gebhart/patrepeval huggingface dataset:
Thyroid Function Disturbance and Type 3 Iodothyronine Deiodinase Induction after Myocardial Infarction in Rats—A Time Course Study (2007)

In humans, there is a significant decrease in serum T(3) and increase in rT(3) at different time points after myocardial infarction, whereas serum TSH and T(4) remain unaltered. We report here a time course study of pituitary-thyroid function and thyroid hormone metabolism in rats subjected to myocardial infarction by left coronary ligation (INF). INF- and sham-operated animals were followed by serial deiodination assays and thyroid function tests, just before, and 1, 4, 8, and 12 wk after surgery. At 4 and 12 wk after INF, liver type 1 deiodinase activity was significantly lower, confirming tissue hypothyroidism. Type 3 deiodinase (D3) activity was robustly induced 1 wk after INF only in the infarcted myocardium. Reminiscent of the consumptive hypothyroidism observed in patients with large D3-expressing tumors, this induction of cardiac D3 activity was associated with a decrease in both serum T(4) ( approximately 50% decrease) and T(3) (37% decrease), despite compensatory stimulation of the thyroid. Thyroid stimulation was documented by both hyperthyrotropinemia and radioiodine uptake. Serum TSH increased by 4.3-fold in the first and 3.1-fold in the fourth weeks (P < 0.01), returning to the basal levels thereafter. Thyroid sodium/iodide-symporter function increased 1 wk after INF, accompanying the increased serum TSH. We conclude that the acute decrease in serum T(4) and T(3) after INF is due to increased thyroid hormone catabolism from ectopic D3 expression in the heart.
Mycosis fungoides—a disease of antigen persistence (1974)

The function of B- and T-lymphocytes in nineteen patients with classical Alibert's mycosis fungoides (MF) was studied. In general there was no evidence of immune depression, not even in those with the disease for many years. The distribution of B-cells in the peripheral blood was normal. No immunoglobulin- bearing lymphocytes were detected in freshly liberated cells from the skin lesions or on direct immunofluorescence microscopy of those lesions. Serum IgE levels were significantly elevated, even though only two of the patients were atopic. ‘Auto-antibodies’ were detected in thirteen patients. Two cases of malignant lymphoma and one of Sézary syndrome contrasted strikingly with the mycosis fungoides (MF) group. Our findings support the hypothesis that mycosis fungoides (MF) is a chronic granulomatous response to persistent unidentified antigen(s), upon which immune imbalance can develop resulting in ‘auto-immune’ phenomena and, in a few cases, the emergence of various lymphoreticular neoplasms.
Determination of sodium hyaluronate with some basic bisphenylnaphthylmethane dyes by resonance Rayleigh scattering method (2007)

In an acetic acid-sodium acetate buffer solution ofpH 3.6-6.8,a compound complex was formed between sodium hyaluronate (abbreviated as SH)and some basic bisphenylnaphthylmethane dyes,leading to a great enhancement of the intensity of resonance Rayleigh scattering(RRS)and giving a new RRS spectrum,with its maximum scattering peak near 280 um.It was also found that the intensity of RRS was directly proportional to the concentration of SH near the range between 0 and 3.0 mg/L.Based on these facts,a sensitive method for the determination of SH has been established.The method had good selectivity,and has been used for the determination of total amounts of SH in samples with satisfactory results.For the NB-SH system,the detection limit of SH was down to 13.7 ng/mL.
Complicated forms of autosomal dominant hereditary spastic paraplegia are frequent in SPG10 (2008)

Hereditary spastic paraplegias (HSP) constitute a heterogeneous group of neurodegenerative disorders characterized by slowly progressive spasticity of the lower extremities. Only a few different mutations in the SPG10 gene, KIF5A, have been described in pure dominant forms of the disease. We sequenced the motor domain of KIF5A in a large panel of 205 European HSP patients with either pure or complicated forms of the disease. We identified eight different heterozygous missense mutations, seven novels, in eight different families of French origin. Residue R280 was a mutational hot spot. Interestingly, the patients in 7/8 families had a complex phenotype, with peripheral neuropathy, severe upper limb amyotrophy (Silver syndrome-like), mental impairment, parkinsonism, deafness and/or retinitis pigmentosa as variably associated features. We report the largest series of SPG10 families described so far, which extends both the mutational spectrum of the disease and its phenotype, which now includes complicated forms of HSP. SPG10 mutations were found in 10% of our complicated forms of HSP, suggesting that mutations in KIF5A represent the major cause of complicated AD-HSP in France.
Acidities of Some Substituted Ammonium Ions in Dimethyl Sulfoxide† (1997)

pK a Values in DMSO are reported for ammonium ions derived from amines which have previously been widely used as nucleophiles in nucleophilic aromatic substitution reactions; values are also given for four polynitrodiphenylamines used as indicators.
Sir Thomas Malory, M.P (1974)

Journal Article Sir Thomas Malory, M.P Get access P. J. C. Field P. J. C. Field Search for other works by this author on: Oxford Academic Google Scholar Bulletin of the Institute of Historical Research, Volume 47, Issue 115, May 1974, Pages 24–35, https://doi.org/10.1111/j.1468-2281.1974.tb02179.x Published: 12 October 2007
VR is on the Edge (2017)

VR/AR is rapidly progressing towards enterprise and end customers with the promise of bringing immersive experience to numerous applications. Soon it will target smartphones from the cloud and 360° video delivery will need unprecedented requirements for ultra-low latency and ultra-high throughput to mobile networks. Latest developments in NFV and Mobile Edge Computing reveal already the potential to enable VR streaming in cellular networks and to pave the way towards 5G and next stages in VR technology.
Designing robust watermark barcodes for multiplex long-read sequencing (2016)

A method for designing sequencing barcodes that can withstand a large number of insertion, deletion and substitution errors and are suitable for use in multiplex single-molecule real-time sequencing is presented. The manuscript focuses on the design of barcodes for full-length single-pass reads, impaired by challenging error rates in the order of 11%. To the authors' knowledge, this is the first method to specifically address this problem without requiring upstream quality improvement. The proposed barcodes can multiplex hundreds or thousands of samples while achieving sample misassignment probabilities as low as $10^{-7}$, and are designed to be compatible with chemical constraints imposed by the sequencing process. Software for constructing watermark barcode sets and demultiplexing barcoded reads, together with example sets of barcodes and synthetic barcoded reads, are freely available at www.cifasis-conicet.gov.ar/ezpeleta/NS-watermark.
An evaluation of nerve repair with nerve allografts in normal and immunologically tolerant rats (1980)

Schwann cells survive longer in allografts of ganglia that contain minor, rather than major and minor, transplantation antigens. The authors have investigated whether a nerve allograft with minor antigens would be superior to one with major and minor incompatibilities in aiding in the repair of injured nerve. A segment of host peroneal nerve was removed from rats and replaced with a peroneal nerve allograft that contained either minor or major and minor antigens. The results showed that in normal rats, host nerve fibers could functionally regenerate through (that is, grow through and reinnervate muscle) nerve allografts 2 cm but not 4 cm in length, irrespective of the antigens the allografts contained. Host nerve fibers could, however, regenerate through 4-cm nerve allografts if the hosts were rendered immunologically tolerant of the transplantation antigens of the nerve donors. Furthermore, when sensitized lymphoid cells were injected into tolerant rats bearing functional nerve allografts, Schwann cell rejection and demyelination occurred in the graft but host nerve fibers remained. It is concluded that minor antigens alone are as potent as major and minor antigens together in evoking an immune response that prevents functional regeneration through long lengths of nerve allografts. Host nerve fibers can, however, regenerate through such nerve allografts if the hosts are immunosuppressed.
Phase-Changing Sacrificial Layer Fabrication of Multilayer Polymer Microfluidic Devices (2007)

We present a new approach for fabricating multilayer microfluidic devices in poly(methyl methacrylate). Paraffin wax was used as a phase-changing sacrificial layer to protect microstructures during solvent bonding. Microchannels in the top and bottom pieces were aligned with through-holes in the middle layer, resulting in microchannels that cross one another. No discernible delamination of the layers or leakage between channels was observed at pressures as high as 300 psi. The current versus voltage linearity in the crossover channel indicates that no Joule heating occurs at voltages of at least 2.0 kV. Moreover, a potential in the crossover channel did not affect the current in the separation channel. Rapid and efficient separation of fluorescently labeled amino acids was performed in these devices. Pressurized buffer flow or voltage applied in the crossover channel caused no leakage into or electrical interference with the separation channel. Our results demonstrate that sacrificial layers with solvent bonding can be implemented readily in the fabrication of robust and fluidically complex multilayer polymer microchips. These capabilities should facilitate the development of a new generation of sophisticated microfluidic systems.
A BSN Faculty Responds: Is Promotion Really the Issue? (1988)

Elizabeth A. Peterson, RN, MS, is an assistant professor of nursing at Bethel College and a psychotherapist with Associated Resources in Psychology in St. Paul, Minnesota. Previously she worked as a staff nurse on medical and psychiatric units.
Secretion of beta-lactamase into the periplasm of Escherichia coli: evidence for a distinct release step associated with a conformational change. (1986)

The secretion of beta-lactamase (EC 3.5.2.6) into the periplasm of Escherichia coli has been followed by pulse-chase labeling at 15 degrees C. Though the periplasmic fraction contains only the mature form of the enzyme, the spheroplast fraction contains the completed precursor and a hitherto undocumented processed form. When whole spheroplasts are treated with trypsin, the processed form in this fraction is completely digested. This is in contrast to the native mature enzyme localized in the periplasm, which is trypsin resistant. The beta-lactamase is evidently processed after translocation to a trypsin-sensitive form that is transiently bound to the periplasmic face of the inner membrane. The release of this processed form into the periplasm occurs concomitantly with a conformational change that results in the soluble, catalytically active, trypsin-resistant structure.
Phase I Clinical Trial in Cancer Patients of a New Monoclonal Antibody FC-2.15 Reacting with Tumor Proliferating Cells (1995)

FC-2.15 is a new murine IgM monoclonal antibody (MAb) that recognizes previously undescribed antigens present in proliferating breast cancer cells and normal peripheral granulocytes. A phase I clinical trial was performed in 11 patients with advanced cancer (breast, 5; colon, 2; melanoma, 1; lung, 1; medullary thyroid, 1; skin squamous carcinoma, 1). FC-2.15 was administered by i.v. infusion every other day; eight patients received four infusions, two patients three infusions and one patient received two infusions. One patient received two cycles of treatment. Total doses of MAb ranged between 2.5 and 5 mg/kg. Maximal FC-2.15 serum concentrations for different patients ranged between 1.3 and 7.5 micrograms/ml, and the serum half-life (t1/2-alpha) was approximately 7-9 h. All patients developed human anti-murine antibody. The most consistent toxicity (10 of 11 patients) was a profound and selective neutropenia that occurred within 1 h after the start of each infusion and reversed within 1 h after its discontinuation. Other frequent side effects included fever and chills that were easily manageable. Only two patients needed dose reduction or treatment interruption. The patient who received two treatment cycles did not develop allergic reactions. An objective partial response, consisting of a sustained (4 months) > 50% reduction of breast carcinoma liver metastases, was observed.
Random laser action in ZnO doped polymer (2006)

We report on random lasing action in zinc oxide microparticles dispersed in organic disordered hybrid polymer. Lasing action from zinc-oxide–polymer hybrid is reported at temperature ranging from 6to250K. Coherent backscattering measurements reveal that the transport of light in the sample is diffusive and feedback for lasing is incoherent. The zinc oxide particles provide both the gain and the scattering whereas polymer matrix offers ease of material fabrication.
Clinical Engineering Development in China (2011)

In Brief Among the many evolving things in our world, perhaps the combination of the development of organized knowledge, focused networking, applied practices, and recognized minimum levels of competency are the common elements of professional associations, especially in the context of rapidly growing systems. The adoption of these elements is the reason that the Chinese Clinical Engineering Society is rapidly growing in the size of its membership, the scope of services it offers, and in representing their constituents to other societies and coworkers in the healthcare delivery industry. This article describes the evolution of clinical engineering in China and the recent activities of this association. Among the many evolving things in our world, perhaps the combination of the development of organized knowledge, focused networking, applied practices, and recognized minimum levels of competency are the common elements of professional associations, especially in the context of rapidly growing systems. The adoption of these elements is the reason that the Chinese Clinical Engineering Society is rapidly growing in the size of its membership, the scope of services it offers, and in representing their constituents to other societies and coworkers in the healthcare delivery industry. This article describes the evolution of clinical engineering in China and the recent activities of this association.
Explosion waves and shock waves Part II—The shock wave and explosion products sent out by blasting detonators (1935)

Abstract The detonation of a cartridge of a high explosive is started by firing a detonator, which consists of a small metal cylinder containing a compound or mixture which is itself readily detonated when it is heated. The manner in which detonators thus function is not thoroughly understood, and the methods used for measuring their "efficiency" are, in consequence, diverse. By some methods only the total blow given by the detonator, or its crushing and shattering effect, is measured; the nail test and sand test are the crudest forms. The lead plate test gives a similar measure, and the efficiency of a detonator is judged not only by the depth of the impression produced, but also by the number and appearance of radial grooves in the lead plate produced by the disrupted metal casing. More precise physical methods have been adopted, such as the Hopkinson pressure-bar, which gives a measure of the time of action of the impulsive blow. A more logical method of measurement of efficiency would appear to be a examine the ease with which the detonator will set up detonation in a standard explosive or in a series of standard explosives. Such a method is the Esop test, in which measurement is made of the maximum amount of olive or cotton seed oil which can be mixed with picric acid without preventing its detonation by the detonator embedded in the mixture. Of the same type is the gap test, in which the detonator and a standard explosive are separated and the maximum distance is measured at which detonation of the explosive can be established. The efficiency of a detonator is of considerable technical importance. The more rapidly a detonator can set up detonation in a cartridge of explosive the greater will be the proportion of the cartridge which will detonate and the greater therefore will be the efficiency of the explosive, though once detonation is effectively set up it will be independent of the strength of detonator used. The use of an inefficient detonator may result in portions of cartridges remaining undetonated and becoming a source of danger during the subsequent handling of the material that has been blasted. With the desensitized explosives that are used in coal mines the efficiency of the detonator may influence the safety of the explosive from the point of view of its ability to ignite firedamp. The present investigation has been carried out for that reason.
Time slot allocation scheme based on a region division in CDMA/TDD systems (2002)

In wireless multimedia networks, there exists traffic asymmetry between uplink and downlink channels. The CDMA/TDD system can alleviate this problem, however, previous work in this area can not manage efficiently the traffic, asymmetry among cells. In this paper, we propose a new time slot allocation scheme that considers the traffic pattern of each cell. To solve the inter-cell interference problem, we divide a cell's area into two regions and we allocate the resource of crossed slots to mobile stations which are existing in the inner-region. This proposed scheme increases the resource utilization and decreases the blocking probability of the system as a whole. And our DARD (Different time slot Allocation based on a Region Division) scheme outperforms conventional SA (Same time slot Allocation) scheme in the heterogeneous traffic environment.
Boris Eikhenbaum: Voices of a Russian Formalist (1997)

Introduction 1. A grandson makes his way 2. Demythologizing Tolstoy 3. Guarding the work-centred poetics 4. The formalist in crisis 5. Remythologizing Tolstoy 6. Restoring a voice 7. Losing a voice 8. Reading the legacy whole Notes Index.
Preventing severe respiratory syncytial virus disease: passive, active immunisation and new antivirals (2014)

In most high-income countries palivizumab prophylaxis is considered safe, efficacious and cost-effective for preventing respiratory syncytial virus (RSV) hospital admissions among specific subgroups of infants born preterm, with chronic lung disease or with congenital heart disease. Virtually all babies acquire RSV during infancy and previously healthy babies are not eligible to receive palivizumab. Emerging evidence suggests some benefit of palivizumab use in reducing recurrent wheeze among infants born preterm. Better longitudinal studies are needed to examine its clinical and cost-effectiveness on recurrent and chronic respiratory illness and associated healthcare burden on resources in the community and hospitals. Since 99% of child deaths attributed to RSV occur in resource poor countries where expensive prophylaxis is not available or affordable, palivizumab has limited potential to impact on the current global burden of RSV lower respiratory tract infection (LRTI). A range of candidate vaccines for active immunisation against RSV are now in clinical trials. Two promising new antivirals are also currently in phase I/II trials to test their effectiveness in preventing severe RSV LRTI. These agents may be effective in preventing severe disease and phase III studies are in development. In the absence of effective active immunisation against RSV infection, population level approaches to prevent severe RSV LRTI should continue to focus on reducing prenatal and environmental risk factors including prematurity, smoking and improving hygiene practices.
Review: <i>The Baldwin Locomotive Works, 1831-1915: A Study in American Industrial Practice</i>, by John K. Brown (1997)

Book Review| January 01 1997 Review: The Baldwin Locomotive Works, 1831-1915: A Study in American Industrial Practice, by John K. Brown The Baldwin Locomotive Works, 1831-1915: A Study in American Industrial PracticeJohn K. Brown Paul Israel Paul Israel Search for other works by this author on: This Site PubMed Google Scholar The Public Historian (1997) 19 (1): 115–116. https://doi.org/10.2307/3378999 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Paul Israel; Review: The Baldwin Locomotive Works, 1831-1915: A Study in American Industrial Practice, by John K. Brown. The Public Historian 1 January 1997; 19 (1): 115–116. doi: https://doi.org/10.2307/3378999 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Public Historian Search This content is only available via PDF. Copyright 1997 Regents of the University of California and the National Council on Public History Article PDF first page preview Close Modal You do not currently have access to this content.
On modeling and analyzing cache hierarchies using CASPER (2004)

The efficient use of cache hierarchies is crucial to the performance of uni-processor (desktop) and multiprocessor (enterprise) platforms. A plethora of research exists on the various structures and protocols that are of interest when considering caches. To enable the performance analysis of various cache hierarchies and associated allocation/coherence protocols, we developed a trace-driven simulation framework called CASPER - cache architecture simulation & performance exploration using refstreams. The CASPER simulation framework provides a rich set of features to model various cache organization alternatives, coherence protocols & optimizations, allocation/replacement policies, prefetching and partitioning techniques. In this paper, we describe the methodology behind CASPER, its detailed design and currently supported set of functionalities. CASPER has been used extensively for various research studies; a brief overview of some of these CASPER-based evaluation studies and their salient results will also be discussed. Based on its wide-ranging applicability, we believe CASPER is a useful addition to the performance analysis community for evaluating cache structures and hierarchies of various kinds.
Nonlocal Continuum Theory for Dislocation and Fracture. (1984)

By means of linear theory of nonlocal elasticity, solutions are given for some Voltera dislocations situated in an elastic solid. The stress fields are determined for screw and edge dislocations. The stresses and elastic energy are devoid of usual singularities predicted by the classical (local) elasticity. A theory is developed for continuous distributions of dislocations on the basis of nonlocal incompatible elasticity. Stress fields are given for volume, surface and line distributions of dislocations. Celebrated Peach-Koehler formula is modified to include nonlocal Green's functions. The stress fields for three- and two-dimensional cases and for the anti-plane strain are determined for line distributions. Calculations are carried out for the uniform distributions of edge and crew dislocations along a straight line segment. By means of the maximum stress hypothesis, a fracture criteria is introduced. Calculated theoretical strengths are in good agreement with those based on the atomic models. Reduction of material strength with the presence of dislocation line and the maximum number of dislocations are given. (Author)