gebhart/patrepeval huggingface dataset:
Self-Assembled Supramolecular Ferrocene−Fullerene Dyads and Triad:  Formation and Photoinduced Electron Transfer (2008)

Supramolecular ferrocene−fullerene constructs in which the donor, ferrocene linked to a benzo-18-crown-6 entity (Fc-crown), was self-assembled with the acceptor, fullerene bearing one or two alkyl ammonium ions (NH3+−C60), yielding dyads or a triad, respectively. The newly formed conjugates were characterized by spectroscopic (fluorescence, electospray ionization-mass, and 1H NMR) and electrochemical methods. The adopted crown ether−alkyl ammonium ion binding strategy resulting in stable donor−acceptor conjugates was also supported by the computational studies performed at the DFT B3LYP/3-21G(*) level in addition to the binding constants obtained from fluorescence quenching studies. The experimentally calculated free-energy changes indicated exothermic light-induced charge-separation process. Accordingly, efficient photoinduced charge-separation processes were confirmed by the combination of the time-resolved fluorescence and nanosecond transient absorption spectral measurements. The rates of charge recombination were found to be 2−3 orders of magnitude lower, yielding radical ion-pairs, Fc+-crown/NH3+-C60•- with lifetimes in the 10−240 ns range. Generally, by increasing the donor−acceptor distance, a decrease in both kCS and kCR was observed for the supramolecular ferrocene−fullerene dyads; that is, the lifetimes of Fc+-crown/NH3+-C60•- changed from 10 to 165 ns. However, for the triad, involving two ferrocene donors of varying donor−acceptor distances, the kCR originating from the far-side located ferrocene was found to be 240 ns while the kCR from the near-side located ferrocene was faster than the time duration of the nanosecond laser pulse (6 ns).
Anisotropy correction for deviated-well sonic logs: Application to seismic well tie (2002)

Abstract Borehole sonic logs acquired in deviated wells penetrating the HRZ and Colville shales in the Niakuk field in Alaska's North Slope are seen to be significantly faster than vertical well logs. These differences are attributed to shale anisotropy. An iterative inversion scheme was created to invert for shale anisotropy parameters using multiple wells penetrating shale sections at different angles. The inversion involves fitting the sonic log data at a range of borehole angles to the compressional wave group velocity surface. The result is an estimate of the anisotropy parameters (ε and δ) and the vertical P-wave velocity. The results show that the shales are strongly anisotropic, with compressional-wave anisotropy (Thomsen's parameter ε) on the order of 40% and the anisotropy parameter δ (relates vertical velocity to short-offset NMO velocity) around 10%. This large anisotropy can affect seismic imaging, AVO, and time–depth calculations. A procedure was created to estimate the anisotropy-corrected vertical sonic logs from sonic data recorded in a deviated well. The inputs are well deviation, P-wave sonic log, volume of shale or gamma ray data, and anisotropy parameters for rock with 100% shale volume. With these inputs the compressional-wave group velocity surface is computed and the equivalent vertical P-wave sonic log is output. The equivalent vertical sonic log can then be used for standard seismic applications using isotropic velocity assumptions. The application was applied to a well deviated at approximately 67°. Shale anisotropy parameters were taken from the sonic log inversion, and an anisotropy-corrected sonic log was produced. Seismic well ties were attempted using both the recorded logs and the anisotropy-corrected logs, with the result that the well tie using the measured logs was poor while a tie using the anisotropy-corrected logs was good.
In situ localization by double-labeling immunoelectron microscopy of anti-neutrophil cytoplasmic autoantibodies in neutrophils and monocytes (1990)

Anti-neutrophil cytoplasmic autoantibodies (ANCA) associated with active Wegener's granulomatosis are directed against a soluble 29-Kd protein present in human neutrophils and monocytes. Affinity labeling with tritiated diisopropylfluorophosphate (3H-DFP) suggested that ANCA-antigen is a serine protease. We used immunoelectron microscopy to study the in situ localization of the ANCA-antigen in normal human neutrophils and monocytes using immunoglobulin G (IgG) from ANCA-positive patients and a mouse monoclonal antibody against the ANCA-antigen. Label was observed on the large granules of the neutrophils and in granules of monocytes. Double-labeling, using anti-myeloperoxidase or the peroxidase reaction as markers for azurophil granules and anti-lactoferrin as marker for specific granules, showed that ANCA is colocalized with markers of azurophil granules but not with lactoferrin. Furthermore, elastase and cathepsin G were found in the azurophil granules of neutrophils and in the peroxidase-positive granules of monocytes, colocalized with ANCA-antigen. Cytochalasin-B-treated neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP) formed large intracellular vacuoles and were partially degranulated. Some vacuoles contained ANCA-antigen, as well as myeloperoxidase, elastase, and cathepsin G, demonstrating release of these enzymes from the azurophil granules into vacuoles. Our results demonstrate that ANCA-antigen is located in myeloperoxidase-containing granules of neutrophils and monocytes, and is packaged in the same granules as elastase and cathepsin G, the two previously identified serine proteases of myeloid leukocytes.
Characterization of Hybrid Atmospheric Plasma in Air and Nitrogen (2006)

This thesis presents experimental and modelling research on atmospheric pressure hollow cathodes and hollow electrodes. Experiments with the hybrid hollow electrode activated discharge (H-HEAD), which is a combination of a hollow cathode and a microwave plasma source, is presented. The experiments show that this source is able to produce long plasma columns in air and nitrogen at atmospheric pressure and at very low gas flow rates. Measurements of the vibrational temperature of the nitrogen molecules are also presented in this thesis. The vibrational temperature is an indication of the electron temperature in the plasma, an important characteristic of the plasma. Modelling work on the hollow cathode at atmospheric pressure with fluid equations is also presented. It is shown that the inclusion of fast and secondary electrons, characteristic of the hollow cathode plasmas, increases the sheath width. The sheath width was found to be of the order of 100 μm. By modelling the plasma as highly collisional by using the drift-diffusion approximation, it was shown that the increase in sheath thickness was larger at lower pressures than at higher pressures. Still, the sheath width can be of the order of 100 μm. A pulsed atmospheric plasma in a hollow electrode geometry was also modelled by the drift-diffusion fluid equations, with the addition of the energy equation for electrons. Rate and transport coefficients for the electrons were calculated from the solution to the Boltzmann equation as functions of mean electron energy. The dynamics of the plasma at pulse rise time showed large electron density and mean energy peaks at the cathode ends, but also that these quantities were enhanced at the centre of the discharge, between the cathode plates.
An SVM learning approach to robotic grasping (2004)

Finding appropriate stable grasps for a hand (either robotic or human) on an arbitrary object has proved to be a challenging and difficult problem. The space of grasping parameters coupled with the degrees-of-freedom and geometry of the object to be grasped creates a high-dimensional, non-smooth manifold. Traditional search methods applied to this manifold are typically not powerful enough to find appropriate stable grasping solutions, let alone optimal grasps. We address this issue in this paper, which attempts to find optimal grasps of objects using a grasping simulator. Our unique approach to the problem involves a combination of numerical methods to recover parts of the grasp quality surface with any robotic hand, and contemporary machine learning methods to interpolate that surface, in order to find the optimal grasp.
Isolated sub-fs XUV pulse generation in Mn plasma ablation (2012)

We report studies of high-order harmonic generation in laser-produced manganese plasmas using sub-4-fs drive laser pulses. The measured spectra exhibit resonant enhancement of a small spectral region of about 2.5 eV width around the 31st harmonic (~50eV). The intensity contrast relative to the directly adjacent harmonics exceeds one order of magnitude. This finding is in sharp contrast to the results reported previously for multi-cycle laser pulses [Physical Review A 76, 023831 (2007)]. Theoretical modelling suggests that the enhanced harmonic emission forms an isolated sub-femtosecond pulse.
Endoscopic Release in Carpal Tunnel Syndrome: Analysis of Clinical Results in 200 Cases (2003)

Carpal tunnel syndrome is the most common peripheral neuropathy. Conventional carpal tunnel surgery has been performed as a primary procedure for the decompression of the median nerve at the wrist in patients who have idiopathic carpal tunnel syndrome. While the results have been excellent, this surgical procedure has been reported to be related to high postoperative morbidity and extended length of recovery time. Over the past decade, endoscopic release of the transverse carpal ligament has been developed as a new, alternative method to the open procedures. Endoscopic carpal tunnel release has been reported to ensure less postoperative morbidity, more rapid recovery of strength, with earlier return to work, reduced disability time and a better cosmetic result. The authors present a surgical series of 200 hands in 164 patients (36 bilaterals) with idiopathic carpal tunnel syndrome, who underwent a single-portal endoscopic carpal tunnel release (Agee technique), with regards to the clinical outcome and complications occurred after 4-months follow-up.
Event Indexing and Searching for High Volumes of Event Streams in the Cloud (2012)

Deployed software applications use log files to keep a record of system events. Log analysis provides support for system administrators to gain the knowledge of system health and behavior. As a result, the ability to efficiently search for patterns in historical events has become a major requirement for timely analysis. Enterprise systems today produce high volumes of log data, regularly in the order of thousands of events per second, which requires to build inverted indexes for quick data retrieval. However, current inverted indexing techniques are rarely designed to handle high volumes of dynamic stream data and often resource consuming. We propose an efficient indexing solution, which reduces the necessary resources by employing bloom filter techniques. The solution builds a generic indexing engine for the Run Time Correlation Engine logging framework to achieve efficient monitoring in the Cloud. In particular, our solution is able to deliver significant performance improvement over existing indexing engines.
1 Einleitung (2016)

Informationen spielen die entscheidende Rolle für Entscheidungen in Unternehmen. Zugleich sind mit der Informationsbeschaffung, -verarbeitung und -weitergabe erhebliche Kosten verbunden. Informationsmanagement betrifft demnach sowohl die technische Seite der Wirtschaftsinformatik als auch die ökonomische Sichtweise des Controlling einschließlich der internen Rechnungslegung.
A Novel Neural Network for the Synthesis of Antennas and Microwave Devices (2005)

A novel artificial neural network (SYNTHESIS-ANN) is presented, which has been designed for computationally intensive problems and applied to the optimization of antennas and microwave devices. The antenna example presented is optimized with respect to voltage standing-wave ratio, bandwidth, and frequency of operation. A simple microstrip transmission line problem is used to further describe the ANN effectiveness, in which microstrip line width is optimized with respect to line impedance. The ANNs exploit a unique number representation of input and output data in conjunction with a more standard neural network architecture. An ANN consisting of a heteroassociative memory provided a very efficient method of computing necessary geometrical values for the antenna when used in conjunction with a new randomization process. The number representation used provides significant insight into this new method of fault-tolerant computing. Further work is needed to evaluate the potential of this new paradigm.
Mechanisms of Immune Evasion Induced by a Complex of Dengue Virus and Preexisting Enhancing Antibodies (2010)

We have found that dengue virus (DENV) not only uses preexisting enhancing antibodies to promote its entry into Fc receptor-bearing cells but also exploits enhancing antibodies for intracellular immune evasion through 2 mechanisms. In the first mechanism, entry of DENV-antibody complexes into human monocytic cells activates negative regulators, dihydroxyacetone kinase and autophagy-related 5-autophagy-related 12, which then disrupt the retinoic acide incucible gene I and melanoma differentiation associated gene 5 signaling cascade and disable type 1 interferon production, leading to suppression of interferon-mediated antiviral responses. In the second mechanism, the immune evasion was found to be mediated by the suppressive cytokine interleukin 10 (IL-10). High levels of IL-10 activated expression of suppressor of cytokine signaling 3 gene, which subsequently inactivated the Janus kinase-signal transducer and activator of transcription pathway. Inhibition of IL-10 production by small interfering RNA down-regulated suppressor of cytokine signaling 3 gene expression, restored inducible nitric oxide synthase gene expression, and suppressed DENV replication. Importantly, we were able to demonstrate that these 2 loops of suppression occurred in patients with severe secondary dengue infection (dengue hemorrhagic fever) but not in patients with mild secondary dengue infection (dengue fever).
Volumetric ultrasound image-forming using fully controllable 2-D CMUT-on-ASIC arrays (2013)

In real-time 3-D ultrasound imaging using 2-D array transducers, a large number of the 2-D array elements pose challenges in fabricating and transferring signals from/into the system. This fabrication problem has been solved by using a silicon micromachining process for capacitive micromachined ultrasonic transducer (CMUT) arrays. For realtime 3-D ultrasound imaging, manipulating massive ultrasound data acquired from a large number of system channels is a challenge as is fabricating and interconnecting hundreds or thousands of elements of 2-D array with the imaging system’s front-end (FE) electronics. Minimizing the number of transmitting and receiving elements and the firing events without degrading the image quality is one of the solutions to reduce the overall system complexity and improve the frame rate. We have been developing a real-time 3-D volumetric ultrasound imaging system using 2-D CMUT arrays by integrating FE electronics with a large number of 2-D array elements. Here, we explore a configuration method to design a scalable 2-D CMUT array and a new volumetric image-formation method to provide higher information rate of a volume image. In this paper, we present the 2-D CMUT-on-ASIC arrays designed to reduce the overall system complexity, and a new volume scanning and image-forming method for real-time 3-D volumetric ultrasonic imaging using 2-D CMUT-on-ASIC arrays. To evaluate our works, we performed from theoretical studies for point spread functions of the array configuration to phantom experiments with off-the-line images.
Modeling optical behavior of birefringent biological tissues for evaluation of quantitative polarized light microscopy (2009)

Quantitative polarized light microscopy (qPLM) is a popular tool for the investigation of birefringent architectures in biological tissues. Collagen, the most abundant protein in mammals, is such a birefringent material. Interpretation of results of qPLM in terms of collagen network architecture and anisotropy is challenging, because different collagen networks may yield equal qPLM results. We created a model and used the linear optical behavior of collagen to construct a Jones or Mueller matrix for a histological cartilage section in an optical qPLM train. Histological sections of tendon were used to validate the basic assumption of the model. Results show that information on collagen densities is needed for the interpretation of qPLM results in terms of collagen anisotropy. A parameter that is independent of the optical system and that measures collagen fiber anisotropy is introduced, and its physical interpretation is discussed. With our results, we can quantify which part of different qPLM results is due to differences in collagen densities and which part is due to changes in the collagen network. Because collagen fiber orientation and anisotropy are important for tissue function, these results can improve the biological and medical relevance of qPLM results.
Inhibition of Heme Oxygenase-1 Interferes with the Transforming Activity of the Kaposi Sarcoma Herpesvirusencoded G Protein-coupled Receptor (2006)

Heme oxygenase-1 (HO-1), the inducible enzyme responsible for the rate-limiting step in the heme catabolism, is expressed in AIDS-Kaposi sarcoma (KS) lesions. Its expression is up-regulated by the Kaposi sarcoma-associated herpesvirus (KSHV) in endothelial cells, but the mechanisms underlying KSHV-induced HO-1 expression are still unknown. In this study we investigated whether the oncogenic G protein-coupled receptor (KSHV-GPCR or vGPCR), one of the key KSHV genes involved in KS development, activated HO-1 expression. Here we show that vGPCR induces HO-1 mRNA and protein levels in fibroblasts and endothelial cells. Moreover, targeted knock-down gene expression of HO-1 by small hairpin RNA and chemical inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPP), impaired vGPCR-induced survival, proliferation, transformation, and vascular endothelial growth factor (VEGF)-A expression. vGPCR-expressing cells implanted in the dorsal flank of nude mice developed tumors with elevated HO-1 expression and activity. Chronic administration of SnPP to the implanted mice, under conditions that effectively blocked HO-1 activity and VEGF-A expression in the transplanted cells, strikingly reduced tumor growth, without apparent side effects. On the contrary, administration of the HO-1 inducer cobalt protoporphyrin (CoPP) further enhanced vGPCR-induced tumor growth. These data postulate HO-1 as an important mediator of vGPCR-induced tumor growth and suggest that inhibition of intratumoral HO-1 activity by SnPP may be a potential therapeutic strategy.
A new theory for electroded piezoelectric plates and its finite element application for the forced vibrations analysis of quartz crystal resonators (2002)

For crystal resonators, it is always desirable to calculate the electric properties accurately for application purposes. As an extension of the Mindlin plate theory based finite element analysis of crystal resonators, a new theory for the electroded plates is derived and the piezoelectrically forced vibrations are formulated and implemented in this paper in a manner similar to our previous work. The effect of the electrodes and the electric boundary conditions are taken into considerations through the modification of the higher-order plate equations by changing the expansion function of the electric potential for this particular problem. Through the conventional discretization of the new plate theory, the linear equations for the piezoelectric plate under thickness excitation are constructed and solved with efficient numerical computation techniques such as the sparse matrix handling. Numerical examples showing good predictions of the resonance frequency and capacitance ratio of electroded crystal plates of AT-cut quartz are presented with experimental data.
Client‐side monitoring for Web mining (2003)

Abstract “Garbage in, garbage out” is a well‐known phrase in computer analysis, and one that comes to mind when mining Web data to draw conclusions about Web users. The challenge is that data analysts wish to infer patterns of client‐side behavior from server‐side data. However, because only a fraction of the user's actions ever reaches the Web server, analysts must rely on incomplete data. In this paper, we propose a client‐side monitoring system that is unobtrusive and supports flexible data collection. Moreover, the proposed framework encompasses client‐side applications beyond the Web browser. Expanding monitoring beyond the browser to incorporate standard office productivity tools enables analysts to derive a much richer and more accurate picture of user behavior on the Web.
Simultaneous vibration and humidity measurement using a hybrid WDM/OCDMA sensor network (2013)

In this paper a hybrid Wavelength Division Multiplexing (WDM) and Optical Code Division Multiple Access (OCDMA) sensor network is proposed to detect vibration and humidity simultaneously. Evaluation of the results for the proposed system is demonstrated using simulation setup. OCDMA is used for detection of vibration levels while WDM is for sensing humidity changes. Fiber Bragg gratings (FBGs) is used in both systems. In OCDMA FBGs were used as filter to form the OCDMA code and sensors to senses the vibration. In WDM FBGs were used as sensor alone to sense the humidity.
Detection of <i>Porphyromonas gingivalis</i> DNA in Aortic Tissue by PCR (2002)

These results might indicate a link between periodontopathogens entering the cardiovascular system and cardiovascular disease.
Latchup performance of retrograde and conventional n-well CMOS technologies (1987)

The static and transient latchup performance of conventional and retrograde n-well CMOS technologies is compared. The retrograde n-well structures are shown to have superior latchup immunity, due primarily to the reduced n-well sheet resistance and the greater tolerance to thin p on p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> epitaxial material.