gebhart/patrepeval huggingface dataset:
Targeting survivin and p53 in pediatric acute lymphoblastic leukemia (2011)

Despite advances in treatment and outcomes for patients with pediatric acute lymphoblastic leukemia (ALL), there continue to be subsets of patients who are refractory to standard chemotherapy and hematopoietic stem cell transplant. Therefore, novel gene targets for therapy are needed to further advance treatment for this disease. RNA interference technology has identified survivin as a potential therapeutic target. Survivin, a member of the inhibitor of apoptosis (IAP) proteins and chromosome passenger complex, is expressed in hematologic malignancies and overexpressed in relapsed pediatric ALL. Our studies show that survivin is uniformly expressed at high levels in multiple pediatric ALL cell lines. Furthermore, silencing of survivin expression in pediatric ALL cell lines as well as primary leukemic blasts reduces viability of these cells. This includes cell lines derived from patients with relapsed disease featuring cytogenetic anomalies such as t(12;21), Philadelphia chromosome t(9;22), t(1;19) as well as a cell line carrying t(17;19) from a patient with de novo ALL. Furthermore, inhibition of survivin increases p53-dependent apoptosis that can be rescued by inhibition of p53. Finally, a screen of randomly selected primary patient samples confirms that survivin-specific small interfering RNA and survivin-targeted drug, YM155, effectively reduce viability of leukemic blasts.
A General and Efficient Method for the Formylation of Aryl and Heteroaryl Bromides (2005)

The key to the general and efficient palladium-catalyzed formylation of aryl and heteroaryl bromides is the use of the di-1-adamantyl-n-butylphosphane (cataCXium A) as ligand. Low pressure of the synthesis gas and appropriate choice of the base are also important for high yields (up to 99 %) of a broad range of (hetero)aromatic aldehydes at unprecedented low catalyst concentrations (see scheme; TMEDA= N,N,N′,N′-tetramethylethylenediamine).
O niektórych ostatnich rozwiązaniach konstrukcyjnych i metodycznych w geofizyce kopalnianej (1960)

ON SOME RECENT ACHIEVEMENTS IN MINE GEOPHYSICS

Summary
The author describes:
1. J. K. Ovtshinnikov's theory of counting of monoelectrode resistivity (during moving it in bore-hole filled with mud). Monoelectrode contacts with the walls of a bore-hole. Monoelectrode logging can be applied specially in ore prospecting drillings for ore zones differentiation.
2. F. P. Kokesh's and R. B. Blizard's article on Geometrical factors in sonic logging. Author's achievements of geophysical logging of bore-holes by acoustic detector with one ultrasonic emitter and two receivers allow to apply this method in Poland.
3. Recently constricted instruments for measuring of curvature of bore hole in the light of W. W. Shitikhin's
article in „Razwiedka i ochrana niedr No 10, 1958. It is suitable to use in Poland the gyroscopic inclinometer SI-3 measuring of the azimuth of bore-hole deviation in full-string parts. This Soviet made inclinometer could be applied in pipes of more than 100 mm in diameter.
Manufacturing Cycle Time Determination for a Multi-Stage Economic Production Quantity Model (1975)

This paper presents a model which treats the manufacturing cycle time as a function of the lot size in a multi-stage production system. Using this functional relationship to determine the magnitude of the work-in-process inventory, a model is developed to calculate the economic production quantity (EPQ). The model assumes that a uniform lot size is manufactured through several operations, with only one set-up at each stage, and that transportation of sub-batches allows an overlap between operations to reduce the manufacturing cycle time. Constant fixed costs per lot, linear inventory holding costs and a constant and continuous demand of finished products are assumed over an infinite horizon. The lot size is considered “economic” when the sum of the fixed costs per lot and the inventory holding costs of both the work-in-process and finished product inventories is minimized. The model is a valid alternative to the conventional production lot size (ELQ) model which only accounts for the finished product inventory. A cost sensitivity analysis reveals the large potential savings from using the suggested EPQ model instead of the conventional ELQ model in multi-stage production systems.
OPERA (1965)

OPERA Get access Rameau, Jean-Philippe, Zoroastre, ed. By Francoise Gervais. Full score. ( Éditions Françaises de Musique, Paris, 1964.) J. A. W. J. A. W. Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume XLVI, Issue 1, January 1965, Pages 88-b–89, https://doi.org/10.1093/ml/XLVI.1.88-b Published: 01 January 1965
Ultraviolet absorption measurements in single-mode optical glass fibers (1992)

Accurate ultraviolet absorption measurements are reported in telecommunication single-mode optical fibers in the range from 280 to 600 nm (4.4–2.1 eV) using a cutback method. An absorption peak at 325 nm (3.8 eV) and an absorption edge near 290 nm (4.3 eV) are attributed to features seen in preform spectra. We suggest that fiber and preform absorption spectra are generally the same and do not find that there is any dependence in the absorption on the fiber dimensions. The effects of preparation for second harmonic generation on fiber absorption are also discussed.
Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair by Enhancing Nitric Oxide Generation (2009)

These studies support consideration of IGFBP-3 as a novel agent to restore the function of injured vasculature and restore NO generation.
The Spring architecture (2002)

A research approach which challenges several basic assumptions on which most current real-time systems are built is presented. A novel paradigm based on the notion of predictability and on a method for online dynamic guarantee of certain types of deadlines is proposed. The Spring paradigm requires an integrated set of solutions, ranging from design and specification methods and tools, to real-time languages, real-time operating systems, and real-time architectures. An overview of the major ideas of this paradigm is given, and the ramifications of this paradigm for the architecture are explained. In particular, the functional level of the architecture as well as the component level are discussed with respect to the application CPUs, MMUs, floating point coprocessors, DSP chips, other I/O front-end processors, buses, and a specialized scheduling processor. The impact of the Spring paradigm on the development of predictable systems is examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Missense variant pathogenicity predictors generalize well across a range of function‐specific prediction challenges (2017)

The steady advances in machine learning and accumulation of biomedical data have contributed to the development of numerous computational models that assess the impact of missense variants. Different methods, however, operationalize impact differently. Two common tasks in this context are the prediction of the pathogenicity of variants and the prediction of their effects on a protein's function. These are related but distinct problems, and it is unclear whether methods developed for one are optimized for the other. The Critical Assessment of Genome Interpretation (CAGI) experiment provides a means to address this question empirically. To this end, we participated in various protein-specific challenges in CAGI with two objectives in mind. First, to compare the performance of methods in the MutPred family with the state-of-the-art. Second and more importantly, to investigate the applicability of general-purpose pathogenicity predictors to the classification of specific function-altering variants without additional training or calibration. We find that our pathogenicity predictors performed competitively with other methods, outputting score distributions in agreement with experimental outcomes. Overall, we conclude that binary classifiers learned from disease-causing mutations are capable of modeling important aspects of the underlying biology and the alteration of protein function resulting from mutations.
Immediate Early Gene Expression in Experimental Epilepsy (1993)

Neuronal excitation by experimentally induced seizures elicits the rapid induction of a set of genes called immediate early genes (IEGs). The gene products of fos, jun and Krox, multimember gene families that belong to the class of IEGs, participate in a fundamental biological control mechanism, the regulation of gene transcription. IEG encoded proteins act as third messengers in an intracellular signal transduction cascade between neural cell surface receptors, cytoplasmic second messenger systems and specific target genes in the nucleus, a process for which the term 'stimulus transcription coupling' has been given. Almost all types of seizures cause dynamic alterations of IEG expression in neurons of the limbic system, but also in non-limbic areas, such as the cortex, striatum and thalamus. IEG encoded transcription factors are thought to up- or down-regulate effector genes with preferential expression in the central nervous system, including genes for neurotransmitters, growth factors, receptors, synaptic and axonal proteins. If the concept holds true that IEGs act as molecular switches converting epileptic short-term excitation of neurons into alterations of the molecular phenotype, future research may help to explain hitherto unexplained phenomena in epileptogenesis including changes of synaptic efficacy, kindling and sprouting.
Molecular Motions in Low Molar-Mass Alkyl Amides: Models for Molecular Motions in Polyamides (1994)

Sub-melting transitions are well known for normal alkanes fatty acids, biological lipid membranes, and normal alkyl ammonium salts. The transitions are thought to involve crystallographic changes, formation of rotator phases, the onset of conformational disorder, or partial melting of portions of the alkyl residues before collapse of the crystal occurs. Understanding these transitions is fundamental to knowing what gives rise to lipid membrane fluidity or crystal-crystal transitions in commercial thermoplastics. Several techniques used in the analysis of these transitions are variable temperature FT-IR, Raman, DSC, X-ray, and solid-state NMR. Each technique gives a particular piece of evidence leading to a better understanding of molecular-level events
The development of CAD for the sawing of timber. 1st report The method of recognizing knots using the image processing technique. (1987)

In the process of sawing a timber into a square bar, knots directly influence the quality of the square bar. The recognition of knots depends on the operator and he determines the cutting position based on many years of experience. As skilled workers become few and old, and the cost of imported square bars decreases, it is necessary to develop a computer aided design (CAD) for the sawing of timber. In this paper, we propose a method for recognizing knots on the surface of timber (Japanese cypress) using the image processing technique. The wave lengths 625 to 770nm (red) or 900 to 1 000 nm (an infrared) are useful for distinguishing clearly between knots and other parts on the timber surface. The knot can be recognized in the process of thresholding the input image, calculating the marginal distribution, approximating an ellipse, and judging the knot.
Kinetics and mechanism of the formation and reactions of S-nitroso derivatives of some heterocyclic thiones (2001)

Rate and equilibrium measurements have been obtained for the nitrosation (using nitrous acid in dilute acid aqueous solution) of the following thione–thiol nitrogen heterocyclic species and for the decomposition reactions of the formed S-NO+ ions: 4-mercaptopyridine (1), 2-mercaptopyridine 1-oxide (2), 2-mercaptopyrimidine (3) and 2-mercapto-1H-imidazole (4). The nitrosation reactions were all rapid and rate constants were obtained by stopped-flow spectrophotometry. In all cases kinetic analysis showed that the halide ion-catalysed and the uncatalysed reactions occurred at or close to the diffusion-controlled limit and the reactive form of the substrate is its thione form. In some cases at high [nitrous acid] reaction occurred via N2O3 where the rate-limiting step is that of N2O3 formation. Similarly reaction of 1 and 3 in the presence of thiocyanate showed that reaction takes place via rate-limiting formation of ONSCN. All of the nitrosation reactions were somewhat reversible, with large equilibrium constants of 2.0 × 107, ∼4 × 105, 1.7 × 103 and 1.5 × 105 dm6 mol−2 respectively for 1, 2, 3, and 4. All of the S-NO+ ions decomposed rapidly in solution generating the disulfides and nitric oxide. This reaction was monitored only for the S-NO+ derived from 1 and 2 because of stability problems. The deprotonated form of the S-nitroso product from 1 was identified from measurements at pH 7.4 and the pKa value of the protonated form estimated as 4.5. It decomposed fairly rapidly to give the thione. We report some results where thiones show considerable catalytic activity in nitrosation reactions of N-methylaniline and ascorbic acid.
Sterically hindered chalcogenolato complexes. Mono- and di-meric thiolates and selenolates of zinc and cadmium; structure of [{Cd(SeC<sub>6</sub>H<sub>2</sub>Bu<sup>t</sup><sub>3</sub>-2,4,6)<sub>2</sub>}<sub>2</sub>], the first three-co-ordinate cadmium–selenium complex (1991)

Protolysis of M[N(SiMe3)2]2(M = Zn or Cd) with arenechalcogenols 2,4,6-R3C6H2EH (E = S or Se; R = Me, Pri or But) gives the corresponding chalcogenolato complexes M(EC6H2R3-2,4,6)2 in high yield. Complexes with R = Me form co-ordination polymers which are soluble only in strongly co-ordinating solvents. An adduct [Cd(SC6H2Me3-2,4,6)2(py)2] can be isolated which dissociates in vacuo with quantitative loss of pyridine (py). Complexes with R = Pri readily dissolve in poorly co-ordinating solvents in which they form oligomers. NMR, infrared and Raman evidence suggests that the sterically more hindered tris-tert-butylbenzenechalcogenolato complexes of zinc and cadmium are dimeric in the solid state but dissociate in hydrocarbon solution to give two-co-ordinate monomers. The compound Zn(SeC6H2But3-2,4,6)2 forms a 1:1 adduct with tetrahydrofuran. The structure of [{Cd(SeC6H2But3-2,4,6)2}2] was determined by X-ray diffraction. The molecule is an asymmetrically bridged dimer, with three-co-ordinate cadmium in a distorted trigonal-planar arrangement. The Cd–Se distances are ca. 0.1 Å shorter than in comparable four-co-ordinate complexes.
Antioxidant defense in children with chronic viral hepatitis B and C. (2001)

Our data suggest the possibility of insufficiency of antioxidant barrier in children with chronic viral hepatitis.
Optimal pumping of erbium-doped-fibre optical amplifiers (1988)

By choosing pump wavelengths which avoid excited-state absorption, efficient, high-gain, erbium-doped fibre amplifiers are possible. Practical pump wavelengths of 532nm and 980nm are identified as optimal, the latter giving a gain as high as 2.2dB/mW of pump.
Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites (2002)

The current pathogenic theory of spontaneous bacterial peritonitis (SBP) in patients with cirrhosis and ascites suggests that repeated episodes of bacterial translocation (BT) from intestinal lumen to mesenteric lymph nodes followed by systemic seeding are the key steps for the final development of infectious events. However, most of the episodes of systemic bacterial circulation remain undetected. Therefore, we investigated the hypothetical presence of bacteria in blood and/or ascitic fluid (AF) from patients with cirrhosis and sterile (culture negative) AF by means of bacterial DNA (bactDNA) detection and identification. Twenty-eight consecutively admitted patients with cirrhosis and presence of AF were included in the study. BactDNA was detected using a polymerase chain reaction (PCR)-based method. The corresponding bacteria were identified by nucleotide sequencing of purified PCR products. BactDNA was detected simultaneously in blood and AF in 9 patients (32.1%). DNA sequencing allowed the identification of Escherichia coli (n = 7) and Staphylococcus aureus (n = 2). In all cases, the similarity between the sequence found in AF and blood indicated that the bactDNA present in both locations originated from a single clone (single translocation event). Child-Pugh score and basic hemodynamic, clinical, endoscopic, and biochemical characteristics were similar among patients with or without the presence of bactDNA. In conclusion, we have detected bactDNA in serum and AF in 32% of all patients studied, and this likely represents single clone episodes of translocation and systemic seeding. E. coli is the most frequently identified bacteria.
Electron Microscopic Evidence of Bacilliform Virus Infection in Kuruma Shrimp(Penaeus japonicus). (1994)

Beginning in the spring of 1993, a serious mortality among cultured kuruma shrimp, Penaeus japonicus occurred in Japan. The typical sign of this disease was white spots on the inside surface of the carapace. Challenge tests demonstrated that the causative agent was highly virulent. This was demonstrated by injection of a filtrered homogenate of the lymphoid organ obtained from diseased shrimp. A non-occluded bacilliform virus was found by electron microscopy in the lymphoid organ of both naturally and experimentally infected shrimps. The virion was bacilliform and surrounded by a virion envelope (a lipid bilayer membrane). The dimension of the virion was 83 nm in diameter and 275 nm in length. From these results, the bacilliform virus is considered to be the causative agent of the disease.
2‐Cyclohexyloxyethanol (2003)

Abstract 2‐Cyclohexyloxyethanol intermediate: 1,4‐Dioxaspiro[4.5]decane product: 2‐Cyclohexyloxyethanol
An object-based audio rendering system using spatial parameters (2012)

In this paper, we propose an object-based audio rendering system, in which the audio signal of each object is distributed to multi-channel systems by spatial parameters. The operation of the rendering system is based on the sound localization theories with the Parametric Stereo (PS) coding structure. The performance of the audio surround effect of a sound moving object is evaluated by subjective listening tests. The experimental result clearly shows that the proposed system is capable of delivering sound moving effect to listeners.
Nature of the Potential Energy Surfaces for the S<sub>N</sub>1 Reaction:  A Picosecond Kinetic Study of Homolysis and Heterolysis for Diphenylmethyl Chlorides (1996)

The picosecond dynamics for the photoinduced homolysis and heterolysis of (4-methylphenyl)phenylmethyl chloride and bis(4-methylphenyl)methyl chloride in acetonitrile are examined. In less than 20 ps, both the geminate radical pair and contact ion pair are formed from the first excited singlet state. The geminate radical pair decays by either diffusional separation to free radicals or electron transfer back to the ground state surface which partitions between reactant and contact ion pair. The contact ion pair decays by diffusional separation to the solvent separated ion pair or by collapse to form the carbon−chlorine bond. The kinetics for these processes are employed in the development of the potential energy surfaces for the SN1 reaction for diphenylmethyl chlorides in polar solvents.
Preparation of Alumina‐Zirconia Powders by Evaporative Decomposition of Solutions (1984)

Fine‐grained, homogeneously dispersed alumina‐zirconia and zirconia powders were prepared by evaporative decomposition of solutions. The pure metastable tetragonal zirconia powder transformed to the monoclinic form when it was heated to 1150°C. The zirconia in the alumina‐zirconia powder, which was also in the tetragonal form, did not transform when the powder was heated to 1150° C. This result is explained in terms of inhibition of coarsening of the zirconia grains by the alumina particles.
Routability of Network Topologies in FPGAs (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A fundamental difference between application-specific integrated circuits (ASICs) and field-programmable gate arrays (FPGAs) is that the wires in ASICs are designed to match the requirements of a particular design. Conversely, in an FPGA, the area is fixed and the routing resources exist whether or not they are used. In this paper, we investigate how well several common network topologies map onto a modern FPGA routing fabric. Different multiprocessor network topologies with between 8 and 64 nodes are mapped to a single large FPGA. Except for the fully-connected networks, it is observed that the difference in logic resources used and routing overhead among these topologies is insignificant for the systems tested. Fully-connected networks up to about 22 nodes are also feasible on the same FPGA although the logic and routing utilization clearly grows much faster. The conclusion is that a modern FPGA fabric is very rich in resources and capable of supporting highly interconnected topologies. For systems with a modest number of nodes implemented on current large FPGAs, it is not necessary to use the connectivity-limited topologies typically used for networks-on-chip. Rather, direct point-to-point connections between all communicating nodes can be considered. </para>
Das Solvosystem Phosphoroxychlorid. III. Verbindungen des Phosphoroxychlorids und das Verhalten ihrer Lösungen (1952)

Abstract Die wasserfreien Halogenide Aluminiumchlorid, Aluminiumbromid, Aluminiumjodid, Antimonpentachlorid, Zinntetrachlorid, Titantetrachlorid und Tellurtetrachlorid bilden mit Phosphoroxychlorid feste Solvate. Diese werden allgemein durch Lösen der betreffenden Halogenide in wasserfreiem Phosphoroxychlorid und Entfernen des überschüssigen Lösungsmittels im Vakuum erhalten. Ihre Lösungen in Phosphoroxychlorid sind elektrolytisch dissoziiert. Die Unterschiede des Verhaltens frisch zubereiteter Lösungen der Halogenide und derjenigen der Solvate werden beschrieben, auf ihre Eigenschaften wird hingewiesen. Es werden Leitfähigkeitsmessungen an Lösungen von Halogeniden in Phosphoroxychlorid beschrieben, die mit dem Solvens nicht zur Bildung fester Solvate befähigt sind und ihre Ergebnisse diskutiert.
Blind estimation of output labels of SIMO channels based on a novel clustering algorithm (1998)

This paper addresses the problem of data detection for digital communications employing space diversity reception, where the system model contains a single-input multiple-output (SIMO) vector channel. The received vector corrupted by additive white Gaussian noise (AWGN) is modeled as the noisy output of a finite state vector Markov source. Subsequently, a discretely valued basis of minimal dimensionality is identified for the input space. Estimation of the output labels associated with this basis allows labeling of the state transition diagram. For this purpose, certain identifiable characteristics of the output sequences of the Markov source are used to classify its states and generate an initial codebook for a vector quantizer used to restore the output level.