gebhart/patrepeval huggingface dataset:
Evolution of Leptin Structure and Function (2011)

Leptin, the protein product of the obese(ob or Lep) gene, is a hormone synthesized by adipocytes that signals available energy reserves to the brain, and thereby influences development, growth, metabolism and reproduction. In mammals, leptin functions as an adiposity signal: circulating leptin fluctuates in proportion to fat mass, and it acts on the hypothalamus to suppress food intake. Orthologs of mammalian Lep genes were recently isolated from several fish and two amphibian species, and here we report the identification of two Lep genes in a reptile, the lizard Anolis carolinensis. While vertebrate leptins show large divergence in their primary amino acid sequence, they form similar tertiary structures, and may have similar potencies when tested in vitro on heterologous leptin receptors (LepRs). Leptin binds to LepRs on the plasma membrane, activating several intracellular signaling pathways. Vertebrate LepRs signal via the Janus kinase (Jak) and signal transducer and activator of transcription (STAT) pathway. Three tyrosine residues located within the LepR cytoplasmic domain are phosphorylated by Jak2 and are required for activation of SH2-containing tyrosine phosphatase-2, STAT5 and STAT3 signaling. These tyrosines are conserved from fishes to mammals, demonstrating their critical role in signaling by the LepR. Leptin is anorexigenic in representatives of all vertebrate classes, suggesting that its role in energy balance is ancient and has been evolutionarily conserved. In addition to its integral role as a regulator of appetite and energy balance, leptin exerts pleiotropic actions in development, physiology and behavior.
Import of proteins into chloroplasts (1990)

ABSTRACT Chloroplasts are the sites of photosynthesis in eukaryotic plants and are able to harvest solar energy for the synthesis of carbon skeletons. They, like mitochondria, are enclosed by two membranes; the outer and the inner envelope. The latter is the actual permeability barrier between the cytosol and the chloroplast stroma and the site of different metabolite translocators that coordinate the metabolism between compartments (Heldt and Flügge, 1987). Distinct from the envelope membranes are the energy-transducing thylakoid membranes that are located within the chloroplasts, and which enclose the thylakoid lumen. Stroma and thylakoid proteins each account for about 50% of the total chloroplast protein, whereas the two envelope membranes represent less than 1%. In spite of the chloroplasts’ semi-autonomy the majority of the chloroplasts proteins and also those of other cell compartments are coded for in the nucleus. These nuclear-coded proteins are synthesized in the cytosol, normally with N-terminal extensions called transit peptides, and are subsequently transported into the chloroplasts where they are processed to their mature sizes by specific proteases. Mechanisms must therefore exist to ensure that these proteins are (1) correctly targeted to chloroplasts and (2) subsequently localized into the correct chloroplast compartment: namely, the outer or inner envelope membrane, the intermembrane space, the chloroplast stroma, the thylakoid membrane or the thylakoid lumen. Major aspects of protein transport have been reviewed quite recently (Schmidt and Mishkind, 1986; Lubben et al. 1988; Keegstra et al. 1989). This Commentary will focus on the basic phenomena of this topic and will also present recent findings that extend the view of the reviews cited above.
Multi-Mode, Multi-Band Active-RC Filterand Tuning Circuits for SDR Applications (2010)

The CMOS multi-mode, multi-band low-pass filter and complex baseband filter are presented. Capacitors and resistors were shared to minimize the area. Proposed two-step tuning method can reduce the number of switches and thus, can reduce the noise and the area.
Emission properties of Ag/dielectric/Ag plasmonic thermal emitter with different lattice type, hole shape, and dielectric material (2009)

The emission spectra of the trilayer Ag/dielectric/Ag plasmonic thermal emitter (PTE) with different lattice type, hole shape, and dielectric material were investigated. It is found that the position and number of thermal emission peak of the PTE are determined by the lattice type not by the hole shape and dielectric materials. The PTE with hexagonal lattice generates only one strong (1,0) Ag/dielectric emission peak, whereas a similar PTE with square lattice generates two strong (1,0) and (1,1) Ag/dielectric emission peaks, their relative intensities follow the blackbody radiation law. This phenomenon suggests the coupling of Ag/dielectric and Ag/air modes.
Effects of post-deposition anneal on the electrical properties of Si<sub>3</sub>N<sub>4</sub> gate dielectric (2002)

The effects of postdeposition anneal of chemical vapor deposited silicon nitride are studied. The Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> films were in situ annealed in either H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> (2%)/O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> at 950/spl deg/C or N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O at 950/spl deg/C in a rapid thermal oxidation system. It is found that an interfacial oxide was grown at the Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> /Si interface by both postdeposition anneal conditions. This was confirmed by thickness measurement and X-ray photoelectronic spectroscopy (XPS) analysis. The devices with H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> (2%)/O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> anneal exhibit a lower gate leakage current and improved reliability compared to that of N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O anneal. This improvement is attributed to a greater efficiency of generating atomic oxygen in the presence of a small amount of hydrogen, leading to the elimination of structural defects in the as-deposited Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> film by the atomic oxygen. Good drivability is also demonstrated on a 0.12 μm n-MOSFET device.
Thalidomide Prevents Bleomycin-Induced Pulmonary Fibrosis in Mice (2007)

Pulmonary fibrosis in humans can occur as a result of a large number of conditions. In idiopathic pulmonary fibrosis (IPF), pulmonary function becomes progressively compromised resulting in a high mortality rate. Currently there are no proven effective treatments for IPF. We have recently reported that IL-6 and TGF-beta(1) plays an important role in proliferation and differentiation of lung fibroblasts, and all-trans-retinoic acid (ATRA) prevented bleomycin-induced lung fibrosis through the inhibition of these cytokines. Thalidomide (Thal) has been used in the treatment of multiple myeloma through the inhibitory effect on IL-6-dependent cell growth and angiogenesis. In this study, we examined the preventive effect of Thal on bleomycin-induced pulmonary fibrosis in mice. We performed histological examinations and quantitative measurements of IL-6, TGF-beta(1), collagen type Ialpha1 (COL1A1), vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) in bleomycin-treated mouse lung tissues with or without the administration of Thal. Thal histologically ameliorated bleomycin-induced fibrosis in mouse lung tissues. Thal decreased the expressions of IL-6, TGF-beta(1), VEGF, Ang-1 Ang-2, and COL1A1 mRNA in mouse lung tissues. In addition, Thal inhibited angiogenesis in the lung. In vitro studies disclosed that Thal reduced 1) production of IL-6, TGF-beta(1), VEGF, Ang-1, and collagen synthesis from human lung fibroblasts, and 2) both IL-6-dependent proliferation and TGF-beta(1)-dependent transdifferentiation of the cells, which could be the mechanism underlying the preventive effect of Thal on pulmonary fibrosis. These data may provide a rationale to explore clinical use of Thal for the prevention of pulmonary fibrosis.
Heart size and function after radiation therapy to the mediastinum in patients with Hodgkin's disease. (1983)

Changes in the transverse heart diameter and cardiothoracic ratio were determined by comparing the pretreatment and last follow-up posteroanterior chest x-rays of 96 patients with stage I-III Hodgkin's disease who had received radiation therapy (RT) to the mediastinum, with the same parameters observed in 20 similar patients whose mediastinum was not irradiated. A significantly higher proportion of patients who had received RT to the mediastinum had a decrease in transverse heart diameter and cardiothoracic ratio. Among patients presenting with a large mediastinal mass, these changes were more pronounced as compared to the other groups; however, this difference was not of statistical significance. First-pass left ventricular ejection fraction (LVEF) performed with 99mTc pertechnetate (obtained in 55 of these patients 30-120 months after RT to the mediastinum) was compared with the LVEF of 20 normal controls. The control group had a significantly higher LVEF than the group of patients who had received RT to the mediastinum. No correlation was observed between changes in these parameters and the use of adjuvant, salvage, or no chemotherapy after mediastinal RT. None of these patients presented congestive heart failure or constrictive pericarditis, but our findings indicate a subclinical cardiomyopathy in more than one-half of the patients who received RT to the mediastinum, suggesting that the incidence of heart damage after mediastinal RT might be higher than expected. Prospective studies are necessary to elucidate the incidence and implications of this potentially serious complication.
Mass Spectrometric Studies at High Temperatures. VIII. The Sublimation Pressure of Iron(II) Fluoride (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMass Spectrometric Studies at High Temperatures. VIII. The Sublimation Pressure of Iron(II) FluorideRichard A. Kent and John L. MargraveCite this: J. Am. Chem. Soc. 1965, 87, 21, 4754–4756Publication Date (Print):November 1, 1965Publication History Published online1 May 2002Published inissue 1 November 1965https://pubs.acs.org/doi/10.1021/ja00949a016https://doi.org/10.1021/ja00949a016research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases (2020)

Adenosine is involved in a range of physiological and pathological effects through membrane-bound receptors linked to G proteins. There are four subtypes of adenosine receptors, described as A<sub>1</sub>AR, A<sub>2A</sub>AR, A<sub>2B</sub>AR, and A<sub>3</sub>AR, which are the center of cAMP signal pathway-based drug development. Several types of agonists, partial agonists or antagonists, and allosteric substances have been synthesized from these receptors as new therapeutic drug candidates. Research efforts surrounding A<sub>1</sub>AR and A<sub>2A</sub>AR are perhaps the most enticing because of their concentration and affinity; however, as a consequence of distressing conditions, both A<sub>2B</sub>AR and A<sub>3</sub>AR levels might accumulate. This review focuses on the biological features of each adenosine receptor as the basis of ligand production and describes clinical studies of adenosine receptor-associated pharmaceuticals in human diseases.
Exogenous application of abscisic acid or triadimefon affects the recovery of <i>Zea mays</i> seedlings from heat shock (1988)

Maize seedlings ( Zea mays L. cv. DK 246) grown for 1–4 days in the presence of abscisic acid (ABA) or triadimefon (a fungicide) demonstrated an enhanced ability to withstand the effects of a 3‐h sub‐lethal (40°C) or lethal (45°C) heat shock. Both the ABA and triadimefon treatments were applied solely to the roots of seedlings; however, the ability to withstand a heat shock was induced in both the root and the shoot. The level of protection provided by these agents was dependent upon the time that plants were exposed to them; prolonged exposure reduced tolerance to subsequent stress.
Detection of Coronary Plaque by Computed Tomography With a Novel Plaque Analysis System, `Plaque Map', and Comparison With Intravascular Ultrasound and Angioscopy (2004)

MDCT with the 'Plaque Map' system can noninvasively characterize plaque in patients with ACS.
Deep UV ANR Photoresists For 248 nm Excimer Laser Photolithography (1989)

This paper describes the development of deep UV resist materials based on chemically amplified crosslinking systems for use in excimer laser photolithography at the KrF lasing wavelength of 248 nm. This work will describe the use of a transparent resin, polyp-vinyl)phenol, which has excellent plasma etch resistance and demonstrates high resolution (sub half-micron line-space pairs for a 1.0 micron thick film) when used in an Advanced Negative Resist (ANR) formulation, XP-8843. Under 140C post-exposure bake conditions, XP-8843 exhibits fast photospeed (15 mJ/cm<sup>2</sup>), high contrast (4.1), vertical sidewalls, and good process latitude.
Adaptation of the Electrically Evoked Compound Action Potential (ECAP) Recorded from Nucleus CI24 Cochlear Implant Users (2007)

Cochlear implant users experienced varying degrees of long-term adaptation in response to continuous electrical stimulation. The effects of adaptation on the ECAP were apparent even at stimulation rates as low as 80 Hz. Although variations in the amount of adaptation are likely to reflect cross-subject differences in the status of the auditory nerve, no predictable relationship was found between these physiologic measures of peripheral neural function and either word recognition or the relationship between ECAP thresholds and MAP levels.
A fast 8K &#215; 8 mixed CMOS static RAM (1985)

This paper describes a fast 8K × 8 static RAM fabricated with a mixed CMOS technology. To realize a fast access time and yet a low active power, a block-oriented die architecture with four submodules and a new sense amplifier are applied. An address access time of 34 ns and a chip select access time of 38 ns have been achieved at an active power of 90 mW. In addition to redundant memory cells, the RAM incorporates a spare element disable (SED) function to make it easy to obtain the information of the replaced memory cell. Another feature is a high latchup immunity of the CMOS peripheral circuits. This is obtained from an optimized well structure and guard bands around the wells. A 2-µm design rule combined with the double-level polysilicon layer allowed for layout of the NMOS memory cell in 266.5 µm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and design of the die in 34.3 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Aslib Cranfield research project - Factors determining the performance of indexing systems; Volume 2, Test results (1966)

The test results are presented for a number of different index languages using various devices which affect recall or precision. Within the environment of this test, it is shown that the best performance was obtained with the group of eight index languages which used single terms. The group of fifteen index languages which were based on concepts gave the worst performance, while a group of six index languages based on the Thesaurus of Engineering Terms of the Engineers Joint Council were intermediary. Of the single term index languages, the only method of improving performance was to group synonyms and word forms, and any broader groupings of terms depressed performance. The use of precision devices such as links gave no advantage as compared to the basic device of simple coordination.\nAll results have to be considered within the context of the experimental environment, but they can be said to substantiate or clarify many of the findings of Cranfield I. It is conclusively shown that an inverse relationship exists between recall and precision, whatever the variable may be that is being changed. The two factors which appear most likely to affect performance are the level of exhaustivity of indexing and the level of specificity of the terms in the index language. For any given operational situation, the optimum levels cannot be categorically stated in advance, but can only be determined by an evaluation of the system, the main consideration probably being the subject field.\nIt would be unusual if the characteristics of the subject field used for this test were such as to make it unique, so the high performance obtained with the single terms in natural language can be considered to be of some importance in regard to the use of natural language text as input to mechanised systems.
Update on Spondyloarthropathies (2002)

Spondyloarthropathies are a cluster of interrelated and overlapping chronic inflammatory rheumatic diseases that primarily include ankylosing spondylitis, reactive arthritis, and the arthritis associated with psoriasis and inflammatory bowel diseases. The primary pathologic sites are the entheses (the sites of bony insertion of ligaments and tendons); the axial skeleton, including the sacroiliac joints; the limb joints; and some nonarticular structures, such as the gut, skin, eye, and aortic valve. Although spondyloarthropathies are not associated with rheumatoid factor, they show a strong association with HLA-B27; however, this association varies markedly among various spondyloarthropathies and among ethnic groups. The most widely used classification criterion, from the European Spondyloarthropathy Study Group, encompasses the currently recognized wider disease spectrum, with a sensitivity and specificity that generally exceed 85%. Spondyloarthropathies occur in genetically predisposed persons and are triggered by environmental factors, but the cellular and molecular mechanisms of inflammation are not yet fully understood. Chlamydial and many enterobacterial infections can trigger reactive arthritis, but an infectious trigger for ankylosing spondylitis has not yet been established. HLA-B27 itself is involved in enhancing genetic susceptibility, but the underlying molecular basis is still unknown; additional genes include the putative susceptibility genes for Crohn disease, ulcerative colitis, and psoriasis. A specific susceptibility gene for Crohn disease, NOD2, is located on chromosome 16q12, and one of the candidate genes for psoriasis, PSORS1, has been mapped to a 60-kb fragment on chromosome 6p, which is telomeric to the HLA-C locus. This paper reviews the efficacy of anti-tumor necrosis factor-alpha therapy and other therapeutic advances.
Basic statistics for clinicians: 4. Correlation and regression. (1995)

Correlation and regression help us to understand the relation between variables and to predict patients' status in regard to a particular variable of interest. Correlation examines the strength of the relation between two variables, neither of which is considered the variable one is trying to predict (the target variable). Regression analysis examines the ability of one or more factors, called independent variables, to predict a patient's status in regard to the target or dependent variable. Independent and dependent variables may be continuous (taking a wide range of values) or binary (dichotomous, yielding yes-or-no results). Regression models can be used to construct clinical prediction rules that help to guide clinical decisions. In considering regression and correlation, clinicians should pay more attention to the magnitude of the correlation or the predictive power of the regression than to whether the relation is statistically significant.
An Automated Fixed-Point Optimization Tool in MATLAB XSG/SynDSP Environment (2011)

This paper presents an automated tool for floating-point to fixed-point conversion. The tool is based on previous work that was built in MATLAB/Simulink environment and Xilinx System Generator support. The tool is now extended to include Synplify DSP blocksets in a seamless way from the users' view point. In addition to FPGA area estimation, the tool now also includes ASIC area estimation for end-users who choose the ASIC flow. The tool minimizes hardware cost subject to mean-squared quantization error (MSE) constraints. To obtain more accurate ASIC area estimations with synthesized results, 3 performance levels are available to choose from, suitable for high-performance, typical, or low-power applications. The use of the tool is first illustrated on an FIR filter to achieve over 50% area savings for MSE specification of 10 −6 as compared to all 16-bit realization. More complex optimization results for chip-level designs are also demonstrated.
Improved efficiency of Cu(In,Ga)Se/sub 2/ thin film solar cells with chemically deposited ZnS buffer layers by air-annealing-formation of homojunction by solid phase diffusion (2002)

The authors found that a role of the annealing process in CBD-ZnS/CIGS solar cells is the diffusion of Zn and S into CIGS thin films even at relatively low temperature of 200/spl deg/C. A new technique to form a homojunction of CIGS thin film solar cells by Zn-diffusion from ZnS layer is proposed, 17.7 % efficiency Cd-free CIGS solar cell has been fabricated by optimizing the annealing process, thickness of buffer layers, and CIGS absorber layers. This result suggests that high efficiency CIGS thin film solar cells can be achieved even if Cd is not utilized.