gebhart/patrepeval huggingface dataset:
Citrullination in extra-articular manifestations of rheumatoid arthritis (2006)

Citrullination is present in extra-articular manifestations of RA such as IP and nodules. In contrast to the high specificity of anti-citrulline antibodies in RA, citrullination is not only restricted to RA but can also be observed in idiopathic IP. Whether citrullination significantly contributes to the initiation or perpetuation of autoimmunity or merely reflects ongoing inflammation remains to be clarified.
Brillouin Scattering in Polymer Optical Fibers: Fundamental Properties and Potential Use in Sensors (2011)

We review the fundamental properties of Brillouin scattering in a perfluorinated graded-index polymer optical fiber (PFGI-POF) with 120 μm core diameter. The experiments were performed at 1.55 μm telecommunication wavelength. The Brillouin frequency shift (BFS) and the Brillouin bandwidth were 2.83 GHz and 105 MHz, respectively. The Brillouin gain coefficient was calculated to be 3.09 × 10−11 m/W, which was comparable to that of fused silica fibers. The Brillouin threshold power of the 100 m POF was estimated to be as high as 24 W, which can be, for practical applications, reduced by using POFs with smaller cores. These properties were compared with those of silica-based graded-index multi-mode fibers. We also investigated the BFS dependences on strain and temperature. They showed negative dependences with coefficients of −121.8 MHz/% and −4.09 MHz/K, respectively, which are −0.2 and −3.5 times as large as those in silica fibers. These BFS dependences indicate that the Brillouin scattering in PFGI-POFs can be potentially applied to high-accuracy temperature sensing with reduced strain sensitivity.
Priority inheritance and ceilings for distributed mutual exclusion (2003)

The contributions of this paper are threefold. First, a solution to the problem of prioritized mutual exclusion in a distributed system is proved correct. This protocol is based on fewer requirements than prioritized extensions of other protocols and outperforms other protocols with an average complexity of /spl theta/(log n) and a worst-case complexity of O(n) messages for n nodes. Second, the concept of relative fairness is introduced which quantifies the relation between parallel events in terms of their ordering in the absence of synchronized clocks. This concept is applied to the protocol in order to determine a requirement to guarantee a certain order between events when message delays are bounded. Third, the protocol is extended to prevent priority inversion by incorporating the priority inheritance and the priority ceiling protocols. The extensions are shown to integrate well with the original protocol. They impose the same message overhead as mentioned before for each dynamically raised priority due to resource contention while early priority boosting, such as for the priority ceiling emulation protocol, requires no additional overhead at all.
Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension (2008)

Idiopathic pulmonary arterial hypertension (IPAH) is a fatal disease characterised by elevated blood pressure in the pulmonary circulation. Initial vasoconstriction, proliferation of pulmonary arterial smooth muscle cells (PASMC) and increased deposition of extracellular matrix (ECM) contribute to pathological remodelling of pulmonary arterioles in IPAH. Glycosaminoglycans (GAGs), components of the ECM, control cellular proliferation and differentiation, but their expression in IPAH remains elusive. In the present study, GAG expression was investigated in the lungs of patients with IPAH or control transplant donors, and expression and localisation of GAG-metabolising enzymes were analysed in vivo and in vitro. A significant increase in the expression of hyaluronic acid (HA) was detected in IPAH lungs, associated with increased hyaluronan synthase (Has)1 and decreased hyaluronoglucosaminidase 1 gene expression, as assessed by quantitative RT-PCR and Western blotting. HAS1 protein localised to PASMC in vivo and increased HA deposition was observed in remodelled pulmonary arteries in IPAH. Transforming growth factor-beta1, a profibrotic growth factor, led to increased HA secretion and HAS1 expression in primary PASMC. The results demonstrate an increased hyaluronic acid content in idiopathic pulmonary arterial hypertension lungs, associated with increased hyaluronan synthase 1 and decreased hyaluronoglucosaminidase 1 gene expression. Synergistic regulation of glycosaminoglycan-metabolising enzymes in favour of accumulation may, thus, regulate pathological vascular remodelling in idiopathic pulmonary arterial hypertension lungs.
A novel automatic seed point selection algorithm for breast ultrasound images (2008)

Region growing is a frequently used segmentation method for medical ultrasound images processing. The first step of region growing is selecting the seed point which is inside the breast lesion. Most of the region growing methods require manually selecting the seed point which needs human interaction. To make the segmentation completely automatic, we propose a new automatic seed point selecting method for region growing algorithm. The method is validated on our database with 105 ultrasound images with breast masses and it is compared with other automatic seed point selecting method on the same database. Quantitative experiment results show that our proposed method can successfully find the proper seed points for 95.2% of the US images in the database which is much more robust than other automatic seed point selection methods.
Pharmacokinetics of the Cardioprotector ADR-529 (ICRF-187) in Escalating Doses Combined With Fixed-Dose Doxorubicin (1992)

We recommend that an ADR-529 dose of 600 mg/m2 be given with single-agent doxorubicin at a dose of 60 mg/m2 in future studies.
Gynecological laparoscopy 1973: the state of the art. (1974)

A survey was taken of American Association of Gynecological Laparoscopist (AAGL) members in order to gain knowledge of their operative techniques and insight into the complications they had encountered. At the time of the survey 47% of the respondents had personally performed less than 100 laparoscopies and 52% had performed upwards of 100 procedures (total respondents 496). A combination of self-teaching participation in formal courses and preceptorships was the means by which the preponderance (33%) of respondents gained their proficiency. Intubated general anesthesia had been used by 93% of the respondents but was preferred by only 82%. Mask general was used by 39% and preferred by only 12%. Local anesthetics were accorded in 18% previous use rate but only a 1% preference rate. Carbon dioxide was the gas of choice for 91% of the respondents during insufflation of the peritoneal cavity. The majority of laparoscopists (61%) required between 16 and 30 minutes to complete the operative procedure. The 2-puncture technique was most often used by 68% of the physicians. 15% used 1-puncture technique and 7% used both. The most common patient complication was subcutaneous emphysema. The most frequent complication of anesthesia during laparoscopy was cardiac arrhythmias reported by 25% of the respondents. 70% of physicians experiencing complications with anesthesia felt they were not related to the choice of gas for insufflation.
Wide-Band Coaxial-to-Coplanar Transition (2007)

Targeting the transition from a coaxial wave guide to a coplanar wave guide (CPW), a microwave and millimeter-wave wide-band coaxial-to-coplanar transition is proposed. This design connects the coaxial inner conductor to the CPW center conductor in a perpendicular manner to directly couple, on the same plane, the radial high-frequency electric field in the coax to the gap between the CPW's center conductor and ground plane. The performance of the proposed transition was compared with those of the conventional transition by experiments and electromagnetic field simulations, and it was found that the proposed method is independent of CPW shape and that it exhibits good matching performance in comparison to the conventional method especially in high-frequency bands above 15 GHz.
Peat (1899)

Peat Get access J. L. Anderson J. L. Anderson 1Edinburgh Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s9-IV, Issue 82, 22 July 1899, Pages 75–76, https://doi.org/10.1093/nq/s9-IV.82.75h Published: 22 July 1899
Development and validation of a novel protein extraction methodology for quantitation of protein expression in formalin‐fixed paraffin‐embedded tissues using western blotting (2009)

The development of efficient formaldehyde cross-link reversal strategies will make the vast diagnostic tissue archives of pathology departments amenable to prospective and retrospective translational research, particularly in biomarker-driven proteomic investigations. Heat-induced antigen retrieval strategies (HIARs) have achieved varying degrees of cross-link reversal, potentially enabling archival tissue usage for proteomic applications outside its current remit of immunohistochemistry (IHC). While most successes achieved so far have been based on retrieving tryptic peptide fragments using shot-gun proteomic approaches, attempts at extracting full-length, non-degraded, immunoreactive proteins from archival tissue have proved challenging. We have developed a novel heat-induced antigen retrieval strategy using SDS-containing Laemmli buffer for efficient intact protein recovery from formalin-fixed tissues for subsequent analysis by western blotting. Protocol optimization and comparison of extraction efficacies with frozen tissues and current leader methodology is presented. Quantitative validation of methodology was carried out in a cohort of matched tumour/normal, frozen/FFPE renal tissue samples from 10 patients, probed by western blotting for a selected panel of seven proteins known to be differentially expressed in renal cancer. Our data show that the protocol enables efficient extraction of non-degraded, full-length, immunoreactive protein, with tumour versus normal differential expression profiles for a majority of the panel of proteins tested being comparable to matched frozen tissue controls (rank correlation, r = 0.7292, p < 1.825e-09). However, the variability observed in extraction efficacies for some membrane proteins emphasizes the need for cautious interpretation of quantitative data from this subset of proteins. The method provides a viable, cost-effective quantitative option for the validation of potential biomarker panels through a range of clinical samples from existing diagnostic archives, provided that validation of the method is first carried out for the specific proteins under study.
Interrater Reliability of a Modified Ashworth Scale of Muscle Spasticity (1987)

We undertook this investigation to determine the interrater reliability of manual tests of elbow flexor muscle spasticity graded on a modified Ashworth scale. We each independently graded the elbow flexor muscle spasticity of 30 patients with intracranial lesions. We agreed on 86.7% of our ratings. The Kendall's tau correlation between our grades was .847 (p less than .001). Thus, the relationship between the raters' judgments was significant and the reliability was good. Although the results were limited to the elbow flexor muscle group, we believe them to be positive enough to encourage further trials of the modified Ashworth scale for grading spasticity.
Towards a Teaching Model for the Classroom of the Twenty-First Century (1993)

No abstract available for this article.
Single beam synthesis from thinned arrays (1984)

A readily steerable, ambiguity-free beam is formed in real time from a receive aperture containing a sparsely populated array of transducer elements with selected spacings. The system approach utilizes multiple phase-matched local oscillators in the process of producing at an IF a full set of synthetic spatial frequencies which are similar to the actual spatial frequencies associated with all conventional apertures. A summation of these synthetic spatial frequencies produces the scannable beam with at least as much resolution and freedom from interference as that obtainable from the same size aperture fully filled with closely spaced elements. Beam formation is accomplished either within the system by using a beam forming network or externally by applying the synthesized spatial frequencies to a fully filled transmit array of elements (an autonomous retrodirective system). Experimental measurements at a rf demonstrate that the principles are valid. Superdirectivity, circular arrays (for cylindrical coverage), self-steering arrays, real-time holography, passive distance measurement, and frequency/phase modulation recovery from incident carriers are possible extensions of the system approach.
Multiplexing siRNAs to compress RNAi-based screen size in human cells (2007)

Here we describe a novel strategy using multiplexes of synthetic small interfering RNAs (siRNAs) corresponding to multiple gene targets in order to compress RNA interference (RNAi) screen size. Before investigating the practical use of this strategy, we first characterized the gene-specific RNAi induced by a large subset (258 siRNAs, 129 genes) of the entire siRNA library used in this study ( approximately 800 siRNAs, approximately 400 genes). We next demonstrated that multiplexed siRNAs could silence at least six genes to the same degree as when the genes were targeted individually. The entire library was then used in a screen in which randomly multiplexed siRNAs were assayed for their affect on cell viability. Using this strategy, several gene targets that influenced the viability of a breast cancer cell line were identified. This study suggests that the screening of randomly multiplexed siRNAs may provide an important avenue towards the identification of candidate gene targets for downstream functional analyses and may also be useful for the rapid identification of positive controls for use in novel assay systems. This approach is likely to be especially applicable where assay costs or platform limitations are prohibitive.
Response of piezoresistive MEMS accelerometers and pressure transducers to high gamma dose (2003)

Several piezoresistive microelectromechanical (MEMS) sensors are operated in a gamma ray environment to doses of 800 kGy. The pressure transducers and accelerometers are micromachined silicon-on-insulator (SOI) and bulk silicon devices, respectively. Both sensor types experienced similar performance degradation: a drift in offset voltage with a slight increase in sensitivity. We explain the drift in offset voltage for all sensors tested by correlating the change in resistance of the silicon piezoresistors to the formation of oxide and interface trapped hole charges. We demonstrate how these charges effectively reduce the volume for current flow through the piezoresistors due to the creation of a depletion region surrounding the periphery of the gage resistors. Differences in the magnitude of the output voltage drift of the two sensor types are determined to be related to the unique construction of each sensor.
Eco-friendly synthesis of graphene nanoplatelets (2016)

In this feature article, we summarize the general aspects and recent progress that have contributed to the development of eco-friendly green synthesis procedures for graphene, including mechanisms, properties, and applications.
A Lightweight and Discriminative Model for Remote Sensing Scene Classification With Multidilation Pooling Module (2019)

With the growing spatial resolution of satellite images, high spatial resolution (HSR) remote sensing imagery scene classification has become a challenging task due to the highly complex geometrical structures and spatial patterns in HSR imagery. The key issue in scene classification is how to understand the semantic content of the images effectively, and researchers have been looking for ways to improve the process. Convolutional neural networks (CNNs), which have achieved amazing results in natural image classification, were introduced for remote sensing image scene classification. Most of the researches to date have improved the final classification accuracy by merging the features of CNNs. However, the entire models become relatively complex and cannot extract more effective features. To solve this problem, in this paper, we propose a lightweight and effective CNN which is capable of maintaining high accuracy. We use MobileNet V2 as a base network and introduce the dilated convolution and channel attention to extract discriminative features. To improve the performance of the CNN further, we also propose a multidilation pooling module to extract multiscale features. Experiments are performed on six datasets, and the results verify that our method can achieve higher accuracy compared to the current state-of-the-art methods.
The photochemistry of benzobarrelene. Mechanistic and exploratory photochemistry. XXXV (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe photochemistry of benzobarrelene. Mechanistic and exploratory photochemistry. XXXVHoward E. Zimmerman, Richard S. Givens, and Richard M. PagniCite this: J. Am. Chem. Soc. 1968, 90, 22, 6096–6108Publication Date (Print):October 1, 1968Publication History Published online1 May 2002Published inissue 1 October 1968https://pubs.acs.org/doi/10.1021/ja01024a029https://doi.org/10.1021/ja01024a029research-articleACS PublicationsRequest reuse permissionsArticle Views502Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
NEW YORK ACADEMY OF MEDICINE, SECTION OF DERMATOLOGY AND SYPHILOLOGY (1958)

<b>Tertiary Syphilis. (1) Aneurysm of the Ascending Aorta with Occlusion of the Superior Vena Cava (Partial) and Compression of Right Pulmonary Artery; (2) Gumma of Forehead; (3) Tabes Dorsalis.</b>Presented byDr. Leslie P. Barker. From: Vanderbilt Clinic and Presbyterian Hospital. Patient: Woman aged 50. Complaint: Vomiting of two days' duration. History: Patient had episodes of vomiting two days, two weeks, and two months before admission. She was taken to another hospital where a routine chest film showed a large mediastinal mass, and she was transferred to Presbyterian Hospital for further study. She has had an asymptomatic eruption of the forehead for six weeks. There have been no cardiorespiratory symptoms. General health has been good. Thirty years ago she had a positive blood and negative spinal fluid test. There is no history of treatment. She has had three normal pregnancies; her children are living and well. Their serologies
Bioassay-Guided Fractionation of<i>Rubus suavissimus</i>. Leaf Extracts Possessing NF-<i>κ</i>.B Inhibitory Activities and a Separable Cytotoxicity (2005)

Leaf extract of Rubus suavissimus. S. Lee (Rosaceae), a perennial woody shrub indigenous to southern China, was tested for its biological activity in the regulation of transcription factor NF-κ.B (nuclear factor kappa B) A NF-κ.B luciferase reporter cell line was used in this study. The crude extract inhibited NF-κ.B at 100–1000 µg/ml concentrations with minor cytotoxicity. This finding prompted two more rounds of fractionation toward separating the active fraction from the cytotoxic fraction. Five fractions were obtained in the first round of fractionation, of which RUS-C20 was found to be the most potent in inhibiting NF-κ.B without signs of cytotoxicity up to 1000 µg/ml concentration. Fraction RUS-C100 showed little inhibition to NF-κ.B and apparent cytotoxicity. Further fractionation of RUS-C20, using Sephadex LH-20 chromatography, resulted in three subfractions that were distinct in chemical constituents as determined by their retention times and UV absorption spectra of each component. NF-κ.B reporter assay indicated that one of the three subfractions of RUS-C20 retained the inhibitory activity, whereas the other two subfractions were inactive. Bioassay-guided fractionation led to a successful separation of efficacy from cytotoxicity and identification of active components. This warrants further isolation for a purified single compound, which can be used as the chemical marker to standardize the extract for inhibition of NF-κ.B.
Density of metastable atoms in an argon plasma produced by an RF surface wave (1977)

The maximum density of argon atoms in excited metastable states, in a plasma produced by surface wave propagation, is studied experimentally. Measurements are performed by the absorption method, perpendicularly to the tube axis. The measurements show that the maximum population densities of the 3p 5 4s metastable levels in argon are larger in the RF plasma than in the positive column of a glow discharge, between 0.02 and 0.4 Torr in a 26 mm i.d. tube. This fact could be used to improve gas laser operation.
Synthesis, characterization, and polymerization of brominated benzoxazine monomers and thermal stability/flame retardance of the polymers generated (2009)

Abstract Novel monofunctional brominated benzoxazine 3‐(2,4,6‐tribromophenyl)‐3,4‐dihydro‐2H‐1,3‐benzoxazine (P‐bra) and bifunctional brominated benzoxazine 6,6′‐bis(3‐(2,4,6‐tribromophenyl)‐3,4‐dihydro‐2H‐1,3‐benzoxazinyl) isopropane (B‐bra) were prepared and highly thermally stable polybenzoxazines were obtained by the thermal cure of the corresponding benzoxazines monomers. The chemical structures of these novel monomers were confirmed by FITR, 1 H‐NMR and elemental analysis. FTIR spectra and differential scanning calorimetry (DSC) suggested that the polymerization was thermally initiated and occurred via ring‐opening of the monomer in each case. Thermogravimetric analysis (TGA) indicated that brominatation could have a profound effect on increasing char yield and on thermal degradation temperatures. The results of UL‐94 burn test showed that the polybenzoxazines prepared from P‐bra and B‐bra had good flame retardance. Copyright © 2009 John Wiley & Sons, Ltd.
Efficient and accurate modeling of power supply noise on distributed on-chip power networks (2002)

In this paper, we propose an efficient and accurate modeling technique for power supply noise estimation over on-chip power lines which are modeled as distributed RCL networks. With this model, peak noise on the power lines that includes on-chip resistive and inductive voltage drops, switching noise on packages, and on-chip decoupling effects, can be computed very efficiently and accurately. The model is verified by SPICE simulations.
ChemInform Abstract: PREPARATION, STRUCTURE AND REACTIVITY OF HIGHLY SUBSTITUTED PORPHYRINS (1976)

Abstract Knoevenage1‐ Kondensation des Porphyrinaldehyds (I) mit den Malonsäureverbindungen (II) gibt die Acrylsäurederivate (III); durch Hydrierung von (IIIb) bzw. (IIId) (hierbei unter gleichzeitiger Decarboxylierung) entstehen die Derivate (IV), durch Hydrierung von (IIIa) wird dagegen das Vinylderivat (V) erhalten.