gebhart/patrepeval huggingface dataset:
The Quality of Pediatric Burn Scars Is Improved by Early Administration of Basic Fibroblast Growth Factor (2006)

Pediatric burn wounds can be problematic because an accurate evaluation is difficult as the result of anatomically immature vasculature or immobilization failure, especially in patients with second-degree burns, and because the burn surface areas and the burn depth tend to worsen over the course of time. Delayed wound healing results in unsightly scarring, such as hypertrophic scars, which are problematic both esthetically and functionally. Among cytokines and growth factors, basic fibroblast growth factor (bFGF) is clinically proven, having demonstrated accelerated acute and chronic wound healing. Accelerated wound healing may lead to improved scarring. To elucidate the effects of bFGF on second-degree pediatric burn wounds, a comparative study was performed. A total of 20 pediatric patients ranging from 8 month to 3 years (average 1 year, 3 months +/- 6 months) who suffered from the burns by various causes were divided into two groups, conventional (n = 10) and treatment with bFGF (n = 10). A moisture meter, used to objectively measure the stratum corneum and epithelial-mesenchymal functions, was used to assess scars at least 1 year after wound healing. Clinical evaluation of pigmentation, pliability, height, and vascularity demonstrated significant differences between conventional and bFGF-treated scars (1.7 +/- 0.55 vs 0.7 +/- 0.58, 2.4 +/- 0.82 vs 1.1 +/- 0.69, 1.8 +/- 0.66 vs 0.5 +/- 0.57, 1.9 +/- 0.63 vs 0.8 +/- 0.68; conventional vs bFGF-treated, pigmentation, pliability, height, and vascularity, respectively, P < .01). The effective contact coefficient was significantly greater in conventional wounds than bFGF-treated wounds (14.6 +/- 1.68 % vs 8.7 +/- 2.82 %; conventional vs bFGF, P < .01) and bFGF-treated wounds demonstrated significantly less transepidermal water loss values than conventional treatment (8.3 +/- 1.90 g/m/h vs 5.7 +/- 1.85 g/m/hr; conventional vs bFGF, P < .01). Pediatric burn patients treated with bFGF showed less damaging function of the stratum corneum after healing both in clinical assessment and moisture meter analysis.
Nonlinear image representation using divisive normalization (2008)

In this paper, we describe a nonlinear image representation based on divisive normalization that is designed to match the statistical properties of photographic images, as well as the perceptual sensitivity of biological visual systems. We decompose an image using a multi-scale oriented representation, and use Student's t as a model of the dependencies within local clusters of coefficients. We then show that normalization of each coefficient by the square root of a linear combination of the amplitudes of the coefficients in the cluster reduces statistical dependencies. We further show that the resulting divisive normalization transform is invertible and provide an efficient iterative inversion algorithm. Finally, we probe the statistical and perceptual advantages of this image representation by examining its robustness to added noise, and using it to enhance image contrast.
Service and system enhancements for TDMA digital cellular systems (1999)

Throughout 1998, the TDMA community investigated and defined an enhanced suite of voice and data services for TIA/EIA-136 while also improving its basic system capabilities. These enhancements, collectively named 136+, provide improved voice quality, increased capacity, higher data rates, and improved tools for RF system engineering. The enhancements are obtained by introducing a new modulation scheme (8-PSK), new slot formats, and the addition of several new interleaving and coding options. As a result, TIA/EIA-136 now supports a new vocoder mode, the GSM enhanced full-rate (US1) for improved fidelity applications, a robust IS-641 vocoder mode with a 4 dB BER enhancement on the IS-136 downlink, and a new packet data service capable of providing usable data rates of 14.4, 28.8, or 43.2 kb/s on a full-rate, double full-rate, or triple full-rate channel, respectively. The packet data service is truly evolutionary in nature, having a new medium access control layer with a network layer very similar to that used for the existing digital control channel. In addition, it maximizes commonalities among TDMA technologies, using identical higher layers and network architecture to the general packet radio service specified in GSM. Furthermore, by using a concept known as tunneling to pass TIA/EIA-136 messages through the GPRS network elements, the existing features defined on the DCCH are maintained. This article provides an overview of these 136+ applications, as well as insight into near-term improvements, such as the ability to support six voice users per 30 kHz (IDMA6), downlink time diversity, and fast power control.
Description of the European Helium-Cooled EFIT Plant: An Industrial-Scale Accelerator-Driven System for Minor Actinide Transmutation—II (2012)

In order to reduce the volume and the radiotoxicity of the nuclear waste coming from the operation of existing pressurized water reactors, accelerator-driven systems (ADSs) have been envisioned.The Helium-cooled (He) European Facility for Industrial-scale Transmutation (He-EFIT) concept is the EUROpean Research Programme for the TRANSmutation of High Level Nuclear Waste in Accelerator Driven System (EUROTRANS) Integrated Project (IP) (EUROTRANS IP) backup option, whereas Pb-cooled EFIT is the reference one. The plant has a power of [approximately]400 MW(thermal). Like all ADS plants, it consists of three main components: the accelerator, the spallation target module, and the subcritical core.This paper describes the He-EFIT design at the end of the EUROTRANS IP as well as the studies performed to support this design: spallation performances, trasmutation capabilities, and plant safety analyses.No specific technology deadlock has been identified, and it might be possible to build such a plant given necessary research and development in support.
Site-specific gene delivery <i>in vivo</i> through engineered Sendai viral envelopes (1998)

Inspite of several stimulating developments in gene therapy, the formulation of a targeted gene delivery "vector" is still far from ideal. We have demonstrated the potential of reconstituted Sendai viral envelopes containing only the fusion glycoprotein (F-virosomes) in targeted delivery of reporter genes to liver cells of BALB/c mouse in vivo. The membrane fusion-mediated high efficiency of gene transfer to liver cells was ascertained following a critical evaluation of the level of the DNA, mRNA, and relevant proteins. Furthermore, the involvement of viral glycoprotein both as a unique natural ligand and as a membrane fusogen could lead to preferential transfection of parenchymal cell types of liver. The integration of transgenes in the mouse chromosomal DNA and its stable expression up to 4 mo after single i.v. administration of this gene carrier has bolstered its efficiency and novelty. Moreover, the F-virosomes did not elicit significant humoral immune response against the fusion protein in the injected animal. The findings reported here open up the possibility for considering "F-virosomes" as a promising "vehicle" for site-specific DNA delivery in gene therapy.
A Biophysical Approach to Transcription Factor Binding Site Discovery (2003)

Identification of transcription factor binding sites within regulatory segments of genomic DNA is an important step toward understanding of the regulatory circuits that control expression of genes. Here, we describe a novel bioinformatics method that bases classification of potential binding sites explicitly on the estimate of sequence-specific binding energy of a given transcription factor. The method also estimates the chemical potential of the factor that defines the threshold of binding. In contrast with the widely used information-theoretic weight matrix method, the new approach correctly describes saturation in the transcription factor/DNA binding probability. This results in a significant improvement in the number of expected false positives, particularly in the ubiquitous case of low-specificity factors. In the strong binding limit, the algorithm is related to the "support vector machine" approach to pattern recognition. The new method is used to identify likely genomic binding sites for the E. coli transcription factors collected in the DPInteract database. In addition, for CRP (a global regulatory factor), the likely regulatory modality (i.e., repressor or activator) of predicted binding sites is determined.
Extended Stokes Shift in Fluorescent Proteins: Chromophore–Protein Interactions in a Near-Infrared TagRFP675 Variant (2013)

Most GFP-like fluorescent proteins exhibit small Stokes shifts (10-45 nm) due to rigidity of the chromophore environment that excludes non-fluorescent relaxation to a ground state. An unusual near-infrared derivative of the red fluorescent protein mKate, named TagRFP675, exhibits the Stokes shift, which is 30 nm extended comparing to that of the parental protein. In physiological conditions, TagRFP675 absorbs at 598 nm and emits at 675 nm that makes it the most red-shifted protein of the GFP-like protein family. In addition, its emission maximum strongly depends on the excitation wavelength. Structures of TagRFP675 revealed the common DsRed-like chromophore, which, however, interacts with the protein matrix via an extensive network of hydrogen bonds capable of large flexibility. Based on the spectroscopic, biochemical, and structural analysis we suggest that the rearrangement of the hydrogen bond interactions between the chromophore and the protein matrix is responsible for the TagRFP675 spectral properties.
High Electron Mobility Thin‐Film Transistors Based on Solution‐Processed Semiconducting Metal Oxide Heterojunctions and Quasi‐Superlattices (2015)

High mobility thin-film transistor technologies that can be implemented using simple and inexpensive fabrication methods are in great demand because of their applicability in a wide range of emerging optoelectronics. Here, a novel concept of thin-film transistors is reported that exploits the enhanced electron transport properties of low-dimensional polycrystalline heterojunctions and quasi-superlattices (QSLs) consisting of alternating layers of In<sub>2</sub>O<sub>3</sub>, Ga<sub>2</sub>O<sub>3,</sub> and ZnO grown by sequential spin casting of different precursors in air at low temperatures (180-200 °C). Optimized prototype QSL transistors exhibit band-like transport with electron mobilities approximately a tenfold greater (25-45 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>) than single oxide devices (typically 2-5 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>). Based on temperature-dependent electron transport and capacitance-voltage measurements, it is argued that the enhanced performance arises from the presence of quasi 2D electron gas-like systems formed at the carefully engineered oxide heterointerfaces. The QSL transistor concept proposed here can in principle extend to a range of other oxide material systems and deposition methods (sputtering, atomic layer deposition, spray pyrolysis, roll-to-roll, etc.) and can be seen as an extremely promising technology for application in next-generation large area optoelectronics such as ultrahigh definition optical displays and large-area microelectronics where high performance is a key requirement.
Fortnightly review: Acute dystonia induced by drug treatment (1999)

Acute dystonia induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs, and it may occur at an early stage of treatment.1 2 Acute dystonia is often frightening and may seriously disturb the relationship between the doctor and the patient. Therefore, every doctor who prescribes dopamine blocking agents should be familiar with the prevalence of and the risk factors for acute dystonia and should know how to prevent and treat the condition.

#### Summary points

Acute dystonia induced by drug treatment can be caused by antipsychotic, antiemetic, and antidepressant drugs

Acute dystonia caused by drug treatment can seriously disturb the relationship between doctor and patient and should be prevented

Patients who develop abnormal positioning or muscle spasms within seven days of starting drug treatment or of a rapid increase in the dose of a drug may be diagnosed with acute, drug induced dystonia

Biperiden 5 mg should be administered intramuscularly to treat the condition; this is nearly always effective within 20 minutes

Risk factors for acute, drug induced dystonia include young age, male sex, use of cocaine, and a history of acute dystonia

Drug induced dystonia can be prevented either by adding, during the first four to seven days of treatment, anticholinergic drugs to treatment with antipsychotic drugs or by starting treatment with atypical antipsychotics

We searched Medline and Embase for the period 1980-98 using the key terms extrapyramidal syndromes, dyskinesia, dystonia, movement disorders, side effects, and antipsychotics, and we checked the reference lists of the articles that we identified. This information supplemented our own research into extrapyramidal side effects induced by antipsychotic drugs.3–5

Acute dystonia induced by antipsychotic drugs is described as “sustained abnormal postures or muscle spasms that develop within seven days of starting or rapidly raising the dose of …
The Challenge of Using Future SWOT Data for Oceanic Field Reconstruction (2015)

Abstract Conventional altimetry measures a one-dimensional profile of sea surface height (SSH) along the satellite track. Two-dimensional SSH can be reconstructed using mapping techniques; however, the spatial resolution is quite coarse even when data from several altimeters are analyzed. A new satellite mission based on radar interferometry is scheduled to be launched in 2020. This mission, called Surface Water and Ocean Topography (SWOT), will measure SSH at high resolution along a wide swath, thus providing two-dimensional images of the ocean surface topography. This new capability will provide a large amount of data even though they are contaminated with instrument noise and geophysical errors. This paper presents a tool that simulates synthetic observations of SSH from the future SWOT mission using SSH from any ocean general circulation model (OGCM). SWOT-like data have been generated from a high-resolution model and analyzed to investigate the sampling and accuracy characteristics of the future SWOT data. This tool will help explore new ideas and methods for optimizing the retrieval of information from future SWOT missions.
Synovial deposition of wild-type transthyretin-derived amyloid in knee joint osteoarthritis patients (2013)

Wild-type TTR-derived amyloid may affect the synovial tissue as a result of long-term mechanical stress or as a part of senile systemic amyloidosis in approximately 8% of knee joint OA patients. No obvious clinical significance was found in synovial deposition of amyloid.
Bond of Lightweight Aggregate Concrete Incorporating Condensed Silica Fume (1986)

Synopsis: Condensed silica fume, at up to 30% by weight, was used as a partial cement replacement in lightweight aggregate concrete. The results of round and deformed bar cube pull-out tests, with and without applied lateral stress, show that condensed silica fume increases ultimate bond strength and affects the mechanism of failure. The influence of condensed silica fume on bond stress of round bars was similar at all lateral stresses, producing a 50% increase at 20% by weight replacement of cement. For deformed bars the increase in bond strength was more pronounced at higher levels of lateral stress, producing increases approaching 70% at 20% silica fume content. The improvements in ultimate bond strength with condensed silica fume are shown to only partly result from the associated increases in compressive strength, the greater part resulting from the modified properties of the concrete matrix.
Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells (2013)

Large-scale codon re-encoding represents a powerful method of attenuating viruses to generate safe and cost-effective vaccines. In contrast to specific approaches of codon re-encoding which modify genome-scale properties, we evaluated the effects of random codon re-encoding on the re-emerging human pathogen Chikungunya virus (CHIKV), and assessed the stability of the resultant viruses during serial in cellulo passage. Using different combinations of three 1.4 kb randomly re-encoded regions located throughout the CHIKV genome six codon re-encoded viruses were obtained. Introducing a large number of slightly deleterious synonymous mutations reduced the replicative fitness of CHIKV in both primate and arthropod cells, demonstrating the impact of synonymous mutations on fitness. Decrease of replicative fitness correlated with the extent of re-encoding, an observation that may assist in the modulation of viral attenuation. The wild-type and two re-encoded viruses were passaged 50 times either in primate or insect cells, or in each cell line alternately. These viruses were analyzed using detailed fitness assays, complete genome sequences and the analysis of intra-population genetic diversity. The response to codon re-encoding and adaptation to culture conditions occurred simultaneously, resulting in significant replicative fitness increases for both re-encoded and wild type viruses. Importantly, however, the most re-encoded virus failed to recover its replicative fitness. Evolution of these viruses in response to codon re-encoding was largely characterized by the emergence of both synonymous and non-synonymous mutations, sometimes located in genomic regions other than those involving re-encoding, and multiple convergent and compensatory mutations. However, there was a striking absence of codon reversion (<0.4%). Finally, multiple mutations were rapidly fixed in primate cells, whereas mosquito cells acted as a brake on evolution. In conclusion, random codon re-encoding provides important information on the evolution and genetic stability of CHIKV viruses and could be exploited to develop a safe, live attenuated CHIKV vaccine.
Examining the function and regulation of hsp 70 in cells subjected to metabolic stress (1992)

Members of the heat-shock protein (hsp) 70 family, distributed within various cellular compartments, have been implicated in facilitating protein maturation events. In particular, related hsp 70 family members appear to bind nascent polypeptides which are in the course of synthesis and/or translocation into organelles. We previously reported that in normal, unstressed cells, cytosolic hsp 70 (hsp 72/73) interacted transiently with nascent polypeptides. We suspect that such interactions function to prevent or slow down the folding of the nascent polypeptide chain. Once synthesis is complete, and now with all of the information for folding present, the newly synthesized protein appears to commence along its folding pathway, accompanied by the ATP-dependent release of hsp 72/73. Herein, we examined how these events occur in cells subjected to different types of metabolic stress. In cells exposed to either an amino acid analog or sodium arsenite, two potent inducers of the stress response, newly synthesized proteins bind to but are not released from hsp 70. Under these conditions of metabolic stress, we suspect that the newly synthesized proteins are unable to commence proper folding and consequently remain bound to their hsp 70 chaperone. In cells subjected to heat shock, a large number of both newly synthesized as well as mature proteins are rendered insoluble. Within this insoluble material are appreciable amounts of hsp 72/73. Finally, we show that in cells depleted of ATP, the release of hsp 70 from maturing proteins is inhibited. Thus, in cells experiencing metabolic stress, newly synthesized proteins unable to properly fold, as will as mature proteins which begin to unfold become stably bound to hsp 72/73. As a consequence and over time, the free or available levels of pre-existing hsp 72/73 are reduced. We propose that this reduction in the available levels of hsp 72/73 is the trigger by which the stress response is initiated.
Directional Neurite Outgrowth Is Enhanced by Engineered Meningeal Cell-Coated Substrates (2005)

After injury to the CNS, the anatomical organization of the tissue is disrupted, posing a barrier to the regeneration of axons. Meningeal cells, a central participant in the CNS tissue response to injury, migrate into the core of the wound site in an unorganized fashion and deposit a disorganized extracellular matrix (ECM) that produces a nonpermissive environment. Previous work in our laboratory has shown that the presentation of nanometer-scale topographic cues to these cells influences their morphological, cytoskeletal, and secreted ECM alignment. In the present study, we provided similar environmental cues to meningeal cells and examined the ability of the composite construct to influence dorsal root ganglion regeneration in vitro. When grown on control surfaces of meningeal cells lacking underlying topographic cues, there was no bias in neurite outgrowth. In contrast, when grown on monolayers of meningeal cells with underlying nanometer-scale topography, neurite outgrowth length was greater and was directed parallel to the underlying surface topography even though there exists an intervening meningeal cell layer. The observed outgrowth was significantly longer than on laminin-coated surfaces, which are considered to be the optimal substrata for promoting outgrowth of dorsal root ganglion neurons in culture. These results suggest that the nanometer-level surface finish of an implanted biomaterial may be used to organize the encapsulation tissue that accompanies the implantation of materials into the CNS. It furthermore suggests a simple approach for improving bridging materials for repair of nerve tracts or for affecting cellular organization at a device-tissue interface.
A distributed self-clocked fair queueing architecture for wireless ATM networks (2002)

The application of asynchronous transfer mode (ATM) to a wireless local area network (WLAN) environment is a new undertaking and poses many problems not found in either wireline ATM or data-only WLAN networks. The WLAN is designed as a centralized network, where a complex base station polls simpler remote stations. A polling algorithm called distributed fair queueing (DFQ) is developed from the self-clocked fair queueing (SCFQ) service discipline. The DFQ protocol allows SCFQ performance in a wireless LAN environment where queue information is not automatically available to the poller. Bounds for delay for certain services are derived explicitly, and other services are shown to be derivable from fair queueing theory. A reasonable service mix is simulated to show delay performance versus system load.