gebhart/patrepeval huggingface dataset:
Association in segregating populations of chickpea. (1980)

Correlation and path coefficients were studied in F2 and F3 generations of three diverse crosses of chickpea. Seed yield was positively and significantly correlated with pods per plant and seed number per plant followed by secondary and primary branches. Association of yield with seeds per pod and 100-seed weight were positive but non-significant in most of the populations studied. However, even with non-directed selection more favourable and effective character association developed in F3 progenies than among their F2 parents. Pathcoefficient analysis revealed that pods per plant and seeds per plant registered maximum positive direct effect with yield. The indirect effects of other attributes were also maximum through these two characters. In the light of present findings component selection with greater emphasis on branches per plant, pods per plant and seeds per plant has been suggested in chickpea.
Molecular Epidemiology of<i>Mycobacterium abscessus</i>, with Focus on Cystic Fibrosis (2007)

Mycobacterium abscessus has been isolated increasingly often from the respiratory tracts of cystic fibrosis (CF) patients. It is not known whether these organisms are transmitted from person to person or acquired from environmental sources. Here, colony morphology and pulsed-field gel electrophoresis (PFGE) pattern were examined for 71 isolates of M. abscessus derived from 14 CF patients, three non-CF patients with chronic respiratory M. abscessus infection or colonization, one patient with mastoiditis, and four patients with infected wounds, as well as for six isolates identified as environmental contaminants in various clinical specimens. Contaminants and wound isolates mainly exhibited smooth colony morphology, while a rough colony phenotype was significantly associated with chronic airway colonization (P=0.014). Rough strains may exhibit increased airway-colonizing capacity, the cause of which remains to be determined. Examination by PFGE of consecutive isolates from the same patient showed that they all represented a single strain, even in cases where both smooth and rough isolates were present. When PFGE patterns were compared, it was shown that 24 patients had unique strains, while four patients harbored strains indistinguishable by PFGE. Two of these were siblings with CF. The other two patients, one of whom had CF, had not had contact with each other or with the siblings. Our results show that most patients colonized by M. abscessus in the airways have unique strains, indicating that these strains derive from the environment and that patient-to-patient transmission rarely occurs.
Conformation-activity relationships of opioid peptides with selective activities at opioid receptors (1999)

The discovery of endogenous opioid peptides 25 years ago opened up a new chapter in efforts to understand the origins and control of pain, its relationships to other biological functions, including inflammatory and other immune responses, and the relationships of opioid peptides and their receptors to a variety of undesirable or toxic side effects often associated with the nonpeptide opiates such as morphine including addiction, constipation, a variety of neural toxicities, tolerance, and respiratory depression. For these investigations the need for potent and highly receptor selective agonists and antagonists has been crucial since they in principle allow one to distinguish unequivocally the roles of the different opioid receptors (mu, delta, and kappa) in the various biological and pathological roles of the opioid peptides and their receptors. Conformational and topographical constraint of the linear natural endogenous opioid peptides has played a major role in developing peptide ligands with high selectivity for mu, delta, and kappa receptors, and in understanding the conformational, topographical, and stereoelectronic structural requirements of the opioid peptides for their interactions with opioid receptors. In turn, this had led to insights into the three-dimensional pharmacophore for opioid receptors. In this article we review and discuss some of the developments that have led to potent, selective, and stable peptide and peptidomimetic ligands that are highly potent and selective, and that have delta agonist, mu antagonist, and kappa agonist biological activities (other authors in this issue will discuss the development of other types of activities and selectivities). These have led to ligands that provide unique insight into opioid pharmacophores and the critical roles opioid ligands and receptor scan play in pain, addiction, and other human maladies.
Polymers Go with the Flow (2003)

The flow of polymer melts and solutions differs substantially from that of other liquids, because the long polymer chains can become entangled and cannot cross each other freely in their motion. In his Perspective, Marrucci provides an overview of theoretical attempts to explain polymer flow. He highlights the report by Bent et al., who have performed sophisticated experiments on linear polymers that prove key elements of the latest theory. Furthermore, the approach used by the authors will become an important experimental tool for investigating more complex polymer systems.
Photothermal Single-Particle Microscopy: Detection of a Nanolens (2012)

Combining quantitative photothermal microscopy and light scattering microscopy as well as accurate MIE scattering calculations on single gold nanoparticles, we reveal that the mechanism of photothermal single-molecule/particle detection is quantitatively explained by a nanolensing effect. The lensing action is the result of the long-range character of the refractive index profile. It splits the focal detection volume into two regions. Our results lay the foundation for future developments and quantitative applications of single-molecule absorption microscopy.
Electrical series connection drive for several hybrid‐transducer ultrasonic motors (1998)

It is difficult to manufacture motors that combine superior characteristics and optimum driving conditions with a high mechanical Q value in torsional and longitudinal oscillation systems composed of hybrid-transducer ultrasonic motors. In a system that uses several motors at once, the drive and control systems become complicated, thereby creating problems. In this paper, the authors show that several motors may be treated as one vibration system by connecting the electrical terminals of each vibration system in series, even when the vibration system has differing mechanical impedances, and conversion coefficients for current-vibration velocity such as the torque factor and the force factor. The authors then show that a driving system for several motors using this method can be accomplished simply. In experiments using Langevin torsional transducers, the vibration velocity of two vibration systems with differing resonant frequencies and free motional admittance reaches a maximum at the same driving frequency in electrical series connections, and confirm that phase synchronization is complete. Furthermore, the authors confirm experimentally the effectiveness of series connections with respect to two applications of a velocity synchronization drive in which the torque accumulation combines several motors with hollow structures along the drive axis, and the rotational velocities of several independent motors match. © 1998 Scripta Technica, Electron Comm Jpn Pt 3, 81(12): 11–12, 1998
Uber die Umsetzung von Disulfurylfluorid, S<sub>2</sub>O<sub>5</sub>F<sub>2</sub>, mit Ammoniak und Diäthylamin (1961)

Abstract Die Einwirkung von Ammoniak oder Aminen auf Disulfurylfluorid im Mol‐Verhältnis 2:1 führt bei niederen Temperaturen nicht zu einer Fluor‐Substitution. Der primäre Reaktionsschritt ist die ammonolytische Spaltung der SOS‐Bindung. Die Umsetzung ist zur präparativen Gewinnung des Amidoschwefelsäurefluorids und seiner N‐Alkylderivate geeignet.
Specific Imaging of Bacterial Infection Using 6″-<sup>18</sup>F-Fluoromaltotriose: A Second-Generation PET Tracer Targeting the Maltodextrin Transporter in Bacteria (2017)

6″-<sup>18</sup>F-fluoromaltotriose is a PET tracer that can potentially be used to image and localize most bacterial infections, much like <sup>18</sup>F-FDG has been used to image and localize most cancers. However, unlike <sup>18</sup>F-FDG, 6″-<sup>18</sup>F-fluoromaltotriose is not taken up by inflammatory lesions and appears to be specific to bacterial infections by targeting the maltodextrin transporter that is expressed in gram-positive and gram-negative strains of bacteria. <b>Methods:</b> 6″-<sup>18</sup>F-fluoromaltotriose was synthesized with high radiochemical purity and evaluated in several clinically relevant bacterial strains in cultures and in living mice. <b>Results:</b> 6″-<sup>18</sup>F-fluoromaltotriose was taken up in both gram-positive and gram-negative bacterial strains. 6″-<sup>18</sup>F-fluoromaltotriose was also able to detect <i>Pseudomonas aeruginosa</i> in a clinically relevant mouse model of wound infection. The utility of 6″-<sup>18</sup>F-fluoromaltotriose to help monitor antibiotic therapies was also evaluated in rats. <b>Conclusion:</b> 6″-<sup>18</sup>F-fluoromaltotriose is a promising new tracer that has significant diagnostic utility, with the potential to change the clinical management of patients with infectious diseases of bacterial origin.
Assembly of Alphavirus Replication Complexes from RNA and Protein Components in a Novel <i>trans</i> -Replication System in Mammalian Cells (2011)

For positive-strand RNA viruses, the viral genomic RNA also acts as an mRNA directing the translation of the replicase proteins of the virus. Replication takes place in association with cytoplasmic membranes, which are heavily modified to create specific replication compartments. Here we have expressed by plasmid DNA transfection the large replicase polyprotein of Semliki Forest virus (SFV) in mammalian cells from a nonreplicating mRNA and provided a separate RNA containing the replication signals. The replicase proteins were able to efficiently and specifically replicate the template in trans, leading to accumulation of RNA and marker gene products expressed from the template RNA. The replicase proteins and double-stranded RNA replication intermediates localized to structures similar to those seen in SFV-infected cells. Using correlative light electron microscopy (CLEM) with fluorescent marker proteins to relocate those transfected cells, in which active replication was ongoing, abundant membrane modifications, representing the replication complex spherules, were observed both at the plasma membrane and in intracellular endolysosomes. Thus, replication complexes are faithfully assembled and localized in the trans-replication system. We demonstrated, using CLEM, that the replication proteins alone or a polymerase-negative polyprotein mutant together with the template did not give rise to spherule formation. Thus, the trans-replication system is suitable for cell biological dissection and examination in a mammalian cell environment, and similar systems may be possible for other positive-strand RNA viruses.
Nucleotide sequence of a cDNA coding for the amino-terminal region of human prepro α1(III) collagen (1988)

Journal Article Nucleotide sequence of a cDNA coding for the amino-terminal region of human prepro α1(III) collagen Get access P.D. Toman, P.D. Toman + Present address: Department of Molecular Genetics, M.D. Anderson Hospital and Tumor Institute, Houston, TX 77030 Search for other works by this author on: Oxford Academic PubMed Google Scholar G.A. Ricca, G.A. Ricca Search for other works by this author on: Oxford Academic PubMed Google Scholar B. de Crombrugghe B. de Crombrugghe 1Laboratory of Molecular Biology, National Cancer Institute, National Institutes of HealthBethesda, MD 20205, USA + Present address: Department of Molecular Genetics, M.D. Anderson Hospital and Tumor Institute, Houston, TX 77030 Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 14, 25 July 1988, Page 7201, https://doi.org/10.1093/nar/16.14.7201 Published: 25 July 1988 Article history Received: 12 April 1988 Published: 25 July 1988
Buried Power Rails and Back-side Power Grids: Arm<sup>®</sup> CPU Power Delivery Network Design Beyond 5nm (2019)

The technology of buried power rails and back-side power delivery has been proposed for future scaling enablement, beyond the 5nm technology node. This paper studies the CPU design implications of power delivery in the context of these technologies. Employing standard VLSI design flows and sign-off techniques, we benchmark the power delivery designs and technology options using the Arm Cortex-A53 CPU at an imec 3nm technology node. DC and AC analyses of the resulting power delivery networks are presented for the various designs with buried power rails (with front-side and back-side power delivery) and compared to conventional designs without buried power rails. It is shown that buried rails with front-side power delivery can improve the worst-case IR drop from 70mV to 42mV (~1.7X reduction) while buried rails with back-side power delivery substantially reduce IR drop to 10mV (a 7X reduction).
Molecular Sieve Zeolites-I (1974)

Zeolite properties are being studied by nearly every type of modern scientific discipline, and they are being utilized in many new chemical engineering processes. Important advances include detailed basic information on cations in zeolites, more understanding of the mechanism of zeolite formation, the formation and character of structural defects and hydroxyl groups, the role of zeolite structure in adsorption and catalysis, and the increasing technology of the use of molecular sieve zeolites in catalysis and adsorption.
Isoquinoline Alkaloids from <i>Macleaya cordata</i> Active against Plant Microbial Pathogens (2009)

Bioassay-guided fractionation of the crude extract of the whole plant of Macleaya cordata R. Br. led to the isolation of four alkaloids, which were identified as sanguinarine (1), chelerythrine (2), protopine (3) and alpha-allocryptopine (4) on the basis of their physicochemical and spectrometric data. Compounds 1 and 2 demonstrated a significant antifungal activity against the six test fungi with median inhibitory concentrations (IC50) ranging from 0.47 to 6.13 microg/mL. Compound 1 was the most effective with an IC50 of 0.47 microg/mL on Rhizoctonia solani. Furthermore, compounds 1 and 2 also demonstrated strong antibacterial activity, with IC50 values ranging from 5.01 to 11.3 microg/mL, and minimum inhibitory concentrations (MIC) ranging from 8.0 to 32.0 microg/mL. This is the first report on the activity of the alkaloids from M. cordata against economically important phytopathogenic fungi and bacteria.
The use of gradient flow compensation to separate diffusion and microcirculatory flow in MRI (1991)

This paper describes a new MR imaging technique termed Modified Stejskal Tanner versus Flow Compensation (MST/FC) for the separation of diffusion and microcirculatory flow. The theory behind the sequence is explained, along with a five-component model of microcirculation applicable to any "perfusion" imaging technique. Phantom data is presented showing that (1) diffusion effects can be matched between MST and FC (suggesting the possibility of flow-compensated diffusion imaging), and (2) the technique is a quantitative method of separating diffusion and slow (less than 0.25 mm/s) tortuous flow through a Sephadex column. Furthermore, animal images show the technique to be feasible and quantitative in measuring rat brain microcirculation under normal, vasodilated (hypercarbia), and no-flow (post mortem) conditions.
Comparison of Blood Flow Rates and Hydraulic Resistance Between the Mahurkar Catheter, the Tesio Twin Catheter, and the Ash Split Cath (1998)

The Ash Split Cath (Medcomp, Harleysville, PA) is a recently introduced dual lumen permanent catheter designed to be placed through the internal jugular vein into the superior vena cava by single venipuncture technique. The transcutaneous portion is a 14 French cylindrically shaped catheter with D-shaped lumens and a Dacron (DuPont, Wilmington, DE) cuff. At the entrance to the jugular vein, the catheter splits into two separate D-shaped limbs that then merge into multiholed cylindrical tips in the vena cava. Split Caths (n = 10) have been placed in patients with end-stage renal disease and used for outpatient dialysis for approximately 2 months. Flow rates and hydraulic resistance have been compared with Mahurkar (Bard, Salt Lake City, UT) (n = 22) and Tesio (Medcomp) (n = 17) catheters in the same unit. Average blood flow rates (Qb) were 295 +/- 42 (SD) for Ash Split Caths vs 279 +/- 38 and 300 +/- 39 ml3/min for Mahurkar and Tesio catheters, respectively, and hydraulic resistances were 0.44 +/- 0.17, 0.52 +/- 0.15, and 0.56 +/- 0.11 mmHg/ml/min, respectively (not significant). No Split Caths have been removed for bleeding or flow complications. The Split Cath provides the simplicity of placement and removal of a single-bodied catheter with flow advantages of independent, cylindrical, multiholed tips.
Magnetization of Chiral Monolayers of Polypeptide: A Possible Source of Magnetism in Some Biological Membranes (2002)

α-Helicale l- und D-Polyalanine weisen in Form von selbstorganisierten Monoschichten auf Goldoberflächen magnetische Eigenschaften auf. Diese hängen von der Chiralität der Moleküle und der Richtung des Dipolmoments relativ zum Substrat ab. Die Orientierung der Moleküle relativ zur Oberfläche bei angelegtem Magnetfeld und die Spinselektivität beim Elektronentransport durch die Schichten wurden untersucht.
A Rapid Approach for Isobaric Peptide Termini Labeling (2012)

Isobaric peptide termini labeling (IPTL) is a recently introduced approach to the chemical labeling of peptides with isotopic reagents. Peptides derived from two different samples are labeled at the N terminus and at the C terminus with isotopically labeled reagents that have identical mass differences. To obtain isobaric peptides, labeling is carried out such that the introduced mass increase at one terminus will exactly match the mass decrease at the other terminus (and the other way around). This results in product ion spectra that display the quantitative difference of the peptide signal derived from the two samples for every b-ion and y-ion in the spectrum. The original IPTL approach required the selective modification of lysines followed by C-18 micropurification of modified peptides and reaction of the N termini. Here, we describe a new approach for IPTL that is based on the selective modification of the peptide N termini with succinic anhydride and subsequent reductive amination of C-terminal lysines with formaldehyde and cyanoborohydride. Both reactions can be carried out in one pot within 10 min and without C-18 micropurification. In addition, we present the software package IsobariQ for straightforward data analysis.
ON A CLASS OF CERTAIN ANALYTIC FUNCTIONS OF COMPLEX ORDER (1990)

We introduce a class, namely, $F_n(b,M)$ of certain analytic functions. For this class we detennine coefficient estimate, sufficient condition in terms of coefficients, maximization theonne concerning the coefficients, radius problem and a necessary and sufficient condition in terms of convolution. Our results generalize and correct some results of Nasr and Aouf ([2],[3]).
Quantitative Evaluation of Image-Based Distortion Correction in Diffusion Tensor Imaging (2004)

A statistical method for the evaluation of image registration for a series of images based on the assessment of consistency properties of the registration results is proposed. Consistency is defined as the residual error of the composition of cyclic registrations. By combining the transformations of different algorithms the consistency error allows a quantitative comparison without the use of ground truth, specifically, it allows a determination as to whether the algorithms are compatible and hence provide comparable registrations. Consistency testing is applied to evaluate retrospective correction of eddy current-induced image distortion in diffusion tensor imaging of the brain. In the literature several image transformations and similarity measures have been proposed, generally showing a significant reduction of distortion in side-by-side comparison of parametric maps before and after registration. Transformations derived from imaging physics and a three-dimensional affine transformation as well as mutual information (MI) and local correlation (LC) similarity are compared to each other by means of consistency testing. The dedicated transformations could not demonstrate a significant difference for more than half of the series considered. LC similarity is well-suited for distortion correction providing more consistent registrations which are comparable to MI.
Effect of thromboxane A2 inhibitors on allergic pulmonary inflammation in mice (1998)

Thromboxane (Tx)A2 synthase inhibitors and thromboxane prostanoid (TP) receptor antagonists have been developed as anti-asthma drugs. TxA2 may contribute to airflow limitation and bronchial hyperresponsiveness, and these compounds have been demonstrated to improve them. However, it is not known whether TxA2 is involved in bronchial inflammation. To address this question, we explored the influences of OKY-046 (a TxA2 synthase inhibitor) and S-1452 (a TP receptor antagonist) on eosinophilic inflammation of the airways using a murine model. BALB/c mice sensitized with ovalbumin and challenged by repeated exposure to ovalbumin yielded marked eosinophilia in bronchoalveolar lavage fluid (BALF). Treatment with either compound significantly reduced the number of total cells and eosinophils in BALF in a dose-dependent manner. The production of interleukin (IL)-5, IL-2 and interferon (IFN)-gamma by antigen-stimulated splenic mononuclear cells (SMNC) was significantly decreased in mice treated with either compound compared to that in untreated mice. Furthermore, both compounds inhibited proliferation and cytokine production of SMNC in vitro. These results suggest that both OKY-046 and S-1452 are capable of inhibiting production of cytokines, which in turn inhibits eosinophil infiltration into the murine airway. Thus, both thromboxane A2 synthesis inhibitors and thromboxane prostanoid antagonists may be effective as anti-inflammatory drugs in the treatment of asthma.
Compact and precise positioner based on the Inchworm principle (2000)

In this paper, we present a piezoelectric linear micropositioner. Its principle and configuration provide an elegant solution to confined positioning problems requiring compact systems. The developed device shows a high accuracy together with large travel ranges, due to a stepwise operation principle. A simple, low-cost realization process combined with an assembly step has been used to implement the device.
Therapeutic hypothermia for hypoxic–ischaemic encephalopathy in the newborn infant: review (2005)

In term infants with HIE there is emerging evidence that both selective head cooling and whole body cooling are neuroprotective and safe. This is consistent with a wealth of experimental animal data and adult trials. Neuroprotection seems to be lost if cooling is started after 6 h. The challenge now is to complete ongoing trials. If meta-analysis confirms a therapeutic effect, then this may lead to selection criteria and treatment protocols for very early hypothermia in HIE at term.