gebhart/patrepeval huggingface dataset:
Business component identification - a formal approach (2002)

Component based software development is carried out in two phases: component building and application assembly. The key to building business components is a formal approach for identifying the components. The paper describes such an approach, which assists in identifying the components from an Analysis Level Object Model, representing a business domain. The approach makes use of a clustering algorithm, certain constraints, a predefined rule and a set of heuristics. The approach has been implemented in a tool named 'CompMaker' and was used for identifying components for an auto insurance claims domain.
<i>MECP2</i> mutation in male patients with non‐specific X‐linked mental retardation (2000)

In contrast to the preponderance of affected males in families with X-linked mental retardation, Rett syndrome (RTT) is a neurological disorder occurring almost exclusively in females. The near complete absence of affected males in RTT families has been explained by the lethal effect of an X-linked gene mutation in hemizygous affected males. We report here on a novel mutation (A140V) in the MECP2 gene detected in one female with mild mental retardation. In a family study, the A140V mutation was found to segregate in the affected daughter and in four adult sons with severe mental retardation. These results indicate that MECP2 mutations are not necessarily lethal in males and that they can be causative of non-specific X-linked mental retardation.
Dihydroergotamine: discrepancy between arterial, arteriolar and pharmacokinetic data (2001)

DHE decreased diameter and compliance of the brachial artery whereas forearm vascular resistance remained unchanged. Thus, DHE acts on conduit arteries without affecting resistance arteries. Furthermore, a discrepancy was demonstrated between the plasma concentrations of DHE which rapidly reach peak levels and quickly decline, and its long lasting vasoconstrictor activity.
The Role of Nitrogen on Charge-Trapping-Induced $V_{\rm th}$ Instability in HfAlON High-$\kappa$ Gate Dielectric With Metal and Poly-Si Gate Electrodes (2007)

The impact of N on HfAlON dielectrics has been extensively studied in devices with TaN metal and poly-Si gate electrodes. A similar trend of the N effects was observed in both TaN and poly-Si devices in terms of equivalent oxide thickness, gate leakage current, threshold voltage ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> ), transconductance, and subthreshold swing. However, compared to the HfAlON with TaN metal gate, a severe <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> instability induced by charge trapping was generally observed in the poly-Si/HfAlON devices. In addition, the incorporation of N in the HfAlON films was found to play an opposite role in the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> instability between the TaN and poly-Si devices: In the TaN metal gate devices, the charge-trapping-induced <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> instability in the HfAlON was slightly degraded by increasing the N concentration, whereas the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> instability was remarkably improved by increasing the N concentration in the poly-Si gate devices. The degradation of the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> instability observed in the TaN metal gate devices is believed to be due to the increase in preexisting bulk traps that is caused by incorporating N into the gate dielectric. The significant improvement on the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> instability in the devices with poly-Si gate could be mainly attributed to the remarkable suppression of electron trapping at oxygen vacancies by adding N into the high- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> gate dielectric.
Absolute Quantitation of Met Using Mass Spectrometry for Clinical Application: Assay Precision, Stability, and Correlation with MET Gene Amplification in FFPE Tumor Tissue (2014)

The Met SRM assay measured the absolute Met levels in clinical tissues with high precision. Compared to IHC, SRM provided a quantitative and linear measurement of Met expression, reliably distinguishing between non-amplified and amplified MET tumors. These results demonstrate a novel clinical tool for efficient tumor expression profiling, potentially leading to better informed therapeutic decisions for patients with GEC.
[Unexpected anti-inflammatory activity of rigid structures derived from antihypertensive 6-arylpyridazinones. III. Synthesis and activity of 7-fluoro- and 5-keto-5H-indeno(1,2-c)pyridozines]. (1982)

5H-Indeno[1,2-c]pyridazine (Ia) and its 3-oxo- and 4,4a-dihydro-3-oxo derivatives, already known to have antiinflammatory activity, were subjected to 7-fluoro substitution or to oxidation of the 5-methylene to a carbonyl group. The pharmacological evaluation of the resulting compounds indicated that the antiinflammatory activity disappeared in the fluoro derivatives, while it was still present in the 5-keto derivatives (I e), (II c). Moreover, the analgesic-antipyretic component of (I e) proved to be strongly enhanced compared with that of (I a).
Maturation of ovarian follicles in the prepubertal gilt. (1985)

The processes of follicle development and puberty are closely related, and both are associated with maturation of the hypothalamic-pituitary-ovarian axis. Prenatal development of the ovary is independent of gonadotrophic stimulation. Beyond 60 days of age (postnatally), tertiary follicles develop and gonadotrophins begin to influence ovarian follicular development. Negative feedback regulation of pituitary gonadotrophins by ovarian secretions develops between 60 and 100 days of age. In the prepubertal gilt, no consistent changes in peripheral FSH, oestrogen or progesterone concentrations have been identified which are associated with recruitment of the first set of preovulatory follicles. Whether LH secretion increases before this recruitment remains equivocal. Few details are available on how gonadotrophic hormones stimulate ovarian function in the prepubertal gilt. On the basis of a follicular maturation model that has been described for the rat, the actions of FSH, LH and oestrogens on follicular cell receptors and the regulation of aromatase activity seem paramount. Aromatization of androgens to oestrogens has been proposed as a central regulator for follicular maturation. In the prepubertal gilt, a selective increase in peripheral FSH concentration occurs on Day 1 after unilateral ovariectomy, followed by significant increases in ovarian venous concentrations of oestradiol and inhibin on Days 2 and 4 and compensatory growth as measured by follicular fluid volume on Days 2, 4 and 8. Administration of pig follicular fluid to the prepubertal gilt during and after unilateral ovariectomy suppresses compensatory ovarian hypertrophy by mechanisms yet to be determined. In pigs a number of intraovarian factors have been identified, but there is little information on how these factors regulate follicular recruitment and growth. The factor(s) that prevents ovarian follicles in the prepubertal gilt from progressing to ovulation after acquiring the ability to ovulate in response to exogenous gonadotrophins remains unknown.
Moving Obstacles Extraction with Stereo Global Motion Model (2006)

Extraction of moving obstacles from a moving observer is vital for many ITS applications like forward vehicle collision mitigation (FYCM) and adaptive cruise control (ACC) systems. Single camera based global motion model (GMM) like optical flow is commonly used in the past decade. This paper addresses a relatively new problem in the literature: GMM based on binocular stereovision which involves the depth (disparity) information in the model, thus global motion can be analyzed in 3D space rather than the traditional 2D image plane. An efficient algorithm is presented which parameterizes the GMM based on the 3D camera motion analysis within U-V-disparity domain. Combining the geometric and motion information, regions that do not match the GMM will be extracted as moving obstacles
A MICS Band Wireless Body Sensor Network (2007)

This paper presents a MICS (medical implant communication service) based body sensor network design and implementation for patient physiological data collection for health monitoring purposes. The MICS band offers the advantage of miniaturized electronic devices that can either be used as an implanted node or as an external node. In this work, a prototype sensor network is implemented by incorporating temperature and pulse rate sensors on nodes. Each developed sensor node has the capability of physiological data acquisition and local processing. The sensor node can also transmit data over the air to a remote central control unit (CCU) for further processing and storage. The developed system offers medical staff to obtain patient's physiological data on demand basis via the Internet. Moreover, the system has been optimized for power consumption by using a polling architecture. Some preliminary performance data is presented in the paper.
Multiple-frequency continuous wave ultrasonic system for accurate distance measurement (1999)

A highly accurate multiple-frequency continuous wave ultrasonic range-measuring system for use in air is described. The proposed system uses a method heretofore applied to radio frequency distance measurement but not to air-based ultrasonic systems. The method presented here is based upon the comparative phase shifts generated by three continuous ultrasonic waves of different but closely spaced frequencies. In the test embodiment to confirm concept feasibility, two low cost 40 kHz ultrasonic transducers are set face to face and used to transmit and receive ultrasound. Individual frequencies are transmitted serially, each generating its own phase shift. For any given frequency, the transmitter/receiver distance modulates the phase shift between the transmitted and received signals. Comparison of the phase shifts allows a highly accurate evaluation of target distance. A single-chip microcomputer-based multiple-frequency continuous wave generator and phase detector was designed to record and compute the phase shift information and the resulting distance, which is then sent to either a LCD or a PC. The PC is necessary only for calibration of the system, which can be run independently after calibration. Experiments were conducted to test the performance of the whole system. Experimentally, ranging accuracy was found to be within ±0.05 mm, with a range of over 1.5 m. The main advantages of this ultrasonic range measurement system are high resolution, low cost, narrow bandwidth requirements, and ease of implementation.
Identification of Extract Method Refactoring Opportunities (2009)

Extract method has been recognized as one of the most important refactorings, since it decomposes large methods and can be used in combination with other refactorings for fixing a variety of design problems. However, existing tools and methodologies support extraction of methods based on a set of statements selected by the user in the original method. The goal of the proposed methodology is to automatically identify extract method refactoring opportunities and present them as suggestions to the designer of an object-oriented system. The suggested refactorings adhere to three principles: the extracted code should contain the complete computation of a given variable declared in the original method, the behavior of the program should be preserved after the application of the refactoring, and the extracted code should not be excessively duplicated in the original method. The proposed approach is based on the union of static slices that result from the application of a block-based slicing technique. The soundness of the identified refactoring opportunities has been evaluated by an independent designer on the system that he developed.
Minimal cost availability improvement of fixed mobile convergent (FMC) access networks: Diversification and redundancy (2015)

Fixed Mobile Convergence is significantly changing the role of access networks: the same infrastructure will be serving fixed broadband access, mobile macro- and small cells. It brings new challenges on the architectural level, network availability being one of the key aspects. However, the strong cost pressure in the access networks makes extensive deployment of redundancy economically infeasible. The key for affordable availability improvement is the (application specific) identification of the most critical failures. In this paper we review the main application fields of FMC networks, differentiated by its clients (residential fixed customers, mobile macro- and small cells). The most critical failures are identified for each application, and metrics are presented for evaluating failure criticality and network availability. Finally, appropriate strategies will be proposed for improving the network availability under tight cost restrictions, and the cost and availability implications will be discussed. Availability improvement not necessarily requires protection resources; diversification network planning techniques also play an important role.
Crystallization and preliminary X-ray characterization of Epstein–Barr virus BHRF1 in complex with a benzoylurea peptidomimetic (2012)

BHRF1 is a pro-survival Bcl-2 homologue encoded by Epstein-Barr virus (EBV) that plays a key role in preventing premature host cell death during viral infection and may contribute to the development of malignancies associated with chronic EBV infections. The anti-apoptotic action of BHRF1 is based on its ability to sequester pro-apoptotic Bcl-2 family proteins, in particular Bim and Bak. These interactions have been previously studied in three dimensions by determining crystal structures of BHRF1 in complex with both Bim and Bak BH3 domains. Screening of a library of peptidomimetic compounds based on the benzoylurea scaffold that mimics critical Bim BH3 domain side chains against BHRF1 led to the identification of an inhibitor of BHRF1 that displays micromolar affinity. Single crystals were obtained from the co-crystallization of recombinant BHRF1 protein with this peptidomimetic compound. The crystals belonged to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a=66.8, b=91.1, c=151.9 Å. Diffraction data were collected to 2.11 Å resolution on the MX2 beamline at the Australian Synchrotron.
A review of speech-based bimodal recognition (2002)

Speech recognition and speaker recognition by machine are crucial ingredients for many important applications such as natural and flexible human-machine interfaces. Most developments in speech-based automatic recognition have relied on acoustic speech as the sole input signal, disregarding its visual counterpart. However, recognition based on acoustic speech alone can be afflicted with deficiencies that preclude its use in many real-world applications, particularly under adverse conditions. The combination of auditory and visual modalities promises higher recognition accuracy and robustness than can be obtained with a single modality. Multimodal recognition is therefore acknowledged as a vital component of the next generation of spoken language systems. The paper reviews the components of bimodal recognizers, discusses the accuracy of bimodal recognition, and highlights some outstanding research issues as well as possible application domains.
Regulation of Pulmonary and Systemic Bacterial Lipopolysaccharide Responses in Transgenic Mice Expressing Human Elafin (2003)

ABSTRACT The control of lung inflammation is of paramount importance in a variety of acute pathologies, such as pneumonia, the acute respiratory distress syndrome, and sepsis. It is becoming increasingly apparent that local innate immune responses in the lung are negatively influenced by systemic inflammation. This is thought to be due to a local deficit in cytokine responses by alveolar macrophages and neutrophils following systemic bacterial infection and the development of a septic response. Recently, using an adenovirus-based strategy which overexpresses the human elastase inhibitor elafin locally in the lung, we showed that elafin is able to prime lung innate immune responses. In this study, we generated a novel transgenic mouse strain expressing human elafin and studied its response to bacterial lipopolysaccharide (LPS) when the LPS was administered locally in the lungs and systemically. When LPS was delivered to the lungs, we found that mice expressing elafin had lower serum-to-bronchoalveolar lavage ratios of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-α), macrophage inflammatory protein 2, and monocyte chemoattractant protein 1, than wild-type mice. There was a concomitant increase in inflammatory cell influx, showing that there was potential priming of innate responses in the lungs. When LPS was given systemically, the mice expressing elafin had reduced levels of serum TNF-α compared to the levels in wild-type mice. These results indicate that elafin may have a dual function, promoting up-regulation of local lung innate immunity while simultaneously down-regulating potentially unwanted systemic inflammatory responses in the circulation.
A PRACTICAL ROUTE TO OPTICALLY ACTIVE CBI, A POTENT ANALOG OF THE CC-1065 ALKYLATION SUBUNIT (1997)

benz []indol-4-one, CBI precursor, racemic 3 was resolved by Lipase PS catalyzed hydrolysis in water-saturated isopropyl ether. A practical route for the synthesis of optically active CBI. a potent analog of the CC-1065 pharmacophore, starting from the resolved material was thereby developed.
Hippocrates: First-Do-No-Harm Detailed Placement (2007)

Physical synthesis optimizations and engineering change orders typically change the locations of cells, resize cells or add more cells to the design after global placement. Unfortunately, those changes usually lead to wirelength increases; thus another pass of optimizations to further improve wirelength, timing and routing congestion characteristics is required. Simple wirelength-driven detailed placement techniques could be useful in this scenario. While such techniques can help to reduce wirelength, ones without careful timing constraint considerations might degrade the timing characteristics (worst negative slack, total negative slack, etc) and/or introduce more electrical violations (exceeding maximum output load constraints and maximum input slew constraints). In this paper, we propose a new detailed placement paradigm, which use a set of pin-based timing and electrical constraints in detailed placement to prevent it from degrading timing or violating electrical constraints while reducing wire-length, thus dubbed as Hippocrates: FIRST-DO-NO-HARM optimizations. Our experimental results show great promises. By honoring these constraints, our detailed placement technique not only reduces total wirelength (TWL), but also significantly improves timing, achieving 37% better total negative slack (TNS).
Application of Tuned Mass Damper to Mitigation of the Seismic Responses of Electrical Equipment in Nuclear Power Plants (2020)

A tuned mass damper (TMD) was developed for mitigating the seismic responses of electrical equipment inside nuclear power plants (NPPs), in particular, the response of an electrical cabinet. A shaking table test was performed, and the frequency and damping ratio were extracted, to confirm the dynamics of the cabinet. Electrical cabinets with and without TMDs were modeled while using SAP2000 software (Version 20, Computers and Structures, NY, USA) that was based on the results. TMDs were designed while using an optimization method and the equations of Den Hartog, Warburton, and Sadek. The numerical models were verified while using the shaking table test results. A sinusoidal sweep wave was applied as input to identify the vibration characteristics of the electrical cabinet over a wide frequency range. Applying various seismic loads that were adjusted to meet the RG 1.60 design response spectrum of 0.3 g then validated the control performance of the TMD. The minimum and maximum response spectrum reduction rates of the designed TMDs were 44.7% and 62.9%, respectively. Further, the amplification factor of the electrical cabinet with the TMD was decreased by 53%, on average, with the proposed optimization method. In conclusion, TMDs can be considered to be an effective way of enhancing the seismic performance of the electrical equipment inside NPPs.
Abstract 4692: ABT-888 synergizes treatment of colon cancer cell lines with irinotecan (2012)

Abstract Numerous studies have associated poly [ADP-ribosolose] polymerase 1 (PARP1) with DNA-damage repair. PARP1 rapidly localizes to DNA damage sites where it alters target proteins, (e. g. histones, topoisomerase I and DNA dependent protein kinase (DNA-PK)), through the addition of poly-ADP ribose side chains. By this mechanism, PARP1 plays a role in diverse repair pathways including homologous recombination/non-homologous end joining (HRR/NHEJ). Presently, third generation PARP inhibitors are in use clinically. These drugs have resulted in meaningful clinical responses and an increase in survival in metastatic breast and ovarian cancer patients bearing BRCA-deficient or triple negative tumors. The Abbott lead compound, ABT-888, is a potent PARP1 inhibitor that sensitizes many cancer cells in-vitro and in-vivo to temozolomide. In the present work, we hypothesized that colon cancers would be sensitized to the DNA damaging chemotherapeutic agent, irinotecan by ABT-888. Since PARP1 is involved in DNA repair, we propose that its inhibition would increase irinotecan-induced DNA damage and cell death in colon cancer cells lines. Using the sulforhodamine B assay (SRB), significant synergy (I&lt;1 indicates synergy) was observed between ABT-888 and irinotecan at concentrations as low as 0.06 μM (Table 1). Levels of synergy observed in the SRB assay correlated with levels of PARP1 inhibition measured biochemically in cell lysates. Furthermore, 24h post treatment combinations of ABT-888/SN38 resulted in increased G2/M cell cycle arrest and increased levels of DNA damage as determined by γH2AX staining and comet assay. Additionally, 48h post treatment increased levels of apoptosis were associated with this drug combination. In conclusion this study suggests that ABT-888 may be a clinically effective adjuvant to current colon cancer therapies that include the use of irinotecan. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4692. doi:1538-7445.AM2012-4692