gebhart/patrepeval huggingface dataset:
Preparative resolution of <scp>D</scp>,<scp>L</scp>‐threonine catalyzed by immobilized phosphatase (1985)

Hydrolysis of L- and D-O-phosphothreonines catalyzed by four different phosphatases, alkaline phosphatases from calf intestine and E. coli and acid phosphatases from wheat germ and potato, has been kinetically studied. Alkaline phosphatases were found to have comparable reactivities towards the optical isomers. On the other hand, both acid phosphatases displayed a marked stereoselectivity, hydrolyzing the L-ester much faster than its D counterpart. Wheat germ acid phosphatase was the most stereoselective enzyme: V(L)/V(D) = 24 and K(m,L)/K(m,D) = 0.17. This enzyme was immobilized (in k-carrageenan gel, followed by crosslinking with glutaraldehyde) and used for the preparative resolution of D,L-threonine: the latter was first chemically O-phosphorylated and then asymmetrically hydrolyzed by the immobilized phosphatase. As a result, gram quantities of L-threonine of high optical purity and O-phospho-D-threonine were prepared. Immobilized wheat germ phosphatase has been tested for the resolution of other racemic alcohols: serine, 2-amino-1-butanol, 1-amino-2-propanol, 2-octanol, and menthol. In all those cases, the enzyme was either not sufficiently stereoselective or too slow for preparative resolutions.
Validation of Porcine Knee as a Sex-specific Model to Study Human Anterior Cruciate Ligament Disorders (2014)

The findings highlight the use of the porcine large animal model to study the role of sex on ACL injuries and surgical outcome. This validated preclinical model may facilitate the development of novel, sex-specific interventions to prevent and treat ACL injuries for male and female patients.
Focus: The interface between data collection and data processing in cryo-EM (2017)

We present a new software package called Focus that interfaces cryo-transmission electron microscopy (cryo-EM) data collection with computer image processing. Focus creates a user-friendly environment to import and manage data recorded by direct electron detectors and perform elemental image processing tasks in a high-throughput manner while new data is being acquired at the microscope. It provides the functionality required to remotely monitor the progress of data collection and data processing, which is essential now that automation in cryo-EM allows a steady flow of images of single particles, two-dimensional crystals, or electron tomography data to be recorded in overnight sessions. The rapid detection of any errors that may occur greatly increases the productivity of recording sessions at the electron microscope.
Toxicity of antiglaucoma drugs with and without benzalkonium chloride to cultured human corneal endothelial cells (2010)

Antiglaucoma eye drops produced HCEC toxicity that appeared to depend on the presence of BAK. Because dilution of the antiglaucoma solutions resulted in markedly lower HCEC toxicity, HCEC damage due to antiglaucoma medication may occur only in rare cases. The CVS was useful for comparison of the toxicity of the drugs.
Quibbs, a Code Generator for Quantum Gibbs Sampling (2010)

This paper introduces Quibbs v1.3, a Java application available for free. (Source code included in the distribution.) Quibbs is a "code generator" for quantum Gibbs sampling: after the user inputs some files that specify a classical Bayesian network, Quibbs outputs a quantum circuit for performing Gibbs sampling of that Bayesian network on a quantum computer. Quibbs implements an algorithm described in earlier papers, that combines various apple pie techniques such as: an adaptive fixed-point version of Grover's algorithm, Szegedy operators, quantum phase estimation and quantum multiplexors.
Revision total knee arthroplasty: planning, management, controversies, and surgical approaches. (2001)

Revision total knee arthroplasty can be a technically challenging procedure fraught with potential complications. In many cases, obtaining adequate exposure is difficult, and failure to do so can directly cause technical errors and complications. Patient-specific systemic comorbidities and anatomic details can further complicate the procedure. Careful preoperative evaluation can help to facilitate optimal results. Furthermore, specific surgical techniques help to improve the surgical exposure and can minimize complications such as wound healing problems, component malposition, and extensor mechanism disruption. All surgeons undertaking these procedures require a thorough understanding of these principles.
Optimized very fast decision tree with balanced classification accuracy and compact tree size (2011)

Very Fast Decision Tree (VFDT) in data stream mining has been widely studied for more than a decade. VFDT in essence can mine over a portion of an unbounded data stream at a time, and the structure of the decision tree gets updated whenever new data feed in; hence it can predict better upon the input of fresh data. Inherent from traditional decision trees that use information gains for tree induction, VFDT may suffer the same over-fitting problem where noise in the training data leads to excessive tree branches therefore decline in prediction accuracy. This problem is aggravated in stream mining because limited run-time memory (for storing the whole decision tree) and reasonable accuracy are often the criteria for implementing VFDT. Post-pruning that was a popular technique used in traditional decision tree to keep the tree size in check, however may not be applicable for VFDT in situ. In this paper a new model that extends from VFDT called Optimized VFDT is proposed, for controlling the tree size while sustaining good prediction accuracy. This is enabled by using an adaptive threshold tie and incremental pruning in tree induction. Experimental results show that an optimal ratio of tree size and accuracy can be achieved by OVFDT.
Stress Hormone–Mediated Invasion of Ovarian Cancer Cells (2006)

These findings provide direct experimental evidence that stress hormones can enhance the invasive potential of ovarian cancer cells. These effects are most likely mediated by stimulation of MMPs.
All Inorganic Semiconductor Nanowire Mesh for Direct Solar Water Splitting (2014)

The generation of chemical fuels via direct solar-to-fuel conversion from a fully integrated artificial photosynthetic system is an attractive approach for clean and sustainable energy, but so far there has yet to be a system that would have the acceptable efficiency, durability and can be manufactured at a reasonable cost. Here, we show that a semiconductor mesh made from all inorganic nanowires can achieve unassisted solar-driven, overall water-splitting without using any electron mediators. Free-standing nanowire mesh networks could be made in large scales using solution synthesis and vacuum filtration, making this approach attractive for low cost implementation.
An interactive solution to adaptive phase jitter cancellation (2002)

The paper describes a new technique for adaptive cancellation of phase jitter based on IIR filtering. If all the possible sources of phase jitter are known a priori for a given system, then their effect can be interactively filtered out by the proposed algorithm. In addition to offering a cost effective solution for combating the effects of severe phase jitter, this algorithm yields a fast response time to interactive sources of phase jitter. The proposed algorithm will not face any noise/bandwidth conflicts and, hence, it will make no sacrifice in performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers (1998)

R093877 is well tolerated by healthy subjects and has a marked and consistent effect on stool frequency and consistency, and upper gut and colonic transit. It does not affect visceral sensitivity or sphincter function. It holds promise for patients with large bowel symptoms or slow gut transit.
An Analytic Wavelet Transform With a Flexible Time-Frequency Covering (2012)

We develop a rational-dilation wavelet transform for which the dilation factor, the Q-factor and the redundancy can be easily specified. The introduced transform contains Hilbert transform pairs of atoms, therefore it is also suitable for oscillatory signal processing. The transform may be modified to obtain a tight chirplet frame for discrete-time signals. A fast implementation, that makes use of an equivalent filter bank, makes the transform suitable for long signals. Examples on natural signals are provided to demonstrate the utility of the transform.
Automatic DNA Diagnosis for 1D Gel Electrophoresis Images using Bio-image Processing Technique (2015)

This work presents an automated genotyping tool from DNA gel electrophoresis images, called GELect, which was written in Java and made available through the imageJ framework. With a novel automated image processing workflow, the tool can accurately segment lanes from a gel matrix, intelligently extract distorted and even doublet bands that are difficult to identify by existing image processing tools. Consequently, genotyping from DNA gel electrophoresis can be performed automatically allowing users to efficiently conduct large scale DNA fingerprinting via DNA gel electrophoresis. The software is freely available from http://www.biotec.or.th/gi/tools/gelect.
A low-power, lightweight unit to provide ubiquitous information access application and network support for InfoPad (1996)

Some of the most important trends in computer systems are the emerging use of multimedia Internet services, the popularity of portable computing, and the development of wireless data communications. The primary goal of the InfoPad project is to combine these trends to create a system that provides ubiquitous information access. The system is built around a low-power, lightweight wireless multimedia terminal that operates in indoor environments and supports a high density of users. The InfoPad system uses a number of innovative techniques to provide the high-bandwidth connectivity, portability, and user interface needed for this environment. The article describes the design, implementation, and evaluation of the software network and application services that support the InfoPad terminal. Special applications, type servers, and recognizers are developed for the InfoPad system. This software is designed to take advantage of the multimedia capabilities of the portable terminal and the additional computational resources available on the servers. The InfoNet system provides low-latency, high bandwidth connectivity between the computation and the portable terminal. It also provides the routing and handoff support that allows users to roam freely. The performance measurements of the system show that this design is a viable alternative, especially in the indoor environment.
High Read Stability and Low Leakage Cache Memory Cell (2007)

Data in conventional six transistor (6T) static random access memory (SRAM) cells are vulnerable to noise due to the direct access to the data storage nodes through the bit lines during a read operation. A new nine transistor (9T) SRAM cell is proposed in this paper for simultaneously enhancing read stability and reducing leakage power consumption. The proposed 9T SRAM cell isolates the data from the bit lines during a read operation. The read static-noise-margin (SNM) of the proposed circuit is enhanced by 2times as compared to a standard 6T SRAM cell in a 65 nm CMOS technology. Furthermore, leakage power consumption of the new 9T SRAM cell is reduced by 22.9% as compared to the 6T SRAM cell. The read stability enhancement and leakage power reduction provided by the new circuit technique are also verified under process parameter variations.
A single-shot shimming sequence using low-power RF noise pulses for localized in vivo NMR spectroscopy (1992)

The authors describe a technique for spatially localized nuclear magnetic resonance (NMR) in vivo clinical spectroscopic examinations. It concerns the optimization of the magnetic field homogeneity ('shimming'). A localizing shimming pulse sequence designed specifically for use with the 'ISIS' spectroscopic localization pulse sequence is presented. The shimming sequence employs reduced bandwidth RF noise pulses to randomize unwanted signals from outer regions of the sample. By reducing the bandwidth of the noise pulses substantial RF power reduction is achieved (e.g. a factor of five), without impairment of localization performance. Identical gradient amplitudes and timings are used for both the shimming and data acquisition sequences, therefore the effects of induced eddy currents can be evaluated and minimized during the shimming process. Experimental data demonstrating the use of the method in vivo are presented.
A Biopharmaceutical Industry Perspective on the Control of Visible Particles in Biotechnology-Derived Injectable Drug Products (2016)

In the 2011 monoclonal antibody monograph revision, European Pharmacopoeia experts acknowledged that protein products may also contain proteinaceous particles at release or that protein particles may form during storage. Indeed, industry experience has demonstrated that therapeutic proteins such as monoclonal antibodies can exhibit a propensity for self-association leading to the formation of aggregates that range in size from nanometres (oligomers) to microns (subvisible and visible particles). As a result, the requirement for drug product appearance for monoclonal antibodies was changed from "without visible particles" to "without visible particles unless otherwise authorised or justified". In our view, "practically free from particles" should be considered a suitable acceptance criterion for injectable biotechnology and small-molecule products, as long as appropriately defined. Furthermore, we argue that visual inspection is a suitable quality control release test and that "practically free from particles" is a suitable specification when adequately described.
Syntheses, Structural Characterization, and Luminescence Behavior of Face-to-Face Diplatinum(II) Alkynyl Complexes (2002)

A series of luminescent face-to-face dinuclear platinum(II) alkynyl complexes, [Pt2(μ-dppm)2(C⋮CR)4] (R = C6H4-Cl-p, C6H4-NO2-p, SiMe3), and a mixed-metal platinum(II)−silver(I) complex, [Pt2(μ-dppm)2(C⋮CPh)4·{Ag(MeCN)}2](BF4)2, were synthesized and characterized by both spectroscopy and X-ray crystallography. Their luminescence behavior were studied and the nature of the emission origin was elucidated by comparison studies involving the perturbation of Pt···Pt distances as well as the π-accepting ability of the alkynyl group through a systematic variation of the nature of the alkynyl moieties and metal ion encapsulation.
Rapid isolation and detection of drugs in meconium of infants of drug-dependent mothers. (1988)

Journal Article Rapid isolation and detection of drugs in meconium of infants of drug-dependent mothers. Get access E M Ostrea, Jr, E M Ostrea, Jr Dept. of Pediatrics, Hutzel Hospital, Wayne State University, Detroit, MI 48201 Search for other works by this author on: Oxford Academic Google Scholar P M Parks, P M Parks Dept. of Pediatrics, Hutzel Hospital, Wayne State University, Detroit, MI 48201 Search for other works by this author on: Oxford Academic Google Scholar M J Brady M J Brady Dept. of Pediatrics, Hutzel Hospital, Wayne State University, Detroit, MI 48201 Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 34, Issue 11, 1 November 1988, Pages 2372–2373, https://doi.org/10.1093/clinchem/34.11.2372a Published: 01 November 1988
Conceptual linking (2001)

Article Conceptual linking: ontology-based open hypermedia Share on Authors: Leslie Carr Intelligence, Agents, Multimedia, Department of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UK Intelligence, Agents, Multimedia, Department of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UKView Profile , Wendy Hall Intelligence, Agents, Multimedia, Department of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UK Intelligence, Agents, Multimedia, Department of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UKView Profile , Sean Bechhofer Information Management Group, Department of Computer Science, University of Manchester, Oxford Road, Manchester M13 9PL, UK Information Management Group, Department of Computer Science, University of Manchester, Oxford Road, Manchester M13 9PL, UKView Profile , Carole Goble Information Management Group, Department of Computer Science, University of Manchester, Oxford Road, Manchester M13 9PL, UK Information Management Group, Department of Computer Science, University of Manchester, Oxford Road, Manchester M13 9PL, UKView Profile Authors Info & Claims WWW '01: Proceedings of the 10th international conference on World Wide WebMay 2001 Pages 334–342https://doi.org/10.1145/371920.372084Online:01 April 2001Publication History 93citation1,575DownloadsMetricsTotal Citations93Total Downloads1,575Last 12 Months12Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Stand der Technik (1980)

Der Eisen-Dampf-Prozeß ist eines der ältesten Verfahren zur Herstellung von Wasserstoff und war bereits im 18. Jahrhundert bekannt. Das Verfahren beruht darauf, daß Eisen im rotglühenden Zustand den Sauerstoff des Wasserdampfes bindet, so daß Wasserstoff und Eisenoxide entstehen. Vorzugsweise werden sich dabei Wüstit (FeO) und Magnetit (Pe3O4) bilden, da Hämatit (Fe2O3) schon durch Spuren von Wasserstoff wieder reduziert wird.
Mineralocorticoid Receptor Activation Promotes Vascular Cell Calcification (2007)

Aldosterone activation of MR promotes osteoblastic differentiation and mineralization of VSMCs independent of BMP2 signaling. These data provide a mechanistic link between hormone-mediated VSMC MR activation and vascular calcification, two processes associated with increased risk of cardiovascular ischemic events in humans.
Mapping Protein−Protein Interactions within a Stable Complex of DNA Primase and DnaB Helicase from <i>Bacillus stearothermophilus</i> (1999)

For the first time, we demonstrate directly a stable complex between a bacterial DnaG (primase) and DnaB (helicase). Utilizing fragments of both proteins, we are able to dissect interactions within this complex and provide direct evidence that it is the C-terminal domain of primase that interacts with DnaB. Furthermore, this C-terminal domain is sufficient to induce maximal stimulation of the helicase and ATPase activities of DnaB. However, the region of DnaB that interacts with the C-terminal domain of primase appears to comprise a surface on DnaB that includes regions from both of the previously identified N- and C-terminal domains. Using a combination of biochemical and physical techniques, we show that the helicase-primase complex comprises one DnaB hexamer and either two or three molecules of DnaG. Our results show that in Bacillus stearothermophilus the helicase-primase interaction at the replication fork may not be transient, as was shown to be the case in Escherichia coli. Instead, primase appears to interact with the helicase forming a tighter complex with enhanced ATPase and helicase activities.
"Learning to Govern": The Texas Experience (2006)

n January 14, 2003, the first Republican majority in 130 years took control of the Texas House of Representa-tives. How did the Texas House change as the Republi-can Party assumed the role of the majority party and the Democ-rats the role of the minority party? For the previous twenty years the Texas House operated as a partially bipartisan rather than a partisan legislature, unlike the modern U.S. House of Represen-tatives. Did the Texas House continue the tradition under new management, or did it become increasingly partisan? Why? In brief, what were the significant changes and continuities in the
Bicarbonate and ammonia changes in brain during spreading depression (1987)

An alkaline, followed by an acid-going transient, characterizes acid-base changes in the interstitial space during spreading depression in a variety of brain structures. In rat, such changes are associated with a significant rise in brain lactate content. How brain proton buffers behave during spreading depression is unknown. Techniques to significantly improve the response time of gas permeable membrane semimicroelectrodes for carbon dioxide and ammonia are reported. Measurements with such electrodes, when coupled to measurements of hydrogen ion concentration (from microelectrodes), permit rapid changes to be determined in bicarbonate concentration or ammonia and ammonium ion concentration, respectively. Bicarbonate concentration fell from 30 +/- 1 (n = 16) to 14 +/- 1 mM (n = 16) during spreading depression. On the other hand, ammonia concentration rose from 2.3 +/- 0.1 to 4.4 +/- 0.3 microM (n = 17) while ammonium ion concentration rose from 116 +/- 11 (n = 17) to 382 +/- 30 microM (n = 17) during spreading depression. Bicarbonate changes probably reflect titration of brain bicarbonate stores by accumulated lactic acid. Similar physicochemical changes do not explain the rise in ammonia and ammonium ion concentrations. Instead, elevation of the latter can only result from an increase in ammonia content of the interstitial space.
Signal loss in the motor cortex on magnetic resonance images in amyotrophic lateral sclerosis (1993)

Three of 7 patients with amyotrophic lateral sclerosis had bilateral signal loss confined to the motor cortex on T2-weighted magnetic resonance images. None of the control subjects had this abnormality. Although not present in every patient, this finding might reflect the primary pathological process of the motor cortex in amyotrophic lateral sclerosis.
Flexible Ultrafast Aqueous Rechargeable Ni//Bi Battery Based on Highly Durable Single‐Crystalline Bismuth Nanostructured Anode (2016)

A new type of ultrafast Ni//Bi battery with high flexibility and impressive electrochemical performance is demonstrated for the first time based on an as-prepared Bi electrode as the anode and a NiCo<sub>2</sub> O<sub>4</sub> nanowire electrode as the cathode. The NiCo<sub>2</sub> O<sub>4</sub> //Bi battery is able to deliver a remarkable energy density of 85.8 W h kg<sup>-1</sup> at a power density of 1.02 kW kg<sup>-1</sup> , and still retains 55.4 W h kg<sup>-1</sup> when the power density is increased to 21.2 kW kg<sup>-1</sup> .
Thermal imaging for law enforcement and security: post 9-11 (2003)

Video systems are the backbone of most modern security systems. They help security personnel detect and recognize people who don’t belong in specific areas and who warrant suspicion. Low cost, low power uncooled thermal imaging sensors have completely changed the way the world views the video systems used in security, surveillance and law enforcement. Thermal Imaging (TI) is the only completely passive, all-weather, 24-hr surveillance tool that allows security personnel to take back the night, something they couldn’t do with inferior techniques of surveillance. This paper addresses advances in IR senosrs for law enforcement and security. It also addresses the bigger picture of using these sensors in the ever evolving and improving law enforcement and security surveillance system.