gebhart/patrepeval huggingface dataset:
Pharmacology of 5'-esters of 1-beta-D-arabinofuranosylcytosine. (1977)

Sample retrieval remains a central problem in the cre-ative process of making electronic dance music. This pa-per describes the findings from a series of interview ses-sions involving users working creatively with electronic music. We conducted in-depth interviews with expert users on location at the Red Bull Music Academies in 2014 and 2015. When asked about their wishes and expectations for future technological developments in interfaces, most par-ticipants mentioned very practical requirements of storing and retrieving files. A central aspect of the desired systems is the need to provide increased flow and unbroken periods of concentration and creativity. From the interviews, it becomes clear that for Creative MIR, and in particular, for music interfaces for creative ex-pression, traditional requirements and paradigms for music and audio retrieval differ to those from consumer-centered MIR tasks such as playlist generation and recommendation and that new paradigms need to be considered. Despite all technical aspects being controllable by the experts them-selves, searching for sounds to use in composition remains a largely semantic process. From the outcomes of the in-terviews, we outline a series of possible conclusions and areas and pose two research challenges for future develop-ments of sample retrieval interfaces in the creative domain.
SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling (2000)

The SOCS proteins are induced by several cytokines and are involved in negative feedback loops. Here we demonstrate that in 3T3-L1 adipocytes, insulin, a hormone whose receptor does not belong to the cytokine receptor family, induces SOCS-3 expression but not CIS or SOCS-2. Using transfection of COS-7 cells, we show that insulin induction of SOCS-3 is enhanced upon Stat5B expression. Moreover, Stat5B from insulin-stimulated cells binds directly to a Stat element present in the SOCS-3 promoter. Once induced, SOCS-3 inhibits insulin activation of Stat5B without modifying the insulin receptor tyrosine kinase activity. Two pieces of evidence suggest that this negative regulation likely results from competition between SOCS-3 and Stat5B binding to the same insulin receptor motif. First, using a yeast two-hybrid system, we show that SOCS-3 binds to the insulin receptor at phosphotyrosine 960, which is precisely where Stat5B binds. Second, using confocal microscopy, we show that insulin induces translocation of SOCS-3 from an intracellular compartment to the cell membrane, leading to colocalization of SOCS-3 with the insulin receptor. This colocalization is dependent upon phosphorylation of insulin receptor tyrosine 960. Indeed, in cells expressing an insulin receptor mutant in which tyrosine 960 has been mutated to phenylalanine, insulin does not modify the cellular localization of SOCS-3. We have thus revealed an insulin target gene of which the expression is potentiated upon Stat5B activation. By inhibiting insulin-stimulated Stat5B, SOCS-3 appears to function as a negative regulator of insulin signaling.
Object-oriented hypermedia support systems (2002)

The autors explore the integration of three software technologies, hyper-navigational user control, multimedia, and object-orientation, to develop more responsive support systems. The merger of these technologies gives rise to a visionary hybrid system type referred to as hypermedia support systems (HSSs). HSSs promote higher levels of understanding because users can interact with rich data types-video, audio, text, and graphics-and approach information from different points of view. Hyper-navigation parallels the associative memory model proposed by cognitive psychologists to represent the human thinking process. As such, hyper-navigation gives users the ability to access information in an intuitive and flexible manner, thereby supporting even unstructured problem solving. Incorporating multimedia technology further increases responsiveness by combining different media elements for display and control from a PC. An object-oriented approach coupled with special objects called software topics provides an integrating mechanism for HSSs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Item Recommendation in Collaborative Tagging Systems (2011)

Along with the new opportunities introduced by Web 2.0 and collaborative tagging systems, several challenges have to be addressed too, notably, the problem of information overload. Recommender systems are among the most successful approaches for increasing the level of relevant content over the “noise.” Traditional recommender systems fail to address the requirements presented in collaborative tagging systems. This paper considers the problem of item recommendation in collaborative tagging systems. It is proposed to model data from collaborative tagging systems with three-mode tensors, in order to capture the three-way correlations between users, tags, and items. By applying multiway analysis, latent correlations are revealed, which help to improve the quality of recommendations. Moreover, a hybrid scheme is proposed that additionally considers content-based information that is extracted from items. Experimental comparison, using data from a real collaborative tagging system (Last.fm), against both recent tag-aware and traditional (non tag aware) item recommendation algorithms indicates significant improvements in recommendation quality. Moreover, the experimental results illustrate the advantage of the proposed hybrid scheme.
Molecules targeting the androgen receptor (AR) signaling axis beyond the AR‐Ligand binding domain (2018)

Prostate cancer (PCa) is the second most common cause of cancer-related mortality in men in the United States. The androgen receptor (AR) and the physiological pathways it regulates are central to the initiation and progression of PCa. As a member of the nuclear steroid receptor family, it is a transcription factor with three distinct functional domains (ligand-binding domain [LBD], DNA-binding domain [DBD], and transactivation domain [TAD]) in its structure. All clinically approved drugs for PCa ultimately target the AR-LBD. Clinically active drugs that target the DBD and TAD have not yet been developed due to multiple factors. Despite these limitations, the last several years have seen a rise in the discovery of molecules that could successfully target these domains. This review aims to present and comprehensively discuss such molecules that affect AR signaling through direct or indirect interactions with the AR-TAD or the DBD. The compounds discussed here include hairpin polyamides, niclosamide, marine sponge-derived small molecules (eg, EPI compounds), mahanine, VPC compounds, JN compounds, and bromodomain and extraterminal domain inhibitors. We highlight the significant in vitro and in vivo data found for each compound and the apparent limitations and/or potential for further development of these agents as PCa therapies.
Electrolyte-induced compositional heterogeneity: A novel approach for rate-controlled oral drug delivery (1999)

In this work a new approach for in situ interactions between drug and electrolyte(s) is devised to control the release of highly water soluble drugs from oral hydrophilic monolithic systems. The model drug diltiazem hydrochloride (water solubility in excess of 50% at 25 degrees C), in conjunction with specific electrolytes, was principally employed in the design of swellable tablet formulations comprised of hydrophilic polymers such as hydroxypropylmethlcellulose (HPMC) or poly(ethylene oxide) (PEO). Electrolytes such as sodium bicarbonate or pentasodium tripolyphosphate were used to modulate intragel pH dynamics, swelling kinetics, and gel properties. Through in situ ionic interactions (an intragel matrix system composed of different chemical species that promote competition for water of hydration), a compositionally heterogeneous structure referred to as a "metamorphic scaffold" was established. It is shown that this latter structure results in the inhibition of drug dissolution, induction of a differential swelling rate, and attainment of "matrix stiffening" and axially provides a uniform gel layer. Presence of such phases in matrix structure and its influence on swelling dynamics enabled control of diltiazem hydrochloride release in a zero-order manner in different pH environments over a 24-h period. From kinetic analysis using the power law expressions [M(t)/M(infinity) = k(1)t(n), M(t)/M(infinity) = k(1)t(n) + k(2)t(2)(n)] and Hopfenberg model [M(t)/M(infinity) = 1 - (1 - k(1)t)(n)], it became apparent that the dynamics of matrix relaxation and controlled erosion were major factors involved in the release mechanism, while the composite rate constant k(1) (in Hopfenberg model) decreased by approximately 2-fold in the presence of electrolyte(s). These findings indicated that the dynamics of swelling and gel formation in the presence of ionizable species within hydrophilic matrices provide an attractive alternative for zero-order drug delivery from a simple monolithic system.
Antigenic cross‐reactivity between the human whipworm, <i>Trichuris trichiura</i>, and the mouse trichuroids <i>Trichuris muris</i> and <i>Trichinella spiralis</i> (1988)

Cross-reactivity was demonstrated between circulating antibodies from Trichuris trichiura-infected humans and T. muris-infected mice for heterologous antigen preparations. Mouse immune sera raised against excretory/secretory (E/S) products and anterior end homogenate from adult T. muris showed marked affinity for T. trichiura adult homogenate in ELISA, and 35S-methionine-labelled adult T. muris E/S products were precipitated by T. trichiura infection sera. Monoclonal antibodies recognizing a 48 kD Trichinella spiralis muscle larval beta-stichocyte granule antigen also showed avidity for T. trichiura adult homogenate in ELISA, as did serum from mice with patent T. muris worm burdens. This cross-reactivity is thought to result from shared stichocyte antigens and the relevance of this observation is discussed.
Genome-Wide RNAi Analysis of Growth and Viability in <i>Drosophila</i> Cells (2004)

A crucial aim upon completion of whole genome sequences is the functional analysis of all predicted genes. We have applied a high-throughput RNA-interference (RNAi) screen of 19,470 double-stranded (ds) RNAs in cultured cells to characterize the function of nearly all (91%) predicted Drosophila genes in cell growth and viability. We found 438 dsRNAs that identified essential genes, among which 80% lacked mutant alleles. A quantitative assay of cell number was applied to identify genes of known and uncharacterized functions. In particular, we demonstrate a role for the homolog of a mammalian acute myeloid leukemia gene (AML1) in cell survival. Such a systematic screen for cell phenotypes, such as cell viability, can thus be effective in characterizing functionally related genes on a genome-wide scale.
A novel HV double pulse modulator (1994)

A high-voltage double pulse modulator has been developed which is capable of generating two discrete rectangular pulses with a variable interpulse delay. It is comprised of two Blumlein pulse forming networks connected in series, and discharged independently using high-pressure spark gap switches. Each voltage pulse is 120 ns in duration with a risetime of approximately 15 ns. The maximum output voltage is 350 kV of either polarity, and the output impedance is 200 Omega .
AIDS Virus Genomes (1985)

4 groups of researchers have recently determined the complete nucleotide sequences of the genetic material of viruses that have been linked to acquired immunodeficiency syndrome (AIDS). Although these viruses have been given different names (AIDS-associated retrovirus human T-cell lymphotropic virus type III (HTLV-III) and lymphadenopathy associated virus (LAV) there is general agreement that all are variants of the same virus. These findings should be helpful in answering the question of how closely the AIDS virus resembles other retroviruses especially HTLV-I and II. Another important questions concerns whether the genome of the AIDS virus contains a long-open reading frame (LOR) near its right-hand end similar to those in the HTLV-I and II genomes. The products of the HTLV-I and II LOR regions increase viral and possibly cellular gene expression and this activity may be what causes the malignant transformation of infected cells. Finally restriction mapping of the genomes of various AIDS virus isolates has shown that these may vary in structure. Sequence analysis may help to identify viral gene segments that are highly conserved and thus might be important for viral activities. In addition the corresponding peptides might prove useful for producing reagents to detect infection or a vaccine aganist AIDS.
Digital Photography and 3D MRI–based Multimodal Imaging for Individualized Planning of Resective Neocortical Epilepsy Surgery (2002)

Digital photography in combination with preimplantation 3D MRI allows the generation of reliable tailored resection plans in neocortical epilepsy surgery. The method enhances surgical safety and confidence.
Climate talks: A faint ray of sunshine in Cancún (2011)

When thousands of ministers, scientists and activists descended on the Mexican resort town of Cancún for another gruelling round of talks on climate change in early December, they brought with them limited expectations. The 2009 meeting in Copenhagen had produced little more than acrimonious disputes between developed and developing countries over financing and strategy, and prospects appeared no better in the run-up to Cancún. But in the end participants were surprised to find themselves in agreement on some key points.
Innovative risk management and case study of CNOOC Insurance Limited (2007)

A self-insurance company refers to an insurance or re-insurance company, owned by a non-insurance business entity, primarily designed to insure against the risks faced by that non-insurance business entity or its affiliates. As a non-conventional tool for risk management created in the ongoing wave of risk management innovation by businesses, a self-insurance company connects the parent company directly with the insurance market, and is an efficient tool for global risk management: it reduces the parent company's premium cost, increases the ability to spread risks by establishing a risk reserve fund, increases the parent company's profitability by avoiding the effect of fluctuations in commercial insurance premium, and insures against risks that the parent company cannot get covered in the commercial insurance market. There were as many as 4800 self-insurance companies in the world in 2004. CNOOC Insurance Limited, the only self-insurance company in China, was founded in August, 2000, in Hong Kong. Guided by CNOOC's risk management strategy and in response to market-driven changes in its operating strategy, CIL is rapidly growing.
Regression of cervical intraepithelial neoplasia and loss of human papillomavirus (HPV) infection is associated with cell-mediated immune responses to an HPV type 16 E7 peptide. (2002)

Most human papillomavirus (HPV)-associated cervical intraepithelial neoplasia(CIN) lesions in normal women regress spontaneously, but a small number persist and may progress to invasive cancer. To evaluate the role of immunity to HPV and the outcome of CIN and associated HPV infection, we examined cell-mediated immune (CMI) responses to HPV 16 E6 and E7 peptides. One hundred thirty-six women with biopsy-confirmed CIN I or CIN II were followed for 1 year at 3 month intervals. Study subjects were 58% Hispanic, 36% African American, and 6% of other ethnicity, and were attending a municipal hospital colposcopy clinic. At each visit, cervical cytology and cervicovaginal lavage for HPV detection and typing was done, and blood was obtained for immunological studies. Lymphoproliferative CMI responses to HPV 16 E6 and E7 peptides were tested. An end point biopsy was done after the 1-year follow-up. The association between CMI responses to specific peptides and the outcome of disease was evaluated. CMI responses to E7 peptide (37-54) correlated significantly with regression of disease and with resolution of viral infection within 12 months. The protective effects of CMI to this peptide were not HPV type-specific. CMI responses to several other peptides also showed an association with regression, although not significant at present sample size. E7 peptide 37-54 contains one or more human T-cell epitopes. Identification and mapping of "protective" epitopes in the HPV E6 and E7 proteins could lead to the development of immunological assays to determine the risk of CIN and the development of immunotherapeutic protocols for the management of premalignant and malignant HPV-associated neoplasia and, ultimately, for the prevention of cancer.
A study on data deduplication techniques for optimized storage (2014)

In recent years, the explosion of the data such as text, image, audio, video, data centers and backup data lead to a lot of problem in both storage and retrieval process. The enterprises invest lot of money for storing the data. Hence, an efficient technique is needed for handling the enormous data. There are two existing techniques for eliminating the redundant data in the storage system such as data deduplication and data reduction. Data deduplication is one of the best technique which eliminates redundant data, reduces the bandwidth and also minimizes the disk usage and cost. Various research papers have been studied from the literature, as the result, this paper attempts to summarize various storage optimization techniques, concepts and categories using data deduplication. In addition to this, chunk based data deduplication techniques are surveyed in detail.
Arrayed-waveguide grating with wavefront compensation lenses for spatial filter integration (2006)

We have proposed and fabricated an arrayed-waveguide grating (AWG) with an integrated lens system that is designed to obtain a flat output wavefront. A spatial filter or spatial light modulator could be integrated easily at the output facet of the waveguide. A patterned mirror was attached to the AWG, and doubling of the pulse repetition rate was successfully demonstrated.
Comparison of Chemiluminescence and Ultraviolet Ozone Monitor Responses in the Presence of Humidity and Photochemical Pollutants (1993)

The effect of water vapor and other pollutants on ozone monitoring instruments was investigated. Five UV-type and two chemiluminescence-type monitors were employed in this study. The results of the study indicate that in systems containing ozone, water vapor and zero air only, the UV-based monitors showed negligible effects due to humidity. On average, the UV monitors were within 0.5 percent of independently determined ozone values judged to be extremely accurate. The chemiluminescence-based monitors showed systematically higher readings than the UV monitors with added water vapor. The effect was found to be linear with water vapor concentration with an average positive deviation of 3.0 percent per percent H2O at 25 degrees C. For these measurement, ozone concentrations ranged from 85 to 320 ppbv and water concentrations from 1 to 3 percent (i.e., dew point temperatures from 9 to 24 degrees C). These results are largely in agreement with previous studies conducted to measure this interference, although the present study extends the range of water concentrations tested. Studies were also performed with a smog chamber with simulated polluted air (containing paraffinic, olefinic and aromatic hydrocarbon precursors) and varying relative humidities. Although the presence of water vapor did not appear to represent a substantial interference in these systems, a positive interference was observed with the UV monitors. This interference was likely a result of the presence of toluene and some of its aromatic photooxidation products (e.g., benzaldehyde), which can be partially removed from the reference stream by the ozone scrubber within the UV monitor. If the compound absorbs radiation at 254 nm, it is detected as ozone. However, when the results are scaled back to ambient concentrations of toluene and NO(x), the effect appears to be very minor (ca. 3 percent under the study conditions). It is concluded that under atmospheric conditions at moderate pollution and relative humidity levels, both types of instruments can give accurate measurements of the ozone concentration. These potential effects should be recognized when conducting ambient ozone measurements.
Design, modeling, and fabrication of mm<sup>3</sup> three-dimensional integrated antennas (2012)

This paper describes the design, modeling, and fabrication methods of a new method to build three-dimensional integrated antenna arrays. The goal is to create a mm-scale sensor for implantation in the human body. Since the orientation of the sensor is not known in advance the antenna must work equally well in all directions. The best way to do this is to build antennas on each side of a cubic structure. The antenna is intended for near field power harvesting. By utilizing the edge antenna the power transfer efficiency can be increased by 18.9 dB at even the worst orientations for the sensors. Another application would be to create an omnidirectional antenna for high frequency mobile devices.
Node Positioning in ZigBee Network Using Trilateration Method Based on the Received Signal Strength Indicator (RSSI) (2010)

This paper investigates the possibility of implementing node positioning in the ZigBee wireless sensor network by using a readily available Received Signal Strength Indicator (RSSI) infrastructure provided by the physical layer of 802.15.4 networks. In this study the RSSI is converted to the distance providing the basis for using the trilateration methods for location estimation. The software written in C# is used to solve the trilateration problem and the final results of trilateration methods are mapped using Google maps. Providing node positioning capability to the ZigBee network offers an enormous benefit to the Wireless Sensor Networks applications, possibly extending the functionality of existing software solution to include node tracking and monitoring without an additional hardware investment.