gebhart/patrepeval huggingface dataset:
Spin transport in graphite and graphene spin valves (2009)

Spin transport in graphene devices has been investigated in both local and non-local spin valve geometries. In the nonlocal measurement, spin transport and spin precession in single layer and bilayer graphene have both been achieved with transparent Co contacts. Gate controllable non-local spin signal was also demonstrated in this system. For the local graphite spin valve device, we report MR up to 12% for devices with tunneling contacts. We observe a correlation between the nonlinearity of the I-V curve and the presence of local MR and conclude that tunnel barriers can be employed to surmount the conductance mismatch problem in this system. These studies indicate that the improvement of tunnel barriers on graphene, especially to inhibit the formation of pinholes, is an important step to achieve more efficient spin injection into graphene.
Presence of negative and positive cis-acting RNA splicing elements within and flanking the first tat coding exon of human immunodeficiency virus type 1. (1994)

The human immunodeficiency virus type 1 (HIV-1) RNA follows a complex splicing pathway in which a single primary transcript either remains unspliced or is alternatively spliced to more than 30 different singly and multiply spliced mRNAs. We have used an in vitro splicing assay to identify cis elements within the viral genome that regulate HIV-1 RNA splicing. A novel splicing regulatory element (SRE) within the first tat coding exon has been detected. This element specifically inhibits splicing at the upstream 3' splice site flanking this tat exon. The element only functions when in the sense orientation and is position dependent when inserted downstream of a heterologous 3' splice site. In vivo, an HIV-1 SRE mutant demonstrated a decrease in unspliced viral RNA, increased levels of single- and double-spliced tat mRNA, and reduced levels of env and rev mRNAs. In addition to the negative cis-acting SRE, the flanking 5' splice site downstream of the first tat coding exon acts positively to increase splicing at the upstream 3' splice sites. These results are consistent with hypotheses of bridging interactions between cellular factors that bind to the 5' splice site and those that bind at the upstream 3' splice site.
A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization. (1976)

Four proteins active in blood coagulation have long been known to require vitamin K for their proper biosynthesis: factors II, VII, IX, and X. This paper describes the purification of a hitherto unrecognized vitamin K-dependent glycoprotein from bovine plasma. The biosynthesis of this protein is interfered with by the vitamin K antagonist Dicoumarol. The molecular weight of the protein is approximately 56,000 and, like factor X, it has two polypeptide chains. The light chain binds Ca2+. Its NH2-terminal amino acid sequence is homologous to the NH2-terminal sequences of the other vitamin K-dependent proteins and it contains vitamin K-dependent gamma-carboxyglutamic acid residues. The biological function of this protein is unknown.
Antidepressant Agents. Derivatives of 2,3-Polymethyleneindoles<sup>1</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntidepressant Agents. Derivatives of 2,3-Polymethyleneindoles1Leonard M. Rice, Elisabeth Hertz, and Meier E. FreedCite this: J. Med. Chem. 1964, 7, 3, 313–319Publication Date (Print):May 1, 1964Publication History Published online1 May 2002Published inissue 1 May 1964https://pubs.acs.org/doi/10.1021/jm00333a014https://doi.org/10.1021/jm00333a014research-articleACS PublicationsRequest reuse permissionsArticle Views213Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage (2008)

The zinc finger transcription factor GATA-1 requires direct physical interaction with the cofactor friend of GATA-1 (FOG-1) for its essential role in erythroid and megakaryocytic development. We show that in the mast cell lineage, GATA-1 functions completely independent of FOG proteins. Moreover, we demonstrate that FOG-1 antagonizes the fate choice of multipotential progenitor cells for the mast cell lineage, and that its down-regulation is a prerequisite for mast cell development. Remarkably, ectopic expression of FOG-1 in committed mast cell progenitors redirects them into the erythroid, megakaryocytic, and granulocytic lineages. These lineage switches correlate with transcriptional down-regulation of GATA-2, an essential mast cell GATA factor, via switching of GATA-1 for GATA-2 at a key enhancer element upstream of the GATA-2 gene. These findings illustrate combinatorial control of cell fate identity by a transcription factor and its cofactor, and highlight the role of transcriptional networks in lineage determination. They also provide evidence for lineage instability during early stages of hematopoietic lineage commitment.
Advanced coherent lightwave technologies (1988)

The present state of optical coherent communication technologies, covering optical heterodyne/homodyne detection and optical frequency division multiplexing (optimal FDM), is discussed. Included is a description of the development history of coherent lightwave communication technology followed by a discussion of heterodyne detection for future long-haul high-speed systems. A description of optical coherent transmission systems using heterodyne/homodyne detection is presented along with a review of optical FDM technology and its applications. Future trends are examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Evidence for Substrate-Specific Requirement of the Splicing Factor U2AF <sup>35</sup> and for Its Function after Polypyrimidine Tract Recognition by U2AF <sup>65</sup> (1999)

U2 snRNP auxiliary factor (U2AF) promotes U2 snRNP binding to pre-mRNAs and consists of two subunits of 65 and 35 kDa, U2AF(65) and U2AF(35). U2AF(65) binds to the polypyrimidine (Py) tract upstream from the 3' splice site and plays a key role in assisting U2 snRNP recruitment. It has been proposed that U2AF(35) facilitates U2AF(65) binding through a network of protein-protein interactions with other splicing factors, but the requirement and function of U2AF(35) remain controversial. Here we show that recombinant U2AF(65) is sufficient to activate the splicing of two constitutively spliced pre-mRNAs in extracts that were chromatographically depleted of U2AF. In contrast, U2AF(65), U2AF(35), and the interaction between them are required for splicing of an immunoglobulin micro; pre-RNA containing an intron with a weak Py tract and a purine-rich exonic splicing enhancer. Remarkably, splicing activation by U2AF(35) occurs without changes in U2AF(65) cross-linking to the Py tract. These results reveal substrate-specific requirements for U2AF(35) and a novel function for this factor in pre-mRNA splicing.
The arithmetic translator-compiler of the IBM FORTRAN automatic coding system (1959)

article Free Access Share on The arithmetic translator-compiler of the IBM FORTRAN automatic coding system Author: Peter B. Sheridan IBM Corp., New York, NY IBM Corp., New York, NYView Profile Authors Info & Claims Communications of the ACMVolume 2Issue 2Feb. 1959pp 9–21https://doi.org/10.1145/368280.368289Published:01 February 1959Publication History 42citation663DownloadsMetricsTotal Citations42Total Downloads663Last 12 Months81Last 6 weeks5 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Evolution of the secretoglobins: a genomic and proteomic view (2005)

Mouse salivary androgen-binding protein (ABP) is a member of the newly erected secretoglobin family, no member of which has yet been assigned an indisputable function. We have suggested a role for ABP in mate selection behaviour and sexual isolation. Although this has been a particularly attractive hypothesis given the evidence for strong positive selection on its alpha subunit gene, Abpa , we have held out the possibility that there might be an as-yetundiscovered primary function for ABP. This is particularly important in light of its membership in the secretoglobin family, and we are pursuing the broader issue of shared functions of the secretoglobins with genomic and bioinformatic studies. Here we present as complete a comparison as possible of the secretoglobins in the genomes of three species of mammals: mouse, rat and human, and we compare the protein sequences and their potential evolutionary relationships. We suggest that the secretoglobins can be divided into at least five families. In rodent and human genomes, these gene families are found in two main clusters that are syntenic between rat and mouse. Humans have only the three families that are found within the uteroglobin/clara cluster, because no ABP-containing secretoglobin cluster has yet been identified.
[no title] (1972)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Dehydrogenation of 1-Butene into Butadiene. Kinetics, Catalyst Coking, and Reactor Design (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDehydrogenation of 1-Butene into Butadiene. Kinetics, Catalyst Coking, and Reactor DesignFrancis J. Dumez and Gilbert F. FromentCite this: Ind. Eng. Chem. Process Des. Dev. 1976, 15, 2, 291–301Publication Date (Print):April 1, 1976Publication History Published online1 May 2002Published inissue 1 April 1976https://pubs.acs.org/doi/10.1021/i260058a014https://doi.org/10.1021/i260058a014research-articleACS PublicationsRequest reuse permissionsArticle Views2584Altmetric-Citations135LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
PRESUMPTIVE REOVIRUS INFECTION IN BROILER BREEDERS (2014)

Tenosynovitis is one of the pathological manifestations of avian reovirus infection and are of economic importance, special in one of the most important stages of the poultry industry, i.e., broiler breeders. In late May 2012, an outbreak of unilateral lameness occurred in a broiler breeder flock (15,000 birds divided by two houses) of a multi-age farm, with a total of four broiler breeder flocks (65,000 birds in total). Birds aged from 20 to 30 weeks presented joint lesions. Morbidity ranged between 5 and 10%. Routine postmortem examination of 30 birds revealed a range of visible joint lesions, typically unilateral in distribution. After postmortem examination, samples of tendons, heart and liver were collected for histopathology, bacteriological culture and polymerase chain reaction analysis. Microscopic examination of the tendons revealed changes consistent with a reovirus infection and, to the authors' knowledge, these are the first reported cases of viral arthritis in broiler breeders in Portugal.
Immunocytochemical basis for a meningeo-glial network (2000)

Evidence is presented here for a cellular network that courses through all layers of meninges, the vasculature of both the brain and meninges, and extends into the brain parenchyma. Confocal mapping of calcium-binding protein S100beta immunoreactivity (S100beta-ir) and of the intermediate filament vimentin-ir through serial sections of the meningeal-intact adult rat brain revealed this network. In all tissues examined, S100beta-ir and vimentin-ir were primarily colocalized, and were found in cells with elongated processes through which these cells contacted one another to form a network. The location of labeling and the morphology of the cells labeled were consistent with the possibility that this network consists of fibroblasts in the meninges and the walls of large blood vessels, of pericytes at the level of capillaries, and of ependymocytes and a population of astrocytes in the brain parenchyma. At many sites along the borders of the brain parenchyma itself and of the brain blood vessels, it was possible to detect S100beta-ir and vimentin-ir cell processes that cross the basal laminae. This suggested the probable means by which the S100beta-ir cells of the extraparenchymal tissues anatomically contact the cells that express the same markers in the brain. Privileged anatomical relationships of the S100beta/vimentin network with the glial fibrillary acidic protein (GFAP) astrocytes further suggested that, together, they form the structural basis for a general meningeo-glial network. This organization challenges the current model of brain architecture, calls for a reconsideration of the role of meninges and vascular tissues, and appears to reflect the existence of hitherto unsuspected systems of communication.
Improvement of resistive memory switching in NiO using IrO2 (2006)

For the development of resistive memory devices using NiO, improvements of several memory switching properties are required. In NiO memory cells with noble metal electrodes, broad dispersions of memory switching parameters are generally observed with continuous memory switchings. We report the improvements in minimizing the dispersions of all memory switching parameters using thin IrO2 layers between NiO and electrodes. The role of thin IrO2 layers on NiO growth and memory switching stabilization are discussed.
Recognition, Understanding and Aestheticization of Freehand Drawing Flowcharts (2007)

In this paper a concept of FCA, a system for recognizing, understanding and aestheticization of freehand drawing flow charts is described. The system is based on a proposed by the author FlowGram graph grammar describing flow charts drawing. An open format FlowChartML for flow charts description is also proposed. The aestheticization criterion is formulated that allows for automatic beautification of flow charts. First experiments with the FCA system are also described.
Characterization of  LT  ‐ Li x Co1 − y Ni y  O 2 Electrodes for Rechargeable Lithium Cells (1993)

prepared at 400°C with a structure that is intermediate between an ideal lithiated spinel and a layered structure has been investigated as an electrode in rechargeable lithium cells; it delivers a voltage vs. pure lithium that is significantly lower than the voltage provided by its high‐temperature analogue, , (synthesized at 900°C). The rechargeability of cells can be improved by leaching some lithium and a small amount of cobalt from by acid treatment and loading the cells in a charged state. The improvement in electrochemical performance is attributed to the formation of a defect spinel phase in which the lithium ions adopt the tetrahedral A sites and the cobalt and nickel ions the B sites of an spinel.
Suicidal Destruction of Cytochrome P-450 During Oxidative Drug Metabolism (1983)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Reducing Generation Uncertainty by Integrating CSP With Wind Power: An Adaptive Robust Optimization-Based Analysis (2015)

The uncertainty of wind power generation brings problems in power system operation, such as requiring more reserves and possible frequency issues. In this paper, we propose an idea of combining concentrating solar power (CSP) plants with wind farms to reduce the overall uncertainty in the joint power output. Taking advantage of the dispatchability of CSP, the uncertainty of joint power generation is expected to decrease. Based on the operational model of CSP plants with thermal storage system, we search for the narrowest but robust bounds of the joint power output with a given uncertainty of the wind power output and solar power availability, and within operational constraints of CSP plants. The problem is formulated as an adaptive robust optimization (RO) problem, containing mixed-integer variables at the second stage. We introduce an algorithm that combines a nested column-and-constraint generation (C-CG) method and an outer approximation (OA) method to solve the problem. The case studies show that robust intervals for the joint power output can be obtained, and the obtained intervals can be significantly narrower than the original intervals of wind power.
High urinary ACE2 concentrations are associated with severity of glucose intolerance and microalbuminuria (2012)

Our data suggest that the urinary ACE2 level is closely associated with T2DM and is an independent risk factor for microalbuminuria.
Conjugation of Hydroxyethyl Starch to Desferrioxamine (DFO) Modulates the Dual Role of DFO in <i>Yersinia enterocolitica</i> Infection (2000)

The iron chelator desferrioxamine (DFO) B is widely used in the therapy of patients with iron overload. As a side effect, DFO may favor the occurrence of fulminant Yersinia infections. Previous work from our laboratory showed that this might be due to a dual role of DFO: growth promotion of the pathogen and immunosuppression of the host. In this study, we sought to determine whether conjugation of DFO to hydroxyethyl starch (HES-DFO) may prevent exacerbation of Yersinia infection in mice. We found HES-DFO to promote neither growth of Yersinia enterocolitica nor mitogen-induced T-cell proliferation and gamma interferon production by T cells in vitro. Nevertheless, in vivo HES-DFO promoted growth of Y. enterocolitica possibly due to cleavage of HES and release of DFO. The pretreatment of mice with DFO resulted in death of all mice 2 to 5 days after application of a normally sublethal inoculum of Y. enterocolitica, while none of the mice pretreated with HES-DFO died within the first 7 days postinfection. However, some of the HES-DFO-treated mice died 8 to 14 days postinfection. Thus, due to the delayed in vivo effect HES-DFO failed to trigger Yersinia-induced septic shock, which accounts for early mortality in DFO-associated septicemia. Moreover, our data suggest that DFO needs to be taken up by host cells in order to exert its immunosuppressive action. These results strongly suggest that HES-DFO might be a favorable drug with fewer side effects than DFO in terms of DFO-promoted fulminant infections.
Differential DNA-protein crosslinking in lymphocytes and liver following chronic drinking water exposure of rats to potassium chromate (1991)

Carcinogenic chromium (VI) compounds are persistent environmental contaminants with potential for human exposure through drinking water. One lesion associated with chromium (VI) exposure is the formation of DNA-protein crosslinks (DPC). In an attempt to develop markers of chromium exposure, the formation of DPC in lymphocytes was investigated. Fisher 344 rats were exposed to K2CrO4 in their drinking water for 3 and 6 weeks at concentrations of 100 and 200 ppm chromium. No DPC could be detected in isolated splenic lymphocytes using the alkaline elution technique or by using a polyclonal antibody to chromate-induced DPC. However, increased complexing of proteins with DNA was demonstrated in liver following 3 weeks of exposure at both 100 and 200 ppm chromium. Intraperitoneal administration of potassium chromate did not induce detectable DPC in lymphocytes; however, an increased association of proteins with isolated DNA was detected in the liver. DPC were also induced in isolated splenic lymphocytes following a 2-hr exposure in vitro to 100 microM K2CrO4 in a salts-glucose medium. Although chromium was detected in blood, liver, and kidney, blood levels were comparatively much lower. A comparison of chromium levels required to induce DPC in lymphocytes in vitro and the amount absorbed orally suggests that the white blood cell chromium levels following oral exposure may be too low to induce measurable DNA-protein crosslinks in lymphocytes.
Review of literature on diseases of the colon and rectum (1964)

Diseases of the Colon & Rectum: February 1964 - Volume 7 - Issue 1 - p 66-72 doi: 10.1007/BF02618008
Metal-catalyzed autoxidation. The unrecognized consequences of metal-hydroperoxide complex formation (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal-catalyzed autoxidation. The unrecognized consequences of metal-hydroperoxide complex formationJ. F. BlackCite this: J. Am. Chem. Soc. 1978, 100, 2, 527–535Publication Date (Print):January 1, 1978Publication History Published online1 May 2002Published inissue 1 January 1978https://pubs.acs.org/doi/10.1021/ja00470a028https://doi.org/10.1021/ja00470a028research-articleACS PublicationsRequest reuse permissionsArticle Views610Altmetric-Citations128LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Control and Coordination of Subcontractors (1998)

The planning stages involved in the control and coordination of subcontractors follows similar stages to those that the main contractor goes through, i.e. pretender, pre-contract and contract planning. The decision making process in respect to subcontractors and their involvement in the project will therefore be dealt with under these headings. Subcontractors' input into the various planning stages is illustrated in Figures 8.1 and 8.2.