gebhart/patrepeval huggingface dataset:
Accuracy of uniaxial accelerometer in chronic obstructive pulmonary disease (2008)

Wearable sensors have been developed and used in nondisabled adults. Little is known about their accuracy in patients with chronic disease. We tested the ActiHealth accelerometer, which measures step counts, in subjects with chronic obstructive pulmonary disease (COPD). We determined the intra- and interdevice coefficients of variation (CVs). We assessed the accuracy of the device in 15 nondisabled males and 46 subjects with COPD. Accuracy was defined as percent step capture, (device step count divided by manual step count) times 100. Predictors of percent step capture were identified using linear regression methods. The accelerometer has an intradevice CV ranging from 0.008 to 0.025 and an interdevice CV of 0.64. In nondisabled males, median percent step capture was 96% (interquartile range 81%-98%). In subjects with COPD, median percent step capture was 86% (interquartile range 72%-96%). Usual walking speed was the most important predictor of percent step capture (p = 0.004). The ActiHealth accelerometer has acceptable intra- and interdevice CVs. It is highly accurate in nondisabled subjects. The accuracy declines in subjects with COPD based on walking speed. Prior to using the ActiHealth accelerometer, researchers and clinicians should assess walking speed and percent step capture in each subject.
A Supplemented High-Fat Low-Carbohydrate Diet for the Treatment of Glioblastoma (2015)

We demonstrate that the sHFLC diet is a viable treatment alternative to the KD, and should be considered for clinical testing. Clin Cancer Res; 22(10); 2482-95. ©2015 AACR.
NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure (2013)

The neuronal RNA binding protein NOVA regulates splicing, shuttles to the cytoplasm, and co-localizes with target transcripts in dendrites, suggesting links between splicing and local translation. Here we identified >200 transcripts showing NOVA-dependent changes in abundance, but, surprisingly, HITS-CLIP revealed NOVA binds these RNAs in introns rather than 3' UTRs. This led us to discover NOVA-regulated splicing of cryptic exons within these introns. These exons triggered nonsense mediated decay (NMD), as UPF1 and protein synthesis were required for NOVA's effect on RNA levels. Their regulation was dynamic and physiologically relevant. The NMD exons were regulated by seizures, which also induced changes in Nova subcellular localization and mediated large changes in synaptic proteins, including proteins implicated in familial epilepsy. Moreover, Nova haploinsufficient mice had spontaneous epilepsy. The data reveal a hidden means of dynamic RNA regulation linking electrical activity to splicing and protein output, and of mediating homeostatic excitation/inhibition balance in neurons.DOI:http://dx.doi.org/10.7554/eLife.00178.001.
Relation of inflammatory cytokines to atrial fibrillation after off-pump coronary artery bypass grafting (2006)

Advanced age was a major risk factor for postoperative AF. Furthermore, inflammatory response induced by surgical trauma was also associated with the development of AF after off-pump CABG.
Hysteresis of the ventricular paced QT interval in response to abrupt changes in pacing rate (1988)

The rate of QT adaptation to abrupt changes in pacing rate was studied in seven patients with newly diagnosed complete heart block with a ventricular escape rate of less than 40 beats.min-1. Their median age was 70 (range 36-84) years, and none was taking any cardioactive medication known to affect the QT interval. From a baseline pacing rate of 50 or 110 beats.min-1 the ventricular rate was increased or decreased to a new level. The time taken for the ventricular paced QT interval to complete 90% of the change secondary to the change in rate was found to be 136(16) s (mean(SEM] when the rate was increasing and 189(25) s when the rate was decreasing (p less than 0.01). This time interval was independent of the magnitude of the rate change and the baseline heart rate from which the change occurred. Furthermore, the time course of QT adaptation was found to be exponential and was characterised by a time constant of 49.1(2.2) s when the rate was increasing and 60.4(2.0) s when the rate was decreasing (p less than 0.01). It is concluded that QT measurements in response to a change in pacing rate should take into account the time dependent nature of QT changes.
β-Blocker Therapy and Symptoms of Depression, Fatigue, and Sexual Dysfunction (2002)

The conventional wisdom that beta-blocker therapy is associated with substantial risks of depressive symptoms, fatigue, and sexual dysfunction is not supported by data from clinical trials. There is no significant increased risk of depressive symptoms and only small increased risks of fatigue and sexual dysfunction. The risks of these adverse effects should be put in the context of the documented benefits of these medications.
Detecting Networks Anomalies and Attacks Using 3D Visualization (2015)

3D modeling and visualization has become a key component of scientific research and development in many domains. Adding new routers, switches or firewalls, the computer networks are becoming more and more complex. The paradigm of introducing computer networks in three dimensions helps a lot to protect and provide services to networks. Therefore, the main purpose of this paper is detecting the network anomalies based on a 3D visualization of computer network. The interactivity between network administrator and the application happens in real-time. This means that if a breakdown occurs, the network administrator will be informed in real time and will be able immediately to switch off the broken device and then repair it. Practically, we realized a 3D modeling and visualization of our university computer network with more than thousand devices and it works well.
Finite element modelling and physics of remote field eddy current responses for axially aligned cracks (1992)

A simplified physical model for two-dimensional (2-D) finite element analysis of axially aligned crack responses for the remote field eddy current (RFEC) technique is proposed. Two formulations are applied to model the problems. Reasonable agreement between calculated results and some preliminary experimental results is achieved. A hypothesis, based on the physical model, is presented. It explains the RFEC signals from axially aligned cracks and makes some predictions of possible features for future verification.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Courting of Kume no Zenji : The Allurement of Waka under the Tenji Court (2012)

Explanatory Note : This paper presents an analysis of the "Five poems exchanged in the courting of Ishikawa no Iratsume by Kume no Zenji" (poems 96-100, compiled under the reign of Emperor Tenji) found in the sōmon (poems of courting or dialogic exchange) of the Man'yōshū, Book 2. This representative set of sōmon is centered around the two pillars of the "bow" and the concept of "nochi no kokoro" (opposite of shoshin; the state of enlightenment achieved through accumulated training) and limns their relationship from the man's initial overture, through their romantic acrobatics, and eventuating in wedlock. Within the context of these two pivot words, of particular notice is the name given to the male courter: Kume no Zenji. ……
Power interfaces and storage selection for an ultrafast EV charging station (2012)

The paper is a summary of the research conducted so far on the ultrafast charging issues of electric vehicles with the main emphasis on the infrastructure.In order to estimate the load curve and peaks resulting from high charging rate, simulations are carried out initially to determine energy and power ratings.Energy storage options for filtering out the perspective peaks are discussed with applicable power interfaces between the grid, the vehicle and the storage buffer.Finally, an ultrafast charging architecture based on cascaded H-bridge converters is proposed.
Studies on the Antioxidant Activity of Pomegranate (<i>Punica</i> <i>granatum</i>) Peel and Seed Extracts Using in Vitro Models (2001)

Antioxidant-rich fractions were extracted from pomegranate (Punica granatum) peels and seeds using ethyl acetate, methanol, and water. The extracts were screened for their potential as antioxidants using various in vitro models, such as beta-carotene-linoleate and 1,1-diphenyl-2-picryl hydrazyl (DPPH) model systems. The methanol extract of peels showed 83 and 81% antioxidant activity at 50 ppm using the beta-carotene-linoleate and DPPH model systems, respectively. Similarly, the methanol extract of seeds showed 22.6 and 23.2% antioxidant activity at 100 ppm using the beta-carotene-linoleate and DPPH model systems, respectively. As the methanol extract of pomegranate peel showed the highest antioxidant activity among all of the extracts, it was selected for testing of its effect on lipid peroxidation, hydroxyl radical scavenging activity, and human low-density lipoprotein (LDL) oxidation. The methanol extract showed 56, 58, and 93.7% inhibition using the thiobarbituric acid method, hydroxyl radical scavenging activity, and LDL oxidation, respectively, at 100 ppm. This is the first report on the antioxidant properties of the extracts from pomegranate peel and seeds. Owing to this property, the studies can be further extended to exploit them for their possible application for the preservation of food products as well as their use as health supplements and neutraceuticals.
Therapeutic Blockade of TCR Signal Transduction and Co-Stimulation in Autoimmune Disease (2005)

Autoimmune diseases are initiated and maintained by presentation of self antigen through complex interactions between different cells of the immune system. In most autoimmune disorders, autoantigen-specific responses are induced by the activation of specific T cells with self peptides displayed on activated antigen presenting cells (APCs). These T cells may then activate and drive B cell responses that either initiate or contribute to chronic disease pathogenesis. In order to activate the T cell, two signals are required: T cell receptor (TCR) engagement by autoantigen presented in the context of self MHC class II and costimulation (CD28-CD80/CD86 interactions). Feedback must also be provided to the APC through MHC class II engagement by the TCR and through costimulatory events controlling T cell differentiation and effector function (CD154-CD40 interactions, among others). With this in mind, numerous strategies have been developed to block the engagement and activation of self-reactive cells. We review and discuss recent progress in understanding the efficacy and underlying molecular mechanisms of three separate immunotherapeutic strategies targeting the TCR and costimulatory molecules: i) blocking TCR signaling (using non-mitogenic anti-CD3 monoclonal antibody); ii) blocking CD28 costimulation (anti-B7 monoclonal antibody blockade); and iii) blocking CD40 engagement on APCs (anti-CD154 monoclonal antibody blockade).
Alkali-Silica Reaction Mitigation: State-of-the-Art (2001)

Abstract : This report gathers the state-of-the-art in alkali silica reaction (ASR) in concrete, and ASR mitigation techniques, in preparation for a more detailed study to be submitted to Congress in response to Public Law 106-398 (HR 4205). Mitigation techniques from various states in the U.S., and from various countries and international organizations, were assessed and summarized. A set of recommended mitigation procedures was developed, which is being implemented in the current and upcoming Tri-Service guide specifications on concrete. In particular, the recommended methodology requires the replacement of cement by Class F or N fly ash (25% to 40% by weight), or ground granulated blast furnace slag (GGBFS) Grade 100 or 120 (40% to 50% by weight), or a combination of both. The Class F or N fly ash should also have a maximum of 1.5% available alkali, a maximum 6% loss on ignition, and a maximum of 8% CaO. In addition to mitigating ASR, these cement replacements are expected to: (1) reduce concrete costs, (2) significantly enhance the durability of concrete, (3) increase fly ash and GGBFS recycling, and (4) support the 1997 Kyoto protocol by significantly reducing CO2 production. If 25% of all cement were to be replaced, total savings to the United States economy could be in excess of $1 billion every year.
Whatever happened to the male teacher? Gendered discourses and progressive education in Sweden 1945‐2000 (2004)

In Sweden, as in most western countries, progressive pedagogy has influenced the rhetoric of education policy and national curricula. In the early twentieth century, ideas about learning by doing and pupil centred education came to Sweden from countries such as Germany, Austria and the US. These ideas were primarily influenced by people interested in preschool education, a few persons who started progressive private schools and those who wanted to introduce a more equal and democratic compulsory school system for all children. However, sixty years and two World Wars elapsed before nine‐year co‐educational compulsory schooling, inspired by progressive ideas, was introduced in 1962 in Sweden.
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1 (2009)

To survive in hostile environments, organisms activate stress-responsive transcriptional regulators that coordinately increase production of protective factors. Hypoxia changes cellular metabolism and thus activates redox-sensitive as well as oxygen-dependent signal transducers. We demonstrate that Sirtuin 1 (Sirt1), a redox-sensing deacetylase, selectively stimulates activity of the transcription factor hypoxia-inducible factor 2 alpha (HIF-2alpha) during hypoxia. The effect of Sirt1 on HIF-2alpha required direct interaction of the proteins and intact deacetylase activity of Sirt1. Select lysine residues in HIF-2alpha that are acetylated during hypoxia confer repression of Sirt1 augmentation by small-molecule inhibitors. In cultured cells and mice, decreasing or increasing Sirt1 activity or levels affected expression of the HIF-2alpha target gene erythropoietin accordingly. Thus, Sirt1 promotes HIF-2 signaling during hypoxia and likely other environmental stresses.
Systematics of the vipers of the Caucasus: Polymorphism or sibling species? (1995)

Inter-and intramorphological variation were examined in sympatric and allopatric polymorphic and monomorphic populations of the Vipera ursinii and Vipera kaznakovi complexes.The alpine Vipera dinniki populations in upper Great Caucasus show a pronounced, and to a certain extent geographical, polymorphism.Color patterns include among others 'kaznakovi', 'tigrina', 'berus', 'bronze', and 'ursinii' types.Several of these patterns can be represented within the same litter in certain populations.Vipera dinniki is sympatric with the Caucasian representative of the Vipera ursinii complex in some areas.This last taxon shows a similar degree of polymorphism, which is unique for this complex, and due to morphological and molecular distinction, we consider it to be a Caucasian evolutionary species within the ursinii complex -Vipera lotievi sp.n.
Comparison of Targeted-Gene Replacement Frequencies in <i>Drosophila melanogaster</i> at the <i>forked</i> and <i>white</i> Loci (1996)

P element-induced gene conversion has been previously used to modify the white gene of Drosophila melanogaster in a directed fashion. The applicability of this approach of gene targeting in Drosophila melanogaster, however, has not been analyzed quantitatively for other genes. We took advantage of the P element-induced forked allele, f(hd), which was used as a target, and we constructed a vector containing a modified forked fragment for converting f(hd). Conversion frequencies were analyzed for this locus as well as for an alternative white allele, w(eh812). Combination of both P element-induced mutant genes allowed the simultaneous analysis of conversion frequencies under identical genetic, developmental, and environmental conditions. This paper demonstrates that gene conversion through P element-induced gap repair can be applied with similar success rates at the forked locus and in the white gene. The average conversion frequency at forked was 0.29%, and that at white was 0.17%. These frequencies indicate that in vivo gene targeting in Drosophila melanogaster should be applicable for other genes in this species at manageable rates. We also confirmed the homolog dependence of reversions at the forked locus, indicating that P elements transpose via a cut-and-paste mechanism. In a different experiment, we attempted conversion with a modified forked allele containing the su(Hw) binding site. Despite an increased sample size, there were no conversion events with this template. One interpretation (under investigation) is that the binding of the su(Hw) product prevents double-strand break repair.
Acid-Base Equilibria in Concentrated Salt Solutions. IV. Some Bases of Various Charge Types in Dilute Acid Solutions<sup>1,2</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcid-Base Equilibria in Concentrated Salt Solutions. IV. Some Bases of Various Charge Types in Dilute Acid Solutions1,2Donald Rosenthal, Ignatius T. Oiwa, Augustus D. Saxton, and Louis R. LietoCite this: J. Phys. Chem. 1965, 69, 5, 1588–1595Publication Date (Print):May 1, 1965Publication History Published online1 May 2002Published inissue 1 May 1965https://pubs.acs.org/doi/10.1021/j100889a024https://doi.org/10.1021/j100889a024research-articleACS PublicationsRequest reuse permissionsArticle Views29Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Between- and within-site variability of fMRI localizations (2016)

This study provides first data about the spatial variability of fMRI sensorimotor localizations when investigating the same subjects at different fMRI sites. Results are comparable to a previous patient study. We found a median between-site variability of about 6 mm independent of task (motor or sensory) and experimental standardization (high or low). An intraclass correlation coefficient analysis using data quality measures indicated a major influence of the fMRI site on variability. In accordance with this, within-site localization variability was considerably lower (about 3 mm). We conclude that the fMRI site is a considerable confound for localization of brain activity. However, when performed by experienced clinical fMRI experts, brain pathology does not seem to have a relevant impact on the reliability of fMRI localizations. Hum Brain Mapp 37:2151-2160, 2016. © 2016 Wiley Periodicals, Inc.
Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens (2016)

Although classical, negatively charged antifolates such as methotrexate possess high affinity for the dihydrofolate reductase (DHFR) enzyme, they are unable to penetrate the bacterial cell wall, rendering them poor antibacterial agents. Herein, we report a new class of charged propargyl-linked antifolates that capture some of the key contacts common to the classical antifolates while maintaining the ability to passively diffuse across the bacterial cell wall. Eight synthesized compounds exhibit extraordinary potency against Gram-positive S. aureus with limited toxicity against mammalian cells and good metabolic profile. High resolution crystal structures of two of the compounds reveal extensive interactions between the carboxylate and active site residues through a highly organized water network.
Título en español. (1961)

Dos experimentos de campo para estudiar el efecto de la aplicación de riego a distintas etapas de crecimiento en combinación con tres niveles de nitrógeno en la producción de maíz fueron llevados a cabo en la Subestación de Lajas. Se usaron los siguientes tratamientos de riego: Frecuente, cuando el 20 por ciento del agua asimilable había sido usada; intermedio, cuando el 60 por ciento del agua asimilable había sido usada; y testigo, parcelas sin riego. Además, se les aplicaron riego frecuente a otras parcelas hasta las siguientes etapas de crecimiento: Espigamiento, barba y hasta que el grano estuvo formado y duro (a los 80 días de sembrado), suspendiéndose el riego una vez llegó a su respectiva etapa de crecimiento. En otras parcelas se empezó la aplicación de riego frecuente una vez el maíz llegó a las etapas de crecimiento antes mencionadas, continuándose el riego hasta la cosecha. A estas parcelas, al igual que a las parcelas testigos, se les hizo una aplicación de riego inicial para establecer las plantas. Los niveles de nitrógeno incluidos fueron 0, 60 y 120 libras por acre.
Viscoelastic behavior and order‐disorder transition in mixtures of a block copolymer and a midblock‐associating resin (1988)

Abstract The viscoelastic behavior and order‐disorder transition in mixtures of a block copolymer and a midblock‐associating resin were investigated. The block copolymers investigated were polystyrene‐ block ‐polysioprene‐ block ‐polystyrene (SIS) copolymers (Shell Development Company), specifically Kraton D‐1107, with the block molecular weights 10,000S‐120,000I‐10,000S, and Kraton D‐1111, with the block molecular weights 15,000S‐100,000I‐15,000S. The midblock‐associating resin investigated was a resin polymerized from C 5 hydrocarbon, referred to as Piccotac 95BHT (Hercules Inc.), which is an aliphatic hydrocarbon containing considerable amounts of cyclic structures, with a weight‐average molecular weight of 1,100 and a glass transition temperature T g of 43°C. In the investigation, mixtures of the block copolymer and Piccotac 95BHT were prepared with toluene as solvent. Temperature scans of the samples were made to obtain information on dynamic storage modulus G ′, dynamic loss modulus G ″, and loss tangent tan δ, using a Rheometrics dynamic mechanical spectrometer. It was found that Piccotac 95BHT decreased the plateau modulus G 0 N and increased the T g of the polyisoprene midblock of the SIS block copolymer in the mixture. This experimental observation led to the conclusion that Piccotac 95BHT associates (or is compatible) with the rubbery polyisoprene midblock of the SIS block copolymer. The order‐disorder transition behavior of mixtures of SIS block copolymer and Piccotac 95BHT was also investigated by a rheological technique proposed by Han and Kim (Ref. 21). The order‐disorder transition temperature T r (i.e., the temperature at which the ordered microdomain structure of the block copolymer completely disappears) of the SIS block copolymer decreased steadily with increasing amount of Piccotac 95BHT in the mixture. With the information determined on T r , a phase diagram for the mixture was constructed, showing the boundary between the mesophase and homogeneous phase in the mixture. The phase diagram is in qualitative agreement with the theoretical predictions of Whitmore and Noolandi (Ref. 28).