gebhart/patrepeval huggingface dataset:
Interpenetrating Polymer Networks Based on SBR/PS. 2. Influence of Synthetic Detail and Morphology on Mechanical Behavior (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInterpenetrating Polymer Networks Based on SBR/PS. 2. Influence of Synthetic Detail and Morphology on Mechanical BehaviorA. A. Donatelli, L. H. Sperling, and D. A. ThomasCite this: Macromolecules 1976, 9, 4, 676–680Publication Date (Print):July 1, 1976Publication History Published online1 May 2002Published inissue 1 July 1976https://pubs.acs.org/doi/10.1021/ma60052a030https://doi.org/10.1021/ma60052a030research-articleACS PublicationsRequest reuse permissionsArticle Views283Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PDATS Lossless Address Trace Compression For Reducing File Size And Access Time (2005)

The tremendous storage space required for a useful data base of traces has driven a search for trace compaction techniques. In this paper we present an information-lossless trace compression scheme that can reduce both storage space and access time by an order of magnitude or more, compared to ASCII-format traces, without discarding either references or inter-reference timing from the original trace. This technique has been selected as the standard trace format for an extensive new trace data base that will be made accessible to the international research and teaching community.
ChemInform Abstract: EFFECT OF BUTYLLITHIUM ON 6H‐1,3,4‐THIADIAZINES (1982)

Abstract Unter anaeroben Bedingungen werden Aminothiadiazine wie z.B. (II) mit Butyl‐Li zu den Pyrazolen (IIIa) bis (IIIc) entschwefelt, wobei (IIIc) von geringen Mengen der Disulfide (IVc) begleitet werden.
Studies on derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. IV. Addition reactions of thioglycolic acid to 2-N-aralkylidene derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. (1981)

In the course of studies on compounds with expected antiinflammatory and immunosuppressive activity a series of new derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid have been synthesized. Several new and unexpected details of the chemical properties of these compounds were revealed. The chemical structure of the new compounds was confirmed by degradation and identification of the decomposition products and by spectral analysis.
Labor Induction With 25 μg Versus 50 μg Intravaginal Misoprostol (2002)

In Brief OBJECTIVE To systematically review published randomized controlled trials (RCTs) to compare the safety and efficacy of 25 μg versus 50 μg of intravaginal misoprostol for cervical ripening and labor induction. DATA SOURCES We supplemented a search of entries in electronic databases with references cited in original studies and review articles to identify RCTs of misoprostol for cervical ripening and labor induction, which compared repeated doses of 25 μg and 50 μg. STUDY SELECTION We evaluated, abstracted data, and assessed the quality of RCTs to compare the safety and efficacy of 25 μg versus 50 μg of intravaginal misoprostol for cervical ripening and labor induction. TABULATION, INTEGRATION, AND RESULTS Five RCTs met inclusion criteria for meta-analysis. Odds ratios (OR) with 95% confidence intervals (CI) were calculated for each outcome (random- and fixed-effects models). In addition, we aggregated the results of two separate studies, permitting an indirect comparison of the two doses being analyzed. In the meta-analysis, tachysystole and hyperstimulation syndrome appear to occur less frequently among women who received 25 μg of misoprostol than with 50 μg. However, neonatal outcomes appear to be comparable with the two doses. Regarding efficacy, use of the 50-μg dose was associated with a shorter interval to vaginal delivery, greater proportion of deliveries within 24 hours, and less frequent need for oxytocin augmentation. The indirect comparison of two studies yielded similar results. CONCLUSION Published data indicate that intravaginal misoprostol at doses of 50 μg for cervical ripening and labor induction is more efficacious but it is unclear whether it is as safe as the 25-μg dose. Cervical ripening and labor induction with 50 µg of intravaginal misoprostol is more effective but it is unclear whether it is as safe as the 25-µg dose.
Verifying cloud services (2013)

As cloud-based services gain popularity in both private and enterprise domains, cloud consumers are still lacking in tools to verify that these services work as expected. Such tools should consider properties such as functional correctness, service availability, reliability, performance and security guarantees. In this paper we survey existing work in these areas and identify gaps in existing cloud technology in terms of the verification tools provided to users. We also discuss challenges and new research directions that can help bridge these gaps.
Meningococcal Outer Membrane Protein NhhA Is Essential for Colonization and Disease by Preventing Phagocytosis and Complement Attack (2008)

Neisseria meningitidis is a leading cause of meningitis and septicemia worldwide, with a rapid onset of disease and a high morbidity and mortality. NhhA is a meningococcal outer membrane protein included in the family of trimeric autotransporter adhesins. The protein binds to the extracellular matrix proteins heparan sulfate and laminin and facilitates attachment to host epithelial cells. In this study, we show that NhhA is essential for bacterial colonization of the nasopharyngeal mucosa in a murine model of meningococcal disease. Successful colonization depends on bacterial attachment but also to the capacity to overcome innate host immune responses. We found that NhhA protected bacteria from phagocytosis, which is important for the mucosal survival of bacteria. In addition, NhhA mediated extensive serum resistance that increased bacterial survival in blood and promoted lethal sepsis. The presence of NhhA protected bacteria from complement-mediated killing by preventing the deposition of the membrane attack complex. Taken together, the results of this work reveal that NhhA inhibits phagocytosis and protects bacteria against complement-mediated killing, which enhances both nasal colonization and the development of sepsis in vivo.
Distributed power flow calculation for whole networks including transmission and distribution (2008)

Traditionally, transmission and distribution power flows are studied separately. But lots of large cities have their hybrid transmission and distribution networks. In order to achieve a global unified power flow solution, transmission and distribution networks are studied as a whole in this paper. Global power flow (GPF) equation is built as a mathematical model for the global power system. Based upon the master-slave-typed feature of the global power system, a master-slave-splitting (MSS) iterative method is developed for balancing the boundary mismatch between the transmission and distribution networks. In this method, the GPF problem of large scale is split into a transmission power flow and lots of distribution power flow sub-problems, which supports on-line geographically distributed computation. In order to fit the different features between transmission and distribution networks, each sub-problem can be solved with different algorithms. Several case studies are carried out, and accuracy, efficiency and reliability of the proposed method are verified.
An overview of wireless intrusion prevention systems (2010)

With the fast development of wireless network, the problems on wireless security have become more and more prominence. And technologies of firewall and intrusion detection cannot solve these problems satisfactorily. However, wireless intrusion prevention systems which can prevent attacks for WLAN excellently have become the research hotspot. In this paper, we firstly indicate the developing history of WIPS, and then summarize the related work on WIPS in academic and engineering application area respectively. Based on these work, we propose a common wireless intrusion prevention framework (CWIPF), and describe some key technologies used in this framework. Finally, we propose some research issues should be focused on in the future.
Research Spotlight: Magnetofection™ Platform: From Magnetic Nanoparticles to Novel Nucleic Acid Therapeutics (2011)

Nucleic acid delivery to cells to make them produce a desired protein or to shut down the expression of endogenous genes opens unique possibilities for research and therapy. During the last decade, to realize the potential of this approach, nanomagnetic methods for delivering and targeting nucleic acids have been developed, methods which are often referred to as Magnetofection. Our research group at the Institute of Experimental Oncology and Therapy Research, located at the University Hospital Klinikum rechts der Isar in the center of Munich, Germany, develops new magnetic nanomaterials and, their formulations with gene-delivery vectors and technologies to allow localized and efficient gene delivery in vitro and in vivo for a variety of research, diagnostic and therapeutic applications.
Endobacteria in some ectomycorrhiza of Scots pine (Pinus sylvestris) (2006)

The diversity of cultivable endobacteria associated with four different ectomycorrhizal morphotypes (Suillus flavidus, Suillus variegatus, Russula paludosa and Russula sp.) of Scots pine (Pinus sylvestris) was analysed by restriction fragment length polymorphism profiling of PCR-amplified rDNA intergenic spacer regions and by sequence analyses of 16S rRNA genes. Ectomycorrhizal root tip surface-sterilization methods were developed and assessed for their efficiencies. Bacterial communities from surface-sterilized ectomycorrhizal root tips were different from those of ectomycorrhizal root tips without surface-sterilization for all the morphotypes studied. Endobacteria belonging to the genera Pseudomonas, Burkholderia and Bacillus were isolated from more than one ectomycorrhizal morphotype, whereas species of Rahnella, Janthinobacterium and Rhodococcus were only isolated from the single morphotypes of S. variegatus, R. paludosa and Russula sp., respectively. Some of the isolated endobacteria utilized fungal sugars more readily than typical plant sugars in carbon utilization assays.
Increases in core body temperature precede hot flashes in a prostate cancer patient (2008)

This case study suggests that hot flashes in men may be preceded by increases in core body temperature. Identification of behavioral factors that raise core body temperature may lead to specific treatment strategies to reduce the frequency of hot flashes.
A constrained reconstruction technique of hyperelasticity parameters for breast cancer assessment (2010)

In breast elastography, breast tissue usually undergoes large compression resulting in significant geometric and structural changes. This implies that breast elastography is associated with tissue nonlinear behavior. In this study, an elastography technique is presented and an inverse problem formulation is proposed to reconstruct parameters characterizing tissue hyperelasticity. Such parameters can potentially be used for tumor classification. This technique can also have other important clinical applications such as measuring normal tissue hyperelastic parameters in vivo. Such parameters are essential in planning and conducting computer-aided interventional procedures. The proposed parameter reconstruction technique uses a constrained iterative inversion; it can be viewed as an inverse problem. To solve this problem, we used a nonlinear finite element model corresponding to its forward problem. In this research, we applied Veronda-Westmann, Yeoh and polynomial models to model tissue hyperelasticity. To validate the proposed technique, we conducted studies involving numerical and tissue-mimicking phantoms. The numerical phantom consisted of a hemisphere connected to a cylinder, while we constructed the tissue-mimicking phantom from polyvinyl alcohol with freeze-thaw cycles that exhibits nonlinear mechanical behavior. Both phantoms consisted of three types of soft tissues which mimic adipose, fibroglandular tissue and a tumor. The results of the simulations and experiments show feasibility of accurate reconstruction of tumor tissue hyperelastic parameters using the proposed method. In the numerical phantom, all hyperelastic parameters corresponding to the three models were reconstructed with less than 2% error. With the tissue-mimicking phantom, we were able to reconstruct the ratio of the hyperelastic parameters reasonably accurately. Compared to the uniaxial test results, the average error of the ratios of the parameters reconstructed for inclusion to the middle and external layers were 13% and 9.6%, respectively. Given that the parameter ratios of the abnormal tissues to the normal ones range from three times to more than ten times, this accuracy is sufficient for tumor classification.
Expression Profiling Identifies Altered Expression of Genes That Contribute to the Inhibition of Transforming Growth Factor-β Signaling in Ovarian Cancer (2006)

Ovarian cancer is resistant to the antiproliferative effects of transforming growth factor-beta (TGF-beta); however, the mechanism of this resistance remains unclear. We used oligonucleotide arrays to profile 37 undissected, 68 microdissected advanced-stage, and 14 microdissected early-stage papillary serous cancers to identify signaling pathways involved in ovarian cancer. A total of seven genes involved in TGF-beta signaling were identified that had altered expression >1.5-fold (P < 0.001) in the ovarian cancer specimens compared with normal ovarian surface epithelium. The expression of these genes was coordinately altered: genes that inhibit TGF-beta signaling (DACH1, BMP7, and EVI1) were up-regulated in advanced-stage ovarian cancers and, conversely, genes that enhance TGF-beta signaling (PCAF, TFE3, TGFBRII, and SMAD4) were down-regulated compared with the normal samples. The microarray data for DACH1 and EVI1 were validated using quantitative real-time PCR on 22 microdissected ovarian cancer specimens. The EVI1 gene locus was amplified in 43% of the tumors, and there was a significant correlation (P = 0.029) between gene copy number and EVI1 gene expression. No amplification at the DACH1 locus was found in any of the samples. DACH1 and EVI1 inhibited TGF-beta signaling in immortalized normal ovarian epithelial cells, and a dominant-negative DACH1, DACH1-Delta DS, partially restored signaling in an ovarian cancer cell line resistant to TGF-beta. These results suggest that altered expression of these genes is responsible for disrupted TGF-beta signaling in ovarian cancer and they may be useful as new and novel therapeutic targets for ovarian cancer.
Enkephalin‐degrading enzymes and angiotensin‐converting enzyme in human and rat meninges (1987)

The neutral endopeptidase NEP 24.11 (enkephalinase) has been visualized in human spinal cord by in vitro autoradiography using [3H]HACBO-Gly as a radiolabelled probe. The specific binding was present in the substantia gelatinosa and particularly dense in meninges surrounding the spinal cord. Enzymatic studies using [3H][D-Ala2, Leu]enkephalin as substrate confirmed the presence of NEP in dura and pia mater of human tissue. In addition, the human meninges were shown to contain high concentrations of angiotensin-converting enzyme (ACE) and aminopeptidases. The three enzymes have also been detected in rat tissues but their distribution pattern differs from that of human tissue. In dura mater, 45% of the [Leu]enkephalin hydrolysis was due to enkephalinase and 38% to bestatin-sensitive aminopeptidases. In contrast in pia mater aminopeptidases were more efficient in hydrolyzing enkephalin. The possible role of these enzymes in the meninges could be to maintain the homeostatic concentration of neuropeptides in the central nervous system.
Hardware-oriented direction-based fast fractional motion estimation algorithm in H.264/AVC (2008)

In this paper, a hardware-oriented fast fractional motion estimation (FME) algorithm for H.264/AVC is proposed. For both 1/2-pixel and 1/4-pixel FME, only 4 points are searched, and thus the required processing unit (PU) number is reduced from 9 to 4. Experiments show that the proposed algorithm can provide very similar image quality as full search, and the average PSRN drop is 0.17dB or bitrate increase is 4.08%. Compared with the full search FME hardware architecture [5], the proposed algorithm can effectively reduce about 32.3% hardware cost and thus is very suitable for low-cost and low-power applications.
FUNCTIONAL INTEGRITY OF T, B, AND NATURAL KILLER CELLS IN HOMOSEXUAL SUBJECTS WITH PRODROMATA AND IN PATIENTS WITH AIDS<sup>a</sup> (1984)

We have examined the numbers of the total T (T11+) cells, T-helper (T4+) cells, T-suppressor (T8+) cells, NK cells (Leu7+), and the functional integrity of T, B, and NK cells in healthy male heterosexuals and compared the data to those obtained from AIDS patients and male homosexuals at risk. The absolute number of total T (T11+) and T-helper (T4+) cell populations were significantly reduced among most of the asymptomatic homosexual males and even more decreased in the AIDS patients. By contrast, the absolute numbers of T-suppressor cells (T8) remained virtually unaltered in the three study populations. The absolute numbers of circulating natural killer cells were similar in the controls and the homosexual subjects, but significantly reduced in the AIDS patients. Proliferative responses to T-cell mitogen (PHA) and T-cell dependent B-cell mitogen (PWM) were severely impaired in prodromal subjects and more so in the AIDS group. Response to PWM was unrelated to the total number of T-suppressor cells, but was associated with a significant decrease in T-helper cell number. Furthermore, all AIDS patients exhibited a significantly depressed NK-cell activity that could not be normalized by addition of alpha IFN or IL-2 and in most cases correlated with the reduced absolute number of NK (Leu7+) cells as well as T-helper cells (T4) and T4/T8 ratios. Three distinctive subgroups with normal (N-NK), significantly heightened (H-NK), and markedly lowered (L-NK) NK activity could be readily identified among the homosexual male population at risk. The N-NK and L-NK groups displayed marginal to no response to in vitro treatment with alpha IFN and interleukin-2. The NK-cell activity, however, in the H-NK group was moderately to strongly inhibited by inclusion of the two immunomodifiers.
Technique for checking design rules for three-dimensional CAD data (2010)

A technique was developed for checking whether three-dimensional CAD shape satisfies design rules. Many design rules related to reliability and manufacturability should be considered in the design stage. Our technique automatically recognizes feature shapes such as a rib and boss from a CAD model shape, and it checks the shape and arrangement. The effectiveness of the technique was demonstrated in a test of the injection-molded part.
PP.19.20 (2015)

Objective: Dietary sugar and fat contribute to adiposity and are deleterious to cardiovascular heath. In addition, high dietary fructose in the absence of dietary fat induces leptin resistance and exacerbates subsequent HF-induced obesity. In addition, augmented leptin is associated with arterial stiffness. Thus, we hypothesized that a high-fat/high-fructose (HF/F) diet would have more severe consequences than a high-fat (HF) or chow diet on cardiovascular health. Design and method: Male Sprague Dawley rats were fed either with chow, HF (30%) or HF/F (30%/44%) diets for 12 weeks (N = 8-10/group) and adiposity, basilar artery reactivity, basilar artery wall thickness, heart weight, and biochemical parameters assessed. Basilar artery was cannulated in a pressurized system (90 cm H2O). Results: Vascular contractile responses to KCl (30-120 mM) were unchanged whereas both HF and HF/F diets decreased relaxation responses to papaverin (10-10-10-4 M, direct smooth muscle); acetylcholine (ACh) (10-10-10-4 M, endothelium dependent); and diethylamine (DEA)-NONO-ate (10-10-10-4 M, endothelium independent) relaxation compared to chow. The log EC50 values were -5.84, chow; -4.87, HF; -4.98, HF/F, p < .05 for papaverin; -6.48, chow; -5.65, HF; 5.79HF/F, p < 0.05 for Ach) and -5.94, chow; -4.45, HF; -4.49, HF/F, p < .05 for DEA. Artery wall thickness was increased only in HF group (27 ± 1.6 μm) compared with chow (22 ± 1.2, p < .05) and eNOS immunofluroescence was decreased by 50% in HF and HF/F diets (arbitrary units, p < .05). Adipose tissue weights (10.7 ± .5 HF; 12.7 ± .8 HF/F vs 7.8 ± .3 chow, p < .05) and total adiposity by TDNMR were elevated by the same degree in both HF and HF/F diets. Blood triglycerides (157 ± 32 mg/dl) and leptin (10.4 ± 1.8ng/ml) were greater with HF/F diet than with HF (65 ± 15; 6.6 ± .6) or chow diet (63 ± 14; 4.1 ± .3). Conclusions: In conclusion, both HF diets impaired basilar artery relaxation, and increased heart weight potentially due to decreased eNOS synthesis. Although, leptin and triglycerides were greater with HF/F diet only the HF increased wall thickness. These data suggest that the presence of high fructose in a HF diet does not exacerbate the detrimental consequences of a HF diet on cardiovascular health.
Targeting the translational machinery as a novel treatment strategy for hematologic malignancies (2010)

The dysregulation of protein synthesis evident in the transformed phenotype has opened up a burgeoning field of research in cancer biology. Translation initiation has recently been shown to be a common downstream target of signal transduction pathways deregulated in cancer and initiated by mutated/overexpressed oncogenes and tumor suppressors. The overexpression and/or activation of proteins involved in translation initiation such as eIF4E, mTOR, and eIF4G have been shown to induce a malignant phenotype. Therefore, understanding the mechanisms that control protein synthesis is emerging as an exciting new research area with significant potential for developing innovative therapies. This review highlights molecules that are activated or dysregulated in hematologic malignancies, and promotes the transformed phenotype through the deregulation of protein synthesis. Targeting these proteins with small molecule inhibitors may constitute a novel therapeutic approach in the treatment of cancer.