gebhart/patrepeval huggingface dataset:
Fabrication tolerances of SOI based directional couplers and ring resonators (2013)

In this work the effect of deviations of the waveguide shape introduced by manufacturing tolerances on the performance of lateral directional couplers and ring resonators based on SOI-rib-waveguides are investigated by using Full Wave 3D Finite Element Method. Beside dimensional deviations like waveguide width and slab thickness for the first time the influence of waveguide sidewall angle and wet chemical cleaning procedures on the device performance are carefully analyzed. Efficient measures against systematic process tolerances are proposed and possible actions to improve device stability and reproducibility are discussed.
Application of Polymeric N-Acetyl-D-Glucosamine (Chitin) to Veterinary Practice. (1993)

The sponge-, cotton-, and flake-type remedies made of chitin (chitin-sponge, chitin-cotton, and chitin-flake, respectively), and non-woven fabric of polyester (NWF) composited with chitin (chitin-NWF) were applied to various types of trauma, abscess, surgical tissue defect and herniorrhaphy in 147 clinical cases including 72 dogs, 38 cows, 33 cats, 2 rabbits, one monkey and one horse. Chitin-sponge was applied in 30 cases as filling agent of surgical tissue defect, and in 25 cases of trauma, 31 cases of abscess as wound dressing or tissue defect filling agent. In 77 out of 86 cases (89.5%), good healing developed. When chitin-sponge was buried in surgical tissue defects due to oncotomy in 20 cases, recurrence of the tumor developed in one case on one month post-operatively, but was not recognized for 3-24 months in 19 cases. Chitin-NWF was applied in 2 cases of trauma and 12 cases of abscess as wound dressing or tissue defect filling agent, 6 cases as filling agent of surgical tissue defect, and 12 cases of umbilical hernia as prosthesis of suture site of hernia ring. In 28 out of 32 cases (87.5%), good healing developed. Chitin-cotton was applied in 8 cases of trauma and 12 cases of abscess as wound dressing or tissue defect filling agent. In 18 out of 20 cases (90.0%), good healing developed. Chitin-flake was applied in 9 cases of trauma as wound dressing or tissue defect filling agent. In 8 out of 9 cases (88.9%), good healing developed. In all cases, no side effects were observed.
Novel Recombinant Hemoglobin, rHb (βN108Q), with Low Oxygen Affinity, High Cooperativity, and Stability against Autoxidation (2000)

Using our Escherichia coli expression system, we have constructed rHb (beta N108Q), a new recombinant hemoglobin (rHb), with the amino acid substitution located in the alpha(1)beta(1) subunit interface and in the central cavity of the Hb molecule. rHb (beta N108Q) exhibits low oxygen affinity, high cooperativity, enhanced Bohr effect, and slower rate of autoxidation of the heme iron atoms from the Fe(2+) to the Fe(3+) state than other low-oxygen-affinity rHbs developed in our laboratory, e.g., rHb (alpha V96W) and rHb (alpha V96W, beta N108K). It has been reported by Olson and co-workers [Carver et al. (1992) J. Biol. Chem. 267, 14443-14450; Brantley et al. (1993) J. Biol. Chem. 268, 6995-7010] that the substitution of phenylalanine for leucine at position 29 of myoglobin can inhibit autoxidation in myoglobin and at position 29 of the alpha-chain of hemoglobin can lower NO reaction in both the deoxy and the oxy forms of human normal adult hemoglobin. Hence, we have further introduced this mutation, alpha L29F, into beta N108Q. rHb (alpha L29F, beta N108Q) is stabilized against auto- and NO-induced oxidation as compared to rHb (beta N108Q), but exhibits lower oxygen affinity at pH below 7.4 and good cooperativity as compared to Hb A. Proton nuclear magnetic resonance (NMR) studies show that rHb (beta N108Q) has similar tertiary structure around the heme pockets and quaternary structure in the alpha(1)beta(1) and alpha(1)beta(2) subunit interfaces as compared to those of Hb A. The tertiary structure of rHb (alpha L29F, beta N108Q) as measured by (1)H NMR, especially the alpha-chain heme pocket region (both proximal and distal histidyl residues), is different from that of CO- and deoxy-Hb A, due to the amino acid substitution at alpha L29F. (1)H NMR studies also demonstrate that rHb (beta N108Q) can switch from the R quaternary structure to the T quaternary structure without changing ligation state upon adding an allosteric effector, inositol hexaphosphate, and reducing the temperature. On the basis of its low oxygen affinity, high cooperativity, and stability against autoxidation, rHb (beta N108Q) is considered a potential candidate for the Hb-based oxygen carrier in a blood substitute system.
An Internal Model for Sensorimotor Integration (1995)

On the basis of computational studies it has been proposed that the central nervous system internally simulates the dynamic behavior of the motor system in planning, control, and learning; the existence and use of such an internal model is still under debate. A sensorimotor integration task was investigated in which participants estimated the location of one of their hands at the end of movements made in the dark and under externally imposed forces. The temporal propagation of errors in this task was analyzed within the theoretical framework of optimal state estimation. These results provide direct support for the existence of an internal model.
Functional beta3-adrenoceptor in the human heart. (1996)

Beta3-adrenoceptors are involved in metabolism, gut relaxation, and vascular vasodilation. However, their existence and role in the human heart have not been documented. We investigated the effects of several beta-adrenoceptor agonists and antagonists on the mechanical properties of ventricular endomyocardial biopsies. In the presence of nadolol, a beta1- and beta2-adrenoceptor antagonist, isoprenaline produced consistent negative inotropic effects. Similar negative inotropic effects also resulted from the action of beta3-adrenoceptor agonists with an order of potency: BRL 37344 > SR 58611 approximately CL 316243 > CGP 12177. The dose-response curve to BRL 37344-decreasing myocardial contractility was not modified by pretreatment with nadolol, but was shifted to the right by bupranolol, a nonselective beta-adrenoceptor antagonist. Beta3-adrenoceptor agonists also induced a reduction in the amplitude and an acceleration in the repolarization phase of the human action potential. Beta3-adrenoceptor transcripts were detected in human ventricle by a polymerase chain reaction assay. These results indicate that: (a) beta3-adrenoceptors are present and functional in the human heart; and (b) these receptors are responsible for the unexpected negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure.
Recursive Hierarchical DFT Methodology with Multi-level Clock Control and Scan Pattern Retargeting (2016)

The value of hierarchical DFT methodologies is well established today. Generating scan patterns at the core level to determine coverage and debug pattern issues is a common practice in today's large SoCs. However, the pattern mapping process from core to chip level has remained an error-prone task that requires significant verification effort. This leads many SoC designers to regenerate patterns at the SoC level and not fully realize the benefits of a hierarchical approach. Since the introduction of automated pattern mapping by EDA tool vendors, leveraging the hierarchical approach has become easier. In this paper we present a multi-level clock control architecture that enables deployment of recursive hierarchical DFT with scan pattern retargeting at multiple levels. The resulting silicon-proven implementation demonstrates ATPG runtime speed-up and memory savings of 10X. Test coverage is maintained and test pattern count is reduced while DFT tapeout schedule is significantly improved.
Pitch and alignment in the perception of tone and intonation : pragmatic signals and biological codes (2004)

In this paper a case is made for examining tone perception and particularly phenomena of tonal alignment in terms of perceptual limitations to pitch processing. The perception of pitch and tonal movement is discussed in relationship to research on alignment. Results from perception experiments using Swedish listeners and non-scripted speech production data from Swedish speakers are used to exemplify the discussion. The results of these experiments are further discussed in terms of biological codes. Finally thresholds of tonal movement perception are proposed based on principles of syllable alignment consistent with perceptual constraints including cognitive processing. 1. Perceptual constraints in tonal processing There is currently considerable interest in examining the
A lymphokine resembling transfer factor that stimulates MIF production by nonsensitive lymphocytes. (1981)

Abstract High potency preparations of a new heat-labile, low m.w. (less than 5000) lymphokine (LMWL) were obtained by culturing tuberculin-sensitive guinea pig peritoneal exudate cells (PEC) with PPD in geometric conditions that promote amplified lymphokine production. This LMWL has the ability, in the presence of PPD, to stimulate nonsensitive PEC to produce a heat-stable molecule(s) resembling MIF with a m.w. in the range 50,000 to 100,000. The effects of the LMWL (less than 5000 daltons) and the MIF-like molecule(s) (50,000 to 100,000 daltons) were defined by the indirect macrophage migration assay and a macrophage deoxyglucose uptake assay. It is possible that LMWL represents a form of transfer factor with the ability to recruit unsensitized lymphocytes to produce MIF.
Activation of ATP-sensitive K<sup>+</sup>(K<sub>ATP</sub>) channels by H<sub>2</sub>O<sub>2</sub>underlies glutamate-dependent inhibition of striatal dopamine release (2003)

In many cells, ATP-sensitive K+ channels (KATP channels) couple metabolic state to excitability. In pancreatic beta cells, for example, this coupling regulates insulin release. Although KATP channels are abundantly expressed in the brain, their physiological role and the factors that regulate them are poorly understood. One potential regulator is H2O2. We reported previously that dopamine (DA) release in the striatum is modulated by endogenous H2O2, generated downstream from glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor activation. Here we investigated whether H2O2-sensitive KATP channels contribute to DA-release modulation by glutamate and gamma-aminobutyric acid (GABA). This question is important because DA-glutamate interactions underlie brain functions, including motor control and cognition. Synaptic DA release was evoked by using local electrical stimulation in slices of guinea pig striatum and monitored in real time with carbon-fiber microelectrodes and fast-scan cyclic voltammetry. The KATP-channel antagonist glibenclamide abolished the H2O2-dependent increase in DA release usually seen with AMPA-receptor blockade by GYKI-52466 [1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride] and the decrease in DA release seen with GABA-type-A-receptor blockade by picrotoxin. In contrast, 5-hydroxydecanoate, a mitochondrial KATP-channel blocker, was ineffective, as were sulpiride, a D2-receptor antagonist, and tertiapin, a G protein-coupled K+-channel inhibitor. Diazoxide, a sulfonylurea receptor 1 (SUR1)selective KATP-channel opener, prevented DA modulation by H2O2, glutamate, and GABA, whereas cromakalim, a SUR2-selective opener, did not. Thus, endogenous H2O2 activates SUR1-containing KATP channels in the plasma membrane to inhibit DA release. These data not only demonstrate that KATP channels can modulate CNS transmitter release in response to fast-synaptic transmission but also introduce H2O2 as a KATP-channel regulator.
Intracranial regression of an advanced basal cell carcinoma using sonidegib and itraconazole after failure with vismodegib (2017)

Locally advanced or metastatic basal cell carcinoma (BCC) has traditionally been difficult to treat. Options for unresectable tumors have been limited to cisplatin-based chemotherapy or palliative radiation therapy. With the advent of molecularly targeted drugs to the hedgehog (Hh) pathway, another option is now available. In some cases, these new drugs have already provided patients with significant increases in overall survival rates.1,2
Childhood myocarditis associated with Chlamydia trachomatis infection (1981)

Paired serum samples from six children with mild to fatal myocarditis have been studied in the microimmunofluorescence test for antibodies against<i>Chlamydia trachomatis</i>. Two patients with other known causes of myocarditis had no antibodies. The other four patients each had<i>C trachomatis</i>antibody. Two had high titer rises, and two with onset one to three months before the first serum sample was taken had level antibody titers. The study of serum from myocarditis patients was unplanned; they were part of a group of paired serum samples from children that had been submitted to the laboratory for viral diagnostic studies during a 16-month period. While the association of<i>C trachomatis</i>antibody with myocarditis was unexpected, it is consistent with the known etiologic role of<i>C psittaci</i>in myocarditis and the widening spectrum of systemic diseases caused by<i>C trachomatis</i>. Since<i>Chlamydia</i>can be treated with antibiotics, the possible etiologic association with myocarditis has important therapeutic ramifications. (<i>JAMA</i>1981;246:2823-2827)
A texture energy measurement technique for 3D volumetric data (2009)

Recent advancements of 3D computer graphics hardware systems have made possible the handling of 3D volumetric data, and the amount of the available data has increased for various scientific fields. This paper proposes a pattern feature extraction method for 3D volumetric data. Pattern features are important for systems which require segmentation and classification. In this paper, the laws texture energy approach is extended so that both 2D image data and 3D volumetric data can be handled. The laws texture energy approach is a powerful technique for describing pattern features of 2D texture images, and it has been applied to various software applications. Our extension of the laws texture energy approach enables direct extractions of pattern features from 3D volumetric data. Although the three dimensional extension increases the number of pattern features, the pattern features are reduced by combining similar pattern features. Our simulation software program attempts to reduce the number of shape features. The program rotates each feature along the x, y and z axes. The rotated features are evaluated if they are identical to other features, and the identical features are combined together to reduce the number of pattern features. For the experiments, artificially synthesized 3D solid textures are analyzed by using the 3D extended laws features, and solid textures are classified by linear discriminant analysis (LDA). Our preliminary experiments show that the three dimensional extension of the laws texture energy approach successfully classifies a certain database of 3D volumetric data.
The Research of M-Learning Platform Based on 4G Network (2014)

By analyzing mobile learning application mode of 4G network, combining with the technical characteristics of 4G network , a mobile learning system based on 4G was proposed. We described the architecture of system and found a solution to the flexibility question of multimedia service development in mobile learning.
THE INFLUENCE OF SERUM LDL-CHOLESTEROL AND HDL- CHOLESTEROL ON SYSTOLIC BLOOD PRESSURE OF TYPE II DIABETIC PATIENTS WITH VARIOUS KIDNEYS FUNCTION NOT YET ON DIALYSIS (2006)

Background: This study was undertaken to elucidate whether and how in patients with type II diabetes the serum lipid concentrations affect the blood pressure of the patients. Methods: Blood pressure (BP) of the patients were measured. For patients glycosylated hemoglobin (HbA1c ) and serum lipids consisting of Triglycerides, cholesterol, High density lipoproteinwere measured using standard methods. Serum LDL-was calculated. Results: The present study included 122 patients (f=82, m=40). The mean patient's age was 63 (Â±10) years. The mean length of the time they were diabetic was 7.4 (Â±5.8) years (median: 6 years). The duration of hypertension was 3.2 (Â±4.6) years (median: 96 months). The mean serum LDL-chol was 112(Â±37) mg/dl (median: 112 mg/dl). The mean serum HDL-c was 47(Â±18) mg/dl (median: 44 mg/dl) .In this study a significant inverse correlation of serum HDL with mean systolic BP.In this study also a significant positive correlation of serum LDL-c with mean systolic BP was found too. Conclusion: This study has important implications for the increased susceptibility to vascular disease associated with LDL-c in diabetic patients. Hence, higher plasma concentrations of LDL-c though with in the normal range, could be an independent risk factor for developing hypertension or its aggravation. This study addressed the hypothesis the new therapeutic methods like statin groups may be identified to reduce LDL-C levels, which may prove to be useful in diabetic patients even inearlier onset of type II diabetes .
Athermalization of Optical Systems* (1948)

Equations are given for the condition that the focal surface of a lens system remain at a predetermined position for a range of ambient temperatures. Simple methods of satisfying these equations for lens systems composed predominantly or entirely of plastic components are described.
Room temperature growth of biaxially aligned yttria-stabilized zirconia films on glass substrates by pulsed-laser deposition (2003)

Room temperature deposition of biaxially textured yttria-stabilized zirconia (YSZ) films on amorphous glass substrates was successfully achieved by conventional pulsed-laser deposition. The influence of the surrounding gases, their pressure and the deposition time on the structure of the films was studied. A columnar growth process was revealed based on the experimental results. The grown biaxial texture appears as a kind of substrate independence, which makes it possible to fabricate in-plane aligned YSZ films on various substrates.
Nanofiltration of plasma‐derived biopharmaceutical products (2003)

This review presents the current status on the use and benefits of viral removal filtration systems--known as nanofiltration--in the manufacture of plasma-derived coagulation factor concentrates and other biopharmaceutical products from human blood origin. Nanofiltration of plasma products has been implemented at a production scale in the early 1990s to improve margin of viral safety, as a complement to the viral reduction treatments, such as solvent-detergent and heat treatments, already applied for the inactivation of human immunodeficiency virus, hepatitis B and hepatitis C virus. The main reason for the introduction of nanofiltration was the need to improve product safety against non-enveloped viruses and to provide a possible safeguard against new infectious agents potentially entering the human plasma pool. Nanofiltration has gained quick acceptance as it is a relatively simple manufacturing step that consists in filtering protein solution through membranes of a very small pore size (typically 15-40 nm) under conditions that retain viruses by a mechanism largely based on size exclusion. Recent large-scale experience throughout the world has now established that nanofiltration is a robust and reliable viral reduction technique that can be applied to essentially all plasma products. Many of the licensed plasma products are currently nanofiltered. The technology has major advantages as it is flexible and it may combine efficient and largely predictable removal of more than 4 to 6 logs of a wide range of viruses, with an absence of denaturing effect on plasma proteins. Compared with other viral reduction means, nanofiltration may be the only method to date permitting efficient removal of enveloped and non-enveloped viruses under conditions where 90-95% of protein activity is recovered. New data indicate that nanofiltration may also remove prions, opening new perspectives in the development and interest of this technique. Nanofiltration is increasingly becoming a routine step in the manufacture of biopharmaceutical products.
ChemInform Abstract: STUDIES ON 1,3‐BENZOXAZINES. IV. REACTION OF IMIDOYL CHLORIDES OF 1,3‐BENZOXAZINES WITH SULFOXIDES (1981)

Abstract Das Chlorbenzoxazin (I) reagiert bei Raumtemperatur mit Dimethylsulfoxid zu einem Gemisch der Verbindungen (II)‐(IV).
REVIEWS La Création artistique et les promesses de la liberté. Par D'ALLONNESOLIVIER REVAULT. (Collection d'Esthétique, 15). Paris: Klincksieck. 1973. 301 pp. 38 F. (1979)

Journal Article REVIEWS Get access La Création artistique et les promesses de la liberté. Par OLIVIER REVAULT D'ALLONNES. (Collection d'Esthétique, 15). Paris: Klincksieck. 1973. 301 pp. 38 F. HENRI GODIN HENRI GODIN BELFAST Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XXXIII, Issue 1, January 1979, Pages 117–118, https://doi.org/10.1093/fs/XXXIII.1.117 Published: 01 January 1979
Identity of a membrane-bound vasoactive intestinal peptide-binding protein with calmodulin. (1992)

A vasoactive intestinal peptide (VIP)-binding protein purified from guinea pig lung membranes (p18) was digested with trypsin, and the amino acid sequence of the peptide fragments was determined. The sequence of six tryptic fragments of p18 was identical with subsequences present in mammalian calmodulin. Authentic porcine brain calmodulin and p18 co-migrated on an sodium dodecyl sulfate-electrophoresis gel and displayed identical chromatographic behavior on a reverse phase high performance liquid chromatography column. The VIP-binding properties of p18 and calmodulin were indistinguishable. Both proteins displayed saturable and apparent high affinity binding of VIP, evidenced by potent inhibition of complexation with [Tyr10-125I]VIP by unlabeled VIP (IC50 = 6.0-8.1 nM). Rat growth hormone releasing factor and a C terminally extended form of VIP ([Leu17]VIP-GKR) also displayed potent inhibition of the binding (IC50 = 6.4 and 4 nM, respectively). These neuropeptides are potential modulators of calmodulin function.
Phosphorylation by Protein Kinase C of the Muscarinic Acetylcholine Receptor (1990)

Muscarinic acetylcholine receptors purified from porcine cerebrum were phosphorylated by protein kinase C purified from the same tissue. More than 1 mol of phosphate was incorporated per mole of receptor, with both serine and threonine residues being phosphorylated. Neither the degree nor the rate of the phosphorylation was affected by the presence or absence of acetylcholine. GTP-sensitive high-affinity binding with acetylcholine was observed for muscarinic receptors reconstituted with GTP-binding proteins (Gi or Go), irrespective of whether muscarinic receptors or the GTP-binding proteins had been phosphorylated by protein kinase C or not. This indicates that the interaction between purified muscarinic receptors and purified GTP-binding proteins in vitro is not affected by their phosphorylation.