gebhart/patrepeval huggingface dataset:
Isoflurane Preserves Spatial Working Memory in Adult Mice After Moderate Hypoxia (2006)

Perioperative hypoxia may contribute to postoperative cognitive impairment. It is unknown, however, whether anesthetics exacerbate or protect against hypoxia-related central nervous system impairment. We sought to determine whether hypoxia alone or in combination with isoflurane disrupts working memory in mice. To this extent, we assigned adult mice to one of four treatments for 1 h: oxygen 21%, oxygen 21% + isoflurane 1.2%, oxygen 8%, or oxygen 8% + isoflurane 1.2%. Mice breathed spontaneously throughout the experiment. Body temperature was maintained at 37 degrees C + 0.5 degrees C. Mice were allowed to recover for 24 h to avoid the confounding influence of residual anesthetics on neurobehavioral performance. Working memory was assessed by use of a Y maze modified for mice. For the training trial, entry to one arm was blocked and mice were permitted to run between the two open arms for 15 min and inspect the objects outside. For the test trial, carried out 1 h later, all arms were open. Time spent in each arm was automatically recorded by a camera and associated software. Mice were tested 1, 4, and 7 days after anesthesia. A different arm was used as the novel arm for each test. Performance was analyzed with repeated-measurements analysis of variance, followed by analysis of simple main effects and by post hoc comparison using Newman-Keuls test when appropriate. P values <0.05 were considered significant. Animals subjected to hypoxia (8% oxygen for 1 h) spent significantly less time in the novel arm 1 day after the insult. The impairment, however, was transient. Hypoxic mice performance improved to the level of the control animals on the fourth post-treatment day. Mice subjected to hypoxia plus isoflurane exhibited no impairment and were comparable to the control group at all time points. Hypoxia transiently impairs performance in a spatial memory task. It appears that isoflurane protects against this deleterious effect of hypoxia.
PROCESSING MECHANISMS IN THE BIOSYNTHESIS OF PROTEINS* (1980)

Limited proteolysis is a widely occurring mechanism in protein biosynthesis. Protein precursors can be classified according to their functions, localization within cell compartments, and enzymic cleavage mechanisms. The presecretory proteins represent an important class of very rapidly turning over precursors which play an early role in the sequestration of secretory products and whose cleavage appears to be intimately associated with structures formed at the ribosome-membrane junction during protein synthesis. A model is proposed which predicts that the prepeptide forms a beta-pleated sheet structure with other components of the membrane which results in the transfer of a loop of peptide across the microsomal membrane. Proinsulin is representative of the general class of proproteins that are processed post-translationally within their secretory cells either during the formation and maturation of secretory granules (peptides hormones and neurotransmitters, serum albumins) or during the assembly of macromolecular structures (virus capsules, membrane-associated enzyme complexes). The former group are cleaved by Golgi-associated proteases having tryptic and carboxypeptidase B-like specificity. Some precursors are secreted as such and processed extracellularly either in the circulation or at special sites (procollagens, zymogens, provenoms, vitellogenins).
A software system for giving clues of medical diagnosis to clinician (2003)

The importance of developing a support system for medical decision-making in the clinical field has been pointed out for improving the accuracy and objectivity of the judgment of clinicians, and for early detection of disease. In this paper, we notice that signs, symptoms and clinical laboratory data are essential information which show the functional depression and failure of the ecosystem, and a practical software system is presented that provides physicians with clues to clinical diagnosis. First, by analysing the medical task and the structuralization of patient information, a medical modelling method is provided, where diagnosis can be considered as the identification of a patient who corresponds to the controlled object. Secondly, by using the concept of a patient model and a disease model, a system identification algorithm is proposed, and an actual system constructed for medical diagnosis is described in order to confirm the usefulness of the proposed method.
Influence of oxidative stress induced by cysteamine upon the induction and development of thermotolerance in Chinese hamster ovary cells. (1987)

Chinese hamster ovary cells exposed to the sulfhydryl compound cysteamine combined with heat treatment at 44 degrees C developed thermotolerance within 8 h. After initial treatment either with 15 min cysteamine (0.4 mM) at 37 degrees C immediately followed by 15 min heat at 44 degrees C or with 15 min cysteamine (0.4 mM) at 44 degrees C, the magnitude of thermotolerance developed was identical. The D0 of the subsequent 44 degrees C heat survival curves increased by factors of 8.9 and 7.9, respectively. The kinetics of thermotolerance induction and the time to reach the maximum of thermotolerance expression after combined cysteamine treatment at 44 degrees C for 15 min was found to be comparable to the effects of 44 degrees C treatment alone for 30 min. The synergistic effect of cysteamine with the conditioning heat treatment at 44 degrees C was blocked by catalase (50 micrograms/ml). Following initial treatment with cysteamine at 37 degrees C, cells became thermotolerant within 2 h. The D0 of the survival curves for 44 degrees C heat treatments increased with duration (t1 = min, 37 degrees C) of the cysteamine (0.4 mM) exposure; e.g., the D0 increased by factors of 1.5, 1.6, 2.2, and 2.6 for t1 = 30, 60, 90, and 120 min. The induction of thermotolerance by cysteamine at 37 degrees C was completely blocked by the addition of catalase (50 micrograms/ml), present during the initial period of drug treatment. Combined cysteamine and heat treatment at 44 degrees C, but also cysteamine exposure at 37 degrees C, enhanced synthesis of heat shock proteins. The data suggest that oxidative stress by cysteamine can be synergistic with the conditioning heat treatment at 44 degrees C which induces thermotolerance. At 37 degrees C, cysteamine itself induces thermotolerance and the enhanced synthesis of heat shock proteins under these conditions.
A Multi-Spectra Neutron Irradiation Technique for the Nondestructive Assay of Fissionable Materials (1971)

A technique has been developed for the nondestructive assay of fissionable materials which makes use of the variations with energy in the fission cross section for a given isotope in order to produce a signature characteristic of that isotope. The technique consists of irradiating the sample with neutrons from an accelerator and measuring the delayed-neutron response from the induced fission reactions in the sample. Different neutron irradiation energies were obtained by surrounding a 14-MeV neutron source with various moderating assemblies. Assay results obtained using this delayed-neutron technique include the following: (a) uranium samples with enrichments ranging from ∼3 to 98%; (b) plutonium-uranium oxides; (c) 233u-232Th salt mixtures; (d) “spent” reactor fuel elements; and (e) scrap containers ranging in size from small vials to one-gallon cans containing plutonium or uranium scrap. In addition, measurements have been made on the influence of various nonfissionable matrix materials on the assay results.
Mutations in Jewish patients with Gaucher disease (1992)

DNA from 100 unrelated patients, 97 of whom were Jewish and three half- Jewish, was analyzed for 22 mutations known to cause Gaucher disease. All but seven of the alleles were identified as having previously described mutations. Five of the unidentified mutations proved to be a previously undescribed nucleotide substitution in a splice junction (IVS2+1) that causes skipping of exon 2. Thus, only 2 of 197 alleles remained unidentified. Homozygotes for the most common mutation, that a nucleotide (nt) 1226, manifested, on average, the mildest disease and the latest age of onset. The mutation at nt 84 and the newly described IVS2+1 mutation, which do not produce any enzyme, were associated with earlier onset and more severe disease. Five of the mutations were considered to be “public,” in the sense that they were found in more than one unrelated individual. Screening for these five mutations permitted detection of 97.5% of all Gaucher alleles in this patient population. Because the mutation at nt 1226 is underrepresented in the patient population and because not all homozygotes come to medical attention, screening the Ashkenazi population using DNA analysis should detect approximately 99% of all heterozygotes.
The endocannabinoid system: emotion, learning and addiction (2008)

The identification of the cannabinoid receptor type 1 (CB1 receptor) was the milestone discovery in the elucidation of the behavioural and emotional responses induced by the Cannabis sativa constituent Delta(9)-tetrahydrocannabinol. The subsequent years have established the existence of the endocannabinoid system. The early view relating this system to emotional responses is reflected by the fact that N-arachidonoyl ethanolamine, the pioneer endocannabinoid, was named anandamide after the Sanskrit word 'ananda', meaning 'bliss'. However, the emotional responses to cannabinoids are not always pleasant and delightful. Rather, anxiety and panic may also occur after activation of CB1 receptors. The present review discusses three properties of the endocannabinoid system as an attempt to understand these diverse effects. First, this system typically functions 'on-demand', depending on environmental stimuli and on the emotional state of the organism. Second, it has a wide neuro-anatomical distribution, modulating brain regions with different functions in responses to aversive stimuli. Third, endocannabinoids regulate the release of other neurotransmitters that may have even opposing functions, such as GABA and glutamate. Further understanding of the temporal, spatial and functional characteristics of this system is necessary to clarify its role in emotional responses and will promote advances in its therapeutic exploitation.
Reduced-Complexity Receivers for Strongly Narrowband Intersymbol Interference Introduced by Faster-than-Nyquist Signaling (2012)

We propose new M-algorithm BCJR (M-BCJR) algorithms for low-complexity turbo equalization and apply them to severe intersymbol interference (ISI) introduced by faster than Nyquist signaling. These reduced-search detectors are evaluated in simple detection over the ISI channel and in iterative decoding of coded FTN transmissions. In the second case, accurate log likelihood ratios are essential and we introduce a 3-recursion M-BCJR that provides this. Focusing signal energy by a minimum phase conversion before the M-BCJR is also essential; we propose an improvement to this older idea. The new M-BCJRs are compared to reduced-trellis VA and BCJR benchmarks. The FTN signals carry 4-8 bits/Hz-s in a fixed spectrum, with severe ISI models as long as 32 taps. The combination of coded FTN and the reduced-complexity BCJR is an attractive narrowband coding method.
Fighting for fairness : racism and the media (2001)

Racism is institutionalised in the American media, argues Janine Jackson, by the under-representation of people of colour in US newsrooms by top-down reporting which favours those in power and by the commercialisation of news. It's time to demand major structural changes in the US media industry.
Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation. (2001)

Helicobacter pylori has been assigned as a class I carcinogen because of its relation to gastric adenocarcinoma. Chronic H. pylori infection may lead to severe gastritis, glandular atrophy (AT), and intestinal metaplasia (IM). Strains secreting the vacuolating toxin VacA and producing the cytotoxin-associated antigen CagA (type 1 strains), as well as the blood group antigen binding adhesin (BabA) targeting Lewis(b) antigens, have been associated previously with distal gastric adenocarcinoma (M. Gerhard et al., Proc. Natl. Acad. Sci. USA, 96: 12778-12783, 1999) and may therefore also be related to lesions preceding gastric cancer. Antral and corpus biopsies were collected from 451 patients; 151 were H. pylori positive, as determined by PCR. Gastric biopsies were histologically evaluated for activity of gastritis (G0-G3, granulocyte infiltration), chronicity of gastritis (L1-L3, lymphocyte infiltration), and the presence of IM and/or AT according to the Sydney classification. Simultaneously, the presence of bacterial genes encoding virulence and adherence factors (racAs1/s2, cagA, and babA2) was determined by PCR. The presence of cagA+ and vacAs1 (alone or combined) both correlated with activity and chronicity of gastritis (P < 0.05); however, the overall prevalence of these genes was 60 or 72%, respectively, and was thus relatively frequent. The babA2 gene, encoding the adhesin BabA, was detected in 38% of infected patients and was correlated with the activity of gastritis in antrum and corpus (P < 0.005). cagA+/vacAs1+ strains (suggesting the presence of type 1 strains) that were also babA2 positive were detected more frequently in patients with severe histological alterations (such as G3, IM, or AT) compared with subjects without these changes (P < 0.01). cagA+/vacAs1+ strains that were babA2 negative, however, lacked a significant correlation with severe histological changes, activity, or chronicity of gastritis in antrum and corpus. Adherence of H. pylori via BabA appears to be of importance for efficient delivery of VacA and CagA and may play a special role in the pathogenesis of severe histological changes.
Woven Fabric Engineering (2010)

The main goal in preparing this book was to publish contemporary concepts, new discoveries and innovative ideas in the field of woven fabric engineering, predominantly for the technical applications, as well as in the field of production engineering and to stress some problems connected with the use of woven fabrics in composites. The advantage of the book Woven Fabric Engineering is its open access fully searchable by anyone anywhere, and in this way it provides the forum for dissemination and exchange of the latest scientific information on theoretical as well as applied areas of knowledge in the field of woven fabric engineering. It is strongly recommended for all those who are connected with woven fabrics, for industrial engineers, researchers and graduate students.
Modeling and damping of high-frequency leakage currents in PWM inverter-fed AC motor drive systems (1996)

This paper presents an equivalent circuit for high-frequency leakage currents in pulsewidth modulation (PWM) inverter-fed AC motors, which forms a series resonant circuit. The analysis based on the equivalent circuit leads to such a conclusion that the connection of a conventional common-mode choke or reactor in series between the AC terminals of a PWM inverter and those of an AC motor is not effective to reduce the rms and average values of the leakage current, but effective to reduce the peak value. Furthermore, this paper proposes a common-mode transformer which is different in damping principle from the conventional common-mode choke. It is shown theoretically and experimentally that the common-mode transformer is able to reduce the rms value of the leakage current to 25%, where the core used in the common-mode transformer is smaller than that of the conventional common-mode choke.
Multiframe image super-resolution adapted with local spatial information (2011)

Super-resolution image reconstruction, which has been a hot research topic in recent years, is a process to reconstruct high-resolution images from shifted, low-resolution, degraded observations. Among the available reconstruction frameworks, the maximum a posteriori (MAP) model is widely used. However, existing methods usually employ a fixed prior item and regularization parameter for the entire HR image, ignoring local spatially adaptive properties, and the large computation load caused by the solution of the large-scale ill-posed problem is another issue to be noted. In this paper, a block-based local spatially adaptive reconstruction algorithm is proposed. To reduce the large computation load and realize the local spatially adaptive process of the prior model and regularization parameter, first the target image is divided into several same-sized blocks and the structure tensor is used to analyze the local spatial properties of each block. Different property prior items and regularization parameters are then applied adaptively to different properties' blocks. Experimental results show that the proposed method achieves better performance than methods with a fixed prior item and regularization parameter.
Testicular cells lysostripped of H-Y antigen organize ovarian follicle-like aggregates (1978)

A suspension of free testicular cells were obtained by mild trypsin treatment from newborn BALB/c testes, and their plasma membrane H-Y antigen sites were blocked (lysostripped) by an excess of H-Y antibody of proven specificity and potency (45 min in ice). Upon 16 h of the Moscona-type rotation culture, these treated testicular cells yielded primarily spherical aggregates, more than half of which demonstrated a strong resemblance to ovarian follicles. The resemblance was particularly striking between the smallest testicular folliculoids and primordial ovarian follicles that abound in the newborn female gonad. Under the same condition, control serum-treated testicular cells primarily yielded cylindrical tubular structures that can be very long. Over a critical range, concentrations of H-Y antibody apparently influenced the frequency of testicular folliculoid formation. The above directly supports the proposed testis-organizing function of H-Y antigen and is certainly compatible with the genetic situation encountered in the wood lemming (Myopus schisticolor), that in the functional absence of H-Y antigen, XY gonadal cells readily organize an ovary.
Reducing DRAM Row Activations with Eager Writeback (2012)

Headgroup volumes of seven dioleoyl lipid species, calculated from covalent radii, are shown to correlate linearly (r = 0.95) with the ability of those lipids to alter the midpoint temperature of the lamellar to inverted hexagonal phase transition (L alpha-->HII) of a 95 mole fraction percent phosphatidylethanolamine matrix. The results illustrate the utility of the shape concept and basic considerations of headgroup volume as a predictive tool for the determination of lipid structure.
Transcriptional repression: the long and the short of it (2001)

Gene-specific repression of transcription plays a central role in gene regulation. This is true for the spatial control of gene activity in development, during which boundaries of gene expression are often determined by the spatially restricted localization or activity of transcriptional repressors (Mannervik et al. 1999). It is also true for the control of gene expression by extracellular signals, in which genes are often maintained in an off state by repressor proteins until signal transduction alleviates the repression (e.g., Roose and Clevers 1999). One of the most useful ways of categorizing repressors is according to whether they mediate long-range or short-range repression (Gray and Levine 1996b). In longrange repression, a repressor makes a promoter resistant to the influence of all enhancers, even if those enhancers are located thousands of base pairs from the repressor binding site. This kind of repression is often referred to as silencing because an entire chromosomal locus is inactivated. In contrast, short-range repressors function in a less general manner. Rather than interfering with all transcription at a locus, they block the function of nearby DNA-bound activators while not interfering with more distantly bound activators. In this review, we discuss examples of both long-range and short-range repression, showing that long-range repression may often involve the assembly of a multiprotein complex termed a repressosome that is analogous in many ways to the enhanceosomes known to mediate activation. Furthermore, we discuss how both long-range and short-range repression may involve the recruitment of histone deacetylases to the template and discuss models that may allow these enzymes to mediate both types of repression. Finally, we consider the possibility that interactions between repressors and the basal machinery as well as between repressors and activators play roles in long-range and short-range repression.
Insulin secretion is regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor (1997)

Macrophage migration inhibitory factor (MIF), originally identified as a cytokine secreted by T lymphocytes, was found recently to be both a pituitary hormone and a mediator released by immune cells in response to glucocorticoid stimulation. We report here that the insulin-secreting beta cell of the islets of Langerhans expresses MIF and that its production is regulated by glucose in a time- and concentration-dependent manner. MIF and insulin colocalize by immunocytochemistry within the secretory granules of the pancreatic islet beta cells, and once released, MIF appears to regulate insulin release in an autocrine fashion. In perifusion studies performed with isolated rat islets, immunoneutralization of MIF reduced the first and second phase of the glucose-induced insulin secretion response by 39% and 31%, respectively. Conversely, exogenously added recombinant MIF was found to potentiate insulin release. Constitutive expression of MIF antisense RNA in the insulin-secreting INS-1 cell line inhibited MIF protein synthesis and decreased significantly glucose-induced insulin release. MIF is therefore a glucose-dependent, islet cell product that regulates insulin secretion in a positive manner and may play an important role in carbohydrate metabolism.
Functional Cloning of an Arabidopsis thalianacDNA Encoding Cycloeucalenol Cycloisomerase (2000)

Plants and certain protists use cycloeucalenol cycloisomerase (EC ) to convert pentacyclic cyclopropyl sterols to conventional tetracyclic sterols. We used a novel complementation strategy to clone a cycloeucalenol cycloisomerase cDNA. Expressing an Arabidopsis thaliana cycloartenol synthase cDNA in a yeast lanosterol synthase mutant provided a sterol auxotroph that could be genetically complemented with the isomerase. We transformed this yeast strain with an Arabidopsis yeast expression library and selected sterol prototrophs to obtain a strain that accumulated biosynthetic ergosterol. The novel phenotype was conferred by an Arabidopsis cDNA that potentially encodes a 36-kDa protein. We expressed this cDNA (CPI1) in Escherichia coli and showed by gas chromatography-mass spectrometry that extracts from this strain isomerized cycloeucalenol to obtusifoliol in vitro. The cDNA will be useful for obtaining heterologously expressed protein for catalytic studies and elucidating the in vivo roles of cyclopropyl sterols.