gebhart/patrepeval huggingface dataset:
Characterization of Marine Aerosol for Assessment of Human Exposure to Brevetoxins (2005)

Red tides in the Gulf of Mexico are commonly formed by the fish-killing dinoflagellate Karenia brevis, which produces nine potent polyether brevetoxins (PbTxs). Brevetoxins can be transferred from water to air in wind-powered white-capped waves. Inhalation exposure to marine aerosol containing brevetoxins causes respiratory symptoms. We describe detailed characterization of aerosols during an epidemiologic study of occupational exposure to Florida red tide aerosol in terms of its concentration, toxin profile, and particle size distribution. This information is essential in understanding its source, assessing exposure to people, and estimating dose of inhaled aerosols. Environmental sampling confirmed the presence of brevetoxins in water and air during a red tide exposure period (September 2001) and lack of significant toxin levels in the water and air during an unexposed period (May 2002). Water samples collected during a red tide bloom in 2001 showed moderate-to-high concentrations of K. brevis cells and PbTxs. The daily mean PbTx concentration in water samples ranged from 8 to 28 microg/L from 7 to 11 September 2001; the daily mean PbTx concentration in air samples ranged from 1.3 to 27 ng/m(3). The daily aerosol concentration on the beach can be related to PbTx concentration in water, wind speed, and wind direction. Personal samples confirmed human exposure to red tide aerosols. The particle size distribution showed a mean aerodynamic diameter in the size range of 6-12 microm, with deposits mainly in the upper airways. The deposition pattern correlated with the observed increase of upper airway symptoms in healthy lifeguards during the exposure periods.
Er-Yb double-clad fiber amplifier (2004)

We present model calculations of gain at 1550 nm for Er-Yb double-clad amplifiers as a function of pump power, signal input power, fiber length, and temperature. The calculated gain is ~20 dB for a 6-W pump for a 20-mW input signal at 25 C. More than 10 W of amplified power can be obtained using an 8-m-long fiber with ~25 W of pump power. The gain decreases with increasing input signal. We show that a high-power Er-Yb codoped double-clad fiber amplifier also exhibits high gain for Yb transition near 1060 nm. This is not unexpected, since the input pump causes population inversion in Yb also.
Model of malignant pleural effusion of human lung adenocarcinoma in SCID mice. (1997)

Malignant pleural effusion (PE) is a frequent problem in lung cancer. In this study, we established a model of malignant PE of human adenocarcinoma cells, PC-14, in SCID mice. Intravenously injected PC-14 cells formed colonies in the lungs as early as week 4 after tumor inoculation, and produced bloody PE in all recipient SCID mice by week 8. Pretreatment of SCID mice with anti-mouse IL-2 receptor beta chain antibody (TM-beta 1) to deplete natural killer (NK) cells markedly promoted the production of bloody PE and metastases to multiple organs, such as the lungs, liver, kidneys, and lymph nodes 4 weeks after tumor inoculation. Histological studies indicated that PC-14 cells formed colonies in the lungs, and then invaded the pleura and spread to the pleural cavity. To establish cell lines with a high potential to produce PE, we harvested PE, expanded the tumor cells in vitro, and injected them into SCID mice again. By four in vivo selection cycles in this way we obtained PC-14-PM4 cells, which produce lung metastases and PE earlier than PC-14 cells. The survival of SCID mice inoculated with PC-14-PM4 cells was significantly shorter than that of mice inoculated with PC-14 cells. The expressions of adhesion molecules, such as CD44, CD49d, ICAM-1, and MHC class I, on PC-14-PM4 cells tended to increase compared with PC-14 cells. These changes of adhesion molecules seem to be one of possible mechanisms involved in higher metastatic potential of PC-14-PM4 cells. PE models with PC-14 and PC-14-PM4 cells should be useful for biological and preclinical studies on malignant PE produced by human lung cancer.
Mixed-size concurrency: ARM, POWER, C/C++11, and SC (2016)

Previous work on the semantics of relaxed shared-memory concurrency has only considered the case in which each load reads the data of exactly one store. In practice, however, multiprocessors support mixed-size accesses, and these are used by systems software and (to some degree) exposed at the C/C++ language level. A semantic foundation for software, therefore, has to address them.
Transferrin Receptor in Human Placental Brush Border Membranes (1979)

Evidence is presented demonstrating the existence of a receptor specific for transferrin on the brush border membrane of the human syncytial trophoblast. Equilib- rium-binding studies were conducted using a placental vesicle preparation to demonstrate the presence of a high affinity, saturable binding site for ‘251-ferrotrans- ferrin on placental membranes. The K, for this binding site was determined by Scatchard analysis to be 3.6 + 1.5 S.D.
THE DRAMA BEHIND ELGAR'S MUSIC (1942)

THE DRAMA BEHIND ELGAR'S MUSIC Get access A. E. F. DICKINSON A. E. F. DICKINSON Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume XXIII, Issue 2, April 1942, Pages 116–125, https://doi.org/10.1093/ml/XXIII.2.116 Published: 01 April 1942
Clade D<i>Symbiodinium</i>in Scleractinian Corals: A “Nugget” of Hope, a Selfish Opportunist, an Ominous Sign, or All of the Above? (2010)

Clade D Symbiodinium are thermally tolerant coral endosymbionts that confer resistance to elevated sea surface temperature and bleaching to the host. The union between corals and clade D is thus important to management and coral conservation. Here, we review the diversity and biogeography of clade D Symbiodinium , factors linked to increasing abundances of clade D, and the benefits and drawbacks of associating with clade D for corals. We identify clade D Symbiodinium as uncommon pandemically distributed generalists found in higher abundances on reefs exposed to challenging sea surface temperatures and local stressors or with a history of bleaching. This distribution suggests that clade D Symbiodinium are mostly opportunistic endosymbionts, whereby they outcompete and replace optimal symbionts in health-compromised corals. We conclude by identifying research gaps that limit our understanding of the adaptive role clade D Symbiodinium play in corals and discuss the utility of monitoring clade D Symbiodinium as indicators of habitat degradation in coral reef ecosystems.
A Digital Ultrasonic System for Small Animal Imaging (2004)

In this paper, a 50 MHz digital ultrasonic imaging system designed for small animals and its applications to mouse embryos and tumors are presented. Utilizing the programmability of a fully digital system, several advanced imaging techniques are developed and implemented. A synthetic aperture focusing technique is implemented to increase the penetration and extend the depth of focus of a mechanical scan system using a high frequency single crystal transducer. An adaptive weighting technique is introduced to further reduce the sidelobes and enhance image contrast. Experimental results demonstrate efficacy of the proposed two-step adaptive focusing technique. For flow imaging, several flow estimation algorithms are evaluated. Simulations and flow phantom experiments show that the butterfly search technique offers superior flow imaging performance particularly when the SNR is low and the pulse bandwidth is high. The system is tested by imaging mouse embryos and microcirculation of a mouse tumor in vivo. It is demonstrated that the system is capable of simultaneously acquiring B-mode, color Doppler mode and power Doppler mode small animal images. The system set-up, adaptive focusing technique, flow estimation algorithms and imaging results are shown.
Composition of Plaque and Saliva Following a Sucrose Challenge and Use of an a-tricalcium-phosphate-containing Chewing Gum (1998)

Calcium phosphate concentrations in plaque, plaque fluid, and saliva play an important role in caries prevention. In this study, we used a microanalytical technique to examine the anticaries potential of a 2.5% (mass fraction) alpha-tricalcium-phosphate-fortified experimental gum by measuring the pH, free and total calcium, and total phosphate in plaque fluid, whole plaque, and saliva, and centrifuged saliva from 14 subjects who (1) accumulated plaque for 48 hours, (2) fasted overnight, (3) rinsed for 1 min with sucrose, and (4) chewed a control or experimental gum for 15 min. From these data, the hydroxyapatite (HAp) ion activity products (IAP[HAp]) of saliva and plaque fluid were calculated as a measure of tooth mineral saturation. Results, compared with those of the control gum, show significant increases in pH and in free calcium and phosphate concentrations in plaque fluid and saliva when the experimental gum was chewed following sucrose ingestion. These increases result in a rise in fluid saturation with respect to tooth mineral that, for plaque fluid, nearly cancels the decrease seen with the control gum after the sucrose rinse. This suggests that the experimental gum may be more effective than a conventional gum in ameliorating the cariogenic effects of sucrose. Similar statistically significant increases were also seen in the total calcium content of the plaque fluid, centrifuged saliva, whole saliva, and whole plaque, and in the total phosphate of whole plaque and whole saliva. These results suggest that the deposition of a mineral reservoir in plaque and saliva by the experimental gum may help resist future cariogenic challenges.
The PASADENA Effect at a Solid Surface:  High-Sensitivity Nuclear Magnetic Resonance of Hydrogen Chemisorption (2001)

The use of parahydrogen as a high-sensitivity spin label for nuclear magnetic resonance (NMR) was first proposed and then demonstrated to provide orders-of-magnitude signal enhancement in species which are formed from the molecular addition of hydrogen. The phenomenon known as the PASADENA effect (parahydrogen and synthesis allow dramatically enhanced nuclear alignment) derives from the fact that deviation of the parahydrogen mole fraction in a sample of H_2 from its statistical high-temperature limit of 1/4 is associated with an inherent form of spin order. Upon molecular addition of the two protons from a single H_2 molecule into coupled, magnetically inequivalent environments, this order is manifested as large nonequilibrium spin population differences across allowed NMR transitions.
Breast imaging reporting and data system standardized mammography lexicon: observer variability in lesion description. (1996)

BI-RADS is moderately successful in providing a standardized language for physicians to describe lesion morphology. Efforts to reevaluate specific terms and the diagnostic significance assigned to calcification descriptors may prove useful in maintaining the promise of improved quality with the BI-RADS standardized mammography lexicon.
Frequent Expression of Midkine Gene in Esophageal Cancer Suggests a Potential Usage of Its Promoter for Suicide Gene Therapy (1999)

We have examined the expression of midkine (MK), a neurotrophic factor with heparin-binding activity, in human esophageal cancer cells. Seven esophageal cell lines tested expressed the transcript and 8 out of 14 human esophageal tumor specimens were positively stained with anti-MK antibody, while surrounding normal esophageal tissues in these specimens were not stained. The 5'-flanking, 2.3 kb genomic region of the MK gene was shown to drive the transcription of a reporter gene in the esophageal cell lines in a cis acting manner. Forced expression in esophageal cancer cells of herpes simplex virus-thymidine kinase gene mediated by the flanking region of the MK gene conferred sensitivity to a prodrug, ganciclovir. The 5'-upstream region of the MK gene thus possesses putative promoter activity which can be used for suicide gene-based gene therapy for esophageal cancer.
Peripheral spatial vision: limits imposed by optics, photoreceptors, and receptor pooling (1991)

We examined the contribution of optical and photoreceptor properties as well as receptor pooling to eccentricity-dependent variations in spatial vision by comparing the performance of ideal observers with that of human observers. We measured contrast sensitivity functions in human observers and calculated such functions in ideal observers for retinal eccentricities of 0-40 deg. Comparisons of human and ideal performance in a variety of tasks reveal that many aspects of the variation in spatial vision with eccentricity can be understood from an analysis of the discrimination information available at the retinal ganglion cells.
Color generation<i>via</i>subwavelength plasmonic nanostructures (2015)

Recent developments in color filtering and display technologies have focused predominantly on high resolution, color vibrancy, high efficiency, and slim dimensions. To achieve these goals, metallic nanostructures have attracted extensive research interest due to their abilities to manipulate the properties of light through surface plasmon resonances. In this paper, we review recent representative developments in plasmonic color engineering at the nanoscale using subwavelength nanostructures, demonstrating their great potential in high-resolution and high-fidelity color rendering, spectral filtering applications, holography, three-dimensional stereoscopic imaging, etc.
Efficient 3D Object Detection by Fitting Superquadrics to Range Image Data for Robot's Object Manipulation (2007)

Fast detection of objects in a home or office environment is relevant for robotic service and assistance applications. In this work we present the automatic localization of a wide variety of differently shaped objects scanned with a laser range sensor from one view in a cluttered setting. The daily-life objects are modeled using approximated superquadrics, which can be obtained from showing the object or another modeling process. Detection is based on a hierarchical RANSAC search to obtain fast detection results and the voting of sorted quality-of-fit criteria. The probabilistic search starts from low resolution and refines hypotheses at increasingly higher resolution levels. Criteria for object shape and the relationship of object parts together with a ranking procedure and a ranked voting process result in a combined ranking of hypothesis using a minimum number of parameters. Experiments from cluttered table top scenes demonstrate the effectiveness and robustness of the approach, feasible for real world object localization and robot grasp planning.
Spontaneous Contractions Evoke Afferent Nerve Firing in Mouse Bladders With Detrusor Overactivity (2009)

Large amplitude, spontaneous bladder contractions evoke afferent nerve activity, which may contribute to incontinence.
Evolution of Molecular Weight and Long Chain Branch Distributions in Olefin–Diene Copolymerization (2003)

Abstract A model for olefin–diene copolymerization and long chain branch formation was developed. The model shows that the number‐average molecular weight and branching density increases linearly with time in a semi‐batch polymerization, while the polydispersity depends on the diene content in the polymer and on the polymerization time. For low diene fractions or low polymerization times, the polydispersity increases linearly with time. For higher diene contents, the polydispersity increases exponentially with polymerization time after a critical polymer concentration is reached. The calculated distributions of branched species indicate that diene content influences the amount of highly branched chains produced in the polymerization, markedly broadening the distribution of molecular weight and leading to gel formation. Weight distribution of branched species after 30 min of polymerization. magnified image Weight distribution of branched species after 30 min of polymerization.
Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk (2019)

Mutations have a profound effect on human health, particularly through an increased risk of carcinogenesis and genetic disease. The strong correlation between mutagenesis and carcinogenesis has been a driving force behind genotoxicity research for more than 50 years. The stochastic and infrequent nature of mutagenesis makes it challenging to observe and to study. Indeed, decades have been spent developing increasingly sophisticated assays and methods to study these low-frequency genetic errors, in hopes of better predicting which chemicals may be carcinogens, understanding their mode of action, and informing guidelines to prevent undue human exposure. While effective, widely used genetic selection-based technologies have a number of limitations that have hampered major advancements in the field of genotoxicity. Emerging new tools, in the form of enhanced next-generation sequencing platforms and methods, are changing this paradigm. In this review, we discuss rapidly evolving sequencing tools and technologies, such as error-corrected sequencing and single cell analysis, which we anticipate will fundamentally reshape the field. In addition, we consider a variety emerging applications for these new technologies, including the detection of DNA adducts, inference of mutational processes based on genomic site and local sequence contexts, and evaluation of genome engineering fidelity, as well as other cutting-edge challenges for the next 50 years of environmental and molecular mutagenesis research. Environ. Mol. Mutagen. 61:135-151, 2020. © 2019 The Authors. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society.
ChemInform Abstract: Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cascode circuits for switched current copiers (1997)

Various cascode circuits are investigated with regard to their suitability for switched current copier applications. Generalized circuit representations are introduced and different cascode circuits are compared and discussed. A method called "reference voltage and current tracking" for dynamic output range improvement is proposed. An improved regulated cascode circuit with extended dynamic output range is presented. The use of cascode circuits in switched current copiers and the dynamic output ranges of these circuits are discussed and the corresponding saturation operating areas are compared.
A Simple Way to Improve Anatomical Mapping of Functional Brain Imaging (2010)

This study describes a simple, rapid, and easily implementable method to significantly improve neuroanatomical accuracy of fMRI results localization, which may be relevant for future neuroimaging studies.
Growth of High Crystalline Quality HVPE-GaN Crystals with Controlled Electrical Properties (2015)

Thick free-standing hydride vapor phase epitaxy (HVPE) GaN wafers were grown with close to perfect crystalline quality and with more than two orders of magnitude reduced free carrier concentration relative to ammonothermal GaN without resorting to deep level compensation. These new homoepitaxially grown crystals exceed the quality of any commercially available GaN substrates. High crystalline quality is confirmed by XRD rocking curve measurements having full width at half-maximum of only 16 arc s. Detailed Raman scattering spectroscopy and imaging show that the wafers are biaxially stress-free and have a uniform and low background doping. The stress-free, flat nature of these substrates is essential for high-yield device fabrication. High-resolution photoluminescence studies in combination with SIMS analysis identify Si and O as residual shallow donors with concentration levels orders of magnitude lower than those present in ammonothermal GaN substrates.
Identification of a Meander Region Proline Residue Critical for Heme Binding to Cytochrome P450:  Implications for the Catalytic Function of Human CYP4B1 (1998)

Alignment of xenobiotic-metabolizing P450 protein sequences highlights an invariant proline residue in the meander region two amino acids N-terminal to the distal arginine of the putative ERR triad thought to be important for heme binding. This occurs as a serine in the sequences derived from human CYP4B1 gDNA and both human lung and placental CYP4B1 cDNAs. Reversion of this serine to the conserved proline residue (Ser427 --> Pro) by site-directed mutagenesis conferred the ability to incorporate heme on the human placental enzyme. Mutation of the corresponding proline in rabbit CYP4B1 (Pro422 --> Ser) abolished heme incorporation. Membrane preparations of human CYP4B1(Pro) and rabbit CYP4B1(Pro), but not the corresponding CYP4B1(Ser) variants, supported lauric acid hydroxylation preferentially at the omega-position. Purified, reconstituted human CYP4B1(Pro) and rabbit CYP4B1(Pro) formed 12-hydroxylauric acid at rates of 17-21 min-1, and both enzymes were also C-8 to C-10 fatty acid omega-hydroxylases preferentially, with total rates of hydroxylation decreasing in the order C-12 > C-10 > C-9 > C-8. Finally, neither human nor rabbit CYP4B1(Pro) formed detectable levels of any hydroxylated testosterone metabolites. Therefore, the presence of a consensus Pro-X-Arg motif is critical for incorporation of the heme prosthetic group in human and rabbit CYP4B1 proteins expressed in insect cells. Native human CYP4B1, expressed in vivo, is likely to be functionally impaired if Pro427 is required for holoenzyme expression in mammalian cells.
Highly Stable Graphene‐Based Multilayer Films Immobilized via Covalent Bonds and Their Applications in Organic Field‐Effect Transistors (2012)

Abstract Highly stable graphene oxide (GO)‐based multilayered ultrathin films can be covalently immobilized on solid supports through a covalent‐based method. It is demonstrated that when (3‐aminopropyl) trimethoxysilane (APTMS), which works as a covalent cross‐linking agent, and GO nanosheets are assembled in an layer‐by‐layer (LBL) manner, GO nanosheets can be covalently grafted on the solid substrate successfully to produce uniform multilayered (APTMS/GO) N films over large‐area surfaces. Compared with conventional noncovalent LBL films constructed by electrostatic interactions, those assembled using this covalent‐based method display much higher stability and reproducibility. Upon thermal annealing‐induced reduction of the covalent (APTMS/GO) N films, the obtained reduced GO (RGO) films, (APTMS/RGO) N , preserve their basic structural characteristics. It is also shown that the as‐prepared covalent (APTMS/RGO) N multilayer films can be used as highly stable source/drain electrodes in organic field‐effect transistors (OFETs). When the number of bilayers of the (APTMS/RGO) N film exceeds 2 (ca . 2.7 nm), the OFETs based on (APTMS/RGO) N electrodes display much better electrical performance than devices based on 40 nm Au electrodes. The covalent protocol proposed may open up new opportunities for the construction of graphene‐based ultrathin films with excellent stability and reproducibility, which are desired for practical applications that require withstanding of multistep post‐production processes.