gebhart/patrepeval huggingface dataset:
The Type II Transforming Growth Factor (TGF)-β Receptor-interacting Protein TRIP-1 Acts as a Modulator of the TGF-β Response (1998)

The transforming growth factor-beta (TGF-beta) receptor interacting protein TRIP-1 was originally identified as a WD40 repeat-containing protein that has the ability to associate with the TGF-beta type II receptor and is phosphorylated by it (1). However, its function was not known. We now show that TRIP-1 expression represses the ability of TGF-beta to induce transcription from the plasminogen activator inhibitor-1 promoter, a common reporter of the TGF-beta-induced gene expression response, but does not affect the ability of TGF-beta to inhibit cyclin A transcription. TRIP-1 can also inhibit the plasminogen activator inhibitor-1 expression induced by Smads as well as activated TGF-beta type I receptors. Its inhibitory effect is exerted by a combination of receptor-dependent and receptor-independent mechanisms. Deletion mutational analysis revealed that two distinct regions, which do not contain recognizable WD40 repeats, are required for the ability of TRIP-1 to inhibit the gene expression response. Expression of other segments of TRIP-1 increased the TGF-beta-induced gene expression response and therefore may exert a dominant negative phenotype. We conclude that TRIP-1 acts as a modulator of the TGF-beta response.
CAN-based passenger car starter information integrated control method and its implementation (2009)

CAN (controller area network) applied in passenger car provides information sharing platform for ECUs (electronic control units). It is essential to implement passenger car information integrated control for enhancing safety, comfort, and added-value of passenger car. As a typical mechanical and electric device relating to efficiency and safety of passenger car start process, passenger car starter is easy to be damaged because of improper operation and therefore decrease its using life. In this paper, CAN-based passenger car starter information integrated control method and system implementation are studied. According to traditional passenger car starter control method and disadvantages, the current improved methods of starter control are reviewed. Based on the requirement analysis of passenger car starter control, passenger car starter information integrated control rules are presented. Applying in-vehicle network technology, automotive electronic technology and modularization design method, CAN-based passenger car starter information integrated control system is designed and equipped in WG6100ENH model natural gas city bus.
Food engineering and process applications (1986)

Food engineering and process applications , Food engineering and process applications , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Biphasic stimulator circuit for a wide range of electrode-tissue impedance dedicated to cochlear implants (2012)

This paper presents an implementation of a least voltage drop neural biphasic stimulator circuit applied in cochlear implants. Using a double loop negative feedback topology, the output impedance of the current generator is increased, while requiring only one effective drain-source voltage drop (V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</inf> ). This allows the circuit to convey more charge into the tissue. The circuit can provide a biphasic stimulation scheme from a single ended supply with an amplitude range of 10µA up to 1.05mA for a wide range of electrode-tissue impedances, R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L</inf> =1kΩ∼10kΩ, C <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L</inf> =1nF∼10nF. The stimulation current is set by scaling a reference current using a two stage binary-weighted transistor DAC configuration (3 bits HV transistor DAC and 4 bits LV transistor DAC) to improve the speed of stimulation pulses and minimize the area of the circuit. Simulation results, using the AMS 0.18µm high-voltage CMOS process, show that the charge error within a cycle (600µs) is only 0.02%, equivalent to a DC current error of 3nA at the maximum stimulation current with a load of 10kΩ+10nF.
Comparison of monofunctional and multifunctional monomers in phosphate binding molecularly imprinted polymers (2008)

In this study, molecularly imprinted polymers (MIPs) prepared using a multifunctional and a monofunctional monomer were compared with respect to their affinities, selectivities, and imprinting efficiencies for organophosphates. This is of interest because multifunctional monomers have higher affinities than traditional monofunctional monomers for their target analytes and thus should yield MIPs with higher affinities and selectivities. However, polymers containing multifunctional monomer may also have a higher number of unselective, non-templated binding sites. This increase in background binding sites could lead to a decrease in the magnitude of the imprinting effect and in the selectivity of the MIP. Therefore, phosphate selective imprinted and non-imprinted polymers (NIPs) were prepared using a novel multifunctional triurea monomer. The binding properties of these polymers were compared with polymers prepared using a monofunctional monourea monomer. The binding affinities and selectivities of the monomers, imprinted polymers, and NIPs were characterized by NMR titration, binding uptake studies, and binding isotherms. MIPs prepared with the triurea monomer showed higher binding affinity and selectivity for the diphenylphosphate anion in organic solvents than the MIPs prepared with the monofunctional monomer. Surprisingly, the binding properties of the NIPs revealed that the polymers prepared using the multifunctional and monofunctional monomers were very similar in affinity and selectivity. Thus, the multifunctional monomers increase not only the affinity of the MIP but also enhance the imprinting effect.
Simplified Method to Isolate Highly Pure Canine Pancreatic Islets (2011)

We describe an isolation method (M2) to obtain a highly pure yield of dog islets with adequate β-cell glucose responsiveness. The isolation variables associated with the outcomes in our canine model confirm previous reports in other species, including humans.
Coded multipulse pulse-position modulation for free-space optical communications (2010)

In this letter, we address two questions concerning the application of multipulse pulse-position modulation (MPPM) for free-space optical (FSO) communications: (1) under what condition would MPPM offer a notable advantage over conventional pulse-position modulation (PPM), and (2) what practical coding scheme should be used to realize that advantage. Focusing on bandwidth-efficient FSO transmission, we find decimated MPPM constellations which are suitable for combining with binary codes and offer significant gains in terms of constellation-constrained capacity over PPM under simultaneous peak-power, average-power, and bandwidth constraints. We then consider labeling design for the popular bit-interleaved coded modulation (BICM) and devise a new multilevel coding (MLC) architecture for MPPM, which we refer to as reduced-layer MLC (RLMLC). Considering the Poisson FSO channel model as a relevant example, we provide simulative evidence that RL-MLC MPPM with off-the-shelf low-density parity-check codes can outperform any PPM scheme under the same transmission constraints.
Dicarboxylic Aciduria as an Indicator of Defective β-Oxidation in Twin Siblings with a Vomiting Sickness and Hypoglycaemia Similar to Jamaican Vomiting Sickness (1978)

Conference Article| February 01 1978 Dicarboxylic Aciduria as an Indicator of Defective β-Oxidation in Twin Siblings with a Vomiting Sickness and Hypoglycaemia Similar to Jamaican Vomiting Sickness RONALD A. CHALMERS; RONALD A. CHALMERS *Division of Inherited Metabolic Diseases, Medical Research Council Clinical Research Centre, Watford Road, Harrow, Middx. HA1 3UJ, U.K. Search for other works by this author on: This Site PubMed Google Scholar ALEXANDER M. LAWSON ALEXANDER M. LAWSON †Division of Clinical Chemistry, Medical Research Council Clinical Research Centre, Watford Road, Harrow, Middx. HA1 3UJ, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1978) 6 (1): 111–113. https://doi.org/10.1042/bst0060111 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation RONALD A. CHALMERS, ALEXANDER M. LAWSON; Dicarboxylic Aciduria as an Indicator of Defective β-Oxidation in Twin Siblings with a Vomiting Sickness and Hypoglycaemia Similar to Jamaican Vomiting Sickness. Biochem Soc Trans 1 February 1978; 6 (1): 111–113. doi: https://doi.org/10.1042/bst0060111 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search © 1978 Biochemical Society1978 Article PDF first page preview Close Modal You do not currently have access to this content.
Heat shock causes oxidative stress and induces a variety of cell rescue proteins in Saccharomyces cerevisiae KNU5377. (2006)

In this study, we attempted to characterize the physiological response to oxidative stress by heat shock in Saccharomyces cerevisiae KNU5377 (KNU5377) that ferments at a temperature of 40 degrees C. The KNU5377 strain evidenced a very similar growth rate at 40 degrees C as was recorded under normal conditions. Unlike the laboratory strains of S. cerevisiae, the cell viability of KNU5377 was affected slightly under 2 hours of heat stress conditions at 43 degrees C. KNU5377 evidenced a time-dependent increase in hydroperoxide levels, carbonyl contents, and malondialdehyde (MDA), which increased in the expression of a variety of cell rescue proteins containing Hsp104p, Ssap, Hsp30p, Sod1p, catalase, glutathione reductase, G6PDH, thioredoxin, thioredoxin peroxidase (Tsa1p), Adhp, Aldp, trehalose and glycogen at high temperature. Pma1/2p, Hsp90p and H+-ATPase expression levels were reduced as the result of exposure to heat shock. With regard to cellular fatty acid composition, levels of unsaturated fatty acids (USFAs) were increased significantly at high temperatures (43 degrees C), and this was particularly true of oleic acid (C18:1). The results of this study indicated that oxidative stress as the result of heat shock may induce a more profound stimulation of trehalose, antioxidant enzymes, and heat shock proteins, as well as an increase in the USFAs ratios. This might contribute to cellular protective functions for the maintenance of cellular homeostasis, and may also contribute to membrane fluidity.
<title>Advances In Hologram Recording Materials</title> (1971)

The paramount importance of the hologram recording process has been recognized since the pioneering work of Gabor (Ref. 1). It is evident that information lost in the recording step of holography cannot be recovered subsequently. Therefore, it is essential to carry out this step in an optimum manner, retaining as much of the original object information as possible. Since its critical na-ture was widely appreciated, it is not surprising that the effects of this recording process have been the subject of well over one hundred published papers, innumerable talks, and much unreported research. As a result of this substantial effort, many aspects of hologram recording materials and practices are now well understood. However, there remain numerous questions, a few of which will become evident in the course of this paper.
Cellular composition of atherosclerotic and uninvolved human aortic subendothelial intima. Light-microscopic study of dissociated aortic cells. (1984)

Alcoholic-alkaline dissociation was used in the study of cellular composition of human aorta. Cells were isolated from an uninvolved intima and intima with different types of atherosclerotic lesions: fatty infiltration, fatty streak, and atherosclerotic plaque. In the isolated suspension we evaluated the ratio of four previously described morphologic forms of cells: stellate, elongated, elongated with side processes, and flat cells of irregular shape. It was demonstrated that the quota of stellate cells in an atherosclerotic lesion considerably exceeds that of the normal intima. For elongated cells the opposite is true. The other two cell forms are represented in the uninvolved and atherosclerotic intima in approximately equal proportions. Alteration of the ratio of different morphologic forms occurs because of the fact that the number of cells belonging to different morphologic forms increases disproportionately in the lesion zone. Specifically, the number of stellate cells is increased much more substantially, compared with elongated cells.
Use of Concept Lattices for Data Tables with Different Types of Attributes (2012)

In this paper we describe the application of Formal Concept Analysis (FCA) for analysis of data tables with different types of attributes. FCA represents one of the conceptual data mining methods. The main limitation of FCA in classical case is the exclusive usage of binary attributes. More complex attributes then should be converted into binary tables. In our approach, called Generalized One-Sided Concept Lattices, we provide a method which deal with different types of attributes (e.g., ordinal, nominal, etc.) within one data table. Therefore, this method allows to create same FCA-based output in form of concept lattice with the precise many-valued attributes and the same interpretation of concept hierarchy as in the classical FCA, without the need for speci c uni ed preprocessing of attribute values.
Optimized atomic flux from a frequency-modulated two-dimensional magneto-optical trap for cold fermionic potassium atoms (2017)

We present our study on enhancement and optimization of potassium-40 (K40) atomic beam flux from a two-dimensional magneto-optical trap (2D MOT) by modulating the frequency of cooling laser. The laser cooling beam frequencies of the 2D MOT were effectively broadened via electro-optical modulators at 10 MHz, with a modulation index ranging from β=0 to 7, depending on the laser intensity. Laser parameters of the 2D MOT beams and the magnetic field gradient were scanned for optimal settings for maximum atomic beam flux. When compared to a conventional 2D MOT with fixed laser frequencies, we were able to obtain a 3.7 times enhancement of the atomic flux when the total laser power was 640 mW. Numerical calculations predict further improvement for higher laser beam intensities.
Iterative image transformations for an automatic screening of cervical smears. (1979)

The new generation of image analysis systems permits the use of iterative image transformations. It is now possible to construct algorithms where the elementary steps are not arithmetic operations but image transformations. This will be illustrated by two examples. In the first, the absorption image of Feulgen Stained nuclei is processed by contrast algorithms in order to detect suspect cells. In the second, free lying cells are separated from overlapping cells and other artefacts by the use of skeletonization procedures.
[Oral contraceptive and anesthesia]. (2010)

Current oral contraceptive (OCs) use is associated with a fivefold increased risk of perioperative venous thromboembolism (VTE). Although the absolute number of patient who develops perioperative VTE when taking OCs is small (15-25 per 100,000 person-years), the newer OC contains desogestrel as progestogen (the third generation OC) is found to have slightly greater risk of VTE than the older OCs. "WHO criteria for the use of oral contraceptive, third edition (2004)" classifies only the major surgery with prolonged immobilization as "Category 4" where oral contraceptive is not to be used. On the contrary, Japanese Ministry of Health, Labour and Welfare prohibits OCs in all kinds of surgery. Although the restraint of perioperative OCs administration is invalid, it would be prudent to halt perioperative OCs in Japan.
Quantitative separation of bacteria in saline solution using lanthanide Er(III) and a magnetic field (1992)

A trivalent lanthanide ion, erbium (Er3+), has been used in combination with a magnetic separation technique to isolate seven bacterial species from suspensions in 0.9% saline. Erbium has an exceptionally high atomic magnetic moment of 9.3 Bohr magnetons, and following addition as ErCl3 (final concentration 5 mM) to bacterial suspensions, it imparts the magnetic moment to the bacterial cells by ionic binding to the cell surface. Strains of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus epidermidis, Staphylococcus saprophyticus and Enterococcus faecalis were obtained from the Quality Control Depository of The Cleveland Clinic Foundation, Cleveland, Ohio, USA as suspensions in 0.9% NaCl, in concentrations ranging from 10(2) to 10(8) c.f.u. ml-1. Bacteria were separated from solution inside a capillary flow cell exposed to a highly non-homogeneous magnetic field (maximum field intensity was 0.4 T) and quantified by a light scattering method. The quantity of cellular deposition in the magnetic field was correlated with the initial concentration of cells in the suspension, expressed in c.f.u. ml-1, and sample volume (1.5 and 3.0 ml), sample pH (prior to ErCl3 addition), affinity to Gram stain (negative vs positive) and species.(ABSTRACT TRUNCATED AT 250 WORDS)
아파트 단지 가로의 주민이용행위 분석 (2002)

본 연구는 이와 같은 가로이용행위가 과연 도로의 계획유형과 관계가 있는가를 해명하고자 하였다. 도로계획유형은 지금까지의 선행연구와 단지계획실무에서 보편적으로 보차병행, 보행전용, 보차공존 등으로 구분되고 있다 (한국토지개발공사, 1989; 이규인, 이재준, 1996). 이런 계획유형에 따라 가로이용행위에 차이가 있는가를 규명하는 것이 연구의 주요 내용에 포함된다. 그러나 연구의 주요 관점은 유형구분 또는 기능분화에 따른 주민이용의 차이를 일관되게 주장하는 일련의 관련 선행연구를 검증 보완하는데 있는 것이 아니다. 본 연구는, 반대로, 아파트 단지 가로에서의 행위가 가로계획유형과 무관할 수 있다는 가능성에 주목하고 있다. 가로이용행위의 차이는 보차병행도로, 보행자전용도로와 같은 유형적 구분에 기인하는 것이 아니라 이와는 별개의 어떤 다른 물리적 요소와 관계가 있을 수 있기 때문이다. 그러나 본 연구의 범위가 가로이용행위와 관계하는 이런 별개의 변수를 구체적으로 해명하는 작업까지 포함하지는 못하였다. 이 작업은 본 연구의 조사방법과는 다른 보다 전략적인 방법 또는 설명을 목적으로 하는 방법론이 필요하기 때문이다. 본 연구의 의도는 주거단지계획 또는 주민 주거행위를 단순히 유형학적 관점으로 논의하는데 익숙한 지금까지의 시각을 보완 또는 개선하는데 초점을 맞추고 있다. 이것은 단지계획을 전문적 유형학이 아니라 주민이용행위에 대한 데이터를 근간으로 조망하는 시각으로의 전환을 말한다. (서론중에서)
Quality Acceptance of Juices of Two Cultivars of Muscadine Grapes Mixed with Other Juices (1985)

Abstract Juices from 2 cultivars of muscadine grapes ( Vitis rotundifolio Michx.), ‘Noble’ (dark-skinned) and ‘Carlos’ (bronze-skinned), were mixed with juices of ‘Concord’ and ‘Niagara’ grapes, cranberry or apple. ‘Noble’ juice, combined with ‘Concord’ juice, resulted in the highest quality among the dark mixtures prepared. Also, the mixtures retained most color and flavor during a 12 month storage period. ‘Carlos’ juice rated higher in quality when blended with the light-colored juices of apple and ‘Niagara’ than with the dark colored juice. The light amber color was stable during a 12 month storage period, and the flavor and overall acceptance of the mixture were rated higher than for the others.
The putative zinc‐finger protein WZF1 interacts with a <i>cis</i>‐acting element of wheat histone genes (1993)

A nonamer motif (CATCCAACG) that is one of the cis-acting elements identified in the proximal promoter region of some wheat histone genes is included in the region that interacts with the wheat DNA-binding protein, HBP (histone gene-binding protein)-2. To obtain structural and functional information about this DNA-binding protein, we attempted to isolate a cDNA clone encoding HBP-2 on the basis of its ability to bind to a nonamer-containing 38-bp DNA fragment. Southwestern screening of a wheat cDNA library with concatenated 38-residue oligonucleotides as the probe produced one candidate clone. Nucleotide sequence analyses of this cDNA clone and the corresponding genomic clone showed that the protein deduced from the nucleotide sequence consisted of 261 amino acids and contained a set of zinc-finger motifs similar to those found in many eukaryotic transcription factors. The protein, named WZF1 (wheat zinc-finger protein 1), which was expressed from the cDNA in Escherichia coli cells, bound specifically and metal-ion-dependently to the nonamer-containing oligonucleotide. The WZF1 mRNA was highly expressed in the root apexes of wheat seedlings, but less so in the proximal portion of young leaves; whereas, histone H3 mRNA was highly expressed in both tissues. The expression patterns of the WZF1 and histone H3 genes in the early stages of germination differed, expression of the WZF1 gene being almost constant but not that of the H3 gene. The relationship of WZF1 and HBP-2 and the possible role of WZF1 in the histone gene expression were discussed.
Design Guidelines for Roof Pavers against Wind Uplift (2015)

The objective of this paper is to develop guidance for design of loose laid roof pavers against wind uplift. Large-scale experiments were performed on concrete roof pavers installed on the flat roof of a low-rise building using the Wall of Wind (WOW) facility at Florida International University (FIU). Both wind blow-off tests and pressure measurements on the top and bottom surfaces of the pavers were performed. The results are used to develop specific guidelines for design of loose-laid roof pavers. Account is taken of pressure equalization, the gaps between the pavers, and the space beneath the pavers. These guidelines are intended to be simple enough to be used by designers in parallel with the usual code provisions for exterior suctions on roofs.
Stem Cells, Progenitor Cells, and Lineage Decisions in the Ovary (2014)

Exploring stem cells in the mammalian ovary has unleashed a Pandora's box of new insights and questions. Recent evidence supports the existence of stem cells of a number of the different cell types within the ovary. The evidence for a stem cell model producing mural granulosa cells and cumulus cells is strong, despite a limited number of reports. The recent identification of a precursor granulosa cell, the gonadal ridge epithelial-like cell, is exciting and novel. The identification of female germline (oogonial) stem cells is still very new and is currently limited to just a few species. Their origins and physiological roles, if any, are unknown, and their potential to produce oocytes and contribute to follicle formation in vivo lacks robust evidence. The precursor of thecal cells remains elusive, and more compelling data are needed. Similarly, claims of very small embryonic-like cells are also preliminary. Surface epithelial cells originating from gonadal ridge epithelial-like cells and from the mesonephric epithelium at the hilum of the ovary have also been proposed. Another important issue is the role of the stroma in guiding the formation of the ovary, ovigerous cords, follicles, and surface epithelium. Immune cells may also play key roles in developmental patterning, given their critical roles in corpora lutea formation and regression. Thus, while the cellular biology of the ovary is extremely important for its major endocrine and fertility roles, there is much still to be discovered. This review draws together the current evidence and perspectives on this topic.