gebhart/patrepeval huggingface dataset:
Mapping Ontologies into Cyc (2002)

The advent of Web services, and the Semantic Web described by domain ontologies, highlight the bottleneck to their growth: ontology mapping, merging, and integration. In this paper we present the process by which over the last 15 years several ontologies of varying complexity have been mapped or integrated with Cyc, a large commonsense knowledge base. These include SENSUS, FIPS 10-4, several large (300k-term) pharmaceutical thesauri, large portions of WordNet, MeSH/Snomed/UMLS, and the CIA World Factbook. This has to date required trained ontologists talking with subject matter experts. To break that bottleneck – to enable subject matter experts to directly map/merge/integrate their ontologies – we have been developing interactive clarification-dialog-based tools.
Metabolic products of microorganisms. 200. Isolation and characterization of niphithricins A, B, and elaiophylin, antibiotics produced by Streptomyces violaceoniger. (1981)

Fermentations of Streptomyces violaceoniger TU 905 produce the antifungal antibiotics niphithricins A, B, elaiophylin and nigericin. The niphithricins have been characterized as new macrolide antibiotics, and the previously unknown structure of elaiophylin was determined to be a macrodiolide. The niphithricins were biologically active against Gram-positive bacteria and fungi. The mode of action is attributed to an alteration of the membrane permeability.
A novel wireless interconnect technology using impulse radio for interchip communications (2006)

This paper presents a novel wireless interconnect technology using impulse radio for interchip communications. The performance analysis of a binary phase-shift-keying (BPSK) impulse radio shows that a high data rate of 2.5 Gb/s with a low bit error rate <10/sup -6/ over an interchip wireless channel of length 20 cm can be achieved with the radiated power spectral density less than -41 dBm/MHz. The hardware design of the BPSK ultra-wideband (UWB) impulse radio realizes transmitter and receiver integrated circuits in 0.18-/spl mu/m CMOS and antenna in a low-temperature cofired ceramic processes. Due to the current design and process limitations, the prototype impulse radio achieves a maximum data rate up to 200 Mb/s over the interchip wireless channel of length 20 cm with a total power consumption of 120 mW. The feasibility of using UWB impulse radio for Gb/s interchip wireless communication is addressed.
Predicting Outcome in Central Retinal Vein Occlusion Using the Flicker Electroretinogram (1993)

The 30-Hz flicker ERG provides useful information about the patients with central retinal vein occlusion.
Histone Deacetylase Inhibitors in Cancer Therapy (2003)

Histone deacetylase inhibitors (HDAC inhibitors) represent a novel class of antineoplastic agents that act by promoting acetylation of histones, leading in turn to uncoiling of chromatin and activation of a variety of genes implicated in the regulation of cell surivival, proliferation, differentiation, and apoptosis. The major classes of HDIs include shortchain fatty acids, hydroxamic acid derivatives, synthetic benzamide derivatives, and cyclic tetrapeptides. Members of each of these classes have now entered clinical trials in humans. Despite their shared capacity to trigger histone deacetylation, individual HDIs exert diverse actions on cell cycle regulatory, signal transduction, and survival-related proteins which in all probability accounts for their disparate actions. Major areas of investigation surrounding HDIs include elucidating the mechanisms by which they induce apoptosis in neoplastic cells, and characterizing the factors responsible for the decision of such cells to undergo maturation versus cell death in the response to these agents. In this context, attention has recently focused on the ability of HDIs to induce perturbations in cell cycle regulatory proteins (e.g., p21(CIP1)), downregulation of survival signaling pathways (e.g., Raf/MEK/ERK), and disruption of cellular redox state (e.g., induction of reactive oxygen species; ROS). Aside from efforts to combine HDIs with established cytotoxic drugs, attempts are underway to establish a rational basis for combining HDIs with differentiation- inducing agents (e.g., ATRA, hypomethylating agents such as 5'-deoxyazacytine) with the goal of triggering re-expression of turn or suppressor and/or differentiation-associated genes. Finally, the results of recent preclinical studies provide a strong rationale for combining HDIs with other novel, molecularly targeted agents, including inhibitors of survival signaling pathways or cell cycle progression. Collectively, these findings should provide a fertile environment for the development of novel HDI-containing regimens in the treatment of cancer for many years to come.
Nasal Preparations in the Pharmacy : ear, nose & throat (2016)

Nasal preparations are available as irrigations, sprays, drops, gels and ointments. Irrigations are often used to clean the nasal passages from mucus and allergens and also as preparation before medicated products. Other nasal products are used to treat and prevent nasal symptoms such as dryness, congestion, itching, sneezing and infections. Nasal preparations work locally with fewer systemic sideeffects and may therefore be preferred over oral therapy. This article provides an overview of the products available over the counter in South Africa and their proper use.
George Cosgrave, 1870-1945 (1945)

News| December 01 1945 George Cosgrave, 1870-1945 Ben R. Walker Ben R. Walker Search for other works by this author on: This Site PubMed Google Scholar California Historical Society Quarterly (1945) 24 (4): 375–376. https://doi.org/10.2307/25155944 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Ben R. Walker; George Cosgrave, 1870-1945. California Historical Society Quarterly 1 December 1945; 24 (4): 375–376. doi: https://doi.org/10.2307/25155944 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCalifornia History Search This content is only available via PDF. Copyright 1945 The California Historical Society Article PDF first page preview Close Modal You do not currently have access to this content.
Orthogonal periodic sequences derived from M-sequences on GF(q) (2002)

A novel algorithm is proposed to generate orthogonal periodic sequences whose components consists of at most q complex numbers. In this algorithm, orthogonal periodic sequences are generated by means of mapping M-sequences on GF(q) into complex periodic sequences. The mapping functions are obtained by analytically solving a simultaneous nonlinear equation. The mathematical properties are studied, and it is shown that polyphase orthogonal periodic sequences and real orthogonal periodic sequences are derived as the particular cases of the orthogonal periodic sequences.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Asymmetric leaf development and blade expansion in <i>Arabidopsis</i> are mediated by KANADI and YABBY activities (2004)

Asymmetric development of plant lateral organs is initiated by a partitioning of organ primordia into distinct domains along their adaxial/abaxial axis. Two primary determinants of abaxial cell fate are members of the KANADI and YABBY gene families. Progressive loss of KANADI activity in loss-of-function mutants results in progressive transformation of abaxial cell types into adaxial ones and a correlated loss of lamina formation. Novel, localized planes of blade expansion occur in some kanadi loss-of-function genotypes and these ectopic lamina outgrowths are YABBY dependent. We propose that the initial asymmetric leaf development is regulated primarily by mutual antagonism between KANADI and PHB-like genes, which is translated into polar YABBY expression. Subsequently, polar YABBY expression contributes both to abaxial cell fate and to abaxial/adaxial juxtaposition-mediated lamina expansion.
Identification of novel arachidonic acid metabolites formed by prostaglandin H synthase (1987)

The metabolism of [1-14C]arachidonic acid by microsomal and purified prostaglandin (PG) H synthase was investigated. HPLC analysis confirmed that arachidonic acid (20:4) was extensively converted into prostaglandin G2 (PGG2) and/or prostaglandin H2 (PGH2) but several minor labelled products were formed in addition. Their formation, mediated by PGH synthase was established by inhibition with aspirin and indomethacin [Hecker, M., Hatzelmann, A. & Ullrich, V. (1987) Biochem. Pharmacol. 36, 851–855]. Upon comparison with authentic reference material these unknown PGH synthase metabolites were identified with respect to chromatographic properties, ultraviolet spectroscopy and mass spectrometry as 11 (R)-hydroperoxy-5Z,8Z,12E,14Z-eicosatetraenoic acid (11-OOH-20:4), 12(S)-hydroperoxy-5Z,8E,10E-heptadecatrienoic acid (OOH-17:3), 12(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid (OH-17:3), 15(RS)-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (15-OOH-20:4), 15(RS)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (15-OH-20:4), 13-hydroxy-5Z,14Z-prostaglandin H2, 15(S)-hydroxy-8-iso-5Z,13E-prostaglandin H2 and 15-oxo-prostaglandin H2. Unlike PGG2 and PGH2, 8-iso-PGH2, 13-hydroxy-PGH2 and 15-oxo-PGH2 failed to induce aggregation of washed human platelets and to form thromboxane upon incubation with homogeneous human platelet thromboxane synthase. In contrast to the formation of OOH-17:3, 15-oxo-PGH2 and OH-17:3 which can be attributed to the heme-catalyzed decomposition of PGG2 and PGH2, 11-OOH-20:4, 15-(O)OH-20:4-, 8 iso-PGH2 and 13-hydroxy-PGH2 represent potential side products of arachidonic acid conversion into PG endoperoxides. Their formation allows to conclude on PGH synthase mechanism and its intermediates for which an extended reaction scheme is proposed.
Characterizing thread placement in the IBM POWER7 processor (2012)

There is a clear trend in current processor design towards the combination of several thread level parallelism paradigms on the same chip, exemplified by processors such as the IBM POWER7. In those processors, the way threads are assigned to different hardware contexts, denoted thread placement, plays a key role in improving overall performance. In this paper we analyze the thread placement problem in the IBM POWER7 processor. Under each thread placement setup we analyze in detail how hardware resources are shared among running threads. We show to which extent a software designer can characterize an application on the POWER7 and based on that characterization, select the best thread placement configuration to improve a target metric. Our results show that a 54% reduction in execution time can be obtained (11.2% on average) when running pairs of desktop parallel applications under the appropriate thread placement.
Change in Raw Material Base in the Chemical Industry (2008)

Abstract The change in raw material base is nothing new to the chemical industry, it has always generated a wave of innovation and an economic boom. A prerequisite for this is the early development of scientific and technological bases for a renewed raw material change. Even the chemical industry, being well acquainted with the laws of nature, should not aim for future growth but for sustainability in order to be able to satisfy the demand for raw materials, increasing disproportionately to the world's population expected to stand at nine billion by 2050.
ReLooper: Refactoring for Loop Parallelism (2009)

In the multicore era, sequential programs need to be refactored for parallelism. The next version of Java provides ParallelArray, an array data structure that supports parallel operations over the array elements. For example, one can\napply a procedure to each element, or reduce all elements to a new element in parallel. Refactoring an array to a ParallelArray\nrequires (i) analyzing whether the loop iterations\nare safe for parallel execution, and (ii) replacing loops with the equivalent parallel operations. When done manually, these tasks are non-trivial and time-consuming. We present ReLooper, an Eclipse-based refactoring tool, that performs\nthese tasks automatically. Experience with refactoring real programs shows that ReLooper is useful: it reduces the burden of analyzing and rewriting parallel loops, and it is fast enough to be used interactively.
Interleaved Four-Phase Buck-Based Current Source With Isolated Energy-Recovery Scheme for Electrical Discharge Machining (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper presents the interleaved four-phase buck-based current source in continuous conduction mode with proposed isolated energy-recovery scheme for electrical discharge machining (EDM). EDM requires a pulse current with high slew rate in the output current of the current source. The interleaving technique allows the output slew rate of the buck-based current source to be improved due to the existence of the paralleled inductors at the start of discharge. The proposed isolated energy-recovery scheme provides a major path for the inductor to release its stored energy, thus avoiding high voltage stress in the output terminal when the gap reverts to the high-impedance state. The energy stored in the inductor is recycled to the input capacitor and can be reused for machining. The experimental results validate that the output current slew rate is high and that the energy is recovered when the gap is in the high-impedance state. </para>
Making sense of sensing systems (2002)

This paper borrows ideas from social science to inform the design of novel "sensing" user-interfaces for computing technology. Specifically, we present five design challenges inspired by analysis of human-human communication that are mundanely addressed by traditional graphical user interface designs (GUIs). Although classic GUI conventions allow us to finesse these questions, recent research into innovative interaction techniques such as 'Ubiquitous Computing' and 'Tangible Interfaces' has begun to expose the interaction challenges and problems they pose. By making them explicit we open a discourse on how an approach similar to that used by social scientists in studying human-human interaction might inform the design of novel interaction mechanisms that can be used to handle human-computer communication accomplishments
Ictal laryngospasm monitored by video‐EEG and polygraphy: a potential SUDEP mechanism (2018)

A 56-year-old man with refractory bitemporal epilepsy was monitored in the Epilepsy Monitoring Unit (EMU). In a video-EEG captured seizure, brief oroalimentary automatisms were followed by increased inspiratory effort, accompanied by prominent, visible tracheal movements and audible inspiratory stridor. The patient's oxygen saturation rapidly declined to 62%; persistent severe hypoxemia ended with spontaneous effective respiration commencing at seizure end. Subsequent seizures necessitated intensive care unit admission for respiratory distress, and ventilator support. This case suggests that ictal laryngospasm, a rare seizure manifestation, may represent another potential mechanism of sudden unexpected death in epilepsy (SUDEP). [Published with video sequence on www.epilepticdisorders.com].
Energy-efficient wireless communications: tutorial, survey, and open issues (2011)

With explosive growth of high-data-rate applications, more and more energy is consumed in wireless networks to guarantee quality of service. Therefore, energy-efficient communications have been paid increasing attention under the background of limited energy resource and environmental- friendly transmission behaviors. In this article, basic concepts of energy-efficient communications are first introduced and then existing fundamental works and advanced techniques for energy efficiency are summarized, including information-theoretic analysis, OFDMA networks, MIMO techniques, relay transmission, and resource allocation for signaling. Some valuable topics in energy-efficient design are also identified for future research.
How do NGOs Need Strengthening? (1997)

We have discussed elsewhere1 that much of the current interest in the role of NGOs is derived from a widely accepted, if largely unproven, thesis of NGO comparative advantage over government. This is usually associated with a number of frequently quoted and generalized positive attributes of NGOs.2 The recent widespread promotion of NGOs as effective alternative service providers, especially within the health sector, is part of this assumed paradigm of inherent competence. What, however, is less frequently discussed is the unlikelihood of all NGOs possessing all of these attributes. Whilst any country-based assessment of individual NGOs is likely to identify individual examples of well organized and carefully managed NGO projects and programmes, there is little evidence to support claims that this can be generalized throughout the whole NGO sector, or for all types of activity Unlike government agencies, NGOs cannot call upon the support of experienced civil servants. The large body of management theory and training available to the private-for-profit sector is inappropriate, and, until very recently at least, there has been no management theory developed specifically for the NGO sector.3 Nevertheless NGOs have to balance the need to conform to their governing instrument and the altruism of their original organizational objectives with maintaining managerial legitimacy and the ability to respond to changing situations.
Syntheses and Antimalarial Activities of 10-Substituted Deoxoartemisinins (2000)

Two series of 10-substituted deoxoartemisinin derivatives have been synthesized. The first employed the reaction of dihydroartemisinin acetate with several silyl enol ethers in the presence of titanium tetrachloride. The second utilized the reaction of 10-(2-oxoethyl)deoxoartemisinin with several Grignard reagents. The in vitro antimalarial activities of both series were determined against two drug-resistant clones of P. falciparum. The activities of 13 beta and 15 beta were 5-7 times greater than that of artemisinin.
CD4<sup>+</sup>T-Cell–Dependent Reduction in Hepatitis C Virus–Specific Neutralizing Antibody Responses After Coinfection With Human Immunodeficiency Virus (2015)

Depletion of CD4(+) T cells by HIV infection results in a global decline in the anti-HCV envelope antibody response, including binding antibody titers, nAb titers, and nAb breadth.
PKC-Dependent Stimulation of Exocytosis by Sulfonylureas in Pancreatic β Cells (1996)

Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic beta cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (KATP channels) in the beta cell membrane, causing membrane depolarization, calcium influx, and activation of the secretory machinery. In addition to these effects, sulfonylureas also promoted exocytosis by direct interaction with the secretory machinery not involving closure of the plasma membrane KATP channels. This effect was dependent on protein kinase C (PKC) and was observed at therapeutic concentrations of sulfonylureas, which suggests that it contributes to their hypoglycemic action in diabetics.
The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation (2016)

Meiotic recombination is induced by the formation of DNA double-strand breaks (DSBs) catalyzed by SPO11, the ortholog of subunit A of TopoVI DNA topoisomerase (TopoVIA). TopoVI activity requires the interaction between A and B subunits. We identified a conserved family of plant and animal proteins [the TOPOVIB-Like (TOPOVIBL) family] that share strong structural similarity to the TopoVIB subunit of TopoVI DNA topoisomerase. We further characterize the meiotic recombination proteins Rec102 (Saccharomyces cerevisiae), Rec6 (Schizosaccharomyces pombe), and MEI-P22 (Drosophila melanogaster) as homologs to the transducer domain of TopoVIB. We demonstrate that the mouse TOPOVIBL protein interacts and forms a complex with SPO11 and is required for meiotic DSB formation. We conclude that meiotic DSBs are catalyzed by a complex involving SPO11 and TOPOVIBL.
Spannungsverteilung im Eintragungsbereich des Spannbetonbalkens mit unmittelbarem Verbund. (1975)

Abstract Es wird der Spannungszustand im Eintragungsbereich des parallelgurtigen Spannbettbalkens mit einfachsymmetrischem I‐Querschnitt infolge Vorspannung mit sofortigem Verbund untersucht. Der Steg des Balkens wird dabei als elastische Rechteckscheibe aufgefasst, deren Längskanten mit Verstärkungsrippen versehen sind. Anhand von Zahlenrechnungen werden die Einflüsse von Querschnittsform, Querschnittshöhe, Übertragungslänge der Spannglieder und seitlichen Stegverdickungen im Endbereich untersucht.
F7 and type 1-like fimbriae from three Escherichia coli strains isolated from urinary tract infections: protein chemical and immunological aspects (1982)

Fimbriae from three Escherichia coli strains, C1212, C1214, and C1023, isolated from urinary tract infections, have been purified and characterized by determination of the N-terminal sequences, amino acid composition, and molecular weights of their respective subunits. Furthermore, their immunological interrelationships have been investigated. The three strains all harbored more than one fimbrial species each. Immunologically different type 1-like fimbriae, termed 1A, 1B, and 1C, with highly homologous N-terminal sequences were isolated, of which strain C1212 possessed 1A and 1C, strain C1214 possessed 1A and 1B, and strain C1023 possessed 1A and 1C. Type 1A is known to cause a mannose-sensitive hemagglutination similar to that described for type 1 fimbriae, whereas the functions of types 1B and 1C are not yet known. Strain C1212, in addition, harbored the F7 fimbrial antigen which causes mannose-resistant hemagglutination and adherence to urinary epithelial cells. The N-terminal structure of this antigen seems to indicate a possible evolutionary kinship to the type 1-like fimbriae, although they are immunologically unrelated. Our results indicate that fimbriation of pathogenic wild-type strains can be of an intricate variety.
The role of the carbohydrate moiety in the biologic properties of fibrinogen. (1984)

The carbohydrate moiety of some glycoproteins influences their secretion and functional properties. We have examined the importance of the oligosaccharide chains of fibrinogen in this regard. Fibrinogen was labeled de novo by the addition to rabbit hepatocyte monolayer cultures of either 3H-amino-acids or [2-3H] mannose, in the presence or absence of tunicamycin, a potent inhibitor of glycosylation. Inhibition of glycosylation, which ranged from 75 to 80%, was determined by incorporation of [2-3H]mannose as quantitated by gel filtration. Synthesis and secretion of fibrinogen were quantitated by 3H-amino-acid incorporation, using anti-fibrinogen immunoaffinity column chromatography of medium and cell homogenates. Tunicamycin did not appreciably inhibit fibrinogen synthesis, as compared to a 30-40% inhibition of overall protein synthesis, determined by incorporation of 3H-amino-acids into trichloroacetic acid-precipitable material. There was no evidence that secretion of fibrinogen was impaired. Fibrinogen from medium was copurified by adding cold plasma fibrinogen as carrier. Nonglycosylated fibrinogen was found to be functional as demonstrated by incorporation of radioactivity into clots of the copurified material at a rate identical to that of glycosylated fibrinogen. When clotted in the presence of Ca2+ and Factor XIII, cross-linking of glycosylated and nonglycosylated fibrin was demonstrable on fluorography of sodium dodecyl sulfate-polyacrylamide gels, showing disappearance of gamma-chain and appearance of gamma-gamma-dimers.