gebhart/patrepeval huggingface dataset:
Synthetic Lethal Genetic Interactions That Decrease Somatic Cell Proliferation in Caenorhabditis elegans Identify the Alternative RFC<sup>CTF18</sup>as a Candidate Cancer Drug Target (2009)

Somatic mutations causing chromosome instability (CIN) in tumors can be exploited for selective killing of cancer cells by knockdown of second-site genes causing synthetic lethality. We tested and statistically validated synthetic lethal (SL) interactions between mutations in six Saccharomyces cerevisiae CIN genes orthologous to genes mutated in colon tumors and five additional CIN genes. To identify which SL interactions are conserved in higher organisms and represent potential chemotherapeutic targets, we developed an assay system in Caenorhabditis elegans to test genetic interactions causing synthetic proliferation defects in somatic cells. We made use of postembryonic RNA interference and the vulval cell lineage of C. elegans as a readout for somatic cell proliferation defects. We identified SL interactions between members of the cohesin complex and CTF4, RAD27, and components of the alternative RFC(CTF18) complex. The genetic interactions tested are highly conserved between S. cerevisiae and C. elegans and suggest that the alternative RFC components DCC1, CTF8, and CTF18 are ideal therapeutic targets because of their mild phenotype when knocked down singly in C. elegans. Furthermore, the C. elegans assay system will contribute to our knowledge of genetic interactions in a multicellular animal and is a powerful approach to identify new cancer therapeutic targets.
3D Fragment Reassembly Using Integrated Template Guidance and Fracture-Region Matching (2015)

This paper studies matching of fragmented objects to recompose their original geometry. Solving this geometric reassembly problem has direct applications in archaeology and forensic investigation in the computer-aided restoration of damaged artifacts and evidence. We develop a new algorithm to effectively integrate both guidance from a template and from matching of adjacent pieces' fracture-regions. First, we compute partial matchings between fragments and a template, and pairwise matchings among fragments. Many potential matches are obtained and then selected/refined in a multi-piece matching stage to maximize global groupwise matching consistency. This pipeline is effective in composing fragmented thin-shell objects containing small pieces, whose pairwise matching is usually unreliable and ambiguous and hence their reassembly remains challenging to the existing algorithms.
Study on New Characteristic CeO<sub>2</sub>-ZrO<sub>2</sub> Based Material for Advanced TWC (2009)

<div class="htmlview paragraph">Performance improvements resulting from the adoption of a new type CeO<sub>2</sub>-ZrO<sub>2</sub>-based material were found using a two-brick three way catalyst (TWC) system. Compared to a conventional CeO<sub>2</sub>-ZrO<sub>2</sub>-based material, this new type CeO<sub>2</sub>-ZrO<sub>2</sub> has both a larger oxygen storage capacity and a slower oxygen release rate. Such characteristics were confirmed by fundamental studies. Vehicle evaluations showed this material was most effective for hot NO<sub>x</sub> control when used in the rear catalyst, especially after fuel cuts. The improvement in NOx was thought to be caused by the increased oxygen storage capacity (OSC), which effectively stored excess oxygen during fuel cuts. As a result, the air-to-fuel ratio (A/F) surrounding the active sites could be kept at stoichiometry even if the engine control shifted to a lean setting.</div>
Accelerated waveform methods for parallel transient simulation of semiconductor devices (1996)

Simulating transients in semiconductor devices involves numerically solving the time-dependent drift-diffusion equations, usually in two or three space dimensions. Because of the computation cost of these simulations, methods that perform careful domain decomposition so as to exploit parallel processing have received much recent attention. In this paper, we describe using accelerated waveform relaxation (WR) to perform parallel device transient simulation using both clusters of workstations and the IBM SP-2. The accelerated WR algorithms are compared to pointwise direct and iterative methods, and it is shown that the accelerated WR method is competitive on a single processor. In addition, it is shown that with a domain decomposition chosen for rapid iterative method convergence rather than parallel efficiency, the pointwise methods parallelize poorly but the WR method achieves near linear speedup (with respect to the number of processors) on the IBM SP-2.
Familial amyotrophic lateral sclerosis (2002)

The increasing complexity of the pathways implicated in the pathogenesis of familial amyotrophic lateral sclerosis (ALS) has stimulated intensive research in many directions. Genetic analysis of familial ALS has yielded six loci and one disease gene (SOD1), initially suggesting a role for free radicals in the disease process, although the mechanisms through which the mutant exerts toxicity and results in selective motor neuron death remain uncertain. Numerous studies have focused on structural elements of the affected cell, emphasizing the role of neurofilaments and peripherin and their functional disruption in disease. Other topics examined include cellular homeostasis of copper and calcium, particularly in the context of oxidative stress and the processes of protein aggregation, glutamate excitotoxicity, and apoptosis. It has become evident that there is considerable interplay between these mechanisms and, as the role of each is established, a common picture may emerge, enabling the development of more targeted therapies. This study discusses the main areas of investigation and reviews the findings.
Computed tomography evaluation of the morphometry and variations of the infraorbital canal relating to endoscopic surgery (2017)

Precise knowledge of the infraorbital canal corpus types and relationship with the morphometry allow surgeons to choose an appropriate surgical approach to avoid iatrogenic infraorbital nerve injury.
High gain erbium doped fiber amplifier and tunable erbium doped fiber laser pumped at 532 nm (1990)

Erbium doped fiber amplifiers (EDFAs) have been used in various lightwave system experiments including high speed, long distance transmission experiments,1 and a multichannel AM-VSB television signal transmission experiment using an EDFA as an optical power amplifier.2
On‐line LC‐GC‐AED and LC‐GC‐MS – multidimensional methods for the analysis of PAC in fuels, combustion emissions and atmospheric samples (1997)

Abstract The composition and concentration of polycyclic aromatic compounds (PAC) in fuels. Theier combustion products and in the atmosphere remains a topic of considerable interest. Despite the wealth of literature on the identification of PAC, speciation at low concentrations remains difficult due to instrument limitation and the complexity of fuel and environmental samples. Consequently on line sample preparation procedures (SPE, SFE, LC, etc .) are becomeing an increasingly important step in the analysis procedure particularly where sample clean‐up and fractionation are essential for improving analytical resolution. In this study a normal phase high pressure analytical resolution. In this study a normal phase high pressure liquid chromatography‐gas chromatography (LC‐GC) system has been developed to provide quantitative analysis of samples, as diverse as coal liquids, petroleum fuels, diesel exhaust particulates, and urban air particulates. Separation and identification of parent and alkylated PAH, hetercycline nitro‐and oxy‐PAC can be achieved by direct coupling to an atomic emission detector and a bech top mass spectrometer. For both systems the primary LC separation combined with the large sample volume transferred to GC vastly improves detection limits. Furthermore the complimentary nature of the two detectors used enables the positive indentification of many unknowns.
The Fabrication and Characterization of Superconducting Tl<sub>0.5</sub>Pb<sub>0.5</sub>(Ca<sub>1-x</sub>M<sub>x</sub>)Sr<sub>2</sub>Cu<sub>2</sub>O<sub>y</sub> Compounds with M=Mischmetal (1989)

Bulk superconductivity with T c (zero) up to 101 K in Tl 0.5 Pb 0.5 (Ca 1- x M x )Sr 2 Cu 2 O y system with M=mischmetal and x =0, 0.05, 0.1, 0.2, and 0.3 was observed. The powder X-ray diffraction profiles indicate a single phase, P4/mmm tetragonal crystal structure with a =3.80±0.02 Å and c =12.05±0.02 Å for Tl 0.5 Pb 0.5 (Ca 1- x M x )Sr 2 Cu 2 O y compounds. T c (zero)'s were found to be 78, 91, 101, 98, and 87 K for x =0, 0.05, 0.1, 0.2 and 0.3 respectively. The sample of Tl 0.5 Pb 0.5 (Ca 0.9 M 0.1 )Sr 2 Cu 2 O y was found to be the most homogeneous both in composition and structure. Meissner signal of this sample indicates the T c onset around 100 K and mass diamagnetic susceptibility - χ g at 10 K is 1.3×10 -3 emu/g·G (field-cooled at 100 G).
Proper motion and orbital study of galactic globular cluster M79 (2005)

Absolute proper motion determination is made for Galactic globular cluster M79 using photographic plates of Shanghai Observatory, with a time interval of 29 years. Adopting the distance and radial velocity data of this cluster from Harris (1999) and the Galactic gravitational potential model of AllenSantillan (1991), it is calculated for M79 its present spatial velocity and orbital parameters as well. Further discussion is made on the uncertainties related to the study of the globular cluster kinematics with proper motion data.
Expression of TRPC3 in Chinese Hamster Ovary Cells Results in Calcium-activated Cation Currents Not Related to Store Depletion (1997)

TRPC3 (or Htrp3) is a human member of the trp family of Ca2+-permeable cation channels. Since expression of TRPC3 cDNA results in markedly enhanced Ca2+ influx in response to stimulation of membrane receptors linked to phospholipase C (Zhu, X., J. Meisheng, M. Peyton, G. Bouley, R. Hurst, E. Stefani, and L. Birnbaumer. 1996. Cell. 85:661-671), we tested whether TRPC3 might represent a Ca2+ entry pathway activated as a consequence of depletion of intracellular calcium stores. CHO cells expressing TRPC3 after intranuclear injection of cDNA coding for TRPC3 were identified by fluorescence from green fluorescent protein. Expression of TRPC3 produced cation currents with little selectivity for Ca2+ over Na+. These currents were constitutively active, not enhanced by depletion of calcium stores with inositol-1,4,5-trisphosphate or thapsigargin, and attenuated by strong intracellular Ca2+ buffering. Ionomycin led to profound increases of currents, but this effect was strictly dependent on the presence of extracellular Ca2+. Likewise, infusion of Ca2+ into cell through the patch pipette increased TRPC3 currents. Therefore, TRPC3 is stimulated by a Ca2+-dependent mechanism. Studies on TRPC3 in inside-out patches showed cation-selective channels with 60-pS conductance and short (<2 ms) mean open times. Application of ionomycin to cells increased channel activity in cell-attached patches. Increasing the Ca2+ concentration on the cytosolic side of inside-out patches (from 0 to 1 and 30 microM), however, failed to stimulate channel activity, even in the presence of calmodulin (0.2 microM). We conclude that TRPC3 codes for a Ca2+-permeable channel that supports Ca2+-induced Ca2+-entry but should not be considered store operated.
Design and Synthesis of Novel Thiazole-Containing Cross-Linked Polyamides Related to the Antiviral Antibiotic Distamycin (2000)

A family of naturally occurring oligopeptides includes netropsin, distamycin, anthelvencin, kikumycin B, amidinomycin, and norformycin. Netropsin (I) and distamycin (II) express their biological activities by targeting specific sequences of chemical functionalities in the minor groove of DNA. Both netropsin and distamycin can be regarded as polyamide chains in which each alpha-carbon has been replaced by a five-membered pyrrole ring. The repeat distance in such an augmented polyamide chain is almost the same as the distance from one base pair to the next along the floor of a minor groove within beta-DNA. In this paper we report the synthesis of 16-21 cross-linked polyamides containing a thiazole heterocyclic ring bearing the active functionalites NH(2), NHCHO, or H. 16 and 17 were synthesized by DCC and HOBt catalyzed reaction of 5 with 14 and 15, while the formylation products 18 and 19 were obtained by coupling the formylated 4-methyl-thiazolated acid 6 with 14 and 15. The deaminated compounds 20 and 21 were obtained by the coupling of 5-trichloroacetyl-4-methylthiazole 7 synthesized from 4-methylthiazole. All the six cross-linked polyamides 16-21 were tested for their DNA gyrase inhibition. The studies have shown these polyamides have better sequence recognition and a greater percentage of inhibition than the corresponding monomers. The compound 17 shows complete inhibition of gyrase at 0.5 microM concentration as compared to the naturally occurring distamycin at 1.0 microM.
Selecting the right flowmeter. Part 2. Comparing candidates (1977)

Guidelines recommended by Great Britian's Kent Instruments Ltd. help the engineer in determing the most suitable flowmeter for his purposes. A flowchart and table describing fluid characteristics and operating conditions aid in establishing a preliminary list of possible meters. By precisely identifying measurement requirements in terms of accuracy, cost, reliability, installation, maintenance, and display, the selecting engineer can then identify the device that most closely fits his needs.
PREPARATION AND RESOLUTION OF THE <i>fac</i>-TRIS(2-AMINOETHYLDIMETHYLPHOSPHINE)COBALT(III) COMPLEX AND THE ABSOLUTE CONFIGURATION OF ITS (+)589-ISOMER DETERMINED BY X-RAY ANALYSIS (1980)

Abstract A new lemon-yellow fac-[Co{NH2CH2CH2P(CH3)2}3]Br3·3H2O complex was prepared and resolved into enantiomers by SP-Sephadex column chromatography. The absolute configuration of the (+)589-isomer was determined by the X-ray method to be Δ-configuration.
Effect of In Utero and Early-Life Conditions on Adult Health and Disease (2008)

Many lines of evidence, including epidemiologic data and extensive clinical and experimental studies, indicate that early life events play a powerful role in influencing later susceptibility to certain chronic diseases. This review synthesizes evidence from several disciplines to support the contention that environmental factors acting during development should be accorded greater weight in models of disease causation.
Self‐Assembled Metal‐Organic Frameworks Crystals for Chemical Vapor Sensing (2014)

A 3D metal-organic frameworks (MOFs) crystals film is obtained via Langmuir-Blodgett technique and used as a photonic sensor for chemical vapor detection. The MOFs crystals film exhibits both acute responses towards various chemical vapors and high controllability in terms of peak intensity and position. The method represents a general, facile and flexible strategy for the fabrication of MOFs-based photonic sensors.
A parallel memory architecture for video coding (2008)

To efficiently exploit the performance of single instruction multiple data (SIMD) architectures for video coding, a parallel memory architecture with power-of-two memory modules is proposed. It employs two novel skewing schemes to provide conflict-free access to adjacent elements (8-bit and 16-bit data types) or with power-of-two intervals in both horizontal and vertical directions, which were not possible in previous parallel memory architectures. Area consumptions and delay estimations are given respectively with 4, 8 and 16 memory modules. Under a 0.18-μm CMOS technology, the synthesis results show that the proposed system can achieve 230 MHz clock frequency with 16 memory modules at the cost of 19k gates when read and write latencies are 3 and 2 clock cycles, respectively. We implement the proposed parallel memory architecture on a video signal processor (VSP). The results show that VSP enhanced with the proposed architecture achieves 1.28× speedups for H.264 real-time decoding.
Global Regulation of Food Supply by <i>P</i> <i>seudomonas p</i> <i>utida</i> DOT-T1E (2010)

Pseudomonas putida DOT-T1E was used as a model to develop a "phenomics" platform to investigate the ability of P. putida to grow using different carbon, nitrogen, and sulfur sources and in the presence of stress molecules. Results for growth of wild-type DOT-T1E on 90 different carbon sources revealed the existence of a number of previously uncharted catabolic pathways for compounds such as salicylate, quinate, phenylethanol, gallate, and hexanoate, among others. Subsequent screening on the subset of compounds on which wild-type DOT-TIE could grow with four knockout strains in the global regulatory genes Deltacrc, Deltacrp, DeltacyoB, and DeltaptsN allowed analysis of the global response to nutrient supply and stress. The data revealed that most global regulator mutants could grow in a wide variety of substrates, indicating that metabolic fluxes are physiologically balanced. It was found that the Crc mutant did not differ much from the wild-type regarding the use of carbon sources. However, certain pathways are under the preferential control of one global regulator, i.e., metabolism of succinate and d-fructose is influenced by CyoB, and l-arginine is influenced by PtsN. Other pathways can be influenced by more than one global regulator; i.e., l-valine catabolism can be influenced by CyoB and Crp (cyclic AMP receptor protein) while phenylethylamine is affected by Crp, CyoB, and PtsN. These results emphasize the cross talk required in order to ensure proper growth and survival. With respect to N sources, DOT-T1E can use a wide variety of inorganic and organic nitrogen sources. As with the carbon sources, more than one global regulator affected growth with some nitrogen sources; for instance, growth with nucleotides, dipeptides, d-amino acids, and ethanolamine is influenced by Crp, CyoB, and PtsN. A surprising finding was that the Crp mutant was unable to flourish on ammonium. Results for assayed sulfur sources revealed that CyoB controls multiple points in methionine/cysteine catabolism while PtsN and Crc are needed for N-acetyl-l-cysteamine utilization. Growth of global regulator mutants was also influenced by stressors of different types (antibiotics, oxidative agents, and metals). Overall and in combination with results for growth in the presence of various stressors, these phenomics assays provide multifaceted insights into the complex decision-making process involved in nutrient supply, optimization, and survival.
2A1-B01 The Analysis of Skillful Hydraulic Excavator Operation (2006)

In recent years, some unmanned operation systems for hydraulic excavator are required and some systems are already developed. However, it is difficult to realize effective operation utilizing such systems. In this paper, we described to examine to extract operator's skill for controlling unmanned hydraulic excavator. We compare operation of skillful operator with non-skillful operator and discuss about the result for modeling of operator's skill. Prom these results, we have revealed that skillful operator realized unified trajectories with quick moving and this causes the efficient performance.
Location-aware long-lived route selection in wireless ad hoc network (2002)

Many routing protocols suitable for wireless ad hoc network have been proposed. However most of them have focused on the reachability among nodes which want to communicate with each other. Actually, even if a route has been successfully acquired to be established, due to the node's mobility, there will be frequent route reconstructions, resulting in the need for a new partial or full route to the destination. Therefore, the selection of a long-lived route among multiple possible routes at the destination (if the source initiated on-demand routing protocol is applied to a wireless ad hoc network) helps to reduce the number of route disconnections. In this paper, for deriving a long-lived route, we exploit location information obtained by the GPS (Global Positioning System) and information of each node's radio transmission range. Additionally, in order to avoid excessive beacon signals used by the ABR (associativity-based routing) protocol, only nodes on the acquired route exchange their beacon signals when detecting a route failure. Through simulation, we show that our proposed scheme is applicable to wireless ad hoc network.
Control of Electronic Structure of Graphene by Various Dopants and Their Effects on a Nanogenerator (2011)

Abstract not Available.
Fast base extension using a redundant modulus in RNS (1989)

A technique to extend the base of a residue number system (RNS) based on the Chinese remainder theorem (CRT) and the use of a redundant modulus, is proposed. The technique obtains the residue(s) of a given number in the extended moduli without resorting to the traditional mixed-radix conversion (MRC) algorithm. The base extension can be achieved in log/sub 2/n table lookup cycles, where n is the number of moduli in the RNS. The superiority of the technique, compared in terms of latency and hardware requirements to the traditional Szabo-Tanaka method is demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Î³-secretase complex: from structure to function (2014)

One of the most critical pathological features of Alzheimer's disease (AD) is the accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain. Aβ is derived from β-amyloid precursor protein (APP) through sequential cleavage by β- and γ-secretases. γ-secretase is a high molecular weight complex minimally composed of four components: presenilins (PS), nicastrin, anterior pharynx defective 1 (APH-1), and presenilin enhancer 2 (PEN-2). In addition to APP, γ-secretase also cleaves many other type I transmembrane (TM) protein substrates. As a crucial enzyme for Aβ production, γ-secretase is an appealing therapeutic target for AD. Here, we summarize current knowledge on the structure and function of γ-secretase, as well as recent progress in developing γ-secretase targeting drugs for AD treatment.
A strategy for real-time kernel support in application-specific HW/SW embedded architectures (1996)

Heterogeneous embedded multiprocessor architectures are becoming more prominent as a key design solution to today's microelectronics design problems. These application-specific architectures integrate multiple software programmable processors and dedicated hardwarecomponents together on to a single cost-efficient IC. In contrast to general-purpose computer systems, embedded systems are designed and optimized to provide specific functionality, using possibly a combination of different classes of processors (e.g. DSPs, microcontrollers) from different vendors. While these customized heterogeneous multiprocessor architectures offer designers new possibilities to tradeoff programmability, processing performance, power dissipation, and design turnaround time, there is currently a lack of tools to support the programming of these architectures. In this paper, we consider the problem of providing real-time kernel support for managing the concurrent software tasks that are distributed over a set of processorsin an application-specific multiprocessorarchitecture. This is complementary to current research activities that aim to provide efficient retargetable code generation
Notes on Colias christina Edw., and C. astraea Edw. (1884)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.