gebhart/patrepeval huggingface dataset:
[Plasma L-carnitine levels in children with celiac disease]. (1992)

Carnitine is a very important co-factor for the metabolism of fatty acids, because it is the necessary carrier for the passage of acyl groups inside the mitochondria, where beta-oxidation takes place. In the human body the total pool of carnitine is made by two fractions, one being endogenous and the second exogenous. The absorption of exogenous carnitine takes place mainly at duodenal-jejunal level by an active transport mechanism based on amino acid carrier. Plasma L-carnitine concentrations have been measured in 66 coeliac patients (mean age: 7 years and 4 months). Thirty three of them were on a free diet and the other 33 were on a gluten-free diet for at last six month. In 10 patients we studied plasma L-carnitine levels both on a free diet and on a gluten-free diet. As controls we examined 33 healthy children comparable for age. Plasma L-carnitine concentrations have been measured by a spectrophotometrical method according to Marquis and Fritz's technique and subsequently modified by Pearson and Seccombe. In the 66 coeliac patients the mean values of serum L-carnitine were significantly lower than those in the controls (p < 0.001). The levels were significantly lower in patients a free diet with respect to those on gluten-free diet (p < 0.01). The 10 subjects who were examined both on free diet and on gluten-free diet showed an increase of plasma concentrations in the latter condition.(ABSTRACT TRUNCATED AT 250 WORDS)
Gingiva as a Source of Stem Cells with Therapeutic Potential (2013)

Postnatal connective tissues contain phenotypically heterogeneous cells populations that include distinct fibroblast subpopulations, pericytes, myofibroblasts, fibrocytes, and tissue-specific mesenchymal stem cells (MSCs). These cells play key roles in tissue development, maintenance, and repair and contribute to various pathologies. Depending on the origin of tissue, connective tissue cells, including MSCs, have different phenotypes. Understanding the identity and specific functions of these distinct tissue-specific cell populations may allow researchers to develop better treatment modalities for tissue regeneration and find novel approaches to prevent pathological conditions. Interestingly, MSCs from adult oral mucosal gingiva possess distinct characteristics, including neural crest origin, multipotent differentiation capacity, fetal-like phenotype, and potent immunomodulatory properties. These characteristics and an easy, relatively noninvasive access to gingival tissue, and fast tissue regeneration after tissue biopsy make gingiva an attractive target for cell isolation for therapeutic purposes aiming to promote tissue regeneration and fast, scar-free wound healing. The purpose of this review is to discuss the identity, phenotypical heterogeneity, and function of gingival MSCs and summarize what is currently known about their properties, role in scar-free healing, and their future therapeutic potential.
In Situ Generation of Active Sites in Olefin Metathesis (2012)

The depth of our understanding in catalysis is governed by the information we have about the number of active sites and their molecular structure. The nature of an active center on the surface of a working heterogeneous catalyst is, however, extremely difficult to identify and precise quantification of active species is generally missing. In metathesis of propene over dispersed molybdenum oxide supported on silica, only 1.5% of all Mo atoms in the catalyst are captured to form the active centers. Here we combine infrared spectroscopy in operando with microcalorimetry and reactivity studies using isotopic labeling to monitor catalyst formation. We show that the active Mo(VI)-alkylidene moieties are generated in situ by surface reaction of grafted molybdenum oxide precursor species with the substrate molecule itself gaining insight into the pathways limiting the number of active centers on the surface of a heterogeneous catalyst. The active site formation involves sequential steps requiring multiple catalyst functions: protonation of propene to surface Mo(VI)-isopropoxide species driven by surface Brønsted acid sites, subsequent oxidation of isopropoxide to acetone in the adsorbed state owing to the red-ox capability of molybdenum leaving naked Mo(IV) sites after desorption of acetone, and oxidative addition of another propene molecule yielding finally the active Mo(VI)-alkylidene species. This view is quite different from the one-step mechanism, which has been accepted in the community for three decades, however, fully consistent with the empirically recognized importance of acidity, reducibility, and strict dehydration of the catalyst. The knowledge acquired in the present work has been successfully implemented for catalyst improvement. Simple heat treatment after the initial propene adsorption doubled the catalytic activity by accelerating the oxidation and desorption-capturing steps, demonstrating the merit of knowledge-based strategies in heterogeneous catalysis. Molecular structure of active Mo(VI)-alkylidene sites derived from surface molybdena is discussed in the context of similarity to the highly active Schrock-type homogeneous catalysts.
Novel multiresolution approach for an adaptive structured light system (2008)

3-D triangulation measurement systems with a fixed geometrical configuration have practical limitations that make them inappropriate for a wide variety of applications. The reason is that the ratio between the depth recovery error and the lateral extension is a constant that depends on the geometrical setup. Therefore, with a fixed triangulation setup, there is a tradeoff between field of view and depth resolution. As a consequence, measuring large areas with low depth recovery error necessitates the use of multiresolution techniques. In this work, we propose a multiresolution technique based on a camera-projector system previously calibrated and a second auxiliary camera that can move freely. The method consists of making first a measurement with a large field of view (coarse measurement). Afterwards, the geometrical configuration of the 3-D rig is changed to acquire a small field of view (fine measurement) that is referred to the original reference system and calibration parameters by means of the auxiliary camera. Using this method, a multiresolution reconstruction is possible without any optimization, registration, or recalibration process. Experimental results, which show a decrease of approximately one order of magnitude in the depth recovery error between fine and coarse measures, demonstrate the feasibility of the proposed method.
The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFR  and FIP1L1-PDGFR  in vitro and in vivo (2005)

AMN107 is a small molecule tyrosine kinase inhibitor developed, in the first instance, as a potent inhibitor of breakpoint cluster region-abelson (BCR-ABL). We tested its effectiveness against fusion tyrosine kinases TEL-platelet-derived growth factor receptorbeta (TEL-PDGFRbeta) and FIP1-like-1 (FIP1L1)-PDGFRalpha, which cause chronic myelomonocytic leukemia and hypereosinophilic syndrome, respectively. In vitro, AMN107 inhibited proliferation of Ba/F3 cells transformed by both TEL-PDGFRbeta and FIP1L1-PDGFRalpha with IC50 (inhibitory concentration 50%) values less than 25 nM and inhibited phosphorylation of the fusion kinases and their downstream signaling targets. The imatinib mesylate-resistant mutant TEL-PDGFRbeta T681I was sensitive to AMN107, whereas the analogous mutation in FIP1L1-PDGFRalpha, T674I, was resistant. In an in vivo bone marrow transplantation assay, AMN107 effectively treated myeloproliferative disease induced by TEL-PDGFRbeta and FIP1L1-PDGFRalpha, significantly increasing survival and disease latency and reducing disease severity as assessed by histopathology and flow cytometry. In summary, AMN107 can inhibit myeloid proliferation driven by TEL-PDGFRbeta and FIP1L1-PDGFRalpha and may be a useful drug for treatment of patients with myeloproliferative disease who harbor these kinase fusions.
The Action of Elementary Fluorine upon Organic Compounds. XX. The Fluorination of Mono-, Di- and Trimethylamine, Ethylenediamine and Ethyleneimine<sup>1</sup> (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Action of Elementary Fluorine upon Organic Compounds. XX. The Fluorination of Mono-, Di- and Trimethylamine, Ethylenediamine and Ethyleneimine1Jay A. Gervasi, Morton Brown, and Lucius A. BigelowCite this: J. Am. Chem. Soc. 1956, 78, 8, 1679–1682Publication Date (Print):April 1, 1956Publication History Published online1 May 2002Published inissue 1 April 1956https://doi.org/10.1021/ja01589a051RIGHTS & PERMISSIONSArticle Views103Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (479 KB) Get e-Alerts Get e-Alerts
Analog VLSI Focal-Plane Array With Dynamic Connections for the Estimation of Piecewise-Smooth Optical Flow (2004)

An analog very large-scale integrated (aVLSI) sensor is presented that is capable of estimating optical flow while detecting and preserving motion discontinuities. The sensor's architecture is composed of two recurrently connected networks. The units in the first network (the optical-flow network) collectively estimate two-dimensional optical flow, where the strength of their nearest-neighbor coupling determines the degree of motion integration. While the coupling strengths in our previous implementations were globally set and adjusted by the operator, they are now dynamically and locally controlled by a second on-chip network (the motion-discontinuity network). The coupling strengths are set such that visual motion integration is inhibited across image locations that are likely to represent motion boundaries. Results of a prototype sensor illustrate the potential of the approach and its functionality under real-world conditions.
An integrated optical preprocessor for multichannel analog data (1978)

As a precursor to the construction of a 16-channel device, a 3-channel integrated optical data preprocessor has been fabricated and tested. The device, which is fabricated in an outdiffused LiNbO3 waveguide, provides a signal related to the channel-by-channel difference between a prerecorded reference set and an incoming data set which is presented in the form of parallel analog voltages. The data are impressed upon the guided wave as a set of electrooptically induced phase shifts, and the comparison to the reference set is performed by holographic subtraction. The reference set can either be introduced as a separate operation or it can be 'learned' by the preprocessor during operation.
The Rare Earth Metals and their Compounds. VIII. An Improved Method for the Synthesis of Some Rare Earth Acetylacetonates<sup>1a</sup> (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Rare Earth Metals and their Compounds. VIII. An Improved Method for the Synthesis of Some Rare Earth Acetylacetonates1aJoseph G. Stites, C. N. McCarty, and Laurence L. QuillCite this: J. Am. Chem. Soc. 1948, 70, 9, 3142–3143Publication Date (Print):September 1, 1948Publication History Published online1 May 2002Published inissue 1 September 1948https://pubs.acs.org/doi/10.1021/ja01189a509https://doi.org/10.1021/ja01189a509research-articleACS PublicationsRequest reuse permissionsArticle Views1727Altmetric-Citations189LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antibiotic Treatment of Adults With Sore Throat by Community Primary Care Physicians (2001)

More than half of adults are treated with antibiotics for sore throat by community primary care physicians. Use of nonrecommended, more expensive, broader-spectrum antibiotics is frequent.
Formal Concept Analysis and Software Process Improvement (2003)

The paper focuses on the method of formal concept analysis in data analyzing for software process improvement. It sets up that not only the Software Quality Guarantee Platform being developed should have the common functions including enterprise process defining, process cutting out, executing and monitoring, and the normal data analysis tools such as OLAP, but also one should develop the novel data analysis tools based on formal methodology by starting with maturity definition of process data, so as to discover valuable new knowledge from large database and support continuous software process improvement. Further more,the paper demonstrates the software process data analysis using concept lattice in an example.
Minor Modifications to the Phosphate Groups and the C3′ Acyl Chain Length of Lipid A in Two Bordetella pertussis Strains, BP338 and 18-323, Independently Affect Toll-like Receptor 4 Protein Activation (2013)

Lipopolysaccharides (LPS) of Bordetella pertussis are important modulators of the immune system. Interaction of the lipid A region of LPS with the Toll-like receptor 4 (TLR4) complex causes dimerization of TLR4 and activation of downstream nuclear factor κB (NFκB), which can lead to inflammation. We have previously shown that two strains of B. pertussis, BP338 (a Tohama I-derivative) and 18-323, display two differences in lipid A structure. 1) BP338 can modify the 1- and 4'-phosphates by the addition of glucosamine (GlcN), whereas 18-323 cannot, and 2) the C3' acyl chain in BP338 is 14 carbons long, but only 10 or 12 carbons long in 18-323. In addition, BP338 lipid A can activate TLR4 to a greater extent than 18-323 lipid A. Here we set out to determine the genetic reasons for the differences in these lipid A structures and the contribution of each structural difference to the ability of lipid A to activate TLR4. We show that three genes of the lipid A GlcN modification (Lgm) locus, lgmA, lgmB, and lgmC (previously locus tags BP0399-BP0397), are required for GlcN modification and a single amino acid difference in LpxA is responsible for the difference in C3' acyl chain length. Furthermore, by introducing lipid A-modifying genes into 18-323 to generate isogenic strains with varying penta-acyl lipid A structures, we determined that both modifications increase TLR4 activation, although the GlcN modification plays a dominant role. These results shed light on how TLR4 may interact with penta-acyl lipid A species.
Access of viral proteins to mitochondria via mitochondria‐associated membranes (2009)

By exploiting host cell machineries, viruses provide powerful tools for gaining insight into cellular pathways. Proteins from two unrelated viruses, human CMV (HCMV) and HCV, are documented to traffic sequentially from the ER into mitochondria, probably through the mitochondria-associated membrane (MAM) compartment. The MAM are sites of ER-mitochondrial contact enabling the direct transfer of membrane bound lipids and the generation of high calcium (Ca2+) microdomains for mitochondria signalling and responses to cellular stress. Both HCV core protein and HCMV UL37 proteins are associated with Ca2+ regulation and apoptotic signals. Trafficking of viral proteins to the MAM may allow viruses to manipulate a variety of fundamental cellular processes, which converge at the MAM, including Ca2+ signalling, lipid synthesis and transfer, bioenergetics, metabolic flow, and apoptosis. Because of their distinct topologies and targeted MAM sub-domains, mitochondrial trafficking (albeit it through the MAM) of the HCMV and HCV proteins predictably involves alternative pathways and, hence, distinct targeting signals. Indeed, we found that multiple cellular and viral proteins, which target the MAM, showed no apparent consensus primary targeting sequences. Nonetheless, these viral proteins provide us with valuable tools to access the poorly characterised MAM compartment, to define its cellular constituents and describe how virus infection alters these to its own end. Furthermore, because proper trafficking of viral proteins is necessary for their function, discovering the requirements for MAM to mitochondrial trafficking of essential viral proteins may provide novel targets for the rational design of anti-viral drugs.
Pretreatment with Ibuprofen Augments Circulating Tumor Necrosis Factor- , Interleukin-6, and Elastase during Acute Endotoxinemia (1991)

Plasma levels of tumor necrosis factor-alpha (TNF alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6) were monitored after intravenous administration of Escherichia coli endotoxin with or without ibuprofen pretreatment to healthy volunteers. Intravenous endotoxin (n = 7) resulted in elevated plasma TNF alpha concentrations with maximal levels at 90 min (369 +/- 44 pg/ml, P less than .001 vs. saline controls, n = 7). The rise in TNF-alpha was followed by a rise in plasma IL-6 (27 +/- 12.8 ng/ml), peaking 30-90 min thereafter. Pretreatment with ibuprofen (n = 6) caused a significant augmentation and temporal shift in cytokine elaboration with maximal TNF alpha levels (627 +/- 136 pg/ml) at 120 min and IL-6 peaks (113 +/- 66 ng/ml) at 180 min. In ibuprofen-treated volunteers, the additional increase in TNF alpha was paralleled by increased levels of circulating elastase. In vitro experiments suggest a causal relationship between these events. Thus, the cyclooxygenase inhibitor ibuprofen blunts the clinical response to endotoxin but augments circulating cytokine levels and leukocyte degranulation.
Models and algorithms for operations scheduling problems with resource flexibility and schedule disruptions (2004)

This thesis addresses new classes of single-resource scheduling problems with resource flexibility and schedule disruption. We first consider two problems in which the scheduling firm has options to use additional resources to speed up the processing of a predetermined set of jobs. The usage of overtime or process time “compression” costs must be balanced against penalty costs for tardy job delivery. In the first problem, the firm must process all jobs from a static set of jobs at minimum total weighted tardiness plus overtime usage costs. We develop a novel new compact and relax algorithm for this problem. The second problem allows the firm to select a subset of jobs for processing that maximizes profit, where each job has associated revenue. We use a two-phase interval selection algorithm along with a compress and relax algorithm to solve this problem. 
We also consider two problems in which the set of jobs may be “dynamic,” meaning that the set of all jobs that require processing may not be known with certainty at the time the initial schedule must be developed. We first address a rescheduling problem with newly arriving jobs. The objective function is to minimize total cost, which includes schedule disruption costs, tardiness costs, and processing time compression costs. We apply linear programming techniques to solve the problem with a fixed sequence of jobs and use a heuristic based on very large scale neighborhood search (VLSN) techniques for the general problem. We then consider a predictive reactive schedule that accounts for the possibility of future uncertain job arrivals. The predictive schedule is generated by inserting idle time in the initial schedule to account for uncertain jobs. We discuss several predictive scheduling policies and reactive approaches for dealing with this uncertainty.
Cyclized Products from the Stobbe Condensation with δ-Keto-esters (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclized Products from the Stobbe Condensation with δ-Keto-estersD. L. TurnerCite this: J. Am. Chem. Soc. 1951, 73, 3, 1284–1287Publication Date (Print):March 1, 1951Publication History Published online1 May 2002Published inissue 1 March 1951https://pubs.acs.org/doi/10.1021/ja01147a122https://doi.org/10.1021/ja01147a122research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mobile Robot Autonomous Exploration and Navigation in Large-scale Indoor Environments (2019)

This work is intended to study the stages of exploring, localization and mapping of autonomous mobile robots and vehicles. In addition to the use of integrated and standard software, ROS has the possibility of creating small map data files recorded with the data provided by 2D Light Detection And Ranging (LiDAR) sensors. The low data density favours the increased efficiency during data processing. The metric maps register just enough information to create the topological nodes and edges in a relational map. Extensive experiments in both simulated environments and real-world applications show the effectiveness of the proposed method.