gebhart/patrepeval huggingface dataset:
Physiologic Specialization of <i>Puccinia triticina</i> in Canada in 1998 (2001)

In 1998, leaf rust of wheat (Triticum aestivum), caused by Puccinia triticina, was widespread throughout the prairies of western Canada. Warm summer temperatures with frequent dew periods favored spread of the disease in wheat fields in Manitoba and Saskatchewan. The Canada Prairie Spring wheat cultivars (AC Vista, AC Foremost, AC Crystal) were susceptible to leaf rust, while the bread wheat cultivars with leaf rust resistance genes Lr16 and Lr13 or Lr34 (AC Majestic, AC Domain, AC Barrie) had high to moderate levels of leaf rust infections. Bread wheat cultivars AC Cora, AC Minto, Pasqua, and McKenzie had trace to low levels of leaf rust infection. Thirty-four virulence phenotypes of P. triticina were identified on 16 Thatcher lines, which are near-isogenic for leaf rust resistance genes. Phenotypes with virulence to Lr16 increased to 25% of isolates in Manitoba and Saskatchewan in 1998. Forty-three isolates were also tested for virulence to plants with the adult plant resistance genes Lr12, Lr13, Lr34, and Lr13,34. Most isolates had virulence to Lr12 and Lr13. All isolates had lower infection type on adult plants with Lr34 compared with Thatcher.
Substrates for the Epitaxial Growth of MCT (2010)

This chapter contains sections titled: Introduction Substrate orientation CZT substrates Si-based substrates Other substrates Summary and conclusions References
Dynamics of Blood Components and Peritoneal Fluid during Treatment of Murine <i>E. coli</i> Sepsis with β‐1,3‐D‐polyglucose Derivatives (1990)

The influences of pretreatment with beta-1,3-D-polyglucose derivatives on levels of cytokines and arachidonic acid metabolites in body fluids in experimental peritonitis in mice are reported. Peritonitis was induced by an intraperitoneal injection of 10(8) live Escherichia coli. Pretreated animals survived the infection, untreated animals died about 12 h after inoculation with E. coli. Levels of IL-1 in plasma and peritoneal fluid, measured by cytotoxicity assay of the HT-2 cell line, increased significantly during the first 48 h after intraperitoneal treatment with beta-1,3-D-polyglucose-derivatized microbeads (GDM) or soluble, aminated beta-1,3-D-polyglucose (AG). After subsequent challenge with E. coli, the levels of IL-1 were significantly lower than in untreated animals. There was no increase in levels of TNF after treatment with GDM or AG, measured by cytotoxicity assay of the WEHI clone 13 cell line. After challenge with E. coli, TNF in plasma and peritoneal fluid was significantly lower compared with untreated animals. Both PGE2 and LTB4, measured by radioimmunoassay kits, were increased in peritoneal fluid after treatment with GDM and AG. After challenge with E. coli, PGE2 and LTB4 in peritoneal fluid increased to about half the concentration of infected control animals. Intraperitoneal injection of indomethacin to pretreated animals resulted in increased levels of IL-1 and TNF and decreased levels of PGE2 following challenge with E. coli. The levels of IL-1 and TNF remained elevated until the animals died after about 12 h. These studies demonstrate that the raised levels of arachidonic acid metabolites after pretreatment with GDM or AG seem to inhibit the otherwise lethal elevation of IL-1 and TNF in body fluids which is seen in untreated animals.
Accelerating tomato fruit maturity with Ethrel (1969)

THE NEW GROWTH REGULATOR, Ethrel (2-chloroethyl phosphonic acid), is similar in action to ethylene in its effects on various plant processes: it accelerates post-harvest ripening of tomato, banana, and honeydew melon fruits; it induces flowering in pineapple plants; it causes female flower differentiation in cucumber plants; and it acts as a thinning agent by accelerating abscission of flowers and young fruit in certain trees and by loosening fruit at harvest to aid mechanical harvesting. These experiments were initiated to examine the effects of Ethrel on growth and maturation of tomato fruit on the vine under both greenhouse and field conditions.
Reduction of Power and Test Time by Removing Cluster of Don&#146;t-Care from Test Data Set (2005)

Reduction of power dissipation and test time is accomplished by forming two clusters of don't-care inside an input and a response test cube, respectively. These clusters are out of the scan operation.
Targeting Tumor Angiogenesis with Histone Deacetylase Inhibitors: the Hydroxamic Acid Derivative LBH589 (2006)

This study provides evidence that LBH589 induces a wide range of effects on endothelial cells that lead to inhibition of tumor angiogenesis. These results support the role of HDAC inhibitors as a therapeutic strategy to target both the tumor and endothelial compartment and warrant the clinical development of these agents in combination with angiogenesis inhibitors.
[Prevalence and incidence of NSAID-induced gastrointestinal ulcers and bleeding]. (2007)

Helicobacter pylori infection and non-steroidal anti-inflammatory drugs (NSAID) have been accepted as major causes of upper gastrointestinal (GI) ulcers and bleeding. As patients with Helicobacter pylori infection have decreased, upper GI disorders related to NSAID have been relatively increasing. Among patients taking low-dose aspirin, the prevalence of upper GI ulcers is 10-40% and aspirin increases the risk of upper GI bleeding up to 2-fold. Among patients taking nonaspirin NSAID, the prevalence of upper GI ulcers is around 20% and nonaspirin NSAID increases the risk of upper GI bleeding up to 4- to 6-fold. Since the prevalence of GI disorders related to NSAID is very high, endoscopic examination might be considered to monitor GI lesions for patients taking NSAID.
Self-recoverable antenna arrays (2012)

An approach is proposed for a self-recovery algorithm (SRA) to be embedded in an autonomous and reprogrammable controller device that would be used to monitor a system, sense failures of the system components and find a solution to recover the functionality of the system as much as possible. The approach presented here is on the scenario of self-recoverable antenna arrays, perceived as one of the vital interests in today's world of ubiquitous communication. The SRA is presented when run on a desktop computer and an field programmable gate arrays (FPGA) chip, to show the effectiveness of the approach on a few examples.
The effect of in vitro human immunodeficiency virus infection on dendritic-cell differentiation and function (1996)

CD1a+ dendritic cells (DC) differentiate from a major population of nonadherent CD13(hi)lin-cells that appear when human cord blood CD34+ hematopoietic progenitor cells are cultured with stem-cell factor, granulocyte/macrophage (MA) colony-stimulating factor, and tumor necrosis factor-alpha (TNF-alpha) for 5 days. CD13hilin- cells, which also comprise MA and granulocyte precursors, are CD4+ and can thus be targets of human immunodeficiency virus (HIV). Low replication was noted when these day 5 cells were infected with lymphotropic HIV-1LA1 (p24: < or = 4 ng/mL on day 8 postinfection [PI]), while high virus production occurred with MA-tropic HIV-1Ba-L, HIV-1Ada, or HIV-1-m-n. (p24: 50 to > or = 1,000 ng/mL). Strong cytopathicity (CPE) was then observed in nonadherent cells as in adherent MA. However, FACS analysis on day 7 PI showed that HIV did not affect differentiation of DC that survived CPE: apart from CD4 downmodulation related to HIV production, overall expression of CD40, CD80, and CD86 costimulatory molecules, and of HLA-DR, was unchanged relative to controls. At that time, the capacity of DC from HIV-infected cultures to stimulate the mixed leukocyte reaction was only altered less than 10-fold. Immunocytochemistry on day 7 PI showed that most HIV-infected cells were included in syncytia that were stained by anti-CD1a, anti-S100, and anti-CD14 antibodies, indicating that syncytia consisted of DC and cells of the MA lineage. Polymerase chain reaction analysis of FACS- sorted CD1a+ cells confirmed that they harbored then HIV DNA. Viral DNA was also detected in CD1a+ DC from noninfected cultures that had been exposed to HIV only after sorting. Therefore, we examined whether in infected cultures DC precursors were infected at the onset or if virus spread later from other infected cells to differentiated DC. This was answered by showing that, 24 hours postexposure to HIV, viral DNA was preferentially detected in day 5 sorted CD13hilin-versus CD13hilin- cells, and that it was found in the CD1a+ progeny of CD13(hi)lin-cells 48 hours later. In addition, HIV replication did not affect myeloid clonogenic progenitors in day 0 to day 7 PI cultures, although viral DNA was detected in colony-forming unit-granulocyte/macrophage (CFU-GM)/CFU-M colonies derived from day 3 and 7 PI cultures. Thus, precursors of DC and their progeny are susceptible to HIV in vitro, but, apart from CPE, the effect of virus production on DC differentiation or function is limited.
Protein adsorption onto polyester surfaces: Is there a need for surface activation? (2006)

Surface hydrolysis of polyester scaffolds is a convenient technique suggested to promote protein adsorption for improving cell attachment. We have, therefore, investigated the effect of hydrolysis of polyester surfaces for protein adsorption to clarify the conditions needed. Three polyesters, poly(ethylene terephthalate) (PET), poly(lactic acid) (PLA), and poly(glycolic acid) (PGA), were selected. Adsorption was investigated by X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and quartz crystal microbalance (QCM). Hydrolyzed PET adsorbed significantly more proteins than nonhydrolyzed. Degradable polymers adsorbed at higher rates when the polymers were hydrolyzed prior to adsorption, but the same amount as nonhydrolyzed, suggesting spontaneous hydrolysis during the adsorption. XPS shows that hydrolysis prior to absorption for PET results in a surface nitrogen composition of approximately 14%, similar to pure protein (16%). Nonhydrolyzed PET surfaces showed only approximately 7% nitrogen, indicating protein layers thinner than approximately 10 nm. Adsorption to PLA and PGA shows nitrogen contents of 14-15% in both cases. SEM revealed striking differences in morphology of the protein coating. Hydrolyzed or spontaneously hydrolyzable surfaces display a pronounced fibrous structure while nonhydrolyzed surfaces give smooth structures. In combination, the results show that surface hydrolysis increase adsorption rate, but not the amount of proteins on polyesters that degrades in vivo. Surface treatment of nondegradable polyester increases the total amount of proteins and induces the formation of fibrous protein structures. Post hydrolysis treatment by acetic acid, replacing the counter-ion to a proton, further enhances protein attachment. Finally, cell attachment experiments verifies that protein adsorption increase the cell attachment to polyester surfaces.
Adult Image Detection Method Base-on Skin Color Model and Support (2002)

This paper demonstrates an automatic system to detect adult images based on compute vision and pattern recognition. First, images were filtered by skin color model. Then, the output images are classified by support vector machine. The experiment shows that 87.3% images contain naked people could be filtered accurately.
BEL-1, a Novel Clavulanic Acid-Inhibited Extended-Spectrum β-Lactamase, and the Class 1 Integron In120 in <i>Pseudomonas aeruginosa</i> (2005)

Screening by a double-disk synergy test identified a Pseudomonas aeruginosa isolate that produced a clavulanic acid-inhibited expanded-spectrum beta-lactamase (ESBL). Cloning and sequencing identified a novel ESBL, BEL-1, weakly related to other Ambler class A ESBLs. beta-Lactamase BEL-1 hydrolyzed significantly most expanded-spectrum cephalosporins and aztreonam, and its activity was inhibited by clavulanic acid, tazobactam, cefoxitin, moxalactam, and imipenem. This chromosome-encoded ESBL gene was embedded in a class 1 integron containing three other gene cassettes. In addition, this integron was bracketed by Tn1404 transposon sequences at its right end and by P. aeruginosa-specific sequences at its left end.
The structural consequences of site-directed mutations (1987)

Subtilisin from B. am:z;loliguefaciens has been used as a model system to prote1n engineer altered physicochemical characteristics by site-directed mutagenesis. This method has been successful in altering the enzyme's stability, specificity and activity.
Vector Control of Piezoelectric Transducers and Ultrasonic Actuators (2017)

This paper presents the implementation of a novel vibration amplitude control and resonant frequency tracking for piezoelectric transducers (PTs) and ultrasonic motors (USMs). It is based on a generalization of the vector control method to the PT and the USM, which is explained in the first part. We show that two independent controllers with a similar structure are required: one tracks the resonant frequency and the second controls the amplitude. We then present the implementation into a low-cost digital signal processing controller with a sampling period of 200 μs. Experimental results on a Langevin transducer achieved a time response of 20 ms approximately, and the generality of the method is further demonstrated on a 2-D tactile stimulator at the end of this paper.
In Vitro Selection of RNA Aptamer Specific to Salmonella Typhimurium (2013)

Salmonella is a major foodborne pathogen that causes a variety of human diseases. Development of ligands directly and specifically binding to the Salmonella will be crucial for the rapid detection of, and thus for efficient protection from, the virulent bacteria. In this study, we identified a RNA aptamer-based ligand that can specifically recognize Salmonella Typhimurium through SELEX technology. To this end, we isolated and characterized an RNase-resistant RNA aptamer that bound to the OmpC protein of Salmonella Typhimurium with high specificity and affinity (Kd ~ 20 nM). Of note, the selected aptamer was found to specifically bind to Salmonella Typhimurium, but neither to Gram-positive bacteria (Staphylococcus aureus) nor to other Gram-negative bacteria (Escherichia coli O157:H7). This was evinced by aptamer-immobilized ELISA and aptamer-linked precipitation experiments. This Salmonella species-specific aptamer could be useful as a diagnostic ligand against pathogen-caused foodborne sickness.
Ultra-wide bandwidth Raman amplifiers (2002)

We have discussed the design and noise performance issues for ultra-broadband Raman amplifiers. Superposition may be used to optimise pump wavelengths for flat gain spectra with bandwidths in excess of 100 nm, although numerical simulations are necessary to determine actual pump powers. Shorter wavelength signals suffer greater impairments than those at longer wavelengths due to increased ASE generation as signals approach pump wavelengths, and SRS interactions amongst the signals, and between the pumps.
Localized in vivo hyperpolarization transfer sequences (2011)

In vivo localized and fully adiabatic homonuclear and heteronuclear polarization transfer experiments were designed and performed in the rat brain at 9.4 T after infusion of hyperpolarized sodium [1,2-(13)C(2)] and sodium [1-(13)C] acetate. The method presented herein leads to highly enhanced in vivo detection of short-T(1) (13)C as well as attached protons. This indirect detection scheme allows for probing additional molecular sites in hyperpolarized substrates and their metabolites and can thus lead to improved spectral resolution such as in the case of (13)C-acetate metabolism.
Opsoclonus, Myoclonus, Ataxia, and Encephalopathy in Adults with Cancer (1988)

The clinical and pathological findings in 4 adults with cancer and opsoclonus were compared with those of 15 other patients described elsewhere. The clinical syndrome of paraneoplastic opsoclonus is characterized by the acute onset of opsoclonus and truncal ataxia, often accompanied by encephalopathy, myoclonus and a cerebrospinal fluid pleocytosis. Unlike most other paraneoplastic syndromes, the course is often remitting and relapsing. Neuropathological examination in 3 of our patients showed lymphocytic cuffing of occasional blood vessels throughout the central nervous system, associated with a mild, diffuse proliferation of microglia in 1 patient. Apart from a mild, patchy loss of Purkinje cells in 1 patient, there was no loss of neurons from the cerebellum, brainstem, cerebral hemispheres, or spinal cord. These patients differ from those with the more common paraneoplastic cerebellar degeneration by the predominance of truncal over limb ataxia, the presence of myoclonus, the absence of severe dysarthria, a tendency for remission, and the preservation of Purkinje cells.
Video Image Retrieval Based on Improved SIFT Features (2010)

This paper presents an algorithm based on SIFT features. It calculates key points in the image and extracts the feature of the image by calculating the key points' orientation and modulus of the gradient. The similarity between two images is computed using Euclidean distance. The experiment shows that the feature is invariant to image scaling translation, rotation, and partly invariant to illumination changes and has a certain affine invariance. It is better than the color feature in the video image retrieval.
Automatic Identification of Home Pages on the Web (2005)

The research reported in this paper is the first phase of a larger project on the automatic classification of Web pages by their genres. The long term goal is the incorporation of web page genre into the search process to improve the quality of the search results. In this phase, a neural net classifier was trained to distinguish home pages from non-home pages and to classify those home pages as personal home page, corporate home page or organization home page. Results indicate that the classifier is able to distinguish home pages from non-home pages and within the home page genre it is able to distinguish personal from corporate home pages. Organization home pages, however, were more difficult to distinguish from personal and corporate home pages.
Toward Targeting RNA Structure: Branched Peptides as Cell-Permeable Ligands to TAR RNA (2011)

Rational design of RNA ligands continues to be a formidable challenge, but the potential powerful applications in biology and medicine catapults it to the forefront of chemical research. Indeed, small molecule and macromolecular intervention are attractive approaches, but selectivity and cell permeability can be a hurdle. An alternative strategy is to use molecules of intermediate molecular weight that possess large enough surface area to maximize interaction with the RNA structure but are small enough to be cell-permeable. Herein, we report the discovery of nontoxic and cell-permeable branched peptide (BP) ligands that bind to TAR RNA in the low micromolar range from on-bead high-throughput screening of 4,096 compounds. TAR is a short RNA motif in the 5'-UTR of HIV-1 that is responsible for efficient generation of full RNA transcripts. We demonstrate that BPs are selective for the native TAR RNA structure and that "branching" in peptides provides multivalent interaction, which increases binding affinity to RNA.
Effect of Tetrandrine on Calcium‐Dependent Tumour Necrosis Factor‐α Production in Glia‐Neurone Mixed Cultures (2005)

Tumour necrosis factor-alpha is believed to have a deleterious role in the pathophysiology of brain injury. Tetrandrine has protective effect on neuronal cells, however, the mechanisms involved in its action have not been clearly established. The aim of this study was to investigate the role of tetrandrine on calcium-dependent tumour necrosis factor-alpha production in glia-neurone mixed cultures. Glia-neurone mixed cultures were treated by addition of Ca2+ regulating agents for a period of 6 hr. Tetrandrine or/and TMB-8 were added 30 min. before the stimulation. The supernatant tumour necrosis factor-alpha levels were quantified by enzyme-linked immunosorbent assay. Exposure of lipopolysaccharide 10 and 100 ng/ml caused significant increase in tumour necrosis factor-alpha production respectively, with no alteration in cultures treated with 1 ng/ml lipopolysaccharide. Glia-neurone mixed cultures exhibited a marked elevation in tumour necrosis factor-alpha production after exposure to CaCl2, KCl, thapsigargin, BHQ and norepinephrine in the presence of lipopolysaccharide at 1 ng/ml respectively. Tetrandrine 0.3, 1, and 3 microM concentration-dependently reduced tumour necrosis factor-alpha production evoked by CaCl2 or KCl. Tetrandrine preincubation had no significant effect on the response to Ca2+-ATPase inhibitor thapsigargin or BHQ. Norepinephrine-induced tumour necrosis factor-alpha production was significantly reduced by tetrandrine and almost abolished by combination of tetrandrine and intracellular Ca2+ release inhibitor TMB-8. These results suggested that tetrandrine at a concentration of 0.3, 1, or 3 microM inhibited tumour necrosis factor-alpha production induced by Ca2+ entry in glia-neurone mixed cultures.
The combination of guanethidine 3% and adrenaline 0.5% in 1 eyedrop (GA) in glaucoma treatment. (1979)

During a 7-month period 33 patients (20 with primary open-angle glaucoma and 13 with suspected glaucoma) were treated with guanethidine 3% and adrenaline 0.5% in 1 eyedrop twice daily. The previous therapy was discontinued and the aim of the trial was to treat the patients with GA alone. There was an average decrease in intraocular pressure of 10.8 mmHg or 37.5% for the whole group (including 5 patients with additional therapy). In eyes with an average IOP in a day-curve without medication equal to or higher than 28 mmHg we found a decrease of 44.6% or 14.4 mmHg, and in eyes with an average IOP without medication between 21 and 28 mmHg a decrease of 30.4% or 7.6 mmHg. With GA alone the IOP was 3.3 to 3.9 mmHg lower than on the previous therapy (P less than 0.05); 46% of the eyes without additional therapy had all IOPs lower than 22 mmHg and 74% of the eyes had IOPs lower than 22 mmHg except 1 with a peak lower or equal to 25 mmHg 3 hours after application. This peak 3 hours after application indicates that GA has a biphasic action and was significant at the 0.5% level. Red eyes and slight ptosis were no problem for most patients. Patients found it very convenient to administer GA only twice daily.
Increasing the Open Circuit Voltage of Bulk-Heterojunction Solar Cells by Raising the LUMO Level of the Acceptor (2007)

We report the synthesis, characterization, and electrochemical properties of ten new fullerene derivatives for usage in organic solar cells. The phenyl ring of PCBM was substituted with electron-donating and electron-withdrawing substituents to study their influence on the LUMO level of the parent fullerene. We varied the LUMO level over a range of 86 mV and show a small but significant change of the open circuit voltage upon application in MDMO-PPV:methanofullerene bulk-heterojunction photovoltaic cells. [structure: see text].