gebhart/patrepeval huggingface dataset:
Low Store Energy, Low VDDmin, 8T2R Nonvolatile Latch and SRAM With Vertical-Stacked Resistive Memory (Memristor) Devices for Low Power Mobile Applications (2012)

Many mobile SoC chips employ a “two-macro” approach including volatile and nonvolatile memory macros (i.e. SRAM and Flash), to achieve high-performance or low-voltage power-on operation with the capability of power-off nonvolatile data storage. However, the two-macro approach suffers from slow store/restore speeds due to word-by-word serial transfer of data between the volatile and nonvolatile memories. Slow store/restore speeds require long power-on/off time and leave the device vulnerable to sudden power failure . This study proposes a resistive memory (memristor) based nonvolatile SRAM (or memristor latch) cell to achieve fast bit-to-bit parallel store/restore operations, low store/restore energy consumption, and a compact cell area. This resistive nonvolatile 8T2R (Rnv8T) cell includes two fast-write memristor (RRAM) devices vertical-stacked over the 8T, and a novel 2T memristor-switch, which provides both memristor control and SRAM write-assist functions. The write assist feature enables the Rnv8T cell to use read favored transistor sizing to prevent read/write failure at lower VDDs. We also fabricated the first macro-level memristor-based (or RRAM-based) nonvolatile SRAM. This 16 Kb Rnv8T macro achieved the lowest store energy and R/W VDDmin (0.45 V) of any nonvolatile SRAM or two-macro solution.
Controlled-Release Theophylline Tablet Formulations Containing Acrylic Resins, III. Influence of Filler Excipient. (1987)

The selection of a filler excipient was demonstrated to have a dramatic effect on the release properties of theophylline from matrix tablets containg an acrylic resin polymer as the retardant substance. Theophylline tablets were formulated to contain 60 percent drug, 28 percent filler excipient, 10 percent Eudragit S100, 1.5 percent fumed silica and 0.5 percent magnesium stearate. Release rates were most rapid when microcrystalline cellulose was the filler excipient and the slowest when calcium sulfate was used as the diluent. Dissolution rates decreased in acidic medium as the level of Eudragit S100 increased from zero to fifteen percent. In pH 7.4 phosphate buffer, USP, the converse held true because of the high solubility of the resin at this pH value. There was no difference between dissolution rates at pH 1.1 and pH 4.0. Tablet porosity was influenced significantly by the filler excipient. Higher porosity usually resulted in greater theophylline dissolution rates. When sucrose was employed as the filler excipient, tablet porosity was inversely related to tablet hardness.
Fibroblast growth factor inhibits MRF4 activity independently of the phosphorylation status of a conserved threonine residue within the DNA-binding domain. (1993)

MRF4 is a member of the muscle-specific basic helix-loop-helix transcription factor family that also includes MyoD, myogenin, and Myf-5. Each of these proteins, when overexpressed in fibroblasts, converts the cells to differentiated muscle fibers that express several skeletal muscle genes, such as those for alpha-actin, muscle creatine kinase, and troponin I. Despite the fact that MRF4 functions as a positive transcriptional regulator, the MRF4 protein is subject to negative regulation by a variety of agents, most notably by exposure of cells to purified growth factors, such as basic fibroblast growth factor (bFGF). In an effort to establish whether bFGF inhibits MRF4 activity through specific posttranslational modifications, we examined whether MRF4 exists in vivo as a phosphoprotein and whether the phosphorylation status of the protein regulates its activity. Our results indicate that MRF4 is phosphorylated predominantly on serine residues, with weak phosphorylation occurring on threonine residues. Both cyclic AMP-dependent protein kinase (PKA) and protein kinase C (PKC) phosphorylate MRF4 in vitro as well as in vivo, and the overexpression of each kinase inhibits MRF4 activity and thus blocks terminal differentiation. PKC-directed phosphorylation of a conserved threonine residue (T-99) situated within the DNA-binding domain inhibits MRF4 from binding in vitro to specific DNA targets. However, although T-99 itself is essential for myogenic activity, our studies demonstrate that the phosphorylation status of T-99 does not play a major role in regulating MRF4 activity in vivo, since PKA, PKC, and bFGF inhibit the activity of MRF4 proteins in which the identified PKA and PKC sites have been mutated. We suggest that the negative regulation of MRF4 imposed by bFGF does not involve a direct modification of the protein at the identified PKA and PKC sites but instead may involve the modification of specific coregulators that interact with this muscle regulatory factor.
An Improved Small-Molecule Inhibitor of FtsZ with Superior <i>In Vitro</i> Potency, Drug-Like Properties, and <i>In Vivo</i> Efficacy (2012)

The bacterial cell division protein FtsZ is an attractive target for small-molecule antibacterial drug discovery. Derivatives of 3-methoxybenzamide, including compound PC190723, have been reported to be potent and selective antistaphylococcal agents which exert their effects through the disruption of intracellular FtsZ function. Here, we report the further optimization of 3-methoxybenzamide derivatives towards a drug candidate. The in vitro and in vivo characterization of a more advanced lead compound, designated compound 1, is described. Compound 1 was potently antibacterial, with an average MIC of 0.12 μg/ml against all staphylococcal species, including methicillin- and multidrug-resistant Staphylococcus aureus and Staphylococcus epidermidis. Compound 1 inhibited an S. aureus strain carrying the G196A mutation in FtsZ, which confers resistance to PC190723. Like PC190723, compound 1 acted on whole bacterial cells by blocking cytokinesis. No interactions between compound 1 and a diverse panel of antibiotics were measured in checkerboard experiments. Compound 1 displayed suitable in vitro pharmaceutical properties and a favorable in vivo pharmacokinetic profile following intravenous and oral administration, with a calculated bioavailability of 82.0% in mice. Compound 1 demonstrated efficacy in a murine model of systemic S. aureus infection and caused a significant decrease in the bacterial load in the thigh infection model. A greater reduction in the number of S. aureus cells recovered from infected thighs, equivalent to 3.68 log units, than in those recovered from controls was achieved using a succinate prodrug of compound 1, which was designated compound 2. In summary, optimized derivatives of 3-methoxybenzamide may yield a first-in-class FtsZ inhibitor for the treatment of antibiotic-resistant staphylococcal infections.
The symptomatic and functional outcome of stereotactic thalamotomy for medically intractable essential tremor (1992)

Eight patients with medically refractory disabling essential tremor underwent ventralis lateralis (VL) thalamotomies; the procedure was unilateral in seven cases and bilateral (staged) in the other. Contralateral tremor remained absent or markedly reduced in all patients at the time of the most recent follow-up examinations, at a mean of 17.3 months after surgery. Disability was determined by a modified form of an established rating scale for tremor, and was reduced from a mean score of 21.1 (moderate grade) to 3.9 (absent grade) (p less than 0.001). Interestingly, voice tremor was abolished or significantly improved in 71.4% of patients with preoperative voice tremor. This feature has not been reported previously. Persistent surgical morbidity was limited to two patients with mild dysarthria and one with a mild cognitive impairment. There were no surgically related deaths. It is concluded that stereotactic VL thalamotomy is a treatment option for medically intractable disabling essential tremor.
Single Electrode Deep Brain Stimulation with Dual Targeting at Dual Frequency for the Treatment of Chronic Pain: A Case Series and Review of the Literature (2017)

Deep Brain Stimulation (DBS) has been used to target many deep brain structures for the treatment of chronic pain. The periaqueductal grey and periventricular grey (PAG/PVG) is an effective target but results are variable, sometimes short-lived or subject to tolerance. The centromedian intra-laminar parafascicular complex (CMPf) modulates medial pain pathways and CMPf DBS may address the affective aspects of pain perception. Stimulation of multiple deep brain targets may offer a strategy to optimize management of patients with complex pain symptomatology. However, previous attempts to stimulate multiple targets requires multiple trajectories and considerable expense. Using a single electrode to stimulate multiple targets would help overcome these challenges. A pre-requisite of such a technique is the ability to use different stimulation parameters at different contacts simultaneously on the same electrode. We describe a novel technique in 3 patients with chronic pain syndromes for whom conventional medical and/or neuromodulation therapy had failed using a single electrode technique to stimulate PVG/PAG and CMPf at dual frequencies.
Effect of amplified spontaneous emission and absorber mirror recovery time on the dynamics of mode-locked fiber lasers (2004)

The effect of the amplified spontaneous emission (ASE) on the performance of the semiconductor saturable absorber mirrors (SESAMs) in mode-locked fiber lasers has been investigated. We show that high level of ASE intensity typical for fiber lasers can saturate the absorption and degrade significantly the nonlinear response of the SESAM. We studied the effect of the absorber recovery time and demonstrated that the ion-irradiated SESAMs with fast nonlinear response are less affected by the ASE radiation and, consequently, in the presence of the high-power ASE they exhibit better self-starting capability compared with slow absorbers.
Reconstruction with the calibrated SYCLOP sensor (2002)

In this paper we present a method of calibrating the omnidirectional sensor used in our laboratory and named SYCLOP ("Conic System for Localization and Perception"). In order to have better precision than that obtained in classical applications using this kind of sensor, we highlight the importance of calibration for the whole sensor. After this step we validate our model by a reconstruction of objects, and of an environment from two different methods, the first based on a commercial software 3DS Max/sup (R)/ and the second based on a simulator developed by us and taking parameters determined in the previous stage. The real and calculated pictures are compared, to estimate the error of reconstruction. The last part of this paper presents results obtained with the SYCLOP simulator and an experimental phase.
A Session Initiation Protocol (SIP) Event Package and Data Format for Various Settings in Support for the Push-to-Talk over Cellular (PoC) Service (2006)

The Open Mobile Alliance (OMA) is defining the Push-to-talk over Cellular (PoC) service where SIP is the protocol used to establish half-duplex media sessions across different participants, to send instant messages, etc.This document defines a SIP event package to support publication, subscription, and notification of additional capabilities required by the PoC service.This SIP event package is applicable to the PoC service and may not be applicable to the general Internet.
Portable Facial Recognition Jukebox Using Fisherfaces (Frj) (2016)

A portable real-time facial recognition system that is able to play personalized music based on the identified person’s preferences was developed. The system is called Portable Facial Recognition Jukebox Using Fisherfaces (FRJ). Raspberry Pi was used as the hardware platform for its relatively low cost and ease of use. This system uses the OpenCV open source library to implement the computer vision Fisherfaces facial recognition algorithms, and uses the Simple DirectMedia Layer (SDL) library for playing the sound files. FRJ is cross-platform and can run on both Windows and Linux operating systems. The source code was written in C++. The accuracy of the recognition program can reach up to 90% under controlled lighting and distance conditions. The user is able to train up to 6 different people (as many as will fit in the GUI). When implemented on a Raspberry Pi, the system is able to go from image capture to facial recognition in an average time of 200ms.
Comparison between infrared and ultraviolet laser ablation at atmospheric pressure—implications for solid sampling inductively coupled plasma spectrometry (1994)

The efficiency of laser solid sampling was investigated as a function of several experimental parameters under experimental conditions similar to those used for laser ablation (LA) inductively coupled plasma spectrometry. This was done by studying the amount of material removed as a function of melting temperature of the (metallic) matrix material, laser wavelength and laser energy, and by studying the plasma ignition in air and argon buffer gases as a function of laser wavelength. It was found that direct LA is the major process responsible for the removal of material in the case of a UV laser, as opposed to with an IR laser, where shielding of the laser radiation by the absorbing plasma limits direct LA and increases the temperature of the plasma. The consequences of this difference between IR and UV laser radiation are considerable and lead to a superior performance of UV laser sampling in every analytical aspect: reproducibility, matrix effects, quantification, spatial resolution and sensitivity.
Engineering of Promoter Replacement Cassettes for Fine-Tuning of Gene Expression in <i>Saccharomyces cerevisiae</i> (2006)

The strong overexpression or complete deletion of a gene gives only limited information about its control over a certain phenotype or pathway. Gene function studies based on these methods are therefore incomplete. To effect facile manipulation of gene expression across a full continuum of possible expression levels, we recently created a library of mutant promoters. Here, we provide the detailed characterization of our yeast promoter collection comprising 11 mutants of the strong constitutive Saccharomyces cerevisiae TEF1 promoter. The activities of the mutant promoters range between about 8% and 120% of the activity of the unmutated TEF1 promoter. The differences in reporter gene expression in the 11 mutants were independent of the carbon source used, and real-time PCR confirmed that these differences were due to varying levels of transcription (i.e., caused by varying promoter strengths). In addition to a CEN/ARS plasmid-based promoter collection, we also created promoter replacement cassettes. They enable genomic integration of our mutant promoter collection upstream of any given yeast gene, allowing detailed genotype-phenotype characterizations. To illustrate the utility of the method, the GPD1 promoter of S. cerevisiae was replaced by five TEF1 promoter mutants of different strengths, which allowed analysis of the impact of glycerol 3-phosphate dehydrogenase activity on the glycerol yield.
Validated HPTLC method for quantification of vitamin D<sub>3</sub>in fish oil (2011)

A selective high-performance thin-layer chromatographic (HPTLC) method for the quantification of vitamin D3 was developed and validated for the analysis of fish oils. The fish oil samples were applied onto the HPTLC plates after saponification and purification.HPTLC of fish oils was performed on Kieselgel 60 F254 (10 cm × 10 cm) plates with chloroform-ether 9:1 (ν/ν) as the mobile phase. Quantitative evaluation of the plate was performed at 280 nm without derivatization. The assay provides good accuracy, reproducibility, and selectivity for the quantitative analysis of vitamin D3. The calibration plots were linear in the range 200–1000 ng per spot. The technique was used for the estimation of the vitamin D3 content of fish oils, lipid food supplements and drugs containing vitamin D3.
Intense Pulsed Light Sintering of Electrodeposited CdS Thin Films (2014)

In order to manufacture market competitive solar cells, material processing methods with low capital and running costs are required. One method for achieving this goal would be to use atmospheric processing techniques with a high throughput. Here, we report the use of intense pulsed light (IPL) to process cadmium sulfide (CdS) thin films. IPL is an ultra‐fast and facile technique for the heat treatment of materials. Pulses of light from the UV to IR wavelengths are absorbed by the material, leading to localized heating and sintering. IPL has been used to successfully make Ag and Cu electrical contacts for use in electronic circuits, however little work exists on the use of IPL in the processing of semiconductor materials. CdS was selected due to its importance in solar cell manufacturing. This n‐type semiconductor has been used as a “window” material in high efficiency CdTe and Cu In (1 −x) Ga x Se 2 ‐based solar cells. The effect of energy input and the energy density of the pulse on the films optical, compositional and morphological properties of the films was investigated using UV–Vis spectroscopy, XRD, and SEM. IPL sintering resulted in significant improvement to the CdS crystallinity with processing times <2 mins.
Intracerebroventricular Administration of Bromocriptine Ameliorates the Insulin-Resistant/Glucose-Intolerant State in Hamsters (1999)

Bromocriptine, a potent dopamine D2 receptor agonist, suppresses lipogenesis and improves glucose intolerance and insulin resistance. Recent evidence suggests that bromocriptine may produce these effects by altering central nervous system (CNS) regulation of metabolism. To determine whether or not the CNS plays a critical role in these bromocriptine-mediated effects on peripheral metabolism, we compared the metabolic responses to bromocriptine when administered peripherally versus centrally in naturally obese and glucose intolerant Syrian hamsters. Male hamsters (BW 194 +/- 5 g) were treated with bromocriptine or vehicle either intraperitoneally (i.p., 800 microgram/animal) or intracerebroventricularly (i.c.v., 1 microgram/animal) daily at 1 h after light onset for 14 days while held on 14-hour daily photoperiods. Glucose tolerance tests (GTTs, 3 g glucose/kg BW) were conducted after treatment. Compared to control animals, bromocriptine i.p. significantly reduced weight gain (11.7 vs. -2.4 g) and the areas under the glucose and insulin GTT curves by 29 and 48%, respectively. Similarly, compared with vehicle-treated controls, bromocriptine i.c.v. at 1 microgram/animal substantially reduced weight gain (8.7 vs. -6.3 g), the areas under the glucose and insulin GTT curves by 31 and 44% respectively, and the basal plasma insulin concentration by 41% (p < 0.05). Furthermore, both treatments significantly improved insulin-mediated suppression of hepatic glucose production during a hyperinsulinemic-euglycemic clamp. Thus, daily administration of bromocriptine at a very low dose i.c.v. replicates the metabolic effects of bromocriptine administered i.p. at a much higher dose. This finding demonstrates for the first time that the CNS is a critical target of bromocriptine's metabolic effects.
A new adaptive ultrasonic technique for measuring blood vessel diameter and wall thickness (2002)

A new adaptive technique for measuring blood vessel diameter and wall thickness is presented. This technique allows one to use a target-specific transmitted waveform/receiver filter to obtain a larger signal-to-noise ratio (SNR) in the received signal than using conventional techniques. As the intensity of the transmitted wave increases the SNR in the received signal increases. However, because of the FDA limitations placed on the amount of transmit energy, it is important to be able to make the most efficient use of the energy that is available to obtain the best possible SNR in the received signal. The adaptive ultrasonic measurement technique presented here makes the most efficient use of the energy that is available by placing the maximum amount of energy in the largest target scattering mode. Here, adaptive ultrasonic measurement of blood vessel diameter is explored via computer simulations.
Running the Clock: CO<sub>2</sub> Catalysis in the Age of Anthropocene (2016)

ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTRunning the Clock: CO2 Catalysis in the Age of AnthropoceneMarc RobertView Author Information Université Paris Diderot, Sorbonne Paris Cité, Laboratoire d'Electrochimie Moléculaire, Unité Mixte de Recherche Université - CNRS 7591, Bâtiment Lavoisier, 15 rue Jean de Baïf, 75205 Paris Cedex 13, FranceCite this: ACS Energy Lett. 2016, 1, 1, 281–282Publication Date (Web):June 20, 2016Publication History Published online20 June 2016Published inissue 8 July 2016https://pubs.acs.org/doi/10.1021/acsenergylett.6b00159https://doi.org/10.1021/acsenergylett.6b00159article-commentaryACS PublicationsCopyright © 2016 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2922Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (305 KB) Get e-AlertscloseSUBJECTS:Catalysis,Catalysts,Electrical energy,Fossil fuels,Redox reactions Get e-Alerts
Altered lipopolysaccharide characteristic of the I69 phenotype in Haemophilus influenzae results from mutations in a novel gene, isn (1996)

The 169 phenotype of Haemophilus influenzae results from a mutation leading to a lipopolysaccharide molecule consisting only of lipid A and a single phosphorylated 2-keto-3-deoxyoctulosonic acid residue. In this paper we describe the identification of a gene which, when mutated, results in the 169 phenotype. We have named the gene isn. The predicted amino acid sequence of Isn is homologous to the product of the lmbN gene involved in the biosynthesis of the sugar-containing antibiotic lincomycin by Streptomyces lincolnensis. lsn is situated between two loci that are homologous to the dpp and art periplasmic permease systems in Escherichia coli. Northern (RNA) blot and primer extension analyses reveal that isn is transcribed as a monocistronic mRNA. Potential functions of Isn protein are discussed.