gebhart/patrepeval huggingface dataset:
3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19) (2008)

Wnt signalling is one of the fundamental cell communication systems operating in the embryo and the collection of 19 Wnt and 10 Frizzled (Fzd) receptor genes (in mouse and human) represent just part of a complex system to be unravelled. Here we present a spatially comprehensive set of data on the 3D distribution of Wnt and Fzd gene expression patterns at a carefully selected single stage of mouse development. Overviews and selected features of the patterns are presented and the full 3D data set, generated by fully described probes, is available to the research community through the Edinburgh Mouse Atlas of Gene Expression. In addition to being comprehensive, the data set has been generated and recorded in a consistent manner to facilitate comparisons between gene expression patterns with the capacity to generate matching virtual sections from the 3D representations for specific studies. Expression patterns in the left forelimb were selected for more detailed comparative description. In addition to confirming the previously published expression of these genes, our whole embryo and limb bud analyses significantly extend the data in terms of details of the patterns and the addition of previously undetected sites of expression. Our focussed analysis of expression domains in the limb, defined by just two gene families, reveals a surprisingly high degree of spatial complexity and underlines the enormous potential for local cellular interactions that exist within an emerging structure. This work also highlights the use of OPT to generate detailed high-quality, spatially complex expression data that is readily comparable between specimens and can be reviewed and reanalysed as required for specific studies. It represents a core set of data that will be extended with additional stages of development and through addition of potentially interacting genes and ultimately other cross-regulatory communication pathways operating in the embryo.
First demonstration of SAW propagation in organic crystal (1992)

(−)−2−α-methylbenzylamino-5-nitropyridine (MBANP) forms a monoclinic crystal with symmetry point group 2 [1]. The material is capable of being piezoelectric [2] and has therefore been considered as a material for SAW device fabrication. To the best of the authors' knowledge, this is the first demonstration of SAW propagation in a polar organic crystal, indicating a new class of material for signal processing applications. A SAW velocity of 1416 ms−1 in the [010] direction was measured, which is typically a factor of two lower than for many inorganic substrates.
Geocoding Data Analysis and Processing in Relational Databases (2014)

Geocoding data are widely used in applications to support geographical locations and compute spatial relationships, such as distances. It is a common practice to capture geospatial data in relational database management systems (RDBMS), where most business data are stored and processed. However, RDBMS’s lack of ability in geocoding analysis and processing has prevented applications from handling spatial data effectively. Relational databases need to support geocoding data analysis and processing, such as geocoding data sorting, searching, geo-positioning, and distance computing. More advanced requirements may include the analysis of an area based on geo-location and area coverage of a geo-location. This paper provides analysis of some of the requirements on geocoding data processing in RDBMS from business application perspectives. The challenges in design and implementation will be discussed. The requirements will be further transformed to modeling, analysis, and processing on geocoding support in relational databases. When database volume increases, performance issues need to be addressed in order to provide efficient data queries and data processing. Database objects, such as auxiliary tables, views, and indexes, can be designed to provide performance improvement.
FastProxy: Hardware and Software Acceleration of Stratum Mining Proxy (2019)

The Stratum protocol is the de facto protocol for mining proxies in proof-of-work (PoW) based cryptocurrencies such as Bitcoin. A Stratum mining proxy connects to an upstream mining pool server and to downstream miners through TCP/IP connections. The proxy receives periodic jobs from the pool and broadcasts them to the miners. The broadcast operation becomes a performance and scalability bottleneck when the number of miners increases significantly. In this paper, we propose a hardware/software co-designed architecture for the proxy to accelerate the broadcast of periodic jobs. We customize the Stratum protocol with a layer 2 broadcast mechanism instead of using TCP/IP connections. The proposed architecture is implemented on a Xilinx Zynq SoC (ARM processor and FPGA) board where the layer 2 broadcast mechanism is offloaded on the FPGA. Our experiments demonstrated a speedup of 2079x in transmission time with 225 miners connected to the proxy, compared to an implementation on an Intel i7 server.
Studies of anticancer and antipyretic activity of Bidens pilosa whole plant. (2006)

Screening of different extracts and fractions from the plant Bidens pilosa Linn. var. (Asteraceae) has been conducted using the in-vitro comet assay for anticancer and the antipyretic action, which was done with in-vivo models. The extract from whole plant was extracted with n-hexane, chloroform and methanol extract (E1 - E3). The extracts were fractioned by column chromatography method and fractioned with ethyl acetate, acetone and water (F1 - F3). All the extracts and fractions were tested for anticancer and antipyretic activity. Among extracts E1 shows remarkable anticancer activity and E3 bears maximum antipyretic activity. In the antipyretic activity, paracetamol was used as the standard test drug. The most promising material (LC50 < 1500 microg/ml) was F1 ethyl acetate fractions of methanolic extract and methanolic crude extract of whole plants. However, little correlation was observed in the degree of antipyretic activity between the test drug and standard drug. In conclusion, the extract obtained from the whole plant of Bidens pilosa showed a significant cytotoxic effect to methanolic extract against Hela cells by in vitro method and showed a comparable antipyretic activity effect to paracetamol in rabbit pyrogen test.
Polymeric Conjugates for Drug Delivery (2012)

The field of polymer therapeutics has evolved over the past decade and has resulted in the development of polymer-drug conjugates with a wide variety of architectures and chemical properties. Whereas traditional non-degradable polymeric carriers such as poly(ethylene glycol) (PEG) and N-(2-hydroxypropyl methacrylamide) (HPMA) copolymers have been translated to use in the clinic, functionalized polymer-drug conjugates are increasingly being utilized to obtain biodegradable, stimuli-sensitive, and targeted systems in an attempt to further enhance localized drug delivery and ease of elimination. In addition, the study of conjugates bearing both therapeutic and diagnostic agents has resulted in multifunctional carriers with the potential to both "see and treat" patients. In this paper, the rational design of polymer-drug conjugates will be discussed followed by a review of different classes of conjugates currently under investigation. The design and chemistry used for the synthesis of various conjugates will be presented with additional comments on their potential applications and current developmental status.
Determination of the switching condition in the quantum-well double-heterostructure optoelectronic switch (DOES) (1992)

The switching mechanism in the GaAs/AlGaAs double-heterostructure optoelectronic switching device (DOES) is investigated in the context of the single-quantum-well graded index laser structure. A new charge conservation approach is introduced to explain the switching mechanism responsible for the thyristor-like behavior. Simple results are obtained for design purposes for currents, voltages, charges, and electric fields at the switching conditions. Switching energies are found to be on the order of 0.1-0.5 fJ/ mu m/sup 2/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Moderate-pressure hydrocracking of heavy vacuum gas oils (1986)

Market trends toward increased middle distillate have prompted renewed interest in hydrocracking. Moderate pressure hydrocracking (MPHC) is once-through, single stage hydrocracking process which enables partial conversion of 345 C + vacuum gas oils to low sulfur distillates. Advantages over conventional hydrocracking include lower hydrogen partial pressure and, consequently, much lower hydrogen consumption. Lower pressure is also desirable from the point of view of equipment availability since the process may be operated in low pressure equipment not normally used for hydrocracking. An example of commercial application of a MPHC retrofit of a vacuum gas oil desulfurization unit is given. Catalysts and economics are described for the process. 4 references.
Characterization of a Monoclonal Antibody Directed against <i>Salmonella enterica</i> Serovar Typhimurium and Serovar [4,5,12:i:−] (2009)

Flagellar extracts of Salmonella enterica serovars expressing phase 2 H1 antigenic complex (H:1,2, H:1,5, H:1,6, and H:1,7) and a mutant flagellin obtained by site-directed mutagenesis of the fljB gene from serovar Typhimurium at codon 218, transforming threonine to alanine, expressed in Escherichia coli (fljB218(A)) were used to analyze the H1 antigenic complex. Cross-reactions were detected by Western blotting and dot blotting using commercial polyclonal antibodies against the different wild-type extracts and mutant FljB218(A). Therefore, we produced a monoclonal antibody (MAb), 23D4, isotyped as immunoglobulin M, against H:1,2 S. enterica serovar Typhimurium flagellin. The mutant flagellin was not recognized by this MAb. When a large number of phase 1 and phase 2 flagellin antigens of different serovars were used to characterize the 23D4 MAb, only extracts of serovars Typhimurium and [4,5,12:i:-] reacted. The protein composition of phase 1 and phase 2 extracts and highly purified H:1,2 flagellin from serovar Typhimurium strain LT2 and extract of strain 286 (serovar [4,5,12:i:-]), which reacted with the MAb, was studied. Phase 2 flagellin (FljB(H:1,2)) was detected in phase 1 and phase 2 flagellar heat extracts of serovar Typhimurium and was the single protein identified in all spots of purified H:1,2 flagellin. FliC, FlgK, and other proteins were detected in some immunoreactive spots and in the flagellar extract of serovar [4,5,12:i:-]. Immunoelectron microscopy of complete bacteria with 23D4 showed MAb attachment at the base of flagella, although the MAb failed to recognize the filament of flagella. Nevertheless, the results obtained by the other immunological tests (enzyme-linked immunosorbent assay, Western blotting, and dot blotting) indicate a reaction against flagellins. The epitopes could also be shared by other proteins on spots where FljB is not present, such as aminopeptidase B, isocitrate lyase, InvE, EF-TuA, enolase, DnaK, and others. In conclusion, MAb 23D4 can be useful for detection and diagnostic purposes of S. enterica serovar Typhimurium and serovar [4,5,12:i:-] and could be also helpful for epitope characterization of flagellum-associated antigens.
A SiGe-bipolar down-conversion mixer for a UMTS zero-IF receiver (2002)

A down-conversion I/Q-mixer for a W-CDMA zero-IF receiver implemented in a 75 GHz f/sub t/ bipolar SiGe technology is reported. Including I/Q-generation and biasing, it consumes a supply current of 18 mA from a 2.7 V supply. A voltage gain of 10.2 dB and an IIP3 of 8 dBm have been achieved. Using frequency division to derive the I- and Q-phases for the local oscillator signals results in LO-RF leakage lower than -68 dBm and an IIP2 better than 56 dBm. DC offsets at the I and Q mixer baseband outputs are typically below 5 mV.
The Distribution Characteristics and Contamination of Heavy Metals in Soil from Dalcheon Mine (2008)

The geochemical partitioning of arsenic in contaminated soils from a of wet land and tailing of the abandoned mine is examined. Chemical analysis and sequential extraction method by ultrasound-sonication extraction are applied to investigate the mobility and chemical existence conditions of arsenic as well as heavy metals. The results of this study showed that heavy metals concentration of tailings showed as a following order: Fe > As > Cu > Pb > Cr. The highest metal concentration was recognized in samples less than fraction in their particle sizes. Exchangeable and carbonate fractions in soil samples showed following Cu > As > Pb > Fe > Cr for tailings, and Fe > Pb > Cu > As > Cr for reservoir soils, respectively. Arsenic was bound as exchangeable fraction in tailings and its concentration appeared higher than those of the other metals. Thus, As can be easily dispersed into soil and water environments. The obtained results can be used to design soil remediation plan in the study area and require further detailed study to investigate severe environmental pollution of surface water as well as rivers with respect to heavy metals in terms of speciation analysis of toxic elements such as As and Cr.
94 GHz Subharmonic Mixer Using Beam Lead Diodes (2005)

As part of a diode and mixer development effort,/sup 1/ a low cost subharmonically pumped millimeter-wave mixer design using GaAs beam lead diodes has been developed. It adopts a configuration which incorporates both waveguide and suspended stripline using a low cost Duroid substrate. A DSB noise figure of 8.5 dB has been achieved-using a 47 GHz Gunn local oscillator and 5- to 500-MHz IF amplifier with a 1.5-dB noise figure.
The Chemistry and Biology of Yeasts. (1958)

Uploaded by Plazi for TaxoDros. We do not have abstracts.
Diffusion of methyl ethyl ketone in polysiobutylene: Comparison of spectroscopic and gravimetric techniques (1997)

In this study, vapor sorption FTIR–ATR (Fourier Transform Infrared Attenuated Total Reflectance) spectroscopy was combined with a conventional gravimetric sorption balance to examine diffusion in polymers. Mutual diffusion coefficients of methyl ethyl ketone in polyisobutylene were measured using both methods at various penetrant activities and temperatures in the range 40–60°C. Actual penetrant concentrations were determined from the sorption balance. The diffusion coefficients from the two techniques agree very well with each other. In addition, the diffusivity data from both techniques could be correlated successfully as a function of temperature and concentration with the Vrentas and Duda free-volume model. © 1997 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 35: 1261–1267, 1997
Quality Attributes of Fresh‐Cut Coconut after Supercritical Carbon Dioxide Pasteurization (2013)

The impact of supercritical CO 2 (SC‐CO 2 ) process on the quality attributes of fresh‐cut coconut has been investigated to establish the acceptability of SC‐CO 2 treated products by the consumers. Two process conditions, previously identified as optimal to reduce the microbial content of the product, were studied: 12 MPa, 40°C, 30 min and 12 MPa, 45°C, 15 min. The results highlighted that both conditions induced some effects on product attributes. After 30 min of treatment at 12 MPa and 40°C a decrease of lightness (8%), pH (13%), fat content (24%), total phenol content (29%), flavonoid compounds (49%), antioxidant capacity (30%) and an increase of dry matter (11%) and titratable acidity (51.1%) were observed while polyphenol oxidase (PPO) exhibited 35% and 98.5% inactivation. Peroxidase enzyme activity increased by 77.8% and 30.4% at 12 MPa, 40°C, 30 min and 12 MPa, 45°C, 15 min, respectively. Sensory evaluations revealed no significant differences in appearance, texture, taste, and aroma of treated fresh‐cut coconut compared to the untreated. The study confirms the feasibility of SC‐CO 2 process for the pasteurization of fresh fruits with a firm structure and opens the door to the possibility of exploiting such a technology at industrial level.
Recent Events in Alcoholic Liver Disease V. Effects of ethanol on liver regeneration (2004)

Liver regeneration is necessary to recover from alcoholic liver injury. Herein, we review evidence that ethanol interferes with liver regeneration. Briefly, alcoholic fatty livers demonstrate increased rates of hepatocyte death. The latter provides a regenerative stimulus. However, unlike mature hepatocytes in healthy adult livers, most surviving mature hepatocytes in alcoholic fatty livers cannot replicate. Therefore, less mature cells (progenitors) must differentiate to replace dead hepatocytes. Little is known about the general mechanisms that modulate the differentiation of liver progenitors in adults. Delineation of these mechanisms and clarification of how ethanol influences them might suggest new therapies for alcoholic liver disease.
Cellobiose dehydrogenase enhances <i>Phanerochaete chrysosporium</i> cellobiohydrolase I activity by relieving product inhibition (1998)

The interaction of cellobiose dehydrogenase (CDH) with cellobiohydrolase I (CBH I) in cellulose-grown cultures of Phanerochaete chrysosporium was investigated to clarify the role of CDH in cellulose degradation. Decomposition of bacterial microcrystalline cellulose by CBH I was enhanced significantly in the presence of the CDH/ferricyanide redox-system compared with CBH I alone. To explain this phenomenon, a model system, using p-nitrophenyl-beta-D-cellobioside as a substrate, was elaborated for measurement of CBH I activity with and without the CDH redox-system. The activity of CBH I for hydrolysis of p-nitrophenyl-beta-D-cellobioside was also enhanced in the presence of the redox system. It was found that Km for hydrolysis of p-nitrophenyl-beta-D-cellobioside by CBH I was lower in the presence than in the absence of the CDH/ferricyanide redox-system, 142 microM and 384 microM, respectively, while no significant difference was observed between the k(cat) values. These results indicate that cellulase activity is enhanced by an increased affinity for p-nitrophenyl-beta-D-cellobioside, rather than by an increased hydrolysis rate. This shows that cellobiose, the hydrolysis product, acts as a competitive inhibitor of the interaction between CBH I and p-nitrophenyl-beta-D-cellobioside. This was confirmed by addition of cellobiose, which was found to competitively inhibit hydrolysis of p-nitrophenyl-beta-D-cellobioside by CBH I in the absence of the CDH redox system, and the Ki value for cellobiose inhibition was estimated to be 65 microM. However, this inhibition did not occur if cellobiose was incubated with CDH before addition of CBH I. It was concluded from these results that the reason for the enhancement of CBH I activity in the presence of the CDH redox system was that it relieves competitive inhibition of cellobiose by its oxidation to cellobionolactone.
Photophysical property of a polymeric nanoparticle loaded with an aryl benzyl ester silicon (IV) phthalocyanine (2014)

Because of their excellent near-infrared (NIR) optical properties, phthalocyanines (Pcs) have been regarded as promising therapy agents for fluorescence image-guided drug delivery and noninvasive treatment of tumors by photodynamic therapy (PDT). Nevertheless, phthalocyanines are substantially limited in clinical applications owing to their poor solubility, aggregation and insufficient selectivity for cancer cells. To address these issues, we have developed a novel dendrimer-based theranostic nanoparticle for tumor-targeted delivery of phthalocyanine. The preparation procedure involved the modification of the silicon (IV) phthalocyanine molecule with a dendritic axially substitution, which significantly enhances their photophysical property. In order to improve biocompatibility and tumor-targeted delivery, the hydrophobic dendritic phthalocyanine was encapsulated by diblock amphiphilic copolymer poly (ethylene glycol)-poly (Epsilon-caprolactone) (MPEG-PCL) to form a polymeric nanoparticle. The polymeric nanoparticle is spherical with a diameter at about 90 nm. The photophysical property of the polymeric nanoparticle was studied by UV/Vis and fluorescence spectroscopic methods. Compared with the free dendritic phthalocyanine, the Q band of the polymeric nanoparticle was red-shifted, and the fluorescence intensity decreased. Furthermore, the polymeric nanoparticle has a relatively high loading amount and encapsulation rate. Therefore, the polymeric nanoparticle would be a promising third-generation photosensitizer (PS) for PDT.
The Little Adsorption Book: A Practical Guide for Engineers and Scientists (1996)

This unique approach to the basic concepts of adsorption is written for students, engineers, scientists, and others who need a clear presentation of adsorption processes. Unlike other texts on this subject, which are written for the specialist and rely heavily on advanced mathematics, this unique book helps you solve everyday problems in applications of adsorption, without complex mathematics or computers.The author, a recognized expert in the field, gives you a quick introduction to the underlying physics of absorption and explains how to apply adsorption to solve analytical and design problems. Rich with practical examples and enhanced by illustrations that support the text, this refreshingly straightforward presentation helps you cut through the complexities of adsorption to find fast answers to pressing real-world questions.
Colutellin A, an immunosuppressive peptide from Colletotrichum dematium (2008)

Colletotrichum dematium is an endophytic fungus recovered from a Pteromischum sp. growing in a tropical forest in Costa Rica. This fungus makes a novel peptide antimycotic, colutellin A, with a MIC of 3.6 microg ml(-1) (48 h) against Botrytis cinerea and Sclerotinia sclerotiorum. Collutellin A has a mass of 1127.7 Da and contains residues of Ile, Val, Ser, N-methyl-Val and beta-aminoisobutryic acid in nominal molar ratios of 3 : 2 : 1 : 1 : 1, respectively. Independent lines of evidence suggest that the peptide is cyclic and sequences of Val-Ile-Ser-Ile and Ile-Pro-Val have been deduced by MS/MS as well as Edman degradation methods. Colutellin A inhibited CD4(+) T-cell activation of interleukin 2 (IL-2) production with an IC(50) of 167.3+/-0.38 nM, whereas cyclosporin A in the same test yielded a value of 61.8 nM. Inhibition of IL-2 production by collutellin A at such a low concentration indicates the potential immunosuppressive activity of this compound. In repeated experiments, cyclosporin A at or above 8 microg ml(-1) exhibited high levels of cytotoxicity on human peripheral blood mononuclear cells, whereas collutellin A or DMSO (carrier) alone, after 24 and 48 h of culture, exhibited no toxicity. Because of these properties collutellin A has potential as a novel immunosuppressive drug.
Electro-transport studies of electrodeposited (Bi<sub>1−<i>x</i></sub>Sb<sub><i>x</i></sub>)<sub>2</sub>Te<sub>3</sub>nanowires (2007)

A wide range of (Bi1−xSbx)2Te3 thin films and nanowires were electrodeposited from acidic tartaric–nitric baths. Initially, (Bi1−xSbx)2Te3 thin films were electrodeposited on gold substrates to investigate the effect of the deposition potential and electrolyte composition on film composition. After these investigations, (Bi1−xSbx)2Te3 nanowires were potentiostatically electrodeposited using polycarbonate templates as scaffolds. The deposition conditions strongly influenced the deposit composition, crystal structures, and electrical properties of the nanowires. The preferential crystal orientation of the nanowires shifted from a {110} orientation at −20 mV to a {015} orientation at −100 mV. The temperature dependent I–V characteristics of bundle nanowires indicated that the nanowires were semiconductors with negative temperature coefficient of resistivity. The thermal activation energies were 0.20 eV for Bi1.8Sb0.1Te3.1 and 0.49 eV for (Bi0.3Sb0.7)2Te3 nanowires, respectively.