gebhart/patrepeval huggingface dataset:
Müllerian inhibiting substance in reproduction and cancer (1992)

During embryogenesis normal male phenotypic development requires the action of Müllerian Inhibiting Substance (MIS) which is secreted by Sertoli cells of the fetal testis. As testes differentiate in genetic (XY) males, they produce MIS which causes regression of the Müllerian ducts, the anlagen of the female reproductive tract. Soon thereafter, testicular androgens stimulate the Wolffian ducts. In females, on the other hand, MIS is not produced by grandulosa cells until after birth, before which, estrogens induce Müllerian duct development, while the Wolffian ducts passively atrophy in the absence of androgenic stimulation. High serum MIS levels in males are maintained until puberty, whereupon they fall to baseline levels. In females MIS is undetectable in serum until the peripubertal period when values approach the baseline levels of males. This distinct pattern of sexual and ontogenic expression presupposes and requires tight regulation. MIS may play a role in gonadal function and development. Our laboratory has shown that an important role for ovarian MIS is to inhibit oocyte meiosis, perhaps providing maximal oocyte maturation prior to selection for ovulation and subsequent fertilization. Furthermore, Vigier et al. (Development 100:43-55) have recently obtained evidence that MIS may influence testicular differentiation, coincident with inhibition of aromatase activity. Current structure-function studies demonstrate that MIS, like other growth regulators in its protein family, requires proteolytic cleavage to exhibit full biological activity. MIS can be inhibited by epidermal growth factor. This antagonism, which is common to all MIS functions so far investigated, is associated with inhibition of EGF receptor autophosphorylation. We have provided evidence that bovine MIS can inhibit female reproductive tract tumors arising in adults.(ABSTRACT TRUNCATED AT 250 WORDS)
In-Space Transportation with Tethers (1998)

Any analysis of electrodynamic tethers for Space Station applications will soon arrive at the conclusion that currents on the order of 10 A are required. For power generation, we have to foresee needs of several kilowatts even for an emergency backup system. For reboost, we need thrust forces on the order of a Newton, due to the large aerodynamic drag of the Station. In addition, we are restricted by the need to keep perturbations to the Station environment to a minimum. Very long tethers are ruled out by this condition, as they would move the system's center of gravity too much and pose additional operational problems when the Station is docking with other spacecraft. It is easy to show that "standard" tether systems, such as TSS-1, which rely on a large spherical surface to collect electron current from the ionosphere, are unsuitable for ISS applications. A study conducted by MSFC into the possible use of the TSS - 1/R system on the Space Station came to the conclusion that it did not make sense. A quick calculation, using the 10 A benchmark, shows why. TSS-LR collected I A, while the satellite was biased to 1.5 kV. This was twice what had been predicted. Even so, the current collected by the satellite was observed to increase only as the square root of the bias voltage. Thus, to achieve 10 A with the TSS-1 system under the same (daytime) conditions would require a bias voltage of 150 kV, or a tether length of over 850 km! Going to a larger surface would help some, but there is a strong law of diminishing returns for that route. Even if very large spheres were to be allowed (say of 8 m radius), which might achieve useful power levels during optimal conditions of daytime plasma densities with a tether 10 km long, they would suffer from the other Achilles heel of passive spherical collectors: a strong drop in the current (and power goes as the square of the current), as the low plasma densities are encountered during the third of the orbit which is in the Earth's shadow.
119. Studies in electro-endosmosis. Part VI. The “bubble-tube” method of measurement (1935)

F. Fairbrother and A. E. Stubbs, J. Chem. Soc., 1935, 527 DOI: 10.1039/JR9350000527
Eighth workshop on mining and learning with graphs (2011)

The Eighth Workshop on Mining and Learning with Graphs (MLG)1was held at KDD 2010 in Washington DC. It brought together a variete of researchers interested in analyzing data that is best represented as a graph. Examples include the WWW, social networks, biological networks, communication networks, and many others. The importance of being able to effectively mine and learn from such data is growing, as more and more structured and semi-structured data is becoming available. This is a problem across widely different fields such as economics, statistics, social science, physics and computer science, and is studied within a variety of sub-disciplines of machine learning and data mining including graph mining, graphical models, kernel theory, statistical relational learning, etc. The objective of this workshop was to bring together practitioners from these various fields and areas to foster a rich discussion of which problems we work on, how we frame them in the context of graphs, which tools and algorithms we apply and our general findings and lessons learned. This year's workshop was very successful with well over 100 attendees, excellent keynote speakers and papers. This is a rapidly growing area and we believe that this community is only in its infancy. We hope that the readers will join us next year for MLG 2011.
Association of tumor necrosis factor α polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort (2006)

This study showed an association between the TNFA -308 polymorphism and progression of radiographic damage in patients with early seropositive RA. This association appeared to be independent of the SE, but might be dependent on other genetic variants in linkage disequilibrium with the -308 TNFA A allele and DRB1*0301. Further studies should be conducted to validate these results in both longitudinal observational cohorts and randomized clinical trials.
Protocol: a simple method for extracting next-generation sequencing quality genomic DNA from recalcitrant plant species (2014)

Next-generation sequencing technologies rely on high quality DNA that is suitable for library preparation followed by sequencing. Some plant species store large amounts of phenolics and polysaccharides within their leaf tissue making genomic DNA extraction difficult. While many DNA extraction methods exist that contend with the presence of phenolics and polysaccharides, these methods rely on long incubations, multiple precipitations or commercially available kits to produce high molecular weight and contaminant-free DNA. In this protocol, we describe simple modifications to the established CTAB- based extraction method that allows for reliable isolation of high molecular weight genomic DNA from difficult to isolate plant species Corymbia (a eucalypt) and Coffea (coffee). The simplified protocol does not require multiple clean up steps or commercial based kits, and the isolated DNA passed stringent quality control standards for whole genome sequencing on Illumina HiSeq and TruSeq sequencing platforms.
Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model (2007)

The disseminated characteristics of human glioblastoma multiforme (GBM) make it a particularly difficult tumor to treat with long-term efficacy. Most preclinical models of GBM involve treatment of a single tumor mass. For therapeutic outcomes to translate from the preclinical to the clinical setting, induction of an antitumor response capable of eliminating multifocal disease is essential. We tested the hypothesis that expression of Flt3L (human soluble FMS-like tyrosine kinase 3 ligand) and TK (herpes simplex virus type 1-thymidine kinase) within brain gliomas would mediate regression of the primary, treated tumor mass and a secondary, untreated tumor growing at a distant site from the primary tumor and the site of therapeutic vector injection. In both the single-GBM and multifocal-GBM models used, all saline-treated control animals succumbed to tumors by day 22. Around 70% of the animals bearing a single GBM mass treated with an adenovirus expressing Flt3L (AdFlt3L) and an adenovirus expressing TK (AdTK + GCV) survived long term. Approximately 50% of animals bearing a large primary GBM that were implanted with a second GBM in the contralateral hemisphere at the same time the primary tumors were being treated with AdFlt3L and AdTK also survived long term. A second multifocal GBM model, in which bilateral GBMs were implanted simultaneously and only the right tumor mass was treated with AdFlt3L and AdTK, also demonstrated long-term survival. While no significant difference in survival was found between unifocal and multifocal GBM-bearing animals treated with AdFlt3L and AdTK, both treatments were statistically different from the saline-treated control group (p < 0.05). Our results demonstrate that combination therapy with AdFlt3L and AdTK can eradicate multifocal brain tumor disease in a syngeneic, intracranial GBM model.
A compact optical transmitter and receiver for 10-Gbit/s transceiver modules (2003)

For wide use of data links, the optical transmitters and. receivers in the transceiver modules must be cost-effective. Miniaturizing is also desirable in order to save space for the transceiver modules, which will reduce costs. We propose cost-effective and compact transmitters and receivers with a simplified optical coupling structure and a mini-DEL sized package. The structure of the optical transmitter is shown. All parts, i.e., the lens, LD, GaAs EA driver IC, and monitor PD, are assembled into a mini-DIL-sized package with a Peltier module. The structure of the optical receiver is similar to that of the transmitter. A lens, pin-PD, pre-amplifier IC, and limiting amplifier IC are integrated in the package. The pre- and limiting amplifiers are fabricated by a SiGe bipolar. process for low power consumption.
Quantitative assessment of villous motility (1987)

A videomicroscopic method was used to quantitatively analyze villous motility in the dog small intestine. The frequency and duration of villous contractions (retractions) were measured in the duodenum, midjejunum, and distal ileum under controlled conditions. A pronounced gradient of villous motility was evident along the bowel. The duodenum exhibited the highest frequency (7.3 +/- 0.1/min) and longest duration (2.6 +/- 0.1 s) of contraction; the jejunum exhibited an intermediate frequency and duration of contraction (4.0 +/- 0.1/min, 2.1 +/- 0.1 s), and the lowest values were measured in the ileum (2.0 +/- 0.1/min and 1.8 +/- 0.1 s). In contrast to the retraction movements, the frequency of pendular villous movements (whipping, swaying movements without shortening) was highest in the jejunum and lowest in the duodenum. The frequency and duration of villous contractions (retractions) remained relatively constant over a 2-h observation period. Reducing mucosal surface temperature from 38 to 30 degrees C caused the frequency of contraction to fall by 33% and the duration to increase by 106%. Varying the suffusate pH within the physiological range of 5.0-7.4 produced no significant effects on jejunal villous motility. Suffusion with glucose (140 and 280 mM) failed to alter villous motility. However, amino acid (15 and 30 mM) and fatty acid (10 mM) solutions significantly increased contraction frequency by 30-50% and 90%, respectively. The videomicroscopic method provides useful quantitative information, which should extend current knowledge regarding the regulation and physiological importance of villous motility.
Unpaired Sentiment-to-Sentiment Translation: A Cycled Reinforcement Learning Approach (2018)

The goal of sentiment-to-sentiment "translation" is to change the underlying sentiment of a sentence while keeping its content. The main challenge is the lack of parallel data. To solve this problem, we propose a cycled reinforcement learning method that enables training on unpaired data by collaboration between a neutralization module and an emotionalization module. We evaluate our approach on two review datasets, Yelp and Amazon. Experimental results show that our approach significantly outperforms the state-of-the-art systems. Especially, the proposed method substantially improves the content preservation performance. The BLEU score is improved from 1.64 to 22.46 and from 0.56 to 14.06 on the two datasets, respectively.
Immunoreactive Renin, Prorenin, and Enzymatically Active Renin in Plasma during Pregnancy and in Women Taking Oral Contraceptives* (1986)

Direct RIA of renin with monoclonal renin antibodies and indirect RIA with angiotensin I antibodies were performed in plasma of 44 pregnant women, 44 women taking an oral contraceptive (OC), and 54 normal women. The following parameters were measured: immunoreactive renin, naturally occurring enzymatically active renin (active renin), trypsin-activatable inactive renin (prorenin), PRA, and renin substrate. Immunoreactive renin (mean, 95% confidence interval) was significantly higher in pregnant women (1090; 420-2800 pg/ml; third trimester) than in normal women (248; 101-562 pg/ml; P less than 0.001) and was lower in OC-treated women (131; 41-415 pg/ml; P less than 0.001). Prorenin and active renin also were increased in pregnant women and decreased in OC-treated women. The fraction of renin that was in the active form was lower in pregnant women (4.8; 1.4-18%) than in OC-treated women (8.8; 3.0-25%; P less than 0.001) and normal women (9.1; 2.9-29%; P less than 0.001). Renin substrate was increased to comparable levels in pregnant women and OC-treated women, but PRA was increased in pregnant women and normal in OC-treated women. The maximum velocity per unit weight of renin was the same for active renal renin as for active plasma renin and trypsin-activated plasma prorenin. Maximum velocity and Km values measured in mixtures of purified active renin and renin substrate and the concentrations of active renin and renin substrate measured in whole plasma were entered into the Michaelis-Menten equation for calculating PRA. The calculated values were similar to the measured results in all three groups, indicating that PRA was determined by the molar concentrations of enzyme and substrate. Thus, we found no evidence of unknown substances in plasma interfering with the enzyme-substrate reaction. The percentage of circulating renin in the active form was much lower during pregnancy than in other conditions where the renal release of active renin is stimulated and prorenin is as high as during pregnancy. This suggests that a smaller fraction of prorenin is intrarenally converted into active renin before its release into the circulation or that a larger fraction of circulating prorenin is of extrarenal origin. The finding that PRA is normal during OC treatment suggests that the estrogen-induced increase in renin substrate is compensated for by suppressed renal release of active renin.
InP-Based High-Speed Transponder (2014)

A new generation of line-side pluggable transponders and transceivers capable of flexible 100 and 200 Gb/s transmission will be underpinned by developments in InP PICs, which offer high performance, compact footprint and low power dissipation.
Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide (2005)

Although chronic inhalation of endotoxin or lipopolysaccharide (LPS) causes all of the classic features of asthma, including airway hyperreactivity, airway inflammation, and airway remodeling, the mechanisms involved in this process are not clearly understood. The objective of this study was to determine whether intratracheal treatment with LPS antagonist (E5564, a lipid A analog) prevented the development of chronic endotoxin-induced airway disease in a mouse model of environmental airway disease. Pretreatment with 10 and 100 microg of E5564 was found to inhibit the airway response (hyperreactivity and inflammation) for up to 48 h after the administration of the compound. Repeated dosing with 50 microg of E5564 intratracheally did not cause any measurable toxicity. Therefore, in a chronic experiment, mice were treated with either E5564 (50 microg) or vehicle three times weekly for 5 wk and simultaneously daily exposed to either LPS (4.65 +/- 0.30 microg/m3) or saline aerosol. E5564 was effective in decreasing the airway hyperreactivity to methacholine, the air space neutrophilia, the interleukin-6 in the lung lavage fluid, and the neutrophil infiltration of the airways 36 h after 5 wk of LPS inhalation. Less collagen deposition was observed in the airways of E5564-treated mice compared with vehicle-treated mice after a 4-wk recovery period. Our results indicate that E5564, a Toll-like receptor 4 antagonist, minimizes the physiological and biological effects of chronic LPS inhalation, suggesting a therapeutic role for competitive LPS antagonists in preventing or reducing endotoxin-induced environmental airway disease.
Subjective and objective measurement of human accommodative amplitude (2003)

Subjective measures of accommodation tend to overestimate true accommodative amplitude. Methods exist to measure accommodation objectively. These include stimulating accommodation with trial lenses or pilocarpine 6% and measuring the accommodative response with an objective optometer such as a Hartinger coincidence refractometer. Objective measures of accommodation should be used to determine whether accommodation can be restored in presbyopes.
Anisotropic etching of InP with low sidewall and surface induced damage in inductively coupled plasma etching using SiCl4 (1997)

We report on the sidewall and surface characterization of InP etched patterns obtained by inductively coupled plasma (ICP). The fabrication of InP based optoelectronic integrated circuits requires dry etching processes, normally using CH4/H2 gas mixtures, with low induced damage, high and reproducible etch rate, and controlled etch direction. These requirements imply the use of a high-density plasma source, which reduces the energy of ions impinging on the wafer surface while keeping a sufficient etch rate. We introduce here the use of an ICP to etch InP. We show that one can obtain anisotropic processes in SiCl4 chemistry avoiding the carrier compensation due to the H+ bombardment. The surface morphology and the pattern profiles are observed by scanning electron microscopy and by atomic force microscopy. Auger electron spectroscopy and secondary ion mass spectroscopy are used to obtain the elemental composition in the top 30 nm of the etched surface and to evaluate contamination. Transmission electron microscopy is used to observe the sidewall damage on patterns delineated by e-beam lithography. The effects of ion density, ion energy, pressure, reactor environment, and surface temperature are observed. Finally, surface damage induced on InP etched substrates are characterized through photoluminescence intensity. We observed the destructive effects of high ion energy etching processes, already reported in CH4/H2 chemistry. Some very low bias voltage processes (as low as 5 V) have been studied in the ICP equipment. It is found that extremely low surface damage and very low sidewall amorphization can be obtained in such processes while keeping high etch rate and anisotropy.
Extracts of electric lobe and electric organ from Torpedo californica increase the total number as well as the number of aggregates of chick myotube acetylcholine receptors (1982)

Saline extracts prepared from the electric lobe, the electromotor nerves, and the electric organ (the electromotor system) of Torpedo californica increase the number of ACh receptors on uninnervated chick myotubes in culture, while extracts from T. californica liver or skeletal muscle do not. The extracts also increase the ACh sensitivity of treated myotubes, indicating that newly synthesized receptors are functional. The active substance(s) is heat sensitive but not trypsin sensitive. Gel filtration on Bio-Gel P-150 shows that the activity is associated with a peak of low (less than 5,000-dalton) molecular weight activity. Labeling studies with rhodamine-conjugated alpha-bungarotoxin show that, in addition to their effect on receptor number, these extracts also cause aggregation of prelabeled ACh receptors on the myotube surface.
Wire arc defect localization and mathematical characterization by MCTDR reflectometry (2017)

This paper demonstrates the feasibility of detecting brief intermittent arcs on wired networks and characterizing them by mathematical modelization. We develop models of reflections generated by arc defects in transmission lines excited by specific test signals, using time-domain reflectometry. Arc fault causes a local modification of the propagation characteristics of the cable. The MCTDR (Multi-carrier Time Domain reflectometry) reflectogram shows the arc as peaks due to impedance change. The location and arc characteristics are automatically calculated and displayed by a computer device. This study provides an accurate assessment of the severity of the arc fault, as the peak amplitude depends heavily on the arc fault impedance, but also on other impedance changes on the cable.
Asymmetric synthesis of α-amino-acid derivatives by alkylation of a chiral Schiff base (1976)

An efficient asymmetric synthesis of D-α-amino-acid derivatives has been achieved by alkylation of a Schiff base prepared from glycine t-butyl ester and (1S,2S,5S)-2-hydroxypinan-3-one.
Monolithic integrated Nd:YAG laser (1990)

By application of the technique of optical contact, a novel type of frequency-stable solid-state laser resonator has been developed. A diode-laser-pumped, monolithic integrated twisted-mode-cavity Nd:YAG laser with 80 mW of single-frequency output power at λ = 1.06 μm has been fabricated. A linewidth below 10 kHz has been measured for the free-running laser.
An ab initio study of the cleavage anisotropy in silicon (2000)

Total-energy pseudopotential calculations are used to study the cleavage fracture processes in silicon. It is shown that bonds break continuously and cracks propagate easily on {111} and {110} planes provided crack propagation proceeds in the 〈1̄10〉 direction. In contrast, if the crack is driven in a 〈001〉 direction on a {110} plane the bond breaking process is discontinuous and associated with pronounced relaxations of the surrounding atoms. The discontinuous process is partly a result of some load sharing between the crack tip bond and the neighbouring bond, which results in a large lattice trapping. The different lattice trapping for different crack propagation directions can explain the experimentally observed cleavage anisotropy in silicon single crystals.
Adult Repellency and Larvicidal Activity of Five Plant Essential Oils Against Mosquitoes (2006)

The larvicidal activity and repellency of 5 plant essential oils--thyme oil, catnip oil, amyris oil, eucalyptus oil, and cinnamon oil--were tested against 3 mosquito species: Aedes albopictus, Ae. aegypti, and Culex pipiens pallens. Larvicidal activity of these essentials oils was evaluated in the laboratory against 4th instars of each of the 3 mosquito species, and amyris oil demonstrated the greatest inhibitory effect with LC50 values in 24 h of 58 microg/ml (LC90 = 72 microg/ml) for Ae. aegypti, 78 microg/ml (LC90 = 130 microg/ml) for Ae. albopictus, and 77 microg/ml (LC90 = 123 microg/ml) for Cx. p. pallens. The topical repellency of these selected essential oils and deet against laboratory-reared female blood-starved Ae. albopictus was examined. Catnip oil seemed to be the most effective and provided 6-h protection at both concentrations tested (23 and 468 microg/ cm2). Thyme oil had the highest effectiveness in repelling this species, but the repellency duration was only 2 h. The applications using these natural product essential oils in mosquito control are discussed.