gebhart/patrepeval huggingface dataset:
Air-filled SIW transmission line and phase shifter for high-performance and low-cost U-Band integrated circuits and systems (2015)

In this paper, air-filled Substrate Integrated Waveguide (SIW) is proposed and demonstrated for the first time at U-band. This low-loss transmission line is developed on a low-cost multilayer Printed Circuit Board (PCB) process. The top and bottom layers may make use of an extremely low-cost standard substrate such as FR-4 on which base-band or digital circuits can be designed so to obtain a very compact, high performance, low-cost and self-packaged integrated system. For measurement purposes, an optimized-length dielectric- to air-filled SIW transition operating at U-band with 0.21 ±0.055 dB insertion loss is developed. The measured insertion loss of an air-filled SIW of interest at U-band is 0.122 ±0.122 dB/cm compared to 0.4 ±0.13 dB/cm for its dielectric-filled counterpart. Furthermore, an air-filled SIW phase shifter is reported for the first time. It achieves a measured 0.15 ±0.14 dB transmission loss at U-band. The proposed air-filled SIW transmission line and phase shifter are of particular interest for high performance and low-cost millimeter-wave circuits and systems.
ATP Release from Mast Cells by Physical Stimulation: A Putative Early Step in Activation of Acupuncture Points (2013)

In Chinese medicine acupuncture points are treated by physical stimuli to counteract various diseases. These stimuli include mechanical stress as applied during the needle manipulation or tuina, high temperatures as applied during moxibustion, and red laser light applied during laser acupuncture. This study aimed to investigate cellular responses to stimuli that might occur in the tissue of acupuncture points. Since they have a characteristically high density of mast cells that degranulate in response to acupuncture, we asked whether these processes lead to ATP release. We tested in in vitro experiments on mast cells of the human mast-cell line HMC-1 the effects of the physical stimuli; mechanical stress was applied by superfusion of the cells with hypotonic solution, heat was applied by incubation of the cells at 52°C, and red laser light of 657 nm was used for irradiation. We demonstrate that all the stimuli induce ATP release from model human mast HMC-1 cells, and this release is associated with an intracellular free Ca(2+) rise. We hypothesize that ATP released from mast cells supplements the already known release of ATP from keratinocytes and, by acting on P2X receptors, it may serve as initial mediator of acupuncture-induced analgesia.
Inference in Deep Gaussian Processes using Stochastic Gradient Hamiltonian Monte Carlo (2018)

Deep Gaussian Processes (DGPs) are hierarchical generalizations of Gaussian Processes that combine well calibrated uncertainty estimates with the high flexibility of multilayer models. One of the biggest challenges with these models is that exact inference is intractable. The current state-of-the-art inference method, Variational Inference (VI), employs a Gaussian approximation to the posterior distribution. This can be a potentially poor unimodal approximation of the generally multimodal posterior. In this work, we provide evidence for the non-Gaussian nature of the posterior and we apply the Stochastic Gradient Hamiltonian Monte Carlo method to generate samples. To efficiently optimize the hyperparameters, we introduce the Moving Window MCEM algorithm. This results in significantly better predictions at a lower computational cost than its VI counterpart. Thus our method establishes a new state-of-the-art for inference in DGPs.
Single‐Phase blends of polycarbonate and poly(phenyl methacrylate) (1992)

Abstract Miscibility studies on blends of polycarbonate (PC) and poly(phenyl methacrylate) (PPMA) were undertaken by means of differential scanning calorimetry (DSC), dynamic mechanical, and dielectric relaxation methods. PC and PPMA were mixed by dissolving in tetrahydrofuran (THE) and subsequently coprecipitated in methanol. DSC studies showed a single glass transition ( T g ) that shifts systematically with composition. These T g s are reproducible in repeated DSC heating cycles, suggesting true miscibility of the pair. The dry PC and PPMA pellets were melt mixed in a Mini‐Mixer/Molder. The extrudates were compression molded. These melt‐mixed PC/PPMA blends exhibited glass like transparency and also showed a single T g in the DSC scans. The true miscibility of PC and PPMA was further confirmed by dynamic mechnaical and dielectric relaxation methods. The net birefringence has been reduced substantially because of the opposite sign of the itrinsic birefringence of PC and PPMA molecules. At the 12/88 PC/PPMA, the birefringence remains zero at all draw ratios, indicating the achievement of birefringence free polymer alloys.
Recognition of Engineer Qualification by the Japan Society of Mechanical Engineers (2001)

With the rapid advancement in technology, engineers are required to keep up with the changing technology. A number of overseas countries have already established support system for practical training of professional engineers after graduation from university. In Japan, the training programs for graduate engineers are mainly conducted in-house by the company and hence the scope of training is relatively narrow. This paper reports on the current limitations of the practical training of the JSME member engineer qualification and proposes possible actions to be adopted by the profession for certification of engineer qualification.
Fast software component migration for applications survivability in distributed real-time systems (2004)

In this paper we propose and evaluate a methodology for run-time fast software component migration for application survivability in distributed real-time systems. For fast migration we focus on the two dominant factors; lightweight migration and proactive resource discovery. The former is to minimize the absolute amount of time required for migration and the latter is to provide a destination host information at the time of migration decision. The run-time software component is implemented as Java object whose class is defined by extending the unicast remote server class. The proactive resource discovery consists of Community protocol and associated algorithms. These two ideas have been implemented as a middleware that also provides a real-time job scheduler in JVM (Java Virtual Machine), and a naming server. Our analysis and simulation in a cluster computing environment show that the proactive resource discovery requires very low communication overhead while maintaining high effectiveness in finding available CPU resources. Our implementation and measurement show that run-time component migration based on our approach takes much less time compared to the approach based on reactive resource discovery
Quadrotor Control Design under Time and State Constraints: Implicit Lyapunov Function Approach (2019)

The problem of a state feedback design for control of a quadrotor system under state and time constraints is studied. Convex embedding approach and Implicit Lyapunov function are employed to design a finite-time controller. The feedback gain is solved by a system of LMIs(Linear Matrix Inequalities). Theoretical results are supported with numerical simulation.
Akt-Induced Cellular Senescence: Implication for Human Disease (2004)

Reduction-of-function mutations in components of the insulin/insulin-like growth factor-1/Akt pathway have been shown to extend the lifespan in organisms ranging from yeast to mice. It has also been reported that activation of Akt induces proliferation and survival of mammalian cells, thereby promoting tumorigenesis. We have recently shown that Akt activity increases with cellular senescence and that inhibition of Akt extends the lifespan of primary cultured human endothelial cells. Constitutive activation of Akt promotes senescence-like arrest of cell growth via a p53/p21-dependent pathway, leading to endothelial dysfunction. This novel role of Akt in regulating the cellular lifespan may contribute to various human diseases including atherosclerosis and diabetes mellitus.
Unidirectional III-V microdisk lasers heterogeneously integrated on SOI (2013)

We demonstrate unidirectional bistability in microdisk lasers electrically pumped and heterogeneously integrated on SOI. The lasers operate in continuous wave regime at room temperature and are single mode. Integrating a passive distributed Bragg reflector (DBR) on the waveguide to which the microdisk is coupled feeds laser emission back into the laser cavity. This introduces an extra unidirectional gain and results in unidirectional emission of the laser, as demonstrated in simulations as well as in experiment.
On-chip direct methanol fuel cells of a monolithic design: consideration on validity of active-type system (2009)

The performance of an on-chip direct methanol fuel cell of monolithic design with an active-type system was improved more than 6-fold up to >100 µW by using hydrogen peroxide as an oxidant solution instead of dissolved oxygen, but the energy-loss caused by strong capillary forces required a redesign of both microchannel size and the system.
A two-stage algorithm for model-based registration of medical images (2002)

Digital subtraction has shown to be the best noninvasive tool for diagnosing small changes of internal structures in medical images. However, subtraction techniques require perfect geometric match. Geometric projection of most medical imaging techniques could be modeled by perspective projection. Eight parameters must be determined for the perspective back-projection of the subsequent image into the geometry of the reference. Perspective invariants which allow the determination of the total eight parameters are still unknown. Therefore, rotations, translations, and scalings (RST-movements) are detected in a first stage using the Fourier-Mellin invariant. This pre-registration allows the linkage of corresponding landmarks in both images by local correlation. In the second stage, the coordinates of automatically detected landmarks are used to determine the perspective parameters for fine-adjustment. The two stages form a robust registration algorithm which is applied to the alignment of intraoral radiographs acquired without individual adjustment aids. The excellent results allow the clinical establishment of the method.
High-voltage auxiliary switchgear for power stations (1989)

Air-break switchgear has been used extensively for many years to control station auxiliaries. Vacuum and SF6 techniques, already well established in the distribution field, are now being applied for the higher ratings and more onerous duties of switchgear in large fossil-fired and nuclear power stations
Modeling of Human Cytomegalovirus Maternal-Fetal Transmission in a Novel Decidual Organ Culture (2011)

Human cytomegalovirus (HCMV) is the leading cause of congenital infection, associated with severe birth defects and intrauterine growth retardation. The mechanism of HCMV transmission via the maternal-fetal interface is largely unknown, and there are no animal models for HCMV. The initial stages of infection are believed to occur in the maternal decidua. Here we employed a novel decidual organ culture, using both clinically derived and laboratory-derived viral strains, for the ex vivo modeling of HCMV transmission in the maternal-fetal interface. Viral spread in the tissue was demonstrated by the progression of infected-cell foci, with a 1.3- to 2-log increase in HCMV DNA and RNA levels between days 2 and 9 postinfection, the expression of immediate-early and late proteins, the appearance of typical histopathological features of natural infection, and dose-dependent inhibition of infection by ganciclovir and acyclovir. HCMV infected a wide range of cells in the decidua, including invasive cytotrophoblasts, macrophages, and endothelial, decidual, and dendritic cells. Cell-to-cell viral spread was revealed by focal extension of infected-cell clusters, inability to recover infectious extracellular virus, and high relative proportions (88 to 93%) of cell-associated viral DNA. Intriguingly, neutralizing HCMV hyperimmune globulins exhibited inhibitory activity against viral spread in the decidua even when added at 24 h postinfection-providing a mechanistic basis for their clinical use in prenatal prevention. The ex vivo-infected decidual cultures offer unique insight into patterns of viral tropism and spread, defining initial stages of congenital HCMV transmission, and can facilitate evaluation of the effects of new antiviral interventions within the maternal-fetal interface milieu.
Technology challenges for advanced Cu CMP using a new slurry free process (2003)

We present an advantage, from the viewpoint of simplicity, in designing the chemical reaction mechanism during chemical-mechanical polishing (CMP) with a new slurry-free CMP process (Sethuraman, 1998; Fayolle et al., 1998). Cu-CMP has been widely reported as one of the leading techniques for Cu interconnect applications. Cu CMP, however, involves several issues such as Cu dishing, Cu recess, oxide erosion and oxide rounding (Steigerwald, 1997). We have previously reported the high performance of a new slurry free Cu-CMP (Matsumoto et al., 1998). Although a large number of studies have been made of Cu-CMP, little is known about the chemical reaction mechanism, since the conventional technique using slurry and a porous pad has a complex mechanism, i.e. the cohesion of abrasive particles and chemical reaction. Therefore, to solve these issues, this paper reports the mechanism and performance of a new slurry-free Cu-CMP technique. We conclude that dishing and erosion issues can be solved by means of the chemical approach in a new slurry free Cu-CMP technique.
Reductions in levels of the Alzheimer's amyloid β peptide after oral administration of ginsenosides (2006)

For millennia, ginseng and some of its components have been used to treat a wide variety of medical conditions, including age-related memory impairment. Because of its purported effects and apparently low rate of side effects, ginseng remains one of the top selling natural product remedies in the United States. Given its potential role for improving age-related memory impairments and its common use in China for the treatment of Alzheimer's disease-like symptoms, we analyzed the effects of commercially available preparations of ginseng on the accumulation of the Alzheimer's amyloid beta peptide (Abeta) in a cell-based model system. In this model system, ginseng treatment resulted in a significant reduction in the levels of Abeta in the conditioned medium. We next examined the effects of several compounds isolated from ginseng and found that certain ginsenosides lowered Abeta concentration in a dose-dependent manner with ginsenoside Rg3 having an approximate IC50 of under 25 microM against Abeta42. Furthermore, we found that three of these isolated components, ginsenoside Rg1, Rg3, and RE, resulted in significant reductions in the amount of Abeta detected in the brains of animals after single oral doses of these agents. The results indicate that ginseng itself, or purified ginsenosides, may have similarly useful effects in human disease.
A tunable concurrent 6-to-18GHz phased-array system in CMOS (2008)

This paper presents a scalable phased-array receiver system that covers a tritave bandwidth of 6-to-18 GHz implemented in a 130nm CMOS process. The single receiver element with a 10-bit phase shifting resolution achieves a maximum phase error of 2.5° within a baseband amplitude variation of 1.5dB for an arbitrary target angle. This dense interpolation provides excellent phase error/offset calibration capability in the array. A 4-element electrical array pattern is measured at 6GHz, 13.5GHz and 18GHz, showing a worst case peak-to-null ratio of 21.5dB. The EVM and phase noise improvements of the array compared with the single receiver element are also shown.
Cultivation Techniques and Medicinal Properties of Pleurotus spp. (2007)

The genus Pleurotus (oyster mushroom) comprises some most popular edible mushrooms due to their favourable organoleptic and medicinal properties, vigorous growth and undemanding cultivation conditions. It can be cultivated on log and a wide variety of agroforestry (by-)products, weeds and wastes for the production of food, feed, enzymes and medicinal compounds, or for waste degradation and detoxification. Many different techniques and substrates have been successfully utilized for mushroom cultivation and biomass production by means of solid-state and submerged liquid fermentation. However, in contrast to submerged liquid fermentation, solid-state fermentation is not often used in large scale due to severe engineering problems. Various Pleurotus species have been shown to possess a number of medicinal properties, such as antitumour, immunomodulatory, antigenotoxic, antioxidant, anti-inflammatory, hypocholesterolaemic, antihypertensive, antiplatelet-aggregating, antihyperglycaemic, antimicrobial and antiviral activities. These therapeutic activities are exhibited by extracts or isolated compounds from Pleurotus spp. fermentation broth, mycelia and fruiting bodies. In particular, polysaccharides appear to be potent antitumour and immuno-enhancing substances, besides possessing other beneficial activities. However, the biochemical mechanisms of these therapeutic activities still remain largely unknown. This review focuses on recent advances in the biotechnology of Pleurotus spp., with emphasis on the production of fruiting bodies, the production of mycelium and bioactive compounds by solid-state and submerged liquid fermentation. The medicinal properties of this mushroom are also outlined.
Odorants as cell‐type specific activators of a heat shock response in the rat olfactory mucosa (2001)

Heat shock, or stress, proteins (HSPs) are induced in response to conditions that cause protein denaturation. Activation of cellular stress responses as a protective and survival mechanism is often associated with chemical exposure. One interface between the body and the external environment and chemical or biological agents therein is the olfactory epithelium (OE). To determine whether environmental odorants affect OE HSP expression, rats were exposed to a variety of odorants added to the cage bedding. Odorant exposure led to transient, selective induction of HSP70, HSC70, HSP25, and ubiquitin immunoreactivities (IRs) in supporting cells and subepithelial Bowman's gland acinar cells, two OE non-neuronal cell populations involved with inhalant biotransformation, detoxification, and maintenance of overall OE integrity. Responses exhibited odor specificity and dose dependency. HSP70 and HSC70 IRs occurred throughout the apical region of supporting cells; ubiquitin IR was confined to a supranuclear cone-shaped region. Electron microscopic examination confirmed these observations and, additionally, revealed odor-induced formation of dense vesicular arrays in the cone-like regions. HSP25 IR occurred throughout the entire supporting cell cytoplasm. In contrast to classical stress responses, in which the entire array of stress proteins is induced, no increases in HSP40 and HSP90 IRs were observed. Extended exposure to higher odorant doses caused prolonged activation of the same HSP subset in the non-neuronal cells and severe morphological damage in both supporting cells and olfactory receptor neurons (ORNs), suggesting that non-neuronal cytoprotective stress response mechanisms had been overwhelmed and could no longer adequately maintain OE integrity. Significantly, ORNs showed no stress responses in any of our studies. These findings suggest a novel role for these HSPs in olfaction and, in turn, possible involvement in other normal neurophysiological processes.
Textural, Color, and Sensory Properties of Bologna Containing Various Levels of Washed Chicken Skin (1996)

Poultry skin was washed in sodium bicarbonate (0.5%) solution in a pilot plant facility to remove fat from skin. Composition of the washed product was determined and its functional properties were determined in a bologna product at the levels of 0, 10, and 20%. Washing reduced fat, and increased total protein and moisture in skin. Collagen content was significantly increased and water- and salt-soluble protein in washed skin were significantly decreased compared to unwashed skin (P < 0.05). With reference to emulsion stability, skin content did not affect fat or gel-water losses and lowered solids loss when compared to bologna with 0% skin (P < 0.05). Kramer Shear peak force was not significantly different for bologna at each treatment level. Total energy was higher for bologna with 0% skin (P < 0.05). Skin addition did not affect compression measurements of hardness, springiness, cohesiveness, and chewiness when compared to bologna with 0% skin. The addition of skin resulted in a lighter (L), less red (aL), and less yellow (bL) product according to HunterLab color analysis (P < 0.05). Consumer panelists rated bologna with 10% skin highest in texture, flavor, and texture and appearance acceptability (P < 0.05). Washed chicken skin may have potential as a low cost, low fat ingredient for emulsified meat products.
Ligand binding to heparan sulfate proteoglycans induces their aggregation and distribution along actin cytoskeleton. (1996)

Cell surface heparan sulfate proteoglycans (HSPGs) participate in molecular events that regulate cell adhesion, migration, and proliferation. The present study demonstrates that soluble heparin-binding proteins or cross-linking antibodies induce the aggregation of cell surface HSPGs and their distribution along underlying actin filaments. Immunofluorescence and confocal microscopy and immunogold and electron microscopy indicate that, in the absence of ligands, HSPGs are irregularly distributed on the fibroblast cell surface, without any apparent codistribution with the actin cytoskeleton. In the presence of ligand (lipoprotein lipase) or antibodies against heparan sulfate, HSPGs aggregate and colocalize with the actin cytoskeleton. Triton X-100 extraction and immunoelectron microscopy have demonstrated that in this condition HSPGs were clustered and associated with the actin filaments. Crosslinking experiments that use biotinylated lipoprotein lipase have revealed three major proteoglycans as binding sites at the fibroblast cell surface. These cross-linked proteoglycans appeared in the Triton X-100 insoluble fraction. Platinum/carbon replicas of the fibroblast surface incubated either with lipoprotein lipase or antiheparan sulfate showed large aggregates of HSPGs regularly distributed along cytoplasmic fibers. Quantification of the spacing between HSPGs by confocal microscopy confirmed that the nonrandom distribution of HSPG aggregates along the actin cytoskeleton was induced by ligand binding. When cells were incubated either with lipoprotein lipase or antibodies against heparan sulfate, the distance between immunofluorescence spots was uniform. In contrast, the spacing between HSPGs on fixed cells not incubated with ligand was more variable. This highly organized spatial relationship between actin and proteoglycans suggests that cortical actin filaments could organize the molecular machinery involved in signal transduction and molecular movements on the cell surface that are triggered by heparin-binding proteins.