gebhart/patrepeval huggingface dataset:
A performance evaluation framework for video streaming (2012)

In this paper, we present a generic framework for performance evaluation of video streams. We embrace the perspective of a streaming application, and model the playback buffer level at given network and playback conditions. That way, our model enables flexible, adaptable evaluation of a wide variety of streaming methods and protocols. We test our model on HTML5 and Flash video as served by the YouTube web site. We find universal achievable limits in any streaming process, and explore quality trade-offs every application has to decide on.
Selective inhibition of vagal afferent nerve pathways regulating cough using Na<sub>v</sub> 1.7 shRNA silencing in guinea pig nodose ganglia (2013)

Adeno-associated virus delivery systems and short hairpin RNA (shRNA) were used to selectively silence the voltage-gated sodium channel NaV 1.7 in the nodose ganglia of guinea pigs. The cough reflex in these animals was subsequently assessed. NaV 1.7 shRNA was delivered to the majority of nodose ganglia neurons [50-60% transfection rate determined by green fluorescent protein (GFP) gene cotransfection] and action potential conduction in the nodose vagal nerve fibers, as evaluated using an extracellular recording technique, was markedly and significantly reduced. By contrast, <5% of neurons in the jugular vagal ganglia neurons were transfected, and action potential conduction in the jugular vagal nerve fibers was unchanged. The control virus (with GFP expression) was without effect on action potential discharge and conduction in either ganglia. In vivo, NaV 1.7 silencing in the nodose ganglia nearly abolished cough evoked by mechanically probing the tracheal mucosa in anesthetized guinea pigs. Stimuli such as capsaicin and bradykinin that are known to stimulate both nodose and jugular C-fibers evoked coughing in conscious animals was unaffected by NaV 1.7 silencing in the nodose ganglia. Nodose C-fiber selective stimuli including adenosine, 2-methyl-5-HT, and ATP all failed to evoke coughing upon aerosol challenge. These results indicate that cough is independently regulated by two vagal afferent nerve subtypes in guinea pigs, with nodose Aδ fibers regulating cough evoked mechanically from the trachea and bradykinin- and capsaicin-evoked cough regulated by C-fibers arising from the jugular ganglia.
A nonconserved Ala401 in the yeast Rsp5 ubiquitin ligase is involved in degradation of Gap1 permease and stress-induced abnormal proteins (2003)

A toxic l-proline analogue, l-azetidine-2-carboxylic acid (AZC), causes misfolding of the proteins into which it is incorporated competitively with l-proline, thereby inhibiting the growth of the cells. AZC enters budding yeast Saccharomyces cerevisiae cells primarily through the general amino acid permease Gap1, not through the proline-specific permease Put4. We isolated an AZC-hypersensitive mutant that cannot grow even at low concentrations of AZC because of the accumulation of intracellular AZC. By screening through a yeast genomic library, the mutant was found to carry an allele of RSP5 encoding an E3 ubiquitin ligase. A single amino acid change replacing Ala (GCA) at position 401 with Glu (GAA) showed that Ala-401 in the third WW domain (a protein interaction module) is not conserved in the domain. The addition of NH4+ to yeast cells growing on l-proline induced rapid ubiquitination, endocytosis, and vacuolar degradation of the plasma membrane protein Gap1. However, immunoblot and permease assays indicated that Gap1 in the rsp5 mutant remained stable and active on the plasma membrane probably with no ubiquitination, leading to AZC accumulation and hypersensitivity. The rsp5 mutants also showed hypersensitivity to various stresses (toxic amino acid analogues, high temperature in a rich medium, and oxidative treatments) and defects in spore growth. These results suggest that Rsp5 is involved in selective degradation of abnormal proteins and specific proteins for spore growth, in addition to nitrogen-regulated degradation of Gap1. Furthermore, Ala-401 of Rsp5 was considered to have an important role in the ubiquitination of targeted proteins.
Serum Linoleic Acid Status as a Clinical Indicator of Essential Fatty Acid Status in Children With Cystic Fibrosis (2008)

Serum phospholipid linoleic acid at 21 mol% or higher was associated with better growth, body composition, and FEV1. No clinical outcome associations were found with the triene:tetraene ratio. These findings suggest that linoleic acid concentration was a more clinically relevant biomarker of EFA status than the triene:tetraene ratio in children with CF and PI. Further research is warranted to validate this specific percentage of linoleic acid cutoff point as a new recommendation for clinical use.
Stoichiometry of the α9α10 Nicotinic Cholinergic Receptor (2005)

The alpha9 and alpha10 nicotinic cholinergic subunits assemble to form the receptor that mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea. They are the latest vertebrate nicotinic cholinergic receptor (nAChR) subunits that have been cloned, and their identification has established a distant early divergent branch within the nAChR gene family. The alpha10 subunit serves as a "structural" component leading to heteromeric alpha9alpha10 nAChRs with distinct properties. We now have probed the stoichiometry of recombinant alpha9alpha10 nAChRs expressed in Xenopus oocytes. We have made use of the analysis of the population of receptors assembled from a wild-type subunit and its partner alpha9 or alpha10 subunit bearing a reporter mutation of a valine to threonine at position 13' of the second transmembrane domain (TM2). Because the mutation increased the sensitivity of the receptor for acetylcholine (ACh) but mutations at different subunits were not equivalent, the number of alpha9 and alpha10 subunits could be inferred from the number of components in compound concentration-response curves to ACh. The results were confirmed via the analysis of the effects of a mutation to threonine at position 17' of TM2. Because at this position the mutations at different subunits were equivalent, the stoichiometry was inferred directly from the shifts in the ACh EC50 values. We conclude that the recombinant alpha9alpha10 receptor is a pentamer with a (alpha9)2(alpha10)3 stoichiometry.
Neural networks in detection of coronary artery disease (2003)

The authors describe the use of neural networks to recognize stenosis in patients with arteriographically proven absence or presence of coronary artery disease by analyzing of thallium-201 scintigrams. There are four possible classification categories: normal, stenosis of the nondominant circumflex coronary artery, stenosis of the left anterior descending, or stenosis of the right coronary artery, including the posterior descending. Two different neural network algorithms are applied to the scintigraphic data: the backpropagation method and the Kohonen algorithm. The backpropagation network consists of three layers of neurodes and utilizes the Delta rule as the learning rule. The Kohonen method involves a single layer of neurodes which uses an unsupervised learning rule to cluster the different classes of data. Both networks are trained using 70% of the scintigraphic data, with the remainder of the data used for testing. The results obtained by using backpropagation are fair with an accuracy of 66.6%. The results from the Kohonen algorithm are better, especially in terms of specificities for both abnormal and normal patients.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Receptor-related mechanism of proliferation inhibilion and apoptosis induetion of human tongue squamous cell line Tca8113 by retinoids]. (2005)

Retinoids can suppress the proliferation of and induce apoptosis of Tca8113 cells, the effect of which involves activation of RAR but not RXR. caspase-3 pathway is involved in apoptosis-inducing effects of retinoids.
Scheduling Page Table Walks for Irregular GPU Applications (2018)

Recent studies on commercial hardware demonstrated that irregular GPU applications can bottleneck on virtual-to-physical address translations. In this work, we explore ways to reduce address translation overheads for such applications. We discover that the order of servicing GPU's address translation requests (specifically, page table walks) plays a key role in determining the amount of translation overhead experienced by an application. We find that different SIMD instructions executed by an application require vastly different amounts of work to service their address translation needs, primarily depending upon the number of distinct pages they access. We show that better forward progress is achieved by prioritizing translation requests from the instructions that require less work to service their address translation needs. Further, in the GPU's Single-Instruction-Multiple-Thread (SIMT) execution paradigm, all threads that execute in lockstep (wavefront) need to finish operating on their respective data elements (and thus, finish their address translations) before the execution moves ahead. Thus, batching walk requests originating from the same SIMD instruction could reduce unnecessary stalls. We demonstrate that the reordering of translation requests based on the above principles improves the performance of several irregular GPU applications by 30% on average.
Continuous Noninvasive Tissue Oximetry in the Early Evaluation of the Combat Casualty: A Prospective Study (2010)

NIRS-derived StO2 obtained on arrival predicts the need for blood transfusion in casualties who initially seem to be hemodynamically stable (SBP >90). Further study of this technology for use in the resuscitation of trauma patients is warranted.
Occlusion shadows: using projected light to generate realistic occlusion effects for view-dependent optical see-through displays (2002)

This paper presents projector-based illumination techniques for creating correct occlusion effects for optical see-through setups. We project view-dependent occlusion shadows onto the real surfaces that are located behind virtual objects. This results in a perfect occlusion of real objects by virtual ones. We have implemented and tested our approach in the context of the Virtual Showcase display. We describe a hardware extension for projecting light into the showcase and present our rendering techniques for displaying occlusion shadows for single and multi-user environments as well as for single and multi-light-projector configurations. We also report on the limitations of our system for multi-user situations and describe our experiences with a first experimental prototype.
Analysis and implementation of a CMOS even harmonic mixer with current reuse for heterodyne/direct conversion receivers (2005)

This paper presents a novel topology for the even harmonic mixer (EHM). The proposed mixer employs a current reuse circuit in the RF input stage to improve its linearity, and uses the double frequency technique in the LO input stage to overcome the leakage and dc offset problems for heterodyne and direct conversion receivers, respectively. In addition, the proposed topology also has the advantages of low power consumption and high conversion gain. In order to demonstrate the benefits of the proposed mixer, theoretical analyses of linearity, conversion gain, and noise performance have been described in detail. The measured results reveal that the proposed mixer has a single-end conversion gain of 9.17 dB, third-order input intercept point (IIP/sub 3/) of -5.01 dBm, and IIP/sub 3//dc of -6.31 dB, under the supply voltage of 1.8 V, power consumption of 1.35 mW, and LO power of 5 dBm at 900 MHz.
Differences between Biopsy‐ or Specimen‐related Laurén andWorld Health Organization Classification in Gastric Cancer (2002)

The extent of stomach resection in gastric cancer depends on tumor size, tumor location, depth of invasion, and the histological allocation to intestinal or diffuse type according to Laurén. As the latter is based on preoperative findings we performed a retrospective histomorphological study to quantify the differences between biopsy-related and surgical specimen-related Laurén classification. Additionally the World Health Organization (WHO) classification of preoperative endoscopic biopsies and surgical specimens were compared. Preoperative biopsies and resected tumor specimens from 100 patients with primary gastric carcinoma were retrospectively classified according toLaurén and WHO. The reclassification was independently performed by three pathologists who were not aware of the previous diagnoses. In 74% the Laurén classification of pre- and postoperative specimens was identical, whereas 26% of the cases showed a disagreement. Out of 48 tumors with preoperative diagnosis of an intestinal type, 10 tumors (20.8%) exhibited a diffuse growth pattern in the gastrectomy specimens; and 16% of the cases showed a disagreement of the pre- and postoperative histopathological type according to the WHO classification. Preoperative biopsy-related and surgical specimen-related Laurén classification differ in about one-quarter of the cases. Mostly, the preoperative diagnosis of an intestinal tumor type must be corrected into a diffuse or mixed type according to Laurén. Since this may have consequences for the surgical strategy, the extent of surgical resection, rebiopsies, and reconfirmation of an intestinal type should be performed at least in those cases with any doubts of this classification.
Complement in the Pathophysiology of Human Disease (1987)

ALMOST exactly 100 years ago it was noted that certain types of bacteria sensitized with specific antibody would lyse in fresh normal serum.1 That observation led to the discovery of the proteins that constitute the complement system. It is now clear that those proteins not only act to lyse target cells, but also have a broad role in the development of the inflammatory response.Complement activity results from the sequential interaction of a large number of plasma and cell-membrane interactive proteins — the complement system — whose number is now thought to approach 25. There is now a considerable body . . .
Synthesis and effects on arginase and nitric oxide synthase of two novel analogues of N<sup>ω</sup>-hydroxyarginine, N<sup>ω</sup>-hydroxyindospicine and p-hydroxyamidinophenylalanine (1996)

Two novel amino acids, Nω-hydroxy-D,L-indospicine and p-hydroxyamidino-D,L-phenylalanine, have been synthesized in four steps from tert-butoxycarbonylglycine. Both compounds act as good inhibitors of arginase, Nω-hydroxyindospicine being one of the best inhibitors of this enzyme known so far (IC50= 50 µmol dm–3). In contrast, with brain NO synthase the two compounds are almost without effect.
Protein-protein interactions in GCR1 signalling in Arabidopsis thaliana (2008)

The G-protein coupled receptors (GPCRs) are seven-transmembrane receptors that transduce signals from the cell surface to intracellular effectors. There are more than 1000 GPCRs in metazoans, while no GPCR has been definitively identified in plants. The most promising plant GPCR candidate, Arabidopsis G-protein coupled receptor 1 (GCR1), physically couples to the G-protein < subunit GPA1 and is involved in cell cycle regulation, blue light and phytohormone responses, but its signalling network remains largely unknown. This project aimed to achieve a better understanding of GCR1 signalling by identifying its interactors using a novel yeast two hybrid system – the Ras Recruitment System (RRS). Screening of an Arabidopsis cDNA library using a bait comprising intracellular loop 1 (i1) and 2 (i2) of GCR1 resulted in the isolation of 20 potential interactors. Extensive reconfirmation screening demonstrated that three of these interactors: Thioredoxin h3 (TRX3), Thioredoxin h4 (TRX4) and a DHHC type zinc finger family protein (zf-DHHC1) interact specifically with both i1 and i2 of GCR1. This was supported by the reverse RRS (rRRS) and 6xHis-pull-down assays. It is speculated that TRX3 and TRX4, which can reduce disulfide bridges of target proteins and act as powerful antioxidants, may regulate GCR1-mediated signalling events in response to oxidative stress. Alternatively, they may modulate GCR1 targeting or signalling through their chaperone activities. zf-DHHC1 has a predicted membrane topography that is shared by most DHHC domain-containing palmitoyl acyl transferases. It may modify GCR1 activity through palmitoylation of the two cysteines located at the cytoplasmic end of the first transmembrane domain. Together, these findings contribute to the growing understanding of the GCR1 signalling network, and provide valuable starting points for further investigation.
Characteristics of the Pseudomonas aeruginosa PA01 intercellular signaling pathway (Quorum Sensing) functioning in presence of porphyrins bismuth complexes (2015)

The influence of synthetic and natural porphyrins bismuth complexes on P. aeruginosa quorum sensing system was carried out by detection of the pyocyanin, rhamnolipids and autoinducers biosynthesis level. The highest ability to reduce pyocyanin biosynthesis showed Bi(III)-TPP. Rhamnolipids production level also decreased in the presence of studied compounds. This effect was the most expressed in presence of 40 and 80 µM of the synthetic meso-substituted porphyrins. Autoinducers biosynthesis, especially 3-oxo-C12-HSL was suppressed in presence of the bismuth complexes. That suggest that the mechanisms of action of this substances is an inhibition of signaling molecules or/and receptor for them.
Basic concepts of orbiting reflectors. (1968)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Practical Nb&lt;inf&gt;3&lt;/inf&gt;Al wires: Experimental behaviour of small scale solenoids (1979)

A number of preceding papers showed the practical possibility of realizing copper stabilized Nb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Al wires, both in mono and multifilamentary configuration. Results are now presented concerning the experimental behaviour of small scale solenoids made by the wind and react method. Details of the construction technique are given in the following. A comparison between short sample characteristics and the experimental results of the small scale solenoids has been made. As a general result a reliable performance of these solenoids has been obtained, thus giving reasonable confidence on larger scale magnets based on this A-15 material.
Natural Melanogenesis Stimulator a Potential Tool for the Treatment of Hypopigmentation Disease (2017)

The synthesis of melanin pigments or melanogenesis has many important physiological functions that include photo protection of the human skin from ultraviolet (UV) irradiation.Melanogenesis is a complex pathway involving melanin synthesis, melanin transport, and melanosome release.Melanin synthesis is stimulated by various effects such as α-melanocyte-stimulating hormone (α-MSH); cyclic AMP (cAMP) elevating agents including palmitic acid, methyl ester, psoralen, thymoquinone, piperine, berberine and withaferin-A.Loss of the hair shaft melanin is associated with decrease of tyrosinase activity in the bulb of melanocytes.Activators of tyrosinase with stimulatory effects on melanogenesis are beneficial for the treatment of hypopigmentation diseases.This is only report authors found in literature about tyrosinase activation.Melanogenesis stimulator are rarely studied as most industries are more interested on inhibitors of the enzyme in order to reduce the adverse effects of melanin formation in, for example, processed food and human skin.Hence, there is a need to review the successful utilization of tyrosinase stimulators from natural herbs for medicinal applications.
Using CompuServe (1995)

From the Publisher:
This user-friendly reference meets the needs of both new and current CompuServe users by providing the basics on getting started and finding information in CompuServe.
Covers all the new services added in the last 9 months, including new Internet capabilities such as Telnet, the World Wide Web browser, and new Internet forums
Keys into the needs of the new CompuServe user
Provides the reader with money-saving guidance on finding the information they want
Use versus manufacture life cycle energy and environmental impacts for tape drives (2002)

Many companies have focused on pollution prevention initiatives including reducing the amount of energy required in production. However, many products consume orders of magnitude more energy and cause greater environmental emissions over the entire life span. With this in mind, Quantum Corporation's Environmental Stewardship Group recently initiated an evaluation of the differential energy and environmental impacts of its tape drive products shipped worldwide. An interim conclusion is that operating energy levels should be managed to lower the amount of energy consumed over the life of the product. This would serve to reduce the total cost of ownership for Quantum's customers, while at the same time, reducing the global environmental impact of the product.
Volume and rigidity of hyperbolic polyhedral 3‐manifolds (2018)

We investigate the rigidity of hyperbolic cone metrics on 3-manifolds which are isometric gluing of ideal and hyper-ideal tetrahedra in hyperbolic spaces. These metrics will be called ideal and hyper-ideal hyperbolic polyhedral metrics. It is shown that a hyper-ideal hyperbolic polyhedral metric is determined up to isometry by its curvature and a decorated ideal hyperbolic polyhedral metric is determined up to isometry and change of decorations by its curvature. The main tool used in the proof is the Fenchel dual of the volume function.
Efficacy and Safety of a New Intravenous Immunoglobulin in Adult Subjects with Chronic Idiopathic Thrombocytopenic Purpura. (2005)

Abstract Idiopathic thrombocytopenic purpura (ITP) is a common clinical disorder of immune regulation leading to phagocytic destruction of platelets. Intravenous immunoglobulin (IGIV) has been used successfully to increase platelet count in patients with ITP. Baxter has developed a new IGIV (IGIV,10%), a 10% liquid immunoglobulin preparation with 3 dedicated virus reduction steps integrated into the manufacturing process. The efficacy and safety of this product was assessed in a prospective multi-center study in adult chronic ITP patients with platelet counts of 20x109/L or less. A total of 23 subjects were enrolled and treated for 2 to 5 days with a total dose of 2 g/kg. Of 21 subjects included in the per-protocol analysis data set, 15 responded to treatment (71.4%), achieving a platelet count of at least 50x109/L by Day 8. Fourteen of 15 responders reached this level by Day 5. The median duration of platelet response was 25 days and the highest median platelet count in the responders was 182x109/L. A total of 81 infusions were administered to the 23 subjects in the safety analysis data set. Among the 40 non-serious adverse events related to the use of the study drug, 35 were mild, 3 were moderate, and 2 were severe. The most frequent related adverse events were headache and pyrexia. The results of this study demonstrate that IGIV, 10% TVR Solution is effective in the treatment of adult subjects with chronic ITP and has an excellent safety profile.
Strongly phosphorescent platinum(<scp>ii</scp>) complexes supported by tetradentate benzazole-containing ligands (2015)

A family of rigid platinum(<sc>ii</sc>) complexes based on tetradentate benzazole-containing ligands has been prepared as efficient dopants for high performance phosphorescent green/yellow OLEDs.