gebhart/patrepeval huggingface dataset:
Studies of Sites of Action of a New Plant Growth Retardant (E)-1-(4-Chlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-1-penten-3-ol (S-3307) and Comparative Effects of Its Stereoisomers in a Cell-Free System from <italic>Cucurbita maxima</italic> (1985)

(E)-1-(4-Chlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-1-penten-3-ol (S-3307), a new plant growth retardant, was investigated to determine the inhibitory sites in gibberellin biosynthesis and the comparative effects of its stereoisomers in a cell-free system from Cucurbita maxima. After treatment with S-3307, the incorporation of [14C]mevalonic acid into GA12-aldehyde and GA12 clearly was inhibited, and kaurene accumulated. Feeding experiments showed that S-3307 inhibited the oxidation of kaurene, kaurenol and kaurenal, but did not affect the oxidation of kaurenoic acid. Thus the reaction sites of S-3307 in gibberellin biosynthesis were shown to be the three oxidation steps from kaurene to kaurenoic acid. Because S-3307 has an asymmetric center and a tri-substituted double bond, there are four stereoisomers; two optical isomers and two geometrical isomers. The activities of these isomers as a growth retardant and gibberellin biosynthesis inhibitor were examined with a rice seedling assay and the cell-free system. The relative activity of these isomers was basically the same in the two assay methods. The (S)-(E) form was the most active, being 7-fold more active in the cell-free system and 70-fold more active in the bioassay than the (R)-(E) form. The (RS)-(Z) form showed no activity in the cell-free system, but weak dwarfing effects in the rice seedling assay.
Simulation-guided lyapunov analysis for hybrid dynamical systems (2014)

Lyapunov functions are used to prove stability and to obtain performance bounds on system behaviors for nonlinear and hybrid dynamical systems, but discovering Lyapunov functions is a difficult task in general. We present a technique for discovering Lyapunov functions and barrier certificates for nonlinear and hybrid dynamical systems using a search-based approach. Our approach uses concrete executions, such as those obtained through simulation, to formulate a series of linear programming (LP) optimization problems; the solution to each LP creates a candidate Lyapunov function. Intermediate candidates are iteratively improved using a global optimizer guided by the Lie derivative of the candidate Lyapunov function. The analysis is refined using counterexamples from a Satisfiability Modulo Theories (SMT) solver. When no counterexamples are found, the soundness of the analysis is verified using an arithmetic solver. The technique can be applied to a broad class of nonlinear dynamical systems, including hybrid systems and systems with polynomial and even transcendental dynamics. We present several examples illustrating the efficacy of the technique, including two automotive powertrain control examples.
On Electrochemical Deposition for Layered Manufacturing (2004)

This paper describes the initial results from new research in the area of electrochemical deposition applied to rapid layered manufacturing with heterogeneous materials. Our interest in electrochemical layered manufacturing stems from earlier collaborative projects on heterogeneous modeling and fabrication [1–4]. The current work focuses on employing electrochemical deposition of binder into layers sequentially added to a powder bed as a method for additive fabrication of working parts. We show that electrodeposition provides a feasible approach to (1) eliminating the need for a fugitive binder system, (2) reducing thermal postprocessing operations for three-dimensional printing of working parts, and (3) achieving a room temperature fabrication process minimizing the need for thermal postprocessing thereby eliminating residual thermal stresses and dimensional inaccuracies from thermal expansion/contraction associated with processing at elevated temperatures. We also demonstrate the feasibility of direct, single-step fabrication of fully dense parts.
Adduct of C70 at the Equatorial Belt: Photochemical Cycloaddition with Disilirane (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdduct of C70 at the Equatorial Belt: Photochemical Cycloaddition with DisiliraneTakeshi Akasaka, Eiko Mitsuhida, Wataru Ando, Kaoru Kobayashi, and Shigeru NagaseCite this: J. Am. Chem. Soc. 1994, 116, 6, 2627–2628Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/ja00085a056https://doi.org/10.1021/ja00085a056research-articleACS PublicationsRequest reuse permissionsArticle Views192Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Dissolution of cellulose in ionic liquid: A review (2017)

Dissolution of cellulose with ionic liquids (IL) and deep eutectic solvent (DES) lets the comprehensive dissolution of cellulose. Basically, cellulose can be dissolved, in some hydrophilic ionic liquids, such as 1-butyl-3-methylimidazolium chloride (BMIMCl) and 1-allyl-3-methylimidazolium chloride (AMIMCl). Chloride based ionic liquids are suitable solvents for cellulose dissolution. Although the ILs is very useful in fine chemical industry, its application in the pharmaceutical and food industry have been very limited due to issues with toxicity, purity, and high cost. Seeing to these limitations, new green alternative solvent which is DES was used. This green solvents, may be definitely treated as the next-generation reagents for more sustainable industrial development. Thus, this review aims to discuss the dissolution of cellulose either with ionic liquids or DES and its application.
Generation of<i>Cre</i>Transgenic Mice with Postnatal RPE-Specific Ocular Expression (2011)

This BEST1-cre transgenic line enables generation of RPE-specific knockout mice. The mosaic expression pattern provides an internal control; the non-cre-expressing RPE cells continue to express the floxed genes. These mice should facilitate study of the multifunctional RPE and the generation of mouse models of human retinal disease.
LDH and fibrinogen-fibrin degradation products in pulmonary embolism (1974)

Serum lactic acid dehydrogenase (LDH) and fibrinogen-fibrin degradation product (FDP-fdp) levels were measured in 35 patients, and LDH isozyme distributions in 11 patients with arteriographically proved pulmonary emboli. Levels of LDH tended to be maximal during the 48 hours following embolization; 30% of those measured during this interval were elevated. Distribution of serum LDH levels in these patients was similar to that in patients with congestive heart failure or pneumonia with effusion. The LDH isozyme patterns of our patients were characterized by increased LDH<sub>3</sub>. However, they were not sufficiently characteristic to differentiate pulmonary embolization from congestive heart failure or pneumonia. The FDP-fdp levels were elevated or borderline in 20%. Single measurements of LDH, LDH isozyme, and FDP-fdp levels, performed when the diagnosis is suspected with these methods, are not reliable tests for pulmonary emboli.
Prediction of Extrusion Failures of O-Ring Seals (1984)

It is generally recommended by most manufacturers to keep working pressures of O-ring seals below 10 MPa (20 MPa with backup rings) and clearances below 0.15 mm, or else they might fail by extrusion. For many applications, and especially for large one-shot impact devices, these limits are much too low, and more realistic limits may be set through better understanding of the failure modes. A theoretical analysis of the O-ring elastic and plastic extrusion process is developed and test results up to 350 MPa are shown to support the analysis. The resulting extrusion fail-loads are examined as function of seal geometry, material properties, and load rates. Some design recommendations and further research efforts are discussed.
Low‐mobility‐pass filter between atmospheric pressure chemical ionization and electrospray ionization sources and a single quadrupole mass spectrometer: computational models and measurements (2013)

The benefit of this concept is that discrimination against ions of high mobility is controlled by only a single parameter: waveform amplitude at fixed frequency. The effective removal of high mobility ions, those of low mass-to-charge, can be beneficial for applications with ion-trap-based mass spectrometers to remove excessive levels of solvent or matrix ions.
Draft Genome Sequence of Rhodococcus triatomae Strain BKS 15-14 (2013)

We report the 5.8-Mb genome sequence of Rhodococcus triatomae BKS 15-14, isolated from an ant hill soil sample, collected from Bhitarkanika Mangrove Reserve Forest, Odisha, India. The draft genome of strain BKS 15-14 consists of 5,824,349 bp, with a G+C content of 69%, 5,387 protein-coding genes, and 57 RNAs.
The Chemical Structure of the Intermediate Metabolites of Catechin I–IV (1959)

Journal Article The Chemical Structure of the Intermediate Metabolites of Catechin I–IV: Chemical Properties of the Intermediate Metabolites (G and H) and their Derivatives Oxidative Decomposition of the Intermediate Metabolites (G and H) Synthesis of the Intermediate Metabolites (G and H) Structure of the Intermediate Metabolite (F) Get access Hiroyasu Watanabe Hiroyasu Watanabe Department of Agricultural Chemistry, Faculty of Agriculture, Kyushu University Present address: Osaka Research Laboratory, Tanabe Seiyaku Co., Ltd.(Kajima-cho, Higashiyodogawa-ku, Osaka) Search for other works by this author on: Oxford Academic Google Scholar Bulletin of the Agricultural Chemical Society of Japan, Volume 23, Issue 4, 1 July 1959, Pages 257–271, https://doi.org/10.1080/03758397.1959.10857572 Published: 01 July 1959 Article history Received: 05 September 1958 Published: 01 July 1959
SOT: secure overlay tree for application layer multicast (2004)

Application layer multicast (ALM) has been proposed to overcome current limitations in IP multicast. We address, for the first time, offering data confidentiality in ALM. To achieve data confidentiality, data encryption keys are shared among the multicast group members. Observe that in this system, a node may need to continuously reencrypt packets before forwarding them downstream. Furthermore, keys have to be changed whenever there is a membership change, leading to rekey processing overhead at the nodes. For a large and dynamic group, these reencryption and rekeying operations incur high processing overhead at the nodes. We introduce a scalable scheme called secure overlay tree (SOT) which clusters ALM peers so as to localize rekeying within a cluster and to limit reencryption at cluster boundaries, thereby minimizing the total nodal processing overhead. We describe the operations of SOT and compare its nodal processing overhead with two other basic approaches, namely, host-to-host encryption and whole group encryption. We show that there exists an optimal cluster size to minimize the total nodal processing overhead. SOT achieves substantial reduction in nodal processing overhead with little cost in network performance in terms of network stress and delay.
Ultrastructural localization of an intracellular Toxoplasma protein that induces protection in mice (1987)

We report the ultrastructural localization of Toxoplasma antigens recognized by monoclonal antibody F3G3, which protects mice against lethal challenge. By using colloidal immunogold labeling, F3G3 failed to react with the surface of intact Toxoplasma cells, confirming previous observations that it recognizes an intracellular antigen. Immunoperoxidase labeling with F3G3 was obtained only when Toxoplasma cells were previously exposed to Triton X-100. A specific immunoperoxidase reaction was located beneath the surface membrane in the region of the pellicle and within the elaborate network of vesicles which are extruded from the surface of Toxoplasma cells during entry into host cells. Similar results were obtained with mouse polyclonal sera and a second monoclonal antibody, 6-86-1E11, both of which were produced against the F3G3 affinity-purified protein. The location of the epitope recognized by F3G3 was confirmed by purifying T. gondii-derived surface membrane vesicles, separating these proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and immunoblotting. Monoclonal antibody 6-86-1E11 and the analogous polyclonal sera reacted with the antigenically related proteins of 58 and 28 kilodaltons that were found both in the intact organisms and in the purified surface membrane vesicles. These results indicate that the epitope recognized by F3G3 is located beneath the Toxoplasma cell surface membrane and is contained within plasma membrane-derived vesicles.
Collagen membranes prevent the apical migration of epithelium during periodontal wound healing (1987)

Collagen membranes were interposed between full thickness periodontal flaps and denuded root surfaces of right upper canines in 3 mongrel dogs; the left canines were sham‐operated without the use of collagen membranes. Animals were killed 10 d after surgery. Tissue blocks were removed, and experimental and control sites were processed for histometric and histologic examination. The results indicate that collagen membranes: (i) prevent apical migration of the epithelium during initial stages of healing; and (ii) are colonized by connective tissue cells and incorporated within the healing connective tissue.
Regulation of free cytosolic Ca2+ concentration in the outer segments of bovine retinal rods by Na-Ca-K exchange measured with fluo-3. I. Efficiency of transport and interactions between cations. (1991)

Regulation of free cytosolic Ca2+ concentration in the rod outer segments (ROS) isolated from bovine retinas was examined with the fluorescent Ca(2+)-indicating dye fluo-3. In situ calibration of cytosolic fluo-3 was done in the presence of the Ca2+ ionophore A23187 and yielded a dissociation constant of 500 nM for the Ca(2+)-fluo-3 complex. Ca2+ influx in Ca(2+)-depleted ROS was completely abolished when internal Na+ was removed suggesting that Ca2+ influx exclusively occurred via Na-Ca-K exchange. The most striking observation was that Na-Ca-K exchange could mediate a rapid increase in cytosolic free Ca2+ over the most of the usable indicating range of fluo-3 (from 10 nM to 2 microM), even when exposed to free external Ca2+ concentrations as low as 10 nM. From a comparison between changes in free Ca2+ and changes in total Ca2+, we conclude that physiologically occurring changes in cytosolic free Ca2+ are mediated by exchange fluxes less than 1% of the maximal Na-Ca-K exchange flux. The Na-Ca-K exchanger could mediate both K(+)-dependent and K(+)-independent Ca2+ influx; Li+ caused a complete inhibition of K(+)-independent Ca2+ influx, but had no effect on K(+)-dependent Ca2+ influx. We examined the complex interactions of alkali cations with Ca2+ influx and discuss the results in terms of a three-site model for the Na-Ca-K exchanger (Schnetkamp, P. P. M. and Szerencsei, R. T. (1991) J. Biol. Chem. 266, 189-197). Ca2+ competed with one Mg2+ ion or two Na+ ions for binding to a common site. High K+ concentration greatly diminished the ability of Na+ and Mg2+ to compete with Ca2+ for this common site on the exchanger protein. As a result, high internal K+ induced a conformation of the exchange protein that kinetically favoured Ca2+ extrusion.
Novel Magnetic Resonance Signal Enhancing Coating Material (2001)

Magnetic resonance (MR) guided endovascular intervention is an attractive guiding technique, but until now it has been difficult to visualize the catheter. Here it is revealed that by chemically attaching a Gd complex to the polyethylene surface of the catheter strong MR signals and a clear contrast between the coated materials and the background can be obtained. The Figure shows one uncoated (d) and three coated (a,b, c) samples.
Forensic memory analysis: Files mapped in memory (2008)

In this paper we describe a method for recovering files mapped in memory and to link mapped-file information process data. This information is forensically interesting, because it helps determine the origin and usage of the file and because it reduces the amount of unidentified data in a memory dump. To find mapped-file content, we apply several different techniques. Together, these techniques can identify approximately 25% of test memory dumps as being part of a memory-mapped file.
Biofiltration: A promising and cost‐effective control technology for Odors, VOCs and air toxics (1997)

Abstract Biofiltration, a relatively recent air pollution control technology, has been identified as a promising method of odor, VOC and air toxic removal form waste‐gas streams because of low capital and operating costs, low energy requirements and an absence of residual products requiring further treatment or disposal. Biofiltration units are microbial systems incorporating microorganisms grown on a porous solid media like compost, peat, soil or mixture of these materials. The filter media and the microbial culture are surrounded by a thin film of water called biofilm. Waste‐gases containing biodegradable VOCs and inorganic air toxics are vented through this biologically active material, where soluble contaminants partition into the liquid film and are biodegraded by the resident microorganisms in the biofilm. The technology has been successfully applied to a wide range of industrial and public sector sources for the abatement of odors, VOCs and air toxics, with an elimination efficiency of more than 90%. Owing to its economic advantage over the conventional air pollution control methods coupled with environmental benefits like low energy requirements and the avoidance of cross‐media transfer of pollutants, biofiltration is becoming more popular and practical in meeting the statutory emission regulations. The study presents an overview of the historical development and present status of biofiltration; summarizes its basic requirements, engineering fundamentals, operating principles, applicability, cost‐effectiveness and potential failures.
Biomembrane structures. Fourier transform infrared spectroscopy and biomembrane technology (1989)

Conference Article| December 01 1989 Biomembrane structures. Fourier transform infrared spectroscopy and biomembrane technology DENNIS CHAPMAN; DENNIS CHAPMAN 1Department of Protein and Molecular Biology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, U.K. Search for other works by this author on: This Site PubMed Google Scholar PARVEZ I. HARIS PARVEZ I. HARIS 1Department of Protein and Molecular Biology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (6): 951–953. https://doi.org/10.1042/bst0170951a Article history Received: June 22 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation DENNIS CHAPMAN, PARVEZ I. HARIS; Biomembrane structures. Fourier transform infrared spectroscopy and biomembrane technology. Biochem Soc Trans 1 December 1989; 17 (6): 951–953. doi: https://doi.org/10.1042/bst0170951a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: PC: phosphorylcholine, DPPC, dipalmitoyl-phosphatidylcholine, DAPC, diacetylenic phosphatidylcholine This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Structural Basis for Ligand Regulation of the Fatty Acid-binding Protein 5, Peroxisome Proliferator-activated Receptor β/δ (FABP5-PPARβ/δ) Signaling Pathway (2014)

Fatty acid-binding proteins (FABPs) are a widely expressed group of calycins that play a well established role in solubilizing cellular fatty acids. Recent studies, however, have recast FABPs as active participants in vital lipid-signaling pathways. FABP5, like its family members, displays a promiscuous ligand binding profile, capable of interacting with numerous long chain fatty acids of varying degrees of saturation. Certain "activating" fatty acids induce the protein's cytoplasmic to nuclear translocation, stimulating PPARβ/δ transactivation; however, the rules that govern this process remain unknown. Using a range of structural and biochemical techniques, we show that both linoleic and arachidonic acid elicit FABP5's translocation by permitting allosteric communication between the ligand-sensing β2 loop and a tertiary nuclear localization signal within the α-helical cap of the protein. Furthermore, we show that more saturated, nonactivating fatty acids inhibit nuclear localization signal formation by destabilizing this activation loop, thus implicating FABP5 specifically in cis-bonded, polyunsaturated fatty acid signaling.
Aztreonam (1995)

Aztreonam is a monocyclic beta-lactam antibiotic that is active exclusively against the aerobic gram-negative bacilli. It is not ototoxic or nephrotoxic and so is used as an alternative to aminoglycosides in a variety of clinical situations. In polymicrobial infections or when used for empiric therapy, aztreonam must be combined with other antimicrobial agents active against gram-positive and anaerobic species. Aztreonam is often effective against resistant strains of gram-negative organisms, which are often involved in nosocomial infections. Overuse of aztreonam should be avoided to prevent the emergence of resistant P. aeruginosa strains. Except in the treatment of P. aeruginosa infections, aztreonam should not be added to beta-lactam regimens for additional gram-negative coverage.
Preparation of calibrating standards for x‐ray fluorescence spectrometry of trace metals in plastics (2003)

Abstract Convenient x‐ray fluorescent spectrometry was developed for the determination of V, Cr, Co, Ni, Ge and Sb in plastic materials. The calibrating standards were prepared by casting of polyurethane or polyester including a xylene solution of organometallic compounds as a standard. The calibrating disk had a homogeneous elemental distribution and excellent durability. The calibration curves of six elements showed a good linearity of less than 50 mass ppm for V and Ni, 100 mass ppm for Co and Ge, 200 mass ppm for Cr, and 400 mass ppm for Sb. The lower limits of detection (3σ) of the present method were 0.19 mass ppm for V, 0.42 for Cr, 0.24 for Co, 0.18 for Ni, 0.066 for Ge, and 2.1 for Sb. The proposed method has been applied to several different industrial plastics. The quantitative results are in good agreement with those obtained by the AAS method and x‐ray fluorescent spectrometry using the fundamental parameter calculation method. Copyright © 2003 John Wiley & Sons, Ltd.