gebhart/patrepeval huggingface dataset:
Multiwavelength optical content-addressable parallel processor for high-speed parallel relational database processing (1999)

We present a novel, to our knowledge, architecture for parallel database processing called the multiwavelength optical content-addressable parallel processor (MW-OCAPP). The MW-OCAPP is designed to provide efficient parallel data retrieval and processing by means of moving the bulk of database operations from electronics to optics. It combines a parallel model of computation with the many-degrees-of-processing freedom that light provides. The MW-OCAPP uses a polarization and wavelength-encoding scheme to achieve a high level of parallelism. Distinctive features of the proposed architecture include (1) the use of a multiwavelength encoding scheme to enhance processing parallelism, (2) multicomparand word-parallel bit-parallel equality and magnitude comparison with an execution time independent of the data size or the word size, (3) the implementation of a suite of 11 database primitives, and (4) multicomparand two-dimensional data processing. The MW-OCAPP architecture realizes 11 relational database primitives: difference, intersection, union, conditional selection, maximum, minimum, join, product, projection, division, and update. Most of these operations execute in constant time, independent of the data size. We outline the architectural concepts and motivation behind the MW-OCAPP's design and describe the architecture required for implementing the equality and intersection-difference processing cores. Additionally, a physical demonstration of the multiwavelength equality operation is presented, and a performance analysis of the proposed system is provided.
Optimal Design of Heatsink for 3 Phase Voltage Source Inverter System by Using Average Method (2010)

In this paper, to study the heat transfer characteristics of conduction, convection, radiation for heatsink, we considered the heat transfer characteristics of power electronics(IGBT). To confirm the power loss of power electronics, we analyzed relationship between the profile current ,varies according to the time and the average current of the profile. By this analysis, we proposed the heatsink model of optimization for temperature rise. Also, we varified that the temperature rise of heatsink is same in the profile current ,varies according to the time as well as in the average current of the profile. Furthermore, we resulted that the time response and heat resistor for heat sink is stable according to the heatsink's volume.
Improving Quantification of tabun, sarin, soman, cyclosarin, and sulfur mustard by focusing agents: A field portable gas chromatography-mass spectrometry study (2020)

Commercial gas chromatograph-mass spectrometers, one of which being Inficon's HAPSITE® ER, have demonstrated chemical detection and identification of nerve agents (G-series) and blistering agents (mustard gas) in the field; however most analyses relies on self-contained or external calibration that inherently drifts over time. We describe an analytical approach that uses target-based thermal desorption standards, called focusing agents, to accurately calculate concentrations of chemical warfare agents that are analyzed by gas chromatograph-mass spectrometry. Here, we provide relative response factors of focusing agents (2-chloroethyl ethyl sulfide, diisopropyl fluorophosphate, diethyl methylphosphonate, diethyl malonate, methyl salicylate, and dichlorvos) that are used to quantify concentrations of tabun, sarin, soman, cyclosarin and sulfur mustard loaded on thermal desorption tubes (Tenax® TA). Aging effects of focusing agents are evaluated by monitoring deviations in quantification as thermal desorption tubes age in storage at room temperature and relative humidity. The addition of focusing agents improves the quantification of tabun, sarin, soman, cyclosarin and sulfur mustard that is analyzed within the same day as well as a 14-day period. Among the six focusing agents studied here, diisopropyl fluorophosphate has the best performance for nerve agents (G-series) and blistering agents (mustard gas) compared to other focusing agents in this work and is recommended for field use for quantification. The use of focusing agent in the field leads to more accurate and reliable quantification of Tabun (GA), Sarin (GB), Soman (GD), Cyclosarin (GF) and Sulfur Mustard (HD) than the traditional internal standard. Future improvements on the detection of chemical, biological, radiological, nuclear, and explosive materials (CBRNE) can be safely demonstrated with standards calibrated for harmful agents.
Factors influencing the rate of preantral and antral growth of mouse ovarian follicles <i>in vitro</i> (1992)

The development of a culture system for individual mouse ovarian follicles using a low concentration of homologous serum, human follicle-stimulating hormone (hFSH) and a simple combination of growth factors is reported. Preantral follicles, 150 microns in diameter, with thecal cells attached were isolated mechanically. After 6-7 days on a Millicell membrane, a high proportion of the preantral follicles cultured individually with hFSH grew to morphologically normal large antral follicles (400-500 microns in diameter) with high oestradiol secretion. Without hFSH, the follicles grew to approximately 275 microns diameter in 6 days, but did not form antra or secrete oestradiol. The growth trajectory (overall pattern of growth formed by daily measurements of diameter) of each follicle was recorded and used as a measurement of response to experimental variation of culture conditions. The rapidly growing follicles were morphologically normal, but those that grew more slowly showed some abnormality or atresia and secreted less oestradiol. Follicles cultured in groups without being in direct contact with each other showed much poorer growth than those grown individually, but the inhibition was not uniform and some follicles grew larger than others in the group. Follicles that contacted each other directly in culture tended to fuse into one mass and their growth was substantially inhibited. Even under these conditions, one follicle often continued to grow slowly while the others degenerated. Such alteration of growth patterns suggests interfollicular paracrine control and may be a means of three-dimensional spacing of follicle growth within the ovary, as well as part of the mechanism of follicle selection. The dose-response curve based on the mean growth trajectory of follicles cultured individually, produced increasing rates of growth with 12.5-100 miu hFSH ml-1. Higher concentrations of hFSH did not increase growth rate further, but oestradiol secretion continued to increase with increasing hFSH up to the maximum used (2000 miu ml-1).
Biodegradable Nanofibrous Polymeric Substrates for Generating Elastic and Flexible Electronics (2014)

Biodegradable nanofibrous polymeric substrates are used to fabricate suturable, elastic, and flexible electronics and sensors. The fibrous microstructure of the substrate makes it permeable to gas and liquid and facilitates the patterning process. As a proof-of-principle, temperature and strain sensors are fabricated on this elastic substrate and tested in vitro. The proposed system can be implemented in the field of bioresorbable electronics and the emerging area of smart wound dressings.
An Examination of the Relative Merits of Various Sensors for Vehicle Navigation (1995)

The research described in this paper is aimed at
providing a quantitative measure and a qualitative
understanding of the contribution that each sensor in a
land-vehicle navigation system makes to the system’s
overall performance. This includes a quantitative
evaluation of the relative merits of various sensors
typically used in existing land-vehicle navigation
systems.
The results presented in this paper are based on data
obtained from analytical studies and simulations. An
analytical error model was derived for each sensor that
was examined. These error models were subsequently
used in a Kalman filter whose purpose was to generate an
estimate of the vehicle’s position. The Kalman filter was
used in several Monte Carlo simulation studies of various
system architectures. In addition, experimental data has
been obtained from a prototype navigation system that
has been installed in a test vehicle. These experimental
data have been used to verify the analytical error models
for several sensors.
Results show that the accurate calibration of a navigation
system’s heading and heading rate sensors to be of prime
importance. It has been found that a rate gyro’s scale
factor exhibits poor observability characteristics, and the
use of differential GPS fixes do not substantially improve
the estimate of this quantity. In addition, it has been
found that a rate gyro’s bias error contributes more to
positioning error than other rate gyro errors. Finally, we
have found that, in the absence of absolute position
measurements, the presence of a compass in the
navigation system plays a significant role in reducing
positioning errors.
SNR estimation of speech signals using subbands and fourth-order statistics (1999)

This article addresses the problem of instantaneous signal-to-noise ratio (SNR) estimation during speech activity for the purpose of improving the performance of speech enhancement algorithms. It is shown that the kurtosis of noisy speech may be used to individually estimate speech and noise energies when speech is divided into narrow bands. Based on this concept, a novel method is proposed to continuously estimate the SNR across the frequency bands without the need for a speech detector. The derivations are based on a sinusoidal model for speech and a Gaussian assumption about the noise. Experimental results using recorded speech and noise show that the model and the derivations are valid, though not entirely accurate across the whole spectrum; it is also found that many noise types encountered in mobile telephony are not far from Gaussianity as far as higher statistics are concerned, making this scheme quite effective.
Supercritical Carbon Dioxide Closed Brayton Cycle: Development and Applications. (2014)

Abstract not provided.
Development of Real-Time Traffic Adaptive Crash Reduction Measures for the Westbound I-94/35W Commons Section (2008)

Much research has been conducted in the development, implementation, and evaluation of innovative ITS technologies aiming to improve traffic operations and driving safety. An earlier project succeeded in supporting the hypothesis that certain traffic conditions are favorable to crashes and in developing real-time algorithms for the estimation of crash probability from detector measurements. Following this accomplishment a natural question is “how can this help prevent crashes?” This project has the ambitious plan of not only answering this question but also providing a multifaceted approach that can offer different types of solutions to an agency aimed at reducing crashes in this and other similar locations. This project has two major objectives; first it aimed at utilizing a cutting edge 3D virtual reality system to design and visualize different driver warning systems specifically for the I-94 westbound high crash location in Minneapolis, MN. Second, in view of the desire of local engineers for a more traditional approach, this project explored the use of existing micro-simulation models in the evaluation of safety improvements for the aforementioned high crash area. This report describes the results of these investigations but more importantly describes the lessons learned in the process of the research. These lessons are important because they highlight gaps of technology and knowledge that hampered this and other research projects with similar objectives.
An Improved Canny Edge Detection Algorithm Based on Type-2 Fuzzy Sets (2012)

Canny's edge detection algorithm is a classical and robust method for edge detection in gray-scale images. The two significant features of this method are introduction of NMS (Non-Maximum Suppression) and double thresholding of the gradient image. Due to poor illumination, the region boundaries in an image may become vague, creating uncertainties in the gradient image. In this paper, we have proposed an algorithm based on the concept of type-2 fuzzy sets to handle uncertainties that automatically selects the threshold values needed to segment the gradient image using classical Canny's edge detection algorithm. The results show that our algorithm works significantly well on different benchmark images as well as medical images (hand radiography images).
Novel flat datacenter network architecture based on scalable and flow-controlled optical switch system (2014)

We propose and demonstrate an optical flat datacenter network based on scalable optical switch system with optical flow control. Modular structure with distributed control results in port-count independent optical switch reconfiguration time. RF tone in-band labeling technique allowing parallel processing of the label bits ensures the low latency operation regardless of the switch port-count. Hardware flow control is conducted at optical level by re-using the label wavelength without occupying extra bandwidth, space, and network resources which further improves the performance of latency within a simple structure. Dynamic switching including multicasting operation is validated for a 4 x 4 system. Error free operation of 40 Gb/s data packets has been achieved with only 1 dB penalty. The system could handle an input load up to 0.5 providing a packet loss lower that 10(-5) and an average latency less that 500 ns when a buffer size of 16 packets is employed. Investigation on scalability also indicates that the proposed system could potentially scale up to large port count with limited power penalty.
Diffraction-limited imaging and beyond - the concept of super resolution‡ (2010)

It is well-known that experimental or numerical backpropagation of waves generated by a point-source/-scatterer will refocus on a diffraction-limited spot with a size not smaller than half the wavelength. More recently, however, super-resolution techniques have been introduced that apparently can overcome this fundamental physical limit. This paper provides a framework of understanding and analysing both diffraction-limited imaging as well as super resolution. The resolution analysis presented in the first part of this paper unifies the different ideas of backpropagation and resolution known from the literature and provides an improved platform to understand the cause of diffraction-limited imaging. It is demonstrated that the monochromatic resolution function consists of both causal and non-causal parts even for ideal acquisition geometries. This is caused by the inherent properties of backpropagation not including the evanescent field contributions. As a consequence, only a diffraction-limited focus can be obtained unless there are ideal acquisition surfaces and an infinite source-frequency band. In the literature various attempts have been made to obtain images resolved beyond the classical diffraction limit, e.g., super resolution. The main direction of research has been to exploit the evanescent field components. However, this approach is not practical in case of seismic imaging in general since the evanescent waves are so weak – because of attenuation, they are masked by the noise. Alternatively, improvement of the image resolution of point like targets beyond the diffraction limit can apparently be obtained employing concepts adapted from conventional statistical multiple signal classification (MUSIC). The basis of this approach is the decomposition of the measurements into two orthogonal domains: signal and noise (nil) spaces. On comparison with Kirchhoff prestack migration this technique is showed to give superior results for monochromatic data. However, in case of random noise the super- resolution power breaks down when employing monochromatic data and a limited acquisition aperture. For such cases it also seems that when the source-receiver lay out is less correlated, the use of a frequency band may restore the super-resolution capability of the method.
New disc-shaped triarylamino-1,3,5-triazines with heteroaromatic central cores (1996)

Abstract New disc-shaped triarylamino-1,3,5-triazines were prepared by reaction of cyanuric chloride with two-fold alkoxy substituted anilines. Each of the triarylmelamines exhibits an enanti-otropic mesophase. X-ray investigations reveal the formation of columnar liquid crystalline structures with either a hexagonal or a rectangular lattice. The lattice parameters, as well as the intracolumnar ordering, depend on the length of the flexible lateral side chains. The new melamines form Langmuir monolayers at the air/water interface due to their amphiphilic nature. The monolayer organization is characterized by a side-on arrangement of the molecules. The polar central molecular parts lie flat on the water, whereas the lateral alkyl chains are oriented perpendicular to the water surface.
Imaging Findings in Musculoskeletal Complications of AIDS (2004)

Patients with human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) are susceptible to a variety of complications that can affect the musculoskeletal system. These complications can be infectious, inflammatory, or neoplastic or can take some other form. Infection (cellulitis, necrotizing fasciitis, soft-tissue abscess, pyomyositis, osteomyelitis, septic arthritis) is the most common complication. Inflammatory processes include various arthritides as well as polymyositis. Non-Hodgkin lymphoma and Kaposi sarcoma are the two most common neoplasms in this patient population. Miscellaneous disorders include osteonecrosis, osteoporosis, rhabdomyolysis, anemia-related abnormal bone marrow, and hypertrophic osteoarthropathy. The underlying mechanisms leading to these diseases are complex and not fully understood but are thought to be multifactorial. Radiology may play an important role in early diagnosis and treatment planning in this population, in whom clinical and laboratory findings are commonly equivocal and nonspecific. Although biopsy is often necessary for the final diagnosis, it is important for the radiologist to be familiar with the different types of musculoskeletal disease in HIV-positive and AIDS patients so that an appropriate differential diagnosis can be established.
Antibody-powered nucleic acid release using a DNA-based nanomachine (2017)

A wide range of molecular devices with nanoscale dimensions have been recently designed to perform a variety of functions in response to specific molecular inputs. Only limited examples, however, utilize antibodies as regulatory inputs. In response to this, here we report the rational design of a modular DNA-based nanomachine that can reversibly load and release a molecular cargo on binding to a specific antibody. We show here that, by using three different antigens (including one relevant to HIV), it is possible to design different DNA nanomachines regulated by their targeting antibody in a rapid, versatile and highly specific manner. The antibody-powered DNA nanomachines we have developed here may thus be useful in applications like controlled drug-release, point-of-care diagnostics and in vivo imaging.
Application of a Combination of a Knowledge-Based Algorithm and 2-Stage Screening to Hypothesis-Free Genomic Data on Irinotecan-Treated Patients for Identification of a Candidate Single Nucleotide Polymorphism Related to an Adverse Effect (2014)

Interindividual variation in a drug response among patients is known to cause serious problems in medicine. Genomic information has been proposed as the basis for "personalized" health care. The genome-wide association study (GWAS) is a powerful technique for examining single nucleotide polymorphisms (SNPs) and their relationship with drug response variation; however, when using only GWAS, it often happens that no useful SNPs are identified due to multiple testing problems. Therefore, in a previous study, we proposed a combined method consisting of a knowledge-based algorithm, 2 stages of screening, and a permutation test for identifying SNPs. In the present study, we applied this method to a pharmacogenomics study where 109,365 SNPs were genotyped using Illumina Human-1 BeadChip in 168 cancer patients treated with irinotecan chemotherapy. We identified the SNP rs9351963 in potassium voltage-gated channel subfamily KQT member 5 (KCNQ5) as a candidate factor related to incidence of irinotecan-induced diarrhea. The p value for rs9351963 was 3.31×10-5 in Fisher's exact test and 0.0289 in the permutation test (when multiple testing problems were corrected). Additionally, rs9351963 was clearly superior to the clinical parameters and the model involving rs9351963 showed sensitivity of 77.8% and specificity of 57.6% in the evaluation by means of logistic regression. Recent studies showed that KCNQ4 and KCNQ5 genes encode members of the M channel expressed in gastrointestinal smooth muscle and suggested that these genes are associated with irritable bowel syndrome and similar peristalsis diseases. These results suggest that rs9351963 in KCNQ5 is a possible predictive factor of incidence of diarrhea in cancer patients treated with irinotecan chemotherapy and for selecting chemotherapy regimens, such as irinotecan alone or a combination of irinotecan with a KCNQ5 opener. Nonetheless, clinical importance of rs9351963 should be further elucidated.
The Type 7 Serotonin Receptor, 5-HT<sub>7</sub>, Is Essential in the Mammary Gland for Regulation of Mammary Epithelial Structure and Function (2015)

Autocrine-paracrine activity of serotonin (5-hydroxytryptamine, 5-HT) is a crucial homeostatic parameter in mammary gland development during lactation and involution. Published studies suggested that the 5-HT7 receptor type was important for mediating several effects of 5-HT in the mammary epithelium. Here, using 5-HT7 receptor-null (HT7KO) mice we attempt to understand the role of this receptor in mediating 5-HT actions within the mammary gland. We demonstrate for the first time that HT7KO dams are inefficient at sustaining their pups. Histologically, the HT7KO mammary epithelium shows a significant deviation from the normal secretory epithelium in morphological architecture, reduced secretory vesicles, and numerous multinucleated epithelial cells with atypically displaced nuclei, during lactation. Mammary epithelial cells in HT7KO dams also display an inability to transition from lactation to involution as normally seen by transition from a columnar to a squamous cell configuration, along with alveolar cell apoptosis and cell shedding. Our results show that 5-HT7 is required for multiple actions of 5-HT in the mammary glands including core functions that contribute to changes in cell shape and cell turnover, as well as specialized secretory functions. Understanding these actions may provide new interventions to improve lactation performance and treat diseases such as mastitis and breast cancer.