gebhart/patrepeval huggingface dataset:
Morphological Alteration of Temporal Lobe Gray Matter in Dyslexia: An MRI Study (2000)

Functional imaging studies of developmental dyslexia have reported reduced task-related neural activity in the temporal and inferior parietal cortices. To examine the possible contribution of subtle anatomic deviations to these reductions, volumes were measured for the major lobes of the brain, the subcortical nuclei, cerebellum, and lateral ventricles on magnetic resonance imaging (MRI) scans from 16 right-handed dyslexic men, ages 18 to 40, and 14 matched controls, most of whom had previously undergone PET imaging. A specific decrease in tissue volume was localized to the temporal lobes and was particularly prominent on the left (p < .01). An analysis of tissue composition revealed that this reduction was primarily attributable to decreased gray matter within the left temporal lobe (p < .002). Further segmentation of the temporal lobe showed that this reduction was not confined to the superior temporal gyrus, the primary location of primary auditory cortex. Reductions of temporal lobe gray matter may reflect a regional decrease in neuronal number or neuropil, which in turn may result in reading impairment.
Low-Dose Bone Morphogenetic Protein-2/Stromal Cell-Derived Factor-1β Cotherapy Induces Bone Regeneration in Critical-Size Rat Calvarial Defects (2013)

Increasing evidence suggests that stromal cell-derived factor-1 (SDF-1/CXCL12) is involved in bone formation, though underlying molecular mechanisms remain to be fully elucidated. Also, contributions of SDF-1β, the second most abundant splice variant, as an osteogenic mediator remain obscure. We have shown that SDF-1β enhances osteogenesis by regulating bone morphogenetic protein-2 (BMP-2) signaling in vitro. Here we investigate the dose-dependent contribution of SDF-1β to suboptimal BMP-2-induced local bone formation; that is, a dose that alone would be too low to significantly induce bone formation. We utilized a critical-size rat calvarial defect model and tested the hypotheses that SDF-1β potentiates BMP-2 osteoinduction and that blocking SDF-1 signaling reduces the osteogenic potential of BMP-2 in vivo. In preliminary studies, radiographic analysis at 4 weeks postsurgery revealed a dose-dependent relationship in BMP-2-induced new bone formation. We then found that codelivery of SDF-1β potentiates suboptimal BMP-2 (0.5 μg) osteoinduction in a dose-dependent order, reaching comparable levels to the optimal BMP-2 dose (5.0 μg) without apparent adverse effects. Blocking the CXC chemokine receptor 4 (CXCR4)/SDF-1 signaling axis using AMD3100 attenuated the osteoinductive potential of the optimal BMP-2 dose, confirmed by qualitative histologic analysis. In conclusion, SDF-1β provides potent synergistic effects that support BMP-induced local bone formation and thus appears a suitable candidate for optimization of bone augmentation using significantly lower amounts of BMP-2 in spine, orthopedic, and craniofacial settings.
ANALISIS Y DISEÑO DE SISTEMA DE INFORMACIÓN PARA LA GESTION DE HOTELERÍA “DOMINGO SAVIO”. PLAN ESTRATÉGICO PARA LA IMPLEMENTACIÓN DEL SISTEMA DE GESTIÓN DE HUESPEDES (2005)

espanolEn un contexto cambiante, las empresas necesitan realizar nuevas competencias y tener una cosmovision in-out de sus organizaciones. Esto exige actitudes y aptitudes extraordinarias en todos los niveles y, para lo cual, se necesita de herramientas de gestion estrategicas. Una de las herramientas estrategicas constituye el sistema, basado en tecnologia informatica, que permita integrar las informaciones que requiere toda organizacion para una gestion exitosa y de calidad. Este trabajo constituye una produccion de conocimientos en el marco del desarrollo de un trabajo In Situ de analisis y diseno de un Sistema de Informacion para la Gestion de Hoteleria, en cuyo marco se desarrolla un Plan Estrategico para la Implementacion del Sistema de Gestion de Huespedes en la Empresa “Hotel Domingo Savio”. El Proyecto consistio en el diagnostico, planificacion, ejecucion y evaluacion de acciones, cuyos ejes centrales de accion fueron: lograr diferenciacion frente a otros competidores, desarrollar una herramienta de marketing y operar su negocio internamente de manera mas eficiente. Se ha logrado la produccion y aplicacion de un software a medida, patentado, que funciona bajo el sistema operativo LINUX, para la gestion de hoteleria, cuya ingenieria, desarrollada en modulos (gestion de huespedes, gestion administrativa, gestion contable y gestion de evaluacion de desempeno: con la herramienta Balanced Scorecard), se desarrollaron a partir de los procesos artesanales de la empresa de servicios de hoteleria. EnglishIn a changing context, companies need to carry out new competitions and to have a in-out cosmo vision of their organizations. This demands extraordinary attitudes and aptitudes at all levels and, for which, strategic management tools are needed. One of the strategic tools constitutes the system, based on computer technology that allows to integrate all the information required, for successful management and quality. This work constitutes a knowledge production in the framework of the development of an analysis work In Situ and the design of an Information System for Management in the industry, in whose framework, a Strategic Plan is developed for the Implementation of the Guests Management System in the, Hotel Domingo Savio, enterprise. The Project consisted in the diagnoses, planning, execution and evaluation of actions whose central action axes were: to achieve differentiation as to other competitors, to develop a framework tool and to operate one's business, internally in a more efficient way. The production and application of tailor-made software, has been achieved and patented, that works under LINUX operating system. It is for the hotel management industry, whose engineering, developed in modules (guests' management, administrative management, accounting management and performance management evaluation: with the tool Balanced Scorecard), they were developed as from the hotel industry primitive service processes.
Photosynthetic CO2-Fixation Pathways (1970)

The view has long been held that the Calvin cycle operates ubiquitously in higher plants, algae, and probably photoautotrophic bacteria, but there is now evidence for alternative pathways in some plants and bacteria. In the present article, particular emphasis will be placed upon the alternative pro­ cess in higher plants, but some aspects of current interest concerning the op­ eration of the Calvin cycle will also be considered. Topics relating to photo­ synthetic CO2-fixation that are treated in detail in other chapters of this volume have been either excluded or dealt with only briefly. There have been several recent reviews, books, and symposia dealing with aspects of photosynthetic CO2-fixation (8, SO, 55, 63, 100, 125, 128).
Inefficacy of Platelet Transfusion to Reverse Ticagrelor (2015)

The way to reverse platelet dysfunction in the context of the use of antiplatelet medications, such as ticagrelor, remains an open question. In this case, platelet transfusions were ineffectual.
Hardware-efficient debanding and visual enhancement filter for inverse tone mapped high dynamic range images and videos (2016)

If a low dynamic range (LDR) image or video is inverse tone mapped to a higher dynamic range, there can be banding artifacts in the output high dynamic range (HDR) image or video. We design a selective sparse filter to remove the banding artifacts and at the same time preserve edges and details. The filter is able to reduce other artifacts, such as blocky artifacts which are due to the compression of the LDR image/video. The filter is computationally efficient.
Review on recent advances in the field of amorphous-metal sensors and transducers (1984)

Recent researches and developments of applications of amorphous ribbons and wires to sensors and transducers are reviewed. Various sensitive and quick response magnetic sensors with very small amorphous cores have been developed corresponding to strong demands in the fields of information devices, automobiles, power motor drives, industrial robots, and industrial measurement instruments. Relationship between amorphous material properties and the suitable applications to sensors and transducers, the basic principle of amorphous sensor constitutions, and the advantageous points of amorphous sensors are represented.
View synthesis based on Conditional Random Fields and graph cuts (2010)

We propose a novel method to synthesize intermediate views from two stereo images and disparity maps that is robust to errors in disparity maps. The proposed method computes a placement matrix from each disparity map that can be used to correct errors when warping pixels from reference view to virtual view. The second contribution is a new hole filling method that uses depth, edge, and segmentation information to aid the process of filling disoccluded pixels. The proposed method selects pixels from segmented regions that are connected to the disoccluded region as candidates to fill the disoccluded pixels. We also provide an explicit probabilistic model to select the best candidate for each disoccluded pixel efficiently with Conditional Random Fields (CRFs) and graph-cuts.
Platinum agents in the treatment of osteosarcoma: Efficacy of cisplatin vs. carboplatin in human osteosarcoma cell lines (2002)

Our findings suggest that CBDCA at a two- to four-fold higher concentration than cDDP has potential therapeutic activity in platinum sensitive osteosarcomas, particularly when cDDP cytotoxicity compromises therapeutic efficacy.
Calibration and orientation of airborne image and laser scanner data using GPS and INS (2000)

GPS and INS measurements provide positions and attitudesthat can be used for direct orientation of airborne sensors.This research improves the final results by performingsimultaneous adjustments of GPS, INS and image or laser scannerdata. The first part of this thesis deals with in-airinitialisation of INS attitude using GPS and INS velocitydifference. This is an improvement over initialisation on theground. Even better results can probably be obtained ifaccelerometer biases are modelled and horizontal accelerationsmade larger. The second part of this thesis deals with GPS/INSorientation of aerial images. Theoretical investigations havebeen made to find the expected accuracy of stereo models andorthophotos oriented by GPS/INS. Direct orientation will becompared to block triangulation. Triangulation can to greaterextent model systematic errors in image and GPS-coordinates.Further, the precision in attitude after triangulation isbetter than that found in present INS performance. On the otherhand, direct orientation can provide more effective dataprocessing, since there is no need for finding or measuring tiepoints or ground control points. In strip triangulation, thenumber of ground control points can be reduced, since INSattitude measurements control error propagation through thestrip. Even if consecutive images are strongly correlated indirect orientation, it is advisable to make a relativeorientation to minimise stereo model deformations. The third part of this thesis deals with matching laserscanner data. Both elevation and intensity data are used formatching and the differences between overlapping strips aremodelled as exterior orientation errors. Special attention ispaid to determining misalignment between the INS and the laserscanner coordinate systems. We recommend flying in fourdifferent directions over an area with elevation and/orintensity gradients. In this way, misalignment can be foundwithout any ground control. This method can also be used withother imaging sensors,e.g.an aerial camera. <b>Keywords:</b>Airborne, Camera, Laser scanner, GPS, INS,Adjustment, Matching.
Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a). (1992)

Lipoprotein(a) (Lp(a)) is an atherosclerosis-causing lipoprotein that circulates in human plasma as a complex of low density lipoprotein (LDL) and apolipoprotein(a) (apo(a)). It is not known whether apo(a) attaches to LDL within hepatocytes prior to secretion or in plasma subsequent to secretion. Here we describe the development of a line of mice expressing the human apo(a) transgene under the control of the murine transferrin promoter. The apo(a) was secreted into the plasma, but circulated free of lipoproteins. When human (h)-LDL was injected intravenously, the circulating apo(a) rapidly associated with the lipoproteins, as determined by nondenaturing gel electrophoresis. Human HDL and mouse LDL had no such effect. When h-VLDL was injected, there was a delayed association of apo(a) with the lipoprotein fraction which suggests that apo(a) preferentially associated with a metabolic product of VLDL. The complex of apo(a) with LDL formed both in vivo and in vitro was resistant to boiling in the presence of detergents and denaturants, but was resolved upon disulfide reduction. These studies suggest that apo(a) fails to associate with mouse lipoproteins due to structural differences between human and mouse LDL, and that Lp(a) formation can occur in plasma through the association of apo(a) with circulating LDL.
Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat. (1991)

Antibodies specific for the insulin-regulatable glucose transporter (GLUT 4) were used to immunolocalize this protein in brown adipose tissue from basal- and insulin-treated rats. Cryosections of fixed tissue were incubated with antibodies, which were subsequently labeled with Protein A/gold and examined by EM. Antibodies against albumin and cathepsin D were also used with gold particles of different sizes to identify early and late endosomes, respectively. Under basal conditions 99% of the GLUT 4 labeling was located within the cell. Labeling was predominantly in the trans-Golgi reticulum and tubulo-vesicular structures elsewhere in the cytoplasm. In insulin-stimulated cells approximately 40% of the GLUT 4 labeling was at the cell surface, where it was randomly distributed, except for occasional clustering in coated pits. Moreover, after insulin treatment, GLUT 4 was also enriched in early endosomes. We conclude that translocation of GLUT 4 to the cell surface is the major mechanism by which insulin increases glucose transport. In addition, these results suggest that in the presence of insulin GLUT 4 recycles from the cell surface, probably via the coated pit-endosome pathway that has been characterized for cell surface receptors, and also that insulin causes the redistribution of GLUT 4 by stimulating exocytosis from GLUT 4-containing tubulo-vesicular structures, rather than by slowing endocytosis of GLUT 4.
Comparing the impact of an acute exercise bout on plasma amino acid composition, intraerythrocytic Ca2+ handling, and red cell function in athletes and untrained subjects (2016)

The N-methyl d-aspartate receptors (NMDARs) mediating Ca(2+) uptake upon stimulation with glutamate and glycine were recently discovered in red blood cells (RBC) of healthy humans. Activation of these receptors with agonists triggered transient Ca(2+)-dependent decrease in hemoglobin oxygen affinity in RBC suspension. The aim of this study was to assess the potential physiological relevance of this phenomenon. Two groups formed by either healthy untrained volunteers or endurance athletes were subjected to a stepwise incremental cycling test to exhaustion. Plasma glutamate levels, activity of the NMDARs, and hemoglobin O2 affinity were measured in blood samples obtained before and after the exercise in both groups. Increase in plasma glutamate levels following exercise was observed in both groups. Transient Ca(2+) accumulation in response to the NMDAR stimulation with NMDA and glycine was followed by facilitated Ca(2+) extrusion from the RBC and compensatory decrease in cytosolic Ca(2+) levels. Short-term activation of the receptors triggered a transient decrease in O2 affinity of hemoglobin in both groups. These exercise-induced responses were more pronounced in athletes compared to the untrained subjects. Athletes were initially presented with lower basal intracellular Ca(2+) levels and hemoglobin oxygen affinity compared to non-trained controls. High basal plasma glutamate levels were associated with induction of hemolysis and formation of echinocytes upon stimulation with the receptor agonists. These findings suggest that glutamate release occurring during exhaustive exercise bouts may acutely facilitate O2 liberation from hemoglobin and improve oxygen delivery to the exercising muscle.
Anatomy of Normal Human Anterior Cruciate Ligament Attachments Evaluated by Divided Small Bundles (2009)

The results of this study of the normal ACL will provide insights for surgeons when placing grafts during anatomic ACL reconstruction.
Method for monitoring allergies (1974)

Journal Article Method for monitoring allergies Get access G. A. Stock, Jr G. A. Stock, Jr Director of Pharmacy Doctors Hospital Inc. of Stark County, 400 Austin Ave., N.W., Massillon, Ohio 44646 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 31, Issue 9, 1 September 1974, Page 824, https://doi.org/10.1093/ajhp/31.9.824 Published: 01 September 1974
The role of prostaglandins in the bronchoconstriction induced by pulmonary micro‐embolism in the guinea‐pig. (1980)

1. Respiratory resistance was measured by a forced oscillation technique in vagotomized guinea-pigs before and after pulmonary micro-embolism produced by I.V. injection of 0.5 ml./kg of 10% w/v BaSO4. Changes in quasi-static inspiratory compliance and arterial platelet count were also measured. 2. Micro-embolic challenge with BaSO4 increased respiratory resistance by 27%; this was abolished by prior treatment with indomethacin; no change in the control resistance occurred after indomethacin. 3. No change in respiratory compliance or arterial platelet numbers were observed following low dose BaSO4 micro-embolism. This suggests that pulmonary micro-embolism produced a decrease in medium or large airway calibre, which was mediated by a prostaglandin-like substance from lung tissue, and did not require the presence of the vagus nerves.
Effect of protein dynamics on biological electron transfer (1997)

Computer simulations of the effect of protein dynamics on the long distance tunneling mediated by the protein matrix have been carried out for a Ru-modified (His 126) azurin molecule. We find that the tunneling matrix element is a sensitive function of the atomic configuration of the part of the protein matrix in which tunneling currents (pathways) are localized. Molecular dynamics simulations show that fluctuations of the matrix element can occur on a time scale as short as 10 fs. These short time fluctuations are an indication of a strong dynamic coupling of a tunneling electron to vibrational motions of the protein nuclear coordinates. The latter results in a modification of the conventional Marcus picture of electron transfer in proteins. The new element in the modified theory is that the tunneling electron is capable of emitting or absorbing vibrational energy (phonons) from the medium. As a result, some biological reactions may occur in an activationless fashion. An analytical theoretical model is proposed to account for thermal fluctuations of the medium in long distance electron transfer reactions. The model shows that, at long distances, the phonon-modified inelastic tunneling always dominates over the conventional elastic tunneling.
Common Signaling Themes (2004)

Contents Viewpoints Common and Distinct Elements in Cellular Signaling via EGF and FGF Receptors J. Schlessinger Pheromone Signaling Mechanisms in Yeast: A Prototypical Sex Machine Y. Wang and H. G. Dohlman Jekyll and Hyde in the Microbial World D. M. Truckses, L. S. Garrenton, J. Thorner When the Stress of Your Environment Makes You Go HOG Wild P. J. Westfall, D. R. Ballon, J. Thorner The Ethylene Signaling Pathway J. M. Alonso and A. N. Stepanova Keeping the Leaves Green Above Us A. Gfeller and E. E. Farmer Natural Killer Cell Signaling Pathways E. Vivier, J. A. Nunès, F. Vély See related Editorial and links to relevant signaling pathways
Effects of energy transfer among Er^3+ ions on the fluorescence decay and lasing properties of heavily doped Er:Y_3Al_5O_12 (1990)

Nonexponential fluorescence decay has been observed from both 4I11/2 and 4I13/2 states of Er3+ ions in heavily doped Er: YAG at room temperature. Processes of cross relaxation that originate in these states are shown to be responsible. Rate equations that include cross-relaxation processes are written and numerically solved, to result in the determination of the cross-relaxation coefficients. It is found that these coefficients do not change with Er3+ concentration. The effects of the cross-relaxation processes of Er3+ ions on fluorescence decay and lasing properties are discussed.
BRITISH COST ACCOUNTING DEVELOPMENT: CONTINUITY AND CHANGE (1995)

This paper uses the archival records of three entities successively carrying on coal and ironmaking activities at Staveley between 1838–1900, together with the findings from earlier research, to explore the costing information generated over the period 1690–1900. We find a system of cost accounting, broadly defined, in operation throughout the period, a large measure of continuity concerning its basic features, and innovations made from time to time presumably designed to improve its usefulness. The paper uses the results of this and earlier research to explore the nature of accounting change and draws attention to possible differences in the path of development between countries. Further, we assess the significance of our findings for present ideas concerning the development of cost accounting systems in Britain and the U.S., and argue for a broader view to be taken by researchers into the nature of management accounting's development.
Interferon-γ release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis (2010)

Interferon-γ release assays (IGRAs) are now established for the immunodiagnosis of latent infection with Mycobacterium tuberculosis in many countries. However, the role of IGRAs for the diagnosis of active tuberculosis (TB) remains unclear. Following preferred reporting items for systematic reviews and meta-analyses (PRISMA) and quality assessment of diagnostic accuracy studies (QUADAS) guidelines, we searched PubMed, EMBASE and Cochrane databases to identify studies published in January 2001-November 2009 that evaluated the evidence of using QuantiFERON-TB® Gold in-tube (QFT-G-IT) and T-SPOT.TB® directly on blood or extrasanguinous specimens for the diagnosis of active TB. The literature search yielded 844 studies and 27 met the inclusion criteria. In blood and extrasanguinous fluids, the pooled sensitivity for the diagnosis of active TB was 80% (95% CI 75-84%) and 48% (95% CI 39-58%) for QFT-G-IT, and 81% (95% CI 78-84%) and 88% (confirmed and unconfirmed cases) (95% CI 82-92%) for T-SPOT.TB®, respectively. In blood and extrasanguinous fluids, the pooled specificity was 79% (95% CI 75-82%) and 82% (95% CI 70-91%) for QFT-G-IT, and 59% (95% CI 56-62%) and 82% (95% CI 78-86%) for T-SPOT.TB®, respectively. Although the diagnostic sensitivities of both IGRAs were higher than that of tuberculin skin tests, it was still not high enough to use as a rule out test for TB. Positive evidence for the use of IGRAs in compartments other than blood will require more independent and carefully designed prospective studies.