gebhart/patrepeval huggingface dataset:
Cell Cycle Genes in Ovarian Cancer (2004)

Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell cycle-regulatory mechanisms. The regulatory pathways controlling cell cycle phases include several oncogenes and tumor suppressor genes that display a range of abnormalities with potential usefulness as markers of evolution or treatment response in ovarian cancer. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary. We sought to divide cell cycle-regulatory genes into four subgroups on the basis of their predominant role in a specific phase or during the transition between two phases of the cell cycle.
Acutely decompensated heart failure: opportunities to improve care and outcomes in the emergency department. (2002)

Each year about 550,000 new patients are diagnosed as having congestive heart failure, which for acutely symptomatic patients is also referred to as acutely decompensated heart failure. The incidence of congestive heart failure is approximately 10 per 1000 for Americans over the age of 65 years. Men and women are affected in equal numbers, and 5-year mortality has been reported to be as high as 50%. Increased longevity increases the likelihood that heart failure will develop as a consequence of pathophysiologic processes that gradually weaken the myocardium and the vascular system. Patients who present to the emergency department with complaints of shortness of breath, dyspnea on exertion, increasing lower extremity edema, and/or worsening fatigue should have heart failure included in the differential diagnosis. Heart failure patients experiencing symptoms consistent with cardiac ischemia, hypoxia, potentially lethal arrhythmias, marked hypertension, or hypotension should be immediately triaged to a critical care area. The approval of nesiritide by the U.S. Food and Drug Administration in 2001 has stimulated the development of revisions in strategies for the emergency department treatment of acute decompensated heart failure patients. The early use of nesiritide, along with topical nitroglycerin and a loop diuretic, may lead to more rapid resolution of these patients' acute symptoms and hemodynamic dysfunction.
Pruritus and activity of pemphigus vulgaris (1992)

ABSTRACT: Appearance of pruritus was followed by relapse or aggravation of existing lesions in three histopathologically confirmed cases of pemphigus vulgaris. The conventional antithistaminics were not of much use in relieving the pruritus. The pruritus was controlled only when the pemphigus vulgaris was controlled by oral/parenteral steriod therapy.
Correction Factors for Mindlin Higher-order Plate Theory with the Consideration of Electrodes (2007)

Mindlin plate theory has been the choice for the analysis of high frequency vibrations of piezoelectric quartz crystal resonators, which utilize electroded crystal plates vibrating at the thickness-shear and overtone modes to achieve frequency generation functions and applications. For this purpose, Mindlin plate equations have been simplified, modified, and corrected to accommodate the actual geometry, structural complications, practical boundary conditions, and various bias fields such as temperature change and initial stresses. Accordingly, the correction of Mindlin plate theory should also include complications through factors which adjust the thickness-shear frequencies to the exact three-dimensional solutions from earlier studies with the first-order plate equations. In recent studies, correction factors for equations up to the third-order theory have been introduced and they have the capability to make the cut-off frequencies for the thickness-shear modes accurate up to much higher-orders and improving the accuracy of the extensional mode groups also. These correction factors are derived based on the general principle of comparison and matching of exact frequencies of interested vibration modes in the coupled two-dimensional equations, and the inclusion of structural complications such as electrodes is an natural extension of the derivation with practical importance. In this study, we consider the effect of thin electrodes through their mass loading formulation by adding the mass ratio in the inertia terms as demonstrated by Mindlin and others. Consequently, a set of frequency equations for both thickness-shear and extensional modes are established with the inclusion of mass ratio of electrodes. These equations are solved numerically for mass ratios to obtain the corresponding correction factors which have been modified by the presence of electrodes. These correction factors can be utilized in the improvement of applications of the higher-order plate equations with the finite element implementation, which remains as one of the reliable tool in the precise analysis and design of quartz crystal resonators. The derivation of these correction factors can be further incorporated into nonlinear equations of piezoelectric solids.
Factors Affecting the Cardiotoxic Potential of Cobalt (1969)

(1969). Factors Affecting the Cardiotoxic Potential of Cobalt. Clinical Toxicology: Vol. 2, No. 3, pp. 257-271.
A framework for unifying reordering transformations (1993)

We present a framework for unifying iteration reordering transformations such as loop interchange, loop distribution, skewing, tiling, index set splitting and statement reordering. The framework is based on the idea that a transformation can be represented as a schedule that maps the original iteration space to a new iteration space. The framework is designed to provide a uniform way to represent and reason about transformations. As part of the framework, we provide algorithms to assist in the building and use of schedules. In particular, we provide algorithms to test the legality of schedules, to align schedules and to generate optimized code for schedules. This work is supported by an NSF PYI grant CCR-9157384 and by a Packard Fellowship. 1 Introduction Optimizing compilers reorder iterations of statements to improve instruction scheduling, register use, and cache utilization, and to expose parallelism. Many different reordering transformations have been developed and studied, su...
Hydroacylation of Activated Ketones Catalyzed by <i>N</i>-Heterocyclic Carbenes (2006)

N-heterocyclic carbenes derived from triazolium salts are effective catalysts between 10 and 15 mol % for the hydroacylation of activated ketones. The reducing equivalent is generated via the interaction of a nucleophilic carbene species and an aromatic aldehyde. The subsequent alcohol product can undergo an acylation event with the resulting acyl heteroazolium intermediate formed in situ between the NHC and the aldehyde. This unprecedented multiple bond-forming reaction can accommodate aromatic aldehydes as the hydride source and various electron-deficient ketones. Preliminary mechanistic evidence indicates that the reduction and acylation steps are sequential operations. The intramolecular variant of this organocatalytic reaction affords benzofuranones in good yield.
Dispersion compensation of 16 ps pulses over 100km ofstep-index fibre using cascaded chirped fibre gratings (1995)

The propagation of 16 ps data pulses over 100 km of step-index fibre using two cascaded chirped fibre gratings to achieve dispersion compensation is presented. At the output, the pulses are broadened slightly to 20 ps, indicating the potential for 50 Gbit/s operation.
10-bit 100-MS/s Pipelined ADC Using Input-Swapped Opamp Sharing and Self-Calibrated V/I Converter (2010)

A 31 mW, 10-bit 100-MS/s pipelined analog-to-digital converter (ADC), which alleviates the memory effect occurring in the opamp-sharing technique, and automatically corrects the current error of the V/I converter, has been developed. The proposed ADC achieves low-power consumption, high noise immunity, and has a small area, by employing an input-swapped opamp-sharing technique that switches the summing node in an multiplying digital-to-analog converter and a V/I converter with a process, supply voltage, and temperature condition detector. The ADC shows a differential nonlinearity of less than 0.48 LSB, and an integral nonlinearity of less than 0.95 LSB. Also, an signal-to-noise-and-distortion ratio of 56.2 dB is measured with a 1 MHz input frequency. This has been implemented in a 0.18-μm CMOS process, and occupies 1.6 × 0.8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of active area.
Consumer Perception Towards Green Practice: An Empirical Study on Young Consumer from Bangladesh Perspective (2017)

The shift of consumer perception to green product is a great evolution in the recent year. Several changes are already appeared in consumer observation. Different variables are responsible for changing of consumer behavioral pattern. The two major revolutions in consumer market are awareness of environment friendly product or green product and switching to electronic store. This research empirically investigated the consumer awareness about environment friendly product from the perspective of Bangladeshi young consumers’ perception. The investigation shows that young consumers are more interested to green products than ever before. Young consumers are highly satisfied with the label green practices. This generation is more conscious about future, they believe that the environment will reply roughly on their unconsciousness to it, they aware about product recycles, they aware about the danger of high carbon emission in this planet. However, such awareness is also related with level of education of country citizen and their universal knowledge. Young enthusiasts from Bangladesh have frequent access in online and offline media and they are developing knowledge on different matters. Green practices are recognized by different elite and authorized bodies, so consumer perception is also changing depending on movement regarding green practices. This research examined the scenario of young consumer perception toward green movement. Data has been collected from young enthusiast and sample size is 200. This research indicates that consumer with high environmental concern are more interested to buy and use green products. Keyword s: Consumer Perception, Green Practices, Green Consumer, Green Marketing
Graphene formation mechanisms on<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mn>4</mml:mn><mml:mi>H</mml:mi><mml:mtext>-SiC</mml:mtext><mml:mrow><mml:mo>(</mml:mo><mml:mrow><mml:mn>0001</mml:mn></mml:mrow><mml:mo>)</mml:mo></mml:mrow></mml:mrow></mml:math> (2009)

Graphene is created through thermal decomposition of the Si face of $4H\text{-SiC}$ in high-vacuum. Growth temperature and time are varied independently to gain a better understanding of how surface features and morphology affect graphene formation. Growth mechanisms of graphene are studied by ex situ atomic force microscopy (AFM) and scanning tunneling microscopy (STM). On the route toward a continuous graphene film, various growth features, such as macroscale step bunching, terrace pits, and fingers, are found and analyzed. Topographic and phase AFM analysis demonstrates how surface morphology changes with experimental conditions. Step-bunched terraces and terrace pits show a strong preference for eroding along the ${11\overline{2}0}$ planes. Data from AFM are corroborated with STM to determine the surface structure of the growth features. It is shown that elevated finger structures are SiC while the depressed interdigitated areas between the fingers are comprised of at least a monolayer of graphene. Graphene formation at the bottom of terrace pits shows a dependence on pit depth. These features lend support for a stoichiometric view of graphene formation based on the number of decomposing SiC bilayers.
Motion detection silicon retina based on event correlations (2002)

This article reports on a functional two-dimensional analog silicon retina performing motion detection along three directions at 120 degrees of each other and 2 speed channels per direction. The output of each channel is binary, however integration of this information over time yields an analog value. Motion detection is performed by correlation of events, which are the disappearance of edges. A retina made of 23 by 23 pixels with an hexagonal layout of pixels was integrated in a 2 /spl mu/m CMOS technology and showed to perform well. Pixel size is 223 /spl mu/m/spl times/215 /spl mu/m and consumption is around 20 /spl mu/W per pixel.
Parallel control of the UPS inverters (2008)

This paper deals with the design of good quality output voltage waveform and excellent power sharing of uninterruptible power system (UPS) inverters with parallel-connection capability. In this sense, the controller is designed by using two nested loops: 1) the inner loop is performed by using the output voltage and inductor current double loop controller, providing a good static and dynamic response of a single UPS. 2) the outer loop calculates the output active and reactive powers and adjusts the output voltage amplitude and phase during the load transients. Integrated with the power control and the output filter current control, the proposed load-sharing control can improve the current-sharing quality and stability of the paralleled UPS system. In order to eliminate the high frequency circulation current around carrier wave frequency, the triangle carrier wave synchronization is used. Experimental studies using two parallel 30 KVA UPS’s are presented to show the effectiveness of the proposed control.
Synthesis of N-Substituted 3,5-Bis(arylidene)-4-piperidones with High Antitumor and Antioxidant Activity (2011)

A series of 3,5-bis(arylidene)-4-piperidone (DAP) compounds are considered as synthetic analogues of curcumin for anticancer properties. We performed structure-activity relationship studies by synthesizing a number of DAPs N-alkylated or acylated with nitroxides or their amine precursors as potent antioxidant moieties. Both subtituents on arylidene rings and on piperidone nitrogen (five- or six-membered, 2- or 3-substituted or 3,4-disubstituted isoindoline nitroxides) were varied. The anticancer efficacy of the new DAP compounds was tested by measuring their cytotoxicity to cancer cell lines A2780 and MCF-7 and to the H9c2 cell line. The results showed that all DAP compounds induced a significant loss of cell viability in the human cancer cell lines tested; however, only pyrroline appended nitroxides (5c (Selvendiran, K.; Tong, L.; Bratasz, A.; Kuppusamy, L. M.; Ahmed, S.; Ravi, Y.; Trigg, N. J.; Rivera, B. K.; Kálai, T.; Hideg, K.; Kuppusamy, P. Mol. Cancer Ther. 2010, 9, 1169-1179), 5e, 7, 9) showed limited toxicity toward noncancerous cell lines. Computer docking simulations support the biological activity tested. These results suggest that antioxidant-conjugated DAPs will be useful as a safe and effective anticancer agent for cancer therapy.
Recipe recognition with large multimodal food dataset (2015)

This paper deals with automatic systems for image recipe recognition. For this purpose, we compare and evaluate leading vision-based and text-based technologies on a new very large multimodal dataset (UPMC Food-101) containing about 100,000 recipes for a total of 101 food categories. Each item in this dataset is represented by one image plus textual information. We present deep experiments of recipe recognition on our dataset using visual, textual information and fusion. Additionally, we present experiments with text-based embedding technology to represent any food word in a semantical continuous space. We also compare our dataset features with a twin dataset provided by ETHZ university: we revisit their data collection protocols and carry out transfer learning schemes to highlight similarities and differences between both datasets. Finally, we propose a real application for daily users to identify recipes. This application is a web search engine that allows any mobile device to send a query image and retrieve the most relevant recipes in our dataset.
The Initiation of Electrical Breakdown in Vacuum—A Review (1973)

Recent investigations are reviewed of prebreakdown conduction phenomena in vacuum both for steady and for step-function applied voltages. The results of these investigations have led to the formulation of models to explain the initiation of the vacuum discharge by ionization of a vapor medium, the vapor being composed of atoms of one or both of the electrodes. A detailed examination of the events leading to breakdown has allowed a more critical evaluation of the merits and deficiencies of the various breakdown models.
Effect of menthol derivatives on skin permeation of oxybutynin. (1997)

Oxybutynin (OB) is widely used for the treatment of incontinence due to neurogenic bladder dysfunction. In order to reduce side effects and increase therapeutic efficiency, we investigated transdermal therapeutic system of OB. in vitro skin permeation study was performed by employing the vertical diffusion cell in which the excised rat abdominal skin was mounted, and menthol derivatives were selected as effective enhancers. The flux of OB was remarkably increased by the addition of several kind of menthol derivatives (e.g. O-ethylether (MET), O-allylether, O-2-propynylether, O-methylester, O-propylester, O-isopropylester, and O-cyclopropylester). Among these compounds, the skin irritancy of MET was significantly low compared with the other compounds. Therefore, MET is thought to be a promising compound as effective absorption enhancer for the transdermal drug delivery of OB. The data obtained from in vitro skin permeation study were analyzed by a membrane diffusion model derived from Fick's second law, and the diffusion and partition parameters of OB were estimated. The diffusion parameters were increased when the menthol derivatives were incorporated in hydrogel. On the other hand, partition parameters were almost constant. The flux of OB increased with increase of the concentration of MET. Maximum flux was observed when the hydrogel containing 0.5% MET was applied. No further increase of flux was obtained when the amount of MET was increased. In in vivo percutaneous absorption, the excretion of urine was restrained until 8h by the administration of OB hydrogel containing 0.5% MET. It was suggested that OB was delivered through the skin from hydrogel containing 0.5% MET. In conclusion, it was suggested that OB hydrogels containing menthol derivatives, especially MET, were available as a new dosage form for the treatment of incontinence due to neurogenic bladder dysfunction.
Synthesis of pyridine derivatives of L-phenylalanine as antisickling reagents (1984)

Several bicyclic agents composed of L-phenylalanine coupled to various pyridines were synthesized: 2-, 3-, and 4-(L- phenylalanylamino )pyridine. All three compounds at 3 mM gave positive morphological antisickling effects on homozygous SS cells under reduced O2 tension. Studies on two of these compounds, 2- and 3-(L- phenylalanylamino )pyridine, showed that these agents increase the deoxy-HbS solubility ratio, Cs/ Cs0 , by 14% at 20 mM. Observed changes in the mean corpuscular hemoglobin concentration (MCHC) values of treated cells ranged from 4% at 1.3 mM to 15% at 5.6 mM in compound concentration. Very minor lytic activity was found for treated cells, indicating water uptake is responsible for changes in the MCHC. Further, exposure of sickle cells to a 3 mM concentration of these agents also increased by 6- to 7-fold cellular deformability of a treated erythrocyte population as compared to an untreated one at the same total O2 saturation of 47%. These agents demonstrate the potential of bicyclic compounds composed of a common constituent, L-Phe, in the development toward a viable therapeutic agent.
A comparative study of cell classifiers for image-based high-throughput screening (2014)

Our study proposes SVM (linear) for iterative improvement of the training data and SVM (RBF) for the final classifier to classify all unlabeled cells in the whole data set.
Research of Submarine Hovering based on Fuzzy Control (2015)

The underwater hovering of submarine is to keep and alter depth at zero speed, which is a complex nonlinear process. Traditional control methods affect the effect because of lacking of adaptive capability, while fuzzy control can solve the problem well. Here the structure of fuzzy controller was set up based on the principle of fuzzy control. Then the rule for hovering control was carried out according to the classic step response. At last, the anti-jamming differentiator was set up by Simulink. The result of two basic working condition simulation showed that fuzzy controller was able to fix the submarine depth well, and had the advantage of fast and robust.
Effect of cholecystokinin octapeptide antagonists on the extinction of an active avoidance task in the rat (1989)

Abstract Cholecystokinin octapeptide (CCK‐8) has been shown to be involved in memory processes. For example, in the absence of endogenous CCK‐8 in the brain, memory processes are imparied. In order to extend the understanding of this relationship, the present study observed the effect of novel potent CCK‐8 antagonists, L‐364,718 and CR 1409, on active avoidance responding in the rat. These antagonists caused marked impairment in the performance of the learned task when administered intracerebroventricularly immediately after the learning trials. The results suggest that CCK‐8 is indispensable for memory processes.
Purification and characterization of heparin-binding growth factors from porcine uterus (1990)

Heparin-binding growth factors present in pig uterine tissue were purified by approx. 50,000-fold using a combination of ammonium sulphate precipitation, ion-exchange chromatography and heparin-affinity chromatography. Purification of the uterus-derived growth factors (UDGFs) was monitored by the stimulation of [3H]thymidine incorporation into Swiss 3T3 cells and by a radioreceptor assay using 125I-labelled epidermal growth factor (EGF) as the ligand. The latter was shown to be a novel, rapid and reliable assay for heparin-binding growth factors which utilizes their trans-modulation of EGF receptor affinity. UDGFs exhibit strong affinity for immobilized heparin and two forms, named alpha UDGF and beta UDGF, were distinguished by salt gradient elution from heparin-agarose affinity columns. beta UDGF activity was eluted from heparin-agarose between 1.5 M- and 1.8 M-NaCl, and was correlated with the elution of a protein doublet of 17.2 kDa and 17.7 kDa. Immunoblotting of heparin-purified beta UDGF indicated that the beta UDGF doublet is immunologically related to the 146-amino-acid form of bovine basic fibroblast growth factor (bFGF), and that the 17.2 kDa component is an N-terminally truncated form of the 17.7 kDa component. After purification by C4 reversed-phase h.p.l.c., this doublet was biologically active and greater than 95% pure as assessed by silver-stained SDS/PAGE. Amino acid composition and sequence analysis confirmed that these beta UDGF polypeptides were microheterogeneous forms of bFGF. Fractions containing alpha UDGF activity were eluted from heparin-agarose in 1.3 M-NaCl. These fractions contained a 16.5 kDa protein which co-migrated on SDS/polyacrylamide gels with recombinant human acidic FGF (aFGF) and which which cross-reacted with an antiserum raised against aFGF. The identification of heparin-binding growth factors in porcine uterus at the time of implantation raises the possibility that they function in the reproductive tract during early pregnancy.