gebhart/patrepeval huggingface dataset:
Efficient Bug Triaging Using Text Mining (2013)

Large open source software projects receive abundant rates of submitted bug reports. Triaging these incoming reports manually is error-prone and time consuming. The goal of bug triaging is to assign potentially experienced developers to new-coming bug reports. To reduce time and cost of bug triaging, we present an automatic approach to predict a developer with relevant experience to solve the new coming report. In this paper, we investigate the use of five term selection methods on the accuracy of bug assignment. In addition, we re-balance the load between developers based on their experience. We conduct experiments on four real datasets. The experimental results show that by selecting a small number of discriminating terms, the F-score can be significantly improved.
Determination of Volumetric Sweep Efficiency in Barrancas Unit, Barrancas Field (2001)

Abstract This paper describes the analysis of the evaluation and surveillance of the waterflooding in the South of the Barrancas Field, after more than 30 years of water injection. The volumetric sweep efficiency is a parameter of complex evaluation in a mature field, and it has importance in the determination of the amount and spatial distribution of the additional oil recovery. The volumetric sweep efficiency can be calculated and predicted by means of two complementary methods that use basic principles of material balance, oil displacement by water and conformance plots. This procedure may help to evaluate the water injection efficiency with the current operation. Therefore the displacement efficiency and the remaining average oil saturation can be predicted. The evaluation techniques of volumetric sweep efficiency and water injection efficiency are tools that can be used with conventional decline curve analysis, to estimate and predict the unswept fraction of the reservoir by water injection and the additional oil recovery potential. This method needs production and injection data, and can be applied to any configuration of patterns. Finally, this lead to take the correct actions in the management of the waterflood and estimate whether the success of the performance of the waterflooding depends on volumetric efficiency or displacement efficiency.
The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes. (1994)

The clonal expansion of antigen-stimulated T-lymphocytes during an immune response is mediated by several lymphokines. Strong evidence now exists that the neuroendocrine hormone PRL is necessary, but not sufficient, for T-cell proliferation. Little is known, however, of the signal transduction mechanisms of the PRL receptor (PRLR) within T-cells. We demonstrate here that PRL stimulation of the T-cell line Nb2 induced the concentration- and time-dependent activation of the protein tyrosine kinase p59fyn, but not of four other src family protein tyrosine kinases. Activation of fyn was also observed in Concanavalin-A-primed peripheral blood lymphocytes stimulated with PRL and in Nb2 cells incubated with anti-PRLR antibodies. The activation of fyn by PRL stimulation correlated with Nb2 cell proliferation. Immunoblot analysis of anti-fyn and anti-PRLR immune complexes revealed an association between each PRLR isoform and p59fyn. These studies demonstrate for the first time an association between the PRLR and a src family protein tyrosine kinase affiliated with signal transduction.
The Synthesis, Stereochemistry, and Biology of 16-Hetero and 17-Oxa-D-homo Steroids (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis, Stereochemistry, and Biology of 16-Hetero and 17-Oxa-D-homo SteroidsJohn S. BaranCite this: J. Med. Chem. 1967, 10, 6, 1039–1047Publication Date (Print):November 1, 1967Publication History Published online1 May 2002Published inissue 1 November 1967https://pubs.acs.org/doi/10.1021/jm00318a011https://doi.org/10.1021/jm00318a011research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells (2006)

Purine nucleoside phosphorylase (PNP) deficiency in humans results in T lymphocytopenia. Forodesine, a potent inhibitor of PNP, was designed based on the transition-state structure stabilized by the enzyme. Previous studies established that forodesine in the presence of deoxyguanosine (dGuo) inhibits the proliferation of T lymphocytes. A phase 1 clinical trial of forodesine in T-cell malignancies demonstrated significant antileukemic activity with an increase in intracellular dGuo triphosphate (dGTP). High accumulation of dGTP in T cells may be dependent on the levels of deoxynucleoside kinases. Because B-cell chronic lymphocytic leukemia (B-CLL) cells have high activity of deoxycytidine kinase (dCK), we hypothesized that these lymphocytes would respond to forodesine. This postulate was tested in primary lymphocytes during in vitro investigations. Lymphocytes from 12 patients with CLL were incubated with forodesine and dGuo. These CLL cells showed a wide variation in the accumulation of intracellular dGTP without any effect on other deoxynucleotides. This was associated with DNA damage-induced p53 stabilization, phosphorylation of p53 at Ser15, and activation of p21. The dGTP accumulation was related to induction of apoptosis measured by caspase activation, changes in mitochondrial membrane potential, and PARP cleavage. Based on these data, a phase 2 clinical trial of forodesine has been initiated for CLL patients.
Modelling Uncertainty in the Game of Go (2004)

Go is an ancient oriental game whose complexity has defeated at-tempts to automate it. We suggest using probability in a Bayesian sense to model the uncertainty arising from the vast complexity of the game tree. We present a simple conditional Markov ran-dom eld model for predicting the pointwise territory outcome of a game. The topology of the model re\nects the spatial structure of the Go board. We describe a version of the Swendsen-Wang pro-cess for sampling from the model during learning and apply loopy belief propagation for rapid inference and prediction. The model is trained on several hundred records of professional games. Our experimental results indicate that the model successfully learns to predict territory despite its simplicity. 1
Mass Spectrometric Investigation of Molecular Variability of Grass Pollen Group 1 Allergens (2009)

Natural grass pollen allergens exhibit a wide variety of isoforms. Precise characterization of such microheterogeneity is essential to improve diagnosis and design appropriate immunotherapies. Moreover, standardization of allergen vaccine production is a prerequisite for product safety and efficiency. Both qualitative and quantitative analytical methods are thus required to monitor and control the huge natural variability of pollens, as well as final product quality. A proteomic approach has been set up to investigate in depth the structural variability of five group 1 allergens originating from distinct grass species (Ant o 1, Dac g 1, Lol p 1, Phl p 1, and Poa p 1). Whereas group 1 is the most conserved grass pollen allergen, great variations were shown between the various isoforms found in these five species using mass spectrometry, with many amino acid exchanges, as well as variations in proline hydroxylation level and in main N-glycan motifs. The presence of O-linked pentose residues was also demonstrated, with up to three consecutive units on the first hydroxyproline of Ant o 1. In addition, species-specific peptides were identified that might be used for product authentication or individual allergen quantification. Lastly, natural or process-induced modifications (deamidation, oxidation, glycation) were evidenced, which might constitute useful indicators of product degradation.
Stability of Common Analytes in Urine Refrigerated for 24 h before Automated Analysis by Test Strips (2000)

The stability of the automated dipstick urinalysis varies with the substance tested. After refrigeration for 24 h, there is a risk of false-positive results for protein, false-negative results for leukocytes and erythrocytes, and little effect on glucose, nitrite, and ketone values.
Fundamentals of Short-Range Fm Radar (2003)

Here's a unique new resource that offers you a solid understanding of the fundamental theory, operation principles and applications of short-range frequency modulated continuous wave (FMCW) radar. You learn how to choose the structural scheme of short-range FM radar, and determine the optimal algorithm of useful signal processing necessary for ensuring the technical characteristic of radar. Moreover, this practical reference shows you how to ensure the minimum level of radar signal parasitic amplitude, calculate modulation signal distortion, and compensate for nonlinear distortion. For the first time in any book, you find detailed coverage of the theory and calculations of autodyne radar, helping you avoid typical mistakes with your work in this area. Other critical discussions include the parameters of UHF unit output signals and the principles of regime optimization. Supported over 750 equations, the book saves you valuable time in solving problems, so you can focus on your analysis. The original application of low-cost, lightweight FMCW radar technology was in proximity fuzes for artillery projectiles, where production lots of thousands or more were typical, with small size, low cost, reliability and freedom from jamming vulnerability were essential features. Little has been published in this area because of the military nature of the application. More recently, as the technology has become familiar to engineers in civil areas, applications to industrial measurements and vehicle navigation have become apparent. Here, also, the advantages of small size and low cost make FMCW radar technology suitable for large-scale use in the industrial and consumer market. With the information available for the first time in this book, many new applications will be found for short-range FMCW radar.
Prognosis for polypoidal melanoma is determined by primary tumor thickness (1986)

Survival of 23 patients with polypoidal malignant melanomas was compared with an identical number of patients with nonpolypoidal melanomas of similar thickness, stage, and location. Five-year survivals for the two groups were not significantly different. The dominant prognostic factor leading to the adverse prognosis associated with polypoidal melanomas was the primary tumor thickness (all greater than 1.70 mm) and not the polypoidal morphologic configuration per se.
A robust autonomous mobile forklift pallet recognition (2010)

A visual pallet recognition system based on the accurate color segmentation is proposed. The basic idea is to get the pallet color feature samples from the images in working environment before the autonomous mobile forklift works. Then the algorithms of morphological filtering, Sobel edge detection and Hough tranform are used to get the pallet forking side. At last, according to two corners of the forking side, the pallet midpoint coordinates of the forking part and the direction of the forking side are calculated, which are the pose provided for the autonomous mobile forklift engagement. Experimental results show that the visual recogition system has good real-time and robustness.
Synthesis of <sup>3</sup>H‐labelled levamisole (1987)

Abstract Levamisole, the levo isomer of tetramisole, is a potent anthelmintic also showing immunotropic properties. Renewed interest in the latter domain necessitated the synthesis of specifically 3 H‐labelled levamisole of high specific activity. Racemic 1‐(2‐bromophenyl)‐1,2‐ethane diamine dihydrochloride ( V ) was obtained via bromination of 1‐(2‐bromophenyl)ethanone ( I ), followed by reaction with 2,5‐pyrrolidinedione, Leuckart amination and hydrolysis. The racemate was then resolved by successive salt formation with (S)‐(‐) and (R)‐(+) tartaric acid. The liberated (S)‐(+)‐base of VI was dehalogerated with approximately 30 Ci of tritium gas and immediately ring‐closed with carbon disulfide to VIII . The HPLC‐purified material was finally cyclized with 1,2‐dibromo ethane to (S)‐(‐)‐2,3,5,6‐tetrahydro‐6‐[2‐T]phenyl‐imidazo‐(2,1‐b)‐thiazole IX and the isomerically ringclosed (S)‐2,3,5,6‐tetrahydro‐5‐[2‐T] phenyl‐imidazo‐(2,1‐b)‐thiazole X , of which levamisole IX was isolated via HPLC. The radiochemical yield over the cyclization steps was 28.2 %, the specific activity was 10.82 Ci/mmol, and the product was 99.9 % HPLC pure.
Angular dependence of<i>J</i><sub>c</sub>for YBCO coated conductors at low temperature and very high magnetic fields (2009)

We present very high field angle dependent critical current density (Jc) data for three recently obtained YBa2Cu3O7−x (YBCO) coated conductors used in the construction of high field solenoids. We find that strongly correlated pins, such as BaZrO3 (BZO) nanorods, while yielding strong c-axis peaks at 77 K, produce almost no measurable contribution at 4 K. Raising the field from <5 to 30 T at 4 K causes a marked transition from a Ginzburg–Landau-like Jc(θ) at low fields to a marked cusp-like behavior at high fields. Transmission electron micrographs show that all samples contain a high density of stacking faults which strengthen the plane correlated pinning parallel to the ab planes produced by the intrinsic ab-plane pinning of the Cu–O charge reservoir layers.
Design of a Flexible Reactivation Cell for Safe Power-Mode Transition in Power-Gated Circuits (2008)

Power-gating is one of the most promising and widely adopted solutions for controlling sub-threshold leakage power in nanometer circuits. Although single-cycle power-mode transition reduces wake-up latency, it develops large discharge current spikes, thereby causing IR-drop and inductive ground bounce for the neighboring circuit blocks, which can suffer from power plane integrity degradation. We propose a new reactivation solution that helps in controlling power supply fluctuations and achieving minimum reactivation times. Our structure limits the turn-on current below a given threshold through a sequential activation of the sleep transistors (STs), which are connected in parallel and sized using a novel optimal sizing algorithm. We also introduce a distributed physical implementation, which allows minimum layout disruption after ST insertion and minimizes routing congestion.
Design, Synthesis, and Qualitative Structure–Activity Evaluations of Novel β-Secretase Inhibitors as Potential Alzheimer’s Drug Leads (2011)

We have identified highly selective imidazopyridines armed with benzimidazol and/or arylimidazole as potent β-secretase inhibitors. The most effective and selective analogues demonstrated low nanomolar potency for the BACE1 enzyme as measured by FRET and cell-based (ELISA) assays and exhibited comparable affinity (KI) and high ligand efficiency (LE). In addition, these motifs were highly selective (>200) against the structurally related aspartyl protease BACE2. Our design strategy followed a traditional SAR approach and was supported by molecular modeling studies based on the previously reported hydroxyethylene transition state inhibitor derived from isophthalic acid I. Of the most potent compounds, 34 displayed an IC50 for BACE1 of 18 nM and exhibited cellular activity with an EC50 of 37 nM in the cell-based ELISA assay, as well as high affinity (KI=17 nM) and ligand efficiency (LE=1.7 kJ/mol). Compound 34 was found to be 204-fold more selective for BACE1 compared to the closely related aspartyl protease BACE2.
Ultra-Wideband Phased Array for Millimeter-Wave 5G and ISM (2016)

Growing mobile data consumption has prompted the exploration of the millimeter-wave spectrum for large bandwidth, high speed communications. However, the allocated bands are spread across a wide swath of spectrum: fifth generation mobile architecture (5G): 28, 38, 39, 64-71 GHz, as well as Industrial, Scientific, and Medical bands (ISM): 24 and 60 GHz. Moreover, high gain phased arrays are required to overcome the significant path loss associated with these frequencies. Further, it is necessary to incorporate several of these applications in a single, small size and low cost platform. To this end, we have developed a scanning, Ultra-Wideband (UWB) array which covers all 5G, ISM, and other mm-W bands from 24-72 GHz. Critically, this is accomplished using mass-production Printed Circuit Board (PCB) fabrication.
4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors (2009)

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an enzyme that catalyzes the hydrolysis of 3'-phosphotyrosyl bonds. Such linkages form in vivo when topoisomerase I (Top1) processes DNA. For this reason, Tdp1 has been implicated in the repair of irreversible Top1-DNA covalent complexes. Tdp1 inhibitors have been regarded as potential therapeutics in combination with Top1 inhibitors, such as the camptothecin derivatives, topotecan, and irinotecan, which are used to treat human cancers. Using a novel high-throughput screening assay, we have identified the C21-substituted progesterone derivative, NSC 88915 (1), as a potential Tdp1 inhibitor. Secondary screening and cross-reactivity studies with related DNA processing enzymes confirmed that compound 1 possesses specific Tdp1 inhibitory activity. Deconstruction of compound 1 into discrete functional groups reveals that both components are required for inhibition of Tdp1 activity. Moreover, the synthesis of analogues of compound 1 has provided insight into the structural requirements for the inhibition of Tdp1. Surface plasmon resonance shows that compound 1 binds to Tdp1, whereas an inactive analogue fails to interact with the enzyme. On the basis of molecular docking and mechanistic studies, we propose that these compounds are competitive inhibitors, which mimics the oligonucleotide-peptide Tdp1 substrate. These steroid derivatives represent a novel chemotype and provide a new scaffold for developing small molecule inhibitors of Tdp1.
Loopback DFT for Low-Cost Test of Single-VCO-Based Wireless Transceivers (2008)

This article discusses a loopback DFT test approach for RFIC chips that provides quick, economical test results at the wafer level. By performing RF testing before chip packaging, the authors reduce test cost. They show that test yield on the ATE for Texas Instruments' RFIC devices is high when this loopback DFT approach is used.
Ranitidine and high concentrations of phenylpropanolamine cross react in the EMIT monoclonal amphetamine/methamphetamine assay. (1989)

Journal Article Ranitidine and high concentrations of phenylpropanolamine cross react in the EMIT monoclonal amphetamine/methamphetamine assay. Get access G F Grinstead G F Grinstead Marshfield Medical Center Laboratory, WI 54449 Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 35, Issue 9, 1 September 1989, Pages 1998–1999, https://doi.org/10.1093/clinchem/35.9.1998 Published: 01 September 1989
Excision repair of ultraviolet-irradiated deoxyribonucleic acid in plasmolyzed cells of Escherichia coli (1976)

A system of cells made permeable by treatment with high concentrations of surcrose (plasmolysis) has been exploited to study the excision repair of ultraviolet-irradiated deoxyribonucleic acid in Escherichia coli. It is demonstrated that adenosine 5'-triphosphate is required for incision breaks to be made in the bacterial chromosome as well as in covalently closed bacteriophage lambda deoxyribonucleic acid. After plasmolysis, uvrC mutant strains appear as defective in the incision step as the uvrA-mutated strains. This is in contrast to the situation in intact cells where uvrC mutants accumulate single-strand breaks during postirradiation incubation. These observations have led to the proposal of a model for excision repair, in which the ultraviolet-specific endonuclease, coded for by the uvrA and uvrB genes, exists in a complex with the uvrC gene product. The complex is responsible for the incision and possibly also the excision steps of repair. The dark-repair inhibitors acriflavine and caffeine are both shown to interfere with the action of the adenosine 5'-triphosphate-dependent enzyme.
Cross-talk between leukemic and endothelial cells promotes angiogenesis by VEGF activation of the Notch/Dll4 pathway (2012)

Angiogenesis is suggested to be important for leukemogenesis and chemosensitivity in acute myeloid leukemia (AML). The vascular endothelial growth factor (VEGF) and Notch/Dll4 pathways have been identified as critical in the regulation of embryonic vascular development and tumor angiogenesis. However, the potential role of the Notch/Dll4 pathway in leukemia-endothelium cross-talk and its functional link with VEGF remains obscure. This study assessed the expression of VEGF and Notch/Dll4 pathway molecules in primary AML and investigated their biological function in the coculture of endothelial cells with AML cells. The results demonstrated that bone marrow vascularity in the newly diagnosed AML patients was increased and correlated with high VEGF and Dll4 expression. Patients with untreated AML expressed higher levels of VEGFR2, Notch1, Dll4 and Hes1 than healthy controls. Moreover, the activation of the Notch/Dll4 pathway is associated with poor prognosis in AML. In addition, AML cells were shown to increase endothelial cell proliferation in Transwell coculture. This was associated with concomitant activation of the Notch/Dll4 pathway and upregulation of its downstream genes, such as matrix metalloproteinases, resulting in the enhancement of endothelial cell migration and tube formation. Our study also showed that upregulation of Dll4 expression in AML cells by cDNA transfection suppressed VEGF-induced endothelial cell proliferation and angiogenesis in direct contact coculture. These results elucidate a novel mechanism by which the interplay between AML and endothelial cells promotes angiogenesis through the Notch/Dll4 pathway. Modulation of this pathway may, therefore, hold promise as a novel antiangiogenic strategy for the treatment of AML.
Role of the galactose lectin of Entamoeba histolytica in adherence-dependent killing of mammalian cells (1991)

Entamoeba histolytica extracellular killing of host cells is contact dependent. Adherence to human colonic epithelial cells and mucins is mediated by a galactose-specific lectin. The effect on cytotoxicity of a panel of monoclonal antibodies (MAb) directed against the galactose lectin was tested. As expected, those MAb which inhibited adherence also decreased cytotoxicity. However, one antilectin MAb blocked cytotoxicity after adherence had occurred, indicating that the lectin has a role in cell killing that is distinct from its adherence function.