gebhart/patrepeval huggingface dataset:
Click Chemistry and Material Selection for <i>in Situ</i> Fabrication of Hydrogels in Tissue Engineering Applications (2018)

This Review gives a brief introduction to hydrogels formed through click chemistry for applications in tissue engineering. Specifically, we focus on three representative click chemistry mechanisms: Diels-Alder reactions, azide-alkyne cycloaddition, and thiol-ene chemistry. Apart from that, we also discuss photoinitiated chain growth polymerization, which also has fast kinetics. The chemical mechanisms of these reactions, along with their advantages and disadvantages, are presented. These gelation methods are compared and contrasted with other methods of forming hydrogels. Further, we offer an insight on the fabrication of click chemistry hydrogels from a material selection perspective. Commonly used materials from both synthetic and naturally derived polymer families were selected and discussed with their special features and drawbacks in fabricating hydrogels used in tissue engineering applications. At the end, the impact of cross-linking mechanisms and hydrogels properties on the host response is discussed. In conclusion, click reactions are modular and stereospecific. These reactions proceed rapidly with high selectivity, which means they have the potential to be formed <i>in situ</i> with minimal interference on biological processes. In order to achieve optimal hydrogels for tissue engineering applications, it is important to consider different design principles and material fabrication strategies to develop optimal hydrogels for regenerative medicine applications.
A 0.6-V 82-dB 28.6-$\mu$W Continuous-Time Audio Delta-Sigma Modulator (2011)

The design of a low-voltage low-power fourth-order single-bit continuous-time Delta-Sigma modulator is presented in this paper for audio applications. The modulator employs an input-feedforward topology in order to reduce internal signal swings, thus relaxes the linearity and slew rate requirements on amplifiers leading to low-voltage operation and low-power consumption. The energy efficiency is further improved by embedding the summation of feedforward paths into the quantizer. For low-voltage operation, a gain-enhanced fully-differential amplifier and a body-driven rail-to-rail input CMFB circuit are developed. The modulator, implemented in a 0.13- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu{\hbox{m}}$</tex> </formula> standard CMOS technology with a core area of 0.11 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">${\hbox{mm}}^{2}$</tex></formula> , achieves an 82-dB dynamic range (DR), and a 79.1-dB peak signal-to-noise and distortion ratio (SNDR) over a 20-kHz signal bandwidth. The power consumption of the modulator is 28.6 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu\hbox{W}$</tex> </formula> under a 0.6-V supply voltage. The achieved performance make it one of the best among state-of-the-art sub-1-V modulators in terms of two widely used figures of merit.
Effect of Time Delay on Ensemble Accuracy (2004)

Pairs of musicians were placed apart in isolated rooms and asked to clap a rhythm together. Each person monitored the other’s sound via headphones and microphone pickup was as close as possible. Time delay from source to listener was manipulated across trials. Trials were recorded and clap onset times were measured with an event detection algorithm. Longer delays produced increasingly severe tempo deceleration and shorter delays (&lt; 11.5 ms) produced a modest, but surprising acceleration. The study’s goal is to characterize effects of delay on rhythmic accuracy and identify the region most conducive to ensemble playing. The results have implication for networked musical performance. Network delay is a function of transmission distance and / or internetworking (routing) delays. The findings suggest that sensitive ensemble performance can be supported over rather long paths (e.g., San Francisco to Denver at about 20 ms, oneway). The finding that moderate amounts of delay are beneficial to tempo stability seems, at first glance, counterintuitive. We discuss the observed effect. 1.
Adsorption of a Polyampholyte Chain on a Charged Surface (1997)

We discuss the adsorption of a single polyampholyte chain with degree of polymerization N carrying Nf charges, (Nf+ positive and Nf- negative charges) on a charged surface with σ charges per unit area. The adsorption is due to the electrostatic polarization of the polyampholyte chain, which acquires a dipole moment in the surface electric field. Symmetric Gaussian polyampholytes with equal numbers of positive and negative charges adsorb if the surface charge density σ is larger than (1/alBN)· (1/f 1/2) (lB is the Bjerrum length and a is the bond size). Polyampholyte chains carrying a charge of the same sign as the surface can also adsorb if the surface charge is large enough. For a typical asymmetry |f- − f+| ≈ (f/N)1/2, the adsorption threshold is σ > (1/alBN3/4)(1/f 1/4). The effect of the added salt on the adsorption is considered. Finally, we determine the adsorption threshold of a collapsed polyampholyte globule.
Peripheral blood T cell expansions in patients with Behcet's disease (1997)

Behçet's disease (BD) is a chronic multisystemic inflammatory disorder characterized mainly by recurrent oral and genital aphthous ulcerations and uveitis. Etiology and pathogenesis of BD remain unknown. T cell receptor (TCR) V alpha/V beta gene product expression as well as Jbeta gene segment expression in peripheral blood of BD patients were analysed to investigate the possible role of T lymphocytes in the etiopathogenesis of BD. Flow cytometry with 12 TCR V-specific MoAbs was used for TCRV analyses. Jbeta gene segment usage by T cell populations expressing certain V betas was determined by polymerase chain reaction (PCR) technique with V beta- and C beta-specific primers, Southern blotting of PCR products, and subsequent hybridization with radiolabelled Jbeta gene segment-specific probes. Although 13 of the 23 BD patients exhibited increases in expression of one or more TCR V-gene products, only expansions among the CD4+ T cell subset were significantly more frequent in BD patients (7/23) compared with healthy controls (0/15) (P = 0.019). Six out of eight cases followed for up to 20 months had at least one expansion correlated with disease activity. A strict preference for particular Jbeta gene segments implicating clonality was apparent in all analysed T cell expansions and correlated well with disease activity. These results suggest a possible involvement of antigen-specific T lymphocytes in the pathogenesis of BD.
Mitochondrial proton leak in brown adipose tissue mitochondria of<i>Ucp1</i>-deficient mice is GDP insensitive (1999)

Mice deficient in mitochondrial uncoupling protein (UCP) 1 are cold sensitive, despite abundant expression of the homologues, Ucp2 and Ucp3 (S. Enerbäck, A. Jacobsson, E. M. Simpson, C. Guerra, H. Yamashita, M.-E. Harper, and L. P. Kozak. Nature 387: 90-94, 1997). We have analyzed characteristics of mitochondrial proton leak from brown adipose tissue (BAT) of Ucp1-deficient mice and normal controls and conducted the first top-down metabolic control analysis of oxidative phosphorylation in BAT mitochondria. Because purine nucleotides inhibit UCP1 and because UCP2 and the long form of UCP3 have putative purine nucleotide-binding regions, we predicted that proton leak in BAT mitochondria from Ucp1-deficient mice would be sensitive to GDP. On the contrary, although control over mitochondrial oxygen consumption and proton leak reactions at state 4 are strongly affected by 1 mM GDP in mitochondria from normal mice, there is no effect in UCP1-deficient mitochondria. In the presence of GDP, the overall kinetics of proton leak were not significantly different between Ucp1-deficient mice and controls. In its absence, state 4 respiration in normal BAT mitochondria was double that in its presence. Leak-dependent oxygen consumption was higher over a range of membrane potentials in its absence than in its presence. Thus proton leak, potentially including that through UCP2 and UCP3, is GDP insensitive. However, our measurements were made in the presence of albumin and may not allow for the detection of any fatty acid-induced UCP-mediated leak; this possibility requires investigation.
Inverse filtering of room impulse response for binaural recording playback through loudspeakers (2002)

We propose a system to achieve playback of binaural dummy head recordings through loudspeakers by ensuring crosstalk cancellation and equalization for loudspeaker and listener head related transfer functions in anechoic conditions. This system can run at a sampling frequency of 32 kHz using available DSP chips.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Laser material processing in the aero engine industry. Established, cutting-edge and emerging applications (2008)

Laser machining processes are widely used in the manufacture and repair of aero engine components. This paper provides examples of well-established, cutting-edge and emerging laser machining processes. A well-established process is laser metal deposition or laser cladding which is predominantly used to restore worn blade tips and seal fins. But the process also has the potential to restore complete airfoils of integral rotors, also known as bladed disks or blisks. In the FLEXILAS-project sponsored by the German Federal Ministry of Education and Research it was demonstrated that the quality of laser generated blisk blades is comparable to that of new ones.
Design and Development of the TerraStar Marginal-Terrain Amphibian (1968)

<div class="htmlview paragraph">Many off-the-road mobility development programs have had as the principal objective a substantial improvement in soft-soil performance. This paper describes the evolution of the TerraStar marginal-terrain amphibian, which represents an effort to achieve this improvement without sacrificing “readability.” The TerraStar concept is based on the use of a new locomotion device called a major/minor wheel. Essentially an “interrupted” wheel, this device works down in soft soils much like a spaced-link track, and also provides wheeled vehicle performance on roads and highways, or hard ground.</div> <div class="htmlview paragraph">Aspects of the program related here include the use of scale-model tests in natural soils for preliminary design, the development of full-scale experimental vehicles, and the early results of field tests of the full-scale vehicles.</div>
Handling Hand Hygiene in Day Surgery (2010)

The National Hand Hygiene Initiative (NHHI) is aimed at developing a national programme to reduce the rate of Healthcare-Associated Infection (HCAI), improve hand hygiene compliance rates and educate healthcare providers on the issue. The article highlights the importance of hand hygiene, particularly in day surgery units, and offers suggestions on how health workers can be associated with the NHHI.
Amyloid Precursor Protein: From Synaptic Plasticity to Alzheimer's Disease (2005)

The amyloid precursor protein (APP) has been shown to be implicated in age-associated plastic changes at synapses that might contribute to memory loss in Alzheimer's disease. As APP has previously been reported to have multiple functions during normal development, and as human and avian APP share 95% homology in amino acid sequence, we have employed a one-trial passive avoidance task in day-old chicks to study its role in the process of memory formation. Administration of anti-APP antibodies, raised against human APP, APP-antisense, and Abeta during pre-training, prevented memory formation without effects on general behavior or initial acquisition. Amnesia is apparent by 30 min post-training and lasts for at least 24 hours. Injection of APP-derived peptides RERMS (APP(328-332)) and RER (APP(328-330)) homologous to the short stretches of amino acids in the Kang sequence (APP(319-335)), rescue the memory in animals rendered amnestic by previous (anti-APP antibody, antisense, and Abeta pretreatments. The protected form of RER, with a prolonged half-life (acetylated RER), proved to be effective when injected intracranially and peripherally. The tripeptide RER exerts its biological activity by binding to two neuronal plasma membrane proteins (60 and 110 kDa). The results obtained in this study suggest that RER alleviates memory deficits via receptor-mediated events, and that short APP-derived peptides might represent a novel group of therapeutically active molecules for the alleviation of memory deficits in age-related dementias.
Controlling Protein−Protein Interactions through Metal Coordination:  Assembly of a 16-Helix Bundle Protein (2007)

The prediction, design, and control of protein−protein interactions (PPIs) remain great challenges despite recent advances. Here we describe the chemical control of PPIs through the use of metal coordination, which circumvents the requirement of PPIs for an extensive set of weak interactions spread over a large surface. A non-self-associating four-bundle protein, cytochrome cb562, with appropriately engineered metal-binding motifs self-assembles to a 16-helix quaternary structure upon addition of equimolar Zn. The crystal structure of the assembly, combined with PFG diffusion NMR and sedimentation velocity experiments, indicates that the oligomerization properties of cytochrome cb562 are governed entirely by metal coordination without significant thermodynamic bias from specific PPIs.
2009 Sino−Australian Symposium on Advanced Coal and Biomass Utilisation Technologies (2009)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXT2009 Sino−Australian Symposium on Advanced Coal and Biomass Utilisation TechnologiesHongwei Wu and Minghou XuView Author Information Curtin Centre for Advanced Energy Science and Engineering, Department of Chemical Engineering, Curtin University of Technology, GPO Box U1987, Perth, Western Australia 6845, Australia State Key Laboratory of Coal Combustion, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, Hubei Province, ChinaCite this: Energy Fuels 2010, 24, 1, 1Publication Date (Web):November 12, 2009Publication History Received3 November 2009Published online12 November 2009Published inissue 21 January 2010https://pubs.acs.org/doi/10.1021/ef901291rhttps://doi.org/10.1021/ef901291reditorialACS PublicationsCopyright © 2009 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1341Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (553 KB) Get e-AlertscloseSUBJECTS:Biomass,Coal,Energy,Redox reactions Get e-Alerts
Love in the Time of Capital (2018)

This is the author accepted manuscript. The final version is available from Johns Hopkins University Press via the DOI in this record
The Objective Request‐for‐Proposal (1986)

A Request‐for‐Proposal (RFP) performs four functions, including preparing staff for systems implementation. Traditional RFPs have been characterized by detailed performance (functional) and hardware specifications, but these RFPs may not adequately address differences in systems design, philosophy, expandability, and related issues. They also discourage vendor responses. An alternative “objective RFP” (and its benefits/ liabilities) is discussed.
A class of multiprocessors for real-time image and multidimensional signal processing (1988)

A 90000-transistor, 50-MIPS (million-instruction-per-second) multiprocessor chip designed for image orthogonal transform is discussed. The architectural principle, derived from a tensorial formalism, is usable for the other linear processings of multidimensional signals (e.g. n-dimensional convolution). A regularity factor of more than 99% was obtained by taking advantage of systolic principles at both chip and bit levels.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Real-Time Multi-agent Forecasting and Replenishment Solution for LEGOs Branded Retail Outlets (2012)

The paper describes main features of a real-time forecasting and scheduling multi-agent solution designed for the LEGO Company. The design is based on Knowledge Genesis Group own multi-agent platform and technology, which provide real-time adaptive event-driven scheduling to replenish products to LEGO Branded Retail stores. The prototype system has been used to schedule 20 US-based LEGO retail outlets for a yearlong trial period and has achieved the following results:Reduction of lost sale from 40% to 16%; Increase in service level from 66% to 86%;Increase in profitability 56% to 81%. The results show a considerable potential value for full scale LEGO supply chain multi-agent solution which would be able to dynamically and adaptively re-schedule deliveries in real time.
A Case of Pachydermodactyly (2014)

Pachydermodactyly is a form of digital dermal fibromatosis of unknown etiology, characterized by asymptomatic soft tissue swelling on the lateral aspects of the proximal interphalangeal joints of the hands. It usually affects young men and often associated with repetitive mechanical trauma. As a rule, it is a benign condition and a specific therapy or extensive investigation is not necessary in most cases. However, pachydermodactyly is not well recognized by physician.
Design of Phased Arrays of Series-Fed Patch Antennas With Reduced Number of the Controllers for 28-GHz mm-Wave Applications (2015)

New modified 2 × 2 and 3 × 3 series-fed patch antenna arrays with beam-steering capability are designed and fabricated for 28-GHz millimeter-wave applications. In the designs, the patches are connected to each other continuously and in symmetric 2-D format using the high-impedance microstrip lines. In the first design, 3-D beam-scanning range of ± 25° and good radiation and impedance characteristics were attained by using only one phase shifter. In the second one, a new mechanism is introduced to reduce the number of the feed ports and the related phase shifters (from default number 2 N to the reduced number N + 1 in the serial feed (here N = 3) and then the cost, complexity, and size of the design. Here, good scanning performance of a range of ± 20°, acceptable sidelobe level, and gain of 15.6 dB are obtained. These features allow to use additional integrated circuits to improve the gain and performance. A comparison to the conventional array without modification is done. The measured and simulated results and discussions are presented.
DS-CDMA wired bus with simple interconnection topology for parallel processing system LSIs (2002)

A new bus architecture is described which is suitable for a parallel processing system without complexity of interconnection, and also drastically reduces the I/O pin count, which is highly desirable for future gigascale integrated systems. The architecture is based on the direct sequence code division multiple access (DS-CDMA) technique.
Comorbidity of DSM–III–R Major Depressive Disorder in the General Population: Results from the US National Comorbidity Survey (1996)

General population data are presented on the prevalence and correlates of comorbidity between DSM-III-R major depressive disorder (MDD) and other DSM-III-R disorders. The data come from the US National Comorbidity Survey, a large general population survey of persons aged 15-54 years in the non-institutionalised civilian population. Diagnoses are based on a modified version of the Composite International Diagnostic Interview (CIDI). The analysis shows that most cases of lifetime MDD are secondary. In the sense that they occur in people with a prior history of another DSM-III-R disorder. Anxiety disorders are the most common primary disorders. The time-lagged effects of most primary disorders on the risk of subsequent MDD continue for many years without change in magnitude. Secondary MDD is, in general, more persistent and severe than pure or primary MDD. This has special public health significance because lifetime prevalence of secondary MDD has increased in recent cohorts, while the prevalence of pure and primary depression has remained unchanged.
Nonparametric belief propagation for self-calibration in sensor networks (2004)

Automatic self-calibration of ad-hoc sensor networks is a critical need for their use in military or civilian applications. In general, self-calibration involves the combination of absolute location information (e.g. GPS) with relative calibration information (e.g. time delay or received signal strength between sensors) over regions of the network. Furthermore, it is generally desirable to distribute the computational burden across the network and minimize the amount of inter-sensor communication. We demonstrate that the information used for sensor calibration is fundamentally local with regard to the network topology and use this observation to reformulate the problem within a graphical model framework. We then demonstrate the utility of nonparametric belief propagation (NBP), a recent generalization of particle filtering, for both estimating sensor locations and representing location uncertainties. NBP has the advantage that it is easily implemented in a distributed fashion, admits a wide variety of statistical models, and can represent multi-modal uncertainty. We illustrate the performance of NBP on several example networks while comparing to a previously published nonlinear least squares method.