gebhart/patrepeval huggingface dataset:
Review on Technologies used to Design RF Diplexers (2018)

In this review paper, we present the recent progress in the design of RF diplexers. It is known that diplexers play an important role in many modern telecommunication systems. In this context, several types of diplexers have been proposed in literature. This review is particularly interested in working principle and diplexers role in wireless communication systems. It also discusses the main features of a diplexer and a general comparison between the various technologies used to design the diplexer circuits.
Optical design of an hemispherical, long-wave infrared panomorph lens for total situational awareness (2009)

The proliferation of security and surveillance missions in urban environments dictates the greater use of optical systems in situational awareness for ground vehicle protection. The need for total situation awareness requires unique optical based systems combining visible and thermal imaging, advanced image processing, and analytic functionalities. These sensors must provide a full hemispheric field of view with a high refresh rate in low cost and compact packages. This paper describes the design of a fast panomorph lens for the 8-12 μm IR band with hemispheric capabilities in a single integrated package that can be added to actual platforms to enhanced situation awareness systems. The various tradeoffs that were explored are detailed (material, size, relative cost, tolerances, F/#). The advantages and disadvantages of the panomorph design are compared to reflective, diffractive and other refractive solutions.
Very Low Birth Weight Preterm Infants With Surgical Short Bowel Syndrome: Incidence, Morbidity and Mortality, and Growth Outcomes at 18 to 22 Months (2008)

Short bowel syndrome is rare in neonates but has a high mortality rate. At 18 to 22 months' corrected age, extremely low birth weight infants with short bowel syndrome were more likely to have growth failure than infants without short bowel syndrome.
An automatic warning system for epileptic seizures recorded on intracerebral electroencephalograms (2004)

0-494-06554-0 L'auteur a accord une licence non exclusive permettant la Bibliothque et Archives Canada de reproduire, publier, archiver, sauvegarder, conserver, transmettre au public par tlcommunication ou par l'Internet, prter, distribuer et vendre des thses partout dans le monde, des fins commerciales ou autres, sur support microforme, papier, lectronique et/ou autres formats.L'auteur conserve la proprit du droit d'auteur et des droits moraux qui protge cette thse.Ni la thse ni des extraits substantiels de celle-ci ne doivent tre imprims ou autrement reproduits sans son autorisation.Conformment la loi canadienne sur la protection de la vie prive, quelques formulaires secondaires ont t enlevs de cette thse.Bien que ces formulaires aient inclus dans la pagination, il n'y aura aucun contenu manquant.
Purification and Characterization of a Lovastatin Esterase from Clonostachys compactiuscula (1997)

An esterase from the fungus Clonostachys compactiuscula selectively hydrolyzes lovastatin, a clinically useful antihypercholesterolemic agent. Lovastatin or lovastatin-related compounds were required to induce the activity of the lovastatin 8(prm1)-((alpha)-methylbutyryloxy) esterase. The 46-kDa esterase was purified from mycelial extracts by centrifugation and a single anion-exchange chromatographic separation. Maximal lovastatin esterase activity was found at pH 9.0 to 9.6 and at 25 to 30(deg)C. The addition of 5 to 20% methanol resulted in greater lovastatin hydrolysis, while the addition of other solvents (ethanol, isopropanol, butanol, ethyl acetate, isopropyl acetate, or tetrahydrofuran) decreased hydrolysis. Lovastatin was selectively hydrolyzed even in the presence of an excess of simvastatin, another antihypercholesterolemic agent that is structurally very similar to lovastatin. This lovastatin 8(prm1)-((alpha)-methylbutyryloxy) esterase can be used to prepare a core intermediate for the generation of novel antihypercholesterolemic agents or to purify simvastatin prepared by C methylation of the 2(S)-methylbutyryloxy side chain of lovastatin.
Human <i>COL7A1</i> -corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa (2014)

Patients with recessive dystrophic epidermolysis bullosa (RDEB) lack functional type VII collagen owing to mutations in the gene COL7A1 and suffer severe blistering and chronic wounds that ultimately lead to infection and development of lethal squamous cell carcinoma. The discovery of induced pluripotent stem cells (iPSCs) and the ability to edit the genome bring the possibility to provide definitive genetic therapy through corrected autologous tissues. We generated patient-derived COL7A1-corrected epithelial keratinocyte sheets for autologous grafting. We demonstrate the utility of sequential reprogramming and adenovirus-associated viral genome editing to generate corrected iPSC banks. iPSC-derived keratinocytes were produced with minimal heterogeneity, and these cells secreted wild-type type VII collagen, resulting in stratified epidermis in vitro in organotypic cultures and in vivo in mice. Sequencing of corrected cell lines before tissue formation revealed heterogeneity of cancer-predisposing mutations, allowing us to select COL7A1-corrected banks with minimal mutational burden for downstream epidermis production. Our results provide a clinical platform to use iPSCs in the treatment of debilitating genodermatoses, such as RDEB.
Gear Transmission Error Measurement Using Phase Demodulation (1996)

Gear manufacturers in all fields of industry are under increasing pressure to deliver products of high accuracy and which generate ever lower levels of vibration and noise. Over the past decades, transmission error (TE) measurement has become more popular as a means of measurement for research and quality control. However, dedicated measurement systems have often proved incapable of measuring TE under operating conditions. This paper presents an overview of TE measurement techniques and their applications. In addition, an introduction to a versatile and portable method of measurement based on FFT analysis and demodulation is given. This method is easily implemented using current generation FFT analysers or signal analysis software, and is suitable for research, diagnostics, condition monitoring and quality control applications alike.
Hybrid participant embodiments in networked collaborative virtual environments (2002)

The authors present a novel approach to participant embodiment in networked collaborative virtual environments. The embodiment approach integrates live video into 3D objects for a hybrid participant representation. They implemented their ideas in a Networked Collaborative Virtual Environment system, VLNET and investigated network and rendering issues in comparison with virtual human participant embodiment. The paper presents two distinct case studies demonstrating their ideas. The first one is a tele-teaching application, in which they investigate a shared environment with virtual humans and hybrid embodiments. The second one presents a distributed augmented reality application, in which participants share a mixed environment with real and virtual elements.
Albumin-binding superoxide dismutase with a prolonged half-life reduces reperfusion brain injury (1993)

To test the possible involvement of superoxide radicals in the pathogenesis of reperfusion injury, we synthesized a superoxide dismutase (SOD) derivative [poly(styrene-co-maleic acid) butyl ester (SM) covalently linked to SOD] that circulates bound to albumin, has a prolonged in vivo half-life, and accumulates in pH-decreased tissues. The protective effects of SM-SOD on regional cerebral blood flow, intracranial pressure, cardiac index, vascular permeability, and neurological outcome were investigated using a model of global brain ischemia in dogs. Intra-arterial injection of SM-SOD (10 mg/kg) just before reperfusion increased reactive hyperemia (SM-SOD, 160 +/- 36 ml.100 g-1.min-1, means +/- SD, n = 6; control, 100 +/- 34 ml.100 g-1.min-1, n = 6, P = 0.015), ameliorated delayed hypoperfusion (7 h after ischemia: SM-SOD, 40 +/- 14 ml.100 g-1.min-1; control 17 +/- 6 ml.100 g-1.min-1, P = 0.003), vascular permeability, and neurological outcome without affecting the cardiac index. These results indicate that superoxide radicals and/or their metabolite(s) might play a critical role in the pathogenesis of reperfusion injury in the brain.
Stabilization of ferroelectric phase of Hf0.58Zr0.42O2 on NbN at 4 K (2019)

Ferroelectricity in doped and alloyed hafnia thin films has been demonstrated using several different electrodes, with TiN and TaN being most prominent. In this work, we demonstrate ferroelectric Hf0.58Zr0.42O2 thin films with superconducting NbN electrodes at cryogenic temperatures. Demonstration of polarization—electric field [P(E)] response at liquid helium cryogenic temperatures, 4 K, suggests that the polarization is switchable over a wide temperature range after an initial 600 °C anneal. Further, room temperature P(E) and capacitance measurements demonstrate an expected polarization response with wake-up required to reach the steady state. Wake-up cycling at 4 K is observed to have no effect upon the ferroelectric phase suggesting an oxygen vacancy mobility freeze out whereas wake-up cycling at 294 K demonstrates close to a 3× increase in remanent polarization. This integration of a ferroelectric Hf0.58Zr0.42O2 thin film with NbN demonstrates the suitability of a highly scalable ferroelectric in applications for cryogenic technologies.
The inversion algorithm for digital simulation (1997)

The inversion algorithm is an event-driven algorithm, whose performance rivals or exceeds that of levelized compiled code simulation, even at activity rates of 50% or more. The inversion algorithm has several unique features, the most remarkable of which is the size of the run-time code. The basic algorithm can be implemented using no more than a page of run-time code, although in practice, it is more efficient to provide several different variations of the basic algorithm. The run-time code is independent of the circuit under test, so the algorithm can be implemented either as a compiled code or an interpreted simulator with little variation in performance. Because of the small size of the run-time code, the run-time portions of the inversion algorithm can be implemented in assembly language for peak efficiency, and still can be retargeted for new platforms with little effort.
A Model of SIPOS Deposition Based on Infrared Spectroscopic Analysis (1980)

SIPOS deposited rapidly at atmospheric pressure (AP) is different from SIPOS deposited more slowly at low pressure (LP). The transmission infrared spectra of the AP and LP SIPOS films can be different for the same oxygen content. We interpret our infrared data for AP SIPOS in terms of a statistical model for the bonding of silicon and oxygen that predicts less than 1% character [ tetrahedra] for the AP SIPOS. The LP SIPOS films have more character than the AP SIPOS. We believe this arises from the slower deposition rate for LP SIPOS where oxygen can preferentially bond to an already oxygen‐bonded Si. Stress measurements and reactivity to HF for LP SIPOS films correlate with the infrared data and are consistent with our interpretation of the infrared data.
Cytoplasmic Polyadenylation Element (CPE)- and CPE-binding Protein (CPEB)-independent Mechanisms Regulate Early Class Maternal mRNA Translational Activation in Xenopus Oocytes (2004)

Meiotic cell cycle progression during vertebrate oocyte maturation requires the correct temporal translation of maternal mRNAs encoding key regulatory proteins. The mechanism by which specific mRNAs are temporally activated is unknown, although both cytoplasmic polyadenylation elements (CPE) within the 3'-untranslated region (3'-UTR) of mRNAs and the CPE-binding protein (CPEB) have been implicated. We report that in progesterone-stimulated Xenopus oocytes, the early cytoplasmic polyadenylation and translational activation of multiple maternal mRNAs occur in a CPE- and CPEB-independent manner. We demonstrate that polyadenylation response elements, originally identified in the 3'-UTR of the mRNA encoding the Mos proto-oncogene, direct CPE- and CPEB-independent polyadenylation of an early class of Xenopus maternal mRNAs. Our findings refute the hypothesis that CPE sequences alone account for the range of temporal inductions of maternal mRNAs observed during Xenopus oocyte maturation. Rather, our data indicate that the sequential action of distinct 3'-UTR-directed translational control mechanisms coordinates the complex temporal patterns and extent of protein synthesis during vertebrate meiotic cell cycle progression.
<sup>29</sup>Si NMR Study of Structural Ordering in Aluminosilicate Geopolymer Gels (2005)

A systematic series of aluminosilicate geopolymer gels was synthesized and then analyzed using 29Si magic-angle spinning nuclear magnetic resonance (MAS NMR) in combination with Gaussian peak deconvolution to characterize the short-range ordering in terms of T-O-T bonds (where T is Al or Si). The effect of nominal Na2O/(Na2O + K2O) and Si/Al ratios on short-range network ordering was quantified by deconvolution of the 29Si MAS NMR spectra into individual Gaussian peaks representing different Q4(mAl) silicon centers. The deconvolution procedure developed in this work is applicable to other aluminosilicate gel systems. The short-range ordering observed here indicates that Loewenstein's Rule of perfect aluminum avoidance may not apply strictly to geopolymeric gels, although further analyses are required to quantify the degree of aluminum avoidance. Potassium geopolymers appeared to exhibit a more random Si/Al distribution compared to that of mixed-alkali and sodium systems. This work provides a quantitative account of the silicon and aluminum ordering in geopolymers, which is essential for extending our understanding of the mechanical strength, chemical and thermal stability, and fundamental structure of these systems.
An atmospheric pressure waveguide-fed microwave plasma torch: the TIA design (1994)

We report theoretical and experimental investigations of an atmospheric pressure, microwave plasma torch with axial gas injection (torche a injection axiale design). It is a waveguide-based structure comprising both waveguide and coaxial elements serving the purpose of wavemode conversion and impedance-matching. The device includes features common to various waveguide-fed torches disclosed previously by other authors, but not yet modelled. Our paper provides a simple equivalent circuit description of the torch operation that accounts for its impedance-matching, power transfer to plasma and tuning characteristics, as verified experimentally. From the outcome of the model and using our experimental results, we introduce new features in the torch design that enable one to optimize its performance. We also examine ways of simplifying its structure and operation.
<title>Rapid detection of bacteria with miniaturized pyrolysis-gas chromatographic analysis</title> (2002)

Rapid detection and identification of bacteria and other pathogens is important for many civilian and military applications. The profiles of biological markers such as fatty acids can be used to characterize biological samples or to distinguish bacteria at the gram-type, genera, and even species level. Common methods for whole cell bacterial analysis are neither portable nor rapid, requiring lengthy, labor intensive sample preparation and bench-scale instrumentation. These methods chemically derivatize fatty acids to produce more volatile fatty acid methyl esters (FAMEs) that can be separated and analyzed by a gas chromatograph (GC)/mass spectrometer. More recent publications demonstrate decreased sample preparation time with in situ derivatization of whole bacterial samples using pyrolysis/derivatization. Ongoing development of miniaturized pyrolysis/GC instrumentation by this department capitalizes on Sandia advances in the field of microfabricated chemical analysis systems ((mu) ChemLab). Microdevices include rapidly heated stages capable of pyrolysis or sample concentration, gas chromatography columns, and surface acoustic wave (SAW) sensor arrays. We will present results demonstrating the capabilities of these devices toward fulfilling the goal of portable, rapid detection and early warning of the presence of pathogens in air or water.
Selective Serotonin Reuptake Inhibitors Influence Agonist-Induced Platelet Aggregation. Preliminary Results from Comorbidity of Depression and Cardiovascular Disease Study (2008)

Abstract Selective serotonin reuptake inhibitors (SSRI) are a first-line treatment option for depressive illnesses, anxiety and obsessive-compulsive disorders with a favorable risk benefit ratio and side effects. They selectively inhibit neuronal reuptake of serotonin and result in depleted serotonin stores in the dense bodies of platelets. It is hypothesized that depressive illnesses cause platelet activation and endothelial dysfunction, which could be modulated by the use of SSRIs. In order to validate this hypothesis an institutional-based co morbidity of depression and cardiovascular study is undertaken. Patients with depression (n=25) and healthy control (n=25) are recruited in this study. Males and females between the ages of 20 and 65 years meeting the DSM-IV criteria for major depressive disorder served as the inclusion criteria for the study. The exclusion criteria included patients with heart disease, diabetes, lipid disorders, history of smoking, pregnant and lactating women, psychosis, schizoaffective illnesses and presence of other Axis I diagnosis with the exception of generalized anxiety disorder. Blood samples were collected at baseline and then 4 and 8 weeks following treatment with Escitaloprim, an SSRI. Preliminary results from the agonist-induced platelet aggregation showed varying degrees of inhibition of collagen, ADP, arachidonic acid and epinephrine-induced platelet aggregation as shown in the table below. Agonist induced platelet aggregation profile Averaged % aggregation Time Collagen AA ADP Epinephrine Saline Baseline 71.5± 22.4 64.1± 35.1 48.15± 30.9 55.65± 29.2 6.9± 4.5 Week 4 63.4± 19.5 67.1± 25.1 33± 26.7 37.375± 25.8 9.375± 7.8 Week 8 74.7± 21.3 55.71± 36.1 52.4± 31 50.4± 32.3 5± 3.9 While a number of patients showed an inhibition of ADP (2.5μM) and epinephrine (10μg/ml) and collagen (380μg/ml), however, other patients showed an inhibition of collagen-induced platelet aggregation. These results indicate that patients treated with SSRIs may have inhibition of platelet activation and aggregation, which may have an impact in the prevention of atherothrombotic cardiovascular disease. SSRIs might increase the bleeding tendency in some patients by inhibiting platelet aggregation. However, when the SSRIs are given in combination with other drugs patients may have a propensity for bleeding complications due to drug-drug interactions. Further large-scale trials are warranted to validate these results.
Compact optical circulator for optical fiber transmission (1979)

An optical circulator for near IR radiation was developed for optical transmission systems. This circulator consists of a 45 degrees Faraday rotator using a YIG single crystal and two Glan-Taylor prisms. It has four nonre-ciptocai and two reciprocal ports. Using reciprocal ports for bidirectional transmission systems with multi-mode fibers, which do not conserve light polarization, this circulator can receive any polarized light. Insertion losses of 1.5-2.3 dB among four nomeeiproeal ports were obtained at 1.32-microm wavelength. An insertion loss of 0.66 dB was estimated when nonpolarized light is transmitted, using one nonreciprocal and one reciprocal port at. 1.32-microm wavelength.
Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors (2004)

Adult bone marrow-derived cells can participate in muscle regeneration after bone marrow transplantation. In recent studies a single hematopoietic stem cell (HSC) was shown to give rise to cells that not only reconstituted all of the lineages of the blood, but also contributed to mature muscle fibers. However, the relevant HSC derivative with this potential has not yet been definitively identified. Here we use fluorescence-activated cell sorter-based protocols to test distinct hematopoietic fractions and show that only fractions containing c-kit(+) immature myelomonocytic precursors are capable of contributing to muscle fibers after i.m. injection. Although these cells belong to the myeloid lineage, they do not include mature CD11b(+) myelomonocytic cells, such as macrophages. Of the four sources of mature macrophages tested that were derived either from monocytic culture, bone marrow, peripheral blood after granulocyte colony-stimulating factor mobilization, or injured muscle, none contributed to muscle. In addition, after transplantation of bone marrow isolated from CD11b-Cre-transgenic mice into the Cre-reporter strain (Z/EG), no GFP myofibers were detected, demonstrating that macrophages expressing CD11b do not fuse with myofibers. Irrespective of the underlying mechanisms, these data suggest that the HSC derivatives that integrate into regenerating muscle fibers exist in the pool of hematopoietic cells known as myelomonocytic progenitors.
TARM1 Is a Novel Leukocyte Receptor Complex–Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils (2015)

We identified a novel, evolutionarily conserved receptor encoded within the human leukocyte receptor complex and syntenic region of mouse chromosome 7, named T cell-interacting, activating receptor on myeloid cells-1 (TARM1). The transmembrane region of TARM1 contained a conserved arginine residue, consistent with association with a signaling adaptor. TARM1 associated with the ITAM adaptor FcRγ but not with DAP10 or DAP12. In healthy mice, TARM1 is constitutively expressed on the cell surface of mature and immature CD11b(+)Gr-1(+) neutrophils within the bone marrow. Following i.p. LPS treatment or systemic bacterial challenge, TARM1 expression was upregulated by neutrophils and inflammatory monocytes and TARM1(+) cells were rapidly recruited to sites of inflammation. TARM1 expression was also upregulated by bone marrow-derived macrophages and dendritic cells following stimulation with TLR agonists in vitro. Ligation of TARM1 receptor in the presence of TLR ligands, such as LPS, enhanced the secretion of proinflammatory cytokines by macrophages and primary mouse neutrophils, whereas TARM1 stimulation alone had no effect. Finally, an immobilized TARM1-Fc fusion protein suppressed CD4(+) T cell activation and proliferation in vitro. These results suggest that a putative T cell ligand can interact with TARM1 receptor, resulting in bidirectional signaling and raising the T cell activation threshold while costimulating the release of proinflammatory cytokines by macrophages and neutrophils.
A synthesis procedure for brain-state-in-a-box neural networks (1995)

In this paper, some new qualitative properties of discrete-time neural networks based on the "brain-state-in-a-box" model are presented. These properties concern both the characterization of equilibrium points and the global dynamical behavior. Next, the analysis results are used as guidelines in developing an efficient synthesis procedure for networks that function as associative memories. A constrained design algorithm is presented that gives completely stable dynamical neural networks sharing some interesting features. It is guaranteed the absence of nonbinary stable equilibria, that is stable states with nonsaturated components. It is guaranteed that in close proximity (Hamming distance one) of the stored patterns there is no other binary equilibrium point. Moreover, the presented method allows one to optimize a design parameter that controls the size of the attraction basins of the stored vectors and the accuracy needed in a digital realization of the network.