gebhart/patrepeval huggingface dataset:
Perspective: Engineering noise in biological systems towards predictive stochastic design (2018)

Significant progress has been made towards engineering both single-cell and multi-cellular systems through a combination of synthetic and systems biology, nanobiotechnology, pharmaceutical science, and computational approaches. However, our ability to engineer systems that begin to approach the complexity of natural pathways is severely limited by important challenges, e.g. due to noise, or the fluctuations in gene expression and molecular species at multiple scales (e.g. both intra- and inter-cellular fluctuations). This barrier to engineering requires that biological noise be recognized as a design element with fundamentals that can be actively controlled. Here we highlight studies of an emerging discipline that collectively strives to engineer noise towards predictive stochastic design using interdisciplinary approaches at multiple-scales in diverse living systems.
Crystal Structures of Clay Minerals and their X-Ray Identification (1980)

Abstract In the years 1930—1950 clay mineral identification involved mainly a combination of X-ray powder diffraction and chemical analysis with some assistance from other techniques, notably differential thermal analysis. In the period 1950—1970 additional procedures have emerged including infrared analysis, electron optical methods and a variety of thermal methods. These procedures are now treated in other monographs sponsored by the Mineralogical Society and in many other publications. Despite the availability of other techniques, X-ray diffraction remains a basic tool for studying minerals and we hope that this monograph will continue to serve, as did the previous editions, both those concerned with the more academic aspects of clay mineralogy and also those, such as geologists, civil engineers and soil scientists, for whom identification and quantitative estimation of the minerals in natural clayey materials is a practical requirement.
Truth: A Primer. (1997)

Introduction Realism and Idealism Absolutism and Relativism Pragmatism The Coherence Theory Deflationism The Correspondence Theory Truth and Knowledge Conclusion.
Hydraulic hybrid vehicle vibration isolation control with magnetorheological fluid mounts (2013)

Hydraulic Hybrid Vehicle (HHV) is an emerging technology especially for heavy-duty vehicles, thanks to its high efﬁciency and power density. However, one of the main problems that should be solved to enable the successful commercialisation of HHV is the excessive noise and vibration involved with hydraulic systems. This study focuses on using the magnetorheological ﬂuid (MRF) technology to reduce the noise and vibration transmissibility from the power sources to the vehicle body. To study the noise and vibration of HHVs, a HHV structure in parallel design was analysed. An MRF mount, to use for the engine and pump/motor, was designed, fabricated and tested. Vibration control schemes based on the skyhook algorithm were utilised to reduce the transmissibility and amplitudes of vibration. The research showed that the MRF mounts played an important role in reducing the noise and vibration transmitted to the vehicle body. Additionally, the locations and orientations of the isolation system affected the efﬁciency of the noise and vibration mitigation.
Evaluation of a commercially available second-generation immunoglobulin G enzyme immunoassay for detection of Helicobacter pylori infection (1992)

We evaluated a commercially available second-generation anti-H. pylori immunoglobulin G enzyme immunoassay (EIA) (Cobas Core Anti-Helicobacter pylori EIA; Roche S. A., Basel, Switzerland) for serodiagnosis of H. pylori infection. The results of the assay were assessed in relation to the results of bacterial culture, urease testing, and histological Giemsa stain of gastric biopsy specimens from 1,134 patients with a variety of symptoms relating to the upper gastrointestinal tract. H. pylori was detected in biopsy specimens from 660 (58.2%) patients: 6 had a normal mucosa, 123 had chronic gastritis only, and 531 were found to have chronic active gastritis by histology; endoscopy showed duodenal and gastric ulcers in 137 and 64 patients of the last two groups, respectively. The test was evaluated with different age and ethnic groups. The prevalence, sensitivity, specificity, and positive and negative predictive values were, respectively, (i) for Belgian patients between 18 and 40 years old, 34, 93, 95, 91, and 96%; (ii) for Belgian patients more than 40 years old, 53, 96, 91, 93, and 95%; and (iii) the Mediterranean patients more than 17 years old, 87, 94, 70, 95, and 64%. All sera showing discordant immunoassay results compared with the results of histology and culture of biopsy specimens, as well as those with borderline immunoassay results, were tested further by immunoblotting. Among the EIA results considered false negative, we demonstrated an absence of seroconversion in 14 of 19 patients tested by immunoblotting. Among the EIA results considered false positive, immunoblotting showed the presence of specific antibodies in 28 of 37 patients tested. Among the borderline results obtained in the first assay with 22 patients' sera, a second assay showed positive results in 10 patients (8 were positive by immunoblotting) and negative reactions in 10 patients (9 were negative by immunoblotting), whereas 2 remained borderline. These data indicate that sera showing borderline immunoassay results must be tested again. In conclusion, this commercially available second-generation EIA, which is easy and quick to perform, was found highly reliable for the serodiagnosis of H. pylori infection.
China : Greenhouse gas control in the agricultural sector (1994)

This report concerns the agriculturally related emissions of two greenhouse gases, methane and nitrous oxide, in the People's Republic of China. Rice paddies, domesticated animals and their waste, and crop residue burning are the sources of methane considered, while fertilizer applications and crop residue burning are considered as sources of nitrous oxide. The report is presented in three sections. The first section estimates China's emissions of methane and nitrous oxide in 1988 and 1990 from the sources noted above. The second summarizes Chinese research aimed at reducing emissions. Finally, projections of emissions levels to the year 2020 are made.
Motor Responses to Sudden Limb Displacements in Primates with Specific CNS Lesions and in Human Patients with Motor System Disorders (1975)

Central feedback pathways for motor control were studied by recording EMG responses to sudden upper limb displacements in humans and monkeys using a precision torque motor to generate step load changes. Normal human subjects showed three short-latency EMG responses (M1, M2 and M3) which appear to correspond to those recorded from trained monkeys. The M2 and M3 components, thought to represent feedback in supraspinal pathways, were significantly increased when the subjects were instructed to actively compensate for the load changes. Parkinsonian patients with rigidity showed evidence of markedly increased feedback over the interval for the M2 and M3 responses and appeared to have lost the ability to modulate feedback according to the motor task being performed. The results are discussed with reference to recent research on motor control mechanisms in primates and a tentative model for the basis of Parkinsonian rigidity is proposed.
PPARα agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition (2008)

Angiogenesis and inflammation are central processes through which the tumor microenvironment influences tumor growth. We have demonstrated recently that peroxisome proliferator-activated receptor (PPAR)α deficiency in the host leads to overt inflammation that suppresses angiogenesis via excess production of thrombospondin (TSP)-1 and prevents tumor growth. Hence, we speculated that pharmacologic activation of PPARα would promote tumor growth. Surprisingly, the PPARα agonist fenofibrate potently suppressed primary tumor growth in mice. This effect was not mediated by cancer-cell-autonomous antiproliferative mechanisms but by the inhibition of angiogenesis and inflammation in the host tissue. Although PPARα-deficient tumors were still susceptible to fenofibrate, absence of PPARα in the host animal abrogated the potent antitumor effect of fenofibrate. In addition, fenofibrate suppressed endothelial cell proliferation and VEGF production, increased TSP-1 and endostatin, and inhibited corneal neovascularization. Thus, both genetic abrogation of PPARα as well as its activation by ligands cause tumor suppression via overlapping antiangiogenic pathways. These findings reveal the potential utility of the well tolerated PPARα agonists beyond their use as lipid-lowering drugs in anticancer therapy. Our results provide a mechanistic rationale for evaluating the clinical benefits of PPARα agonists in cancer treatment, alone and in combination with other therapies.
Über das Problem des Diamanten (1915)

Die Existenzgebiete von Diamant und Graphit behandelte zuerst ROOZEBOOM.Ausgehend von cler Erfahrung, da13 Diamant bei hohen Temperaturen2 in Graphit iibergeht, und von der BER-THELOT-PETITSChen Umwandlungswarme von Graphit (G) in Diamant (D) pro Mol: G=D+500cal bei 17OC,
Reflow-curable polymer fluxes for flip chip encapsulation (2002)

Generally, in the process of flip chip assembly on polymer-glass printed circuits, flip-chips are underfilled with a glass-powder-filled epoxy encapsulant and cured. The underfilling is required to produce reliable solder joints. The reliability of the final assembly hinges on the coefficient of thermal expansion (CTE) and modulus of the encapsulant. A CTE of 20-3a ppm//spl deg/C and a modulus exceeding 6 GPa are necessary to achieve the required lifetime of 2000-4000 thermal cycles at -25 to 125/spl deg/C. Yet the underfill process during assembly is expensive and time consuming. New fluxes that crosslink during reflow have been developed. They can be filled with ceramic or glass powders to achieve the required CTE and modulus. When these polymer fluxes are used in flip chips, a robust assembly is created without the need to underfill. We will report on a multilayer approach to flip chip assembly that eliminates the need for post-reflow underfilling.
Hijacking the Hijackers: Escherichia coli Pathogenicity Islands Redirect Helper Phage Packaging for Their Own Benefit (2019)

Phage-inducible chromosomal islands (PICIs) represent a novel and universal class of mobile genetic elements, which have broad impact on bacterial virulence. In spite of their relevance, how the Gram-negative PICIs hijack the phage machinery for their own specific packaging and how they block phage reproduction remains to be determined. Using genetic and structural analyses, we solve the mystery here by showing that the Gram-negative PICIs encode a protein that simultaneously performs these processes. This protein, which we have named Rpp (for redirecting phage packaging), interacts with the phage terminase small subunit, forming a heterocomplex. This complex is unable to recognize the phage DNA, blocking phage packaging, but specifically binds to the PICI genome, promoting PICI packaging. Our studies reveal the mechanism of action that allows PICI dissemination in nature, introducing a new paradigm in the understanding of the biology of pathogenicity islands and therefore of bacterial pathogen evolution.
Effect of therapeutic dosage of lithium on the heart. (1980)

1 The cardiac effects of therapeutic levels of lithium were investigated in six healthy male volunteers. Subjects were studied: (1) before lithium ingestion, and (2) when steady-state plasma lithium levels were attained (at least 2 weeks after beginning daily lithium ingestion). 2 A 12-lead electrocardiogram (ECG) and high-speed high-fidelity ECG were used to record electrical activity of the heart. Fractional shortening of the left ventricle using echocardiography, and systolic time intervals (at rest and during exercise), were used as measures of myocardial performance. 3 In this group of healthy volunteers administration of lithium carbonate was associated with a reduction in T wave amplitude in standard electrocardiograms but no statistically significant impairment of myocardial performance.
Coordinate Transformation for Phased Array Antenna Beam Steering Using GPS and Ship's Motion Data (2000)

Abstract : Beam steering angles of a shipboard phased array antenna are calculated, given the position of the ship, the position and attitude of the antenna on the ship, and the ship's bearing, roll, and pitch angles. The coordinate transformations were written in MATLAB; the pertinent software is added in the Appendix. An example of an application is given.
Dual-Band Loop-Dipole Composite Unidirectional Antenna for Broadband Wireless Communications (2014)

The design of a novel dual-band loop-dipole composite unidirectional antenna for broadband wireless applications is proposed. First, design guidelines of the antenna are presented, and then, a step-by-step derivation of the antenna geometry is drawn. The antenna's operation principle is analyzed by carrying out parametric studies of surface current distribution, impedance and radiation patterns. The reflection coefficient, radiation patterns and gain of the antenna are numerically and experimentally studied to verify the operation principle and the design approach. It is demonstrated that two pass-bands, from 1.54 to 3.24 and from 4.88 to 6.80 GHz, of reflection coefficient smaller than -10 dB are obtained. The antenna has stable and unidirectional radiation pattern with low cross polarization within its pass-bands. The average gain of the antenna is 6.7 dBi at low frequency band and 6.5 dBi at high frequency band.
Sorafenib in non-small cell lung cancer (2012)

Sorafenib has shown anti-tumor activity in NSCLC. However, because NSCLC is complex and molecularly heterogeneous, it is very likely that only a subset of NSCLC patients will benefit from sorafenib, and so it is imperative to discover biomarkers to select patients who will probably benefit from sorafenib. Combination with other agents targeting parallel and compensatory pathways, such as EGFR inhibitors, may offer broader coverage and better disease control.
On adaptive acquisition of language (2002)

A system that automatically acquires a language model for a particular task from semantic-level information is described. This is in contrast to systems with predefined vocabulary and syntax. The purpose of the system is to map spoken or typed input into a machine action. To accomplish this task a medium-grain neural network is used. An adaptive training procedure is introduced for estimating the connection weights. It has the advantages of rapid, single-pass and order-invariant learning. The resulting weights have information-theoretic significance and do not require gradient search techniques for their estimation. The system was experimentally evaluated on three text-based tasks; a three-class inward-call manager with an acquired vocabulary of over 1600 words, a 15-action subset of the DARPA Resource Manager with an acquired vocabulary of over 700 words, and discrimination between idiomatic phrases meaning yes or no.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
<i>Candida albicans</i>pathogenicity mechanisms (2013)

The polymorphic fungus Candida albicans is a member of the normal human microbiome. In most individuals, C. albicans resides as a lifelong, harmless commensal. Under certain circumstances, however, C. albicans can cause infections that range from superficial infections of the skin to life-threatening systemic infections. Several factors and activities have been identified which contribute to the pathogenic potential of this fungus. Among them are molecules which mediate adhesion to and invasion into host cells, the secretion of hydrolases, the yeast-to-hypha transition, contact sensing and thigmotropism, biofilm formation, phenotypic switching and a range of fitness attributes. Our understanding of when and how these mechanisms and factors contribute to infection has significantly increased during the last years. In addition, novel virulence mechanisms have recently been discovered. In this review we present an update on our current understanding of the pathogenicity mechanisms of this important human pathogen.
Interference management in LTE femtocell systems using Fractional Frequency Reuse (2010)

Recently, Long Term Evolution (LTE) has developed a femtocell for indoor coverage extension. However, interference problem between the femtocell and the macrocell should be solved in advance. In this paper, we propose an interference management scheme in the LTE femtocell systems using Fractional Frequency Reuse (FFR). Under the macrocell allocating frequency band by the FFR, the femtocell chooses sub-bands which are not used in the macrocell sub-area to avoid interference. Simulation results show that proposed scheme enhances total/edge throughputs and reduces the outage probability in overall network, especially for the cell edge users.
A bidomain model of epiretinal stimulation (2005)

A computational bidomain model of epiretinal stimulation is presented, consisting of a continuum description of active retinal tissue in contact with bulk vitreous fluid. Results from two-electrode and four-electrode bipolar stimulation suggest that a biphasic cathodic-anodic stimulus sequence is effective in providing targeted focal activation of retinal tissue. Undesired secondary activations beneath each electrode return may be eliminated by using multiple returns for each stimulus electrode.
Controlled comparison of the BacT/Alert and BACTEC 660/730 nonradiometric blood culture systems (1992)

In a collaborative study at three university hospitals, the recovery of microorganisms and the speed of detection of microbial growth by the BacT/Alert (Organon Teknika Corporation, Durham, N.C.) and BACTEC 660/730 (Becton-Dickinson Diagnostic Instrument Systems, Sparks, Md.) nonradiometric blood culture systems were compared. A total of 5,918 comparisons were made between BacT/Alert aerobic and BACTEC NR 6A bottles and 5,992 comparisons were made between BacT/Alert anaerobic and BACTEC NR 7A bottles. Each bottle was inoculated with 5 ml of blood. The overall recoveries of microorganisms from the two aerobic bottles were comparable; members of the family Enterobacteriaceae were recovered more often from BacT/Alert aerobic bottles alone (P less than 0.001). The overall recoveries of microorganisms from the anaerobic bottles were not significantly different. Growth of Staphylococcus aureus (P less than 0.001), coagulase-negative staphylococci (P less than 0.01), streptococci (P less than 0.001), Escherichia coli (P less than 0.01), other members of the family Enterobacteriaceae (P less than 0.02), and Pseudomonas aeruginosa (P less than 0.05) was detected earlier in BacT/Alert aerobic bottles. Growth of S. aureus (P less than 0.001), coagulase-negative staphylococci (P less than 0.05), enterococci (P less than 0.01), Streptococcus pneumoniae (P less than 0.02), viridans group streptococci (P less than 0.05), E. coli (P less than 0.001), Klebsiella pneumoniae (P less than 0.01), and other members of the family Enterobacteriaceae (P less than 0.001) was detected earlier in BacT/Alert anaerobic bottles. In a system-versus-system comparison, more gram-positive cocci were recovered from the BACTEC system alone (P < 0.05), and more members or the family Enterobacteriaceae were recovered from the BacT/Alert system alone (P < 0.001). As a system, the BacT/Alert system detected growth of S. aureus (P < 0.001), coagulase-negative staphylococci (P < 0.01), streptococci (P < 0.001), E. coli (P < 0.001), other members of the familyEnterobacteriaceae (P < 0.001), and P. aeruginosa (P < 0.05) earlier than the BACTEC system did. Significantly fewer (40 versus 1,183) false-positive results occurred with the BacT/Alert system. We conclude that the BacT/Alert and BACTEC 660/730 nonradiometric systems are comparable for recovering clinically significant microorganisms form adult patients with bacteremia or fungemia, but that the BacT/Alert system detects microbial growth earlier than the BACTEC system does, with significantly fewer false-positive results.
Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. (1988)

The contribution of the Fiorinal and codeine phosphate components to the effectiveness of the Fiorinal with Codeine combination in the treatment of tension headache symptoms was evaluated in a randomized, placebo-controlled, multicenter double-blind study. Patients admitted to the trial took two capsules of Fiorinal with Codeine, Fiorinal alone, codeine alone, or placebo during each of two tension headache attacks. Immediately before and at intervals up to four hours after drug ingestion, patients rated pain severity, pain relief, the tense and uptight feeling, and muscle stiffness. The response to treatment was evaluated in 154 patients. Despite a high placebo response, a factor known to obscure the contribution of components, Fiorinal and codeine were each found to contribute significantly to the therapeutic effect of the Fiorinal with Codeine combination. Statistical or borderline superiority of the combination drug over Fiorinal alone was seen most frequently at the early evaluations, a finding that reflected the rapid onset of action of codeine. Statistically significant differences between Fiorinal with Codeine and codeine alone seen principally at the later assessments reflected the long duration of action of the Fiorinal component. The frequency of adverse reactions did not differ significantly among the four study groups.
Suzuki Osamu, Sodeisha and ceramic identity in modern Japan (2014)

In Japan, the recent career retrospective, Suzuki Osamu: Image in Clay, exhibited during 2013-2014 at the National Museum of Modern Art in Kyoto, Aichi Prefectural Ceramics Museum, Tokyo Station Gallery and The Hagi Uragami Museum showcased Suzuki's life works. The exhibition marked the 10th anniversary of Suzuki's death and displayed how ingrained his works had become in Japanese culture and art.
Cartilage grafting in facial reconstruction with special consideration of irradiated grafts (1986)

The search for the perfect facial implant for reconstruction of the face continues. Cartilage, once thought to be an undesirable graft material because of its propensity for absorption, has regained popularity in the past decade. Various preparation techniques have been employed to ensure graft sterility and diminished absorption. An improved understanding of cartilage structure and physiology has shed considerable light on the host-graft relationship. Gamma irradiation is a time-honored method of preservation. An experiment was undertaken to investigate the physiology of irradiated cartilage grafts following prolonged implantation on the facial skeleton of sheep and dog. Merthiolate preserved grafts were used as controls. Direct observation, histochemical techniques, autoradiography, and transmission electron micrography were used to determine chondrocyte viability and matrix composition. It was surprising to note that following implantation of 16 to 72 months, complete resorption was seen in 87.7% of the irradiated grafts and in 43.8% of the Merthiolate stored controls. Many of the grafts acquired chondrocytes from the host and produced new proteoglycan matrix as well as undergoing some degree of ossification. A comparison to the clinical situation in humans is made.