gebhart/patrepeval huggingface dataset:
A testability-driven optimizer and wrapper generator for embedded memories (2004)

Memory cores (especially SRAM cores) used on a system chip usually come from a memory compiler. Commercial memory compilers have their limitation-a large memory may need to be implemented with multiple small memories, if generated by memory compilers. In this paper we introduce a testability-driven memory optimizer and wrapper generator that generates BISTed embedded memories by using a commercial memory compiler. We describe one of its key components called MORE (for Memory Optimization and REconfiguration). The approach is cost effective for designing embedded memories. By configuring small memory cores into the large one specified by the user and providing the BIST circuits, MORE allows the user to combine the commercial memory compiler and our memory BIST compiler into a cost-effective testability-driven memory generator. The resulting memory has a shorter test time, since the small memory cores can be tested in parallel, so far as the power and geometry constraints are considered. As an example, the test time of a typical 256 K/spl times/32 memory generated by MORE is reduced by about 75%.
Covalent Immunoglobulin Labeling through a Photoactivable Synthetic Z Domain (2011)

Traditionally, labeling of antibodies has been performed by covalent conjugation to amine or carboxyl groups. These methods are efficient but suffer from nonspecificity, since all free and available amine/carboxyl groups have the possibility to react. This drawback may lead to uncontrolled levels and locations of the labeling. Hence, the labeled molecules might behave differently and, possibly, the binding site of the antibody will also be affected. In this project, we have developed a highly stringent method for labeling of antibodies by utilizing an immunoglobulin-binding domain from protein A, the Z domain. Domain Z has been synthesized with an amino acid analogue, benzoylphenylalanine, capable of forming covalent attachment to other amino acids upon UV-exposure. This feature has been used for directed labeling of immunoglobulins and subsequent use of these in different assays.
<i>N</i>‐Chlorcarbonyl‐isocyanat – Synthese und Reaktionen (1977)

Abstract ClCONCO ( N ‐Chlorcarbonyl‐isocyanat) wird durch partielle Verseifung des Additionsprodukts aus Phosgen und Chlorcyan mit 90% Ausbeute hergestellt. Aus dem sehr reaktiven N ‐Chlorcarbonyl‐isocyanat, dem das Gerüst der Iminodicarbonsäure zugrunde liegt, lassen sich viele Derivate dieser Reihe gewinnen. Sowohl die Säurechlorid‐ als auch die Isocyanatgruppe sind im Ergebnis selektiven Umsetzungen zugänglich. Dies eröffnet unter anderem einen präparativ einfachen Weg zur Herstellung von Isocyanaten aus Alkoholen, Phenolen, Thiolen und Thiophenolen. Die Kombination der beiden funktionellen Gruppen und ihre eigenartige Symmetrie, die z. B. im HCl‐Addukt deutlich wird, befähigen N ‐Chlorcarbonyl‐isocyanat außerdem, unter milden Bedingungen Cyclisierungsreaktionen einzugehen.
Metabolism of 16.alpha.-hydroxylated C19 steroids in late pregnancy (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetabolism of 16.alpha.-hydroxylated C19 steroids in late pregnancyEdward. YoungLai and Samuel. SolomonCite this: Biochemistry 1968, 7, 5, 1881–1888Publication Date (Print):May 1, 1968Publication History Published online1 May 2002Published inissue 1 May 1968https://pubs.acs.org/doi/10.1021/bi00845a036https://doi.org/10.1021/bi00845a036research-articleACS PublicationsRequest reuse permissionsArticle Views31Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analysis of charge pumps using charge balance (2002)

A simple, generalized method for steady-state analysis of charge pumps or switched-capacitor power supplies, which is intuitive yet accurate, is presented. Second order effects that were previously not considered are included. The analysis is compared with simulations and shown to be accurate. The significance of the equations for analyzing charge pumps is also discussed.
Activation of Intercellular Adhesion Molecule 1 Expression by<i>Helicobacter pylori</i>Is Regulated by NF-κB in Gastric Epithelial Cancer Cells (2000)

Interactions between leukocytes and epithelial cells may play a key role in Helicobacter pylori-associated gastric mucosal inflammation. This process is mediated by various cell adhesion molecules. The present study examined the molecular mechanisms leading to H. pylori-induced epithelial cell intercellular adhesion molecule-1 (ICAM-1; also called CD54) expression. Coculture of epithelial cells with cytotoxin-associated gene pathogenicity island-positive (cag PAI(+)) H. pylori strains, but not with a cag PAI(-) strain or H. pylori culture supernatants, resulted in upregulation of steady-state mRNA levels and cell surface expression of ICAM-1. Coculture with H. pylori induced an increase in luciferase activity in cells which were transfected with a luciferase reporter gene linked to the 5'-flanking region of the ICAM-1 gene. H. pylori activated the ICAM-1 promoter via the NF-kappaB binding site. An inducible nuclear protein complex bound to the ICAM-1 NF-kappaB site and was identified as the NF-kappaB p50-p65 heterodimer. H. pylori induced the degradation of IkappaB-alpha, a major cytoplasmic inhibitor of NF-kappaB, and stimulated the expression of IkappaB-alpha mRNA. Pretreatment of epithelial cells with pyrrolidine dithiocarbamate, which blocks NF-kappaB activation, inhibited H. pylori-induced ICAM-1 expression. THP-1 macrophagic cells, peripheral blood mononuclear cells, and purified neutrophils adhered to H. pylori-infected epithelial cells to a greater extent than to uninfected cells. These results show that H. pylori directly induces expression of ICAM-1 on gastric epithelial cells in an NF-kappaB-dependent manner that may support leukocyte attachment during inflammation.
Coliphage BA14: a New Relative of Phage T7 (1982)

Coliphage BA14 was isolated from sewage and shown to be related to phages T7 and T3. It is similar to T3 in that it directs the synthesis of an S-adenosyl-methionine-cleaving enzyme (SAMase) early upon infection. However, it differs from all other known T7-related coliphages by the inability of its RNA polymerase (gene 1 product) to transcribe T7 DNA or T3 DNA. BA14, T7 and T3 also show marked differences in autoradiographic patterns of their gel-electrophoretically separated 35S-labelled intracellular phage proteins, restriction endonuclease HpaI cleavage patterns of their DNAs, and serological specificities of their infectious particles. Other distinctive features became apparent upon simultaneous mixed infection with BA14 and T7 or T3: inability of BA14 to produce genetic recombinants with either T7 or T3; lack of functional complementation between amber mutants of BA14 and T7 or T3; mutual exclusion and depression of the burst size of the mixedly infected cells.
A simple and fast DNA compressor (2004)

Abstract In this paper we consider the problem of DNA compression. It is well known that one of the main features of DNA sequences is that they contain substrings which are duplicated except for a few random mutations. For this reason most DNA compressors work by searching and encoding approximate repeats. We depart from this strategy by searching and encoding only exact repeats. However, we use an encoding designed to take advantage of the possible presence of approximate repeats. Our approach leads to an algorithm which is an order of magnitude faster than any other algorithm and achieves a compression ratio very close to the best DNA compressors. Another important feature of our algorithm is its small space occupancy which makes it possible to compress sequences hundreds of megabytes long, well beyond the range of any previous DNA compressor. Copyright © 2004 John Wiley & Sons, Ltd.
Treatment of microscopic pulmonary metastases with recombinant autologous tumor vaccine expressing interleukin 6 and Escherichia coli cytosine deaminase suicide genes. (1996)

Poorly immunogenic tumor cells genetically transduced to simultaneously express the cytokine interleukin 6 (IL-6) and the bacterial metabolic suicide gene cytosine deaminase (205-IL6-CD) become highly immunogenic. They are rejected by normal mice without 5-fluorocytosine prodrug treatment. Mice with preexisting wild-type pulmonary micrometastases exhibit prolonged survival and an increased rate of cure when treated with live 205-IL6-CD cells as a therapeutic vaccine. Treatment with these autologous tumor cells producing both the cytokine and the bacterial protein was more effective than treatment with exogenous IL-6 and/or irradiated wild-type tumor cells. Irradiation of the 205-IL6-CD cells significantly reduced their therapeutic efficacy. Therapeutic vaccination with 205-IL6-CD was more effective in animals with wild-type 205 tumor than in animals bearing an unrelated syngeneic tumor. Vaccine efficacy was significantly reduced in animals pretreated with high-dose cyclophosphamide. The results indicate that genetically engineered autologous tumor vaccines may be capable of inducing significant antitumor immunity in hosts of preexisting micrometastatic disease.
Glucan-immunostimulant, adjuvant, potential drug (2010)

β-glucans belong to a group of biologically active natural compounds called biological response modifiers. These substances represent highly conserved structural components of cell walls in fungi, yeast, grain and seaweed. Despite almost 160 years of intensive research, the exact mechanisms of their action remain unsolved. The significant role of glucans in cancer treatment, infection immunity, stress reduction and restoration of damaged bone marrow has already been established. The present review focuses on the various less known but potentially significant roles glucans might play in medicine. In summary, glucan might represent the most important natural immunomodulator.
Syntheses of [6,6]-Fused-Ring 1,2-Azaborines (2014)

BN-naphthalene (2) and BN-tetralin (7) have been prepared by a short synthesis from allyltributylstannane (3). The reaction of 3 with BCl3 followed by diallylamine and Et3N afforded (diallylamino)diallylborane (5), which gave 1,4,5,8-tetrahydro[1,2]azaborino[1,2-a][1,2]azaborine (6), on treatment with Grubbs (I) catalyst. The reaction of 6 with Pd gave 2 and 7. The reaction of 7 with Cr(CO)6 gave the corresponding Cr(CO)3 adduct 8, for which a crystal structure has been obtained. The isomerization of 6 to 7 has been examined using DFT calculations.
Addition reaction of benzylbenzylidenenamine to lithium enolates of 1,3-dioxolan-4-one: synthesis of 2-phenylisoserines (2011)

The synthesis of two new 2-phenylisoserines, each bearing a quaternary stereocenter is described. These compounds, which are analogs of the amino acid side chain found in taxol and taxotere, were obtained by addition of the lithium enolates of (2S,5S)-2-isopropyl-5-phenyl-1,3dioxolan-4-one and (2S,5S)-2-tert-butyl-2-methyl-5-phenyl-1,3-dioxolan-4-one to benzylbenzylideneamine in the presence of BF3 . O(Et)2. The diastereomeric mixtures were separated in each case and the absolute configurations thereof were determined by X-ray analysis.
Regulation of Carbon and Electron Flow in <i>Clostridium butyricum</i> VPI 3266 Grown on Glucose-Glycerol Mixtures (2001)

The metabolism of Clostridium butyricum was manipulated at pH 6.5 and in phosphate-limited chemostat culture by changing the overall degree of reduction of the substrate using mixtures of glucose and glycerol. Cultures grown on glucose alone produced only acids (acetate, butyrate, and lactate) and a high level of hydrogen. In contrast, when glycerol was metabolized, 1,3-propanediol became the major product, the specific rate of acid formation decreased, and a low level of hydrogen was observed. Glycerol consumption was associated with the induction of (i) a glycerol dehydrogenase and a dihydroxyacetone kinase feeding glycerol into the central metabolism and (ii) an oxygen-sensitive glycerol dehydratase and an NAD-dependent 1,3-propanediol dehydrogenase involved in propanediol formation. The redirection of the electron flow from hydrogen to NADH formation was associated with a sharp decrease in the in vitro hydrogenase activity and the acetyl coenzyme A (CoA)/free CoA ratio that allows the NADH-ferredoxin oxidoreductase bidirectional enzyme to operate so as to reduce NAD in this culture. The decrease in acetate and butyrate formation was not explained by changes in the concentration of phosphotransacylases and acetate and butyrate kinases but by changes in in vivo substrate concentrations, as reflected by the sharp decrease in the acetyl-CoA/free CoA and butyryl-CoA/free CoA ratios and the sharp increase in the ATP/ADP ratio in the culture grown with glucose and glycerol compared with that in the culture grown with glucose alone. As previously reported for Clostridium acetobutylicum (L. Girbal, I. Vasconcelos, and P. Soucaille, J. Bacteriol. 176:6146-6147, 1994), the transmembrane pH of C. butyricum is inverted (more acidic inside) when the in vivo activity of hydrogenase is decreased (cultures grown on glucose-glycerol mixture). For both cultures, the stoichiometry of the H(+) ATPase was shown to remain constant and equal to 3 protons exported per molecule of ATP consumed.
The effect of centrally administered TRH on blood pressure, heart rate and ventilation in rat (1979)

Different doses (3, 16, 80, 400 and 2 000 ng per rat) of TRH or alternatively saline were infused into the lateral ventricle of urethane-anaesthetized rats and blood pressure, heart rate, respiration rate and tidal volume were recorded. A dose of 3 ng TRH caused a significant elevation of blood pressure and heart rate, whereas 16 ng was needed for respiration rate to be elevated. There was no change in respiratory minute volume during the experiment. We conclude that TRH has profound physiological effects and that TRH, given centrally, is a potent hypertensive, chronotropic and tachypnoeic agent.
Formylation of Amines with Phenyl Formate (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormylation of Amines with Phenyl FormateHarry YaleCite this: J. Org. Chem. 1971, 36, 21, 3238–3240Publication Date (Print):October 1, 1971Publication History Published online30 July 2003Published inissue 1 October 1971https://pubs.acs.org/doi/10.1021/jo00820a603https://doi.org/10.1021/jo00820a603research-articleACS PublicationsRequest reuse permissionsArticle Views854Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DocCreator: A New Software for Creating Synthetic Ground-Truthed Document Images (2017)

Most digital libraries that provide user-friendly interfaces, enabling quick and intuitive access to their resources, are based on Document Image Analysis and Recognition (DIAR) methods. Such DIAR methods need ground-truthed document images to be evaluated/compared and, in some cases, trained. Especially with the advent of deep learning-based approaches, the required size of annotated document datasets seems to be ever-growing. Manually annotating real documents has many drawbacks, which often leads to small reliably annotated datasets. In order to circumvent those drawbacks and enable the generation of massive ground-truthed data with high variability, we present DocCreator, a multi-platform and open-source software able to create many synthetic image documents with controlled ground truth. DocCreator has been used in various experiments, showing the interest of using such synthetic images to enrich the training stage of DIAR tools.
ANTIPROLIFERATIVE ACTIVITY IS PRESENT IN BLADDER BUT NOT RENAL PELVIC URINE FROM INTERSTITIAL CYSTITIS PATIENTS (1999)

The antiproliferative factor previously found in the urine of IC patients appears to be made and/or activated in the distal ureter or urinary bladder.
Optical frequency optimization of a high intensity laser power beaming system utilizing VMJ photovoltaic cells (2011)

An effective form of wireless power transmission (WPT) has been developed to enable extended mission durations, increased coverage and added capabilities for both space and terrestrial applications that may benefit from optically delivered electrical energy. The high intensity laser power beaming (HILPB) system enables long range optical `refueling' of electric platforms such as micro unmanned aerial vehicles (MUAV), airships, robotic exploration missions and spacecraft platforms. To further advance the HILPB technology, the focus of this investigation is to determine the optimal laser wavelength to be used with the HILPB receiver, which utilizes vertical multi-junction (VMJ) photovoltaic cells. Frequency optimization of the laser system is necessary in order to maximize the conversion efficiency at continuous high intensities, and thus increase the delivered power density of the HILPB system. Initial spectral characterizations of the device performed at the NASA Glenn Research Center (GRC) indicate the approximate range of peak optical-to-electrical conversion efficiencies, but these data sets represent transient conditions under lower levels of illumination. Extending these results to high levels of steady state illumination, with attention given to the compatibility of available commercial off-the-shelf semiconductor laser sources and atmospheric transmission constraints is the primary focus of this paper. Experimental hardware results utilizing high power continuous wave (CW) semiconductor lasers at four different operational frequencies near the indicated band gap of the photovoltaic VMJ cells are presented and discussed. In addition, the highest receiver power density achieved to date is demonstrated using a single photovoltaic VMJ cell, which provided an exceptionally high electrical output of 13.6 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at an optical-to-electrical conversion efficiency of 24 %. These results are very promising and scalable, as a potential 1.0 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> HILPB receiver of similar construction would be able to generate 136 kW of electrical power under similar conditions.
Waveguide-integrated single-crystalline GaP resonators on diamond (2014)

Large-scale entanglement of nitrogen-vacancy (NV) centers in diamond will require integration of NV centers with optical networks. Toward this goal, we present the fabrication of single-crystalline gallium phosphide (GaP) resonator-waveguide coupled structures on diamond. We demonstrate coupling between 1 μm diameter GaP disk resonators and waveguides with a loaded Q factor of 3,800, and evaluate their potential for efficient photon collection if integrated with single photon emitters. This work opens a path toward scalable NV entanglement in the hybrid GaP/diamond platform, with the potential to integrate on-chip photon collection, switching, and detection for applications in quantum information processing.
Vehicle tracking and motion prediction in complex urban scenarios (2010)

The recognition of potentially hazardous situations on road intersections is an indispensable skill of future driver assistance systems. In this context, this study focuses on the task of vehicle tracking in combination with a long-term motion prediction (1-2 s into the future) in a dynamic scenario. A motion-attributed stereo point cloud obtained using computationally efficient feature-based methods represents the scene, relying on images of a stereo camera system mounted on a vehicle. A two-stage mean-shift algorithm is used for detection and tracking of the traffic participants. A hierarchical setup depending on the history of the tracked object is applied for prediction. This includes prediction by optical flow, a standard kinematic prediction, and a particle filter based motion pattern method relying on learned object trajectories. The evaluation shows that the proposed system is able to track the road users in a stable manner and predict their positions at least one order of magnitude more accurately than a standard kinematic prediction method.
Myocyte Enhancer Factor 2C and Nkx2–5 Up-regulate Each Other's Expression and Initiate Cardiomyogenesis in P19 Cells (1998)

The Nkx2-5 homeodomain protein plays a key role in cardiomyogenesis. Ectopic expression in frog and zebrafish embryos results in an enlarged myocardium; however, expression of Nkx2-5 in fibroblasts was not able to trigger the development of beating cardiac muscle. In order to examine the ability of Nkx2-5 to modulate endogenous cardiac specific gene expression in cells undergoing early stages of differentiation, P19 cell lines overexpressing Nkx2-5 were differentiated in the absence of Me2SO. Nkx2-5 expression induced cardiomyogenesis in these cultures aggregated without Me2SO. During differentiation into cardiac muscle, Nkx2-5 expression resulted in the activation of myocyte enhancer factor 2C (MEF2C), but not MEF2A, -B, or -D. In order to compare the abilities of Nkx2-5 and MEF2C to induce cellular differentiation, P19 cells overexpressing MEF2C were aggregated in the absence of Me2SO. Similar to Nkx2-5, MEF2C expression initiated cardiomyogenesis, resulting in the up-regulation of Brachyury T, bone morphogenetic protein-4, Nkx2-5, GATA-4, cardiac alpha-actin, and myosin heavy chain expression. These findings indicate the presence of a positive regulatory network between Nkx2-5 and MEF2C and show that both factors can direct early stages of cell differentiation into a cardiomyogenic pathway.