gebhart/patrepeval huggingface dataset:
Obesity and Cardiovascular Disease Risk: Research Update (2001)

The obesity epidemic has reached unprecedented proportions in Western society. Evidence continues to accumulate that obesity is associated with significant morbidity and mortality and in particular that it is an independent risk factor for cardiovascular disease (CVD). The association of obesity with CVD and its risk factors, including hypertension, dyslipidemia, glucose intolerance, and impaired hemostasis is becoming more clearly understood. An increasing body of data indicates that risk factors tend to cluster in obese individuals and may act synergistically to increase these people's risk for CVD. Individuals with disproportionate visceral adiposity are at significantly greater risk for CVD. Adult weight gain also underlies the development of many risk factors and augments the risk of CVD. Physicians can play a vital and active role in the prevention and treatment of obesity and overweight and thereby reduce patients' CVD risk.
Experimental Evidence of Self-Localized and Propagating Spin Wave Modes in Obliquely Magnetized Current-Driven Nanocontacts (2010)

Through detailed experimental studies of the angular dependence of spin wave excitations in nanocontact-based spin-torque oscillators, we demonstrate that two distinct spin wave modes can be excited, with different frequency, threshold currents, and frequency tunability. Using analytical theory and micromagnetic simulations we identify one mode as an exchange-dominated propagating spin wave, and the other as a self-localized nonlinear spin wave bullet. Wavelet-based analysis of the simulations indicates that the apparent simultaneous excitation of both modes results from rapid mode hopping induced by the Oersted field.
Control of centrosome reproduction: The right number at the right time (1999)

It is of great importance for the cell to precisely coordinate the doubling of the interphase centrosome with nuclear events during the cell cycle and limit the number of centrosomes it contains at the onset of mitosis to two and only two. The penalties for mistakes are abnormal spindle assembly, inappropriate chromosome distribution, and consequently, genomic instability. We review the functional properties of the mechanisms that control when the centrosome duplicates in the cell cycle and the controls for centrosome copy number. We look to limits that are intrinsic to the centrosome itself and controls imposed by cell cycle linked changes in cytoplasmic conditions. Control of centrosome reproduction is exercised at both levels.
Internet X.509 Public Key Infrastructure Representation of Key Exchange Algorithm (KEA) Keys in Internet X.509 Public Key Infrastructure Certificates (1999)

The Key Exchange Algorithm (KEA) is a classified algorithm for exchanging keys. This specification profiles the format and semantics of fields in X.509 V3 certificates containing KEA keys. The specification addresses the subjectPublicKeyInfo field and the keyUsage extension.
40-Gbit/s dispersion-managed soliton transmission over 3000 km of standard fiber through optimization of the dispersion map parameters (2000)

Summary form only given.The use of dispersion management has been shown to allow the transmission of data at 40 Gbit/s over distances greater than 1000 km in standard fiber. In this regime, it becomes difficult to find the optimal parameters to allow the maximum transmission distance. Here, we introduce a simple numerical technique to find the best average dispersion and input pulse chirp. Using the optimized parameters we form a numerical model allowing transmission of data over 3000 km of dispersion-managed standard fiber.
Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells. (1990)

Growth factor activation of serine/threonine protein kinases was studied by treating quiescent Swiss 3T3 cells with epidermal growth factor (EGF) and examining cytosolic extracts for protein kinase activity under conditions inhibitory to calcium- and cyclic nucleotide-dependent kinases. Cytosolic extracts of cells stimulated for 5 min were fractionated by Mono Q fast protein liquid chromatography. Eight peaks of kinase activity were resolved, of which five were stimulated by EGF treatment of cells. These peaks were revealed using the synthetic peptide Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala (S6 peptide), 40 S ribosomal S6 protein, glycogen synthase, microtubule-associated protein 2, and myelin basic protein as substrates. The peaks varied in the kinetics of their activation by EGF and in their response to insulin. Selected peaks were resolved further by sizing gel chromatography. The results together indicate that at least seven distinct fractions of cytosolic kinase activities are stimulated in Swiss 3T3 cells by EGF. One of these, which phosphorylates both S6 protein and S6 peptide, is similar to the S6 kinase characterized previously in this cell line by others. Four additional activities that also phosphorylate the S6 protein and S6 peptide appear unrelated to this enzyme. Finally, two kinase activities that phosphorylate both myelin basic protein and microtubule associated protein 2 are EGF stimulated. One is similar to an insulin-stimulated microtubule-associated protein 2 kinase described in other cell lines whereas the other seems to represent a novel activity. Several of these EGF-stimulated activities were inactivated by protein phosphatases, suggesting that they might be regulated by phosphorylation.
Drug-Induced Hepatotoxicity (1986)

Drug-induced injury to the liver can mimic any form of acute or chronic liver disease. Acute injury to the liver frequently is due to the action of cytochrome P450, which breaks down drugs into electrophiles or free radicals; these reactive metabolites can covalently bind to protein and unsaturated fatty acids or induce lipid peroxidation, respectively. These events may impair vital functions of the cell, such as maintenance of calcium homeostasis, leading to death; or hypothetically they may elicit a hypersensitivity reaction directed mainly at the liver. Glutathione and tocopherol play critical roles in cellular defense. Cholestatic disease caused by drugs results from a selective disturbance in bile secretion. Agents such as estrogens, chlorpromazine, and monohydroxy bile acids alter the chemical and physical properties of membranes, leading to impaired activity of carriers and pumps for bile acids and electrolytes. Certain drugs produce chronic liver disease that is pathologically identical to chronic active hepatitis, biliary cirrhosis, or alcoholic liver disease.
Thermal conductivity of graphene nanoribbons in noble gaseous environments (2014)

We investigate the thermal conductivity of suspended graphene nanoribbons in noble gaseous environments using molecular dynamics simulations. It is reported that the thermal conductivity of perfect graphene nanoribbons decreases with the gaseous pressure. The decreasing is more obvious for the noble gas with large atomic number. However, the gaseous pressure cannot change the thermal conductivity of defective graphene nanoribbons apparently. The phonon spectra of graphene nanoribbons are also provided to give corresponding supports.
Pancreatic Ductal Morphogenesis and the Pdx1 Homeodomain Transcription Factor (2009)

Embryonic development of the pancreas is marked by an early phase of dramatic morphogenesis, in which pluripotent progenitor cells of the developing pancreatic epithelium give rise to the full array of mature exocrine and endocrine cell types. The genetic determinants of acinar and islet cell lineages are somewhat well defined; however, the molecular mechanisms directing ductal formation and differentiation remain to be elucidated. The complex ductal architecture of the pancreas is established by a reiterative program of progenitor cell expansion and migration known as branching morphogenesis, or tubulogenesis, which proceeds in mouse development concomitantly with peak Pdx1 transcription factor expression. We therefore evaluated Pdx1 expression with respect to lineage-specific markers in embryonic sections of the pancreas spanning this critical period of duct formation and discovered an unexpected population of nonislet Pdx1-positive cells displaying physical traits of branching. We then established a 3D cell culture model of branching morphogenesis using primary pancreatic duct cells and identified a transient surge of Pdx1 expression exclusive to branching cells. From these observations we propose that Pdx1 might be involved temporally in a program of gene expression sufficient to facilitate the biochemical and morphological changes necessary for branching morphogenesis.
Editorial: Welcoming Contributions on Topical Themes in Information Systems Research (2014)

The plethora of topical research themes in the information systems (IS) field is often considered a challenge, as they make it difficult to establish an intellectual core for the discipline.Topical themes, however, also have the potential to develop the field in important ways.IS research investigates the design, use, and impact of information technology (IT), and topical themes focus on novel matters, such as those related to a domain, technology, or methodology in IS research.As such, research on topical themes is often both innovative and highly relevant.While investigating novel IT-related phenomena brings diversity to IS research, it also accelerates it and fosters the contributions our fields makes to society.Leaving the beaten track helps to align our research agendas with dynamically changing societal requirements and socio-technological opportunities.Even so, investigating topical themes has limitations and brings challenges, the most important of which is these themes' integration with extant knowledge.Researchers can use four principles-conceptualization, contribution, IT orientation, and contextualization-to position topical themes in IS research.
Soft start equipment with common current source inverter for several high voltage motors (1989)

Today, there is an evergrowing demand for frequency control and soft starting of three-phase induction motors with squirrel-cages. In addition to new installations, constant speed or hard starting (direct on line) drive systems, installed many years ago, can be adapted to the new operation requirements. In these cases, frequency control or soft start equipment is added to the motor. Mainly two different systems for soft starting can be applied: the three phase AC power controller; and the frequency converter. In the following, the design and application of control and power electronics for such special soft start equipment with frequency converter is described. >
Functional Heterologous Protein Expression by Genetically Engineered Probiotic Yeast Saccharomyces boulardii (2014)

Recent studies have suggested the potential of probiotic organisms to be adapted for the synthesis and delivery of oral therapeutics. The probiotic yeast Saccharomyces boulardii would be especially well suited for this purpose due to its ability, in contrast to probiotic prokaryotes, to perform eukaryotic post translational modifications. This probiotic yeast thus has the potential to express a broad array of therapeutic proteins. Currently, however, use of wild type (WT) S. boulardii relies on antibiotic resistance for the selection of transformed yeast. Here we report the creation of auxotrophic mutant strains of S. boulardii that can be selected without antibiotics and demonstrate that these yeast can express functional recombinant protein even when recovered from gastrointestinal immune tissues in mice. A UV mutagenesis approach was employed to generate three uracil auxotrophic S. boulardii mutants that show a low rate of reversion to wild type growth. These mutants can express recombinant protein and are resistant in vitro to low pH, bile acid salts, and anaerobic conditions. Critically, oral gavage experiments using C57BL/6 mice demonstrate that mutant S. boulardii survive and are taken up into gastrointestinal immune tissues on a similar level as WT S. boulardii. Mutant yeast recovered from gastrointestinal immune tissues furthermore retain expression of functional recombinant protein. These data show that auxotrophic mutant S. boulardii can safely express recombinant protein without antibiotic selection and can deliver recombinant protein to gastrointestinal immune tissues. These auxotrophic mutants of S. boulardii pave the way for future experiments to test the ability of S. boulardii to deliver therapeutics and mediate protection against gastrointestinal disorders.
Endogenous nitric oxide in the control of skeletal muscle oxygen extraction during exercise (2000)

Our previous studies uncovered an inhibitory effect of nitric oxide (NO) on leg skeletal muscle respiration in dogs at rest. The role of NO in the modulation of O2 consumption and O2 extraction in hindlimb muscle during elevated metabolic states was investigated in chronically instrumented dogs while walking and at three exercise intensities which markedly increased hindlimb blood flow. Walking resulted in increased O2 consumption by 17 +/- 4 mL min-1 and O2 extraction from 24 +/- 1 to 37 +/- 8%, with no alteration in hindlimb blood flow (BFLeg) and vascular resistance (VRLeg). Running at the highest speed (9.1 mph) resulted in an increase in BFLeg from 0.67 +/- 0.05 to 2.2 +/- 0.1 L min-1, a reduction of VRLeg and elevation of hindlimb O2 consumption from 33 +/- 3 to 226 +/- 21 mL min-1 and O2 extraction from 29 +/- 2 to 61 +/- 5%, with a decrease in leg venous PO2 from 38 +/- 1 to 25 +/- 1 mmHg. After nitro-L-arginine (NLA) (35 mg kg-1, i.v.) to inhibit endogenous NO synthesis, walking caused greater increases in hindlimb O2 consumption (29 +/- 5 mL min-1) and O2 extraction (43 +/- 1 to 60 +/- 3%) (both P < 0.05), with no significant change in BFLeg. During running at the highest speed, BFLeg was 1.9 +/- 0.1 L min-1 (P < 0. 05) and VRLeg was higher, accompanied by increases in hindlimb O2 consumption from 49 +/- 7 to 318 +/- 24 mL min-1 and O2 extraction from 41 +/- 2 to 79 +/- 4% (both P < 0.05), with a greater decrease in leg venous PO2 from 33 +/- 1 to 20 +/- 1 mmHg (P < 0.05). Similar results were found for intermediate levels of exercise. Our results indicate that NO modulates hindlimb skeletal muscle O2 extraction and O2 usage whether blood flow increased or not during exercise.
EEG Signal Processing (2007)

Electroencephalograms (EEGs) are becoming increasingly important measurements of brain activity and they have great potential for the diagnosis and treatment of mental and brain diseases and abnormalities. With appropriate interpretation methods they are emerging as a key methodology to satisfy the increasing global demand for more affordable and effective clinical and healthcare services. Developing and understanding advanced signal processing techniques for the analysis of EEG signals is crucial in the area of biomedical research. This book focuses on these techniques, providing expansive coverage of algorithms and tools from the field of digital signal processing. It discusses their applications to medical data, using graphs and topographic images to show simulation results that assess the efficacy of the methods. Additionally, expect to find: explanations of the significance of EEG signal analysis and processing (with examples) and a useful theoretical and mathematical background for the analysis and processing of EEG signals; an exploration of normal and abnormal EEGs, neurological symptoms and diagnostic information, and representations of the EEGs; reviews of theoretical approaches in EEG modelling, such as restoration, enhancement, segmentation, and the removal of different internal and external artefacts from the EEG and ERP (event-related potential) signals; coverage of major abnormalities such as seizure, and mental illnesses such as dementia, schizophrenia, and Alzheimer's disease, together with their mathematical interpretations from the EEG and ERP signals and sleep phenomenon; descriptions of nonlinear and adaptive digital signal processing techniques for abnormality detection, source localization and brain-computer interfacing using multi-channel EEG data with emphasis on non-invasive techniques, together with future topics for research in the area of EEG signal processing. © 2007 by John Wiley & Sons Ltd,. All Rights Reserved.
Intraperitoneal injection of tetracyclines protects mice from lethal endotoxemia downregulating inducible nitric oxide synthase in various organs and cytokine and nitrate secretion in blood (1997)

We have tested whether tetracyclines (TETs) are able to protect mice from lipopolysaccharide (LPS)-induced shock, a cytokine-mediated inflammatory reaction. Mice, injected with a single dose of tetracycline base (TETb; 1.5, 10 and 20 mg/kg of body weight) or doxycycline (DOXY; 1.5 mg/kg), were significantly protected from a lethal intraperitoneal injection of LPS (500 micrograms per mouse). TETs acted in early events triggered in response to LSP; in fact, they were no longer significantly protective if injected more than 1 h after the injection of endotoxin. LPS-treated mice protected by TETs showed a significant inhibition of tumor necrosis factor alpha (TNF-alpha), interleukin-1 alpha (IL-1 alpha), and nitrate secretion in the blood, events that were directly related with the survival. In mice treated with TETs a significant decrease of inducible nitric oxide synthase (iNOS) activity was observed in spleen and peritoneal cells compared with that detected in mice treated with LPS alone. Furthermore, TETs were found to inhibit NO synthesis by peritoneal macrophages stimulated in vitro with LPS. On the contrary, TETs were unable to decrease the ability of the macrophages to synthesize IL-1 alpha and TNF-alpha in vitro. These results indicate that TETs are not able to act directly on the synthesis of these cytokines, but they may modulate other pathways that could in turn be responsible for the inhibition of IL-1 alpha and TNF-alpha synthesis. Altogether, these results indicate that TETs are advantageous candidates for the prophylaxis and treatment of septic shock in mice, having both antimicrobial activity and the ability to inhibit endogenous TNF-alpha, IL-1 alpha, and iNOS, hence, exerting, potent anti-inflammatory effects.
A Stakeholder Approach to Strategic Performance Measurement (1997)

Traditional accounting-based performance measurement systems are unsuited to current organizations in which the relationships with employees, customers, suppliers, and other stakeholders have changed, say these authors. Established measures lack the focus to evaluate intangibles such as service, innovation, employee relations, and flexibility. A stakeholder approach to performance measurement captures strategic planning issues, while the choices a company makes in strategic planning direct the design of the performance measurement system. 

Atkinson et al. define two groups of stakeholders: environmental (customers, owners, and the community) and process (employees and suppliers). The company exists to serve the objectives of the stakeholders, which become its primary objectives. What the company expects from and gives to each stakeholder group to achieve its primary objectives are its secondary objectives. The company must plan for and negotiate explicit and implicit contracts with stakeholders and evaluate whether the plan meets the expectations of all stakeholders. 

Employees design, implement, and manage processes to achieve the secondary objectives, expecting the primary objectives to result. Therefore, according to the authors, the company's performance measurement system must evaluate all processes based on their contribution to achieving secondary objectives. In their view, the system, which is the heart of a company's control system, must: 

1. Help evaluate whether the company is getting expected contributions from employees and suppliers and returns from customers. 

2. Help evaluate whether the company is giving each stakeholder group what it needs to continue to contribute. 

3. Guide the design and implementation of processes that contribute to the secondary objectives. 

4. Help evaluate the company's planning and implicit and explicit contracts with its stakeholders. 

Performance measurement has a coordinating role, in which it directs attention to the company's primary and secondary objectives. It has a monitoring role, in which it measures and reports performance in meeting stakeholder requirements. And it has a diagnostic role, in which it promotes understanding of how process performance affects organizational learning and performance. 

The authors examine the performance measurement system at the Bank of Montreal, whose objective was to maximize long-term return on investment for shareowners. The bank wanted its system to: 

1. Focus decision makers on what drives success. 

2. Help management understand and communicate to people outside and inside the bank what contributes to primary financial objectives. 

3. Diagnose what drives current profitability. 

4. Form a basis for performance management. 

The authors' model is a vital system that includes both financial and nonfinancial measures of performance to help an organization's members understand and evaluate the factors for success.
Clinical diagnosis of immune inner‐ear disease (1988)

The purpose of this study was to develop a high-risk clinical profile of patients with autoimmune (immune-mediated) inner-ear disease. The records of 52 patients diagnosed over the past 5 years were reviewed. Age, sex, bilateral versus unilateral involvement, otologic symptoms, concomitant systemic immune disease, and presenting clinical diagnoses were recorded. The presenting diagnoses were Cogan's syndrome, Meniere's syndrome, Dandy's syndrome without hearing loss, or progressive sensorineural hearing loss without dizziness. Because Cogan's and Dandy's syndromes were relatively uncommon, the typical high-risk clinical profile was a middle-aged patient (often female) with bilateral, asymmetric, progressive sensorineural hearing loss, with or without dizziness, and occasional systemic immune disease such as rheumatoid arthritis. When a more common clinical diagnosis cannot be reached in suspicious patients, immune laboratory tests should be obtained and a trial of immunotherapy offered. Positive test results and beneficial response to therapy support a presumptive diagnosis of immune inner-ear disease.
Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation (2015)

Colony formation in soft agar is the gold-standard assay for cellular transformation in vitro, but it is unsuited for high-throughput screening. Here, we describe an assay for cellular transformation that involves growth in low attachment (GILA) conditions and is strongly correlated with the soft-agar assay. Using GILA, we describe high-throughput screens for drugs and genes that selectively inhibit or increase transformation, but not proliferation. Such molecules are unlikely to be found through conventional drug screening, and they include kinase inhibitors and drugs for noncancer diseases. In addition to known oncogenes, the genetic screen identifies genes that contribute to cellular transformation. Lastly, we demonstrate the ability of Food and Drug Administration-approved noncancer drugs to selectively kill ovarian cancer cells derived from patients with chemotherapy-resistant disease, suggesting this approach may provide useful information for personalized cancer treatment.