gebhart/patrepeval huggingface dataset:
Chemical and Enzymatic Synthesis of 1-Deoxy-<scp>d</scp>-xylulose-5-phosphate (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTChemical and Enzymatic Synthesis of 1-Deoxy-d-xylulose-5-phosphateSean V. Taylor, Long D. Vu, Tadhg P. Begley, Ulrich Schörken, Sigrid Grolle, Georg A. Sprenger, Stephanie Bringer-Meyer, and Hermann SahmView Author Information Department of Chemistry, Cornell University, Baker Laboratory, Ithaca, New York 14853 Institut für Biotechnologie, 1 des Forschungszentrums Jülich GmbH, Postfach 1913, D-52425 Jülich, Germany Cite this: J. Org. Chem. 1998, 63, 7, 2375–2377Publication Date (Web):March 18, 1998Publication History Received20 October 1997Published online18 March 1998Published inissue 1 April 1998https://pubs.acs.org/doi/10.1021/jo971933phttps://doi.org/10.1021/jo971933pbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views642Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Bacteria,Biosynthesis,Chemical synthesis,Peptides and proteins,Precursors Get e-Alerts
Calix[<i>n</i>]arene‐Based Glycoclusters: Bioactivity of Thiourea‐Linked Galactose/Lactose Moieties as Inhibitors of Binding of Medically Relevant Lectins to a Glycoprotein and Cell‐Surface Glycoconjugates and Selectivity among Human Adhesion/Growth‐Regulatory Galectins (2008)

Growing insights into the functionality of lectin-carbohydrate interactions are identifying attractive new targets for drug design. As glycan recognition is regulated by the structure of the sugar epitope and also by topological aspects of its presentation, a suitable arrangement of ligands in synthetic glycoclusters has the potential to enhance their avidity and selectivity. If adequately realized, such compounds might find medical applications. This is why we focused on lectins of clinical interest, acting either as a potent biohazard (a toxin from Viscum album L. akin to ricin) or as a factor in tumor progression (human galectins-1, -3, and -4). Using a set of 14 calix[n]arenes (n=4, 6, and 8) with thiourea-linked galactose or lactose moieties, we first ascertained the lectin-binding properties of the derivatized sugar head groups conjugated to the synthetic macrocycles. Despite their high degree of flexibility, the calix[6,8]arenes proved especially effective for the plant AB-toxin, in the solid-phase model system with a single glycoprotein (asialofetuin) and with human tumor cells in vitro. The bioactivity of the calix[n]arenes was also proven for human galectins. Notably, selectivity for the tested tandem-repeat-type galectin-4 among the three subgroups was determined at the level of solid-phase and cell assays, the large flexible macrocycles again figuring prominently as inhibitors. Alternate and cone versions of calix[4]arene with lactose units distinguished between galectins-1 and -4 versus galectin-3 in cell assays. The results thus revealed bioactivity of galactose-/lactose-presenting calix[n]arenes for medically relevant lectins and selectivity within the family of adhesion/growth-regulatory human galectins.
Morpheus: Learning configurations by example (2013)

Cloud computing presents a model to automatically deploy workloads using standard templates. However, reconfiguring the application to work in the new environment is manual and time-consuming. In this work, we present Morpheus to automatically configure new instances of a workload by leveraging a pre-configured instance. Morpheus uses a configured instance of a workload, annotated with the configuration information, and automatically configures new instances of the workload. It is important to note that it can configure application instances that may be installed differently or may be running a different version of the application, middleware or operating system. Morpheus first maps configuration files from the template instance to configuration files in each new instance. In the second phase, configuration nodes in source file are mapped to the target file and configuration information is automatically added in the target instance. The mapping is performed using text and structure analysis in the configuration files. We used Morpheus to automatically deploy new workloads for a wide variety of multi-tier enterprise/web applications. It was able to deploy them without any manual intervention in 13-68 minutes for 100% of the workloads.
Sensor fusion for a biometric system using gait (2002)

We consider a multimodal biometric system which authenticates people based on their gait. Computationally efficient techniques were developed to extract characteristic gait features from ground reaction force and video data of the walking subject. Specifically, the data consists of one classifier based on the ground reaction force and three based on visual features. A new variant of the generalized principal component analysis is used to efficiently reduce data dimensionality and to optimize class separability. A technique based on the Bayes risk criterion subsequently integrates the multiple classifiers. The proposed multimodal approach significantly increases recognition robustness and reliability. Experimental results showed an equal error rate of less than 0.3% which makes the method applicable for medium security applications.
연구논문 : 인적자원의 효율적 축적과 활용을 위한 제언 (1998)

In this paper, we examine the existing economics and management literature that looked at the relationship between human resource (HR) management practices and firm performance, and economic growth. Based on the literature review, we suggest effective HR strategies for the government and the firms. As HR policy for the government, we suggest nurturing of training and education industry, introducing HR development fund, voucher systems, HR accounting, and learning contract, adjusting public and private certification systems, and forming cooperative industry complexes. As HR strategy for the firms, we suggest combining individual pay-for-skill and group incentive systems, selective operation of multiskill formation, HR oriented labor-management relation, increasing empowerment at the workplace, improving roles and career management of supervisors, designing the optimum size of workshop, and formulating strategic HR planning based on long-term perspective.
Susceptibility of DA Rats to Arthritis Induced With Adjuvant Oil or Rat Collagen is Determined by Genes Both Within and Outside the Major Histocompatibility Complex (1996)

Inbred DA rats are remarkably susceptible to arthritis induced both by non-immunogenic mineral oil only (OIA) and by rat collagen II together with mineral oil (rCIA). This fact enables interesting studies concerning which DA genes are associated with the arthritogenicity of adjuvant oil and collagen, respectively. In this paper the authors have investigated the role of genes within and outside the major histocompatibility complex (MHC), in this respect by comparative susceptibility studies in inbred rat strains (DA, LEW) and MHC-congenic strains (DA.1I, DA.1O, DA.1M, DA.1H, LEW.1AV1, PVG.1AV1). The authors confirm earlier reports on the arthritis-promoting nature of the DA MHC haplotype (RT1av1), but demonstrate that neither OIA nor rCIA is restricted to this haplotype or its class II alleles (Ba, Da). A decisive role of non-MHC genes in determining susceptibility is also clear since the PVG.1AV1 strain, with the permissive RT1av1 haplotype, is resistant to both arthritis models. In conclusion, the authors demonstrate that the susceptibility of DA rats to OIA and rCIA is determined similarly, by permissive genes both within and outside the MHC. Second, and more interesting from a general perspective, the investigation demonstrates a notable influence of genes within and outside the MHC on the pathogenic capacity of a non-immunogenic adjuvant oil. This adjuvant is in turn a critical component in provocations leading not only to rCIA but also to many other experimental autoimmune diseases where the influence of 'adjuvant response genes' is rarely considered.
3D inversion of surface to borehole CSEM for waterflood monitoring (2018)

A surface-to-borehole controlled source electromagnetic (CSEM) survey was acquired in a research well in the eastern province of Saudi Arabia to monitor waterfront movement in a supergiant oil field. The initial baseline CSEM survey was conducted in a vertical observation well in the spring of 2017. The recorded data show excellent spatial correlation with resistivity variations predicted by reservoir simulation. A finite difference model of the overburden and wellbore casing is used to invert for resistivity estimates of the reservoir surrounding the well. The inversion results suggest the CSEM data robustly recovers resistivity patterns up to approximately 1.8 km away from the well and agree with the oil distribution derived from well observations. Presentation Date: Tuesday, October 16, 2018 Start Time: 1:50:00 PM Location: 213A (Anaheim Convention Center) Presentation Type: Oral
Polymer Waveguide Label-Free Biosensors With Enhanced Sensitivity by Incorporating Low-Refractive-Index Polymers (2009)

Label-free biosensors consisting of polymeric waveguides with a Bragg reflection grating are demonstrated for the purpose of highly sensitive protein detectors. Due to the unique nanoimprinting and injection molding processes, polymer waveguide devices have the potential to provide cost-effective disposable biosensors as long as a robust compatible immunoassay process is developed. A fluorinated polymer material with the lowest refractive index, which is close to that of the saline solution, is used for the sensor waveguide, in order to increase the effective index modulation efficiency. The large contrast waveguide exhibits a 1.9 times higher sensitivity for the detection of the variation of the cover index compared to low-contrast sensors. Bragg reflectors with a 3-dB bandwidth of 0.9 nm are fabricated using laser interferometry and dry etching of the core layer by 50 nm. An immunoassay experiment to detect the concentration of antibiotin is performed by measuring the peak wavelength shift of the Bragg reflection sensors. By using a blocking buffer, it is possible to obtain a stable saturated output signal by preventing the nonspecific binding. In the experiment to measure the antibiotin concentration, the sensor exhibits linear correspondence of peak wavelength shift for the concentrations.
Vip Increases in Nasal Blood During Stimulation of the Vidian Nerve (1981)

In chronically sympathectomized cats Vidian nerve stimulation evoked vasodilatation concomitant with an increase of VIP concentration in venous plasma effluent from the nasal mucosa. the VIP increase and the vasodilatation was not affected by atropine administration, but abolished by hexamethonium. It is suggested that neuronal VIP may be the mediator of the atropine-resistant vasodilatation.
Tocolysis of Preterm Contractions does not Improve Preterm Delivery Rate or Perinatal Outcomes (1998)

To determine whether hospital admission and parenteral tocolysis of patients with threatened preterm labor results in a decreased preterm delivery rate and improved perinatal outcome, we performed a prospective cohort study comparing tocolytic treatment versus no tocolytic treatment. Women between 20 and 37 weeks' gestation who presented with at least eight uterine contractions per hour and a cervical examination <2 cm dilated, <80% effaced, and no cervical change over a 2-hr period were entered into the study. Exclusion criteria included cervical change, multiple gestation, chorioamnionitis, rupture of membranes, placenta previa or abruption, undiagnosed vaginal bleeding, and prior tocolytic therapy in the current pregnancy. Seventy-five patients were admitted to the hospital for tocolysis (tocolysis cohort) and 81 were observed and discharged to home (observation cohort). There was no significant difference in mean gestational age at delivery, mean birth weight, or in preterm delivery rate between the two cohorts. Four of the eight women in the observation cohort who delivered preterm had a history of preterm delivery. We conclude that discharging women with preterm contractions without objective evidence of labor does not result in an increase in preterm births. More importantly, tocolysis did not decrease the preterm delivery rate in this cohort.
Assessment and optimization of an airplane (2014)

Purpose The ratio of the energy transformed to the revenue work done (ETRW) during a flight of an airplane can be employed as a key indicator to assess its environmental impact. It remains constant during the life cycle of the aircraft and is fixed by its designers. The goal of an environmentally optimum airplane is to minimize the ETRW.
Importance and significance of raw milk quality to the liquid milk processor (1984)

The importance and significance of raw milk quality to the liquid milk processor are considered in the light of changing commercial pressures. The attributes the processor seeks in his raw milk supplies are examined, how he handles and processes this milk to ensure customer satisfaction and, finally, what improvements still need to be made in the quality field.
EXCRETION AND METABOLISM OF [<sup>14</sup>C]‐PYRIDOSTIGMINE IN THE RAT (1966)

Although pyridostigmine is extensively used in the treatment of myasthenia gravis, there is little information available about its absorption, excretion and distribution. Nowell, Scott & Wilson (1962) showed that after oral administration to patients with myasthenia gravis a greater proportion of the daily dose of pyridostigmine was excreted in the urine than of neostigmine. They also reported that after withdrawing treatment the excretion of pyridostigmine in the urine continued for at least 2 days, whereas when treatment with neostigmine was stopped this drug was not detected in the urine after 24 hr. They suggested that pyridostigmine and neostigmine might differ also in their rates of metabolism but they were unable to provide evidence in support of this because the metabolites of these drugs could not be estimated by their assay procedure.
Activation of the CPP32 Apoptotic Protease by Distinct Signaling Pathways with Differential Sensitivity to Bcl-xL (1996)

In the absence of growth factors, many types of mammalian cells undergo apoptosis. We and others have shown recently that growth factors promote cell survival by activating phosphatidylinositol 3-kinase (PI 3-kinase) in several cell types. In the present study, we have compared downstream elements of the apoptotic pathways induced by PI 3-kinase inhibitors and other stimuli. In U937 cells, both PI 3-kinase inhibitors (wortmannin and LY294002) and etoposide activated the CPP32 apoptotic protease by cleavage to active p17 subunits. In contrast, treatment with tumor necrosis factor α (TNFα) resulted in the accumulation of a distinct active CPP32 subunit, p20. Furthermore, overexpression of Bcl-xL blocked DNA fragmentation, CPP32 activation and cleavage of poly(ADP-ribose) polymerase in U937 cells treated with both PI 3-kinase inhibitors and etoposide, but not in cells treated with TNFα. Distinct patterns of CPP32 activation and differential sensitivities to Bcl-xL thus distinguish the cell death pathways activated by PI 3-kinase inhibition and DNA damage from that activated by TNFα. In the absence of growth factors, many types of mammalian cells undergo apoptosis. We and others have shown recently that growth factors promote cell survival by activating phosphatidylinositol 3-kinase (PI 3-kinase) in several cell types. In the present study, we have compared downstream elements of the apoptotic pathways induced by PI 3-kinase inhibitors and other stimuli. In U937 cells, both PI 3-kinase inhibitors (wortmannin and LY294002) and etoposide activated the CPP32 apoptotic protease by cleavage to active p17 subunits. In contrast, treatment with tumor necrosis factor α (TNFα) resulted in the accumulation of a distinct active CPP32 subunit, p20. Furthermore, overexpression of Bcl-xL blocked DNA fragmentation, CPP32 activation and cleavage of poly(ADP-ribose) polymerase in U937 cells treated with both PI 3-kinase inhibitors and etoposide, but not in cells treated with TNFα. Distinct patterns of CPP32 activation and differential sensitivities to Bcl-xL thus distinguish the cell death pathways activated by PI 3-kinase inhibition and DNA damage from that activated by TNFα.
刘小平：生命的“根缘” (2010)

去刘小平大师的工作室是要一些勇气的，不是因为工作室在山顶上会让人感到不安，而是那条上山的路，如果没有很好的驾驶技术，劝你还是步行上山。我们一行人到达山顶的时候，一颗“悬着”的心是放了下来，这么“冒险”的去采访一位大师还是头一次。
Software Platforms for Smart Cities: Concepts, Requirements, Challenges, and a Unified Reference Architecture (2016)

Making cities smarter help improve city services and increase citizens' quality of life. Information and communication technologies (ICT) are fundamental for progressing towards smarter city environments. Smart City software platforms potentially support the development and integration of Smart City applications. However, the ICT community must overcome current significant technological and scientific challenges before these platforms can be widely used. This paper surveys the state-of-the-art in software platforms for Smart Cities. We analyzed 23 projects with respect to the most used enabling technologies, as well as functional and non-functional requirements, classifying them into four categories: Cyber-Physical Systems, Internet of Things, Big Data, and Cloud Computing. Based on these results, we derived a reference architecture to guide the development of next-generation software platforms for Smart Cities. Finally, we enumerated the most frequently cited open research challenges, and discussed future opportunities. This survey gives important references for helping application developers, city managers, system operators, end-users, and Smart City researchers to make project, investment, and research decisions.
A general firewire data acquisition platform applied to SPECT (2003)

A sub-system that provides the low-level interface to the IEEE 1394 serial bus (Firewire) has been developed. It is intended to be used as a component providing communication and distributed computing in a data acquisition or control system. IEEE 1394 has a flexible topology and provides large bandwidth capabilities to a system. The platform developed consists of a custom made DSP board executing software that manages the bus protocol and provides an environment for executing data processing or control algorithms. Software running in a PC that encapsulates the low-level API to a Firewire/PCI bridge card is also part of the platform.
Acute effects of calcitonin gene related peptide on renal haemodynamics and renin and angiotensin II secretion in patients with renal disease. (1995)

The renal haemodynamic effects and renin-angiotensin II response to calcitonin gene-related peptide (CGRP) infusion were assessed in 16 patients with moderate hypertension and renal insufficiency. CGRP lowered the systemic mean blood pressure by 13% and increased the heart rate by 25%; the glomerular filtration rate rose from 56 +/- 11 ml/min to 71 +/- 8 ml/min (p < 0.005), the renal plasma flow decreased from 369 +/- 19 ml/min to 342 +/- 25 ml/min (p < 0.002) and the filtration fraction increased from 15 +/- 0.2% to 20 +/- 0.2%. Plasma renin activity rose stepwise during the CGRP infusion from 1.28 +/- 0.5 ng/ml/h to 1.66 +/- 0.4 and 1.89 +/- 0.4 ng/ml/h (p < 0.001). Angiotensin II showed a marked increase after 10 min of infusion (91.6 +/- 47.00 pg/ml) (control value 6.01 +/- 3.09 pg/ml) and at the end (28.63 +/- 16.00 pg/ml) (p < 0.001). CGRP exerts an apparently favourable effect on renal function of patients with renal insufficiency, but the observed increase of glomerular filtration rate is obtained by an increase of intraglomerular pressure secondary to angiotensin II production.
Enhanced current density <i>J</i> <i>c</i> and extended irreversibility in single-crystal Bi2Sr2Ca1Cu2O8 via linear defects from heavy ion irradiation (1992)

Large enhancements in the critical current density Jc were produced in single crystals of the high-temperature superconductor Bi2Sr2Ca1Cu2O8 by irradiation with high energy Sn ions. In addition, the irreversibility line was moved to considerably higher magnetic fields. In contrast with analogous studies on Y1Ba2Cu3O7, there was little, if any, selective pinning when the magnetizing field was applied parallel to the linear, ion-damage-produced tracks.
Temperature Profile Estimation with Smart Textiles (2005)

Current trends in e-textiles and smart fabrics try to find a symbiosis of electronics and clothing. Aug-menting a fabric with an intrinsic sensing function is an elegant way to measure the environment. This approach supports the idea of a smooth combination of the two worlds of electronics and clothing. Our hybrid fabric senses temperature and estimates the temperature profile along the surface. We explain the measurement principle and show how a measurement accuracy of 0.5K with a 10cm long piece of fabric can be achieved. We also point out potential applications of our fabric temperature sensor. 1
Nondynamic Tracking Using The Global Positioning System (1988)

Report describes technique for using Global Positioning System (GPS) to determine position of low Earth orbiter without need for dynamic models. Differential observing strategy requires GPS receiver on user vehicle and network of six ground receivers. Computationally efficient technique delivers decimeter accuracy on orbits down to lowest altitudes. New technique nondynamic long-arc strategy having potential for accuracy of best dynamic techniques while retaining much of computational simplicity of geometric techniques.