gebhart/patrepeval huggingface dataset:
NGF-dependent neurotrophic-like effects of AF102B, anM1 Muscarinic agonist, in PC12M1 cells (1995)

The non-selective muscarinic agonist oxotremorine induces atropine-sensitive neurite outgrowth in PC12 cells stably transfected with m1 muscarinic receptors. In contrast, AF102B, an M1-selective muscarinic agonist, mediated minimal neurite outgrowth in these cells. In the presence of nerve growth factor (NGF) however, it induced atropine-sensitive neurite outgrowth in almost half the cell population. AF102B mediated phosphoinositide hydrolysis, but unlike carbachol, it did not stimulate cyclic AMP accumulation in these cells. These signals were not affected by NGF, indicating that they were not directly responsible for the cholinergic neurotrophic-like response. Our observations suggest that AF102B may improve neuronal responsiveness to neurotrophic factors, and thus may provide another beneficial aspect for treating Alzheimer's disease.
Joint denoising-deconvolution approach for fluorescence microscopy (2016)

Image denoising and deconvolution are well known techniques applied to wide-field and confocal microscopy in order to restore images. The methods however suffer from their own drawbacks with denoising potentially resulting in smoothed images while deconvolution giving unpleasant artifacts due to ill-posedness of the problem. In this paper, instead of trying to tackle the problem of low signal-to-noise ratio (SNR) images in microscopy imaging, through regularization or using denoising as a pre-processing step to deconvolution, we propose to evaluate the interest of restoring the unknown image through a joint denoising and deconvolution program applied simultaneously in an iterative framework. We propose to minimize four different energy functional arising through different combination of regularizing terms and evaluate the gain obtained by this approach. Simultaneously addressing the two problems, we demonstrate on synthetic images that a join approach is able to provide superior qualitative and quantitative results, both in the case of low and high noise scenarios. We further illustrate the performances of this approach on a real image.
CD31 <sup>+</sup> Cells Represent Highly Angiogenic and Vasculogenic Cells in Bone Marrow (2010)

These data indicate that BM-CD31(+) cells represent highly angiogenic and vasculogenic cells and can be a novel and highly promising source of cells for cell therapy to treat ischemic cardiovascular diseases.
SmartSwitch: blurring the line between network infrastructure & cloud applications (2014)

A revolution is beginning in communication networks with the adoption of network function virtualization, which allows network services to be run on common off-the-shelf hardware--even in virtual machines--to increase flexibility and lower cost. An exciting prospect for cloud users is that these software-based network services can be merged with compute and storage resources to flexibly integrate all of the cloud's resources.

We are developing an application aware networking platform that can perform not only basic packet switching, but also typical functions left to compute platforms such as load balancing based on application-level state, localized data caching, and even arbitrary computation. Our prototype memcached-aware smart reduces request latency by half and increases throughput by eight fold compared to Twitter's TwemProxy. We also describe how a Hadoop-aware switch could automatically cache data blocks near worker nodes, or perform some computation directly on the data stream. This approach enables a new breed of application designs that blur the line between the cloud's network and its servers.
Behavorial model of carbon nanotube programmable resistors (2009)

Hybrid Nano (e.g. Nanotube, Nanowire) /CMOS circuits combine both the advantages of Nano-devices and CMOS technologies; they have thus become one of the most promising candidates to relax the intrinsic drawbacks of CMOS circuits beyond Moore's law. A behavioral simulation model for an hybrid Nano/CMOS design is presented in this paper. It is based on Optically Gated Carbon NanoTube Field Effect Transistors (OG-CNTFET), which can be used as 2-terminal programmable resistors. Their resistance can be adjusted precisely, reproducibly and in a non-volatile way, over three orders of magnitude. These interesting behaviors of OG-CNTFET promise great potential for developing the non-volatile memory and neuromorphic adaptive computing circuits. The model is developed in Verilog-A language and implemented on Cadence Virtuoso platform with Spectre 5.1.41 simulator. Many experimental parameters are included in this model to improve the simulation accuracy.
GEM optimizing compilers for Alpha AXP systems (2002)

Presents a technical description of the GEM compiler technology, a multilanguage retargetable compiler system. The authors describe a number of optimization techniques that GEM compilers use to exploit the features of Alpha AXP systems. They discuss techniques used to optimize pipelining, multiple instruction issue, and memory references. Branch optimization examples are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Thermal characterization of single-wall carbon nanotube bundles using the self-heating 3ω technique (2006)

In this work, we have developed a complete solution for the thermal transport in single-wire based 3ω experiment and have studied the effect of radiation on the experiment. Microscale Pt wires are used as the reference sample to measure its specific heat and thermal conductivity. Sound agreement between the measurement data and reference values is obtained. A series of experiments is conducted to characterize the thermal transport property of single-wall carbon nanotube (SWCNT) bundles. The average thermal diffusivity measured for three different SWCNT bundles is around 1.74×10−5m2∕s, much less than the thermal diffusivity of bulk graphite in the layer direction. Physical reasons for this low thermal diffusivity are discussed based on our structure study of the SWCNT bundles.
Switchable thin film add/drop filter (2003)

A five-cavity, 117 layer, 200 GHz thin film add/drop filter fabricated from combined dielectric/semiconductor materials is thermo-optically switched between transmission and reflection at a fixed channel 1548.3 nm with a contrast ratio 18.4 dB.
A Cellular-Array Multiplier for GF(2<sup>m</sup>) (1971)

This note describes a cellular array that computes the product of two arbitrary elements of the Galois field GF(2m). The regularity of this array should make it attractive for LSI fabrication.
Affinity chromatography (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAffinity chromatographyGary R. GrayCite this: Anal. Chem. 1980, 52, 5, 9–15Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://pubs.acs.org/doi/10.1021/ac50055a002https://doi.org/10.1021/ac50055a002research-articleACS PublicationsRequest reuse permissionsArticle Views368Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Avoidance and suppression of compensation code in a trace scheduling compiler (1994)

Trace scheduling is an optimization technique that selects a sequence of basic blocks as a trace and schedules the operations from the trace together. If an operation is moved across basic block boundaries, one or more compensation copies may be required in the off-trace code. This article discusses the generation of compensation code in a trace scheduling compiler and presents techniques for limiting the amount of compensation code: avoidance (restricting code motion so that no compensation code is required) and suppression (analyzing the global flow of the program to detect when a copy is redundant). We evaluate the effectiveness of these techniques based on measurements for the SPEC89 suite and the Livermore Fortran Kernels, using our implementation of trace scheduling for a Multiflow Trace 7/300. The article compares different compiler models contrasting the performance of trace scheduling with the performance obtained from typical RISC compilation techniques. There are two key results of this study. First, the amount of compensation code generated is not large. For the SPEC89 suite, the average code size increase due to trace scheduling is 6%. Avoidance is more important than suppression, although there are some kernels that benefit significantly from compensation code suppression. Since compensation code is not a major issue, a compiler can be more aggressive in code motion and loop unrolling. Second, compensation code is not critical to obtain the benefits of trace scheduling. Our implementation of trace scheduling improves the SPEC mark rating by 30% over basic block scheduling, but restricting trace scheduling so that no compensation code is required improves the rating by 25%. This indicates that most basic block scheduling techniques can be extended to trace scheduling without requiring any complicated compensation code bookkeeping.
Enzymatic synthesis of amides with two chiral centres (1990)

R. Brieva, F. Rebolledo and V. Gotor, J. Chem. Soc., Chem. Commun., 1990, 1386 DOI: 10.1039/C39900001386
The relationship between serum levels of insulin and sex hormone-binding globulin in men: the effect of weight loss. (1994)

It is known that there is an inverse relationship between the serum levels of insulin and sex hormone-binding globulin (SHBG) in women, but the relationship in men has not been reported. It is not known whether changes in the one cause changes in the other, or whether they change in opposite directions in response to some third factor. Because obesity raises insulin levels and lowers SHBG levels in both sexes, we proposed to study the cause-effect question by determining whether the relationship between changes in SHBG and insulin levels during active weight loss. We studied 70 healthy weight-stable men with body mass index (BMI) from 20.7-94 (normal, 22.5 +/- 2.5) and restudied 17 of them during diet-induced weight loss. Fasting serum insulin levels in the weight-stable men showed a positive linear correlation with BMI, increasing 1 microU/mL per unit increase in BMI (P < 0.0001). SHBG levels in the weight-stable men showed a negative linear correlation with BMI, decreasing 0.2 nmol/L per unit increase in BMI (P < 0.0002). In the weight-stable men, there was an inverse hyperbolic correlation between SHBG and insulin levels; SHBG (nmol/L) = 13.1 + [30.1 divided by insulin (microU/mL)] (P < 0.002). During weight loss, insulin levels decreased at an average rate of 6.1 microU/mL per unit decrease in BMI, a much higher slope than the positive slope vs. BMI in weight stable men. During weight loss, SHBG levels increased at an average slope of 0.43 nmol/L per unit decrease in BMI, much higher than the negative slope of 0.2 nmol/L per unit increase in BMI in weight-stable men. Values for the SHBG vs. insulin coordinates in the weight-losing subjects did not differ significantly from those expected from the SHBG vs. insulin equation in weight-stable subjects. The stability of the SHBG-insulin relationship during weight loss despite the profoundly altered relationship of each separate component to BMI strongly suggests a close metabolic link between SHBG and insulin. As SHBG is not known to alter the production or metabolism of insulin, whereas insulin has been shown in vitro to decrease the synthesis of SHBG, it seems a reasonable conclusion that the predictable inverse relationship between serum insulin and SHBG indicates that insulin controls SHBG synthesis in vivo.
The Influence of Different Types of <i>ω</i>3 Polyunsaturated Fatty Acids on Blood Lipids and Platelet Function in Healthy Volunteers (1983)

1. Five healthy subjects took a daily supplement of 20 ml of linseed oil for 2 weeks. After a break of at least 6 weeks, the same subjects took a similar amount of MaxEPA (a fish oil fraction) for 2 weeks. The linseed oil supplement provided 9.38 g of linolenic acid (18:3 ω3) and the MaxEPA supplement provided 3.03 g of eicosapentaenoic acid (20:5 ω3) and 2.93 g of docosahexaenoic acid (22:6 ω3). The effects of the supplements on plasma lipid concentrations and on the fatty acid composition of platelet phosphoglycerides were studied. 2. In a second experiment, five male subjects took 5, 10 and 20 g of MaxEPA/day in random order for 3 week periods; each experimental period was separated by a break of at least 6 weeks. These doses of MaxEPA provided 0.83, 1.67 and 3.33 g of 20:5 ω3 and 0.80, 1.61 and 3.22 g 22:6 ω3 respectively. The effects of these supplements on plasma lipid concentrations, the fatty acid composition of platelet phosphoglycerides, template bleeding time and platelet aggregation induced by collagen and the prostaglandin analogue compound U46619 were studied. 3. In the platelet lipids, the proportion of 20:5 ω3 was increased by the 20 ml linseed oil supplement but the increase was small compared with the increase brought about by even 5 g of MaxEPA/day. The proportion of arachidonic acid (20:4 ω3) was substantially decreased by the MaxEPA supplement but not by the linseed oil supplement. The ratio of 20:4 ω6/20:5 ω3 fell from 32:1 in the control periods to 11:1 with 5 g, 7:1 with 10 g and 5:1 with 20 g of MaxEPA/day. The MaxEPA supplement also led to increases in the proportions of 22:5 ω3 and 22:6 ω3 and decreases in those of 20:3 ω6 and 22:4 ω6. 4. Bleeding times tended to be prolonged with the MaxEPA supplement but did not follow any dose-dependent trend. Platelet aggregation induced by both collagen and compound U46619 was not inhibited in vitro. 5. Plasma triglyceride concentrations were lowered by the MaxEPA supplement but not by the linseed oil supplement. Plasma triglyceride concentrations were substantially lowered by 10 g and 20 g of MaxEPA/day. Total plasma cholesterol concentrations were slightly lowered and HDL cholesterol concentrations were slightly increased by 20 g of MaxEPA/day. No other significant differences were noted.
Using Genetic Prediction from Known Complex Disease Loci to Guide the Design of Next-Generation Sequencing Experiments (2013)

A central focus of complex disease genetics after genome-wide association studies (GWAS) is to identify low frequency and rare risk variants, which may account for an important fraction of disease heritability unexplained by GWAS. A profusion of studies using next-generation sequencing are seeking such risk alleles. We describe how already-known complex trait loci (largely from GWAS) can be used to guide the design of these new studies by selecting cases, controls, or families who are most likely to harbor undiscovered risk alleles. We show that genetic risk prediction can select unrelated cases from large cohorts who are enriched for unknown risk factors, or multiply-affected families that are more likely to harbor high-penetrance risk alleles. We derive the frequency of an undiscovered risk allele in selected cases and controls, and show how this relates to the variance explained by the risk score, the disease prevalence and the population frequency of the risk allele. We also describe a new method for informing the design of sequencing studies using genetic risk prediction in large partially-genotyped families using an extension of the Inside-Outside algorithm for inference on trees. We explore several study design scenarios using both simulated and real data, and show that in many cases genetic risk prediction can provide significant increases in power to detect low-frequency and rare risk alleles. The same approach can also be used to aid discovery of non-genetic risk factors, suggesting possible future utility of genetic risk prediction in conventional epidemiology. Software implementing the methods in this paper is available in the R package Mangrove.
A Transient Detection Algorithm For Audio Using Iterative Analysis Of Stft. (2011)

[TODO] Add abstract here.
Integrin regulation of cell signalling and motility (2004)

Integrins clearly play a key role in regulating both mitogenic signalling and cell migration. Thus integrins modulate the efficiency of the Erk (extracellular-signal-regulated kinase)/MAP kinase (mitogen-activated protein kinase) pathway, acting at several distinct levels. We have shown that both cAMP-dependent protein kinase and PAKs (p21-activated kinases) play a role in integrin regulation of the Erk pathway, acting primarily at the level of Raf-1. Integrins and PAKs also play a role in the control of cell migration. Thus we have discovered a novel protein that links the alpha5beta1 integrin to migration controlled by Rho-family GTPases. This protein, termed Nischarin, is a large cytosolic macromolecule that is not related to well-known protein families. The N-terminus of Nischarin interacts with a short segment of the cytoplasmic domain of the alpha5 integrin subunit. Overexpression of Nischarin alters actin organization and inhibits Rac-driven cell migration and tumour cell invasion. Use of effector domain mutants of Rac suggest that Nischarin acts downstream of Rac, probably at the level of PAK-family kinases. These studies emphasize the intricate connection between integrins and Rho-family GTPases and their effectors in controlling both mitogenesis and migration.
A Novel Polyimide Film Preparation and Its Preferential‐Like Chemical Etching Techniques for GaAs Devices (1983)

A novel chemical etching technique using etchants composed of hydrazine hydrate and ethylene diamine to generate V‐shape grooves in thick polyimide films through photoresist masks has been developed. The etching characteristics, in terms of etch rate, side etched width and taper angle, have been found to depend strongly on (i) preparation condition of the films, especially baking temperature, and (ii) the composition and temperature of the etchants. In order to achieve preferential etching behavior, the polyimide films have been fabricated by repeating 3 times a coating process, which consists of a spin coating followed by two sequential bakings. An optimized baking condition has been found to be 15 min at 150°C in air for each prebaking and 2 min and 30 min at 185°C in for the first two and the last postbaking, respectively. An optimized condition of the etchants has also developed. Under the optimized condition, a side etched width less than 20% of the film thickness and a constant taper angle of about 35° has been achieved. The size of the V‐shape grooves has been controlled by both the opening width in the photoresist masks and the side etch rate. The taper angle of the grooves has been determined by the film preparation condition itself, and is independent of the etching time even when the films are over‐etched.
Global gene expression in Escherichia coli K-12 during short-term and long-term adaptation to glucose-limited continuous culture conditions (2006)

Microarray technology was used to study the cellular events that take place at the transcription level during short-term (physiological) and long-term (genetic) adaptation of the faecal indicator bacterium Escherichia coli K-12 to slow growth under limited nutrient supply. Short-term and long-term adaptation were assessed by comparing the mRNA levels isolated after 40 or 500 h of glucose-limited continuous culture at a dilution rate of 0.3 h(-1) with those from batch culture with glucose excess. A large number of genes encoding periplasmic binding proteins were upregulated, indicating that the cells are prepared for high-affinity uptake of all types of carbon sources during glucose-limited growth in continuous culture. All the genes belonging to the maltose (mal/lamB) and galactose (mgl/gal) operons were upregulated. A similar transcription pattern was observed for long-term cultures except that the expression factors were lower than in the short-term adaptation. The patterns of upregulation were confirmed by real-time RT-PCR. A switch from a fully operational citric acid cycle to the PEP-glyoxylate cycle was clearly observed in cells grown in glucose-limited continuous culture when compared to batch-grown cells and this was confirmed by transcriptome analysis. This transcriptome analysis confirms and extends the observations from previous proteome and catabolome studies in the authors' laboratory.
Adenovirus-Mediated Gene Transfer to Treat Neurologic Disease (1998)

Within the last 10 years the development of tools used to manipulate DNA have shown promise in the generation of a new form of therapeutic intervention known as gene therapy. Gene therapy involves the introduction of genetic material into cells to replace or supplement defective genes or to induce the expression of a novel gene to help alleviate a disease. These manipulations can be done in cells either outside the body and transplanted back in (ex vivo gene therapy) or directly within a specific target organ (in vivo gene therapy). To target and transfer DNA or RNA to cells a variety of techniques have been developed, including the use of replication-defective viruses, lipid bilayers that encapsulate DNA (liposomes), and DNA-coated gold particles that are ballistically shot into cells (gene gun). Most of these topics will be discussed in articles to follow in this series.
On the Surface Chemical Aspects of Very High Energy Density, Rechargeable Li–Sulfur Batteries (2009)

Li(metal)–sulfur (Li–S) systems are among the rechargeable batteries of the highest possible energy density due to the high capacity of both electrodes. The surface chemistry developed on Li electrodes in electrolyte solutions for Li–S batteries was rigorously studied using Fourier transform infrared and X-ray photoelectron spectroscopies. A special methodology was developed for handling the highly reactive Li samples. It was possible to analyze the contribution of solvents such as 1-3 dioxolane, the electrolyte , polysulfide , and additives to protective surface films that are formed on the Li electrodes. The role of as a critical component whose presence in solutions prevents a shuttle mechanism that limits the capacity of the sulfur electrodes is discussed and explained herein.
Video Summarization and Semantics Editing Tools (2001)

This paper describes a video summarization and semantics editing tool that is suited for content-based video indexing and retrieval with appropriate human operator assistance. The whole system has been designed with a clear focus on the extraction and exploitation of motion information inherent in the dynamic video scene. The dominant motion information has been used explicitly for shot boundary detection, camera motion characterization, visual content variations description, and for key frame extraction. Various contributions have been made to ensure that the system works robustly with complex scenes and across different media types. A window-based graphical user interface has been designed to make the task very easy for interactive analysis and editing of semantic events and episode where appropriate.