gebhart/patrepeval huggingface dataset:
Urban Propagation Modeling for Wireless Systems (2004)

Abstract : Measurements taken in the San Francisco financial district provide new descriptions of propagation effects and extend existing propagation models to quantify the repeatability of signal variation assumed by new resource allocation techniques. The financial district is a flat portion of the city comprising a grid-like pattern of streets surrounded by buildings up to 160m tall and is like many areas that are now experiencing network congestion. Changes of 15-25 dB in signal strength are known to occur in the vicinity of intersections and along orthogonal streets. Previously not studied, the signal strength's rate of change determines how quickly the system must respond to loss of signal quality. The sudden change in signal level at street corners requires an averaging window of less than 5 wavelengths to determine the local average power. A new partitioning technique incorporates the layout of streets to reduce the prediction error of existing path loss models by up to 6 dB. Using a new model, repeatability of large- and small-scale signal variations is quantified over a 15-month period.
Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase (2014)

Human RAD51 protein catalyzes DNA pairing and strand exchange reactions that are central to homologous recombination and homology-directed DNA repair. Successful recombination/repair requires the formation of a presynaptic filament of RAD51 on ssDNA. Mutations in BRCA2 and other proteins that control RAD51 activity are associated with human cancer. Here we describe a set of mutations associated with human breast tumors that occur in a common structural motif of RAD51. Tumor-associated D149N, R150Q and G151D mutations map to a Schellman loop motif located on the surface of the RecA homology domain of RAD51. All three variants are proficient in DNA strand exchange, but G151D is slightly more sensitive to salt than wild-type (WT). Both G151D and R150Q exhibit markedly lower catalytic efficiency for adenosine triphosphate hydrolysis compared to WT. All three mutations alter the physical properties of RAD51 nucleoprotein filaments, with G151D showing the most dramatic changes. G151D forms mixed nucleoprotein filaments with WT RAD51 that have intermediate properties compared to unmixed filaments. These findings raise the possibility that mutations in RAD51 itself may contribute to genome instability in tumor cells, either directly through changes in recombinase properties, or indirectly through changes in interactions with regulatory proteins.
Fast Construction of Suffix Arrays for DNA Strings (2007)

To perform fast searching in massive data such as DNA strings, the most efficient method is to construct full-text index data structures of given strings. The widely used full-text index structures are suffix trees and suffix arrays. Since the suffix may uses less space than the suffix tree, the suffix array is proper for DNA strings. Previously developed construction algorithms of suffix arrays are not suitable for DNA strings since those are designed for integer alphabets. We propose a fast algorithm to construct suffix arrays on DNA strings whose alphabet sizes are fixed by 4. We reduce the construction time by improving encoding and merging steps on Kim et al.[1]'s algorithm. Experimental results show that our algorithm constructs suffix arrays on DNA strings 1.3-1.6 times faster than Kim et al.'s algorithm, and also for other algorithms in most cases.
Novel NMR approach to assessing gene transfection: 4‐fluoro‐2‐nitrophenyl‐β‐<scp>D</scp>‐galactopyranoside as a prototype reporter molecule for β‐galactosidase (2004)

Gene therapy holds great promise for the treatment of diverse diseases. However, widespread implementation is hindered by difficulties in assessing the success of transfection in terms of spatial extent, gene expression, and longevity of expression. The development of noninvasive reporter techniques based on appropriate molecules and imaging modalities may help to assay gene expression. 4-Fluoro-2-nitrophenyl-beta-D-galactopyranoside (PFONPG) is a novel prototype NMR-sensitive molecule, which is highly responsive to the action of beta-galactosidase (beta-gal), the product of the lacZ gene. The molecule is stable in solution and with respect to wild-type cells, but the enzyme causes very rapid liberation of the aglycone, accompanied by color formation and a 19F NMR chemical shift of 5-10 ppm, depending on pH. Since the product is pH-sensitive, this opens the possibility for direct pH determinations at the site of enzyme activity. Molecular and 19F NMR characteristics of PFONPG in solution, blood, and prostate tumor cells are presented. This prototype molecule facilitates a novel approach for assaying gene activity in vivo.
Microfabrication of Ceramics by Filling of Photoresist Molds (2000)

Filling of photo-resist molds is a new method for the generation of micropatterned ceramic surfaces. A flat substrate is first patterned with a photoresist. The ceramic coating is then applied to the substrates by pouring 50 vol.-% alumina suspension over the mold, excess material being removed with a polymer blade (see Figure). Alumina structures of high quality were produced on silicon wafers and on sapphire single crystals.
Defragmentation of Transparent Flexible Optical WDM (FWDM) Networks (2011)

We introduce the network defragmentation problem for FWDM networks, formulate it, and propose heuristics. The network defragmentation process consolidates the available spectrum significantly while minimizing the number of interrupted connections.
The Selective Recovery of Alcohols from Fermentation Broths by Pervaporation (1990)

Abstract Pervaporation can be successfully utilized to recover various alcohols from fermentation broths and dilute process streams. Hydrophobic membranes, such as silicone-based polymers, have been employed in this application to produce an enriched product. Research in this field has increased dramatically in the past five years and a review of this work is warranted. Fermentations of n-butanol, ethanol, and isopropanol all yielded positive results. The direct integration of a membrane with a bioreactor makes the process more efficient and reduces the effects of product inhibition. A majority of researchers have investigated selective organic permeation from binary aqueous mixtures. These results provide an excellent data base on the permeabilities of alcohols through various membranes. This paper specifically addresses the application of pervaporation to the selective permeation of alcohols from dilute mixtures with particular reference to fermentation broths.
Seal Formation in Silicon Planar Patch-Clamp Microstructures (2008)

This paper presents a microfabricated planar patch-clamp electrode design and looks at the impact of several physical characteristics on seal formation. The device consists of a patch aperture, 1.5-2.5 mum in diameter and 7-12 mum in depth, with a reverse-side deep-etched 80-mum well. The patch aperture was coated with either thermal oxide or plasma-enhanced chemical vapor deposited (PECVD) SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> . Some of the thermal oxide devices were converted into protruding nozzle structures, and some were boron-doped. Seal formation was tested with cultured N2a neuroblastoma cells. The PECVD oxide devices produced an average seal resistance of 34 MOmega(n = 24), and the thermal oxide devices produced an average seal resistance of 96 MOmega(n = 59). Seal resistance was found to positively correlate with patch aperture depth. Whole-cell recordings were obtained from 14% of cells tested with the thermal oxide devices, including a single recording where a gigaohm seal was obtained.
Early initiation of enzyme replacement therapy for the mucopolysaccharidoses (2013)

The mucopolysaccharidoses (MPS), a group of rare genetic disorders caused by defects in glycosaminoglycan (GAG) catabolism, are progressive, multi-systemic diseases with a high burden of morbidity. Enzyme replacement therapy (ERT) is available for MPS I, II, and VI, and may improve walking ability, endurance, and pulmonary function as evidenced by data from pivotal trials and extension studies. Despite these demonstrable benefits, cardiac valve disease, joint disease, and skeletal disease, all of which cause significant morbidity, do not generally improve with ERT if pathological changes are already established. Airway disease improves, but usually does not normalize. These limitations can be well understood by considering the varied functions of GAG in the body. Disruption of GAG catabolism has far-reaching effects due to the triggering of secondary pathogenic cascades. It appears that many of the consequences of these secondary pathogenic events, while they may improve on treatment, cannot be fully corrected even with long-term exposure to enzyme, thereby supporting the treatment of patients with MPS before the onset of clinical disease. This review examines the data from clinical trials and other studies in human patients to explore the limits of ERT as currently used, then discusses the pathophysiology, fetal tissue studies, animal studies, and sibling reports to explore the question of how early to treat an MPS patient with a firm diagnosis. The review is followed by an expert opinion on the rationale for and the benefits of early treatment.
Physiological responses to sublethal hydrostatic pressure in <b> <i>Yarrowia lipolytica</i> </b> (1997)

Journal Article Physiological responses to sublethal hydrostatic pressure in Yarrowia lipolytica Get access R. Lanciotti, R. Lanciotti Istituto di Produzioni e Preparazioni Alimentari, Università degli Studi di Bari, sede di Foggia, Foggia Search for other works by this author on: Oxford Academic Google Scholar F. Gardini, F. Gardini Dipartimento di Protezione e Valorizzazione Agroalimentare, Università degli Studi di Bologna, Bologna, Italy Search for other works by this author on: Oxford Academic Google Scholar M. Sinigaglia, M. Sinigaglia Istituto di Produzioni e Preparazioni Alimentari, Università degli Studi di Bari, sede di Foggia, Foggia Search for other works by this author on: Oxford Academic Google Scholar M. E. Guerzoni M. E. Guerzoni Dipartimento di Protezione e Valorizzazione Agroalimentare, Università degli Studi di Bologna, Bologna, Italy Dr M. E. Guerzoni Dipartimento di Protezione e Valorizzazione Agroalimentare, Università degli Studi di Bologna, Via S. Giacomo 7, 40126 Bologna, Italy. Search for other works by this author on: Oxford Academic Google Scholar Letters in Applied Microbiology, Volume 24, Issue 1, 1 January 1997, Pages 27–32, https://doi.org/10.1046/j.1472-765X.1997.00332.x Published: 01 January 1997 Article history Received: 26 April 1996 Accepted: 04 June 1996 Published: 01 January 1997
Testing the 3-factor model of occupational stress: The impact of demands, control and social support on a mail sorting task (1999)

This study tests a 3-factor model of occupational stress, which predicts that job demands, job control and social support influence levels of strain. In a laboratory simulation of mail sorting, task demands, control and social supports were manipulated systematically. Pre- and post-task measures of self reported stress and arousal were compared across groups. Performance was measured continuously during the computer task and all 120 participants reported their perceived performance afterwards. Stress was found to be higher and perceived performance was lower in conditions of high demand; this pattern was also observed in conditions of low social support. Contrary to the hypotheses put forward in this paper, task control did not affect stress and the manipulations did not interact to produce elevated stress. However, task performance was poorer in conditions of high demand and in conditions of low control, and there was a significant interaction between demand and control for performance. Work preference measures indicated that the level of fit between ideal and actual social support influenced stress and perceived performance. Keywords: StressPerformanceKarasekComputer Simulation
Octane Enhancers (2009)

Abstract The article contains sections titled: 1. Introduction 2. Technical Information 2.1. Combustion in Otto Engines 2.2. Knock Phenomena 2.3. Octane Number 3. Types of Octane Enhancers 4. Metal‐Containing Additives 4.1. Alkyl Lead Compounds 4.2. Methylcyclopentadienylmanganese Tricarbonyl 5. Ashless Octane Enhancers 5.1. Heteroatom‐Based Components 5.1.1. History of Fuel Oxygenates 5.1.2. Properties of Oxygenates 5.1.3. Production 5.1.4. Toxicology 5.2. Pure Hydrocarbon Components
Computed tomographic studies of the head in a teaching hospital and a community hospital: a comparison. (1982)

This investigation compared the use of computed tomography (CT) of the head at a large primary medical-school-affiliated hospital and at a large community hospital. There were two aims: first, to study the intrinsic characteristics of the patients in an attempt to determine the potential for developing accurate discrimination algorithms; and second, to study the patterns of neurodiagnostic tests used at these facilities. The results indicated that separability of patients into normal and abnormal categories at both institutions was extremely small. In addition, there was no significant difference in the numbers of types of ancillary tests used at both institutions. Overall, these data once more confirm the difficulty of altering CT usage patterns in primary or secondary hospitals without significantly affecting the number of abnormal patients identified.
Challenges for the pharmaceutical technical development of protein coformulations (2017)

The complexity of the dosage form and the protein molecules results into additional challenges to formulation, manufacture, storage, transport, handling and patient administration, stability and analytics during the pharmaceutical development of protein coformulations. Various points have to be considered during different stages of development in order to obtain a safe and efficacious product.
Comparison of the genomes of simian, bovine, and human rotaviruses by gel electrophoresis and detection of genomic variation among bovine isolates (1979)

By co-electrophoresis in polyacrylamide gels, the segmented double-standed RNA genome of the simian rotavirus, SA 11, was compared with those of human and bovine rotaviruses. A comparison between SA 11 virus and the Northern Ireland cell culture adapted bovine virus showed that the electrophoretic mobilities of each of the 11 corresponding segments differed. In other comparisons, four to seven segment variations were more common. When the genomes of various bovine rotaviruses were compared, eight different electropherotypes were detected. Four of these electropherotypes were obtained from one property during a single outbreak of disease. In view of such genetic diversity, a scheme for the systematic designation of different rotavirus samples is proposed. The significance of the variations in relation to the molecular epidemiology of bovine rotavirus infections is discussed.
Reference Electrodes for High Pressure and High Temperature Electrochemical Testing (2001)

Abstract Current developments and progress in design of high temperature reference electrodes are reviewed. The basic principles required to design reference electrodes are described focusing on the main issues that should be addressed for high temperature applications. Various high temperature electrode designs are classified by the thermal state of the cell (external, internal), their performance based on long term stability and the potential determination reaction.
Interoperability of Wireless Mesh and Wi-Fi network using FPGA for 4G solutions (2011)

Wireless Mesh Network (WMNs) is a fast, easy and inexpensive solution for broadband wireless access which has drawn significant attention from industry and academic for the past few years. Development of the future infrastructure, collectively and loosely called 4G systems, is focusing on delivering higher speed and higher capacity at much lower cost. Interoperability and compatibility of emerging trends with existing systems is a prime factor for 4G solutions. One important characteristics of WMNs is various heterogeneous networks such as Wi-Fi, Wi-Max, sensor and cellular network can be integrated with Wireless Mesh Networks. Different types of networks use different standards for their communication. In this paper we proposed FPGA based algorithm which will convert Wi-Fi standard to IEEE 802.11s -a mesh standard. To enhance the hardware performance of WMNs, we have designed WMNs using FPGA. And also we propose the design, implementation and simulation of 802.11s based WMNs with the integration of Wi-Fi network in HDL platform(Hardware Description Language). The FPGA simulation environment, provides the complete functional behaviour of the WMNs with 802.11s MAC layer specifications.
Stress and Emotion Classification using Jitter and Shimmer Features (2007)

In this paper, we evaluate the use of appended jitter and shimmer speech features for the classification of human speaking styles and of animal vocalization arousal levels. Jitter and shimmer features are extracted from the fundamental frequency contour and added to baseline spectral features, specifically Mel-frequency cepstral coefficients (MFCCs) for human speech and Greenwood function cepstral coefficients (GFCCs) for animal vocalizations. Hidden Markov models (HMMs) with Gaussian mixture models (GMMs) state distributions are used for classification. The appended jitter and shimmer features result in an increase in classification accuracy for several illustrative datasets, including the SUSAS dataset for human speaking styles as well as vocalizations labeled by arousal level for African elephant and Rhesus monkey species.
Studies on the crystalline lens. IV. Distribution of cytochrome, total riboflavin, lactate, and pyruvate and their metabolic significance. (1951)

THE ENZYME systems involved in the respiration of the lens have not been established. Whereas many attempts have been made to demonstrate that the same enzymes—flavoprotein and cytochrome-cytochrome oxidase1—which catalyze oxygen uptake in other tissues also function in this capacity in the lens, the only direct evidence, to our knowledge, for the existence of a flavoprotein or a cytochrome-cytochrome oxidase system in the lens is that obtained by Philpot and Pirie.2These authors reported two analytical values for the riboflavin content of the lens. Using the microbiologic method of assay, they found that lenses devoid of capsule, and presumably therefore of epithelium, contained in the two instances 0.05 and 0.12 γ of riboflavin per gram of wet weight. Other investigators3failed to detect riboflavin or flavoprotein in the lens by fluoroscopic methods. Von Euler and Gunther3band Burdon-Cooper and Lewis4were unable to demonstrate
Technology trends of silicon-on-insulator-its advantages and problems to be solved (2002)

Recent progress in SOI technology is reviewed and problems which need be solved are discussed. Emphasis is placed on the substrate floating effect, for which the bandgap engineering method is proposed for the first time. It is demonstrated that Si-Ge formation in the source region can improve the drain breakdown voltage significantly.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Medidas Alternativas de Inflación Subyacente para Chile (2008)

Normalmente, los bancos centrales con metas de inflacion tienen objetivos basados en inflacion total, la cual frecuentemente se ve afectada por movimientos de precios en componentes especificos cuyo comportamiento hace dificil extraer senales claras respecto de la evolucion del panorama inflacionario relevante dentro del horizonte de la politica monetaria. Dado esto, se han propuesto distintas medidas de inflacion subyacente que tienen como objetivo remover este �ruido�. En este trabajo se presentan algunas alternativas calculadas para la economia chilena: tres distintos indicadores que podan componentes del IPC total segun criterios de variacion y volatilidad, y dos medidas que reponderan segun la volatilidad historica. En terminos generales, se encuentra que las medidas que podan los items con variaciones extremas o con alta volatilidad, son informativas respecto de la evaluacion del panorama inflacionario, dado que son insesgadas respecto del IPC, cuando se ajusta por estacionalidad, y tienen un desempeno superior a otras medidas para seguir la tendencia de la inflacion total.
Powerful dienophiles for asymmetric Diels-Alder reactions: .alpha.-(2-exo-hydroxy-10-bornylsulfinyl)maleimides (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPowerful dienophiles for asymmetric Diels-Alder reactions: .alpha.-(2-exo-hydroxy-10-bornylsulfinyl)maleimidesYoshitsugu Arai, Makoto Matsui, Toru Koizumi, and Motoo ShiroCite this: J. Org. Chem. 1991, 56, 6, 1983–1985Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://doi.org/10.1021/jo00006a005RIGHTS & PERMISSIONSArticle Views422Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (362 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The role of stress in neurodegenerative diseases and mental disorders. (2002)

Stress has a major impact upon neurodegenerative diseases and mental disorders. It plays a significant role in susceptibility, progress, and actual outcome. Also, subjective or individual differences have to be taken into account. However, stress - especially 'adequate' acute stress (stress that is not overwhelming) - may even improve performance/biological functions and be beneficial in certain cases.
The novel human beta‐defensin‐3 is widely expressed in oral tissues (2002)

The purpose of this study was to investigate the expression of human beta‐defensins (hBD), especially of the recently discovered hBD‐3, in oral tissues by reverse‐transcription polymerase chain reaction (RT‐PCR). Primary oral keratinocytes ( n = 3) and fibroblasts ( n = 3), 64 non‐inflamed and 40 inflamed oral tissue samples, and 10 samples of salivary glands, were examined. The transcripts for hBD‐3 (61/64), as well as for hBD‐1 (64/64) and hBD‐2 (54/64), were found to be widely expressed in non‐inflamed oral tissues. In contrast, only 23, 22 and 24 of the 40 inflamed tissues showed detectable hBD‐1, ‐2 and ‐3 transcripts, respectively. In salivary glands, mRNA expression was constitutive for hBD‐1, frequent for hBD‐2 (9/10), and infrequent for hBD‐3 (4/10). Oral keratinocytes, but not fibroblasts, contained transcripts for all beta‐defensins, suggesting that the novel hBD‐3 is also produced in the epithelial compartment of oral tissues. The results indicate an important role for the novel hBD‐3, as well as for hBD‐1 and hBD‐2, in the innate oral epithelial host defense.