gebhart/patrepeval huggingface dataset:
High levels of oncomi<scp>R</scp>‐21 contribute to the senescence‐induced growth arrest in normal human cells and its knock‐down increases the replicative lifespan (2013)

Cellular senescence of normal human cells has by now far exceeded its initial role as a model system for aging research. Many reports show the accumulation of senescent cells in vivo, their effect on their microenvironment and its double-edged role as tumour suppressor and promoter. Importantly, removal of senescent cells delays the onset of age-associated diseases in mouse model systems. To characterize the role of miRNAs in cellular senescence of endothelial cells, we performed miRNA arrays from HUVECs of five different donors. Twelve miRNAs, comprising hsa-miR-23a, hsa-miR-23b, hsa-miR-24, hsa-miR-27a, hsa-miR-29a, hsa-miR-31, hsa-miR-100, hsa-miR-193a, hsa-miR-221, hsa-miR-222 and hsa-let-7i are consistently up-regulated in replicatively senescent cells. Surprisingly, also miR-21 was found up-regulated by replicative and stress-induced senescence, despite being described as oncogenic. Transfection of early passage endothelial cells with miR-21 resulted in lower angiogenesis, and less cell proliferation mirrored by up-regulation of p21(CIP1) and down-regulation of CDK2. These two cell-cycle regulators are indirectly regulated by miR-21 via its validated direct targets NFIB (Nuclear factor 1 B-type), a transcriptional inhibitor of p21(CIP) (1) , and CDC25A, which regulates CDK2 activity by dephosphorylation. Knock-down of either NFIB or CDC25A shows a phenocopy of over-expressing miR-21 in regard to cell-cycle arrest. Finally, miR-21 over-epxression reduces the replicative lifespan, while stable knock-down by sponges extends the replicative lifespan of endothelial cells. Therefore, we propose that miR-21 is the first miRNA that upon its knock-down extends the replicative lifespan of normal human cells.
Prototype semi-transparent photovoltaic modules for greenhouse roof applications (2014)

Improved energy efficiency and the increased use of renewable energy are important objectives for sustainable greenhouse crop production. Two prototypes of semi-transparent-bifacial photovoltaic modules intended for greenhouse roof applications were developed. A module (PV1) using 1500 spherical solar microcells (1.8 mm diameter, crystalline silicon) with 15.4 cells cm−2 density in 108 mm × 90 mm area was produced. Thirty-nine percent of the area was covered with the cells. The remaining 61% was transparent to allow the most sunlight to enter the greenhouse for promising plant photosynthesis. Similarly, a module (PV2) was made using 500 cells with 5.1 cells cm−2 density. Thirteen percent of the area of this module was covered with the cells. The peak power output was 540 mW when the PV1 module was irradiated with 1213 W m−2 sunlight coming directly from the sky and via ground reflection. The peak power output was 202 mW when the PV2 module was irradiated with 1223 W m−2 sunlight. The conversion efficiencies from sunlight energy irradiated on the 108 mm × 90 mm area into electrical energy were 4.5% for the PV1 module and 1.6% for the PV2 module. Calculations of the annual electrical energy production per unit greenhouse land area indicated that these modules are potentially suitable for greenhouses in high-irradiation regions where electricity production could be high and winter demand low.
Collaborative Human-Computer Decision Making for Command and Control Resource Allocation (2007)

Abstract : The focus of this research program was the development of a collaborative human-computer decision-making model that demonstrates not only what decision making functions should always be assigned to humans or computers, but what functions can best be served in a mutually supportive human-computer decision making environment. It is possible that when the human and computer collaborate, they can discover solutions superior to the one either would have determined independently of the other. This research effort investigated the strengths and limitations of both humans and computers in command and control resource allocation problems, and examines how humans and computer can work together collaboratively to promote efficient, effective, and robust decision making.
Adsorption of Surfactant to Bronchial Epithelium: Possible Role of Receptor ‘Unmasking’ in Asthma (2003)

DPPC adsorbs to bronchial epithelium in amounts necessary for the masking of receptors, and this adsorption (probably chemisorption) is quite strongly promoted by PG either in its indigenous state (DPPG) or in the form (EggPG) used in ALECT to suppress the sensitivity of bronchial irritant receptors in our previous study and in clinical trials just completed.
A digital compensation method for improving current transformer accuracy (2000)

This paper deals with error compensation in current transformers. Usually the manufacturer tries to limit these errors by stating a transformer nominal ratio slightly different from the turns ratio. On the other hand techniques have been developed that allow software current compensation. The proposed method requires acquisition of the instantaneous secondary current and its adjustment with magnetizing current, taking into account hysteresis effects. To do this, a preliminary procedure is performed for core and transformer parameter identification. The compensation method has been tested on a variety of instrument transformers, with sinusoidal primary current. Test results show in all examined cases, an improvement in primary current reproduction accuracy, compared with that achieved using CTs nominal ratio, even for core partial saturation. A further development of the compensation technique is in progress, with a view to eliminating some restrictive hypothesis introduced in the present study.
Single and multi-dimensional optimal auctions: a network approach (2004)

This paper highlights connections between the discrete and continuous approaches to optimal auction design with single and multi-dimensional types. We provide an interpretaion of an optimal auction design problem in terms of a linear program that is an instance of a parametric shortest path problem on a lattice. We also solve some cases explicitly in the discrete framework. JEL Classification: C61, C70, D44
Measurement of acoustic impedance and reflectance in the human ear canal (1994)

The pressure reflectance R (omega) is the transfer function which may be defined for a linear one-port network by the ratio of the reflected complex pressure divided by the incident complex pressure. The reflectance is a function that is closely related to the impedance of the 1-port. The energy reflectance R (omega) is defined as magnitude of [R]2. It represents the ratio of reflected to incident energy. In the human ear canal the energy reflectance is important because it is a measure of the inefficiency of the middle ear and cochlea, and because of the insight provided by its simple frequency domain interpretation. One may characterize the ear canal impedance by use of the pressure reflectance and its magnitude, sidestepping the difficult problems of (a) the unknown canal length from the measurement point to the eardrum, (b) the complicated geometry of the drum, and (c) the cross-sectional area changes in the canal as a function of distance. Reported here are acoustic impedance measurements, looking into the ear canal, measured on ten young adults with normal hearing (ages 18-24). The measurement point in the canal was approximately 0.85 cm from the entrance of the canal. From these measurements, the pressure reflectance in the canal is computed and impedance and reflectance measurements from 0.1 to 15.0 kHz are compared among ears. The average reflectance and the standard deviation of the reflectance for the ten subjects have been determined. The impedance and reflectance of two common ear simulators, the Brüel & Kjaer 4157 and the Industrial Research Products DB-100 (Zwislocki) coupler are also measured and compared to the average human measurements. All measurements are made using controls that assure a uniform accuracy in the acoustic calibration across subjects. This is done by the use of two standard acoustic resistors whose impedances are known. From the experimental results, it is concluded that there is significant subject variability in the magnitude of the reflectance for the ten ear canals. This variability is believed to be due to cochlear and middle ear impedance differences. An attempt was made at modeling the reflectance but, as discussed in the paper, several problems presently stand in the way of these models. Such models would be useful for acoustic virtual-reality systems and for active noise control earphones.
CATHODOLUMINESCENCE OF THIN FILMS CONTAINING RARE-EARTH OXIDES (1965)

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Synthetic Peptides Form Ion Channels in Artificial Lipid Bilayer Membranes (1977)

Ion permeability of cell membranes is considered to be mediated by ion channels. The synthesis and testing of four peptides having the sequence (Leu-Ser-Leu-Gly)n and expected to form beta126,6-helical ion channels in lipid bilayer membranes is reported. The two peptides capable of forming helices four turns in length have been demonstrated to form ion channels in an artificial lipid bilayer membrane system. The ion selectivity of the channels is consistent with the predicted beta12-helical model in which ions traversing the channel are coordinated by serine hydroxyl groups arrayed in the interior of the channel.
Phagocytosis of supernumerary spermatozoa by two‐cell mouse embryos (1974)

Abstract Phagocytosis of supernumerary spermatozoa contained within the perivitelline space was observed in 7 of 28 two‐cell mouse embryos cultured for 45 hours post‐insemination (approximately 20–24 hours after cleavage). The spermatozoa were incarcerated as a result of elevations of the blastomere cytoplasm which gradually surrounded the sperm, overlapped and fused, thus forming a typical phagocytic vacuole. Phagocytosis was not observed in two‐cell embryos cultured for less than 20–24 hours after cleavage; this indicates that the blastomeres of two‐cell mouse embryos in vitro require approximately 24 hours to develop one of the characteristics of somatic cells, i.e., the ability to recognize and phagocytize foreign material.
Overlaid Mesh Topology Design and Deadlock Free Routing in Wireless Network-on-Chip (2012)

To bridge the widening gap between computation requirements of terascale application and communication efficiency faced by many-core processor chips, wireless Network-on-Chip (WiNoC) has been proposed by using the recently developed CMOS ultra wideband interconnection. In this research, we propose an unequal RF nodes overlaid mesh topology design to improve the on-chip communication performance. A network capacity model is developed for fast searching of optimal topology configuration. A high-efficient, low-cost zone-aided routing scheme is designed to facilitate deadlock freedom. The simulation study demonstrates topology modeling effectiveness, routing efficiency, and promising network performance of the overlaid mesh WiNoC over a regular 2D mesh baseline.
Anti-immunoglobulin antibodies. III. Properties of sequential anti-idiotypic antibodies to heterologous anti-gamma globulins. Detection of reactivity of anti-idiotype antibodies with epitopes of Fc fragments (homobodies) and with epitopes and idiotopes (epibodies). (1982)

Murine anti-V region antibodies against a human monoclonal protein Gl with anti-gamma-globulin activity and bearing the Wa cross-reactive idiotype were prepared in several strains of mice. Antibodies were obtained that were specific for the Gl idiotype, the Wa cross-reactive idiotype, and for various framework antigenic determinants that were distinguished by a variety of procedures. Synthesis of such antibodies were found to be independent of MHC and Igh gene complexes. These anti-V region antibodies, produced by a majority of mouse strains investigated, also share a cross-reactive idiotype recognized by BALB/c anti-anti-V region Gl antibodies. A fraction of BALB/c anti-anti-V region Gl antibodies displayed human Fc gamma binding activity and, therefore, can be considered homobodies, as described in other systems. Two of the anti-idiotype antibodies obtained in this system exhibited a peculiar property: they interacted not only with their own antigen (IgM Gl), but also with the Fc fragment with which IgM Gl reacts. Thus, A/J anti-V region Gl antibodies bind to the human Fc gamma fragment in addition to IgM Gl. Similarly, a monoclonal CB6 F1 anti-anti-V region Gl antibody interacted with the V region of IgM Gl as well as with the syngeneic anti-V region antibodies. We called these anti-idiotypic antibodies epibodies because they interact with epitopes of the primary antigen. These homobodies and epibodies, obtained by immunization across heterologous barriers, represent new examples of recognition of the internal image of the antigen within the immune system.
Strong Submillimeter Radiation from Intense Relativistic Electron Beams (1974)

Radiation from an intense relativistic electron beam at submillirneter wavelengths has been measured with bandpass and high-pass filters. Radiated power ~100 kW has been measured in the passband 390-540 mu m. The generation of this radiation depends on giving the electrons a large energy component transverse to the magnetic field. Coherent wave generation mechanisms which may account for the observed radiation are discussed.
Discovering and understanding oncogenic gene fusions through data intensive computational approaches (2016)

Although gene fusions have been recognized as important drivers of cancer for decades, our understanding of the prevalence and function of gene fusions has been revolutionized by the rise of next-generation sequencing, advances in bioinformatics theory and an increasing capacity for large-scale computational biology. The computational work on gene fusions has been vastly diverse, and the present state of the literature is fragmented. It will be fruitful to merge three camps of gene fusion bioinformatics that appear to rarely cross over: (i) data-intensive computational work characterizing the molecular biology of gene fusions; (ii) development research on fusion detection tools, candidate fusion prioritization algorithms and dedicated fusion databases and (iii) clinical research that seeks to either therapeutically target fusion transcripts and proteins or leverages advances in detection tools to perform large-scale surveys of gene fusion landscapes in specific cancer types. In this review, we unify these different-yet highly complementary and symbiotic-approaches with the view that increased synergy will catalyze advancements in gene fusion identification, characterization and significance evaluation.
Electromagnetics for high-speed analog and digital communication circuits (2007)

Modern communications technology demands smaller, faster and more efficient circuits. This book reviews the fundamentals of electromagnetism in passive and active circuit elements, highlighting various effects and potential problems in designing a new circuit. The author begins with a review of the basics - the origin of resistance, capacitance, and inductance - then progresses to more advanced topics such as passive device design and layout, resonant circuits, impedance matching, high-speed switching circuits, and parasitic coupling and isolation techniques. Using examples and applications in RF and microwave systems, the author describes transmission lines, transformers, and distributed circuits. State-of-the-art developments in Si based broadband analog, RF, microwave, and mm-wave circuits are reviewed. With up-to-date results, techniques, practical examples, illustrations and worked examples, this book will be valuable to advanced undergraduate and graduate students of electrical engineering, and practitioners in the IC design industry. Further resources for this title are available at www.cambridge.org/9780521853507.
Oral lichen planus and squamous carcinoma: case report and update of the literature. (1991)

A case of squamous cell carcinoma of the tongue arising in the plaque form of oral lichen planus is presented. The literature on lichen planus is reviewed with emphasis upon the malignant transformation.
Advances in infrared optical design via diamond turning technology (1988)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. H. Taylor, "Advances in infrared optical design via diamond turning technology," Optics News 14(6), 28-29 (1988) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Solute Diffusion within Hydrogels. Mechanisms and Models (1998)

Solute diffusion in hydrogels is important in many biotechnology fields. Solute behavior in hydrogels has been explained in terms of reduction in hydrogel free volume, enhanced hydrodynamic drag on the solute, increased path length due to obstruction, and a combination of hydrodynamic drag and obstruction effects. In this article the various mathematical models derived to explain and predict solute diffusion in hydrogels are reviewed and tested against literature data. These models can be divided into those applicable to hydrogels composed of flexible polymer chains (i.e., homogeneous hydrogels) and those composed of rigid polymer chains (i.e., heterogeneous hydrogels). For homogeneous hydrogels it was determined that a scaling hydrodynamic model provided the best explanation for solute diffusion, while for heterogeneous hydrogels obstruction models were more consistent with the experimental data. Both the scaling hydrodynamic model and the most appropriate obstruction model contain undefined parameters which must be clarified in order for these models to gain widespread acceptance.
Self-Assembly of β-Cyclodextrin in Water. Part 1:  Cryo-TEM and Dynamic and Static Light Scattering (2006)

In this article, we report evidence of beta-cyclodextrin (beta-CD) self-aggregation in water. A critical aggregation concentration (cac) between 2 and 3 mM was determined by using dynamic (DLS) and static (SLS) light scattering to investigate the presence of beta-cyclodextrin aggregates. Transmission electron microscopy at cryogenic temperature (Cryo-TEM) was used to detect the structural features of cyclodextrin self-aggregates. The results show the occurrence of polymorphism depending on the beta-CD concentration: polydisperse nearly spherical objects with diameters of about 100 nm are present at lower concentrations, whereas micrometer planar aggregates are predominant at higher concentrations.
High Water Vapor Flux Membranes Based on Novel Diol−Imidazolium Polymers (2010)

A breathable membrane that demonstrates high water vapor flux was prepared using a diol-functionalized polymerizable room temperature ionic liquid. A novel monomer material was synthesized and used to fabricate thin films which were tested for their ability to transport water vapor. These materials were tested beside commercial breathable polymers for comparison.
Thermal and Electrical Properties of Tungsten Oxide (WO<sub>3</sub>) (1956)

Thermal and electrical properties of tungsten oxide were observed in a wide range of temperature. An entirely new anomaly was found at 1230°C, where the rate of sublimation increased abruptly. The amounts of anomalous heat were found to be 330, 450, 280 and 120 cal/mol at the 330°C, 740°C, 910°C and 1230°C transitions respectively, the entropy change being 0.55, 0.45, 0.23 and 0.08 cal/mol·deg at each of the transition temperatures. Any anomalous heat larger than 6 cal/mol was not observed near the -20°C transition point. At the mentioned transition points the anomalies of electrical properties were observed. The d.c. resistance decreases, on heating from room temperature, like a typical semiconductor with the activation energies of nearly 2.2, 0.3, 1.7 and 1.3 eV below 740°C, between 740°C and 910°C, between 910°C and 1230°C and above 1230°C, respectively, the small value as 0.3 eV between 740°C and 910°C being especially noticeable. A non-linearly of I - V relation was observed, indicating some anomalous electrical property of this substance.
A calculus for computing Filippov's differential inclusion with application to the variable structure control of robot manipulators (1986)

This paper develops a calculus for computing Filippov's differential inclusion which simplifies the analysis of dynamical systems described by differential equations with discontinuous right-hand-side. In particular, when a slightly generalized Lyapunov theory is used, the rigorous stability analysis of variable structure systems is routine. As an example, a variable structure control law for rigid-link robot manipulators is described and its stability is proved.
Acoustic Source Localization (2013)

Source Localization is a very well established technique that has a wide range of applications from remote sensing to the Global Positioning System. Sound source localization techniques are used in commercial applications like improving speech quality in hands free telephony, video conferencing to military applications like SONAR, surveillance systems and devices to locate the sources of artillery fire. A method is proposed to localize an acoustic source within a frequency band from 100Hz to 4 KHz in two dimensions using microphone array by calculating the direction of arrival (DOA) of the acoustic signals. Direction of arrival (DOA) estimation of acoustic signals using a set of spatially separated microphones uses the phase information present in signals. For this the time-delays are estimated for each pair of microphones in the array. From the known array geometry and the direction of arrival, the location of source can be obtained.