gebhart/patrepeval huggingface dataset:
Links Between the Neurobiology of Oxytocin and Human Musicality (2020)

The human species possesses two complementary, yet distinct, universal communication systems-language and music. Functional imaging studies have revealed that some core elements of these two systems are processed in closely related brain regions, but there are also clear differences in brain circuitry that likely underlie differences in functionality. Music affects many aspects of human behavior, especially in encouraging prosocial interactions and promoting trust and cooperation within groups of culturally compatible but not necessarily genetically related individuals. Music, presumably <i>via</i> its impact on the limbic system, is also rewarding and motivating, and music can facilitate aspects of learning and memory. In this review these special characteristics of music are considered in light of recent research on the neuroscience of the peptide oxytocin, a hormone that has both peripheral and central actions, that plays a role in many complex human behaviors, and whose expression has recently been reported to be affected by music-related activities. I will first briefly discuss what is currently known about the peptide's physiological actions on neurons and its interactions with other neuromodulator systems, then summarize recent advances in our knowledge of the distribution of oxytocin and its receptor (OXTR) in the human brain. Next, the complex links between oxytocin and various social behaviors in humans are considered. First, how endogenous oxytocin levels relate to individual personality traits, and then how exogenous, intranasal application of oxytocin affects behaviors such as trust, empathy, reciprocity, group conformity, anxiety, and overall social decision making under different environmental conditions. It is argued that many of these characteristics of oxytocin biology closely mirror the diverse effects that music has on human cognition and emotion, providing a link to the important role music has played throughout human evolutionary history and helping to explain why music remains a special prosocial human asset. Finally, it is suggested that there is a potential synergy in combining oxytocin- and music-based strategies to improve general health and aid in the treatment of various neurological dysfunctions.
Associations between <i>meCP2 mutations, x‐chromosome inactivation, and phenotype</i> (2002)

Rett syndrome is a neurodevelopmental disorder of early postnatal brain growth in girls. Patients show a normal neonatal period with subsequent developmental regression and a loss of acquired skills (communication and motor skills), deceleration of head growth, and development of typical hand stereotypies. Recent studies have shown that mutations in the X-linked methyl CpG binding protein 2 gene (MeCP2) cause most typical cases of Rett syndrome. The MeCP2 gene encodes a protein that binds methylated cytosine residues of CpG dinucleotides and mediates, with histone deacetylases and transcriptional repressors, the transcription "silencing" of other genes. Girls with Rett syndrome exhibit mosaic expression for the MeCP2 defect at the cellular level, with most patients showing random X-inactivation and approximately equal numbers of cells expressing the normal MeCP2 gene and the mutated MeCP2 gene. In rare cases, females with a MeCP2 mutation escape phenotypic expression of the disorder because of nonrandom X-inactivation and the preferential inactivation of the mutated MeCP2 allele. Nonrandom patterns of X-inactivation may also contribute to the clinical variability often seen in girls with Rett syndrome. The spectrum of clinical phenotype caused by MeCP2 mutations is wide, including milder "preserved speech" variants, the severe congenital Rett variant, and a subset of X-linked recessive mental retardation in boys. Studies have shown that atypical and classical Rett syndrome can caused by the same MeCP2 mutations, indicating clinical phenotype is variable even among girls with the same MeCP2 mutation. The relationship between type of MeCP2 mutation, X-inactivation status, and clinical phenotype of Rett syndrome is complex and likely involves other environmental and polygenic modifiers.
The blood vessel recognition of ocular fundus (2005)

Today, iris recognition, fingerprint recognition, face recognition, voice recognition and other biometric technology are experiencing rapid development. This paper addresses a new biometric technology - skeleton recognition for blood vessel of optic fundus. The green grayscale ocular fundus image is utilized. The skeleton feature of blood vessel of optic fundus is extracted at first. After filtering treatment and extracting feature, vector curve of blood vessels is obtained. Shape curve matching is later carried out by means of reference point matching. The recognition for blood vessel optic fundus has been demonstrated in this paper to possess high recognition rate, low recognition rejection rate as well as good universality, exclusiveness and stability. With more and more progress made in extracting technology, the optic fundus blood vessel recognition is to become an effective biometric technology.
Qualitative Analysis for Students of Pharmacy and Medicine (Jordan, Charles B.) (1929)

ADVERTISEMENT RETURN TO ISSUEPREVBook and Media Revie...Book and Media ReviewNEXTQualitative Analysis for Students of Pharmacy and Medicine (Jordan, Charles B.)Lyman J. Wood Cite this: J. Chem. Educ. 1929, 6, 3, 593Publication Date (Print):March 1, 1929Publication History Received3 August 2009Published online1 March 1929Published inissue 1 March 1929https://doi.org/10.1021/ed006p593RIGHTS & PERMISSIONSArticle Views330Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Hydraulic Fracture Technology in the Ozona Canyon and Penn Sands (1996)

Abstract This paper details the acquisition and application of laboratory rock mechanical data, in situ stress measurements, dipole sonic logs, and pre- & post-fracture well test data to characterize hydraulic fracture performance in the Ozona Canyon and Penn sands, Ozona Field, Crockett County, Texas. The in situ stress measurements (micro-fracs) showed sand stresses from 0.55 to 0. 75 psi/ft, while shale stresses ranged from 0.8 to 0.85 psi/ft. These data were used to calibrate dipole sonic logs that ultimately resulted in lithology based (gamma-ray) stress profiles for fracture modeling studies. The variations in measured sand stresses using micro-frac tests indicated the need for small-volume water mini-fracs prior to many fracture treatments to measure local sand stresses. Excessive treating pressures (high net pressures) indicated the possibility of complex fracturing (or multiple fractures) and this interpretation was supported by the short "effective" fracture half-lengths (+/- 200 ft) calculated from subsequent fracture modeling and pre- & post-fracture well tests. The post-fracture well tests unexpectedly showed very low fracture conductivity that was also attributed to complex fracturing. The inability to significantly improve "effective" fracture length with increasing fluid & proppant volumes resulted in reduced treatment sizes (and treatment costs) and improved well economics.
Fecal S100A12 and fecal calprotectin as noninvasive markers for inflammatory bowel disease in children (2007)

Both fecal markers were superior to the sensitivities and specificities of any standard inflammatory test. Both fecal S100A12 and calprotectin are sensitive markers of gastrointestinal inflammation, but fecal S100A12 provided exceptional specificity in distinguishing children with IBD from children without IBD. Fecal S100A12 is a simple, noninvasive test that can be used to screen and select children warranting further invasive and laborious procedures such as endoscopy for the investigation of their gastrointestinal symptoms.
Effects of prebiotics on the immune response to vaccination in the elderly (2002)

No immunological effects of prebiotics were observed in this study.
A scalable, robust network for parallel computing (2001)

CX, a network-based computational exchange, is presented. The system's design integrates variations of ideas from other researchers, such as work stealing, non-blocking tasks, eager scheduling, and space-based coordination. The object-oriented API is simple, compact, and cleanly separates application logic from the logic that supports interprocess communication and fault tolerance. Computations, of course, run to completion in the presence of computational hosts that join and leave the ongoing computation. Such hosts, or producers, use task caching and prefetching to overlap computation with interprocessor communication. To break a potential task server bottleneck, a network of task servers is presented. Even though task servers are envisioned as reliable, the self-organizing, scalable network of n servers, described as a sibling-connected fat tree, tolerates a sequence of n — 1 server failures. Tasks are distributed throughout the server network via a simple “diffusion” process.
Query by tapping system based on alignment algorithm (2009)

Query-by-tapping systems are content-based music retrieval systems that allow users to tap or clap in a microphone the rhythmic pattern of the melody requested. In this paper, a new query-by-tapping system is described. This system is based on adaptations of alignment algorithms successfully applied for melodic similarity estimation. A similarity score is computed according to the cost of the elementary operations necessary to transform the query into the musical piece tested. A new method for extracting the rhythmic pattern from audio signals is also presented. This method is based on the analysis of the variations of the kurtosis computed from the audio samples. Experiments performed on the MIREX 2008 database show that the alignment technique proposed performs better than the participating algorithms. They also confirm the interest of the kurtosis-based analysis method in the case of noisy percussive queries.
Optical steering of high and low index microparticles by manipulating an off-axis optical vortex (2004)

We demonstrate the use of a rotating off-axis optical phase singularity, generated through an intentional misalignment of a high optical efficiency spiral phase plate (SPP), to optically steer both high and low index microparticles trapped within the optical beam in a controlled manner. This intentional misalignment of the SPP creates an asymmetrical intensity beam pattern due to the optical vortex being displaced from the centre of the beam propagation axis. By using this optical beam pattern, we propose that a cell can be trapped by an optical beam of matching beam diameter while its internal structure can be manipulated by the off-axis optical vortex.
Protein kinase CK2: a challenge to canons (2002)

CK2 is an extremely conserved pleiotropic protein kinase with a growing list of more than 300 substrates, the majority of which are proteins implicated in signal transduction, gene expression and other nuclear functions. The CK2 phosphoacceptor sites are specified by multiple acidic residues, with the one at position +3 relative to the target residue being of crucial relevance. The CK2 holoenzyme is composed of two catalytic subunits (alphaalpha, alpha'alpha' or alphaalpha'), which are essential for cell viability, and a dimer of two non-catalytic beta subunits, whose precise function is still poorly understood. Although the beta subunits deeply affect many properties of CK2, both the isolated catalytic subunits and the holoenzyme are constitutively active, which is probably responsible for the oncogenic potential of CK2. Given the structure of the holoenzyme, the beta subunits could undergo reversible dissociation under physiological conditions and play a role as anchoring elements and/or as a docking platform for protein substrates and effectors. These unusual features are likely to be instrumental in the involvement of CK2 in a number of key biological functions, notably RNA synthesis, Wnt signaling, ubiquitination and cell survival.
Antimicrobial Activity and Spectrum of Daptomycin Tested Against Gram-positive Strains Collected in European Hospitals: Results from 7 Years of Surveillance (2003-2009) (2011)

Results: DAP was very active against SA and CoNS (MIC 50/90 , 0.25/0.5 mg/L for both organisms) and its activity was not adversely influenced by OXA-R. MRSA varied from 1.3% in Sweden to as high as 61.3% in Portugal and 55.9% in Greece. MRSA exhibited high R rates to levofloxacin (88.7) and clindamycin (40.2%), and high S rates to DAP (MIC 50/90 , 0.25/0.5 mg/L; 100.0% S), linezolid (LZD; MIC 50/90 , 1/2 mg/L; 99.9% S), tigecycline (TIG; MIC 50/90 , 0.12/0.25 mg/L; >99.9% S) and VAN (MIC 50/90 , 1/1 mg/L; 100.0% S). All E. faecalis were S to DAP. VAN-R E. faecium (VREFM) was observed in 13 of 15 countries evaluated and was highest in Ireland (62.4%) and UK (44.2%). DAP (MIC 50/90 , 2/2 mg/L; 100.0% S), LZD (MIC 50/90 , 1/2 mg/L; 99.7% S) and TIG (MIC 50/90 , 0.06/0.12 mg/L; 99.5% S) were the most active agents tested against VREFM. VAN-S and -R ENT were equally S to DAP. DAP was also active against BHS (MIC 50/90 , 0.06/0.25 mg/L; 100.0% S), VGS (MIC 50/90 , 0.25/0.5 mg/L; 99.8% S) and SB (MIC 50/90 , 0.06/0.12 mg/L; 100.0% S).
Entanglement’s Benefit Survives an Entanglement-Breaking Channel (2013)

Entanglement is essential to many quantum information applications, but it is easily destroyed by quantum decoherence arising from interaction with the environment. We report the first experimental demonstration of an entanglement-based protocol that is resilient to loss and noise which destroy entanglement. Specifically, despite channel noise 8.3 dB beyond the threshold for entanglement breaking, eavesdropping-immune communication is achieved between Alice and Bob when an entangled source is used, but no such immunity is obtainable when their source is classical. The results prove that entanglement can be utilized beneficially in lossy and noisy situations, i.e., in practical scenarios.
Rapid Rail Mapping of Queensland Rail Central Line (1998)

A Rapid Rail Mapping System was used to provide coordinates and horizontal and vertical alignments of the track centreline as well as the positions of trackside features. RRMS utilises GPS and inertial measuring systems to provide the location of the measuring vehicle, and stereoscopic video imagery for the position of features. This paper describes the setup and use of this equipment, field operations for the collection of raw data, the methods of data reduction and the computations necessary to provide the required information. An analysis of the results is provided including suggestions for improvement.
Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate (1986)

The phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA), at concentrations of 0.1 microM and above, stimulated secretion of glucagon and of insulin from isolated rat islets of Langerhans incubated in the presence of 5.5 mM-glucose. Stimulation of secretion of both hormones by 1 microM-PMA persisted in the absence of external Ca2+, and could be abolished by incubating the islets at 4 degrees C. These findings suggest a role of protein kinase C in the alpha-cell (and beta-cell) secretory mechanism.
Stereoselective Coordination of <i>C</i><sub>5</sub>‐Symmetric Corannulene Derivatives with an Enantiomerically Pure [Rh<sup>I</sup>(nbd*)] Metal Complex (2011)

Catching the bowl! Enantiopure RhI dimethylnorbornadiene fragments selectively catch interconverting enantiomers of C5-sym-pentasubstituted corannulene derivatives in one bowl form and allow the observation and isolation of enantiopure metal-buckybowl complexes. A quantum mechanical model (see picture) predicts the mechanism of molecular dynamics and degree of stereoselective recognition. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Precise characterization and quantification of infantile spasms (1979)

Abstract With the use of a time‐synchronized video and polygraphic recording system, 5,042 infantile spasms were monitored and analyzed in 24 infants aged 1 to 43 months. Of these, 33.9% were flexor, 22.5% extensor, and 42.0% mixed flexor‐extensor. Sometimes the spasms were followed by a period of akinesia and diminished responsiveness lasting up to 90 seconds, and rarely (1.0%) this “arrest” effect constituted the entire seizure. More than one type of seizure occurred in 21 of the 24 infants. In the same number, 78.3% of the seizures occurred in clusters, and the intensity and frequency of the spasms in each cluster often increased to a peak, then progressively decreased until they stopped. Predominantly, the clusters occurred soon after arousal from sleep. The number of seizures occurring at night (55.2%) was similar to the diurnal number (44.8%). The electroencephalographic seizure pattern was variable, but a marked generalized attenuation of electrical activity was a feature of 71.7% of the attacks. Attenuation episodes of similar degree and duration occurred with no evidence of a seizure.
Fault Analysis and Debugging of Microservice Systems: Industrial Survey, Benchmark System, and Empirical Study (2018)

The complexity and dynamism of microservice systems pose unique challenges to a variety of software engineering tasks such as fault analysis and debugging. In spite of the prevalence and importance of microservices in industry, there is limited research on the fault analysis and debugging of microservice systems. To fill this gap, we conduct an industrial survey to learn typical faults of microservice systems, current practice of debugging, and the challenges faced by developers in practice. We then develop a medium-size benchmark microservice system (being the largest and most complex open source microservice system within our knowledge) and replicate 22 industrial fault cases on it. Based on the benchmark system and the replicated fault cases, we conduct an empirical study to investigate the effectiveness of existing industrial debugging practices and whether they can be further improved by introducing the state-of-the-art tracing and visualization techniques for distributed systems. The results show that the current industrial practices of microservice debugging can be improved by employing proper tracing and visualization techniques and strategies. Our findings also suggest that there is a strong need for more intelligent trace analysis and visualization, e.g., by combining trace visualization and improved fault localization, and employing data-driven and learning-based recommendation for guided visual exploration and comparison of traces.
Microbleeds in Late-Life Depression: Comparison of Early- and Late-Onset Depression (2014)

Late-life depression could be classified roughly as early-onset depression (EOD) and late-onset depression (LOD). LOD was proved to be associated with cerebral lesions including white matter hyperintensities (WMH) and silent brain infarctions (SBI), differently from EOD. However, it is unclear whether similar association is present between LOD and microbleeds which are also silent lesions. In this study, 195 patients of late-life depression were evaluated and divided into EOD, presenile-onset depression (POD), and LOD groups; 85 healthy elderly controls were enrolled as controls. Subjects were scanned by MRI including susceptibility weighted images to evaluate white matter hyperintensities (WMH), silent brain infarctions (SBI), and microbleeds. The severity of depression was evaluated with 15-item Geriatric Depression Scale. Psychosocial factors were investigated with Scale of Life Events and Lubben Social Network Scale. Logistic regression and linear regression were performed to identify the independent risk factors for depression. Results showed that LOD patients had higher prevalence of microbleeds than EOD, POD, and control patients. The prevalence of lobar microbleeds and microbleeds in the left hemisphere was the independent risk factor for the occurrence of LOD; a high number of microbleeds were associated with severe state of LOD, whereas life events and lack of social support were more important for EOD and POD. All these results indicated that Microbleeds especially lobar microbleeds and microbleeds in the left hemisphere were associated with LOD but not with EOD.
Humoral Immunity in Infants with Gastroenteritis Caused by Human Calicivirus (1985)

To assess the serum immune response in infants with gastroenteritis caused by human calicivirus (HCV), we tested a total of 165 serum specimens for antibodies to HCV by a radioimmunoassay blocking (RIA-BL) test. The specificity of the RIA-BL test for antibody to HCV was established as follows: paired sera from patients with HCV gastroenteritis revealed significant rises in antibody to HCV, whereas there was no significant change in RIA-BL titer to HCV in paired sera collected from the same individuals when infected with other gastroenteritis viruses. We analyzed 41 paired sera from patients and from healthy contacts involved in an outbreak of HCV gastroenteritis. All 23 infants without preexisting antibody revealed a sharp rise in HCV titer, and 18 (73%) of 23 of them developed illness. Fifteen of 18 infants with preexisting antibody also revealed a significant rise in HCV antibody, but only 3 (16.7%) of 18 became ill (P less than .01). These data suggest that the presence of serum antibody may correlate with resistance to illness in HCV gastroenteritis.
Alternative parameters of channel interactions. I. Symmetry analysis of the two-channel coupling (1984)

Translations of the scales of the Lu-Fano plots are introduced phenomenologically to bring out the symmetry of two-channel coupling. These shifts in the ( nu i) space amount to a phase renormalisation of the Coulomb basis wavefunctions of QDT, which eliminates the diagonal elements of Seaton's reactance matrix. The off-diagonal element of the resulting matrix measures the effective coupling strength and the new origins of the Lu-Fano plot axes mark the extrema of channel admixture. In the continuous energy range, the parameters ( mu i, xi ) provide a compact expression of the cross section for any two-channel (one open and one closed) process, including the whole series of resonances due to the discrete states in the closed channel. A similar generalisation of the Beutler-Fano resonance formula has been previously achieved by Dubau and Seaton (1984).