gebhart/patrepeval huggingface dataset:
Evaluation of the Properties of Polystyrene Divinylbenzene Adsorbents for Debittering Grapefruit Juice (1990)

ABSTRACT Various physical properties of polystyrene divinylbenzene adsorbents involved in the removal of the bitter compounds naringin and limonin from grapefruit juice were investigated in a series of batch reaction processes. The removal of naringin from model systems and, naringin and limonin from grapefruit juice increased with the degree of cross‐linkage and surface area of the adsorbents which had a solid density higher than 1.2 g/mL (dry) to ensure complete submersion. The specific surface area appeared to be the major factor in the debittering process. Regeneration with 95% ethanol was found to be more efficient than warm water. Sensory evaluation tests showed that more than 65% of the panelists preferred the less bitter treated juice over the control.
Is the light emitting diode (LED) an ultimate lamp? (2000)

Simple diagrams are used to show the transformation of a thin “slab” of intrinsic semiconductor (direct gap, kelec=khole) from an ideal “flat-band” photopumped recombination-radiation light source into an ultimate lamp, a p–n junction light emitting diode (LED). A photoexcited intrinsic slab of semiconductor can be regarded as an ideal (“flat-band”) light source, with, however, the photogenerated carriers and voltage available externally instead of as recombination radiation (light) if the slab is converted to half p type (one side) and half n type (the other side), i.e., to a p–n junction. If an equal, a “bucking,” external voltage is applied, resulting in an input current when the photoexcitation is removed, the slab becomes again (remains) an ideal “flat-band” light source, a p–n junction LED. In practice, the LED takes the form of a p–n heterostructure in order to improve electron–hole injection, reduce the absorption of recombination radiation, and to make possible—with proper geometries—improved photon escape.
TCP Nice: Self-tuning Network Support for Background Applications (2002)

Many distributed applications can make use of large background transfers transfers of data that humans are not waiting for to improve availability, reliability, latency or consistency. However, given the rapid fluctuations of available network bandwidth and changing resource costs due to technology trends, hand tuning the aggressiveness of background transfers risks (1) complicating applications, (2) being too aggressive and interfering with other applications, and (3) being too timid and not gaining the benefits of background transfers. Our goal is for the operating system to manage network resources in order to provide a simple abstraction of near zero-cost background transfers. Our system, TCP Nice, can provably bound the interference inflicted by background flows on foreground flows in a restricted network model. And our microbenchmarks and case study applications suggest that in practice it interferes little with foreground flows, reaps a large fraction of spare network bandwidth, and simplifies application construction and deployment. For example, in our prefetching case study application, aggressive prefetching improves demand performance by a factor of three when Nice manages resources; but the same prefetching hurts demand performance by a factor of six under standard network congestion control.
Sequential Multiplex Analyte Capturing for Phosphoprotein Profiling (2010)

Microarray-based sandwich immunoassays can simultaneously detect dozens of proteins. However, their use in quantifying large numbers of proteins is hampered by cross-reactivity and incompatibilities caused by the immunoassays themselves. Sequential multiplex analyte capturing addresses these problems by repeatedly probing the same sample with different sets of antibody-coated, magnetic suspension bead arrays. As a miniaturized immunoassay format, suspension bead array-based assays fulfill the criteria of the ambient analyte theory, and our experiments reveal that the analyte concentrations are not significantly changed. The value of sequential multiplex analyte capturing was demonstrated by probing tumor cell line lysates for the abundance of seven different receptor tyrosine kinases and their degree of phosphorylation and by measuring the complex phosphorylation pattern of the epidermal growth factor receptor in the same sample from the same cavity.
Open-Hole Horizontal Drilling and Gravel-Packing With Oil-Based Fluids - An Industry Milestone (2004)

Abstract An increasing number of horizontal wells requiring sand control are being gravel packed, particularly in deep-water and/or sub-sea environments, where completion reliability is paramount due to prohibitively high cost of remediation. Tophole sections in many of these wells are being drilled with oilbased fluids, with the common practice of switching to waterbased fluids when the reservoir drilling starts. In the last several years, some operators started using oil-based drilling fluids in the reservoir section as well, and gravel packed them with water-based fluids. In some cases, these practices required running pre-drilled liners in oil-based fluids, and subsequently displacing to water-based fluids, prior to running in hole with the sand-face screens and gravel packing. In other instances, screens could be run in hole with oil-based fluids in the wellbore, and gravel packing could be performed with water-based fluids. In both cases, the presence of reactive shales and/or water-sensitive productive zone can introduce serious concern in the event that the carrier fluid losses occur into the formation during gravel packing. Although a base-oil or diesel can be used as a carrier fluid, low density of the base oil limits such applications to low-pressure/depleted wells. In this paper, we present a case history of the first successful application of drilling and completing in an all oil environment, utilizing a reversible oil-based reservoir drilling fluid and an oil-based gravel packing fluid. The carrier fluid used in this application included a filtercake cleanup solution in the aqueous internal phase of the oil-based carrier fluid, extending the application of simultaneous gravel packing and cake cleanup processes that have been successfully practiced in water-based fluid environments, to oil-based systems. The subject application was in a high-rate gas field located offshore Trinidad, with anticipated production rates in excess of 150 MMSCFD per well. Presented in the paper is the drilling and completion selection methodology based on extensive laboratory and yard testing, along with the details of the completion and recommendations for future applications based on lessons learned. A direct comparison of the all-oil drilling and completion process to water-based drilling and completion is also presented based on a case history from the same field.
Bird–building collisions in the United States: Estimates of annual mortality and species vulnerability (2014)

Abstract Building collisions, and particularly collisions with windows, are a major anthropogenic threat to birds, with rough estimates of between 100 million and 1 billion birds killed annually in the United States. However, no current U.S. estimates are based on systematic analysis of multiple data sources. We reviewed the published literature and acquired unpublished datasets to systematically quantify bird–building collision mortality and species-specific vulnerability. Based on 23 studies, we estimate that between 365 and 988 million birds (median = 599 million) are killed annually by building collisions in the U.S., with roughly 56% of mortality at low-rises, 44% at residences, and &lt;1% at high-rises. Based on &gt;92,000 fatality records, and after controlling for population abundance and range overlap with study sites, we identified several species that are disproportionately vulnerable to collisions at all building types. In addition, several species listed as national Birds of Conservation Concern due to their declining populations were identified to be highly vulnerable to building collisions, including Golden-winged Warbler (Vermivora chrysoptera), Painted Bunting (Passerina ciris), Canada Warbler (Cardellina canadensis), Wood Thrush (Hylocichla mustelina), Kentucky Warbler (Geothlypis formosa), and Worm-eating Warbler (Helmitheros vermivorum). The identification of these five migratory species with geographic ranges limited to eastern and central North America reflects seasonal and regional biases in the currently available building-collision data. Most sampling has occurred during migration and in the eastern U.S. Further research across seasons and in underrepresented regions is needed to reduce this bias. Nonetheless, we provide quantitative evidence to support the conclusion that building collisions are second only to feral and free-ranging pet cats, which are estimated to kill roughly four times as many birds each year, as the largest source of direct human-caused mortality for U.S. birds.
Single‐Step Reverse Transcription‐Polymerase Chain Reaction for the Detection of Hepatitis C Virus RNA (1998)

We developed a novel single-step reverse transcription-polymerase chain reaction (RT-PCR), which is equal in sensitivity and specificity to RT-nested PCR, based on both reverse transcriptase and Taq DNA polymerase working efficiently under single buffer reaction conditions. Using in vitro synthesized hepatitis C virus (HCV) RNA, it was demonstrated that 10-100 copies of HCV RNA could be detected with a set of primers that amplify a 144 base-pair sequence unique to the 5'-noncoding region of HCV RNA. Furthermore, this method was successfully performed on serum and liver biopsy specimens obtained from patients with chronic hepatitis C. In addition, HCV RNA from in vitro HCV-infected MT-2C cells, which supported HCV replication, was also detected by this method. The method is anticipated to improve the detection of small amounts of RNA, such as that of HCV, promoting both labor savings and the prevention of carry-over contamination.
Switchable Optical Frequency Comb in Aluminum Nitride Microring Resonator (2014)

Aluminum nitride is a promising nonlinear optical material with its strong Kerr and Pockels effects. Here we report optical frequency comb generation from aluminum nitride microring resonators and electrical switching of the comb.
A theoretical investigation of the rectangular microstrip antenna element (1978)

A theoretical treatment of the rectangular microstrip radiating element has been performed. The element has been modeled as a line resonator with radiation taking place at the open-circuited ends. This has been verified by using a liquid crystal visual detector. With the simplified model, the input impedance and the far fields have been calculated for different resonant modes. The interaction between the radiating ends will effect the input impedance, and this has been considered by defining a mutual conductance. Also, a mutual conductance between microstrip elements has been expressed in far-field quantities and plotted as a function of spacing along the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</tex> - and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</tex> - planes. The directivity of an isolated element has been calculated as the directivity of one radiating end times the contribution due to the array factor.
Solid phase synthesis of 2,3-dihydro-4-pyridones: Reaction of Danishefsky's diene with polymer-bound imines (1997)

An efficient method for the construction of 2,3-dihydro-4-pyridones on solid support has been developed, which utilized the Lewis-acid catalyzed tandem Mannich-Michael reaction of Danishefsky's diene with polymer-bound aldimines.
A new composite criterion for adaptive and iterative blind source separation (2002)

When n independent random signals are mixed by an unknown m/spl times/n matrix, the task of recovering the original signals from their mixtures is called blind source separation. The article introduces two simple source separation algorithms. The first one is adaptive, the second is iterative. Both work indifferently with complex or real signals and use an estimation equation involving 2nd-order and higher-order information. A key feature is that resulting performance is independent of the mixing matrix in the noiseless case. Simulations also indicate the absence of ill convergence.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Exacerbation of Thyroid Autoimmunity by Interferon .ALPHA. Treatment in Patients with Chronic Viral Hepatitis: Our Studies and Review of the Literature. (1994)

In the present studies, the long term effects of IFN alpha on thyroid function and thyroid autoantibodies were evaluated in 42 patients with chronic viral hepatitis type C treated with IFN alpha for at least 4 months. Before IFN treatment, 41 patients tested were all euthyroid. Five (12%) out of 24 patients tested had positive tests for thyroid autoantibodies. MCHA/TPOAb was detected in all 5 and TGHA/TGAb in 3 out of these 5 patients. Six to 10 x 10(6) units (U) of recombinant or natural IFN alpha were given intramuscularly daily for the first 2 to 4 weeks, followed by 3 to 10 x 10(6) U thrice weekly for the subsequent 14 to 22 weeks. Thyroid dysfunction and/or rises in titers of thyroid autoantibodies were observed in 6 patients during IFN alpha treatment; clinically overt thyroid dysfunctions, destructive thyroiditis and thyrotoxicosis of unidentified etiology, developed in 2 patients 4 to 5 months after start of IFN treatment, subclinical hypothyroidism with a slight increase in serum TSH concentrations but no serum thyroid hormone alternations was observed in 2 patients, and increases in titers of thyroid autoantibodies without thyroid dysfunction were found in 2 patients. Thus, IFN alpha exacerbated thyroid autoimmunity exclusively in all patients with positive tests for thyroid autoantibodies prior to treatment, but did not induce thyroid autoimmunity in thyroid autoantibody-negative patients. These data suggest that the prolonged IFN alpha therapy can lead to exacerbation of thyroid autoimmunity in susceptible (thyroid autoantibody-positive) patients.
High-Throughput Genotyping of Green Algal Mutants Reveals Random Distribution of Mutagenic Insertion Sites and Endonucleolytic Cleavage of Transforming DNA (2014)

A high-throughput genetic screening platform in a single-celled photosynthetic eukaryote would be a transformative addition to the plant biology toolbox. Here, we present ChlaMmeSeq (Chlamydomonas MmeI-based insertion site Sequencing), a tool for simultaneous mapping of tens of thousands of mutagenic insertion sites in the eukaryotic unicellular green alga Chlamydomonas reinhardtii. We first validated ChlaMmeSeq by in-depth characterization of individual insertion sites. We then applied ChlaMmeSeq to a mutant pool and mapped 11,478 insertions, covering 39% of annotated protein coding genes. We observe that insertions are distributed in a manner largely indistinguishable from random, indicating that mutants in nearly all genes can be obtained efficiently. The data reveal that sequence-specific endonucleolytic activities cleave the transforming DNA and allow us to propose a simple model to explain the origin of the poorly understood exogenous sequences that sometimes surround insertion sites. ChlaMmeSeq is quantitatively reproducible, enabling its use for pooled enrichment screens and for the generation of indexed mutant libraries. Additionally, ChlaMmeSeq allows genotyping of hits from Chlamydomonas screens on an unprecedented scale, opening the door to comprehensive identification of genes with roles in photosynthesis, algal lipid metabolism, the algal carbon-concentrating mechanism, phototaxis, the biogenesis and function of cilia, and other processes for which C. reinhardtii is a leading model system.
Optimization of Medium Composition for Biomass Production of<i>Lactobacillus plantarum</i>200655 Using Response Surface Methodology (2021)

This study aimed to optimize medium composition and culture conditions for enhancing the biomass of <i>Lactobacillus plantarum</i> 200655 using statistical methods. The one-factor-at-a-time (OFAT) method was used to screen the six carbon sources (glucose, sucrose, maltose, fructose, lactose, and galactose) and six nitrogen sources (peptone, tryptone, soytone, yeast extract, beef extract, and malt extract). Based on the OFAT results, six factors were selected for the Plackett- Burman design (PBD) to evaluate whether the variables had significant effects on the biomass. Maltose, yeast extract, and soytone were assessed as critical factors and therefore applied to response surface methodology (RSM). The optimal medium composition by RSM was composed of 31.29 g/l maltose, 30.27 g/l yeast extract, 39.43 g/l soytone, 5 g/l sodium acetate, 2 g/l K<sub>2</sub>HPO<sub>4</sub>, 1 g/l Tween 80, 0.1 g/l MgSO<sub>4</sub>·7H<sub>2</sub>O, and 0.05 g/l MnSO<sub>4</sub>·H<sub>2</sub>O, and the maximum biomass was predicted to be 3.951 g/l. Under the optimized medium, the biomass of <i>L. plantarum</i> 200655 was 3.845 g/l, which was similar to the predicted value and 1.58-fold higher than that of the unoptimized medium (2.429 g/l). Furthermore, the biomass increased to 4.505 g/l under optimized cultivation conditions. For lab-scale bioreactor validation, batch fermentation was conducted with a 5-L bioreactor containing 3.5 L of optimized medium. As a result, the highest yield of biomass (5.866 g/l) was obtained after 18 h of incubation at 30°C, pH 6.5, and 200 rpm. In conclusion, mass production by <i>L. plantarum</i> 200655 could be enhanced to obtain higher yields than that in MRS medium.
Das Politische in der transnationalen Welt (2000)

Globalisiemng ist an der Wende zum einundzwanzigsten lahrhundert in wichtigen Handlungsbereichen eine Tatsache. Am offenkundigsten ist dies im Bereich der Kommunikation. Was an dem einen Ende der Welt geschieht, geht in Echtzeit als Fernsehbild mnd urn die Welt und kann liberall wahrgenommen werden. Die Vision Me Luhan’s yom Globalen Dorf, das die neuen Kommunikationsmittel unvermeidlich herbeiführen, ist im Großen und Ganzen heute Wirklichkeit geworden. Kommunikationsinseln, etwa wenn ein Land von den Informationsstöomen der Welt klinstlich abgeschottet werden soIl, lassen sich im Zeitalter von Internet und Satelliten-Fernsehen nicht mehr für längere Zeit aufrechterhalten.
Photophysics and Release Kinetics of Enzyme-Activatable Optical Probes Based on H-Dimerized Fluorophores on Self-Immolative Linkers (2013)

A series of activatable optical probes for the model enzyme penicillin G amidase based on intramolecular formation of non-fluorescent H-dimer between two identical dyes were synthesized. The probes are based on a self-immolative linker, which allows positioning both dyes in close spatial proximity to ensure efficient quenching of probes with absorption and fluorescence emission in the near-infrared (NIR) range. A detailed photophysical investigation of the novel optical probes led to a revision of a previously anticipated quenching mechanism and revealed their potential for optimizing the performance of activatable probes based on H-dimer formation. A kinetic analysis indicated that the fluorescence progress curves can be used to qualitatively extract enzyme kinetic parameters.
Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE (2003)

Abstract Interaction of very late antigen-4 (VLA-4) with its ligand vascular cell adhesion molecule-1 (VCAM-1) is required for central nervous system (CNS) migration of encephalitogenic T cells in relapsing experimental autoimmune encephalomyelitis (R-EAE). Anti-VLA-4 monoclonal antibody (mAb) treatment prior to EAE onset inhibits disease induction; however, treatment initiated after the appearance of clinical symptoms increases relapse rates, augments Th1 responses, and enhances epitope spreading perhaps due to the activation of costimulatory signals. To negate the potential costimulatory activity of intact anti-VLA-4, we examined the ability of BIO 5192, a small-molecule VLA-4 antagonist, to regulate active proteolipid protein 139-151 (PLP139-151)-induced R-EAE. BIO 5192 administered one week after peptide priming (ie, before clinical disease onset) delayed the clinical disease onset but led to severe disease exacerbation upon treatment removal. BIO 5192 treatment initiated during disease remission moderately enhanced clinical disease while mice were on treatment and also resulted in posttreatment exacerbation. Interestingly, BIO 5192 treatment begun at the peak of acute disease accelerated entrance into disease remission and inhibited relapses, but treatment removal again exacerbated disease. Enhanced disease was caused by the release of encephalitogenic cells from the periphery and the rapid accumulation of T cells in the CNS. Collectively, these results further demonstrate the complexity of VLA-4/VCAM interactions, particularly in a relapsing-remitting autoimmune disease. (Blood. 2003;102:4464-4471)
Wavelet based denoising techniques for ultrasound images (2002)

Clinical research has shown a clear correlation between white matter disorders of the neonatal brain and neuro-motoric handicap at a later age. The visual interpretation of ultrasound images is a proven method to detect white matter damage at in early stage. A problem, common to all medical ultrasound images, is the presence of speckle noise, which not only complicates the visual interpretation of images, but also the quantitative measurements. In this article we compare two wavelet based filtering methods which are applied in order to remove speckle noise and preserve details as well. The first one is a new wavelet-based method for image denoising that applies the Bayesian framework, using prior knowledge about the spatial clustering of the wavelet coefficients. Local spatial interactions of the wavelet coefficients are modeled by adopting a Markov random field model. The second one is a new filtering method, based on a recursive filtering of detail images obtained from a wavelet decomposition of the image by using spatial filtering which is based on threshold decomposition and simple spatial rules.
High-dose cisplatin with sodium thiosulfate protection. (1985)

Nephrotoxicity frequently limits the dose of cisplatin to less than 120 mg/m2 per injection. Sodium thiosulfate is a neutralizing agent for cisplatin that protects against renal damage. To determine whether injection of thiosulfate would permit larger doses of cisplatin to be administered, a fixed 9.9-g/m2 dose of thiosulfate was given intravenously over three hours concurrently with escalating doses of cisplatin. Cisplatin was administered over the last two hours of the thiosulfate infusion. Using this technique, it was possible to escalate the cisplatin dose to 225 mg/m2 before dose-limiting toxicities were encountered. Comparison of cisplatin pharmacokinetics in patients treated with 202.5 mg/m2 plus thiosulfate to those in patients treated with 100 mg/m2 without thiosulfate indicated that there were no changes in the elimination rate constant, volume of distribution, or total body clearance of cisplatin. The total drug exposure for the plasma was approximately twofold at the higher cisplatin dose. This study demonstrates that concurrent administration of thiosulfate permits at least a twofold increase in dose and total exposure to cisplatin.