gebhart/patrepeval huggingface dataset:
Model clone detection in practice (2010)

Cloned code is considered harmful for two reasons: (1) multiple, possibly unnecessary, duplicates of code increase maintenance costs and, (2) inconsistent changes to cloned code can create faults and, hence, lead to incorrect program behavior. Likewise, duplicated parts of models are problematic in model-based development. Recently, we and other authors proposed multiple approaches to automatically identify duplicates in graphical models. While it has been demonstrated that these approaches work in principal, a number of challenges remain for application in industrial practice. Based on an industrial case study undertaken with the BMW Group, this paper details on these challenges and presents solutions to the most pressing ones, namely scalability and relevance of the results. Moreover, we present tool support that eases the evaluation of detection results and thereby helps to make clone detection a standard technique in model-based quality assurance.
Photoconductivity and Photoemission of Diamond Under Femtosecond Vuv Irradiation (2005)

In order to gain some insight on the electronic relaxation mechanisms occuring in diamond under high intensity laser excitation and/or VUV excitation, we studied experimentally the pulsed conductivity induced by femtosecond VUV pulses, as well as the energy spectra of the photoelectrons released by the same irradiation. The source of irradiation consists in highly coherent VUV pulses obtained through high order harmonic generation of a high intensity femtosecond pulse at a 1.55 eV photon energy (titanium-doped sapphire laser). Harmonics H9 to H17 have been used for photoconductivity (PC) and harmonics H13 to H27 for photoemission experiments (PES). As the photon energy is increased, it is expected that the high energy photoelectrons will generate secondary e-h pairs, thus increasing the excitation density and consequently the PC signal. This is not what we observe : the PC signal first increases for H9 to H13, but then saturates and even decreases. Production of low energy secondary e-h pairs should also be observed in the PES spectrum. In fact we observe very few low energy electrons in the PES spectrum obtained with H13 and H15, despite the sufficient energy of the generated free carriers. At the other end (H21 and above), a very intense low energy secondary electron peak is observed. As a help to interprete such data, we realized the first ab initio calculations of the electronic lifetime of quasiparticles, in the GW approximation in a number of dielectrics including diamond. We find that the results are quite close to a simple "Fermi-liquid" estimation using the electronic density of diamond. We propose that a quite efficient mechanism could be the excitation of plasmons by high energy electrons, followed by the relaxation of plasmons into individual e-h pairs.
Insights into the mechanism of polysaccharide dephosphorylation by a glucan phosphatase (2010)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison (2004)

Large-scale cross-species DNA sequence comparison has become a powerful tool to identify conserved cis-regulatory modules of genes. However, bioinformatic analysis alone cannot reveal how an evolutionarily conserved region regulates gene expression: whether it functions as an enhancer, silencer, or insulator; whether its function is cell-type restricted; and whether biologically relevant transcription factors bind to the element. Here we combine bioinformatics with wet-lab techniques to illustrate a general and systematic method of identifying functional conserved regulatory regions of genes. We applied this approach to the interferon-gamma (IFN-gamma) gene. Comparison of human and mouse IFN-gamma reveals a highly conserved non-coding sequence located approximately 5 kb 5' of the transcription start site. This region coincides with constitutive and inducible DNase I hypersensitivity sites present in IFN-gamma-producing Th1 cells but not in Th2 cells that do not produce IFN-gamma. Histone methylation at the 5' conserved non-coding sequences indicates a more accessible chromatin structure in Th1 cells compared with Th2 cells. This element binds two transcription factors known to be essential for IFN-gamma expression: nuclear factor of activated T cells, an inducible transcription factor, and T-box protein expressed in T cells, a cell lineage-restricted transcription factor. Together, these findings identify a highly conserved distal enhancer in the IFN-gamma cytokine locus and validate our approach as a successful method to detect cis-regulatory elements.
Automatic memory failure analysis using an expert system in conjunction with a memory tester/analyzer (1993)

A methodology by which predictions of memory failure are made prior to manufacturing is presented. Based on these predictions and supporting historical data, expert rules are automatically created and used in conjunction with a memory tester/analyzer to determine the underlying physical causes of particular memory device failures. The histogram of the failure causes for a given lot can be plotted and evaluated. Examples of the application of this methodology to the manufacture of 4-Mb DRAMs are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Disease Activity Score is not suitable as the sole criterion for initiation and evaluation of anti–tumor necrosis factor therapy in the clinic: Discordance between assessment measures and limitations in questionnaire use for regulatory purposes (2005)

The DAS and the physician's assessment of RA activity do not approach, value, and weight RA variables to the same extent, suggesting that RA activity is not evaluated similarly by North American physicians and with the DAS. The scales do not have acceptable levels of concordance. There is too much inherent variability in the DAS and other RA scales (e.g., the Health Assessment Questionnaire) to recommend them as sole determinants of RA activity for clinical or regulatory purposes.
M cell-targeted DNA vaccination (2001)

DNA immunization, although attractive, is poor for inducing mucosal immunity, thus limiting its protective value against most infectious agents. To surmount this shortcoming, we devised a method for mucosal transgene vaccination by using an M cell ligand to direct the DNA vaccine to mucosal inductive tissues and the respiratory epithelium. This ligand, reovirus protein final sigma1, when conjugated to polylysine (PL), can bind the apical surface of M cells from nasal-associated lymphoid tissues. Intranasal immunizations with protein final sigma1-PL-DNA complexes produced antigen-specific serum IgG and prolonged mucosal IgA, as well as enhanced cell-mediated immunity, made evident by elevated pulmonary cytotoxic T lymphocyte responses. Therefore, targeted transgene vaccination represents an approach for enabling DNA vaccination of the mucosa.
High-Performance Liquid Chromatography of Chemical Hybridizing Agent in Wheat (1993)

Abstract A simple HPLC method has been developed for the quantification of chemical hybridizing agent (CHA) in grains, leaves, straw and glumes of traited wheat. The procedure included acido-basic extractions of wheat grains and tissues and derivatization of CHA residue as methyl ester compound. The chromatographic separation was achieved with Spherisorb silica using ethyl acetate-methanol (98:2) and UV detection at 285 nm. Good recoveries of CHA for fortified wheat grains and leaves were obtained. Recoveries of CHA in traited wheat demonstrated accumulation of the agent in reproductive organs.
Estimation of Model Parameters (2013)

This chapter contains sections titled: Estimation is an Inverse Problem The Multivariate Normal Distribution Model of Observations Estimation Conclusion
Unusual and Highly Tunable Missing-Linker Defects in Zirconium Metal–Organic Framework UiO-66 and Their Important Effects on Gas Adsorption (2013)

UiO-66 is a highly important prototypical zirconium metal-organic framework (MOF) compound because of its excellent stabilities not typically found in common porous MOFs. In its perfect crystal structure, each Zr metal center is fully coordinated by 12 organic linkers to form a highly connected framework. Using high-resolution neutron power diffraction technique, we found the first direct structural evidence showing that real UiO-66 material contains significant amount of missing-linker defects, an unusual phenomenon for MOFs. The concentration of the missing-linker defects is surprisingly high, ∼10% in our sample, effectively reducing the framework connection from 12 to ∼11. We show that by varying the concentration of the acetic acid modulator and the synthesis time, the linker vacancies can be tuned systematically, leading to dramatically enhanced porosity. We obtained samples with pore volumes ranging from 0.44 to 1.0 cm(3)/g and Brunauer-Emmett-Teller surface areas ranging from 1000 to 1600 m(2)/g, the largest values of which are ∼150% and ∼60% higher than the theoretical values of defect-free UiO-66 crystal, respectively. The linker vacancies also have profound effects on the gas adsorption behaviors of UiO-66, in particular CO2. Finally, comparing the gas adsorption of hydroxylated and dehydroxylated UiO-66, we found that the former performs systematically better than the latter (particularly for CO2) suggesting the beneficial effect of the -OH groups. This finding is of great importance because hydroxylated UiO-66 is the practically more relevant, non-air-sensitive form of this MOF. The preferred gas adsorption on the metal center was confirmed by neutron diffraction measurements, and the gas binding strength enhancement by the -OH group was further supported by our first-principles calculations.
Structure determination of the macromonomer poly(1,11-dodecadiyne) and its cross-polymerized product (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure determination of the macromonomer poly(1,11-dodecadiyne) and its cross-polymerized productJerome B. Lando and M. ThakurCite this: Macromolecules 1983, 16, 1, 143–146Publication Date (Print):January 1, 1983Publication History Published online1 May 2002Published inissue 1 January 1983https://pubs.acs.org/doi/10.1021/ma00235a027https://doi.org/10.1021/ma00235a027research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Alloy-Free Band Gap Tuning across the Visible Spectrum (2019)

We present evidence, from theory and experiment, that ZnSnN_{2} and MgSnN_{2} can be used to match the band gap of InGaN without alloying-by exploiting cation disorder in a controlled fashion. We base this on the determination of S, the long-range order parameter of the cation sublattice, for a series of epitaxial thin films of ZnSnN_{2} and MgSnN_{2} using three different techniques: x-ray diffraction, Raman spectroscopy, and in situ electron diffraction. We observe a linear relationship between S^{2} and the optical band gap of both ZnSnN_{2} (1.12-1.98 eV) and MgSnN_{2} (1.87-3.43 eV). The results clearly demonstrate the correlation between controlled heterovalent cation ordering and the optical band gap, which applies to a broad group of emerging ternary heterovalent compounds and has implications for similar trends in other material properties besides the band gap.
An improved block equalization scheme for uncertain channel estimation (2007)

We consider the design of a block equalizer for an intersymbol interference channel, given that the channel impulse response is not perfectly known at the receiver. In contrast to other schemes, our receiver is designed for imperfect channel state information and incorporates the statistics of the channel estimation error. In particular, we suggest an error model for data transmission that takes the influence from the data symbols on the estimation noise into account. We derive the optimum detection rule for the considered error model according to the maximum likelihood criterion and verify that the covariance matrix of the estimation noise depends on the actual transmitted data symbols. Motivated by this result, we propose a realizable receiver structure adopting the turbo principle that exploits the data-dependency of the covariance matrix of the estimation noise. The proposed scheme outperforms conventional receivers that neglect the exact statistics of the estimation noise. The core of our receiver is a soft-input soft-output block equalizer based on constrained minimum variance filter design. We assess the performance of the proposed turbo equalization scheme for block Rayleigh fading channels, applying both one-shot training-based channel estimation and iterative data-aided channel estimation
Improving WWW Proxies Performance with Greedy-Dual- Size-Frequency Caching Policy (1998)

WWW proxies, caching policies, replacement algorithms, performance Web proxy caches are used to improve performance of the WWW. Since the majority of Web documents are static documents, caching them at WWW proxies reduces both network traffic and response time. One of the keys to better proxy cache performance is an efficient caching policy which keeps in the cache popular documents and replaces rarely used ones. This paper introduces the Greedy-Dual-Size-Frequency caching policy to maximize hit and byte hit rates for WWW proxies. Proposed caching strategy incorporates
A Hidden Markov Model for Localization Using Low-End GSM Cell Phones (2011)

Research in location determination for GSM phones has gained interest recently as it enables a wide set of location based services. RSSI-based techniques have been the preferred method for GSM localization on the handset as RSSI information is available in all cell phones. Although the GSM standard allows for a cell phone to receive signal strength information from up to seven cell towers, many of today's cell phones are low-end phones, with limited API support, that gives only information about the associated cell tower. In addition, in many places in the world, the density of cell towers is very small and therefore, the available cell tower information for localization is very limited. This raises the challenge of accurately determining the cell phone location with very limited information, mainly the RSSI of the associated cell tower. In this paper we propose a Hidden Markov Model based solution that leverages the signal strength history from only the associated cell tower to achieve accurate GSM localization. We discuss the challenges of implementing our system and present the details of our system and how it addresses the challenges. To evaluate our proposed system, we implemented it on Android-based phones. Results for two different testbeds, representing urban and rural environments, show that our system provides at least 156% enhancement in median error in rural areas and at least 68% enhancement in median error in urban areas compared to current RSSI-based GSM localization systems.
Study of Blood Compatibility with Poly(2-methoxyethyl acrylate). Relationship between Water Structure and Platelet Compatibility in Poly(2-methoxyethylacrylate-<i>co</i>-2-hydroxyethylmethacrylate) (2001)

Previously, we reported that poly(2-methoxyethylacrylate) (PMEA) showed excellent blood compatibility and implied that the water structure in PMEA contributed to the blood compatibility. In this study, the relationship between the water structure and the blood compatibility is clarified by studying the influence of the monomer composition of poly(MEA-co-HEMA) on the water structure and the blood compatibility of the copolymers. The water in the polymer was classified into three types: free water, freezing bound water, and nonfreezing water. The polymers with 0-30 mol % of HEMA content had a significant amount of freezing bound water, and the amount decreases greatly when the composition of HEMA exceeded 30 mol %. On the other hand, the amount of other water increased simply with an increase of HEMA content. The evaluation of the platelet compatibility of poly(MEA-co-HEMA) revealed that the adhesion number and the morphological change of platelet on the copolymer surface were least when the HEMA content was 0-20 mol %. These two results strongly suggest that the freezing bound water relates to the platelet compatibility of the polymers.
Water‐Soluble Phosphanes Derived from 1,3,5‐Triaza‐7‐phosphaadamantane and Their Reactivity towards Gold(I) Complexes (2013)

Abstract New water‐soluble phosphanes derived from 1,3,5‐triaza‐7‐phosphaadamantane, namely, [PTA–R]Br (R = –CH 2 C≡CH, –CH 2 CONH 2 , –CH 2 COOH), are described. Coordination of these phosphanes and their previously reported counterparts (R = –CH 2 CN, –CH 2 Ph and –CH 2 COOMe) to gold(I) salts gives water‐soluble derivatives with chlorido, bromido or pentafluorophenyl coligands. The luminescence properties of all new compounds have been studied in the solid state and compared with the respective free PTA ligands. [PTA–CH 2 Ph]Br, [PTA–CH 2 COOMe]Br and [AuBr(PTA–CH 2 Ph)]Br have also been characterised by X‐ray diffraction analysis. Some of the new gold(I) compounds exhibit strong antiproliferative effects in the human ovarian carcinoma cell line A2780 and its cisplatin‐resistant variant (A2780cisR). A balanced relationship between lipophilicity and hydrophilicity is found in these derivatives, with distribution coefficients (log D 7.4 ) that range from 0.14 to –0.40.
Identification of proteolytic bacteria from the Arctic Chukchi Sea expedition cruise and characterization of cold-active proteases (2014)

Following collection of seawater samples during an Arctic Chukchi Sea expedition cruise of the Korean icebreaker Araon in 2012, a total of 15,696 bacteria were randomly isolated from Marine Broth 2216 agar plates. Of these, 2,526 (16%) showed proteolytic activity and were identified as mainly Alteromonas (31%), Staphylococcus (27%), and Pseudoalteromonas (14%). Among the proteolytic strains, seven were selected based on their significant ability to grow and produce a halo on skim milk plates at low temperatures (<5°C) owing to cold-active proteases. These strains were affiliated with the genus Pseudoalteromonas and were divided into three groups based on phylogenetic analysis of the 16S rRNA genes. Profiling cell membrane fatty acids confirmed the 16S rRNA-based differentiation and revealed the accordance between the two analyses. Seven genes for serine protease precursors were amplified from the corresponding strains, and based on sequence similarities, these genes were divided into three groups that were identical to those identified by the 16S rRNA phylogenetic analysis. Three protease genes from the representative strains of each group were composed of 2,127-2,130 bp, encoding 708-709 amino acids, and these genes yielded products with calculated molecular weights of approximately 72.3-72.8 kDa. Amino acid sequence analysis suggested that the precursors are members of the subtilase serine endo- and exo-peptidase clan and contain four domains (signal peptide, N-terminal prosequence, catalytic domain, and two pre-peptidase C-terminal domains). Upon expression in E. coli, each recombinant protease exhibited proteolytic activity on zymogram gels.
Measurement of Ocular Fundus Pulsation in Healthy Subjects Using a Novel Fourier-Domain Optical Coherence Tomography (2011)

The technique described here is useful for a precise description of FPA and the movement of ocular tissues. Further investigations and technical improvements will be beneficial for understanding the role of choroidal pulsation in the pathophysiology of ocular diseases.
Development of a methodology for monitoring and prediction of road surface conditions in highly automated driving (2017)

This paper addresses vertical dynamics comfort in Highly Automated Driving (HAD). Based on the assumption that a reduction of vertical acceleration inputs will result in increased passenger comfort, we develop an approach to minimize the effect of road surface anomalies on HAD users. We propose a participative method to identify, process and distribute road quality data using a plurality of vehicles exchanging information with a central server. By activating automated responses to warn about, avoid or counteract the appearance of any type of discomfort prompted by vertical vibrations, we strive to increase the maturity of HAD technology.
Techniques in handling load regulating problems (1953)

RECENT UNPRECEDENTED load growth has stimulated parallel operation to such an extent that there are now only six major interconnections in the United States. The operation of these vast grids has brought two major problems into sharp focus: 1. Permissible scheduled loading on critical arterial tie lines is being reduced by the use of increasingly large cyclic swings. 2. Appreciable savings are being lost by the inability of operating personnel to maintain the loading on an increasing number of stations and units in accordance with incremental costs.
Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension (2005)

Inhibition of the type 5 phosphodiesterase and inhibition of Rho kinase are both effective in reducing pulmonary hypertension (PH). Here we investigate whether Rho kinase inhibition is involved in the beneficial effect of the type 5 phosphodiesterase inhibitor sildenafil on PH. Chronic hypoxia-induced PH in rats is associated with an increase in RhoA activity in pulmonary artery that was maximal after 2 days (10.7+/-0.9-fold increase, n=6, P<0.001). The activity of Rho kinase assessed by measuring the level of myosin phosphatase target subunit 1 (MYPT1) phosphorylation was also increased (5.7+/-0.8-fold over control, n=8). Chronic fasudil (30 mg kg(-1) day(-1); 14 days) and sildenafil (25 mg kg(-1) day(-1); 14 days) treatments reduced PH and pulmonary cardiovascular remodelling, and inhibited the MYPT1 phosphorylation in pulmonary artery from hypoxic rats by 82.3+/-3% (n=4) and by 76.6+/-2% (n=4), respectively. The inhibitory effect of sildenafil (10 microM) on MYPT1 phosphorylation was demonstrated by the loss of actin stress fibres in vascular smooth muscle cells. However, in vitro kinase assays indicated that sildenafil had no direct inhibitory action on Rho kinase activity. Sildenafil treatment induced increased RhoA phosphorylation and association to its cytosolic inhibitory protein, guanine dissociation inhibitor (GDI) in pulmonary artery.We propose that sildenafil inhibits RhoA/Rho kinase-dependent functions in pulmonary artery through enhanced RhoA phosphorylation and cytosolic sequestration by GDI. The inhibition of intracellular events downstream of RhoA thus participates in the beneficial effect of sildenafil on PH.