gebhart/patrepeval huggingface dataset:
Wireless Sensor Networks (2004)

Like any sentient organism, the smart environment relies first and foremost on sensory data from the real world. Sensory data comes from multiple sensors of different modalities in distributed locations. The smart environment needs information about its surroundings as well as about its internal workings; this is captured in biological systems by the distinction between exteroceptors and proprioceptors. The study of wireless sensor networks is challenging in that it requires an enormous breadth of knowledge from an enormous variety of disciplines. In this chapter we outline communication networks, wireless sensor networks and smart sensors, physical transduction principles, commercially available wireless sensor systems, self-organization, signal processing and decision-making, and finally some concepts for home automation.
Effects of birch pollen‐specific immunotherapy on apple allergy in birch pollen‐hypersensitive patients (1998)

SIT with birch pollen extracts effectively reduces clinical apple sensitivity and skin reactivity in most cases after only 1 year of treatment; these effects are not paralleled by a similar reduction in apple-specific IgE. These findings suggest a decrease in activability of effector cells as the mechanism underlying clinical benefit.
Paint and Coatings Technology for the Control of Marine Fouling (2009)

This chapter contains sections titled: Introduction Biocidal Antifouling Paints Non-biocidal Coatings Paint Selection – Economic Considerations Future Perspectives Conclusions References
The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice (2012)

Acute lung injury (ALI) is an inflammatory condition culminating in respiratory failure. There is currently no effective pharmacological treatment. Nitrated fatty acids (NFAs) have been shown to exert anti-inflammatory effects. We therefore hypothesized that delivery of NFAs directly to the site of inflammation would reduce the severity of ALI. Pulmonary delivery of 10-nitro-oleate following endotoxin-induced ALI in mice reduced markers of lung inflammation and injury, including capillary leakage, lung edema, infiltration of neutrophils into the lung, and oxidant stress, as well as plasma levels of proinflammatory cytokines. Nitro-oleate delivery likewise downregulated expression of proinflammatory genes by alveolar macrophages, key cells in regulation of lung inflammation. These effects may be accounted for by the observed increases in the activity of PPAR-γ and the PPAR-γ-induced antioxidant transcription factor Nrf2, together with the decreased activity of NF-κB. Our results demonstrate that pulmonary delivery of NFAs reduces severity of acute lung injury and suggest potential utility of these molecules in other inflammatory lung diseases.
Photoreaction of 2-Halo-<i>N</i>-pyridinylbenzamide:  Intramolecular Cyclization Mechanism of Phenyl Radical Assisted with n-Complexation of Chlorine Radical (2001)

The photochemical behavior of 2-halo-N-pyridinylbenzamide (1-4 in Chart 1) was studied. The photoreaction of 2-chloro-N-pyridinylbenzamides 1a, 2a, 3a, and 4 afforded photocyclized products, benzo[c]naphthyridinones (6-9 and 16), in high yield, whereas the bromo analogues 1b, 2b, and 3b produced extensively photoreduced products, N-pyridinylbenzamides (1c, 10, and 11), with minor photocyclized product. Since the photocyclization reaction of 2-chloro-N-pyridinylbenzamide is retarded by the presence of oxygen and sensitized by the presence of a triplet sensitizer, acetone or acetophenone, a triplet state of the chloro analogue is involved in the reaction. Since several radical intermediates, particularly n-complexes of chlorine radical, are identified in the laser flash photolysis of 2-chloro-N-pyridinylbenzamide, an intramolecular cyclization mechanism of phenyl radical assisted with n-complexation of chlorine radical for the cyclization reaction is proposed: the triplet state (78 kcal/mol) of the chloro analogue (1a), which is populated by the excitation of 1a undergoes a homolytic cleavage of the C-Cl bond to give phenyl and chlorine radicals; while chlorine radical holds the neighbor pyridinyl ring with its n-complexation, the intramolecular arylation of the phenyl radical with the pyridinyl ring proceeds to produce a conjugated 2,3-dihydropyridinyl radical and then the conjugated radical aromatizes to afford a cyclized product, benzo[c]naphthyridinone by ejecting a hydrogen. The photoreduction product can be formed by hydrogen atom abstraction of the phenyl sigma radical from the environment.
Isolation of Highly Purified and Stable Preparations of c-src and v-src Kinase (1991)

We describe here a simple method of purification of src kinase from insect cells infected with a baculovirus expressing c-src kinase or v-src kinase. After two affinity columns prepared with random synthetic polypeptides, highly purified protein tyrosine kinases were obtained that remained active for many months of storage at –70°C.
The substitutability of brands (1999)

A behavior analytical interpretation of consumer brand choice is proposed. The brands studied are of fast-moving consumer goods (FMCG) which are functionally substitutable but differentiated by marketing activity (‘branding’). If functional equivalence was the sole basis of brand substitutability, consumers would either practice single brand purchasing or allocate purchases approximately indifferently (and approximately equally) among competing brands. Brand shares would tend at equilibrium toward equal size. But consumers typically buy several brands of those available, while brand shares vary markedly. The observed patterns of consumer choice are consistent with the predictions of matching theory if brands are assumed to be imperfect substitutes that provide qualitatively different reinforcers. Copyright © 1999 John Wiley & Sons, Ltd.
Delivery of gene silencing agents for breast cancer therapy (2013)

The discovery of RNA interference has opened the door for the development of a new class of cancer therapeutics. Small inhibitory RNA oligos are being designed to specifically suppress expression of proteins that are traditionally considered nondruggable, and microRNAs are being evaluated to exert broad control of gene expression for inhibition of tumor growth. Since most naked molecules are not optimized for in vivo applications, the gene silencing agents need to be packaged into delivery vehicles in order to reach the target tissues as their destinations. Thus, the selection of the right delivery vehicles serves as a crucial step in the development of cancer therapeutics. The current review summarizes the status of gene silencing agents in breast cancer and recent development of candidate cancer drugs in clinical trials. Nanotechnology-based delivery vectors for the formulation and packaging of gene silencing agents are also described.
Ultraflex expandable stents for the management of air leaks. (2006)

Postoperative empyema and aspergillosis were diagnosed in a 66-year-old man. Since non-operative therapy was not effective, we performed surgery. On the 8th postoperative day, a covered Ultraflex expandable stent (Boston Scientific, Galway, Ireland) was implanted to make a one-way airway for blocking a major air leak from a bronchopleural fistula causing respiratory distress. His general condition improved gradually, and he was discharged 30 days after stenting. In conclusion, we used a covered Ultraflex expandable stent to make an airway to block an air leak. This may be a new application for this stent.
Meaning and (F)act: Ray Brassier’s Speculative Nihilism and its Implications for Dialectics (2012)

This paper seeks to frame the proper place for the empirical phenomenon of human meaning in the scientifically disenchanted world described by Ray Brassier. I embrace Brassier’s statement that “Nihilism is not an existential quandary but a speculative opportunity” but disagree with his injunction that human meaning is unimportant. Meaning should be an object of philosophy insofar as we are biologically bound to experiencing the world in a meaningful way. Brassier’s work is exciting for its application of rigorous analytic techniques to continental discourse, in a manner that makes contributions to both metaphysics and philosophy of science.
T helper Type 2 Differentiation is Associated with Induction of Antibacterial Defense Mechanisms in Blood Lymphocytes of Patients with Sarcoidosis (2009)

Whereas sarcoidosis is characterized by an excessive inflammatory immune response mainly at the pulmonary site, circulating T lymphocytes poorly respond to antigen challenge. It has been suggested, that the extensive local inflammation might be triggered by bacterial pathogens. Recently, it has been shown that this paradoxically immunological situation likely results from a disequilibrium between effector and regulatory T lymphocytes (T(reg)). Here, we apply a DNA microarray approach in order to analyze circulating T cells for specific dysregulatory events, which should provide detailed insights in the impairment of cell-mediated immunity. Gene expression profiles were performed from peripheral blood T lymphocytes of untreated patients with pulmonary sarcoidosis (stage I) (n = 3) and a control group consisting of healthy donors (n = 3). Circulating T lymphocytes in sarcoidosis exhibit a specific gene expression pattern of molecules that are primarily involved in immune responses and lymphocyte signalling. Compared to controls patients with sarcoidosis display also alterations in gene expression of molecules with bacteriolytic and chemotactic function. Among others, array analysis resulted in increased transcript levels of Th2 immune response, whereas genes coding for molecules involved in Th1 differentiation are down-regulated. Furthermore, genes encoding proteins representing primordial antimicrobial peptides which may mobilise immunocompetent T cells and other inflammatory cells are up-regulated. This observation supports recent reports suggesting that bacterial antigens play a role in the pathogenesis of sarcoidosis. However, the results of our study indicate an unbalanced immune response towards Th2 in the peripheral blood of patients with sarcoidosis.
Superconductor-semiconductor hybrid devices, circuits, and systems (1989)

The discovery of superconductors whose critical temperatures are above liquid nitrogen temperature has prompted considerable interest in hybrid superconducting-semiconducting electronics applications. The authors review the efforts to hybridize these technologies. Some of these efforts have already been demonstrated on a laboratory scale; others are at present just theoretical proposals. Hybridization is possible on the system, circuit, and device levels. The authors review studies of the applications of superconductors for interconnecting semiconductor systems and combining semiconductor and superconductor devices to enhance the performance of both digital and analog systems. Novel circuit combinations of superconducting and semiconducting devices are mentioned, as are proposals to combine these materials on the device level. It is noted that the use of hybrid combinations may permit some electronic functions to be performed better than either technology could perform separately.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Xanthine Oxidase Inhibitors from the Roots of Eggplant (<i>Solanum Melongena</i>L.) (1993)

Stigmasterol 1, stigmasterol-β-D-glucoside 2, β-sitosterol-β-D-glucoside 3, dioscin 4, protodioscin 5 and methyl protodioscin 6 were isolated and characterized from the butanol soluble part of the ethanolic extract of eggplant roots (Solanum melongena L. Solanaceae). Except for stigmasterol, these compounds have not been previously isolated from Solanum melongena L.Since the roots of the eggplant have been used in folk medicine for rheumatism, inflammation and foot pain1,2, these compounds were tested for their inhibitory effect on xanthine oxidase. The results showed that the phytosterols 1,2 and 3 displayed a stronger inhibition on xanthine oxidase than the steroidal glycosides 4, 5 and 6. From the structural features, the active moiety seems to be the double bond for both phytosterols and steroidal glycosides or 22-OH group in furostanol glycoside 5 as regards xanthine oxidase inhibition based on this study.
El superyó femenino (1999)

Platelet-released growth factors (PRGF) and its related clinically used formulations [e.g. Vivostat platelet-rich fibrin (PRF(®) )] are thrombocyte concentrate lysates that support healing of chronic, hard-to-heal and infected wounds. Human beta-defensin-2 (hBD-2) is an antimicrobial peptide expressed in human keratinocytes exhibiting potent antimicrobial activity against wound-related bacteria. In this study, we analysed the influence of PRGF on hBD-2 expression in human primary keratinocytes and the influence of Vivostat PRF(®) on hBD-2 expression in experimentally generated skin wounds in vivo. Treatment of primary keratinocytes with PRGF caused a significant increase in hBD-2 gene and protein expressions in a concentration- and time-dependent manner. The use of blocking antibodies revealed that the PRGF-mediated hBD-2 induction was partially mediated by the epidermal growth factor receptor and the interleukin-6 receptor (IL-6R). Luciferase gene reporter assays indicated that the hBD-2 induction through PRGF required activation of the transcription factor activator protein 1 (AP-1), but not of NF-kappaB. In concordance with these cell culture data, Vivostat PRF(®) induced hBD-2 expression when applied to experimentally generated skin wounds. Together, our results indicate that the induction of hBD-2 by thrombocyte concentrate lysates can contribute to the observed beneficial effects in the treatment of chronic and infected wounds.
Design and Synthesis of HIF-1 Inhibitors as Anti-cancer Therapeutics (2022)

Cancer is responsible for one fourth of the total deaths and is the second leading cause of death, behind heart disease, in the United States. However, there are as many approaches to curing cancer as there are types of cancer. One important issue in solid tumors is hypoxia, a lack of oxygen, which promotes angiogenesis and anaerobic metabolism, which can increase cancer progression and metastasis. The HIF transcription factor is responsible for the mediation of many processes involved during hypoxia and is linked to poor patient prognosis, increased cancer progression, and invasiveness of tumors. With this in mind, the HIF pathway has become an attractive target for small molecule inhibition. Herein, we describe the design and synthesis of small molecules that inhibit the HIF pathway. These compounds are based off an initial ?hit? compound, KCN-1, from screening of a 10,000 compound library. KCN1 is both highly effective and has a low toxicity profile. Over 200 compounds have been synthesized by the Wang lab, with the best compound IVSR64b having an IC50 of 0.28 ?M. Of special interest is that these compounds do not appear to have any inherent toxicity toward healthy tissues, but only affect cancer cells. Moreover, x-ray crystal structures for both KCN-1 and IVSR64b were obtained and used as the basis for computational modeling, which is still in progress.
On the Degrees-of-Freedom of the K-user Gaussian interference channel (2009)

The degrees-of-freedom of a K-user Gaussian interference channel (GIFC) has been defined to be the multiple of (1/2) log <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> P at which the maximum sum of achievable rates grows with increasing P. In this paper, we establish that the degrees-of-freedom of three or more user, real, scalar GIFCs, viewed as a function of the channel coefficients, is discontinuous at points where all of the coefficients are non-zero rational numbers. More specifically, for all K > 2, we find a class of K-user GIFCs that is dense in the GIFC parameter space for which K/2 degrees-of-freedom are exactly achievable, and we show that the degrees-of-freedom for any GIFC with non-zero rational coefficients is strictly smaller than K/2. These results are proved using new connections with number theory and additive combinatorics.
Entanglement-based quantum communication secured by nonlocal dispersion cancellation (2014)

Quantum key distribution (QKD) enables participants to exchange secret information over long distances with unconditional security. However, the performance of today's QKD systems is subject to hardware limitations, such as those of available nonclassical-light sources and single-photon detectors. By encoding photons in high-dimensional states, the rate of generating secure information under these technical constraints can be maximized. Here, we demonstrate a complete time-energy entanglement-based QKD system with proven security against the broad class of arbitrary collective attacks. The security of the system is based on nonlocal dispersion cancellation between two time-energy entangled photons. This resource-efficient QKD system is implemented at telecommunications wavelength, is suitable for optical fiber and free-space links, and is compatible with wavelength-division multiplexing.
A Review of Strain Analysis Using Electron Backscatter Diffraction (2011)

Since the automation of the electron backscatter diffraction (EBSD) technique, EBSD systems have become commonplace in microscopy facilities within materials science and geology research laboratories around the world. The acceptance of the technique is primarily due to the capability of EBSD to aid the research scientist in understanding the crystallographic aspects of microstructure. There has been considerable interest in using EBSD to quantify strain at the submicron scale. To apply EBSD to the characterization of strain, it is important to understand what is practically possible and the underlying assumptions and limitations. This work reviews the current state of technology in terms of strain analysis using EBSD. First, the effects of both elastic and plastic strain on individual EBSD patterns will be considered. Second, the use of EBSD maps for characterizing plastic strain will be explored. Both the potential of the technique and its limitations will be discussed along with the sensitivity of various calculation and mapping parameters.
IDUA mutational profiling of a cohort of 102 European patients with mucopolysaccharidosis type I: identification and characterization of 35 novel α-L-iduronidase (IDUA) alleles (2011)

Mutational analysis of the IDUA gene was performed in a cohort of 102 European patients with mucopolysaccharidosis type I. A total of 54 distinct mutant IDUA alleles were identified, 34 of which were novel including 12 missense mutations, 2 nonsense mutations, 12 splicing mutations, 5 micro-deletions, 1 micro-duplication 1 translational initiation site mutation, and 1 'no-stop' change (p.X654RextX62). Evidence for the pathological significance of all novel mutations identified was sought by means of a range of methodological approaches, including the assessment of evolutionary conservation, RT-PCR/in vitro splicing analysis, MutPred analysis and visual inspection of the 3D-model of the IDUA protein. Taken together, these data not only demonstrate the remarkable mutational heterogeneity characterizing type 1 mucopolysaccharidosis but also illustrate our increasing ability to make deductions pertaining to the genotype-phenotype relationship in disorders manifesting a high degree of allelic heterogeneity.
Hierarchical Reinforcement Learning and Hidden Markov Models for Task-Oriented Natural Language Generation (2011)

Surface realisation decisions in language generation can be sensitive to a language model, but also to decisions of content selection. We therefore propose the joint optimisation of content selection and surface realisation using Hierarchical Reinforcement Learning (HRL). To this end, we suggest a novel reward function that is induced from human data and is especially suited for surface realisation. It is based on a generation space in the form of a Hidden Markov Model (HMM). Results in terms of task success and human-likeness suggest that our unified approach performs better than greedy or random baselines. 1
Proliferation induced by keratinocyte growth factor enhances in vivo retroviral-mediated gene transfer to mouse hepatocytes. (1996)

Retroviral gene transfer to liver without prior injury has not yet been accomplished. We hypothesized that recombinant human keratinocyte growth factor would stimulate proliferation of hepatocytes and allow for efficient in vivo gene transfer with high titer murine Moloney retroviral vectors. This report shows that 48 h after intravenous injection of keratinocyte growth factor, hepatocyte proliferation increased approximately 40-fold compared to non-stimulated livers. When keratinocyte growth factor treatment was followed by intravenous injection of high titer (1 x 10(8) colony forming units/ml) retrovirus coding for the Escherichia Coli beta-galactosidase gene, there was a 600-fold increase in beta-galactosidase expression, with 2% of hepatocytes transduced. Thus, by exploiting the mitogenic properties of keratinocyte growth factor, retrovirus-mediated gene transfer to liver may be accomplished in vivo without the use of partial hepatectomy or pretreatment with other toxins to induce hepatocyte cell division.
Regulation of human corneal epithelial cell proliferation and apoptosis by dexamethasone. (2000)

To investigate whether human corneal epithelial cells express the glucocorticoid receptor (GR) and to assess the influence of dexamethasone (DEX) on these cells.Human corneal epithelial cells were cultured in medium supplemented with various concentrations of DEX (ranging from 10(-10) to 10(-4) M). Cell proliferation was analyzed by 3-(4, 5-dimethylthiazol-2-yl)-5-(3-carboxy-methoxyphenyl)-2-(4-sulfop henyl) -2H-tetrazolium inner salt (MTS) assay at 2, 4, and 6 days of culture. Apoptosis was studied by nucleus labeling using a fluorescent dye and immunostaining by APO 2.7 at 6 days of culture. GR mRNA was detected in corneal epithelium and cultured corneal epithelial cells by means of reverse transcription-polymerase chain reaction (RT-PCR). Immunocytochemical staining of the epithelial cells was performed with a monoclonal anti-human GR.RT-PCR and immunocytochemistry showed the expression of GR (mRNA and protein) in corneal epithelial cells. DEX significantly increased corneal epithelial cell proliferation with concentrations ranging from 10(-10) to 10(-6) M, with a maximum effect at 10(-7) M (P < 0.005). However, DEX also induced apoptosis of cultured corneal epithelial cells at any concentration used.These results indicate that human corneal epithelial cells express the GR and proliferate in response to DEX stimulation which also induces corneal epithelial cell apoptosis.
Dynamic of lead speciation in sewage sludge composting (2004)

A large-scale sewage sludge composting experiment was conducted to develop an understanding of changes that occur to Pb chemical speciation, distribution and bio-availability during the course of composting. The four-stage Tessier sequential extraction method was employed to investigate the dynamics of heavy metal Pb speciation (exchangeable, bound to carbonates, bound to Fe-Mn oxides, bound to organic matter and sulphides, residual) during the course of sewage sludge composting. The concentrations of the total Pb and the five Pb fractions concentrations were increased during the whole stage of compost. However, the percentages of Pb distribution with respect to total Pb were changed in the following manner: exchangeable, bound to Fe-Mn oxides and bound to carbonates Pb with respect to total Pb were increased, while the percentages of bound to organic matter and sulphides, and residual Pb with respect to total Pb were decreased during composting. The data showed that the quantity of Pb in the less toxic portion, such as consisting of organic matter and sulphides bound and residual Pb, was increased, and that the contamination and bio-availability of heavy metal Pb in sewage sludge was reduced during the composting process.