gebhart/patrepeval huggingface dataset:
1′-Acetoxychavicol Acetate Isolated from Alpinia galanga Ameliorates Ovalbumin-Induced Asthma in Mice (2013)

The World Health Organization reports that 235 million people are currently affected by asthma. This disease is associated with an imbalance of Th1 and Th2 cells, which results in the upregulation of cytokines that promote chronic inflammation of the respiratory system. The inflammatory response causes airway obstruction and can ultimately result in death. In this study we evaluated the effect of 1'-acetoxychavicol acetate (ACA) isolated from Alpinia galanga rhizomes in a mouse model of ovalbumin (OVA)-induced asthma. To generate the mouse model, BALB/c mice were sensitized by intraperitoneal injection of OVA and then challenged with OVA inhalation for 5 days. Mice in the vehicle control group were sensitized with OVA but not challenged with OVA. Treatment groups received dexamethasone, 25 mg/kg/day ACA, or 50 mg/kg/day ACA for 5 days. Asthma-related inflammation was assessed by bronchoalveolar lavage fluid cell counts and histopathological and immunohistochemical analysis of lung tissues. Our results showed that ACA reduced the infiltration of white blood cells (especially eosinophils) and the level of IgE in the lungs of mice challenged with OVA and suppressed histopathological changes such as airway remodeling, goblet-cell hyperplasia, eosinophil infiltration, and glycoprotein secretion. In addition, ACA inhibited expression of the Th2 cytokines interleukin (IL)-4 and IL-13, and Th1 cytokines IL-12α and interferon-γ. Because asthmatic reactions are mediated by diverse immune and inflammatory pathways, ACA shows promise as an antiasthmatic drug candidate.
Closure of the Cavity in Permethylated Cyclodextrins through Glucose Inversion, Flipping, and Kinking (1998)

Glucose-flips in a small cycloamylose: the molecular structure of permethylated γ-cyclodextrin, which crystallizes as the dihydrate, is characterized by 180° flips of two diametrically opposed glucose residues. This leads to an elliptical distortion of the molecule and closure of the molecular cavity on one side so that it is no longer doughnut-shaped but is bowl-shaped. The hydrate water molecules are not located in the cavities!
Nitroreductase activity of NADH dehydrogenase of the respiratory redox chain (1989)

1. An NADH-dependent nitroreductase from the inner membrane of ox liver mitochondria copurified with Complex I of the respiratory redox chain (NADH:ubiquinone oxidoreductase, EC 1.6.5.3). 2. The corresponding nitroreductase from ox heart mitochondria co-purified with the NADH-cytochrome c reductase of Mahler, Sarkar & Vernon [(1952) J. Biol. Chem. 199, 585-597] [NADH: (acceptor) oxidoreductase, EC 1.6.99.3], a component of Complex I that contains the FMN. 3. The mitochondrial nitroreductase activity is attributed to the flavoprotein component of Complex I.
Low Background, Pulsatile, In Vitro Flow Circuit for Modeling Coronary Implant Thrombosis (2002)

We have developed an in vitro method for creating pulsatile flows to mimic coronary type flow patterns on a beat-to-beat basis. The flow is created by accelerating fluid loops about an axis, inducing relative wall motion. Using this technique, a variety of oscillating flow patterns can be generated and modulated. Such flow generation offers the potential to monitor sensitive, flow-dependent, biological parameters like thrombosis while minimizing background disturbances from pump action and circuit effects. We examined this potential by measuring the loop occlusion time for loops stented with stainless steel 7-9 NIR stents and stentless control loops.
Rheological Properties of a Particulate-Filled Polymeric Composite through Fused Deposition Process (2010)

This paper presents an investigation on rheological properties of a new ABS (acrylonitrile-butadiene-styrene)-Iron composite for application in Fused Deposition Modelling rapid prototyping process. Test samples of ABS-Iron composites have been made by controlled centrifugal mixing and thermal compounding through a single-screw extruder and compression moulding. Rheological characterization was conducted using a capillary rheometer by measuring pressure drop at the die while varying the extrusion speed. Apparent shear rate and shear stress as well as viscosity of the melts were calculated. Modulated differential-scanning calorimetry (MDSC) techniques were used in order to characterize viscoelastic properties of these newly developed composites materials. Non-Newtonian behaviour of the composite melt has shown to follow a cross model of shear thinning characteristics.
Remarkably efficient inhaled antifungal monotherapy for invasive pulmonary aspergillosis: Figure 1– (2012)

Remarkably efficient inhaled antifungal monotherapy for invasive pulmonary aspergillosis
Bayesian Methods in Virtual Screening and Chemical Biology (2010)

The Naïve Bayesian Classifier, as well as related classification and regression approaches based on Bayes' theorem, has experienced increased attention in the cheminformatics world in recent years. In this contribution, we first review the mathematical framework on which Bayes' methods are built, and then continue to discuss implications of this framework as well as practical experience under which conditions Bayes' methods give the best performance in virtual screening settings. Finally, we present an overview of applications of Bayes' methods to both virtual screening and the chemical biology arena, where applications range from bridging phenotypic and mechanistic space of drug action to the prediction of ligand-target interactions.
Adsorptive Separation of Acetic Acid from Dilute Aqueous Solutions: Adsorption Kinetic, Isotherms, and Thermodynamic Studies (2015)

ZSM-5 (Zeolite Scony Moblie-5) (SiO2/Al2O3 = 360, 470), NaY, 13X (pellet, powder) and coconut shell activated carbon (YK-AC) are employed for acetic acid separation from dilute aqueous solutions via adsorption. Zeolite 13X exhibits a much higher adsorption capacity than other zeolites and activated carbon. The effects of adsorption time and different initial acetic acid concentrations were studied. At 71.77 g·kg–1, the initial acetic acid concentration, 13X in pellet exhibited the highest uptake capacity of 354.03 mg·g–1 at 318 K. Meanwhile, adsorption equilibrium, kinetics, and thermodynamics of an acetic acid aqueous solution on zeolite 13X in pellet were studied in batch experiments. Kinetic models such as pseudo-first-order, pseudo-second-order, and Elovich have been used to describe the adsorption behavior of zeolite 13X in pellet. Pseudo-second-order was found the most suitable for this system. Langmuir and Freundlich isotherm models were applied to experimental data depending on temperature. The Freundlich isotherm fitted the experimental data better than the Langmuir isotherm for adsorption of acetic acid. Using the thermodynamic equilibrium coefficients obtained at different temperatures, the thermodynamic constants (ΔG, ΔH, and ΔS) of adsorption were also calculated, and the results indicated that the adsorption process of acetic acid on zeolite 13X in pellet was spontaneously endothermic.
Dual Rate Jounce Bumper Design (2011)

<div class="section abstract"><div class="htmlview paragraph">Jounce bumpers are the primary component by which vertical wheel travel is limited in our suspensions. Typically, the jounce bumper is composed of closed or open cell urethane material, which has relatively low stiffness at initial compression with highly progressive stiffness at full compression. Due to this highly progressive stiffness at high load, peak loads are extremely sensitive to changes in input energy (affected by road surface, tire size, tire pressure, etc.) A “Dual Rate Jounce Bumper” concept is described that reduces this sensitivity. Additionally, various mechanizations of the concept are described as well as the specific program benefits, where applicable.</div></div>
Multilevel HfO2-based RRAM devices for low-power neuromorphic networks (2019)

Training and recognition with neural networks generally require high throughput, high energy efficiency, and scalable circuits to enable artificial intelligence tasks to be operated at the edge, i.e., in battery-powered portable devices and other limited-energy environments. In this scenario, scalable resistive memories have been proposed as artificial synapses thanks to their scalability, reconfigurability, and high-energy efficiency, and thanks to the ability to perform analog computation by physical laws in hardware. In this work, we study the material, device, and architecture aspects of resistive switching memory (RRAM) devices for implementing a 2-layer neural network for pattern recognition. First, various RRAM processes are screened in view of the device window, analog storage, and reliability. Then, synaptic weights are stored with 5-level precision in a 4 kbit array of RRAM devices to classify the Modified National Institute of Standards and Technology (MNIST) dataset. Finally, classification performance of a 2-layer neural network is tested before and after an annealing experiment by using experimental values of conductance stored into the array, and a simulation-based analysis of inference accuracy for arrays of increasing size is presented. Our work supports material-based development of RRAM synapses for novel neural networks with high accuracy and low-power consumption.
Performance Evaluation of Hybrid Reconfigurable Computing Architecture over Symmetrical FPGA (2012)

For last few decades, reconfigurable devices have been extensively used in digital systems. Reconfigurable computing using FPGA devices provide a method to utilize the available logic resources on the chip for various computations. The basic ability of reconfigurable computing is to perform computations in hardware to increase performance, while retaining the flexibility of application software. The two main types of programmable logic devices, field-programmable gate arrays (FPGA) based on LUTs technology and complex programmable logic device (CPLD) based on PLAs technology. They are both widely used and each contributing particular strengths in the area of reconfigurable system design. We identified Hybrid LUTs/PLAs architectures as Hybrid Reconfigurable Computing Architectures (HRCA). The purpose of this paper is to evaluate the performance of HRCA over regular FPGA device for reconfigurable computing by mixing of Look up tables (LUTs) and Programmable logic arrays (PLAs) architecture. The basis of the HRCA is that some parts of digital circuits are well-suited for execution with LUTs, but other parts help more from the PLAs structures. For several classes of high performance applications, HRCA offers significant savings in total computational delay comparison with a symmetrical FPGA which contain only LUTs. It also offers some improvements in logical area and power consumption. Experimental results based on MCNC benchmark circuit were performed on implemented HRCA CAD and compare between HRCA and symmetrical FPGA. Initially results indicate that noteworthy saving in computational delay and logic area of HRCA over symmetrical FPGA.
Associative processors for video coding applications (2006)

Associative processors are single-instruction multiple-data-based architectures that provide huge parallelism which can be very useful for processing video in real time. This paper describes architectural requirements for video and shows that associative processors are ideally suited for applications involving video. Some routines like discrete cosine transforms (DCTs) lack required parallelism and their implementation becomes critical for the overall performance of the processor for video. We present three different approaches for computing two-dimensional DCT on associative processors and discuss their implementation details. Many methods like conditional execution of DCT, have been suggested in literature for power efficiency. In this paper, we discuss integration of these techniques in our implementation. Finally, performance of Associative processors is compared with that of RISC and DSP processor and show that associative processors are better suited for processing video both in terms of speed and power.
Comparison of simulation and measurement for 1-D metamaterial devices (2005)

We have conducted numerical and experimental studies of a simple metamaterial structure formed from 'C' shaped copper rings. Our study focuses on the investigation of the individual resonant elements by surface current and Q factor. We have also analysed wavelike signal propagation along these structures' axes recently predicted theoretically - so called magneto-inductive waves (MIWs). Computer based finite difference electromagnetic methods have been employed to both visualize the surface currents and investigate the effects of varying coupling within the structures. Experimental work has closely followed the theoretical work with measurements carried out using a Vector Network Analyzer to determine the frequency dependent scattering parameters. Applications of these structures are also considered in our work and the aim is to develop a robust, reliable design tool that enables rapid determination of the appropriate dimensions to enable operation of a magneto-inductive waveguide at a desired frequency. The simulation work demonstrates the possibilities for wave propagation in curved guides formed from stacks and rows of elements. And these may form the basis for a new class of microwave filter offering tunability and flexibility and requiring no direct connections to the driving circuits.
Mechanism and inhibition of cytochrome P-450 aromatase (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism and inhibition of cytochrome P-450 aromatasePhilip A. Cole and Cecil H. RobinsonCite this: J. Med. Chem. 1990, 33, 11, 2933–2942Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/jm00173a001https://doi.org/10.1021/jm00173a001research-articleACS PublicationsRequest reuse permissionsArticle Views691Altmetric-Citations263LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel nasal In situ gelling system for treatment of sinusitis (2009)

In situ gelling systems based on temperature-dependent phase transition containing pheniramine and phenylephrine were developed using combination of Poloxamers, different cellulose polymers (HPMC) and xanthan gum. The formulations were tested for in vitro gelation, appearance, pH, drug content, in vitro drug release, mucoadhesive strength, preservative efficacy and stability. In vitro release studies revealed significant prolonged released of both drugs up to 24 h as against only 2 h with drug solution. Formulations were found to stable over period of 3 months. In vivo nasal residence time of in situ gel by gamma scintigraphy was found to be significantly higher (6 h) in comparison to drug solution (15 min). It can be concluded that Poloxamers in combination with HPMC are suitable to develop stable, safe in situ temperature-based mucoadhesive gelling systems with prolonged nasal residence time.
Overview: War, Crisis, and Transition (2008)

Newly elected PresideNt Barack OBama faces the thaNkless task Of rescu-ing the key financial and productive institutions of American capitalism, reforming and strengthening international financial institutional arrange-ments, extricating the country from two hot wars and countless worldwide military entanglements, and putting in place a non-carbon energy architecture sufficiently robust to save the planet from a meltdown. Many of these underlying issues form the substance of contributions to this edition of Social Justice. President Obama must also restore the image of the United States, which was badly tarnished by the Bush administration’s abandonment of the Geneva Conventions, the rule of law, and multilateralism, all of which were compounded by extra-constitutional abuses of power at home. To introduce meaningful change that “we can believe in,” Obama must take on a powerful financial oligarchy, the energy monopolies, and the military-industrial complex. Much has already been accomplished, but unless he changes course, his two greatest mistakes may be his management of the banking crisis and his expansion of the war in Afghanistan to Pakistan, programs begun under George W. Bush, but which are acquiring Obama’s imprint as time passes. Obama’s presidency represents a period of transition, a new departure conditioned
Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies (2005)

Recombinant human ceramide kinase (HsCERK) was analyzed with regard to dependence on divalent cations and to substrate delivery, spectrum, specificity, and stereoselectivity. Depending on the chain length of the ceramide, either albumin for short-chain ceramide or a mixed micellar form (octylglucoside/cardiolipin) for long-chain ceramide was preferred for the substrate delivery, the former resulting in higher activities. Bacterially expressed HsCERK was highly dependent on Mg2+ ions, much less on Ca2+ ions. A clear preference for the d-erythro isomer was seen. Various N-acylated amino alcohols were no substrate, but N-hexanoyl-1-O-hexadecyl-2-desoxy-2-amino-sn-glycerol and N-tetradecanoyl-2S-amino-1-butanol were phosphorylated, suggesting that the secondary hydroxy group is not required for recognition. The properties of HsCERK, expressed in CHO cells, were similar to those of the bacterially expressed protein, including the Mg2+ dependence. In mouse, the highest activities were found in testis and cerebellum, and upon subcellular fractionation the activity was recovered mainly in the microsomal fraction. This fits with the plasma membrane localization in CHO cells, which was mediated by the N-terminal putative pleckstrin domain. No evidence for phosphorylation of ceramide by the recently described multiple lipid kinase was found. The latter kinase is localized in the mitochondria, but no firm conclusions with regard to its substrate could be drawn.
Device characterization of high-electron-mobility transistors with ferroelectric-gate structures (2002)

Fabrications and characterizations of high electron-mobility transistors (HEMTs) with a ferroelectric gate (F-HEMTs) are presented. The F-HEMT is a memory device whose threshold voltage can be changed even after it is fabricated, by using remanent polarization of the ferroelectric gate. Furthermore, the F-HEMT is promising of neural network applications, because it can act as a high-speed analog memory which stores synaptic weights in a neuron circuit. From I/sub D/-V/sub G/ characteristic measurements of F-HEMTs, it is demonstrated that the threshold voltage is shifted by 0.3 V by remanent polarization. The result indicates that F-HEMTs are sufficiently applicable for the high-speed analog memory.
10Gbit/s Amplified Reflective Electroabsorption Modulator for Colourless Access Networks (2006)

For high speed remote colorless modulation in FTTH technology, a new 10Gbit/s monolithically integrated amplified reflective electroabsorption modulator (R-EAM-SOA) is demonstrated over 50nm spectral range and over 20°C-60°C, with excellent eye diagrams.
Surface graft polymerization of conducting polyaniline on waterborne poyurethane‐urea film and its phenol sensing (2012)

Abstract Waterborne polyurethane‐ureas (pristine WBPUs: WBPU‐19 and WBPU‐24, fixed soft segment content: 60 wt %) containing dimethylol propionic acid (DMPA)/ethylene diamine (EDA) contents (19/16.8 and 24/11.4 mol %) were prepared. The polyaniline (PANI)‐ graft ‐WBPU (PANI‐ graft ‐WBPU) films were prepared by oxidative graft polymerization of aniline on the surface layer of WBPU films. This study focused on the effects of reaction conditions (concentrations/treating times/temperatures of aniline and APS) and DMPA content on the %grafting, conductivity, and mechanical properties of PANI‐ graft ‐WBPU films. To obtain the maximum %grafting (PANI‐ graft ‐WBPU‐19: 6.2, and PANI‐ graft ‐WBPU‐24: 7.4) and conductivity (PANI‐ graft ‐WBPU‐19: 3.6 × 10 −2 S/cm, and PANI‐ graft ‐WBPU‐24: 4.7 × 10 −2 S/cm), the optimum concentrations/treating times/temperatures of aniline and APS, were found to be 0.35 M /10 min/25°C and 0.2 M /10 min/0°C, respectively. The tensile strength of film samples was found to be increased in the order of PANI‐ graft ‐WBPU‐19>pristine WBPU‐19>PANI‐ graft ‐WBPU‐24>pristine WBPU‐24. The PANI‐ graft ‐WBPU‐19 (%grafting: 6.2) films on exposure to 0–10,000 ppm phenol solutions showed a well‐defined response behavior, demonstrating high promise for application in aqueous phenol sensors. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
A Patch-type Wireless Physiological Monitoring Microsystems (2007)

We developed a patch-type wireless multi-sensor system for physiological signals monitoring which is able to apply to tele-home-care or any related application. The module "tag", without any constraint of the belt, is attached to the belly and is easy to measure the skin temperature, ECG signals, and respiration at the same time and show by "computer information center". The Tag consists of three parts: a thermistor, an accelerometer, and electrocardiogram electrodes. In order to make the flexible module, the substrate adopts the soft PI with two conductive layers and the active and passive components are carefully selected.
Poliovirus type 3: molecular cloning of the genome and nucleotide sequence of the region encoding the protease and polymerase proteins (1983)

Overlapping cDNA clones representing the entire genome of poliovirus type 3 have been prepared in E. coli by two separate methods. Cloning of RNA . cDNA hybrids produced a more comprehensive set of clones with generally larger cDNA inserts than cloning of double - stranded cDNA. A restriction map of the entire genome and the nucleotide sequence of 2003 bases from the 3' terminus, comprising the region encoding the protease and polymerase proteins, are presented.
[Changes in the levels of various substrates of nitrogen metabolism and tricarboxylic acid cycle during experimental acidosis in calves]. (1987)

The effect of experimental metabolic acidosis and its correction for nitrogen and energy metabolism was studied in new-born calves. It was discovered that a change in the acid-base balance towards acidosis causes a sharp increase in "ammoniogenesis", urea formation and inhibition of the tricarboxylic acid cycle, which is also observed in calves suffering from dyspepsia with symptoms of acute diarrhea. Alongside with the use of therapeutic measures for treating dyspepsia of new-born calves, it is necessary to control the acid-base balance of blood in the calves and in case of revealing the acidosis state to use means of its correction.