gebhart/patrepeval huggingface dataset:
Inhibition of apoptosis in colon tumors induced in the rat by 2-amino-3-methylimidazo[4,5-f]quinoline. (1996)

The cooked meat mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) produces tumors at multiple sites in the F344 rat, including adenocarcinomas of the colon. In the present study, the development of IQ-induced colorectal tumors was shown to be accompanied by the progressive inhibition of programmed cell death. This was associated with increased expression of the antiapoptosis protein Bcl-2 and decreased expression of bax, a known activator of apoptosis. Carcinomas bearing high levels of bcl-2 expression exhibited low levels of p53, the tumor suppressor protein that in some circumstances has been shown to down-regulate bcl-2. Because they lack mutations in the genes commonly associated with increased cell proliferation (APC, Ki-ras, and p53) and show no evidence of microsatellite instability, IQ-induced colon tumors might arise via the deregulation of bcl-2 expression, leading to inhibition of programmed cell death.
A Low-Complexity Scheduling for Joint Unicast and Multicast Transmissions in LTE-A Network (2018)

LTE broadcast is an emerging 4G technology that allows the transmission of the same content, typically MBMS streams, to multiple users located in one or many cells belonging to a common area called Multicast Broadcast Single-Frequency Network (MBSFN) area. This promising transmission technique allows significant bandwidth saving but faces many challenges in the joint management of unicast and multicast/broadcast transmissions, especially with the evolved MBMS (eMBMS) that allows unicast reception in the MBSFN subframes. In a recent work, an algorithm based on finding the best multicast users' grouping with respect to their channel conditions, and making resource allocations for unicast users and multicast subgroups according to a predefined fairness function has efficiently solved the problem. However, the allocation for both unicast and multicast connections was made in terms of resource blocks (RB), which does not comply with 3GPP standards. In this paper, we propose a compliant standard version of this algorithm, which considers subframes as a scheduling granularity. Our proposition significantly reduces the computation complexity from O(M <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> ) to O(M) and overcomes the drawbacks of the initial algorithm, which is clearly shown in the numerical results of our enhanced version, especially in terms of time complexity and total data rate received by all users, while keeping a comparable performance in terms of system utility.
Can precursors improve the transmission of energy at optical frequencies? (2009)

The recent interest in precursors has been fuelled by the possibility of using them for the efficient transmission of information through absorbing media at radio or optical frequencies. Here we demonstrate that the low attenuation experienced by the Brillouin precursor is attributed to the inherently low absorption of dispersive media near DC, a characteristic already exploited with communications systems using the extremely low frequency (ELF) band. Pulses, regardless of their temporal width and carrier frequency, always obey Beer's law as long as they propagate in the linear time invariant regime. We conclude with an FDTD simulation of the Maxwell-Bloch equations that shows how optical coherent bleaching effects, which take place in the linear time variant regime of the Lorentz oscillator model, can cause sustained deviations from Beer's law over relatively long distances of water.
The Cell Cycle: Principles of Control (2006)

The Cell Cycle: Principles of Control provides an engaging insight into the process of cell division, bringing to the student a much-needed synthesis of a subject entering a period of unprecedented growth as an understanding of the molecular mechanisms underlying cell division are revealed.
[Isolation of staphylococcal enterotoxin type B and a study of its physicochemical, biological and immunological properties]. (1983)

The homogeneous preparation of type B staphylococcal enterotoxin (SEB) has been obtained by its adsorption from the culture fluid on amberlite, elution, isoelectric focusing in the ampholine system and gel filtration in a column packed with Sephadex G-25. The isolated SEB component is a thermostable protein, homogeneous in its antigenic composition and according to the results of disc electrophoresis in acrylamide gel. Its molecular weight is 28,000 daltons with pI equal to 8.6 (the main component), 8.0 and 8.25 (the minor components). All the forms are immunochemically identical. The minimum enterotoxic dose of SEB for cats is 3-5 micrograms per kg of body weight. The biological activity of the enterotoxin disappears under the action of 6 M urine. Monospecific antiserum to SEB with a precipitating antibody titer of 1:64 has been obtained.
Polypeptide nanocoatings for preventing dental and orthopaedic device‐associated infection: pH‐induced antibiotic capture, release, and antibiotic efficacy (2007)

Implant-associated infection is one of the most common and problematic complications for dental and orthopaedic patients. Modification of currently used implant surfaces aimed at bestowing them with antibacterial properties is a promising approach in the development of new biomaterials. In this study, a novel nanotechnology, that is, electrostatic self-assembly, was developed to construct biomimetic polypeptide nanocoatings on commonly used metal implants. A model antibacterial drug, cefazolin, was captured in the polypeptide nanocoating and its release was studied. We have shown that the capture and release of cefazolin was pH-induced and could be controlled, and the developed antibiotic-incorporated polypeptide multilayer nanocoatings could prevent Staphylococcus aureus colonization thus showing great potential for preventing implant-associated infection.
The Poincaré half-plane : a gateway to modern geometry (1993)

In the 1880s, over fifty years after the discovery of the hyperbolic plane, Poincare pointed out that this plane provides a very useful context for describing the properties of the solutions of an important class of differential equations. Topics include Euclidean rigid motions, inversions, Euclidea
Matrix-based Change Impact Analysis for Component-based Software (2007)

Component-based software (CBS) is built through the ways of composition and integration, this development style is quite favorable for modification or upgrade of system. However, making sure that the modified system still works is a challenge. In order to facilitate the maintenance activities and their optimum configuration, it is necessary to measure the changes. This paper mainly discusses the case of component modification, including the single component change and the changes of multi-components, and presents the algorithms for measuring the change impacts in CBS for each situation. Finally, the on-going research plan is addressed.
Studies on Menstrual Blood Loss in Intactand Experimental Rhesus Monkeys (1973)

An improved method of measuring menstrual blood loss (MBL) in rhesus monkeys is developed and appears to be accurate within ± 10% of actual loss. MBL and intraindividual variations of MBL are measured in three groups of captive rhesus monkeys: intact, with surgical uterocutaneous fistulas, and ovariectomized with fistulas. On a volume per body weight basis, MBL of healthy, non-anemic women compares favorably to that of healthy female rhesus monkeys. Using duration of menses as an index of MBL is found to be of little value in practical applications.
Dispersion and dispersion-slope correction with a fiber Bragg grating over the full C-band (2002)

Long-length wide-bandwidth fiber Bragg gratings for use as dispersion compensators that cover the full C-band have been fabricated. These devices are shown to work well in a 10 Gbit/s NRZ optical communications system.
Crosslinking of Soybean 7S and 11S Proteins by Transglutaminase (1980)

Journal Article Crosslinking of Soybean 7S and 11S Proteins by Transglutaminase Get access Koji Ikura, Koji Ikura Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Takashi Kometani, Takashi Kometani Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Ryuzo Sasaki, Ryuzo Sasaki Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideo Chiba Hideo Chiba Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 44, Issue 12, 1 December 1980, Pages 2979–2984, https://doi.org/10.1080/00021369.1980.10864428 Published: 01 December 1980 Article history Received: 08 August 1980 Published: 01 December 1980
Photodestruction of Propionibacterium acnes Porphyrins (1985)

The fluorescence spectra of colonies of Propionibacterium acnes were studied under various experimental conditions. The spectra contained peaks at 580 nm and 620 nm. These bands were due to two different components; the 580 nm component was likely to be a metalloporphyrin, and there are indications that the 620 nm component could be a coproporphyrin. The 580 nm fluorescence was destroyed by the combined action of light and oxygen (no destruction under strict anaerobic conditions). A dark period interrupting the bleaching light stopped the destruction of this component for the time of the dark period. The initial production of the 620 nm component was due to the oxygen exposure. Upon light irradiation this component was later destroyed by the combined action of oxygen and light.
Insulin-degrading enzyme. (1996)

The authors review recent research on an enzyme hypothesized to play a major role in the degradation of insulin. After binding to its receptor on the cell surface, insulin is internalized by receptor-mediated endocytosis and degraded within components of the endosomal apparatus. Degradation of insulin is important in the termination of signaling and clearance of the circulating hormone. It has been proposed that insulin-degrading enzyme (IDE), an evolutionarily conserved, neutral thiol-metalloendopeptidase, plays a crucial role in the degradation of internalized insulin in many types of cells. Despite the substantial evidence supporting the importance of IDE in cellular insulin degradation, there is controversy over its mode and site of action, mainly because of its cytosolic location. Its physiological location in cells has recently been elucidated through subcellular fractionation of liver parenchyma and through immunofluorescence microscopy of stably transfected Chinese hamster ovary cells that overexpress IDE. These experiments have excluded the presence of the enzyme in endosomes and have defined a peroxisomal location, consistent with the presence of a peroxisomal targeting sequence at the carboxyl terminus of the protein. Recently, researchers have demonstrated the functional significance of peroxisome-associated IDE (type I peroxisomal enzyme) in degrading cleaved leader peptides of peroxisomal proteins targeted by the type II motif. IDE is the first cloned and characterized proteinase to be localized to peroxisomes. Moreover, IDE appears to be a member of a newly identified superfamily of metalloendopeptidases that has an HXXEH active-site motif. Although fundamental questions concerning the biological role of IDE remain, its high degree of evolutionary conservation suggests that it must have important functions and multifaceted biological significance.
Computer-aided reverse engineering system in the design and production of orthotic insole shoes for patients with diabetes (2018)

Design and manufacturing strategies for custom orthotic insole shoes for patients with diabetes are presented in this paper. The computer-aided reverse engineering system (CARESystem) was applied for minimizing file errors generated by scanning a patient’s foot. The digital data imaging and communication of medicine (DICOM) images were used for designing complex insole orthotics. The DICOM images obtained by HandySCANN 700TM were then converted into a stereo lithography (STL) file (triangle-based data) format. The color map generated by VX Element and Geomagic software yielded an accurate and smooth STL data file of the patient’s foot. A solid 3D model of orthotic shoe s (insole and outsole) was prepared using the curve-based surface modeling method (CBS model). The error of an image found in the 3D mesh STL file was then edited and smoothed, prior to the 3D prototype products being processed by 3D printers. The prototype of an orthotic shoe insole was fabricated by an adaptive manufacturing machine, the 3D printer EDEN350. Comparative analysis of dimensional data for the insole and outsole revealed that the average size of deviation was less than 1 mm (0.0135–0.0209 mm). Therefore, this method is highly promising to deliver custom orthotics with improved size, dimensional accuracy, and comfort.
Electrostatic manipulation of DNA in microfabricated structures (1990)

Experimental observation of the electrostatic orientation and dielectrophoresis of DNA under a high-intensity field produced in a microfabricated electrode system is made, using the fluorescent method as a visualization technique. It is shown that the orientation takes place under a field strength of 10/sup 6/ V/m and the frequency at around 1 MHz. The stretch and shrink of an individual molecule is observed as the field is switched on and off. The molecular size (i.e. number of base pairs) is obtainable by measuring the stretched length of the molecule. A special field configuration is designed for the efficient molecular size determination using this principle. Molecular manipulation techniques, the alignment and positioning of the individual molecule, and the cutting of DNA at arbitrary locations with an ultraviolet beam are developed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Drug selection errors in relation to medication labels: a simulation study (2007)

The aim of this study was to assess the impact of differences in drug label information on injectable drug selection errors. Differences in the display of drug strength information were assessed in a randomised controlled trial involving ward nurses, intensive care nurses, nurse anaesthetists, ward physicians, and anaesthetists. A set of 24 on-screen tasks were constructed. For each task, a label corresponding to an instruction consisting of two from three possible pieces of information (concentration, quantity, volume) had to be selected from a list of 10 items. The set was presented three times to participants using three different label formats. Format A provided two pieces of strength information different from those in the instruction. Format B and C provided all three pieces in a random and a fixed sequence, respectively. The frequency of errors was statistically higher with formats A and B than with format C, and greater in nurses than in anaesthetists. Regulatory bodies should therefore implement a standard requiring that the concentration (expressed in 'mg x ml(-1)'), the amount and the volume of drug be displayed on medication labels in fixed locations.
The antileukemic activity of Δ12-PGJ3 (2011)

In this issue of Blood, Hegde et al show that a novel and naturally produced eicosapentaenoic acid-derived cyclopentenone prostaglandin has antileukemic activity. 1 12 -PGJ 3 -mediated apoptosis of leukemic stem cells is mediated at least in part by ATM-p53 signaling.
DNA Delivery to Cells In Vivo by Ultrasound (2004)

In vivo gene delivery has proven to be much more difficult than in vitro delivery. Many techniques have worked in vitro only to fail in vivo. Techniques such as electroporation require invasive and painful procedures to deliver genes. Ultrasound-mediated delivery has the potential to help overcome these difficult and painful aspects with a simple noninvasive procedure.
Serpentine geometry plasma actuators for flow control (2013)

In this paper, a curved class of plasma actuator geometries is presented. The intension of this paper is to extend the versatility of a dielectric barrier discharge plasma actuator by modifying the geometry of its electrodes, so that the plasma generated body force is able to excite a broader spectrum of flow physics than plasma actuators with a more standard geometry. Two examples of flow control are demonstrated numerically. An example of this class of actuators is shown to generate boundary layer streaks, which can be used to accelerate or delay the laminar to turbulent transition process, depending on how they are applied. Simulations of a low Reynolds number airfoil are also performed using additional examples of this class of actuators, where it is shown that this plasma actuator geometry is able to introduce energy into and excite a secondary instability mode and increase unsteady kinetic energy in the boundary layer. These two cases show that this general class of curved actuators possesses an increased versatility with respect to the standard geometry actuators.
Integration of Focus and Defocus Analysis with Color Stereo for Three-Dimensional Shape Recovery (1999)

Recovering the 3D (three-dimensional) shape of objects in a scene is an important topic in computer vision. Several methods including passive and active methods are developed to investigate this topic. Two kinds of information are recovered during the 3D shape recovery. One is the geometric information about the shape of the object. The other is the photometric information about the light energy distribution on the object surface. One effective method is developed in this research and its algorithms and results are presented in this dissertation. The method developed in this research integrates three important techniques in machine vision IFA (Image Focus Analysis), IDA (Image Defocus Analysis), and SIA iv (Stereo Image Analysis). IDA is used to fast d...
Electroluminescence from Metal‐Containing Polymers and Metal Complexes with Functional Ligands (2007)

This chapter contains sections titled: Introduction Traditional Materials Used in OLEDs Molecular Materials Polymeric Materials Development of Phosphorescent Materials for OLEDS Small Molecules – Pure Organic Dyes and Organometallic Complexes Polymeric Materials Ruthenium Containing Polymers Photophysics of Ruthenium Complexes Examples of Ruthenium Complex Containing Polymers Ruthenium Complexes for Light-Emitting Devices Complexes Based on Multifunctional Ligands Ruthenium Containing Polymers for Light-Emitting Devices EL Devices Based on Ruthenium Complex Containing Nonconjugated Polymers Multifunctional Ruthenium Complex Containing Conjugated Polymers Conjugated Polymers with Pendant Metal Complexes Summary
Time management in the DoD high level architecture (1996)

Recently, a considerable amount of effort in the U.S. Department of Defense has been devoted to defining the High Level Architecture (HLA) for distributed simulations. This paper describes the time management component of the HLA that defines the means by which individual simulations (called federates) advance through time. Time management includes synchronization mechanisms to ensure event ordering when this is needed. The principal challenge of the time management structure is to support interoperability among federates using different local time management mechanisms such as that used in DIS, conservative and optimistic mechanisms developed in the parallel simulation community, and real-time hardware-in-the-loop simulations.
The influence of Ag+, Zn2+ and Cu2+ exchanged zeolite on antimicrobial and long term in vitro stability of medical grade polyether polyurethane (2011)

This study aims to investigate the limitations and applicability of different ion exchanged zeolites as antimicrobial additive in thermoplastic polyether type polyurethanes. These composites were designed to improve the health quality of hospitalized patients by expressing both biocompatibility and relevant antimicrobial activity. The zeolites were exchanged with silver, copper and zinc ions and single, binary and ternary ion-exchanged zeolite-polyurethane composites were prepared. The antimicrobial activity and the resistance of the composites against the human environment play vital role in the applicability of the materials as a medical device therefore these properties were investigated. The antimicrobial test were performed on Methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Candida tropicalis. The tests showed that the efficiency of the silver ions is superior to the other single ionic systems. Besides, the binary and ternary ion-exchanged samples had similar antimicrobial efficiency regardless the type of the ions in the zeolite. The biocompatibility tests were carried out in-vitro in artificial body fluids for a period of 12 weeks. As a result of the invitro test, degradation of the composites were observed and the structural changes of the materials were detected and described by Scanning Electron Microscopy, Contact Angle measurements and Attenuated Total Reflection Fourier Transform Infrared Spectroscopy.
Primary photochemical processes in aromatic molecules. Part 15.—The photochemistry of aromatic carbonyl compounds in aqueous solution (1972)

Phosphorescence has been observed from oxygen-free aqueous solutions of benzophenone and acetophenone. In the case of benzophenone the phosphorescence is strongly self-quenched. Rate constants for quenching of triplet benzophenone by various species have been measured.The photoreactivity of benzophenone in water has been reinvestigated. Photolysis does occur, the quantum yield being low and somewhat irreproducible. Benzopinacol is a product of the photolysis in oxygen-free solution, while in aerated solution hydroxybenzophenones are formed with a very low quantum yield.Flash photolysis experiments have characterized the triplet-triplet absorption of benzophenone in aqueous solution and show that the ketyl radical and another radical are intermediates in the reaction. It is suggested that hydrogen abstraction from water occurs to give free OH radicals which then attack benzophenone to give a cyclohexadienyl radical. The energetics of this process are considered.
Mathematical machining model and simulation of limacon gear set (2010)

Limacon gear is a new kind of non-circular gear, and its gear set have precise transmission ratio. The principle of generating method is that tooth profile of the conjugated gears can form envelope graph to each other. Aimed at the processing problem of limacon gear set with involute tooth profile, the tooth profile equation of the gear shaping cutter was established. The position relationship between the cutter's and the gear's pitch curve was analyzed, and a simpler machining mathematical model was put forward. The gear set machined with this model have been put into practice, and have gained favorable effect. So this model is important to designing and manufacturing limacon gear set both in theory and in practice.