gebhart/patrepeval huggingface dataset:
The Role of Soluble Aggregates in the Primary Immune Response of Mice to Human Gamma Globulin (1966)

Research Articles| July 17 2009 The Role of Soluble Aggregates in the Primary Immune Response of Mice to Human Gamma Globulin Subject Area: Immunology and Allergy C.N. Gamble C.N. Gamble Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, Calif. Search for other works by this author on: This Site PubMed Google Scholar International Archives of Allergy and Applied Immunology (1966) 30 (5): 446–455. https://doi.org/10.1159/000229829 Article history Published Online: July 17 2009 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation C.N. Gamble; The Role of Soluble Aggregates in the Primary Immune Response of Mice to Human Gamma Globulin. International Archives of Allergy and Applied Immunology 1 May 1966; 30 (5): 446–455. https://doi.org/10.1159/000229829 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsInternational Archives of Allergy and Applied Immunology Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1966Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Effect of substrate absorption on the efficiency of laser patterning of indium tin oxide thin films (1999)

Maskless laser patterning of indium tin oxide thin films for flat panel display applications was studied as a function of wavelength using different harmonics of a diode-pumped Q-switched Nd:YLF laser. Electrically isolating lines could be written at all wavelengths used. However, while lines written at the infrared and the visible wavelengths exhibited a ripplelike morphology due to incomplete material removal, ultraviolet laser irradiation produced residue-free etch lines with superior smoothness even at higher scan speeds. The threshold fluences for material removal at different wavelengths were found to correlate with the optical properties of the indium tin oxide film. In addition, numerical simulations of laser-induced temperature rise yielded peak surface temperatures well above the vaporization temperature of the indium tin oxide film, indicating that, at all wavelengths studied, material removal occurs via thermal vaporization. The calculations also revealed that the absorption of the ultraviolet laser light by the glass substrate is the key factor for the residue-free removal of the indium tin oxide film. Moreover, using a flashlamp-pumped Nd:yttrium-aluminum-garnet laser and a galvanometric scanning system, high process speeds in excess of 1 m/s could be achieved.
Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues (2005)

Extracellular proteases of the matrix metalloproteinase (MMP) and serine protease families participate in many aspects of tumour growth and metastasis. Using quantitative real-time RT-PCR analysis, we have undertaken a comprehensive survey of the expression of these enzymes and of their natural inhibitors in 44 cases of human prostate cancer and 23 benign prostate specimens. We found increased expression of MMP10, 15, 24, 25 and 26, urokinase plasminogen activator-receptor (uPAR) and plasminogen activator inhibitor-1 (PAI1), and the newly characterised serine proteases hepsin and matriptase-1 (MTSP1) in malignant tissue compared to benign prostate tissue. In contrast, there was significantly decreased expression of MMP2 and MMP23, maspin, and the protease inhibitors tissue inhibitor of metalloproteinase 3 (TIMP3), TIMP4 and RECK (reversion-inducing cysteine-rich protein with Kazal motifs) in the cancer specimens. The expression of MMP15 and MMP26 correlated positively with Gleason score, whereas TIMP3, TIMP4 and RECK expression correlated negatively with Gleason score. The cellular localisation of the expression of the deregulated genes was evaluated using primary malignant epithelial and stromal cell cultures derived from radical prostatectomy specimens. MMP10 and 25, hepsin, MTSP1 and maspin showed predominantly epithelial expression, whereas TIMP 3 and 4, RECK, MMP2 and 23, uPAR and PAI1 were produced primarily by stromal cells. These data provide the first comprehensive and quantitative analysis of the expression and localisation of MMPs and their inhibitors in human prostate cancer, leading to the identification of several genes involved in proteolysis as potential prognostic indicators, in particular hepsin, MTSP1, MMP26, PAI1, uPAR, MMP15, TIMP3, TIMP4, maspin and RECK.
Novel solutions to enable contact resistivity <1E-9 Ω-cm<sup>2</sup> for 5nm node and beyond (2018)

In this paper, we present a solution for N&P MOS contact resistivity (p <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ) improvement by adoption of highly doped epitaxial source/drain (S/D), contact ion implantation and advanced laser anneal. An ultra-low ρ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> =3D 9.01×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-10</sup> Ωcm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> on NMOS contact chain (CC) is achieved using highly doped (HD) Si:P selective epi in S/D combined with Ge PAI (pre-amorphization implant) and Applied Materials' nanosecond laser anneal (NLA). In addition, a record low ρ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> =3D 1.16 ×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> Ωcm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for PMOS CC is demonstrated by Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.55</sub> Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">045</sub> :B epi, Ga cryo ion implant and NLA. NLA enables super-activation of implanted dopants and dopants in the in-situ HD S/D epi films ([P]: 3.0-10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">21</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> for NSD epi; [B]: 1.0x10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">21</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> for PSD epi). These new process technologies provide a pathway to achieve the target p <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> required for transistor performance in advanced logic devices.
GaN betavoltaic energy converters (2005)

Semiconductor betavoltaic converters use energy from radioisotope sources to generate electricity for remote applications requiring power for 5-50 years. To be competitive with thermoelectric devices, they must achieve an efficiency above 20%. This paper presents the design rules and efficiency calculations for such high efficiency GaN betavoltaic converters, and experimentally demonstrates the radiation tolerance of GaN.
Determination of Hypoxanthine in Fish Meat with an Enzyme Sensor (1983)

ABSTRACT An enzyme sensor specific for hypoxanthine (Hx) was developed using immobilized xanthine oxidase‐membrane and an oxygen probe. Xanthine oxidase (E.C. 1.2.3.2.) was covalently immobilized on a membrane prepared from cellulose triacetate, 1,8‐diamino‐4‐aminomethyloctane, and glutaraldehyde. Hx is oxidized to uric acid by the immobilized enzyme, the output current of the oxygen probe decreasing due to oxygen consumption. A linear relationship was obtained between current decrease and Hx concentration in the range 0.06–1.5 mM. The enzyme sensor could be used for more than 100 assays without decrease of output current After 30‐day‐storage at 5°C, no remarkable decrease of output current was observed. The enzyme sensor system was applicable to the simple, rapid, and economical determination of Hx in several fish meats including sea bass, saurel, mackerel, yellowfish, and flounder.
Multi-Exposure Image Fusion Based on Patch using Global and Local Characteristics (2018)

In this paper, we propose an algorithm that improves the weight map part consisting of signal strength, signal structure, and mean intensity. The patch-based conventional weight map causes the brightness of the image to be shifted to one side, resulting in loss of image information, unexpected artifacts, and an overall unbalance in image brightness. In this study, we propose a novel algorithm by improving the weight map. First, the order-statistic filter using maximum values. Second, the unsharp masking filter using Laplacian. Third, the linear combination using gamma transformation. The proposed algorithm prevents the loss of image information by reducing the over-saturation of the image, accurate representation of dark and bright areas by increasing contrast, and preserve the detail such as the edge. Through subjective and objective experimental results, it is confirmed that the proposed algorithm shows better performance than the conventional algorithms.
<i>In vitro</i>double-integrating-sphere optical properties of tissues between 630 and 1064 nm (1997)

The optical properties (absorption and scattering coefficients and the scattering anisotropy factor) were measured in vitro for cartilage, liver, lung, muscle, myocardium, skin, and tumour (colon adenocarcinoma CC 531) at 630, 632.8, 790, 850 and 1064 nm. Rabbits, rats, piglets, goats, and dogs were used to obtain the tissues. A double-integrating-sphere setup with an intervening sample was used to determine the reflectance, and the diffuse and collimated transmittances of the sample. The inverse adding-doubling algorithm was used to determine the optical properties from the measurements. The overall results were comparable to those available in the literature, although only limited data are available at 790-850 nm. The results were reproducible for a specific sample at a specific wavelength. However, when comparing the results of different samples of the same tissue or different lasers with approximately the same wavelength (e.g. argon dye laser at 630 nm and HeNe laser at 632.8 nm) variations are large. We believe these variations in optical properties should be explained by biological variations of the tissues. In conclusion, we report on an extensive set of in vitro absorption and scattering properties of tissues measured with the same equipment and software, and by the same group. Although the accuracy of the method requires further improvement, it is highly likely that the other existing data in the literature have a similar level of accuracy.
Effect of Long-Term Administration of Berberine on Scopolamine-Induced Amnesia in Rats (1997)

—The effect of berberine (BER) on scopolamine (SCOP)-induced amnesia was investigated in a step-through passive avoidance task in rats. It was observed that BER at the doses of 0.1 and 0.5 g/kg after 7-day or 14-day administration significantly improved SCOP-induced amnesia. The anti-amnesic effect of BER after 14-day administration on the SCOP-induced amnesia was significantly augmented by physostigmine or neostigmine, and completely reversed by scopolamine N-methylbromide. These results suggest that the antiamnesic effect of BER after 14-day administration may be related to the increase in the peripheral and central cholinergic neuronal system activity.
Anxiety-like behavior in Rett syndrome: characteristics and assessment by anxiety scales (2015)

We conclude that anxiety-like behavior is a prominent component of RTT's behavioral phenotype, which affects predominantly children with less severe neurologic impairment and has functional consequences. Based on available data on standardized instruments, the ADAMS and in particular its Social Avoidance subscale has the best psychometric properties and functional correlates that make it suitable for clinical and research applications.
Reduced-Order Model Development Using Proper Orthogonal Decomposition and Volterra Theory (2004)

A new approach for generating reduced-order models of fluid systems was developed using proper orthogonal decomposition in combination with Volterra theory. The method involves identifying fluid basis functions with proper orthogonal decomposition and applying systems realization theory to generate a low-dimensional model for the scalar coefficients. The method was tested on a two-dimensional inviscid flow over a bump with forcing. Eight fluid basis functions were identified, and the eigensystem realization algorithm was used to identify an eight-state, reduced-order model. Time histories of both the reduced-order coefficients and the expanded flowfield data accurately tracked the full-order results in both amplitude and phase (average error less than 5%). The reduced-order model demonstrated four-orders-of-magnitude reduction in compute time relative to the full system, which represents a computational improvement on the same order as the reduction in degrees of freedom.
Amino Acid Derivatives of Ligustrazine-Oleanolic Acid as New Cytotoxic Agents (2014)

A series of novel ligustrazine-oleanolic acid (TOA) derivatives were designed, and synthesized by conjugating amino acids to the 3-hydroxy group of TOA by ester bonds. Their cytotoxicity was evaluated on four cancer cell lines (HepG2, HT-29, Hela and BGC-823) by standard MTT assays. The ClogP values were calculated by means of computer simulation, and logP values of both 3β-glycine ester olean-12-en-28-oic acid-3,5,6-trimethylpyrazin-2-methyl ester (6a) and TOA were determined using a shake flask-ultraviolet spectrophotometry method. It was found that 6a and the 3β-L-lysine ester-6g not only displayed good cytotoxicity (IC50<3.5 μM) but also possessed better hydrophilicity than TOA. Moreover, 6a (IC50=4.884 μM) had lower nephrotoxicity than both 6g (IC50=2.310 μM) and cisplatin (CDDP, IC50=3.691 μM) on MDCK cells. Combining Giemsa and DAPI staining, it was further verified that 6a could induce HepG2 apoptosis via nuclei fragmentation and had lower nephrotoxicity. In addition, the structure-activity relationships of these derivatives are briefly discussed.
A study on subscriber optical line‐switching networks (1991)

Abstract In subscriber optical line networks, it is necessary to take measures to accompany the reliability improvements to efforts concerning the increases in the speed of information communications and the diversity of the services. In this paper, in regards to the structure of the line switching of the loop networks, the optimized settling method of the switch and its structure are investigated. The efficient switching method, in case of a failure, also is shown. Finally, the results of the trial manufacturing of the switch with the required functions are discussed. As the network structure, the one with its feeder lines pulled into many loop lines in one central office is modelled. In such network structures, exclusive protection lines are accommodated, taking into account the circuit failure ratio and the efficiency of line usage, etc. The switching is possible at the branching points of the feeder and the distribution lines between the service and the protection lines. By attaching the switching possibility at the feeding and crossing points to the protection lines, failure of one loop network is shown to be relieved effectively. Finally, the four‐terminal switch possessing the required functions in regards to the present line‐switching networks is proposed and compared against the usual 1 × 2 and 2 × 2 switches. It is shown that it is possible to realize the line‐switching networks with considerably reduced number of switches. Then, from the trial manufacturing results, the possibility of realization of high‐speed and low‐loss switches is indicated.
Structure–Activity Study of<i>N</i>-((<i>trans</i>)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1<i>H</i>)-yl)ethyl)cyclohexyl)-1<i>H</i>-indole-2-carboxamide (SB269652), a Bitopic Ligand That Acts as a Negative Allosteric Modulator of the Dopamine D<sub>2</sub>Receptor (2015)

We recently demonstrated that SB269652 (1) engages one protomer of a dopamine D2 receptor (D2R) dimer in a bitopic mode to allosterically inhibit the binding of dopamine at the other protomer. Herein, we investigate structural determinants for allostery, focusing on modifications to three moieties within 1. We find that orthosteric "head" groups with small 7-substituents were important to maintain the limited negative cooperativity of analogues of 1, and replacement of the tetrahydroisoquinoline head group with other D2R "privileged structures" generated orthosteric antagonists. Additionally, replacement of the cyclohexylene linker with polymethylene chains conferred linker length dependency in allosteric pharmacology. We validated the importance of the indolic NH as a hydrogen bond donor moiety for maintaining allostery. Replacement of the indole ring with azaindole conferred a 30-fold increase in affinity while maintaining negative cooperativity. Combined, these results provide novel SAR insight for bitopic ligands that act as negative allosteric modulators of the D2R.
Polyoxometalate assisted photoreduction of graphene oxide and its nanocomposite formation (2010)

We have developed a green method to reduce graphene oxide via a UV-irradiated photoreduction process in which H(3)PW(12)O(40) was used as photocatalyst. Moreover, H(3)PW(12)O(40) can adsorb on the reduced graphene oxide as anionic stabilizer and lead to water dispersible graphene sheets.
Elementary Excitations of a Linearly Conjugated Diatomic Polymer (1982)

The low-lying particlelike excitations of a model linearly conjugated diatomic polymer, ${(A=B)}_{x}$, are found to be pairs of either spin-0 or spin-\textonehalf{} solitons with irrational charge values. The charge values and excitation energies are calculated as functions of the difference of the energy levels of the atomic $p$ orbitals of the two atomic constitutents of the unit cell. The phonon spectrum of the uniform polymer is also calculated.
Evaluation of different solvent systems for the extraction and fractionation of oleoresins from guajillo peppers. (1997)

Dried guajillo peppers were first extracted with four different solvents: ethanol, acetone, ethyl acetate and hexane with the aim of obtaining oleoresins which were further fractionated into red and paprika extracts. Results showed that as the polarity of the solvent increased the amount of pigments extracted also increased. Acetone had good affinity for pungent (capsaicin) compounds. Utilization of these solvents alone did not produce red and paprika oleoresins that meet commercial specifications. Fractionation of acetone extracted oleoresins with ethanol: water (90:10) yielded a precipitate and a solution. The precipitate and solution produced red and paprika extracts that meet pungency and color specifications. It was possible to obtain red and paprika oleoresins from mild guajillo peppers.
Use of Uteroglobin for the Engineering of Polyvalent, Polyspecific Fusion Proteins (2009)

We report a novel strategy to engineer and express stable and soluble human recombinant polyvalent/polyspecific fusion proteins. The procedure is based on the use of a central skeleton of uteroglobin, a small and very soluble covalently linked homodimeric protein that is very resistant to proteolytic enzymes and to pH variations. Using a human recombinant antibody (scFv) specific for the angiogenesis marker domain B of fibronectin, interleukin 2, and an scFv able to neutralize tumor necrosis factor-alpha, we expressed various biologically active uteroglobin fusion proteins. The results demonstrate the possibility to generate monospecific divalent and tetravalent antibodies, immunocytokines, and dual specificity tetravalent antibodies. Furthermore, compared with similar fusion proteins in which uteroglobin was not used, the use of uteroglobin improved properties of solubility and stability. Indeed, in the reported cases it was possible to vacuum dry and reconstitute the proteins without any aggregation or loss in protein and biological activity.
Fabrication of MIM-GaAs solar cells for high concentration PV (2003)

Monolithic integrated modules (MIM) have proven to be effective, large area photovoltaic devices. They were developed for converting high-intensity light in thermo-photovoltaics. Applying this technique to GaAs solar cells opens a new path for low-cost terrestrial photovoltaic energy conversion. Parabolic dishes with a compact receiver area can be used as the concentrating optic. These are well established in the solar-thermal community. First GaAs-MIMs of 1 cm/sup 2/ have been fabricated at the Fraunhofer ISE. The design of the module, the fabrication technology and first results are presented. The electroluminescent light produced under forward bias is used to analyse the modules and locate defects, like shunts. Several shunting defects were observed but they do not affect the performance of the MlM at high concentration levels.