gebhart/patrepeval huggingface dataset:
801. Reactions of methazonic acid. Part IV. Further experiments with 3-amino-4-arylquinolines (1953)

D. W. Ockenden and K. Schofield, J. Chem. Soc., 1953, 3914 DOI: 10.1039/JR9530003914
Utility of a novel inflammatory marker, GlycA, for assessment of rheumatoid arthritis disease activity and coronary atherosclerosis (2015)

GlycA is a novel inflammatory marker that may be useful for assessment of disease activity and is associated with coronary artery atherosclerosis in patients with RA.
High-performance planar heterojunction perovskite solar cells: Preserving long charge carrier diffusion lengths and interfacial engineering (2014)

We demonstrate that charge carrier diffusion lengths of two classes of perovskites, CH3NH3PbI3−x Cl x and CH3NH3PbI3, are both highly sensitive to film processing conditions and optimal processing procedures are critical to preserving the long carrier diffusion lengths of the perovskite films. This understanding, together with the improved cathode interface using bilayer-structured electron transporting interlayers of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM)/ZnO, leads to the successful fabrication of highly efficient, stable and reproducible planar heterojunction CH3NH3PbI3−x Cl x solar cells with impressive power-conversion efficiencies (PCEs) up to 15.9%. A 1-square-centimeter device yielding a PCE of 12.3% has been realized, demonstrating that this simple planar structure is promising for large-area devices.
Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis (2015)

As an attractive strategy developed rapidly in recent years, nanocrystals are used to deliver insoluble drugs. PEGylation may further prolong the circulation time of nanoparticles and improve the therapeutic outcome of drugs. In this study, paclitaxel (PTX) nanocrystals (PTX-NCs) and PEGylated PTX nanocrystals (PEG-PTX-NCs) were prepared using antisolvent precipitation augmented by probe sonication. The characteristics and antitumor efficacy of nanocrystals were investigated. The results indicated that the nanocrystals showed rod-like morphology, and the average particle size was 240 nm and 330 nm for PTX-NCs and PEG-PTX-NCs, respectively. The PEG molecules covered the surface of nanocrystals with an 11.54 nm fixed aqueous layer thickness (FALT), much higher than that of PTX-NCs (0.2 nm). PEG-PTX-NCs showed higher stability than PTX-NCs under both storage and physiological conditions. In breast cancer xenografted mice, PEG-PTX-NCs showed significantly better tumor inhibition compared to saline (p < 0.001) and PTX-NC groups (p < 0.05) after intravenous administration. In a model of lung tumor metastasis quantified by the luciferase activity, the PEG-PTX-NCs group showed higher anticancer efficacy not only than saline and PTX-NCs groups, but also than Taxol®, achieving an 82% reduction at the end of the experiment. These studies suggested the potential advantages of PEGylated PTX nanocrystals as alternative drug delivery systems for anticancer therapy.
Polyphenon E<sup>®</sup>: a new treatment for external anogenital warts (2009)

Background External genital warts (EGWs, condylomata acuminata) are a common, highly contagious disease caused by human papillomavirus (HPV), predominantly HPV 6 and HPV 11. Green tea catechins have been identified for their immunostimulatory, antiproliferative and antitumour properties. Two phase III trials evaluated treatment of EGWs with ointment containing a mixture of green tea catechins (Polyphenon E), U.S. adopted name: sinecatechins). Objectives To obtain additional data on the efficacy and safety of Polyphenon E ointment in the treatment of EGWs from two randomized, double-blind, vehicle-controlled trials. Methods Men and women aged > or = 18 years (n = 1005), with two to 30 EGWs (12-600 mm(2) total area) applied vehicle (G(Veh); n = 207), Polyphenon E ointment 10% (G(10%); n = 401) or Polyphenon E ointment 15% (G(15%); n = 397) three times daily until complete clearance of all EGWs (baseline + new EGWs) or for a maximum of 16 weeks. Results A total of 1004 patients were evaluable for safety and 986 for efficacy; 838 completed treatment after 16 weeks. Complete clearance of all EGWs was obtained in 53.6% (G(10%)) and 54.9% (G(15%)) of patients with Polyphenon E vs. vehicle (35.4%) (P < 0.001). Statistically significant differences in clearance rates appeared after 6 weeks of active treatment. Odds ratios vs. G(Veh) for G(10%) [2.10; 95% confidence interval (CI) 1.49-2.98] and G(15%) (2.22; 95% CI 1.57-3.14) indicated about a twofold higher chance of complete clearance under active treatment. Time to complete clearance was shorter with active treatment (hazard ratios 1.57 and 1.87, respectively, for G(10%) and G(15%) vs. G(Veh) groups; P < 0.001). Recurrence rates during follow-up were low and similar across groups: 5.8%, 6.8% and 6.5% (G(Veh), G(10%) and G(15%) groups, respectively). Adverse events were evenly distributed across groups ( approximately 30% of patients). Severe local signs were more frequent but moderate in the active treatment groups (1.5%, 9.2% and 13.5% for G(Veh), G(10%) and G(15%) groups, respectively). Conclusions Polyphenon E ointment is effective and well tolerated in the treatment of EGWs.
Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection (2017)

Adoptive transfer of T cells engineered to express a hepatitis B virus-specific (HBV-specific) T cell receptor (TCR) may supplement HBV-specific immune responses in chronic HBV patients and facilitate HBV control. However, the risk of triggering unrestrained proliferation of permanently engineered T cells raises safety concerns that have hampered testing of this approach in patients. The aim of the present study was to generate T cells that transiently express HBV-specific TCRs using mRNA electroporation and to assess their antiviral and pathogenetic activity in vitro and in HBV-infected human liver chimeric mice. We assessed virological and gene-expression changes using quantitative reverse-transcriptase PCR (qRT-PCR), immunofluorescence, and Luminex technology. HBV-specific T cells lysed HBV-producing hepatoma cells in vitro. In vivo, 3 injections of HBV-specific T cells caused progressive viremia reduction within 12 days of treatment in animals reconstituted with haplotype-matched hepatocytes, whereas viremia remained stable in mice receiving irrelevant T cells redirected toward hepatitis C virus-specific TCRs. Notably, increases in alanine aminotransferase levels, apoptotic markers, and human inflammatory cytokines returned to pretreatment levels within 9 days after the last injection. T cell transfer did not trigger inflammation in uninfected mice. These data support the feasibility of using mRNA electroporation to engineer HBV TCR-redirected T cells in patients with chronic HBV infection.
Image Super-Resolution Using Dense Skip Connections (2017)

Recent studies have shown that the performance of single-image super-resolution methods can be significantly boosted by using deep convolutional neural networks. In this study, we present a novel single-image super-resolution method by introducing dense skip connections in a very deep network. In the proposed network, the feature maps of each layer are propagated into all subsequent layers, providing an effective way to combine the low-level features and high-level features to boost the reconstruction performance. In addition, the dense skip connections in the network enable short paths to be built directly from the output to each layer, alleviating the vanishing-gradient problem of very deep networks. Moreover, deconvolution layers are integrated into the network to learn the upsampling filters and to speedup the reconstruction process. Further, the proposed method substantially reduces the number of parameters, enhancing the computational efficiency. We evaluate the proposed method using images from four benchmark datasets and set a new state of the art.
[MR imaging of the femoral marrow in adult acute leukemia: correlation of MRI patterns with FAB subtype and prognosis]. (1996)

MR imaging of the femoral marrow was performed in 36 patients with untreated acute myeloid leukemia (AML) and 7 patients with acute lymphocytic leukemia (ALL). The MRI appearance was classified into five patterns: 1) fatty marrow; 2) faint signal; 3) nodular pattern; 4) heterogeneous infiltration; and 5) diffuse infiltration. The MRI patterns of the femoral marrow were compared among the FAB subtypes of acute leukemia, and the MRI patterns were correlated with prognosis. All five MRI patterns were observed in the femoral marrow in adult acute leukemia, and diffuse infiltration was most commonly seen (41.9%). A completely fatty marrow was also depicted in two cases (4.7%) and faint signal in four cases (9.3%) in spite of untreated acute leukemia. The M2 subtype of AML tended to be demonstrated as a minimally abnormal MRI finding, which was significantly different from the other types of AML. The patients who showed fatty marrow or faint signal were thought to have a good prognosis, while diffuse or heterogeneous infiltration was regarded as a poor prognostic sign. However, there were some exceptions to these rules, and no significant differences were revealed in prognosis between minimally abnormal and advanced MRI patterns. We concluded that MRI of the femoral marrow could be useful in the assessment of tumor volume of adult acute leukemia, and that there were limitations to predicting prognosis on the basis of the MRI manifestations.
Functional expression of the rat brown adipose tissue uncoupling protein in <i>Saccharomyces cerevisiae</i> (1992)

The uncoupling protein (UCP) from mammalian brown adipose tissue is an integral component of the mitochondrial inner membrane where it dissipates the proton electrochemical gradient. UCP is transported into mitochondria from the cytosol but lacks a cleavable targeting peptide. We have expressed the rat UCP in Saccharomyces cerevisiae and shown that this protein, which is not normally found in yeast, is targeted to the mitochondria where it disrupts mitochondrial function, probably by uncoupling oxidative phosphorylation. The observed growth defect is dependent upon the level of expression of UCP. When the unmodified UCP cDNA is expressed in yeast under the control of the GAL10 promoter no defect in growth is observed. We have inserted the UCP coding sequence behind the strong phosphoglycerate kinase promoter under the control of the GAL1-10 upstream activation site and introduced a yeast consensus sequence (ATAATG) at the translation start site. We have found that UCP expressed in S. cerevisiae is targeted to mitochondria and that its expression induces a marked growth defect on non-fermentable carbon sources in a manner dependent on induction with galactose.
Emergent Properties of Microbial Activity in Heterogeneous Soil Microenvironments: Different Research Approaches Are Slowly Converging, Yet Major Challenges Remain (2018)

Over the last 60 years, soil microbiologists have accumulated a wealth of experimental data showing that the bulk, macroscopic parameters (e.g., granulometry, pH, soil organic matter, and biomass contents) commonly used to characterize soils provide insufficient information to describe quantitatively the activity of soil microorganisms and some of its outcomes, like the emission of greenhouse gasses. Clearly, new, more appropriate macroscopic parameters are needed, which reflect better the spatial heterogeneity of soils at the microscale (i.e., the pore scale) that is commensurate with the habitat of many microorganisms. For a long time, spectroscopic and microscopic tools were lacking to quantify processes at that scale, but major technological advances over the last 15 years have made suitable equipment available to researchers. In this context, the objective of the present article is to review progress achieved to date in the significant research program that has ensued. This program can be rationalized as a sequence of steps, namely the quantification and modeling of the physical-, (bio)chemical-, and microbiological properties of soils, the integration of these different perspectives into a unified theory, its upscaling to the macroscopic scale, and, eventually, the development of new approaches to measure macroscopic soil characteristics. At this stage, significant progress has been achieved on the physical front, and to a lesser extent on the (bio)chemical one as well, both in terms of experiments and modeling. With regard to the microbial aspects, although a lot of work has been devoted to the modeling of bacterial and fungal activity in soils at the pore scale, the appropriateness of model assumptions cannot be readily assessed because of the scarcity of relevant experimental data. For significant progress to be made, it is crucial to make sure that research on the microbial components of soil systems does not keep lagging behind the work on the physical and (bio)chemical characteristics. Concerning the subsequent steps in the program, very little integration of the various disciplinary perspectives has occurred so far, and, as a result, researchers have not yet been able to tackle the scaling up to the macroscopic level. Many challenges, some of them daunting, remain on the path ahead. Fortunately, a number of these challenges may be resolved by brand new measuring equipment that will become commercially available in the very near future.
An Algorithmic Definition of the Axial Map (2005)

The fewest-line axial map, often simply referred to as the ‘axial map’, is one of the primary tools of space syntax. Its natural language definition has allowed researchers to draw consistent maps that present a concise description of architectural space; it has been established that graph measures obtained from the map are useful for the analysis of pedestrian movement patterns and activities related to such movement: for example, the location of services or of crime. However, the definition has proved difficult to translate into formal language by mathematicians and algorithmic implementers alike. This has meant that space syntax has been criticised for a lack of rigour in the definition of one of its fundamental representations. Here we clarify the original definition of the fewest-line axial map and show that it can be implemented algorithmically. We show that the original definition leads to maps similar to those currently drawn by hand, and we demonstrate that the differences between the two may be accounted for in terms of the detail of the algorithm used. We propose that the analytical power of the axial map in empirical studies derives from the efficient representation of key properties of the spatial configuration that it captures.
Effect of Seed Maturation and Genotype on Seed Vigor in Maize (1995)

High quality seed is the goal of all corn ( Zea mays L.) seed producers. The objective of this investigation was to relate several indicators of seed maturity [black layer (BL), milk line (ML)], to seed vigor (cold test and conductivity) over a wide range of dent corn genotypes and environments. Two inbreds (B73, Mo17), four single and modified single cross hybrids, and seven open pollinated, double and three way cross hybrids were produced at two locations (Lexington and Danville, KY) from 1985 to 1989. In 1986 and 1987, a complete plant defoliation treatment was also imposed on inbred, single and double cross hybrids. Seed harvests were started at approximately 30 d after pollination and continued at short intervals (≈4 d). Seed vigor reached maximum levels at physiological maturity (PM) which occurred at black layer Stage 4 for single and double cross progeny. Maximum seed vigor occurred slightly later for inbreds between black layer Stages 4 and 5. There was a significant quadratic relationship between seed vigor (cold test and conductivity) and black layer maturity across all years in each genotype grouping including stay‐green hybrids. When plants were stressed by defoliation or high temperatures during seed development, the seed weight was reduced, seed maturation was accelerated, but maximum seed vigor occurred at the same stage (BL4) as for nonstressed plants. Maximum seed vigor levels consistently occurred at physiological maturity as determined by black layer (or milk line), which can be used by seed producers to estimate the date of harvest.
IP MULTIMEDIA SUBSYSTEMS - Mobility Testbed for 3GPP2-Based Multimedia Domain Networks (2007)

Wireless service providers strive to preserve the quality of service and user experience for mobile users. Several standards bodies are defining architectures that can be used as a platform to provide secure and seamless services to these mobile users. These architectures aim to provide several required functions such as signaling, configuration, security association, encryption, and billing. However, the placement of several functional components and their interaction at several layers contributes to the operational complexity and thus affects the optimal results. Testbed realization of any standardized architecture can help investigate the underlying networking issues. In this article, we describe a mobility test bed implementation based on one of the architecture alternatives of 3GPP2, where the outbound signaling servers are distributed around the edges of the network. We experiment with three different hand-off techniques and analyze the associated experimental results. Analysis of these experimental results and experiences obtained from the testbed implementation can be helpful to any service provider that plans to deploy a version of the MMD (multimedia domain) architecture with distributed signaling servers.
Current prognostic factors for prostate carcinoma (1996)

Current prognostic factors for prostate carcinoma provide important information for patient care and research. However, new methods to define pretreatment prognosis and needed to assist clinicians and patients in making therapeutic choices for prostate carcinoma. The ideal method with which to incorporate the information attained from anatomic stage, histologic grade, PSA level, age, and comorbidity into a manageable prognostic score is uncertain and studies on this topic should be a high priority research objective.
Efficient Detection of Complex Event Patterns Using Lazy Chain Automata (2016)

Complex Event Processing (CEP) is an emerging field with important applications in many areas. CEP systems collect events arriving from input data streams and use them to infer more complex events according to predefined patterns. The Non-deterministic Finite Automaton (NFA) is one of the most popular mechanisms on which such systems are based. During the event detection process, NFAs incrementally extend previously observed partial matches until a full match for the query is found. As a result, each arriving event needs to be processed to determine whether a new partial match is to be initiated or an existing one extended. This method may be highly inefficient when many of the events do not result in output matches. We present a lazy evaluation mechanism that defers processing of frequent event types and stores them internally upon arrival. Events are then matched in ascending order of frequency, thus minimizing potentially redundant computations. We introduce a Lazy Chain NFA, which utilizes the above principle, and does not depend on the underlying pattern structure. An algorithm for constructing a Lazy Chain NFA for common pattern types is presented, including conjunction, negation and iteration. Finally, we experimentally evaluate our mechanism on real-world stock trading data. The results demonstrate a performance gain of two orders of magnitude over traditional NFA-based approaches, with significantly reduced memory resource requirements.
Biotin and Other Water-Soluble Vitamins Are Key Growth Factors for Alfalfa Root Colonization by<i>Rhizobium meliioti</i>1021 (1996)

Rhizosphere growth limitations imposed on Rhizobium meliloti by availability of biotin, thiamine, and riboflavin were overcome by adding nanomolar amounts of these vitamins. Studies done with R. meliloti 1021 showed that both synthesis and uptake of biotin promote colonization of alfalfa roots. Two lines of evidence indicated that plant-derived biotin normally promotes root colonization: (i) adding avidin significantly (P < or = 0.01) reduced rhizosphere growth of R meliloti 1021, and (ii) growth of Tn5-induced biotin auxotrophs still increased 10-fold in the rhizosphere. Synthesis, however, is the more important source of biotin for R. meliloti 1021 because in root colonization tests biotin auxotrophs competed very poorly with the parent strain. Mutations conferring biotin auxotrophy were closely linked on a single restriction fragment, and one was complemented with the Escherichia coli bio operon. Initial nucleotide sequencing and DNA-DNA hybridization tests showed the biotin synthesis genes in R. meliloti are quite different from those in E. coli.
Genomic Sequence of C <sub>1</sub> , the First Streptococcal Phage (2003)

C(1), a lytic bacteriophage infecting group C streptococci, is one of the earliest-isolated phages, and the method of bacterial classification known as phage typing was defined by using this bacteriophage. We present for the first time a detailed analysis of this phage by use of electron microscopy, protein profiling, and complete nucleotide sequencing. This virus belongs to the Podoviridae family of phages, all of which are characterized by short, noncontractile tails. The C(1) genome consists of a linear double-stranded DNA molecule of 16,687 nucleotides with 143-bp inverted terminal repeats. We have assigned functions to 9 of 20 putative open reading frames based on experimental substantiation or bioinformatic analysis. Their products include DNA polymerase, holin, lysin, major capsid, head-tail connector, neck appendage, and major tail proteins. Additionally, we found one intron belonging to the HNH endonuclease family interrupting the apparent lysin gene, suggesting a potential splicing event yielding a functional lytic enzyme. Examination of the C(1) DNA polymerase suggests that this phage utilizes a protein-primed mechanism of replication, which is prominent in the phi29-like members of Podoviridae. Consistent with this evidence, we experimentally determined that terminal proteins are covalently attached to both 5' termini, despite the fact that no homology to known terminal proteins could be elucidated in any of our open reading frames. Likewise, comparative genomics revealed no close evolutionary matches, suggesting that the C(1) bacteriophage is a unique member of the Podoviridae.