gebhart/patrepeval huggingface dataset:
Spontaneous Regression of Grade 3 Vulvar Intraepithelial Neoplasia Associated with Human Papillomavirus-16–Specific CD4+ and CD8+ T-Cell Responses (2004)

Cell-mediated immunity directed against human papillomavirus 16 (HPV-16) antigens was studied in six patients affected with grade 3 vulvar intraepithelial neoplasia (VIN3, also known as bowenoid papulosis). Five of the patients presented with a chronic and persistent disease that relapsed after destructive treatments. They showed no detectable anti-HPV blood T-cell responses and no T-cell intraepidermal vulvar infiltrate containing both CD4+ and CD8+ lymphocytes. The last patient had a complete clearance of viral lesions, 8 months after disease onset and 2 months after electrocoagulation of <50% of the VIN3 lesions. She showed high frequency anti-E6 and anti-E7 effector blood T cells by ex vivo ELISpot-IFNgamma assay before clinical regression. Immunohistochemical study of her vulvar biopsy revealed a marked dermal infiltrate containing a majority of CD4+ T lymphocytes and an epidermal infiltrate made up of both CD4(+) and CD8(+) T cells. This seems to be the first evidence of an association between spontaneous regression of VIN3 lesions and HPV-specific T-cell responses detectable in the blood. Hence, an increase of HPV-specific effector T lymphocyte responses by vaccine-based therapeutic strategies might be useful to clear the lesions in bowenoid papulosis disease.
Breast Reconstruction with SGAP and IGAP Flaps (2010)

Perforator flaps allow for safe, reliable tissue transfer from a variety of sites and provide ideal tissue for breast reconstruction, with minimal donor-site morbidity.
An Agent-Based Model For Web Services Transaction Processing (2005)

As Web services are getting wider deployment, Web services transaction processing (WSTP) are getting more and more attentions. There is a strong requirement for searching a new formal model to describe and reason about WSTP. This paper reports one of the results of the work that examine the WST from the perspective of intelligent agents, which aims to enable WSTP by agents over heterogeneous platforms that can negotiate to initiate and perform WSTP by coordination. Based on the investigation of existing WSTP models, an agent-based WSTP model (AWM) is proposed which covers most of the features but is more abstract and generic. An WSTP implementation model is proposed based on AWM. We believe that the AWM model and implementation model contributes to the design and development WSTP using agents, and can integrate WSTP which use different protocols on heterogeneous platforms.
Adaptive lattice noise canceller and optimal step size (2005)

The lattice-structured adaptive noise canceller has been studied: a brief formula about the relation of its misadjustment to the step size and the number of stages has been found theoretically and checked experimentally, showing that the misadjustment increases exponentially with the number of stages, an optimized step size has been applied to multi-stage lattice filter, with drastic reduction in convergence time.
Extinction-ratio-independent method for chirp measurements of Mach-Zehnder modulators (2004)

The authors describe a general method to extract the frequency chirping of Mach-Zehnder modulators based on direct measurements of the output spectrum. This method is independent of the modulator extinction ratio and allows measurement of the intrinsic chirp parameter to an accuracy of 5%.
Conservation of a Triple-Helix-Forming RNA Stability Element in Noncoding and Genomic RNAs of Diverse Viruses (2012)

Abundant expression of the long noncoding (lnc) PAN (polyadenylated nuclear) RNA by the human oncogenic gammaherpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) depends on a cis-element called the expression and nuclear retention element (ENE). The ENE upregulates PAN RNA by inhibiting its rapid nuclear decay through triple-helix formation with the poly(A) tail. Using structure-based bioinformatics, we identified six ENE-like elements in evolutionarily diverse viral genomes. Five are in double-stranded DNA viruses, including mammalian herpesviruses, insect polydnaviruses, and a protist mimivirus. One is in an insect picorna-like positive-strand RNA virus, suggesting that the ENE can counteract cytoplasmic as well as nuclear RNA decay pathways. Functionality of four of the ENEs was demonstrated by increased accumulation of an intronless polyadenylated reporter transcript in human cells. Identification of these ENEs enabled the discovery of PAN RNA homologs in two additional gammaherpesviruses, RRV and EHV2. Our findings demonstrate that searching for structural elements can lead to rapid identification of lncRNAs.
Laser Excited Broadside Acoustic Array (1973)

A high-power modulated laser beam in a fluid acts like a broadside acoustic directional array at the modulation frequency. The laser is assumed to generate a beam having average power P0 with 100% modulation at the frequency ω. The radiated acoustic intensity I at a distance r far from this source is I = (αβωP0)232ρ0c0(πrcp)2 [1α2+k2 cos2θ], in which, α is the intensity attenuation coefficient for the laser beam, θ is the angle measured from the laser beam direction, k = ω/c0, β is the coefficient of thermal expansion, cp is the specific heat per unit mass, c0 is the speed of sound, and ρ0 is the density. Maximum radiation occurs at θ − π/2, in a direction perpendicular to the laser beam. [This work was supported by the U.S. Office of Naval Research.]
Investigation of Zeeman beats in a two-mode traveling-wave laser (1977)

A report is given of experimental and theoretical investigations of the sum of frequencies of the Zeeman beats of opposite waves in a two-mode He-Ne traveling-wave laser (?=1.15 ?) witn a circularly anisotropic resonator. It is shown that in a fairly wide range of detuning near the maximum of the gain curve the sum of the beat frequencies is proportional to the detuning. The coefficient of proportionality (magnetic sensitivity function) is considered as a function of the magnetic field applied to the active medium, excess of the gain over the losses, and pressure in the He?Ne mixture. The results can be used in the design of frequency-stabilized traveling-wave lasers.
Blind Source Separation Based on Fast-Convergence Algorithm Using ICA and Beamforming (2001)

IWAENC2001: International Workshop on Acoustic Echo and Noise Control, September 10-13, 2001, Darmstadt, Germany.
Late-breaking science abstracts (2008)

### A New Apolipoprotein Influencing Plasma Triglyceride Levels in Humans and Mice

Len Pennacchio, Lawrence Berkeley National Laboratory, Berkeley, CA; Michael Olivier, Medical College of Wisconsin, Milwaukee, WI; Jaroslav A Hubacek, Jonathan C Cohen, UT Southwestern Medical Center, Dallas, TX; David R Cox, Stanford Human Genome Center, Palo Alto, CA; Jamilla Fruchart, Pasteur Institute, Lille, France; Ronald M Krauss, Edward M Rubin, Lawrence Berkeley National Laboratory, Berkeley, CA 

The apolipoprotein gene cluster on human chromosome 11q23 (apoAI/CIII/AIV) represents a well-studied region that influences a variety of plasma lipid parameters and atherosclerosis susceptibility in humans. To facilitate the identification of evolutionarily conserved sequences with potential function near this cluster, we determined the sequence of ∼200 kbp of orthologous mouse DNA and compared the mouse and human sequences. The presence of a stretch of inter-species sequence conservation approximately 30 kbp proximal to the apoAI/CIII/AIV gene cluster, led us to an interval that upon further analysis was shown to encode a new member (apoAV) of the chromosome 11 apolipoprotein gene cluster. ApoAV transcripts were identified predominantly in liver tissue from mice and humans. To assess the function of apoAV, we generated mice over-expressing a human apoAV transgene as well as apoAV knockout mice. We observed dramatic but opposite effects on plasma triglyceride in these two groups of animals; a 3-fold decrease in plasma triglycerides in the apoAV transgenics and a 4-fold increase in the knockout mice. To explore the relationship between apoAV and lipid parameters in humans, several single nucleotide polymorphisms (SNPs) across the apoAV locus were identified and genotyped in two independent patient populations of normo-lipidemics. A common haplotype was found to be significantly associated with increased plasma triglycerides in the two large independent studies each employing different study designs. These findings in humans and mice illustrate the utility of comparative sequence analysis as a means to prioritize regions of the genome for further …
Exaggerated renal vascular reactivity to angiotensin and thromboxane in young genetically hypertensive rats (1990)

The objective of this study was to test the hypothesis that angiotensin II and thromboxane A2 (TxA2) contribute to the elevated renal vascular resistance observed during the development of genetic hypertension. In 6-wk-old anesthetized spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats, renal blood flow (electromagnetic flowmetry) and carotid arterial pressure were measured during bolus injections of different doses of angiotensin II and U46619 (stable receptor agonist of TxA2) into the renal artery before and during inhibition of prostaglandin synthesis by indomethacin. In all cases, arterial pressure remained unchanged at the pre-injection levels. Under control conditions, angiotensin II reduced renal blood flow in SHR almost twice as much as in WKY. This strain difference was abolished by inhibition of prostaglandin synthesis, suggesting that a deficiency in the action of endogenous vasodilator prostaglandins is responsible for the enhanced response to angiotensin II in SHR. Under control conditions, the TxA2-receptor agonist produced similar reductions of renal blood flow in SHR and WKY. However, after indomethacin, the agonist-induced vasoconstriction was twice as large in SHR as in WKY, suggesting that SHR kidneys have an increased vascular reactivity to TxA2, which is unmasked when indomethacin reduces elevated levels of endogenous TxA2. These findings indicate important strain differences between young SHR and WKY in the renal vascular response to angiotensin II and TxA2 that may contribute to the renal vasoconstriction observed during the development of genetic hypertension.
An n-gram hash and skip algorithm for finding large numbers of keywords in continuous text streams (1998)

A method of full-text scanning for matches in a large dictionary of keywords is described, suitable for Selective Dissemination of Information (SDI). The method is applicable to large dictionaries (say 104 to 105 entries), and to arbitrary byte streams for both patterns and data samples. The approach involves a sequence of tests, beginning with Boyer–Moore–Horspool skipping on digrams, followed by a succession of hash tests, and completed by trie searching, the combination of which is quite fast. Background information is provided, the algorithm and its implementation are described in detail, and experimental results are presented. In particular, tests suggest that the proposed method outperforms the algorithms of Aho–Corasick and Commentz–Walter when implementing large dictionaries. © 1998 John Wiley & Sons, Ltd.
The Effect of Interfacial Deformation on Electrodeposition Kinetics (2004)

Mullins-Sekerka linear stability analysis and the Barton and Bockris dendrite-propagation model are popular methods used to describe cathodic roughening and dendritic growth. These commonly cited theories employ kinetic relationships that differ in mathematical form, but both contain the effects of surface tension and local concentration deviations induced by surface roughening. Here, a kinetic model is developed which additionally includes mechanical forces such as elasticity, viscous drag, and pressure, showing their effect on exchange current densities and potentials at roughening interfaces. The proposed expression describes the current density in terms of applied overpotential at deformed interfaces with arbitrary three-dimensional interfacial geometry. Both the Mullins-Sekerka and the Barton-Bockris kinetics can be derived as special cases of the general expression, thereby validating the proposed model and elucidating the fundamental assumptions on which the two previous theories rely. © 2004 The Electrochemical Society. All rights reserved.
EFFICACY AND SAFETY OF LOW MOLECULAR WEIGHT HEPARIN IN RENAL TRANSPLANTATION1 (1998)

Prophylaxis with dalteparin is an effective and safe modality for the prevention of thrombosis in adult patients undergoing renal transplantation.
Thoracoscopical water jet lavage in coagulated hemothorax (2003)

We propose the use of a pulsatile high-speed irrigation device during video-assisted thoracoscopy for retained, in part coagulated hemothorax. Blood clots and membranes adhering to intrathoracic structures are easily removed by the water jet without damaging underlying structures. The efficient dilution of the sticky retained blood and the fragmented coagula enable their quick removal over a suction catheter.
Basic Evidence of the Molecular Dispersion of MnCeO<i><sub>x</sub></i>Catalysts Synthesized via a Novel “Redox-Precipitation” Route (2007)

A novel synthesis route driving redox-precipitation reactions among MnVII, CeIII, and MnII precursors in basic aqueous solution yields MnCeOx catalysts (Mnat/Ceat, 0.33−2.0) with a (quasi)molecular dispersion of the active phase and enhanced textural properties in comparison to the conventional coprecipitation method. The basic characteristics of the redox-precipitation process leading to a solid architecture missing a substantial “long-range” crystalline order are discussed. With an excellent reproducibility and irrespective of the Mnat/Ceat ratio, the redox-precipitation method also ensures unchanged textural, structural, and chemical properties of the MnCeOx catalysts. As a much improved dispersion of the active phase, the redox-precipitation route greatly promotes the redox behavior and the surface affinity toward gas-phase oxygen of the MnCeOx system.
Medulloblastoma: From Myth to Molecular (2017)

Current therapies for medulloblastoma were introduced primarily in the 1980s and consist of predominantly cytotoxic, nontargeted approaches. Mortality from medulloblastoma remains significant. In addition, many survivors suffer from severe treatment-related effects of radiation and cytotoxic chemotherapy. Further intensification of nonspecific therapy is unlikely to offer additional benefits, because survival rates have reached a plateau. Recent publications in medulloblastoma have revolved largely around the recognition that medulloblastoma per se does not exist, but rather, that there are a group of histologically similar but clinically and molecularly distinct entities that have been grouped under that rubric. Distinguishing the four molecular subgroups of medulloblastoma-wingless (WNT), sonic hedgehog (SHH), group 3, and group 4-in the daily treatment of patients, as well in the setting of clinical trials, is an important challenge in the near term for the pediatric neuro-oncology community. The preponderance of morbidity in treating patients with medulloblastoma is secondary to the treatment or prophylaxis of leptomeningeal metastases, and the cause of most deaths is leptomeningeal metastases. Recurrence of medulloblastoma is a nearly universally fatal event, with no significant salvage rate. The extent of spatial and temporal intratumoral heterogeneity as medulloblastoma metastasizes to leptomeninges and as it evolves in the face of radiation and cytotoxic chemotherapy is just beginning to be understood as a major barrier to therapeutic success. Pediatric neuro-oncology clinicians and scientists must now determine how best to incorporate rapid changes in our biologic understanding of medulloblastoma into the next generation of upfront clinical trials, with the goal of both improving survival for the highest-risk patients and improving quality of life for survivors.
Tagging-filter based blind MIMO equalization without signal permutation (2005)

In this paper, we propose a signal processing technique for blindly separating constant modulus sources in wireless communication systems. With the proposed technique, each source is pre-filtered using a unique allpass filter that we refer to here as a transmit tagging filter (TT-filter). At the receiver, an inverse model of the TT-filter is used to blindly equalize a multiple input multiple output (MIMO) channel and to retrieve desired signals without any permutation of the originally transmitted signals. This represents an important improvement over the conventional blind method, in which permutation of transmitted signals is known to accompany blind MIMO equalization. Computer simulations with constant modulus sources verify the effectiveness of the proposed system
Platelet activation during hemodialysis measured through exposure of p-selectin: analysis by flow cytometric and ultrastructural techniques. (1994)

P-selectin is a platelet protein in alpha-granules that is expressed on their membranes after platelet activation. Using a specific monoclonal antibody (RUU-2.17), we have studied platelet activation during hemodialysis with a cuprophan membrane in eight patients with uremia. Blood samples were obtained before hemodialysis from venipuncture (sample I), at the beginning of the hemodialysis from the arterial (sample II) and venous lines (sample III), and after 2 hours of hemodialysis from the venous line (sample IV). Exposure of P-selectin on platelet surface was studied by flow cytometry, and morphologic and immunocytochemical studies were performed. No differences in P-selectin expression were observed by single-labeling flow cytometry in samples I, II, and IV. However, a significant increase in fluorescence occurred in sample III (percentage of positive platelets [%PP], 18.0% +/- 6.1%) with respect to sample I (%PP, 6.9% +/- 2.0%; p < 0.01). An apparently decreased fluorescence was seen in sample IV (%PP, 8.8% +/- 3.9%) with respect to sample III. Double-labeling flow cytometry showed statistically significant differences between sample I (%PP, 7.1% +/- 2.6%) and sample III (%PP, 19.4% +/- 9.4%; p < 0.01) and IV (%PP, 19.0% +/- 10.1%; p < 0.01), but not between samples III and IV. The ultrastructural study revealed an increasing number of platelet morphologic signs of activation throughout the period of hemodialysis.(ABSTRACT TRUNCATED AT 250 WORDS)
David Held (2014)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsDavid Held is Master of University College, Durham and Professor of Politics and International Relations at Durham University. He is also the founding Director of the Global Policy Institute at Durham University, and Visiting Professor of Philosophy at LUISS University in Rome. A founder and Director of Polity Press, Held is also the founder of the prominent journal Global Policy. He holds a PhD in Political Science from the Massachusetts Institute of Technology and is author of more than 60 written or edited books and an extensive number of academic articles on democracy, democratization, globalization, global governance, and global policy. David Held is one of the most influential Anglo-American political theorist engaged in the project of 'globalizing political theory' beyond disciplinary boundaries and geographic borders while also grasping the theoretical significance of thickening forms of social interdependence nested under the keyword 'globalization'. His writings on global democratic theory and global governance issues have greatly contributed to the evolution of the transdisciplinary field of global studies. Among his most recent publications are Gridlock: Why Global Cooperation is Failing When We Need it Most (2013), co-authored with Thomas Hale and Kevin Young, Cosmopolitanism: Ideals and Realities (2010), and Climate Governance in the Developing World, edited with Eva-Maria Nag and Charlie Roger (2013).
Prevalence of PB1-F2 of influenza A viruses (2007)

PB1-F2 is a pro-apoptotic polypeptide of many influenza A virus (FLUAV) isolates encoded by an alternative ORF of segment 2. A comprehensive GenBank search was conducted to analyse its prevalence. This search yielded 2226 entries of 80 FLUAV subtypes. Of these sequences, 87 % encode a PB1-F2 polypeptide greater than 78 aa. However, classic swine influenza viruses and human H1N1 isolates collected since 1950 harbour a truncated PB1-F2 sequence. While PB1-F2 of human H1N1 viruses terminates after 57 aa, classic swine H1N1 sequences have in-frame stop codons after 11, 25 and 34 codons. Of the avian sequences, 96 % encode a full-length PB1-F2. One genetic lineage of segment 2 sequences which is avian-like and different from the classic swine FLUAV comprises PB1-F2 sequences of porcine FLUAVs isolated in Europe (H1N1, H1N2, H3N2). Of these PB1-F2 sequences, 42 % also exhibit stop codons after 11, 25 and 34 codons. These amino acid positions are highly conserved among all FLUAV isolates irrespective of their origin. Molecular genetic analyses reveal that PB1-F2 is under constraint of the PB1 gene. The PB1-F2 polypeptide of FLUAVs isolated from European pigs is expressed in host cells as demonstrated by immunohistochemistry. Using different PB1-F2 versions fused to an enhanced GFP, mitochondrial localization is demonstrated for those PB1-F2 polypeptides which are greater than 78 aa while a truncated version (57 aa) shows a diffuse cytoplasmic distribution. This indicates similar properties and function of porcine and human FLUAV PB1-F2.
Absence of an association between mannose-binding lectin polymorphism and rheumatoid arthritis (1998)

It has been proposed that mannose-binding lectin (MBL) interactions with agalactosyl forms of IgG immunoglobulins found in rheumatoid synovial fluid might lead to enhanced complement activation, an important mediator of the joint damage in rheumatoid arthritis (RA). In order to investigate this possible link between increased MBL-mediated activation of complement and perpetuation of rheumatoid synovitis, we have compared the frequency of an allelic form of MBL, known to be incapable of activating complement, in a group of hospital patients with severe RA and control subjects. No evidence was found to support an association between the presence of this MBL allele and protection from rheumatoid disease; genotype frequencies were similar in both groups. This suggests that complement activation via MBL-agalactosyl IgG complexes is unlikely to play a major role in the pathophysiology of RA.
Epigenetic transgenerational inheritance of somatic transcriptomes and epigenetic control regions (2012)

Combined observations demonstrate that all tissues derived from the epigenetically altered germ line develop transgenerational transcriptomes unique to the tissue, but common epigenetic control regions in the genome may coordinately regulate these tissue-specific transcriptomes. This systems biology approach provides insight into the molecular mechanisms involved in the epigenetic transgenerational inheritance of a variety of adult onset disease phenotypes.
Domain Wall Motion Device for Nonvolatile Memory and Logic — Size Dependence of Device Properties (2014)

Current-induced magnetic domain wall (DW)-motion device with a three- or four-terminal structure has considerable potential to trigger a profound transformation in memory and logic technologies. In this paper, we give an overview of DW-motion devices and describe their structure, operation method, and characteristics. Previous studies on the DW motion in nanowires with a Co/Ni multilayer are also reviewed. We also report on the experimental results regarding device properties, such as critical current, the time and energy required to displace the DW in the device, and retention properties with various device sizes down to 20 nm. The results reveal that writing properties are enhanced while sufficient retention properties are maintained as the device size is reduced, indicating that the DW-motion device has high scalability and compatibility with conventional semiconductor-based cells as well as ultralow power capability.