gebhart/patrepeval huggingface dataset:
Evaluation of bone healing enhancement by lyophilized bone grafts supplemented with platelet gel: A standardized methodology in patients with tibial osteotomy for genu varus (2005)

Orthopedic practice may be adversely affected by an inadequate bone repair that might compromise the success of surgery. In recent years, new approaches have been sought to improve bone healing by accelerating the rate of new bone formation and the maturation of the matrix. There is currently great interest in procedures involving the use of platelet gel (PG) to improve tissue healing, with satisfactory results both in vitro and in maxillofacial surgery. Otherwise, to our knowledge, only a preliminary clinical study was undertaken in the orthopedic field [Kitoh et al., Bone 2004;35:892-898] and the efficacy of PG is still controversial. Our paper focuses on the effect on bone regeneration by adding PG to lyophilized bone chips used for orthopedic applications. The clinical model and the laboratory methodology were standardized. As a clinical model, we employed the first series of patients of a randomized case-control study undergoing high tibial osteotomy (HTO) for genu varus. Ten subjects were enrolled: in 5 patients lyophilized bone chips supplemented with PG were inserted during tibial osteotomy (group A); 5 patients were used as a control (group B) and lyophilized bone chips without gel were applied. Forty-five days after surgery, computed tomography scan guided biopsies of grafted areas were obtained and the bone maturation was evaluated by a standardized methodology: the osteogenic and angiogenic processes were semi-quantitatively characterized by using histomorphometry, and the mineral component of the lyophilized and host bone was analyzed by using X-ray diffraction technique with sample microfocusing and microradiography. Lyophilized bone with PG seems to accelerate the healing process, as shown by new vessel formation and deposition of newly formed bone, with no evidence of inflammatory cell infiltrate, when compared with lyophilized bone without gel. On the contrary, lyophilized bone undergo a resorption process, and a fibrous tissue often fills the spaces between chips. A histiocytic/giant-cell reaction is sometimes present. Otherwise, no differences have been found concerning microstructure. Our findings show the reliability of the methodology used to monitor early bone repair. The completion of the study and the evaluation of the ultimate clinical outcome are necessary in order to verify PG in vivo effects in orthopedic surgery.
Use of hyaluronan in the selection of sperm for intracytoplasmic sperm injection (ICSI): significant improvement in clinical outcomes—multicenter, double-blinded and randomized controlled trial (2012)

The study included clinics using different sperm preparation methods, located in different regions of the USA and proceeded in every month of the year. Therefore, the results are widely applicable.
Interaction of Restriction Endonucleases with Phosphorothioate-Containing DNA (1991)

Abstract The requirements for inhibition of cleavage of phosporothioate-containing DNA by the restriction enzymes BanII and EcoRV with respect to number and position of these groups was determined.
ChemInform Abstract: Synthesis of (24R)‐24,25‐Dihydroxyvitamin D3. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Study on professional medical education and training of rural health talents in the new situation (2008)

In order to adapt the new situation of rural area medical and health system reform and explore a new type of rural health personnel training model, Luohe Medical College adjusts and optimizes the program setting, introduce into high-level professional and technical talents, strengthen basic construction of teaching continuously, and promote practical teaching actively, pay attention to the reform of teaching system, teaching model, and practical teaching. It is important that connecting medical college education in the new situation with the rural grassroots health manpower needs closely, setting the right training goal and expanding the specialty caliber.

Key words: 
Rural health talent;  Training model;  Professional medical education
Synthesis and in vitro characterization of novel amino terminally modified oxotremorine derivatives for brain muscarinic receptors (1992)

A series of novel 2-substituted acetylenic pyrrolidines and piperidines related to oxotremorine (1) were prepared and evaluated in vitro as muscarinic cholinergic agents at brain M1 and M2 receptors. One analogue, 3-(2-oxo-1-pyrrolidinyl)-1-[2(R)-pyrrolidinyl]-1-propyne hydrogen oxalate (6a), was found to be a partial agonist producing a PI hydrolysis response at cortical M1 receptors approximately 3-fold larger than that produced by 1. The intrinsic activity profile of 6a at brain muscarinic receptors is similar to those of azetidine oxo analogue 2 and dimethylamino oxo analogue. All three compounds are partial M1 agonists and full M2 agonists; however, the profile of 6a in binding studies is significantly different. While 2 and 3 exhibit large M2 selectivities ranging between 8-fold to several hundred-fold, the binding profile of 6a shows almost no subtype selectivity.
Examples of unicity subspaces in L<sub>1</sub>-approximation (1987)

The purpose of this paper is to study the problem of existence of subspaces G of C(X) where is a compact disconnected subset of the real line or a compact subset of such that G guarantees uniqueness of best L1-approximations for weighted approximation of continuous real-valued functions. Some examples of such subspaces, including subspaces of polynomials and linear spline functions of two variables, are presented.
Formation of mononuclear nitrido complexes of chromium(<scp>VI</scp>) and molybdenum(<scp>VI</scp>); syntheses and X-ray crystal structures of NCr(OBu<sup>t</sup>)<sub>3</sub>and NMo(OSiMe<sub>3</sub>)<sub>3</sub>(py) (1996)

Mononuclear nitrido complexes of Cr and Mo, NCr(OBut)3 and NMo(OSiMe3)3(py), are synthesized; the chromium complex has an idealized C3ν symmetry while the molybdenum complex has a distorted square-pyramidal geometry with the nitrido ligand at apical position; the N–Cr distance is 1.538(5)Å while the average N–Mo distance is 1.627 Å.
Preliminary Evaluation of Whole-Blood Gamma Interferon Release for Clinical Assessment of Cellular Immunity in Patients with Active Coccidioidomycosis (2005)

Assessment of the cellular immune response in coccidioidomycosis has epidemiologic and prognostic importance. Measurement of delayed-type hypersensitivity to skin testing has been used in the past to determine cellular immunity in coccidioidomycosis. However, no skin tests are currently available in the United States. Assay of gamma interferon (IFN-gamma) release in whole blood in response to incubation with antigen has been used to assess cellular immunity in tuberculosis. We used a similar assay using the coccidioidal antigen preparation T27K to measure the in vitro cellular immune responses among a cohort of 69 subjects with active coccidioidomycosis. IFN-gamma release was bimodal, with concentrations above and below 5 IU/ml. Using multivariate logistic regression, underlying disease and disseminated or chronic pulmonary coccidioidomycosis was significantly associated with the release of IFN-gamma at a concentration of <5 IU/ml (P = 0.02 or 0.05, respectively). In addition, the release IFN-gamma concentration was <5 IU/ml in all subjects with a clinical severity score of > or =6 (P = 0.02). The release IFN-gamma concentration correlated with expression of CD69 on T lymphocytes in an in vitro assay using T27K as the antigen (Spearman's rho = 0.59; P < 0.01). These results suggest that the IFN-gamma release assay with T27K as the antigen may be a useful clinical test for assessing cellular immunity in patients with active coccidioidomycosis.
New mammary epithelial and fibroblastic cell clones in coculture form structures competent to differentiate functionally. (1989)

We have established and characterized a spontaneously immortalized, nontumorigenic mouse mammary cell line, designated IM-2. IM-2 cells synthesize large amounts of the milk protein beta-casein upon addition of lactogenic hormones. The induction of beta-casein occurs rapidly and does not require any exogenous extracellular matrix components. The IM-2 cell line is morphologically heterogeneous and could be separated into cell clones with epithelial and fibroblastic characteristics. In monoculture, none of the epithelial clones could be induced to synthesize caseins. Coculture of epithelial and fibroblastic clones, however, rendered the epithelial cells competent to differentiate functionally; the addition of lactogenic hormones to these cocultures resulted in the synthesis of beta-casein in amounts comparable to that seen with the original IM-2 line. Using this unique cell system, we have investigated the interrelationships between different steps in differentiation leading to hormone-induced casein production. Independent of hormones, epithelial-fibroblastic cell contacts led to the formation of characteristic structures showing the deposition of laminin. We found that the epithelial cells located in these structures also exhibited significantly increased levels of cytokeratin intermediate filament polypeptides. Double immunofluorescence revealed that the cells inducible by hormones to synthesize casein, colocalized exactly with the areas of laminin deposition and with the cells showing greatly intensified cytokeratin expression. These results suggest that hormone-independent differentiation events take place in response to intercellular epithelial-mesenchymal contacts. These events in turn bring about a state of competence for functional differentiation after lactogenic hormonal stimulation.
VpreB surrogate light chain expression in B-lineage ALL: a report from the Children’s Oncology Group (2021)

Immunotherapies directed against B-cell surface markers have been a common developmental strategy to treat B-cell malignancies. The immunoglobulin heavy chain surrogate light chain (SLC), comprising the VpreB1 (CD179a) and Lamda5 (CD179b) subunits, is expressed on pro- and pre-B cells, where it governs pre-B-cell receptor (BCR)-mediated autonomous survival signaling. We hypothesized that the pre-BCR might merit the development of targeted immunotherapies to decouple "autonomous" signaling in B-lineage acute lymphoblastic leukemia (B-ALL). We used the Children's Oncology Group (COG) minimal residual disease (MRD) flow panel to assess pre-BCR expression in 36 primary patient samples accrued to COG standard- and high-risk B-ALL studies through AALL03B1. We also assessed CD179a expression in 16 cases with day 29 end-induction samples, preselected to have ≥1% MRD. All analyses were performed on a 6-color Becton-Dickinson flow cytometer in a Clinical Laboratory Improvement Amendment/College of American Pathologist-certified laboratory. Among 36 cases tested, 32 cases were at the pre-B and 4 cases were at the pro-B stages of developmental arrest. One or both monoclonal antibodies (mAbs) showed that CD179a was present in ≥20% of the B-lymphoblast population. All cases expressed CD179a in the end-induction B-lymphoblast population. The CD179a component of the SLC is commonly expressed in B-ALL, regardless of genotype, stage of developmental arrest, or National Cancer Institute risk status.
Facial recognition: back from the brink of a ban? (2021)

In recent weeks, the pressure on governments worldwide to ban the use of live facial recognition (LFR) technology has reached new levels.
A Hippocampal NR2B Deficit Can Mimic Age-Related Changes in Long-Term Potentiation and Spatial Learning in the Fischer 344 Rat (2002)

Aged rats are known to have deficits in spatial learning behavior in the Morris water maze. We have found that aged rats also have deficits in NR2B protein expression and that the protein expression deficit is correlated with their performance in the Morris water maze. To test whether this NR2B deficit was sufficient to account for the behavioral deficit, we used antisense oligonucleotides to specifically knock down NR2B subunit expression in the hippocampus of young rats. NR2B antisense treatment diminished NMDA receptor responses, abolished NMDA-dependent long-term potentiation (LTP), and impaired spatial learning. These data demonstrate the important role of NR2B in LTP and learning and memory and suggest a role for reduced NR2B expression in age-related cognitive decline.
Conformationally restrained, chiral (phenylisopropyl)amino-substituted pyrazolo[3,4-d]pyrimidines and purines with selectivity for adenosine A1 and A2 receptors (1992)

Two modes of tethering a chiral (phenylisopropyl)amino substituent in pyrazolo[3,4-d]pyrimidines and purines have been explored. One mode gave (S)-2,7-dihydro-7-phenyl-2-(phenylmethyl)-5- propoxy-3H-imidazo[1,2-c]pyrazolo-[4,3-e]pyrimidine (12a) and its corresponding R-enantiomer 12b, which were selective for A2 and A1 adenosine receptors, respectively. The corresponding diimidazo[1,2-c:4',5'-e]pyrimidines 12e and 12f were analogously selective. This is the first example where a single chiral recognition unit provides enantiomers with opposite selectivities for adenosine receptors. The second mode gave (2S-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5- propoxy-3H-imidazo[1,2-c]-pyrazolo[4,3-e]pyrimidine (12c) and its corresponding R-enantiomer 12d. Compounds 12c and 12d were significantly less potent than 12a and 12b at A1 receptors, and were nonselective.
Thyrocalcitonin: Inhibitor of Bone Resorption in Tissue Culture (1965)

A partially purified protein from thyroid glands of rats inhibits release of calcium from long bones of embryo rats in tissue culture. Inhibition was more easily detected when resorption of bone was stimulated by parathyroid hormone.
Interleukin-1 activates transcription factor NF<i>κ</i> B in glial cells (1993)

Recombinant human interleukin-1 (IL-1) alpha and beta were found to activate a latent cytosolic form of the transcription factor NF kappa B in rat C6 glioma. IL-1 beta was 10 times more potent than IL-1 alpha for this activity and both were inhibited by the IL-1 receptor antagonist. The activation was detectable from 20 min and remained sustained for up to 24 h. The electrophoretic mobility of the activated complex was shown to be different from that of the corresponding complexes in another IL-1-responsive cell line, the murine thymoma line EL4.NOB-1. C6 cells, when transiently transfected with five NF kappa B consensus sequence repeats linked to the reporter gene chloramphenicol acetyltransferase (CAT), demonstrated increased CAT activity in response to IL-1 beta treatment. The activation of NF kappa B in glial cells may thus represent an early step in IL-1 signalling in brain and is likely to have consequences for IL-1-induced gene expression in these cells.
Corrosion Benefits of Piperazine As an Alternative CO<sub>2</sub>Capture Solvent (2014)

The corrosion behavior of A106 carbon steel in piperazine, an advanced alternative postcombustion CO2 capture solvent to monoethanolamine, has been investigated. Electrochemical corrosion testing methods such as linear polarization resistance (LPR) and electrochemical impedance spectroscopy (EIS) have been used to evaluate the corrosion of A106 in 0.43 mol CO2/mol alkalinity (C/N) loaded 30 wt % piperazine at 80 °C for 150 h. In addition, immersion corrosion has been carried out up to 1050 h in a traditional corrosion cell with the same CO2 loaded solution but at 100 °C and 110 psi. Subsequently, as-corroded A106 samples were characterized by scanning electron microscopy/energy dispersive spectroscopy (SEM/EDS) and X-ray diffraction (XRD). The results showed that a sharp decrease in the corrosion rate occurred before reaching a steady-state corrosion process. This was due to the growth of a protective and stable layer of FeCO3. Possible mechanisms are discussed.
Papillomavirus in the Vapor of Carbon Dioxide Laser-Treated Verrucae (1989)

No AccessJournal of Urology1 Jan 1989Papillomavirus in the Vapor of Carbon Dioxide Laser-Treated Verrucae J.M. Garden, M.K. O'Banion, L.S. Shelnitz, K.S. Pinski, A.D. Bakus, M.E. Reichmann, and J.P. Sundberg J.M. GardenJ.M. Garden , M.K. O'BanionM.K. O'Banion , L.S. ShelnitzL.S. Shelnitz , K.S. PinskiK.S. Pinski , A.D. BakusA.D. Bakus , M.E. ReichmannM.E. Reichmann , and J.P. SundbergJ.P. Sundberg View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)40716-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Papillomavirus in the Vapor of Carbon Dioxide Laser-Treated Verrucae." The Journal of Urology, 141(1), pp. 223–224 © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 141Issue 1January 1989Page: 223-224 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information J.M. Garden More articles by this author M.K. O'Banion More articles by this author L.S. Shelnitz More articles by this author K.S. Pinski More articles by this author A.D. Bakus More articles by this author M.E. Reichmann More articles by this author J.P. Sundberg More articles by this author Expand All Advertisement PDF downloadLoading ...
Identification of bladder cancer antigens recognized by IgG antibodies of a patient with metastatic bladder cancer (2003)

To identify tumor antigens useful for the diagnosis and treatment of patients with bladder cancer, a lambda phage cDNA library constructed from a high-grade bladder cancer cell line was screened with autologous serum from a patient with metastatic bladder cancer. Forty-eight distinct antigens were isolated. By evaluating the immunogenicity and the tissue-specific expression, KU-BL-1 and KU-BL-2 were identified as immunogenic antigens with restricted tissue expression. KU-BL-1 was found to be a putative human lipoic acid synthetase with a metal-binding site, CXXXCXXC, that was expressed in bladder cancer cell lines and most bladder cancer tissues, as well as normal bladder mucosa and testis tissues. Immunoglobulin (Ig)G antibody to KU-BL-1 was detected in 2 of 28 patients with bladder cancer, but not in 30 healthy individuals. KU-BL-2 was found to be a putative human kelch-like protein that was homologous to Drosophila kelch, with a BTB/POZ domain and kelch repeats. KU-BL-2 was expressed in bladder cancer cell lines, most bladder cancer tissues, testis and heart, but not in normal bladder mucosa. IgG antibody to KU-BL-2 was detected in 8 of 28 patients with bladder cancer, but not in 16 healthy individuals. Tumor reactive T cells were induced from peripheral blood mononuclear cells (PBMC) by stimulation with one of the HLA-A24 binding KU-BL-2 peptides. Therefore, KU-BL-1 and KU-BL-2, which showed preferential expression in bladder cancer with restricted expression in normal tissues, as well as immunogenicity in multiple patients with bladder cancer, may be useful for the development of diagnostic and therapeutic methods for patients with bladder cancer.
Relationship of Light Quantity and Anthocyanin Production in <i>Pennisetum setaceum</i> Cvs. Rubrum and Red Riding Hood (2004)

Pennisetum setaceum cvs. Rubrum and Red Riding Hood are purple-pigmented ornamental grasses when grown in high-light environments. In low-light environments, foliage appears light purple or green, and as a result, aesthetic appeal is reduced. The impact of light on anthocyanin pigmentation was compared for P. setaceum Rubrum foliage and flowers and Red Riding Hood foliage grown under different light intensities and light sources. Light environments included UV supplemental light in the greenhouse, high-pressure sodium supplemental light in the greenhouse, cool-white fluorescent light in a growth chamber, and full sun outside. Anthocyanins in two cultivars of P. setaceum were analyzed by HPLC and characterized by (1)H and (13)C NMR spectral experiments. Two anthocyanins, cyanidin 3-glucoside and cyanidin 3-rutinoside, were identified in the leaves and flowers of both cultivars and quantified by HPLC analysis. The major anthocyanin in both cultivars was cyanidin 3-glucoside and had highest concentration (0.199% fresh weight) in Rubrum leaves grown under fluorescent lights in the growth chamber with a photoperiod of 24 h and a daily light integral (DLI) of 13.3 mol m(-)(2) day(-)(1) and in Rubrum and Red Riding Hood leaves and flowers (0.097 and 0.12% fresh weight) from plants grown outside in full sun with a photoperiod ranging from 15 to 13.5 h and DLI of 42 mol m(-)(2) day(-)(1). The minor anthocyanin, cyanidin 3-rutinoside, had the highest quantity in plants grown in low-light-intensity greenhouse environments with a photoperiod ranging from 15 to 13.5 h and DLI of 2.3-7.0 mol m(-)(2) day(-)(1). The functional significance of anthocyanins in P. setaceum Rubrum is discussed.
The oxidation states of silver (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe oxidation states of silverJohn C. Bailar Cite this: J. Chem. Educ. 1944, 21, 11, 523Publication Date (Print):November 1, 1944Publication History Received3 August 2009Published online1 November 1944Published inissue 1 November 1944https://doi.org/10.1021/ed021p523RIGHTS & PERMISSIONSArticle Views1267Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Modified ladder-type 2.4GHz SAW filter with transmission zero (2010)

This paper describes the design of 2.4-2.5GHz bandpass ladder-type SAW filter and methods to improve its characteristics. The structure of the filter is based on modified π-type topology with external matching inductors. The piezoelectric crystal (LiTaO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ) is placed on the low temperature co-fired ceramic (LTCC) substrate while all external elements are completely integrated into LTCC. Input sections of the filter with their characteristics were considered in detail what allowed to reduce the degradation of the filter characteristics due to increasing of its bandwidth. An effective way to create a transmission zero by introduction of magnetic coupling between input and output matching coils is presented in the paper.