gebhart/patrepeval huggingface dataset:
Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study (2021)

The COVID-19 disease is a multisystem disease due in part to the vascular endothelium injury. Lasting effects and long-term sequelae could persist after the infection and may be due to persistent endothelial dysfunction. Our study focused on the evaluation of endothelial quality index (EQI) by finger thermal monitoring with E4 diagnosis Polymath in a large cohort of long COVID-19 patients to determine whether long-covid 19 symptoms are associated with endothelial dysfunction. This is a cross-sectional multicenter observational study with prospective recruitment of patients. A total of 798 patients were included in this study. A total of 618 patients (77.4%) had long COVID-19 symptoms. The mean EQI was 2.02 ± 0.99 IC<sub>95%</sub> [1.95<b>-</b>2.08]. A total of 397 (49.7%) patients had impaired EQI. Fatigue, chest pain, and neuro-cognitive difficulties were significantly associated with endothelium dysfunction with an EQI <2 after adjustment for age, sex, diabetes, hypertension, dyslipidemia, coronary heart disease, and the severity of acute COVID-19 infection. In multivariate analysis, endothelial dysfunction (EQI <2), female gender, and severe clinical status at acute COVID-19 infection with a need for oxygen supplementation were independent risk factors of long COVID-19 syndrome. Long COVID-19 symptoms, specifically non-respiratory symptoms, are due to persistent endothelial dysfunction. These findings allow for better care of patients with long COVID-19 symptoms.
Performance Prediction for Coarse-Grained Locking (2019)

A standard design pattern found in many concurrent data structures, such as hash tables or ordered containers, is an alternation of parallelizable sections that incur no data conflicts and critical sections that must run sequentially and are protected with locks. A lock can be viewed as a queue that arbitrates the order in which the critical sections are executed, and a natural question is whether we can use stochastic analysis to predict the resulting throughput. As a preliminary evidence to the affirmative, we describe a simple model that can be used to predict the throughput of coarse-grained lock-based algorithms. We show that our model works well for CLH lock, and we expect it to work for other popular lock designs such as TTAS, MCS, etc.
Effects of cardiac work on electrical potential gradient across mitochondrial membrane in perfused rat hearts (1993)

The myocardium responds to alterations in cardiac work by changing its rate of O2 consumption. This reflects an increase in the oxidative synthesis of ATP to meet the contractile demand for ATP. However, the biochemical mechanisms responsible for increased ATP synthesis are not fully understood. To localize the flux-controlling reaction(s) in the pathway of ATP synthesis, the effects of substrates and cardiac work on mitochondrial membrane potential (delta psi m), total tissue NADH-to-NAD+ ratio, and high-energy phosphate metabolites were examined in perfused rat hearts. Delta psi m was measured using the equilibrium distribution of tetraphenylphosphonium (33). Cytosolic phosphorylation potential, total tissue NADH-to-NAD+ ratio, and delta psi m were higher in hearts perfused with pyruvate than in those perfused with glucose. Increasing cardiac work induced a four-fold increase in O2 consumption, which was accompanied by 1) decreased or unaltered cytosolic ADP concentration, 2) increased tissue NADH-to-NAD+ ratio, and 3) decreased delta psi m. The results indicate that both NADH-generating reactions and the ATP synthase-catalyzed reaction are important in causing the increase in respiration that accompanies increased work. Because the activation of ATP synthase by cardiac work occurred in the absence of increases in delta psi m, ADP, and Pi, it is possible that the work-related acceleration in ATP synthesis may be due to modification of the kinetic properties of the ATP synthase.
Inhibition of epidermal growth factor-induced cellular proliferation. (1987)

The authors tested whether two oncogenic poxviruses, Shope fibroma virus (SFV) and malignant rabbit fibroma virus (MV), coded for an epidermal growth factor (EGF)-like protein. Virus-free lysates of SFV or MV-infected rabbit kidney cells do not appreciably affect proliferation of EGF-unresponsive RK-13 cells. Comparable lysates inhibit the background proliferation of two EGF-responsive cell lines, human foreskin fibroblasts and normal rat kidney cells. Inhibition of EGF-stimulated proliferation is also observed in a dose-dependent fashion. This inhibition is greatest when the virus lysate preparations are added either simultaneously with or before EGF. When EGF is added to cultures 24 hours before the SFV or MV preparations, the latter then have little or no effect on EGF-induced target cell proliferation. The inhibitory factor competed with radiolabeled EGF for its receptor site. Electroblotting shows a protein of 35 kd molecular weight in the lysates of virus-infected RK-13 cells which reacts with anti-EGF antibody. These findings interpreted to indicate that SFV and MV code for an inhibitor of EGF activity, and that this inhibition occurs at least in part by competitive inhibition of EGF-EGF receptor interactions.
Reduced Cell Surface Expression of HLA-C Molecules Correlates with Restricted Peptide Binding and Stable TAP Interaction (1998)

HLA-C molecules are poorly expressed at the cell surface compared with HLA-A and HLA-B locus products. The reason for the low surface expression and the underlying mechanism is unclear. We show that the HLA-C4 allele is expressed intracellularly in amounts similar to HLA-A and HLA-B alleles. However, the majority of the HLA-C4 molecules is not transported, but is retained in the endoplasmic reticulum by stable interaction with TAP. This pool does not appear to participate in the formation of HLA-C4/peptide complexes, but is degraded in the endoplasmic reticulum. HLA-C4 molecules can dissociate from TAP upon binding of specific peptide. However, they require a 10-fold higher concentration of a completely degenerated 9-mer peptide mixture for release from TAP than the HLA-A and HLA-B alleles. Our data show that the HLA-C molecules tested are more selective in their peptide binding than HLA-A and HLA-B molecules, resulting in prolonged association with TAP and a reduced formation of intracellular HLA-C/peptide complexes. The restricted peptide binding of certain HLA-C alleles provides one explanation for the reduced expression of HLA-C molecules at the cell surface. Other mechanisms will be discussed.
Influence of the mixing ratio on antibacterial characteristics of MgO-ZnO solid solution in two phase coexistence region (2008)

Though occurrence of the antibacterial activity on some oxides, MgO and ZnO, is well-known, it is not clear what the mixing ratio among solid solutions affects antibacterial activity. In present work, change in antibacterial activity with the mixing ratio of two-type solid solutions, Mg1-XZnXO with cubic structure and Zn1-XMgXO with hexagonal structure, was studied. After MgO and ZnO powders were mixed with the molar ratio (MgO/ZnO) of 0.44, 1.22 and 1.86, the solid solutions were obtained by heating at 1200°C for 5 h in air. By X-ray diffraction measurement, it was found that two-type solid solutions of cubic and hexagonal structure were formed at the molar ratio of 1.22-0.44. The formation amount of cubic-type solid solution increased with increasing the molar ratio. At the molar ratio of 1.86, cubic-type solid solution was formed without any hexagonal-type. In three powder samples of the obtained solid solutions, antibacterial characteristics were examined by colony count method, using Staphylococcus aureus and Escherichia coli. In the case of the mixture of cubic- and hexagonal-type solid solutions, antibacterial activity enhanced with increasing the formation amount of cubic-type solid solution. The powder sample with a single phase of cubic-type solid solution showed strongest antibacterial activity in three powder samples. As mentioned above, the mixing ratio of two-type solid solutions with cubic and hexagonal structure was found to affect antibacterial activity.
Extension of the Haseman–Elston method to multiple alleles and multiple loci: theory and practice for candidate genes (1997)

The Haseman & Elston (1972) sibling‐pair regression method has been used to detect and estimate the variance contribution to observed values of a quantitative trait by allelic variation in specific candidate genes. The procedure was developed under a model with a single biallelic trait locus. This assumption does not hold for several known systems. In this paper we prove that for candidate gene analysis the Haseman–Elston procedure extends to the case of multiple trait loci, each possibly having more than two alleles. Simulation experiments comparing single‐locus to two‐locus models show that fitting the extended regression equations maintains nominal significance levels, but the power to detect linkage to trait variation is not improved by including additional loci. These results indicate that the original proposal is statistically robust to violations of the underlying genetic model. Practical issues associated with quantifying the relative variance contribution by individual loci are also discussed. Applications of the extended regression equations to lipoprotein(a) and high density lipoprotein cholesterol are given for illustration.
Fibrous Foreign Body Obstruction of the Small Colon in Young Horses (1980)

During a 2 year period, 2 horses from the same farm were admitted to the Iowa State University Large Animal Hospital exhibiting signs of mild to moderate abdominal pain. Upon surgical exploration both horses were found to have a fibrous foreign body obstruction of the small colon. Intestinal resection and anastomosis successfully relieved the obstruction in both cases. It was determined that both obstructions were composed of synthetic fencing material.
Size Reduction and Rating Extension of Magnetic Air Circuit Breakers up to 500,000 Kva, 15 Kv (1946)

AIR CIRCUIT BREAKERS rapidly are becoming the standard of the industry for voltages up to 15,000 volts and for kilovolt-ampere ratings of 50,000 to 500,000 kva. Their general desirability as compared to oil-type switchgear is now recognized by most users.
Breast density classification with deep convolutional neural networks (2017)

Breast density classification is an essential part of breast cancer screening. Although a lot of prior work considered this problem as a task for learning algorithms, to our knowledge, all of them used small and not clinically realistic data both for training and evaluation of their models. In this work, we explore the limits of this task with a data set coming from over 200,000 breast cancer screening exams. We use this data to train and evaluate a strong convolutional neural network classifier. In a reader study, we find that our model can perform this task comparably to a human expert.
Optical shutter driven photochemically from anisotropic polymer network containing liquid crystalline and azobenzene molecules (1998)

Polymer-dispersed liquid crystal (PDLC) with macroscopically uniaxial molecular alignment containing azobenzene molecules was produced. The PDLC was transparent because of this alignment. Upon photoirradiation to cause trans-cis photoisomerization of azobenzene molecules, the PDLC became translucent even at 30 °C. The PDLC system does not require the use of polarizers and electrodes to fabricate optical devices. The light scattering is ascribed to a biphasic morphology in the system produced transiently by means of the photochemical phase transition.
The tyrosinase gene family--interactions of melanogenic proteins to regulate melanogenesis. (1994)

Several genes critical to the regulation of melanin production in mammals have recently been cloned and characterized. They map to the albino, brown, and slaty loci in mice, and encode proteins with similar structures and features, but with distinct catalytic capacities. The albino locus encodes tyrosinase, an enzyme with three distinct melanogenic functions, the brown locus encodes TRP1 (tyrosinase-related protein-1), and the slaty locus encodes TRP2, another tyrosinase related-protein. TRP2 functions as DOPAchrome tautomerase, an enzyme that preserves the carboxylic acid content of melanins, which would be spontaneously lost in its absence, while TRP1 is able to oxidize the DHICA produced by TRP2. In this study we have used three different systems (immune-affinity purified melanogenic enzymes, mutant melanocytes, and transfected cells) to examine the enzymatic interactions of these proteins, and their stabilization in a complex which significantly increases their physiological half-life. When extrapolated to the melanocyte, our results demonstrate the catalytic functions of these proteins and suggest how they might stably interact within a melanogenic complex in the melanosome to regulate the quantity and quality of melanin synthesized.
An overview of the history, applications, advantages, disadvantages and prospects of gene therapy. (2016)

Gene therapy has become a significant issue in science-related news. The principal concept of gene therapy is an experimental technique that uses genes to treat or prevent disease. Although gene therapy was originally conceived as a way to treat life-threatening disorders (inborn defects, cancers) refractory to conventional treatment, it is now considered for many nonlife-threatening conditions, such as those adversely impacting a patients quality of life. An extensive range of efficacious vectors, delivery techniques, and approaches for developing gene-based interventions for diseases have evolved in the last decade. The lack of suitable treatment has become a rational basis for extending the scope of gene therapy. The aim of this review is to investigate the general methods by which genes are transferred and to give an overview to clinical applications. Maximizing the potential benefits of gene therapy requires efficient and sustained therapeutic gene expression in target cells, low toxicity, and a high safety profile. Gene therapy has made substantial progress albeit much slower than was initially predicted. This review also describes the basic science associated with many gene therapy vectors and the present progress of gene therapy carried out for various surface disorders and diseases. The conclusion is that, with increased pathobiological understanding and biotechnological improvements, gene therapy will become a standard part of clinical practice.
Mobile video delivery with HTTP (2011)

Expansion in 3G cellular coverage and the emergence of more powerful mobile devices has increased demand for massively scalable mobile video delivery. The rapid adoption of the third screen as a primary screen for video has highlighted inefficiencies in the mobile delivery ecosystem and scalability issues in the mobile delivery infrastructure. This article provides an overview of the current mobile content delivery ecosystem and discusses the expanding role of HTTP-based mobile video delivery. A new class of HTTP-based mobile delivery protocols seeks to address existing quality and scalability issues by simplifying and standardizing mobile video delivery. This article shows how segment-based delivery has enabled HTTP-based live streaming and dynamic bitrate adaptation while increasing scalability through the use of existing CDN infrastructure.
Stille Coupling Made Easier—The Synergic Effect of Copper(<scp>I</scp>) Salts and the Fluoride Ion (2004)

CsF and CuI do the trick: Stille coupling reactions of aryl/vinyl iodides, triflates, and bromides with aryl/vinyl stannanes are greatly enhanced by the inclusion of CsF and CuI in the reaction mixture (see scheme; Conditions A: [Pd(PPh3)4]/CsF/CuI/DMF/45 °C; Conditions B: PdCl2/PtBu3/CsF/CuI/DMF/45 °C).
Three-Dimensional Quasi-linear Electromagnetic Modeling and Inversion (1999)

Summary The quasi-linear (QL) approximation replaces the (unknown) total field in the integral equation of electromagnetic (EM) scattering with a linear transformation of the primary field. This transformation involves the product of the primary field with a reflectivity tensor, which is assumed to vary slowly inside inhomogeneous regions and therefore can be determined numerically on a coarse grid by a simple optimization. The QL approximation predicts EM responses accurately over a wide range of frequencies for conductivity contrasts of more than 100 to 1 between the scatterer and the background medium. It also provides a fast-forward model for 3-D EM inversion. The inversion equation is linear with respect to a modified material property tensor, which is the product of the reflectivity tensor and the anomalous conductivity. We call the (regularized) solution of this equation a quasi-Born inversion. The material property tensor (obtained by inversion of the data) then is used to estimate the reflectivity tensor inside the inhomogeneous region and, in turn, the anomalous conductivity. Solution of the nonlinear inverse problem thus proceeds through a set of linear equations. In practice, we accomplish this inversion through gradient minimization of a cost function that measures the error in the equations and includes a regularization term. We use synthetic experiments with plane-wave and controlled sources to demonstrate the accuracy and speed of the method.
The ear as a location for wearable vital signs monitoring (2010)

Obtaining vital signs non-invasively and in a wearable manner is essential for personal health monitoring. We propose the site behind the ear as a location for an integrated wearable vital signs monitor. This location is ideal for both physiological and mechanical reasons. Physiologically, the reflectance photoplethysmograph (PPG) signal behind the ear shows similar signal quality when compared to traditional finger transmission PPG measurements. Ballistocardiogram (BCG) can be obtained behind the ear using 25mm×25mm differential capacitive electrodes constructed using fabric. The BCG signal is able to provide continuous heart rate and respiratory rate, and correlates to cardiac output and blood pressure. Mechanically, the ear remains in the same orientation relative to the heart when upright, thus simplifying pulse transit time calculations. Furthermore, the ear provides a discreet and natural anchoring point that reduces device visibility and the need for adhesives.
Conversion Potential of Marrow Cells into Lung Cells Fluctuates with Cytokine-Induced Cell Cycle (2008)

Green fluorescent protein (GFP)-labeled marrow cells transplanted into lethally irradiated mice can be detected in the lungs of transplanted mice and have been shown to express lung-specific proteins while lacking the expression of hematopoietic markers. We have studied marrow cells induced to transit the cell cycle by exposure to interleukin-3 (IL-3), IL-6, IL-11, and Steel factor at different times of culture corresponding to different phases of cell cycle. We have found that marrow cells at the G(1)/S interface of the cell cycle have a three-fold increase in cells that assume a nonhematopoietic or pulmonary epithelial cell phenotype and that this increase is no longer seen in late S/G(2). These cells have been characterized as GFP(+) CD45(-) and GFP(+) cytokeratin(+). Thus, marrow cells with the capacity to convert into cells with a lung phenotype after transplantation show a reversible increase with cytokine-induced cell cycle transit. Previous studies have shown that the phenotype of bone marrow stem cells fluctuates reversibly as these cells traverse the cell cycle, leading to a continuum model of stem cell regulation. The present study indicates that marrow stem cell production of nonhematopoietic cells also fluctuates on a continuum.
Stereoselective Synthesis of (1<i>R</i>,2<i>S</i>,3<i>R</i>)-Camphordiamine (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTStereoselective Synthesis of (1R,2S,3R)-CamphordiamineCarl A. Busacca, Scot Campbell, Yong Dong, Danja Grossbach, Mike Ridges, Lana Smith, and Earl SpinelliView Author Information Departments of Chemical Development and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut [email protected]Cite this: J. Org. Chem. 2000, 65, 15, 4753–4755Publication Date (Web):June 13, 2000Publication History Received15 February 2000Published online13 June 2000Published inissue 1 July 2000https://pubs.acs.org/doi/10.1021/jo0002137https://doi.org/10.1021/jo0002137brief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views795Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical synthesis,Nuclear magnetic resonance spectroscopy,Redox reactions,Salts,Stereochemistry Get e-Alerts
Chlamydial Infections (1988)

Chlamydia trachomatis infection is the most prevalent sexually transmitted disease in developed countries today. It produces a number of oculogenital syndromes in adults as well as conjunctivitis and pneumonitis in infants. However, the most important sequelae are infertility, ectopic pregnancy, and chronic pelvic pain in women. Available diagnostic tests including culture are less than 100% sensitive but may be of considerable value in detecting asymptomatically infected individuals. Antichlamydial therapy is usually effective and should be given empirically to individuals whose presentation places them at high risk for infection.
Diferentes formas de calcular el remonte de la ola frente a la estructura (2012)

Cuba por su condición de isla se ve afectada constantemente por diferentes fenómenos meteorológicos adversos que atacan sus costas y provocan grandes daños. El cálculo del remonte de la ola resulta imprescindible para el cálculo de la cota de corona de las estructuras de protección costera. En el presente trabajo se exponen los resultados de varios investigadores para el calculo del remonte, lo cual le permite al especialista en esta rama de la Ingeniería Hidráulica calcular dicho fenómeno en función de los diferentes parámetros que en el intervienen. Palabras claves: Rompeolas, trepada, remonte, estructuras costeras