gebhart/patrepeval huggingface dataset:
Development of a ZVT-PWM Buck Cascaded Buck–Boost PFC Converter of 2 kW With the Widest Range of Input Voltage (2017)

This paper describes the development of a new buck cascaded buck-boost power factor correction (PFC) converter of 2 kW with a soft-switching technique. For its wide range of input voltage, it operates in both buck and boost modes. The parameters are properly selected to endure voltage and current stress in all operating ranges. In addition, the electromagnetic interference (EMI) filter is used to reduce the EMI noise and guarantee continuous input current in buck operation. Moreover, the zero-voltage-transient pulse-width-modulation (ZVT-PWM) method is applied to improve the overall efficiency of the converter. The performance of the proposed PFC converter with the widest range of input voltage is evaluated by the hardware experimental test including harmonics analysis based on the International Electrotechnical Commission standard in all operating ranges. Also, the variations of power factor are theoretically analyzed in both buck and boost modes to determine the widest input range of the proposed PFC converter of 2 kW with an EMI filter. These are strongly required to commercialize it in practice. Finally, the efficiency of proposed PFC converter is compared with that of a conventional buck cascaded buck-boost PFC converter under various conditions.
Measuring the accuracy of ROM reciprocal tables (1994)

We prove that a convenient ROM reciprocal table construction algorithm generates tables that minimize the relative error. The worst case relative errors realized for such optimally computed k-bits-in, m-bits-out ROM reciprocal tables are then determined for all table sizes 3/spl les/k,m/spl les/12. We next prove the table construction algorithm always generates a k-bits-in, k-bits-out table with relative errors never any greater than 3/4 2/sup -k/, and more generally with g guard bits that for (k+g)-bits-out the relative error is never any greater than 2-(k+1)(1+1/(2g+1)). To provide for determining extreme case test data and to compute the precision of a reciprocal table without prior construction of the full ROM reciprocal table, we describe a procedure that requires generation and inspection of only a small portion of such a table to identify input values guaranteed to include the worst case relative errors in the table.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Development and Verification of Control and Protection Strategies in Hybrid AC/DC Power Systems for Smart Grid Applications (2012)

Modern power networks incorporate communications and information technology infrastructure into the electrical power system to create a smart grid in terms of control and operation. The smart grid enables real-time communication and control between consumers and utility companies allowing suppliers to optimize energy usage based on price preference and system technical issues. The smart grid design aims to provide overall power system monitoring, create protection and control strategies to maintain system performance, stability and security. This dissertation contributed to the development of a unique and novel smart grid test-bed laboratory with integrated monitoring, protection and control systems. This test-bed was used as a platform to test the smart grid operational ideas developed here. The implementation of this system in the real-time software creates an environment for studying, implementing and verifying novel control and protection schemes developed in this dissertation. Phasor measurement techniques were developed using the available Data Acquisition (DAQ) devices in order to monitor all points in the power system in real time. This provides a practical view of system parameter changes, system abnormal conditions and its stability and security information system. These developments provide valuable measurements for technical power system operators in the energy control centers. Phasor Measurement technology is an excellent solution for improving system planning, operation and energy trading in addition to enabling advanced applications in Wide Area Monitoring, Protection and Control (WAMPAC). Moreover, a virtual protection system was developed and implemented in the smart grid laboratory with integrated functionality for wide area applications. Experiments and procedures were developed in the system in order to detect the system abnormal conditions and apply proper remedies to heal the system. A design for DC microgrid was developed to integrate it to the AC system with appropriate control capability. This system represents realistic hybrid AC/DC microgrids connectivity to the AC side to study the use of such architecture in system operation to help remedy system abnormal conditions. In addition, this dissertation explored the challenges and feasibility of the implementation of real-time system analysis features in order to monitor the system security and stability measures. These indices are measured experimentally during the operation of the developed hybrid AC/DC microgrids. Furthermore, a real-time optimal power flow system was implemented to optimally manage the power sharing between AC generators and DC side resources. A study relating to real-time energy management algorithm in hybrid microgrids was performed to evaluate the effects of using
Redundant DC-DC switching power supply system for telecommunication equipment (2003)

A battery-fed multiple-output DC power supply system for telecommunication equipment is described. The system consists of several parallel autonomous power modules with load current sharing and 'n+1' redundancy. Each module contains two parallel double-output current-mode controlled forward converters with integrated output filter inductors. Primary attention is focused on the multiwinding inductor element. A simple and efficient design procedure is developed for the loose coupling of windings, which was found to be favourable from the viewpoint of the dynamic properties of the system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Measurement of fibrinogen binding to platelets in whole blood by flow cytometry: a micromethod for the detection of platelet activation (1990)

Platelet fibrinogen binding in whole blood has been measured in vitro by flow cytometry using a commercially available, fluorescein isothiocyanate (FITC)-conjugated polyclonal antifibrinogen antibody. Fibrinogen-antifibrinogen immune complexes were formed in experimental conditions approaching antigen-antibody equivalence, but optimal reaction conditions in which their formation was prevented or minimized could be achieved. Immune complex formation was associated with fibrinogen binding to unstimulated platelets but did not significantly affect ADP-induced fibrinogen binding. Half-maximal fibrinogen binding occurred at about 0.4 microM ADP, and ADP-induced fibrinogen binding continued progressively during 20 min incubation with 10 microM ADP. Fibrinogen binding correlated closely with platelet glycoprotein IIb-IIIa expression in members of a family with Glanzmann's thrombasthenia, and, in double labelling experiments, with the binding of PAC1, a monoclonal antibody that binds to GP IIb-IIIa only after the exposure of fibrinogen receptors. These studies show that platelet fibrinogen binding can be reliably measured in whole blood by means of a polyclonal antifibrinogen antibody which does not discriminate between plasma and platelet-bound fibrinogen, despite the presence of an approximately 100-fold excess of the former.
Oral and Topical Treatment of Experimental Herpes Simplex Iritis With Bromovinyldeoxyuridine (1982)

• Oral treatment of rabbits with bromovinyldeoxyuridine ([<i>E</i>]-5-[2-bromovinyl]2′-deoxyuridine) at 10 or 100 mg/kg/day for four days significantly reduced the severity of herpes simplex iritis. This effect was not potentiated by the concomitant subconjunctival injection of sustained-action betamethasone. A significant reduction in the severity of herpetic iritis was also observed on topical application of bromovinyldeoxyuridine, and, in this regard, 0.5% bromovinyldeoxyuridine eyedrops proved significantly more efficacious than 1% trifluridine eyedrops.
An Empirical Study of the Applications of Web Mining Techniques in Health Care (2011)

Few years ago, the information flow in health care field was relatively simple and the application of technology was limited. However, as we progress into a more integrated world where technology has become an integral part of the business processes, the process of transfer of information has become more complicated. There has already been a long standing tradition for computer-based decision support, dealing with complex problems in medicine such as diagnosing disease, managerial decisions and assisting in the prescription of appropriate treatment. Today, one of the biggest challenges that health care system, face is the explosive growth of data, use this data to improve the quality of managerial decisions. Web mining and Data mining techniques are analytical tools that can be used to extract meaningful knowledge from large data sets. This paper addresses the applications of web mining and data mining in health care management system to extract useful information from the huge data sets and providing analytical tool to view and use this information for decision making processes by taking real life examples. Further we propose the IDSS model for the health care so that exact and accurate decision can be taken for the removal of a particular disease.
Primer on the Immune System (2015)

The human body regularly encounters and combats many pathogenic organisms and toxic molecules. Its ensuing responses to these disease-causing agents involve two interrelated systems: innate immunity and adaptive (or acquired) immunity. Innate immunity is active at several levels, both at potential points of entry and inside the body (see figure). For example, the skin represents a physical barrier preventing pathogens from invading internal tissues. Digestive enzymes destroy microbes that enter the stomach with food. Macrophages and lymphocytes, equipped with molecular detectors, such as Toll-like receptors (TLRs), which latch onto foreign structures and activate cellular defenses, patrol the inside of the body. These immune cells sense and devour microbes, damaged cells, and other foreign materials in the body. Certain proteins in the blood (such as proteins of the complement system and those released by natural killer cells, along with antimicrobial host-defense peptides) attach to foreign organisms and toxins to initiate their destruction.
Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells. (1994)

Optimal T-cell activation requires both an antigen-specific signal delivered through the T-cell receptor and a costimulatory signal which can be delivered through the CD28 molecule. CD28 costimulation induces the expression of multiple lymphokines, including interleukin 2 (IL-2). Because the c-Rel transcription factor bound to and activated the CD28 response element within the IL-2 promoter, we focused our study on the mechanism of CD28-mediated regulation of c-Rel in human peripheral blood T cells. We showed that CD28 costimulation accelerated the kinetics of nuclear translocation of c-Rel (and its phosphorylated form), p50 (NFKB1), and p65 (RelA). The enhanced nuclear translocation of c-Rel correlated with the stimulation of Il-2 production and T-cell proliferation by several distinct anti-CD28 monoclonal antibodies. This is explained at least in part by the long-term downregulation of I kappa B alpha following CD28 signalling as opposed to phorbol myristate acetate alone. Furthermore, we showed that the c-Rel-containing CD28-responsive complex is enhanced by, but not specific to, CD28 costimulation. Our results indicate that c-Rel is one of the transcription factors targeted by CD28 signalling.
Distributed Metric Calibration of Large Camera Networks (2004)

Motivated by applications in surveillance sensor networks, we present a distributed algorithm for the automatic, external, metric calibration of a network of cameras with no centralized processor. We model the set of uncalibrated cameras as nodes in a communication network, and propose a distributed algorithm in which each camera only communicates with other cameras that image some of the same scene points. Each node independently forms a neighborhood cluster on which the local calibration takes place, and calibrated nodes and scene points are incrementally merged into a common coordinate frame. The accurate performance of the algorithm is illustrated using examples that model real-world sensor networking situations.
Synthesis of a Peptidomimetic Analog of the Binding Domain of Rapamycin (1997)

Abstract Stereoselective synthesis of a peptidomimetic analog of the binding domain of rapamycin starting from N,N-dibenzyl-R-alaninal is described.
Hunting for Organic Molecules with Artificial Intelligence: Molecules Optimized for Desired Excitation Energies (2018)

This work presents a proof-of-concept study in artificial-intelligence-assisted (AI-assisted) chemistry where a machine-learning-based molecule generator is coupled with density functional theory (DFT) calculations, synthesis, and measurement. Although deep-learning-based molecule generators have shown promise, it is unclear to what extent they can be useful in real-world materials development. To assess the reliability of AI-assisted chemistry, we prepared a platform using a molecule generator and a DFT simulator, and attempted to generate novel photofunctional molecules whose lowest excited states lie at desired energetic levels. A 10 day run on the 12-core server discovered 86 potential photofunctional molecules around target lowest excitation levels, designated as 200, 300, 400, 500, and 600 nm. Among the molecules discovered, six were synthesized, and five were confirmed to reproduce DFT predictions in ultraviolet visible absorption measurements. This result shows the potential of AI-assisted chemistry to discover ready-to-synthesize novel molecules with modest computational resources.
Possible Detection of Pancreatic Cancer by Plasma Protein Profiling (2005)

The survival rate of pancreatic cancer patients is the lowest among those with common solid tumors, and early detection is one of the most feasible means of improving outcomes. We compared plasma proteomes between pancreatic cancer patients and sex- and age-matched healthy controls using surface-enhanced laser desorption/ionization coupled with hybrid quadrupole time-of-flight mass spectrometry. Proteomic spectra were generated from a total of 245 plasma samples obtained from two institutes. A discriminating proteomic pattern was extracted from a training cohort (71 pancreatic cancer patients and 71 healthy controls) using a support vector machine learning algorithm and was applied to two validation cohorts. We recognized a set of four mass peaks at 8,766, 17,272, 28,080, and 14,779 m/z, whose mean intensities differed significantly (Mann-Whitney U test, P < 0.01), as most accurately discriminating cancer patients from healthy controls in the training cohort [sensitivity of 97.2% (69 of 71), specificity of 94.4% (67 of 71), and area under the curve value of 0.978]. This set discriminated cancer patients in the first validation cohort with a sensitivity of 90.9% (30 of 33) and a specificity of 91.1% (41 of 45), and its discriminating capacity was further validated in an independent cohort at a second institution. When combined with CA19-9, 100% (29 of 29 patients) of pancreatic cancers, including early-stage (stages I and II) tumors, were detected. Although a multi-institutional large-scale study will be necessary to confirm clinical significance, the biomarker set identified in this study may be applicable to using plasma samples to diagnose pancreatic cancer.
Limited protection by small unilamellar liposomes against the renal tubular toxicity induced by repeated amphotericin B infusions in rats (1991)

Amphotericin B (AMB), either alone or incorporated into small unilamellar vesicles of pure dipalmitoylphosphatidyl choline (DPPC SUV-AMB), was administered intravenously to male Sprague-Dawley rats once daily for 5 days. Either 1.5 or 3.5 mg of AMB or DPPC SUV-AMB per kg was given, since these concentrations corresponded, respectively, to the lowest nephrotoxic dose and the sublethal dose of AMB in our model. Tubular functions were evaluated daily, and AMB concentrations in plasma, urine, and tissues were measured by high-performance liquid chromatography. AMB at both doses induced tubular toxicity, hyposthenuria being the earliest symptom. DPPC SUV-AMB at 1.5 mg/kg/day was atoxic, but the tubular alterations induced by 3.5 mg of DPPC SUV-AMB per kg were similar to those observed with 3.5 mg of AMB per kg, except that the ability to concentrate urine was partly restored 72 h after the last infusion. Incorporating AMB into DPPC SUV did not influence the pharmacokinetics of the drug. Using this lipidic AMB formulation, we thus observed a beneficial effect toward limiting the renal tubular toxicity of repeated low doses of AMB but, unexpectedly, not that of high doses. These results indicate that tubular renal functions and electrolyte serum values should be closely monitored in patients treated with AMB liposomal formulations, especially high-dose regimens.
Research activities on antennas in SAMEER (2008)

Summary form only given. Design and characterization of antennas at various frequency bands, is one of the main activities of SAMEER. Thus, developmental work on antennas are carried out at all the three centers of SAMEER, which are located at Mumbai, Chenai and Kolkata. Different types of antennas for various sponsored and core R&D projects have been developed for the frequency range starting from HF to millimeter wave frequency. All kinds of antennas, such as wire (element as well as array), slotted antenna array, horn antennas (both standard as well as ridge), helical antennas (normal, axial and printed), loop antennas, blade and air borne antennas, conformal (microstrip and suspended) antennas, reflector antennas, etc have been developed. Keeping in tune with the fast growing technology, most recent types such as; UWB antennas, Fractal antennas, reflect-array antennas, space fed antennas, active antennas, reconfigurable antennas, frequency selective surface, etc have also been designed and developed. All these work on antennas will be covered in the invited talk.
Increased Susceptibility to Colitis-Associated Cancer of Mice Lacking <i>TIR8</i>, an Inhibitory Member of the Interleukin-1 Receptor Family (2007)

TIR8 (also known as SIGIRR) is a member of the interleukin-1/Toll-like receptor family with inhibitory activity on inflammatory reactions and high expression in intestinal mucosa. Here, we report that Tir8-deficient mice exhibited a dramatic intestinal inflammation in response to dextran sulfate sodium salt (DSS) administration in terms of weight loss, intestinal bleeding, and mortality and showed increased susceptibility to carcinogenesis in response to azoxymethane and DSS. Increased susceptibility to colitis-associated cancer was associated to increased permeability and local production of prostaglandin E(2), proinflammatory cytokines, and chemokines. Thus, these results are consistent with the hypothesis that TIR8, by negatively regulating intestinal inflammation, plays a nonredundant role in the control of the protumor activity of chronic inflammation in the gut.
Leptin Increases the Viability of Isolated Rat Pancreatic Islets by Suppressing Apoptosis (2001)

To test the hypothesis that leptin secreted from adipose tissue is a mediator linking obesity and pancreatic islet hypertrophy, we examined the effects of leptin on proliferative and apoptotic responses in rat islet cells. Rat pancreatic islets were isolated and incubated with 0, 1, 5, or 75 nM leptin for 24 h under serum-deprived conditions. Cell viability was assessed with 2,5-diphenyltetrazolium bromide and trypan blue dye exclusion tests. Cell proliferation and apoptosis were evaluated with 5-bromo-2'-deoxyuridine incorporation into DNA and DNA ladder formation, respectively. Incubation for 24 h with 1 and 5 nM leptin, the concentrations observed in obese subjects, increased the viability of isolated pancreatic islet cells. Five nanomolar concentrations of leptin did not stimulate 5-bromo-2'-deoxyuridine incorporation into incubated islet cells, indicating no influence on cell proliferation, but did inhibit DNA ladder formation, a hallmark of cell apoptosis. Moreover, 5 nM leptin reduced the triglyceride content and suppressed inducible nitric oxide synthase mRNA expression in incubated islets. These results suggest that leptin increased viable cell numbers via suppression of apoptosis in isolated pancreatic islet cells under these experimental conditions. This mechanism might account at least in part for an obesity-induced increase in pancreatic beta-cell mass.
Direitos fundamentais e orientação sexual : o direito brasileiro e a homossexualidade (1998)

Examina, de modo sistematico e a luz do ordenamento juridico constitucional, a pertinencia da orientacao sexual ? com enfase na homossexualidade ? ao catalogo dos direitos fundamentais e ao principio da dignidade da pessoa humana. Para tanto, alem da posicao do tema nas chamadas geracoes de direitos humanos, sao analisadas especificamente as clausulas constitucionais da dignidade da pessoa humana, da igualdade e da privacidade, mediante uma interpretacao do Direito brasileiro informada pelos precedentes do Direito norte-americano, canadense e europeu.
Gas Balancing Rules Must Take into Account the Trade-off between Offering Pipeline Transport and Pipeline Flexibility in Liberalized Gas Markets (2010)

Loyola de Palacio Programme on Energy Policy
Using Smartphones to Monitor Cycling and Automatically Detect Accidents - Towards eCall Functionality for Cyclists (2014)

Automatic crash notification to the nearest emergency center in case of a traffic accident will\nthrough the EU initiative eCall improve the safety for cars on European roads. eCall functionality\ncould also increase the safety for vulnerable road users such as cyclists, but there is no\ntechnical implementation agreed upon for this purpose. We propose to use smartphones due to\ntheir widespread availability and no need for extra hardware. Today’s high-end smartphones are\nequipped with both GPS functionality and movement sensors. The aims of this study were to\nexplore if smartphones can be used to collect cycling data of sufficient quality and to design and\nevaluate a crash detection algorithm (CDA) for cycling accidents. A Google Nexus 4 smartphone\nwas chosen for the study. This device is equipped with a combined accelerometer and gyroscope\nchip. Over five hours of “normal” cycling data, i.e. without accidents/incidents, was collected. Six\ncrash tests were performed using a simplified crash test dummy. In order to achieve a realistic\nuser scenario the smartphone was allowed to be easily carried as in everyday use, i.e. the users\nwere not required to fix it to the body. We used the total acceleration based on the sum of square\nof each direction to obtain a measure independent on smartphone orientation. For normal cycling\nthis measure was found to momentarily be as high as 50 ms2. High levels were often due to\nhandling of the smartphone. This prompted that an acceleration threshold alone is not sufficient\nfor an accurate CDA. A marked rotation during a short time interval was found to be an important\npredictor for crashes. An accurate CDA was designed based on a combination of sensor data such\nas acceleration and rotation. The CDA detected all crashes and was subsequently evaluated in\nseveral hours of normal cycling without any false positive alarms.