gebhart/patrepeval huggingface dataset:
Sulfonation and Sulfation (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfonation and SulfationEverett E. Gilbert and E. Paul JonesCite this: Ind. Eng. Chem. 1953, 45, 9, 2041–2064Publication Date (Print):September 1, 1953Publication History Published online1 May 2002Published inissue 1 September 1953https://pubs.acs.org/doi/10.1021/ie50525a039https://doi.org/10.1021/ie50525a039research-articleACS PublicationsRequest reuse permissionsArticle Views602Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Heterostructuring Nanocrystal Quantum Dots Toward Intentional Suppression of Blinking and Auger Recombination (2013)

At the level of a single particle, nanocrystal quantum dots (NQDs) are observed to fluoresce intermittently or "blink." They are also characterized by an efficient non-radiative recombination process known as Auger Recombination (AR). Recently, new approaches to NQD heterostructuring have been developed that directly impact both blinking and AR, resulting in dramatic suppression of these unwanted processes. The three successful hetero-NQD motifs are reviewed here: (1) interfacial alloying, (2) thick or "giant" shells, and (3) specific type-II electronic structures. These approaches, which rely on modifying or tuning internal NQD core/shell structures, are compared with alternative strategies for blinking suppression that rely, instead, on surface modifications or surface-mediated interactions. Finally, in each case, the unique synthetic approaches or challenges addressed that have driven the realization of novel and important functionality are discussed, along with the implications for development of a comprehensive 'materials design' strategy for blinking and AR-suppressed heterostructured NQDs.
Synthesis of antibiotic‐loaded hydroxyapatite beads and <i>in vitro</i> drug release testing (1992)

Various forms of hydroxyapatite (HAP) materials have been developed for use as bone grafts. Since the risk of local infection is associated with surgery, it seems reasonable to incorporate drugs such as antibiotics into implant materials. We therefore investigated the characteristics of drug incorporation into a spherical porous HAP bead (diameter = 8.48 mm, bulk porosity = 0.439) and its in vitro release behavior. Cefotiam (CTM) was used as a model antibiotic. Because of nonuniform pore distribution in the bead, distribution of CTM was estimated from the amounts of CTM experimentally determined at three different sites: the surface, halfway to the center, and the center of the beads. The results indicated that 90% of the drug was incorporated in the concentric outer 0.387 (radius = 1) section of the bead. CTM was released with a short lag time when the dry HAP bead was placed in water. Incorporation of CTM with egg phosphatidylcholine eliminated initial lag time and decreased the release rate of the drug from the bead. The lipid load was useful in controlling the release of CTM from the beads. In addition, to protect relatively unstable drugs from humidity and avoid contamination of drug-incorporated HAP beads an apparatus was designed with which the beads could be enclosed in vials in vacuo and under aseptic conditions on a bench-scale basis.
Full-wave computed tomography. Part 2: Resolution limits (1984)

Invoking our recently developed exact inverse theory, we derive limits on the resolution of individual spatial frequency components of a reconstructed image, set by imperfections of measurement. These are minimum limits, only achievable when one knows how to invert data without adulterating the underlying theory with strong assumptions (sweeping approximations are implicit in most practical inversion algorithms). Resolution limits on imaging with conservative fields are also derived, but (recognising the physical constraints on the formation of useful images) for situations simple enough that data inversion is easily effected without introducing approximations.
Distributed network protocols for wireless communication (2002)

This paper describes a network design strategy that focuses on energy conservation. This position-based network protocol is optimized for minimum energy consumption in wireless networks that support peer-to-peer communication. Given any number of randomly deployed communication nodes over an area, we show that a simple local optimization scheme executed at each node guarantees strong connectivity of the entire network and attains the global minimum energy solution for both stationary and mobile networks.
Diffusion creep in ceramics (1999)

At sufficiently low stresses, where intragranular dislocation mobility is rather limited, plastic deformation can occur solely by the diffusion of vacancies either through the matrix (Nabarro-Herring) or along grain boundaries (Coble). The process of diffusion creep has been modelled theoretically for over 50 years now, although there still remain some doubts over the experimental validation of the models. It has been suggested that low intragranular dislocation mobility leads to more frequent observations of diffusion creep in ceramics compared to metals. In ceramics, the diffusion creep process is more complex than in metals due to the need to account for charge balance and the transport of two or more ionic species along two different paths (lattice or grain boundary). The report critically evaluates the experimental observations of diffusion creep in some oxide-based ceramic systems. In addition, the process of ambipolar diffusion in ceramics is examined with two different considerations: (a) the total flux to grain boundaries is in the appropriate stoichiometric ratio, so that the cations and anions may be transported along different paths, and (b) the flux along each transport path is in the appropriate stoichiometric ratio. It is demonstrated that the above two considerations lead to substantially different predictions on rate controlling processes
"NOFUS: Automatically Detecting" + String.fromCharCode(32) + "ObFuSCateD ".toLowerCase() + "JavaScript Code" (2011)

Obfuscation is applied to large quantities of benign and malicious JavaScript throughout the web. In situations where JavaScript source code is being submitted for widespread use, such as in a gallery of browser extensions (e.g., Firefox), it is valuable to require that the code submitted is not obfuscated and to check for that property. In this paper, we describe NoFus, a static, automatic classifier that distinguishes obfuscated and non-obfuscated JavaScript with high precision. Using a collection of examples of both obfuscated and non-obfuscated JavaScript, we train NoFus to distinguish between the two and show that the classifier has both a low false positive rate (about 1%) and low false negative rate (about 5%). Applying NoFus to collections of deployed JavaScript, we show it correctly identifies obfuscated JavaScript files from Alexa top 50 websites. While prior work conflates obfuscation with maliciousness (assuming that detecting obfuscation implies maliciousness), we show that the correlation is weak. Yes, much malware is hidden using obfuscation, but so is benign JavaScript. Further, applying NoFus to known JavaScript malware, we show our classifier finds 15% of the files are unobfuscated, showing that not all malware is obfuscated.
Significance of the cyclic structure and of arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes (2009)

Arenicin-1 (Ar-1) is a beta-sheeted antimicrobial peptide from the marine lugworm Arenicola marina. To elucidate the significance of its unique 18-residue cyclic structure and of six cationic arginines for its biological activity and its interaction with biomembranes, we synthesized one linear peptide in which the two cysteines were exchanged for serines (C/S-Ar-1) and a cyclic peptide in which all arginines were replaced by lysines (R/K-Ar-1). We addressed antibacterial and hemolytic activities, the impact of the peptides on bacterial morphology, and their binding to, intercalation into, and permeabilization of model membranes composed of phospholipids or lipopolysaccharide (LPS). In accordance with high salt concentration in sea water, the antibacterial activity of Ar-1 was almost insensitive to high NaCl concentrations. In contrast, the linear derivative lost activity under these conditions against polymyxin B-resistant Proteus mirabilis. Ar-1 intercalated into phospholipid and LPS membranes and formed heterogeneous and short-lived lesions. However, when the peptide was present in both membrane leaflets, it formed defined pores. This characteristic was not observed for the linear derivative C/S-Ar-1. Apparently, the disulfide bond provides conforma-tional stability, which has an impact on salt tolerance, prevents fast degradation by trypsin, and is a prerequisite for the formation of structurally defined pores.
59 A PRELIMINARY STUDY OF THE IN VITRO DEVELOPMENT OF ASIAN ELEPHANT, CLONED EMBRYOS, RECONSTRUCTED USING A RABBIT RECIPIENT OOCYTE (2004)

Interspecies nuclear transfer is an important tool for studying the interaction between the cytoplasm of one cell and the donor nucleus of another (Chen et al. 2002 Biol. Reprod. 67, 637–642). The aim of this experiment was to investigate the possibility of developing in vitro an asian elephant cloned embryo using a rabbit recipient oocyte. The elephant donor cells were obtained from the ear skin of a stillborn Asian elephant (Elephus maximus) and the in vivo-matured recipient oocytes were obtained from FSH-stimulated New Zealand White doe rabbits. Enucleation was accomplished by aspiration of the first polar body and the metaphase II plate together with a small amount of cytoplasm. Successful enucleation was confirmed by UV examination after staining with 5 µg mL-1 Hoechst 33342. The donor cells were introduced into the perivitelline space of the enucleated oocytes immediately after enucleation. The elephant-rabbit reconstructed embryos were fused in 0.3 M manitol with 0.1 mM Ca2+ and Mg2+ using two types of electrical pulses: E1 (n = 61): 3.2 kV/cm, 3 pulses, 20 µs (Chesne et al. 2002 Nat. Biotechnol. 20, 366–369); E2 (n = 69): 2.0 kV/cm, 2 pulses, 20 µs (Chen et al. 2002 Biol. Reprod. 67, 637–642). The fused embryos were activated 1 h after fusion by electrical pulses to those used for fusion and then incubated in 5 µg mL-1 cyclohexamide and 2 mM 6-DMAP for 1 h. Subsequently, the activated embryos were cultured in B2 medium containing 2.5% fetal calf serum. The developmental rate was observed every 24 h for 7 days and the differences in the percentages of embryos developing to a particular stage were determined by chi-square analysis. The results showed that the fusion and cleavage rates of elephant-rabbit cloned embryos fused and activated by E1 were significantly higher than for E2 (P &lt; 0.05; see Table 1). Compared with rabbit-rabbit cloned embryos using adult skin fibroblast as a donor cell and E1 for both fusion and electrical activation, we found that the cleavage and blastocyst rates of elephant-rabbit cloned embryos was higher than for the rabbit-rabbit ones (65% (28/43) versus 58% (28/48) and 7% (3/43) versus 4% (2/48) respectively). Results from this study showed that either of the electrical pulses, 3.2 kV/cm, 3 pulses, 20 µs or 2.0 kV/cm, 2 pulses, 20 µs, can be used to fuse elephant somatic cells to rabbit ooplasm and the rabbit oocytes can be served as recipient oocytes to support the development of elephant cloned embryos up to the blastocyst stage. Table 1. Developmental rate of elephant–rabbit cloned embryos after being fused by different electrical pulses This work was supported by Rajadapisek Sompoj Fund, Chulalongkorn University.
Competitive antagonists discriminate between NK<sub>2</sub>tachykinin receptor subtypes (1990)

1. We have compared the ability of various tachykinins and selective tachykinin receptor agonists to induce contraction of the endothelium-denuded rabbit pulmonary artery (RPA) and hamster trachea (HT) and have estimated the affinity of some newly developed NK2 selective antagonists in the same tissues. 2. In confirmation of previous findings, experiments with the agonists indicated that NK2 receptors are the main if not the sole mediators of the response to tachykinins in both RPA and HT. No evidence for significant degradation of neurokinin A (NKA) was found in either tissue when experiments were repeated in the presence of a mixture of peptidase inhibitors (thiorphan, captopril and bestatin, 1 microM each). 3. The peptide antagonists tested were: Peptide I = [Tyr5, D-Trp6,8,9, Arg10]-NKA(4-10); Peptide II = [Tyr5, D-Trp6,8,9, Arg10]-NKA(3-10); Peptide III = Ac-Leu-Asp-Gln-Trp-Phe-Gly-NH2. The three peptides produced a concentration-dependent rightward shift of the concentration-response curve to NKA in both RPA and HT with no significant depression of the maximal response attainable. The slopes of the Schild plots were not significantly different from unity, indicating a competitive antagonism. Peptides I and II were about 100 times more potent in the RPA than in the HT, while Peptide III was about 100 times more potent in the HT than RPA. 4. The pA2 values obtained in these two tissues with the three antagonists were not significantly different when tested in the absence or presence of peptidase inhibitors, or when a selective NK2 receptor agonist, [beta Ala8]-NKA(4-10) was used instead of NKA. Similar pA2 values were obtained after 15 or 90min of incubation with the antagonists. Peptides I, II and III had no inhibitory effect on contractions produced by noradrenaline in the RPA or by carbachol in the HT. 5. Peptides I, II and III showed weak or no antagonistic activity toward the vasodilatator effect of substance P in the dog carotid artery (NK, receptor-mediated) or toward the contractile effect of neurokinin B in the rat portal vein (NK3 receptor-mediated). 6. These results provide pharmacological evidence for heterogeneity of NK2 receptors in the RPA and HT. The NK2 receptors present in these tissues are not discriminated by natural tachykinins or selective agonists, but are recognized with very different affinity by NK2 receptor antagonists.
Reliability Failures in Small Optocoupling and DC/DC Converter Devices (2006)

In power electronics, often control and power part are at different electric potentials. Thus, electrically isolated coupling of them is performed by optocoupling devices. Also, isolating DC/DC converters are in use. While such systems are dedicated for high reliability application, weak points within these small components generate problems to the system reliability. The paper outlines most common weakness, as optocoupling internal LEDs, packaging problems and hybrid components in use at their electrical limits
Investigation of the isoplanatic patch and wavefront aberration along the pupillary axis compared to the line of sight in the eye (2012)

Conventional optical systems usually provide best image quality on axis, while showing unavoidable gradual decrease in image quality towards the periphery of the field. The optical system of the human eye is not an exception. Within a limiting boundary the image quality can be considered invariant with field angle, and this region is known as the isoplanatic patch. We investigate the isoplanatic patch of eight healthy eyes and measure the wavefront aberration along the pupillary axis compared to the line of sight. The results are used to discuss methods of ocular aberration correction in wide-field retinal imaging with particular application to multi-conjugate adaptive optics systems.
Antioxidant Mechanisms of Enzymatic Hydrolysates of β-Lactoglobulin in Food Lipid Dispersions (2006)

The antioxidant activities of aqueous phase beta-lactoglobulin (beta-Lg) and its chymotryptic hydrolysates (CTH) were compared in this study. Proteins and peptides have been shown to inhibit lipid oxidation reactions in oil-in-water emulsions; however, a more fundamental understanding of the antioxidant activity of these compounds in dispersed food lipid systems is lacking. CTH was more effective than an equivalent concentration of beta-Lg in retarding lipid oxidation reactions when dispersed in the continuous phase of Brij-stabilized oil-in-water emulsions (pH 7). Furthermore, it was observed that CTH had higher peroxyl radical scavenging and iron-binding values than beta-Lg. Liquid chromatography-mass spectrometry (LC-MS) was used to measure the rate of oxidation of three oxidatively labile amino acid residues (Tyr, Met, and Phe) in certain CTH peptide fragments. Significant oxidation of specific Tyr and Met residues present in two separate 12 amino acid peptide fragments was observed in the days preceding lipid oxidation (39 and 55% of Tyr and Met were oxidized, respectively, by day 4 of the study); however, no significant oxidation of the Phe residue present in a specific 14 amino acid peptide fragment could be observed during the same time period. These data could suggest that Met and Tyr residues are capable of scavenging radical species and have the potential to improve the oxidative stability dispersed food lipids.
Multiparametric MRI of prostate cancer: An update on state‐of‐the‐art techniques and their performance in detecting and localizing prostate cancer (2013)

Magnetic resonance (MR) examinations of men with prostate cancer are most commonly performed for detecting, characterizing, and staging the extent of disease to best determine diagnostic or treatment strategies, which range from biopsy guidance to active surveillance to radical prostatectomy. Given both the exam's importance to individual treatment plans and the time constraints present for its operation at most institutions, it is essential to perform the study effectively and efficiently. This article reviews the most commonly employed modern techniques for prostate cancer MR examinations, exploring the relevant signal characteristics from the different methods discussed and relating them to intrinsic prostate tissue properties. Also, a review of recent articles using these methods to enhance clinical interpretation and assess clinical performance is provided. J. Magn. Reson. Imaging 2013;37:1035-1054. © 2013 Wiley Periodicals, Inc.
How to Realize Uniform Three-Dimensional Ellipsoidal Electron Bunches (2004)

Uniform three-dimensional ellipsoidal distributions of charge are the ultimate goal in charged particle accelerator physics because of their linear internal force fields. Such bunches remain ellipsoidal with perfectly linear position-momentum phase space correlations in any linear transport system. We present a method, based on photoemission by radially shaped femtosecond laser pulses, to actually produce such bunches.
Industrial-strength data warehousing (1998)

article Free Access Share on Industrial-strength data warehousing Authors: Arun Sen Texas A&M Univ., College Station, Tex Texas A&M Univ., College Station, TexView Profile , Varghese S. Jacob Univ. of Texas, Dallas, Richardson Univ. of Texas, Dallas, RichardsonView Profile Authors Info & Claims Communications of the ACMVolume 41Issue 9Sept. 1998 pp 28–31https://doi.org/10.1145/285070.285076Published:01 September 1998Publication History 25citation1,317DownloadsMetricsTotal Citations25Total Downloads1,317Last 12 Months36Last 6 weeks19 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. (1995)

It appears that no organism is immune to the effects of nonsense codons on mRNA abundance. The study of how nonsense codons alter RNA metabolism is still at an early stage, and our current understanding derives more from incidental vignettes than from experimental undertakings that address molecular mechanisms. Challenges for the future include identifying the gene products and RNA sequences that function in nonsense mediated RNA loss, resolving the cause and consequences of there apparently being more than one cellular site and mechanism for nonsense-mediated RNA loss, and understanding how these sites and mechanisms are related to both constitutive and specialized pathways of pre-mRNA processing and mRNA decay.
Ultrasound Transient Shear Wave Elasticity Imaging for Tendon Tissue (2010)

Degeneration of tendon tissue is a common cause of tendon dysfunction with the symptoms of repeated episodes of pain and palpable increase of tendon thickness. Tendon mechanical properties are directly related to its physiological composition and the structural organization of the interior collagen fibers which could be altered by tendon degeneration due to overuse or injury. Thus, measuring mechanical properties of tendon tissue may represent a quantitative measurement of pain, reduced function, and tissue health. Ultrasound elasticity imaging has been developed in the last two decades and has proved to be a promising tool for tissue elasticity imaging. To date, however, well established protocols of tendinopathy elasticity imaging for diagnosing tendon degeneration in early stages or late stages do not exist. This thesis describes the re-creation of one dynamic ultrasound elasticity imaging method and the development of an ultrasound transient shear wave elasticity imaging platform for tendon and other musculoskeletal tissue imaging. An experimental mechanical stage with proper supporting systems and accurate translating stages was designed and made. A variety of high-quality tissue-mimicking phantoms were made to simulate homogeneous and heterogeneous soft tissues as well as tendon tissues. A series of data acquisition and data processing programs were developed to collect the displacement data from the phantom and calculate the shear modulus and Young’s modulus of the target. The imaging platform was found to be capable of conducting comparative measurements of the elastic parameters of the phantoms and quantitatively mapping elasticity onto ultrasound B-Mode images. This suggests the system has great potential for not only benefiting individuals with tendinopathy with an earlier detection, intervention and better rehabilitation, but also for providing a medical tool for quantification of musculoskeletal tissue dysfunction in other regions of the body such as the shoulder, elbow and knee.