gebhart/patrepeval huggingface dataset:
Insulin Induction of SOCS-2 and SOCS-3 mRNA Expression in C2C12 Skeletal Muscle Cells Is Mediated by Stat5* (2001)

Previously, by a yeast 2-hybrid screen, we identified signal transducer and activator of transcription 5b (Stat5b) as a substrate of the insulin receptor (IR). We demonstrated that refeeding of fasted mice leads to rapid activation of Stat5 proteins in liver, skeletal muscle, and fat, suggesting that Stat5b is a physiological target of insulin. Here, we show that injection of glucose or insulin into fasted mice leads to robust activation of both Stat5a and Stat5b in skeletal muscle. In C2C12 myotubes, we find that insulin stimulates tyrosine phosphorylation of Stat5a and Stat5b by 3-5-fold. This degree of Stat5 activation in vitro is significantly lower than what we observe in vivo and inversely correlates with IRS-1/2 levels. We can recapitulate robust insulin activation of Stat5 in C2C12 cells by stable overexpression of the human IR (hIR). To identify insulin-activated genes that are Stat5 targets, we also overexpressed an IR mutant (LA-hIR) that signals normally for mitogen-activated protein kinase- and phosphatidylinositol 3-kinase-dependent pathways but is deficient in Stat5 signaling in response to insulin. We demonstrate that insulin induces the expression of SOCS-2 mRNA in the wild type hIR but not in the LA-hIR-overexpressing cells. The induction of SOCS-3 by insulin is reduced but not lost in the LA-hIR cells. Therefore, our results suggest that insulin induction of SOCS-2, and in part SOCS-3 mRNA expression, is mediated by Stat5 and can be independent of mitogen-activated protein kinase and phosphatidylinositol 3-kinase-signaling pathways.
Integrated Control and Scheduling (1999)

The report gives a state-of-the-art survey of the field of integrated control and scheduling. Subtopics discussed are implementation and scheduling of periodic control loops, scheduling under overload, control and scheduling co-design, dynamic task adaptation, feedback scheduling, and scheduling of imprecise calculations. The report also presents the background, motivation, and research topics in the ARTES project Integrated Control and Scheduling.
Computer discrimination between benign and malignant urothelial cells. (1975)

Computer discrimination between benign and malignant cells by means of the TICAS routines and subroutines has been accomplished with a small error of classification, not greater than ten percent. One feature of major diagnostic significance, namely, nuclear texture was singled out for discussion. This study augurs well for the future of computerized cytology of the urinary tract.
Risk Indicators for Reported Over-Exertion Back Injuries among Female Nursing Personnel (2000)

We conducted a case-referent study to identify and quantify work-related and non-work-related risk indicators for reported over-exertion back injuries among nursing personnel. The source population was all nursing personnel employed in the Stockholm County hospitals during a 32-month period. The 240 cases and 614 referents completed questionnaires about occupation, type of clinic, working hours, shift work, patient transfers, perceived exertion, back pain, prior back injury, job strain, body mass index (BMI), smoking, immigrant status, physical training, and self-rated fitness. The highest relative risks (RR) were observed for work-related factors: working at an orthopedic clinic (RR = 5.2; 95% CI = 2.7-10.2), > or =1 patient transfer/shift (RR = 2.7; 95% CI = 1.6-4.5), and working full-time (RR = 2.4; 95% CI = 1.6-3.6). Training in the use of transfer devices, and regular use of transfer devices, reduced the relative risk from patient transfer. Among the non-work-related factors, only body mass index > or =25 kg/m2 and immigrant status was associated with a slight increase in relative risk.
Phylogenetic Relationships of <i>Xylella fastidiosa</i> Strains Isolated from Landscape Ornamentals in Southern California (2007)

ABSTRACT Xylella fastidiosa is an insect-borne, xylem-limited pathogenic bacterium that has been associated with a rise in incidence of diseased landscape ornamentals in southern California. The objective of this study was to genetically characterize strains isolated from ornamental hosts to understand their distribution and identity. Strains of X. fastidiosa isolated from ornamentals were characterized using a multiprimer polymerase chain reaction (PCR) system, random amplified polymorphic DNA (RAPD)-PCR, and sequence analysis of the 16S-23S rDNA intergenic spacer region (ISR). Based on RAPD-PCR and 16S-23S rDNA ISR, strains isolated from daylily, jacaranda, and magnolia clustered with members of X. fastidiosa subsp. sandyi and caused oleander leaf scorch but not Pierce's disease symptoms in glasshouse assays on oleander and grape, respectively. This demonstrated both that our groupings based on genetic characterization were valid and that strains of X. fastidiosa subsp. sandyi are present in hosts other than oleander. Strains isolated from Spanish broom, cherry, and one strain isolated from western redbud clustered with X. fastidiosa subsp. fastidiosa members. Strains isolated from purple-leafed plum, olive, peach, plum, sweetgum, maidenhair tree, crape myrtle, and another western redbud strain clustered with members of X. fastidiosa subsp. multiplex. All strains isolated from mulberry and one from heavenly bamboo formed a separate cluster that has not yet been defined as a subspecies.
Enabling Seamless Coverage and Mobility Support for 60 GHz Networks Using Pose Information (2017)

60 GHz millimeter-wave networking has emerged as the next frontier technology to provide multi-Gbps wireless connectivity. Recently proposed mmWave network standards, like 802.11ad, have spawned a new wave of applications such as wireless virtual reality and uncompressed miracast. However, due to ultra-high carrier frequency, the 60 GHz radios are extremely vulnerable to propagation loss and obstacle blockage. To combat the intrinsic signal attenuation, the use of highly directional phased-array antennas, with limited Field-of-view (FoV), makes the mmWave links extremely sensitive to user mobility and orientation change. Hence, achieving stable 60 GHz connectivity, even at room-level, becomes a nontrivial task. My research has been focusing on a series of techniques to address these challenges. These techniques leverage extraneous sensing information to facilitate the mmWave protocols, so as to provide room-scale coverage at multi-Gbps bit-rate. In this talk, I will first outline the impact of limited FoV of the 60 GHz radio under mobility, and then present a robust 60 GHz network architecture, in which multiple cooperating APs can complement others' blind spots and together form seamless coverage. I will then describe two design components: pose-assisted link predictor and pose-assisted spatial sharing. They leverage the pose information from mobile devices, and improve the 60 GHz network robustness under mobility through intelligent AP switching and beam selection. Finally, to account for the impact of reflections from close-by objects, I will introduce an environment sensing method, which fuses the pose information with the link quality measurement, to computationally discriminate the refection paths and model their impacts separately.
Evaluation of bioluminescent imaging for noninvasive monitoring of colorectal cancer progression in the liver and its response to immunogene therapy (2009)

We show that BLI is a rapid, convenient and safe technique for the individual monitorization of tumor progression in the liver. Evaluation of experimental treatments with complex mechanisms of action such as immunotherapy is possible using this technology.
Metal complexes with tetrapyrrole ligands. 46. Europium(III) bis(octaethylporphyrinate), a lanthanoid porphyrin sandwich with porphyrin rings in different oxidation states, and dieuropium(III) tris(octaethylporphyrinate) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal complexes with tetrapyrrole ligands. 46. Europium(III) bis(octaethylporphyrinate), a lanthanoid porphyrin sandwich with porphyrin rings in different oxidation states, and dieuropium(III) tris(octaethylporphyrinate)Johann W. Buchler, Andre De Cian, Jean Fischer, Martina Kihn-Botulinski, and Raymond WeissCite this: Inorg. Chem. 1988, 27, 2, 339–345Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ic00275a022https://doi.org/10.1021/ic00275a022research-articleACS PublicationsRequest reuse permissionsArticle Views463Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Percutaneous Transjugular Portosystemic Shunt (1991)

--Initial results suggest that transjugular intrahepatic portosystemic shunt is a safe and effective method of portal decompression for the treatment of variceal hemorrhage.
Uptake of the cation hexakis(2-methoxyisobutylisonitrile)-technetium-99m by human carcinoma cell lines in vitro. (1990)

Uptake of the cationic compound hexakis(2-methoxyisobutylisonitrile)-technetium-99m ([99mTc]MIBI) was examined in nine human tumor cell lines. The concentration of [99mTc]MIBI after a 1-h incubation with the compound varies from 5 to 28% of the activity in the external medium. In contrast, normal V79 cells (Chinese hamster lung fibroblasts) and human peripheral blood mononuclear cells exhibit a minimal uptake of less than 2% of the activity in the medium. Kinetic experiments with SW-13 cells indicate a rapid uptake over time (t1/2 of 10 min) until a steady state is approached whose concentration appears directly correlated with the extracellular concentration of [99mTc]MIBI with no evidence of saturation over the range tested (10(-12)-10(-9) M). [99mTc]MIBI is taken up by a temperature dependent process that is restricted to living cells. Microautoradiography demonstrates that [99mTc]MIBI is clustered in the cytoplasm around the nucleus. Given that depolarizing the plasma membrane potential in high K+ buffer results in lowering the uptake of [99mTc]-MIBI and that alteration of the mitochondrial membrane potential with valinomycin or nigericin induces, respectively, a significant decrease or increase of [99mTc]MIBI uptake, we propose that the plasma and mitochondrial membrane potentials play a major role in the uptake. These data suggest that the gamma emitter [99mTc]MIBI exhibits interesting tumor cell interaction characteristics with promise for in vivo tumor imaging.
CURRENT CONCEPTS OF ACTIVE DEFENSE IN PLANTS (1998)

A growing body of evidence indicates that elicitation of primary active defense responses results from a recognition event frequently involving protein-protein interactions. Most pathogen avirulence determinants eliciting resistance gene-dependent responses have been shown to be proteins with no apparent enzymic activity. Disruption of the tertiary and quaternary structure of these proteins abolishes their elicitor activity. Critical to their elicitor activity is their display by the pathogen. Resistance genes are proposed to function as receptors for the eliciting proteins. The most consistent feature of resistance gene products is the presence of potential protein binding domains in the form of leucine-rich repeat regions, and there is direct evidence for the physical interaction of elicitor proteins and receptor proteins in several cases. Thus in many but not all cases the primary recognition event eliciting an active defense response during incompatible interactions appears to be a protein-protein interaction occurring between a specific pathogen protein and a strategically placed receptor protein in the host cell. The interaction of elicitor protein with the receptor protein activates a signal transduction pathway leading to programmed cell death and an oxidative burst.
Data handling displays (2009)

Imagine a world in which people can use their hand-held mobile devices to project and transfer content. Everyone can join the collaboration by simply bringing their mobile devices close to each other. People can grab data from each others' devices with simple hand gestures. Now imagine a large display created by tiling multiple displays where multiple users can interact with a large dynamically changing data set in a collocated, collaborative setting and the displays will take care of the data transfer and handling functions in a way that is transparent to the users. In this paper we present a novel data-handling display which works as not only a display device but also as an interaction and data transfer module. We propose simple gesture based solutions to transfer information between these data-handling modules. We achieve high scalability by presenting a fully distributed architecture in which each device is responsible for its own data and also communicates and collaborates with other devices. We also show the usefulness of our work in visualizing large datasets and at the same time allowing multiple users to interact with the data.
Synthesis and Human Telomerase Inhibition of a Series of Regioisomeric Disubstituted Amidoanthraquinones (2007)

Telomerase is the enzymatic activity that maintains the ends of eukaryotic chromosomes. Telomerase activity is detected in most tumor cells whereas it is low or undetectable in most normal somatic cells. Expression of the telomerase catalytic component, the human telomerase reverse transcriptase (hTERT), is believed to be controlled primarily at the level of transcription. Because of this selective expression property of telomerase, it has been touted as a specific target for antitumor chemotherapeutics. However, a concern for the applicability of telomerase inhibitors is that they require a long lag time for telomeres to be shortened to critical length before cancer cells stop proliferating. Here we investigate telomerase inhibitory, cytotoxicity and the hTERT repressing effects on a number of synthesized 2,6-diamidoanthraquinones and 1,5-diamidoanthraquinones as compared to their disubstituted homologues. We found that several of the 1,5-diamidoanthraquinones and 2,6-diamidoanthraquinones inhibited telomerase activity effectively with IC50 at the sub-micro to micro molar range and caused acute cytotoxicity to cancer cells with EC50 similar or better than that of mitoxantrone. Particularly, 2,6-diamidoanthraquinone with 2-ethylaminoacetamido side chains 33, even though not affecting cell proliferation, showed to be endowed with a strong telomerase effect, probably related to a marked stabilization of the G-quadruplex-binding structure. The results suggested that these compounds caused multiple effects to cancer cells. More significantly, they overcome the long lag period problem of classical telomerase inhibitors that they are also potent cytotoxic agents. These results greatly expand the potential of tricyclic anthraquinone pharmacophore in preventive and/or curative therapy.
Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy (2012)

The hemolysis of red blood cells and muscle damage results in the release of the heme proteins myoglobin, hemoglobin, and free heme into the vasculature. The mechanisms of heme toxicity are not clear but may involve lipid peroxidation, which we hypothesized would result in mitochondrial damage in endothelial cells. To test this, we used bovine aortic endothelial cells (BAEC) in culture and exposed them to hemin. Hemin led to mitochondrial dysfunction, activation of autophagy, mitophagy, and, at high concentrations, apoptosis. To detect whether hemin induced lipid peroxidation and damaged proteins, we used derivatives of arachidonic acid tagged with biotin or Bodipy (Bt-AA, BD-AA). We found that in cells treated with hemin, Bt-AA was oxidized and formed adducts with proteins, which were inhibited by α-tocopherol. Hemin-dependent mitochondrial dysfunction was also attenuated by α-tocopherol. Protein thiol modification and carbonyl formation occurred on exposure and was not inhibited by α-tocopherol. Supporting a protective role of autophagy, the inhibitor 3-methyladenine potentiated cell death. These data demonstrate that hemin mediates cytotoxicity through a mechanism which involves protein modification by oxidized lipids and other oxidants, decreased respiratory capacity, and a protective role for the autophagic process. Attenuation of lipid peroxidation may be able to preserve mitochondrial function in the endothelium and protect cells from heme-dependent toxicity.
The Design and Implementation of the NetBSD rc.d System (2001)

In this paper I cover the design and implementation of the rc.d system start-up mechanism in NetBSD 1.5, which replaced the monolithic /etc/rc start-up file inherited from 4.4BSD. Topics covered include a history of various UNIX start-up mechanisms (including NetBSD prior to 1.5), design considerations that evolved over six years of discussions, implementation details, an examination of the human issues that occurred during the design and implementation, as well as future directions for the system.
60GHz power amplifier with distributed active transformer and local feedback (2010)

A 52-61 GHz power amplifier (PA) is implemented in 65nm CMOS bulk technology. The distributed active transformer (DAT) combines the output power from two unit PAs and achieves a peak output power of 14.8 dBm. Each unit PA uses two-stage differential cascode topology. This PA achieves a peak power gain of 10.2 dB with 10.8 dBm 1-dB compression output power (OP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1dB</sub> ) and a peak power-added efficiency (PAE) of 7.2%. The transformer based passives enable a compact active area of 0.3mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . This PA consumes a quiescent current of 143mA from a 1.6V supply voltage. Thanks to the linearization of last stage, the OP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1dB</sub> can be further improved to 11.8 dBm when the driver's supply voltage increases to 2.2V.
THE PREPARATION OF CHLOROVANILLIN AND SOME OF ITS DERIVATIVES<sup>1</sup> (1927)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE PREPARATION OF CHLOROVANILLIN AND SOME OF ITS DERIVATIVES1Raymond M. Hann and G. C. SpencerCite this: J. Am. Chem. Soc. 1927, 49, 2, 535–537Publication Date (Print):February 1, 1927Publication History Published online1 May 2002Published inissue 1 February 1927https://pubs.acs.org/doi/10.1021/ja01401a033https://doi.org/10.1021/ja01401a033research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chiral 2,2‘-Bipyridines, 1,10-Phenanthrolines, and 2,2‘:6‘,2‘ ‘-Terpyridines:  Syntheses and Applications in Asymmetric Homogeneous Catalysis (2002)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChiral 2,2'-Bipyridines, 1,10-Phenanthrolines, and 2,2':6',2' '-Terpyridines: Syntheses and Applications in Asymmetric Homogeneous CatalysisGiorgio Chelucci and Randolph P. ThummelView Author Information Dipartimento di Chimica, Università di Sassari, Via Vienna 2, 07100 Sassari, Italy, and Department of Chemistry, University of Houston, Houston, Texas 77204-5003 Cite this: Chem. Rev. 2002, 102, 9, 3129–3170Publication Date (Web):August 24, 2002Publication History Received22 October 2001Published online24 August 2002Published inissue 1 September 2002https://pubs.acs.org/doi/10.1021/cr0101914https://doi.org/10.1021/cr0101914research-articleACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views6732Altmetric-Citations475LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Hydrocarbons,Ketones,Ligands,Reaction products,Stereoselectivity Get e-Alerts