gebhart/patrepeval huggingface dataset:
Advanced passive safety system via prediction and sensor fusion (2002)

This paper describes a new method that employs a proximity sensor to detect a frontal collision by which the reliability of the whole automotive air bag system is expected to be greatly improved. To build the highly accurate and highly reliable systems, we must consider the following problems: 1) the air bag system can detect accurately whether the automobile collides to an obstacle; 2) the system can judge quantitatively whether the air bag should be triggered; and 3) when the air bag must be triggered, the system can expand the bag at the optimal timing. To solve the above problems, the following five processing blocks are prepared: 1) accurate detection of frontal collision; 2) estimation of both the acceleration and jerk from noisy measured acceleration by Luenberger observer; 3) filtering to estimate the velocity and displacement of the occupant's motion; 4) prediction of the velocity and displacement of the occupant's motion; and 5) judgement to trigger the air bag.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effect of Intrusion Detection and Response on Reliability of Cyber Physical Systems (2013)

In this paper we analyze the effect of intrusion detection and response on the reliability of a cyber physical system (CPS) comprising sensors, actuators, control units, and physical objects for controlling and protecting a physical infrastructure. We develop a probability model based on stochastic Petri nets to describe the behavior of the CPS in the presence of both malicious nodes exhibiting a range of attacker behaviors, and an intrusion detection and response system (IDRS) for detecting and responding to malicious events at runtime. Our results indicate that adjusting detection and response strength in response to attacker strength and behavior detected can significantly improve the reliability of the CPS. We report numerical data for a CPS subject to persistent, random and insidious attacks with physical interpretations given.
Composition and value of returned consumer and industrial information technology equipment (2002)

Due to continuing technological advances, information technology (IT) equipment has maintained an ever decreasing product lifecycle. In the industrial sector, this usually means a rapid turnover of recent vintage computer systems that are loaded with still remarketable parts and assemblies. In the consumer sector, this rapid turnover coupled with consumer reluctance to discard their outdated equipment, has resulted in the return of aged systems of questionable value. Therefore, as systems are returned to remanufacturing or demanufacturing centers, it becomes key to understand the compositional make-up and characteristics of the systems so that the "breakpoints" of value for resale, parts recovery, or commodity and material disposal options are known. This paper first presents data obtained from characterizing a sample of returns of IBM(R) equipment from the industrial sector. Items such as resale value, expected parts recovery value, and strict material recovery by system vintage are highlighted. Second, data characterizing returns on systems collected during a community personal computer takeback offering is presented. Items such as product composition by component and weight, processor technology, and monitor/display conditions are discussed.
Pipeline Leak Detection Using Four Mode Fibre-Optic Based Distributed Sensing (2014)

Fibre-optic based Distributed Acoustic Sensing (DAS), is now commonly used around the world for providing pipeline operators with real-time and early warning of intrusions on their pipeline Right of Ways. Also open to analysis within the DAS signal return are multiple signatures derived from the egress of product leaking from pipelines. Over the last three years, focussing attention on these alternative signals, OptaSense have developed a novel 4-mode External Leak Detection capability, fusing outputs from both DAS, Negative Pressure Pulse (NPP) and Distributed Temperature Gradient Sensing (DTGS) signals (the latter not to be confused with Distributed Temperature Sensing or DTS). The first commercially deployed 4-mode Leak Detection products are now being seen on the market, for both gas and liquids pipelines. In this paper, we report how DAS can be used to provide these four modes of leak detection — including (listed in order of typical detection latency, fastest to slowest) i) negative pressure waves created in the pipeline product from the leak event ii) acoustic noise from turbulent flow through the leak orifice iii) temperature gradients in the soil due to the presence of the leaked product (positive and negative), and iv) local strain/ground heave due to soil displacement by the leaked product. These acoustic, temperature and strain measurements using a fibre-optic cable buried next to a pipeline can be fused together to provide highly sensitive and reliable alerts for pipeline leaks. The pipeline industry has always sought to detect smaller leaks faster, with better locational accuracy. This paper, which draws upon industry sponsored test results and commercial deployment data, provides an update to the industry on leak detection possibilities using DAS.
Inhibition of Babesia divergens in cattle by oxytetracycline (1986)

The effects of continuous oxytetracycline administration on the development of parasitaemia of Babesia divergens during both natural and artificial infections were studied. During natural exposure on grazing heavily infested with Ixodes ricinus, seven out of 42 cattle with no previous exposure to tick-borne diseases were injected every four days with a long acting preparation of oxytetracycline at a dose rate of 20 mg/kg. During the six week grazing period 21 untreated cattle developed a patent parasitaemia of B divergens and all became seropositive by the fluorescent antibody test. In contrast, no parasites were observed in treated cattle and antibody titres remained low. Artificial infections were studied with different dose levels of oxytetracycline and their effects on antibody stimulation noted. First, four groups of cows were infected with 10(8) erythrocytes infected with B divergens, three groups being injected every four days with the long acting oxytetracycline formulation at dose levels of 20, 10 and 5 mg/kg, respectively. The highest level completely inhibited parasite replication and antibody formation; the same was observed in one animal dosed at 10 mg/kg but the remainder, plus those treated at 5 mg/kg, developed both low parasitaemia and high antibody titres. The untreated cows developed severe babesiosis. A further untreated control group was added and three weeks after cessation of oxytetracycline treatment all were infected with 10(9) erythrocytes infected with a homologous isolate of B divergens. The controls, plus those in which the previous infection had been completely inhibited, developed severe clinical babesiosis but the remainder were refractory to parasite development.
Solid-State Laser Intra-Cavity Photothermal Sensor (SLIPS) for Gas Detection with Parts-Per-Billion Sensitivity (2022)

We report a novel, miniaturized gas sensor configuration with ppbv (parts-per-billion by volume) sensitivity, where detection of the gas sample concentration is realized inside a Nd:YVO 4 /YVO 4 / Air-Gap structure (2 2 14 mm 3 ) of the double-beam, monolithic diode-pumped solid-state laser (DPSSL) resonator operating at 1064 nm. Both generated probe and reference beams are passed through an ultra-compact sensing volume (4 L) of the air-gap section filled with gas molecules. Simultaneously, an auxiliary laser beam is targeted on the absorption line of a measured gas sample and focused on a 1064 nm probe beam only. Due to the absorption effect, excited gas molecules are heated locally, resulting in a negligible change in a gas refractive index (RI), which is inherent to the photothermal effect (PT). Hence, the PT-induced variations of the gas RI inside the laser resonator are modulating the optical path-length of the probe beam, which resulted in a significant optical frequency shift of the probe beam against the reference one. The optical frequency changes were measured by applying the heterodyne detection technique, where both 1064 nm beams were coupled onto the near-infrared (near-IR) high-speed photodiode (PD), resulting in a beat note signal readout down-converted into the radio-frequency (RF) domain. The RF mixer was used to shift the beat note in frequency accordingly to the frequency modulation (FM) demodulator range. The demodulator converts the beat note frequency changes into a proportional voltage signal. To provide better gas sensor properties, a typical wavelength modulation spectroscopy (WMS) technique was additionally used. The solid-state laser intra-cavity photothermal sensor (SLIPS) is a unique approach to gas spectroscopy, which provides tens of ppbv sensitivity, more than 5000 signal-to-noise (SNR) ratio, baseline-free measurements, miniature, versatile and non-complex sensor setup based on inexpensive DPSSL technology. The SLIPS has no limitation in terms of the excitation wavelength because only one near-IR detector for signal retrieval is needed.
Incremental Redundancy Low-Density Parity Check Codes for MIMO V-BLAST Systems (2006)

The throughput of an incremental redundancy hybrid forward error correction/automatic retransmission request (IR-hybridARQ) scheme strongly depends on the design of the error correction code. In this paper, we consider ensembles of rate-compatible LDPC codes using an intentional puncturing algorithm in a vertical bell lab layered space-time (V-BLAST) system. We also present an adaptive IR-hybridARQ scheme with a code selection algorithm for reducing the traffic of a feedback channel. With the proposed adaptive code selection algorithm, we can reduce the traffic of the feedback channel for NACK signaling greatly without any significant throughput loss.
Granular fermentation enables high rate caproic acid production from solid-free thin stillage (2019)

Disc shaped microbial aggregates enriched in Ruminococcaceae and lactic acid bacteria produced caproic acid from solid-free thin stillage.
A scaled 0.25- mu m bipolar technology using full e-beam lithography (1992)

The full leverage offered by electron-beam lithography has been exploited in a scaled 0.25- mu m double polysilicon bipolar technology. Devices and circuits were fabricated using e-beam lithography for all mask levels with level-to-level overlays tighter than 0.06 mu m. Ion implantation was used to form a sub-100-nm intrinsic base profile, and a novel in-situ doped polysilicon emitter process was used to minimize narrow emitter effects. Transistors with 0.25- mu m emitter width have current gains above 80 and cutoff frequencies as high as 40 GHz. A record ECL gate delay of 20.8 ps at 4.82 mW has been measured together with a minimum power-delay product of 47 fJ (42.1 ps at 1.12 mW). These results demonstrate the feasibility and resultant performance leverage of aggressive scaling of conventional bipolar technologies.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Syntheses and affinities of novel organometallic-labeled estradiol derivatives: a structure-affinity relationship (1992)

Two series of novel estradiol derivatives, including cationic species, labeled with organometallic fragments Cr(CO)3, Cp*Ru+, or Cp*Rh2+ [Cp* = eta 5-C5(CH3)5] either in the 17 alpha-position or on the A-ring were synthesized, and their relative binding affinities (RBA) for the estradiol receptor were determined. The Ru(II) and the Rh(III) cationic derivatives were obtained as stable salts with the following counter anions (BF4-, PF6-, CF3SO3-). The satisfactory RBA values obtained for most complexes belonging to the 17 alpha series confirm that this position tolerates the presence of bulky neutral species. For instance, complex 4, in which the organometallic fragment Cr(CO)3 was attached to the phenyl ring of the 17 alpha-phenylethynyl fragment, exhibited an RBA value of 24%, very similar to that of the uncomplexed estrogen derivative 3. Surprisingly, the analogous cationic species 6 had no affinity for the estradiol receptor. This unprecedented result shows that the hormone binding site of the estrogen receptor does not tolerate the presence of a positive charge in the 17 alpha-position of the steroid. On the other hand, the alpha-face of the A-ring of estradiol did tolerate positively charged organometallic fragments bearing bulky substituents although the RBA value tended to decrease with increasing charge. The counterion in these cationic derivatives also affected binding affinity. For instance, the Ru(II) species 7a containing an CF3SO3- ion exhibited a reasonable RBA value (5.8%) compared to analogous species 13 with a PF6- ion (RBA of only 0.1%). Moreover, the triflate counteranion preserved the phenolic form of the A-ring of the estrogen derivative whereas the PF6- derivative was unstable and rapidly converted into the dienonylic form in buffer. The compared RBAs of the neutral and cationic species illustrate the preferences of the receptor hormone binding site in accepting or rejecting species of hydrophobic or hydrophilic character.
Carrier concentration dependence of terahertz transmission on conducting ZnO films (2008)

With the dc reactive magnetron sputtering method, conducting ZnO thin films with different carrier concentrations on glass substrate were fabricated. The dielectric responses of the ZnO films are characterized with terahertz time-domain spectroscopy. Frequency-dependent conductivity, power absorption, and refractive index are obtained, and the experimental results can be well reproduced with the classic Drude model. Our results reveal that by adjusting the carrier concentration of the ZnO film, the conducting ZnO film can serve as broadband antireflection coatings for substrates and optics in the terahertz frequency range.
Classification of confidential documents by using adaptive neurofuzzy inference systems (2011)

Detecting the security level of a confidential document is a vital task for organizations to protect the confidential information encapsulated in. Diverse classification rules and techniques are being applied by human experts. Increasing number of confidential information in organizations are making difficult to classify all the documents carefully with human effort. A hybrid approach involving support vector classifier and adaptive neuro-fuzzy classifier is proposed in this study. Also states preprocessing tasks required for document classification with natural language processing. To represent term-document relations a recommended metric TF-IDF was chosen to construct a weight matrix. Agglutinative nature of Turkish documents is handled by Turkish stemming algorithms. At the end of the article some experimental results and success metrics are projected with accuracy rates.
Protective MCMV immunity by vaccination of the salivary gland <i>via</i> Wharton's duct: replication‐deficient recombinant adenovirus expressing individual MCMV genes elicits protection similar to that of MCMV (2014)

Salivary glands, a major component of the mucosal immune system, confer antigen-specific immunity to mucosally acquired pathogens. We investigated whether a physiological route of inoculation and a subunit vaccine approach elicited MCMV-specific and protective immunity. Mice were inoculated by retrograde perfusion of the submandibular salivary glands via Wharton's duct with tcMCMV or MCMV proteins focused to the salivary gland via replication-deficient adenovirus expressing individual MCMV genes (gB, gH, IE1; controls: saline and replication deficient adenovirus without MCMV inserts). Mice were evaluated for MCMV-specific antibodies, T-cell responses, germinal center formation, and protection against a lethal MCMV challenge. Retrograde perfusion with tcMCMV or adenovirus expressed MCMV proteins induced a 2- to 6-fold increase in systemic and mucosal MCMV-specific antibodies, a 3- to 6-fold increase in GC marker expression, and protection against a lethal systemic challenge, as evidenced by up to 80% increased survival, decreased splenic pathology, and decreased viral titers from 10(6) pfu to undetectable levels. Thus, a focused salivary gland immunization via a physiological route with a protein antigen induced systemic and mucosal protective immune responses. Therefore, salivary gland immunization can serve as an alternative mucosal route for administering vaccines, which is directly applicable for use in humans.
Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels (2010)

The Rho family of small guanosine triphosphatases (Rho GTPases: RhoA, Cdc42, and Rac1) regulates many aspects of cell behavior, including actin dynamics and cell migration. The generation of calcium ion (Ca(2+)) microdomains is critical in promoting cell migration because they control the localized activity of Rho GTPases. We identified receptor-activated TRPC5 and TRPC6 (transient receptor potential canonical type 5 and 6) channels as antagonistic regulators of actin remodeling and cell motility in fibroblasts and kidney podocytes. We show that TRPC5 is in a molecular complex with Rac1, whereas TRPC6 is in a molecular complex with RhoA. TRPC5-mediated Ca(2+) influx induces Rac1 activation, thereby promoting cell migration, whereas TRPC6-mediated Ca(2+) influx increases RhoA activity, thereby inhibiting cell migration. Our data unveil antagonistic Ca(2+) influx pathways as a conserved signaling mechanism for the integrated regulation of cell migration.
Antitumor Activity of the Novel Human Cytokine AIMP1 in an in vivo Tumor Model (2006)

Although AIMP1 (previously known as p43) is one of three auxiliary proteins bound to a macromolecular aminoacyl tRNA complex, it is also secreted as a cytokine controlling both angiogenesis and immune responses. Here we show that systemically administered purified recombinant human AIMP1 had anti-tumor activity in mouse xenograft models. In Meth A-bearing Balb/c mice, tumor volume increased about 28 fold in the vehicle treatment group, while an increase of about 16.7 fold was observed in the AIMP1-treated group. We also evaluated the anti-tumor activity of AIMP1 in combination with a sub-clinical dose of the cytotoxic anti-tumor drug, paclitaxel. The growth of NUGC-3 human stomach cancer cells was suppressed by 84% and 94% by the combinations of 5 mg/kg paclitaxel + 25 mg/kg AIMP1 (p = 0.03), and 5 mg/kg paclitaxel + 50 mg/kg AIMP1 (p = 0.02), respectively, while 5 mg/kg paclitaxel alone suppressed growth by only 54% (p = 0.02). A similar cooperative effect of AIMP1 and paclitaxel was observed in a lung cancer xenograft model. These results suggest that AIMP1 may be useful as a novel anti-tumor agent.
Simulation exploration through immersive parallel planes (2016)

We present a visualization-driven simulation system that tightly couples systems dynamics simulations with an immersive virtual environment to allow analysts to rapidly develop and test hypotheses in a high-dimensional parameter space. To accomplish this, we generalize the two-dimensional parallel-coordinates statistical graphic as an immersive "parallel-planes" visualization for multivariate time series emitted by simulations running in parallel with the visualization. In contrast to traditional parallel coordinate's mapping the multivariate dimensions onto coordinate axes represented by a series of parallel lines, we map pairs of the multivariate dimensions onto a series of parallel rectangles. As in the case of parallel coordinates, each individual observation in the dataset is mapped to a polyline whose vertices coincide with its coordinate values. Regions of the rectangles can be "brushed" to highlight and select observations of interest: a "slider" control allows the user to filter the observations by their time coordinate. In an immersive virtual environment, users interact with the parallel planes using a joystick that can select regions on the planes, manipulate selection, and filter time. The brushing and selection actions are used to both explore existing data as well as to launch additional simulations corresponding to the visually selected portions of the input parameter space. As soon as the new simulations complete, their resulting observations are displayed in the virtual environment. This tight feedback loop between simulation and immersive analytics accelerates users' realization of insights about the simulation and its output.
Proteomic analysis of palmitoylated platelet proteins (2011)

Protein palmitoylation is a dynamic process that regulates membrane targeting of proteins and protein-protein interactions. We have previously demonstrated a critical role for protein palmitoylation in platelet activation and have identified palmitoylation machinery in platelets. Using a novel proteomic approach, Palmitoyl Protein Identification and Site Characterization, we have begun to characterize the human platelet palmitoylome. Palmitoylated proteins were enriched from membranes isolated from resting platelets using acyl-biotinyl exchange chemistry, followed by identification using liquid chromatography-tandem mass spectrometry. This global analysis identified > 1300 proteins, of which 215 met criteria for significance and represent the platelet palmitoylome. This collection includes 51 known palmitoylated proteins, 61 putative palmitoylated proteins identified in other palmitoylation-specific proteomic studies, and 103 new putative palmitoylated proteins. Of these candidates, we chose to validate the palmitoylation of triggering receptors expressed on myeloid cell (TREM)-like transcript-1 (TLT-1) as its expression is restricted to platelets and megakaryocytes. We determined that TLT-1 is a palmitoylated protein using metabolic labeling with [³H]palmitate and identified the site of TLT-1 palmitoylation as cysteine 196. The discovery of new platelet palmitoyl protein candidates will provide a resource for subsequent investigations to validate the palmitoylation of these proteins and to determine the role palmitoylation plays in their function.
High-energy (59 pJ) and low-jitter (250 fs) picosecond pulses from gain-switching of a tapered-stripe laser diode via resonant driving (1996)

High-energy (59 pJ), low-jitter (250 fs), high-extinction ratio (800), and short (14.5 ps FWHM) pulses were generated by gain-switching of a tapered stripe gain-guided laser diode (LD) via resonant driving. These characteristics are attributed to a stable single-mode near-field pattern, a single-lobe far-field pattern, and multilongitudinal modes associated with the tapered stripe LD under high driving current pulses. These pulses from a comb generator were enhanced mainly from reflection at the LD-transmission line impedance mismatch; the line length was adjusted for resonance with the reflection from the step recovery diode, further increasing the driving current.