gebhart/patrepeval huggingface dataset:
Performance of detect-on-track in a high shipping environment (2002)

A detect-on-track algorithm based on the Hough transform has been applied to acoustic broadband correlograms for passive detection and localization. When normalized by the number of points, the Hough transform computes the arithmetic-mean along a track. The process is referred to as an arithmetic-sum (AS) transform. Two nonlinear transforms have been proposed: the logarithmic-sum (LS) transform and the harmonic-sum (HS) transform. The LS-transform sums dBs while the HS-transform sums the reciprocal of the power along the track. In this study, the detect-on-track algorithm has been modified and applied to the narrowband beamformed output. Several different beamforming approaches including adaptive plane-wave beamforming and shaded plane-wave beamforming were considered. The detect-on-track performance is evaluated against a typical scenario in a high shipping noise environment using a dynamic simulation over a long time period.
NOVOBIOCIN. II. STRUCTURE OF NOVOBIOCIN (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNOVOBIOCIN. II. STRUCTURE OF NOVOBIOCINClifford H. Shunk, Charles H. Stammer, Edward A. Kaczka, Edward Walton, Claude F. Spencer, Andrew N. Wilson, John W. Richter, Frederick W. Holly, and Karl FolkersCite this: J. Am. Chem. Soc. 1956, 78, 8, 1770–1771Publication Date (Print):April 1, 1956Publication History Published online1 May 2002Published inissue 1 April 1956https://pubs.acs.org/doi/10.1021/ja01589a084https://doi.org/10.1021/ja01589a084research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug (2012)

By combining PharmDB, an integrated tripartite database, with Shared Neighborhood Scoring (SNS) algorithm, we developed a knowledge platform to rationally identify new indications for known FDA approved drugs, which can be customized to specific projects using manual curation. The data in PharmDB is open access and can be easily explored with phExplorer and accessed via BioMart web service (http://www.i-pharm.org/, http://biomart.i-pharm.org/).
An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models (2014)

While it is increasingly recognized that three-dimensional (3D) cell culture models recapitulate drug responses of human cancers with more fidelity than monolayer cultures, a lack of quantitative analysis methods limit their implementation for reliable and routine assessment of emerging therapies. Here, we introduce an approach based on computational analysis of fluorescence image data to provide high-content readouts of dose-dependent cytotoxicity, growth inhibition, treatment-induced architectural changes and size-dependent response in 3D tumour models. We demonstrate this approach in adherent 3D ovarian and pancreatic multiwell extracellular matrix tumour overlays subjected to a panel of clinically relevant cytotoxic modalities and appropriately designed controls for reliable quantification of fluorescence signal. This streamlined methodology reads out the high density of information embedded in 3D culture systems, while maintaining a level of speed and efficiency traditionally achieved with global colorimetric reporters in order to facilitate broader implementation of 3D tumour models in therapeutic screening.
QInfer: Statistical inference software for quantum applications (2017)

Characterizing quantum systems through experimental data is critical to applications as diverse as metrology and quantum computing. Analyzing this experimental data in a robust and reproducible manner is made challenging, however, by the lack of readily-available software for performing principled statistical analysis. We improve the robustness and reproducibility of characterization by introducing an open-source library, QInfer, to address this need. Our library makes it easy to analyze data from tomography, randomized benchmarking, and Hamiltonian learning experiments either in post-processing, or online as data is acquired. QInfer also provides functionality for predicting the performance of proposed experimental protocols from simulated runs. By delivering easy-to-use characterization tools based on principled statistical analysis, QInfer helps address many outstanding challenges facing quantum technology.
A procedure to calculate the in-situ contribution to body scattering caused by conformal cavity-backed apertures (2002)

This paper presents a theoretical procedure whereby a conformal aperture's in-situ contribution to the total radar cross section (RCS) of a body can be efficiently and accurately calculated. The result is equivalent to subtracting the RCS of the body with the aperture shorted from the RCS of the body with the aperture present. In RCS measurements, this technique is commonly referred to coherent fixture subtraction. The approach presented uses the electric current density at the aperture location on the body (computed with the aperture shorted) to derive new excitation and measurement vectors for the fields scattered by the conformal aperture. These surface currents may be obtained from a number of well-validated computer codes, such as JRMBOR CARLOS 3-D or PARAMOM. The electromagnetic characteristics of the cavity-backed aperture are rigorously modelled by an admittance matrix, which is calculated by a finite element method and assumes an infinite planar or singly curved installation environment. Fixture effects, such as surface wave and creeping wave excitation of the aperture, are also accurately accounted for in this procedure.
Long-term fluoride release from a glass ionomer cement, a compomer, and from experimental resin composites (2002)

The aqueous phase of glass ionomer cements enables fluoride ions to diffuse and to be released from the material. The matrix of resin composites is much less hydrophilic, and fluoride incorporated in the material is only released in small amounts. It was the purpose of the present work to study the influence of resin matrix formulation on the fluoride release from experimental, fluoride-containing resin composites. The resin composites were based on methacrylate monomers and the adduct of maleic anhydride and HEMA (2-hydroxyethyl methacrylate). The resin composites contained 1 w% or 5 w% of AlF3·3H2O. A glass ionomer cement and a compomer were used as controls. Five disks of each material were stored in distilled water at room temperature. By means of a fluoride sensitive electrode, the fluoride release from disk-shaped specimens was determined periodically over 3 years. The glass ionomer cement released the most fluoride (154 - 4 µg/cm2 after 1 year and 248 - 7 µg/cm2 after 3 years). The compomer released relatively little fluoride during the 1st year (30 - 1 µg/cm2), but after this time the rate of fluoride release became equal to that of the glass ionomer cement, resulting in a release of 122 - 8 µg/cm2 after 3 years. Regarding the resin composites, the fluoride release increased with the hydrophilicity and the acid character of the polymer matrix. The release, however, was significantly lower than that from the glass ionomer cement and the compomer and ranged from 1.2 - 0.07 to 42 - 3.9 µg/cm2 at 1 year and from 2.3 - 0.16 to 79 - 6 µg/cm2 at 3 years.
HCV antibodies in saliva and urine (1998)

Infection with hepatitis C virus (HCV) is usually established by detection of serum antibodies (anti-HCV). This study was conducted in order to evaluate whether saliva and urine may substitute serum for anti-HCV detection. Serum, saliva, and urine were obtained simultaneously from 141 patients with a variety of liver diseases and from 52 patients with autoimmune diseases (systemic lupus erythematosus n = 27 and rheumatoid arthritis n = 25). The cell free fraction of saliva and urine samples was tested for anti-HCV using a modification of a serum anti-HCV kit. Western blot analysis was used as a confirmation method. Of the patients with liver diseases, 73 were anti-HCV-seropositive. Salivary and urinary anti-HCV could be detected in 66 (90%) and 36 (49%) of the anti-HCV-serpositive patients, respectively. The presence of anti-HCV in saliva or urine was not related to the severity of liver disease. All the anti-HCV-seronegative liver patients were negative for salivary anti-HCV and 22 (32%) had urinary anti-HCV. The patients with autoimmune diseases were all anti-HCV-seronegative. None had detectable salivary anti-HCV while 33 (63%) were positive for urinary anti-HCV. Western Blot analysis confirmed the presence of anti-HCV in all serum and saliva samples tested but only in 2/12 urine samples. The results suggest that saliva, but not urine, may serve as a substitute for serum for the determination of anti-HCV positivity. J. Med. Virol. 55:24–27, 1998. © 1998 Wiley-Liss, Inc.
Zubaida (Sami) Islam, the People and the State. Essays on Political Ideas and Movements in the Middle East (1992)

Richard Yann. Zubaida (Sami) Islam, the People and the State. Essays on Political Ideas and Movements in the Middle East. In: Archives de sciences sociales des religions, n°80, 1992. p. 298.
Mixed H<inf>2</inf> / H<inf>&#x221E;</inf> optimal control for three-phase Grid Connected Converter (2015)

Three-phase Grid Connected Converter (GCC), which acts as an important component for integrating the renewable energy into the smart grid, are attracting a great deal of attention. Traditionally, GCC are controlled with proportional plus integrator (PI) or Proportional plus resonant (PR) controllers in the rotating synchronous frame or stationary frame, respectively. However, those mechanisms show slowly response times for tracking the changing reference commands without considering the uncertainty and volatility in the grid. This paper investigates how to mitigate such restrictions using a mixed H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> / H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> controller to control a grid-connected converter. The proposed controller ensures: a) the resulting closed-loop system is asymptotically stable for all admissible parameter uncertainties b) the given transient performance index can be guaranteed under uncertainties and disturbance. Simulation results show good transient and steady performance than the traditional PI control methods.
Laticifer Ultrastructure and Differentiation in Seedlings of Papaver bracteatum Lindl., Population Arya II (Papaveraceae) (1978)

Laticifers of Papaver bracteatum Lindl., population Arya II, seedlings were examined by electron microscopy. Laticifers were first differentiated in procambium of the radicle associated with phloem about 72 hr after seeds were sown. Proliferation of membrane-bound vesicles of apparent endoplasmic reticulum origin distinguished laticifers from adjacent cells. Vesicles developed electron-dense caps from the internal condensation of small particles. Laticifer initials possessed the usual complement of organelles that became obscured in mature cells by the large, closely packed vesicles. Plastids contained an electron-dense, membrane-bound inclusion, but never developed lamellae or starch grains. Articulation and anastomoses between laticifer elements resulted from gradual removal of wall materials by both cells on opposite sides of the common walls at a perforation site. Differentiation of the laticifer initials and the micromorphology of the protoplast of P. bracteatum is similar to that reported for P. somniferum.
A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies (2017)

The combination of BEZ235 and everolimus demonstrated limited efficacy and tolerance. BEZ235 systemic exposure increased in a dose-proportional manner while oral bioavailability was quite low, which may be related to gastrointestinal-specific toxicity. The changes in steady-state pharmacokinetics of everolimus with BEZ235 highlight potential drug-drug interactions when these two drugs are administered together. Clinicaltrials.gov: NCT01508104.
Automatic detection of uncertainty in spontaneous German dialogue (2015)

Uncertainty is ubiquitous in natural human communication. Human listeners assess the speaker’s degree of uncertainty at any time in communication and use this information to shape dialogue. In contrast, currently available computer systems dealing with spoken language are usually not built to perform this task. The ability to detect uncertainty would likely lead to more natural human-computer dialogue. In order to detect uncertainty automatically, we extract linguistic, paralinguistic and dialogue-related features from the Kiel Corpus, a corpus of naturalistic task-oriented spoken German. We then use these features to train a random forests model. Our experimental results show that relatively high classification accuracy can be obtained while employing only 64 well-chosen features (73% accuracy, 69% F1). To our best knowledge, this is the first study of automatic uncertainty detection using German speech data as well as the first achieving good performance on everyday speech.
On profile optimization in DOCSIS 3.1 networks exploiting traffic information (2018)

The latest release of the Data over Cable Service Interface Specification (DOCSIS), namely DOCSIS 3.1, has introduced the use of adaptive bit loading profiles. The optimal design of these profiles is critical for the overall performance of a Hybrid Fiber Coaxial (HFC) cable system. In this thesis, we introduce a low complexity profile design algorithm that maximizes the average throughput of a HFC system by grouping its cable modems (CMs) on the basis of both their downstream data arrival rates and channel signal-to-noise ratios (SNRs). Optimizing the profiles on the basis of both CM traffic and CM channel SNRs is challenging as these two criteria are somewhat contradictory. To account for the CMs' channel SNRs, CMs with similar SNR distributions should be grouped into the same profiles. However, to take into account the CMs' traffic, CMs with high data arrival rates should be grouped into profiles with higher bit loading capabilities, and CMs with lower data arrival rates should be grouped into profiles with lower bit loading capabilities.%, irrespective of their channel SNRs. In this thesis, we take into account these two contradictory criteria in the profile optimization problem, and we propose a sub-optimal solution to solve this problem. Performance analysis results of our algorithm show that accounting for both CM channel SNR and CM traffic can improve the average throughput of a HFC system. Furthermore, our approach accounts for the CMs' traffic without requiring future knowledge of their actually realized data arrival rates, which is difficult to obtain in practice. We also consider an asymptotic scenario, where the per-profile arrival rates (which is the sum of the arrival rates of all the CMs in a profile) is always guaranteed to be less than the respective per-profile bit loading capacities. For this case, our algorithm optimizes the system profiles with the objective of minimizing the system's total average data transmission time. We show that our proposed approach yields significantly high performance, particularly for scenarios with a high degree of heterogeneity in the CMs' traffic.
Surface relief gratings generated by a photocrosslinkable polymer with styrylpyridine side chains (2000)

The formation of holographic surface relief gratings on thin films of a liquid-crystalline polymethacrylate with styrylpyridine side chains is described. A film of the polymer was treated with hydrogen chloride to protonate the side chain moieties, followed by holographic exposure to p-polarized Ar+ laser beams at 488 nm and by post-exposure baking to give rise to surface relief gratings. The depth of the surface relief in a typical case was 15 nm which is approximately 15% of the original film thickness. On the basis of the temperature dependence of diffraction efficiencies of the grating, the mechanism of the generation of the relief gratings is discussed.
Expanding task functionality in established humanoid robots (2007)

Many humanoid robots like ASIMO are built to potentially perform more than one type of task. However, the need to maintain a consistent physical appearance of the robot restricts the installation of additional sensors or appendages that would alter its visual identity. Limited battery power for free-moving locomotive robots places temporal and spacial complexity limits on the algorithms we can deploy on the robot. With these conditions in mind, we have developed a distributed robot architecture that combines onboard functionality with external system modules to perform tasks involving interaction with the environment. An information model called the Cognitive Map organizes output produced by multiple perceptual modules and presents a common abstraction interface for other modules to access the information. For the planning and generation of motion on the robot, the Task Matrix embodies a task abstraction model that maps a high level task description into its primitive motions realizable on the robot. Our architecture supports different control paradigms and information models that can be tailored for specific tasks. We demonstrate environmental tasks we implemented with our system, such as pointing at moving objects and pushing an object around a table in simulation and on the actual ASIMO robot.
Endogenous digoxin‐like factor in acute myocardial infarction (1994)

The results show an increase of plasma EDLF during the 1st day after AMI, and that higher plasma EDLF may be associated with the development of ventricular arrhythmias.
Effect of Size, Surface Charge, and Hydrophobicity of Poly(amidoamine) Dendrimers on Their Skin Penetration (2012)

The barrier functions of the stratum corneum and the epidermal layers present a tremendous challenge in achieving effective transdermal delivery of drug molecules. Although a few reports have shown that poly(amidoamine) (PAMAM) dendrimers are effective skin-penetration enhancers, little is known regarding the fundamental mechanisms behind the dendrimer-skin interactions. In this Article, we have performed a systematic study to better elucidate how dendrimers interact with skin layers depending on their size and surface groups. Franz diffusion cells and confocal microscopy were employed to observe dendrimer interactions with full-thickness porcine skin samples. We have found that smaller PAMAM dendrimers (generation 2 (G2)) penetrate the skin layers more efficiently than the larger ones (G4). We have also found that G2 PAMAM dendrimers that are surface-modified by either acetylation or carboxylation exhibit increased skin permeation and likely diffuse through an extracellular pathway. In contrast, amine-terminated dendrimers show enhanced cell internalization and skin retention but reduced skin permeation. In addition, conjugation of oleic acid to G2 dendrimers increases their 1-octanol/PBS partition coefficient, resulting in increased skin absorption and retention. Here we report that size, surface charge, and hydrophobicity directly dictate the permeation route and efficiency of dendrimer translocation across the skin layers, providing a design guideline for engineering PAMAM dendrimers as a potential transdermal delivery vector.
Políticas del francés: actores, experiencias y perspectivas (2006)

Se propone un examen de los modelos de gestión de las lenguas en la Francofonía con el fin de aportar a la reflexión para el diseño de políticas lingüísticas iberoamericanas.\n\nLa situación del francés en el mundo es, desde varios puntos de vista, comparable a las del español y el portugués. Frente a las posibilidades de desarrollo que a cada una se le ofrecen, las tres lenguas en encuentran sin embargo en situaciones distintas, y esto se debe no sólo a factores objetivos tales como el peso económico o político de sus comunidades de hablantes, las perspectivas de crecimiento demográfico en cada caso o la fluctuación de la demanda internacional de lenguas extranjeras sino, sobre todo, a la diferente capacidad que tienen las instancias representativas de cada área idiomática para definir y llevar adelante una política lingüística. El análisis de los dispositivos institucionales y algunos programas de cooperación lingüística del área más activa en este campo, la francófona, puede sugerir vías de acción para la gestión de las lenguas en el ámbito iberoamericano.
Abstracts of Bell System Technical Papers Not Published in This Journal (1952)

Low terminal costs and single-cable operation make this the first economically practical carrier system for medium-haul telephone circuits. Performance is not sacrificed for economy.
INFLUENCE OF SODIUM PHOSPHATE ON THE HEAT STABILITY OF BUFFALO MILK AND ITS CONCENTRATE (1985)

The influence of three different concentrations, 0.05%, 0.10% and 0.15% of monobasic sodium phosphate on the heat stability (at 130°C) and pH of buffalo milk and its 2:1 concentrate was determined. It was observed that sodium phosphate caused a considerable increase in the heat stability, determined as heat coagulation time (HCT) of concentrated buffalo milk. The optimum concentration of sodium phosphate for imparting maximum stability to the concentrate was different for different samples. However, with the addition of an appropriate concentration of sodium phosphate it was possible to manufacture evaporated milk up to 36% total solids. Depending on the HCT/pH profile, some of the samples of fluid (unconcentrated) milk were stabilized while the others were destabilized due to the addition of sodium phosphate. Addition of monobasic sodium phosphate caused a decrease in the pH of fluid milk and its concentrate.
Synthesis of a β1,2-Mannopyranosyl Tetrasaccharide Found in the Phosphomannan Antigen of <i>Candida </i><i>albicans</i> (2000)

The synthesis of a portion of the challenging beta1,2-mannosyl polymer found in the cell walls of Candida albicans was undertaken to develop a conjugate vaccine against C. albicans and to facilitate NMR conformational studies of this unique polysaccharide. The novel approach to the synthesis of tetrasaccharide 1 employed the modified ulosyl bromide 11 as the glycosyl donor which provided high diastereoselectivity. A participating solvent as well as p-chlorobenzyl protection facilitated the new approach.