gebhart/patrepeval huggingface dataset:
Electrochemistry of NADH/NAD+ analogs. A detailed mechanistic kinetic and thermodynamic analysis of the 10-methylacridan/10-methylacridinium couple in acetonitrile (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemistry of NADH/NAD+ analogs. A detailed mechanistic kinetic and thermodynamic analysis of the 10-methylacridan/10-methylacridinium couple in acetonitrilePhilippe Hapiot, Jacques Moiroux, and Jean Michel SaveantCite this: J. Am. Chem. Soc. 1990, 112, 4, 1337–1343Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/ja00160a007https://doi.org/10.1021/ja00160a007research-articleACS PublicationsRequest reuse permissionsArticle Views824Altmetric-Citations103LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On-Line Global Energy Optimization in Multi-Core Systems Using Principles of Analog Computation (2006)

This work presents the design and the silicon implementation of an on-line energy optimizer unit, which is capable of dynamically adjusting power supply voltages and operating frequencies of multiple processing elements. The optimized voltage/frequency assignments are tailored to the instantaneous workload information and fully adaptive to variations in process and temperature. The optimizer unit has a fast response time of 50 mus, occupies a silicon area of 0.021mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> / task and dissipates 2 mW/task
Recognition of indoor images employing qualitative model fitting and supporting relation between objects (2002)

We describe a new design of a recognition system for a single image of indoor scene including complex occlusions. In our system the system first estimates the 3D structure of an object by fitting a 3D structure model to the image qualitatively. Next, by checking the supporting relation between objects, it eliminates object candidates that are impossible to exist and estimates actual objects from their parts in the image. Finally, the system then recognizes the objects that are consistent with each other. We implemented the system as a multi-agent-based image understanding system. This paper describes an outline of the system and results of recognition experiments.
A Model of Internet Consumer Satisfaction: Focusing on the Web-site design (1999)

Since the trend of doing business on line has become more and more common among different sizes of companies and industries, measuring the antecedents of web site design is important to both practitioners and researchers. Achieving customer satisfaction is the ultimate goal of electronic commerce so to guarantee on line purchases. Based on the research models and factors proposed by previous studies on customer satisfaction and Web interface design, a new model is developed in this paper. This model shows how various antecedent factors affect consumer satisfaction towards Internet shopping through the intermediate construct of a successful Web- site design.
Cogeneration of electric power and nitric oxide in a solid-electrolyte fuel cell (1984)

Postoperative nasal packing aggravated measures of OSA in patients with mild OSA but not in patients with moderate/severe OSA.
The North American Immune Tolerance Registry: contributions to the thirty‐year experience with immune tolerance therapy (2009)

The North American Immune Tolerance Registry (NAITR) began in 1992 as a project of the ISTH Factor VIII/IX Subcommittee with the goal of further determining immune tolerance induction (ITI) practices in Canada and the United States. This retrospective registry study, published in 2002, was limited in its capacity to provide definitive answers to many unresolved ITI practice issues. Nonetheless, it played a role in developing guidelines for current ITI practice and in generating hypotheses that must now be examined through rigorous prospective data collection efforts. For haemophilia A, the logical next step has been the initiation of international prospective randomized studies of ITI outcome relative to factor VIII (FVIII) dose and purity for subjects with high titre inhibitors. Both trials will additionally provide platforms for translational study of the immunology of tolerance, a prelude to the next generation of safe and effective tolerizing strategies. For the less common problem of FIX inhibitor eradication, prospective randomized studies will not be a feasible way to confirm the NAITR observations. Coordinated international efforts will still be required to prospectively collect data on ITI outcome to document new potentially effective therapeutic strategies for inhibitor eradication. These registries will hopefully also serve to identify potential subjects for scientific studies of immunology of haemophilia B-related allergic phenomena, a devastating complication of FIX antibody development.
Factors Persuading ICTs Use among University Students in Africa and Applicability of the UTAUT Model: A Literature Survey (2015)

The preset study was carried out to survey various literatures on the factors influencing the use of Information and Communication Technologies (ICTs) among university students in Africa, and accordingly to investigate the applicability of the Unified Theory of Acceptance and use of Technology (UTAUT) as presented by Venkatesh et al. (2003) on the observed factors.The study was highly qualitative and involved a survey of literatures on researches conducted in various universities found in African countries.The countries which research studies were involved were selected at random.In order to arrive at reasonable conclusion, literature from at least one country from each of the five regions of Africa was involved.Findings revealed that the main reasons for ICTs use among university students in Africa are pedagogical and social; however the later are subdivided into various reasons.It was further deduced that university students are finding ways for ICTs to smoothen the progress of their academic and social life.These finding agree with the assertion by the UTAUT's first core determinant variables of technology use, the performance expectancy.The study also revealed that the extent of use of ICTs tools and applications by university students in Africa depends on the availability of those tools/applications, which is unlike the effort expectancy as asserted by the UTAUT model.It was also discovered that male students are using ICTs slightly more than females; the main differentiation is however on social reasons than pedagogical reasons, among other findings.In most cases the study agrees with the UTAUT model on the factors persuading ICTs use among university students in Africa except in few cases as presented in the document.
Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. (1982)

1-O-Alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (AAGPC) triggered the release of [3H]arachidonate but not [14C]stearate from cellular phospholipids in cytochalasin B-treated rabbit polymorphonuclear leukocytes. Concentrations of AAGPC up to 20 nM caused a dose-dependent release and subsequent metabolism of the released [3H]arachidonic acid. Most of the release of the [3H]arachidonate had taken place within the first 2 min of stimulation. Phosphatidylinositol and phosphatidylcholine served as the sources of [3H]arachidonate with about 50% of the label coming from each pool. Challenge of cytochalasin B-treated polymorphonuclear leukocytes with AAPGC led to the production of [3H]hydroxyeicosatetraenoic acids and [3H]dihydroxyeicosatetraenoic acids. No significant production of [3H]prostaglandins or [3H]thromboxanes was detected. AAGPC also caused a dose-dependent degranulation of cytochalasin B-treated rabbit polymorphonuclear leukocytes as shown by the release of beta-glucuronidase and lysozyme. Both the AAGPC-stimulated production of arachidonate metabolites and the degranulation response were blocked by eicosatetraynoic acid and non-dihydroguaiaretic acid at similar inhibitor concentrations. These findings suggest the bioactions of AAGPC on polymorphonuclear leukocytes may be mediated by the release of arachidonic acid and the production of mono- and dihydroxyeicosatetraenoic acids.
Structural X-ray Image Segmentation for Threat Detection by Attribute Relational Graph Matching (2005)

This paper addresses part of the problem dealing with the automatic threat detection for accompanied baggage based on multi-energy X-ray imagery for station security. Segmentation is the first significant stage to extract interested objects in the images for detailed analysis and recognition at following stages. In order to obtain the integrated objects for subsequent analysis and recognition, we propose a structural segmentation method based on ARG matching. The proposed segmentation algorithms are a series of graph-matching algorithms based on models under a kind of similarity measure fuzzy similarity distance (FSD) that represents the similarity of the attributed relation between the vertex neighborhood and a certain model. Finally, the number of layer attribute for each region is obtained, and the integrated objects can be extracted using relational attributes and space information. The results show a good average integrity of objects segmented from experimental images
Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes (2014)

Since its first description more than 20 years ago osteopontin has emerged as an active player in many physiological and pathological processes, including biomineralization, tissue remodeling and inflammation. As an extracellular matrix protein and proinflammatory cytokine osteopontin is thought to facilitate the recruitment of monocytes/macrophages and to mediate cytokine secretion in leukocytes. Modulation of immune cell response by osteopontin has been associated with various inflammatory diseases and may play a pivotal role in the development of adipose tissue inflammation and insulin resistance. Here we summarize recent findings on the role of osteopontin in metabolic disorders, particularly focusing on diabetes and obesity.
Nonparametric discovery of activity patterns from video collections (2012)

We propose a nonparametric framework based on the beta process for discovering temporal patterns within a heterogenous video collection. Starting from quantized local motion descriptors, we describe the long-range temporal dynamics of each video via transitions between a set of dynamical behaviors. Bayesian nonparametric statistical methods allow the number of such behaviors and the subset exhibited by each video to be learned without supervision. We extend the earlier beta process HMM in two ways: adding data-driven MCMC moves to improve inference on realistic datasets and allowing global sharing of behavior transition parameters. We illustrate discovery of intuitive and useful dynamical structure, at various temporal scales, from videos of simple exercises, recipe preparation, and Olympic sports. Segmentation and retrieval experiments show the benefits of our nonparametric approach.
Placental Expression of Interferon-γ (IFN-γ) and Its Receptor IFN-γR2 Fail to Switch from Early Hypoxic to Late Normotensive Development in Preeclampsia (2005)

The inability of the mother to switch from T helper cell type 1 (Th1) to Th2 cytokine profiles at the fetal-maternal interface has been proposed as one of the primary causes of miscarriage, intrauterine growth restriction (IUGR), and preeclampsia (PE). The Th1 [interferon-gamma (IFN-gamma), TNF-alpha, and IL-12] and Th2 (IL-4 and IL-10) cytokines have opposite effects on human pregnancy. Leukemia inhibitory factor (LIF) promotes embryo implantation and sustains pregnancy, whereas IFN-gamma and TNF-alpha are detrimental to pregnancy. Both IFN-gamma and LIF are produced by maternal cells and tissues at the fetal-maternal interface, whereas the IFN-gamma receptors (IFN-gamma R1 and IFN-gamma R2) and LIF receptor are abundantly expressed on the surface of placental trophoblasts. The effect of IFN-gamma on T lymphocyte activation is influenced by the relative membrane density of its two receptors, particularly IFN-gamma R2. In this study we report that in PE (25-40 wk gestation) and PE complicated by IUGR, IFN-gamma R2 protein expression is severely down-regulated and is similar to that observed in early placenta (7-10 wk gestation) developing under low O(2) tension. IFN-gamma production was found to be inversely related to the IFN-gamma R2 protein expression, and LIF receptor protein expression in PE mimicked that in early placental development. These results show that in PE, placental trophoblasts fail to establish an early to late switch with respect to IFN-gamma and IFN-gamma R2 expression. This supports the hypothesis that trophoblasts control the polarization of maternal immune effectors and cytokine profiles at the fetal-maternal interface that could be subject to oxidative stress in PE.
Reconstituted 3-Dimensional Human Skin as a Novelin VitroModel for Studies of Carcinogenesis (1999)

EpiDerm (MatTek Co., MA) is a reconstituted human skin equivalent which exhibits morphological and growth characteristics similar to human skin. This model has previously been utilized to evaluate the cytotoxicity and irritant potential of various cosmetic and household products. In this study, we show for the first time that EpiDerm can be used successfully to evaluate the genotoxicity of different types of known carcinogenic agents such as benzo[a]pyrene (BaP), ultraviolet B radiation (UVB), ultraviolet A radiation (UVA), and psoralen-ultraviolet A radiation (PUVA) at the molecular level. The topical application of 50 microg/cm2 BaP to EpiDerm resulted in the accumulation of BaP-DNA adducts and c-fos and p53 proteins as evidenced by immunohistochemical localization. Similarly, exposure to UVB (50 mJ/cm2) and UVA (2.5 J/cm2) enhanced the epidermal expression of c-fos and p53 proteins in the human skin equivalent. PUVA treatment of EpiDerm, however, resulted in the formation of both DNA-8-MOP adducts and augmented expression of c-fos and p53 proteins. Most of these changes reached a peak 8 h after the treatments except in the case of UVA where maximum changes in the expression of c-fos and p53 proteins were observed 24 h after treatment. These results are similar to those previously reported in human and murine skin following exposure to BaP, UVB, UVA, or PUVA indicating that human skin equivalents can be used as a convenient and cost-effective alternative to animal testing for assessing the genotoxicity and mechanism of action of mutagens/carcinogens in human skin.
High performance DNA purification using a novel ion exchange matrix. (2008)

Ion exchange chromatography has emerged as a reliable alternative to classic CsCl-ethidium bromide gradients for isolating nucleic acids of the highest purity. A plasmid purification method based on a unique anion exchange membrane (IEXM) was developed for the production of superior quality plasmids. This method was simpler and more efficient than conventional bead-based methods. Plasmids were extracted from bacterial cells through alkaline lysis. The crude lysate was clarified by a sequential filtration device that not only removed cell debris but micellar aggregates as well. The clarified lysate was mixed with an extraction solution and loaded into a spin column containing IEXM. Binding, washing, and elution conditions were optimized to achieve efficient isolation of plasmids from the impurities. IEXM had an exceedingly high dynamic binding capacity, excellent selectivity, and a near 100% recovery for plasmids. The binding capacity for pUC19 was 2.93 mg/cm(3) of IEXM, which is several times greater than the values for conventional ion exchange beads. The superior selectivity of the method was reflected in the extremely low levels of endotoxin, and thus it is well-suited for critical applications in eukaryotic systems.
Short-Term Load Forecasting: Similar Day-Based Wavelet Neural Networks (2009)

In deregulated electricity markets, short-term load forecasting is important for reliable power system operation, and also significantly affects markets and their participants. Effective forecasting, however, is difficult in view of the complicated effects on load by a variety of factors. This paper presents a similar day-based wavelet neural network method to forecast tomorrow's load. The idea is to select similar day load as the input load based on correlation analysis, and use wavelet decomposition and separate neural networks to capture the features of load at low and high frequencies. Despite of its "noisy" nature, high frequency load is well predicted by including precipitation and high frequency component of similar day load as inputs. Numerical testing shows that this method provides accurate predictions.
Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells (2012)

We demonstrated previously that the activation of ALK7 (activin receptor-like kinase-7), a member of the type I receptor serine/threonine kinases of the TGF-β superfamily, resulted in increased apoptosis and reduced proliferation through suppression of Akt signaling and the activation of Smad2-dependent signaling pathway in pancreatic β-cells. Here, we show that Nodal activates ALK7 signaling and regulates β-cell apoptosis. We detected Nodal expression in the clonal β-cell lines and rodent islet β-cells. Induction of β-cell apoptosis by treatment with high glucose, palmitate, or cytokines significantly increased Nodal expression in clonal INS-1 β-cells and isolated rat islets. The stimuli induced upregulation of Nodal expression levels were associated with elevation of ALK7 protein and enhanced phosphorylated Smad3 protein. Nodal treatment or overexpression of Nodal dose- or time-dependently increased active caspase-3 levels in INS-1 cells. Nodal-induced apoptosis was associated with decreased Akt phosphorylation and reduced expression level of X-linked inhibitor of apoptosis (XIAP). Remarkably, overexpression of XIAP or constitutively active Akt, or ablation of Smad2/3 activity partially blocked Nodal-induced apoptosis. Furthermore, siRNA-mediated ALK7 knockdown significantly attenuated Nodal-induced apoptosis of INS-1 cells. We suggest that Nodal-induced apoptosis in β-cells is mediated through ALK7 signaling involving the activation of Smad2/3-caspase-3 and the suppression of Akt and XIAP pathways and that Nodal may exert its biological effects on the modulation of β-cell survival and β-cell mass in an autocrine fashion.
Quadrifilar Helical Antenna Array for Line-of-Sight Communications Above the Ocean Surface (2007)

This report describes the development of a linear array consisting of four quadrifilar helical antennas (QHAs) that is mounted on a buoy to support transmit and receive communications at 2.45 GHz along line-of-sight (LOS) paths above a sea water half-space. The array elements are designed to be immune to the multipath interference created by reflections of an incident signal from the surface of the ocean. A novel feed design for the array is described. The circuit and radiation characteristics of each QHA element measured in free space are presented. The predicted radiation pattern of each QHA element at its nominal height above a flat ocean surface is determined from the measured element pattern in free space.
3D Graphene Encapsulated Hollow CoSnO<sub>3</sub> Nanoboxes as a High Initial Coulombic Efficiency and Lithium Storage Capacity Anode (2017)

3D Graphene sheets encapsulated amorphous hollow CoSnO<sub>3</sub> nanoboxes (H-CoSnO<sub>3</sub> @reduced graphene oxide [RGO]) are successfully fabricated by first preparing 3D graphene oxides encapsulated solid CoSn(OH)<sub>6</sub> nanocubes, followed by an alkaline etching process and subsequent heating treatment in Ar. The hollow CoSnO<sub>3</sub> nanoboxes with average particle size of 230 nm are uniformly and tightly encapsulated by RGO sheets. As an anode material for Li-ion batteries, H-CoSnO<sub>3</sub> @RGO displays high initial Coulombic efficiency of 87.1% and large reversible capacity of 1919 mA h g<sup>-1</sup> after 500 cycles at the current density of 500 mA g<sup>-1</sup> . Moreover, excellent rate capability (1250, 1188, 1141, 1115, 1086, 952, 736, and 528 mA h g<sup>-1</sup> at 100, 200, 300, 400, 500, 1000, 2000, and 5000 mA g<sup>-1</sup> , respectively) is acquired. The reasons for excellent lithium storage properties of H-CoSnO<sub>3</sub> @RGO are discussed in detail.