gebhart/patrepeval huggingface dataset:
Strain-enhanced photoluminescence from Ge direct transition (2010)

Strong enhancement of Ge direct transition by biaxial-tensile strain was observed. The reduction in band gap difference between the direct and indirect valleys by biaxial tensile strain increases the electron population in the direct valley, and enhances the direct transition. The band gap reduction in the direct and indirect valleys can be extracted from the photoluminescence spectra and is consistent with the calculations using k⋅p and deformation potential methods for conduction bands and valence bands, respectively.
Nonlinear acoustic echo cancellation based on a parallel-cascade kernel affine projection algorithm (2012)

In acoustic echo cancellation (AEC) applications, oftentimes an acoustic path from a loudspeaker to a microphone is estimated by means of a linear adaptive filter. However, loudspeakers introduce nonlinear distortions which may strongly degrade the adaptive filter performance, thus nonlinear filters have to be considered. This paper proposes two adaptive algorithms namely the parallel and cascade sliding-window kernel based affine projection algorithm (PSW-KAPA and CSW-KAPA) to solve the problem of nonlinear AEC (NLAEC) while keeping the computational complexity low. They are based on a leaky KAPA which employs the theory and algorithms of kernel methods. The basic concept is to perform adaptive filtering in a linear space that is nonlinearly related to the original input space. A kernel specifically designed for acoustic applications is proposed, which consists in a weighted sum of the linear and the Gaussian kernels. The motivation is basically to separate the problem into linear and nonlinear subproblems. The weights in the kernel also impose different forgetting mechanisms in the sliding window which in turn translates to a more flexible regularization. Simulation results show that PSW-KAPA and CSW-KAPA consistently outperform the linear NLMS, and generalize well both in high and low linear to nonlinear ratio (LNLR).
Synthesis of some 2(H),4(H)-1,2,4-Triazino[3,4-c]-1,4-benzoxazin-5-ones (1988)

Department of Chemistry, Shivaji University, Kolhapur-416 004 <em>Manuscript received 29 February 1988, revised 31 May 1988, accepted 18 July 1988</em> Synthesis of some 2(<em>H</em>),4(<em>H</em>)-1,2,4-Triazino[3,4-<em>c</em>]-1,4-benzoxazin-5-ones.
A stabilized driftless analog integrator (1954)

A new chopper-stabilized analog integrator circui, has been developed which, at the cost of two passive elementts enables the stabilizer amplifier to operate on the output drift due to input current as well as the drift due to unbalance.
Cryo-electron microscopy and three-dimensional reconstruction of the calcium release channel/ryanodine receptor from skeletal muscle. (1994)

The calcium release channel (CRC) from skeletal muscle is an unusually large tetrameric ion channel of the sarcoplasmic reticulum, and it is a major component of the triad junction, the site of excitation contraction coupling. The three-dimensional architecture of the CRC was determined from a random conical tilt series of images extracted from electron micrographs of isolated detergent-solubilized channels prepared in a frozen-hydrated state. Three major classes of fourfold symmetric images were identified, and three-dimensional reconstructions were determined for two of these. The two independent reconstructions were almost identical, being related to each other by a 180 degrees rotation about an axis in the plane of the specimen grid. The CRC consists of a large cytoplasmic assembly (29 x 29 x 12 nm) and a smaller transmembrane assembly that protrudes 7 nm from one of its faces. A cylindrical low-density region, 2-3 nm in apparent diameter, extends down the center of the transmembrane assembly, and possibly corresponds to the transmembrane Ca(2+)-conducting pathway. At its cytoplasmic end this channel-like feature appears to be plugged by a globular mass of density. The cytoplasmic assembly is apparently constructed from 10 or more domains that are loosely packed together such that greater than 50% of the volume enveloped by the assembly is occupied by solvent. The cytoplasmic assembly is suggestive of a scaffolding and seems well adapted to maintain the structural integrity of the triad junction while allowing ions to freely diffuse to and away from the transmembrane assembly.
High-speed wet etching of through silicon vias (TSVs) in micro- and nanoscale (2014)

In this paper, a novel wet etching method, named metal-assisted chemical etching (MaCE), is applied for through silicon vias (TSVs) fabrications. The influence of key experimental parameters in MaCE, including catalyst, etchant and dimension of TSVs are discussed. Especially, the type, geometry and morphology of catalyst are varied and the results are compared. A high etching rate over 10 μm/min and a high aspect ratio over 100 are observed in sub-micron scale TSV etching. The presented data demonstrates that MaCE is a promising candidate for TSVs etching with high speed, high aspect ratio capability, submicron capability and low cost.
Maternal glycemic criteria for insulin therapy in gestational diabetes mellitus. (1998)

In the last decade, it has become clear that gestational diabetes is a clinical entity associated with perinatal mortality and morbidity. Thus, the attention to and management of gestational diabetes during pregnancy are mandatory. In this review, results of 58 original studies (spanning the past 20 years) addressing criteria for insulin management in gestational diabetes were assessed. The level of glycemic control and its evaluation through self-monitoring of blood glucose are the foundation for ascertaining optimal pregnancy outcome. This review addresses the criteria for insulin initiation: insulin requirements, identification of the right patient, the timing for insulin initiation, and the behavioral adjustment and compliance during insulin therapy. It is recommended that patients with fasting plasma glucose on the oral glucose tolerance test (OGTT) of < 96 mg/dl (and ideally nonobese) be assigned to diet therapy. Obese women or those with fasting plasma glucose > 95 mg/dl on the OGTT should be referred to insulin therapy in order to minimize exposure of the fetus to a hyperglycemic environment.
The role of the bridging group in exchange coupling in dinuclear homo- and heterometallic Ni(ii) and Co(ii) complexes with oxalate, oxamidate and dithiooxamidate bridges (2012)

Six homodinuclear and two heteronuclear complexes Tp(Np)Co-C(2)O(4)-CoTp(Np) (1), Tp(Np)Co-C(2)O(4)-NiTp(Cy) (2), Tp(Cy)Ni-C(2)O(4)-NiTp(Cy) (3), Tp(Np)Co-C(2)O(2)(NH)(2)-CoTp(Np) (4), Tp(Cy)Ni-C(2)O(2)(NH)(2)-NiTp(Cy) (5), Tp(Np)Co-C(2)S(2)(NH)(2)-CoTp(Np) (6), Tp(Np)Co-C(2)S(2)(NH)(2)-NiTp(Cy) (7), Tp(Cy)Ni-C(2)S(2)(NH)(2)-NiTp(Cy) (8) (Tp(Np) = tris(3-neopentylpyrazolyl)borate, Tp(Cy) = tris(3-cyclohexylpyrazolyl)borate), were synthesized and characterized by mass spectrometry, electronic spectroscopy and X-ray crystallography. These compounds possess similar molecular structures, with the metal ions linked by bridging oxalate (1-3), oxamidate (4 and 5) or dithiooxamidate (6-8) ions. The heteronuclear nature of compounds 2 and 7 was additionally confirmed by high-resolution mass spectrometry. The magnetic properties of the Co(2+) complexes were modelled taking into account zero-field splitting of this ion, yielding D-values for Co(2+) in the range -17(1) to -50(1) cm(-1). All the metal ion pairs in compounds 1-8 are antiferromagnetically-coupled, with J values between -10.0(1) and -45.0(2) cm(-1) (via the exchange Hamiltonian Ĥ(ex.) = -2JŜ(1)Ŝ(2)) and |J| increasing in the order oxalate < oxamidate < dithiooxamidate. This tendency can be attributed to greater M-S bond covalency compared to M-N or M-O bonds (M = Co(2+) and Ni(2+)). It was found that this antiferromagnetic coupling of Co(2+) and Ni(2+) ions through oxalate is more efficient for these tris(pyrazolyl)borate complexes than for similar oxalate-bridged systems with neutral aliphatic amine ligands.
Calibrated oscilloscopic system for RF time-domain characterization of non-linear devices (2013)

This paper proposes a fully calibrated four channel high sampling rate oscilloscopic system based on the use of Track and Hold Amplifiers. The system achieves a high equivalent sampling rate (up to 1THz) using coherent interleaved sampling principle. An accurate calibration procedure allows a 10 kHz resolution over a 3 GHz bandwidth is applied. The capabilities of the system are presented and validated by characterizing a bandpass filter and an S-band 50 W GaN high power broadband amplifier under wideband CW pulsed signal excitation. S-parameters and power characteristics measurements are also presented. The fully calibrated system has the capability to give an accurate visualization of time-domain distortions of input/output voltage and current waveforms within the pulse. It also allows the determination of rising and falling transitions times of the pulse.
On the Parameter Estimation and Modeling of Aggregate Power System Loads (2004)

This paper addressed some theoretical and practical issues relevant to the problem of power system load modeling and identification. Two identification techniques are developed in the theoretical framework of stochastic system identification. The identification techniques presented in this paper belong to the family of output error models; both techniques are based on well-established equations describing load recovery mechanisms having a commonly recognized physical appeal. Numerical experiments with artificially created data were first performed on the proposed techniques and the estimates obtained proved to be asymptotically unbiased and achieved the corresponding Crame/spl acute/r-Rao lower bound. The proposed techniques were then tested using actual field measurements taken at a paper mill, and the corresponding results were used to validate a commonly used aggregate load model. The results reported in this paper indicate that the existing load models satisfactorily describe the actual behavior of the physical load and can be reliably estimated using the identification techniques presented herein.
Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila. (1993)

The Drosophila Notch gene product is a transmembrane protein that functions as a receptor of intercellular signals in several Drosophila developmental processes. Two other transmembrane proteins, encoded by the genes Delta and Serrate, genetically and molecularly behave as Notch ligands. All these proteins share the presence of epidermal growth factor (EGF)-like repeats in their extracellular domain. The Notch protein has 36 EGF-like repeats, 2 of which, numbers 11 and 12, are required for the interaction with the Delta and Serrate ligands. We have isolated and molecularly characterized a Notch mutation in its Delta- and Serrate-binding domain that behaves genetically as both a Notch antimorphic and a loss-of-function mutation. This mutation, NM1, carries a Glu-->Val substitution in the Notch EGF repeat 12. The NM1 allele interacts with other Notch alleles such as Abruptex and split and with mutations in the Notch-ligand genes Delta and Serrate. The basis for the genetic antimorphism of NM1 seems to reside in the titration of Notch wild-type products into NM1/N+ nonfunctional dimers and/or the titration of Delta products into nonfunctional ligand-receptor complexes.
Sugar sensing by enterocytes combines polarity, membrane bound detectors and sugar metabolism (2007)

Sugar consumption and subsequent sugar metabolism are known to regulate the expression of genes involved in intestinal sugar absorption and delivery. Here we investigate the hypothesis that sugar-sensing detectors in membranes facing the intestinal lumen or the bloodstream can also modulate intestinal sugar absorption. We used wild-type and GLUT2-null mice, to show that dietary sugars stimulate the expression of sucrase-isomaltase (SI) and L-pyruvate kinase (L-PK) by GLUT2-dependent mechanisms, whereas the expression of GLUT5 and SGLT1, did not rely on the presence of GLUT2. By providing sugar metabolites, sugar transporters, including GLUT2, fuelled a sensing pathway. In Caco2/TC7 enterocytes, we could disconnect the sensing triggered by detector from that produced by metabolism, and found that GLUT2 generated a metabolism-independent pathway to stimulate the expression of SI and L-PK. In cultured enterocytes, both apical and basolateral fructose could increase the expression of GLUT5, conversely, basolateral sugar administration could stimulate the expression of GLUT2. Finally, we located the sweet-taste receptors T1R3 and T1R2 in plasma membranes, and we measured their cognate G alpha Gustducin mRNA levels. Furthermore, we showed that a T1R3 inhibitor altered the fructose-induced expression of SGLT1, GLUT5, and L-PK. Intestinal gene expression is thus controlled by a combination of at least three sugar-signaling pathways triggered by sugar metabolites and membrane sugar receptors that, according to membrane location, determine sugar-sensing polarity. This provides a rationale for how intestine adapts sugar delivery to blood and dietary sugar provision.
Generating pseudo-exhaustive vectors for external testing (2002)

Over the past years special chips for external tests have been successfully used for random pattern testing. The authors present a technique for combining the advantages of such a low-cost test with the advantages of pseudoexhaustive testing, which are enhanced fault coverage and simplified test pattern generation. To achieve this goal, two tasks are accomplished. First, an algorithm is developed for pseudoexhaustive test pattern generation, which ensures a feasible test length. Second, a chip design for applying these test patterns to a device under test is presented. The chip is programmed by the output of the proposed algorithm and controls the entire test. The technique is first applied to devices with a scan path and then extended to sequential circuits. A large number of benchmark circuits have been investigated, and the results are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Unumgängliche sozial- und bodenrechtliche Vorbedingungen erfolgreicher regionaler Entwicklung (1966)

Lange Zeit hindurch hat sich der moderne Wirtschattsautbau der Entwicklungsländer überwiegend in der Weise vollzogen, daß einzelne Produktionszweige aus den alten Industriestaaten dorthin verlagert wurden, weil diese Verlagerung nach dem Gesetz der komparativen Kosten angebracht erschien. Die jungen Volkswirtschaften wurden damit einseitig entwickelt, ohne ihre Gesamtheit in einen arbeitsteiligen Prozeß einzubeziehen. So konnten diese Länder nicht in aller Breite, sondern nur punktuell in Ergänzung der Wirtschaft europäisch-amerikanischer Länder ökonomisch vorankommen.
Regulation of Secondary Antigen-Specific CD8+ T-Cell Responses by Natural Killer T Cells (2009)

The physiologic function of natural killer T (NKT) cells in adaptive immunity remains largely unknown because most studies have used NKT cell agonists. In the present study, the role of NKT cells during the secondary effector phase was investigated separately from the primary immunization phase via adoptive transfer of differentiated effector T cells into naive recipients. We found that secondary antitumor CD8(+) T-cell responses were optimal when NKT cells were present. Tumor-specific CD8(+) effector T cells responded less strongly to tumor cell challenge in NKT cell-deficient recipients than in recipients with intact NKT cells. NKT cell-mediated enhancement of the secondary antitumor CD8(+) T-cell response was concurrent with increased number and activity of tumor-specific CD8(+) T cells. These findings provide the first demonstration of a direct role for NKT cells in the regulation of antigen-specific secondary T-cell responses without the use of exogenous NKT cell agonists such as alpha-galactosylceramide (alpha-GalCer). Furthermore, forced activation of NKT cells with alpha-GalCer during the secondary immune response in suboptimally immunized animals enhanced otherwise poor tumor rejection responses. Taken together, our findings strongly emphasize the importance of NKT cells in secondary CD8(+) T-cell immune responses.
Identification and characterization of a novel member of the EXT gene family, EXTL2. (1998)

Recently, two homologous genes, EXT1 and EXT2, with a putative tumor suppressor function have been described. Mutations in both genes are responsible for multiple exostosis syndrome (EXT), an autosomal dominant condition characterized by the presence of multiple osteochondromas, bony excrescences that sometimes undergo malignant transformation to chondrosarcoma. This family of EXT genes has been extended by the identification of an EXT-like (EXTL) gene showing a high degree of homology with the EXT genes. We report here a second EXT-like gene (EXTL2) which is homologous to the EXT and EXTL genes. EXTL2 consists of 5 exons encoding an ubiquitously expressed protein of 330 amino acids. In addition, a putative pseudogene, EXTL2P was also identified. The EXTL2 gene was assigned to chromosome 1p11-p12, whereas EXTL2P was mapped on chromosome 2q24-q31.
Split-path enhanced pipeline scheduling for loops with control flows (1998)

Software pipelining increases the loop execution throughput by overlapping the execution of successive iterations in a pipelined fashion. For loops with control flows, software pipelining is not straightforward because we need to consider the overlap of more than one execution path. Modulo scheduling simply transforms them into straight-line loops through if-conversion which, in effect, achieves a fixed, worst-case initiation interval (II) among all paths. All-path pipelining (APP) and enhanced pipeline scheduling (EPS) can achieve a variable II depending on the path that is followed through the loop at execution time. Unfortunately, APP concentrates only on the overlap within the same path, entirely losing the overlap between different paths, whereas EPS attempts to overlap all future paths together, failing to produce a tight schedule for each individual path. In this paper, we propose a new approach to EPS which splits each individual path in the loop via tail duplication, and performs EPS in a way to guarantee a tight schedule within the same path, while producing a comparable cross-path schedule. Our experimental results indicate that the proposed technique can achieve as much as a geometric mean of 7% performance improvement on non-trivial integer benchmarks.
Needle-Free Jet Injection of Rapid-Acting Insulin Improves Early Postprandial Glucose Control in Patients With Diabetes (2013)

The considerably more rapid insulin absorption after administration by jet injector translated to a significant if modest decrease in postprandial hyperglycemia in patients with type 1 and type 2 diabetes. The improved early postprandial glucose control may specifically benefit patients who have difficulty in limiting postprandial glucose excursions.
A Summary Review of Wireless Sensors and Sensor Networks for Structural Health Monitoring (2006)

In recent years, there has been an increasing interest in the adoption of emerging sensing technologies for instrumentation within a variety of structural systems. Wireless sensors and sensor networks are emerging as sensing paradigms that the structural engineering field has begun to consider as substitutes for traditional tethered monitoring systems. A benefit of wireless structural monitoring systems is that they are inexpensive to install because extensive wiring is no longer required between sensors and the data acquisition system. Researchers are discovering that wireless sensors are an exciting technology that should not be viewed as simply a substitute for traditional tethered monitoring systems. Rather, wireless sensors can play greater roles in the processing of structural response data; this feature can be utilized to screen data for signs of structural damage. Also, wireless sensors have limitations that require novel system architectures and modes of operation. This paper is intended to serve as a summary review of the collective experience the structural engineering community has gained from the use of wireless sensors and sensor networks for monitoring structural performance and health.
Imaging Intratumoral Convection: Pressure-Dependent Enhancement in Chemotherapeutic Delivery to Solid Tumors (2008)

These data indicate that the modulation of convective flow within tumors can improve the delivery of (LMW) chemotherapeutics and show the potential role for noninvasive imaging of this process in vivo.
Ubiquitination of HEXIM1 by HDM2 (2009)

Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) is an inhibitor of the positive transcription elongation factor b (P-TEFb), which controls RNA polymerase II transcription and human immunodeficiency virus Tat transactivation. In cells, more than half of P-TEFb is associated with HEXIM1 resulting in the inactivation of P-TEFb. Recently, we found that nucleophosmin (NPM), a key factor involved in p53 signaling pathway, interacts with HEXIM1 and activates P-TEFb-dependent transcription. Here we report that human double minute-2 protein (HDM2), a p53-specific E3 ubiquitin ligase, specifically ubiquitinates HEXIM1 through the lysine residues located within the basic region of HEXIM1. However, the HDM2-induced HEXIM1 ubiquitination does not lead to proteasome-mediated protein degradation. Fusion of ubiquitin to HEXIM1 demonstrates stronger inhibition on P-TEFb-dependent transcription. Our results demonstrate that HDM2 functions as a specific E3 ubiquitin ligase for HEXIM1, suggesting a possible role for HEXIM1 ubiquitination in the regulation of P-TEFb activity.
Towards application-aware anonymous routing (2007)

This paper investigates the problem of designing anonymity networks that meet application-specific performance and security constraints. We argue that existing anonymity networks take a narrow view of performance by considering only the strength of the offered anonymity. However, real-world applications impose a myriad of communication requirements, including end-to-end bandwidth and latency, trustworthiness of intermediary routers, and network jitter. We pose a grand challenge for anonymity: the development of a network architecture that enables applications to customize routes that tradeoff between anonymity and performance. Towards this challenge, we present the Application-Aware Anonymity (A 3) routing service. We envision that A 3 will serve as a powerful and flexible anonymous communications layer that will spur the future development of anonymity services. 1
Direct regulation of bile secretion by prostaglandins in perfused rat liver (1994)

Prostaglandins have been postulated to act as mediators of intercellular communication between liver cell populations in the regulation of liver carbohydrate metabolism. Their role in the regulation of bile secretion is rather unclear. The action of prostaglandins on bile flow and bile acid secretion was studied in the in situ perfused rat liver. Infusion of prostaglandin F2 alpha resulted in reduction of bile flow and bile acid secretion. In addition, portal flow was diminished and glucose output was increased. The parameters were altered in a dose-dependent manner. The effects of prostaglandins D2 and E2 were similar but less potent than those of prostaglandin F2 alpha. To separate the effects on portal flow and bile flow, we used nitroprusside and nifedipine to suppress the hemodynamic changes induced by prostaglandins. In the presence of these substances, the alterations of bile flow and bile acid secretion were even more pronounced. Infusion of inhibitors of prostaglandin synthesis increased bile flow. In conclusion, prostaglandins F2 alpha, D2 and E2 reduce bile flow and bile acid secretion. These effects are independent of hemodynamic changes. Suppression of synthesis of endogenous prostaglandins by inhibitors of prostaglandin synthesis reversed these effects. Prostaglandins are involved in the regulation of bile flow and bile acid secretion.