gebhart/patrepeval huggingface dataset:
Ketoprofen-inhibited N-acetyltransferase activity and gene expression in human colon tumor cells. (2006)

The activation of ketoprofen, which inhibits the outgrowth of azoxymethane-induced aberrant crypt foci in the rat colon, on the inhibition of arylamine N-acetyltransferase (NAT) activity (N-acetylation of substrates), gene expression (mRNA NAT) and 2-aminofluorene (AF)-DNA adduct formation was studied in a human colon tumor (adenocarcinoma) cell line (colo 205). Cellular cytosols (9000 xg supernatant) and intact colon tumor cells were used. The NAT activity in colo 205 cells was inhibited by ketoprofen in a dose- and time -dependent manner in both examined systems. The data also indicated that ketoprofen decreased the apparent value of V(max) of NAT enzymes, being a competitive inhibitor of NAT enzymes. The AF-DNA adduct formation in colo 205 cells was also decreased by ketoprofen. Based on the results from PCR, it was shown that ketoprofen affected mRNA NAT expression in human colon colo 205 cells. The cells were stained with anti-NAT antibody, then analyzed by flow cytometry. The results showed that ketoprofen decreased the percentage of cells stained by anti-NAT. This report is the first to demonstrate that ketoprofen inhibits human colon tumor cell NAT activity, gene expression and DNA adduct formation.
La clinica de lo social (2002)

A traves de la revision historica del Trabajo Social, intentaremos abordar la �invencion� de los sujetos sobre los cuales recae la accion profesional para pensar luego como, desde la clinica actual, se construyen estos sujetos en la intervencion del Trabajo Social en el campo de la Salud Mental. 
De tal modo, proponemos analizar la problematica a partir de casos clinicos en tratamiento ambulatorio en el Hospital de Emergencias Psiquiatricas �Torcuato de Alvear
Epidermal stem cells are retained <i>in vivo</i> throughout skin aging (2008)

In healthy individuals, skin integrity is maintained by epidermal stem cells which self-renew and generate daughter cells that undergo terminal differentiation. It is currently unknown whether epidermal stem cells influence or are affected by skin aging. We therefore compared young and aged skin stem cell abundance, organization, and proliferation. We discovered that despite age-associated differences in epidermal proliferation, dermal thickness, follicle patterning, and immune cell abundance, epidermal stem cells were maintained at normal levels throughout life. These findings, coupled with observed dermal gene expression changes, suggest that epidermal stem cells themselves are intrinsically aging resistant and that local environmental or systemic factors modulate skin aging.
Safety and Lack of Negative Effects of Wearable Augmented-Reality Social Communication Aid for Children and Adults with Autism (2018)

There is a growing interest in the use of augmented reality (AR) to assist children and adults with autism spectrum disorders (ASD); however, little investigation has been conducted into the safety of AR devices, such as smartglasses. The objective of this report was to assess the safety and potential negative effects of the <i>Empowered Brain system</i>, a novel AR smartglasses-based social communication aid for people with ASD. The version of the Empowered Brain in this report utilized Google Glass (Google, Mountain View, CA, USA) as its hardware platform. A sequential series of 18 children and adults, aged 4.4 to 21.5 years (mean 12.2 years), with clinically diagnosed ASD of varying severity used the system. Users and caregivers were interviewed about the perceived negative effects and design concerns. Most users were able to wear and use the Empowered Brain (<i>n</i> = 16/18, 89%), with most of them reporting no negative effects (<i>n</i> = 14/16, 87.5%). Caregivers observed no negative effects in users (<i>n</i> = 16/16, 100%). Most users (77.8%) and caregivers (88.9%) had no design concerns. This report found no major negative effects in using an AR smartglasses-based social communication aid across a wide age and severity range of people with ASD. Further research is needed to explore longer-term effects of using AR smartglasses in this population.
A robust iterative algorithm for wireless MIMO array auto-calibration (2004)

An algorithm is presented for estimating complex transmit and receive array calibration gains in a MIMO communications system. Calibration values are computed from a series of distinct channel transfer function matrix estimates over a time-varying channel. The new method, called RIMM (robust iterative multiple-channel MUSIC), is an extension of a previous algorithm proposed by B. Friedlander and A.J. Weiss (see Proc. ICASSP, p.2681-4, 1988). Several significant weaknesses in the earlier algorithm are demonstrated, and robust solutions are presented. An auto-calibration experiment is presented using 2.43 GHz indoor channel probing data samples.
Evidence that replication fork components catalyze establishment of cohesion between sister chromatids (2001)

Accurate chromosome segregation requires that replicated sister chromatids are held together until anaphase, when their "cohesion" is dissolved, and they are pulled to opposite spindle poles by microtubules. Establishment of new cohesion between sister chromatids in the next cell cycle is coincident with replication fork passage. Emerging evidence suggests that this temporal coupling is not just a coincident timing of independent events, but rather that the establishment of cohesion is likely to involve the active participation of replication-related activities. These include PCNA, a processivity clamp for some DNA polymerases, Trf4/Pol final sigma (formerly Trf4/Pol kappa), a novel and essential DNA polymerase, and a modified Replication Factor C clamp--loader complex. Here we describe recent advances in how cohesion establishment is linked to replication, highlight important unanswered questions in this new field, and describe a "polymerase switch" model for how cohesion establishment is coupled to replication fork progression. Building the bridges between newly synthesized sister chromatids appears to be a fundamental but previously unrecognized function of the eukaryotic replication machinery.
Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer (2003)

Lung cancer, a disease related mostly to tobacco smoke exposure and a leading cause of cancer-related death in industrialized countries, is frequently associated with mutations in the p53 tumor suppressor gene. Genetic differences resulting in inter-individual variation in DNA repair capacity may in part account for susceptibility of a cell to genotoxic agents leading to somatic mutations, including p53 mutations, and eventual transformation of a normal cell into a malignant phenotype. The objective of this study is to investigate the relationship between the polymorphisms of two DNA repair genes, the nucleotide excision repair xeroderma pigmentosum group D (XPD) gene (codons 312 and 751) and the base excision repair X-ray repair cross-complementing group 1 (XRCC1) gene (codon 399), and p53 mutations among lung cancer patients. Lung tumors from 204 smokers with non-small cell lung cancer (NSCLC) were analyzed for mutations in exons 5-8 of the p53 gene and genotypes of XPD and XRCC1. p53 mutations were found in 20% (40/204) of the patients. Patients with the XPD codon 312 Asn allele were less likely to have p53 mutations (13.8%) than XPD 312 Asp/Asp (27.3%) [odds ratio (OR) 0.43, 95% confidence interval (CI) 0.20-0.89, P = 0.023]. No association was found between p53 mutations and either XPD Lys751Gln or XRCC1 Arg399Gln. However, the p53 mutation frequency increased with the increased number of the combined genotypes among XPD 312WT (Asp/Asp), XPD 751VT (Lys/Gln or Gln/Gln) or XRCC1 399VT (Arg/Gln or Gln/Gln) (P = 0.01, trend test). These results suggest that individuals who smoke and have the XPD codon 312 Asp/Asp genotype may be at a greater risk of p53 mutations, especially if combined with other polymorphisms that may result in deficient DNA repair.
Timely Lossless Source Coding for Randomly Arriving Symbols (2018)

We consider a real-time streaming source coding system in which an encoder observes a sequence of randomly arriving symbols from an i.i.d. source, and feeds binary codewords to a FIFO buffer that outputs one bit per time unit to a decoder. Each source symbol represents a status update by the source, and the timeliness of the system is quantified by the age of information (AoI), defined as the time difference between the present time and the generation time of the most up-to-date symbol at the output of the decoder. When the FIFO buffer is allowed to be empty, we propose an optimal prefix-free lossless coding scheme that minimizes the average peak age based on the analysis of discrete-time Geo/G/1 queue. For more practical scenarios in which a special codeword is reserved for indicating an empty buffer, we propose an encoding scheme that assigns a codeword to the empty buffer state based on an estimate of the buffer idle time.
Immunodiagnosis of infection with Schistosoma mansoni: enzyme-linked immunosorbent assay for detection of antibody to circulating antigen. (1978)

A circulating antigen, a negatively charged polysaccharide from the trematode Schistosoma mansoni, was noncovalently bound to the surface of poly(L-lysine)-coated wells in polystyrene trays, which were then used in a micro-enzyme-linked immunosorbent assay (ELISA) test. The method provides an immunodiagnostic test for schistosomiasis of exceptional sensitivity with a high degree of specificity. Comparison of Bell egg counts and ELISA titers revealed a good correlation (r congruent to 0.80) in young individuals with low to moderate worm burdens, but this relationship was less marked in older individuals or those with high egg counts.
Effect of light illumination and camera moving speed on soil image quality (2012)

Soil texture has an important influence on agriculture such as crop selection, movement of nutrient and water, soil electrical conductivity, and crop growth. Conventionally, soil texture has been determined in the laboratory using pipette and hydrometer methods requiring significant amount of time, labor, and cost. Recently, in-situ soil texture classification systems using optical diffuse reflectometry or mechanical resistance have been reported, especially for precision agriculture that needs more data than conventional agriculture. This paper is a part of overall research to develop an in-situ soil texture classification system using image processing. Issues investigated in this study were effects of sensor travel speed and light source and intensity on image quality. When travel speed of image sensor increased from 0 to 10 mm/s, travel distance and number of pixel were increased to 3.30 mm and 9.4, respectively. This travel distances were not negligible even at a speed of 2 mm/s (i.e., 0.66 mm and 1.4), and image degradation was significant. Tests for effects of illumination intensity showed that 7 to 11 Lux seemed a good condition minimizing shade and reflection. When soil water content increased, illumination intensity should be greater to compensate decrease in brightness. Results of the paper would be useful for construction, test, and application of the sensor.
Large-scale event detection using semi-hidden Markov models (2003)

We present a new approach to recognizing events in videos. We first detect and track moving objects in the scene. Based on the shape and motion properties of these objects, we infer probabilities of primitive events frame-by-frame by using Bayesian networks. Composite events, consisting of multiple primitive events, over extended periods of time are analyzed by using a hidden, semi-Markov finite state model. This results in more reliable event segmentation compared to the use of standard HMMs in noisy video sequences at the cost of some increase in computational complexity. We describe our approach to reducing this complexity. We demonstrate the effectiveness of our algorithm using both real-world and perturbed data.
Holographic currents and the non-steady-state photoelectromotive force in cubic photorefractive crystals (1992)

Alternative (nondiffraction) methods for the characterization of photorefractive crystals, namely, a stationary holographic current and non-steady-state photo-emf are considered. The sign of the dominating photocarriers, their average lifetimes and transport lengths, the characteristic time for hologram formation, and concentration of trapping centers were estimated for BSO and GaAs:Cr crystals. These novel techniques can be used for the characterization of centrosymmetric photoconductive crystals as well.
Fluvastatin in combination with other lipid-lowering agents. (1994)

Fluvastatin, a new synthetic inhibitor of HMGCoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, has been studied in several models to examine its effects when used in combination with other lipid-modifying agents such as derivatives of fibric acid (bezafibrate), resins (cholestyramine), and niacin. The combination of fluvastatin with bezafibrate has been studied in a double-blind trial involving patients with well-documented familial hypercholesterolaemia. Fluvastatin 40 mg/day, combined with either bezafibrate 400 mg/day or cholestyramine 8 g/day, resulted in reductions in levels of low-density lipoprotein cholesterol (LDL-C), these being indistinguishable between the groups; however, significantly greater increases in levels of high-density lipoprotein cholesterol (21.3%) and reductions in levels of triglycerides (25.1%) were seen with the fluvastatin-bezafibrate combination. No notable increases were seen in levels of serum creatine kinase, aspartate aminotransferase, or alanine aminotransferase, and no cases of myopathy were observed. In a study model that examined low-dose combinations of fluvastatin with cholestyramine, reductions in levels of LDL-C of 15.8% and 19.3% were seen with fluvastatin 10 mg and 20 mg, respectively. After an 8-week interval in which a daily dosage of cholestyramine 8 g was added, from baseline, reductions of 26.3% in the 10 mg fluvastatin-cholestyramine group and 31.2% in the 20 mg fluvastatin-cholestyramine group were observed, whereas the placebo-cholestyramine group displayed a reduction of 14.9%. Doubling the resin dosage to 16 g/day for the final 8 weeks of the study provided little additional benefit. Myotoxicity has been observed when lovastatin is coadministered with niacin, and so the combination of niacin with fluvastatin has also been studied to examine the possibility of this effect occurring. Patients were randomised to either fluvastatin 20 mg or placebo for 6 weeks, after which time open-label niacin was administered to all patients and titrated to a final dosage of 3 g/day. After 6 weeks, fluvastatin produced a 20.8% reduction in LDL-C levels from baseline. When combined with niacin, a 43.7% reduction was noted at the week 15 endpoint, against the 26.5% reduction seen with niacin monotherapy. The combination was well tolerated, with no reports of myopathy or of significant elevations in creatine kinase or liver transaminase levels. Combinations of fluvastatin with a variety of other agents have been shown to have significant effects on lipid profiles, with no evidence to date of clinically remarkable safety findings. Thus, the use of combination therapies may result in optimal management of patients with moderately severe hypercholesterolaemia and mixed dyslipidaemic profiles.
Municipal Solid Waste Used As Bioethanol Sources And Its Related Environmental Impacts (2008)

An investigation into the possibility of replacing the conventional biomass with biodegradable municipal solid waste, which provides an alternative solution for preventing the biodegradable fraction of municipal solid waste (BMSW) going into landfill required by EU Landfill Directives (1999/31/EC) was carried out. However, as every type of energy have some advantages as well as disadvantages. The use of BMSW as biomass sources for the production of bio-ethanol was investigated. The experimental results have shown that more than 90% of the cellulose from the waste can be converted to glucose which can be easily fermented to ethanol production. The potential impacts on related environmental issues, such as sustainable waste management, climate change, water issues, land use and biodiversity, are discussed. Sustainable waste management solutions are also discussed under different environmental, economic, and social scenarios.
Short‐term improvement of endothelial function in rituximab‐treated rheumatoid arthritis patients refractory to tumor necrosis factor α blocker therapy (2008)

Our study demonstrates an active effect of rituximab on endothelial function in RA patients refractory to TNFalpha blockers.
A mini‐review: Cell response to microscale, nanoscale, and hierarchical patterning of surface structure (2014)

Cellular behavior can be influenced by the chemical and physical surface characteristics of biomedical substrates. To understand the relationships between various topographical surface patterns and cellular activities, various types of pattern models have been developed and examined in a range of sizes (microscale, nanoscale, and hierarchical structures consisting of both) and shapes (pillar, hole, groove, grate, grid, and island). Here, we review fabrication methods for obtaining physically patterned microscale and nanoscale surfaces, and discuss the relationships between cellular responses and physically patterned surfaces, which could be applied to various biomedical scaffolds used in tissue engineering applications.
Cambio climático y el metabolismo urbano de las Megaurbes Latinoamericanas (2012)

La problemática climática y medioambiental se perfila cada vez más como un reto para las ciudades, especialmente para aquellas donde está dándose un rápido proceso de urbanización y crecimiento poblacional. El análisis de su estado de situación es mejor entendido a partir de estudios metabólicos de la entrada y salida de flujos de materiales y de energía. Este tipo de evaluaciones se han realizado para diversas ciudades y para distintos aspectos, pero en América Latina están prácticamente ausentes. Este trabajo abre con una presentación general sobre el estado de situación de las ciudades latinoamericanas y con una introducción a las evaluaciones metabólicas para ofrecer una primera aproximación integral comparativa de los flujos de entrada y salida de las megaurbes latinoamericanas, esto es, de la Ciudad de México, Sao Paulo, Río de Janeiro y Buenos Aires. Se presentan las principales características de los planes de acción frente al cambio climático para cerrar con un breve análisis comparativo entre las acciones de mitigación y las dinámicas metabólicas existentes. Se concluye con una reflexión y sugerencias en torno al futuro urbano, los retos venideros y las oportunidades posibles.
Experimental Optimization of a Free-to-Rotate Wing for Small UAS (2014)

This paper discusses an experimental investigation conducted to optimize a free-to-rotate wing for use on a small unmanned aircraft system (UAS). Although free-to-rotate wings have been used for decades on various small UAS and small manned aircraft, little is known about how to optimize these unusual wings for a specific application. The paper discusses some of the design rationale of the basic wing. In addition, three main parameters were selected for "optimization", wing camber, wing pivot location, and wing center of gravity (c.g.) location. A small apparatus was constructed to enable some simple experimental analysis of these parameters. A design-of-experiment series of tests were first conducted to discern which of the main optimization parameters were most likely to have the greatest impact on the outputs of interest, namely, some measure of "stability", some measure of the lift being generated at the neutral position, and how quickly the wing "recovers" from an upset. A second set of tests were conducted to develop a response-surface numerical representation of these outputs as functions of the three primary inputs. The response surface numerical representations are then used to develop an "optimum" within the trade space investigated. The results of the optimization are then tested experimentally to validate the predictions.\n\n\n\n\n
CcpN (YqzB), a novel regulator for CcpA‐independent catabolite repression of <i>Bacillus subtilis</i> gluconeogenic genes (2005)

In Bacillus subtilis, the NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase (GapB) and the phosphoenolpyruvate carboxykinase (PckA) enzymes are necessary for efficient gluconeogenesis from Krebs cycle intermediates. gapB and pckA transcription is repressed in the presence of glucose but not via CcpA, the major transcriptional regulator for catabolite repression in B. subtilis. A B. subtilis mini-Tn10 transposant library was screened for clones affected in catabolite repression of gapB. Inactivation of a previously unknown gene, yqzB (renamed ccpN for control catabolite protein of gluconeogenic genes), was found to relieve not only gapB but also pckA transcription from catabolite repression. Purified CcpN specifically bound to the gapB and pckA promoters. ccpN is co-transcribed constitutively with another unknown gene, yqfL. A yqfL deletion lowers the level of gapB and pckA transcription threefold under both glycolytic and gluconeogenic conditions and a ccpN deletion is epistatic over a yqfL deletion. YqfL is thus a positive regulator of the expression of gapB and pckA, the effect of which is not influenced by the metabolic regime of the cell but appears to be mediated by CcpN. ccpN has homologues in many Firmicutes, but not all, while yqfL homologues are widely distributed in Eubacteria and also present in some plants. In all analysed bacterial genomes, ccpN and yqfL are physically linked together or to putative gluconeogenic genes. CcpN thus orchestrates a novel CcpA-independent mechanism for catabolite repression of gluconeogenic genes highly conserved in Firmicutes and appears as a functional analogue of FruR in Enterobacteria. The physiological significance of the regulation mediated via the three B. subtilis global transcription regulators, CcpA, CggR and CcpN, is discussed.
Kinetic of CO$_2$ Reduction by Gliding Arc Plasma (2007)

Decomposition of carbon dioxide (CO $_2$ ) by gliding arc plasma was examined. The plasma device consisted of two triangular stainless steel plates. The gas entered through a nozzle tube from the upstream cylinder reactor and exit at a downstream of the reactor. The effect of total gas flow rates have been used to study the chemical process reaction in gliding plasma system. The model of active-chemical kinetic of CO $_2$ decomposition was developed to investigate the pathways of plasma reactions. Experimental results indicate the conversion of CO $_2$ reached 18% at the total gas flow rate of 1.5 × 10 $^{-5}$ m $^3$ s $^{-1}$ and produced CO and O $_2$ as the final products.
DockerPolicyModules: Mandatory Access Control for Docker containers (2015)

The wide adoption of Docker and the ability to retrieve images from different sources impose strict security constraints. Docker leverages Linux kernel security facilities, such as namespaces, cgroups and Mandatory Access Control, to guarantee an effective isolation of containers. In order to increase Docker security and flexibility, we propose an extension to the Dockerfile format to let image maintainers ship a specific SELinux policy for the processes that run in a Docker image, enhancing the security of containers.