gebhart/patrepeval huggingface dataset:
Quantitative magnetic resonance imaging of capillary water permeability and regional blood volume with an intravascular MR contrast agent (1997)

Abstract A novel method is presented to simultaneously measure the permeability surface area product of water (PS), also known as capillary diffusion capacity, and the regional blood volume (RBV). It is based on magnetic resonance imaging of the longitudinal relaxation times of tissue and blood at different concentrations of an intravascular MR contrast agent. PS and RBV were measured in vivo in different regions of the brain and the skeletal muscle of the rat. The average PS values ( n = 5) obtained in cerebral cortex, corpus callosum, hippocampus, thalamus, jaw muscle, and tongue muscle were 3.31 ± 0.20, 1.81 ± 0.25, 3.37 ± 0.36, 3.68 ± 0.44, 10.6 ± 1.1, and 14.1 ± 2.51 ml ± min −1 ± g −1 , respectively. The corresponding average RBV values were 1.63 ± 0.18,1.22 ± 0.25,3.30 ± 0.37, 3.03 ± 0.36, 1.66 ± 0.30, and 1.38 ± 0.33 ml ± 100g −1 . These results are in good agreement with previously reported literature values obtained by means of autoradiography.
Tissue Factor (Thromboplastin): Localization to Plasma Membranes by Peroxidase-Conjugated Antibodies (1972)

Peroxidase-conjugated antibodies were used to determine the histologic and cytologic localization of bovine and human tissue factor (thromboplastin). Tissue factor antigen was found in highest concentration in the intima of blood vessels, particularly in the plasma membranes of endothelial cells and in human atheromatous plaques. Tissue factor was also found limited to the plasma membranes of many cell types. The presence of tissue factor in the plasma membranes of endothelial cells and atheromata suggests that it may play a significant role in hemostasis and thrombosis.
Escherichia coli genes required for cytochrome c maturation (1995)

The so-called aeg-46.5 region of Escherichia coli contains genes whose expression is induced under anaerobic growth conditions in the presence of nitrate or nitrite as the terminal electron acceptor. In this work, we have examined more closely several genes of this cluster, here designated ccmABCDEFGH, that are homologous to two separate Bradyrhizobium japonicum gene clusters required for the biogenesis of c-type cytochromes. A deletion mutant of E. coli which lacked all of these genes was constructed. Maturation of indigenous c-type cytochromes synthesized under anaerobic respiratory conditions, with nitrite, nitrate, or trimethylamine N-oxide as the electron acceptor, was found to be defective in the mutant. The biogenesis of foreign cytochromes, such as the soluble B. japonicum cytochrome c550 and the membrane-bound Bacillus subtilis cytochrome c550, was also investigated. None of these cytochromes was synthesized in its mature form when expressed in the mutant, as opposed to the situation in the wild type. The results suggest that the E. coli ccm gene cluster present in the aeg-46.5 region is required for a general pathway involved in cytochrome c maturation.
<i>Xenopus</i> polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity (2005)

Metaphase-to-anaphase transition is a fundamental step in cell cycle progression where duplicated sister-chromatids segregate to the future daughter cells. The anaphase-promoting complex/cyclosome (APC/C) is a highly regulated ubiquitin-ligase that triggers anaphase onset and mitotic exit by targeting securin and mitotic cyclins for destruction. It was previously shown that the Xenopus polo-like kinase Plx1 is essential to activate APC/C upon release from cytostatic factor (CSF) arrest in Xenopus egg extract. Although the mechanism by which Plx1 regulates APC/C activation remained unclear, the existence of a putative APC/C inhibitor was postulated whose activity would be neutralized by Plx1 upon CSF release. Here we identify XErp1, a novel Plx1-regulated inhibitor of APC/C activity, and we demonstrate that XErp1 is required to prevent anaphase onset in CSF-arrested Xenopus egg extract. Inactivation of XErp1 leads to premature APC/C activation. Conversely, addition of excess XErp1 to Xenopus egg extract prevents APC/C activation. Plx1 phosphorylates XErp1 in vitro at a site that targets XErp1 for degradation upon CSF release. Thus, our data lead to a model of APC/C activation in Xenopus egg extract in which Plx1 targets the APC/C inhibitor XErp1 for degradation.
Bubble-flux (2013)

Ensuring the quality of service (QoS) for latency-sensitive applications while allowing co-locations of multiple applications on servers is critical for improving server utilization and reducing cost in modern warehouse-scale computers (WSCs). Recent work relies on static profiling to precisely predict the QoS degradation that results from performance interference among co-running applications to increase the number of "safe" co-locations. However, these static profiling techniques have several critical limitations: 1) a priori knowledge of all workloads is required for profiling, 2) it is difficult for the prediction to capture or adapt to phase or load changes of applications, and 3) the prediction technique is limited to only two co-running applications.
Delayed-Onset Primary Cytomegalovirus Disease After Liver Transplantation (2007)

Clinical practice guidelines recommend antiviral prophylaxis to cytomegalovirus (CMV) donor-positive/recipient-negative (D+/R-) liver transplant recipients. We assessed the outcome of this strategy by determining the incidence, clinical features, and risk factors of CMV disease among CMV D+/R- liver transplant recipients who received antiviral prophylaxis. Sixty-seven CMV D+/R- liver transplant recipients (mean age+/-standard deviation: 49.5+/-11.4 years; 75% male) received oral ganciclovir [n=9 (13%)] or valganciclovir [n=58 (87%)] prophylaxis for a median duration of 92 days (interquartile range: 91-100). No breakthrough CMV disease was observed during antiviral prophylaxis. However, primary CMV disease was observed in 2%, 25%, 27%, 27%, and 29% of patients at 1, 3, 6, 12, and 24 months, respectively, after antiviral prophylaxis was stopped. The incidence of delayed-onset primary CMV disease was similar between those who received oral ganciclovir and valganciclovir. Nine (47%) patients had CMV syndrome, 8 (42%) had gastrointestinal CMV disease, and 2 (11%) had CMV hepatitis. Female patients (P=0.01) and younger age at transplant (P=0.03) were associated with an increased risk, whereas diabetes mellitus (P<0.001) was significantly associated with a lower risk of delayed-onset primary CMV disease. Allograft loss or mortality occurred in 8 (12%) patients during the median follow-up period of 3.31 (range: 0.8-5.9) years. No significant association was observed between CMV disease and patient and allograft survival. In conclusion, CMV disease remains a common complication in CMV D+/R- liver transplant patients during the contemporary era of antiviral prophylaxis. Female patients and younger patients are at increased risk of delayed-onset primary CMV disease.
Ranking Cases with Decision Trees: a Geometric Method that Preserves Intelligibility (2005)

This paper proposes a new method to rank the cases classified by a decision tree. The method applies a posteriori without modification of the tree and doesn't use additional training cases. It consists in computing the distance of the cases to the decision boundary induced by the decision tree, and to rank them according to this geometric score. When the data are numeric it is very easy to implement and efficient. The distance-based score is a global assess, contrary to other methods that evaluate the score at the level of the leaf. The distance-based score gives good results even with pruned tree, so if the tree is intelligible this property is preserved with an improved ranking ability. The main reason for the efficacity of the geometric method is that in most cases when the classifier is sufficiently accurate, errors are located near the decision boundary. / Cet article propose une nouvelle méthode pour ordonner des exemples classés par un arbre de décision. Cette méthode s'applique à posteriori sans modification de l'arbre et sans utiliser d'exemples d'apprentissage supplémentaires. Elle consiste à calculer la distance de chaque cas à la frontière de décision crée par l'arbre de décision, puis à ranger les cas suivants ce score géométrique. Quand les données sont numériques, cette méthode est facile à implémenter et très efficace. Le score basé sur la distance est évalué globalement, contrairement à d'autres scores calculés au niveau de chaque feuille. Le score géométrique donne de bons résultats même sur des arbres élagués, donc l'intelligibilité de l'arbre est préservée. La raison principale de l'efficacité de cette méthode géométrique vient du fait que si le classifieur est suffisamment bon, les erreurs sont localisées principalement près de la surface de décision.
Spectral properties of resonant-cavity, polyfluorene light-emitting diodes (2000)

We report on the fabrication and device properties of light-emitting resonant cavity conjugated-polymer diodes. The microcavity structures were constructed using a dielectric mirror, an indium–tin–oxide anode, a green light-emitting polyfluorene blend, and a metal (cathode) mirror. The best performance was obtained for a composite calcium–aluminum cathode, that combines high reflectivity with a low workfunction. This structure emitted electroluminescence with a linewidth of 12 nm and a maximum brightness of 300 cd m−2 at a bias of 35 V with an efficiency of 0.95 cd A−1.
Chapter 13: A New Contour Reconstruction Approach from Dexel Data in Virtual Sculpting (2008)

This paper presents a novel method of contour reconstruction from dexel data solving the shape anomalies for the complex geometry in virtual sculpting. Grouping and traversing processes are developed to find connectivity between dexels along every two adjacent rays. After traveling through all the rays on one slice, sub-boundaries are connected into full boundaries which are desired contours. The complexity of the new method has been investigated and determined as O(n). We also demonstrate the ability of the described method for viewing a sculpted model from different directions.
The autoregulatory role of EsaR, a quorum‐sensing regulator in <i>Pantoea stewartii</i> ssp. <i>stewartii</i>: evidence for a repressor function (2002)

Capsular polysaccharide synthesis and virulence in the plant pathogenic bacterium Pantoea stewartii ssp. stewartii requires the quorum-sensing regulatory proteins, EsaR and EsaI, and the diffusible inducer N-(3-oxo-hexanoyl)-L-homoserine lactone. Prior mutational studies suggested that EsaR might function as a repressor of quorum sensing in the control of capsular polysaccharide synthesis. Further, a lux box-like palindromic sequence coinciding with the putative -10 element of the esaR promoter suggested a possible negative autoregulatory role for EsaR. This report presents genetic evidence that EsaR represses the esaR gene under inducer-limiting conditions, and that addition of inducer promotes rapid, dose-dependent derepression. DNA mobility-shift assays and analyses by surface plasmon resonance refractometry show that EsaR binds target DNAs in a ligand-free state, and that inducer alters the binding characteristics of EsaR. Physical measurements indicate that the EsaR protein binds N-(3-oxo-hexanoyl)-L-homoserine lactone, in a 1:1 protein:ligand ratio, and that inducer binding enhances the thermal stability of the EsaR protein. These combined genetic and biochemical data establish that EsaR regulates its own expression by signal-independent repression and signal-dependent derepression. Additionally, we provide evidence that EsaR does not govern the expression of the linked esaI gene, thus EsaR has no role in controlling coinducer synthesis.
Enantioselective Epoxidation of Terminal Olefins by Chiral Dioxirane (2001)

[see reaction]. This paper describes an enantioselective epoxidation of terminal olefins using chiral ketone 3 as catalyst and Oxone as oxidant. Up to 85% ee has been obtained.
Rule management and inferencing in relational databases (2002)

To handle facts and rules in a database system, it is desirable to have a uniform representation and manipulation scheme for both. In such a case, rules and data are entered, deleted, updated, and queried in a transparent way. In order to support recursive queries and transitive closure queries, a homogeneous approach is very attractive, since it allows rules to be treated as data in a conventional relational database. To be able to infer information from these rules in addition to the stored data in the database, it is necessary for the rules to be triggered and executed as and when required. The authors discuss these issues and the requirements and features of such a system. They also provide a description of a prototype system developed in a Prolog environment and the core manipulating capabilities and inferencing strategy provided for its proper operation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Improvements to propositional satisfiability search algorithms (1995)

... quickly across a wide range of hard SAT problems than any other SAT tester in the literature on comparable platforms. On a Sun SPARCStation 10 running SunOS 4.1.3 U1, POSIT can solve hard random 400-variable 3-SAT problems in about 2 hours on the average. In general, it can solve hard n-variable random 3-SAT problems with search trees of size O(2 n=18:7 ). In addition to justifying these claims, this dissertation describes the most significant achievements of other researchers in this area, and discusses all of the widely known general techniques for speeding up SAT search algorithms. It should be useful to anyone interested in NP-complete problems or combinatorial optimization in general, and it should be particularly useful to researchers in either Artificial Intelligence or Operations Research.
Computer-Aided Medical Decision Making in Radiotherapy (1977)

Radiotherapy departments are becoming sophisticated in working with computers for isodose computations, treatment machine verifications and administrative and medical records. The next step lies in computer-assisted medical decision making. The logic for a patient's diagnostic work-up and treatment protocol can be stored in a computer. It can then be used as an aid in making the diagnosis, in prescribing the treatment and for quality control. For patients who fit established protocols the computer can select and list treatment using the logic of that protocol. Such a system has been implemented for the postoperative radiotherapy of breast cancer on a trial basis. Its potential usefulness is illustrated by results in 25 consecutive patients. Physician acceptance and costs of the program are under investigation.
Improved Stacking Of Vent Lines Of A Parachute (1992)

New arrangement provides nearly uniform distribution of load among vent lines and points of attachment of vent lines to vent band. New method eliminates large stack height between first and last lines and, just as important, maintains constant stack height between any two adjacent vent lines around entire vent. Distributes loads at vent band more nearly evenly among lines. Adverse concentrations of loads in vent band reduced.
Toxin-neutralizing antibodies protect against Clostridium perfringens-induced necrosis in an intestinal loop model for bovine necrohemorrhagic enteritis (2016)

Although immunization of calves with both native and formaldehyde inactivated toxins resulted in high antibody titers against alpha toxin and perfringolysin O, only antibodies raised against native toxins protect against C. perfringens challenge in an intestinal loop model for bovine necrohemorrhagic enteritis.
Production of Bispecif ic and Trispecific F(ab)2 and F(ab)3 Antibody Derivatives (1998)

Bispecific antibodies (BsAbs) are hybrid molecules designed to combine two antibodies with different specificities. This dual specificity has led to their application in a variety of diagnostic situations that require the crosslinking of two protein surfaces, for example, antigen and detecting agent in lmmunohis-tochemistry or immunoassays. More interestingly, BsAbs have been shown to have considerable therapeutic potential when used as targeting reagents to deliver pharmacological substances (drugs or toxins) or cellular effectors (T-cells, monocytes, or NK cells) to tumor cells (1,2). A relatively new development is the design of BsAbs to deliver chelated radiometals for the diagnostic imaging of tumors and for radioimmunotherapy (1).
A linear regression model to predict the pH of neonatal parenteral nutrition solution (2000)

The pH of neonatal parenteral nutrition solutions can be predicted accurately as a linear function of the solution concentrations of the following seven components: sodium acetate, sodium phosphate, potassium phosphate, potassium acetate, magnesium sulphate, amino acid solution and dextrose. The absolute mean difference between measured pH and predicted pH was 0.04. Applying this method to estimate pH with the interactive properties of computer-based ordering systems could enhance calcium and phosphorus administration to very low birth weight infants.
Die rol van ’n plantkundige in Parke en Ontspanning (1990)

The exceptional wealth of the flora of Southern Africa has been known internationally since the early seventeenth century. However, our floral heritage has been subjected to ever increasing pressure resulting from industrial, urban and agricultural development. Research primarily aimed at conserving our indigenous flora, making rare species available to nurseries as well as establishing a meaningful tree planting programme can, however, be undertaken by Departments of Parks and Recre­ation. Educational programmes ranging from formal to non-formal botanical education can play an important role in making the public aware of our unique flora. A graduate presenting botany as one major subject can assist Departments of Parks and Recreation in utilizing these opportunities, not only to conserve, but also to develop the natural resources currently under their control.
Inversion of refraction data by wave field continuation (1981)

Abstract The process of wave equation continuation (migration) is adapted for refraction data in order to produce velocity-depth models directly from the recorded data. The procedure consists of two linear transformations: a slant stack of the data produces a wave field in the p - tau plane which is then downward continued using tau = 0 as the imaging condition. The result is that the data wave field is linearly transformed from the time-distance domain into the slowness-depth domain, where the velocity profile can be picked directly. No traveltime picking is involved, and all the data are present throughout the inversion.The method is iterative because it is necessary to specify a velocity function for the continuation. The solution produced by a given iteration is used as the continuation velocity function for the next step. Convergence is determined when the output wave field images the same velocity-depth function as was input to the continuation.The method obviates the problems associated with determining the envelope of solutions that are consistent with the observations, since the time resolution in the data is transformed into a depth resolution in the slowness-depth domain.The method is illustrated with several synthetic examples, and with a refraction line recorded in the Imperial Valley, California.
Drill-bit displacement-source model: Source performance and drilling parameters (2006)

Abstract The emission properties of a drill-bit source and the signature of the drill-bit seismograms depend on the dynamic action of the drill bit, which in turn is a function of the geological conditions, rock properties, and drilling parameters. In fact, drilling is a variable dynamic process, in which the vibrations produced by the drill bit are transmitted into the drillstring and formation with a partition of energy determined by the impedances at the bit. In this analysis, we study drill-bit performance and calculate the forces produced by an ideal drill bit to determine the variations in the signal signature and, ultimately, the conditions of source repeatability as a function of average drilling parameters and signal frequency. The model includes near-field effects and assumes the drill bit acts as a displacement source, producing axial bit forces with relative bit/formation displacement and vertical penetration in the formation. The analysis shows that the expected bit signature, which is equivalent to the ground force in Vibroseis, depends on average tooth impact area, percussion frequency, rate of penetration, formation strength, bit wear, and downhole pressure. In particular, the results show that larger amplitudes of the axial forces are expected at a lower rate of penetration, higher formation strength, and lower formation pressure.
Association of SNP rs17465637 on Chromosome 1q41 and rs599839 on 1p13.3 with Myocardial Infarction in an American Caucasian Population (2011)

Recent genome-wide single nucleotide polymorphism (SNP) association studies (GWAS) have identified a number of SNPs that were significantly associated with coronary artery disease and myocardial infarction (MI). However, many independent replication studies in other populations are needed to unequivocally confirm the GWAS association. To assess GWAS association, we have established a case-control cohort consisting of 1231 well-characterised MI patients and 560 controls without detectable coronary stenosis, all selected from the Cleveland Genebank population. The Genebank cohort has sufficient power to detect the association between MI and four GWAS SNPs, including rs17465637 within the MIA3 gene, rs2943634 (intergenic), rs6922269 in MTHFD1L, and rs599839 near SORT1. SNPs were genotyped by TaqMan assays and follow-up multivariate logistic regression analysis with incorporation of significant covariates showed significant association with MI for MIA3 SNP rs17465637 (P-adj= 0.0034) and SORT1 SNP rs599839 (P-adj= 0.009). The minor allele G of rs599839 was also associated with a decreased LDL-C level of 5-9 mg/dL per allele, but not with HDL-C or triglyceride levels. No association for MI or lipid levels was found for SNPs rs2943634 and rs6922269 (P-adj > 0.05). Our results establish two SNPs, rs17465637 in MIA3 and rs599839 near SORT1 as significant risk factors for MI in the American Genebank Caucasian population.
Prime-phase sequences with periodic correlation properties better than binary sequences (1991)

For the case where p is an odd prime, n>or=2 is an integer, and omega is a complex primitive pth root of unity, a construction is presented for a family of p/sup n/ p-phase sequences (symbols of the form omega /sup i/), where each sequence has length p/sup n/-1, and where the maximum nontrivial correlation value C/sub max/ does not exceed 1+ square root p/sup n/. A complete distribution of correlation values is provided. As a special case of this construction, a previous construction due to Sidelnikov (1971) is obtained. The family of sequences is asymptotically optimum with respect to its correlation properties, and, in comparison with many previous nonbinary designs, the present design has the additional advantage of not requiring an alphabet of size larger than three. The new sequences are suitable for achieving code-division multiple access and are easily implemented using shift registers. They wee discovered through an application of Deligne's bound (1974) on exponential sums of the Weil type in, several variables. The sequences are also shown to have strong identification with certain bent functions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>