gebhart/patrepeval huggingface dataset:
Advanced cuttings analysis provides improved completion design, efficiency and well production (2016)

R ecent case studies of lateral well completions have highlighted the apparent ineffectiveness of geometric stage performance with regards to fracture initiation and stimulated reservoir volume (Far et al., 2015; Ashton et al., 2013; Ganguly and Cipolla, 2012). It has been observed that poor stage performance can be attributed to varying rock type compositions along the borehole, due to lateral facies changes and/or wellbore porpoising. The inefficiencies linked to non or poor performing stages can result in higher costs, associated with equipment and materials, and limit the production potential of wells. This case study highlights how the application of an optimized hydraulic fracture stimulation plan, by honouring lateral well geological heterogeneities, improved completion efficiency and well production within the Cleveland Sandstone formation, Oklahoma, USA. Optimized completions Designing optimized hydraulic fracture stimulation in a lateral well requires an understanding of the near-well bore geomechanical properties and the near-well bore and farfield stresses along the entire lateral. Such reservoir characterization is normally developed from geomechanical and petrophysical analyses using wireline or logging-while-drilling (LWD) services that include acoustic and borehole- image logs. Unfortunately, economic considerations can often inhibit or prohibit the use of logging techniques and hence the complete characterization of the reservoir, especially in the current low oil and gas price environment. A practical and convenient alternative for reservoir characterization is to use the commonly available cuttings samples to provide gross characterization of a vertical or lateral well. Utilizing Automated Mineralogy (AM) techniques, such as CGG’s RoqSCANTM, (Ashton et al., 2013) provides comprehensive data from these cuttings which includes mineralogy, texture and rock properties throughout the entire length of the well. RoqSCAN analysis can be performed either in the laboratory or at the well site to provide near-real-time reservoir navigation and data to optimize the design of completions that will be performed soon after the well reaches total depth (TD).
<i>PTEN</i> Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR (2009)

Clinical resistance to epidermal growth factor receptor (EGFR) inhibition in lung cancer has been linked to the emergence of the EGFR T790M resistance mutation or amplification of MET. Additional mechanisms contributing to EGFR inhibitor resistance remain elusive. By applying combined analyses of gene expression, copy number, and biochemical analyses of EGFR inhibitor responsiveness, we identified homozygous loss of PTEN to segregate EGFR-dependent and EGFR-independent cells. We show that in EGFR-dependent cells, PTEN loss partially uncouples mutant EGFR from downstream signaling and activates EGFR, thereby contributing to erlotinib resistance. The clinical relevance of our findings is supported by the observation of PTEN loss in 1 out of 24 primary EGFR-mutant non-small cell lung cancer (NSCLC) tumors. These results suggest a novel resistance mechanism in EGFR-mutant NSCLC involving PTEN loss.
Tactile identification of objects using Bayesian exploration (2013)

In order to endow robots with human-like tactile sensory abilities, they must be provided with tactile sensors and intelligent algorithms to select and control useful exploratory movements and interpret data from all available sensors. Current robotic systems do not possess such sensors or algorithms. In this study we integrate multimodal tactile sensing (force, vibration and temperature) from the BioTac® with a Shadow Dexterous Hand and program the robot to make exploratory movements similar to those humans make when identifying objects by their compliance, texture, and thermal properties. Signal processing strategies were developed to provide measures of these perceptual properties. When identifying an object, exploratory movements are intelligently selected using a process we have previously developed called Bayesian exploration [1], whereby exploratory movements that provide the most disambiguation between likely candidates of objects are automatically selected. The exploration algorithm was augmented with reinforcement learning whereby its internal representations of objects evolved according to its cumulative experience with them. This allowed the algorithm to compensate for drift in the performance of the anthropomorphic robot hand and the ambient conditions of testing, improving accuracy while reducing the number of exploratory movements required to identify an object. The robot correctly identified 10 different objects on 99 out of 100 presentations.
Structural Basis for the Exocellulase Activity of the Cellobiohydrolase CbhA from <i>Clostridium thermocellum</i> (2004)

Numerous bacterial and fungal organisms have evolved elaborate sets of modular glycoside hydrolases and similar enzymes aimed at the degradation of polymeric carbohydrates. Presently, on the basis of sequence similarity catalytic modules of these enzymes have been classified into 90 families. Representatives of a particular family display similar fold and catalytic mechanisms. However, within families distinctions occur with regard to enzymatic properties and type of activity against carbohydrate chains. Cellobiohydrolase CbhA from Clostridium thermocellum is a large seven-modular enzyme with a catalytic module belonging to family 9. In contrast to other representatives of that family possessing only endo- and, in few cases, endo/exo-cellulase activities, CbhA is exclusively an exocellulase. The crystal structures of the combination of the immunoglobulin-like module and the catalytic module of CbhA (Ig-GH9_CbhA) and that of an inactive mutant Ig-GH9_CbhA(E795Q) in complex with cellotetraose (CTT) are reported here. The detailed analysis of these structures reveals that, while key catalytic residues and overall fold are conserved in this enzyme and those of other family 9 glycoside hydrolases, the active site of GH9_CbhA is blocked off after the -2 subsite. This feature which is created by an extension and altered conformation of a single loop region explains the inability of the active site of CbhA to accommodate a long cellulose chain and to cut it internally. This altered loop region is responsible for the exocellulolytic activity of the enzyme.
Factors Influencing Coexistence of Toenail Onychomycosis With Tinea Pedis and Other Dermatomycoses (2006)

The coexistence of toenail onychomycosis with other types of fungal skin infections is a frequent phenomenon. It could be hypothesized that infected toenails may be a site from which the fungal infections could spread to other body areas. Effective therapy for onychomycosis might therefore be essential not only to treat the lesional toenails but also to prevent spreading the infection to other sites of the skin.
A multipeptide vaccine plus toll-like receptor agonists LPS or polyICLC in combination with incomplete Freund’s adjuvant in melanoma patients (2019)

The clinical trial Mel58 was performed with IRB (#15781) and FDA approval and is registered with Clinicaltrials.gov on April 25, 2012 (NCT01585350). Patients provided written informed consent to participate. Enrollment started on June 24, 2012.
Laser-Beam-Patterned Topological Insulating States on Thin Semiconducting <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi>MoS</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (2019)

Identifying the two-dimensional (2D) topological insulating (TI) state in new materials and its control are crucial aspects towards the development of voltage-controlled spintronic devices with low-power dissipation. Members of the 2D transition metal dichalcogenides have been recently predicted and experimentally reported as a new class of 2D TI materials, but in most cases edge conduction seems fragile and limited to the monolayer phase fabricated on specified substrates. Here, we realize the controlled patterning of the 1T^{'} phase embedded into the 2H phase of thin semiconducting molybdenum-disulfide by laser beam irradiation. Integer fractions of the quantum of resistance, the dependence on laser-irradiation conditions, magnetic field, and temperature, as well as the bulk gap observation by scanning tunneling spectroscopy and theoretical calculations indicate the presence of the quantum spin Hall phase in our patterned 1T^{'} phases.
MetaRoute: fast search for relevant metabolic routes for interactive network navigation and visualization (2008)

Supplementary details are available at http://www-bs.informatik.uni-tuebingen.de/Services/MetaRoute.
Mobilization of CD133<sup>+</sup>CD34<sup>−</sup> cells in healthy individuals following whole‐body acupuncture for spinal cord injuries (2009)

Acupuncture can alleviate symptoms of spinal cord injuries (SCI). The underlying mechanism, however, is unknown. We hypothesized that stem cells could be mobilized by acupuncture. Therefore, we enrolled 14 healthy study participants using acupuncture points for the treatment of SCI. The frequency of CD133 and CD34 cells in peripheral blood and the serum concentrations of matrix metalloproteinase (MMP)-9, brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and interleukin-6 were determined before and after acupuncture (<1 hr, 24 hr, and 48 hr). CD133(+)34(-) cells were doubled 48 hr after acupuncture, with concomitant decreases in BDNF and MMP-9 levels. Interleukin-6 remained below detectable levels, eliminating a stress-induced cell release. Individuals acupunctured on control counterpoints showed no changes in CD133(+) cells. Our results indicate that acupuncture for SCI can mobilize human CD133(+)34(-) cells. (c) 2009 Wiley-Liss, Inc.
A Solid Phase Radioimmunoassay for the Measurement of Free Thyroxine: A New Screening Test for Thyroid Function? (1983)

A solid phase radioimmunoassay for the measurement of free thyroxine, utilizing immunoextraction of free T4, was evaluated for its clinical utility and compared to the free thyroxine indices obtained by the measurement of thyroxine-binding globulin (TBG) or assessment of TBG by talc T3 uptake (TT3U) and total T4 (FTI-1 = total T4/TBG and FT1-2 = Total T4 × TT3U). Free T4, FTI-1, and FTI-2 were analyzed in a total of 202 specimens: 62 normal healthy subjects, 40 hypothyroid, 11 hyperthyroid, 63 euthyroid, 16 euthyroid women on oral contraceptives, seven euthyroid pregnant women, two euthyroid patients with TBG deficiency, and one euthyroid patient with an excessive increase in TBG. Also, free T4 and FTI-2 were measured in nine patients with nonthyroidal illnesses who had decreased triiodothyronine and total T4 levels. Free T4 assay was simple and rapid but showed poor precision. Also, it was less sensitive for detecting hypothyroidism (sensitivity 75%) as compared to FTI-1 and FTI-2 (sensitivity, 95% and 90%, respectively) and, therefore, is not recommended for screening purposes. This test, however, seems to be helpful in confirming the diagnosis of hyperthyroidism in occasional patients with high normal FTI levels as well as for ruling out hypothyroidism in patients with nonthyroidal illnesses.
Improving virtual function call target prediction via dependence-based pre-computation (1999)

We introduce dependence-based pre-computation as a complement to history-based target prediction schemes. We present pre-computation in the context of virtual finction calls (v-calls), a class of control transfers that is becoming increasingly important and has resisted conventional prediction.
Outwardly Rectifying Tonically Active GABA <sub>A</sub> Receptors in Pyramidal Cells Modulate Neuronal Offset, Not Gain (2009)

Hippocampal pyramidal cell excitability is regulated both by fast synaptic inhibition and by tonically active high-affinity extrasynaptic GABA(A) receptors. The impact of tonic inhibition on neuronal gain and offset, and thus on information processing, is unclear. Offset is altered by shunting inhibition, and the gain of a neuronal response to an excitatory input can be modified by changing the level of "background" synaptic noise. Therefore, tonic activation of GABA(A) receptors would be expected to modulate offset and, in addition, to alter gain through a shunting effect on synaptic noise. Here we show that tonically active GABA(A) receptors in CA1 pyramidal cells show marked outward rectification, while the peaks of IPSCs exhibit a linear current-voltage relationship. As a result, tonic GABA(A) receptor-mediated currents have a minimal effect upon subthreshold membrane potential variation due to synaptic noise, but predominantly affect neurons at spiking threshold. Consistent with this, tonic GABA(A) receptor-mediated currents in pyramidal cells exclusively affect offset and not gain. Modulation of tonically active GABA(A) receptors by fluctuations in extracellular GABA concentrations or neuromodulators acting on high-affinity receptors potentially provides a powerful mechanism to alter neuronal offset independently of neuronal gain.
2,5,5-Trimethylthiazolidine-4-carboxylic acid, a D(-)-penicillamine-directed pseudometabolite of ethanol. Detoxication mechanism for acetaldehyde (1978)

A directed detoxication mechanism for acetaldehyde (AcH) is described wherein ethanol-derived AcH, circulating in the blood of rats given ethanol-1-14C and disulfiram or pargyline, was sequestered by condensation with administered D(-)-penicillamine (1). The product of this condensation, 2,5,5-trimethylthiazolidine-4-carboxylic acid (3), which was excreted in the urine without acetyl conjugation, was quantitatively determined by inverse isotope dilution measurements. Acetylation of the urine permitted the isolation of the corresponding N-acetyl derivative in crystalline form. The chirality of 3 was deduced by NMR analysis to be 72% 2S, 4S and 28% 2R, 4S. Although acetylation selectively acetylated the predominant isomer, this acetylated derivative was identical in all respects with a chemically synthesized product. This suggests that the in vivo condensation of AcH and 1 is not enzyme mediated.
Balloon Rupture During Coronary Angioplasty (1986)

Out of a total of 1,500 percutaneous coronary angioplasties (PTCA), 55 (3.6%) were associated with balloon rupture. Lesion calcification was noticed in 7 of these 55 patients (12.7%). Balloon rupture occurred at a mean pressure of 10.7 atmospheres. All balloons were retrieved without difficulty. Intimal tears were noted in 18 (32.7%) cases. Three patients required bypass surgery. In 29 patients restudied angiographically, the restenosis rate was 38%. Balloon rupture during PTCA does not seem to be associated with detrimental consequences.
Direct electron transfer to Escherichia coli fumarate reductase in self-assembled alkanethiol monolayers on gold electrodes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect electron transfer to Escherichia coli fumarate reductase in self-assembled alkanethiol monolayers on gold electrodesKathleen T. Kinnear and Harold G. MonbouquetteCite this: Langmuir 1993, 9, 9, 2255–2257Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/la00033a002https://doi.org/10.1021/la00033a002research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A re‐examination of the epstein‐barr virus carrier state in healthy seropositive individuals (1985)

A panel of 24 healthy seropositive donors have been followed prospectively over a period of 15 months and monitored (1) for the level of EB virus shedding in the throat by means of a sensitive cord-blood transformation assay; (2) for the level of virus-infected B cells in the blood via a new in vitro protocol where "spontaneous transformation" can be seen to titrate against input cell number; (3) for anti-EB viral antibody titres and (4) for the prevailing level of virus-specific memory T cells in the circulation. Six donors shed easily detectable levels of EB virus into throat washings on every occasion of testing, whilst 16 other donors shed lower levels of virus detectable in throat washings on a majority (10 donors) or on a minority (6 donors) of test occasions; only 2/24 donors gave no evidence of virus shedding at any time. There was a direct relationship between the EB virus shedder status of an individual (i.e., the level of virus replication in the pharynx) and the number of infected B cells present in the circulation. These results indicate that chronic, usually low-grade, replication of the virus at some permissive site in the oro- and/or naso-pharynx is very often a stable accompaniment of the asymptomatic EB virus carrier state, and may indeed be essential for the long-term maintenance of that state.
A phase 1, open-label study of LCAR-B38M, a chimeric antigen receptor T cell therapy directed against B cell maturation antigen, in patients with relapsed or refractory multiple myeloma (2018)

Chimeric antigen receptor (CAR) T cell therapy has demonstrated proven efficacy in some hematologic cancers. We evaluated the safety and efficacy of LCAR-B38M, a dual epitope-binding CAR T cell therapy directed against 2 distinct B cell maturation antigen epitopes, in patients with relapsed/refractory (R/R) multiple myeloma (MM). This ongoing phase 1, single-arm, open-label, multicenter study enrolled patients (18 to 80 years) with R/R MM. Lymphodepletion was performed using cyclophosphamide 300 mg/m2. LCAR-B38M CAR T cells (median CAR+ T cells, 0.5 × 106 cells/kg [range, 0.07 to 2.1 × 106]) were infused in 3 separate infusions. The primary objective is to evaluate the safety of LCAR-B38M CAR T cells; the secondary objective is to evaluate the antimyeloma response of the treatment based on the general guidelines of the International Myeloma Working Group. At data cutoff, 57 patients had received LCAR-B38M CAR T cells. All patients experienced ≥ 1 adverse events (AEs). Grade ≥ 3 AEs were reported in 37/57 patients (65%); most common were leukopenia (17/57; 30%), thrombocytopenia (13/57; 23%), and aspartate aminotransferase increased (12/57; 21%). Cytokine release syndrome occurred in 51/57 patients (90%); 4/57 (7%) had grade ≥ 3 cases. One patient reported neurotoxicity of grade 1 aphasia, agitation, and seizure-like activity. The overall response rate was 88% (95% confidence interval [CI], 76 to 95); 39/57 patients (68%) achieved a complete response, 3/57 (5%) achieved a very good partial response, and 8/57 (14%) achieved a partial response. Minimal residual disease was negative for 36/57 (63%) patients. The median time to response was 1 month (range, 0.4 to 3.5). At a median follow-up of 8 months, median progression-free survival was 15 months (95% CI, 11 to not estimable). Median overall survival for all patients was not reached. LCAR-B38M CAR T cell therapy displayed a manageable safety profile and demonstrated deep and durable responses in patients with R/R MM. ClinicalTrials.gov , NCT03090659 ; Registered on March 27, 2017, retrospectively registered
Electronic and Geometric Stabilities of Clusters with Transition Metal Encapsulated by Silicon (2006)

Silicon clusters mixed with a transition metal atom, MSin, were generated by a double-laser vaporization method, and the electronic and geometric stabilities for the resulting clusters with transition metal encapsulated by silicon were examined experimentally. By means of a systematic doping with transition metal atoms of groups 3, 4, and 5 (M = Sc, Y, Lu, Ti, Zr, Hf, V, Nb, and Ta), followed by changes of charge states, we explored the use of an electronic closing of a silicon caged cluster and variations in its cavity size to facilitate metal-atom encapsulation. Results obtained by mass spectrometry, anion photoelectron spectroscopy, and adsorption reactivity toward H2O show that the neutral cluster doped with a group 4 atom features an electronic and a geometric closing at n = 16. The MSi(16) cluster with a group 4 atom undergoes an electronic change in (i) the number of valence electrons when the metal atom is substituted by the neighboring metals with a group 3 or 5 atom and in (ii) atomic radii with the substitution of the same group elements of Zr and Hf. The reactivity of a halogen atom with the MSi(16) clusters reveals that VSi(16)F forms a superatom complex with ionic bonding.
Geoscience visualization with GPU programming (2005)

In recent years, off-the-shelf graphics cards have provided the ability to program the graphics processing unit (GPU) as an alternative to using fixed function pipelines. We believe that this capability can enable a new paradigm in geoscience data visualization. In the past, the geoscience data preparation, interpretation, and simulation were all done by the central processing unit (CPU), and then the generated graphics primitives were fed into a GPU for visualization. This approach was dictated by the constraints imposed by the general-purpose graphics application programming interfaces (APIs). With GPU programming, this front-end processing can be done in the GPU and visualized immediately. After passing the geometry data into the GPU, parameters can be used to control these processes inside the GPU. The different algorithms associated with these processes can be applied at run time by loading a new shading program. To prove this concept, we designed and implemented Java-based shader classes, which operate on top of Cg, a high-level language for graphics programming. These shader classes load Cg shaders to provide a new method for visualizing and interacting with geoscience data. The results from this approach show better visual quality for seismic data display and dramatically improved performance for large 3D seismic data sets. For editing geological surfaces, tests demonstrate performance levels 10 times faster than the typical approach. This paper describes the use of these shaders and presents the results of shader application to geoscience data visualization.
Parental Style and Consumer Socialization of Children (1988)

Journal Article Parental Style and Consumer Socialization of Children Get access Les Carlson, Les Carlson Search for other works by this author on: Oxford Academic PubMed Google Scholar Sanford Grossbart Sanford Grossbart Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Consumer Research, Volume 15, Issue 1, June 1988, Pages 77–94, https://doi.org/10.1086/209147 Published: 01 June 1988 Article history Received: 01 January 1987 Revision received: 01 November 1987 Published: 01 June 1988