gebhart/patrepeval huggingface dataset:
Platelet-Derived Growth Factor–Induced p42/44 Mitogen-Activated Protein Kinase Activation and Cellular Growth Is Mediated by Reactive Oxygen Species in the Absence of <i>TSC2</i>/Tuberin (2005)

Tuberous sclerosis complex (TSC) is a genetic disorder caused by inactivating mutations in the TSC1 or TSC2 genes, which encode hamartin and tuberin, respectively. TSC is characterized by multiple tumors of the brain, kidney, heart, and skin. Tuberin and hamartin inhibit signaling by the mammalian target of rapamycin (mTOR) but there are limited studies of their involvement in other pathways controlling cell growth. Using ELT-3 cells, which are Eker rat-derived smooth muscle cells, we show that ELT-3 cells expressing tuberin (TSC2+/+) respond to platelet-derived growth factor (PDGF) stimulation by activating the classic mitogen-activated protein (MAP)/extracellular signal-regulated kinase kinase (MEK)-1-dependent phosphorylation of p42/44 MAP kinase (MAPK) with nuclear translocation of phosphorylated p42/44 MAPK. In contrast, in tuberin-deficient ELT-3 cells (TSC2-/-), PDGF stimulation results in MEK-1-independent p42/44 MAPK phosphorylation with reduced nuclear localization of phosphorylated p42/44 MAPK. Moreover, in TSC2-/- cells but not in TSC2+/+ cells, cellular growth and activation of p42/44 MAPK by PDGF requires the reactive oxygen species intermediate, superoxide anion (O2*-). Both baseline and PDGF-induced O2*- levels were significantly higher in TSC2-/- cells and were reduced by treatment with rapamycin and inhibitors of mitochondrial electron transport. Furthermore, the exogenous production of O2*- by the redox cycling compound menadione induced MEK-1-independent cellular growth and p42/44 MAPK phosphorylation in TSC2-/- cells but not in TSC2+/+ cells. Together, our data suggest that loss of tuberin, which causes mTOR activation, leads to a novel cellular growth-promoting pathway involving mitochondrial oxidant-dependent p42/44 MAPK activation and mitogenic growth responses to PDGF.
The interaction between conjugated polymer and fullerenes (1998)

The fluorescence of Poly(2-methoxy,5-(2′-ethylhexloxy)-p-phenylene-vinylene) (MEH–PPV) quenched by fullerenes was examined, and the results indicate that this quenching is not dynamic. Strong interaction in the excited state between them may be caused by the photoinduced charge transfer and π–π conjugated system interaction. More direct and convincing evidence of the charge transfer complex are presented. © 1998 John Wiley & Sons, Inc. J. Appl. Polym. Sci. 70: 599–603, 1998
An optimizing compiler for GPGPU programs with input-data sharing (2010)

Developing high performance GPGPU programs is challenging for application developers since the performance is dependent upon how well the code leverages the hardware features of specific graphics processors. To solve this problem and relieve application developers of low-level hardware-specific optimizations, we introduce a novel compiler to optimize GPGPU programs. Our compiler takes a naive GPU kernel function, which is functionally correct but without any consideration for performance optimization. The compiler then analyzes the code, identifies memory access patterns, and generates optimized code. The proposed compiler optimizations target at one category of scientific and media processing algorithms, which has the characteristics of input-data sharing when computing neighboring output pixels/elements. Many commonly used algorithms, such as matrix multiplication, convolution, etc., share such characteristics. For these algorithms, novel approaches are proposed to enforce memory coalescing and achieve effective data reuse. Data prefetching and hardware-specific tuning are also performed automatically with our compiler framework. The experimental results based on a set of applications show that our compiler achieves very high performance, either superior or very close to the highly fine-tuned library, NVIDIA CUBLAS 2.1.
SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity (2012)

Chronic inflammation is a major contributing factor in the pathogenesis of many age-associated diseases. One central protein that regulates inflammation is NF-κB, the activity of which is modulated by post-translational modifications as well as by association with co-activator and co-repressor proteins. SIRT1, an NAD(+)-dependent protein deacetylase, has been shown to suppress NF-κB signaling through deacetylation of the p65 subunit of NF-κB resulting in the reduction of the inflammatory responses mediated by this transcription factor. The role of SIRT1 in the regulation of NF-κB provides the necessary validation for the development of pharmacological strategies for activating SIRT1 as an approach for the development of a new class of anti-inflammatory therapeutics. We report herein the development of a quantitative assay to assess compound effects on acetylated p65 protein in the cell. We demonstrate that small molecule activators of SIRT1 (STACs) enhance deacetylation of cellular p65 protein, which results in the suppression of TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner. In an acute mouse model of LPS-induced inflammation, the STAC SRTCX1003 decreased the production of the proinflammatory cytokines TNFα and IL-12. Our studies indicate that increasing SIRT1-mediated NF-κB deacetylation using small molecule activating compounds is a novel approach to the development of a new class of therapeutic anti-inflammatory agents.
Low‐Noise Dynamic Reconstruction for X‐Ray Tomographic Perfusion Studies Using Low Sampling Rates (2009)

Functional imaging based on tomographic X-ray imaging relies on the reconstruction of a temporal sequence of images which accurately reproduces the time attenuation curves of the tissue. The main constraints of these techniques are temporal resolution and dose. Using current techniques the data acquisition has to be performed fast so that the dynamic attenuation values can be regarded as static during the scan. Due to the relatively high number of repeated scans the dose per single scan has to be low yielding a poor signal-to-noise ratio (SNR) in the reconstructed images. In a previous publication a temporal interpolation scheme in the projection data space was relaxing the temporal resolution constraint. The aim of this contribution is the improvement of the SNR. A temporal smoothing term is introduced in the temporal interpolation scheme such that only the physiologic relevant bandwidth is considered. A significant increase of the SNR is achieved. The obtained level of noise only depends on the total dose applied and is independent of the number of scans and the SNR of a single reconstructed image. The approach might be the first step towards using slowly rotating CT systems for perfusion imaging like C-arm or small animal CT scanners.
A Subset of Membrane-Altering Agents and γ-Secretase Modulators Provoke Nonsubstrate Cleavage by Rhomboid Proteases (2014)

Rhomboid proteases are integral membrane enzymes that regulate cell signaling, adhesion, and organelle homeostasis pathways, making substrate specificity a key feature of their function. Interestingly, we found that perturbing the membrane pharmacologically in living cells had little effect on substrate processing but induced inappropriate cleavage of nonsubstrates by rhomboid proteases. A subclass of drugs known to modulate γ-secretase activity acted on the membrane directly and induced nonsubstrate cleavage by rhomboid proteases but left true substrate cleavage sites unaltered. These observations highlight an active role for the membrane in guiding rhomboid selectivity and caution that membrane-targeted drugs should be evaluated for cross-activity against membrane-resident enzymes that are otherwise unrelated to the intended drug target. Furthermore, some γ-secretase-modulating activity or toxicity could partly result from global membrane effects.
A Use Case Based Approach to Feature Models' Construction (2009)

In the research of software reuse, feature models have been widely adopted to organize the requirements of a set of applications in a software domain. However, there still lacks an effective approach to minimizing analysts' participation in feature models' construction. In this paper, we propose a use case based semi-automatic approach to the construction of feature models. The basic idea of this approach is to first construct a set of feature models for individual applications(called application feature models, AFMs) in a software domain, then adjust, and merge the set of AFMs to form a feature model for this domain (called a domain feature model, DFM). The main characteristic of this approach is that it provides a set of rules and algorithms to make the construction of AFMs (from use cases) and the construction of DFMs (by merging a set of AFMs) be carried out automatically. A running example is used to illustrate the main characteristic and the feasibility of this approach.
Early Clinical Factors Predicting the Development of Critical Disease in Japanese Patients with COVID-19: A Single-Center Retrospective, Observational Study (2020)

ABSTRACT Background Insufficient evidence of factors predicting the COVID-19 progression from mild to moderate to critical has been established. We retrospectively evaluated risk factors for critical progression in Japanese COVID-19 patients. Method Seventy-four laboratory-confirmed COVID-19 patients were hospitalized in our hospital between February 20, 2020, and June 10, 2020. We excluded asymptomatic, non-Japanese, and child patients. We divided patients into the stable group (SG) and the progression group (PG) (patients requiring mechanical ventilation). We compared the clinical factors in both groups. We established the cutoff values (COVs) for significantly different factors via receiver operating characteristic (ROC) curve analysis and evaluated risk factors by univariate regression. Results We enrolled 57 COVID-19 patients (median age 52 years, 56.1% male). The median progression time from symptom onset was eight days. Seven patients developed critical disease (PG: 12.2%), two (3.5%) of whom died; 50 had stable disease. Univariate logistic analysis identified elevated lactate dehydrogenase (LDH) (COV: 309 U/l), decreased estimated glomerular filtration rate (eGFR) (COV: 68 ml/min), lymphocytopenia (COV: 980/μl), and statin use as significantly associated with disease progression. However, in Cox proportional hazards analysis, lymphocytopenia at symptom onset was not significant. Conclusions We identified three candidate risk factors for adult Japanese patients with mild to moderate COVID-19: statin use, elevated LDH level, and decreased eGFR.
Sequentially evaporated thin film of Bi and Co-Ni with high coercive force (1984)

The magnetic properties and microstructures of films prepared by sequential evaporation of Bi and pure Co or Co-Ni alloys with up to 60 at.% Ni were investigated. The coercive force of the film rises rapidly with increasing substrate temperature above 100 °C and reaches a maximum at around 150-170°C. The composition of the Co-Ni alloy layer affects the coercive force, with 40 at.% Ni giving the best results. In the layered film of 300 Å thick Co <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">60</inf> Ni <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">40</inf> over 80 A thick Bi, the coercive force HC is 1000 Oe and the squareness ratio Mr/Ms exceeds 0.80. These properties are isotropic and can be adjusted by varying the thicknesses of the magnetic layer and the non-magnetic Bi layer. TEM observation shows that crystallites of the film have no preferred orientation. Examination by Auger Electron Spectroscopy reveals the diffusion of Bi atoms into the magnetic layer.
Hardware synthesis from C/C++ (1999)

Article Hardware synthesis from C/C++ Share on Authors: Abhijit Ghosh Synopsys Inc. Mountain View, CA Synopsys Inc. Mountain View, CAView Profile , Joachim Kunkel Synopsys Inc. Mountain View, CA Synopsys Inc. Mountain View, CAView Profile , Stan Liao Synopsys Inc. Mountain View, CA Synopsys Inc. Mountain View, CAView Profile Authors Info & Claims DATE '99: Proceedings of the conference on Design, automation and test in EuropeJanuary 1999 Pages 82–eshttps://doi.org/10.1145/307418.307529Online:01 January 1999Publication History 18citation325DownloadsMetricsTotal Citations18Total Downloads325Last 12 Months2Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
ChemInform Abstract: Synthesis and Characterization of all‐E (12,12′‐13C2)‐, (13,13′‐13C2)‐, (14,14′‐13C2)‐, (15,15′‐13C2)‐ and (20,20′‐13C2)Astaxanthin. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tapping the Chinese Market: an Examination of Chinese Tourists' Images and Constraints Towards Cruising (2017)

This study examined Chinese tourists' images and constraints towards cruising, and their influences on cruising desires/intentions. Both qualitative and quantitative methodologies were utilized. Based on an extensive literature review, semistructured interviews were conducted to determine measurement items for constructs of interest. Quantitative data were then collected in order to examine the proposed hypotheses. An innovative procedure for developing the best items to be included in the scales was utilized. The results revealed that: 1) images were antecedents of desires and intentions; 2) negative cognitive images have a strong influence on constraints; and 3) constraints were found to have no significant influence on intentions. Both theoretical and practical implications are suggested.
Incorporating Side Information into Recurrent Neural Network Language Models (2016)

Cong Duy Vu Hoang, Trevor Cohn, Gholamreza Haffari. Proceedings of the 2016 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies. 2016.
A Cell-Free Assembly System for Generating Infectious Human Papillomavirus 16 Capsids Implicates a Size Discrimination Mechanism for Preferential Viral Genome Packaging (2015)

Little is known about papillomavirus assembly biology due to the difficulties in propagating virus in vitro. The cell-free assembly method established in this paper reveals a new mechanism for viral genome packaging and will provide a tractable system for further dissecting papillomavirus assembly. The knowledge gained will increase our understanding of virus-host interactions, help to identify new targets for antiviral therapy, and allow for the development of new gene delivery systems based on in vitro-generated papillomavirus vectors.
Variation of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mi>c</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>with Electron-per-Atom Ratio in Superconducting Transition Metals and Their Alloys (1974)

A microscopic explanation is given for the variation of the superconducting transition temperature Tc with the electron-per-atom ratio in transition metals and their alloys.Received 17 June 1974DOI:https://doi.org/10.1103/PhysRevLett.33.1286©1974 American Physical Society
Area-efficient reed-solomon decoder design for optical communications (2009)

A high-speed low-complexity Reed-Solomon (RS) decoder architecture based on the recursive degree computationless modified Euclidean (rDCME) algorithm is presented in this brief. The proposed architecture has very low hardware complexity compared with the conventional modified Euclidean and degree computationless modified Euclidean (DCME) architectures, since it can reduce the degree computation circuitry and replace the conventional systolic architecture that uses many processing elements (PEs) with a recursive architecture using a single PE. A high-throughput data rate is also facilitated by employing a pipelining technique. The proposed rDCME architecture has been designed and implemented using SMIC 0.18-mum CMOS technology. Synthesized results show that the proposed RS (255, 239) decoder requires only about 18 K gates and can operate at 640 MHz to achieve a throughput of 5.1 Gb/s, which meets the requirement of modern high-speed optical communications.
Robust Matching in an Uncertain World (2010)

Finding point correspondences which are consistent with a geometric constraint is one of the cornerstones of many computer vision problems. This is a difficult task because of spurious measurements leading to ambiguously matched points and because of uncertainty in point location. In this article we address these problems and propose a new robust algorithm that explicitly takes account of location uncertainty. We propose applications to SIFT matching and 3D data fusion.
Introduction (2002)

The correspondence between Lu Xun (1881–1936), modern China's greatest writer, and Xu Guangping (1897–1968), his former student and his partner from 1927 to the end of his life, gives a unique insight into their private lives: how they felt about current events, about life in general, about themselves, and about each other. This book is about their intimate lives and their search for privacy as revealed in their published and unpublished letters. Part I relates the story of how Lu Xun and Xu Guangping became a couple. Part II begins with a general survey of letters, imagined letters, and love-letters in China and in the West. Part III examines the ‘personal space’ created by the deletions, recensions, retentions, and additions to Letters between Two in regard to its vocabulary, and relates it to the functions and values of privacy as defined in English-language studies.
Strategies for active and passive noise control (2000)

Noise control is a very crucial issue to be handled since the environmental concerns have become quite important. It involves careful diagnosis of the noise problem, prediction and design of various elements of the problem and application of best technology to solve the problem. Proper tools should be designed by the practicing engineers to curb the problem. Researchers should work to develop new technology. Noise will be effectively controlled once everyone contributes in this direction.
The use of histological techniques for the demonstration of ion exchange resins. (1999)

These staining results are consistent with the known structure and properties of polystyrene sulphonate and cholestyramine resins. Polystyrene sulphonate resins have the virtually pathognomonic feature of direct Schiff positivity, while morphology, location, and strong non-birefringent Congo red positivity facilitate the identification of cholestyramine. It is possible that the intrinsic staining characteristics of cholestyramine may be lost once it has bound to its target.
The Critical Role of LIGHT in Promoting Intestinal Inflammation and Crohn’s Disease (2005)

Crohn's disease (CD) is a type of inflammatory bowel disease associated with increased Th1 cytokines and unique pathological features. However, its pathogenesis has not been fully understood. Previous studies showed that homologous to lymphotoxin, exhibits inducible expression, competes with herpesvirus glycoprotein D for HVEM on T cells (LIGHT) transgenic (Tg) mice develop autoimmunity including intestinal inflammation with a variable time course. In this study, we establish an experimental model for CD by adoptive transfer of Tg mesenteric lymph node cells into RAG(-/-) mice. The recipients of Tg lymphocytes rapidly develop a disease strikingly similar to the key pathologic features and cytokine characterization observed in CD. We demonstrate that, as a costimulatory molecule, LIGHT preferentially drives Th1 responses. LIGHT-mediated intestinal disease is dependent on both of its identified signaling receptors, lymphotoxin beta receptor and herpes virus entry mediator, because LIGHT Tg mesenteric lymph node cells do not cause intestinal inflammation when transferred into the lymphotoxin beta receptor-deficient mice, and herpes virus entry mediator on donor T cells is required for the full development of disease. Furthermore, we demonstrated that up-regulation of LIGHT is associated with active CD. These data establish a new mouse model resembling CD and suggest that up-regulation of LIGHT may be an important mediator of CD pathogenesis.
Recombinant murine IL-3 fails to stimulate T or B lymphopoiesis in vivo, but enhances immune responses to T cell-dependent antigens. (1988)

We have explored the in vivo effect of IL-3 on the lymphopoiesis and humoral responses of mice bearing osmotic minipumps loaded with murine rIL-3 for 1 to 4 wk. A marked splenomegaly due to the accumulation of hemopoietic precursors was seen, but no increase was found in the lymphoid organs in the total number of cells belonging to the T or B lymphocyte lineage, i.e., of L3T4+ or Lyt-2+, or of allospecific cytotoxic T lymphocyte precursor for the T lineage, or of sIg+ or B220+ cells, or of B colony-forming cells for the B lineage; total activity of natural killer and lymphokine-activated killer cells was decreased. In contrast to the splenomegaly, a marked diminution in the number of thymocytes was observed, suggesting that rIL-3 in large amounts does suppress the T lymphopoiesis, perhaps as the result of the selective stimulation of early progenitor cells toward the hemopoietic pathway. rIL-3 perfusion during immunization increased the IgM and IgG responses to a T cell-dependent antigen, human IgG, and prevented tolerance induction by the deaggregated human IgG, although in the same conditions it did not modify the response to a T cell-independent antigen. Our results suggest that in vivo IL-3 does not act directly on lymphocytes or their precursors, but may potentiate the humoral immune response to T cell-dependent antigens, presumably by acting on accessory cells.
OBSERVATION OF FRACTURE SURFACES OF TRC TEST SPECIMENS WITH SCANNING ELECTRON MICROSCOPE (1974)

Delayed cracking sensitivity of some kinds of high strength steels was evaluated by the TRC test and the fracturre surfaces of specimens, which had root cracking, were observed by scanning electron microscope. The relation was investigated between the tensile restraint stress (=applied stress), the quasi-cleavage fracture area and rupture time.
A revolute joint with linear load-displacement response for precision deployable structures (1996)

NASA Langley Research center is developing key structures and mechanisms technologies for micron-accuracy, in-space deployment of future space instruments. Achieving micron-accuracy deployment requires significant advancements in deployment mechanism design such as the revolute joint presented herein. The joint presented herein exhibits a load-cycling response that is essentially linear with less than two percent hysteresis, and the joint rotates with less than one in.-oz. of resistance. A prototype reflector metering truss incorporating the joint exhibits only a few microns of kinematic error under repeated deployment and impulse loading. No other mechanically deployable structure found in literature has been demonstrated to be this kinematically accurate.