gebhart/patrepeval huggingface dataset:
Information technology acceptance in a sample of government employees: a test of the technology acceptance model (2000)

The Technology Acceptance Model (TAM) [37] model, a derivative of the Theory of Reasoned Action (TRA) [26], attempts to explain the psychological determinants of attitudes, and subsequent acceptance behaviour, towards Information Technology (IT) in the workplace. The present study examined the efficacy of this psychologically based TAM within two samples of government workers experienced in the use of computers (N=108). All participants completed a self-report questionnaire consisting of both previously developed and purpose derived scales. The study achieved its purpose of replicating and validating a development of the TAM, although only moderate support for the model was found. The applied implications of the research and wider theoretical implications of the study are discussed.
Intra-Cavity Spectroscopy Using Amplified Spontaneous Emission in Fiber Lasers (2011)

Fiber laser sources offer interesting possibilities for gas sensors since they can operate over an extended wavelength range, encompassing the near-IR absorption lines of a number of important gases but a major problem is that overtone absorption lines of gases in the near-IR are relatively weak. In order to enhance sensitivity, we present here a simple method of intra-cavity absorption spectroscopy (ICAS) which makes use of the amplified spontaneous emission (ASE) already present within a fiber laser cavity. The ASE also provides a convenient broadband source for the simultaneous interrogation of several gases within the gain-bandwidth of the fiber laser. The key principle is based on adjusting the cavity attenuation to select an appropriate inversion level where the fiber gain curve is flat. Under this condition, the ASE undergoes multiple circulations within the fiber laser cavity, enhancing the effective path-length of a gas cell placed within the laser cavity. A theoretical model of system operation is given and we have experimentally demonstrated the principle of operation with acetylene and carbon dioxide using a simple erbium fiber laser system containing a 6 cm path-length, fiber coupled, intra-cavity, micro-optic gas cell. We have experimentally simultaneously observed 16 absorption lines for 1% acetylene gas in the 1530 nm region and detected the very weak carbon dioxide lines in this same wavelength region. A path length enhancement of in the linear regime has been demonstrated transforming the 6 cm micro-optic cell into an effective path length of m. We also demonstrate how the enhancement factor may be calibrated by use of a simple fiber-optic interferometer. Apart from the OSA, all components are inexpensive and the system is very simple to construct and operate.
6,8-DIIODOBENZOYLENEUREA, AND THE INTERACTION OF 5,7-DIHALOGENOISATOIC ANHYDRIDES WITH AMMONIA AND WITH ETHYLAMINE. 3-ETHYL-6,8-DIHALOGENOBENZOYLENEUREAS (1947)

ADVERTISEMENT RETURN TO ISSUEArticleNEXT6,8-DIIODOBENZOYLENEUREA, AND THE INTERACTION OF 5,7-DIHALOGENOISATOIC ANHYDRIDES WITH AMMONIA AND WITH ETHYLAMINE. 3-ETHYL-6,8-DIHALOGENOBENZOYLENEUREASFRED E. SHEIBLEYCite this: J. Org. Chem. 1947, 12, 6, 743–751Publication Date (Print):November 1, 1947Publication History Published online1 May 2002Published inissue 1 November 1947https://pubs.acs.org/doi/10.1021/jo01170a001https://doi.org/10.1021/jo01170a001research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A pattern matching co-processor for network security (2005)

It has been estimated that computer network worms and virus caused the loss of over $55B in 2003. Network security system use techniques such as deep packet inspection to detect the harmful packets. While software intrusion detection system running on general purpose processors can be updated in response to new attacks. They lack the processing power to monitor gigabit networks. We present a high performance pattern matching co-processor architecture that can be used to monitor and identify a large number of intrusion signature. The design consists of a bank of pattern matchers that are used to implement a highly concurrent filter. The pattern matchers can be programmed to match multiple patterns of various lengths, and are able to leverage the existing databases of threat signatures. We have been able to program the filters to match all the payload patterns defined in the widely used Snort network intrusion detection system at a rate above 7 Gbps, with memory space left to accommodate threat signatures that become available in the future.
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells (2014)

This study is among the first to report the VM formation in cultured human pancreatic cancer cells. And we provided strong evidence to suggest that SAHA executes significant anti-VM efficiency in the progressive pancreatic cancer cells. Thus, SAHA could be further investigated as a promising anti-pancreatic cancer agent.
Vaccination with recombinant NetB toxin partially protects broiler chickens from necrotic enteritis (2013)

NetB toxin from Clostridium perfringens is a major virulence factor in necrotic enteritis in poultry. In this study the efficacy of NetB as a vaccine antigen to protect chickens from necrotic enteritis was examined. Broiler chickens were immunized subcutaneously with purified recombinant NetB (rNetB), formalin treated bacterin and cell free toxoid with or without rNetB supplementation. Intestinal lesion scores and NetB antibody levels were measured to determine protection after mild oral gavage, moderate in-feed and heavy in-feed challenges with virulent C. perfringens isolates. Birds immunized with rNetB were significantly protected against necrotic enteritis when challenged with a mild oral dose of virulent bacteria, but were not protected when a more robust challenge was used. Bacterin and cell free toxoid without rNetB supplementation did not protect birds from moderate and severe in-feed challenge. Only birds immunized with bacterin and cell free toxoid supplemented with rNetB showed significant protection against moderate and severe in-feed challenge, with the later giving the greatest protection. Higher NetB antibody titres were observed in birds immunized with rNetB compared to those vaccinated with bacterin or toxoid, suggesting that the in vitro levels of NetB produced by virulent C. perfringens isolates are too low to induce the development of a strong immune response. These results suggest that vaccination with NetB alone may not be sufficient to protect birds from necrotic enteritis in the field, but that in combination with other cellular or cell-free antigens it can significantly protect chickens from disease.
Polyphase Code Design for Orthogonal Netted Radar Systems (2004)

Orthogonal netted radar systems (ONRS) can fundamentally improve radar performance by using a group of specially designed orthogonal signals. A novel hybrid algorithm is proposed to numerically optimize such orthogonal polyphase code sets. The proposed algorithm integrates a statistical simulated annealing algorithm with the traditional iterative code selection method and is demonstrated to be effective for the design of polyphase signals used in ONRS. Some of the design results are presented and discussed. The effect of Doppler frequency shift on the performance of the designed signals is also investigated.
A Mechanism for the Hydrolysis of Cyanamide in Acid Solution (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Mechanism for the Hydrolysis of Cyanamide in Acid SolutionMary L. KilpatrickCite this: J. Am. Chem. Soc. 1947, 69, 1, 40–46Publication Date (Print):January 1, 1947Publication History Published online1 May 2002Published inissue 1 January 1947https://pubs.acs.org/doi/10.1021/ja01193a010https://doi.org/10.1021/ja01193a010research-articleACS PublicationsRequest reuse permissionsArticle Views718Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Organometallic compounds of the lanthanides. 42. Bis(dimethoxyethane)lithium bis(cyclopentadienyl)bis(trimethylsilyl)lanthanide complexes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganometallic compounds of the lanthanides. 42. Bis(dimethoxyethane)lithium bis(cyclopentadienyl)bis(trimethylsilyl)lanthanide complexesHerbert Schumann, Siegbert Nickel, Joerg Loebel, and Joachim PickardtCite this: Organometallics 1988, 7, 9, 2004–2009Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://doi.org/10.1021/om00099a016RIGHTS & PERMISSIONSArticle Views447Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (777 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin (2006)

Given their accessibility, multipotent skin-derived cells might be useful for future cell replacement therapies. We describe the isolation of multipotent stem cell-like cells from the adult trunk skin of mice and humans that express the neural crest stem cell markers p75 and Sox10 and display extensive self-renewal capacity in sphere cultures. To determine the origin of these cells, we genetically mapped the fate of neural crest cells in face and trunk skin of mouse. In whisker follicles of the face, many mesenchymal structures are neural crest derived and appear to contain cells with sphere-forming potential. In the trunk skin, however, sphere-forming neural crest-derived cells are restricted to the glial and melanocyte lineages. Thus, self-renewing cells in the adult skin can be obtained from several neural crest derivatives, and these are of distinct nature in face and trunk skin. These findings are relevant for the design of therapeutic strategies because the potential of stem and progenitor cells in vivo likely depends on their nature and origin.
Physiological and Transcriptional Response of<i>Lactobacillus casei</i>ATCC 334 to Acid Stress (2010)

This study investigated features of the acid tolerance response (ATR) in Lactobacillus casei ATCC 334. To optimize ATR induction, cells were acid adapted for 10 or 20 min at different pH values (range, 3.0 to 5.0) and then acid challenged at pH 2.0. Adaptation over a broad range of pHs improved acid tolerance, but the highest survival was noted in cells acid adapted for 10 or 20 min at pH 4.5. Analysis of cytoplasmic membrane fatty acids (CMFAs) in acid-adapted cells showed that they had significantly (P < 0.05) higher total percentages of saturated and cyclopropane fatty acids than did control cells. Specifically, large increases in the percentages of C(14:0), C(16:1n(9)), C(16:0), and C(19:0(11c)) were noted in the CMFAs of acid-adapted and acid-adapted, acid-challenged cells, while C(18:1n(9)) and C(18:1n(11)) showed the greatest decrease. Comparison of the transcriptome from control cells (grown at pH 6.0) against that from cells acid adapted for 20 min at pH 4.5 indicated that acid adaption invoked a stringent-type response that was accompanied by other functions which likely helped these cells resist acid damage, including malolactic fermentation and intracellular accumulation of His. Validation of microarray data was provided by experiments that showed that L. casei survival at pH 2.5 was improved at least 100-fold by chemical induction of the stringent response or by the addition of 30 mM malate or 30 mM histidine to the acid challenge medium. To our knowledge, this is the first report that intracellular histidine accumulation may be involved in bacterial acid resistance.
Monte Carlo simulation of the enzymatic lysis of yeast (1997)

The overall reaction in the enzymatic lysis of yeast takes place in three major steps: (i) the two-layer wall is digested, (ii) the cell bursts under the osmotic pressure difference to release its intracellular material, and (iii) the intracellular material is digested by the enzymes still present in the solution. The first and third steps are continuous processes, adequately described by Michaelis-Menten kinetic models. The second step is a discrete event, statistical in nature. A model of engineering value should effectively bridge the gap between the two continuous processes (first and third steps). In this work, Monte Carlo simulations are used to identify a suitable function that captures the statistical nature of cell rupture and represents the rate of release of intracellular material. It is shown that the two-parameter beta distribution function serves this purpose most effectively. Comparisons with experimental results indicate that the cell rupture ratio is a widely distributed statistical function.
Deposition of cubic SiC films on silicon using dimethylisopropylsilane (1995)

We have grown cubic SiC films on the Si(100) and Si(111) substrates in the temperature range of 750–970 °C by low pressure organometallic chemical vapor deposition (LP-OMCVD) using dimethylisopropylsilane (CH3)2CHSiH(CH3)2 as a single molecular precursor. On a carbonized Si(100) substrate, a polycrystalline cubic SiC film was obtained at 960 °C. Cubic-type SiC films were also grown on uncarbonized Si(100) surfaces at 850 °C. At lower temperatures, amorphous SiC films were formed. These growth temperatures are much lower than those reported previously by others. On an uncarbonized Si(111) substrate, however, strongly oriented growth of cubic SiC film in the [111] direction was observed at the growth temperature of 970 °C.
Effects of Probiotic Supplementation on Short Chain Fatty Acids in the <i>App</i><sup><i>NL</i>-<i>G</i>-<i>F</i></sup> Mouse Model of Alzheimer’s Disease (2020)

These data demonstrate intestinal dysbiosis in the AppNL-G-Fmouse model of AD. Probiotic VSL#3 feeding altered both serum and brain levels of lactate and acetate in AppNL-G-Fmice correlating with increased expression of the neuronal activity marker, c-Fos.
Photocatalysis in Gold Nanocage Nanoreactors (2009)

The photodegradation of methyl orange was found to take place very efficiently using hollow Au nanocages which are known to have remaining Ag on their interior walls which can be oxidized to Ag(2)O. The degradation rate is found to be more efficient than photodegradation reaction using semiconductor nanomaterials, such as TiO(2) and ZnO. The reaction rate is found to increase by increasing the degree of Ag oxidation on the interior wall of the nanocages prior to the reaction and is a function of the nanocavity size and the pore density of the nanocage walls. As the cage size varies, it is found that the photocatalytic rate increases and then decreases with a maximum rate at nanoparticle size of 75 nm with a medium pore density in the walls. All these results suggest that the catalysis is occurring inside the cavity, whose interior walls are covered with the Ag(2)O catalysts. Similar to the mechanism proposed in the degradation by the other semiconductors, we propose that the photodegradation mechanism involves the formation of the hydroxyl radical resulting from the photoexcitation of the Ag(2)O semiconductor. The observed results on the rate are discussion in terms of (1) the surface area of the inner wall covered with Ag (Ag(2)O), (2) the density and size of the pores in the walls, and (3) the cavity size of the nanoparticles.
Niphatenones, Glycerol Ethers from the Sponge <i>Niphates digitalis</i> Block Androgen Receptor Transcriptional Activity in Prostate Cancer Cells: Structure Elucidation, Synthesis, and Biological Activity (2011)

Extracts of the marine sponge Niphates digitalis collected in Dominica showed strong activity in a cell-based assay designed to detect antagonists of the androgen receptor (AR) that could act as lead compounds for the development of a new class of drugs to treat castration recurrent prostate cancer (CRPC). Assay-guided fractionation showed that niphatenones A (3) and B (4), two new glycerol ether lipids, were the active components of the extracts. The structures of 3 and 4 were elucidated by analysis of NMR and MS data and confimed via total synthesis. Biological evaluation of synthetic analogues of the niphatenones has shown that the enantiomers 7 and 8 are more potent than the natural products in the screening assay and defined preliminary SAR for the new AR antagonist pharmacophore, including the finding that the Michael acceptor enone functionality is not required for activity. Niphatenone B (4) and its enantiomer 8 blocked androgen-induced proliferation of LNCaP prostate cancer cells but had no effect on the proliferation of PC3 prostate cancer cells that do not express functional AR, consistent with activity as AR antagonists. Use of the propargyl ether 44 and Click chemistry showed that niphatenone B binds covalently to the activation function-1 (AF1) region of the AR N-terminus domain (NTD).
Investigating a Generic Paraphrase-Based Approach for Relation Extraction (2006)

Unsupervised paraphrase acquisition has been an active research field in recent years, but its effective coverage and performance have rarely been evaluated. We propose a generic paraphrase-based approach for Relation Extraction (RE), aiming at a dual goal: obtaining an applicative evaluation scheme for paraphrase acquisition and obtaining a generic and largely unsupervised configuration for RE. We analyze the potential of our approach and evaluate an implemented prototype of it using an RE dataset. Our findings reveal a high potential for unsupervised paraphrase acquisition. We also identify the need for novel robust models for matching paraphrases in texts, which should address syntactic complexity and variability.
NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection (2010)

Induced expression of neuroprotective genes is essential for maintaining neuronal integrity after stressful insults to the brain. Here we show that NR4A nuclear orphan receptors are induced after excitotoxic and oxidative stress in neurons, up-regulate neuroprotective genes, and increase neuronal survival. Moreover, we show that NR4A proteins are induced by cAMP response element binding protein (CREB) in neurons exposed to stressful insults and that they function as mediators of CREB-induced neuronal survival. Animals with null mutations in three of six NR4A alleles show increased oxidative damage, blunted induction of neuroprotective genes, and increased vulnerability in the hippocampus after treatment with kainic acid. We also demonstrate that NR4A and the transcriptional coactivator PGC-1alpha independently regulate distinct CREB-dependent neuroprotective gene programs. These data identify NR4A nuclear orphan receptors as essential mediators of neuroprotection after exposure to neuropathological stress.
Efficient AlGaAs channeled-substrate-planar distributed feedback laser (1988)

A wavelength-locked, AlGaAs channeled-substrate-planar distributed feedback laser has been made that operates to 40 mW pulsed. The Bragg grating is situated at the shoulders of the layers of AlGaAs and GaAs. Overall power efficiencies of 15% have been measured at 40 mW of output power.
Estrogen sulfotransferase of the rat liver: complementary DNA cloning and age- and sex-specific regulation of messenger RNA. (1992)

Mammalian estrogen sulfotransferase (EST; EC 2.8.2.4) sulfurylates the hydroxyl group of estrogenic steroids by transferring the sulfate from a cosubstrate adenosine 3'-phosphate-5'-phosphosulfate. Sulfurylated steroids do not bind to the estrogen receptor with high affinity and, therefore, are hormonally inactive. We have purified rat liver EST and developed monoclonal antibody to this enzyme. By immunoscreening a lambda gt-11 expression library constructed from male rat liver cDNAs, the cDNA clone corresponding to EST was identified and isolated. A recombinant expression plasmid (pCMV5) containing this cDNA insert when transfected into COS-7 cells generated both immunologically and enzymatically active EST. With the help of this cDNA probe, we have explored the regulation of the EST mRNA in the liver and the possible role of this enzyme in sex hormone action. During the lifespan of male rats, only the young adult animals show hepatic androgen responsiveness. Also, estrogenic hormones strongly antagonize androgen action in the rat liver. Northern blot analysis of liver RNA derived from male rats of different ages shows that the androgen sensitivity of young adult animals is associated with a high expression of EST mRNA. During the same period, mRNA corresponding to dehydroepiandrosterone sulfotransferase is markedly (approximately 10-fold) down-regulated. Such a correlation is in concordance with the role of these enzymes in the maintenance of hepatic androgen sensitivity during young adult life by inactivating the estrogenic and sparing the androgenic steroids. Furthermore, the increase in the hepatic androgen sensitivity of androgen-treated female rats is also associated with the induction of EST.(ABSTRACT TRUNCATED AT 250 WORDS)