gebhart/patrepeval huggingface dataset:
Nested-Current-Mirror Rail-to-Rail-Output Single-Stage Amplifier With Enhancements of DC Gain, GBW and Slew Rate (2015)

For better area and power efficiencies, rail-to-rail-output single-stage amplifiers are a potential replacement of their multi-stage counterparts, especially for display applications that entail massive buffer amplifiers in their column drivers. This paper describes a nested-current-mirror (NCM) technique for a single-stage amplifier to achieve substantial enhancements of DC gain, gain-bandwidth product (GBW) and slew rate (SR). Specifically, NCM is customizable for different mirror steps, and sub mirror ratios, to balance the performance metrics and capacitive-load ( CL) drivability, avoiding any compensation passives while preserving a rail-to-rail output swing. Analytical treatments of the NCM technique in terms of performance limits and robustness reveal that the NCM amplifier can surpass the fundamental power-efficiency limit set by the basic differential-pair (DP) amplifier. Two prototypes, 3-step and 4-step NCM amplifiers, were fabricated in 0.18 μm CMOS for systematic comparison with the DP amplifier. The former represents a robust design exhibiting 72 dB DC gain and 0.0028-0.27 MHz GBW over 0.15-15 nF CL with 80 ° phase margin (PM). The latter embodies an aggressive design attaining 84 dB DC gain and 0.013-1.24 MHz GBW over 0.15-15 nF CL with 62 ° PM. All amplifiers were sized for the same area (0.0013 mm 2) and power (3.6 μW).
Short Notices (1948)

Journal Article Short Notices Get access G. G. Van D. G. G. Van D. Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume LXIII, Issue CCXLVII, April 1948, Pages 280-b–281, https://doi.org/10.1093/ehr/LXIII.CCXLVII.280-b Published: 01 April 1948
System-level performance phase characterization for on-demand resource provisioning (2007)

The thrust of this paper is to profile the execution phases of applications, which helps optimize the efficiency of the underlying resources. Here we present a novel system-level application-resource-demand phase analysis and prediction approach in support of on-demand resource provisioning. The process we follow is to explore large-scale behavior of applications’ resource consumption, followed by analysis using a set of algorithms based on clustering. The phase profile, which learns from historical runs, is used to classify and predict future phase behavior. This process takes into consideration applications’s resource consumption patterns, phase transition costs and penalties associated with Service-Level Agreements (SLA) violations. Our experimental results with WorldCup98 replay web access logs show that prediction accuracies around 84% or larger for ten-phase cases can be achieved for network performance traces.
Features, Treatment, and Outcomes of Macrophage Activation Syndrome in Childhood‐Onset Systemic Lupus Erythematosus (2018)

MAS was most likely to develop concomitantly with childhood-onset SLE diagnosis. The majority of the MAS patients were successfully treated with corticosteroids with no MAS relapses. Although the numbers were small, there was a higher risk of death associated with MAS compared to SLE without MAS.
REB1, a yeast DNA-binding protein with many targets, is essential for growth and bears some resemblance to the oncogene myb. (1990)

REB1 is a DNA-binding protein that recognizes sites within both the enhancer and the promoter of rRNA transcription as well as upstream of many genes transcribed by RNA polymerase II. We report here the cloning of the gene for REB1 by screening a yeast genomic lambda gt11 library with specific oligonucleotides containing the REB1 binding site consensus sequence. The REB1 gene was sequenced, revealing an open reading frame encoding 809 amino acids. The predicted protein was highly hydrophilic, with numerous OH-containing amino acids and glutamines, features common to many of the general DNA-binding proteins of Saccharomyces cerevisiae, such as ABF1, RAP1, GCN4, and HSF1. There was some homology between a portion of REB1 and the DNA-binding domain of the oncogene myb. REB1 is an essential gene that maps on chromosome II. However, the physiological role that it plays in the cell has yet to be established.
Developmental Implications of Clinically Applied Vestibular Stimulation (1983)

Recent research has promoted the development of several techniques that use various forms of sensory stimulation to improve the neuromotor development of high-risk infants and developmentally delayed children. One of the newest and most popular adjuncts to therapy for developmentally delayed children is vestibular stimulation. The applied clinical research using vestibular stimulation activities with healthy human infants, infants at risk, and young children with developmental delay disorders is reviewed. The literature discussed indicates that controlled vestibular stimulation has had positive effects on arousal level, visual exploratory behavior, motor development, and reflex integration. Also discussed is the need for continued applied clinical research to further substantiate the most effective type of vestibular stimulation and the population for which such stimulation is most beneficial.
AT<sub>2</sub> receptor stimulation induces generation of ceramides in PC12W cells (1999)

The angiotensin AT2 receptor has been implicated in both regeneration and apoptosis. To further investigate the molecular mechanisms leading to AT2 receptor-induced programmed cell death in PC12W cells we studied the effects of angiotensin II (ANG II) on ceramide levels by HPTLC analysis. We could demonstrate that ANG II time- (1-10 h) and dose-dependently (10(-8)-5 X 10(-6) M) increased ceramide levels by maximally 175% but did not affect sphingomyelin degradation. The ANG 11 effects were mediated by AT2 receptors since they were completely abolished by co-incubation with the AT2 receptor antagonist, PD123177 (10(-5) M), but not by the AT1 receptor antagonist, losartan (10(-5) M). These data suggest a novel signal transduction pathway to the AT2 receptor leading to apoptosis in neuronal cells.
NAD‐Dependent Formate Dehydrogenase from Methylotrophic Bacterium, Strain 1 (1979)

1. NAD-dependent formate dehydrogenase was isolated from gram-negative methylotrophic bacteria, strain 1, grown on methanol. The purification procedure involved ammonium sulfate fractionation, ion-exchange chromatography and preparative isotachophoresis or gel filtration; it resulted in a yield of 40%. 2. The final enzyme preparations were homogeneous as judged by sedimentation in an ultracentrifuge. Formate dehydrogenase purified in the presence of EDTA reveals two bands on electrophoresis in polyacrylamide gel both after protein and activity staining. Two components are transformed into a single one after prolonged storage in the presence of 2-mercaptoethanol. 3. Formate dehydrogenase is a dimer composed of identical or very similar subunits. The molecular weight of the enzyme is about 80 000. 4. Amino acid composition and some other physico-chemical properties of the enzyme were studied. 5. Formate dehydrogenase is specific for formate and NAD as electron acceptor. The Michaelis constant was 0.11 mM for NAD and 15 mM for formate (pH 7.0, 37 degrees C). 6. Formate dehydrogenase was rapidly inactivated in the absence of -SH compounds. The enzyme retained full activity upon storage at ambient temperature in solution for half a year in the presence of 2-mercaptoethanol or EDTA.
Importancia morfológica de las ramas terminales superficiales del nervio trigémino en la estética facial. Revisión de la literatura (2015)

Currently, the facial care and beauty is one of the biggest concerns in society, regardless of age, gender or race. Facial aesthetics emerged as a subspecialty of the Aesthetic Medicine; this practice applies the necessary techniques for the restoration, maintenance, harmony promotion and the well-being of the face, providing beauty and functionality, away from hype and sudden changes. The facial region includes an anatomical territory witch is protected by skin and innervated in sensitive terms by the trigeminal nerve. Specifically sensory perception of three thirds from the skin face is captured by the superficial terminal branches of the trigeminal nerve:supraorbital nerve (terminal branch of the ophthalmic nerve), the infraorbital nerve (terminal branch of the maxillary nerve) and the mental nerve (terminal branch of the mandibular nerve). So, the objective behind developing this review is to contribute with valuable and updated scientific information, to strengthen morphological bases in the study and location of the superficial branches of the trigeminal nerve, strengthening the anatomical importance for clinical localization of sensory terminal branches in this nerve, allowing preventing nerve complications that can occur in this region. It also contributes to the anatomical identification for implementing anesthetic techniques that block pain in the area.
S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship (2002)

We studied the relationship between Parkinson's disease (PD) and the S18Y polymorphism in the UCH-L1 gene and the effect on this relationship of age at onset, smoking, and pesticides. Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29-0.99); there was no association for older patients (62-68 years: OR = 1.21; 95% CI, 0.67-2.20; >68 years: OR = 1.24; 95% CI, 0.67-2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community-based case-control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking.
Design and Implementation of Industrial Firewall for Modbus/TCP (2016)

For the fragile security status and the growing threat of attack on industrial control systems, it is particularly important to strengthen the technology of security protection. After a detailed study of the characteristics of industrial control systems, this paper put forward design scheme of industrial firewall based on Modbus/TCP protocol, combining "white list" security policies with deep packet inspection technology, and realizing on the Linux platform. The experimental results show that the firewall can effectively intercept illegal data stream and ensure the normal operation of the industrial control system.
Inhibition of gastric acid secretion by 1,8-naphthyridin-2(1H)-ones (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInhibition of gastric acid secretion by 1,8-naphthyridin-2(1H)-onesWilliam A. Bolhofer, Jacob M. Hoffman, Charles N. Habecker, Adolph M. Pietruszkiewicz, Edward J. Cragoe Jr., and Mary Lou TorchianaCite this: J. Med. Chem. 1979, 22, 3, 301–306Publication Date (Print):March 1, 1979Publication History Published online1 May 2002Published inissue 1 March 1979https://pubs.acs.org/doi/10.1021/jm00189a016https://doi.org/10.1021/jm00189a016research-articleACS PublicationsRequest reuse permissionsArticle Views135Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The theory, design, implementation and evaluation of a three-dimensional surface detection algorithm (1980)

In many three-dimensional imaging applications the three-dimensional scene is represented by a three-dimensional array of volume elements, or voxels for short. A subset Q of the voxels is specified by some property. The objects in the scene are then defined as subsets of Q formed by voxels which are “connected” in some appropriate sense. It is often of interest to detect and display the surface of an object in the scene, specified say by one of the voxels in it.
A Cloud-User Access Control Mechanism Based on Data Masking (2012)

The development of cloud application provides a diverse storage and sharing platform. These cloud resources will enable us to more quickly and easily share digital information storage. Digital data stored in the cloud platform, the platform files are protected by access control mechanisms to prevent illegal use of other digital files. However, if the cloud platform be intrusion, the attacker may go through the platform authentication mechanisms, access to the host platform digital files directly to obtain these. This will expose digital files secure cloud environment. in this study, such a problem, propose a Data Masking-based access control mechanism. Legal users can use the correct authentication information to restore digital files, that to avoid unauthorized access and misuse. This allows users to more safely use the convenience of cloud resources.
Lubrication mechanisms of hot-dipped tin separable electrical contacts (2002)

Degradation phenomena occurring during the lifetime of tinned separable electrical contacts remain a factor of loss of reliability that can be minimised. In a previous paper, friction, wear and electrical properties of hot-dipped tin coatings on bronze substrates have been analysed with various techniques in order to show the improvement due to a well-suited fluorinated lubricant layer. Contacts were of the sphere on plane type obtained from strips of tinned CuSn/sub 4/ (as received for the flats, and formed by stamping for the dimples). Macroscopic friction cycles simulating insertion and withdrawal of separable contacts were performed as well as fretting cycles. Efficiency of the lubricant was strongly related to the film thickness in the case of macroscopic friction of dimple on flat contacts. For a sufficient film thickness, different behaviours were observed for different molecules. Here, the particularity of lubrication mechanisms of hot-dipped tin contacts is analysed. The evolution of static contact resistance values before friction and during the friction tests correlated to the wear behaviour shows the influence of some of the lubricant properties such as viscosity and chain structure.
Hyperdynamic Circulation and Cardiovascular Risk in Children and Adolescents (1995)

The present study demonstrates that a hyperdynamic state as defined is associated with increased insulin levels and an adverse cardiovascular risk in early life.
初级保健与结直肠癌即——使有全国性筛查，初级保健在降低死亡率方面仍大有可为 (2006)

在减少结直肠癌的公共卫生负担方面，初级保健机构具有坚实的作用。由于结直肠癌在诊断时随病情的进一步进展死亡率越高，而且大部分患者出现症状后会就诊于他们的全科执业医生，因此患者和医生都需要认识那些能预示肿瘤高风险的症状。本期中，du Toit及其同事报道了一项为期10年的前瞻性研究（见第273页），证实了直肠出血作为结直肠癌预警症状的重要性。此项研究发现大约十分之一的新发直肠出血患者有肿瘤。作者认为全科执业医生应对任何一位≥45岁的直肠出血患者进行检查，而无论其是否伴有排便习惯改变。
Malignant hyperthermia during isoflurane anaesthesia (1990)

Two cases are presented which illustrate the essential features, diagnosis and management of malignant hyperthermia. Both cases occurred in association with isoflurane, and in patients who were exposed during previous anaesthetics to recognised trigger agents without apparent manifestation of the syndrome.
Cross-Document Co-Reference Resolution using Sample-Based Clustering with Knowledge Enrichment (2015)

Identifying and linking named entities across information sources is the basis of knowledge acquisition and at the heart of Web search, recommendations, and analytics. An important problem in this context is cross-document co-reference resolution (CCR): computing equivalence classes of textual mentions denoting the same entity, within and across documents. Prior methods employ ranking, clustering, or probabilistic graphical models using syntactic features and distant features from knowledge bases. However, these methods exhibit limitations regarding run-time and robustness. This paper presents the CROCS framework for unsupervised CCR, improving the state of the art in two ways. First, we extend the way knowledge bases are harnessed, by constructing a notion of semantic summaries for intra-document co-reference chains using co-occurring entity mentions belonging to different chains. Second, we reduce the computational cost by a new algorithm that embeds sample-based bisection, using spectral clustering or graph partitioning, in a hierarchical clustering process. This allows scaling up CCR to large corpora. Experiments with three datasets show significant gains in output quality, compared to the best prior methods, and the run-time efficiency of CROCS.
Increased glomerular capillary pressure alters glomerular cytokine expression. (1994)

Increased glomerular capillary hydrostatic pressure (PGC) is an important hemodynamic determinant of glomerular injury, but the molecular events responsible for this association are poorly understood. PGC is normal in spontaneously hypertensive rats (SHR), but uninephrectomy leads to an increase in PGC and accelerated glomerulosclerosis. Since recent studies have implicated transforming growth factor-beta 1 (TGF-beta 1) and platelet-derived growth factor sought to determine if uninephrectomy increased mRNA levels for TGF-beta 1 and PDGF in glomeruli of SHR. Since treatment with the angiotensin-converting enzyme (ACE) inhibitor enalapril lowers PGC and prevents glomerulosclerosis in uninephrectomized SHR, we also sought to determine if ACE inhibitor lowered mRNA levels for TGF-beta 1 and PDGF in the glomeruli of uninephrectomized SHR. PGC increased from 53 +/- 1 to 64 +/- 1 mm Hg 1 week after uninephrectomy in SHR (P < .05). The increase in PGC was associated with a sixfold rise in mRNA levels for TGF-beta 1 and a twofold rise in mRNA levels for PDGF in glomeruli. mRNA levels for PDGF returned to normal 2 weeks after nephrectomy, but the increase in mRNA levels for TGF-beta 1 was sustained. An increase in TGF-beta 1 immunostaining was detectable in glomeruli 4 weeks after nephrectomy. Treatment with ACE inhibitor normalized PGC (51 +/- 1 mm Hg) and prevented the rise in glomerular mRNA levels for TGF-beta 1 and PDGF. We conclude that an acute increase in PGC leads to increased TGF-beta 1 and PDGF expression in the glomerulus, thus linking changes in PGC to cytokine gene expression.
Golden beam data for proton pencil-beam scanning (2012)

Proton, as well as other ion, beams applied by electro-magnetic deflection in pencil-beam scanning (PBS) are minimally perturbed and thus can be quantified a priori by their fundamental interactions in a medium. This a priori quantification permits an optimal reduction of characterizing measurements on a particular PBS delivery system. The combination of a priori quantification and measurements will then suffice to fully describe the physical interactions necessary for treatment planning purposes. We consider, for proton beams, these interactions and derive a 'Golden' beam data set. The Golden beam data set quantifies the pristine Bragg peak depth-dose distribution in terms of primary, multiple Coulomb scatter, and secondary, nuclear scatter, components. The set reduces the required measurements on a PBS delivery system to the measurement of energy spread and initial phase space as a function of energy. The depth doses are described in absolute units of Gy(RBE) mm² Gp⁻¹, where Gp equals 10⁹ (giga) protons, thus providing a direct mapping from treatment planning parameters to integrated beam current. We used these Golden beam data on our PBS delivery systems and demonstrated that they yield absolute dosimetry well within clinical tolerance.
A Method to Assess Concomitant Cardiac Phosphodiesterase Inhibition and Positive Inotropy (1987)

The ability of positive inotropic drugs to inhibit phosphodiesterase was assessed by observance of the potentiation of inotropic responses to the low intrinsic efficacy beta-adrenoceptor partial agonist prenalterol. Previous studies have shown that an increase in tissue stimulus response capability, as is produced for beta-adrenoceptors by blockade of phosphodiesterase, produces an increase in the maximal response to beta-adrenoceptor partial agonists. Using this principle, we tested cardiotonic drugs on normal and prenalterol-pretreated guinea pig left atria and compared the resulting inotropic responses statistically. Prenalterol pretreatment did not potentiate inotropic responses to methoxamine and CaCl2 and blocked (in accordance with beta-adrenoceptor occupation by a low-efficacy partial agonist) responses to norepinephrine (NE), tyramine, and to a certain extent ouabain. This latter finding was attributed to a low-level catecholamine-release by ouabain in this tissue. The inotropic responses to the phosphodiesterase inhibitors isobutylmethylxanthine (IBMX), theophylline, and enprophylline were greatly potentiated. Similarly, the responses to the cardiotonic drugs (known also to be inhibitors of phosphodiesterase) milrinone, amrinone, and fenoximone were potentiated. Positive inotropy to the cardiotonic drug sulmazole was not significantly potentiated by this procedure, indicating that in this tissue sulmazole may produce inotropic responses by other mechanisms as well. In general, this simple assay may be useful to detect blockade of cardiac phosphodiesterase concomitant with positive inotropy. Although a causal relationship between the PDE inhibition and positive inotropy may not be made from these data, knowledge of PDE blockade may still be useful in the assessment of inotropic mechanism and propensity for toxic side effects.