gebhart/patrepeval huggingface dataset:
A 10-b, 75-MHz two-stage pipelined bipolar A/D converter (1993)

A 4-b flash first quantizer is cascaded with an efficient 7-b second quantizer to attain 10-b resolution after error correction. As the second quantizer itself embodies analog subranging through folding and interpolation, its complexity is comparable with that of the first quantizer. An input track and hold preceding the first quantizer acquires dynamic signals with low distortion, and a second track and hold delays the analog residue signal to pipeline the operation of the two quantizers. This collection of components, accompanied by all necessary digital circuits for encoding and error correction is fabricated on an all-NPN 4-GHz f/sub T/ bipolar IC measuring 4*4 mm, which dissipates 800 mW from +or-5-V supplies. At a 75-MEPi conversion rate, the untrimmed ADC exhibits 59 db S/(N+D) with a 6-MHz full-scale input, which diminishes by only 3 dB when the input frequency rises to 50 MHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Pharmacotherapy of headache with special reference to migraine]. (1994)

Drug therapy is only one possibility to treat headache or migraine. In a migraine attack aspirin, acetaminophen, non-steroidal antiinflammatory drugs like ibuprofen, naproxen and mefenamic acid are used. Further more weak opiates, caffeine, metoclopramide and the new 5-HT1-receptor agonist sumatriptan are effective in the attack. Ergotamine and dihydroergotamine are probably the most effective though their side effects are troublesome. For prophylactic treatment, the beta-adrenergic receptor blockers propranolol, metoprolol and atenolol are the drugs of first choice. Also calcium channel antagonists like flunaricine and antidepressant drugs like amitryptiline and doxepine are used.
An empirical study on the effects of test type ordering on overall test efficiency (2002)

The order in which the various test types are applied can have an impact on the overall efficiency of the test operation. Furthermore, the speed at which the tests can be executed and the latency of defect detection are also important factors. In this paper, we evaluate an exhaustive set of test orderings over a variety of assumed execution parameters to analyze their effects on overall tester time consumption.
Functional Analysis of a Breast Cancer-Associated FGFR2 Single Nucleotide Polymorphism Using Zinc Finger Mediated Genome Editing (2013)

Genome wide association studies have identified single nucleotide polymorphisms (SNP) within fibroblast growth factor receptor 2 (FGFR2) as one of the highest ranking risk alleles in terms of development of breast cancer. The potential effect of these SNPs, in intron two, was postulated to be due to the differential binding of cis-regulatory elements, such as transcription factors, since all the SNPs in linkage disequilibrium were located in a regulatory DNA region. A Runx2 binding site was reported to be functional only in the minor, disease associated allele of rs2981578, resulting in increased expression of FGFR2 in cancers from patients homozygous for that allele. Moreover, the increased risk conferred by the minor FGFR2 allele associates most strongly in oestrogen receptor alpha positive (ERa) breast tumours, suggesting a potential interaction between ERa and FGFR signalling. Here, we have developed a human cell line model system to study the effect of the putative functional SNP, rs2981578, on cell behaviour. MCF7 cells, an ERa positive breast cancer cell line homozygous for the wild-type allele were edited using a Zinc Finger Nuclease approach. Unexpectedly, the acquisition of a single risk allele in MCF7 clones failed to affect proliferation or cell cycle progression. Binding of Runx2 to the risk allele was not observed. However FOXA1 binding, an important ERa partner, appeared decreased at the rs2981578 locus in the risk allele cells. Differences in allele specific expression (ASE) of FGFR2 were not observed in a panel of 72 ERa positive breast cancer samples. Thus, the apparent increased risk of developing ERa positive breast cancer seems not to be caused by rs2981578 alone. Rather, the observed increased risk of developing breast cancer might be the result of a coordinated effect of multiple SNPs forming a risk haplotype in the second intron of FGFR2.
Purification and Characterization of DNA Polymerase α-Associated Replication Protein A-Dependent Yeast DNA Helicase A (1997)

A novel, eukaryotic, hexameric DNA helicase that was earlier identified as a component of the multiprotein polymerase alpha complex [Biswas et al. (1993) Biochemistry 32, 13393-13398] has been purified to homogeneity and characterized. Thus far, our studies demonstrated that helicase A shares certain unique features of two other hexameric DNA helicases: the DnaB helicase of Escherichia coli and the T-antigen helicase of the SV40 virus. The helicase activity was stimulated by yeast replication protein A (RPA) and to a lower extent by E. coli single-stranded DNA binding protein (SSB). The helicase had an apparent molecular mass of 90 kDa, as determined by its mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A tryptic peptide fragment of the polypeptide was sequenced followed by a BLAST search of GenBank with the tryptic peptide sequence. The search identified a 1.8 kb open reading frame previously designated as ykl017c on chromosome XI, that codes for a 78.3 kDa (683 amino acid) polypeptide. The important features of the polypeptide sequence of helicase A included a type I ATP/GTP binding motif, and a K E E R R L N V A M T R P R R sequence at the C-terminus that may be indicative of a nuclear localization signal which is required of a nuclear DNA helicase. The polypeptide sequence of helicase A appears to have homology to the DnaB helicase of E. coli (approximately 25%). The facts that these two helicases are vastly separated by evolution and retained similar structural and functional features, as demonstrated here, point to a possible significance of this limited homology. Although the amount of purified helicase A was limited, we have carried out necessary enzymatic characterization so that these data could be correlated with that of immunoaffinity-purified helicase A and recombinant helicase A expressed in heterologous systems.
A Framework for Seamless Information Retrieval between an EPC Network and a Mobile RFID Network (2006)

The EPC network, a de facto standard of RFID network, provides a variety of services including Information Service (IS) and Discovery Service (DS), fully utilizing today's Internet capabilities, such as HTTP or SOAP communication protocols and HTML or XML contents formats. The mobile RFID network exploits the existing cellular network infrastructure and offers RFID-related information services to the subscribers with cellular phones which RFID reader chips are built in. However, in current cellular network environment, contents are usually represented in WML and delivered by WAP protocol, due to the limitations such as narrow network bandwidth, constraints in display resolution, processing power, and memory space for hand-held phones. Inherently, these bring the problems in information exchange between EPC network and mobile RFID network. In this paper, we investigate and suggest a framework to allow EPC network as well as mobile RFID users to seamless access the information located in the other network. Firstly, we propose an application level gateway which transforms the protocols and contents formats used in EPC network into those specially used in mobile RFID network, and vice versa. The transformation rules may be derived by name resolution at the local ONS installed in mobile RFID network. Moreover, it is suggested that the transformation rules may be automatically derived and transparently accomplished by writing well-formed pair of NAPTR resource records for the local ONS of mobile network, regardless of user's location. Finally, an module concept for RFID applications is proposed not only to lighten the workload of cellular phone equipped with RFID reader and save bandwidth, but also to accommodate the heterogeneity and evolution of cellular phone capabilities.
Reverse Transcriptase Inhibitors in HIV/AIDS Therapy (2006)

The contributors herein have carefully checked to ensure that the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time of publication. Notwithstanding, as new research, changes in government regulations, and knowledge from clinical experience relating to drug therapy and drug reactions constantly occurs, the reader is advised to check the product information provided by the manufacturer of each drug for any change in dosages or for additional warnings and contraindications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug. It is the responsibility of the treating physician to determine dosages and treatment strategies for individual patients. Further it is the responsibility of the health care provider to ascertain the Food and Drug Administration status of each drug or device used in their clinical practice. The publisher, editors, and
The susceptibility of smooth implant surfaces to periimplant fibrosis and migration of polyethylene wear debris. (1995)

The purpose of this investigation was to establish whether the tissue response and migration of polyethylene debris differed at noncemented smooth and porous implant surfaces. This was accomplished through 3 separate but closely related studies: (1) a canine cylindrical implant model with smooth and porous surfaces exposed to polyethylene debris; (2) a canine total hip arthroplasty model analyzing the interface between bone and femoral implants with various porous-coating configurations; and (3) a histologic analysis of autopsy-retrieved, human, noncemented hip prostheses with noncircumferential porous coating. The cylindrical implant model involved the placement of split cylinders, 1/2 porous and 1/2 smooth, into the distal femur and proximal tibia of 4 dogs. Four control implants and 10 test implants (chronically exposed to simulated polyethylene debris with a mean size of 4.7 microns) were examined histologically as long as 30 weeks after surgery. The canine hip study involved the study of 54 noncemented hip prostheses at periods of 1, 6, and 24 months. The prostheses possessed 4 different porous surface configurations: 1 with circumferential porous coating, 2 with noncircumferential coating, and 1 without porous coating. The human retrieval analysis involved the study of 7 cadaveric femora (age, 6 months-5 years) implanted with a straight titanium-alloy prosthesis possessing proximal pads of titanium fiber metal on the anterior, posterior, and medial aspects. With all implants in all 3 studies, there was the common finding of bone ingrowth at the porous implant surface and a fibrous interface or periprosthetic cavity around the portion of the implant that was smooth surfaced. The periprosthetic cavity typically was encapsulated by a thin continuous shell of trabecular bone. In addition, polyethylene debris was found to have preferentially migrated along the smooth implant surfaces. In the longer-term canine and human hip retrievals, polyethylene particles in the micron size range were present within histiocytes, whereas larger particles as much as 100 microns were found within foreign-body giant cells. Of importance for the implants from all 3 studies, with the exception of some pronounced cavities on the lateral aspect of the human hip prostheses, the periimplant cavities around the smooth surfaces were not detectable radiographically. This study clearly established a fundamental principle of relative barriers to particulate debris migration. Smooth implant surfaces are more susceptible than porous surfaces to the development of a fibrous tissue filled periimplant cavity and the subsequent migration of polyethylene wear debris.(ABSTRACT TRUNCATED AT 400 WORDS)
Adhesion to dentin by means of Gluma resin (1988)

In its present version, the Gluma system for bonding restorative resin to dentin involves the application of an enamel bonding agent prior to the composite resin. Conceivably, pretreating the dentin with solutions of amino acids, and incorporating camphorquinone and selected methacrylic monomers into the Gluma adhesive would nullify the need for the enamel bonding agent. A bond strength to dentin of 13.4 MPa was obtained in the control experiment. Using a solution of pyruvic acid and glycine as pretreatment, and an optimized adhesive mixture containing glutaraldehyde, HEMA, BIS-GMA, camphorquinone, and water, bond strengths to dentin of 14.5 MPa and to enamel of 23.3 MPa were obtained. Thus, the new Gluma bonding system gave acceptable bond strengths without the prior application of enamel bonding agents.
Sequence determination of nucleic acids containing 5-methylisocytosine and isoguanine: identification and insight into polymerase replication of the non-natural nucleobases (2005)

Nucleobase analogs 5-methylisocytosine ((Me)isoC) and isoguanine (isoG) form a non-natural base pair in duplex nucleic acids with base pairing specificity orthogonal to the natural nucleobase pairs. Sequencing reactions were conducted with oligodeoxyribonucleotides (ODNs) containing d(Me)isoC and disoG using modified pyrosequencing and dye terminator methods. Modified dye terminator sequencing was generally useful for the sequence identification of ODNs containing the non-natural nucleobases. The two sequencing methods were also used to monitor nucleotide incorporation and subsequent extension by Family A polymerases used in the sequencing methods with a six-nucleobase system that includes d(Me)isoC and disoG. Nucleic acids containing the six-nucleobase system could be replicated well, but not as well as natural nucleic acids, especially in regions of high d(Me)isoC-disoG content. Challenges in replication with d(Me)isoC-disoG are consistent with nucleobase tautomerism in the insertion step and disrupted minor groove nucleobase pair-polymerase contacts in subsequent extension.
Interleukin 2 acts as an adjuvant to increase the potency of inactivated rabies virus vaccine. (1989)

Interleukin 2 (IL-2) occupies a central position in the cascade of events involved in the immune response. We were interested in determining whether IL-2 could function as an adjuvant to vaccination, to increase the immune response to vaccine immunogens. Using the National Institutes of Health test for rabies vaccine potency, we found that daily systemic administration of IL-2 in conjunction with inactivated rabies virus can increase the potency of vaccination in outbred mice at least 25-fold, as measured by survival following challenge with virulent rabies virus. Enhanced protection is not correlated with an increase in virus-neutralizing antibody titers, and we suggest that IL-2 acts to increase the cellular immune response to vaccination.
Evolution of low density lipoprotein structure probed with monoclonal antibodies. (1984)

To assess the relationship of apoB structures in different species of animals, the expressions of apoB epitopes in the sera or plasmas of 23 different mammalian species and one marsupial, and on the low density lipoprotein (LDL) from three species of apes, six species of monkeys, and eight non-primates were measured in competitive radioimmunoassays. The abilities of the sera or LDL to compete with 125I-labeled human LDL for binding to seven monoclonal antihuman LDL antibodies immobilized on microtiter plates were determined. LDL of apes bound to most antibodies, while monkey LDL bound to two or three antibodies. Other mammalian LDL bound only weakly to two of the antibodies or to none. The two monoclonal antibodies binding the LDL of more species were those antibodies which also inhibited the binding to and degradation of LDL by human fibroblasts. The rank order of binding of the LDL of a given species to the antibodies correlated with the rank order inhibition of binding and degradation of 125I-labeled human LDL in the human fibroblast system. This suggests that epitopes spatially located near the recognition site of apoB for cellular receptors have a greater tendency to be conserved.
Mechanism of Action of Flavonoids as Anti-inflammatory Agents: A Review (2009)

Flavonoids are polyphenolic compounds that occur ubiquitously in plants having a variety of biological effects both in vitro and in vivo. They have been found to have antimicrobial, antiviral, anti-ulcerogenic, cytotoxic, anti-neoplastic, mutagenic, antioxidant, antihepatotoxic, antihypertensive, hypolipidemic, antiplatelet and anti-inflammatory activities. Flavonoids also have biochemical effects, which inhibit a number of enzymes such as aldose reductase, xanthine oxidase, phosphodiesterase, Ca(+2)-ATPase, lipoxygenase, cycloxygenase, etc. They also have a regulatory role on different hormones like estrogens, androgens and thyroid hormone. They have been found to have anti-inflammatory activity in both proliferative and exudative phases of inflammation. Several mechanisms of action have been proposed to explain anti-inflammatory action of flavonoids. The aim of the present review is to give an overview of the mechanism of action of potential anti-inflammatory flavonoids.
A Cost Estimation Model for Cloud Services and Applying to PC Laboratory Platforms (2020)

IaaS (Infrastructure as a Service) is a well-known computing service, which provides infrastructures over the cloud without owning real hardware resources. This is attractive as resources can be scaled up and down instantly according to the user’s computing demands. Customers of such services would like to adjust the utilization policy promptly by considering the charge of the service, but an instantaneous response is not possible as it takes several hours or even a couple of days for cloud service providers to inform the billing information. In this article, we present an instant cost estimation model for estimating the cost of public cloud resources. Specifically, our model estimates the cost of IaaS by monitoring the usage of resources on behalf of virtual machine instances. As this is performed by generating a user-side metering daemon, it is very precise and thus similar to the resource usage evaluated by the cloud service provider. To validate our model, we run PC laboratory services for 50 students in two classes by making use of a public cloud during a semester. Experimental results show that the accuracy of our model is over 99.3% in comparison with the actual charge of the public cloud.
<title>Optimization Of Short Scan Convolution Reconstruction In Fan Beam CT</title> (1982)

The problem of image reconstruction using a minimal complete set of projection measurements in conjunction with a standard divergent reconstruction algorithm is reviewed. It is shown that by optimally weighting the projection measurements, unimpaired image quality can be obtained. Boundary conditions are developed which minimize boundary discontinuities and resulting streaks in the final image. A simple application of calculus of variations is used to find a set of weights which satisfy the boundary conditions and which minimize second order changes in the weights. Image quality comparable to reconstruction from a full 360° data set is obtained using these weights.
CONLOAD---a new lot release rule for semiconductor wafer fabs (1999)

We present CONLOAD (CONstant LOAD), a new lot release rule for wafer fabs. It was developed to overcome some performance problems of traditional lot release rules such as CONWIP or Workload Regulation during product mix changes. We show that CONLOAD outperforms CONWIP and Workload Regulation with respect to keeping the bottleneck utilization at a desired level and to provide a smooth evolution of the WIP.
Temporal expression of myogenic regulatory genes during activation, proliferation, and differentiation of rat skeletal muscle satellite cells (1994)

Abstract The satellite cell is responsible for growth and repair of postnatal skeletal muscle. We investigated the expression of the myogenic regulatory gene (MRG) family in these cells in the stages from quiescence to fusion. Using polymerase chain reaction amplification of reverse‐transcribed RNA (RT‐PCR) isolated from adult rat satellite cells, we demonstrated a temporal sequence of gene activation, which is distinct from that previously observed in embryonic somitic cells. No MRG expression was detected in predominantly quiescent cells. MyoD is activated by 12 h in cell culture, prior to the first evidence of proliferation. MRF4 and myf‐5 appear by 48 h and may be associated with the first division cycle. Myogenin is not detectable until 72 h after satellite cell recovery from the muscle fiber, coincidental with the first evidence of differentiation. © 1994 wiley‐Liss, Inc.
Enantiospecific Synthesis of Analogues of the Diketide Intermediate of the Erythromycin Polyketide Synthase (PKS) (1998)

The four stereoisomers of 3-hydroxy-2-methylpentanoic acid (1a–d) and the structurally modified acids 1e–j have been synthesised enantiospecifically and converted into p-nitrophenyl ester and thioester derivatives; as the activated derivatives; they are available for investigations into the substrate selectivity of polyketide synthase (PKS) domains.
Feedback EDF scheduling exploiting dynamic voltage scaling (2004)

Dynamic voltage scaling (DVS) is a promising method for embedded systems to exploit multiple voltage and frequency levels and to prolong battery life. However, pure DVS techniques do not perform well for systems with dynamic workloads where the job execution times vary significantly. We present a novel approach combining feedback control with DVS schemes targeting hard real-time systems with dynamic workloads. Our method relies strictly on operating system support by integrating a DVS scheduler and a feedback controller within the EDF scheduling algorithm. Each task is divided into two portions. Within the first portion, the objective is to exploit frequency scaling for the average execution time. We reserve enough time for the second portion to meet the deadline requirements up to the worst-case execution time following a last-chance approach. Feedback techniques make the system capable to select the right frequency and voltage settings for the first potion, as well as guaranteeing hard real-time requirements for the overall task. Simulation experiments demonstrate the ability of our algorithm to save up to 29% more energy than previous work for task sets with different dynamic workload characteristics.
A genomic glimpse of aminoacyl-tRNA synthetases in malaria parasite Plasmodium falciparum (2009)

We have identified 37 Pf-aaRSs based on our bioinformatics analysis. Our data reveal several unique attributes in this protein family. We have annotated all 37 Pf-aaRSs based on predicted localization, phylogenetics, domain architectures and their overall protein expression profiles. The sets of distinct features elaborated in this work will provide a platform for experimental dissection of this family of enzymes, possibly for the discovery of novel drugs against malaria.
Laser cutting thin films for solar panels (1996)

The thin films used in the fabrication of solar panels can all be cut using lasers. Narrow tracks must be cut in order to section the films to create cells which are linked in series to generate a useful voltage from a single-sheet solar panel. Ideal tracks should be as narrow as possible to maximize the fill factor, yet still able to ensure a high electrical impedance across the cut. Each cut should not damage the underlying thin film. Track widths of the order of 15 /spl mu/m have been cut in ITO (transparent tin oxide), amorphous silicon and aluminium, and various anti-reflection layers. For the cutting process, which is extremely fast and therefore highly cost effective, the optimum laser wavelength depends upon the film itself. Machines have been constructed which use 1.06 /spl mu/m and 503 nm Nd:YAG wavelengths and 248 nm excimer laser wavelength.