gebhart/patrepeval huggingface dataset:
Mechanism of the SDS-resistant Synaptotagmin Clustering Mediated by the Cysteine Cluster at the Interface between the Transmembrane and Spacer Domains (2001)

Synaptotagmin I (Syt I), a proposed major Ca(2+) sensor in the central nervous system, has been hypothesized as functioning in an oligomerized state during neurotransmitter release. We previously showed that Syts I, II, VII, and VIII form a stable SDS-resistant, beta-mercaptoethanol-insensitive, and Ca(2+)-independent oligomer surrounding the transmembrane domain (Fukuda, M., and Mikoshiba, K. (2000) J. Biol. Chem. 275, 28180-28185), but little is known about the molecular mechanism of the Ca(2+)-independent oligomerization by the synaptotagmin family. In this study, we analyzed the Ca(2+)-independent oligomerization properties of Syt I and found that it shows two distinct forms of self-oligomerization activity: stable SDS-resistant self-oligomerization activity and relatively unstable SDS-sensitive self-oligomerization activity. The former was found to be mediated by a post-translationally modified (i.e. fatty-acylated) cysteine (Cys) cluster (Cys-74, Cys-75, Cys-77, Cys-79, and Cys-82) at the interface between the transmembrane and spacer domains of Syt I. We also show that the number of Cys residues at the interface between the transmembrane and spacer domains determines the SDS- resistant oligomerizing capacity of each synaptotagmin isoform: Syt II, which contains seven Cys residues, showed the strongest SDS-resistant oligomerizing activity in the synaptotagmin family, whereas Syt XII, which has no Cys residues, did not form any SDS-resistant oligomers. The latter SDS-sensitive self-oligomerization of Syt I is mediated by the spacer domain, because deletion of the whole spacer domain, including the Cys cluster, abolished it, whereas a Syt I(CA) mutant carrying Cys to Ala substitutions still exhibited self-oligomerization. Based on these results, we propose that the oligomerization of the synaptotagmin family is regulated by two distinct mechanisms: the stable SDS-resistant oligomerization is mediated by the modified Cys cluster, whereas the relatively unstable (SDS-sensitive) oligomerization is mediated by the environment of the spacer domain.
Polarizer-free liquid crystal display with electrically switchable microlens array (2013)

We propose a polarizer-free liquid crystal display (LCD) with an electrically switchable microlens array. The incident lights are controlled to focused or defocused states by index matching of the lens polymer and LC layer. By adopting two light-blocking masks that have a circular stop pattern and the complementary open pattern, the LCD was able to realize the entire gray scale. Additionally, to achieve fast response time characteristics, we introduce polymerized RMs within the alignment layers.
Ion-beam-induced densification of sol-gel ceramic thin films (1994)

Ion-beam-induced densification of sol-gel zirconia thin films is examined here. Ion irradiation of sol-gel zirconia films leads to microstructural and chemical changes (densification) in the films. Ion beam analysis indicates the loss of carbon, hydrogen, and oxygen as a result of implantation. Oxygen:zirconium ratios less than that predicted for stoichiometric ZrO2 for the higher dose implanted films were observed. The chemical and microstructural modifications were attributed to both electronic interactions and nuclear collisions between the energetic ions and the target atoms. Densification of only a near-surface region of a sol-gel zirconia thin film proved that the effects of beam heating on the observed densification are minimal.
Hypervelocity impact testing of materials for additive construction: Applications on Earth, the Moon, and Mars (2017)

The National Aeronautics and Space Administration’s Additive Construction with Mobile Emplacement project is investigating the building of infrastructure elements on planetary surfaces by 3-dimensional printing with construction materials made of in-situ resources. Likewise, the United States Army Corps of Engineers’ Additive Construction of Expeditionary Structures project seeks to 3-dimensionally print structures made of concrete available everywhere on Earth. These construction materials must resist failure due to micrometeorite impact and ballistic impact, respectively. Samples were tested for resistance to hypervelocity impact with a 2.0mm aluminum sphere at a velocity of 7.00±0.2km/s. Ordinary Portland Cement-bearing samples were not perforated and did not spall, including the sample that was additively constructed. This indicates printed construction material can withstand impact. The Sorel cement sample was not perforated, but fractured and spalled. Thus, Sorel cement in its current formulation would not be considered a feasible construction material for planetary structures.
Thalidomide in luminal and fistulizing Crohn's disease resistant to standard therapies (2007)

Thalidomide is an effective short- to medium-term treatment in selected patients with refractory luminal and fistulizing Crohn's disease. Its long-term use is limited by toxicity.
A randomized, double‐blind, placebo‐controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee (2002)

As a symptom modifier in OA patients with a wide range of pain severities, glucosamine sulphate was no more effective than placebo.
Isolation of Proteolytic Enzymes from Solution as Dry Stable Derivatives of Cellulosic Ion Exchangers (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation of Proteolytic Enzymes from Solution as Dry Stable Derivatives of Cellulosic Ion ExchangersM. A. Mitz and R. J. SchlueterCite this: J. Am. Chem. Soc. 1959, 81, 15, 4024–4028Publication Date (Print):August 1, 1959Publication History Published online1 May 2002Published inissue 1 August 1959https://pubs.acs.org/doi/10.1021/ja01524a052https://doi.org/10.1021/ja01524a052research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the production and use of the optical contact bond (1964)

The production and use of optical contact bonds including glass to glass and glass to fragile evaporated thin films is discussed. These bonds have freedom from chemical contamination and from uncertainty in mechanical location; they are permanent under normal conditions but may be dismantled for maintenance if necessary.
Nucleic Acid Homologies in the Genus Pseudomonas (1973)

On the basis of ribosomal ribonucleic acid homologies, the genus Pseudomonas can be divided into at least five distinct groups, some of which are as distantly related to each other as they are to Escherichia coli. One of these groups contains members of the genus Xanthomonas. The data presented support and extend the previous grouping based on deoxyribonucleic acid homologies and support the current view that the portion of the genome coding for ribosomal ribonucleic acid is more conserved in the course of evolution than the bulk of the genome.
Evaluation and Treatment of Organic and Inorganic Deposition in the Midway Sunset Field, Kern County, California (1990)

ABSTRACT The Midway Sunset Field is the 2nd largest oil producing-field in the state of California. Current production is approximately 155,000 barrels of oil per day -from 9,200 wells. Due to variable productivity exhibited by wells in this field, an extensive study was conducted to determine potential production impairment mechanisms. This study was accomplished by analyzing cores, produced fluids and the organic deposition found in and around the slots of liners pulled from two wells. The reduced productivity exhibited by these wells was determined to be due primarily to the deposition of organic and inorganic components in the liner slots. This deposition can be associated with the asphaltic properties of the crude, the unconsolidated nature of the formations and the use of Thermal Enhanced Oil Recovery techniques. Quantitative and qualitative studies were performed to evaluate the damage and generate an operationally feasible and cost effective treatment. This investigation resulted in the design of a unique treatment and placement technique. Production response is presented from 35 wells included in this ongoing stimulation program. Candidate selection criteria and related stimulation performance are also discussed.
Inter-block GPU communication via fast barrier synchronization (2010)

While GPGPU stands for general-purpose computation on graphics processing units, the lack of explicit support for inter-block communication on the GPU arguably hampers its broader adoption as a general-purpose computing device. Interblock communication on the GPU occurs via global memory and then requires barrier synchronization across the blocks, i.e., inter-block GPU communication via barrier synchronization. Currently, such synchronization is only available via the CPU, which in turn, can incur significant overhead. We propose two approaches for inter-block GPU communication via barrier synchronization: GPU lock-based synchronization and GPU lock-free synchronization. We then evaluate the efficacy of each approach via a micro-benchmark as well as three well-known algorithms - Fast Fourier Transform (FFT), dynamic programming, and bitonic sort. For the micro-benchmark, the experimental results show that our GPU lock-free synchronization performs 8.4 times faster than CPU explicit synchronization and 4.0 times faster than CPU implicit synchronization. When integrated with the FFT, dynamic programming, and bitonic sort algorithms, our GPU lock-free synchronization further improves performance by 10%, 26%, and 40%, respectively, and ultimately delivers an overall speed-up of 70x, 13x, and 24x, respectively.
The Utility of Arbekacin in Patients with Methicillin-Resistant Staphylococcus aureus Infection (1998)

Many reports describing the utility of vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) infection have been published, while there have only been a few concerning arbekacin (ABK), an aminoglycoside developed in Japan. In the present study, the efficacy of this drug was assessed in 11 patients with MRSA infections (2 with sepsis and 9 with pneumonia) who were admitted to the Emergency Center, Showa Universtiy Fujigaoka Hospital. ABK was administered by intravenous infusion over 60 minutes at doses of 50, 100, 200, and 400 mg 1 to 4 times daily, and blood was collected at various times after administration. ABK was found to be ineffective in all patients at doses of 50 and 100 mg, but was effective against pneumonia at a dose of only 200 mg. However, ABK was effective against both pneumonia and sepsis at a dose of 400 mg. We conclude that ABK has a dose-dependent anti-MRSA effect. When the postantibiotic effect, first-exposure effect, and other factors are considered, ABK is best administered once daily rather than in small, more frequent doses. However, with the once-daily regimen, therapeutic drug monitoring is necessary to prevent adverse reactions.
Coking Kinetics of Asphaltenes as a Function of Chemical Structure (2003)

The dependence of coking kinetics on the chemical structure of asphaltenes was examined by reacting five different asphaltenes in 1-methylnaphthalene and tetralin at 430 °C and ca. 9.8 MPa. The selected heptane-insoluble asphaltenes were Athabasca asphaltenes from Canada, Arabian Light and Arabian Heavy from Saudi Arabia, Maya from Mexico, and Gudao from China. The 13C NMR aromaticity of the asphaltenes ranged from 0.40 to 0.61, and the sulfur contents ranged from 4.44 wt % to 7.47 wt %. The cracking kinetics of the asphaltenes were consistent with a modified kinetic model for coke formation, incorporating phase separation and hydrogen transfer to the asphaltenes. The rate of cracking of asphaltenes in 1-methylnaphthalene correlated with the content of aliphatic sulfur, and the yield coefficient for coke correlated with the aromaticity. These correlations allowed prediction of coking kinetics for Iranian Light and Khafji asphaltenes on the basis of average structural properties of asphaltenes. Hydrogen transfer to the different asphaltenes did not correlate with any single average structural property.
Temporal abstract interpretation (2000)

We study the abstract interpretation of temporal calculi and logics in a general syntax, semantics and abstraction independent setting. This is applied to the @@@@-calculus, a generalization of the μ-calculus with new reversal and abstraction modalities as well as a new time-symmetric trace-based semantics. The more classical set-based semantics is shown to be an abstract interpretation of the trace-based semantics which leads to the understanding of model-checking and its application to data-flow analysis as incomplete temporal abstract interpretations. Soundness and incompleteness of the abstractions are discussed. The sources of incompleteness, even for finite systems, are pointed out, which leads to the identification of relatively complete sublogics, à la CTL.
Isothiocyanates in the chemistry of heterocycles (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsothiocyanates in the chemistry of heterocyclesArya K. Mukerjee and Ram. AshareCite this: Chem. Rev. 1991, 91, 1, 1–24Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/cr00001a001https://doi.org/10.1021/cr00001a001research-articleACS PublicationsRequest reuse permissionsArticle Views3423Altmetric-Citations298LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Calculation for fluorescence modulation by absorbing species and its application to measurements using optical fibers (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCalculation for fluorescence modulation by absorbing species and its application to measurements using optical fibersPing. Yuan and David R. WaltCite this: Anal. Chem. 1987, 59, 19, 2391–2394Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/ac00146a015https://doi.org/10.1021/ac00146a015research-articleACS PublicationsRequest reuse permissionsArticle Views665Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hearing aid gain prescriptions balance restoration of auditory nerve mean-rate and spike-timing representations of speech (2008)

Linear and nonlinear amplification schemes for hearing aids have thus far been developed and evaluated based on perceptual criteria such as speech intelligibility, sound comfort, and loudness equalization. Finding amplification schemes that optimize all of these perceptual metrics has proven difficult. Using a physiological model, Bruce et al. [1] investigated the effects of single-band gain adjustments to linear amplification prescriptions. Optimal gain adjustments for model auditory-nerve fiber responses to speech sentences from the TIMIT database were dependent on whether the error metric included the spike timing information (i.e., a time-resolution of several microseconds) or the mean firing rates (i.e., a time-resolution of several milliseconds). Results showed that positive gain adjustments are required to optimize the mean firing rate responses, whereas negative gain adjustments tend to optimize spike timing information responses. In this paper we examine the results in more depth using a similar optimization scheme applied to a synthetic vowel /E/. It is found that negative gain adjustments (i.e., below the linear gain prescriptions) minimize the spread of synchrony and deviation of the phase response to vowel formants in responses containing spike-timing information. In contrast, positive gain adjustments (i.e., above the linear gain prescriptions) normalize the distribution of mean discharge rates in the auditory nerve responses. Thus, linear amplification prescriptions appear to find a balance between restoring the spike-timing and mean-rate information in auditory-nerve responses.
Group Key Management Scheme Based on Proxy Re-cryptography for Near-Space Network (2011)

The Near-Space Network has gotten more and more attentions and become a new research focus with the rapidly development of space information system recently. It is a large network with characteristics of high exposure, dynamic topology, heterogeneous network, etc. The requirement of security for group communications system is much stronger. A group key management scheme based on the hierarchical and domain structure of Near-Space Network is proposed. The proxy re-cryptography algorithm is used in the rekeying process, which solves the problem of a single point of failure thoroughly. Rekeying algorithm for group members' switching between domains is designed and can efficaciously reduce the rekeying overhead caused by switch actions of high speed nodes. The performance analysis shows that the proposed scheme is a secure and reliable group key management scheme for near-space network.
Use of Cyclosporine 0.05% Ophthalmic Emulsion for Contact Lens–Intolerant Patients (2006)

The results of this pilot study indicate that cyclosporine 0.05% is beneficial for contact lens wearers with dry eye and reduces contact lens intolerance.
An Evaluation of the Cascaded H-Bridge Multilevel Inverter Topology For Direct-Drive Synchronous Wind Farm Applications (2006)

A key driver in the recent success of wind has been engineering advances that have lead to improved economics. Many of these advances have centered on power electronic converters, which feature a rectifier that converts the uncontrolled alternating current output of a wind generator to direct current, and an inverter, which converts that direct current back to a controlled alternating current synchronized with the power grid to which the wind generator is connected. Most of the inverters on today’s market use the full-bridge topology, which features six power electronic switches per wind turbine. The purpose of this thesis is to investigate if the cascaded H-bridge multilevel inverter offers benefit in terms of improved economics. Potential advantages of the cascaded H-bridge inverter include reduced switch count, improved converter efficiency, and simplified interconnection to the utility. Potential drawbacks include an increase in required power electronic switch ratings and a reduced ability to withstand transient wind conditions. This thesis concludes that certain control schemes can address performance under transient wind (and thus power production) conditions and that improvements in converter efficiency and reduction in switch counts are offset by increased switch requirements. Therefore, any benefit to justify the use of the cascaded H-bridge inverter in wind farms will arise from a simplified point of common connection to the utility.
Production of Polysaccharide by Culinary-Medicinal Mushroom Agaricus brasiliensis S. Wasser et al. LPB 03 (Agaricomycetideae) in Submerged Fermentation and Its Antitumor Effect (2003)

Studies were performed on the production of extracellular polysaccharide in submerged culture of Agaricus brasiliensis Wasser et al. and the effects of different carbon and nitrogen sources individually and in combinations on production. The polysaccharide produced was evaluated for its antitumor action against Sarcoma 180. Glucose and yeast extract gave the best combination of carbon and nitrogen sources for the polysaccharide production. The biomass yield and polysaccharide produced were 222.3 and 10.867 mg/50 mL (dry wt), respectively, at the concentration of 20 g/L glucose and 2 g/L yeast extract with the medium containing MgSO4Ч7H2O (0.1%) and K2HPO4Ч3H2O (0.1%) at pH 6.0 and 32°C after the 9 days' static cultivation. The extracellular polysaccharide showed strong antitumor activity against Sarcoma 180. Complete regression ratio of 50% and suppression ratio percentage of 72.19% were observed.