gebhart/patrepeval huggingface dataset:
Hollow Microspheres of Polyaniline Synthesized with an Aniline Emulsion Template (2002)

Hollow polyaniline microspheres have been synthesized from a monomeric aniline-based template, which makes template removal unnecessary. The template for the microstructures is an aniline emulsion with β-naphthalenesulfonic acid (NSA) as dopant, and ammonium persulfate (APS) as oxidizer. The Figure is a TEM image of polyaniline/NSA spheres obtained from 0.2 M aniline at an NSA/aniline/APS ratio of 1:4:4.
Glycoprotein, elastin, and collagen secretion by rat smooth muscle cells. (1979)

Smooth muscle cells from rat heart secreted extracellular matrix components at high rates for many generations in culture. The matrix proteins remained anchored to the culture dish and were characterized after removal of cellular material with sodium dodecyl sulfate. Sequential enzyme digestion demonstrated the presence of at least three components, including glycoprotein(s), elastin, and collagen. Prolonged extraction of the matrix with detergent under reducing conditions solubilized a fucosylated glycoprotein having an apparent molecular weight of 250,000 and two other proteins with molecular weights of 72,000 and 45,000, respectively. Sublines derived from discrete colonies of smooth muscle cells synthesized all of the matrix components, and the proportion of collagen secreted by some sublines increased with time in culture. The biosynthesis of a mixed extracellular matrix and the relationships among the component proteins were therefore studied in one system producing milligram quantities of material.
Anti-inflammatory Activities of Mogrosides from Momordica grosvenori in Murine Macrophages and a Murine Ear Edema Model (2011)

Momordica grosvenori (Luo Han Guo), grown primarily in Guangxi province in China, has been traditionally used for thousands of years by the Chinese to make hot drinks for the treatment of sore throat and the removal of phlegm. The natural noncaloric sweetening triterpenoid glycosides (mogrosides) contained in the M. grosvenori fruits are also antioxidative, anticarcinogenic, and helpful in preventing diabetic complications. The aim of this study was to assess the anti-inflammatory properties of mogrosides in both murine macrophage RAW 264.7 cells and a murine ear edema model. The results indicate that mogrosides can inhibit inflammation induced by lipopolysaccharides (LPS) in RAW 264.7 cells by down-regulating the expression of key inflammatory genes iNOS, COX-2, and IL-6 and up-regulating some inflammation protective genes such as PARP1, BCL2l1, TRP53, and MAPK9. Similarly, in the murine ear edema model, 12-O-tetradecanoylphorbol-13-acetate-induced inflammation was inhibited by mogrosides by down-regulating COX-2 and IL-6 and up-regulating PARP1, BCL2l1, TRP53, MAPK9, and PPARδ gene expression. This study shows that the anticancer and antidiabetic effects of M. grosvenori may result in part from its anti-inflammatory activity.
A multicenter clinical trial of oral ribavirin in HIV-infected patients with lymphadenopathy. The Ribavirin-LAS Collaborative Group. (1990)

A double-blind, randomized, placebo-controlled trial comparing two daily doses of oral ribavirin and placebo was conducted at four medical centers. One hundred sixty-four adult men with lymphadenopathy were enrolled over a 2-month period and randomized to receive ribavirin 800 mg (53 subjects), ribavirin 600 mg (55 subjects), or placebo (56 subjects). Active treatment was administered for 24 weeks followed by a 4-week washout period. Nine subjects receiving placebo, four receiving ribavirin 600 mg, and none in the 800 mg group developed AIDS during the 24 weeks of active treatment. One patient randomized to the 800 mg group had Kaposi's sarcoma at study entry and was included in the intent-to-treat analysis. An overall significant difference in progression to AIDS was observed among the three treatment groups (p = 0.028) with patients randomized to receive 800 mg having a significantly longer time to AIDS than placebo patients (p = 0.012; relative risk, 9.0; 95% confidence interval, 1.1 to 70.8). There was no significant difference between the 600 mg and placebo groups (p = 0.15; relative risk, 2.3; 95% confidence interval, 0.7 to 7.6). Baseline CD4 cell count and hematocrit made independent contributions and formed a multivariate prognostic set for these progression data. The significant treatment superiority of 800 mg compared to placebo remained after adjustment for these factors (p = 0.019). After deletion of patients with major protocol violations at entry, the difference between the 800 mg and placebo treatment remained significant (p = 0.021).(ABSTRACT TRUNCATED AT 250 WORDS)
Design of an adaptive Smart Card with in-lab experiments (2002)

This work encompasses the study of computer driven technologies for building an efficient and adaptable man-machine interface for the automation of travel-related information and services in IVHS (intelligent vehicle highway systems). Specifically, we plan to develop a "Smart Card" based system to access any travel-related information. The unique feature of the system is that it is based on the personality and preferences of a given user or user-category. The display formats, (e.g. text, audio, hardcopy), interfaces, preference-based queries (e.g. cost, travel time, highway/arterial roads, etc.) will be tailored to the given user/user-category. This will be realized by state-of-the-art ASIC technology called reconfigurable field programmable gate arrays (FPGAs). Since the system can adapt to an individual's (or group of individuals) taste, we expect that it will have greater acceptance by the user community. In addition, the use of FPGAs and modern CAD based design will result in better performance in terms of response time for a given query and decrease the cost of a system, which makes it very practical. Our system will be a significant improvement over the existing Smart Card technologies which are mostly restricted to purchasing tickets in large quantities. The proposed system will take into account both ticketing and access to information services, and serve as a tool for monitoring the performance of an information server.
Smart Devices are Different (2015)

The widespread presence of motion sensors on users' personal mobile devices has spawned a growing research interest in human activity recognition (HAR). However, when deployed at a large-scale, e.g., on multiple devices, the performance of a HAR system is often significantly lower than in reported research results. This is due to variations in training and test device hardware and their operating system characteristics among others. In this paper, we systematically investigate sensor-, device- and workload-specific heterogeneities using 36 smartphones and smartwatches, consisting of 13 different device models from four manufacturers. Furthermore, we conduct experiments with nine users and investigate popular feature representation and classification techniques in HAR research. Our results indicate that on-device sensor and sensor handling heterogeneities impair HAR performances significantly. Moreover, the impairments vary significantly across devices and depends on the type of recognition technique used. We systematically evaluate the effect of mobile sensing heterogeneities on HAR and propose a novel clustering-based mitigation technique suitable for large-scale deployment of HAR, where heterogeneity of devices and their usage scenarios are intrinsic.
Isoproterenol Induced Cerebral Hypoperfusion in a Heart Transplant Recipient (1993)

To determine the effect of tilt isoproterenol provocation on cerebral perfusion in a patient with denervated heart, transcranial Doppler sonography was used to assess changes in cerebral blood flow velocity during upright tilt test. A 51-year-old man with history of syncopal spells after heart transplantation was evaluated by using upright tilt test with and without isoproterenol for 30 minutes, respectively, at 80 degrees inclined. Mean cerebral blood flow was measured in the main stem of the right middle cerebral artery. Blood pressure and heart rate were noninvasively monitored. Tilt isoproterenol provocation but not tilt alone induced a significant reduction in cerebral blood flow velocity, without remarkable hypotension. There was no change in respiratory activity. This may indicate that vagal reflexes are not implicated in the mechanism of isoproterenol to induce cerebral hypoperfusion and hence neurally mediated syncope.
Synthesis of Symmetrical and Unsymmetrical <b><i>N</i></b>-Aryl-Substituted Cyclic Ureas through Copper(I) Iodide Catalyzed Goldberg-Buchwald-Nandakumar C-N Coupling Reactions (2008)

The catalytic conditions of copper(I) iodide/potassium carbonate/trans-N,N′-dimethylcyclohexane-1,2-diamine, either in toluene at reflux temperature, or by heating neat at 150 °C effectively promoted the C-N coupling of aryl bromides with cyclic ureas. By employing a protection-deprotection strategy, unsymmetrical diaryl-substituted cyclic ureas could also be synthesized.
Multidimensional persistence in biomolecular data (2015)

Persistent homology has emerged as a popular technique for the topological simplification of big data, including biomolecular data. Multidimensional persistence bears considerable promise to bridge the gap between geometry and topology. However, its practical and robust construction has been a challenge. We introduce two families of multidimensional persistence, namely pseudomultidimensional persistence and multiscale multidimensional persistence. The former is generated via the repeated applications of persistent homology filtration to high-dimensional data, such as results from molecular dynamics or partial differential equations. The latter is constructed via isotropic and anisotropic scales that create new simiplicial complexes and associated topological spaces. The utility, robustness, and efficiency of the proposed topological methods are demonstrated via protein folding, protein flexibility analysis, the topological denoising of cryoelectron microscopy data, and the scale dependence of nanoparticles. Topological transition between partial folded and unfolded proteins has been observed in multidimensional persistence. The separation between noise topological signatures and molecular topological fingerprints is achieved by the Laplace-Beltrami flow. The multiscale multidimensional persistent homology reveals relative local features in Betti-0 invariants and the relatively global characteristics of Betti-1 and Betti-2 invariants.
Security offload using the SmartNIC, A programmable 10 Gbps ethernet NIC (2015)

The SmartNIC is a User-Programmable 10GE NIC designed around industry standards to meet the demands of high performance networking in HPC and datacenter communities. The SmartNIC enables application-specific offload engines to be developed. Application developers can implementation application-aware offload engines, network developers can test and develop network protocol offload engines, and researchers can test and develop new offload protocols and middleware. The available hardware offload engines facilitate that development and can improve the performance and scalability of high performance applications, including Data Center applications, large-scale parallel file systems, HPC applications, security/encryption, Big Data, and similar areas.
Simulation of falling rain for robustness testing of video-based surround sensing systems (2016)

Recently, optical sensors have become a standard item in modern cars, raising questions with respect to the necessary testing under various ambient effects. In order to achieve a high test coverage of vision-based surround sensing systems, a lot of different environmental conditions need to be tested. Unfortunately, it is by far too time-consuming to build test sets of all relevant environmental conditions by recording real video data. This paper presents a novel approach for ambient-aware virtual prototyping and robustness testing. We propose a method to significantly reduce the needed on-road recordings being used for design and validation of vision-based Advanced Driver Assistance Systems (ADAS) and fully automated driving. Our approach facilitates the generation of comparable test sets by using largely reduced amounts of real on-road recordings and applying computer-generated variations of falling rain to it in a comprehensive virtual prototyping environment. In combination with the simulation of camera properties, which influence the visual effects of falling rain to a great extent, we are able to generate different rain scenarios under a wide variety of parameters. Our approach has been applied to an automotive lane detection system using a series of multiple rain scenarios. We have explored, how falling rain can influence such a system and how such behavior can be detected using simulated rain scenarios.
Anchorage-dependent Cell Cycle Progression (1997)

The concept of anchorage-dependent growth and the close relationship between anchorage independence and tumorigenicity were first appreciated more than a quarter century ago ([9][1], [16][2], [23][3], [24][4]). Penman and his coworkers then showed that incubation of cells in the absence of
Validating plastic scintillation detectors for photon dosimetry in the radiologic energy range (2012)

In the diagnostic energy range, PSDs show high-energy dependence, which can be corrected using spectra-weighted mass energy-absorption coefficients, showing no considerable sign of quenching between these energies. Correction factors obtained by Monte Carlo simulations confirm that the approximations made by LCT corrections are valid. Thus, PSDs could be useful for real-time dosimetry in radiology applications.
Putative Nonribosomal Peptide Synthetase and Cytochrome P450 Genes Responsible for Tentoxin Biosynthesis in Alternaria alternata ZJ33 (2016)

Tentoxin, a cyclic tetrapeptide produced by several Alternaria species, inhibits the F₁-ATPase activity of chloroplasts, resulting in chlorosis in sensitive plants. In this study, we report two clustered genes, encoding a putative non-ribosome peptide synthetase (NRPS) TES and a cytochrome P450 protein TES1, that are required for tentoxin biosynthesis in Alternaria alternata strain ZJ33, which was isolated from blighted leaves of Eupatorium adenophorum. Using a pair of primers designed according to the consensus sequences of the adenylation domain of NRPSs, two fragments containing putative adenylation domains were amplified from A. alternata ZJ33, and subsequent PCR analyses demonstrated that these fragments belonged to the same NRPS coding sequence. With no introns, TES consists of a single 15,486 base pair open reading frame encoding a predicted 5161 amino acid protein. Meanwhile, the TES1 gene is predicted to contain five introns and encode a 506 amino acid protein. The TES protein is predicted to be comprised of four peptide synthase modules with two additional N-methylation domains, and the number and arrangement of the modules in TES were consistent with the number and arrangement of the amino acid residues of tentoxin, respectively. Notably, both TES and TES1 null mutants generated via homologous recombination failed to produce tentoxin. This study provides the first evidence concerning the biosynthesis of tentoxin in A. alternata.
Addition of 1,3,4-Thiadiazole-2,5-dithiol to Olefinic Compounds (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition of 1,3,4-Thiadiazole-2,5-dithiol to Olefinic CompoundsELLIS K. FIELDSCite this: J. Org. Chem. 1956, 21, 5, 497–499Publication Date (Print):May 1, 1956Publication History Published online1 May 2002Published inissue 1 May 1956https://pubs.acs.org/doi/10.1021/jo01111a002https://doi.org/10.1021/jo01111a002research-articleACS PublicationsRequest reuse permissionsArticle Views247Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Some statistical properties of median filters (1981)

Some statistical properties of median filters are analyzed. It is shown that median filters can remove impulsive plus Gaussian white noise better than Hanning filters when the amplitude of the impulses is large or the energy of the Gaussian noise is relatively low. It is also shown that, unlike linear filters, median filters preserve sharp changes in signals when the noise energy is not too high.
Identification of 3<i>H</i>-Naphtho[1,2,3-<i>de</i>]quinoline-2,7-diones as Inhibitors of Apoptosis Signal-Regulating Kinase 1 (ASK1) (2011)

Apoptosis signal-regulating kinase 1 (ASK1) has recently emerged as an attractive therapeutic target for the treatment of cardiac and neurodegenerative disorders. The selective inhibitors of ASK1 may become important compounds for the development of clinical agents. We have identified the ASK1 inhibitor among 3H-naphtho[1,2,3-de]quinoline-2,7-diones using receptor-based virtual screening. In vitro kinase assay revealed that ethyl 2,7-dioxo-2,7-dihydro-3H-naphtho[1,2,3-de]quinoline-1-carboxylate (NQDI-1) inhibited ASK1 with a K(i) of 500 nM. The competitive character of inhibition is demonstrated in Lineweaver-Burk plots. In our preliminary selectivity study this compound exhibited strong specific inhibitory activity toward ASK1.
A Novel and Simple Solvent Free Method for Nucleophilic Aromatic Substitution of Inactive Aryl Halides (2004)

Abstract A simple, high yield, and short time method for nucleophilic displacement reaction of inactive aryl halides is reported. The reaction is performed in microwave oven under thermal condition with montmorillonite supported AgNO3. Keywords: Aryl halidesNucleophilic substitutionSolvent freeMontmorillonite K10
Relative Role of Phospholipids, Triacylglycerols, and Cholesterol Esters on Malonaldehyde Formation in Fat Extracted from Chicken Meat (1984)

ABSTRACT Fresh breast and leg meat was collected from 11‐wk‐old pullets fed a high protein‐low fat starter ration. Lipid oxidation measured in malonaldehyde (MA) equivalents in total fat extracted from meat, and in phospholipids (PL), triacylglycerol (TG), and cholesterol ester (CE) fractions of total fat was determined by an improved TBA assay with antioxidant protection. It was found that breast meat had two‐fold less fat than leg. Breast fat contained 70.1% PL, 22.2% TG, and 1.2% CE; leg fat contained 42.9% PL, 51.4% TG, and 0.8% CE. After separation by thin layer chromatography, the individual lipid classes were tested for TBA reactivity. The PL fraction was found to contribute approximately 90% of the MA measured in total fat from chicken meat.
Evaluation of Status and Progression of HIV Disease: Use of a Computerized Medical Module (2001)

SUMMARY The Northern Nevada HOPES (HIV Outpatient Program, Education, and Services) Clinic provides comprehensive and consultative care to persons living with HIV/AIDS in Reno, Nevada. As a method of tracking clinical data for evaluation purposes, a computer database was designed and implemented in the clinic setting. Analysis of these data permitted an exploration of the relations among client behaviors such as substance abuse and clinical markers of HIV disease progression. Substance abuse was found to be related to a number of indicators of impaired health. The computerized medical data module was found to be a useful tool for evaluation and quality assurance purposes and permitted the quantification of substance abuse behaviors in the clinic population.
Acid-Induced Unfolding of Flounder Hemoglobin:  Evidence for a Molten Globular State with Enhanced Pro-oxidative Activity (2002)

The acid-induced unfolding of flounder oxyhemoglobin was investigated and the effect on pro-oxidative activity assessed. Hemoglobin exhibited multistep unfolding transitions as pH was lowered, with the major transition between pH 3.5 and 4 5. The protein was maximally acid-unfolded (but not fully unfolded) at approximately pH 2.5, and further titration with HCl led to a partially refolded protein due to a stabilizing effect of Cl(-) anions. At low pH, the protein retained a sizable amount of secondary structure and had increased ANS binding, suggesting a molten globular form at low pH. Dramatic changes in the heme environment occurred concurrently with the changes in protein conformation. These changes resulted in an enhancement in the pro-oxidative activity of the protein. The results show that an increase in flounder hemoglobin pro-oxidation was correlated with the extent of its unfolding, and they provide useful insight into what may occur with hemoglobin in processes where highly acidic conditions are employed.
Cavity-size-dependent dissociation of crown ether/ammonium ion complexes in the gas phase (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCavity-size-dependent dissociation of crown ether/ammonium ion complexes in the gas phaseSimin Maleknia and Jennifer BrodbeltCite this: J. Am. Chem. Soc. 1993, 115, 7, 2837–2843Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ja00060a034https://doi.org/10.1021/ja00060a034research-articleACS PublicationsRequest reuse permissionsArticle Views1176Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Risk-Reduction Processes in Repetitive Consumer Behavior (1968)

This experimental study of consumer decision making over time explored risk-reduction processes of information seeking, prepurchase deliberation, and brand loyalty. Perceived risk was manipulated by creating low-risk and high-risk groups. The task was to choose among brands of hair spray. Results showed that information seeking and prepurchase deliberation declined over time and brand loyalty increased over time.