gebhart/patrepeval huggingface dataset:
Depth-presorted triangle lists (2012)

We present a novel approach for real-time rendering of static 3D models front-to-back or back-to-front relative to any viewpoint outside its bounding volume. The approach renders depth-sorted triangles using a single draw-call. At run-time, we replace the traditional sorting strategy of existing algorithms with a faster triangle selection strategy. The selection process operates on an extended sequence of triangles annotated by test planes, created by our off-line preprocessing stage. Based on these test planes, a simple run-time procedure uses the given viewpoint to select a subsequence of triangles for rasterization. Selected subsequences are statically presorted by depth and contain each input triangle exactly once. Our method runs on legacy hardware and renders depth-sorted static models significantly faster than previous approaches. We conclude demonstrating the real-time rendering of order-independent transparency effects.
FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin (2012)

Serotonin is a critical regulator of bone mass, fulfilling different functions depending on its site of synthesis. Brain-derived serotonin promotes osteoblast proliferation, whereas duodenal-derived serotonin suppresses it. To understand the molecular mechanisms of duodenal-derived serotonin action on osteoblasts, we explored its transcriptional mediation in mice. We found that the transcription factor FOXO1 is a crucial determinant of the effects of duodenum-derived serotonin on bone formation We identified two key FOXO1 complexes in osteoblasts, one with the transcription factor cAMP-responsive element-binding protein 1 (CREB) and another with activating transcription factor 4 (ATF4). Under normal levels of circulating serotonin, the proliferative activity of FOXO1 was promoted by a balance between its interaction with CREB and ATF4. However, high circulating serotonin levels prevented the association of FOXO1 with CREB, resulting in suppressed osteoblast proliferation. These observations identify FOXO1 as the molecular node of an intricate transcriptional machinery that confers the signal of duodenal-derived serotonin to inhibit bone formation.
Anti-Inflammatory Effect of Oolong Tea Polyphenols (1998)

The anti-inflammatory activity of aqueous oolong tea extract was tested. The formation of edema caused in rats paws by injection of carrageenin was effectively depressed by soaking the rat paws in hot oolong tea extract. It gives 60% inhibition at the dose of 75 ppm of oolong tea extract. Oolong tea extract showed higher anti-inflammatory activity than those of green and black tea extracts. The active components were found to be catechins and oolong tea tannin (oxidative products of catechin in oolong tea) fractionated from aqueous oolong tea extract. By oral administration of oolong tea extract, carrageenin-induced inflammation was also inhibited, but the anti-inflammatory avtivity by oral administration was lower than by the soaking treatment. The inflammatory activity of percutaneous absorbed oolong tea polyphenols was assumed to be due, at least partly, to the inhibition of prostaglandin biosynthesis in rat tissue injected with carrageenin.
Measurement of free and complexed soluble vascular endothelial growth factor receptor, Flt-1, in fluid samples: development and application of two new immunoassays (2001)

Vascular endothelial growth factor (VEGF) mediates endothelial cell mitogenesis and enhances vascular permeability. VEGF interacts with the endothelium via two membrane-spanning receptors, fms-like tyrosine kinase (Flt)-1 and kinase domain receptor. A soluble form of Flt-1 (sFlt-1) was isolated from endothelial cell media; however, its biological significance is still unknown, with limited data on plasma sFlt-1 levels in disease states. We have developed two new ELISAs for detecting free and VEGF-complexed sFlt-1, which were tested in accordance with standard validation and assessment methodologies employed in commercial settings. The intra-and inter-assay coefficients of variation are < 5% and 10% respectively, and results are highly reproducible. Applying these ELISAs in a clinical setting, we measured levels of VEGF, free and complexed sFlt-1 in citrated plasma from 40 patients with cardiovascular disease and 40 healthy controls. Median (interquartile range) plasma levels of VEGF in patients were significantly greater than controls [403 pg/ml (158–925 pg/ml) versus 113 pg/ml (33–231 pg/ml), P ⩽ 0.05]. Free sFlt-1 was significantly lower in patients compared with controls [8 ng/ml (2–22 ng/ml) versus 21 ng/ml (10–73 ng/ml), P ⩽ 0.05]. There was no significant difference in the levels of complexed sFlt-1 between the two groups. Plasma levels of VEGF-complexed sFlt-1 are minimal, despite the presence of excess free sFlt-1. Thus unbound plasma VEGF detected by ELISA may represent the majority of circulating VEGF, and justifies the measurement of plasma VEGF as an indicator of circulating VEGF levels. Furthermore, these results suggest that circulating sFlt-1 may serve as a selective inhibitor of VEGF activity, and that this regulatory mechanism may be altered by pathological conditions.
SpiderCast (2007)

We introduce SpiderCast, a distributed protocol for constructing scalable churn-resistant overlay topologies for supporting decentralized topic-based pub/sub communication. SpiderCast is designed to effectively tread the balance between average overlay degree and communication cost of event dissemination. It employs a novel coverage-optimizing heuristic in which the nodes utilize partial subscription views (provided by a decentralized membership service) to reduce the average node degree while guaranteeing (with high probability) that the events posted on each topic can be routed solely through the nodes interested in this topic (in other words, the overlay is topic-connected). SpiderCast is unique in maintaining an overlay topology that scales well with the average number of topics a node is subscribed to, assuming the subscriptions are correlated insofar as found in most typical workloads. Furthermore, the degree grows logarithmically in the total number of topics, and slowly decreases as the number of nodes increases.
Performance of Axial Electric Submersible Pumps in a Gassy Well (1992)

ABSTRACT This is a continuation of the earlier work on the I-42B pump presented by Sachdeva1. The dynamic model developed earlier is extended to include axial geometries. Correlations are developed for CD/rb -- the only correlating factor required to complete the model. The performance of radial C-72 and axial K-70 pumps under gassy conditions is studied. Besides the dynamic model, a simple correlation (Model 2) for predicting the pressure rise per stage is also developed for the C-72, K-70 and I-42 pumps.
Experimental Demonstration of the Dependence of the First Hyperpolarizability of Donor-Acceptor-Substituted Polyenes on the Ground-State Polarization and Bond Length Alternation (1994)

It has been suggested that optimizing the first hyperpolarizability, β, of donor-acceptor compounds requires a specific donor-acceptor strength for a given conjugated bridge. For donor-acceptor polyenes, β can be maximized when an optimal degree of mixing between neutral and charge-separated canonical resonance forms This degree of mixing is related to the donor-acceptor strength and a molecular parameter, bond length alternation (BLA), defined as the difference between the average carbon-carbon single and double bond lengths in the polymethine backbone. The degree of BLA arises from the linear combination, or mixing, of the two-limiting charge-transfer resonance forms of the molecule (Figure 1).4 For unsubstituted polyenes or chromophores with weak donors-acceptors, the neutral canonical form is the dominant contributor to the ground state, resulting in large positive BLA. As the donor-acceptor strength increases, the charge-separated resonance structure contributes more to the ground state, resulting in smaller BLA, until both resonance forms contribute equally and the ground-state structure possesses essentially zero BLA, analogous to a symmetrical cyanine. Increasing the ground-state polarization further results in the charge-separated canonical form dominating the ground-state structure, leading to negative BLA.
Electronic network synthesis of linear algebraic matrix equations (1960)

Applications of matrix techniques to the electronic network synthesis of several types of equations have been discussed in previous publications.1-5 A brief review of the basic theory is included in the Appendix. The objective of this paper is to apply these techniques to the synthesis of linear algebraic matrix equations. Existing methods are summarized and their domain of usefulness is indicated, particularly with respect to network stability.
Brand governance practices in Canadian national sport organizations: an exploratory study (2019)

Research Questions: We explored if and how decision-makers of different types of national sport organizations (NSOs) govern their brand, considering the changing landscape and the role of stakeholders and social media. The three research questions were: (RQ1) Do leaders of NSOs include brand governance in their overall governance?; (RQ2) How important is the relationship between the NSOs and their stakeholders for NSOs’ brand governance?; (RQ3) How does social media contribute to NSOs’ brand governance?Research methods: Thirty-two chief executive officers (CEOs) and/or board members of 58 Canadian NSOs (RR = 55%) participated in an online survey. Data were collected about brand governance in the organization (8 questions), the interrelationship with stakeholders (4 questions), and the role of social media in brand governance (4 questions).Results and findings: Brand governance is absent in small NSOs, and in early stages of application by larger NSOs. NSOs deal with their brand primarily internally, with no operational involvement of stakeholders, missing opportunities for possible knowledge transfer and co-creation to help NSOs govern their brand. Social media is a cost-efficient way to brand the organization, but a lack of control and consistency indicates a need for brand governance related to social media.Implications: NSOs would benefit from actively involving stakeholders to co-create and strengthen their brand. Social media offers opportunities for branding, but governance regulations should help overcome major challenges. Future research should include interviews with NSOs’ decision-makers to further understand how NSOs can engage more meaningfully with stakeholders and social media to strengthen their brand governance.
An Online Virtual Learning Environment for Higher Education (2011)

This paper describes a novel online virtual learning classroom environment focused for higher education. Students can login to this virtual world in the form of their avatars and follow lectures and laboratories in a collaborative manner. To prove the feasibility of the system, the lecture material from a 2nd year BSc degree called '3D Graphics Programming' module was ported into the online virtual learning environment. Initial evaluation with 20 users showed that overall the online virtual learning environment is enjoyable and has the potential to be used for the development and delivery of distance learning courses and degrees.
A New VLSI Graphics Coprocessor-The Intel 82786 (1986)

Most graphics systems available today suffer from low performance, minimal flecibility, or high cost and high component count. Intel carefully looked at these problems and designed the 82786 chip to address them. The 82786 combines into a single of supporting today's graphics standards and a powerful display processor that supports windowing in hardware.
Sparse Stochastic Inference for Latent Dirichlet allocation (2012)

We present a hybrid algorithm for Bayesian topic models that combines the efficiency of sparse Gibbs sampling with the scalability of online stochastic inference. We used our algorithm to analyze a corpus of 1.2 million books (33 billion words) with thousands of topics. Our approach reduces the bias of variational inference and generalizes to many Bayesian hidden-variable models.
CONJUNCT POLYMERIZATION—THE INFLUENCE OF TEMPERATURE, CONCENTRATION, AND QUANTITY OF SULFURIC ACID ON POLYMERIZATION OF OLEFINS (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCONJUNCT POLYMERIZATION—THE INFLUENCE OF TEMPERATURE, CONCENTRATION, AND QUANTITY OF SULFURIC ACID ON POLYMERIZATION OF OLEFINSV. N. IPATIEFF and HERMAN PINESCite this: J. Org. Chem. 1936, 01, 5, 464–489Publication Date (Print):November 1, 1936Publication History Published online1 May 2002Published inissue 1 November 1936https://pubs.acs.org/doi/10.1021/jo01234a003https://doi.org/10.1021/jo01234a003research-articleACS PublicationsRequest reuse permissionsArticle Views331Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fibroblast Hepatocyte Growth Factor Promotes Invasion of Human Mammary Ductal Carcinoma <i>In situ</i> (2009)

Stromal-derived hepatocyte growth factor (HGF) acting through its specific proto-oncogene receptor c-Met has been suggested to play a paracrine role in the regulation of tumor cell migration and invasion. The transition from preinvasive ductal carcinoma in situ (DCIS) to invasive breast carcinoma is marked by infiltration of stromal fibroblasts and the loss of basement membrane. We hypothesized that HGF produced by the infiltrating fibroblasts may alter proteolytic pathways in DCIS cells, and, to study this hypothesis, established three-dimensional reconstituted basement membrane overlay cocultures with two human DCIS cell lines, MCF10.DCIS and SUM102. Both cell lines formed large dysplastic structures in three-dimensional cultures that resembled DCIS in vivo and occasionally developed invasive outgrowths. In coculture with HGF-secreting mammary fibroblasts, the percentage of DCIS structures with invasive outgrowths was increased. Activation of c-Met with conditioned medium from HGF-secreting fibroblasts or with recombinant HGF increased the percentage of DCIS structures with invasive outgrowths, their degradation of collagen IV, and their secretion of urokinase-type plasminogen activator and its receptor. In agreement with the in vitro findings, coinjection with HGF-secreting fibroblasts increased invasiveness of MCF10.DCIS xenografts in severe combined immunodeficient mice. Our study shows that paracrine HGF/c-Met signaling between fibroblasts and preinvasive DCIS cells enhances the transition to invasive carcinomas and suggests that three-dimensional cocultures are appropriate models for testing therapeutics that target tumor microenvironment-enhanced invasiveness.
Attractiveness of Facial Averageness and Symmetry in Non-Western Cultures: In Search of Biologically Based Standards of Beauty (2001)

Averageness and symmetry are attractive in Western faces and are good candidates for biologically based standards of beauty. A hallmark of such standards is that they are shared across cultures. We examined whether facial averageness and symmetry are attractive in non-Western cultures. Increasing the averageness of individual faces, by warping those faces towards an averaged composite of the same race and sex, increased the attractiveness of both Chinese (experiment 1) and Japanese (experiment 2) faces, for Chinese and Japanese participants, respectively. Decreasing averageness by moving the faces away from an average shape decreased attractiveness. We also manipulated the symmetry of Japanese faces by blending each original face with its mirror image to create perfectly symmetric versions. Japanese raters preferred the perfectly symmetric versions to the original faces (experiment 2). These findings show that preferences for facial averageness and symmetry are not restricted to Western cultures, consistent with the view that they are biologically based. Interestingly, it made little difference whether averageness was manipulated by using own-race or other-race averaged composites and there was no preference for own-race averaged composites over other-race or mixed-race composites (experiment 1). We discuss the implications of these results for understanding what makes average faces attractive. We also discuss some limitations of our studies, and consider other lines of converging evidence that may help determine whether preferences for average and symmetric faces are biologically based.
Notch Inhibitors as a New Tool in the War on Cancer: A Pathway to Watch (2009)

Notch was first recognized as an important developmental pathway in Drosophila in the first half of the 20th century. Many decades later, this pathway has been found to play central roles in humans in stem cell maintenance, cell fate decisions, and in cancer as well. Notch family members are being revealed as oncogenes in an ever-increasing number of cancers. Though significant progress has been made in dissecting the complex workings of this signaling pathway, there are very limited options available for Notch inhibitors. However, the pioneering class of Notch inhibitors is already in clinical trials for two cancer types. This review will address the current state-of-the-art, agents in the pipeline, and potential strategies for future Notch inhibitors. Successful development of Notch inhibitors in the clinic holds great promise as a new anti-cancer strategy.
Level set-based bimodal segmentation with stationary global minimum (2006)

In this paper, we propose a new level set-based partial differential equation (PDE) for the purpose of bimodal segmentation. The PDE is derived from an energy functional which is a modified version of the fitting term of the Chan-Vese model. The energy functional is designed to obtain a stationary global minimum, i.e., the level set function which evolves by the Euler-Lagrange equation of the energy functional has a unique convergence state. The existence of a global minimum makes the algorithm invariant to the initialization of the level set function, whereas the existence of a convergence state makes it possible to set a termination criterion on the algorithm. Furthermore, since the level set function converges to one of the two fixed values which are determined by the amount of the shifting of the Heaviside functions, an initialization of the level set function close to those values can result in a fast convergence.
Demonstration of IgE Antibodies to Nucleic Acid Antigens in Patients with Sle (1990)

Using a combination of avidin-biotin microELISA and solid phase radioimmunoassay, we examined sera from 23 patients with systemic lupus erythematosus (SLE), two patients with established sensitivity to ingested shrimp, and 15 healthy normal subjects. In addition to IgG antibodies, varying amounts of IgE antibodies specific for native DNA (nDNA), denatured or single-stranded DNA (dnDNA), RNA, and tRNA were demonstrable in the sera of SLE patients, but not in the sera of normal subjects. A comparison of the specificity of nucleic acid-specific IgE antibodies present in the sera of shrimp-sensitive patients with those present in the sera of seven SLE patients revealed that the IgE antibodies in the sera of shrimp-sensitive patients specifically recognized shrimp tRNA but not yeast tRNA, calf thymus RNA, or calf thymus DNA, while those present in the sera of patients with SLE recognized all these nucleic acid antigens. The IgE antibodies directed against nDNA, dnDNA, RNA, and tRNA may mediate mast cell and basophil degranulation and thus contribute both to immediate-type hypersensitivity phenomena including hives seen in patients with SLE and to the localization of IgE-nucleic acid complexes in target tissues.
Effect of Circumferential Grooves on the Aerodynamic Performance of an Axial Single-Stage Transonic Compressor (2007)

This paper reports on experimental and numerical investigations on circumferential grooves in an axial single-stage transonic compressor. Total pressure ratio and efficiency speedlines were taken at design speed and three off-design conditions. The experiments comprise four different configurations with deep and shallow grooves and variable coverage of the projected rotor axial chord. All casing treatments proved to have a beneficial effect on stall range while maintaining high levels of efficiency, even at off-design operation. Deep grooves extending almost to the trailing edge showed the biggest potential: the mass flow at stall inception for design speed could be strongly reduced, and the operating range could be enlarged by 56.1%. When three shallow grooves were applied to the compressor, the stage efficiency at design speed was shifted to slightly higher values. A possible explanation could be a favorable change in stator aerodynamics due to the reduction of corner separation. For a closer look into the physical effects of grooves on the tip leakage flow, a rotor-only CFD analysis has been carried out using a steady state calculation. A multi-block grid with approximately 1.2 million nodes was used. The numerical simulations reveal strong effects of circumferential grooves on the rotor flow field at tip. Mach-number contours, axial velocity distributions and particle traces for the smooth casing and six deep grooves are presented at stall mass flow. Compared to the smooth wall case, the treated casing significantly reduces blockage in the tip area and weakens the roll-up of the core vortex. These mechanisms prevent an early spillage of low momentum fluid into the adjacent blade passage and delay the onset of rotating stall.
Antigenic characteristics and serological identification of 10 black-pigmented Bacteroides species (1986)

Strains of 10 black-pigmented Bacteroides species were serologically characterized using absorbed and unabsorbed rabbit antisera. An agglutination test using intact cells or heated cells (100 degrees C for 60 min) from each species and unabsorbed antisera revealed only homologous reactions with little or no reactivity in heterologous assays. Immunodiffusion tests using sonicated antigen demonstrated that Bacteroides gingivalis, B. endodontalis, B. asaccharolyticus, B. macacae, and B. levii are antigenically distinct. Strains of B. gingivalis, B. endodontalis, and B. asaccharolyticus were also clearly identified by the indirect immunofluorescent antibody method. B. intermedius, B. corporis, B. loescheii, B. melaninogenicus, and B. denticola possessed common antigens; however, species-specific antigens detectable with immunoabsorbed antisera were also demonstrated. B. intermedius strains isolated from the human oral cavity included at least two serogroups. In each black-pigmented Bacteroides species, lipopolysaccharide constituted one of the species-specific antigens.