gebhart/patrepeval huggingface dataset:
Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells (1998)

We examined the mechanism of action of lysophosphatidylcholine (LPC), which is suggested to be involved in the pathogenesis of atherosclerosis and inflammatory disorders, in HL-60 leukaemia cells. Extracellular 1-palmitoyl LPC increased the intracellular Ca2+ concentration in association with production of inositol phosphate. These actions of LPC were markedly inhibited by treatment of the cells with pertussis toxin and U73122, a phospholipase C inhibitor. The lipid-induced stimulation of the phospholipase C/Ca2+ system was also attenuated in the dibutyryl cAMP-induced differentiated (neutrophil-like) cells, in which phospholipase C activation induced by NaF or formyl-Met-Leu-Phe was enhanced. In contrast with the stimulatory action of 1-palmitoyl LPC, 1-stearoyl LPC was inhibitory for the phospholipase C/Ca2+ system stimulated by NaF as well as by 1-palmitoyl LPC or other Ca2+-mobilizing agonists. In a cell-free system, only an inhibitory effect on phospholipase C activity was observed even by 1-palmitoyl LPC; 1-stearoyl LPC was more inhibitive than 1-palmitoyl LPC. Taken together, these results suggest that atherogenic and inflammatory LPC exerts both stimulatory and inhibitory actions on the phospholipase C/Ca2+ system depending on the species of fatty acid residue of the lipid; the stimulatory effect is possibly mediated through G-protein-coupled receptors; the inhibitory effect might be caused by dysfunction of the components involved in the enzyme system owing to the amphiphilic nature of the lipid. 1-Palmitoyl LPC prefers the former receptor stimulation at least in intact cells, but 1-stearoyl LPC preferentially exerts the latter inhibitory action.
Chemoprotection against cyclophosphamide-induced urotoxicity: ribose-cysteine. (1994)

2(R,S)-D-ribo-(1',2',3',4'-tetrahydroxybutyl) thiazolidine-4(R)-carboxylic acid (RibCys) is a prodrug of L-cysteine, which can facilitate the detoxication of numerous substances either directly or by providing the limiting amino acid for the biosynthesis of glutathione (GSH). RibCys was studied for its chemoprotective activity against the potent urotoxicity associated with the common anticancer agent, cyclophosphamide (CTX). In Swiss-Webster mice, RibCys given between 30 min before the toxin to 30 min after, either in a single or a split dose, exhibited powerful ability to protect against CTX-induced bladder inflammation and GSH depletion.
An integrated pressure and temperature sensor based on nanocrystalline porous silicon (2006)

A novel integrated pressure and temperature sensor based on nanocrystalline porous silicon is reported here with a view to develop a smart pressure sensor. A twin MEMS porous silicon/silicon heterojunction structure is designed, fabricated and tested for the integrated pressure and temperature sensor. Pressure and temperature sensitivities have been studied at different porosities of the porous silicon membrane. The optimized porosity is observed to be around 55% for which the pressure sensitivity is about three times and temperature sensitivity is comparable to that of other types of integrated silicon sensors. The design of the integrated sensor has been done by maintaining isotherm characteristics of pressure and temperature sensors and eliminating the cross-coupling effect at the same time.
Atom tracking for reproducible force spectroscopy at room temperature with non-contact atomic force microscopy (2005)

A method for reproducible site-specific force spectroscopic measurements at room temperature by combining frequency modulation atomic force microscopy and the atom tracking technique is proposed. The atom tracking enables us to compensate the change in the tip–sample relative position induced by the thermal drift as well as to precisely position the tip over the same spot of the surface within sub-Angstrom stability. Here, we describe our atom-tracking implementation and the protocol we have followed for the reproducible room-temperature acquisition of series of frequency shift versus tip–sample distance (Δf–Z) curves using this technique. With this acquisition protocol, a large number of equivalent Δf–Z curves can be averaged, resulting in a considerable noise reduction, and therefore avoiding its propagation to the corresponding calculated force curve.
Localization and function of the connexin 43 gap-junction protein in normal and various oncogene-expressing rat liver epithelial cells (1996)

Clones of rat liver epithelial cells genotypically altered by mutation or by a variety of oncogenes were analyzed by microinjection-dye transfer, immunofluorescence confocal microscopy, and western blotting to determine at what level and to what degree these transformations disrupted gap-junctional intercellular communication (GJIC) mediated by connexin 43 (Cx43). Compared with normal rat liver epithelial cells, cells neoplastically transformed by src, neu, ras, and myc/ras all displayed reduced degrees of GJIC, reduced levels of membrane-associated Cx43 plaques, and hypophosphorylation of Cx43. Confocal analysis further demonstrated that the Cx43 protein was localized, at least in part, to the nucleus rather than to the plasma membrane in the src- and neu-transformed cells, but not in the ras- and myc/ras-transformed cells. Nuclei isolated from WB-neu cells showed substantially higher levels of Cx43 on western blotting than did nuclei from WB-neo control cells, supporting the idea that the nuclear-localized immunopositive material detected by confocal microscopy was Cx43 protein. In a GJIC-deficient mutant rat liver epithelial cell line containing normal numbers of plasma membrane-localized Cx43 plaques that appeared to be reduced in size, the Cx43 protein was also found to be hypophosphorylated. Cells overexpressing myc, on the other hand, displayed a normal degree of GJIC, increased levels of plasma membrane-localized Cx43 plaques, and hyperphosphorylation of the Cx43 protein. Cells expressing raf, previously shown to be GJIC competent, showed Cx43 immunostaining patterns similar to those in normal cells, whereas a cell line established from a tumor induced by injection of these raf-expressing cells into a mouse showed a marked reduction in GJIC and plasma membrane-associated Cx43 immunostaining. These data suggest that altered localization of the gap-junction protein Cx43, mediated in part by changes in the phosphorylation of this protein, contributes to the disruption of GJIC in neoplastically transformed rat liver epithelial cells.
In-wheel vehicle control implementation with energy and safety considerations (2016)

The paper deals with the energy optimal and reconfigurable control of a four-wheel independently-actuated (4WIA) vehicle operated by in-wheel hub motors and a steer-by-wire steering system mounted on the front axle.In the proposed setup the vehicle maneuvers around corners by using the powerful torque vectoring capability of the electric in-wheel motors, while steering is only applied when a fault event of a hub motor is detected or the cornering resistance of the vehicle can be reduced by it.The steering intervention is realized by a high-level control reconfiguration based on the LPV (Linear Parameter Varying) method.The operation of the introduced method is tested in CarSim simulation environment.
Big Effects from Small Changes: Possible Ways to Explore Nature's Chemical Diversity (2002)

Fungi or bacteria that produce secondary metabolites often have the potential to bring up various compounds from a single strain. The molecular basis for this well-known observation was confirmed in the last few years by several sequencing projects of different microorganisms. Besides well-known examples about induction of a selected biosynthesis (for example, by high- or low-phosphate cultivation media), no overview about the potential in this field for finding natural products was given. We have investigated the systematic alteration of easily accessible cultivation parameters (for example, media composition, aeration, culture vessel, addition of enzyme inhibitors) in order to increase the number of secondary metabolites available from one microbial source. We termed this way of revealing nature's chemical diversity the 'OSMAC (One Strain-Many Compounds) approach' and by using it we were able to isolate up to 20 different metabolites in yields up to 2.6 g L(-1) from a single organism. These compounds cover nearly all major natural product families, and in some cases the high production titer opens new possibilities for semisynthetic methods to enhance even more the chemical diversity of selected compounds. The OSMAC approach offers a good alternative to industrial high-throughput screening that focuses on the active principle in a distinct bioassay. In consequence, the detection of additional compounds that might be of interest as lead structures in further bioassays is impossible and clearly demonstrates the deficiency of the industrial procedure. Furthermore, our approach seems to be a useful tool to detect those metabolites that are postulated to be the final products of an amazing number of typical secondary metabolite gene clusters identified in several microorganisms. If one assumes a (more or less) defined reservoir of genetic possibilities for several biosynthetic pathways in one strain that is used for a highly flexible production of secondary metabolites depending on the environment, the OSMAC approach might give more insight into the role of secondary metabolism in the microbial community or during the evolution of life itself.
Diversifying the image retrieval results (2006)

In the area of image retrieval, post-retrieval processing is often used to refine the retrieval results to better satisfy users' requirements. Previous methods mainly focus on presenting users with relevant results. However, in most cases, users cannot clearly present their requirements by several query words. Therefore, relevant results with rich topic coverage are more likely to meet users' ambiguous needs. In this paper, a re-ranking method based on topic richness analysis is proposed to enrich topic coverage in retrieval results. Furthermore, a quantitative criterion called diversity scores (DS) is proposed to evaluate the improvement. Given a set of images, topics that are rarely included in the set are scarce topics, as oppose to rich topics that are widely distributed among the set. Scarce topics contribute more than rich topics do to the DS of images. Five researchers are invited to evaluate the re-ranked results both in topic coverage and relevance. Experimental results on over 20,000 images demonstrate that our proposed approach is effective in improving the topic coverage of retrieval results without loss of relevance.
[Stereochemistry of proton catalyzed dimerization of 3-alkyl-indoles]. (1999)

Two dimers (I and II) having 3,3'-disubstituted 2-(2'-indolil)-indoline skeleton were prepared by trifluoroacaetic acid treatment of N-acetyl-L-tryptophan methyl ester. Their CD spectra suggest enantiomeric configuration in 2- and 3-positions of indoline ring. The (-)-enantiomer of skatole dimer has nearly the same CD spectrum as the dimer I. X-ray crystal structure determination of (-)-skatole dimer shows, that it has 2S,3S-trans configuration in the indoline ring suggesting the same configuration of dimer I and opposite, 2R,3R-trans configuration of dimer II.
CO2/CH4 Mixed Gas Separation Using Carbon Hollow Fiber Membranes (2013)

In this study, the permeation properties of single and binary CO2/CH4 mixture were investigated using a module of carbon hollow fiber membranes derived from sulfonated poly(phenylene oxide) (SPPO). SPPO carbon membrane module had a sharp pore-size distribution in the range of 0.35-0.4 nm, and showed high CO2/CH4 ideal selectivity for both single and binary gas separation. The effects of permeation temperature, total feed pressure and CO2 concentration in the feed on separation performances of the carbon membrane module were also investigated. It was found that the CO2/CH4 ideal selectivity decreased slightly with the increasing permeation temperature, total feed pressure, and CO2 concentration in the feed.
Importance of some lactones and 2,5-dimethyl-4-hydroxy-3(2H)-furanone to mango (Mangifera indica L.) aroma (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImportance of some lactones and 2,5-dimethyl-4-hydroxy-3(2H)-furanone to mango (Mangifera indica L.) aromaCharles W. Wilson III, Philip E. Shaw, and Robert J. Knight Jr.Cite this: J. Agric. Food Chem. 1990, 38, 7, 1556–1559Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/jf00097a028https://doi.org/10.1021/jf00097a028research-articleACS PublicationsRequest reuse permissionsArticle Views393Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimized Model Predictive Control of Commercial BTX Plant using Profit� Controller (2006)

This paper presents the results of a model predictive control project using Honeywell's Profitreg Controller RMPCT Technology on a BTX (benzene, toluene and xylene) plant at the LG Petrochemical Co., Ltd. located in Yeosu, Korea. Post-project performance analysis shows the extractor production has been increased. The application of Honeywell's robust multivariable predictive control technology (RMPCT) is proper for the BTX plant due to the present of multiple recycle loops, long process delay and the variation of plant constraint due to the weather condition
Thiol-Capped Germanium Nanocrystals: Preparation and Evidence for Quantum Size Effects (2014)

Applications of Ge nanocrystals (NCs) are limited by the stability and air reactivity of the Ge surface. In order to promote stability and increase the diversity of ligand functionalization of Ge NCs, the preparation of thiol-passivated Ge NCs via a ligand exchange process was investigated. Herein a successful replacement of oleylamine ligands on the surface of Ge NCs with dodecanethiol is reported. The successful ligand exchange was monitored by FTIR and NMR spectroscopy and it was found that dodecanethiol provided a better surface coverage, leading to stable Ge NC dispersions. Dodecanethiol capping also enabled band gap determination of the NCs by surface photovoltage (SPV) spectroscopy. The SPV measurements indicated an efficient charge separation in the ligand-exchanged Ge NCs. On the other hand, oleylamine-terminated Ge NCs of similar sizes exhibited a very small photovoltage, indicating a poorly passivated surface.
Synthesis of endo-Cp2TaH2(BO2C6H4) and exo-Cp2TaH2(BO2C6H4): Regioisomers of the First Tantalum Boryl Complexes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of endo-Cp2TaH2(BO2C6H4) and exo-Cp2TaH2(BO2C6H4): Regioisomers of the First Tantalum Boryl ComplexesDean R. Lantero, Douglas H. Motry, Donald L. Ward, and Milton R. Smith IIICite this: J. Am. Chem. Soc. 1994, 116, 23, 10811–10812Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/ja00102a067https://doi.org/10.1021/ja00102a067research-articleACS PublicationsRequest reuse permissionsArticle Views219Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Nonopsonic phagocytosis of strains of Pseudomonas aeruginosa from cystic fibrosis patients (1984)

Pseudomonas aeruginosa is the predominant respiratory pathogen in patients with cystic fibrosis, but its mechanism of persisting in pulmonary secretions is poorly understood. We observed that three nonmucoid cystic fibrosis P. aeruginosa strains were phagocytized and one strain resisted phagocytosis by human polymorphonuclear leukocytes in the absence of serum. Phagocytosis was assessed by luminol-enhanced chemiluminescence, inspection of stained smears, bactericidal assay, reduction of nitroblue tetrazolium dye, and electron microscopy. Phagocytosis, determined by visual inspection, occurred at 35 degrees C but not at 4 degrees C. Nonopsonic phagocytosis was inhibited most efficiently by D-mannose, mannose-containing saccharides, and D-fructose. Opsonin-dependent phagocytosis of P. aeruginosa and of zymosan was not markedly inhibited by mannose, suggesting different leukocyte receptors for nonopsonic and opsonic phagocytosis.
Joubertinamine: a novel seco-mesembrane alkaloid (1979)

K. Psotta, F. Strelow and A. Wiechers, J. Chem. Soc., Perkin Trans. 1, 1979, 1063 DOI: 10.1039/P19790001063
Reversible physical absorption of SO2 by ionic liquids (2006)

Ionic liquids can reversibly absorb large amounts of molecular SO(2) gas under ambient conditions with the gas captured in a restricted configuration, possibly allowing SO(2) to probe the internal cavity structures in ionic liquids besides being useful for SO(2) removal in pollution control.
The Stability of Cowpea Mosaic Virus VPg in Reticulocyte Lysates (1986)

Summary The ability of the genome-linked protein (VPg) of cowpea mosaic virus (CPMV) to survive incubation in rabbit reticulocyte lysates was investigated. In contrast to the results obtained with picornavirus RNAs, there was no evidence for the specific removal (‘unlinking’) of the VPg from CPMV RNA during incubation. While linked to RNA, CPMV VPg was protected from proteolytic degradation; if the RNA was first digested with nuclease P1, rapid degradation of the VPg occurred. However if as few as 17 nucleotides were left attached to the VPg, stability was retained.
Reactions of some 4‐methylene‐4<i>H</i>‐pyran derivatives with primary and secondary amines (1970)

Abstract 4‐Dicyanomethylene‐4 H ‐pyrans react with secondary amines to give 2‐aminopyridine and 2‐pyridone derivatives which, in turn, have been used to prepare copyrine derivatives. These pyrans and primary amines gave copyrine and iminopyridone derivatives in addition to the dicyanomethylene‐1,4‐dihydropyridines, which had been reported previously. Reaction of cyanocarbamoylmethylene‐4 H ‐pyrans with secondary amines gave 2‐pyrones, and with primary amines, gave copyrines and 1,4‐dihydropyridine derivatives.
Thin-layer Au-Sn solder bonding process for wafer-level packaging, electrical interconnections and MEMS applications (2009)

The developed bonding process utilizes AuSn solder and provides liquid-proof sealing and multiple reliable electrical connections between the bonded wafers. The bond can withstand 300degC and features a thin bond line (2-3 mum), high bond strength, excellent bond gap control, and low stress due to small amount of bonding material. A Nb/Au seed layer was shown to be an optimal adhesion and barrier film.
Suppression of IEEE 802.11a Interference Based on SVD Algorithm for DS-UWB Communication Systems in Wireless Multipath Channels (2006)

Operating around 5 GHz, IEEE 802.11a systems overlap the band of UWB signals will interfere with UWB systems significantly. In this paper, a novel narrow-band interferences (NBI) suppression technique based on singular value decomposition (SVD) algorithm is presented in direct sequence ultra-wideband (DS-UWB) system. SVD is used to approximate the interferences which then are subtracted from the received signals. By comparing our algorithm with the conventional suppression methods such as notch filter and maximal-ratio combining partial RAKE (MRC PRAKE) receiver, we could conclude that our technique is very effective
A B-ISDN-compatible modem/codec (1991)

Coded modulation techniques for development of a broadband integrated services digital network (B-ISDN)-compatible modem/codec are investigated. The selected baseband processor system must support transmission of 155.52 Mbit/s of data over an INTELSAT 72-MHz transponder. Performance objectives and fundamental system parameters, including channel symbol rate, code rate, and the modulation scheme are determined. From several candidate codes, a concatenated coding system consisting of a coded octal phase shift keying modulation as the inner code and a high rate Reed-Solomon as the outer code is selected and its bit error rate performance is analyzed by computer simulation. The hardware implementation of the decoder for the selected code is also described.
Ultrasonic Double Refraction in Worked Metals (1961)

In the first part of this work the double refraction observed while measuring the attenuation of ultrasonic transverse waves in heat-treated 4150 steel was investigated. Although the data are not complete, they suggest that this double refraction phenomenon can be utilized to detect the amount of preferred orientation of the crystallites in rolled steel when this orientation is small. Calculated values of fractional velocity differences are given. In the second part the theory of ultrasonic wave propagation in polycrystalline metal is discussed, and the effect of preferential orientation of crystallites on fractional velocity changes is indicated. The use of ultrasonic double refraction data for determining the extent of preferential orientation is discussed.