gebhart/patrepeval huggingface dataset:
4-(1-Adamantyl)phenylalkylamines with Potential Antiproliferative Activity (2016)

Background: In our previous publications we have described the synthesis of aminosubstituded diaryl adamantanes and their pharmacological evaluation in vitro and in vivo against many cancer cell lines. More recently, we have reported the synthesis of mono C2-aryl substituted aminoadamantane derivatives that have moderate antiproliferative activity at low micromolar IC50 against a panel of four tumor cell lines. Methods: The synthesis and the pharmacological evaluation of 4-(1-adamantyl) phenylalkylamines 1-4 is described in this work. The new derivatives present an aryl substitution at C-1 adamantane position and diverge from the methylene spacer between the phenyl ring and the amine heterocycle moiety. Results: Piperazines 1a (R:N-H) and 1b (R:N-Me) are more active than piperidine 1c. This difference indicates the importance of the presence of this nitrogen atom in 1a and 1b, which is at a distance of 3 atoms (two carbons and the piperazine nitrogen included) from the benzene ring. Adducts 2a,b are less active than the rest of the products, because neither the R:N-H nitrogen atom (compound 2a) nor the R:N-Me nitrogen (compound 2b) are in an optimum distance from the benzene ring. Derivatives 3a-c are almost as potent as the piperazines 1a and 1b, which means that also in this case, the distance of 2 atoms (PhβCH2αCH2N) is sufficient for antiproliferative activity. Products 4a-c have also significant activity, possibly due to the fact that the benzene moiety is attached to the nitrogen atom via a three methylene linker. Piperidine 4c is the most potent compound, showing that the nitrogen atom of these cyclic amines, which is near to benzene ring, is important for the pharmacological action. Conclusion: The comparison of the pharmacological results of the present work in relation to our previous publication shows that C-1 substitution in adamantane skeleton with aminoaryl or aminoalkyl groups enhances the antiproliferative activity towards to C-2 substitution. Our approach shows that the optimization of the antiproliferative activity is the incorporation of the p-aminoalkylphenyl side chain at C-1 adamantane position. Keywords: Antiproliferative evaluation, C-1 adamantyl substitution, phenylakylamines, synthesis.
A Fuzzy Support Vector Machine with Weighted Margin for Flight Delay Early Warning (2008)

Flight delay early warning can reduce the negative impact of the delay. Determining the delay grade of each interval is essentially a multi-class classification problem. This paper presents a flight delay early warning model based on a fuzzy support vector machine with weighted margin (WMSVM) , which adjust the penalties to samples and the margins between samples and the hyperplane according to the fuzzy membership to produce a more reasonable optimal hyperplane. Through one-against-one (OAO) method, the original FSVM is extended to solve multi-class classification problem .Experiments show that the method used to establish the early warning model can predict the delay grade effectively and also prove that the OAO-WMSVM has better performance than OAO-SVM.
Tailoring Multiphase Ceramics. (1985)

Abstract : The Tailoring Multiphase Ceramics Conference emphasized the discussion and analysis of the properties of multiphase ceramic materials in which the microstructure is deliberately tailored for specific applications or properties. A number of internationally recognized authorities presented keynote and invited lectures on topics dealing with processing and fabrication of multiphase and composite ceramics, multiphase electroceramics, fiber and whisker reinforced composites, and high temperature multiphase ceramics. The results of recent research were presented in oral and poster sessions by leading researchers from several countries. (Author)
Influence of Side-Chain Length on the Gas Permeation Properties of Poly(2-alkylacetylenes) (2004)

The pure-gas permeation properties for a systematic series of disubstituted, amorphous, glassy poly(2-alkylacetylenes), i.e., poly(2-hexyne), poly(2-octyne), poly(2-nonyne), poly(2-decyne), and poly(2-undecyne), were determined at 35 °C for H2, CO2, O2, N2, CH4, C2H6, C3H8, and n-C4H10. Gas permeability increased by increasing the (i) side-chain length of the polymers and (ii) size and condensability of the penetrants. For example, the nitrogen and n-butane permeabilities of poly(2-undecyne) were 2- and 10-fold higher than those of poly(2-hexyne). As the fractional free volume decreases with increased side-chain length, the permeability increases. This behavior is opposite to that observed in polyacetylenes containing terminal bulky side-group substituents, such as trimethylsilyl or isopropyl groups. In branched acetylene-based polymers, the gas permeation properties correlate well with their free volume values; as fractional free volume increases, a simultaneous increase in permeability is observed. In linear poly(2-alkylacetylenes), an increase in side-chain length increases the overall chain mobility and increases the chain packing density of the polymers. In mixed-gas permeation experiments, an increase in mixed-gas n-butane permeability and n-butane/methane selectivity was observed with increasing side-chain length of poly(2-alkylacetylenes).
Outer Wall Selectively Oxidized, Water-Soluble Double-Walled Carbon Nanotubes (2010)

The outer walls of double-walled carbon nanotubes (DWNTs) were selectively oxidized using a combination of oleum and nitric acid. Intercalation of oleum between bundled DWNTs enabled a homogeneous reaction by equally exposing all outer wall surfaces to the oxidants. At optimized reaction conditions, this double-wall chemistry enabled high water solubility through carboxylic acid functional groups introduced to the outer wall, while leaving the inner tube intact, as shown by Raman scattering and high resolution TEM. These outer wall selectively oxidized DWNTs retained electrical conductivity up to 65% better than thin films of similarly functionalized single-walled carbon nanotubes, which can be attributed to enhanced electrical percolation via the nonoxidized inner tubes.
Thread Segmentation Based Answer Detection in Chinese Online Forums (2014)

摘要: 在论坛话题中识别答案是面向论坛的问答对挖掘中的核心问题. 在论坛话题的讨论中通常存在隐式的结构, 这种结构信息非常有助于最佳答案的定位和识别. 本文提出了一种基于中文论坛话题段落划分的答案识别方法: 首先将论坛话题重新组织为若干段落的集合, 并基于此划分提取一组能够反映话题讨论逻辑结构的特征. 在此基础上给出了一种可以根据候选答案所在段落类别实现模型选择的答案识别策略, 从而避免了噪声信息对模型预测的误导. 实验结果表明本文的答案识别方法非常适用于面向在线论坛的问答资源挖掘工作. 关键词: 话题段落划分 / 非文本特征 / 答案识别 / 在线论坛 / 问答对挖掘
The Mass Spectrometer (2007)

This chapter contains sections titled: Introduction Ion Guides Types of m/z Analyzers Calibration of the m/z Scale Ion Detectors Vacuum Systems References
Application of Synchrotron Radiation X-Ray Microtomography to Nondestructive Evaluation of Thermal Fatigue Process in Flip Chip Interconnects (2011)

New nondestructive inspection methods with high spatial resolution are expected to support the evaluation and enhancement of the reliability of microjoints on printed circuit boards. An X-ray microtomography system, the SP-μCT has been developed at the Super Photon ring-8 GeV (SPring-8), the largest synchrotron radiation facility in Japan. In this work, the SP-μCT was first applied to the nondestructive evaluation of thermal fatigue phenomena, namely microstructure evolution (i.e., phase growth) and microcrack propagation, appearing in actual solder microbumps of flip chip interconnects due to thermal cyclic loading. In addition, a refraction-contrast imaging technique was simultaneously applied to visualize the fatigue cracks with an actual opening of less than 100 nm. The observed specimen has a flip chip structure joined by Sn-37wt%Pb eutectic solder bumps 150 μm in diameter. Consequently, the process of phase growth and crack propagation was determined via observation of consecutive computed tomography (CT) images obtained in the same plane of the same specimen. As the thermal cycle proceeded, remarkable phase growth was clearly observed, followed by the appearance of fatigue cracks in the corners of the interfaces between the solder bump and Cu pad. Moreover, the CT images also enabled us to evaluate the fatigue lifetime of the bumps, as follows. The lifetime to fatigue crack initiation was estimated by quantifying the increase in the phase growth. The crack propagation lifetime to failure was then determined by measuring the average crack propagation rate. Such results have not been obtainable at all by X-ray CT systems for industrial use and demonstrate the possibility of nondestructive inspection by a synchrotron radiation X-ray microtomography system.
Structure of Aqueous Solutions of Acetonitrile Investigated by Acoustic and Positron Annihilation Measurements (2005)

We report the results of acoustic and positron annihilation measurements in aqueous solutions of acetonitrile (CH 3 CN). Hydrophobicity of the solute is discussed, as well as the possibility of describing the title system in terms of hydrophobic solvation. The concept of Levay et al. of calculating the "ideal" positronium lifetimes is applied, basing on the mean volume of cavities (holes) in liquid structure available for positronium pseudoatom. The same calculations performed using the Tao model of annihilation yield very different results. It can be concluded that either acetonitrile forms with water clathrate-like hydrates of untypical architecture, or it is too weak hydrophobic agent to form clathrate-like hydrates at all. The former interpretation seems to be more probable.
DOMESTICATION STUDIES OF MATICO (BUDDLEJA GLOBOSA HOPE) (2002)

ISHS International Conference on Medicinal and Aromatic Plants. Possibilities and Limitations of Medicinal and Aromatic Plant Production in the 21st Century DOMESTICATION STUDIES OF MATICO (BUDDLEJA GLOBOSA HOPE)
Suppression of ICAM-1 in human venous endothelial cells by small interfering RNAs (2005)

This is the first report that ICAM-1 expression can be effectively silenced by siRNAs on endothelial cells from human saphenous veins. This new technology may render novel therapeutic concepts to reduce early graft failure by protecting venous bypass grafts against early intra- or postoperative leukocyte infiltration.
Purification de l'invertase de levure (1951)

Abstract Une purification de l'invertase de levure de boulangerie est décrite.
Early Capacity Testing of an Enterprise Service Bus (2006)

An enterprise service-oriented architecture is typically realized on a messaging infrastructure called an enterprise service bus (ESB). An ESB is a bus which delivers messages from service requesters to service providers. Since it sits between the service requesters and providers, it is not appropriate to use any existing capacity planning methodology for servers, such as modeling to estimate an ESB's capacity. There are programs which run on an ESB called mediation modules. Their functionalities vary and depend on how people use the ESB. This creates difficulties for capacity planning and performance evaluation. This paper proposes a performance evaluation methodology and techniques for ESBs. We actually run the ESB on a real machine while providing a pseudo-environment around it. In order to ease setting up the environment we provide ultra-light service requestors and service providers for the ESB under test. We show that the proposed mock environment can be set up with practical hardware resources available at the time of hardware resource assessment. Our experimental results showed that the testing results with our mock environment are equivalent to the results in the real environment
Grundlagen des Rationalitätssicherungsansatzes (2002)

Weber und Schäffer weisen dem Controlling die Funktion der Sicherstellung von Rationalität der Unternehmensführung zu.1 Diese Definition der Funktion als Sicherstellung von Rationalität der Unternehmensführung korrespondiert mit den von den Controllern in der Praxis im Zusammenspiel mit den Managern wahrgenommenen Tätigkeiten2 in der Informationsversorgung, der Planung und der Kontrolle.3 Sehr deutlich wird der Beitrag der Controller zu dieser Funktion der Sicherstellung von Rationalität, wenn diese die Rolle eines Sparringpartners oder einer „contre rôle“ einnehmen und mit dem Management in einen kritischen Diskurs über Entscheidungsinhalte treten.4
Genetic Code Ambiguity Confers a Selective Advantage on <i>Acinetobacter baylyi</i> (2007)

A primitive genetic code, composed of a smaller set of amino acids, may have expanded via recursive periods of genetic code ambiguity that were followed by specificity. Here we model a step in this process by showing how genetic code ambiguity could result in an enhanced growth rate in Acinetobacter baylyi.
Geminal fluorination of diazo compounds (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeminal fluorination of diazo compoundsTimothy B. Patrick, Jeffrey J. Scheibel, and Gary L. CantrellCite this: J. Org. Chem. 1981, 46, 19, 3917–3918Publication Date (Print):September 1, 1981Publication History Published online1 May 2002Published inissue 1 September 1981https://pubs.acs.org/doi/10.1021/jo00332a034https://doi.org/10.1021/jo00332a034research-articleACS PublicationsRequest reuse permissionsArticle Views1393Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Noninvasive, Quantitative Assessment of Liver Fat by MRI‐PDFF as an Endpoint in NASH Trials (2018)

Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease worldwide, and the progressive form of this condition, nonalcoholic steatohepatitis (NASH), has become one of the leading indications for liver transplantation. Despite intensive investigations, there are currently no United States Food and Drug Administration-approved therapies for treating NASH. A major barrier for drug development in NASH is that treatment response assessment continues to require liver biopsy, which is invasive and interpreted subjectively. Therefore, there is a major unmet need for developing noninvasive, objective, and quantitative biomarkers for diagnosis and assessment of treatment response. Emerging data support the use of magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF) as a noninvasive, quantitative, and accurate measure of liver fat content to assess treatment response in early-phase NASH trials. In this review, we discuss the role and utility, including potential sample size reduction, of MRI-PDFF as a quantitative and noninvasive imaging-based biomarker in early-phase NASH trials. Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease worldwide.<sup>(</sup><sup>)</sup> NAFLD can be broadly classified into two categories: nonalcoholic fatty liver, which has a minimal risk of progression to cirrhosis, and nonalcoholic steatohepatitis (NASH), the more progressive form of NAFLD, which has a significantly increased risk of progression to cirrhosis.<sup>(</sup><sup>)</sup> Over the past two decades, NASH-related cirrhosis has become the second leading indication for liver transplantation in the United States.<sup>(</sup><sup>)</sup> For these reasons, pharmacological therapy for NASH is needed urgently. Despite intensive investigations, there are currently no therapies for treating NASH that have been approved by the United States Food and Drug Administration.<sup>(</sup><sup>)</sup>.
Introduction to materials science for engineers (1985)

Accompanying CD-ROM contains ... "materials science software, image and video galleries, articles, solutions to practice problems, links to societies and schools, and supplemental materials." -- disc label.
Several-hours-ahead electricity price and load forecasting using neural networks (2005)

In daily power markets, forecasting electricity prices and loads are the most essential task and basis for any decision making. An approach to predict the market behaviors is to use the historical prices, loads and other required information to forecast the future prices and loads. This paper introduces an approach for several-hours-ahead electricity price and load forecasting using artificial intelligence method, such as neural network model, which uses publicly available data from NEMMCO web site to forecast electricity prices and loads for the Victorian electricity market. An approach of selection of similar days is proposed according to which the load and price curves are forecasted by using the information of the days being similar to that of the forecast day. A Euclidean norm with weighted factors is used for the selection of similar days. Two different ANN models, one for several-hours-ahead load forecasting and another for several-hours-ahead price forecasting have been proposed. The forecasted price and load from the neural network is obtained by adding a correction to the selected similar days, and the correction is obtained from the neural network. MAPE results show that several-hours-ahead electricity price and load in the deregulated Victorian market can be forecasted with reasonable accuracy.
High-power cw Raman fiber laser using phosphosilicate fiber pumped by Yb-doped double-clad fiber laser (2001)

A high-power Raman fiber laser (RFL) with maximum output power of 4.11 W/1239 nm and 2.24 W/1484 nm is obtained using a continuous wave (CW) 8.4 W/1064 nm Yb-doped double-clad fiber laser (DCFL) as a pump, phosphorous-doped fiber (PDF) and cascaded cavities made with fiber Bragg Gratings (FBG). RFL performance for the 300, 700 and 1150 m PDF lengths and output mirror reflectance was experimentally investigated by observing maximum output power, slope efficiency, threshold power, and full-width at half maximum at both the first and second Stokes wavelength.
A fully implemented 12 /spl times/ 12 data vortex optical packet switching interconnection network (2005)

A fully functional optical packet switching (OPS) interconnection network based on the data vortex architecture is presented. The photonic switching fabric uniquely capitalizes on the enormous bandwidth advantage of wavelength division multiplexing (WDM) wavelength parallelism while delivering minimal packet transit latency. Utilizing semiconductor optical amplifier (SOA)-based switching nodes and conventional fiber-optic technology, the 12-port system exhibits a capacity of nearly 1 Tb/s. Optical packets containing an eight-wavelength WDM payload with 10 Gb/s per wavelength are routed successfully to all 12 ports while maintaining a bit error rate (BER) of 10/sup -12/ or better. Median port-to-port latencies of 110 ns are achieved with a distributed deflection routing network that resolves packet contention on-the-fly without the use of optical buffers and maintains the entire payload path in the optical domain.
Potent and Selective Inhibitors of Platelet-Derived Growth Factor Receptor Phosphorylation. 3. Replacement of Quinazoline Moiety and Improvement of Metabolic Polymorphism of 4-[4-(<i>N</i>-Substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline Derivatives (2003)

We have previously reported that a series of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives were potent and selective inhibitors of platelet-derived growth factor receptor (PDGFR) phosphorylation and demonstrated several biological effects such as suppression of neointima formation following balloon injury in rat carotid artery by oral administration. Here, we investigated structure-activity relationships of the 6,7-dimethoxyquinazolinyl moiety. In regard to 6,7-dimethoxy groups, ethoxy analogues showed potent activity (IC(50) of 16b is 0.04 microM; IC(50) of 17a is 0.01 microM) and further extension of the alkyl group reduced activity. Interestingly, methoxyethoxy (IC(50) of 16j is 0.02 microM; IC(50) of 17h is 0.01 microM) and ethoxyethoxy (IC(50) of 17j is 0.02 micro M) analogues showed the most potent activity, suggesting that the inserted oxygen atom significantly interacts with beta-PDGFR. Among tricyclic quinazoline derivatives, the 2-oxoimidazo[4,5-e]quinazoline derivative 21a showed potent activity (IC(50) = 0.10 microM). Regarding replacements of quinazoline by other heterocyclic rings, pyrazolo[3,4-d]pyrimidine (39a, IC(50) = 0.17 microM) and quinoline (IC(50) of 40a is 0.18 microM; IC(50) of 40b is 0.09 microM) derivatives showed potent activity. Isoquinoline and some pyridopyrimidine derivatives were completely inactive; therefore, 1-aza has an important role. Also 7-aza and 8-aza substitution on the parent quinazoline ring has a detrimental effect on the interaction with beta-PDGFR. We also demonstrated that the substituents on the quinazoline ring possess major consequences for metabolic polymorphism. Although there existed extensive metabolizers and poor metabolizers in Sprague-Dawley rats administrated 6,7-dimethoxyquinazoline derivatives (1b and 1c), 6-(2-methoxy)ethoxy-7-methoxyquinazoline analogue 16k showed no metabolic polymorphism.
The 3' portion of the gene for a Plasmodium yoelii merozoite surface antigen encodes the epitope recognized by a protective monoclonal antibody. (1988)

The 230-kDa merozoite antigen of the murine malarial parasite Plasmodium yoelii provides a potential model system for the development of a protective erythrocytic stage vaccine. To characterize this antigen at the molecular level, isolated P. yoelii 17XL DNA was used to construct a genomic library in the expression vector lambda gt11. A monoclonal antibody, mAb 302, which passively protected mice against P. yoelii challenge infection, was used to identify a lambda gt11 recombinant clone encoding a portion of the 230-kDa antigen of this parasite. Using this clone as a probe, we identified an mRNA of 7.6 kilobases by RNA blot analysis. Nucleic acid sequence analysis of the clone showed that the epitope recognized by the protective mAb 302 is encoded by the 3' portion of the gene for the 230-kDa antigen. The deduced amino acid sequence revealed that this antigen also contains the tandemly repeated tetrapeptide Gly-Ala-Val-Pro, a series of 10 cysteine residues located within the terminal 110 amino acids, and a potential membrane anchor of 18 hydrophobic residues. Comparison of this C-terminal sequence with the carboxyl segment of the 195-kDa merozoite antigen of Plasmodium falciparum revealed nucleic acid and amino acid sequence similarities ranging from 40% to 70%. The localization of a B-cell epitope recognized by the protective mAb 302 to this carboxyl region of the P. yoelii antigen, combined with the limited strain variability in this region of the homologous 195-kDa antigen of P. falciparum, has implications for the development of an effective erythrocytic stage malarial vaccine.