gebhart/patrepeval huggingface dataset:
The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma (2015)

The vacuolar H+ ATPase (V-ATPase) is a proton pump responsible for acidification of cellular microenvironments, an activity exploited by tumors to survive, proliferate and resist to therapy. Despite few observations, the role of V-ATPase in human tumorigenesis remains unclear.We investigated the expression of ATP6V0C, ATP6V0A2, encoding two subunits belonging to the V-ATPase V0 sector and ATP6V1C, ATP6V1G1, ATPT6V1G2, ATP6V1G3, which are part of the V1 sector, in series of adult gliomas and in cancer stem cell-enriched neurospheres isolated from glioblastoma (GBM) patients. ATP6V1G1 expression resulted significantly upregulated in tissues of patients with GBM and correlated with shorter patients' overall survival independent of clinical variables.ATP6V1G1 knockdown in GBM neurospheres hampered sphere-forming ability, induced cell death, and decreased matrix invasion, a phenotype not observed in GBM monolayer cultures. Treating GBM organotypic cultures or neurospheres with the selective V-ATPase inhibitor bafilomycin A1 reproduced the effects of ATP6V1G1 siRNA and strongly suppressed expression of the stem cell markers Nestin, CD133 and transcription factors SALL2 and POU3F2 in neurospheres.These data point to ATP6V1G1 as a novel marker of poor prognosis in GBM patients and identify V-ATPase inhibition as an innovative therapeutic strategy for GBM.
Comparative toxicity of free ions and complexes of copper and amino acids to Candida utilis (1971)

The toxicity of complexes formed by copper with glycine, aspartic and glutamic acids, arginine, and ornithine was studied on a medium whose organic components do not form complexes with copper. All copper was found to enter into a complex with amino acids at pH 7.0. At more acid pH values, Cu/sup 2 +/ ions are present in the medium along with copper complexes. The copper concentration which reduces the mean growth rate of Candida utilis by 50%, varies within a range of 0.02-0.05 mM for all amino acids tested (the copper: amino acid ratio being 1:2). Increasing the amino acid concentration in the medium reduces the toxicity of copper complexes. Changing the pH toward alkaline values also reduces the toxicity of copper-amino acid complexes. The factors are discussed which produce an identical effect when parameters such as pH and amino acid concentration are changed.
Phase noise modelling and mitigation techniques in ofdm communications systems (2009)

This paper addresses the analysis and mitigation of the signal distortion caused by oscillator phase noise (PN) in OFDM communications systems. Two new PN mitigation techniques are proposed, especially targeted for reducing the intercarrier interference (ICI) effects due to PN. The first proposed method is a fairly simple one, stemming from the idea of linearly interpolating between two consecutive common phase error (CPE) estimates to obtain a linearized estimate of the time- varying phase characteristics. The second technique, in turn, is an extension to the existing state-of-the-art ICI estimation methods. Here the idea is to use an additional interpolation stage to improve the phase estimation performance around the boundaries of two consecutive OFDM symbols. The paper also verifies the performance improvement of these new PN estimation techniques by comparing them to the existing state- of-the-art techniques using extensive computer simulations. To emphasize practicality, the simulations are carried out in 3GPP-LTE downlink -like system context, covering both additive white Gaussian noise (AWGN) and extended ITU-R Vehicular A multipath channel types.
Water Deficit and Abscisic Acid Cause Differential Inhibition of Shoot <i>versus</i> Root Growth in Soybean Seedlings (1990)

Roots often continue to elongate while shoot growth is inhibited in plants subjected to low-water potentials. The cause of this differential response to water deficit was investigated. We examined hypocotyl and root growth, polysome status and mRNA populations, and abscisic acid (ABA) content in etiolated soybean (Glycine max [L.] Merr. cv Williams) seedlings whose growth was inhibited by transfer to low-water potential vermiculite or exogenous ABA. Both treatments affected growth and dry weight in a similar fashion. Maximum inhibition of hypocotyl growth occurred when internal ABA levels (modulated by ABA application) reached the endogenous level found in the elongating zone of seedlings grown in water-deficient vermiculite. Conversely, root growth was affected to only a slight extent in low-water potential seedlings and by most ABA treatments (in some, growth was promoted). In every seedling section examined, transfer of seedlings into low-water potential vermiculite caused ABA levels to increase approximately 5- to 10-fold over that found in well-watered seedlings. Changes in soluble sugar content, polysome status, and polysome mRNA translation products seen in low-water potential seedlings did not occur with ABA treatments sufficient to cause significant inhibition of hypocotyl elongation. These data suggest that both variation in endogenous ABA levels, and differing sensitivity to ABA in hypocotyls and roots can modulate root/shoot growth ratios. However, exogenous ABA did not induce changes in sugar accumulation, polysome status, and mRNA populations seen after transfer into low-water potential vermiculite.
Electrically Conductive and Wear Resistant Si<sub>3</sub>N<sub>4</sub>-Based Composites with TiC<sub>0.5</sub>N<sub>0.5</sub> Particles for Electrical Discharge Machining (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Scalable RDF store based on HBase and MapReduce (2010)

The growing size of Resource Description Framework (RDF) dataset requires RDF repository to be excellent scalable and highly efficient. Distributed and parallel processing model meets the urgent needs naturally. In this paper, we propose a scalable RDF store based on HBase, which is a distributed, column-oriented database modeled after Google's Bigtable. Our approach adopts the idea of Hexastore and considers both RDF data model and HBase capability. We store RDF triples into six HBase tables (S_PO, P_SO, O_SP, PS_O, SO_P and PO_S) which covers all combinations of RDF triple patterns. And we index them with HBase provided index structure on row key. Besides presenting the storage schema, we also propose a MapReduce strategy for SPARQL Basic Graph Pattern (BGP) processing, which is suitable for our storage schema. It uses multiple MapReduce jobs to process a typical BGP. In each job, it uses a greedy method to select join key and eliminates multiple triple patterns. The evaluation result indicates that our approach works well against large RDF dataset.
Prostaglandin moieties that determine receptor binding specificity in the bovine corpus luteum (1999)

This study provided a pharmacological evaluation of prostaglandin binding to bovine luteal plasma membrane. It was found that [3H]PGF2 alpha' [3H]PGE2' [3H]PGE1 and [3H]PGD2 all bound with high affinity to luteal plasma membrane but had different specificities. Binding of [3H]PGF2 alpha and [3H]PGD2 was inhibited by non-radioactive PGF2 alpha (IC50 values of 21 and 9 nmol l-1, respectively), PGD2 (35 and 21 nmol l-1), and PGE2 (223 and 81 nmol l-1), but not by PGE1 (> 10,000 and 5616 nmol l-1). In contrast, [3H]PGE1 was inhibited by non-radioactive PGE1 (14 nmol l-1) and PGE2 (7 nmol l-1), but minimally by PGD2 (2316 nmol l-1) and PGF2 alpha (595 nmol l-1). Binding of [3H]PGE2 was inhibited by all four prostaglandins, but slopes of the dissociation curves indicated two binding sites. Binding of [3H]PGE1 was inhibited, resulting in low IC50 values, by pharmacological agonists that are specific for EP3 receptor and possibly EP2 receptor. High affinity binding of [3H]PGF2 alpha required a C15 hydroxyl group and a C1 carboxylic acid that are present on all physiological prostaglandins. Specificity of binding for the FP receptor depended on the C9 hydroxyl group and the C5/C6 double bond. Alteration of the C11 position had little effect on affinity for the FP receptor. In conclusion, there is a luteal EP receptor with high affinity for PGE1' PGE2' agonists of EP3 receptors, and some agonists of EP2 receptors. The luteal FP receptor binds PGF2 alpha' PGD2 (high affinity), and PGE2 (moderate affinity) but not PGE1 due to affinity determination by the C9 and C5/C6 moieties, but not the C11 moiety.
Embedding formally proved code in a smart card: converting B to C (2002)

Smart cards are small embedded devices with strong security requirements. To fulfil those requirements, formal methods appear as promising techniques. The B method has already been used to model smart-card components. However, smart cards have also very strong programming constraints, both for memory usage and computing power. Currently, the code generated from a B specification does not meet those constraints. This paper presents some classical optimisation techniques that are well-suited for B specifications and that need to be included within a code generator to embed this generated code.
SiGe bipolar technology for automotive radar applications (2004)

A SiGe bipolar technology for automotive radar applications around 77 GHz has been developed. A cut-off frequency of 200 GHz, a maximum oscillation frequency of 275 GHz, and a gate delay of 3.5 ps have been obtained. First key building blocks for 77 GHz systems like VCOs and mixers have been realized with this technology.
Effects of IGF-I and GH treatment on bone metabolism and bone density, with special reference to GH deficiency (1995)

Effects of IGF-I and GH treatment on bone metabolism and bone density, with special reference to GH deficiency
Genetic Linkage in Soybeans: Linkage Group VII<sup>1</sup> (1970)

The genetic linkage between three loci in soybeans was determined, and established as Linkage Group VII. The loci involved arc Y 13 , y 13 (normal, deficient chlorophyll); 0, o (brown, red‐brown seed coat pigmentation); and I, i l , i k , i (multiple alleles determining the seed coat pattern of black and brown colors). The combined recombination value between the y 13 and o loci was 31.3 ± 1.9%, between the o and i loci 17.8 ± 0.79%, and between the y 13 and i loci 41.1 ± 0.9%. The order of genes was shown to be y 13 ‐ o ‐ i.
Dielectric and Structural Characteristics in Barium Lanthanum Magnesium Niobate (2000)

The dielectric properties and their related microstructural characteristics in solid solutions of (1 — x )Ba(Mg 1/3 Nb 2/3 )O 3 (BMN)— x La(Mg 2/3 Nb 1/3 )O 3 (LMN) (BLMN) were investigated by measuring the relative permittivity (ɛ r ), Q value, and temperature coefficient of resonator frequency (τ f ), and by observing the microstructure using transmission electron microscopy. The trend of variation of the temperature coefficient of the dielectric permittivity (τ ɛ ) was the same for our solid solutions as that reported by Reaney et al . When the tolerance factor ( t ) was >1.01 in BLMN with composition x = 0 to 1.0, where the tilting of oxygen octahedra was not involved, the components of the microstructure included a disordered and transition phase as well 1:1 and 1:2 ordered phases. In the region where 1.01 < t < 0.96 with x = 0.2 to 0.7, the 1:1 order, the disorder, and the phase due to the antiphase tilting of oxygen octahedra were present. Finally, in the region where t < 0.96 with x = 0.7 to 1.0, the microstructure of BLMN was the same as that of the pure LMN, including the 1:1 order and the antiphase, inphase tilting of oxygen octahedra, and the antiparallel shift of A‐site cations.
Intelligent learning environment: building hybrid system from standard application and Web application (2005)

In this paper, we explore the idea of intelligent learning environment (ILE) by building a system for teaching and learning music in a Web-based environment. Our system is a framework that utilises existing Web architecture. Instead of using a standard Web browser as our client tool, we are going to develop our own. By following this, some design issues regarding the shifting and their solutions are addressed. In a nutshell, this environment allows us to gain more control in monitoring students' learning activities within a single environment while keeping instructors away from a bundle of computer codes.
Total Antioxidant Capacity of Arginine-Conjugated Linoleic Acid (CLA) Complex (2004)

Conjugated linoleic acids (CLA) have shown diverse biological activities, including anti-carcinogenic, anti-atherosclerotic, anti-adipogenic, and anti-diabetogenic effects. Recent reports also showed that CLA has free radical scavenging capacity, which may give health benefits to human beings. However, the application of CLA as a bioactive ingredient has been limited due to its insolubility in water. To overcome this problem, we investigated antioxidant activities of arginine (Arg)-CLA, a water-soluble CLA salt, using both 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. CLA, Arg, and Arg-CLA all exerted radical scavenging activities in a dose-dependent manner in both assays. Arg-CLA at 20 mM scavenged 89 and 55% of ABTS and DPPH radicals in 3 h, respectively, whereas CLA alone quenched only 48 and 26% of them under the same conditions. The antioxidant activity of the Arg-CLA complex was found to be synergistic in ABTS assay and comparable to that of vitamin E in DPPH assay.
A composite CMOS gate array with 4K RAM and 128K ROM (1986)

A unique gate array structure, called a composite gate array, incorporating a RAM and a ROM along with ordinary gate arrays, is described. The composite gate array consists of a 128K ROM, a 4K RAM, and a 6K gate array, and is developed using 1.6-/spl mu/m CMOS technology. The RAM and ROM are partitioned into four 1K and eight 16K blocks for increasing flexibility of memory configuration. A distributed arrangement of memory blocks is used to permit completely automatic writing using fewer channels. In circuit performance, gate delay time is 1.0 ns, RAM access time is 25 ns, and ROM access time is 30 ns. A communication control processor for personal computer networks is successfully designed to demonstrate the feasibility of the gate array.
Salicylic Acid Induces Resistance to <i>Alternaria solani</i> in Hydroponically Grown Tomato (1999)

ABSTRACT Alternaria solani is the causal agent of early blight disease in tomato and is responsible for significant economic losses sustained by tomato producers each year. Because salicylic acid (SA) is an important signal molecule that plays a critical role in plant defense against pathogen invasion, we investigated if the exogenous application of SA would activate systemic acquired resistance (SAR) against A. solani in tomato leaves. The addition of 200 muM SA to the root system significantly increased the endogenous SA content of leaves. Free SA levels increased 65-fold over basal levels to 5.85 mug g(-1) fresh weight (FW) after 48 h. This level of SA had no visible phytotoxic effects. Total SA content (free SA + SA-glucose conjugate) increased to 108 mug g(-1) FW after 48 h. Concomitant with elevated SA levels, expression of the tomato pathogenesis-related (PR)-1B gene was strongly induced within 24 h of the addition of 200 muM SA. PR-1B expression was still evident after 48 h; however, PR-1B induction was not observed in plants not receiving SA treatment. Challenge inoculation of SA-treated tomato plants using conidia of A. solani resulted in 83% fewer lesions per leaf and a 77% reduction in blighted leaf area as compared with control plants not receiving SA. Our data indicate that root feeding 200 muM SA to tomato plants can (i) significantly elevate foliar SA levels, (ii) induce PR-1B gene expression, and (iii) activate SAR that is effective against A. solani.
Passive Nondestructive Assay of Nuclear Materials (1991)

The term nondestructive assay (NDA) is applied to a series of measurement techniques for nuclear fuel materials. The techniques measure radiation induced or emitted spontaneously from the nuclear material; the measurements are nondestructive in that they do not alter the physical or chemical state of the nuclear material. NDA techniques are characterized as passive or active depending on whether they measure radiation from the spontaneous decay of the nuclear material or radiation induced by an external source. This book emphasizes passive NDA techniques, although certain active techniques like gamma-ray absorption densitometry and x-ray fluorescence are discussed here because of their intimate relation to passive assay techniques. The principal NDA techniques are classified as gamma-ray assay, neutron assay, and calorimetry. Gamma-ray assay techniques are treated in Chapters 1--10. Neutron assay techniques are the subject of Chapters 11--17. Chapters 11--13 cover the origin of neutrons, neutron interactions, and neutron detectors. Chapters 14--17 cover the theory and applications of total and coincidence neutron counting. Chapter 18 deals with the assay of irradiated nuclear fuel, which uses both gamma-ray and neutron assay techniques. Chapter 19 covers perimeter monitoring, which uses gamma-ray and neutron detectors of high sensitivity to check that no unauthorized nuclear material crosses a facility boundary. The subject of Chapter 20 is attribute and semiquantitative measurements. The goal of these measurements is a rapid verification of the contents of nuclear material containers to assist physical inventory verifications. Waste and holdup measurements are also treated in this chapter. Chapters 21 and 22 cover calorimetry theory and application, and Chapter 23 is a brief application guide to illustrate which techniques can be used to solve certain measurement problems.
Purification and Developmental Analysis of the Major Anionic Peroxidase from the Seed Coat of <i>Glycine max</i> (1991)

We show that the majority of peroxidase activity in soybean (Glycine max var Williams 82) seeds is localized to the seed coat. A single isozyme is responsible for this activity and has been purified to electrophoretic homogeneity by successive chromatography on DEAE Sepharose Fast Flow, concanavalin A-Sepharose, and Sephadex G-75. The peroxidase exhibits a pl of 4.1, an apparent molecular mass of 37 kilodaltons, and has properties characteristic of a glycoprotein. The enzyme begins to accumulate approximately 21 days after anthesis and continues to do so throughout the maturation of the seed coat where it can represent at least 5% of the soluble protein in dry seed coats. Due to its localization in the seed, we propose that this isozyme may play a role in the hardening of the seed coat.
The development of language processing support for the ViSiCAST project (2000)

ViSiCAST is a major new project funded by the European Union, aiming to provide improved access to services and facilities for deaf citizens through sign language presented by a virtual human, or avatar. We give here an outline of the project, and describe early work in the area of linguistics and language processing. This work covers two distinct but related areas: first, the development of an XML-compliant notation for deaf sign language gestures, which can be used to drive the signing avatar; and, second, the development of a framework supporting the translation of natural language text into this gesture-orientated notation.
Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation (2012)

Lipids constitute 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain, and an animal model of MS to explore the role of the identified lipids in autoimmune demyelination. We found that autoantibodies in MS target a phosphate group in phosphatidylserine and oxidized phosphatidylcholine derivatives. Administration of these lipids ameliorated experimental autoimmune encephalomyelitis by suppressing activation and inducing apoptosis of autoreactive T cells, effects mediated by the lipids' saturated fatty acid side chains. Thus, phospholipids represent a natural anti-inflammatory class of compounds that have potential as therapeutics for MS.
Isolation and characterization of two putative full-length Drosophila U4 small nuclear RNA genes. (1986)

U4 RNA is one of the abundant small nuclear RNAs implicated in the processing of the 3' -ends of premessenger RNAs (Berget, S. (1984) Nature 309, 179-182). Two potential U4 RNA genes were isolated from a Drosophila genomic DNA library and characterized. These genes, which were from different loci, had transcription and processing signals common to Drosophila U1 and U2 small nuclear RNA genes. One U4 gene locus also contained a downstream 5'-truncated U4 pseudogene. This is the first report in which putative full-length genes for U4 small nuclear RNA were isolated and characterized.
Sterically Protected N<sub>2</sub>O-Type Benzopyrromethene Boron Complexes from Boronic Acids with Intense Red/Near-Infrared Fluorescence (2017)

A series of N<sub>2</sub>O-type benzopyrromethene boron complexes have been synthesized from the condensation of pyrrole, formylisoindole, and various boronic acids. These dyes have red/near-infrared absorption, high solution- and solid-state fluorescence, as well as good solubility in a variety of solvents due to the presence of axial-substituted groups that provide steric protection and prevent their possible aggregations. Two water-soluble derivatives with pyridinium ions were developed as near-infrared excitable mitochondrially localizing fluorescent probes.
Alteration of Regional Homogeneity within the Sensorimotor Network after Spinal Cord Decompression in Cervical Spondylotic Myelopathy: A Resting-State fMRI Study (2015)

There is a lack of longitudinal research to evaluate the function of neurons' adaptive changes within the sensorimotor network (SMN) following recovery after cervical cord decompression. Regional homogeneity (ReHo) may provide information that is critical to fully understand CSM-related functional neural synchrony alterations. The purpose of this study was to assess the ReHo alterations of resting state-functional MRI (rs-fMRI) within pre- and postdecompression CSM and healthy controls (HC) and its correlations with clinical indices. Predecompression CSM demonstrated a significantly lower ReHo in the left primary sensory cortex and primary motor cortex (PostG/PreG) but enhanced ReHo in the right superior parietal lobule (SPL) compared with HC. In comparison with predecompression CSM, the postdecompression CSM showed increased ReHo in the left PostG/PreG but significantly lower ReHo in the right SPL compared with HC patients. Abnormal ReHo regions in pre- or postdecompression CSM showed no significant correlation with the Japanese Orthopaedic Association (JOA) scores, Neck Disability Index (NDI) scores, and disease duration (P > 0.05). This result demonstrated disrupted regional homogeneity within SMN in CSM. This adaptive change in the brain may favor the preservation of sensorimotor networks before and after cervical cord decompression and clinical symptoms independent of ReHo within SMN.