gebhart/patrepeval huggingface dataset:
OPERATING SYSTEMS TECHNIQUES FOR PARALLEL COMPUTATION IN INTELLIGENT MEMORY (2002)

Advances in DRAM density have led to several proposals to perform computation in memory [1] [2] [3]. Active Pages is a page-based model of intelligent memory that can exploit large amounts of parallel computation in data-intensive applications. With a simple VLIW processor embedded near each page on DRAM, Active Page memory systems achieve up to 1000X speedups over conventional memory systems [4]. Active Pages are specifically designed to support virtualized hardware resources. In this study, we examine operating system techniques that allow Active Page memories to share, or multiplex, embedded VLIW processors across multiple physical Active Pages. We explore the trade-off between individual page-processor performance and page-level multiplexing. We find that hardware costs of computational logic can be reduced from 31% of DRAM chip area to 12%, through multiplexing, without significant loss in performance. Furthermore, manufacturing defects that disable up to 50% of the page processors can be tolerated through efficient resource allocation and associative multiplexing.
Behavior of Evaporated Palladium Catalyst for Electroless Nickel‐Phosphorus Film Formation (1985)

Vacuum‐evaporated palladium was used as catalyst for electroless Ni‐P deposition on polyimide and alumina substrates. The effect that varying amounts of Pd had on the early stages of electroless plating was investigated by means of Rutherford backscattering spectrometry and transmission electron microscopy. No significant diffusion of the catalyst into the Ni‐P film was observed; in some cases, a small amount of Pd tended to diffuse into the deposited Ni‐P film, particularly on polyimide substrates. The deposition rate of the Ni‐P film on polyimide was always less than that on alumina. An increased amount of catalyst decreased the deposition rate significantly without altering the stoichiometry of the plated film. When less than 1016 Pd at./cm2 were evaporated onto the substrate, the catalyst formed clusters of palladium particles on the surface, whereas larger amounts of Pd (e.g., ) settled as a continuous film at the substrate.
Regioselective Arene Halogenation using the FAD‐Dependent Halogenase RebH (2013)

Gemeinsam geht es leichter: Coexpression der Halogenase RebH mit GroEL/ES sowie Fusion der Flavinreduktase RebF an MBP ermöglichten die Produktion beider Enzyme in Mengen, die für die präparative regioselektive oxidative Halogenierung von Arenen ausreichen. Bezüglich Aktivität und Selektivität übertrifft RebH die strukturell homologe Halogenase PrnA, die nichtnatürliche Substrate nur an ihren elektronisch aktiviertesten Positionen halogenieren kann.
The utility of the Cambridge Behavioural Inventory in neurodegenerative disease (2007)

We investigated the utility of the Cambridge Behavioural Inventory (CBI), a carer-completed questionnaire, in a large cohort with Parkinson's disease (PD) (n = 215). In a sub-cohort of 112 patients with PD, the CBI was found to be a valid instrument compared with the Neuropsychiatric Inventory, PDQ-39 and UPDRS, with high internal consistency. Furthermore, in the whole cohort, the CBI was sensitive to changes in behaviour with disease progression. Comparison between CBI scores in PD and other neurodegenerative diseases, including Huntington's disease (HD) (n = 75), Alzheimer's disease (AD) (n = 96) and frontal variant frontotemporal dementia (fvFTD) (n = 64), revealed distinct profiles for each disease. Predominant deficits were "sleep"' and "self care" in PD; "memory" in HD and AD; and "motivation" and "stereotypic behaviours" in fvFTD. The CBI is a robust, easy-to-use and valid instrument, which has the capacity to discriminate between neurodegenerative diseases, and may be of value in monitoring therapeutic interventions.
Alcohol and illicit drugs among subjects involved in road crashes in Florence, Italy (2009)

A collaborative study was performed in a period of time of 18 months in order to determine the prevalence of alcohol and other drugs (cannabinoids, opiates, cocaine, methadone and amphetamine) in 554 samples both urine and blood from people involved in vehicle crashes and admitted to an Emergency Department.
Identification of a Ca2(+)-dependent cell-cell adhesion molecule in endothelial cells. (1990)

Confluent cultures of aortic endothelial cells contain two different cell-cell adhesion mechanisms distinguished by their requirement for calcium during trypsinization and adhesion. A hybridoma clone was isolated producing a monoclonal antibody Ec6C10, which inhibits Ca2(+)-dependent adhesion of endothelial cells. There was no inhibition of Ca2(+)-independent adhesion of endothelial cells and only a minor effect on Ca2(+)-dependent adhesion of smooth muscle cells. Immunoblotting analysis shows that the antibody Ec6C10 recognizes a protein in endothelial but not epithelial cells with an apparent molecular weight of 135,000 in reducing conditions and 130,000 in non-reducing conditions. Monoclonal antibody Ec6C10 reacts with an antigen at the cell surface as shown by indirect immunofluorescence of confluent endothelial cells in a junctional pattern outlining the cobblestone morphology of the monolayer. Removal of extracellular calcium increased the susceptibility of the antigen recognized by antibody Ec6C10 to proteolysis by trypsin. The role of the Ca2(+)-dependent cell adhesion molecule in organization of the dense peripheral microfilament band in confluent endothelial cells was examined by adjusting the level of extracellular calcium to modulate cell-cell contact. Addition of the monoclonal antibody Ec6C10 at the time of the calcium switch inhibited the extent of formation of the peripheral F-actin band. These results suggest an association between cell-cell contact and the peripheral F-actin band potentially through the Ca2(+)-dependent CAM.
The Effect of Precipitator Types on the Synthesis of La <sub>2</sub> Zr <sub>2</sub> O <sub>7</sub> Powders by Chemical Coprecipitation Method (2010)

This chapter contains sections titled: Introduction Experimental Results and Discussion Conclusions
Mapping Chromatin Interactions by Chromosome Conformation Capture (2006)

Chromosome conformation capture (3C) is one of the only techniques that allows for analysis of an intermediate level of chromosome structure ranging from a few to hundreds of kilobases, a level most relevant for gene regulation. The 3C technique is used to detect physical interactions between sequence elements that are located on the same or on different chromosomes. For instance, physical interactions between distant enhancers and target genes can be measured. The 3C assay uses formaldehyde cross-linking to trap connections between chromatin segments that can, after a number of manipulations, be detected by PCR. This unit describes detailed protocols for performing 3C with yeast Saccharomyces cerevisiae and mammalian cells.
Expression of E-Cadherin and α-Catenin in the Process of Mouse Embryo Implantation (2003)

Purpose Present study was conducted to characterize the expression and distribution of polypeptides encoding cadherin/α?catenin in the endometrium of early pregnany mice. Methods Immunocytochemistry and Immuno-blot methods were used. Results Immunocytochemistry revealed α?cateinin distributed around the glandular epithelial cell margin in the normal and d1-d5 endometrium of pregnant mice.On d6 and d7 α?catenin became restricted to the decidual cells.Altered expression of E?cadherin and α?catenin was observed in the process of mouse implantation,the peak expression both on the d4 of pregnancy (4 hours before implantation). Conclusions Cadherin/α?catenin are involving in the process of embryo implantation.
Structure-function relationship of islet-activating protein pertussis toxin: biological activities of hybrid toxins reconstituted from native and methylated subunits (1986)

Islet-activating protein (IAP), pertussis toxin, is a hexameric protein composed of an A protomer and a B oligomer, the residual pentamer having such a subunit assembly that two different dimers, dimer 1 and dimer 2, are connected with each other by means of the smallest C subunit. Incubation of IAP with formaldehyde and pyridine-borane produced the modified toxin in which most of the free amino groups were dimethylated. The methylated and nonmethylated (native) IAP were disintegrated into their respective constituent components, which were then cross combined to reconstitute hybrid toxins with the original hexameric structure. The binding of the B oligomer to the mammalian cell surface via dimer 2 was, but the binding via dimer 1 was not, seriously impaired by methylation of amino groups in the protein. The binding of the B oligomer allowed the A protomer to enter cells and to catalyze ADP-ribosylation of a membrane Mr 41 000 protein. The diverse biological activities of IAP occurring by this mechanism were mimicked by not only methylated IAP but also all hybrid toxins, indicating that the free amino groups in the protein were not essential for the enzyme activity of the A protomer and that the A protomer was able to enter cells if the B oligomer bound to cells "monovalently" via dimer 1. An additional effect of the B oligomer binding, i.e., the direct stimulation, without the transport of the A protomer, of cells leading to mitosis in lymphocytes in vitro or increases in circulating lymphocytes in vivo, was not mimicked by hybrid toxins containing methylated dimer 2.(ABSTRACT TRUNCATED AT 250 WORDS)
Preparation of a Crosslinking Cassava Starch Adhesive and its Application in Coating Paper (2013)

A new starch-based adhesive with high solid content, high binding force, and low viscosity was prepared via hydrolysis of cassava starch with α-amylase using glycerol as a plasticizer and Ammonium Zirconium Carbonate (AZC) as a crosslinker. The adhesive was applied to coated paper as a partial substitute for SBR latex. The effects of α-amylase, glycerol, AZC, and temperature on the starch adhesive and its performance in application were investigated. The prepared crosslinking cassava starch adhesive showed a significant effect when the starch slurry concentration was 50% (w/w), the dosages of glycerol and α-amylase were 15% and 0.075%, respectively, and the enzymolysis starch was crosslinked with 12% AZC at 50 °C. The modified starch improved the paper in terms of surface strength, gloss, whiteness, and smoothness when 20% SBR latex was substituted into the coating formulation. Statistical analysis indicated that the crosslinking temperature and AZC had significant effects on the performance of the paper, while glycerin and α-amylase had little effect on it. Spectral analysis of the product showed that the crosslinking reaction took place between AZC and cassava starch. The average particle size was 528.6 nm. Scanning Electron Microscope (SEM) images of the paper surface were consistent with the other measured surface properties.
The direct synthesis of fluoro-aromatic derivatives of metals and non-metals (1967)

S. C. Cohen, M. L. N. Reddy and A. G. Massey, Chem. Commun. (London), 1967, 451 DOI: 10.1039/C19670000451
Foil Gas Bearing With Compression Springs: Analyses and Experiments (2007)

A new foil gas bearing with spring bumps was constructed, analyzed, and tested. The new foil gas bearing uses a series of compression springs as compliant underlying structures instead of corrugated bump foils. Experiments on the stiffness of the spring bumps show an excellent agreement with an analytical model developed for the spring bumps. Load capacity, structural stiffness, and equivalent viscous damping (and structural loss factor) were measured to demonstrate the feasibility of the new foil bearing. Orbit and coast-down simulations using the calculated stiffness and measured structural loss factor indicate that the damping of underlying structure can suppress the maximum peak at the critical speed very effectively but not the onset of hydrodynamic rotor-bearing instability. However, the damping plays an important role in suppressing the subsynchronous vibrations under limit cycles. The observation is believed to be true with any air foil bearings with different types of elastic foundations.
Estimation of Interwell Connectivity in the Case of Fluctuating Bottomhole Pressures (2008)

Abstract Injection and production rates are often the most readily available data in a waterflood. Yousef and coworkers have shown that these data can be analyzed using a capacitance model (CM) to determine interwell connectivity and provide a tool for waterflood management. Although the existing CM performs well when tested with data from a reservoir simulator and in some field cases, it is less reliable in cases where bottomhole pressures (BHPs) are changing but not measured and/or where producers have been shut in for extended periods. This paper presents two new important developments of the CM to address these shortcomings: the segmented CM and the compensated CM. The segmented CM can be used where BHP data are unknown. The compensated CM overcomes the problem of the requirement to rerun the model after adding a new producer or shutting-in an existing producer. If both BHP changes and shut-in periods occur, both the segmented and compensated CMs can be used simultaneously to construct a single model for a longer period of data. In several simulated cases with fluctuating BHPs, the segmented and compensated CM successfully determined the true interwell coefficients. The conventional CM gives up to 70% error. In a field case, the segmented and compensated CM improved the prediction R2 by 15% compared to the existing CM. In this field example, there is good agreement between seismic impedance and results from the combination of the segmented and compensated CMs. The existing CM, which is a good beginning, requires enhancements to be more versatile. The segmented and compensated CMs will make connectivity estimation more robust because pressure data are often unavailable or human interventions (e.g., work-overs) cause the flow rates to vary. Adapting the CM to tolerate BHP changes and shut-in wells, as we have done, provides this versatility.
Adsorbed Polyelectrolyte Coatings Decrease Fe<sup>0</sup> Nanoparticle Reactivity with TCE in Water: Conceptual Model and Mechanisms (2009)

The surfaces of reactive nanoscale zerovalent iron (NZVI) particles used for in situ groundwater remediation are modified with polymers or polyelectrolytes to enhance colloidal stability and mobility in the subsurface. However, surface modification decreases NZVI reactivity. Here, the TCE dechlorination rate and reaction products are measured as a function of adsorbed polyelectrolyte mass for three commercially available polyelectrolytes used for NZVI surface modification including poly(styrene sulfonate) (PSS), carboxymethyl cellulose (CMC), and polyaspartate (PAP). The adsorbed mass, extended layer thickness, and TCE-polyelectrolyte partition coefficient are measured and used to explain the effect of adsorbed polyelectrolyte on NZVI reactivity. For all modifiers, the dechlorination rate constant decreased nonlinearly with increasing surface excess, with a maximum of a 24-fold decrease in reactivity. The TCE dechlorination pathways were not affected. Consistent with Scheutjens-Fleer theory for homopolymer adsorption, the nonlinear relationship between the dechlorination rate and the surface excess of adsorbed polyelectrolyte suggests that adsorbed polyelectrolyte decreases reactivity primarily by blocking reactive surface sites at low surface excess where they adsorb relatively flat onto the NZVI surface, and by a combination of site blocking and decreasing the aqueous TCE concentration at the NZVI surface due to partitioning of TCE to adsorbed polyelectrolytes. This explanation is also consistent with the effect of adsorbed polyelectrolyte on acetylene formation. This conceptual model should apply to other medium and high molecular weight polymeric surface modifiers on nanoparticles, and potentially to adsorbed natural organic matter.
Gene Therapy Using TRAIL-Secreting Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells against Intracranial Glioma (2008)

Adenovirus-mediated gene therapies against brain tumors have been limited by the difficulty in tracking glioma cells infiltrating the brain parenchyma. Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSC) are particularly attractive cells for clinical use in cell-based therapies. In the present study, we evaluated the tumor targeting properties and antitumor effects of UCB-MSCs as gene delivery vehicles for glioma therapy. We efficiently engineered UCB-MSCs to deliver a secretable trimeric form of tumor necrosis factor-related apoptosis-inducing ligand (stTRAIL) via adenoviral transduction mediated by cell-permeable peptides. We then confirmed the migratory capacity of engineered UCB-MSCs toward tumor cells by an in vitro migration assay and by in vivo injection of UCB-MSCs into the tumor mass or the opposite hemisphere of established human glioma in nude mice. Moreover, in vitro coculture, experiments on Transwell plates, and in vivo survival experiments showed that MSC-based stTRAIL gene delivery has more therapeutic efficacy compared with direct injection of adenovirus encoding the stTRAIL gene into a tumor mass. In vivo efficacy experiments showed that intratumoral injection of engineered UCB-MSCs (MSCs-stTRAIL) significantly inhibited tumor growth and prolonged the survival of glioma-bearing mice compared with controls. These results suggest that human UCB-MSCs have potential use as effective delivery vehicles for therapeutic genes in the treatment of intracranial glioma.
Two Anti-Reflective Coatings For Use Over Highly Reflective Topography (1985)

Two anti-reflective coatings have been developed which eliminate linewidth variation of HPR-204 and HX-256 over stepped highly reflective topography. These anti-reflective coatings are composed of non-photoactive modified polyimides and laser dyes. Thin coatings exhibit the following desirable properties; strong absorption of 436nm light, the ability to dry etch, resistance to flow at 200°C, and good planarization properties.
Modeling charge self-trapping in wide-gap dielectrics: Localization problem in local density functionals (2003)

We discuss the adiabatic self-trapping of small polarons within the density-functional theory. In particular, we carried out plane-wave pseudopotential calculations of the triplet exciton in NaCl and found no energy minimum corresponding to the self-trapped exciton contrary to the experimental evidence and previous calculations. To explore the origin of this problem we modeled the self-trapped hole in NaCl using hybrid density functionals and an embedded-cluster method. Calculations show that the stability of the self-trapped state of the hole drastically depends on the amount of the exact exchange in the density functional: at less than 30% of the Hartree-Fock exchange, only delocalized hole is stable, at 50%---both delocalized and self-trapped states are stable, while further increase of exact exchange results in only the self-trapped state being stable. We argue that the main contributions to the self-trapping energy such as the kinetic energy of the localizing charge, the chemical bond formation of the dihalogen quasimolecule, and the lattice polarization, are represented incorrectly within the Kohn-Sham based approaches.
β-Relaxation governs protein stability in sugar-glass matrices (2012)

The stabilizing effect of sugar-glass matrix materials for freeze-drying proteins or nucleic acids has been variously ascribed to the thermodynamic effect of ‘water replacement’ by sugar molecules or to the kinetic effect of slowed α relaxation associated with sugar matrix vitrification. While evidence for each of these hypotheses exists, we show that neither can adequately account for the observed stabilization of proteins embedded in sugar-glasses. Instead, we find firm evidence that protein stability in these glasses is directly linked to high frequency β relaxation processes of the sugar matrix. Specifically, we observe that when the β relaxation time, τβ, of sugar-glasses is increased with antiplasticizing additives, protein stability increases in linear proportion to the increase in τβ, even though these same additives simultaneously decrease the glass transition temperature, Tg, and the α relaxation time, τα, of the sugar matrix materials. Moreover, we find that while sugars ‘replace’ water by stabilizing protein native-like conformation in the dry state, the resulting enhanced protein conformational stability does not have a significant impact on the degradation rate of the proteins in sugar-glasses. We discuss implications of these findings for the fundamental physics of glass formation and for effective engineering of protein stabilizing glasses through the modification of τβ.
Continuous flow high field nuclear magnetic resonance detector for liquid chromatographic analysis of fuel samples (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTContinuous flow high field nuclear magnetic resonance detector for liquid chromatographic analysis of fuel samplesJames F. Haw, T. E. Glass, and H. C. DornCite this: Anal. Chem. 1981, 53, 14, 2327–2332Publication Date (Print):December 1, 1981Publication History Published online1 May 2002Published inissue 1 December 1981https://pubs.acs.org/doi/10.1021/ac00237a045https://doi.org/10.1021/ac00237a045research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Receptor (CD46) modulation and complement-mediated lysis of uninfected cells after contact with measles virus-infected cells (1996)

Recently, it has been observed that the infection of human target cells with certain measles virus (MV) strains leads to the downregulation of the major MV receptor CD46. Here we report that CD46 downregulation can be rapidly induced in uninfected cells after surface contact with MV particles or MV-infected cells. Receptor modulation is detectable after 30 min of cocultivation of uninfected cells with MV-infected cells and is complete after 2 to 4 h, a time after which newly synthesized MV hemagglutinin (MV-H) cannot be detected in freshly infected target cells. This contact-mediated receptor modulation is also induced by recombinant MV-H expressed by vaccinia virus and is inhibitable with antibodies against CD46 and MV-H. By titrating the effect with MV Edmonston strain-infected cells, a significant contact-mediated CD46 modulation was detectable up to a ratio of 1 infected to 64 uninfected cells. As a result of CD46 downregulation, an increased susceptibility of uninfected cells for complement-mediated lysis was observed. This phenomenon, however, is MV strain dependent, as observed for the downregulation of CD46 after MV infection. These data suggest that in acute measles or following measles vaccination, uninfected cells might also be destroyed by complement after contacting an MV-infected cell.