gebhart/patrepeval huggingface dataset:
Expression of <scp>CD</scp>25 independently predicts early treatment failure of acute myeloid leukaemia (<scp>AML</scp>) (2012)

Expression of CD25 independently predicts early treatment failure of acute myeloid leukaemia (AML) CD25+ CD34+ CD38 leukaemic cells have been shown to be chemotherapy-resistant and initiate acute myeloid leukaemia (AML) in xenograft models, suggesting a leukaemic stem cells (LSC) biology (Saito et al, 2010). High CD25 (also known as interleukin 2 receptor alpha, IL2RA) expression (>10%) at diagnosis in young (<60 years) AML patients in retrospective analysis correlated with a significantly shorter overall survival (OS, P = 00005) and relapse-free survival (RFS, P = 0005). CD25 expression was also associated with FLT3-internal tandem duplication (ITD) mutation, and double positive patients had the poorest OS and RFS (P = 0001 and P = 0003, respectively; Terwijn et al, 2009).
A Resolution Equation for Electrokinetic Chromatography Based on Electrophoretic Mobilities (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Resolution Equation for Electrokinetic Chromatography Based on Electrophoretic MobilitiesJeffrey R. Mazzeo, Michael E. Swartz, and Edward R. GroverCite this: Anal. Chem. 1995, 67, 17, 2966–2973Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://doi.org/10.1021/ac00113a035RIGHTS & PERMISSIONSArticle Views82Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (703 KB) Get e-Alerts Get e-Alerts
The Drought in the Sahel (1974)

(1974). The Drought in the Sahel. The Black Scholar: Vol. 5, The Sixth Pan-African Congress, pp. 37-42.
Efficient c-kit Receptor-Targeted Gene Transfer to Primary Human CD34-Selected Hematopoietic Stem Cells (2001)

We have previously reported effective gene transfer with a targeted molecular conjugate adenovirus vector through the c-kit receptor in hematopoietic progenitor cell lines. However, a c-kit-targeted recombinant retroviral vector failed to transduce cells, indicating the existence of significant differences for c-kit target gene transfer between these two viruses. Here we demonstrate that conjugation of an adenovirus to a c-kit-retargeted retrovirus vector enables retroviral transduction. This finding suggests the requirement of endosomalysis for successful c-kit-targeted gene transfer. Furthermore, we show efficient gene transfer to, and high transgene expression (66%) in, CD34-selected, c-kit(+) human peripheral blood stem cells using a c-kit-targeted adenovirus vector. These findings may have important implications for future vector development in c-kit-targeted stem cell gene transfer.
Convenient preparation of 2‐benzoxazolinones with 1,1‐carbonyldiimidazole (1982)

Abstract A convenient and general preparation of 2‐benzoxazolinones from 2‐aminophenols with 1,1‐carbonyldiimidazole is described. Included is a discussion of a much improved synthesis of the reproductive‐stimulant 6‐methoxy‐2‐benzoxazolinone ( 6‐MBOA ) that utilizes this procedure.
Oligomers of Hexa-<i>p</i><i>eri</i>-hexabenzocoronenes as “Super-oligophenylenes”:  Synthesis, Electronic Properties, and Self-assembly (2004)

Hexa-peri-hexabenzocoronene (HBC) is a remarkable polycyclic aromatic hydrocarbon and is often called "superbenzene" because of its similarity to benzene. In this article we present the facile synthesis of oligomers of HBC, up to trimers (3, 4, 5a-c) with different modes of connection. UV-vis and fluorescence spectroscopy studies reveal that the oligomers are electronically decoupled. This arises from the small atomic orbital coefficients of the bridge-head carbon atoms, the large torsion angle between the HBC units, and the large distance of interacting transition dipoles due to the size of the HBC chromophore. For comparison, a methylene-bridged HBC dimer 6, so-called "superfluorene", was prepared. The induced planarity improves pi-conjugation and suppresses the geometrical relaxation of the backbone upon electronic excitation, leading to a prominent 0-0 transition band in the fluorescence spectra. The self-assembly of the oligomers and of superfluorene 6 was studied by wide-angle X-ray diffraction (WAXD) in the bulk state, and ordered columnar stacking occurs in the HBC dimer 3, p-HBC trimer 4, and superfluorene 6. Measurements of shear-aligned samples show that, despite increasing aspects ratio by linear entrainment of disks, the anitropic element that is subject to alignment by shear is the supramolecular columns.
Validation of DNA probes for preimplantation genetic diagnosis (PGD) by fluorescencein situ hybridization (FISH) R1 (2006)

Our validation results show good individual performance of commercially available probes, and decreasing overall efficiency as the number of probes included in an assay increases.
Refactor, Reduce, Recycle: Restructuring the I/O Stack for the Future of Storage (2013)

Emerging nonvolatile storage technologies promise orders-of-magnitude bandwidth increases and latency reductions, but fully realizing their potential requires minimizing storage software overhead and rethinking the roles of hardware and software in storage systems. The Web extra at http://youtu.be/pAALQ6k-CbE is an audio interview in which guest editor Simon S.Y. Shim interviews Steven Swanson about emerging nonvolatile storage technologies.
Quantum confinement of magnetic-dipolar oscillations in ferrite discs (2005)

Because of confinement phenomena, semiconductor quantum dots show typical atomic properties such as discrete energy levels and shell structures. The energy eigenstates are described based on the Schrodinger-like equation for the electronic envelope wavefunctions. From the point of view of fundamental studies, the reduction of dimensionality in microwave ferrites brings into play new effects, which should be described based on the quantized picture and demonstrate, as a fact, the properties of artificial atomic structures. The intermediate position of magnetic-dipolar (or magnetostatic) oscillations in ferrite samples between 'pure' electromagnetic and spin-wave (exchange-interaction) processes reveals the very special behaviour of geometrical effects. In view of recent studies on the local-field effects for subwavelength systems, some aspects of magnetic-dipolar oscillations in a normally magnetized ferrite disc should be re-considered based on macroscopically quantized methods. The purpose of this paper is to develop macroscopically quantized phenomenological models for magnetostatic-wave ferrite discs based on the Schrodinger-like equation.
A Simple and Convenient Synthesis of β-Aspartates and γ-Glutamates (1987)

A simple and convenient, high yield synthesis of ω-esters of aspartic as well as glutamic acid has been developed, using tetrafluoroboric acid as catalyst. 13C-NMR data of the products are given.
Ion-Selective Electrodes Based on Two Competitive Ionophores for Determining Effective Stability Constants of Ion−Carrier Complexes in Solvent Polymeric Membranes (1998)

A new potentiometric method to determine effective complex formation constants in organic membrane phases is reported in detail. It demands measurements with two different membranes, one containing a highly selective reference ionophore (in this case for H+) and anionic sites and another containing the same components and additionally the lipophilic ionophore to be characterized. The response characteristics of both electrodes can be compared and related to the effective complex formation constant of the ion carrier in the membrane. Potentiometric experiments with membranes containing a series of highly selective H+-ionophores confirm that alkali metal ions are not complexed by these ionophores. The ionophores valinomycin, BME-44, ETH 2120, tert-butylcalix[4]arene tetraethyl ester, and ETH 1810 are characterized using this potentiometric technique with potassium, sodium, and lithium ions in the sample. The complex formation constants are generally large and correspond very well to data obtained with a previously established optical method.
Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. (1994)

Active uptake of bile acids from the lumen of the small intestine is mediated by an ileal Na(+)-dependent bile acid transport system. To identify components of this transport system, an expression cloning strategy was employed to isolate a hamster ileal cDNA that exhibits bile acid transport activity. By Northern blot analysis, mRNA for the cloned transporter was readily detected in ileum and kidney but was absent from liver and proximal small intestine. The transporter cDNA encoded a 348-amino acid protein with seven potential transmembrane domains and three possible N-linked glycosylation sites. The amino acid sequence was 35% identical and 63% similar to the rat liver Na+/bile acid cotransporter. After transfection into COS cells, the hamster cDNA transported taurocholate in a strict Na(+)-dependent fashion with an apparent Km of 33 microM. This taurocholate transport was inhibited by various bile acids but not by taurine or other organic anions. The Na+ dependence, saturability, and bile acid specificity of transport as well as the tissue specificity of mRNA expression strongly argue that the transporter cDNA characterized in this study is the Na+/bile acid cotransporter described previously in ileum.
Time delay deep neural network-based universal background models for speaker recognition (2015)

Recently, deep neural networks (DNN) have been incorporated into i-vector-based speaker recognition systems, where they have significantly improved state-of-the-art performance. In these systems, a DNN is used to collect sufficient statistics for i-vector extraction. In this study, the DNN is a recently developed time delay deep neural network (TDNN) that has achieved promising results in LVCSR tasks. We believe that the TDNN-based system achieves the best reported results on SRE10 and it obtains a 50% relative improvement over our GMM baseline in terms of equal error rate (EER). For some applications, the computational cost of a DNN is high. Therefore, we also investigate a lightweight alternative in which a supervised GMM is derived from the TDNN posteriors. This method maintains the speed of the traditional unsupervised-GMM, but achieves a 20% relative improvement in EER.
The mechanism of body temperature changes induced by intraventricular injections of adrenaline, noradrenaline and 5‐hydroxytryptamine in the ox (<i>bos taurus</i>) (1967)

1. Adrenaline, noradrenaline and 5-hydroxytryptamine (5-HT) were injected into the lateral ventricle of the ox. The effect of these drugs was measured on the respiratory rate, tidal volume, heat production, skin temperature of the ear, evaporative loss from the skin and the rectal temperature at 20 and 10 degrees C ambient temperature.2. Neither adrenaline (3 mg) nor noradrenaline (3 mg) had any effect on the temperature regulating mechanisms of the ox, except to produce vasoconstriction if vasodilatation was already present due to high ambient temperature or previous injection of 5-HT.3. Injection of 5-HT (5 mg) caused a rise in respiratory rate, a fall in tidal volume and heat production, elevation of ear skin temperature and skin evaporative loss and a decrease in rectal temperature. Sedation of the animals occurred.4. In its reaction to these monoamines the ox is similar to the goat, sheep and rabbit, but is unlike the cat and dog.5. It was concluded that neither adrenaline nor noradrenaline has a role in the central control of temperature regulation in the ox, but that 5-HT may be involved in the control of heat dissipation mechanisms.
Multifrequency operation technique for aperture coupled microstrip antennas (2002)

A multiple frequency operation technique is proposed for a microstrip antenna, in which the structure is fed by a microstrip line through an aperture coupling. The technique is general and can also be applied to microstrip antennas with other feed types. It allows the antenna to operate at several discrete frequencies over a wide frequency band.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pharmacokinetics of Valproate After Multiple‐Dose Oral and Intravenous Infusion Administration: Gastrointestinal‐Related Diurnal Variation (1994)

A randomized, crossover study was conducted in healthy male volunteers to assess the diurnal variation in the steady-state pharmacokinetics of valproate after multiple 250-mg oral and intravenous infusion doses after an intravenous 750-mg loading dose. Multiple blood samples were collected throughout each 168-hour study period, and plasma valproate concentrations were quantitated using a gas chromatographic technique. Within-regimen comparisons indicated statistically significant differences for mean steady-state peak (Cmax) and trough (Cmin) plasma concentrations and area under the plasma concentration-versus-time curve (AUC) between the second and third doses on day 4 after oral dosing, indicating a diurnal variation in the rate of valproate absorption from the delayed-release tablet preparation. Between-regimen steady-state comparisons of pharmacokinetic parameters revealed some significant differences in mean time to Cmax (Tmax), Cmax, Cmin, AUC, and total body clearance for respective day-4 dosing intervals, but not for the entire day 4, except for Cmin and Tmax. Mean elimination rate constant and half-life did not significantly differ between the regimens. The regimens were bio-equivalent at steady state, as assessed by 90% confidence intervals (two one-sided test procedures) for Cmax, Cmin, and AUC, with similarity in degrees of fluctuation ((Cmax-Cmin)/Caverage). Despite the presence of diurnal variation in valproate absorption after oral dose administration, the steady-state plasma concentration-versus-time profile was well maintained by both regimens within the accepted therapeutic range of 50 to 100 micrograms/mL.
Peripheral B lymphocyte <i>β</i>1,3‐galactosyltransferase and chaperone expression in immunoglobulin A nephropathy (2005)

These data suggested that the aberrant IgA O-glycosylation in IgAN was resulted from a downregulation of beta1,3GT chaperone (Cosmc) expression in B lymphocyte, which is closely associated with clinical characteristics of the disease. This downregulation might be one of the fundamental pathogenic abnormalities in IgAN.
System Measurement and Identification Using Pseudorandom Filtered Noise and Music Sequences (2005)

System measurement using pseudorandom filtered noise and music sequences is investigated. A single-pass technique is used to evaluate simultaneously the transfer function and the spectral-domain signal-to-distortion ratio that is applicable to amplifiers, signal processors, digital-to-analog converters, loudspeakers, and perceptual coders. The technique is extended to include a simplified Volterra model expressed as a power series and linear filter bank where for compliant systems, nonlinear distortion can be estimated for an arbitrary excitation without a need for remeasurement.
A Mobile Phone Based Intelligent Telemonitoring Platform (2006)

In this paper, we propose a generic smart telemonitoring platform in which the computation power of the mobile phone is highly utilized. In this approach, compression of ECG is done in real-time by the mobile phone for the very first time. The fast and effective compression scheme, designed for the proposed telemonitoring system, outperforms most of the real-time lossless ECG compression algorithms. This mobile phone based computation platform is a promising solution for privacy issues in telemonitoring through encryptions. Moreover, the mobile phones used in this platform performs preliminary detection of abnormal biosignal in realtime. Apart from the usage of mobile phones, this platform supports background biosignal abnormality surveillance using data mining agent.
Atrial Fibrillation Detection Using an iPhone 4S (2012)

Atrial fibrillation (AF) affects three to five million Americans and is associated with significant morbidity and mortality. Existing methods to diagnose this paroxysmal arrhythmia are cumbersome and/or expensive. We hypothesized that an iPhone 4S can be used to detect AF based on its ability to record a pulsatile photoplethysmogram signal from a fingertip using the built-in camera lens. To investigate the capability of the iPhone 4S for AF detection, we first used two databases, the MIT-BIH AF and normal sinus rhythm (NSR) to derive discriminatory threshold values between two rhythms. Both databases include RR time series originating from 250 Hz sampled ECG recordings. We rescaled the RR time series to 30 Hz so that the RR time series resolution is 1/30 (s) which is equivalent to the resolution from an iPhone 4S. We investigated three statistical methods consisting of the root mean square of successive differences (RMSSD), the Shannon entropy (ShE) and the sample entropy (SampE), which have been proved to be useful tools for AF assessment. Using 64-beat segments from the MIT-BIH databases, we found the beat-to-beat accuracy value of 0.9405, 0.9300, and 0.9614 for RMSSD, ShE, and SampE, respectively. Using an iPhone 4S, we collected 2-min pulsatile time series from 25 prospectively recruited subjects with AF pre- and postelectrical cardioversion. Using derived threshold values of RMSSD, ShE and SampE from the MIT-BIH databases, we found the beat-to-beat accuracy of 0.9844, 0.8494, and 0.9522, respectively. It should be recognized that for clinical applications, the most relevant objective is to detect the presence of AF in the data. Using this criterion, we achieved an accuracy of 100% for both the MIT-BIH AF and iPhone 4S databases.
How speedy is SPDY (2014)

SPDY is increasingly being used as an enhancement to HTTP/1.1. To understand its impact on performance, we conduct a systematic study of Web page load time (PLT) under SPDY and compare it to HTTP. To identify the factors that affect PLT, we proceed from simple, synthetic pages to complete page loads based on the top 200 Alexa sites. We find that SPDY provides a significant improvement over HTTP when we ignore dependencies in the page load process and the effects of browser computation. Most SPDY benefits stem from the use of a single TCP connection, but the same feature is also detrimental under high packet loss. Unfortunately, the benefits can be easily overwhelmed by dependencies and computation, reducing the improvements with SPDY to 7% for our lower bandwidth and higher RTT scenarios. We also find that request prioritization is of little help, while server push has good potential; we present a push policy based on dependencies that gives comparable performance to mod_spdy while sending much less data.
Sensitive and selective colorimetric detection of Cu<sup>2+</sup>in aqueous medium via aggregation of thiomalic acid functionalized Ag nanoparticles (2014)

A simple and effective colorimetric method for determination of Cu(2+) in real samples was developed. In this method, thiomalic acid functionalized silver nanoparticles (TMA-AgNPs) were prepared and changes in solution color, induced by the aggregation of TMA-AgNPs in the presence of Cu(2+), were employed for quantitative analysis. The surface plasmon resonance (SPR) band of our synthesized TMA-AgNPs was located at 392 nm and shifted to a longer wavelength after aggregation due to the interactions between carboxylate and Cu(2+). A band intensity ratio of A455/(A392-A455) was constructed and used to correlate with the concentration of Cu(2+). A linear relationship was found with a linear response up to 50 nM of Cu(2+). Due to the formation of a stable carboxylate Cu(2+) complex, highly sensitive detection of Cu(2+) was achieved with the estimated detection limit approaching 1 nM. Moreover, the formation of the stable complex leads to high selectivity in the detection of Cu(2+), which was verified by examination of 12 other metal ions. In the detection of Cu(2+) in real samples, results indicated that our proposed method is simple, sensitive and selective for application in such measurements.
Wafer-fused optoelectronics for switching (1998)

Wafer fusion technique for realization of compact waveguide switches and three-dimensional (3-D) photonic integrated circuits is investigated theoretically and experimentally. Calculations based on beam propagation method show that very short vertical directional couplers with coupling lengths from 40 to 220 /spl mu/m and high extinction ratios from 20 to 32 dB can be realized. These extinction ratios can be further improved using a slight asymmetry in waveguide structure. The optical loss at the fused interface is investigated. Comparison of the transmission loss in InGaAsP-based ridge-loaded waveguide structures with and without a fused layer near the core region, reveals an excess loss of 1.1 dB/cm at 1.55 /spl mu/m wavelength. Fused straight vertical directional couplers have been fabricated and characterized. Waveguides separated by 0.6 /spl mu/m gap layer exhibit a coupling length of 62 /spl mu/m and a switching voltage of about 2.2 V. Implications for GaAs-based fused couplers for 850 nm applications will also be discussed.
Power Transmission by Optical Fibers for Component Inherent Communication (2010)

The use of optical fibers for power transmission has been investigated intensely. An optically powered device combined with optical data transfer offers several advantages compared to systems using electrical connections. Optical transmission systems consist of a light source, a transmission medium and a light receiver. The overall system performance depends on the efficiency of opto-electronic converter devices, temperature and illumination dependent losses, attenuation of the transmission medium and coupling between transmitter and fiber. This paper will summarize the state of the art for optically powered systems and will discuss reasons for negative influences on efficiency. Furthermore, an outlook on power transmission by the use of a new technology for creating polymer optical fibers (POF) via micro dispensing will be given. This technology is capable to decrease coupling losses by direct contacting of opto-electronic devices.