gebhart/patrepeval huggingface dataset:
Paired synovium and lymph nodes from rheumatoid arthritis patients differ in dendritic cell and chemokine expression (2004)

The aim of this study was to compare the cellular composition and organization of rheumatoid (RA) synovium, which has several of the characteristics of lymphoid organs, with lymph nodes. To clarify further whether RA synovium can be classified as an ectopic lymphoid organ, paired RA synovium and lymph node (LN) tissues from 11 patients were compared in terms of T-cell-B-cell and germinal centre (GC) organization, dendritic cell (DC) subsets, and chemokine expression. Tonsil, a normal secondary lymphoid organ, was used as a tissue control. In paired RA LN and synovium, more follicular DC-positive GCs were observed in LN, but when observed in synovium, they shared the same T-cell-B-cell organization and mean GC size. In LN, a predominance of mature DC-LAMP-positive DCs of myeloid (CD11c-positive) or lymphoid (CD123-positive) origin was observed, whereas paired RA synovium was characterized by the relative accumulation of immature CD1a-positive DCs. In the same way, CCL19-CCL21/CCR7, a chemokine/chemokine receptor complex involved in mature DC migration, was more frequently seen in LN than in paired RA synovium. In synovium, such expression was associated with lymphoid follicle formation, with or without a GC. Conversely, CCL20, a chemokine involved in immature DC migration, was expressed in RA synovium and tonsils but not in paired LNs. In conclusion, although similarities were observed, this study, using paired samples, indicates that the RA synovium lacks some of the features that are characteristic of a lymphoid organ.
Tissue Distribution and Developmental Expression of the Messenger RNA Encoding Angiogenin (1987)

New blood vessel growth occurs during normal fetal development and in diseases such as cancer and diabetes. The polypeptide angiogenin induces new blood vessel growth in two biological assays and may play a role in the vascular development of the fetus and in the neovascularization that accompanies diseases and wound healing. A complementary DNA probe for human angiogenin was used to examine the tissue distribution of angiogenin messenger RNA (mRNA) in the developing rat and in selected transformed cell lines. Angiogenin mRNA was detected predominantly in adult liver but was also detectable at low levels in other tissues. The expression of the angiogenin gene in rat liver was found to be developmentally regulated; mRNA levels were low in the developing fetus, increased in the neonate, and maximal in the adult. The amount of angiogenin mRNA in human HT-29 colon carcinoma and SK-HEP hepatoma cells was not greater than that in normal rat liver. These results demonstrate that angiogenin is predominantly expressed in adult liver, that the pattern of angiogenin gene expression is not temporally related to vascular development in the rat, and that the transformed cells studied do not contain more angiogenin mRNA than does normal liver. If angiogenin activity is controlled at the transcriptional level, the results of this study suggest that the primary function of angiogenin in vivo may be in processes other than the regulation of vascular growth.
Cystathionine β-synthase is essential for female reproductive function (2006)

In human reproduction, hyperhomocysteinemia has been reported as a risk factor for early pregnancy loss and congenital birth defects. Hyperhomocysteinemia is also recognized as a cause of maternal obstetric complications such as preeclampsia. The role of plasma hyperhomocysteinemia in female fertility was examined using cystathionine beta synthase knockout (cbs KO) mice. Cbs KO females were infertile, showed alterations in the estrus cycle and an increased progesterone response during pseudo-pregnancy induction. Both cbs KO ovaries and ovulated oocytes showed no major morphological alterations. However, placental and uterine masses were decreased at day 18 of pregnancy and showed morphological abnormalities. In cbs-KO pregnant females, the number of uterine implantation sites was not decreased despite the low number of surviving embryos. Fertility was restored when cbs-deficient ovaries were transplanted to normal ovarectomized recipients. We detected an increased uterine expression of Grp78, a marker of endoplasmic reticulum stress, which was accompanied by the decreased levels of uterine cbs mRNA in both hyperhomocysteinemic heterozygous (fertile) and homozygous (non-fertile) females. Our results indicate that cbs -/- female infertility is a consequence of the uterine failure and demonstrate that uterine endoplasmic reticulum stress and cbs expression are not determinant of infertility, suggesting that uterine dysfunction is a consequence of either hyperhomocysteinemia or other factor(s) in the uterine environment of cbs -/- animals. In summary, these studies demonstrate the potential importance of homocysteine levels for uterine handling of embryos.
Profile-assisted Compiler Support for Dynamic Predication in Diverge-Merge Processors (2007)

Dynamic predication has been proposed to reduce the branch misprediction penalty due to hard-to-predict branch instructions. A proposed dynamic predication architecture, the diverge-merge processor (DMP), provides large performance improvements by dynamically predicating a large set of complex control-flow graphs that result in branch mispredictions. DMP requires significant support from a profiling compiler to determine which branch instructions and control-flow structures can be dynamically predicated. However, previous work on dynamic predication did not extensively examine the tradeoffs involved in profiling and code generation for dynamic predication architectures. This paper describes compiler support for obtaining high performance in the diverge-merge processor. We describe new profile-driven algorithms and heuristics to select branch instructions that are suitable and profitable for dynamic predication. We also develop a new profile-based analytical cost-benefit model to estimate, at compile-time, the performance benefits of the dynamic predication of different types of control-flow structures including complex hammocks and loops. Our evaluations show that DMP can provide 20.4% average performance improvement over a conventional processor on SPEC integer benchmarks with our optimized compiler algorithms, whereas the average performance improvement of the best-performing alternative simple compiler algorithm is 4.5%. We also find that, with the proposed algorithms, DMP performance is not significantly affected by the differences in profile- and run-time input data sets
A Framework for Automatic Clustering of Parametric MIMO Channel Data Including Path Powers (2006)

We present a solution to the problem of identifying clusters from MIMO measurement data in a data window, with a minimum of user interaction. Conventionally, visual inspection has been used for the cluster identification. However this approach is impractical for a large amount of measurement data. Moreover, visual methods lack an accurate definition of a "cluster" itself. We introduce a framework that is able to cluster multi-path components (MPCs), decide on the number of clusters, and discard outliers. For clustering we use the K-means algorithm, which iteratively moves a number of cluster centroids through the data space to minimize the total difference between MPCs and their closest centroid. We significantly improve this algorithm by following changes: (i) as the distance metric we use the multi- path component distance (MCD), (ii) the distances are weighted by the powers of the MPCs. The implications of these changes result in a definition of a "cluster" itself that appeals to intuition. We assess the performance of the new algorithm by clustering real-world measurement data from an indoor big hall environment.
Increased expression of P/Q-type Ca2+ channel α1A subunit mRNA in cerebellum of N-type Ca2+ channel α1B subunit gene-deficient mice (2004)

The Ca(2+) channel alpha(1B) subunit is a pore-forming component capable of generating N-type Ca(2+) channel activity. Although the N-type Ca(2+) channel plays a role in a variety of neuronal functions, alpha(1B)-deficient mice show normal behavior, presumably owing to compensation by the other Ca(2+) channels. In this study, we examined the mRNA expression of the P/Q-type Ca(2+) channel alpha(1A) subunit in cerebellum of alpha(1B)-deficient mice. The alpha(1A) subunit mRNA in homozygous alpha(1B)-deficient mice was expressed at a significantly higher level than in wild or heterozygous mice. To examine whether the increased expression is induced by a cis-regulatory element within the 5'-upstream region of the alpha(1A) subunit gene, we examined lacZ expression in alpha(1B)-deficient x alpha(1A)3.0-lacZ mice (carrying a 3.0-kb 5'-upstream fragment of the alpha(1A) subunit gene fused to Escherichia coli lacZ reporter gene), which express lacZ in granule but not in Purkinje cells, and in alpha(1B)-deficient x alpha(1A)6.3-lacZ mice (carrying a 6.3-kb 5'-upstream region fused to lacZ gene), which express lacZ in Purkinje but not in granule cells. The levels of lacZ expression in homozygous alpha(1B)-deficient x alpha(1A)3.0-lacZ mice were significantly higher than in wild or heterozygous mice, but no difference in lacZ expression level was found among wild, heterozygous and homozygous alpha(1B)-deficient x alpha(1A)6.3-lacZ mice. Therefore, a possible explanation of the normal behavior of alpha(1B)-deficient mice is that compensation by alpha(1A) subunit gene occurs and that the 3.0-kb 5'-upstream region of alpha(1A) subunit gene contains an enhancer cis-element(s) for compensation in cerebellar granule cells.
Progestagen therapy for recurrent miscarriage (2007)

Standardized laboratory protocols for identifying potential targets of progestogen treatment as well as implementation of well-designed randomized studies are needed to establish the usefulness of progesterone supplementation in the treatment of RM.
Wind Turbine Generator Condition-Monitoring Using Temperature Trend Analysis (2011)

Condition monitoring can greatly reduce the maintenance cost for a wind turbine. In this paper, a new condition-monitoring method based on the nonlinear state estimate technique for a wind turbine generator is proposed. The technique is used to construct the normal behavior model of the electrical generator temperature. A new and improved memory matrix construction method is adopted to achieve better coverage of the generator's normal operational space. Generator incipient failure is indicated when the residuals between model estimates and the measured generator temperature become significant. Moving window averaging is used to detect statistically significant changes of the residual mean value and standard deviation in an effective manner; when these parameters exceed predefined thresholds, an incipient failure is flagged. Examples based on data from the Supervisory Control and Data Acquisition system at a wind farm located at Zhangjiakou in northern China have been used to validate the approach and examine its sensitivity to key factors that influence the performance of the approach. It is demonstrated that the technique can identify dangerous generator over temperature before damage has occurred that results in complete shutdown of the turbine.
Bis-Aliphatic Hydrazone-Linked Hydrogels Form Most Rapidly at Physiological pH: Identifying the Origin of Hydrogel Properties with Small Molecule Kinetic Studies (2014)

Rheological and small molecule kinetic studies were performed to study the formation and hydrolysis of the bis-aliphatic hydrazone bond. The rate of gelation was found to correspond closely with the rate of bond formation and the rate of gel relaxation with the rate of hydrolysis, indicating that small molecule kinetic studies can play an important role in material design. Furthermore, unlike aryl or acyl hydrazone bonds, the bis-aliphatic hydrazone bond forms rapidly under physiological conditions without requiring aniline catalysis yet maintains a pH-dependent rate of hydrolysis. These results suggest the bis-aliphatic hydrazone bond should find use alongside existing bioorthogonal click chemistries for bioconjugation, biomaterial synthesis, and controlled release applications.
Complex formation between catalysts, alcohols, and isocyanates in the preparation of urethanes (1967)

Abstract The mechanism of the catalyzed reaction between alcohols and isocyanates was investigated by means of NMR, infrared, and ultraviolet spectroscopy. The shift of the OH proton resonance in the NMR spectra indicated the existence of a 1 : 1 complex in the system dibutyltin dilaurate (DBTDL)–1‐methoxy‐2‐propanol. Complex formation was also observed when lead naphthenate or triethylamine (TEA) were substituted for the DBTDL. Mixtures of the DBTDL–TEA catalysts caused a shift of the OH proton resonance greater than that observed for either catalyst alone. This correlates with the synergistic effect noted when preparing urethanes with a mixture of these catalysts. No direct evidence of alcohol–catalyst complex formation could be obtained by infrared spectroscopy. Efforts were also made to detect complex formation in mixtures of phenyl isocyanate and catalysts. These complexes could not be detected by NMR, infrared, or ultraviolet spectroscopy.
Analytical bias among different gas chromatographic approaches using standard BTX gases and exhaust samples (2009)

In this study, the analytical compatibility of the gas chromatographic (GC) approach was evaluated through a cross-calibration exercise. To this end, three aromatic volatile organic compounds (VOCs: benzene, toluene, and p-xylene (BTX)) were simultaneously analyzed with four individual instrumental setups (type I = GC with MS plus solid phase microextraction (SPME) method, II = GC with flame ionization detection (FID) plus SPME, III = fast GC-FID plus SPME, and IV = GC-FID plus air server/thermal desorption (AS/TD) method). A comparison of basic quality assurance (QA) data revealed considerable differences in DL values among the methods with moderate variabilities in the intercompound sensitivity. In light of the differences in detection properties, the analytical bias involved for each methodological approach was assessed by the relative relationship between analytes and basic operating conditions. The results suggest that the analysis of environmental samples at ultra-low concentration levels (at or below ppb level) can be subject to diverse sources of bias. Although detection properties of target compounds seem to be affected by the combined effects of various factors, changes in the sample concentration levels were seen to be the most consistent under the experimental setups analyzed in this study.
3D Surface Related Multiple Elimination for Wide Azimuth Towed Streamer Seismic Data (2007)

B038 3D Surface Related Multiple Elimination for Wide Azimuth Towed Streamer Seismic Data K.H. Matson* (BP America) SUMMARY The application of 3D SRME to Wide Azimuth Towed Streamer Seismic data represents a step forward in terms of predicting complex 3D multiples compared to methods that use Narrow Azimuth Streamer data alone. We present synthetic and field data tests and discuss some of the data processing challenges. EAGE 69 th Conference & Exhibition — London UK 11 - 14 June 2007 Introduction The application of Surface Related Multiple Elimination (SRME) has provided significant added value to practical processing projects over the
Towards multi-finger haptic devices: A computer keyboard with adjustable force feedback (2011)

This paper addresses the design of a novel computer keyboard embedding 64 miniature actuators providing a programmable force feedback in response to human strokes. A specific electromechanical actuator is designed using a global methodology. Then, a parallel strategy is set to efficiently control all the actuators simultaneously. Finally, two prototypes are presented: the haptic pad and the haptic keyboard. In addition, a graphic interface allows the user to define his preferable force profile: whether he prefers tough or soft keys, smooth of rough sensation or even a buckling-spring like feeling.
Synthesis and Properties of Optically Active Polyaniline Carbon Nanotube Composites (2006)

The in-situ polymerization of aniline in the presence of multiwalled carbon nanotubes and (S)-(+)-10-camphorsulfonic acid provides a route to optically active composite materials. Their chiroptical properties suggest that polymers and composite materials adopt similar optical properties indicative of “compact coil” in DMSO and “extended coil” in m-cresol. The optical activity in composite materials is preserved, although somewhat reduced to that of the pure polymer, which is attributed to the polymer phase coating nanotubes. This polymer phase is responsible for the lower electrical resistance observed for composite materials.
Involvement of intramuscular interstitial cells in nitrergic inhibition in the mouse gastric antrum (2003)

Intracellular recordings were made from isolated bundles of the circular muscle layer of mouse gastric antrum and the responses evoked by stimulating intrinsic nerve fibres were examined. Transmural nerve stimulation evoked a fast inhibitory junction potential (fast-IJP) which was followed initially by a smaller amplitude long lasting inhibitory junction potential (slow-IJP) and a period of excitation. The excitatory component of the response was abolished by atropine, suggesting that it resulted from the release of acetylcholine and activation of muscarinic receptors. Fast-IJPs were selectively reduced in amplitude by apamin and slow-IJPs were abolished by N(omega)-nitro-L-arginine. Slow-IJPs were associated with a drop in membrane noise, suggesting that inhibition resulted from a reduced discharge of unitary potentials by intramuscular interstitial cells of Cajal (ICC(IM)). The chloride channel blocker, anthracene-9-carboxylic acid, reduced the discharge of membrane noise in a manner similar to that detected during the slow-IJP. When recordings were made from the antrum of W/W(V) mice, which lack ICC(IM), the cholinergic and nitrergic components were absent, with only fast-IJPs being detected. The observations suggest that neurally released nitric oxide selectively targets ICC(IM) causing a hyperpolarization by suppressing the discharge of unitary potentials.
Hemagglutinin mutations related to antigenic variation in H1 swine influenza viruses (1992)

The hemagglutinin (HA) of a recent swine influenza virus, A/Sw/IN/1726/88 (H1N1), was shown previously to have four antigenic sites, as determined from analysis of monoclonal antibody (MAb)-selected escape mutants. To define the HA mutations related to these antigenic sites, we cloned and sequenced the HA genes amplified by polymerase chain reaction of parent virus and MAb-selected escape mutants. The genetic data indicated the presence of four amino acid changes. After alignment with the three-dimensional structure of H3 HA, three changes were located on the distal tip of the HA, and the fourth was located within the loop on the HA. We then compared our antigenic sites, as defined by the changed amino acids, with the well-defined sites on the H1 HA of A/PR/8/34. The four amino acid residues corresponded with three antigenic sites on the HA of A/PR/8/34. This finding, in conjunction with our previous antigenic data, indicated that two of the four antigenic sites were overlapping. In addition, our previous studies indicated that one MAb-selected mutant and a recent, naturally occurring swine isolate reacted similarly with the MAb panel. However, their amino acid changes were different and also distant on the primary sequence but close topographically. This finding indicates that changes outside the antigenic site may also affect the site. A comparison of the HA amino acid sequences of early and recent swine isolates showed striking conservation of genetic sequences as well as of the antigenic sites. Thus, swine influenza viruses evolve more slowly than human viruses, possibly because they are not subjected to the same degree of immune selection.
Inhibition of glyceraldehyde-3-phosphate dehydrogenase by phosphorylated epoxides and .alpha.-Enones (1994)

Pentalenolactone and koningic acid are antibiotics known for their potent inhibition of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase. The reactive groups present in these antibiotics are, respectively, an epoxide and an alpha-enone, which form covalent bonds with an active-site cysteine residue of the enzyme. This information was used for the design of two series of glyceraldehyde 3-phosphate analogues with similar reactive groups that could function as potential irreversible inhibitors of glyceraldehyde-3-phosphate dehydrogenase. Inactivation kinetics, NMR analysis, protection experiments, and titration of free cysteine residues together indicate that the inhibitors bind to the active site of the enzyme and form a covalent bond with the active-site cysteine residue of the enzyme. Binding probably takes place at the inorganic phosphate site of the enzyme and may lead to a conformational change. Comparison of the reactivities of the inhibitors for the glycosomal enzyme from the protozoan parasite Trypanosoma brucei and the rabbit muscle enzyme revealed that some of them had a preference for the trypanosome enzyme. When their effect was measured on the multiplication of trypanosome in vitro cultures, one inhibitor appeared to exhibit an inhibitory effect at a concentration significantly lower than the trypanocidal drugs, pentamidin and (difluoromethyl)ornithine, that are routinely used in the treatment of African sleeping sickness.
Zur Kristallchemie ungeladener Phosphazen-Basen, I [1] Strukturen zweier Hydrate und eines Acetats von Tris(dimethylamino)methyliminophosphoran / Crystal Chemistry of Uncharged Phosphazene Bases, I [1] Structures of Two Hydrates and an Acetate of Tris(dimethylamino) methyliminophosphorane (1996)

Two hydrates and an acetate of the uncharged, very strong phosphazene base tris(dimethylamino)methyliminophosphorane, (Me 2 N) 3 P=NMe (for short Me-P 1 ), have been characterized by their crystal structures. A monohydrate, Me-P 1 · H 2 O , mp. 3°C, is monoclinic with space group P2 1 /n and Z = 4 formula units per unit cell of dimensions a = 8.585, b = 11.107, c = 13.083 Å, and β = 97.76° at -30°C. Another hydrate, Me-P1 · 1.75 H 2 O, mp. - 11°C. is triclinic with P1̅, Z = 4, a = 7.924, b = 11.768, c = 14.257 Å, α = 89.70°,β = 86.30°, and 7 = 86.54° at -100°C. An acetate, Me-P 1 · CH 3 COOH, mp. 88°C, is also triclinic with P1̅, Z = 2, a = 7.558, b = 8.193, c = 11.431 A, a = 93.60°, β = 96.52°, and γ = 92.12° at-100°C. In the hydrate Me-P 1 · H 2 O , a centrosymmetric dimer of the formula unit is formed by O-H···N hydrogen bonds arranged in a four-membered ring. In the hydrate Me-P 1 · 1.75 H 2 O , two rings of this kind are linked by additional water molecules into an infinite chain each. Both hydrate structures are those of molecular adducts, in spite of the great strength of the base. By contrast, the structure of the acetate Me-P 1 · CH 3 COOH is clearly ionic, with an ion pair being formed by a bifurcated (three-center) hydrogen bond N-H(···O) 2 from the protonated N atom of the base cation to both O atoms of one and the same acid anion.