gebhart/patrepeval huggingface dataset:
Cryptophycin 52 and cryptophycin 55 in sequential and simultaneous combination treatment regimens in human tumor xenografts. (2000)

The antitumor activity of cryptophycin 52 (C52) and cryptophycin 55 (C55) in sequential and simultaneous combination treatment regimens in human tumor xenografts models was explored. The antitumor activity of C52 and C55 was compared alone and in sequential combination with gemcitabine or paclitaxel in four lung cancer models, H460 and Calu-6 NSCLC and SW2 and H82 small cell lung carcinoma. The combination of C52 followed by gemcitabine was additive in three tumors and greater-than-additive in the fourth. The combination of C55 followed by gemcitabine was additive in three tumors and less-than-additive in the fourth. The combination of C52 followed by paclitaxel was greater-than-additive in one tumor, additive in one tumor and less-than-additive in two tumors. The combination of C55 followed by paclitaxel was greater-than-additive in two tumors and less-than-additive in two tumors. The simultaneous combination of C52 or C55 with fractionated radiation therapy was assessed in the H460 NSCLC tumor. Both cryptophycins produced a tumor response that was additive along with radiation therapy. The HCT116 colon carcinoma was used to compare the antitumor activity of simultaneous or sequential combination of 5-fluorouracil or irinotecan with C52. C52 produced greater-than-additive tumor response when administered either simultaneously with or sequentially with 5-fluorouracil or iriniotecan. Finally, when administered to animals bearing intraperitoneal OVCAR-3 ovarian carcinoma, C52, docetaxel and paclitaxel resulted in mean survival times of 123, 80 and 85 days compared with 72 days in the untreated controls. In combination with carboplatin, C52, docetaxel and paclitaxel resulted in mean survival times of 140, 105 and 135 days. Cryptophycins have the potential to be useful chemotherapeutic agents in a wide variety of clinical combinations regimens.
SYNCHRONIZATION AND MULTIPLE GROUP SERVER SUPPORT FOR KEPLER (2006)

In the last decade literally thousands of digital libraries have emerged but one of the biggest obstacles for dissemination of information to a user community is that many digital libraries use different, proprietary technologies that inhibit interoperability. Kepler framework addresses interoperability and gives publication control to individual publishers. In Kepler, OAI-PMH is used to support "personal data providers" or "archivelets".". In our vision, individual publishers can be integrated with an institutional repository like Dspace by means of a Kepler Group Digital Library (GDL). The GDL aggregates metadata and full text from archivelets and can act as an OAI-compliant data provider for institutional repositories. The basic Kepler architecture and it working have been reported in earlier papers. In this paper we discuss the three main features that we have recently added to the Kepler framework: mobility support for users to switch transparently between traditional archivelet s to on-server archivelets, the ability of users to work with multiple GDLs, and flexibility to individual publishers to build an OAI-PMH compliant repository without getting attached to a GDL.
Ultra sensitive TV detector measurements (2005)

This paper investigates the performance of FFT- type feature TV detector of weak signals, which can be used in listen-before-talk (LBT) spectrum access algorithms. Using FFT plots applied to consecutive sets of measurements collected at multiple locations, we illustrate and characterize different types of spurious signal environments. Ultra sensitive TV detectors can significantly improve the overall system performance in terms of available TV channels versus transmit power. We show the system performance curves based on real measurements collected at multiple locations
High-speed characterization of submicrometer giant magnetoresistive devices (1999)

A microwave test structure has been designed to measure the high-speed response of giant magnetoresistive (GMR) devices. The test structure uses microwave transmission lines for both writing and sensing the devices. Pseudo-spin-valve devices, with line widths between 0.4 and 0.8 μm, were successfully switched with pulses whose full width at half-maximum was 0.5 ns. For small pulse widths τpw the switching fields are observed to increase linearly with 1/τpw. The increase in switching fields at short pulse widths is characterized by a slope which, for the current devices, varies between 4 and 16 μA s/m (50–200 Oe ns). The magnetoresistive response during rotation and switching was observed. For small rotations (∼45° between layer magnetizations) the GMR response pulses had widths of 0.46 ns, which is at the bandwidth limit of our electronics. For larger rotations (∼90°) the response pulses broadened considerably as the magnetic layers were rotated near the unstable equilibrium point perpendicular to the device axis. Full 180° switches of both soft and hard layers were observed with switching times of approximately 0.5 ns.
Noninvasive Stratum Corneum Sampling and Electron Microscopical Examination of Skin Barrier Integrity: Pilot Study with a Topical Glycerin Formulation for Atopic Dermatitis (2012)

Small treatment cohort.
Fabrication of Photonic Transfer DNA-Quantum Dot Nanostructures (2005)

The fabrication of viable linear DNA photonic/electronic transfer nanostructures is an important prerequisite for the subsequent self-assembly into higher-order 2D/3D devices, structures and materials (high density memory, photonic antennas, nanoscale “fiber optics”, nanocomputers, nanosensors etc.). Unfortunately, it is very difficult to maintain the self-assembling and self-recognition properties of derivatized molecules such as biotin functionalized DNA sequences, when attempting to further derivatize the structure with multiply functionalized nanoparticles (streptavidin-quantum dots, gold nanoparticles, fluorescent polymer nanoparticles). Generally, overwhelming intra- and intermolecular crosslinking reactions prevent the formation of viable linear structures. Our goal is the development of nanofabrication techniques which will allow quantum dot functionalized linear DNA chains to be constructed without the need for complex chemical blocking group procedures.
A taxonomic study of the <i>Lotus corniculatus</i> complex in Turkey (1984)

A combination of morphology, chromosome number, and elevation is presently employed to circumscribe and identify the "species" Lotus corniculatus s. str., L. tenuis, and L. alpinus. Ordination analysis of morphological characters indicated continuity of variation. Moreover, moderate correlations were found between most of the characters examined and altitude, suggesting that variation was clinal rather than discontinuous. To examine the relationship between altitude and the taxa, the plants were initially grouped using only altitude as a criterion variable, lowland, moderate altitude, and upper altitude groups, respectively, representing L. tenuis, L. corniculatus, and L. alpinus. Iterative canonical analysis of the morphological data was used to refine the composition of these, and the resulting groups indeed proved to correspond to traditional conceptions of the three taxa. Because more than 40% of the morphological variation useful for discriminating these was explainable simply by the altitudinal gradient, it appears that their taxonomic delimitation amounts partly to an arbitrary trichotomization of a morphological–altitudinal continuum. Chromosome analysis of 29 populations indicated that most plants identifiable as L. corniculatus are tetraploid (2n = 4x = 24), but plants referable to L. tenuis and L. alpinus are either diploid or tetraploid. The taxa of the L. corniculatus complex in Turkey exhibit differences in morphology, chromosome number, and ecology but overlap so notably in these respects that current knowledge is doubtfully adequate for their recognition as species.
Automatic lung segmentation in CT images using watershed transform (2005)

The preprocessing step of most computer-aided diagnosis (CAD) systems for identifying the lung diseases is lung segmentation. We present a novel lung segmentation technique based on watershed transform, which is fast and accurate. Lung region is precisely marked with internal and external markers. The markers are combined with the gradient image of the original data and watershed transform is applied on the combined data to find the lung borders. Rolling ball filter is used to smooth the contour and fill the cavities while preserving the original borders. The proposed method eliminates the tasks of finding an optimal threshold and separating the attached left and right lungs, which are two common practices in most lung segmentation methods and require a significant amount of time. We have applied our new approach on several pulmonary CT images and the results reveal the speed, robustness and accuracy of this method.
Spinal Cord and Nerve Root Monitoring in Spine Surgery and Related Procedures (1996)

Intensive research in the field of intraoperative neurophysiologic monitoring has been performed directed at finding reliable stimulating and recording techniques and adequate anesthetic regimes applicable to spinal procedures. The aim is a comprehensive monitoring not only of afferent and efferent spinal cord pathways but also of sensory and motor nerve roots and cauda equina fibers. Conventional somatosensory evoked potentials (SEPs) are complemented by motor evoked potentials, dermatomal sensory evoked potentials, spinal cord evoked potentials, evoked electromyography, sensory and motor fiber mapping of the cauda equina, bulbocavernosus reflex testing, and neurogenic evoked potentials. Apart from describing the essentials of these techniques and their indications and limitations, this article deals with the influence of anesthetic management on the production and interpretation of evoked potentials.
Three-Level Converter Topologies With Switch Breakdown Fault-Tolerance Capability (2008)

This paper presents some modified topologies of the neutral-point-clamped converter. In all of them, the main change consists of adding a fourth leg, which is based on the flying-capacitor converter structure. The aim of this additional leg is to provide the converter with fault tolerance. Furthermore, during normal operation mode, this leg is able to provide a stiff neutral voltage. Consequently, the low-frequency voltage oscillations that appear at the neutral point of the standard three-level topology in some operating conditions no longer exist. As a result, the modulation strategy of the three main legs of the converter does not have to take care of voltage balance, and it can be designed to either achieve optimal output voltage spectra or improve the efficiency of the converter. Simulation and experimental results are presented to show the viability of this approach both under normal operation mode and in the event of faults.
Efficient VLSI-realizable decimators for sigma-delta analog-to-digital converters (2003)

The authors introduce a class of efficient linear-phase FIR (finite impulse response) decimators for attenuating the out-of-band noise generated by a sigma-delta modulator. These decimators contain no general multipliers and very few data memory locations, thereby making them easily realizable in CMOS VLSI. This is achieved by using several decimation stages, with each stage containing a small number of delays and arithmetic operations. The output sampling rate of these decimators is the minimum possible one, and the proposed decimators can be used, with very slight changes, for many oversampling ratios. Furthermore, these decimators highly attenuate the undesired out-of-band signal components of the input signal, thus significantly relaxing the antialiasing prefilter requirements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rational synthesis of organic thin films with exceptional long-range structural integrity (2015)

Highly oriented, domain-boundary-free organic thin films could find use in various high-performance organic materials and devices. However, even with state-of-the-art supramolecular chemistry, it is difficult to construct organic thin films with structural integrity in a size regime beyond the micrometer length scale. We show that a space-filling design, relying on the two-dimensional (2D) nested hexagonal packing of a particular type of triptycene, enables the formation of large-area molecular films with long-range 2D structural integrity up to the centimeter length scale by vacuum evaporation, spin-coating, and cooling from the isotropic liquid of the triptycene. X-ray diffraction analysis and microscopic observations reveal that triptycene molecules form a completely oriented 2D (hexagonal triptycene array) + 1D (layer stacking) structure, which is key for the long-range propagation of structural order.
A 0.3mm<sup>2</sup> 90-to-770MHz fractional-N Synthesizer for a digital TV tuner (2010)

A 0.3 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> fractional-N synthesizer covering the frequency range from 90 to 770 MHz needed for a digital TV tuner is presented. The synthesizer achieves the specifications of the ISDB-T/Tsb/Tmm standards while maintaining low spurious signals and small area by combining an FIR filtering technique and a circulating register. The phase noise at 1 MHz offset is -119 dBc/Hz. The worst spurious signals are below -61.2 dBc.
A compressed domain video object segmentation system (2003)

A fast means of object segmentation in a video sequence using low-level features existing in the compressed video stream is presented. These features include the DCT coefficient values of I-frames and motion vectors. The work described here is the foundation of a spatial segmentation system that approaches real time. Potential applications for the system include the separation of foreground and background objects and video database searching.
Distinct properties of the cAMP-responsive element of the rat insulin I gene. (1994)

The cAMP response element (CRE)-binding transcription factor CREB can mediate induction of gene transcription in response to calcium as well as to cAMP. Since the rat insulin I gene 5'-flanking region contains a CRE with an octamer-like motif (TGACGTCC), CREB binding and cAMP/calcium responsiveness of the insulin CRE were investigated. In an electrophoretic mobility shift assay and in Southwestern blot experiments, bacterially expressed recombinant CREB bound to the insulin CRE as it did to the rat glucagon and rat somatostatin gene CREs. However, in nuclear extracts of the pancreatic islet cell line HIT, protein complexes binding to the insulin CRE did not contain proteins with CREB-like immunoreactivity, although these bound to the glucagon and somatostatin CREs. When reporter fusion genes were transfected into HIT cells, the isolated insulin CRE increased basal activity and mediated transcriptional activation by cAMP. However, cAMP stimulation of transcription through the insulin CRE was weak when compared with the response through the glucagon and somatostatin CREs. Furthermore, the insulin CRE did not confer responsiveness to membrane depolarization and calcium influx, in contrast to the glucagon and somatostatin CREs. These results demonstrate that the functional properties of the rat insulin I gene CRE are different from those of the rat glucagon and somatostatin CREs which may be explained by a distinct pattern of nuclear protein binding and suggest the existence of post-translational mechanisms that decrease the binding of cellular CREB to the insulin CRE.
A Novel Approach to the Synthesis of Some Chemically-Modified Cyclodextrins (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Novel Approach to the Synthesis of Some Chemically-Modified CyclodextrinsPeter R. Ashton, Sue E. Boyd, Giuseppe Gattuso, Edward Y. Hartwell, Rainer Koeniger, Neil Spencer, and J. Fraser StoddartCite this: J. Org. Chem. 1995, 60, 12, 3898–3903Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/jo00117a049https://doi.org/10.1021/jo00117a049research-articleACS PublicationsRequest reuse permissionsArticle Views856Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors III. Effect of Ring Opening of Piperazinone Moiety on Inhibition (2004)

Compounds containing an ethylenediamine structure in place of the piperazine ring of M55113 (1) and M55551 (2) were synthesized to investigate the effects of a piperazine moiety and evaluated for activity as factor Xa (FXa) inhibitors. Most such compounds, however, exhibited lower activity (1/10-1/100) than that of M55113 and M55551 as FXa inhibitors.
Handling Concept Drifts in Regression Problems – the Error Intersection Approach (2020)

Machine learning models are omnipresent for predictions on big data. One challenge of deployed models is the change of the data over time—a phenomenon called concept drift. If not handled correctly, a concept drift can lead to significant mispredictions. We explore a novel approach for concept drift handling, which depicts a strategy to switch between the application of simple and complex machine learning models for regression tasks. We assume that the approach plays out the individual strengths of each model, switching to the simpler model if a drift occurs and switching back to the complex model for typical situations. We instantiate the approach on a real-world data set of taxi demand in New York City, which is prone to multiple drifts, e.g. the weather phenomena of blizzards, resulting in a sudden decrease of taxi demand. We are able to show that our suggested approach outperforms all regarded baselines significantly.
Quoist Michel — La ville et l'homme. Rouen, étude sociologique d'un secteur prolétarien, suivie de conclusions pour l'action (1954)

Girard Alain. Quoist Michel — La ville et l'homme. Rouen, étude sociologique d'un secteur prolétarien, suivie de conclusions pour l'action. In: Population, 9ᵉ année, n°1, 1954. p. 157.
Optimization of Diesel Engine Operating Parameters Using Neural Networks (2003)

<div class="htmlview paragraph">Neural networks are useful tools for optimization studies since they are very fast, so that while capturing the accuracy of multi-dimensional CFD calculations or experimental data, they can be run numerous times as required by many optimization techniques. This paper describes how a set of neural networks trained on a multi-dimensional CFD code to predict pressure, temperature, heat flux, torque and emissions, have been used by a genetic algorithm in combination with a hill-climbing type algorithm to optimize operating parameters of a diesel engine over the entire speed-torque map of the engine. The optimized parameters are mass of fuel injected per cycle, shape of the injection profile for dual split injection, start of injection, EGR level and boost pressure. These have been optimized for minimum emissions. Another set of neural networks have been trained to predict the optimized parameters, based on the speed-torque point of the engine. These networks can be thought of as ‘engine maps’ and have been used to simulate the emissions of the engine over the FTP heavy duty diesel cycle. Improvements resulting from the optimization have been recorded. The entire process of getting optimized parameters for an engine, starting from raw engine data or CFD results is capable of being automated and has been shown to take a reasonably small amount of computational time.</div>
Fast Dynamic Vehicle Detection in Road Scenarios Based on Pose Estimation with Convex-Hull Model (2019)

Dynamic vehicle detection is of great significance for the safety of autonomous vehicles and the formulation of subsequent driving strategies. A pose-estimation algorithm, namely, the pose estimation with convex-hull model (PE-CHM), is proposed in this paper, and introduced in the dynamic vehicle detection system. In PE-CHM, the convex hull of the object's point-clouds is first extracted and the most fitted bounding box is determined by a multifactor objective function. Next, the center position of the target is inferred according to the location and direction of the target. With the obtained bounding box and the position inference, the pose of the target is determined, which reduces the interference of the missing contour on pose estimation. Finally, three experiments were performed to validate the performance of the proposed PE-CHM method. Compared with several typical model-based methods, PE-CHM can implement dynamic vehicle detection faster, which reduces the amount of calculation on the basis of ensuring detection efficiency.
Systemic vascular resistance: an unreliable index of left ventricular afterload. (1986)

Systemic vascular resistance (SVR) is a frequently used clinical index of left ventricular afterload. However, SVR may not adequately assess left ventricular afterload (i.e., ventricular internal fiber load during systole) since it reflects only peripheral vasomotor tone. In contrast, left ventricular end-systolic wall stress (sigma es) reflects the combined effects of peripheral loading conditions and left ventricular chamber pressure, dimension, and wall thickness. To determine the relationship between SVR and sigma es, left ventricular afterload and contractility were pharmacologically altered in eight dogs instrumented with central aortic microtip and Swan-Ganz thermodilution catheters. Left ventricular wall thicknesses and dimensions were measured from two-dimensionally targeted M mode echocardiograms. Aortic, right atrial, and left ventricular end-systolic pressures as well as cardiac output were recorded. SVR and sigma es were determined under control conditions as well as during infusions of nitroprusside, methoxamine, dobutamine, and norepinephrine. Control data acquired before each drug infusion were similar. When compared with baseline values, SVR underestimated the magnitude of change in left ventricular sigma es by 22% when afterload alone was decreased (nitroprusside), 54% when afterload alone was increased (methoxamine), and 50% when afterload was decreased and contractility was augmented (dobutamine). Most importantly, when afterload was minimally decreased in association with augmented contractility (norepinephrine), SVR increased by 21% while sigma es fell by 9%. Thus, discordant changes in left ventricular afterload (i.e., sigma es) and SVR can occur during pharmacologic interventions. SVR is an unreliable index of left ventricular afterload, reflecting only peripheral arteriolar tone rather than left ventricular systolic wall force. This emphasizes the fact that a true measure of left ventricular afterload must consider the interaction of factors internal and external to the myocardium.