gebhart/patrepeval huggingface dataset:
Recombinant lemA without adjuvant induces extensive expansion of H2-M3-restricted CD8 effectors, which can suppress primary listeriosis in mice (2002)

Mice infected with Listeria monocytogenes (LM) produce large numbers of H2-M3-restricted CD8 T cells directed against the formylated peptides, f-MIGWII and f-MIVIL. To examine responsiveness to these epitopes in the absence of infection, we inoculated mice with recombinant lemA (r-lemA) containing f-MIGWII or r-vemA (a variant of r-lemA containing f-MIVIL in place of f-MIGWII) without adjuvant. To monitor responses, we measured peptide-specific cytoplasmic IFN-gamma production ex vivo by freshly harvested splenocytes at varying times post-inoculation. B6 mice inoculated with r-lemA produced substantial numbers of epitope-specific CD8 cells with peak levels on day 7 when there were 1.1 x 10(6) f-MIGWII-specific CD8 cells in the spleen (8.2% of total CD8 splenocytes). The r-vemA-treated animals accumulated 0.25 x 10(6) cells (1.8% of total CD8 cells) at this time point. Comparable responses were observed after rechallenge of immunized animals. Other elements in the lemA moiety distinct from the immunogenic peptide were required since mice did not respond to equimolar amounts of synthetic f-MIGWII or f-MIVIL alone. In comparative studies, B6 and C3H/HeJ mice responded to r-lemA much more vigorously than BALB/c animals. When r-lemA- or r-vemA-treated B6 animals were challenged i.v. with LM 7 days later, they suppressed splenic accumulation of bacteria much more effectively than controls. On the other hand, antigen-treated animals were not protected against infection 1 month later. Thus, responsive strains of mice respond vigorously to H2-M3-restricted epitopes, even in the absence of bacterial infection or adjuvant. The resulting effectors acutely enhance antimicrobial resistance but do not confer long-term memory protection.
Synthesis of Morphine-3,6-di-β-D-glucuronide (1997)

The synthesis of morphine-3,6-di-β-D-glucuronide as the monolithium salt from a fully protected morphine-6-β-D-glucuronide 12 via selective 3-deacetylation followed by Lewis acid-catalyzed 3-glucuronidation, and stepwise deprotection with lithium hydroxide is described.
Effect of pre-treatment on the surface and electrochemical properties of screen-printed carbon paste electrodes (2001)

The effect of various electrochemical pre-treatment methods on the surface and electrochemical properties of screen-printed carbon paste electrodes (SPCE) prepared with three different commercial products was examined. It was observed that a positively charged redox couple, e.g., hexaammineruthenium(III), exhibited quasi-reversible behavior at the untreated SPCE. However, the cyclic voltammograms (CVs) of the SPCE prepared with general-purpose carbon inks did not exhibit clear redox peaks to other representative redox couples [e.g., hexacyanoferrate(III), hexachloroiridate(IV), dopamine, and hydroquinone] without activation. Electrochemical pre-treatment methods were sought in four different aqueous solutions, i.e., sulfuric acid, potassium chloride, sodium hydrogencarbonate, and sodium carbonate, applying various activation potentials. It was found that the pre-treatment procedure in saturated Na2CO3 solution at 1.2 V provides a mild and effective condition for activating the SPCE. By measuring the water contact angles at the SPCE surfaces and recording their SEM images, it was confirmed that the electrochemical pre-treatment effectively removes the organic binders from the surface carbon particles. A prolonged period of activation (>5 min) or the use of high potentials (>1.2 V) increased the capacitance of the electrode over 20 μF cm−2. The pre-treated SPCE behaved like a random array microelectrode, exhibiting a sigmoidal-shaped CV at a slow scan rate. The short pre-anodization method in Na2CO3 solution was generally applicable to most SPCE prepared with general-purpose carbon inks.
One-Pot Synthesis of Benzofurans via Palladium-Catalyzed Enolate Arylation with <i>o</i>-Bromophenols (2008)

A one-pot synthesis of benzofurans which utilizes a palladium-catalyzed enolate arylation is described. The process demonstrates broad substrate scope and provides differentially substituted benzofurans in moderate to excellent yields. The utility of the method is further demonstrated by the synthesis of the natural product eupomatenoid 6 in three steps.
Evaluation of absolute quantitation by nonlinear regression in probe-based real-time PCR (2006)

NLR can be automated for batch production analysis, but the CT method is more precise for absolute quantitation in the present setting. The observed inter-method deviation is an indication that assessment of the fluorescence conversion factor used in the regression method can be improved. However, the versatility depends on the level of precision required, and in some settings the increased cost effectiveness of NLR may justify the lower precision.
EABS: An Event-Aware Backpressure Scheduling Scheme for Emergency Internet of Things (2017)

The backpressure scheduling scheme has been applied in Internet of Things, which can control the network congestion effectively and increase the network throughput. However, in large-scale Emergency Internet of Things (EIoT), emergency packets may exist because of the urgent events or situations. The traditional backpressure scheduling scheme will explore all the possible routes between the source and destination nodes that cause a superfluous long path for packets. Therefore, the end-to-end delay increases and the real-time performance of emergency packets cannot be guaranteed. To address this shortcoming, this paper proposes EABS, an event-aware backpressure scheduling scheme for EIoT. A backpressure queue model with emergency packets is first devised based on the analysis of the arrival process of different packets. Meanwhile, EABS combines the shortest path with backpressure scheme in the process of next-hop node selecting. The emergency packets are forwarded in the shortest path and avoid the network congestion according to the queue backlog difference. The extensive experiment results verify that EABS can reduce the average end-to-end delay and increase the average forwarding percentage. For the emergency packets, the real-time performance is guaranteed. Moreover, we compare EABS with two existing backpressure scheduling schemes, showing that EABS outperforms both of them.
Design of a narrow-band reflection IR multilayer (1983)

This paper describes a design method for a narrow-band reflection filter with metal layers. The principle used is the theory of induced transmission, with the help of graphic displays. The conditions, at which the maximum values of the reflectance, the potential transmittance, and the energy transmittance of the filter occur simultaneously when the absorptance reaches a minimum at the design frequency, are described. Several designs of high reflection filters with narrow bandwidths in the IR region are presented.
Qualitative and quantitative analysis of phenolic acids in Asclepias syriaca L. (2000)

TLC and HPLC was applied to qualitative and quantitative determination of phenolic acids free and liberated by acid and alkaline hydrolysis in common milkweed. The presence of phenolic acids, namely p-hydroxybenzoic, p-coumaric, protocatechuic and caffeic acids, was confirmed in the leaves and flowers. Moreover, the flowers contained gallic acid, and the leaves contained alpha-resorcylic, vanilic and chlorogenic acids. Conjugated forms of phenolic acids predominate in the plant. They hydrolyse mainly to coffeic, p-coumaric, ferulic and p-hydroxybenzoic acids.
Average Sum-Rate Bound of Multiuser MIMO Beamforming with Direction-Indicating Matrices and Channel Magnitude Feedback (2008)

In this paper, we investigate sum-rate bounds for a multiuser beamforming system with feedbacks of direction- indicating (DI) matrices and channel magnitudes. We also adopt a quality-based channel state reporting (QBR) in order to reduce the feedback load in multiuser environments. With QBR, the users with SNR higher than a predefined threshold are allowed to send the feedback information. The feedback consists of only two numbers: a positive real value for the channel magnitude and a positive integer for the index of DI vector. A semi-orthogonal user group and the corresponding beamforming matrix are then constructed by a user selection process using the indices of DI vector. Finding an optimal beamforming matrix is generally known as a difficult nonconvex optimization problem, but using DI matrices may greatly reduce the complexity although there exists some loss on the sum-rate. We obtain upper and lower bounds of the average sum-rate of the proposed scheme and compare the performance with that of an established ZFBF scheme in [1]. Numerical results show that these bounds are valid and the proposed method achieves better performance than the ZFBF scheme when the available feedback bandwidth is small (i.e., the number of mini slots in this paper). And very low feedback-rate also can be obtained especially for a large number of users.
Quantitative structure-activity studies on monoamine oxidase inhibitors (1976)

Quantitative structure-activity studies were carried out on a series of N-isopropylaryl hydrazides which inhibits monoamine oxidase (MAO). The inhibitory potencies of these compounds of MAO were found to correlate with the electron-withdrawing capacity of the aryl ring substituents as estimated by both empirical Hammet sigma constants and electronic indices from molecular orbital calculations. Based on these correlations and previously published data on other classes of MAO inhibitors, a general model for the inhibitor pharmacophore is proposed: potent MAO of an aromatic ring; electron-withdrawing groups on the aromatic ring or replacing the phenyl ring with certain types of heterocyclic rings will tend to increase the potency.
Machine Learning Predictions of Molecular Properties: Accurate Many-Body Potentials and Nonlocality in Chemical Space (2015)

Simultaneously accurate and efficient prediction of molecular properties throughout chemical compound space is a critical ingredient toward rational compound design in chemical and pharmaceutical industries. Aiming toward this goal, we develop and apply a systematic hierarchy of efficient empirical methods to estimate atomization and total energies of molecules. These methods range from a simple sum over atoms, to addition of bond energies, to pairwise interatomic force fields, reaching to the more sophisticated machine learning approaches that are capable of describing collective interactions between many atoms or bonds. In the case of equilibrium molecular geometries, even simple pairwise force fields demonstrate prediction accuracy comparable to benchmark energies calculated using density functional theory with hybrid exchange-correlation functionals; however, accounting for the collective many-body interactions proves to be essential for approaching the “holy grail” of chemical accuracy of 1 kcal/mol for both equilibrium and out-of-equilibrium geometries. This remarkable accuracy is achieved by a vectorized representation of molecules (so-called Bag of Bonds model) that exhibits strong nonlocality in chemical space. In addition, the same representation allows us to predict accurate electronic properties of molecules, such as their polarizability and molecular frontier orbital energies.
Structural mechanism of pyroelectricity in tourmaline (1977)

Pyroelectricity in tourmaline, known since antiquity, was ascribed by S. von Boguslawski to a charged, asymmetric, anharmonic oscillator based on the Einstein model of a crystal. His predicted values of the pyroelectric coefficient k were in good agreement with Ackermann's measurements in the range 20-400 K. We have tested Boguslawski's model by refining the structure, at 193 and 293 K, on a sphere of gem-quality elbaite. The pyroelectric effect is due primarily to the asymmetric anharmonic vibrations of O(1), the oxygen atom of point symmetry 3m which has a polar environment. Its centre of gravity moves 0.005 Å from 193 to 293 K. It is the only atom with a displacement well above experimental uncertainty. Its large thermal parameters, which are ten times their standard deviation at both temperatures, clearly invalidate the assumption of an ellipsoidal thermal movement. This probably holds for Na and 0(2), which also have abnormally large temperature factors, but show no significant displacement.
Dielectric relaxation of the crystal-amorphous interphase in poly(vinylidene fluoride) and its blends with poly(methyl methacrylate) (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDielectric relaxation of the crystal-amorphous interphase in poly(vinylidene fluoride) and its blends with poly(methyl methacrylate)Bernd Hahn, Joachim Wendorff, and Do Y. YoonCite this: Macromolecules 1985, 18, 4, 718–721Publication Date (Print):April 1, 1985Publication History Published online1 May 2002Published inissue 1 April 1985https://pubs.acs.org/doi/10.1021/ma00146a024https://doi.org/10.1021/ma00146a024research-articleACS PublicationsRequest reuse permissionsArticle Views744Altmetric-Citations172LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Radiometric and Geometric Calibration of a Visible Spectral Electro-Optic “Fisheye” Camera Radiance Distribution System (1989)

Camera systems which measure a complete hemispherical field (“fisheye” lens systems), can be applied to the measurement of the radiance, but accurate radiometric and geometric calibrations are required to obtain absolute radiance data. The calibration procedure applied to an instrument built for spectral and geometrical radiance distribution measurements in the visible wavelength region (450–650 nm), based on an electro-optic fisheye camera system, is described and validated through comparison with a mere standard radiometer.
Sliding Mode Control with Velocity Feedforward Gain of a Pneumatic Motor (2006)

In this study, the performance of the tracking control of a pneumatic servo motor driven position control system using sliding mode is investigated. It is usually quite difficult to obtain precise tracking control of a pneumatic servo motor driven position control system because of the nonlinear deadband and stick-slip friction of the proportional valve. Therefore, a continuous sliding mode controller with velocity feedforward gain is proposed. Experimental results show that the tracking accurracy can be remarkably improved by adding a proper velocity feedforward term to continuous sliding mode controller.
Markov tree model of transport in area preserving maps (1985)

Abstract Transport in an area-preserving map with a mixture of regular and chaotic regions is described in terms of the flux through invariant cantor sets called cantori. A model retaining a discrete set of cantori approaching a boundary circle gives the Markov chain description of Hanson, Cary and Meiss. The inclusion of cantori surrounding island chains, and islands about islands, etc. gives a Markov tree model with a slower decay rate. The survival probability distribution is shown to decay asymptotically as a power law. The decay exponent agrees reasonably well with the computations of Karney and of Chirikov and Shepelyanski.
Efficient image browsing with JPEG2000 internet protocol (2004)

The JPEG2000 image compression standard provides many features to support interactive access to large images. These include efficient lossless and lossy compression, resolution scalability, quality scalability, region of interest coding and spatial random access. The ISO/IEC JPEG committee is in the process of finalizing the JPEG2000 Internet Protocol (JPIP) standard for interacting with JPEG2000 files. JPIP is tightly coupled to JPEG2000 and provides a powerful and flexible client-server architecture. By combining JPIP and JPEG2000 it is possible to store only one compressed file at the server and transmit the resolution, quality, and Window Of Interest (WOI) specified by the client, without having to transmit or decode the entire code-stream. This minimizes server computation, storage and bandwidth. It also reduces the latency for the client. By sending only the data that the client needs the effective compression ratio for client-server applications can be much higher than the file size compression ratio. A prototype JPIP client/server implementation is used to demonstrate resolution scalability, quality scalability and spatial random access of medical images. Efficiency, latency improvements and PSNR quality of the received images are measured as a function of the number of bytes transferred from the server to the client. The choice of JPEG2000 compression parameters, such as precincts and tiles, and the trade-offs of stateful and stateless sessions are discussed. The inclusion of radiology reports as metadata in image files is also demonstrated.
Gemifloxacin once daily for 5 days versus 7 days for the treatment of community-acquired pneumonia: a randomized, multicentre, double-blind study (2007)

Gemifloxacin once daily for 5 days is not inferior to 7 days in the PP population with respect to clinical, bacteriological and radiological efficacy. Further work is needed, however, to explore whether fewer treatment days would improve patient compliance and reduce the incidence of AEs.
Network coding based reliable and efficient data transfer for Smart Grid monitoring (2013)

In this paper, we present a bandwidth-efficient data reliability mechanism for Smart Grid Wide-Area Monitoring communication networks. Reliable transmission of data packets, especially feedback control packets, is deemed a critical requirement. By sending multiple copies of data packets on node or edge disjoint paths, reliability can be achieved. However, this is inefficient in terms of bandwidth usage. We present a network-coding based algorithm that can reduce the bandwidth requirement while improving data reliability by combining multi-path transmissions and network-coding techniques. The performance of the mechanisms has been studied using discrete-event simulation models. The simulation results show that the proposed mechanism reduces the bandwidth requirement by 65-82% while achieving nearly 100% reliability, compared to existing multi-path redundancy mechanism.
The role of Artificial Intelligence (AI) in making accurate stock decisions in E-commerce industry (2018)

With accumulation and proliferation of large data, it is highly necessary to make some meaningful sense out of the data. Here is where Artificial Intelligence (AI) tools and algorithms play a major role. AI is highly expertise in handling the customer data and forecasting the purchase behavior of customers. This has brought out the biggest level of automation in the e-commerce industry. AI provide notification when a company has to re-order stock and assist in creating manufacturing schedule as per the variation in demand during the particular period of time accurately. The autonomous and data-driven supply chain has optimized logistics, manufacturing, warehousing and the last mile delivery. E-commerce giant like Amazon use leads to time and forecasting techniques to critically plan inventory orders. Machine learning system (MLS), a subset of AI solves the cognitive problems associated with human intelligence and helps to optimize logistic speed and quality. This paper discusses AI-based inventory management tools which are being utilized in the e-commerce industry. AI provides customers an enriched experience which helps to maximize profits.
Do changes in climate patterns in wintering areas affect the timing of the spring arrival of trans‐Saharan migrant birds? (2004)

Abstract The life cycles of plants and animals are changing around the world in line with the predictions originated from hypotheses concerning the impact of global warming and climate change on biological systems. Commonly, the search for ecological mechanisms behind the observed changes in bird phenology has focused on the analysis of climatic patterns from the species breeding grounds. However, the ecology of bird migration suggests that the spring arrival of long‐distance migrants (such as trans‐Saharan birds) is more likely to be influenced by climate conditions in wintering areas given their direct impact on the onset of migration and its progression. We tested this hypothesis by analysing the first arrival dates (FADs) of six trans‐Saharan migrants (cuckoo Cuculus canorus , swift Apus apus , hoopoe Upupa epops , swallow Hirundo rustica , house martin Delichon urbica and nightingale Luscinia megarhynchos ), in a western Mediterranean area since from 1952 to 2003. By means of multiple regression analyses, FADs were analysed in relation to the monthly temperature and precipitation patterns of five African climatic regions south of the Sahara where species are thought to overwinter and from the European site from where FADs were collected. We obtained significant models for five species explaining 9–41% of the variation in FADs. The interpretation of the models suggests that: (1) The climate in wintering quarters, especially the precipitation, has a stronger influence on FADs than that in the species' potential European breeding grounds. (2) The accumulative effects of climate patterns prior to migration onset may be of considerable importance since those climate variables that served to summarize climate patterns 12 months prior to the onset of migration were selected by final models. (3) Temperature and precipitation in African regions are likely to affect departure decision in the species studied through their indirect effects on food availability and the build‐up of reserves for migration. Our results concerning the factors that affect the arrival times of trans‐Saharan migrants indicate that the effects of climate change are more complex than previously suggested, and that these effects might have an interacting impact on species ecology, for example by reversing ecological pressures during species' life cycles.
Activity-Based Assay of Matrix Metalloproteinase on Nonbiofouling Surfaces Using Time-of-Flight Secondary Ion Mass Spectrometry (2008)

A label-free, activity-based assay of matrix metalloproteinase (MMP) and its inhibition was demonstrated on peptide-conjugated gold nanoparticles (AuNPs) with nonbiofouling poly(oligo(ethylene glycol) methacrylate) (pOEGMA) films using time-of-flight secondary ion mass spectrometry (TOF-SIMS). Following surface-initiated atom-transfer radical polymerization of OEGMA on a Si/SiO2 substrate, the MMP activity was determined by analyzing the cleaved peptide fragments using TOF-SIMS on the peptide-conjugated AuNPs. The use of nonbiofouling pOEGMA films in conjunction with AuNPs synergistically enhanced the sensitivity of assays for MMP activity and its inhibition in human serum. The detection sensitivity of MMP-7 in serum was as low as 20 ng mL(-1) (1 pmol mL(-1)), and the half-maximal inhibitory concentration (IC50) of minocycline, which is a MMP-7 inhibitor, was estimated to be 450 nM. It is anticipated that the developed system will be broadly useful for conducting activity-based assays of serum proteases, as well as for screening of their inhibitors, with high sensitivity in a high-throughput manner.