gebhart/patrepeval huggingface dataset:
Mirror-Image and Invariant Distributions in ARMA Models (1989)

The finite sample distributions of estimators and test statistics in ARMA time series models are generally unknown. For typical sample sizes, the approximations provided by asymptotic distributions are often unsatisfactory. Hence simulation or numerical integration methods are used to investigate the distributions. In practice only a limited part of the parameter space is examined using these methods. Thus any results which allow us to infer properties from one portion of the parameter space to another or to establish symmetry are most welcome. For the ARMA model estimated with no intercept term, we show that the least-squares and maximum likelihood estimators have mirror-image invariant or symmetric distributions. The F, t , likelihood ratio, Wald, and Lagrange multiplier statistics are also shown to have distributions with certain mirror-image invariant or symmetry properties. The analysis is extended to misspecified models as well as to ARMA spectral densities. These properties would have been helpful in either simplifying or extending much earlier work in this area.
Real-time video mosaicking of the ocean floor (1995)

An approach was developed for real-time creation of video mosaics of the ocean floor. The approach uses visual correspondence during both image acquisition and consolidation to insure that there are no gaps in the mosaic. The use of visual information for mosaic creation offers an accuracy previously unachievable in real time. A complete mosaicking approach was developed, including a technique for image registration and several strategies for image acquisition control. The approach was implemented and tested experimentally. Ocean-floor mosaics were created in real time using a remotely-operated vehicle. In addition, extensive mosaicking experiments were conducted in a test-tank environment using a semiautonomous underwater robot.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Bioequivalence of a Darunavir/Cobicistat Fixed-Dose Combination Tablet versus Single Agents and Food Effect in Healthy Volunteers (2013)

Bioequivalence of the darunavir/cobicistat 800/150-mg FDC was demonstrated versus darunavir and cobicistat co-administered as single agents under fasted or fed conditions. Food increased darunavir exposure, therefore, darunavir/cobicistat should be administered with food.
Molecular Dynamics Study of a Carbon Nanotube Binding Reversible Cyclic Peptide (2010)

Many potential biological applications of single-walled carbon nanotubes (SWNTs) require their dispersion in aqueous conditions. Recently, Dieckmann et al. designed a series of reversible cyclic peptides (RCPs) which exist in linear or cyclized states through controlled formation of an intramolecular disulfide bond between terminal Cys residues. These RCP-Cys peptides have been shown to disperse SWNTs in aqueous solution and form peptide/SWNT complexes which are stable against dilution. However, the detailed molecular interactions between the peptide and the SWNT in an aqueous environment remain unexplored. Here, fully atomistic molecular dynamics simulations were used to study the effect of RCP-Cys at the water/SWNT interface. We show that the peptide-SWNT association is thermodynamically favorable through free energy calculations. Furthermore, we analyze the structure and energetics of the possible beta-sheet-like ring stacking that can form on the SWNT through peptide backbone hydrogen bonding. Our results reveal the thermodynamic driving force for the formation of an ordered, self-assembled RCP-Cys/SWNT complex, which provides insight into peptide design strategies for future applications.
<title>Surface mechanics of biological tissues using low-frequency rayleigh waves detected by laser speckle</title> (2002)

An acousto-optical method for the determination of the mechanical loss factor in biological tissues is presented. Measurements of the loss factor were made on a polyvinyl chloride (PVC) phantom, elastin derived from a bovine nuchal ligament, and porcine skin. The acousto-optical values of the loss factor were compared with those measured with a more conventional mechanical testing system. The values for the mechanical loss factor for PVC and nuchal elastin as calculated from the acousto-optical method agreed with those determined using the mechanical testing system. However, there was a significant difference between the two methods for the porcine skin. We hypothesize that the acousto- optical method measures only the stratum corneum of the skin while the mechanical method evaluates the bulk properties of the skin. The rigid, keratinous fibers of the stratum corneum are believed to be responsible for the lower loss factor measured with the acousto-optical method.
<title>Adaptive nonlinear neural network controller for rotorcraft vibration</title> (1997)

This paper presents research into developing an adaptive nonlinear neural network control algorithm that can be used with smart structure actuators and sensors to control the vibrations of rotor blades. The dynamic equations of motion for a blade have the same form as a multilink manipulator (robot arm) and adaptive nonlinear control algorithms have proven successful in active control of these manipulators. The recent development of neural network control algorithms has provided the ability to adaptively learn in real time a set of parameters that will approximate external forces operating on the blades. The controller combines these two control techniques enabling the controller to adapt its parameters in response to changes in blade properties such as its mass or stiffness and to also learn the parameters necessary to account for the unknown but bounded, periodic disturbance forces such as those caused by the unsteady, periodic aerodynamic forces in the rotor system. Current efforts have been directed at testing the control algorithm on real beams with piezoceramic actuators and sensors. The initial test results have shown that vibration reduction and desired beam motion tracking can be achieved even under the influences of periodic disturbances.
Study to Compare Capsule and Liquid Formulations of Enzalutamide After <scp>Single-Dose</scp> Administration Under Fasting Conditions in Prostate Cancer (2021)

Preliminary evidence suggests a similar pharmacokinetic profile when administering liquid extracted from enzalutamide soft-gelatin capsules compared with intact capsules in patients with prostate cancer.
Designing smartcards for collaboration with the WiMAX security sublayer (2007)

In this paper we introduce smartcards dedicated to emerging WiMAX networks. In such architectures, security services are ensured by a logical entity called the ldquoprivacy sublayerrdquo. We attempt to define collaborative procedures performed by tamper resistant devices, in order to reduce hacking threats and to enhance the trust, both for subscribers and operators.
Persistent B <sup>+</sup> -trees in non-volatile main memory (2015)

Computer systems in the near future are expected to have <u>N</u>on-<u>V</u>olatile <u>M</u>ain <u>M</u>emory (NVMM), enabled by a new generation of <u>N</u>on-<u>V</u>olatile <u>M</u>emory (NVM) technologies, such as Phase Change Memory (PCM), STT-MRAM, and Memristor. The non-volatility property has the promise to persist in-memory data structures for instantaneous failure recovery. However, realizing such promise requires a careful design to ensure that in-memory data structures are in known consistent states after failures. This paper studies persistent in-memory B + -Trees as B + -Trees are widely used in database and data-intensive systems. While traditional techniques, such as undo-redo logging and shadowing, support persistent B + -Trees, we find that they incur drastic performance overhead because of extensive NVM writes and CPU cache flush operations. PCM-friendly B + -Trees with unsorted leaf nodes help mediate this issue, but the remaining overhead is still large. In this paper, we propose write atomic B + -Trees (wB + -Trees), a new type of main-memory B + -Trees, that aim to reduce such overhead as much as possible. wB + -Tree nodes employ a small indirect slot array and/or a bitmap so that most insertions and deletions do not require the movement of index entries. In this way, wB + -Trees can achieve node consistency either through atomic writes in the nodes or by redo-only logging. We model fast NVM using DRAM on a real machine and model PCM using a cycle-accurate simulator. Experimental results show that compared with previous persistent B + -Tree solutions, wB + -Trees achieve up to 8.8x speedups on DRAM-like fast NVM and up to 27.1x speedups on PCM for insertions and deletions while maintaining good search performance. Moreover, we replaced Memcached's internal hash index with tree indices. Our real machine Memcached experiments show that wB + -Trees achieve up to 3.8X improvements over previous persistent tree structures with undo-redo logging or shadowing.
Compact Sunshade For Telescope Antenna (1990)

Proposed built-in sunshade enables large-aperture reflecting telescope to view laser transmitter apparently close to Sun, without adding excessive size or mass to telescope. Telescope looks through sunshade from behind and below. Tops of hexagonal tubes trimmed to spherical shape corresponding to sphere of rotation of telescope. Sunshade supports secondary reflector. Discerns signals from sources only 12 degrees from line of sight to Sun. Sunshade equipped with internal vanes running lengths of tubes receives signals from sources within 6 degree or even 3 degree of apparent position of Sun.
Purine Sulfonamides (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPurine SulfonamidesAlden G. Beaman, William Tautz, Robert Duschinsky, and E. GrunbergCite this: J. Med. Chem. 1966, 9, 3, 373–378Publication Date (Print):May 1, 1966Publication History Published online1 May 2002Published inissue 1 May 1966https://pubs.acs.org/doi/10.1021/jm00321a027https://doi.org/10.1021/jm00321a027research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expression and secretion of recombinant ovine <i>β</i>-lactoglobulin in <i>Saccharomyces cerevisiae</i> and <i>Kluyveromyces lactis</i> (1996)

High expression and secretion of recombinant ovine beta-lactoglobulin has been achieved in the yeast Kluyveromyces lactis. The yield of beta-lactoglobulin is 40-50 mg per litre of culture supernatant and accounts for approx. 72% of the total secreted protein. Constitutive expression is under the control of the Saccharomyces cerevisiae phosphoglycerate kinase promoter from an intronless version of the beta-lactoglobulin gene. Secretion is specified by the ovine protein's own signal sequence. this system, coupled to an efficient and novel recovery protocol, allows 30 mg of pure protein to be isolated from a typical 1 litre culture. The protein is virtually indistinguishable from beta-lactoglobulin conventionally purified from sheep milk by its behaviour in native PAGE and SDS/PAGE, reactivity to antibodies, CD, fluorescence spectroscopy and N-terminal sequencing. Attempts to achieve a similar expression and secretion system in the yeast S. cerevisiae met with only limited success, although it was found that heat-shock treatment modestly increased the yield up to approx. 3-4 mg per litre of culture supernatant. Site-directed mutagenesis showed that secretion in S. cerevisiae depended upon correct formation of the two disulphide bonds present in beta-lactoglobulin.
6T SRAM and 3T DRAM data retention and remanence characterization in 65nm bulk CMOS (2012)

While SRAM and DRAM are often assumed to have very small data retention times (bits are lost immediately at power-down) and no data remanence (stored bits leave no traces even after a prolonged storage period), under some conditions these assumptions do not hold. Both retention and remanence have been exploited by malicious attackers to compromise system data and encryption keys in secure systems. To precisely measure retention and remanence in SRAM and DRAM, we implemented specially instrumented 6T SRAM and 3T DRAM test structures in 65nm bulk CMOS and tested them from -40°C to 85°C and under accelerated aging conditions. Results show that the 50% retention time (i.e., half the bits retained data) is 44 ms for the 6T SRAM and 3.8 ms for the 3T DRAM at -40°C. Further, the data remanence effects were exploited to predict stored bits with over 82% accuracy for 22% of a 4kb SRAM array.
Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis (2001)

We have cloned and expressed the inducible form of prostaglandin (PG) E synthase from rat and characterized its regulation of expression in several tissues after in vivo lipopoylsaccharide (LPS) challenge. The rat PGE synthase is 80% identical to the human enzyme at the amino acid level and catalyzes the conversion of PGH(2) to PGE(2) when overexpressed in Chinese hamster ovary K1 (CHO-K1) cells. PGE synthase activity was measured using [(3)H]PGH(2) as substrate and stannous chloride to terminate the reaction and convert all unreacted unstable PGH(2) to PGF(2alpha) before high pressure liquid chromatography analysis. We assessed the induction of PGE synthase in tissues from Harlan Sprague-Dawley rats after LPS-induced pyresis in vivo. Rat PGE synthase was up-regulated at the mRNA level in lung, colon, brain, heart, testis, spleen, and seminal vesicles. Cyclooxygenase (COX)-2 and interleukin 1beta were also up-regulated in these tissues, although to different extents than PGE synthase. PGE synthase and COX-2 were also up-regulated to the greatest extent in a rat model of adjuvant-induced arthritis. The RNA induction of PGE synthase in lung and the adjuvant-treated paw correlated with a 3.8- and 16-fold induction of protein seen in these tissues by immunoblot analysis. Because PGE synthase is a member of the membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) family, of which leukotriene (LT) C(4) synthase and 5-lipoxygenase-activating protein are also members, we tested the effect of LTC(4) and the 5-lipoxygenase-activating protein inhibitor MK-886 on PGE synthase activity. LTC(4) and MK-886 were found to inhibit the activity with IC(50) values of 1.2 and 3.2 microm, respectively. The results demonstrate that PGE synthase is up-regulated in vivo after LPS or adjuvant administration and suggest that this is a key enzyme involved in the formation of PGE(2) in COX-2-mediated inflammatory and pyretic responses.
The binding of alpha-1 antitrypsin to human IgA. (1974)

Complex formation between IgA and several serum proteins including albumin (1), βlipoproteins (2), haptoglobins (3), anti-hemophilic globulin (4) and in one case, to α1 glycoprotein (3) has been previously noted. However, with the exception of albumin, the binding of these proteins to IgA myeloma proteins has not been regularly observed. It has been reported (3) that 53% of IgA myeloma proteins as well as 74% of monoclonal IgM proteins complex with albumin. Subsequently, a thorough study by Mannik (5) demonstrated that the binding of albumin by both IgA and IgM proteins involved covalent disulfide bonds. Presumably, the binding site is located in the heavy chain and could involve the free SH group thought to be present in the α-chain (6), although this has not been directly demonstrated. During the course of a study attempting to localize the site of albumin binding to IgA proteins, an antiserum to albumin was employed which also contained antibodies to α1 antitrypsin (α1AT). 2
Remote RF powering system for wireless MEMS strain sensors (2006)

A reliable remote radio frequency (RF) powering system is developed for industrial wireless microelectromechanical systems (MEMS) strain-sensing applications. The prototype system is insensitive to mechanical rotation and produces a stable DC voltage of 2.8 V with a 2-mA current supply capability from a 50-MHz RF power source with a power conversion efficiency of 11%. An improved efficiency can be expected with an optimized power transmitter design. The CMOS power converter electronics are fabricated in a 1.5-/spl mu/m CMOS process occupying an area of approximately 1 /spl times/1 mm. The achieved DC power is adequate for supplying a high-performance wireless MEMS strain-sensing system.
Safety benefits of PathProx-a runway incursion alerting system (2003)

This paper analyzes the safety benefits of the implementation of PathProx, a runway incursion alerting system. Airport surface incursions have been identified by the National Transportation Safety Board (NTSB) as one of the most significant safety hazards in civil aviation. PathProx is a system development by Rannoch Corporation to help address this problem. It is an aircraft-based runway incursion alerting system, providing runway incursion alerts directly to the pilot(s) in the cockpit. PathProx has undergone a series of simulator and flight tests conducted by NASA over the last 3 years. It is part of the NASA Runway Incursion Prevention System (RIPS). These tests have validated the basic concept and design of PathProx. Several analyses have been performed related to the safety benefits of PathProx implementation. These include analysed of critical runway incursion scenarios and Monte Carlo simulation. The Monte Carlo simulation results indicated that the risk of collisions due to runway incursions could be nearly eliminated through aircraft equipage with PathProx. The simulations and analyses also found that PathProx provides significant improvement in runway safety even without full fleet equipage-where only of the two aircraft involved in a conflict is equipped. Analyses have also been done to compare the safety improvements provided by PathProx with that provided by ground system surveillance and alerting. PathProx provides more timely alerting than provided by ground-based systems, primarily by eliminating the delays associated with having the controller in the loop and associated communications delay.
UniGlyph (2007)

Previously, we developed a text input method called Glyph which we improved later to make it possible to enter text on mobile devices with two keystrokes per character, then with one simple gesture per character using seven keys. In this paper, we announce a new method called "UniGlyph". It allows typing text with one keystroke per character using only four keys. We present also a novice level evaluation of UniGlyph compared to two similar methods.
Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine. (1988)

Human apolipoprotein B (apoB) is present in plasma as two separate isoproteins, designated apoB-100 (512 kDa) and apoB-48 (250 kDa). ApoB is encoded by a single gene on chromosome 2, and a single nuclear mRNA is edited and processed into two separate apoB mRNAs. A 14.1-kilobase apoB mRNA codes for apoB-100, and the second mRNA, which codes for apoB-48, contains a premature stop codon generated by a single base substitution of cytosine to uracil at nucleotide 6538, which converts the translated CAA codon coding for the amino acid glutamine at residue 2153 in apoB-100 to a premature in-frame stop codon (UAA). Two 30-base synthetic oligonucleotides (nucleotides 6523-6552 of apoB mRNA), designated apoB-Stop and apoB-Gln, were synthesized containing the complementary sequence to the stop codon (UAA) and glutamine codon (CAA), respectively. Analysis of intestinal apoB mRNA by hybridization with apoB-Stop and apoB-Gln probes and sequence analysis of apoB clones in two independent human small intestinal cDNA libraries established that intestinal apoB mRNA contained both the apoB mRNA that codes for apoB-100 and the apoB mRNA containing the premature in-frame stop codon, which codes for apoB-48. Investigation of hepatic apoB mRNA and two hepatic cDNA libraries by hybridization with the apoB-Stop and apoB-Gln synthetic probes as well as by cDNA sequencing revealed that liver apoB mRNA also contains both the apoB-100 mRNA and the apoB-48 mRNA containing the stop codon. The combined results from these studies establish that both human intestine and liver contain the two distinct apoB mRNAs, an mRNA that codes for apoB-100 and an apoB mRNA that contains the premature stop codon, which codes for apoB-48. The premature in-frame stop codon is not tissue specific and is present in both human liver and intestine.
Assumptions of the API Rod Pumping Design Method as Related to Practical Applications and Wave Equation Techniques (1994)

Abstract The American Petroleum Institute (API) method for rod pumping system design became available in the mid 1960's. Even after 30 years, questions still arise concerning its utility. This paper examines basic premises of the API method and how these affect accuracy and applicability. A comparison is made with wave equation techniques which are also widely used. It is concluded that the API method is useful and can be applied with confidence as long as underlying assumptions are not violated.