gebhart/patrepeval huggingface dataset:
Optimal light dose for interstitial photodynamic therapy in treatment for malignant brain tumors (2000)

Background and Objective The primary goal was to determine the maximal tolerable light dose that can be administered to patients undergoing multifiber interstitial photodynamic therapy (PDT) of malignant brain tumors at a fixed dose of photosensitizer. Study Design/Materials and Methods Eighteen patients (12 glioblastomas, 5 anaplastic astrocytoma, and 1 malignant ependymoma) were included in this study. The total light dose delivered to the tumor was divided into three groups of six patients each: 1,500–3,700 J, 3,700–4,400 J, and 4,400–5,900 J. Results Five patients (all glioblastomas) demonstrated postoperative permanent neurologic deficits. None of the patients in 1,500–3,700 J, two patients in 3,700–4,400 J, and three patients in 4,400–5,900 J had neurologic deficits. Glioblastomas recurred more often than anaplastic astrocytomas. Increasing the light dose did not make a difference in local/regional control of glioblastomas. Patients with anaplastic astrocytomas survived (mean, 493 days) longer than patients with glioblastomas (mean, 116.5 days) after PDT. Four patients had prolonged survival (more than a year) after PDT. Conclusions Increasing the total light dose delivered to the tumor increases the odds of having a permanent neurologic deficit but does not increase survival or time to tumor progression. There was no difference in local or marginal recurrence with increasing light dose. Recurrent anaplastic astrocytomas tend to do better than recurrent glioblastomas with PDT. Lasers Surg. Med. 27:224–234, 2000. © 2000 Wiley-Liss, Inc.
Pulsed-field fingerprinting of listeriae: identification of genomic divisions for Listeria monocytogenes and their correlation with serovar (1994)

Clamped homogeneous electric field (CHEF) electrophoresis was optimized for genomic analyses of Listeria monocytogenes. Various human, animal, food, and environmental isolates, as well as strains representing other Listeria species, were separately digested with rarely cutting endonucleases. Of 176 L. monocytogenes strains analyzed, the enzymes AscI and ApaI established 63 and 72 unique restriction endonuclease digestion profiles (REDP), respectively. The 22 non-L. monocytogenes strains exhibited 18 AscI and 19 ApaI unique REDP. Statistical analyses of REDP information using the Dice coincidence index and principal component analysis revealed two distinct genomic divisions of L. monocytogenes that also correlated with the flagellar (H) antigen type: division I contained serovar 1/2a, 1/2c, 3a, and 3c stains and division II contained serovar 1/2b, 3b, 4b, 4d, and 4e strains. Division I isolates digested with ApaI were further grouped into cluster IA (serovar 1/2c and 3c) and cluster IB (serovar 1/2a and 3a) strains. Likewise, division II isolates digested with ApaI were further grouped into cluster IIA (serovar 1/2b and 3b) and cluster IIB (serovar 4b, 4d, and 4e) strains. These data indicate that genotypic data generated by CHEF can be directly related to phenotypic data generated by serotyping for establishing the overall relatedness of isolates. Moreover, these data further substantiate that CHEF analysis is a reproducible and highly discriminating method for characterizing L. monocytogenes strains at the molecular level.
A visualization tool for analyzing cluster performance data (2001)

This paper describes a unique visualization tool that has been used to analyze performance of the Cplant(tm) clusters at Sandia National Laboratories.As commodity cluster systems grow in size and complexity, understanding performance issues becomes more and more difficult.We have developed a tool that facilitates visual performance analysis within the context of the physical and runtime environment of a system. Combining an abstract system model with color-coding for both performance and job information enables quick fault isolation as well as insight into complex system behavior.
Impact of age on QT interval and QT dispersion in healthy subjects: a regression analysis (2003)

after adjusting for gender, smoking status, and blood pressure, age and body mass index independently predicted QT interval in healthy subjects. By contrast, age is not a predictor of QTd. The increase of QT interval associated with ageing and body mass index might be secondary to cardiac hypertrophy and myocardial action potential prolongation.
Antibacterial properties of some metals and alloys in combating coliforms in contaminated water (2010)

An investigation into the antibacterial properties of silver, copper, aluminium, zinc, brass, bronze, tin and silicon, in combating coliform bacteria in contaminated water has been carried out. The metals, in the form of thin plates, were immersed in water samples at various time intervals at room temperature (~20°C). Total coliform and Escherichia coli (E. coli) enumeration was done on the samples, before and after immersion, using 3 M Petri films. The results show that copper, silver and zinc in group I and II of the periodic table of elements have the highest rate of destroying the bacteria, followed by aluminium in group III, and the least reaction was in tin and silicon, both in group IV. These results indicate that the antibacterial activity of materials depend on the group they belong to in the periodic table; the higher the group the lower their efficacy. No direct relationship has been found between the metal activity and ionisation energy.  An interesting observation was that zinc was as effective as copper in destroying the bacteria.  It was also found that the more the surface area of the metals, the faster they destroyed the coliforms. Practical applications of the results are outlined.
				
					 
				
					Key words: Metals, alloys, coliforms, Escherichia coli.
Identification of beta-1,6-glucosylated cell wall proteins in yeast and hyphal forms of Candida albicans. (1994)

Several cell wall proteins released from yeast and hyphal cells of Candida albicans by laminarinase reacted with an affinity-purified antiserum raised against beta-1,6-glucan. Binding of the antiserum was competitively inhibited by beta-1,6-glucan, but not by beta-1,3-glucan or isolated N-chains. Immunodetection was completely abolished when the proteins were treated with periodate. These results demonstrate that the laminarinase-released wall proteins of C. albicans possess an epitope consisting of beta-1,6-linked glucose residues. The yeast form of C. albicans contained four beta-1,6-glucosylated wall proteins, an Endo H-resistant protein of 125 kDa and three glycoproteins which became only detectable after Endo H digestion and had a molecular mass of 320, 170 and 44 kDa, respectively. As for the hyphal form, a different set of beta-1,6-glucosylated wall proteins was found consisting of two Endo H-resistant glycoproteins of 125 and 80 kDa, respectively, and two glycoproteins that after Endo H digestion had a molecular mass of 320 and 38 kDa, respectively. Sodium dodecyl sulfate-extractable wall proteins and medium proteins did not react with the beta-1,6-glucan antiserum. The beta-1,6-glucan epitope could be removed by aqueous hydrofluoric acid indicating that the epitope is phosphodiester-linked to the cell wall proteins. It is speculated that the epitope forms part of a GPI-anchor and might be involved in the anchoring of mannoproteins into the cell wall.
More "Small Things Forgotten": Domestic Electrical Plugs and Receptacles, 1881-1931 (1986)

The household, wrote A. E. Kennelly in 1890, in itself the condensed history of a nation's past, the centre of its present, and the cradle of its future.' Such a microcosm would certainly seem to deserve detailed study. And, when properly read, household artifacts ought therefore to disclose more than another page in the history of decorative arts and furnishings, for there is also a technology that underlies the ornamentation of domestic life. Domestic technology has certainly not been neglected by historians, yet a close look at one family of artifacts reveals something important about the nation's past, a legacy that continues to be central today.2
On the Linearity and Efficiency of Outphasing Microwave Amplifiers (2004)

A new approach for the analysis of the efficiency and linearity of Chireix-outphasing combiners is presented. The approach takes into account, in an explicit manner, the effect of impedance mismatch between the amplifiers and the lossless combining structure. It is shown that the impedance mismatch leads to new expressions for the output voltages from both branches of the amplifier. These expressions explain the origin of the lack of linearity reported in the literature for the Chireix architecture and lead to a new expression for the instantaneous efficiency of a Chireix combiner. Various simulations using a commercial simulator are performed and their results are compared to those predicted by the derived equations. A quasi-exact agreement between the simulator and derived equations is found for all simulations conducted, including voltage expressions, linearity analysis, and instantaneous and average efficiency calculations for a code-division multiple-access signal. The impact of combiner parameters on its linearity and efficiency is also studied.
Securing passwords against dictionary attacks (2002)

The use of passwords is a major point of vulnerability in computer security, as passwords are often easy to guess by automated programs running dictionary attacks. Passwords remain the most widely used authentication method despite their well-known security weaknesses. User authentication is clearly a practical problem. From the perspective of a service provider this problem needs to be solved within real-world constraints such as the available hardware and software infrastructures. From a user's perspective user-friendliness is a key requirement.In this paper we suggest a novel authentication scheme that preserves the advantages of conventional password authentication, while simultaneously raising the costs of online dictionary attacks by orders of magnitude. The proposed scheme is easy to implement and overcomes some of the difficulties of previously suggested methods of improving the security of user authentication schemes.Our key idea is to efficiently combine traditional password authentication with a challenge that is very easy to answer by human users, but is (almost) infeasible for automated programs attempting to run dictionary attacks. This is done without affecting the usability of the system. The proposed scheme also provides better protection against denial of service attacks against user accounts.
A 256K NMOS DRAM (1984)

A 80ns 256K n-channel metal-gate DRAM with tour selectable data I/O buffers which permit the chip to be used as 64K×4, 128 × 2, or 256 × 1, with either parallel or serial data transfer at 20ns data rate, will be discussed.
Comparison of Nine Fusion Techniques for Very High Resolution Data (2008)

The term covers multiple techniques used to combine the geometric detail of a high-resolution panchromatic image and the color information of a low-resolution multispectral image to produce a final image with the highest possible spatial information content while still preserving good spectral information quality. During the last twenty years, many methods such as Principal Component Analysis (PCA), Multiplicative Transform, Brovey Transform, and IHS Transform have been developed producing good quality fused images. Despite the quite good visual results, many research papers have reported the limitations of the above fusion techniques. The most significant problem is color distortion. Another common problem is that the fusion quality often depends upon the operator's fusion experience and upon the data set being fused. In this study, we compare the efficiency of nine fusion techniques and more specifically the efficiency of IHS, Modified IHS, PCA, Pansharp, Wavelet, LMM (Local Mean Matching), LMVM (Local Mean and Variance Matching), Brovey, and Multiplicative fusion techniques for the fusion of QuickBird data. The suitability of these fusion techniques for various applications depends on the spectral and spatial quality of the fused images. In order to quantitatively measure the quality of the fused images, we have made the following controls. First, we have examined the visual qualitative result. Then, we examined the correlation between the original multispectral and the fused images and all the statistical parameters of the histograms of the various frequency bands. Finally, we performed an unsupervised classification, and we compared the resulting images. All the fusion techniques improve the resolution and the visual result. The resampling method practically has no effect on the final visual result. The LMVM, the LMM, the Pansharp, and the Wavelet merging technique do not change the statistical parameters of the original images. The Modified IHS provokes minor changes to the statistical parameters than the classical IHS or than the PCA. After all the controls, the LMVM, the LMM, the Pansharp, and the Modified IHS algorithm seem to gather the more advantages in fusion panchromatic and multispectral data.
Observation of Accelerating Airy Beams (2007)

We report the first observation of Airy optical beams. This intriguing class of wave packets, initially predicted by Berry and Balazs in 1979, has been realized in both one- and two-dimensional configurations. As demonstrated in our experiments, these Airy beams can exhibit unusual features such as the ability to remain diffraction-free over long distances while they tend to freely accelerate during propagation.
Development of a Flow Injection Capillary Chemiluminescent ELISA Using an Imprinted Polymer Instead of the Antibody (2001)

A flow injection competitive assay analogous to enzyme immunoassays has been developed using a molecularly imprinted polymer instead of the antibody. A glass capillary was modified by covalently attaching an imprinted polymer to the inner capillary wall. The herbicide 2,4-dichlorophenoxyacetic acid was used as a model analyte. The analyte was labeled with tobacco peroxidase, and chemiluminescence was used for detection in combination with a photomultiplier tube or a CCD camera. In a competitive mode, the analyte-peroxidase conjugate was passed together with the free analyte through the polymer-coated capillary mounted in a flow system. After a washing step, the chemiluminescent substrate was injected and the bound fraction of the conjugate was quantified by measuring the intensity of the emitted light. Calibration curves corresponding to analyte concentrations ranging from 0.5 ng mL(-1) to 50 microg mL(-1) (2.25 nM-225 microM) were obtained. A lowered detection limit by 2 orders of magnitude was obtained when detection was done in discontinuous mode and the chemiluminescence light was conducted inside the photomultiplier tube by an optical fiber bundle, thus yielding a dynamic range of 5 pg mL(-1)-100 ng mL(-1) (22.5 pM-450 nM).
Synthesis and Turnover of Protein-Bound N<sup>t</sup>-Methylhistidine in Cultured Vascular Smooth Muscle Cells (1985)

Rabbit aortic smooth muscle cells cultured for 14 days in second passage produce significant amounts of protein-bound radioactive Nt-methylhistidine when pulsed with radiolabelled histidine. Much of the radioactive Nt-methylhistidine is located in the actin synthesized by these cells. Pulse chase data also suggest this newly synthesized Nt-methylhistidine disappears from the cell layer at two distinctly different rates: one with a half-life of 2.4 days, and the other with a half-life of approximately 17 days. Radioactive Nt-methylhistidine to histidine ratio reaches a maximum approximately 8 days following the 1-day [14C]histidine pulse. During the initial 15-day chase period, there is a substantial net accumulation of total Nt-methylhistidine in the culture flasks. The data presented in this communication indicate that methods to evaluate Nt-methylhistidine synthesis and disappearance in cultures are feasible when radiolabelled histidine is employed.
Active sodium transport and alveolar epithelial Na-K-ATPase increase during subacute hyperoxia in rats (1994)

Active Na+ transport and lung edema clearance were studied in a model of lung injury caused by sublethal oxygen exposure. Rats exposed to 85% O2 for 7 days were studied at 0, 7, 14, and 30 days after removal from the hyperoxic chamber and compared with room air controls. In the isolated-perfused, fluid-filled rat lung, albumin flux from the perfusate into the air spaces increased after oxygen exposure and returned to control values after 7 days of recovery. However, permeability to small solutes (Na+ and mannitol) normalized only after 30 days of recovery from hyperoxia. Active Na+ transport increased immediately after oxygen exposure and returned to control values 7 days after removal from hyperoxic chamber. Na-K-adenosinetriphosphatase (ATPase) activity, and protein expression in alveolar epithelial type II cells obtained at the end of the isolated lung experiments increased significantly after the oxygen exposure compared with controls in association with the increased active Na+ transport. We conclude that active Na+ transport and lung liquid clearance are increased in the subacute hyperoxic phase of lung injury in rats, due in part to the upregulation of alveolar epithelial Na-K-ATPases. Conceivably, this behavior protects against the effects of lung injury by allowing the injured lung to clear edema more effectively. Accordingly, this upregulation may be targeted as a strategy to diminish edema in patients with lung injury.
Indirect calculation of breast tissue impedance values (2002)

One of the problems facing anyone attempting the investigation of dielectric properties of living tissue is the presence of skin, which screens all that lies under it from direct measurement. Thus, in non-invasive breast examination using transimpedance measurements, skin parameters heavily influence the results, specifically at low (less than 10 kHz) frequencies. In this paper a method for overcoming this difficulty by using multi-frequency measurements obtained from a surface current distribution over a flat probe is described. By using the variation in the shape of the real and imaginary parts of the surface current density at different frequencies, the original dielectric values of the skin and the underlying tissue can be obtained, based on the assumption of the existence of a two-layer geometry, with the upper (skin) layer much thinner than the lower (tissue) layer. The results obtained can be used in the diagnosis of breast cancer using existing transimpedance measurement devices.
Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts. (2003)

Methoxyamine (MX) has been shown to potentiate the antitumor effect of temozolomide (TMZ) in human tumor xenograft models. This potentiation is due to the reactivity of MX with apurinic/pyrimidinic (AP) sites in DNA, which are formed following DNA glycosylase removal of TMZ-induced methyl-purine adducts. MX-bound AP sites cannot be further processed by base excision repair (BER), resulting in cell death. On the basis of this finding, we investigated in vivo whether MX enhanced therapeutic efficacy of other agents, such as 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) that generates AP sites during DNA repair. Nude mice carrying human colon tumor xenografts, HCT116 and HCT116-Ch3, were treated by a single injection (i.p) of BCNU alone (30 mg/kg) or MX (2 mg/kg) combined with BCNU. The effect on tumor growth of BCNU alone was very moderate. Combined administration of MX and BCNU produced significant inhibition of tumor growth. Tumor growth delays were 14 +/- 3 days in HCT116 and 16 +/- 2 days in HCT116-Ch3 tumors, respectively (P < 0.05 versus control or BCNU alone groups). Similar results were also observed in SW480 and DLD1 tumors. Importantly, no systemic toxicity was noted with BCNU and MX. In contrast, BCNU (at dose of 25 mg/kg) combined with O(6)-benzylguanine (BG), an inhibitor of O(6)-alkylguanine-DNA alkyltransferase (AGT) being tested in clinical trials, caused toxic death in all treated mice. However, a lower dose BCNU (10 mg/kg) combined with BG and MX had significant antitumor effect without toxic death. Thus, targeting BER with MX is a promising strategy to improve the antitumor activity of BCNU and perhaps other DNA-damaging agents.
In-band OSNR Monitor for DP-QPSK Signal with High-speed Integrated Stokes Polarimeter (2012)

We propose an in-band OSNR monitor based on high-speed polarization analysis. We fabricated a high-speed integrated Stokes polarimeter with a PLC-based polarization filter, high-speed photodiodes and trans-impedance amplifiers, and carried out proof-of-concept experiments with 100-Gb/s DP-QPSK signals.
Performance and reliability study for distributed video servers: mirroring or parity? (2003)

We study video server performance and reliability. We classify several reliability schemes based on the redundancy technique used (mirroring vs. parity) and of the distribution granularity of redundant data. Then, we propose for each scheme its adequate data layout. To calculate the server reliability we apply discrete modeling based on Markov chains. Further we focus on the trade-off between achieving high reliability and low per stream cost. Our results show that, in contrast to intuition, for the same degree of reliability mirroring-based schemes always outperform parity-based schemes in terms of per stream cost and also restart latency after disk failure. Our results also show that a mirroring scheme that copies original data of a single disk onto a subset of all disks significantly improves the server reliability and slightly increases the per stream cost as compared to the classical interleaved mirroring scheme.
Charge-density study on cyclosporine A (2009)

Two single-crystal X-ray diffraction data sets of cyclosporine A were measured to high resolution using synchrotron radiation at temperatures of 5 and 90 K. They allowed an accurate determination of its molecular and electronic structure. Three electron-density models based on pseudoatom scattering factors were compared in terms of derived bond topological properties and in terms of electron-density differences on a grid. In one model multipole parameters were freely refined, whereas in the other two models the density was built up from fixed database parameters from the invariom database and University at Buffalo Databank. The data quality not only allowed benchmarking of the quality of both databases with the refined density, but also judgement of the feasibility of a multipole refinement of a larger oligopeptide structure such as cyclosporine A. Both databases performed equally well and reproduced the experimentally determined charge density satisfactorily.