gebhart/patrepeval huggingface dataset:
Wireless Relay Communications with Unmanned Aerial Vehicles: Performance and Optimization (2011)

In this paper, we investigate a communication system in which unmanned aerial vehicles (UAVs) are used as relays between ground-based terminals and a network base station. We develop an algorithm for optimizing the performance of the ground-to-relay links through control of the UAV heading angle. To quantify link performance, we define the ergodic normalized transmission rate (ENTR) for the links between the ground nodes and the relay, and derive a closed-form expression for it in terms of the eigenvalues of the channel correlation matrix. We show that the ENTR can be approximated as a sinusoid with an offset that depends on the heading of the UAV. Using this observation, we develop a closed-form expression for the UAV heading that maximizes the uplink network data rate while keeping the rate of each individual link above a certain threshold. When the current UAV relay assignments cannot meet the minimum link requirements, we investigate the deployment and heading control problem for new UAV relays as they are added to the network, and propose a smart handoff algorithm that updates node and relay assignments as the topology of the network evolves.
Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell (1981)

Essential thrombocythemia is characterized by proliferation of hematopoietic tissue predominantly involving megakaryocytes and resulting in marked thrombocytosis. The disorder has some clinical and laboratory features that resemble those seen in the clonal multipotent stem cell disorders chronic myelogenous leukemia, polycythemia vera, and agnogenic myeloid metaplasia. It has been argued that essential thrombocythemia should be classified together with those disorders as a myeloproliferative syndrome. However, without knowledge of the numbers and types of cells that are involved in essential thrombocythemia, this suggestion remains speculative. Three patients with thrombocytosis were studied. The diagnosis of essential thrombocythemia was considered to be firm in two patients and probable in the third one. The X-linked glucose-6-phosphate dehydrogenase locus was used as a cell marker. Whereas both A and B types of glucose-6-phosphate dehydrogenase were found in nonhematopoietic tissues, only a single-enzyme type was found in the granulocytes, red cells, and platelets from each patient. These data indicate that the disorders in these three patients are clonal and involve multipotent stem cells.
Serum alpha-fetoprotein levels in human disease: perspective from a highly specific monoclonal radioimmunoassay. (1984)

A rapid multisite radioimmunoassay for measurement of human alpha-fetoprotein (AFP) that uses two high-affinity monoclonal antibodies directed against distinct and separate determinants on the protein was developed and designated M-RIA. The sensitivity of the "simultaneous-sandwich" M-RIA is approximately equal to 0.5 ng/ml of serum after a 1-hr incubation period. Serum AFP levels have been measured in 1747 individuals with hepatocellular carcinoma (HCC), acute and chronic hepatitis B virus infection, chronic hepatitis B surface antigen (HBsAg)-carrier states, cirrhosis, other malignant tumors, and normal and disease controls to determine the specificity of the assay. Eighty percent (68/85) of patients with HBsAg-positive HCC had AFP levels of greater than 200 ng/ml (range, 260 to greater than 200,000 ng/ml). In contrast, all 450 normal subjects and 477 chronic HBsAg-positive carriers had levels of less than 20 ng/ml. More importantly, in acute and chronic hepatitis B, cirrhosis, and other malignant tumors and in the remaining disease controls, AFP levels were less than 20 ng/ml in 99.3% of the subjects, the great majority (greater than 96%) being less than 5 ng/ml. Indeed only two of 1635 individuals, one with acute hepatitis and the other with carcinoma of the esophagus had AFP levels of greater than 100 ng/ml. These observations are at variance with previous studies with conventional polyvalent RIAs of AFP levels of greater than 20 ng/ml in approximately equal to 40% of acute and chronic hepatitis and in 30% of cirrhosis. This striking specificity of the M-RIA is probably due in part to recognition of epitopes unique to AFP and suggest that such an assay may be used in the detection, early identification, and monitoring of AFP-producing tumors in high-risk populations.
From Olefins to Alcohols: Efficient and Regioselective Ruthenium‐Catalyzed Domino Hydroformylation/Reduction Sequence (2013)

Exploring the alternatives: Ruthenium imidazoyl phosphine complexes catalyze the domino hydroformylation/reduction of alkenes to alcohols in good yields and with good selectivities (see scheme). Linear aliphatic alcohols are synthesized under reaction conditions typically used in industrial hydroformylations. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Ultrasonic Doppler sensor for speaker recognition (2008)

In this paper we present a novel use of an acoustic Doppler sonar for multi-modal speaker identification. An ultrasonic emitter directs a 40 kHz tone toward the speaker. Reflections from the speaker's face are recorded as the speaker talks. The frequency of the tone is modified by the velocity of the facial structures it is reflected by. The received ultrasonic signal thus contains an entire spectrum of frequencies representing the set of all velocities of facial components. The pattern of frequencies in the reflected signal is observed to be typical of the speaker. The captured ultrasonic signal is synchronously analyzed with the corresponding voice signal to extract specific characteristics that can be used to identify the speaker. Experiments show that the information this can result in significant improvements in speaker identification accuracy both under clean conditions and in noise.
Mechanisms of the Suppression of the Bladder Activity by Flavoxate (1996)

Flavoxate suppressed the micturition reflex primarily by facilitating the inhibitory action of the PoO on the descending pathways from the pontine micturition center to the sacral parasympathetic intermediolateral nuclei.
Neural Matching Models for Question Retrieval and Next Question Prediction in Conversation (2017)

The recent boom of AI has seen the emergence of many human-computer conversation systems such as Google Assistant, Microsoft Cortana, Amazon Echo and Apple Siri. We introduce and formalize the task of predicting questions in conversations, where the goal is to predict the new question that the user will ask, given the past conversational context. This task can be modeled as a "sequence matching" problem, where two sequences are given and the aim is to learn a model that maps any pair of sequences to a matching probability. Neural matching models, which adopt deep neural networks to learn sequence representations and matching scores, have attracted immense research interests of information retrieval and natural language processing communities. In this paper, we first study neural matching models for the question retrieval task that has been widely explored in the literature, whereas the effectiveness of neural models for this task is relatively unstudied. We further evaluate the neural matching models in the next question prediction task in conversations. We have used the publicly available Quora data and Ubuntu chat logs in our experiments. Our evaluations investigate the potential of neural matching models with representation learning for question retrieval and next question prediction in conversations. Experimental results show that neural matching models perform well for both tasks.
Porous Titania Obtained through Polymer Incorporated Composites (1998)

Mesoporous titania with a large surface area has been prepared by calcination of hybrid composites. The composites were obtained by the incorporation of the biopolymer chitosan in titania networks produced from titanium isopropoxide by a sol−gel process. The resultant titania is of the pure anatase form. The effect of the experimental variables on the product's characteristics are studied.
EFFECT OF ELECTRICAL STUNNING ON POSTMORTEM BIOCHEMICAL CHANGES AND TENDERNESS IN BROILER BREAST MUSCLE (1979)

ABSTRACT Two hundred broilers were commercially processed with and without electrical stunning to determine the effect of stunning on biochemical changes and its relationship to final meat tenderness. Electrically stunned birds were more tender with 30% lower shear values than no‐stun controls after 24 hr aging. Breast muscles of electrically stunned birds showed significantly higher ATP, CP and pH, and lower lactate level than no‐stun controls during the early processing steps. It was concluded that electrical stunning inhibited the rapid breakdown of ATP, CP and glycogen, and thus delayed the onset of rigor until after spin‐chill by which time muscle temperature reached 4°C. Consequently, the rigor process occurred at low temperature where potential heat shortening was avoided, resulting in improved meat tenderness.
Interactions between Hedgehog proteins and their binding partners come into view (2010)

Hedgehog (Hh) proteins are secreted signaling molecules that mediate essential tissue-patterning events during embryonic development and function in tissue homeostasis and regeneration throughout life. Hh signaling is regulated by multiple mechanisms, including covalent lipid modification of the Hh protein and interactions with multiple protein and glycan partners. Unraveling the nature and effects of these interactions has proven challenging, but recent structural and biophysical studies of Hh proteins and active fragments of heparin, Ihog, Cdo, Boc, Hedgehog-interacting protein (Hhip), Patched (Ptc), and the monoclonal antibody 5E1 have added a new level of molecular detail to our understanding of how Hh signal response and distribution are regulated within tissues. We review these results and discuss their implications for understanding Hh signaling in normal and disease states.
A candidate live inactivatable attenuated vaccine for AIDS. (1996)

The recent discovery of long term AIDS nonprogressors who harbor nef-attenuated HIV suggests that a naturally occurring live vaccine for AIDS may already exist. Animal models have shown that a live vaccine for AIDS, attenuated in nef, is the best candidate vaccine. There are considerable risks, real and perceived, with the use of live HIV vaccines. We have introduced a conditional lethal genetic element into HIV-1 and simian immunodeficiency virus (SIV) molecular clones deleted in nef. The antiviral strategy we employed targets both virus replication and the survival of the infected cell. The suicide gene, herpes simplex virus thymidine kinase (tk), was expressed and maintained in HIV over long periods of time. Herpes simplex virus tk confers sensitivity to the antiviral activity of acyclic nucleosides such as ganciclovir (GCV). HIV-tk and SIV-tk replication were sensitive to GCV at subtoxic concentrations, and virus-infected cells were eliminated from tumor cell lines as well as primary cell cultures. We found the HIV-tk virus to be remarkably stable even after being cultured in media containing a low concentration of GCV and then challenged with the higher dose and that while GCV resistant escape mutants did arise, a significant fraction of the virus remained sensitive to GCV.
In situ monitoring of second-harmonic generation in human corneas to compensate for femtosecond laser pulse attenuation in keratoplasty (2007)

The application of femtosecond lasers in corneal transplant surgery requires high pulse energies to compensate for the strong optical scattering in pathological corneas. However, excessive energies deteriorate the quality of the incisions. The aim of this study is to demonstrate the dependence of side effects on local radiant exposure, numerical aperture, and tissue properties, to quantify the penetration depth of the laser for individual corneas, and to provide a method for optimizing the energy in the volume of the cornea. We examine histological and ultrastructural sections of clear and edematous corneas with perforating and lamellar incisions performed at different pulse energies. We demonstrate that the augmented energies in edematous corneas may result in unwanted side effects even when using high numerical apertures. The dependence of the laser beam penetration depth on pulse energy is evaluated by histology and an exponential decrease is observed. We show that the penetration length can be determined by evaluating the backscattered second-harmonic emission associated with the nonlinear optical properties of the tissue. This approach represents a noninvasive method for the in situ quantification of the laser beam attenuation, enabling us to adapt the pulse energy accordingly. Experiments using adapted energies show that the side effects are minimized.
Preparation of ductile nickel aluminides for high-temperature uses. [Doping with 500 ppM boron] (1983)

Intermetallic compounds based on nickel and iron aluminides are attractive for structural applications at elevated temperatures. The strong tendency for long range order in these alloys reduces the atomic mobility at elevated temperatures and results in good structural stability and resistance to high-temperature deformation. The major difficulty with using aluminides, such as Ni/sub 3/Al, as structural materials, however, is their tendency for reported brittle intergranular fracture at low temperatures. This brittleness, which effectively precludes fabrication into most structural components, is extremely sensitive to minor variation in alloy preparation. Recent studies have demonstrated that small boron additions greatly improve the ductility of polycrystalline Ni/sub 3/Al. This paper describes a systematic study of microalloying and stoichiometry effects on preparation and fabrication of ductile nickel aluminides. Emphasis is also placed on understanding the chemical aspects of microalloying elements (dopants) on composition and cohesion of grain boundaries in Ni/sub 3/Al.
Comparative genomic analysis of gene variations of two Chinese Yersinia pestis isolates from vaccine strain EV76. (2012)

These findings provide initial insight into the distinct strains isolated from natural foci, within their genomic context, including Yunnan Y. pestis strains. This information will be used therefore to establish subsequent comparisons of these sequences with published complete genomes of other strains.
Toxic Effects of Ergotamine Used for Migraine (1978)

SYNOPSIS Forty‐three patients (6 males and 37 females) who had used ergotamine tartrate 10 mg or more per week continuously over six months were studied. Twenty (47%) of the patients had symptoms and signs compatible with ergotism. This group had not used more ergotamine tartrate than the group, free of symptoms. Of the patients with symptoms, 13 had cardiovascular symptoms and 5 had clinical signs of peripheral neuropathy. Forty‐three per cent of the patients examined had a normal electroencephalogram and the remainder relatively slight abnormalities. Eight patients had signs of peripheral neuropathy in their electroneuromyographic examination., The neurophthalmological examinations were all normal. Eighteen of 23 patients examined psychologically and psychiatrically were characterized as neurotic. Concomitant diseases were more often seen in the group with symptoms of ergotism; it is especially notable that all patients with collagen or diabetic disorders belonged to this group.
T cells cooperating in the induction of delayed-type hypersensitivity act via the linked recognition of antigenic determinants. (1982)

Culture conditions have been established that allow the induction of delayed-type hypersensitivity (DTH) precursor cells present in a cell population derived from unsensitized spleen cells only when antigen-specific, radioresistant, Thy-1-bearing helper cells are added. This specific cellular cooperation acts via the linked recognition of two determinants on the antigen; thus, cells primed to the protein antigen fowl gamma globulin (FGG) will only allow the induction of DTH reactivity against the second antigen, burro erythrocyte (BRBC), when the conjugate FGG-BRBC is present in the cultures. The requirement for physical linkage between the two antigens has been demonstrated by the observation that DTH to BRBC is induced when the conjugate FGG-BRBC is present and not when BRBC and FGG are given an uncoupled molecules.
GEN3VA: aggregation and analysis of gene expression signatures from related studies (2016)

GEN3VA can be used to identify, aggregate, and analyze themed collections of gene expression signatures from diverse but related studies. Such integrative analyses can be used to address concerns about data reproducibility, confirm results across labs, and discover new collective knowledge by data reuse. GEN3VA is an open-source web-based system that is freely available at: http://amp.pharm.mssm.edu/gen3va .
Polymorphisms Associated With Circulating Sex Hormone Levels in Postmenopausal Women (2004)

Genetic variation in CYP19 and SHBG contributes to variance in circulating hormone levels between postmenopausal women, but low r2 values may explain why these genes have given inconclusive results in breast cancer case-control studies.
Particle‐Mediated Gene Delivery In Vivo and In Vitro (1997)

Particle-mediated or "gene gun" technology has been developed as a nonviral method for gene transfer into various mammalian tissues. Gene delivery is achieved by physical force: a strong shock wave is generated that accelerates DNA-coated gold particles to high speeds, providing them with the momentum needed to penetrate the targeted cells. This unit describes general procedures for in vivo and in vitro DNA and RNA transfections by particle-mediated delivery. The Basic Protocol and an alternate protocol address in vivo delivery to mouse skin. In vitro delivery to cryopreserved and adherent cells is also described.
De novo presenilin 1 mutations are rare in clinically sporadic, early onset Alzheimer's disease cases. French Alzheimer's Disease Study Group. (1998)

The presenilin 1 (PS1) gene, located on chromosome 14, is the major gene involved in the autosomal dominant forms of early onset Alzheimer's disease (AD). In order to estimate the frequency of de novo PS1 mutations, we have sequenced the PS1 open reading frame in 13 clinically diagnosed patients with no affected relatives, who had developed AD before the age of 50. In one case with onset at 37 years, we identified a missense mutation resulting in a methionine to lysine substitution at codon 139 of the PS1 gene. This substitution is the fourth identified at the same codon. This study, in agreement with previous reports, suggests that de novo PS1 mutations can occur but at a low frequency.
Massively parallel sequencing for monitoring genetic consistency and quality control of live viral vaccines (2010)

Intrinsic genetic instability of RNA viruses may lead to the accumulation of revertants during manufacture of live viral vaccines, requiring rigorous quality control to ensure vaccine safety. Each lot of oral poliovirus vaccine (OPV) is tested for neurovirulence in animals and also for the presence of neurovirulent revertants. Mutant analysis by PCR and restriction enzyme cleavage (MAPREC) is used to measure the frequency of neurovirulent mutations at the 5' untranslated region (UTR) of the viral genome that correlate with the level of neurovirulence determined by the monkey neurovirulence test. However, MAPREC can only monitor mutations at a few genomic loci and miss mutations at other sites that could adversely affect vaccine quality. Here we propose to use massively parallel sequencing (MPS) for sensitive detection and quantification of all mutations in the entire genome of attenuated viruses. Analysis of vaccine samples and reference preparations demonstrated a perfect agreement with MAPREC results. Quantitative MPS analysis of validated reference preparations tested by MAPREC produced identical results, suggesting that the method could take advantage of the existing reference materials and be used as a replacement for the MAPREC procedure in lot release of OPV. Patterns of mutations present at a low level in vaccine preparations were characteristic of seed viruses used for their manufacture and could be used for identification of individual batches. This approach may represent the ultimate tool for monitoring genetic consistency of live viral vaccines.
A generalized context-based access control model for pervasive environments (2009)

Pervasive Computing Environments enable new opportunities for users to share and to access resources anytime and anywhere in a more natural way, making access control a critical issue. These heterogeneous and dynamic sensor-rich environments characterized by frequent and unpredictable changes on user's, resource's, and environment situations, call for access control solutions that allow dynamically adjust access permissions based on information describing the conditions of these entities (context), such as location and time. Some research attempts have been done based on existing models, which context information is used as an optional attribute for limiting the scope of access control permissions. However, these approaches normally exploit identities and roles dynamically assigned to the users in order to grant access permissions, which is an inappropriate solution for open and dynamic environments which we cannot assume the existence of predefined roles and user-role associations. In this scenario, we claim that access permissions should be assigned to the users only based on context information characterizing the three most important entities of any access control framework: owners, requestors, and resources. Thus, this paper proposes a generalized context-based access control model for making access control decisions completely based on context information.
Emerging blue phase liquid crystal displays (2010)

Device physics and electro-optical properties of emerging polymer-stabilized blue-phase liquid crystal displays (BPLCDs) are investigated. The novel protruded electrodes generate strong horizontal electric fields which penetrate deeply into the bulk LC layer. As a result, the operating voltage is reduced from over 50V<sub>rms</sub> to ~10 V<sub>rms</sub>, which for the first time enables the BP-LCDs to be addressed by amorphous silicon thin-film-transistors (TFTs). Kerr constant effect from the material side is also evaluated quantitatively. Widespread application of TFT BP-LCDs is foreseeable.