gebhart/patrepeval huggingface dataset:
Antibody to Silicone and Native Macromolecules in Women with Silicone Breast Implants (1994)

Silicone implants have been associated with the development of multiple organ system abnormalities, including rheumatic disorders, nervous system, pulmonary dysfunction associated with autoantibodies and abnormalities of cellular immunity. In this regards a number of case reports and series of articles have been described. We hypothesized that an immune reaction to silicone breast implants would include the host reactivity against silicone and the macromolecules within the microenvironment of the implant, and these autoantibodies may react with other tissue antigens far from the site of the implant. To test this hypothesis 520 Symptomatic women with Silicone Implants which have developed Silicone related Immunological disorders and have typically complained of breast pain, Myalgia-Arthralgia, fatigue, or generalized pain, were examined by their physician. Blood samples were obtained and examined for the presence of Silicone antibodies, Myelin Basic Protein and human serum albumin antibodies. These samples were then compared to 520 matched controls without implants. At least at the level of two standard deviation silicone specific antibodies, IgG, IgA IgM, IgE and IgG+IgA+IgM antibodies were detected above the mean of normal controls. When these antibodies were classified based on the specialty of the examining physician, the % of patients with Silicone Antibodies were varied; general practice 51.6, Rheumatology 58.7, and Plastic Surgery 83.3, which may relate to the severeness of the disease. Being that a large % of patients demonstrated very high levels of Myelin Basic Protein Antibodies, possible cross reactive antibodies were sought. However, absorption of highly positive sera for Silicone Antibodies with MBP did not change the levels of Silicone Antibodies. On the other hand, Silicone-HSA was able to reduce the antibody values significantly. This reduction in antibody levels by Silicone is the best indication for the specificity of these antibodies. Moreover when data for silicone antibodies and MBP antibodies was analyzed in patients some with high and others with medium or low levels of silicone antibodies, MBP antibodies did not correspond to the silicone antibody levels. Similarly human serum albumin antibodies which was significantly higher in patients with silicone implants did not correlate with levels of silicone antibodies. These results indicate that immune reaction to silicone and different tissue antigens do occur and they are initiated through different mechanisms. And since predominant antibody class against silicone, MBP and HSA was IgM, clonal activation of IgM is possible which certainly warrants further investigation.
Information Theoretic Analysis of LDS Scheme (2011)

In this paper, the capacity region of Low Density Signature Multiple Access Channel (LDS-MAC) is calculated through information theoretic analysis. LDS Code Division Multiple Access (LDS-CDMA) uses spreading sequences of low density for spreading the data symbols in time domain. This technique benefits from a less complex Multiuser Detector (MUD) compared to conventional CDMA with optimum MUD; while keeping the performance close to the single user scenario for up to 200% loaded conditions. Also evaluated is the effect of different factors on the capacity of LDS MAC.
Theoretical Basis for Improvement Following Reduction Pneumoplasty in Emphysema (1997)

Reduction pneumoplasty may improve flow rates, comfort, and exercise tolerance in severe emphysema. The basis for improvement has not been systematically addressed. The major disability of emphysema stems from impairment of maximal expiratory flow-volume performance of the lung (MEFV). This requires the chest wall to operate at high volumes, which in turn severely compromises inspiratory muscle function. Clinical benefit, then, requires that MEFV performance improve so that the operating lung volume is reduced. This study presents theory and illustrative calculations. Removing nonventilating lung (e.g., bullae) simply displaces the MEFV curve down the volume axis. Removing ventilating parenchyma reduces both volume and maximal expiratory flow at iso-lung recoil pressure, and shortens the curve on the volume axis. The critical beneficial effect in both cases is reduction of the volume for a given limiting flow, VL (Vmax). Removing a given fraction of lung from the ventilating compartment is nearly as effective as removing it from the nonventilating compartment. Lowering of operating volumes benefits the strength, efficiency, endurance, and reserve of the inspiratory muscles and thus extends the metabolic scope of the emphysematous patient.
Magnetically Levitated Planar Actuator with Moving Magnets (2007)

This paper concerns the design, optimization and commutation of a six degree-of-freedom planar actuator with active magnetic bearing. The planar motor has a stationary coils array and a translator with a Halbach magnet array. During movements in the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">xy</i> -plane, the set of energized coils changes with the position of the translator. In this paper a method for the electromagnetic design of this type of actuator is discussed and several topologies are compared.
Desingularization of nonredundant serial manipulator trajectories using Puiseux series (1998)

It is shown that smooth spatial paths for nonredundant serial robots can always be smoothly reparametrized in the vicinity of kinematic singularities with finite root multiplicity using a Puiseux series. This reparametrization, based on the algebraic structure of the manipulator kinematics, is formed using the /spl nu/th root of the path parameter distance to the singularity, where /spl nu/ is some integer not exceeding the root multiplicity of the singularity. By contrast, self-motion singularities, which have infinite root multiplicity, do not possess such a reparametrization. However, smooth motions directly through such singularities are generally possible because approaching path solutions are unaffected by them. These results help quantify how joint derivatives blow up at singularities, and can readily be used to generate singularity-robust motions along any path, with no spatial error. This is illustrated with an example involving the PUMA manipulator.
Novel benzothiazolyl urea and thiourea derivatives with potential cytotoxic and antimicrobial activities (2007)

A novel series of benzothiazole urea and thiourea derivatives was synthesized and evaluated for its in vitro cytotoxicity against MCF-7 breast cancer cells. The N1-(benzothiazol-2-yl)-N3-morpholinourea 3 displayed the highest cytotoxic activity in this series. A docked pose of 3 was obtained bound to G-quadruplex of human telomere DNA active site using the Molecular Operating Environment (MOE) module. Moreover, the synthesized compounds were screened for their antimicrobial activity against Mycobacterium tuberculosis H37Rv, E. coli, S. aureus and C. albicans. Again, 3 showed the best activity against M. tuberculosis H37Rv while other compounds were equipotent with ampicillin against S. aureus and E. coli.
Induced Morphological Changes in Synthetic Giant Vesicles: Growth, Fusion, Undulation, Excretion, Wounding, and Healing (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInduced Morphological Changes in Synthetic Giant Vesicles: Growth, Fusion, Undulation, Excretion, Wounding, and HealingF. M. Menger and S. J. LeeCite this: Langmuir 1995, 11, 10, 3685–3689Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/la00010a016https://doi.org/10.1021/la00010a016research-articleACS PublicationsRequest reuse permissionsArticle Views305Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SPINAL µ‐OPIOID RECEPTOR EXPRESSION AND HYPERALGESIA WITH DEXAMETHASONE IN CHRONIC ADJUVANT‐INDUCED ARTHRITIS IN RATS (2008)

1. It is known that inflammation influences peripheral and central mu-opioid receptor expression. Previous studies have indicated that glucocorticoids may influence the density of mu-opioid receptors. In the present study, we investigated the fluctuations of spinal mu-opioid receptor expression and hyperalgesia induced by complete Freund's adjuvant (CFA) under long-term administration of dexamethasone. 2. Adjuvant arthritis (AA) was induced by subcutaneous injection of CFA in the right hindpaw of male Wistar rats. Spinal mu-opioid receptor expression was detected by semiquantitative reverse transcription-polymerase chain reaction on Days 6 and 21 following AA induction. Dexamethasone (0.1 mg/kg) was administered intraperitoneally for 21 days. Variations in thermal hyperalgesia were checked by radiant heat on the same days as mu-opioid receptor expression was determined. 3. The results indicated a significant increase in spinal mu-opioid receptor expression on Days 6 and 21 after AA induction compared with the control group. Spinal mu-opioid receptor expression decreased significantly only on Day 21 in the AA + dexamethasone group compared with the AA alone group. Thermal hyperalgesia on Day 6 after AA induction showed a significant increase compared with the control group. Hyperalgesia decreased significantly on Day 21 after AA compared with Day 6. The AA + dexamethasone group showed a significant decrease in hyperalgesia on Day 6 compared with the AA group, but hyperalgesia increased significantly on Day 21 in the AA + dexamethasone group compared with the AA group. 4. The effects of long-term dexamethasone on both spinal mu-opioid receptor expression and hyperalgesia during persistent AA inflammation are time dependent. In addition, the effect of long-term dexamethasone administration on hyperalgesia during persistent arthritis inflammation needs to be investigated further.
Synthesis of Nitrones Using the Methyltrioxorhenium/Hydrogen Peroxide System (1996)

Secondary amines are oxidized by the methyltrioxorhenium/hydrogen peroxide system to the corresponding nitrones in excellent yield. The results provide a further example of the parallel between the chemistry of this metal system and that of the dioxiranes.
Solid state diode magnetic fluxmeter† (1970)

A design of a solid state diode magnetic fluxmeter utilizing the effect of magnetic Field on its forward current characteristic is reported. Using three suitable diodes, a bridge circuit is constructed for the automatic compensation of the effect of tomperature on the sensitivity of the fluxmeter. A typical fluxmeter constructed in the laboratory is able to measure directly a magnetic field from 2 to 19 kilogauss and its transient response is found to bo much better than those of conventional fluxmetera.
Scuderi Split Cycle Research Engine: Overview, Architecture and Operation (2011)

<div class="section abstract"><div class="htmlview paragraph">The Scuderi engine is a split cycle design that divides the four strokes of a conventional combustion cycle over two paired cylinders, one intake/compression cylinder and one power/exhaust cylinder, connected by a crossover port. This configuration provides potential benefits to the combustion process, as well as presenting some challenges. It also creates the possibility for pneumatic hybridization of the engine. This paper reviews the first Scuderi split cycle research engine, giving an overview of its architecture and operation. It describes how the splitting of gas compression and combustion into two separate cylinders has been simulated and how the results were used to drive the engine architecture together with the design of the main engine systems for air handling, fuel injection, mixing and ignition. A prototype engine was designed, manufactured, and installed in a test cell. The engine was heavily instrumented and initial performance results are presented.</div></div>
Composite Grafts in Facial Reconstructive Surgery (1972)

Composite grafts, when properly used, provide suitable tissues for the repair of certain troublesome facial defects. The following general principles are suggested for the use of composite grafts. No part of the graft should be more than 1 cm away from the edges of the repaired defect. In preparing the recipient site, all local pathology and scar tissue should be removed and complete hemostasis should be obtained. Gentle handling of the graft is mandatory. The graft should be sutured into place by careful plastic technique immediately upon its removal from the donor area. If a dressing is utilized, it must not impair the graft's circulation. Facial structures which have been partially or completely reconstructed with composite grafts Include the nose, ears, eyebrows, lips, and the facial skin with its underlying soft tissue.
Understanding tools: Task-oriented object modeling, learning and recognition (2015)

In this paper, we present a new framework - task-oriented modeling, learning and recognition which aims at understanding the underlying functions, physics and causality in using objects as “tools”. Given a task, such as, cracking a nut or painting a wall, we represent each object, e.g. a hammer or brush, in a generative spatio-temporal representation consisting of four components: i) an affordance basis to be grasped by hand; ii) a functional basis to act on a target object (the nut), iii) the imagined actions with typical motion trajectories; and iv) the underlying physical concepts, e.g. force, pressure, etc. In a learning phase, our algorithm observes only one RGB-D video, in which a rational human picks up one object (i.e. tool) among a number of candidates to accomplish the task. From this example, our algorithm learns the essential physical concepts in the task (e.g. forces in cracking nuts). In an inference phase, our algorithm is given a new set of objects (daily objects or stones), and picks the best choice available together with the inferred affordance basis, functional basis, imagined human actions (sequence of poses), and the expected physical quantity that it will produce. From this new perspective, any objects can be viewed as a hammer or a shovel, and object recognition is not merely memorizing typical appearance examples for each category but reasoning the physical mechanisms in various tasks to achieve generalization.
Rate controls on the oxidation of heaps of pyritic material imposed by upper temperature limits on the bacterially catalysed process (1993)

Oxidation of a fraction of the pyrite in gold-bearing pyrite ores before leaching often increases gold recovery rates. There are a number of techniques availablc, one of which is dump oxidation. Commercial viability of such an operation requires a net oxidation of 50% or more in 1 year. This is possible in a dump provided convection is established quickly. Since convection requires temperatures in the dump to be well above ambient, a question arises as to the constraints that might be imposed by the upper temperature limit (Tkill) of the microorganisms which catalyse the oxidation of the pyrite. Our objective is to investigate, by way of a computer model, the importance of Tkill as a parameter effecting the oxidation rate and the fraction of pyrite oxidised after 1 year in dumps where the goal is to oxidise about 50% of the pyrite in a year or less.
Observation of Resonances in the Radiation Pressure on Dielectric Spheres (1977)

We report an experimental check of the Mie-Debye theory for the variation of radiation pressure on dielectric spheres with wavelength and size using optical-levitation techniques. Sharp resonances are observed which are shown to be related to dielectric surface waves. They permit particle-size measurement to a precision of 1 part in ${10}^{5}$ to ${10}^{6}$.
Noise Performance and SNR Threshold in PFM (1985)

Pulse frequency modulation (PFM) has been considered by several authors for transmitting wide-band signals. However, the noise performance of PFM has been analyzed only above the SNR threshold. In this correspondence the results on the noise performance of PFM available in the literature are summarized, and a more general expression describing noise performance of PFM, both above and below the SNR threshold, is derived. This expression can be used to evaluate the SNR threshold for channels with both signal-independent noise (e.g., metallic facilities) and signal-dependent noise (e.g., fiber optic facilities). In particular, it is shown that in systems with signal-independent white noise, the SNR threshold is approximately 20 dB.
Quantification of Electrophilic Activation by Hydrogen-Bonding Organocatalysts (2014)

A spectrophotometric sensor is described that provides a useful assessment of the LUMO-lowering provided by catalysts in Diels-Alder and Friedel-Crafts reactions. A broad range of 33 hydrogen-bonding catalysts was assessed with the sensor, and the relative rates in the above reactions spanned 5 orders of magnitude as determined via (1)H- and (2)H NMR spectroscopic measurements, respectively. The differences between the maximum wavelength shift of the sensor with and without catalyst (Δλ(max)(-1)) were found to correlate linearly with ln(k(rel)) values for both reactions, even though the substrate feature that interacts with the catalyst differs significantly (ketone vs nitro). The sensor provides an assessment of both the inherent reactivity of a catalyst architecture as well as the sensitivity of the reaction to changes within an architecture. In contrast, catalyst pK(a) values are a poor measure of reactivity, although correlations have been identified within catalyst classes.
A study of malignant tumours in Nigeria by short-term tissue culture (1965)

<h3>Objective</h3> The main objectives of this study were to synthesise and compare pandemic preparedness strategies issued by the federal and provincial/territorial (P/T) governments in Canada and to assess whether COVID-19 public health (PH) measures were tailored towards priority populations, as defined by relevant social determinants of health. <h3>Methods</h3> This scoping review searched federal and P/T websites on daily COVID-19 pandemic preparedness strategies between 30 January and 30 April 2020. The PROGRESS-Plus equity-lens framework was used to define priority populations. All definitions, policies and guidelines of PH strategies implemented by the federal and P/T governments to reduce risk of SARS-CoV-2 transmission were included. PH measures were classified using a modified Public Health Agency of Canada Framework for Canadian Pandemic Influenza Preparedness. <h3>Results</h3> A total of 722 COVID-19 PH measures were issued during the study period. Of these, home quarantine (voluntary) (n=13.0%; 94/722) and retail/commerce restrictions (10.9%; n=79/722) were the most common measures introduced. Many of the PH orders, including physical distancing, cancellation of mass gatherings, school closures or retail/commerce restrictions began to be introduced after 11 March 2020. Lifting of some of the PH orders in phases to reopen the economy began in April 2020 (6.5%; n=47/722). The majority (68%, n=491/722) of COVID-19 PH announcements were deemed mandatory, while 32% (n=231/722) were recommendations. Several PH measures (28.0%, n=202/722) targeted a variety of groups at risk of socially produced health inequalities, such as age, religion, occupation and migration status. <h3>Conclusions</h3> Most PH measures centred on limiting contact between people who were not from the same household. PH measures were evolutionary in nature, reflecting new evidence that emerged throughout the pandemic. Although ~30% of all implemented COVID-19 PH measures were tailored towards priority groups, there were still unintended consequences on these populations.
Low-Temperature Transportable Technology for On-Site Remediation (1992)

An innovative technology, the Low Temperature Thermal Treatment (LT3) System was developed by Roy F. Weston, Inc. to treat soils, sludges and sediments contaminated with volatile and semivolatile organic compounds. The LT3 process was utilized to remediate a contaminated site near Crows Landing, CA. The processed soil was treated to less than 5 ppm of total petroleum hydrocarbons. During operation stack emissions were analyzed to determine emission characteristics.
Multimode optical fiber splice loss: Relating system and laboratory measurements (1987)

We examine the splice loss occurring along a multimode fiber regenerator span and compare the results to a "standard" laboratory test condition. Large variations in the splice loss sensitivity to transverse offset of a "reference" splice were seen 1) at the ends of 5 different 8.9-km fiber concatenations and 2) at various locations along one 8.9-km path. These data indicate that significant variations in the modal power distribution exist even at the receiver end of a regenerator span. This is explained by the long coupling lengths (long compared to splice spacing) of low loss fibers and the random amount of mode coupling introduced by the concatenation splices. Splice loss measurements made with an "overfilled" launch condition and a 3-turn 20-mm mandrel wrap mode filter (commonly used in fiber loss measurements) accurately approximated the average splice loss sensitivity along the span for offsets less than 4 μm. i.e., losses less than 0.2 dB. For offsets greater than 4 μm, the mandrel wrap mode filter configuration yields a pessimistic estimate, but is within 30 percent of the average "system" loss for most cases of interest. This demonstrates the usefulness of the mode filter in establishing splice measurement conditions that yield results representative of those seen in a regenerator span.
Enhancement of Thermoelectric Efficiency in PbTe by Distortion of the Electronic Density of States (2008)

The efficiency of thermoelectric energy converters is limited by the material thermoelectric figure of merit (zT). The recent advances in zT based on nanostructures limiting the phonon heat conduction is nearing a fundamental limit: The thermal conductivity cannot be reduced below the amorphous limit. We explored enhancing the Seebeck coefficient through a distortion of the electronic density of states and report a successful implementation through the use of the thallium impurity levels in lead telluride (PbTe). Such band structure engineering results in a doubling of zT in p-type PbTe to above 1.5 at 773 kelvin. Use of this new physical principle in conjunction with nanostructuring to lower the thermal conductivity could further enhance zT and enable more widespread use of thermoelectric systems.