gebhart/patrepeval huggingface dataset:
The Clinical Interview and the Doctor–Patient Relationship in Telemedicine (2005)

The doctor-patient relationship is one of the most complex interpersonal relationships, in that it involves individuals who are not on the same level, it has not been sought by both individuals, it is emotionally loaded and it requires close mutual co-operation towards a shared goal. A well-managed clinical interview lays the grounds for a good doctor-patient relationship which in turn leads to further advantages. In a classical ambulatory setting the doctor-patient relationship should take into account a number of context variables: physical environment, doctor's clothing and instrumental vs. affective behavior. The classical medical consultation takes place with the doctor and patient facing each other in the same room. Human contact, interaction and communication condition the course and treatment of the illness. This classical setting has been radically changed with the advent of videoconferencing. Video-communication reduces personal contact with the general doctor or specialist. Medical philosophy and the social sciences have often discussed the risk of alienating or "objectifying" the patient. The setting of a videoconferencing interview is completely different as interaction is not direct but occurs via a technological system that enables an unusual form of visual and auditory interaction that may be more or less realistic depending on the technology employed. The growing use of telemedicine and videoconferencing has led to new reflections on the doctor-patient relationship in non-conventional settings and warrants in-depth studies on the dynamics of this form of consultation so as to increase the patients' level of satisfaction in telemedicine. The next step will be to verify experimentally and with adequate tools what the demands of patients are in a videoconferencing setting.
Toward Functionally Graded Cellular Microstructures (2009)

The design of multifunctional materials offers great potential for numerous applications in areas ranging from biomaterial science to structural engineering. Functionally graded microstructures (e.g., polymeric foams) are those whose porosity (i.e., ratio of the void to the solid volume of a material) is engineered to meet specific requirements such as a superior mechanical, thermal, and acoustic behavior. The controlled distribution of pores within the matrix, as well as their size, wall thickness, and interconnectivity are directly linked to the porous materials properties. There are emerging design and analysis methods of cellular materials but their physical use is restricted by current manufacturing technologies. Although a huge variety of foams can be manufactured with homogeneous porosity, for heterogeneous foams there are no generic processes for controlling the distribution of porosity throughout the resulting matrix. This paper describes work to develop an innovative and flexible process for manufacturing engineered cellular structures. Ultrasound was applied during specific foaming stages of a polymeric (polyurethane) melt, and this affected both the cellular architecture and distribution of the pore size, resulting in a controlled distribution that can be designed for specific purposes, once the polymeric foam solidified. The experimental results demonstrate that porosity (i.e., volume fraction) varies in direct proportion to the acoustic pressure magnitude of the ultrasonic signal.
High pressure die casting of Fe-based metallic glass (2016)

Soft ferromagnetic Fe-based bulk metallic glass key-shaped specimens with a maximum and minimum width of 25.4 and 5 mm, respectively, were successfully produced using a high pressure die casting (HPDC) method, The influence of die material, alloy temperature and flow rate on the microstructure, thermal stability and soft ferromagnetic properties has been studied. The results suggest that a steel die in which the molten metal flows at low rate and high temperature can be used to produce completely glassy samples. This can be attributed to the laminar filling of the mold and to a lower heat transfer coefficient, which avoids the skin effect in the steel mold. In addition, magnetic measurements reveal that the amorphous structure of the material is maintained throughout the key-shaped samples. Although it is difficult to control the flow and cooling rate of the molten metal in the corners of the key due to different cross sections, this can be overcome by proper tool geometry. The present results confirm that HPDC is a suitable method for the casting of Fe-based bulk glassy alloys even with complex geometries for a broad range of applications.
Using Continuum Mechanics Operators for detection and Quantification of Evolving Processes in 3D Medical Images (1999)

International audience
Assessment of Organ Dosimetry for Planning Repeat Treatments of High-Dose 131I-MIBG Therapy (2017)

For repeat I-MIBG treatment planning, both I-MIBG and I-MIBG imaging yielded variable organ doses. However, I-MIBG-based dosimetry yielded a more conservative estimate of maximum allowable activity and would be suitable for planning and limiting organ toxicity with repeat high-dose therapies.
Betaine–Carbene Interconversions. From N-Ylides to Zwitterionic N-Heterocyclic Carbene–Borane Adducts (2013)

In the presence of NBS 3-methylindole reacted with various imidazoles to give the (indol-2-yl)imidazolium salts 21a-f, which were converted in aqueous solution into the 2-(imidazolium-3-yl)-3-methylindolates 22a-f by base. These conjugated ylides--which represent a subclass of mesomeric betaines--are the exclusively detectable form in the NMR spectra taken in DMSO-d(6). A DFT calculation revealed that the betaine 22a is -9.3 kJ/mol more stable than the tautomeric N-heterocyclic carbene 23a and that the energy for the betaine-carbene interconversion is ΔG(‡) = 66.4 kJ/mol. The N-heterocyclic carbenes (3-methyl-indol-2-yl)imidazol-2-ylidenes, however, can be trapped by sulfur, triethylborane, and triphenylborane. Whereas the first trapping reaction yielded the expected imidazolethiones, the borates gave the first representatives of new zwitterionic borane adducts, imidazo[2',1':3,4][1,4,2]diazaborolo[1,5-a]indolium-11-ides 26a-h. We performed DFT calculations on the structures of mesomeric betaine 22a, the carbene 23a, and the mechanisms of the borane adduct formation to 26a-h, NMR spectroscopic investigations including (15)N, (7)Li, and (11)B NMR spectroscopy, and an X-ray single-crystal analysis of one of the borane adducts.
Programming the World Wide Web (2001)

Programming the World Wide Web is intended for undergraduate students who have completed a course in object-oriented programming. It also serves as an up-to-date reference for Web programming professionals. Programming the World Wide Web provides a comprehensive introduction to the tools and skills required for both client- and server-side programming, teaching students how to develop platform-independent sites using the most current Web development technology. Essential programming exercises are presented using a manageable progression: students begin with a foundational Web site and employ new languages and technologies to add features as they are discussed in the course. Readers with previous experience programming with an object-oriented language are guided through concepts relating to client-side and server-side programming. All of the markup documents in the book are validated using the W3C validation program. Teaching and Learning Experience This program presents a better teaching and learning experiencefor you and your students. It will help: Teach Students how to Develop Platform-independent Sites:Students will benefit from a comprehensive introduction to the tools and skills required for both client- and server-side programming. Present Essential Programming Exercises in a Logical Progression:Students begin with a foundational Web site and employ new languages and technologies to add features as they are discussed in the course.
Isolation and characterization of acidocin A and cloning of the bacteriocin gene from Lactobacillus acidophilus (1995)

Acidocin A, a bacteriocin produced by Lactobacillus acidophilus TK9201, is active against closely related lactic acid bacteria and food-borne pathogens including Listeria monocytogenes. The bacteriocin was purified to homogeneity by ammonium sulfate precipitation and sequential ion-exchange and reversed-phase chromatographies. The molecular mass was determined by high-performance liquid chromatography gel filtration to be 6,500 Da. The sequence of the first 16 amino acids of the N terminus was determined, and oligonucleotide probes based on this sequence were constructed to detect the acidocin A structural gene acdA. The probes hybridized to the 4.5-kb EcoRI fragment of a 45-kb plasmid, pLA9201, present in L. acidophilus TK9201, and the hybridizing region was further localized to the 0.9-kb KpnI-XbaI fragment. Analysis of the nucleotide sequence of this fragment revealed that acidocin A was synthesized as an 81-amino-acid precursor including a 23-amino-acid N-terminal extension. An additional open reading frame (ORF2) encoding a 55-amino-acid polypeptide was found downstream of and in the same operon as acdA. Transformants containing this ORF2 became resistant to acidocin A, suggesting that ORF2 encodes an immunity function for acidocin A. The 7.2-kb SacI-XbaI fragment containing the upstream region of acdA of pLA9201 was necessary for acidocin A expression in the acidocin A-deficient mutant, L. acidophilus TK9201-1, and other Lactobacillus strains.
Understanding quantified-selfers' practices in collecting and exploring personal data (2014)

Researchers have studied how people use self-tracking technologies and discovered a long list of barriers including lack of time and motivation as well as difficulty in data integration and interpretation. Despite the barriers, an increasing number of Quantified-Selfers diligently track many kinds of data about themselves, and some of them share their best practices and mistakes through Meetup talks, blogging, and conferences. In this work, we aim to gain insights from these "extreme users," who have used existing technologies and built their own workarounds to overcome different barriers. We conducted a qualitative and quantitative analysis of 52 video recordings of Quantified Self Meetup talks to understand what they did, how they did it, and what they learned. We highlight several common pitfalls to self-tracking, including tracking too many things, not tracking triggers and context, and insufficient scientific rigor. We identify future research efforts that could help make progress toward addressing these pitfalls. We also discuss how our findings can have broad implications in designing and developing self-tracking technologies.
<i>N</i>-Methylsansalvamide A Peptide Analogues. Potent New Antitumor Agents (2005)

Sansalvamide A, a cyclic depsipeptide isolated from a marine fungus of the genus Fusarium, is composed of four hydrophobic amino acids (Phe, two Leu, Val) and one hydroxy acid ((S)-2-hydroxy-4-methylpentanoic acid; O-Leu) with five stereogenic centers all having S-stereochemistry. We have recently synthesized the corresponding cyclic peptide (Gu, W.; Liu, S.; Silverman, R. B. Organic Lett. 2002, 4, 4171−4174) and found that it too has antitumor activity. N-Methylation can enhance potency and selectivity for peptides. Consequently, here we synthesize 12 different N-methylated sansalvamide A peptide analogues and show that for several different tumor cell lines three of these analogues are more potent than the natural product; in pancreatic cells, sansalvamide A shows little activity, but the N-methylsansalvamide peptides are potent cytotoxic agents.
Robot-assisted catheter insertion using hybrid impedance control (2006)

Angioplasty is a minimally invasive procedure wherein a catheter (a thermoplastic hollow wire) is inserted into the femoral artery and guided till it reaches a blockage in the blood vessel. There could be some potential complications arising from the conventional way of performing angioplasty, e.g., damage to the blood vessel due to excessive force of insertion and exposure of clinicians to harmful radiations and/or high levels of noise from an MRI machine. In this paper, we investigate the use of a robot manipulator (Mitsubishi PA 10-7C) to aid in the insertion of a catheter into a blood vessel. The robot controls the insertion force while the surgeon can remotely operate the robot from a safe and comfortable environment. The paper describes a hybrid impedance control scheme implemented on the Mitsubishi robot to perform simultaneous force/position control. The robot is used in experiments to insert a catheter into a test-bed by controlling the force of insertion and preventing the catheter from buckling or "bunching up". Experimental results for the insertion algorithms are shown
Correlation of Kyo-kyo-kuman and Somatization Symptoms: Clinical Study using Keio's Kyo-kyo-kuman scale (K-scale) and Screener for Somatoform Disorders (SSD) (2005)

「胸脇苦満」は, 現代医学的には分析がされていない。著者は, これまでの研究結果より, 胸脇苦満は身体化症状の重症度を反映するという仮説を立てた。この仮説を検討するため, 胸脇苦満と身体化症状との相関を, 慶大式胸脇苦満評価尺度 (K尺度) と Screener for Somatoform Disorders (SSD) を用いて検討した。150例 (男性38例, 女性112例, 平均年齢40.69±17.56歳) を対象として, 胸脇苦満の程度と身体化症状数の評価を行った。右側のK尺度得点 (胸脇苦満の程度) と, 現在ある身体化症状の数 (R=0.440, p<0.0001), 過去1年間にあった身体化症状の数 (R=0.476, p<0.0001) との間, 左側のK尺度得点と, 3ヵ月以上続いた身体化症状の数 (R=0.450, p<0.0001), 現在ある身体化症状の数 (R=0.597, p<0.0001), 過去1年間にあった身体化症状の数 (R=0.586, p<0.0001) との間に, それぞれ有意な相関を認めた。以上の結果より, 胸脇苦満を呈する患者ほど多くの身体化症状を訴える傾向にあった。胸脇苦満と身体化症状の関連が示唆された。
Near-infrared free carrier absorption in heavily doped silicon (2014)

Free carrier absorption in heavily doped silicon can have a significant impact on devices operating in the infrared. In the near infrared, the free carrier absorption process can compete with band to band absorption processes, thereby reducing the number of available photons to optoelectronic devices such as solar cells. In this work, we fabricate 18 heavily doped regions by phosphorus and boron diffusion into planar polished silicon wafers; the simple sample structure facilitates accurate and precise measurement of the free carrier absorptance. We measure and model reflectance and transmittance dispersion to arrive at a parameterisation for the free carrier absorption coefficient that applies in the wavelength range between 1000 and 1500 nm, and the range of dopant densities between ∼1018 and 3 × 1020 cm−3. Our measurements indicate that previously published parameterisations underestimate the free carrier absorptance in phosphorus diffusions. On the other hand, published parameterisations are generally consistent with our measurements and model for boron diffusions. Our new model is the first to be assigned uncertainty and is well-suited to routine device analysis.
A Wide-Range Thermistor Radiometer for the Measurement of Skin Temperature and Environmental Radiant Temperature (1954)

The thermistor radiometer consists of a Wheatstone bridge formed of four thermistors, two of which are exposed to incident radiation and two of which are hidden from it and act as thermal compensators. The output from the bridge is suitably amplified and fed into a microammeter on which deflections are read in microamperes and related to radiant temperatures by means of calibration charts. Calibrations are made against standard blackbody radiators and at present have been carried out for use of the instrument in ambient temperatures between −50°C and +30°C for measuring radiant temperatures between −185°C and +60°C. The instrument has been used successfully in (1) the measurement of skin temperatures indoors at normal room temperature and outdoors in ambient temperatures as low as −45°C; and (2) the measurement of the radiant temperature of the sky and ground in temperate and in arctic climates.
SRN1 studies. 26. SRN1-based methodology for synthesis of naphthylquinolines and naphthylisoquinolines (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSRN1 studies. 26. SRN1-based methodology for synthesis of naphthylquinolines and naphthylisoquinolinesRene Beugelmans and Michele Bois-ChoussyCite this: J. Org. Chem. 1991, 56, 7, 2518–2522Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/jo00007a046https://doi.org/10.1021/jo00007a046research-articleACS PublicationsRequest reuse permissionsArticle Views256Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group. (1998)

This large, controlled randomized clinical trial confirms that 5 weekly IA injections of HA (Hyalgan) in patients with OA of the knee are generally well tolerated, provide sustained relief of pain and improved patient function, and were at least as effective with fewer adverse reactions as continuous treatment with naproxen for 26 weeks.
Radiation dosimetry using nuclear magnetic resonance: an introductory review (1990)

Almost every known effect of ionizing radiation on matter, whether it be physical, chemical or biological, has been suggested as a basis for dosimetry, especially if the matter is (or can be made) dosimetrically tissue-equivalent. The latest candidate for attention is the magnetic resonance effect, the dosimetric application of which has been pioneered by British, American and Swedish workers (Gore et al. 1984, Appleby et al. 1987, Olsson et al. 1989). The method has a number of interesting features, though it may be unfamiliar to many regular practitioners of clinical dosimetry. The author gives an introductory review intended to place the new method in the broad context of radiotherapy dosimetry.
Identification of Endoglycan, a Member of the CD34/Podocalyxin Family of Sialomucins (2000)

CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors. These glycoproteins have been proposed to be involved in processes as diverse as glomerular filtration, inhibition of stem cell differentiation, and leukocyte-endothelial adhesion. Using homologies present in the cytoplasmic tails of these proteins, we have identified a novel member of this family, which we designate endoglycan. This protein shares a similar overall domain structure with the other family members including a sialomucin domain, but also possesses an extremely acidic amino-terminal region. In addition, endoglycan contains several potential glycosaminoglycan attachment sites and is modified with chondroitin sulfate. Endoglycan mRNA and protein were detected in both endothelial cells and CD34(+) bone marrow cells. Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors. While the members of this family may perform overlapping functions at these sites, the unique structural features of endoglycan suggest distinct functions for this molecule.
Improvement of electrical performance of anisotropically conductive adhesives (2005)

To improve the electrical properties of the anisotropically conductive adhesive (ACA) joints with the potential for fine pitch interconnect, self-assembled monolayer (SAM) compounds are introduced to treat nano silver (Ag) fillers. Thermogravimetric analyzer (TGA), differential scanning calorimeter (DSC), contact angle and photoacoustic Fourier transfer infrared (FTIR) results indicated the SAMs were well coated on the nano Ag particles. Furthermore, these SAM-treated ACAs were thermally stable at processing temperatures of the ACA samples. By introducing the novel SAM materials into the interfaces between nano metal fillers and the substrate bond pads, the conductivity and current carrying capability of ACAs were improved significantly due to the stronger bonding between nano fillers and SAM and consequently the improved interface properties of the high performance ACA. The improved electrical performance of nano Ag filled ACAs was accompanied with the higher thermal conductivity as well.
Butitaxel Analogues:  Synthesis and Structure−Activity Relationships (1997)

N-Acyl analogues 8, 9, and 12-26 of butitaxel (3) were prepared in one or two steps from amines 5 and 6 through Schotten-Baumann acylation. Seventeen novel analogues, consisting of aliphatic carbamates, alicyclic amides, and heteroaromatic amides, were synthesized. They were evaluated for their in vitro ability to stimulate the formation of microtubules, their cytotoxicity toward B16 melanoma cells, and their solubility in water. The most potent analogue found in this study was N-debenzoyl-N-(2-thenoyl)butitaxel (20), possessing ca. 2-fold better tubulin assembly properties and cytotoxic activity against B16 melanoma cells than paclitaxel. Compound 20 was ca. 25 times more water soluble than paclitaxel.
G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes (1995)

Receptors for chemoattractants that direct the migration of phagocytic leukocytes to sites of injury/infection also modulate many other leukocyte functions that are critical to the inflammatory response. These chemoattractant receptors, members of the G protein-coupled heptahelical receptor family, have been classically linked to cell activation via phospholipase C, calcium, and protein kinase C. We show here that activation of the N-formyl peptide chemoattractant receptor stimulates an additional protein kinase C-independent pathway through the Src-related tyrosine kinase, Lyn, in human neutrophils. We demonstrate that activation of Lyn is associated with binding to the Shc adapter protein, which becomes phosphorylated on tyrosine residues. This interaction appears to be mediated via the Shc SH2 domain. Complexes of phosphorylated Lyn and Shc with phosphatidylinositol 3-kinase are rapidly formed in stimulated neutrophils, correlating with phosphatidylinositol 3,4,5-trisphosphate [corrected] formation and cell activation. This signaling pathway involving a Src-related kinase and the Shc adapter protein provides a potential mechanism linking chemoattractant receptors to downstream events involving Rac activation and NADPH oxidase. Regulation of Shc by G protein-coupled receptors may also allow these receptors to modulate the activity of the Ras/mitogen-activated protein kinase cascade.