gebhart/patrepeval huggingface dataset:
Exogenous Acetate Reconstitutes the Enzymic Activity of Trypsin Asp189Ser (1994)

The specificity of trypsin for Arg- and Lys-containing substrates depends upon the presence of Asp189 at the base of the primary binding pocket. The crystal structure of anionic rat trypsin D189S complexed with BPTI reveals that removal of the aspartate side chain permits the binding of a well-ordered acetate ion in a similar position. The acetate makes polar interactions with Gly226, Tyr228, and several water molecules and is further accommodated by rotation of the Ser189 side chain out of the binding pocket. The carboxylate group of the acetate anion is oriented toward the substrate in a manner similar to that of Asp189 and Asp226 in wild-type trypsin and trypsin D189G/G226D. Evaluation of kinetic parameters for amide substrate cleavage by trypsin D189S shows that high concentrations of acetate increase the catalytic efficiency of the enzyme by as much as 300-fold. Under these conditions, the rate of substrate turnover toward a peptidylarginine amide substrate equals that of wild-type trypsin. These data demonstrate that the well-established requirement for a negatively charged moiety at the base of the trypsin specificity pocket may be fulfilled by a noncovalently bound ligand. The binding pocket of this variant maintains a trypsin-like conformation, explaining the inability of the mutant enzyme to efficiently hydrolyze chymotrypsin substrates possessing Phe in the P1 position.
IS GUTTACORE MORE EASILY REMOVED FROM THE ROOT CANAL THAN THERMAFIL? AN EX-VIVO STUDY. (2015)

GuttaCore is a new cross-linked gutta-percha carrier. Its handling time and ease of removal were compared with those of a plastic carrier (Thermafil) and the continuous wave of condensation technique (control). Forty-five maxillary central incisors were randomly divided 3 groups according to filling technique and retreatment was carried out in all samples with NiTi rotary files, hand files and ultrasonic inserts. Time required for filling removal was recorded. Roots were then split longitudinally and photographed under 5x magnification, and residual filling material was quantified. Removal time was significantly longer for Thermafil (7.10 minutes) than GuttaCore (2.91 minutes) and the control group (1.93 minutes) (p < 0.001). The amount of residual filling material did not differ among the groups: Thermafil 8.31%, GuttaCore 6.27 and control 8.68% (p > 0.05). In conclusion, replacing plastic core with cross-linked gutta-percha allows easier removal of carrier from the root canal. The remnants of filling material in all samples illustrate that retreatment remains a challenge in endodontics.
Production of Nanocrystalline (Fe, Co)-Si-B-P-Cu Alloy with Excellent Soft Magnetic Properties for Commercial Applications (2014)

With the aim of applying to a magnetic core material, the effect of ribbon thickness on the magnetic properties of a (Fe, Co)-Si-B-P-Cu alloy ribbon was investigated.It is found that the Si addition in (Fe, Co)-Si-B-P-Cu nanocrystalline alloy increased the saturation magnetic flux density (B s ), but degraded the coercivity (H c ), suggesting that the Si addition should be suppressed to a little amount.It is also found that the replacement of Fe with Co is quite effective for obtaining better magnetic properties of Fe-Si-B-P-Cu alloy.Even for the thicker ribbons exceeding 30 µm in thickness, the nanocrystalline Fe 81.2 Co 4 Si 0.5 B 9.5 P 4 Cu 0.8 alloy exhibited low H c of 7 A/m and high B s of 1.84 T. Such excellent magnetic properties were successfully reproduced in 50 mm wide ribbons.This regards that the nanocrystallized Co-containing alloy has high applicability to high-efficiency magnetic core material.
Improved ESD protection by combining InGaN-GaN MQW LEDs with GaN Schottky diodes (2003)

GaN Schottky diodes were built internally inside the GaN green LEDs by using etching and redeposition techniques. By properly selecting the etching areas underneath the bonding pads, one can minimize the optical loss due to the etching process. Although the reverse current and the forward turn-on voltage were both higher for the GaN LED with a Schottky diode, it was found that the internal Schottky diode could significantly increase the electrostatic discharge threshold from 450 to 1300 V.
[Diagnostic and treatment results in small-cell lung cancer detected during dispensary care]. (1989)

The study was concerned with evaluating diagnosis and treatment for small-cell cancer of the lung in 75 patients who had been followed up for long periods of time before tumor detection. Methods of monitoring healthy populations as well as those at risk for lung cancer are discussed. Small-cell carcinoma was identified in 18.1%. Prophylactic fluorography of the chest conducted once a year was shown to fail to assure timely identification of small-cell cancer of the lung in most patients. An extra yearly X-ray examination of those at risk was followed by a rise in the percentage of actively--identifiable small-cell lung tumors to 66.7 while tumors detected on presentation--to 25%. Survival in small-cell lung cancer patients was studied and its median was established at 22 months in stage I--II patients given specialized antitumor treatment, 16 months in stage III and 7 months in stage IV.
Biological functions of the low and high molecular weight protein isoforms of fibroblast growth factor‐2 in cardiovascular development and disease (2008)

Fibroblast growth factor 2 (FGF2) consists of multiple protein isoforms (low molecular weight, LMW, and high molecular weight, HMW) produced by alternative translation from the Fgf2 gene. These protein isoforms are localized to different cellular compartments, indicating unique biological activity. FGF2 isoforms in the heart have distinct roles in many pathological circumstances in the heart including cardiac hypertrophy, ischemia-reperfusion injury, and atherosclerosis. These studies suggest distinct biological activities of FGF2 LMW and HMW isoforms both in vitro and in vivo. Yet, due to the limitations that only the recombinant FGF2 LMW isoform is readily available and that the FGF2 antibody is nonspecific with regards to its isoforms, much remains to be determined regarding the role(s) of the FGF2 LMW and HMW isoforms in cellular behavior and in cardiovascular development and pathophysiology. This review summarizes the activities of LMW and HMW isoforms of FGF2 in cardiovascular development and disease.
Contrast Enhancement of Radiographs Using Shift Invariant Wavelet Transform (2000)

用移动的一条新奇途径不变的小浪变换为拍的对比改进被介绍。由在小浪系数之中利用跨规模的关联， X 光线照相术的图象的边信息被提取并且保护，当噪音在小浪域被抚平时。拍然后从非线性的改进操作员在 multi-scales 修改的变换系数被重建。方法能有效地完成对比改进并且同时的保存边的降噪，还给视觉上不同的图象并且在医药诊断提供可观的好处有能力。
Production and Immunological Characterization for Anti Hemin Monoclonal Antibody (1993)

Abstract By using three kinds of antigens for immunization, screening and confirmation, a monoclonal antibody for hemin was produced. The probability of the antibody secreting fused cells was extremely low compared with the normal cell fusion. The antibody could also react some other metal substituted protoporphyrins such as Mn, Pd, Zn and Ga instead of Fe. The monoclonal antibody may loosely recognize the porphyrin ring unlike hemoglobin.
Design and Verification of High-Performance Parallel Processor Hardware for JPEG Encoder (2011)

As the use of mobile multimedia devices is increasing in the recent year, the needs for high-performance multimedia processors are increasing. In this regard, we propose a SIMD (Single Instruction Multiple Data) based parallel processor that supports high-performance multimedia applications with low energy consumption. The proposed parallel processor consists of 16 processing elements(PEs) and operates on a 3-stage pipelining. Experimental results for the JPEG encoding algorithm indicate that the proposed parallel processor outperforms conventional parallel processors in terms of performance and energy efficiency. In addition, the proposed parallel processor architecture was developed and verified with verilog HDL and a FPGA prototype system.
Jointly optimal routing and scheduling in packet ratio networks (1992)

A multihop packet radio network is considered with a single traffic class and given end-to-end transmission requirements. A transmission schedule specifies at each time instant the set of links which are allowed to transmit. The purpose of a schedule is to prevent interference among transmissions from neighboring links. Given amounts of information are residing initially at a subset of the network nodes and must be delivered to a prespecified set of destination nodes. The transmission schedule that evacuates the network in minimum time is specified. The decomposition of the problem into a pure routing and a pure scheduling problem is crucial for the characterization of the optimal transmission schedule.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Gelatin Use Impairs Platelet Adhesion during Cardiac Surgery (1995)

Artificial colloids based on gelatin are used as plasma expander to replace donor blood products. In laboratory experiments, gelatin reduced both the velocity and extend of platelet agglutination by ristocetin, and only the agglutination velocity by polybrene (p < 0.05). Furthermore, gelatin delayed the in-vitro platelet plug formation under shear-stress in the absence of ADP (p < 0.05), whereas gelatin induced no delay in the presence of ADP. Thus, after induction of vWF release from platelets by polybrene or ADP, platelet function was normal. These results indicate that gelatin affects in particular the functionality of plasma-vWF and partly inhibits platelet adhesion. These negative effects of gelatin on hemostasis were demonstrated in two clinical studies during cardiac surgery. In a randomized study of sixty patients undergoing cardiac surgery, gelatin as prime in the heart-lung machine appeared to result in diminished efficacy of aprotinin on hemostasis, whereas it did not affect hemostasis in non-aprotinin patients. An additional retrospective clinical study showed that only high dose of gelatin affected hemostasis. This suggests a limited role of plasma-vWF and a strong back-up mechanism of platelet-vWF in achieving hemostasis.
3D Voxel-Based Volumetric Image Registration with Volume-View Guidance (2005)

In this article, we will present a novel interactive image registration technique using the 3D volumetric view as guidance throughout the registration process. The registration criterion used in this technique is the homogeneity of the color distribution on any given anatomic landmark, usually the skin/muscle voxels. This registration criterion has been validated using two different approaches, including comparison with automatic registration using mutual information based on the Insight Toolkits (ITK) and comparison with registered MR images with different pulse sequences acquired directly from the same MR scanner less than 5 minutes. An investigation is also made to compare this technique with the conventional interactive image registration using three orthogonal planar (3P) views, which is predominantly used in the current treatment planning in clinic. This 3D technique has shown several advantages, including improved registration accuracy and accelerated registration speed. It has also found that the 3P pixel registration technique often “inherits” a global positioning error, due to its partial 3D visual presentation. In addition, unlike the 3P technique, which generally cannot be used to register more than 2 images simultaneously and low resolution PET images, this 3D technique can register up to 4 imaging modalities simultaneously, including PET images, with both global view guidance and detail checking capability.
Recent Advances in Understanding the Malnutrition‐Inflammation‐Cachexia Syndrome in Chronic Kidney Disease Patients: What is Next? (2005)

Several recent clinical trials using single modalities to correct the conventional cardiovascular risk factors in patients with chronic kidney disease (CKD) or to improve dialysis dose and techniques in maintenance dialysis patients have failed despite the high rate of cardiovascular mortality in these individuals. Protein-energy malnutrition and inflammation, two relatively common and concurrent conditions in CKD patients, have been implicated as the main cause of poor short-term survival in this population. The "malnutrition-inflammation-cachexia syndrome" (MICS) appears to be the main cause of worsening atherosclerotic cardiovascular disease in the CKD population. The MICS is associated with low serum cholesterol and homocysteine levels and leads to "cachexia in slow motion." Hence a reverse epidemiology of cardiovascular risk factors is observed in dialysis patients with a paradoxical association of obesity, hypercholesterolemia, and hyperhomocysteinemia with better survival. Correction of MICS can potentially ameliorate the cardiovascular epidemic in CKD patients. Because MICS is multifactorial, its correction will require an integral approach rather than a single intervention. The ongoing obsession with conventional cardiovascular risk factors largely reflecting overnutrition in a population that suffers from the short-term consequences of undernutrition and excessive inflammation may well be fruitless. Clinical trials focusing on the causes and consequences of MICS and its modulation using nutritional interventions may be the key to improving survival in these individuals.
GaAs HBT power amplifier with smooth gain control characteristics (2002)

A gain control scheme giving simultaneously an effective power switch-off operation and smooth gain control characteristics is presented. The concept was applied to a 3-stage power amplifier which was a part of a 900-MHz transmitter chip. The chip was realised by using GaAs MMIC technology and was mounted on a ceramic substrate. The power amplifier was tested separately by mounting it directly on a conventional FR4 board. In this lossy environment the power amplifier delivered an output power of 33.2 dBm with a supply voltage of 3.5 V. The maximum value of the gain control slope was 22 V/V showing a good agreement to the simulations.
I.V. fluids What nurses need to know (2011)

In Brief Refresh your knowledge about I.V. fluids, including how they act in the body and which ones to use (or avoid) in common clinical situations. This is the first in a series of articles on fluid and electrolyte balance.
Welfare Evaluations in Contingent Valuation Experiments with Discrete Responses (1984)

Abstract Since the work of Bishop and Heberlein, a number of contingent valuation experiments have appeared involving discrete responses which are analyzed by logit or similar techniques. This paper addresses the issues of how the logit models should be formulated to be consistent with the hypothesis of utility maximization and how measures of compensating and equivalent surplus should be derived from the fitted models. Two distinct types of welfare measures are introduced and then estimated from Bishop and Heberlein's data.
Autologous chondrocyte transplantation for reconstruction of isolated joint defects: the Assaf Harofeh experience. (2000)

Chondrocyte implantation is a procedure capable of restoring normal articular cartilage in cases with isolated joint defects. Pain can be predictably reduced, while joint locking and effusion are eliminated. The effect on osteoarthritis progression in humans has not yet been elucidated.
An Efficient Semianalytic Reservoir Model for Complex Reservoirs (1993)

Abstract This paper presents a summary of the development of a semi-analytic reservoir model for gas reservoirs with various reservoir complexities. The types of reservoir complexities that have been considered in this study include; multiple reservoir layers in which the reservoir layers may be infinite or finite in extent, dual or single porosity systems, and wells that have been fractured. The reservoir model that has been developed and used in this study was constructed with the appropriate Laplace domain pressure and rate-transient solutions that are available in well testing literature. This reservoir model was developed to provide a more detailed and accurate means of analyzing or predicting the performance of a gas reservoir than is possible with a simple "type Curve" approach, yet would be more computationally efficient than a finite difference reservoir model. The results of the semi-analytic reservoir model have been validated with the reference solutions generated with a commercial finite difference reservoir simulator. The results of the semi-analytic reservoir model are comparable to the results of the finite difference simulator, yet require substantially less computation time and computer memory.
Granular and jammed materials (2010)

A graphical abstract is available for this content
Formation of H<sub>2</sub> and H<sub>2</sub>O<sub>2</sub> in a Water-Spray Gliding Arc Nonthermal Plasma Reactor (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionFormation of H2 and H2O2 in a Water-Spray Gliding Arc Nonthermal Plasma ReactorR. Burlica, K.-Y. Shih, and B. R. Locke*Cite this: Ind. Eng. Chem. Res. 2013, 52, 37, 13516Publication Date (Web):September 9, 2013Publication History Published online9 September 2013Published inissue 18 September 2013https://pubs.acs.org/doi/10.1021/ie402767fhttps://doi.org/10.1021/ie402767fcorrectionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views651Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (114 KB) Get e-Alertsclose Get e-Alerts
<title>Parallel confocal systems for biomedical application</title> (2001)

A parallel confocal method including an optical diffractive element, a Dammann grating, is presented. Dammann gratings manufactured with microfabrication technologies have the ability to generate several beams with identical intensity. An optical confocal system combining with a Dammann grating will form multi-channel confocal optical structures, so that it can achieve a planar image instantly without scanning. This parallel confocal fluorescence detection system has the merits of discarding scanning part, compact structure, real time imaging and detection and high S/N ratio, therefore it is suitable for detection of dye-labelled DNA array chips and for other biomedical applications. Structural considerations and design of a parallel confocal fluorescence setup and experimental results of detecting a dye-labeled DNA array chip are presented in this paper.
Deep Learning for Fall Detection: Three-Dimensional CNN Combined With LSTM on Video Kinematic Data (2018)

Fall detection is an important public healthcare problem. Timely detection could enable instant delivery of medical service to the injured. A popular nonintrusive solution for fall detection is based on videos obtained through ambient camera, and the corresponding methods usually require a large dataset to train a classifier and are inclined to be influenced by the image quality. However, it is hard to collect fall data and instead simulated falls are recorded to construct the training dataset, which is restricted to limited quantity. To address these problems, a three-dimensional convolutional neural network (3-D CNN) based method for fall detection is developed, which only uses video kinematic data to train an automatic feature extractor and could circumvent the requirement for large fall dataset of deep learning solution. 2-D CNN could only encode spatial information, and the employed 3-D convolution could extract motion feature from temporal sequence, which is important for fall detection. To further locate the region of interest in each frame, a long short-term memory (LSTM) based spatial visual attention scheme is incorporated. Sports dataset Sports-1 M with no fall examples is employed to train the 3-D CNN, which is then combined with LSTM to train a classifier with fall dataset. Experiments have verified the proposed scheme on fall detection benchmark with high accuracy as 100%. Superior performance has also been obtained on other activity databases.
The Economic Ethics of John Wesley By Kathleen Walker MacArthur. New York: Abingdon Press, 1936. 166 pages. $1.50. (1937)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Intuitive and Adaptive Robotic Arm Manipulation using the Leap Motion Controller (2014)

Robotics provide an efficient approach in the development of assistive devices, due to their enhanced functionality. Statistics predict that by 2035, half of the population in Germany is going to be older than fifty, every third person even over 60. These ageing societies face numerous challenges in performing simple tasks in Activities of Daily Living “ADLs”. Increasingly, a lot of research is being focused on Ambient Assisted Living “AAL” which presents a new approach that promises to address the needs of elderly people. An important goal of AAL is to contribute to the quality of life of the elderly and handicapped people and help them to maintain an independent lifestyle. The introduction of robotics and technology-supported environments will play a huge role in allowing elderly and physically impaired people to keep living a self-determined, independent life in their familiar surroundings. In this paper, the implementation of a novel intuitive and adaptive manipulation scheme is proposed, by developing a human-machine communication interface between the Leap Motion controller and the 6-DOF Jaco robotic arm. An algorithm is developed to allow an optimum mapping between the user hand movement, tracked by the Leap Motion controller, and the Jaco arm. The system should allow for a more natural human-computer interaction and a smooth manipulation of the robotic arm, by constantly adapting to the user hand tremor or shake. The implementation would specially enhance the quality of living, especially for people with upper limb problems, and would support them in performing some of the essential Activities of Daily Living “ADLs”. The applications of this human-robot interaction will be discussed in relation with Ambient Assisted Living, where some use case scenarios will be introduced.
Detecting Nanoscale Size Dependence in VO<sub>2</sub> Phase Transition Using a Split-Ring Resonator Metamaterial (2011)

We have measured the size dependence of a solid-solid phase transformation in discrete nanoscale volumes of vanadium dioxide (VO(2)) defined by split-ring resonators. By monitoring the in-coupling plasmonic mode while thermally cycling through the insulator-metal transition, we show that hysteresis width broadens with reduced interrogation volume (i.e., number of intrinsic nucleation sites). The results further imply a volume range over which both electronic and structural components of the switching exhibit similar size dependence.