gebhart/patrepeval huggingface dataset:
Multi-Path Region Mining For Weakly Supervised 3D Semantic Segmentation on Point Clouds (2020)

Point clouds provide intrinsic geometric information and surface context for scene understanding. Existing methods for point cloud segmentation require a large amount of fully labeled data. Using advanced depth sensors, collection of large scale 3D dataset is no longer a cumbersome process. However, manually producing point-level label on the large scale dataset is time and labor-intensive. In this paper, we propose a weakly supervised approach to predict point-level results using weak labels on 3D point clouds. We introduce our multi-path region mining module to generate pseudo point-level label from a classification network trained with weak labels. It mines the localization cues for each class from various aspects of the network feature using different attention modules. Then, we use the point-level pseudo labels to train a point cloud segmentation network in a fully supervised manner. To the best of our knowledge, this is the first method that uses cloud-level weak labels on raw 3D space to train a point cloud semantic segmentation network. In our setting, the 3D weak labels only indicate the classes that appeared in our input sample. We discuss both scene- and subcloud-level weakly labels on raw 3D point cloud data and perform in-depth experiments on them. On ScanNet dataset, our result trained with subcloud-level labels is compatible with some fully supervised methods.
Electrostatics and the electro-optic behaviour of chiral smectics C: 'block' polarization screening of applied voltage and 'V-shaped' switching (2000)

We present a new model for the physics of thresholdless switching in chiral smectics. In the limit of high polarization, the electro-optics of chiral smectic C liquid crystals are dominated by two distinct electrostatic effects. Complete (surface to surface) 'stiffening' of the polarization field by its charge self-interaction causes the polarization to orient as a uniform block. Complete screening of applied electric field by polarization charge leads to voltage-induced orientation where the electric field in the liquid crystal is exactly zero, These effects, both operative during the 'V-shaped' portion of thresholdless transmission vs. voltage curves, combine to produce 'V-shaped' switching.
Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy (2013)

The hallmarks of Alzheimer's disease (AD) are the aggregates of amyloid-β (Aβ) peptides and tau protein. Autophagy is a major cellular pathway leading to the removal of aggregated proteins. We have reported recently that autophagy was responsible for amyloid precursor protein cleaved C-terminal fragment (APP-CTF) degradation and amyloid β clearance in an Atg5-dependent manner. Here we aimed to elucidate the molecular mechanism by which autophagy mediates the degradation of APP-CTF and the clearance of amyloid β. Through affinity purification followed by mass spectrum analysis, we identified adaptor protein (AP) 2 together with phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) as binding proteins of microtubule-associated protein 1 light chain 3 (LC3). Further analysis showed that AP2 regulated the cellular levels of APP-CTF. Knockdown of AP2 reduced autophagy-mediated APP-CTF degradation. Immunoprecipitation and live imaging analysis demonstrated that AP2 and PICALM cross-link LC3 with APP-CTF. These data suggest that the AP-2/PICALM complex functions as an autophagic cargo receptor for the recognition and shipment of APP-CTF from the endocytic pathway to the LC3-marked autophagic degradation pathway. This molecular mechanism linking AP2/PICALM and AD is consistent with genetic evidence indicating a role for PICALM as a risk factor for AD.
Real-time error detection using a laser diode array optical head (1985)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Itoh, H. Kawano, S. Shimonou, and T. Yoshiura, "Real-time error detection using a laser diode array optical head," in Conference on Lasers and Electro-Optics, A. Gara, C. Giuliano, D. Auston, and R. Jacobs, eds., OSA Technical Digest (Optica Publishing Group, 1985), paper WM48. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Photoactivation of the nematicidal compound alpha-terthienyl from roots of marigolds (Tagetes species). A possible singlet oxygen role. (1979)

The nematicidal compound alpha-terthienyl from roots of Tagetes species generates upon irradiation with near ultraviolet light reactive oxygen species on which the in vitro nematicidal activity depends. This system was studied by following the inhibition of glucose-6-phosphate dehydrogenase by photoactivated alpha-terthienyl and protection of the enzyme activity in the absence of oxygen and by various additions. Addition of mannitol, benzoate, superoxide dismutase or catalase did not have any effect nor did H2O2. This suggests that OH., O-.2, and H2O2 are not the reactive oxygen species involved. The enzyme was protected against photoactivated alpha-terthienyl in air-saturated solutions by singlet oxygen quenchers such as histidine, methionine, tryptophan, bovine serum albumin, and NaN3. Furthermore, inactivation of the enzyme was about 3.5 times faster in D2O than in H2O. When alpha-terthienyl in CH2Cl2 was irradiated in the presence of the olefin adamantylideneadamantane, a stable dioxetane was formed which decomposed to adamantanone when heated above its melting point. These results indicate a singlet oxygen-mediated process.
Erythropoietin receptor. Subunit structure and activation. (1990)

Physiologic role oferythropoietin in erythroid differentiation Erythropoietin (EPO)' is a 34-kD glycoprotein hormone which is the primary regulator of human erythropoiesis. A cDNA encoding EPO has been isolated (1), and recombinant EPO with oligosaccharide moieties identical to the natural ma- terial is available (2). EPO is synthesized and released by the kidney, and it circulates to the bone marrow where it stimu- lates resident erythroid progenitors via a specific receptor (3). EPO as a pharmacologic agent has clearly demonstrated effi- cacy in anemic states such as kidney failure (4, 5). In vivo, EPO causes a rapid rise in hematocrit in 7-10 d.
Robust tracking control of Stewart platform (2002)

We propose robust tracking controllers for a Stewart platform in the presence of uncertainty. These schemes are based on a Lyapunov approach. Even if a Stewart platform system has a similarity in structure to a serial robot the tracking control problem needs a different form compared to a serial robot. We propose controllers designed both in Cartesian coordinates and in actuator coordinates. The controllers based either on Cartesian or on actuator coordinates have features respectively. The proposed controllers guarantee practical stability.
Calculation of the vibrationally non-relaxed photo-induced electron transfer rate constant in dye-sensitized solar cells (2007)

In this paper we shall show how to calculate the single vibronic-level electron-transfer rate constant, which will be compared with the thermal averaged one. To apply the theoretical results to the dye-sensitized solar cells, we use a simple model to describe how we model the final state of the electron-transfer process. Numerical calculations will be performed to demonstrate the theoretical results.
Room temperature operation of a quantum-dot flash memory (1997)

A flash-memory device has been fabricated and demonstrated at room temperature by coupling a self-aligned, sub-50-nm quantum dot to the channel of a transistor on a silicon-on-insulator (SOI) substrate. Large threshold voltage shifts of up to 0.75 V are obtained for small erase/write voltages (13 V) at room temperature. At 90 K, evidence of single electron storage is observed. The small size of this device is attractive for achieving high packing densities, while the relatively large output current (100 nA-μA's), low off-state current (10 pA), and simple fabrication, requiring only minor variations in standard processing, make it suitable for integration with current silicon memory and logic technology.
Application of the mutual information criterion for feature selection in computer‐aided diagnosis (2001)

The purpose of this study was to investigate an information theoretic approach to feature selection for computer-aided diagnosis (CAD). The approach is based on the mutual information (MI) concept. MI measures the general dependence of random variables without making any assumptions about the nature of their underlying relationships. Consequently, MI can potentially offer some advantages over feature selection techniques that focus only on the linear relationships of variables. This study was based on a database of statistical texture features extracted from perfusion lung scans. The ultimate goal was to select the optimal subset of features for the computer-aided diagnosis of acute pulmonary embolism (PE). Initially, the study addressed issues regarding the approximation of MI in a limited dataset as it is often the case in CAD applications. The MI selected features were compared to those features selected using stepwise linear discriminant analysis and genetic algorithms for the same PE database. Linear and nonlinear decision models were implemented to merge the selected features into a final diagnosis. Results showed that the MI is an effective feature selection criterion for nonlinear CAD models overcoming some of the well-known limitations and computational complexities of other popular feature selection techniques in the field.
Novel High-Density Low-Power Logic Circuit Techniques Using DG Devices (2005)

Novel high-density low-power double-gate circuit techniques for basic logic families such as NAND, NOR, and pass-gate are proposed. The technique exploits the independent front- and back-gate bias to reduce the number of transistors for implementing logic functions. The scheme substantially improves the standby and dynamic power consumptions by reducing the number of transistors and the chip area/size while improving the circuit performance. The power/performance advantages are analyzed/validated via mixed-mode two-dimensional MEDICI numerical device simulations, as well as by using physical delay equations.
<i>Escherichia coli</i> dihydrodipicolinate synthase. Identification of the active site and crystallization (1992)

Escherichia coli dihydrodipicolinate synthase (DHDPS) (EC 4.2.1.52), the first enzyme unique to lysine biosynthesis, catalyses the condensation of pyruvate and aspartate beta-semialdehyde (ASA) by a ping-pong mechanism. Pyruvate binds first to the enzyme, forming a Schiff base with the epsilon-amino group of Lys-161, followed by binding of ASA. Km values of 0.57 and 0.55 mM were determined for pyruvate and DL-ASA respectively. 3-Bromopyruvate inhibits DHDPS with a Ki of 1.6 mM. DHDPS is 50% inhibited by 1.0 mM-L-lysine, 1.2 mM-sodium dipicolinate or 4.6 mM-S-2-aminoethyl-L-cysteine. Crystals of DHDPS diffracting to beyond a resolution of 0.24 nm (2.4 A) were obtained under several experimental conditions. Diffraction patterns were compatible with trigonal space groups P3(1)21 or P3(2)21, with unit-cell parameters a = b = 12.26 nm and c = 11.19 nm. The density of the crystals indicates the presence of a dimer of DHDPS subunits per asymmetric unit.
The Relationship Between Direct‐Care RN Specialty Certification and Surgical Patient Outcomes (2014)

Specialty certification enhances patient safety in health care by validating that practice is consistent with standards of excellence. The purpose of this research was to explore the relationship between direct-care, specialty-certified nurses employed in perioperative units, surgical intensive care units (SICUs), and surgical units and nursing-sensitive patient outcomes in SICUs and surgical units. Lower rates of central-line-associated bloodstream infections in SICUs were significantly associated with higher rates of CPAN (certified postanesthesia nurse) (β = -0.09, P = .05) and CNOR/CRNFA (certified nurse operating room/certified RN first assistant) (β = -0.17, P = .00) certifications in perioperative units. Unexpectedly, higher rates of CNOR/CRNFA certification in perioperative units were associated with higher rates of hospital-acquired pressure ulcers (β = 0.08, P = .03) and unit-acquired pressure ulcers (β = 0.13, P = .00), possibly because of a higher risk of pressure ulcers in the patient population. Additional research is needed to clarify this relationship. Our findings lend credence to perioperative, SICU, and surgical nurses participating in lifelong learning and continuous professional development, including achievement of specialty certification.
Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages. (1996)

The presence of oxysterols in macrophages isolated from atherosclerotic tissue and the effect of oxysterols on the regulation of lipoprotein lipase (LPL) mRNA were studied. Both rabbit and human macrophages, freshly isolated from atherosclerotic aorta, show about the same distribution of oxysterols, analyzed by isotope dilution mass spectrometry, except that all three preparations of human arterial-derived macrophages contained high levels of 27-hydroxycholesterol, which was not found in rabbit macrophages. To determine if oxysterols regulate LPL expression, human monocyte-derived macrophages were incubated with different oxysterols. Incubation with 7 beta-hydroxycholesterol and 25-hydroxycholesterol resulted in a 70-75% reduction of LPL mRNA, analyzed by quantitative RT-PCR. Cholesterol and other tested oxysterols showed no effect on macrophage LPL mRNA expression compared with control. LPL activity in the medium was also reduced after exposure of the macrophages to 7 beta-hydroxycholesterol and 25-hydroxycholesterol. In conclusion, we have demonstrated accumulation of oxysterols in macrophage-derived foam cells isolated from atherosclerotic aorta. There was suppression of LPL mRNA in human monocyte-derived macrophages after incubation with 7 beta-hydroxycholesterol and 25-hydroxycholesterol. It is tempting to suggest that an exposure to oxysterols may explain our earlier observation of a low level of LPL mRNA in arterial foam cells.
Left atrial appendage aneurysm: correlation of noninvasive with clinical and surgical findings: report of a case. (1975)

Congenital left atrial appendage aneurysm is rarely diagnosed on the basis of an abnormal cardiac silhouette. Patients with a left atrial appendage aneurysm often present with symptoms of systemic emboli or supraventricular arrhythmias. A patient with left atrial appendage aneurysm was diagnosed by correlation of two noninvasive techniques echocardiography and radionuclide scintiscanning. Angiography was confirmatory and aneurysmectomy was successfully performed.
The effects of InP grown by He-plasma assisted epitaxy on quantum-well intermixing (2001)

He-plasma assisted InP (He*-InP) layers grown by gas source molecular beam epitaxy (GSMBE) have been employed to enhance quantum well (QW) intermixing induced by rapid thermal annealing in a 1.5 /spl mu/m InGaAsP QW laser structure. Inserting a 40 nm He*-InP layer just above the active region enhances the blue-shift for anneal temperatures larger than 680/spl deg/C, and a 42 nm additional blue-shift is obtained at 750/spl deg/C for samples with the He*InP layer, compared to samples with normal InP replacing the He*-InP. This is accompanied by a reduction in the photoluminescence (PL) intensity for anneal temperatures greater than 600/spl deg/C and is attributed to the migration of nonradiative defects from the He*-InP layer into the QWs. Insertion of a thin InGaAs layer between the He*-InP layer and the QW blocks the diffusion of these nonradiative defects into the QW. The results indicate that the He*-InP material could prove useful in QW intermixing to achieve integrated optoelectronic devices, in particular for high-frequency devices which require short carrier lifetimes.
Prospective Multicenter Study of the Impact of Oncotype DX Colon Cancer Assay Results on Treatment Recommendations in Stage II Colon Cancer Patients (2014)

The Oncotype DX colon cancer assay is a clinically validated predictor of recurrence risk in stage II colon cancer patients. This prospective study evaluated the impact of recurrence score (RS) results on physician recommendations regarding adjuvant chemotherapy in T3, mismatch repair-proficient (MMR-P) stage II colon cancer patients. Patients and Methods. Stage IIA colon cancer patients were enrolled in 17 centers. Patient tumor specimens were assessed by the RS test (quantitative reverse transcription-polymerase chain reaction) and mismatch repair (immunohistochemistry). For each patient, the physician's recommended postoperative treatment plan of observation, fluoropyrimidine monotherapy, or combination therapy with oxaliplatin was recorded before and after the RS and mismatch repair results were provided. Results. Of 221 enrolled patients, 141 patients had T3 MMR-P tumors and were eligible for the primary analysis. Treatment recommendations changed for 63 (45%; 95% confidence interval: 36%-53%) of these 141 T3 MMR-P patients, with intensity decreasing for 47 (33%) and increasing for 16 (11%). Recommendations for chemotherapy decreased from 73 patients (52%) to 42 (30%), following review of RS results by physician and patient. Increased treatment intensity was more often observed at higher RS values, and decreased intensity was observed at lower values (p = .011). Conclusion. Compared with traditional clinicopathological assessment, incorporation of the RS result into clinical decision making was associated with treatment recommendation changes for 45% of T3 MMR-P stage II colon cancer patients in this prospective multicenter study. Use of the RS assay may lead to overall reduction in adjuvant chemotherapy use in this subgroup of stage II colon cancer patients.
1-Alkyl-benzotriazole-5-carboxylic Acids Are Highly Selective Agonists of the Human Orphan G-Protein-Coupled Receptor GPR109b (2006)

1-Substituted benzotriazole carboxylic acids have been identified as the first reported examples of selective small-molecule agonists of the human orphan G-protein-coupled receptor GPR109b (HM74), a low-affinity receptor for the HDL-raising drug niacin. No activity was observed at the highly homologous high-affinity niacin receptor GPR109a (HM74A). The high degree of selectivity was attributed to a difference in the amino acid sequence adjacent to a key arginine-ligand interaction allowing somewhat larger ligands to be tolerated by GPR109b.
Spherical gradient-index lenses as perfect imaging and maximum power transfer devices (2000)

Gradient-index lenses can be viewed from the perspectives of both imaging and nonimaging optics, that is, in terms of both image fidelity and achievable flux concentration. The simple class of gradient-index lenses with spherical symmetry, often referred to as modified Luneburg lenses, is revisited. An alternative derivation for established solutions is offered; the method of Fermat's strings and the principle of skewness conservation are invoked. Then these nominally perfect imaging devices are examined from the additional vantage point of power transfer, and the degree to which they realize the thermodynamic limit to flux concentration is determined. Finally, the spherical gradient-index lens of the fish eye is considered as a modified Luneburg lens optimized subject to material constraints.
Indentability of Conventional and Negative Poisson's Ratio Foams (1993)

The indentation resistance of foams, both of conventional structure and of a novel re-entrant structure giving rise to negative Poisson's ratio, was studied using holo graphic interferometry. In holographic indentation tests, re-entrant foams had higher yield strengths σ y and lower stiffness E than conventional foams of the same original relative density. Damage in both kinds of foam occurred primarily directly under the indenter. Calculated energy absorption for dynamic impact is considerably higher for re-entrant foam than conventional foam
Rice Plant Development: from Zygote to Spikelet (2005)

Rice is becoming a model plant in monocotyledons and a model cereal crop. For better understanding of the rice plant, it is essential to elucidate the developmental programs of the life cycle. To date, several attempts have been made in rice to categorize the developmental processes of some organs into substages. These studies are based exclusively on the morphological and anatomical viewpoints. Recent advancement in genetics and molecular biology has given us new aspects of developmental processes. In this review, we first describe the phasic development of the rice plant, and then describe in detail the developmental courses of major organs, leaf, root and spikelet, and specific organs/tissues. Also, for the facility of future studies, we propose a staging system for each organ.
Online convergence detection for evolutionary multi-objective algorithms revisited (2010)

The design and application of termination criteria has become an important aspect in evolutionary multi-objective optimization. Online convergence detection (OCD) determines when further generations are no longer promising based on statistical tests on a set of performance indicators. The behavior of OCD mainly depends on two parameters, the number of preceding generations considered in the statistical tests and the desired variance limit. In this paper, guidelines for selecting appropriate combinations of these parameters are empirically derived based on design-of-experiment methods. Furthermore, a variant of OCD is introduced which directly operates on the hypervolume indicator - the internal measure of the SMS-EMOA. This allows a separated analysis of the variance criterion and reduces the complexity of OCD. Based on the experimental design, a systematic comparison with the classical OCD approach is performed and differences between the appropriate parameterizations of both variants are highlighted.
Evidence for the Presence of Specific Receptors for NFormyl Chemotactic Peptides on Human Spermatozoa (1986)

Synthetic N-formylated peptides are potent chemoattractants for human spermatozoa in vitro. The specific structure-activity relations for eliciting a chemotactic response and the ability of the antagonist tertbutoxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl- phenylalanine (Boc-Phe-Leu-Phe-Leu-Phe) to inhibit the chemotaxis induced by these peptides strongly suggest the presence of receptors on human spermatozoa. The following studies were performed to identify specific binding sites on human spermatozoa by using [35S]-N-formyl-methionyl-leucyl-phenylalanine [( 35S]f-Met-Leu-Phe), a potent chemotactic peptide. Binding of the [35S]formyl-peptide to human spermatozoa was rapid (t1/2, 8 min) and reversible. Binding isotherms of the saturation experiments revealed a single class of high affinity, low capacity binding sites (equilibrium dissociation constant, 17.7 nM; maximal binding, 109 fmol/2 X 10(6) cells) and an average number of 60,000 receptors per cells. The biological potencies of a series of formyl peptides as chemoattractants correlated closely with their relative abilities to compete with [35S]f-Met-Leu-Phe for specific binding to human spermatozoa. These data fulfill the major criteria for demonstration of specific receptors for chemotactic peptides on human spermatozoa. It is likely that these receptor sites initiate the chemotactic response of human spermatozoa to N-formyl peptides.