gebhart/patrepeval huggingface dataset:
Studies in anthracycline synthesis: simple Diels-Alder routes to pachybasin, .omega.-hydroxypachybasin, aloe-emodin, and fallacinol (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies in anthracycline synthesis: simple Diels-Alder routes to pachybasin, .omega.-hydroxypachybasin, aloe-emodin, and fallacinolNicholas Benfaremo and Michael P. CavaCite this: J. Org. Chem. 1985, 50, 1, 139–141Publication Date (Print):January 1, 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/jo00201a033https://doi.org/10.1021/jo00201a033research-articleACS PublicationsRequest reuse permissionsArticle Views566Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Face Parsing with RoI Tanh-Warping (2019)

Face parsing computes pixel-wise label maps for different semantic components (e.g., hair, mouth, eyes) from face images. Existing face parsing literature have illustrated significant advantages by focusing on individual regions of interest (RoIs) for faces and facial components. However, the traditional crop-and-resize focusing mechanism ignores all contextual area outside the RoIs, and thus is not suitable when the component area is unpredictable, e.g. hair. Inspired by the physiological vision system of human, we propose a novel RoI Tanh-warping operator that combines the central vision and the peripheral vision together. It addresses the dilemma between a limited sized RoI for focusing and an unpredictable area of surrounding context for peripheral information. To this end, we propose a novel hybrid convolutional neural network for face parsing. It uses hierarchical local based method for inner facial components and global methods for outer facial components. The whole framework is simple and principled, and can be trained end-to-end. To facilitate future research of face parsing, we also manually relabel the training data of the HELEN dataset and will make it public. Experiments on both HELEN and LFW-PL benchmarks demonstrate that our method surpasses state-of-the-art methods.
[Rheology of bronchial secretions and mucociliary transport (author's transl)]. (1977)

Optimal relationships between mucociliary clearance and rheological properties of bronchial secretions expectorated by patients with chronic bronchitis have been analysed by successive measurements of visco-elasticity with a rotational rheometer and of transport velocity on frog palate mucosa. It appears that the role of the elastic component is predominent. Sputum characterized by very low strain recovery (SR less than 4 units) or conversely by very high elasticity (SR greater than 20 units) is transported at a low rate in comparison to that of the control frog mucus (relative transport rate less than 0.5). Pronounced hyperviscosity of sputum (no greater than 200 poises) appears also as a limiting factor to the mucociliary transport. The best transported secretions (relative transport rate greater than 0.7) are characterized by a relative elasticity (SR) of 4 to 13 units and a viscosity (no) of 25 to 200 poises. Under the action of mucolytic agents such as N-acetylcysteine, sputum initially characterized by low strain recovery (SR less than 4 units) is transported at a much slower rate which is related to the increased loss of elasticity. These results indicate that mucolytic drugs must be administered with great care in patients with chronic bronchitis. Moreover, they should not be used in patients with very low visco-elastic secretions which reflect the non-functional state of the bronchial mucosa.
Techniques for area estimation of VLSI layouts (1989)

The standard cell design style is investigated. Two probabilistic models are presented. The first model estimates the wiring space requirements in the routing channels between the cell rows. The second model estimates the number of feedthroughs that must be inserted in the cell rows to interconnect cells placed several rows apart. These models were implemented in the standard cell area estimation program PLEST (PLotting ESTimator). PLEST was used to estimate the areas of a set of 12 standard cell chips. In all cases, the estimates were accurate to within 10% of the actual areas. PLEST's estimation of a chip layout area takes only a few seconds to produce, as compared with more than 10 h to generate the chip layout itself using an industrial layout system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Design of time delayed control systems in UAV using model based predictive algorithm (2010)

There is large time delay in `man-in-the loop' unmanned aircraft vehicle (UAV) system, especially for remote control flight by satellite communication. Time delay has great impacts on UAV and payload control, which can lead to the system unstable. Considering the character that the UAV was operated through man-machine interface, reference model based state predictive algorithm was proposed to solve the transport delay problem. The estimated state variant was displayed in the visual interface to compensate time delay. An aircraft's pitch angle control loop was designed employing this method. The simulation results indicate the compensation algorithm is effective to decrease the effect of time delay.
Enforcing 3D Constraints To Improve Object and Scene Recognition (2007)

This paper presents an extension to David Lowe's well-known object recognition algorithm based on his Scale and Feature Invariant Transform (SIFT).One of the benefits of Lowe's SIFT-based method is that it can recognize objects from only three keypoints.While this capability can be useful in circumstances where the cost of a false negative is high, it's often the case that false positive are an equal, or greater, concern.We extend Lowe's algorithm by adding the ability to use 3D constraints during matching.These constraints essentially eliminate false positive matches.We combine our extension with the original algorithm to retain the recognition power of the original method while adding significant robustness against false positives, thereby increasing overall classification power.In addition to improving recognition, our extension returns 3D pose information.Yet, it adds very little computational overhead to Lowe's original algorithm.
Acidic domains around nucleic acids. (1990)

The hydrogen ion concentration in the vicinity of DNA was mapped out within the Poisson-Boltzmann approximation. Experimental conditions were modeled by assuming Na-DNA to be solvated in a buffer solution containing 45 mM Tris and 3 mM Mg cations at pH 7.5. Three regions of high H+ concentration (greater than 10 microM) are predicted: one throughout the minor groove of DNA and two localized in the major groove near N7 of guanine and C5 of cytosine for a G.C base pair. These acidic domains correlate well with the observed covalent binding sites of benzo[a]pyrene epoxide (N2 of guanine) and of aflatoxin B1 epoxide (N7 of guanine), chemical carcinogens that presumably undergo acid catalysis to form highly reactive carbocations that ultimately bind to DNA. It is suggested that these regions of high H+ concentration may also be of concern in understanding interactions involving proteins and noncarcinogenic molecules with or near nucleic acids.
Influence of the Renal Endothelin System on the Autoregulation of Renal Blood Flow in Spontaneously Hypertensive Rats (1997)

The renal endothelin (ET) system has been claimed to play an important role in the regulation of renal blood flow (RBF) and sodium excretion in primary hypertension. The aim of the present study was to investigate the contribution of the endogenous ET system in the autoregulation of total RBF, cortical blood flow (CBF), pressure-dependent plasma renin activity (PRA) and pressure natriuresis in spontaneously hypertensive rats (SHR) by means of the combined (A/B) ET-receptor antagonist, bosentan. In anesthetized rats, RBF was measured by transit-time flow probes and CBF by laser flow probes. During the experiments, the rats received an intrarenal infusion of either bosentan (1 mg/kg/h) or vehicle. Renal perfusion pressure (RPP) was lowered in pressure steps of 5 mm Hg with a servo-controlled electropneumatic device via an inflatable suprarenal cuff. Bosentan had no effect on resting RPP, CBF, PRA and renal sodium excretion, whereas RBF was lowered by 30% (p < 0.05). Furthermore after bosentan the rats revealed a complete loss of RBF autoregulation. In contrast no changes in autoregulation of CBF, pressure-dependent PRA and pressure natriuresis were observed. Our findings demonstrate a significant impairment in total RBF autoregulatory ability during renal ET-receptor blockade which is not confined to the cortical vessels. These data suggest that the renal ET system plays an important role in the dynamic regulation of renal blood flow in SHR.
Dual Quarter-Wavelength Hairpin Bandpass Filter with Multiple Transmission Zeros (2006)

A novel dual quarter-wavelength (lambda/4) hairpin microstrip resonator is proposed, which is composed of two lambda/4 stepped-impedance resonators (SIR's) that are coupled through a shorted stub section. In this study, the dual resonator structure is utilized to design a bandpass filter for which the filter order may be doubled and the via number required in the conventional lambda/4 filter may be reduced to half. Specifically, a four-pole quasi-elliptic microstrip filter is realized with two pairs of transmission zeros created around the passband edges so that the filter selectivity may be improved
Laser-Based Finger Tracking System Suitable for MOEMS Integration (2003)

This paper describes a proof-of-principle demonstration of a novel and simple active tracking mechanism using a laser diode, steering mirrors, and a single non-imaging photodetector. Tracking is based on the analysis of a temporal signal corresponding to the amount of backscattered light produced during a rapid, local circular scan (or saccade) around the presumed object position. The simplicity of the system is such that, using state-of-the-art Micro-Opto-Electro-Mechanical-System (MOEMS) technology, it would be possible to integrate the whole system on a chip, making it an interesting input interface for portable computing devices.
Neutrophil CD18-dependent arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow can be activated through L-selectin (1997)

Neutrophil emigration through endothelial cells under shear flow involves several adhesion processes including cell rolling, arrest, and transmigration. Rolling is mediated by selectins, while arrest and transmigration both require activated CD18 integrins. One mode of CD18 activation is via selectins expressed on neutrophils and endothelial cells. We have recently reported that cross-linking of L-selectin (CD62L) resulted in the rapid activation of CD18-dependent adhesion. In the current study, we examine whether binding of E-selectin (CD62E) and L-selectin can activate neutrophil CD18-dependent adhesion under shear flow. Human ICAM-1 (CD54) and E-selectin were co-transfected into L cells. Neutrophil capture, rolling, and arrest on these monolayers were quantitated in a parallel plate flow chamber at a wall shear stress of 2.0 dyne/cm2. Under these conditions, E-selectin supported cell capture and rolling on the monolayer, but did not trigger CD18-mediated cell arrest within 200 microm of rolling. However, when neutrophils were treated with anti-L-selectin mAb and cross-linked with a secondary mAb, approximately 50% of the cells arrested within 54 microm. Cell arrest was also observed in response to IL-8 stimulation. A subthreshold level of IL-8 in combination with L-selectin cross-linking potentiated the level of cell arrest due to either stimulus alone. The transition to cell arrest involved both LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). Blocking either subunit alone failed to reduce arrest, while blocking both molecules with mAbs reduced the number to baseline levels. These data support the conclusion that L-selectin, but not E-selectin, can signal the transition from neutrophil rolling to cell arrest under shear flow.
Computer Vision Technologies for Remote Collaboration Using Physical Whiteboards, Projectors and Cameras (2006)

A whiteboard provides a large shared space for the participants to focus their attention and express their ideas, and is therefore a great collaboration tool for information workers. However, it has several limitations; notably, the contents on the whiteboard are hard to archive or share with people who are not present in the discussions. This paper presents our work in developing tools to facilitate collaboration on physical whiteboards by using a camera and a microphone. In particular, we have developed two systems: a whiteboard-camera system and a projector-whiteboardcamera system. The whiteboard-camera system allows a user to take notes of a whiteboard meeting when he/she wants or in an automatic way, to transmit the whiteboard content to remote participants in real time and in an efficient way, and to archive the whole whiteboard session for efficient post-viewing. The projector-whitebord-camera system incorporates a whiteboard into a projectorcamera system. The whiteboard serves as the writing surface (input) as well as the projecting surface (output). Many applications of such a system inevitably require extracting handwritings from video images that contain both handwritings and the projected content. By analogy with echo cancellation in audio conferencing, we call this problem visual echo cancellation, and we describe one approach to accomplish the task. Our systems can be retrofit to any existing whiteboard. With the help of a camera and a microphone and optionally a projector, we are effectively bridging the physical and digital worlds.
A Database for Selection of Rehabilitation Techniques of Sewer Pipes (2000)

Automation in construction gained sizable momentum during the last decade and considerable efforts have been made to benefit from this emerging technology in reducing cost and improving quality of work performed in this industry. This is particularly true in inspection and maintenance tasks of infrastructure facilities. This paper presents an automated system for inspection of sewer pipes. The system can detect, classify and recommend the most suitable rehabilitation techniques for a number of defects that commonly exist in this class of pipes. The system consists of two main sub-systems: detection and rehabilitation. The paper briefly describes the developed automated detection sub-system and focuses primarily on the conceptual design of the rehabilitation sub-system.
The Correlation between Increased Serum Concentrations of Interleukin-6 Family Cytokines and Disease Activity in Rheumatoid Arthritis Patients (2010)

The serum concentrations of IL-6 family cytokines were significantly elevated in patients with RA, and they decreased with medical treatment. These findings suggest a possible role for IL-6 family cytokines in the pathogenesis of RA.
Early effects of pharmacological androgen deprivation in human prostate cancer (2006)

Pharmacological AD induces significant involution within prostatic tissues over 7-28 days, but allows the persistence of some viable tumour cells capable of proliferation.
File-Level, Host-Side Flash Caching with Loris (2013)

As enterprises shift from using direct-attached storage to network-based storage for housing primary data, flash-based, host-side caching has gained momentum as the primary latency reduction technique. In this paper, we make the case for integration of flash caching algorithms at the file level, as opposed to the conventional block-level integration. In doing so, we will show how our extensions to Loris, a reliable, file-oriented storage stack, transform it into a framework for designing layout-independent, file-level caching systems. Using our Loris prototype, we demonstrate the effectiveness of Loris-based, file-level flash caching systems over their block-level counterparts, and investigate the effect of various write and allocation policies on the overall performance.
Effect of Erythropoietin Axotomy-Induced Apoptosis in Rat Retinal Ganglion Cells (2004)

These data support a potential role for EPO as a therapeutic molecule against predominantly apoptotic neuronal cell death in the context of glaucoma or neurodegenerative diseases and delineate the PI-3-K/Akt pathway as the predominant mediator of EPO neuroprotection in this in vivo paradigm of neuronal cell death.
Embedded UML (2001)

In this paper, we present a proposal for a UML profile called `Embedded UML'. Embedded UML represents a synthesis of various ideas in the real-time UML community, and concepts drawn from the Hardware-Software co-design field. Embedded UML first selects from among the competing real-time UML proposals, the set of ideas which best allow specification and analysis of mixed HW-SW systems. It then adds the necessary concept of underlying deployment architecture that UML currently lacks in complete form, using the notion of an embedded HW-SW `platform'. It supplements this with the concept of a `mapping', which is a platform-dependent refinement mechanism that allows efficient generation of an optimised implementation of the executable specification in both HW and SW. Finally, it provides an approach which supports the development of automated analysis, simulation, synthesis and code generation tool capabilities which can be provided for design usage even while the embedded UML standardisation process takes place.
The outcomes of patients with very small coronary artery disease treated with thin strut cobalt chromium bare metal stents: an observational study (2016)

This study has demonstrated that the use of thin strut cobalt chromium BMS in very small vessel CAD was reasonably safe and efficacious in the context of 'real-world' practice.
Purification et proprietes de l'alpha-galactosidase des graines germees de Vicia sativa (1969)

α-Galactosidase from germinating Vicia sativa seeds has been extracted with a 0.9% NaCl solution. Treatment with manganous sulphate eliminated inactive fractions. The enzyme was precipitated from the supernatant with (NH4)2SO4 at 80% saturation, redissolved in water and dialyzed. Purification was further increased by three successive steps of column chromatography. Only fractions showing α-galactosidase activity have been used for each subsequent step. Successive passage through two hydroxylapatite and one Sephadex column gave an enzyme with a specific activity 1,100 times higher than that of the crude extract, and with a yield of 10% from the original material. The enzyme thus obtained behaves as a single protein in electrophoresis on Cellogel. Sedimentation in a sucrose gradient and ultracentrifugation in an analytical ultracentrifuge suggest a molecular weight of about 30,000. The protein is rich in aspartic and glutamic acids and has a low cysteine content. Dansylation and the dinitrofluorobenzene method showed the presence of a single N-terminal residue which was identified as l-alanine. The purified α-galactosidase seems therefore to be a single polypeptide chain. The pH optimum of the α-galactosidase is 6.3. The enzyme is not very sensitive to thermal inactivation and is devoid of activity on α-glucosides and β-galactosides. It hydrolyses phenyl-α-galactoside rapidly and galactinol very slowly. Unlike the α-galactosidase from coffee beans it does not liberate galactose from the galactomannans of Leguminoseae. Michaelis constants at pH6.3 are markedly different for the different substrates: Km= 9.7 × 10−4 for p-nitrophenyl-α-galactoside; 3.8 × 10−3 for phenyl-α-galactoside; 5.8 × 10−2 for raffinose and 4.1 × 10−1 for galactinol. In the case of the two phenol galactosides a strong inhibition was observed with excess substrate. This inhibition does not take place with raffinose or galactinol as substrate. α-Galactosidase is inhibited by Hg2+, Ag+ and weakly activated by Fe3+, Zn2+ and Mn2+. A transferase activity was observed with phenyl-α-galactoside as donor and various acceptors: glucose, mannose, galactose, cellobiose and sucrose. Raffinose also acts as an α-galactosyl donor. With galactinol as acceptor the following compound is formed: Galpα1-6Galpα-1′-myoinositol.
The effects of QuikClot Combat Gauze on hemorrhage control in the presence of hemodilution. (2012)

QCG produces a robust clot that can more effectively tolerate hemodilution compared to a control group.
A transport protocol for supporting multimedia streaming in mobile ad hoc networks (2003)

Transport protocol design for supporting multimedia streaming in mobile ad hoc networks is challenging because of unique issues, including mobility-induced disconnection, reconnection, and high out-of-order delivery ratios; channel errors and network congestion. In this paper, we describe the design and implementation of a transmission control protocol (TCP)-friendly transport protocol for ad hoc networks. Our key design novelty is to perform multimetric joint identification for packet and connection behaviors based on end-to-end measurements. Our NS-2 simulations show significant performance improvement over wired TCP friendly congestion control and TCP with explicit-link-failure-notification support in ad hoc networks.