gebhart/patrepeval huggingface dataset:
.epsilon.BP, a .beta.-galactoside-binding animal lectin, recognizes IgE receptor (Fc.epsilon.RI) and activates mast cells (1993)

IgE-binding protein (epsilon BP) was originally identified in rat basophilic leukemia (RBL) cells by virtue of its affinity for IgE. epsilon BP is now known to be a beta-galactoside-binding lectin containing an S-type carbohydrate recognition domain. It is identical to a macrophage surface antigen, Mac-2, and lectins designated as CBP35, L-34, and RL-29, for which various functions have been suggested. Studies from other groups as well as ours have indicated that epsilon BP is secreted by cells such as macrophages and is present in extracellular fluids. We demonstrated previously that binding sites for epsilon BP are present on the surface of RBL cells. In this report, we show that epsilon BP binds to a small number of glycoprotein species on the surface of RBL cells. Significantly, one of these glycoproteins is the high-affinity IgE receptor (Fc epsilon RI). Preliminary studies showed that epsilon BP causes mediator release from RBL cells, possibly through cross-linking of Fc epsilon RI. The results suggest a function of epsilon BP as an activator of mast cells.
Challenges in Atherosclerotic Plaque Characterization With Intravascular Ultrasound (IVUS): From Data Collection to Classification (2008)

In vivo plaque characterization is an important research field in interventional cardiology. We will study the realistic challenges to this goal by deploying 40 MHz single-element, mechanically rotating transducers. The intrinsic variability among the transducers' spectral parameters as well as tissue signals will be demonstrated. Subsequently, we will show that global data normalization is not suited for data calibration, due to the aforementioned variations as well as the stringent characteristics of spectral features. We will describe the sensitivity of an existing feature extraction algorithm based on eight spectral signatures (integrated backscatter coefficient, slope, midband-fit (MBF), intercept, and maximum and minimum powers and their relative frequencies) to a number of factors, such as the window size and order of the autoregressive (AR) model. It will be further demonstrated that the variations in the transducer's spectral parameters (i.e., center frequency and bandwidth) cause inconsistencies among extracted features. In this paper, two fundamental questions are addressed: 1) what is the best reliable way to extract the most informative features? and 2) which classification algorithm is the most appropriate for this problem? We will present a full-spectrum analysis as an alternative to the eight-feature approach. For the first time, different classification algorithms, such as k-nearest neighbors (k-NN) and linear Fisher, will be employed and their performances quantified. Finally, we will explore the reliability of the training dataset and the complexity of the recognition algorithm and illustrate that these two aspects can highly impact the accuracy of the end result, which has not been considered until now.
DNA Methylation Data Analysis and its Application to Cancer Research (2013)

With the rapid development of genome-wide high-throughput technologies, including expression arrays, SNP arrays and next-generation sequencing platforms, enormous amounts of molecular data have been generated and deposited in the public domain. The application of computational approaches is required to yield biological insights from this enormous, ever-growing resource. A particularly interesting subset of these resources is related to epigenetic regulation, with DNA methylation being the most abundant data type. In this paper, we will focus on the analysis of DNA methylation data and its application to cancer studies. We first briefly review the molecular techniques that generate such data, much of which has been obtained with the use of the most recent version of Infinium HumanMethylation450 BeadChip(®) technology (Illumina, CA, USA). We describe the coverage of the methylome by this technique. Several examples of data mining are provided. However, it should be understood that reliance on a single aspect of epigenetics has its limitations. In the not too distant future, these defects may be rectified, providing scientists with previously unavailable opportunities to explore in detail the role of epigenetics in cancer and other disease states.
[Recent progress in non-Hodgkin's lymphoma study in Japan]. (1988)

Great progress has been made in clinical research on non-Hodgkin's lymphoma during the last 15 years. Surface marker and DNA analyses of immunoglobulin and T-cell receptor genes are essential for new classification of the disease according to the cellular origin of tumor cells. This approach resulted in the establishment of new disease entities such as adult T-cell leukemia/lymphoma(ATL), immunoblastic lymphoadenopathy (IBL)-like T-cell lymphoma, and the pleural B-lymphoma occurring in long-standing pyothorax. New retrovirus, HTLV-I, was found during studies on ATL. Prevention of HTLV-I infection is an important project. HTLV-I negative ATL was also found and is of particular interest in understanding leukemogenesis of ATL. An oncogen such as bcl-2 is important for characterization of follicular lymphoma. Prognostic factors of patients with T-lymphoma are completely different from those of B-lymphoma. Risk grouping by combination of major prognostic factors is useful for the selection of the best treatment modality and the accurate estimation of prognosis of patients at initial presentation. The effect of combination chemotherapy should be evaluated separately between T- and B-lymphomas because of the difference in response rate and prognostic factors.
Carbon dioxide laser monitor for NH_3 in flue gas (1983)

An instrument was developed for the detection of NH3 in flue gas, exploiting a fortuitous spectral overlap between the ν2aQ(6,6) absorption line of NH3 and the R (18) emission line of the isotopic 13C16O2 laser. The system was developed for use with De–NOx processes, which convert harmful nitric oxides generated in utility and industrial furnaces into harmless nitrogen and water vapor by injection of NH3. The instrument detects unreacted NH3 in the flue gas down to concentrations of a few ppm with an accuracy of ∼10%. It can serve as an environmental monitor and as part of a feedback control system to adjust the upstream NH3 injection to the desired rate.
Power Simulation and Estimation in VLSI Circuits (1999)

In the past, the major concerns of the VLSI designer were area, speed, and cost power consideration was typically of secondary importance.In recent y ears, however, this has begun to change and, increasingly, p o wer is being given comparable weight to other design considerations.Several factors have c o n tributed to this trend, including the remarkable success and growth of the class of battery-powered, personal computing devices and wireless communications systems that demand highspeed computation and complex functionality w i t h l o w p o wer consumption.In these applications, extending the battery service life is a critical design concern.There also exists a signi cant pressure for producers of high-end products to reduce their power consumption.The main driving factors for lower power dissipation in these products are the cost associated with packaging and cooling as well as the circuit reliability.System designers have started to respond to the requirement o f p o wer-constrained system designs by a c o m bination of architectural improvements and advanced design automation methodologies and technqiues for low p o wer.In parallel, researchers and CAD tool developers have i n troduced a variety of models, algorithms, and techniques for estimating the power dissipation in VLSI circuits and systems in support of the low p o wer optimization and synthesis techniques.This article describes representative contributions to the power modeling and estimation of VLSI circuits at various levels of design abstraction.
Predicting Obesity in Young Adulthood from Childhood and Parental Obesity (1997)

Background Childhood obesity increases the risk of obesity in adulthood, but how parental obesity affects the chances of a child's becoming an obese adult is unknown. We investigated the risk of obesity in young adulthood associated with both obesity in childhood and obesity in one or both parents.
High hopes (2014)

Psychedelic drugs fell from grace in the 1960s. Now, scientists are rediscovering them as potential treatments for a range of illnesses.
Autoimmune Folate Deficiency and the Rise and Fall of “Horror Autotoxicus” (2005)

In 1904, a little more than a century ago, Julius Donath, a senior physician working in the Vienna Merchants' Hospital, and Karl Landsteiner, the chair of the pathology department at the University of Vienna and one of the founders of immunochemistry, reported the first known autoimmune disease in humans, paroxysmal cold hemoglobinuria. They showed that an antibody in this disease reacted in the cold with the patient's own erythrocytes. By definition, the Donath–Landsteiner antibody was an autoantibody. This revolutionary discovery flew in the face of “horror autotoxicus,” a principle that Paul Ehrlich had expounded after failing to find autoantibodies in . . .
Continuous Process for Acetylation of 2 3-Butylene Glycol (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTContinuous Process for Acetylation of 2 3-Butylene GlycolL. E. Schniepp, J. W. Dunning, and E. C. LathropCite this: Ind. Eng. Chem. 1945, 37, 9, 872–877Publication Date (Print):September 1, 1945Publication History Published online1 May 2002Published inissue 1 September 1945https://pubs.acs.org/doi/10.1021/ie50429a023https://doi.org/10.1021/ie50429a023research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Redundant actuator development study (1973)

Current and past supersonic transport configurations are reviewed to assess redundancy requirements for future airplane control systems. Secondary actuators used in stability augmentation systems will probably be the most critical actuator application and require the highest level of redundancy. Two methods of actuator redundancy mechanization have been recommended for further study. Math models of the recommended systems have been developed for use in future computer simulations. A long range plan has been formulated for actuator hardware development and testing in conjunction with the NASA Flight Simulator for Advanced Aircraft.
Substituted Analogues of GV150526 as Potent Glycine Binding Site Antagonists in Animal Models of Cerebral Ischemia (1999)

A series of analogues of the indole-2-carboxylate GV150526, currently in clinical trials as a potential neuroprotective agent for the control of the cerebral damage after stroke onset, was designed based on previous studies dealing with the electronic features of the north-east region of the glycine binding site associated with the NMDA receptor. In particular, the substitution of the para position of the terminal phenyl ring of GV150526 with suitable hydrophilic groups resulted in the identification of a new class of glycine antagonists. These compounds exhibited nanomolar in vitro affinity to the glycine binding site, high receptor selectivity, and outstanding in vivo potency. In particular, 3-[(E)-2-[(4-ureidomethylphenyl)aminocarbonyl]ethenyl]-4, 6-dichloroindole-2-carboxylic acid was found to be highly effective in the middle cerebral artery occlusion (MCAo) model in the rat, an animal model of focal ischemia, when given both prior to and after the occlusion of the middle cerebral artery. Notably, a significant neuroprotective effect was seen in this model postischaemia, when the administration of this compound was delayed up to 6 h from the occlusion of the middle cerebral artery, further confirming the wide therapeutic window seen for GV150526A.
Lipoproteins are substrates for human secretory group IIA phospholipase A2: preferential hydrolysis of acute phase HDL (1998)

Group IIA secretory phospholipase A2 is an acute phase enzyme, co-expressed with serum amyloid A protein. Both are present in atherosclerotic lesions. We report that human normal and acute phase high density lipoproteins and low density lipoprotein are effective substrates for human group IIA phospholipase A2. The enzyme hydrolyzed choline and ethanolamine glycerophospholipids at the sn -2 position resulting in an accumulation of the corresponding lysophospholipids, including the unhydrolyzed alkyl and alkenyl ether derivatives. The hydrolysis of acute phase high density lipoprotein was 2- to 3-fold more rapid and intensive than of normal high density lipoprotein. The hydrolysis of lipoproteins was noted at enzyme concentration as low as 0.05 microgram/mg protein, which was within the range observed in the circulation in acute and chronic inflammatory diseases. The enzyme hydrolyzed the different molecular species of the residual glycerophospholipids in proportion to their mass, showing no preference for the release of arachidonic acid. Group IIA phospholipase A2 preferentially attacked the hydroxy and hydroperoxy linoleates and possibly other oxygenated fatty acids, which were released from the glycerophospholipids at early times of incubation. There was no effect on the content or molecular species composition of the sphingomyelins or neutral lipids of the lipoproteins. In conclusion, human plasma lipoproteins are the first reported natural biological substrates for human group IIA phospholipase A2. The enhanced hydrolysis of acute phase high density lipoproteins is probably due to its association with serum amyloid A protein, which enhances the activity of the enzyme and may promote its penetration to the lipid monolayer. As sPLA2-induced hydrolysis of the lipoproteins leads to accumulation of lysophosphatidylcholine and potentially toxic oxygenated fatty acids, overexpression of this enzyme may be proatherogenic.
High current plasma based electron source (1990)

This letter analyzes the transport of an electron beam that is produced during the conductive phase operation in the cathode fall of a pseudospark or back lighted thyratron for applications that require a high brightness electron source. The beam is estimated to traverse the device without thermalization if the plasma density is ≤2.5×1015 cm−3. High brightness electron sources are necessary for various new plasma based devices, and these results encourage consideration of this electron beam as a new candidate for applications including microwave generation sources, electron sources for accelerators, and plasma based accelerators which require improved cathodes.
Glycosaminoglycans in emphysematous and fibrotic hamster lungs. (1982)

Amounts and distributions of glycosaminoglycans were measured in lungs obtained from hamsters treated intratracheally 21 to 30 days previously with either saline, purified pancreatic elastase, or bleomycin. Normal hamster lungs contained 150 to 200 micrograms glycosaminoglycans per lung. Lungs made fibrotic by bleomycin contained significantly more glycosaminoglycans per lung than saline-treated control lungs; this increase was equally distributed among all glycosaminoglycan subtypes. Emphysematous lungs also contained more glycosaminoglycans than saline control lungs; this increase was less than that of fibrotic lungs and was limited to the dermatan sulfate subtype. The latter was increased in emphysematous lungs when expressed as a percentage of total glycosaminoglycans. In these hamster models of lung diseases that affect the connective tissue framework of the lungs, changes in lung glycosaminoglycans accompany changes in the other connective tissue components.
Kinetic resolution of fluoroalkyl (E)-vinyl carbinol derivatives by asymmetric epoxidation with titanium-tartrate catalysts. (1987)

Racemic fluoroalkyl (E) -vinyl carbinols (1a-d) were kinetically resolved by Sharpless epoxidation. The optical purity of the resolved alcohols was excellent (98% ee) in mono-and difluoromethyl derivatives (1b and 1c) and moderate (60% ee) in a trifluoromethyl compound (1a).
A Digital Polar CMOS Power Amplifier With a 102-dB Power Dynamic Range Using a Digitally Controlled Bias Generator (2014)

A digitally modulated CMOS power amplifier (DPA) for a polar transmitter with a high dynamic range is presented. To improve local oscillator (LO) leakage, which limits the minimum output power of the DPA, the unit amplifier cell of the DPA employs a balanced mixer-type LO canceller at the power stage and a virtual ground is introduced in the layout of the output-power combining networks. A high dynamic range of the output power is simply achieved by adjusting gate-bias voltage of a cascode transistor in each power amplifier (PA) cell using a digitally controlled bias generator. This architecture allows a few-mA drain current at a low Tx power level without degrading the linearity. An array of unit PA cells is segmented to have a 10-bit amplitude resolution, and the bias generator is designed to have 8-bit control of the average output power. The peak output power is 24.4 dBm with an overall efficiency of 43% at 800 MHz. The total output dynamic range is 102.8 dB. A simple static pre-distortion helps the DPA achieve an average efficiency of 35% with a root mean square error vector magnitude of 3.59% while delivering linear output power of 22 dBm for WCDMA. The range of the digital transmit-power control for the WCDMA signal is 49.7 dB. This chip is fabricated in a 65-nm RF CMOS process.
End-User Programmers and their Communities: An Artifact-based Analysis (2011)

End-user programmers outnumber professionals programmers, write software that matters to an increasingly large number of users, and face software engineering challenges that are similar to their professionals counterparts. Yet, we know little about how these end-user programmers create and share artifacts as part of a community. To gain a better understanding of these issues, we perform an artifact-based community analysis of 32,000 mashups from the Yahoo! Pipes repository. We observed that, like with other online communities, there is great deal of attrition but authors that persevere tend to improve over time, creating pipes that are more configurable, diverse, complex, and popular. We also discovered, however, that end-user programmers employ the repository in different ways than professionals, do not effectively reuse existing programs, and in most cases do not have an awareness of the community. We discuss the implications of these findings.
Biological Oxidations (1952)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
<i>Francisella tularensis</i> tmRNA system mutants are vulnerable to stress, avirulent in mice, and provide effective immune protection (2012)

Through targeted inactivation of the ssrA and smpB genes, we establish that the trans-translation process is necessary for normal growth, adaptation to cellular stress and virulence by the bacterial pathogen Francisella tularensis. The mutant bacteria grow slower, have reduced resistance to heat and cold shocks, and are more sensitive to oxidative stress and sublethal concentrations of antibiotics. Modifications of the tmRNA tag and use of higher-resolution mass spectrometry approaches enabled the identification of a large number of native tmRNA substrates. Of particular significance to understanding the mechanism of trans-translation, we report the discovery of an extended tmRNA tag and extensive ladder-like pattern of endogenous protein-tagging events in F. tularensis that are likely to be a universal feature of tmRNA activity in eubacteria. Furthermore, the structural integrity and the proteolytic function of the tmRNA tag are both crucial for normal growth and virulence of F. tularensis. Significantly, trans-translation mutants of F. tularensis are impaired in replication within macrophages and are avirulent in mouse models of tularemia. By exploiting these attenuated phenotypes, we find that the mutant strains provide effective immune protection in mice against lethal intradermal, intraperitoneal and intranasal challenges with the fully virulent parental strain.
Chemical modification of starch and its application as an adsorbent material (2016)

Starch is a biopolymer of plant origin which is cheap, abundant and has many applications in food and non-food industries.
Bit error rate measurement system for RF integrated circuits (2012)

This paper proposes a bit error rate (BER) measurement system utilizing vector signal analyzer (VSA) instrument built-in analog digital converter (ADC) and ideal digital baseband receiver of VSA software for RF integrated circuits (RFICs) such as RF amplifier, RF mixer and RF receiver. Usually, BER performance is estimated in transceiver with built-in digital baseband circuits. In the past, RF designers could not estimate RFICs effect to BER test without digital baseband circuits and vice versa for digital baseband designers. It is helpful to understand RFICs without digital baseband circuits to BER test can reduce certain risk before integrating RFICs with digital baseband circuits. Therefore, an implementation of output signal to noise ratio (SNR) calibration in a specified bandwidth and measurement method combined VSA instrument, VSA software and Advanced Design System (ADS) is used for BER measurement.
Some Experiments on the Reaction of Titanium with Oxygen and Nitrogen (1948)

In AI-guided PVI of PAF, AI/wall thickness by normalizing myocardial thickness variation along the WACA circle was a strong predictor of gap formation, with a target of 195.6 au/mm appearing suitable for effective ablation.
Handbook of properties of condensed phases of hydrogen and oxygen (1991)

Main symbols liquid hydrogen and its isotopes solid hydrogen and its isotopes liquid oxygen solid oxygen.
Metabolic Syndrome: From Global Epidemiology to Individualized Medicine (2007)

The metabolic syndrome (MetS) encompasses a constellation of metabolic abnormalities that are thought to place patients at higher risk for the development of diabetes and cardiovascular (CV) disease. The underlying pathophysiology is still a point of contention among various professional organizations leading to inconsistencies in the manner in which MetS is defined. Each definition has its advantages and disadvantages. Nonetheless, there is an agreement that insulin resistance and obesity are likely the central contributing factors. Because the prevalence of obesity has been increasing at a frightening rate in the past few decades, MetS represents a major public health problem that should be identified clinically in individual patients. This review describes the changing epidemiology of obesity and of MetS and discusses its importance in CV disease. We outline the existing controversies that surround MetS and discuss the role of lifestyle, pharmacological, surgical, and novel approaches in its management.