gebhart/patrepeval huggingface dataset:
The p24 family and selective transport processes at the ER—Golgi interface (2009)

The secretory pathway is of vital importance for eukaryotic cells and has a pivotal role in the synthesis, sorting, processing and secretion of a large variety of bioactive molecules involved in intercellular communication. One of the key processes in the secretory pathway concerns the transport of cargo proteins from the ER (endoplasmic reticulum) to the Golgi. Type-I transmembrane proteins of approximately 24 kDa are abundantly present in the membranes of the early secretory pathway, and bind the COPI and COPII coat complexes that cover vesicles travelling between the membranes. These p24 proteins are thought to play an important role in the selective transport processes at the ER-Golgi interface, although their exact functioning is still obscure. One model proposes that p24 proteins couple cargo selection in the lumen with vesicle coat recruitment in the cytosol. Alternatively, p24 proteins may furnish subcompartments of the secretory pathway with the correct subsets of machinery proteins. Here we review the current knowledge of the p24 proteins and the various roles proposed for the p24 family members.
FE65 Constitutes the Functional Link between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein (2004)

Increasing evidence has implicated the low density lipoprotein receptor-related protein (LRP) and the adaptor protein FE65 in Alzheimer's disease pathogenesis. We have shown previously that LRP mediates beta-amyloid precursor protein (APP) processing and affects amyloid beta-protein and APP secretion and APP-c-terminal fragment generation. Furthermore, LRP mediates APP processing through its intracellular domain. Here, we set out to examine whether this interaction is of direct or indirect nature. Specifically, we asked whether adaptor proteins such as FE65 influence the LRP-mediated effect on APP processing by forming a protein complex. In coimmunoprecipitation experiments, we confirmed the postulated APP-FE65 and the LRP-FE65 interaction. However, we also showed an LRP-FE65-APP trimeric complex using pull-down techniques. Because FE65 alters APP processing, we investigated whether this effect is LRP dependent. Indeed, FE65 was only able to increase APP secretion in the presence of LRP. In the absence of LRP, APP secretion was unchanged compared with the LRP knock-out phenotype. Using RNA short interference techniques against FE65, we demonstrated that a reduction in FE65 protein mimics the LRP knock-out phenotype on APP processing. These results clearly demonstrate that FE65 acts as a functional linker between APP and LRP.
Mechanisms of persistent atrial fibrillation (2013)

Identifying upstream strategies targeting molecular pathways that are common to fibrosis and electrical remodeling leading to atrial fibrillation perpetuation is highly desirable. This would facilitate finding new target genes with pleiotropic effects on the expression of ion channel proteins in myocytes and profibrotic molecules in nonmyocyte cells that are important for pathologic remodeling, which could become an important goal in persistent atrial fibrillation therapy.
A Noninvasive Approach To Intracranial Pressure Monitoring (1982)

The ability to noninvasively monitor intracranial pressure would be a valuable aid to the diagnosis and treatment of hydrocephalus and mass lesions of the brain. An experiment is described that measures the acoustic properties of the skull, in animals, under normal and elevated intracranial pressures. Results show intracranial pressure strongly influences the acoustic response, and at least one feature of the response is related to intracranial pressure in a consistent manner.
Total homocysteine measurement in clinical practice (2000)

This review will primarily address methodological aspects of homocysteine measurement, highlighting changes since the subject was comprehensively reviewed in 1993, and will bring together practical information of relevance to laboratory planning or to providing an analytical service including homocysteine measurement. Because the physiological state of the patient during blood collection is often neglected, and because it has become apparent that the bloodsampling procedure may contribute considerably more variation to measurement of homocysteine than the total variation of the analytical procedures, the review will pay particular attention to the critical roles of controlled blood collection and sample processing.
ChemInform Abstract: Synthesis of Pyranose Nucleosides (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
OPTICAL PROPERTIES OF <font>GaN</font> GROWN ON <font>Si</font> (111) SUBSTRATES BY MOCVD (2005)

GaN epilayers were grown on Si (111) substrates by MOCVD. The optical properties of the samples under different growth conditions were characterized. The abnormal peaks of excitonic emissions related to cubic- GaN were observed on the samples under improper growth conditions based on the LT PL measurements. Also the peak intensity is much higher than that of hexagonal- GaN . The higher intensity of exciton peaks is attributed to the local quantum well formed between the hexagonal- and cubic- GaN . No exciton peaks of cubic- GaN were found on the sample using the optimal growth conditions.
USE OF THE HAZOP ANALYSIS FOR EVALUATION OF CVD REACTORS (1991)

Before equipment is installed at AT&T Bell Laboratories, Allentown, a hazard and operability (HAZOP) analysis is done. Through a systematic process, a team leader guides a group of knowledgeable individuals through the equipment design to discover the hazards and the operating range of the equipment. During this HAZOP analysis, the equipment engineer responsible for the CVD process becomes aware of all aspects of the equipment from the electrical and chemical hookup of the process chamber to the treatment of the effluent. At our facility, HAZOP analysis has proven to be an effective tool. We present a sample HAZOP analysis for an MOCVD installation along with the short, easy-to-use questionnaire that the responsible engineer completes before the HAZOP analysis begins.
Quantification of Polyphenolics and Their Antioxidant Capacity in Fresh Plums (2003)

Total phenolics, total flavonoids, and antioxidant capacity of 11 cultivars of fresh plums were determined using spectrophotometric methods. Identification and quantification of individual polyphenolics were performed using reversed-phase high-performance liquid chromatography equipped with a diode array detector. The total phenolic contents of various cultivars widely varied from 125.0 to 372.6 mg/100 g expressed as gallic acid equivalents. The level of total flavonoids in fresh plums ranged between 64.8 and 257.5 mg/100 g expressed as catechin equivalents. Antioxidant capacity, expressed as vitamin C equivalent antioxidant capacity (VCEAC), ranged from 204.9 to 567.0 mg/100 g with an average of 290.9 mg/100 g of fresh weight. Cv. Beltsville Elite B70197 showed the highest amounts of total phenolics and total flavonoids and the highest VCEAC. A positive relationship (correlation coefficient r (2)() = 0.977) was presented between total phenolics and VCEAC, suggesting polyphenolics would play an important role in free radical scavenging. The level of IC(50) value of superoxide radical anion scavenging activity of the plum cultivars ranged from 13.4 to 45.7 mg of VCEAC/100 g. Neochlorogenic acid was the predominant polyphenolic among fresh plums tested. Flavonols found in plum were commonly quercetin derivatives. Rutin was the most predominant flavonol in plums. Various anthocyanins containing cyanidin aglycon and peonidin aglycon were commonly found in all plums except for cv. Mirabellier and NY 101.
Design of a Maximally Permissive Liveness- Enforcing Petri Net Supervisor for Flexible Manufacturing Systems (2010)

Deadlock prevention plays an important role in the modeling and control of flexible manufacturing systems (FMS). This paper presents a novel and computationally efficient method to design optimal control places, and an iteration approach that only computes the reachability graph of a plant Petri net model once in order to obtain a maximally permissive liveness-enforcing supervisor for an FMS. By using a vector covering approach, a minimal covering set of legal markings and a minimal covered set of first-met bad markings (FBM) are computed. At each iteration, an FBM from the minimal covered set is selected. By solving an integer linear programming problem, a place invariant is designed to prevent the FBM from being reached and no marking in the minimal covering set of legal markings is forbidden. This process is carried out until no FBM can be reached. In order to make the considered problem computationally tractable, binary decision diagrams (BDD) are used to compute the sets of legal markings and FBM, and solve the vector covering problem to get a minimal covering set of legal markings and a minimal covered set of FBM. Finally, a number of FMS examples are presented to illustrate the proposed approaches.
Electrolithographic Investigations of the Hydrophilic Channels in Nafion Membranes (2005)

Nafion membranes are used as semisolid electrolytes in methanol and hydrogen fuel cells. The ion conduction takes place through those hydrophilic channels in the Nafion that can provide continuous pathways through the membrane. There is as yet limited information about the density, the size, and the shape of these channels. We have developed two electrochemical methods of visualizing the pore structure which involve the creation of metal lithographs using the membrane pores as templates. In the experiments, the membrane is supported on a flat solid surface on one side, and is in contact with an electrolyte on the other side. Using hydrogen-terminated n-doped Si(111), we deposited gold from an electrolyte containing a gold salt. The Au ions traverse the membrane through the pores, reach the silicon surface, and are spontaneously reduced. A metallic Au deposit is formed on the silicon surface, at the base of the hydrophilic channel. The Au deposits are imaged after the membrane is dissolved. Another method involves supporting the membrane on a Pt surface and depositing silver wires through the hydrophilic channels of the membrane. The scanning electron microscope pictures of these wires provide an image of the size and the shape of the hydrophilic channels.
Globally optimal control of self‐adjoint distributed systems (1983)

Abstract The partial differential equations of motion for an uncontrolled distributed structure can be transformed into a set of independent modal equations in terms of natural co‐ordinates. It is common practice to design control forces that recouple the modal equations so that the natural co‐ordinates for the open‐loop (uncontrolled) system cease to be natural co‐ordinates for the closed‐loop (controlled) system. This approach is referred to as coupled control. In contrast, the independent modal‐space control method is a natural control method, i.e. natural co‐ordinates for the open‐loop system remain natural co‐ordinates for the closed‐loop system. Moreover, natural control provides a unique and globally optimal closed‐form solution to the linear optimal control problem for the distributed structure. Indeed, discretization is not necessary. The optimal control forces are ideally distributed. The distributed control can be approximated by finite‐dimensional control, a process that does not require truncation of the plant. Two numerical examples are presented.
Nucleation, Growth, and Aggregation of Ag Clusters on Liquid Surfaces (1998)

We report the formation of large, branched silver aggregates after deposition of Ag on silicone oil surfaces. The origin of these ramified aggregates is traced to a two stage process, the first of which involves nucleation and growth of disk-shaped Ag clusters during deposition. In the subsequent stage after deposition, the clusters continue to diffuse on the liquid surface by Brownian motion and finally aggregate.
Fringes of Equal Inclination in the Double-Passed Michelson Interferometer (1961)

The formation of fringes of equal inclination in the double-passed Michelson interferometer is discussed and a theoretical expression is obtained for the intensity distribution in the interference pattern. It is shown that the intensity distribution in these fringes undergoes a periodic modulation as the path difference in the interferometer is varied. Accurate measurements are possible with these fringes using a photometric setting criterion.
Decatungstate as an efficient photocatalyst in organic chemistry (2009)

In view of its unique photocatalytic properties, decatungstate (W(10)O(32)(4-)) is rapidly emerging as a promising tool in organic chemistry. This tutorial review surveys recent developments in the chemistry of decatungstate, including mostly synthetic, and to a lesser extent mechanistic aspects. We have chosen to present several representative examples that illustrate the diverse uses of decatungstate in organic synthesis. Thus, the decatungstate-mediated radical functionalization of several classes of organic compounds such as alkanes, alkenes, alcohols, aldehydes and sulfides, under both aerobic and anaerobic conditions, represents reactions of fundamental and practical interest in academia and industry. Several new discoveries concerning the heterogenization of decatungstate for the development of sustainable methods with broad applications in catalysis, such as the photooxidation or photodegradation of various organic substrates, are also presented.
Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma1 (2004)

A high platelet count is associated with tumor progression and poor survival in patients with esophageal carcinoma.
Sequential optical coherence tomography and confocal imaging (2004)

We report a system capable of sequentially acquiring two en-face images of different depth resolutions. The two images are generated by use of different principles, optical coherence tomography (OCT) and confocal microscopy, and have depth resolutions, at present, of better than 20 microm and over 0.12 mm, respectively. The lower-depth-resolution image is ideal for target positioning before collection of stacks of en-face OCT images. Switching between the two types of image by flipping an opaque screen in the reference arm, coupled with self-adjusting gain operation of avalanche photodiodes in the receiver. We illustrate the usefulness of the system by imaging a leaf and an optic nerve in vivo.
Electrophoresis experiment. Experiment MA-014 (1976)

A continuous free-flow electrophoresis study was conducted during the Apollo-Soyuz Test Project Mission to investigate and evaluate the increase in sample flow rate and sample resolution achievable in space. The electrophoresis equipment was designed for the separation of four mixtures of biological cells with variable sample flow rates, buffer flow rates, and electric field gradients. Separation quality was assessed by measuring the light from a quartz lamp through the electrophoresis channel and onto a photodiode system. The data evaluation indicates that all monitored systems operated correctly during the experiment. The optical system produced a light that was too bright to discern true cell distributions, but final analysis of scientific data by computer processing shows the expected distribution of separated cells.
Determination of dextromethorphan metabolic phenotype by salivary analysis with a reference to genotype in Chinese patients receiving renal hemodialysis* (1996)

Determination of dextromethorphan metabolic ratios in saliva is feasible in patients with renal failure requiring hemodialysis. All subjects in this study appeared to be "extensive metabolizer" phenotype for CYP2D6, and no poor metabolizer was identified. From the results with quinidine pretreatment, a metabolic ratio of 33 is suggested to be a tentative antimode for identification of poor metabolizers in patients with renal failure.
Image recovery from noisy transmission using soft bits and Markov random field models (2003)

A new method for robust image recovery from noisy transmis- sion based on soft bits and Markov random field modeling is proposed. The method aims to exploit the residual redundancy present in the sym- bols produced by a source encoder together with knowledge about the statistical properties of natural images. The soft-bit information required for reconstruction can be extracted either directly at the output of a noisy communication channel or at the output of a soft channel decoder (if channel codes are used). In the latter case, the proposed algorithm can also be used in conjunction with iterative channel decoding, resulting in joint source-channel turbo decoding. Examples are presented for the case where no channel codes are employed. The results obtained indi- cate that the proposed method yields very good performance even under extremely noisy conditions. © 2003 Society of Photo-Optical Instrumentation Engi- neers. (DOI: 10.1117/1.1603757)
A 1GSample/s, 15 GHz input bandwidth master-slave track-&-hold amplifier in InP-DHBT technology (2009)

A fully differential master-slave track-and-hold amplifier with 15 GHz input bandwidth is designed and fabricated in a 210-GHz-f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> InP-DHBT process on a 1.6times2.8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> chip. A Total Harmonic Distortion lower than -39 dB and a Third Harmonic Rejection greater than 45 dB are measured for 1 GSample/s and 4 dBm single-ended input signal. Time domain measurements are also presented.
Presidential Address: The Historical Bearing of Place-Name Studies: The Place of Women in Anglo-Saxon Society (1943)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Adaptive video-aware FEC-based mechanism with unequal error protection scheme (2013)

Real-time video services over wireless networks are becoming a part of everyday life and have been used to spread information ranging from education to entertainment content. However, the challenge of dealing with the fluctuating bandwidth, scarce resources and the time-varying error rate of theses networks, unveils the need for an error-resilient video transport. In this context, Forward Error Correction (FEC) approaches are required to provide the distribution of video applications for wireless users with Quality of Experience (QoE) assurance. This work proposes an adaptive cross-layer Video-Aware FEC mechanism with Unequal Error Protection (UEP) scheme to enhance video transmission in wireless networks, while increasing the user satisfaction and improving the usage of wireless resources. The benefit and impact of the proposed mechanism are demonstrated by using simulation and assessed through objective and subjective QoE metrics.
Electrooptical array processor for complex signals (1978)

An interdigital finger pattern is derived, which can modulate both the amplitude and phase of light in a total internal reflection configuration. An application to radio antenna array processing is illustrated.
Prospects for human papillomavirus vaccine development: emerging HPV vaccines (1998)

This review concentrates on recent advances in human papillomavirus vaccine development. Strategies for prophylactic HPV subunit vaccines utilizing recombinantly synthesized, immunogenic virus-like particles are discussed. Therapeutic strategies focusing on the induction of cell-mediated immunity and gene manipulation for the treatment of established HPV-associated disease are also reviewed.
Prinzmetal's variant angina: three case reports and a review of the literature. (1999)

Prinzmetal's variant angina is a rare entity. When angina-like symptoms occur at rest, mostly at a specific hour in the early morning, together with transient ST segment elevations and angiographically normal arteries, provocative tests with ergonovine or acetylcholine should be performed. Endothelial dysfunction, a strong thrombotic tendency, an increased platelet aggregation together with changes in autonomic tone can trigger coronary vasospasms. Once treated with calcium antagonists and nitrates the prognosis is excellent and severe complications such as arrhythmias, myocardial infarction or sudden death are extremely rare. Coronary stenting can be useful for refractory coronary spasm, CABG can be used for important coronary atherosclerosis. This review is illustrated with three typical presentations of variant angina: a myocardial infarction without significant organic coronary atherosclerosis, an ergonovine-induced coronary spasm with a non-significant coronary lesion and a multivessel spasm complicated by ventricular arrhythmia. All these three patients became asymptomatic after a treatment with calcium antagonists and nitrates.
Catalysts for hydroprocessing mixtures of heavy oil and coal (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalysts for hydroprocessing mixtures of heavy oil and coalJacques Monnier and Jerry F. KrizCite this: Ind. Eng. Chem. Prod. Res. Dev. 1986, 25, 4, 537–541Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/i300024a006https://doi.org/10.1021/i300024a006research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
MySpeechWeb (2008)

Few voice-in/voice-out applications are available on the web. One problem appears to be the lack of appropriate open-source tools. More speech applications would increase the functionality of the web for people with visual, cognitive, and motor disabilities. Our research group has developed open-source tools for the creation and deployment of speech applications by non-expert as well as expert users, and an open-source software platform to deploy those applications on the web. In addition, a suite of exemplar speech applications, together with documentation, has been built to facilitate the creation and deployment of similar applications by others.