gebhart/patrepeval huggingface dataset:
Monoclonal Antibodies Specific for<i>Neisseria meningitidis</i>Group B Polysaccharide and Their Peptide Mimotopes (2001)

From five mice immunized with Escherichia coli K1 bacteria, we produced 12 immunoglobulin M hybridomas secreting monoclonal antibodies (MAbs) that bind to Neisseria meningitidis group B (NMGB). The 12 MAbs also bound the capsular polysaccharide (PS) of E. coli K1 [which, like NMGB, is alpha(2-8)-linked polysialic acid (PSA)] and bound to EV36, a nonpathogenic E. coli K-12 strain producing alpha(2-8) PSA. Except for HmenB5, which cross-reacted with N. meningitidis group C, none of the MAbs bound to N. meningitidis groups A, C, and Y. Of the 12 MAbs, 6 were autoantibodies as defined by binding to CHP-134, a neuroblastoma cell line expressing short-chain alpha(2-8) PSA; five of these MAbs killed NMGB in the presence of rabbit complement, and two also killed NMGB with human complement. The other six MAbs, however, were nonautoreactive; all killed NMGB with rabbit complement, and five killed NMGB with human complement. To obtain peptide mimotopes of NMGB PS, four of the nonautoreactive MAbs (HmenB2, HmenB3, HmenB13, and HmenB14) were used to screen two types of phage libraries, one with a linear peptide of 7 amino acids and the other with a circular peptide of 7 amino acids inserted between two linked cysteines. We obtained 86 phage clones that bound to the screening MAb in the absence but not in the presence of E. coli K1 PSA in solution. The clones contained 31 linear and 4 circular mimotopes expressing unique sequences. These mimotopes nonrandomly expressed amino acids and were different from previously described mimotopes for NMGB PS. The new mimotopes may be useful in producing a vaccine(s) capable of eliciting anti-NMGB antibodies not reactive with neuronal tissue.
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon (1992)

The expression patterns of 13 GABAA receptor subunit encoding genes (alpha 1-alpha 6, beta 1-beta 3, gamma 1-gamma 3, delta) were determined in adult rat brain by in situ hybridization. Each mRNA displayed a unique distribution, ranging from ubiquitous (alpha 1 mRNA) to narrowly confined (alpha 6 mRNA was present only in cerebellar granule cells). Some neuronal populations coexpressed large numbers of subunit mRNAs, whereas in others only a few GABAA receptor-specific mRNAs were found. Neocortex, hippocampus, and caudate-putamen displayed complex expression patterns, and these areas probably contain a large diversity of GABAA receptors. In many areas, a consistent coexpression was observed for alpha 1 and beta 2 mRNAs, which often colocalized with gamma 2 mRNA. The alpha 1 beta 2 combination was abundant in olfactory bulb, globus pallidus, inferior colliculus, substantia nigra pars reticulata, globus pallidus, zona incerta, subthalamic nucleus, medial septum, and cerebellum. Colocalization was also apparent for the alpha 2 and beta 3 mRNAs, and these predominated in areas such as amygdala and hypothalamus. The alpha 3 mRNA occurred in layers V and VI of neocortex and in the reticular thalamic nucleus. In much of the forebrain, with the exception of hippocampal pyramidal cells, the alpha 4 and delta transcripts appeared to codistribute. In thalamic nuclei, the only abundant GABAA receptor mRNAs were those of alpha 1, alpha 4, beta 2, and delta. In the medial geniculate thalamic nucleus, alpha 1, alpha 4, beta 2, delta, and gamma 3 mRNAs were the principal GABAA receptor transcripts. The alpha 5 and beta 1 mRNAs generally colocalized and may encode predominantly hippocampal forms of the GABAA receptor. These anatomical observations support the hypothesis that alpha 1 beta 2 gamma 2 receptors are responsible for benzodiazepine I (BZ I) binding, whereas receptors containing alpha 2, alpha 3, and alpha 5 contribute to subtypes of the BZ II site. Based on significant mismatches between alpha 4/delta and gamma mRNAs, we suggest that in vivo, the alpha 4 subunit contributes to GABAA receptors that lack BZ modulation.
Multi-level IIR digital filters (1986)

A procedure for approximating a multiband response with piecewise-constant magnitude at arbitrary levels is described. The design is based on the use of a cascade of two-level IIR filters. Analytic results are presented for the design of two-level filters at levels <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q</tex> for obtaining equiripple or monotone response, similar to classical filter design. The location of the poles and zeros is derived. The general multiband design can be carried out using numerical procedures. The filter can be configured as a parallel connection of all-pass sections. A multiplicative complementary pair of causal, stable two-level filters using this structure is presented. Multilevel approximation using a cascade of these filters is described.
Cartilage MRI T2 Relaxation Time Mapping: Overview and Applications (2004)

The sensitivity of magnetic resonance imaging to biochemical and biophysical changes in the extracellular matrix of articular cartilage give it the potential to noninvasively detect the earliest changes of cartilage damage. The transverse relaxation time (T2) of cartilage has been shown to be a sensitive parameter for evaluation of early degeneration in articular cartilage, particularly changes in water and collagen content and tissue anisotropy. Although initial application has been in microimaging of small cartilage explants, in vivo techniques have been developed for cartilage T2 mapping of human joints. In addition to potential application in development of new pharmaceuticals and surgical techniques for preserving cartilage, in vivo cartilage T2 mapping can improve understanding of arthritis, cartilage aging, and response of cartilage to exercise.
Assessment of the underlying causes of the immune thrombocytopenia: Ten years experience. (2017)

Immune thrombocytopenia patients have to be evaluated according to their demographic characteristics and laboratory results. Secondary causes of ITP were HIV, HCV, Helicobacter pylori, brucellosis, tuberculosis, and autoimmune diseases in our region. Management of ITP patients can change in different regions.
KARAKTERISTIK HASIL PENGELASAN OXY ASETILIN WELDING (OAW) (2017)

Tujuan dari penelitian ini adalah: Mengetahui elektroda mana yang memiliki hasilpengelasan yang terbaik melalui metode uji tarik. Mengetahui perbedaan komposisi elektroda daribeberapa jenis elektroda dengan pengujian SEM. Mengetahui hubungan antara komposisi elektrodadengan hasil pengelasan dari beberapa jenis elektroda.Spesifikasi benda uji yang digunakan dalam eksperimen ini adalah sebagai berikut: Bahanyang digunakan adalah plat baja kontruksi. Ketebalan plat 3 mm. Elektroda yang digunakan adalahtiga jenis E6013 dengan diameter 3,2 mm. Yang digunakan hanya kawat intinya saja sedangkanfluksnya(coating)dibuang. Menggunakan nyala api netral. Menggunakan sambungan butt (butt joint).Kesimpulan yang dapat diambil dari penelitian ini adalah: Komposisi kawat inti elektroda Aadalah O 19,13%, Na 2,59 %, Al 1,67%, Si 5,66% dan Fe 70,95%. Komposisi fluks elektroda A adalahC 28,89%, O 48,02%, Na 8,80%, Al 1,69%, Si 5,25%, K 1,47%, Ca 2,80%, Ti 1,16% dan Fe 1,91%.Hasil pemeriksaan visual pada pengelasan yang menggunakan variansi kawat pengisi terdapat cacatlas yaitu weaving fault, surface porosity, undercutting. Elektroda A memiliki kekuatan tarik lebih tinggijika dibandingkan dengan elektroda B dan C.
Development of novel CXCR4-based therapeutics (2012)

Development of CXCR4 antagonists with increased affinity, extended pharmacokinetics and/or pharmacodynamics and with the capacity to differentially target CXCR4 may lead to a development of novel therapeutics for HIV, cancer, tissue regeneration and stem cell collection.
Polycystic Ovary Syndrome and Weight Management (2010)

Polycystic ovary syndrome (PCOS) is a common condition in women of reproductive age, and has reproductive, metabolic and psychological implications. Weight gain and obesity worsen the features of PCOS, while weight loss improves the features of PCOS. While there are potential barriers to successful weight management in young women who do not suffer from PCOS, women with PCOS may experience additional barriers. Weight management strategies in younger women with or without PCOS should encompass both the prevention of excess weight gain and achieving and maintaining a reduced weight through multidisciplinary lifestyle management, comprising dietary, exercise and behavioral therapy, as well as attention to psychosocial stress and practical and physiological barriers to weight management. Further research is warranted in the examination of specific barriers to weight management in women with PCOS, as well as in the determination of optimal components of lifestyle weight management interventions in young women in order to facilitate long-term compliance.
[Advances or separation and analytical techniques in proteomic studies]. (2009)

The separation and analytical technique is one of the core technologies in proteomic studies. The advances in the applications of separation and analytical techniques in proteomic studies on protein expression profiling, protein modification profiling, protein complex and interaction network as well as proteome quantitation are reviewed, and 89 references are cited.
Frequency-domain analysis of strongly nonlinear circuits using a consistent large-signal model (1996)

This paper describes an analysis method that extends the applicability of the frequency-domain methods to strongly nonlinear circuits. Nonlinearities are described with Chebyshev expansions which are evaluated with a numerically stable three-term recurrence formula. The method is coupled with a novel, measurement-based consistent modeling approach which allows improved accuracy in describing the frequency-dependence of the measured small-signal parameters. The analysis method and the modeling approach are verified by comparing measurements and calculations on a MESFET mixer, driven with two and three tones.
Phosphate Prodrugs Derived from <i>N</i>-Acetylglucosamine Have Enhanced Chondroprotective Activity in Explant Cultures and Represent a New Lead in Antiosteoarthritis Drug Discovery (2008)

We report the application of the phosphoramidate ProTide approach, developed by us for antiviral nucleosides, to sugar derivatives with potential chondroprotection against osteoarthritis. In particular, N-acetylglucosamine was converted to a series of 06 arylaminoacyl phosphoramidates with ester and amino acid variation. Compounds were prepared by two routes, with or without sugar protection, and were isolated as phosphate diastereoisomers. The compounds were assayed for cellular toxicity and for inhibition of IL-1 induced glycosaminoglycan (GAG) release (i.e., proteoglycan degradation) from bovine articular cartilage in vitro explant cultures. By comparison to the N-acetyl glucosamine parent, some of the analogues show a significant enhancement in efficacy in the inhibition of inflammatory cytokine-induced proteoglycan degradation.
A rule-based decision subsystem design approach for intelligent robot (2009)

A rule-based forward reference approach was proposed for the decision subsystem of the intelligent robot to avoid the complex decision logic and difficulties in improving the performance of the heuristic direct control solutions and to decrease the response time of machine-learning based intelligent approaches. The performance of this rule-based approach can be enhanced by modifying and improving the knowledge base only due to the characteristic that knowledge and control logic are separate and independent of each other in knowledge based system. Moreover, ldquoprimitive actionrdquo, ldquopriority of parallel conclusionrdquo, ldquoparallel search methodrdquo and ldquosimple conflict resolution methodrdquo were also introduced to shorten the system's response time. The successful prototype application in robot soccer verified its effectiveness.
Damping of subsynchronous oscillations and improve transient stability for wind farms (2011)

This paper investigates the application of STATCOM to stabilize the torsional oscillations of sub-synchronous resonance (SSR) of a wind energy conversion system (WECS). The IEEE system-1 of the second benchmark model for computer simulation of subsynchronous resonance is adopted with integrating aggregated induction generator-based wind turbine to perform the study. A small signal analysis is conducted to study the impact of the series compensation levels and torsional dynamics on system stability. EMTDC/PSCAD is used to simulate the system under study. Due to its simplicity, robustness and ease of implementation, a proportional integral (PI) controller along with auxiliary feedback signals are used to control the inverter firing angle to control the reactive power exchange between the AC system and the STATCOM. The performance of the controller is tested in steady state as well as transient conditions.
The Effect of Salinity and Temperature upon the Dissociation of Cresol Red and Phenol Red in Sea Water (1936)

Journal Article The Effect of Salinity and Temperature upon the Dissociation of Cresol Red and Phenol Red in Sea Water Get access Philip H. Mitchell, Philip H. Mitchell Biological Laboratory of Brown University, Providence, R. I., and the Woods Hole Oceanographic InstitutionWoods Hole, Mass Search for other works by this author on: Oxford Academic Google Scholar Kurt Buch, Kurt Buch Biological Laboratory of Brown University, Providence, R. I., and the Woods Hole Oceanographic InstitutionWoods Hole, Mass Search for other works by this author on: Oxford Academic Google Scholar Norris W. Rakestraw Norris W. Rakestraw Biological Laboratory of Brown University, Providence, R. I., and the Woods Hole Oceanographic InstitutionWoods Hole, Mass Search for other works by this author on: Oxford Academic Google Scholar ICES Journal of Marine Science, Volume 11, Issue 2, August 1936, Pages 183–189, https://doi.org/10.1093/icesjms/11.2.183 Published: 01 August 1936
The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer (2009)

The p38 MAPK plays an important role in key cellular processes related to inflammation and cancer. Understanding the signal transduction mechanisms and gene regulation by p38 MAPK provides useful information in the development of p38 MAPK inhibitors with therapeutic benefits with reduced side effects. In this review, we summarize and present the list of p38 MAPK inhibitors in in vitro/in vivo studies as well as in clinical trials.
CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients (2009)

Our findings demonstrate independent effects of CYP2A6 and UGT2B7 genetic variation on efavirenz disposition beyond that of the CYP2B6 polymorphisms. The development and testing of a pharmacogenetic algorithm for estimating the appropriate dose of efavirenz should incorporate genotypic data from both the oxidative and glucuronidation pathways.
Clay and DOPA Containing Polyelectrolyte Multilayer Film for Imparting Anticorrosion Properties to Galvanized Steel (2011)

A facile and green approach is developed to impart remarkable protection against corrosion to galvanized steel. A protecting multilayer film is formed by alternating the deposition of a polycation bearing catechol groups, used as corrosion inhibitors, with clay that induces barrier properties. This coating does not affect the esthetical aspect of the surface and does not release any toxic molecules in the environment.
Nanomolar Heparin Detection with an Artificial Enzyme (2008)

Detecting heparin: We report a new fluorescent approach to the detection and quantification of the biologically relevant molecule heparin. We designed and prepared a cyclic peptide that is able to catalyse the hydrolysis of a fluorogenic anionic ester (green) under low-concentration conditions. Then we demonstrated that the inhibition of this artificial enzyme (grey) by heparin (red) allows its fluorescent sensing with a remarkable sensitivity of 13 nM.
Sonic Hedgehog Is a Novel Tubule-Derived Growth Factor for Interstitial Fibroblasts after Kidney Injury (2014)

Tubular epithelium constitutes the majority of the renal parenchyma and is the primary target of various kidney injuries. However, how the injured tubules drive interstitial fibroblast activation and proliferation remains poorly understood. Here, we investigated the role of sonic hedgehog (Shh), a secreted extracellular signaling protein, in fibroblast proliferation. Shh was induced in renal tubular epithelia in animal models of CKD induced by ischemia/reperfusion injury (IRI), adriamycin, or renal mass ablation, and in renal tubules of kidney biopsy specimens from CKD patients with different etiologies. Using Gli1-CreER(T2) reporter mice, we identified interstitial fibroblasts as the principal targets of renal Shh signaling in vivo. In vitro, incubation with Shh promoted normal rat kidney fibroblast proliferation, which was assessed by cell counting, MTT assay, and BrdU incorporation assay, and stimulated the induction of numerous proliferation-related genes. However, Shh had no effect on the proliferation of renal tubular epithelial cells. In vivo, overexpression of Shh promoted fibroblast expansion and aggravated kidney fibrotic lesions after IRI. Correspondingly, blockade of Shh signaling by cyclopamine, a small molecule inhibitor of Smoothened, inhibited fibroblast proliferation, reduced myofibroblast accumulation, and attenuated renal fibrosis. These studies identify Shh as a novel, specific, and potent tubule-derived growth factor that promotes interstitial fibroblast proliferation and activation. Our data also suggest that blockade of Shh signaling is a plausible strategy for therapeutic intervention of renal fibrosis.
The radiologic diagnosis of complications following gynecologic surgery: radiography, computed tomography, sonography, and scintigraphy. (1984)

673,000 hysterectomies were done in the United States in 1981. The mortality rate of 16.4/100,000 was less than that for appendectomy. Gynecologic surgery, however, is the most common surgical cause of complications related to the urinary tract with the reported incidence varying from less than 1 to 10%. We reviewed the charts of 1403 patients who had 736 abdominal, 315 vaginal and 143 radical or modified radical hysterectomies. Seventy (5%) patients had complications. Thirty-two (2.2%) patients had 35 complications related to the urinary tract. Complications directly related to surgery were grouped into ureteral injuries (13), fistulas (10), post surgical fluid collections (13), and hydronephrosis following radical hysterectomy. Characteristic images obtained by radiography, sonography (US), computed tomography (CT), and nuclear medicine (NM) are presented, and their use in each group of complications is summarized in the conclusion.
Quartermaster - a resource utility system (2005)

Utility computing is envisioned as the future of enterprise IT environments. Achieving utility computing is a daunting task, because enterprise users have diverse and complex needs. In this paper we describe quartermaster, an integrated set of tools that addresses some of these needs. Quartermaster supports the entire lifecycle of computing tasks - including design, deployment, operation, and decommissioning of each task. Although individual components of this lifecycle have been addressed in earlier work, quartermaster integrates them in a unified framework using model-based automation. All tools within quartermaster are integrated using models based on the common information model (CIM), an industry-standard model from the distributed management task force (DMTF). The paper discusses the quartermaster implementation, and describes two case studies using quartermaster.
Chemistry of penicillin (1947)

F. A. Robinson, Analyst, 1947, 72, 274 DOI: 10.1039/AN9477200274
Hardware-in-the-Loop Simulation of Self-Driving Electric Vehicles by Dynamic Path Planning and Model Predictive Control (2021)

This paper applies a dynamic path planning and model predictive control (MPC) to simulate self-driving and parking for an electric van on a hardware-in-the-loop (HiL) platform. The hardware platform is a simulator which consists of an electric power steering system, accelerator and brake pedals, and an Nvidia drive PX2 with a robot operating system (ROS). The vehicle dynamics model, sensors, controller, and test field map are virtually built with the PreScan simulation platform. Both manual and autonomous driving modes can be simulated, and a graphic user interface allows a test driver to select a target parking space on a display screen. Three scenarios are demonstrated: forward parking, reverse parking, and obstacle avoidance. When the vehicle perceives an obstacle, the map is updated and the route is adaptively planned. The effectiveness of the proposed MPC is verified in experiments and proved to be superior to a traditional proportional–integral–derivative controller with regards to safety, energy-saving, comfort, and agility.
Sinterability of Nano-Sized Silicon Carbide Powders (2006)

The sinterability of three kinds of commercially available nano-sized SiC powders and a treated nano-sized SiC powder was investigated using Al2O3-Y2O3-CaO as a sintering additive. The commercially available, as-received nano-sized SiC powders were difficult to sinter to a relative density of >95% by conventional hot pressing. The effects of the free carbon and SiO2 impurities in the starting powders on the sinterability of the nano-sized SiC powders were identical to those on the submicron SiC powders. However, both the extremely high free carbon content and low green density of the commercially available nano-sized SiC powders were responsible for their poor sinterability. The reduction of the free carbon content by oxidation and the control of the SiO2 content by acid treatment were beneficial for enhancing the sinterability of the nano-sized SiC powder during liquid-phase sintering.
Amantadine hydrochloride treatment in heredodegenerative ataxias: a double blind study. (1996)

The rationale of AH use in heredodegenerative ataxias can be explained by its replacement effect (dopamine release) and by direct involvement of N-methyl-D-aspartate (NMDA) in glutamate mediated neurotoxicity in cerebellar granular cells; memantine, an AH analogue, is a potent blocker of NMDA receptors.
Anemic necrosis of the liver after umbilical vein catheterization. (1979)

We report 22 cases of hepatic necrosis following catheterization of the umbilical vein. The morphology of the necrotic lesions, which were confined to the left lobe in 21 patients, was that of an anemic infarct. Their causes are multiple and include intimal damage during the insertion of the catheter with consecutive thrombosis of portal vein branches, the postpartum immaturity of the arterial hepatic oxygen supply, postpartum hypoxia due to respiratory failure of cerebral or pulmonary origin, obstruction of portal venous flow through the catheter as such, the postpartum involution of the left hepatic lobe, and prolonged periods of catheterization. Toxic damage of the hepatic parenchyma due to an infusion of Tris buffer through the catheter into the portal venous system is a potential additional factor.