gebhart/patrepeval huggingface dataset:
Nonlinear pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation. (1997)

The pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide has been evaluated in 12 patients with metastatic breast cancer undergoing high-dose chemotherapy followed by bone marrow transplantation. Each patient received an initial dose of 4 g/m2 of cyclophosphamide over 90 min to prime peripheral blood progenitor cells (the first course), and 3 weeks later, 6 g/m2 of cyclophosphamide with 800 mg/m2 of thiotepa by 96-hr infusion before marrow stem cell infusion (the second course). Whole blood cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide concentrations were measured by a GC-EIMS method using deuterium labeled compounds as internal standards. In addition, plasma and urine cyclophosphamide concentrations were determined by a GC assay. Whole blood concentrations of cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide vs. time data and urinary excretion of cyclophosphamide data from the first course were co-modeled using a one-compartment model with Michaelis-Menten saturable elimination in parallel with first-order renal elimination (N = 7) or first-order metabolic and renal elimination (N = 5) for cyclophosphamide and one-compartment model with first-order elimination for 4-hydroxycyclophosphamide/aldophosphamide. The parallelism between cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide disposition curves implies that the pharmacokinetics of 4-hydroxycyclophosphamide/aldophosphamide is formation limited; only the fractional 4-hydroxycyclophosphamide/ aldophosphamide clearance rate (Clmet/Fmet) can be estimated. The mean Vmax and Km for cyclophosphamide were 0.78 microM/min and 247 microM, respectively. The mean nonrenal clearance (Clnr) of cyclophosphamide for five patients with apparent first-order elimination of cyclophosphamide was 67 ml/min. The mean Clmet/Fmet of 4-hydroxycyclophosphamide/aldophosphamide was 2982 ml/min. The mean renal clearance (Clr) of cyclophosphamide was 29 ml/min and 24 ml/min for the first course and the second course, respectively. The correlations between cyclophosphamide AUCs and 4-hydroxycyclophosphamide/aldophosphamide AUCs were sought for both drug courses. Blood and plasma cyclophosphamide concentrations were remarkably similar, indicating that cyclophosphamide partitions equally in the red cell and plasma volume. Computer simulation of the effect of potential alterations in Michaelis-Menten saturable elimination and renal clearance on 4-hydroxycyclophosphamide/aldophosphamide has been used to illustrate the complex relationship between the exposure to parent compound and active metabolite.
Easy Lock-Free Indexing in Non-Volatile Memory (2018)

Large non-volatile memories (NVRAM) will change the durability and recovery mechanisms of main-memory database systems. Today, these systems make operations durable through logging and checkpointing to secondary storage, and recover by rebuilding the in-memory database (records and indexes) from on-disk state. A main-memory database stored in NVRAM, however, can potentially recover instantly after a power failure. Modern main-memory databases typically use lock-free index structures to enable a high degree of concurrency. Thus NVRAM-resident databases need indexes that are both lock-free, persistent, and able to recover (almost) instantly after a crash. In this paper, we show how to easily build such index structures. A key enabling component of our scheme is a multi-word compare-and-swap operation, PMwCAS, that is lock-free, persistent, and efficient. PMwCAS significantly reduces the complexity of building lock-free indexes, which we illustrate by implementing both doubly-linked skip lists and the Bw-tree lock-free B+-tree for NVRAM. Experimental results show that PMwCAS's runtime overhead is very low (~4-6% under realistic workloads). This overhead is sufficiently low that the same implementation can be used for both DRAM and NVRAM resident indexes.
Currículum de Gaby Ulate Solís (2009)

Documento adjunto
BioMart: a data federation framework for large collaborative projects (2011)

BioMart is a freely available, open source, federated database system that provides a unified access to disparate, geographically distributed data sources. It is designed to be data agnostic and platform independent, such that existing databases can easily be incorporated into the BioMart framework. BioMart allows databases hosted on different servers to be presented seamlessly to users, facilitating collaborative projects between different research groups. BioMart contains several levels of query optimization to efficiently manage large data sets and offers a diverse selection of graphical user interfaces and application programming interfaces to ensure that queries can be performed in whatever manner is most convenient for the user. The software has now been adopted by a large number of different biological databases spanning a wide range of data types and providing a rich source of annotation available to bioinformaticians and biologists alike.
Study on Performance Testing of Concentric Evacuated Tube Solar Energy Collector System (2005)

Concentric evacuated tube solar energy collector has been interested recently since government has driven to install alternative energy systems in new large building. In this paper, testing of the evacuated tube collector is conducted in outdoor during daytime by transient method. The collector thermal efficiencies are plotted in term of , where is inlet working fluid temperature, is atmospheric temperature and is solar irradiation on the collector surface. The evacuated tube collector efficiency is ranged from 50% to 63% in real outdoor condition. In addition, the total overall heat loss coefficient is found to have an inverse variation to so that the coefficient becomes very high when is small.
Progress on the Biomarkers for Tuberculosis Diagnosis (2011)

Tuberculosis (TB) remains a major threat to global health. Biomarkers derived from pathogen-host interaction can facilitate the monitoring of active TB. The recent progress regarding such biomarkers is summarized, including those can be used from serum, sputum, urine, or breath monitoring. A wide range of potential biomarkers such as protein antigens, cell-free nucleic acids, and lipoarabinomannose were compiled. The possible use of biomarkers for infection identification and monitoring drug efficacy are also presented.
Listerine® Products: An Update on the Efficacy and Safety (2016)

Evidence is accumulating that Listerine® is effective in improving oral health, but the absence of systematic toxicological studies means that an accurate safety assessment cannot be made.
Elements of Web design (1996)

From the Publisher:
Elements of Web Design, 2nd Edition is written for people who know design but just don't know the Web. It describes how your skills can be applied to the exciting world of Web design and introduces the terms, tricks, and technologies you'll need to know to get started. When you're done, you'll have a grasp of every element of Web design, from assembling your team through planning your pages and publishing your site online.
Surgical anatomy of the dorsal nerve of the clitoris (2011)

The detailed description of the distal course of the nerve presented here has not been previously described in adult humans and is pertinent for surgical procedures involving the clitoris.
Influence of the substrate orientation on the electrical and material properties of GaAs metal-oxide-semiconductor capacitors and self-aligned transistors using HfO2 and silicon interface passivation layer (2008)

In this work, we studied the effects of postdeposition anneal (PDA) time and Si interface passivation layer on the material and electrical characteristics of the metal-oxide-semiconductor (MOS) capacitor with high-k (HfO2) material on different orientation substrates with (100), (110), and (311). The interfacial change of HfO2∕Si∕GaAs gate stacks after PDA has been characterized using x-ray photoelectron spectroscopy (XPS) and Dit measurement using conductance method and frequency dispersion. XPS measurement shows the formation of gallium and arsenic oxides with increasing annealing temperature. Unoxidized Si and gallium and arsenic oxides formation in the interface might act as traps. Self-aligned MOS field effect transistors using PDA at 600°C and post-metal-annealing at 800°C have also been fabricated and characterized. The (100) substrate has lower density of interface traps and higher mobility due to reduced Ga2O3 formation.
Evidence That Insulin-Like Growth Factor I and Growth Hormone Are Required for Prostate Gland Development<sup>1</sup> (1999)

Insulin-like growth factor I (IGF-I) has been implicated as a factor that may predispose one to prostate cancer. However, no specific relationship between IGF-I and prostate development or cancer in vivo has been established. To determine whether IGF-I was important in prostate development, we examined prostate architecture in IGF-I(-/-) null mice and wild-type littermates. Glands from 44-day-old IGF-I-deficient animals were not only smaller than those from wild-type mice, but also had fewer terminal duct tips and branch points and deficits in tertiary and quaternary branching (P < 0.0001), indicating a specific impairment in gland structure. Administration of des(1-3)-IGF-I for 7 days partially reversed the deficit by increasing those parameters of prostate development (P < 0.006). That IGF-I production probably mediates an effect of GH in this process was indicated by the observations that GH antagonist transgenic mice also had significantly impaired prostate development (P < 0.0002) and that bovine GH had no independent effect on stimulating prostate development in IGF-I null animals. The data indicate that IGF-I deficiency is the proximate cause of impaired prostate development and give credence to the idea that, like testosterone, GH and IGF-I may be involved in prostate cancer growth as an extension of a normal process.
Hermes: Fast and Energy Efficient Incremental Code Updates for Wireless Sensor Networks (2009)

Wireless reprogramming of sensor nodes is a requirement for long-lived networks due to changes in the functionality of the software running on the nodes. The amount of information that needs to be wirelessly transmitted during reprogramming should be minimized to reduce reprogramming time and energy. In this paper, we present a multi-hop incremental reprogramming protocol called Hermes that transfers over the network the delta between the old and new software and lets the sensor nodes rebuild the new software using the received delta and the old software. It reduces the delta by using techniques to mitigate the effects of function and global variable shifts caused by the software modifications. Then it compares the binary images at the byte level with a method to create small delta. For a wide range of software change scenarios that we experimented with, we find that Hermes transfers up to 201 times less information than Deluge, the standard reprogramming protocol for TinyOS and 64 times less than an existing incremental reprogramming protocol by Jeong and Culler.
Supercritical CO2-Foam - The Importance of CO2 Density on Foams Performance (2013)

Abstract In CO2 projects for enhanced oil recovery (EOR) a critical factor is possible early CO2 breakthrough and consequently poor sweep efficiency. Injection of foam can block and divert CO2 which may improve sweep efficiency. Large changes in physical properties of CO2 with temperature and pressure might affect CO2-foam performance under various reservoir conditions. Recently, we have focused on understanding supercritical CO2-foam properties and this paper describes the importance of supercritical CO2 density on CO2-foam performance in outcrop Berea sandstone core material. Foam flooding experiments were conducted in sandstone core material at different pressures from 30 to 280 bar and at temperatures of 50 and 90&deg;C using an AOSC14/16 surfactant. Results showed high foam strengths at low CO2 density. In fact, the strongest supercritical CO2-foam was generated at the lowest supercritical CO2 density tested, quite comparable to foam strength obtained with gaseous CO2. Only reduced foam strengths were found with dense supercritical CO2 (MRF 3-11). Foam generation was studied with both equilibrated and non-equilibrated fluids. Previously, we showed that CO2-foam stability and blocking ability were strongly reduced when mass transfer occured. In this study delay in foam strength build-up was observed with non-equilibrated fluids. In addition, visual observations of the foam texture indicated larger bubbles. Compared to N2-foams at similar conditions CO2-foams were weaker and showed coarser foam structure.
Resistance gene enrichment sequencing (<scp>R</scp>en<scp>S</scp>eq) enables reannotation of the <scp>NB</scp>‐<scp>LRR</scp> gene family from sequenced plant genomes and rapid mapping of resistance loci in segregating populations (2013)

RenSeq is a NB-LRR (nucleotide binding-site leucine-rich repeat) gene-targeted, Resistance gene enrichment and sequencing method that enables discovery and annotation of pathogen resistance gene family members in plant genome sequences. We successfully applied RenSeq to the sequenced potato Solanum tuberosum clone DM, and increased the number of identified NB-LRRs from 438 to 755. The majority of these identified R gene loci reside in poorly or previously unannotated regions of the genome. Sequence and positional details on the 12 chromosomes have been established for 704 NB-LRRs and can be accessed through a genome browser that we provide. We compared these NB-LRR genes and the corresponding oligonucleotide baits with the highest sequence similarity and demonstrated that ~80% sequence identity is sufficient for enrichment. Analysis of the sequenced tomato S. lycopersicum 'Heinz 1706' extended the NB-LRR complement to 394 loci. We further describe a methodology that applies RenSeq to rapidly identify molecular markers that co-segregate with a pathogen resistance trait of interest. In two independent segregating populations involving the wild Solanum species S. berthaultii (Rpi-ber2) and S. ruiz-ceballosii (Rpi-rzc1), we were able to apply RenSeq successfully to identify markers that co-segregate with resistance towards the late blight pathogen Phytophthora infestans. These SNP identification workflows were designed as easy-to-adapt Galaxy pipelines.
Indicators of the General Price Level and Inflation (1994)

This article examines whether price indexes, such as the CPI, the PPI, and the implicit price deflator for GDP (PGDP), tell a consistent story about the general price level and inflation rate. To this end, Zsolt Becsi analyzes the time series properties of these indexes. He finds that the PGDP has a stable long-term relationship with both of the other price indexes. Some evidence suggests that PGDP and CPI inflation have common long-run trends, while PPI inflation has no discernible stable long-run relationship with either PGDP or CPI inflation. ; Some theories suggest that the price level relevant for monetary policy is broader than price indexes of final goods and services such as the PGDP. This article investigates whether the PGDP captures movements in other price or inflation series. There is weak evidence that the PGDP shares common trends with the price levels and inflation rates of some intermediate goods and assets. Overall, these results suggest that PGDP makes a good indicator of the general price level for monetary policy because it reflects shocks to a broad range of other series.
Evidence That Hydrogen Sulphide Can Modulate Hypothalamo‐Pituitary‐Adrenal Axis Function: <i>In Vitro</i> and <i>In Vivo</i> Studies in the Rat (2000)

The gas hydrogen sulphide (H2S) is normally produced in large amounts in the central nervous system during the metabolism of sulphur-containing aminoacids. H2S was recently shown to influence long-term potentiation in the rat hippocampus; this finding suggested that the gas may act as a neuromodulator in the brain. We therefore tested the effect of the gas on the release of corticotropin-releasing hormone (CRH) from rat hypothalamic explants. CRH immunoreactivity in the incubation media was taken as a marker of peptide release. We found that the addition of NaHS to incubation media was consistently associated with a concentration-dependent decrease in KCl-stimulated CRH release, whereas basal secretion was unaffected. Increased endogenous H2S production may be also obtained using an indirect precursor of H2S formation, S-adenosyl-L-methionine (SAMe). The latter mimicked the effects of NaHS, since it reduced potassium-stimulated CRH release. In vivo, SAMe showed no effect on hypothalamo-pituitary-adrenal (HPA) function under resting conditions, but inhibited stress-related glucocorticoid increase.
Tailored Mesoporosity Development in Zeolite Crystals by Partial Detemplation and Desilication (2008)

Abstract Partial detemplation of zeolites followed by desilication in alkaline medium is demonstrated as a powerful and elegant approach to design hierarchical zeolites with tailored degree of mesoporosity. This achievement, illustrated for large beta crystals, is based on the fact that the template‐containing zeolite is virtually inert to Si leaching upon treatment in aqueous NaOH solutions. Partial removal of the structure‐directing agent creates regions in the crystal susceptible to mesopore formation by subsequent desilication, while template‐containing regions are protected from silicon extraction. Variation of the calcination temperature in the range 230–550 °C determines the amount of template removed and enables control of the extent of mesopore formation in the zeolite (20–230 m 2 g −1 ) upon alkaline treatment. The functionality of the introduced mesoporosity in the hierarchical beta crystals is demonstrated by the improved performance in the catalytic pyrolysis of low‐density polyethylene. The partial detemplation–desilication treatment enhances the tuning options of this demetallation method.
Qualitative Properties of Spray Deposits — Patterns and Statistics (1998)

Pesticides must be applied to the target area uniformly. Uniformity of sprayer output is typically described by the coefficient of variation (CV) of the spray emitted. However, deposit size, number, and concentration interactions are overlooked when using this statistic. A measurement technique and alternative statistics, capable of documenting and separating qualitatively different spray patterns produced by quantitatively similar spray distributions were evaluated. Water and Roundup® Ultra with and without Kinetic™ and AgRhô™ DR 2000 were applied to plastic tape at 93.5 L/ha through XR8O03VS, TT11003VP, and TDVC-03/06 tips. Nigrosin was used as a tracer. Deposits were allowed to dry and were photographed at 2 cm intervals across the swath using an image analysis system. Deposit structure (#/cm2, size distribution and applied volume) was analyzed for each subsample. The data showed that while differences could be shown to occur in individual parameters, better separation of treatments was achieved with the use of the diversity statistics.
Topographical limitations to the metallization of very large scale integrated structures by bias sputtering: Experiments and computer simulations (1986)

Aluminum deposition by radio-frequency bias sputtering on grooves and holes with aspect ratios (depth to width) in the range of 0.5–1.0 was studied experimentally and by computer simulation. The structures with an aspect ratio of up to 0.5 were planarized. Aspect ratios larger than about 0.6 however led to the buildup of cavities within the grooves and holes. This limitation for narrow structures with vertical sidewalls was observed experimentally and was in excellent agreement with the results of the profile simulations. The critical aspect ratio may be increased by using a higher bias potential and slope angles of less than 90°.
Quantitative Evaluation of Human Visual Perception for Multiple Screens and Multiple Codecs (2013)

Great consumer experiences are created by a convergence of sight, sound, and story. This paper presents an in-depth quantitative analysis of the neurobiology and optics of sight. More specifically, it examines how principles of vision science can be used to predict the bit rates and video quality needed to make video on devices ranging from smartphones to ultrahigh-definition televisions (UHDTVs) a success. It presents the psychophysical concepts of simple acuity, hyperacuity, and Snellen acuity to examine the visibility of compression artifacts for the MPEG-4/H.264 video compression standard. It looks at the newest emerging international compression standard for High-Efficiency Video Coding (HEVC). It will investigate how the various sizes of the new coding units in HEVC would be imaged on the retina and what that could mean in terms of the HEVC video quality and bit rates that would likely be needed to deliver entertainment-quality content to smartphones, tablets, high-definition televisions, 4K TVs, and UHDTVs.
Maximising the flux-weakening capability of permanent magnet brushless AC machines and drives (2002)

The behaviour of permanent magnet brushless AC machines, having alternative rotor topologies, viz. surface mounted, inset, interior radial and circumferential magnets, is investigated, when they are designed and operated under the 'infinite' flux-weakening capability condition. The corresponding torque/power-speed characteristics, the demagnetisation withstand capability, the variation of iron losses, and the fault management of the drive and/or machine etc. are analysed.
Arabidopsis <i>RecQl4A</i> suppresses homologous recombination and modulates DNA damage responses (2005)

The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood. RecQ is a family of genes with conserved roles in the regulation of DNA recombination in eukaryotes; there are seven members in Arabidopsis. Here we report on the functional analysis of the Arabidopsis RecQl4A gene. Ectopic expression of Arabidopsis RecQl4A in yeast RecQ-deficient cells suppressed their hypersensitivity to the DNA-damaging drug methyl methanesulfonate (MMS) and enhanced their rate of homologous recombination (HR). Analysis of three recQl4A mutant alleles revealed no obvious developmental defects or telomere deregulation in plants grown under standard growth conditions. Compared with wild-type Arabidopsis, the recQl4A mutant seedlings were found to be hypersensitive to UV light and MMS, and more resistant to mitomycin C. The average frequency of intrachromosomal HR in recQl4A mutant plants was increased 7.5-fold over that observed in wild-type plants. The data reveal roles for Arabidopsis RecQl4A in maintenance of genome stability by modulation of the DNA damage response and suppression of HR.
Channel Equalization Using a Kalman Filter for Fast Data Transmission (1974)

This paper shows how a Kalman filter may be applied to the problem of setting the tap gains of transversal equalizers to minimize mean-square distortion. In the presence of noise and without prior knowledge about the channel, the filter algorithm leads to faster convergence than other methods, its speed of convergence depending only on the number of taps. Theoretical results are given and computer simulation is used to corroborate the theory and to compare the algorithm with the classical steepest descent method.