gebhart/patrepeval huggingface dataset:
Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: Up-regulation of poly(A) polymerase (1997)

Tissue factor (TF) is the cellular receptor for an activated form of clotting factor VII (VIIa) and the binding of factor VII(a) to TF initiates the coagulation cascade. Sequence and structural patterns extracted from a global alignment of TF confers homology with interferon receptors of the cytokine receptor super family. Several recent studies suggested that TF could function as a genuine signal transducing receptor. However, it is unknown which biological function(s) of cells are altered upon the ligand, VIIa, binding to TF. In the present study, we examined the effect of VIIa binding to cell surface TF on cellular gene expression in fibroblasts. Differential mRNA display PCR technique was used to identify transcriptional changes in fibroblasts upon VIIa binding to TF. The display showed that VIIa binding to TF either up or down-regulated several mRNA species. The differential expression of one such transcript, VIIa-induced up-regulation, was confirmed by Northern blot analysis. Isolation of a full-length cDNA corresponding to the differentially expressed transcript revealed that VIIa-up-regulated gene was poly(A) polymerase. Northern blot analysis of various carcinomas and normal human tissues revealed an over expression of PAP in cancer tissues. Enhanced expression of PAP upon VIIa binding to tumor cell TF may potentially play an important role in tumor metastasis.
A General Stochastic Degradation Modeling Approach for Prognostics of Degrading Systems With Surviving and Uncertain Measurements (2019)

This paper is concerned with estimating remaining useful life (RUL) for a class of stochastic degrading systems with surviving degradation paths and uncertain measurements. The motivation comes from two engineering facts: the system's degradation state is discretely monitored and the measured degradation signals are taken from a survival degradation path, i.e., its lifetime is greater than the latest observation time, and the underlying degradation state cannot be perfectly observed due to the noise, disturbance, nonideal instruments, etc. Thus, the measured degradation signals are uncertain, but related to the underlying degradation state. Toward this end, we first present a general stochastic degradation modeling approach to account for the abovementioned facts. Then, a non-Gaussian degradation state transition equation is derived considering the constraint of the survival path and thus the particle filtering algorithm is used to estimate the underlying degradation state in real time from uncertain measurements. Furthermore, we derive the RUL distribution based on the first-passage time concept which incorporates the uncertainty of the estimation for the degradation state and can be real-time updated based on the available surviving yet uncertain measurements. The novelty of this paper is to allow us to exclude the probability of failure between discrete monitoring times and to account for the impacts of surviving and uncertain measurements on estimating both the degradation state and the RUL. To apply the presented methodology, a maximum likelihood estimation framework is provided to determine the model parameters based on the expectation maximization algorithm together with particle filtering and smoothing methods. As a special case fallen into the presented framework, a linear degradation modeling and prognostic realization is discussed. Finally, we demonstrate the proposed approach by a case study.
Synthesis of Medical Adhesives from Segmented Poly(urethane)s. (1992)

常温で液状であるポリプロピレングリコール及びエチレンオキシドとプロピレンオキシドとのABA型ブロック共重合体あるいはランダム共重合体をセグメントに, ポリエチレングリコールモノメチルエーテル (M-PEG) をその分岐鎖としてもつセグメント化ポリエーテルウレタンを合成した. ポリオール成分とイソシアネート成分の組み合わせ, OH/NCO比及びM-PEGのポリオール成分に対する比率を変えることによって広範囲の初期粘着力をもつ粘着性ゲルが得られた. M-PEGはタック付与剤として作用した. タックカの最大値は800g (対ステンレスSUS #304面, 剥離速度1000 mm/min) であった.
High-power double-clad Yb-doped fiber laser (2002)

We present an experimental study of the Yb-doped double-clad fiber laser operating in the 1.08 micrometers wavelength. The fiber side-pumped with a high power laser diode using the v- groove technique. Various experimental configurations are performed from the linear cavity to an all-fiber tunable unidirectional ring cavity. Mode-locking of the Yb laser are investigated using the nonlinear polarization rotation.
Characterization of Si/Si1−<i>y</i>C<i>y</i> superlattices grown by surfactant assisted molecular beam epitaxy (1996)

Si/Si0.97C0.03 superlattices grown on Si(001) substrates by Sb surfactant assisted molecular beam epitaxy are characterized by in situ reflection high energy electron diffraction (RHEED), atomic force microscopy, transmission electron microscopy (TEM), and high resolution x-ray diffraction. The RHEED shows that, in the absence of Sb, the growth front roughens during Si0.97C0.03 growth and smooths during subsequent Si growth. In contrast, when Sb is present, the growth front remains smooth throughout the growth. This observation is confirmed by cross-sectional TEM, which reveals that for samples grown without the use of Sb, the Si/Si0.97C0.03 interfaces (Si0.97C0.03 on Si) are much more abrupt than the Si0.97C0.03/Si interfaces. In the case of Sb assisted growth, there is no observable difference in abruptness between the two types of interfaces. Atomic force microscopy micrographs of the Si0.97C0.03 surface reveal features that could be the source of the roughness observed by RHEED and TEM.
Approaches of targeting Rho GTPases in cancer drug discovery (2015)

To date, while no clinically effective drugs targeting Rho GTPase signaling for cancer treatment are available, tool compounds and lead drugs that pharmacologically inhibit Rho GTPase pathways have shown promise. Small-molecule inhibitors targeting Rho GTPase signaling may add new treatment options for future precision cancer therapy, particularly in combination with other anti-cancer agents.
A°land Island Eye Disease (Forsius-Eriksson Syndrome) Associated With Contiguous Deletion Syndrome at Xp21 (1989)

We report the ophthalmological findings of a 6-year-old boy who has features of both Aland Island eye disease (also called Forsius-Eriksson ocular albinism) and incomplete congenital stationary night blindness, as defined by Miyake, leading us to suspect that they are the same entity. This child has a deletion of part of band 21 of the short arm of the X chromosome (Xp21) and three other X-linked disorders: congenital adrenal hypoplasia, glycerol kinase deficiency, and Duchenne type muscular dystrophy. The electroretinogram showed negative scotopic and abnormal photopic waveforms that were similar, if not identical, to the electroretinographic findings in both Aland Island eye disease and X-linked incomplete congenital stationary night blindness. Because of this similarity and the defective dark adaptometry that has been reported in patients with this disorder, we believe that Aland Island eye disease is more appropriately classified as a form of congenital night blindness than as a form of ocular albinism. From our case and review of the literature, Aland Island eye disease and incomplete congenital stationary night blindness appear indistinguishable. If further studies confirm that the disorders are the same, we recommend use of the term Aland Island eye disease or Forsius-Eriksson-Miyake syndrome. We also recommend that the gene symbols CSNB1 and CSNB2 be used for complete congenital stationary night blindness and Aland disease, respectively.
Physical Proximity and Online User Behaviour in an Indoor Mobile Social Networking Application (2011)

This paper studies the encounter patterns and online connections of 76 users in an indoor location sharing and online interaction social network application, to seek underlying relationship between users' offline behaviors and online social behaviors. We create an indoor location and proximity-based mobile social network system called Find & Connect that collects and records current indoor location of users and then enables users to generate and maintain their online social relationships. We obtain quantitative data which presents properties of users' online behaviors and offline behaviors, and then perform a user study to verify the utility of Find & Connect applied in large meeting events. Using quantified parameters, particularly, encounters regarded as representation of offline behaviors, and exchange contacts and follow as main kinds of online behaviors, our study shows a positive effect by offline behaviors on online social behavior, while a negative effect by online social connection establishing on afterwards offline social interaction. We also find that according to different kinds of online behaviors, their correlation with offline interaction resembles but has diversity in intensity.
An Overview of Iterative Coupling Between Geomechanical Deformation and Reservoir Flow (2005)

ABSTRACT Recently, there is a strong interest in the modelling of reservoir fluid flow with geomechanical deformation. With the help of geomechanics, many physical phenomena can be explained, e.g. reservoir compaction and subsidence, casing failure or pore collapse. Several methods for coupling geomechanics to fluid flow in the reservoir have been proposed: fully coupled, iterative coupled and explicit coupled methods. The iterative coupled method has proven to be the most effective approach. However, no paper has discussed this method in detail from a reservoir engineering perspective. In this paper, the iterative coupling method is described step by step from the basic equations for geomechanics and reservoir flow to the coupling technique through porosity and permeability. This description is aimed at reservoir engineers with little background in geomechanics. A number of examples using different nonlinear constitutive models such as elasto-plasticity model, elastoplastic cap model and dilation-recompaction model are used to illustrate the importance of including geomechanics in reservoir simulation.
Treatment for sulfur mustard lung injuries; new therapeutic approaches from acute to chronic phase (2012)

Complementary studies on one hand regarding pharmacokinetic of drugs and molecular investigations are mandatory to obtain more effective treatments.
A NSGA-II based approach for camera placement problem in large scale surveillance application (2012)

Camera placement has huge impact on the performance of large scale surveillance. The quality of the coverage and cost of the camera network make the problem multi-objective. The problem becomes even more difficult when realistic conditions like obstacles, preference coverage and resolution are considered. In this work we propose a framework for optimal camera placement, giving simultaneous consideration to different qualitative aspects using multi-objective genetic algorithm (NSGA-II). We improve our camera-coverage model by including the realistic parameters such as frontal coverage and the optimal range of view of a camera. We develop a novel camera coverage calculation algorithm which ensures that the proposed set-up is applicable to surveillance tasks such as face recognition and object tracking. Developed algorithm has been tested on realistic floor plans and optimal lay-outs have been reported.
Purification, cDNA Cloning, and Regulation of Lysophospholipase from Rat Liver (1996)

A lysophospholipase was purified 506-fold from rat liver supernatant. The preparation gave a single 24-kDa protein band on SDS-polyacrylamide gel electrophoresis. The enzyme hydrolyzed lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylinositol, lysophosphatidylserine, and 1-oleoyl-2-acetyl-sn-glycero-3-phosphocholine at pH 6-8. The purified enzyme was used for the preparation of antibody and peptide sequencing. A cDNA clone was isolated by screening a rat liver lambda gt11 cDNA library with the antibody, followed by the selection of further extended clones from a lambda gt10 library. The isolated cDNA was 2,362 base pairs in length and contained an open reading frame encoding 230 amino acids with a Mr of 24,708. The peptide sequences determined were found in the reading frame. When the cDNA was expressed in Escherichia coli cells as the beta-galactosidase fusion, lysophosphatidylcholine-hydrolyzing activity was markedly increased. The deduced amino acid sequence showed significant similarity to Pseudomonas fluorescence esterase A and Spirulina platensis esterase. The three sequences contained the GXSXG consensus at similar positions. The transcript was found in various tissues with the following order of abundance: spleen, heart, kidney, brain, lung, stomach, and testis = liver. In contrast, the enzyme protein was abundant in the following order: testis, liver, kidney, heart, stomach, lung, brain, and spleen. Thus the mRNA abundance disagreed with the level of the enzyme protein in liver, testis, and spleen. When HL-60 cells were induced to differentiate into granulocytes with dimethyl sulfoxide, the 24-kDa lysophospholipase protein increased significantly, but the mRNA abundance remained essentially unchanged. Thus a posttranscriptional control mechanism is present for the regulation of 24-kDa lysophospholipase.
The blood-brain barrier and cerebrospinal fluid, in relation to the efficacy of sleeping-sickness drugs (1943)

E. M. Lourie, Trans. Faraday Soc., 1943, 39, 340 DOI: 10.1039/TF9433900340
Theory of the Atomic and Electronic Structure of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>DX</mml:mi></mml:math>Centers in GaAs and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Al</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Ga</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mo>−</mml:mo><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mi mathvariant="normal">As</mml:mi></mml:math>Alloys (1988)

We propose that $\mathrm{DX}$ is a negatively charged defect center resulting from the "reaction" $2{d}^{0}\ensuremath{\rightarrow}{d}^{+}+D{X}^{\ensuremath{-}}$ where $d$ represents a substitutional donor. The results of our pseudopotential calculations for Si- and S-induced $\mathrm{DX}$ centers in GaAs indicate large dopant-dependent relaxations leading to threefold-coordinated interstitial sites for either the donor or one of its nearest neighbors. A simple expression for the alloy composition and pressure dependence of the $\mathrm{DX}$ binding energy is suggested and used in an analysis of experimental data.
Trust-Region Algorithms for Training Responses: Machine Learning Methods Using Indefinite Hessian Approximations (2018)

Machine learning (ML) problems are often posed as highly nonlinear and nonconvex unconstrained optimization problems. Methods for solving ML problems based on stochastic gradient descent are easily scaled for very large problems but may involve fine-tuning many hyper-parameters. Quasi-Newton approaches based on the limited-memory Broyden-Fletcher-Goldfarb-Shanno (BFGS) update typically do not require manually tuning hyper-parameters but suffer from approximating a potentially indefinite Hessian with a positive-definite matrix. Hessian-free methods leverage the ability to perform Hessian-vector multiplication without needing the entire Hessian matrix, but each iteration's complexity is significantly greater than quasi-Newton methods. In this paper we propose an alternative approach for solving ML problems based on a quasi-Newton trust-region framework for solving large-scale optimization problems that allow for indefinite Hessian approximations. Numerical experiments on a standard testing data set show that with a fixed computational time budget, the proposed methods achieve better results than the traditional limited-memory BFGS and the Hessian-free methods.
<i>Bacteroides fragilis</i> Enterotoxin Gene Sequences in Patients with Inflammatory Bowel Disease (2000)

We identified enterotoxigenic Bacteroides fragilis in stool specimens of patients with inflammatory bowel disease and other gastrointestinal disorders. The organism was detected in 11 (13.2%) of 83 patients with inflammatory bowel disease. Of 57 patients with active disease, 19.3% were toxin positive; none of those with inactive disease had specimens positive for enterotoxigenic Bacteroides fragilis gene sequences.
Comments on "Sinc interpolation of discrete periodic signals (1998)

In a recent paper by T. Schanze (see ibid., vol.43, p.1502-3, 1995) the convolution of the sinc kernel with the infinite sequence of a periodic function was expressed as a finite summation. The expression obtained, however, is not numerically stable when evaluated at or near integer values of time. This correspondence presents a numerically stable formulation that is equivalent to the results reported in the above-cited paper and that, when sampled, is also shown to be equivalent to the inverse discrete Fourier transform (IDFT).
Optimization of Sidewall Masked Isolation Process (1985)

This paper presents modifications of the Sidewall Masked Isolation (SWAMI) process for VLSI device isolation which improve process reproducibility, eliminate stress induced defects, and permit flexibility in channel stop implant optimization. A novel "undercut-and-backfill" technique is introduced to eliminate a localized failure mechanism of the oxidation mask by increasing the strength of the nitride-to-nitride joint. The primary variable influencing stress-induced defect generation is the vertical length of the sidewall nitride mask as determined by the amount of recessed silicon etch prior to sidewall nitride formation. In general, a maximum length can be found below which defect-free structures can be fabricated. An optional second recessed silicon etch, following the formation of the sidewall nitride, has been developed which increases the flexibility in optimizing the channel stop implantation. Defect-free low-Ieakage devices with near-zero electrical channel width reduction have been obtained.
Petroglyph Survey Rocks On (2000)

Petroglyph in Oconee County similar to three others found 50 miles away in Pickens County
TOA Estimation for IR-UWB System Using Matrix Pencil (2009)

This paper presents a method to estimate Time of arrival (TOA) of impulse radio ultra wideband (IR-UWB) in a multipath communication channel. Matrix Pencil (MP) is used to recover these delays from the channel frequency response. This algorithm has some key advantages over traditional super-resolution techniques such as multiple signal classification (MUSIC) method. Most importantly, Matrix Pencil only requires a single channel estimate and can estimate the delays easier and faster. The results show that the root mean square error (RMSE) of the proposed method is similar to that of MUSIC method at low SNR, while is better at high SNR.
X-Ray structure of Ro 21-6150, a polyether antibiotic related to Dianemycin (1975)

J. F. Blount, R. H. Evans, C. Liu, T. Hermann and J. W. Westley, J. Chem. Soc., Chem. Commun., 1975, 853 DOI: 10.1039/C39750000853
Clinical Applications of <scp>l</scp>‐Glutamine: Past, Present, and Future (2003)

High-dose or parenteral (> 0.25 to 0.30 g/kg/day IV or >or=30 g/day enterally) glutamine appears to demonstrate the greatest potential for benefit in hospitalized patients. No evidence of harm has been observed in studies conducted to date; thus, further clinical trials using glutamine as a pharmacologic supplement to standard nutrition are warranted.
Food Availability and Pheromone Production by Males ofAnastrepha suspensa(Diptera: Tephritidae) (1993)

Journal Article Food Availability and Pheromone Production by Males of Anastrepha suspensa (Diptera: Tephritidae) Get access Nancy D. Epsky, Nancy D. Epsky Insect Attractants, Behavior, and Basic Biology Research Laboratory, USDA-ARS, Gainesville, FL 32604 Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert R. Heath Robert R. Heath 1 Insect Attractants, Behavior, and Basic Biology Research Laboratory, USDA-ARS, Gainesville, FL 32604 1 To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 22, Issue 5, 1 October 1993, Pages 942–947, https://doi.org/10.1093/ee/22.5.942 Published: 01 October 1993 Article history Received: 23 December 1992 Accepted: 17 May 1993 Published: 01 October 1993
High-Resolution Ocular Imaging: Combining Advanced Optics and Microtechnology (2009)

Recent developments in imaging technologies offer great potential for the assessment of retinal ganglion cell disorders, with particular relevance to glaucoma. In particular, advances in this field have allowed unprecedented in vivo access to the retinal layers, using many different properties of light to differentiate cellular structures. This article is a summary of currently available and investigational advanced, high-resolution imaging technologies and their potential applications to glaucoma. It represents the topics of discussion at the annual Optic Nerve Rescue and Restoration Think Tank, sponsored by The Glaucoma Foundation, entitled "High Resolution Imaging of the Eye: Advanced Optics, Microtechnology and Nanotechnology" and held in New York, New York, September 28-29, 2007.
Mechanism-Based Inactivation of Bacterial Aminoglycoside 3'-Phosphotransferases (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism-Based Inactivation of Bacterial Aminoglycoside 3'-PhosphotransferasesJuliatiek Roestamadji, Ioannis Grapsas, and Shahriar MobasheryCite this: J. Am. Chem. Soc. 1995, 117, 1, 80–84Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/ja00106a009https://doi.org/10.1021/ja00106a009research-articleACS PublicationsRequest reuse permissionsArticle Views356Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts