gebhart/patrepeval huggingface dataset:
ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types (2016)

Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive cancer types and the leading cause of cancer-associated deaths. The EMT-inducing transcriptional repressor ZEB1 is a crucial stimulator of these processes, particularly by coupling the activation of cellular motility with stemness and survival properties. ZEB1 expression is associated with aggressive behaviour in many tumour types, but the potent effects cannot be solely explained by its proven function as a transcriptional repressor of epithelial genes. Here we describe a direct interaction of ZEB1 with the Hippo pathway effector YAP, but notably not with its paralogue TAZ. In consequence, ZEB1 switches its function to a transcriptional co-activator of a 'common ZEB1/YAP target gene set', thereby linking two pathways with similar cancer promoting effects. This gene set is a predictor of poor survival, therapy resistance and increased metastatic risk in breast cancer, indicating the clinical relevance of our findings.
Amino Ketone Rearrangements. VI. Synthesis of 2-Alkylamino-2-phenylcyclohexanones<sup>1a</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmino Ketone Rearrangements. VI. Synthesis of 2-Alkylamino-2-phenylcyclohexanones1aCalvin L. Stevens, Arthur B. Ash, Andre Thuillier, J. H. Amin, Aldona Balys, William E. Dennis, James P. Dickerson, Ronald P. Glinski, Harry T. Hanson, Muriraj D. Pillai, and John W. StoddardCite this: J. Org. Chem. 1966, 31, 8, 2593–2601Publication Date (Print):August 1, 1966Publication History Published online1 May 2002Published inissue 1 August 1966https://pubs.acs.org/doi/10.1021/jo01346a033https://doi.org/10.1021/jo01346a033research-articleACS PublicationsRequest reuse permissionsArticle Views708Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Effects of interferon on various malignancies]. (1984)

This paper over-viewed the clinical studies on various interferons including HLBI (human lymphoblastoid interferon), HuIFN-beta (human fibroblast interferon) and r-IFN-alpha A (recombinant leukocyte A interferon) which have been tried widely in Japan. These interferons have shown some antitumor effects on various malignancies such as malignant lymphoma, multiple myeloma, renal cell carcinoma, leukemias, brain tumors, malignant melanoma, mycosis fungoides and others. Adverse reactions included fever, general fatigue, leukopenia and thrombocytopenia, and abnormal liver function tests were experienced.
Activity–stability relationship in the surface electrochemistry of the oxygen evolution reaction (2014)

Understanding the functional links between the stability and reactivity of oxide materials during the oxygen evolution reaction (OER) is one key to enabling a vibrant hydrogen economy capable of competing with fossil fuel-based technologies. In this work, by focusing on the surface chemistry of monometallic Ru oxide in acidic and alkaline environments, we found that the kinetics of the OER are almost entirely controlled by the stability of the Ru surface atoms. The same activity-stability relationship was found for more complex, polycrystalline and single-crystalline SrRuO(3) thin films in alkaline solutions. We propose that the electrochemical transformation of either water (acidic solutions) or hydroxyl ions (alkaline solutions) to di-oxygen molecules takes place at defect sites that are inherently present on every electrode surface. During the OER, surface defects are also created by the corrosion of the Ru ions. The dissolution is triggered by the potential-dependent change in the valence state (n) of Ru: from stable but inactive Ru(4+) to unstable but active Ru(n>4+). We conclude that if the oxide is stable then it is completely inactive for the OER. A practical consequence is that the best materials for the OER should balance stability and activity in such a way that the dissolution rate of the oxide is neither too fast nor too slow.
The brighter side of soils: Quantum dots track organic nitrogen through fungi and plants (2009)

Soil microorganisms mediate many nutrient transformations that are central in terrestrial cycling of carbon and nitrogen. However, uptake of organic nutrients by microorganisms is difficult to study in natural systems. We assessed quantum dots (fluorescent nanoscale semiconductors) as a new tool to observe uptake and translocation of organic nitrogen by fungi and plants. We conjugated quantum dots to the amino groups of glycine, arginine, and chitosan and incubated them with Penicillium fungi (a saprotroph) and annual bluegrass (Poa annua) inoculated with arbuscular mycorrhizal fungi. As experimental controls, we incubated fungi and bluegrass samples with substrate-free quantum dots as well as unbound quantum dot substrate mixtures. Penicillium fungi, annual bluegrass, and arbuscular mycorrhizal fungi all showed uptake and translocation of quantum dot-labeled organic nitrogen, but no uptake of quantum dot controls. Additionally, we observed quantum dot-labeled organic nitrogen within soil hyphae, plant roots, and plant shoots using field imaging techniques. This experiment is one of the first to demonstrate direct uptake of organic nitrogen by arbuscular mycorrhizal fungi.
Efficient Source Separation Algorithms for Acoustic Fall Detection Using a Microsoft Kinect (2014)

Falls have become a common health problem among older adults. In previous study, we proposed an acoustic fall detection system (acoustic FADE) that employed a microphone array and beamforming to provide automatic fall detection. However, the previous acoustic FADE had difficulties in detecting the fall signal in environments where interference comes from the fall direction, the number of interferences exceeds FADE's ability to handle or a fall is occluded. To address these issues, in this paper, we propose two blind source separation (BSS) methods for extracting the fall signal out of the interferences to improve the fall classification task. We first propose the single-channel BSS by using nonnegative matrix factorization (NMF) to automatically decompose the mixture into a linear combination of several basis components. Based on the distinct patterns of the bases of falls, we identify them efficiently and then construct the interference free fall signal. Next, we extend the single-channel BSS to the multichannel case through a joint NMF over all channels followed by a delay-and-sum beamformer for additional ambient noise reduction. In our experiments, we used the Microsoft Kinect to collect the acoustic data in real-home environments. The results show that in environments with high interference and background noise levels, the fall detection performance is significantly improved using the proposed BSS approaches.
Free computational resources for designing selected reaction monitoring transitions (2010)

Selected reaction monitoring (SRM) is a technique for quantifying specific proteins using triple quadrupole MS. Proteins are digested into peptides and fed into MS following HPLC separation. The stream of ionized peptides is filtered by m/z ratio so only specific peptide targets enter the collision cell, where they are fragmented into product ions. A specific product ion is then filtered from the cell and its intensity measured. By spiking an isotopically labeled version of each target peptide into a sample, both native and surrogate peptides enter MS, pass the filters and transition into product ions in tandem; thus the quantity of the native peptide may be calculated by examining the relative intensities of the native and surrogate signals. The choice of precursor-to-product ion transitions is critical for SRM, but predicting the best candidates is challenging and time-consuming. To alleviate this problem, software tools for designing and optimizing transitions have recently emerged, predominantly driven by data from public proteomics repositories, such as the Global Proteome Machine and PeptideAtlas. In this review, we provide an overview of the state-of-the-art in automated SRM transition design tools in the public domain, explaining how the systems work and how to use them.
Evaluating Laplace Noise Addition to Satisfy Differential Privacy for Numeric Data (2011)

Abstract. Laplace noise addition is often advanced as an approach for satisfying differ-‐‑ ential privacy. There have been several illustrations of the application of Laplace noise addition for count data, but no evaluation of its performance for numeric data. In this study we evaluate the privacy and utility performance of Laplace noise addition for numeric data. Our results indicate that Laplace noise addition delivers the promised level of privacy only by adding a large quantity of noise for even relatively large sub-‐‑ sets. Because of this, even for simple mean queries, the responses for a masking mecha-‐‑ nism that uses Laplace noise addition is of little value. We also show that Laplace noise addition may be vulnerable to a tracker attack. In order to avoid this, it may be neces-‐‑ sary to increase the variance of the noise added as a function of the number of queries issued. This implies that the utility of the responses would be further reduced. These results raise serious questions regarding the viability of Laplace based noise addition for masking numeric data. 1
Flammability of Endotracheal Tubes in Oxygen and Nitrous Oxide Enriched Atmosphere (1987)

Endotracheal tube (ETT) fire has been reported secondary to laser and electrocautery ignition. The flammability of polyvinylchloride (PVC), silicone (Si), and red rubber (RR) ETTs in oxygen (O2) and/or nitrous oxide (N2O) in nitrogen was determined and compared by means of the O2 and N2O indices of flammability. The O2 index of flammability is the minimum O2 fraction in nitrogen that will support candle-like flame using a standard ignition source. The O2 index of flammability for PVC ETTs is 0.263, for Si 0.189, and for RR 0.176. The N2O index of flammability is the minimum N2O fraction in N2 that will support candle-like flame using a standard ignition source. The N2O index of flammability for PVC ETTs is 0.456, for Si ETTs 0.414, and for RR ETTs 0.374. The indices are additive. Flammability is a valid method of comparing safety of various endotracheal tube materials. There is a need for new endotracheal tube material with a higher index of flammability. The significance of these findings and the clinical applications are discussed.
Increased Leaf Angle1, a Raf-Like MAPKKK That Interacts with a Nuclear Protein Family, Regulates Mechanical Tissue Formation in the Lamina Joint of Rice  (2011)

Mitogen-activated protein kinase kinase kinases (MAPKKKs), which function at the top level of mitogen-activated protein kinase cascades, are clustered into three groups. However, no Group C Raf-like MAPKKKs have yet been functionally identified. We report here the characterization of a rice (Oryza sativa) mutant, increased leaf angle1 (ila1), resulting from a T-DNA insertion in a Group C MAPKKK gene. The increased leaf angle in ila1 is caused by abnormal vascular bundle formation and cell wall composition in the leaf lamina joint, as distinct from the mechanism observed in brassinosteroid-related mutants. Phosphorylation assays revealed that ILA1 is a functional kinase with Ser/Thr kinase activity. ILA1 is predominantly resident in the nucleus and expressed in the vascular bundles of leaf lamina joints. Yeast two-hybrid screening identified six closely related ILA1 interacting proteins (IIPs) of unknown function. Using representative IIPs, the interaction of ILA1 and IIPs was confirmed in vivo. IIPs were localized in the nucleus and showed transactivation activity. Furthermore, ILA1 could phosphorylate IIP4, indicating that IIPs may be the downstream substrates of ILA1. Microarray analyses of leaf lamina joints provided additional evidence for alterations in mechanical strength in ila1. ILA1 is thus a key factor regulating mechanical tissue formation at the leaf lamina joint.
Developmental regulation of the sheep β‐lactoglobulin gene in the mammary gland of transgenic mice (1991)

beta-Lactoglobulin (BLG) is the most abundant whey protein in sheep milk but it is not present in mouse milk. We have previously shown that transgenic mice carrying the BLG gene express it specifically in the mammary gland and secrete BLG into milk at high concentrations. Here we demonstrate that BLG transcription is correctly initiated in mice and that BLG synthesis is restricted to the secretory epithelial cells of the mammary gland. We have also determined the temporal pattern of milk protein gene expression and find that the BLG transgene is regulated coordinately with mouse beta-casein and that the patterns of regulation of BLG in mouse and sheep share some similarities.
Intrinsic graphene/metal contact (2012)

This paper presents our recent understanding of metal/graphene contact in terms of intrinsic interface obtained from the comparison between resist-free and conventional EB processes, and discusses future challenges to reduce the contact resistivity.
Novel Perspective: Focusing on the X Chromosome in Reproductive Cancers (2003)

In an XX female, one of the two X chromosomes has been inactivated during early embryonic life to achieve a compensation of X-linked gene products between males and females, leaving only one allele of X-linked genes functional. There are some X-linked genes escaping the X-inactivation, i.e., being expressed from both alleles. Escape from X-inactivation varies at different levels; some genes have both alleles active in some women but only one allele active in others, whereas some other genes have both alleles active in neoplastic tissue but only one allele active normally. The X-inactivation may be considered functionally equivalent to a loss of heterozygosity (LOH) for some genes, whereas escape from X-inactivation may be equivalent to functional gene amplification for others. The physiological LOH may make X-linked tumor suppressor genes lose their function more easily, compared with autosomal tumor suppressor genes, thus predisposing women to cancer formation more easily. Moreover, the human X chromosome contains many genes related to cancer or to sex and reproduction. All these properties of the X chromosome suggest that it may play more important roles than any autosomal chromosome in the development and progression of reproductive and urologic cancers.
The nature and extent of Eriophyes vitis injury to Vitis vinifera L. (1963)

Eriophyes vitis, feeding on embryonic tissue of grape buds or shoots, causes hypertrophy of the cells fed upon and later, the formation of scar tissue. This injury, when extensive, results in malformation of the maturing structure. Other organisms or conditions interfering with the normal maturation of tissue may account for deformations similar to those produced by E. vitis feeding. The possibility of economie losses due to E. vitis is normally minimized by the propensity for the mites to feed primarily on the scales of overwintering buds and by the reduction of their numbers on new shoot growth by factors such as predation and possibly climate. E. vitis injury in commercial Tokay vineyards which were studied did not cause a commercial loss, However the effect on vine in the shoots sufficient to cause boron toxicity symptoms had little or no adverse effect on mite populations. 2) Mites were able to cause typical injury to shoots with high as weil as low boron content. 3) The symptoms produced by the mites were distinct from those produced by boron excess. The classic symptoms of boron excess syndrome were identified by Dr. J. A. Cook, and the syndrome of mite injury was identified by the authors.
Effect of electronegative substituents on the reductive dimerization of Schiff bases. Formation of vicinal dianions (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of electronegative substituents on the reductive dimerization of Schiff bases. Formation of vicinal dianionsJames G. Smith and Isaac HoCite this: J. Org. Chem. 1973, 38, 16, 2776–2779Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August 1973https://pubs.acs.org/doi/10.1021/jo00956a008https://doi.org/10.1021/jo00956a008research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The CMP Process and Cleaning Solution for Planarization of Strain-Relaxed SiGe Virtual Substrates in MOSFET Applications (2006)

The effects of different polishing pads and slurry solid contents on the SiGe chemical mechanical polish (CMP) process were investigated. By optimizing the polishing conditions, a smooth strained-Si surface on a flattened buffer layer of can be achieved. The novel cleaning solutions with various surfactants and chelating agents for post-CMP SiGe were studied. There was about 10% current enhancement of the optimal cleaning conditions, showing high performance in particle removal, metallic cleaning, and electrical characteristics.
BAS1 Has a Myb Motif and Activates <i>HIS4</i> Transcription Only in Combination with BAS2 (1989)

The BAS1 and BAS2 proteins are both required for activation of GCN4-independent (basal) HIS4 transcription in yeast. BAS1 has an NH2-terminal region similar to those of the myb proto-oncogene family. BAS1 and BAS2, which contains a homeo box, bound to adjacent sites on the HIS4 promoter. The joint requirement of BAS1 and BAS2 for activation is probably not due to cooperative binding or the transcriptional control of one of the genes by the other. Although BAS1 and BAS2 were both required for activation of HIS4 transcription, BAS1 was not required for BAS2-dependent expression of the secreted acid phosphatases. The transcriptional activators of HIS4 have DNA binding domains that are conserved in evolution (BAS1 = Myb, BAS2 = homeo box, GCN4 = Jun). Their interactions, therefore, may be relevant to the control of gene expression in more complex systems.
Stability of amphotericin B 0.05 and 0.5 mg/mL in 20% fat emulsion (1997)

Journal Article Stability of amphotericin B 0.05 and 0.5 mg/mL in 20% fat emulsion Get access Dwight Owens, PHARM.D., Dwight Owens, PHARM.D. Director of Pharmacy Northeast Tennessee Rehabilitation Center, Johnson City; at the time of this study he was Pharmacy Resident, Department of Pharmacy, North Carolina Baptist Hospitals, Inc. (NCBH), Winston-Salem Search for other works by this author on: Oxford Academic Google Scholar Ronald A. Fleming, PHARM.D., Ronald A. Fleming, PHARM.D. Assistant Professor Section on Hematology/ Oncology, Department of Internal Medicine, Bowman Gray School of Medicine (BGSM), Winston-Salem Address reprint requests to Dr. Fleming at the Section on Hematology/Oncology, Department of Internal Medicine, Bowman Gray School of Medicine, Medical Center Boulevard, Winston- Salem, NC 27157, or to. Search for other works by this author on: Oxford Academic Google Scholar Maryann S. Restino, PHARM.D., Maryann S. Restino, PHARM.D. Assistant Director Pharmaceutical Care Services and Resource Development, Department of Pharmacy, NCBH Search for other works by this author on: Oxford Academic Google Scholar Julia M. Cruz, M.D., Julia M. Cruz, M.D. Associate Professor Section on Hematology/ Oncology, Department of Internal Medicine, BGSM Search for other works by this author on: Oxford Academic Google Scholar David D. Hurd, M.D. David D. Hurd, M.D. Professor Section on Hematology/Oncology, Department of Internal Medicine, BGSM, and Director, Bone Marrow Transplant Program, NCBH Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 54, Issue 6, 15 March 1997, Pages 683–686, https://doi.org/10.1093/ajhp/54.6.683 Published: 15 March 1997
Corporate Networking Applications (1991)

Digital connectivity and Integrated Services Digital Network (ISDN) functionalities offer ways to bring new voice, data, and video applications to corporate network users. ISDN virtual private networks allow both small and large corporations to offer these applications to their users. Corporate network telephone users can have station and messaging features that were previously available only to users on the same private branch exchange (PBX). Remote access to centralized computers from personal computers (PCs), and computing resources associated with local area networks (LANs), are now available over digital corporate networks. Videoconferences can be arranged on demand on corporate networks between domestic and international locations. This paper describes current applications of modern corporate networks, and discusses some emerging applications that can be realized by ISDN.