gebhart/patrepeval huggingface dataset:
Granulation Surface Area as Basis for Magnesium Stearate Concentration in Tablet Formulations (1986)

Tablets provide drug delivery in a convenient and uncomplicated manner. Despite this apparent simplicity, they must comply with a formidable number of physico-chemical compendial requirements defined by specifications and test methods. What these specifications indirectly control is that each dosage form or each lot of dosage form my vary but the variance is held within stated limits.This communication focuses on the weight variation of formulation ingredients that my be allowed in general and for magnesium stearate in particular and to define a relationship between the lubricant level and granulation surface area of a calcium phosphate matrix to obtain optimal tablet properties.
A passive approach to sensor network localization (2005)

Sensor networks present the opportunity to accurately localize the phenomena of interest. To be able to do so however, sensor nodes, need themselves to be accurately localized. We present an algorithm to do this based on uncontrolled environmental sounds observed by each of the sensor nodes. A probabilistic generative model is presented and it is shown that the sensor node localization problem is equivalent to maximum likelihood estimation in the model. Experimental results are presented for both simulated sensor nodes and Crossbow MICA2 sensor nodes.
Fine Structure in the Energy Region of the Isoscalar Giant Quadrupole Resonance: Characteristic Scales from a Wavelet Analysis (2004)

Fine structure in the energy region of the isoscalar giant quadrupole resonance in nuclei is observed in high-resolution proton scattering experiments at iThemba LABS over a wide mass range. A novel method based on wavelet transforms is introduced for the extraction of scales characterizing the fine structure. A comparison with microscopic model calculations including two-particle two-hole (2p2h) degrees of freedom identifies the coupling to surface vibrations as the main source of the observed scales. A generic pattern is also found for the stochastic coupling to the background of the more complex states.
Knowledge Graph and Text Jointly Embedding (2014)

We examine the embedding approach to reason new relational facts from a largescale knowledge graph and a text corpus. We propose a novel method of jointly embedding entities and words into the same continuous vector space. The embedding process attempts to preserve the relations between entities in the knowledge graph and the concurrences of words in the text corpus. Entity names and Wikipedia anchors are utilized to align the embeddings of entities and words in the same space. Large scale experiments on Freebase and a Wikipedia/NY Times corpus show that jointly embedding brings promising improvement in the accuracy of predicting facts, compared to separately embedding knowledge graphs and text. Particularly, jointly embedding enables the prediction of facts containing entities out of the knowledge graph, which cannot be handled by previous embedding methods. At the same time, concerning the quality of the word embeddings, experiments on the analogical reasoning task show that jointly embedding is comparable to or slightly better than word2vec (Skip-Gram).
Hot <i>and</i> Cold TRP Ion Channels (2002)

Tasting menthol evokes a cool sensation. In his Perspective,
 Clapham
 discusses new work published elsewhere that identifies a TRP ion channel, which is opened by both cold temperature and menthol. The channel is expressed in neurons of the trigeminal and dorsal root ganglia that receive sensations from regions such as the mouth and in the skin.
Extendable carrier synchronization for distributed beamforming in wireless sensor networks (2016)

Transmit beamforming is a traditional technique for multi-antenna network. Recently, idea of beamforming is applied in wireless sensor network, which can extent its communication distance significantly. An extendable scheme is proposed for carrier synchronization of distributed beamforming in this paper. All slave nodes adjust local oscillation with the selected master node's oscillation to synchronize carrier frequency. Phase is synchronized at receiving terminal by means that master node rollover signal from each slave node and send it back to counteract phase differences. Simulation is given to analyze its performance. Results show that signal is strengthened at receiving terminal. Besides, circuit prototype is recommended. Effects of node mobility are discussed.
12-GHz -Band FM Receiver for Satellite Broadcasting (1978)

This paper describes the low-noise low-cost receiver for satellite broadcasting with new technology developed by us. The paper also describes the image recovery theory, the design principle of our downconverter, a frequency-stabilized local oscillator with bipolar transistors, the required limiting factor of a filter, the removing circuit of an energy dispersal signal, and a parabolic antenna for circularly polarized waves together with the performance of our device. The experimental results obtained through the Communication Technology Satellite (CTS) are also shown.
Biodegradable Tetra-PEG Hydrogels as Carriers for a Releasable Drug Delivery System (2015)

We have developed an approach to prepare drug-releasing Tetra-PEG hydrogels with exactly four cross-links per monomer. The gels contain two cleavable β-eliminative linkers: one for drug attachment that releases the drug at a predictable rate, and one with a longer half-life placed in each cross-link to control biodegradation. Thus, the system can be optimized to release the drug before significant gel degradation occurs. The synthetic approach involves placing a heterobifunctional connector at each end of a four-arm PEG prepolymer; four unique end-groups of the resultant eight-arm prepolymer are used to tether a linker-drug, and the other four are used for polymerization with a second four-arm PEG. Three different orthogonal reactions that form stable triazoles, diazines, or oximes have been used for tethering the drug to the PEG and for cross-linking the polymer. Three formats for preparing hydrogel-drug conjugates are described that either polymerize preformed PEG-drug conjugates or attach the drug postpolymerization. Degradation of drug-containing hydrogels proceeds as expected for homogeneous Tetra-PEG gels with minimal degradation occurring in early phases and sharp, predictable reverse gelation times. The minimal early degradation allows design of gels that show almost complete drug release before significant gel-drug fragments are released.
Analysis and design of distributed ESD protection circuits for high-speed mixed-signal and RF ICs (2002)

Electrostatic discharge (ESD) protection devices can have an adverse effect on the performance of high-speed mixed-signal and RF circuits. This paper presents quantitative methodologies to analyze the performance degradation of these circuits due to ESD protection. A detailed S-parameter-based analysis of these high-frequency systems illustrates the utility of the distributed ESD protection scheme and the impact of the parasitics associated with the protection devices. It is shown that a four-stage distributed ESD protection can be beneficial for frequencies up to 10 GHz. In addition, two generalized design optimization methodologies incorporating coplanar waveguides are developed for the distributed structure to achieve a better impedance match over a broad frequency range (0-10 GHz). By using this optimized design, an ESD device with a parasitic capacitance of 200 fF attenuates the RF signal power by only 0.27 dB at 10 GHz. Furthermore, termination schemes are proposed to allow this analysis to be applicable to high-speed digital and mixed-signal systems.
Tutorial: real-time object-oriented modeling (ROOM) (2002)

Developing real time software is particularly challenging since the complexity of the physical world has to be accommodated as well as stringent resource and timeliness constraints. Such circumstances require special language support over and above what can be found in general purpose programming languages. ROOM is both an object oriented modeling language and a development method specifically designed for dealing with large real time systems. It supports automatic code generation to ensure reliability and increase productivity.
[Late improvements in chronic schizophrenics]. (1985)

The author raises the issue of patients' late improvement with chronic schizophrenia. Five out of 289 reassessed chronic schizophrenics--1.7% of that population--have been found improved. Two cases are described in detail and finally some hypotheses are suggested in relation to the possible mechanisms underlying these rare courses of schizophrenia.
Clinical Validation of an Ultra High-Throughput Spiral Microfluidics for the Detection and Enrichment of Viable Circulating Tumor Cells (2014)

We have clinically validated our multiplexed microfluidic chip for the ultra high-throughput, low-cost and label-free enrichment of CTCs. Retrieved cells were unlabeled and viable, enabling potential propagation and real-time downstream analysis using next generation sequencing (NGS) or proteomic analysis.
Trends in Music Education Research in Australian with Implications and Recommendations for the Twenty-first Century (1998)

This paper reports on the current state of 'award' research in music education in Australia using data from the 'Bibliography of Australian Music Education Research' (BAMER) Project. The findings from an analysis of data from approximately 350 research theses - including both 'completed' and 'in-progress' studies - undertaken for higher degrees at Australian tertiary institutions are discussed. Conclusions are drawn regarding the level of the higher degree work being undertaken (honours, masters and doctoral degrees), the demographic spread across the various states, the distribution of music education research across the major educational research paradigms, and the focus of research in relation to both content/subject and educational sector. The paper also identifies general trends and issues in relation to these aspects as well as making recommendations for promoting research as we approach the new millennium.
Viewing complex scenes with error-buffered light fields (2002)

This paper describes a new method for view synthesis from previously generated images. The method considers each image to be a slice of an overall light field which describes radiance as a function of position and direction. Each slice is then mapped onto the viewing parameters of a new slice as an orthogonally projected, texture-mapped, deformed surface whose z-values correspond to the disparity between rays passing through a given pixel. As a result, the slice can be sent to a traditional z-buffered texture-mapping graphics pipeline, wherein each pixel's depth corresponds to its error Therefore the z-buffer will implicitly select for each pixel the best match. We call this technique error-buffering (or /spl epsi/-buffering).
2'-Deoxynucleoside Dithiophosphates: Synthesis and Biological Studies1 (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2'-Deoxynucleoside Dithiophosphates: Synthesis and Biological Studies1Peter H. Seeberger, Eric Yau, and Marvin H. CaruthersCite this: J. Am. Chem. Soc. 1995, 117, 5, 1472–1478Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/ja00110a002https://doi.org/10.1021/ja00110a002research-articleACS PublicationsRequest reuse permissionsArticle Views392Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Dana's System of Mineralogy. 7. Ed (1952)

"Dana's System of Mineralogy. 7. Ed." Geologiska Föreningen i Stockholm Förhandlingar, 74(2), pp. 218–219
Phospholipase D activation in human natural killer cells through the Kp43 and CD16 surface antigens takes place by different mechanisms. Involvement of the phospholipase D pathway in tumor necrosis factor alpha synthesis. (1992)

We have recently described a novel glycoprotein, Kp43, expressed on the surface of human natural killer (NK) cells that appears to regulate their functional activity. In this report, signaling mechanisms through the Kp43 surface antigen have been studied. Incubation of interleukin 2 (IL-2)-treated NK cells with anti-Kp43 monoclonal antibody F(ab')2 fragments resulted in the time- and dose-dependent stimulation of NK cell phospholipase D. Phospholipase D activation through the Kp43 surface antigen was found to take place in the absence of polyphosphoinositide turnover and appeared not to depend on the presence of Ca2+ in the extracellular medium. On the other hand, signaling mechanisms through the CD16 receptor (FcR-III) on NK cells were comparatively studied. Stimulation of IL-2-treated NK cells with anti-CD16 monoclonal antibody F(ab')2 fragment also resulted in time- and dose-dependent activation of phospholipase D. However, CD16-triggered phospholipase D activation took place concomitant to phospholipase C-mediated polyphosphoinositide breakdown and showed a strong dependence on extracellular Ca2+. These results provide, to our knowledge, the first evidence for the presence of activatable phospholipase D in NK cells, as well as the first indication that distinct receptor-modulated pathways exist for activation of phospholipase D within the same cell type. On the other hand, phosphatidic acid, the physiologic product of phospholipase D action on phospholipids, was found to mimic the effect of anti-Kp43 monoclonal antibody regarding tumor necrosis factor alpha (TNF-alpha) biosynthesis and secretion by NK cells. Addition of phosphatidic acid vesicles to IL-2-treated NK cell cultures stimulated a TNF-alpha production that was abolished when the cells were previously treated with actinomycin D. Other phospholipids, including lysophosphatidic acid, were ineffective. However, phosphatidic acid-induced TNF-alpha production was strongly inhibited by the presence of propranolol, an inhibitor of phosphatidic acid phosphohydrolase. Moreover, in cells responding to phorbol myristate acetate, a compound that triggers activation of phospholipase D, TNF-alpha synthesis was also inhibited by propranolol. Thus, these data suggest a second messenger role for phosphatidic acid-derived diradylglycerol in the induction of TNF-alpha gene expression.
Antibody to the oxyphil cells of the human parathyroid in idiopathic hypoparathyroidism. (1969)

IgG antibody to parathyroid oxyphil cells is described in the serum of one of nine patients with idiopathic hypoparathyroidism. This serum also reacted with the chief cells of the parathyroid. Whether other sera from the patients with hypoparathyroidism contained antibody to chief cells in low titre was uncertain.
Count, size and visualize nanoparticles (2011)

Nanoscale materials including nanotubes, nanowires, ceramics, quantum dots etc. can be produced from a huge variety of substances. Responsible development of new materials requires that risks to health and the environment associated with the development, production, use and disposal of these materials are fully addressed. Characterization of particles at the nanoscale thus becomes extremely important and new tools are being made available including the nanoparticle characterization systems from NanoSight and their technology, Nanoparticle Tracking Analysis.
Fabrication and Thermal Conductivity of Boron Carbide/Copper Cermet (1999)

Studies on fabrication and thermal conductivity of B4C/Cu cermet were made to obtain high performance neutron absorber materials for Liquid Metal-cooled Fast Breeder Reactor (LMFBR). A mixed powder of B4C and Cu was mechanically blended at high speed thereby a coating layer of Cu was formed on the surface of B4C powder. Then the B4C powder with Cu coating was hot pressed at temperatures from 950 to 1,050°C to form a B4C cermet. A high density B4C/CU cermet with 70 vol% of B4C and relative density higher than 90% was successfully fabricated. In spite of the low volume fraction of Cu. the B4C/Cu cermet exhibited high thermal conductivity which originated from the existence of continuous metallic phase Cu in B4C/Cu cermet.
Segment‐averaged LET concept and analytical calculation from microdosimetric quantities in proton radiation therapy (2019)

A new way of averaging LET for a proton beam is performed to incorporate the effects produced by the variation of stopping power of each individual proton along microscopic biological structures. An analytical model based on MC simulations allows for fast and accurate calculations of segment-averaged dose-averaged restricted LET for proton beams, which otherwise would need to be calculated from exhaustive MC simulations of clinical plans.
Homoisoflavonoids and related compounds. III. Phenolic constituents of Caesalpinia japonica Sieb. et Zucc. (1987)

A new homoisoflavonoid, 3'-deoxy-4-O-methylsappanol (3, 7-dihydroxy-3- (4-hydroxybenzyl) 4-methoxychroman) was isolated from the wood of Caesalpinia japonica SIEB. et Zucc. (Leguminosae), together with the known compounds, sappanol, episappanol, 4-O-methylsappanol, 4-O-methylepisappanol, sappanones A and B, sappanchalcone, 3-deoxysappanchalcone, isoliquiritigenin, butein, brazilin and protosappanins A, B and C. None of these compounds has previously been isolated from this plant.
Colorful Textile Antennas Integrated into Embroidered Logos (2015)

We present a new methodology to create colorful textile antennas that can be embroidered within logos or other aesthetic shapes. Conductive threads (e-threads) have already been used in former embroidery unicolor approaches as attributed to the corresponding conductive material, viz. silver or copper. But so far, they have not been adapted to ‘print’ colorful textile antennas. For the first time, we propose an approach to create colorful electronic textile shapes. In brief, the embroidery process uses an e-thread in the bobbin case of the sewing machine to embroider the antenna on the back side of the garment. Concurrently, a colorful assistant yarn is threaded through the embroidery needle of the embroidery machine and used to secure or ‘couch’ the e-threads onto the fabric. In doing so, a colorful shape is generated on the front side of the garment. The proposed antennas can be unobtrusively integrated into clothing or other accessories for a wide range of applications (e.g., wireless communications, Radio Frequency IDentification, sensing).
Grasping polyhedral objects with slip (2003)

A force strategy developed by R.S. Fearing (1986) for automatically grasping two-dimensional polygon objects by a dextrous hand with point contact with friction is shown to be applicable to three-dimensional polyhedral objects. The algorithm essentially consists of position control of one finger and force control of the other along the internal force directions. Basic geometric constraints on the object are obtained for feasible grasping with two fingers. It is observed that, when an object is rotated about the line passing through soft finger contacts, the fingers slip on the object in a simple predictable trajectory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Harmonic generation in multiresonant plasma films (2013)

We investigate second- and third-harmonic generation in a slab of material that displays plasma resonances at the pump and its harmonic frequencies. Near-zero refractive indices and local field enhancement can deplete the pump for kW/cm${}^{2}$ incident powers, without resorting to other resonant photonic mechanisms. We show that low-threshold, highly efficient nonlinear processes are possible in the presence of losses and phase mismatch in structures that are 10${}^{4}$ times shorter than typical nonlinear crystals, for relatively low irradiance values.
Kinetic Analysis of Phospholipase C βIsoforms Using Phospholipid-Detergent Mixed Micelles (1995)

Phosphatidylinositol 4,5-bisphosphate (PtdIns (4,5)-P2) hydrolysis by three different beta-isoforms of phospholipase C (PLC) was examined to investigate the catalytic action of these extracellular signal-regulated enzymes. Depletion of phospholipase C from solution by incubation with sucrose-loaded vesicles of differing compositions followed by ultracentrifugation demonstrated stable attachment of PLC to the vesicles from which an equilibrium association constant of PLC with PtdIns (4,5)P2 could be determined. A mixed micellar system was established to assay PLC activity using dodecyl maltoside, which behaved as an essentially inert diluent of PtdIns (4,5)P2 with respect to PLC beta activity. Kinetic analyses were performed to test whether PLC beta activity was dependent on both bulk PtdIns (4,5)P2 concentration and surface concentration in the micelles as has been shown for other lipid metabolising enzymes. Each of the PLC beta isoforms behaved similarly in these analyses, which indicated the involvement of at least two binding events. Interfacial Michaelis constants were calculated to be between 0.1-0.2 mol fraction for all three enzymes, and Ks (the equilibrium dissociation constant of PLC for lipid) ranged between 100-200 microM. The apparent multiple interfacial binding events did not appear to result from lipid-induced PLC beta oligomerization implying that PLC beta monomers possess more than one lipid-binding site. Surface dilution of PLC-catalyzed PtdIns (4,5)P2 hydrolysis was assessed in the presence of increasing concentrations of various nonsubstrate phospholipids, which profoundly reduced PLC activity, suggesting that these lipids may inhibit enzyme action. The data indicate that G protein-regulated isoforms of PLC operate with separate lipid binding and catalytic steps and imply that under physiological conditions, PLC beta isoforms operate under first-order conditions. These findings may have implications for the mechanisms of regulation of PLC beta s by G protein subunits.