gebhart/patrepeval huggingface dataset:
Efficient Dynamic Fixed-Point Quantization of CNN Inference Accelerators for Edge Devices (2019)

This paper presents a dynamic fixed-point quantization flow. Different bit-width configurations of features, weights, and partial sums can be evaluated comprehensively over the state-of-the-art convolutional neural networks. The proposed quantization scheme simplifies the hardware design for on-device inference with the help of our analysis framework. The experiment results show that the energy consumption can be improved by up to 29.55% with little accuracy degradation by representing features/weights of 8 bits, and partial sums of 16 bits.
The Evolution of Pd∕Sn Catalytic Surfaces in Electroless Copper Deposition (2011)

This article was published in the Journal of the Electrochemical Society [© Electrochemical Society] and the definitive version is available at: http://dx.doi.org/10.1149/1.3536543
Ring-opening polymerizations of lactone and epoxide initiated with aluminum complexes of substituted tetraphenylporphyrins. Molecular design of highly active initiators (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing-opening polymerizations of lactone and epoxide initiated with aluminum complexes of substituted tetraphenylporphyrins. Molecular design of highly active initiatorsHiroshi Sugimoto, Takuzo Aida, and Shohei InoueCite this: Macromolecules 1990, 23, 11, 2869–2875Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/ma00213a009https://doi.org/10.1021/ma00213a009research-articleACS PublicationsRequest reuse permissionsArticle Views494Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Olanzapine for Nausea and Vomiting (2010)

Nausea and vomiting are often encountered in palliative care patients. Multiple medications are available to provide relief. However, several drug combinations are usually used to treat emesis. Current research has identified several receptors that trigger nausea and vomiting, hence the difficulty of using only 1 medication to provide relief. Olanzapine is a drug approved for treatment of schizophrenia and mania. It blocks multiple neurotransmitters dopaminergic, serotonergic, adrenergic (alpha(1)), histaminergic, and muscarinic receptors. Most of these receptors are also involved in causing emesis. Studies have shown that olanzapine could be used to treat nausea and vomiting with promising results.
Field induced shape and work function modification for the ZrO/W(100) Schottky cathode (2010)

The origin of the frequently observed long and short term current drifts after a change in the extractor voltage for the ZrO/W(100) Schottky cathode has been investigated. It has been found that a reversible, field dependent change in the equilibrium work function and shape of the cathode end form occurs at the typical operating temperature of 1800 K. The shape change results in three distinct geometric end form shapes. Although these end forms have been observed previously [L. W. Swanson and G. A. Schwind, in Handbook of Charged Particle Optics, 2nd ed., edited by J. Orloff (CRC, New York, 2008), Chap. 1, p. 1; S. Fujita, T. R. Wells, W. Ushio, H. Sato, and M. M. El-Gomati, J. Microsc. 235, 215 (2010); M. S. Bronsgeest and P. Kruit, J. Vac. Sci. Technol. B 27, 2524 (2009)], the purpose of this study is to elucidate the operating conditions under which these changes occur and the associated changes in emission properties. Emitters in the radii range 200–900 nm were investigated over the typical current density operating range employed in most electron probe forming systems. A correlation between work function and electric field has been found, which can be explained by a reversible, field induced change in the ZrO equilibrium coverage in the high field region of the emitter, thereby causing a change in the work function. It is believed that these field induced changes in the equilibrium work function and emitter shape at 1800 K explain the short and long term drifts observed after a change in extractor voltage.
Elevated activities of serum (α(1→3)-L-fucosyltransferase in human cancer (1989)

In the present investigation, we describe that α(1→3)-L-fucosyltransferase activity is significantly elevated in serum samples from a large variety of patients with cancer and that the elevation correlates strongly with the clinical stages and to the size of primary tumor in gastric and lung cancer
Predominance of multi-resistant gram-negative bacteria colonizing chronic lower limb ulcers (CLLUs) at Bugando Medical Center (2014)

There is high prevalence of ESBL and MRSA isolates in surgical wards at BMC. We recommend infection control and antibiotic stewardship programs in these wards to minimize spread of multi-resistant organisms.
A 5.9µm-pixel 2D/3D image sensor with background suppression over 100klx (2013)

A 2D/3D image sensor with reconfigurable pixel array and column-level background suppression scheme is presented for high resolution outdoor imaging. The proposed pixel array employs pixel binning and superresolution techniques for adaptable resolution. The sensor achieved a 5.9µm pixel and was able to capture full resolution outdoor depth images under daylight over 100klx.
Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency (2015)

Measurement of 16OHP and 11OHP along with 17OHP and 21dF by liquid chromatography/tandem mass spectrometry might comprise a biomarker panel to accurately diagnose all forms of 21OHD.
Efficacy of Rhizobacteria as biological control agents of grassy weeds (1997)

Deleterious rhizobacteria (DRB) associated with the roots and rhizosphere of weeds have tremendous potential as biological weed control agents.Screening and evaluation of the efficacy of DRB for biological control of downy brome (Bromus tectorum), green foxtail (Setaria viridis), and wild oats (Avena fatua) was conducted and methods for optimizing biocontrol activity were determined.Several hundred isolates of DRB were screened, with more than 100 isolates with 280% suppression of root growth in laboratory bioassays showing weed inhibitory properties.An increase in root growth suppression was demonstrated when unfiltered bacterial broth was incorporated into agar, compared to cell-free culture filtrate alone.Nutritional factors also played a role in enhancing biocontrol activity.Increases in root and shoot suppression were demonstrated when selected DRB isolates were grown in a nutrient broth, compared to a minimal salts broth.Specific requirements in the nutritional environment of the bacterial culture medium and the effect these changes have on propagule yield, efficacy and stability will have a significant impact on the potential of a biological control agent and its success as a commercial product.
Characterization of etch rate and anisotropy in the temperature-controlled chemically assisted ion beam etching of GaAs (1990)

Independent adjustment of etch rate and sidewall profiles in chemically assisted ion beam etching (CAIBE) of GaAs is demonstrated by controlling the temperature of the sample. GaAs etch rate data as a function of sample temperature, ion beam flux, and reactive gas flow is presented for CAIBE using a 500 eV argon ion beam and molecular chlorine. At a constant etch rate of 0.5 μm/min, etch profiles ranging from vertical to crystallographically faceted are obtained. This demonstrated flexibility, combined with the inherent reproducibility of dry etching, make CAIBE an attractive choice for processing advanced semiconductor devices. To illustrate the range of capabilities available with temperature-controlled CAIBE, etched-facet laser structures, self-aligned mesas and fine tips suitable for field-emitting devices are fabricated.
TREAT: a bioinformatics tool for variant annotations and visualizations in targeted and exome sequencing data (2011)

TREAT is freely available to non-commercial users as either a stand-alone annotation and visualization tool, or as a comprehensive workflow integrating sequencing alignment and variant calling. The executables, instructions and the Amazon Cloud Images of TREAT can be downloaded at the website: http://ndc.mayo.edu/mayo/research/biostat/stand-alone-packages.cfm.
Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition (2011)

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease. An amino terminal cluster of constitutively phosphorylated residues, serines 860, 910, 935, 955, and 973, appears to be biologically relevant. Phosphorylation of serines 910 and 935 is regulated in response to LRRK2 kinase activity and is responsible for interaction with 14-3-3 and maintaining LRRK2 in a non-aggregated state. We examined the phosphorylation status of two other constitutive phosphorylation sites, serines 955 and 973. Treatment of LRRK2 expressing cells with the selective LRRK2 inhibitor LRRK2-IN1 revealed that, like Ser910/Ser935, phosphorylation of Ser955 and Ser973 is disrupted by acute inhibition of LRRK2 kinase activity. Additionally, phosphorylation of Ser955 and 973 is disrupted in the context of several Parkinson's disease associated mutations [R1441G/C, Y1699C, and I2020T]. We observed that modification of Ser973 is dependent on the modification of Ser910/Ser935. Ser955Ala and Ser973Ala mutations do not induce relocalization of LRRK2; however, all phosphomutants exhibited similar localization patterns when exposed to LRRK2-IN1. We conclude that the mechanisms of regulation of Ser910/935/955/973 phosphorylation are similar and physiologically relevant. These sites can be utilized as biomarkers for LRRK2 activity as well as starting points for the elucidation of upstream and downstream enzymes that regulate LRRK2.
Intermodulation in heterojunction bipolar transistors (1992)

The modeling of small-signal intermodulation distortion (IMD) in heterojunction bipolar transistors (HBTs) is examined. The authors show that IMD current generated in the exponential junction is partially canceled by IMD current generated in the junction capacitance, and that this phenomenon is largely responsible for the unusually good IMD performance of these devices. Thus, a nonlinear model of the HBT must characterize both nonlinearities accurately. Finally, the authors propose a nonlinear HBT model suitable for IDM calculations, show how to measure its parameters, and verify its accuracy experimentally.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Controlling generic visualization environments using handheld devices and natural feature tracking (2011)

This paper presents a framework that enables human-machine interaction with generic visualization devices using personal consumer electronics equipment and scaleinvariant feature matching image processing techniques. The proposed implementation tracks the location and orientation of a generic mobile device equipped with an onboard camera and makes it possible to develop innovative and affordable user interfaces. The framework matches the time-variant features extracted from the frame buffer of a 2D or 3D scene with the features extracted from the camera-generated images that contain the displayed scene in order to derive positioning information with six degrees of freedom. Experimental results regarding precision, accuracy and latency confirmed the applicability of this solution as both an alternative user interface for desktop applications as well as an affordable method to support interaction with virtual environments.
Ultra-thin benzocyclobutene bonding of III–V dies onto SOI substrate (2005)

The bonding of InP/InGaAsP heterostructures dies onto an SOI substrate is reported. Bonding layer thicknesses down to 200 nm were reproducibly achieved. Bonding was achieved both on unprocessed SOI substrates as on processed SOI substrates containing high index contrast waveguides.
Electrostatic film actuator with a large vertical displacement (1992)

A microvalve actuator driven by electrostatic force and suitable for a rarefied gas flow control system is proposed. The actuator consists of a pair of planar electrodes sandwiching a conductive film. The film has an S-shaped bend in the middle. The S-bend moves back and forth as voltage is applied between the film and each of the electrodes alternately. The actuator makes possible the large valve seat lift that is necessary to allow a certain amount of gas flow. A macro model of the actuator allowed investigation of motion in the system. A film 5- mu m thick and 12 mm wide was successfully operated between electrodes separated by 2.5 mm. The observed propagation speed was 4.0 m/s when the applied voltage was 150 V.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Building Content Distribution Network: A Solution to Achieve QoS on Internet (2011)

Content Distribution Network (CDN) involves several technologies, rather than just one technology working alone. CDN is another method to provide Quality of Service (QoS) to different applications and deliver different types of media content to end-users over the Internet. Since it is important to improve Internet performance in recent years, CDN has been an approach providing better Internet services. There are a number of technologies and components included in the CDN, and also several challenges needed to be considered for its performance. This paper presents basic components of CDN and summarizes the challenges and issues analyzing the development of CDNs towards QoS.
trans-Stilbene Aggregates in Microheterogeneous Media: Evidence for a Chiral Cyclic Supramolecular Unit (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTtrans-Stilbene Aggregates in Microheterogeneous Media: Evidence for a Chiral Cyclic Supramolecular UnitXuedong Song, Cristina Geiger, Uwe Leinhos, Jerry Perlstein, and David G. WhittenCite this: J. Am. Chem. Soc. 1994, 116, 22, 10340–10341Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/ja00101a080https://doi.org/10.1021/ja00101a080research-articleACS PublicationsRequest reuse permissionsArticle Views180Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Heparin-binding EGF-like growth factor contributes to reduced glomerular filtration rate during glomerulonephritis in rats (2000)

Heparin-binding epidermal growth factor-like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, is expressed during inflammatory and pathological conditions. We have cloned the rat HB-EGF and followed the expression of HB-EGF in rat kidneys treated with anti- glomerular basement membrane (anti-GBM) antibody (Ab) to induce glomerulonephritis (GN). We observed glomerular HB-EGF mRNA and protein within 30 minutes of Ab administration and showed by in situ hybridization that glomerular HB-EGF mRNA expression was predominantly in mesangial and epithelial cells. Expression of HB-EGF correlated with the onset of decreased renal function in this model. To test the direct effect of HB-EGF on renal function, we infused the renal cortex with active rHB-EGF, prepared from transfected Drosophila melanogaster cells. This treatment induced a significant decrease in single nephron GFR (SNGFR), single nephron plasma flow, and glomerular ultrafiltration coefficient and an increase in the glomerular capillary hydrostatic pressure gradient. In addition, anti-HB-EGF Ab administered just before anti-GBM Ab blocked the fall in SNGFR and GFR at 90 minutes without any change in the glomerular histologic response. These studies suggest that HB-EGF expressed early in the anti-GBM Ab GN model contributes to the observed acute glomerular hemodynamic alterations.
Suppression of the Cerebral Vasospastic Actions of Oxyhemoglobin by Ascorbic Acid (1991)

Abstract Oxyhemoglobin (Oxy-Hb) produced a concentration-dependent contraction of monkey, dog, and bovine cerebral artery strips. Treatment of Oxy-Hb with ascorbic acid suppressed the ability of Oxy-Hb to contract the arteries, especially in the monkey arteries. The ability of intracisternally applied Oxy-Hb to constrict the basilar artery in anesthetized dogs was diminished when Oxy-Hb was treated previously with ascorbic acid (AsA-Hb). The contraction caused by Oxy-Hb was suppressed by treatment with indomethacin and aspirin in isolated bovine cerebral arteries. Endothelium-dependent relaxations elicited by substance P and relaxations induced by stimulation of the vasodilator nerves with nicotine were suppressed by treatment with Oxy-Hb and AsA-Hb; however, the inhibitory effect of AsA-Hb was markedly less. Oxy-Hb attenuated nitroglycerin-induced relaxations in a dose-dependent fashion, whereas AsA-Hb in concentrations up to 1.6 x 10-5 M did not significantly influence the relaxations. It is concluded that incubation of Oxy-Hb with ascorbic acid alters markedly the biological activity of Oxy-Hb; the vasoconstrictor activity is suppressed, and the ability to diminish vasodilator actions is minimized. These findings provide a rationale for the use of ascorbic acid in cisternal irrigation to prevent the development of cerebral vasospasm after a subarachnoid hemorrhage.
Comparative Selectivity and Specificity of the Proteasome Inhibitors BzLLLCOCHO, PS-341, and MG-132 (2006)

The 26S proteasome is a multicatalytic protease responsible for regulated intracellular protein degradation. Its function is mediated by three main catalytic activities: (a) chymotrypsin-like (CT-L), (b) trypsin-like, and (c) peptidylglutamyl peptide hydrolysing (PGPH). Proteasome inhibition is an emerging therapy for many cancers and is a novel treatment for multiple myeloma. Here, we profile the contributions of the three catalytic activities in multiple myeloma cell lines and compare the specificity and cytotoxicity of the novel proteasome inhibitor BzLLLCOCHO and inhibitors PS-341 (Velcade, bortezomib) and MG-132. Using fluorogenic substrates and an active site-directed probe specific for proteasome catalytic subunits, we show differential subunit specificity for each of the inhibitors. Addition of BzLLLCOCHO strongly inhibited all three catalytic activities, treatment with PS-341 completely inhibited CT-L and PGPH activities, and treatment with MG-132 resulted in weak inhibition of the CT-L and PGPH activities. Multiple myeloma cells were more sensitive to induction of apoptosis by PS-341 and MG-132 than BzLLLCOCHO. This study emphasizes the need for further investigation of the effects of these compounds on gene and protein expression in the cell to allow for the development of more specific and targeted inhibitors.
SAR processing with non-linear FM chirp waveforms. (2006)

Nonlinear FM (NLFM) waveforms offer a radar matched filter output with inherently low range sidelobes. This yields a 1-2 dB advantage in Signal-to-Noise Ratio over the output of a Linear FM (LFM) waveform with equivalent sidelobe filtering. This report presents details of processing NLFM waveforms in both range and Doppler dimensions, with special emphasis on compensating intra-pulse Doppler, often cited as a weakness of NLFM waveforms.
Biological activities of fibroblast growth factor-2 in the adult myocardium (2002)

Fibroblast growth factor-2 (FGF-2) is a potent regulator of many cellular functions and phenomena, including cell proliferation, differentiation, survival, adhesion, migration, motility and apoptosis, and processes such as limb formation, wound healing, tumorigenesis, angiogenesis, vasculogenesis and blood vessel remodeling. In the adult myocardium, FGF-2 is expressed by various cell types, including cardiomyocytes, fibroblasts and smooth muscle cells. The biological effects of FGF-2 in the myocardium are mediated by the high-affinity tyrosine kinase receptor FGFR-1, the major FGF receptor in the heart. Here, we give an overview of current insights into the multiple roles of FGF-2 in the myocardium, as they pertain to two basic phenomena: ischemia-reperfusion injury and cardiac hypertrophy. The first category includes roles for FGF-2 in cardioprotection, the inflammatory response, angiogenesis and vascular remodeling, while the second includes myocyte hypertrophy, fibrosis, and gap junction functioning (conduction). Given the strong evidence for FGF-2 as both a cardioprotective and angiogenic agent, the therapeutic potential of FGF-2 in the ischemic myocardium is discussed.
GDNF and the RET Receptor in Cancer: New Insights and Therapeutic Potential (2019)

The Glial cell line-derived neurotrophic Family Ligands (GFL) are soluble neurotrophic factors that are required for development of multiple human tissues, but which are also important contributors to human cancers. GFL signaling occurs through the transmembrane RET receptor tyrosine kinase, a well-characterized oncogene. GFL-independent RET activation, through rearrangement or point mutations occurs in thyroid and lung cancers. However, GFL-mediated activation of wildtype RET is an increasingly recognized mechanism promoting tumor growth and dissemination of a much broader group of cancers. RET and GFL expression have been implicated in metastasis or invasion in diverse human cancers including breast, pancreatic, and prostate tumors, where they are linked to poorer patient prognosis. In addition to directly inducing tumor growth in these diseases, GFL-RET signaling promotes changes in the tumor microenvironment that alter the surrounding stroma and cellular composition to enhance tumor invasion and metastasis. As such, GFL RET signaling is an important target for novel therapeutic approaches to limit tumor growth and spread and improve disease outcomes.