gebhart/patrepeval huggingface dataset:
Web Services for Quality of Service Monitoring (2009)

In this paper we present an analysis on Policy and Charging Control (PCC) functions in all IP-based multimedia networks and identify the required functionality for quality of service (QoS) monitoring. The support of "Application-driven Quality of Service" (ADQ) Parlay X Web Service to reporting function in PCC is evaluated and improvements of ADQ interfaces are suggested without violating the interface functionality. The gateway which provides Parlay X interfaces for third party applications supports Session Initiation Protocol (SIP) towards the network. A new SIP event package is suggested to support monitoring of QoS provided on SIP sessions.
Predicting the Agitation-Induced Aggregation of Monoclonal Antibodies Using Surface Tensiometry (2015)

Adsorption of antibody therapeutics to air-liquid interfaces can enhance aggregation, particularly when the solution does not contain protective surfactant or when the surfactant is diluted as occurs during preparation of intravenous infusion bags. The ability to predict an antibody's propensity for interfacially mediated aggregation is particularly useful during product development to ensure the quality, potency, and safety of the therapeutic. To develop a predictive tool, we investigated the surface pressure and surface excess of a panel of 16 antibodies as well as determined their aggregation propensity at the air-liquid interface in an agitation stress model. Our data demonstrated that the initial rate of surface pressure increase upon antibody adsorption to the air-liquid interface strongly predicted the extent of agitation-induced aggregation. Other factors, including the hydrophobicity, equilibrium surface pressure, and interfacial concentration of an antibody, were not adequate predictors of its susceptibility to aggregation. In addition to developing a predictive tool, we extended the interfacial characterization to better understand the mechanisms of antibody aggregation at an air-liquid interface during agitation stress. We believe that the kinetics of antibody rearrangement and conformational change after adsorbing to the interface, leading to the development of attractive antibody-antibody interactions, dictated the extent of aggregation. Overall, our results demonstrate how surface pressure measurements can be implemented as a rapid screening tool for the identification of antibodies with a high propensity to aggregate upon adsorption to an air-liquid interface while also furthering our understanding of interfacially mediated protein aggregation.
Expression cloning of a human renal cDNA that induces high affinity transport of L-cystine shared with dibasic amino acids in Xenopus oocytes (1993)

A renal cDNA clone (rBAT) that induces system bo,+-like amino acid transport activity in Xenopus oocytes has recently been isolated (Bertran, J., Werner, A., Moore, M. L., Strange, G., Markovich, D., Biber, J., Testar, X., Zorzano, A., Palacín, and Murer, H. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 5601-5605). Here we show the isolation of a cDNA clone by screening a human kidney cortex cDNA library for expression of sodium-independent transport of L-[3H]arginine in Xenopus oocytes. The cRNA of this clone induces in oocytes, in addition to the uptake of L-arginine, that of L-[35S]cystine and L-[3H]leucine. Expressed uptake of these amino acids is mutually cis-inhibitable by the other 2 amino acids. Expressed uptake of L-cystine is saturable and shows an apparent Km in the micromolar range. All these characteristics resemble induction of system bo,+ related to rBAT in the oocytes. Human rBAT mRNA (approximately 2.5 kilobases) is found in kidney, small intestine (i.e., jejunum), pancreas, and liver. Human kidney poly(A)+ RNA (mRNA) induces sodium-independent uptake of L-cystine, L-arginine, and L-leucine in Xenopus oocytes. Hybrid depletion with an antisense oligonucleotide of the isolated clone greatly prevents (80-97%) human kidney mRNA-dependent induction of the uptake of these amino acids (i.e., L-cystine, L-arginine, and L-leucine). The isolated clone (2304 base pairs in length) contains a poly(A) tail and encodes a predicted 78.8-kDa protein which is 85 and 80% identical to the rabbit and rat rBAT, respectively. This predicted protein corresponds to a membrane glycoprotein, and contains six potential N-glycosylation sites which might be functional in the oocyte: [35S] methionine labeling of oocytes shows a specific band of 94 kDa in crude membranes of these human cRNA-injected oocytes; treatment of these oocytes with tunicamycin shifts the cRNA-specific translation product to approximately 72 kDa. We conclude that we have isolated a functional cDNA corresponding to human rBAT. The isolation of this human cDNA would lead to the study of the possible involvement of rBAT in human hyperaminoacidurias.
IX.—NEW BOOKS (1962)

IX.—NEW BOOKS Get access The World of Art. By PAUL WEISS. Southern Illinois University Press, 1961. Pp. 182. $4.50. DAVID POLE DAVID POLE Search for other works by this author on: Oxford Academic Google Scholar Mind, Volume LXXI, Issue 282, April 1962, Page 279, https://doi.org/10.1093/mind/LXXI.282.279 Published: 01 April 1962
Die Fehlerkosten (1970)

Die Fehlerkosten eines Gewebes ergeben sich aus der Multiplikation von Fehlerhäufigkeit und Fehlerpreis. Die Fehlerhäufigkeit eines Gewebes ist technologisch bedingt. Sie kann durch Überwachung des Fertigungsablaufes in gewissem Umfang verringert werden. Der Fehlerpreis hat eine technologische und eine marktabhängige Komponente.
A neurofuzzy approach for fault diagnosis in dynamic systems (2002)

A system structure based on fuzzy set models of neurons and networks is introduced. The aim is to provide a learning approach for pattern classification. The focus of the paper is on its application to fault diagnosis of dynamic systems viewed as a specific category of pattern classification. The main features of the system include: automatic rule generation; learning capability; processing time independent of the input space partition, if the number of inputs is fixed; and no need of process models if fault patterns are available. Simulation results concerning a seventh order, nonlinear time variant system are presented. The system successfully detected and diagnosed fifteen faults. Its response time in diagnosing suggests the feasibility in real-time applications.
Versuchsanordnung und Versuchsgeräte (1961)

Die im Rahmen dieser Arbeit besprochenen Versuche wurden im Brikettierungslaboratorium der Rheinisch-Westfälischen Technischen Hochschule Aachen durchgeführt. Die meisten Rohstoffe wurden als übliche Aufbereitungserzeugnisse angeliefert. Nur bei dem Waldhausenerz war eine Nachzerkleinerung auf die Korngröße unter 1 mm auf der Laboratorims-Scheibenmühle erforderlich.
The Texaco/UOP HF alkylation additive technology: Aerosolization reduction effects (1995)

This paper examines typical release conditions leading to aerosol formation in existing HF alkylation technology. The variables affecting aerosol formation in the mechanical and thermal breakup regimes are identified. The properties of these key variables are altered chemically using an additive to reduce aerosol formation for the entire operation envelop without degradation of alkylation efficiency. Small and large scale tests were conducted to experimentally verify the benefits of the additive in both the mechanical and thermal breakup regimes. This paper summarizes the findings of these experiments and presents a detailed method for estimating the release, droplet formation and dynamics and dispersion behavior of chemically reacting systems. This method is validated using the small and large scale data and is used to perform sensitivity analysis to assess the impact of storage temperature, pressure, composition, atmospheric and site conditions on aerosol and toxic hazard zone reduction.
Error Floor Compensation for LDPC Codes Using Concatenated Schemes (2012)

This paper quantitatively investigates the trade-offs in the compensation of error floor on iterative decoders. The characterization of iterative decoding systems prone to error floor at low noise is a great challenge as techniques based on software simulation are inadequate due to the extremely long simulation time required. We compare the BER performance as measured at very low BER using hardware accelerators and study the cost of compensation techniques in terms of hardware complexity and throughput. Specifically, techniques based on the use of diversity in LDPC decoders and the use of concatenated BCH-LDPC codes are considered and corresponding hardware optimizations are discussed. It is shown that an introduced synergy of error-floor compensation techniques achieves substantial coding gain up to 1 dB at low noise, not possible by conventional LDPC or BCH decoders. In addition, hardware reductions are achieved in the BCH subsystem, due to simple post-processing in the LDPC decoder.
Food Composition Data: Production, Management and Use (1992)

Food composition data: production, management, and use , Food composition data: production, management, and use , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
A compact PET detector array using wavelength shifting fibres (2003)

The basis for a design of a high-resolution PET imaging system, utilising a wavelength-shifting (WLS) fibre readout technique is presented here. Scintillation light is transported from the individual LSO pixels in the detector array through the WLS fibres to a multi-pixel hybrid photodiode (M-HPD). Each detector array consists of a number of 2/spl times/2/spl times/10 mm LSO crystals viewed by two orthogonal ribbons of WLS fibres. An array of as many as 30/spl times/31 crystals can thus be read-out by a single, small 61-pixel M-HPD tube. The design is both compact, inexpensive and suitable for application not only in the field of small-animal PET or in a dedicated PEM system, but could also operate in a combined PET/MRI system. Initial tests have shown that the signal level generated at the detector by a single 511 keV energy-deposit, is 20-25 photoelectrons. Separate tests have indicated that, at this signal-level, a resolving time of /spl sim/25 ns could be achievable.
Measurement of High Frequency Electro-Optic Coefficient in Ferroelectric Liquid Crystal Materials (1991)

Ferroelectric liquid crystals (FLC's) form the thermodynamically stable Smectic C* liquid crystalline phase that is non-centrosymmetric and has macroscopic polar order. The symmetry (C 2 ) implies that FLC materials can exhibit second order nonlinear properties such as the linear electro-optic(EO) effect and second harmonic generation (SHG). In most FLC's designed for optical modulation applications these nonlinearities are small 1,2 , but in principle could be made, large by specifically synthesizing liquid crystal molecules which self-assemble in such a way that functional groups with large microscopic hyperpolarizabilities, β's, are oriented along the polar axis. By adopting this approach to produce second order nonlinear material, the problems associated with processing organic single crystals are avoided. Furthermore, the flexibility of the liquid crystal technology can be used to design materials with specific refractive indices for phase matching purposes and waveguide design. Waveguides in this material system are particularly interesting as they allow a significant increase in optical propagation length with high electric field generation capability; both important attributes for nonlinear optical phenomena. Preliminary work has already been carried out on waveguide structures whose possibilities are numerous owing to the ability to successfully align FLC's on many different substrates (including Si) 3 .
Response of Human Thalamic Neurons to High-Frequency Stimulation (2014)

Thalamic deep brain stimulation (DBS) is an effective treatment for tremor, but the mechanisms of action remain unclear. Previous studies of human thalamic neurons to noted transient rebound bursting activity followed by prolonged inhibition after cessation of high frequency extracellular stimulation, and the present study sought to identify the mechanisms underlying this response. Recordings from 13 thalamic neurons exhibiting low threshold spike (LTS) bursting to brief periods of extracellular stimulation were made during surgeries to implant DBS leads in 6 subjects with Parkinson's disease. The response immediately after cessation of stimulation included a short epoch of burst activity, followed by a prolonged period of silence before a return to LTS bursting. A computational model of a population of thalamocortical relay neurons and presynaptic axons terminating on the neurons was used to identify cellular mechanisms of the observed responses. The model included the actions of neuromodulators through inhibition of a non-pertussis toxin sensitive K(+) current (I(KL)), activation of a pertussis toxin sensitive K(+) current (I(KG)), and a shift in the activation curve of the hyperpolarization-activated cation current (I(h)). The model replicated well the measured responses, and the prolonged inhibition was associated most strongly with changes in I(KG) while modulation of I(KL) or I(h) had minimal effects on post-stimulus inhibition suggesting that neuromodulators released in response to high frequency stimulation are responsible for mediating the post-stimulation bursting and subsequent long duration silence of thalamic neurons. The modeling also indicated that the axons of the model neurons responded robustly to suprathreshold stimulation despite the inhibitory effects on the soma. The findings suggest that during DBS the axons of thalamocortical neurons are activated while the cell bodies are inhibited thus blocking the transmission of pathological signals through the network and replacing them with high frequency regular firing.
What Does Deep Learning See? Insights From a Classifier Trained to Predict Contrast Enhancement Phase From CT Images (2018)

As a whole, voxel-level visualizations and visualizations of the imaging features that activate shallow network layers are powerful techniques to identify features that deep learning models use when performing prediction.
Innate Imprinting by the Modified Heat-Labile Toxin of <i>Escherichia coli</i> (LTK63) Provides Generic Protection against Lung Infectious Disease (2004)

In a healthy individual, the lung contains few lymphoid cells. However, amplified immune responses, as exemplified during lung infection, can cause extensive tissue damage. We have previously demonstrated that one lung infection modulates the immunopathological outcome to a subsequent unrelated pathogen. Mimicking heterologous immunity may provide a means of enhancing both innate and acquired immunity. We now show that prior lung administration of a modified heat-labile toxin from Escherichia coli (LTK63) enhances immunity to respiratory syncytial virus, influenza virus, and the fungus Cryptococcus neoformans. Treatment with LTK63 decreased lung inflammation and tissue damage and improved the ability to resolve the infection. APCs expressing the activation markers MHC class II, CD80, and CD40 increased in number in the lung. LTK63 treatment increased the pathogen-specific IgA response in the nasal mucosa and simultaneously decreased inflammatory cytokine production (IFN-gamma and TNF-alpha) after infection. The number of activated CD8(+)CD44(+) T cells and the respiratory syncytial virus- or influenza-specific CD8-proliferative responses increased, although the total inflammatory infiltrate was reduced. LTK63 treatment matured lung APCs (LTK63 prevented efficient presentation of whole OVA to DO11.10 cells, whereas OVA peptide presentation was unaffected), enhanced immunity in both a Th1 and Th2 environment, was long lasting, and was not pathogen or host strain specific; the protective effects were partially independent of T and B cells. Innate imprinting by toxin-based immunotherapeutics may provide generic protection against infectious disease in the lung, without the need for coadministered pathogen-specific Ag.
Hepatitis C: an update (2001)

Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. While current therapeutic options for hepatitis C are limited, recent progress in the understanding of the biology of HCV led to the identification of novel targets for antiviral intervention. In addition, molecular and immunotherapeutic strategies to inhibit HCV replication or gene expression and to enhance the cellular immune response against HCV are being explored. These and other novel antiviral strategies may eventually complement existing therapeutic modalities. Here, we briefly review current concepts of the epidemiology, molecular virology, pathogenesis, natural history, diagnosis, therapy, and prevention of hepatitis C.
Combined road prediction and target tracking in collision avoidance (2004)

Detection and tracking of other vehicles and lane geometry will be required for many future intelligent driver assistance systems. By integrating the estimation of these two features into a single filter, a more optimal utilization of the available information can be achieved. For example, it is possible to improve the lane curvature estimate during bad visibility by studying the motion of other vehicles. This paper derives and evaluates various approximations that are needed in order to deal with the non-linearities that are introduced by such an approach.
Toward Safer Processes for C−C Biaryl Bond Construction: Catalytic Direct C−H Arylation and Tin-Free Radical Coupling in the Synthesis of Pyrazolophenanthridines (2009)

A series of pyrazolo[1,5-f]phenanthridine derivatives has been efficiently synthesized by a short, straightforward sequence. A tandem amine-exchange/heterocyclization of enaminones was successfully applied to the regioselective preparation of 1,5-diarylpyrazole intermediates with structure resemblance to relevant nonsteroidal anti-inflammatory drugs such as celecoxib or tepoxalin. The final key step, cyclization by intramolecular biaryl bond formation, was accomplished by two alternative methodologies: radical coupling and catalytic direct arylation via C-H activation. The scope and limitations of the two methodologies have been explored and their complementariness has been established. In addition, polymer-supported heterogeneous catalysts have been compared with homogeneous analogues. In the radical process, toxic tin derivatives have been avoided in order to employ environmentally safer protocols.
Tissue‐specific DNA methylation patterns of the rat glial fibrillary acidic protein gene (1994)

The glial fibrillary acidic protein (GFAP) is an intermediate filament protein, specific of the cytoskeleton of astrocytes in the central nervous system. In the present work, as a preliminary step to the study of glial-specific gene expression, we cloned the rat GFAP gene, and we report the sequence of 1.9 kb of the 5' flanking region, exon 1, and the majority of the first intron. By digestion with methylation-sensitive restriction enzymes followed by Southern blot analysis, the methylation status of various CpG sites was examined in this genomic segment. We tested whether structural modification of the GFAP gene, such as DNA methylation, could be related to its tissue-specific transcriptional activity. Therefore, we compared a GFAP-expressing cell population (primary culture of astroglial cells), a mixed population of GFAP-expressing and -nonexpressing cells (adult rat cerebral hemispheres), and a GFAP-nonexpressing tissue (liver). In the 5' flanking region we identified a CpG site at position -1176 whose level of methylation is inversely correlated to GFAP expression. In primary cultured astrocytes, 75% of the GFAP gene alleles were demethylated at this site, while the corresponding value obtained for the cerebral hemispheres was 45%, and for liver only 9%. On the basis of the sequence data, a CpG-rich region (putative CpG island) was identified extending from -38 to +347 and overlapping 80% of the first exon. HhaI and HpaII sites located in the putative CpG island showed a relatively high level of methylation in all the cell populations examined, and did not show any clear correlation with the level of GFAP gene expression or with the methylation status of the -1176 site. Further in vivo developmental studies and in vitro differentiation studies are necessary to better understand the functional differences of the various methylatable CpG sites in the 5' end of the GFAP gene.
Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. (2003)

The objectives of this study were to determine whether differences in the size and composition of coarse (2.5-10 micro m), fine (< 2.5 microm), and ultrafine (< 0.1 microm) particulate matter (PM) are related to their uptake in macrophages and epithelial cells and their ability to induce oxidative stress. The premise for this study is the increasing awareness that various PM components induce pulmonary inflammation through the generation of oxidative stress. Coarse, fine, and ultrafine particles (UFPs) were collected by ambient particle concentrators in the Los Angeles basin in California and used to study their chemical composition in parallel with assays for generation of reactive oxygen species (ROS) and ability to induce oxidative stress in macrophages and epithelial cells. UFPs were most potent toward inducing cellular heme oxygenase-1 (HO-1) expression and depleting intracellular glutathione. HO-1 expression, a sensitive marker for oxidative stress, is directly correlated with the high organic carbon and polycyclic aromatic hydrocarbon (PAH) content of UFPs. The dithiothreitol (DTT) assay, a quantitative measure of in vitro ROS formation, was correlated with PAH content and HO-1 expression. UFPs also had the highest ROS activity in the DTT assay. Because the small size of UFPs allows better tissue penetration, we used electron microscopy to study subcellular localization. UFPs and, to a lesser extent, fine particles, localize in mitochondria, where they induce major structural damage. This may contribute to oxidative stress. Our studies demonstrate that the increased biological potency of UFPs is related to the content of redox cycling organic chemicals and their ability to damage mitochondria.
Full-field and single-shot quantitative phase microscopy using dynamic speckle illumination (2011)

We developed an off-axis quantitative phase microscopy that works for a light source with an extremely short spatial coherence length in order to reduce the diffraction noise and enhance the spatial resolution. A dynamic speckle wave whose coherence length is 440 nm was used as an illumination source. To implement an off-axis interferometry for a source of low spatial coherence, a diffraction grating was inserted in the reference beam path. In doing so, an oblique illumination was generated without rotation of the wavefront, which leads to a full-field and single-shot phase recording with improved phase sensitivity of more than a factor of 10 in comparison with coherent illumination. The spatial resolution, both laterally and axially, and the depth selectivity are significantly enhanced due to the wide angular spectrum of the speckle wave. We applied our method to image the dynamics of small intracellular particles in live biological cells. With enhanced phase sensitivity and speed, the proposed method will serve as a useful tool to study the dynamics of biological specimens.