gebhart/patrepeval huggingface dataset:
Effects of ozone and acidic deposition on carbon allocation and mycorrhizal colonization of Pinus taeda L. seedlings (1991)

Patterns of carbon allocation and mycorrhizal colonization were examined in loblolly pine seedlings from two half-sib families exposed to three ozone treatments (charcoal-filtered air, ambient air + 80 ppb O{sub 3}, and ambient air + 160 ppb O{sub 3}) and three rain pH levels (5.2, 4.5, and 3.3) for 12 weeks in open-topped chambers in a field setting. No statistically significant effects of ozone or rain pH were detected on biomass, root:shoot ratios, or carbon allocation; some consistent patterns were observed, however. Coarse root starch concentrations and mycorrhizal infection varied significantly with ozone levels. No significant interactions of ozone, rain pH, or genotype were detected.
Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma (1998)

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) is a key molecule in intracellular signal transducing pathways that transport extracellular stimuli from cell surface to nuclei. MAPK/ERK has been revealed to be involved in the physiological proliferation of mammalian cells and also to potentiate them to transform. However, its role in the outgrowth of human hepatocellular carcinoma (HCC) has yet to be clarified. Therefore, in this study, we investigated the activation of MAPK/ERK and its associated gene expression in HCC. MAPK/ERK was activated in 15 of 26 cases of HCC we examined (58%), and its activity level was significantly higher in HCC than in the adjacent non-cancerous lesions. Besides, MAPK/ERK activation in HCC was positively correlated with protein expression of transcription factor c-Fos. Furthermore, in 25 of 26 cases of HCC which genomic DNA was available, 22 cases without genomic DNA amplification exhibited positive correlation, not only between protein expression of c-Fos and cyclin D1, but also between MAPK/ERK activation and cyclin D1 expression. Concerning the relationship between MAPK/ERK activation and the clinicohistopathological features of HCC, the tumor (HCC) versus non-tumor (non-cancerous counterpart) ratio (T/N) of MAPK/ERK activity was positively correlated with tumor size, but neither with the stage of HCC nor the degree of differentiation of HCC. In conclusion, these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis, especially in the progression of HCC; at least in part, through cyclin D1 up-regulation primarily induced by MAPK/ERK via c-Fos.
Design and Implementation of Mixing Chambers to Improve Thermal Decomposition of Urea for NO <sub>X</sub> Abatement (2012)

Urea-selective catalytic reduction (SCR) has been reported as the most promising technique for adherence to NOX emissions regulations. In the urea-SCR process, NH3 is generated by urea thermal decomposition and hydrolysis and is then used as a reductant of NOX in the SCR catalyst. Therefore, improving the NOX conversion efficiency of urea-SCR requires enhancement of thermal decomposition upstream of the SCR catalyst. In the present work, two types of mixing chambers were designed and fabricated to improve urea thermal decomposition, and experiments with and without a mixing chamber were carried out to analyze thermal-decomposition characteristics of urea in the exhaust pipe with respect to inlet velocity (4–12 m/s) and temperature (350°C–500°C). Urea thermal decomposition is greatly enhanced at higher gas temperatures. At an inlet velocity of 6 m/s in the A-type mixing chamber, NH3 concentrations generated along the exhaust pipe were about 171% and 157% greater than those without the mixing chamber for inlet temperatures of 400°C and 500°C, respectively. In the case of the B-type mixing chamber, NH3 concentrations generated at inlet temperatures of 400°C and 500°C were about 147% and 179% greater than those without the mixing chamber, respectively. Note that the implementation of mixing chambers significantly enhanced conversion of urea to NH3 because it increased the residence time of urea in the exhaust pipe and improved mixing between urea and exhaust gas.
Traffic Sensitive Active Queue Management for Improved Quality of Service (2002)

The Internet, traditionally FTP, e-mail and Web traffic, is increasingly supporting emerging applications such as IP telephony, video conferencing and online games. These new genres of applications have different requirements in terms of throughput and delay than traditional applications. For example, interactive multimedia applications, unlike traditional applications, have more stringent delay constraints and less stringent loss constraints. Unfortunately, the current Internet offers a monolithic best-effort service to all applications without considering their specific requirements. Adaptive RED (ARED) is an Active Queue Management (AQM) technique, which optimizes the router for throughput. Throughput optimization provides acceptable QoS for traditional throughput sensitive applications, but is unfair for these new delay sensitive applications. While previous work has used different classes of QoS at the router to accommodate applications with varying requirements, thus far all have provided just 2 or 3 classes of service for applications to choose from. We propose two AQM mechanisms to optimize router for better overall QoS. Our first mechanism, RED-Worcester, is a simple extension to ARED in order to tune ARED for better average QoS support. Our second mechanism, REDBoston, further extends RED-Worcester to improve the QoS for all flows. Unlike earlier approaches, we do not predefine classes of service, but instead provide a continuum from which applications can choose. We evaluate our approach using NS-2 and present results showing the amount of improvement in QoS achieved by our mechanisms over ARED.
Synthesis of a series of boronated unnatural cyclic amino acids as potential boron neutron capture therapy agents (2008)

Abstract New boronated unnatural cyclic amino acids, 1 – 6 , were synthesized for potential use in neutron capture therapy. In order to understand the effect of molecular lipophilicity on the biological activity, different linkers were introduced between the boronic acid and 1‐aminocycloalkanecarboxylic acid moieties. The key step in the syntheses was the preparation of a series of alkenyl‐substituted cycloalkanones, which were subsequently converted to amino acids via the Bücherer–Strecker reaction. The introduction of the boronic acid function into hydrantoins 19 – 24 was realized by hydroboration reactions using diisopinocampheylborane (Ipc 2 BH). The target boronated amino acids were modeled after 1‐aminocyclobutanecarboxylic acid and 1‐amino‐3‐boronocyclopentanecarboxylic acid, which have previously demonstrated high uptake in tumors. Copyright © 2008 John Wiley & Sons, Ltd.
Nerve growth factor eye drops to treat glaucoma (2010)

Since the discovery of nerve growth factor (NGF) in the 1950s, scientists have had great expectations for NGF in the treatment of neurodegenerative diseases. The main obstacle to overcome was the blood-brain barrier, which NGF does not cross when administered systemically. Our research group has recently demonstrated that topically instilled NGF eye drops are effective in treating several ocular diseases such as neurotrophic and autoimmune corneal ulcers. Pharmacodynamic studies have also shown that NGF eye drops have the ability to target the optic nerve and brain, thus finally opening-up avenues of research in pursuit of a novel drug for neurodegenerative diseases. In this review, clinical trials of systemically and topically administered NGF are discussed, as well as recent progress in the production of biologically active recombinant human NGF and innovative delivery routes. The pharmacological activity of NGF eye drops in ocular surface, retina and optic nerve diseases are also discussed.
Pharmacokinetics and Anti-Gastric Ulceration Activity of Oral Administration of Aceclofenac and Esomeprazole in Rats (2018)

This study examined the effects of esomeprazole on aceclofenac pharmacokinetics and gastrointestinal complications in rats. Aceclofenac alone, or in combination with esomeprazole, was orally administered to male Sprague-Dawley rats. Plasma concentrations of aceclofenac, its major metabolite diclofenac, and esomeprazole were simultaneously determined by a novel liquid chromatography-tandem mass spectrometry method. Gastrointestinal damage was determined by measuring ulcer area and ulcer lesion index of the stomach. Oral administration of aceclofenac induced significant gastric ulceration, which was inhibited by esomeprazole administration. Following concurrent administration of aceclofenac and esomeprazole, overall pharmacokinetic profiles of aceclofenac and metabolic conversion to diclofenac were unaffected by esomeprazole. Aceclofenac metabolism and pharmacokinetics were not subject to significant food effects, whereas bioavailability of esomeprazole decreased in fed compared to fasting conditions. In contrast, the pharmacokinetics of aceclofenac and esomeprazole were significantly altered by different dosing vehicles. These results suggest that co-administration of esomeprazole with aceclofenac may reduce aceclofenac-induced gastrointestinal complications without significant pharmacokinetic interactions. The optimal combination and clinical significance of the benefits of the combination of aceclofenac and esomeprazole need to be further evaluated.
The Sense of Smell in the Neuroses and Psychoses* (1932)

(1932). The Sense of Smell in the Neuroses and Psychoses* The Psychoanalytic Quarterly: Vol. 1, No. 1, pp. 7-42.
Inhibition of Insulin Secretion as a New Drug Target in the Treatment of Metabolic Disorders (2004)

The pattern of insulin release is crucial for regulation of glucose and lipid haemostasis. Deficient insulin release causes hyperglycemia and diabetes, whereas excessive insulin release can give rise to serious metabolic disorders, such as nesidioblastosis (Persistent Hyperinsulinemic Hypoglycemia of Infancy, PHHI) and might also be closely associated with development of type 2 diabetes and obesity. Type 2 diabetes is characterized by fasting hyperinsulinemia, insulin resistance and impaired insulin release, i.e. reduced first phase insulin release and decreased insulin pulse mass. The beta cell function of patients with type 2 diabetes slowly declines and will ultimately result in beta cell failure and increasing degrees of hyperglycemia. Type 2 diabetes, in combination with obesity and cardiovascular disorders, forms the metabolic syndrome. It has been possible to improve beta cell function and viability in preclinical models of type 1 and type 2 diabetes by reducing insulin secretion to induce beta cell rest. Clinical studies have furthermore indicated that inhibitors of insulin release will be of benefit in treatment or prevention of diabetes and obesity. Pancreatic beta cells secrete insulin in response to increased metabolism and by stimulation of different receptors. The energy status of the beta cell controls insulin release via regulation of open probability of the ATP sensitive potassium (K(ATP)) channels to affect membrane potential and the intracellular calcium concentration [Ca(2+)](i). Other membrane bound receptors and ion channels and intracellular targets that modulate [Ca(2+)](i)will affect insulin release. Thus, insulin release is regulated by e.g. somatostatin receptors, GLP-1 receptors, muscarinic receptors, cholecystokinin receptors and adrenergic receptors. Although the relationship between hyperinsulinemia and certain metabolic diseases has been known for decades, only a few inhibitors of insulin release have been characterized in vitro and in vivo. These include the K(ATP) channel openers diazoxide and NN414 and the somatostatin receptor agonist octreotide.
Native Human Serum Amyloid P Component is a Single Pentamer (1995)

Serum amyloid P component (SAP) and C-reactive protein (CRP) are members of the pentraxin protein family. SAP is the precursor protein to amyloid P component present in all forms of amyloidosis. The prevailing notion is that SAP in circulation has the form of a double pentameric molecule (decamer) whereas CRP is a single pentameric molecule. We have investigated by gel permeation chromatography the M(r) of SAP in freshly collected human serum and of SAP purified by carbohydrate affinity chromatography and anion exchange chromatography. SAP was monitored by quantitative immunoelectrophoresis and ELISA, and SAP peak fractions were analysed by use of SDS-PAGE, Western blotting, and electron microscopy. The results indicate that native SAP circulates as a single pentamer, a part of which forms complexes with C4b-binding protein. The properties of SAP changed during purification as indicated by rocket immunoelectrophoresis and electron microscopy. Thus, electron micrographs of purified SAP showed a predominance of decamers. However, the decamer form of SAP reversed to single pentamers when purified SAP was incorporated into SAP-depleted serum.
Expression of platelet glycoproteins by erythroid blasts in four cases of trisomy 21. (1989)

In four patients with trisomy 21 (three constitutional, one acquired) with a morphological undifferentiated leukemia, diagnosis of erythroid leukemia was established by both immunophenotyping and ultrastructural studies. Indeed, a majority of blasts from three patients expressed several erythroid markers such as carbonic anhydrase 1, spectrin beta chain, and glycophorin A. In addition, band 3 and hemoglobin were immunologically detected in a fraction of the blast cells from two cases. At ultrastructural level, a majority or all blast cells exhibited erythroid differentiation features such as theta granules and ferritin molecules. However, platelet glycoproteins GP Ib, GP IIb, and GP IIIa were also immunologically detected in a fraction (from 14-82%) of the blasts. Since the ultrastructural study indicated that some promegakaryoblasts were also present in three patients, double labeling between erythroid markers (glycophorin A or carbonic anhydrase I) and platelet glycoprotein (Ib or IIIa) was performed and showed a clear overlap between the two kinds of markers. A similar approach was performed at ultrastructural level and indicated that blast cells with ultrastructural erythroid features of differentiation may have three distinct phenotypes, i.e., presence of glycophorin A without platelet glycoproteins or, conversely, the presence of platelet glycoproteins without glycophorin A and coexpression of glycophorin A and platelet glycoproteins. Expression of glycophorin A correlated directly with the differentiation level of the erythroid blasts, whereas platelet glycoproteins were essentially expressed in the more primitive leukemic erythroid cells. The GP Ib synthesized by these blasts was subsequently studied. The GP Ib alpha mRNA analyzed by Northern blot from these erythroid cells was identical in size with that from megakaryocytic cells as was the molecular weight of the GP Ib molecule from both after immunoprecipitation by a monoclonal antibody. Therefore, "in vivo" erythroid leukemic cells may express the main platelet glycoproteins including GP Ib.
Coloring based IP Flow Performance Measurement Framework (2013)

draft-chen-ippm-coloring-based-ipfpm-framework-00 By setting one unused bit of the IP header of packets to &quot;color &quot; the packets into different color blocks, it naturally gives a way to measure the real packet loss and delay without inserting any extra OAM packets. This is called &quot;coloring &quot; based IP Flow Performance Measurement (IPFPM). This document specifies a framework for this &quot;coloring &quot; based IPFPM and defines a new application to the IPFIX for exporting the performance measurement statistic data. Requirements Language
Improving writeback efficiency with decoupled last-write prediction (2012)

In modern DDRx memory systems, memory write requests compete with read requests for available memory resources, significantly increasing the average read request service time. Caches are used to mitigate long memory read latency that limits system performance. Dirty blocks in the last-level cache (LLC) that will not be written again before they are evicted will eventually be written back to memory. We refer to these blocks as last-write blocks. In this paper, we propose an LLC writeback technique that improves DRAM efficiency by scheduling predicted last-write blocks early. We propose a low overhead last-write predictor for the LLC. The predicted last-write blocks are made available to the memory controller for scheduling. This technique effectively re-distributes the memory requests and expands writes scheduling opportunities, allowing writes to be serviced efficiently by DRAM. The technique is flexible enough to be applied to any LLC replacement policy. Our evaluation with multi-programmed workloads shows that the technique significantly improves performance by 6.5%-11.4% on average over the traditional writeback technique in an eight-core processor with various DRAM configurations running memory intensive benchmarks.
Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology (2018)

Over the last decades, the concept of precision medicine has dramatically renewed the field of medical oncology; the introduction of patient-tailored therapies has significantly improved all measurable outcomes. Liquid biopsy is a revolutionary technique that is opening previously unexpected perspectives. It consists of the detection and isolation of circulating tumor cells, circulating tumor DNA and exosomes, as a source of genomic and proteomic information in patients with cancer. Many technical hurdles have been resolved thanks to newly developed techniques and next-generation sequencing analyses, allowing a broad application of liquid biopsy in a wide range of settings. Initially correlated to prognosis, liquid biopsy data are now being studied for cancer diagnosis, hopefully including screenings, and most importantly for the prediction of response or resistance to given treatments. In particular, the identification of specific mutations in target genes can aid in therapeutic decisions, both in the appropriateness of treatment and in the advanced identification of secondary resistance, aiming to early diagnose disease progression. Still application is far from reality but ongoing research is leading the way to a new era in oncology. This review summarizes the main techniques and applications of liquid biopsy in cancer.
Deep-sea Geo-referenced Video Mosaics (2006)

Seafloor imagery is an important tool for scientists engaged in quantifying geological and biological processes operating on the deep-ocean floor. Large-scale mosaics of seafloor imagery have significant advantages over individual still photographs and video footage as they are able to capture large areas while retaining sufficient resolution to identify small-scale features. However, the process of constructing a mosaic is usually limited to a single panorama or transects from still imagery, and often requires manual control by the user. The goal of this paper is to describe a methodology that allows for utilization of navigation data for robust automatic construction and geo-referencing of video mosaics. This methodology is designed specifically for the submersible Alvin, but our methodology may be modified for use with other underwater vehicles and is broadly applicable to the creation of mosaics in a variety of seafloor settings
Synthesis of LiFePO[sub 4] Nanoparticles in Polyol Medium and Their Electrochemical Properties (2006)

nanoparticles were synthesized using the polyol process without any further heating as a postprocessing step. The X-ray diffraction patterns of the sample exhibited a good fit with the orthorhombic phase with no unwanted impurity phases. The nanoparticles showed a reversible capacity of , which amounts to a utilization efficiency of 98%, with an excellent reversibility in extended cycles. The electrode shows an excellent capacity retention at high-rate current densities due to its single-crystal-like and monodispersed uniform morphology with orthorhombic shape with an average width of and length of .
Online collaboration: Scientists and the social network (2014)

Giant academic social networks have taken off to a degree that no one expected even a few years ago. A Nature survey explores why.
Reservoir connectivity: Definitions, strategies, and applications (2008)

Reservoir connectivity and compartmentalization are critical areas of research and business application. A general review of reservoir connectivity reveals significant differences among companies and academics regarding its definition, measurement, modeling and action. However, most agree that connectivity depends on a field’s structural framework, stratigraphy and fluid characteristics. We approach reservoir connectivity by first defining two types: static and dynamic. Static connectivity refers to the original state of a field, prior to production start-up. Evaluation of static connectivity is the basis for proper assessment of original hydrocarbons- in-place and prediction of fluid contacts in untested compartments. Dynamic connectivity describes movement of fluids in response to production. Initiation of production perturbs original fluid distributions, as pressure and saturation changes propagate in a complex fashion across field compartments. Barriers and baffles play varying roles over field life, becoming more-or-less <br>important over time, suggesting that compartment boundary is itself a dynamic designation. Analysis of dynamic connectivity is essential to estimating ultimate recovery. Our technology called reservoir connectivity analysis (RCA) investigates static field compartments and associated connections. We define a static compartment as a trap with no internal boundaries (e.g. faults, channel margins) so that over geologic time, it can develop only one gas-oil and/or one oil-water contact. Connections between compartments include fault juxtaposition windows and erosional scours between channels. Examples of RCA application and its impact on our fields are discussed. In these mature producing fields, RCA has explained production anomalies, generated new drill well opportunities, and boosted field reserves above original estimates.
On-Demand Droplet Spotter for Preparing Pico- to Femtoliter Droplets on Surfaces (2001)

A droplet spotter for on-demand generation of pico- to femtoliter droplets was developed to meet the requirement for high-density spotting of chemicals on a surface. Our droplet spotter involves applying a approximately 1000-V and approximately 10-ms pulse voltage to the tip of a capillary tube (o.d. approximately 18 microns; i.d. approximately 11 microns) supplied with water or a dye solution. The capability of the spotter was demonstrated by preparing a microarray of dye molecules. The microarray was prepared by spotting approximately 30-fL droplets of a dye solution on a surface at the density of one spot per 20 x 20 micron 2.
CORG: a database for COmparative Regulatory Genomics (2003)

Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG-'COmparative Regulatory Genomics'-database. The data were computed based on statistically significant local suboptimal alignments of 15 kb regions upstream of the translation start sites of, currently, 10 793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service (http://corg.molgen.mpg.de) for query and interactive visualization of the conserved blocks and their annotation.