gebhart/patrepeval huggingface dataset:
Laser ablation—laser induced breakdown spectroscopy (LA-LIBS): A means for overcoming matrix effects leading to improved analyte response (2009)

Laser-ablation laser-induced breakdown spectroscopy (LA-LIBS) is proposed as a novel analytical scheme with goals of improved analyte response, minimization of sample matrix effects, and use of non-matrix matched standards. A direct comparison of the LA-LIBS approach and a traditional direct LIBS analysis was made for a set of seven reference materials, ranging from nearly pure iron to copper-nickel and aluminum alloys. The precision of each approach was assessed using calibration curves, and the LA-LIBS configuration was demonstrated to consistently produce a superior analytical response, as assessed by the linear least-squares fit correlation coefficient and y-intercept values. Significantly, the normalized (by Fe) response of the four targeted analyte species (Al, Mn, Mg and Cu) was successfully reduced to a single calibration curve with the LA-LIBS approach. In addition, particle size measurements of the laser-ablation plume were recorded along with SEM and white-light interferometry analysis of ablation craters for assessment of the analytical sample as presented to the analytical LIBS plasma. Finally, the effect of carrier gas is explored by substitution of nitrogen with helium.
CRISPR-Cas in <i>Streptococcus pyogenes</i> (2019)

The discovery and characterization of the prokaryotic CRISPR-Cas immune system has led to a revolution in genome editing and engineering technologies. Despite the fact that most applications emerged after the discovery of the type II-A CRISPR-Cas9 system of Streptococcus pyogenes, its biological importance in this organism has received little attention. Here, we provide a comprehensive overview of the current knowledge about CRISPR-Cas systems from S. pyogenes. We discuss how the interplay between CRISPR-mediated immunity and horizontal gene transfer might have modeled the evolution of this pathogen. We review the current literature about the CRISPR-Cas systems present in S. pyogenes (types I-C and II-A), and describe their distinctive biochemical and functional features. Finally, we summarize the main biotechnological applications that have arisen from the discovery of the CRISPR-Cas9 system in S. pyogenes.
A New Access to 1-Naphthylamines by an Equivalent Semmler-Wolff Reaction (1993)

A new access to 1-naphthylamines from the corresponding 3,4-di-hydro-1(2H)-naphthalenones (α-tetralones) is described. It proceeds in a two-step sequence: preparation of the benzyl Schiff's base of an α-tetralone followed by aromatization over palladium catalyst, which happened to hydrogenolyze the benzyl group at the same time. Five 1-naphthylamines were prepared using this alternative path to the Semmler-Wolff reaction.
Property management as property rights governance (2006)

Purpose - To re-examine the role of property management from an institutional economics perspective. Design/methodology/approach - The role of property management is explored by asking why property management has emerged from the first principle. Then, an analytical framework for property management is put forward. Different dimensions of institutional arrangements, ranging from open access to communal private property or solely owned private property, are discussed in the real estate property context. Findings - The paper shows that a unique feature of property management is its role in excluding outsiders and resolving internal conflicts among the stakeholders of communal private property. Research implications/limitations - This approach opens up a new research agenda for property management. The adoption of different institutional arrangements in property management can be explained by further studies. Practical implications - The efficiency of different institutional arrangements for the governance of communal private property is situation-specific. An endogenous assumption of institutional regime property management practice greatly expands the flexibility of management. Originality/value - This paper is the first to apply an analytical framework for interpreting the institutional arrangements in property management. © Emerald Group Publishing Limited.
Stem Cell Transplantation in Inherited Metabolic Disorders (2011)

Allogeneic HSCT is performed for a small number of inborn errors of metabolism (IEM). Over the last years, transplantation outcomes have improved in this group of patients as the factors that predicted for poor transplantation outcomes were understood and addressed. The role of transplantation and its potential benefit for an individual patient with a certain IEM is therefore now much better defined. In parallel with improvements in transplantation techniques, other therapies such as pharmacological enzyme replacement therapy (ERT), substrate inhibition, and gene therapy have been developed and are increasingly available to clinicians and their patients. This review covers the following areas: (1) the scientific principles that underpin transplantation in IEM; (2) the variables of the transplantation process itself that predict for successful outcome in terms of engrafted survival after HSCT; (3) the reasons that some apparently phenotypically similar disorders might respond very differently to transplantation therapy; (4) the factors that currently influence the response of a particular patient with a particular disease to allogeneic transplantation, and how these factors might be manipulated in the future to further improve transplantation outcomes in different metabolic illnesses; and (5) how other therapeutic modalities, including ERT, gene therapy, and substrate reduction therapy, might complement and compete with HSCT in the coming years.
Isolation of multidrug resistance associated protein like gene from lead hyperaccumulator common buckwheat and its lead detoxification ability (2010)

A multidrug resistance associated protein homolog gene, named FeABCC1, was isolated from a commercial brand of common buckwheat that has high lead tolerance and accumulation ability. The deduced amino acid sequence of FeABCC1 had 64% identity with AtMRP3 (AtABCC3) of Arabidopsis thaliana, and was predicted as integral membrane protein with 12 transmembrane domains. FeABCC1 expression was induced in the shoot of common buckwheat treated with lead. The yeast transformed with FeABCC1 showed a marked increasing in lead tolerance with the gene expression, and accumulated more lead compared to control. Not similar to AtMRP3, FeABCC1 expression did not effect to cadmium tolerance in yeast, and inhibition of glutathione synthesis by buthionine sulfoximine was not effect lead tolerance. These data suggests that FeABCC1 has some role for lead detoxyfication in common buckwheat independently to glutathione chelating.
A new method for detecting abrupt shifts in time series (2019)

<ns4:p> Abrupt shifts in time series are a topic of growing interest in a number of research areas. They can be caused by a range of different underlying dynamics, for example, via a mathematical bifurcation, or potentially as the result of an auto-correlated stochastic process (i.e. ‘red’ noise). Here we present a method that detects abrupt shifts by searching for gradient changes that occur over a short space of time. It can be automated, allowing many time series to be analysed by the user at once, such as from high spatial resolution data. Our method detects abrupt shifts regardless of their origin (which it cannot deduce). We present a comparison with the method of abrupt shift detection from the <ns4:ext-link xmlns:ns3="http://www.w3.org/1999/xlink" ext-link-type="uri" ns3:href="https://cran.r-project.org/web/packages/changepoint.mv/index.html">changepoint</ns4:ext-link> R package, which is based on changes in mean over the time series. Our method performs better on data with an underlying trend where comparisons of means may fail. </ns4:p>
Synthesis, structure, and spectroscopic properties of an unusual copper(I) dimer having imidazole ligands. A model for the carbonyl derivative of hemocyanin and implications for the structure of deoxyhemocyanin (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, structure, and spectroscopic properties of an unusual copper(I) dimer having imidazole ligands. A model for the carbonyl derivative of hemocyanin and implications for the structure of deoxyhemocyaninThomas N. Sorrell and A. S. BorovikCite this: J. Am. Chem. Soc. 1987, 109, 14, 4255–4260Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://doi.org/10.1021/ja00248a020RIGHTS & PERMISSIONSArticle Views436Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (767 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Data mining for telecommunications network log analysis (2009)

Telecommunications network management is based on huge amounts of data that are continuously collected from elements and devices from all around the network. The data is monitored and analysed to provide information for decision making in all operation functions. Knowledge discovery and data mining methods can support fast-pace decision making in network operations. \n\nIn this thesis, I analyse decision making on different levels of network operations. I identify the requirements decision-making sets for knowledge discovery and data mining tools and methods, and I study resources that are available to them. I then propose two methods for augmenting and applying frequent sets to support everyday decision making. The proposed methods are Comprehensive Log Compression for log data summarisation and Queryable Log Compression for semantic compression of log data. Finally I suggest a model for a continuous knowledge discovery process and outline how it can be implemented and integrated to the existing network operations infrastructure.
Plagiarism detection in software designs (2004)

Detecting plagiarism in software is a computationally complex process. At the same time it is critical, for the lack of a deterrent through detection may result in various losses. Several systems to detect plagiarism have been proposed. However, their lexically-based analysis is not powerfull enough and can be foiled with minimal efforts. To address their shortcomings, we have devised a detection framework with the following salient features: (1) designs, instead of code, are compared; (2) multi--level abstractions of the design are generated; and (3) comparison follows a stepwise process according to the abstraction levels. A comparison with existing systems shows that this strategy results in simpler algorithms and more accurate analyses.
Microbial reduction of 1,2-diketones to optically active .ALPHA.-hydroxyketones. (1987)

The microorganisms that reduce benzil to optically active benzoin were screened. Xanthomonas oryzae IAM 1657 was selected as the best strain, which resulted in the formation of (R)-(-)-benzoin. This biochemical reduction was applied to other 1, 2- and 1, 3-diketones to find that only 1, 2-diarylethanediones were reduced smoothly to afford the corresponding ketols.
Genetic-Background Modulation of Core and Variable Autistic-Like Symptoms in Fmr1 Knock-Out Mice (2011)

The Fmr1-mouse line does not recapitulate all of the main core and secondary ASD symptoms, but still can be useful to elucidate the neurobiological mechanisms underlying specific ASD-like endophenotypes.
Learning Multi-View Representation With LSTM for 3-D Shape Recognition and Retrieval (2018)

Shape representation for 3-D models is an important topic in computer vision, multimedia analysis, and computer graphics. Recent multiview-based methods demonstrate promising performance for 3-D shape recognition and retrieval. However, most multiview-based methods ignore the correlations of multiple views or suffer from high computional cost. In this paper, we propose a novel multiview-based network architecture for 3-D shape recognition and retrieval. Our network combines convolutional neural networks (CNNs) with long short-term memory (LSTM) to exploit the correlative information from multiple views. Well-pretrained CNNs with residual connections are first used to extract a low-level feature of each view image rendered from a 3-D shape. Then, a LSTM and a sequence voting layer are employed to aggregate these features into a shape descriptor. The highway network and a three-step training strategy are also adopted to boost the optimization of the deep network. Experimental results on two public datasets demonstrate that the proposed method achieves promising performance for 3-D shape recognition and the state-of-the-art performance for the 3-D shape retrieval.
Fully integrated wideband high-current rectifiers for inductively powered devices (2004)

This paper describes the design and implementation of fully integrated rectifiers in BiCMOS and standard CMOS technologies for rectifying an externally generated RF carrier signal in inductively powered wireless devices, such as biomedical implants, radio-frequency identification (RFID) tags, and smartcards to generate an on-chip dc supply. Various full-wave rectifier topologies and low-power circuit design techniques are employed to decrease substrate leakage current and parasitic components, reduce the possibility of latch-up, and improve power transmission efficiency and high-frequency performance of the rectifier block. These circuits are used in wireless neural stimulating microsystems, fabricated in two processes: the University of Michigan's 3-/spl mu/m 1M/2P N-epi BiCMOS, and the AMI 1.5-/spl mu/m 2M/2P N-well standard CMOS. The rectifier areas are 0.12-0.48 mm/sup 2/ in the above processes and they are capable of delivering >25mW from a receiver coil to the implant circuitry. The performance of these integrated rectifiers has been tested and compared, using carrier signals in 0.1-10-MHz range.
CLF/Mekano: a framework for building virtual-enterprise applications (1999)

CLF/Mekano is a distributed object infrastructure oriented towards the high-level coordination of coarse grain components. Unlike other infrastructures of the same class, such as CORBA or DCOM, coordination in CLF/Mekano is built-in at the lowest level, namely at the inter-component communication protocol level, and not as a side service (such as the event, transaction or negotiation services of Corba). Although the CLF protocol is "lightweight" (it relies on very few concepts and only 8 communication "verbs"), it makes the design and implementation of components more complex, but also more valuable if it can be reused. The Mekano library has been developed in order to deal with this complexity, targeting reusability. It provides ready-to-use generic classes of customizable components, as well as useful component parts which can be reassembled according to application specific needs. Of course, further layers of domain-specific libraries (so called business object libraries), can then be developed on top of Mekano, to provide ready-to-use components dedicated to specific business needs (in the line of Enterprise Java Beans).
Clinical evaluation of cryoprecipitated factor 8 (1967)

Although there is increasing reason to believe that the pathogenesis of classical hemophilia involves much more than deficiency of a plasma clotting factor,<sup>1</sup>treatment of bleeding episodes remains firmly based upon the infusion of factor VIII.<sup>2</sup>The rationale of plasma transfusion therapy has been well defined<sup>3</sup>and assay procedures<sup>4,5</sup>have been developed which permit an accurate diagnosis of hemophilia (hemophilia A), and, in addition, enable quantitative assessment of therapy. Nevertheless, treatment of this disorder still is beset with difficulties. Large and frequent transfusions of fresh, freshfrozen, or reconstituted freeze-dried plasma are required to achieve and maintain hemostatic levels of factor VIII. Daily transfusions approximating one third of the patient's circulating plasma volume are required over a period of weeks to control hemorrhage following surgical procedures. Such massive plasma transfusions present the concomitant risk of circulatory overload. Moreover, prolonged plasma therapy limits the mobility of the patient
Educational Participation and Dietary Changes of EFNEP Homemakers in Louisiana<sup>1</sup> (1973)

Are dietary levels of homemakers participating in a nutrition educational program influenced by length of participation? By the kind of learning experience they are involved in? By the intensity of the learning exposure? These questions were examined in the Expanded Food and Nutrition Education Program (EFNEP) in Louisiana to see how diets changed over a 12‐month period. Homemakers were instructed through personal visits and meetings. Consumption of the basic four food groups was found to increase in the first 2 to 4 months, then reach a plateau. Other studies in Louisiana indicated a drop, either to former or slightly higher than former levels, when the educational effort was discontinued. Visits and meetings had about the same effect on diet changes, but more people were reached through meetings. Intake of two food groups correlated positively with frequency of visits or meetings. The findings suggested the need for a continuing education program using a variety of teaching procedures, combined with better tools for evaluating effectiveness of the educational effort.
Effects of transforming growth factor <i>beta</i> on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness. (1986)

Type beta transforming growth factor (TGF-beta) is a unique polypeptide that has been isolated from a number of different tissues and can induce the phenotypic transformation of non-neoplastic fibroblasts as measured by the stimulation of their growth in soft agar. Recently, TGF-beta has been demonstrated to exert profound inhibitory effects on T and B lymphocyte proliferation. In this study, the effects of TGF-beta on natural killer (NK) cell function were investigated. After 20 hr of culture in the presence of TGF-beta, the NK activity of peripheral blood lymphocytes (PBL) was significantly reduced compared with PBL cultured in medium alone. Similarly, TGF-beta produced a significant depression in the cytolytic activity of highly enriched large granular lymphocytes (LGL). This effect of TGF-beta appeared to be mediated directly on the effector cells, because cultivation of the K562 target cells in TGF-beta did not affect target cell susceptibility to lysis. Binding studies with 125I-TGF-beta indicated that LGL possess approximately 1400 high-affinity (Kd = 1PM) receptors/cell, which represents a considerably higher affinity receptor for TGF-beta than that found on fibroblasts. Culturing of PBL and LGL in TGF-beta resulted in a marked blunting of the boosting of NK cytolysis by interferon-alpha but not by interleukin 2, which suggested that TGF-beta may down-regulate interferon-alpha receptors on NK cells. These results, indicate that in addition to inhibitory effects on T and B cells, TGF-beta also inhibits NK cell function. Although the in vivo role of TGF-beta is presently undefined, it may be an important immunoregulatory protein that has a negative influence on lymphocyte activation.
Binding of hyaluronan to lysozyme at various pHs and salt concentrations. (1991)

Binding of hyaluronan (HA) to lysozyme immobilized on Sepharose-6B was investigated as a function of pH and NaCl concentration. High affinity binding (Kd = 1.0-2.0 x 10(-8) M) was observed at pH 7.5 and at 10-50 mM NaCl; the number of moles of HA bound to lysozyme was twice as high at 30 mM NaCl as at 10 mM. No specific binding was observed at and above 100 mM NaCl. Binding was suppressed in the presence of chaotropic agents such as guanidinium chloride and urea. These results suggest that binding between HA and lysozyme can occur in the extracellular matrix where an electrolyte concentration as low as 50 mM could be expected due to ionic exclusion by the highly negative charge concentration arising from the polyanions present.
Neural network based video surveillance system (2005)

Video surveillance systems are usually composed of a network of active video sensors that continuously capture the scenes and present them to a human operator for analysis and event detection. Unfortunately human operators are often unable to monitor the video streams coming from a large number of video sensors. In this paper a semantic event detection system based on a neural classifier is presented to screen continuous video streams and detect relevant events, specifically for video surveillance. The goal of the proposed system is to automatically collect real-time information to improve the awareness of security personnel and decision makers. Our research is focused on the use of the "known scene rarr no alarm/unknown scene rarr alarm" paradigm, where the meaning of scene is related to spatial-temporal events, instead of the classical "frame difference" paradigm. The proposed system is able to detect mobile objects in the scene and to classify their movements (as allowed or disallowed) so as to raise an alarm whenever unacceptable movements are detected. This ability is supported also for video cameras mounted on a motorized pan scanner: experiments showed that the system is able to compensate the background changes due to the camera motion
Islet xenotransplantation: current status of preclinical studies in the pig-to-nonhuman primate model (2008)

Of the possible organ candidates for xenotransplantation, porcine islets are the closest to a possible clinical application. Prior to the initiation of ethical and safe clinical trials, however, further efforts to generate additional efficacy and safety data in the nonhuman primate model will be indispensable.
Cannabidivarin‐rich cannabis extracts are anticonvulsant in mouse and rat via a <scp>CB<sub>1</sub></scp> receptor‐independent mechanism (2013)

CBDV BDSs exerted significant anticonvulsant effects in three models of seizure that were not mediated by the CB1 cannabinoid receptor and were of comparable efficacy with purified CBDV. These findings strongly support the further clinical development of CBDV BDSs for the treatment of epilepsy.