gebhart/patrepeval huggingface dataset:
Time series motif discovery: dimensions and applications (2014)

Time series motifs are repeated segments in a long time series that, if exist, carry precise information about the underlying source of the time series. Motif discovery in time series data has received significant attention in the data mining community since its inception, principally because, motif discovery is meaningful and more likely to succeed when the data is large . Algorithms for motif discovery generally deal with three aspects the definition of the motifs, domain based preprocessing, and finally, the algorithmic steps. Typical definitions of motifs signify the similarity or the support of the motifs. Domains impose preprocessing requirements to meaningful motif finding such as data alignment, interpolation, and transformation. Motif discovery algorithms vary based on exact or approximate evaluation of the definition. In addition, algorithms require different representations [Symbolic Aggregate approXimation (SAX), DFT etc.] and similarity measures [correlation, dynamic time warping (DTW) distance etc.] for time series segments. In this paper, we discuss these three facets in detail with examples taken from the literature. We briefly describe a set of applications of time series motif in various domains and elaborate on a certain application in entomology to analyze insect behavior. This article is categorized under: Algorithmic Development > Spatial and Temporal Data Mining Technologies > Structure Discovery and Clustering
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes (2016)

Following the recent discovery that heme proteins can catalyze the cyclopropanation of styrenyl olefins with high efficiency and selectivity, interest in developing new enzymes for a variety of non-natural carbene transfer reactions has burgeoned. The fact that diazo compounds and other carbene precursors are known mechanism-based inhibitors of P450s, however, led us to investigate if they also interfere with this new enzyme function. We present evidence for two inactivation pathways that are operative during cytochrome P450-catalyzed cyclopropanation. Using a combination of UV-vis, mass spectrometry, and proteomic analyses, we show that the heme cofactor and several nucleophilic side chains undergo covalent modification by ethyl diazoacetate (EDA). Substitution of two of the affected residues with less-nucleophilic amino acids led to a more than twofold improvement in cyclopropanation performance (total TTN). Elucidating the inactivation pathways of heme protein-based carbene transfer catalysts should aid in the optimization of this new biocatalytic function.
DNA Origami-Based Förster Resonance Energy-Transfer Nanoarrays and Their Application as Ratiometric Sensors (2018)

DNA origami nanostructures provide a platform where dye molecules can be arranged with nanoscale accuracy allowing to assemble multiple fluorophores without dye–dye aggregation. Aiming to develop a bright and sensitive ratiometric sensor system, we systematically studied the optical properties of nanoarrays of dyes built on DNA origami platforms using a DNA template that provides a high versatility of label choice at minimum cost. The dyes are arranged at distances, at which they efficiently interact by Förster resonance energy transfer (FRET). To optimize array brightness, the FRET efficiencies between the donor fluorescein (FAM) and the acceptor cyanine 3 were determined for different sizes of the array and for different arrangements of the dye molecules within the array. By utilizing nanoarrays providing optimum FRET efficiency and brightness, we subsequently designed a ratiometric pH nanosensor using coumarin 343 as a pH-inert FRET donor and FAM as a pH-responsive acceptor. Our results indicate that the sensitivity of a ratiometric sensor can be improved simply by arranging the dyes into a well-defined array. The dyes used here can be easily replaced by other analyte-responsive dyes, demonstrating the huge potential of DNA nanotechnology for light harvesting, signal enhancement, and sensing schemes in life sciences.
Radiofrequency Thermal Ablation in Canine Femur: Evaluation of Coagulation Necrosis Reproducibility and MRI-Histopathologic Correlation (2005)

Radiofrequency ablation created well-defined coagulation necrosis in a reproducible manner, and MRI accurately determined the extent of the radiofrequency-induced thermal bone injury.
REDUCTION OF CARBON DIOXIDE TO METHANOL BY LITHIUM ALUMINUM HYDRIDE (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTREDUCTION OF CARBON DIOXIDE TO METHANOL BY LITHIUM ALUMINUM HYDRIDERobert F. Nystrom, William H. Yanko, and Weldon BrownCite this: J. Am. Chem. Soc. 1948, 70, 1, 441Publication Date (Print):January 1, 1948Publication History Published online1 May 2002Published inissue 1 January 1948https://pubs.acs.org/doi/10.1021/ja01181a536https://doi.org/10.1021/ja01181a536research-articleACS PublicationsRequest reuse permissionsArticle Views592Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Software implementation of ultrasound beamforming using ADSP-TS201 DSPs (2008)

We present a software-based ultrasound beamformer to build a fully software-based ultrasound scanner which performs real-time delay-sum beamforming using fractional delay filters using ADSP-TS201 DPSs (Analog Device Inc.). Receive dynamic focusing generally requires fast transfer of a large amount of data for inter-channel summation and for delay control. The DSPs are connected in pipelined network architecture without a glue logic using the DPS's parallel ports, which allows the connection of unlimited DSPs. Each DSP has a small input FIFO which takes as input the data samples from each ADC and can take delay values either from a memory (to use pre-calculated delay values) or an external FPGA (for real-time delay calculation) via its LVDS channel. Two fractional delay beamformer (FDBF) schemes are implemented on the DSP system. Each scheme is programmed in assembly code optimized for speed; instruction level parallelism is secured to maximally utilize the four execution units of each DSP, pipeline scheduling is employed to avoid pipeline stall, and instruction reordering techniques are used to prevent memory contention while preserving the program semantics. It is found that dynamic focusing is carried out faster when delay filtering is performed prior to interchannel summation, whereas hardware implementation of the FDBF favors performing delay filtering after interchannel summation. The frame rate achievable with 16 DSPs is up to 28Hz when the sampling rate is 40MHz, the view depth is 20cm, the number of scanline is 128, and the number of channel is 64.
Lys631 residue in the active site of the bacteriophage T7 RNA polymerase (1991)

A highly selective affinity labeling of T7 RNA polymerase with the o-formylphenyl ester of GMP and [alpha-32P]UTP was carried out. The site of the labeling was located using limited cleavages with hydroxylamine, bromine, N-chlorosuccinimide and cyanogene bromide and was identified as the Lys631 residue. Site-directed mutagenesis using synthetic oligonucleotides was used to substitute Lys631 by a Gly, Leu or Arg residue. Kinetic studies of the purified mutant enzymes showed alterations of their polymerizing activity. For the Lys----Gly mutant enzyme, anomalous template binding was observed.
Carboxylic acid-containing benzoxazines as efficient catalysts in the thermal polymerization of benzoxazines Part A Polymer chemistry (2008)

The autocatalytic thermal polymerization behavior of three benzoxazine monomers containing carboxylic acid functionalities is reported. Several mixtures of these carboxylic monomers and 3-phenyl-3,4-dihydro-2H-1,3-benzoxazine were prepared and their thermal polymerization behavior was analyzed by differential scanning calorimetry. The acid character of these reactive monomers increases the concentration of oxonium species, thus catalyzing the benzoxazine ring opening reaction. In this way the polymerization temperature decreased by as much as 100 °C in some cases. The existence of decarboxylation processes at high temperatures has been established by FTIR-ATR and related to the increase in thermal stability observed by TGA in some cases. A relationship between the presence of carboxylic groups in the resulting materials and their flame retardancy behavior has also been established.
Validación del sistema euroscore para cirugía cardíaca en la ciudad de Córdoba (2010)

Background:. We recommend the use of models to estimate mortality hospital risk in cardiac surgery (CC). The aim of this study was to validate a risk stratification system, widely used as the EuroSCORE (ES), in our institution.Material and methods: We retrospectively analyzed the records of patients undergoing CC consecutively between January 2006 and November 2008. The ES was calculated retrospectively based on data from medical records. Mortality was considered until the time of discharge. In all patients, the ES was calculated by logistic and additive. To study the validity of the model, we analyzed their ability to calibration and discrimination through the goodness of fit test of Hosmer and Lemeshow and area underResults: 153 patients were included, mean age 64.1 ± 9.5 years, 77.8% men. The CRM was 60.8%, 24.8% and 14.4% valvular surgery combined (bypass + valve). Overall mortality was 3.9%. The area under the curve of the logistic model was 0.87 and the Hosmer Lemeshow test was 0.84. The area under the curve of the additive model was 0.86 and the Hosmer Lemeshow test was p = 0.89. A score greater than 7 points is additive had a sensitivity of 66% and 91,5% specificity for predicting hospital mortality.Conclusion: The ES is a useful model and can be used to estimate the risk of hospital mortality in CC in the city of Cordoba.
Alteration of the Glucagon Axis in GPR120 (FFAR4) Knockout Mice (2014)

GPR40 (FFAR1) and GPR120 (FFAR4) are G-protein-coupled receptors (GPCRs) that are activated by long chain fatty acids (LCFAs). GPR40 is expressed at high levels in islets and mediates the ability of LCFAs to potentiate glucose-stimulated insulin secretion (GSIS). GPR120 is expressed at high levels in colon, adipose, and pituitary, and at more modest levels in pancreatic islets. The role of GPR120 in islets has not been explored extensively. Here, we confirm that saturated (e.g. palmitic acid) and unsaturated (e.g. docosahexaenoic acid (DHA)) LCFAs engage GPR120 and demonstrate that palmitate- and DHA-potentiated glucagon secretion are greatly reduced in isolated GPR120 KO islets. Remarkably, LCFA potentiated glucagon secretion is similarly reduced in GPR40 KO islets. Compensatory changes in mRNA expression of GPR120 in GPR40 KO islets, and vice versa, do not explain that LCFA potentiated glucagon secretion seemingly involves both receptors. LCFA-potentiated GSIS remains intact in GPR120 KO islets. Consistent with previous reports, GPR120 KO mice are hyperglycemic and glucose intolerant; however, our KO mice display evidence of a hyperactive counter-regulatory response rather than insulin resistance during insulin tolerance tests. An arginine stimulation test and a glucagon challenge confirmed both increases in glucagon secretion and liver glucagon sensitivity in GPR120 KO mice relative to WT mice. Our findings demonstrate that GPR120 is a nutrient sensor that is activated endogenously by both saturated and unsaturated long chain fatty acids and that an altered glucagon axis likely contributes to the impaired glucose homeostasis observed in GPR120 KO mice.
Efficient Permeability Parameterization With the Discrete Cosine Transform (2007)

Abstract The inverse estimation of permeability fields (history matching) is commonly performed by replacing the original set of unknown spatially discretized permeabilities with a smaller (lower dimensionality) group of unknowns that captures the most important features of the field. This makes the inverse problem better posed by reducing redundancy. The Karhunen-Loeve Transform (KLT) is a classical option for deriving low dimensional parameterizations for history matching applications. The KLT can provide an accurate characterization of complex permeability fields but it can be computationally demanding. In many respects this approach provides a benchmark that can be used to evaluate the performance of more computationally efficient alternatives. The KLT requires knowledge of the permeability covariance function and can give poor results whenthis matrix does not adequately describe the actual permeability field. By contrast, the Discrete Cosine Transform (DCT) provides a robust parameterization alternative that does not require specification of covariances or other statistics. It is computationally efficient and in many cases is almost as accurate as the KLT. The DCT is able to accommodate prior information, if desired. Here we describe the DCT approach and compare its performance to the KLT for a set of geologically relevant examples.
Isolation and Characterization of Pectin in Sugar‐Beet Pulp (1988)

ABSTRACT Pectin was extracted from sugar‐beet pulp by various solvent fractionation procedures. An optimal HCI‐extraction method yielded 19.53% pectin from the raw material. The HCl‐isolated pectin contained 81.8% galacturonic acid. The sugar‐beet pulp pectin obtained from different extraction procedures had a high methoxy content ( 60% degree of methylation). The pectin also contained 10 to 17.5% neutral sugars which were mainly arabinose and galactose as analyzed by gas chromatography. The peak molecular weights (relative to dextrans) of the pectins as determined by gel permeation ranged from 35,500 to 44,700 daltons. The pectin possessed high water‐holding capacity and low viscosity.
New concepts in pharmacological efficacy at 7<scp>TM</scp>receptors:<scp>IUPHAR R</scp>eview 2 (2012)

The present-day concept of drug efficacy has changed completely from its original description as the property of agonists that causes tissue activation. The ability to visualize the multiple behaviours of seven transmembrane receptors has shown that drugs can have many efficacies and also that the transduction of drug stimulus to various cellular stimulus-response cascades can be biased towards some but not all pathways. This latter effect leads to agonist 'functional selectivity', which can be favourable for the improvement of agonist therapeutics. However, in addition, biased agonist potency becomes cell type dependent with the loss of the monotonic behaviour of stimulus-response mechanisms, leading to potential problems in agonist quantification. This has an extremely important effect on the discovery process for new agonists since it now cannot be assumed that a given screening or lead optimization assay will correctly predict therapeutic behaviour. This review discusses these ideas and how new approaches to quantifying agonist effect may be used to circumvent the cell type dependence of agonism. This article, written by a corresponding member of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR), reviews our current understanding of the interaction of ligands with seven transmembrane receptors. Further information on these pharmacological concepts is being incorporated into the IUPHAR/BPS database GuideToPharmacology.org.
Constructing a fuzzy grammar for syntactic face detection (2002)

This paper presents a structural face detection system. The proposed system consists of three stages; preprocessing, face-components extraction, and final decision-making. In the first stage, image conversion, colour operation, image restoration, and image enhancement are carried out. Face components are extracted in the second stage. A face model is defined, and a fuzzy grammar composed of octal chain codes is used to represent each of the seven face components. The practical limitations of this representation are considered. Structural components are detected, and the possibility degree that the extracted component is a real face component is determined. In the last stage, a commonsense knowledge base is employed for final evaluation. The detected face components and their corresponding possibility degrees allow the human face knowledge base to locate faces in the image and generate a membership degree for that face within the face class. The experimental results obtained using this method are presented.
Benzotriazole a corrosion inhibitor for antiques: Some practical surface chemistry (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBenzotriazole a corrosion inhibitor for antiques: Some practical surface chemistryRobert Walker Cite this: J. Chem. Educ. 1980, 57, 11, 789Publication Date (Print):November 1, 1980Publication History Received3 August 2009Published online1 November 1980Published inissue 1 November 1980https://doi.org/10.1021/ed057p789RIGHTS & PERMISSIONSArticle Views430Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alertsclose Get e-Alerts
Richard Feynman and computation (1999)

The enormous contribution of Richard Feynman to modern physics is well known, both to teaching through his famous Feynman Lectures on Physics, and to research with his Feynman diagram approach to quantum field theory and his path integral formulation of quantum mechanics. Less well known perhaps is his long-standing interest in the physics of computation and this is the subject of this paper. Feynman lectured on computation at Caltech for most of the last decade of his life, first with John Hopfield and Carver Mead, and then with Gerry Sussman. The story of how these lectures came to be written up as the Feynman Lectures on Computation is briefly recounted. Feynman also discussed the fundamentals of computation with other legendary figures of the computer science and physics community such as Ed Fredkin, Rolf Landauer, Carver Mead, Marvin Minsky and John Wheeler. He was also instrumental in stimulating developments in both nanotechnology and quantum computing. During the 1980s Feynman re-visited long-standing interests both in parallel computing with Geoffrey Fox and Danny Hillis, and in reversible computation and quantum computing with Charles Bennett, Norman Margolus, Tom Toffoli and Wojciech Zurek. This paper records Feynman's links with the computational community and includes some reminiscences about his involvement with the fundamentals of computing.
Technology of Automated Rendezvous and Capture in Space (1999)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Polysulfide dissolution control: the common ion effect (2012)

A Li-sulfur cell with a high discharge capacity of over 1300 mAh g(-1) at a C/10 rate, and a controlled overcharge amount less than 1%, was manufactured by synthesizing a carbon-sulfur nano-composite via a wet milling process, and suppressing polysulfide dissolution using an electrolyte with a highly concentrated lithium salt.
Role of HER receptors family in development and differentiation (2004)

Members of the epidermal growth factor receptor family of receptor tyrosine kinases play a critical role in both development and oncogenesis. The latter is suggested by the frequent overexpression of HER-2, EGFR, and HER-3 in some human carcinomas, primarily breast and squamous cancer. The biological activities of the EGFR family are exerted through various ligand-receptor and receptor-receptor interactions. One receptor that plays a central role in this signaling network is HER-2/Neu, which is considered the preferred heterodimerization partner for other members of the EGFR family. The role of these receptors and their ligands in development is discussed, with particular emphasis on their ability to mediate a variety of pathways and cellular responses, including proliferation, differentiation, and apoptosis.
Matrix Algorithms in Signal Processing (1990)

Abstract : A final report describes the results obtained under the contract title, Matrix Algorithms in Signal Processing. A number of algorithms are described which have the properties that they are numerically stable, robust, and useful. A basic tool for many of these algorithms is the Lanczos class of algorithms. These algorithms have the virtue that they can be used in a dynamic environment and require little storage. Abstracts of several of the reports are included. (Author) (kr)
Clinical trials in systemic sclerosis: lessons learned and outcomes (2007)

The pathogenesis of systemic sclerosis (SSc) is complex and largely unclear. The clinical heterogeneity of the disease and its progression over a number of years makes the choice of endpoints in the design of clinical trials difficult. The overwhelming need in this disease is to diagnose it early and identify those patients who will benefit most from early, aggressive treatment that potentially can alter the clinical disease course. To achieve this, innumerable challenges must be overcome. This article reviews data from recent clinical trials and the lessons derived from retrospective observational studies, databases, and patient registries. Taken together, these observations will help to improve our understanding of the diverse clinical course of SSc and permit refinement of existing outcome measures for the design of future clinical trials, in which the likelihood of observing a positive treatment effect with the drugs at our disposal will be maximized.
Harbin - at last!! (2005)

Harbin was originally a small town on the Songhua River, which was later enlarged with a large influx of Russians in 1917. Although these inhabitants have long gone, their early 20th century buildings, create a unique feel for this area of the city.