gebhart/patrepeval huggingface dataset:
Chitosan-Thioglycolic Acid as a Versatile Antimicrobial Agent (2013)

As functionalized chitosans hold great potential for the development of effective and broad-spectrum antibiotics, representative chitosan derivatives were tested for antimicrobial activity in neutral media: trimethyl chitosan (TMC), carboxy-methyl chitosan (CMC), and chitosan-thioglycolic acid (TGA; medium molecular weight: MMW-TGA; low molecular weight: LMW-TGA). Colony forming assays indicated that LMW-TGA displayed superior antimicrobial activity over the other derivatives tested: a 30 min incubation killed 100% Streptococcus sobrinus (Gram-positive bacteria) and reduced colony counts by 99.99% in Neisseria subflava (Gram-negative bacteria) and 99.97% in Candida albicans (fungi). To elucidate LMW-TGA effects at the cellular level, microscopic studies were performed. Use of fluorescein isothiocyanate (FITC)-labeled chitosan derivates in confocal microscopy showed that LMW-TGA attaches to microbial cell walls, while transmission electron microscopy indicated that this derivative severely affects cell wall integrity and intracellular ultrastructure in all species tested. We therefore propose LMW-TGA as a promising and effective broad-band antimicrobial compound.
Technical Note: A New Technique to Improve Video Stability by Digital Processing (1988)

In many cases video images taken with a telephoto lens or with a camera mounted on a moving vehicle or aircraft show motion caused by the vibration of the camera itself. Various mechanical antivibration devices have been used to reduce the vibration of the pickup system and improve video stability. A new technique to improve video stability by digital processing, analyzing and correcting the video motion electronically, has been developed at Japan Broadcasting Corp. (NHK). This corrective system works in real time either for live images or for videotaped images as they are broadcast.
Adrenergic α<sub>2C</sub>-Receptors Modulate the Acoustic Startle Reflex, Prepulse Inhibition, and Aggression in Mice (1998)

Studies on animal models of stress, anxiety, aggression, and sensorimotor gating have linked specific monoamine neurotransmitter abnormalities to the cognitive and behavioral disturbances associated with many affective neuropsychiatric disorders. Although alpha2-adrenoceptors (alpha2-ARs) have been suggested to have a modulatory role in these disorders, the specific roles of each alpha2-AR subtype (alpha2A, alpha2B, and alpha2C) are largely unknown. The restricted availability of relevant animal models and the lack of subtype-selective alpha2-AR drugs have precluded detailed studies in this area. Therefore, transgenic mice were used to study the possible role of the alpha2C-AR subtype in two well established behavioral paradigms: prepulse inhibition (PPI) of the startle reflex and isolation-induced aggression. The alpha2C-AR-altered mice appear grossly normal, but subtle changes have been observed in their brain dopamine (DA) and serotonin (5-HT) metabolism. In this study, the mice with targeted inactivation of the gene encoding alpha2C-ARs (alpha2C-KO) had enhanced startle responses, diminished PPI, and shortened attack latency in the isolation-aggression test, whereas tissue-specific overexpression of alpha2C-ARs (alpha2C-OE) was associated with opposite effects. Correlation analyses suggested that both the magnitude of the startle response and its relative PPI (PPI%) were modulated by the mutations. In addition, the differences in PPI, observed between drug-naive alpha2C-OE mice and their wild-type controls, were abolished by treatment with a subtype nonselective alpha2-agonist and antagonist. Thus, drugs acting via alpha2C-ARs might have therapeutic value in disorders associated with enhanced startle responses and sensorimotor gating deficits, such as schizophrenia, attention deficit disorder, post-traumatic stress disorder, and drug withdrawal.
Issues & trends affecting the nation's hospices. (1997)

As the hospice industry has grown and moved from isolation into the health care system, it necessarily faces new issues. Some are definite, such as budget considerations; others are more theoretical--for instance, physician-assisted suicide--and thus may remain up for debate as hospice matures into an as-yet-unseen status.
Scale-up of hepatic progenitor cells from multitray stack to 2-D bioreactors (2013)

Promethera Biosciences (Mont-St-Guibert, BE) is developing cell therapies to treat several liver genetic metabolic diseases, such as the Crigler-Najjar syndrome. Human heterologous adult liver progenitors cells (HHALPCs) were initially cultivated in 2D standard cultivation devices. The present study is investigating the feasibility to cultivate HHALPCs in Xpansion bioreactors, with the following objectives:

➢ The process must be closed

➢ The growth rate and population-doubling level (i.e. the number of times the cells in the population has doubled) must be at least equivalent to the current process in multilayer trays

➢ The process must comply to the cGMP rules

➢ The cells must succeed the quality control (QC) test specifications at the end of cultivation, i.e. cells must remain undifferentiated and show the presence of HHAPLCs markers, while exhibiting the capacity to differentiate toward functional hepatocytes.

Integrity® Xpansion™ multiplate bioreactors have been specifically designed to enable an easy transfer from existing multiple-tray-stack processes by offering the same cell growth environment on 2-D hydrophylized Polystyrene (PS) plates in a fully closed system. To make the bioreactors compact, the headspace between each plate has been reduced to a minimum (1.3 mm). Gas transfer is made through a semi-permeable silicone tubing mounted in the central column. Additionally, critical cell culture parameters such as pH and DO are controlled and the cell density is automatically monitored via a specific holographic microscope developed by Ovizio
Strategies for Quality CAD PDKs (2008)

The competitiveness in the industry to provide quick turn around collateral without compromising quality is a necessity. In addition globalization of engineering activities adds their own challenges and a new dimension to ensuring high quality in a short amount of time. This necessity has given rise to new techniques and strategies. In this paper we discuss some of what we have utilized and learnt in our work with respect to continuously enhancing quality while reducing cycle time.
Desgin and comparative study of some sequential jump detection algorithms for digital signals (1983)

The purpose of this paper is to analyze the behavior of several jump detection algorithms when applied to the same real data (geophysical signals) and to compare these algorithms from different points of view: complexity, efficiency, robustness, and ability to characterize the detected jumps. Three types of algorithms are investigated: "filtered derivatives" detectors, cumulative sum (cusum) tests, and Willsky's generalized likelihood ratio (GLR) algorithm. A modified version of this last test is elaborated, and a new detector, mixing GLR and cusum tests, is presented.
Constant Envelope OFDM with Channel Coding (2006)

This paper studies the application of convolutional coding to constant envelope orthogonal frequency division multiplexing (CE-OFDM). The noise at the output of the phase demodulator (in the CE-OFDM receiver) is shown to be approximately Gaussian at high SNR and relatively low modulation indices. This allows the use of the conventional metric in the Viterbi decoding algorithm. A bound on the performance of convolutionally coded CE-OFDM is derived and is plotted along side the performance curves obtained through simulation. Both the cases with and without a phase unwrapper are studied. The phase unwrapper results in large bursts of errors at moderate to high modulation indices due to cycle slips. Such burst errors overwhelm the convolutional code and render it useless. Fewer burst errors are generated in the absence of a phase unwrapper. Further adding a simple interleaver is beneficial to counter the burst errors. It is shown that channel coding with interleaving provides good performance for CE-OFDM for low to moderate modulation indices while correcting burst errors due to phase wrapping
Real-time Canonical-angle Views in 3D Virtual Cities (2014)

Virtual city models are useful for navigation planning or the investigation of unknown regions. However, existing rendering systems often fail to provide optimal views during the exploration, introduce occlusions, or show the buildings from the top only, which limits the amount of useful visual information accessible to the user. In consequence, users are forced to interact more extensively with the application to avoid these shortcomings. This process can be quite time-consuming. In this paper, we propose a new technique based on canonical views to address these problems. We compute every building's canonical view and, dynamically, transform it correspondingly, so that it is easy to identify under all camera angles. A user study was conducted to assess how this technique compares to a regular view; our method improves the recognizability of the buildings and helps the users explore the virtual city more efficiently. The results indicate that using canonical views is beneficial for efficient navigation in virtual cities.
[Treatment of chronic gastritis with traditional Chinese medicine--yingwei tablet]. (1992)

A prospective controlled study on the treatment of 60 cases chronic gastritis with TCM Yingwei tablet as well as Sucrafati and Doperidone tablets from Oct. 1990 to Sep. 1991 were done. 30 patients in each group. The cases in treated group took Yingwei tablet while that in control group took Sucrafati and Doperidone tablets. Before and after treatment, the patients were examined by gastroscope, pathology and Helicobacter pylori. The results showed that total effective rate, the gastroscopically effective rate, the pathological cure rate, the cure rate of gastric mucosa atrophy and the effective rate of bacteriocidal effect against Helicobacter pylori in treated group and control group was 96.7% and 73.3%; 80% and 70%; 36.7% and 20%; 38% and 9%; 60% and 23.0%, respectively, all of the above-mentioned differences between the two groups was significant (P < 0.05-0.01). Therefore Yingwei tablet is an effective drug for various kind of chronic gastritis.
Discovering representative episodal association rules from event sequences using frequent closed episode sets and event constraints (2002)

Discovering association rules from time-series data is an important data mining problem. The number of potential rules grows quickly as the number of items in the antecedent grows. It is therefore difficult for an expert to analyze the rules and identify the useful. An approach for generating representative association rules for transactions that uses only a subset of the set of frequent itemsets called frequent closed itemsets was presented by Saquer and Deogun (2000). We employ formal concept analysis to develop the notion of frequent closed episodes. The concept of representative association rules is formalized in the context of event sequences. Applying constraints to target highly, significant rules further reduces the number of rules. Our approach results in a significant reduction of the number of rules generated, while maintaining the minimum set of relevant association rules and retaining the ability to generate the entire set of association rules with respect to the given constraints. We show how our method can be used to discover associations in a drought risk management decision support system and use multiple climatology datasets related to automated weather stations.
Detection and Identification of Android Malware Based on Information Flow Monitoring (2015)

Information flow monitoring has been mostly used to detect privacy leaks. In a previous work, we showed that they can also be used to characterize Android malware behaviours and in the current one we show that these flows can also be used to detect and identify Android malware. The characterization consists in computing automatically System Flow Graphs that describe how a malware disseminates its data in the system. In the current work, we propose a method that uses these SFG-based malware profile to detect the execution of Android malware by monitoring the information flows they cause in the system. We evaluated our method by monitoring the execution of 39 malware samples and 70 non malicious applications. Our results show that our approach detected the execution of all the malware samples and did not raise any false alerts for the 70 non malicious applications.
Effects of 4-Methylcatechol on Skin Reinnervation: Promotion of Cutaneous Nerve Regeneration After Crush Injury (2009)

We assessed the effects of treatment with 4-methylcatechol (4MC), a known inducer of nerve growth factor, on peripheral nerve regeneration by analyzing cutaneous and muscular reinnervation in mice after sciatic nerve crush injury. At 3 months postinjury, the skin innervation index was significantly higher in the 4MC group than the control group (p=0.0002); there was also increased unmyelinated fiber density (p=0.0042) and unmyelinated fibers/Remak bundle (p = 0.001) in sural nerves, indicating unmyelinated nerve fiber regeneration. These changes were accompanied by increases of transcripts for nerve growth factor (p = 0.0026) and glial cell line-derived neurotrophic factor (p=0.03) in the 4MC group. In contrast, muscle innervation indices were similar in both groups and were higher than the skin innervation index (p < 0.0001). The regeneration of myelinated nerve fibers, as assessed by fiber density, diameter and g ratio analyses in sural nerves, and amplitudes of muscle action potential in sciatic nerves, was similar in both groups. Taken together, these data suggest that 4MC specifically promoted the regeneration of unmyelinated nerve fibers and reinnervation of the skin by increasing the expression of nerve growth factor and glial cell line-derived neurotrophic factor.
A Top-K Keyword Search for Supporting Semantics in Relational Databases (2008)

为了增强关系数据库中的关键字搜索查询结果,考虑了多表之间以及元组之间的语义关系,提出了一种语义评分函数.该语义评分函数不仅涵盖了当前的评分思想,并且加入新指标来衡量查询结果与查询关键字之间的相关性.基于该评分函数,提出两种以数据块为处理单位的Top-K搜索算法,分别为BA(blocking algorithm)算法和EBA(early-stopping blocking algorithm)算法.EBA在BA基础上引入了过滤域值,以便尽早终止算法的迭代次数.最后实验结果显示语义评分函数保证了;In order to enhance the search results of keyword search in relational databases, semantic relationship among relations and tuples is employed and a semantic ranking function is proposed. In addition to considering current ranking principles, the proposed semantic ranking function provides new metrics to measure query relevance. Based on it, two Top-k search algorithms BA (blocking algorithm) and EBA (early-stopping blocking algorithm) are presented. EBA improves BA by providing a filtering threshold to terminate iterations as early as possible. Finally, experimental results show the semantic ranking function guarantees a search result with high precision and recall, and the proposed BA and EBA algorithms improve query performance of existing approaches.
Transparent and visible light-insensitive acrylic photoresist for negative tone optical lithography (2016)

The study presented in this paper describes an optimized negative tone optical resist based on ultraviolet (UV)-induced cross-linking of polymethyl methacrylate (PMMA). This simple resist is made by dissolving PMMA and a photo-cross-linking agent—Irgacure 379, in ethyl lactate. Irgacure cross-links PMMA when exposed to i-line radiation (365 nm wavelength). However, as it does not absorb at longer wavelengths, this resist is in-sensitive to visible light. The outstanding optical transparency and high resolution capability of PMMA make this resist system useful for many applications. While PMMA has low resistance to erosion during dry etching processes, this resist allows plasma erosion resistance to be enhanced by a postpatterning blanket UV exposure process. Furthermore, being based on PMMA and similar acrylic polymers that are amenable to patterning through electron beam lithography, this resist system can also be used for processes that combine optical and electron beam lithography on the same resist film.
First clinical (phase 1b/2a) study of iberdomide (CC-220; IBER), a CELMoD, in combination with dexamethasone (DEX) in patients (pts) with relapsed/refractory multiple myeloma (RRMM). (2019)

8006 Background: IBER is a novel cereblon E3 ligase modulator (CELMoD) with enhanced tumoricidal and immunostimulatory activities. Preclinically, IBER overcomes immunomodulatory drug (IMiD) resistance and has synergy with daratumumab (DARA), bortezomib (BORT), and DEX. Methods: A phase 1b/2a multicenter, open-label, dose-escalation study evaluated the maximum tolerated dose (MTD), recommended phase 2 dose (RP2D), safety, and preliminary efficacy of IBER. Eligible pts had RRMM and must have received ≥ 2 prior regimens including lenalidomide (LEN) and/or pomalidomide (POM), and a proteasome inhibitor (PI). All pts had progressed on or within 60 days of last MM therapy. Escalating doses of IBER were given on days 1–21, in combination with DEX 40 mg (20 mg in pts age > 75 years) on days 1, 8, 15, and 22, of each 28-day cycle. Dose escalation was reviewed by a dose escalation committee. Results: As of Jan 2019,58 pts received IBER + DEX. Median age was 64.5 years (range 33–79), and median number of prior regimens was 5 (2–12). Prior therapies included autologous stem cell transplant (79%), LEN (100%), POM (69%), PIs (100%), and DARA (66%). IBER dose ranged from 0.3 to 1.2 mg; MTD/RP2D was not reached. Median duration of therapy was 12+ weeks (range 4–109). Grade 3–4 adverse events (AEs) were reported in 41 (72%) pts and were not related to dose. Grade 3–4 neutropenia, thrombocytopenia, neuropathy, and fatigue occurred in 26%, 11%, 2%, and 0% pts, respectively. Three pts discontinued treatment due to AEs. Clinical activity occurred early and was observed across all dose levels (Table); 20 of 51 pts remain on treatment (2–27+ cycles). Conclusions: IBER + DEX showed favorable efficacy and safety in heavily pretreated pts with RRMM who failed multiple prior therapies. This study is ongoing, including combinations of IBER with DARA or BORT. Clinical trial information: NCT02773030. [Table: see text]
Role of the vasodilator peptide angiotensin-(1–7) in cardiovascular drug therapy-0 (2011)

The renin-angiotensin-system (RAS) is a cascade of enzymatic reactions resulting ultimately in the formation of angiotensin II. Recent research has expanded the knowledge about the RAS by adding new components to the pathways: angiotensin-(1-5) [Ang-1-5], angiotensin-(1-7) [Ang-(1-7)], angiotensin-(1-9) [Ang-(1-9)], an ACE homologous enzyme, ACE2, and the G-protein-coupled receptor mas as a molecular receptor for Ang-(1-7). Although previous studies provided some conflicting evidence about the relevance of Ang-(1-7) in the regulation of vascular and renal function, data now demonstrate that Ang-(1-7) contributes to the cardiovascular effects of ACE-inhibitors (ACE-1) and AT1-receptor-blockers (ARBs) both in experimental conditions and in humans. This review summarizes and critically discusses the currently available experimental and clinical study evidence for the role of Ang-(1-7) as a vasodilator and anti-trophic peptide in cardiovascular drug therapy. In addition, the potential therapeutic impact of currently available RAS blocking agents (ACE-1 and ARBs) and new agents still under development (renin-inhibitors) on the RAS-effector peptides is highlighted.
REVIEWS (1987)

Journal Article REVIEWS Get access JOSEP PADRò I PARCERISA, Egyptian-Type Documents from the Mediterranean Littoral of the Iberian Peninsula before the Roman Conquest III: Andalusia (=EPRO 65), Leiden, 1985. Pp. 160, 80 plates. J. D. RAY J. D. RAY UNIVERSITY OF CAMBRIDGE Search for other works by this author on: Oxford Academic Google Scholar Journal of Semitic Studies, Volume XXXII, Issue 1, SPRING 1987, Pages 189–190, https://doi.org/10.1093/jss/XXXII.1.189 Published: 01 March 1987
BDD-based logic synthesis for LUT-based FPGAs (2002)

Contemporary FPGA synthesis is a multiphase process that involves technology-independent logic optimization followed by FPGA-specific mapping to a target FPGA technology. Conventional technology-independent transformations target standard cells and are unable to optimize circuits with constraints and goals specific to FPGA architectures. This article describes an FPGA-specific logic synthesis approach, which unites multilevel logic transformation, decomposition, and optimization techniques into a single synthesis framework. This system performs network transformation, decomposition, and optimization at an early stage to generate a network that can be directly mapped onto FPGAs. Our techniques are built upon a BDD-based logic decomposition system. With this system, both AND-OR decompositions and AND-XOR decompositions can be identified, resulting in large area savings for synthesized XOR-intensive circuits. To induce good decompositions, a maximum fanout free cone (MFFC) -based partial clustering and collapsing technique is used. This step is followed by an area-minimizing variable partitioning heuristic that decomposes collapsed nodes into LUT-feasible subfunctions. As a postprocessing step, a performance-driven resynthesis phase is performed to alleviate increased delay caused by excessive logic sharing. We compare the quality of results obtained using our techniques with those of academic (BoolMap, SIS) and industry (Altera Quartus) FPGA synthesis tools. Experimental results indicate that the circuits generated by our techniques are not only smaller, but are also significantly faster than those synthesized by conventional FPGA synthesis tools. Furthermore, the computation times required by our techniques are significantly smaller than those of previous techniques.
d‐Limonene exposure to humans by inhalation: Uptake, distribution, elimination, and effects on the pulmonary function (1993)

The toxicokinetics of d-limonene were studied in human volunteers exposed by inhalation (2 h, work load 50 W) in an exposure chamber on three different occasions. The exposure concentrations were approximately 10, 225, and 450 mg/m3 d-limonene. The relative pulmonary uptake was high, approximately 70% of the amount supplied. The blood clearance of d-limonene observed in this study, 1.1 l kg-1 h-1, indicates that d-limonene is metabolized readily. About 1% of the total uptake was eliminated unchanged in the expired air after the end of exposure, while approximately 0.003% was eliminated in the urine. A long half-time in blood was observed in the slow elimination phase, which indicates accumulation in adipose tissues. A decrease in vital capacity was observed after exposure to d-limonene at a high exposure level. The subjects did not experience any irritative symptoms or symptoms related to the central nervous system (CNS).
Texture Synthesis with Recurrent Variational Auto-Encoder (2017)

We propose a recurrent variational auto-encoder for texture synthesis. A novel loss function, FLTBNK, is used for training the texture synthesizer. It is rotational and partially color invariant loss function. Unlike L2 loss, FLTBNK explicitly models the correlation of color intensity between pixels. Our texture synthesizer generates neighboring tiles to expand a sample texture and is evaluated using various texture patterns from Describable Textures Dataset (DTD). We perform both quantitative and qualitative experiments with various loss functions to evaluate the performance of our proposed loss function (FLTBNK) --- a mini-human subject study is used for the qualitative evaluation.
Design of the Annular Suspension and Pointing System (ASPS) (including design addendum) (1980)

The Annular Suspension and Pointing System is an experiment pointing mount designed for extremely precise 3 axis orientation of shuttle experiments. It utilizes actively controlled magnetic bearing to provide noncontacting vernier pointing and translational isolation of the experiment. The design of the system is presented and analyzed.