gebhart/patrepeval huggingface dataset:
Cisplatin, Etoposide, and Paclitaxel in the Treatment of Patients With Extensive Small-Cell Lung Carcinoma (1999)

The combination of cisplatin, etoposide, and paclitaxel produced response and survival rates similar to those of other combinations and was well tolerated.
Understand practice, compliance issues of pandemic‐driven telework environment (2020)

Through jarring, health‐crisis‐driven forced closures, the vast majority of employees for many colleges and universities began conducting their work from home. As institutions phase into the next academic year, ongoing telework arrangements and employment laws are likely to become more prominent administration challenges and legal risk areas.
Phenol-functionalized polymerization control additives for negative tone epoxide crosslinking molecular resists (2018)

Controlling undesired polymerization in nominally unexposed regions is critical to achieving high-resolution, defect-free patterns when using negative tone molecular resists based on the crosslinking of epoxides. Two onium salt additives, a photodecomposable nucleophile (PDN) and a photoacid generator (PAG), were functionalized with phenols in order to investigate their use as generalized additives capable of slowing crosslinking and improving the resolution of a variety of epoxide resists. Presented here is a phenol-functionalized PDN [tris(4-hydroxyphenyl)sulfonium triflate (TPS-OH-Tf)] and a phenol-functionalized PAG [tris(4-hydroxyphenyl)sulfonium antimonate (TPS-OH-SbF6)] used in combination with a model epoxide resist (4-Ep). Utilizing additives that contained phenols resulted in a decrease in resist sensitivity, but enabled higher additive loadings which could be used to offset this loss in sensitivity. Using TPS-OH-SbF6 did not provide enough polymerization control to prevent line broadening, and the use of TPS-OH-Tf was still required to achieve sub 35 nm 1:1 line:space patterns. Adding TPS-OH-Tf was also found to improve pattern collapse behavior at reduced (&lt;25 nm) feature sizes. Initial patterning using 100 keV electron-beam lithography showed that the resolution of 4-Ep was improved to 15 nm 1:1 line:space patterns using these phenol-functionalized additives and demonstrate the potential of these additives to improve the resolution of a variety of epoxide crosslinking molecular resists.
As interfaces da bioética nas pesquisas com seres humanos e animais com a biossegurança (2008)

Define-se etica como a ciencia dos fundamentos ou principios da acao humana, ou seja, os criterios e teorias que regem o comportamento correto do homem e a Bioetica como a aplicacao dos conceitos eticos a Biologia e a Medicina. Historicamente a palavra Bioetica foi criada pelo oncologo Van Rensselder Potter em 1971, sugerindo o autor que deve haver uma ligacao da ciencia com sua aplicacao, visando a defesa dos valores humanos. O titulo do seu livro, Bioetica: uma ponte para o futuro, define bem o alcance e a profundidade do tema para a sociedade humana como um todo. A Bioetica exige uma conjuncao de varias disciplinas, visando a correta utilizacao dos conhecimentos adquiridos pela ciencia; ela deve unir a Etica e a Biologia, os valores eticos e os fatos biologicos. Ela e norteada por determinados principios como a beneficencia,a prudencia,a autonomia, a justica ea responsabilidade.
A structured approach to product and process optimization formanufacturing and service industries (1995)

Continuous improvement is a cyclic process of product and process optimization over a product life cycle. Optimization is beyond quality and reliability management – meaning, an organization is keeping in constant touch with new technological advances and frequently employs the applicable technologies to improve an existing product. Cycling means that an organization is continually exploring new frontiers in manufacturing technologies. The latest advances in related fields such as computers and systems are reviewed regularly for possible inclusion in the produced and process optimization cycle. Today, there is no single unique structure or process that defines “continuous improvement”, or, in a larger sense, what is described here as product and process optimization (PPO). Outlines a new structured approach to product and process optimization which includes, in addition to change management, three sets of metrics and measurements. PPO is a function of life‐cycle management. There are three aspects of life‐cycle management applicable to manu‐facturing and service industries: managing reprocessing, restructuring or re‐engineering change; managing continuity; and managing revision change.
Glycochimie et thérapeutique: Les cyclodextrines en Pharmacie, perpectives pour le ciblage d'actifs thérapeutiques et le contrôle d'interactions membranaires (2007)

International audience
Elevated Concentrations of Serum Immunoglobulin Free Light Chains in Systemic Lupus Erythematosus Patients in Relation to Disease Activity, Inflammatory Status, B Cell Activity and Epstein-Barr Virus Antibodies (2015)

SLE patients have elevated concentrations of serum FLCs that correlate with global disease activity scores and especially serologic markers for active disease. These findings are suggestive of circulating FLCs having potential as a new supplementary serologic biomarker in SLE.
Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee (2012)

The increasing prevalence of painful knee osteoarthritis has created an additional demand for pharmacologic management to prevent or delay surgical management. Viscosupplementation, via intraarticular injection of hyaluronic acid (HA), aims to restore the favorable milieu present in the nonarthritic joint. The safety profile of intraarticular HA injections for painful knee osteoarthritis is well established, with the most common adverse effect being a self-limited reaction at the injection site. Although acceptance of the early literature has been limited by publication bias and poor study quality, more recent and rigorous meta-analysis suggests that intraarticular HA injection is superior to placebo injection for pain relief and matches, if not surpasses, the effect size of other nonoperative treatments, such as nonsteroidal anti-inflammatory medication. Intraarticular HA injection is effective in providing temporary pain relief in patients with painful knee osteoarthritis. Future investigations should focus on optimizing the composition and administration of HA agents to provide prolonged relief of painful osteoarthritis in the knee and other joints.
C-Banding in Maize. I. Band Patterns (1985)

SUMMARYThe C-banded karyotypes of several maize stocks, including one with knobs in almost all positions known in maize chromosomes, are presented together with the evidence that large C-bands or knobs alter the relative arm length of the chromosomes involved. All the aspects of the differential Giemsa staining are discussed, including the centromeric heterochromatin, Nucleolar Organizing Region (NOR) heterochromatin, the satellite of chromosome 6, as well as the heterochromatic segments of the B-chromosomes observed both in mitotic metaphase and at the pachytene stage of meiosis.
Mutual coupling effects correction in microstrip arrays for direction-of-arrival (DOA) estimation (2002)

The presence of mutual coupling severely degrades the performance of an adaptive array. A simple method based on obtaining an N×N coupling matrix, C, to compensate for the coupling effects in direction-of-arrival (DOA) estimation algorithms is presented. It is based on the theory of characteristic modes in conjunction with an element-by-element analysis of finite arrays. As a small number of characteristic modes are needed to yield a good approximation of induced currents, the method significantly reduces the computational effort in calculating the unknowns. Its application to the MUSIC algorithm results in good and efficient performance.
Some results about the behaviour of the characteristic frequencies in electric circuits (2002)

In this work calculations of characteristic modes in electric circuits are shown by using the Lagrangian formulation. The effects of changing the values of the elements of the circuit upon the characteristic modes, are also studied. Also, the results point out that the effect of removing a branch in the circuit, determine as a consequence, that the new characteristic modes are inserted among the old ones. In summary, we can obtain as a first approximation some information about the behaviour of the characteristic frequencies of circuits subjected to changing conditions or imposed constraints, by linearization of their equivalent Lagrangian system in the neighborhood of an equilibrium state, and by applying to the latter some results deriving from the Rayleigh-Courant-Fisher theorem for systems performing small oscillations.
Premature Ventricular Contraction-induced Cardiomyopathy (2017)

Premature ventricular contractions (PVCs) are very common and usually do not require treatment. However, in the clinical setting of troublesome symptoms, or when PVCs trigger polymorphic ventricular tachycardia or cause cardiomyopathy, proper treatment is critical. In this review, the clinical syndrome of PVC-induced cardiomyopathy, including risk factors for development and treatment, is discussed. Although PVC-induced cardiomyopathy is typically associated with frequent PVCs there are also patients with this burden that do not develop cardiomyopathy, suggesting a differential susceptibility. Treatment often consists of catheter ablation, although antiarrhythmic medications may also provide both reduction in PVC frequency and resolution of left ventricular dysfunction.
Spatial-Mode Analysis of Micromachined Optical Cavities Using Electrothermal Mirror Actuation (2006)

The performance of optical microcavities is limited by spectral degradation resulting from thermal deformation and fabrication imperfections. In this paper, we study the spatial-mode properties of micromirror optical cavities with respect to commonly seen aberrations. Electrothermal actuation is used to slightly adjust the shape and position of micromirrors and study the effects this has on the spatial-mode structure of the cavity spectrum. The shapes of the micromirrors are changed using Joule heating with thermal expansion deformation. Significant differences in mirror tilt, curvature, and astigmatism are measured, but the tilt has by far the biggest impact on cavity finesse and resolution. We demonstrate that unwanted higher order spatial modes can be suppressed electrically and an amplitude reduction for the higher order modes of over 60% has been obtained with a tuning current of 5.5 mA. A fundamental mode finesse of approximately 60 is maintained throughout tuning. These tunable cavities have great potential in applications using cavity arrays or requiring dynamic mode control
A HYPOTHESIS RELATING CRITICAL POTASSIUM CONCENTRATIONS FOR GROWTH TO THE DISTRIBUTION AND FUNCTIONS OF THIS ION IN THE PLANT CELL (1984)

S ummary The growth and metabolism of plants in response to different concentrations of tissue K is discussed in relation to current knowledge about the distribution and functions of this ion in plant cells. In the cytoplasm, K has an important role in providing the correct ionic environment for metabolic processes. The ionic requirements of protein synthesis seem to be particularly important in determining the composition of the cytoplasm. Potassium is not replaceable in its cytoplasmic functions and the plant probably needs to maintain the cytoplasmic concentration of K in the range of 100 to 200 mM. Potassium salts in the vacuole are involved in the generation of turgor but when unavailable they can be replaced by other solutes. Salts of other cations such as Na and Mg are often a readily available alternative to K but in their absence organic solutes must be accumulated. With these observations as a basis, a model is proposed in which, as the concentration of K in the tissue declines, the concentration in the cytoplasm is initially maintained constant, while that in the vacuole decreases. In order to maintain turgor, alternative solutes are accumulated in the vacuole as replacements for K. It is assumed that K in the vacuole can only drop to a certain minimum level and, once this is reached, any further decline of tissue K must be at the expense of that in the cytoplasm. This leads to a decrease in the rate of metabolic processes that depend on K and so to a decline in growth. The hypothesis explains the observed relationships between growth and concentrations of K in tissues, and their modification by Na and other cations.
Up to 15km Cavity Self Seeded WDM-PON System with 90km Maximum Reach and up to 4.9Gbit/s CPRI Links (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text F. Saliou, P. Chanclou, B. Charbonnier, B. Le Guyader, Q. Deniel, A. Pizzinat, N. Genay, Z. Xu, and H. Lin, "Up to 15km Cavity Self Seeded WDM-PON System with 90km Maximum Reach and up to 4.9Gbit/s CPRI Links," in European Conference and Exhibition on Optical Communication, OSA Technical Digest (online) (Optica Publishing Group, 2012), paper We.1.B.6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Empowering Light Nodes in Blockchains with Block Summarization (2018)

Blockchains have revolutionized the storage of data in an immutable, transparent and non-centralized way. However, public blockchain systems like the Bitcoin system face a problem of scalability, primarily due to the significant and growing size of its blockchain. This paper introduces a method, termed block summarization, which reduces blockchain storage overhead for systems having transferable transactions. The proposed method allows resource-restricted light nodes to store a form of the blockchain such that it can validate the transactions independently which ultimately reduce dependency on full nodes. This way, we can achieve a middle ground between Simplified Payment Verification (SPV) nodes which can only verify the membership of a transaction in the blockchain, and full nodes with pruning enabled which can only support pruning provided they have an infrastructure of full nodes. We implemented our algorithm for a custom blockchain using Bitcoin blocks and were able to achieve a compression ratio of 0.54.
Coregistering functional near-infrared spectroscopy with underlying cortical areas in infants (2014)

Functional near-infrared spectroscopy (fNIRS) is becoming a popular tool in developmental neuroscience for mapping functional localized brain responses. However, as it cannot provide information about underlying anatomy, researchers have begun to conduct spatial registration of fNIRS channels to cortical anatomy in adults. The current work investigated this issue with infants by coregistering fNIRS and magnetic resonance imaging (MRI) data from 55 individuals. Our findings suggest that fNIRS channels can be reliably registered with regions in the frontal and temporal cortex of infants from 4 to 7 months of age. Although some macro-anatomical regions are difficult to consistently define, others are more stable and fNIRS channels on an age-appropriate MRI template are often consistent with individual infant MRIs. We have generated a standardized scalp surface map of fNIRS channel locators to reliably locate cortical regions for fNIRS developmental researchers. This new map can be used to identify the inferior frontal gyrus, superior temporal sulcus (STS) region [which includes the superior and middle temporal gyri (MTG) nearest to the STS], and MTG and temporal-parietal regions in 4- to 7-month-old infants. Future work will model data for the whole head, taking into account the properties of light transport in tissue, and expanding to different ages across development.
Tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc (2013)

We report the characterization of tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable zinc chelator for intercepting biological mobile zinc. Compared to N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), TPA chelates zinc with faster kinetics in cuvettes, live cells, and brain slices. TPA also is generally less toxic than TPEN in cell culture. Mechanistic analysis indicates that these improvements arise from both the electronic and steric properties of TPA including weaker metal-binding affinity, lower pKa, and smaller size. These results demonstrate that TPA chelation is a valuable addition to the methodologies available for investigating mobile zinc in biology.
Structurally Flexible Triethanolamine Core PAMAM Dendrimers Are Effective Nanovectors for DNA Transfection in Vitro and in Vivo to the Mouse Thymus (2011)

With the aim of developing dendrimer nanovectors with a precisely controlled architecture and flexible structure for DNA transfection, we designed PAMAM dendrimers bearing a triethanolamine (TEA) core, with branching units pointing away from the center to create void spaces, reduce steric congestion, and increase water accessibility for the benefit of DNA delivery. These dendrimers are shown to form stable nanoparticles with DNA, promote cell uptake mainly via macropinocytosis, and act as effective nanovectors for DNA transfection in vitro on epithelial and fibroblast cells and, most importantly, in vivo in the mouse thymus, an exceedingly challenging organ for immune gene therapy. Collectively, these results validate our rational design approach of structurally flexible dendrimers with a chemically defined structure as effective nanovectors for gene delivery, and demonstrate the potential of these dendrimers in intrathymus gene delivery for future applications in immune gene therapy.
Amino acid limitation regulates gene expression (1999)

In mammals, the plasma concentration of amino acids is affected by nutritional or pathological conditions. For example, an alteration in the amino acid profile has been reported when there is a deficiency of any one or more of the essential amino acids, a dietary imbalance of amino acids, or an insufficient intake of protein. We examined the role of amino acid limitation in regulating mammalian gene expression. Depletion of arginine, cystine and all essential amino acids leads to induction of insulin-like growth factor-binding protein-1 (IGFBP-1) mRNA and protein expression in a dose-dependent manner. Moreover, exposure of HepG2 cells to amino acids at a concentration reproducing the amino acid concentration found in portal blood of rats fed on a low-protein diet leads to a significantly higher (P < 0.0002) expression of IGFBP-1. Using CCAAT/enhancer-binding protein homologous protein (CHOP) induction by leucine deprivation as a model, we have characterized the molecular mechanisms involved in the regulation of gene expression by amino acids. We have shown that leucine limitation leads to induction of CHOP mRNA and protein. Elevated mRNA levels result from both an increase in the rate of CHOP transcription and an increase in mRNA stability. We have characterized two elements of the CHOP gene that are essential to the transcriptional activation produced by an amino acid limitation. These findings demonstrate that an amino acid limitation, as occurs during dietary protein deficiency, can induce gene expression. Thus, amino acids by themselves can play, in concert with hormones, an important role in the control of gene expression.
A Blind Watermarking Method with Strong Robust Based on 2D-Barcode (2009)

A watermarking technique based on 2D-barcode and human visual system is proposed. A structured 2D-barcode, PDF417, is used as watermark . In order to reduce the inserting watermark data, the 2D-barcode is preprocessed before inserted through omitting border of barcode, heading and ending characters , reducing barcodepsilas modules and scrambling the watermark based on chaotic sequence. A mask of the source image is modulated based on wavelet transform and a best region is chosen by using the human visual system performance. It is a blind watermarking system because the extraction and detection are independent on any original information in prior of inserting operation, restoring the heading and ending characters of the barcode. This technique enhanced the robust through watermark structure and embedding algorithm, which strengthens the resistance for different attacks.
Effects of Turbulence on Signal Intensity in Gradient Echo Images (1988)

Although the appearance of laminar vascular flow in magnetic resonance (MR) images has been characterized, there is no general agreement about the effect of turbulent flow on MR signal intensity. This study uses a fast scan gradient echo pulse sequence to evaluate nonpulsatile turbulent flow in two different models. The first model simulated flow in normal vascular structure. It generated nonpulsatile, laminar and turbulent flow in straight, smooth-walled Plexiglas tubes. The second model simulated flow through a vascular stenosis. It generated nonpulsatile, laminar, and turbulent flow through an orifice. Velocities and flow rates ranged from low physiologic to well above the physiologic range (velocity = .3 to 280 cm/second, flow rate from .15 to 40 L/minute). Transition from laminar to turbulent flow was observed with dye streams. Turbulent flow in straight, smooth-walled vessels was not associated with a decrease in MR signal intensity even at the highest velocities and flow rates studied. The transition from laminar to turbulent flow through an orifice is not associated with a decrease in gradient echo signal intensity. As the intensity of the turbulent flow increases, however, there is a threshold above which signal intensity decreases linearly as turbulence increases (r = .97). This study suggests that flow in normal vascular structures should not be associated with decreased signal intensity in gradient echo images. Turbulent flow through areas such as valves, valvular lesions or vascular stenoses, may be associated with a decrease in gradient echo signal intensity.
Hollow Carbon Nanospheres with Superior Rate Capability for Sodium‐Based Batteries (2012)

Hollow carbon nanospheres are synthesized via the hydrothermal carbonization of glucose in the presence of nanosized latexes templates. The resulting disordered carbon hollow nanospheres exhibits excellent characteristics in terms of reversible capacities, cycling performance, and rate capability for application as an anode material in Na-based batteries.
Fat in Swine Nutrition (2000)

I. Introduction .............................................................................................................................95 II. Physical and Chemical Properties ..........................................................................................95 III. Fat Quality...............................................................................................................................98 IV. Specific Uses of Fat ................................................................................................................99 V. Biological Effects..................................................................................................................100 VI. Overview of the Pathways of Lipid Metabolism .................................................................101 VII. Effects of Fat on Performance..............................................................................................101 References ......................................................................................................................................103In the previous edition of this book, Pettigrew and Moser (1991) emphasized the effects of dietary fat on performance of pigs at various stages of production. These observations are still of relevance to swine nutrition and are summarized below. In addition, research related to use of fat in swine nutrition published since the first edition is emphasized.