gebhart/patrepeval huggingface dataset:
Extra cardiac findings by 64-multidetector computed tomography in patients with symptomatic atrial fibrillation prior to pulmonal vein isolation (2010)

The aim of this study was to investigate the prevalence of extracardiac findings diagnosed by 64-multidetector computed tomography (MDCT) examinations prior to circumferential pulmonary vein (PV) ablation of atrial fibrillation (AF). A total of 158 patients (median age, 60.5 years; male 68%) underwent 64-MDCT of the chest and upper abdomen to characterize left atrial and PV anatomy prior to AF ablation. MDCT images were evaluated by a thoracic radiologist and a cardiologist. For additional scan interpretation, bone, lung, and soft tissue window settings were used. CT scans with extra-cardiac abnormalities categorized for the anatomic distribution and divided into two groups: Group 1-exhibiting clinically significant or potentially significant findings, and Group 2-patients with clinically non-significant findings. Extracardiac findings (n = 198) were observed in 113/158 (72%) patients. At least one significant finding was noted in 49/158 patients (31%). Group 1 abnormalities, such as malignancies or pneumonias, were found in 85/198 findings (43%). Group 2 findings, for example mild degenerative spine disease or pleural thickening, were observed in 113/198 findings (72%). 74/198 Extracardiac findings were located in the lung (37%), 35/198 in the mediastinum (18%), 8/198 into the liver (4%) and 81/198 were in other organs (41). There is an appreciable prevalence of prior undiagnosed extracardiac findings detected in patients with AF prior to PV-Isolation by MDCT. Clinically significant or potentially significant findings can be expected in ~40% of patients who undergo cardiac MDCT. Interdisciplinary trained personnel is required to identify and interpret both cardiac and extra cardiac findings.
Differential Privacy for Statistics: What we Know and What we Want to Learn (2010)

We motivate and review the definition of differential privacy, survey some results on differentially private statistical estimators, and outline a research agenda. This survey is based on two presentations given by the authors at an NCHS/CDC sponsored workshop on data privacy in May 2008.
Functionalization at the double-bond region of jojoba oil. 3. Hydroxylic derivatives (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFunctionalization at the double-bond region of jojoba oil. 3. Hydroxylic derivativesArnon ShaniCite this: Ind. Eng. Chem. Prod. Res. Dev. 1983, 22, 1, 121–123Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/i300009a027https://doi.org/10.1021/i300009a027research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Integrated Pre-Well Planning Process Improves Service Quality and Decreases Risk through Cooperation between Drilling and Geosciences (2011)

Abstract Drilling complex wells with minimum risk and optimizing well placement with the least possible cost are key goals that oil companies strive to achieve. Service companies and operators apply several pre-well planning processes and methods to enhance drilling operations effectively and attain objectives. One of these processes involves a thorough understanding and application of the geological structure, not only within the reservoir section, but also in the over-burden where typically most of the time efficiency gains can be achieved. This can be best accomplished by fostering intense and effective communication between all stakeholders. In this paper, the authors present the latest integrated pre-well planning (IPWP) process that defines a methodology for conducting a formal planning, a process incorporating all aspects of drilling, well design, formation evaluation, bit selection and bottom hole assembly proposal. It also lists key considerations required in planning, coordination, and successful implementation of these services on the customer’s well with a means to assess potential technical risks that may influence the success of the job. The paper also describes a complex water injection well drilled in a Middle East onshore field where the integrated pre-well-planning process played a significant part in successfully achieving the aim of this challenging job.
Mobile Code Security Techniques (1998)

This paper presents a survey of existing techniques for achieving mobile code security, as well as a representative sampling of systems which use them. In particular, the problem domain is divided into two portions: protecting hosts from malicious code; and protecting mobile code from malicious hosts. The discussion of the malicious code problem includes a more in-depth study of the Java security model, as well as touching upon several other systems. The malicious host problem, however, is much more difficult to solve, so our discussion is mostly restricted to ongoing research in that area. 1 Introduction The recent explosion of the Internet, and in particular, the World Wide Web, offers an astounding amount of interconnected computing resources. However, for most users, their use of Internet resources is primarily limited by bandwidth. In particular, especially in home computers, there are many CPU cycles to spare in comparison to the rate at which data can be retrieved. This suggest...
Advanced coupling matrix synthesis techniques for microwave filters (2003)

A general method is presented for the synthesis of the folded-configuration coupling matrix for Chebyshev or other filtering functions of the most general kind, including the fully canonical case, i.e., N prescribed finite-position transmission zeros in an Nth-degree network. The method is based on the "N+2" transversal network coupling matrix, which is able to accommodate multiple input/output couplings, as well as the direct source-load coupling needed for the fully canonical cases. Firstly, the direct method for building up the coupling matrix for the transversal network is described. A simple non-optimization process is then outlined for the conversion of the transversal matrix to the equivalent "N+2" folded-configuration coupling matrix. The folded matrix may be used directly to realize microwave bandpass filters in a variety of technologies, but some of these could require awkward-to-realize cross-couplings. This paper concludes with a description of two simple procedures for transforming the transversal and folded matrices into two novel network configurations, which enable the realization of advanced microwave bandpass filters without the need for complex inter-resonator coupling elements.
Inhibition of specific binding of [<sup>3</sup>H]phorbol-12,13-dipropionate to an epidermal fraction by certain irritants and irritant promoters of mouse skin (1983)

Specific binding of [3H]phorbol-12,13-dipropionate ([3H]PDPr) to a particulate fraction of mouse skin is demonstrated (KD = 35 nM; Rt = 1.2 pmol/mg protein). A series of compounds of the diterpene ester, indole akaloid and polyacetate types with different degrees of activity as skin tumor promoters and/or irritants have been tested for their capacity to inhibit specific [3H]PDPr binding. Three main categories are found: (i) compounds which exhibit a positive correlation between their potency as irritants and promoters in vivo and their inhibition of specific binding in vitro: 12-O-tetradecanoylphorbol-13-acetate, 3-O-tetradecanoylingenol, pimelea factor P2, 'teleocidin', dihydroteleocidin B, and lyngbyatoxin are active in vivo and in vitro, whereas phorbol and ingenol are inactive and 4-O-methyl-12-O-tetradecanoyl-phorbol-13-acetate is weakly active; (ii) compounds which are strong irritants and inhibitors of binding but are weak or practically non-promoters: mezerein, 12-O-retinoylphorbol-13-acetate and milliamine C; (iii) strong irritants which are weak or marginally active inhibitors of binding: debromoaplysiatoxin and resiniferatoxin. Some consequences of these findings with respect to interpretations of the biochemical mechanism(s) of tumor promotion are discussed.
Rapid detection of Streptococcus pyogenes in pediatric patient specimens by DNA probe (1993)

A chemiluminescent DNA probe test (Group A Streptococcus Direct Test; Gen-Probe, Inc., San Diego, Calif.) for rapid, direct detection of cRNA of Streptococcus pyogenes in throat swabs was compared with conventional culture and identification techniques. Throat swabs from 277 patients suspected of having streptococcal pharyngitis were examined. By DNA probe alone, 10 specimens were positive, 51 were positive by both assays, and 8 were positive by culture alone. Thus, DNA probe sensitivity, specificity, and positive and negative predictive values were 86, 95, 84, and 96%, respectively. Including an indeterminate category, sensitivity, specificity, and positive and negative predictive values were 89, 96, 86, and 97%, respectively. After discrepancy testing, these values for the raw data improved to 90, 98, 93, and 97%, respectively. None of the 24 specimens that grew non-S. pyogenes beta-hemolytic streptococci in culture were positive by the DNA probe. Because mucoid S. pyogenes strains are more virulent than nonmucoid strains, 24 isolates were retrospectively tested with the DNA probe to ensure that both types would be detected equally well. Isolates were examined in pure cultures as well as mixed with representative normal oral flora. There was no statistical difference in detection of any of the four groups. Group A Streptococcus Direct Test is a rapid, sensitive, and specific test for S. pyogenes.
Syntheses and structures of 3,7‐substituted barbaralanes (1995)

Abstract Short and efficient syntheses of the barbaralanes 2e‐h are reported. Meerwein's diketone 9 is converted into the bis(vinyl sulphide) 10 by the action of 4‐chlorothiophenol in the presence of titanium(IV) chloride and triethylamine. Oxidation of 10 with sodium perborate in acetic acid affords the bis(vinyl sulphone) 11 which is treated with potassium cyanide supported on aluminium oxide to yield the unsaturated dinitrile 8. Bromination of 8 with N ‐bromosuccinimide and subsequent reductive cyclisation of the resulting exo,exo dibromodinitrile 13 with the zinc‐copper couple furnish 3,7‐dicyanobarbaralane ( 2e ) in 53% overall yield based on 9. – Treatment of dinitrile 8 with hydrochloric acid in boiling methanol followed by hydrolysis of the intermediate Pinner salt yields the dimethyl dicarboxylate 14 which is brominated to afford the exo,exo dibromo diester 15. Reductive cyclisation of 15 gives rise to the formation of dimethyl 3,7‐barbaralanedicarboxylate ( 2f ) in 49% overall yield based on 9. – Bicyclo[3.3.1]nonane‐3,7‐dione ( 7 ) is converted into a mixture of the bis(vinyl sulphones) C 2 ‐ and C s ‐ 17 (1:1) as described for 9 → 11. Bromination of this mixture yields a single exo,exo dibromo compound 18 which is cyclised by the zinccopper couple to afford 3,7‐bis(phenylsulphonyl)barbaralane ( 2g ) in 56% overall yield based on 7. – The known phenyl‐2‐oxaadamantanol 21a is cleaved by the action of boron trifluoride and acetic anhydride to yield the bicyclo[3.3.1]none‐none 22. The difluoroboron complex 23 is obtained under more rigorous conditions. Addition of phenylcerium(III) chloride to 22 followed by dehydration of the endo alcohol 24 yields the diphenyldiene 25. Bromination of 25 and subsequent reductive cyclisation of the exo,exo dibromodiphenyldiene 26 furnish 3,7‐diphenylbarbaralane ( 2h ) which is isolated by preparative reversed‐phase chromatography in 50% overall yield based on 7. – The configurations and conformations in the crystals are elucidated by X‐ray diffraction analyses for the bicyclo[3.3.1]nonane derivatives 7, 13, 15, 18, 22–24 , and 26 and the barbaralanes 2e‐g. In the solid state, 2e and f exist as pairs of rapidly rearranging nonequivalent valence tautomers while the atomic distances observed for 2g indicate the presence of a single nonrearranging valence tautomer.
Tromp1, a putative rare outer membrane protein, is anchored by an uncleaved signal sequence to the Treponema pallidum cytoplasmic membrane (1997)

Treponema pallidum rare outer membrane protein 1 (Tromp1) has extensive sequence homology with substrate-binding proteins of ATP-binding cassette transporters. Because such proteins typically are periplasmic or cytoplasmic membrane associated, experiments were conducted to clarify Tromp1's physicochemical properties and cellular location in T. pallidum. Comparison of the sodium dodecyl sulfate-polyacrylamide gel electrophoresis mobilities of (i) native Tromp1 and Tromp1 synthesized by coupled in vitro transcription-translation and (ii) native Tromp1 and recombinant Tromp1 lacking the N-terminal signal sequence revealed that the native protein is not processed. Other studies demonstrated that recombinant Tromp1 lacks three basic porin-like properties: (i) the ability to form aqueous channels in liposomes which permit the influx of small hydrophilic solutes, (ii) an extensive beta-sheet secondary structure, and (iii) amphiphilicity. Subsurface localization of native Tromp1 was demonstrated by immunofluorescence analysis of treponemes encapsulated in gel microdroplets, while opsonization assays failed to detect surface-exposed Tromp1. Incubation of motile treponemes with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)-diazarine, a photoactivatable, lipophilic probe, also did not result in the detection of Tromp1 within the outer membranes of intact treponemes but, instead, resulted in the labeling of a basic 30.5-kDa presumptive outer membrane protein. Finally, analysis of fractionated treponemes revealed that native Tromp1 is associated predominantly with cell cylinders. These findings comprise a body of evidence that Tromp1 actually is anchored by an uncleaved signal sequence to the periplasmic face of the T. pallidum cytoplasmic membrane, where it likely subserves a transport-related function.
Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. (2003)

Recent studies have shown that several loss-of-function mouse models of prostate carcinogenesis can develop a spectrum of precancerous lesions that resemble human prostatic intraepithelial neoplasia (PIN). Here, we have investigated the malignant potential of the high-grade PIN lesions that form in Nkx3.1(+/-); Pten(+/-) compound mutant mice and demonstrate their neoplastic progression in a serial transplantation/tissue recombination assay. Furthermore, we find that a majority of Nkx3.1(+/-); Pten(+/-) mice greater than 1 year of age develop invasive adenocarcinoma, which is frequently accompanied by metastases to lymph nodes. Finally, we observe androgen independence of high-grade PIN lesions after androgen ablation of Nkx3.1(+/-); Pten(+/-) mice. We conclude that Nkx3.1(+/-); Pten(+/-) mice recapitulate key features of advanced prostate cancer and represent a useful model for investigating associated molecular mechanisms and for evaluating therapeutic approaches.
Bacterial endocarditis following repeated tattooing (2001)

Body decoration in the form of tattooing is becoming increasingly popular, especially among younger age groups. Although serious infections following tattooing are rare they are well documented. The first reported case of endocarditis caused by repeated tattooing in an individual with known valvar heart disease is presented.
Realistic model of LED structure with InGaN quantum-dots active region (2015)

We report on numerical simulations of quantum-dot heterostructures derived from experimental high-resolution transmission electron microscopy results. A real sample containing large InGaN islands with size of ten of nm and non-uniform In content is analyzed. The three-dimensional models for the quantum dots have been directly extrapolated from experimental results by a numerical algorithm. We show electromechanical, continuum k→ · p→, empirical tight-binding and optical calculations for these realistic structures, which present a very good agreement if compared with experimental measurements, implying that the use of realistic structures can provide significant improvements into the modeling and the understanding of quantum-dot nanostructures.
Arsenic(III) and Arsenic(V) Removal from Solutions by Pyrite Fines (1993)

Abstract An investigation on the effective removal of arsenic anions existing in both main valency states, i.e., as As(III) and As(V), from dilute aqueous solutions by the addition of pyrite fine particles was conducted in the laboratory (bench-scale experiments). Pyrite constitutes an industrial by-product/solid waste in mixed sulfides processing plants. This paper examines an unconventional application of pyrite as an adsorbent of arsenic ions. The results were evaluated by electrokinetic studies and stability data.
Hearing, Remembering, Cold Storage, Purism, Evidence, and Attitude Adjustment (1996)

What does it mean for the celebrated D#s in the first movement of Beethoven's Violin Concerto to "stay in one's ear" during the time between their initial unresolved occurrence and their eventual resolution? What is it to hear such a thing? Or is the relevant experience not to be described as an auditory one? Supposing that an account of an auditory experience can be given (one is offered), what if it is of such a nature as to seem unsuited to generalization? Then, presumably, occasion will have been found to countenance a music-theoretical posit without consistent auditory significance. Is this acceptable? To what conception of music theory might it be most congenial?
Human Infrapatellar Fat Pad-Derived Stromal Cells have more Potent Differentiation Capacity than other Mesenchymal Cells and can be Enhanced by Hyaluronan (2014)

The microenvironment plays an important role in the homing in and differentiation of stem cells to repair injured tissue. Infrapatellar fat pad stromal cells (IFPSCs) are a promising source of such cells for the repair of articular injury-induced degeneration. This study investigated the chemotaxis of IFPSCs to chondrocytes and the effect of hyaluronan (HA) on the biological and regenerative properties of IFPSCs. The IFPSCs were obtained from patients undergoing arthroscopy and cultured via a standard 2-week culture protocol that yielded more than 10 million cells on passage 3. The results showed that the IFPSCs had a higher capacity for chondrogenic differentiation than mesenchymal cells from body fat, bone marrow, and Wharton's jelly of the umbilical cord. The IFPSCs cultured on 25% or 50% HA showed better osteogenic and adipogenic capabilities than those without HA or with 75% HA (p < 0.001). Cultures of the IFPSCs on 25% HA had a fourfold increase in chondrogenic differentiation compared to cultures without HA, which was better than with 50% and 75% HA (p < 0.05). Cell proliferation was not affected by the presence of HA. In conclusion, IFPSCs have a strong potential for chondrogenic regeneration, which can even be augmented in a 25% HA microenvironment.
Shortest path ray tracing with sparse graphs (1993)

Abstract A technique for improving the efficiency of shortest path ray tracing (SPR) is presented. We analyze situations where SPR fails and provide quantitative measures to assess the performance of SPR ray tracing with varying numbers of nodes. Our improvements include perturbing the ray at interfaces according to Snell's Law, and a method to find correct rays efficiently in regions of low velocity contrast. This approach allows the investigator to use fewer nodes in the calculation, thereby increasing the computational efficiency. In two-dimensional (2-D) cross-borehole experiments we find that with our improvements, we need only use 2/3 as many nodes, saving up to 60 percent in time. Savings should be even greater in three dimensions. These improvements make SPR more attractive for tomographic applications in three dimensions.
Improved Power for Characterizing Longitudinal Amyloid-β PET Changes and Evaluating Amyloid-Modifying Treatments with a Cerebral White Matter Reference Region (2015)

A cerebral white matter reference region may improve the power to track longitudinal fibrillar Aβ increases, to characterize their relationship to longitudinal clinical declines, and to evaluate Aβ-modifying treatments in randomized clinical trials.
5-azacytidine in acute leukemia (1978)

101 patients with acute leukemia in relapse were treated with 5-azacytidine according to three schedules: Regimen A--300 mg/m2(day divided intravenously at 8 hour intervals for 5 days; Regimen B--750 mg/m2 as a single iv pulse dose administered at 2 to 3 weeks intervals; and Regimen C--300 mg/m2/day by continuous infusion daily for 5 days. Twelve patients achieved a complete remission (CR) and six achieved a partial remission (PR) for an overall 18% response rate. Of 78 patients receiving an adequate trial the response rate was 23%. An average of 1.5 courses and a median of 5 weeks were necessary to achieve a response. The median duration of CR patients was 21 weeks and for PR patients it was 5 weeks. Response rates were 24% for Regimen A, 0 for Regimen B, and 1 of 8 for Regimen C. The CR rate for AML and AMML was 13%. Two of eight AMoL patients achieved a CR. Only 2 of 23 ALL patients responded, one of whom achieved a CR. Toxicity included moderate to severe nausea and vomiting, diarrhea, stomatitis, skin rash, and prolonged myelosuppression. 5-azacytidine has significant activity in the acute nonlymphoblastic leukemias.
Catalysis of Pd(II)-Catalyzed Acetalization of Alkenes with Diols (1990)

Abstract Alkenes bearing electron-withdrawing substituents are catalytically acetalized with 1,3-propanediol only by the use of PdCl2(MeCN)2 catalyst under O2 atmosphere. When a combination of BiCl3 and LiCl is used as co-catalyst, the acetalization proceeds effectively. These results indicate that a hydroperoxopalladium(II) species is most likely an active catalyst in the present reaction.
MicroRNA-221 regulates FAS-induced fulminant liver failure (2011)

We identified miR-221 as a potent posttranscriptional regulator of FAS-induced apoptosis. miR-221 may serve as a potential therapeutic target for the treatment of hepatitis and liver failure.
Reducing fuel consumption (1981)

Energy conservation in transport begins with selection of a specific vehicle to perform a specific task and carries on through the manner in which the driver extracts performance from the vehicle, the efficiency of the system under which the vehicle is maintained, and the care with which it is loaded (a).