gebhart/patrepeval huggingface dataset:
Stability of <i>Trans</i> ‐Resveratrol Encapsulated in a Protein Matrix Produced Using Spray Drying to UV Light Stress and Simulated Gastro‐Intestinal Digestion (2015)

Trans-resveratrol has demonstrated the potential to provide both therapeutic and preventive activities against chronic diseases such as heart disease and cancer. The incorporation of trans-resveratrol into food products would allow for broader access of this bioactive compound to a larger population. However, this strategy is limited by instability of trans-resveratrol under environmental conditions and within the digestive system leading to isomerization of trans-resveratrol (bioactive form) to cis-resveratrol (bio-inactive form). Studies in the stabilization of trans-resveratrol into protein microparticles are presented. Trans-resveratrol was encapsulated using whey protein concentrate (WPC) or sodium caseinate (SC), with or without anhydrous milk fat (AMF). Binding of resveratrol and aromatic residues in protein was estimated utilizing the Stern-Volmer equation and the number of tryptophan residues. The stability of encapsulated resveratrol was evaluated after exposure to ultraviolet A (UVA) light and 3-stage in vitro digestion. After UVA light exposure, SC-based microcapsules maintained a higher trans:cis resveratrol ratio (0.63, P < 0.05) than WPC-based microcapsules (0.43) and unencapsulated resveratrol (0.49). In addition, encapsulation of resveratrol in both protein microparticles led to an increased digestive stability and bioaccessibility in comparison to unencapsulated resveratrol (47% and 23%, respectively, P < 0.05). SC-based microcapsules provided a higher digestive stability and bioaccessibility (86% and 81%; P < 0.05) compared to WPC-based microcapsules (71% and 68%). The addition of AMF to the microcapsules did not significantly change the in vitro digestion values. In conclusion, SC-based microencapsulation increased the stability of trans-resveratrol to UVA light exposure and simulated digestion conditions. This encapsulation-system-approach can be extended to other labile, bioactive polyphenols.
Clinical, biochemical, and molecular analysis of combined methylmalonic acidemia and hyperhomocysteinemia (cblC type) in China (2010)

The most common inborn error of cobalamin (cbl) metabolism in China is the cblC type characterized by combined methylmalonic acidemia and hyperhomocysteinemia. The clinical presentation is relatively nonspecific, such as feeding difficulty, recurrent vomiting, hypotonia, lethargy, seizures, progressive developmental delay, and mental retardation, together with anemia and metabolic acidosis. More specific biochemical findings include high levels of propionylcarnitine (C3), free carnitine (C3/C0), and acetylcarnitine (C3/C2) measured by tandem mass spectrometry (MS/MS), elevation of methylmalonic acid (MMA) measured by gas chromatography-mass spectrometry (GC-MS), and increased total homocysteine with normal or decreased methionine. We report on 50 Chinese patients with combined methylmalonic acidemia and hyperhomocysteinemia. Forty-six belonged to the cblC complementation group. Mutation analysis of the MMACHC gene was performed to characterize the mutational spectrum of cblC deficiency, and 17 different mutations were found. Most were clustered in exons 3 and 4, accounting for 91.3% of all mutant alleles. Two mutations were novel, namely, c.315 C>G (p.Y105X) and c.470 G>C(p.W157S). In terms of genotype-phenotype correlation, the c.609 G>A mutation was associated with early-onset disease when homozygous. Unlike previous reports from other populations, c.609 G>A (p.W203X) was the most frequent cblC mutation detected in our study of Chinese patients, affecting 51 of 92 MMACHC alleles (55.4%). The high prevalence of this nonsense mutation could have potential therapeutic significance for Chinese cblC patients. Besides traditional approaches consisting of hydroxocobalamin injections, carnitine, betaine, and protein restriction, novel drugs that target premature termination codons may have a role in the future.
An Analytic Tool for Prediction of Hemodynamic Responses to Vasopressors (2013)

This paper presents a new analytic tool for automated control of vasopressor infusion, which uses measured changes in blood pressure to infer changes in the underlying cardiovascular system and then estimate dose-response relationships for the underlying cardinal cardiovascular parameters, i.e., those related to cardiac output (CO) and total peripheral resistance (TPR). Ultimately, blood pressure as a function of vasopressor dose is predicted based on the estimated underlying cardiovascular state by extrapolating the dose-response relationship. As well, this tool adapts to individual subjects with a minimum of individualized training data. In this report, proof-of-principle is provided using experimental epinephrine dose-response data from four different sets of subjects. Given two observations from different infusion rates, the analytic tool was able to accurately predict the groups' blood pressure, heart rate, TPR, stroke volume, and CO as a function of vasopressor dose levels: the root-mean-squared prediction error for the mean arterial pressure (MAP) was consistently smaller than 5% of the underlying MAP; the r(2) values for the TPR, stroke volume, and CO were consistently higher than 0.96; and the limits of agreement between actual versus predicted blood pressure (BP), TPR, stroke volume, and CO were consistently smaller than 8% of the respective underlying values. The proposed analytic tool may provide a meaningful step towards automated control of vasopressor therapy.
Antimalarial agents. 8. Ring-substituted bis(4-aminophenyl) sulfones and their precursors (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntimalarial agents. 8. Ring-substituted bis(4-aminophenyl) sulfones and their precursorsIvan C. Popoff, Allan R. Engle, Reginald L. Whitaker, and Gopal H. SinghalCite this: J. Med. Chem. 1971, 14, 12, 1166–1169Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/jm00294a006https://doi.org/10.1021/jm00294a006research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New DArT markers for oat provide enhanced map coverage and global germplasm characterization (2009)

These markers will provide a solid basis for future efforts in genomic discovery, comparative mapping, and the generation of an oat consensus map. They will also provide new opportunities for directed breeding of superior oat varieties, and guidance in the maintenance of oat genetic diversity.
Nonpolar Nonvolatile Resistive Switching in Cu Doped $\hbox{ZrO}_{2}$ (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In this letter, the unique reproducible nonpolar resistive switching behavior is reported in the Cu-doped <formula formulatype="inline"><tex>$\hbox{ZrO}_{2}$</tex> </formula> memory devices. The devices are with the sandwiched structure of Cu/<formula formulatype="inline"><tex>$\hbox{ZrO}_{2}$</tex></formula>:Cu/Pt. The switching between high resistance state (<emphasis emphasistype="smcaps">off</emphasis>-state) and low resistance state ( <emphasis emphasistype="smcaps">on</emphasis>-state) does not depend on the polarity of the applied voltage bias and can be achieved under both voltage sweeping and voltage pulse. The ratio between the high and low resistance is on the order of <formula formulatype="inline"><tex>$\hbox{10}^{6}$</tex> </formula>. Set and Reset operation in voltage pulse mode can be as fast as 50 and 100 ns, respectively. No data loss is found upon continuous readout for more than <formula formulatype="inline"><tex>$\hbox{10}^{4}\ \hbox{s}$</tex> </formula>. Multilevel storage is considered feasible due to the dependence of <emphasis emphasistype="smcaps">on</emphasis>-state resistance on Set compliance current. The switching mechanism is believed to be related with the formation and rupture of conducting filamentary paths. </para>
Handbook of Biosensors and Electronic Noses: Medicine, Food, and the Environment (1996)

From the Publisher:
In developing the electronic nose and biosensor devices,researchers not only copy biochemical pathways, but also use nature's approach to signal interpretation as a blueprint for man-made sensing systems. Commercial biosensors have demonstrated their benefits and practical applications, providing high sensitivity and selectivity, combined with a significant reduction in sample preparation assay time and the use of expensive reagents.
The Handbook of Biosensors and Electronic Noses discusses design and optimization for the multitude of practical uses of these devices including:
An Agile Multi-Node Multi-Antenna Wireless Channel Sounding System (2019)

The upcoming fifth-generation wireless technology application areas bring new communication performance requirements, mainly in terms of reliability and latency, but also in terms of radio planning, where the further detailed characterization of the wireless channel is needed. To address these demands, we developed an agile multi-node multi-antenna wireless channel sounding system, using multiple software-defined radio devices. The system consists of 12 testbed nodes which are controlled from a centralized testbed server. Each node features a control host computer and two multi-antenna universal software radio peripheral boards. By managing the transmission and reception of reference signals among all the distributed testbed nodes, the system can measure the channel conditions of all multiple independent radio links. At the same time, the distributed architecture of the testbed allows a large number of spatially distributed locations to be covered with only a few redeployments of the testbed nodes. As a consequence of this, the system favors the collection of a large number of distributed channel samples with limited effort within a short dedicated measurement time. In this paper, we detail the general testbed design considerations, along with the specific sounding signal processing implementations. As further support to the system design, we also include the results from different verification and calibration tests, as well as a real measurement application example.
Identification of a New Natural Ara h 6 Isoform and of Its Proteolytic Product as Major Allergens in Peanut (2007)

Numerous food allergens of plant origin belong to the 2S albumin family, including peanut Ara h 2. In addition to Ara h 2, several other conglutins related to 2S albumins are present in peanut seeds. We evaluated the allergenicity of different peanut conglutins as compared with Ara h 2. Several conglutins were isolated from the kernel, i.e. Ara h 2, a new isoform of Ara h 6 and its derived product, which is likely to be naturally formed during seed processing. Enzyme allergosorbent tests performed on sera of peanut allergic patients showed that more than 94% of 47 analyzed patients had positive IgE responses to Ara h 6 isoform and to its degradation product. Skin prick tests with the new isoform of Ara h 6 led to a positive response in seven out of the eight tested patients. Both enzyme allergosorbent tests and skin prick tests showed that the reactivity of Ara h 6 was similar to, or even higher than, that of Ara h 2, suggesting that the present isoform of Ara h 6 is as allergenic as Ara h 2. In addition the IgE response to the plant processed (i.e., hydrolyzed) Ara h 6 new isoform is equivalent to the IgE response to the native isoform. The IgE immunoreactivity is mostly abrogated by chemical reduction and denaturation of Ara h 6 isoforms, which underlined the importance of tertiary structure in Ara h 6 immunoreactivity. These results, and particularly the high correlation between anti-Ara h 2 and anti-Ara h 6 IgE responses, emphasise the major role of 2S albumins in peanut allergenicity.
Wasserstoff (1918)

Zeichen H, von Hydrogenium = Wasserbildner, Atomgewicht 1,008, Schmelzpunkt −258°, Siedepunkt −252,5°, kritische Temperatur −241°, kritischer Druck 20 Atmosphären. Spezifisches Gewicht des flüssigen Wasserstoffs = 0,07 beim Siedepunkt, Gewicht von 1 l Wasserstoffgas bei 0° und 760 min Druck = 0,08995 g, welche Menge man ein Krith nennt.
Synthesis of 6,6'-diethynyldiphenic anhydride (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 6,6'-diethynyldiphenic anhydrideMelvin S. Newman and Marshall W. LogueCite this: J. Org. Chem. 1971, 36, 10, 1398–1401Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1 May 1971https://pubs.acs.org/doi/10.1021/jo00809a018https://doi.org/10.1021/jo00809a018research-articleACS PublicationsRequest reuse permissionsArticle Views483Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plasma ubiquitin–proteasome system profile in patients with multiple sclerosis: correlation with clinical features, neuroimaging, and treatment with interferon-beta-1b (2012)

Since UPS is linked to protein degradation, it may contribute to the course of immune-mediated diseases such as MS, and pharmacologic inhibition of UPS through IFN-beta-1b therapy improves the clinical course of MS. Larger clinical trials are needed to confirm the results of this preliminary study.
Joint 3D Proposal Generation and Object Detection from View Aggregation (2018)

We present AVOD, an Aggregate View Object Detection network for autonomous driving scenarios. The proposed neural network architecture uses LIDAR point clouds and RGB images to generate features that are shared by two subnetworks: a region proposal network (RPN) and a second stage detector network. The proposed RPN uses a novel architecture capable of performing multimodal feature fusion on high resolution feature maps to generate reliable 3D object proposals for multiple object classes in road scenes. Using these proposals, the second stage detection network performs accurate oriented 3D bounding box regression and category classification to predict the extents, orientation, and classification of objects in 3D space. Our proposed architecture is shown to produce state of the art results on the KITTI 3D object detection benchmark [1] while running in real time with a low memory footprint, making it a suitable candidate for deployment on autonomous vehicles. Code is available at: https://github.com/kujason/avod.
Reflection measurement of absorption coatings using 600-670 GHz vector network analyzer (2007)

This article describes several aspects of ALMA band 9 cartridges: design, development and characterization. We give special attention to the characterization of the system. In this context, we present the noise measurements of the first eight cartridges with an emphasis on the extremely large IF bandwidth (4-12 GHz). The IF gain slope, receiver linearity and saturation, receiver beam pattern and cross polarization level measurements are also presented.
A novel method in passive localization: Synthetic Triangulation Beamformer (2011)

In this paper, a new passive localization algorithm based on beamforming techniques is proposed. The distance to the target is obtained by triangulation using a number of bearings estimated at different time periods along a track. The proposed algorithm has been evaluated on field-trial data where good range estimation performance has been shown.
The influence of co-existing anions on adsorption of phosphate by niobium hydroxide (2012)

Niobium hydroxide prepared by the hydrofluoric acid method was used as the adsorbent of phosphate.The effect of co-existing anions such as Cl-,SO2-4 and NO-3 on adsorption was investigated by using phosphate in the solution as adsorbate.The results showed that the largest adsorption capacity of phosphate by the niobium hydroxide was 43.31 mg/g when 200 mL of phosphate(50 mg/L,PH=2)was added at 25 ℃.When the concentration of three anions was 50,100,150 mg/L respectively,the adsorption capacity of different anions was in the following order:PO3-4SO2-4NO-3 Cl-,PO3-4SO2-4NO-3Cl-and PO3-4Cl-≈SO2-4NO-3,respectively.However,the adsorption capacity of PO3-4 was reduced in the presence of the co-existing anions(Cl-、SO2-4、NO-3),and the competition was formed among these anions.The phosphate adsorbed by the niobium hydroxide could be desorbed under certain conditions.25% Concentrated ammonia solution(10 mL)was added to wash away the phosphate on the surface of niobium hydroxide,washing with distilled water,the filtrate was added water to 50 mL,the desorption ratio was about 53.1%.The results of FT-IR spectra showed that the phosphate on the surface was not completely desorbed.
Activation, binding, and processing of complement component 3 (C3) by Blastomyces dermatitidis (1997)

Complement plays a key role in phagocyte recognition and killing of Blastomyces dermatitidis, but little is known about how complement components interact with the yeast. We report the characteristics of activation, binding, and processing of C3 by B. dermatitidis. In pooled normal human serum (NHS), deposition of C3 on the yeast was detectable within 2 min, whereas in NHS containing MgEGTA, deposition was delayed by 6 min, indicating that the yeast activates C3 by both classical and alternative pathways. When both pathways were operative, maximal binding of 4.5 x 10(6) C3 molecules/cell was achieved in less than 30 min. In the absence of the classical pathway, yeast cells bound 80% of the maximum C3, indicating that the yeast intrinsically activates the alternative pathway. Delayed deposition of C3 in NHS-MgEGTA was similar to that in NHS preabsorbed by the yeast or by immobilized protein A/G to remove serum immunoglobulin. Purified immunoglobulin restored C3 binding to NHS preabsorbed by the yeast, suggesting that antibody in nonimmune serum initiates the classical pathway. beta-Glucan absorption of NHS abolished the classical pathway, suggesting that cell wall beta-glucan is a target of initiating antibodies. Hydroxylamine treatment of NHS-opsonized yeast cells showed that 76% of C3 was bound to yeast cells by ester linkage, supporting a role for hydroxyl groups on cell wall polysaccharides. Hydroxylamine-cleaved fragments were chiefly C3b and iC3b; 70% of hydroxylamine-sensitive C3b was converted to iC3b within 1 min of opsonization, and the ratio was stable over 1 h. Our data predict that C3b and iC3b on opsonized yeast cells direct binding to CR1 and CR3 receptors on human phagocytes, which, in turn, may influence the fate of this host-pathogen interaction.
New tap changing scheme (1996)

Tap changers have not changed radically since their invention in the early part of this century. They are slow in operation, typically traversing 19 taps in around 100 seconds, and require frequent maintenance. Previous attempts to devise improved tap changers have concentrated upon thyristor assisted or all solid-state units. For various reasons none of these schemes has been adopted. A new GTO thyristor assisted tap changer is introduced here which addresses the problems of previous schemes. It eliminates excessive conduction losses which are inherent in solid-state tap changers, and at the same time provides a fast response speed by means of fast acting vacuum switches. Calculations show that it will be possible to traverse a 19 tap range in around 0.5 s. A unit for a 240 MVA transformer will require minimal maintenance as the vacuum switches used in the selector and diverter never make or break more than a few amperes. Test results are given for a 3 kVA transformer and tap changer unit.
Comparative Advantages of Cross-strait Aquatic Products Trade and Zhoushan Countermeasures (2010)

In the initial stage, the status quo of aquatic products industry in Taiwan and Zhoushan is analyzed. The aquatic products industry in Taiwan is characterized by high input, high output, advanced fishery import and export trade, refined and specialized fishery organizations and the dominant role played by the government. However, in Zhoushan, there are many problems in the development of aquatic products industry, featuring weak brand consciousness, inadequate famous brand and pillar industries, frequently restricted by green trade barrier and disordered competition of aquatic products market. The comparative advantages of aquatic products Cross-Straits are measured by using revealed comparative advantage index (RCA) and trade specialized index (TSC), the results show that the aquatic products in both the mainland and Taiwan have certain market share and competitiveness. The revealed comparative advantage index （RCA）of Taiwan’ aquatic products is higher than that in the mainland, while the RCA index in the mainland and Taiwan all shows descending trend; the trade specialized index(TSC) cross straits is positive, which indicates specialized export, but this specialization also shows descending trend. Taiwan has advanced aquaculture technology and the mainland owns cheap labor cost and low price, but due to the limited resources in the Taiwan Island and the backward processing technology of aquatic products in the mainland, the comparativeness of aquatic products in the mainland and Taiwan has slid slightly. Therefore, I probe into the cooperation modality between Zhoushan and Taiwan in terms of mutual investment in aquatic industry, exchange and training for personnel cross straits and establishing experimental point of aquatic industry of the Zhoushan Island and Taiwan Island. Besides, countermeasures for enhancing the international comparativeness of aquatic industry in Zhoushan Island are put forward.