gebhart/patrepeval huggingface dataset:
MSC Frequency Correlates with Blood Vessel Density in Equine Adipose Tissue (2008)

Mesenchymal stem cells (MSCs) are multipotent cells that have the capacity to develop into different mature mesenchymal cell types. They were originally isolated from bone marrow, but MSC-like cells have also been isolated from other tissues. The common feature of all of these tissues is that they all house blood vessels. It is, thus, possible that MSCs are associated with perivascular locations. The objective of this work was to test the hypothesis that MSCs are associated with blood vessels by verifying if MSC frequency positively correlates with blood vessel density. To this end, samples from highly and poorly vascularized adipose tissue sites of two equine donors were collected and processed for histology and cell isolation. MSC frequency in these samples was estimated by means of CFU-F assays, which were performed under MSC conditions. Culture-adherent cells from equine adipose tissue and bone marrow were culture expanded, tested for differentiation into mesenchymal cell types in vitro, and implanted in vivo in porous ceramic vehicles to assess their osteogenic capacity, using human MSCs and brain pericytes as controls. The differentiation assays showed a difference between adipose tissue–derived cells as compared to equine bone marrow MSCs. While differences in CFU-F frequencies between both donors were evident, the CFU-F numbers correlated directly with blood vessel densities (r2 = 0.86). We consider these preliminary data as further evidence linking MSCs to blood vessels.
Covariance matrix tapers estimation in knowledge-aided STAP for sea clutter environment (2015)

In knowledge-aided space-time adaptive processing (KASTAP), a priori knowledge of the clutter covariance matrix is incorporated to enhance the radar detection performance in heterogeneous environment. In KA-STAP under sea clutter environment, the internal clutter motion (ICM) cannot be neglected, so it is necessary to estimate the covariance matrix taper (CMT) of the a priori covariance matrix according to real time clutter state. Traditionally, CMT is modelled as a singer function, which is not suitable in sea clutter environment for its lacking of adaptability. In this paper, we develop a CMT directly data estimation approach (DDE), where ICM information is extracted from training samples and used to construct CMT. By utilizing real time extracted information, the DDE CMT approach has the ability to cognitive time-varying sea clutter environment. Simulation results verify the effectiveness of the proposed CMT estimation approach.
An Optimal Algorithm for the Orienteering Tour Problem (1992)

Orienteering is a sport in which a competitor selects a path from a start to a destination, visiting control points along the path. Each control point has an associated score, and the travel between control points involves a certain cost. The problem is to select a set of control points to visit, so that the total score is maximized subject to a budget constraint on total cost. Several versions of this problem exist. In the version considered in this research, the start and the destination are the same, and the problem is to construct a subtour of the set of control points. The orienteering problem is a variant of the traveling salesman problem, and arises in vehicle routing and production scheduling situations. This problem has been shown to be NP-hard in the literature. We develop an optimal algorithm to solve this problem, using Lagrangean relaxation within a branch-and-bound framework. The Lagrangean relaxation is solved by a degree-constrained spanning tree procedure. Characteristics of the Lagrangean relaxation are studied, and several implementation features to improve the performance of the algorithm are presented. Detailed computational results for problems having up to 150 control points are presented. The results show that the proposed approach is viable for solving problems of medium to large size. INFORMS Journal on Computing, ISSN 1091-9856, was published as ORSA Journal on Computing from 1989 to 1995 under ISSN 0899-1499.
The Structural Response of Cylindrical Shells to Internal Shock Loading (1999)

The internal shock loading of cylindrical shells can be represented as a step load advancing at constant speed. Several analytical models are available to calculate the structural response of shells to this type of loading. These models show that the speed of the shock wave is an important parameter. In fact, for a linear model of a shell of infinite length, the amplitude of the radial deflection becomes unbounded when the speed of the shock wave is equal to a critical velocity. It is evident that simple (static) design formulas are no longer accurate in this case. The present paper deals with a numerical and experimental study on the structural response of a thin aluminum cylindrical shell to shock loading. Transient finite element calculations were carried out for a range of shock speeds. The results were compared to experimental results obtained with the GALCIT 6-in. shock tube facility. Both the experimental and the numerical results show an increase in amplitude near the critical velocity, as predicted by simple steady-state models for shells of infinite length. However, the finite length of the shell results in some transient phenomena. These phenomena are related to the reflection of structural waves and the development of the deflection profile when the shock wave enters the shell.
Capillary gas‐liquid chromatography of bile acids: Improvement with on‐column injection (1978)

Abstract Analysis of trimethylsilylethers of methyl esters of bile acids exhibits high separation efficiency with a 20 m × 0.3 mm glass capillary column covered with a crystal layer of barium carbonate and coated with polyethyleneglycol 20000 as liquid phase [3]. The sensitivity and reproducibility of this method can be further improved by an on‐column injection technique according to Grob et al. [4].
Standardization of HER2 Immunohistochemistry in Breast Cancer by Automated Quantitative Analysis (2009)

These data demonstrate that AQUA analysis can provide a standardized HER2 immunohistochemistry test that can meet current guidelines by the American Society of Clinical Oncology/College of American Pathologists. The use of AQUA analysis could allow for standardized and objective HER2 testing in clinical laboratories.
Hormone Response Domains in Gene Transcription (1992)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
A Combined Experimental-Computational Study on the Effect of Topology on Carbon Dioxide Adsorption in Zeolitic Imidazolate Frameworks (2012)

We report CO2 adsorption data for four zeolitic imidazolate frameworks (ZIFs) to 55 bar, namely ZIF-7, ZIF-11, ZIF-93, and ZIF-94. Modification of synthetic conditions allows access to different topologies with the same metal ion and organic link: ZIF-7 (ZIF-94) having sod topology and ZIF-11 (ZIF-93) having the rho topology. The varying topology, with fixed metal ion and imidazolate functionality, makes these systems ideal for studying the effect of topology on gas adsorption in ZIFs. The experiments show that the topologies with the smaller pores (ZIF-7 and 94) have larger adsorptions than their counterparts (ZIF-11 and 93, respectively) at low pressures (<1 bar); however, the reverse is true at higher pressures where the larger-pore structures have significantly higher adsorption. Molecular modeling and heat of adsorption measurements indicate that while the binding potential wells for the smaller-pore structures are deeper than those of the larger-pore structures, they are relatively narrow and cannot accommodate multiple CO2 occupancy, in contrast to the much broader potential wells seen in the larger pore structures.
A monoclonal antibody to the Ca<sup>2+</sup> ‐ATPase of cardiac sarcoplasmic reticulum cross‐reacts with slow type I but not with fast type II canine skeletal muscle fibers: An immunocytochemical and immunochemical study (1988)

Ca2+-ATPase of the sarcoplasmic reticulum was localized in cryostat sections from three different adult canine skeletal muscles (gracilis, extensor carpi radialis, and superficial digitalis flexor) by immunofluorescence labeling with monoclonal antibodies to the Ca2+-ATPase. Type I (slow) myofibers were strongly labeled for the Ca2+-ATPase with a monoclonal antibody (II D8) to the Ca2+-ATPase of canine cardiac sarcoplasmic reticulum; the type II (fast) myofibers were labeled at the level of the background with monoclonal antibody II D8. By contrast, type II (fast) myofibers were strongly labeled for Ca2+-ATPase of rabbit skeletal sarcoplasmic reticulum. The subcellular distribution of the immunolabeling in type I (slow) myofibers with monoclonal antibody II D8 corresponded to that of the sarcoplasmic reticulum as previously determined by electron microscopy. The structural similarity between the canine cardiac Ca2+-ATPase present in the sarcoplasmic reticulum of the canine slow skeletal muscle fibers was demonstrated by immunoblotting. Monoclonal antibody (II D8) to the cardiac Ca2+-ATPase binds to only one protein band present in the extract from either cardiac or type I (slow) skeletal muscle tissue. By contrast, monoclonal antibody (II H11) to the skeletal type II (fast) Ca2+-ATPase binds only one protein band in the extract from type II (fast) skeletal muscle tissue. These immunopositive proteins coelectrophoresed with the Ca2+-ATPase of the canine cardiac sarcoplasmic reticulum and showed an apparent Mr of 115,000. It is concluded that the Ca2+-ATPase of cardiac and type I (slow) skeletal sarcoplasmic reticulum have at least one epitope in common, which is not present on the Ca2+-ATPase of sarcoplasmic reticulum in type II (fast) skeletal myofibers. It is possible that this site is related to the assumed necessity of the Ca2+-ATPase of the sarcoplasmic reticulum in cardiac and type I (slow) skeletal myofibers to interact with phosphorylated phospholamban and thereby enhance the accumulation of Ca2+ in the lumen of the sarcoplasmic reticulum following beta-adrenergic stimulation.
The Relationship between the Initial Gas Ratios and the Condensed Phase Composition in the CVD of B<sub>x</sub>C with BCl<sub>3</sub>-CH<sub>4</sub>-H<sub>2</sub> Precursors (2011)

For the preparation of the self-healing phase B x C with BCl 3 -CH 4 -H 2 precursors, the production has been examined as a function of the initial gas ratios of BCl 3 /(BCl 3 +CH 4 ) and H 2 /(BCl 3 +CH 4 ) at given temperature and pressure. The results show that the composition of the condensed phase is quite sensitive to the molar ratio of BCl 3 /(BCl 3 +CH 4 ) and H 2 /(BCl 3 +CH 4 ). The ideal condition for the deposition of B x C is that the ratio of BCl 3 /(BCl 3 +CH 4 ) is 0.8 and the H 2 /(BCl 3 +CH 4 ) ratio ranges from 10 to 10 5.2 . The carbon or boron-rich material is mainly controlled by the ratios of BCl 3 /(BCl 3 +CH 4 ) and H 2 /(BCl 3 +CH 4 ). The deposition condition of carbon-rich phase should be in low BCl 3 /(BCl 3 +CH 4 ) (0.0~0.8) and H 2 /(BCl 3 +CH 4 ) (10 -2 <10 2 ) ratios, whereas that of the boron-rich phase needs high BCl 3 /(BCl 3 +CH 4 ) (0.8~1.0) and H 2 /(BCl 3 +CH 4 ) (10 4 ~10 5 ) ratios.
Interviews: A C++ graphical interface toolkit (1988)

We have implemented an object-oriented user interface package, called InterViews, that supports the composi-tion of a graphical user interface from a set of inter-active objects. The base class for interactive objects, called an interactor, and base class for composite ob-jects, called a scene, define a protocol for combining interactive behaviors. Subclasses of scene define com-mon types of composition: a box tiles its components, a tray allows components to overlap or constrain each other’s placement, a deck stacks its components so that only one is visible, a frame adds a border, and a view-port shows part of a component. Predefined compo-nents include menus, scrollers, buttons, and text editors. InterViews also includes classes for structured text and graphics. InterViews is written in C++ and runs on top of the X window system. 1
Investigation of graded index SiO<sub>x</sub>N<sub>y</sub> antireflection coating for silicon solar cell manufacturing (2007)

Abstract An optimization of SiO x N y anti‐reflective coatings with graded index layers for silicon solar cells based on the Bruggeman's effective medium approximation is presented. For simulation of reflectance and absorption of graded layer, the experimental optical data of silicon nitride SiN x :H and oxynitride SiO x N y obtained by Low Frequency (440 kHz) Plasma Enhanced Chemical Vapour Deposition (LF‐PECVD) were used. We have shown that the graded index oxynitride antireflection coating can reduce the effective reflectance to about 2.5% but the high absorption due to high extinction coefficient compensates this improvement and reduces the short circuit current (J sc ) of the solar cell. The improvement in the J sc can be obtained for graded SiN x O y layer with smaller value of refractive index of SiN x ( n = 2.2). In this case the graded SiO x N y layer is characterized by an abrupt concentration profile and can be considered as a double antireflection coating SiO 2 /SiN x . (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Dual-gate operation and volume inversion in n-channel SOI MOSFET's (1992)

The effects of volume inversion in thin-film short-channel SOI MOSFETs and the efficacy of dual-gate operation in enhancing their device performance have been analyzed using two-dimensional device simulations and one-dimensional analytical computations. The analyses have been restricted to the strong inversion regime, which is the practically useful region of operation of the SOI MOSFETs. In this region, the analyses suggest that when compared at constant V/sub G/-V/sub T/ values, the dual-channel volume inverted devices do not offer significant current-enhancement advantage, other than that expected from the second channel, over the conventional single-channel devices for silicon thicknesses in the 0.1- mu m range.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Querying Data Providing Web Services (2010)

Web services are often used for search computing where data is retrieved from servers providing information of different kinds. Such data providing web services return a set of objects for a given set of parameters without any side effects. There is need to enable general and scalable search capabilities of data from data providing web services, which is the topic of this Thesis. The Web Service MEDiator (WSMED) system automatically provides relational views of any data providing web service operations by reading the WSDL documents describing them. These views can be queried with SQL. Without any knowledge of the costs of executing specific web service operations the WSMED query processor automatically and adaptively finds an optimized parallel execution plan calling queried data providing web services. For scalable execution of queries to data providing web services, an algebra operator PAP adaptively parallelizes calls in execution plans to web service operations until no significant performance improvement is measured, based on monitoring the flow from web service operations without any cost knowledge or extensive memory usage. To comply with the Everything as a Service (XaaS) paradigm WSMED itself is implemented as a web service that provides web service operations to query and combine data from data providing web services. A web based demonstration of the WSMED web service provides general SQL queries to any data providing web service operations from a browser. WSMED assumes that all queried data sources are available as web services. To make any data providing system into a data providing web service WSMED includes a subsystem, the web service generator, which generates and deploys the web service operations to access a data source. The WSMED web service itself is generated by the web service generator.
Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity (1976)

Abstract Colchicine resistant (CH R ) mutants of CHO cells with reduced permeability to colchicine display extensive cross‐resistance to a number of apparently unrelated compounds including puromycin, daunomycin, emetine, ethidium bromide and gramicidin D. A positive correlation was observed between the level of cross‐resistance and the relative hydrophobicity of these compounds. The mutants also showed increased (collateral) sensitivity to local anaesthetics (procaine, tetracaine, xylocaine and propanolol), steroid hormones (1‐dehydrotestosterone, corticosterone and 5β‐pregnan‐3,20‐dione) and some Triton × compounds. In general, the degree of the pleiotropic response (cross‐resistance or collateral sensitivity) correlated with the degree of colchicine resistance in mutant lines. These results are consistent with the pleiotropic phenotype being the result of the same mutation(s) which confer colchicine resistance and support a model for resistance in which the reduced permeability is assumed to be the result of an alteration in the modulation of the fluidity of the surface membrane.
Deficiency of Interleukin-1 Receptor Antagonist Promotes Neointimal Formation After Injury (2003)

The absence of IL-1Ra promotes neointimal formation in mice after injury. These results suggest that endogenous IL-1Ra may suppress other occlusive vascular responses to injury, such as atherosclerosis and restenosis after angioplasty.
Object tracking by adaptive modeling (2002)

This paper addresses the problem of object tracking in image sequences. The approach taken is based upon adaptive statistical models. An object selected in a frame by a user is tracked throughout the sequence by using a blob-like description of its features. The object features are continuously updated by using the on-line version of the expectation-maximization algorithm. The proposed object description results in a flexible representation.
Inhibitory effect of sesamin on ivabradine metabolism in rats. (2020)

In this work, the aim of our study was to assess whether sesamin could influence the pharmacokinetics of ivabradine and its active metabolite N-desmethylivabradine in rats. At the begining, 12 healthy male Sprague-Dawley rats were randomly divided into two groups: The rats were received an oral administration of 1.0mg/kg ivabradine alone (the control group), and the rats were given 1.0mg/kg ivabradine co-administered with 50mg/kg sesamin by gavage (the test group). After that, blood samples were collected from the tail vein of rats, and ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) were used for determing the plasma concentrations of ivabradine and N-desmethylivabradine in rats. Finally, the pharmacokinetic parameters were estimated using DAS 2.0 software. As the results, the pharmacokinetic parameters (t<sub>1/2</sub>, C<sub>max</sub>, AUC <sub>(0-t)</sub> and AUC <sub>(0-oo)</sub>) of ivabradine in the control group were significantly lower than those in the test group (P<0.05). Moreover, sesamin significantly decreased t<sub>1/2</sub>, C<sub>max</sub>, AUC<sub>(0-t)</sub> and AUC<sub>(0-oo)</sub> of N-desmethylivabradine when compared to the control. These results demonstrated that sesamin increases plasma concentration of ivabradine and decreases N-desmethylivabradine conversely. Hence, our data indicated sesamin could influence the pharmacokinetic profile of ivabradine in rats, which might cause food-drug interaction in humans.
Development of magnetic anchoring and guidance systems for minimally invasive surgery (2010)

Recent advances in urology have included natural orifice translumenal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS). These techniques seek to minimize morbidity by reducing the number of transabdominal port sites, but this comes at a cost of decreased instrument agility and other technical challenges that have prevented LESS and NOTES from entering mainstream urologic practice. Magnetic anchoring and guidance systems (MAGS) consist of instruments that are inserted laparoscopically through an entry in the peritoneal cavity at one point and then driven into position elsewhere and controlled with magnets. These instruments improve the ergonomics of minimally invasive surgery and may help make LESS and NOTES more accessible to urologists across experience levels.
Amine-impregnated silica monolith with a hierarchical pore structure: enhancement of CO2 capture capacity (2009)

A polyethylenimine-impregnated hierarchical silica monolith exhibited significantly higher CO(2) capturing capacity than other silica-supported amine sorbents, and produced a reversible and durable sorption performance.
Establishment of Spontaneously Immortalized Keratinocyte Lines from Wild-Type and Mutant Mice (2009)

A considerable number of transgenic or knockout mice in which epidermal keratinocytes have been targeted die shortly after birth due to barrier defects. In this case, recovery and cultivation of keratinocytes from these animals provide an opportunity for in vitro studies. Working with isolated keratinocytes is also interesting for certain experiments which cannot be performed in live animals. Primary human keratinocytes can be kept in culture for a variable number of passages and then senescence. Immortalization can be achieved by transduction with constructs encoding viral genes. Murine keratinocytes can be kept in culture as primary cells. Naturally the numbers of cells obtained by direct isolation from mouse epidermis is restricted and sometimes not sufficient for certain biochemical analyses. To overcome this restriction some permanent murine keratinocyte lines have been generated by transfection with SV40T or HPV E6E7 genes. This is, however, not suitable if established or hypothetical biochemical links exist between these genes and the pathways or processes to be analysed in the respective experiment. We describe an easy and reproducible method of establishing permanent keratinocyte lines from spontaneously immortalized primary murine keratinocytes. This method employs co-cultivation of keratinocytes with 3T3-J2 fibroblast feeder cells for several passages during which immortalization occurs. The resulting keratinocyte lines do not only grow infinitely but, in many cases, individual lines from the same genetic background also exhibit similar growth characteristics, hence they are especially valuable for comparative studies.
19th International Conference on VLSI Design : held jointly with 5th International Conference on Embedded Systems Design : 3-7 January, 2005 [i.e.2006], Hyderabad, India (2005)

This proceedings volume contains 136 thouroughly reviewed papers from joint conferences held January 2005: the 19th International Conference on VLSI Design and the 5th International Conference on Embedded Systems Design. The papers describe recent work in analog and mixed-signal design, VLSI technology, interconnect design, test and diagnosis, comm