gebhart/patrepeval huggingface dataset:
Thickness correction of mammographic images by anisotropic filtering and interpolation of dense tissue (2005)

Without image processing, the dynamic range of display systems is too small to optimally display both the interior and the peripheral zone of a compressed breast. To overcome manual adjustment of contrast, we propose an algorithm for peripheral enhancement of digital or digitized mammograms. This is done by virtually adding homogeneous tissue at the peripheral zone, where the breast comes loose from the compression paddle. The gradual signal increase due to a smaller breast thickness near the breast edge is estimated by the solution of the anisotropic diffusion equation. The conductivity is set small in the direction perpendicular to the breast edge, and large in the parallel direction. By this, large conductivities (much blurring) can be applied, while undesirable artifacts that would be caused by isotropic filtering are minimized. This measure is not always enough to prevent some reduction of relevant contrast. Therefore, dense tissue along parallel curves to the breast edge is interpolated before smoothing the image. Anisotropic diffusion filtering and dense tissue interpolation are both new techniques to improve peripheral enhancement. Comparison with some other methods showed that our approach performs at least as good as other methods.
COMPUTERIZATION AND COMPETITIVENESS: NATIONAL INFORMATION INFRASTRUCTURE IN THE USA (1994)

nii & competition, 90294 COMPUTERIZATION AND COMPETITIVENESS: NATIONAL INFORMATION INFRASTRUCTURE IN THE USA Kenneth L. Kraemer Professor of Management and Information and Computer Science University of California, Irvine Irvine, CA 92717 kkraemer@uci.edu Working Paper #NII-054 Paper prepared for the workshop on NII and National Competitiveness October 18, 1994 Seoul, Korea August 30, 1994
Obituary (1967)

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Sources, Fate and Transport of Perfluorocarboxylates (2005)

This review describes the sources, fate, and transport of perfluorocarboxylates (PFCAs) in the environment, with a specific focus on perfluorooctanoate (PFO). The global historical industry-wide emissions of total PFCAs from direct (manufacture, use, consumer products) and indirect (PFCA impurities and/or precursors) sources were estimated to be 3200-7300 tonnes. It was estimated that the majority (approximately 80%) of PFCAs have been released to the environment from fluoropolymer manufacture and use. Although indirect sources were estimated to be much less importantthan direct sources, there were larger uncertainties associated with the calculations for indirect sources. The physical-chemical properties of PFO (negligible vapor pressure, high solubility in water, and moderate sorption to solids) suggested that PFO would accumulate in surface waters. Estimated mass inventories of PFO in various environmental compartments confirmed that surface waters, especially oceans, contain the majority of PFO. The only environmental sinks for PFO were identified to be sediment burial and transport to the deep oceans, implying a long environmental residence time. Transport pathways for PFCAs in the environment were reviewed, and it was concluded that, in addition to atmospheric transport/degradation of precursors, atmospheric and ocean water transport of the PFCAs themselves could significantly contribute to their long-range transport. It was estimated that 2-12 tonnes/ year of PFO are transported to the Artic by oceanic transport, which is greater than the amount estimated to result from atmospheric transport/degradation of precursors.
Lensless integrated optics spectrum analyzer (1982)

An electrooptic integrated optics spectrum analyzer is investigated in which an electrode array with a spatially varying period performs the functions of the collimation and transformation lenses and of the signal introduction. The device yields a weighted discrete Fourier transform (DFT) of the voltages on the electrodes. An implementation of the device would be fully compatible with planar photolithographic processes.
Effect of sodium glycyrrhetinate on chemical peritonitis in rats. (1997)

SG exerts its anti-inflammatory action by lowering permeability of capillaries in inflammatory site, inhibiting Neu emigration and PGE2 biosynthesis, and scavenging oxygen free radicals.
High Intensity Focused Ultrasound Technology, its Scope and Applications in Therapy and Drug Delivery (2014)

Ultrasonography is a safe, inexpensive and wide-spread diagnostic tool capable of producing real-time non-invasive images without significant biological effects. However, the propagation of higher energy, intensity and frequency ultrasound waves through living tissues can induce thermal, mechanical and chemical effects useful for a variety of therapeutic applications. With the recent development of clinically approved High Intensity Focused Ultrasound (HIFU) systems, therapeutic ultrasound is now a medical reality. Indeed, HIFU has been used for the thermal ablation of pathological lesions; localized, minimally invasive ultrasound-mediated drug delivery through the transient formation of pores on cell membranes; the temporary disruption of skin and the blood brain barrier; the ultrasound induced break-down of blood clots; and the targeted release of drugs using ultrasound and temperature sensitive drug carriers. This review seeks to engage the pharmaceutical research community by providing an overview on the biological effects of ultrasound as well as highlighting important therapeutic applications, current deficiencies and future directions.
Method of brazing aluminum to stainless steel for high-stress-fatigue applications (1968)

Brazing aluminum to titanium coated stainless steel to minimize formation of intermetallic compounds in joint
Texture measures for carpet wear assessment (1988)

Two standard approaches for texture analysis make use of numerical features of the second-order gray-level statistics, and on first-order statistics of gray-level differences, respectively. Feature sets of these types, all designed analogously, were used to analyze four sets of carpet samples exposed to different degrees of wear. It was found that some of the features extracted from the spatial gray-level-dependence matrix, neighboring gray-level-dependence matrix, gray-level difference method, and the gray-level run-length method allowed discrimination of degrees of wear in wool carpet. The methods developed could be of use in quality control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
PREPARATION AND POLYMERIZATION OF SOME PERFLUORODIENES, (1964)

Perfluorohexadiene was prepared by coupling 3-iodopentafluoropropene-1. Telomerization reactions were developed, which resulted in the preparation of precursors for perfluorohexadiene-1,5, perfluoroheptadiene-1,6, and perfluorooctadiene-1,7 from iodine monochloride, chlorotrifluoroethylene, and tetrafluoroethylene. Perfluorooctadiene, prepared from its precursor, polymerized readily under high pressure, and several polymer samples were obtained. These samples showed a high degree of cyclization as shown by infrared studies. (Author)
Design and Characterization of a Novel Hybrid Actuator Using Shape Memory Alloy and DC Micromotor for Minimally Invasive Surgery Applications (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The end-effectors in the state-of-the-art robotic tools for minimally invasive surgery (MIS) are actuated by actuator packs located outside the patient's body, with the power transmitted from the actuator pack to the end-effector by means of sliding link or tendon-driven mechanisms. This method of power transmission limits the number of degrees-of-freedom (DOFs) in these systems, as the design of a spherical wrist gets complicated. The design of the spherical wrists can be simplified, and the number of DOFs increased, if local actuation is used for the end-effector. However, there are no suitable actuation systems available in the literature. In this paper, a novel design idea for developing a millimeter-scale actuator is presented for locally actuating the end-effector (5-mm-diameter laparoscopic needle driver) for a robot performing MIS. This actuator is designed by combining a dc micromotor and a shape memory alloy actuator in series. The designed actuator is 5.14 mm in diameter (including casing) and 40 mm in length, and is used to actuate a 20-mm-long needle driver assembly, while generating a force of 24 N, resulting in a gripping force of 8 N. The total stroke length of the actuator is 1 mm, which results in a 45 <formula formulatype="inline"><tex>$^{\circ}$</tex></formula> opening of the needle driver jaw with a gap of 8 mm in between the jaws. </para>
The User Illusion: Cutting Consciousness Down to Size (1998)

As John Casti wrote, Finally, a book that really does explain consciousness. This groundbreaking work by Denmark's leading science writer draws on psychology, evolutionary biology, information theory, and other disciplines to argue its revolutionary point: that consciousness represents only an infinitesimal fraction of our ability to process information. Although we are unaware of it, our brains sift through and discard billions of pieces of data in order to allow us to understand the world around us. In fact, most of what we call thought is actually the unconscious discarding of information. What our consciousness rejects constitutes the most valuable part of ourselves, the Me that the I draws on for most of our actions -- fluent speech, riding a bicycle, anything involving expertise. No wonder that, in this age of information, so many of us feel empty and dissatisfied. As engaging as it is insightful, this important book encourages us to rely more on what our instincts and our senses tell us so that we can better appreciate the richness of human life.
X-ray phase contrast computed tomographic elementary experiments under incoherent conditions (2008)

Phase contrast imaging is one of up-to-date subjects in the X-ray imaging field. Grating-based phase contrast imaging method is the most promising method which can be applied to clinic diagnoses currently. A grating-based phase contrast computed tomography (CT) method under incoherent conditions is presented here. Moire deflectometry by use of projection of first absorption grating and the second absorption grating to measure differential phase shifts. The source grating is an option to be applied to improve the visibility of the projection of the first grating under the condition of the X-ray tube with big focal size. An elementary experimental phase contrast CT setup is built to validate this method. In conclusion, our method provides a feasible approach to practical application of phase contrast CT with conventional X-ray tubes.
A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA (2011)

A multifunctional reagent based on a coumarin scaffold was developed for derivatization of naive RNA. The alkylating agent N3BC [7-azido-4-(bromomethyl)coumarin], obtained by Pechmann condensation, is selective for uridine. N3BC and its RNA conjugates are pre-fluorophores which permits controlled modular and stepwise RNA derivatization. The success of RNA alkylation by N3BC can be monitored by photolysis of the azido moiety, which generates a coumarin fluorophore that can be excited with UV light of 320 nm. The azidocoumarin-modified RNA can be flexibly employed in structure-function studies. Versatile applications include direct use in photo-crosslinking studies to cognate proteins, as demonstrated with tRNA and RNA fragments from the MS2 phage and the HIV genome. Alternatively, the azide function can be used for further derivatization by click-chemistry. This allows e.g. the introduction of an additional fluorophore for excitation with visible light.
Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells. (2001)

We sought to characterize the interactions of flavopiridol with members of the ATP-binding cassette (ABC) transporter family. Cells overexpressing multidrug resistance-1 (MDR-1) and multidrug resistance-associated protein (MRP) did not exhibit appreciable flavopiridol resistance, whereas cell lines overexpressing the ABC half-transporter, ABCG2 (MXR/BCRP/ABCP1), were found to be resistant to flavopiridol. Flavopiridol at a concentration of 10 microM was able to prevent MRP-mediated calcein efflux, whereas Pgp-mediated transport of rhodamine 123 was unaffected at flavopiridol concentrations of up to 100 microM. To determine putative mechanisms of resistance to flavopiridol, we exposed the human breast cancer cell line MCF-7 to incrementally increasing concentrations of flavopiridol. The resulting resistant subline, MCF-7 FLV1000, is maintained in 1,000 nM flavopiridol and was found to be 24-fold resistant to flavopiridol, as well as highly cross-resistant to mitoxantrone (675-fold), topotecan (423-fold), and SN-38 (950-fold), the active metabolite of irinotecan. Because this cross-resistance pattern is consistent with that reported for ABCG2-overexpressing cells, cytotoxicity studies were repeated in the presence of 5 microM of the ABCG2 inhibitor fumitremorgin C (FTC), and sensitivity of MCF-7 FLV1000 cells to flavopiridol, mitoxantrone, SN-38, and topotecan was restored. Mitoxantrone efflux studies were performed, and high levels of FTC-reversible mitoxantrone efflux were found. Northern blot and PCR analysis revealed overexpression of the ABCG2 gene. Western blot confirmed overexpression of ABCG2; neither P-glycoprotein nor MRP overexpression was detected. These results suggest that ABCG2 plays a role in resistance to flavopiridol.
A segmental CRF approach to large vocabulary continuous speech recognition (2009)

This paper proposes a segmental conditional random field framework for large vocabulary continuous speech recognition. Fundamental to this approach is the use of acoustic detectors as the basic input, and the automatic construction of a versatile set of segment-level features. The detector streams operate at multiple time scales (frame, phone, multi-phone, syllable or word) and are combined at the word level in the CRF training and decoding processes. A key aspect of our approach is that features are defined at the word level, and are naturally geared to explain long span phenomena such as formant trajectories, duration, and syllable stress patterns. Generalization to unseen words is possible through the use of decomposable consistency features and our framework allows for the joint or separate discriminative training of the acoustic and language models. An initial evaluation of this framework with voice search data from the Bing Mobile (BM) application results in a 2% absolute improvement over an HMM baseline.
Inhibition of SNAP25 expression by HIV‐1 Tat involves the activity of mir‐128a (2008)

MicroRNAs (miRs) are short endogenous RNAs that regulate gene expression by incomplete pairing with messenger RNAs. An increasing number of studies show that mammalian microRNAs play fundamental roles in various aspects of cellular function including differentiation, proliferation, and cell death. Recent findings demonstrating the presence of microRNAs in mature neuronal dendrites suggest their possible involvement in controlling local protein translation and synaptic function. HIV-1 Encephalopathy (HIVE) is a manifestation of HIV-1 infection that often results in neuronal damage and dysfunction. While neurons are rarely, if ever, infected by HIV-1, they are exposed to cytotoxic viral and cellular factors including the HIV-1 transactivating factor Tat. In this study, we show that Tat deregulates expression levels of selected microRNAs, including the neuronal mir-128, in primary cortical neurons. We further show that mir-128a inhibits expression of the pre-synaptic protein SNAP25, whereas the anti-mir-128a partially restores Tat/mir-128a-induced downregulation of SNAP25 expression. Altogether, our data provide a novel mechanism by which HIV-Tat perturbs neuronal activity.
Millimeter-scale liquid metal droplet thermal switch (2018)

Devices capable of actively controlling heat flow have been desired by the thermal management community for decades. The need for thermal control has become particularly urgent with power densification resulting in devices with localized heat fluxes as high as 1 kW/cm2. Thermal switches, capable of modulating between high and low thermal conductances, enable the partitioning and active control of heat flow pathways. This paper reports a millimeter-scale thermal switch with a switching ratio &gt;70, at heat fluxes near 10 W/cm2. The device consists of a silicone channel filled with a reducing liquid or vapor and an immersed liquid metal Galinstan slug. Galinstan has a relatively high thermal conductivity (≈16.5 W/mK at room temperature), and its position can be manipulated within the fluid channel, using either hydrostatic pressure or electric fields. When Galinstan bridges the hot and cold reservoirs (the “ON” state), heat flows across the channel. When the hot and cold reservoirs are instead filled with the encapsulating liquid or vapor (the “OFF” state), the cross-channel heat flow significantly reduces due to the lower thermal conductivity of the solution (≈0.03–0.6 W/mK). We demonstrate switching ratios as high as 15.6 for liquid filled channels and 71.3 for vapor filled channels. This work provides a framework for the development of millimeter-scale thermal switches and diodes capable of spatial and temporal control of heat flows.
CLOUDS AND CHEMISTRY IN THE ATMOSPHERE OF EXTRASOLAR PLANET HR8799b (2011)

Using the integral field spectrograph OSIRIS, on the Keck II telescope, broad near-infrared H and K-band spectra of the young exoplanet HR8799b have been obtained. In addition, six new narrow-band photometric measurements have been taken across the H and K bands. These data are combined with previously published photometry for an analysis of the planet's atmospheric properties. Thick photospheric dust cloud opacity is invoked to explain the planet's red near-IR colors and relatively smooth near-IR spectrum. Strong water absorption is detected, indicating a Hydrogen-rich atmosphere. Only weak CH4 absorption is detected at K band, indicating efficient vertical mixing and a disequilibrium CO/CH4 ratio at photospheric depths. The H-band spectrum has a distinct triangular shape consistent with low surface gravity. New giant planet atmosphere models are compared to these data with best fitting bulk parameters, Teff = 1100K +- 100 and log(g) = 3.5 +-0.5 (for solar composition). Given the observed luminosity, log(Lobs/Lsun) ~ -5.1, these values correspond to a radius of 0.75 Rjup (+0.17, -0.12) and mass ~ 0.72 Mjup (+2.6,-0.6) -- strikingly inconsistent with interior/evolution models. Enhanced metallicity (up to ~ 10 times that of the Sun) along with thick clouds and non-equilibrium chemistry are likely required to reproduce the complete ensemble of spectroscopic and photometric data and the low effective temperatures (< 1000K) required by the evolution models.
Minimal qubit tomography (2004)

We present, and analyze thoroughly, a highly symmetric and efficient scheme for the determination of a single-qubit state, such as the polarization properties of photons emitted by a single-photon source. In our scheme there are only four measured probabilities, just enough for the determination of the three parameters that specify the qubit state, whereas the standard procedure would measure six probabilities.
Bradykinin stimulates afferent vagal C-fibers in intrapulmonary airways of dogs (1980)

Bradykinin is released in the lungs in asthma and pulmonary anaphylaxis. It has negligible direct bronchoconstrictor effects in humans or dogs, but inhaled as aerosol it causes cough and reflex bronchoconstriction in asthmatics and some normal subjects. The afferent nerves responsible for these reflex effects have not been identified. We recorded vagal impulses in anesthetized dogs to determine whether lung afferents were stimulated by bradykinin. C-fiber endings in the intrapulmonary airways accessible from the systemic circulation were stimulated by bradykinin injected into the left atrium (0.5-1.0 micrograms/kg) or bronchial artery (1.5 micrograms), activity increasing 15-fold on average. C-fiber endings accessible from the pulmonary circulation were relatively insensitive to bradykinin. Bradykinin caused a small increase in firing of some rapidly adapting (irritant) receptors, but the effect appeared to be secondary to vascular changes. Bradykinin had variable effects on slowly adapting stretch receptors, but did not stimulate them directly. Thus vagally mediated sensory or reflex effects initiated by bradykinin in the lung are probably due to stimulation of "bronchial" C-fibers.
Sensitivity Analysis in (Degenerate) Quadratic Programming (1996)

In this paper we deal with sensitivity analysis in convex quadratic programming, without making assumptions on nondegeneracy, strict convexity of the objective function, and the existence of a strictly complementary solution. We show that the optimal value as a function of a right--hand side element (or an element of the linear part of the objective) is piecewise quadratic, where the pieces can be characterized by maximal complementary solutions and tripartitions. Further, we investigate differentiability of this function. A new algorithm to compute the optimal value function is proposed. Finally, we discuss the advantages of this approach when applied to mean--variance portfolio models.
Review of motion analysis techniques (1989)

Motion analysis is an important component of computer vision, dealing with the measurement of motion information from a time varying image sequence. The analysis of dynamic image sequences finds a wide range of applications, including robot navigation, target tracking, traffic monitoring, motion of biological cells, cloud and weather systems tracking, image coding, etc. The paper reviews the various techniques used in motion analysis from image sequences. The approaches are classified according to the methodology in two main groups: methods based on the optical flow constraint equation, and matching. The advantages and disadvantages of both methodologies are also discussed.
Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype (2015)

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an inflammatory neuropathy, classically characterised by a slowly progressive onset and symmetrical, sensorimotor involvement. However, there are many phenotypic variants, suggesting that CIDP may not be a discrete disease entity but rather a spectrum of related conditions. While the abiding theory of CIDP pathogenesis is that cell-mediated and humoral mechanisms act together in an aberrant immune response to cause damage to peripheral nerves, the relative contributions of T cell and autoantibody responses remain largely undefined. In animal models of spontaneous inflammatory neuropathy, T cell responses to defined myelin antigens are responsible. In other human inflammatory neuropathies, there is evidence of antibody responses to Schwann cell, compact myelin or nodal antigens. In this review, the roles of the cellular and humoral immune systems in the pathogenesis of CIDP will be discussed. In time, it is anticipated that delineation of clinical phenotypes and the underlying disease mechanisms might help guide diagnostic and individualised treatment strategies for CIDP.