gebhart/patrepeval huggingface dataset:
Effective Use of Dupilumab in Managing Systemic Allergic Contact Dermatitis (2018)

Allergic contact dermatitis to metals has become increasingly recognized in patients with endovascular implants. The ACD can lead to in-stent restenosis as well as a prominent eczematous reaction overlying the implant, often necessitating its removal. We present a case of refractory allergic contact dermatitis to nickel in a 44-year-old man with numerous endovascular stents and vascular clips. He developed numerous adverse effects of systemic therapy to manage his symptoms including recurrent infections leading to frequent hospitalizations. He was effectively transitioned to dupilumab, a monoclonal antibody against the IL-4α subunit currently approved by the Food and Drug Administration in the management of atopic dermatitis, with an improvement in symptoms and a reduction in infection rate.
Experimental and theoretical studies on inhibition of mild steel corrosion by some synthesized polyurethane tri-block co-polymers (2016)

Polyurethane based tri-block copolymers namely poly(N-vinylpyrrolidone)-b-polyurethane-b-poly(N-vinylpyrrolidone) (PNVP-PU) and poly(dimethylaminoethylmethacrylate)-b-polyurethane-b-poly(dimethylaminoethylmethacrylate) (PDMAEMA-PU) were synthesized through atom transfer radical polymerization (ATRP) mechanism. The synthesized polymers were characterized using nuclear magnetic resonance (NMR) spectroscopy and gel permeation chromatography (GPC) methods. The corrosion inhibition performances of the compounds were investigated on mild steel (MS) in 0.5 M H2SO4 medium using electrochemical measurements, surface analysis, quantum chemical calculations and molecular dynamic simulations (MDS). Potentiodynamic polarization (PDP) measurements revealed that the polymers are mixed-type corrosion inhibitors. Electrochemical impedance spectroscopy (EIS) measurements showed that the polymers inhibit MS corrosion by adsorbing on MS surface to form pseudo-capacitive interface. The inhibitive effects of the polymers increase with increasing concentration and decrease with increasing temperature. The adsorption of both the polymers on MS surface obey the Langmuir adsorption isotherm and involves both physisorption and chemisorption mechanisms. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) analyses showed that the polymers formed protective film on MS surface and shield it from direct acid attack. Quantum chemical calculations and molecular dynamic simulations studies corroborate experimental results.
Call Tree Transformation for Program Obfuscation and Copy Protection (2013)

Abstract. In this paper we propose a new scheme for software obfuscation and license protection that is based on an original transformation of the program’s call tree. The idea is based on the observation of similarities between a program’s call tree and Context Free Grammars. First, this paper proposes a practical technique for applying well studied LALR methodologies to transforming a program’s call tree. Second, we suggest methods of effective binding of the transformed program to the program’s installation site. Finally, we note that the given scheme provides us with a series of difficult to remove unique identifications integrally embedded into the transformed programs that could be used for software watermarking purposes.
Voice-Controlled and Wireless Solid Set Canopy Delivery (VCW-SSCD) System for Mist-Cooling (2018)

California growers in the San Joaquin Valley believe that climate change will affect the pistachio yield dramatically. As the central valley fog disappears, insufficient dormant chill accumulation results in poor flowering synchrony, flower quality, and fruit set in this dioecious species. We have developed a novel, user-friendly, and low-cost Voice-Controlled Wireless Solid Set Canopy Delivery (VCW-SSCD) system to increase bud chill accumulation with evaporative cooling on sunny (winter) days. This system includes: (i) an automated solid-state canopy delivery (SSCD) system; (ii) a wireless weather-, crop-related data acquisition system; (iii) a Voice-Controlled (VC) system using Amazon Alexa; (iv) a mobile application to visualize the collected data and wirelessly control the SSCD system; and (v) a smart control system. The proposed system was deployed and evaluated in a commercial pistachio orchard in Bakersfield, CA. The system worked well with no reported errors. Results demonstrated the system’s ability to cool bud temperatures in a low relative humidity climate. At an ambient temperature of 10–20 °C, bud temperatures were lowered 5–10 °C.
Study of living single cells in culture: automated recognition of cell behavior. (1988)

An automated system capable of analyzing the behavior, in real time, of single living cells in culture, in a noninvasive and nondestructive way, has been developed. A large number of cell positions in single culture dishes were recorded using a computer controlled, robotized microscope. During subsequent observations, binary images obtained from video image analysis of the microscope visual field allowed the identification of the recorded cells. These cells could be revisited automatically every few minutes. Long-term studies of the behavior of cells make possible the analysis of cellular locomotary and mitotic activities as well as determination of cell shape (chosen from a defined library) for several hours or days in a fully automated way with observations spaced up to 30 minutes. Short-term studies of the behavior of cells permit the study, in a semiautomatic way, of acute effects of drugs (5 to 15 minutes) on changes of surface area and length of cells.
The information percolator (1999)

Most current interface designs require that the user focus their attention on them in order to be of value. However, as the price of computation falls, and computational capabilities make their way into many everyday objects, the demand for attention from many different directions may begin to seriously reduce the usefulness of these computational objects. Ambient information displays are intended to fit in a part of the interface design space that does not have this property. They are designed to convey background or context information that the user may or may not wish to attend to at any given time. Ambient Displays are designed to work primarily in the periphery of a user's awareness, moving to the center of attention only when appropriate and desirable. This paper describes a new ambient information display that is designed to give a rich medium of expression placed within an aesthetically pleasing decorative object. This display — the Information Percolator — is formed by air bubbles rising up tubes of water. By properly controlling the release of air, a set of pixels which scroll up the display is created. This allows a rendition of any (small, black and white) image to be displayed. The detailed design and construction of this display device will be considered, along with several applications.
Standardization efforts for wireless LANs (1991)

The Digital European Cordless Telecommunications (DECT) draft standard, which is the only wireless local area network (LAN) standard close to the 1-Mb/s data rate is briefly described. Active standards groups and their activities are reviewed. The work of the IEEE working groups for wireless LANs is examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Linear LIDAR versus Geiger-mode LIDAR: impact on data properties and data quality (2016)

LIDAR has become the inevitable technology to provide accurate 3D data fast and reliably even in adverse measurement situations and harsh environments. It provides highly accurate point clouds with a significant number of additional valuable attributes per point. LIDAR systems based on Geiger-mode avalanche photo diode arrays, also called single photon avalanche photo diode arrays, earlier employed for military applications, now seek to enter the commercial market of 3D data acquisition, advertising higher point acquisition speeds from longer ranges compared to conventional techniques. Publications pointing out the advantages of these new systems refer to the other category of LIDAR as "linear LIDAR", as the prime receiver element for detecting the laser echo pulses - avalanche photo diodes - are used in a linear mode of operation. We analyze the differences between the two LIDAR technologies and the fundamental differences in the data they provide. The limitations imposed by physics on both approaches to LIDAR are also addressed and advantages of linear LIDAR over the photon counting approach are discussed.
A Study of Drag Reduction Devices for Production Pick-up Trucks (2017)

<div class="section abstract"><div class="htmlview paragraph">This paper describes a study of drag reduction devices for production pick-up trucks with a body-on-frame structure using full-scale wind tunnel testing and Computational Fluid Dynamics (CFD) simulations. First, the flow structure around a pick-up truck was investigated and studied, focusing in particular on the flow structure between the cabin and tailgate. It was found that the flow structure around the tailgate was closely related to aerodynamic drag. A low drag flow structure was found by flow analysis, and the separation angle at the roof end was identified as being important to achieve the flow structure. While proceeding with the development of a new production model, a technical issue of the flow structure involving sensitivity to the vehicle velocity was identified in connection with optimization of the roof end shape. (1)A tailgate spoiler was examined for solving this issue. It was shown to be effective on real-world roads where there are corners and crosswinds, based on measurement of yaw dependence of drag reduction by the spoiler. This paper presents a detailed explanation of this issue and how it was resolved, focusing especially on the mechanism and effect of the tailgate spoiler. Furthermore, three additional key aerodynamic devices were examined for reducing drag of body-on-frame pick-up trucks: (2) a front spoiler, (3) frame side deflectors, and (4) rear wheel-house covers. The front spoiler reduces underfloor drag commensurate with the increased air volume for front brake cooling as a result of designing a tunnel-like shape upstream of the front tires. The frame side deflectors reduce drag at the rear wheel-houses by deflecting the flow from outside of the frame beams to the rear wheel-houses. The rear wheel-house covers reduce drag produced at the rear wheelhouses. As a result of adopting these devices with new styling, the new production model achieved a drag coefficient (CD) of 0.37 as measured in Nissan’s wind tunnel, representing a 12% improvement over the previous model. The value is significantly better than that of other competitor vehicles, thereby achieving class-leading aerodynamic performance among the same segment pick-up trucks.</div></div>
Short‐ and long‐term outcomes of canalith repositioning for benign paroxysmal positional vertigo (2000)

This is a prospective, nonrandomized study of the canalith repositioning procedure (CRP) for treatment of benign paroxysmal positional vertigo (BPPV). CRP was used to treat 168 patients with BPPV. Patient data were gathered by yearly telephone interviews to determine whether symptoms of position‐induced vertigo had returned. After 1 or 2 treatment sessions 91.3% of patients reported complete symptom resolution. Average follow‐up for the study population after the initial treatment was 26 months. A recurrence rate of 26.8% was found among those patients who initially reported resolution of symptoms after CRP. Application of recurrence data to a Kaplan‐Meier estimation suggests a 15% recurrence rate per year of BPPV, with a 50% recurrence rate of BPPV at 40 months after treatment. There was no significant association between cure or recurrence rate and sex, age, duration of symptoms, presumed cause, or treating physician.
Flash memory disturbances: modeling and test (2002)

Nonvolatile Memories (NVMs) can undergo different types of disturbances. These disturbances are particular to the technology and the cell structure of the memory element. In this paper we develop a coupling fault model that appropriately models disturbances in flash memories that use floating gate transistor as their core memory element. We describe the behavior of faulty cells under different fault models and how their characteristics change under each model. We demonstrate the inappropriateness of conventional march algorithms for testing flash memories and present a procedure to derive pseudo-algorithms that can be used in testing flash memories. In addition we present an efficient test that detects these disturbances under different fault models developed in this paper.
Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo. (1989)

Experiments were undertaken to demonstrate and partially explain the protective effect of bovine lactoferrin (LB) when administered intravenously to mice 24 h before a challenge with a lethal dose of Escherichia coli. About 70% of mice pretreated with LB survived challenge. The survival rates in control mice treated with E. coli alone and pretreated with bovine serum albumin (BSA), were 4 and 8%, respectively. Human lactoferrin (LH) had almost the same protective effect as LB. Sufficient amounts of ferric ions were given to mice, in single and multiple doses, for full serum transferrin saturation 30 min before or after E. coli administration. The multiple dose of ferric ions did not change considerably the survival rate of mice pretreated with LB. In contrast, a single dose of ferric ions gradually decreased the survival rate of the mice after the first week of experiment. From day 14 this decrease was statistically significant in all groups of mice treated with a single dose of ferric ions when compared with mice pretreated only with LB, and the difference ranged from 25 to 35% on day 30. The possible mechanism(s) of protective effect of LB and role of iron ions are discussed.
Isobutylmethylxanthine Fails to Stimulate Chloride Secretion in Cystic Fibrosis Airway Epithelia (1993)

It has been proposed that a combination of an activated adenylyl cyclase and a high concentration of a phosphodiesterase inhibitor (isobutylmethylxanthine [IBMX], 5 mM) stimulates Cl- secretion mediated by the heterologously expressed cystic fibrosis transmembrane regulator protein carrying the most common cystic fibrosis (CF) mutation (delta F508). We tested whether Cl- secretion could be stimulated by this protocol in vitro and in vivo in CF airway epithelia expressing endogenous delta F508 CFTR protein. In cultured airway preparations, forskolin (a direct adenylyl cyclase activator) stimulated Cl- secretion in amiloride-pretreated normal (delta Isc = 7.1 +/- 1.7 microA.cm-2) but not CF tissues (delta Isc = -02 +/- 0.1 microA.cm-2). Unexpectedly, IBMX partially inhibited the forskolin-induced Cl- secretion in normal tissues; IBMX addition had no effect on CF tissues. Direct measurements of cell cAMP concentrations revealed that 0.1 mM IBMX and forskolin produced the maximum levels of cell cAMP levels attainable with this drug combination, and 5 mM IBMX was without further effect. The combination of forskolin (10(-5) M) and isoproterenol, an adenylyl cyclase activator (10(-5) M), produced approximately 3 times higher levels of cAMP than forskolin/IBMX but also did not induce Cl- secretion in CF tissues. Studies of Cl- secretion in vivo, assessed by the transepithelial electric potential difference (PD), showed that isoproterenol (10(-5) M) stimulated Cl- secretion (delta PD = -16.3 +/- 4.3 mV; n = 4) in nasal epithelia of normal subjects but not in CF patients homozygous for the delta F508 mutation (delta PD = -2.6 +/- 1.9 mV; n = 5).(ABSTRACT TRUNCATED AT 250 WORDS)
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation (2008)

Production of a red blood cell's hemoglobin depends on mitochondrial heme synthesis. However, mature red blood cells are devoid of mitochondria and rely on glycolysis for ATP production. The molecular basis for the selective elimination of mitochondria from mature red blood cells remains controversial. Recent evidence suggests that clearance of both mitochondria and ribosomes, which occurs in reticulocytes following nuclear extrusion, depends on autophagy. Here, we demonstrate that Ulk1, a serine threonine kinase with homology to yeast atg1p, is a critical regulator of mitochondrial and ribosomal clearance during the final stages of erythroid maturation. However, in contrast to the core autophagy genes such as atg5 and atg7, expression of ulk1 is not essential for induction of macroautophagy in response to nutrient deprivation or for survival of newborn mice. Together, these data suggest that the ATG1 homologue, Ulk1, is a component of the selective autophagy machinery that leads to the elimination of organelles in erythroid cells rather that an essential mechanistic component of autophagy.
The Application Of The Robust Discrete Wavelet Transform To Underwater Sound (2000)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
Safety Evaluation of Bifidobacterium lactis BL-99 and Lacticaseibacillus paracasei K56 and ET-22 in vitro and in vivo (2021)

Probiotics have been reported to play a major role in maintaining the balance of microbiota in host. Consumption of food with probiotics has increased with consumer concerns regarding healthy diets and wellness. Correspondingly, safety evaluation of probiotics for human consumption has become increasingly important in food industry. Herein, we aimed to test the safety of <i>Bifidobacterium lactis</i> BL-99 and <i>Lacticaseibacillus paracasei</i> K56 and ET-22 strains <i>in vitro</i> and <i>in vivo</i>. In results, these strains were found to be negative for mucin degradation and platelet aggregation test. Additionally, the three strains were susceptible to eight antibiotics. In accordance with bacterial reversion mutation (Ames) assay, the tested strains had no genetic mutagenicity. Finally, it was confirmed that there were no dose-dependent mortality and toxicity throughout multidose oral toxicity tests in rats. Our findings demonstrated that <i>B. lactis</i> BL-99 and <i>L. paracasei</i> K56 and ET-22 can achieve the generally recognized as safe (GRAS) status as probiotics in the future.
Inflammatory Biomarkers as Differential Predictors of Antidepressant Response (2015)

Although antidepressants are generally effective in the treatment of major depressive disorder (MDD), it can still take weeks before patients feel the full antidepressant effects. Despite the efficacy of standard treatments, approximately two-thirds of patients with MDD fail to respond to pharmacotherapy. Therefore, the identification of blood biomarkers that can predict the treatment response to antidepressants would be highly useful in order to improve this situation. This article discusses inflammatory molecules as predictive biomarkers for antidepressant responses to several classes of antidepressants, including the N-methyl-d-aspartate (NMDA) receptor antagonist ketamine.
Fundamentals of aluminium metallurgy : production, processing and applications (2011)

Introduction to aluminium metallurgy. Part 1 Production and casting of aluminium and its alloys: Production of alumina Production of primary aluminium Production of secondary aluminium Ingot casting and casthouse metallurgy of aluminium and its alloys Casting of aluminium alloys Quality issues in aluminium castings Case studies in aluminium casting alloys High pressure diecasting of aluminium and its alloys Progress on the heat treatment of high pressure diecastings. Part 2 Metallurgical properties of aluminium and its alloys: Work hardening of aluminium alloys Precipitation and solute clustering in aluminium: Advanced characterization techniques Solute partitioning to enhance mechanical properties of aged aluminium alloys Vacancies in aluminium and solute-vacancy interactions in aluminium alloys Modeling the kinetics of precipitation processes in aluminium alloys Ultrafine grained aluminium alloys: Processes, structural features and properties Design for fatigue crack growth resistance in aluminium alloys Fracture resistance in aluminium Corrosion and corrosion protection of aluminium. Part 3 Processing and applications of aluminium and its alloys: Joining of aluminium and its alloys Aluminium powder metallurgy Laser sintering and rapid prototyping of aluminium Aluminium sheet fabrication and processing Application of modern aluminium alloys to aircraft Materials selection and substitution using aluminium alloys.
Temperature-dependent work functions of free alkali-metal nanoparticles (2002)

Photoionization yields have been measured as a function of temperature for the alkali metals Li, Na, and K in the form of free nanometer-sized clusters in a beam. The data can be fitted very well by a finite-temperature Fowler plot, originally derived for bulk surfaces. The resulting temperature-dependent ionization thresholds match precisely the literature work function values and are, within the experimental uncertainties, in agreement with recent theoretical models for thermal shifts of the work function.
Breast cancer chemoprevention: risk-benefit effects of the antioestrogen tamoxifen (2002)

The anti-oestrogen tamoxifen, which is widely used as adjuvant therapy for breast cancer, is undergoing evaluation as a chemopreventive agent in women at increased risk of developing this disease. Recent results from the National Surgical Adjuvant Breast and Bowel Project (NSABP) P-1 prevention trial show a 49% reduction in breast cancer incidence in healthy, high-risk women. However, tamoxifen treatment has the serious side effect of increasing the incidence of endometrial cancer in women and long-term administration of tamoxifen causes hepatic tumours in rats. These liver tumours are induced via a genotoxic mechanism, but the mechanisms responsible for endometrial cancer in women are not yet known and are a focus of much debate. This review describes the findings from the chemoprevention trials and problems associated with the use of tamoxifen in this setting. The mechanism of carcinogenesis in rat liver is explained in detail and compared to the situation in humans, with a view to assessing the risks associated with tamoxifen therapy and predicting whether other anti-oestrogens might be safer alternatives.
Spectral and nonlinear optical properties of fullerene-doped π-conjugated organic systems (2001)

The fullerene-doping effect on spectral and nonlinear optical properties of (pi) -conjugated organic systems based on 2-cyclooctylamino-5-nitropyridine, 2-(n-prolinol)-5- nitropyridine, N-(4-nitrophenyl)-(L)-prolinol, and polyimide 6B has been investigated. Under nanosecond laser irradiation at the wave length of 532 nm, reverse saturable absorption has been examined. To clarify peculiarities of optical laser power limiting, the reverse saturable absorption, the Foerster mechanism, two-photon and free-carrier absorption, as well as the complex formation must be taken into consideration. The compounds investigated have been found to be efficient absorbers and they could be applied to limit the laser irradiation at the energy density of more than 4-5 J/cm<SUP>-2</SUP>.
Sensemble : a wireless inertial sensor system for the interactive dance and collective motion analysis (2006)

Thesis (S.M.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2006.