gebhart/patrepeval huggingface dataset:
Keratinocytes express dipeptidyl-peptidase IV (CD26) in benign and malignant skin diseases (1996)

CD26 expression on keratinocytes, in both normal and pathological skin, was investigated using immunohistochemical techniques. A sporadic focal CD26 positivity was found in normal skin, whereas increased expression of CD26 was observed both in cutaneous T-cell lymphomas and in inflammatory skin diseases, e.g. psoriasis, lichen planus and spongiotic dermatitis, in the basal and spinous layers. CD26 keratinocyte staining was not specific for a single disease, but seems to be associated with the presence of a reactive or neoplastic infiltrate in the epidermis. We propose that the CD26 molecule may function as a keratinocyte activation antigen.
Preliminary Individualized Chemotherapy for Malignant Astrocytomas Based on O6-Methylguanine-Deoxyribonucleic Acid Methyltransferase Methylation Analysis (2006)

O(6)-methylguanine-deoxyribonucleic acid methyltransferase gene (MGMT) methylation is apparently correlated with responsiveness to nitrosourea chemotherapy, suggesting this alkylating agent should be effective against MGMT-methylated tumors. MGMT appears not to be linked to platinum resistance, so platinum chemotherapy should be used for MGMT-unmethylated tumors. This study was a preliminary trial of individualized chemotherapy based on MGMT methylation status in a total of 20 patients with newly diagnosed malignant astrocytomas (9 anaplastic astrocytomas and 11 glioblastomas multiforme). The procarbazine, 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-2(2-chloroethyl)-3-nitrosourea, and vincristine (PAV) regimen was administered to seven patients with MGMT-methylated tumors, and the carboplatin and etoposide (CE) regimen was administered to 13 patients with MGMT-unmethylated tumors. Objective response to the PAV therapy was noted in all three patients with measurable residual tumor (2 complete responses and 1 partial response). Five of the seven patients continued to be disease-free after initiation of the PAV therapy. Objective response to the CE therapy was seen in only one of seven patients with measurable residual tumor (1 partial response). Three of the 13 patients were free from progression, whereas the remaining 10 patients showed early progression. The PAV regimen is effective against MGMT-methylated malignant astrocytomas, but the CE regimen is not useful at the given dose and schedule in MGMT-unmethylated tumors.
Analog peak detector and derandomizer for high rate spectroscopy (2005)

A compact and accurate readout system has been developed for high-rate spectroscopy with multi-element detectors. The fully self-triggered system multiplexes the signals from 32 detectors into a novel peak detector, which also serves as a derandomizer. The captured pulse heights are stored as analog samples before being presented to the ADC along with the corresponding channel addresses. The peak detector incorporates a new two-phase configuration that cancels offsets and other errors found in conventional designs. Offset cancellation gives the peak detector rail-to-rail sensing and driving capability, and permits two or more peak detectors to be operated in parallel to serve as a data-driven analog memory. First experimental results on the new peak detector and derandomizer (PDD) circuit, fabricated in 0.35 /spl mu/m CMOS technology, include a 0.2% absolute accuracy for pulses with 500 ns peaking time, 2.7 V linear input range, 3.5 mW power dissipation, 250 mV/s droop rate, and negligible dead time. We have tested the system with 32 CZT detectors and a /sup 241/Am source. The spectra collected from the 32-channel system show that the noise performance of the preamp/shaper is not degraded by the multiplexing, peak detecting, and derandomizing operations.
The effects of vibration upon blood-viscosity and red-cell mobility: A study in vivo and in vitro (1982)

It has long been established that vibration can produce vasospastic disease with associated hyperviscosity. More recently it has been shown that short-term exposure to vibration may lead to increased blood-flow; the associated blood rheology of this
Aeration without air: Oxygen supply by hydrogen peroxide (1977)

Abstract Oxygen has been supplied to suspensions of microorganisms kept under nitrogen by the addition of hydrogen peroxide. If catalase was present in the suspension and the flow was adjusted to the rate of oxygen consumption, the cells grew at rates identical to the controls incubated under air. The applicability of oxygen supply by hydrogen peroxide and its limits are discussed.
An overview of variable rate speech coding for cellular networks (2003)

Variable rate speech coding is a critical system component for achieving very high capacity in future generation multiple access systems for cellular networks. A significant capacity gain comes from exploitation of the large fraction of the time during which a speaker is idle in a two-way conversation. Additional capacity gain can also be achieved by exploiting the time-varying entropy of active speech. While CDMA and packet-based multiple access systems, e.g. PRMA, are naturally suited for variable rate coding. TDMA can also be designed to benefit from voice activity patterns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hypolipidemic Activities of Dietary<i>Pleurotus ostreatus</i>in Hypercholesterolemic Rats (2011)

This work was conducted to investigate dietary supplementation of oyster mushroom fruiting bodies on biochemical and histological changes in hyper and normocholesterolemic rats. Six-week old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Feeding a diet containing a 5% powder of Pleurotus ostreatus fruiting bodies to hypercholesterolemic rats reduced plasma total cholesterol, triglyceride, low-density lipoprotein (LDL), total lipid, phospholipids, and LDL/high-density lipoprotein ratio by 30.18, 52.75, 59.62, 34.15, 23.89, and 50%, respectively. Feeding oyster mushrooms also significantly reduced body weight in hypercholesterolemic rats. However, it had no adverse effects on plasma albumin, total bilirubin, direct bilirubin, creatinin, blood urea nitrogen, uric acid, glucose, total protein, calcium, sodium, potassium, chloride, inorganic phosphate, magnesium, or enzyme profiles. Feeding mushroom increased total lipid and cholesterol excretion in feces. The plasma lipoprotein fraction, separated by agarose gel electrophoresis, indicated that P. ostreatus significantly reduced plasma β and pre-β-lipoprotein but increased α-lipoprotein. A histological study of hepatic cells by conventional hematoxylin-eosin and oil red O staining revealed normal findings for mushroom-fed hypercholesterolemic rats. These results suggest that a 5% P. ostreatus diet supplement provided health benefits by acting on the atherogenic lipid profile in hypercholesterolemic rats.
Effect of different growth conditions on the discrimination of three bacteria by pyrolysis gas-liquid chromatography (1980)

High-resolution pyrolysis gas-liquid chromatography was applied to three bacteria (Escherichia coli NCTC 9001, Pseudomonas putida (NCIB 9494, and Staphylococcus aureus NCTC 8532) grown under a variety of conditions. Changing the culture medium drastically altered the quantitative aspects of the pyrograms of all three organisms, but the effects of culture time and incubation temperature were less severe. Mathematical analysis of the relative peak heights showed that four peaks could be used to discriminate the three bacteria however they were cultured.
Viral vectors for targeting the canine retina: a review (2012)

Clinical trials are currently underway using gene therapy to treat retinal disease such as Leber congenital amaurosis (LCA). Viral vectors that have been utilized to target retinal cells include adenoviruses, lentiviruses, and recombinant adeno-associated viruses (rAAV). Of the three classes, rAAV vectors show the greatest promise for retinal gene therapy. Recent developments in virus technology such as the development of hybrid and capsid mutant rAAV vectors mean that specific retinal cells can be targeted and faster stronger transgene expression is now possible compared to that achieved with the first generation of vectors. Gene therapy trials in dogs have been very important in the development of therapy for RPE65 LCA which is currently in phase I/II clinical trials in humans. Recent successes in using gene therapy to treat canine achromatopsia, X-linked progressive retinal atrophy (PRA) and the more severe rapid degenerations such as rod-cone dysplasia type 3 may lead also to the translation to human clinical trials. Dogs have played and continue to play an important role as animal models for proof-of-concept studies of retinal gene therapy. As modifications and improvements in gene therapy protocols are made from experience gathered from human clinical trials perhaps gene therapy for the treatment of canine clinical patients will become available to veterinary ophthalmologists.
A concept for miniaturized 3‐D cell culture using an extracellular matrix gel (2005)

This paper presents a novel method to embed, anchor, and cultivate cells in a controlled 3-D flow-through microenvironment. This is realized using an etched silicon pillar flow chamber filled with extracellular matrix (ECM) gel mixed with cells. At 4 degrees C, while in liquid form, ECM gel is mixed with cells and injected into the chamber. Raising the temperature to 37 degrees C results in a gel, with cells embedded. The silicon pillars both stabilize and increase the surface to volume ratio of the gel. During polymerization the gel shrinks, thus creating channels, which enables perfusion through the chip. The pillars increase the mechanical stability of the gel permitting high surface flow rates without surface modifications. Within the structure cells were still viable and proliferating after 6 days of cultivation. Our method thus makes it possible to perform medium- to long-term cultivation of cells in a controlled 3-D environment. This concept opens possibilities to perform studies of cells in a more physiological environment compared to traditional 2-D cultures on flat substrates.
Bernadette Lizet, La Bête noire. Ministère de la Culture et de la Communication, collection Ethnologie de la France, Paris, Éditions de la Maison des Sciences de l'Homme, 1989 (1990)

Petit Françoise-Eugénie. Bernadette Lizet, La Bête noire. Ministère de la Culture et de la Communication, collection Ethnologie de la France, Paris, Éditions de la Maison des Sciences de l'Homme, 1989. In: Gradhiva : revue d'histoire et d'archives de l'anthropologie, n°8, 1990. pp. 113-114.
Measuring Invariances in Deep Networks (2009)

For many pattern recognition tasks, the ideal input feature would be invariant to multiple confounding properties (such as illumination and viewing angle, in com-puter vision applications). Recently, deep architectures trained in an unsupervised manner have been proposed as an automatic method for extracting useful features. However, it is difficult to evaluate the learned features by any means other than using them in a classifier. In this paper, we propose a number of empirical tests that directly measure the degree to which these learned features are invariant to different input transformations. We find that stacked autoencoders learn modestly increasingly invariant features with depth when trained on natural images. We find that convolutional deep belief networks learn substantially more invariant features in each layer. These results further justify the use of “deep ” vs. “shallower ” repre-sentations, but suggest that mechanisms beyond merely stacking one autoencoder on top of another may be important for achieving invariance. Our evaluation met-rics can also be used to evaluate future work in deep learning, and thus help the development of future algorithms. 1
Wi-Green: Optimization of the Power Consumption of Wi-Fi Networks Sensitive to Traffic Patterns (2017)

Enterprise Wi-Fi networks have been increasingly considering energy efficiency. In this paper, we present the Wi-Green project wherein we are investigating new techniques and innovative solutions that will allow the minimization of the energy consumption in Wi-Fi networks. In Wi-Green we will consider an enterprise network, in which there is equipment from different vendors, with different ages and different consumption profiles.
INTERNAL COOLING OF METAL‐CUTTING TOOLS (1972)

The copyright of this paper belongs to the Society of Manufacturing Engineers of Dearborn, Michigan, by whose kind permission it is reproduced here. It was written for their Creative Manufacturing Engineering Programmes. The internal method of cooling metal‐cutting tools is explained and it is shown that this method can provide 50% reduction in wear on the flank surfaces of cutting tools. A sintered copper wick shim also effects improvement.
A New Fluorescence Resonance Energy Transfer Approach Demonstrates That the Histone Variant H2AZ Stabilizes the Histone Octamer within the Nucleosome (2004)

Nucleosomes are highly dynamic macromolecular complexes that are assembled and disassembled in a modular fashion. One important way in which this dynamic process can be modulated is by the replacement of major histones with their variants, thereby affecting nucleosome structure and function. Here we use fluorescence resonance energy transfer between fluorophores attached to various defined locations within the nucleosome to dissect and compare the structural transitions of a H2A.Z containing and a canonical nucleosome in response to increasing ionic strength. We show that the peripheral regions of the DNA dissociate from the surface of the histone octamer at relatively low ionic strength, under conditions where the dimer-tetramer interaction remains unaffected. At around 550 mm NaCl, the (H2A-H2B) dimer dissociates from the (H3-H4)(2) tetramer-DNA complex. Significantly, this latter transition is stabilized in nucleosomes that have been reconstituted with the essential histone variant H2A.Z. Our studies firmly establish fluorescence resonance energy transfer as a valid method to study nucleosome stability, and shed new light on the biological function of H2A.Z.
Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling (2016)

Inflammation in arterial walls leads to coronary artery disease (CAD). Because specialized proresolving lipid mediators (SPMs; lipoxins, resolvins, and protectins) stimulate resolution of inflammation in animal models, we tested whether n-3 fatty acids impact SPM profiles in patients with CAD and promote clot remodeling. Six patients with stable CAD were randomly assigned to either treatment with daily 3.36 g Lovaza for 1 yr or without. Targeted lipid mediator-metabololipidomics showed that both groups had absence of resolvin D1 (RvD1), RvD2, RvD3, RvD5 and resolvin E1-all of which are present in healthy patients. Those not taking Lovaza had an absence of aspirin-triggered resolvin D3 (AT-RvD3) and aspirin-triggered lipoxin B4 (AT-LXB4). Lovaza treatment restored AT-RvD3 and AT-LXB4 and gave levels of RvD6 and aspirin-triggered protectin D1 (AT-PD1) twice as high (resolvin E2 ∼5 fold) as well as lower prostaglandins. Principal component analysis indicated positive relationships for patients with CAD who were receiving Lovaza with increased AT-RvD3, RvD6, AT-PD1, and AT-LXB4 SPMs identified in Lovaza-treated patients with CAD enhanced ∼50% at 1 nM macrophage uptake of blood clots. These results indicate that patients with CAD have lower levels and/or absence of specific SPMs that were restored with Lovaza; these SPMs promote macrophage phagocytosis of blood clots. Together, they suggest that low vascular SPMs may enable progression of chronic vascular inflammation predisposing to coronary atherosclerosis and to thrombosis.-Elajami, T. K., Colas, R. A., Dalli, J., Chiang, N., Serhan, C. N., Welty, F. K. Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling.
Rapid thermal anneal of sprayed Y1Ba2Cu3O7−<i>x</i> slurry (1988)

Thick (∼ 20 μm) superconducting films of Y1 Ba2 Cu3 O7−x have been produced on 3 in. wafers of silicon, SiO2 -coated silicon, and sapphire. The process involves spraying of a slurry of finely ground powder of Y1 Ba2 Cu3 O7−x and methyl alcohol, followed by rapid thermal anneal for sintering. The Tc for Si, SiO2 , and sapphire are 70, 81, and 62 K, respectively. Post-sinter anneal in oxygen at 400 °C further increases Tc . The adhesion of the films sintered above 980 °C is excellent.
Organometalloidal derivatives of the transition metals. 24. Chemical and structural investigations of (ferrocenylacyl) silanes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganometalloidal derivatives of the transition metals. 24. Chemical and structural investigations of (ferrocenylacyl) silanesHemant K. Sharma, Steven P. Vincenti, Robin Vicari, Francisco Cervantes, and Keith H. PannellCite this: Organometallics 1990, 9, 7, 2109–2116Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/om00157a022https://doi.org/10.1021/om00157a022research-articleACS PublicationsRequest reuse permissionsArticle Views117Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
DNA methylation patterns in bladder cancer and washing cell sediments: a perspective for tumor recurrence detection (2008)

Indistinct DNA hypermethylation of CDH1 and SFN genes between tumoral and normal urinary bladder samples suggests that these epigenetic features are not suitable biomarkers for urinary bladder cancer. However, RARB and RASSF1A gene methylation appears to be an initial event in urinary bladder carcinogenesis and should be considered as defining a panel of differentially methylated genes in this neoplasia in order to maximize the diagnostic coverage of epigenetic markers, especially in studies aiming at early recurrence detection.
The Influence of Cobalt Content on the Volume Fraction of Discontinuous Precipitation Cells in Cu-2 wt%Be-Co Alloys (1980)

The influence of Co content on the volume fraction of discontinuous precipitation cells has been investigated in Cu-2 wt%Be-Co alloys containing Co from 0.05 to 1.0 wt% by means of metallographic observations. The variation in the volume fraction of discontinuous precipitation cells, cell radius and interlamellar spacing with Co content in the specimens of a given ageing condition, and also the variation in mean grain diameter with Co content have been determined by quantitative metallographic measurements. The results obtained are as follows:(1) With increasing Co content, the volume fraction of discontinuous precipitation cells first decreases but passes through a minimum at Co content of about 0.2 wt% and then increases.(2) With increasing Co content, cell radius and interlamellar spacing first decreases and increases, respectively, but they remain almost constant at higher Co content, while mean grain diameter decreases continuously.(3) At constant Co content, cell radius does not depend on mean grain diameter but the volume fraction of discontinuous precipitation cells increases with decreasing mean grain diameter.(4) Then it is considered that the change in the volume fraction of the discontinuous precipitation cells at lower and higher Co content will be attributed to decrease in cell radius and mean grain diameter, respectively.(5) The influence of Co content on cell radius and interlamellar spacing will be correlated to the equilibrium phase diagram of Cu-Be-Co ternary alloy in view of the driving force for cell growth.
Nitrite and nitrate: cardiovascular risk–benefit and metabolic effect (2010)

The cardiovascular benefits of nitrite and nitrate are beginning to be translated in humans by the increasing number of clinical trials using nitrite and nitrate. The collective body of evidence suggests that foods enriched in nitrite and nitrate provide significant health benefits with very little risk.
Detection of Non-Conjugative Interactions in Rigid Cyclic Molecules by Using Carbon-13 N.M.R. Shift Values (1987)

In previous work, interaction between formally unconjugated unsaturated groups was detected by comparing the 13C n.m.r. shift values of the sp2 atoms of difunctional compounds with those of the corresponding monofunctional compounds. This procedure has now been used to investigate possible interactive effects in a range of rigid alicyclic systems where steric and conformational factors cannot be involved, namely, the 2,6-disubstituted adamantane (6), 4,8-disubstituted 2-thiaadamantane (7), 2,6-disubstituted noradamantane (8), and 2,5-disubstituted norbornane (9) systems. In each case interaction was detected between the unsaturated groups of the non-conjugated dimethylene, methylene ketone, and diketone derivatives of these ring systems. The nature of this effect is under further investigation.
Newcastle disease virus: Macromolecules and opportunities (2001)

Over the past two decades, enormous advances have occurred in the structural and biological characterization of Newcastle disease virus (NDV). As a result, not only the complete sequence of the viral genome has been fully determined, but also a clearer understanding of the viral proteins and their respective roles in the life cycle has been achieved. This article reviews the progress in the molecular biology of NDV with emphasis on the new technologies. It also identifies the fundamental problems that need to be addressed and attempts to predict some research opportunities in NDV that can be realized in the near future for the diagnosis, prevention and treatment of disease(s).
Effects of isotopic disorder on the phonon spectrum of diamond (1991)

We examine the phonon spectrum of isotopically disordered diamond using the coherent-potential approximation (CPA). Predictions for the zone-center optic mode are compared to measurements of the first-order Raman spectrum of high-quality, single-crystal, synthetic diamonds with isotopic compositions ranging from nearly pure $^{12}\mathrm{C}$ to nearly pure $^{13}\mathrm{C}$. The CPA accounts very well for the observed nonlinear composition dependence (``bowing'') of the Raman mode and for its asymmetric variation in width. The maximum disorder-induced broadening predicted by the CPA for naturally abundant diamond (1.1% $^{13}\mathrm{C}$) is less than 1 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$, nearly 2 orders of magnitude smaller than that assumed in a previous study of the possible effects of isotopic disorder on the thermal conductivity of diamond.