gebhart/patrepeval huggingface dataset:
CHIR-265 is a potent selective inhibitor of c-Raf/B-Raf/mutB-Raf that effectively inhibits proliferation and survival of cancer cell lines with Ras/Raf pathway mutations (2006)

4855 The Ras/Raf/MEK/ERK signal transduction cascade is a very compelling pathway to disrupt in several cancer types because of its role as a vital mediator of cell proliferation, survival and other aspects of cellular behavior that contribute to the transformed phenotype. The Raf serine/threonine kinases are central to this signaling pathway and the fact that activating mutations often occur in B-Raf (melanoma, low-grade ovarian, papillary thyroid) underscores the importance of this target in cancer. CHIR-265 is an orally-bioavailable, selective, potent inhibitor of C-Raf, wild type B-Raf and mutant (V600E) B-Raf (IC 50 range from 3 to 60 nM). Concentrations of CHIR-265 that effectively block phosphorylation of Raf’s downstream substrates MEK and ERK in cells, also kill melanoma and colorectal cancer cell lines harboring B-Raf mutations independent of PTEN mutation status. EC 50 values for p-ERK inhibition range from 140 to 300 nM in SK-MEL-28 (human melanoma, mut B-Raf V600E , PTEN +, P53 -), Malme-3M (human melanoma, mut B-Raf V600E , PTEN +, P53 wt), and A375M (human melanoma, mut B-Raf V600E , PTEN -, P53 wt). Raf kinase inhibition by CHIR-265 in mutant B-Raf melanoma cell lines causes cell cycle arrest and induces apoptosis, mimicking the effect of Raf RNAi in these cells. Additionally, CHIR-265 inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2). Potent inhibition of phosphorylation of VEGFR-2 and proliferation of VEGF-stimulated hMVEC (EC 50 = 30 &20 nM) indicate that CHIR-265 is a potent inhibitor of both Raf and the pro-angiogenic kinase, VEGFR. Consistent with its in vitro activity, CHIR-265 causes tumor regression and dose-dependent tumor growth inhibition in B-Raf-driven human melanoma xenograft model. The demonstration that CHIR-265 is very effective ( in vitro and in vivo ) in inhibiting Raf enzymes, key kinases for cancer cell growth and survival, suggests that this compound is an excellent clinical candidate to treat Raf driven cancer such as malignant melanoma.
The Gasoline Spray Characteristics of Tapered Nozzle for a Swirl Injector (2007)

The swirl spray for direct-injection spark-ignition (DISI) engines was investigated using a nozzle whose exit surface shape was cut with a certain tapered angle. The reason for the change in spray's characteristics at various tapered angles was explained by the data correlating the taper and flow angles. The spray tended to shift its characteristics from the symmetric to asymmetric when the tapered angle was increased; furthermore, the spray penetration and spray cone angle were also increased. When the tapered angle was greater than the minus flow angle, an opened hollow cone spray was formed because of the fuel impingement against the tapered surface area of the nozzle exit. This behavior indicates that the reduction in the air pressure difference between the inner and outer spray of the spray can be achieved. This behavior also promises the potential use of the tapered nozzle for the case where the independence of the spray performance from atmospheric pressure and fuel temperature is desired.
Aerosol-assisted delivery of precursors for chemical vapour deposition: expanding the scope of CVD for materials fabrication (2013)

The production of thin films of materials has become the attention of a great deal of research throughout academia and industry worldwide owing to the array of applications which utilise them, including electronic devices, gas sensors, solar cells, window coatings and catalytic systems. Whilst a number of deposition techniques are in common use, chemical vapour deposition (CVD) is an attractive process for the production of a wide range of materials due to the control it offers over film composition, coverage and uniformity, even on large scales. Conventional CVD processes can be limited, however, by the need for suitably volatile precursors. Aerosol-assisted (AA)CVD is a solution-based process which relies on the solubility of the precursor, rather than its volatility and thus vastly extends the range of potentially applicable precursors. In addition, AACVD offers extra means to control film morphology and concurrently the properties of the deposited materials. In this perspective we discuss the AACVD process, the influence of deposition conditions on film characteristics and a number of materials and applications to which AACVD has been found beneficial.
Solving finite element equations on concurrent computers (1987)

This paper discusses the development of a concurrent algorithm for the solution of systems of equations arising in finite element applications. The approach is based on a hybrid of direct elimination method and preconditioned conjugate iteration. Two different preconditioners are used; diagonal scaling and a concurrent implementation of incomplete LU factorization. First, an automatic procedure is used to partition the finite element mesh into sub-structures. The particular mesh partition is chosen to minimize an estimate of the cost for evaluating the solution using this algorithm on a concurrent computer. These procedures are implemented in a finite element program on the JPL/CalTech MARK III hypercube computer. An overview of the structure of this program is presented. The performance of the solution method is demonstrated with the aid of a number of numerical test runs, and its advantages for concurrent implementations are discussed. Efficiency and speed-up factors over sequential machines for the numerical examples are highlighted.
LACK OF REVERSAL WITH VERAPAMIL OF DRUG RESISTANCE IN MULTIPLE MYELOMA (1990)

The vinca alkaloids vincristin sulphate and vindesine are useful drugs in the treatment of multiple myeloma in combination with melphalan, cyclosphosphamide and prednisone. llnfortunately sooner or later resistant clones develop, possibly due to selection of intrinsic less sensitive tumour cells already present at initiation of treatment, or emerging during treatment (Skovsgaard et al. 1984; Kyle,
Treatment of Inoperable Cancer by Intra-Arterial Administration of Mechlorethamine (1957)

This report describes results obtained from the fractionated, regional intra-arterial administration of mechlorethamine hydrochloride (methyl-bis[β-chlorethyl]amine hydrochloride; HN 2 ) in a series of 60 patients with inoperable cancer. In each instance, oxytetracycline (Terramycin) was given concomitantly with the mechlorethamine. The effects of oxytetracycline were investigated in view of the observations of Barberio, who noted that the simultaneous administration of chlortetracycline (Aureomycin) and mechlorethamine seemed to have a greater adverse influence upon the cancer than mechlorethamine alone. Methods and Procedure The femoral artery is cannulated under direct vision, an incision being made inferior to Poupart's ligament, parallel to the course of the artery. After the artery has been mobilized, a small polyethylene catheter is inserted through it into the aorta. If the treatment is for cancer of the pelvis, the polyethylene tube is inserted a few inches above the bifurcation of the aorta. If efforts are being made to alleviate hepatic or
Design of high thermal conductivity insulation adhesive (H-class) for low voltage motor (2016)

In order to reduce the winding temperature furthest, we adopted the method of adding micron-grade filler to ET-90 base resin, and prepared three kinds of modified high-thermal conductivity adhesive specimens (H-Class). At the same time, four kinds of performance tests (water-absorption, adhesive-strength, breakdown-strength, thermal conductivity) had been done for them, the test results showed specimen III adhesive had a highest thermal-conductivity (0.31 W/m<;/sup>.<;/sup>K), and finally specimen III adhesive was selected for testing. A new insulating system was developed, it consists of specimen III adhesive, self-made slot wedges and insulating paper. We applied the new insulating system to motors, and observed the changing results of winding temperature and no load loss. The results showed that the winding temperature could decrease by about 7 K from before, the no-load loss also has a decrease correspondingly. In the meantime, the motor efficiency increases by 0.7% compared to the original state and improves to nearly 86.6%. Thus, this research indicates that this new high thermal-conductivity adhesive (H-Class) could lower temperature in the windings and improve the motor efficiency simultaneously, it is of great significance in practical application.
Fluorinated analogs of leucine, methionine, and valine (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorinated analogs of leucine, methionine, and valineJoseph Lazar and William A. SheppardCite this: J. Med. Chem. 1968, 11, 1, 138–140Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://pubs.acs.org/doi/10.1021/jm00307a030https://doi.org/10.1021/jm00307a030research-articleACS PublicationsRequest reuse permissionsArticle Views244Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Indoor Location System Based on Discriminant-Adaptive Neural Network in IEEE 802.11 Environments (2008)

This brief paper presents a novel localization algorithm, named discriminant-adaptive neural network (DANN), which takes the received signal strength (RSS) from the access points (APs) as inputs to infer the client position in the wireless local area network (LAN) environment. We extract the useful information into discriminative components (DCs) for network learning. The nonlinear relationship between RSS and the position is then accurately constructed by incrementally inserting the DCs and recursively updating the weightings in the network until no further improvement is required. Our localization system is developed in a real-world wireless LAN WLAN environment, where the realistic RSS measurement is collected. We implement the traditional approaches on the same test bed, including weighted kappa-nearest neighbor (WKNN), maximum likelihood (ML), and multilayer perceptron (MLP), and compare the results. The experimental results indicate that the proposed algorithm is much higher in accuracy compared with other examined techniques. The improvement can be attributed to that only the useful information is efficiently extracted for positioning while the redundant information is regarded as noise and discarded. Finally, the analysis shows that our network intelligently accomplishes learning while the inserted DCs provide sufficient information.
Oxidation of Polyethylene: A Comparison of Plasma and Ultraviolet Ozone Processing Techniques (2009)

Abstract : Plasma and ultraviolet (UV) ozone treatments were compared as methods to functionalize ultrahigh molecular weight polyethylene films in order to make them more compatible with materials or reactive for subsequent surface chemistry. Oxidation states and atomic compositions were determined using x-ray photoelectron spectroscopy, while surface energy and bond stability were probed with contact angle goniometry. Both modification techniques increased the surface energy of the polymer, and the bonds formed were found to be stable over a period of 30 days. Plasma treatment times were much shorter than UV ozone; thus, plasma was determined to be a more efficient surface modification technique.
Scaling Egocentric Vision: The EPIC-KITCHENS Dataset (2018)

First-person vision is gaining interest as it offers a unique viewpoint on people's interaction with objects, their attention, and even intention. However, progress in this challenging domain has been relatively slow due to the lack of sufficiently large datasets. In this paper, we introduce EPIC-KITCHENS, a large-scale egocentric video benchmark recorded by 32 participants in their native kitchen environments. Our videos depict nonscripted daily activities: we simply asked each participant to start recording every time they entered their kitchen. Recording took place in 4 cities (in North America and Europe) by participants belonging to 10 different nationalities, resulting in highly diverse cooking styles. Our dataset features 55 hours of video consisting of 11.5M frames, which we densely labeled for a total of 39.6K action segments and 454.3K object bounding boxes. Our annotation is unique in that we had the participants narrate their own videos (after recording), thus reflecting true intention, and we crowd-sourced ground-truths based on these. We describe our object, action and anticipation challenges, and evaluate several baselines over two test splits, seen and unseen kitchens. Dataset and Project page: http://epic-kitchens.github.io
Pectinolytic activity of <i>Saccharomyces fragilis</i> cultured in controlled environments (1978)

Abstract Seven of 30 yeast stock cultures, covering nine genera, and 13 of 39 yeasts isolated from grapes gave positive reactions when screened for pectinolytic activity on pectin gel plates. The seven stock cultures covered six species and four genera. Only one of the yeasts, Saccharomyces fragilis Y49, excreted discernible pectinolytic activity into the fluid of shake flask cultures; the activity was partially constitutive and was repressed by high oxygen tensions.
The Cyclooxygenase-2 Inhibitors: Safety and Effectiveness (1999)

Specific COX-2 inhibitors offer promising benefits over older NSAIDs with regard to gastrointestinal safety while maintaining analgesic and antiinflammatory efficacy. Further study is required to determine long-term efficacy and safety in clinical use.
Enzyme immunofiltration staining assay for immediate diagnosis of herpes simplex virus and varicella-zoster virus directly from clinical specimens (1987)

A simple, sensitive, 30-min assay for the detection of herpes simplex virus (HSV) and varicella-zoster virus (VZV) antigens in clinical specimens is described. The assay utilizes a filter manifold, biotinylated monoclonal antibodies, streptavidin-horseradish peroxidase conjugate, and the substrate aminoethylcarbazole. The method stains infected cells and cell debris a bright red and is easily interpreted with a dissecting microscope. Reconstruction experiments indicated that as few as two virus-infected cells per swab could be detected. This was equivalent to an infectivity titer of 29 to 160 50% tissue culture infective doses per infected cell and 250 times more sensitive than an enzyme immunofiltration assay which detects a soluble reaction product. Clinical swab specimens collected from ocular, oral, skin, and genital lesions were cultured for virus, and the remaining cell debris was immobilized on glass fiber filters and stained for the presence of virus antigens. Of 71 HSV culture-positive specimens, 66 (93%) were positive for HSV antigens. All of nine VZV culture-positive specimens were positive for VZV antigens. Of 98 culture-negative specimens, 7 were positive for either HSV (n = 3) or VZV (n = 4) antigens.
Seasonal dynamics of stream networks in shallow groundwater systems: A simple analytical approach (1998)

Surface water and groundwater are normally closely connected in areas with shallow aquifer systems. Stream systems can thus be considered as the outcrops of associated groundwater flows in areas with a shallow groundwater table and a previous subsurface where almost all rainfall surplus infiltrates. The stream network must have the capacity to release the seasonally dependent precipitation surplus through the continuum of ground and surface waters. A stream network therefore consists of a hierarchical system of discharge-contributing branches of different order and incision depth, that contracts and expands with the seasonal fluctuation in recharge and water table depth. Coupling the mathematical expressions for groundwater drainage and stream flow enables development of a conjunctive model which relates stream density and channel size to the seasonal rainfall character for given geological and geomorphological conditions. This model further allows for assessment of a drainage network response to a changing environment.
A 100 MHz pipelined CMOS comparator for flash A/D conversion (2003)

A description is given of the design of a VLSI-compatible CMOS comparator wherein voltage comparisons are accomplished directly by means of regenerative sensing. Input sampling, offset correction and common-mode cancellation have been incorporated into a pipelined cascade of regenerative sense amplifiers. Integrated in a standard 2- mu m CMOS technology, the comparator operates at a maximum sampling rate of over 100 MHz, while dissipating only 3.6 mW of power from a single +5-V supply.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Computer Aided Train Dispatching: Decision Support Through Optimization (1983)

A mini-computer based information system with on-line optimal route planning capability was developed to assist dispatchers on the complex northern portion of Southern Railway's Alabama Division. The routing plan is revised automatically as conditions change. Since implementation in September 1980, train delay has been more than 15 percent lower, reflecting annual savings of $316,000. The dispatching support system is now being expanded to all other Southern Railway operating divisions with $3,000,000 annual savings expected from reduced train delay.
High performance micromachined GaN on Si HEMT with backside diamondlke-carbon/titanium heat dissipation layer (2014)

In this work, a thermally stable air-bridged matrix (ABM) AlGaN/GaN high electron mobility transistor (HEMT) with micromachined diamondlke carbon (DLC)/Titanium thermal-distributed layers was demonstrated. After removing the Si substrate beneath the HEMT, the DLC/Ti heat dissipation layers were deposited on the backside of the HEMT, and a significant breakdown voltage improvement was observed. The drain and source terminals were arranged as the matrix type. Compared to the traditional multi-fingers HEMT, the current density was doubled. In addition, the self-heating phenomenon of power cell was also suppressed by the backside DLC/Ti heat dissipation layer.
Characterization of UWB video transmission channels in reflective environment between a truck and its trailer (2009)

For large vehicle manoeuvring-aid based on a Birdpsilas-Eye-View, the possibilities of a wireless UWB video transmission between vehicles and their trailers are investigated. Transmission channels for point-to-point transmission in such transmission scenarios are characterized with respect to changing geometrical conditions of the very reflective environment. Measurements and theoretical investigations lead to a specification of limits for the dynamic range and the data rate.
Sugar‐coated <i>Daphnia</i>: A preservation technique for Cladocera1 (1973)

Carapace distortion and loss of eggs by preserved Daphnia was prevented by adding 40 g liter −1 sucrose to 4% Formalin.
The Double-Density Dual-Tree DWT (2004)

This paper introduces the double-density dual-tree discrete wavelet transform (DWT), which is a DWT that combines the double-density DWT and the dual-tree DWT, each of which has its own characteristics and advantages. The transform corresponds to a new family of dyadic wavelet tight frames based on two scaling functions and four distinct wavelets. One pair of the four wavelets are designed to be offset from the other pair of wavelets so that the integer translates of one wavelet pair fall midway between the integer translates of the other pair. Simultaneously, one pair of wavelets are designed to be approximate Hilbert transforms of the other pair of wavelets so that two complex (approximately analytic) wavelets can be formed. Therefore, they can be used to implement complex and directional wavelet transforms. The paper develops a design procedure to obtain finite impulse response (FIR) filters that satisfy the numerous constraints imposed. This design procedure employs a fractional-delay allpass filter, spectral factorization, and filterbank completion. The solutions have vanishing moments, compact support, a high degree of smoothness, and are nearly shift-invariant.
Fertilizing with Biosolids (2022)

Revised June 2007. A more recent revision exists. Please check for up-to-date information in the OSU Extension Service Catalog: http://extension.oregonstate.edu/catalog
Combining Abilities and Relative Dominance among Maize Inbreds for Resistance to Earworm Injury<sup>1</sup> (1969)

General combining ability effects for corn earworm, Heliothis zea (Boddie), resistance were highly significant and accounted for approximately two‐thirds of the genetic variability measured in two sets of diallel crosses among sweet corn, Zea mays (L.)> inbreds. Specific combining ability estimates were generally low, though significant in one case. Highly significant genotype‐environment mean squares were attributed to the interaction of general combining ability with location and years. The relative importance of location effects was essentially equivalent to those for years. Trends among constant parent regression coefficients were essentially absent, suggesting a low level of dominance for resistance to earworm injury. Dominance estimates for individual inbreds and average estimates as obtained from variance component ratios for diallel sets were also in the partial dominance range. Estimates of heritability for selection of half‐sib families were .340 and .398 for the nine‐line and 12‐line sets, respectively. Although heritabilities of this size should make reasonable selection gains possible, culling F 1 's with large noncomplementing specific combining ability effects from selected half‐sib families of high general combining ability would further enhance potential selection gains.
An algebraic approach to feature interactions (1992)

The various approaches proposed to provide communication between CAD systems and process planning systems share the major problem that, due to geometric interactions among features, there may be several equally valid sets of manufacturable features describing the same part, and different sets of features may differ in their manufacturability. Thus, to produce a good process plan-or, in some cases, any plan at ll-it may be necessary to interpret the part as a different set of features than the one initially obtained from the CAD model. This is addressed using an algebra of features. Given a set of features describing a machinable part, other equally valid interpretations of the part can be produced by performing operations in the algebra. This will enable automated process planning systems to examine these interpretations in order to see which one is most appropriate for use in manufacturing. The feature algebra has been implemented for a restricted domain and integrated with the Protosolid solid modeling system and the EFHA process planning system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>