoustic cues in speech. Speech understanding relies on the ability to attach meaning to rapidly fluctuating changes of both the temporal and spectral information found in consonants and vowels. For this to happen properly, the auditory system must first accurately encode these time-varying acoustic cues. Speech perception difficulties that often co-occur in children with poor temporal resolution may originate as a neural encoding deficit in structures as early as the auditory brainstem. Thus, speech-evoked brainstem responses are a biological marker for auditory temporal processing ability.
The preparation of leukocyte‐poor red blood cells: a comparative study (1980)

Thirteen methods of prepararing leukocyte-poor red blood cells were compared for their effectiveness in removing leukocytes. When the starting material was six to ten days old, the residual leukocyte count was three to four times lower than when fresh material was used and no granulocytes could be found. The most effective manual procedure was a single upright sedimentation of six- to ten-day-old saline-diluted red cells. Inverted sedimentation was no more effective in leukocyte depletion than upright sedimentation. Automated cell processors were no more effective than several of the better manual methods. Freezing and deglycerolizing resulted in a ten-fold improvement in leukocyte removal with less red blood cell loss but at higher cost than the nonfreezing methods. The study indicates that unless the minimal leukocyte count of frozen red blood cells is essential, a single upright sedimentation of saline-diluted, six- to ten-day-old red blood cells is currently the most effective procedure for preparing leukocyte-poor red blood cells.
Prediction of the <i>Candida antarctica</i> Lipase A Protein Structure by Comparative Modeling and Site‐Directed Mutagenesis (2007)

A number of model structures of the CalA suggested by comparative modeling were tested by site-directed mutagenesis. Enzyme variants were created where amino acids predicted to play key roles for the lipase activity in the different models were replaced by an inert amino acid (alanine). The results from activity measurements of the overproduced and purified mutant enzymes indicate a structure where the active site consists of amino acid residues Ser184, His366, and Asp334 and in which there is no lid. This model can be used for future targeted modifications of the enzyme to obtain new substrate acceptance, better thermostability, and higher enantioselectivity.
[Assessment of the risk of expansion of the habitats of the mosquitoes AEDES aegypti L. and Aedes albopictus Skus. in Russia]. (2015)

Based on climatic characteristics, the authors show that an invasive Aedes albopictus species is likely to emerge in new areas of the Russian Federation.
Epitaxial ordering of oxide superconductor thin films on (100) SrTiO3 prepared by pulsed laser evaporation (1987)

Thin films of Y-Ba-Cu-O superconductors on (100) SrTiO3 were prepared using the pulsed excimer laser evaporation technique. After an annealing treatment in oxygen the films exhibited superconductivity with zero resistance at 85 K with transition widths (90%–10%) as narrow as a 2 K. A considerable amount of orientation of the films with respect to the substrates was observed by x-ray diffraction and ion channeling techniques. Interface reaction revealed by Rutherford backscattering and Auger electron spectrometry resulted in a thickness dependence of the superconducting properties of the films.
A Practical Visual Servo Control for an Unmanned Aerial Vehicle (2008)

An image-based visual servo control is presented for an unmanned aerial vehicle (UAV) capable of stationary or quasi-stationary flight with the camera mounted onboard the vehicle. The target considered consists of a finite set of stationary and disjoint points lying in a plane. Control of the position and orientation dynamics is decoupled using a visual error based on spherical centroid data, along with estimations of the linear velocity and the gravitational inertial direction extracted from image features and an embedded inertial measurement unit. The visual error used compensates for poor conditioning of the image Jacobian matrix by introducing a nonhomogeneous gain term adapted to the visual sensitivity of the error measurements. A nonlinear controller, that ensures exponential convergence of the system considered, is derived for the full dynamics of the system using control Lyapunov function design techniques. Experimental results on a quadrotor UAV, developed by the French Atomic Energy Commission, demonstrate the robustness and performance of the proposed control strategy.
A Biometric Key Generation Method Based on Semisupervised Data Clustering (2015)

Storing biometric templates and/or encryption keys, as adopted in traditional biometrics-based authentication methods, has raised a matter of serious concern. To address such a concern, biometric key generation, which derives encryption keys directly from statistical features of biometric data, has emerged to be a promising approach. Existing methods of this approach, however, are generally unable to appropriately model user variations, making them difficult to produce consistent and discriminative keys of high entropy for authentication purposes. This paper develops a semisupervised clustering scheme, which is optimized through a niching memetic algorithm, to effectively and simultaneously model both intra- and interuser variations. The developed scheme is employed to model the user variations on both single features and feature subsets with the purpose of recovering a large number of consistent and discriminative feature elements for key generation. Moreover, the scheme is designed to output a large number of clusters, thus further assisting in producing long while consistent and discriminative keys. Based on this scheme, a biometric key generation method is finally proposed. The performance of the proposed method has been evaluated on the biometric modality of handwritten signatures and compared with existing methods. The results show that our method can deliver consistent and discriminative keys of high entropy, outperforming-related methods.
Specific Binding of Peroxidase-Labeled Myelin Basic Protein in Allergic Encephalomyelitis (1971)

A conjugate of horseradish peroxidase and the encephalitogenic basic protein from myelin has been used to study the antigen reactivity of tissue in the autoimmune disease, experimental allergic encephalomyelitis. Control conjugates were also prepared of peroxidase and bovine serum albumin and of peroxidase and lysozyme, another basic protein. The basic protein from myelin conjugate was specifically bound by lymph node cells from rabbits immunized against the basic protein. Some of these cells appeared to be plasma cells. The conjugate was also specifically bound by occasional cells in the spinal-cord infiltrates of animals with early signs of allergic encephalomyelitis. These cells resembled large lymphocytes and plasma cells. There was no difference between the binding of basic protein of bovine and rabbit origin. The findings suggest the possibility that a local release of antibody within the target organ may play a role in the pathogenesis of allergic encephalomyelitis.
Late effects of locally delivered mitomycin C on formation of neointima and on vasomotor response to acetylcholine (1994)

Local delivery of mitomycin C had no favorable effect on the inhibition of intimal hyperplasia compared with control saline-treated arteries. Normal endothelial function, determined on the basis of dilatory response to acetylcholine, can be demonstrated 7 weeks after balloon angioplasty injury.
Comparison of cardiac monophasic action potentials recorded by intracellular and suction electrodes (1959)

The action potentials recorded from heart muscle with a suction electrode have been compared to those recorded with an intracellular microelectrode. It has been found that if the suction electrode is properly used the monophasic potentials recorded with it may be taken as a reliable index of the time of arrival of excitation at the electrode and as a reliable index of the shape of the action potential during the entire phase of repolarization. The suction electrode potentials differ from the microelectrode potentials in showing a lower rise velocity, a smaller amplitude, a quantitatively different reversal or overshoot and, in the beating heart, ‘afterpotentials’ caused by mechanical effects. When the shape of the action potential, as observed with the microelectrode, is changed by ions such as K + or Ca ++ a similar change is observed in the potential recorded with the suction electrodes.
Marginal Structural Models and Causal Inference in Epidemiology (2000)

In observational studies with exposures or treatments that vary over time, standard approaches for adjustment of confounding are biased when there exist time-dependent confounders that are also affected by previous treatment. This paper introduces marginal structural models, a new class of causal models that allow for improved adjustment of confounding in those situations. The parameters of a marginal structural model can be consistently estimated using a new class of estimators, the inverse-probability-of-treatment weighted estimators.
Direct synthesis of large-scale hierarchical MoS<sub>2</sub> films nanostructured with orthogonally oriented vertically and horizontally aligned layers (2015)

Correction for 'Direct synthesis of large-scale hierarchical MoS2 films nanostructured with orthogonally oriented vertically and horizontally aligned layers' by Xiaoyan Zhang et al., Nanoscale, 2016, DOI: 10.1039/c5nr05938k.
AV-65, a novel Wnt/β-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model (2011)

Multiple myeloma (MM) is a malignant neoplasm of plasma cells. Although new molecular targeting agents against MM have been developed based on the better understanding of the underlying pathogenesis, MM still remains an incurable disease. We previously demonstrated that β-catenin, a downstream effector in the Wnt pathway, is a potential target in MM using RNA interference in an in vivo experimental mouse model. In this study, we have screened a library of more than 100 000 small-molecule chemical compounds for novel Wnt/β-catenin signaling inhibitors using a high-throughput transcriptional screening technology. We identified AV-65, which diminished β-catenin protein levels and T-cell factor transcriptional activity. AV-65 then decreased c-myc, cyclin D1 and survivin expression, resulting in the inhibition of MM cell proliferation through the apoptotic pathway. AV-65 treatment prolonged the survival of MM-bearing mice. These findings indicate that this compound represents a novel and attractive therapeutic agent against MM. This study also illustrates the potential of high-throughput transcriptional screening to identify candidates for anticancer drug discovery.
Molecular Cloning and Expression of the KIF3A Gene in the Frog Brain and Testis (1997)

KIF3A is a member of the kinesin superfamily proteins (KIFs), but its gene has been cloned only in mouse and sea urchin. We have cloned a homolog of KIF3A from the frog, Rana rugosa (rrKIF3A). The sequence encoded a 699 amino acid protein that shares 93% similarity with mouse KIF3A (mKIF3A) and 69% with sea urchin kinesin-related protein (SpKRP85). The putative ATP-binding domain was completely identical to that of mKIF3A and SpKRP85. The level of rrKIF3A mRNA appeared to be high in the brain and testis of adult frogs, but low in the heart, lung and kidney. The results suggest that the rrKIF3A gene is expressed in the brain and testis more than other tissues of adult frogs examined, and that KIF3A is widely distributed in eukaryotic organisms.
All optical 8-channel wavelength division demultiplexer based on photonic crystal ring resonators (2017)

In this paper we are going to propose an 8 channel all optical wavelength division demultiplexer. For this purpose first of all we will proposed and design a channel drop filter based on photonic crystal ring resonator. Then generalize the proposed filter into an 8 channel optical demultiplexer. The obtained desmultiplxer has average band width about 2.5 nm. The minimum transmission efficiency is about 79% and the crosstalk values vary between −12 dB and −40 dB.
ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling (2012)

Two distinct types of Flk-1(+) mesoderm, hemangiogenic and cardiogenic, are thought to contribute to blood, vessel, and cardiac cell lineages. However, our understanding of how Flk-1(+) mesoderm is specified is currently limited. In the present study, we investigated whether ER71, an Ets transcription factor essential for hematopoietic and endothelial cell lineage development, could modulate the hemangiogenic or cardiogenic outcome of the Flk-1(+) mesoderm. We show that Flk-1(+) mesoderm can be divided into Flk-1(+)PDGFRα(-) hemangiogenic and Flk-1(+)PDGFRα(+) cardiogenic mesoderm. ER71-deficient embryonic stem cells produced only the Flk-1(+)PDGFRα(+) cardiogenic mesoderm, which generated SMCs and cardiomyocytes. Enforced ER71 expression in the wild-type embryonic stem cells skewed toward the Flk-1(+)PDGFRα(-) mesoderm formation, which generated hematopoietic and endothelial cells. Whereas hematopoietic and endothelial cell genes were positively regulated by ER71, cardiac and Wnt signaling pathway genes were negatively regulated by ER71. We show that ER71 could inhibit Wnt signaling in VE-cadherin-independent as well as VE-cadherin-dependent VE-cadherin/β-catenin/Flk-1 complex formation. Enforced β-catenin could rescue cardiogenic mesoderm in the context of ER71 overexpression. In contrast, ER71-deficient Flk-1(+) mesoderm displayed enhanced Wnt signaling, which was reduced by ER71 re-introduction. We provide the molecular basis for the antagonistic relationship between hemangiogenic and cardiogenic mesoderm specification by ER71 and Wnt signaling.
A Light and Electron Microscopic Anterograde WGA-HRP Tracing Study on the Sensory Innervation of Junctional and Sulcular Epithelium in the Rat Molar (1992)

The sensory innervation of junctional and oral sulcular epithelium was investigated by use of anterograde transport of wheat-germ agglutinin-horseradish peroxidase from the trigeminal ganglion. By light microscopy, labeled intra-epithelial nerve fibers were observed forming a dense plexus in the apical two-thirds of the junctional epithelium, with some fibers located near the enamel space. Occasional fibers extended coronally to the sulcus bottom. By electron microscopy, labeled intra-epithelial axon terminals or varicosities were demonstrated to be in close contact with both junctional epithelial cells and neutrophils. These varicosities, which were occasionally surrounded by the cytoplasmic processes of epithelial cells or neutrophils, frequently contained large granular and small clear vesicles. In contrast to the junctional epithelium, the oral sulcular epithelium was sparsely innervated, except for the transition region between the oral sulcular epithelium and the junctional epithelium, where a dense innervation by labeled intraepithelial fibers was found. These fibers extended as far as the stratum spinosum. Electron microscopy revealed mitochondria-filled profiles of varicosities between epithelial cells. This study shows differences in the distribution and ultrastructure of sensory nerves between the junctional and oral sulcular epithelia, and further provides morphological evidence that sensory nerves in the junctional epithelium come into contact not only with epithelial cells but also with neutrophils.
Probing the Binding of Indolactam-V to Protein Kinase C through Site-Directed Mutagenesis and Computational Docking Simulations (1999)

Protein kinase C (PKC) comprises a family of ubiquitous enzymes transducing signals by the lipophilic second messenger sn-1, 2-diacylglycerol (DAG). Teleocidin and its structurally simpler congener indolactam-V (ILV) bind to PKC with high affinity. In this paper, we report our computational docking studies on ILV binding to PKC using an automatic docking computer program, MCDOCK. In addition, we used site-directed mutagenesis to assess the quantitative contribution of crucial residues around the binding site of PKC to the binding affinity of ILV to PKC. On the basis of the docking studies, ILV binds to PKC in its cis-twist conformation and forms a number of optimal hydrogen bond interactions. In addition, the hydrophobic groups in ILV form "specific" hydrophobic interactions with side chains of a number of conserved hydrophobic residues in PKC. The predicted binding mode for ILV is entirely consistent with known structure-activity relationships and with our mutational analysis. Our mutational analysis establishes the quantitative contributions of a number of conserved residues to the binding of PKC to ILV. Taken together, our computational docking simulations and analysis by site-directed mutagenesis provide a clear understanding of the interaction between ILV and PKC and the structural basis for design of novel, high-affinity, and isozyme-selective PKC ligands.
Some Recent Topics of Non-equilibrium Discharge Plasma Technologies - Their Widespread Use from Low Pressure to Atmospheric Pressure (2007)

Non-equilibrium discharge plasmas have been utilized in a variety of fields and are indispensable to material processing, nanotechnologies and biotechnologies besides conventional applications such as light sources. In this review, neutral beam etching, advanced oxidation, protein removal, combustion control and volume, non-equilibrium discharge generation at atmospheric pressure are chosen and summarized as the recent, typical applications of the non-equilibrium discharge plasmas generated from low pressure to atmospheric pressure. A brief introduction of non-equilibrium discharge plasmas is also given, which serves comprehensive understanding of the physics and chemistry behind the technology.
On-Chip Neural Data Compression Based On Compressed Sensing With Sparse Sensing Matrices (2018)

On-chip neural data compression is an enabling technique for wireless neural interfaces that suffer from insufficient bandwidth and power budgets to transmit the raw data. The data compression algorithm and its implementation should be power and area efficient and functionally reliable over different datasets. Compressed sensing is an emerging technique that has been applied to compress various neurophysiological data. However, the state-of-the-art compressed sensing (CS) encoders leverage random but dense binary measurement matrices, which incur substantial implementation costs on both power and area that could offset the benefits from the reduced wireless data rate. In this paper, we propose two CS encoder designs based on sparse measurement matrices that could lead to efficient hardware implementation. Specifically, two different approaches for the construction of sparse measurement matrices, i.e., the deterministic quasi-cyclic array code (QCAC) matrix and -sparse random binary matrix [-SRBM] are exploited. We demonstrate that the proposed CS encoders lead to comparable recovery performance. And efficient VLSI architecture designs are proposed for QCAC-CS and -SRBM encoders with reduced area and total power consumption.
Bus scheduling for a multiple-processor system with shared buses (1987)

The operation and performance of a multiple-processor system with shared buses is analysed. The model developed is applicable to real-time computations consisting of two pipelined tasks in which the first task is partitioned into a number of independent subtasks on separate processors. These processors transmit their output data to the processor(s) executing the second task over shared buses. When the system has a single shared bus, it is shown that its operation becomes periodic after a number of task executions. Expressions for the cycle time and the system throughput are derived. Two schemes are then proposed for scheduling the data transmissions on a multiple-bus system so as to minimise the corresponding cycle times. The computational complexity of the scheduling problems is studied, and exact, approximate and heuristic algorithms are developed for their solution.
An Online Learning Community Integrated with Web-Enhanced Collaborative Learning and Self-Regulated Learning (2011)

This paper investigates two aspects of the growing trend towards collaborative learning (CL) and self-regulated learning (SRL) in higher education by examining students’ computing skills in a blended learning environment. The author redesigned a course and adopted web-enhanced CL and SRL to develop undergraduates’ computing skills of web page programming and website building. Three classes with 170 students in a one-semester course were chosen for the empirical study. The results in this study show that students who received web-enhanced CL and SRL had higher grades than those who did not receive web-enhanced CL and/or SRL. It can provide references for schools and teachers who plan to provide online or blended courses for their students to achieve better learning effects in web-based learning environments.