gebhart/patrepeval huggingface dataset:
Transplantation of adipose-derived stem cells for peripheral nerve repair (2011)

Mesenchymal stem cells have become a very attractive source of cell implantation for neural tissue engineering. The ideal stem cells for transplantation should be easily obtained, and should rapidly proliferate in vitro and have low immunogenicity. The purpose of this study was to investigate the regenerative potential of adipose-derived stem cells (ADSC) on peripheral nerve repair. ADSCs were isolated from rat adipose tissue and cultured until adherent cells became morphologically homogeneous with a fibroblast-like shape, and transplanted with acellular nerve allografts (ANAs) into rat models with a 10 mm gap of transected sciatic nerve defect. After cell transplantation, we found that ADSC implantation improved functional recovery of exercise behavior and increased wet weight ratio of the anterior tibial muscle. In the electrophysiological testing, we found that the percentage of activated fibers was higher in the ADSC-implanted animals as evidenced by the increase of nerve conduction velocity and amplitude. Histological examination revealed that the number of nerve fibers, axonal diameter and myelin thickness were significantly higher in the ADSC-implanted animals compared to the control. In addition, we demonstrated that the progression of the regenerative process after ADSC implantation was accompanied by elevated expression of neurotrophic factors at both the early and later phase. Taken together, these results suggest that ADSCs can promote the repair of peripheral nerve injury, and the combination of ADSC and ANA transplantation is a new therapeutic method for long distant peripheral nerve defects. Our data also provide evidence indicating the strong association of neurotrophic factor production to the regenerative potential of implanted ADSCs.
Validation of Urdu Interaction with Disabled Persons scale (2003)

This study developed a valid and reliable Urdu language measure that can be used for assessing attitudes toward persons with physical disability in Pakistan. The Interaction with Disabled Persons scale (IDP), which measures attitudes of discomfort with interaction with disabled people, is a scale with established validity and reliability in English and other languages. An Urdu translation was back-translated to English and then reviewed by a committee to develop cultural validity. Data were collected from 591 Urdu-speaking Pakistani people. Factor analysis extracted four factors that accounted for 55% of the variance and reflected factors found in 12 previous studies. Cronbach's alpha described moderate internal consistency for the IDP.
Digitisation as a method of preservation (1998)

Digitisation as a method of preservation? (Hartmut Weber & Marianne Dorr)
TCR α-chain usage can determine antigen-selected TCR β-chain repertoire diversity (1996)

There is considerable variation in the TCR repertoire diversity selected by different peptide Ags. Certain responses show limited V region bias with minimal restrictions in the remainder of the sequence while others can be dominated by a single TCR clonotype repeatedly isolated from different individuals. CTL specific for a Kb-restricted determinant from the herpes simplex virus glycoprotein B (gB) preferentially express a dominant TCRBV10 beta-chain subset with extensive conservation located at the V-D junction. However, unlike some biased responses, no single beta-chain V-D-J combination appears to dominate these CTL. Different animals respond with a large array of unique or "private" beta-chain sequences with little J region preference. Here we examine the contribution of the TCR alpha-chain to the gB-specific CTL diversity. The TCR alpha-chains from different TCRBV10-positive gB-specific CTL clones were found to exhibit extensive sequence variation. However, when T cells were forced to use a single alpha-chain in TCR alpha-chain transgenic mice, gB-specific CTL showed limited variation in their beta-chain selection. These T cells retained the TCRBV10 bias but were now dominated by a single beta-chain sequence that could be repeatedly isolated from different transgenic animals. This "public" TCR consisted of the transgenic alpha-chain and a common TCRBV10D2J2S6 beta-chain. These results suggest that preferential use of one TCR subunit can restrict the level of diversity in the other chain due to interchain interactions involving J-derived sequences.
High-speed holocinematographic velocimeter for studying turbulent flow control physics (1985)

Use of a dual view, high speed, holographic movie technique is examined for studying turbulent flow control physics. This approach, which eliminates some of the limitations of previous holographic techniques, is termed a holocinematographic velocimeter (HCV). The data from this system can be used to check theoretical turbulence modeling and numerical simulations, visualize and measure coherent structures in 'non-simple' turbulent flows, and examine the mechanisms operative in various turbulent control/drag reduction concepts. This system shows promise for giving the most complete experimental characterization of turbulent flows yet available.
Offset and Tilt Loss in Optical Fiber Splices (1976)

Transverse offset and angular misalignment (tilt) are serious causes of loss in multimode fiber splices. Our computation of these losses in multimode graded-index fibers reveals that the loss depends strongly on the power distribution in the fiber. We find that offsets of 0.1 of the core radius (or tilts of 0.1 of the fiber numerical aperture) cause a loss of 0.1 dB in the case of steady-state conditions, and between 0.34 and 0.38 dB if the power distribution is assumed as uniform. We compare these results with measured offset loss values and conclude that the steady-state distribution better reflects transmission line conditions than the uniform distribution.
Adverse Drug Reactions (2014)

Abstract Along with their many benefits, prescription drugs have harmful side effects and constitute a leading cause of death and hospitalization in the United States and other affluent countries. More people benefit from prescription drugs than any other aspect of medicine. Yet these drugs have become a major cause of falls, accidents, hospitalizations, and death.
Molecular coevolution among cryptically simple expansion segments of eukaryotic 26S/28S rRNAs. (1988)

The set of "expansion segments" of any eukaryotic 26S/28S ribosomal RNA (rRNA) gene is responsible for the bulk of the difference in length between the prokaryotic 23S rRNA gene and the eukaryotic 26S/28S rRNA gene. The expansion segments are also responsible for interspecific fluctuations in length during eukaryotic evolution. They show a consistent bias in base composition in any species; for example, they are AT rich in Drosophila melanogaster and GC rich in vertebrate species. Dot-matrix comparisons of sets of expansion segments reveal high similarities between members of a set within any 28S rRNA gene of a species, in contrast to the little or spurious similarity that exists between sets of expansion segments from distantly related species. Similarities among members of a set of expansion segments within any 28S rRNA gene cannot be accounted for by their base-compositional bias alone. In contrast, no significant similarity exists within a set of "core" segments (regions between expansion segments) of any 28S rRNA gene, although core segments are conserved between species. The set of expansion segments of a 26S/28S gene is coevolving as a unit in each species, at the same time as the family of 28S rRNA genes, as a whole, is undergoing continual homogenization, making all sets of expansion segments from all ribosomal DNA (rDNA) arrays in a species similar in sequence. Analysis of DNA simplicity of 26S/28S rRNA genes shows a direct correlation between significantly high relative simplicity factors (RSFs) and sequence similarity among a set of expansion segments. A similar correlation exists between RSF values, overall rDNA lengths, and the lengths of individual expansion segments. Such correlations suggest that most length fluctuations reflect the gain and loss of simple sequence motifs by slippage-like mechanisms. We discuss the molecular coevolution of expansion segments, which takes place against a background of slippage-like and unequal crossing-over mechanisms of turnover that are responsible for the accumulation of interspecific differences in rDNA sequences.
Endoscopic Rehabilitation of Vocal Cord Paralysis with a Silicone Elastomer Suspension Implant (2004)

The use of SSEI is safe. Injection laryngoplasty is easy to perform and avoids cervical scarring. Its results are comparable to those obtained with other techniques, including laryngeal framework surgery, even if there is no standard criterion for the evaluation of voice quality. SSEI injection can reasonably be proposed as a surgical treatment for permanent unilateral vocal cord LP.
Abrikosov vortices in long Josephson junctions (1998)

We have developed a theory of the critical current ${I}_{c}$ of a long Josephson junction in the presence of a finite density of Abrikosov vortices trapped in the electrodes in the immediate vicinity of the plane of the junction. We show that under these conditions the Josephson phase difference can be finite even well inside the junction in such a way as to result in a nonmonotonous dependence of ${I}_{c}$ on the concentration of the perturbing vortices, a behavior at variance with that of a short junction. As the average distance between the vortices decreases, ${I}_{c}$ reaches a maximum. The location, magnitude, and sharpness of this feature are strongly dependent on the ratio $\ensuremath{\psi}{\ensuremath{\lambda}}_{J}{/r}_{0},$ where ${r}_{0}$ and $\ensuremath{\psi}$ are respectively the range and the strength of the effective interaction between the Abrikosov vortices and the Josephson fluxons while ${\ensuremath{\lambda}}_{J}$ is the Josephson penetration length. The results obtained are used to discuss the behavior of the critical current recently observed in Josephson junctions based on Nb films.
A study of conflict in group design activities: implications for computer-supported cooperative work environments (2003)

The authors examine one particular aspect of the group process of software design, namely the interpersonal conflict that occurs within a software design team. Structured observations of the conflict that occurred within a set of team meetings that took place during the requirements-definition phase of an actual software development project form the basis for the analysis. It is shown that conflict is a consistent but fairly small percentage of the group interactions. Issues are not resolved in a top-down manner, and general issues such as project goals and overall design approach tend to resurface at later meetings. The implication of these findings for the design of computer-supported cooperative work environments for software design teams is explored.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A comparative study of <b> <i>Bacillus cereus</i> </b> , <b> <i>Bacillus thuringiensis</i> </b> and <b> <i>Bacillus anthracis</i> </b> extracellular proteomes (2005)

Abstract Bacillus cereus , Bacillus thuringiensis and Bacillus anthracis are closely related species that share a similar genetic background but occupy different ecological niches. Virulence plasmids bearing genes coding for toxins, may explain, at least partly, this specialization. We have compared by 2‐DE in the early stationary phase of growth the extracellular proteomes of three strains of these species that have lost their virulence plasmids. Proteins expected to be secreted or to belong to the cell wall or to the cytosol were found in the three proteomes. For the cell wall and cytosolic proteins located in the extracellular space, the three proteomes were similar. Cytosolic proteins included enolase, GroEL, PdhB, PdhD, SodA and others. Cell surface proteins were mainly autolysins, proteases, nucleotidases and OppAs. In contrast, the secreted proteins profiles of B. cereus and B. thuringiensis were quite different from that of B. anthracis . B. cereus and B. thuringiensis extracellular proteomes both contained large amounts of secreted degradative enzymes and toxins, including nine proteases, three phospholipases, two haemolysins and several enterotoxins. Most of the genes encoding these enzymes and toxins are controlled by the transcriptional activator PlcR. The extracellular proteome of the pXO1 ‐ , pXO2 ‐ B. anthracis 9131 strain contained only one secreted protein: the metalloprotease InhA1, also found in the proteomes of the two other strains and possibly involved in antibacterial peptide degradation.
Clinical Control of Diabetes by the Artificial Pancreas (1974)

An artificial pancreas capable of maintaining blood sugar homeostasis within the physiological range is described in this paper. The blood sugar is continuously monitored and then interpreted by a minicomputer which in turn controls and implements the delivery of insulin (or glucose). The entire system is automatic and by giving insulin according to a projected blood sugar level the pattern of insulin administration is similar to the biphasic response of the normal pancreas. Five parameters for control can be selected and altered at will so that any level of normoglycemia can be maintained. Hypoglycemia is not encountered, and none of the patients experienced any side effects during or after the trials. The clinical trials involved a two-day study. On the first day the blood sugar profiles were monitored throughout the day. The patients were given their usual doses of subcutaneous insulin and ate measured meals and snacks. On the second day, they received no subcutaneous insulin; insulin was administered intravenously in accordance with the moment-to-moment requirements of the patients who were given meals the same as those of the previous day. Graphs plotted on a common time scale compare the blood sugar patterns on the two successive days and show the significant improvement in blood sugar homeostasis achieved by this artificial pancreas.
Laser scanning cytometer (LSC) analysis of fraction of labelled mitoses (FLM) (1996)

In this report we describe the successful application of a novel microscope-based multiparameter laser scanning cytometer (LSC) to measure duration of different phases of cell cycle in HL-60 human leukaemic cell lines by the fraction of labelled mitoses (FLM) method. Exponentially growing cells were harvested after various time intervals following pulse-labelling with 5'-bromo-2'-deoxyuridine (BrdUrd), cytocentrifuged, fixed in ethanol, and then exposed to UV light to induce DNA strand breaks at the sites of incorporated BrdUrd. The 3' OH termini of the photolytically generated DNA strand breaks were labelled with BrdUTP in the reaction catalysed by exogenous terminal deoxynucleotidyl transferase (TdT), followed by FITC-labelled BrdUrd antibodies. DNA was counterstained with propidium iodide (PI). Due to differences in chromatin structure between the interphase and mitotic cells, the LSC identified the latter by virtue of their higher red (PI) fluorescence intensity values among all pixels over the measured cell. To confirm that the cells selected were indeed cells in mitosis, predominantly in metaphase, the recorded X-Y coordinates of selected cells were used to re-position the cell for their visual examination. From the time lapse analysis of percentage BrdUrd-labelled cells progressing through mitosis it was possible to calculate the duration of individual phases of the cell cycle. The duration of S (Ts) and G2 + M (TG2 + M) was 8 and 3 h, respectively, and the minimal duration of G2 (TG2) was 2 h. The cell cycle time (Tc) estimated for the cohort of the most rapidly progressing cells was 13 h. The ability to automatically and rapidly discriminate mitotic cells combined with the possibility of their subsequent identification by image analysis makes LSC the instrument of choice for the FLM analysis.
Influence of Surgical Manipulation on Prostate Gene Expression: Implications for Molecular Correlates of Treatment Effects and Disease Prognosis (2006)

Surgical manipulation results in significant gene expression changes. Molecular analyses of surgical samples should recognize that transcript alterations occur rapidly, and these results are important when designing and analyzing molecular correlates of clinical studies.
Uluru Statement has lit a fuse that cannot go out (2017)

On Sorry Day, marking the tabling of the Bringing Them Home report, a historical event occurred in the heart of Australia. Following months of consultation meetings around the country, a delegation of Aboriginal and Torres Strait Islander Australians handed down the Uluru Statement from the Heart.
Nucleated Polymerisation in the Presence of Pre-Formed Seed Filaments (2011)

We revisit the classical problem of nucleated polymerisation and derive a range of exact results describing polymerisation in systems intermediate between the well-known limiting cases of a reaction starting from purely soluble material and for a reaction where no new growth nuclei are formed.
Cardiovascular drugs. 5. 1-Amino-3-phenoxy-2-propanol derivatives as .beta.-adrenergic blocking agents (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCardiovascular drugs. 5. 1-Amino-3-phenoxy-2-propanol derivatives as .beta.-adrenergic blocking agentsMichio Nakanishi, Tomio Muro, Yasuaki Chihara, Hiroshi Imamura, and Tooru NakaoCite this: J. Med. Chem. 1972, 15, 1, 45–48Publication Date (Print):January 1, 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://pubs.acs.org/doi/10.1021/jm00271a013https://doi.org/10.1021/jm00271a013research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Protection of Copper Corrosion by an Ultrathin Two‐Dimensional Polymer Film of Alkanethiol Monolayer (1998)

An ultrathin (ca. 5.6 nm thick), closely packed (self‐assembly), tightly interconnected (two‐dimensional polymer), and water‐repellent (>130° of the contact angle with water) film was prepared by modification of an 11‐mercapto‐1‐undecanol self‐assembled monolayer adsorbed on a copper surface with 1,2‐bis(trichlorosilyl)ethane and subsequently with octadecyltrichlorosilane at for 24 h. This film prevented copper corrosion in aerated 0.5 M with the protective efficiency, P, of the film being maintained at over 95% in the solution for 15 h. The film provided excellent protection against indoor atmospheric corrosion of copper for 300 days. Effects of the surface roughness on the water repellence of the surface covered with the film and on the P value of an unmodified or modified alkanethiol monolayer were studied by using atomic force microscopy to examine mechanically abraded and electropolished copper surfaces.
Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C. (1988)

Both 1,2-diacyl- and 1-O-alkyl-2-acyl-sn-glycerols are released during stimulation of human polymorphonuclear leukocytes (PMNL). 1,2-Diacylglycerols have received intense interest as intracellular "second messengers" due to their ability to activate protein kinase C (Ca2+ phospholipid-dependent enzyme). However, little is known about bioactivities of the alkylacylglycerols. This study compared the ability of 1,2-diacyl- and 1-O-alkyl-2-acylglycerols to modulate the respiratory burst of stimulated PMNL, a response which depends on the activation of an NADPH oxidase to generate bactericidal species of reduced oxygen. Direct stimulation by N-formyl-Met-Leu-Phe caused an abrupt release of H2O2 which ceased within 2.5 min. Preincubation with diacylglycerols (1-oleoyl-2-acetylglycerol,5-30 microM, and 1,2-dioctanoylglycerol,2-5 microM) caused a decrease in lag time, 3-fold increase in initial rate of H2O2 release, and marked prolongation of the response to N-formyl-Met-Leu-Phe (features characteristic of a priming effect). Preincubation with alkylacylglycerols (1-O-delta 9-octadecenyl-2-acetylglycerol, 5-30 microM, and 1-O-octyl-2-octanoylglycerol, 20-50 microM) primed initiation (shortened lag time and increased velocity) but, in contrast to diacylglycerols, did not alter duration of H2O2 release. While low concentrations of diacylglycerols (5-30 microM) primed PMNL, higher concentrations (greater than or equal to 70 microM) stimulated the cells directly. In contrast, higher (70-100 microM) concentrations of alkylacylglycerols did not prime the responses but, in fact, inhibited priming (especially of duration) induced by diacylglycerol. The high concentrations of alkylacylglycerol also inhibited direct stimulation induced by high concentrations of diacylglycerol. Direct stimulation by high concentrations of diacylglycerol probably involves activation of protein kinase C, whereas alkylacylglycerol was found to inhibit activation of protein kinase C by diacylglycerol in vitro. Thus, diacylglycerols are complete priming agonists, altering both rate and duration of the response. In contrast, alkylacylglycerols may have biphasic, concentration-related effects in modulation of functions of PMNL. At low concentrations, they may facilitate initiation of functional events; however, as their concentration increases, they may serve to terminate responses. The distinct priming effects of these diglycerides also reveal that priming can involve at least two distinct events: 1) initiation and 2) prolongation.(ABSTRACT TRUNCATED AT 400 WORDS)