gebhart/patrepeval huggingface dataset:
The mouse osteopontin gene. Expression in monocytic lineages and complete nucleotide sequence. (1990)

Murine macrophage cell lines and resident macrophages showed various levels of expression of the murine osteopontin (OP) gene, and macrophage stimulating agents were found to enhance transcription of the gene with kinetics which are unique for each stimulator. The organization of the murine OP gene was determined. The gene comprises six exons and five introns and spans approximately 4.8 kilobases. Exon 1 contains the 16 amino acids of the leader sequence. Exons 2, 3, 4, 5, and 6 encode 12, 27, 14, 94, and 129 amino acid residues, respectively. Exon 5 encodes regions containing 10 consecutive Asp amino acid residues and a Gly-Arg-Gly-Asp-Ser peptide. Exon 6 encodes the C-terminal half of OP and contains no 15- and 54-base pair nucleotide sequences which are deleted in murine OP cDNA compared to that of rat OP cDNA. Since Southern blot analysis indicated that the OP gene is a single copy, it is obvious that the murine OP cDNA has the sequence previously determined (Miyazaki, Y., Setoguchi, M., Yoshida, S., Higuchi, Y., Akizuki, S., and Yamamoto, S. (1989) Nucleic Acids Res. 17, 3298). A comparison with the cDNA sequences reported previously suggested the presence of nucleotide sequence polymorphisms. The 5' end of the murine OP gene was defined by primer extension and S1 nuclease mapping. Sequence analysis of the 5'-flanking DNA revealed the presence of many potential regulatory motifs.
The internationalization of engineering education: a tale of two countries (2003)

Two international exchange programs in engineering between universities in Japan and Canada, are described in order to explain the significant benefits gained by the undergraduate and graduate students, as well as the academic staff who participate, and to highlight key principles generally followed in the design and execution of exchange programs. One notable and successful engineering exchange program is between the University of Waterloo, located in Southern Ontario, Canada, and Tottori University in Japan, while the other is between the University of Waterloo and Kyoto University in Japan. Both of these programs include foreign students taking courses for credit or audit at the host university, and, for the case of graduate students, also receiving guidance in their research. Moreover, upon completion of one academic semester in Japan, all of the undergraduate Waterloo students studying at Tottori University are employed in Japanese industry for three to four months before returning to Canada. Of paramount importance to the education of the participating undergraduate and graduate students is the opportunity to learn, by first-hand experience, the language and culture of a foreign country. In fact, one of the key findings of a survey completed by Canadian and Japanese students who took part in the exchange programs, is that living in a different culture greatly enhanced their own personal development. The addition of this international perspective to a solid education in engineering opens many doors of opportunity for exchange program alumni, who are well prepared to fully participate in the global marketplace of the 21st century, and to assist society in responsibly reaching an equitable and sustainable future.
Chromatographic resolution of chicken phosvitin. Multiple macromolecular species in a classic vitellogenin-derived phosphoprotein (1986)

Chicken phosvitin was prepared from egg yolk by a variety of published methods, including a modification of our own original procedure. Yolk granules and all phosvitin preparations have been previously found to contain major phosphoproteins at Mr 40,000 and 33,000 and minor satellite components when electrophoresed on polyacrylamide gradient gels and stained with Stains-all. However, only our current preparation contained three additional phosphoproteins (Mr 18,000, 15,000 and 13,000) that are also present in yolk granules. Our current phosvitin preparation also appeared to have additional components when compared with other preparations by size-exclusion and anion-exchange chromatography. Particularly complex but entirely reproducible patterns were obtained by hydrophobic-interaction chromatography. However, a cross-referencing of fractions eluted by size-exclusion chromatography to the other procedures employed, including gel electrophoresis, reinforced the notion that unfractionated chicken phosvitin contains at least five major components, designated B, C, E1, E2 and F for the Mr 40,000, 33,000, 15,000, 18,000, and 13,000 phosphoproteins, respectively. Stoichiometric considerations lead us to suggest that vitellogenin I gives rise to phosvitins C and F, vitellogenin II gives rise to phosvitin B, and vitellogenin III gives rise to either phosvitin E1 or E2, but not both. Thus, a fourth, as yet undetected, vitellogenin may exist for the chicken.
Robust and High Data Rate Wireless Link for Security Between a Bus and a Control Centre (2007)

For transport operators today, making passengers and crews feel safer on urban mass transportation systems, and curbing damage to rolling-stock, are two of the main priorities. To satisfy these needs, they rely more and more on surveillance systems based on audio and video sensors which are able to detect automatically potentially dangerous situations and to send an alarm signal, with the corresponding audio and video streams, to the security staff at the control centre. When the system is embedded in a public transport vehicle, the transmission system must be a wireless one and must be able to offer high data rate and high quality of service in order not to cause a deterioration to the audio and video stream. The work presented in this paper concerns the development of such a transmission system from an urban bus to a control centre. Existing telecommunication standards offering large radio coverage generally offer asymmetrical links and none of them is able to support very high data rate in up-link. The new IEEE802.16 or WiMAX (worldwide interoperability for microwave access) standard will offer 3 to 5 Mbps on both transmission directions. The paper will present a 2x4 MIMO transmission system based on the physical layer called PHY-OFDM of IEEE802.16-d with STBC code and turbo processing to increase robustness. Different signal processing solutions were evaluated in simulation with measured propagation channels with various correlation degrees (suburban and urban canyon) representative of urban bus environments. A real transmission system has been built on the basis of the simulation one. Experiments in real conditions were conducted in the centre of Lille in the north of France.
In Depth Analysis of Pressure-Sensitive Adhesive Patch-Assisted Delivery of Memantine and Donepezil Using Physiologically Based Pharmacokinetic Modeling and in Vitro/in Vivo Correlations (2018)

The objective of this work was to evaluate the feasibility of transdermal delivery of two widely prescribed dementia drugs for the Alzheimer's disease. In this regard, the drug in adhesive patches of memantine (ME) co-loaded with donepezil (DO) was prepared using an ethylene vinyl acetate polymer and characterized for drug content, the crystallinity of drugs in the polymer matrix, and in vitro permeation. To understand the different physical and chemical processes underlying the percutaneous absorption, it is required to employ a comprehensive model that accounts for the anatomy and physiology of the skin. A transdermal physiologically based pharmacokinetic (TPBPK) model was developed and was integrated in a compartmental pharmacokinetic model to predict the plasma drug concentrations in rats. The model predictions showed a good fit with the experimental data, as evaluated by the prediction error calculated for both drugs. It was evident from the simulations that the drug diffusivity and partition coefficient in the polymer matrix are the critical parameters that affect the drug release from the vehicle and subsequently influence the in vivo pharmacokinetic profile. Moreover, a correlation function was built between the in vitro permeation data and in vivo absorption for both ME and DO. A good point-to-point in vitro/in vivo correlation (IVIVC, Level A correlation) was achieved by predicting the plasma concentrations with convolution for the entire study duration. The results of our study suggested that the implementation of mechanistic modeling along with IVIVC can be a valuable tool to evaluate the relative effects of formulation variables on the bioavailability from transdermal delivery systems.
Supramolecular chemistry: molecular aggregates of closo-B10H102- with [12]mercuracarborand-4 (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSupramolecular chemistry: molecular aggregates of closo-B10H102- with [12]mercuracarborand-4Xiaoguang Yang, Carolyn B. Knobler, and M. Frederick HawthorneCite this: J. Am. Chem. Soc. 1993, 115, 11, 4904–4905Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/ja00064a067https://doi.org/10.1021/ja00064a067research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Single‐Dose Liposomal Amphotericin B in the Treatment of Visceral Leishmaniasis in India: A Multicenter Study (2003)

Widespread antimony resistance renders conventional amphotericin B the only option for the treatment of visceral leishmaniasis (VL) in North Bihar, India. Because of its excellent safety profile, a large dose (7.5 mg/kg) of liposomal amphotericin B (L-AmB) was given to each of 203 patients with VL at 4 treatment centers, and the patients were discharged the next day. At initial clinical and parasitological follow-up, performed on day 30 after treatment, evidence of a cure was seen in 195 (96%) of 203 patients (95% CI, 92-98); 4 patients experienced treatment failure. Two patients were lost to follow-up, 2 died (one due to progressive disease and another, 5 months after treatment, due to an unrelated illness), and 12 experienced relapses during follow-up. Thus, 183 patients (90%; 95% CI, 85-94) had obtained final cure 6 months after treatment. Very few adverse events (fever with rigor, in 9.8% of patients) were seen. Single-dose L-AmB (7.5 mg/kg) treatment is safe and effective, and it may be used for the mass treatment of VL in India.
<scp>S</scp> inn <scp>F</scp> éin (2009)

Sinn Féin, “We Ourselves” or “Ourselves Alone” in Gaelic, was created by Arthur Griffith in 1905, and began as a nationalist political party whose goal was to create an Irish republic free from British control. The party entered the centuries‐old conflict between the majority Irish Catholics of southern Ireland and the minority Protestant groups of northern Ireland at a time when the idea of home rule, or Irish self‐rule, was being hotly debated in Britain's parliament.
Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy (2010)

The combined approach of DNA pooling followed by MPR strongly facilitates mutation analysis in broadly heterogeneous single gene disorders. The lack of mutations in 75% of patients in this cohort indicates further extensive heterogeneity in NPHP-AC.
Micromechanical switches fabricated using nickel surface micromachining (1997)

Micromechanical switches have been fabricated in electroplated nickel using a four-level surface micromachining process. The simplest devices are configured with three terminals, a source, a drain, and a gate and are 30 /spl mu/m wide, 1 /spl mu/m thick, and 65 /spl mu/m long. A voltage applied between the gate and source closes the switch, connecting the source to the drain. Devices switch more than 10/sup 9/ cycles before failure and exhibit long-lifetime hot switching currents up to 5 mA. The initial contact resistance is less than 50 m/spl Omega/. The breakdown (stand-off) voltage between the source and the drain is greater than 100 V and the off-current is less than 20 fA at 100 V.
A comprehensive review of sodium layered oxides: powerful cathodes for Na-ion batteries (2014)

The room temperature Na-ion secondary battery has been under focus lately due to its feasibility to compete against the already well-established Li-ion secondary battery.
Prolonged Sleep Apnea and Respiratory Instability: A Discriminative Study (1977)

This report is based on a study of 53 infants, 28 of whom had clinically observed prolonged apnea (greater than or equal to 20 seconds) during sleep whereas the remaining did not. In addition to the clinical observations, each infant was studied in a sleep laboratory during a complete nap, and a continuous recording was made of respiratory activity and rapid eye movements. Measurements were made of all apneic pauses (greater than or equal to 2 seconds) observed in the laboratory and the two groups of infants were compared in terms of the frequency and average duration of apneic pauses, the longest apneic pause, the amount of periodic apnea, and the relative amount of apnea. The infants with prolonged sleep apnea had, during a single nap, more frequent and longer apneic pauses and more periodic apnea. This supports the hypothesis that respiratory instability during sleep and prolonged apnea have a common etiology. By employing a multiple linear regression model and including all laboratory apnea measures in a single analysis, a composite laboratory score was developed to differentiate members of the two groups. It would thus appear that the study of infants during a single nap could assist in the identification of infants at risk for prolonged sleep apnea and provide an indirect method for determining the influence of a number of variables on the occurrence of prolonged sleep apnea. Pediatrics, 59:962-970, 1977, SLEEP, APNEA, RESPIRATORY INSTABILITY.
Pavonin: A New Five-Membered Lactone from Adenanthera Pavonina Linn. (Mimoaceae) (2004)

A new five-membered lactone named pavonin with an exo-cyclic double bond has been isolated from the methanol soluble part of Adenanthera pavonina Linn. belonging to the family Mimoaceae. The structure of pavonin has been established with the aid of spectroscopic techniques including decoupling and HMBC experiments.
Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis (2011)

Molecular events leading to epithelial ovarian cancer are poorly understood but ovulatory hormones and a high number of life-time ovulations with concomitant proliferation, apoptosis, and inflammation, increases risk. We identified genes that are regulated during the estrous cycle in murine ovarian surface epithelium and analysed these profiles to identify genes dysregulated in human ovarian cancer, using publically available datasets. We identified 338 genes that are regulated in murine ovarian surface epithelium during the estrous cycle and dysregulated in ovarian cancer. Six of seven candidates selected for immunohistochemical validation were expressed in serous ovarian cancer, inclusion cysts, ovarian surface epithelium and in fallopian tube epithelium. Most were overexpressed in ovarian cancer compared with ovarian surface epithelium and/or inclusion cysts (EpCAM, EZH2, BIRC5) although BIRC5 and EZH2 were expressed as highly in fallopian tube epithelium as in ovarian cancer. We prioritised the 338 genes for those likely to be important for ovarian cancer development by in silico analyses of copy number aberration and mutation using publically available datasets and identified genes with established roles in ovarian cancer as well as novel genes for which we have evidence for involvement in ovarian cancer. Chromosome segregation emerged as an important process in which genes from our list of 338 were over-represented including two (BUB1, NCAPD2) for which there is evidence of amplification and mutation. NUAK2, upregulated in ovarian surface epithelium in proestrus and predicted to have a driver mutation in ovarian cancer, was examined in a larger cohort of serous ovarian cancer where patients with lower NUAK2 expression had shorter overall survival. In conclusion, defining genes that are activated in normal epithelium in the course of ovulation that are also dysregulated in cancer has identified a number of pathways and novel candidate genes that may contribute to the development of ovarian cancer.
Space-Division Multiplexed High-Speed Superchannel Transmission Over Few-Mode Fiber (2012)

Space-division multiplexed (SDM) transmission based on multi-core (MCF) or multi-mode fiber (MMF) emerges as one of the most promising solutions for overcoming the capacity limit of standard single mode fiber (SSMF). This paper places a focus on the MMF transmission for which a data rate of 100-Gb/s and beyond has been recently demonstrated through coherent-optical OFDM (CO-OFDM) and single-carrier (SC) superchannel transmission based on specially-designed few-mode fibers (FMF). However, to unleash the full potential of the high data rate SDM transmission requires brand-new research from device to system level. In this paper, we elucidate the overall system architecture, critical components and sub-system modules for SDM transmission and report the up-to-date demonstration of SDM superchannel transmission. We envisage that the combination of SDM and OFDM modulation could be a potential key route to the future Tb/s and beyond optical transports.
Levitronix CentriMag Third-Generation Magnetically Levitated Continuous Flow Pump as Bridge to Solution (2011)

The Levitronix CentriMag (Levitronix LLC, Waltham, MA) ventricular assist device (VAD) is a magnetically levitated rotary pump designed for temporary extracorporeal support. Between February 2004 and May 2010, 42 consecutive adult patients were supported with Levitronix at our institution (32 men; age 62.3 ± 10.5 years, range: 31-76 years). Indications for support were (group A, n = 37) failure to wean from the cardiopulmonary bypass in the setting of postcardiotomy (n = 23), primary donor graft failure (n = 4), or right ventricular failure after axial left VAD (LVAD) placement (n = 10) and (group B, n = 5) refractory heart failure after acute myocardial infarction. The mean support time was 11.2 ± 6.8 days (range: 3-43 days) in group A and 8.6 ± 4.3 days (range: 5-11 days) in group B. In the postcardiotomy cohort (group A), 11 (47.8%) patients were weaned from support as all were supported graft failure patients. Eight patients of axial LVAD cohort were weaned from right VAD (RVAD). One patient was bridged to heart transplantation (Htx). Thirteen (35.1%) patients died on support in group A. In group B, one patient was bridged to Htx and four died on support. In overall population, bleeding requiring reoperation occurred in 15 (35.7%) cases and cerebral major events in four (9.5%). There were no device failures. Of the 23 (54.7%) patients who recovered and were discharged home, 20 (47.6%) are presently alive, and additionally, two patients of both groups who were bridged to Htx (overall n = 22, 52.3%). The Levitronix proved to be useful in patients previously considered nonsuitable for transplantation or long-term assist device. The device was technically easy to manage, and the results were encouraging.
Effects of Immunization Against Bone Morphogenetic Protein 15 and Growth Differentiation Factor 9 on Ovulation Rate, Fertilization, and Pregnancy in Ewes1 (2004)

Immunization of ewes against growth differentiation factor 9 (GDF9) or bone morphogenetic protein 15 (BMP15) can lead to an increased ovulation rate; however, it is not known whether normal pregnancies occur following such treatments. The aims of the present study were to determine the effects of a short-term immunization regimen against BMP15 and GDF9 on ovulation rate, fertilization of released oocytes, the ability of fertilized oocytes to undergo normal fetal development, and the ability of immunized ewes to carry a pregnancy to term. Ewes were given a primary and booster immunization against keyhole limpet hemocyanin (KLH; control, n = 50), a GDF9-specific peptide conjugated to KLH (GDF9, n = 30), or a BMP15-specific peptide conjugated to KLH (BMP15, n = 30). The estrous cycles of all ewes were synchronized, and ewes were joined with fertile rams approximately 14 days after the booster immunization. The number of corpora lutea was determined by laparoscopy 3-4 days following mating. Subsequently, about one-half of the ewes in each group underwent an embryo transfer procedure 4-6 days following mating, with the embryos being transferred to synchronized, nonimmunized recipients. The remaining ewes were allowed to carry their pregnancies to term. Short-term immunization against either BMP15 or GDF9 peptides resulted in an increase in ovulation rate with no apparent detrimental affects on fertilization of released oocytes, the ability of fertilized oocytes to undergo normal fetal development, or the ability of the immunized ewes to carry a pregnancy to term. Therefore, regulation of BMP15, GDF9, or both is potentially a new technique to enhance fecundity in some mammals.
science insights (1997)

RETURN TO ISSUEPREVNewsNEXTscience insightsScience and law:RUDY BAUMCite this: Chem. Eng. News 1997, 75, 39, 38Publication Date (Print):September 29, 1997Publication History Published online12 November 2010Published inissue 29 September 1997https://pubs.acs.org/doi/10.1021/cen-v075n039.p038https://doi.org/10.1021/cen-v075n039.p038newsACS PublicationsCopyright © 1997 American Chemical SocietyArticle Views7Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Wind Get e-Alerts