gebhart/patrepeval huggingface dataset:
Energy transport into the closed chest from a set of very-large mutually orthogonal coils (1963)

It is shown that high levels of energy can be transported by inductive coupling from a set of three very-large mutually orthogonal coils which are fixed in space to a single receiving coil inside the chest cavity or buried within the chest wall of an animal which is free to move about within a restricted portion of the field established by the coil set. Coil-excitation conditions and energy-transport-efficiency relationships are derived.
Dobutamine therapy in the home (1994)

Escalating costs of health care and the realization that home care is an alternative to hospitaliza tion has resulted in an increase in patients receiving home intravenous (IV) therapy. At St. Elizabeth Home Infusion, Dayton, Ohio, stage III or IV congestive heart failure (CHF) patients must be stabilized on dobutamine prior to acceptance. Dobutamine therapy in the home causes less interruption in the patient's lifestyle and provides convenience for the patient with CHF at a decreased cost of treatment. Although patient survival may not be prolonged, quality of life may be improved, and the number of hospitalizations are reduced. Key words: dobutamine, heart failure, inotropic, intermittent therapy
Molecular beam epitaxy of MnAs thin films on GaAs (1994)

We have successfully grown single-crystalline ferromagnetic MnAs thin films on (001) GaAs substrates by molecular beam epitaxy. By reflection high energy electron diffraction and x-ray measurements, the growth direction of the MnAs thin films was found to be [100] on (001) GaAs, and the epitaxial relationship was [0001] MnAs //[10] GaAs and [110] MnAs // [110] GaAs. Magnetization measurements at room temperature have revealed that the epitaxial MnAs thin films have strong magnetic anisotropy, and that the easy magnetization direction is in-plane, along the [110] axis of the MnAs thin films which is parallel to the [110] axis of the GaAs substrate, with almost perfect square hysteresis loops, relatively high remanent magnetization, and low coercive field.
Numerical simulations of vibration in phase-shifting interferometry (1996)

Computer simulations predict the expected rms measurement error in a phase-shifting interferometer in the presence of mechanical vibrations. The simulations involve a numerical resolution of a nonlinear mathematical model and are performed over a range of vibrational frequencies and amplitudes for three different phase-shift algorithms. Experimental research with an interference microscope and comparison with analytical solutions verify the numerical model.
Effect of small-sample adjustments for Cox test under non-nested linear regression models (2004)

We consider the effect of Godfrey and Pesaran's (1983) two small-sample adjustments for the Cox (1961, 1962) non-nested test statistic under linear regression models. Based on convenient representations of the test statistics in terms of the correlation coefficients, we compare the confidence contours of the test statistics.
Diverter Decision Aiding for In-Flight Diversions (1990)

It was determined that artificial intelligence technology can provide pilots with the help they need in making the complex decisions concerning en route changes in a flight plan. A diverter system should have the capability to take all of the available information and produce a recommendation to the pilot. Phase three illustrated that using Joshua to develop rules for an expert system and a Statice database provided additional flexibility by permitting the development of dynamic weighting of diversion relevant parameters. This increases the fidelity of the AI functions cited as useful in aiding the pilot to perform situational assessment, navigation rerouting, flight planning/replanning, and maneuver execution. Additionally, a prototype pilot-vehicle interface (PVI) was designed providing for the integration of both text and graphical based information. Advanced technologies were applied to PVI design, resulting in a hierarchical menu based architecture to increase the efficiency of information transfer while reducing expected workload. Additional efficiency was gained by integrating spatial and text displays into an integrated user interface.
A ΣΔ A/D converter insensitive to SEU effects (2003)

This paper discusses a /spl Sigma//spl Delta/ A/D converter insensitive to SEU effects. We concentrated our first study in the analog part of the converter, proving that it is inherently immune to SEU. Afterwards, we studied several implementations of digital filters in order to minimize the cost of protecting the digital part against radiation effects. The use of the /spl delta/-operator allows a significant reduction on the area to be protected, while maintaining converter performance. The obtained simulation results showed that the /spl Sigma//spl Delta/ architecture provides excellent possibilities to build SEU immune AD converters.
Amplification of adenosine deaminase gene sequences in deoxycoformycin-resistant rat hepatoma cells. (1983)

Deoxycoformycin-resistant rat hepatoma cells exhibit up to a 2000-fold increase in adenosine deaminase activity compared to the sensitive parental cells.The increased enzyme activity in these cells is accompanied by similar increases in 1) the amount of adenosine deaminase protein, 2) the relative rate of adenosine deaminase synthesis in vivo, and 3) adenosine deaminase mRNA activity.To further investigate the mechanismfs) responsible for the overproduction of adenosine deaminase in these cells, we have isolated a recombinant plasmid containing a 1.4-kilobase insert complementary to at least part of the adenosine deaminase mRNA.Using this cDNA as a specific hybridization probe, all deoxycoformycin-resistant variants were shown to have increased amounts of adenosine deaminase mRNA and gene sequences.The relative increase in the level of mRNA and gene copy number was similar to the relative increase in enzyme activity for most resistant cell lines.However, the degree of adenosine deaminase gene amplification in one deoxycoformycinresistant cell line (6-10-200) was 3-4-fold less than the relative increase in adenosine deaminase mRNA.These results indicate that the increased adenosine deaminase activity in deoxycoformycin-resistant rat hepatoma cells is due in large part, but not exclusively, to gene amplification.The ability to produce increased amounts of a particular protein appears to be a common mechanism by which tissue culture cells may develop resistance to a specific inhibitor of that protein (1).The mechanism responsible for the increased production of the target protein has been investigated in several drug-resistant tissue culture systems.The most notable of these are the overproduction of dihydrofolate reductase, a multifunctional enzyme possessing carbamyl-phosphate synthetase, aspartate transcarbamylase, and dihydroorotase activities, metallothionein I, and argininosuccinate synthetase in cells resistant to methotrexate, N-phosphonacety1-Laspartate, cadmium, and canavanine, respectively.Methotrexate-and canavanine-resistant cells produce increased amounts of a structurally normal enzyme (2-5).The increase in the amounts of enzyme synthesized by these cells has been shown to be the result of an increase in the rate of synthesis of these proteins (2,6).An increase in the amounts of mRNA ~_ _ _
Wheel Flat Detection in High-Speed Railway Systems Using Fiber Bragg Gratings (2013)

Wheel flats are a major source of problems in railway systems since they cause strong wear both in the infrastructure and in the train vehicles. In this paper, we present field tests concerning the application of Fiber Bragg Grating (FBG) sensors for the detection of out-of-roundness in high-speed train wheels. Wheel flats are shown to cause high-energy impacts on the rails that can be monitored using FBGs located in the rails. The results point out a great potential of this technology for the development of reliable wheel flat detection systems.
Specific Bovine Monoclonal Antibody Produced by a Re-Fused Mouse/Calf Hybridoma (1984)

Hybridomas made by fusing NSO (subline NSI Ag 4-1) mouse myeloma cells with lymph node cells from a calf immunized with sheep red blood cells failed to maintain antibody secretion in culture. However, when two of these hybridomas were selected in 8-azaguanine and then re-fused with immunized calf lymph node cells, several lines were obtained that secreted bovine Ig. One cloned line, producing bovine IgG1 (strongly lytic in the presence of rabbit complement and presumed to be an anti-Forssman) was maintained in culture for five months. Cytogenetic studies confirmed that the mouse/calf hybridomas lost bovine chromosomes as they proliferated, but that re-fusion increased the bovine complement from a mean of 5 (2 n) to 11 (2 n) bovine chromosomes per cell. It is proposed that the selected hybridoma lines may be suitable fusion partners for the production of further monoclonal bovine antibodies.
γ/δ T cell antigen receptors expressed on tumor‐infiltrating lymphocytes from patients with solid tumors (1992)

The expression of gamma/delta T cell antigen receptors (TcR) in T cell lines or clones derived from tumor-infiltrating lymphocytes (TIL) from patients with solid tumors was investigated. gamma/delta TcR T cell lines were derived from TIL from patients with Wilms tumor, sarcoma or metastatic melanoma by stimulation with autologous tumor cells alone and recombinant interleukin 2 and they exhibited nonspecific cytotoxicity against autologous and allogeneic tumor cells, or cells of the K562 or the MEL21 tumor cell lines. Two T cell lines were derived from a patient with Wilms tumor. One of them expressed a non-disulfide-linked gamma/delta TcR using the 60-kDa gamma chain, whereas, the other expressed a disulfide-linked gamma/delta TcR. A T cell line was derived from a patient with sarcoma and expressed a disulfide-linked gamma/delta TcR, whereas, a T cell line derived from a patient with melanoma expressed a non-disulfide-linked gamma chain of 62 kDa. Several T cell clones were developed from patients with metastatic melanoma or Wilms tumor and expressed either disulfide- or non-disulfide-linked gamma/delta TcR. Northern analysis of RNA from certain of these clones revealed a full-length gamma chain transcript, whereas, the alpha or beta chain transcripts were either absent or truncated. These T cell clones exhibited nonspecific cytotoxicity. Both disulfide- and non-disulfide-linked TIL T cell lines and clones expressed the delta TCS1 determinant. gamma/delta TcR+ cells in freshly prepared TIL from these patients were present in low proportions (less than 5%) and their delta TCS1/delta 1 ratios were within the range observed in the peripheral blood of normal donors. These results demonstrate that both disulfide- and non-disulfide-linked gamma/delta TcR are expressed on T cell lines and clones derived from TIL from solid tumors. Non-disulfide-linked gamma/delta TcR using the 56-66-kDa gamma chain are frequently found on TIL-derived T cell lines and clones. These 56-66-kDa gamma chains are rarely expressed on T cell lines or clones derived from peripheral blood lymphocytes of normal donors.
Synthesis and characterization of an oxasapphyrin-uranyl complex (1998)

J. L. Sessler and A. Gebauer, Chem. Commun., 1998, 1835 DOI: 10.1039/A803975E
Reflections on the Nature of Logic in Kant (2015)

Currently, there persists an argument between those who defend the existence of logical truths, understood as «logical facts or objects», and those who think that logic consists of «rules», the nature of which allows for the preservation of a property under a particular group of transformations. This paper has basically the purpose of rummaging about these problems through the Kantian conception of logic from a historical-constructive perspective. To that end, we begin by sketching the most significant contributions to the domain of logical investigation prior to Kant´s approach, with the purpose of becoming clear as to whether this philosopher has introduced any important changes regarding the nature of logic.
Stabilization of Red Blood Cells by the Plasticizer, Diethylhexylphthalate<sup>1</sup> (1985)

The red blood cells of blood stored in containers made of polyvinylchloride (PVC) film are osmotically more stable and lose on average about 1/3 less hemoglobin than when blood is stored in another plastic [poly-(ethylene-co-ethyl acrylate); EEA]. The stability of uniform volumes of stored red blood cells varies directly with PVC surface area, whereas changes in EEA surface area have comparatively little or no effect. PVC contains high concentrations of the plasticizer, diethylhexylphthalate (DEHP), known to migrate into blood and to have a high potential for toxicity. To determine if DEHP could be the red cell stabilizing agent in PVC, whole blood was stored in containers made from EEA into which was incorporated varying amounts of DEHP. Incorporation of DEHP into EEA significantly reduced erythrocyte osmotic fragility (p = 0.01). The degree of reduced fragility correlated with the level of DEHP in the cell phase implicating DEHP in PVC containers as the stabilizing agent for red cells.
PCR-based detection in a micro-fabricated platform (2008)

We present a novel, on-chip system for the electrokinetic capture of bacterial cells and their identification using the polymerase chain reaction (PCR). The system comprises a glass-silicon platform with a set of micro-channels, -chambers, and -electrodes. A platinum thin film resistor, placed in the proximity of the chambers, is used for temperature monitoring. The whole chip assembly is mounted on a Printed Circuit Board (PCB) and wire-bonded to it. The PCB has an embedded heater that is utilized for PCR thermal cycle and is controlled by a Lab-View program. Similar to our previous work, one set of electrodes on the chip inside the bigger chamber (0.6 microl volume) is used for diverting bacterial cells from a flowing stream into to a smaller chamber (0.4 nl volume). A second set of interdigitated electrodes (in smaller chamber) is used to actively trap and concentrate the bacterial cells using dielectrophoresis (DEP). In the presence of the DEP force, with the cells still entrapped in the micro-chamber, PCR mix is injected into the chamber. Subsequently, PCR amplification with SYBR Green detection is used for genetic identification of Listeria monocytogenes V7 cells. The increase in fluorescence is recorded with a photomultiplier tube module mounted over an epifluorescence microscope. This integrated micro-system is capable of genetic amplification and identification of as few as 60 cells of L. monocytogenes V7 in less than 90 min, in 600 nl volume collected from a sample of 10(4) cfu ml(-1). Specificity trials using various concentrations of L. monocytogenes V7, Listeria innocua F4248, and Escherichia coli O157:H7 were carried out successfully using two different primer sets specific for a regulatory gene of L. monocytogenes, prfA and 16S rRNA primer specific for the Listeria spp., and no cross-reactivity was observed.
Tissue-specific expression of functional isoforms of mouse folypoly-gamma-glutamae synthetase: a basis for targeting folate antimetabolites. (1999)

Folates and folate antimetabolites are metabolically trapped in mammalian cells as polyglutamates, a process catalyzed by folylpoly-gamma-glutamate synthetase (FPGS). Using 5'-rapid amplification of cDNA ends, RNase protection assays, transfection of cDNAs into FPGS-deficient cells, and kinetic analysis of recombinant enzymes expressed in insect cells, it was determined that the species of active FPGS in mouse liver and kidney was different from that in mouse tumor cells, bone marrow, and intestine. The NH2-terminal peptide of hepatic enzyme contained 18 amino acids not found in enzyme from dividing tissues, and the specificity of the two isoforms for antifolates also differed, suggesting different architecture of the active sites. In most tissues, the expression of one isozyme or the other was an all-or-nothing event. The exclusive use of one of two alternative sets of initial coding exons in different tissues underlies this phenomenon, suggesting the design of antifolates specific for activation by individual FPGS isoforms and hence tissue-selective targeting of antifolate therapy for cancer, arthritis, or psoriasis.
Active Tuning of Spontaneous Emission by Mie-Resonant Dielectric Metasurfaces (2018)

Mie-resonant dielectric metasurfaces offer comprehensive opportunities for the manipulation of light fields with high efficiency. Additionally, various strategies for the dynamic tuning of the optical response of such metasurfaces were demonstrated, making them important candidates for reconfigurable optical devices. However, dynamic control of the light-emission properties of active Mie-resonant dielectric metasurfaces by an external control parameter has not been demonstrated so far. Here, we experimentally demonstrate the dynamic tuning of spontaneous emission from a Mie-resonant dielectric metasurface that is situated on a fluorescent substrate and embedded into a liquid crystal cell. By switching the liquid crystal from the nematic state to the isotropic state via control of the cell temperature, we induce a shift of the spectral position of the metasurface resonances. This results in a change of the local photonic density of states, which, in turn, governs the enhancement of spontaneous emission from the substrate. Specifically, we observe spectral tuning of both the electric and magnetic dipole resonances, resulting in a 2-fold increase of the emission intensity at λ ≈ 900 nm. Our results demonstrate a viable strategy to realize flat tunable light sources based on dielectric metasurfaces.
Electro-Optical Properties in Thin Films of New Azobenzene Polymers (2015)

In this paper we report the synthesis of side chain methacrylic polymers functionalized with azobenzene chromophores.A reversible change of thin film absorption is observed when illuminating it with monochromatic, linearly polarized light under the applied external DC field.The amount of change depends on the angle between the light polarization and the DC electric field direction.
Silicon-containing anodes with high capacity loading for lithium-ion batteries (2014)

Comparative analysis of cycling performance of hybrid electrodes based on the MAG synthetic graphite mechanic mixtures with silicon nanopowder and “nano-Si/SiO2/hard carbon” ceramic frame-ordered composite in 1 M LiPF6 solution in a monofluoroethylene carbonate-ethyl methyl carbonate mixture (30: 70, v/v), added with 3 wt % vinylene carbonate and 2 wt % ethylene sulfite, is performed. The high capacity loading (up to 6.8 mA h cm−2 at the electrode layer thickness of 37 μm) and acceptable accumulated irreversible capacity of the composite-containing electrodes are achieved, due to the electrodes’ high density and stable silicon-containing electrode/electrolyte interface formation.
Cancer/testis antigen‐Plac1 promotes invasion and metastasis of breast cancer through Furin/ <scp>NICD</scp> / <scp>PTEN</scp> signaling pathway (2018)

Placenta-specific protein 1 (Plac1) is a cancer/testis antigen that plays a critical role in promoting cancer initiation and progression. However, the clinical significance and mechanism of Plac1 in cancer progression remain elusive. Here, we report that Plac1 is an important oncogenic and prognostic factor, which physically interacts with Furin to drive breast cancer invasion and metastasis. We have shown that Plac1 expression positively correlates with clinical stage, lymph node metastasis, hormone receptor status, and overall patient survival. Overexpression of Plac1 promoted invasion and metastasis of breast cancer cells in vitro and in vivo. Co-immunoprecipitation and immunofluorescence cell staining assays revealed that interaction of Plac1 and Furin degraded Notch1 and generated Notch1 intracellular domain (NICD) that could inhibit PTEN activity. These findings are consistent with the results of microarray study in MDA-MB-231 cells overexpressing Plac1. A rescue study showed that inhibition of Furin and overexpression of PTEN in Plac1 overexpression cells blocked Plac1-induced tumor cell progression. Taken together, our findings suggest that functional interaction between Plac1 and Furin enhances breast cancer invasion and metastasis and the Furin/NICD/PTEN axis may act as an important therapeutic target for breast cancer treatment.
Clinical associations and time of onset of cerebral white matter damage in very preterm babies. (1996)

Neuropathological examinations were carried out at necropsy on 83 very pre-term babies who died during their first hospital admission. Forty seven (57%) babies had evidence of cerebral damage-39 with ischaemic white matter damage. The time of onset of ischaemic lesions was thought to be prenatal in 12 cases (31%) and postnatal in a further 12 (31%). The exact timing of damage could not be determined in 15 (38%) cases. Maternal and neonatal case notes were reviewed to ascertain clinical associations of ischaemic white matter damage. There were no clear associations between adverse clinical factors and prenatal ischaemic white matter damage. In contrast, pre-eclampsia, intrauterine growth retardation, and delivery without labour were associated with postnatal damage as were neonatal sepsis, necrotising enterocolitis, and seizures. The absence of a clear association between the timing of adverse clinical factors and the timing of ischaemic cerebral damage suggests that cerebral damage in very preterm babies may result from a sequence of events rather than one specific insult.
Metal sulfide coated multiwalled carbon nanotubes synthesized by an<i>in situ</i>method and their optical limiting properties (2009)

A metal sulfide such as ZnS, CdS, Ag(2)S or PbS was coated on the sidewall of multiwalled carbon nanotubes (MWCNTs) by an in situ wet chemical synthesis approach via noncovalent functionalization of MWCNTs with a polyelectrolyte (polyethylenimine or poly(diallyldimethylammonium chloride)) without causing significant electronic and structural modification of the carbon nanotubes. Extensive characterizations of the fabricated nanocomposites have been performed using x-ray diffraction, transmission electron microscopy (TEM), high resolution TEM, energy dispersive x-ray spectroscopy, selected area electron diffraction, thermal gravimetric analysis, Fourier transform IR spectra, UV-vis spectra and x-ray photoelectron spectroscopy. The coating layers were composed of metal sulfide nanoparticles with a mean size of less than 10 nm. The optical limiting property measurements for some metal sulfide coated MWCNTs were carried out by the open-aperture z-scan technique. The results demonstrate that the samples suspended in water showed optical limiting behavior better than that of purified MWCNTs.
Phylogenetic Analysis of Polyketide Synthase I Domains from Soil Metagenomic Libraries Allows Selection of Promising Clones (2004)

The metagenomic approach provides direct access to diverse unexplored genomes, especially from uncultivated bacteria in a given environment. This diversity can conceal many new biosynthetic pathways. Type I polyketide synthases (PKSI) are modular enzymes involved in the biosynthesis of many natural products of industrial interest. Among the PKSI domains, the ketosynthase domain (KS) was used to screen a large soil metagenomic library containing more than 100,000 clones to detect those containing PKS genes. Over 60,000 clones were screened, and 139 clones containing KS domains were detected. A 700-bp fragment of the KS domain was sequenced for 40 of 139 randomly chosen clones. None of the 40 protein sequences were identical to those found in public databases, and nucleic sequences were not redundant. Phylogenetic analyses were performed on the protein sequences of three metagenomic clones to select the clones which one can predict to produce new compounds. Two PKS-positive clones do not belong to any of the 23 published PKSI included in the analysis, encouraging further analyses on these two clones identified by the selection process.