gebhart/patrepeval huggingface dataset:
Size-Controlled Synthesis of Porphyrinic Metal–Organic Framework and Functionalization for Targeted Photodynamic Therapy (2016)

The understanding of nanomaterials for targeted cancer therapy is of great importance as physical parameters of nanomaterials have been shown to be strong determinants that can promote cellular responses. However, there have been rare platforms that can vastly tune the core of nanoparticles at a molecular level despite various nanomaterials employed in such studies. Here we show targeted photodynamic therapy (PDT) with Zr(IV)-based porphyrinic metal-organic framework (MOF) nanoparticles. Through a bottom-up approach, the size of MOF nanoparticles was precisely tuned in a broad range with a designed functional motif, built upon selection of building blocks of the MOF. In particular, molecular properties of the porphyrinic linker are maintained in the MOF nanoparticles regardless of their sizes. Therefore, size-dependent cellular uptake and ensuing PDT allowed for screening of the optimal size of MOF nanoparticles for PDT while MOF nanoparticle formulation of the photosensitizer showed better PDT efficacy than that of its small molecule. Additionally, Zr6 clusters in the MOF enabled an active targeting modality through postsynthetic modification, giving even more enhanced PDT efficacy. Together with our finding of size controllability covering a broad range in the nano regime, we envision that MOFs can be a promising nanoplatform by adopting advanced small molecule systems into the tunable framework with room for postsynthetic modification.
Standardized Membrane Pore Size Characterization by Polyethylene Glycol Rejection (2002)

The objective of this research was to provide information toward standardization of a method for determining and describing the pore size distribution of ultrafiltration or nanofiltration membranes. Currently, pore size distribution testing is not standardized, making membrane selection to achieve treatment objectives difficult at best. The method utilized in this work provides a standard testing procedure as well as a pair of descriptors (P90 and the tightness coefficient) that provide needed information about the membrane pore sizes and pore size distribution. The method requires minimal equipment and no specialized knowledge. Determination of both P90 and the tightness coefficient allows direct comparison of mean pore size and pore size distribution of membranes on a standardized basis. The pore size distribution of three membranes was determined under varying solution and pressure conditions by measuring the solute rejection for various sizes of polyethylene glycol molecules in the range of 600 to 35,000 daltons. The method can be replicated and the results are independent of the process variables of pressure and solution characteristics within the region likely to be encountered in drinking water treatment.
A New Approach in CAD System for Designing Shoes (2003)

The flattening of digitized surfaces is still very important in design of thin walled objects such as the airplane wings, parts of car bodies, textile products, and shoe uppers. Especially in shoe industry, the ability of quick respond to changing market needs is essential for successful competition. To give needed flexibility to a shoe designer, special CAD/CAM systems have been developed. Those systems are based on algorithms for surface reconstruction and surface flattening. In this article a fast algorithm for surface reconstruction and surface flattening is presented. Developable stripes are used to approximate a surface. In this way the surface can be flattened fast and without any distortions.
Real-time ECG monitoring and arrhythmia detection using Android-based mobile devices (2012)

We developed an application for Android™-based mobile devices that allows real-time electrocardiogram (ECG) monitoring and automated arrhythmia detection by analyzing ECG parameters. ECG data provided by pre-recorded files or acquired live by accessing a Shimmer™ sensor node via Bluetooth™ can be processed and evaluated. The application is based on the Pan-Tompkins algorithm for QRS-detection and contains further algorithm blocks to detect abnormal heartbeats. The algorithm was validated using the MIT-BIH Arrhythmia and MIT-BIH Supraventricular Arrhythmia databases. More than 99% of all QRS complexes were detected correctly by the algorithm. Overall sensitivity for abnormal beat detection was 89.5% with a specificity of 80.6%. The application is available for download and may be used for real-time ECG-monitoring on mobile devices.
Uric Acid Reduces Brain Damage and Improves the Benefits of rt-PA in a Rat Model of Thromboembolic Stroke (2006)

Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats. Here we sought to investigate whether uric acid was protective in a model of thromboembolic brain ischemia in rats, and whether the global benefit of recombinant tissue plasminogen activator (rt-PA) was improved by the combined treatment. Adult male Sprague-Dawley rats underwent either ischemia by thromboembolic middle cerebral artery occlusion (MCAO) or sham operation. Uric acid (16 mg/kg) was injected intravenously (i.v.). 20 mins after MCAO, whereas rt-PA (10 mg/kg) was administered i.v. at 3 h. A group of rats received the combined treatment. Rats underwent two neurologic examinations (30 mins and 24 h after MCAO). At 24 h, infarct volume was measured and brain neutrophil infiltration and protein tyrosine nitration were assessed. Treatment with either uric acid or rt-PA reduced infarct volume versus controls (P<0.05). The protective effect against brain ischemia was greater after cotreatment of uric acid with rt-PA (P<0.001), which added further benefit to rt-PA alone (P<0.05). The neurologic score worsened during the first 24 h in treatment controls, whereas it improved in rats receiving uric acid and/or rt-PA. Uric acid strongly reduced ischemia-induced tyrosine nitration, but it was more effective alone than combined with rt-PA, suggesting that reperfusion enhances nitrotyrosine formation. All treatments reduced postischemic brain neutrophil infiltration. These results show that uric acid administered early after thromboembolic stroke is neuroprotective in the rat brain, as it reduces infarct volume, ameliorates the neurologic function, attenuates the inflammatory response, and extends the benefits of rt-PA.
Photocatalytic hydrogen evolution on Si photocathodes modified with bis(thiosemicarbazonato)nickel(<scp>ii</scp>)/Nafion (2019)

The molecular catalyst diacetyl-bis(N-4-methyl-3-thiosemi-carbazonato)nickel(ii) (NiATSM) was integrated with Si for light-driven hydrogen evolution from water. Compared to an equivalent loading of Ni metal, the NiATSM/p-Si electrode performed better. Durability of the surface-bound catalyst under operation in acid was achieved without covalent attachment by using Nafion binding.
Effects of Pervasive Encryption on Operators (2018)

Pervasive Monitoring (PM) attacks on the privacy of Internet users are
of serious concern to both the user and the operator communities.
RFC7258 discussed the critical need to protect users' privacy when
developing IETF specifications and also recognized making networks
unmanageable to mitigate PM is not an acceptable outcome; an
appropriate balance is needed. This document discusses current
security and network operations and management practices that may be
impacted by the shift to increased use of encryption to help guide
protocol development in support of manageable and secure networks.
Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK <sub>1</sub> ) Receptor Antagonist (1991)

CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK1 receptor. The compound binds to a single population of sites in guinea pig brain and potently inhibits substance P-induced excitation of locus ceruleus neurons. CP-96,345 should be a useful tool for studying the action of substance P in the central nervous system.
<i>Lrp6</i> Hypomorphic Mutation Affects Bone Mass Through Bone Resorption in Mice and Impairs Interaction With Mesd (2008)

Low-density lipoprotein receptor-related protein 5 (LRP5) regulates bone acquisition by controlling bone formation. Because roles of LRP6, another co-receptor for Wnts, in postnatal bone metabolism have not been fully elucidated, we studied bone phenotype in mice harboring an Lrp6 hypomorphic mutation, ringelschwanz (rs), and characterized the mutant protein. First, we performed pQCT, bone histomorphometry, and immunohistochemistry on tibias of Lrp6(rs/rs) and Lrp6(+/+) mice and determined biochemical parameters for bone turnover. Lrp6(rs/rs) mice exhibited reduced trabecular BMD in pQCT. Bone histomorphometry showed low bone volume and decreased trabecular number, which were associated with increased eroded surface. Urinary deoxypyridinoline excretion was increased in Lrp6(rs/rs) mice, whereas levels of serum osteocalcin were comparable between Lrp6(rs/rs) mice and wildtype littermates. Increase in cell number and mineralization of calvariae-derived osteoblasts were not impaired in Lrp6(rs/rs) osteoblasts. Rankl expression was increased in Lrp6(rs/rs) osteoblasts both in vivo and in vitro, and osteoclastogenesis and bone-resorbing activity in vitro were accelerated in Lrp6(rs/rs) cells. Treatment with canonical Wnt suppressed Rankl expression in both in primary osteoblasts and ST2 cells. Overexpression of Lrp6 also suppressed Rankl expression, whereas the Lrp6 rs mutant protein did not. Functional analyses of the Lrp6 rs mutant showed decreased targeting to plasma membrane because of reduced interaction with Mesoderm development (Mesd), a chaperone for Lrp6, leading to impaired Wnt/beta-catenin signaling. These results indicate that Lrp6-mediated signaling controls postnatal bone mass, at least partly through the regulation of bone resorption. It is also suggested that the interaction with Mesd is critical for Lrp6 to function.
Scheduling with Deadlines and Loss Functions (1959)

The problem of this paper is that of scheduling several one-stage tasks on several processors, which are capable of handling the tasks with varying degrees of efficiency, to minimize the total loss, which is a sum of losses associated with the individual tasks. Each task has a deadline; the individual loss associated with it is a function of amount of time between the deadline and the time of completion if the former precedes the latter, and zero otherwise.
Enzyme dual-electrode for analyte determination (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzyme dual-electrode for analyte determinationH. Allen O. Hill, Napthali A. Klein, Ioanna S. M. Psalti, and Nicholas J. WaltonCite this: Anal. Chem. 1989, 61, 19, 2200–2206Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/ac00194a017https://doi.org/10.1021/ac00194a017research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A capacitor-less low drop-out voltage regulator with fast transient response (2006)

Power management has had an ever increasing role in the present electronic industry.\nBattery powered and handheld applications require power management techniques to extend the\nlife of the battery and consequently the operation life of the device. Most systems incorporate\nseveral voltage regulators which supply various subsystems and provide isolation among such\nsubsystems. Low dropout (LDO) voltage regulators are generally used to supply low voltage,\nlow noise analog circuitry. Each LDO regulator demands a large external capacitor, in the range\nof a few microfarads, to perform. These external capacitors occupy valuable board space,\nincrease the IC pin count, and prohibit system-on-chip (SoC) solutions.\nThe presented research provides a solution to the present bulky external capacitor LDO\nvoltage regulators with a capacitor-less LDO architecture. The large external capacitor was\ncompletely removed and replaced with a reasonable 100pF internal output capacitor, allowing\nfor greater power system integration for SoC applications. A new compensation scheme is\npresented that provides both a fast transient response and full range ac stability from a 0mA to\n50mA load current. A 50mA, 2.8V, capacitor-less LDO voltage regulator was fabricated in a\nTSMC 0.35um CMOS technology, consuming only 65uA of ground current with a dropout\nvoltage of 200mV.\nExperimental results show that the proposed capacitor-less LDO voltage regulator exceeds\nthe current published works in both transient response and ac stability. The architecture is also\nless sensitive to process variation and loading conditions. Thus, the presented capacitor-less\nLDO voltage regulator is suitable for SoC solutions.
Molecular species of phospholipid in rat hepatomas and in fetal, regenerating, and adult rat livers. (1984)

The molecular species of phospholipid in rat hepatomas were found to be different from those in normal adult liver. Phosphatidylcholine in Yoshida hepatoma contained phosphatidylcholine with 34:1 as the sums of the chain length and of the unsaturation of fatty acids esterified at C-1 and C-2 of glycerol, as an example (PC34:1), PC36:2, PC36:1, PC34:2, and PC36:3, and its phosphatidylethanolamine contained PE36:2, PE36:1, PE38:4, PE36:3, and PE34:1 as major species, whereas phosphatidylcholine in normal adult liver contained PC38:4, PC36:2, PC34:2, PC36:4, and PC34:1, and its phosphatidylethanolamine (PE) contained PE38:4, PE38:6, PE40:6, PE36:4, and PE36:2, with their level decreasing in that order. While Morris hepatoma also had significantly lower amounts of species containing polyunsaturated fatty acids, there were higher levels of those phosphoglycerides containing monoenoic and dienoic fatty acids. Regenerating liver showed similar patterns of molecular species of both phospholipids to those of normal liver. In contrast, fetal liver had similar molecular species of phosphatidycholine to those of hepatomas, but had similar species of phosphatidylethanolamine to those of normal and regenerating livers.
Un impianto di distillazione con caratteristiche innovative nella tecnologia di raffinazione di oli di sansa (1988)

A model of short path distillation plant has been experimented in the physical refining of sunflower oil. Results and discussion are reported about its effects of deep neutralization, of partial deodorization and wax separation in protective operating conditions Calculation methods and comparative tests devoted to the optimization of the working conditions are shown
Simple and Sensitive Fluorescent and Electrochemical Trinitrotoluene Sensors Based on Aqueous Carbon Dots (2015)

Aqueous N-rich carbon dots (CDs), prepared by the microwave-assisted pyrolysis method, are applied as a dual sensing platform for both the fluorescent and electrochemical detection of 2,4,6-trinitrotoluene (TNT). The fluorescent sensing platform is established on the strong TNT-amino interaction which can quench the photoluminescence of amino functionalized CDs through charge transfer. The resultant linear detection ranges from 10 nM to 1.5 μM with a fast response time of 30 s. Glassy carbon electrode modified with CDs exhibits a fine capability for TNT reduction with the linear range from 5 nM to 30 μM, better than that obtained by the fluorescent method. Moreover, the minimum distinguishable response concentration with respect to these two methods is down to the nanomolar level with a high specificity and sensitivity.
Electroterapia: datos para una historia (1998)

espanolMediante el presente trabajo exponemos, distribuidos en varios capitulos, un conjunto de datos que consideramos importantes a la hora de conocer la evolucion que han seguido los conocimientos sobre la electroterapia. Desde los origenes del descubrimiento de la electricidad hasta el uso terapeutico de la misma (no solo de forma directa, sino tambien de aquellos procedimientos en los que esta se transforma en otras clases de energias, como la luz, los ultrasonidos, los campos magneticos, etc.), presentamos estos guiones totalmente abiertos a la investigacion, pues nuestra intencion no es otra que ir aportando elementos, a modo de pilares que nos sirvan para la construccion de una historia de la electroterapia, en el conjunto de la Fisioterapia en particular y de las ciencias de la salud en general. EnglishIn this piece of work we expound, throughout severa! thapters, data which we consider importan! to understand the evolution of knowledge of electrotherapy. From the origins of the discovery of electricity, to its use as a therapy (not only directly but also through procedures where it is transformed into other types of energy, such as light, ultrasound, magnetic fields, etc.), we offer guideliries which are open to investigation since our only intention is to contribute elements, like pillars which can be used to construct a history of electrotherapy, within Physiotherapy in particular and health science in general.
Crystallographic Study of Steps along the Reaction Pathway of <scp>d</scp>-Amino Acid Aminotransferase<sup>,</sup> (1998)

The three-dimensional structures of two forms of the D-amino acid aminotransferase (D-aAT) from Bacillus sp. YM-1 have been determined crystallographically: the pyridoxal phosphate (PLP) form and a complex with the reduced analogue of the external aldimine, N-(5'-phosphopyridoxyl)-d-alanine (PPDA). Together with the previously reported pyridoxamine phosphate form of the enzyme [Sugio et al. (1995) Biochemistry 34, 9661], these structures allow us to describe the pathway of the enzymatic reaction in structural terms. A major determinant of the enzyme's stereospecificity for D-amino acids is a group of three residues (Tyr30, Arg98, and His100, with the latter two contributed by the neighboring subunit) forming four hydrogen bonds to the substrate alpha-carboxyl group. The replacement by hydrophobic groups of the homologous residues of the branched chain L-amino acid aminotransferase (which has a similar fold) could explain its opposite stereospecificity. As in L-aspartate aminotransferase (L-AspAT), the cofactor in D-aAT tilts (around its phosphate group and N1 as pivots) away from the catalytic lysine 145 and the protein face in the course of the reaction. Unlike L-AspAT, D-aAT shows no other significant conformational changes during the reaction.
UNSTEADY MOVEMENT OF FRESH WATER IN THICK UNCONFINED SALINE AQUIFERS (1968)

Abstract Fresh-water lenses are formed in unconfined saline aquifers in response to deep percolation from rainfall, artificial recharge, and seepage from irrigation waters and/or in response to injecting fresh water through vertical or horizontal wells. An approximate differential equation is derived in terms of the depth of the fresh-salt water interface below the initial position of the saline-water table. This equation is analogous to that of the ground-water motion in two dimensions. The wealth of knowledge available from solving the latter equation is used to obtain approximate expressions for the movement of the fresh-salt water interface in several flow systems wherein this interface does not reach the bottom of the aquifer. These approximate solutions as well as others for related quantities of interest may afford useful tools for rationally planning the extraction of usable waters from such flow systems.
Involvement of Co-activator p300 in the Transcriptional Regulation of the HER-2/neu Gene (1997)

Overexpression of HER-2/neu is frequently found in human cancer and has been shown to enhance the metastatic potential of tumors and to induce the chemoresistance of cancer cells. The molecular mechanism(s) by which HER-2/neu expression is deregulated in cancer is not clear. We reported previously that adenovirus 5 E1A is capable of transcriptionally repressing the HER-2/neu promoter. We report here that the E1A-associated p300 protein can derepress the E1A-mediated repression of HER-2/neu in a dose-dependent manner. A p300 mutant, which lost its ability to bind to E1A, also effectively rescued the repressed HER-2/neu promoter in the presence of excess E1A inside the cells. A protein complex can bind to the p300 consensus sequences in HER-2/neu promoter. The intensity of the retarded band of the protein complex decreased significantly after preincubation of the nuclear extracts with beads that has been conjugated with anti-p300 antibody. The binding of E1A to p300 and the p300 consensus sequence in HER-2/neu promoter were crucial for the ability of E1A to repress HER-2/neu promoter, demonstrating that p300 is involved in the transcriptional regulation of HER-2/neu and serves as a target for E1A repression.
The Genome Sequence of <i>Drosophila melanogaster</i> (2000)

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes approximately 13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.
Very thin Fe/Ni modulation multilayer films under ion bombardment (1997)

We investigated the effect of noble gas irradiation (He, Ne, and Xe) on Fe–Ni multilayers with a very thin modulation and nominal composition in the Invar region Fe0.63Ni0.37. The evaluation of the formation/stability of the Fe–Ni phases formed under irradiation with different ions and doses was followed by conversion electron Mössbauer spectroscopy. The magnetic hysteresis curves were also obtained in order to correlate the hyperfine pattern with magnetic properties. The as-deposited sample reveals mainly the characteristic α-Fe while He- and Ne-irradiated samples clearly show a phase transformation with segregation of γ-FeNi phases with different Ni concentrations, a magnetic atomically ordered phase (∼50% Ni), and a nonmagnetic phase (⩽30% Ni). However, mixing with Ne is more effective than with He for similar doses. The results obtained with Xe showed a large distribution of hyperfine fields similarly to previous results reported for Kr [C. Tosello, F. Ferrari, R. Brand, W. Keune, G. Marest, M. A. El Khakani, J. Parellada, G. Principi, S. Lo Russo, V. Rigato, and S. Enzo, Nucl. Instrum. Methods B 80/81, 417 (1993)].