gebhart/patrepeval huggingface dataset:
PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus (2006)

Progesterone receptor (PR) plays a critical role in cell proliferation and differentiation, and its transcriptional activity is known to be modulated by cofactor proteins. In the present study, we demonstrated that in the presence of progesterone, protein inhibitor of activated STAT-3 (PIAS3) significantly inhibited the PR transcriptional activity and the expression of progesterone-responsive genes. Reduction of endogenous PIAS3 by PIAS3 small-interfering RNA enhanced PR transactivation in a ligand-dependent manner. PIAS3 interacted with PR both in vitro and in vivo and the interaction was enhanced by progesterone. Furthermore, our findings suggested that PIAS3 strongly induced PRB sumoylation at three sites, Lys-7, Lys-388 and Lys-531. In addition, novel roles in PRB nuclear retention and transactivation were identified for these sites. Our data also suggested that PIAS3 was recruited in a largely hormone-dependent manner in response to a progesterone-responsive promoter. Finally, we demonstrated that PIAS3 inhibited the DNA-binding activity of PR and influenced its nuclear export as well as PR transactivation. Taken together, these data strongly suggested that PIAS3 played an important physiological role in PR function.
Influence of Monoglycerides on the Gelatinization and Enzymatic Breakdown of Wheat and Cassava Starch (1976)

Abstract The influence of monoglycerides on the flocculation and gelatinization of suspensions of wheat starch and cassava starch was studied. The sedimentation volumes of native and gelatinized starch with and without added monoglycerides were measured and the quantity of bound monoglycerides was determined. The sediments were examined by scanning electron microscopy and the rate of enzymatic breakdown by α‐amylase was determined.
KINECT applications for the physical rehabilitation (2013)

This report presents the results of KINECT applications used in physical rehabilitation tests. Aoyama Gakuin and Kitasato universities collaborated on this project, which is supported by SCOPE. The applications, following standard tests, are for the timed “Up & Go Test”, the timed “10-Meter Walk Test” and for a Joint “Range of Motion” Measurement”; test results are given. The implementation, evaluation and advantages of a proposed “Real-time ROM Measurement” are also given. The proposed KINECT application will be useful for enhancement of KINECT technical capabilities and for further advancements in medical care.
A 16 mW 30 MSample/s 10 b pipelined A/D converter using a pseudo-differential architecture (2003)

The authors present a 16 mW 2 V 30 MSample/s 10 b pipelined A/D converter in 0.3 /spl mu/m CMOS technology which uses a pseudo-differential architecture and a capacitor cross-coupled S/H stage. SNDR and the SFDR at 30 MHz input are 54 dB and 67 dB, respectively.
Performance analysis of the IEEE 802.1 ethernet audio/video bridging standard (2012)

Switched Ethernet is widely used for all kinds of applications. However, for demanding multimedia streaming applications in a fully-loaded network, legacy Ethernet is not the best choice due to its limited Quality-of-Service (QoS) support. The new specification of the IEEE 802.1 Audio/Video Bridging (AVB) standard, an extension to legacy Ethernet, provides the QoS features needed for multimedia streaming: Time synchronized low latency streaming services and bandwidth reservation on Layer-2. In this work, we study and analyze the AVB standard based on a simulation approach to verify the specified constraints and to determine the feasibility of the mechanisms in a switched Ethernet network. We use the simulation tool OMNeT++ and extend the existing INET-framework to support all the required protocols specified in the IEEE 802.1 AVB standard.
<i>PEP4</i> GENE FUNCTION IS REQUIRED FOR EXPRESSION OF SEVERAL VACUOLAR HYDROLASES IN <i>SACCHAROMYCES CEREVISIAE</i> (1982)

The pep4-3 mutation results in a 90-95% reduction in the levels of five vacuolar hydrolases in yeast, including proteinases A and B, carboxypeptidase Y, RNase(s) and the repressible alkaline phosphatase. The mutation is without effect on two secreted glycoproteins, on an enzyme of the vacuolar membrane, and on a proteinase located outside of the vacuole. Mutations at the PEP4 locus exhibit a dosage effect on the levels of some, but not all, of the enzymes whose expression requires the function of the gene.
Generation of high-energy plasmas by electromagnetic implosion (1973)

Multimegajoule high-temperature high-Z plasmas are of interest as high-intensity radiation sources for use in a number of applications. This paper describes a possible method of generating such plasmas by means of the j × B driven implosion of thin metallic foil cylinders. Basic analytical guidelines are developed and the results of numerical computations are displayed. Experimental problems associated with the creation of high-energy plasmas by this technique are discussed with some initial experimental results presented.
Mild and Practical Method for the α-Arylation of Nitriles with Heteroaryl Halides (2005)

[reaction: see text] A mild and transition-metal-free method for the alpha-arylation of aliphatic nitriles with activated heteroaryl halides was developed using NaHMDS or KHMDS as base at ambient temperature. The key to the success of this method is generation of the nitrile anion in the presence of the heteroaryl halide. The method is applicable to both primary and secondary carbonitriles and a wide range of heteroaryl halides. Selective monoarylation was observed with primary carbonitriles. The operational simplicity and the mild reaction conditions add to the value of this method as a practical alternative to the preparation of alpha-heteroaryl carbonitriles.
Invasive hemodynamic evaluation in patients with mechanical aortic valves (2013)

Invasive hemodynamic evaluation in the patient with a mechanical aortic valve has in the past required transseptal or apical left ventricular puncture in order to obtain left ventricular pressure measurements. Over the last few years, several case reports have described the feasibility of using a coronary pressure-sensing guidewire to cross mechanical prosthetic aortic valves. In the current manuscript, we report four cases in which the use of a pressure-sensing guidewire was utilized for invasive hemodynamic diagnostic evaluation in patients with mechanical aortic valves. Furthermore, we present a detailed description of the technical approach to this technique and the limitations of this approach.
<i>An Overview:</i> Vapor Phase Corrosion Inhibitors (2000)

When present as vapors, certain organic compounds offer inhibition against the corrosion of ferrous and nonferrous materials. The inhibitors include aliphatic, aromatic, cyclohexylamines, aminonitrobenzoates, heteroalkylated lower amines, etc. The mechanism of inhibition offered by these compounds was discussed and an unified mechanism was presented. Various methods of evaluating inhibition efficiency were discussed with a special reference to surface film characterization techniques. Methods of application of the vapor phase inhibitors and their industrial uses also were presented.
Seven‐Membered Hetarenes with Two or More Heteroatoms (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
A multimodal variational approach to learning and inference in switching state space models (2004)

An important general model for discrete-time signal processing is the switching state space (SSS) model, which generalizes the hid-den Markov model and the Gaussian state space model. Inference and parameter estimation in this model are known to be computa-tionally intractable. This paper presents a powerful new approxi-mation to the SSS model. The approximation is based on a vari-ational technique that preserves the multimodal nature of the con-tinuous state posterior distribution. Furthermore, by incorporating a windowing technique, the resulting EM algorithm has complex-ity that is just linear in the length of the time series. An alterna-tive Viterbi decoding with frame-based likelihood is also presented which is crucial for the speech application that originally motivates this work. Our experiments focus on demonstrating the effective-ness of the algorithm by extensive simulations. A typical example in speech processing is also included to show the potential of this approach for practical applications. 1.
Fetal Pulse Oximetry (1999)

In Brief Objective To analyze labor outcomes in relation to masked fetal arterial oxyhemoglobin saturation values above or below 30%. Methods Consenting gravidas with uncomplicated pregnancies at or beyond 36 weeks' gestation underwent continuous fetal pulse oximetry. Pregnancy outcomes were compared between two groups: women with fetuses with at least one epoch of arterial oxyhemoglobin saturation below 30% (10 seconds or longer) and women with fetuses without such an episode. We also attempted to ascertain whether duration of saturation below 30% correlated with fetal compromise. Results We measured arterial oxyhemoglobin saturation in 129 fetuses, 69 (53%) of whom had at least one epoch of saturation below 30%. There were no statistically significant differences in labor and delivery outcomes between the high-saturation and low-saturation groups (eg, cesarean delivery: 13 versus 9%, P = .41; umbilical artery [UA] pH less than 7.20: 10 versus 9%, P > .999). However, as duration of fetal arterial oxyhemoglobin saturation below 30% increased from 10 seconds to longer than 9 consecutive minutes, the incidence of fetal compromise (considered present when at least one of the following criteria was met: cesarean delivery for nonreassuring fetal heart rate pattern, UA pH less than 7.20, admission to the special care nursery, or 5-minute Apgar score not more than 3) increased significantly (P = .002). The threshold duration of fetal arterial oxyhemoglobin saturation below 30% associated with increased fetal compromise was 2 minutes. Conclusion Transient fetal arterial oxyhemoglobin saturation values below 30% are common during normal labor and did not predict fetal compromise. Fetal arterial oxyhemoglobin saturation values less than 30% for 2 minutes or longer might be associated with fetal compromise. The duration of fetal arterial oxyhemoglobin saturation below 30%, measured by continuous fetal pulse oximetry, might identify fetal compromise.
An immunohistochemical study of cyclin-dependent kinase 5 (CDK5) expression in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC): a possible prognostic biomarker (2015)

The results of this present study suggest that the CDK5 expression is associated with several clinicopathological factors linked with poorer prognosis.
Consumer responses to shelf out‐of‐stocks of perishable products (2007)

Purpose This paper aims to identify customer behavior with regard to out‐of‐stocks (OOS) of perishable products (focused on bakery bread) and the resulting inventory performance for these perishable products. Design/methodology/approach Insights on how consumers behave when their preferred bread product is OOS are derived based on 3,800 customer interviews performed in three stores of a large Dutch grocery retail chain. Next to this, additional logistical information was measured on regular moments with respect to the shelf availability per stock‐keeping unit during the day and to waste at the end of the day. Findings The customer behavior with regard to perishables is observed to be different from that for the non‐perishable items. The key observation is that customers have a high willingness to substitute. The incorporation of the obtained knowledge of the observed consumer buying behavior into the existing automated store ordering (ASO) systems is discussed. In the current ASO systems, no distinction is made between perishable and non‐perishable products, as it is primarily designed and used for the non‐perishables. The authors show that the current ASO can be enriched and extended by taking into account some extra crucial parameters which are based on the observed consumer behavior. Originality/value One common factor in the research papers published so far is that they primarily looked into the customer behavior for non‐perishable items. The current paper on‐hand extends these works towards perishable items with a focus on bakery bread.
Ring-Opening Homo- and Copolymerization of α-Methylene-ε-caprolactone (2006)

The ring-opening polymerization of α-methylene-ε-caprolactone (α-MCL) is presented for the first time. Poly(α-MCL) was characterized by 1H NMR, GPC, DSC, and MALDI-TOF. The ring-opening copolymerization of α-MCL with ε-caprolactone (ε-CL) yields to formation of radically cross-linkable poly(ε-CL)s with melting points in the range of 35−54 °C depending on the copolymer composition.
Cyclic Alternating Pattern as a Provocative Factor in Nocturnal Paroxysmal Dystonia (1997)

The modulatory role of CAP on nocturnal motor events is reported.
Platelet-activating factor enhances urokinase-type plasminogen activator gene expression in corneal epithelium. (1996)

After corneal injury and inflammation, PAF may be an important initiator of the proteolytic cascade, leading to epithelial defects and corneal ulceration. Antagonists of PAF could be useful in the prevention of these diseases.
The Algorithms That Make Instacart Roll: How Machine Learning And Other Tech Tools Guide Your Groceries From Store To Doorstep (2021)

IT'S SUNDAY MORNING, and, after your socially distanced morning hike, you look at your schedule for the next few days. You need to restock your refrigerator, but the weekend crowds at the supermarket don't excite you. Monday and Tuesday are jam-packed with Zoom meetings, and you'll also be supervising your children's remote learning. In short, you aren't going to make it to the grocery store anytime soon. So you pull out your phone, fire up the Instacart app, and select your favorite grocery store. You click through your list of previously purchased items, browse specials, search for a new key-lime sparkling water a friend recommended, then select a delivery window. About 2 hours later, you watch a shopper, wearing a face mask, place bags on your porch.
Luminescent metal complexes. Part 1. Tris-chelates of substituted 2,2′-bipyridyls with ruthenium (<scp>II</scp>) as dyes for luminescent solar collectors (1984)

Ruthenium(II) and osmium(II) complexes of 2,2′-bipyridyls (bipy) and 1,10-phenanthrolines (phen) are identified as feasible dyes for use in luminescent solar collectors. Twenty-seven RuII(bipy)32+ complexes are prepared and the absorption and emission spectra of their solutions in EtOH–MeOH at room temperature are reported. Quantum efficiencies, Which are sensitive to oxygen quenching, vary between 0.002 and 0.306 depending upon substituents. The effect of the medium on the spectral properties of selected compounds has also been investigated. Measured quantum yields of non-aqueous solutions are higher than those for aqueous solutions but lower than for doped plastic films.
The Removal of Wall Components in Doppler Ultrasound Signals by Using the Empirical Mode Decomposition Algorithm (2007)

Doppler ultrasound systems, used for the noninvasive detection of the vascular diseases, normally employ a high-pass filter (HPF) to remove the large, low-frequency components from the vessel wall from the blood flow signal. Unfortunately, the filter also removes the low-frequency Doppler signals arising from slow-moving blood. In this paper, we propose to use a novel technique, called the empirical mode decomposition (EMD), to remove the wall components from the mixed signals. The EMD is firstly to decompose a signal into a finite and usually small number of individual components named intrinsic mode functions (IMFs). Then a strategy based on the ratios between two adjacent values of the wall-to-blood signal ratio (WBSR) has been developed to automatically identify and remove the relevant IMFs that contribute to the wall components. This method is applied to process the simulated and clinical Doppler ultrasound signals. Compared with the results based on the traditional high-pass filter, the new approach obtains improved performance for wall components removal from the mixed signals effectively and objectively, and provides us with more accurate low blood flow.
Optical simulation and optimization of weak-microcavity tandem white organic light-emitting diodes (2014)

We systematically studied the influence of weak microcavity effects on the optical properties of tandem white organic light-emitting diodes (WOLEDs) using optical simulation. Based on the simulation results, an image processing method is developed and verified for rational design of high-performance tandem WOLEDs. The results indicate that low operating voltage, good color rendering index, and angular emission properties can be simultaneously obtained in tandem WOLEDs by engineering the device structure. This study provides promising direction for the development of high-performance tandem WOLEDs.
Authentication system deployment throughout protected access (UTM) for the Wireless Network in a hotel chain (2011)

A Hotel chain distributed over Europe wishes to provide wireless access to Internet for the hosted customers and offer an integral security through a Unified Threat Management ( UTM )
The project will consist; in one hand, based on the customer's needs, on adding a wireless access, with a captive portal authentication centralized at our company being able to manage users as well as the wireless networks remotely.
On the other hand, the securization and management of the communication lines will be handled by an extended UTM platform with integrated functions such as Firewall, Virtual Private Network, Web Filter, Traffic Shaping and Application Control amongst others.
Bell's Palsy: The Spontaneous Course of 2,500 Peripheral Facial Nerve Palsies of Different Etiologies (2002)

A survey of the literature showed that no kind of treatment, including prednisone, was able to give a better prognosis. The use of prednisone raises a big ethical problem because no evidence of its efficacy exists and the euphoric side-effect induces a false feeling of benefit in the patients.
Epidural metastases in prospectively evaluated veterans with cancer and back pain (1989)

Ninety-five male veterans with cancer and back pain were prospectively evaluated for epidural metastases. The evaluation included vertebral roentgenograms and a myelogram. The most common cancers were lung and prostate. Forty-three percent of the patients had an epidural metastasis, including 73% of the 37 patients with myelopathy and 48% of the 29 patients with radiculopathy. None of the 29 patients who had back pain without radiculopathy or myelopathy had an epidural metastasis. Thirty-seven patients were treated with only radiation therapy and dexamethasone and four also had surgical decompression. Nineteen of the 20 patients who could walk at diagnosis walked after completion of therapy, whereas, only 11 of the 21 patients who were not ambulatory at the time of diagnosis walked after completion of therapy. The probability of surviving 12 months was 73% for patients who could walk after treatment and 9% for nonambulatory patients. Emergency spinal canal imaging is warranted in cancer patients with back pain and signs or symptoms of radiculopathy or myelopathy.
Enterotoxin A Synthesis in Staphylococcus aureus: Inhibition by Glycerol and Maltose (1986)

Studies indicated that prior growth of Staphylococcus aureus 196E on glycerol or maltose led to cells with repressed ability to produce staphylococcal enterotoxin A (SEA). A PTS- mutant (196E-MA) lacking the phosphoenolpyruvate phosphotransferase system (PTS), derived from strain 196E, showed considerably less repression of SEA synthesis when cells were grown in glycerol or maltose. Since SEA synthesis is not repressed in the PTS- mutant, repression of toxin synthesis by glycerol, maltose or glucose in S. aureus 196E appears to be related to the presence of a functional PTS irrespective of whether the carbohydrate requires the PTS for cell entry. With lactose as an inducer, glucose, glycerol, maltose or 2-deoxyglucose repressed the synthesis of beta-galactosidase in S. aureus 196E. It is postulated that these compounds repress enzyme synthesis by an inducer exclusion mechanism involving phosphorylated sugar intermediates. However, inducer exclusion probably does not explain the mechanism of repression of SEA synthesis by carbohydrates.
PD-1 blockade modulates chimeric antigen receptor (CAR)–modified T cells: refueling the CAR (2016)

2] We report a case in which a PD-1 blocking antibody was administered to a patient with refractory diffuse large B-cell lymphoma (DLBCL) and progressive lymphoma after therapy with CAR-modified T cells directed against CD19 (CART19). Following PD-1 blockade, the patient had a clinically significant antitumor response, an expansion of CART19 cells, and decreased coexpression of PD-1 and Eomes by CART19 cells. This case suggests that PD-1 blockade can be effective against cancers failing to respond to CAR-modified T-cell therapy.
Modelled Object Pose Estimation and Tracking by Monocular Vision (1993)

This paper presents a new method that permits to solve the problem of determination of a modelled 3D-object spatial attitude from a single perspective image and to compute the covariance matrix associated to the attitude parameters. Its principle is based on the interpretation of at least three segments as the perspective projection of linear ridges of the object model and on the iterative search ( using Kalman filtering) of the model attitude consistent with these projections. The knowledge of the attitude and of the associated covariances enables to use a higher level Kalman filter to track an object along an image sequence. In the tracking process this Kalman filter is used to predict the attitude of the object and the error matrices are used to make robust automatic matches between the image segments and the model ridges. Tracking experiments have been made that proves the validity of this approach. This work has been partially supported by a contract with the European Spatial Agency (ESA) in which society Sagem is the prime contractor.
A NFA-based programmable regular expression match engine (2009)

In this poster, we present a programmable hardware architecture to speed up the matching of regular expressions. The match engine is modeled as non-deterministic finite automata (NFA) with auxiliary hardware features to process repetition of sub-patterns without unrolling. The computation is table-driven and the system throughput is deterministic. The lookup tables are implemented using ternary content addressable memory (TCAM). The overall table size is approximately equal to the number of transition edges in the NFA. Incremental changes to the pattern set can be accommodated by modifying the contents of the lookup tables without reconfiguring the hardware.
Kinetics and Photodegradation Study of Aqueous Methyl<i>tert</i>-Butyl Ether Using Zinc Oxide: The Effect of Particle Size (2013)

Zinc oxide of different average particle sizes 25 nm, 59 nm, and 421 nm as applied in the photodegradation of MTBE. This study was carried out in a batch photoreactor having a high pressure mercury lamp. Zinc oxide of particle size of 421 nm was found to be the most effective in degrading MTBE in an aqueous solution. On using this type of ZnO in a solution of 100 ppm MTBE, the concentration of MTBE has decreased to 5.1 ppm after a period of five hours. The kinetics of the photocatalytic degradation of MTBE was found to be a first order reaction.
''Design of RF Front End for Multi-Band Multi-System GNSS Receiver'' (2008)

The up growing wireless communication field always need such a system which is simple but more reliable for multiple applications. To fulfill these demands the modern receiver RF frontend can play ...