gebhart/patrepeval huggingface dataset:
The Reaction of Dihaloanisoles with Sodium Amide in Liquid Ammonia (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reaction of Dihaloanisoles with Sodium Amide in Liquid AmmoniaRobert A. Benkeser and Gene SchrollCite this: J. Am. Chem. Soc. 1953, 75, 13, 3196–3197Publication Date (Print):July 1, 1953Publication History Published online1 May 2002Published inissue 1 July 1953https://doi.org/10.1021/ja01109a045RIGHTS & PERMISSIONSArticle Views245Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (256 KB) Get e-Alertsclose Get e-Alerts
Synthesis, structure, and properties of π-cyclo-octenyl-π-cyclo-octa-1,5-dienecobalt (1968)

Treatment of cobalt dichloride suspended in a mixture of cyclo-octa-1,5-diene, pyridine, and tetrahydrofuran with metal sodium affords a brown crystalline complex, Co(C8H13)(C8H12). Structural proof has been obtained which shows conclusively that the complex is π-cyclo-octenyl-π-cyclo-octa-1,5-dienecobalt. Thermally it is stable, and shows no tendency for valence tautomerism. Remarkable mobility of the hydrogen atoms of the ligand has been observed in some chemical reactions, and this is interpreted in terms of the molecular structure.
XII. <i>The function of osmotic pressure in the analogy between solutions and gases</i> (1888)

of the osmotic poressure (
A facile asymmetric synthesis of 1‐amino‐2,2,2‐trifluoroethanephosphonic acid (2000)

Starting from the fundamental building block, trifluoromethylated N-(−)-α-methylbenzylacetimidoyl chloride, an asymmetric synthesis of 1-amino-2,2,2-trifluoroethanephosphonic acid was conveniently achieved by a base-catalyzed [1,3]-proton shift reaction of the intermediate dialkyl 1-imino-2,2,2-trifluoroethanephosphonate. © 2000 John Wiley & Sons, Inc. Heteroatom Chem 11:536–540, 2000
Cluster Headache: Response to Chlorpromazine (1980)

SYNOPSIS Chlorpromazine (CPZ), in doses ranging from 75–700 mg per day, gave full headache relief in twelve of thirteen (93%) of patients with the cluster headache syndrome. For nine, withdrawal of CPZ within two to three weeks was tolerated without recurrence of symptoms. After a period of extended remission, four of these found CPZ equally effective treatment for subsequent attacks. Three others received sustained relief from headache over six to eight months on maintenance CPZ at 75 mg per day although the cluster was not terminated. The apparent effectiveness of CPZ in this limited series is greater than that of other medications currently employed in the treatment of cluster headaches.
Bias Level Reduction of Incoherent Holograms (1969)

The known techniques for making incoherent holograms succeed for an object containing a small number of points; however, they fail in practice for an object with a great many discrete points or for an object with a continuous intensity distribution. This results because the intensity pattern generated in incoherent holography in a superposition of random intensity patterns generated by the individual object points. Thus, the intensity pattern contains a large bias level which masks the relatively small spatial variations of the pattern in the recording film grain noise. This paper describes a technique for eliminating the bias. By introducing a narrow band time modulation of the light in one path of an interferometer used to generate the hologram intensity pattern, the spatially varying part of the hologram intensity pattern is modulated at the time frequency, while the bias part is unmodulated. The bias part can then be eliminated by performing a point-by-point time correlation over the hologram plane. Experimental results are presented.
Rhinosinusitis and Aspirin-Exacerbated Respiratory Disease (2012)

Rhinosinusitis is a feature of aspirin-exacerbated respiratory disease (AERD), which in the initial phase is manifested as nasal congestion, mostly affecting females at the age of around 30 years on average. Subsequently, nasal inflammation progresses to chronic eosinophilic rhinosinusitis, asthma, nasal polyposis, and intolerance to aspirin and to other NSAIDs. While it has been long established that NSAIDs cause inhibition of cyclooxygenase-1 (COX-1), leading to excessive metabolism of arachidonic acid (AA) to cysteinyl-leukotrienes (cys-LTs), there is now evidence that both cytokines and staphylococcus superantigens amplify the inflammatory process exacerbating the disease. This paper gives a brief overview of the development of chronic rhinosinusitis (CRS) in sensitive patients, and we share our experience in the diagnosis and management of CRS in AERD.
Bayesian Analysis for the Comparison of Nonlinear Regression Model Parameters: an Application to the Growth of Japanese Quail (2016)

This paper discusses the Bayesian approach as an alternative to the classical analysis of nonlinear models for growth curve data in Japanese quail. A Bayesian nonlinear modeling method is introduced and compared with the classical nonlinear least squares (NLS) method using three non-linear models that are widely used in modeling the growth data of poultry. The Gompertz, Richards and Logistic models were fitted to 499 Japanese quail weekly averaged body weight data. Normal prior was assumed for all growth curve parameters of the models with assuming Jeffreys' non-informative prior for residual variances. Models were compared based on the Bayesian measure of fit, deviance information criterion (DIC), and our results indicated the better fit of Gompertz and Richards models than the Logistic model to our data. Moreover, the parameter estimates of the models fitted by both approaches showed only small differences.
The safety and efficacy of MMF in lupus nephritis: a pilot study (2001)

Inducing and maintaining remission in patients with lupus nephritis may be difficult. Current treatments have significant toxicity. Mycophenolate mofetil (MMF) limits damage in murine models of lupus nephritis. We have assessed the efficacy and tolerability of MMF in the treatment of patients with long-standing or resistant lupus nephritis. We have treated 13 patients with biopsy proven lupus nephritis (two membranous nephropathy, four membranous nephropathy with superimposed proliferative changes, seven with proliferative glomerulonephritis). All patients had relapsed on conventional treatment or there were pressing indications to minimise steroid dosage or avoid alkylating agents. Nine out of 13 were treated with MMF and prednisolone, 3/10 with MMF alone and 1/10 with MMF, prednisolone and cyclosporine. Thirteen patients were treated with MMF for up to 37 months (median 25 months). Three patients were withdrawn from MMF during the first 8 months of treatment. The remainder tolerated MMF (median dose 1 g/day). Serological improvements were observed in 9/13 and steroid dosage was reduced in 8/10 patients. Infections occurred in 3/13. One patient relapsed. MMF significantly reduced the rate of decline of renal function. MMF should be considered in the treatment of long-standing or resistant lupus nephritis. Controlled clinical trials are required to confirm these findings.
Single-mode solid-state single photon source based on isolated quantum dots in pillar microcavities (2001)

We report the fabrication of a single-mode solid-state single photon source, based on an isolated InAs quantum dot (QD) on resonance with the fundamental mode of a pillar microcavity. Photon correlation experiments under pulsed excitation reveal a clear antibunching behavior. We show that a preparation of the single photons in a given quantum state (same spatial mode, same polarization) can be obtained by placing a QD in resonance with the nondegenerate fundamental mode of an elliptical micropillar.
Studies on heart. XXIV. Inhibitory effect of antiarrhythmic peptide (AAP) on experimental thromboses. (1984)

The antithrombotic action of antiarrhythmic peptide (AAP) was studied by using various in vivo thrombosis models. AAP (1, 10 or 100mg/kg, i.v., 10 mg/kg, i.p. or 100mg/kg, p.o.) significantly inhibited white thrombus formation on a silken thread in the extracorporeal shunt models in rats, its ED50 being about 30mg/kg, i.v. AAP (10mg/kg, i.v.) was effective in protecting rats against the decrease in platelet count, incidence of electrocardiographic alterations (T wave inversion and ST segment depression) typical of myocardial ischemia, and development of ectopic beats in the coronary thromboembolism induced by intravenous infusion of adenosine 5'-diphosphate. The peptide (10mg/kg, i.p.) was also effective in preventing thrombus formation in the lung and the decrease of platelet count induced by lactic acidosis in rats, and it (10mg/kg, i.v.) clearly inhibited thromboembolic death induced by rapid intravenous injection of collagen in mice. Daily treatments with the peptide (10mg/kg/d, i.p.) resulted in significant delay of the progression of gangrene and mummification in laurate-induced peripheral arterial occlusive disease in rats. AAP did not affect venous thrombus formation, blood flow through the carotid artery, plasma recalcification time or fibrinolytic activity in rats. It is likely that the potent antithrombotic action of AAP is mainly due to its anti-platelet-aggregating action in vivo. Ticlopidine (100mg/kg, p.o.) also showed a comparatively wide antithrombotic spectrum, like AAP, in the present thrombosis models, but ticlopidine lacked the action against myocardial ischemia, like aspirin (50mg/kg, s.c.).
II General Description of the Toronto Family Diagnosis Research Project, and Research Framework (1967)

II General Description of the Toronto Family Diagnosis Research Project, and Research Framework was published in Patterns of Social Functioning in Families with Marital and Parent-Child Problems on page 20.
High-throughput approach for detection of DNA bending and flexibility based on cyclization (2003)

We have developed a high-throughput approach to the labor-intensive problems of DNA cyclization, which we use to characterize DNA curvature and mechanical properties. The method includes a combinatorial approach to make the DNA constructs needed and automated real-time measurement of the kinetics using fluorescence. We validated the approach and investigated the flexibility of two kinds of nicked DNA and AT dinucleotide repeats. We found that, although the nicks hardly alter the bending flexibility, they significantly increase the torsional flexibility, and that the AT repeat has 28% (+/-12%) lower bending rigidity than a generic DNA sequence.
PSD3 downregulation confers protection against fatty liver disease (2022)

Abstract Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has a genetic component but, despite the common variants already identified, there is still a missing heritability component. Using a candidate gene approach, we identify a locus (rs71519934) at the Pleckstrin and Sec7 domain-containing 3 ( PSD3 ) gene resulting in a leucine to threonine substitution at position 186 of the protein (L186T) that reduces susceptibility to the entire spectrum of FLD in individuals at risk. PSD3 downregulation by short interfering RNA reduces intracellular lipid content in primary human hepatocytes cultured in two and three dimensions, and in human and rodent hepatoma cells. Consistent with this, Psd3 downregulation by antisense oligonucleotides in vivo protects against FLD in mice fed a non-alcoholic steatohepatitis-inducing diet. Thus, translating these results to humans, PSD3 downregulation might be a future therapeutic option for treating FLD.
Dependence of (Photo)electrochemical Properties on Geometry Factors of Hydrothermally Synthesized Delafossite Copper Gallium Oxide CuGaO<sub>2</sub>toward Oxygen Evolution Reaction (2018)

The recent surge of alternative clean energy with minimal environmental impact in a cost-effective way has attracted great interest in the exploration of new materials and/or structures as efficient electrodes for industry-level (photo)electrochemical water splitting. Delafossites with a general formula of ABO2 as a type of earth-abundant materials are expected to serve as ideal alternatives for water electrolysis. In this work, by fine-tuning the synthesis procedure of delafossite CuGaO2 via surfactant assisted hydrothermal route, we investigated the dependence of their (photo)electrochemical properties on geometry factors. More specifically, the synthesized CuGaO2 samples were characterized by powder XRD, SEM, EDX, XPS, FT-IR, UV-Vis, and BET surface area measurements. Moreover, their electrocatalytic and photoelectrocatalytic performance were tested and compared toward oxygen evolution reaction (OER). Based on cyclic voltammetry and electrochemical impedance spectroscopy, their onset potential, current density, Tafel slope, charge transfer resistance, and stability were investigated. It was found that the synthesized delafossite CuGaO2 nanoflakes with the smallest dimensions exhibited the best (photo)electrocatalytic performance and could serve as a potential candidate for cost-effective and active electrode material.
Asymmetric Hydrolysis of Racemic 2-Oxazolidinone Esters with Lipases (1984)

Journal Article Asymmetric Hydrolysis of Racemic 2-Oxazolidinone Esters with Lipases Get access Shigeki Hamaguchi, Shigeki Hamaguchi Biochemical Research Laboratories, Kanegafuchi Chemical Industry Co., Ltd., Takasago, Hyogo 676, Japan Search for other works by this author on: Oxford Academic Google Scholar Masanori Asada, Masanori Asada Biochemical Research Laboratories, Kanegafuchi Chemical Industry Co., Ltd., Takasago, Hyogo 676, Japan Search for other works by this author on: Oxford Academic Google Scholar Junzo Hasegawa, Junzo Hasegawa Biochemical Research Laboratories, Kanegafuchi Chemical Industry Co., Ltd., Takasago, Hyogo 676, Japan Search for other works by this author on: Oxford Academic Google Scholar Kiyoshi Watanabe Kiyoshi Watanabe Biochemical Research Laboratories, Kanegafuchi Chemical Industry Co., Ltd., Takasago, Hyogo 676, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 48, Issue 9, 1 September 1984, Pages 2331–2337, https://doi.org/10.1080/00021369.1984.10866481 Published: 01 September 1984 Article history Received: 15 March 1984 Published: 01 September 1984
ChemInform Abstract: Some Properties of Polyfluoroacyl and Polyfluoroacetonyl Fluorosulfates. (1988)

Abstract The anhydrides (I) decompose during the reaction with KF or SbF 5 to give the fluoroacyl fluorides (II).
Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer (2014)

The Immunoscore could be a useful prognostic marker in patients with rectal cancer treated by primary surgery. The determination of the immune infiltrate in biopsies before treatment could be a valuable information for the prediction of response to pCRT.
A high performance custom hardware backend search engine for a speech recognition system (2007)

Today's best quality speech recognition systems are implemented in software and demand high end processors just to achieve real-time decoding speeds; for many commercial applications, the requirements are too expensive and performance too limiting. Looking to the future, we do not see the problems getting much better with just software optimizations and general purpose processor advancements. Much like the evolution of the graphics chips, we believe speech recognition can significantly benefit moving from software to custom hardware; speech recognizers would yield higher performance, require less hardware resources, and dissipate less power without any sacrifice to word accuracy when compared against software running on a processor.
As part of Carnegie Mellon's In Silico Vox project which seeks to use efficient hardware to help alleviate problems plaguing speech recognition, our work in this thesis demonstrates how custom hardware can (1) be used to design a complete state-of-the-art speech recognition system and (2) significantly accelerate how fast recognition systems can decode speech while still maintaining a high accuracy. Referencing a respected open source software speech recognition system, CMU SPHINX 3.0, our custom hardware design can handle large vocabulary, continuous, speaker independent speech.
For our first objective, we implement a fully custom hardware speech recognizer using a 1000 word vocabulary task, which to our knowledge is the most complex speech recognizer ever to be placed in hardware only form. For our second objective, we design and implement a fast backend search engine, the most timing critical stage of speech recognition, using a 5000 word vocabulary task as an example. The design is able to achieve on average 10 times faster than real-time or 0.1 times real-time, running at 100 MHz, which, when pipelined with the other stages of decoding, is ∼6 to 17 times faster than software recognizers with similar accuracy.
Skateboarding e superfici urbane (2002)

The mammalian prion protein (PrPc) is a cellular protein of unknown function, an altered isoform of which (PrPsc) is a component of the infectious particle (prion) thought to be responsible for spongiform encephalopathies in humans and animals. The evolutionary conservation of the PrP gene has been reported in the genomes of many vertebrates as well as certain invertebrates. In the genome of nematode Caenorhabditis elegans, the sequence capable of hybridizing with the mammalian PrP cDNA probe has been demonstrated, predicting the presence of the PrP gene homologue in C.elegans. In this study, Southern analysis with the hamster PrP cDNA (HaPrP) probe confirmed the previous observation. Moreover, Northern analysis revealed that the sequence is actively transcribed in adult worms. Thus, we screened C.elegans cDNA libraries with the HaPrP probe and isolated a cDNA that hybridizes to the same sequence in C.elegans that hybridized with the HaPrP probe in the Southern and Northern analyses. The deduced amino acid sequence of this cDNA, however, is substantially homologous with heterogeneous nuclear ribonucleoprotein (hnRNP) core proteins rather than mammalian PrPc. The hnRNPs contain the glycine-rich domain in the C-terminal half of the molecule, which also seemed to be in PrPc at the N-terminal half of the molecule. Both of the glycine-rich domains are composed of tracts with high G + C content, indicating that these tracts may due to the hybridizing signals. These results suggest that this cDNA clone is derived from a novel hnRNP gene homologue in C.elegans but not from a predicted PrP gene homologue.
β-Aletheine<sup>1</sup> and Pantetheine<sup>2</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTβ-Aletheine1 and Pantetheine2Tsoo E. King, Charles J. Stewart, and Vernon H. CheldelinCite this: J. Am. Chem. Soc. 1953, 75, 6, 1290–1292Publication Date (Print):March 1, 1953Publication History Published online1 May 2002Published inissue 1 March 1953https://pubs.acs.org/doi/10.1021/ja01102a007https://doi.org/10.1021/ja01102a007research-articleACS PublicationsRequest reuse permissionsArticle Views100Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Silicon carbide split-gate MOSFET with merged Schottky barrier diode and reduced switching loss (2016)

A silicon carbide split-gate MOSFET (SG-MOSFET) is proposed in this paper, which features a Schottky barrier diode embedded above the JFET region between the split gates. Therefore, the proposed SG-MOSFET boasts a unipolar reverse conduction path with low turn-on voltage. Additionally, the gate-to-drain charge in the proposed device is greatly reduced, owing to the presence of the Schottky anode that is shorted to the source contact. The influence of key device parameters has been studied via device simulation using Sentaurus TCAD. Comprehensive comparisons between the proposed SG-MOSFET and the conventional MOSFET are made. Apart from the superior reverse conduction characteristics, the SG-MOSFET exhibits a significant lower switching loss thanks to both the low gate-to-drain charge and the elimination of charging/discharging currents for external freewheeling diodes.
Adjustable Cerebrospinal Fluid Shunt Valves in 3.0-Tesla MRI: a Phantom Study using Explanted Devices (2009)

Until suggestions can be made concerning the exposure of hydrocephalic patients to 3.0 T-MRI, further testing is necessary.
Spectroscopic and Microscopic Characterization and Behavior of an Optical pH Meter Based on a Functional Hybrid Monolayer Molecular System:  Porphyrin Molecules Covalently Assembled on a Molecularly Engineered Silica Surface (2006)

A covalently assembled monolayer of 5,10,15-tri{p-[9-methoxy-tri(ethyleneoxy)]phenyl}20(p-hydroxyphenyl)porphyrin molecules on a silica substrate was fabricated and characterized by X-ray photoelectron spectra, AFM images, and UV−vis measurements. In addition, its [H3O+] optical sensing behavior was studied and compared to that of the parent water-soluble star polymer 5,10,15,20-tetrakis{p-[ω-methoxy-poly(ethyleneoxy)]phenyl}porphyrin having ∼40 repetitive units in each of the poly(oxyethylene) branches. Upon immersion in increasingly acidic solutions, the UV−vis absorbance spectra of the porphyrin-assembled monolayer show the gradual disappearance of the Soret band at 427.2 nm and the progressive increase of a new band at 459.1 nm. In strongly acidic solutions (pH 1.0), the spectrum is substantially dominated by the new band and remains unchanged even with more acidic solutions. The simple washing with water and drying under a N2 gas stream totally recovers the starting Soret signal. The presence of Mn(II), Co(II), Ni(II), Cd(II), or Pb(II) ions in water solution does not interfere with the behavior of the present optical acid pH meter. In contrast, the presence of Hg(II), Cu(II), or Zn(II) ions changes the pH-metering performance due to formation of metal−porphyrin complexes as revealed by UV−vis and MALDI-TOF measurements of metal-containing solutions of the similar 5,10,15,20-tetrakis{p-[ω-methoxy-poly(ethyleneoxy)]phenyl}porphyrin with ∼17 repetitive units in each poly(oxyethylene) branch.