gebhart/patrepeval huggingface dataset:
A Unified Framework for Multi-View Multi-Class Object Pose Estimation (2018)

One core challenge in object pose estimation is to ensure accurate and robust performance for large numbers of diverse foreground objects amidst complex background clutter. In this work, we present a scalable framework for accurately inferring six Degree-of-Freedom (6-DoF) pose for a large number of object classes from single or multiple views. To learn discriminative pose features, we integrate three new capabilities into a deep Convolutional Neural Network (CNN): an inference scheme that combines both classification and pose regression based on a uniform tessellation of the Special Euclidean group in three dimensions (SE(3)), the fusion of class priors into the training process via a tiled class map, and an additional regularization using deep supervision with an object mask. Further, an efficient multi-view framework is formulated to address single-view ambiguity. We show that this framework consistently improves the performance of the single-view network. We evaluate our method on three large-scale benchmarks: YCB-Video, JHUScene-50 and ObjectNet-3D. Our approach achieves competitive or superior performance over the current state-of-the-art methods.
Accelerated cellular on- and off-target screening of bioactive compounds using microarrays (2015)

In situ proteome labeling was carried out with 9 drug-like probes in live mammalian cells, with the corresponding cellular targets captured on microarrays and simultaneously screened using a diverse set of antibodies, revealing potential on- and off-targets.
Using Geometry based Anomaly Detection to check the Integrity of IFC classifications in BIM Models (2017)

Although Industry Foundation Classes (IFC) provide standards for exchanging Building Information Modeling (BIM) data, authoring tools still require manual mapping between BIM entities and IFC classes. This leads to errors and omissions, which results in corrupted data exchanges that are unreliable and thus compromise the validity of IFC. This research explored precedent work by Krijnen and Tamke, who suggested ways to automate the mapping of IFC classes using a machine learning technique, namely anomaly detection. The technique incorporates geometric features of individual components to find outliers among entities in identical IFC classes. This research primarily focused on applying this approach on two architectural BIM models and determining its feasibility as well as limitations. Results indicated that the approach, while effective, misclassified outliers when an IFC class had several dissimilar entities. Another issue was the lack of entities for some specific IFC classes that prohibited the anomaly detection from comparing differences. Future research to improve these issues include the addition of geometric features, using novelty detection and the inclusion of a probabilistic graph model, to improve classification accuracy.
Basset: learning the regulatory code of the accessible genome with deep convolutional neural networks (2016)

The complex language of eukaryotic gene expression remains incompletely understood. Despite the importance suggested by many noncoding variants statistically associated with human disease, nearly all such variants have unknown mechanisms. Here, we address this challenge using an approach based on a recent machine learning advance-deep convolutional neural networks (CNNs). We introduce the open source package Basset to apply CNNs to learn the functional activity of DNA sequences from genomics data. We trained Basset on a compendium of accessible genomic sites mapped in 164 cell types by DNase-seq, and demonstrate greater predictive accuracy than previous methods. Basset predictions for the change in accessibility between variant alleles were far greater for Genome-wide association study (GWAS) SNPs that are likely to be causal relative to nearby SNPs in linkage disequilibrium with them. With Basset, a researcher can perform a single sequencing assay in their cell type of interest and simultaneously learn that cell's chromatin accessibility code and annotate every mutation in the genome with its influence on present accessibility and latent potential for accessibility. Thus, Basset offers a powerful computational approach to annotate and interpret the noncoding genome.
Motion into mass: how does tension stimulate muscle growth? (1987)

Tension is an important regulator of skeletal muscle hypertrophy in vivo. When increased constant tension is applied to embryonic skeletal muscle fibers differentiated in a tissue culture environment, many of the same biochemical processes associated with muscle hypertrophy in vivo are also stimulated in vitro, e.g., sodium-dependent amino acid transport, Na+,K+-ATPase (sodium pump) activity, protein synthesis, total protein, and myosin heavy chain accumulation. The molecular mechanisms by which tension induces these growth-related changes are unknown, but several models have been tested using whole animal, organ-cultured muscle, and tissue culture model systems. In tissue culture, activation of the plasma membrane sodium pump is closely coupled to, and essential for, stretch and serum-induced skeletal muscle growth. Long-term membrane hyperpolarization is not associated with this sodium pump activation, and muscle growth in vitro is unrelated to the myotube's resting membrane potential, since growth can occur under de-polarizating conditions. Medium growth factors are essential for stretch-induced muscle growth in tissue culture. In medium without growth factor supplements, stretch is able to reduce the rate of atrophy of the cultured muscle cells which are in negative nitrogen balance, but the muscle cells are unable to grow in response to stretch without the presence of some as yet undefined growth factor or factors present in serum. As newer tissue culture environments are designed for growing embryonic skeletal muscle under more in vivo-like conditions, a more complete analysis of the mechanisms by which a physical stimulus (tension) is translated into the biochemical alterations leading to muscle growth will be possible.(ABSTRACT TRUNCATED AT 250 WORDS)
miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4 (2012)

Metastasis is the major cause of poor prognosis in colorectal cancer (CRC), and increasing evidence supports the contribution of miRNAs to cancer progression. Here, we found that high expression of miR-103 and miR-107 (miR-103/107) was associated with metastasis potential of CRC cell lines and poor prognosis in patients with CRC. We showed that miR-103/107 targeted the known metastasis suppressors death-associated protein kinase (DAPK) and Krüppel-like factor 4 (KLF4) in CRC cells, resulting in increased cell motility and cell-matrix adhesion and decreased cell-cell adhesion and epithelial marker expression. miR-103/107 expression was increased in the presence of hypoxia, thereby potentiating DAPK and KLF4 downregulation and hypoxia-induced motility and invasiveness. In mouse models of CRC, miR-103/107 overexpression potentiated local invasion and liver metastasis effects, which were suppressed by reexpression of DAPK or KLF4. miR-103/107-mediated downregulation of DAPK and KLF4 also enabled the colonization of CRC cells at a metastatic site. Clinically, the signature of a miR-103/107 high, DAPK low, and KLF4 low expression profile correlated with the extent of lymph node and distant metastasis in patients with CRC and served as a prognostic marker for metastasis recurrence and poor survival. Our findings therefore indicate that miR-103/107-mediated repression of DAPK and KLF4 promotes metastasis in CRC, and this regulatory circuit may contribute in part to hypoxia-stimulated tumor metastasis. Strategies that disrupt this regulation might be developed to block CRC metastasis.
Quantitation and stability of piperacillin and tazobactam in plasma and ultrafiltrate from patients undergoing continuous venovenous hemofiltration by HPLC (2005)

Simple and reproducible HPLC methods for the determination of piperacillin and tazobactam have been developed and a complete stability study carried out. The method for piperacillin plasma samples consisted of protein precipitation with methanol using penicillin G as internal standard. No sample preparation was needed for ultrafiltrate samples. Tazobactam sample preparation involved protein precipitation with acetonitrile and the removal of lipids with dichloromethane. Piperacillin separation was performed on a microBondapack C(18) column (300 x 3.9, 10 microm) and tazobactam on a Novapack C(18) column (150 x 3.9, 4 microm) with UV detection set at 229 and 225 nm, respectively. The mobile phase consisted of phosphate buffer-acetonitrile, delivered at 1.5 mL[sol ]min. Calibration curves determination coefficients were >or=0.999 and response factors CV% < 5%. Intra- and inter-assay precision and accuracy of the quality control and limit of quantification were satisfactory. Plasma and ultrafiltrate samples were stable at -20 and -80 degrees C for 2 months and after three freeze-thaw cycles. In the chromatographic rack, tazobactam ultrafiltrate samples were stable for 24 h and plasma samples for 12 h, piperacillin ultrafiltrate samples for 8 h, but plasma samples for only 4 h. Storage of piperacillin samples at 4 degrees C until analysis is recommended. Piperacillin was stable in the presence of tazobactam.
An epidemiologic study of Tourette's syndrome in a single school district. (1990)

To evaluate the frequency of Gilles de la Tourette's syndrome (TS) in children, 3034 students in three schools in a single school district in greater Los Angeles were monitored frequently over a 2-year period by a school psychologist thoroughly familiar with the symptoms of the disorder. A portion of the cases were also evaluated in a TS clinic. A total of 14 males fulfilled the Tourette Syndrome Association research criteria for definite TS. When corrected for the number of students in special education classes in the monitored schools, the frequency of definite TS in males was 1 in 152. An additional 7 males who differed only in that they were not observed for a full year were termed definite TS less than 1 year. When the two groups were combined, the frequency of definite TS was 1 in 95 for males and 1 in 759 for females. These figures do not include an additional 10 males diagnosed as having definite transient tic disorder, 2 males diagnosed as having probable TS, and 10 males diagnosed as having possible TS. In addition to tics, most of these children had problems with attention span, obsessive compulsive behavior, and learning and/or conduct disorders. Seventy percent of the students with definite TS or definite TS less than 1 year were in special education classes. Twelve percent of the children in special education classes had definite TS or definite TS less than 1 year, and 28% were in one of the diagnostic categories of definite, probable, or possible. All of the 10 definite TS patients that were seen in the clinic had attention-deficit hyperactivity disorder.(ABSTRACT TRUNCATED AT 250 WORDS)
Post-activation Turn-off of NF-κB-dependent Transcription Is Regulated by Acetylation of p65 (2003)

NF-kappaB represents a family of eukaryotic transcription factors participating in the regulation of various cellular genes involved in the immediate early processes of immune, acute-phase, and inflammatory responses. Cellular localization and consequently the transcriptional activity of NF-kappaB is tightly regulated by its partner IkappaBalpha. Here, we show that the p65 subunit of NF-kappaB is acetylated by both p300 and PCAF on lysines 122 and 123. Both HDAC2 and HDAC3 interact with p65, although only HDAC3 was able to deacetylate p65. Acetylation of p65 reduces its ability to bind kappaBeta-DNA. Finally, acetylation of p65 facilitated its removal from DNA and consequently its IkappaBetaalpha-mediated export from the nucleus. We propose that acetylation of p65 plays a key role in IkappaBetaalpha-mediated attenuation of NF-kappaBeta transcriptional activity which is an important process that restores the latent state in post-induced cells.
翻译与翻译原型 = Translation and its prototype (2011)

长期以来，翻译研究一直受传统的经典范畴观影响，翻译理论中盛行着无数的二元对立观，如直译与意译、形式与意义、形似与神似、异化与归化、忠实与不忠实、可译与不可译、翻译作为艺术与翻译作为科学等等互相冲突的思想与方法。对翻译本质的这种认识方式，使人们在对同一问题进行分析时，容易各执一端，争论不休。原型理论则与之相反，它跳脱对范畴认知的二元对立模式，强调范畴的原型性和范畴边界的模糊性，因而在很大程度上克服了二元对立观非此即彼的认知缺陷。本文立足于近年认知科学领域甚为流行的原型理论，围绕“翻译原型”这个主题，就翻译范畴属性、翻译标准、翻译本体及其本体理论等若干关涉翻译本质的核心问题展开讨论，以期引起学界同仁对相关研究课题的关注。
The Visual Story: Creating the Visual Structure of Film, TV and Digital Media (2001)

This updated edition of a best-selling classic shows you how to structure your visuals as carefully as a writer structures a story or composers structure their music. The Visual Story teaches you how to design and control the structure of your production using the basic visual components of space, line, shape, tone, color, movement, and rhythm. You can use these components to effectively convey moods and emotions, create a visual style, and utilize the important relationship between the visual and the story structures.

Using over 700 color illustrations, author Bruce Block explains how understanding the connection between story and visual structures will guide you in the selection of camera angles, lenses, actor staging, composition, set design and locations, lighting, storyboard planning, camera coverage, and editing. 

The Visual Story is an ideal blend of theory and practice. The concepts and examples in this new edition will benefit students learning cinematic production, as well as professional writers, directors, cinematographers, art directors, animators, game designers, and anyone working in visual media who wants a better understanding of visual structure.
“Beyond the Boundary” (2015)

Sun Village, located in a remote part of coastal Fujian, has a tradition of migratory economic activities supplementary to agriculture—a tradition that could be called tongxiang tongye (same hometown, same trade). On the basis of rural social networks, Sun villagers have established an industry processing golden and silver jewelry in cities throughout China. This phenomenon is a countermovement against the predominant trend of rural China’s marginalization and “hollowing-out” relative to urban centers. This countermovement offers the possibility of reembedding economic activities within social relationships to create a “social economy.” Jiewai (“Beyond the Boundary”) is an alternative and pluralistic periphery that might undermine the center.
Immunoreactive Inhibin<i>α</i>-Subunit in Human Serum: Implications for Radioimmunoassay* (1990)

The specificity of the most widely used heterologous RIA for human serum inhibition was examined with regard to its cross-reactivity with the alpha-subunit of inhibin. Using a mixture of recombinant alpha inhibin proteins, including precursor and mature forms, the epitopic specificity of this antibody was localized entirely to the alpha-subunit. Furthermore, varying degrees of alpha inhibin immunoactivity were demonstrated in serum from normal subjects and patients with various reproductive disorders by both Western blot and RIA. These results demonstrate that data obtained using this RIA should be interpreted with caution as to the degree to which they reflect the presence of intact dimeric inhibin vs. alpha inhibin proteins in the circulation.
Electronic Warfare in the Information Age (1999)

From the Publisher:
Here's an advanced practitioner's guide to the latest concepts and threats associated with modern electronic warfare (EW). This new book identifies and explains the newest radar and communications threats, and provides EW and radar engineers, managers, and technical professionals with practical, how-to information on designing and implementing ECM and ECCM systems.

Written by a world-renowned expert in radar and electronic warfare, the book helps you develop state-of-the-art ESM systems designed specifically to exploit the vulnerabilities of modern radar. It also identifies and evaluates the latest ESM receiving equipment, and outlines advanced ECM methods, including monopulse deception, coherent radar jamming, and high-ERP generation. Other well-structured sections cover modern ECCM countermeasure techniques, the impact of new stealth technology on ESM and ECM requirements, jammer upgrading procedures, and much more.
Synthese und Pharmakodynamische Aktivität von 2‐(3‐(2‐Phenylethyl)benzofuran‐2‐yl)‐<i>N</i>‐propyl‐ethanamin (1995)

The benzofuranethanamines 3a and 3b were synthesized and pharmacologically tested to investigate structure-activity relationships with antiarrhythmic compounds. The key-step in the synthesis was the chemoselective reduction of the chloroacetyl-dihydrobenzofurane 5 to chloroethylbenzofurane 9 using triethylsilane/BF3.Et2O. Results of a series of further attempts to reduce 5 are also described. Pharmacological investigations on isolated guinea pig heart muscle preparations showed that 3a exhibits similar negative inotropic and negative chronotropic action in comparison to propafenone and the conformationally restricted benzofurane 1a. In contrast to these substances, however, 3a shows no beta 1-adrenoreceptor blocking activity.
Design and Implementation of PCB Inductors With Litz-Wire Structure for Conventional-Size Large-Signal Domestic Induction Heating Applications (2014)

Printed circuit board (PCB) implementations provide high repeatability and ease of manufacturing as well as potential cost savings for many applications. An optimization procedure is proposed for designing PCB inductors for use in domestic induction cooktops. Cables for classical inductors are built of multistranded round litz wire for efficiency reasons. A planar litz structure in a PCB has been applied to achieve a similar performance to that of traditional constructions (in terms of maximum output power, inductive efficiency, and thermal behavior). The inductor performance has been optimized by a finite-element-analysis-tool-based method taking into account the power losses in rectangular cross-sectional tracks of the cable as well as the geometrical constraints of PCB implementations and the requirements of the associated electronics. Finally, the proposed method has been validated by means of experimental measurements under large-signal conditions on a PCB inductor prototype.
Comparative study of iterative reconstruction algorithms for missing cone problems in optical diffraction tomography (2015)

In optical tomography, there exist certain spatial frequency components that cannot be measured due to the limited projection angles imposed by the numerical aperture of objective lenses. This limitation, often called as the missing cone problem, causes the under-estimation of refractive index (RI) values in tomograms and results in severe elongations of RI distributions along the optical axis. To address this missing cone problem, several iterative reconstruction algorithms have been introduced exploiting prior knowledge such as positivity in RI differences or edges of samples. In this paper, various existing iterative reconstruction algorithms are systematically compared for mitigating the missing cone problem in optical diffraction tomography. In particular, three representative regularization schemes, edge preserving, total variation regularization, and the Gerchberg-Papoulis algorithm, were numerically and experimentally evaluated using spherical beads as well as real biological samples; human red blood cells and hepatocyte cells. Our work will provide important guidelines for choosing the appropriate regularization in ODT.
Ferroelectric Properties of Mn-substituted BiFeO<sub>3</sub> Thin Film on Ir Electrodes (2007)

In this study, ferroelectric properties and fatigue endurance of 5% Mn-substituted BiFeO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (BFO) films deposited on Iridium (Ir) and Platinum (Pt) electrodes were discussed. 5% Mn-substituted BFO thin films were formed on Ir(Pt)/Ti/SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Si(100) substrates by chemical solution deposition (CSD). XRD patterns proved that BFO films on both Ir and Pt electrodes have distorted rhombohedral R3c structure. Leakage current in BFO films on Ir electrode increased because of the lower Schottky barrier height than Pt. Remanent polarization (Pr) and coercive electric field in BFO films on Ir electrode were 82 <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">μ</i> C/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 0.4 MV/cm respectively at an applied electric field of 2.2MV/cm and a measurement frequency of 10 kHz. In the fatigue endurance measurement in a BFO film on Ir electrode degradation of Pr (55 <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">μ</i> C/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) was negligible up to 4.7×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> polarization reversal cycles.
Scaling and applied field studies of MPD thrusters with laser diagnostics (1992)

The topics are presented in viewgraph form and include the following: self-field magnetoplasmadynamics; 1/4-scale applied-field MPD; scaling of arcs and MPD-arcs; magnetic nozzle studies; advanced diagnostic techniques needed for obtaining particle velocity, temperature, and current distributions in plasma thrusters; nonintrusive laser diagnostics for arcs and MPD-arcs; and schematic of multi-beam interferometer for electron density profile determination.
Antimicrobial activity of phenothiazines. (2005)

Multidrug-resistant Mycobacterium tuberculosis (MDRTB) and antibiotic-resistant Plasmodium falciparum are the major global lethal infections accounting for over 4 million deaths per year. Methicillin-resistant Staphylococcus aureus (MRSA) is the major global nosocomial infection and resistance to vancomycin is evident and may become common. This review provides the scientific and medical basis that support the use of one particular group of compounds, the phenothiazines, and in particular thioridazine, for the management of the above antibiotic-resistant infections. Because thioridazine, a relatively mild neuroleptic as compared to its parental compound chlorpromazine, kills intracellular MDRTB and MRSA at clinical concentrations, its use for the management of these infections may be considered. The review also discusses the activity of phenothiazines against protozoa and parasites, the mechanisms by which phenothiazines promote their antimicrobial effects, their potential for regulating efflux pumps that are a cause for mono or multidrug resistance, as well as their potential for the therapy of problematic infections caused by bacteria that have acquired plasmid-antibiotic-resistant genes.
Terahertz scattering from granular material (2007)

Terahertz (THz) imaging is emerging as a potentially powerful method of detecting explosive devices, even in the presence of occluding materials. However, the characteristic spectral signatures of pure explosive materials may be altered or obscured by electromagnetic scattering caused by their granular nature. This paper presents THz transmission measurements of granular systems representative of explosives and presents results from dense media theory that accurately explain the observed scattering response.