gebhart/patrepeval huggingface dataset:
Design of an active exhaust attenuating valve for internal combustion engines (2001)

status: Published
ChemTS: an efficient python library for <i>de novo</i> molecular generation (2017)

Automatic design of organic materials requires black-box optimization in a vast chemical space. In conventional molecular design algorithms, a molecule is built as a combination of predetermined fragments. Recently, deep neural network models such as variational autoencoders and recurrent neural networks (RNNs) are shown to be effective in <i>de novo</i> design of molecules without any predetermined fragments. This paper presents a novel Python library ChemTS that explores the chemical space by combining Monte Carlo tree search and an RNN. In a benchmarking problem of optimizing the octanol-water partition coefficient and synthesizability, our algorithm showed superior efficiency in finding high-scoring molecules. ChemTS is available at https://github.com/tsudalab/ChemTS.
The trans-cardiac conductance method for on-line measurement of left ventricular volume: assessment of parallel conductance offset volume (2003)

The trans-cardiac conductance (TCC) method provides on-line left ventricular (LV) volume signals by determining the electrical conductance of blood in the LV by means of central venous and epithoracic electrodes. Conductive structures outside the LV blood pool cause a "parallel conductance" offset term (Vp) that can be determined by bolus injections of hypertonic saline in the pulmonary artery (Vp(saline)), which cause a transient increase in blood conductivity. This study in anesthetized sheep evaluates the accuracy of the saline calibration method and the variabilities of Vp between animals, between hemodynamic conditions and during the cardiac cycle. The conventional intra-cardiac conductance catheter method was used to obtain independent estimates of Vp by the zero-volume method (Vp(zero volume)). Mean baseline Vp(saline) and Vp(zerovolume) were 104 +/- 6 ml and 106 +/- 6 ml, respectively. Bland-Altman analysis showed a small nonsignificant bias (-2.5 ml) and narrow limits of agreement (4.6 ml). Vp was not significantly different between hemodynamic conditions (baseline, dobutamine, volume load, propranolol), but had a substantial interanimal variability (IAV) (38%). Average variations during the cardiac cycle were < 10% of mean Vp. We conclude that the saline method can be applied to determine Vp for TCC. IAV is substantial, so that Vp must be determined in each animal, but within-animal variability is relatively small.
<b>Coagulation of Colloidal Gold</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoagulation of Colloidal GoldB. V. Enustun and John. TurkevichCite this: J. Am. Chem. Soc. 1963, 85, 21, 3317–3328Publication Date (Print):November 1, 1963Publication History Published online1 May 2002Published inissue 1 November 1963https://pubs.acs.org/doi/10.1021/ja00904a001https://doi.org/10.1021/ja00904a001research-articleACS PublicationsRequest reuse permissionsArticle Views11172Altmetric-Citations968LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication (2011)

Reduced protein levels of ZNF198 and SUZ12 and elevated Plk1 occur during pX-mediated hepatocyte transformation in human liver cancer cell lines, as well as during HBV replication, underscoring the significance of these genes both in HBV-mediated HCC pathogenesis and HBV replication. We propose Plk1 activity down-regulates ZNF198 and SUZ12, thereby enhancing both HBV replication and pX-mediated oncogenic transformation.
Regional release and removal of catecholamines and extraneuronal metabolism to metanephrines (1995)

Norepinephrine (NIC) and epinephrine (JO) uro metabolized extra** neuronally by cateehol-O-melhyl-trnnHfornHe to Liu; tnetanephrinos (JVINh), normotanephrine (NMN) and motnnophrino (MN), Subjects in this study received in(iihìoiih of tritium-labeled NIO and 10, Concen trations ofMNs and catecholamines won» measured in plasma flowing into and out of the heart, forearm,kidneys, mesenteric organs (gastrointestinal tract, spleen, and pancreas), liver, at\d adrenals to examine t'ho regional production ofMNs from circulating and locally released catecholamines.NIO spillover* from mesenteric organs and kidneys accounted (or (>4% of the spillover from all tissues.There was detectable spillover of 10 from most extraadrenal tissues, butHlW was from the adrenals.The production ofMNs irom locally released and circulating catecholamines varied widely among tissues.The liver made the lardosi contribution to removal of circulating NIO (57%) and
Isolation and identification of short nucleotide sequences that affect translation initiation in <i>Saccharomyces</i> <i>cerevisiae</i> (2003)

In previous studies, we demonstrated the sufficiency of short nucleotide sequences to facilitate internal initiation of translation in mammalian cells. By using a selection methodology, we have now identified comparable sequences in Saccharomyces cerevisiae. For these studies, a library of constructs expressing dicistronic mRNAs with the HIS3 gene as the second cistron and 18 random nucleotides in the intercistronic region was introduced into a yeast strain in which the endogenous HIS3 gene was deleted. Untransformed cells or those containing the parent construct failed to grow on medium lacking histidine. Intercistronic sequences recovered from cells that did grow were evaluated by using various criteria. Fifty-six of the 18-nt sequences (approximately 1/400,000) functioned as synthetic internal ribosome entry sites (IRESes). The 14 most active sequences allowed growth in the presence of 0.1-0.6 mM 3-amino-1,2,4-triazole, a competitive inhibitor of the HIS3 gene product. In addition, eight sequences were identified that were not IRESes, but that enhanced HIS3 expression by an alternative mechanism that depended on the 5' end of the mRNA and appeared to involve either shunting or reinitiation. Comparisons among the 56 selected IRESes identified eight significant sequence matches containing up to 10 nucleotides. Many of the selected sequences also contained extensive complementary matches to yeast 18S rRNA, some at overlapping sites. The identification of cis sequences that facilitate translation initiation in yeast enables detailed biochemical and genetic analyses of underlying mechanisms and may have practical applications for bioengineering.
The efficacy of topical Royal Jelly on diabetic foot ulcers healing: A case series. (2011)

Royal Jelly dressing may be an effective method for treating diabetic foot ulcers besides standard treatments.
Gene transfection by laser cell surgery. (1987)

The exposure to a uv laser microbeam can modify a selected portion of cell membrane to be temporarily permiative, thereby allowing a foreign substance to enter living cell. As a first application of laser microbeam to the field of bionicis, the method was employed in incorporating the exogenous gene into cells. The method was found to offer a marked advantage over the existing ones in the success rate of gene incorporation, effi-ciency to large throughput, and in versatility to broad cell-type.
The new horizons of pharmacotherapy. Unexpected pharmacological actions and a new therapeutic strategy of phosphodiesterase–5 inhibitors (2014)

Researches reveal the efficacy of phosphodiesterase-5 inhibitors in LUTS along with an improvement of erectile function. The molecular mechanism of action of such drugs suggests imminent novel applications. Potential benefits will be multidimensional. Unfortunately, interfering with particular molecular mechanisms may alleviate some diseases, but may lay groundwork for others - new and even more devastating.
R Plasmids in <i>Corynebacterium xerosis</i> Strains (1983)

Plasmids coding for resistance to chloramphenicol, erythromycin, kanamycin, streptomycin, and tetracycline have been found in strains of Corynebacterium xerosis isolated from patients with otitis media.
Bayesian Blind Deconvolution From Differently Exposed Image Pairs (2010)

Photographs acquired under low-lighting conditions require long exposure times and therefore exhibit significant blurring due to the shaking of the camera. Using shorter exposure times results in sharper images but with a very high level of noise. In this paper we address the problem of utilizing two such images in order to obtain an estimate of the original scene and present a novel blind deconvolution algorithm for solving it. We formulate the problem in a hierarchical Bayesian framework by utilizing prior knowledge on the unknown image and blur, and also on the dependency between the two observed images. By incorporating a fully Bayesian analysis, the developed algorithm estimates all necessary model parameters along with the unknown image and blur, such that no user-intervention is needed. Moreover, we employ a variational Bayesian inference procedure, which allows for the statistical compensation of errors occurring at different stages of the restoration, and also provides uncertainties of the estimates. Experimental results with synthetic and real images demonstrate that the proposed method provides very high quality restoration results and compares favorably to existing methods even though no user supervision is needed.
Phosphotyrosine as a substrate of acid and alkaline phosphatases. (1985)

A new spectrophotometric method for following dephosphorylation of phosphotyrosine has been described. The absorption spectra of phosphotyrosine and tyrosine were plotted over the pH range from 3 to 9. The change in absorbance accompanying the conversion of phosphotyrosine to tyrosine was the greatest at 286 nm. The difference absorption coefficients were calculated for several pH values. Dephosphorylation of phosphotyrosine by acid phosphatases from human prostate gland, from wheat germ and potatoes obeys the Michaelis-Menten equation, whereas alkaline phosphatases calf intestine and E. coli are inhibited by excess of substrate.
[Disseminated Mycobacterium avium infection in three patients with hematologic diseases]. (1997)

We report three cases of disseminated Mycobacterium avium complex infection in immunocompromised haematological patients. We conclude that in haematological patients with longlasting fever of unknown cause Mycobacterium avium complex infection should be considered and the relevant cultures from blood and bone marrow should be done.
A novel composite coupled hardness with flexibleness—polylactic acid toughen with thermoplastic polyurethane (2011)

Abstract With the aim to modify the brittleness of polylactic acid (PLA), it was firstly melt blended with thermoplastic polyurethane (TPU) at six different PLA wt % of 100, 90, 80, 70, 60, and 50 compositions. The properties of PLA/TPU composite were characterized by means of electron microscopy, rheological, mechanical and thermal methods. The results showed that the brittle fracture of pure PLA was gradually transformed into ductile fracture with the addition of the TPU elastomer. The notched impact strength of the composite at 10 wt % TPU was over three times higher than that of pure PLA. The composite was found to be a partially miscible system with shifted glass transition temperatures. The molten blend was shear‐thinning fluid and it could be processed by conventional thermoplastic processes such as extrusion and injection molding. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Improvements of ’’<i>i</i> <i>n</i> <i>s</i> <i>i</i> <i>t</i> <i>u</i>’’ multifilamentary Nb3Sn superconducting wires (1979)

’’In situ’’ multifilamentary Nb3Sn wires with improved high-field properties are reported. An overall critical current density greater than 104 A/cm3 is achieved at 14 T for a Cu–36 wt%–Nb–20 wt% Sn material. The results are comparable to the best reported commercial multifilamentary Nb3Sn materials.
Prognostic biomarkers for esophageal adenocarcinoma identified by analysis of tumor transcriptome (2010)

Background: Despite many attempts to establish pre-treatment prognostic markers to understand the clinical biology of esophageal adenocarcinoma (EAC), validated clinical biomarkers or parameters remain elusive. We generated and analyzed tumor transcriptome to develop a practical biomarker prognostic signature in EAC. Methodology/Principal Findings: Untreated esophageal endoscopic biopsy specimens were obtained from 64 patients undergoing surgery and chemoradiation. Using DNA microarray technology, genome-wide gene expression profiling was performed on 75 untreated cancer specimens from 64 EAC patients. By applying various statistical and informatical methods to gene expression data, we discovered distinct subgroups of EAC with differences in overall gene expression patterns and identified potential biomarkers significantly associated with prognosis. The candidate marker genes were further explored in formalin-fixed, paraffin-embedded tissues from an independent cohort (52 patients) using quantitative RT-PCR to
Mechanism of Zeolite A Nanocrystal Growth from Colloids at Room Temperature (1999)

The formation and growth of crystal nuclei of zeolite A from clear solutions at room temperature were studied with low-dose, high-resolution transmission electron microscopy in field emission mode and with in situ dynamic light scattering. Single zeolite A crystals nucleated in amorphous gel particles of 40 to 80 nanometers within 3 days at room temperature. The resulting nanoscale single crystals (10 to 30 nanometers) were embedded in the amorphous gel particles. The gel particles were consumed during further crystal growth at room temperature, forming a colloidal suspension of zeolite A nanocrystals of 40 to 80 nanometers. On heating this suspension at 80 degrees C, solution-mediated transport resulted in additional substantial crystal growth.
Modulation of the expression of murine lupus by gonadotropin-releasing hormone analogs (1994)

Recent studies have suggested that hypothalamic and pituitary hormones may directly influence the immune system. One such hormone with immunomodulatory properties is GnRH. We hypothesized that GnRH and/or the gonadotropins might alter the severity of autoimmune disease through mechanisms distinct from their effects on gonadal hormones. This possibility was tested in a murine model of lupus. We assessed disease severity over time in intact and castrated, male and female, lupus-prone (SWR x NZB) F1 hybrid mice during treatment with GnRH agonist, GnRH antagonist, or vehicle. Compared to vehicle administration, GnRH antagonist administration significantly decreased total serum immunoglobulin G and anti-DNA antibodies in castrated male and female mice and significantly improved survival. In contrast, GnRH agonist administration exerted reciprocal effects in castrated mice, leading to early increases in serum anti-DNA and total immunoglobulin G levels. We conclude that GnRH and/or the gonadotropins can modify the expression of murine lupus independently of their regulation of gonadal steroid secretion.
Purification and characterization of a 47 kDa protease from<i>Schistosoma mansoni</i>cercarial secretion (1992)

Fractionation of Schistosoma mansoni cercariae gland secretion on a Sephadex G-150 column followed by a Superose-12 column in an FPLC system, isolated a 47 kDa protease which migrated as a single band on SDS-PAGE gels. A monoclonal antibody (MAb) was produced which recognizes only the 47 kDa protease, and an immuno-affinity column with the MAb was used to isolate the protease. The 47 kDa protease showed activity on several macromolecules such as elastin and collagen type VI besides gelatin and casein. This suggests that this enzyme can be one of the enzymes that might facilitate invasion of the cercariae through host skin. The optimal pH of the protease against the synthetic substrate, Ac-Phe-Arg-Nan, in Tris-HCl buffer was 10. Experiments with protease inhibitors indicate that the purified enzyme is a serine protease.
Intelligent Pervasive Network Authentication: S/Key Based Device Authentication (2009)

The intelligent pervasive network environment is thing which invisible computer that is not shown linked mutually through network so that user may use computer always is been pervasive. As a number of pervasive network services are available and smart environment is expanding into ubiquitous computing environment, we need to protect intelligent pervasive environment system from illegal accesses and a variety of threats. Intelligent pervasive environment is exposed to various cyber attacks of Internet, involves hacking, malicious codes, worms, viruses, DoS attacks, and eavesdropping since it is connected to Internet. So in this paper, we propose authentication in a intelligent pervasive environment security for guaranteeing reliability and availability including authentication, authorization system. We proposed S/Key based authentication, scheme for secure remote access in intelligent pervasive environments. Furthermore, we describes smart environment authentication which is the basic and essential element in the pervasive network security. And our device authentication concept can offer pervasive network service users convenience and security.
Growth of the IB-RS-2 Pig Kidney Cell Line in Suspension Culture and Its Susceptibility to Foot-and-Mouth Disease Virus (1971)

The adaptation of the pig kidney cell line IB-RS-2, clone 60, to growth in suspension culture is described. When fully adapted, an approximate threefold increase in viable cells was obtained within 72 hr from initial cell concentrations of 5 x 10(5) per ml in culture volumes up to 1,500 ml. The monolayer cells (99th passage level) used to initiate the suspension cultures and the fully adapted suspension cells were shown to have an aneuploid chromosome karyotype, whereas earlier monolayer cultures (32nd passage level) had a pseudodiploid karyotype. Replicate virus titrations in monolayers prepared from suspension-adapted cells, IB-RS-2 monolayer cells, BHK monolayer cells, and in suckling mice showed that the suspension cells had retained sensitivity to foot-and-mouth disease virus. The geometric mean peak infectivity of seven strains of foot-and-mouth disease virus grown in IB-RS-2 suspension cells was 10(8.2) plaque-forming units per ml, with a mean complement-fixing activity of approximately 135 complement-fixing units per ml. These preliminary results indicate that submerged cultures of these cells on an industrial scale may be useful for commercial foot-and-mouth disease vaccine production.
Determination of Pore Size and Pore Wall Structure of MCM-41 by Using Nitrogen Adsorption, Transmission Electron Microscopy, and X-ray Diffraction (1999)

Highly ordered MCM-41 materials were synthesized using single or mixed alkyltrimethylammonium and alkyltriethylammonium surfactants of alkyl chain lengths from 12 to 22. As determined using combined adsorption/powder X-ray diffraction (XRD) analysis, the obtained samples exhibited pore sizes from 3.2 to 4.8 nm with about 0.3 nm increments. Nitrogen adsorption isotherms for the samples under study exhibited remarkably sharp capillary condensation steps. The adsorption isotherm for the highly ordered 4.8 nm MCM-41 featured a narrow hysteresis loop with parallel adsorption and desorption branches. This behavior is probably a feature of nitrogen adsorption in ideal cylindrical pores of this size and is distinctly different from the previously reported behavior of MCM-41 with pore sizes in the range 4−5.5 nm, which had triangular hysteresis loops on their nitrogen adsorption isotherms. All MCM-41 materials had remarkably narrow pore size distributions, which showed that fine-tuning of the pore size is easily achievable for the synthesis procedure used. The pore wall thickness was found to increase as the pore size increased. The pore wall thickness determined using transmission electron microscopy (TEM) was somewhat larger than that obtained using the combined XRD/adsorption analysis, which was attributed to inherent features of these determination methods. TEM images showed that pores of MCM-41 samples were approximately hexagonal rather than circular, thus providing structural information especially important for application of MCM-41 as a model adsorbent. Low-pressure adsorption studies of uncalcined ethanol-washed MCM-41 samples revealed that external surfaces of their particles were covered by relatively dense layers of surfactant ions. This behavior is consistent with the generally accepted mechanism of the MCM-41 formation via self-assembly of silicate−surfactant ion pairs. Comparison of adsorption isotherms for uncalcined and calcined samples allowed us to exclude the possibility of any appreciable structural degradation during calcination, although TEM provided some indication of the lowering of structural ordering upon calcination.
Efficient Algorithms for Shortest Paths in Sparse Networks (1977)

Algorithms for finding shortest paths are presented which are faster than algorithms previously known on networks which are relatively sparse in arcs. Known results which the results of this paper extend are surveyed briefly and analyzed. A new implementation for priority queues is employed, and a class of “arc set partition” algorithms is introduced. For the single source problem on networks with nonnegative arcs a running time of O (min( n 1+1/ k + e , n + e ) log n )) is achieved, where there are n nodes and e arcs, and k is a fixed integer satisfying k > 0. This bound is O ( e ) on dense networks. For the single source and all pairs problem on unrestricted networks the running time is O (min( n 2+1/ k + ne , n 2 log n + ne log n ).
Active contour road model for smart vehicle (2002)

We propose a method to solve the general problem of road tracking and 3D-shape reconstruction for a smart vehicle. The method assumes that the road boundaries are parallel and that the width of the road is constant. We then detect and track the road region in the image using active contour models subject to a parallelism constraint. The system then generates a 3D-road model from a single image. We evaluate the effectiveness of the method by applying to real road scenes comprising more than 2000 images.