gebhart/patrepeval huggingface dataset:
DETERMINATION OF THE NUMBER OF KANBANS AND BATCH SIZES IN A JIT SUPPLY CHAIN SYSTEM (2010)

Under stochastic demand in the multi-stage SCM in a JIT environment, the probability
of generating a function of the stationary distributions of the backlogged demand was extended. The
batch size of WIPs has a great impact on the packing, unpacking or transferring costs of a chain; it
has been attempted to integrate the delivery batch size of each plant in a multi-stage serial chain with
the production-ordering and supplier kanbans of the chain. An algorithm was developed to evaluate the
optimal numbers of kanbans and batch sizes of each plant by minimizing the total cost of a chain. A
numerical example is also provided to indicate the signicance of adding the proposed assumptions, as
well as demonstrating the approach adopted towards solving the problem.
Synthesis of <scp>L</scp>‐Propargylglycine and Derivatives (1976)

Abstract The chemical synthesis of L ‐propargylglycine ( L ‐Pra) and of various derivatives is described. The new amino acid is a starting material for carboranylalanine (Car) and for tritiated norleucine.
Inorganic metal polymers: preparation and characterization (1995)

It is possible to produce stable preparations of partially neutralized aluminum chloride solutions in which cationic aluminum polyelectrolytes predominate, but attempts to produce similar stable preparations containing cationic iron(III) polyelectrolytes were unsuccessful. One method to improve the effectiveness of inorganic metal coagulants in water treatment is to partially neutralize concentrated metal salt solutions prior to their addition to the raw water and thus preform polymeric metal species, the actual coagulants. In this way coagulant chemistry can be controlled and proper solution conditions for the formation of desired coagulant species can be maintained. This article compares polymeric preparations of aluminum and ferric chloride salts with respect to preparation parameters and the extent and stability of polymerization.
Modelling of a pressure swing adsorption process for oxygen enrichment with carbon molecular sieve (1988)

Abstract Adsorptive separation of oxygen from nitrogen and argon is carried out during the desorption steps of a pressure swing adsorption (PSA) process which uses carbon molecular sieves developed by Bergbau‐Forschung GmbH. The adsorption isotherms of the three main components of air are very similar. On account of the pore size distribution of CMSN2, the diffusion coefficient of oxygen is more than eight times those of nitrogen and argon so that air separation occurs by adsorption kinetics. Experimental results for the individual steps and cyclic operation of the PSA process are presented and compared with the predictions of an isothermal plug‐flow model. Adsorption rate is represented by a linear driving force equation. If the diffusion coefficients are adapted separately to every step, a good agreement is observed between the model calculations and experimental results.
Consecutive Cycles of Precise, Unidirectional 14-bp Deletions Using a <i>Bse</i> RI/ <i>Bsg</i> I Trimming Plasmid (1996)

A straightforward method for generating precise, consecutive, unidirectional 14-bp deletions into cloned DNA, adopted from the trimming principle developed by Szybalski and his colleagues, is presented. The method utilizes pTRIM14, a plasmid constructed with the class-IIS restriction enzyme recognition sites for BseRI and BsgI arranged in the form of a cassette, just upstream from the cloned DNA. Class-IIS restriction enzymes cleave DNA downstream of their recognition sites. pTRIM14, containing the cloned DNA, is processed through a trimming cycle that involves sequential restriction digestions with BsgI and then BseRI, followed by treatment with Mung Bean nuclease and then with ligase. One trimming cycle results in a net 14-bp deletion. We demonstrate precise, consecutive deletions at very high efficiency.
Review: Current knowledge on the role of HPV antibodies after natural infection and vaccination: Implications for monitoring an HPV vaccination programme (2013)

In 2006/2007, two vaccines were licensed against two of the most common HPV types that cause about 70% of cervical cancers. Clinical trials show that vaccinated individuals develop high levels of neutralizing antibodies. Although these data suggest that serum antibodies are the mode of action against HPV infection, it is uncertain whether immune responses generated by vaccination are similar to those induced by a natural infection. In this review, the current knowledge of humoral immune responses after natural infection and vaccination is described. Serosurveillance can be used as a monitoring tool to study vaccine uptake, the impact of HPV16/18 vaccination on other HPV types, dynamics of HPV infection and herd-immunity. In addition, factors that contribute to a higher seroresponse after a natural infection, which are summarized in this article (a persistent DNA infection, increased viral load, immunosuppression and high sexual risk behavior), can help to interpret these indirect effects better.
Adaptation of Connexin 43-Hemichannel Prostaglandin Release to Mechanical Loading (2008)

Bone tissues respond to mechanical loading/unloading regimens to accommodate (re)modeling requirements; however, the underlying molecular mechanism responsible for these responses is largely unknown. Previously, we reported that connexin (Cx) 43 hemichannels in mechanosensing osteocytes mediate the release of prostaglandin, PGE 2 , a crucial factor for bone formation in response to anabolic loading. We show here that the opening of hemichannels and release of PGE 2 by shear stress were significantly inhibited by a potent antibody we developed that specifically blocks Cx43-hemichannels, but not gap junctions or other channels. The opening of hemichannels and release of PGE 2 are magnitude-dependent on the level of shear stress. Insertion of a rest period between stress enhances this response. Hemichannels gradually close after 24 h of continuous shear stress corresponding with reduced Cx43 expression on the cell surface, thereby reducing any potential negative effects of channels staying open for extended periods. These data suggest that Cx43-hemichannel activity associated with PGE 2 release is adaptively regulated by mechanical loading to provide an effective means of regulating levels of extracellular signaling molecules responsible for initiation of bone (re)modeling.
The <i>Arabidopsis</i> homeotic genes <i>APETALA3</i> and <i>PISTILLATA</i> are sufficient to provide the B class organ identity function (1996)

The class B organ identity genes, APETALA3 and PISTILLATA, are required to specify petal and stamen identity in the Arabidopsis flower. We show here that the activities of these two genes are sufficient to specify petals and stamens in flowers, in combination with the class A and C genes, respectively. Flowers of plants constitutively expressing both PISTILLATA and APETALA3 under the control of the 35S promoter from cauliflower mosaic virus consist of two outer whorls of petals and inner whorls of stamens. These plants also exhibit vegetative phenotypes that are not present in either of the singly (APETALA3 or PISTILLATA) overexpressing lines. These phenotypes include leaf curling and the partial conversion of later-arising cauline leaves to petals. The presence of additional floral whorls in flowers ectopically expressing APETALA3 and PISTILLATA and the rescue of missing organs in class A mutants by ectopic B function suggest that APETALA3 and PISTILLATA play an additional role in proliferation of the floral meristem.
365. The morphine–thebaine group of alkaloids. Part VI. The condensation of thebaine with dienophils (1956)

K. W. Bentley and A. F. Thomas, J. Chem. Soc., 1956, 1863 DOI: 10.1039/JR9560001863
Automatically Annotating Topics in Transcripts of Patient-Provider Interactions via Machine Learning (2013)

This foray into automated topic inference suggests that machine learning methods can classify utterances comprising patient-provider interactions into clinically relevant topics with reasonable accuracy.
Acute ischemic stroke (2009)

Tenecteplase 0.1 mg/kg, using advanced imaging guidance in an extended time window, may have significant biologic efficacy in acute ischemic stroke. The imaging selection differences between the tenecteplase and alteplase groups prevent a conclusive efficacy comparison. Nonetheless, these results lend support for randomized trials comparing tenecteplase with alteplase, preferably incorporating penumbral/angiographic imaging selection.
Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer (2017)

Acquired resistance to cyclin-dependent kinases 4 and 6 (CDK4/6) small-molecule inhibitors in breast cancer arises through mechanisms that are yet uncharacterized. In this study, we used a kinome-wide siRNA screen to identify kinases that, when downregulated, yield sensitivity to the CDK4/6 inhibitor ribociclib. In this manner, we identified 3-phosphoinositide-dependent protein kinase 1 (PDK1) as a key modifier of ribociclib sensitivity in estrogen receptor-positive MCF-7 breast cancer cells. Pharmacologic inhibition of PDK1 with GSK2334470 in combination with ribociclib or palbociclib, another CDK4/6 inhibitor, synergistically inhibited proliferation and increased apoptosis in a panel of ER-positive breast cancer cell lines. Ribociclib-resistant breast cancer cells selected by chronic drug exposure displayed a relative increase in the levels of PDK1 and activation of the AKT pathway. Analysis of these cells revealed that CDK4/6 inhibition failed to induce cell-cycle arrest or senescence. Mechanistic investigations showed that resistant cells coordinately upregulated expression of cyclins A, E, and D1, activated phospho-CDK2, and phospho-S477/T479 AKT. Treatment with GSK2334470 or the CDK2 inhibitor dinaciclib was sufficient to reverse these events and to restore the sensitivity of ribociclib-resistant cells to CDK4/6 inhibitors. Ribociclib, in combination with GSK2334470 or the PI3Kα inhibitor alpelisib, decreased xenograft tumor growth more potently than each drug alone. Taken together, our results highlight a role for the PI3K-PDK1 signaling pathway in mediating acquired resistance to CDK4/6 inhibitors. <i>Cancer Res; 77(9); 2488-99. ©2017 AACR</i>.
Filtered technetium-99m-sulfur colloid evaluated for lymphoscintigraphy. (1995)

Filtered 99mTc-SC can be easily prepared and is readily available for routine clinical use in lymphoscintigraphic studies.
Effects of Hemerocallis on sleep in mice (1998)

Freeze-dried flowers of the Akinowasuregusa (Hemerocallis fulva L. var. sempervirona M. Hotta), a Hemerocallis genus of the lily family, were fed to C57BL strain mice. The slow wave sleep and paradoxical sleep of the Hemerocallis-treated group increased during the dark period. The differences between the control group and the Hemerocallis-treated group were significant (P < 0.05). The Hemerocallis feeding did not cause a change in sleep time during the light period. As a result, there was no significant change in the sleep-time percentage over a 24-h period.
Handwriting Trajectory Recovery using End-to-End Deep Encoder-Decoder Network (2018)

In this paper, we introduce a novel technique to recover the pen trajectory of offline characters which is a crucial step for handwritten character recognition. Generally, online acquisition approach has more advantage than its offline counterpart as the online technique keeps track of the pen movement. Hence, pen tip trajectory retrieval from offline text can bridge the gap between online and offline methods. Our proposed framework employs sequence to sequence model which consists of an encoder-decoder LSTM module. The proposed encoder module consists of Convolutional LSTM network, which takes an offline character image as the input and encodes the feature sequence to a hidden representation. The output of the encoder is fed to a decoder LSTM and we get the successive coordinate points from every time step of the decoder LSTM. Although the sequence to sequence model is a popular paradigm in various computer vision and language translation tasks, the main contribution of our work lies in designing an end-to-end network for a decade old popular problem in document image analysis community. Tamil, Telugu and Devanagari characters of LIPI Toolkit dataset are used for our experiments. Our proposed method has achieved superior performance compared to the other conventional approaches.
Using in Vivo Bioluminescence Imaging to Shed Light on Cancer Biology (2005)

Luciferases are light-emitting enzymes that have been used as reporters of biological function for several decades, and have more recently been used as reporters for the study of biological processes in living animals. Although these enzymes appear to have evolved independently in different species, they are all oxygenases that require energy, a chemical substrate, and oxygen. The technologies of detecting their weak bioluminescent signals in the bodies of living rodent models of human biology and disease, comprise the optical imaging method called in vivo bioluminescence imaging (BLI). BLI has been applied to a number of questions in cancer research, including studies of tumor burden, response to therapy, assessment of gene expression, and development of metastatic lesions. The considerations necessary for evaluating image data obtained by this method, the advances in technology development, and recent applications in the study of cancer are the focus of this paper.
Calorimetric Determination of Thermodynamic Parameters of Reaction Reveals Different Enthalpic Compensations of the Yeast Hexokinase Isozymes (2003)

The change in enthalpy and rate constants for the reactions of yeast hexokinase isozymes, PI (Hxk1) and PII (Hxk2), was determined at pH 7.6 and 25 degrees C by isothermal titration calorimetry. The reactions were done in five buffer systems with enthalpy of protonation varying from -1.22 kcal/mol (phosphate) to -11.51 kcal/mol (Tris), allowing the determination of the number of protons released during glucose phosphorylation. The reaction is exothermic for both isozymes with a small, but significant (p < 0.0001), difference in the enthalpy of reaction (Delta HR), with an Delta HR of -5.1 +/- 0.2 (mean +/- S.D.) kcal/mol for Hxk1, and an Delta HR of -3.3 +/- 0.3 (mean +/- S.D.) kcal/mol for Hxk2. The Km for ATP determined by ITC was very similar to those reported in the literature for both isozymes. The effect of NaCl and KCl, from 0 to 200 mM, showed that although the rate of reaction decreases with increasing ionic strength, no change in the Delta HR was observed suggesting an entropic nature for the ionic strength. The differences in Delta HR obtained here for both isozymes strongly suggest that, besides glucose phosphorylation, another side reaction such as ATP hydrolysis and/or enzyme phosphorylation is taking place.
Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. (1999)

Infection with Chlamydia pneumoniae is a common cause of acute respiratory disease in man and is also associated with atherosclerotic cardiovascular disorder. Herein, we have compared bacterial load and immune parameters of C. pneumoniae-infected mice genomically lacking T cell coreceptors, cytokine receptors, or cytotoxic effector molecules. A protective role for CD8+ cells is shown by the enhanced severity of infection of CD8-/- or TAP-1-/-/beta2-microglobulin -/- mice. CD8+ cells hindered a parasite growth-promoting role of CD4+ T cells, as indicated by the higher sensitivity to early infection of CD8-/- than CD4-/-/CD8-/- mice, which was further confirmed in experiments in which SCID mice were reconstituted with either CD4+ or CD4+ plus CD8+ T cells. Interestingly, CD4+ T cells played a dual role, detrimental early (14 and 24 days) after infection but protective at later time points (60 days after infection). The CD8+ T cell protection was perforin independent. The early deleterious role of CD4+ in the absence of CD8+ T cells was associated with enhanced IL-4 and IL-10 mRNA levels and delayed IFN-gamma mRNA accumulation in lungs. In line with this, IFN-gammaR-/- (but not TNFRp55 -/-) mice showed dramatically increased susceptibility to C. pneumoniae, linked to reduced inducible nitric oxide synthase (iNOS) mRNA accumulation, but not to diminished levels of specific Abs. The increased susceptibility of iNOS-/- mice indicates a protective role for iNOS activity during infection with C. pneumoniae. The higher sensitivity of IFN-gammaR-/- mice to C. pneumoniae compared with that of SCID or recombination-activating gene-1-/- mice suggested a relevant protective role of IFN-gamma-dependent innate mechanisms of protection.
A New Insight into the Formation of Osteolytic Lesions in Multiple Myeloma (2003)

Multiple myeloma is a cancer in which immunoglobulin-producing plasma cells undergo clonal expansion. Its characteristic feature is the monoclonal, or M, spike, usually detectable in serum or urine by protein electrophoresis. Malignant plasma cells have complex chromosomal rearrangements, leading in many cases to the aberrant activation of gene expression. Some of these activated genes encode secreted factors that can modify the microenvironment of the tumor in a manner that favors its growth or promotes its ability to cause lesions in surrounding tissues. The mechanism of bone destruction, a feature of multiple myeloma, is the focus of the article by Tian . . .
Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates (2007)

In all biological systems, protein amount is a function of the rate of production and clearance. The speed of a response to a disturbance in protein homeostasis is determined by turnover rate. Quantifying alterations in protein synthesis and clearance rates is vital to understanding disease pathogenesis (e.g., aging, inflammation). No methods currently exist for quantifying production and clearance rates of low-abundance (femtomole) proteins in vivo. We describe a novel, mass spectrometry-based method for quantitating low-abundance protein synthesis and clearance rates in vitro and in vivo in animals and humans. The utility of this method is demonstrated with amyloid-beta (Abeta), an important low-abundance protein involved in Alzheimer's disease pathogenesis. We used in vivo stable isotope labeling, immunoprecipitation of Abeta from cerebrospinal fluid, and quantitative liquid chromatography electrospray-ionization tandem mass spectrometry (LC-ESI-tandem MS) to quantify human Abeta protein production and clearance rates. The method is sensitive and specific for stable isotope-labeled amino acid incorporation into CNS Abeta (+/-1% accuracy). This in vivo method can be used to identify pathophysiologic changes in protein metabolism and may serve as a biomarker for monitoring disease risk, progression, or response to novel therapeutic agents. The technique is adaptable to other macromolecules, such as carbohydrates or lipids.
Transforming Fractals (2014)

This issue's article examines the digital artwork of Rod Seeley, who transforms basic fractal images into complex works of art.
HOW MUCH DO THEY MAKE BY JUST STANDING THERE? DEAL FLOW ALLOCATION AS A STRUCTURAL DETERMINANT OF VC PERFORMANCE (2011)

This study suggests a theoretical complement to thus far proposed explanations of disproportionate returns in the venture capital industry. Departing from a focus on firm-specific resources, we develop a model and simulate a process of hierarchical market allocation, in which the most promising ventures are allocated to venture capital firms (VCFs) in the order of a generally shared criterion, such as reputation, status, or expected value of VCF’s contribution to venture. The second part of the study tests proposed relationships from the simulation on a sample of 227 US early stage VC funds. The findings suggest that the mechanism of hierarchical market allocation is a significant driver of systemic differences in VCFs’ performance. Importantly, this effect is not specific to characteristics of any individual VCF, but to the VCF’s position in the hierarchy. Both simulation and empirical findings show that performance of the VCF is curvilinearly related to the position in hierarchy: the higher up the VCF moves in the hierarchy, the higher the marginal effect on performance.
Fault‐plane reflections as a diagnostic of pressure differences in reservoirs: a case study (2003)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2003Fault‐plane reflections as a diagnostic of pressure differences in reservoirs: a case studyAuthors: Matthew HaneyJon SheimanRoel SniederSteve NarukJay BuschScott WilkinsMatthew HaneyCenter for Wave Phenomena, Colorado School of Mines, Golden, CO 80401, Jon SheimanShell International Exploration and Production Inc., Houston, TX 77025, Roel SniederCenter for Wave Phenomena, Colorado School of Mines, Golden, CO 80401, Steve NarukShell International Exploration and Production Inc., Houston, TX 77025, Jay BuschShell International Exploration and Production Inc., Houston, TX 77025, and Scott WilkinsShell International Exploration and Production Inc., Houston, TX 77025https://doi.org/10.1190/1.1817922 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1817922FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 2003ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2003 Pages: 2452 publication data© 2003 Copyright © 2003 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 03 Jan 2005 CITATION INFORMATION Matthew Haney, Jon Sheiman, Roel Snieder, Steve Naruk, Jay Busch, and Scott Wilkins, (2003), "Fault‐plane reflections as a diagnostic of pressure differences in reservoirs: a case study," SEG Technical Program Expanded Abstracts : 362-365. https://doi.org/10.1190/1.1817922 Plain-Language Summary PDF DownloadLoading ...
Evidence of Self-Gasification during the Microwave-Induced Pyrolysis of Coffee Hulls (2006)

Pellets of coffee hulls were pyrolyzed at different temperatures using microwave and electrical heating. A comparison of the gas composition obtained by both methods suggests that the different mechanisms of heating that take place in the microwave, in comparison to conventional heating, give rise to the formation of “microplasmas”, which induce self-gasification of the char that is being formed. This hypothesis was corroborated by subjecting the char to reaction with CO2 at different temperatures using both methods of heating. The results showed that, whereas the transition in the reaction mechanism controlling the Boudouard reaction (i.e., chemical or diffusional control) takes place at about 800 °C in conventional heating, in the case of microwave heating the temperature is much lower and the reaction never proceeds under pure chemical control, the differences between microwave and conventional heating being quite significant even at low temperatures.