gebhart/patrepeval huggingface dataset:
Functional Digital Mock-up and the Functional Mock-up Interface – Two Complementary Approaches for a Comprehensive Investigation of Heterogeneous Systems (2011)

Functional Digital Mock-up (FDMU) and Functional Mock-up Interface (FMI) are two keywords arising in the last years in simulation technology. In this paper, we would like to show that both principles, aiming at a comprehensive investigation of heterogeneous systems, e.g. from mechatronics, are not necessarily competing with each other but may be combined to benefit from the ideas behind. The approaches are based on different ideas and cover different aspects of the interaction of modern simulation tools. For that reason different constraints have to be considered, which do not make things easier. Both principles have advantages and disadvantages. However, by combining both ways, a powerful framework for handling a broad variety of simulation tasks can be formed. In the paper, a possible approach for integrating both technologies will be shown.
Effects of signal peptide mutations on processing of Bacillus stearothermophilus  -amylase in Escherichia coli (1995)

Bacillus stearothermophilus alpha-amylase has a signal peptide typical for proteins exported by Gram-positive bacteria. There is only one signal peptidase processing site when the protein is exported from the original host, but when it is exported by Escherichia coli, two alternative sites are utilized. Site-directed mutagenesis was used to study the processing in E. coli. Processing sites for 13 B. stearothermophilus alpha-amylases carrying mutations in their signal peptide were determined. Processing of the signal peptide was remarkably tolerant to mutations, because switching between the alternative sites was possible. The length and the sequence of the region between the hydrophobic core and the cleavage site was crucial for determining the choice of the processing site. Some mutations more distal to the cleavage site also affected the site preference.
Genetic Parameters and Trends of Milk, Fat, Days Open, and Body Weight After Calving in North Carolina Experimental Herds (2000)

The main objective of this study was to estimate genetic trends for 3.7% FCM, fat yield, days open, and predicted body weight after calving in six experimental dairy herds owned by the State Farm Division of the North Carolina Department of Agriculture. Body weights were predicted from heart girths measured at or before the first test day after calving. Data analyzed were 23,052 records from 8575 cows, daughters of 681 bulls. Heritabilities and breeding values were estimated using the multiple-trait, derivative-free REML programs and a single-trait repeatability model. Breeding values of cows were averaged by and regressed on birth year to estimate genetic trends. Genetic correlations between traits were estimated by correlating breeding values. Estimates of heritability were 0.25 for 3.7% FCM, 0.28 for fat yield, 0.03 for days open, and 0.17 for predicted body weight. Unfavorable genetic relationships were found between yields and days open and between yields and body weight. Genetically, cows that were heavier after calving produced less milk and fat but conceived earlier than smaller cows. Genetic changes in yields and days open were greater for cows born after 1970, but the greatest genetic changes were after 1980 (FCM, 94.7 kg/yr; fat yield, 3.46 kg/yr; days open, 1.1 d/yr). Breeding values for body weight increased for cows born from 1950 to 1970, decreased until 1980, and increased for later parities. The results of our study suggest that AI organizations may need to include fertility traits in progeny testing and relax the emphasis on increased body weight.
The Antigenicity of Polyvinyl Pyrrolidone 1,   (1956)

Summary Although it has been demonstrated that PVP of very high molecular weight (K-87) is antigenic in man, these findings have little bearing with regard to the consideration of PVP K-30 as a suitable plasma expander. PVP was not antigenic in the rabbit under all of the conditions of immunization used. Evidence has been presented that the material precipitated by PVP was specific antibody. The estimation of the level of antibody in different individuals at various times indicated a persistence in some volunteers and a disappearance in others.
Hydrogen Embrittlement of High Strength Steels in High Pressure Hydrogen Gas at Ambient Temperature (1978)

It is well known that the ductility and notched tensile strength of steels are reduced in high pressure hydrogen gas. Since some high strength steels are used for the vessels to contain high pressure hydrogen gas, it is important to study this embrittlement phenomenon for the safety of the vessels. From this point of view, the steels generally used for vessels, AISI 4340, AISI 4130 and a high manganese steel were tested in hydrogen gas at 200kg/cm2 and their embrittlement phenomena were investigated by means of fracture mechanics. In addition, the fracture morphology was observed by the scanning electron microscope and the following results were obtained.(1) Critiral stress intensity factor (KH) of the steels increases rapidly when the strengths become lower than 90kg/mm2 by tempering.(2) The fracture morphology changes from hydrogen embrittlement quasi-cleavage fracture to intergranular fracture as the stress intensity factor decrases or the strength of the steels increases.(3) From comparison with other environments to cause hydrogen embrittlement, it is realized that the high pressure (200kg/cm2) hydrogen gas is a severe emvironment almost corresponding to the pure water saturated with H2S.
An overview of clinical spectrum and heterogeneity of spondyloarthropathies. (1992)

Ankylosing spondylitis and related spondyloarthropathies form a family of rheumatic diseases that are characterized by inflammatory peripheral and axial arthritis, with predilection for sacroiliitis, and a remarkably strong association with a genetic marker, HLA-B27. The association with B27 has provided a great impetus to the epidemiologic studies of spondyloarthropathies and also helped broaden the clinical spectrum of these diseases. There are at least six subtypes of B27, and the x-ray crystallographic structure of the common B27 subtype (B*2705) is now known. Endogenous peptides bound in the B27 antigen-binding cleft have been isolated and all seem to be nonamers (i.e., nine amino acids long).
Hard x-ray quantitative non-interferometric phase-contrast microscopy (1999)

We report the results of quantitative phase-contrast imaging experiments using synchrotron radiation, in-line imaging geometry and a non-interferometric phase retrieval technique. This quantitative imaging method is fast, simple, robust, does not require sophisticated x-ray optical elements and can potentially provide submicron spatial resolution over a field of view of the order of centimetres. In the present experiment a spatial resolution of approximately 0.8 m has been achieved in images of a polystyrene sphere using 19.6 keV x-rays. We demonstrate that appropriate processing of phase-contrast images obtained in the in-line geometry can reveal important new information about the internal structure of weakly absorbing organic samples. We believe that this technique will also be useful in phase-contrast tomography.
Heparin surface modified intraocular lenses (1992)

Two types of intraocular lenses (IOLs) were used in a controlled, randomized, double-masked clinical trial. The study lens was a one-piece, poly(methyl methacrylate) (PMMA) lens with heparin grafted on the entire surface. The control lens was identical in all respects but lacked the heparin surface. The IOLs were implanted in the capsular bag after extracapsular cataract extraction in 266 patients. No unexpected reactions or severe complications occurred. The postoperative visual acuity of all cases at the three-month visit was 20/40 or better in 91.6% of the heparin group and in 86.2% of the control group. When excluding cases with preoperative pathology, 97% of the heparin group and 95% of the control group had a visual acuity of 20/40 or better. A mild iritis was observed in one case of the heparin group and in four cases of the control group at three months. At three months there was a statistically significant difference between the heparin surface modified and control IOLs for both the number of patients with cellular precipitates and the number of precipitates per IOL. From the present data we conclude that during the first three postoperative months heparin surface modified lenses are more biocompatible than PMMA lenses.
A Self Bit Synchronizer Matched to the Signal Shape (1971)

A suboptimum self bit synchronizer is considered that matches the signal shape, i. e., operates making a clever use of the knowledge of the signaling waveform. The noise performance of this system is analyzed for high signal-to-noise ratios, and an expression is obtained for the variance of the timing errors. This variance is compared with that of systems proposed by other authors on the basis of equal closed-loop noise bandwidth and equal signal shape. It is found that the use of this matched synchronizer enables appreciable timing jitter reductions.
Microalgal Flocculation Of Chlorella Vulgaris By Alteration Of pH (2009)

Flocculation of chlorella vulgaris using NaOH in the pH range 8.5 to 11.00 was studied and the cell counts of 399 x 10 with a turbidity of 0.353 OD . The flocculation efficiency is very sensitive to pH and the cell concentration. The results of the algal 660 th flocculation by pH alteration were very effective at 10.38 pH on 14 day of the incubation of the culture and reached the flocculation efficiency upto 98.50 0.34 % with recovery of total lipid upto 94.44 %.
Automatically Tuned Linear Algebra Software (1998)

This paper describes an approach for the automatic generation and optimization of numerical software for processors with deep memory hierarchies and pipelined functional units. The production of such software for machines ranging from desktop workstations to embedded processors can be a tedious and time consuming process. The work described here can help in automating much of this process. We will concentrate our efforts on the widely used linear algebra kernels called the Basic Linear Algebra Subroutines (BLAS). In particular, the work presented here is for general matrix multiply, DGEMM. However much of the technology and approach developed here can be applied to the other Level 3 BLAS and the general strategy can have an impact on basic linear algebra operations in general and may be extended to other important kernel operations.
Baculoviral expression of telomerase in primary human fibroblasts to rejuvenate cells for tissue engineering (2011)

Tissue engineering involves the use of synthetic or natural materials as a scaffold to support the growth of replacement tissue or organs. The use of autologous cells to populate the scaffold avoids problems associated with rejection; however, a major limitation of this approach is the finite lifespan of primary cells in culture. This finite lifespan is due to the shortening of telomeres, short repetitive sequences of DNA located at the ends of eukaryotic chromosomes. Ectopic expression of telomerase reverse transcriptase (hTERT) is able to reconstitute telomerase activity and maintain the length of telomeres. This study investigated an alternative gene delivery vector, baculovirus, for the expression of hTERT in primary human cells. A recombinant baculovirus was used to efficiently deliver the hTERT gene to primary fibroblasts and the telomerase enzyme was found to be active. Although no increase in telomere length was detected, expression of hTERT in primary fibroblasts resulted in a significant extension of replicative lifespan. To our knowledge this is a novel attempt to use a recombinant baculovirus for the extension of cellular lifespan by exogenous expression of telomerase.
Gas-liquid chromatographic study of the thermodynamics of solution of some aromatic compounds. III. Solutions and associative interaction with tetrachloroterephthalate esters (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas-liquid chromatographic study of the thermodynamics of solution of some aromatic compounds. III. Solutions and associative interaction with tetrachloroterephthalate estersStanley H. Langer, Bruce M. Johnson, and John R. ConderCite this: J. Phys. Chem. 1968, 72, 12, 4020–4030Publication Date (Print):November 1, 1968Publication History Published online1 May 2002Published inissue 1 November 1968https://doi.org/10.1021/j100858a014Request reuse permissionsArticle Views31Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts
<i>Local Factors in the Pathogenesis and Course of Experimental Ascites</i> (1958)

The evolution of the ascites of hepatic venous congestion was studied in dogs, following constriction of the thoracic inferior vena cava. Ascites developed in accordance with measurable changes in the transmembrane forces responsible for the net flux of fluid between extracellular fluid compartments. On the other hand, the volume of ascitic fluid could be modified with infinitesimal changes in transcompartmental pressure gradient. Although increased venous pressure appears to be the initial factor in the formation of the ascites of hepatic venous congestion, a most important factor is the permeability of the liver capsule which is stressed by elevated transmural pressure. Transudation of liver tissue fluid results. In this type of ascites, indirect calculations of the effective portal or mesenteric capillary pressure from the colloidal osmotic pressure difference between blood plasma and ascitic fluid, in accordance with the Starling equilibrium equation, are quite erroneous. Paradoxically, the ascites of venous congestion of the liver may disappear spontaneously, in spite of no reduction in the degree of hepatic venous hypertension, because of fibrosis of the liver capsule which reduces its permeability to water crystalloid and colloid. Submitted on May 19, 1958
[Sodium humate in the treatment of osteoarthrosis patients]. (2000)

The authors' study of sodium humate balneotherapy in rehabilitation of osteoarthrosis patients has shown that such balneotherapy produces analgetic, antiinflammatory and lipid modulating effects, improves metabolic processes. Low concentration of the preparation and lack of effects of other mud factors make sodium humate procedures rather tolerable. Osteoarthrosis patients can apply the procedure in home setting.
Speech-enabled mobile learning application (2006)

Mobile devices have recently gained global popularity for business and commercial uses like alerts and instant messaging. Yet, not much has been done to extend the usage of these devices in electronic learning. This paper explores the extension of e-learning into wireless/handheld (W/H) computing devices via speech-enabled discussion forum application. Discussion forums (or boards) are widely used in e-learning as a surrogate for classroom interaction among students and instructor. While these tools are relatively easy to use on a personal computer they become cumbersome on W/H devices. Speech recognition technology has the potential of overcoming this user interface problem by using text-to-speech technology and interactive voice recognition (IVR) technology for voice activated user navigation. This project attempts to develop an application using current generation of speech technology to facilitate online learning via W/H devices. Application requirements and systems architecture are presented for discussion and a prototype is being developed for pilot testing with students in online courses at our university. Results from this exploratory study will hopefully lead to proper investments in mobile applications and more research on understanding the role of speech recognition with W/H devices.
Using metalearning to predict when parameter optimization is likely to improve classification accuracy (2014)

Abstract. Work on metalearning for algorithm selection has often been criticized because it mostly considers only the default param-eter settings of the candidate base learning algorithms. Many have indeed argued that the choice of parameter values can have a signif-icant impact on accuracy. Yet little empirical evidence exists to pro-vide definitive support for that argument. Recent experiments do sug-gest that parameter optimization may indeed have an impact. How-ever, the distribution of performance differences has a long tail, sug-gesting that in most cases parameter optimization has little effect on accuracy. In this paper, we revisit some of these results and use met-alearning to characterize the situations when parameter optimization is likely to cause a significant increase in accuracy. In so doing, we show that 1) a relatively simple and efficient landmarker carries sig-nificant predictive power, and 2) metalearning for algorithm selection should be effected in two phases, the first in which one determines whether parameter optimization is likely to increase accuracy, and the second in which algorithm selection actually takes place. 1
Cloning of a cDNA Encoding<i>N</i>-Acetylglucosaminyltransferase I from Rat Liver and Analysis of Its Expression in Rat Tissues (1994)

We isolated a cDNA of N-acetylglucosaminyltransferase I (GnT-I) from rat liver and analyzed GnT-I mRNA expression in several rat tissues. We found that GnT-I mRNA was expressed in a tissue-specific manner and the pattern of its expression was suggested to be species-specific by comparison with the reported result in mice.
[Molecular modification and artificial evolution of microbial enzymes]. (2000)

There exists a remarkably progress in molecular modification and artificial evolution of microbial enzymes in recent years. Error-prone polymerase chain reaction and DNA shuffling have been developed and successfully applied and a lot of startling achievements have been obtained in artificial evolution of enzymes.
Molecular analysis of <i>NOZZLE</i> , a gene involved in pattern formation and early sporogenesis during sex organ development in <i>Arabidopsis thaliana</i> (1999)

Sexual reproduction is a salient aspect of plants, and elaborate structures, such as the flowers of angiosperms, have evolved that aid in this process. Within the flower the corresponding sex organs, the anther and the ovule, form the male and female sporangia, the pollen sac and the nucellus, respectively. However, despite their central role for sexual reproduction little is known about the mechanisms that control the establishment of these important structures. Here we present the identification and molecular characterization of the NOZZLE (NZZ) gene in the flowering plant Arabidopsis thaliana. In several nzz mutants the nucellus and the pollen sac fail to form. It indicates that NZZ plays an early and central role in the development of both types of sporangia and that the mechanisms controlling these processes share a crucial factor. In addition, NZZ may have an early function during male and female sporogenesis as well. The evolutionary aspects of these findings are discussed. NZZ encodes a putative protein of unknown function. However, based on sequence analysis we speculate that NZZ is a nuclear protein and possibly a transcription factor.
Multivariable Robust Control for a Red–Green–Blue LED Lighting System (2010)

This paper proposes a novel control structure for a red-green-blue (RGB) LED lighting system, and applies multivariable robust control techniques to regulate the color and luminous intensity outputs. RGB LED is the next-generational illuminant for general lighting or liquid crystal display backlighting. The most important feature for a polychromatic illuminant is color adjustability; however, for lighting applications using RGB LEDs, color is sensitive to temperature variations. Therefore, suitable control techniques are required to stabilize both luminous intensity and chromaticity coordinates. In this paper, a robust control system was proposed for achieving luminous intensity and color consistency for RGB LED lighting in a three-step process. First, a multivariable electrical-thermal model was used to obtain RGB LED luminous intensity, in which a lookup table served as a feedforward compensator for temperature and power variations. Second, robust control algorithms were applied for feedback control design. Finally, the designed robust controllers were implemented to control the luminous and chromatic outputs of the system. From the experimental results, the proposed multivariable robust control was deemed effective in providing steady luminous intensity and color for RGB LED lighting.
Protein−Acrylamide Copolymer Hydrogels for Array-Based Detection of Tyrosine Kinase Activity from Cell Lysates (2005)

We describe the development of an array-based assay for the molecular level detection of tyrosine kinase activity directly from cellular extracts. Glutathione S-transferase-Crkl (GST-Crkl) fusion proteins are covalently immobilized into polyacrylamide gel pads via copolymerization of acrylic monomer and acrylic-functionalized GST-Crkl protein constructs on a polyacrylamide surface. The resulting hydrogels resist nonspecific protein adsorption, permitting quantitative and reproducible determination of Abl tyrosine kinase activity and inhibition, even in the presence of a complex cell lysate mixture. Half-maximal inhibition (IC50) values for imatinib mesylate inhibition of GST-Crkl (SH3) phosphorylation by v-Abl in a purified system and Bcr-Abl within a K562 cell lysate were determined to be 1.5 and 20 microM, respectively. Additionally, the protein-acrylamide copolymer arrays detected CML cell levels as low as 15% in a background of Bcr-Abl- leukemic cells and provided the framework for the parallel evaluation of six tyrosine kinase inhibitors. Such a system may have direct application to the detection and treatment of cancers resulting from upregulated tyrosine kinase activity, such as chronic myeloid leukemia (CML). These findings also establish a basis for screening tyrosine kinase inhibitors and provide a framework on which protein-protein interactions in other complex systems can be studied.
Molecular aspects of T-cell differentiation (2000)

Differentiated T helper 1 (Th1) and T helper 2 (Th2) T-cells show striking differences in their patterns of cytokine expression. This process is initiated by stimulation with antigen and the cytokines IL-12 and IL-4, respectively, and requires antigen-induced transcription factors such as NFAT and cytokine-induced transcription factors such as STAT4, induced by IL-12, and STAT6, induced by IL-4. This results in induction and maintained expression of subset-specific transcription factors including T-bet in Th1 cells and GATA3 in Th2 cells, which are involved in ensuring the commitment of T-cells to Th1 or Th2 lineages. Here we review the signalling pathways and transcription factors that mediate T-cell differentiation, and describe the epigenetic changes in chromatin structure, locus accessibility and DNA methylation that are known to accompany this process.