gebhart/patrepeval huggingface dataset:
Avulsion of lateral tibial condyle in skiing (1982)

The purpose of this article is to report four cases of avulsion of the lateral tibial condyle which occurred in one month of a skiing season at a large ski resort in West Virginia. This includes three women and one man who all complained of knee pain following ski injury and showed avulsion or "chip" fracture of the lateral tibial condyle on roentgenographic examination. Two of the injuries were associated with nonrelease of ski bindings. In all four cases the diagnosis of anterolateral rotary instability was not appreciated by the initial examiner, however, and the knee was treated with a splint. Avulsion fracture of the middle third of the lateral tibial condyle, the so called "lateral capsular sign," represents a serious ligamentous injury which results in significant knee instability. Surgical repair of this type of injury is generally recommended.
Abnormal Condensation of Piperidinium Acetate with Aromatic Aldehydes<sup>,a</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAbnormal Condensation of Piperidinium Acetate with Aromatic Aldehydes,aR. H. POIRIER, R. D. MORIN, ARVETA M. McKIM, and A. E. BEARSECite this: J. Org. Chem. 1961, 26, 11, 4275–4278Publication Date (Print):November 1, 1961Publication History Published online1 May 2002Published inissue 1 November 1961https://pubs.acs.org/doi/10.1021/jo01069a022https://doi.org/10.1021/jo01069a022research-articleACS PublicationsRequest reuse permissionsArticle Views506Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pilot-Scale Production of Fatty Acid Ethyl Esters by an Engineered <i>Escherichia coli</i> Strain Harboring the p(Microdiesel) Plasmid (2010)

Fatty acid ethyl esters (FAEEs) were produced in this study by the use of an engineered Escherichia coli p(Microdiesel) strain. Four fed-batch pilot scale cultivations were carried out by first using glycerol as sole carbon source for biomass production before glucose and oleic acid were added as carbon sources. Cultivations yielded a cell density of up to 61 +/- 3.1 g of cell dry mass (CDM) per liter and a maximal FAEE content of 25.4% +/- 1.1% (wt/wt) of CDM.
Measurement of Vertical Groundwater Velocity from Temperature Profiles in Wells (1971)

Vertically moving groundwater transports heat by convection and causes curvature in the earth's thermal profile. Dimensionless plots of the temperature distribution in wells can be matched with published type curves to obtain solutions for vertical groundwater velocity, if the thermal conductivity of the solid‐fluid complex is known or can be estimated. Rates of upward movement through semiconfining beds determined from temperature studies in the San Luis valley of Colorado and the Roswell basin of New Mexico were in good agreement with rates computed from pumping tests and water budget methods. Limitations of the method result from instability in borehole fluids, measurement detail required, and magnitudes of flow that can be detected.
Studies on Interferon Induction by Infectious Bursal Disease Virus (IBDV). II. Interferon Production in White Leghorn Chickens Infected with an Attenuated or Pathogenic Isolant of IBDV (1979)

J. Gelb, C. S. Eidson, O. J. Fletcher, S. H. Kleven, Studies on Interferon Induction by Infectious Bursal Disease Virus (IBDV). II. Interferon Production in White Leghorn Chickens Infected with an Attenuated or Pathogenic Isolant of IBDV, Avian Diseases, Vol. 23, No. 3 (Jul. - Sep., 1979), pp. 634-645
Synthesis of deuterium‐, tritium‐, and carbon‐14‐labeled BILN2061, a potent hepatitis C virus protease inhibitor (2005)

Abstract Hepatitis C virus (HCV) serine protease is a target for antiviral therapy against HCV infection, a leading cause of liver transplantation in the US. BILN2061, (1 S , 4 R , 6 S , 7 Z , 14 S , 18 R )‐14‐cyclopentyloxycarbonylamino‐18‐[2‐(2‐isopropylamino‐thiazol‐4‐yl)‐7‐methoxyquinolin‐4‐yloxy]‐2,15‐dioxo‐3,16‐diazatricyclo[14.3.0.0 4,6 ]nonadec‐7‐ene‐4‐carboxylic acid, is a potent inhibitor of HCV and the first compound in this class of cyclic peptides in human trials. Here, we report the synthesis of deuterium‐labeled BILN2061 with isotopic enrichment of 99%, tritium‐labeled BILN2061 with a specific activity of 17.1 GBq/mmol, and carbon‐14‐labeled BILN2061 with a specific activity of 1.83 GBq/mmol. The isotopes were incorporated via a Hantzsch thiazole synthesis of labeled isopropyl thiourea and α ‐bromoketone intermediate. The preparation of labeled isopropyl thiourea is reported. Copyright © 2005 John Wiley & Sons, Ltd.
Design of a micro-service based Data Pool for device integration to speed up digitalization (2019)

The integration of heterogeneous systems and devices from different technological generations demands an easy and seamless way to exchange information. Gateways are essential to ensure the interoperability and operation of complex integrated infrastructures. Additional features such as resilience, cybersecurity and scalability may be needed depending on the application. This paper presents an enhanced gateway (Data Pool) based on a micro-service architecture that enables message brokerage and device integration for Industrial IoT applications, fulfilling these requirements.
Firearm storage patterns in US homes with children (2000)

Many children live in homes with firearms that are stored in an accessible manner. Efforts to prevent children's access to firearms are needed.
Improving Service Performance through Object Replication in Middleware: A Peer-to-Peer Approach (2005)

The scalability of a distributed service can be improved if the number of replicated instances of the service can vary with the load experienced by the system. To ensure that the number and placement of the replicas can be dynamically changed based on network and load conditions, a peer node must know when it should create a new replica and when such a replica can be removed. A scheme that makes such decisions centrally suffers from a number of problems. In this paper, we propose a self-managing replication algorithm for a peer-to-peer system where a peer node makes its decisions based on its locally maintained information. This algorithm offers several benefits. They include being responsive to heterogeneous load and ensuring that each peer node fairly contributes its available resources to meet the needs of the overall system. It is evaluated with simulations of a system that consists of one thousand nodes. Our results show that this self-managing algorithm can maintain a replication degree that adapts to load in the system and achieve a low response time.
Effect of Repeated Verbal Stimulation upon a Flexor-Extensor Relationship (1958)

Previous work with psychiatric patients has indicated that repeated verbal stimulation, without induction of hypnotic trance, may produce definite — though transitory — personality changes. The purpose of the present investigation was to determine whether such repeated verbal stimulation would affect an objectively measurable physiological state. Accordingly, we chose to study flexor-extensor (biceps-triceps) dominance of the right upper arm. Several means designed to increase the effectiveness of repeated verbal stimulation were employed. Prior to verbal stimulation, electromyographic recordings were carried out in order to determine the amount and direction of dominance in the flexor-extensor relationship. In three of four patients, the prestimulation recordings revealed flexor dominance with only slight extensor dominance in the fourth patient. In all four cases a recorded statement to the effect that the right arm was extending was played repeatedly to the patient. Results showed that in all four cases there was a statistically significant shift in the direction of greater extensor dominance. Evidence was cited favoring the conclusion that the positive effects of repeated verbal stimulation were not simply produced by voluntary muscular contraction or posturing on the part of the patients. The relevance of present findings to problems in the field of psychosomatic medicine is suggested.
Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease (2008)

Background: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is a degradative process involving lysosomal turnover of cellular components, though its role in human diseases remains unclear.
Performance evaluation of the transversal filter equalizer using ZF and LMS algorithm (2002)

In practical digital communication systems, the equalizer in the receiver is generally used to compensate for the distortion induced from the communication channels. We construct a channel estimation model for a linear equalizer and evaluate the performance of the equalizer with the ZF (zero-forcing) and LMS (least mean square) algorithm using a specified channel characteristic. From the simulation results, both the ZF and LMS algorithm with 11 taps compensate perfectly the channel-induced distortion known as intersymbol interference.
Stability of synchronous intensity modulation control of 40-Gb/s dispersion-managed soliton transmissions (2001)

The efficiency of transmission control of dispersion-managed solitons by means of in-line synchronous intensity modulation is numerically analyzed. We demonstrate that intensity modulation may lead to dramatic improvements in the transmission performance of 40-Gb/s dispersion-managed solitons. In particular, we identify the locations within the dispersion map where synchronous intensity modulation provides an efficient control of the pulse propagation. Namely, a stabilization of pulse energy fluctuations is achieved, with no need for additional in-line control by guiding filters. On the other hand, incorrectly placed intensity modulation may cause significant pulse instabilities.
PS 1-5: The Functional Impact of HBV Integration into the Telomerase Reverse Transcriptase Promoter on Hepatocarcinogenesis (2016)

Aims: HBV integration into the cellular genome is frequently found in HCC and associated with genomic instability, leading to hepatocarcinogenesis. Telomerase-reverse transcriptase (TERT) promoter mutation was recently suggested to be gatekeeper in HCC.Interestingly, recent high-throughput DNA sequencing studies demonstrate that HBV integration is not random, with the highest frequency in telomere-related genes. The study aimed to investigate the molecular effect of HBV integration into the TERT promoter on hepatocarcinogenesis. Methods: Sixteen hepatoma/normal cell lines were sequenced for hTERT promoter mutation, followed by real-time RT-PCR for hTERT expression. Integration plasmid, pKT2C-HBx-TERTpmt-Luc containing HBx integrated into the various sites on hTERT promoter, was constructed and transfected into the cells. To generate genomic rearrangements associated with integration, HBx C-terminal truncation (aa27) and then hTERT hot spot mutation (-124C>T) were introduced in the HBx-hTERT fusion fragment by site-directed mutagenesis. The molecular functions of the HBx-hTERT integrants were examained by luciferase reporter and cell proliferation/apoptosis assays. Results: hTERT promoter mutation was detected in 7 (43.8%) of 16 cell lines. HCC cells with both HBV integration and hTERT promoter mutation showed a higher hTERT mRNA expression than those with either one alone or none. Although full-length HBx integration (Fl-HBx-TERT) exerts no or rather repressive effect on hTERT transcription, insertion of C-terminally truncated HBx (Tr-HBx-TERT) restored cis-activation of hTERT. The strongest effect was observed with further generation of hTERT promoter mutation (Tr-HBx-mt-TERT). Consistently, the HBx-hTERT integrants induced cell proliferation and inhibited apoptosis (caspases 3/7-dependent), with a general trend toward increasing effect from Fl-HBx-TERT to Tr-HBx-TERT and to Tr-HBx-mt-TERT. Conclusions: HBV integration can regulate the transcriptional activity of hTERT in cis and increase cell proliferation through anti-apoptotic actions, with a stronger oncogenic effect when HBx-truncation and hTERT promoter mutation are associated with integration. These findings provide insight into the implications of genomic rearrangements occurring at the viral-host junctions in integration-mediated hepatocarcinogenesis.
Highly textured La<sub>2</sub>Zr<sub>2</sub>O<sub>7</sub>buffer layers for YBCO-coated conductors prepared by chemical solution deposition (2005)

Recent results of La2Zr2O7 (LZO) buffer layer development for YBa2Cu3O7−x (YBCO-) coated conductors are presented. The major achievement is the development of a new precursor solution starting from 2,4-pentanedionates of lanthanum and zirconium leading to the formation of highly textured LZO buffer layers at low annealing temperatures. The preparation of the precursor solution using only a carboxylic acid as the solvent is simple and can be carried out at room temperature under atmospheric conditions. Reproducible highly textured buffer layers were obtained at annealing temperatures as low as 900 °C. The simplicity of the precursor solution preparation and the low annealing temperature (similar to the processing temperature of the YBCO layer) for preparation of an LZO buffer layer are the main advantages of this new process for cost-effective buffer layer deposition on Ni-RABiTS (rolling-assisted biaxially textured substrates).
Custom design of long chirped Bragg gratings: application to gain-flattening filter with incorporated dispersion compensation (2000)

We present and experimentally demonstrate simple relationships between the refractive index modulation, the chirp-rate or dispersion and the transmission loss through, and reflection of, chirped Bragg gratings, and apply them to the design of a new type of gain flattening filter with incorporated dispersion compensation.
Leistbarer Rechtsschutz aus Sicht des BVwG (2016)

Die Frage nach der Leistbarkeit des Rechtsschutzes umfasst mehrere Aspekte und kann einerseits unter dem Blickwinkel des unmittelbaren Zugangs der Bürgerinnen und Bürger zu einem unabhängigen und weisungsfreien Gericht betrachtet werden. Andererseits spielen in diesem Zusammenhang – aus staatlicher Sicht – budgetäre Rahmenbedingungen eine zentrale Rolle. Der im Rahmen des Forum Verwaltungsgerichtsbarkeit 2015 präsentierte Beitrag beleuchtet diese unterschiedlichen Aspekte aus Sicht des BVwG und gibt dabei gleichzeitig zahlreiche Einblicke in die Praxis des größten Verwaltungsgerichts Österreichs.
High resolution subpixel and subframe rendering for color flatpanel and projector displays (2011)

The heightened interest by the consumers on color flatpanel and projector displays is evidenced by the excitement surrounding LCD display in smartphones, color e-papers, and pico projectors. In this paper, we provide a new foundation for designing high fidelity displays in novel formfactors. We introduce a rendering error cancellation embedding technique that will increase the spatial resolution in color flatpanels without making changes to the display hardware. It makes subpixel “upsampling” in flatpanel displays almost unnecessary; and eliminate rainbow artifacts in single-chip projector displays.
Hough transform implementation on a reconfigurable highly parallel architecture (2002)

A highly parallel hardware architecture for Hough Transform (HT)-based parametric curve and end-points extraction is described. It's based on CAM (Content Addressable Memory) concept. Through using advanced VLSI technology, to classical CAM implementations, three main features are provided: Parallel write, parallel search and single/multi hit response flag. Moreover the high number of CAM words available per chip synchronized with a high frequency clock has the merit to keep low both the hardware amount and the execution time, while featuring the ability to extract efficiently curve parameters and their corresponding end-points. To evaluate its performance, experimental results for segment extraction are presented: By using two CAM chips, segment extraction of an image 256/spl times/256 is achieved in real-time.
Fertilizers grow: Heavy grades to polymers (1997)

Basic fibroblast growth factor (FGF-2) expression takes place during morphogenic differentiation of mammary ducts and is lost in breast cancer. Forced re-expression of FGF-2 in breast cancer cell lines induces a more differentiated phenotype and inhibits motility by unknown mechanisms. Here we demonstrate that MDA-MB-231 cells with encumbered motility due to forced re-expression of FGF-2 have activated focal complexes as determined by immunoprecipitation/western blotting and immunofluorescence staining with antibodies to FAK, p130Cas, paxillin, vinculin and phosphotyrosine. The activation of the focal adhesion complexes results in loss of stress fibers associated with malignant transformation of mammary epithelial cells and the formation of circumferentially-distributed actin bundles associated with non-transformed mammary epithelial cells. These effects require continuous FGF-2 expression, as the effects of exogenous recombinant FGF-2 are only small and transient. FGF-2 expression results in an increase in integrin alpha 3 expression and decreases in integrin beta 1 and beta 4 expression. These changes, however, induce only a small decrease in adhesion to uncoated and fibronectin-coated tissue culture dishes suggesting that the primary cause of impaired motility is due to intrinsic signaling. These data suggest that FGF-2-inhibits motility in breast cancer cells by stabilization of focal complexes and induction of a more differentiated phenotype with disruption of stress fiber formation and a characteristic cortical actin distribution.
Evaluation of body composition as a potential biomarker in spinal muscular atrophy (2020)

BC shows promise as a potential biomarker for SMA, but further studies are needed.
Enantioselective Allylation of Aldehydes Using Tartrate Ester Modified Allylsilanes (1997)

Abstract Tartrate-ester modified allylsilanes, 2-allyl-1,3,2-dioxasilolane-4,5-dicarboxylic esters, (1), were found to serve as useful reagents for regiospecific and stereoselecive allylation of aldehydes. Reactions of 1 with achiral aldehydes without any catalyst gave the corresponding homoallyl alcohols in good yields (70-90%) with the ee values up to 80%.
The Electron Cyclotron Maser—An Historical Survey (1976)

It has taken nearly twenty years for practical development of the electron cyclotron maser. The initial theoretical notions were understood by R. Q. Twiss in 1957, but the first clear experimental demonstration did not occur until 1964. Today, in the Soviet Union, these devices are being built which deliver kilowatt level cw power at submillimeter wavelengths, with high efficiency. This paper traces these developments, particularily during the first decade; after this Western activities in this field became rather somnolent, as the initiative passed to the Soviet scientists.
Phytochemical and Cytotoxic Investigations of Curcuma mangga Rhizomes (2011)

Investigations on the cytotoxic effects of the crude methanol and fractionated extracts (hexane, ethyl acetate) C. mangga against six human cancer cell lines, namely the hormone-dependent breast cell line (MCF-7), nasopharyngeal epidermoid cell line (KB), lung cell line (A549), cervical cell line (Ca Ski), colon cell lines (HCT 116 and HT-29), and one non-cancer human fibroblast cell line (MRC-5) were conducted using an in-vitro neutral red cytotoxicity assay. The crude methanol and fractionated extracts (hexane and ethyl acetate) displayed good cytotoxic effects against MCF-7, KB, A549, Ca Ski and HT-29 cell lines, but exerted no damage on the MRC-5 line. Chemical investigation from the hexane and ethyl acetate fractions resulted in the isolation of seven pure compounds, namely (E)-labda-8(17),12-dien-15,16-dial (1), (E)-15,16-bisnor-labda-8(17),11-dien-13-on (2), zerumin A (3), β-sitosterol, curcumin, demethoxycurcumin and bis-demethoxycurcumin. Compounds 1 and 3 exhibited high cytotoxic effects against all six selected cancer cell lines, while compounds 2 showed no anti-proliferative activity on the tested cell lines. Compound 1 also demonstrated strong cytotoxicity against the normal cell line MRC-5. This paper reports for the first time the cytotoxic activities of C. mangga extracts on KB, A549, Ca Ski, HT-29 and MRC-5, and the occurrence of compound 2 and 3 in C. mangga.
Inter‐bacterial correlations in subgingival biofilms: a large‐scale survey (2013)

Knowledge on bacterial correlations can pave the way for new treatment options focusing on restoring the shifted balance.
Liquid-liquid extraction equipment (1994)

Partial table of contents: Historical Background (M. Hampe, et al.). Recommended Systems for Liquid Extraction Studies (H.-J. Bart, et al.). Rate Coefficients in Liquid-Liquid Extraction Systems (M. Slater). General Hydrodynamic Design Basis for Columns (T. Misek). Computational Procedures for Column Simulation and Design (L. Steiner). Population Balance Based Modelling of Solvent Extraction Columns (C. Gourdon, et al.). Packed Columns (G. Stevens). Rotating Disc Contactors (W. Korchinsky). Pulsed Sieve-Plate Columns (H. Haverland & M. Slater). Mixers (J. Godfrey). Gravity Settlers (S. Hartland & S. Jeelani). Centrifugal Extractors (E. Blass). Index.
An Electronic Ballast With High Power Factor and Low Voltage Stress (2005)

This paper presents a new configuration for an electronic ballast with high power factor for fluorescent lamps. The proposed ballast consists of the integration of a buck-boost converter, used as an input stage to correct the power factor and regulate the voltage on a dc bus, and a resonant half-bridge inverter to drive the lamp. The buck-boost converter operates at a constant frequency and constant duty cycle in a discontinuous conduction mode during all input cycles.
Interface Stability of Argyrodite Li<sub>6</sub>PS<sub>5</sub>Cl toward LiCoO<sub>2</sub>, LiNi<sub>1/3</sub>Co<sub>1/3</sub>Mn<sub>1/3</sub>O<sub>2</sub>, and LiMn<sub>2</sub>O<sub>4</sub> in Bulk All-Solid-State Batteries (2017)

Argyrodite Li6PS5Cl is a good candidate for being a solid electrolyte for bulk all-solid-state Li-ion batteries because of its high ionic conductivity and its good processability. However, the interface stability of sulfide-based electrolytes toward active materials (negative or positive electrodes) is known to be lower than that of oxide-based electrolytes. In this work, we investigate the interface stability of argyrodite toward several positive electrode materials: LiCoO2, LiNi1/3Co1/3Mn1/3O2, and LiMn2O4. All-solid-state half-cells were cycled, and the interface mechanisms were characterized by Auger electron spectroscopy and X-ray photoelectron spectroscopy. We show that Li6PS5Cl is oxidized into elemental sulfur, lithium polysulfides, P2Sx (x ≥ 5), phosphates, and LiCl at the interface with the positive electrode active materials. In spite of this interface reactivity, good capacity retention was observed over 300 cycles. Li6PS5Cl shows some reversible electrochemical activity (redox processes) that might contribute to the reversible capacity of the battery.