gebhart/patrepeval huggingface dataset:
Distinctive Effects of CCR5, CCR2, and SDF1 Genetic Polymorphisms in AIDS Progression (1998)

The Genetics of Resistance to Infection by HIV-1 (GRIV) cohort represents 200 nonprogressor/slow-progressor (Slowprog) and 90 fast-progressor (Fastprog) HIV-1-infected patients. Using this unique assembly, we performed genetic studies on three recently discovered polymorphisms of CCR5, CCR2, and SDF1, which have been shown to slow the rate of disease progression. The increased prevalence of mutant alleles among Slowprogs from the GRIV cohort was significant for CCR5 (p < .0001) but not for CCR2 (p = .09) or SDF1 (p = . 12), emphasizing the predominant role of CCR5 as the major HIV-1 coreceptor. However, the prevalence of the CCR2 mutant allele (64I) was significantly increased among Slowprogs homozygous for wild-type CCR5 compared with Fastprogs (p = .04). The prevalence of double mutants SDF1-3'A/3'A genotypes was also increased among Slowprogs homozygous for wild-type CCR5 compared with Fastprogs (p = .05). The effects of the CCR2 and SDF1 mutations are overshadowed by the protective effects of the CCR5 deletion. Predictive biologic markers such as CD4 cell counts or viral load in the Slowprog population did not show significant differences between Slowprog groups with wild-type or mutant alleles for the three genes. Thus, our data suggest that the effects of these genes are exerted earlier in infection and no longer evident in the Slowprog of the GRIV cohort whose average duration of HIV infection is 12 years. We conclude that these genes, whose products serve as viral coreceptors or their ligands, may play a role early in infection and delay the onset of disease. However, among Slowprogs, whose duration of infection is >8 years, they are no longer influential for maintenance of their longterm nonprogression status. Other genetic determinants may be responsible for late protective effects.
Low bit-rate compression of omnidirectional images (2009)

Omnidirectional images represent a special type of images that are captured by vision sensors with a 360-degree field of view. This work targets the compression of such images by taking into account their particular geometry. We first map omnidirectional images to spherical ones and then perform sparse image decomposition over a dictionary of geometric atoms on the 2D sphere. A coder based on Matching Pursuit and adaptive quantization is finally proposed for efficient compression of omnidirectional images. The experiments demonstrate that the proposed system outperforms JPEG2000 coding of unfolded images. Since most omnidirectional sensors can be parametrized with a spherical camera model, the proposed method is generic with respect to different sensor constructions.
Primary Synchronization Signal Detection Method for Device-to-Device in LTE-Rel 12 and Beyond (2015)

Device-to-device (D2D) proximity services has been one of the key topics in Release 12 of 3GPP LTE and most of its technical specifications were recently concluded. Among them, synchronization procedure is a crucial step required for devices to proceed with any further operation such as discovery and communication. Once the devices are synchronized, other operations can be initiated. Technical details pertaining to synchronization procedure and its signal structure were finalized in the latest 3GPP meeting. In this paper, we address the implementation constraints and propose a detection method for primary synchronization signal (PSS) in D2D. D2D primary synchronization signals (D2DPSS) are primarily based on the synchronization signals in downlink, but with required modifications in terms of signal position, periodicity, power, etc. D2D signals are single-carrier frequency division multiplexed (SCFDM), transmitted at lower power from user equipment and hence the detection is much more difficult. Therefore, it becomes necessary to take these constraints into consideration and develop a robust detection method for PD2DSS. The proposed detection method referred to as selective summing of correlations provides the target performance while operating within constraints and requirements of D2D. In comparison to existing methods, this method reaches the target hit-rate at lower SNR values, while maintaining low false-alarm rate.
Adaptive control of the oxidation ditch reactors in a wastewater treatment plant (2012)

SUMMARY This paper describes the application of adaptive predictive expert (ADEX) control methodology to the oxidation ditch reactor in the wastewater treatment plant of Ceutí (Murcia, Spain) and evaluates the performance of the ADEX control system against that of the previous control system operating the plant. After a basic description of ADEX control methodology, the ditch reactor is described, as well as the control objectives and the control strategy, which focused on energy consumption reduction. The results of the application of the ADEX control system show significant improvement compared with the previous control system in terms of higher stability and precision of controlled variables, reduction of energy consumption of the plant, and better quality of the effluent water. Copyright © 2012 John Wiley & Sons, Ltd.
Natural Anamorphosis Process (2020)

Natural Anamorphosis Process’ non-invasive, non-forceful, non-dynamic natural way of approach, innocuousneutral behavior, omnidirectional-independent character (health-development oriented) and centrifugal-orbital tactic (detached from the origins of impediment, the roots of disorder and the sources of malfunction) has been applied to various cases such as: GMFCS level 5 cerebral palsy (CP), near death traumatic brain injury (TBI) with complete loss of vision-orthopedic deformities- schizophrenia and epileptic seizures history, congenital heart disease (CHD) with increased Cobb curvature angles measurement scoliosis and intellectual disability, chronic obstructive pulmonary disease (COPD), extended hepatic tissue deterioration- hepatic blood flow (HBF) decrease and steatosis from alcohol addiction, benign prostatic hyperplasia (BPH) with secondary lower urinary track symptoms (LUTS), blood cells and iron level irregularities, chronic back pain accompanied by sciatica due to vertebral column & intervertebral discs degeneration, femoral head avascular necrosis (AVN), extended squamous cells skin necrosis (undiagnosed or neglected Bowen’s disease?), Legg-Calve- Perthes disease, complex fractures, chronic fatigue, overuse syndromes, migraines, tinnitus, eyesvisual anomalies, oxidative stress and consequential irritation of the digestive track in generalfood intolerance symptoms, post- surgery subdural brain hematoma. N.A.P’s methodology has been also offered to the social services of the public sector as a parallel system of approach regarding autistic children and drug addicts.
A SYSTEMS APPROACH TO THE DEVELOPMENT OF AN INTEGRATED COLLISION AVOIDANCE VEHICLE (1995)

This article describes how systems engineering techniques are being used in the development of a crash avoidance demonstration vehicle that integrates existing vehicle features with new technologies and an understanding of driver needs.
Objective Estimation of Perceived Speech Quality Using Measuring Normalizing Blocks (1998)

Perceived speech quality is most directly measured by subjective listening tests. These tests are often slow and expensive, and numerous attempts have been made to supplement them with objective estimators of perceived speech quality. These attempts have found limited success, primarily in analog and higher–rate, error–free digital environments where speech waveforms are preserved or nearly preserved. How to objectively measure the perceived quality of highly compressed digital speech, possibly with bit errors or frame erasures, has remained an open question. We describe a new approach to this problem, using a simple but effective perceptual transformation, and a hierarchy of measuring normalizing blocks to compare perceptually transformed speech signals. The resulting estimates of perceived speech quality were correlated with the results of nine subjective listening tests. Together, these tests include 219 4–kHz bandwidth speech encoders/decoders, transmission systems, and reference conditions, with bit rates ranging from 2.4–64 kb/s. When compared with six other estimators, significant improvements were seen in many cases, particularly at lower bit rates, and when bit errors or frame erasures were present. These hierarchical structures of measuring normalizing blocks, or other structures of measuring normalizing blocks, may also address open issues in perceived audio quality estimation, layered speech or audio coding, automatic speech or speaker recognition, audio signal enhancement, and other areas.
Rhythmic Bilateral Movement Training Modulates Corticomotor Excitability and Enhances Upper Limb Motricity Poststroke: A Pilot Study (2004)

The recovery of coordinated motor function after stroke onset has been associated with the practice of upper limb movements that required the activation of homologous muscles. This pilot study investigated whether repetitive bimanual coordinated movements enhanced upper limb corticomotor (CM) excitability and motor function poststroke. Patients practiced driving their paretic wrist through passive rhythmical flexion-extension by active flexion-extension of their unaffected wrist using purpose-built manipulanda over a 4-week period. Both preintervention and postintervention motricity was assessed using the upper limb Fugl-Meyer rating scale, and cortical maps of wrist flexor and extensor representations were derived from potentials evoked by transcranial magnetic stimulation. Five of nine subjects improved upper limb motricity in response to this novel active-passive bimanual movement therapy (APBT). Unaffected cortical map volume decreased, especially for a subgroup of five patients who had a postintervention increase in motricity. No change in unaffected map volume was revealed for the four patients who did not improve their postintervention motricity. No consistent shifts in cortical map center of gravity were revealed. These findings suggest that APBT can initiate an improvement in motricity that is accompanied by a balancing of between-hemisphere CM excitability. The findings justify the assessment of the rehabilitative effects of APBT in a homogeneous sample of patients poststroke.
The demiphone: an efficient subword unit for continuous speech recognition (1997)

In this paper we introduce the demiphone as a contextual phonetic unit for continuous speech recognition. A phone is divided into two parts: a left demiphone that accounts for the left side coarticulation and a right demiphone that copes with the right side context. This new unit discards the dependence between the effects of both side contexts, but provides a better training of the transition between phones. The demiphone can be seen as a heuristic clustering of states that allows a more smoothed training of hidden Markov models and additionally supplies a simple way to create unseen triphones. We report experimental evidence that demiphones outperform the usual combination of triphones, right-side and left-side biphones and monophones.
Azepinoindoles. I. Hexahydroazepino[4,5-b]indoles (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAzepinoindoles. I. Hexahydroazepino[4,5-b]indolesJackson B. Hester Jr., Andrew H. Tang, Hugh H. Keasling, and William VeldkampCite this: J. Med. Chem. 1968, 11, 1, 101–106Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://pubs.acs.org/doi/10.1021/jm00307a023https://doi.org/10.1021/jm00307a023research-articleACS PublicationsRequest reuse permissionsArticle Views298Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Application of Artificial Immune System in Structural Health Monitoring (2014)

A large number of methods have been proposed in the area of structural health monitoring (SHM). However, many of them rely on the prior knowledge of structural-parameter-values or the assumption that the structural-parameter-values do not change without damage. This dependence on specific parameter values limits these methods’ applicability. This paper proposes an artificial immune system- (AIS-) based approach for the civil structural health monitoring, which does not require specific parameter values to work. A linear three-floor structure model and a number of single-damage scenarios were used to evaluate the proposed method’s performance. The high success rate showed this approach’s great potential for the SHM tasks. This approach has merits of less dependence on the structural-parameter-values and low demand on the training conditions.
Myelodysplastic syndrome with isolated deletion of chromosome 20q: an indolent disease with minimal morphological dysplasia and frequent thrombocytopenic presentation (2007)

The present study analysed the clinicopathological features of nine myelodysplastic syndrome (MDS) patients in which del(20q) was the sole cytogenetic abnormality and a control group of 17 adult patients with idiopathic thrombocytopenic purpura (ITP). Seven of nine del(20q) patients were thrombocytopenic and six of nine were mildly anaemic at presentation. There was no significant morphological dysplasia identified in the del(20q) group as compared with the ITP group. These results indicate that MDS with del(20q) commonly presents with thrombocytopenia and has minimal morphological dysplasia. Cytogenetic analysis on adult patients undergoing bone marrow sampling for thrombocytopenia may help avoid misdiagnosis of MDS with del(20q) as ITP.
Staining of the Lens Capsule for Circular Continuous Capsulorrhexis in Eyes With White Cataract (1998)

We have developed a technique of staining the anterior capsule with a solution of indocyanine green that facilitates performance of the circular continuous capsulorrhexis in eyes with a mature cataract. We compared the results of phacoemulsification and intraocular lens implantation in 10 eyes with the capsule stained with results of 10 eyes having the same procedure with standard circular continuous capsulorrhexis. The results of specular microscopy and laser flare-cell photometry showed no statistically significant differences between the 2 groups. Although the safety of intraocular indocyanine green dye has not yet been definitively established, the findings of this pilot study suggest that it is safe and useful in visualizing the anterior capsule of a mature cataract during cataract surgery.
[Appropriate outcome measures for evaluating change in activities of daily living of elderly residents]. (2002)

FIM was found to be the most appropriate ADL measurement for evaluating changes in ADL of elderly residents. Regarding functional dimensions, locomotion in terms of transfer, walking and stairs was the most responsive. These findings indicate that the FIM functional dimension of locomotion is the most suitable for evaluating changes in ADL of elderly residents.
Sexually transmitted diseases of insects: distribution, evolution, ecology and host behaviour (2004)

Sexually transmitted diseases (STDs) of insects are known from the mites, nematodes, fungi, protists and viruses. In total 73 species of parasite and pathogen from approximately 182 species of host have been reported. Whereas nearly all vertebrate STDs are viruses or bacteria, the majority of insect STDs are multicellular ectoparasites, protistans or fungi. Insect STDs display a range of transmission modes, with 'pure' sexual transmission only described from ectoparasites, all of which are mites, fungi or nematodes, whereas the microparasitic endo-parasites tend to show vertical as well as sexual transmission. The distribution of STDs within taxa of insect hosts appears to be related to the life histories of the hosts. In particular, STDs will not be able to persist if host adult generations do not overlap unless they are also transmitted by some alternative route. This explains the observation that the Coleoptera seem to suffer from more STDs than other insect orders, since they tend to diapause as adults and are therefore more likely to have overlapping generations of adults in temperate regions. STDs of insects are often highly pathogenic, and are frequently responsible for sterilizing their hosts, a feature which is also found in mammalian STDs. This, combined with high prevalences indicates that STDs can be important in the evolution and ecology of their hosts. Although attempts to demonstrate mate choice for uninfected partners have so far failed it is likely that STDs have other effects on host mating behaviour, and there is evidence from a few systems that they might manipulate their hosts to cause them to mate more frequently. STDs may also play a part in sexual conflict, with males in some systems possibly gaining a selective advantage from transmitting certain STDs to females. STDs may well be important factors in host population dynamics, and some have the potential to be useful biological control agents, but empirical studies on these subjects are lacking.
Fermentation of Cucumbers Without Sodium Chloride (1995)

ABSTRACT Cucumbers were successfully fermented and stored in the absence of sodium chloride (salt) under laboratory conditions, provided the fruit were blanched (3 min, 77°C) before brining in a calcium acetate buffer and the brine inoculated with Lactobacillus planturum . Bloater formation was prevented by blanching even when brines were not purged of CO 2 . Firmness of cucumbers was similar in salt‐free brines or those containing salt after 1 mo, but firmness of salt‐free cucumbers was lower after storage for 12 mos. Under pilot‐scale, commercial conditions, however, the cucumbers were severely bloated, and the firmness was unacceptable after storage for 7 mo, due apparently to Microbial recontamination after blanching.
Genetic Mapping of Antibiotic Resistance in Markers <i>Bacillus subtilis</i> (1970)

Several antibiotic resistance markers in Bacillus subtilis have been mapped by three-factor transduction crosses using bacteriophage PBS1. These markers, which are thought to be located in genes coding for ribosomal proteins, are within a segment comprising about 5 per cent of the B. subtilis genetic map, close to the major group of rRNA cistrons. The order of genetic makers in this region was found to be cysA14 mic-1 dagger str-1 (ery-1, ole-2) spc-2 bry-2 lin-2. The positions of neo-2, nea-1, and kan-2 are uncertain, although they are located in this region to the right of cysA14.
Effects of Blood Collection Methods on Gelatin Zymography of Matrix Metalloproteinases (2003)

Matrix metalloproteinases (MMPs), zinc-dependent proteinases belonging to the family of matrixins, are involved in the processes of normal development and growth as well as in several pathologic states (1). MMP-2 (gelatinase A; EC 3.4.24.24) and MMP-9 (gelatinase B; EC 3.4.24.35) play crucial roles in the proteolytic cascade leading to extracellular matrix degradation (2). To evaluate the usefulness of MMPs as tumor markers, several authors have measured MMP-2 and MMP-9 in the blood of cancer patients, using serum or plasma samples, and reached contradictory conclusions (3)(4). The preanalytical steps of blood sampling and processing influence the concentrations of MMPs and their inhibitors (5)(6), but no data are available concerning the effect of blood specimen collection methods on the appearance of the full spectrum of MMP isoforms on gelatin zymograms.

We simultaneously collected blood samples from 20 healthy volunteers (median age, 36 years; range, 23–55 years) into plastic tubes with no additive, plastic tubes with a silica gel-coated surface as coagulation accelerator, lithium heparin-coated …
Lysosome and phagosome stability in lethal cell injury. Morphologic tracer studies in cell injury due to inhibition of energy metabolism, immune cytolysis and photosensitization. (1972)

In two types of cell injury in a tissue culture system, the possibility was tested that lysosome rupture may be a lethal cellular reaction to injury, and thus an important general cause of irreversibility of damage in injured tissue. Prior labeling of secondary lysosomes with the fluorochrome acridine orange, or with ferritin, was used to trace changes in lysosomes after applying an injury. The metabolic inhibitors iodoacetate and cyanide were used together to block the cell's energy supply, or attachment of antiserum and subsequent complement attack were used to damage the surface membrane, producing rapid loss of cell volume control. Living cells were studied by time-lapse phase-contrast cinemicrography and fluorescence microscopy, and samples were fixed at intervals for electron microscopy. The cytolytic action of complement was lethal to sensitized cells within 2 hours, but results showed that lysosomes did not rupture for approximately 4 hours and in fact did not release the fluorescent dye until after reaching the postmortem necrotic phase of injury. Cells treated with metabolic inhibitors also showed irreversible alterations, while lysosomes remained intact and retained the ferritin marker. The fluorochrome marker, acridine orange, escaped from lysosomes early after metabolic injury, but the significance of this observation is not clear. The results are interpreted as evidence against the concept that lysosome rupture threatens the survival of injured cells. The original suicide bag mechanism of cell damage thus is apparently not operative in the systems studied. Lysosomes appear to be relatively stable organelles which, following injury of the types studied, burst only after cell death, acting then as scavengers which help to clear cellular debris.
Morphing and Repairing a 3D Scalp Geometry in Building Hair Models and Simulation (2009)

An important phase in building a hair material simulation system is model construction. Because building the material model effects to simulation quality, model reality and storage space,.. besides, after the hair material model is built, we need to simulate the material model so that it has to guarantee about quality, model control ability. The article proposes a number of the hair material model technique based on the 3D morphing interpolation combined with the 3D scalp geometry repair technique (pushpin technique and surface relaxation technique), on the built model basis we propose the hair material simulation technique based on updating control points on the model, to build the hair material model so as to guarantee quality, to repair disorder hairs and solve deformation in interpolation and simulation process.