gebhart/patrepeval huggingface dataset:
Gastrocolic fistula. A review of 15 cases and an update of the literature. (1993)

Gastrocolic fistulas are not common. We review the 10-year experience in our center of 15 cases that emphasize the changing pattern of this disease. The female-to-male ratio was 2:1, with a mean age of 55. Even though we are affiliated with the regional cancer center, the commonest cause of a fistula was benign gastric ulceration. Sixty percent of those with peptic ulcer and a fistula had not had previous gastric surgery. Barium enema was the most accurate investigation, showing the fistula in 10 of 10. Barium meal showed it in seven of eight, and the fistula was seen in seven of 10 patients who had endoscopy. Eleven patients were operated on, and only one was treated "medically." Three deaths occurred, two from advanced carcinoma and one from myocardial infarction.
AN OVERVIEW OF DATA MINING IN ROAD TRAFFIC AND ACCIDENT ANALYSIS (2009)

able to introduce safety plans in order to prevent or reduce occurrences of accidents. The road traffic and Data mining is a promising area for dealing accident statistics must be presented in such a way to with the increased, stored data that has been generated make it easier to be both recognized and interpreted by in our times.It is the extraction of implicit, previously a human operator. Previous works on accident analysis unknown and useful data. In this paper we have included statistical methods and formal techniques. analyzed some of the data mining techniques, tools, Statistics tables and ordinary charting techniques are applications and search engines for accident not sufficient for present day requirements and this
Learning part-based templates from large collections of 3D shapes (2013)

As large repositories of 3D shape collections continue to grow, understanding the data, especially encoding the inter-model similarity and their variations, is of central importance. For example, many data-driven approaches now rely on access to semantic segmentation information, accurate inter-model point-to-point correspondence, and deformation models that characterize the model collections. Existing approaches, however, are either supervised requiring manual labeling; or employ super-linear matching algorithms and thus are unsuited for analyzing large collections spanning many thousands of models. We propose an automatic algorithm that starts with an initial template model and then jointly optimizes for part segmentation, point-to-point surface correspondence, and a compact deformation model to best explain the input model collection. As output, the algorithm produces a set of probabilistic part-based templates that groups the original models into clusters of models capturing their styles and variations. We evaluate our algorithm on several standard datasets and demonstrate its scalability by analyzing much larger collections of up to thousands of shapes.
Effect of Luminescent Coupling on the Optimal Design of Multijunction Solar Cells (2014)

We analyze the implications of luminescent coupling on multijunction cell design and performance, using a recently developed formalism that uses the measured luminescent coupling parameters as inputs to an analytical model of the full current-voltage (J-V) characteristic of the cell. This calculation of the full J-V curve allows the determination of the cell open-circuit voltage, short-circuit current, fill factor, and efficiency in the presence of luminescent coupling. We show that luminescent coupling affects critical aspects of the cell design that include the optimal junction thicknesses and bandgaps, and affects the dependence of the cell performance on the spectral content of the light illuminating it.
Second-Site Mutation Outside of the U <sub>S</sub> 10-12 Domain of Δγ <sub>1</sub> 34.5 Herpes Simplex Virus 1 Recombinant Blocks the Shutoff of Protein Synthesis Induced by Activated Protein Kinase R and Partially Restores Neurovirulence (2002)

Earlier studies have shown that herpes simplex virus type 1 (HSV-1) activated protein kinase R (PKR) but that the product of the product of the gamma(1)34.5 gene binds and redirects the host phosphatase 1 to dephosphorylate the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2alpha). In consequence, the gamma(1)34.5 gene product averts the threatened shutoff of protein synthesis caused by activated PKR. Serial passages of Deltagamma(1)34.5 mutants in human cells led to isolation of two classes of second-site, compensatory mutants. The first, reported earlier, resulted from the juxtaposition of the alpha promoter of the U(S)12 gene to the coding sequence of the U(S)11 gene. The mutant blocks the phosphorylation of eIF-2alpha but does not restore the virulence phenotype of the wild-type virus. We report another class of second-site, compensatory mutants that do not map to the U(S)10-12 domain of the HSV-1 genome. All mutants in this series exhibit sustained late protein synthesis, higher yields in human cells, and reduced phosphorylation of PKR that appears to be phosphatase dependent. Specific dephosphorylation of eIF-2alpha was not demonstrable. At least one mutant in this series exhibited a partial restoration of the virulence phenotype characteristic of the wild-type virus phenotype. The results suggest that the second-site mutations reflect activation of fossilized functions designed to block the interferon response pathways in cells infected with the progenitor of present HSV.
Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib (2020)

Through the use of SPPs, we were able to offer combination therapy targeting <i>MET</i>-amplified resistance identified on the first-in-human study of selpercatinib. These data suggest that MET dependence is a recurring and potentially targetable mechanism of resistance to selective RET inhibition in advanced NSCLC.
Synthesis of bridgehead bicyclo[2.2.2]octanols (1981)

The paper describes syntheses of bicyclo[2.2.2]octan-1-ol, its 4-methyl and 4-phenyl derivatives, and bicyclo[2.2.2]octane-1,4-diol.
CORDS: a knowledge-based remote diagnosis workstation (2003)

The authors describe a knowledge-based system called the Central Operations and Remote Diagnostic System (CORDS) which aids service personnel in the diagnosis of computers. A central operator receives trouble calls via voice line and then dials out from the workstation to the console of the failing unit. Novel features of the system include object-oriented graphical display of computer and site configurations using a direct manipulation interface, an intelligent maintenance assistant component which examines the logs of diagnostic output and suggests appropriate actions to the central maintenance operator, a fast compiled rule system, an intelligent database of trouble tickets, which are used to guide the diagnosis toward probable faults based on the site history, and concern for security in the diagnosis.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
THE DESULFURIZATION OF MERCAPTANS WITH TRIALKYL PHOSPHITES (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE DESULFURIZATION OF MERCAPTANS WITH TRIALKYL PHOSPHITESFriedrich W. Hoffmann, Richard J. Ess, Thomas C. Simmons, and Robert S. HanzelCite this: J. Am. Chem. Soc. 1956, 78, 24, 6414Publication Date (Print):December 1, 1956Publication History Published online1 May 2002Published inissue 1 December 1956https://pubs.acs.org/doi/10.1021/ja01605a034https://doi.org/10.1021/ja01605a034research-articleACS PublicationsRequest reuse permissionsArticle Views708Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Provisioning for probabilistic failures in multi-domain DWDM networks (2010)

This paper addresses multi-domain lightpath provisioning within the context of correlated multi-failure events. The work jointly incorporates both risk minimization and traffic engineering objectives, and develops a novel graph theoretic scheme for distributed operation in realistic optical network settings. Detailed performance evaluation results are then presented to gauge the effectiveness of the proposed multi-domain provisioning solution.
Variation Estimation and Compensation Technique in Scaled LTPS TFT Circuits for Low-Power Low-Cost Applications (2008)

Low-temperature polycrystalline-silicon thin-film transistor (LTPS TFT) has emerged as one of the promising candidates for low-power low-cost applications on flexible substrates. In this paper, we propose a statistical simulation methodology to estimate parametric variations in scaled LTPS TFT due to the inherent properties [such as the number, location, and orientation of grain boundaries (GBs)] of the polycrystalline material. Our simulation technique employs the response surface method (RSM) to consider multiple process parameters which affect the performance distribution of LTPS TFT devices/circuits. Simulation results show that inherent GB variations result in multimodal delay distributions in basic logic building blocks (inv, nand, and nor) in scaled LTPS TFT technology, contrary to unimodal distributions in conventional bulk CMOS technology. We also observed that with increasing logic depth, the multimodal distribution converges to a unimodal distribution. Hence, to ensure robust and stable functionality of TFT technology under inherent process variations, we propose a multifinger (MF) design technique to improve the reliability of TFT circuits and to reduce the impact of GB-induced variations on TFT performance. Simulation results obtained from a 20-stage inverter chain show that by applying the proposed MF-based design, one can achieve 28% and 61% reductions in delay variations using two- and four-finger structures, respectively.
Telmisartan has the strongest binding affinity to angiotensin II type 1 receptor: comparison with other angiotensin II type 1 receptor blockers. (2005)

There is a growing body of evidence that the renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases. Indeed, large clinical trials have demonstrated a substantial benefit of the blockade of this system for cardiovascular-organ protection. Although several types of angiotensin II type 1 (AT1) receptor blockers (ARBs) are commercially available for the treatment of patients with hypertension, comparisons of the binding affinity to AT1 receptor among them remain to be elucidated. In this study, we examined the dissociation rate of several ARBs from AT1 receptor in vitro. Angiotensin II time-dependently dissociated telmisartan, olmesartan, candesartan, valsartan, losartan and an active metabolite of losartan, EXP3174, from membrane components containing human AT1 receptor The dissociation rate constant of each ARB was 0.003248, 0.004171, 0.005203, 0.009946, 0.01027 and 0.008561 min(-1), with corresponding half-lives of 213, 166, 133, 70, 67 and 81 min, respectively. These results demonstrate that telmisartan has the strongest binding affinity to AT1 receptor among various ARBs examined herein. The rank order of affinity was telmisartan > olmesartan > candesartan > EXP3174 > or = valsartan > or = losartan. The present findings suggest that telmisartan (Micardis) may have long-lasting blood pressure-lowering effects and superior cardioprotective properties in patients with hypertension due to its strongest AT1 receptor antagonistic ability.
Scintillation properties and temperature responses of Cs<inf>2</inf>LiLaBr<inf>6</inf>:Ce<sup>3+</sup> (2013)

This report presents the scintillation properties and temperature dependent neutron and gamma responses of Cs <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> LiLaBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> elpasolite crystals with 0.5, 2, and 3.5% Ce doping. Cs <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> LiLaBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> has excellent scintillation light output proportionality, high light output, and good energy resolution. It also shows good light output temperature stability. Pulse shape differences between neutron and gamma excited pulses are analyzed as a function of temperature. Neutron-gamma pulse shape discrimination is possible in a wide temperature range from -10°C up to at least 140 °C.
Success of a Safe and Simple Algorithm to Reduce Use of CT Pulmonary Angiography in the Emergency Department (2010)

The practice patterns of physicians changed in response to an educational intervention, resulting in a reduction in radiation exposure to emergency department patients with suspected PE without compromising patient safety.
Dietary Carbohydrate Content Determines Responsiveness to Growth Hormone in Energy-Restricted Humans* (1989)

To determine if diet composition influences responses to GH, we fed 11 obese women diets containing 12 Cal/kg ideal BW (IBW) for 2 5-week study intervals. Nonprotein calories were supplied to 6 subjects as 72% carbohydrate (high carbohydrate diet), and 5 subjects received 80% of their nonprotein calories as lipid (high lipid diet). Protein intake was constant (1.0 g/kg IBW) in both groups. During 1 study interval we gave injections of GH (0.1 mg/kg IBW) every other day for 3 weeks (weeks 2-4), and in the other interval injections of vehicle were given. Subjects ingesting the high carbohydrate diet excreted significantly less urinary nitrogen [660.2 +/- 124.1 mmol/day (mean +/- SD)] than those who received high lipid (794.2 +/- 198.5 mmol/day; P less than 0.001), and GH injections reduced nitrogen excretion in the high carbohydrate subjects (532.8 +/- 123.8 mmol/day), but not in the high lipid subjects (743.7 +/- 126.6 mmol/day). The subjects receiving the high carbohydrate diet had a significant increase in serum insulin-like growth factor-I (IGF-I; from 36.2 +/- 9.7 to 55.9 +/- 6.6 nmol/L) and urinary C-peptide excretion (from 43.9 +/- 25.6 to 60.8 +/- 29.4 nmol/day) in response to GH. The IGF-I response attenuated slowly over the 3-week treatment interval. On the other hand, the high lipid group had lesser increases in IGF-I (from 31.0 +/- 6.5 to 41.7 +/- 8.8 nmol/L) and C-peptide excretion (from 24.3 +/- 28.9 to 29.8 +/- 32.8 nmol/day), and IGF-I concentrations declined to control values after only 5 days of GH injection. We believe that this initial IGF-I response was due to an antecedent 35-Cal balanced diet. The mean increment in serum FFA 4 h after GH injection was significantly less in subjects fed the high lipid diet (0.53 +/- 0.40 meq/L) than in those fed the high carbohydrate diet (0.83 +/- 0.43 meq/L). GH injections produced more body fat loss than injections of vehicle whether expressed as percent body fat lost (GH, 3.7 +/- 1.0%; vehicle, 2.8 +/- 0.7%, P less than 0.05) or as the fraction of weight lost as fat (fat loss/weight loss; GH, 0.81 +/- 0.13; vehicle, 0.64 +/- 0.08; P less than 0.005). There was an inverse correlation between the percentage of body fat lost and mean urinary C-peptide excretion during GH injections (r = -0.70; P less than 0.05), suggesting that stimulation of insulin secretion by GH might antagonize the tendency of GH to promote fat loss.(ABSTRACT TRUNCATED AT 400 WORDS)
Metal Gratings with Dielectric Coating of Variable Thickness within a Period (1991)

Abstract The rigorous theory of diffraction is applied to metallic gratings with dielectric coating. The modulation depth of the profile between coating and air is assumed to be lower than the modulation depth of the profile between metal and coating. We call this levelling. For monochromator mounting together with a special coating thickness levelled single-coated gratings with blaze show a marked increase of the efficiencies for wavelengths greater than the blaze maximum wavelength. Optimal improvements run over two octaves of the wavelength.
Studies on Glass. VIII. The Coefficient of Thermal Expansion of Boron Trioxide. (1934)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on Glass. VIII. The Coefficient of Thermal Expansion of Boron Trioxide.Monroe E. SpaghtMonroe E. SpaghtMore by Monroe E. Spaght and George S. ParksGeorge S. ParksMore by George S. ParksCite this: J. Phys. Chem. 1934, 38, 1, 103–110Publication Date (Print):January 1, 1934Publication History Published online1 May 2002Published inissue 1 January 1934https://doi.org/10.1021/j150352a010RIGHTS & PERMISSIONSArticle Views104Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (453 KB) Get e-Alerts
The Trademark Disclaimer Provision of the Lanham Act: Is USPTO Flexibility Worth Litigant Ambiguity?, 17 J. Marshall Rev. Intell. Prop. L. 305 (2018) (2018)

Most trademark applicants and the attorneys who counsel them are familiar with the requirement that they disclaim terms within their trademarks because those terms are descriptive or generic. The United States Patent and Trademark Office’s authority to direct applicants to disclaim terms is codified in the Trademark Disclaimer Provision of the Lanham Act, which provides examiners with a great deal of discretion. The same provision has been interpreted as providing applicants with the options of: taking conflicting positions, e.g., that the term is neither descriptive nor generic in the context of their marks, when asserting common law rights; and pursuing rights without disclaiming the term when there has been a showing of secondary meaning. But for all of the ease of implementation and application, now, more than half of a century since codification of the Trademark Disclaimer Provision, one should consider whether it is worth the effort and ask: Does anyone gain by allowing examiners to require that applicants disclaim generic and descriptive portions of their marks?
Yolk vitronectin. Purification and differences from its blood homologue in molecular size, heparin binding, collagen binding, and bound carbohydrate. (1992)

This is the first report on a unique vitronectin molecule, yolk vitronectin, which is similar to its blood homologue in cell spreading activity but different in molecular size, bound carbohydrate, and heparin and collagen binding activity. Yolk vitronectin was purified 2,500-fold from chick egg yolk by a combination of hydroxylapatite, DEAE-cellulose, and anti-vitronectin-Sepharose column chromatographies. In SDS-polyacrylamide gel electrophoresis under reducing conditions, yolk vitronectin was separated into 54- and 45-kDa bands, which are 16 and 25 kDa smaller, respectively, than the 70-kDa major band of chick blood vitronectin. The 54-kDa band shares the same NH2-terminal sequence as chick blood vitronectin. In contrast, the NH2-terminal sequence of the 45-kDa band is somewhat homologous with the internal sequences of mammalian vitronectins beginning at the 50th amino acid from the NH2 terminus. The bound carbohydrate of the 54- and 45-kDa species of yolk vitronectin is similar to, but distinct from, that of blood vitronectin. Unlike blood vitronectin, yolk vitronectin cannot bind to either heparin or collagen.
Metals as Regulators of Heme Metabolism (1977)

Heme is essential for cell respiration, energy generation, and oxidative biotransformations. The latter function is exemplified by the oxidative metabolism of various endogenous and exogenous chemicals catalyzed by the heme protein cytochrome P-450. Recent studies have established that metal ions directly regulate cellular content of heme, and thus of heme proteins by controlling production of delta-aminolevulinate synthetase and heme oxygenase, the rate-limiting enzymes for heme synthesis and degradation, respectively. Metal ions also alter cellular content of glutathione. In excess amounts, metal ions greatly accelerate the turnover and degradation of heme and substantially impair the oxidative functions of cells--particularly those dependent on cytochrone P-450. As a result, the biological impact of chemicals which are detoxified or metabolically transformed by the P-450 system is greatly altered.
Electrocaloric effect in low-crystallinity ferroelectric polymers (2012)

The role of the sample crystallinity on the electrocaloric effect (ECE) of ferroelectric polymers was investigated in miscible blends of poly(vinylidene fluoride-trifluoroethylene) and poly(methyl methacrylate). Polarization switching measurements gave the electric field required to realize full dipole realignment. Conformational entropy and temperature changes were obtained from the thermal dependence of the dielectric permittivity in the paraelectric phase. The obtained ECE values were relatively high: they reached 18.6 J/kgK and 4.7 K for the pure copolymer and decreased ca. 74% for a 70% crystallinity decreasing. The sample crystallinity appears clearly as a key parameter controlling the ECE in non-oriented ferroelectric polymers.
New Developments in Diesel Oxidation Catalysts (2008)

<div class="htmlview paragraph">A number of oxidation catalysts have been prepared using different types of advanced support materials such as ceria-zirconia, silica-titania, spinels and perovskites. Active metals such as Pd and Au-Pd were loaded by conventional impregnation techniques and/or deposition-precipitation methods. A liquid hydrocarbon delivery system was designed and implemented for the catalyst test benches in order to simulate the diesel engine exhaust environment. The activity of fresh (no degreening) catalysts was evaluated with traditional CO and light hydrocarbons (C<sub>2</sub>H<sub>4</sub>, C<sub>3</sub>H<sub>6</sub>) as well as with heavy hydrocarbons such as C<sub>10</sub> H<sub>22</sub>.</div>
Superiority of Transcriptional Profiling Over Procalcitonin for Distinguishing Bacterial From Viral Lower Respiratory Tract Infections in Hospitalized Adults (2015)

Transcriptional profiling is a helpful tool for diagnosis of LRTI.