gebhart/patrepeval huggingface dataset:
<title>Color center formation and time-resolved photoluminescence for ArF excimer laser irradiation in CaF2 single crystals</title> (1998)

Time-resolved photoluminescence spectra of various grade CaF<SUB>2</SUB> single crystals were measured to examine effectiveness as a diagnosis for ArF excimer laser damage. Luminescence upon exciting with ArF laser light was classified into four bands from the peak position and lifetime, i.e., (1) 274 nm, 1 microsecond(s) , (2) 541 nm, 1 ms, (3) 418 nm, 700 ns, and (4) a doublet band 309 and 330 nm, 30 ns. Band 1 is emitted via 2-photon absorption processes and the origin is the relaxation of self-trapped exciton generated by band-to-band excitation. Therefore, this band is intrinsic to CaF<SUB>2</SUB> crystals. On the other hand, the bands 2, 3 and 4 originate from trace impurities. Tb<SUP>3+</SUP>, Eu<SUP>2+</SUP> and Ce<SUP>3+</SUP>, respectively. These luminescence bands occurred via on-photon absorption processes. When the band 2 (yellow green light) was clearly observed during the laser irradiation, the intense absorption band due to an F center associated with a trivalent yttrium ion was induced after prolonged irradiation. On the other hand, the band 3 (blue light) had no relationship with color center formation. It was suggested that photo-oxidation of trivalent rare earth ions has a correlation with color center formation.
Patterns of Policy Instrument Choice: Policy Styles, Policy Learning and the Privatization Experience (1993)

The spread of privatization in almost every country over the last decade reflects a rapid and fundamental change in patterns of policy instrument usage. Yet the literature on policy instruments has almost nothing to say on this perhaps most significant development in public policy in recent times. This paper's objective is to aid in the development of a theory of policy instrument choice which is capable of dealing with instances of long‐term, cross‐national changes in policy instrument usage. It will be argued that reconceptualization of instrument choices in terms of policy learning can aid in this theoretical project.
Florence Nightingale: Creator of Modern Nursing and Public Health Pioneer (2008)

In starting this series of articles on distinguished women in nursing, medicine and the related healthcare professions, the choice of the first name is obvious. Florence Nightingale is, I suggest, the most famous female in the long history of medicine and is a name that is known and revered throughout the world. Most people--even those in 'the trade'--think of her as 'the lady with the lamp', the heroine who went out to the Crimean War and nursed the sick and wounded at Scutari. Important though this was, her main contribution was her continued work, long after the war, in nursing organisation and training, hospital planning, public and military health and her pioneering work in the efficient gathering of medical statistics.
Optimization of array subscript range checks (1992)

Compile-time elimination of subscript range checks is performed by some optimizing compilers to reduce the overhead associated with manipulating array data structures. Elimination and propagation, the two methods of subscript range check optimization, are less effective for eliminating global redundancies especially in while-loop structures with nonconstant loop guards. This paper describes a subscript range check optimization procedure that can eliminate more range checks than current methods. Two transformations called inner-loop guard elimination and conservative expression substitution are introduced to enhance propagation of range checks in nested while-loops and to define a partial order on related range checks. Global elimination is improved by considering range checks performed before control reaches a statement and after control leaves a statement. A unique feature of this method is the simplification of the available range-check analysis system for global elimination.
Antisense ribosomes: rRNA as a vehicle for antisense RNAs. (1996)

Although rRNA has a conserved core structure, its size varies by more than 2000 bases between eubacteria and vertebrates, mostly due to the size variation of discrete variable regions. Previous studies have shown that insertion of foreign sequences into some of these variable regions has little effect on rRNA function. These properties make rRNA a potentially very advantageous vehicle to carry other RNA moieties with biological activity, such as "antisense RNAs." We have explored this possibility by inserting antisense RNAs targeted against one essential and two nonessential genes into a site within a variable region in the Tetrahymena thermophila large subunit rRNA gene. Expression of each of the three genes tested can be drastically reduced or eliminated in transformed T. thermophila lines containing these altered rRNAs. In addition, we found that only antisense rRNAs containing RNA sequences complementary to the 5' untranslated region of the targeted mRNA were effective. Lines containing antisense rRNAs targeted against either of the nonessential genes grow well, indicating that the altered rRNAs fulfill their functions within the ribosome. Since functional rRNA is extremely abundant and stable and comes into direct contact with translated mRNAs, it may prove to be an unparalleled vehicle for enhancing the activity of functional RNAs that act on mRNAs.
Intrusion detection system based on the analysis of time intervals of CAN messages for in-vehicle network (2016)

Controller Area Network (CAN) bus in the vehicles is a de facto standard for serial communication to provide an efficient, reliable and economical link between Electronic Control Units (ECU). However, CAN bus does not have enough security features to protect itself from inside or outside attacks. Intrusion Detection System (IDS) is one of the best ways to enhance the vehicle security level. Unlike the traditional IDS for network security, IDS for vehicle requires light-weight detection algorithm because of the limitations of the computing power of electronic devices reside in cars. In this paper, we propose a light-weight intrusion detection algorithm for in-vehicle network based on the analysis of time intervals of CAN messages. We captured CAN messages from the cars made by a famous manufacturer and performed three kinds of message injection attacks. As a result, we find the time interval is a meaningful feature to detect attacks in the CAN traffic. Also, our intrusion detection system detects all of message injection attacks without making false positive errors.
Absorption and Excretion of Luteolin and Apigenin in Rats after Oral Administration of <i>Chrysanthemum morifolium</i> Extract (2006)

Chrysanthemum morifolium extract (CME) has the protective effect on cardiovascular diseases. Luteolin and apigenin are two major bioactive components in vivo when CME is orally administrated to experimental animal. The present paper shows the study of the absorption and excretion of luteolin and apigenin in rats after a single oral dose of CME (200 mg/kg). The levels of luteolin and apigenin in plasma, urine, feces, and bile were measured by HPLC after deconjugation with hydrochloric acid or beta-glucuronidase/sulfatase. The results showed that the plasma concentrations of luteolin and apigenin reached the highest peak level at 1.1 and 3.9 h after dosing, respectively. The area under the concentration-time curves (AUC) for luteolin and apigenin were 23.03 and 237.6 microg h mL-1, respectively. The total recovery of the dose was 37.9% (6.6% in urine; 31.3% in feces) for luteolin and 45.2% (16.6% in urine; 28.6% in feces) for apigenin. The cumulative luteolin and apigenin excreted in the bile was 2.05% and 6.34% of the dose, respectively. All of the results suggest apigenin may be absorbed more efficiently than luteolin in CME in rats, and both luteolin and apigenin have a slow elimination phase, with a quick absorption, so a possible accumulation of the two flavonoids in the body can be hypothesized.
The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility. (1993)

The extracellular matrix-associated protein, SPARC (osteonectin [Secreted Protein Acidic and Rich in Cysteine]), modulates cell adhesion and induces a change in cell morphology. SPARC expression in mammals is developmentally regulated and is highest at sites of extracellular matrix assembly and remodeling such as parietal endoderm and bone. We have isolated cDNA and genomic DNA clones encoding the Caenorhabditis elegans homologue of SPARC. The gene organization is highly conserved, and the proteins encoded by mouse, human, and nematode genes are about 38% identical. SPARC consists of four domains (I-IV) based on predicted secondary structure. Using bacterial fusion proteins containing nematode domain I or the domain IV EF-hand motif, we show that, like the mammalian proteins, both domains bind calcium. In transgenic nematodes expressing a SPARC-lacZ fusion gene, beta-galactosidase staining accumulated in a striated pattern in the more heavily stained muscle cells along the body. Comparison of the pattern of transgene expression to unc-54-lacZ animals demonstrated that SPARC is expressed by body wall and sex muscle cells. Appropriate levels of SPARC are essential for normal C. elegans development and muscle function. Transgenic nematodes overexpressing the wild-type SPARC gene were abnormal. Embryos were deformed, and adult hermaphrodites had vulval protrusions and an uncoordinated (Unc) phenotype with reduced mobility and paralysis.
A 300-GHz Fundamental Oscillator in 65-nm CMOS Technology (2011)

Fundamental oscillators prove the existence of gain at high frequencies, revealing the speed limitations of other circuits in a given technology. This paper presents an oscillator topology that employs feedback from an output stage to the core, thus achieving a high speed. The behavior of the proposed oscillator is formulated and simulations are used to compare it with the conventional cross-coupled pair circuit. Three prototypes realized in 65-nm CMOS technology operate at 205 GHz, 240 GHz, and 300 GHz, each drawing 3.7 mW from a 0.8-V supply.
Multiple Components of the HSP90 Chaperone Complex Function in Regulation of Heat Shock Factor 1 In Vivo (1999)

Rapid and transient activation of heat shock genes in response to stress is mediated in eukaryotes by the heat shock transcription factor HSF1. It is well established that cells maintain a dynamic equilibrium between inactive HSF1 monomers and transcriptionally active trimers, but little is known about the mechanism linking HSF1 to reception of various stress stimuli or the factors controlling oligomerization. Recent reports have revealed that HSP90 regulates key steps in the HSF1 activation-deactivation process. Here, we tested the hypothesis that components of the HSP90 chaperone machine, known to function in the folding and maturation of steroid receptors, might also participate in HSF1 regulation. Mobility supershift assays using antibodies against chaperone components demonstrate that active HSF1 trimers exist in a heterocomplex with HSP90, p23, and FKBP52. Functional in vivo experiments in Xenopus oocytes indicate that components of the HSF1 heterocomplex, as well as other components of the HSP90 cochaperone machine, are involved in regulating oligomeric transitions. Elevation of the cellular levels of cochaperones affected the time of HSF1 deactivation during recovery: attenuation was delayed by immunophilins, and accelerated by HSP90, Hsp/c70, Hip, or Hop. In immunotargeting experiments with microinjected antibodies, disruption of HSP90, Hip, Hop, p23, FKBP51, and FKBP52 delayed attenuation. In addition, HSF1 was activated under nonstress conditions after immunotargeting of HSP90 and p23, evidence that these proteins remain associated with HSF1 monomers and function in their repression in vivo. The remarkable similarity of HSF1 complex chaperones identified here (HSP90, p23, and FKBP52) and components in mature steroid receptor complexes suggests that HSF1 oligomerization is regulated by a foldosome-type mechanism similar to steroid receptor pathways. The current evidence leads us to propose a model in which HSF1, HSP90 and p23 comprise a core heterocomplex required for rapid conformational switching through interaction with a dynamic series of HSP90 subcomplexes.
Refined Regio- and Stereoselective Hydroxylation of <scp>l</scp>-Pipecolic Acid by Protein Engineering of <scp>l</scp>-Proline <i>cis</i>-4-Hydroxylase Based on the X-ray Crystal Structure (2014)

Enzymatic regio- and stereoselective hydroxylation are valuable for the production of hydroxylated chiral ingredients. Proline hydroxylases are representative members of the nonheme Fe(2+)/α-ketoglutarate-dependent dioxygenase family. These enzymes catalyze the conversion of L-proline into hydroxy-L-prolines (Hyps). L-Proline cis-4-hydroxylases (cis-P4Hs) from Sinorhizobium meliloti and Mesorhizobium loti catalyze the hydroxylation of L-proline, generating cis-4-hydroxy-L-proline, as well as the hydroxylation of L-pipecolic acid (L-Pip), generating two regioisomers, cis-5-Hypip and cis-3-Hypip. To selectively produce cis-5-Hypip without simultaneous production of two isomers, protein engineering of cis-P4Hs is required. We therefore carried out protein engineering of cis-P4H to facilitate the conversion of the majority of L-Pip into the cis-5-Hypip isomer. We first solved the X-ray crystal structure of cis-P4H in complex with each of L-Pro and L-Pip. Then, we conducted three rounds of directed evolution and successfully created a cis-P4H triple mutant, V97F/V95W/E114G, demonstrating the desired regioselectivity toward cis-5-Hypip.
Catalytic Oxidation of Ammonia on RuO<sub>2</sub>(110) Surfaces:  Mechanism and Selectivity (2005)

The selective oxidation of ammonia to either N2 or NO on RuO2(110) single-crystal surfaces was investigated by a combination of vibrational spectroscopy (HREELS), thermal desorption spectroscopy (TDS) and steady-state rate measurements under continuous flow conditions. The stoichiometric RuO2(110) surface exposes coordinatively unsaturated (cus) Ru atoms onto which adsorption of NH3 (NH3-cus) or dissociative adsorption of oxygen (O-cus) may occur. In the absence of O-cus, ammonia desorbs completely thermally without any reaction. However, interaction between NH3-cus and O-cus starts already at 90 K by hydrogen abstraction and hydrogenation to OH-cus, leading eventually to N-cus and H2O. The N-cus species recombine either with each other to N2 or with neighboring O-cus leading to strongly held NO-cus which desorbs around 500 K. The latter reaction is favored by higher concentrations of O-cus. Under steady-state flow condition with constant NH3 partial pressure and varying O2 pressure, the rate for N2 formation takes off first, passes through a maximum and then decreases again, whereas that for NO production exhibits an S-shape and rises continuously. In this way at 530 K almost 100% selectivity for NO formation (with fairly high reaction probability for NH3) is reached.
A short note on implementing thread exclusiveness and address space locking (1994)

A thread can make itself exclusive by disabling execution of all other threads running in the same address space. This brute force synchronization mechanism is useful in cases otherwise requiring numerous semaphore or mutex operations or when synchronizytion has to be added to existing software. Based on the L3 experiences, the paper describes how to implement exclusiveness by locking the relevant region of a task's address space. This optimistic method scales better than suspending and later reactivating all threads explicitly.
A Self‐Powered Implantable Drug‐Delivery System Using Biokinetic Energy (2017)

The first triboelectric-nanogenerator (TENG)-based self-powered implantable drug-delivery system is presented. Pumping flow rates from 5.3 to 40 µL min<sup>-1</sup> under different rotating speeds of the TENG are realized. The implantable drug-delivery system can be powered with a TENG device rotated by human hand motion. Ex vivo trans-sclera drug delivery in porcine eyes is demonstrated by utilizing the biokinetic energies of human hands.
Room-temperature operation of a 2.25 μm electrically pumped laser fabricated on a silicon substrate (2009)

We report on a GaSb-based type-I laser structure grown by molecular beam epitaxy on a (001) silicon substrate. A thin AlSb nucleation layer followed by a 1 μm thick GaSb buffer layer was used to accommodate the very large lattice mismatch existing with the silicon substrate. Processed devices with mesa geometry exhibited laser operation in pulsed mode with a duty cycle up to 10% at room temperature.
Glycine Prevents Apoptosis of Rat Sinusoidal Endothelial Cells Caused by Deprivation of Vascular Endothelial Growth Factor (2000)

Apoptosis of sinusoidal endothelial cells (SECs) is one of the initial events in the development of ischemia-reperfusion injury of the liver. Glycine has been shown to diminish ischemia-reperfusion injury in the liver and improve graft survival in the rat liver transplantation model. Here, we investigated the effect of glycine on apoptosis of primary cultured rat SECs induced by vascular endothelial growth factor (VEGF) deprivation. Isolated rat SECs were cultured in EBM-2 medium supplemented with 10% fetal bovine serum (FBS) and growth factors including 20 ng/mL VEGF for 3 days. SECs at 3 days of culture showed spindle-like shapes; however, cells started shrinking and detaching from dishes by VEGF deprivation. Apoptosis was detected by terminal deoxynucleotidyl transferase (TdT)-mediated d-uridine triphosphate (dUTP)-biotin nick end labeling (TUNEL) staining in these conditions. Control SECs contained only a few percent of TUNEL-positive cells; however, they started increasing 4 hours after VEGF deprivation, and the percentage of TUNEL-positive cells reached about 50% at 8 hours and almost 100% at 16 hours after VEGF deprivation. Interestingly, this increase in TUNEL-positive cells after VEGF deprivation was prevented significantly when glycine (1-10 mmol/L) was added to the medium, the levels being around 60% of VEGF deprivation without glycine. Furthermore, strychnine (1 micromol/L), a glycine receptor antagonist, inhibited this effect of glycine, suggesting the possible involvement of the glycine receptor/chloride channel in the mechanism. Moreover, Bcl-2 protein levels in SECs were decreased 8 hours after VEGF deprivation, which was prevented almost completely by glycine. It is concluded that glycine prevents apoptosis of primary cultured SECs under VEGF deprivation.
The synthesis of oligoribonucleotides. III. The use of silyl protecting groups in nucleoside and nucleotide chemistry. VIII (1979)

The synthesis of all isomeric mono- and disilyl derivatives of cytidine, guanosine, and their N-benzoyl analogues using the tert-butyldimethylsilyl protecting group is described. These compounds and those containing a 5′-monomethoxytrityl group have been condensed via the phosphodichloridite procedure to produce nucleotides rapidly and in good yields. The synthesis of 2′–5′-linked nucleotides is described. A cautionary note is introduced in regard to the preparation of 5′-monomethoxytritylguanosine and a novel methanolysis of certain N-benzoylcytidines is mentioned.
Analysis Of Complex Gas Mixtures By Pattern Recognition With Polymer Based Quartz Microbalance Sensor Arrays (2005)

Polymer coated quartz microbalance gas sensor arrays were used to analyse quaternary mixtures of volatile or game compounds. The performance of the sensor arrays in combination with qualitative data evaluation utilising self-organising feature maps is described. The concept of context preservation artificial neural networks is compared to standard topology preservation with respect to its classification properties for model partitioning. In the studied case, context preserving maps yield more compact clusters with smaller map dimensions.
BASF 13.338 INDUCED CHANGES IN STRUCTURE and FUNCTION OF THE PHOTOSYNTHETIC APPARATUS OF WHEAT SEEDLINGS (1985)

Abstract— Growing wheat seedlings in the presence of BASF 13.338 [4‐chloro‐5‐dimethylamino‐2‐phenyl‐3(2H)pyridazinone], a PS II inhibitor of the pyridazinone group, brought about notable changes in the structure and functioning of photosynthetic apparatus. In BASF 13.338 treated plants, there was a decrease in the ratio of Chi a/Chl b , an increase in xanthophyll/carotene ratio and an increase in the content of Cyt b 559 (HP + LP). Chl/p700 ratio increased when measured with the isolated chloroplasts but not with the isolated PS I particles of the treated plants. The SDS‐PAGE pattern of chloroplast preparations showed an increase in the CPII/CP I ratio. The F685/F740 ratio in the emission spectrum of chloroplasts at ‐196°C increased. The difference absorption spectrum of chloroplasts between the control and the treated plants showed a relative increase of a chlorophyll component with a peak absorption at 676 nm and a relative decrease of a chlorophyll component with a peak absorption at 692 nm for the treated plants. The excitation spectra of these chloroplast preparations were similar. Chloroplasts from the treated plants exhibited a greater degree of grana stacking as measured by the chlorophyll content in the 10 K pellet. The rate of electron transfer through photosystem II at saturating light intensity in chloroplast thylakoids isolated from the treated plants increased (by 50%) optimally at treatment of 125 μ M BASF 13.338 as compared to the control. This increase was accompanied by an increase in (a) I 50 value of DCMU inhibition of photosystem II electron transfer; (b) the relative quantum yield of photosystem II electron transfer; (c) the magnitude of C550 absorbance change; and (d) the rate of carotenoid photobleaching. These observations were interpreted in terms of preferential synthesis of photosystem II in the treated plants. The rate of electron transfer through photosystems I and through the whole chain (H 2 O → methyl viologen) also increased, due to an additional effect of BASF 13.338, namely, an increase in the rate of electron transfer through the rate limiting step (between plastoquinol and cytochrome f ). This was linked to an enhanced level of functional cytochrome f . The increase in the overall rate of electron transfer occurred in spite of a decrease in the content of photosystem I relative to photosystem II. Treatment with higher concentrations (> 125 μ M ) of BASF 13.338 caused a further increase in the level of cytochrome f , but the rate of electron transfer was no greater than in the control. This was due to an inhibition of electron transfer at several sites in the chain.
Identification of the adherent microbiota on the gills and skin of poly-cultured gibel carp (Carassius auratus gibelio) and bluntnose black bream (Megalobrama amblycephala Yih) (2010)

PCR-denaturing gradient gel electrophoresis (DGGE) was applied to analyse the microbial community attached to the gills and skin of poly-cultured gibel carp (Carassius auratus gibelio) and bluntnose black bream (Megalobrama amblycephala Yih) and compare these results with those detected in the rearing water. The microbiota discussed included bacteria, fungi and a specific bacterial taxa of actinomycetes was also analysed. Proteobacteria, Firmicutes, Actinobacteria, Cyanobacteria, Ascomycota, Basidiomycota and some unclassified microbiota were identified. Based on our results, we concluded that: (1) the adherent bacterial/fungal communities on the gills and skin were different from those in the rearing water, (2) the bacterial/fungal diversities on fish gills were lower than that on fish skin, (3) the adherent bacterial/fungal communities on gill and skin of gibel carp were different from that of bluntnose black bream and (4) the adherent actinomycetal community showed certain similarity between the skin of different hosts. Based on our conclusions, we suggested that the topic investigated in the present study merits further investigations.