gebhart/patrepeval huggingface dataset:
Pharmacokinetics, Clinical Efficacy and Safety of Plasma-Derived Nanofiltered C1 Inhibitor Concentrate for Treatment of Hereditary and Acquired Angioedema. (2008)

Abstract RATIONALE: From the early 70’s, C1 inhibitor concentrate manufactured from pooled human plasma has been available to patients with hereditary and acquired angioedema (HAE and AAE) and in 1997 a highly purified C1 inhibitor (Cetor®) was introduced. Many precautions have been taken to minimize the potential risk of viral transmission (e.g. rigorously controlled whole blood collection systems, extensive screening of each individual donation for a variety of blood-borne viruses, pasteurisation). To further minimize the potential risk of viral transmission, a 15 nm filtration was implemented in the manufacturing process giving rise to C1-inhibitor-N (anofiltered). DESIGN: A randomised, double-blind, controlled cross-over phase II study was conducted in which our primary objective was to compare the pharmacokinetics of the newly developed concentrate with conventional C1-inhibitor concentrate in HAE patients without signs of an attack of angioedema. Secondly, an open-label phase III study in patients with an HAE attack was performed to investigate whether the introduction of the virus reducing 15nm filtration step in the manufacturing process of the concentrate did not affect the efficacy and safety of the product. RESULTS: Thirteen patients were enrolled in the phase II study. No differences between conventional C1-inhibitor concentrate and nanofiltered C1-inhibitor concentrate were detected with regard to the primary pharmacokinetic parameters clearance, volume of distribution, and the fraction of C1-inhibitor-N detected by the antigen assay relative to the functional assay. Therefore incremental recovery, mean residence time, half-life and the area under curve were equivalent for both products. In the phase III study, 8 HAE patients were enrolled. In these 8 patients, 14 attacks qualified as acute angioedema attack. The mean time-to-relief for attacks treated with new C1-inhibitor concentrate was 3.0 (SD 2.5) hours. Historical data showed that treatment with conventional C1-inhibitor concentrate resulted in time-to-relief of 3.9 (SD 6.2) hours, whereas for untreated attacks this was 24.7 (SD 19.9) hours. The attacks treated with new C1-esterase inhibitor concentrate had a mean time-to-resolve of 18.6 hours (SD 13.1) whereas medical history showed an time-to-resolve of 17.8 hours (SD 17.2) for conventional C1-inhibitor. Untreated attacks showed a mean time-to-resolve of 63.6 hours (SD 31.0). CONCLUSION: The newly developed nanofiltered C1-esterase inhibitor has equal pharmacokinetic properties compared to the conventional concentrate. The viral reduction step (15 nm filtration) in the production process of Cetor did not induce changes in the efficacy and safety in the treatment of acute angioedema attacks and in the pharmacokinetic parameters.
Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs (2018)

Oxidative and electrophilic changes in cells are mainly coordinated by the KEAP1/NRF2 (Kelch-like erythroid-derived cap-n-collar homology- (ECH-) associated protein-1/nuclear factor (erythroid-derived 2)-like 2) axis. The physical interaction between these two proteins promotes the expression of several antioxidant defense genes in response to exogenous and endogenous insults. Recent studies demonstrated that KEAP1/NRF2 axis dysfunction is also strongly related to tumor progression and chemo- and radiotherapy resistance of cancer cells. In solid tumors, the KEAP1/NRF2 system is constitutively activated by the loss of <i>KEAP1</i> or gain of <i>NFE2L2</i> functions that leads to its nuclear accumulation and enhances the transcription of many cytoprotective genes. In addition to point mutations, epigenetic abnormalities, as aberrant promoter methylation, and microRNA (miRNA) and long noncoding RNA (lncRNA) deregulation were reported as emerging mechanisms of KEAP1/NRF2 axis modulation. This review will summarize the current knowledge about the epigenetic mechanisms that deregulate the KEAP1/NRF2 cascade in solid tumors and their potential usefulness as prognostic and predictive molecular markers.
Rhizobium meliloti nodulation genes: identification of nodDABC gene products, purification of nodA protein, and expression of nodA in Rhizobium meliloti (1985)

A set of conserved, or common, bacterial nodulation (nod) loci is required for host plant infection by Rhizobium meliloti and other Rhizobium species. Four such genes, nodDABC, have been indicated in R. meliloti 1021 by genetic analysis and DNA sequencing. An essential step toward understanding the function of these genes is to characterize their protein products. We used in vitro and maxicell Escherichia coli expression systems, together with gel electrophoresis and autoradiography, to detect proteins encoded by nodDABC. We facilitated expression of genes on these DNA fragments by inserting them downstream of the Salmonella typhimurium trp promoter, both in colE1 and incP plasmid-based vectors. Use of the incP trp promoter plasmid allowed overexpression of a nodABC gene fragment in R. meliloti. We found that nodA encodes a protein of 21 kilodaltons (kDa), and nodB encodes one of 28 kDa; the nodC product appears as two polypeptide bands at 44 and 45 kDa. Expression of the divergently read nodD yields a single polypeptide of 33 kDa. Whether these represent true Rhizobium gene products must be demonstrated by correlating these proteins with genetically defined Rhizobium loci. We purified the 21-kDa putative nodA protein product by gel electrophoresis, selective precipitation, and ion-exchange chromatography and generated antiserum to the purified gene product. This permitted the immunological demonstration that the 21-kDa protein is present in wild-type cells and in nodB- or nodC-defective strains, but is absent from nodA::Tn5 mutants, which confirms that the product expressed in E. coli is identical to that produced by R. meliloti nodA. Using antisera detection, we found that the level of nodA protein is increased by exposure of R. meliloti cells to plant exudate, indicating regulation of the bacterial nod genes by the plant host.
Characterization of the bovine herpesvirus 1 UL8 gene and gene products. (1998)

The bovine herpesvirus 1 (BHV-1) strain Schönböken UL8 gene and the 5' flanking region were sequenced. Comparison of the UL8 ORF with the previously reported UL8 ORF of BHV-1 strain Cooper revealed significant differences that were mainly due to three frame-shifted segments. Reanalysis of the Cooper sequence after isolation of the respective segments from genomic DNA by PCR did not confirm the discrepancies; on the contrary, our results indicate a high degree of sequence conservation between the UL8 proteins of different BHV-1 isolates. A monospecific antiserum, raised against a bacterially expressed TrpE-UL8 fusion protein, identified the 80 kDa apparent molecular mass UL8 polypeptide which is localized in the nucleus of infected cells. Analysis of transcripts and time-course studies demonstrated that the UL8 protein is translated from a delayed-early expressed 3.1 kb polyadenylated mRNA which initiates within the UL9 ORF.
Estrogen receptor and progesterone receptor genes are expressed differentially in mouse embryos during preimplantation development. (1993)

Estrogen and progesterone play an important role in the development and implantation of preimplantation embryos. However, it is controversial whether these hormones act directly on the embryos. The effects of these hormones depend on the existence of their specific receptors. To determine whether estrogen receptor (ER) and progesterone receptor genes are expressed in mouse preimplantation embryos, we examined RNA from embryos at different stages of preimplantation development by reverse transcription-polymerase chain reaction techniques. ER mRNA was found in oocytes and fertilized eggs. The message level began to decline at the two-cell stage and reached its lowest level at the five- to eight-cell stage. ER mRNA was not detectable at the morula stage but reappeared at the blastocyst stage. Progesterone receptor mRNA was not detectable until the blastocyst stage. The embryonic expression of ER and progesterone receptor genes in the blastocyst suggests a possible functional requirement for ER and progesterone receptor at this stage of development. These results provide a basis for determining the direct role of estrogen and progesterone in preimplantation embryos.
The Advent of Dynamic Graphics Statistical Computing (1993)

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The expression of growth hormone-releasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas (2002)

Splice variants (SVs) of receptors for growth hormone-releasing hormone (GHRH) have been found in primary human prostate cancers and diverse human cancer cell lines. GHRH antagonists inhibit growth of various experimental human cancers, including pancreatic and colorectal, xenografted into nude mice or cultured in vitro, and their antiproliferative action could be mediated in part through SVs of GHRH receptors. In this study we examined the expression of mRNA for GHRH and for SVs of its receptors in tumors of human pancreatic, colorectal, and gastric cancer cell lines grown in nude mice. mRNA for both GHRH and SV(1) isoform of GHRH receptors was expressed in tumors of pancreatic (SW1990, PANC-1, MIA PaCa-2, Capan-1, Capan-2, and CFPAC1), colonic (COLO 320DM and HT-29), and gastric (NCI-N87, HS746T, and AGS) cancer cell lines; mRNA for SV(2) was also present in Capan-1, Capan-2, CFPAC1, HT-29, and NCI-N87 tumors. In proliferation studies in vitro, the growth of pancreatic, colonic, and gastric cancer cells was stimulated by GHRH(1-29)NH(2) and inhibited by GHRH antagonist JV-1-38. The stimulation of some gastroenteropancreatic cancer cells by GHRH was followed by an increase in cAMP production, and GHRH antagonist JV-1-38 competitively inhibited this effect. Our study indicates the presence of an autocrine/paracrine stimulatory loop based on GHRH and SV(1) of GHRH receptors in human pancreatic, colorectal, and gastric cancers. The finding of SV(1) receptor in human cancers provides an approach to an antitumor therapy based on the blockade of this receptor by specific GHRH antagonists.
Directed Amination of Non‐Acidic Arene CH Bonds by a Copper–Silver Catalytic System (2013)

Amine meets arene: A method for direct amination of β-C(sp(2))-H bonds of benzoic acid derivatives and γ-C(sp(2))-H bonds of benzylamine derivatives has been developed. The reaction is catalyzed by Cu(OAc)2 and a Ag2CO3 cocatalyst, and shows high generality and functional-group tolerance, as well as providing a straightforward means for the preparation of ortho-aminobenzoic acid derivatives.
KAJIAN NILAI PANCASILA DALAM TRADISI SENGUYUN MASYARAKAT DAYAK KENYA DI DESA SAJAU KECAMATAN TANJUNG PALAS TIMUR (2020)

Rendahnya kesadaran dan kepedulian masyarakat terhadap Pancasila dan diikuti tidak adanya pengamalan Pancasila ke dalam kehidupan sehari-hari. Melemahnya sikap sosialis dan meningkatnya sikap individualis, melemahnya pemahaman masyarakat tentang nilai-nilai Pancasila dan menguatnya pemahaman radikalis, pembangunan berorientasi jangka pendek (pragmatis) dan partisipasi masyarakat tanpa pola serta kering dari spirit moralitas. Dalam jangka panjang kondisi ini dapat memperlemah pilar-pilar kehidupan berbangsa dan bernegara. Tujuan penelitian ini adalah untuk mengidentifikasi nilai-nilai Pancasila yang terdapat dalam tradisi dan nilai-nilai yang memperkuat kehidupan berbangsa dan bernegara melalui tradisi Senguyun masyarakat Dayak Kenya. Penelitian ini menggunakan metode kualitatif yang bermaksud untuk memahami dan mendeskripsikan fenomena tentang apa yang dialami oleh subjek penelitian secara holistik. Data berasal dari data primer dan sekunder yang diperoleh dari observasi, wawancara dan dokumentasi masyarakat dalam tradisi senguyun. Hasil penelitian ini menemukan bahwa nilai – nilai Pancasila terdapat dalam tradisi Senguyun.
The ATAC trial: the vanguard trial for use of aromatase inhibitors in early breast cancer (2007)

The Anastrozole, Tamoxifen, Alone or in Combination (ATAC) trial was the first trial to explore the use of aromatase inhibitors in post-menopausal women with early breast cancer and is the largest published cancer treatment trial in breast cancer. The main results have been published at 33-, 47- and 68-month median follow-up, and further analyses are planned for the end of 2007 and in 2010. This trial demonstrated that 5 years of treatment with anastrozole was generally better tolerated than 5 years of treatment with tamoxifen, and led to lower recurrence rates, especially in receptor-positive women (26% reduction). The side-effect profile was different than that for tamoxifen, with fewer hot flushes, gynecologic symptoms, endometrial cancers, strokes and thromboembolic events; however, an increased incidence of fractures, joint symptoms and carpal tunnel syndrome was observed. Future analyses will determine whether benefits and fracture rates persist after stopping treatment, and the extent to which currently marginal benefits on late end points, such as distant recurrence and death after recurrence, are sustained or improved.
Extended virtual synchrony (2002)

We formulate a model of extended virtual synchrony that defines a group communication transport service for multicast and broadcast communication in a distributed system. The model extends the virtual synchrony model of the Isis system to support continued operation in all components of a partitioned network. The significance of extended virtual synchrony is that, during network partitioning and remerging and during process failure and recovery, it maintains a consistent relationship between the delivery of messages and the delivery of configuration changes across all processes in the system and provides well-defined self-delivery and failure atomicity properties. We describe an algorithm that implements extended virtual synchrony and construct a filter that reduces extended virtual synchrony to virtual synchrony.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A comparison between Pc 3–4 pulsations observed by GOES 7 and the CANOPUS magnetometer array (1997)

We have analyzed 1 month of GOES 7 and Canadian Auroral Network for the OPEN Program Unified Study (CANOPUS) magnetometer data and compared Pc 3–4 wave activity seen at geosynchronous orbit with simultaneous ground Pc 3–4 pulsations at auroral latitudes. We found that at geosynchronous orbit the majority of coherent Pc 3–4 events were azimuthally or radially polarized. A number of transverse events revealed clear field line resonance (FLR) signatures in the latitudinal power, polarization, and phase variations. However, the FLR characteristics often appeared to be masked by ionospheric screening and/or wave propagation effects. The azimuthal phase propagation was found to be antisunward for most events, although sunward phase propagation has also been observed. The ground Pc 3–4 occurrence, polarization, and longitudinal phase characteristics associated with transverse waves were found to be similar to those of auroral latitude Pc 5 pulsations. These similarities between transverse Pc 3–4 and auroral latitude Pc 5 characteristics may point to a common source mechanism for these pulsations. One event appeared consistent with the excitation of multiple waveguide modes. Most compressional Pc 3–4 activity appeared to be relatively broadband and virtually unpolarized. However, the center frequency of the dominant band was found to be well correlated with the interplanetary magnetic field magnitude. Power spectra from the ground stations usually contained significant signal power within the frequency band of the compressional perturbation seen by GOES 7. It is shown that at some frequencies, the broadband compressional waves may excite local field line resonances, whereas at other frequencies the compressional signal is transmitted to the ground without obvious resonance structures. The ground Pc 3–4 occurrence, spectral, polarization, and longitudinal phase characteristics associated with compressional waves were found to differ in several respects from the signal characteristics associated with transverse waves. These differences between transverse and compressional Pc 3–4 waves argue against upstream waves being the sole source of auroral latitude Pc 3–4 pulsations.
New ESIPT-Inspired Photostabilizers of Two-Photon Absorption Coumarin–Benzotriazole Dyads: From Experiments to Molecular Modeling (2016)

In this work, a variety of new coumarin–benzotriazole dyads are synthesized to study the photostabilities under the irradiation of broad UV light as well as near-infrared (near-IR) laser respectively inspired by efficient excited state intramolecular proton transfer (ESIPT). The corresponding esterified dyads and the coumarin dyes are prepared as the references. The intramolecular hydrogen bond in the target dyads is confirmed by 1H NMR spectra and UV/visible absorption spectra. The internal proton transfer in the excited states of the target dyads under single photon excitation and near-IR laser irradiation is demonstrated by the measurements of one-photon fluorescence spectra and two-photon upconverted fluorescence spectra, respectively. The photostabilities of the target dyads under broad UV light irradiation and near-IR laser irradiation in various organic solvents with saturated air, oxygen, or argon are studied. The theoretical evidence of ESIPT of the target dyads is provided by the molecular geometry optimization of enol, keto, and transition-state forms in the ground and excited states as well as the potential energy curves of enol–keto phototautomerization.
Microorganism as Plastic Biodegradation Agent towards Sustainable Environment (2015)

The usage of plastic is critically in demand due to its character which can be shaped into almost any desired shape and its ability to retain that shape. Unfortunately, the wastage of those plastics leads to many environmental issues and hazards towards human health. Basically, plastics can degrade in the environment through four mechanisms which are photodegradation, thermooxidative, hydrolytic degradation and microbial degradation. Microbial degradation is subject to microorganism which acts as biodegradation agent. In this case, microorganism will secrete an active enzyme to break down long chain polymers. Microbial enzymes are attractive because the cost to grow and maintain them is less and they are easy to manipulate. Rhizopus delemar , Rhizophus arrizus and Pseudomonas sp. were among the most cited bacteria that have successfully degraded certain type of plastics. Whereas, fungal species of Aspergillus flavus and Penicillium funiculosum were recorded by scientist which react with certain plastic’s substrate. The objective of this paper is to review several species of microorganism that have been experimented by scientist and were claimed to have the capability to degrade plastic towards eco-friendly approaches in order to sustain our environment. In conclusion, microorganisms are very effective agent to fasten degradation process of plastics without causing any side effect like chemical or synthetic method does.
Normal erythrocyte sedimentation rate in the elderly. (1984)

Two hundred subjects aged 60-89 were selected for a study aimed at defining a reference range for the erythrocyte sedimentation rate in the elderly. The study extended a previous survey in subjects aged 20-65. The results confirmed that the sedimentation rate increases with age and that women have higher values than men but suggested that over half of elderly patients with disease would have rates within the previously defined "normal" range. It is therefore suggested that an erythrocyte sedimentation rate exceeding 19 mm in the first hour in elderly men and 22 mm in the first hour in elderly women warrants investigation.
[Recensione a]: Mario Caramitti, «Letteratura russa contemporanea. La scrittura come resistenza», Bari, Laterza, 2010 (2011)

Estesa recensione allo studio attualmente più completo sulla letteratura russa degli ultimi 40 anni circa
Properties of the Electric Double Layer Capacitors Composed of Activated Carbon Fiber Cloth Electrodes and a Organic Electrolyte (1988)

Prperiesfheelecricdublelayer capac rs cmpsedfthreetypesQfacivaedcarbnfiber cloths ACFCs) ie phenolic based ACFC rayon based ACFC and polyacryonitrile based ACFC (PAN based CPC as polarizable electrodes have been invesigaed The specific surface area and he poe size dstrbuton of he ACFCs depended both onheix raw materia15 and on he activation methods The specifc suface area of PAN based ACFC rayon base4 0ne and phenolic based one increa5ed in tha order The elecric double laye capacitance at25C ws proportiona to the specific surface area Qf the ACFC pol aiz able electrQde The Performance ofi the capaciors was influenced by the poe size distrbuion of he ACFCs The internal resstance Qf he capaciors was grealy influenced by he conductiviy Of he Qrganic electrolye espeoially at a low temperatue250Cl 1NTRODUCTON
A Modified Method for the Meerwein-Ponndorf-Verley Reduction (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Modified Method for the Meerwein-Ponndorf-Verley ReductionW. L. Truett and W. N. MoultonCite this: J. Am. Chem. Soc. 1951, 73, 12, 5913–5914Publication Date (Print):December 1, 1951Publication History Published online1 May 2002Published inissue 1 December 1951https://pubs.acs.org/doi/10.1021/ja01156a558https://doi.org/10.1021/ja01156a558research-articleACS PublicationsRequest reuse permissionsArticle Views313Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Association of Recall Rates with Sensitivity and Positive Predictive Values of Screening Mammography (2001)

Practices with recall rates between 4.9% and 5.5% achieve the best trade-off of sensitivity and positive predictive value.