gebhart/patrepeval huggingface dataset:
A PKI based timestamped secure signing tool for e-documents (2014)

With digitization of documents becoming a buzz word, several research initiatives have been taken in the field. However, an associated challenge that arises is the process of certifying and validating document integrity and ensuring non-repudiation. E-signatures gave a solution but could not prove the signer's identity. Digital certificates were thereafter used along with signatures to prove the identity of the signer. In this paper we present a schema for embedding digital signature as well as certifying and verifying the content of electronic document in a secured and tamperproof manner. Digital signature is created with hash value of the document generated by a hashing algorithm and encrypting the hash value by private key of the signer. Finally, the document is time stamped by an authorized time stamping server. The paper incorporates a novel online validation mechanism for ensuring the usage of live certificate in signing the document and also checks the integrity of the document. It also suppresses the replay attack by encrypting user credential at one end and decrypting and verifying it at the other end with asymmetric key cryptography. Another unique mechanism incorporated to redundantly suppress replay attach is to embed a timestamp, generated by authorized third party time-stamping authority, which registers and verifies user identity. The system was exposed to security vulnerability assessment using a suite of tools as well as other mechanisms reported in literature. Results of attack assessment indicated that the system is capable of handling most of the dangerous threats and vulnerabilities.
Construction of sports business professional competence cultivation indicators in Asian higher education (2013)

The focus of this research was on the professional competence indicators of Asian sports business professionals. The aim of the research was to establish how scholars planned classes and programmes at the sports business related departments at colleges in Taiwan, Japan, Korea and China by making use of a questionnaire. By analysing selected literature, the first draft of a questionnaire was generated. By combining inputs from the scholars and experts from each country,the questionnaire was finalised. This was followed by a survey involving senior professors from China, Japan, Korea and Taiwan. A total of 40 academics, 10 from each country, served as the research sample. The analysis revealed the following: General abilities, such as working attitude, communication, and creativity, were recognised by academia as the important abilities for sports business professionals; Professional skills and professional knowledge were valued as less important than the general abilities; There was no difference in sports business professional competence indicators among the main Asian countries.
Investigation of Dopamine Analogues: Synthesis, Mechanistic Understanding, and Structure–Property Relationship (2016)

Dopamine, perhaps the simplest molecule that covalently links catechol and amine, together with its derivatives, has shown impressive adhesive and coating properties with its polymers. However, the scope of the molecules is rather limited, and the polymerization mechanisms are still elusive. We designed a general synthetic scheme and successfully synthesized a series of dopamine analogues with different alkyl chain lengths between the catechol and amine. Taking these new dopamine analogues, together with the molecular systems that have separate catechol and alkyl amine, we show that having both catechol and amine in the molecular system, whether covalently linked via an alkyl chain or not, is sufficient to polymerize under a similar reaction condition to that of dopamine polymerization. However, the time-dependent UV-vis characterization of the individual polymerization indicates that the polymerization for individual molecular systems likely proceeds via different reaction intermediates, depending on the length of the alkyl chain and whether there is a covalent linkage. Interestingly, whereas the covalent linkage via an alkyl chain is not necessary for showing the adhesive property, it is required to achieve the impressive coating property. Our results offer new insights into the design and synthesis of dopamine analogues for future applications, as well as a further mechanistic understanding of the polymerization of these dopamine analogues.
Bis(methimazolyl)silyl Complexes of Ruthenium (2010)

The new bis(methimazolyl)silane PhSiH(mt)2 (mt = methimazolyl), obtained from methimazole (Hmt) and phenyldichlorosilane, reacts with [Ru(η4-C8H12)(η6-C8H10)] in refluxing tetrahydrofuran to provide the cis and trans isomers of [Ru{κ3Si,S,S′-SiPh(mt)2}]. The structurally characterized trans isomer crystallizes directly from THF but on dissolution in CH2Cl2 converts exclusively to the cis isomer.
Resource Slicing in Virtual Wireless Networks: A Survey (2016)

New architectural and design approaches for radio access networks have appeared with the introduction of network virtualization in the wireless domain. One of these approaches splits the wireless network infrastructure into isolated virtual slices under their own management, requirements, and characteristics. Despite the advances in wireless virtualization, there are still many open issues regarding the resource allocation and isolation of wireless slices. Because of the dynamics and shared nature of the wireless medium, guaranteeing that the traffic on one slice will not affect the traffic on the others has proven to be difficult. In this paper, we focus on the detailed definition of the problem, discussing its challenges. We also provide a review of existing works that deal with the problem, analyzing how new trends such as software defined networking and network function virtualization can assist in the slicing. We will finally describe some research challenges on this topic.
Role of uncertainty in sensorimotor control (2002)

Neural signals are corrupted by noise and this places limits on information processing. We review the processes involved in goal-directed movements and how neural noise and uncertainty determine aspects of our behaviour. First, noise in sensory signals limits perception. We show that, when localizing our hand, the central nervous system (CNS) integrates visual and proprioceptive information, each with different noise properties, in a way that minimizes the uncertainty in the overall estimate. Second, noise in motor commands leads to inaccurate movements. We review an optimal-control framework, known as 'task optimization in the presence of signal-dependent noise', which assumes that movements are planned so as to minimize the deleterious consequences of noise and thereby minimize inaccuracy. Third, during movement, sensory and motor signals have to be integrated to allow estimation of the body's state. Models are presented that show how these signals are optimally combined. Finally, we review how the CNS deals with noise at the neural and network levels. In all of these processes, the CNS carries out the tasks in such a way that the detrimental effects of noise are minimized. This shows that it is important to consider effects at the neural level in order to understand performance at the behavioural level.
Challenges when transferring technology from Lactococcus laboratory strains to industrial strains. (2003)

Many genetically modified Lactococcus strains have been constructed in research laboratories around the world. Most of these have originated from laboratory strains and therefore there are several barriers to using them in an industrial setting. Laboratory strains are often plasmid-free and consequently Lac- and Prt-, rendering them unable to grow in milk. Many of the commonly used techniques have been optimised for laboratory strains and their application to industrial strains may require a great deal of effort. Often genetically modified organisms produced in the laboratory do not fit the published definition of 'food-grade' (Johansen, 1999, Encyclopedia of Food Microbiology, Academic Press, London, pp. 917-921) and a great deal of effort is required to eliminate undesirable DNA sequences. As a consequence, it is often necessary to recreate the strains in industrial backgrounds before the innovations described in the scientific literature can be applied to the real-world dairy industry.
Influence of Soil Temperature on Rhizoctonia Root Rot (<i>R. solani</i>AG-8 and<i>R. oryzae</i>) of Winter Wheat (1993)

Rhizoctonia solani AG-8 and R. oryzae are associated with Rhizoctonia root rot of cereals in the northwestern United States. These pathogens were evaluated in the greenhouse and field for effects on disease severity and growth, development, and yield of winter wheat. Experiments in the greenhouse were performed either with pasteurized soil mixture or intact cores of natural soil collected from the field. Soil temperatures were controlled at diurnal cycles of 27/16, 23/11, or 19/6 C, or experiments were performed at ambient temperatures of 28/15 C. Inocula of the Rhizoctonia species were also placed in a band below winter wheat seed in the field. R. solani caused moderate to severe disease and reduced plant growth and development in all six greenhouse and field tests [...]
Long non-coding RNA <i>HNF1A-AS1</i> regulates proliferation and migration in oesophageal adenocarcinoma cells (2013)

We have discovered abnormal upregulation of a lncRNA, HNF1A-AS1, in human EAC. Our findings suggest that dysregulation of HNF1A-AS1 participates in oesophageal tumorigenesis, and that this participation may be mediated, at least in part, by modulation of chromatin and nucleosome assembly as well as by H19 induction.
Influence of Stearic Acid on Lubricating Greases Containing Zinc Dialkyl Dithiophosphate. (1995)

Zinc dialkyl dithiophosphate (ZDTP) is an excellent additive. However, ZDTP is a strong polar substance, and when used as an additive in lithium base or lithium-calcium base greases, it causes at least two adverse effects: the grease's water resistance declines sharply, and the grease causes severe copper corrosion. The authors report that putting stearic acid into either lubricating grease not only improves its water resistance and copper corrosion, but also upgrades its antiwear property, without causing any other adverse effects
Regulation of IMP dehydrogenase gene expression by its end products, guanine nucleotides. (1991)

To study the regulation of IMP dehydrogenase (IMPDH), the rate-limiting enzyme of guanine nucleotide biosynthesis, we examined the effects of nucleosides, nucleotides, nucleotide analogs, or the IMPDH inhibitor mycophenolic acid (MPA) on the steady-state levels of IMPDH mRNA. The results indicated that IMPDH gene expression is regulated inversely by the intracellular level of guanine ribonucleotides. We have shown that treatment with guanosine increased the level of cellular guanine ribonucleotides and subsequently reduced IMPDH steady-state mRNA levels in a time- and dose-dependent manner. Conversely, MPA treatment diminished the level of guanine ribonucleotides and increased IMPDH mRNA levels. Both of these effects on the steady-state level of IMPDH mRNA could be negated by cotreatment with guanosine and MPA. The down regulation of IMPDH gene expression by guanosine or its up regulation by MPA was not due to major changes in transcriptional initiation and elongation or mRNA stability in the cytoplasm but rather was due to alterations in the levels of the IMPDH mRNA in the nucleus. These results suggest that IMPDH gene expression is regulated by a posttranscriptional, nuclear event in response to fluctuations in the intracellular level of guanine ribonucleotides.
Shermilamine A: A pentacyclic alkaloid from a tunicate (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTShermilamine A: A pentacyclic alkaloid from a tunicateNiranjala M. Cooray, Paul J. Scheuer, Laszlo Parkanyi, and Jon ClardyCite this: J. Org. Chem. 1988, 53, 19, 4619–4620Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/jo00254a049https://doi.org/10.1021/jo00254a049research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Joint IDF-IUPAC-IAEA(FAO) interlaboratory validation for determining aflatoxin M<sub>1</sub> in milk by using immunoaffinity clean-up before thin-layer chromatography (2004)

A collaborative study was conducted under the auspices of the International Dairy Federation (IDF), the International Union of Pure and Applied Chemistry (IUPAC) and the International Atomic Energy Agency (IAEA), a collaborative Food and Agricultural Organization (FAO) body fully to validate a method combining immunoaffinity clean-up to thin-layer chromatography for the determination of aflatoxin M(1) in milk. Work was done in order to afford those laboratories not equipped with high-performance liquid chromatography, mainly from developing countries, with a simplified but fully validated method as an alternative to the European validated immunoaffinity-high performance liquid chromatography method published as an EN ISO Standard 14501, February 1999. The validation study was carried out on samples of aflatoxin M(1)-contaminated milk and milk powder at levels close to the tolerable level of 0.5 microg l(-1) as recommended by the Codex Alimentarius and to the regulatory level of 0.05 microg l(-1) as laid down by the European Commission. Fourteen laboratories representing 11 countries participated in the trial. The relative standard deviations for repeatability and reproducibility based on raw data were in the range 27-48 and 35-54%, respectively. The recovery rate varied from 32 to 120%. The mishandling of two crucial steps of the protocol such as matrix sample reconstitution and extract evaporation could explain the wide variation of the recovery rate. For this reason, data were then corrected for recovery. Consequently, the relative standard deviations for repeatability and reproducibility were recalculated after correction for recovery and were in the range 26-54 and 34-53%, respectively. The method will be published as a standard ISO/DIS 14674--IDF 190.
Smartphone-based real-time object recognition architecture for portable and constrained systems (2021)

Abstract Machine learning algorithms based on convolutional neural networks (CNNs) have recently been explored in a myriad of object detection applications. Nonetheless, many devices with limited computation resources and strict power consumption constraints are not suitable to run such algorithms designed for high-performance computers. Hence, a novel smartphone-based architecture intended for portable and constrained systems is designed and implemented to run CNN-based object recognition in real time and with high efficiency. The system is designed and optimised by leveraging the integration of the best of its kind from the state-of-the-art machine learning platforms including OpenCV, TensorFlow Lite, and Qualcomm Snapdragon informed by empirical testing and evaluation of each candidate framework in a comparable scenario with a high demanding neural network. The final system has been prototyped combining the strengths from these frameworks and led to a new machine learning-based object recognition execution environment embedded in a smartphone with advantageous performance compared with the previous frameworks.
Intraarticular hyaluronic acid injection and synovial prostaglandins in experimental immune synovitis. (1983)

In vitro studies suggest that synovial fluid hyaluronic acid may have a role in reducing joint inflammation. The effect of intraarticular injection of sodium hyaluronate in a model of experimental immune synovitis was assessed. In addition, tissue prostaglandin content of synovia with and without immune synovitis was compared. Intraarticular hyaluronic acid administered at 2 doses was not effective in reducing the induced inflammation. With immune synovitis there was an increase in the total synovial prostaglandins. When related to total prostaglandins, prostacyclin was decreased, prostaglandin F2 alpha and thromboxane were increased and prostaglandin E2 was the same in synovitis as compared to controls.
Mixed Metastatic Lung Cancer Lesions in Bone Are Inhibited by Noggin Overexpression and Rank:Fc Administration (2006)

The NSCLC cell line A549 forms a mixed osteolytic/osteoblastic lesion in vivo. Noggin overexpression inhibited the formation of the osteoblastic aspect of the lesion in bone and the tumor growth in vivo. Treatment with RANK:Fc limited the formation of the lytic aspect of the mixed lesion and also inhibited the rate of in vivo tumor growth. Inhibition of both pathways is necessary to effectively inhibit the progression of mixed metastatic lesions in bone.
Isolation and Culture of Colon Cancer Cells and Cell Lines (2011)

The preparation of cells from heavily contaminated tissue is challenging. It is usually best to avoid such specimens if possible, but for the study of colorectal and some other tumours, it is inevitable that this must be overcome. The best methods seem to use a combination of (1) debridement of necrotic or infected areas of the tumour, (2) enzymatic dissociation in the presence of antibiotics, (3) density centrifugation to remove debris, and (4) extensive washing of the tumour-derived cells prior to their use in cell culture methods. It is possible to obtain cells from up to 80-90% tumours with careful technique and cooperation from the clinical team.
Power Generation With Pressure Retarded Osmosis (2013)

Energy can be generated from two streams of different salt concentration using the osmotic pressure difference. Different methods have been proposed to harvest this energy. Pressure retarded osmosis (PRO) is investigated as a viable method and most promising technology. In PRO process, pure water permeates through a semi permeable membrane from the low hydrostatic pressure stream (feed solution) to the higher hydrostatic pressure stream (draw solution) due to the osmotic pressure difference. This increases the volume flow rate of the pressurized draw stream and energy is obtained by depressurizing the draw stream through a hydro turbine. In this study a one-dimensional computational model is developed to precisely estimate the power production under different operating conditions. Different feed and draw solution concentrations are used to estimate the power production from PRO. The maximum power density (power per unit membrane area), using available membrane characteristics, obtained from seawater–freshwater streams is 2.6 W/m2 and for the disposed brine–seawater streams is 9.1 W/m2. The performance of PRO process is very sensitive to the membrane characteristics in particular to the water permeability and PRO module configuration.
Neuroprotection by Recombinant Thrombomodulin (2000)

We examined whether recombinant human soluble thrombomodulin (rhs-TM) reduces compression trauma-induced spinal cord injury through protein C activation in rats. Administration of rhs-TM, either before or after the induction of spinal cord injury (SCI), markedly reduced the resulting motor disturbances. However, neither rhs-TM pretreated with an anti-rhs-TM monoclonal antibody (MAb) F2H5, which inhibits thrombin binding to rhs-TM, nor those pretreated with MAb R5G12, which selectively inhibits protein C activation by rhs-TM, prevented the motor disturbances. Intramedullary hemorrhages, observed 24 h after trauma, were significantly reduced in animals given rhs-TM. The increase in the tissue levels of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha mRNA expression, and the accumulation of leukocytes in the damaged segment of the spinal cord were significantly inhibited in animals receiving rhs-TM, but these effects were not observed following administration of rhs-TM pretreated with MAb R5G12 or MAb F2H5. Leukocytopenia and activated protein C all produced effects similar to those of rhs-TM. These findings suggest that rhs-TM prevents compression trauma-induced SCI by inhibiting leukocyte accumulation by reducing the expression of TNF-alpha mRNA and such therapeutic effects of rhs-TM could be dependent on its protein C activation capacity. Findings further suggest that thrombomodulin can be implicated not only in the coagulation system but in regulation of the inflammatory response.
Electrochemical Activities in Li[sub 2]MnO[sub 3] (2009)

is shown to be electrochemically active, with a maximum charge capacity of and a discharge capacity of at . A total of of Li can be extracted from , and the first cycle efficiency is regardless of state of charge. Larger charge-discharge capacity is obtained from materials with smaller particle size and larger amount of stacking faults. Composition and structural analyses indicate that Li are removed from both the Li and transitional metal layers of the material during charging. Results from X-ray-absorption fine-structure measurements suggest that the valence of Mn remains at during charging but is reduced during discharging. Charging is accompanied by gas generation: at , oxygen is the main gas detected, and the total amount accounts for of generation from . At an elevated temperature, amount of increases due to electrolyte decomposition. shows poor cycle performance, which is attributed to phase transformation and low charge-discharge efficiency during cycling. Low first-cycle efficiency, gas generation, and poor cycle performance limit the usage of in practical batteries.