gebhart/patrepeval huggingface dataset:
Contributions to a proposed standard for binary floating-point arithmetic (computer arithmetic) (1984)

RG confers protection against neuronal apoptosis by reducing ROS levels and suppressing mitochondrial dysfunction and NF-κB activation, which results in suppression of NF-κB-mediated activation of Nucling expression in Aβ-treated cells. Supplementation with RG may be beneficial for preventing Aβ-induced neuronal cell death associated with AD.
Seeking huntington disease biomarkers by multimodal, cross‐sectional basal ganglia imaging (2012)

Neurodegeneration of the striatum in Huntington disease (HD) is characterized by loss of medium-spiny neurons, huntingtin nuclear inclusions, reactive gliosis, and iron accumulation. Neuroimaging allows in vivo detection of the macro- and micro-structural changes that occur from presymptomatic stages of the disease (preHD). The aim of our study was to evaluate the reliability of multimodal imaging as an in vivo biomarker of vulnerability and development of the disease and to characterize macro- and micro-structural changes in subcortical nuclei in HD. Macrostructure (T1-weighted images), microstructure (diffusion tensor imaging), and iron content (R 2* relaxometry) of subcortical nuclei and medial temporal lobe structures were evaluated by a 3 T scanner in 17 preHD carriers, 12 early-stage patients and 29 matched controls. We observed a volume reduction and microstructural changes in the basal ganglia (caudate, putamen, and globus pallidus) and iron accumulation in the globus pallidus in both preHD and symptomatic subjects; all these features were significantly more pronounced in patients, in whom degeneration extended to the other subcortical nuclei (i.e., thalamus and accumbens). Mean diffusivity (MD) was the most powerful predictor in models explaining more than 50% of the variability in HD development in the caudate, putamen, and thalamus. These findings suggest that the measurement of MD may further enhance the well-known predictive value of striatal volume to assess disease progression as it is highly sensitive to tissue microimpairment. Multimodal imaging may detect brain changes even in preHD stages.
Characterization of Coal Macerals by Fluorescence Microscopy (1984)

The use of fluorescence microscopy to characterize coal macerals is a successful recent innovation. Compared to conventional white-light analysis, fluorescence microscopy reveals a greater number and variety of macerals, as well as, characteristic textures and structures. Although the spectra of fluorescent macerals are broad-peaked and, at this time, not suitable for chemical structure analysis, they are characteristic of maceral types and rank. Spectral analysis of the liptinite macerals in single coals of the Illinois Basin shows that the macerals can be grouped or discriminated both petrographically and statistically using various spectral parameters, specifically the wavelength of maximum intensity (λ max) and the red/green quotient (Q = intensity 650nm/500nm). In a number of cases the spectral data reveal the presence of more than one variety of a given maceral type in some samples. Maceral groupings on the basis of increasing λ max and Q consistently show the same order: fluorinite, resinite, sporinite, cutinite. For example, in the Brazil Block Seam (Indiana) the following maceral groups can be distinguished: fluorinite (λ max = 520 nm, Q = 0.58), sporinite type I (λ max =550 nm, Q = 0.85), sporinite type II (λ max = 590 nm, Q = 1.00), cutinite (λ max = 610 nm, Q = 1.47). In addition, altered (weathered) forms of sporinite (λ max = 690 nm, Q = 1.22) and cutinite (λ max = 650 nm, Q = 2.27) were also observed. Studies on other coal samples of different ranks indicate that the fluorescence properties are very sensitive to changes in rank.
LOC, LOS AND LOES AT-SPEED TESTING METHODOLOGIES FOR AUTOMATIC TEST PATTERN GENERATION USING TRANSITION DELAY FAULT MODEL (2014)

Faults, caused by timing-related defects in very large scale integrated circuits, are important to detect to optimize coverage and test time. Delay faults are only due to timing malfunction. At-speed test is only method to detect these delay faults. This paper describes and compares different at-speed testing techniques on vivid point of views along with them practical implementation. This paper also shows results generated by automatic test pattern generation tool for these techniques. Next, generated test patterns are simulated by using simulator and correctness of these methods are verified.
Direct Quantification of Gene Expression in Homogenates of Formalin-Fixed, Paraffin-Embedded Tissues (2006)

Formalin-fixed, paraffin-embedded (FFPE) tissues represent an important source of archival materials for gene expression profiling. We report here the development of a modified branch DNA assay that allows direct quantification of messenger RNA (mRNA) transcripts in homogenates from FFPE tissue sections without the need for RNA isolation and reverse transcription into cDNA. Formalin fixation essentially has no effect on the branch DNA assay, and RNA degradation only marginally reduces the signal by 2- to 3-fold. Under the same conditions, formalin fixation and RNA degradation greatly reduces real-time reverse transcription PCR (RT-PCR) efficiency, reducing signals by as much as 15- and 1400-fold, respectively. Although both technologies can generate biologically meaningful expression profiles from FFPE human lung tumor specimens, the branch DNA assay is more sensitive than real-time RT-PCR under the conditions tested. Our results therefore suggest that the branch DNA assay is an ideal tool for retrospective analysis of gene expression in archival tissues.
Novel rapid-thermal-processing for CIS thin-film solar cells (2002)

Device quality CuInSe/sub 2/ thin films have been synthesized by rapid-thermal-processing (RTP) of elemental Cu-In-Se stacked layers. The authors demonstrate for the first time solar cells with an efficiency above 10% produced at short heating cycles and without using toxic gases. The microstructure of these films is analysed in detail by SEM, TEM and SIMS. Morphology, crystal quality and solar cell efficiency are influenced drastically by the Cu/In atomic ratio. The predominant CIS crystal defects observed in indium-rich films are twins whereas in copper-rich films dislocations, stacking faults and precipitates are also observed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The effect of microalloying with silicon and germanium on microstructure and hardness of a commercial aluminum alloy (2003)

The effect of small additions of Si and Ge on the microstructure and hardness was investigated during aging of a commercial 2219 aluminum alloy. It was found that for the same level of microalloying in alloy 2219SG (containing Si and Ge), a maximum hardness was achieved 3 times faster than in alloy 2219S (without Ge). The accelerated precipitation kinetics is a consequence of the presence of fine Si?Ge particles, serving as heterogeneous precipitation sites for ?" strengthening particles.
Thiopentone Pretreatment for Propofol Injection Pain in Ambulatory Patients (1997)

Division of Ambulatory Anaesthesia, Department of Anaesthesia, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, British Columbia, Canada
Geomechanical Modeling of Reservoir Compaction, Surface Subsidence, and Casing Damage at the Belridge Diatomite Field (2000)

Summary Geologic, and historical well failure, production, and injection data were analyzed to guide development of three-dimensional geomechanical models of the Belridge diatomite field, California. The central premise of the numerical simulations is that spatial gradients in pore pressure induced by production and injection in a low permeability reservoir may perturb the local stresses and cause subsurface deformation sufficient to result in well failure. Time-dependent reservoir pressure fields that were calculated from three-dimensional black oil reservoir simulations were coupled unidirectionally to three-dimensional nonlinear finite element geomechanical simulations. The reservoir models included nearly 100,000 gridblocks (100 to 200 wells), and covered nearly 20 years of production and injection. The geomechanical models were meshed from structure maps and contained more than 300,000 nodal points. Shear strain localization along weak bedding planes that causes casing doglegs in the field was accommodated in the model by contact surfaces located immediately above the reservoir and at two locations in the overburden. The geomechanical simulations are validated by comparison of the predicted surface subsidence with field measurements, and by comparison of predicted deformation with observed casing damage. Additionally, simulations performed for two independently developed areas at South Belridge, Secs. 33 and 29, corroborate their different well failure histories. The simulations suggest the three types of casing damage observed, and show that, although water injection has mitigated surface subsidence, it can, under some circumstances, increase the lateral gradients in effective stress that in turn can accelerate subsurface horizontal motions. Geomechanical simulation is an important reservoir management tool that can be used to identify optimal operating policies to mitigate casing damage for existing field developments, and applied to incorporate the effect of well failure potential in economic analyses of alternative infilling and development options.
Comparative development of the turkey and chicken embryo from cleavage through hypoblast formation (1997)

The development of the turkey and chicken embryo from the first cleavage division through hypoblast formation is described. The early development of the chicken embryo has been categorized into 14 stages. A similar staging sequence for the turkey was not proposed until 1993, when we described the early development of the turkey embryo, which was divided into 11 stages. Comparatively, differences in the temporal and spatial development of the turkey and chicken blastoderm were evident. Of significance is the observation that at oviposition the turkey is in Stage VII and characterized by the first signs of area pellucida formation. In contrast, the chicken embryo at oviposition is in Stage X and area pellucida formation is completed. Similarly, the hypoblast, which is already apparent in the Stage X chicken embryo, does not appear in the turkey embryo until the egg is incubated. Furthermore, the anterior-posterior (head-tail) axis in the early embryo is achieved prior to oviposition in the chicken but after the onset of incubation in the turkey. It is apparent that the turkey embryo is less mature than the chicken embryo at oviposition. Whether this distinction is related to differences between the hatchability of turkey and chicken eggs is not yet known.
Manual and automatic seismic facies analysis on SISMAGE Tm Workstation. An example of image analysis technques applied to the exploration of Perdana‐Nakhoda turbiditic fan complex (Pliocene offshore Brunei) (1996)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1996Manual and automatic seismic facies analysis on SISMAGE Tm Workstation. An example of image analysis technques applied to the exploration of Perdana‐Nakhoda turbiditic fan complex (Pliocene offshore Brunei)Authors: Michel MoriceNaamen KeskesFrederic JeanjeanMichel MoriceIMA3G research project. Elf aquitaine production, CSTJF Avenue Larribau, 64018 PAU Cedex FRANCE, Naamen KeskesIMA3G research project. Elf aquitaine production, CSTJF Avenue Larribau, 64018 PAU Cedex FRANCE, and Frederic JeanjeanIMA3G research project. Elf aquitaine production, CSTJF Avenue Larribau, 64018 PAU Cedex FRANCEhttps://doi.org/10.1190/1.1826631 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1826631FiguresReferencesRelatedDetailsCited byPredicting geometry and stacking pattern of thin beds by interpreting geomorphology and waveforms using sequential stratal-slices in the Wheeler domainHongliu Zeng22 May 2015 | Interpretation, Vol. 3, No. 3Recent progress in analysis of seismically thin bedsHongliu Zeng and Kurt J. Marfurt11 March 2015 | Interpretation, Vol. 3, No. 3 SEG Technical Program Expanded Abstracts 1996ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1996 Pages: 2106 publication data© 1996 Copyright © 1996 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Michel Morice, Naamen Keskes, and Frederic Jeanjean, (1996), "Manual and automatic seismic facies analysis on SISMAGE Tm Workstation. An example of image analysis technques applied to the exploration of Perdana‐Nakhoda turbiditic fan complex (Pliocene offshore Brunei)," SEG Technical Program Expanded Abstracts : 320-323. https://doi.org/10.1190/1.1826631 Plain-Language Summary PDF DownloadLoading ...
IFN-β Down-Regulates the Expression of DNA Repair Gene <i>MGMT</i> and Sensitizes Resistant Glioma Cells to Temozolomide (2005)

Abstract Alkylating agents, such as temozolomide, are among the most effective cytotoxic agents used for malignant gliomas, but responses remain very poor. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. IFN-β can act as a drug sensitizer, enhancing toxicity against a variety of neoplasias, and is widely used in combination with other antitumor agents such as nitrosoureas. Here, we show that IFN-β sensitizes glioma cells that harbor the unmethylated MGMT promoter and are resistant to temozolomide. By means of oligonucleotide microarray and RNA interference, we reveal that the sensitizing effect of IFN-β was possibly due to attenuation of MGMT expression via induction of the protein p53. Our study suggests that clinical efficacy of temozolomide might be improved by combination with IFN-β using appropriate doses and schedules of administration.
A novel spiral radiofrequency coil for high field mouse cardiac imaging (2010)

The idea of a novel MR surface coil based on multi-turn spiral geometry is presented for use in mouse cardiac MRI. The benefits from flat, cylindrical arrangement of the coil are compared using computer simulations and MRI experiments in various cases of free space, phantom and animal loading conditions. Results show that the cylindrical case compares well with a commercially available birdcage coil offering a 50% signal intensity improvement for depths of penetration up to 6.1 mm from coil surface. There is also adequate B(1) field penetration that allows visualization of the lateral and inferior walls of the murine heart.
Role of Tricoordinate Al Sites in CH<sub>3</sub>ReO<sub>3</sub>/Al<sub>2</sub>O<sub>3</sub> Olefin Metathesis Catalysts (2016)

Re2O7 supported on γ-alumina is an alkene metathesis catalyst active at room temperature, compatible with functional groups, but the exact structures of the active sites are unknown. Using CH3ReO3/Al2O3 as a model for Re2O7/Al2O3, we show through a combination of reactivity studies, in situ solid-state NMR, and an extensive series of DFT calculations, that μ-methylene structures (Al-CH2-ReO3-Al) containing a Re═O bound to a tricoordinated Al (AlIII) and CH2 bound to a four-coordinated Al (AlIVb) are the precursors of the most active sites for olefin metathesis. The resting state of CH3ReO3/Al2O3 is a distribution of μ-methylene species formed by the activation of the C-H bond of CH3ReO3 on different surface Al-O sites. In situ reaction with ethylene results in the formation of Re metallacycle intermediates, which were studied in detail through a combination of solid-state NMR experiments, using labeled ethylene, and DFT calculations. In particular, we were able to distinguish between metallacycles in TBP (trigonal-bipyramidal) and SP (square-pyramidal) geometry, the latter being inactive and detrimental to catalytic activity. The SP sites are more likely to be formed on other Al sites (AlIVa/AlIVa). Experimentally, the activity of CH3ReO3/Al2O3 depends on the activation temperature of alumina; catalysts activated at or above 500 °C contain more active sites than those activated at 300 °C. We show that the dependence of catalytic activity on the Al2O3 activation temperature is related to the quantity of available AlIII-defect sites and adsorbed H2O.
Touch Of Ivory (1980)

i walk along the north pier just as i had so many summers before skipping over cement cracks and watching iron holes spout jets of liquid like an oily blue whale... TOUCH OF IVORY by Mary Cross English Junior i walk along the north pier just as i had so many summers before skipping over cement cracks and watching iron holes spout jets of liquid like an oily blue whale the wind whistles and hisses a familiar coo like those bonfire nights and my first kiss from the boy who wanted more smothering me with tiny gold flames gently passing in the soon-to-be night the sun all balled in orange i remember my whisking hair its sallow tints while i stand at the edge of the graffiti-written lighthouse and unchained memories to look into a small mirror only to see a subtle touch of ivory waved in the strands i thought never to change
Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: Mechanism and implication (2007)

More than 400 million people are susceptible to oxidative stress due to glucose-6-phosphate dehydrogenase (G6PD) deficiency. Protein glutathionylation is believed to be responsible for loss of protein function and/or cellular signaling during oxidative stress. To elucidate the implications of G6PD deficiency specifically in cellular control of protein glutathionylation, we used hydroxyethyldisulfide (HEDS), an oxidant which undergoes disulfide exchange with existing thiols. G6PD deficient (E89) cells treated with HEDS showed a significant increase in protein glutathionylation compared to wild-type (K1) cells. In order to determine whether increase in global protein glutathionylation by HEDS leads to loss of function of an important protein, we compared the effect of HEDS on global protein glutathionylation with that of Ku protein function, a multifunctional DNA repair protein, using a novel ELISA. E89 cells treated with HEDS showed a significant loss of Ku protein binding to DNA. Cellular protein thiol and GSH, whose disulfide is involved in protein glutathionylation, were decreased by HEDS in E89 cells with no significant effect in K1 cells. E89 cells showed lower detoxification of HEDS, that is, conversion of disulfide HEDS to free sulfhydryl mercaptoethanol (ME), compared to K1 cells. K1 cells maintained their NADH level in the presence of HEDS but that of E89 cells decreased by tenfold following a similar exposure. NADPH, a cofactor required to maintain reduced form of the thiols, was decreased more in E89 than K1 cells. The specific role of G6PD in the control of such global protein glutathionylation and Ku function was further demonstrated by reintroducing the G6PD gene into E89 (A1A) cells, which showed a normal phenotype.
Policy and Planning in the Drug Abuse Field (1979)

my discussion of the problems of women and prescription drug abuse. We need to view the difficulties experienced by individual women in a broader social and political perspective which will allow us to examine the reasons why this condition exists. What is needed at this point is a framework in which to examine these issues, move towards a clear definition of the problem(s), and work creatively to find solutions. I think this framework can be developed by looking at current public policy relating to drug abuse, and health care generally, and then proposing alternatives to current policies. First, it must be recognized that this problem of prescription drug abuse is directly related to the status of women in our society. As long as women are viewed and treated as second-class citizens, we will be prime targets for many disabling emotional and physical problems, including the abuse of drugs prescribed for us by, primarily, male caretakers. Policy and programming at all levels reflect this sexist bias of our society, in everything from lack of awareness of the problem, to unavailability of appropriate treatment services for women. Even the fact that female prescription drug users are referred to as hidden abusers reflects to some degree the hypocritical attitude of our culture toward women. We are expected to be models of propriety and uphold the moral fiber of the culture; yet without the personal, social, and economic supports that are more easily available to men, the pressures are ov6rwhelming. But we dare not admit it, for that would be reinforcing society's view of us as weak/passive/dependent, something we feel we must prove that we are not. The problems experienced by black, brown, and Asian women; poor women, gay women, and disabled women in dealing with stereotypes and biases of the majority culture are an overwhelming barrier to full participation in this society, rendering them perhaps even more vulnerable to developing a substance abuse problem. In terms of policy in the drug abuse field, there are a number of issues that we need to critically examine. The first is the tendency of current policy and programming to focus only on symptoms-the highly visible signs of drug use/abuse by individuals. The physical dependence on tranquilizers, the shakes, and irritability from diet pills: these are not the full scope of the problem. To see it as such leads to a view of the individual woman as weak and diseased; it promotes the development of treatment methods that are unrealistic and inappropriate; and it focuses attention on only a piece of the person, rather than the whole person. This symptomatic approach has historically characterized the drug abuse field and has contributed to the inordinate amount of attention and resources given to the her-
Expressivist Jurisprudence and the Depletion of Meaning (2001)

Bob Rodes, and participants in a workshop at the University of Minnesota all gave helpful comments in advance of the Sympo-
Advances in Development of a Genetic System for <i>Thermoanaerobacterium</i> spp.: Expression of Genes Encoding Hydrolytic Enzymes, Development of a Second Shuttle Vector, and Integration of Genes into the Chromosome (2000)

Despite recent success in transforming various thermophilic gram-type-positive anaerobes with plasmid DNA, use of shuttle vectors for the expression of genes other than antibiotic resistance markers has not previously been described. We constructed new vectors in order to express heterologous hydrolytic enzymes in our model system, Thermoanaerobacterium saccharolyticum JW/SL-YS485. Transformed Thermoanaerobacterium expressed active enzyme, indicating that this system may function as an alternate expression host, especially for genes with a thermophilic origin. To develop further the genetic system for T. saccharolyticum JW/SL-YS485, two improved Escherichia coli-Thermoanaerobacterium shuttle vectors, pRKM1 and pRUKM, were constructed. Furthermore, the kanamycin resistance cassette alone and the kanamycin resistance cassette plus the cellobiohydrolase gene (cbhA) from Clostridium thermocellum JW20 were integrated into the xylanase gene (xynA) region of the Thermoanaerobacterium chromosome via homologous recombination using pUC-based suicide vectors pUXK and pUXKC.