gebhart/patrepeval huggingface dataset:
Exploring the Use of Sensors to Measure Behavioral Interactions: An Experimental Evaluation of Using Hand Trajectories (2014)

Humans appear to be sensitive to relative small changes in their surroundings. These changes are often initially perceived as irrelevant, but they can cause significant changes in behavior. However, how exactly people's behavior changes is often hard to quantify. A reliable and valid tool is needed in order to address such a question, ideally measuring an important point of interaction, such as the hand. Wearable-body-sensor systems can be used to obtain valuable, behavioral information. These systems are particularly useful for assessing functional interactions that occur between the endpoints of the upper limbs and our surroundings. A new method is explored that consists of computing hand position using a wearable sensor system and validating it against a gold standard reference measurement (optical tracking device). Initial outcomes related well to the gold standard measurements (r = 0.81) showing an acceptable average root mean square error of 0.09 meters. Subsequently, the use of this approach was further investigated by measuring differences in motor behavior, in response to a changing environment. Three subjects were asked to perform a water pouring task with three slightly different containers. Wavelet analysis was introduced to assess how motor consistency was affected by these small environmental changes. Results showed that the behavioral motor adjustments to a variable environment could be assessed by applying wavelet coherence techniques. Applying these procedures in everyday life, combined with correct research methodologies, can assist in quantifying how environmental changes can cause alterations in our motor behavior.
A Compact, Well-humidified Breathing Circuit for the Circle System (1976)

One of the disadvantages of conventional circle absorber breathing circuits is that twisting between tile inspiratory and expiratory limbs sometimes occurs. In situations where access to the patient's airway is limited, such as during neurosurgical and head and neck operations, this disadvantage may lead to accidental disconnection or extubation. Another is that the temperature and humidity of inspired gas are usually less than desirable, predisposing to heal loss.1 and drying of tracheal mucusa.2 We have constructed a circuit that houses the inspiratory limb entirely within the lumen of a slightly larger expiratory limb. This makes it easy to handle and allows heat exchange between the cold inspired and warmer expired streams. Heat of condensation liberated by condensation of water on the outer surface of the inspiratory limb enhances vaporization of water droplets normally deposited on the inner surface of that limb, thereby increasing inspired humidity.
Dual comparison one cycle control for single phase bi-directional power converters (2016)

In this paper a modification to dual comparison one cycle control is proposed which enables bi-directional power flow in single phase grid connected converters. Advantages of dual comparison one cycle control when compared to conventional one cycle control is that it does not give any steady state dc offset, no light load instability and unipolar pwm without having to sense the grid voltage. Modification to dual comparison one cycle control is the addition of a fictitious current term which is generated, using a band pass filter, from the gating signal of one of the active devices. Quality factor of the band pass filter is shown to impact the total harmonic distortion in current, fundamental displacement angle and steady state dc offset. Optimal value of Q-factor along with a dc offset controller gives a superior performance. Detailed simulation and experimental studies are carried to validate the proposed control and the high performance that can be obtained.
Error tolerant document structure analysis (2002)

Successful applications of digital libraries require structured access to sources of information. This paper presents an approach to extract the logical structure of text documents. The extracted structure is explicated by means of SGML (Standard Generalized Markup Language). Consequently, the extraction is achieved on the basis of grammars that extend SGML with recognition rules. From these grammars parsing automata are generated. These automata are used to partition a flat text document into its elements, to discard formatting information, and to insert SGML markups. Complex document structures and fallback rules needed for error tolerant parsing make such automata highly ambiguous. A novel parsing strategy has been developed that ranks and prunes ambiguous parsing paths.
Behaviour-modifying chemicals: prospects and constraints in IPM. (2004)

This paper presents an overview of the potential role of semiochemicals in integrated pest management strategies, including monitoring, trapping and mating disruption, and provide some examples of successes. It identifies the constraints and future prospects for mating disruption, and discusses efforts on the practical and commercial use of various mating disruption technologies in plant protection.
Measuring High-Slope and Super-Smooth Optics with High-Dynamic-Range Coherence Scanning Interferometry (2014)

Advances in the implementation of coherence scanning interferometry have dramatically extended the range of application for this well-known technique. New data acquisition and data processing methods significantly improve dynamic range, enabling measurements of steeply-sloped surfaces usually considered beyond the reach of high-NA objectives. Hybrid data acquisition incorporating sinusoidally-modulated phase shifting reduces signal-to-noise to the 0.1 nm/√Hz level, extending the technique to super-polished surfaces.
Chlorofluorination reactions of sulphur(IV) fluorides (1969)

Trifluoromethylsulphur chloride tetrafluoride, CF3SF4CI, results from the action of chlorine on CF3SF3 in the presence of caesium fluoride, and CH3N:SF2 reacts with chlorine to give CH2CIN:SF2, CHCI2N:SF2, and CF3N:SCl2.
Total Synthesis of the Pentacyclic Alkaloid Ascididemin (1989)

The antileukemic alkaloid ascididemin (1) was prepared from quinoline-5.8-quinone(Q) by oxidative anination with o-aminoacetophenone ( 3 ) .followed by acid catalysed cyclisation and subsequent one pot annelation o f ring E. Ascididenin (A), a pentacyclic alkaloid with antileukemic activity, was isolated 2 by Kobayashi and co-workers from t h e Okinawan tunicate Oideanum sp. in l a w yield
Fission Yeast Cdc24 Is a Replication Factor C- and Proliferating Cell Nuclear Antigen-Interacting Factor Essential for S-Phase Completion (1999)

At the nonpermissive temperature the fission yeast cdc24-M38 mutant arrests in the cell cycle with incomplete DNA replication as indicated by pulsed-field gel electrophoresis. The cdc24(+) gene encodes a 501-amino-acid protein with no significant homology to any known proteins. The temperature-sensitive cdc24 mutant is effectively rescued by pcn1(+), rfc1(+) (a fission yeast homologue of RFC1), and hhp1(+), which encode the proliferating cell nuclear antigen (PCNA), the large subunit of replication factor C (RFC), and a casein kinase I involved in DNA damage repair, respectively. The Cdc24 protein binds PCNA and RFC1 in vivo, and the domains essential for Cdc24 function and for RFC1 and PCNA binding colocalize in the N-terminal two-thirds of the molecule. In addition, cdc24(+) genetically interacts with the gene encoding the catalytic subunit of DNA polymerase epsilon, which is stimulated by PCNA and RFC, and with those encoding the fission yeast counterparts of Mcm2, Mcm4, and Mcm10. These results indicate that Cdc24 is an RFC- and PCNA-interacting factor required for DNA replication and might serve as a target for regulation.
Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab (2002)

CAMPATH antibodies recognize CD52, a phosphatidylinositol-linked membrane protein expressed by mature lymphocytes and monocytes. Since some antigen-presenting dendritic cells (DCs) differentiate from a monocytic progenitor, we investigated the expression of CD52 on dendritic cell subsets. Four-color staining for lineage markers (CD3, 14, 16, 19, 20, 34, and 56), HLA-DR, CD52, and CD123 or CD11c demonstrated that myeloid peripheral blood (PB) DCs, defined as lineage(-)HLA-DR(+)CD11c(+), express CD52, while expression by CD123(+) lymphoid DCs was variable. Depletion of CD52(+) cells from normal PB strongly inhibited their stimulatory activity in an allogeneic mixed lymphocyte reaction and also reduced the primary autologous response to the potent neoantigen keyhole limpet hemocyanin. CD52 is thus expressed by a myeloid subset of PBDCs that is strongly allostimulatory and capable of initiating a primary immune response to soluble antigen. Administration of alemtuzumab, a humanized monoclonal antibody against CD52, to patients with lymphoproliferative disorders or as conditioning for hematopoietic stem cell transplantation resulted in a marked reduction in circulating lineage(-)HLA-DR(+) DCs (mean 31-fold reduction, P =.043). Analysis of monocyte-derived DCs in vitro revealed a reduction in CD52 expression during culture in granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4, with complete loss following activation-induced maturation with lipopolysaccharide. In contrast to the findings in PB, epidermal and small-intestine DCs did not express CD52, suggesting either that transit from blood to epidermis and gut is associated with loss of CD52 or that DCs in these tissues originate from another population of cells.
Twitter Sentiment Analysis: A Bootstrap Ensemble Framework (2013)

Twitter sentiment analysis has become widely popular. However, stable Twitter sentiment classification performance remains elusive due to several issues: heavy class imbalance in a multi-class problem, representational richness issues for sentiment cues, and the use of diverse colloquial linguistic patterns. These issues are problematic since many forms of social media analytics rely on accurate underlying Twitter sentiments. Accordingly, a text analytics framework is proposed for Twitter sentiment analysis. The framework uses an elaborate bootstrapping ensemble to quell class imbalance, sparsity, and representational richness issues. Experiment results reveal that the proposed approach is more accurate and balanced in its predictions across sentiment classes, as compared to various comparison tools and algorithms. Consequently, the bootstrapping ensemble framework is able to build sentiment time series that are better able to reflect events eliciting strong positive and negative sentiments from users. Considering the importance of Twitter as one of the premiere social media platforms, the results have important implications for social media analytics and social intelligence.
A Novel ATP-Binding Cassette Transporter Involved in Multidrug Resistance in the Phytopathogenic Fungus <i>Penicillium digitatum</i> (1998)

Demethylation inhibitor (DMI)-resistant strains of the plant pathogenic fungus Penicillium digitatum were shown to be simultaneously resistant to cycloheximide, 4-nitroquinoline-N-oxide (4NQO), and acriflavine. A PMR1 (Penicillium multidrug resistance) gene encoding an ATP-binding cassette (ABC) transporter (P-glycoprotein) was cloned from a genomic DNA library of a DMI-resistant strain (LC2) of Penicillium digitatum by heterologous hybridization with a DNA fragment containing an ABC-encoding region from Botrytis cinerea. Sequence analysis revealed significant amino acid homology to the primary structures of PMR1 (protein encoded by the PMR1 gene) and ABC transporters of Saccharomyces cerevisiae (PDR5 and SNQ2), Schizosaccharomyces pombe (HBA2), Candida albicans (CDR1), and Aspergillus nidulans (AtrA and AtrB). Disruption of the PMR1 gene of P. digitatum DMI-resistant strain LC2 demonstrated that PMR1 was an important determinant of resistance to DMIs. The effective concentrations inhibiting radial growth by 50% (EC50s) and the MICs of fenarimol and bitertanol for the PMR1 disruptants (Deltapmr1 mutants) were equivalent to those for DMI-sensitive strains. Northern blot analysis indicated that severalfold more PMR1 transcript accumulated in the DMI-resistant strains compared with those in DMI-sensitive strains in the absence of fungicide. In both DMI-resistant and -sensitive strains, transcription of PMR1 was strongly enhanced within 10 min after treatment with the DMI fungicide triflumizole. These results suggested that the toxicant efflux system comprised of PMR1 participates directly in the DMI resistance of the fungus.
Targeting Different Signaling Pathways with Antisense Oligonucleotides Combination for Cancer Therapy (2007)

The evidence that cancer development is a complex and multistep process, characterized by alterations of genes involved in the regulation of proliferation, apoptosis and angiogenesis, has led to development of new therapeutic strategies based on the use of agents able to selectively inhibit key molecules of these pathways. In particular, antisense oligonucleotides (ASOs) have proved their efficacy as targeted therapy in preclinical studies, have been well tolerated and able to modulate target protein expression in clinical studies. Although these agents have shown considerable promise for antitumoral therapy, treatment with ASOs used as single agent does not seem particularly promising because of the multigenic alterations of tumors. Based on these considerations, approaches based on the combination of ASOs targeting oncogenes involved in different molecular pathways have been investigated. Moreover, the role of this novel strategy when integrated with conventional drugs or signaling inhibitors, has been assessed. This review addresses some advances in the ASOs combination and reports the potential application of this strategy for the treatment of human cancer.
High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines (2016)

Invasive infections by fungal pathogens cause more deaths than malaria worldwide. We found the ergoline compound NGx04 in an antifungal screen, with selectivity over mammalian cells. High-resolution chemogenomics identified the lipid transfer protein Sec14p as the target of NGx04 and compound-resistant mutations in Sec14p define compound-target interactions in the substrate binding pocket of the protein. Beyond its essential lipid transfer function in a variety of pathogenic fungi, Sec14p is also involved in secretion of virulence determinants essential for the pathogenicity of fungi such as Cryptococcus neoformans, making Sec14p an attractive antifungal target. Consistent with this dual function, we demonstrate that NGx04 inhibits the growth of two clinical isolates of C. neoformans and that NGx04-related compounds have equal and even higher potency against C. neoformans. Furthermore NGx04 analogues showed fungicidal activity against a fluconazole resistant C. neoformans strain. In summary, we present genetic evidence that NGx04 inhibits fungal Sec14p and initial data supporting NGx04 as a novel antifungal starting point.
Valence band spectra of aluminum oxides, hydroxides, and oxyhydroxides interpreted by X.alpha. calculations (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTValence band spectra of aluminum oxides, hydroxides, and oxyhydroxides interpreted by X.alpha. calculationsSajan. Thomas and Peter M. A. SherwoodCite this: Anal. Chem. 1992, 64, 21, 2488–2495Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ac00045a006https://doi.org/10.1021/ac00045a006research-articleACS PublicationsRequest reuse permissionsArticle Views1286Altmetric-Citations131LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Practical issues in frequency domain synchronization for filter bank based multicarrier transmission (2008)

In this paper we address the practical problems when dealing with synchronization and channel estimation in a filter bank based multicarrier system. We present an approach for performing timing synchronization, carrier frequency offset estimation and correction, and channel estimation based on the use of the same training sequences for all the three tasks. We show that it is possible to perform them all after the analysis filter bank at the receiver, at low sampling rate, taking advantage of the high selectivity of the subband filters. The possibility to implement all the receiver baseband signal processing functionalities in frequency domain results in a very flexible overall receiver architecture, suitable for dynamic use of the frequency spectrum.
The mobile storefront: let your fingers do the shopping (2005)

The Mobile Storefront Case Study is a view into a project to dramatically improve the retail user experience for shopping and purchasing ringtones, games, pictures, and other content on handsets. The project was inspired by use cases, vision demos, and the pain points experienced by customers.This design case study details a design solution to enhance the user experience that results in changes to the information architecture and navigation model.Usability study results and lessons learned include ideas on how much content is needed to make the testing feel real to subjects as well as how the design fared with users in a live setting.
Lyophilization of chemiluminescent substrate reagents for high-sensitive microchannel-based lateral flow assay (MLFA) in point-of-care (POC) diagnostic system (2019)

Over the last few years, lateral flow assay (LFA) devices have grown to be the most common point-of-care test (POCT) platform facilitating disease diagnostics in low-resource environments. However, the lack of consistency and the limited sensitivity of these devices often lead to misdiagnosis and generates the need for an alternate approach. A chemiluminescence based microchannel-based lateral flow assay (MLFA) in a POCT platform can result in a much higher sensitivity but involves multiple additional steps of liquid reagents for the sequential execution of the signal amplification protocol. One of the best ways to develop a sample-to-answer system with minimum user intervention is to dry reagents on a chip prior to sample addition and to control the flow of the biological fluid through the drying chambers resulting in the reconstitution of the reagents. This work reports the methods for the successful lyophilization of the chemiluminescent substrate and its reconstitution in artificial serum without any significant loss of functionality. The lyophilized reagents were reconstituted and incorporated into the reaction chambers of a designed polymer lab-on-a-chip to implement a sandwich assay for the detection of malarial biomarkers. The results report a limit of detection (LOD) of 5.75 ng mL-1 which is sensitive enough to detect active malarial infection. Successful lyophilization and reconstitution of the chemiluminescent substrate, as reported here, can pave the way towards developing an autonomous POCT system implementing chemiluminescence based sandwich ELISA for enhanced sensitivity, portability, and ease-of-use in resource limited settings.
Enzymatic Browning Inhibited in Fresh and Dried Apple Rings by Pineapple Juice (1993)

ABSTRACT Sliced apple rings were treated with water (control), canned pineapple juice, frozen pineapple juice, ion‐exchanged pineapple juice, frozen orange juice, ascorbic acid, a commercial antibrowning preparation or sodium bisulfite. The rings were either left exposed to air, vacuum packaged, or dehydrated. Browning was measured calorimetrically and by visual examination over extended periods of time. Pineapple juice was an effective browning inhibitor in both fresh and dried apples. Pineapple juice was fractionated using various size and charge separation procedures. All fractions inhibited enzymatic browning of crude apple extracts by at least 26%. Results indicate that the inhibitor is a neutral compound of low molecular weight.
Consolidation and translation regulation: Figure 1. (2012)

mRNA translation, or protein synthesis, is a major component of the transformation of the genetic code into any cellular activity. This complicated, multistep process is divided into three phases: initiation, elongation, and termination. Initiation is the step at which the ribosome is recruited to the mRNA, and is regarded as the major rate-limiting step in translation, while elongation consists of the elongation of the polypeptide chain; both steps are frequent targets for regulation, which is defined as a change in the rate of translation of an mRNA per unit time. In the normal brain, control of translation is a key mechanism for regulation of memory and synaptic plasticity consolidation, i.e., the off-line processing of acquired information. These regulation processes may differ between different brain structures or neuronal populations. Moreover, dysregulation of translation leads to pathological brain function such as memory impairment. Both normal and abnormal function of the translation machinery is believed to lead to translational up-regulation or down-regulation of a subset of mRNAs. However, the identification of these newly synthesized proteins and determination of the rates of protein synthesis or degradation taking place in different neuronal types and compartments at different time points in the brain demand new proteomic methods and system biology approaches. Here, we discuss in detail the relationship between translation regulation and memory or synaptic plasticity consolidation while focusing on a model of cortical-dependent taste learning task and hippocampal-dependent plasticity. In addition, we describe a novel systems biology perspective to better describe consolidation.
Three-Dimensional Shear in Granular Flow (2006)

The evolution of granular shear flow is investigated as a function of height in a split-bottom Couette cell. Using particle tracking, magnetic-resonance imaging, and large-scale simulations, we find a transition in the nature of the shear as a characteristic height H* is exceeded. Below H* there is a central stationary core; above H* we observe the onset of additional axial shear associated with torsional failure. Radial and axial shear profiles are qualitatively different: the radial extent is wide and increases with height, while the axial width remains narrow and fixed.