gebhart/patrepeval huggingface dataset:
A Markov Decision Model and Decomposition Heuristic for Dynamic Vehicle Dispatching (1993)

We describe a dynamic and stochastic vehicle dispatching problem called the delivery dispatching problem. This problem is modeled as a Markov decision process. Because exact solution of this model is impractical, we adopt a heuristic approach for handling the problem. The heuristic is based in part on a decomposition of the problem by customer, where customer subproblems generate penalty functions that are applied in a master dispatching problem. We describe how to compute bounds on the algorithm's performance, and apply it to several examples with good results.
Recent Trends in Lower-Limb Robotic Rehabilitation Orthosis: Control Scheme and Strategy for Pneumatic Muscle Actuated Gait Trainers (2014)

It is a general assumption that pneumatic muscle-type actuators will play an important role in the development of an assistive rehabilitation robotics system. In the last decade, the development of a pneumatic muscle actuated lower-limb leg orthosis has been rather slow compared to other types of actuated leg orthoses that use AC motors, DC motors, pneumatic cylinders, linear actuators, series elastic actuators (SEA) and brushless servomotors. However, recent years have shown that the interest in this field has grown exponentially, mainly due to the demand for a more compliant and interactive human-robotics system. This paper presents a survey of existing lower-limb leg orthoses for rehabilitation, which implement pneumatic muscle-type actuators, such as McKibben artificial muscles, rubbertuators, air muscles, pneumatic artificial muscles (PAM) or pneumatic muscle actuators (PMA). It reviews all the currently existing lower-limb rehabilitation orthosis systems in terms of comparison and evaluation of the design, as well as the control scheme and strategy, with the aim of clarifying the current and on-going research in the lower-limb robotic rehabilitation field.
Clearance of sensitized erythrocytes in NZB/NZW mice Effects of castration and sex hormone treatment (1981)

The clearance of particulate immune complexes consisting of erythrocytes sensitized with IgG or complement was investigated in (NZB x NZW)F1 (B/W) mice. Treatment of castrated B/W mice with androgen or estrogen was able to modulate this clearance. Young (3-month-old) male and female B/W mice cleared IgG-sensitized mouse erythrocytes rapidly, whereas older males (13 months) and females (7 months) showed a marked impairment in their ability to clear these cells. In addition, erythrocytes sensitized with complement in the absence of antibody were cleared within 5 min in young B/W mice. Older mice showed a greater and more rapid clearance rate of these cells. Castrated female B/W mice treated with androgen implants from three weeks of age showed improved clearance of IgG-sensitized erythrocytes at 7 months, whereas estrogen-treated male mice showed delayed clearance. These results suggest an age-dependent defect in the clearance of IgG-sensitized particles, perhaps due to diminished levels of serum complement and/or saturation of Fc receptors. In addition, there is an alteration in the clearance of complement-sensitized erythrocytes which may be related to changes in macrophage activity or enzyme inactivators of C3 and C4. The possible mechanisms responsible for the hormonal modulation of clearance are discussed in relation to the known ability of these hormones to influence autoimmune diseases.
Dispersion-Managed Breathing-Mode Semiconductor Mode-Locked Ring Laser: Experimental Characterization and Numerical Simulations (2004)

A dispersion-managed breathing-mode mode-locked semiconductor ring laser is studied. The working regime and pulse evolution at the key cavity points are experimentally characterized and numerically simulated. Linearly chirped, asymmetric exponential pulses are generated and externally compressed to 274 fs, which is within 10% of the bandwidth limit. The close agreement between the simulated and the measured results verifies our ability to control the physical mechanisms involved in pulse formation and shaping within the ring cavity.
Performance of CDMA mobile communication systems using antenna arrays (1993)

The use antenna arrays in cellular code division multiple access mobile communications is studied. Techniques to localize each mobile within the cell and to generate tracking adaptive receive (and transmit) beams are addressed. The authors show that such enhancement of the CDMA system results in increased system capacity and improved robustness to power control errors. Preliminary simulation results are presented for capacity and robustness improvements for typical scenarios.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
In vivo effect of granulocyte-macrophage colony-stimulating factor on the kinetics of human acute myeloid leukemia cells. (1991)

Granulocyte-macrophage colony-stimulating factor, (GM-CSF) was given at 8 micrograms/kg daily by continuous i.v. infusion for 72 h to six patients with acute myeloid leukemia (AML) in expansion and one with chronic myeloid leukemia in blastic crisis to determine whether it was possible to augment the proliferative activity of the neoplastic population. The percentage of marrow blasts in S phase (labeling index, LI) was increased in five patients (1.3-, 1.5-, 1.9-, 2.3- and 3.2-fold change). The increase in LI was similar 24 and 48 h after beginning GM-CSF. The RNA Index also increased in patients who showed an increased LI, suggesting that GM-CSF had recruited quiescent neoplastic cells into the cell cycle. Forty eight hours after beginning GM-CSF, chemotherapy was started. The fate of S phase cells, labeled in vivo with bromodeoxyuridine (BrdU) immediately before cytostatic treatment, was monitored. BrdU positive cells were identified by fluorescent antibody for up to 28 days. A preferential killing of BrdU (S phase) cells was observed in 5/7 patients who obtained a complete remission, whereas this was not apparent in the two patients who achieved only a partial remission. Chemotherapy induced a rapid and profound aplasia; its duration, however, was not significantly different from that observed in historical controls. GM-CSF may have a potential role in the treatment of AML, as this study shows that it recruits leukemic cells into the cell cycle without adversely prolonging aplasia after cycle-specific therapy.
Lewis Acid Catalysis of a Diels−Alder Reaction in Water (1996)

Here we report the first detailed study of a Diels−Alder (DA) reaction that is catalyzed by Lewis acids in water. The effect of Co2+, Ni2+, Cu2+ and Zn2+ ions as Lewis acid catalysts on the rate and endo−exo selectivity of the DA reaction between the bidentate dienophiles 3-phenyl-1-(2-pyridyl)-2-propen-1-ones (1a−e) and cyclopentadiene (2) in water has been studied. Relative to the uncatalyzed reaction in acetonitrile, catalysis by 0.010 M Cu(NO3)2 in water accelerates the reaction by a factor of 79 300. The kinetics of the catalyzed reaction were analyzed in terms of equilibrium constants for complexation of the Lewis acid with 1a−e and rate constants for the reaction of the resulting complexes with 2. The rate enhancement imposed upon the uncatalyzed DA reaction of substrates 1 with 2 by water is much more pronounced than that for the catalyzed reaction. The increase of the endo−exo selectivity induced by water in the uncatalyzed process is completely absent for the Lewis acid catalyzed reaction. The modest solvent and substituent effects observed for the catalyzed reaction indicate that the change in charge separation during the activation process is not larger than the corresponding change for the uncatalyzed reaction.
One-Step Conversion of Cellobiose to C<sub>6</sub>-Alcohols Using a Ruthenium Nanocluster Catalyst (2006)

The one-step conversion of cellulose to C6-alcohols via green and energy efficient approaches has, as far as we are aware, not been reported. Such a process presents a considerable challenge, the two key problems being (1) finding a suitable solvent that dissolves the cellulose, and (2) the development of advanced catalytic chemistry for selective cleavage of the C-O-C bonds (glycosidic bonds) connecting glucose residues. The dissolution of cellulose has been recently realized by using ionic liquids as green solvents; there is still no efficient method, such as selective hydrogenation, for the precise C-O-C cleavage under mild conditions, however. Cellobiose is a glucose dimer connected by a glycosidic bond and represents the simplest model molecule for cellulose. We disclose in this communication that the one-step conversion of cellobiose to C6-alcohols can be realized by selectively breaking the C-O-C bonds via selective hydrogenation using a water-soluble ruthenium nanocluster catalyst under 40 bar H2 pressure.
Microphone Array Processing for Distant Speech Recognition: From Close-Talking Microphones to Far-Field Sensors (2012)

Distant speech recognition (DSR) holds the promise of the most natural human computer interface because it enables man-machine interactions through speech, without the necessity of donning intrusive body- or head-mounted microphones. Recognizing distant speech robustly, however, remains a challenge. This contribution provides a tutorial overview of DSR systems based on microphone arrays. In particular, we present recent work on acoustic beam forming for DSR, along with experimental results verifying the effectiveness of the various algorithms described here; beginning from a word error rate (WER) of 14.3% with a single microphone of a linear array, our state-of-the-art DSR system achieved a WER of 5.3%, which was comparable to that of 4.2% obtained with a lapel microphone. Moreover, we present an emerging technology in the area of far-field audio and speech processing based on spherical microphone arrays. Performance comparisons of spherical and linear arrays reveal that a spherical array with a diameter of 8.4 cm can provide recognition accuracy comparable or better than that obtained with a large linear array with an aperture length of 126 cm.
Optical Flow Switched Networks (2010)

Present-day networks are being challenged by dramatic increases in bandwidth demand of emerging applications. We will explore a new network transport, “optical flow switching”, that will enable significant data rate growth, power-efficiency and cost-effective scalability of next-generation networks. Article not available.
Enhancement of the amplitude and lifetime of photoinduced space-charge fields in multidomain ferroelectric crystals (1994)

We demonstrate that the amplitude and lifetime of optically induced space-charge gratings can be dramatically increased in ferroelectric barium titanate by partially depoling the crystal prior to grating recording. By repoling the crystal this space-charge grating produces a refractive index grating capable of diffracting light much more than a grating created in a well-poled, single-domain crystal. This effect is explained in terms of an electric compensation of free charge by the bound charge of the ferroelectric domain walls.
Characterization of Three Abundant mRNAs from Human Ovarian Granulosa Cells (1990)

Three cDNA clones, pHGR122, pHGR11, and pHGR74 containing the coding information for abundant mRNAs were identified from a human ovarian granulosa cell cDNA library. Characterization by nucleotide sequencing revealed that pHGR122 was specific for a collagenase inhibitor and pHGR11 for melanoma-associated antigen ME491. Relative quantification by Northern analysis indicated that collagenase inhibitor mRNA is a major species in granulosa cells. This finding provides evidence for the origin of this protein in follicular fluid as a secretory product of granulosa cells. pHGR11 identified melanoma-associated antigen ME491 as the unexpected product of normal, noncarcinogenic, granulosa cells. pHGR74 has the complete coding information for an unknown protein. Three independent experiments: (i) cell-free translation of pHGR74 RNA; (ii) transcription of suitable restriction fragments followed by cell-free translation; (iii) hydrolysis of the cell-free translation product of pHGR74 RNA by endoproteinase Lys-C, identified one open reading frame coding for an acidic, highly hydrophilic protein of 111 amino acid residues. pHGR74 mRNA is expressed in human testis, prostate, seminal vesicle, and ovarian granulosa cells. A comparative Southern analysis indicates pHGR74 mRNA is species specific and encoded by a single-copy gene.
Intracellular [Na<sup>+</sup>] and Na<sup>+</sup> pump rate in rat and rabbit ventricular myocytes (2002)

Intracellular [Na+] ([Na+]i) is centrally involved in regulation of cardiac Ca2+ and contractility via Na+-Ca2+ exchange (NCX) and Na+-H+ exchange (NHX). Previous work has indicated that [Na+]i is higher in rat than rabbit ventricular myocytes. This has major functional consequences, but the reason for the higher [Na+]i in rat is unknown. Here, resting [Na+]i was measured using the fluorescent indicator SBFI, with both traditional calibration and a novel null-point method (which circumvents many limitations of prior methods). In rabbit, resting [Na+]i was 4.5 +/- 0.4 mM (traditional calibration) and 4.4 mM (null-point). Resting [Na+]i in rat was significantly higher using both the traditional calibration (11.1 +/- 0.7 mM) and the null-point approach (11.2 mM). The rate of Na+ transport by the Na+ pump was measured as a function of [Na+]i in intact cells. Rat cells exhibited a higher V(max) than rabbit (7.7 +/- 1.1 vs. 4.0 +/- 0.5 mM x min(-1)) and a higher K(m) (10.2 +/- 1.2 vs. 7.5 +/- 1.1 mM). This results in little difference in pump activity for a given [Na+]i below 10 mM, but at measured resting [Na+]i levels the pump-mediated Na+ efflux is much higher in rat. Thus, Na+ pump rate cannot explain the higher [Na+]i in rat. Resting Na+ influx rate was two to four times higher in rat, and this accounts for the higher resting [Na+]i. Using tetrodotoxin, HOE-642 and Ni2+ to block Na+ channels, NHX and NCX, respectively, we found that all three pathways may contribute to the higher resting Na+ influx in rat (albeit differentially). We conclude that resting [Na+]i is higher in rat than in rabbit, that this is caused by higher resting Na+ influx in rat and that a higher Na+,K+-ATPase pumping rate in rat is a consequence of the higher [Na+]i.
Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: A comparison with topical menthol (2014)

Menthol has historically been used topically to alleviate various pain conditions. At low concentrations, this non-selective TRPM8 agonist elicits a cooling sensation, however higher concentrations result in cold hyperalgesia in normal subjects and paradoxically analgesia in neuropathic patients. Through behavioural and electrophysiological means, we examined whether this back-translated into a pre-clinical rodent model. Menthol was applied topically to the hind paws of naive and spinal nerve-ligated (SNL) rats. In behavioural assays, menthol did not affect withdrawal thresholds to mechanical stimulation and 10% and 40% menthol rarely sensitised withdrawals to innocuous cooling in naïve rats. However, in SNL rats, 10% and 40% menthol alleviated cold hypersensitivity. This was partly corroborated by in vivo electrophysiological recordings of dorsal horn lamina V/VI neurones. As several studies have implicated TRPM8 in analgesia, we examined whether a novel systemically available TRPM8 agonist, M8-Ag, had more potent anti-hyperalgesic effects than menthol in neuropathic rats. In vitro, M8-Ag activates TRPM8, expressed in HEK293 cells, with an EC50 of 44.97 nM. In vivo, M8-Ag inhibited neuronal responses to innocuous and noxious cooling in SNL rats with no effect in sham-operated rats. This effect was modality selective; M8-Ag did not alter neuronal responses to mechanical, heat or brush stimulation. In addition, M8-Ag attenuated behavioural hypersensitivity to innocuous cooling but not mechanical stimulation. These data suggest that menthol induced hyperalgesia is not consistently replicable in the rat and that the analgesic properties are revealed by injury. Systemic TRPM8 agonists might be beneficial in neuropathy without affecting normal cold sensitivity.
Treatment of Adenovirus Infections in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation (2001)

Retrospective analysis of 303 patients who underwent allogeneic hematopoietic stem cell transplantation identified 35 (11.5%) with adenovirus infection. Among them, 22 received specific therapy. As first-line therapy, 18 were treated with intravenous ribavirin, 3 with cidofovir, and 1 with vidarabine. Moreover, 2 received donor leukocyte infusion in combination with ribavirin, and 1 received it after failing to respond to other therapies. Seven survived (31.8%; 3 of 13 who received ribavirin alone and 2 of 3 who received cidofovir). Among the 5 patients treated with combined strategies, 2 who received donor leukocyte infusions showed clearance of all symptoms. Acute graft-versus-host disease grade > or = 3 (P = .01) and a long delay between infection and treatment (P = .05) correlated with a greater risk of treatment failure. In conclusion, ribavirin and vidarabine are ineffective options, particularly for patients at who are high risk of acquiring disseminated adenovirus disease. Conversely, cidofovir or donor leukocyte infusions seem to be encouraging approaches if initiated early.
Ultralinear bistable electro-optic polarization modulator (1978)

An optical device utilizing optical feedback has been constructed with a Pockels cell and polarizing components. Two modes of operation of the device are demonstrated. Both modes exhibit optical bistability. It is demonstrated that in one mode of operation the nonlinear dependence of the output intensity as a function of an input optical or electrical signal can be made arbitrarily small compared to the linear dependence.
Validation of overnight oximetry to diagnose patients with moderate to severe obstructive sleep apnea (2015)

Overnight pulse oximetry provides satisfactory diagnostic performance in detecting severe OSA patients. Home-styled oximetry may be a tool for severe OSA diagnosis.
Distribution of covalently bound and non-covalently bound secretory component on sbuclasses of rabbit secretory IgA. (1975)

The distribution of non-covalently bound secretory component (SC) on the two subclasses, IgA-f and IgA-g of rabbit secretory IgA (sIgA) was determined; the two subclasses were separated from each other by the use of antibody-immunosorbent columns and were subjected to SDS polyacrylamide gel electrophoresis. No SC appeared to be dissociated from the IgA-f molecules from each of 11 different rabbits; the IgA-g molecules, however, did have SC which was dissociated by SDS. Thus, all of the noncovalently bound SC on rabbit sIgA resides on the IgA-g subclass molecules.
Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb. (1996)

Alterations in expression of or responsiveness to transforming growth factor beta (TGF-beta) are frequently found in human and animal epithelial cancers and are though to be important for loss of growth control in the neoplastic cell. We show here that keratinocyte cell lines from mice with a targeted deletion of the TGF-beta 1 gene have significantly increased frequencies of gene amplification in response to the drug N-phosphonoacetyl-L-aspartate (PALA) compared to TGF-beta 1-expressing control keratinocyte cell lines. In contrast to the control lines, the PALA-mediated G1 arrest did not occur in the TGF-beta 1 null keratinocytes despite the presence of wild-type p53 in both genotypes. Exogenous TGF-beta 1 suppresses gene amplification in the null keratinocytes at concentrations that do not cause a G1 growth arrest and in human tumor cell lines that are insensitive to TGF-beta 1-mediated growth inhibition. The pathway of TGF-beta 1 suppression is independent of the p53 and Rb genes, but requires an intact TGF-beta type II receptor. These studies reveal a novel TGF-beta-mediated pathway regulating genomic stability and suggest that defects in TGF-beta signaling may have profound effects on tumor progression independent of cell proliferation.
Fine-grained dynamic voltage scaling on OLED display (2012)

Organic Light Emitting Diode (OLED) has emerged as the new generation display technique for mobile multimedia devices. Compared to existing technologies OLEDs are thinner, brighter, lighter, and cheaper. However, OLED panels are still the biggest contributor to the total power consumption of mobile devices. In this work, we proposed a fine-grained dynamic voltage scaling (FDVS) technique to reduce the OLED power. An OLED panel is partitioned into multiple display areas of which the supply voltage is adaptively adjusted based on the displayed content. A DVS-friendly OLED driver design is also proposed to enhance the color accuracy of the OLED pixels at the scaled supply voltage. Our experimental results show that compared to the existing global DVS technique, FDVS technique can achieve 25.9%∼43.1% more OLED power saving while maintaining a high image quality measured by Structural Similarity Index (SSIM=0.98). The further analysis shows shat FDVS technology can also effectively reduce the color remapping cost when color compensation is required to improve the image quality of an OLED panel working at a scaled voltage.
Measurement of the state of battery charge using an improved loaded voltmeter test method (1982)

An improved loaded voltmeter test (ILVT) was developed based on the preparation of a table of voltage measurements of the tested battery with a constant resistor load as a function of the state of charge. The function is stored in the memory of the microcomputer; when a certain value of the charge is then needed, it can be found using the ILVT and the stored function. The action of the power system is not disturbed. A circuit based on this method was built and tested at Tel Aviv University, Israel. Half as many errors occurred when the ILVT was used as when the conventional loaded voltmeter test was used. Although the system consists of only lead-acid batteries, the ILVT is also suitable for testing other types of batteries.
Production of<i>N</i>-Acetylglucosamine Deacetylase by<i>Vibrio cholerae</i>Non-O1 (1994)

Vibrio cholerae non-O1 (1148 A) produced β-N-acetylglucosamini-dase and N-acetylglucosamine (GlcNAc) deacetylase intracellularly when grown in chitin or GlcNAc containing medium. It also secreted chitinase only in the chitin-containing medium. The partially purified GlcNAc deacetylase deacetylated GlcNAc but not chitin oligosaccharides, the dimer to hexamer of GlcNAc. We also detected the reaction product by capillary electrophoresis.
Effect of Screw Torque Level on Cortical Bone Pullout Strength (2007)

Within the limitations of our study involving the testing of 1 type of screw purchase in ovine tibiae, results demonstrate that clinical levels of lag screw tightening (86% Tmax) are past the yield point of bone. Tightening to these high torque levels can cause damage leading to compromised holding strength. Further research is still required to establish the appropriate level of torque required for achieving optimal fracture fixation and healing.
Complexity of vaginal microflora as analyzed by PCR denaturing gradient gel electrophoresis in a patient with recurrent bacterial vaginosis. (2005)

BV is not well understood in terms of its causative organisms, and further studies appear warranted using non-culture, molecular methods. Only when the identities of infecting organisms are confirmed can effective therapy be devized. Such therapy may include the use of probiotic lactobacilli, but only using strains which confer a benefit on the vagina of pre- and postmenopausal women.