gebhart/patrepeval huggingface dataset:
Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3 (2007)

We recently showed that overexpression of REIC/Dickkopf-3 (Dkk-3), a tumor suppressor gene, induced apoptosis in a tumor cell-specific manner. The aim of the present study was to determine the mechanisms underlying the selective induction of apoptosis. At first, we found a mouse renal carcinoma cell line, RENCA, to be extremely sensitive to an adenovirus carrying REIC/Dkk-3 (Ad-REIC), and we showed that activation of c-Jun N-terminal kinase (JNK) was a critical step in cell death, i.e. a process similar to that in human prostate and testicular cancer observed in our previous studies. Among the proteins interfering with the activation of JNK, heat shock protein (Hsp)70/72 was reduced in expression in RENCA cells compared with that in NIH3T3 cells. An Hsp70/72 inducer protected RENCA cells from Ad-REIC-induced apoptosis, while an Hsp70/72 inhibitor sensitized NIH3T3 cells for apoptosis induction. These results indicate that functionally active Hsp70/72 is a key factor in tumor cell-specific induction of apoptotic cell death and that analyses of the expression levels of Hsp70/72 may be essential in determining the significance of Ad-REIC-based gene therapy against human cancer.
Coherent-pulse implementations of quantum cryptography protocols resistant to photon-number-splitting attacks (2004)

We propose a class of quantum cryptography protocols that are robust against photon-number-splitting attacks (PNS) in a weak coherent-pulse implementation. We give a quite exhaustive analysis of several eavesdropping attacks on these schemes. The honest parties (Alice and Bob) use present-day technology, in particular an attenuated laser as an approximation of a single-photon source. The idea of the protocols is to exploit the nonorthogonality of quantum states to decrease the information accessible to Eve due to the multiphoton pulses produced by the imperfect source. The distance at which the key distribution becomes insecure due to the PNS attack is significantly increased compared to the existing schemes. We also show that strong-pulse implementations, where a strong pulse is included as a reference, allow for key distribution robust against photon-number-splitting attacks.
Android: Static Analysis Using Similarity Distance (2012)

As Android applications become increasingly ubiquitous, we need algorithms and tools to protect applications from product tampering and piracy, while facilitating valid product updates. Since it is easy to derive Java source code from Android byte code, Android applications are particularly vulnerable to tampering. This paper presents an algorithm, based on a customized similarity distance, which returns a value between 0 and 1, which can serve as a change indicator. Potential applications of the algorithm include 1) to determine if obfuscators, applied by developers, are protecting their code from piracy, 2) to determine if an Android application is infected with malware, facilitating the automatic extraction of the injected malware, and 3) to identify valid code updates and releases as part of the code release cycle.
Use of Organic Acids as a Model to Study the Impact of Gut Microflora on Nutrition and Metabolism (2002)

Approvals for the use of nontherapeutic antibiotics in animal feed are fast disappearing worldwide. The primary effect of antibiotics is antimicrobial; all of the digestibility and performance effects can by explained by their impact on the gastrointestinal microflora. Among the candidate replacements for antibiotics are organic acids, both individual acids and blends of several acids. Like antibiotics, short-chain organic acids also have a specific antimicrobial activity. Unlike antibiotics, the antimicrobial activity of organic acids is pH dependent. Organic acids have a clear and significant benefit in weanling piglets and have been observed to benefit poultry performance. Organic acids have antimicrobial activity; however, there appear to be effects of organic acids beyond those attributed to antimicrobial activity. Reductions in bacteria are associated with feeding organic acids, which are particularly effective against acid-intolerant species such as E. coli, Salmonella and Campylobacter. Both antibiotics and organic acids improve protein and energy digestibilities by reducing microbial competition with the host for nutrients and endogenous nitrogen losses, by lowering the incidence of subclinical infections and secretion of immune mediators, and by reducing production of ammonia and other growth-depressing microbial metabolites. Organic acids have several additional effects that go beyond those of antibiotics. These include reduction in digesta pH, increased pancreatic secretion, and trophic effects on the gastrointestinal mucosa. Much more is known about these effects in swine than in poultry. There appears to be more variability in detecting an organic acid benefit in comparison to that observed with antibiotics. Lack of consistency in demonstrating an organic acid benefit is related to uncontrolled variables such as buffering capacity of dietary ingredients, presence of other antimicrobial compounds, cleanliness of the production environment, and heterogeneity of gut microbiota. Additional research can clarify the role of these factors and how to minimize their impact.
Front Matter and Table of Contents (1985)

This entry contains the front cover, front matter and back cover.
Mitochondrial Hydroxyproline Metabolism: Implications for Primary Hyperoxaluria (2005)

These results indicate that studies on isolated mitochondria have the potential to help unravel the metabolism associated with glyoxylate and oxalate production and understand the metabolic function of glyoxylate reductase.
Quantitative Stereological Analysis of Grain Bonds in Snow (1975)

A section-plane preparation technique and an operational definition of a snow grain bond are developed to allow the quantitative analysis of bonding in snow structure. Values for three-dimensional grain size, grain-bond size and number density, and related bonding measurements are presented for equi-temperature metamorphosed snow. These results from mutually orthogonal planes within a given snow block show that the assumptions of randomness and isotropy of grain and grain-bond location and orientation, necessary for stereological analysis from one plane, are satisfied to within ± 10% even after 30% uniaxial plastic deformation of the snow block. The idealization of a grain bond as a circular plane disk yields self-consistent results. The number of bonds per grain cannot be accurately determined from two-dimensional studies due to variations in the shape and size of snow grains within a given sample.
Gap junctions and fluid flow response in MC3T3-E1 cells (2001)

In the current study, we examined the role of gap junctions in oscillatory fluid flow-induced changes in intracellular Ca(2+) concentration and prostaglandin release in osteoblastic cells. This work was completed in MC3T3-E1 cells with intact gap junctional communication as well as in MC3T3-E1 cells rendered communication deficient through expression of a dominant-negative connexin. Our results demonstrate that MC3T3-E1 cells with intact gap junctions respond to oscillatory fluid flow with significant increases in prostaglandin E(2) (PGE(2)) release, whereas cells with diminished gap junctional communication do not. Furthermore, we found that cytosolic Ca(2+) (Ca) response was unaltered by the disruption in gap junctional communication and was not significantly different among the cell lines. Thus our results suggest that gap junctions contribute to the PGE(2) but not to the Ca response to oscillatory fluid flow. These findings implicate gap junctional intercellular communication (GJIC) in bone cell ensemble responsiveness to oscillatory fluid flow and suggest that gap junctions and GJIC play a pivotal role in mechanotransduction mechanisms in bone.
Phylogenetic analysis of<i>Bacillus sphaericus</i>and development of an oligonucleotide probe specific for mosquito-pathogenic strains (1993)

The 16S rRNA gene sequences for six strains of Bacillus sphaericus representing five distinct DNA homology groups and one strain of Bacillus fusiformis have been determined. An-oligonucleotide probe based on the area approximately between position 186 and 198 (Escherichia coli numbering) of the 16S rRNA gene of the mosquito pathogen, strain 2362, hybridised to DNA from strains of DNA homology group IIA which contains all known mosquito pathogens and not to any of ten other Bacillus species. It can be used to identify potential mosquito-pathogenic strains of B. sphaericus in screening programmes.
Melatonin: Pharmacology, Functions and Therapeutic Benefits (2017)

This review highlights the high number and diversity of major melatonin effects and opens important perspectives for measuring melatonin as a biomarker (biomarker of early identification of certain disorders and also biomarker of their follow-up) and using melatonin with clinical preventive and therapeutic applications in newborns, children and adults based on its physiological regulatory effects.
Increased nuclear DNA content in developing cotton fiber cells (1999)

The nuclear DNA content of developing cotton fiber cells (Gossypium hirsutum, cv. MD51ne) increases ∼24% after 2 d postanthesis (dpa). The amount of nuclear DNA at 2 dpa is 5.4 ± 0.27 pg. At 3-4 dpa it increases to 6.7 ± 0.24 pg and by 5 dpa it is 6.8 ± 0.70 pg. These values were obtained by nuclear fluorescence after staining with Hoechst 33258. Human oral squamous cell nuclei were used as a DNA standard. Nuclear DNA content increases in fibers growing on either fertilized or unfertilized ovules. The increase also is detectable in Feulgen stained nuclei using two-wavelength cytospectrophotometry. All measurements were made on isolated fiber cell nuclei using a newly developed method tailored to cotton fiber cells. The results imply that during the early stages of development fiber cell nuclei either selectively amplify certain sequences or enter S-phase replicating a portion of their genome.
A Two-Level Programming Model Based on Spreadsheet and Data Flow Chart (2010)

This paper proposes a two-level programming model based on spreadsheet and data flow chart for end-user programming, which adopts spreadsheet-based top-down construction pattern and dataflow-based bottom-up modification pattern to compose mashup applications. The model can not only provide users with spreadsheet-like programming style, but also provide flexible modification operators for mashups to reduce the complexity of composing mashup applications.
Treadmill motor current value based walk phase estimation (2009)

We have developed a gait rehabilitation robot for hemiplegic patients using the treadmill. A walk phase, which includes time balance of stance and swing legs, is one of the most basic indexes to evaluate patients' gait. In addition, the walking phase is one of the indexes to control our robotic rehabilitation system. However, conventional methods to measure the walk phase require another system such as the foot switch and force plate. In this paper, an original algorithm to estimate the walk phase of a person on a treadmill using only the current value of DC motor to control the treadmill velocity is proposed. This algorithm was verified by experiments on five healthy subjects, and the walk phase of four subjects could be estimated in 0.2 (s) errors. However, the algorithm had erroneously identified a period of time in the stance phase as swing phase time when little body weight loaded on the subject's leg. Because a period of time with little body weight to affected leg is often observed in a hemiplegic walk, the proposed algorithm might fail to properly estimate the walk phase of hemiplegic patients. However, this algorithm could be used to estimate the time when body weight is loaded on patient legs, and thus could be used as a new quantitative evaluation index.
Field programmable thermal emulator (FPTE): An all-silicon test structure for thermal characterization of integrated circuits (2014)

This paper presents an on-chip digitally programmable test structure, referred to as the field programmable thermal emulator (FPTE), for on-line characterization of power pattern, time-varying thermal field, and associated changes in the electrical characteristics of the transistors. A test chip was designed in 130nm CMOS to validate the test structure. The measurement results demonstrated the ability of FPTE to emulate various power patterns and capture the effects on temperature and circuit performance.
Covalent intermediate trapped in 2-keto-3-deoxy-6- phosphogluconate (KDPG) aldolase structure at 1.95-Å resolution (2001)

2-Keto-3-deoxy-6-phosphogluconate (KDPG) aldolase catalyzes the reversible cleavage of KDPG to pyruvate and glyceraldehyde-3-phosphate. The enzyme is a class I aldolase whose reaction mechanism involves formation of Schiff base intermediates between Lys-133 and a keto substrate. A covalent adduct was trapped by flash freezing KDPG aldolase crystals soaked with 10 mM pyruvate in acidic conditions at pH 4.6. Structure determination to 1.95-A resolution showed that pyruvate had undergone nucleophilic attack with Lys-133, forming a protonated carbinolamine intermediate, a functional Schiff base precursor, which was stabilized by hydrogen bonding with active site residues. Carbinolamine interaction with Glu-45 indicates general base catalysis of several rate steps. Stereospecific addition is ensured by aromatic interaction of Phe-135 with the pyruvate methyl group. In the native structure, Lys-133 donates all of its hydrogen bonds, indicating the presence of an epsilon-ammonium salt group. Nucleophilic activation is postulated to occur by proton transfer in the monoprotonated zwitterionic pair (Glu-45/Lys-133). Formation of the zwitterionic pair requires prior side chain rearrangement by protonated Lys-133 to displace a water molecule, hydrogen bonded to the zwitterionic residues.
Phase I study of temozolomide and escalating doses of oral etoposide for adults with recurrent malignant glioma (2003)

Abstract BACKGROUND Although temozolomide is active against recurrent malignant glioma, responses in many patients are modest and short‐lived. Temozolomide may prove more effective in combination with other agents. Therefore, combination oral chemotherapy for these patients is a particularly attractive approach. METHODS The authors conducted a Phase I study of temozolomide in combination with escalating doses of oral etoposide (VP‐16) to determine the maximum tolerated doses of these two agents when given together. The temozolomide dose was fixed at 150 mg/m 2 per day on Days 1–5. The oral VP‐16 was escalated in cohorts of 3 to 6 patients by numbers of days of VP‐16 administered: 50 mg/m 2 per day, Days 1–5 (dose level 1), Days 1–8 (dose level 2), Days 1–12 (dose level 3), Days 1–16 (dose level 4), and Days 1–20 (dose level 5). Therapy was given in 28‐day cycles. RESULTS Of the 29 patients enrolled, 26 were fully evaluable and 3 were partially evaluable for toxicity. The 29 patients received a total of 92 cycles. The median age of the patients was 49 years (range, 28–76 years). Diagnoses included glioblastoma ( n = 19), gliosarcoma ( n = 3), anaplastic astrocytoma ( n = 5), and anaplastic oligoastrocytoma ( n = 2). The median time from diagnosis to disease recurrence was 8 months (3–188 months). Twenty patients were treated at the first disease recurrence, seven at the second, and two at the third. Twenty‐four patients (83%) were receiving anticonvulsants and 24 were receiving dexamethasone. All patients had received previous radiation, and 25 of 29 had been treated with chemotherapy previously. Of the 3 patients at dose level 1, none had dose‐limiting toxicity (DLT). Of the 6 patients at dose level 2, 1 patient had DLT: Grade 3 thrombocytopenia resulting in a > 2‐week delay in starting the next cycle of chemotherapy. Of the 6 patients at dose level 3, 1 patient had DLT: death due to pneumonia. There were 2 DLTs in the 7 patients at dose level 4: fever, neutropenia, and herpes zoster infection in 1 patient and death due to pneumonia in another. Seven patients had been started at dose level 5 when DLT was established at dose level 4: of the 5 fully evaluable and 2 partially evaluable patients at dose level 5, there was no DLT. CONCLUSIONS The maximum tolerated dose of temozolomide and oral VP‐16 in this heavily treated group of patients with recurrent malignant glioma is temozolomide 150 mg/m 2 per day for 5 days and oral VP‐16 50 mg/m 2 per day for 12 days. Cancer 2003;97:1963–8. © 2003 American Cancer Society. DOI 10.1002/cncr.11260
A 4-Channel UWB Beam-Former in 0.13&#x003BC;m CMOS using a Path-Sharing True-Time-Delay Architecture (2007)

A fully integrated 4-channel UWB beam-former in 0.13μm CMOS uses a path-sharing true-time-delay architecture with 15ps resolution. The 3.1×3.2mm <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> chip produces 11 different scanning angles within plusmn60deg with 10° spatial resolution for 25mm antenna spacing. The front-end achieves an NF of 2.9 to 4.8dB across 18GHz of BW with less than 5ps of group delay variation.
Crying in separated and non‐separated newborns: sound spectrographic analysis (1996)

During the first 1-2 h after birth crying occurs during separation from the mother and stops on reunion. In rats, such "separation distress calls" have distinct phonetic properties. We examined this early crying by sound spectrography in 29 healthy, full-term, vaginally delivered babies, randomly assigned either to be kept in a cot or to be placed in body contact with the mother during the 90 min following birth. The former babies cried almost 10 times more than the latter ones. The duration of the cry signal (the smallest element of a cry analysed by spectrography) in both groups was 0.8-09s; the melody contour was flat or slightly rising--falling with a fundamental frequency of around 500 hertz. The cry is provisionally characterized as a discomfort cry, elicited mainly by separation from the mother.
Modeling Call Quality for Time-Varying Transmission Characteristics Using Simulated Conversational Structures (2009)

This study investigates the perception of speech quality over telephone channels with time-varying transmission characteristics for simulated conversational structures. The aim is to establish a relationship between subjective quality associated with short speech samples (5―6 seconds) and quality associated with overall conversations (1― 2 minutes). Two two-part experiments were conducted. In the first part of each experiment, dialog-final ratings within the temporal structure of a telephone conversation were assessed. Varying transmission characteristics were realized with ten different degradation profiles of preprocessed speech samples obtained mainly from real mobile channels to ensure authentic types of degradation. The second part was carried out to obtain separate short-term ratings of the speech samples used in the first part. Experiments 1 and 2 tested different conversation durations (1 and 2 minutes). The results demonstrate that dialog-final ratings vary with respect to the degradation profile, revealing a recency effect and a strong impact of individual bad samples. Two related models which implement these findings are presented. With these models, dialog-final quality ratings can be estimated significantly better than by plain averaging of short sample ratings (about 10% absolute improvement). They also perform better than two algorithms taken from literature. Both models can be applied to the instrumental method described in ITU-T Rec. P.862 [1], resulting in about 13% absolute improvement. They were evaluated with the results of two different experiments, which were performed independently but on the basis of our test procedure. In these experiments similar profiles but a different type of quality degradation, different sample durations, and different speech material were used. The models proved to be valid and reliable for the time span investigated (1―2 minutes) and for the profiles used. One of them is now being recommended by the ETSI STQ mobile group.
Three Chloro(trifluoromethyl)pyridines as Model Substrates for Regioexhaustive Functionalization (2004)

Abstract As a further test of the concept of regioexhaustive functionalization, 2‐chloro‐6‐(trifluoromethyl)pyridine, 2‐chloro‐5‐(trifluoromethyl)pyridine and 3‐chloro‐4‐(trifluoromethyl)pyridine were each converted into the three possible carboxylic acids 2, 4, 6, 8 , 10, 12 , 16, 17 and 20 . This was achieved by employing several, but not all of the organometallic “toolbox methods”: transformation of a more basic organometallic species into a less basic isomer by transmetalation‐equilibration, site discriminating deprotonation with lithium N , N ‐diisopropylamide or lithium 2,2,6,6‐tetramethylpiperidide, regio‐divergent iodine migration and steric screening of acidic positions by a bulky trialkylsilyl group. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Current sensing IGBT structure with improved accuracy (2002)

A current sensing IGBT structure has been investigated in order to reduce collector-emitter voltage dependence of the sensing current ratio to the main IGBT current for short-circuit over-current protection. The operation physics of the current sensing IGBT during short-circuit was analyzed by numerical simulation and experimental results of the improved performance of the current sensing IGBT are presented.
Shared device driver model for virtualized mobile handsets (2008)

One of the major expected benefits of hardware virtualization in mobile handsets is the ability to use a peripheral device, for which an original device driver has been written for a particular operating system, from applications running on other operating systems. The savings and new opportunities generated by avoiding writing multiple device drivers for the same peripheral because for different operating systems (Symbian, Windows, Linux, and proprietary real-time operating systems) are tremendous, and relevant to the whole eco-system (chipset and hardware peripheral vendors, device manufacturers, Independent Software Vendors (ISVs), service providers and even end-users.
Impact of the vertical SOI 'DELTA' structure on planar device technology (1991)

A fully depleted lean channel transistor (DELTA) with its gate incorporated into a new vertical ultrathin silicon-on-insulator (SOI) structure is presented. In the deep-submicrometer region, selective oxidation produces and isolates an ultrathin SOI MOSFET that has high crystalline quality, as good as that of conventional bulk single-crystal devices. Experiments and three-dimensional simulations have shown that this new gate structure has effective channel control and that the vertical ultrathin SOI structure provides superior device characteristics: reduction in short-channel effects, minimized subthreshold swing, and high transconductance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>