gebhart/patrepeval huggingface dataset:
Sterically Stabilized Anti-HER2 Immunoliposomes:  Design and Targeting to Human Breast Cancer Cells <i>in Vitro</i> (1997)

Liposomes (70-100 nm) of 1-palmitoyl-2-oleoylphosphatidylcholine, cholesterol, and poly(ethylene glycol) (PEG)-modified phosphatidylethanolamine (PEG-DSPE) were conjugated to Fab' fragments of a humanized recombinant MAb against the extracellular domain of HER2/neu to create sterically stabilized immunoliposomes (anti-HER2 SL) as a drug carrier targeting HER2-overexpressing cancers. Conjugation employed maleimide-terminated membrane-anchored spacers of two kinds: a short spacer, providing attachment of Fab' close to the liposome bilayer, or a long spacer, with Fab' attachment at the distal terminus of the PEG chain. Confocal microscopy and spectrofluorometry of HER2-overexpressing breast cancer cells incubated with fluorescently labeled anti-HER2 SL prepared with either spacer showed binding of liposomes (8000-23000 vesicles/cell) followed by endocytosis (rate constant ke = 0.012-0.033 min-1) via the coated-pit pathway, evidenced by intracellular acidification and colocalization with transferrin. Uptake of anti-HER2 immunoliposomes by breast cancer cells with low HER2 expression, or after preincubation of cells with free anti-HER2 Fab', was less than 0.2% and 4.3%, respectively, of the uptake by HER2-overexpressing cells. Increasing PEG-DSPE content (up to 5.7 mol %) in anti-HER2-SL prepared with the short spacer decreased liposome-cell binding affinity 60-100-fold, while ke decreased only 2-fold; however, when Fab' fragments were conjugated via a PEG spacer, both binding affinity and ke were unaffected by PEG-DSPE content. Cell binding and internalization of anti-HER2 immunoliposomes increased at higher surface density of conjugated Fab' fragments, reaching plateaus at approximately 40 Fab'/liposome for binding and approximately 10-15 Fab'/liposome for internalization. Uptake of anti-HER2 immunoliposomes correlated with the cell surface density of HER2 and significantly (p < 0.005) correlated with the antiproliferative effect of the targeting antibody but not with the total level of cellular HER2 expression. The results obtained were used to optimize in vivo preclinical studies of anti-HER2 SL loaded with antineoplastic drugs.
Dynamic Hybrid Strategy Models for Networked Mulitplayer Games (2005)

Two of the primary factors in the development of\nnetworked multiplayer computer games are network\nlatency and network bandwidth. Reducing the effects of\nnetwork latency helps maintain game-state fidelity,\nwhile reducing network bandwidth usage increases the\nscalability of the game to support more players. The\ncurrent technique to address these issues is to have each\nplayer locally simulate remote objects (e.g. other\nplayers). This is known as dead reckoning. Provided the\nlocal simulations are accurate to within a given\ntolerance, dead reckoning reduces the amount of\ninformation required to be transmitted between players.\nThis paper presents an extension to the recently\nproposed Hybrid Strategy Model (HSM) technique,\nknown as the Dynamic Hybrid Strategy Model\n(DHSM). By dynamically switching between models of\nuser behaviour, the DHSM attempts to improve the\nprediction capability of the local simulations, allowing\nthem to stay within a given tolerance for a longer\namount of time. This can lead to further reductions in\nthe amount of information required to be transmitted.\nPresented results for the case of a simple first-person\nshooter (FPS) game demonstrate the validity of the\nDHSM approach over dead reckoning, leading to a\nreduction in the number of state update packets sent and\nindicating significant potential for network traffic\nreduction in various multiplayer games/simulations.
Robust Audio Fingerprinting Method Using Prominent Peak Pair Based on Modulated Complex Lapped Transform (2014)

The robustness of an audio fingerprinting system in an actual noisy environment is a major challenge for audio-based content identification. This paper proposes a high-performance audio fingerprint extraction method for use in portable consumer devices. In the proposed method, a salient audio peak-pair fingerprint, based on a modulated complex lapped transform, improves the accuracy of the audio fingerprinting system in actual noisy environments with low computational complexity. Experimental results confirm that the proposed method is quite robust in different noise conditions and achieves promising preliminary accuracy results.
Software support for heterogeneous computing (1996)

article Free Access Share on Software support for heterogeneous computing Authors: Howard Jay Siegel Purdue University, West Lafayette, Indiana Purdue University, West Lafayette, IndianaView Profile , Henry G. Dietz Purdue University, West Lafayette, Indiana Purdue University, West Lafayette, IndianaView Profile , John K. Antonio Texas Tech University, Lubbock Texas Tech University, LubbockView Profile Authors Info & Claims ACM Computing SurveysVolume 28Issue 1March 1996 pp 237–239https://doi.org/10.1145/234313.234411Published:01 March 1996Publication History 21citation711DownloadsMetricsTotal Citations21Total Downloads711Last 12 Months67Last 6 weeks17 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Stable Single-Crystalline Body Centered Cubic Fe Nanoparticles (2011)

We report a facile synthesis of body centered cubic (bcc) Fe nanoparticles (NPs) via the thermal decomposition of iron pentacarbonyl, Fe(CO)(5), in the presence of hexadecylammonium chloride. These bcc-Fe NPs exhibit a drastically increased stability and magnetic moment (M(s) = 164 A·m(2)·kg(-1)(Fe)) even in physiological solutions, and have much enhanced magnetic imaging contrast (r(2) = 220 s(-1)·mM(-1)) and heating (SAR = 140 W·g(-1)(Fe)) effects. They may serve as robust probes for imaging and therapeutic applications.
Ultralow-Power Ku-Band Dual-Feedback Armstrong VCO With a Wide Tuning Range (2012)

Here, we investigate the design of a Ku-band Armstrong voltage-controlled oscillator (VCO) utilizing dual transformer feedback for low-voltage low-power operation. The primary transformer feedback between the drain and the source of the VCO increases the output voltage swing under low supply voltage. With the secondary transformer feedback, g_m-boosting is obtained by the coupling between the drain and the gate of the Armstrong VCO. Combined with transformer feedback, g_m-boosting further reduces the negative transconductance required for oscillation startup, enabling ultralow-power operation. Thus, the proposed Armstrong VCO with dual feedback operates at 0.4 V with power consumption as low as 600 W. Under this condition, the measured phase noise of the VCO is -100.6 dB/Hz at 1-MHz offset from a 14.1-GHz carrier. The results show that the proposed VCO is suitable for very low-power applications requiring high signal purity.
Pesticidal Activities of Some Cyclic Phosphorus Esters (1962)

Preliminary tests for pesticidal activities of some cyclic phosphorus esters derived from o-hydroxybenzyl alcohol or its analogues were undertaken. 2-Ethoxy-4H-l,3,2-benzodioxa-phosphoran-2-one has strong insecticidal activity. Some other esters have weak or no insecti-cidal activity by themselves but strong synergistic action with malathion to houseflies and silkworms. Some cyclic esters show nematocidal activity and phytotoxicity.
Phase Equilibrium Compositions, Densities, and Viscosities of Aqueous Two-Phase Poly(ethylene glycol) + Poly(acrylic acid) System at Various Temperatures (2006)

The effect of temperature on the densities and viscosities of aqueous solution of poly(acrylic acid) (PAA) of different mass fraction (from 0.05 to 0.50) and liquid−liquid equilibrium, densities, and viscosities for the aqueous two-phase PEG-6000 + PAA + water system at equilibrium have been measured. The densities and viscosities of the PAA + water system at different temperatures were correlated as a function of mass fraction. The binodal curves for the PEG + PAA + water system have been correlated using a four-parameter equation. The increase in temperature results in an increase in the two-phase region. The tie line compositions have been fitted to both the Othmer−Tobias and the Bancroft equations. A linear dependency of both the plots indicates the consistency of the data; however, the Bancroft equation gives the best fit.
Substitution of Cotton Cytoplasms from Wild Diploid Species for Cotton Germplasm Improvement<sup>1</sup> (1985)

The purpose of this investigation was to initiate a program of cytoplasm introgression from the wild diploid species into cultivated cotton ( Gossypium hirsutum L.) and then use the semigametic trait of Pima cotton ( G. barbadense L.) to develop homozygous cytoplasmic‐substituted lines for evaluation and commercial release. It was determined that the in situ pattern of ovule and embryo growth in the wild species is similar to the cultigens but that the wild relatives have a shortened period of boll development, show reduced seed size and weight, have fewer seeds per boll, and in some cases require specific light conditions in order to initiate flowering. Three new interspecific hybrids with wild species cytoplasms were recovered by using four different pollen parent sources, a single application of GA 3 , at 3.5 mmol L −1 to the flower at anthesis, and embryo rescue techniques. Results indicated that the success of fertilization and embryo development was strongly influenced by the paternal species used to make the cross, and secondly, that the degree of hybrid embryo development may be a more important factor than the age or size at the time of embryo rescue. Immature embryos rescued prior to 15 days post‐anthesis failed to show further development or undergo precocious germination. The optimum time for embryo rescue and recovery occurred between 15 and 25 days after anthesis. Cytogenetic analysis of the hybrids verified that they were true interspecies crosses. Observations of meiotic metaphase chromosomes indicated the degree of relatedness between species. As expected, chromosome pairing indicated a very close homoeology between the G. trilobum DC. ex Skov. (D 8 ) genome and the D subgenome of G. hirsutum . The E genomes of G. stocksii Mast ex Hook. (E 1 ) and G. somalense (Gürke) Mayer (E 2 ) exhibited little homoeology to either the A or the D subgenome of G. hirsutum or the A genome of G. arboreum L. Cytogenetic observations by others on the reciprocal hybrids of these species closely agree with our data on chromosome associations. Thus, there does not appear to be a significant effect of cytoplasm on chromosome pairing in the primary hybrids.
Laser-assisted cell removing (LACR) technology contributes to the purification process of the undifferentiated cell fraction during pluripotent stem cell culture (2018)

Purification of undifferentiated cells by removing differentiated parts is an essential step in pluripotent stem cell culture. This process has been traditionally performed manually using a fine glass capillary or plastic tip under a microscope, or by culturing in a selective medium supplemented with anti-differentiation inhibitors. However, there are several inevitable problems associated with these methods, such as contamination or biological side-effects. Here, we developed a laser-assisted cell removing (LACR) technology that enables precise, fast, and contact-less cell removal. Using LACR combined with computational image recognition/identification-discriminating technology, we achieved automatic cell purification (A-LACR). Practicability of A-LACR was evaluated by two demonstrations: selective removal of trophoblast stem (TS) cells from human iPS and TS cell co-cultures, and purification of undifferentiated iPS cells by targeting differentiated cells that spontaneously developed. Our results suggested that LACR technology is a novel approach for stem cell processing in regenerative medicine.
Optical Properties of the Alpha-Phase Alloys Ag-Zn and Ag-Cd (1970)

Reflectance measurements at near-normal incidence have been performed on chemically polished, annealed, polycrystalline samples of Ag-Zn and Ag-Cd alloys. Data were obtained for Ag and Ag-Zn and Ag-Cd alloy samples with 2.5, 5.0, 10.0, 20.0, and 30.0% $\mathrm{II}B$ atom concentrations. The measurements were made with a precision of 2% of measured reflectance over a spectrum 1.2-13.5 eV at temperatures of 110, 295, and 400 \ifmmode^\circ\else\textdegree\fi{}K. Dielectric constants were computed by the Kramers-Kronig method. Trends of the dielectric constants with either a Zn or Cd concentration are basically similar. The principal ${\ensuremath{\epsilon}}_{2}$ peak of Ag at 4.0 eV moves to higher energies with an increase of $\mathrm{II}B$ atom concentration; however, a secondary peak, observed only in the alloys, moves to lower energies. Transitions probably occur in the alloys from the $d$ band to the Fermi surface and also from the Fermi surface to the $s$ band. The transition to the Fermi surface is dominant in Ag. Trends of the ${\ensuremath{\epsilon}}_{2}$ peaks for alloys with a concentration of Zn or Cd follow an approximate free-electron model. Energy gaps in Ag deduced from the present data are in approximate agreement with the deductions of Berglund and Spicer from photoemission experiments. Marked differences exist between the Ag-Zn and the Ag-Cd alloys. The dilute (2.5%) Ag-Zn alloy has a distinctly sharper ${\ensuremath{\epsilon}}_{2}$ edge than the corresponding Ag-Cd alloy. On the other hand, the low-energy absorption peak is seen first in the Ag-Cd alloy. These observations suggest that in the Ag-Zn alloy the additional electron contributed by the Zn tends to remain localized, whereas in the Ag-Cd alloy, it tends to contribute to the total number of free electrons and thereby increases the probability of transition to the $s$ band. At 10% or higher concentrations, the optical characteristics are less sharply defined and the temperature effects are weaker for the Ag-Zn alloy than for the Ag-Cd alloy.
Thermal Ring‐Opening Polymerization of Hydrocarbon‐Bridged [2]Ferrocenophanes: Synthesis and Properties of Poly(ferrocenylethylene)s and Their Charge‐Transfer Polymer Salts with Tetracyanoethylene (1997)

Abstract The poly(ferrocenylethylene)s [Fe(η‐C 5 H 3 RCH 2 ) 2 ] n 5a and 5b ( a : R = H, b : R = Me) have been prepared by thermal ring‐opening polymerization of the corresponding strained hydrocarbon‐bridged [2]ferrocenophanes [Fe(η‐C 5 ‐H 3 RCH 2 ) 2 ] ( 4a and 4b ). An X‐ray diffraction study of 4a indicated significant strain. Polymer 5a was crystalline and insoluble in common organic solvents and was characterized by solid‐state 13 C NMR. Polymer 5b , which was soluble in organic solvents, was characterized by 1 H and 13 C NMR, UV/visible spectroscopy and elemental analysis. Its molecular weight distribution was bimodal (gel permeation chromatography: M w = 9.6 × 10 4 , M n = 8.6 × 10 4 for the high molecular weight fraction, M w = 4.8 × 10 3 , M n = 3.5 × 10 3 for the oligomeric fraction), suggesting two polymerization mechanisms. The UV/visible spectrum implied a localized structure for the polymer backbone. Cyclic voltammetry revealed that 5b undergoes two reversible oxidations in CH 2 Cl 2 solution at–0.25 and–0.16V. The redox coupling is indicative of only a small degree of interaction between the iron centres. Thermogravimetric analysis indicated that 5a and 5b are thermally stable to ca. 300–350°C under N 2 . At higher temperatures they yield ferromagnetic iron carbide ceramics 6a and 6b (ca. 50% and 32%, respectively, at 600°C) together with molecular depolymerization products. The reaction of 5b with tetracyanoethylene (TCNE) yielded insoluble and soluble oxidized products 11 and 12 , which differed in the degree of oligomerization of the TCNE y‐ x counterions. These products were characterized by IR, elemental analysis, ESR spectroscopy, and magnetic susceptibility measurements. The last revealed the presence of significant antiferromagnetic interactions in 12 .
Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS (2013)

This study aims at substituting the essential functions of photoreceptors in patients who are blind owing to untreatable forms of hereditary retinal degenerations. A microelectronic neuroprosthetic device, powered via transdermal inductive transmission, carrying 1500 independent microphotodiode-amplifier-electrode elements on a 9 mm(2) chip, was subretinally implanted in nine blind patients. Light perception (8/9), light localization (7/9), motion detection (5/9, angular speed up to 35 deg s(-1)), grating acuity measurement (6/9, up to 3.3 cycles per degree) and visual acuity measurement with Landolt C-rings (2/9) up to Snellen visual acuity of 20/546 (corresponding to decimal 0.037° or corresponding to 1.43 logMAR (minimum angle of resolution)) were restored via the subretinal implant. Additionally, the identification, localization and discrimination of objects improved significantly (n = 8; p < 0.05 for each subtest) in repeated tests over a nine-month period. Three subjects were able to read letters spontaneously and one subject was able to read letters after training in an alternative-force choice test. Five subjects reported implant-mediated visual perceptions in daily life within a field of 15° of visual angle. Control tests were performed each time with the implant's power source switched off. These data show that subretinal implants can restore visual functions that are useful for daily life.
Fully Batch Fabricated Magnetic Microactuators Using A Two Layer Liga Process (2005)

Full batch fabrication and successful testing of electromagnetic linear actuators is demonstrated. The fabrication uses a 5 mask process that combines two deep x-ray lithography layers and 3 optical lithography layers. Material magnetic properties have been investigated and the relative permeability of nickel was found to be 12 while that of nickel/iron permalloy was 400. Design rules are derived for the case of a microrelay where large forces at small gaps are required. Switching of relays was observed at 1.4 A for a relay made out of nickel and at 45 mA for one of permalloy. Particularly for permalloy, the contact forces at 1A are well beyond those of miniaturised relays.
Perchloric Acid Isomerization of Oleic Acid (1968)

ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTPerchloric Acid Isomerization of Oleic AcidJohn Showell, Daniel Swern, and Wilfred NobleCite this: J. Org. Chem. 1968, 33, 7, 2697–2704Publication Date (Print):July 1, 1968Publication History Published online1 May 1968Published inissue 1 July 1968https://pubs.acs.org/doi/10.1021/jo01271a018https://doi.org/10.1021/jo01271a018research-articleACS PublicationsCopyright © 1968 American Chemical SocietyRequest reuse permissionsArticle Views341Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Associações entre medidas de Funções Executivas e sintomas de desatenção e hiperatividade em crianças em idade escolar (2014)

"Estudos têm demonstrado que alterações nas funções executivas tendem a ser os maiores complicadores para o diagnóstico de TDAH. Essa pesquisa investigou associações entre medidas de funções executivas e de TDAH em 254 crianças, sendo 124 com sintomas de TDAH, de acordo com o SNAP IV, de 6 a 12 anos que frequentavam escolas públicas no interior do estado de São Paulo (Brasil). Foram administrados os testes dos Cinco Pontos, Cancelamento, Trilhas forma B, Números e Dígitos que avaliavam atenção, flexibilidade cognitiva e controle inibitório e o SNAP-IV. Dentre os resultados, foram encontradas correlações negativas entre as medidas de funções executivas avaliadas e a incidência de sintomas do TDAH. A análise de regressão revelou que a pontuação total do teste de cinco pontos menos os desenhos únicos foi a que melhor explicou sintomas de desatenção. Os sintomas de hiperatividade não foram explicados por nenhuma das medidas de funções executivas estudadas no modelo de regressão. Tais resultados sugerem que a avaliação deve obedecer a características intrínsecas de cada manifestação. Neste sentido este estudo apresenta evidências de validade para os instrumentos e aponta para que novas avaliações respeitem características de cada manifestação clínica."
Void shape in gas-channel ribs in gas-assisted injection-molded plates (1999)

Large, thin, plate-shaped parts are usually strengthened with structural ribs.Ribs also serve as gas channels with gas-assisted technology.Gas penetration in the gas channels results in improved moldability and also eliminates sink marks and prevents warpage.However, gas leaves the rib core void, which degrades rigidity.This study examines the shape of the gas void and its relation to rib geometry and processing conditions.The effects of rib geometry, including aspect ratio and fillet geometry, along with processing conditions such as delay time, melt temperature, gas pressure and characteristics of the GAIM molded parts on void shapes are investigated.Numerical simulation of temperature distribution in the rib area is used to aid interpretations of gas void shapes.
Plasma-assisted atomic layer deposition of Al-2O3 on polymers (2006)

Thin Al2O3 films were deposited on silicon and poly(2,6 ethylenenaphthalate) (PEN) substrates by means of plasmaassisted atomic layer deposition (PA-ALD) carried out at low substrate temperature (25-200°C) and consisting of sequential trimethylaluminum (TMA) and (remote) O2 plasma exposures. Because of the advances which ALD could bring to the area of flexible electronics in terms of deposition of ultra thin, conformal,\nvirtually defect- free moisture permeation barriers, ALDof inorganic layers (mainly Al2O3) on polymers is presently actively under investigation. In this contribution we address\nthe PA-ALD Al2O3 film characterization, as well as the initial evaluation of the moisture permeation barrier properties of the Al2O3/PEN composites. Moreover, we briefly comment on the advantages related to the use of PA-ALD compared to thermal ALD processes when low substrate temperatures are chosen.