gebhart/patrepeval huggingface dataset:
The Action of Aluminum Chloride on Alkylbenzenes. IV (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Action of Aluminum Chloride on Alkylbenzenes. IVDorothy V. Nightingale and James M. ShackelfordCite this: J. Am. Chem. Soc. 1954, 76, 22, 5767–5770Publication Date (Print):November 1, 1954Publication History Published online1 May 2002Published inissue 1 November 1954https://pubs.acs.org/doi/10.1021/ja01651a041https://doi.org/10.1021/ja01651a041research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of the Antagonistic Effects of Different Angiotensin II Receptor Blockers in Human Coronary Arteries (2002)

Ang II contraction in HCA is mediated mainly by AT(1) but also involves AT(2) receptors. The active metabolite of losartan, EXP 3174, is the most efficacious AT(1) receptor antagonist in HCA.
Sesquiterpene Lactones from Elephantopus scaber (2005)

The ethanolic and acetone extracts of the whole plant of Elephantopus scaber were found to contain ethyl hexadecanoate, ethyl-9,12-octadecadienoate, ethyl-(Z)-9-octadecenoate, ethyl octadecanoate, lupeol, stigmasterol, stigmasterol glucoside, deoxyelephantopin (1) and two new germacranolide sesquiterpene lactones named 17,19-dihydrodeoxyelephantopin (2) and iso-17,19- dihydrodeoxyelephantopin (3) whose stereostructures were determined by spectroscopic methods, comparison with reported data and single-crystal X-ray analysis.
Performance analyses of polarization demultiplexing based on constant-modulus algorithm in digital coherent optical receivers (2011)

In the digital coherent optical receiver, we can achieve polarization demultiplexing in the digital domain, using a two-by-two matrix controlled by the constant-modulus algorithm (CMA). In this paper, after elucidating the physics behind CMA for polarization demultiplexing, we discuss the performance limit of CMA-based polarization demultiplexing through computer simulations. The method of improving its performance is also demonstrated.
Locally Reinforced Polymer-Based Composites for Elastic Electronics (2012)

A promising approach to fabricating elastic electronic systems involves processing thin film circuits directly on the elastic substrate by standard photolithography. Thin film devices are generally placed onto stiffer islands on the substrate surface to protect devices from excessive strain while still achieving a globally highly deformable system. Here we report a new method to achieve island architectures by locally reinforcing polymeric substrates at the macro- and microscale using magnetically responsive anisotropic microparticles. We demonstrate that the resulting particle-reinforced elastic substrates can be made smooth enough for the patterning and successful operation of thin film transistors with transfer characteristics comparable to state-of-the-art devices.
The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function (1997)

Tumor suppressors of the retinoblastoma susceptibility gene family regulate cell growth and differentiation. Polyomavirus large T antigens (large T) bind Rb family members and block their function. Mutations of large T sequences conserved with the DnaJ family affect large T binding to a cellular DnaK, heat shock protein 70. The same mutations abolish large T activation of E2F-containing promoters and Rb binding-dependent large T activation of cell cycle progression. Cotransfection of a cellular DnaJ domain blocks wild-type large T action, showing that the connection between the chaperone system and tumor suppressors is direct. Although they are inactive in assays dependent on Rb family binding, mutants in the J region retain the ability to associate with pRb, p107, and p130. This suggests that binding of Rb family members by large T is not sufficient for their inactivation and that a functional J domain is required as well. This work connects the DnaJ and DnaK molecular chaperones to regulation of tumor suppressors by polyomavirus large T.
Determination of Lithology From Well Logs by Statistical Analysis (1987)

Summary This paper presents a method of predicting lithology by statistical analysis of wireline log measurements with calibration to a core lithology standard. Although an example of the technique applied to the Shublik formation of the Prudhoe Bay area, North Slope, AK, is developed and presented, the method can be applied to any field where some core has been taken. The Shublik, a complex mixture of seven clastic and carbonate rock types, presents a common problem: how can the rock lithology best be identified from wireline logs? During recent work on the reservoir description of the Shublik, it became necessary to answer this question. A lithology standard must be available to calibrate against during development of a log model of lithology. For the Shublik, the core available provided an excellent sample of the total formation. Using the statistical technique of discriminant analysis, we were able to evaluate a number of log models and to choose the most appropriate one. The final log model chosen for the Shublik formation works quite well and correctly predicts lithology 75% of the time.
Secure, Highly Available, and High Performance Peer-to-Peer Storage Systems (2008)

Storage system is an important component in many data intensive applications, including data grid. Security, availability, and high performance are important issues in the storage system design. In this paper we present a peer-to-peer (P2P) storage system design based on distributed hash table (DHT) and short secret sharing (SSS) to provide highly available, secure and efficient data storage services. Existing DHTs do not consider share location and search. Also, storage systems using data partitioning schemes (including SSS) does not consider the severe problems in share update. We develop three access protocols to maintain the share consistency in spite of concurrent update, partial update and compromised storage nodes by storing a limit number of history versions of the shares. We also conducted experimental studies to evaluate the performance and data availability and compare the behaviors of the schemes.
CT-guided needle procedures for brain lesions: 20 years' experience. (2000)

The simple and accurate techniques presented continue to have widespread application in the practice of neurosurgery and compare quite favorably with techniques using more elaborate equipment, stereotactic frames, and intraoperative monitoring.
JAK/STAT Signaling Pathway Regulates Nox1 and Nox4-Based NADPH Oxidase in Human Aortic Smooth Muscle Cells (2009)

JAK/STAT is a key regulator of Nox1 and Nox4 in human vascular SMCs. Inhibition of JAK/STAT pathway and the consequent Nox-dependent oxidative stress may be an efficient therapeutic strategy to reduce atherogenesis.
2 Interventions, Causal Effects, and Causal Relevance (2007)

Abstract This chapter presents and explicates several concepts—namely, those listed in the chapter title—concerning causality and probability that play a fundamental role in the treatment of extrapolation in heterogeneous populations developed in the remainder of the book. Although the concepts of intervention and causal effect are mostly borrowed from other authors, an original definition of positive and negative relevance for examples involving quantitative variables is provided.
Co-Simulation of Self-Adaptive Automotive Embedded Systems (2010)

The complexity of modern vehicular embedded systems is constantly rising. In addition, distributed embedded systems like automobiles often implement safety-relevant applications which have a high demands on safety and reliability. This poses a great challenge for the design of these systems. Self-adaptation may overcome these challenges and enhance the flexibility and robustness of automotive embedded systems. To design such systems in an efficient way, an adaptive system has to be verified and validated even in early stages of the development process. Co-simulation enables such an approach. In this paper, we outline a concept for iterative virtual prototyping of the entire automotive in-vehicle network including hardware components, software functions and interconnection networks. Furthermore, we present an approach to simulate self-adaptive behavior of the automotive embedded system.
Los derechos hereditarios de las mujeres en los bienes de los libertos (2025)

I -INTRODUCCINEst unnimemente admitida entre los romanistas
Effect of dialyser membrane pore size on plasma homocysteine levels in haemodialysis patients (2003)

Super-flux dialysis significantly lowers tHcy in chronic haemodialysis patients. Improved removal of middle-molecule uraemic toxins with inhibitory effects on Hcy-metabolizing enzymes, rather than better dialytic clearance of Hcy itself, may explain the beneficial effect of the super-flux membrane.
Self Adapting Linear Algebra Algorithms and Software (2004)

Abstract — One of the main obstacles to the efficient solution of scientific problems is the problem of tuning software, both to the available architecture and to the user problem at hand. We describe approaches for obtaining tuned high-performance kernels, and for automatically choosing suitable algorithms. Specifically, we describe the generation of dense and sparse blas kernels, and the selection of linear solver algorithms. However, the ideas presented here extend beyond these areas, which can be considered proof of concept. I.
Neural Networks To Predict Ozone Pollution In Industrial Areas (1996)

Publication in the conference proceedings of EUSIPCO, Trieste, Italy, 1996
Synthesis and fungicidal activity of 3,4-dichloroisothiazole based strobilurins as potent fungicide candidates (2017)

A series of 3,4-dichloroisothiazole based novel strobilurin analogs were synthesized, the compound<bold>8d</bold>was discovered as a new fungicidal candidate with better efficacy than commercial standards.
Kinetics of NaCl nucleation in supercritical water investigated by molecular dynamics simulations (2007)

At system pressures between 17 MPa and 25 MPa the nucleation and growth of NaCl nanoparticles in water at supercritical conditions was investigated by molecular dynamics simulations at different system temperatures and system densities. Our results show that particle formation takes place within a few hundred picoseconds after the jump from ambient to supercritical conditions. After nucleation a phase of growth by adding monomers is followed by growth via cluster-cluster collisions. We present results on the time development of distributions of cluster sizes, cluster compositions, and cluster temperatures as well as radial distribution functions and nucleation rates.
Molecular dynamics simulations of unfolding and refolding of a β-hairpin fragment of protein G (1999)

We have studied the unfolding and refolding pathway of a beta-hairpin fragment of protein G by using molecular dynamics. Although this fragment is small, it possesses several of the qualities ascribed to small proteins: cooperatively formed beta-sheet secondary structure and a hydrophobic "core" of packed side chains. At high temperatures, we find that the beta-hairpin unfolds through a series of sudden, discrete conformational changes. These changes occur between states that are identified with the folded state, a pair of partially unfolded kinetic intermediates, and the unfolded state. To study refolding at low temperatures, we perform a series of short simulations starting from the transition states of the discrete transitions determined by the unfolding simulations.
Development of wafer level NCF (non conductive film) (2008)

The wafer level non conductive film (WL-NCF) has been developed, which has dynamic temperature dependence of viscosity. The b-stage WL-NCF was laminated onto the wafer without void, which has 870 Au bumps of 15 mum height and 25 mum pitch. The wafer with the WL-NCF on the surface was cut into chips by standard dicing process. The chip which has the NCF on the surface was bonded onto the ITO wired glass substrate by a flip chip bonder and the electrical connection was confirmed.
Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles (2016)

The hair follicle (HF) is a complex miniorgan that serves as an ideal model system to study stem cell (SC) interactions with the niche during growth and regeneration. Dermal papilla (DP) cells are required for SC activation during the adult hair cycle, but signal exchange between niche and SC precursors/transit-amplifying cell (TAC) progenitors that regulates HF morphogenetic growth is largely unknown. Here we use six transgenic reporters to isolate 14 major skin and HF cell populations. With next-generation RNA sequencing, we characterize their transcriptomes and define unique molecular signatures. SC precursors, TACs, and the DP niche express a plethora of ligands and receptors. Signaling interaction network analysis reveals a bird's-eye view of pathways implicated in epithelial-mesenchymal interactions. Using a systematic tissue-wide approach, this work provides a comprehensive platform, linked to an interactive online database, to identify and further explore the SC/TAC/niche crosstalk regulating HF growth.
Hypoglycemia: A Potent Stimulus to Secretion of Growth Hormone (1963)

In normal subjects, hypoglycemia produces an abrupt and sustained rise in levels of human growth hormone in plasma. This effect is independent of insulin, glucagon, or epinephrine. Prolonged fasting is accompanied by a rise in the hormone level in plasma. Measurement of this hormone after induced hypoglycemia is a specific test for pituitary somatotropic function.
The analysis of the continuous-time LMS algorithm (1989)

A continuous-time analog adaptive filter is suggested using the digital prototype. The continuous-time LMS (least-mean squares) algorithm is then described by a set of simultaneous first-order equations. The adaptive gain is shown to be unbounded theoretically.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Paget's Disease of Bone and Genetic Disorders of RANKL/OPG/RANK/NF‐κB Signaling (2006)

Identification of the RANKL/OPG/RANK/NF-kB (receptor activator of nuclear factor kappa-B ligand / osteoprotegerin) signaling pathway as the major regulatory system for osteoclastogenesis began with discovery of these ligands and receptors in the tumor necrosis factor (TNF) superfamily. Subsequently, genetically altered mice revealed physiologic roles for these proteins in bone biology. However, full appreciation of their significance for the human skeleton came from clinical characterization of several extremely rare, heritable disorders followed by discovery of their genetic bases. Familial expansile osteolysis (FEO) is an autosomal dominant disorder featuring constitutive activation of RANK due to an 18-bp tandem duplication in its gene (TNFRSF11A). A similar, 27-bp duplication causes what has been called a familial form of early-onset Paget's disease of bone (PDB2). Expansile skeletal hyperphosphatasia (ESH) is allelic to FEO and PDB2 and involves a 15-bp tandem duplication in TNFRSF11A. Autosomal recessive inheritance of deactivating mutations of the gene encoding OPG (TNFRSF11B) causes most cases of juvenile Paget disease. These disorders feature high bone turnover, deafness during early childhood, "idiopathic external lysis" of adult teeth, and sometimes focal lesions in appendicular bones that mimic active PDB. Biochemical markers indicate rapid skeletal remodeling. In FEO, osteolysis progresses to fat-filled bone rather than to osteosclerosis. Antiresorptive therapy with bisphosphonates can be effective for each disorder.
Low-cost laser speckle contrast imaging of blood flow using a webcam (2013)

Laser speckle contrast imaging has become a widely used tool for dynamic imaging of blood flow, both in animal models and in the clinic. Typically, laser speckle contrast imaging is performed using scientific-grade instrumentation. However, due to recent advances in camera technology, these expensive components may not be necessary to produce accurate images. In this paper, we demonstrate that a consumer-grade webcam can be used to visualize changes in flow, both in a microfluidic flow phantom and in vivo in a mouse model. A two-camera setup was used to simultaneously image with a high performance monochrome CCD camera and the webcam for direct comparison. The webcam was also tested with inexpensive aspheric lenses and a laser pointer for a complete low-cost, compact setup ($90, 5.6 cm length, 25 g). The CCD and webcam showed excellent agreement with the two-camera setup, and the inexpensive setup was used to image dynamic blood flow changes before and after a targeted cerebral occlusion.
Analysis of predictive spatio-temporal queries (2003)

Given a set of objects S , a spatio-temporal window query q retrieves the objects of S that will intersect the window during the (future) interval q T . A nearest neighbor query q retrieves the objects of S closest to q during q T . Given a threshold d , a spatio-temporal join retrieves the pairs of objects from two datasets that will come within distance d from each other during q T . In this article, we present probabilistic cost models that estimate the selectivity of spatio-temporal window queries and joins, and the expected distance between a query and its nearest neighbor(s). Our models capture any query/object mobility combination (moving queries, moving objects or both) and any data type (points and rectangles) in arbitrary dimensionality. In addition, we develop specialized spatio-temporal histograms, which take into account both location and velocity information, and can be incrementally maintained. Extensive performance evaluation verifies that the proposed techniques produce highly accurate estimation on both uniform and non-uniform data.
The effects of acetylcholine on response properties of cat somatosensory cortical neurons (1988)

1. Two-hundred thirty-three single neurons were isolated and studied in somatosensory cortex of cats anesthetized with pentobarbital sodium or urethane. Two-hundred and three were studied during iontophoretic administration of acetylcholine (ACh), 173 during administration of glutamate, and 24 during administration of atropine. 2. Fifty-six percent of the 218 neurons tested responded to somatic stimuli. Another 21% did so during glutamate administration. In 11 cases ACh iontophoresis uncovered a receptive field in a previously unresponsive cell. 3. Forty-six percent of the 160 cells tested responded to thalamic stimulation. Another 17% did so in the presence of glutamate, but 19 cells responded to neither cutaneous nor thalamic stimuli. 4. Sixteen percent of the 203 cells tested were overtly excited by ACh and the responses to somatic stimulation of 29% were modulated by administration of ACh. Cells displaying overt excitation and/or modulation of responses were said to be cholinoceptive and made up 39% of the sample. These cells were located in all cortical layers. 5. Cholinoceptive neurons were more likely than noncholinoceptive cells to be driven by thalamic stimulation. 6. The changes observed during ACh administration tended to be facilitatory: an enhanced responsiveness to somatic stimuli, an increased firing rate, or an increased receptive-field size. However, in 10 of the 203 cases tested one or more of these variables decreased. 7. The enhanced responsiveness during ACh administration was a robust phenomenon; responses were often increased by as much as 200% and the discharge pattern was altered so that bursts of impulses following stimulation were more common. 8. ACh tended to enhance one attribute of a cell selectively rather than to act as a general excitant. 9. ACh is a powerful neuromodulatory agent in somatosensory cortex that, when released in specific behavioral states, should enhance the responsiveness of cortical neurons.
An atypical phenotype of macular and peripapillary retinal atrophy caused by a mutation in the RP2 gene (2004)

The distinct phenotype in this family, caused by this frameshifting mutation in RP2, broadens the phenotypic spectrum of X linked retinitis pigmentosa. The absence of RP2 protein suggests that loss of protein function and not novel gain of function could account for the atypical phenotype. A definitive diagnosis of X linked retinitis pigmentosa permits appropriate genetic counselling with important implications for other family members. Clinicians should have a low threshold for screening RP2 in families with retinal dystrophy, including posterior retinal disease, not immediately suggestive of X linked inheritance.
Micro- and Nanopatterned Star Poly(ethylene glycol) (PEG) Materials Prepared by UV-Based Imprint Lithography (2007)

A UV-based imprint lithography method is used for the direct surface structuring of hydrogel-based biomaterials, which are prepared from a family of tailor-made star poly(ethylene glycol) formulations. Bulk star poly(ethylene glycol) (PEG) hydrogels are fabricated by cross-linking acrylate-functionalized star PEG macromolecules. Cross-linking is achieved by radical reactions initiated by UV irradiation. This UV-curable star PEG formulation allows templating of mold structures to yield a stable, stand-alone, elastomeric replica of the mold. In particular, when a secondary, soft mold is used that consists of a perfluorinated elastomer with inherent excellent release properties, nanometer-sized features (down to 100 nm) can be imprinted without specialized equipment. The applied UV-based imprint lithography is a fast and simple technique to employ for the direct topographic structuring of bulk PEG-based biomaterials. The UV-based imprinting into the star PEG prepolymer by means of a perfluorinated, soft mold can be carried out on the bench top, while nanoscale resolution is demonstrated.