gebhart/patrepeval huggingface dataset:
The PILATUS 1M detector (2006)

The PILATUS 1M detector is a hybrid pixel array detector with over one million pixels that operate in single photon counting mode. The detector, designed for macromolecular crystallography, is the largest pixel array detector currently in use at a synchrotron. It is a modular system consisting of 18 multichip modules covering an area of 21 cm x 24 cm. The design of the components as well as the manufacturing of the detector including the bump-bonding was performed at the Paul Scherrer Institute (PSI). The use of a single photon counting detector for protein crystallography requires detailed studies of the charge collection properties of the silicon sensor. The 18 modules are read out in parallel, leading to a full frame readout-time of 6.7 ms. This allows crystallographic data to be acquired in fine-varphi-slicing mode with continuous rotation of the sample. The detector was tested in several experiments at the protein crystallography beamline X06SA at the Swiss Light Source at PSI. Data were collected both in conventional oscillation mode using the shutter, as well as in a fine-varphi-slicing mode. After applying all the necessary corrections to data from a thaumatin crystal, the processing of the conventional data led to satisfactory merging R-factors of the order of 8.5%. This allows, for the first time, determination of a refined electron density map of a macromolecular biological crystal using a silicon pixel detector.
Managerial Pay and Company Performance: UK Electrical and Office Equipment Goods Industry (1991)

It appears that the role of money as a motivator in work tasks has increased substantially during the past decade. This applies particularly to managerial and executive grades. First, why this might be the case is discussed. Second, the literature on the early research into the pay of the chief executive is reviewed, since a major point of consideration was the relationship between CEOs′ pay and firms′ performance. Third, the evidence on profit sharing and company performance is examined, as it appears that this form of linkage has increased in the last decade, particularly for managerial and executive grades. Fourth, a model for testing the relationship between managerial remuneration and the performance of the firm is presented. This model is then applied to internal and external measures of performance for a sample of 147 firms in the UK electrical and office equipment industry for the year 1987, and conclusions are drawn.
Complete nucleotide sequence of the genome of bovine leukemia virus: its evolutionary relationship to other retroviruses. (1985)

We report the complete 8714-nucleotide sequence of the integrated bovine leukemia virus genome and deduce the following genomic organization: 5' LTR-gag-pol-env-pXBL-3' LTR, where LTR represents a long terminal repeat and pXBL represents a region containing unidentified open reading frames. This genomic structure is similar to that of human T-cell leukemia virus. The LTR contains a putative splice donor site in the R region. The gag gene encodes a precursor protein with the form NH2-p15-p24-p12-COOH. The NH2- and COOH-terminal regions of the pol product show stronger homologies with those of avian, rather than murine, type C retrovirus, and its structure is identical to that of avian virus. The env gene encodes a surface glycoprotein (gp51) and a transmembrane protein (gp30). In contrast to the pol product, the gp30 shows stronger sequence homology with a murine, rather than avian homologue, indicating the chimeric nature of the bovine leukemia virus genome. Comparisons of the best conserved pol sequences and overall genomic organizations between several major oncoviruses allow us to propose that bovine leukemia and human T-cell leukemia viruses constitute a group, designated as type "E," of Oncovirinae.
Health Economics in Radiation Oncology: Introducing the ESTRO HERO project (2012)

New evidence based regimens and novel high precision technology have reinforced the important role of radiotherapy in the management of cancer. Current data estimate that more than 50% of all cancer patients would benefit from radiotherapy during the course of their disease. Within recent years, the radiotherapy community has become more than conscious of the ever-increasing necessity to come up with objective data to endorse the crucial role and position of radiation therapy within the rapidly changing global oncology landscape. In an era of ever expanding health care costs, proven safety and effectiveness is not sufficient anymore to obtain funding, objective data about cost and cost-effectiveness are nowadays additionally requested. It is in this context that ESTRO is launching the HERO-project (Health Economics in Radiation Oncology), with the overall aim to develop a knowledge base and a model for health economic evaluation of radiation treatments at the European level. To accomplish these objectives, the HERO project will address needs, accessibility, cost and cost-effectiveness of radiotherapy. The results will raise the profile of radiotherapy in the European cancer management context and help countries prioritizing radiotherapy as a highly cost-effective treatment strategy. This article describes the different steps and aims within the HERO-project, starting from evidence on the role of radiotherapy within the global oncology landscape and highlighting weaknesses that may undermine this position.
Power‐law conductivity in polythiophene/copper(<scp>II</scp>) acetylacetonate composites (2013)

Abstract This paper reports the charge transport mechanism of polythiophene ( PT ) matrix composites having various concentrations of copper( II ) acetylacetonate. Characterization and structural analyses of the samples were carried out via Fourier transform infrared spectroscopy, atomic absorption spectroscopy, differential scanning calorimetry, thermogravimetric analysis and scanning electron microscopy ( SEM ). The alternating current electrical properties were investigated as a function of temperature. The change of free energy of adsorption calculated from the Langmuir adsorption isotherm showed that metal ions were electrostatically adsorbed onto polymer chains. Significant morphological changes were observed from SEM images of PT depending on doping process which in turn affected the thermal degradation of PT . The charge transport mechanism determined from a power law showed that there was one frequency‐dependent conductivity region for PT , while there were two regions for the composites in contrast to studies reported in the literature. © 2013 Society of Chemical Industry
Coupling of Fermentation and Esterification: Microbial Esterification of Decanoic Acid with Ethanol Produced via Fermentation (2001)

Two different kinds of bioprocess, ethanol fermentation and subsequent microbial esterification, were coupled using Issatchenkia terricola IFO 0933 in an interface bioreactor. The strain produced ethyl decanoate (Et-DA) by esterification of exogenous decanoic acid (DA) with ethanol produced via fermentation. The efficiency of the new coupling system depended on the concentration of glucose in a carrier and DA in an organic phase (decane) in an agar plate interface bioreactor. Optimum glucose content and DA concentration were 4% and 29 mM, respectively.
Gene expression in Leishmania: analysis of essential 5' DNA sequences. (1992)

A major unanswered question in Kinetoplastida parasites is the mechanism of regulating gene expression. Using a transfection system, we have previously shown that the intergenic region of the alpha-tubulin gene of Leishmania enriettii contained sequences required for gene expression. The goal of the work reported here was to determine whether the Leishmania-derived sequences were providing transcriptional control signals or functioning at a post-transcriptional level, most likely in trans-splicing. The chloramphenicol acetyltransferase (cat) gene was used as the reporter gene and was stably introduced into L. enriettii as part of an extrachromosomal element by transfection. We show here that the production of cat mRNA was dramatically dependent on the presence of the intergenic region 5' to the cat gene. The intergenic region could be substituted by a smaller fragment (222 base pairs) that contained the trans-splice acceptor site and an adjacent polypyrimidine tract. This native fragment could be replaced by a synthetic polypyrimidine tract containing an AG site. The native and the synthetic fragments had unidirectional activity. No effect on transcription of the cat gene by the wild-type fragment or the synthetic polypyrimidine was detected. The results indicate that both regions contain signals that affect RNA stability, probably sequences involved in trans-splicing.
Supercontinuum Generation in Suspended Core As<sub>2</sub>S<sub>3</sub> Tapered Fiber (2020)

We report the first supercontinuum source using a tapered microstructured As <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> fiber by pumping at a wavelength of 1.938 μm. The all-fiber source leads to a supercontinuum spanning from 1.50 μm to 2.65 μm with an average power of 14.5 mW.
Personalized recommendation driven by information flow (2006)

We propose that the information access behavior of a group of people can be modeled as an information flow issue, in which people intentionally or unintentionally influence and inspire each other, thus creating an interest in retrieving or getting a specific kind of information or product. Information flow models how information is propagated in a social network. It can be a real social network where interactions between people reside; it can be, moreover, a virtual social network in that people only influence each other unintentionally, for instance, through collaborative filtering. We leverage users' access patterns to model information flow and generate effective personalized recommendations. First, an early adoption based information flow (EABIF) network describes the influential relationships between people. Second, based on the fact that adoption is typically category specific, we propose a topic-sensitive EABIF (TEABIF) network, in which access patterns are clustered with respect to the categories. Once an item has been accessed by early adopters, personalized recommendations are achieved by estimating whom the information will be propagated to with high probabilities. In our experiments with an online document recommendation system, the results demonstrate that the EABIF and the TEABIF can respectively achieve an improved (precision, recall) of (91.0%, 87.1%) and (108.5%, 112.8%) compared to traditional collaborative filtering, given an early adopter exists.
Electronic Authority Variation (2009)

When a person joins in an organization, he becomes authorize to take some decisions on behalf of that organization; means he is given some authority to exercise. After some time, on the basis of his performance in the organization, he is given promotion and he becomes eligible to exercise to some higher authorities. And further, he may get some higher promotion or he may leave the organization. So, during his stay in the organization, the authority of that person varies from the time he joins the organization until he/she leaves the organization. This paper presents the variation in authorities of a person in the organization. The method implements the queuing model to analyze the various people in the queue of their promotion and looks at various parameters like average waiting time etc.
New Progress on the Pharmacological and Pharmacokinetical Study of Ginsenoside Rg3 (2012)

More than 40 kinds of ginsenosides have already been isolated from white or red ginseng. Recent years, a great interest has been focused on the effects of a single ginsenoside, ginsenoside Rg3, which is a minor ginsenoside in panax ginseng and is reported showing various medicinal effects. Ginsenoside Rg3 is now one of the most popular research projects of the world, and it provides a good material to overcome cancer. According to the reports of literature, this article summarized the origin, characterization, pharmacological activities, metabolism and the pharmacokinetic studies of ginsenoside Rg3. The brief summary on the progress of the research will provide the basis for the further development and utilization.
Roll/yaw control of a flexible spacecraft using skewed bias momentumwheels (1985)

Roll/yaw attitude control of a bias momentum stabilized flexible spacecraft is presented. The roll/yaw normal controller with a nonminimum phase control logic is shown to be very insensitive to the structural mode uncertainty. However, if this controller is switched on at the termination of a thruster-controlled stationkeeping maneuver, it cannot provide sufficient nutation damping by itself to guarantee that the initial transients will remain within specifications. Consequently, a roll/yaw transition controller has been designed to meet the pointing requirements during the transition from the stationkeeping mode to the normal mode. The new transition controller design requires consideration of the solar array flexibility because a control logic, designed to stabilize the nutation mode neglecting the solar array flexibility, could destabilize the solar array flexible mode.
Amphotericin B Mimics: A Sterol-Based Ionophore (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmphotericin B Mimics: A Sterol-Based IonophoreEdmund Stadler, Petr Dedek, Keiji Yamashita, and Steven L. RegenCite this: J. Am. Chem. Soc. 1994, 116, 15, 6677–6682Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ja00094a024https://doi.org/10.1021/ja00094a024research-articleACS PublicationsRequest reuse permissionsArticle Views309Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Apoptosis in the corneal epithelium. (1996)

The normal epithelial surface consists mainly of viable cells, with only a small percentage of nonviable cells and apoptotic cells. The results suggest that nonviable epithelial cells are shed after terminal differentiation, whereas viable cells can be shed by classical apoptosis with the formation of blebs. Thus, there appears to be more than one mechanism for removal of cells from the corneal surface.
Structure and function of V-ATPases in endocytic and secretory organelles (1992)

Chromaffin granules and clathrin-coated vesicles are major sources for V-ATPases of mammalian cells. Studies of these organelles have helped us to understand the structure and function of the enzyme. It was shown that V-ATPases are composed of distinct catalytic and membrane sectors containing several subunits. The subunit stoichiometry was determined to be 3A, 3B, 1C, 1D, 1E, 6c (proteolipids), 1Ac115 and ?Ac39. Additional subunits are likely to be discovered. Resolution and reconstitution of the enzyme revealed that the catalytic and membrane sectors are interdependent for their partial activity. The catalytic sector has no ATPase activity when detached from the membrane sector, and the membrane sector when depleted of the catalytic sector does not conduct protons. The mechanistic significance of these properties is discussed.
Dietary supplementation with n‐3 polyunsaturated fatty acids and human platelet function: a review with particular emphasis on implications for cardiovascular disease (1989)

The low incidence of myocardial infarction in Greenland Eskimos may be due to their intake of marine food with a high content of n-3 polyunsaturated fatty acids (PUFAs). In Eskimos the platelet count is lowered, the platelet aggregation is inhibited, the bleeding time is prolonged and the ratio between proaggregatory thromboxanes and anti-aggregatory prostacyclins is decreased, when compared to age- and sex-matched Danes. In this review, studies evaluating the effect of a fish diet or fish-oil supplementation on human platelet function are summarized. Most studies have demonstrated that supplementation with n-3 PUFAs can cause inhibition of platelet behaviour. The optimal dose of n-3 PUFAs and the patient groups most likely to profit from supplementation need to be defined. The safety and the clinical effect of the supplementation should be investigated in long-term studies.
Drug-Induced Nephrotoxicity: Clinical Impact and Preclinical<i>in Vitro</i>Models (2014)

The kidney is a major target for drug-induced toxicity. Drug-induced nephrotoxicity remains a major problem in the clinical setting, where the use of nephrotoxic drugs is often unavoidable. This leads frequently to acute kidney injury, and current problems are discussed. One strategy to avoid such problems would be the development of drugs with decreased nephrotoxic potential. However, the prediction of nephrotoxicity during preclinical drug development is difficult and nephrotoxicity is typically detected only late. Also, the nephrotoxic potential of newly approved drugs is often underestimated. Regulatory approved or validated in vitro models for the prediction of nephrotoxicity are currently not available. Here, we will review current approaches on the development of such models. This includes a discussion of three-dimensional and microfluidic models and recently developed stem cell based approaches. Most in vitro models have been tested with a limited number of compounds and are of unclear predictivity. However, some studies have tested larger numbers of compounds and the predictivity of the respective in vitro model had been determined. The results showed that high predictivity can be obtained by using primary or stem cell derived human renal cells in combination with appropriate end points.
Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1<sup>G93A</sup>Mouse Model of Amyotrophic Lateral Sclerosis (2015)

Motor cortex layer V pyramidal neurons (LVPNs) regulate voluntary control of motor output and selectively degenerate (along with lower motor neurons) in amyotrophic lateral sclerosis. Using dye-filling and whole-cell patch clamping in brain slices, together with high-resolution spinning disk confocal z-stack mosaics, we characterized the earliest presymptomatic cortical LVPN morphologic and electrophysiological perturbations in hSOD1(G93A) (SOD1) mice to date. Apical dendritic regression occurred from postnatal day (P) 28, dendritic spine loss from P21, and increased EPSC frequency from P21 in SOD1 LVPNs. These findings demonstrate extensive early changes in motor cortex of the SOD1 mouse model, which thus recapitulates clinically relevant cortical pathophysiology more faithfully than previously thought.
Management update: Market intelligence to maximise profit (2012)

We live in an information age, but many pharmacy owners find themselves adrift in a sea of data, struggling to manage their business efficiently and effectively in order to make a profit.
Location of Sources of Evoked Scalp Potentials: Corrections for Skull and Scalp Thicknesses (1981)

The problem of locating the position of the source of evoked potentials from measurements on the surface of the scalp has been examined. It is shown that the position of the source in a head modeled by a sphere surrounded by two concentric shells of differing conductivities representing the skull and the scalp can be inferred from source localization calculations made on a homogeneous model.
Functional Electrostimulation of Paraplegics: Experimental Investigations and First Clinical Experience with an Implantable Stimulation Device (1984)

A method of functional electrostimulation with an implantable 16-channel device and direct nerve stimulation for mobilization of paraplegic patients is presented. The experimental investigations to develop suitable electrode and stimulation devices, to find out optimal pulse parameters, and to study nerve and muscle alterations during FES are presented and discussed. The first clinical application in two cases and the results after one year are demonstrated.
Microelectronic applications for RF sources and accelerators (2002)

Lithographic microfabrication techniques have been applied to the development of cathodes. In this paper, we limit the discussion of microfabricated cathodes to gated field-emitter arrays, ferroelectric and microminiature therm-ionic vacuum cathodes. These cathodes have made significant advancements in the last few years. They share in common the potential of being temporally and spatially modulated at high frequencies by low voltages with low input power requirements. These properties not only provide opportunities to improve rf power sources and accelerators, but also provide opportunities to make new commercial products.
Two Cysteines in Plant R2R3 MYB Domains Participate in REDOX-dependent DNA Binding (2004)

Plant R2R3 MYB domain proteins comprise one of the largest known families of transcription factors. Discrete evolutionary steps have shaped the plant-specific R2R3 MYB family from the broadly distributed R1R2R3 MYB proteins. R1R2R3 MYB domains have a single Cys residue (Cys-130) that needs to be reduced for DNA binding and transcriptional activity. In contrast, most R2R3 MYB domains contain two cysteines, Cys-49 and Cys-53, with Cys-53 at the equivalent position as Cys-130 in R1R2R3 MYB. Using the maize P1 regulator of flavonoid biosynthesis as a typical R2R3 MYB-domain protein, we investigated here the in vitro REDOX requirement for DNA binding by P1. We show that the C53S mutation requires reducing conditions for DNA-binding, whereas C53A binds DNA under oxidizing and reducing conditions. Neither mutation impairs the in vivo regulatory activity of P1. The C49S and C49A mutants bind DNA in vitro irrespective of the REDOX conditions. A C49I mutant, which simulates the MYB domain of c-MYB, binds DNA only under reducing conditions, and its binding is significantly affected by the C53S replacement. It is interesting that under non-reducing conditions, Cys-49 and Cys-53 form a disulfide bond that prevents the R2R3 MYB domain from binding DNA. Together, our results suggest that the evolutionary origin of Cys-49 within the plants has provided R2R3 MYB domains with a regulatory feature not present in animal MYB domains, highlighting fundamental structural and functional differences between similar DNA-binding domains from plants and animals.
EGF Induced RET Inhibitor Resistance in<i>CCDC6-RET</i>Lung Cancer Cells (2016)

EGF could trigger resistance to RET inhibition in CCDC6-RET lung cancer cells, and endothelial cells may confer resistance to RET inhibitors by EGF. E7080 and other RET inhibitors may provide therapeutic benefits in the treatment of RET-positive lung cancer patients.