gebhart/patrepeval huggingface dataset:
Dynamically linked domain-specific extensions for advice languages (2008)

Domain-specific aspect languages allow defining aspects for a certain problem domain faster and easier by providing specialized expressivity and by reducing the complexity of the language interface. However, providing domain-specific aspect languages is a rather complex task. With current approaches only specialists can build new domain specific aspect languages; in doing so they have to replicate large parts of the tool set. In this paper, we have extended a general-purpose aspect language to support embedded domain-specific syntax in the advice language. The approach has several advantages. First, it allows reusing a large part of existing tools and infrastructure. Second domain-specific extensions can be defined in separated modules, which can be dynamically linked into the advice language; these modules can be inherited from, they can be refined from existing implementations, and can be composed to support abstractions from different domains.
Colombia en el Caribe (2006)

Notch-Delta signaling is indispensable for somitogenesis, which controls the vertebrate segmentation during embryonic development. Several theoretical models have been proposed to explain this interesting process. In zebrafish somitogenesis, genes her1, her7, delta, and their proteins plays the important roles. However, an auto-repression model with time delay involved only by her1/her7 is able to explain zebrafish somitogenesis. This paper will systematically study the dynamics of this model. Specifically we investigate its stability, bifurcation (oscillation), and stability of oscillation. First, the conditions for both stability and bifurcation are presented based on the linearized model. Then three indices for bifurcation of this nonlinear model are derived by using linear functional operator analysis. Finally, the numerical simulations are carried out to illustrate the theoretical results developed in this study.
Identification of fetal unmodified and 5-hydroxymethylated CG sites in maternal cell-free DNA for non-invasive prenatal testing (2020)

uTOP-seq and hmTOP-seq approaches provide a cost-efficient and sensitive epigenetic analysis of fetal abnormalities in maternal cfDNA. The results demonstrated that T21 fetuses contain a perturbed epigenome and also indicated that fetal cfDNA might originate from fetal tissues other than placental chorionic villi. Robust covalent derivatization followed by targeted analysis of fetal DNA by sequencing or qPCR presents an attractive strategy that could help achieve superior sensitivity and specificity in prenatal diagnostics.
An all-capacitive sensing chip for temperature, absolute pressure, and relative humidity (2004)

This paper presents an all-capacitive sensing chip for temperature, absolute pressure, and relative humidity. The temperature sensors are based on a Si/Au bimorph structure contacting a fixed electrode and produce a sensitivity of 14fF//spl deg/C from 20 to 100/spl deg/C. The absolute pressure sensors have a sensitivity of 15fF/Torr and can be combined to span 500-1200Torr. The relative humidity sensor responds with 39fF/%RH from 20-95%RH. The three-transducer chip uses a bulk- and surface- micromachined silicon-on-glass process and combines anodic bonding with silicon/gold eutectic solder to realize vacuum-sealed cavities along with low-impedance (6/spl Omega/) electrical feedthroughs.
Leistungsanalyse der Zugriffsmethode VSAM (1985)

Description d'un choix de fonction de la methode d'acces VSAM largement utilise a partir d'IBM
Mood Based Music Categorization System for Bollywood Music (2014)

Music shares a very special relation with human emotions. We often choose to listen to a song or music which best fits our mood at that instant. In spite of this strong correlation, most of the music applications today are devoid of providing the facility of mood-aware playlist generation. We wish to contribute to automatic identification of mood in audio songs by utilizing their spectral and temporal audio features. Our current work involves analysis of various features in order to learn, train and test the model representing the moods of the audio songs. Focus of our work is on the Indian popular music pieces and our work continues to analyse, develop and improve the algorithms to produce a system to recognize the mood category of the audio files automatically.
The Chemi-Ionization Detector: A Flameless Ionization Detector (1970)

Journal Article The Chemi-Ionization Detector: A Flameless Ionization Detector Get access Martin Scolnick Martin Scolnick Varian Aerograph, 2700 Mitchell Drive, Walnut Creek, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Chromatographic Science, Volume 8, Issue 8, August 1970, Pages 462–466, https://doi.org/10.1093/chromsci/8.8.462 Published: 01 August 1970 Article history Received: 22 April 1970 Published: 01 August 1970
Towards Profitable Virtual Machine Placement in the Data Center (2011)

Motivated by the limit on the power usage effectiveness (PUE) of the data centers, the potential benefit of the consolidation, and the impetus of achieving maximum return on investment (ROI) on the cloud computing market, we investigate VM placement in the data center, formulate a multi-level generalized assignment problem (MGAP) for maximizing the profit under the service level agreement and the power budget constraint based on the model of a virtualized data center, and solve it with a first-fit heuristic. Numerical simulations show that the first-fit heuristic is effective in solving the large-scale instances of the MGAP with the sampled simulation setups.
Multicomponent ocean bottom and vertical cable seismic acquisition for wavefield reconstruction (2010)

Abstract In ocean-bottom seismic and vertical-cable surveying, receiver stations are stationary on the sea floor while a source vessel shoots on a predetermined x-y grid on the sea surface. To reduce exploration cost, the shot point interval often is so coarse that the data recorded at a given receiver station are undersampled and thus irrecoverably aliased. However, when the pressure field and its x- and y-derivatives are measured in the water column, the nonaliased pressure field can be reconstructed by interpolation. Likewise, if the vertical component of the particle velocity (or acceleration) and its x- and y-derivatives are measured, then this component can also be reconstructed by interpolation. The interpolation scheme can be any scheme that reconstructs the field from its sampled values and sampled derivatives. In the case that the two fields' first-order derivatives are recorded, the total number of components is six. When also their second-order derivatives are measured, the number of components is 10. The properly interpolated measurements of pressure and vertical component of particle velocity from the multicomponent measurements allow true 3D up/down wavefield decomposition (deghosting) and wave-equation demultiple before wave-equation migration.
Efficient monochromator to isolate VUV light generated by four-wave mixing techniques (1988)

The lateral chromatic aberration from a LiF lens, which is positioned off-axis with respect to the incident light beams, is used to isolate the VUV light generated by the four-wave mixing technique from the intense pump light. The transmittance of the monochromator at the VUV wavelength is limited by the transmittance of a single lens. The ratio of transmitted-to-incident pump energy is 3.3 x 10(-6). A single monochromator with two interchangeable lenses can be used for either tightly focused or collimated pump beams.
Retinal Pathway Origins of the Pattern Electroretinogram (PERG) (2011)

Transient PERG receives nearly equal amplitude contributions from ON and OFF pathways. N95 reflects spiking activity of ganglion cells; P50 reflects nonspiking activity as well. Steady state PERG, in contrast, reflects mainly spike-related ON pathway activity.
State of the Art in Miniaturized Separation Techniques (2002)

Miniaturized separation techniques have become very attractive recently because they offer a number of advantages over classic ones, for example, reduced chemicals consumption, separation improvement, and better sensitivity. It is also very important that they require minute samples, which is very often of primary importance in the environmental or biomedical sciences. In general, miniaturized systems that are being developed currently are divided into column and chip ones. For best performance of the separation microsystem, it must be properly designed in the terms of volumes and shapes of the parts it consists of. Theoretical considerations present this problem. As column systems are better known and understood the microcolumns are more frequently developed. Current works are focused on the preparation of unified columns that can be used in various techniques — for example, in micro-HPLC and CEC. Because of problems occurring in packed capillary column preparation and utilization, monolithic (rod) columns are developed to overcome the problems of inhomogeneity of packing or bubble formation under electroosmotic flow conditions. The requirements of minute sample analysis have been resolved by the construction of chip devices originating from total analysis system (TAS). Such systems are primarily designed for zone electrophoresis separations; however, micellar electrokinetic chromatography, gel chromatography, electrochromatography, or liquid chromatography can be performed using a chip device. In this article the most important trends in miniaturization of the separation systems are discussed, including theory, system preparation, and performance as well as exemplary applications.
Effect of Male Sex and Obesity on Platelet Arachidonic Acid in Spontaneous Hypertensive Heart Failure Rats (2004)

Sexual dimorphism is observed in the progression to congestive heart failure and, ultimately, in longevity in spontaneously hypertensive heart failure (SHHF) rats. As platelet activation may impact development of cardiovascular diseases, we studied the effects of obesity and sex on platelet polyunsaturated fatty acid (PUFA) profile and its relationship to platelet aggregation in 6-month-old SHHF rats. After a 24-hr fast, blood was obtained for measurement of platelet phospholipid omega-6 (n-6) and omega-3 (n-3) PUFA. Collagen-induced platelet aggregation was measured by whole-blood impedance aggregometry. Obese male (OM) SHHF had significantly more platelet arachidonic acid (AA) and total n-6 PUFA than lean males (LMs), lean females (LFs), or obese females (OFs). Platelet aggregation was enhanced in males compared to females, with OMs by 45% compared to OFs and with LMs by 28% compared to LFs. Though no difference was found between OFs and LFs, platelet aggregation was increased in OMs by 20% compared to LMs. Though not significantly different, lag time to initiate platelet aggregation tended to be shortest in OMs and then, in increasing duration, LMs, LFs, and OFs, suggesting that platelets from male rats were quicker to aggregate than those from females. Platelet aggregation was correlated with platelet AA and total n-6 PUFA content. There was no relationship between n-3 PUFA and platelet aggregation. In SHHF rats, elevated AA and n-6 PUFA levels in platelets are associated with enhanced platelet aggregation. This relationship is potentiated by obesity and male sex.
Power efficiency improvement in a tandem organic light-emitting diode (2008)

When a tandem light-emitting diode (OLED) utilizes unoptimized electroluminescent (EL) units, it is fairly easy to improve the power efficiency of such a device. However, when a tandem OLED utilizes optimized EL units, improved power efficiency can only be achieved if each intermediate connector has excellent carrier injection capabilities along with a negligible voltage drop across it. Four organic intermediate connectors were studied in this work, one of which consisting of a Li-doped 4,7-diphenyl-1,10-phenanthroline layer and a 1,4,5,8,9,11-hexaazatriphenylene hexacarbonitrile layer, exhibits the best power efficiency improvement for tandem OLEDs.
Prenylated Stilbenes and Their Novel Biogenetic Derivatives from <i>Artocarpus chama</i> (2006)

Abstract Two new prenylated stilbenes, artochamins F ( 1 ) and G ( 2 ), and their four novel derivatives, artochamins H–K ( 3 – 6 ), were isolated from the stems of Artocarpus chama . Their structures were elucidated mainly by NMR spectroscopy and mass spectrometry. The structure of 3 was confirmed by X‐ray crystallographic analysis. The origin of 3 – 6 could be assumed biogenetically from 2 . The cytotoxicity of these compounds against HepG2 cells was evaluated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Analysis of the putative role of 24‐carbon polyunsaturated fatty acids in the biosynthesis of docosapentaenoic (22:5<i>n</i>‐6) and docosahexaenoic (22:6<i>n</i>‐3) acids (1998)

The recent literature on the putative involvement of a single cycle of peroxisomal beta-oxidation of 24:5n-6 and 24:6n-3 polyunsaturated fatty acids in the biosynthesis of the respective docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) fatty acids is critically reviewed. Present evidence suggests that in vitro data in support of the above proposition is an artifact of a low 2,4-dienoyl-CoA reductase activity due to depletion of NADPH resulting from incubation conditions. Kinetic studies with radiolabeled precursors in cell cultures have shown lower initial rates of labeling of 24:6n-3 than that of 22:6n-3, indicating that 24:6n-3 is an elongation product of 22:6n-3 rather than its precursor. Analysis of other literature data supports the proposal that 22:5n-6 and 22:6n-3 are synthesized in mitochondria via channeled carnitine-dependent pathways involving separate n-6- and n-3-specific desaturases. It is proposed that impaired peroxisomal function in some peroxisomal disorders is a secondary consequence of defective mitochondrial synthesis of 22:6n-3; moreover, some disorders of peroxisomal beta-oxidation show normal or increased 22:5n-6 concentrations, indicating that 22:5n-6 is synthesized by independent desaturases without peroxisomal involvement.
Retinex in Matlab. (2000)

Many different descriptions of Retinex methods of light- ness computation exist. We provide concise MATLAB™ implemen- tations of two of the spatial techniques of making pixel comparisons. The code is presented, along with test results on several images and a discussion of the results. We also discuss the calibration of input images and the postRetinex processing required to display the output images. © 2004 SPIE and IS&T. (DOI: 10.1117/1.1636761)
The Role of Mechanoreceptive Information in the Stability of Human Upright Posture: A Theoretical Consideration (1997)

This study examined the role of feedback from cutaneous mechanoreceptors in the stability of human upright posture. A two-link, one degree of freedom, inverted pendulum model was constructed for the human body with ankle joint torque proportional to the delayed outputs from muscle receptors, joint receptors, and cutaneous mechanoreceptors in the foot. Theoretical analysis and numerical simulations indicated that the use of mechanoreceptive information reduced the frequency range and the maximum peak-peak value of the dynamic response of the system. However, without the use of muscle receptors, the mechanoreceptive feedback could not stabilize the system. In addition, body movement of human subjects was measured when their balanced upright posture was disturbed by a transient, forward/backward movement of a supporting platform. The loss of or change in cutaneous mechanoreceptive sense in their feet was induced by (a) having healthy subjects stand on a soft surface and (b) testing neuropathic patients with loss of vibratory sensation in their feet. The results showed significant increases in frequency range and maximum peak-peak value of ankle rotation and velocity for subjects standing on a soft (vs. hard) surface and for neuropathic patients (vs. age- and gender-matched healthy subjects).
A Phenomenological Model for Predicting Melting Temperatures of DNA Sequences (2010)

We report here a novel method for predicting melting temperatures of DNA sequences based on a molecular-level hypothesis on the phenomena underlying the thermal denaturation of DNA. The model presented here attempts to quantify the energetic components stabilizing the structure of DNA such as base pairing, stacking, and ionic environment which are partially disrupted during the process of thermal denaturation. The model gives a Pearson product-moment correlation coefficient (r) of approximately 0.98 between experimental and predicted melting temperatures for over 300 sequences of varying lengths ranging from 15-mers to genomic level and at different salt concentrations. The approach is implemented as a web tool (www.scfbio-iitd.res.in/chemgenome/Tm_predictor.jsp) for the prediction of melting temperatures of DNA sequences.
Forage Chopping Energy vs. Length of Cut (1989)

ABSTRACT Acylinder type forage harvester was used to cut forage at 6.3, 12.7, 25.4 and 38.1 mm theoretical length of cut. Experimental data was used to develop a predictive model of energy versus length of cut and moisture content. Energy savings of 22% at the power take-off shaft were predicted at the longest length. Additional energy savings up to 31% were observed in drier crops at 62% moisture compared with 83% moisture. Chopping at 38 mm theoretical length required 15% less tractor power than chopping at 6 mm length to meet peak power demand. Actual fuel savings at the longest length of cut under normal field operations were not as much as the average power reduction measured at the PTO shaft and were confounded with operating speed, yield and moisture content.
High yield sub-0.1&#x00B5;m<sup>2</sup> 6T-SRAM cells, featuring high-k/metal-gate finfet devices, double gate patterning, a novel fin etch strategy, full-field EUV lithography and optimized junction design &amp; layout (2010)

We report high yield sub-0.1μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> SRAM cells using high-k/metal gate FinFET devices. Key features are (1) novel fin patterning strategy, (2) double gate patterning (3) new SRAM cell layout and (4) EUV lithography and robust etch/fill/CMP for contact/metal 1.0.099μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> FinFET 6T-SRAM cells show good yield. And smaller cells (0.089μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) are functional. Further yield improvement is possible by junction optimization using extension less junction approach and further cell layout optimization.
A Fast, Compact Approximation of the Exponential Function (1999)

Neural network simulations often spend a large proportion of their time computing exponential functions. Since the exponentiation routines of typical math libraries are rather slow, their replacement with a fast approximation can greatly reduce the overall computation time. This article describes how exponentiation can be approximated by manipulating the components of a standard (IEEE-754) floating-point representation. This models the exponential function as well as a lookup table with linear interpolation, but is significantly faster and more compact.
Targeting AKT Signaling in Pediatric Acute Lymphoblastic Leukemia with Sulforaphane (2011)

Abstract Abstract 1521 Refractory and relapse acute lymphoblastic leukemia (ALL) is one of the leading causes of cancer-related death in children. Novel agents are still in need as a frontline therapy in high risk patients and salvage agent in relapse patients. Leukemic cells acquire a survival advantage over normal blood cells by losing control of the cell cycle and activating pro-survival signals. There are emerging evidences showing that the PI3K/AKT/mTOR pathway is frequently activated in both T cell acute lymphoblastic leukemia (T-ALL) and precursor B cell acute lymphoblastic leukemia (pre-B ALL) (approximately 30% of ALL patients). Thus, drugs able to inhibit AKT signaling are potential candidates for ALL treatment. Sulforaphane (SF) is a dietary compound found in cruciferous vegetables with well-known chemopreventive and chemotherapeutic function in solid tumors by inducing apoptosis and inhibiting survival and cell division. However, the anti-leukemic capacity of SF in hematologic malignancies has not been extensively investigated. In this study, we found increased cleavage of PARP, caspase-3, caspase-8 and caspase-9 by immunoblots in pre-B and T-ALL cell lines treated with SF (5–10 μM) for 24 –48 hours. In addition, we detected increased expression of p21 and cyclin B that correlated with a G2/M block and DNA damage observed in SF treated cells by analysis of DNA content and H2AXγ expression. Noteworthy, SF-treated pre-B and T-ALL cell lines exhibit lower levels of total and phosphorylated AKT in addition to decreased levels of total and phosphorylated mTOR, which was independent of p53 and PTEN activities. Lower survival signals upon SF treatment correlated with a dose- and time-dependent cytotoxicity in pre-B ALL cell lines (Nalm-6, REH and RS-4) and T-ALL cell lines (Jurkat, RPMI, DND-41 and KOPTK1) compared to EBV-transformed lymphoblasts used as a control. Interestingly, SF showed a synergistic effect with vincristine in pre-B and T-ALL cell lines, suggesting a potential use of SF in adjunctive therapy. Aiming to support future clinical trials, we confirmed that SF is effective in lymphoblasts from pediatric patients suffering with ALL, both pre-B and T, in a time- and dose-dependent manner (95% confidence interval IC50: pre-B ALL = 9.9 – 12.13 μM, T-ALL = 8.3 –11.00 μM). To investigate whether SF is effective in vivo in a xenograft mouse model, we injected nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice with Nalm-6 cells transduced with GFP-FFluc for bioluminescent imaging detection. SF treatment (2 mg i.p. daily) significantly reduced tumor burden compared to the control group (injected with vehicle). Collectively, our data show that SF has anti-leukemic properties in ALL, both in primary samples from patients and cell lines, by inducing cell death selectively in leukemic cells likely by inhibiting AKT-dependent survival signals. Disclosures: No relevant conflicts of interest to declare.
Noncontact monitoring of surface-wave nonlinearity for predicting the remaining life of fatigued steels (2001)

A nonlinear acoustic measurement is studied for fatigue damage monitoring. An electromagnetic acoustic transducer (EMAT) magnetostrictively couples to a surface-shear-wave resonance along the circumference of a rod specimen during rotating bending fatigue of carbon steels. Excitation of the EMAT at half of the resonance frequency caused the standing wave to contain only the second-harmonic component, which was received by the same EMAT to determine the second-harmonic amplitude. Thus measured surface-wave nonlinearity always showed two distinct peaks at 60% and 85% of the total life. We attribute the earlier peak to crack nucleation and growth, and the later peak to an increase of free dislocations associated with crack extension in the final stage. This noncontact resonance-EMAT measurement can monitor the evolution of the surface-shear-wave nonlinearity throughout the metal’s fatigue life and detect the pertinent precursors of the eventual failure.