gebhart/patrepeval huggingface dataset:
Abstract 4555: Protein and glycan biomarkers of malignant potential in pancreatic cyst fluid (2012)

Abstract The early detection of a portion of pancreatic cancer precursors_cystic neoplasms of the pancreas_is possible through high-resolution abdominal imaging, providing an opportunity to successfully treat these lesions before they become invasive. The increased use of abdominal imaging has led to a higher rate of identifying pancreatic cysts, but currently it is not possible to accurately determine which cysts have high malignant potential and should be removed. Our previous work showed that the glycosylation and abundance of specific proteins in the cyst fluid was significantly different between potentially malignant cysts and benign cysts, providing leads for biomarkers to guide patient management. In this work we tested the hypothesis that a panel of specific protein glycoforms forms an accurate biomarker for pancreatic cysts with high malignant potential. Using antibody-lectin sandwich arrays, screens of nearly 100 different candidate markers and multiple glycoforms of each marker confirmed previous results and also showed that two distinct glycan structures are present on several proteins at high levels in the cyst fluid of cancer precursors (intraductal pancreatic mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN)) but not in benign cysts (serous cystadenomas (SC) and pseudocysts (PC)). The glycans, N-acetyl glucosamine and the blood group H structure, previously have not been recognized as cancer biomarkers. A six-marker panel comprising the measurement of one of these glycans on MUC5AC, MUC16, endorepellin, and fibronectin correctly detected 37 of 39 (95%) potential cancer precursors and 16 of 18 (89%) of the benign cysts. This performance significantly surpasses current diagnostic accuracy. The validation of this biomarker panel could lead to more accurate treatment decisions for patients with potentially malignant cysts while sparing patients with benign cysts from unnecessary procedures. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4555. doi:1538-7445.AM2012-4555
Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL‐22 production and IL‐2‐dependent proliferation (2015)

Death receptor 3 (DR3, TNFRSF25) is expressed by activated lymphocytes and signaling by its ligand, TL1A, enhances cytokine expression and proliferation. Recent studies show that DR3 is also present on murine type 2 innate lymphoid cells (ILC2s). Here, we show that DR3 is expressed by IL-22-producing human group 3 innate lymphoid cells (ILC3s). Stimulation of ILC3s with exogenous TL1A alone had no impact on cytokine production or proliferation. Addition of TL1A to IL-1β + IL-23 significantly enhanced the amount IL-22 produced by ILC3s as well as the percentage IL-22- and IL-8-producing cells. Addition of TL1A to IL-1β + IL-23 also augmented ILC3 proliferation. Mechanistically, this occurred through the upregulation of CD25 and responsiveness to IL-2 stimulation. The combination of TL1A, IL-1β+ IL-23, and IL-2 expanded ILC3s while IL-1β+ IL-23 did not increase proliferation above controls. After 2 weeks of expansion, ILC3s maintained their phenotype, transcription factor expression, and function (IL-22 production). These findings identify DR3 as a costimulatory molecule on ILC3s that could be exploited for ex vivo expansion and clinical use.
<b>A New Class of Stable Phosphonitrilic Acid Esters. Polyfluoroalkyl Phosphonitrilates</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Class of Stable Phosphonitrilic Acid Esters. Polyfluoroalkyl PhosphonitrilatesRudi. Ratz, Hansjuergen. Schroeder, Henri. Ulrich, Ehrenfried. Kober, and Christoph. GrundmannCite this: J. Am. Chem. Soc. 1962, 84, 4, 551–555Publication Date (Print):February 1, 1962Publication History Published online1 May 2002Published inissue 1 February 1962https://pubs.acs.org/doi/10.1021/ja00863a011https://doi.org/10.1021/ja00863a011research-articleACS PublicationsRequest reuse permissionsArticle Views120Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Galanin receptor subtypes 1 and 2 as therapeutic targets in head and neck squamous cell carcinoma (2010)

GALR1 and GALR2 act as tumor suppressors in HNSCC, in a p53-independent manner. The current data suggest that GALR1 and GALR2 are potentially significant therapeutic targets and prognostic factors in HNSCC.
Pemetrexed in Malignant Pleural Mesothelioma (2005)

Pemetrexed in combination with cisplatin was approved by the FDA on February 4, 2004 for the treatment of patients with MPM whose disease is either unresectable or who are otherwise not candidates for curative surgery. The recommended dose of pemetrexed is 500 mg/m(2) intra venous infusion over 10 minutes on day 1 of each 21-day cycle in combination with 75 mg/m(2) cisplatin infused over 2 hours beginning 30 minutes after the pemetrexed infusion. Patients must receive oral folic acid and vitamin B(12) injections before the start and during therapy to reduce severe toxicities. Patients should also receive corticosteroids with the chemotherapy to decrease the incidence of skin rash. Approval was based on a demonstration of survival improvement in a single randomized trial. Response rates and time to tumor progression were not included in product labeling because of inconsistencies in assessments among the investigators, independent radiologic reviewers, and the FDA, reflecting the difficulty of radiographic assessments in malignant mesothelioma. Complete prescribing information is available on the FDA Web site at http://www.fda.gov/cder/approval/index.htm.
Viscosity and Formaldehyde Consumption of Procyanidin Solutions (1989)

The last decade has seen quite remarkable advances in our knowledge of the structure and properties of the proanthocyanidins. Viscosity measurements were made of solutions of procyanidins isolated from Theobroma cacao and Chaenomeles speciosa with number-average degrees of polymerization of 6.1 and 11.8, respectively, in water and 1% sodium hydroxide at 25 °C. Procyanidins are apparently completely crosslinked by formaldehyde up to a chain length of 6 units, but few units are crosslinked in polymeric procyanidins. The second order rate constants observed for the formaldehyde reaction with catechin or epicatechin are approximately six times higher than that observed for the C. speciosa polymer.
Recommender System Framework Using Clustering and Collaborative Filtering (2010)

Collaborative filtering is becoming greatly popular as it contributes in reducing information overload. Collaborative filtering based recommender system focuses on predicting new items of interest for a user based on correlations computed between that user and other users. In this paper we propose a framework based on, application of data partitioning/clustering algorithm on ratings dataset followed by collaborative filtering for developing a Movie Recommender System. The proposed system reduces the computation time considerably and increases the prediction accuracy.
Spectrum sensing in cognitive femto base stations using welch periodogram (2011)

Reliable spectrum sensing is one of the key technologies for enabling cognitive communications. In this paper, spectrum sensing based on Welch periodogram is applied to a femtocell scenario where cognitive femto base station (FBS) is located in the same frequency band as the surrounding macrocell and neighboring femtocells. Parameters for the femtocell simulations are selected based on 3G Partnership Project (3GPP) contributions to tie this work to on-going femtocell standardization work. Different interference scenarios are also discussed. Spectrum sensing based on Welch periodogram is presented, and two scenarios including a user equipment (UE) located indoor and outdoor are selected for further study. The results, given as receiver operation characteristic (ROC) curves, clarify the practical regions inside of which spectrum sensing is capable of providing reliable results for sensing the presence of the MUE.
Steeping of Poor Quality Wheat. Effects on Physicochemical Properties and Functional Characteristics of the Starch (1982)

Abstract Wheat of poor baking quality was steeped at temperatures ranging from 5° to 50°C, prior to starch isolation. Physicochemical properties of starch – susceptibility to α‐amylase, Amylograph viscosity, and solubility in dimethylsulfoxide – and functional properties – bread and cake baking performance and thickening power – were determined. Starch yield increased as the steeping temperature increased. The susceptibility of starches to α‐amylase increased significantly as the steeping temperature of grain increased above 40 °C. Amylograph consistency of starches increased due to temperature of steeping. Increasing the steeping temperature of grain increased starch solubility in dimethyl sulfoxide. Bread baking performance of starches was not significantly affected by the various treatment temperatures and bread of satisfactory quality was obtained. Cakes of very good characteristics were produced with all starches. The thickening power of starches in fillings stored at room and refrigeration temperatures was higher initially for starches isolated at higher temperature. The consistency decreased upon storage in all fillings. Starch with acceptable functional properties could be obtained from a wheat of poor baking quality.
Facile Preparation of Complex Protein Architectures with Sub‐100‐nm Resolution on Surfaces (2007)

Ink, subtract, print: A novel method is developed for patterning proteins into complex architectures with high resolution, high contrast, and self-alignment (see fluorescence micrographs). An elastomer is inked with proteins, and a nanotemplate is used to selectively subtract proteins, leaving a pattern that is then printed onto a substrate. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700989_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Experimental and theoretical investigations of a rectangular grating structure for low-voltage traveling wave tube amplifiers (1997)

A periodic, rectangular grating slow-wave-structure is considered for forward and backward wave low-voltage (⩽10 kV) Ku-band traveling wave tube (TWT) amplifiers. For forward wave operation, it is required that the ratio of groove depth, d, to grating period, p, be large (i.e. d/p⩾5) while small values of d/p allow backward wave operation. For large d/p, skin effect losses in the grating slots are large and can substantially reduce the growth rate produced by the beam-slow wave interaction. Phase and amplitude measurements of the grating structures utilizing a slotted line and a fast Fourier transform (FFT) analysis have been carried out. The results show that the measured dispersion relations for both shallow (d/p= 0.446) and deep groove gratings (d/p= 7.43) agree very well with the theoretical dispersion relations. For amplifier experiments, a round “probe” beam (10 kV, 0.25 A, 1 mm radius) from a Litton Pierce electron gun (model M707) is utilized. The beam is confined by means of a 1 kG focusing solenoidal magnetic field. Tuning curve and single particle backward wave gain measurements are presented and discussed.
A low-power low-noise sensor IC (2004)

An IC for acquisition of 16 electrophysiology signals in mice is described. Each channel includes programmable gains from 10 to 1000, a 7 kHz low-pass 4th-order Butterworth filter and a sample and hold. Simulations predict 14-bit accuracy up to 7 kHz. The integrated noise from 1 Hz to 7 kHz is 1.9 /spl mu/V/Hz/sup 1/2 /. The +/-0.3V dc input offset of each channel is cancelled with 7-bit DACs controlling the bulk of the first opamp input transistors and 6-bit DACs on the 2/sup nd/ stage. Total power dissipation is 13.5 mW using a 3V supply. Die area is 6 mm/sup 2/ in a 0.25 /spl mu/ process.
Novel markers of normal and neoplastic human plasmacytoid dendritic cells (2008)

Plasmacytoid dendritic cells (pDCs) are involved in innate immunity (eg, by secreting interferons) and also give rise to CD4+CD56+ hematodermic neoplasms. We report extensive characterization of human pDCs in routine tissue samples, documenting the expression of 19 immunohistologic markers, including signaling molecules (eg, BLNK), transcription factors (eg, ICSBP/IRF8 and PU.1), and Toll-like receptors (TLR7, TLR9). Many of these molecules are expressed in other cell types (principally B cells), but the adaptor protein CD2AP was essentially restricted to pDCs, and is therefore a novel immunohistologic marker for use in tissue biopsies. We found little evidence for activation-associated morphologic or phenotypic changes in conditions where pDCs are greatly increased (eg, Kikuchi disease). Most of the molecules were retained in the majority of pDC neoplasms, and 3 (BCL11A, CD2AP, and ICSBP/IRF8) were also commonly negative in leukemia cutis (acute myeloid leukemia in the skin), a tumor that may mimic pDC neoplasia. In summary, we have documented a range of molecules (notably those associated with B cells) expressed by pDCs in tissues and peripheral blood (where pDCs were detectable in cytospins at a frequency of <1% of mononuclear cells) and also defined potential new markers (in particular CD2AP) for the diagnosis of pDC tumors.
A Study of the MPEG Surround Quality Versus Bit-Rate Curve (2007)

MPEG Surround provides unsurpassed multi-channel audio compression efficiency by extending a mono or stereo audio coder with additional side information. This compression method has two important advantages. The first is its backward compatibility, which is important when MPEG Surround is employed to upgrade an existing service. Secondly, the amount of side information can be varied over a wide range to enable high-quality multi-channel audio compression at extremely low bit rates up to perceptual transparency at higher bit rates. The present paper provides a study of the performance of MPEG Surround, highlighting the various tradeoffs that are available when using MPEG Surround. Furthermore, a quality versus bit rate curve describing the MPEG Surround performance will be presented.
LIV.—The introduction of the chloromethyl group into the aromatic nucleus (1920)

H. Stephen, W. F. Short and G. Gladding, J. Chem. Soc., Trans., 1920, 117, 510 DOI: 10.1039/CT9201700510
Effects of annealing and substrate orientation on epitaxial growth of GaAs on Si (2009)

GaAs thin films grown on Si (100) and (111) substrates by metal-organic chemical vapor deposition were investigated by electron microscopy. It was found that the growth rate of the GaAs epitaxial layers on Si (100) was faster than that on Si (111) due to a lower Si (111) surface energy. The morphologies and internal crystal structure quality of GaAs films grown on Si (111) were better than those grown on Si (100). It was also found that postannealing at high temperature can improve the morphology of the epitaxial layer surface and reduce lattice defects in the thin films.
Estimating Word Translation Probabilities from Unrelated Monolingual Corpora Using the EM Algorithm (2000)

Selecting the right word translation among several options in the lexicon is a core problem for machine translation. We present a novel approach to this problem that can be trained using only unrelated monolingual corpora and a lexicon. By estimating word translation probabilities using the EM algorithm, we extend upon target language modeling. We construct a word translation model for 3830 German and 6147 English noun tokens, with very promising results. 1. Introduction Selecting the right word translation among several options in the lexicon is a core problem for machine translation. The problem is related to word sense disambiguation, which tries to determine the correct sense for a word occurrence (e.g. river bank vs. money bank). While the definition of word sense is a tricky issue, the picture is much clearer in translation. If we observe human translators, we can collect up the different ways in which a German word is usually translated into English. In some contexts, ...
Effect of various hexoses on sperm capacitation and penetration of rat eggs <i>in vitro</i> (1978)

Fertilization of rat eggs in vitro could not be achieved when epididymal spermatozoa were preincubated and eggs in clots incubated in a chemically defined medium without D-glucose. Very high proportions (84-100%) of eggs examined were undergoing fertilization when 2.78-8.34 mM-D-glucose were included in the medium. The substitution of D-fructose or D-galactose for D-glucose resulted in very poor penetration rates (0-4%), but D-mannose was effective for fertilization (59-99% penetration). Incubations for sperm capacitation and egg fertilization in different media containing the various hexoses showed that rat epididymal spermatozoa could be partly capacitated without hexose, that D-glucose, D-mannose or D-galactose but not D-fructose is effective for sperm capacitation and that only D-glucose and D-mannose supported penetration of eggs in vitro.
Protein Kinase C-δ (PKC-δ) Is Activated by Type I Interferons and Mediates Phosphorylation of Stat1 on Serine 727 (2002)

It is well established that engagement of the Type I interferon (IFN) receptor results in activation of JAKs (Janus kinases), which in turn regulate tyrosine phosphorylation of STAT proteins. Subsequently, the IFN-dependent tyrosine-phosphorylated/activated STATs translocate to the nucleus to regulate gene transcription. In addition to tyrosine phosphorylation, phosphorylation of Stat1 on serine 727 is essential for induction of its transcriptional activity, but the IFNalpha-dependent serine kinase that regulates such phosphorylation remains unknown. In the present study we provide evidence that PKC-delta, a member of the protein kinase C family of proteins, is activated during engagement of the Type I IFN receptor and associates with Stat1. Such an activation of PKC-delta appears to be critical for phosphorylation of Stat1 on serine 727, as inhibition of PKC-delta activation diminishes the IFNalpha- or IFNbeta-dependent serine phosphorylation of Stat1. In addition, treatment of cells with the PKC-delta inhibitor rottlerin or the expression of a dominant-negative PKC-delta mutant results in inhibition of IFNalpha- and IFNbeta-dependent gene transcription via ISRE or GAS elements. Interestingly, PKC-delta inhibition also blocks activation of the p38 MAP kinase, the function of which is required for IFNalpha-dependent transcriptional regulation, suggesting a dual mechanism by which this kinase participates in the generation of IFNalpha responses. Altogether, these findings indicate that PKC-delta functions as a serine kinase for Stat1 and an upstream regulator of the p38 MAP kinase and plays an important role in the induction of Type I IFN-biological responses.
Imaging deoxyribose nucleic acid molecules on a metal surface under water by scanning tunneling microscopy (1988)

We have investigated the mechanism of a scanning tunneling microscope operated in air and water by measuring current–distance (It–s) characteristics and making spatial maps of dIt/ds, for Pt and W tips and gold substrates. Although the It–s curves are characteristic of tunneling, their interpretation in terms of work functions would require values between a few tenths of and a few thousandths of the vacuum values. These values do not depend on the metals or the tunneling medium. We conclude that the tip and substrate are always in contact via an insulating adsorbate layer. We prepare flat, clean gold surfaces onto which we can form stable aggregates of DNA molecules under a buffer solution in a small electrochemical cell by a cycle of plating followed by stripping. The aggregates are imaged both as depressions in a constant-current topology map, and dramatic changes on a dIt/ds map. 20-Å corrugations are clearly visible in dense aggregates of high molecular weight DNA which appear to pack with liquid–crystalline order. On occasion the path of an individual molecule can be followed.
694. The synthesis of some acylglycines and related oxazolones (1960)

R. M. Acheson, D. A. Booth, R. Brettle and A. M. Harris, J. Chem. Soc., 1960, 3457 DOI: 10.1039/JR9600003457
Optical Tracking Telemetry and Commanding (TT&C) for Small Satellites (1999)

This paper presents information on the current state of technology and potential subsystem and operational concepts to allow the use of low power optical communication systems to perform tracking, telemetry and commanding (IT &C) for small satellites. The mantra of 'smaller, faster, better (& cheaper)' has been realized, at least partially, for many aspects of small satellite design, construction and operations. Most small spacecraft systems have become smaller, lighter and more power efficient while offering greater performance. Unfortunately, one area that has not followed this general trend is IT &C. In many ways, this situation takes on greater significance due to the successes in other areas relating to processors, memory and sensor capability. Technology improvements in these areas have increased the capabilities of small satellites to collect, process and store data on-board the satellite to such a point that the ability of the spacecraft to generate data has outpaced its ability to communicate it to the ground. One approach to resolving this situation is to make use of optical communications technology for IT&C.
800 MHz Band Face-Bonding Filter Using Dielectric B. D. l. S. (2005)

A 800MHz band face-bonding bandpass filter using high K dielectric "Balanced Double Layered Stripline (B. D. L. S.)" construction was developed. This construction suppressed RF leakage almost completely. And excellent temperature stability as high as the dielectric material was obtained. The insertion loss was improved over 20% compared with the conventional microstripline filter. Outer dimensions of the 5-pole filter were 27x11x5mm.