gebhart/patrepeval huggingface dataset:
Prepulse inhibition deficits in patients with panic disorder (2002)

Prepulse inhibition (PPI) is an operational measure of sensorimotor gating that is reduced in several neuropsychiatric disorders that are characterized by deficits in inhibition or gating of intrusive or irrelevant stimuli. Clinically, panic disorder (PD) patients have been described as having difficulties in inhibition of responding to sensory and cognitive events. Because such difficulties may be due to failures in early stages of information processing, we examined PPI in patients with PD. Acoustic startle reactivity, habituation, and PPI (30-, 60-, 120-, 240-, and 2,000-ms interstimulus intervals) were assessed in patients with panic disorder (m/f = 10, 10) and age- and gender-matched healthy controls (m/f = 11, 10). PD patients were assessed with structured clinical interview for DSM-IV criteria with benzodiazepine treatment as an exclusion criterion. Panic disorder patients exhibited normal startle reactivity, reduced habituation, and significantly reduced PPI in the 30-, 60-, and 240-ms prepulse conditions. Within the PD group, the patients with high trait and state anxiety exhibited less PPI than patients with low trait and state anxiety. Furthermore, in PD patients, decreased PPI correlated significantly with high trait but not state anxiety. These data indicate that early stages of sensory information processing are abnormal in patients with PD. These observed deficits in PPI could reflect a more generalized difficulty in suppressing or gating information in panic disorder. The correlation between high trait anxiety and deficient PPI supports the hypothesis that sensorimotor gating abnormalities are an enduring feature of subjects with PD.
A CCD imager overlaid with a thin-film photodetector of a heterojunction ZnSe-Zn<sub>1-x</sub>Cd<sub>x</sub>Te (1983)

A CCD imager which is composed of an interline transfer type scanner in the imaging area and a thin-film photodetector of a heterojunctjon ZnSe-Zn <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</inf> Cd <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> Te has been developed. The array consists of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">506^{V} \times 404^{H}</tex> picture elements. The imaging area is about <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6.7^{V} \times 9.0^{H}</tex> mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in size which corresponds to that of a 2/3-in vidicon. For the device to achieve high performance, necessary conditions between the parameters of the overlaid thin-film photoconductor and the scanner have been analyzed. Blooming phenomenon is deeply related to the sensitivity. The blooming has been suppressed without sacrificing the sensitivity by applying the pulse operation of the heterojunction. As a result, excellent performances such as high sensitivity and large blooming suppression have been realized. The scene illumination if F 1.4 100 1x (S/N ratio is 46 dB for luminance signal) in a single-chip color camera. The blooming control capability is 250 times of the saturation exposure.
Development and Characterization of Broadly Cross-reactive Monoclonal Antibodies Against All Known<i>Ebolavirus</i>Species (2015)

As of 25 March 2015, the largest recorded outbreak of Ebola virus infection is ongoing, with almost 25 000 cases and >10 000 deaths. There are 5 genetically and antigenically distinct species within the genus Ebolavirus. Limited cross-reactivity and protection is observed between these 5 Ebolavirus species, which complicates vaccine development. However, on the basis of sequence homology between the 5 Ebolavirus species, we hypothesize that conserved epitopes are present on the viral glycoprotein (GP), which can be targeted by antibodies. In the current study, a panel of mouse monoclonal antibodies was isolated and characterized using an enzyme-linked immunosorbent assay (ELISA) to determine cross-reactivity, avidity, and competition for epitope binding; Western blot analysis was also performed. Four monoclonal antibodies were identified by ELISA as cross-reacting with the GPs of all 5 Ebolavirus species. The identification of cross-reactive antibodies that bind the GPs of all known Ebolavirus species will give us important insight into the presence of conserved epitopes on the viral GP. These data will be crucial for the development of novel therapeutics and diagnostic assays.
CAD/CAM software framework design for the laser micromachining device driven by two stages (2010)

Laser processing has emerged in the last few years as the most widely accepted method of creating micro-vias in high-density electronic interconnect and chip packaging devices. This paper reports one kind of UV laser machine tool which has been applied to LTCC mass production lines and suitable for drilling micro-vias and cutting cavities for green tape with high productivity and high accuracy. It puts emphasis on the CAD/CAM software framework design for the described UV laser machine, which can overcome the challenges that the so-called compound laser beam positioning system driven by two stages brings to the software design. Some data processing techniques including scan field dividing, tool path generation, and scanner post processing, are presented.
Functional Analysis of the Molecular Factors Controlling Qa1-Mediated Protection of Target Cells from NK Lysis (2001)

CD94/NKG2 receptors on mouse NK cells recognize the nonclassical class I molecule Qa1 and can deliver inhibitory signals that prevent NK cells from lysing Qa1-expressing cells. However, the exact circumstances under which Qa1 protects cells from NK lysis and, in particular, the role of the dominant Qa1-associated peptide, Qdm, are unclear. In this study, we examined in detail the lysis of Qa1-expressing cells by fetal NK cells that express CD94/NKG2 receptors for Qa1 but that lack receptors for classical class I molecules. Whereas mouse L cells and human C1R cells transfected with Qa1 were resistant to lysis by these effectors, Qa1-transfected TAP-deficient human T2 cells showed no resistance despite expressing high levels of surface Qa1. However, these cells could be efficiently protected by exposure to low concentrations of Qdm peptide or certain Qdm-related peptides. By contrast, even prolonged exposure of TAP-deficient RMA/S cells to high doses of Qdm peptide failed to induce levels of surface Qa1 detectable with a Qa1-specific mAb or to protect them from NK lysis, although such treatment induced sensitivity to lysis by Qa1-specific CTL. Collectively, these findings indicate that high surface expression of Qa1 is necessary but not sufficient for protection, and that effective protection requires the expression of sufficient levels of suitable Qa1-peptide complexes to overcome activatory signals. Results obtained with a series of substituted Qdm peptides suggest that residues at positions 3, 4, 5, and 8 of the Qdm sequence, AMAPRTLLL, are important for recognition of Qa1-Qdm complexes by inhibitory CD94/NKG2 receptors.
Analysis of steady-state and transient thermal properties of cermet, polymer and LTCC thick-film resistors (2014)

Purpose – The purpose of this paper is to present the results of thermal analysis of cermet resistors made on alumina or LTCC substrate and polymer thick-film resistors embedded in FR-4 substrate. Design/methodology/approach – The study was performed using a thermal imaging method. The research was carried out with an additional consideration of such factors as sheet resistance (which depended on the type of resistive paste), the size and topology of element and the kind of contact material (Cu, Ag or Ni/Au). A few key points on the element were specified for which a more thorough analysis was carried out. The results were approximated by physically acceptable function which allowed to determine the influence of different mechanisms of heat transfer and determine their time and thermal constants. Findings – The effectiveness of heat dissipation from resistor is determined by the type of substrate material, width of conductive paths, and contact material. The best results were observed for elements with wider conductive paths made of Cu or Ni/Au. The LTCC substrate ensures the fastest achieving of stable temperature on the component. The changes of the temperature gradient in time can be described by a formula consisting of two or three exponent parts, each one presenting different mechanism of change. Research limitations/implications – These studies do not include more detailed determination of nature of found mechanisms of change. There has not also been established what form of the formula is more accurate physically description of the results for respective structure. Originality/value – The results provide important data of the thermal properties of the chosen materials. This allows to determine their usability for specific applications where heat distribution plays an important role. The used analysis method is proven to provide reliable results and can be considered to be used for further studies in that subject.
Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase. (1991)

Inositol polyphosphate-5-phosphatase (5-phosphatase) hydrolyzes inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate and thereby functions as a signal terminating enzyme in cellular calcium ion mobilization. A cDNA encoding human platelet 5-phosphatase has been isolated by screening for beta-galactosidase fusion proteins that bind to inositol 1,3,4,5-tetrakisphosphate. The sensitivity of the screening procedure was enhanced 50- to 100-fold by amplification of "sublibraries" prior to carrying out binding assays. The sequences derived from the "expression clone" were used to screen human erythroleukemia cell line and human megakaryocytic cell line cDNA libraries. We obtained two additional clones which together consist of 2381 base pairs. The amino-terminal amino acid sequence from the 75-kDa 5-phosphatase purified from platelets is identical to amino acids 38-56 predicted from the cDNA. This suggests that the platelet 5-phosphatase is formed by proteolytic processing of a larger precursor. The cDNA predicts that the mature enzyme contains 635 amino acids (Mr 72, 891). Antibodies directed against recombinant TrpE fusion proteins of either an amino-terminal region or a carboxyl-terminal region immunoprecipitate the enzyme activity from a preparation of the 75-kDa form of platelet 5-phosphatase (Type II) but do not precipitate the distinct 47-kDa 5-phosphatase (Type I) also found in platelets. In addition, the recombinant protein expressed in Cos-7 cells has the same 5-phosphatase activity as the platelet 5-phosphatase.
Emerging ferroelectric transistors with nanoscale channel materials: the possibilities, the limitations (2016)

Combining the nonvolatile, locally switchable polarization field of a ferroelectric thin film with a nanoscale electronic material in a field effect transistor structure offers the opportunity to examine and control a rich variety of mesoscopic phenomena and interface coupling. It is also possible to introduce new phases and functionalities into these hybrid systems through rational design. This paper reviews two rapidly progressing branches in the field of ferroelectric transistors, which employ two distinct classes of nanoscale electronic materials as the conducting channel, the two-dimensional (2D) electron gas graphene and the strongly correlated transition metal oxide thin films. The topics covered include the basic device physics, novel phenomena emerging in the hybrid systems, critical mechanisms that control the magnitude and stability of the field effect modulation and the mobility of the channel material, potential device applications, and the performance limitations of these devices due to the complex interface interactions and challenges in achieving controlled materials properties. Possible future directions for this field are also outlined, including local ferroelectric gate control via nanoscale domain patterning and incorporating other emergent materials in this device concept, such as the simple binary ferroelectrics, layered 2D transition metal dichalcogenides, and the 4d and 5d heavy metal compounds with strong spin-orbit coupling.
Evolution of Hydrogen Storage Alloys Prepared by Special Methods (2004)

Microstructure characteristics and electrochemical properties of hydrogen storage alloys prepared by gas atomization, melt spinning and strip casting respectively were outlined.The advantages, disadvantages and research development of the above methods for preparing hydrogen storage alloys were explained.The strip casting is a new special means for preparing AB5 rare earth hydrogen storage alloys of high performance and low cost, and the study of the strip casting for preparing hydrogen storage alloys is presented specially.
Rb-Xe spin relaxation in dilute Xe mixtures (2001)

We present measurements of spin-relaxation of Rb atoms in $\mathrm{He}(98%)\ensuremath{-}{\mathrm{N}}_{2}(1%)\ensuremath{-}\mathrm{Xe}(1%)$ mixtures similar to those used in magnetic resonance imaging polarizers. The pressure dependence allows us to separate out contributions from Rb-Xe van der Waals molecules and binary collisions. For the first time, we observe the predicted increase in the molecular contribution at high pressure. Our data suggest that the deduced molecular breakup rate has a strong temperature dependence.
System Light-Loading Technology for mHealth: Manifold-Learning-Based Medical Data Cleansing and Clinical Trials in WE-CARE Project (2014)

Cardiovascular disease (CVD) is a major issue to public health. It contributes 41% to the Chinese death rate each year. This huge loss encouraged us to develop a Wearable Efficient teleCARdiology systEm (WE-CARE) for early warning and prevention of CVD risks in real time. WE-CARE is expected to work 24/7 online for mobile health (mHealth) applications. Unfortunately, this purpose is often disrupted in system experiments and clinical trials, even if related enabling technologies work properly. This phenomenon is rooted in the overload issue of complex Electrocardiogram (ECG) data in terms of system integration. In this study, our main objective is to get a system light-loading technology to enable mHealth with a benchmarked ECG anomaly recognition rate. To achieve this objective, we propose an approach to purify clinical features from ECG raw data based on manifold learning, called the Manifold-based ECG-feature Purification algorithm. Our clinical trials verify that our proposal can detect anomalies with a recognition rate of up to 94% which is highly valuable in daily public health-risk alert applications based on clinical criteria. Most importantly, the experiment results demonstrate that the WE-CARE system enabled by our proposal can enhance system reliability by at least two times and reduce false negative rates to 0.76%, and extend the battery life by 40.54%, in the system integration level.
Inhibition of nerve growth factor‐induced neurite outgrowth of PC12 cells by a protein kinase inhibitor which does not permeate the cell membrane (1991)

K-252a, a protein kinase inhibitor of microbial origin, has proven to be a specific inhibitor of nerve growth factor. In this study, the effects of K-252b, the 9-carboxylic acid derivative of K-252a, on nerve growth factor-induced neurite outgrowth in PC12 cells was examined. K-252b is hydrophilic and does not permeate the cell membrane of PC12 cells, whereas K-252a clearly does. K-252b is, however, as potent as K-252a itself in inhibiting the nerve growth factor-induced neurite outgrowth. These results can be interpreted to suggest that effects of K-252b may be through surface-bound/anchored K-252b-sensitive molecules on PC12 cells.
Systolic Pressure Variation Predicts the Response to Acute Blood Loss (1999)

ORNSTEIN, EUGENE; EIDELMAN, LEONID A.; DRENGER, BENJAMIN; ELAMI, AMIR; PIZOV, REUVEN Author Information
SUCCESS-DWA: a highly scalable and cost-effective optical access network (2004)

Passive optical networks have been identified as promising access solutions that can open the first-mile bottleneck, bringing gigabits-per-second data rates to end users. Current TDM PONs enjoy low cost by sharing resources in time, but suffer from limited capacity. In the future, WDM technology may be employed to achieve high performance. In this article we introduce a novel PON employing dynamic wavelength allocation to provide bandwidth sharing across multiple physical PONs. Tunable lasers, arrayed waveguide gratings, and coarse/fine filtering combine to create a flexible new optical access solution. The network's excellent scalability can bridge the gap between conventional TDM PONs and WDM PONs. The powerful architecture is a promising candidate for next-generation optical access networks.
Night-Time EKG and HRV Monitoring With Bed Sheet Integrated Textile Electrodes (2012)

A system for unobtrusive night-time electrocardiogram (EKG) and heart rate variability (HRV) monitoring as well as data analysis methods are presented, comparing bed sheet HR and HRV values with corresponding parameters obtained by a reference measurement. Our system uses eight embroidered textile electrodes attached laterally to a bed sheet for measuring bipolar contact EKG from multiple channels. The electrodes are arranged in a line so that at least two adjacent electrodes make sufficient skin contact. The focus of the signal processing development has been on selecting the best measurement channel for further analysis and minimizing the amount of incorrectly detected R-peaks. The test measurements were performed with four healthy men without previously known cardiac disorders and one who frequently had premature ventricular contractions (ectopic beats). For healthy test subjects, an average of 94.9% heartbeat detection coverage was achieved with the system during 29 measurement nights (in total 213.8 h of data). In most cases, the quality of the signal obtained from bed sheet electrodes is good enough for the computer-assisted cardiac arrhythmia detection. Applications for EKG derived RR-interval data include the calculation of HRV parameters that can be utilized in sleep quality analysis and other wellness-related topics as well as sleep apnoea detection.
Low-frequency pathophysiological characteristics of pediatric epileptic cortex during the interictal period detected using a dual-wavelength imaging system (2012)

In this pilot study, we explored the potential of using a diffuse reflectance imaging system to extract interictal pathophysiological characteristics of epileptic cortex in an intraoperative setting. The imaging system was able to simultaneously measure diffuse reflectance signals at two distinct wavelengths (500 and 700 nm) from the entire exposed cortical surface. It was used to study ten pediatric patients during their epilepsy surgery. Diffuse reflectance images, Rd(x,y,λ,t) at 500 nm and 700 nm, were acquired at a 5 Hz rate for at least 200 seconds. Post imaging analysis identified a unique local frequency oscillation (LFO), below respiration rate, existed in Rd(x,y,500 nm,t) and Rd(x,y,700 nm,t). Mapping the spectral densities of LFOs over the cortical surface identified the spatial distribution of the LFOs. In almost all ten patients studied, the location demonstrating strong LFOs coincided with the epileptic cortex determined using ECoG. However, some LFOs were found in close proximity to functional areas according to fMRI. We further used the correlation coefficient map to identify those pixels with similar waveforms for better demarcation. These preliminary results support the feasibility of using wavelength-dependent diffuse reflectance imaging to intra-operatively detect epileptic cortex.
Identification of the amino acids inserted during suppression of CFTR nonsense mutations and determination of their functional consequences (2017)

In-frame premature termination codons (PTCs) account for ∼11% of all disease-associated mutations. PTC suppression therapy utilizes small molecules that suppress translation termination at a PTC to restore synthesis of a full-length protein. PTC suppression is mediated by the base pairing of a near-cognate aminoacyl-tRNA with a PTC and subsequently, the amino acid becomes incorporated into the nascent polypeptide at the site of the PTC. However, little is known about the identity of the amino acid(s) inserted at a PTC during this process in mammalian cells, or how the surrounding sequence context influences amino acid incorporation. Here, we determined the amino acids inserted at the cystic fibrosis transmembrane conductance regulator (CFTR) W1282X PTC (a UGA codon) in the context of its three upstream and downstream CFTR codons during G418-mediated suppression. We found that leucine, cysteine and tryptophan are inserted during W1282X suppression. Interestingly, these amino acids (and their proportions) are significantly different from those recently identified following G418-mediated suppression of the CFTR G542X UGA mutation. These results demonstrate for the first time that local mRNA sequence context plays a key role in near-cognate aminoacyl-tRNA selection during PTC suppression. We also found that some variant CFTR proteins generated by PTC suppression exhibit reduced maturation and activity, indicating the complexity of nonsense suppression therapy. However, both a CFTR corrector and potentiator enhanced activity of protein variants generated by G418-mediated suppression. These results suggest that PTC suppression in combination with CFTR modulators may be beneficial for the treatment of CF patients with PTCs.
Mortality associated with oral contraceptive use: 25 year follow up of cohort of 46 000 women from Royal College of General Practitioners' oral contraception study (1999)

Oral contraceptives seem to have their main effect on mortality while they are being used and in the 10 years after use ceases. Ten or more years after use ceases mortality in past users is similar to that in never users.
Moving Walkways, Escalators, and Elevators (2007)

We study a simple geometric model of transportation facility that consists of two points between which the travel speed is high. This elementary definition can model shuttle services, tunnels, bridges, teleportation devices, escalators or moving walkways. The travel time between a pair of points is defined as a time distance, in such a way that a customer uses the transportation facility only if it is helpful. We give algorithms for finding the optimal location of such a transportation facility, where optimality is defined with respect to the maximum travel time between two points in a given set.
Transmitter and Receiver Isolation by Concentric Antenna Structure (2010)

A concentric antenna structure with transmitter (Tx) and receiver (Rx) isolation characteristic is proposed. For both cases that Tx and Rx use the same frequency or different frequencies, Tx leakage can be removed by the proposed antenna structure. The field couplings between antennas are mathematically presented and Tx leakage cancellation is theoretically examined. To theoretically verify the case that Tx and Rx use the same frequency, a set of 16 inverted-F antennas and a set of 4 inverted-F antennas are designed for Tx and Rx, respectively. For the case that Tx and Rx use different frequencies, a set of 4 monopole antennas is designed for Tx and Rx each. The measured result shows the Tx/Rx isolation characteristic of more than -50 dB.