gebhart/patrepeval huggingface dataset:
Proliferative responses to recall antigens are associated with pregnancy outcome in women with a history of recurrent spontaneous abortion. (1997)

Maternal tolerance of the fetal hemiallograft suggests that immunomodulation occurs during gestation. Therefore, recurrent spontaneous abortion (RSA) may represent a failure of the immune changes that maintain pregnancy. We hypothesized that fertile women but not women with RSA may lose their immune responses to recall antigens when pregnant. This phenomenon has been seen in immunosuppressed transplant recipients and is associated with graft survival. Therefore, we evaluated proliferative responses to recall antigens in four groups of women: group 1, nonpregnant fertile women with no history of pregnancy loss and at least one prior healthy pregnancy, n = 13; group 2, nonpregnant women with a history of three or more spontaneous abortions, n = 28; group 3, healthy pregnant women between 6 and 9 wk of gestation without a history of prior pregnancy loss, n = 15; and group 4, pregnant women between 6 and 9 wk of gestation, with a history of RSA, n = 22. Proliferative responses of peripheral blood leukocytes to the recall antigens influenza and tetanus, alloantigens, and phytohemagglutinin were determined prospectively. Positive responses (stimulation index > 3) to recall antigens (a response to either influenza or tetanus was considered positive) were as follows: group 1 (nonpregnant fertile women), 11/13 (85%); group 2 (nonpregnant RSA women), 24/28 (86%); group 3 (pregnant fertile women), 4/15 (27%) (P </= 0.007); and group 4 (pregnant RSA women), 13/22 (59%) (P = 0.032) [corrected]. In group 4, there was 100% fetal survival in the nine women who lost responsiveness to recall antigens; however, in the 13/22 patients who responded to recall antigens, 9/13 (69%) had a repeat spontaneous abortion. These findings suggest that immunosuppression, indirectly measured by proliferation to recall antigens, is necessary for early pregnancy maintenance. Furthermore, this approach may be useful for predicting pregnancy outcome for women with RSA and may provide a useful means for designing and monitoring therapies.
Performance evaluation of adaptive ARQ schemes over half duplex transmission line (1989)

An adaptive control procedure is proposed for the go-back-N and selective-repeat automatic repeat-request (ARQ) schemes. The procedure is to dynamically vary the number and length of continuously transmitted data blocks according to the bit error rate. The throughput of the adaptive ARQ schemes for a half-duplex transmission line is compared with the throughput of corresponding conventional schemes. Numerical results indicate that adaptive ARQ schemes are superior to conventional ARQ schemes when the bit error rate is not known or varies with time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Induction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1a. (1990)

Brain creatine kinase is a major enzyme of cellular energy metabolism. It is overexpressed in a wide range of tumor cell lines and is used as a tumor marker. We reported recently that the promoter of the human gene has a strong sequence similarity to the adenovirus E2E promoter. This similarity suggested that the brain creatine kinase gene may be regulated by the viral activator E1a. Experiments reported here showed that both enzyme activity and mRNA levels were induced by the oncogenic products of the E1a region of adenovirus type 5, but unlike the viral E2E promoter, which is induced predominantly by E1a domain 3, brain creatine kinase induction required domains 1 and 2. These domains are important for transformation and for the association of E1a with the retinoblastoma gene product and other cellular proteins. The induction by an oncogene of a cellular gene for energy metabolism may be of significance for the metabolic events that take place after oncogenic activation.
Lightness: A Function-Virtualizable Software Defined Data Center Network With All-Optical Circuit/Packet Switching (2015)

Modern high-performance data centers are responsible for delivering a huge variety of cloud applications to the end-users, which are increasingly pushing the limits of the currently deployed computing and network infrastructure. All-optical dynamic data center network (DCN) architectures are strong candidates to overcome those adversities, especially when they are combined with an intelligent software defined control plane. In this paper, we report the first harmonious integration of an optical flexible hardware framework operated by an agile software and virtualization platform. The LIGHTNESS deeply programmable all-optical circuit and packet switched data plane is able to perform unicast/multicast switch-over on-demand, while the powerful software defined networking (SDN) control plane enables the virtualization of computing and network resources creating a virtual data center and virtual network functions (VNF) on top of the data plane. We experimentally demonstrate realistic intra DCN with deterministic latencies for both unicast and multicast, showcasing monitoring, and database migration scenarios each of which is enabled by an associated network function virtualization element. Results demonstrate a fully functional complete unification of an advanced optical data plane with an SDN control plane, promising more efficient management of the next-generation data center compute and network resources.
Measuring the Economic Performance of the Freight Industry: Freight Economic Output (FECO) Index at the State Level (2016)

A freight economic output (FECO) index was developed using the historical employment and wage data and estimating the gross domestic product (GDP) contribution of each freight transportation sector to Maryland’s economy. This effort was motivated by the absence of defendable performance measures for the economic contribution of freight transportation services to a state economy. The aggregate FECO index parallels the Maryland GDP and the national freight service index. Interestingly, evidence of modal competition between truck and freight rail is observed. Their trends and the magnitude of the changes are generally moving in opposite directions. The findings and methodologies of the study will help decision makers understand the role that each freight mode plays in order to make more informed decisions about transportation investments.
Design of a 0.9 V 2.45 GHz Self-Testable and Reliability-Enhanced CMOS LNA (2008)

A self-testable and highly reliable low noise amplifier designed in 0.13 m CMOS technology is presented in this paper. This reliable LNA could be used to design the front-end of critical nodes in wireless local area networks to ensure data transmission. The LNA test, based on a built-in self test methodology, monitors its behavior. The test circuit is composed of one sensor and one biasing voltage sensor, and it offers high fault coverage. The high reliability is ensured by the use of redundancies. The LNA works under a 0.9 V supply voltage and the test chip has RF characteristics suitable for 802.11b/g applications. Parametric faults are injected and detected to demonstrate the efficiency of the BIST circuitry. Thanks to the switching on redundant blocks, performances are maintained and hence this proves the reliability of the methodology proposed.
Availability Improvement of Layer 2 Seamless Networks Using OpenFlow (2015)

The network robustness and reliability are strongly influenced by the implementation of redundancy and its ability of reacting to changes. In situations where packet loss or maximum latency requirements are critical, replication of resources and information may become the optimal technique. To this end, the IEC 62439-3 Parallel Redundancy Protocol (PRP) provides seamless recovery in layer 2 networks by delegating the redundancy management to the end-nodes. In this paper, we present a combination of the Software-Defined Networking (SDN) approach and PRP topologies to establish a higher level of redundancy and thereby, through several active paths provisioned via the OpenFlow protocol, the global reliability is increased, as well as data flows are managed efficiently. Hence, the experiments with multiple failure scenarios, which have been run over the Mininet network emulator, show the improvement in the availability and responsiveness over other traditional technologies based on a single active path.
Denitrification in Constructed Wetlands Used for Treatment of Swine Wastewater (2003)

Constructed wetland treatment of swine wastewater probably involves substantial denitrification. Our objective was to assess denitrification and denitrification enzyme activity (DEA) in such wetlands in relation to plant communities, N loading, carbon or nitrogen limitations, and water depth. Two wetland cells each 3.6 m wide and 33.5 m long were connected in series. One set of cells was planted with rushes and bulrushes, including soft rush (Juncus effusus L.), softstem bulrush [Schoenoplectus tabernaemontani (K.C. Gmel.) Pallal, American bulrush [Schoenoplectus americanus (Pers.) Volkart ex Schinz & R. Keller], and woolgrass bulrush [Scirpus cyperinus (L.) Kunth]. Another set was planted with bur-reeds and cattails, including American bur-reed (Sparganium americanum Nutt.), broadleaf cattail (Typha latifolia L.), and narrowleaf cattail (Typha angustifolia L.). The sets will be referred to herein as bulrush and cattail wetlands, respectively. Denitrification and DEA were measured via the acetylene inhibition method in intact soil cores and disturbed soil samples that were taken during four years (1994-1997). Although DEA in the disturbed samples was greater than denitrification in the core samples, the measurements were highly correlated (r2 > or = 0.82). The DEA was greater in the bulrush wetlands than the cattail wetlands, 0.516 and 0.210 mg N kg(-1) soil h(-1), respectively; and it increased with the cumulative applied N. The DEA mean was equivalent to 9.55 kg N ha(-1) d(-1) in the bulrush wetlands. We hypothesized and confirmed that DEA was generally limited by nitrate rather than carbon. Moreover, we determined that one of the most influential factors in DEA was wetland water depth. In bulrush wetlands, the slope and r2 values of the control treatment were -0.013 mg N kg(-1) soil h(-1) mm(-1) depth and r2 = 0.89, respectively. Results of this investigation indicate that DEA can be very significant in constructed wetlands used to treat swine wastewater.
Short pulse solid-state Raman laser and its application to laser-machining (2002)

A compact solid-state Raman pulse compressor-amplifier system was developed and 25 ps duration, 1 mJ energy pulses with 45 MW peak power were obtained at 100 Hz repetition rate. This short pulse beam was applied to PDP glass marking, copper-laminated poly-imide film cutting, and silicon wafer cutting.
Statistical analysis of antigen receptor spectratype data (2005)

The basic probability model used for spectratype analysis is the multinomial model with n, the total number of counts, indeterminate. We derive the appropriate statistics and statistical procedures for testing hypotheses regarding differences in antigen receptor distributions and variable repertoire diversity in different treatment groups. We then apply these methods to spectratype data obtained from several healthy donors to examine the differences between normal CD4+ and CD8+ T cell repertoires, and to data from a thymus transplant patient to examine the development of repertoire diversity following the transplant.
Influence of surface roughness and waviness upon thermal contact resistance (1967)

This work deals with the phenomenon of thermal resistance between contacting solids. Attention is directed towards contiguous solids possessing both surface roughness and waviness. When two such surfaces are brought together under load, they actually touch at isolated microcontacts, and the resulting real area is the sum of these microcontacts. Because of the waviness the microcontacts are confined to a region called the contour area which may occupy some fraction of the total available area. The non-uniform pressure distribution over the contour area results in microcontacts which vary in size and density. In the absence of an interstitial fluid and negligible radiation heat transfer, all the heat crossing the interface must flow through the microcontacts. A thermal analysis, based on size and spatial distribution, results in a thermal resistance equation which differs from previously developed theories. The equation is verified by liquid analog tests which show that the size and spatial distribution are very significant.
Fully Integrated Charge Sensitive Amplifier for Readout of Micromechanical Capacitive Sensors (2005)

This paper presents a charge sensitive amplifier (CSA) for readout of micromechanical capacitive sensors. The transfer function and noise performance together with noise optimisation are studied from a theoretical point of view. The feedback resistors of the CSA are implemented as long-channel MOS transistors to set the -3 dB corner frequency well below 1 kHz. The common-mode feedback is designed to keep the input common-mode level constant to achieve an accurate gain from the change in capacitance to output signal. A CSA was designed and implemented for the readout of a bulk micromachined gyroscope with a resonance frequency of 8-10 kHz and signal bandwidth of 100 Hz. A measured resolution of 2.47-3.00 aF (rms) in capacitance change integrated over the signal band is achieved. The CSA tolerates leakage currents of over 5 nA at its input.
Investigation of the random dopant fluctuations in 20-nm bulk mosfets and silicon-on-Insulator FinFETs by Ion implantation Monte Carlo simulation (2013)

In this paper, we proposed a simulation approach for studying the random dopant fluctuation (RDF) effects in the nanoscale MOSFETs using only the TCAD tools. We use this approach to simulate the RDF effects in the 20-nm gate-length bulk MOSFETs, silicon-on-insulator (SOI) single-gate (SG) and triple-gate (TG) FinFETs for demonstration. This approach utilizes the stochastic nature of the Monte Carlo (MC) simulation of ion implantation to capture the RDF phenomena in the devices. The simulation results show that the standard deviation of the threshold voltage (σV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> ) is approximately proportional to the cube root of the channel doping concentration for the conventional bulk MOSFETs. For the SOI SG and TG FinFETs, the σV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> increases much less than that of the conventional bulk MOSFETs as the channel doping concentration increases. Besides, the σV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> of the SOI TG FinFETs show about 30% to 40% reductions comparing to those of the SOI SG FinFETs. The average of the MC simulation results agrees with the implant table simulation results. The reasonable simulation results verify the validity of this TCAD simulation scheme for the RDF study.
Slit Scanning of <i>Saccharomyces cerevisiae</i> Cells: Quantification of Asymmetric Cell Division and Cell Cycle Progression in Asynchronous Culture (1990)

Slit scanning flow cytometry has been applied to the analysis of the cell cycle and cell-cycle-dependent events in Saccharomyces cerevisiae, yielding information on the low-resolution spatial distribution of cellular components in single cells of unperturbed cell populations. Because this process is rapid, large numbers of cells can be analyzed to give distributions of parameters in a given population. To study asymmetric cell division and cell cycle progression, forward-angle light scattering (FALS) signals together with fluorescence signals from acriflavine-stained nuclei have been measured in cells from exponentially growing yeast populations. An algorithm has been developed that assigns the position of the bud neck in the FALS signals so that both FALS and DNA signals can be analyzed in terms of the contributions from the mother cell and the cell bud. The data indicate that mother cell FALS, on average, remains constant while FALS due to the cell bud increases as a cell progresses through the cell cycle. By identifying mitotic cells and measuring their properties, we have found that the coefficient of variation for the distribution of FALS is smallest within the dividing cell population and largest within the newborn cell population, in accordance with the critical size control mechanism of yeast cell growth. The use of this experimental approach to provide data for statistical population models is discussed.
Vegetatives Nervensystem und Lipoide (1928)

1. Der Tonus des vegetativen Nervensystems last sich durch Lipoide beeinflussen. 2. Die Tonusanderung ist eine primare Wirkung der Lipoide. 3. Cholesterin verringert die Adrenalinempfindlichkeit.
Yield improvement of a large area magnetic field sensor array using redundancy schemes (1997)

The circuit design of a large area magnetic field sensor array (LAMSA) is described. This prototype is developed for applications in magnetic field mapping and tactile sensor arrays. To enable the production of such a large sensor system, redundancy schemes are implemented and a laser interconnection post fabrication technique is used for fault repairs. The design restructurable capabilities rely on local redundancy schemes for the sensor grid and global redundancy schemes for the surrounding control circuits. Experimental results obtained on a laser restructurable subarray of magnetic field sensor cells are shown. A study of the robustness of the local sensor grid redundancy schemes is presented.
Structural Characterization and Pharmacology of a Potent (Cys101−Cys119, Cys110−Cys117) Bicyclic Agouti-Related Protein (AGRP) Melanocortin Receptor Antagonist (2004)

Agouti-related protein (AGRP) is one of two known naturally occurring antagonists of G-protein coupled receptors. AGRP is synthesized in the brain and is an antagonist of the melanocortin-3 and -4 receptors (MC3R, MC4R). These three proteins are involved in the regulation of energy homeostasis and obesity in both mice and humans. The human AGRP protein is 132 amino acids and contains five disulfide bridges in the C-terminal domain. Previous reports of the NMR structures of hAGRP(87-132) and a truncated 34 amino acid form consisting of four disulfide bridges identified that AGRP contains an inhibitor cystine knot (ICK) structural fold, and that is the first mammalian example. Herein, we report a bicyclic hAGRP analogue that, when compared to hAGRP(87-132), possesses equal binding affinity but is 80-fold less potent at the mouse MC4R. Using NMR, computer assisted molecular modeling (CAMM), and cluster analysis, we have identified five structural families, two of which are highly populated, of this bicyclic hAGRP analogue. Computational docking experiments of this bicyclic hAGRP derivative, using a three-dimensional homology molecular model of the mouse MC4R, identified that three of the five structural families could be docked into the MC4R without problems from steric hindrance. Those three docked mMC4R-bicyclic hAGRP family structures were compared with putative hAGRP(87-132) ligand-receptor interactions previously reported (Wilczynski et al. J. Med. Chem. 2004, 47, 2194) in attempts to identify a "bioactive" conformation of the bicyclic hAGRP peptide and account for the 80-fold decreased ligand potency compared to hAGRP(87-132).
Overexpression of SOCS3 inhibits astrogliogenesis and promotes maintenance of neural stem cells (2006)

To investigate the effects of suppressors of cytokine signaling 3 (SOCS3) on neural stem cell fate, stem cells were infected with an adenoviral vector expressing SOCS3. Three days later, western blot analysis and immunocytochemical analysis revealed that the protein level of MAP2 and the number of MAP2-positive cells were significantly increased in SOCS3-transfected cells, whereas the protein level of GFAP and the number of GFAP-positive cells were significantly decreased. Furthermore, promoter assay revealed a significant reduction in the transcriptional level of signal transducer and activator of transcription 3 (Stat3) in the transfected cells. In addition, the mRNA levels of Notch family member (notch1) and inhibitory basic helix-loop-helix (bHLH) factors (hes5 and id3) were significantly up-regulated 1 day after overexpression of SOCS3. Three days after transfection, the mRNA level of hes5 was significantly decreased, whereas that of notch1 was still up-regulated. Moreover, all of SOCS3-positive cells expressed Nestin protein but did not express MAP2 or GFAP proteins. These data indicate that overexpression of SOCS3 induced neurogenesis and inhibited astrogliogenesis in neural stem cells. Our data also show that SOCS3 promoted maintenance of neural stem cells.
Removal of hepatitis B surface antigen (HBsAg) from plasma fractions. (1976)

Endogenous or deliberately added hepatitis B antigen was removed and concentrated for assay from albumin, and from coagulation factor II, VII, IX, and X concentrates as model plasma fractions. The concentrates carry considerable risk of causing hepatitis in transfused patients. The amount of antigen remaining in the fraction was estimated to be less than 1/10,000 of that detectable by the Ausria II radioimmunoassay and 1/100 of that found to be infectious when highly contaminated human sera were diluted and injected in chimpanzees. Batch fractionation methods with polyethylene glycol were used. The yield of albumin was 96 per cent and of the coagulation factors about 90 per cent.
Continuous Peridural Anesthesia. (1944)

No other journal can match Anesthesia & Analgesia for its original and significant contributions to the anesthesiology field. Each monthly issue features peer-reviewed articles reporting on the latest advances in drugs, preoperative preparation, patient monitoring, pain management, pathophysiology, and many other timely topics. Backed by internationally-known authorities who serve on the Editorial Board and as Section Editors, Anesthesia &Analgesia is your gateway to everything that is happening in anesthesia and 14 related subspecialties: Analgesia; Ambulatory Anesthesia; Anesthetic Pharmacology; Cardiovascular Anesthesia; Critical Care and Trauma; Economics, Education, and Policy; Neurosurgical Anesthesia; Obstetric Anesthesia; Pain Mechanisms; Pain Medicine; Pediatric Anesthesia; Regional Anesthesia; Patient Safety; and Technology, Computing and Simulation.