gebhart/patrepeval huggingface dataset:
Synthesis, chemistry, and properties of a monoalkylated buckminsterfullerene derivative, tert-BuC60 anion (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, chemistry, and properties of a monoalkylated buckminsterfullerene derivative, tert-BuC60 anionPaul J. Fagan, Paul J. Krusic, Dennis H. Evans, Susan A. Lerke, and Eric JohnstonCite this: J. Am. Chem. Soc. 1992, 114, 24, 9697–9699Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://doi.org/10.1021/ja00050a081RIGHTS & PERMISSIONSArticle Views726Altmetric-Citations200LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (440 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The Zone Plate as a Television Test Pattern (1979)

The zone plate pattern is a two-dimensional linear sweep of spatial frequency which can be used to give a quick appraisal of a television system's frequency characteristics. Applications discussed include measurement of filter characteristics, source and display properties, sub-Nyquist sampling system impairments, PAL coding and decoding, and standards conversion. The pattern can be generated electronically in both circular and hyperbolic form, although the latter is simpler and the circuit diagram of such a generator is provided.
Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms: a Chinese multi-center study. (2010)

We found that stimulatory foods, anorectal disease and caffeine beverages are potential risk factors for IC/PBS. Further studies are necessary to determine their role in the pathogenesis of this disorder.
Quantitative assessment of myocardial perfusion defects with real-time three-dimensional myocardial contrast echocardiography. (2006)

RT3DE with myocardial contrast opacification could accurately estimate underperfused myocardial mass in dogs of acute coronary occlusion and would play an important role in quantitative assessment of myocardial perfusion defects in patients with coronary artery disease.
Harvesting of <i>Scenedesmus obliquus</i> in wastewaters: Auto‐ or bioflocculation? (1987)

Autoflocculation and bioflocculation are considered to be the most promising means for the economical harvesting of microalgae. We have therefore studied these phenomena with cultures of Scenedesmus obliquus produced during biological tertiary wastewater treatment. The quantity of extracellular polymers produced during ageing of the cultures proved insufficient to initiate bio-flocculation while the concentration of Ca(2+) and PO(4) (3-) of the treated effluent were too low to induce autoflocculation. It has been shown, however, that the algae sediment more readily upon ageing, possibly as a result of increased cell density. The use of density gradients made with Percoll (a colloidal solution of silica particles) allowed measurement of the true cell density and showed that this increases when cultures enter the declining growth phase. The quality of the biomass thus harvested is, however, considerably impaired, protein content decreasing from 62.7% (dry wt) during the exponential growth phase (day 5) to 14% at the end of cultures (day 21).
Serine Protease Inhibitor Serp-1 Strongly Impairs Atherosclerotic Lesion Formation and Induces a Stable Plaque Phenotype in ApoE <sup>−/−</sup> Mice (2003)

The myxoma virus protein Serp-1 is a member of the serine protease inhibitor superfamily. Serp-1 potently inhibits human serum proteases including plasmin, urokinase-type plasminogen activator (uPA), and tissue-type plasminogen activator (tPA). Serp-1 also displays a high antiinflammatory activity, rendering it a promising candidate for antiatherosclerotic therapy. In this study, we have thus examined the effect of Serp-1 on de novo atherosclerotic plaque formation and on advanced lesions. Perivascular collars were placed around carotid arteries of ApoE-/- mice to induce atherosclerotic plaques and Serp-1 treatment started at week 1 and week 5 after collar placement. Effects of Serp-1 on de novo atherogenesis were characterized by a significantly lower plaque size than that of control mice (18+/-5x10(3) versus 57+/-12x10(3) microm2, respectively; P=0.007). Immunostaining showed a 50% (P=0.004) decrease in the MOMA-2-stained lesion area of Serp-1-treated mice. Treatment of advanced lesions with Serp-1 resulted in a decrease in plaque size and lumen stenosis (P=0.028). Alpha-actin staining of these lesions was significantly increased compared with the control (P=0.017). In both studies, a higher cellularity of the plaque and increased collagen content was observed in Serp-1-treated mice. In vitro studies showed that Serp-1 induces proliferation and migration of vascular smooth muscle cells. In conclusion, Serp-1 inhibits carotid artery plaque growth and progression in ApoE-/- mice. Equally relevant, it enhances cellularity of the plaque core potentially leading to improved plaque stability. The above results indicate that Serp-1 constitutes a promising lead in antiatherosclerotic therapy.
Selective Blockade of TNFR1 Improves Clinical Disease and Bronchoconstriction in Experimental RSV Infection (2020)

Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis in infants and young children. Although some clinical studies have speculated that tumor necrosis factor (TNF)-α is a major contributor of RSV-mediated airway disease, experimental evidence remains unclear or conflicting. TNF-α initiates inflammation and cell death through two distinct receptors: TNF-receptor (TNFR)1 and TNFR2. Here we delineate the function of TNF-α by short-lasting blockade of either receptor in an experimental BALB/c mouse model of RSV infection. We demonstrate that antibody-mediated blockade of TNFR1, but not TNFR2, results in significantly improved clinical disease and bronchoconstriction as well as significant reductions of several inflammatory cytokines and chemokines, including IL-1α, IL-1β, IL-6, Ccl3, Ccl4, and Ccl5. Additionally, TNFR1 blockade was found to significantly reduce neutrophil number and activation status, consistent with the concomitant reduction of pro-neutrophilic chemokines Cxcl1 and Cxcl2. Similar protective activity was also observed when a single-dose of TNFR1 blockade was administered to mice following RSV inoculation, although this treatment resulted in improved alveolar macrophage survival rather than reduced neutrophil activation. Importantly, short-lasting blockade of TNFR1 did not affect RSV peak replication in the lung. This study suggests a potential therapeutic approach for RSV bronchiolitis based on selective blockade of TNFR1.
Electron lambda-tomography (2009)

Filtered back-projection and weighted back-projection have long been the methods of choice within the electron microscopy community for reconstructing the structure of macromolecular assemblies from electron tomography data. Here, we describe electron lambda-tomography, a reconstruction method that enjoys the benefits of the above mentioned methods, namely speed and ease of implementation, but also addresses some of their shortcomings. In particular, compared to these standard methods, electron lambda-tomography is less sensitive to artifacts that come from structures outside the region that is being reconstructed, and it can sharpen boundaries.
Transforming Growth Factor β and Monocyte Chemotactic Protein-1 Are Elevated in Cerebrospinal Fluid of Immunocompromised Patients with HIV-1 Infection (2004)

Monocyte infiltration of the brain is central to the pathogenesis of HIV-1 encephalitis. The cytokines promoting recruitment of monocytes into the central nervous system during HIV-1 infection are not established. In this study, we evaluated human cerebrospinal fluid from patients with HIV-1 infection for transforming growth factor beta1 (TGFbeta1) and monocyte chemotactic protein-1 (MCP-1) using a quantitative sandwich enzyme-linked immunoassays. Cytokine levels were compared to those from patients with multiple sclerosis and normal controls. In cerebrospinal fluid of patients with HIV-1 infection and CD4<500 cells/mm3, both TGFbeta1 and MCP-1 were significantly elevated compared to those with CD4>500 cells/mm3, multiple sclerosis, and controls.
Ultrasonic microstreaming and related phenomena. (1982)

It has been shown in recent work that biological cells and tissues are affected by low intensity ultrasound in the lower megahertz frequency range if small gas-filled channels or pores are present, with dimensions in the range of a few microns. When these gas bodies pulsate in response to the ultrasound they act on surrounding media by unique forms of radiation pressure, forces and torque; in liquids small-scale eddying is generated, known as microstreaming. It is probably by combinations of these phenomena that biological effects are produced.
Deck heaving Kalman filter estimation and prediction using vision detection (2010)

Based on the data acquiring and processing problem of active undulation compensation,propose a deck heaving Kalman filter estimation and prediction using vision detection.The method can measure the deck heaving value by binocular stereo vision camera system,and predict the next position with Kalman filtering estimation and provide the real-time data as well as predictive value for the active undulation compensation system.The experiment shows that,the error between real data and predict data is not beyond 30%,which can satisfied the requirement that real-time predict data provided to active undulation compensation system.
Enhancement of Naringenin Bioavailability by Complexation with Hydroxypropoyl-β-Cyclodextrin (2011)

The abundant flavonoid aglycone, naringenin, which is responsible for the bitter taste in grapefruits, has been shown to possess hypolipidemic and anti-inflammatory effects both in vitro and in vivo. Recently, our group demonstrated that naringenin inhibits hepatitis C virus (HCV) production, while others demonstrated its potential in the treatment of hyperlipidemia and diabetes. However, naringenin suffers from low oral bioavailability critically limiting its clinical potential. In this study, we demonstrate that the solubility of naringenin is enhanced by complexation with β-cyclodextrin, an FDA approved excipient. Hydroxypropoyl-β-cyclodextrin (HPβCD), specifically, increased the solubility of naringenin by over 400-fold, and its transport across a Caco-2 model of the gut epithelium by 11-fold. Complexation of naringenin with HPβCD increased its plasma concentrations when fed to rats, with AUC values increasing by 7.4-fold and C(max) increasing 14.6-fold. Moreover, when the complex was administered just prior to a meal it decreased VLDL levels by 42% and increased the rate of glucose clearance by 64% compared to naringenin alone. These effects correlated with increased expression of the PPAR co-activator, PGC1α in both liver and skeletal muscle. Histology and blood chemistry analysis indicated this route of administration was not associated with damage to the intestine, kidney, or liver. These results suggest that the complexation of naringenin with HPβCD is a viable option for the oral delivery of naringenin as a therapeutic entity with applications in the treatment of dyslipidemia, diabetes, and HCV infection.
An ‘elaborated’ pseudoknot is required for high frequency frameshifting during translation of HCV 229E polymerase mRNA (1993)

The RNA polymerase gene (gene 1) of the human coronavirus 229E is approximately 20 kb in length and is located at the 5' end of the positive-strand genomic RNA. The coding sequence of gene 1 is divided into two large open reading frames, ORF1a and ORF1b, that overlap by 43 nucleotides. In the region of the ORF1a/ORF1b overlap, the genomic RNA displays two elements that are known to mediate (-1) ribosomal frameshifting. These are the slippery sequence, UUUAAAC, and a 3' pseudoknot structure. By introducing site-specific mutations into synthetic mRNAs, we have analysed the predicted structure of the HCV 229E pseudoknot and shown that besides the well-known stem structures, S1 and S2, a third stem structure, S3, is required for a high frequency of frameshifting. The requirement for an S3 stem is independent of the length of loop 2.
The contribution of blast cell properties to outcome variation in acute myeloblastic leukemia (AML) (1982)

The blast cell population in AML includes progenitors capable of colony formation in culture. Certain properties of these progenitors have been determined, including their capacity for self-renewal and their sensitivities to the chemotherapeutic drugs cytosine arabinoside (Ara- C) and adriamycin (Adria). Wide patient to patient variation was found in these properties, although they were stable during the course of the disease in each patient. We tested the properties, together with clinical risk factors, as attributes contributing to the variation in remission induction and survival. As univariate parameters, self- renewal and Ara-C sensitivity contributed to remission induction, but only self-renewal was related to survival. In multivariate analysis, self-renewal, age and percentage blasts in the marrow contributed to outcome variation; drug sensitivities were not significant. We conclude that self-renewal, a biological property of malignant AML clones, although measured in culture, plays a significant role in determining response to treatment and survival in AML.
Separation of Isomeric Dimethylnaphthalene Mixture in Supercritical Carbon Dioxide by Using Zeolite (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeparation of Isomeric Dimethylnaphthalene Mixture in Supercritical Carbon Dioxide by Using ZeoliteYoshio Iwai, Hirohisa Uchida, Yasuhiko Mori, Hidenori Higashi, Tomohiro Matsuki, Takeshi Furuya, Yasuhiko Arai, Koji Yamamoto, and Yutaka MitoCite this: Ind. Eng. Chem. Res. 1994, 33, 9, 2157–2160Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://doi.org/10.1021/ie00033a019Request reuse permissionsArticle Views116Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (403 KB) Get e-Alertsclose Get e-Alerts
Synthesis and Characterization of the First Pair of an Unlocked and a Locked Self-inclusion Complex from a Permethylated α-Cyclodextrin Derivative (2003)

Abstract To examine self-inclusion phenomena, we intentionally synthesized the first pair of an unlocked and a locked self-inclusion complex, 3h and 4h, from a permethylated α-cyclodextrin-azobenzene dyad through an m-xylylene spacer. A d2-labeled complex 4d was also prepared for decisive 1H NMR spectral assignments. In both complexes, the guests were bound in the CD cavities in a similar manner, whereas the mutual orientation of the spacer and the nearest benzene ring was unexpectedly different.
Fine-tuning scaffolds for tissue regeneration: effects of formic acid processing on tissue reaction to silk fibroin (2010)

Formic acid (FA) plays a key role in the preparation of silk fibroin (SF) scaffolds from cocoons of Bombyx mori and is used for fibre distribution. In this study, we used a subcutaneous implantation model in Wistar rats to examine SF scaffolds prepared by treating the degummed cocoon with FA for either 30 or 60 min. The tissue reaction and inflammatory response to SF was assessed by qualitative histology at intervals from 3 to 180 days. Additionally, dynamic biomaterial-induced vascularization and biomaterial degradation were quantified using a technique for analysing an image of the entire implanted biomaterial. Varying the FA treatment time led to different scaffold morphologies and resulted in two distinct peri-implant tissue reactions. The 30 min-treated scaffold was integrated into the surrounding tissue beginning at day 3 after implantation and vascularization increased 10-fold from 15 to 180 days, while the scaffold was continuously degraded throughout the first 90 days. In contrast, the 60 min-treated SF scaffold appeared as bulk for the first 90 days after implantation, after which a rapid degradation and vascularization process began. After 180 days, the tissue response was similar for both scaffolds, with eventual formation of a well vascularized connective tissue integrating the SF fibres. This study indicates that by modifying the FA treatment time, the tissue reaction to SF scaffolds can be tailored for different tissue-engineering applications. The tunability and biocompatibility of SF make it an attractive scaffold for exploration in regenerative medicine and clinical tissue engineering.
Adenylate control of respiration in plants: the contribution of rotenone‐insensitive electron transport to ADP‐limited oxygen consumption by soybean mitochondria (1990)

The aim was to test the hypothesis that rotenone‐insensive electron transport (bypass of complex I) may underlie rapid state 4 (ADP‐limited) mitochondrial respiration. A comparison of mitochondria from soybean ( Glycine max L. cv. Bragg) cotyledons and nodules showed that ADP‐sufficient (state 3) malate plus pyruvate oxidation by mitochondria from 7‐day‐old cotyledons was inhibited 50% by rotenone and state 4 rates were rapid, whereas nodule mitochondria were 80% inhibited by rotenone and had slower state 4 rates of malate plus pyruvate oxidation. Respiration of malate alone (pH 7.6) by cotyledon mitochondria was slow, especially in the absence of ADP; subsequent addition of pyruvate dramatically increased state 4 oxygen uptake concomitant with a rapid rise in mitochondrial NADH (determined by fluorimetry). Rotenone had no effect on this increased rate of state 4 respiration. The rate of malate oxidation by nodule mitochondria was relatively rapid compared with cotyledon mitochondria. The addition of pyruvate in state 4 caused a slow increase in matrix NADH and only a slight stimulation of oxygen uptake. Rotenone inhibited state 4 malate plus pyruvate oxidation by 50% in these mitochondria. From a large number of cotyledon and nodule mitochondrial preparations, a close correlation was found between the rate of state 4 oxygen uptake and rotenone‐resistance. During cotyledon development increased rotenone‐resistance was associated with an increase in the alternative oxidase. Addition of pyruvate to cotyledon mitochondria, during state 4 oxidation of malate in the presence of antimycin A, significantly stimulated O 2 uptake and also almost eliminated respiratory control. Such combined operation of the rotenone‐insensitive bypass and the alternative oxidase in vivo will significantly affect the extent to which adenylates control the rate of electron transport.
ChemInform Abstract: Carbonyl Coupling Reactions Catalytic in Titanium and the Use of Commercial Titanium Powder for Organic Synthesis. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tunable hydrogel morphology via self-assembly of amphiphilic pentablock copolypeptides (2010)

Hydrogels assembled from symmetric amphiphilic pentablock copolypeptides were investigated using rheology and cryogenic transmission electron microscopy (cryoTEM). Due to the presence of two α-helical hydrophobic segments per chain, the pentablocks have the potential for organized intrachain folding, akin to natural proteins, in addition to intermolecular assembly. We found that variation of the central hydrophilic segment lengths in the copolymers enabled precise tuning of assembly morphology and hydrogel properties. CryoTEM characterization revealed that the hydrogels are nanoporous networks composed of branched and entangled tape-like fibrils, where average fibril length varied with the length of hydrophilic spacer between the hydrophobic domains. The pentablock architecture in these copolymers thus allowed additional control over self-assembled morphology and substantial enhancement of hydrogel properties.
Fast generalized minimum-distance decoding of algebraic-geometry and Reed-Solomon codes (1996)

Generalized minimum-distance (GMD) decoding is a standard soft-decoding method for block codes. We derive an efficient general GMD decoding scheme for linear block codes in the framework of error-correcting pairs. Special attention is paid to Reed-Solomon (RS) codes and one-point algebraic-geometry (AG) codes. For RS codes of length n and minimum Hamming distance d the GMD decoding complexity turns out to be in the order O(nd), where the complexity is counted as the number of multiplications in the field of concern. For AG codes the GMD decoding complexity is highly dependent on the curve in consideration. It is shown that we can find all relevant error-erasure-locating functions with complexity O(o/sub 1/nd), where o/sub 1/ is the size of the first nongap in the function space associated with the code. A full GMD decoding procedure for a one-point AG code can be performed with complexity O(dn/sup 2/).
Synthesis of Natural Product Derivatives Containing 2,4‐Concatenated Oxazoles (2008)

Abstract Herein is described the synthesis of several oxazole‐containing derivatives of IB‐01211. The macrocyclization reaction of peptide 14 containing a concatenated triazole was successful and afforded 3 by amide bond formation. However, for those compounds containing quaterazoles or quinqueazoles, the oxazole ring had to be formed during macrocyclization. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Protein Phosphorylation and Taurine Biosynthesis<i>In Vivo</i>and<i>In Vitro</i> (1997)

Taurine is known to be involved in many important physiological functions. Here we report that both in vivo and in vitro the taurine-synthesizing enzyme in the brain, namely cysteine sulfinic acid decarboxylase (CSAD), is activated when phosphorylated and inhibited when dephosphorylated. Furthermore, protein kinase C and protein phosphatase 2C have been identified as the enzymes responsible for phosphorylation and dephosphorylation of CSAD, respectively. In addition, the effect of neuronal depolarization on CSAD activity and 32P incorporation into CSAD in neuronal cultures is also included. A model to link neuronal excitation and CSAD activation by a Ca2+-dependent protein kinase is proposed.