gebhart/patrepeval huggingface dataset:
2′-N-Guanidino,4′-C-ethylene bridged thymidine (GENA-T) modified oligonucleotide exhibits triplex formation with excellent enzymatic stability (2015)

We present the synthesis and characterization of 2′-<italic>N</italic>-guanidino,4′-<italic>C</italic>-ethylene bridged thymidine (GENA-T) modified oligo-DNA that forms a stable triplex (Δ<italic>T</italic><sub>m</sub> +9.5 °C) with exceptional nuclease stability.
Ruthenium Polyhydrido Clusters Having a Bridging Alkylzinc Group, [(η<sup>5</sup>-C<sub>5</sub>Me<sub>5</sub>)Ru(μ-H)]<sub>3</sub>(μ<sub>3</sub>-ZnR)<i><sub>n</sub></i>(μ<sub>3</sub>-H)<sub>2-</sub><i><sub>n</sub></i> and [(η<sup>5</sup>-C<sub>5</sub>Me<sub>5</sub>)Ru]<sub>2</sub>(μ-ZnR)<i><sub>n</sub></i>(μ-H)<sub>4-</sub><i><sub>n</sub></i> (R = Me and Et; <i>n</i> = 1 and 2) (2007)

Novel triruthenium polyhydrido complexes having triply bridging alkylzinc ligands, {Cp'Ru(μ-H)}3(μ3-ZnR)(μ3-H) (3a: R = Me, 3b: R = Et) and {Cp'Ru(μ-H)}3(μ3-ZnEt)2 (4a: R = Me, 4b: R = Et), are obtained by the reaction of {Cp'Ru(μ-H)}3(μ3-H)2 (2) with a stoichiometric amount of the corresponding dialkylzinc ZnR2. X-ray diffraction studies of 3b and 4a display the structural identity of those that have a triply bridging alkylzinc ligand. The X-ray studies as well as 1H NMR spectroscopy reveal the existence of bonding interactions between the μ3-zinc and the Ru-bound hydrido ligands in 3 and 4. In the variable-temperature 1H NMR study of 3b, activation parameters, ΔS⧧ and ΔH⧧, for the coordination-site exchange process among the hydrido ligands were estimated at −1.5 ± 1.3 cal mol-1 K-1 and 15.0 ± 0.4 kcal mol-1, respectively. The reaction of a diruthenium tetrahydrido complex, (Cp'Ru)2(μ-H)4 (1), with an equimolar amount of dialkylzinc yields (Cp'Ru)2(μ-ZnR)(μ-H)3 (5a: R = Me, 5b: R = Et). Di-μ-alkylzinc complexes, (Cp'Ru)2(μ-ZnR)2(μ-H)2 (6a: R = Me, 6b: R = Et), are formed in the reaction of 1 with twice the molar amount of dialkylzinc. The crossover reaction between 5b and 1 equiv of dimethylzinc proved the cis-geometry of the bridging alkylzinc ligands in 6. The variable-temperature 1H NMR experiment of 5 demonstrated fluxionality of the hydrido ligands, and the activation parameters were estimated at ΔS⧧ = −5.8 ± 2.0 cal mol-1 K-1 and ΔH⧧ = 11.0 ± 0.5 kcal mol-1 for 5a and ΔS⧧ = −12.4 ± 1.8 cal mol-1 K-1 and ΔH⧧ = 9.6 ± 0.5 kcal mol-1 for 5b by the line-shape analysis.
Effects of Nonsense Mutations on Nuclear and Cytoplasmic Adenine Phosphoribosyltransferase RNA (1996)

We have analyzed Chinese hamster ovary (CHO) cell mutants bearing nonsense codons in four of the five exons of the adenine phosphoribosyltransferase (aprt) gene and have found a pattern of mRNA reduction similar to that seen in systems studied previously: a decrease in steady-state mRNA levels of 5- to 10-fold for mutations in exons 1, 2, and 4 but little effect for mutations in the 3'-most exon (exon 5). Nuclear aprt mRNA levels showed a similar decrease. Nonsense-containing aprt mRNA decayed at the same rate as wild-type mRNA in these cell lines after inhibition of transcription with actinomycin D. Nonsense-containing aprt mRNA is associated with polysomes, ruling out a model in which stable residual mRNA escapes degradation by avoiding translation initiation. A tetracycline-responsive form of the aprt gene was used to compare the stability of nonsense-containing and wild-type aprt mRNAs without globally inhibiting transcription. In contrast to measurements made in the presence of actinomycin D, after inhibition of aprt transcription with tetracycline, a nonsense-mediated destabilization of aprt mRNA was indeed demonstrable. The increased rate of decay of cytoplasmic aprt mRNA seen here could account for the nonsense-mediated reduction in steady-state levels of aprt mRNA. However, the low levels of nonsense-bearing aprt mRNA in the nucleus suggest a sensibility of mRNA to translation or translatability before it exits that compartment. Quantitation of the steady-state levels of transcripts containing introns revealed no accumulation of partially spliced aprt RNA and hence no indication of nonsense-mediated aberrancies in splicing. Our results are consistent with a model in which translation facilitates the export of mRNA through a nuclear pore. However, the mechanism of this intriguing nucleocytoplasmic communication remains to be determined.
Split Custody as a Viable Post-Divorce Option (2000)

Abstract Split custody is an unpopular post-divorce family arrangement because of predictions that it deprives children of sibling support and impedes their adjustment to parents' divorce. The present study collected demographic details of two hundred split-custody families. Fifty-four parents and thirty children completed questionnaires. Thirty-nine of these parents and nineteen children were interviewed. Children's wishes contributed to the adoption of the arrangement in most families. Parents' unhappiness with split custody stemmed from their separation from a child. Children exercised frequent access to noncustodial parents and separated siblings. Split custody did not weaken sibling or parent/child relationships nor lead to parent/child alliances. It appeared to work well in many families for both parents and children.
A (1.fwdarw.4)-"trehazoloid" glucosidase inhibitor with aglycon selectivity (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA (1.fwdarw.4)-"trehazoloid" glucosidase inhibitor with aglycon selectivitySpencer Knapp, Ashok Purandare, Karen Rupitz, and Stephen G. WithersCite this: J. Am. Chem. Soc. 1994, 116, 16, 7461–7462Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ja00095a081https://doi.org/10.1021/ja00095a081research-articleACS PublicationsRequest reuse permissionsArticle Views370Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Efficient Approach to Time-Dependent Density-Functional Perturbation Theory for Optical Spectroscopy (2006)

Using a superoperator formulation of linearized time-dependent density-functional theory, the dynamical polarizability of a system of interacting electrons is represented by a matrix continued fraction whose coefficients can be obtained from the nonsymmetric block-Lanczos method. The resulting algorithm, which is particularly convenient when large basis sets are used, allows for the calculation of the full spectrum of a system with a computational workload only a few times larger than needed for static polarizabilities within time-independent density-functional perturbation theory. The method is demonstrated with calculation of the spectrum of benzene, and prospects for its application to the large-scale calculation of optical spectra are discussed.
Selective deposition of polycrystalline silicon thin films at low temperature by hot-wire chemical vapor deposition (1996)

Polycrystalline silicon thin films have been selectively deposited at a substrate temperature of 300 °C on molybdenum or silicon over silicon dioxide, silicon nitride or Corning 7059 glass substrates in a continuous hot-wire chemical vapor deposition (HWCVD) process involving hydrogen and disilane. Excellent selectivity is achieved on features as small as 1 μm spaced molybdenum lines. The deposition rate on molybdenum is 60–100 Å/min which is higher than that obtained by a pulsed gas plasma-enhanced chemical vapor deposition (PECVD) or a very high-frequency PECVD (VHF-PECVD). The selective deposition rate obtained in our system is attributed to the high concentration of atomic hydrogen generated when molecular hydrogen passes over a heated tungsten filament.
Ruthenium-based catalysts for the ring opening metathesis polymerisation of low-strain cyclic olefins and of functionalised derivatives of norbornene and cyclooctene (1995)

New, readily available catalyst systems based on [(arene)RuCl2phosphine] complexes activated by addition of trimethylsilyldiazomethane are very active for promoting the ring opening metathesis polymerisation (ROMP) of functionalised norbornenes and cyclooctenes.
Clinical characteristics and pathology of thyroid-like follicular carcinoma of the kidney: Report of 3 cases and a literature review (2015)

Thyroid-like follicular carcinoma (TLFC) of the kidney is an extremely rare type of renal tumor, which has not been classified under a known subtype of renal cell carcinoma. It is histologically similar to the primary thyroid follicular carcinoma; however, the characteristics lack thyroid immunohistochemical markers. The aim of the present study was to illustrate the clinical characteristics of 3 new cases along with a review of the literature. The patients were compared with regards to gender, age, location and size of the tumor, imageology, morphology, immunohistochemistry and prognosis. According to the limited data, TLFC occurs mainly in young women and its clinical manifestations have no difference with other renal tumors. Its imageological features resemble a large spectrum of benign and malignant renal and extra-renal conditions, which should be eliminated in the diagnostic process. Confirmed diagnosis depends on the examination of pathology and immunohistochemistry. Surgical ablation is the preferred therapeutic method. Currently, TLFC has a relatively good prognosis; however, this conclusion requires further cases and long-term follow-ups. Improving the understanding of TLFC can help avoid misdiagnosis and prevent inappropriate treatment.
<b>The Electronic Structures of Metal Nitrosyls and Carbonyls</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Electronic Structures of Metal Nitrosyls and CarbonylsHarry B. Gray, Ivan. Bernal, and Ernst. BilligCite this: J. Am. Chem. Soc. 1962, 84, 17, 3404–3405Publication Date (Print):September 1, 1962Publication History Published online1 May 2002Published inissue 1 September 1962https://pubs.acs.org/doi/10.1021/ja00876a037https://doi.org/10.1021/ja00876a037research-articleACS PublicationsRequest reuse permissionsArticle Views593Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High Performance Amorphous Polymeric Thin-Film Transistors Based on Poly[(1,2-bis-(2′-thienyl)vinyl-5′,5′′-diyl)-<i>alt</i>-(9,9-dioctylfluorene-2,7-diyl] Semiconductors (2008)

We have synthesized a new p-type polymer, poly[(1,2-bis-(2′-thienyl)vinyl-5′,5′′-diyl)-alt-(9,9-dioctyldecylfluorene-2,7-diyl] (PTVTF), via a Suzuki coupling reaction. PTVTF was found with UV–vis absorption spectroscopy, GIXD, AFM, and NEXAFS to be an ‘annealing-freeʼ amorphous polymer. Despite its amorphous nature, our time-of-flight measurements demonstrate that PTVTF is a good hole transport material with an intrinsic hole mobility of 2 × 10−4 cm2/Vs, which is comparable to those of crystalline polymers such as P3HT. A solution-processed PTVTF FET with a bottom gate/top contact geometry was found to exhibit good device performance with superior reproducibility. The field-effect mobility of holes was found to be 2 × 10−2 cm2/Vs with a good subthreshold swing of 1.7 Vdecade−1. The output characteristics indicate that good saturation and ohmic contact are present. The amorphous nature of PTVTF makes it a very promising candidate for commercial OTFTs since its properties are independent of fabrication conditions. From the temperature dependence of the mobility of amorphous PTVTF, we found that increases in the hydrophobicity of the dielectric substrate improve the mobility of PTVTF by reducing the trap density of the semiconductor layer.
Design of Adaptive PI Rate Controller for Best-Effort Traffic in the Internet Based on Phase Margin (2007)

In this paper, we propose an adaptive PI (proportional-integral) rate controller for the AQM (active queue management) router that would support best-effort traffic in the Internet. Unlike most window-based controllers, our rate-based controller design is derived from the classical control theory and it would allow the users to achieve good stability robustness of the AQM control system by specifying a proper phase margin. We also make our controller adaptive by selecting a simple heuristic parameter to monitor the network environment real-time so that the controller would self-tune only when a dramatic change of the network traffic has drifted the monitoring parameter outside its specified interval. Located in the router, the adaptive PI rate controller calculates desirable source window sizes (i.e., source sending rates) based on the instantaneous queue length of the buffer and advertises it to the sources. Our simulations demonstrate that our AQM control system can adapt very well to sudden changes in network environment, thus providing the network with good transient behavior. By making the source sending rate relatively smooth, our adaptive PI rate controller becomes quite suitable for streaming media traffic control in the Internet
Multi-class applications for parallel usage of a guaranteed rate and a scavenger service (2003)

Grid computing requires network services beyond what is currently provided by the Best-Effort Internet. Among the different approaches towards network Quality of Service, aggregate scheduling, which maps micro-flows to a small number of different service classes, offers sufficient scalability up to the size of the Internet. The Differentiated Services architecture of the Internet Engineering Task Force is such an approach. Recently further Best-Effort like services have been proposed that are based on aggregate scheduling, like the less than Best-Effort Scavenger Service and the Alternative Best-Effort Service. In this paper we introduce the existing aggregate based approaches to Quality of Service. We take a heterogeneous mix of Transmission Control Protocol and User Datagram Protocol flows into account and complement services by adding transport protocol specific elements, if appropriate. In particular we show multi-class applications that are designed to apply a Guaranteed Rate Service and a Scavenger Service in parallel. Doing so we can show a performance gain and achieve a more economical use of the available resources without impacting responsive Best-Effort flows.
Iterative Waterfilling for Weighted Rate Sum Maximization in MIMO-OFDM Broadcast Channels (2007)

We study the maximization of the weighted sum rate in Gaussian multi-input multi-output OFDM broadcast channel under a total power constraint. This problem is motivated by adaptive resource allocation policies in a multi-carrier wireless system with multiple antennas at the base station. We propose a iterative waterfilling algorithm based on dual decomposition. Two decompositions are considered, one in subcarrier domain and another in both subcarrier and user domain. We show that both decompositions reduce to an identical problem that can be solved by multiuser waterfilling approach simultaneously for all subcarriers. A master problem is solved iteratively to achieve the total power constraint by a simple bisection method. Numerical examples show that our proposed algorithm converges much faster than steepest ascent algorithm and makes convergence almost independent of a number of subcarriers and antennas.
Fire Detection System Performance in USAF Aircraft (1972)

The report is concerned with the determination of the performance of fire detection systems in USAF aircraft. Data on false fire warnings and aircraft engine nacelle fires were taken from Air Force accident/incident reports. These data included the time period 1965 through 1970 and is restricted to noncombat related accidents/incidents. Analysis of the data showed that false fire warnings are a major problem in the majority of USAF aircraft (83% of all reported alarms are false). These false fire warnings resulted in damage or destruction of aircraft as well as crew injuries/fatalities. In addition, it was found that in approximately 50% of the engine nacelle fires, where the performance of the detection system could be determined, the system did not provide an alarm. It was also found that the fire detection system in a number of aircraft had been partially or totally removed to reduce or eliminate the false fire warning problem. As a consequence the majority of the fires which occurred in these aircraft were not detected.
Use of the Finite-Difference Time-Domain Method in Calculating EM Absorption in Human Tissues (1987)

Although there are acceptable methods for calculating whole body electromagnetic absorption, no completely acceptable method for calculating the local specific absorption rate (SAR) at points within the body has been developed. Frequency domain methods, such as the method of moments (MoM) have achieved some success; however, MoM requires computer storage on the order of (3N) 2 and computation time on the order of (3N) 3 where N is the number of cells. The finite-difference time-domain (FDTD) method has been employed extensively in calculating the scattering of metallic objects, and recently is seeing some use in calculating the interaction of EM fields with complex, lossy dielectric bodies. Since the FDTD method has storage and time requirements proportional to N, it presents an attractive alternative to calculating SAR distribution in large bodies. This paper describes the FDTD method and evaluates it by comparing its results to analytic solutions in two and three dimensions. The utility of the FDTD method is demonstrated by a 3D scan of the human torso. The results obtained demonstrate that the FDTD method is capable of calculating internal SAR distribution with acceptable accuracy. With the availability of supercomputers, such as the CRAY II, the calculation of SAR distribution in a man model of 50 000 cells (1.27 cm per cell) appears to be feasible.
ChemInform Abstract: Photochromic Dihetarylethenes. Part 8. A Novel Route to the Synthesis of 3,4‐Bis(2,5‐dimethyl‐3‐thienyl)furan‐2,5‐dione as a Potential Photochrome. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A two‐dimensional morphological study of corneocytes from healthy dogs and cats and from dogs with atopic dermatitis (2009)

The aim of this study was to determine the dimensions of corneocytes collected from healthy dogs and cats, and from dogs suffering from atopic dermatitis. Samples were collected from the inner pinna, lateral thorax and the groin. D-Squame adhesive discs were used to collect corneocytes from the skin surface and image analysis software was used for measurements. Two differently shaped cells were identified in both animal species. The most common cell type was polygonal, often hexagonal or pentagonal and regular while the second type was smaller, elongated and variable in size and shape. The polygonal cells are corneocytes which probably originate from the interfollicular epidermis. The mean diameter and surface area for healthy canine polygonal corneocytes were 38-43.5 microm and 1092-1436 microm(2). The equivalent Figures for cats were 39.6-48.5 microm and 1183-1772 microm(2). Feline polygonal corneocytes were generally larger than those of the dog. Both feline and canine polygonal corneocytes collected from the ear were generally smaller than those from other body sites. Atopic canine polygonal corneocytes collected from the groin were significantly smaller than healthy groin corneocytes. In healthy dogs the mean length, breadth and surface area of elongated cells were 26.6-35.9 microm, 7.6-10.3 microm and 168.6-240.2 microm(2). The equivalent values for cats were 20.0-37.8 microm, 6.8-9.9 microm and 117.6-245.6 microm(2). The exact nature of the elongated cells is not known but they may be cell fragments or folded corneocytes. They were more common in densely haired skin suggesting the hair follicle as their origin.
A Tcl-based self-configuring embedded system debugger (1997)

The Tcl Environment for Extensible Modeling is a software system from Bell Labs for the simulation, hardware emulation and debugging of heterogeneous multiprocessor embedded systems. These embedded systems contain one or more digital signal processors or microcontrollers that execute real-time software written in assembly language and C. Tcl provides an environment in which embedded system designers can interact easily with their designs. Tcl serves as a processor query language, a modeling language for connecting and scheduling processors, an extension language for adding both model and environment enhancements, and as a user interface implementation language. Tcl's C API and calling conventions provide C and C++-level standards and portable libraries. The Tcl interpreter extends readily into a self-configuring simulation-emulation-debugging tool set. This tool set can use new processor types and new processor arithmetic without tool recompilation. This paper looks at exploitation of Tcl from a system perspective, and at some technical problems and solutions in applying Tcl.