gebhart/patrepeval huggingface dataset:
Docosahexaenoic- and Eicosapentaenoic Acid-bound Lysophospholipids are More Effective in Suppressing Angiogenesis than Conjugated Docosahexaenoic Acid (2012)

Suppression of leukemia, colon cancer, myeloma, and fibrosarcoma to some extent by omega 3 fatty acid bound phospholipids has been reported in the last two decade. However, the anti-angiogenic activity of those phospholipids is still not known. Four kinds of marine phospholipid molecular species i.e. starfish EPA bound diacyl phospholipid (EPA-PC), EPA bound monoacyl phospholipid (EPA-LPC) which was prepare via Lipozyme RMIM mediated partial hydrolysis of EPA-PC, squid DHA bound diacyl phospholipid (DHA-PC), and DHA bound monoacyl phospholipid (DHA-LPC) which was also prepare via Lipozyme RMIM mediated partial hydrolysis of DHA-PC, were subjected to antiangiogenic activity assay by using a piece of rat main artery and a human umbilical cord vein endothelial cell. The lengths of micro vein generated from those tissues after incubation with the above four kinds of phospholipid molecular species were measured and compared. EPA-LPC and DHA-LPC showed strong antiangiogenic activity on the rat main artery tissue, while on the human umbilical cord vein endothelial cells, 100 µM of EPA-LPC in the culture medium, exhibited the most effective suppression on angiogenesis, followed by 100 µM of DHA-LPC. It was concluded that EPA-LPC obtained via Lipozyme RMIM mediated partial hydrolysis of EPA-PC is the most effective omega 3 phospholipid on anti-angiogenesis.
A modified cross power-spectrum phase method based on microphone array for acoustic source localization (2009)

The cross power-spectrum phase (CSP) method plays an important role in time delay estimate due to its efficiency in acoustic source localization. Generally, impacted by the spatial noise and reverberation in a room, the positioning accuracy could be greatly enhanced. However, this method could hardly lead to results when the energy of signal is small. In this paper, a new method is proposed: covariance matrix that from the multi-channel signals were applied and the characteristic of the coherent function was employed. Experiments under various conditions were carried out to demonstrate the new method's novelty, including adding background music to simulate the real environments. The 240 groups' data we achieved reached localization accuracy of 97.5% in normal experiments. We also obtained 85.42% and 83.75% correct rate in low and strongly musical environments, respectively.
Microfluidic magnetic cell sorting system for cancer diagnosis (2009)

This project is aimed at developing a new integrated microfluidic system for high throughput cell sorting and analysis. This micro-device will be able to sort rare population of cells, like circulating tumor cells (CTC) in whole blood, and analyze them by bright field and fluorescence microscopy at high magnification. Evaluating the concentration of CTC in blood will have a strong diagnosis and prognosis value, for evaluating risks of metastases and tumor cells dissemination. Cell sample flows through an array of magnetic columns that are coated with antibodies. These antibodies are specific of membrane protein that are expressed by the target cells and allow their capture in chip. Once they are trapped on columns, their shape and theexpression of other proteins are observed by microscopy. As a proof of concept, Raji cells (B lymphocytes, CD19+) mixed with Jurkat cells (T lymphocytes, CD19-) with an initial concentration of 1/1000 are sorted in an array of magnetic beads functionalized with anti-CD19 antibodies. 500μL of sample are analyzed within 1 hour with a global capture yield of 55 +/- 10 %. The captured cells are then stained with immunofluorescent probes which provide membrane (anti- CD19-AlexaFluor 488) and nucleus (Hoechst) imaging. Imagining can be performed at high resolution microscopy, including 100X oil immersion objectives.
Interferon-gamma- and phorbol myristate acetate-responsive elements involved in intercellular adhesion molecule-1 mRNA stabilization. (1994)

Treatment of cells with interferon (IFN)-gamma or phorbol myristate acetate (PMA) induces up-regulation of the level of intercellular adhesion molecule-1 (ICAM-1; CD54) mRNA by stabilization of an otherwise labile mRNA. Here, we have generated various deletion mutants of ICAM-1 and stably transfected them into the murine fibroblast Ltk- cells that express no endogenous ICAM-1 or -2 (CD102) in an effort to define the regions within ICAM-1 mRNA responsive to IFN-gamma or PMA. Induction of ICAM-1 mRNA in the transfected L cells by the treatment with IFN-gamma revealed that the truncation of the region of ICAM-1 mRNA encoding the cytoplasmic domain made it non-responsive to IFN-gamma whereas all other regions were dispensable. In contrast, PMA-induced accumulation of ICAM-1 mRNA required the 3'-untranslated region (UTR). To further elucidate the role of these regions in mRNA destabilization and responsiveness to IFN-gamma and PMA, ICAM-2 mRNA that is stable and not responsive to IFN-gamma or PMA was used as a reporter gene. The putative IFN-gamma-responsive region of ICAM-1 mRNA encoding its cytoplasmic domain rendered it unstable and responsive to IFN-gamma but not PMA. Conversely, the 3'-UTR of ICAM-1 fused with ICAM-2 mRNA also made it unstable and responsive to PMA but not IFN-gamma. Half-life analysis showed that the induction of these chimeric mRNAs by IFN-gamma and PMA was due, at least in part, to the prolongation of their turnover rate. These results taken together demonstrate that two distinct regions of ICAM-1 mRNA regulate its stability, one encoding the cytoplasmic domain and responsive to IFN-gamma and the other in the 3'-UTR and responsive to PMA.
Defect Structures of Tin‐Doped Indium Oxide (2003)

Defect structures associated with tin doping of indium oxide, an optically transparent conductor, have been characterized by atomistic simulations and first‐principles density functional calculations. A comprehensive survey of defect clusters containing up to three tin dopants in the first and second cationic coordination shells of an oxygen interstitial has been conducted. The analysis of energetically favorable defects gives insights into the role and nature of defect clusters in the material. In particular, the origins of the experimentally postulated b‐site preference of tin dopants have been examined. Our results show that b‐site preference occurs only in defect clusters with oxygen interstitials and is not intrinsic to dopants. In contrast, in nearest coordination to an interstitial, a strong d‐site preference is found. Density functional calculations in the discrete variational‐embedded cluster approximation have been conducted on selected defect structures to illuminate the effect of clustering on partial atomic charges, bond‐orders, and 119 Sn Mössbauer parameters.
Hepatitis and Liver Cancer (2010)

The global epidemic of hepatitis B and C is a serious public health problem. Hepatitis B and C are the major causes of chronic liver disease and liver cancer in the world. In the next 10 years, 150,000 people in the United States will die from liver disease or liver cancer associated with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. Today, between 800,000 and 1.4 million people in the United States have chronic hepatitis B and between 2.7 and 3.9 million have chronic hepatitis C. People most at risk for hepatitis B and C often are the least likely to have access to medical services. Reducing the rates of illness and death associated with these diseases will require greater awareness and knowledge among health care workers, improved identification of at-risk people, and improved access to medical care.Hepatitis B is a vaccine-preventable disease. Although federal public health officials recommend that all newborns, children, and at-risk adults receive the vaccine, about 46,000 new acute cases of the HBV infection emerge each year, including 1,000 in infants who acquire the infection during birth from their HBV-positive mothers. Unfortunately, there is no vaccine for hepatitis C, which is transmitted by direct exposure to infectious blood.Hepatitis and Liver Cancer identifies missed opportunities related to the prevention and control of HBV and HCV infections. The book presents ways to reduce the numbers of new HBV and HCV infections and the morbidity and mortality related to chronic viral hepatitis. It identifies priorities for research, policy, and action geared toward federal, state, and local public health officials, stakeholder, and advocacy groups and professional organizations.
Numerical Simulation of Bistatic Scattering From a Target at Low Altitude Above Rough Sea Surface Under an EM-Wave Incidence at Low Grazing Angle by Using the Finite Element Method (2004)

To study bistatic scattering from a target at low altitude above two-dimensional (2-D) randomly rough sea surface under an electromagnetic (EM) wave incidence at low grazing angle (LGA), a numerical approach of the finite element method (FEM) is developed. The conformal perfectly matched layer (PML), as the truncation boundary of the FEM, is employed to reduce the reflection error of planar PML in conventional FEM. Numerical code of our FEM is examined by available solution of the FBM (forward backward iterative) method. Bistatic and back-scattering from composite model of a target above randomly rough sea surface generated by Monte Carlo realization, and functional dependence upon the sea surface wind speed, target altitude, incident and scattering angles etc. are numerically demonstrated and discussed. This study presents numerical description for the observation principle and physical insight associated with the coupling interactions of a complex volumetric target and randomly rough sea surface.
Moving toward a generalizable application of central thalamic deep brain stimulation for support of forebrain arousal regulation in the severely injured brain (2012)

This review considers the challenges ahead for developing a generalizable strategy for the use of central thalamic deep brain stimulation (CT/DBS) to support arousal regulation mechanisms in the severely injured brain. Historical efforts to apply CT/DBS to patients with severe brain injuries and a proof-of-concept result from a single-subject study are discussed. Circuit and cellular mechanisms underlying the recovery of consciousness are considered for their relevance to the application of CT/DBS, to improve consciousness and cognition in nonprogressive brain injuries. Finally, directions for development, and testing of generalizable criteria for CT/DBS are suggested, which aim to identify neuronal substrates and behavioral profiles that may optimally benefit from support of arousal regulation mechanisms.
Boron removal from aqueous solution using curcumin-impregnated activated carbon (2013)

This study was conducted to investigate the batch and fixed-bed adsorption properties of boron on curcumin-impregnated activated carbon (Cur-AC). The maximum boron removal was obtained at pH5.5 and 120 min of contact time. Langmuir and Freundlich isotherm models were applied and it was determined that the experimental data conformed to both models. The Langmuir maximum adsorption capacities for Cur-AC (5.00 mg/g) and regenerated Cur-AC (3.61 mg/g) were obviously higher than the capacity for bare activated carbon (0.59 mg/g). Kinetic studies indicated the adsorption of boron conformed to the intra-particle model. The highest boron removal in fixed-bed column adsorption was achieved up to 99% for the first 5 min at an inlet concentration of 890 mg/L and a flow rate of 8.0 mL/min. Thomas and the Yoon-Nelson models gave better fit to the experimental data. Cur-AC can be reused after elution processes with slightly lower adsorption capacity.
Abstract IA22: Modeling and targeting the tumor microenvironment of pancreatic cancer (2016)

Abstract Maintenance and drug resistance of pancreatic ductal adenocarcioma (PDAC) depends on cancer cell intrinsic mechanisms and a stroma that supports tumor growth. Mouse models of human PDAC have provided important insights into the evolution of this highly lethal tumor, but there are no models that allow secondary genetic manipulation of autochthonous tumors, the tumor microenvironment or the metastatic host niche once the tumor has formed. We generated an inducible dual-recombinase system by combining Flp/frt and Cre/loxP. This novel PDAC model permits spatial and temporal control of gene expression enabling unbiased genetic approaches to study the role of tumor cell-autonomous and non-autonomous functions in endogenous cancers. This tool provides unparalleled access to the native biology of cancer cells and their hosting stroma, and rigorous genetic validation of candidate therapeutic targets. We performed tumor cell-autonomous and non-autonomous targeting, uncovered hallmarks of human multistep carcinogenesis, validated genetic tumor therapy, and showed that mast cells in the tumor microenvironment, which had been thought to be key oncogenic players, are in fact dispensable for tumor formation. Citation Format: Dieter Saur. Modeling and targeting the tumor microenvironment of pancreatic cancer. [abstract]. In: Proceedings of the AACR Special Conference: Function of Tumor Microenvironment in Cancer Progression; 2016 Jan 7–10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2016;76(15 Suppl):Abstract nr IA22.
Motion Compensation and Reconstruction of H.264/AVC Video Bitstreams using the GPU (2007)

Most modern computers are equipped with powerful yet cost-effective graphics processing units (GPUs) to accelerate graphics operations. Although programmable shaders on these GPUs were designed for the creation of 3-D rendering effects, they can also be used as generic processing units for vector data. This paper proposes a hardware Tenderer capable of executing motion compensation, reconstruction, and visualization entirely on the GPU by the use of vertex and pixel shaders. Our measurements show that a speedup of 297% can be achieved by relying on the processing power of the GPU, relative to the CPU. As an example, real-time playback of high-definition video (1080 p) was achieved at 62.0 frames per second, consuming only 68.2% of all CPU cycles on a modern machine.
Application integration environment for messaging/queueing model (2002)

The integration of a disparate set of applications in a enterprise is key for decision support functions. This has been a made feasible using a message bus as the basis of integration. The paper highlights the problems and solutions using the DAE software bus.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Studies on the Flavor or Odor Permeability of Various Types of Plastics Film (1963)

[in Japanese]
Fully integrated current-mode CMOS gated baseline restorer circuits (2002)

Design and performance results for three different fully-integrated gated baseline restorer (BLR) circuits used in a new PET current-mode front-end CMOS ASIC are presented. The BLR for each of the three gated integrator channels is a differential current-in to single ended current-out circuit with a correction bandwidth of 100 kHz set by a 40 pF on-chip capacitor using pole splitting techniques. The BLRs for the constant fraction discriminator (CFD) arming and constant fraction comparators are differential current-in to voltage-out circuits with correction bandwidths of 1 MHz and 5 MHz set by on-chip capacitors of 2.5 pF and 10 pF respectively. The BLR circuits are capable of correcting for differential input current offsets ranging from /spl plusmn/40 to /spl plusmn/160 /spl mu/A. Use of the BLR circuits allows photomultiplier tube (PMT) detector inputs to be AC coupled and all slow (gated integrator) and fast (CFD timing) signal processing channels to be DC coupled. The BLR circuits correct for count-rate dependent baseline shifts due to detector AC coupling and correct for accumulated CMOS DC offsets in the signal processing channels. Gated integrator input offset currents are maintained below 50 nA, beeping the gated integrator output error below 10 mV for an 850 ns integration period. CFD constant fraction comparator input offset is maintained at submillivolt levels, and arming comparator threshold is maintained at a 0-0.48V level under on-board DAC control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Inside-Out Regulation of FcαRI (CD89) Depends on PP2A (2008)

To achieve a correct cellular immune response toward pathogens, interaction between FcR and their ligands must be regulated. The Fc receptor for IgA, FcalphaRI, is pivotal for the inflammatory responses against IgA-opsonized pathogens. Cytokine-induced inside-out signaling through the intracellular FcalphaRI tail is important for FcalphaRI-IgA binding. However, the underlying molecular mechanism governing this process is not well understood. In this study, we report that PP2A can act as a molecular switch in FcalphaRI activation. PP2A binds to the intracellular tail of FcalphaRI and, upon cytokine stimulation, PP2A becomes activated. Subsequently, FcalphaRI is dephosphorylated on intracellular Serine 263, which we could link to receptor activation. PP2A inhibition, in contrast, decreased FcalphaRI ligand binding capacity in transfected cells but also in eosinophils and monocytes. Interestingly, PP2A activity was found crucial for IgA-mediated binding and phagocytosis of Neisseria meningitidis. The present findings demonstrate PP2A involvement as a molecular mechanism for FcalphaRI ligand binding regulation, a key step in initiating an immune response.
Low-Lying 1—States in Even-Even Nuclei (1954)

In a limited isotopic region, there have been found low-lying states in even-even nuclei of spin 1, odd parity. Other energy levels in the vicinity are the well characterized 0+, 2+, and 4+ states of the even-even nuclear type. The 1- states were identified through $\ensuremath{\alpha}\ensuremath{-}\ensuremath{\gamma}$ angular correlation measurements supported by internal conversion coefficient data.
Self-Concentration and Large-Scale Coherence in Bacterial Dynamics (2004)

Suspensions of aerobic bacteria often develop flows from the interplay of chemotaxis and buoyancy. We find in sessile drops that flows related to those in the Boycott effect of sedimentation carry bioconvective plumes down the slanted meniscus and concentrate cells at the drop edge, while in pendant drops such self-concentration occurs at the bottom. On scales much larger than a cell, concentrated regions in both geometries exhibit transient, reconstituting, high-speed jets straddled by vortex streets. A mechanism for large-scale coherence is proposed based on hydrodynamic interactions between swimming cells.
Topsentins, new toxic bis-indole alkaloids from the marine sponge <i>Topsentia</i><i>genitrix</i> (1987)

Three new bis-indole alkaloids, topsentin-A (1), -B1 (2), and -B2 (3) have been isolated from the Mediterranean sponge Topsentiagenitrix and their structure determined by spectroscopic methods. These compounds are weakly toxic for fish and for dissociated cells of the freshwater sponge Ephydatiafluviatilis and thus might be partially responsible for the chemical defense of the sponge.
The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC (1991)

Protein HC, an extremely charge-heterogeneous lipocalin, carries a yellow-brown fluorescent chromophore of unknown structure covalently bound at an unidentified site of its polypeptide chain. Two chromophore-carrying peptides with 60% of the chromophore material (defined as material absorbing light at 330 nm) were isolated from pepsin-digested native human protein HC by reversed-phase high performance liquid chromatography. Sequence analysis of these peptides indicated that the chromophore was bound to the cysteine residue at position 34 of the protein HC polypeptide chain. Sequence analysis of a native chromophore-tripeptide complex, isolated from pronase digests of the pepsin-produced peptides, identified the sequence Thr33-X34-Pro35, corroborating the position of the chromophore linkage. Quantitative amino acid analysis of the hydrolyzed, performic acid-oxidized, chromophore-tripeptide complex demonstrated approximately equal amounts of threonine, cysteic acid, and proline in the complex. Reduction and carboxymethylation of the native chromophore-tripeptide complex did not remove the chromophore from the peptide. The absorption spectrum of the chromophore-tripeptide complex was similar to that of native protein HC, implying that all of the heterogeneity of protein HC resides in its chromophore.
Image analysis using a generalised wavelet transform (1993)

The suitability of wavelet transforms (WT) for use in image analysis is well established: a representation in terms of the frequency content of local regions over a range of scales provides an ideal framework for the analysis of image features, which in general are of di#erent size and can often be characterised by their frequency domain properties [1]. However, the standard form of wavelet decomposition, based on the translation and scaling of a single mother wavelet [2], has its limitations when considering general analysis problems. Apart from its lack of shift invariance [3], it also necessarily links scale and frequency: the size of a given region determines its representative frequencies within the transform. This latter property seems particularly restrictive given that there is no reason in general to assume that the frequency content of an image region should be related to its size. Thus, although the basic advantages of a wavelet approach are well-founded, the n
Fluctuations in the Values of Nitrogen in Dal Lake of Kashmir (2012)

Nitrogen in any form is in fact a depiction of the productive status of the natural ecological systems provided its concentration is within the prescribed limit. But unregulated anthropogenic intervention in the aquatic ecosystems enhances the nitrogen content and accelerates its senescence. Dal Lake in the present area of study is under incessant human interference which has in fact reduced it to a mere sink of the refuse generated by the stakeholders living around. As a consequence of the present investigation, nitrate, nitrite and ammonia values were found to record an increase.
Learning subsumption hierarchies of ontology concepts from texts (2010)

This paper proposes a method for learning ontologies given a corpus of text documents. The method identifies concepts in documents and organizes them into a subsumption hierarchy, without presupposing the existence of a seed ontology. The method unco
Wearable computers: Merging information space with the workspace (2002)

Products of the future will be technologically more sophisticated, highly customized, produced in small batches, and brought to market quickly. These products will require an approach which integrates the application, the artifact, the CAD environment, and the physical prototyping. The EDRC is developing a comprehensive program to integrate these four activities.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Merging Two Sets of Erasable Itemsets (2016)

Erasable-itemset mining is to find the itemsets (components) that can be eliminated if the products generated from them gain profit under a given threshold. In this paper, we consider the erasable-itemset integration problem to merge the erasable itemsets from two data sources. We propose an efficient merging algorithm, which can get the merged erasable itemsets directly or by rescanning partial data sources to reduce mining time. Experiments are also made to show that the proposed algorithm executes faster than the re-mining approach for merging erasable itemsets.