gebhart/patrepeval huggingface dataset:
Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart (2000)

Vascular endothelial growth factor (VEGF) plays important roles in physiological and pathological angiogenesis. Recent studies have demonstrated that direct injection of VEGF protein, plasmid DNA, or an adenoviral vector encoding the VEGF gene into ischemic myocardium or limb can induce collateral blood vessel formation and improve perfusion of the ischemic areas. However, these approaches have limitations ranging from a short-lasting effect to angioma formation. In this study, we investigated the feasibility of using adeno-associated viral (AAV) vectors to deliver VEGF genes to mouse myocardium. A cytomegalovirus promoter was used to drive genes for a human VEGF isoform, VEGF(165), and LacZ. A mouse myocardial ischemic model was generated by ligation of the anterior descending coronary artery. Approximately 10(11) copies of the AAV-VEGF vector mixed with 10(10) copies of AAV-LacZ were injected to one site of normal myocardium and a total of 10(11) copies of AAV-VEGF were injected to multiple sites of myocardium around the ischemic region. LacZ gene expression was observed up to 3 months after the vector inoculation. After AAV-VEGF inoculation, neoangiogenesis was observed in the ischemic heart model but not in normal heart tissue. An inflammatory-cell infiltration was not observed in the AAV-VEGF- and AAV-LacZ-inoculated hearts, and angioma-like structure was not observed. These results indicated that injection of the AAV vector directly to myocardium could mediate efficient gene transfer and transgene expression and that VEGF gene delivered by AAV vector can induce angiogenesis in ischemic myocardium.
IR spectroscopic studies in microchannel structures (1998)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation A. E. Guber, W. Bier; IR spectroscopic studies in microchannel structures. AIP Conf. Proc. 1 June 1998; 430 (1): 480–486. https://doi.org/10.1063/1.55713 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Circulating Endothelial Progenitor Cells in Cerebrovascular Disease (2008)

Stroke is associated with high disability and mortality burdens worldwide, but there are few effective and widely available therapies. There is therefore a need to develop treatments that promote the repair and regeneration of ischemic brain tissue. In this regard, a population of adult stem cells-called endothelial progenitor cells (EPCs)-has been identified in peripheral blood that could provide novel approaches in regenerative medicine for curing patients with acute ischemic stroke. There is accumulating evidence that EPCs can repair damaged endothelia and attenuate the development and progression of atherosclerosis. Also, EPCs can be recruited in response to acute ischemic events and participate in reparative vasculogenesis. Most studies related to EPCs have involved patients with cardiovascular diseases, and there is emerging evidence that EPCs represent a risk marker and a potential therapeutic agent in cerebrovascular disease. Here we review the characteristics and biology of EPCs in cerebrovascular disease and discuss the challenges that must be addressed to clarify the role and therapeutic applicability of EPCs in cerebrovascular disease.
Studies of an Accumulator Energy-Storage Automobile Design with a Single Pump/Motor Unit (1985)

<div class="htmlview paragraph">An internal combustion engine/hydropneumatic accumulator energy storage automobile can provide for regenerative braking and more efficient engine operation. A configuration is considered which requires only a single hydrostatic pump-motor (P/M) unit. The engine drives through a gearbox to a final reduction unit at the drive axle. The variable-displacement P/M unit is geared to the gearbox input shaft and controlled to alternately put energy into or take energy out of the accumulator. Computer simulations covering a wide range of parameter variations show that, with a proper control strategy, the concept has the potential of providing significant fuel savings.</div>
A new high performance sigma-delta MEMS accelerometer for inertial navigation (2015)

MEMS accelerometers have proven high reliability, cost-effectiveness and versatility in recent years for consumer grade applications. Sagem and Colibrys have long been involved in MEMS accelerometers, with the ACSIL sensor that has been around for over 20 years on APIRS Attitude and Heading Reference Systems and more recently the MS90xx product family. MEMS sensors have been expected to reach inertial navigation grade performance for some years, however very few indeed have been up to the task. In this paper, we present the latest capacitive spring mass sigma-delta closed-loop accelerometer design by Sagem and Colibrys. We will present the key concepts for high performance, system architecture and the experimental results obtained on our prototypes. Compared to previous publications, performance has been significantly improved thanks to improvements in MEMS design, packaging and electronic control. The resulting design features compact size despite full digital electronic integration, excellent robustness to shocks and vibrations, and unmatched performance for a MEMS accelerometer. Great emphasis was placed on having an autonomous sensor, requiring only power supplies and a digital communication interface. High performance is thus achieved independently of external high precision components such as voltage references or A/D converter.
Allergie airborne contact dermatitis from essential oils used in aromatherapy (1995)

Contact allergy to various essential oils used in aromatherapy was demonstrated on patch testing in a 53-year-old patient suffering from relapsing eczema resistant to therapy on various uncovered parts of the skin, in particular the scalp, neck and hands. Sensitization was due to previous exposure to lavender, jasmine and rosewood. Laurel, eucalyptus and pomerance also produced positive tests, although there was no hint of previous exposure. A diagnosis of allergic airborne contact dermatitis was thus established. On topical and systemic glucocorticoid treatment (peroral methylprednisolone at an initial dose of 60 mg/day) the skin lesions eventually resolved. Due to persistence of the volatile essential oils in the patient's home after a year-long use of aroma lamps, complete renewal of the interior of the patient's flat was considered essential. Due to changing self-medication habits, with increasing orientation to 'natural' modes of treatment, increasing numbers of such sensitizations might be on the horizon.
Connexin 43 and ischemic preconditioning (2004)

Connexin 43 (Cx43) is the essential protein to form hemichannels and gap junctions in the myocardium. The phosphorylation status of Cx43 which is regulated by a variety of protein kinases and phosphatases determines hemichannel and/or gap junction conductance and permeability. Gap junctions are involved in cell-cell coupling while hemichannels contribute to cardiomyocyte volume regulation. Cx43-formed channels are involved in ischemia/reperfusion injury, since blockade of a large portion of Cx43-formed channels attenuates ischemic hypercontracture, infarct development and post myocardial infarction remodeling. Ischemic preconditioning's protection also depends on functional Cx43-formed channels, since uncoupling of channels or genetic Cx43 deficiency abolishes infarct size reduction by ischemic preconditioning. The exact underlying mechanism(s) how Cx43 mediates protection remain to be established.
Contribution of Inadequate Arterial Remodeling to the Development of Focal Coronary Artery Stenoses (1997)

Inadequate remodeling is present in at least 15% of chronic, focal, new coronary arterial stenoses in patients with stable angina. The magnitude of arterial remodeling appears to be a lesion-specific response.
A new dopant activation technique for poly-Si TFTs with a self-aligned gate-overlapped LDD structure (2002)

We proposed a new low temperature process for self-aligned gate overlapped LDD (GOLDD) poly-Si TFTs. The gate-overlapped LDD structure was self-aligned by side-etch of Al-Nd in Al-Nd/Mo gate electrode. A low temperature dopant activation was done by using H/sub 2/ ion doping after 450/spl deg/C annealing, in N/sub 2/ atmospheric. The characteristics of our GOLDD poly-Si TFT had high ON-current and low OFF-current.
PANOVA: A pilot study of TTFields concomitant with gemcitabine for front-line therapy in patients with advanced pancreatic adenocarcinoma. (2016)

269 Background: TTFields are alternating electric fields delivered to the region of the tumor by means of non-invasive transducer arrays. TTFields interfere with mitotic spindle formation, thus having an anti-mitotic activity. In pancreatic cancer, TTFields decreased proliferation and clonogenic potential in vitro, and reduced tumor volume in vivo. The PANOVA trial was designed to test TTFields, combined with chemotherapy, in pancreatic cancer. Methods: Twenty patients with advanced pancreatic adenocarcinoma were enrolled in a prospective, single arm study of TTFields at 150 kHz, concomitant with standard weekly gemcitabine. All patients had histologically-confirmed unresectable tumors, with an ECOG performance score of 0-1 and no prior chemotherapy or radiation therapy. The primary endpoint was incidence and severity of treatment emergent adverse events (AEs). Secondary endpoints included progression free survival (PFS), PFS rate at 6 months, overall survival (OS) and response rate. Results: The median age was 73 (range – 49-81) and 60% of the patients were females. Most patients (80%) had an ECOG score of 1. Twelve patients (60%) had distant metastases, while the others had locally advanced disease. Median compliance with TTFields was 78% (14 hours/day), with median duration of 5 months. Fourteen patients (70%) had serious (grade 3-5) AEs during the study period. Six patients (30%) had hematological, 45% gastrointestinal and 15% pulmonary AEs. Ten patients (50%) had treatment-related skin toxicity, of which only 2 were grade 3, both resolved with appropriate treatment. No TTFields-related serious AEs were reported. The median PFS was 8.3 months (95% CI 4.3, 10.3). PFS rate at 6 months was 56%. Of the evaluable tumors, 30% had partial response and another 30% stable disease. The median OS was 14.9 months and 1-year survival rate was 55%. Conclusions: TTFields concomitant to gemcitabine are tolerable and safe for advanced pancreatic cancer patients. The efficacy results are promising and support further research in this indication. An extension of the PANOVA protocol, including 20 additional patients who receive gemcitabine, nab-paclitaxel and TTFields is ongoing. Clinical trial information: NCT01971281.
Human <i>HOX</i> gene mutations (2001)

HOX genes play a fundamental role in the development of the vertebrate central nervous system, axial skeleton, limbs, gut, urogenital tract and external genitalia, but it is only in the last 4 years that mutations in two of the 39 human HOX genes have been shown to cause congenital malformations; HOXD13, which is mutated in synpolydactyly, and HOXA13, which is mutated in Hand-Foot-Genital syndrome. Here we review the mutations already identified in these two genes, consider how these mutations may act, and discuss the possibility that further mutations remain to be discovered both in developmental disorders and in cancer.
Pressurized hot water extraction of bioactives (2015)

The purpose of this review is to give the reader a thorough background to the fundamentals and applications of pressurized hot water extraction (PHWE) for the analysis of bioactive compounds. We summarize the field in the period 2009–14, and include fundamentals of water as a solvent: equipment; method optimization; applications; coupling; and, future prospects. We highlight that solvent properties of water are tunable by changing the temperature, particularly self-ionization, dielectric constant, viscosity, diffusivity, density and surface tension. Furthermore, important aspects to consider are the risk of degradation of the analytes and other potential reactions, such as hydrolysis, caramelization and Maillard reactions that may lead to erroneous results. For the extraction of bioactive compounds, we report PHWE methods based on using water of 80–175°C and short extraction times. In conclusion, PHWE provides advantages over conventional extraction methods, such as being “greener”, faster and more efficient.
Microporous Materials Constructed from the Interpenetrated Coordination Networks. Structures and Methane Adsorption Properties (2000)

Five new coordination compounds with 4,4‘-azopyridine (azpy), [Mn(azpy)(NO3)2(H2O)2]·2EtOH (1·2EtOH), [Co2(azpy)3(NO3)4]·Me2CO·3H2O (2·Me2CO·3H2O), [Co(azpy)2(NCS)2]·0.5EtOH (3·0.5EtOH), [Cd(azpy)2(NO3)2]·(azpy) (4·azpy), and [Cd2(azpy)3(NO3)4]·2Me2CO (5·2Me2CO), have been synthesized and structurally characterized. The reaction of Mn(NO3)2·6H2O with azpy in ethanol/acetone affords 1·2EtOH, whose network consists of one-dimensional chains of [Mn(azpy)(H2O)2]n. The chains are associated by hydrogen bonding to provide a logcabin-type three-dimensional structure, which creates about 8 × 8 Å of channels, filled with ethanol molecules. The treatment of Co(NO3)2·6H2O and Co(NCS)2·4H2O with azpy produces 2·Me2CO·3H2O and 3·0.5EtOH, respectively, which have a brick-wall and a rhombus-type two-dimensional networks. The reaction of Cd(NO3)2·4H2O with azpy affords 4·azpy from the ethanol/H2O media, while the reaction in the ethanol/acetone media provides 5·2Me2CO. 4·azpy and 5·2Me2CO form a square-grid- and a herringbone-type two-dimensional networks, respectively. The two-dimensional sheets of 4·azpy stack without interpenetration, leading to large size of channels, which are filled with free azpy molecules. The two-dimensional networks of 2·Me2CO·3H2O, 3·0.5EtOH, and 5·2Me2CO are quadruply, doubly, and triply interpenetrated, respectively. Despite the interpenetration, their networks create the microporous channels filled with guest solvent molecules. The dried compounds 2, 3, and 5 adsorb methane between 1 and 36 atm at 25 °C, in which 3 and 5 exhibit Langmuir-type isotherms. The inherent micropore volumes for 3 and 5 are 0.685 and 3.30 mmol/g, respectively. XRPD measurements under reduced pressure at 100 °C reveal that the channel structure of 3 is the most stable in these compounds; the observed XRPD pattern is in good agreement with that of the simulated pattern of the single-crystal model. Compounds 2 and 5 also retain the porous structures, however, their pore structures are distorted upon loss of guest included molecules.
Efficient parameter quantisation for 2.4/1.2 kb/s split-band LPC coding (2002)

Speech coding at very low bit rates has many applications such as answering machines, IP telephony, mobile communications, military communications etc. Most low bit rate coders operate at around 2.4 kb/s, as the speech quality degrades too much below this bit rate. We describe a frequency domain speech coder capable of operating at both 2.9 and 1.2 kb/s, and produces good quality synthesised speech. Both rates use the same analysis and synthesis building blocks over 20 ms, but the 1.2 kb/s coder jointly quantises three sets of parameters every 60 ms to reduce the bit rate while maintaining speech quality. We also describe the quantisation methods used to lower the bit rate from 2.4 kb/s to 1.2 kb/s while retaining most of the quality of the higher bit rate version.
The Effects of Ceramic Coatings on Diesel Engine Performance and Exhaust Emissions (1991)

<div class="htmlview paragraph">An experimental investigation of the effects of ceramic coatings on diesel engine performance and exhaust emissions was conducted. Tests were carried out over a range of engine speeds at full load for a standard metal piston and two pistons insulated with 0.5 mm and 1.0 mm thick ceramic coatings. The thinner (0.5 mm) ceramic coating resulted in improved performance over the baseline engine, with the gains being especially pronounced with decreasing engine speed. At 1000 rpm, the 0.5 mm ceramic coated piston produced 10% higher thermal efficiency than the metal piston. In contrast, the relatively thicker coating (1 mm), resulted in as much as 6% lower thermal efficiency compared to baseline. On the other hand, the insulated engines consistently presented an attractive picture in terms of their emissions characteristics. Due to the more complete combustion in the insulated configurations, exhaust CO levels were between 30% and 60% lower than baseline levels. Similarly, unburned HC levels were 35% to 40% lower for the insulated pistons. The NO<sub>x</sub> concentrations were also 10% to 30% lower due to the changed nature of combustion in the insulated engines. Finally, smoke emissions decreased slightly in the insulated engines.</div>
Preparation of High Concentration O/W and W/O Emulsions by the Membrane Phase Inversion Emulsification Using PTFE Membranes. (1999)

A new phase inversion method was developed by modifying the membrane emulsification method with preliminary emulsification. A phase-inverted O/W emulsion of which the volume fraction of dispersed phase, φ, was higher than 0.5 was prepared by passing a pre-emulsified low concentration W/O emulsion (φ<0.5) through a hydrophilic polytetrafluoroethylene (PTFE) membrane. A hydrophobic PTFE membrane was used to prepare the phase-inverted W/O emulsion from the pre-emulsified O/W emulsion. The highest dispersed phase volume fraction, φmax, of the phase-inverted emulsions obtained in this study was 0.90 and 0.84 for the O/W and for the W/O type emulsions respectively. The phase-inverted high concentration emulsions showed high stability. The values of φmax as well as the stability of the phase-inverted emulsions depended on the kind and concentration of emulsifying agents used.
Conjugation of some NSAIDs with 5-phenyl-2-aminothiazole for reduced ulcerogenicity (2010)

Analgesic drugs containing free acidic group were reacted with N, Ncarbonyldiimidazole to prepare the acylimidazole derivatives. They were further reacted with 5-phenyl-2-amino thiazole nucleus to obtain the corresponding amides. All the compounds were found to retain analgesic-antiinflammatory activities with much lesser NSAID-induced GI complications when compared with the standard.
Electromigration time to failure of SnAgCuNi solder joints (2009)

Electromigration time to failure and electrical resistivity of 95.5%Sn–1.5%Ag–0.5%Cu–0.03W%Ni microelectronics solder joints have been investigated experimentally. A Black-type electromigration time to failure equation is developed to describe the time to failure versus current density and temperature. It is observed that resistance of a solder joint is not just a function of the temperature but also a function of the current density. The activation energy over the range of 83–174°C is measured to be 0.77±0.12eV, and the current density exponent is found to be (8.60±1.65). It is also shown that the most commonly used Black’s electromigration time to failure equation cannot be used for solder joints.
A 6.4 kbit/s extension to the G.729 speech coder (2002)

This paper proposes a 6.4-kbit/s extension to the G.729 speech coder. Each G.729 module was investigated to determine which bits could be removed without hurting the speech quality, then a 6.4-kbit/s coder was designed. This coder has an 11-bit algebraic codebook that uses two or three pulses. We also propose a conditional orthogonalized search for the fixed codebook to improve the speech quality. The conditional orthogonalized search chooses one of two search methods (orthogonalized or non-orthogonalized) based on the optimum pitch gain. Subjective tests have indicated that the quality of the proposed coder is equivalent to that of the 6.3-kbit/s G.723.1 coder.
Computational optimization of preditive filter for noise cancellation (1990)

Noise cancellation of stationary random signals has been obtained at an isolated point in space. This has been done without using adaptive techniques, an error microphone, or any sort of “upstream” preview of a signal correlated with the noise source. The antinoise speaker is driven by a digital signal processor implementing an IIR filter using sampled input from a microphone placed at the point where noise cancellation is desired. By using a simple physical model of the total noise at the microphone, the coefficients of the DSP IIR filter can be defined. A linear prediction has been incorporated into the IIR filter in order to anticipate the level of sound that will be produced by the noise source in the future. Experimental cancellation results were attained by using an initial guess of the optimal IIR DSP implemented filter. The work presented here involves computationally finding the set of filter coefficients that gives the theoretically optimal reduction in noise. The total reduction in decibels of the entire noise spectrum is minimized subject to the constraint of feedback stability.
Association of <i>Helicobacter pylori</i> Infection with Gastric Adenocarcinoma (1998)

Gastric adenocarcinoma is the most prevalent cancer in South Korea, and Helicobacter pylori (H. pylori) infection is also common. This study was performed to examine the association between H. pylori infection and gastric cancer, taking into account various other factors. To investigate the association between gastric adenocarcinoma and H. pylori infection, determined by urease-positive reaction in the CLO test, a total of 175 paired specimens (175 tumor and 175 tissues adjacent to tumor) of stomach cancer patients and a total of 113 control specimens were obtained. The positive H. pylori infection rates were 78.9% (138/175) among the patients in specimens of tumor or tissues adjacent to the tumor and 41.6% (47/113) among controls in the CLO test. A positive correlation between H. pylori infection and gastric cancer was observed (age-adjusted odds ratio, 7.0; MH chi2=34.5 with P<0.0005). These data suggest that stomach cancer patients in Korea have high infection rates of H. pylori regardless of site specificity, and this infection might be causally associated with stomach cancer.
Monolithically-Integrated TE-mode 1D Silicon-on-Insulator Isolators using Seedlayer-Free Garnet (2017)

The first experimental TE-mode silicon-on-insulator (SOI) isolators using Faraday Rotation are here realized to fill the 'missing link' in source-integrated near infrared photonic circuits. The isolators are simple 1D 2-element waveguides, where garnet claddings and longitudinal magnetic fields produce nonreciprocal mode conversion, the waveguide equivalent of Faraday Rotation (FR). Quasi-phase matched claddings are used to overcome the limitations of birefringence. Current experimental SOI isolators use nonreciprocal phase shift (NRPS) in interferometers or ring resonators, but to date NRPS requires TM-modes, so the TE-modes normally produced by integrated lasers cannot be isolated without many ancillary polarisation controls. The presented FR isolators are made via lithography and sputter deposition, which allows facile upscaling compared to the pulsed laser deposition or wafer bonding used in the fabrication of NRPS devices. Here, isolation ratios and losses of 11 dB and 4 dB were obtained, and future designs are identified capable of isolation ratios >30 dB with losses <6 dB.