gebhart/patrepeval huggingface dataset:
Effect of Constraint-Induced Movement Therapy on Upper Extremity Function 3 to 9 Months After Stroke (2006)

Among patients who had a stroke within the previous 3 to 9 months, CIMT produced statistically significant and clinically relevant improvements in arm motor function that persisted for at least 1 year. Trial Registration clinicaltrials.gov Identifier: NCT00057018.
<scp>Sna</scp>3 Is an <scp>Rsp</scp>5 Adaptor Protein that Relies on Ubiquitination for Its <scp>MVB</scp> Sorting (2011)

The process in which ubiquitin (Ub) conjugation is required for trafficking of integral membrane proteins into multivesicular bodies (MVBs) and eventual degradation in the lumen of lysosomes/vacuoles is well defined. However, Ub-independent pathways into MVBs are less understood. To better understand this process, we have further characterized the membrane protein Sna3, the prototypical Ub-independent cargo protein sorted through the MVB pathway in yeast. We show that Sna3 trafficking to the vacuole is critically dependent on Rsp5 ligase activity and ubiquitination. We find Sna3 undergoes Ub-dependent MVB sorting by either becoming ubiquitinated itself or associating with other ubiquitinated membrane protein substrates. In addition, our functional studies support a role for Sna3 as an adaptor protein that recruits Rsp5 to cargo such as the methionine transporter Mup1, resulting in efficient Mup1 delivery to the vacuole.
<i>Pantoea agglomerans</i>Strain EH318 Produces Two Antibiotics That Inhibit<i>Erwinia amylovora</i>In Vitro (2001)

Pantoea agglomerans (synonym: Erwinia herbicola) strain Eh318 produces through antibiosis a complex zone of inhibited growth in an overlay seeded with Erwinia amylovora, the causal agent of fire blight. This zone is caused by two antibiotics, named pantocin A and B. Using a genomic library of Eh318, two cosmids, pCPP702 and pCPP704, were identified that conferred on Escherichia coli the ability to inhibit growth of E. amylovora. The two cosmids conferred different antibiotic activities on E. coli DH5alpha and had distinct restriction enzyme profiles. A smaller, antibiotic-conferring DNA segment from each cosmid was cloned. Each subclone was characterized and mutagenized with transposons to generate clones that were deficient in conferring pantocin A and B production, respectively. Mutated subclones were introduced into Eh318 to create three antibiotic-defective marker exchange mutants: strain Eh421 (pantocin A deficient); strain Eh439 (pantocin B deficient), and Eh440 (deficient in both pantocins). Cross-hybridization results, restriction maps, and spectrum-of-activity data using the subclones and marker exchange mutants, supported the presence of two distinct antibiotics, pantocin A and pantocin B, whose biosynthetic genes were present in pCPP702 and pCPP704, respectively. The structure of pantocin A is unknown, whereas that of pantocin B has been determined as (R)-N-[((S)-2-amino-propanoylamino)-methyl]-2-methanesulfonyl-s uccina mic acid. The two pantocins mainly affect other enteric bacteria, based on limited testing.
Energy Level Based Transmission Power Control Scheme for Energy Harvesting WSNs (2011)

The purpose of this paper is to represent a wind powered wireless sensor network system and introduce a novel transmission power control scheme based on remaining energy level and energy harvesting status to extend the lifetime of WSNs. Energy constraint has always been one of the most significant problems of wireless sensor networks along with the development. Many methods have been introduced to solve this problem, basically in two aspects: energy management and energy harvesting. In this paper, a sensor network system has been developed which uses wind power as energy harvesting resource and ultra-capacitor as energy storage. By analyzing the power recharging, leakage and energy consumption rate, a novel Energy Level based Transmission Power Control scheme (EL-TPC) is produced. In EL-TPC scheme, the transmission power is classified into three levels which correspond to specified communication requirements. By adapting the nodes' operation pattern, hierarchical network architecture can be formed, which prioritizes the use of high energy level, fast charging and leaking nodes to save the energy of uncharged nodes. The scheme is implemented in a Building Surface mounted, Wind Power collected Wireless Sensor Network system called BSWPWSN, which aims to monitoring the usage pattern of air conditioners and the outdoor temperature. The results show that EL-TPC scheme can significantly balance the energy consumption in different nodes and extend the entire network lifetime. The overall energy level of the network keeps a dynamic balance during the experiment, which indicates that the network will not lose effect due to energy constraint.
Three-dimensional shapes and distribution of FePd nanoparticles observed by electron tomography using high-angle annular dark-field scanning transmission electron microscopy (2010)

We have studied three-dimensional shapes and distribution of FePd nanoparticles, prepared by electron beam deposition and postdeposition annealing, by means of single-axis tilt tomography using atomic number contrasts obtained by high-angle annular dark-field scanning transmission electron microscopy. Particle size, shape, and locations were reconstructed by weighted backprojection (WBP), as well as by simultaneous iterative reconstruction technique (SIRT). We have also estimated the particle size by simple extrapolation of tilt-series original data sets, which proved to be quite powerful. The results of the two algorithms for reconstruction have been compared quantitatively with those obtained by the extrapolation method and those independently reported by electron holography. It was found that the reconstructed intensity map by WBP contains a small amount of dotlike artifacts, which do not exist in the results by SIRT, and that the particle surface obtained by WBP is rougher than that by SIRT. We demonstrate, on the other hand, that WBP yields a better estimation of the particle size in the z direction than SIRT does, most likely due to the presence of a “missing wedge” in the original data set.
Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium (2000)

Although previous studies demonstrated carbonic anhydrase (CA) activity in the human endometrium, the CA isozyme(s) responsible for this activity has not been established. In this report, we provide the first evidence that the CA isozyme XII, a recently identified transmembrane isozyme that is expressed in normal kidney and greatly overexpressed in some renal cancers, is present in endometrium. We show by immunohistochemistry that CA XII is expressed in the basolateral plasma membrane of epithelial cells of normal human endometrium. Expression of CA XII in uterus was confirmed by Northern blotting. Detergent-solubilized CA XII was isolated from human endometrium by inhibitor affinity chromatography and characterized by isoelectric focusing and Western blot as a polypeptide with a pI of 6.3. The high expression of CA XII in the endometrial epithelium suggests that it may be functionally linked to the pH-dependent events in spermatozoa that precede fertilization. Its basolateral location and extracellular active site could also allow it to influence the morphological changes in endometrium that occur during the menstrual cycle.
Salmonella as Live Trojan Horse for Vaccine Development and Cancer Gene Therapy (2010)

The design of efficient vectors for vaccine development and cancer gene therapy is an area of intensive research. Bacteria-based vectors are being investigated as optimal vehicles for antigen and therapeutic gene delivery to immune and tumour cells. Attenuated Salmonella strains have shown great potential as live vectors with broad applications in human and veterinary medicine. An impressively high, and still growing, number of reports published over the last two decades have demonstrated the effectiveness in animal models of Salmonella-based therapies for the prevention and treatment of infectious and non-infectious diseases, as well as cancer. Further, the recent dramatic expansion in knowledge of genetics, biology and pathogenesis of the bacteria allows more rational design of Salmonella constructs tailored for specific applications. However, only few clinical trials have been conducted so far, and although they have conclusively demonstrated the safety of this system, the results on immunogenicity are less than optimal. Thus, more research particularly in target species is required to bring this system closer to human and veterinary use. In this review we first describe some particularities of the bacteria and its relationship with the host that could be on the basis of its success as vector, and then summarize the different strategies used so far to develop Salmonella-based vaccines for infectious diseases as well as for non-traditional indications such as prion and Alzheimer disease vaccination. Finally, we review the many different approaches that employ Salmonella for the design of new therapies for cancer.
High Extinction Polarimeter for the Precision Measurement of the In-Plane Optical Anisotropy of Molecular Monolayers (2010)

A polarimeter using selected Glan-Thompson polarizers, a spatially filtered probe laser beam, precision polarizer orientation, and spatially filtered output coupling into an optical fiber achieves a static extinction ratio between crossed and parallel polarizer and analyzer orientations of I(perpendicular)/I(parallel) approximately = 2 x 10(-10). This instrument allows the detection of retardance as small as 0.0015 nm to better than 1%, enabling the first detailed study of the in-plane birefringence of molecular monolayers. We demonstrate the performance of the polarimeter with measurements of the photoinduced birefringence of azobenzene-based monolayers self-assembled on glass.
Circular microstrip patch antenna strain sensor for wireless structural health monitoring (2010)

A major rise in the prevalence and influence of colorectal cancer (CRC) leads to substantially increasing healthcare costs and even death. It is widely accepted that early detection and removal of colonic polyps can prevent CRC. Detection of colonic polyps in colonoscopy videos is problematic because of complex environment of colon and various shapes of polyps. Currently, researchers indicate feasibility of Convolutional Neural Network (CNN)-based detection of polyps but better feature extractors are needed to improve detection performance. In this paper, we investigated the potential of the single shot detector (SSD) framework for detecting polyps in colonoscopy videos. SSD is a one-stage method, which uses a feed-forward CNN to produce a collection of fixed-size bounding boxes for each object from different feature maps. Three different feature extractors, including ResNet50, VGG16, and InceptionV3 were assessed. Multi-scale feature maps integrated into SSD were designed for ResNet50 and InceptionV3, respectively. We validated this method on the 2015 MICCAI polyp detection challenge datasets, compared it with teams attended the challenge, YOLOV3 and two-stage method, Faster-RCNN. Our results demonstrated that the proposed method surpassed all the teams in MICCAI challenge and YOLOV3 and was comparable with two-stage method. Especially in detection speed aspect, our proposed method outperformed all the methods, met real-time application requirement. Meanwhile, we also indicated that among all the feature extractors, InceptionV3 obtained the best result of precision and recall. In conclusion, SSD- based method achieved excellent detection performance in polyp detection and can potentially improve diagnostic accuracy and efficiency.
Review: <i>A History of Historical Writing</i>, by Harry Elmer Barnes (1937)

Book Review| December 01 1937 Review: A History of Historical Writing, by Harry Elmer Barnes A History of Historical WritingHarry Elmer Barnes J. W. C. J. W. C. Search for other works by this author on: This Site PubMed Google Scholar Pacific Historical Review (1937) 6 (4): 388–389. https://doi.org/10.2307/3633895 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J. W. C.; Review: A History of Historical Writing, by Harry Elmer Barnes. Pacific Historical Review 1 December 1937; 6 (4): 388–389. doi: https://doi.org/10.2307/3633895 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPacific Historical Review Search This content is only available via PDF. Copyright 1937 The Arthur H. Clark Company Article PDF first page preview Close Modal You do not currently have access to this content.
NetTurnP – Neural Network Prediction of Beta-turns by Use of Evolutionary Information and Predicted Protein Sequence Features (2010)

The NetTurnP method has been implemented as a webserver, which is freely available at http://www.cbs.dtu.dk/services/NetTurnP/. NetTurnP is the only available webserver that allows submission of multiple sequences.
THE SENSORY AND MOTOR ROLE OF IMPULSES TRAVELLING IN THE DORSAL COLUMNS TOWARDS CEREBRAL CORTEX (1970)

Journal Article THE SENSORY AND MOTOR ROLE OF IMPULSES TRAVELLING IN THE DORSAL COLUMNS TOWARDS CEREBRAL CORTEX Get access PATRICK D. WALL PATRICK D. WALL From The M.R.C. Cerebral Functions Research Group, Department of Anatomy, University CollegeLondon, W.C.1 Search for other works by this author on: Oxford Academic PubMed Google Scholar Brain, Volume 93, Issue 3, 1970, Pages 505–524, https://doi.org/10.1093/brain/93.3.505 Published: 01 July 1970 Article history Received: 19 November 1969 Published: 01 July 1970
Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study (2015)

MTD was defined as 10.2 mg/m(2), with a calculated median plasma half-life of 18.25 h. The maximum plasma concentration of selenium from a single dose of selenite increased in a nonlinear pattern. The most common adverse events were fatigue, nausea, and cramps in fingers and legs. DLTs were acute, of short duration and reversible. Biomarkers for organ functions indicated no major systemic toxicity. In conclusion, sodium selenite is safe and tolerable when administered up to 10.2 mg/m(2) under current protocol. Further development of the study is underway to determine if prolonged infusions might be a more effective treatment strategy.
Therapeutic Effects of Bacteriophage Cpl-1 Lysin against <i>Streptococcus pneumoniae</i> Endocarditis in Rats (2005)

Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.
Ionic Liquids: Improved Syntheses and New Products (2003)

We report here the improved syntheses of 1-alkyl-3-methylimidazolium ionic liquids. Microwave irradiation drastically reduces the preparation time of 1-alkyl-3-methylimidazolium and N-alkylpyridinium halide salts and, in addition, three halide-free routes to ionic liquids have been developed. New, chiral, imidazolium-based ionic liquids were prepared using both conventional and halide-free procedures. Chirality was introduced in the new compounds at either the cation or the anion, or both.
Rapid Peptide Synthesis in Liquid Phase. Preparation of Angiotensin II and Delta-sleep-inducing Peptide by the “Hold-in-Solution” Method (1982)

Abstract A new technique for rapid peptide synthesis has been demonstrated by the preparation of a protected angiotensin II, Z–Asp(OBzl)–Arg(NO2)–Val–Tyr(Bzl)–Ile–His(Bzl)–Pro–Phe–OBzl (1), and a protected delta-sleep-inducing peptide, Z–Trp–Ala–Gly–Gly–Asp(OBzl)–Ala–Ser(Bzl)–Gly–Glu(OBzl)–OBzl (2). Elongation of the peptide chain was carried out in 1,2-dichloroethane by repeating the following series of operations: acylation of a benzyl ester of amino acid or peptide with Boc-amino acid by 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole; washing of the organic layer; acidolysis of the α-amino protector; neutralization; and washing. Throughout the synthesis, the growing pep tides were held in the organic layer without being isolated. The protected peptides, 1 and 2, were obtained in overall yields of 78% and 53% based on their C-terminal amino acid esters, and were then hydrogenated to give angiotensin II and delta-sleep-inducing peptide, respectively, thus demonstrating the usefulness of this method for rapid peptide synthesis.
An experimental investigation of fracture by cavitation of model elastomeric networks (2010)

Abstract A new methodology to investigate the failure of elastomers in a confined geometry has been developed and applied to model end‐linked polyurethane elastomers. The experimental in situ observations show that the elastomers fail by the growth of a single cavity nucleated in the region of maximum hydrostatic stress. Tests carried out at different temperatures for the same elastomer show that the critical stress at which this crack grows is not proportional to the Young's modulus E but depends mainly on the ratio between the mode I fracture energy G IC and E . A reasonable fit of the data can be obtained with a model of cavity expansion by irreversible fracture calculating the energy release rate by finite elements with a strain hardening constitutive equation. Comparison between different elastomers shows that the material containing both entanglements and crosslinks is both tougher in mode I and more resistant to cavitation relative to its elastic modulus. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48:1409–1422, 2010
A 24‐week, double‐blind, placebo‐controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease—pilot study (2002)

Donepezil Hydrochloride administered once a day appears to be generally well tolerated and safe in DS adults who have AD. There is some possible efficacy in the treatment of symptoms of mild to moderate Alzheimer's disease in this population, although the sample size of this study was too small for statistical significance. It is recommended that donepezil, with the appropriate precautions, should be considered for the treatment of AD in adults with DS as deemed by a specialist.
Velocity‐saturation relation for partially saturated rocks with fractal pore‐fluid distribution (2007)

Attenuation‐ and velocity‐saturation relations of P‐waves are developed for partially saturated porous media in which the fluid patches form random fractals. Depending on fractal measures the velocity‐saturation relation can vary between the exact Gassmann‐Wood and Gassmann‐Hill bounds. The results indicate that the fractal character of the pore fluid distribution affects significantly seismic velocities and attenuation.
Titanium (III) Reduction of Sulfoxides (1973)

Abstract Titanium (III) chloride is a mild and effective reagent for the generation of carbonyl compounds from oximes1 and nitroalkanes2. Imines have been posutlated as the intermediates which undergo in situ hydrolysis to afford the final products.
Physiologic activity of some fungal estrogens produced by Fusarium. (1968)

Summary An estrogen (F-2) produced by Fusarium graminearum under natural conditions, causes marked uterotropic response in rats, mice, gilts, and guinea pigs and is suspected of contributing to problems of infertility in dairy cattle. Its range of biologic activity is quite broad. Besides its activity in animals, it also has a stimulating effect in bud initiation of tobacco pith callus tissue in culture and affects the sexual cycle of various fungi. Out of the study of the biosynthesis of F-2, four other estrogenic metabolites produced by F. graminearum have been discovered.
Synthesis of furano steroids and analogs via Claisen rearrangement (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of furano steroids and analogs via Claisen rearrangementI. R. Trehan, Harvinder P. Singh, D. V. L. Rewal, and Ajay K. BoseCite this: J. Org. Chem. 1974, 39, 17, 2656–2657Publication Date (Print):August 1, 1974Publication History Published online1 May 2002Published inissue 1 August 1974https://pubs.acs.org/doi/10.1021/jo00931a057https://doi.org/10.1021/jo00931a057research-articleACS PublicationsRequest reuse permissionsArticle Views42Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Highly sensitive detection of microbending in single-mode fibers and its applications (2017)

This paper investigates the applicability of 1-μm-band mode-detection optical time domain reflectometry (OTDR), which detects microbending in single-mode fibers with high sensitivity by conducting measurements in the two-mode region of the fibers under test and observing the second-order mode of the backscattered light. To demonstrate its feasibility, we evaluate microbending losses as determined by the technique, and comparisons are made with conventional OTDR operating at the wavelength of 1650 nm. In addition, we discuss two potential applications of the technique. One is microbend sensing of fibers and cables for detecting microbending losses that are too small to be found with conventional OTDR. The other is health monitoring of installed fiber cables. This enables us to detect the growth in microbending losses at an earlier stage. Proof of concept is demonstrated experimentally.