gebhart/patrepeval huggingface dataset:
STRUCTURE NONLINEARITY AND RESPONSE OF LATERALLY LOADED PILES (2011)

In light of a generic limiting force profile (LFP), closed·form solutions for laterally loaded free- and fixed- head piles in elastic-plastic media have been developed, and implemented by the first author into a spreadsheet program called GASLFP. The solutions offer an expeditious and sufficiently accurate prediction of response of lateral piles. Conversely, they allow input parameters to be deduced using measured pile response, as has been conducted for over 70 test (elastic) piles to date. Nevertheless. structure nonlinearity of pile body is an important issue at a large deflection. In this paper, a semi·empirical approach is established to capture pile response owing to structural nonlinearity. Expressions were provided for gaining cracking moment Mcr, flexural rigidity of cracked cross section Eplp. and ultimate bending moment Mult Against measured response of two laterally loaded single piles, back-estimation indicates that (1) the parameters for elastic piles are quite consistent with the previous findings for piles in sand and clay, (2) The proposed variations of Mcr, Eplp and Mult, for nonlinear piles provide good prediction of the pile response against measured data and (3) the modulus of rupture kr of 16.7 (clay) and 33.0(sand) are close 10 those adopted for structural beams, although a very high kr of 62.7 (thus resulting in higher Mcr, ) for a pi le in sand was deduced (shown elsewhere). The use of the kr for beams would render pile deflections of the later pile to be significantly overestimated. The conclusions may be incorporated into design of laterally loaded piles.
Coordination chemistry of pyrazole-derived ligands (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoordination chemistry of pyrazole-derived ligandsSwiatoslaw. TrofimenkoCite this: Chem. Rev. 1972, 72, 5, 497–509Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://pubs.acs.org/doi/10.1021/cr60279a003https://doi.org/10.1021/cr60279a003research-articleACS PublicationsRequest reuse permissionsArticle Views4345Altmetric-Citations618LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biomaterials in Craniofacial Surgery (2009)

The increasing variety of biomaterials available to the craniofacial surgeon today, with advantages of "off-the-shelf availability" and lack of donor-site morbidity, provides a formidable armamentarium for applications in reconstruction and augmentation. Although biomaterials are invaluable alternatives to autogenous bone graft, there is lack of uniformity in clinical application. In this article, we review our experience with the use of hydroxyapatite derivatives in animal studies and subsequently discuss our experience with the use of 3 classes of biomaterials (cement pastes, osteoactive biomaterials, and prefabricated polymers) for craniofacial reconstruction. We subsequently offer guidelines to dictate the choice of biomaterials for different applications, based on the site of reconstruction (onlay versus inlay reconstruction) and skeletal maturity.
Reaction of C<sub>60</sub> with Dimethyldioxirane—Formation of an Epoxide and a 1,3‐Dioxolane Derivative (1992)

Not an oxygen-bridged annulene (structural type 1) but rather an epoxide (structural type 2) is the product of the reaction of dimethyldioxirane with C60. In a competing reaction, a 1,3-dioxolane (structural type 3) is formed—probably by a diradical mechanism. Cleavage of acetone from 3 leading to 2 was not observed at temperatures up to 110°C. Compound 3 could provide access to ring-opened fullerenes.
Coherent Control of High Harmonic Generation via Dual-Gas Multijet Arrays (2011)

High harmonic generation (HHG) is a central driver of the rapidly growing field of ultrafast science. We present a novel quasiphase-matching (QPM) concept with a dual-gas multijet target leading, for the first time, to remarkable phase control between multiple HHG sources (>2) within the Rayleigh range. The alternating jet structure with driving and matching zones shows perfect coherent buildup for up to six QPM periods. Although not in the focus of the proof-of-principle studies presented here, we achieved competitive conversion efficiencies already in this early stage of development.
Pairwise coupled hybrid vanadium dioxide-MOSFET (HVFET) oscillators for non-boolean associative computing (2014)

Information processing applications related to associative computing like image/pattern recognition consume excessive computational resources in the Boolean processing framework. This motivates the exploration of a non-Boolean computing approach for such applications. In this work, we demonstrate: (i) novel hybrid set of pair-wise coupled oscillators comprising of vanadium dioxide (VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) metal-insulator-transition (MIT) system integrated with MOSFET; (ii) degree of synchronization between oscillators based on input analog voltage difference; (iii) implementation of hardware platform for fast and efficient evaluation of L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</sub> fractional distance norm (k<;1); (iv) improved quality of image processing and ~20X lower power consumption of the coupled oscillators over a CMOS accelerator.
SOLUBILITIES OF HIGH MOLECULAR WEIGHT NORMAL ALIPHATIC PRIMARY AMINES (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSOLUBILITIES OF HIGH MOLECULAR WEIGHT NORMAL ALIPHATIC PRIMARY AMINESA. W. RALSTON, C. W. HOERR, W. O. POOL, and H. J. HARWOODCite this: J. Org. Chem. 1944, 09, 1, 102–112Publication Date (Print):January 1, 1944Publication History Published online1 May 2002Published inissue 1 January 1944https://pubs.acs.org/doi/10.1021/jo01183a012https://doi.org/10.1021/jo01183a012research-articleACS PublicationsRequest reuse permissionsArticle Views399Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bindings of PPAR<sub>γ</sub> ligand-binding domain with 5-cholesten-3β, 25-diol, 3-sulfate: accurate prediction by molecular simulation (2019)

Peroxisome proliferator-activated receptor gamma (PPAR<sub>γ</sub>) has recently been identified as an attractive target for atherosclerosis intervention. Given potential relevance of 5-cholesten-3β, 25-diol, 3-sulphate (CHOS) and PPAR<sub>γ</sub>, an integrated docking method was used to study their interaction mechanisms, with the full considerations to distinct CHOS conformations and dynamic ensembles of PPAR<sub>γ</sub> ligand-binding domain (PPAR<sub>γ</sub>-LBD). The results revealed that this novel platform is satisfactory to the accurate determination of binding profiles, and the binding pattern of CHOS is rather similar as those of current PPAR<sub>γ</sub> full/partial agonists. CHOS contributes to the stabilization of the AF2 and β-sheet surfaces of PPAR<sub>γ</sub>-LBD and promotes the configuration adjustment of Ω loop, in order to inhibit the Cdk5-mediated PPAR<sub>γ</sub> phosphorylation. Nonetheless, there are clear differences in term of occupation of full or partial agonist-like binding models. The energetic and geometric analyses further revealed that CHOS may be fond of partial agonist-like binding, and its sulfonic group and carbon skeleton are helpful for the binding process. We hope that the results will aid our understanding of recognitions involving CHOS with PPAR<sub>γ</sub>-LBD and warrant the further aspects to pharmacological experiments.Communicated by Ramaswamy H. Sarma.
A Technique for Digital Information Broadcasting Using SCA Channels (1981)

This paper describes a simple technique using the SCA (Subsidiary Communications Authorization) channel authorized for use in FM and TV broadcasting to provide a one-way digital transmission channel for teletext-type service. The channel is transparent to data format. Preliminary field test results for a 9600 bit/second channel are also presented which show average error rates of less than 1 in 106.
A Controlled Trial of Combined Therapy for Newly Diagnosed Severe Childhood IgA Nephropathy (1999)

The most appropriate treatment for patients with IgA nephropathy is controversial. Treatment with prednisolone, azathioprine, heparin-warfarin, and dipyridamole early in the course of disease may prevent immunologic renal injury in children with severe IgA nephropathy. To determine whether similar results can be obtained with a combination of just heparin-warfarin and dipyridamole, the effects of such treatment were compared to those of treatment with prednisolone, azathioprine, heparin-warfarin, and dipyridamole in 78 children with newly diagnosed IgA nephropathy showing diffuse mesangial proliferation. The patients were randomly assigned to receive either prednisolone, azathioprine, heparin-warfarin, and dipyridamole for 2 yr (group 1) or heparin-warfarin and dipyridamole for 2 yr (group 2). All of the 40 patients in group 1 and 34 of the 38 patients in group 2 completed the trial. The mean urinary protein excretion fell in group 1 patients (P < 0.0001), but remained unchanged in group 2 patients. The mean serum IgA concentration was reduced in group 1 patients (P = 0.0002), but was unchanged in group 2 patients. BP and creatinine clearance were normal at the end of the trial in all but one group 2 patient, who developed chronic renal insufficiency. The percentage of glomeruli showing sclerosis was unchanged in group 1 patients, but increased in group 2 patients (P = 0.006). The intensity of mesangial IgA deposits decreased in group 1 patients (P = 0.02), but remained unchanged in group 2 patients. In conclusion, the present study shows that treatment of children with severe IgA nephropathy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for 2 yr early in the course of disease reduces immunologic renal injury and prevents increase of sclerosed glomeruli.
Design of a 2D MEMS micromirror with indirect static actuation (2017)

We present the design of a 2D MEMS micromirror with indirect static actuation based on gyroscopic effects. Additionally to the primary resonant oscillation we introduce a second one, disturbing the angular momentum of the former. This under special conditions leads to a directed torque about a third axis. This concept thus uses only resonant actuation by still enabling static deflection, potentially being more energy efficient compared to current technologies. After discussion of the used manufacturing process, the MEMS design workflow and the resulting fully functional micromirror design is shown. In first experimental results we then show a proof of concept for the manufactured micromirror devices.
Massively-Parallel Neuromonitoring and Neurostimulation Rodent Headset With Nanotextured Flexible Microelectrodes (2013)

We present a compact wireless headset for simultaneous multi-site neuromonitoring and neurostimulation in the rodent brain. The system comprises flexible-shaft microelectrodes, neural amplifiers, neurostimulators, a digital time-division multiplexer (TDM), a micro-controller and a ZigBee wireless transceiver. The system is built by parallelizing up to four 0.35 μm CMOS integrated circuits (each having 256 neural amplifiers and 64 neurostimulators) to provide a total maximum of 1024 neural amplifiers and 256 neurostimulators. Each bipolar neural amplifier features 54 dB-72 dB adjustable gain, 1 Hz-5 kHz adjustable bandwidth with an input-referred noise of 7.99 μVrms and dissipates 12.9 μW. Each current-mode bipolar neurostimulator generates programmable arbitrary-waveform biphasic current in the range of 20-250 μA and dissipates 2.6 μW in the stand-by mode. Reconfigurability is provided by stacking a set of dedicated mini-PCBs that share a common signaling bus within as small as 22 × 30 × 15 mm³ volume. The system features flexible polyimide-based microelectrode array design that is not brittle and increases pad packing density. Pad nanotexturing by electrodeposition reduces the electrode-tissue interface impedance from an average of 2 MΩ to 30 kΩ at 100 Hz. The rodent headset and the microelectrode array have been experimentally validated in vivo in freely moving rats for two months. We demonstrate 92.8 percent seizure rate reduction by responsive neurostimulation in an acute epilepsy rat model.
Asymptotic Distributions of the Least Squares Estimator for Diffusion Processes (2010)

The asymptotic distributions of the least squares estimator of the mean reversion parameter (κ) are developed in a general class of diffusion models under three sampling schemes, namely, long-span, in-fill and the combination of long-span and in-fill. The models have an affine structure in the drift function, but allow for nonlinearity in the diffusion function. The limiting distributions are quite different under the alternative sampling schemes. In particular, the in-fill limiting distribution is non-standard and depends on the initial condition and the time span whereas the other two are Gaussian. Moreover, while the other two distributions are discontinuous at κ = 0, the in-fill distribution is continuous in κ. This property provides an answer to the Bayesian criticism to the unit root asymptotics. Monte Carlo simulations suggest that the in-fill asymptotic distribution provides a more accurate approximation to the finite sample distribution than the other two distributions in empirically realistic settings. The empirical application using the U.S. Federal fund rates highlights the difference in statistical inference based on the alternative asymptotic distributions and suggests strong evidence of a unit root in the data.
Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses (2012)

Tumor-infiltrating immune cells can promote chemoresistance and metastatic spread in aggressive tumors. Consequently, the type and quality of immune responses present in the neoplastic stroma are highly predictive of patient outcome in several cancer types. In addition to host immune responses, intrinsic tumor cell activities that mimic stem cell properties have been linked to chemoresistance, metastatic dissemination, and the induction of immune suppression. Cancer stem cells are far from a static cell population; rather, their presence seems to be controlled by highly dynamic processes that are dependent on cues from the tumor stroma. However, the impact immune responses have on tumor stem cell differentiation or expansion is not well understood. In this study, we show that targeting tumor-infiltrating macrophages (TAM) and inflammatory monocytes by inhibiting either the myeloid cell receptors colony-stimulating factor-1 receptor (CSF1R) or chemokine (C-C motif) receptor 2 (CCR2) decreases the number of tumor-initiating cells (TIC) in pancreatic tumors. Targeting CCR2 or CSF1R improves chemotherapeutic efficacy, inhibits metastasis, and increases antitumor T-cell responses. Tumor-educated macrophages also directly enhanced the tumor-initiating capacity of pancreatic tumor cells by activating the transcription factor STAT3, thereby facilitating macrophage-mediated suppression of CD8(+) T lymphocytes. Together, our findings show how targeting TAMs can effectively overcome therapeutic resistance mediated by TICs.
Temperature measurement in microfluidic chips using photobleaching of a fluorescent thin film (2008)

A method for the whole chip temperature measurement is developed and presented here. This method includes two major contributions: (i) a specially developed measurement model illustrating the relationship between the photobleaching speed of a fluorescent dye and its temperature and (ii) an introduction of a thin polydimethylsiloxane film with rhodamine B homogeneously saturated aiming for significantly reducing fluorescent dyes’ absorption to and diffusion into polymer-made channel walls. The developed method is validated by comparing the experimentally measured temperature distribution in a microfluidic chip with the numerically predicted results.
Atropine Depression of Food and Water Intake in the Rat (1958)

The effect of atropine upon food and water intake was investigated in the albino rat. Dosages up to approximately 7 mg/kg of atropine sulfate were used in two experiments upon water intake and an experiment upon food intake. Atropine depressed both food and water intake to some limiting value. Eating was reduced to a greater extent than was drinking relative to the control conditions. The experimental arrangements obviated the possibility that the depression of water intake, by atropine, is contingent upon reduced food intake, while the procedure used for studying food intake did not exclude the possibility of the observed reduction of eating being dependent upon reduced drinking. However, the relatively greater reduction of eating as compared with drinking suggests that such a dependency will not account for the total effect.
Time multiplexed optical shutter (TMOS) display technology for avionics platforms (2006)

Time Multiplexed Optical Shutter (TMOS) is a new approach to flat panel light valve display technology that addresses display requirements in avionics applications, particularly head-down cockpit deployments. TMOS modulates the local transmission of light from a waveguide coextensive with the screen. The architecture requires fewer, larger on-screen features (e.g., TFTs) than prevailing technologies because it exploits field sequential color techniques. Methods to mitigate color break up are presented. TMOS exhibits lower power consumption, lower weight, a simplified architecture, and better visual quality than incumbent display technologies while overcoming their limitations (e.g., poor light efficiency, and size/weight constraints due to yield and backlighting). TMOS should meet avionics needs without additional ruggedization enhancements, offers high immunity to EMP, and can be constructed from transparent materials (allowing z-axis redundancy to improve cockpit ergonomics). Respecting the avionics market, TMOS has advantages over incumbent display technologies, including lower sensitivity to temperature variation, greater immunity to vibration, higher system efficacy (power in to light out), and larger dimming ratios. The status of TMOS development and its fit within avionics applications is addressed.
Extraction of Betel Quid with Supercritical Carbon Dioxide (1993)

Abstract Supercritical extraction with CO 2 as solvent was adopted to remove alkaloids and safrole from the betel quid. The extraction efficiency was significantly affected by the operating pressure and temperature. Results of sensory evaluation showed that the eating qualities of the betel quid decreased but still satisfied the chewer after the extraction treatment.
Hydrogen Ion (H<sup>+</sup>) in Waste Acid as a Driver for Environmentally Sustainable Processes: Opportunities and Challenges (2013)

Acid-base neutralization reaction in the aqueous phase is thermodynamically favorable and kinetically fast. Waste acid neutralization is also the most common waste management practice globally. However, waste acid neutralization is yet to be used for any work/energy generation because of the low concentrations of the waste acid and the high heat capacity of aqueous solutions. In this paper, we address potential processes that can effectively take advantage of the high energy inherent in neutralization reactions, in accordance with the goal of sustainable development.
Gastrointestinal complications of pelvic radiotherapy: are they of any importance? (2005)

Radiation induced bowel damage affects 6000 individuals annually in the UK, with a negative impact on quality of life. Our understanding of how to treat these patients is dismally lacking an evidence base. Fibrosis seems to be the unifying underlying cause for most symptoms. Progress in understanding the development and treatment of fibrosis in these patients might have important consequences for patients with other causes of fibrosis in the gastrointestinal tract
Novel Noninvasive Approach for Detecting Arteriovenous Fistula Stenosis (2014)

Hemodialysis is the most common treatment for patients with end-stage renal disease. For hemodialysis, consistently functional vascular access must be surgically created with an anastomosis of artery and vein, referred to as an arteriovenous fistula (AVF). However, AVF dysfunction may occur over time. Angiography and Doppler ultrasound are usually used to detect the flow or the diameter of the AVF. But they require well-trained operators and are expensive, and even angiography is invasive. In this study, a noninvasive approach based on stethoscope auscultation for monitoring AVF stenosis was proposed. Here, a wireless blood flow sound recorder was designed to record blood flow sounds wirelessly. In order to effectively extract the varying feature of blood flow sounds for AVF stenosis, the 2-D feature pattern built from S-transform was also proposed as the feature in the AVF stenosis detecting algorithm. Different from other frequency-related coefficients, the feature pattern can contain the information of blood flow sounds in time and frequency domains simultaneously. Preliminary findings showed that the proposed approach can provide high-quality estimation of AVF stenosis (positive predictive value = 87.84% and sensitivity = 89.24%).