gebhart/patrepeval huggingface dataset:
Kinetics and mechanism for the oxidation of ascorbic acid/ascorbate by HO2/O2- (hydroperoxyl/superoxide) radicals. A pulse radiolysis and stopped-flow photolysis study (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics and mechanism for the oxidation of ascorbic acid/ascorbate by HO2/O2- (hydroperoxyl/superoxide) radicals. A pulse radiolysis and stopped-flow photolysis studyDiane E. Cabelli and Benon H. J. BielskiCite this: J. Phys. Chem. 1983, 87, 10, 1809–1812Publication Date (Print):May 1, 1983Publication History Published online1 May 2002Published inissue 1 May 1983https://pubs.acs.org/doi/10.1021/j100233a031https://doi.org/10.1021/j100233a031research-articleACS PublicationsRequest reuse permissionsArticle Views1801Altmetric-Citations207LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Antiamebic Agents. V.<sup>1</sup> Promising Basic Amebicides Derived from 5-Chloro-8-quinolinol (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntiamebic Agents. V.1 Promising Basic Amebicides Derived from 5-Chloro-8-quinolinolJ. H. BURCKHALTER, WILLIAM S. BRINIGAR, and PAUL E. THOMPSONCite this: J. Org. Chem. 1961, 26, 10, 4070–4078Publication Date (Print):October 1, 1961Publication History Published online1 May 2002Published inissue 1 October 1961https://pubs.acs.org/doi/10.1021/jo01068a103https://doi.org/10.1021/jo01068a103research-articleACS PublicationsRequest reuse permissionsArticle Views230Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Correlation of serum total and free phenytoin levels with drug intake and seizure control (1986)

1. Sera of 92 epileptic patients, receiving phenytoin (3-7mg/kg/per day) alone/ in combination with phenobarbitone (1-2 mg/kg/day), were analysed for total and free phenytoin spectrophotometrically.

2. The respective means of total and free phenytoin in the phenytoin group were not significantly different from the phenytoin plus phenobarbitone group.

3. The relationshp between total and free phenytoin, in all patients, was curvilinear i.e. biphasic. The proportion of free phenytoin in patients with total phenytoin <20(g/ml was significantly (p<0.01) higher than those with total phenytoin <20 (g/ml

4. Compared to uncontrolled patients the controlled patients without toxicity showed no statistical differences in mean levels of total and free phenytoin; significantly higher proportion of free drug and a tendency to maintain higher levels of both free and total drug at a given dose, and a significant rise in these levels with dosage increment.

5. The mean total and free phenytoin levels in patients who developed toxicity were higher than the uncontrolled as well as controlled patients without toxicity.
Imagine: a tool for generating HTML style sheets with an interactive genetic algorithm based on genes frequencies (2003)

Presents a new interactive method called Imagine that automatically generates style sheets for Web sites. This method aims at satisfying the artistic or aesthetic preferences of the user. It uses a genetic algorithm to generate the style sheets and to find, within a search space, one or several style sheets that maximize the user's satisfaction. This genetic algorithm is interactive: it generates style sheets, it displays them, and then it asks the user to select those which look the best. In this way, the search for an optimal sheet is guided by the answers provided by the user. Also, this algorithm uses non-standard genetic operators based on gene frequencies. We present examples obtained with an actual prototype.
Sensory and sympathetic nerve contributions to the cutaneous vasodilator response from a noxious heat stimulus (2011)

We investigated the roles of sensory and noradrenergic sympathetic nerves on the cutaneous vasodilator response to a localized noxious heating stimulus. In two separate studies, four forearm skin sites were instrumented with microdialysis fibres, local heaters and laser-Doppler probes. Skin sites were locally heated from 33 to 42 °C or rapidly to 44 °C (noxious). In the first study, we tested sensory nerve involvement using EMLA cream. Treatments were as follows: (1) control 42 °C; (2) EMLA 42 °C; (3) control 44°C; and (4) EMLA 44 °C. At the EMLA-treated sites, the axon reflex was reduced compared with the control sites during heating to 42 °C (P < 0.05). There were no differences during the plateau phase (P > 0.05). At both the sites heated to 44 °C, the initial peak and nadir became indistinguishable, and the EMLA-treated sites were lower compared with the control sites during the plateau phase (P < 0.05). In the second study, we tested the involvement of noradrenergic sympathetic nerves in response to the noxious heating using bretylium tosylate (BT). Treatments were as follows: (1) control 42 °C; (2) BT 42 °C; (3) control 44 °C; and (4) BT 44 °C. Treatment with BT at the 42 °C sites resulted in a marked reduction in both the axon reflex and the secondary plateau (P < 0.05). At the 44 °C sites, there was no apparent initial peak or nadir, but the plateau phase was reduced at the BT-treated sites (P < 0.05). These data suggest that both sympathetic nerves and sensory nerves are involved during the vasodilator response to a noxious heat stimulus.
Subfamily Organization and Phylogenetic Origin of Genes Encoding Plastid Lipid-Associated Proteins of the Fibrillin Type (2004)

Plastid lipid-associated proteins of the fibrillin type have been found in a number of plants, but beyond their structural role in carotenoid-storing fibrils in chromoplasts, their functions remain poorly understood. We have identified 13 genes encoding members of this family in Arabidopsis. Some genes can be grouped in subfamilies of closer sequence similarity. Fibrillin polypeptides share typical signa- tures and potential functional domains, but appear quite diverse when other parameters are considered, namely their molecular weight, pI, or hydrophobic profiles. Most of these genes show differential expres- sion when stress- or organ-related expression is examined. An evolutionary scheme for fibrillin-related genes can be proposed. Three Arabidopsis fibrillin genes originate from relatively recent duplications, and are not found in the rice genome, which has ten orthologues. Four genes are found in a red alga. A diverse situation is found in cyanobacteria. ! -cyanobacteria have one orthologue of one plant gene and, in some species, a second gene (without plant orthologue). -Cyanobacteria have either one or two members of a third gene subfamily (without plant orthologue) or no such gene at all (in species adapted to low light). This suggests that plants multiplied their fibrillin genes from an ancestral gene that still has a relative in some cyanobacteria.
Detection of excess crystalline As and Sb in III-V oxide interfaces by Raman scattering (1977)

Raman backscattering from oxidized GaAs and InAs yielded two anomalous peaks of large scattering strength which we have concluded to be from excess As in the interface between the oxides and underlying semiconductors. Similarly, we concluded that the two anomalous peaks from GaSb and InSb are from excess interface Sb. From the frequencies, line shapes, and polarization selection rules, we deduced that the excess As and Sb are in the crystalline semimetal phase, as distinct from the amorphous phase.
Properties of High Heat-Resistance µc-SiC<sub>x</sub>:H Emitter Silicon HBT's (1989)

Properties of µc-SiC x :H prepared by plasma CVD are studied with emphasis on microcrystallite growth and thermal stability. A small percentage of carbon added to µc-Si:H effectively suppresses crystalline-grain growth which degrades the wide-bandgap effect. As a result, the µc-SiC x :H-emitter HBT yields higher current gains than the µc-Si:H-emitter HBT over the entire current range measured. Greater heat-resistance properties are also observed. Accordingly, a current gain as high as 450 is maintained even after 450°C annealing.
A specialized WFST approach for class models and dynamic vocabulary (2012)

In this paper we describe a specialized Weighted Finite State Transducer (WFST) framework for handling class language models and dynamic vocabulary in automatic speech recognition. The proposed framework has several important features, a fused composition algorithm that substantially reduces the memory usage in comparison to generic WFST operations, and an efficient dynamic vocabulary scheme that allows for arbitrary new words to be added to class based language models on-thefly without requiring any changes to the pre-compiled transducers. The dynamic vocabulary approach achieves very low run-time costs by representing the dynamic vocabulary items inserted into the language model from an optimum set of existing lexicon items. Experimental results on a voice search task illustrate the low runtime costs of the proposed approach.
Data modeling for radar applications (2004)

This paper presents the process of data modeling for generating functional {[f(x)]/sup n/} models of algorithms or data set relationships in simple polynomial form. Data modeling has been applied to missing data reconstruction, signature synthesis, interpolation, data compression, classifier performance modeling, and adaptive feature selection. This paper highlights the mathematical process and successful applications.
On-line algorithms for path selection in a nonblocking network (1990)

Nonblocking networks arise in a variety of applications involving communications. The most well known examples include telephone networks, data networks, and distributed memory architectures. Although asymptotically optimal constructions are known for nonblocking networks in a variety of models, it is generally not known how to select paths for the desired network connections efficiently on-line. In this paper, we present the first optimal-time algorithms for path selection in an optimal-size nonblocking network. In particular, we describe a bounded-degree, O(N log N)-switch nonblocking network that can realize any sequence of connections and disconnections among N terminals with O(logN) bit-step delay. Viewed in the context of a telephone switching network, our network and algorithm can handle any sequence of calls among N parties with O(log N) bit-step delay per call (even if many calls are made at once). Parties can hang up and call again whenever they like, and multiparty calls can be made without affecting the performance of the algorithm --every call is still put through in O(logN) time. Viewed in the context of distributed memories for parallel machines, our algorithm allows any processor to access any idle block of memory within O(log N) bit-steps at any time --no matter what other connections have been made previously or are being made simultaneously.
Studies on tertiary amine oxides. LXXIV. Reactions of aromatic N-oxides with 2-phenyl-2-thiazolin-4-one in the presence of acetic anhydride. (1982)

Quinoline 1-oxides (1a-e) readily react with 2-phenyl-2-thiazolin-4-one (2) in acetic anhydride at room temperature to afford the corresponding 5-(2-quinolyl) thiazolones (3a-e) in good yields. The reaction of 4-chloroquinoline 1-oxide (1f) gives 4-acetoxy-5-(4-chloro-2-quinolyl)-2-phenylthiazole (4). Hydrolyses of 1a-e with 48% hydrobromic acid under reflux give 2-quinolinemethanethiols as the hydrobromides (6a-e). Similar results were obtained from the reaction of isoquinoline 2-oxide (7), but pyridine 1-oxide was unreactive.
Guanylyl cyclase / atrial natriuretic peptide receptor-A: role in the pathophysiology of cardiovascular regulation (2011)

Atrial natriuretic factor (ANF), also known as atrial natriuretic peptide (ANP), is an endogenous and potent hypotensive hormone that elicits natriuretic, diuretic, vasorelaxant, and anti-proliferative effects, which are important in the control of blood pressure and cardiovascular events. One principal locus involved in the regulatory action of ANP and brain natriuretic peptide (BNP) is guanylyl cyclase / natriuretic peptide receptor-A (GC-A/NPRA). Studies on ANP, BNP, and their receptor, GC-A/NPRA, have greatly increased our knowledge of the control of hypertension and cardiovascular disorders. Cellular, biochemical, and molecular studies have helped to delineate the receptor function and signaling mechanisms of NPRA. Gene-targeted and transgenic mouse models have advanced our understanding of the importance of ANP, BNP, and GC-A/NPRA in disease states at the molecular level. Importantly, ANP and BNP are used as critical markers of cardiac events; however, their therapeutic potentials for the diagnosis and treatment of hypertension, heart failure, and stroke have just begun to be realized. We are now just at the initial stage of molecular therapeutics and pharmacogenomic advancement of the natriuretic peptides. More investigations should be undertaken and ongoing ones be extended in this important field.
Water Content Measured by Proton-Deuteron Exchange NMR Predicts Bone Mineral Density and Mechanical Properties (2004)

Water content could potentially serve as a surrogate measure for the bone's degree of mineralization, and this technique could be used to study other disorders of mineral homeostasis known to alter the mineralization state of the matrix. Although the method presented here is not suitable for in vivo measurements of bone water content, the authors have previously shown that 1H NMR images of bone can be acquired; thus, noninvasive quantification of bone water may be feasible.
Active Terahertz Metamaterials (2009)

We demonstrate THz metamaterials exhibiting either amplitude/phase control, via carrier injection or depletion in the active semiconductor substrate or frequency control, via photoexcitation of carriers into active semiconducting materials incorporated into the sub-wavelength metamaterial structure. (Nonlinear Optics, 2009). Download original .PDF file here: <a href="http://www.opticsinfobase.org/abstract.cfm?URI=NLO-2009-NMC1">NMC1</a>.
XLIII.—Organic derivatives of silicon. Part V. Benzylethylsilicone, dibenzylsilicone, and other benzyl and benzylethyl derivatives of silicane (1908)

R. Robison and F. S. Kipping, J. Chem. Soc., Trans., 1908, 93, 439 DOI: 10.1039/CT9089300439
Covalent Capture of Kinase Substrate Phosphopeptides for Analysis of Cellular Signaling Networks (2008)

Kinase-mediated protein phosphorylation regulates nearly every cellular signaling pathway. Protein kinases function in the integration and modulation of information flow through the regulation of signaling components and act as direct effectors of cellular processes by controlling the behavior of protein machines and cellular structural components. Approximately one third of all cellular proteins are phosphorylated, and so it is thought that many individual kinases likely have numerous (&gt;100) direct targets. A detailed understanding of this architecture will be required in order to accurately model complex cellular behaviors both normal and aberrant, to reliably predict cellular responses to therapeutic intervention in disease states, and to successfully implement cell or tissue based therapeutic strategies. Such an understanding will require a comprehensive elucidation of biologically relevant kinase-substrate interactions. At present, the discovery of such interactions represents a significant challenge. In this work we describe a novel method for rapid identification of protein kinase substrates. In this method, a kinase of interest is engineered to accept an ATP analog that allows it to uniquely label its substrates with a bio-orthogonal phosphate analog tag. A highly specific, covalent capture-and-release methodology was developed for rapid purification of tagged peptides derived from labeled substrate proteins. Mass spectrometric analysis of the recovered peptides affords identification of the parent protein species, and often the exact site of phosphorylation. Our experiments show that tagged may be purified from complex mixtures with extremely high specificity. Importantly, we found the sensitivity of the method to be sufficient for the recovery of picomole scale targets from milligrams of cell extract digest. This is a regime suitable for the identification of novel kinase substrates after their specific tagging by as-kinases in cell extracts. Application of this approach to the discovery of Cdk1-Cyclin B substrates in cell extracts yielded identification of over seventy substrates and phosphorylation sites. Many of these sites are known to be phosphorylated in vivo, but most of the proteins have not been previously characterized as Cdk1-Cyclin B substrates. This approach has the potential to expand our understanding of kinase-substrate connections in signaling networks.
Subcarrier-multiplexed four-dimensional LDPC coded modulation for high speed optical transmission systems (2010)

In this paper, we propose a subcarrier-multiplexed four-dimensional LDPC-coded modulation scheme suitable to achieve 400 Gb/s single-channel transmission rate over optical channels. The proposed scheme outperforms the corresponding polarization multiplexing schemes by up to 4.4 dB in OSNR at BER 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> .
High-Performance Affinity Monolith Chromatography:  Development and Evaluation of Human Serum Albumin Columns (2004)

Several immobilization methods were explored for the preparation of high-performance affinity monolithic columns containing human serum albumin (HSA). These monoliths were based on a copolymer of glycidyl methacrylate and ethylene dimethacrylate. In one method, the epoxy groups of this copolymer were used directly for the immobilization of HSA through its amine residues (i.e., the epoxy method); in other approaches, these epoxy groups were converted to diols for later use in the carbonyldiimidazole, disuccinimidyl carbonate, and Schiff base methods. Each HSA monolith was evaluated in terms of its total protein content and its retention of several model compounds, including (R/S)-warfarin and D/L-tryptophan. The greatest amount of immobilized HSA was obtained by the Schiff base method, whereas the epoxy method gave the lowest protein content. The Schiff base method also gave the best resolution in chiral separations of (R/S)-warfarin and D/L-tryptophan. All of the immobilization methods gave similar relative activities for HSA in its binding to (R)- and (S)-warfarin, but some differences were noted in the activity of the immobilized HSA for D- and L-tryptophan. The efficiency of these monoliths was found to be greater than that of silica-based HSA columns for (R/S)-warfarin (i.e., analytes with high retention), but little or no difference was seen for D- and L-tryptophan (analytes with weak retention).
Effect of nicotinamide mononucleotide on insulin secretion and gene expressions of PDX-1 and FoxO1 in RIN-m5f cells. (2011)

NMN can stimulate insulin secretion and upregulate the mRNA expression of PDX-1 in RIN-m5f cells.
Estudio de la fauna del nivel IV del Abrigo de la Quebrada y su aportación al conocimiento de la economía y el comportamiento humano en el Paleolítico Medio de la vertiente mediterránea ibérica. (2019)

Resumen: El Abrigo de la Quebrada (Chelva, Valencia) es un yacimiento con varios niveles de ocupacin del Paleoltico medio. El nivel IV, con dos dataciones de 43.930 750 BP (Beta-244002) y >51,6 ka BP (OxA-24855), se caracteriza por su estructura de palimpsesto y la elevada densidad de restos arqueolgicos (industria ltica, fauna, carbones y estructuras de combustin). El conjunto seo se compone de 100.907 restos, con una mayor presencia de las familias Bovidae, Equidae, Cervidae y Testudinidae. La presencia de fracturas frescas, muescas de percusin y marcas de corte confirma el carcter antrpico de la muestra, as como las termoalteraciones. Dada la elevada fragmentacin de la muestra (1% de identificados), se ha llevado a cabo tambin el anlisis de las esquirlas seas de <3cm, las cuales han reafirmado los datos del estudio arqueozoolgico y tafonmico de los restos identificados. El trabajo aporta nuevos datos econmicos en el marco del Paleoltico medio de la zona mediterrnea de la Pennsula ibrica.
CFTR-Mediated Cl<sup>−</sup>Transport in the Acinar and Duct Cells of Rabbit Lacrimal Gland (2012)

Our previous data showed the presence of CFTR in all acinar and duct cells within the rabbit LG, with expression most prominent in the apical membranes of duct cells. The present study demonstrates that CFTR is actively involved in Cl(-) transport in both acinar cells and epithelial cells from duct segments, suggesting that CFTR may play a significant role in LG secretion.
Synthesis and Antiviral Activity of Dimeric Capsid-Binding Inhibitors of Human Rhinovirus (HRV) (2004)

A set of dimeric analogues of known rhinovirus capsid-binders Pleconaril 1 and Pirodavir 55 has been synthesized and tested against two representative human rhinovirus (HRV) strains. Dimers with linker lengths ranging from five atoms up to approximately 60 atoms were prepared by coupling various functionalized monomeric precursors. Many of the dimers showed activity against HRV, with the most active compounds being those with the shorter linking groups. The lower activity of all the dimers relative to similar monomeric compounds, and especially the low activity of the longest dimers, suggests that cooperative bivalent binding is not occurring with any of these compounds.