gebhart/patrepeval huggingface dataset:
In Vivo Induction of Myeloid Suppressor Cells and CD4<sup>+</sup>Foxp3<sup>+</sup>T Regulatory Cells Prolongs Skin Allograft Survival in Mice (2010)

Natural CD4(+)Foxp3(+) T regulatory (Treg) cells can promote transplantation acceptance across major histocompatibility complex (MHC) barriers, while myeloid-derived suppressor cells (MDSCs) inhibit effector T-cell responses in tumor-bearing mice. One outstanding issue is whether combining the potent suppressive function of MDSCs with that of Treg cells might synergistically favor graft tolerance. In the present study, we evaluated the therapeutic potential of MDSCs and natural Treg cells in promoting allograft tolerance in mice by utilizing immunomodulatory agents to expand these cells in vivo. Upon administration of recombinant human granulocyte-colony stimulating factor (G-CSF; Neupogen), or interleukin-2 complex (IL-2C), Gr-1(+)CD11b(+) MDSCs or CD4(+)Foxp3(+) Treg cells were respectively induced at a high frequency in the peripheral lymphoid compartments of treated mice. Interestingly, induced MDSCs exhibited a more potent suppressive function in vitro when compared to MDSCs from naive mice. Furthermore, in vivo coadministration of Neupogen and IL-2C induced MDSCs at percentages that were higher than those seen when either agent was administered alone, suggesting an additive effect of the two drugs. Although treatment with either IL-2C or Neupogen led to a significant delay of MHC class II disparate allogeneic donor skin rejection, the combinatorial treatment was superior to either alone. Importantly, histological assessment of surviving grafts revealed intact morphology and minimal infiltrates at 60 days posttransplant. Collectively, our findings demonstrate that concurrent induction of MDSCs and Tregs is efficacious in downmodulating alloreactive T-cell responses in a synergistic manner and highlight the therapeutic potential of these naturally occurring suppressive leukocytes to promote transplantation tolerance.
The Traditional Medicine <i>Spilanthes acmella</i>, and the Alkylamides Spilanthol and Undeca‐2<i>E</i>‐ene‐8,10‐diynoic Acid Isobutylamide, Demonstrate <i>In Vitro</i> and <i>In Vivo</i> Antimalarial Activity (2011)

Spilanthes spp. are used as traditional herbal medicines in Africa and India to treat malaria. Yet, to date, there are no data on the active constituents or the most effective extraction methods for this indication. The isolated alkylamides, spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, found in S. acmella Murr., were shown to have IC₅₀s of 16.5 μg/mL and 41.4 μg/mL on Plasmodium falciparum strain PFB and IC₅₀s of 5.8 μg/mL and 16.3 μg/mL for the chloroquine resistant P. falciparum K1 strain, respectively. Further investigations revealed that at relatively low concentrations, spilanthol and the water extract of S. acmella reduced the parasitemia 59% and 53% in mice infected with P. yoelii yoelii 17XNL at 5 mg/kg and 50 mg/kg, respectively. Unexpectedly, the 95% ethanol extract of S. acmella was less effective (36% reduction in parasitemia) at 50 mg/kg. These results provide the first evidence supporting S. acmella against malaria and demonstrating active constituents in S. acmella against P. falciparum.
cat‐ELCCA: A Robust Method To Monitor the Fatty Acid Acyltransferase Activity of Ghrelin <i>O</i>‐Acyltransferase (GOAT) (2010)

Assays armed with catalytic signal amplification have arisen as superior systems for ultrasensitive detection of analytes. A conceptually new enzyme assay called cat-ELCCA (catalytic assay using enzyme-linked click-chemistry) is described, in which an enzyme-linked azide is utilized to arm the assay with catalytic fluorescence signal amplification. By using this assay technology, the first high-throughput screen for recently disclosed ghrelin O-acyltransferase (GOAT) was developed. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Statistical Plasma Physics, Volume I: Basic Principles (1992)

Plasma physics is an integral part of statistical physics, complete with its own basic theories. Designed as a two-volume set, Statistical Plasma Physics is intended for advanced undergraduate and beginning graduate courses on plasma and statistical physics, and as such, its presentation is self-contained and should be read without difficulty by those with backgrounds in classical mechanics, electricity and magnetism, quantum mechanics, and statistics. Major topics include: plasma phenomena in nature, kinetic equations, plasmas and dielectric media, electromagnetic properties of Vlasov plasmas in thermodynamic equilibria, transient processes, and instabilities.
Flexibility and Efficiency Enhancements for Constrained Global Design Optimization with Kriging Approximations (2002)

This dissertation examines methods that use kriging approximations to solve constrained nonlinear design optimization problems where the function evaluations are computationally expensive. The expense of the functions creates unique challenges for global optimization. Utilizing genetic algorithms or simulated annealing is impractical due to the large number of function evaluations required to reach convergence. Design problems involving computer simulations often yield noisy and/or discontinuous responses, which causes difficulty for gradient-based algorithms. One class of algorithms, referred to as Bayesian analysis algorithms, has shown promise at overcoming these difficulties. Bayesian analysis algorithms use global approximations of the functions to compute a statistics-based criterion for selecting the next iterate. By optimizing this inexpensive selection criterion over the entire design space, they retain global search properties without compromising local solution accuracy. The Efficient Global Optimization (EGO) algorithm of Jones, Schonlau and Welch is the Bayesian analysis algorithm that forms the basis of this work. It uses kriging models for approximations and the expected improvement function as the sampling criterion. The dissertation advances the state-of-the-art in Bayesian analysis in four ways: improving the abilities and accuracy of the global approximations, increasing the flexibility of the search strategy by incorporating a wide variety of sampling criteria, improving the ability to solve constrained problems, and increasing the efficiency and accuracy of the search by considering the computational burden of each response function. The version of the algorithm enhanced by the proposed changes is referred to as <italic>superEGO</italic> to signify that it can solve a <italic>superset</italic> of the problems EGO was originally designed to solve. Several examples are shown to demonstrate the benefits of these advancements. Incorporating available inexpensive information when searching for the next iterate reduced the number of iterations required to solve a simulation-based vehicle design problem by between 50% and 90%. In addition, the approximate models generated during an ergonomics experiment were shown to be three times more accurate using 25% fewer data samples when the sampling strategy was performed with superEGO using a criteria specifically designed for the study.
Theoretical and experimental considerations for a single-mode fiber-optic bend-type sensor (1997)

A novel single-mode bend fiber-optic sensing principle is presented. The design makes use of the translucent protective sheath that encases a typical fiber as a means of locating the position of a small bend present on an otherwise straight fiber. We can simultaneously determine bend magnitude by measuring the reduction in the fiber's core light. The theoretical model presented and the experimental results obtained are in excellent agreement, suggesting that a single-point sensor system is feasible with the proposed technique.
Significance of Mitochondrial Reactive Oxygen Species in the Generation of Oxidative Stress in Spermatozoa (2008)

We conclude that the sperm mitochondria make a significant contribution to the oxidative stress experienced by defective human spermatozoa.
A low-phase-noise and low-power multiband CMOS voltage-controlled oscillator (2005)

A low voltage multiband all-pMOS VCO was fabricated in a 0.18-/spl mu/m CMOS process. By using a combination of inductor and capacitor switching, four band (2.4, 2.5, 4.7, and 5 GHz) operation was realized using a single VCO. The VCO with an 1-V power supply has phase noises at 1-MHz offset from a 4.7-GHz carrier of -126 dBc/Hz and -134 dBc/Hz from a 2.4-GHz carrier. The VCO consumes 4.6 mW at 2.4 and 2.5 GHz, and 6 mW at 4.7 and 5 GHz, respectively. At 4.7 GHz, the VCO also achieves -80 dBc/Hz phase noise at 10-kHz offset with 2 mW power consumption.
Restoration of an image degraded by vibrations using only a single frame (2000)

A recently developed method for the restoration of motion- blurred images is investigated and implemented for the special compli- cated case of image blur due to sinusoidal vibrations. Sinusoidal vibra- tions are analyzed in the context of blur identification and image restoration. The extent of the blur and the optical transfer function (OTF) are identified from the blurred image by a straightforward process with- out the use of iterative techniques. The blurred image is restored using a simple Wiener filter with the identified OTF. The main novel achievement is the use of only a single vibrated blurred image as input information, on which the restoration process is based. The various cases of blur types that depend on the imaging conditions are considered. Examples of blur identification and image restoration are presented. © 2000 Society of Photo- Optical Instrumentation Engineers. (S0091-3286(00)01408-2)
Synthesis of 2-methyl-3-hydroxy-4H-pyran-4-one and 4-hydroxy-5-methyl-2H-furan-3-one from carbohydrates (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 2-methyl-3-hydroxy-4H-pyran-4-one and 4-hydroxy-5-methyl-2H-furan-3-one from carbohydratesTatsuya Shono, Yoshihiro Matsumura, Hiroshi Hamaguchi, and Shigeki NaitohCite this: J. Org. Chem. 1983, 48, 25, 5126–5128Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/jo00173a069https://doi.org/10.1021/jo00173a069research-articleACS PublicationsRequest reuse permissionsArticle Views335Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Isolation and analysis of the drug resistance of the flavobacterium and its production of beta-lactamases]. (2004)

Most of the flavobacteria in nosocomial infections were beta-lactamase-producing and were highly resistant to beta-lactamase antibiotics. Fluoroquinolones and beta-lactamase antibiotics with lactamase inhibitors should be the first choice for the management of infection caused by flavobacterium.
Panorama (1973)

Journal Article Panorama Get access Jo Ann V. Fowler Jo Ann V. Fowler Search for other works by this author on: Oxford Academic Google Scholar BioScience, Volume 23, Issue 3, March 1973, Pages 180–181, https://doi.org/10.1093/bioscience/23.3.180 Published: 01 March 1973
A new axial smoothing method based on elastic mapping (1996)

New positron emission tomography (PET) scanners have higher axial and in-plane spatial resolutions but at the expense of reduced per plane sensitivity, which prevents the higher resolution from being fully realized. Normally, Gaussian-weighted interplane axial smoothing is used to reduce noise. In this study, the authors developed a new algorithm that first elastically maps adjacent planes, and then the mapped images are smoothed axially to reduce the image noise level. Compared to those obtained by the conventional axial-directional smoothing method, the images by the new method have improved signal-to-noise ratio. To quantify the signal-to-noise improvement, both simulated and real cardiac PET images were studied. Various Hanning reconstruction filters with cutoff frequency=0.5, 0.7, 1.0/spl times/Nyquist frequency and Ramp filter were tested on simulated images. Effective in-plane resolution was measured by the effective global Gaussian resolution (EGGR) and noise reduction was evaluated by the cross-correlation coefficient. Results showed that the new method was robust to various noise levels and indicated larger noise reduction or better image feature preservation (i.e., smaller EGGR) than by the conventional method.
Comparison of EUV patterning performance between PTD and NTD for 1Xnm DRAM (2014)

Recently in the R&D area DRAM has shrunk to 1X nm, at the same time patterning technology has been one of the major challenges on 1X nm DRAM. Less than 20nm line and space and less than 30nm contact hole patterning are basically needed for 1X nm DRAM. Currently ArF immersion extension such as DPT (Double Patterning Technology), SADP (Self-Aligned Double Patterning) and SAQP (Self-Aligned Quadruple Patterning) shows robust patterning performance relative to EUV/DSA and become established process as a baseline for 1Xnm DRAM. But cost of ownership and process complexity of DPT/SADP can be the big burden for volume production. Furthermore too many DPT/SADP can make DRAM shrink meaningless. In spite of current issues on DPT/SADP, EUV source power has been the most critical issue so far. And now source power issue is pushing development of high sensitive EUV resist and related process. In this paper, author will compare EUV PTD and NTD in view of image contrast and swelling, also evaluate patterning performance between EUV PTD and NTD, and finally describe current status and issues of EUV NTD.
Ultrafast Folding of a Computationally Designed Trp-Cage Mutant:  Trp<sup>2</sup>-Cage (2005)

Miniproteins provide useful model systems for understanding the principles of protein folding and design. These proteins also serve as useful test cases for theories of protein folding, and their small size and ultrafast folding kinetics put them in a regime of size and time scales that is now becoming accessible to molecular dynamics simulations. Previous estimates have suggested the "speed limit" for folding is on the order of 1 mus. Here a computationally designed mutant of the 20-residue Trp-cage miniprotein, Trp2-cage, is presented. The Trp2-cage has greater stability than the parent and folds on the ultrafast time scale of 1 mICROs at room temperature, as determined from infrared temperature-jump experiments.
Effective Cooperation of Monoclonal Antibody and Peptide Vaccine for the Treatment of Mouse Melanoma (2012)

mAbs binding to tumor-associated surface Ags are therapeutically applied in a range of malignancies. Therapeutic vaccination only recently met with clinical success, and the first cancer vaccine received U.S. Food and Drug Administration approval last year. To improve current protocols, we combined peptide vaccines with mAb to the tyrosinase-related protein (TRP)-1 surface Ag for the treatment of B16F10 skin melanoma. Vaccine formulations with synthetic long peptides failed to elicit strong CD8 T cell responses to self-differentiation Ags gp100 and TRP-2, whereas altered peptide sequences recruited gp100-specific CD8 T cells from the endogenous repertoire with frequencies of 40%. However, these high frequencies were reached too late; large, progressively growing melanomas had already emerged. Addition of the TRP-1-directed mAb TA99 to the treatment protocol mediated eradication of s.c. lesions. The mode of action of the Ab did not depend on complement factor C3 and did not lead to improved Ag presentation and CD8 T cell immunity; rather, it recruited FcγR-bearing innate immune cells during early tumor control, thereby creating a window of time for the generation of protective cellular immunity. These data support the concept of combination therapy, in which passive transfer of mAbs is supplemented with cancer peptide vaccines. Moreover, we advocate that tumor Ag-specific T cell immunity directed against self-proteins can be exploited from the endogenous repertoire.
Orthogonal and Auto-Tandem Catalysis:  Synthesis of Dipyrido[1,2-<i>a</i>:2‘,3‘-<i>d</i>]imidazole and Its Benzo and Aza Analogues via Inter- and Intramolecular C−N Bond Formation (2005)

[reaction: see text] The synthesis of dipyrido[1,2-a:2',3'-d]imidazole and hitherto unknown benzo and aza analogues is described. These relatively complex polycyclic heterocycles could be smoothly prepared in one step from commercially available building blocks. Mechanistically, the developed procedure involves orthogonal (Pd and Cu catalyst) or auto-tandem (Pd catalyst) catalysis via regioselective inter- and intramolecular C-N bond formation.
Detent-Force Minimization of Double-Sided Interior Permanent-Magnet Flat Linear Brushless Motor (2015)

New detent-force minimization methodologies for a 6/4 double-sided interior permanent-magnet flat linear brushless motor configured with alternate teeth windings are presented in this paper. Based on the superposition principle, the end-effect and cogging forces are separately minimized using two different techniques. The end-effect force is reduced by a new 2-D optimization using the step-shaped end frames in the slotless stators. The cogging force is minimized through a destructive interference using the slot-phase shift between the upper and lower stators. Each technique is verified experimentally, and the optimal design parameters are formulated using Fourier series. The total detent-force reduction of 94% is achieved as compared with the base model. The steady-state force after applying these new detent-force-free techniques is demonstrated with actual measurements, and also compared with the finite-element analysis result and analytic solution.
Distribution of<i>Legionella</i>Species and Serogroups Isolated by Culture in Patients with Sporadic Community‐Acquired Legionellosis: An International Collaborative Survey (2002)

This international collaborative survey identified culture-confirmed legionellosis in 508 patients with sporadic community-acquired legionellosis. Legionella pneumophila constituted 91.5% of the isolates. Serogroup 1 was the predominant serogroup (84.2%), and serogroups 2-13 (7.4%) accounted for the remaining serogroups. The Legionella species most commonly isolated were L. longbeachae (3.9%) and L. bozemanii (2.4%), followed by L. micdadei, L. dumoffii, L. feeleii, L. wadsworthii, and L. anisa (2.2% combined). L. longbeachae constituted 30.4% of the community-acquired Legionella isolates in Australia and New Zealand.
High yields from course guides at Li Ka Shing Library (2011)

<a href="http://www.las.org.sg/sjlim/SJLIM2011YeoHighYields.pdf">http://www.las.org.sg/sjlim/SJLIM2011YeoHighYields.pdf</a>
Harnessing the Power of Passion in Optimizing Business Performance (2013)

No abstract is currently available.
Wearable tactile display based on soft actuator (2006)

Tactile sensation is one of the most important sensory functions for human perception of objects. Recently, there have been many technical challenges in the field of tactile sensing as well as tactile display. In this paper, we propose an innovative tactile display device based on soft actuator technology with electroactive polymer (EAP). This device offers advantageous features over existing devices with respect to intrinsic flexibility, softness, ease of fabrication and miniaturization, high power density, and cost effectiveness. In particular, it can be adapted to various geometric configurations because it possesses structural flexibility, so it can be worn on any part of the human body such as finger, palm, and arm etc. It can be extensively applied as a wearable tactile display, a Braille device for the visually disabled, and a human interface in the future. A new design of the flexible actuator is proposed and its basic operational principles are discussed. In addition, a tactile display device with 10times10 actuator array (100 actuator cells) is developed and its effectiveness is confirmed
Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes (2008)

The progression from insulin resistance to type 2 diabetes is caused by the failure of pancreatic beta cells to produce sufficient levels of insulin to meet the metabolic demand. Recent studies indicate that nutrient fluctuations and insulin resistance increase proinsulin synthesis in beta cells beyond the capacity for folding of nascent polypeptides within the endoplasmic reticulum (ER) lumen, thereby disrupting ER homeostasis and triggering the unfolded protein response (UPR). Chronic ER stress promotes apoptosis, at least in part through the UPR-induced transcription factor C/EBP homologous protein (CHOP). We assessed the effect of Chop deletion in multiple mouse models of type 2 diabetes and found that Chop-/- mice had improved glycemic control and expanded beta cell mass in all conditions analyzed. In both genetic and diet-induced models of insulin resistance, CHOP deficiency improved beta cell ultrastructure and promoted cell survival. In addition, we found that isolated islets from Chop-/- mice displayed increased expression of UPR and oxidative stress response genes and reduced levels of oxidative damage. These findings suggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress and apoptosis in beta cells under conditions of increased insulin demand.
« QUAND UNE FEMME ÉBRIÉ ACCOUCHE, ON LA TRAITE AVEC LES MÊMES SOINS JUSQU’AUJOURD’HUI, POUR QU’ELLE GROSSISSE ! » : ETUDE DE LA DIMENSION IDENTITAIRE DU « TAMBRUYA » À ABIDJAN (2012)

In Abidjan, the prevalence of metabolic syndrome is higher among women and people of Akan ethnic group. As is the case among people of Akan Lagoon, the appreciation of feminine curves explains the submission of nursing mothers of Ebrie ethnic in « Tambruya ». Despite the risk of overeating and oversleeping due to the appreciation of overweight, the role of this tradition has been neglected until now in the etiology of metabolic diseases. Semi-structured interviews with 10 nurses have brought about the meaning of « Tambruya » instead of overweight in relation to the canons of female beauty of Ebrie and perceptions of risk of these diseases. The research has demonstrated the legitimacy of « Tambruya » as a therapy and an expression means of ethnic identity Ebrie. Its has also shown the perception of the introduction of vitamin products in food and sorcery as causes of metabolic diseases.