gebhart/patrepeval huggingface dataset:
Quantitative aspects of relationship between glucose 6-phosphate transport and hydrolysis for liver microsomal glucose-6-phosphatase system. Selective thermal inactivation of catalytic component in situ at acid pH. (1976)

Studies of the thermal stability of rat liver glucose-6-phosphatase (EC 3.1.3.9) were carried out to further elevate the proposal that the enzymic activity is the result of the coupling of a glucose-6-P-specific translocase and a nonspecific phosphohydrolase-phosphotransferase. Inactivation was observed when micorsomes were incubated at mild temperatures between pH 6.2 and 5.6. The rate of inactivation increased either with increasing hydrogen ion concentration or temperature. However, no inactivation was seen below 15 degrees in media as low as pH 5 or at neutral pH up to 37 degrees. The thermal stability of the enzyme may be controlled by the physical state of the membrane lipids and the degree of protonation of specific residues in the enzyme protein. Microsomes were exposed to inactivating conditions, and kinetic analyses were made of the glucose-6-P phosphohydrolase activities before and after supplementation to 0.4% sodium taurocholate. The results support the postulate and the kinetic characteristics of a given preparation of intact microsomes are determined by the relative capacities of the transport and catalytic components. Before detergent treatment, inactivation (i.e. a decrease in Vmax) was accompanied by a decrease in Km and a reduction in the fraction of latent activity, whereas only Vmax was depressed in disrupted preparations. The possibility that the inactivating treatments caused concurrent disruption of the microsomal membrane was ruled out. It is concluded that exposures to mild heat in acidic media selectively inactivate the catalytic component of the glucose-6-phosphatase system while preserving an intact permeability barrier and a functional glucose-6-P transport system. Analyses of kinetic data obtained in the present and earlier studies revealed several fundamental mathematical relationships among the kinetic constants describing the glucose-6-P phosphohydrolase activities of intact (i.e. the "system") and disrupted microsomes (i.e. the catalytic component). The quantitative relationships appear to provide a means to calculate a velocity constant (VT) and a half-saturation constant (KT) for glucose-6-P influx. The well documented, differential responses of the rat liver glucose-6-phosphatase system induced by starvation, experimental diabetes, or cortisol administration were analyzed in terms of these relationships. The possible influences of cisternal inorganic phosphate on the apparent kinetic constants of the intact system are discussed.
Detection of influenza B virus in throat swabs using the polymerase chain reaction. (1992)

An assay protocol based on exploiting the polymerase chain reaction (PCR) for the direct detection of influenza B virus in throat swabs is described. By the use of PCR with nested primers, it was possible to detect the virus in throat swabs. Dilution experiments showed that as little as 1 plaque forming unit of virus was sufficient for detecting the HA gene by the PCR. All throat swab samples from which influenza B virus had been isolated by conventional methods were also positive by the PCR method.
ChemInform Abstract: Properties of the Ru(0001)/Ce‐H2 Interface: A Model System for Transition‐Metal/Rare‐Earth Hydride Catalysts. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fundamentals of Quantum Chemistry: Molecular Spectroscopy and Modern Electronic Structure Computations (2001)

I enjoyed reading this book. The message at the publisher's website [2] gives a very good introduction to this book. I copied and pasted the paragraphs here:[...]
Untersuchungen zur Stabilität des Tocopherolgehaltes pflanzlicher Öle (1988)

Abstract Die Tocopherole pflanzlicher Öle werden während der verschiedenen technologischen Behandlungsverfahren der Rohöle zum Teil zerstört. Ein weiterer Abbau kann während der Lagerung der Öle eintreten. Verantwortlich sind hierfür unter anderem Licht, Sauerstoff und Lagertemperatur. Der Einfluß dieser drei Parameter auf den Gesamttocopherolgehalt und den Gehalt einzelner Tocopherole wurde in raffinierten und kaltgepreßten Ölen im Verlauf einer 3monatigen Lagerung untersucht. Die Ergebnisse zeigen, daß eine Kühllagerung wesentlich zur Stabilität beiträgt. in den bei Raumtemperatur gelagerten Proben hatte der Lichteinfluß eine größere Wirkung als de Sauerstoff. α‐Tocopherol erwies sich bei kühler Lagerung stabiler als γ‐Tocopherol; bei Raumtemperatur wurde α‐Tocopherol – prozentual zum Ausgangsgehalt berechnet – stärker abgebaut als γ‐Tocopherol.
Oral administration of a select mixture of Bacillus probiotics generates Tr1 cells in weaned F4ab/acR− pigs challenged with an F4+ ETEC/VTEC/EPEC strain (2015)

Although breeding of F4 receptor - negative (F4R(-)) pigs may prevent post-weaning diarrhea, the underlying immunity is poorly understood. Here, various doses of a Bacillus licheniformis and Bacillus subtilis mixture (BLS-mix) were orally administered to F4ab/acR(-) pigs for 1 week before F4 (K88) - positive ETEC/VTEC/EPEC challenge. Administration of BLS-mix increased the percentage of Foxp3(-)IL-10(+) T cells but not of Foxp3(+)IL-10(+) regulatory T (Treg) cells among peripheral blood CD4(+) T cells. A low dose of BLS-mix feeding resulted in increased the expression of IL-6, TNF-α, IL-10, and the transcription factors Foxp3 and T-bet mRNAs in the jejunum. Administration of either a low or high dose BLS-mix also led to an increase in the percentage of CD4(+)Foxp3(+) Treg cells among intraepithelial lymphocytes and CD4(+)IL-10(+) T cells in the small intestinal Peyer's patches and the lamina propria of F4ab/acR(-) pigs following F4(+) ETEC/VTEC/EPEC challenge. The increased number of IL-10-producing CD4(+) T cells was attributed to an increase in the proportion of Foxp3(-)IL-10(+) Treg cells rather than Foxp3(+)IL-10(+) Treg cells. Our data indicate that oral administration of BLS-mix to newly weaned F4ab/acR(-) pigs ameliorates enteritis in an F4(+) ETEC/VTEC/EPEC model; however, induction of IL-10-producing Foxp3(-) Treg cells by BLS-mix administration cannot account for the protection of newly weaned F4ab/acR(-) pigs from F4(+) ETEC/VTEC/EPEC infection, and that excessive generation of CD4(+)IL-10(+) T cells following consumption of BLS-mix during episodes of intestinal inflammation that is caused by enteric pathogens might prohibit clearance of the pathogen. Select probiotic mixtures may allow for tailoring strategies to prevent infectious diseases.
Retinal NMDA receptor function and expression are altered in a mouse lacking<scp>d</scp>-amino acid oxidase (2013)

D-serine is present in the vertebrate retina and serves as a coagonist for the N-methyl-D-aspartate (NMDA) receptors of ganglion cells. Although the enzyme D-amino acid oxidase (DAO) has been implicated as a pathway for d-serine degradation, its role in the retina has not been established. In this study, we investigated the role of DAO in regulating D-serine levels using a mutant mouse line deficient in DAO (ddY/DAO(-)) and compared these results with their wild-type counterparts (ddY/DAO(+)). Our results show that DAO is functionally present in the mouse retina and normally serves to reduce the background levels of D-serine. The enzymatic activity of DAO was restricted to the inner plexiform layer as determined by histochemical analysis. Using capillary electrophoresis, we showed that mutant mice had much higher levels of D-serine. Whole cell recordings from identified retinal ganglion cells demonstrated that DAO-deficient animals had light-evoked synaptic activity strongly biased toward a high NMDA-to-AMPA receptor ratio. In contrast, recordings from wild-type ganglion cells showed a more balanced ratio between the two receptor subclasses. Immunostaining for AMPA and NMDA receptors was carried out to compare the two receptor ratios by quantitative immunofluorescence. These studies revealed that the mutant mouse had a significantly higher representation of NMDA receptors compared with the wild-type controls. We conclude that 1) DAO is an important regulatory enzyme and normally functions to reduce D-serine levels in the retina, and 2) D-serine levels play a role in the expression of NMDA receptors and the NMDA-to-AMPA receptor ratio.
From the Editorial Board Chair (2015)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
AT2 Receptor Activities and Pathophysiological Implications (2015)

Although angiotensin II subtype-2 receptor (AT2R) was discovered over 2 decades ago, its contribution to physiology and pathophysiology is not fully elucidated. Current knowledge suggests that under normal physiologic conditions, AT2R counterbalances the effects of angiotensin II subtype-1 receptor (AT1R). A major obstacle for AT2R investigations was the lack of specific agonists. Most of the earlier AT2R studies were performed using the peptidic agonist, CG42112A, or the nonpeptidic antagonist PD123319. CGP42112A is nonspecific for AT2R and in higher concentrations can bind to AT1R. Recently, the development of specific nonpeptidic AT2R agonists boosted the efforts in identifying the therapeutic potentials for AT2R stimulation. Unlike AT1R, AT2R is involved in vasodilation by the release of bradykinin and nitric oxide, anti-inflammation, and healing from injury. Interestingly, the vasodilatory effects of AT2R stimulation were not associated with significant reduction in blood pressure. In the kidney, AT2R stimulation produced natriuresis, increased renal blood flow, and reduced tissue inflammation. In animal studies, enhanced AT2R function led to reduction of cardiac inflammation and fibrosis, and reduced the size of the infarcted area. Similarly, AT2R stimulation demonstrated protective effects in vasculature and brain.
Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. (2011)

Among people exposed to major psychological stressors in early life, there are elevated rates of morbidity and mortality from chronic diseases of aging. The most compelling data come from studies of children raised in poverty or maltreated by their parents, who show heightened vulnerability to vascular disease, autoimmune disorders, and premature mortality. These findings raise challenging theoretical questions. How does childhood stress get under the skin, at the molecular level, to affect risk for later diseases? And how does it incubate there, giving rise to diseases several decades later? Here we present a biological embedding model, which attempts to address these questions by synthesizing knowledge across several behavioral and biomedical literatures. This model maintains that childhood stress gets "programmed" into macrophages through epigenetic markings, posttranslational modifications, and tissue remodeling. As a consequence these cells are endowed with proinflammatory tendencies, manifest in exaggerated cytokine responses to challenge and decreased sensitivity to inhibitory hormonal signals. The model goes on to propose that over the life course, these proinflammatory tendencies are exacerbated by behavioral proclivities and hormonal dysregulation, themselves the products of exposure to early stress. Behaviorally, the model posits that childhood stress gives rise to excessive threat vigilance, mistrust of others, poor social relationships, impaired self-regulation, and unhealthy lifestyle choices. Hormonally, early stress confers altered patterns of endocrine and autonomic discharge. This milieu amplifies the proinflammatory environment already instantiated by macrophages. Acting in concert with other exposures and genetic liabilities, the resulting inflammation drives forward pathogenic mechanisms that ultimately foster chronic disease.
Platelet GP Ib-IX-V: not just a binding protein (2004)

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

While it is now well accepted that platelet adhesion and subsequent glycoprotein (GP) IIb-IIIa-dependent thrombus formation at arterial flow rates is initiated through binding of von Willebrand factor (VWF) to the platelet GP Ib-IX-V complex, the
MRI Compatible DC Modulator for an Envelope Tracking Transmitter (2019)

Typical MRI power amplifiers are characterized by the requirement for high linearity and a high peak-to-average power ratio. When implemented as a linear amplifier, such as the commonly used Class-AB architecture this leads to a low efficiency and high heat dissipation, which impacts performance and reliability. Here we present a MRI compatible DC modulator for envelope tracking applications based on a 4-phase interleaved buck converter using air core magnetics and utilizing a FPGA based digital controller. The modulator is capable of delivering 500 W into a 2.5 Ω load at an efficiency of 95.6%, has a 3 dB modulation bandwidth of 50 kHz, and has been tested with a Class-AB linear amplifier operating at 64 MHz to produce a modulated RF envelope with a peak power of 320 W. Due to the higher efficiency of envelope tracking amplifiers and the ability to mount the amplifier directly on the MRI machine itself this system has the potential to decrease both the cost and space requirements of MRI machines.
A transform coding chip set for image compression (2002)

Two application-specific integrated circuits (ASICs) were designed to perform hierarchical transformation (S-transform processor) and Lempel-Ziv entropy coding (data compressor/decompressor). The chips can be used independently or together as a transform coding chip set for image compression. The algorithms and chip architectures of the transform codec (S-transform processor) and the entropy codec (data compressor/decompressor) are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ChemInform Abstract: Synthesis and Properties of Azoles and Their Derivatives. Part 18. A New, Convenient Method for the Dehydrogenation of 3,5‐Diaryl‐4‐nitro‐4,5‐dihydro‐1,2‐oxazoles. (1989)

ChemInformVolume 20, Issue 23 Heterocyclic Compounds ChemInform Abstract: Synthesis and Properties of Azoles and Their Derivatives. Part 18. A New, Convenient Method for the Dehydrogenation of 3,5-Diaryl-4-nitro-4,5-dihydro-1,2-oxazoles. A. BARANSKI, A. BARANSKI Inst. Org. Chem. Technol., Polytech. Univ., 31155 KrakowSearch for more papers by this authorE. CHOLEWKA, E. CHOLEWKA Inst. Org. Chem. Technol., Polytech. Univ., 31155 KrakowSearch for more papers by this author A. BARANSKI, A. BARANSKI Inst. Org. Chem. Technol., Polytech. Univ., 31155 KrakowSearch for more papers by this authorE. CHOLEWKA, E. CHOLEWKA Inst. Org. Chem. Technol., Polytech. Univ., 31155 KrakowSearch for more papers by this author First published: June 6, 1989 https://doi.org/10.1002/chin.198923171Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume20, Issue23June 6, 1989 RelatedInformation
In vitro Activity of Piperacillin/Tazobactam against 615 <i>Pseudomonas aeruginosa</i> Strains Isolated in Intensive Care Units (1998)

From May 1996 to September 1997, 615 Pseudomonas aeruginosa strains isolated from patients in intensive care units collected from different Italian laboratories were studied. The susceptibility of piperacillin/tazobactam, in comparison with other antipseudomonal antibiotics, to their NCCLS breakpoints was evaluated: amikacin 79. 6%, carbenicillin 67.0%, ceftazidime 73.4%, ciprofloxacin 55.8%, imipenem 64.1%, piperacillin 88.1%, piperacillin/tazobactam 92.4% and ticarcillin/clavulanic acid 69.0%. Seventy-three strains were selected because of their resistance to piperacillin and the mechanisms underlying such a resistance were investigated. Isoelectric focusing and hydrolysis assays revealed the presence of 15 plasmid-mediated beta-lactamases. Chromosomal beta-lactamase derepression was demonstrated in 34 isolates. The remaining 24 piperacillin-resistant strains did not produce beta-lactamases and an 'intrinsic mechanism' of resistance was inferred. The piperacillin/tazobactam combination restored resistance in 25 piperacillin strains. Nine of these were derepressed for chromosomal beta-lactamase, 8 showed impermeability and 8 showed plasmid enzymes.
Erratum: “Dissociation of grain boundary dislocations in SrBi2Ta2O9 ferroelectric thin films” [Appl. Phys. Lett. <b>79</b>, 1345 (2001)] (2001)

Due to a production error, an overbar was missing from the top of Fig. AIP apologizes for this error. Figure 2 appears correctly below: FIG. 2. Schematic diagram for a small-angle pure tilt grain boundary composing of edge-dislocation array with Burger's vector b a 2 110 parallel to the x axis, in which D is the total dislocation spacing and R is the separation distance between the partials.
Regioselective solid-phase synthesis of N-mono-hydroxylated and N-mono-methylated acylpolyamine spider toxins using an 2-(ortho-nitrophenyl)ethanal-modified resin (2015)

A recently introduced new SPS resin, possessing a 2-(ortho-nitrophenyl)ethanal linker, was used for the regioselective on-resin synthesis of N-mono-hydroxylated and N-mono-methylated polyamine spider toxins of Agelenopsis aperta and Larinioides folium. The polyamine backbones of the target compounds were efficiently constructed from the center by reductive amination of the aldehyde linker, followed by stepwise alkylation and acylation on solid support. Depending on the cleavage conditions, employing either oxidation/Cope elimination or methylation/Hofmann elimination, regioselectively the respective N-hydroxyl or N-methyl products were obtained. Employing this methodology, a number of acylpolyamine spider toxins were synthesized and identified as venom components by UHPLC and ESI-MS/MS.
Development and demonstration of flueric sounding rocket motor ignition (1974)

Preoperative bilateral breast MR imaging for staging of breast cancer was associated with a reduced risk of contralateral breast recurrence; however, no observed reduction in risk of local-regional or distant recurrence was shown.
Flight-Determined, Subsonic, Lateral-Directional Stability and Control Derivatives of the Thrust-Vectoring F-18 High Angle of Attack Research Vehicle (HARV), and Comparisons to the Basic F-18 and Predicted Derivatives (1999)

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 NOMENCLATURE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 VEHICLE DESCRIPTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Hardware Configuration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Thrust-Vectoring Control System. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Software Configuration. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Co...
Rhenium diboride’s monocrystal elastic constants, 308 to 5 K (2010)

The five independent moduli required to construct the complete monocrystal elastic modulus tensor of the hexagonal-symmetry superhard compound ReB(2) were measured from 308 to 5 K using resonant ultrasound spectroscopy on a special-texture polycrystal. This is possible because, confirmed by X-ray diffraction, the specimen measured was composed of grains with hexagonal axes parallel so that its polycrystal elastic response is identical to a monocrystal and because hexagonal-symmetry solids are elastically isotropic in the plane perpendicular to the hexagonal axis. Along the hexagonal (c) axis, C(33) (0) = 1021 GPa, nearly equal to C(11) of diamond, and consistent with the superhard properties. However, in the (softer) isotropic plane, C(11) (0) = 671 GPa, much lower than diamond. The changes of C(ij) with temperature are very small and smooth. The Debye temperature was computed to be 738 K, and using a high-temperature approximation, the Grüneisen parameter is γ = 1.7.
Correlated level shifting technique with cross-coupled gain-enhancement capacitors (2009)

A new technique is proposed to compensate for the loop gain degradation in correlated level shifting. The technique allows the use of a simple single-stage opamp with low gain to realise high effective loop gain. The effect of gain variations on the performance of the proposed correlated level shifting technique is discussed.
Novel Uses of Biochar (2013)

Cascading Uses of Biochar - Hans-Peter Schmidt, Ithaka Institute In addition to the use of biochar as a soil amendment, there are an increasing number of ways to incorporate biochar into different eco- and industrial systems. Thus feeding biochar to livestock has numerous benefits not only for the animals, but it also helps reduce greenhouse gas emissions and improves nutrient retention in animal manure. The use of biochar in building materials is just beginning to be studied but shows promise in the ability to insulate, decontaminate air, provide odor and humidity control. Biochar as pillow filling to induce perfectly reposing sleep is just another way to benefit from biochar's multiple qualities. There are more than 55 uses of biochar that can all be combined in cascades. All of these uses have in common that the biochar gets slowly charged with nutrients, gets oxidized and can finally be recycled as a soil conditioner. This session will introduce participants to a broad range of novel and cascading uses of biochar.
Multi-Beam Reflector Antenna System Combining Beam Hopping and Size Reduction of Effectively Used Spots (2012)

This paper describes a concept combining beam hopping and size reduction of effectively used spots that can be implemented on multiple-beam antennas to improve their performance, namely the carrier-to-interference ratio, the minimum directivity, and the roll-off. The expected impact on antenna RF performance is demonstrated based on simplified models. A more-realistic focal-array-fed reflector antenna is also presented, based on a cell-reuse scheme of 12 reduced to four (one-third of the coverage receiving all the available bandwidth according to a cell-reuse scheme of four at a given instant), with performance in line with the simplified model. This specific design enabled improving the antenna's performance without drastically increasing its complexity: the minimum directivity and C/I were respectively 1.67 dB and 3.65 dB higher when compared to a standard antenna implementation with a cell-reuse scheme of four.
Filter correlation photometer (1983)

A nondispersive photometer has been developed featuring a novel harmonic signal analysis for application oriented choice of functional components. These consist of rotating gas filters and interference filters as well as solid-state and optoacoustic detectors. Applications include direct measurement of concentration ratios. Simple models explaining the features of functional components as well as calibration procedures are given. Experimental data are presented, in comparison.