gebhart/patrepeval huggingface dataset:
Effect of NH3 plasma treatment of gate nitride on the performance of amorphous silicon thin-film transistors (1990)

The effect of NH3 plasma treatment of the hydrogenated amorphous silicon nitride (a-SiNx:H) gate insulator on the performance of hydrogenated amorphous silicon (a-Si:H) thin-film transistors (TFTs) has been studied for different deposition conditions of the gate nitride. The TFT subthreshold slope and threshold voltage decrease with increasing rf power of gate nitride deposition. When increasing the rf power from 25 to 100 W, an increase in field-effect mobility, from 0.29 to 0.37 cm2/V s, is obtained. The NH3 plasma treatment causes a general increase in subthreshold slope and threshold voltage. It also degrades the field-effect mobility as large as 40%. However, the desirable effect of the plasma treatment is that the resulting devices have a higher stability exhibited by a 25% reduction of hysteresis width of transfer characteristics and by their higher resistance to prolonged positive gate field application. Based only on the electrical measurements, an exact model of the plasma interaction with the a-SiNx:H could not be developed. However, it is postulated that both radiation damage and nitridation/amination can occur.
Cellular growth and survival are mediated by β1 integrins in normal human breast epithelium but not in breast carcinoma (1995)

We previously established a rapid three-dimensional assay for discrimination of normal and malignant human breast epithelial cells using a laminin-rich reconstituted basement membrane. In this assay, normal epithelial cells differentiate into well-organized acinar structures whereas tumor cells fail to recapitulate this process and produce large, disordered colonies. The data suggest that breast acinar morphogenesis and differentiation is regulated by cell-extra-cellular matrix (ECM) interactions and that these interactions are altered in malignancy. Here, we investigated the role of ECM receptors (integrins) in these processes and report on the expression and function of potential laminin receptors in normal and tumorigenic breast epithelial cells. Immunocytochemical analysis showed that normal and carcinoma cells in a three-dimensional substratum express profiles of integrins similar to normal and malignant breast tissues in situ. Normal cells express alpha 1, alpha 2, alpha 3, alpha 6, beta 1 and beta 4 integrin subunits, whereas breast carcinoma cells show variable losses, disordered expression, or downregulation of these subunits. Function-blocking experiments using inhibitory anti-integrin subunit antibodies showed a > 5-fold inhibition of the formation of acinar structures by normal cells in the presence of either anti-beta 1 or anti-alpha 3 antibodies, whereas anti-alpha 2 or -alpha 6 had little or no effect. In experiments where collagen type I gels were used instead of basement membrane, acinar morphogenesis was blocked by anti-beta 1 and -alpha 2 antibodies but not by anti-alpha 3. These data suggest a specificity of integrin utilization dependent on the ECM ligands encountered by the cell. The interruption of normal acinar morphogenesis by anti-integrin antibodies was associated with an inhibition of cell growth and induction of apoptosis. Function-blocking antibodies had no inhibitory effect on the rate of tumor cell growth, survival or capacity to form colonies. Thus under our culture conditions breast acinar formation is at least a two-step process involving beta 1-integrin-dependent cellular growth followed by polarization of the cells into organized structures. The regulation of this pathway appears to be impaired or lost in the tumor cells, suggesting that tumor colony formation occurs by independent mechanisms and that loss of proper integrin-mediated cell-ECM interaction may be critical to breast tumor formation.
A New Synthesis of Primary Amines Using<i>tert</i>-Butylamine as an Ammonia Equivalent: The Triflic Acid Catalysed Removal of<i>N</i>-<i>tert</i>-Butyl Groups from Carbamates (1990)

The interaction of 1 mol% of triflic acid (trifluoromethanesulfonic acid) with a range of N-substituted N-tert butylcarbamates in acetonitrile results in the removal of the tert-butyl group to give carbamate-protected primary amines in high yield. The stereochemistry α to a ketone carbonyl function is unaffected.
Incidência de choques e qualidade de vida em jovens com cardioversor-desfibrilador implantável (2007)

Despite the efficacy of ICD therapies, the high incidence of appropriate and inappropriate shocks interfered in patients QoL and adaptation to the device.
Expression of chemokine receptors on circulating tumor cells in patients with solid tumors (2012)

CR were expressed on CTC of patients with solid tumors. Along with our findings, the observation that CR could be involved in CTC proliferation and migration of tumor cells appoints CTC as potential CR-antagonist therapeutic target.
Evaluation of the Role of Microbial Strecker-Derived Aroma Compounds in Unclean-Type Flavors of Cheddar Cheese (1985)

Commercial Cheddar cheeses selected to include a variety of flavors, ages, and compositional factors were analyzed by gas chromatographic procedures for several microbially derived Strecker-type volatile aldehydes and alcohols. Six of 26 samples lacked unclean-type flavors and each contained concentrations below threshold of the Strecker-type compounds measured. All of the remaining samples exhibited some degree of uncleantype flavors and each contained concentrations above threshold of at least one of the Strecker-type compounds. When evaluated individually in a bland Cheddar cheese base, phenethanol and phenylacetaldehyde both caused flavor suppressions and unclean, rose-like aftertaste flavor sensations; phenylacetaldehyde also contributed an astringent bitterness. Elevated concentrations of p-cresol caused either unclean-utensil-like, unclean-barny, or horse-blanket-like flavors while 3-methyl butanal/2-methyl butanal, 2-methyl propanal, and methional caused uncleanharsh and dulling flavor sensations in cheese. Phenol contributed sharp, clean flavor effects to cheeses, especially in well-aged Cheddars.
A Control-Theoretic Approach to Precoding for Multi-Cast Multi-Beam over Satellite (2020)

This work explores an initial step in defining a principled and control-theoretic framework for multi-beam broadband satellite systems in a novel and challenging scenario of hybrid terrestrial-satellite mobile system architectures. Advanced control-theoretic design principles for a bent-pipe satellite payload concept for forward paths will be highlighted for: i) broadcast (point-to-multi-point) downlink on forward paths; ii) tradeoffs between terrestrial mobile network congestions and data transmission rates; and iii) judicious coordination of actual data rates and resilient precoding strategies under uncertainty for achieving reliable feeder link transmission by the ground gateway. The expected results will also help reveal new insights on risk-sensitive satellite-to-user downlinks and multicast transmission in the presence of frequency reuses as well as potential congestions from primary terrestrial mobile network counterparts.
Phosphorus Recovery in Surface Runoff from Swine Lagoon Effluent by Overland Flow (1997)

Abstract A study was conducted in Alabama to determine P removal by overland flow of swine lagoon effluent on bermudagrass ( Cynodon dactylon L.‘Russell’) and annual ryegrass ( Lolium multiflorum Lam). Treatments included ammonium nitrate at 560 kg N ha −1 yr −1 , three rates of lagoon effluent which provided 560, 1120, and 2240 kg N ha −1 yr −1 and 71, 142, and 284 kg P ha −1 yr −1 , respectively, and a control. Experiments were conducted at 5 and 10% slopes on a Marvyn loamy sand (fine‐loamy, siliceous, thermic Typic Kanhapludults). The length of slope from application site to collection site was 6.1 m. Surface runoff was collected and sampled monthly for dissolved and sediment P. The results indicated that higher concentrations of P were found during the early spring and summer seasons when treatments were applied. Concentrations of dissolved P and total P exceeded critical values associated with accelerated eutrophication. No significant differences were found for sediment P concentrations on either 5 or 10% slopes for any of the three rates of P application. Phosphorus applications did not significantly affect dissolved P concentrations on the 5% slope, but there were significant treatment effects for dissolved P concentrations on the 10% slope. Slope did not significantly affect dissolved P concentration but significantly affected sediment P concentration. Total P mass losses in surface runoff were <0.6 kg P ha −1 on the 5% slope and 1.0 kg P ha −1 on the 10% slope during the research period.
Identification of Reactive Free Radicals with a New 31P-Labeled DMPO Spin Trap (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIdentification of Reactive Free Radicals with a New 31P-Labeled DMPO Spin TrapEdward G. Janzen and Yong-Kang ZhangCite this: J. Org. Chem. 1995, 60, 17, 5441–5445Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/jo00122a022https://doi.org/10.1021/jo00122a022research-articleACS PublicationsRequest reuse permissionsArticle Views309Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Use of dynamic programming for automatic synchronization of two similar speech signals (2005)

A number of applications exist in basic speech research for Dynamic Programming (DP) algorithms that can produce accurate time registration data for aligning one speech signal with a similar speech signal. In this paper, a further application for time-alignment algorithms is described, in which replacement dialogue for a film soundtrack may be automatically synchronized to reference dialogue recorded during filming. This is being carried out in a digital signal processing system that uses a DP algorithm capable of aligning utterances of indeterminate length accurately and efficiently in real-time. The main features of this system and the DP algorithm will be described.
Effective Reporting (ER) for Mobile Host-Based Security and Forensics (2007)

A mobile device's intrusion protection system (IPS) is at odds with itself: it should run as often as necessary and remain transparent to the system and the users; however, it should use as little system resources as possible to detect, report and prevent intrusions. By creating a forensics report that regularly monitors demands placed on battery current (mA) as well as correlating power and event activities, such as processes, open ports, and registry keys, a mobile host-based form of intrusion protection can be easily integrated into virtually any network intrusion detection system (IDS.) This paper outlines a novel design, test and build methodology to generate an effective security profile and an efficient bit-vector reporting format, to provide an enhancement in detecting, alerting and responding to various misuse conditions.
Uncoupling of Rat Liver Mitochondrial Oxidative Phosphorylation by the Fasciolicide Triclabendazole and Its Sulfoxide and Sulfone Metabolites (1993)

The uncoupling activity of a narrow-spectrum benzimidazole anthelmintic triclabendazole (TCZ, 6-chloro-5-[2,3-dichlorophenoxy]-2-methylthio-benzimidazole) and its 2 principal metabolites triclabendazole sulfoxide (TCZ sulfoxide, 6-chloro-5-[2,3-dichlorophenoxy]-2-methylsulfinyl-benzimidazole) and triclabendazole sulfone (TCZ sulfone, 6-chloro-5-[2,3-dichlorophenoxyl]-2methylsulfonyl- benzimidazole) has been determined using rat liver mitochondria. With glutamate or succinate as the mitchondrial substrate, and the respiratory control index (RCI) as an indicator of uncoupling activity, we found that TCZ and its 2 main metabolites were uncouplers of oxidative phosphorylation at micromolar concentrations. The rank order of in vitro activity was TCZ sulfone > TCZ sulfoxide > TCZ. Structure-activity relationship studies revealed that the electron-withdrawing power of the substituent in the 2-position was the principal determinant of mitochondrial uncoupling activity. Correlation techniques were used to assess the strength of the relationship between the ability of TCZ and its metabolites to uncouple oxidative phosphorylation and their ability to lower the electrical resistance of planar bimolecular lipid membranes. A log-log plot of RCI I50 vs. resistance effective concentration (REC I50) gave a linear fit with a correlation coefficient (r) of 0.98; an r of 0.98 indicates a high positive relationship between the ability of these fasciolicides to uncouple oxidative phosphorylation and their ability to lower electrical resistance. These findings are consistent with the view that TCZ and its sulfoxide and sulfone metabolites are lipophilic protonophoric uncouplers of rat liver mitochondrial oxidative phosphorylation.
Filing and Settlement of Patent Disputes in the Federal Court, 1995-2005 (2007)

Patent litigation is a subject which attracts constant discussion and debate. Until recently, Australian courts were perceived as 'anti patent'. Now there seems to be some concern that Australian patent litigation is slower, and more expensive, than other analogous jurisdictions. However, in general, few statistics on patent litigation have been available and most previous work on the topic has focused on the small proportion of cases which proceed to trial. Using data obtained from Federal Court records, this article presents a set of descriptive statistics relating to the filing and settlement of patent disputes in the Federal Court from 1995 to 2005. Our analysis indicates that, as in other countries, settlement rates in Australia are high, yet the average time to settlement, and judgment, is longer in Australia. However, there is some evidence that parties are in part responsible for the length of patent proceedings by requesting long delays between court events.
Activation of Human Complement System by Dextran-Coated Iron Oxide Nanoparticles Is Not Affected by Dextran/Fe Ratio, Hydroxyl Modifications, and Crosslinking (2016)

While having tremendous potential as therapeutic and imaging tools, the clinical use of engineered nanoparticles has been associated with serious safety concerns. Activation of the complement cascade and release of proinflammatory factors C3a and C5a may contribute to infusion-related reactions, whereas opsonization with C3 fragments promotes rapid recognition and clearance of nanomaterials by mononuclear phagocytes. We used dextran-coated superparamagnetic iron oxide nanoparticles (SPIO), which are potent activators of the complement system, to study the role of nanoparticle surface chemistry in inciting complement in human serum. Using complement inhibitors and measuring levels of fluid phase markers (sC5b-9, C5a and Bb), we found that the majority of human complement activation by SPIO is through the alternative pathway (AP). SPIO prepared with high dextran/iron ratio showed some complement activation via calcium-sensitive pathways, but the AP was responsible for the bulk of complement activation and amplification. Activation via the AP required properdin, the positive regulator of the alternative C3bBb convertase. Modification of sugar alcohols of dextran with alkylating, acylating, or crosslinking agents did not overcome complement activation and C3 opsonization. These data demonstrate that human complement activation is independent of dextran modification of SPIO and suggest a crucial role of the AP in immune recognition of nano-assemblies in human serum.
Electrospinning and Solution Properties of Nafion and Poly(acrylic acid) (2007)

In this study, the electrospinning performance and solution properties of Nafion and its blend with another polyelectrolyte, poly(acrylic acid) (PAA), were investigated. Attempts to electrospin pure Nafion at various polymer concentrations (5−35 wt %), solvents, neutralization, and electrospinning conditions resulted in electrospraying rather than electrospinning. However, a polymer solution blend (5 wt %) of Nafion and PAA resulted in beaded fibers at 8 wt % PAA and smooth electrospinning above 12% PAA. Fiber sizes of the blend increased from 90 to 600 nm with increasing PAA content. Dynamic light scattering on pure Nafion solutions in various solvents reveals large aggregates (i.e., dispersion) of various sizes due to polymer backbone and ionic interactions. The lack of sufficient polymer chain entanglement evidenced by low viscosity and aggregate formation in Nafion solutions prohibits fiber formation during electrospinning. The addition of PAA to Nafion modifies the ionic strength of the solvent resulting in suppressed aggregate formation, increased viscosity, and subsequently enhanced polymer chain entanglement. Coincidentally, the onset of suppressed aggregate formation in the blend solution coincides with the electrospraying−electrospinning transition (8% PAA). In addition, thermal treatment enhances water stability of the electrospun blend fibers.
Immunochemical characterization of the kringle 4 fragment of human plasminogen. (1981)

Antisera were raised in rabbits against kringle 4, one of the five homologous domains of human plasminogen, and one which contains a site that binds lysine. A double antibody radioimmunoassay was developed for kringle 4 and used for cross-reactivity studies with plasminogen, kringle 1 + 2 + 3, kringle 5 + light chain, and the plasmin-antiplasmin complex, as competitors of either 125I-kringle 4 or 125I-Lys-plasminogen for binding to anti-kringle 4 antisera. Lys- and Glu-plasminogen caused 50% inhibition of anti-kringle 4 binding to 125I-kringle 4 at ratios of 4 and 20 mol/mol (competitor/kringle 4), respectively. The plasmin-antiplasmin complex behaved similarly to Glu-plasminogen. Kringle 1 + 2 + 3 inhibited at a ratio of about greater than 1000 mol/mol. Our results suggest that most of the surface antigenic sites of kringle 4 are exposed on Lys-plasminogen, Glu-plasminogen, and the plasmin-antiplasmin complex. There may be weak antigenic homology between kringle 4 and kringle 1 + 2 + 3, but there is little or no homology with kringle 5 + light chain and prothrombin fragments 1 and 2. Both 6-aminohexanoic acid and trans-4-(aminomethyl)cyclohexanecarboxylic acid can cause a maximum of 30% inhibition, with the latter being a much better inhibitor. Our results suggest that part of the antibody population is directed against a region of kringle 4 containing a lysine-binding site.
Identification of peptide motif that binds to the surface of zirconia (2011)

A zirconia-binding peptide motif was identified using a peptide phage display system. Yttria stabilized zirconia beads and discs were used as the target. Quartz crystal microbalance was used to monitor the binding of phages to zirconia. Starting from a library of phages displaying random sequences of 12-mer peptides, we repeated cycles of biopanning against zirconia beads. After four cycles of biopanning, we isolated a phage clone Φ#17. DNA sequencing of the corresponding portion of Φ#17 unexpectedly revealed that it displayed a 58-mer peptide (amino acid sequence: WMPSDVDINDPQGGGSRPNLHQPKPAAEAASKKKSENRKVPFYSHSWY-SSMSEDKRGW). We found that Φ#17 had a 300-fold, significantly higher binding affinity for zirconia discs than phages displaying no peptide. In quartz crystal microbalance assay, a rapid increase in energy dissipation was observed from Φ#17 but not from the control phages, indicating that Φ#17 binds to the surface of zirconia via its displayed peptide. We successfully identified a peptide motif that binds zirconia.
CCCLXXV.—The metallic compounds of certain monoximes and the structure of the oximes (1926)

T. W. J. Taylor and E. K. Ewbank, J. Chem. Soc., 1926, 129, 2818 DOI: 10.1039/JR9262902818
Secretin (2014)

This review describes the history of secretin discovery, identification, purification, and structural determination; cloning of secretin and its receptor; synthetic secretin; and highly specific and sensitive radioimmunoassay to define the characteristic physiological role on postprandial pancreatic fluid and bicarbonate secretion, which requires robust potentiation by cholecystokinin. Secretin plays a key role in the negative and positive regulatory mechanisms of exocrine pancreatic secretion. Secretin-releasing peptides were discovered in duodenal acid perfusates of both rat and dog and in canine pancreatic juice. The release and action of secretin and secretin-releasing peptides are in part mediated via vagovagal reflex mechanism involving afferent sensory neurons in proximal intestine and efferent cholinergic neurons in the pancreas. Besides acetylcholine, many neurotransmitters or neuromodulators influence release and action of secretin. The action of secretin in the pancreas depends on insulin, which also suppresses local release of somatostatin and pancreatic polypeptide. Thus, release and action of secretin are mediated via neurohormonal interaction. Clinical conditions with hypersecretinemia and hyposecretinemia are discussed. Synthetic human secretin is used for studies of exocrine pancreatic secretion, secretin-enhanced magnetic resonance cholangiopancreatography combined with exocrine pancreatic function test and diagnosis of gastrinoma syndrome. Therapeutic use of secretin is considered for the relief of severe pain in chronic pancreatitis.
Properties of ZrO[sub 2] Passive Film Formed onto Zr Electrode in 1 M NaOH at Low Voltage (2008)

In this paper, results of the potentiodynamic–potentiostatic formation of a homogeneous, passive film of on a Zr electrode in a 1 M NaOH solution at potentials lower than 4.0 V vs saturated calomel electrode are presented. The properties of such a film were investigated by electrochemical impedance spectroscopy (EIS) measurements. After fitting the EIS results by an appropriate equivalent circuit, the capacitance and resistance , as well as the space charge capacitance and space charge resistance of this film, were determined. The film was found to become an insulator (IN) at the potentials equal to and/or more positive than 2.0 V. In the potential range , a transition from a semiconducting to insulating behavior (SC-IN) has been recorded. The donor densities , as well as their flatband potentials and their space charge layer thickness, were determined from the corresponding Mott–Schottky plots recorded in two potential ranges and , where the film behaved as an n-type semiconductor. From the potential range of the insulating behavior of the film (IN), its thickness was determined from .