gebhart/patrepeval huggingface dataset:
Epithelial Membrane Protein-1, Peripheral Myelin Protein 22, and Lens Membrane Protein 20 Define a Novel Gene Family (1995)

Peripheral myelin protein 22 (PMP22) is expressed in many tissues but mainly by Schwann cells as a component of compact myelin of the peripheral nervous system (PNS). Mutations affecting PMP22 are associated with hereditary motor and sensory neuropathies. Although these phenotypes are restricted to the PNS, PMP22 is thought to play a dual role in myelin formation and in cell proliferation. We describe the cloning and characterization of epithelial membrane protein-1 (EMP-1), a putative four-transmembrane protein of 160 amino acids with 40% amino acid identity to PMP22. EMP-1 and PMP22 are co-expressed in most tissues but with differences in relative expression levels. EMP-1 is most prominently found in the gastrointestinal tract, skin, lung, and brain but not in liver. In the corpus gastricum, EMP-1 protein can be detected in epithelial cells of the gastric pit and isthmus of the gastric gland in a pattern consistent with plasma membrane association. EMP-1 and PMP22 mRNA levels are inversely regulated in the degenerating rat sciatic nerve after injury and by growth arrest in NIH 3T3 fibroblasts. The discovery of EMP-1 as the second member of a novel gene family led to the identification of the lens-specific membrane protein 20 (MP20) as a third but distant relative. The proteins of this family are likely to serve similar functions possibly related to cell proliferation and differentiation in a variety of cell types.
Optimization of gene expression in<i>Streptomyces tividans</i>by a transcription terminator (1987)

The ability of an inverted repeat sequence (IRS) from the 3' end of the aph gene from Streptomyces fradiae to induce transcription termination in vivo has been examined. As a model system, a DNA fragment encoding the human interferon alpha 2 inserted in the Streptomyces plasmid pIJ702 was used. When the IRS was inserted downstream from this sequence and transcription assayed in Streptomyces lividans, highly efficient (approximately 90%) transcription termination was observed occurring immediately after the 3' terminus of the dyad. In contrast, gene constructions lacking the IRS transcribed longer mRNAs. Moreover, the IRS gave rise to increased amounts of the hIFN alpha 2 suggesting that the putative stem-loop structure stabilised the transcript.
Solution of MgO, CaO, and TiO <sub>2</sub> in α‐AI <sub>2</sub> O <sub>3</sub> (1994)

Atomistic simulation methods are used to predict the preferred solution mechanisms and their associated energies. Both full‐ and partial‐charge models are discussed. It was found that defect clustering always results in a significant lowering of the solution energies but does not change the preferred solution reaction of any of the oxides. The large size of the Ca 2+ ion results not only in a higher solution energy (lower solubility) for CaO compared to MgO but also to a different preferred compensation mechanism. The predicted energy for the cosolution of MgO and TiO 2 is dramatically smaller than for either oxide separately. Conversely, whereas solution of TiO 2 aids the solution of CaO, additions of CaO do not support TiO 2 , Solution.
Finding nearest neighbors in growth-restricted metrics (2002)

Most research on nearest neighbor algorithms in the literature has been focused on the Euclidean case. In many practical search problems however, the underlying metric is non-Euclidean. Nearest neighbor algorithms for general metric spaces are quite weak, which motivates a search for other classes of metric spaces that can be tractably searched.In this paper, we develop an efficient dynamic data structure for nearest neighbor queries in growth-constrained metrics. These metrics satisfy the property that for any point q and number r the ratio between numbers of points in balls of radius 2r and r is bounded by a constant. Spaces of this kind may occur in networking applications, such as the Internet or Peer-to-peer networks, and vector quantization applications, where feature vectors fall into low-dimensional manifolds within high-dimensional vector spaces.
Using Machine Learning Ensemble Methods to Predict Execution Time of e-Science Workflows in Heterogeneous Distributed Systems (2019)

Effective planning and optimized execution of the e-Science workflows in distributed systems, such as the Grid, need predictions of execution times of the workflows. However, predicting the execution times of e-Science workflows in heterogeneous distributed systems is a challenging job due to the complex structure of workflows, variations due to input problem-sizes, and heterogeneous and dynamic nature of the shared resources. To this end, we propose two novel workflow execution time-prediction methods based on the machine learning ensemble models. In this paper, we showcase our approach for two different real Grid environments. Our approach can effectively predict the execution time of the scientific workflow applications in the Grid for various problem sizes, Grid sites, and runtime environments. We characterized the workflow performance in the Grid using the attributes that define structure of workflow as well as the execution environment. Contrary to common ensembles, our ensemble systems employed three strong learners, which balance the weaknesses of each other by their strengths to model the workflow execution times. The proposed methods have been thoroughly evaluated for three real-world e-science workflow applications. The experimental results demonstrated that our proposed multi-model ensemble models can significantly decrease the prediction error (by 50%, on average) as compared with methods based on the radial basis function neural network, local learning, and performance templates. The proposed methods can also be applied with similar effectiveness and without any major modification for other heterogeneous distributed environments, such as the Cloud.
The Architectural Implications of Autonomous Driving (2018)

Autonomous driving systems have attracted a significant amount of interest recently, and many industry leaders, such as Google, Uber, Tesla, and Mobileye, have invested a large amount of capital and engineering power on developing such systems. Building autonomous driving systems is particularly challenging due to stringent performance requirements in terms of both making the safe operational decisions and finishing processing at real-time. Despite the recent advancements in technology, such systems are still largely under experimentation and architecting end-to-end autonomous driving systems remains an open research question. To investigate this question, we first present and formalize the design constraints for building an autonomous driving system in terms of performance, predictability, storage, thermal and power. We then build an end-to-end autonomous driving system using state-of-the-art award-winning algorithms to understand the design trade-offs for building such systems. In our real-system characterization, we identify three computational bottlenecks, which conventional multicore CPUs are incapable of processing under the identified design constraints. To meet these constraints, we accelerate these algorithms using three accelerator platforms including GPUs, FPGAs, and ASICs, which can reduce the tail latency of the system by 169x, 10x, and 93x respectively. With accelerator-based designs, we are able to build an end-to-end autonomous driving system that meets all the design constraints, and explore the trade-offs among performance, power and the higher accuracy enabled by higher resolution cameras.
Identification and Characterization of <i>MAE1</i> , the <i>Saccharomyces cerevisiae</i> Structural Gene Encoding Mitochondrial Malic Enzyme (1998)

Pyruvate, a precursor for several amino acids, can be synthesized from phosphoenolpyruvate by pyruvate kinase. Nevertheless, pyk1 pyk2 mutants of Saccharomyces cerevisiae devoid of pyruvate kinase activity grew normally on ethanol in defined media, indicating the presence of an alternative route for pyruvate synthesis. A candidate for this role is malic enzyme, which catalyzes the oxidative decarboxylation of malate to pyruvate. Disruption of open reading frame YKL029c, which is homologous to malic enzyme genes from other organisms, abolished malic enzyme activity in extracts of glucose-grown cells. Conversely, overexpression of YKL029c/MAE1 from the MET25 promoter resulted in an up to 33-fold increase of malic enzyme activity. Growth studies with mutants demonstrated that presence of either Pyk1p or Mae1p is required for growth on ethanol. Mutants lacking both enzymes could be rescued by addition of alanine or pyruvate to ethanol cultures. Disruption of MAE1 alone did not result in a clear phenotype. Regulation of MAE1 was studied by determining enzyme activities and MAE1 mRNA levels in wild-type cultures and by measuring beta-galactosidase activities in a strain carrying a MAE1::lacZ fusion. Both in shake flask cultures and in carbon-limited chemostat cultures, MAE1 was constitutively expressed. A three- to fourfold induction was observed during anaerobic growth on glucose. Subcellular fractionation experiments indicated that malic enzyme in S. cerevisiae is a mitochondrial enzyme. Its regulation and localization suggest a role in the provision of intramitochondrial NADPH or pyruvate under anaerobic growth conditions. However, since null mutants could still grow anaerobically, this function is apparently not essential.
Constant potential amperometric detection of carbohydrates at a copper-based chemically modified electrode (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConstant potential amperometric detection of carbohydrates at a copper-based chemically modified electrodeSunil V. Prabhu and Richard P. BaldwinCite this: Anal. Chem. 1989, 61, 8, 852–856Publication Date (Print):April 15, 1989Publication History Published online1 May 2002Published inissue 15 April 1989https://pubs.acs.org/doi/10.1021/ac00183a014https://doi.org/10.1021/ac00183a014research-articleACS PublicationsRequest reuse permissionsArticle Views598Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Glioma cancer stem cells induce immunosuppressive macrophages/microglia (2010)

Macrophages (MΦs)/microglia that constitute the dominant tumor-infiltrating immune cells in glioblastoma are recruited by tumor-secreted factors and are induced to become immunosuppressive and tumor supportive (M2). Glioma cancer stem cells (gCSCs) have been shown to suppress adaptive immunity, but their role in innate immunity with respect to the recruitment and polarization of MΦs/microglia is unknown. The innate immunosuppressive properties of the gCSCs were characterized based on elaborated MΦ inhibitory cytokine-1 (MIC-1), transforming growth factor (TGF-β1), soluble colony-stimulating factor (sCSF), recruitment of monocytes, inhibition of MΦ/microglia phagocytosis, induction of MΦ/microglia cytokine secretion, and the inhibition of T-cell proliferation. The role of the signal transducer and activator of transcription 3 (STAT3) in mediating innate immune suppression was evaluated in the context of the functional assays. The gCSCs produced sCSF-1, TGF-β1, and MIC-1, cytokines known to recruit and polarize the MΦs/microglia to become immunosuppressive. The gCSC-conditioned medium polarized the MΦ/microglia to an M2 phenotype, inhibited MΦ/microglia phagocytosis, induced the secretion of the immunosuppressive cytokines interleukin-10 (IL-10) and TGF-β1 by the MΦs/microglia, and enhanced the capacity of MΦs/microglia to inhibit T-cell proliferation. The inhibition of phagocytosis and the secretion of IL-10 were reversed when the STAT3 pathway was blocked in the gCSCs. The gCSCs modulate innate immunity in glioblastoma by inducing immunosuppressive MΦs/microglia, and this capacity can be reversed by inhibiting phosphorylated STAT3.
Cuando el Índice de Fuerza Relativa Conoció al Árbol Binomial (2009)

En este articulo entregamos un metodo para predecir una popular herramienta del analisis tecnico: el Indice de Fuerza Relativa (RSI). Este metodo esta basado en el supuesto de que el precio del activo puede ser caracterizado por el modelo binomial, el cual es ampliamente usado para valorar opciones. El algoritmo es tan sencillo de implementar como la valoracion de una opcion de compra europea. Se presenta la aplicacion del metodo a la paridad peso � dolar, donde los resultados muestran que nuestra propuesta es superior a la modelacion ARMA.
Exacerbation of Atopic Dermatitis after Bacillus Calmette-Guérin Vaccination (1998)

In two children with atopic dermatitis, routine vaccination with bacillus Calmette-Guérin (BCG) was followed by severe exacerbation of skin disease. If the sequence is cause and effect, a possible mechanism is stimulation of a Th2 lymphocyte cytokine profile by the vaccine, with migration of activated lymphocytes to inflamed skin. In children with active atopic dermatitis, BCG vaccination is best deferred until remission.
Practical fluid mechanics for engineering applications (2000)

Basic concepts of fluid mechanics fluid statics equations of fluid motion flow in pipes flow in open channels flow measurement in closed conduits forces on immersed objects unsteady flow. Appendices: coversation factors pipe schedules properties of areas, pipes and tubing fluid properties.
Theory of dynamic permeability and tortuosity in fluid-saturated porous media (1987)

We consider the response of a Newtonian fluid, saturating the pore space of a rigid isotropic porous medium, subjected to an infinitesimal oscillatory pressure gradient across the sample. We derive the analytic properties of the linear response function as well as the high- and low-frequency limits. In so doing we present a new and well-defined parameter Λ, which enters the high-frequency limit, characteristic of dynamically connected pore sizes. Using these results we construct a simple model for the response in terms of the exact high- and low-frequency parameters; the model is very successful when compared with direct numerical simulations on large lattices with randomly varying tube radii. We demonstrate the relevance of these results to the acoustic properties of non-rigid porous media, and we show how the dynamic permeability/tortuosity can be measured using superfluid 4 He as the pore fluid. We derive the expected response in the case that the internal walls of the pore space are fractal in character.
A New Information Fusion Method for Bimodal Robotic Emotion Recognition (2008)

Emotion recognition has become a popular area in human-robot interaction research. Through recognizing facial expressions, a robot can interact with a person in a more friendly manner. In this paper, we proposed a bimodal emotion recognition system by combining image and speech signals. A novel probabilistic strategy has been studied for a support vector machine (SVM)-based classification design to assign statistically information-fusion weights for two feature modalities. The fusion weights are determined by the distance between test data and the classification hyperplane and the standard deviation of training samples. In the latter bimodal SVM classification, the recognition result with higher weight is selected. The complete procedure has been implemented in a DSP-based embedded system to recognize five facial expressions on-line in real time. The experimental results show that an average recognition rate of 86.9% is achieved, a 5% improvement compared to using only image information.
A mechanistic account of the mirror effect for word frequency: A computational model of remember-know judgments in a continuous recognition paradigm. (2000)

A theoretical account of the mirror effect for word frequency and of dissociations in the pattern of responding Remember vs. Know (R vs. K) for low- and high-frequency words was tested both empirically and computationally by comparing predicted with observed data theory in 3 experiments. The SAC (Source of Activation Confusion) theory of memory makes the novel prediction of more K responses for high- than for low-frequency words, for both old and new items. Two experiments used a continuous presentation and judgment paradigm that presented words up to 10 times. The computer simulation closely modeled the pattern of results, fitting new Know and Remember patterns of responding at each level of experimental presentation and for both levels of word frequency for each participant. Experiment 3 required list discrimination after each R response (Group 1) or after an R or K response (Group 2). List accuracy was better following R responses. All experiments were modeled using the same parameter values.
Practical attenuated phase-shifting mask with a single-layer absorptive shifter of MoSiO and MoSiON for ULSI fabrication (2002)

Attenuated phase-shifting mask with a single-layer absorptive shifter with MoSiO or MoSiON films has been developed. These films satisfies the condition both the 180-degree phase shift and the transmittance between 5 and 20%. Conventional mask processes, such as etching, cleaning, defect inspection and defect repair, can be used for the fabrication. Defect-free masks for hole layers of 64 M-bit DRAM have been obtained. Using this mask, the focus depth of 0.35-/spl mu/m hole is improved from 0.6 /spl mu/m to 1.5 /spl mu/m.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Changes in BMI and waist circumference among primary and secondary school students from 2005 to 2010 in Anhui, China (2013)

The average value of BMI and WC among primary and secondary school students has increased dramatically from 2005 to 2010 in Anhui, China. Changes in WC have greatly exceeded those in BMI, showing that WC is a good proxy for central fatness rather than BMI.
Impressions management and judgement using clothing styles (2008)

Shakespeare wrote 'For the apparel oft proclaims the man' (Hamlet, 1:3) suggesting that even centuries ago clothing and impressions were intimately intertwined. The purpose of this paper is to present the results from a qualitative study on clothing styles and the individual's impressions management. The philosophical foundation of this research is that consumers draw specific conclusions about other people based on their clothing. In particular, this study focused on the judgment process during the rite of passage as teenagers become emerging adults and how they use clothing. The conclusions of this study are that consumers are able to instantly judge others because of their clothing choices. These judgments can be made with and without brand knowledge and that the consumer is aware of the judgment process as they present their own adult identity by wearing personally interpreted clothing styles.
SecDFyajC forms a heterotetrameric complex with YidC (2002)

The Escherichia coli preprotein translocase is composed of a "preprotein conducting channel" domain that consists of the peripherally bound translocation ATPase SecA and the heterotrimeric SecYEG membrane protein complex. SecD, SecF, and YajC form another heterotrimeric complex that can associate with the SecYEG complex. YidC is an essential membrane protein that plays a role in the integration of newly synthesized membrane proteins, and has been shown to co-purify with SecYEG when all translocase components are overproduced. Here, we demonstrate that under conditions that YidC co-purifies with overproduced SecDFyajC it does not co-purify with overproduced SecYEG. Moreover, this interaction of YidC with the SecDFyajC complex is also found at chromosomal protein levels of SecD, SecF and YajC. Closer examination of the SecDFyajC-YidC complex showed that YidC binds to SecD and SecF, whereas YajC interacts only with SecF. As SecF and YajC have previously been shown to interact with SecY, we propose that these two proteins link the heterotetrameric SecDFyajC-YidC complex to the SecYEG complex.
ChemInform Abstract: THERMOLYSIS AND PHOTOLYSIS OF SOME SILA‐ AND DISILACYCLOBUTANES (1981)

Abstract Die Thermolyse der 1,1‐di‐ oder l,1,2‐tri‐substituierten l‐Silacyclobutane (I) bzw. (III) führt zu den 1,3‐ ; Disi1acyclobutanen(II).
A New Era for Crew Recovery at Continental Airlines (2003)

Airlines face schedule disruptions daily because of unexpected events, including inclement weather, aircraft mechanical problems, and crew unavailability. These disruptions can cause flight delays and cancellations. As a result, crews may not be in position to service their remaining scheduled flights. Airlines must reassign crews quickly to cover open flights and to return them to their original schedules in a cost-effective manner while honoring all government regulations, contractual obligations, and quality-of-life requirements. CALEB Technologies developed the CrewSolver decision-support system for Continental Airlines to generate globally optimal, or near optimal, crew-recovery solutions. Since its implementation, the system has dealt successfully with several high-profile events, including the December 2000 and March 2001 Nor'easter snowstorms, the June 2001 Houston flood, and most dramatically, the September 11th terrorist attacks. In each case, Continental recovered quickly and obtained overall benefits worth millions of dollars. Continental estimates that in 2001 the CrewSolver system helped it save approximately US $40 million for major disruptions only.
Determination of ion populations and solvent content as functions of redox state and pH in polyaniline (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of ion populations and solvent content as functions of redox state and pH in polyanilineDuke Orata and Daniel A. ButtryCite this: J. Am. Chem. Soc. 1987, 109, 12, 3574–3581Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/ja00246a013https://doi.org/10.1021/ja00246a013research-articleACS PublicationsRequest reuse permissionsArticle Views1019Altmetric-Citations454LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts