gebhart/patrepeval huggingface dataset:
Exercise and Weight Control (1993)

Several important questions need to be answered to increase the likelihood that exercise will be accepted by the millions in the population who are obese. What is the minimum exercise "dose" (intensity, duration, frequency) and what is the optimal mode to bring about substantial fat weight loss, with minimal loss of lean mass? What is the best nutritional plan to optimize fat utilization during exercise, without impairing performance or loss of lean mass? Which diet and exercise programs maximally increase utilization of centrally deposited fat and how can hyperplastic obesity best be treated? Also of interest is the potential role of resistance exercise for weight loss, and the predictors of weight loss success. For instance, do individuals with gynoid obesity really differ from individuals with android obesity in their utilization and loss of body fat during exercise? The potential advantages of exercise include: stimulation of fat as opposed to carbohydrate oxidation; increased energy use during the exercise itself and in the postexercise period; protection of lean body mass; possible reversal of the diet-induced suppression of BMR; and other health benefits. Among other parameters, the effectiveness of exercise on weight loss may be influenced by the type, intensity, frequency, and duration of exercise bouts and the duration of the training program, the nature of the excess fat stores, i.e., whether the person has obesity characterized by hyperplastic or hypertrophic adipose tissue or central (with large-intra-abdominal depot) or peripheral obesity, the composition and caloric content of the diet, and behavioral aspects that affect adherence to the program. With respect to this latter concern, even if a person has been very successful at weight loss in a metabolic ward or intensive program, he/she must eventually return to the outside world and figure out for himself/herself how to eat real food and/or maintain an activity level that promotes weight maintenance. Because diet and exercise habits are difficult to assess and to quantify in free-living populations, it continues to be difficult to evaluate the success of diet and/or exercise prescriptions for weight loss accurately and we continue to be plagued with questions regarding the effectiveness vs. efficacy of exercise as a means to control body weight. It would seem that the wide range of health benefits derived from regular exercise would justify emphasizing increased activity for inactive people, particularly for obese, sedentary individuals, whether or not ideal body weight or significant weight loss is achieved.
Toluene diisocyanate protein adducts in the bronchoalveolar lavage of guinea pigs exposed to vapors of the chemical (1993)

To investigate the process of toluene diisocyanate (TDI) sensitization, studies were conducted to identify TDI-protein adducts in the bronchoalveolar lavage (BAL) fluid of guinea pigs exposed to a sensitizing atmosphere of the commercially used 4:1 mixture of 2,4- and 2,6-TDI. Animals were exposed to 2 ppm TDI for 3 h. Immediately thereafter lungs were lavaged. TDI-modified proteins in the lavage fluid were identified by immunologic staining with a highly sensitive and specific rabbit antiserum raised to a TDI-keyhole limpet hemocyanin (TDI-KLH) conjugate. The sensitivity of the antiserum was demonstrated by its ability to identify TDI-guinea pig serum albumin (GSA) adducts with as few as 0.7 mol of TDI/mol of protein. The antiserum did not react with GSA nor with a GSA adducted with another aromatic diisocyanate, diphenylmethane 4,4'-diisocyanate. TDI-protein adducts in the BAL fluid were identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by immunoblotting with use of the rabbit anti TDI-KLH antiserum. At least 5 protein bands were recognized by the antiserum. Electrophoretic mobilities indicated molecular sizes equivalent to 10.5, 38, 45, 66, and 148 kDa. Employing a murine anti-GSA antibody in immunoaffinity chromatography, one of the proteins in the 66-kDa band was identified as serum albumin. Attempts to purify the TDI-albumin adduct using a Cibacron-Sepharose column were unsuccessful. Studies with a model TDI0.7-GSA conjugate (which contained an average of 0.7 mol of TDI/mol of GSA) indicated that the TDI-albumin was not retained by the triazine dye column unless the adducted protein was first reduced by incubation with mercaptoethanol.(ABSTRACT TRUNCATED AT 250 WORDS)
Flip-chip flex-circuit packaging for power electronics (2002)

The development of high-density packaging for power electronics applications has been driven by the requirement for system functionality enhancement and cost reduction. In this paper we explore a novel power packaging concept, the flip-chip flex-circuit package, that eliminates bond wires and exhibits potential for high-level component integration with an established flex-circuit technology. A baseline power electronic module involving a half-bridge circuit has been fabricated and evaluated electrically.
Gain-Scheduled Complementary Filter Design for a MEMS Based Attitude and Heading Reference System (2011)

This paper describes a robust and simple algorithm for an attitude and heading reference system (AHRS) based on low-cost MEMS inertial and magnetic sensors. The proposed approach relies on a gain-scheduled complementary filter, augmented by an acceleration-based switching architecture to yield robust performance, even when the vehicle is subject to strong accelerations. Experimental results are provided for a road captive test during which the vehicle dynamics are in high-acceleration mode and the performance of the proposed filter is evaluated against the output from a conventional linear complementary filter.
Microscopy Image Browser: A Platform for Segmentation and Analysis of Multidimensional Datasets (2016)

Understanding the structure-function relationship of cells and organelles in their natural context requires multidimensional imaging. As techniques for multimodal 3-D imaging have become more accessible, effective processing, visualization, and analysis of large datasets are posing a bottleneck for the workflow. Here, we present a new software package for high-performance segmentation and image processing of multidimensional datasets that improves and facilitates the full utilization and quantitative analysis of acquired data, which is freely available from a dedicated website. The open-source environment enables modification and insertion of new plug-ins to customize the program for specific needs. We provide practical examples of program features used for processing, segmentation and analysis of light and electron microscopy datasets, and detailed tutorials to enable users to rapidly and thoroughly learn how to use the program.
Alicaforsen. Isis Pharmaceuticals. (2001)

Alicaforsen (ISIS-2302) is an RNase H-dependent antisense inhibitor of the intercellular adhesion molecule ICAM-1 under development by Isis Pharmaceuticals, for the potential treatment of a variety of inflammatory disorders [175741]. As of April 1997 it was in phase III trials for Crohn's disease (CD); however, the trial failed and, in December 1999, the company suspended development for this indication [352801]. In October 2000, the company re-initiated development in CD [384820] and new phase III trials had begin by May 2001 [409704]. In August 2000, phase II studies of alicaforsen in an enema formulation for ulcerative colitis and a topical formulation for psoriasis were ongoing [378715]. Development of the compound for the potential treatment of rheumatoid arthritis (RA) was discontinued in 1999 [347579]. By the end of 1998, alicaforsen was in phase II trials for kidney transplant rejection. At this time, these trials were expected to finish in mid-1999 [343460]. However, they were ongoing in September 1999, although no further development has been reported for this indication since that time [338672]. In February 1995, Isis Pharmaceuticals and Boehringer Ingelheim (BI) signed a collaborative agreement on cell adhesion inhibitors, including alicaforsen [174111]. By early 1999, Isis and BI were to decide on the next developmental step for alicaforsen following further analyses of its performance against CD [292915], [315439]. Their joint development agreement was terminated in 1999; Isis regained rights to the product and by September 1999 was in talks to license alicaforsen to another partner for CD [338672]. In June 2000, Cytogenix entered into a sponsored research agreement with Baylor College of Medicine at the Texas Medical Center Houston for the use of its ssDNA expression system for the development of antisense strategies directed against intercellular adhesion molecules for the purpose of reducing lung inflammation and injury in disease states and conditions [369677]. US-05514788, and other patents, cover antisense cell adhesion molecule inhibitors [212289], [234792].
Global zoom/pan estimation and compensation for video compression (1991)

An algorithm is presented for estimating and compensating camera zooms and pans. It models the global motion in each frame with just two parameters: a zoom factor and a two-dimensional pan vector both based on local displacement vectors found by conventional means (such as block matching). Since motion by objects in the scene obscures global motion, the algorithm can iterate to refine its estimate. Simulations suggest the algorithm is robust and accurate, and can significantly reduce both the energy of the motion compensated residual image as well as the zeroth-order entropy of the local displacement vector field.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Robust DCT Based Channel Estimation for MIMO-OFDM System (2009)

This paper deals with a novel transform domain channel estimation (TD-CE) based on discrete cosine transform (DCT) for the MIMO-OFDM system when null carriers are placed at the edges of the spectrum. After the description of the conventional DCT based method, an improved channel estimation scheme using truncated singular value decomposition is proposed. Finally the efficiency of this estimator is evaluated within 3GPP/LTE system context.
Modeling Gas-Condensate Well Deliverability (1996)

Summary This paper gives an accurate method for modeling the deliverability of gas-condensate wells. Well deliverability is calculated with a modified form of the Evinger-Muskat1 pseudopressure (originally proposed for solution-gas-drive oil wells). The producing gas/oil ratio (GOR) is needed to calculate pseudopressure, together with pressure/volume/temperature (PVT) properties (black-oil or compositional), and gas/oil relative permeabilities. The proposed method is successfully tested for radial, vertically fractured, and horizontal wells. Using the proposed deliverability model, we show that fine-grid single-well simulations can be reproduced almost exactly with a simple rate equation that uses pseudopressure. The key is knowing the producing GOR accurately. The effect of near-wellbore damage, vertical fracture, or flow improvement caused by horizontal well trajectory is readily incorporated into the rate equation as a constant skin term. The effect of gas/oil relative permeability is studied. We show that well deliverability impairment resulting from near-wellbore condensate "blockage" is dependent only on relative permeabilities within the range defined by 1 &lt;krg/kro &lt; 50. Usually this represents gas and oil relative permeabilities ranging from 0.05 to 0.3. Gas relative permeabilities at low oil saturations (krg &gt; 0.3) affect deliverability only for richer gas condensates. A key observation and conclusion from this study is that critical oil saturation has no direct effect on well deliverability. We also show that interfacial tension (IFT) dependence of relative permeability has little or no effect on gas-condensate well performance (e.g., length of plateau production). The most important application of this study is to provide a simple method for calculating bottom-hole flowing pressure (BHFP) in coarse-grid models. We show that the proposed pseudopressure method is readily calculated for each well grid cell on the basis of only grid-cell pressure and saturation (i.e., producing GOR). Local grid refinement near wells is not necessary, and relatively large well grid cells can be used and still provide an accurate description of well deliverability.
Growth window and possible mechanism of millimeter-thick single-walled carbon nanotube forests (2007)

Our group recently reproduced the water-assisted growth method, so-called "super growth", of millimeter-thick single-walled carbon nanotube (SWNT) forests by using C2H4/ H2/ H2O/ Ar reactant gas and Fe/ Al2O3 catalyst. In this current work, a parametric study was carried out on both reaction and catalyst conditions. Results revealed that a thin Fe catalyst layer (about 0.5 nm) yielded rapid growth of SWNTs only when supported on Al2O3, and that Al2O3 support enhanced the activity of Fe, Co, and Ni catalysts. The growth window for the rapid SWNT growth was narrow, however. Optimum amount of added H2O increased the SWNT growth rate but further addition of H2O degraded both the SWNT growth rate and quality. Addition of H2 was also essential for rapid SWNT growth, but again, further addition decreased both the SWNT growth rate and quality. Because Al2O3 catalyzes hydrocarbon reforming, Al2O3 support possibly enhances the SWNT growth rate by supplying the carbon source to the catalyst nanoparticles. The origin of the narrow window for rapid SWNT growth will also be discussed.
Chromatographic Removal of Endotoxins: A Bioprocess Engineer's Perspective (2012)

Gram-negative bacteria are widely used for the production of gene-based products such as DNA vaccines and bio-drugs, where endotoxin contamination can occur at any point within the process and its removal is of great concern. In this article, we review the structures of endotoxin and the effects that it causes in vivo . The endotoxin removal strategies are also discussed in the light of the different interaction mechanisms involved between endotoxins and bioproducts particularly plasmid DNA and proteins. For most cases, endotoxin removal is favoured at a highly ionic or acidic condition. Various removal methods particularly chromatography-based techniques are covered in this article according to the relevant applications.
Chymotrypsin inhibitory conformation induced by amino acid side chain–side chain intramolecular CH/π interaction (1996)

Dipeptide amides H-D-Leu-Phe-NH-R have been found to assume a conformation induced by the CH/π interaction and to inhibit chymotrypsin strongly. A series of benzyl amide derivatives H-D-Leu-Phe-NH-[CH2]n-C6H5(n= 0–4) have been assayed for chymotrypsin. They inhibit the enzyme in a competitive manner and the highest inhibition is achieved by the amide of n= 1 (Ki= 3.6 × 10–6M). The activity enhancement is dependent upon the length of methylene chain, not upon the increase in molecular hydrophobicity, indicating the presence of an optimal distance between dipeptide backbone and C-terminal phenyl group for chymotrypsin inhibition. The C-terminal phenyl group has been found to interact with chymotrypsin stereospecifically. The R-isomer of H-D-Leu-Phe-NH-CH(CH3)-C6H5 is as active as the benzyl amide, while the S-isomer is about twenty-fold less active. When the fluorine atom is introduced at a para-position of the C-terminal phenyl group, the resulting dipeptide H-D-Leu-Phe-NH-CH2-C6H4F-p exhibits about six-times increased inhibitory activity (Ki= 6.1 × 10–7M; this dipeptide is one of the most potent chymotrypsin inhibitors to date). 1H NMR conformational analyses of these dipeptide amide derivatives show the CH/π interaction between D-Leu-isobutyl and Phe-phenyl as a key structural element for chymotrypsin inhibition. These structural examinations strongly suggest that in the inhibitory conformation the C-terminal phenyl group fits the chymotrypsin S1 site, while the hydrophobic core constructed by D-Leu-Phe CH/π interaction fits the chymotrypsin S2 or S1′ site.
Intraoperative Testing of the Implantable Cardioverter‐Defibrillator: How Much Is Enough? (2005)

In this select patient cohort, success of ICD therapies and sudden-death-free survival were similar in patients who had DFT, safety margin testing, and no testing, but overall survival was significantly lower in the no-testing group. Thus in the absence of prospective mortality data, a minimum of safety margin ICD testing should remain standard practice.
Content Based Image Retrieval based on Wavelet Transform coefficients distribution (2007)

In this paper we propose a content based image retrieval method for diagnosis aid in medical fields. We characterize images without extracting significant features by using distribution of coefficients obtained by building signatures from the distribution of wavelet transform. The research is carried out by computing signature distances between the query and database images. Several signatures are proposed; they use a model of wavelet coefficient distribution. To enhance results, a weighted distance between signatures is used and an adapted wavelet base is proposed. Retrieval efficiency is given for different databases including a diabetic retinopathy, a mammography and a face database. Results are promising: the retrieval efficiency is higher than 95% for some cases using an optimization process.
Supported Catalysts in Hazardous Waste Treatment (1990)

Inorganic pollutants in wastewater can be oxidatively destroyed with hydrogen peroxide using a supported metal catalyst system. Laboratory work has demonstrated the effectiveness of these heterogeneous catalysts in oxidizing reduced sulfur compounds (e.g., sulfide, thiosulfate) more rapidly and with better efficiency than conventional homogeneously catalyzed processes. These catalysts are also effective for oxidizing and detoxifying mercaptans and cyanide in wastewater. Metals and supports studied include transition metals on silica, alumina, and various natural and synthetic zeolites. The choice of metal and support varies with the pollutant. A significant advantage of heterogeneous catalysts is that they are not subject to the pH limitations often found with soluble catalysts, working equally well in acid and alkaline conditions. Further, they can be used in treating continuously flowing wastewater streams without the need for continuous addition of metal salts. This eliminates the possibility of secondary pollution problems due to the added metal and reduces cost. The potential for using this catalyst concept for treating a wider variety of toxic pollutants will be discussed.
Gain maximization and controlled null placement simultaneously achieved in aerial array patterns (1970)

This paper presents a matrix method for maximizing aerial directive gain, while simultaneously placing nulls in the far-field radiation pattern of the array. The technique is applicable to aerial arrays of N elements, arbitrarily positioned, and allows the designer to specify the directions of up to (N—1) independent pattern nulls and/or side-lobes, while providing maximum gain in some prespecified direction. This control is achieved by varying only the amplitude and phase of the element currents. The method can be used even when non-isotropic aerial elements and interelement mutual coupling effects are included in the expression for directive gain.
Elasticity of an interfacial particle raft (2004)

We study the collective behaviour of a close packed monolayer of non-Brownian particles at a fluid-liquid interface. Such a particle raft forms a two-dimensional elastic solid and can support anisotropic stresses and strains, e.g. it buckles in uniaxial compression and cracks in tension. We characterise this solid in terms of a Young's modulus and Poisson ratio derived from simple theoretical considerations and show the validity of these estimates by using an experimental buckling assay to deduce the Young's modulus.
10G-EPON: Drivers, challenges, and solutions (2009)

Responding to market demand for increased access capacity, the IEEE 802.3av has standardized 10G-EPON. The new specification has successfully resolved a number of technical challenges, including the coexistence with the mass-deployed 1G-EPON, resulting in a highly efficient architecture.
Multiflash Stereopsis: Depth-Edge-Preserving Stereo with Small Baseline Illumination (2007)

Traditional stereo matching algorithms are limited in their ability to produce accurate results near depth discontinuities, due to partial occlusions and violation of smoothness constraints. In this paper, we use small baseline multi-flash illumination to produce a rich set of feature maps that enable acquisition of discontinuity preserving point correspondences. First, from a single multi-flash camera, we formulate a qualitative depth map using a gradient domain method that encodes object relative distances. Then, in a multiview setup, we exploit shadows created by light sources to compute an occlusion map. Finally, we demonstrate the usefulness of these feature maps by incorporating them into two different dense stereo correspondence algorithms, the first based on local search and the second based on belief propagation. Experimental results show that our enhanced stereo algorithms are able to extract high quality, discontinuity preserving correspondence maps from scenes that are extremely challenging for conventional stereo methods. We also demonstrate that small baseline illumination can be useful to handle specular reflections in stereo imagery. Different from most existing active illumination techniques, our method is simple, inexpensive, compact, and requires no calibration of light sources.
Characterization of the susceptibility of Pseudomonas aeruginosa to complement-mediated killing: role of antibodies to the rough lipopolysaccharide on serum-sensitive strains (1988)

The mechanism of complement-mediated killing of seven serum-sensitive Pseudomonas aeruginosa strains was examined. All seven strains were sensitive to the bactericidal activity of 20% pooled normal human serum (PNHS) containing magnesium EGTA, which blocks the classical complement pathway (CCP), or 20% PNHS preheated to 50 degrees C for 20 min, which inactivates the alternative complement pathway, suggesting that either pathway was effective against these strains. However, for four of these strains, optimal killing required the function of both pathways. Preabsorption of PNHS with serum-sensitive strains dramatically reduced the killing activity of serum for the homologous strains when a concentration of 10% serum was used, implying a role for antibody in the activation of complement via the CCP. Affinity purification of antibodies to the rough lipopolysaccharide (LPS) on strain 144M resulted in a pool of antibodies which could restore all of the bactericidal activity and most of the C3 activation-deposition activity of serum which had been lost by preabsorption with 144M. Confirmation that the LPS was the target for these bactericidal antibodies was provided by demonstrating that exogenously added 144M LPS inhibited the killing activity of PNHS. These anti-144M LPS-specific antibodies were also bactericidal for the six other serum-sensitive strains examined, suggesting that all seven strains shared an antigenic determinant recognized by these anti-144M LPS-specific antibodies. Results from cross-absorption studies imply that there are bactericidal antibodies in PNHS directed to additional bacterial targets. These studies suggest that part of the bactericidal activity of PNHS is due to binding of antibodies to the rough LPS on serum-sensitive strains, initiating activation of the CCP, and that all seven strains examined shared this bactericidal antibody-binding site.