gebhart/patrepeval huggingface dataset:
Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1 (2012)

Doxorubicin is used extensively for chemotherapy of diverse types of cancer, yet the mechanism through which it inhibits proliferation of cancer cells remains unclear. Here we report that doxorubicin stimulates de novo synthesis of ceramide, which in turn activates CREB3L1, a transcription factor synthesized as a membrane-bound precursor. Doxorubicin stimulates proteolytic cleavage of CREB3L1 by Site-1 Protease and Site-2 Protease, allowing the NH(2)-terminal domain of CREB3L1 to enter the nucleus where it activates transcription of genes encoding inhibitors of the cell cycle, including p21. Knockdown of CREB3L1 mRNA in human hepatoma Huh7 cells and immortalized human fibroblast SV589 cells conferred increased resistance to doxorubicin, whereas overexpression of CREB3L1 in human breast cancer MCF-7 cells markedly enhanced the sensitivity of these cells to doxorubicin. These results suggest that measurement of CREB3L1 expression may be a useful biomarker in identifying cancer cells sensitive to doxorubicin.DOI:http://dx.doi.org/10.7554/eLife.00090.001.
Substrate Dependent Self-Organization of Mesoporous Cobalt Oxide Nanowires with Remarkable Pseudocapacitance (2012)

A scheme of current collector dependent self-organization of mesoporous cobalt oxide nanowires has been used to create unique supercapacitor electrodes, with each nanowire making direct contact with the current collector. The fabricated electrodes offer the desired properties of macroporosity to allow facile electrolyte flow, thereby reducing device resistance and nanoporosity with large surface area to allow faster reaction kinetics. Co(3)O(4) nanowires grown on carbon fiber paper collectors self-organize into a brush-like morphology with the nanowires completely surrounding the carbon microfiber cores. In comparison, Co(3)O(4) nanowires grown on planar graphitized carbon paper collectors self-organize into a flower-like morphology. In three electrode configuration, brush-like and flower-like morphologies exhibited specific capacitance values of 1525 and 1199 F/g, respectively, at a constant current density of 1 A/g. In two electrode configuration, the brush-like nanowire morphology resulted in a superior supercapacitor performance with high specific capacitances of 911 F/g at 0.25 A/g and 784 F/g at 40 A/g. In comparison, the flower-like morphology exhibited lower specific capacitance values of 620 F/g at 0.25 A/g and 423 F/g at 40 A/g. The Co(3)O(4) nanowires with brush-like morphology exhibited high values of specific power (71 kW/kg) and specific energy (81 Wh/kg). Maximum energy and power densities calculated for Co(3)O(4) nanowires with flower-like morphology were 55 Wh/kg and 37 kW/kg respectively. Both electrode designs exhibited excellent cycling stability by retaining ∼91-94% of their maximum capacitance after 5000 cycles of continuous charge-discharge.
Genomic Organization and Sequence Analysis of Rabbit Muscle Phosphofructokinase Gene. (1986)

A rabbit genomic clone containing the muscle phosphofructokinase (PFK) gene of approximately 17 kilobase pairs encoding 779 amino acids was isolated and sequenced. This gene contains 22 exons, ranging from 45 to 190 base pairs, and is split by 21 introns of 73-3500 base pairs. Eighty six percent of this gene is occupied by introns. An additional incomplete intron is found in the 5' flanking region, while an Alu-like sequence is identified in the 3' flanking region. The amino acid sequence translated from the coding sequence of this gene reveals 29 residues (amino acid numbers 479-507) which complete a previously unidentified gap Poorman, R. A. et al., Nature, 309, 467 (1984) and 4 positions of discrepancy; Ser (--->) Arg (268), Leu (--->) Pro (442), Ile (--->) Ser (558), and the insertion of an additional Arg at position 565. Twelve exons encoding the N-half of the protein are scattered over 13 kbp and the other ten exons encoding the C-half are clustered in a length of 4 kbp. Most introns in this gene occupy positions between or at the ends of the secondary structural elements, but they are not located at identical positions in the two protein-coding halves of the gene. When these exons are identified with their encoded functional subdomains, the exon arrangement shows a duplication pattern between the two halves of the gene. These data support, at the gene level, the hypothesis that mammalian PFK evolved from a prokaryotic progenitor by gene duplication and divergence.
LD Pumped Cr~(4+), Nd~(3+)∶YAG with Self-Q-switched Laser Output of 1.4 W (2001)

By using LD as a pumping source, the self-Q-switched laser of Cr,Nd∶YAG crystal is demonstrated. The output Q-switched traces are very stable. The threshold pumping power is 3.5 W and pulse duration is 50 ns. The slope efficiency is as high as 20%. When the input power is 10.8 W, 1.46 W self-Q-switched laser at 1064 nm is obtained. The pulse width keeps nearly constant and pulse repetition rate varies with the variation of the pumping power.
Surface Effect on Oil Transportation in Nanochannel: a Molecular Dynamics Study (2017)

In this work, we investigate the dynamics mechanism of oil transportation in nanochannel using molecular dynamics simulations. It is demonstrated that the interaction between oil molecules and nanochannel has a great effect on the transportation properties of oil in nanochannel. Because of different interactions between oil molecules and channel, the center of mass (COM) displacement of oil in a 6-nm channel is over 30 times larger than that in a 2-nm channel, and the diffusion coefficient of oil molecules at the center of a 6-nm channel is almost two times more than that near the channel surface. Besides, it is found that polarity of oil molecules has the effect on impeding oil transportation, because the electrostatic interaction between polar oil molecules and channel is far larger than that between nonpolar oil molecules and channel. In addition, channel component is found to play an important role in oil transportation in nanochannel, for example, the COM displacement of oil in gold channel is very few due to great interaction between oil and gold substrate. It is also found that nano-sized roughness of channel surface greatly influences the speed and flow pattern of oil. Our findings would contribute to revealing the mechanism of oil transportation in nanochannels and therefore are very important for design of oil extraction in nanochannels.
Continuous Quantum Measurement of a Qubit State (2000)

We consider a two-level quantum system (qubit) which is continuously measured by a detector. The conventional formalism, which implies the ensemble averaging, describes the gradual decoherence of the qubit state due to measurement. However, in each particular realization of the measurement process we can have the opposite effect: gradual purification of the qubit density matrix. This can be described by the recently developed Bayesian formalism suitable for individual quantum systems. The purification effect may be verified experimentally using present day technology and can be useful for quantum computing. In particular, the decoherence of a single qubit can be suppressed using continuous measurement and the feedback loop.
Coaxial electrospinning and emulsion electrospinning of core–shell fibers (2010)

Abstract The mini‐review is devoted to coaxial electrospinning (co‐electrospinning, emulsion electrospinning), a group of novel methods for making core–shell nanofibers and hollow nanotubes. The physical aspects of the process are described in brief, in particular, its modeling and possible drawbacks of the process resulting in formation of fibers without a long intact core. After that the main applications of co‐electrospinning are considered. They include drug release, encapsulation of different biologically active compounds, cell scaffolds, formation of nanotubes, and nanofluidics. Copyright © 2010 John Wiley & Sons, Ltd.
Modern Physics, Second Edition (1962)

There ought to be a long moratorium on first year university textbooks in modern physics. There are now so many of these that their authors find it necessary to give them gimmicks to distinguish them from their elders and frequently betters.
Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino (2007)

Background: High concentrations of homocysteine have been linkedtoagreaterriskofAlzheimerdisease,dementia,andcognitive decline. Objective:Weevaluatedtheassociationbetweenhomocysteineand 4.5-y combined incidences of dementia and cognitive impairment without dementia (CIND) in a cohort of 1779 Mexican Americans aged 60–101 y. Design: Homocysteine, red blood cell (RBC) folate, and plasma vitamin B-12 were measured at baseline. New cases of dementia or CIND were ascertained by neuropsychological and clinical examinationsandexpertadjudication.Weusedproportionalhazardsmodels to estimate the risk of homocysteine-associated dementia or CIND and the influence of RBC folate and plasma vitamin B-12 on that association. Results: High homocysteine concentrations were associated with a greater risk of dementia or CIND: hazard ratio (HR): 2.39; 95% CI: 1.11, 5.16. Plasma vitamin B-12 modified the association between homocysteine and the outcome. The rates of dementia or CIND associated with homocysteine for those in the lowest and highest tertilesofvitaminB-12,respectively,weresignificantlyhigher(HR: 1.61, P 0.04) and lower (HR: 0.94, P 0.015) than the risk for those in the middle tertile. Conclusions: Homocysteine is an independent risk factor for both dementia and CIND. Higher plasma vitamin B-12 may reduce the risk of homocysteine-associated dementia or CIND. Am J Clin Nutr 2007;85:511–7.
Cyclopropylarene chemistry. IV. Homoketenyl cations in a Friedel-Crafts acylation (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclopropylarene chemistry. IV. Homoketenyl cations in a Friedel-Crafts acylationGary R. Elling, Roger C. Hahn, and Gerhard. SchwabCite this: J. Am. Chem. Soc. 1973, 95, 17, 5659–5662Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August 1973https://doi.org/10.1021/ja00798a034RIGHTS & PERMISSIONSArticle Views131Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (480 KB) Get e-Alerts Get e-Alerts
iASPP and Chemoresistance in Ovarian Cancers: Effects on Paclitaxel-Mediated Mitotic Catastrophe (2011)

Our data show an association of iASPP overexpression with gene amplification in ovarian cancer and suggest a role of iASPP in poor patient outcome and chemoresistance, through blocking mitotic catastrophe. iASPP should be explored further as a potential prognostic marker and target for chemotherapy.
Rifampin-Resistant RNA Polymerase Mutants of <i>Chlamydia trachomatis</i> Remain Susceptible to the Ansamycin Rifalazil (2005)

ABSTRACT Stable, homotypic mutants of Chlamydia trachomatis for which MICs of rifampin and rifalazil are elevated were isolated by serial passage at sub-MIC concentrations of these compounds. An alternative approach, in which Chlamydia cells were incubated and subsequently passaged three times, all in the presence of the selective agent at concentrations above the MIC, appeared to be a more effective means of selecting for mutants. In every instance where an elevation in the MIC occurred, one or more mutations in the rpoB gene, encoding the rifampin binding site, were detected. With one exception, all rpoB mutants that contained a single mutation conferred lower levels of resistance than mutants containing multiple mutations. Some rpoB mutations conferred very high levels of resistance to rifampin, up to 512 μg/ml. In all cases, mutants remained susceptible to concentrations of rifalazil at or below 0.064 μg/ml. Thus, rifalazil, a compound that is extremely potent against Chlamydia wild-type cells (MIC of 0.00025 μg/ml), may also protect against the selection of mutants at physiologically achievable concentrations.
Nano-guided cell networks as conveyors of molecular communication (2015)

Advances in nanotechnology have provided unprecedented physical means to sample molecular space. Living cells provide additional capability in that they identify molecules within complex environments and actuate function. We have merged cells with nanotechnology for an integrated molecular processing network. Here we show that an engineered cell consortium autonomously generates feedback to chemical cues. Moreover, abiotic components are readily assembled onto cells, enabling amplified and 'binned' responses. Specifically, engineered cell populations are triggered by a quorum sensing (QS) signal molecule, autoinducer-2, to express surface-displayed fusions consisting of a fluorescent marker and an affinity peptide. The latter provides means for attaching magnetic nanoparticles to fluorescently activated subpopulations for coalescence into colour-indexed output. The resultant nano-guided cell network assesses QS activity and conveys molecular information as a 'bio-litmus' in a manner read by simple optical means.
Low voltage CMOS four-quadrant multiplier (1994)

A new low voltage CMOS four-quadrant multiplier is presented. Simulation results show that, for a power supply of ±1.5 V the differential linear range is over ±0.8V with the linearity error less than 2%. The total harmonic distortion is less than 1% with the input range up to ±0.6 V. The simulated –3 dB bandwidth of this multiplier is about 12 MHz. The proposed circuit is expected to be useful in low-voltage analogue signal processing applications.
The Significance of Accurate Well Placement in the Shale Gas Plays (2010)

Abstract Unconventional shale gas reservoirs are known for low porosity, low matrix permeability, the lack of an obvious seal or trap, large regional extent, and, in most areas, are believed to be highly heterogeneous in nature. As a result, it is common practice to confirm the reservoir thickness, evaluate the shale gas rock properties and to determine horizontal shale gas targets using vertical or pilot offset wells. Horizontal wells are then drilled and stimulated to maximize reservoir exposure and enhance inflow production performance. Taking advantage of the high gamma ray activity found in most shale plays, a majority of horizontal wells are steered to stay within the defined target window using a non-azimuthal, averaged gamma ray measurement only. By relying on a single measurement, there is no fall back when the interpretation presents several possible scenarios. Additionally, a non conclusive interpretation will negatively impact the efforts of optimizing the learning curve across a field. Resistivity measurements complement gamma ray data as they provide an extra data set for correlation. However, azimuthal images from density measurements acquired in real time can offer structural dip authentication along the well trajectory to provide a higher level of accuracy to the modeled structure. By having a validated structural model, a higher level of confidence in real-time steering decisions can be gained. An accurate structural model is also an effective tool to aid completion designs, correlate formation properties, refine target delineation and provide a foundation for evaluating production logs and microseismic observations. The main objective of this paper is to demonstrate how structural modeling using only gamma ray in horizontal wells can lead to non-unique solutions that can be a potential cause of inconsistent reservoir interpretations and varied production, not only between hydraulic fracturing stages but also from well to well. Having sufficient measurements for formation evaluation, drilling and production results can be better understood and applied to enhance target selection, followed by accurate well placement within the selected target structure. This level of well placement accuracy will deliver consistent production results and provide a common platform for evaluating completion practices.
<scp>CD</scp>40‐mediated signalling influences trafficking, <scp>T</scp>‐cell receptor expression, and T‐cell pathogenesis, in the <scp>NOD</scp> model of type 1 diabetes (2017)

CD40 plays a critical role in the pathogenesis of type 1 diabetes (T1D). The mechanism of action, however, is undetermined, probably because CD40 expression has been grossly underestimated. CD40 is expressed on numerous cell types that now include T cells and pancreatic β cells. CD40<sup>+</sup> CD4<sup>+</sup> cells [T helper type 40 (TH40)] prove highly pathogenic in NOD mice and in translational human T1D studies. We generated BDC2.5.CD40<sup>-/-</sup> and re-derived NOD.CD154<sup>-/-</sup> mice to better understand the CD40 mechanism of action. Fully functional CD40 expression is required not only for T1D development but also for insulitis. In NOD mice, TH40 cell expansion in pancreatic lymph nodes occurs before insulitis and demonstrates an activated phenotype compared with conventional CD4<sup>+</sup> cells, apparently regardless of antigen specificity. TH40 T-cell receptor (TCR) usage demonstrates increases in several Vα and Vβ species, particularly Vα3.2<sup>+</sup> that arise early and are sustained throughout disease development. TH40 cells isolated from diabetic pancreas demonstrate a relatively broad TCR repertoire rather than restricted clonal expansions. The expansion of the Vα/Vβ species associated with diabetes depends upon CD40 signalling; NOD.CD154<sup>-/-</sup> mice do not expand the same TCR species. Finally, CD40-mediated signals significantly increase pro-inflammatory Th1- and Th17-associated cytokines whereas CD28 co-stimulus alternatively promotes regulatory cytokines.
English purchases of printed books from the Continent 1465–1526<sup>1</sup> (1979)

English purchases of printed books from the Continent 1465–15261 Get access ELIZABETH ARMSTRONG ELIZABETH ARMSTRONG Somerville CollegeOxford Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume XCIV, Issue CCCLXXI, April 1979, Pages 268–290, https://doi.org/10.1093/ehr/XCIV.CCCLXXI.268 Published: 01 April 1979
Glucose affects the severity of hypoxic-ischemic brain injury in newborn pigs. (1993)

Increasing serum glucose during hypoxic-ischemic injury to the newborn piglet's brain worsens brain injury.
Dispersive properties of stratified elastic and liquid media; a ray theory (1953)

Abstract The interference principle of wave guide propagation is applied to the derivation of the period equations for a number of problems involving both elastic and liquid strata. In the case of undamped steady state propagation in a solid or liquid stratum two arbitrarily chosen points at the same depth must be indistinguishable on an amplitude basis. This well known principle combined with the knowledge of the reflection coefficients enables us to derive in a few simple steps the period equations for a number of multilayer cases which heretofore had been avoided on account of algebraic difficulties. The period equations obtained by this method exhibit a singular simplicity and unity of form. As a consequence of this one may distinguish formally the M 1 and M 2 waves discovered by Sezawa and understand their physical significance.
Immune Dysfunctlon in Patients With Obstructive Jaundice, Mediators and Implications for Treatments (1997)

Patients with obstructive jaundice have an increased perioperative complication rate. Sepsis, bleeding, wound problems, renal and liver malfunction are all seen in these patients. Assessment of immune function has been an active research area in these patients. This review will examine various aspects of immune functions in obstructive jaundice, discuss the recent research results and controversies and then go on to discuss the relevant mediators of immune function and some possible implications for treatment.
Hot Surface Ignition Temperatures of Hydrocarbon Fuel Vapor-Air Mixtures. (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHot Surface Ignition Temperatures of Hydrocarbon Fuel Vapor-Air Mixtures.J. M. Kuchta, A. Bartkowiak, and M. G. ZabetakisCite this: J. Chem. Eng. Data 1965, 10, 3, 282–288Publication Date (Print):July 1, 1965Publication History Published online1 May 2002Published inissue 1 July 1965https://pubs.acs.org/doi/10.1021/je60026a023https://doi.org/10.1021/je60026a023research-articleACS PublicationsRequest reuse permissionsArticle Views361Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-dose paclitaxel, cyclophosphamide, and cisplatin with autologous hematopoietic progenitor-cell support: a phase I trial. (1996)

It is possible to escalate the dose of paclitaxel to 775 mg/m2 in combination with 5,625 mg/m2 of CPA, 165 mg/m2 of cDDP, and AHPCS. An encouraging response rate in poor-prognosis patients with breast cancer, NHL, and ovarian cancer warrants further study.
Method of improving light coupling efficiency between optical fibers and silicon waveguides (2005)

A two-dimensional taper is fabricated in rib-loaded silicon-on-insulator waveguides to couple light from high-numerical-aperture fibers. Significant improvement in coupling efficiency is achieved. There is excellent agreement between measured and calculated coupling loss values.