gebhart/patrepeval huggingface dataset:
Targeting DNA and Topoisomerase I with Indolocarbazole Antitumor Agents (2002)

This chapter contains sections titled: Introduction Naturally Occurring Indolocarbazoles Staurosporine and Analogs with a Pyranose Sugar Moiety K252a and Analogs with a Furanose Sugar Moiety Rebeccamycin AT2433 Synthetic Indolocarbazole Derivatives Targeting DNA and Topoisomerase I Influence of Chloro and Bromo Substituents on the IND Chromophore Modification of the Imide Heterocycle Halogenoacetyl Derivatives Glucose and Galactose Derivatives: Stereospecific DNA Recognition From Rebeccamycin to Staurosprine-type Analogs Amino Sugar Derivatives Methylation of the Indole Nitrogen Indolo[2,3-c]carbazole Rebeccamycin Dimers and Conjugates Design of a tumor-active compound: NB-506 From BE13793C to ED-110 and NB-506 DNA Binding and Topoisomerase I Inhibition Cytotoxicity and Apoptosis NB-506-resistant Cell Lines Antitumor Activity Inhibition of the Topoisomerase I Kinase Activity A Novel Clinical Candidate: J-107088 Biosynthesis Conclusion
Cranberry and blueberry: Evidence for protective effects against cancer and vascular diseases (2007)

Growing evidence from tissue culture, animal, and clinical models suggests that the flavonoid-rich fruits of the North American cranberry and blueberry (Vaccinium spp.) have the potential ability to limit the development and severity of certain cancers and vascular diseases including atherosclerosis, ischemic stroke, and neurodegenerative diseases of aging. The fruits contain a variety of phytochemicals that could contribute to these protective effects, including flavonoids such as anthocyanins, flavonols, and proanthocyanidins; substituted cinnamic acids and stilbenes; and triterpenoids such as ursolic acid and its esters. Cranberry and blueberry constituents are likely to act by mechanisms that counteract oxidative stress, decrease inflammation, and modulate macromolecular interactions and expression of genes associated with disease processes. The evidence suggests a potential role for dietary cranberry and blueberry in the prevention of cancer and vascular diseases, justifying further research to determine how the bioavailability and metabolism of berry phytonutrients influence their activity in vivo.
Binding sites for adeno-associated virus Rep proteins within the human genome (1997)

The Rep proteins of adeno-associated virus type 2 (AAV) are known to bind to Rep recognition sequences (RRSs) in the AAV inverted terminal repeats (ITRs), the AAV p5 promoter, and the preferred AAV integration site in human chromosome 19, called AAVS1. Integration of the AAV genome into AAVS1 appears to be mediated by an interaction between the Rep proteins of AAV and Rep binding sites within the viral genome and the integration locus. In an attempt to identify potential alternate integration sites, we looked for recognition sites for AAV Rep proteins in the human genome by performing a BLASTN computerized homology search. We used the 16-mer core sequences of the RRSs in the AAV ITRs and AAVS1 separately as query sequences and identified 18 new RRSs in or flanking the genes coding for the following: tyrosine kinase activator protein 1 (TKA-1); colony stimulating factor-1; insulin-like growth factor binding protein 2 (IGFBP-2); histone H2B.1; basement membrane heparan sulfate proteoglycan, also known as perlecan; the AF-9 gene product, which is involved in the chromosomal translocation t (9:11)(p22:q23); the betaB subunit of the hormone known as inhibin; interleukin-2 enhancer binding factor; an endoplasmic reticulum-Golgi intermediate compartment resident protein called p63; a global transcription activator (hSNF2L); the beta-actin repair domain; a retinoic acid-inducible factor, also known as midkine; a breast tumor autoantigen; a growth-arrest- and DNA-damage-inducible protein called gadd45; the cyclin-dependent kinase inhibitor called KIP2, which inhibits several G1 cyclin-cyclin-dependent kinase complexes; and the hereditary breast and ovarian cancer gene (BRCA1). RRSs were also identified in a newly discovered open reading frame on chromosome 10 and in the ERCC1 locus on human chromosome 19. The ability of a maltose binding protein-Rep68 fusion protein to bind to these sequences was confirmed by electrophoretic mobility shift assays. These sites may serve as alternate integration sites for AAV or play a role in Rep-mediated effects on human cells.
Sintering nano-particles on low temperature materials (2006)

Direct Writing (or Printing) technologies use nano-particle inks and pastes to build mesoscale-scale devices. The term mesoscale refers to sizes from approximately 10 microns to 1000 microns, and covers the range between geometries deposited with the more conventional thin film and thick film processes. These processes begin with dispensing of liquid molecular precursors or colloidal suspensions of metal, dielectric, ferrite, or resistor nano-powders. The dispensing is accomplished by either controlling an aerosol stream or bead of thick viscous paste to produce features with dimensions as small as 10 microns. In a typical configuration, the substrate is placed on a platen that is attached to a high precision CAD/CAM stages, so that intricate geometries may be produced. Either laser, photonic or furnace thermal treatments is used to process the deposit to the desired state. Application of these technologies to the production of direct write inductors, capacitors, and resistors is presented, along with electrical characterization of these components.
Triple negative breast cancer: an Indian perspective (2015)

TNBC forms a large proportion of carcinoma breast patients in a central Indian scenario and needs more research to identify appropriate treatment planning considering aggressive histology and advanced presentation.
Establishment of Cellobiose Utilization for Lipid Production in Rhodococcus opacus PD630 (2013)

Rhodococcus opacus PD630, which is known for its ability to accumulate large amounts of triacylglycerols (TAG), was metabolically engineered, and a cellobiose utilization pathway was introduced. Activities of β-glucosidases were determined, and recombinant strains accumulated fatty acids up to 39.5 ± 5.7% (wt/wt) of cell dry mass from cellobiose.
Nicotinic Anhydride (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNicotinic AnhydrideC. O. BadgettCite this: J. Am. Chem. Soc. 1947, 69, 9, 2231Publication Date (Print):September 1, 1947Publication History Published online1 May 2002Published inissue 1 September 1947https://pubs.acs.org/doi/10.1021/ja01201a502https://doi.org/10.1021/ja01201a502research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of in-situ laser vacuum annealing and sealing processes for an application to field emission displays (2002)

A laser irradiation technique is increasingly becoming one of viable candidates for in-situ and in-line packaging of field emission displays (FED) in their near-future mass production. A high power laser was used for laser annealing as well as laser sealing processes. The former is to clean field emitter arrays (FEAs) and the latter is to melt glass frit between two glass plates by an local irradiation of a laser beam along the edges of a panel. In addition, seal-capping and getter activation processes were sequentially carried out while not breaking a vacuum inside a FED panel.
Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region (2018)

More than 20 years after the first outbreaks, the phylogenetic picture of PRRSV is still incomplete and full of gaps, especially in regards of PRRSV 1. Due to the exceptional diversity observed at the eastern borders of Europe and the low number of available sequences from Central Eastern European countries, the authors collected and analyzed both recent as well as already submitted sequences comparing them to a large backbone set of available ORF5 sequences representing the full spectrum of PRRSV 1 Subtype 1 diversity to conduct a systematic phylogenetic analysis and reclassification elucidating the diversity of the virus in these countries. Moreover, further analyses of the EUROSTAT data regarding the live pig movement trends revealed their influence of virus diversity and evolution. The results indicate that besides the effect of local, isolated divergent evolution and the use of modified live vaccines, the most important factor influencing a given country's virus diversity is the transboundary movement of live, infected animals.
Compiler support for automatic checkpointing (2003)

Checkpointing is a key technology for applications on large cluster computer systems. As cluster sizes grow, component failures will become a normal part of operation, and applications will have to deal more directly with repeated failures during program runs. We describe automatic checkpointing in the ZPL compiler and its advantages over traditional library or system-based approaches that have no information about application behavior. We show that even naive compiler-inserted checkpoints can significantly reduce the size of the checkpoint recovery data, up to 73% in our application suite. We also introduce the notion of checkpoint ranges, a range of code where processors can perform a local checkpoint at any time during the range. The compiler guarantees that these local checkpoints form a globally consistent checkpoint without global coordination by ensuring that there are no in-flight messages during the checkpoint range. Checkpoint ranges help further alleviate any additional network congestion caused by checkpointing.
AN IRRIGATION MODEL FOR MANAGEMENT OF LIMITED WATER SUPPLIES (1987)

A two-stage simulation/mathematical programming model is presented for determining the optimal intraseasonal allocation of irrigation water under conditions of limited water supply. The model is applied to a series of water shortage scenarios under both surface and center pivot irrigation. Economically efficient irrigation management is shown to involve the coordination of a number of managerial decisions, including irrigation scheduling, crop substitution, the adoption of improved irrigation labor practices, and idling land. The results indicate that significant opportunities exist for conserving water in the study area under both surface and center pivot irrigation.
Curcumin as a promising antifungal of clinical interest (2008)

The lack of antifungal compounds with reduced side effects highlights the importance of studying natural products for this purpose. Curcumin was a more potent antifungal than fluconazole against P. brasiliensis, the causal agent of the neglected disease paracoccidioidomycosis. Curcumin dramatically inhibited the adhesion of Candida species isolated from AIDS patients to BEC, demonstrating that curcumin is a promising lead compound that warrants further investigation into its therapeutical use in immunocompromised patients.
Follicle Stimulating Hormone Pattern and Luteal Function in Ewes Receiving Bovine Follicular Fluid during Three Stages of the Estrous Cycle2 (1987)

The objectives of this study were to determine 1) the ability of charcoal-extracted bovine follicular fluid (bFF) to suppress endogenous follicle stimulating hormone (FSH) at various stages of the estrous cycle and 2) the effects of suppression of FSH on luteal function and lengths of the current and subsequent estrous cycles. Twenty-six mature ewes were assigned randomly to receive 5 ml of either bFF or saline, subcutaneously, at 8-h intervals on d 1 through 5 (bFF n = 6; saline n = 3), d 6 through 10 (bFF n = 6; saline n = 3) or d 11 through 15 (bFF n = 6; saline n = 2) of the estrous cycle (d 0 = estrus). Blood was collected daily beginning at estrus and continued until the third estrus (two estrous cycles) or 40 d; more frequent samples were collected 2 h prior to initiation of treatment (0600), hourly for the first 8 h of treatment, then every 4 h until 0800 on the first day after treatment, and finally at 1600 and 2400 on that day. Plasma concentrations of FSH were lower (P less than .001) in bFF-treated than in saline-treated ewes. Treatment with bFF reduced (P less than .05) plasma concentrations of progesterone during the current but not during the subsequent estrous cycle. Treatment with bFF did not affect plasma concentrations of estradiol-17 beta. Administration of bFF on d 11 through 15 of the estrous cycle lengthened the interval from the decline in progesterone to estrus and the inter-estrous interval by approximately 3 and 4 d, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Phase Diagram at Low Temperature of the System ZrO2/Nb2O5 (2001)

Various compositions of the ZrO2/Nb2O5 system were synthesized and the experimental conditions for obtaining reproducible results were established. The gel was precipitated at constant pH = 10, aged at room temperature for 18 h and, after filtration, dried at 110 °C for 24 h. The phase diagram of the ZrO2/Nb2O5 system was established between 600 and 1300 °C. Phase transitions of ZrO2 and Nb2O5 were observed with XRD; and two ternary compounds, 6 ZrO2 · Nb2O5 and 12 Nb2O5 · ZrO2, were identified. The samples with a Nb2O5 content between approximately 10 and 40 mole% showed the greatest specific area and are thus best for use as catalyst supports. Phasendiagramm des Systems ZrO2/Nb2O5 bei niedriger Temperatur Das System ZrO2/Nb2O5 wurde in verschiedener Zusammensetzung dargestellt und die experimentellen Bedingungen für reproduzierbare Ergebnisse bestimmt. Das Gel wurde bei konstantem pH = 10 gefällt, 18 Stunden bei 20 °C gealtert und nach Filtration bei 110 °C getrocknet. Das Phasendiagramm des ZrO2/Nb2O5-Systems wurde zwischen 600° und 1300 °C bestimmt. Phasenübergänge von ZrO2 und Nb2O5 wurden röntgenographisch untersucht und zwei ternäre Phasen, nämlich 6 ZrO2 · Nb2O5 und 12 Nb2O5 · ZrO2, identifiziert. Die Proben mit einem Nb2O5-Gehalt zwischen 10 und 40 mol-% haben die größte spezifische Oberfläche und sind somit am besten für Katalysatoren geeignet
Analysis of Tow-Placed, Variable-Stiffness Laminates (1996)

It is possible to create laminae that have spatially varying fiber orientation with a tow placement machine. A laminate which is composed of such plies will have sti#ness properties which vary as a function of position. Previous work had modelled such variable-stiffness laminae by taking a reference fiber path and creating subsequent paths by shifting the reference path. This thesis introduces a method where subsequent paths are truly parallel to the reference fiber path. The primary manufacturing constraint considered in the analysis of variable-sti#ness laminates was limits on fiber curvature which proved to be more restrictive for parallel fiber laminae than for shifted fiber. The in-plane responses of shifted and parallel fiber variable-sti#ness laminates to either an applied uniform end shortening or in-plane shear were determined. Both shifted and parallel fiber variable-stiffness laminates can redistribute the applied load thereby increasing critical buckling loads compared to traditional straight fiber laminates. The primary differences between the two methods is that parallel fiber laminates are not able to redistribute the loading to the degree of the shifted fiber. This significantly reduces the increase in critical buckling load for parallel fiber variable-sti#ness laminates over straight fiber laminates.
Gene expression signatures for colorectal cancer microsatellite status and HNPCC (2005)

The majority of microsatellite instable (MSI) colorectal cancers are sporadic, but a subset belongs to the syndrome hereditary non-polyposis colorectal cancer (HNPCC). Microsatellite instability is caused by dysfunction of the mismatch repair (MMR) system that leads to a mutator phenotype, and MSI is correlated to prognosis and response to chemotherapy. Gene expression signatures as predictive markers are being developed for many cancers, and the identification of a signature for MMR deficiency would be of interest both clinically and biologically. To address this issue, we profiled the gene expression of 101 stage II and III colorectal cancers (34 MSI, 67 microsatellite stable (MSS)) using high-density oligonucleotide microarrays. From these data, we constructed a nine-gene signature capable of separating the mismatch repair proficient and deficient tumours. Subsequently, we demonstrated the robustness of the signature by transferring it to a real-time RT-PCR platform. Using this platform, the signature was validated on an independent test set consisting of 47 tumours (10 MSI, 37 MSS), of which 45 were correctly classified. In a second step, we constructed a signature capable of separating MMR-deficient tumours into sporadic MSI and HNPCC cases, and validated this by a mathematical cross-validation approach. The demonstration that this two-step classification approach can identify MSI as well as HNPCC cases merits further gene expression studies to identify prognostic signatures.
Parameter Analysis For Frequency-Modulation Reticle Design (1989)

We reached this modification through a useful discussion with Jacob Politch of the Technion-Israel Institute of Technology. In working out the above result, we referred to A Short Table of Integrals, 4th edition, by B. 0. Peirce, revised by R. M. Foster (Ginn & Co., Boston, 1956).
A Validated Grading Scale for Crow's Feet (2008)

The 5-point photonumeric scale generated spans the severity of the type of crow's feet for which patients most commonly seek correction. The scale is well stratified for consistent rating.
Effects of Topoisomerase I-targeted Drugs on Radiation Response of L5178Y Sublines Differentially Radiation and Drug Sensitive (1995)

The murine L5178Y (LY) lymphoma sublines, LY-R (radiation resistant) and LY-S (radiation sensitive) display a difference in susceptibility to camptothecin (CPT): LY-S cells are less sensitive to killing by this inhibitor of topoisomerase I than LY-R cells. Post-treatment (CPT present until 3 h after irradiation) sensitizes only LY-S cells. In agreement with this, only in LY-S cells is the relative number of DNA-protein cross-links formed after treatment with CPT + X higher than expected for additivity of X-ray and CPT-induced damage. The pattern of changes in the labelling indices and cell cycle distribution in cells that underwent combined treatment is essentially like that seen for single-agent treatment: for LY-S cells like that for radiation, for LY-R cells like that for CPT. We found no direct relation between the patterns of cell cycle distributions and the enhancement of the lethal effect of X-irradiation by CPT post-treatment. The sublines are not markedly differentially sensitive to beta-lapachone, which modifies topoisomerase I activity, and not sensitized to X-rays by post-irradiation treatment with the drug.
Why Are Viscosities Lower for Ionic Liquids with −CH<sub>2</sub>Si(CH<sub>3</sub>)<sub>3</sub> vs −CH<sub>2</sub>C(CH<sub>3</sub>)<sub>3</sub> Substitutions on the Imidazolium Cations? (2005)

We have prepared novel room temperature ionic liquids (RTILs) with trimethylsilylmethyl (TMSiM)-substituted imidazolium cations and compared the properties of these liquids with those for which the TMSiM group is replaced by the analogous neopentyl group. The ionic liquids are prepared with both tetrafluoroborate (BF(4)(-)) and bis(trifluoromethylsulfonyl)imide (NTf(2)(-)) anions paired with the imidazolium cations. At 22 degrees C, the TMSiM-substituted imidazolium ILs have shear viscosities that are reduced by a factor of 1.6 and 7.4 relative to the alkylimidazolium ILs for the NTf(2)(-) and BF(4)(-) anions, respectively. To understand the effect of silicon substitution on the viscosity, the charge densities have been calculated by using density functional theory electronic structure calculations. The ultrafast intermolecular, vibrational, and orientational dynamics of these RTILs have been measured by using femtosecond optical heterodyne-detected Raman-induced Kerr effect spectroscopy (OHD-RIKES). The intermolecular dynamical spectrum provides an estimate of the strength of interactions between the ions in the RTILs, and provides a qualitative explanation for the observed reduction in viscosity for the silicon-substituted RTILs.
Occupational nasal carcinogenesis among dentists? (1981)

671 dentists were registered in Alberta for 1973. In that year two dentists presented at the Cross Cancer Institute with extensive anaplastic squamous cell carcinoma involving the nasal cavity and accessory sinuses, an incidence rate of 298 per 100,000. Owing to the Provincial Cancer Service the registration of malignant disease is virtually complete and during 1973 the total Alberta registration of squamous carcinoma of the nasal cavity, accessory sinuses and nasopharynx was 28 cases. Assuming that all 28 cases arose in males over 24 years of age, and knowing that the 1973 Alberta population included 412,000 males over the age of 24 years a maximum expected incidence rate of 6.8 per 100,000 would apply to this population group. This paper describes the two dentists referred to above, contrasts the incidence rates previously quoted, discusses the frequency of malignancy among dentists in general and most especially draws attention to the role of inhaled oil droplets produced by high speed air rotor dental drills as a possible occupational carcinogenic hazard in the dental profession. On reviewing the world medical literature no previous report of this hazard has yet been traced. There is no significant risk for dental patients.
An algorithm for automatic topology discovery of IP networks (2002)

A topology discovery algorithm for IP networks is proposed. Topology configuration information can be obtained from various sources including the MIBs in routers and gateways, the Internet Control Message Protocol (ICMP), the traceroute program, the Domain Name System (DNS), and etc. In order to retrieve the MIB information in a router, the IP address of the router has to be known. However, the IP addresses of the routers in the network of interest may not be known in advance. This paper presents an algorithm for automatic topology discovery under the situation that the IP addresses of the routers are not known in advance. Detailed implementation techniques for bringing pieces of the information together to produce a topology map are discussed.