gebhart/patrepeval huggingface dataset:
Understanding near-duplicate videos (2009)

Popular content in video sharing web sites (e.g., YouTube) is usually duplicated. Most scholars define near-duplicate video clips (NDVC) based on non-semantic features (e.g., different image/audio quality), while a few also include semantic features (different videos of similar content). However, it is unclear what features contribute to the human perception of similar videos. Findings of two large scale online surveys (N = 1003) confirm the relevance of both types of features. While some of our findings confirm the adopted definitions of NDVC, other findings are surprising. For example, videos that vary in visual content - by overlaying or inserting additional information - may not be perceived as near-duplicate versions of the original videos. Conversely, two different videos with distinct sounds, people, and scenarios were considered to be NDVC because they shared the same semantics (none of the pairs had additional information). Furthermore, the exact role played by semantics in relation to the features that make videos alike is still an open question. In most cases, participants preferred to see only one of the NDVC in the search results of a video search query and they were more tolerant to changes in the audio than in the video tracks. Finally, we propose a user-centric NDVC definition and present implications for how duplicate content should be dealt with by video sharing websites.
Metoprolol‐pridopidine drug–drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington's disease (2017)

As pridopidine is a metabolism-dependent inhibitor of CYP2D6, systemic levels of drugs metabolized by CYP2D6 may increase with chronic coadministration of pridopidine. Pridopidine can be administered without regard to food.
Spectrum of Neurological Deficits in Experimental CNS Ischemia (1982)

The sequence of events in focal cerebral ischemia has been difficult to study quantitatively in humans. Experimental investigation of these phenomena has been impeded because reproducible animals models that simulate human stroke are lacking. We have developed a rabbit spinal cord ischemia model that resembles human stroke patterns in many respects. Using this model, we have found that (1) brief ischemia produces completely reversible neurological deficits; (2) intermediate ischemic periods may produce transiently reversible deficits that later progress without further manipulation; (3) prolonged ischemia produces irreversible lesions in all animals. The model should be useful for studies of the pathophysiological mechanisms of CNS ischemia.
Steroidal Sapogenins. XLV. Effect of Side Chain Isomerism on Rate of Conversion to Pseudosapogenins<sup>2</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroidal Sapogenins. XLV. Effect of Side Chain Isomerism on Rate of Conversion to Pseudosapogenins2Monroe E. Wall and Samuel SerotaCite this: J. Am. Chem. Soc. 1957, 79, 24, 6481–6483Publication Date (Print):December 1, 1957Publication History Published online1 May 2002Published inissue 1 December 1957https://pubs.acs.org/doi/10.1021/ja01581a032https://doi.org/10.1021/ja01581a032research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Central Role for C1q/TNF-Related Protein 13 (CTRP13) in Modulating Food Intake and Body Weight (2013)

C1q/TNF-related protein 13 (CTRP13), a hormone secreted by adipose tissue (adipokines), helps regulate glucose metabolism in peripheral tissues. We previously reported that CTRP13 expression is increased in obese and hyperphagic leptin-deficient mice, suggesting that it may modulate food intake and body weight. CTRP13 is also expressed in the brain, although its role in modulating whole-body energy balance remains unknown. Here, we show that CTRP13 is a novel anorexigenic factor in the mouse brain. Quantitative PCR demonstrated that food restriction downregulates Ctrp13 expression in mouse hypothalamus, while high-fat feeding upregulates expression. Central administration of recombinant CTRP13 suppressed food intake and reduced body weight in mice. Further, CTRP13 and the orexigenic neuropeptide agouti-related protein (AgRP) reciprocally regulate each other's expression in the hypothalamus: central delivery of CTRP13 suppressed Agrp expression, while delivery of AgRP increased Ctrp13 expression. Food restriction alone reduced Ctrp13 and increased orexigenic neuropeptide gene (Npy and Agrp) expression in the hypothalamus; in contrast, when food restriction was coupled to enhanced physical activity in an activity-based anorexia (ABA) mouse model, hypothalamic expression of both Ctrp13 and Agrp were upregulated. Taken together, these results suggest that CTRP13 and AgRP form a hypothalamic feedback loop to modulate food intake and that this neural circuit may be disrupted in an anorexic-like condition.
Altered Golgi Localization of Core 2 β-1,6-N-Acetylglucosaminyltransferase Leads to Decreased Synthesis of Branched O-Glycans (1997)

Mucin type O-glycans with core 2 branches are distinct from nonbranched O-glycans, and the amount of core 2 branched O-glycans changes dramatically during T cell differentiation. This oligosaccharide is synthesized only when core 2 beta-1, 6-N-acetylglucosaminyltransferase (C2GnT) is present, and the expression of this glycosyltransferase is highly regulated. To understand how O-glycan synthesis is regulated by the orderly appearance of glycosyltransferases that form core 2 branched O-glycans, the subcellular localization of C2GnT was determined by using antibodies generated that are specific to C2GnT. The studies using confocal light microscopy demonstrated that C2GnT was localized mainly in cis to medial-cisternae of the Golgi. We then converted C2GnT to a trans-Golgi enzyme by replacing its Golgi retention signal with that of alpha-2,6-sialyltransferase, which resides in trans-Golgi. Chinese hamster ovary cells expressing wild type C2GnT and the chimeric C2GnT were then subjected to oligosaccharide analysis. The results obtained clearly indicate that the conversion of C2GnT into a trans-Golgi enzyme resulted in a substantial decrease of core 2 branched oligosaccharides. These results, taken together, strongly suggest that the predominance of core 2 branched oligosaccharides in those cells expressing C2GnT is due to the fact that C2GnT is located earlier in the Golgi than alpha-2,3-sialyltransferase that competes with C2GnT for the common substrate. Furthermore, alteration of Golgi localization renders the chimeric C2GnT much less efficient in synthesizing core 2 branched oligosaccharides, indicating the critical role of orderly subcellular localization of glycosyltransferases.
Real-time prediction of patient immune cell modulation during irreversible electroporation therapy (2019)

Immunotherapies have demonstrated limited efficacy in pancreatic ductal adenocarcinoma (PDAC) patients despite their success in treating other tumor types. This limitation is largely due to the relatively immunosuppressive environment surrounding the tumor. A focal ablative technique called irreversible electroporation (IRE) has been shown to modulate this environment, enhancing the efficacy of immunotherapy. One enhancing factor related to improved prognosis is a decrease in regulatory T cells (T<sub>reg</sub>). This decrease has been previously unpredictable for clinicians using IRE, who currently have limited real-time metrics for determining the activation of the patient's immune response. Here, we report that larger overall changes in output current are correlated with larger decreases in T cell populations 24 hours post-treatment. This result suggests that clinicians can make real-time decisions regarding optimal follow-up therapy based on the range of output current delivered during treatment. This capability could maximize the immunomodulating effect of IRE in synergy with follow-up immunotherapy. Additionally, these results suggest that feedback from a preliminary IRE treatment of the local tumor may help inform clinicians regarding the timing and choice of subsequent therapies, such as resection, immunotherapy, chemotherapy, or follow-up thermal or non-thermal ablation.
Measuring PV system series resistance without full IV curves (2014)

We present a method for measuring the series resistance of the PV module, string, or array that does not require measuring a full IV curve or meteorological data. Our method relies only on measurements of open circuit voltage and maximum power voltage and current, which can be readily obtained using standard PV monitoring equipment; measured short circuit current is not required. We validate the technique by adding fixed resistors to a PV circuit and demonstrating that the method can predict the added resistance. Relative prediction accuracy appears highest for smaller changes in resistance, with a systematic underestimation at larger resistances. Series resistance is shown to vary with irradiance levels with random errors below 1.5% standard deviation.
Robust Detection of Textured Contact Lenses in Iris Recognition Using BSIF (2015)

This paper considers three issues that arise in creating an algorithm for the robust detection of textured contact lenses in iris recognition images. The first issue is whether the accurate segmentation of the iris region is required in order to achieve the accurate detection of textured contact lenses. Our experimental results suggest that accurate iris segmentation is not required. The second issue is whether an algorithm trained on the images acquired from one sensor will well generalize to the images acquired from a different sensor. Our results suggest that using a novel iris sensor can significantly degrade the correct classification rate of a detection algorithm trained with the images from a different sensor. The third issue is how well a detector generalizes to a brand of textured contact lenses, not seen in the training data. This paper shows that a novel textured lens type may have a significant impact on the performance of textured lens detection.
Modular Artificial β-Cell System: A Prototype for Clinical Research (2008)

The modular design of the system allows for the robust testing of various sensors and pumps as well as feedback control, meal detection, predictive hypoglycemia alarms, and device-related algorithms to detect sensor or pump failure.
Single‐walled nanotube bucky paper and nanocomposite (2006)

Abstract A new processing method for the fabrication of single‐walled nanotube (SWNT)‐reinforced nanocomposites was developed to achieve uniform dispersion and high composition of the nanotubes in the nanocomposites. In this method, SWNTs were preformed as bucky paper by multi‐step dispersion and micro‐filtration of a suspension of nanotubes. The nanocomposites were then fabricated by infiltration of diluted epoxy resin through the bucky paper and hot pressing. The wetting of the nanocomposites was examined using scanning electron microscopy and atomic force microscopy. The results showed that the epoxy resin completely penetrated the bucky paper through the nanoporous structures. The results of dynamic mechanical analysis of the nanocomposites showed that the storage moduli of the nanocomposites increased by 200–250%. The tan δ curves indicated that the nanotubes had a strong influence on the damping properties of the nanocomposites. This processing technique is an effective method for fabricating nanocomposites with uniform dispersion and high composition of SWNTs. Copyright © 2006 Society of Chemical Industry
Familial Brachmann‐de Lange syndrome: Further evidence for autosomal dominant inheritance and review of the literature (1993)

We report on a mother and daughter with the Brachmann-de Lange syndrome which supports the view that in some families this disorder is due to autosomal dominant inheritance. A review of the literature concerning autosomal and recessive inheritance of this syndrome is presented.
A hierarchical evolutionary algorithm for multiobjective optimization in IMRT (2010)

The MOEA produces a diverse Pareto optimal set of plans that meet all dosimetric protocol criteria in a feasible amount of time. The final goal is to improve practical aspects of the algorithm and integrate it with a decision analysis tool or human interface for selection of the IMRT plan with the best possible balance of successful treatment of the target with low OAR dose and low risk of complication for any specific patient situation.
Protein–polymer therapeutics: a macromolecular perspective (2014)

The development of protein-polymer hybrids emerged several decades ago with the vision that their synergistic combination will offer macromolecular hybrids with manifold features to succeed as the next generation therapeutics. From the first generation of protein-polymer therapeutics represented by PEGylated proteins, the field has since advanced, reinforced by the progress in contemporary chemical techniques for designing polymeric scaffolds and protein engineering. Novel polymerization techniques that offer multifunctional strategies as well as a greater understanding of proteins and their biological behavior have both proven to be exceptional tools in the construction of these hybrid materials. In this review, we seek to summarize and highlight the recent progress in these semi-synthetic protein hybrids in terms of their preparation, design, resulting bioarchitectures and bioactivities for their intended bio-applications.
Microwave sintering of ceramics (2021)

Successful adaptation of microwave heating to the densification of ceramic materials require a marriage of microwave and materials technologies. Using an interdisciplinary team of microwave and materials engineers, we have successfully demonstrated the ability to density ceramic materials over a wide range of temperatures. Microstructural evolution during microwave sintering has been found to be significantly different from that observed in conventional sintering. Our results and those of others indicate that microwave sintering has the potential to fabricate components to near net shape with mechanical properties equivalent to hot pressed or hot isostatically pressed material. 6 refs., 11 figs.
Software for the analysis and visualization of deep mutational scanning data (2015)

dms_tools implements a statistically principled approach for the analysis and subsequent visualization of deep mutational scanning data.
Response of a Light Aircraft Under Gust Loads (2004)

This project presents work performed by the Institute of Aerospace Engineering, Brno University of Technology. The primary purpose of this work was to estimate the aeroelastic response of a light aircraft under gust loads. In the past, the gust response has been investigated using the Pratt - Walker formula. This formula is derived from the response of a rigid airplane to a discrete gust. However, the Pratt-Walker formula does not capture either the stochastic nature of continuous turbulence or the effects of structural flexibility. The analysis described here was performed using the advanced FEM software package MSC Nastran.
Parasitic Natural Regulatory Agents Attacking Musca domestica L. in Puerto Rico (1965)

Immature stages of Musca domestica L. were sampled in Puerto Rico during 1903 for the purpose of securing parasitic material for use in biological control work in California. Six hymenopterous parasites were discovered in more or less stable breeding sites. One undescribed species of Diapriidae, Trichopria sp., and five Pteromalidae, Spalangia endius Walker, Spalangia nigroaenea Curtis, Spalangia slomoxysiae Girault, Muscidifurax raptor Girault and Sanders, and Pachycrepoideus vindemmiae (Rond.) were involved. Parasitization at any given collection site ranged from 1.4 to 25 percent of viable pupae. The Central and West Central Sections of the Island showed highest parasite activity. The role of predators other than ants was thought to be of prime importance in natural control of the more advanced immature stages of houseflies.
Role of Nuclear Size in Cell Growth Initiation (1979)

Swiss 3T3 cells arrested in B0 (quiescent state) by reducing serum content of the medium all contain the same amount of DNA but vary in nuclear volume over approximately a twofold range. By use of flow microfluorimetry, scatterplots of nuclear volume versus DNA content were obtained in intervals after serum stimulation. The earliest cells to enter DNA synthesis were those with the largest nuclei, whereas cells with the smallest nuclei were among the latest. Regulation of cellular transit from G0 to the S phase was therefore, at least in part, deterministic, since all G0 cells did not have equal probabilities of entry into S at a given moment. All cells having the same nuclear volume did not initiate DNA synthesis at the same moment; therefore, factors other than nuclear volume must also influence this timing. Nuclear volume correlated with the maximum rate at which cells could enter S. The kinetic model of the cell cycle postulating a probabilistic event as solely responsible for entry into S thus appears too simple.
Principle and application of a thermal probe to reactive plasmas (2002)

A thermal probe for plasma diagnostics is introduced. The method is based upon measuring the equilibrium temperature of a conducting sphere as a function of its applied bias. The resulting temperature–voltage characteristic is processed using a theoretical model that accounts for charge and thermodynamic balance. The thermal probe is capable of detecting negative ions and shows sensitivity to certain chemical reactions. Measurements performed in Ar, Ar/SF6, and O2 show good agreement among the plasma parameters using thermal and Langmuir probes.
DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences (2007)

Microsatellites are ubiquitously present in eukaryotic genomes and are implicated as positive factors in evolution. At the nucleotide level, microsatellites undergo slippage events that alter allele length and base changes that interrupt the repetitive tract. We examined DNA polymerase errors within a [T](11) microsatellite using an in vitro assay that preferentially detects mutations other than unit changes. We observed that human DNA polymerase kappa (Pol kappa) inserts dGMP and dCMP within the [T](11) mononucleotide repeat, producing an interrupted 12-bp allele. Polymerase beta produced such interruptions at a lower frequency. These data demonstrate that DNA polymerases are capable of directly producing base interruptions within microsatellites. At the molecular level, expanded microsatellites have been implicated in DNA replication fork stalling. Using an in vitro primer extension assay, we observed sequence-specific synthesis termination by DNA polymerases within mononucleotides. Quantitatively, intense, polar pausing was observed for both pol kappa and polymerase alpha-primase within a [T](11) allele. A mechanism is proposed in which pausing results from DNA bending within the duplex stem of the nascent DNA. Our data support the concept of a microsatellite life-cycle, and are consistent with the models in which DNA sequence or secondary structures contributes to non-uniform rates of replication fork progression.
Anaerobic biodegradability of cellulose and hemicellulose in excavated refuse samples using a biochemical methane potential assay (1994)

Improved techniques are needed to predict potential methane generation from refuse buried in landfills. The Biochemical Methane Potential (BMP) test was used to measure the methane potential of ten refuse samples excavated from a Berkeley, CA, landfill. The test was conducted in 125-ml serum bottles containing phosphate-buffered medium and inoculated with anaerobically digested sewage sludge. Comparison of the measured BMP to the theoretical BMP calculated from measured cellulose and hemicellulose concentrations indicated that cellulose plus hemicellulose is not well correlated with the measured BMP. The average of the measured to theoretical BMP was 19.1% (range 0-53%, s.d. = 16.9%). Measured sulfate concentrations showed that sulfate was an insignificant electron sink in the samples tested. Once methane production from the refuse was complete, 0.072 g of Whatman no. 1 filter paper was added to two of the four serum bottles incubated for each sample. An average of 84.9% (s.d. = 2.5%) of the added filter paper was recovered as methane, suggesting that some cellulose and hemicellulose present in refuse is recalcitrant or otherwise not bioavailable.
Remote-scope promotion: clarified, rectified, and verified (2015)

Modern accelerator programming frameworks, such as OpenCL, organise threads into work-groups. Remote-scope promotion (RSP) is a language extension recently proposed by AMD researchers that is designed to enable applications, for the first time, both to optimise for the common case of intra-work-group communication (using memory scopes to provide consistency only within a work-group) and to allow occasional inter-work-group communication (as required, for instance, to support the popular load-balancing idiom of work stealing). We present the first formal, axiomatic memory model of OpenCL extended with RSP. We have extended the Herd memory model simulator with support for OpenCL kernels that exploit RSP, and used it to discover bugs in several litmus tests and a work-stealing queue, that have been used previously in the study of RSP. We have also formalised the proposed GPU implementation of RSP. The formalisation process allowed us to identify bugs in the description of RSP that could result in well-synchronised programs experiencing memory inconsistencies. We present and prove sound a new implementation of RSP that incorporates bug fixes and requires less non-standard hardware than the original implementation. This work, a collaboration between academia and industry, clearly demonstrates how, when designing hardware support for a new concurrent language feature, the early application of formal tools and techniques can help to prevent errors, such as those we have found, from making it into silicon.