gebhart/patrepeval huggingface dataset:
Serine Protease Catalysis: A Computational Study of Tetrahedral Intermediates and Inhibitory Adducts (2016)

Peptide boronic acids and peptidyl trifluoromethyl ketones (TFKs) inhibit serine proteases by forming monoanionic, tetrahedral adducts to serine in the active sites. Investigators regard these adducts as analogs of monoanionic, tetrahedral intermediates. Density functional theory (DFT) calculations and fractional charge analysis show that tetrahedral adducts of model peptidyl TFKs are structurally and electrostatically very similar to corresponding tetrahedral intermediates. In contrast, the DFT calculations show the structures and electrostatic properties of analogous peptide boronate adducts to be significantly different. The peptide boronates display highly electrostatically positive boron, with correspondingly negative ligands in the tetrahedra. In addition, the computed boron-oxygen and boron-carbon bond lengths in peptide boronates (which are identical or very similar to the corresponding bonds in a peptide boronate adduct of α-lytic protease determined by X-ray crystallography at subangstrom resolution) are significantly longer than the corresponding bond lengths in model tetrahedral intermediates. Since protease-peptidyl TFKs incorporate low-barrier hydrogen bonds (LBHBs) between an active site histidine and aspartate, while the protease-peptide boronates do not, these data complement the spectroscopic and chemical evidence for the participation of LBHBs in catalysis by serine proteases. Moreover, while the potency of these classes of inhibitors can be correlated to the structures of the peptide moieties, the present results indicate that the strength of their bonds to serine contribute significantly to their inhibitory properties.
Improvement of clinical pregnancy rate and implantation rate of in-vitro fertilization—embryo transfer patients by using methylprednisone (1993)

A prospective non-randomized study was undertaken to test whether immunosuppression improves implantation and pregnancy rates in an in-vitro fertilization-embryo transfer (IVF-ET) programme in patients with tubal factor infertility. Treatment involved ovarian stimulation, transvaginal oocyte retrieval, IVF-ET, and assessment of short-term administration of large doses of corticosteroids (60 mg of methyl-prednisone x 4 days). When compared to the group that did not receive immunosuppressive doses of methylprednisone (group A; mean age 31.85 +/- 4.09 years), those subjects who were treated (group A2) showed a statistically significant increase in pregnancy (P < 0.01) and take home baby rate (P < 0.01). Similar results were observed in subjects who received corticosteroids in their first IVF-ET attempt (group B; mean age 34.32 +/- 4.98 years). Our results suggest that immunosuppressive doses of corticosteroids administered for a short period of time to patients undergoing IVF-ET could significantly improve the implantation and pregnancy rates. Possible mechanisms of action of corticosteroids are proposed.
Audibility of a CD-Standard A/D/A Loop Inserted into High-Resolution Audio Playback* (2007)

Claims both published and anecdotal are regularly made for audibly superior sound quality for two-channel audio encoded with longer word lengths and/or at higher sampling rates than the 16-bit/44.1-kHz CD standard. The authors report on a series of double-blind tests comparing the analog output of high-resolution players playing high-resolution recordings with the same signal passed through a 16-bit/44.1-kHz bottleneck. The tests were conducted for over a year using different systems and a variety of subjects. The systems included expensive professional monitors and one high-end system with electrostatic loudspeakers and expensive components and cables. The subjects included professional recording engineers, students in a university recording program, and dedicated audiophiles. The test results show that the CD-quality A/D/A loop was undetectable at normal-to-loud listening levels, by any of the subjects, on any of the playback systems. The noise of the CD-quality loop was audible only at very elevated levels.
Mechanism of the silicide-catalysed hydrodehalogenation of silicon tetrachloride to trichlorosilane (1996)

A mechanism of transition metal silicide-catalysed hydrodehalogenation of silicon tetrachloride to trichlorosilane is proposed. The overall reaction includes electron transfer steps from the metal silicide catalyst to adsorbed silicon tetrachloride molecules. A silylene species (SiCl2), which is formed from SiCl4 and the catalyst surface, is proposed. A hydrogen molecule injects electrons into the solid, whereby hydrogen chloride is generated on the surface. Trichlorosilane results from the oxidative addition of HCl to chemisorbed SiCl2.
Treatment of Hepatitis C with Milk Thistle? (2001)

In a hypothetical case, a 35-year-old female presents to the pharmacy for a refill of her prescription oral contraceptive. She also asks about taking milk thistle. She states that several members of her “liver disease support group” are using the herbal supplement. She has recently been diagnosed with chronic hepatitis C and is currently receiving interferon alfa-2b and ribivarin. Her past history is significant for illegal drug and alcohol abuse in her early twenties.
Optimization of energy generation in wind farm through fuzzy control (2004)

Wind farms are energy generation systems being autonomous and controllable generating units. At current technological status, each set turbine-generator-power converter should be considered as a unit. These units work as an individual system for variable speed systems. Variable speed wind systems demand for an appropriate control of operating point at different wind regimens as well they can operate at different rotational speed and, consequently, at different system efficiency. Control characteristics of each machine are based on associated power converter that implements control on power flow to the grid. In the paper, authors discuss the design of the controller for the wind farm. The approach is based on the development of a fuzzy controller for the entire farm. So an appropriate structure and rules of inference allow at optimizing the operation characteristics of the farm. The paper demonstrates the demanding for a whole wind farm controller and discusses some results carried out in the development of a fuzzy controller that optimizes total generated power of a wind farm, persecuting the goal of a good quality generated power.
High pressure angle-dispersive Brillouin spectroscopy: A technique for determining acoustic velocities and attenuations in liquids and solids (2002)

We report the combination of a high-pressure sample chamber and a stable, nonscanning, angle-dispersive Fabry–Perot interferometer allowing the rapid measurement of inelastic light scattering from acoustic phonon modes in solid and liquid samples at high pressure. The primary components of the apparatus are a (i) narrow frequency gas ion laser, (ii) a solid or air-spaced etalon, (iii) a multichannel charge coupled device detector, and (iv) a large volume, high-pressure cell. The fundamental principle of this spectrometer is based on the angular dispersion of light through an etalon, whereupon the multiple-order frequency dispersed spectrum can be acquired with an array detector. Typical acquisition times are less than 1 s using low to moderate laser power.
An effective dynamic analysis for detecting generalized deadlocks (2010)

We present an effective dynamic analysis for finding a broad class of deadlocks, including the well-studied lock-only deadlocks as well as the less-studied, but no less widespread or insidious, deadlocks involving condition variables. Our analysis consists of two stages. In the first stage, our analysis observes a multi-threaded program execution and generates a simple multi-threaded program, called a trace program, that only records operations observed during the execution that are deemed relevant to finding deadlocks. Such operations include lock acquire and release, wait and notify, thread start and join, and change of values of user-identified synchronization predicates associated with condition variables. In the second stage, our analysis uses an off-the-shelf model checker to explore all possible thread interleavings of the trace program and check if any of them deadlocks. A key advantage of our technique is that it discards most of the program logic which usually causes state-space explosion in model checking, and retains only the relevant synchronization logic in the trace program, which is sufficient for finding deadlocks. We have implemented our analysis for Java, and have applied it to twelve real-world multi-threaded Java programs. Our analysis is effective in practice, finding thirteen previously known as well as four new deadlocks.
Fast HEVC intra prediction mode decision based on EDGE direction information (2012)

The High Efficiency Video Coding (HEVC) is an emerging standard that achieves higher encoding efficiency when compared to previous standards such as H.264/AVC. One key contributor to this improvement is the new intra prediction method that supports a large number of prediction directions at a cost of very high computational complexity. This paper presents a fast intra prediction mode decision algorithm, which instead of taking into account only the modes of the neighbor PUs (prediction units) uses edge information of the current PU to choose a reduced set of directions from which the best prediction mode (direction) is finally selected. The proposed method provides a decrease of up to 32.08% in the HEVC intra prediction processing time, with a little increase in the bit-rate (0.9% on average) and a negligible reduction in PSNR values.
Luminescent metal complexes. Part 5. Luminescence properties of ring-substituted 1,10-phenanthroline tris-complexes of ruthenium(II) (1985)

The absorption characteristics, emission spectra, luminescent quantum yields, and lifetimes are reported for 24 ruthenium(II) tris-1,10-phenanthroline complexes in EtOH–MeOH solution. Quantum yields fall between 0.019 and 0.403, the highest values being recorded for complexes substituted at the 4,7-sites with aryl groups. Incorporation of these derivatives into poly(vinyl chloride) film raises the quantum yields leading to values ranging from 0.40 to 0.75.
Epithelial-macrophage interactions determine pulmonary fibrosis susceptibility in Hermansky-Pudlak syndrome (2016)

Alveolar epithelial cell (AEC) dysfunction underlies the pathogenesis of pulmonary fibrosis in Hermansky-Pudlak syndrome (HPS) and other genetic syndromes associated with interstitial lung disease; however, mechanisms linking AEC dysfunction and fibrotic remodeling are incompletely understood. Since increased macrophage recruitment precedes pulmonary fibrosis in HPS, we investigated whether crosstalk between AECs and macrophages determines fibrotic susceptibility. We found that AECs from HPS mice produce excessive MCP-1, which was associated with increased macrophages in the lungs of unchallenged HPS mice. Blocking MCP-1/CCR2 signaling in HPS mice with genetic deficiency of CCR2 or targeted deletion of MCP-1 in AECs normalized macrophage recruitment, decreased AEC apoptosis, and reduced lung fibrosis in these mice following treatment with low-dose bleomycin. We observed increased TGF-β production by HPS macrophages, which was eliminated by CCR2 deletion. Selective deletion of TGF-β in myeloid cells or of TGF-β signaling in AECs through deletion of TGFBR2 protected HPS mice from AEC apoptosis and bleomycin-induced fibrosis. Together, these data reveal a feedback loop in which increased MCP-1 production by dysfunctional AECs results in recruitment and activation of lung macrophages that produce TGF-β, thus amplifying the fibrotic cascade through AEC apoptosis and stimulation of fibrotic remodeling.
Stimulation and inhibition of interferon-.BETA. production of human diploid fibroblasts by foodstuffs. (1991)

We screened for foodstuffs affecting interferon-β (IFN-β) production of human foreskin diploid fibroblasts, in the presence of poly I poly C, cycloheximide, and actinomycin D. α- and β-caseins stimulated IFN-β production dose-dependently, but κ-casein inhibited it. Of the two chymosin fragments of κ-casein, glycomacropeptide was an inhibitor but p-κ-casein was not. β-lactoglobulin stimulated IFN-β production weakly, but lactoferrin inhibited it strongly. It was also shown that serum contained some factors inhibiting IFN-β induction and stimulating its production.
An Ensemble Architecture for Learning Complex Problem-Solving Techniques from Demonstration (2012)

We present a novel ensemble architecture for learning problem-solving techniques from a very small number of expert solutions and demonstrate its effectiveness in a complex real-world domain. The key feature of our “Generalized Integrated Learning Architecture” (GILA) is a set of heterogeneous independent learning and reasoning (ILR) components, coordinated by a central meta-reasoning executive (MRE). The ILRs are weakly coupled in the sense that all coordination during learning and performance happens through the MRE. Each ILR learns independently from a small number of expert demonstrations of a complex task. During performance, each ILR proposes partial solutions to subproblems posed by the MRE, which are then selected from and pieced together by the MRE to produce a complete solution. The heterogeneity of the learner-reasoners allows both learning and problem solving to be more effective because their abilities and biases are complementary and synergistic. We describe the application of this novel learning and problem solving architecture to the domain of airspace management, where multiple requests for the use of airspaces need to be deconflicted, reconciled, and managed automatically. Formal evaluations show that our system performs as well as or better than humans after learning from the same training data. Furthermore, GILA outperforms any individual ILR run in isolation, thus demonstrating the power of the ensemble architecture for learning and problem solving.
The Easy Disruption of the β-Sheet Structure of Resin-Bound Human Proinsulin C-Peptide Fragments by Strong Electron-Donor Solvents (1989)

Abstract The β-sheet structure disruption of cross-linked polystyrene resin-bound human proinsulin C-peptide fragments containing Pro residues at suitable intervals was investigated by a solvent titration method in CH2Cl2, mainly using TFE and HMPA as titrating solvents. The easy disruption of the β-sheet structure of resin-bound peptides in CH2Cl2 by TFE and HMPA strongly suggested that the concept of “the peptide segment separation by tertiary peptide bonds” was useful for estimating the β-sheet-structure-disrupted behavior and that the β-sheet structure of the protected peptides having high 〈Pc〉 values could easily be disrupted in a medium electron-acceptor solvent of CH2Cl2 by the addition of a strong electron-donor solvent of HMPA in spite of the electron donor-acceptor interaction between solvents. The present results indicate that effective solvents for solid-phase peptide synthesis by a fragment condensation procedure should be searched by taking the average helix, β-sheet, and coil conformation values, 〈Pα〉, 〈Pβ〉, and 〈Pc〉, of peptide segments into consideration.
Optical recognition of hand-printed characters of any size, position, and orientation (1992)

This paper deals with the optical recognition of text data in documents such as engineering drawings, land-use and land-register maps, and utility maps. The automatic computer acquisition of these documents is performed through the basic steps of vectorization of the line-structure and recognition of the text data interspersed in the document. The latter data are usually handwritten by professional draftsmen, and may have any size, position, and orientation. We review some of the features appropriate to this particular OCR problem, and suggest a special recognition strategy. Numerous examples are given. The results obtained with a prototype system on actual land-register maps are reported.
Introduction (2010)

et de quelque manire que ce soit, est interdite sauf accord pralable et crit de l'diteur, en dehors des cas prvus par la lgislation en vigueur en France. Il est prcis que son stockage dans une base de donnes est galement interdit.
Possibilities of the multichannel lidar spectrometer technique for investigation of the atmospheric aerosols and pollutions (2010)

In inelastic Raman scattering the scattered signal consists of radiation that has undergone a frequency shift which is characteristic for the stationary energy states of an irradiated molecule. Nowadays, Raman and fluorescence spectroscopy is commonly used in chemistry. Information on the radiation that results from transition between the vibrational energy states of the excited molecules, respectively, is specific to the chemical bonds and symmetry of molecules. This radiation therefore provides unique information regarding the irradiated molecule according to which the molecular species can be identified. Raman spectroscopy represents a particularly powerful tool for laser remote sensing because it allows us to both identify and quantify the trace constituent relative to the major constituents of a mixture. In this paper we present a multi-channel spectrometric lidar system which allows us to measure Raman and fluorescence spectrums that give us information on chemical signatures characteristic for chemical components of aerosol particles and pollutions. In the following, we describe the methodology, the system and we show experimental results.
Obinutuzumab for the treatment of lymphoproliferative disorders (2012)

Pre-clinical studies suggest that obinutuzumab is a more potent anti-CD20 mAb than Rituximab at inducing antibody-dependent cellular cytotoxicity (ADCC) and direct cell death (DCD). Obinutuzumab is safe and effective in CD20 + NHL and further study is warranted. Results of ongoing Phase III clinical trials comparing Obinutuzumab to Rituximab in different disease settings and with different chemotherapy regimens are eagerly awaited.
On the implementation of a short-time spectral analysis method for system identification (1980)

Recent work has demonstrated the utility of a short-time spectral analysis approach to the problems of spectral estimation and system identification. In this paper several important aspects of the implementation are discussed. Included is a discussion of the computational effects (e.g., storage, running time) of the various analysis parameters. A computer program is included which illustrates one implementation of the method.
Two synthesis of optically pure (IR,2R)-1,2-dimethylcyclopentane (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo synthesis of optically pure (IR,2R)-1,2-dimethylcyclopentaneW. C. M. C. Kokke and Frans A. VarkevisserCite this: J. Org. Chem. 1974, 39, 11, 1535–1539Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://pubs.acs.org/doi/10.1021/jo00924a018https://doi.org/10.1021/jo00924a018research-articleACS PublicationsRequest reuse permissionsArticle Views405Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-performance all-optical silicon microswitch (2004)

An integrated micron-size all-optical Si switch capable of 94.7 GHz operation frequency is presented. The device consists of a microring resonator formed by Si/SiO2 slot-waveguides with a low-index nonlinear optical material in the slot region. Strong optical confinement in the slot permits an achievement of low switching power of 6.2 mW.
Evaluation of a fiberoptic-based system for measurement of optical properties in highly attenuating turbid media (2006)

Improvements in system design have led to significant reductions in optical property estimation error. While the incorporation of a bifurcated illumination fiber shows promise for improving the accuracy of mu's estimates, further study of this approach is needed to elucidate the source of discrepancies between measurements and simulation results at low mu(a) values.
9 mm Cutoff 256x256 GaAs/AlxGa1-xAs Quantum Well Infrared Photodetector Focal Plane (1995)

In this paper, we discuss the development of very sensitive long wavelength infrared (LWIR).
Thermal and structural properties of fusion related materials (1995)

This study presents a compilation of the thermal and structural properties of materials usually considered in fusion experimental devices and research work related to near term experimental machines and future prototype power plants. The thermal and structural properties of fusion power plant materials are tabulated primarily as a function of temperature. The range of temperatures for the tabulated properties is from room temperature to the melting point. For materials in the liquid state properties start at the melting point and extend to the highest anticipated operational temperature. Material properties included in this study are: poison ratio, density, specific heat capacity, thermal conductivity, yield stress, usually at 0.2% strain, ultimate stress, usually tensile, elastic modulus, and coefficient of thermal expansion. The literature search clearly demonstrated that although knowledge of the properties of several materials is quite satisfactory for both unirradiated and irradiated, conditions, for the majority of material properties, especially under irradiation conditions, knowledge is very poor. (author).
A comparison of unit process systems for anchorage dependent cells. (1987)

The performance of three unit process systems for anchorage-dependent cells, namely the APV plate heat exchanger, glass bead reactor and microcarrier culture are reviewed. All three systems have been used for the production of various viruses and protein products and their use in a production process is related to various scaling-up parameters.