gebhart/patrepeval huggingface dataset:
Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone???related peptide receptor: a member of an ancient family of G protein???coupled receptors (1994)

The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor belongs to a newly discovered family of G protein-coupled receptors. Members of this family, which have been isolated from mammals, include the receptors for PTH/PTHrP, calcitonin, secretin, growth hormone-releasing hormone, vasoactive intestinal polypeptide (types 1 and 2), gastric-inhibitory polypeptide, glucagon-like peptide 1, glucagon, corticotropin-releasing factor, and the pituitary adenylate cyclase-activating peptide. Very recently, a receptor with remarkable homology to these mammalian receptors was isolated from the insect Manduca sexta, which indicates considerable conservation of these related proteins during evolution. Thus far the cognate ligands for these receptors are 27- to 46-amino-acid residues in length. Members of this novel receptor family are characterized by seven membrane-spanning domains and at least two conserved sites for N-linked glycosylation. Furthermore, 48-amino-acid residues, including eight extracellular cysteines, are identical in all receptors, and many other residues are highly conserved. The PTH/PTHrP receptor is expressed in a large variety of fetal and adult tissues, binds two ligands (PTH and PTHrP) with high affinity, and activates at least two second-messenger systems (adenylate cyclase and phospholipase C).
PCweek intranet and internet firewall strategies (1996)

What is a Firewall: Internetworking basics, FAQs, configurations , protocol issues, auditing, lures and traps, and administration why you need one: resources at risk, domains of trust, placement, multiple Firewalls on an Internetwork, weakest link problem What are the real threats: threats of open Internetworking, growth of Internet, Intranets, threat of open protocols, Internet and Intranet attacks simplified, risk management are all Firewalls the same? two major-types, packet filters, application-level gateways, additional types how a Firewall works: inside a Firewall, packet processing locations, packet filtering, session filtering, proxy applications, user authentication, auditing and alarms where to get Firewalls: building them from scratch, toolkits, commercial Firewalls, services important features of Firewalls: security requirements, basic access control, Firewall integrity, administration, supported services, speed, user authentication, auditing, alarms, special features the cost of Firewalls: cost of not having a Firewall, installation, administration why you need a security policy: security policies and Firewalls, specific issues, practical policy excerpts the on-going security process: countermeasures, cryptography, authentication, auditing and intrusion, detection, access control, using existing stuff. Appendices: terminology example security policy TCP/IP tutorial - Intro, message passing in the OSI model, TCP/IP basics, protocol and service suite, ports, numbers and types, IP addresses, IP packet format, TCP packet format, TCP sessions Firewall vendors decision-making matrix.
Synthesis and Evaluation of Eight- and Four-Membered Iminosugar Analogues as Inhibitors of Testicular Ceramide-Specific Glucosyltransferase, Testicular β-Glucosidase 2, and Other Glycosidases (2012)

Eight- and four-membered analogues of N-butyldeoxynojirimycin (NB-DNJ), a reversible male contraceptive in mice, were prepared and tested. A chiral pool approach was used for the synthesis of the target compounds. Key steps for the synthesis of the eight-membered analogues involve ring-closing metathesis and Sharpless asymmetric dihydroxylation and for the four-membered analogues Sharpless epoxidation, epoxide ring-opening (azide), and Mitsunobu reaction to form the four-membered ring. (3S,4R,5S,6R,7R)-1-Nonylazocane-3,4,5,6,7-pentaol (6) was moderately active against rat-derived ceramide-specific glucosyltransferase, and four of the other eight-membered analogues were weakly active against rat-derived β-glucosidase 2. Among the four-membered analogues, ((2R,3S,4S)-3-hydroxy-1-nonylazetidine-2,4-diyl)dimethanol (25) displayed selective inhibitory activity against mouse-derived ceramide-specific glucosyltransferase and was about half as potent as NB-DNJ against the rat-derived enzyme. ((2S,4S)-3-Hydroxy-1-nonylazetidine-2,4-diyl)dimethanol (27) was found to be a selective inhibitor of β-glucosidase 2, with potency similar to NB-DNJ. Additional glycosidase assays were performed to identify potential other therapeutic applications. The eight-membered iminosugars exhibited specificity for almond-derived β-glucosidase, and the 1-nonylazetidine 25 inhibited α-glucosidase (Saccharomyces cerevisiae) with an IC(50) of 600 nM and β-glucosidase (almond) with an IC(50) of 20 μM. Only N-nonyl derivatives were active, emphasizing the importance of a long lipophilic side chain for inhibitory activity of the analogues studied.
The effective use of Benford's Law to assist in detecting fraud in accounting data (2004)

Benford’s law has been promoted as providing the auditor with a tool that is simple and effective for the detection of fraud. The purpose of this paper is to assist auditors in the most effective use of digital analysis based on Benford’s law. The law is based on a peculiar observation that certain digits appear more frequently than others in data sets. For example, in certain data sets, it has been observed that more than 30% of numbers begin with the digit one. After discussing the background of the law and development of its use in auditing, we show where digital analysis based on Benford’s law can most effectively be used and where auditors should exercise caution. Specifically, we identify data sets which can be expected to follow Benford’s distribution, discuss the power of statistical tests, types of frauds that would be detected and not be detected by such analysis, the potential problems that arise when an account contains too few observations, as well as issues related to base rate of fraud. An actual example is provided demonstrating where Benford’s law proved successful in identifying fraud in a population of accounting data.
Metastatic Melanoma – A Review of Current and Future Treatment Options (2014)

Despite advances in treatment and surveillance, melanoma continues to claim approximately 9,000 lives in the US annually (SEER 2013). The National Comprehensive Cancer Network currently recommends ipilumumab, vemurafenib, dabrafenib, and high-dose IL-2 as first line agents for Stage IV melanoma. Little data exists to guide management of cutaneous and subcutaneous metastases despite the fact that they are relatively common. Existing options include intralesional Bacillus Calmette-Guérin, isolated limb perfusion/infusion, interferon-α, topical imiquimod, cryotherapy, radiation therapy, interferon therapy, and intratumoral interleukin-2 injections. Newly emerging treatments include the anti-programmed cell death 1 receptor agents (nivolumab and pembrolizumab), anti-programmed death-ligand 1 agents, and oncolytic vaccines (talimogene laherparepevec). Available treatments for select sites include adoptive T cell therapies and dendritic cell vaccines. In addition to reviewing the above agents and their mechanisms of action, this review will also focus on combination therapy as these strategies have shown promising results in clinical trials for metastatic melanoma treatment.
<i>Cdx1</i>and<i>Cdx2</i>have overlapping functions in anteroposterior patterning and posterior axis elongation (2002)

Mouse Cdx and Hox genes presumably evolved from genes on a common ancestor cluster involved in anteroposterior patterning. Drosophila caudal (cad) is involved in specifying the posterior end of the early embryo, and is essential for patterning tissues derived from the most caudal segment, the analia. Two of the three mouse Cdx paralogues, Cdx 1 and Cdx2, are expressed early in a Hox-like manner in the three germ layers. In the nascent paraxial mesoderm, both genes are expressed in cells contributing first to the most rostral, and then to progressively more caudal parts of the vertebral column. Later, expression regresses from the anterior sclerotomes, and is only maintained for Cdx1 in the dorsal part of the somites, and for both genes in the tail bud. Cdx1 null mutants show anterior homeosis of upper cervical and thoracic vertebrae. Cdx2-null embryos die before gastrulation, and Cdx2 heterozygotes display anterior transformations of lower cervical and thoracic vertebrae. We have analysed the genetic interactions between Cdx1 and Cdx2 in compound mutants. Combining mutant alleles for both genes gives rise to anterior homeotic transformations along a more extensive length of the vertebral column than do single mutations. The most severely affected Cdx1 null/Cdx2 heterozygous mice display a posterior shift of their cranio-cervical, cervico-thoracic, thoraco-lumbar, lumbo-sacral and sacro-caudal transitions. The effects of the mutations in Cdx1 and Cdx2 were co-operative in severity, and a more extensive posterior shift of the expression of three Hox genes was observed in double mutants. The alteration in Hox expression boundaries occurred early. We conclude that both Cdx genes cooperate at early stages in instructing the vertebral progenitors all along the axis, at least in part by setting the rostral expression boundaries of Hox genes. In addition, Cdx mutants transiently exhibit alterations in the extent of Hox expression domains in the spinal cord, reminding of the strong effects of overexpressing Cdx genes on Hox gene expression in the neurectoderm. Phenotypical alterations in the peripheral nervous system were observed at mid-gestation stages. Strikingly, the altered phenotype at caudal levels included a posterior truncation of the tail, mildly affecting Cdx2 heterozygotes, but more severely affecting Cdx1/Cdx2 double heterozygotes and Cdx1 null/Cdx2 heterozygotes. Mutations in Cdx1 and Cdx2 therefore also interfere with axis elongation in a cooperative way. The function of Cdx genes in morphogenetic processes during gastrulation and tail bud extension, and their relationship with the Hox genes are discussed in the light of available data in Amphioxus, C. elegans, Drosophila and mice.
High-grade Prostatic Intraepithelial Neoplasialike Ductal Adenocarcinoma of the Prostate: A Clinicopathologic Study of 28 Cases (2008)

Most of the prostatic ductal adenocarcinomas of the prostate are characterized by cribriform and/or papillary architecture lined by columnar pseudostratified malignant epithelium. We report 28 cases of ductal adenocarcinomas on needle biopsy and transurethral resection of prostate closely resembling high-grade prostatic intraepithelial neoplasia (HGPIN) composed of simple glands with flat, tufting, or micropapillary architecture. The mean age of the patients was 68 years (range, 50 to 91 y). Prostate specific antigen serum level at diagnosis ranged from 1.2 to 12.1 ng/mL. Treatment included radical prostatectomy (n=9), hormone therapy (n=7), radiotherapy (n=5), and cryotherapy (n=1). Three patients had recent biopsies without information on treatment and 3 patients were lost to follow-up after diagnosis. The number of cores involved by tumor in each case ranged from 1 to 18, with more than 1 core involved in 13 cases. Flat was the most common pattern (42%), followed by tufted (41%), and micropapillary (17%) (some with more than 1 pattern). Fourteen cases revealed segments of dilated gland on the edge of the biopsies, suggesting a large gland component. In radical prostatectomies, tumor was primarily composed of small (25%), medium (17%), or cystically dilated (58%) cancer glands, with all cases demonstrating a mixture of different gland sizes. Cytologically, tumors were characterized by tall columnar atypical cells, basally located nuclei, and amphophilic cytoplasm. The tumors lacked marked pleomorphism, necrosis, solid areas, cribriform formation, or true papillary fronds. Immunohistochemically, alpha-methyl acyl coenzyme-A racemase staining was seen in 93% of cases, with the majority showing strong and diffuse staining. No basal cells were present on p63 and/or high molecular weight cytokeratin staining. In the radical prostatectomy specimens, tumor volumes ranged from a small focus (less than 0.01 cm3) to 1.2 cm3. Concurrent conventional acinar Gleason score 6 adenocarcinomas were seen in 6 of the 9 radical prostatectomy cases, in all cases as separate nodules from the PIN-like ductal adenocarcinomas. Only one of the PIN-like ductal adenocarcinomas at radical prostatectomy had extraprostatic extension, which was focal. PIN-like ductal adenocarcinoma differs from HGPIN by the presence of cystically dilated glands, a greater predominance of flat architecture, and less frequently prominent nucleoli. Verification often requires the immunohistochemical documentation of the absence of basal cells in numerous atypical glands. Although usual ductal adenocarcinoma is considered comparable to Gleason score 8, PIN-like ductal adenocarcinoma was accompanied by Gleason score 6 acinar carcinoma and behaved similar to Gleason score 6 acinar cancer. Recognition of this entity is critical to differentiate it from both HGPIN and conventional ductal adenocarcinoma.
Taming the Devil: Techniques for Evaluating Anonymized Network Data (2008)

Anonymization plays a key role in enabling the public release of network datasets, and yet there are few, if any, techniques for evaluating the efficacy of network data anonymization techniques with respect to the privacy they afford. In fact, recent work suggests that many state-of-the-art anonymization techniques may leak more information than first thought. In this paper, we propose techniques for evaluating the anonymity of network data. Specifically, we simulate the behavior of an adversary whose goal is to deanonymize objects, such as hosts or web pages, within the network data. By doing so, we are able to quantify the anonymity of the data using information theoretic metrics, objectively compare the efficacy of anonymization techniques, and examine the impact of selective deanonymization on the anonymity of the data. Moreover, we provide several concrete applications of our approach on real network data in the hope of underscoring its usefulness to data publishers.
ANALYSIS OF PROFILE FUNCTIONS FOR GENERAL LINEAR (2007)

The stable approximate solution of ill-posed linear operator equations in Hilbert spaces requires regularization. Tight bounds for the noise-free part of the regularization error are constitutive for bounding the overall error. Norm bounds of the noise-free part which decrease to zero along with the regularization parameter are called profile functions and are the subject of our analysis. The interplay between properties of the regularization and certain smoothness properties of solution sets, which we shall describe in terms of sourcewise representations, is crucial for the decay of associated profile functions. On the one hand, we show that a given decay rate is possible only if the underlying true solution has appropriate smoothness. On the other hand, if smoothness fits the regularization, then decay rates are easily obtained. If smoothness does not fit, then we will measure this in terms of some distance function. Tight bounds for these allow us to obtain profile functions. Finally we study the most realistic case when smoothness is measured with respect to some operator which is related to the one governing the original equation only through a link condition. In many parts the analysis is done on geometric basis, extending classical concepts of linear regularization theory in Hilbert spaces. We emphasize intrinsic features of linear ill-posed problems which are frequently hidden in the classical analysis of such problems.
Cognitive Therapy: An Outline of Theory, Practice and Problems (1989)

ABSTRACT. An outline is presented of cognitive therapy beginning with the basic underlying theory followed by a description of the structure of therapy. A number of weak points within cognitive therapy are then identified, in particular, the failure to focus on the development of a working alliance, termination issues in therapy, and the concept of unconscious conflict. It is argued therefore that cognitive therapy has much that could be learned from the dynamic psychotherapies.
Selenium Speciation of Soil/Sediment Determined with Sequential Extractions and Hydride Generation Atomic Absorption Spectrophotometry (1996)

Understanding the speciation of the multioxidation states of selenium is vital to predicting the mineralization, mobilization, and toxicity of the trace element in natural systems. A sequential extraction scheme (SES) was developed for identification of Se oxidation states that first employed 0.1 M (pH 7.0) K2HPO4−KH2PO4 (P-buffer) to release soluble selenate (Se+VI) and selenide (Se-II) and ligand-exchangeable selenite (Se+IV). The second step involved oxidation of organic materials with 0.1 M K2S2O8 (90 °C) to release Se-II and Se+IV associated or occluded with organic matter. The final step used HNO3 (90 °C) to solubilize insoluble Se remaining in the sample. The solubilized Se compounds were speciated by a selective hydride generation atomic absorption spectrophotometry technique. Accuracy of the developed SES method (96−103% recovery) was verified by use of prepared Se compounds of known speciation, NIST standard reference materials, and existing seleniferous soils. The average precision (relative standard deviation) for the P-buffer extraction ranged from 5.5 to 7.7% (n = 12); the precision of the persulfate extraction ranged from 2.6 to 8.4% (n = 12); and the precision of the nitric acid extraction ranged from 2.8 to 7.4% (n = 12) for three soils extracted at four different time periods. The method was applied to analyze Se species in seleniferous plant, soil, and sediment samples.
Liver-Regenerative Transplantation: Regrow and Reset (2015)

Liver transplantation, either a partial liver from a living or deceased donor or a whole liver from a deceased donor, is the only curative therapy for severe end-stage liver disease. Only one-third of those on the liver transplant waiting list will be transplanted, and the demand for livers is projected to increase 23% in the next 20 years. Consequently, organ availability is an absolute constraint on the number of liver transplants that can be performed. Regenerative therapies aim to enhance liver tissue repair and regeneration by any means available (cell repopulation, tissue engineering, biomaterials, proteins, small molecules, and genes). Recent experimental work suggests that liver repopulation and engineered liver tissue are best suited to the task if an unlimited availability of functional induced pluripotent stem (iPS)-derived liver cells can be achieved. The derivation of iPS cells by reprogramming cell fate has opened up new lines of investigation, for instance, the generation of iPS-derived xenogeneic organs or the possibility of simply inducing the liver to reprogram its own hepatocyte function after injury. We reviewed current knowledge about liver repopulation, generation of engineered livers and reprogramming of liver function. We also discussed the numerous barriers that have to be overcome for clinical implementation.
An efficient architecture for nonhomogeneity detection in space-time adaptive processing airborne early warning radar (1997)

Emerging sensor technology has spawned renewed interest in the deployment of space-time adaptive processing (STAP) based airborne early warning (AEW) radar. Numerous theoretical studies and simulation analyses have clearly identified the potential for improved detection performance over classically designed AEW sensors, especially for weak target returns masked by sidelobe clutter and jamming. However, many of the underlying assumptions about the nature of the interference competing with and masking weak target returns are unrealistic. Most notable among these is the requirement for independent and identically distributed (i.i.d.) training data for covariance matrix estimation. The analysis of experimental data collected under the Rome Laboratory Multi-Channel Airborne Radar Measurements (MCARM) program clearly indicates that the nonhomogeneous nature of the clutter environment often results in severely degraded detection performance. The authors have developed a statistical signal processing technique designed to address this fundamental limitation to STAP, which is referred to in the literature as the nonhomogeneity detector (NHD). This algorithm is designed to be compatible with existing STAP techniques, and is used to screen training data for the excision of outliers prior to covariance matrix estimation. Published results indicate a significant improvement (in excess of several dB) in the detection performance for weak targets when NHD is applied in conjunction with STAP. The NHD performance and an efficient STAP architecture with embedded NHD are presented.
Techniques and Methods for Testing the Postural Function in Healthy and Pathological Subjects (2015)

The different techniques and methods employed as well as the different quantitative and qualitative variables measured in order to objectify postural control are often chosen without taking into account the population studied, the objective of the postural test, and the environmental conditions. For these reasons, the aim of this review was to present and justify the different testing techniques and methods with their different quantitative and qualitative variables to make it possible to precisely evaluate each sensory, central, and motor component of the postural function according to the experiment protocol under consideration. The main practical and technological methods and techniques used in evaluating postural control were explained and justified according to the experimental protocol defined. The main postural conditions (postural stance, visual condition, balance condition, and test duration) were also analyzed. Moreover, the mechanistic exploration of the postural function often requires implementing disturbing postural conditions by using motor disturbance (mechanical disturbance), sensory stimulation (sensory manipulation), and/or cognitive disturbance (cognitive task associated with maintaining postural balance) protocols. Each type of disturbance was tackled in order to facilitate understanding of subtle postural control mechanisms and the means to explore them.
Data/knowledge packets as a means of supporting semantic heterogeneity in multidatabase systems (1991)

Semantic heterogeneiry in heterogeneous autonomous databases poses problems in instance matches, units conversion (value interpretation), contextual and structural mismatches, etc. In this work we examine some of the research issues in semantic heterogeniety and propose a novel architecture for resolving such problems. The approach involves the use of Artifical Intelligence tools and techniques to construct “domain models,” that is data and knowledge representations of the constituent databases and an overall domain model of the semantic interactions among the databases. These domain models are represented as knowledge sources (KSs) in a blackboard architecture. This architecture lends itself to an opportunistic approach to query processing and goal-directed problem solving. We introduce the notion of Data/Knowledge Packets as a means of supporting both operational and structural semantic heterogeneity.