gebhart/patrepeval huggingface dataset:
Large-scale molecular mapping of human c-myb locus: c-myb proto-oncogene is not involved in 6q- abnormalities of lymphoid tumors. (1992)

Chromosomal abnormalities in the 6q region have been observed frequently in several T-cell and myeloid leukemias. Interestingly, this region was found to contain three cellular oncogenes, c-myb, c-fyn and c-ros. Several of the tumors that exhibit 6q- abnormalities have also been found to express high levels of c-myb and, in some cases, amplification of the c-myb gene, leading to the suggestion that this gene could lie in proximity to the deletions observed in these tumors. To determine if c-myb gene activation is associated with 6q- abnormalities, we developed a megabase map of the human c-myb locus using pulsed-field gel electrophoresis. We then examined the occurrence of abnormalities near the c-myb gene in several hematopoietic tumor cell lines containing well-characterized 6q- abnormalities. Our results show that no rearrangements or deletions occur within a region of 1.0 Mbp of the c-myb locus in these cell lines. However, several of the cell lines exhibited differential and partial methylation patterns which seem to be prevalent amongst different cell lines.
Distributed-Feedback Ring All-Fiber Laser (1996)

Continuous-wave, low-threshold and 6.5 kHz linewidth single longitudinal mode operation is achieved in a nove1 distributed-feedback (DFB) ring all-fiber laser configuration, using an Er3+/Yb3+-doped phosphosilicate fiber. Self-Q-switching due to saturable absorption has also been observed in the DFB ring configuration using a heavily erbium doped germanosilicate fiber.
Low-complexity signal detection based on relaxation iteration method in massive MIMO systems (2015)

Minimum mean square error (MMSE) detection algorithm can achieve nearly optimal performance when the number of antennas at the base station (BS) is large enough compared to the number of users. But the traditional MMSE involves complicated matrix inversion. In this paper, we propose a modified MMSE algorithm which exploits the channel characteristics occurring in massive multiple-input multiple-output (MIMO) channels and the relaxation iteration (RI) method to avoid the matrix inversion. A proper initial solution is given to accelerate the convergence speed. In addition, we point out that the channel estimation scheme used in channel hardening-exploiting message passing (CHEMP) receiver is very appropriate for our proposed detection algorithm. Simulation results verify that the proposed algorithm can achieve very close performance of the traditional MMSE algorithm with a small number of iterations.
Subnanosecond fluorescence waveforms measurements with a dual time-scale microprocessor-controlled averager (1981)

This paper presents a microprocessor-controlled apparatus for the measurement of fast fluorescence waveforms. This apparatus features a dual-time scale for the analysis of multiexponential decays. A sampling oscilloscope is used as the sampling device. The sampling time is externally controlled by means of a staircase reference voltage. The dual-time scale is obtained by enhancing the density of sampled points in a time window corresponding to the faster portion of the waveform. The slow vertical output of the sampling oscilloscope is digitized, and numerical averaging is performed in order to improve the signal-to-noise ratio. An on-line display of the measured waveform and a connection with a host computer for further data processing are also provided. Details of the hardware and software structure are given, together with applicable examples.
The product of the <i>pilQ</i> gene is essential for the biogenesis of type IV pili in <i>Neisseria gonorrhoeae</i> (1995)

The product of the Neisseria gonorrhoeae omc gene possesses regions homologous to those found in members of a protein superfamily that are associated with the translocation of proteins and DNA-protein complexes across the outer membrane. Amongst its protein homologues, Omc has higher overall homology to PilQ, which is required for type IV pilus expression in Pseudomonas aeruginosa, and OrfE, which is required for sequence-specific DNA uptake by Haemophilus influenzae. The function of Omc, however, is unknown and gonococcal omc mutants have not been described. We constructed gonococcal mutants expressing truncated forms of the protein, and found that these mutants are severely defective for both pilus expression and competence for natural transformation. To be consistent with pre-existing pilus gene nomenclature, we have redesignated the gene pilQ instead of omc, and its product, PilQ instead of Omc. The MS11 gene was sequenced and found to differ from the DNA sequence reported for that of another gonococcal strain; these differences were associated with a repeated DNA element, suggesting a genetic basis for structural variation in PilQ. The results also show that PilQ- mutants are distinct from previously described gonococcal pilus-assembly mutants and P. aeruginosa PilQ- mutants by virtue of their expression of rare pilus filaments. Taking these data into account, PilQ is proposed to function in the terminal steps of organelle biogenesis by acting as a pilus channel or pore.
Water Analysis: Emerging Contaminants and Current Issues (2015)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTWater Analysis: Emerging Contaminants and Current IssuesSusan D. Richardson* and Susana Y. KimuraView Author Information Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States*E-mail: [email protected]Cite this: Anal. Chem. 2016, 88, 1, 546–582Publication Date (Web):November 30, 2015Publication History Published online14 December 2015Published inissue 5 January 2016https://pubs.acs.org/doi/10.1021/acs.analchem.5b04493https://doi.org/10.1021/acs.analchem.5b04493review-articleACS PublicationsCopyright © 2015 American Chemical SocietyRequest reuse permissionsArticle Views12042Altmetric-Citations344LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chlorine,Drinking water,Impurities,Pharmaceuticals,Wastewater Get e-Alerts
Recent Advances in Near‐Infrared Absorption Nanomaterials as Photoacoustic Contrast Agents for Biomedical Imaging (2014)

Abstract Photoacoustic imaging (PAI) is an emerging whole‐body imaging modality offering high spatial resolution, deep penetration and high contrast in vivo . Signals for PAI are generated from contrast agents, where the laser‐generated optical energy is transferred to acoustic emissions and detected by an ultrasound transducer. A great deal of research over the past ten years has shown that near‐infrared absorption nanomaterials such as organic dye‐based nanoparticals, polymer‐based nanoparticles, carbon‐based nanomaterials and metallic nanomaterials are promising photoacoustic (PA) contrast agents, which can increase the imaging resolution, contrast and depth of detection. Hence, it is an attractive research field to develop new PA contrast agents. Herein, we reviewed this rapidly growing field and described the applications of nanomaterial‐based PA contrast agents for biomedical imaging. Particular focus was given to organic near‐infrared absorbing dyes including cyanine, porphyrin and boron‐dipyrromethene derivatives.
Toward Truly Water‐Soluble Rodlike Polyelectrolytes: Synthesis of Poly(<i>para</i>‐phenylenes) Wrapped in Ethylene Oxideand Amino Side Groups (2016)

Suzuki and Yamamoto cross‐coupling protocols are applied to synthesize water‐soluble poly( p ‐phenylene) (PPP) derivatives decorated with oligoethylene oxide (OEO) and tertiary amino side groups. It is shown that constitutionally well‐defined PPPs can be obtained having degrees of polycondensation, P n , of 30–60. In some cases, however the heteroatoms in the side chains affect the monomer synthesis and prevent proper chain growth through coordination of metal species present in the reaction medium. It is shown that essentially uncharged but still water‐soluble PPPs result if ( i ) the side groups bear their heteroatoms in the right position, and ( ii ) if the water‐soluble segments of the lateral substituents prevent intermolecular hydrophobic interactions of the apolar main chains reliably. In other words, the lateral substituents have to wrap the PPP core structure tightly in a closed outer shell of water‐soluble OEO moieties. These PPPs constitute a valuable new pool of model systems for future polyelectrolyte research, being highly complementary to what has been available so far. image
Microstructure of Plasma-Sintered Aluminum Bronze Powder Compacts (2006)

Porous materials are successfully utilized for fabrication of many industrial components such as filters and selflubricating bearings. These products are made by powder metallurgy, where mixtured or prealloyed powders can be used. The aluminum bronze is one of the most wanted due its excellent properties in combination with low cost of the raw materials. In this work, single action compacted (100 MPa) prealloyed aluminum bronze (Cu- 9wt%Al-1wt%Fe) cylinders were sintered using a hollow cathode discharge at temperatures between 400 and 750°C with duration on the isotherm for 12 min. Microstructure changes, homogeneity, porosity and composition were analyzed after the treatment. Sintering below 550° C led to uniform but porous structure. Above 550 °C it was observed a solidified central region and a porous structure that changes slightly through out the cross-section. The diameter of the central region increased with treatment temperature. It is concluded that due to the intense plasma heating and subsequent surface melt formation a mass flow direction to the center of compacts occurred.
<title>Photomultiplier Linearization And System Stabilization For Photometric Ellipsometers And Polarimeters</title> (1977)

Modifications to standard photometric polarimeter systems that reduce measurement errors due to drift, digital noise, and stray light are described. For instruments using photo-multiplier (PM) detectors, a regulation and control circuit is discussed that also allows the linearity of the detector to be adjusted. The measured performance of a rotating-analyzer ellipsometer (RAE) using these modifications is as follows: Linearity to 5x10-4 over more than three orders of magnitude of incident light intensity, and stability to 5x10-5.
Bringing People and Places Together (1998)

This paper describes initial work on the Domisil-ica project at Georgia Tech. We are exploring the dual augmentation of physical and virtual worlds in Domisilica nd applying this novel concept to support home life beyond the boundaries of the actual house. We will demonstrate the concepts of dual augmentation through one particular ap-pliance, CyberFridge, which serves as an inven-tory management and communications link be-tween physical and virtual worlds. Keywords- &quot; Augmented reality, augmented virtual-ity, home, ubiquitous computing
Avidity Binding of Human Adenovirus Serotypes 3 and 7 to the Membrane Cofactor CD46 Triggers Infection (2011)

The species B human adenoviruses (HAdVs) infect cells upon attaching to CD46 or desmoglein 2 (DSG-2) by one or several of their 12 fiber knob trimers (FKs). To test whether DSG-2 and CD46 simultaneously serve as virus receptors for adenovirus type 3 (Ad3), we performed individual and combined CD46/DSG-2 loss-of-function studies in human lung A549 and 16HBE14o cells. Our results suggest that in these cells, DSG-2 functions as a major attachment receptor for Ad3, whereas CD46 exerts a minor contribution to virus attachment and uptake in the range of ∼10%. However, in other cells the role of CD46 may be more pronounced depending on, e.g., the expression levels of the receptors. To test if avidity allows Ad3/7 to use CD46 as a receptor, we performed gain-of-function studies. The cell surface levels of ectopically expressed CD46 in CHO or human M010119 melanoma cells lacking DSG-2 positively correlated with Ad3/7 infections, while Ad11/35 infections depended on CD46 but less on CD46 levels. Antibody-cross-linked soluble CD46 blocked Ad3/7/11/35 infections, while soluble CD46 alone blocked Ad11/35 but not Ad3/7. Soluble Ad3/7-FKs poorly inhibited Ad3/7 infection of CHO-CD46 cells, illustrating that Ad3/7-FKs bind with low affinity to CD46. This was confirmed by Biacore studies. Ad3/7-FK binding to immobilized CD46 at low density was not detected, unlike that of Ad11/35-FK. At higher CD46 densities, however, Ad3/7-FK bound to CD46 with only 15-fold-higher dissociation constants than those of Ad11/35-FK. These data show that an avidity mechanism for Ad3/7 binding to CD46 leads to infection of CD46-positive cells.
A review of state‐of‐the‐art large‐sized foam cutting rapid prototyping and manufacturing technologies (2010)

Purpose Current additive rapid prototyping (RP) technologies fail to efficiently produce objects greater than 0.5 m 3 due to restrictions in build size, build time and cost. A need exists to develop RP and manufacturing technologies capable of producing large objects in a rapid manner directly from computer‐aided design data. Foam cutting RP is a relatively new technology capable of producing large complex objects using inexpensive materials. The purpose of this paper is to describe nine such technologies that have been developed or are currently being developed at institutions around the world. The relative merits of each system are discussed. Recommendations are given with the aim of enhancing the performance of existing and future foam cutting RP systems. Design/methodology/approach The review is based on an extensive literature review covering academic publications, company documents and web site information. Findings The paper provides insights into the different machine configurations and cutting strategies. The most successful machines and cutting strategies are identified. Research limitations/implications Most of the foam cutting RP systems described have not been developed to the commercial level, thus a benchmark study directly comparing the nine systems was not possible. Originality/value This paper provides the first overview of foam cutting RP technology, a field which is over a decade old. The information contained in this paper will help improve future developments in foam cutting RP systems.
Chemotherapy for hepatocellular carcinoma: The present and the future (2017)

Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver. Its relationship to chronic liver diseases, in particular cirrhosis, develops on a background of viral hepatitis, excessive alcohol intake or metabolic steatohepatitis, leads to a high incidence and prevalence of this neoplasia worldwide. Despite the spread of HCC, its treatment it's still a hard challenge, due to high rate of late diagnosis and to lack of therapeutic options for advanced disease. In fact radical surgery and liver transplantation, the most radical therapeutic approaches, are indicated only in case of early diagnosis. Even local therapies, such as transarterial chemoembolization, find limited indications, leading to an important problem regarding treatment of advanced disease. In this situation, until terminal HCC occurs, systemic therapy is the only possible approach, with sorafenib as the only standard treatment available. Anyway, the efficacy of this drug is limited and many efforts are necessary to understand who could benefit more with this treatment. Therefore, other molecules for a targeted therapy were evaluated, but only regorafenib showed promising results. Beside molecular target therapy, also cytotoxic drugs, in particular oxaliplatin- and gemcitabine-based regimens, and immune-checkpoint inhibitors were tested with interesting results. The future of the treatment of this neoplasia is linked to our ability to understand its mechanisms of resistance and to find novel therapeutic targets, with the objective to purpose individualized approaches to patients affected by advanced HCC.
A Review of Load Forecasting of the Distributed Energy System (2019)

With the development of global intelligence industry and new energy systems, the role of load forecasting is increasingly prominent. This article reviews the research progress and applications of load forecasting technology. How to improve the accuracy and speed of load forecasting is the current research hotspot, and this paper comprehensively summarizes the influencing factors for the performance of load forecasting such as various input parameters and load forecasting models. Besides, this paper reviews evaluation indicators of load forecasting, three different sizes' buildings as typical cases. Finally, three research trends in this field are summed up: deep learning, predictive measurement, and combination with occupant behavior prediction.
Selection of attenuated phase shift mask compatible contact hole resists for KrF optical lithography (1999)

Multiple contact hole resist samples from a variety of DUV resist suppliers, including both acetal and ESCAP chemistries are evaluated on an organic anti-reflective under layer (ARC) using an attenuated phase shift mask (APSM). One sample exhibited excellent surface inhibition and superior lithographic performance for patterning contact holes of 0.2 micrometers imaging size. For most of resists, the process windows are limited by unwanted sidelobe printing through focus. The sensitivity of sidelobe printing to focus can be attributed to lens aberrations. For the first time, we prose to use Depth-of-focus (DOF) loss PWL<SUB>dof</SUB> and Exposure latitude (EL) loss PWL<SUB>el</SUB> to characterize resists surface inhibition, as well discovered that DOF loss is a sensitive measure of surface inhibition. Similar lithographic performance is obtained from acetal and ESCAP based materials. The two ESCAP resists EB3 and EA2 have better oxide etch resistance than the acetal resist AC1. The top surface reticulation is observed on ESCAP resist EB3 and EA2 during the oxide etch, but not on the acetal resist AC1. 110 nm underexposed resolutions achieved with the resist EA4 at a mask size of 250 nm. Faster resists generally exhibit better resolution but have smaller process windows when side lobe printing is included as a criterion. Selection of a resist formulation for attenuated phase shift applications has to face a compromise between resolution, photospeed, process window and surface inhibition. Finally, ARC operational modes and optical properties had little effect on sidelobe printing, and optimization of PEB temperature is important in suppressing sidelobe printing.
Effects of acetazolamide on the sleep apnea syndrome and its therapeutic mechanism (1995)

Twenty male patients with sleep apnea syndrome were treated with acetazolamide (AZM), a carbonic anhydrase inhibitor. In 14 of the patient a significant decrease was found in the number of apnea, apnea index and % apnea time (percentage of time spent with apnea to the total sleep time) with improvement in sleep structure, clinical symptoms, such as insomnia, daytime excessive sleepiness and snoring. A significant decrease was also observed in arterial blood pH and HCO-3 in the 14 improved patients. On the other hand, no improvement occurred in the parameters of sleep apnea and sleep with AZM in the remaining six patients. Moreover, metabolic acidosis and an improvement in arterial blood gases did not occur with AZM in the six patients.
Capturing H<sub>2</sub>S<sub>(g)</sub>by In Situ-Prepared Ultradispersed Metal Oxide Particles in an Oilsand-Packed Bed Column (2010)

The current oil recovery and upgrading processes contribute directly to air pollution problems. H2S(g) is considered one of the major gaseous pollutants in oil recovery and processing. The aim of this study is to investigate the feasibility of methods aimed at the in situ capture of H2S(g) and its conversion into an environmentally neutral final product. In this work, we tested the sorption of H2S(g) into different in situ-prepared colloidal metal oxides in an oilsand matrix under recovery conditions, namely, ZnO, CuO, NiO, and Al2O3. In addition, the effect of metal oxide concentration and reaction temperature on H2S(g) reactivity was evaluated. Furthermore, commercially available ZnO nanoparticles were tested for comparison. Except for Al2O3, all the considered metal oxides reacted stoichiometrically with H2S(g) at the selected temperature and pressure. An increase in the metal oxide concentration favored the removal of H2S(g). The in situ-prepared ZnO ultradispersed particles were found to be more reactive than the commercial nanoparticles, as a result of their dispersion ability and intrinsic reactivity.
Experimental Behavior of Carbon Fiber-Reinforced Polymer (CFRP) Sheets Attached to Concrete Surfaces Using CFRP Anchors (2010)

Fiber-reinforced polymer (FRP) composite sheets have gained popularity as a viable strengthening technique for existing reinforced concrete structures. The efficiency of the strengthening system largely depends on adequate bond between FRP sheets and the concrete substrate. In recent years, techniques to anchor FRP sheets have been proposed in applications that have limited distance to develop FRP sheet strength. One promising technique consists of fabricating and bonding FRP anchors during the FRP sheet saturation and embedding them into predrilled holes in the concrete substrate. This paper presents experimental results highlighting the complex behavior between FRP sheets and anchors. The primary failure modes that the sheet-anchor system can experience are identified. The experiments identify the main variables that influence the FRP anchor-sheet system behavior. This research contributes to the needed experimental database that will aid in future development of design recommendations of this anchorage system.
Compressive 3D ultrasound imaging using a single sensor (2017)

Three-dimensional ultrasound is a powerful imaging technique, but it requires thousands of sensors and complex hardware. Very recently, the discovery of compressive sensing has shown that the signal structure can be exploited to reduce the burden posed by traditional sensing requirements. In this spirit, we have designed a simple ultrasound imaging device that can perform three-dimensional imaging using just a single ultrasound sensor. Our device makes a compressed measurement of the spatial ultrasound field using a plastic aperture mask placed in front of the ultrasound sensor. The aperture mask ensures that every pixel in the image is uniquely identifiable in the compressed measurement. We demonstrate that this device can successfully image two structured objects placed in water. The need for just one sensor instead of thousands paves the way for cheaper, faster, simpler, and smaller sensing devices and possible new clinical applications.