gebhart/patrepeval huggingface dataset:
AtNAC2, a transcription factor downstream of ethylene and auxin signaling pathways, is involved in salt stress response and lateral root development (2005)

An NAC-type transcription factor gene AtNAC2 was identified from Arabidopsis thaliana when expression patterns of the genes from a microarray analysis were examined. The AtNAC2 expression was induced by salt stress and this induction was reduced in magnitude in the transgenic Arabidopsis plants overexpressing tobacco ethylene receptor gene NTHK1. AtNAC2 is localized in the nucleus and has transcriptional activation activity. It can form a homodimer in yeast. AtNAC2 was highly expressed in roots and flowers, but less expressed in other organs examined. In addition to the salt induction, the AtNAC2 can also be induced by abscisic acid (ABA), ACC and NAA. The salt induction was enhanced in the ethylene overproducer mutant eto1-1, but suppressed in the ethylene-insensitive mutants etr1-1 and ein2-1, and in the auxin-insensitive mutant tir1-1when compared with that in wild-type plants. However, the salt induction of AtNAC2 was not significantly affected in the ABA-insensitive mutants abi2-1, abi3-1 and abi4-1. These results indicate that the salt response of AtNAC2 requires ethylene signaling and auxin signaling pathways but does not require ABI2, ABI3 and ABI4, intermediates of the ABA signaling pathway. Overexpression of AtNAC2 in transgenic Arabidopsis plants resulted in promotion of lateral root development. AtNAC2 also promoted or inhibited downstream gene expressions. These results indicate that AtNAC2 may be a transcription factor incorporating the environmental and endogenous stimuli into the process of plant lateral root development.
MMSE/PIC multiuser detection for DS/CDMA systems with inter- and intra-cell interference (1999)

This paper analyzes combinations of the linear minimum mean square error (MMSE) detector and a nonlinear parallel interference canceller (PIC) for multiuser code-division multiple-access (CDMA) detection. Both the case where all users' codes are known at the receiver and the case where only some codes are known are considered. An upper bound and an approximate formula for the error probability are derived and verified through simulation. It is shown that the combined MMSE/PIC detector can have a considerable performance gain over the MMSE. It is also shown that while the MMSE detector is sensitive to large code cross-correlation values, the combined MMSE/PIC detector is robust to code cross correlations. Finally, use of the MMSE/PIC detector for cellular systems with both inter- and intra-cell interference is considered.
Intrinsic optical fiber temperature sensor based on the differential absorption technique (1990)

A microprocessor-based instrument for temperature measurement has been developed based upon the intrinsic temperature sensitive absorption properties of a neodymium doped optical fiber. The accuracy and repeatability of temperature measurement are investigated with respect to the stability of environmentally sensitive system components. In the light of these investigations a prototype instrument employing novel compensation techniques has been developed. Accuracy and repeatability have been determined to be better than ±1 °C over a 20–200 °C temperature measurement range with the potential of increased range and accuracy for temperatures down to −100 °C.
Exploring VM Introspection (2015)

While there are a variety of existing virtual machine introspection (VMI) techniques, their latency, overhead, complexity and consistency trade-offs are not clear. In this work, we address this gap by first organizing the various existing VMI techniques into a taxonomy based upon their operational principles, so that they can be put into context. Next we perform a thorough exploration of their trade-offs both qualitatively and quantitatively. We present a comprehensive set of observations and best practices for efficient, accurate and consistent VMI operation based on our experiences with these techniques. Our results show the stunning range of variations in performance, complexity and overhead with different VMI techniques.We further present a deep dive on VMI consistency aspects to understand the sources of inconsistency in observed VM state and show that, contrary to common expectation, pause-and-introspect based VMI techniques achieve very little to improve consistency despite their substantial performance impact.
Anorganic bovine bone (<scp>ABB</scp>) vs. autologous bone (<scp>AB</scp>) plus <scp>ABB</scp> in maxillary sinus grafting. A prospective non‐randomized clinical and histomorphometrical trial (2014)

The usage of ABB plus AB to a 1/1 ratio leads to an amount of newly formed bone comparable with the solitary use of ABB after grafting of the maxillary sinus. Considering that ABB is a non-resorbable bone substitute, it can be hypothesized that this leads to stable bone over time and long-term implant success. Importantly, in the sole use of ABB, bone grafting and therefore donor site morbidities can be avoided.
Simulating the DASH architecture in HASE (2002)

HASE (Hierarchical computer Architecture design and Simulation Environment) allows for the rapid development and exploration of computer architectures at multiple levels of abstraction, encompassing both hardware and software. The user interacts with HASE via an X-Windows/Motif graphical interface, and one of the main forms of output is an animation of the design window. The DASH architecture was designed to prove the feasibility of building a scaleable high-performance machine with multiple coherent caches and a single address space. The HASE simulation therefore concentrates on implementing the cache coherency protocols, and the animator has been used to check that the simulation conforms to the architecture. Future work will involve performance checks of the simulator, and thence possible architectural enhancements.
The Role of Leptin-Melanocortin System and Human Weight Regulation: Lessons from Experiments of Nature (2009)

Despite exciting discoveries of single gene mutations resulting in human obesity, most cases of obesity are likely the result of subtle interactions of several related genetic variants with environmental factors which favour the net deposition of calories as fat, culminating in the obese phenotype. The mechanisms of action of these genes in the development of obesity are now being examined, with the aim of eventually discovering a therapeutic intervention for obesity.
The Immunoglobulin (IgG) Antibody Response to OspA and OspB Correlates with Severe and Prolonged Lyme Arthritis and the IgG Response to P35 Correlates with Mild and Brief Arthritis (1999)

In an effort to implicate immune responses to specific Borrelia burgdorferi proteins that may have a role in chronic Lyme arthritis, we studied the natural history of the antibody response to B. burgdorferi in serial serum samples from 25 patients monitored throughout the course of Lyme disease. In these patients, the immunoglobulin G (IgM) and IgG antibody responses to 10 recombinant B. burgdorferi proteins, determined during early infection, early arthritis, and maximal arthritis, were correlated with the severity and duration of maximal arthritis. The earliest responses were usually to outer surface protein C (OspC), P35, P37, and P41; reactivity with OspE, OspF, P39, and P93 often developed weeks later; and months to years later, 64% of patients had responses to OspA and OspB. During early infection and early arthritis, the levels of IgG antibody to P35 correlated inversely with the subsequent severity or duration of maximal arthritis. In contrast, during periods of maximal arthritis, the levels of IgG antibody to OspA and OspB, especially to a C-terminal epitope of OspA, correlated directly with the severity and duration of arthritis. Thus, the higher the IgG antibody response to P35 earlier in the infection, the milder and briefer the subsequent arthritis, whereas during maximal arthritis, the higher the IgG response to OspA and OspB, the more severe and prolonged the arthritis.
Approximating loops in a shortest homology basis from point data (2010)

Inference of topological and geometric attributes of a hidden manifold from its point data is a fundamental problem arising in many scientific studies and engineering applications. In this paper we present an algorithm to compute a set of loops from a point data that presumably sample a smooth manifold M ⊂ Rd. These loops approximate a shortest basis of the one dimensional homology group H1(M) over coefficients in finite field Z2. Previous results addressed the issue of computing the rank of the homology groups from point data, but there is no result on approximating the shortest basis of a manifold from its point sample. In arriving our result, we also present a polynomial time algorithm for computing a shortest basis of H1 (Κ) for any finite simplicial complex Κ whose edges have non-negative weights.
A Neuromorphic Architecture for Object Recognition and Motion Anticipation Using Burst-STDP (2012)

In this work we investigate the possibilities offered by a minimal framework of artificial spiking neurons to be deployed in silico. Here we introduce a hierarchical network architecture of spiking neurons which learns to recognize moving objects in a visual environment and determine the correct motor output for each object. These tasks are learned through both supervised and unsupervised spike timing dependent plasticity (STDP). STDP is responsible for the strengthening (or weakening) of synapses in relation to pre- and post-synaptic spike times and has been described as a Hebbian paradigm taking place both in vitro and in vivo. We utilize a variation of STDP learning, called burst-STDP, which is based on the notion that, since spikes are expensive in terms of energy consumption, then strong bursting activity carries more information than single (sparse) spikes. Furthermore, this learning algorithm takes advantage of homeostatic renormalization, which has been hypothesized to promote memory consolidation during NREM sleep. Using this learning rule, we design a spiking neural network architecture capable of object recognition, motion detection, attention towards important objects, and motor control outputs. We demonstrate the abilities of our design in a simple environment with distractor objects, multiple objects moving concurrently, and in the presence of noise. Most importantly, we show how this neural network is capable of performing these tasks using a simple leaky-integrate-and-fire (LIF) neuron model with binary synapses, making it fully compatible with state-of-the-art digital neuromorphic hardware designs. As such, the building blocks and learning rules presented in this paper appear promising for scalable fully neuromorphic systems to be implemented in hardware chips.
Combined source-channel transform for image transmission over wireless channel (2011)

The proposed communication system is based on a combined source-channel transform. Given particular scenarios of still image transmission over a wireless LOS channel, the proposed system demonstrates superior performance compared to a JPEG2000 + WirelessMAN OFDM system in restored image quality parameters over a wide range of wireless channel parameters. The proposed system provides progressive lossless image transmission under influence of moderate fading without any kind of channel coding. The proposed system employs a fast analysis/synthesis algorithm, which does not use any multiplications, and it uses three times less real additions than the one of JPEG2000 + WirelessMAN OFDM.
Systematic and optimal design of CMOS two-stage opamps with hybrid cascode compensation (2006)

This paper presents a systematic and optimal design of hybrid cascode compensation method which is used in fully differential two-stage CMOS operational transconductance amplifiers (OTAs). The closed loop analysis results are given to obtain a design procedure. A simple design procedure for the minimum settling time of the hybrid cascode compensation technique for a two-stage class A/AB amplifier is proposed. Optimal design issues of power dissipation are considered to achieve the lowest power consumption for the required settling time. Finally, a design example is presented to show both the usefulness of the hybrid cascode compensation and the proposed design procedure. The proposed design technique can help circuit designers as well as it can be used in computer aided circuit design tools
Blinded Prospective Evaluation of Computer-Based Mechanistic Schizophrenia Disease Model for Predicting Drug Response (2012)

The tremendous advances in understanding the neurobiological circuits involved in schizophrenia have not translated into more effective treatments. An alternative strategy is to use a recently published 'Quantitative Systems Pharmacology' computer-based mechanistic disease model of cortical/subcortical and striatal circuits based upon preclinical physiology, human pathology and pharmacology. The physiology of 27 relevant dopamine, serotonin, acetylcholine, norepinephrine, gamma-aminobutyric acid (GABA) and glutamate-mediated targets is calibrated using retrospective clinical data on 24 different antipsychotics. The model was challenged to predict quantitatively the clinical outcome in a blinded fashion of two experimental antipsychotic drugs; JNJ37822681, a highly selective low-affinity dopamine D(2) antagonist and ocaperidone, a very high affinity dopamine D(2) antagonist, using only pharmacology and human positron emission tomography (PET) imaging data. The model correctly predicted the lower performance of JNJ37822681 on the positive and negative syndrome scale (PANSS) total score and the higher extra-pyramidal symptom (EPS) liability compared to olanzapine and the relative performance of ocaperidone against olanzapine, but did not predict the absolute PANSS total score outcome and EPS liability for ocaperidone, possibly due to placebo responses and EPS assessment methods. Because of its virtual nature, this modeling approach can support central nervous system research and development by accounting for unique human drug properties, such as human metabolites, exposure, genotypes and off-target effects and can be a helpful tool for drug discovery and development.
The epidemiology of necrotizing enterocolitis infant mortality in the United States. (1997)

As mortality among low-birth weight infants continues to decline and smaller newborns survive early causes of death, necrotizing enterocolitis-associated infant mortality may increase.
Low-temperature transport properties of<i>p</i>-type<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">CoSb</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (1995)

Single crystals of the skutterudite ${\mathrm{CoSb}}_{3}$ exhibit large hole mobilities (up to 3000 ${\mathrm{cm}}^{2}$ ${\mathrm{V}}^{\mathrm{\ensuremath{-}}1}$ ${\mathrm{s}}^{\mathrm{\ensuremath{-}}1}$ at room temperature), intrinsic lattice thermal conductivity down to 10 K, and pronounced phonon drag effects in the thermoelectric power. The dependence of the mobility and diffusion thermopower on hole density is consistent with recent band-structure calculations, which indicate that ${\mathrm{CoSb}}_{3}$ possesses a highly nonparabolic valence-band structure.
Experimental study of injectable bone for regeneration using mesenchymal stem cells, fibrin glue, and a biodegradable scaffold (2003)

The purpose of this study was to investigate whether a combination of fibrin glue, biodegradable scaffold (β-tricalcium phosphate;β-TCP), and mesenchymal stem cells (MSCs) would promote new bone formation and provide three-dimensional templates for bone growth at heterotopic sites in rats with plasticity. Growing MSCs and developing matrices, explanted from the rat femur, were minced and mixed with fibrin glue in a syringe. The MSCs/fibrin glue-β-TCP complex was injected into the subcutaneous space of the back of the rat. Eight weeks after implantation, macroscopic examination revealed a pearly opalescence that was firm on palpation. Histologic investigations showed newly formed bone structures in all rats treated with the MSCs/fibrin glue-β-TCP complex. No bone structures were found in the fibrin glue or β-TCP control groups. Our results demonstrate that injectable MSCs/fibrin glue-β-TCP complex can provide a three-dimensional scaffold for the successful transplantation and engraftment of osteoblasts. This technique holds promise of becoming a minimally invasive means of delivering autogenous bone to correct or repair bone defects such as those associated with osteoprotic fractures, paradontosis, and tumor resection.
Granulocyte colony‐stimulating factor and differentiation‐induction in myeloid leukemic cells (1987)

The granulocyte colony-stimulating factor (G-CSF) belongs to a family of hemopoietic growth factors regulating the production of granulocytes and macrophages. Murine G-CSF stimulates the proliferation and differentiation of precursors of neutrophilic granulocytes and is also able to stimulate the functional activities of mature neutrophils. Among the hemopoietic growth factors, G-CSF has an outstanding capacity to induce terminal differentiation and suppression of self-renewal in myeloid leukemic cells. Murine and human G-CSF's show complete biological cross-reactivity across species and bind equally well to G-CSF receptors of either species. Specific receptors for G-CSF exist on all normal neutrophilic cells and have not been lost in the generation of primary human myeloid leukemias. This data indicates that G-CSF may be a useful reagent in the treatment of myeloid leukemia, in hemopoietic regeneration and in increasing resistance against infections.
Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar. (2000)

Sugars have signaling roles in a wide variety of developmental processes in plants. To elucidate the regulatory components that constitute the glucose signaling network governing plant growth and development, we have isolated and characterized two Arabidopsis glucose insensitive mutants, gin5 and gin6, based on a glucose-induced developmental arrest during early seedling morphogenesis. The T-DNA-tagged gin6 mutant abrogates the glucose-induced expression of a putative transcription factor, ABI4, previously shown to be involved in seed-specific abscisic acid (ABA) responses. Thus, ABI4 might be a regulator involved in both glucose- and seed-specific ABA signaling. The characterization of the gin5 mutant, on the other hand, reveals that glucose-specific accumulation of ABA is essential for hexokinase-mediated glucose responses. Consistent with this result, we show that three ABA-deficient mutants (aba1-1, aba2-1, and aba3-2) are also glucose insensitive. Exogenous ABA can restore normal glucose responses in gin5 and aba mutants but not in gin6 plants. Surprisingly, only abi4 and abi5-1 but not other ABA-insensitive signaling mutants (abi1-1, abi2-1, and abi3-1) exhibit glucose insensitivity, indicating the involvement of a distinct ABA signaling pathway in glucose responses. These results provide the first direct evidence to support a novel and central role of ABA in plant glucose responses mediated through glucose regulation of both ABA levels by GIN5 and ABA signaling by GIN6/ABI4.
A photoaffinity label for the D-1 dopamine receptor, (RS)-7-[125I]iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine, selectively identifies the ligand binding subunits of the receptor (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA photoaffinity label for the D-1 dopamine receptor, (RS)-7-[125I]iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine, selectively identifies the ligand binding subunits of the receptorNandkishore Baindur, John L. Neumeyer, Hyman B. Niznik, Natalie H. Bzowej, Kieth R. Jarvie, Phillip Seeman, Russell K. Garlick, and Joseph J. Miller Jr.Cite this: J. Med. Chem. 1988, 31, 11, 2069–2071Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/jm00119a003https://doi.org/10.1021/jm00119a003research-articleACS PublicationsRequest reuse permissionsArticle Views159Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ILUM: A Multi-Elimination ILU Preconditioner for General Sparse Matrices (1996)

Standard preconditioning techniques based on incomplete LU (ILU) factorizations offer a limited degree of parallelism, in general. A few of the alternatives advocated so far consist of either using some form of polynomial preconditioning or applying the usual ILU factorization to a matrix obtained from a multicolor ordering. In this paper we present an incomplete factorization technique based on independent set orderings and multicoloring. We note that in order to improve robustness, it is necessary to allow the preconditioner to have an arbitrarily high accuracy, as is done with ILUs based on threshold techniques. The ILUM factorization described in this paper is in this category. It can be viewed as a multifrontal version of a Gaussian elimination procedure with threshold dropping which has a high degree of potential parallelism. The, emphasis is on methods that deal specifically with general unstructured sparse matrices such as those arising from finite element methods on unstructured meshes.