gebhart/patrepeval huggingface dataset:
Automatic Coordinated Control of Pump Rates and Choke Valve for Compensating Pressure Fluctuations during Surge and Swab Operations (2007)

Abstract In this paper we present new methods for coordinated control of pump rates and choke valve for compensating pressure fluctuations during surge and swab operations. In hydrocarbon well drilling, automatic control of the choke valve improves the control of the bottom-hole pressure. This has made it possible to drill wells where it previously was not possible to reach total depth, due to narrow pressure margins in the reservoir. This concept is developed further in this paper, to also include automatic control of pump rates, coordinated with the choke valve control. In configurations where the choke valve is fitted with a flow rate controllable annulus back-pressure pump, the situation calls for structured methods for automatic and coordinated control of the main mud pump, the back-pressure pump and the annulus return choke valve. In this paper, well known methods for multivariable control are applied to the drilling process. These methods are based on identification of coupling and interaction between system input (controllable variables), e.g. pump rates and choke valve settings, and output (measured or estimated variables), e.g. pressure at given depths. It is shown how the well pressure profile can be kept within tight margins, subject to disturbances such as drillstring movement in surge and swab operations. Automatic coordinated control is shown through numerical simulations on a detailed, space-discretized well model. Comparisons are made with the case of complete manual control and the intermediate case where only the annulus return choke line pump is automated, using a simple linear controller. The results with automatic coordinated control of pump rates and choke valve are very promising - the performance of such a solution, measured by variance in pressure fluctuations, is improved - compared to both the case of manual control and the case of only automated choke line pump control.
Bending Behavior of Carbon/Epoxy Composite IsoBeam Structures (2015)

This research demonstrated the fabrication, flexural testing, and analysis of nominally 5 ft (1.5 m) 6-bay and 10 ft (3 m) 12-bay carbon/epoxy IsoBeam™ structures. The rectangular cross-section was 5 in (12.7 cm) wide by 10 in (25.4 cm) high. The IsoBeam structure is a composite lattice structure that is a geometric derivative of the IsoTruss® structure. Modifying the geometry to yield a rectangular cross-section provides additional applications for these beams as structural elements in buildings, aircraft, vehicles, and other structures. The diameters of the constituent members of the IsoBeam, namely the longitudinal and diagonal members, were sized such that the IsoBeam could hold the design load of a 10K1 steel joist 550 plf (818.5 kg/m). Three IsoBeam structures were manufactured: two 5 ft (1.5 m) long and one 10 ft (3 m) long. The IsoBeam structures were manufactured with carbon/epoxy composite tows comprised of T700SC-12K-50C carbon fibers and UF3369-100 pre-impregnated (pre-preg) epoxy resin. The pre-preg tows were positioned on a modified pin-mandrel under tension using a combination of hand and machine filament winding in an interwoven pattern to create the complex geometry of the IsoBeam structure. Each member was circumferentially wrapped with 1 in (2.5 cm) wide strips of Dunstone Hi-Shrink Tape (polyester) to consolidate the tows during the manufacturer’s recommended curing process. Microscopic measurements after testing established that these careful manufacturing techniques produced high-quality specimens with an average void ratio of 0.72% and an average fiber volume fraction of 69.5%. The average compression stiffness and strength were 18.7 ksi (129 GPa) and 115.1 ksi (793 MPa), respectively.Each IsoBeam was loaded in four-point bending to failure, with other tests performed in the linear-elastic range to study load path behavior of the IsoBeam. Strain, deflection, and load data were collected to provide a detailed understanding of the behavior of individual members under load and their corresponding stresses. The 6-bay IsoBeam structures experienced failure at 8055 lbs (35.8 kN) and 11224 lbs (49.9 kN), in compression initiated by buckling. The longer 12-bay IsoBeam structure failed in a similar manner at 8035 lbs (35.7 kN) but also exhibited delamination, due to insufficient interweaving.Experimental results were compared to the predicted strength of the IsoBeam based on a linear finite element model (created using SAP 2000) and hand calculations. Validation of the design through the comparison of experimental and predicted values gave insight on design techniques and overall understanding of the performance of the IsoBeam in bending, with excellent correlation in the linear range. The assumption that longitunals are primarily responsible for bending strength and diagonals primarily carry shear was validated, indicating a strong correlation between manufacturing quality and performance of IsoBeam structures.
Hardware implementation of a general multi-way jump mechanism (1990)

A VLIW architecture capable of testing multiple conditions in one cycle must support effective multiway (conditional) jumps. In this paper, a hardware-implemented, fast, and space-efficient multi-way jump mechanism is developed that speeds up the execution of multiple conditional jumps and reduces wasted storage. A cluster of multiple conditional jumps packed in an instruction can form an arbitrary rooted DAG (directed acyclic graph), where each node corresponds to a condition. The authors scheme provides a hardware device called an M-unit, which can combinationally produce the next target address using an encoded description of the DAG and the actual test bits. A technique to reduce the number of different configurations is introduced, along with a memory packing scheme that minimizes wasted memory. >
Pulse Generator and Flip-Flops (1972)

A simple pulse generator can be constructed using IC gates. Such a pulse generator is described and its use to construct edge-triggered flip-flops is demonstrated. A flip-flop for use in a phase comparator is described. Desirable and undesirable characteristics for this application are discussed and examples of R-S and J-K flip-flops given.
Predicting subscriber dissatisfaction and improving retention in the wireless telecommunications industry (2000)

Competition in the wireless telecommunications industry is fierce. To maintain profitability, wireless carriers must control churn, which is the loss of subscribers who switch from one carrier to another.We explore techniques from statistical machine learning to predict churn and, based on these predictions, to determine what incentives should be offered to subscribers to improve retention and maximize profitability to the carrier. The techniques include logit regression, decision trees, neural networks, and boosting. Our experiments are based on a database of nearly 47,000 U.S. domestic subscribers and includes information about their usage, billing, credit, application, and complaint history. Our experiments show that under a wide variety of assumptions concerning the cost of intervention and the retention rate resulting from intervention, using predictive techniques to identify potential churners and offering incentives can yield significant savings to a carrier. We also show the importance of a data representation crafted by domain experts. Finally, we report on a real-world test of the techniques that validate our simulation experiments.
<scp>DNA</scp>demethylation and invasive cancer: implications for therapeutics (2014)

One of the hallmarks of cancer is aberrant DNA methylation, which is associated with abnormal gene expression. Both hypermethylation and silencing of tumour suppressor genes as well as hypomethylation and activation of prometastatic genes are characteristic of cancer cells. As DNA methylation is reversible, DNA methylation inhibitors were tested as anticancer drugs with the idea that such agents would demethylate and reactivate tumour suppressor genes. Two cytosine analogues, 5-azacytidine (Vidaza) and 5-aza-2'-deoxycytidine, were approved by the Food and Drug Administration as antitumour agents in 2004 and 2006 respectively. However, these agents might cause activation of a panel of prometastatic genes in addition to activating tumour suppressor genes, which might lead to increased metastasis. This poses the challenge of how to target tumour suppressor genes and block cancer growth with DNA-demethylating drugs while avoiding the activation of prometastatic genes and precluding the morbidity of cancer metastasis. This paper reviews current progress in using DNA methylation inhibitors in cancer therapy and the potential promise and challenges ahead.
Nitric acid oxidation of Si to form ultrathin silicon dioxide layers with a low leakage current density (2003)

Ultrathin silicon dioxide (SiO2) layers with excellent electrical characteristics can be formed using the nitric acid oxidation of Si (NAOS) method, i.e., by immersion of Si in nitric acid (HNO3) solutions. The SiO2 layer formed with 61 wt % HNO3 at its boiling temperature of 113 °C has a 1.3 nm thickness with a considerably high density leakage current. When the SiO2 layer is formed in 68 wt % HNO3 (i.e., azeotropic mixture with water), on the other hand, the leakage current density (e.g., 1.5 A/cm2 at the forward gate bias, VG, of 1 V) becomes as low as that of thermally grown SiO2 layers, in spite of the nearly identical SiO2 thickness of 1.4 nm. Due to the relatively low leakage current density of the NAOS oxide layer, capacitance–voltage (C–V) curves can be measured in spite of the ultrathin oxide thickness. However, a hump is present in the C–V curve, indicating the presence of high-density interface states. Fourier transformed infrared absorption measurements show that the atomic density of the SiO2 layers increases by 7% with an increase in the HNO3 concentration from 61 to 68 wt %. Measurements of valence band spectra clarify that this concentration increase causes the enhancement of the valence band discontinuity at the Si/SiO2 interface from 4.1 to 4.3 eV. When postmetallization annealing (PMA) treatment is performed at 400 °C in hydrogen on 〈aluminum (Al)/chemical SiO2/Si(100)〉 metal–oxide–semiconductor diodes, the leakage current density markedly increases, and this increase is attributed to a reaction between the Al electrode and the chemical SiO2 layer, resulting in a decrease in the SiO2 thickness. With PMA at 200 °C in hydrogen, on the other hand, the SiO2 thickness decreases only slightly to 1.3 nm. In this case, the leakage current density greatly decreases (e.g., 0.4 A/cm2 at VG=1 V and 5×10−3 A/cm2 at VG=−1 V), and consequently it becomes 1/3–1/10 of those for thermally grown SiO2 layers with the same thickness. The hump in the C–V curves disappears after PMA at 200 °C, indicating the elimination of interface states, and the interface state passivation is attributed to one of the reasons for the decrease in the leakage current density. Measurements of the valence band spectra show that another reason for the decrease in the leakage current density by PMA are an increase in the band discontinuity at the Si/SiO2 interface, and the elimination of SiO2 gap states.
40 Gbit/s operation of laser-integrated electroabsorption modulator using identical InGaAlAs quantum wells (2005)

We demonstrate 40 Gbit/s operation of an InP-based 1.3 mum laser-integrated electroabsorption modulator using an identical InGaAlAs quantum well stack in both device sections. Characteristic data are 22 mA threshold current and 35 dB side-mode suppression ratio
Channel estimation for spatial modulation orthogonal frequency division multiplexing systems (2015)

A combination of spatial modulation and orthogonal frequency division multiplexing (SM-OFDM) has been recently proposed for multicarrier systems while assuming the perfect channel state information (P-CSI) available at the receiver. But, in practical scenarios, the estimation of CSI is crucial in order to detect the transmitted data coherently. In this work <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> , a new frame structure and pilot symbol aided channel estimation (PSA-CE) technique with a piecewise linear interpolation is proposed for the SM-OFDM systems operating in the presence of frequency selective channel. Bit error rate (BER) performance of the proposed channel estimation technique is then investigated with different channel models such as Typical Urban (TU) and Rural Urban (RU) for 4-quadrature amplitude modulation (QAM). In particular, it is shown that the performance with estimated channel came close to that with known channel within 2.3 dB in SNR for BER = 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−4</sup> for TU channels.
Renin overexpression leads to increased titin-based stiffness contributing to diastolic dysfunction in hypertensive mRen2 rats (2016)

Hypertension (HTN) is a major risk factor for heart failure. We investigated the influence of HTN on cardiac contraction and relaxation in transgenic renin overexpressing rats (carrying mouse Ren-2 renin gene, mRen2, n = 6). Blood pressure (BP) was measured. Cardiac contractility was characterized by echocardiography, cellular force measurements, and biochemical assays were applied to reveal molecular mechanisms. Sprague-Dawley (SD) rats (n = 6) were used as controls. Transgenic rats had higher circulating renin activity and lower cardiac angiotensin-converting enzyme two levels. Systolic BP was elevated in mRen2 rats (235.11 ± 5.32 vs. 127.03 ± 7.56 mmHg in SD, P < 0.05), resulting in increased left ventricular (LV) weight/body weight ratio (4.05 ± 0.09 vs. 2.77 ± 0.08 mg/g in SD, P < 0.05). Transgenic renin expression had no effect on the systolic parameters, such as LV ejection fraction, cardiomyocyte Ca(2+)-activated force, and Ca(2+) sensitivity of force production. In contrast, diastolic dysfunction was observed in mRen2 compared with SD rats: early and late LV diastolic filling ratio (E/A) was lower (1.14 ± 0.04 vs. 1.87 ± 0.08, P < 0.05), LV isovolumetric relaxation time was longer (43.85 ± 0.89 vs. 28.55 ± 1.33 ms, P < 0.05), cardiomyocyte passive tension was higher (1.74 ± 0.06 vs. 1.28 ± 0.18 kN/m(2), P < 0.05), and lung weight/body weight ratio was increased (6.47 ± 0.24 vs. 5.78 ± 0.19 mg/g, P < 0.05), as was left atrial weight/body weight ratio (0.21 ± 0.03 vs. 0.14 ± 0.03 mg/g, P < 0.05). Hyperphosphorylation of titin at Ser-12742 within the PEVK domain and a twofold overexpression of protein kinase C-α in mRen2 rats were detected. Our data suggest a link between the activation of renin-angiotensin-aldosterone system and increased titin-based stiffness through phosphorylation of titin's PEVK element, contributing to diastolic dysfunction.
Data Acquisition Aspects of Super-PETT (1982)

Incorporation of differential time-of-flight (TOF) information in positron emission tomography offers significant performance improvement at the cost of increasing the quantity of data to be processed. A tomographic unit utilizing TOF data, called Super-PETT, is currently nearing the final stage of construction. Design and implementation aspects of the data acquisition system are described with an emphasis on instrument operation in an on-line preprocessing mode.
Taxicab tipping and sunlight (2017)

Does the level of sunlight affect the tipping percentage in taxicab rides in New York City? We examined this question using data on 13.82 million cab rides from January to October in 2009 in New York City combined with data on hourly levels of solar radiation. We found a small but statistically significant positive relationship between sunlight and tipping, with an estimated tipping increase of 0.5 to 0.7 percentage points when transitioning from a dark sky to full sunshine. The findings are robust to two-way clustering of standard errors based on hour-of-the-day and day-of-the-year and controlling for day-of-the-year, month-of-the-year, cab driver fixed effects, weather conditions, and ride characteristics. The NYC cab ride context is suitable for testing the association between sunlight and tipping due to the largely random assignment of riders to drivers, direct exposure to sunlight, and low confounding from variation in service experiences.
A snake for model-based segmentation (2002)

Despite the promising results of numerous applications, the hitherto proposed snake techniques share some common problems: snake attraction by spurious edge points, snake degeneration (shrinking and flattening), convergence and stability of the deformation process, snake initialization and local determination of the parameters of elasticity. We argue here that these problems can be solved only when all the snake aspects are considered. The snakes proposed here implement a new potential field and external force in order to provide a deformation convergence, attraction by both near and far edges as well as snake behaviour selective according to the edge orientation. Furthermore, we conclude that in the case of model-based segmentation, the internal force should include structural information about the expected snake shape. Experiments using this kind of snakes for segmenting bones in complex hand radiographs show a significant improvement.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Electroporation of mammalian cells by nanosecond electric field oscillations and its inhibition by the electric field reversal (2015)

The present study compared electroporation efficiency of bipolar and unipolar nanosecond electric field oscillations (NEFO). Bipolar NEFO was a damped sine wave with 140 ns first phase duration at 50% height; the peak amplitude of phases 2-4 decreased to 35%, 12%, and 7% of the first phase. This waveform was rectified to produce unipolar NEFO by cutting off phases 2 and 4. Membrane permeabilization was quantified in CHO and GH3 cells by uptake of a membrane integrity marker dye YO-PRO-1 (YP) and by the membrane conductance increase measured by patch clamp. For treatments with 1-20 unipolar NEFO, at 9.6-24 kV/cm, 10 Hz, the rate and amount of YP uptake were consistently 2-3-fold higher than after bipolar NEFO treatments, despite delivering less energy. However, the threshold amplitude was about 7 kV/cm for both NEFO waveforms. A single 14.4 kV/cm unipolar NEFO caused a 1.5-2 times greater increase in membrane conductance (p<0.05) than bipolar NEFO, along with a longer and less frequent recovery. The lower efficiency of bipolar NEFO was preserved in Ca2+-free conditions and thus cannot be explained by the reversal of electrophoretic flows of Ca2+. Instead, the data indicate that the electric field polarity reversals reduced the pore yield.
Hydrocarboxylation of Allenes with CO<sub>2</sub> Catalyzed by Silyl Pincer-Type Palladium Complex (2008)

Tridentate PSiP pincer-type palladium complex-catalyzed hydrocarboxylation of allenes under carbon dioxide to give synthetically useful beta,gamma-unsaturated carboxylic acids was developed. This novel CO2-fixation reaction is thought to proceed through the catalytic generation of sigma-allyl palladium species via hydropalladation of allenes, followed by its regioselective nucleophilic addition to CO2 in the presence of an appropriate reducing agent. The reaction is successfully applied to various allenes bearing functional groups such as ester, carbamate, ketone, and alkene, showing high synthetic utility of this protocol.
Novel antisense therapeutics delivery systems: In vitro and in vivo studies of liposomes targeted with anti-CD20 antibody (2015)

Antisense gene therapy using molecules such as antisense oligodeoxynucleotides, siRNA or miRNA is a very promising strategy for the treatment of neoplastic diseases. It can be combined with other treatment strategies to enhance therapeutic effect. In acute leukemias, overexpression of the antiapoptotic gene BCL2 is observed in more than 70% of cases. Therefore, reduction of the Bcl-2 protein level could, in itself, prevent the development of cancer or could possibly help sensitize cancer cells to apoptosis inducers. The main objective of our work is to develop therapeutic liposome formulations characterized by high transfection efficiency, stability in the presence of serum, as well as specificity and toxicity for target (leukemic) cells. Each of our liposomal formulations consists of a core composed of antisense oligonucleotides complexed by either cationic lipid, DOTAP, or a synthetic polycation, polyethyleneimine, encapsulated within liposomes modified with polyethylenoglycol. In addition, the liposomal shells are enriched with covalently-bound antibodies recognizing a well characterized bio-marker, CD20, exposed on the surface of leukemia cells. The resulting immunoliposomes selectively and effectively reduced the expression of BCL2 in target cells. Model animal experiments carried out on mice-engrafted tumors expressing the specific marker showed high efficiency of the liposome formulations against specific tumor development. In conclusion, we show that lipid formulations based on a polyplex or lipoplex backbone additionally equipped with antibodies are promising non-viral vectors for specific oligonucleotide transfer into human tumor cells.
La doble vía europea en protección de datos (2012)

Si algo destaca en el estudio de la Proteccion de datos es la juventud que caracteriza los cuerpos normativos que se analizan y la constante evolucion tecnologica que los somete y condiciona. De hecho, la Directiva Europea 46/1995, primer intento serio de llegar a un acuerdo armonizador en la materia se ha visto totalmente superada tras sus dieciseis anos de vigencia. Esta ola de cambio se ha aprovechado, no solo para adaptar sus contenidos a las innovaciones tecnologicas que en este periodo se han producido, sino tambien para alcanzar un estadio mayor de armonizacion interestatal. A su vez, tras la nueva situacion competencial introducida por el Tratado de Lisboa, y la desaparicion del Tercer Pilar, la Union Europea se atreve con la regulacion especifica del regimen de proteccion de datos en ficheros policiales. Algo que hasta el momento rozaba los limites de sus competencias.
Influence of the ion-pair-formation on the pharmacokinetic properties of drugs. Part 5: Influence of ion-pair-formation on elimination of bretylium and hexylsalicylic acid in rats. (1989)

Following i.v. administration of the hydrophilic drug bretylium (1) and the lipophilic hexylsalicylic acid (2) in rats the plasma levels of 2 were increased due to an increased intestinal reabsorption of 2. Under these conditions the biliary eliminated amount of 2 was 8 times higher than that following the administration of 2 alone. The eneteroheptic circulation of 2 was found to be interrupted following i.v. administration of 1 and 2 and additional oral administration of an anionic exchanger. Then the plasma levels of 2 were not influenced by 1. On other hand the plasma levels of 2 appear to be too low in order to influence those of 1.
Raf-1 Without MEK? (2001)

The Ras-Raf-MEK [(mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) kinase]-MAPK signaling pathway controls the activation of many cellular functions. Recent reports of Raf-1-deficient mice have indicated that MEK may not be an important downstream substrate for Raf-1 and that, in fact, Raf-1 is important for blocking apoptosis rather than for cell proliferation. Murakami and Morrison examine these recent findings and discuss their implications, as well as other possible conclusions that may be drawn from the published data.