gebhart/patrepeval huggingface dataset:
Inotropic effect of triiodothyronine (T3) in low cardiac output following cardioplegic arrest and cardiopulmonary bypass: an initial experience in patients undergoing open heart surgery (1989)

A significant reduction in plasma free triiodothyronine (T3) (P lessthan 0.0001) has been observed in patients undergoing open heart surgery.The beneficial effect of T3 would appear to be associated with increasedsynthesis and utilization of myocardial high energy stores. We havetherefore administered T3 (4-10 micrograms iv) to 10 patients either whendifficulty was being experienced in weaning from cardiopulmonary bypass(CPB) support (n = 5), or when myocardial function remained extremely poor(n = 5), despite inotropic and intraaortic balloon pump support. Meanpreoperative NYHA functional class of the 10 patients was 3.2, leftventricular enddiastolic pressure (LVEDP) 20 mm Hg and ejection fraction(EF) 40%. The mean myocardial ischaemia time was 72 min (range 40-120 min).Within 1 h of T3 administration the mean plasma free T3 level had risenfrom 1.03 to 3.56 micrograms/ml and CPB was discontinued in all 5 cases.Balloon pump support (n = 2) was no longer essential within 3 h. At 1 h,the mean arterial pressure (MAP) had risen from 42 to 78 mm Hg, and heartrate (HR) from 90 to 104 beats/min; the left atrial pressure (LAP) hadfallen from 30 to 14 mm Hg, and the central venous pressure (CVP) from 20to 11 cm H2O. (All changes significant at P less than 0.0001.) Inotropicsupport had been significantly reduced or discontinued. To our knowledge,T3 has not been administered previously as an inotropic agent to patientswho have undergone cardiac surgery. We believe that T3 may have animportant role in the rescue of failing hearts following a period ofmyocardial ischaemia in patients who have undergone open heart surgery.
High-temperature operation of a diode-pumped passively Q-switched Nd:YAG/Cr4+:YAG laser (2009)

The output performances of a diode-pumped Nd:YAG laser passively Q-switched by Cr4+:YAG saturable absorber crystal were investigated function of temperature. Increase of the temperature from 25 to 150°C increased slightly the laser pulse energy, and did not change the pulse duration. Furthermore, an increased absorbed energy of the pump radiation was necessary at temperatures higher than 25°C in order to maintain Q-switch operation. Measurements concluded that Cr4+:YAG transmission did not vary when temperature increased to 150°C. The decrease of Nd:YAG emission cross section with temperature and the changes of resonator configuration due to thermal effects were considered as main reasons for this behavior. The results of this work are valuable for designing a laser-ignition system for industrial gas engine or automotive industry.
Crystal structure of activated ribulose-1,5-bisphosphate carboxylase complexed with its substrate, ribulose-1,5-bisphosphate (1991)

The three-dimensional structure of the complex of ribulose-1,5-bisphosphate carboxylase from Rhodospirillum rubrum, CO2, Mg2+, and ribulose bisphosphate has been determined with x-ray crystallographic methods to 2.6-A resolution. Ribulose-1,5-bisphosphate binds across the active site with the two phosphate groups in the two phosphate binding sites of the beta/alpha barrel. The oxygen atoms of the carbamate and the side chain of Asp-193 provide the protein ligands to the bound Mg2+ ion. The C2 and the C3 or C4 oxygen atoms of the substrate are also within the first coordination sphere of the metal ion. At the present resolution of the electron density maps, two slightly different conformations of the substrate, with the C3 hydroxyl group "cis" or "trans" to the C2 oxygen, can be built into the observed electron density. The two different conformations suggest two different mechanisms of proton abstraction in the first step of catalysis, the enolization of the ribulose 1,5-bisphosphate. Two loop regions, which are disordered in the crystals of the nonactivated enzyme, could be built into their respective electron density. A comparison with the structure of the quaternary complex of the spinach enzyme shows that despite the different conformations of loop 6, the positions of the Mg2+ ion, and most atoms of the substrate are very similar when superimposed on each other. There are, however, some significant differences at the active site, especially in the metal coordination sphere.
Further evidence that neurofilament light chain gene mutations can cause Charcot-Marie-Tooth disease type 2E (2001)

A missense mutation in the neurofilament light chain gene (NEFL, NF-L) at chromosome 8p21 was recently reported in a single Charcot-Marie-Tooth type 2 family (CMT2). This new CMT2 variant is designated CMT2E. The NEFL gene mutation showed co-segregation with the disease phenotype and is thus most likely the disease-causing mutation. However, the possibility that it is a closely linked rare polymorphism can not be ruled out with certainty. We observed a novel NEFL missense mutation in a second CMT family, providing supporting evidence that CMT2E is caused by NEFL gene mutations.
Experimental studies of electrokinetic conversions in fluid‐saturated porous medium (1996)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1996Experimental studies of electrokinetic conversions in fluid‐saturated porous mediumAuthors: Zhenya ZhuM. N. ToksözZhenya ZhuEarth Resources Lab, MIT and M. N. ToksözEarth Resources Lab, MIThttps://doi.org/10.1190/1.1826456 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1826456FiguresReferencesRelatedDetailsCited ByNumerical Study of Frequency-dependent Seismoelectric Coupling in Partially-saturated Porous Media12 December 2016 | MATEC Web of Conferences, Vol. 87Experimental studies of electrokinetic conversions in fluid‐saturated borehole modelsGEOPHYSICS, Vol. 64, No. 5 SEG Technical Program Expanded Abstracts 1996ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1996 Pages: 2106 publication data© 1996 Copyright © 1996 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Zhenya Zhu and M. N. Toksöz, (1996), "Experimental studies of electrokinetic conversions in fluid‐saturated porous medium," SEG Technical Program Expanded Abstracts : 1699-1702. https://doi.org/10.1190/1.1826456 Plain-Language Summary PDF DownloadLoading ...
The first anionic sulfonamide-binding zinc(II) complexes with a macrocyclic triamine: chemical verification of the sulfonamide inhibition of carbonic anhydrase (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe first anionic sulfonamide-binding zinc(II) complexes with a macrocyclic triamine: chemical verification of the sulfonamide inhibition of carbonic anhydraseTohru Koike, Eiichi Kimura, Ikushi Nakamura, Yukie Hashimoto, and Motoo ShiroCite this: J. Am. Chem. Soc. 1992, 114, 19, 7338–7345Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ja00045a002https://doi.org/10.1021/ja00045a002research-articleACS PublicationsRequest reuse permissionsArticle Views715Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Changes in Innominate Tilt After Manipulation of the Sacroiliac Joint in Patients with Low Back Pain (1988)

The purposes of this study were to 1) propose a method to detect sacroiliac joint dysfunction (SIJD), 2) test the interrater reliability of the method on a group of patients with low back pain (LBP), and 3) document changes in innominate tilt after manipulation of the sacroiliac joint. Criteria for SIJD were established by the authors. Twenty-six patients with unilateral LBP were examined independently for presence of SIJD by two examiners. Interrater agreement for presence or absence of SIJD was found to be excellent (Cohen's Kappa = .88). Twenty of the patients who met the criteria for SIJD were randomly assigned to an Experimental Group (n = 10) or a Control Group (n = 10). The left and right innominate bones of these 20 patients were measured for tilt before and after the intervention period. The sacroiliac joint of the patients in the Experimental Group was manipulated during the intervention period, whereas the patients in the Control Group received no treatment. Data were analyzed using a mixed three-factor analysis of variance. The data analysis revealed that the manipulation procedure resulted not only in an altered innominate tilt of the same side but also in an equal and opposite tilt of the opposite side (F = 67.07; df = 1.18; p less than .05). The results indicate that SIJD can be identified reliably in patients with LBP and that a manipulative procedure purported to be specific to the sacroiliac joint changes innominate tilt bilaterally and in opposite directions.
Chk1 and p21 Cooperate to Prevent Apoptosis during DNA Replication Fork Stress (2005)

Cells respond to DNA replication stress by triggering cell cycle checkpoints, repair, or death. To understand the role of the DNA damage response pathways in determining whether cells survive replication stress or become committed to death, we examined the effect of loss of these pathways on cellular response to agents that slow or arrest DNA synthesis. We show that replication inhibitors such as excess thymidine, hydroxyurea, and camptothecin are normally poor inducers of apoptosis. However, these agents become potent inducers of death in S-phase cells upon small interfering RNA-mediated depletion of the checkpoint kinase Chk1. This death response is independent of p53 and Chk2. p21-deficient cells, on the other hand, produce a more robust apoptotic response upon Chk1 depletion. p21 is normally induced only late after thymidine treatment. In Chk1-depleted cells p21 induction occurs earlier and does not require p53. Thus, Chk1 plays a primary role in the protection of cells from death induced by replication fork stress, whereas p21 mediates through its role in regulating entry into S phase. These findings are of potential importance to cancer therapy because we demonstrate that the efficacy of clinically relevant agents can be enhanced by manipulation of these signaling pathways.
Fundamental study on extracting lead from cerussite concentrate in methane sulfonic acid based solution (2012)

Cerussite (PbCO₃) concentrates may be recovered from oxidized lead ores. These concentrates suffer from the intrinsic fuel shortage via traditional smelting route and may lead to widespread contamination in shipment. Therefore, a hydro-electrometallurgical process to treat cerussite concentrate by methane sulfonic acid (MSA) is proposed to solve the above problems. The leaching of cerussite concentrate by MSA was first studied. The parameters of stirring speed, temperature, acid concentration, particle sizes and solid concentration were considered. It was found that stirring speed, temperature, particle size and proton concentration had a significant influence on the kinetics while solid concentration showed no effect on the final lead extraction under the experimental conditions. The leaching results indicated that MSA is favourable to treat cerussite concentrate and the lead extraction could achieve the theoretical maximum in just 10 min at ambient conditions. The lead content in solution obtained at high solid concentration was sufficiently high, and easily met the concentration requirements for the subsequent electrolysis process. After leaching, the residue was subjected to a desulfurization treatment to recover the remaining lead in residue. Using desulfurization agent Na₂CO₃, the remaining lead, mainly in anglesite, was transformed to PbCO₃ that was followed by a re-leaching treatment with MSA. An overall lead recovery of 98% was finally obtained. In the electrowinning process from MSA based electrolyte, the individual and synergistic effects of two ligninsulfonate salts and two glycol-type agents on lead deposit quality were first investigated. Compared to the other three additives, the individual use of calcium ligninsulfonate most benefited the morphology of lead deposit. The operating parameters in the lead electrowinning process (i.e. temperature, current density, concentrations of lead ion and protons) had a widely acceptable range. The cathodic current efficiency and specific energy consumption in most tests were around 99% and 0.53Wh/kg, respectively. The SEM micrographs showed that the lead deposits obtained under the optimal conditions were compact and even. These results for leaching and electrolysis made the MSA system competitive to the comparable fluoborate and fluosilicate systems. Finally a simplified flowsheet to extract lead from cerussite concentrate in MSA based solution was proposed.
Zur Synthese 2,6‐disubstituierter Piperidonmonocarbonsäureester (1965)

Abstract Für 2,6‐disubstituierte Piperidonmonocarbonsäureester wird eine Synthese beschrieben, die von freien Acetondicarbonsäuremonoalkylestern, gewonnen durch solvolytische Spaltung von 2,4,6‐Trioxotetrahydropyran mit verschiedenen Alkoholen, ausgeht. Piperidonringschluß mit heteroaromatischen oder aliphatischen Aldehyden und Benzylamin führt zu den Verbindungen II bis VII. Diese liegen in kristallinem Zustand in der Enolform vor, die als konjugiertes Chelat stabilisiert ist; in Lösung stellt sich ein Gleichgewicht zwischen Keto‐ und Enolform ein. Die pyridyl‐(2) substituierten Verbindungen bilden Metallchelate.
The Effect of Rainfall on NO and N2O Emissions from Ugandan Agroforest Soils (2001)

Agroforestry systems, often incorporating N-fixing trees, are widely used in tropical countries. However, the effect of such systems on the emissions of atmospheric pollutants NO and N2O is largely unknown. Here we compare the emissions from two agroforest systems, one where the tree component is the nitrogen fixing tree species (Calliandra calothyrsus) and the other where the tree component does not fix N (Grevillea robusta). The experiment simulated the first rainfall of a wet season, which has been shown to be a major source of NO and N2O emissions in tropical soils. Light (10 mm rain) and heavy rainfall (25 mm rain) was added to small repacked soil columns. Light rainfall resulted in a brief flush of NO up to 96 mug NO-N m(-2) h(-1) within 1 day of wetting. Nitrous oxide emissions were negligible, In contrast heavy rainfall produced a flush in N2O emissions up to 2000 mug N2O-N m(-2) h(-1), but no NO. Responses were at least 4 times larger for soils from the N fixing trees compared to the non-N fixing trees.
Antibacterial activity of 4,5-dihydroxy-2-cyclopentan-1-one (DHCP) and cloning of a gene conferring DHCP resistance in Escherichia coli. (2001)

In the present study we report that 4,5-dihydroxy-2-cyclopentan-1-one (DHCP), which is derived from heat-treatment of uronic acid or its derivatives, has antibacterial activity against Escherichia coli. The compound causes complete growth inhibition at 350 microM concentration. We have cloned a gene from E. coli, which confers DHCP resistance when present in multicopy. The putative protein encoded by this gene (dep- DHCP efflux protein) is a transmembrane efflux protein with a high homology to other antibiotic-efflux proteins including those for chloramphenicol, bicyclomycin and tetracycline. However, the Dep protein does not confer cross-resistance to any of the antibiotics tested.
Application of surgical navigation to total hip arthroplasty (2007)

Instability, impingement, and leg-length discrepancy are among the most common early problems following total hip arthroplasty (THA). Component positioning is the primary factor affecting all three of these issues and, therefore, all three can be potentially addressed using surgical navigation. While the advent of less invasive surgical techniques performed through smaller incisions has been shown to accelerate recovery, these techniques have also been associated with a further increase in the incidence of these three problems. Acetabular component malpositioning has been a particular problem with less invasive surgical techniques. Nonetheless, it is clear that maximal preservation of the soft tissues around the hip joint may accelerate recovery following surgery and confer greater hip joint stability. Accomplishing these goals without compromising component positioning is the single greatest potential advantage to the application of surgical navigation to THA. The present paper describes the general principles of surgical navigation in THA with respect to methods of tracking, methods of registration, the role of image-free and image-based navigation, and methods of measuring leg-length change during surgery. Further, a description is given of the clinical effect of combining surgical navigation with use of the superior capsulotomy technique of performing THA, which aims maximally to preserve the soft tissues surrounding the hip joint, allowing unrestricted progression of motion and weight-bearing following surgery. These methods have led to statistically significant acceleration of recovery, improvement in acetabular component positioning, and reductions in peri-operative surgical complications.
Omega‐three fatty acids in purslane (Portulaca oleracea) Tissues (1991)

Total lipids and omega‐3 fatty acids in purslane (Portulaca oleracea) were determined in leaves, stems and whole plants at three ages. Significant differences (P<0.05) existed in levels of total lipids among ages and between leaves and stems, but no relationship of age to plant part (>O5) was found. Contents of 18:3ω3,20:5ω3, 22:5ω3,22:6ω3,18:2ω6 and 18:loω9 showed that leaves were the richer source of omega‐3 acids at each age.
Friend-in-the-Middle Attacks: Exploiting Social Networking Sites for Spam (2011)

Friend-in-the-middle attacks on social networking sites can be used to harvest social data in an automated fashion. Attackers can then exploit this data for large-scale attacks using context-aware spam and social phishing. The authors prove the feasibility of such an attack and simulate the impact on Facebook. Alarmingly, all major social networking sites are vulnerable to this attack because they fail to appropriately secure the network layer.
New Zero-Voltage-Switching Phase-Shift Full-Bridge Converter With Low Conduction Losses (2005)

A new zero-voltage-switching (ZVS) phase-shift full-bridge (PSFB) converter with low conduction losses is proposed. It is based on the PSFB converter with series-connected two transformers, which features wide ZVS ranges. By adding a capacitor, the proposed converter overcomes the disadvantage of the based converter, such as the high circulating energy. Furthermore, the turns ratio of the transformers can be increased as well. Therefore, high efficiency of the proposed converter can be achieved. Operational principles and experimental results for a 100-W (5 V, 20 A) prototype are presented to validate the proposed converter.
Providing a Web-based view of your managed network (2002)

Supplying a network management view of your network is an excellent way to keep members of the network community informed on the status of your network. To demonstrate this, network management Web server (NMWS) software was developed to take images from Hewlett Packard's Open View (HPOV) network management software (NMS) and make them accessible via the World Wide Web. An NMS console from the operational database is started and displayed on a remote proxy management station dedicated to the NMWS software. The NMWS software determines what views of the network are displayed on its X window server and those windows are captured and saved as GIF files that are incorporated into HTML Web documents. The documents use HTML and HTTP techniques to provide timely and efficient client access to the NMS views. Since the interface between HPOV and the NMWS is X windows, this method could easily be adapted to other NMS platforms. Potential users of the NMWS software include ISP network operations centers (NOC) as well as Enterprise NOCs. These sites could use the software to provide a network management view to the network community in general. Techniques are also available to implement a restricted access policy.
Sorafenib versus cytotoxic chemotherapy for patients with advanced hepatocellular carcinoma: A retrospective, single-institution study. (2011)

339 Background: Prior to the sorafenib era, most of the advanced hepatocellular carcinoma (HCC) patients had to rely only on conventional cytotoxic chemotherapy. But the introduction of sorafenib in 2008 had given HCC patients additional option for their treatment. However, given that sorafenib has been a nonreimbursable drug under the Korea public health system, most of treatment strategy has largely been determined by patients' affordability of the drug rather than by difference in efficacy and toxicity of the two treatments. Therefore, we compared the efficacy and toxicity of the two treatments by observing HCC patients. Methods: From January 2002 to December 2009, 173 patients with unresectable HCC had been retrospectively analyzed. Among them, 44 (25.4%) had been treated with sorafenib and the remaining had received cytotoxic chemotherapy. We evaluated objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and toxicity profiles. Results: The median OS of sorafenib group was 23.0 weeks (95% CI, 8.1-37.9) vs. 43.6 weeks (95% CI, 34.0-37.9) for cytotoxic chemotherapy group. The median PFS for sorafenib group was 11.1 weeks (95% CI, 6.5-15.8) versus 12.4 weeks (95% CI, 8.1-16.7) for cytotoxic chemotherapy group. However, the difference in both findings had not been statistically significant (p=0.105 and p=0.496, respectively). ORR and DCR for sorafenib group were 2.3% and 52.3% versus 6.2% and 43.4% for cytotoxic chemotherapy group, respectively. Patients treated with chemotherapy had shown higher frequencies of grade 3 or 4 neutropenia, 19.7%, (vs. 0% for sorafenib). However, the group with sorafenib had reported a higher rate of all grade dermatologic toxicities such as hand-foot skin reaction, rash and pruritus. Conclusions: Our analysis indicates that efficacy of conventional chemotherapy is not inferior to that of sorafenib. Further research including novel target agent and cytotoxic chemotherapy is needed to improve clinical outcomes for advanced HCC. No significant financial relationships to disclose.