gebhart/patrepeval huggingface dataset:
Occupational Therapy and Motor Control (1989)

Article| Online May 01 1989 Occupational Therapy and Motor Control Helen Cohen Helen Cohen Helen Cohen, EdD, OTR, the Guest Editor of this Special Issue on Motor Control, is a Research Associate in the Department of Neurology, Mount Sinai School of Medicine, New York. (Mailing address: Department of Neurology, Box 1135, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029.) Search for other works by this author on: This Site PubMed Google Scholar Author & Article Information Online Issn: 1943-7676 Print Issn: 0272-9490 Copyright © 1989 by the American Occupational Therapy Association, Inc.1989 The American Journal of Occupational Therapy, 1989, Vol. 43(5), 289–290. https://doi.org/10.5014/ajot.43.5.289 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Helen Cohen; Occupational Therapy and Motor Control. Am J Occup Ther May 1989, Vol. 43(5), 289–290. doi: https://doi.org/10.5014/ajot.43.5.289 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Journal of Occupational Therapy Search Advanced Search Keywords: motor function This content is only available via PDF. Copyright © 1989 by the American Occupational Therapy Association, Inc.1989 Article PDF first page preview Close Modal You do not currently have access to this content.
.alpha.-Nitroarylation of ketones and esters: an exceptionally facile synthesis of indoles, 2-indolinones and arylacetic acids (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.alpha.-Nitroarylation of ketones and esters: an exceptionally facile synthesis of indoles, 2-indolinones and arylacetic acidsT. V. RajanBabu, Bertrand L. Chenard, and Michael A. PettiCite this: J. Org. Chem. 1986, 51, 10, 1704–1712Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/jo00360a014https://doi.org/10.1021/jo00360a014research-articleACS PublicationsRequest reuse permissionsArticle Views1197Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chest impedance: characteristics of local patients. (2000)

The Pre-hospital Defibrillation Program in Singapore has in some cases demonstrated a lower amplitude of Ventricular Fibrillation (VF) than considered the norm. The Electrode Skin Impedance (ESI) refers to the skin impedance determined between two electrodes placed at specific positions on the body surface. The objective of this prospective study was to measure the ESI of patients at 5 Hz and 2 kHz frequencies, and assess its change with time from the application of electrodes, the difference between the ESI at two different sets of electrode placement positions and correlation with patient factors. Patients who were 25 years or older and not critically ill had their ESI measured with a modified Heart-Save 911 defibrillator, using signal frequencies at 5 Hz and 2 kHz, at 10 seconds, 1 and 2 minutes after electrodes application. Two sets of positions were used; Position 1 where an electrode is placed in the right infra-clavicular region and another just lateral to the apex beat on the left and Position 2, which represents the mirror image of Position 1. 36 each of male and female patients were studied. The mean age and weight were 59.9 +/- 13.5 years and 56.8 +/- 24.1 kg respectively. There was no significant correlation between the ESI and patients' body weight or sex. However, there was a significant decrease in the ESI with time from application of electrodes at both Positions (p < 0.05) with the two different frequencies. The ESI was lower when measured at lower frequencies and higher when taken at higher frequencies, but there was no statistically significant difference between the two mirror-image positions used. Thus, with lower frequency, the ECG amplitude of VF recorded on the automated external defibrillator could be enhanced.
Bioactive alkaloids in vertically transmitted fungal endophytes (2013)

Summary Plants form mutualistic symbioses with a variety of microorganisms including endophytic fungi that live inside the plant and cause no overt symptoms of infection. Some endophytic fungi form defensive mutualisms based on the production of bioactive metabolites that protect the plant from herbivores in exchange for a protected niche and nutrition from the host plant. Key elements of these symbioses are vertical transmission of the fungus through seed of the host plant, a narrow host range, and production of bioactive metabolites by the fungus. Grasses frequently form symbioses with endophytic fungi belonging to the family C lavicipitaceae. These symbioses have been studied extensively because of their significant impacts on insect and mammalian herbivores. Many of the impacts are likely due to the production of four classes of bioactive alkaloids – ergot alkaloids, lolines, indole‐diterpenes and peramine – that are distributed in different combinations among endophyte taxa. Several legumes, including locoweeds, are associated with a toxic syndrome called locoism as a result of their accumulation of swainsonine. Species in two genera were recently found to contain previously undescribed endophytic fungi ( U ndifilum spp., family P leosporaceae) that are the source of that toxin. The fungi are strictly vertically transmitted and have narrow host ranges. Some plant species in the morning glory family ( C onvolvulaceae) also form symbioses with endophytic fungi of the C lavicipitaceae that produce ergot alkaloids and, perhaps in at least one case, lolines. Other species in this plant family form symbioses with undescribed fungi that produce swainsonine. The swainsonine‐producing endophytes associated with the C onvolvulaceae are distinct from the U ndifilum spp. associated with locoweeds and the C lavicipitaceous fungi associated with Convolvulaceae. In the establishment of vertically transmitted symbioses, fungi must have entered the symbiosis with traits that were immediately useful to the plant. Bioactive metabolites are likely candidates for such pre‐adapted traits which were likely useful to the free‐living fungi as well. With future research, vertically transmitted fungi from diverse clades with narrow host ranges and that produce bioactive compounds are likely to be found as important mutualists in additional plants.
Merit or Misogyny: Women in Australian Politics (2019)

This essay analyses the masculine nature of Australian politics, in particular looking at the under representation of women within the Liberal and Labor parties. The debate between the establishment of quotas for female candidates or the selection of candidates on the basis of merit and what exactly defines merit will be examined. The essay will investigate how merit is in fact a gendered term by looking at the leadership spill within the Liberal Party in August 2018 which saw Scott Morrison emerge as leader triumphing over Peter Dutton and Julie Bishop. The gendered nature of merit will be explored by looking at the leadership ballot and why Julie Bishop received just 11 votes despite outperforming her opponents in recent polling and having a superior resume, allegations of bullying by a number of female Liberal Members of Parliament will also be examined. The works of a number of feminist theorists will be drawn upon throughout the analysis, in particular the work of Catharine MacKinnon in Towards a Feminist Theory of the State.
Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells (2010)

Emerging studies have identified microRNAs (miRNAs) as possible therapeutic tools for the treatment of glioma, the most aggressive brain tumor. Their important targets in this tumor are not well understood. We recently found that the Notch pathway is a target of miRNA-326. Ectopic expression of miRNA-326 in glioma and glioma stem cells induced their apoptosis and reduced their metabolic activity. Computational target gene prediction revealed pyruvate kinase type M2 (PKM2) as another target of miRNA-326. PKM2 has recently been shown to play a key role in cancer cell metabolism. To investigate whether it might be a functionally important target of miR-326, we used RNA interference to knockdown PKM2 expression in glioma cells. Transfection of the established glioma and glioma stem cells with PKM2 siRNA reduced their growth, cellular invasion, metabolic activity, ATP and glutathione levels, and activated AMP-activated protein kinase. The cytotoxic effects exhibited by PKM2 knockdown in glioma and glioma stem cells were not observed in transformed human astrocytes. Western blot analysis of human glioblastoma specimens showed high levels of PKM2 protein, but none was observed in normal brain samples. Strikingly, cells with high levels of PKM2 expressed lower levels of miR-326, suggestive of endogenous regulation of PKM2 by miR-326. Our data suggest PKM2 inhibition as a therapy for glioblastoma, with the potential for minimal toxicity to the brain.
Modeling greenhouse gas emissions from dairy farms (2017)

Dairy farms have been identified as an important source of greenhouse gas emissions. Within the farm, important emissions include enteric CH<sub>4</sub> from the animals, CH<sub>4</sub> and N<sub>2</sub>O from manure in housing facilities during long-term storage and during field application, and N<sub>2</sub>O from nitrification and denitrification processes in the soil used to produce feed crops and pasture. Models using a wide range in level of detail have been developed to represent or predict these emissions. They include constant emission factors, variable process-related emission factors, empirical or statistical models, mechanistic process simulations, and life cycle assessment. To fully represent farm emissions, models representing the various emission sources must be integrated to capture the combined effects and interactions of all important components. Farm models have been developed using relationships across the full scale of detail, from constant emission factors to detailed mechanistic simulations. Simpler models, based upon emission factors and empirical relationships, tend to provide better tools for decision support, whereas more complex farm simulations provide better tools for research and education. To look beyond the farm boundaries, life cycle assessment provides an environmental accounting tool for quantifying and evaluating emissions over the full cycle, from producing the resources used on the farm through processing, distribution, consumption, and waste handling of the milk and dairy products produced. Models are useful for improving our understanding of farm processes and their interacting effects on greenhouse gas emissions. Through better understanding, they assist in the development and evaluation of mitigation strategies for reducing emissions and improving overall sustainability of dairy farms.
Chemical research fraud uncovered in Germany (1994)

RETURN TO ISSUEPREVNewsNEXTChemical research fraud uncovered in GermanySTEPHEN STINSONCite this: Chem. Eng. News 1994, 72, 26, 7–8Publication Date (Print):June 27, 1994Publication History Published online11 November 2010Published inissue 27 June 1994https://pubs.acs.org/doi/10.1021/cen-v072n026.p007https://doi.org/10.1021/cen-v072n026.p007newsACS PublicationsCopyright © 1994 AMERICAN CHEMICAL SOCIETYArticle Views42Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Magnetic properties Get e-Alerts
A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C (2012)

Caspase-6 is a cysteinyl protease implicated in neurodegenerative conditions including Alzheimer's and Huntington's disease making it an attractive target for therapeutic intervention. A greater understanding of the role of caspase-6 in disease has been hampered by a lack of suitable cellular assays capable of specifically detecting caspase-6 activity in an intact cell environment. This is mainly due to the use of commercially available peptide substrates and inhibitors which lack the required specificity to facilitate development of this type of assay. We report here a 384-well whole-cell chemiluminescent ELISA assay that monitors the proteolytic degradation of endogenously expressed lamin A/C during the early stages of caspase-dependent apoptosis. The specificity of lamin A/C proteolysis by caspase-6 was demonstrated against recombinant caspase family members and further confirmed in genetic deletion studies. In the assay, plasma membrane integrity remained intact as assessed by release of lactate dehydrogenase from the intracellular environment and the exclusion of cell impermeable peptide inhibitors, despite the induction of an apoptotic state. The method described here is a robust tool to support drug discovery efforts targeting caspase-6 and is the first reported to specifically monitor endogenous caspase-6 activity in a cellular context.
Conjugated polyene fatty acids as membrane probes: preliminary characterization. (1975)

The use of fluorescent conjugated polyenoic fatty acids as probes of membrane structure is introduced. alpha- and beta-parinaric acid (cis, trans, trans, cis-, and all trans-9,11,13,15-octadecatetraenoic acid) and synthetic lecithins containing an alpha-parinaric acid chain in position 2 are prepared and their absorption and fluorescence properties are determined. Phase transitions are detected as fluorescence changes at characteristic temperatures when either the free fatty acid probes or the labeled phospholipid probe are included in sonicated aqueous dispersions of L-alpha-dimyristoyl lecithin, L-alpha dipalmitoyl lecithin, or L-alpha-distearoyl lecithin. The phase transitions are detected at about 23 degrees C (dimyristoyl), 44 degrees C (dipalmitoyl), and 53 degrees C (distearoyl lecithin). Binding of alpha-parinaric acid to bovine serum albumin is measured by shifts in the absorption spectrum and enhanced quantum yield of the fatty acid upon binding and by energy transfer between 2 tryptophyl residues in bovine serum albumin and alpha-parinaric acid. Approximately six binding sites are detected. Other applications of these probe molecules, including phase transitions of phospholipid/cholesterol dispersions, induced circular dichroism of parinaric acid bound to albumin, and biosynthetic incorporation of parinaric acid into biological membranes, are discussed.
Anxiety and pain: attentional and endorphinergic influences (1996)

The role of attentional mechanisms and endogenous opioids in the influence of anxiety on acute pain sensation was investigated. Forty-five spider phobics received mildly painful electrical stimulation. The opioid antagonist naltrexone or placebo was administered between subjects to examine an analgesia due to anxiety-induced endorphinergic activity, while anxiety and focus of attention were manipulated within subjects. In accordance with previous research, pain ratings and skin conductance responses (SCRs) were not influenced by anxiety when focus of attention was controlled for. Attention towards pain led to an increase in subjective pain as opposed to distraction from pain. SCRs, however, were increased in the distraction conditions, probably due to heightened unexpectedness. Further, both high and low anxiety resulted in an analgesia compared to the pretest in the placebo condition, which was reversed by a low dose of naltrexone, but not by a high dose. Apart from possible agonist properties of high doses of naltrexone, this effect suggests an opioid-induced analgesia. It remains to be demonstrated whether this was due to endogenous opioids released during high anxiety.
Explainable cardiac pathology classification on cine MRI with motion characterization by semi-supervised learning of apparent flow (2018)

We propose a method to classify cardiac pathology based on a novel approach to extract image derived features to characterize the shape and motion of the heart. An original semi-supervised learning procedure, which makes efficient use of a large amount of non-segmented images and a small amount of images segmented manually by experts, is developed to generate pixel-wise apparent flow between two time points of a 2D+t cine MRI image sequence. Combining the apparent flow maps and cardiac segmentation masks, we obtain a local apparent flow corresponding to the 2D motion of myocardium and ventricular cavities. This leads to the generation of time series of the radius and thickness of myocardial segments to represent cardiac motion. These time series of motion features are reliable and explainable characteristics of pathological cardiac motion. Furthermore, they are combined with shape-related features to classify cardiac pathologies. Using only nine feature values as input, we propose an explainable, simple and flexible model for pathology classification. On ACDC training set and testing set, the model achieves 95% and 94% respectively as classification accuracy. Its performance is hence comparable to that of the state-of-the-art. Comparison with various other models is performed to outline some advantages of our model.
Faster Determination of Mass-Averaged SAR From 2-D Area Scans (2004)

An algorithm is presented that accurately and quickly estimates the peak 1or 10-g averaged specific absorption rate (SAR) in a human phantom when exposed to a wireless device. Instead of performing both an area scan and a zoom scan (as per international standards), only the area scan and knowledge of the transmit frequency are needed. The accuracy of the algorithm has been demonstrated across a broad frequency range (150-2450 MHz) and for both 1- and 10-g averaged SAR using a sample of 264 SAR measurements from 55 wireless handsets. For the sample size studied, the root-mean-squared errors of the algorithm are 1.2% and 5.8% for 1- and 10-g averaged SAR, respectively. It is shown that the algorithm works well in both head and body phantoms.
Liquid crystals for optical readout IR imaging (2010)

It has long been proven that pyro-optical properties can be used to develop high performance IR detectors without making use of a microelectronic readout circuit. In this application, the sensing materials should have high pyro-optic coefficient, or the refractive index of the materials should have strong dependence on temperature. Polymers showed higher pyro-optic coefficient compared with that of most inorganic materials. Among the polymers, liquid crystals (LCs) attracted more interests for their stronger temperature dependent optical characteristics. In this study, 5CB and 3HHV LCs were selected as examples to investigate their pyro-optic properties for the development of optical readout IR imaging devices. Refractive indices of the 5CB LC for both ordinary and extrodinary light were characterized within the phase transition temperature range. It was found that the no changed slightly with the variation of temperature, while the ne changed dramatically with the change of temperature. For 5CB, when the temperature increased from 22°C to 34 °C, n<sub>e</sub> decreased from 1.75 to 1.64 for wavelength of 632.8nm. Results for 3HHV were also reported and analyzed. Another interesting property of the 5CB was that it showed obvious IR absorption in the wavelength range between 3 and 5 μm, which made them more promising for the application as IR sensing materials.
Lead-Selective Electrodes Based on Calixarene Phosphine Oxide Derivatives (1999)

We have discovered that a series of calixarene phosphine oxide derivatives can produce ion-selective electrodes with excellent response characteristics to the Pb2+ ion. These ligands were previously known to complex lanthanides, but their complexation behavior with transition metal ions and group I/group II ions is relatively unexplored. The extreme stability of these compounds, coupled with interesting selectivity behavior, make them attractive contenders for use in potentiometric poly(vinyl chloride) membrane electrodes. Results show near-Nernstian responses to Pb2+ for electrodes based on three ligands (p-tert-butylcalix[n]arene ethyleneoxydiphenylphosphine oxide, n = 4, 5, 6) and excellent selectivity against a wide range of common interferences. Ca2+ was found to be the most important interference, but its impact dramatically decreased as the cavity size increased from the tetramer (n = 4) through the pentamer (n = 5) to the hexamer (n = 6). Electrodes based on the hexamer were found to have characteristics superior to similar devices based on several commercially available Pb2+-selective ligands. The importance of the calixarene macrocyclic backbone on the selectivity is highlighted by the poor selectivity of the electrode based on triphenylphosphine oxide. Molecular modeling has been used to provide some insight into the observed selectivity.