gebhart/patrepeval huggingface dataset:
Optimization of the ratio of stannous tin: ethane-1-hydroxy-1, 1-diphosphonate for bone scanning with 99mTc-pertechnetate. (1974)

BS>Using synthetic hydroxyapatite (HA) as an in vitro skeletal model, the optimum formulation of a /sup 99m/Tc-distannous ethane1-hydroxy-1, 1- diphosphonate (/sup 99m/Tc --Sn - EHDP) bone scanning agent was determined by measurement of the amount of radiotagged components (/sup 99m/Tc, /sup 113/Sn, and 1-/sup 14/C --EHDP) on HA. A range of EHDP to stannous chloride weight ratios (5: 1 to 50: 1) was found to yield complete (>95%) sorption on HA of the / sup 99m/Tc-Sn -EHDP bone scanning agent. Using the 12: 1 and 50: 1 ratios, organ distribution and blood clearance for 1-/sup 14/C--EHDP, /sup 113/Sn, and /sup 99m/ Tc were determined in Sprague --Dawley rats. Major whole organs, selected skeletal samples, urine, and feces were assayed by liquid scintillation and gamma spectrometers. The /sup 99m/Tc--Sn EHDP agent was found to be nearly evenly distributed between the skeleton and urine with less than 2% of the dose in soft tissue. The /sup 99m/Tc --Sn - EHDP agent yielded excellent scintiscans of the skeletal system. The rapid blood clearance is comparable to /sup 18/F, and the physical and chemical properties of the diphosphonate agent suggest an advantage over the /sup 99m/Tc-labeled polyphosphate or pyrophosphate bone scanning agents. (auth)
Energy-efficient heterogeneous reconfigurable sensor node for distributed structural health monitoring (2012)

Distributed structural health monitoring (SHM) using wireless sensor nodes (WSN) requires frugal spending of the limited energy budget. We propose a reconfigurable heterogeneous architecture, combining a low-power micro-controller (MCU) with a Field-Programmable Gate Array (FPGA), as a means for energy-efficient in-sensor processing. Details covered include a generic communication interface between both computing units and several clock-management schemes for energy efficiency. We evaluate the architecture on the usecase of a Random Decrement (RD) algorithm and also consider additional pre-filtering to reduce the volume of wirelessly transmitted data. Compared to conventional low-power sensor nodes, we can reduce the energy required for data processing by up to 81 %. Index Terms — wireless sensor network, reconfigurable computing, structural health monitoring, energy efficiency, random decrement technique 1.
Long-Period Fiber Gratings for Mode Coupling in Mode-Division-Multiplexing Systems (2015)

In mode-division-multiplexing systems, multi-input multi-output (MIMO) equalization is used to compensate for linear impairments, including modal dispersion (MD) and modal crosstalk. The MIMO equalizer memory length depends on the group delay (GD) spread arising from MD. The GD spread arising from MD can be significantly reduced by introducing strong mode coupling via mode scramblers. We study the design of such mode scramblers implemented as long-period multimode fiber gratings for systems using D = 12 modes (six spatial modes). By optimizing the grating chirp function, we minimize the mode-dependent loss (MDL) of the grating while ensuring full intergroup mode coupling. We find a design yielding MDL and mode-averaged loss in the C band not exceeding 0.36 and 0.45 dB, respectively. We also verify the effect of such mode scramblers on the GD scaling of a long-haul system, demonstrating that the scramblers reduce the scaling of GD spread with length from a linear to a square-root dependence, as expected in the strong coupling regime.
Activated dendritic cells delivered in tissue compatible biomatrices induce <i>in-situ</i> anti-tumor CTL responses leading to tumor regression (2016)

Dendritic cell (DC) based anti-cancer immunotherapy is well tolerated in patients with advanced cancers. However, the clinical responses seen after adoptive DC therapy have been suboptimal. Several factors including scarce DC numbers in tumors and immunosuppressive tumor microenvironments contribute to the inefficacy of DCs as cellular vaccines. Hence DC based vaccines can benefit from novel methods of cell delivery that would prevent the direct exposure of immune cells to suppressive tumor microenvironments. Here we evaluated the ability of DCs harbored in biocompatible scaffolds (referred to as biomatrix entrapped DCs; beDCs) in activating specific anti-tumor immune responses against primary and post-surgery secondary tumors. Using a preclinical cervical cancer and a melanoma model in mice, we show that single treatment of primary and post-surgery secondary tumors using beDCs resulted in significant tumor growth retardation while multiple inoculations were required to achieve a significant anti-tumor effect when DCs were given in free form. Additionally, we found that, compared to the tumor specific E6/E7 peptide vaccine, total tumor lysate induced higher expression of CD80 and CD40 on DCs that induced increased levels of IFNγ production upon interaction with host lymphocytes. Remarkably, a strong immunocyte infiltration into the host-implanted DC-scaffold was observed. Importantly, the host-implanted beDCs induced the anti-tumor immune responses in the absence of any stromal cell support, and the biomatrix structure was eventually absorbed into the surrounding host tissue. Collectively, these data indicate that the scaffold-based DC delivery may provide an efficient and safe way of delivering cell-based vaccines for treatment of primary and post-surgery secondary tumors.
Removal of Selenate by Fe and NiFe Nanosized Particles (2004)

Irrigation drainage and industrial wastewaters often contain elevated levels of toxic anions such as selenate, arsenate, and chromate. Immobilizing the contaminants via reaction with zero-valent iron has been proven to be an effective remediation method. Ultrafine metallic and bimetallic particles were prepared by borohydride reduction of aqueous salt solutions and characterized. Nanosized zero-valent NiFe and iron particles rapidly reduced and immobilized selenate from aqueous solutions. Nearly 100% selenate removal was obtained in 5 h. The data show that, at identical solids concentrations, the use of NiFe particles accomplished 42 and 56% greater removals, respectively, than the use of Fe and Ni particles individually. At low selenate concentrations, the selenium removal rate followed the first-order rate kinetics that shifted to zeroth-order at higher concentrations. The maximum selenate removal (87% in 30 min at a solids concentration of 0.5 g/L) was obtained by bimetallic particles containing 70 at. % iron. High removal capacities were observed at pH lower than 8. A mechanism for the selenate removal has been developed.
Detection of HIV-1 proviral DNA in sperm from HIV-1-infected men (1994)

HIV-1 proviral DNA can be demonstrated by IS-PCR in seminal mononuclear cells and sperm from certain HIV-1-infected men. The role played by proviral DNA in these cells in the sexual transmission of this retroviral agent will require further study.
A model of intrinsic sphincteric deficiency in the rat: Electrocauterization (2004)

Cauterization of tissues lateral to the mid-urethra decreased LPP without affecting bladder function. This electrocauterization model produced low LPPs that, after 2 weeks, were maintained for up to 16 weeks. Histology suggests that damage to striated muscle and nerves might have contributed to the change in LPP in this model for ISD.
Optical measurement of deformation using transparent silica gel to model sand (2002)

This paper addresses an important and critical need in geotechnical engineering. There are no established methods to measure three-dimensional deformation patterns and flow characteristics within a soil mass. As a result, it is difficult to analyze complex soil-structure interaction and ground flow problems. Measurement of three-dimensional deformation patterns and flow characteristics within a soil continuum are usually limited by the fact that soil sensors do not provide a continuous image of the measured continuum. Additionally, soil sensors exhibit static and dynamic characteristics that are different from those of the surrounding soils, and therefore can change the response of the measured continuum. The fundamental premise of this research is that tests conducted with a transparent material with geotechnical properties similar to those of natural soils can circumvent these experimental problems if the response of a model transparent continuum can be measured using non-intrusive optical visualization techniques. This paper presents the geotechnical properties of a new family of transparent materials made of silica gels, which are suitable for modeling the geotechnical properties of sand. A new imaging technique that makes uses of the developed material in measuring spatial deformations in transparent soil models is also presented.
Direct diode-laser pumping of a mode-locked Ti:sapphire laser (2011)

Direct diode-laser pumping of a mode-locked Ti:Al(2)O(3) laser is reported. A single 1 W GaN-based diode laser operating at 452 nm is used as the pump laser. Pulse durations as short as 114 fs and average output powers of up to 13 mW are obtained.
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin (2015)

MicroRNAs regulate gene expression posttranscriptionally and function within the cells in which they are transcribed. However, recent evidence suggests that microRNAs can be transferred between cells and mediate target gene repression. We find that endogenous miR-155 and miR-146a, two critical microRNAs that regulate inflammation, are released from dendritic cells within exosomes and are subsequently taken up by recipient dendritic cells. Following uptake, exogenous microRNAs mediate target gene repression and can reprogramme the cellular response to endotoxin, where exosome-delivered miR-155 enhances while miR-146a reduces inflammatory gene expression. We also find that miR-155 and miR-146a are present in exosomes and pass between immune cells in vivo, as well as demonstrate that exosomal miR-146a inhibits while miR-155 promotes endotoxin-induced inflammation in mice. Together, our findings provide strong evidence that endogenous microRNAs undergo a functional transfer between immune cells and constitute a mechanism of regulating the inflammatory response.
Coordinated reactive compensation in a Wind Park (2007)

In wind energy, an incentive payment related to the reactive power compensation is applied. In the past, the maximum incentive was achieved when the cos phi, that was calculated as a monthly mean, was almost unitary (cos phi = 1.00). The payment is a percentage of the average reference tariff (ART). Since the 1st of January 2007, the Spanish regulation RD 436 /2004 has modified the incentive payment. Nowadays, it is calculated each 15 minutes from the energy during this period, and its maximum value depends on the achievement of a objective power factor (cos phi) which is defined in three time frames: peak hours (cos phi < 0,95 cap.), valley hours (cos phi < 0.95 ind.) and flat hours (cos phi = 1.00). To maximize the incentive payment, in the Sotavento Experimental Wind Park (Spain) a configuration with a central controller that coordinates the actuation over all the capacitor steps in the wind park has been installed. In this article, a central controller algorithm which is based on a dynamic programming is proposed. Its main objectives are: to maximize the incentive payment, or achieve the equivalent objective PF, and to minimize the number of connection operations over the capacitor steps (especially those in substation). At the present time, the algorithm is being tested in the wind park.
A Reachability Query Approach with Path Interval Labeling (2014)

For a directed graph and two vertices, to check whether there is a path between them is so-called reach ability query, how to establish efficient index to answer the reach ability of two nodes has always been a research direction in the field of database. In this paper, we proposed a reachability query approach combining the concept of path dividing and interval labeling. We establish an index with path interval labeling, also two kinds of query strategies are presented. And experimental results on real data sets show that with a path interval labeling it has a better time efficiency of querying.
Antibody-drug conjugates for non-oncological indications (2016)

By definition, antibody–drug conjugates (ADCs) use monoclonal antibodies to selectively deliver potent cytotoxic agent to antigen-expressing tumor cells with reduced off-target toxicity, which has ...
Integrating an object server with other worlds (1987)

Object-oriented database servers are beginning to appear on the commercial market in response to a demand by application developers for increased modeling power in database systems. Before these new servers can enhance the productivity of application designers, systems designers must provide simple interfaces to them from both procedural and object-oriented languages. This paper first describes a successful interface between an object server and two procedural languages (C and Pascal). Because C and Pascal do not support the object-oriented paradigm application, designers using these languages must deal with database objects in less than natural ways. Fortunately, workstations supporting object-oriented languages have the potential for interacting with database objects in a much more integrated manner. To integrate these object-oriented workstations with an object server, we provide a design framework based on the notion of workstation agent objects representing principal objects in the database. We distinguish two types of agents: proxies , which forward most messages to the principal objects, and deputies , which can cache state for their principal and act with more autonomy. The interaction of cache, transaction, and message management strategies makes the implementation of deputies a nontrivial problem. The agent metaphor is being used currently to integrate an object server with a Smalltalk-8O™ workstation.
Highly Efficient Organic Sensitizers for Solid-State Dye-Sensitized Solar Cells (2009)

Organic sensitizers comprising of donor, electron-conducting, and anchoring groups are designed and developed for dye-sensitized solar cell applications. A solar cell employing 3-(5′-{4-[bis-(4-hexyloxy-phenyl)-amino]-phenyl}-[2,2′]bithiophenyl-5-yl)-2-cyano-acrylic acid dye spiro-OMeTAD as a hole-transporting material exhibits a short circuit photocurrent density of 9.64 mA/cm2, an open-circuit voltage of 798 mV, and a fill factor of 0.57, corresponding to an overall conversion efficiency of 4.4% at standard AM 1.5 sunlight. Photoinduced absorption spectroscopy probes an efficient hole-transfer from dyes to the spiro-OMeTAD.
Intrinsic reduction of the depolarization loss in solid-state lasers by use of a (110)-cut Y3Al5O12 crystal (2002)

The depolarization caused by thermally induced birefringence in Y3Al5O12 lasers is intrinsically reduced without any compensation by use of rods cut in other directions than (111). Using a (110)-cut crystal, one can expect the depolarization to become less than 1/10 of that caused in a conventional (111)-cut crystal.
Developing a scale to measure nurses' difficulty related to the treatment of gender dysphoric patients (2022)

This study aimed to develop a scale to measure the perceived difficulty experienced by nurses in treating and caring for patients diagnosed with gender dysphoria and examine its reliability and validity. We developed a 26-item preliminary scale through discussions with experts in gender dysphoria treatment. We administered a questionnaire including this scale to 1,010 nurses working at Okayama University Hospital and analyzed the data of 346 nurses who had been involved in the treatment of gender dysphoria and had no missing responses. A total of 20 items consisting of two factors, “relationship building” and “negative emotion for gender dysphoria,” were extracted by exploratory factor analysis, and we used them in the final version of the scale. Cronbach's alpha coefficient for the entire scale was 0.879, indicating a high degree of internal consistency. However, the correlations with a communication skills scale (ENDCOREs) and the Scale of Gender Conception were limited, and the external validity could not be proven. This scale may be useful for evaluating nursing practice and educational support for nurses; however, there is room for further study on the scale validation.
Structural and immunological relationships of isoferritins in normal and malignant cells. (1976)

Ferritins from normal adult human liver and heart were compared with ferritins from a lung carcinoma metastatic to liver and from HeLa cells on the basis of their isoferritin profiles, subunit composition, and immunological relationships. Each ferritin preparation gave different isoferritin profiles, but several contained common isoferritins. All of the tumor isoferritins had counterparts in the normal tissues. All ferritins contained similar subunits but in different proportions. Qualitative differences were demonstrable in some ferritins with antibodies to different tissue ferritins. These differences correlated with the subunit composition of the ferritins. By appropriate absorption, an antibody population was obtained that was apparently specific for one subunit type. Heart ferritin gave lines of apparent identity with the tumor ferritins with these antibodies. It is concluded that tumor ferritins are not tumor-specific antigens but correspond to isoferritins in normal adult heart.
Gravitational waves from rotating and precessing rigid bodies: Simple models and applications to pulsars (1979)

An axially symmetric, torque-free rigid body, rotating and precessing, emits gravitational quadrupole radiation at two frequencies, $\ensuremath{\omega}$ and $2\ensuremath{\omega}$, corresponding to the $l=2$, $m=1,2$ spherical harmonics. We present explicitly the waveforms of the two polarizations at both frequencies. From observations of gravitational waves, one can derive information about the body's orientation and its precession amplitude. Electromagnetic radiation emitted by a spot fixed on the surface of the body arrives in pulses at a mean frequency $\ensuremath{\Omega}$ which is typically different from $\ensuremath{\omega}$. If the body is not axially symmetric but the amplitude of the precession is small, the gravitational radiation at the lower frequency $\ensuremath{\omega}$ is split into two frequencies on either side of the electromagnetic pulse frequency. We present explicit waveforms for the two polarizations in this case also.
Proteinase-Activated Receptor-2-Induced Colonic Inflammation in Mice: Possible Involvement of Afferent Neurons, Nitric Oxide, and Paracellular Permeability (2003)

Activation of colonic proteinase-activated receptor-2 (PAR-2) provokes colonic inflammation and increases mucosal permeability in mice. The mechanism of inflammation is under debate and could be neurogenic and/or the consequence of tight-junction opening with passage of exogenous pathogens into the lamina propria. The present study aimed to further characterize the inflammatory effect of PAR-2 activation by investigating: 1) the role of NO, 2) the role of afferent neurons, and 3) a possible cause and effect relationship between colonic paracellular permeability changes and mucosal inflammation. Thus, intracolonic infusion to mice of the PAR-2-activating peptide, SLIGRL, increased both myeloperoxidase (MPO) activity and damage scores indicating colonic inflammation, and enhanced colonic permeability to (51)Cr-EDTA from 2 to 4 h after its infusion. NO synthase inhibitors, L-NAME and aminoguanidine, as well as the neurotoxin capsaicin and NK1, calcitonin gene-related peptide (CGRP) receptor antagonists, SR140333 and CGRP(8-37), prevented SLIGRL-induced MPO and damage score increases and permeability. In contrast, although the tight-junction blocker, 2,4,6-triaminopyrimidine, and the myosin L chain kinase inhibitor, ML-7, prevented SLIGRL-induced increase in permeability, they did not prevent MPO and damage score increases. Taken together our data show that both NO and capsaicin-sensitive afferent neurons are involved in PAR-2-mediated colonic inflammation and paracellular permeability increase. Nevertheless, the inflammation process is not a consequence of increased permeability which results at least in part from the activation of myosin L chain kinase.
Automatic Star-Trackers for Long-Range Navigation (1965)

This paper describes development trends of one particular navigational technique (automatic star tracking) and its associated instrumentation methods one of which, the application of pulse code modulation theory to sensor design, is discussed in detail. Plans for the future development of this most promising concept are also included and the effects of military research and development efforts on civilian aircraft requirements are indicated. An appendix provides a glossary of special terms used. Automatic star-tracking systems have been used in military aircraft navigation for position fixing and heading correction for a number of years and the development of the equipment has been actively pursued by the U.S.A.F. since as early as 1946. Basically, star trackers are automatic devices that probe a portion of the celestial sphere for the purpose of detecting, acquiring and tracking stars or other celestial bodies. In using astronomical inputs for cruise vehicle navigation, advantage is taken of the well-known principle that sights on two or more stars when referred to the true vertical and time can be used to provide a position fix. It is the intent of this paper to review techniques used to instrument star trackers, discuss their application to long-range aircraft navigation, indicate development trends and introduce a new concept of employing pulse code modulation theory to the design of a simple, low cost automatic astro-tracker.
Rapid full-field OCT assessment of clinical tissue specimens(Conference Presentation) (2016)

FFOCT (Full Field Optical Coherence Tomography) is a novel optical technology that gives access to very high resolution tomography images of biological tissues within minutes, non-invasively. This makes it an attractive tool to bridge the gap between medical imaging modalities (MRI, ultrasound, CT) used for cancer lesion identification or targeting and histological diagnosis. Clinical tissue specimens, such as surgical cancer margins or biopsies, can potentially be assessed rapidly, by the clinician, in the aim to help him decide on the course of action. A fast FFOCT prototype was built, that provides 1cm2 images with 1 µm resolution in 1 minute, and can accommodate samples up to 50mm diameter. Specific work was carried out to implement a large sample holder, high-speed image acquisition system, optimized scanning, and accelerated GPU tiles stitching. Results obtained on breast, urology, and digestive tissues show the efficiency of the technique for the detection of cancer on clinical tissue specimens, and reinforce the clinical relevance of the technique. The technical and clinical results show that the fast FFOCT system can successfully be used for a fast assessment of cancer excision margins or biopsies providing a very valuable tool in the clinical environment.
<title>Statistical analysis of human body temperature asymmetry as the basis for detecting pathologies by means of IR thermography</title> (2001)

The left-right thermal asymmetry of human bodies is statistically analyzed on a few selected body parts. The three statistical parameters, including signal-to-noise ratio, Z-criterion and D-criterion, are recommended to verify a grade of asymmetry in the case of pathologies. The variability of these parameters attributed to healthy persons is discussed.
Lipopolysaccharide and Tumor Necrosis Factor Stimulate Lung Microvascular Arginine Uptake, a Response Attenuated by Dexamethasone (1996)

These data indicate that LPS and TNF additively stimulate arginine transport in lung microvascular endothelial cells via a pathway that requires de novo protein synthesis (possibly of the transporter protein itself) and that this response is attenuated by DEX.