gebhart/patrepeval huggingface dataset:
Design of intelligent lighting control system (2011)

In order to deal with the shortcoming of poor light effect in the scene control, a new intelligent lighting control system was designed based on the CIE gamut standard and the dual-CPU Embedded System Architecture. By employing light adjustment of the multi-colored LED, color control and scene settings of the assembled light, the intelligent lighting control system with the graphic user interface and the touch-control technology is designed and realized. Besides the easy operation, the flexible and reliable control makes the system widely used in the entertainment places, such as hotel, chamber, office building, urban landscape, etc.
Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis (2004)

Radiation therapy is a widely used cancer treatment, but it causes side effects even when localized radiotherapy is used. Extensive apoptosis of microvascular endothelial cells of the lamina propria is the primary lesion initiating intestinal radiation damage after abdominal radiation therapy. Many in vitro studies suggest that angiopoietin-1 (Ang1) has potential therapeutic applications in enhancing endothelial cell survival. For in vivo use, we developed a soluble, stable, and potent Ang1 variant, COMP-Ang1. COMP-Ang1 is more potent than native Ang1 in phosphorylating the Tie2 receptor in lung endothelial cells in vivo. Interestingly, COMP-Ang1 administered i.v. was mainly localized to microvascular endothelial cells of the intestinal villi and lung but not to microvascular endothelial cells of the liver. In irradiated mice, i.v. COMP-Ang1 protected against radiation-induced apoptosis in microcapillary endothelial cells of the intestinal villi and prolonged survival. Thus, COMP-Ang1 could be used as a therapeutic protein for specific protection against endothelial cell injury.
Incorporation of Primary Amines into a Polyester Chain by a Combination of Chemical and Lipase‐Catalyzed ε‐Caprolactone Ring‐Opening Processes (2007)

Abstract A simple chemoenzymatic strategy for the incorporation of bioactive and suitably functionalized molecules into a polyester chain has been developed. The protocol involves first the reaction of a primary amine with ε‐caprolactone to give an amide carrying a terminal primary hydroxy group, followed by the enzymatic growth of the polymeric chain triggered by Novozym 435. This method is versatile and easy to handle and is suitable for the incorporation of different amines into polyesters, as has been shown with the model compounds benzylamine and tryptamine, the bioactive compound N ‐deacetylthiocolchicine and the functionalized propargylamine and tyramine .
High Breakdown Voltage Undoped AlGaN–GaN Power HEMT on Sapphire Substrate and Its Demonstration for DC–DC Converter Application (2004)

Undoped AlGaN-GaN power high electron mobility transistors (HEMTs) on sapphire substrate with 470-V breakdown voltage were fabricated and demonstrated as a main switching device for a high-voltage dc-dc converter. The fabricated power HEMT realized a high breakdown voltage with a field plate structure and a low on-state resistance of 3.9 m/spl Omega//spl middot/cm/sup 2/, which is 10 /spl times/ lower than that of conventional Si MOSFETs. The dc-dc converter operation of a down chopper circuit was demonstrated using the fabricated device at the input voltage of 300 V. These results show the promising possibilities of the AlGaN-GaN power HEMTs on sapphire substrate for future switching power devices.
The influence of antisense RNA on transcriptional mapping of the 5' terminus of a baculovirus RNA (1991)

S1 nuclease protection and primer extension analyses were used to determine the 5' end of the Autographa californica nuclear polyhedrosis virus 603 open reading frame (ORF) transcript upstream of and on the opposite strand to the polyhedrin gene. These analyses suggested that the 5' end of the 603 ORF was located near the initiation site for polyhedrin gene transcription. Primer extension products of reverse transcription of 603 RNA were dependent on the presence of the TAAG sequence, an essential polyhedrin promoter element. The results could be interpreted as indicating bidirectional transcription from the TAAG element. However, the data could also be due to an artefact of antisense transcripts and RNA duplex formation in this region. Since the bidirectional transcriptional model is not consistent with other mapping data and Northern blot analysis, we conclude that the presence of antisense RNA can result in mapping artefacts and that caution must be taken in interpreting data where overlapping sense and antisense RNAs are present.
Pemetrexed in advanced non-small-cell lung cancer (2010)

Pemetrexed is an effective treatment for advanced NSCLC, with an overall favorable toxicity profile. There is growing evidence that, in patients treated with pemetrexed, nonsquamous tumors have improved outcomes compared to squamous cell tumors. Pemetrexed may also have a role in maintenance therapy for NSCLC.
Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection (2010)

Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38(+) HLA-DR(+) CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.
Receptors for transferrin in pathogenic bacteria are specific for the host's protein (1990)

Transferrin receptors detected by a solid-phase binding assay were shown to be specific for the host's transferrin in the representative bacterial pathogens Neisseria meningitidis (human), Pasteurella haemolytica (bovine), and Actinobacillus pleuropneumoniae (porcine). Consistent with the receptor specificity, iron-deficient bacteria were only capable of utilizing transferrin from the host as a source of iron for growth.
Flycon (2018)

We propose a real-time method for the infrastructure-free estimation of articulated human motion. The approach leverages a swarm of camera-equipped flying robots and jointly optimizes the swarm's and skeletal states, which include the 3D joint positions and a set of bones. Our method allows to track the motion of human subjects, for example an athlete, over long time horizons and long distances, in challenging settings and at large scale, where fixed infrastructure approaches are not applicable. The proposed algorithm uses active infra-red markers, runs in real-time and accurately estimates robot and human pose parameters online without the need for accurately calibrated or stationary mounted cameras. Our method i) estimates a global coordinate frame for the MAV swarm, ii) jointly optimizes the human pose and relative camera positions, and iii) estimates the length of the human bones. The entire swarm is then controlled via a model predictive controller to maximize visibility of the subject from multiple viewpoints even under fast motion such as jumping or jogging. We demonstrate our method in a number of difficult scenarios including capture of long locomotion sequences at the scale of a triplex gym, in non-planar terrain, while climbing and in outdoor scenarios.
Microwave-Assisted Catalytic Intermolecular Hydroamination of Alkynes (2001)

Irradiation of reaction mixtures containing an alkyne, an amine, and a catalytic amount of Cp2TiMe2 in toluene with microwaves at a frequency of 2.45 GHz and a power output of 180−300 W results in fast reactions to give the corresponding hydroamination products. The initially formed imines can easily be reduced to secondary amines by use of H2/Pd, LiAlH4, or NaCNBH3/p-TsOH. The microwave-assisted hydroamination reactions go to completion within one tenth (or less) of the time required for reactions run conventionally in an oil bath at 105 °C. By using the microwave technology, it is possible to achieve turnover frequencies TOF > 10 h−1. Furthermore, when Cp2TiMe2 is used as the catalyst, hydroamination products of terminal alkynes can be isolated in reasonable yields for the first time. The addition of amines to terminal alkynes gives access to both the Markovnikov and the anti-Markovnikov products. Observed regioselectivities are different for terminal aryl- and alkylalkynes.
Sucrose Octasulfate Selectively Accelerates Thrombin Inactivation by Heparin Cofactor II (2010)

Inactivation of thrombin (T) by the serpins heparin cofactor II (HCII) and antithrombin (AT) is accelerated by a heparin template between the serpin and thrombin exosite II. Unlike AT, HCII also uses an allosteric interaction of its NH(2)-terminal segment with exosite I. Sucrose octasulfate (SOS) accelerated thrombin inactivation by HCII but not AT by 2000-fold. SOS bound to two sites on thrombin, with dissociation constants (K(D)) of 10 +/- 4 microm and 400 +/- 300 microm that were not kinetically resolvable, as evidenced by single hyperbolic SOS concentration dependences of the inactivation rate (k(obs)). SOS bound HCII with K(D) 1.45 +/- 0.30 mm, and this binding was tightened in the T.SOS.HCII complex, characterized by K(complex) of approximately 0.20 microm. Inactivation data were incompatible with a model solely depending on HCII.SOS but fit an equilibrium linkage model employing T.SOS binding in the pathway to higher order complex formation. Hirudin-(54-65)(SO(3)(-)) caused a hyperbolic decrease of the inactivation rates, suggesting partial competitive binding of hirudin-(54-65)(SO(3)(-)) and HCII to exosite I. Meizothrombin(des-fragment 1), binding SOS with K(D) = 1600 +/- 300 microm, and thrombin were inactivated at comparable rates, and an exosite II aptamer had no effect on the inactivation, suggesting limited exosite II involvement. SOS accelerated inactivation of meizothrombin 1000-fold, reflecting the contribution of direct exosite I interaction with HCII. Thrombin generation in plasma was suppressed by SOS, both in HCII-dependent and -independent processes. The ex vivo HCII-dependent process may utilize the proposed model and suggests a potential for oversulfated disaccharides in controlling HCII-regulated thrombin generation.
A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activitiesPhilip S. Portoghese, Dennis L. Larson, Lawrence M. Sayre, David S. Fries, and A. E. TakemoriCite this: J. Med. Chem. 1980, 23, 3, 233–234Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/jm00177a002https://doi.org/10.1021/jm00177a002research-articleACS PublicationsRequest reuse permissionsArticle Views398Altmetric-Citations248LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In Situ Cues for ADHD Parenting Strategies Using Mobile Technology (2014)

Parenting is always demanding, but families coping with neurodevelopmental disorders, such as ADHD, experience unique challenges. To address these challenges, research in the area of Parental Behavioral Therapy is accelerating. This type of therapy focuses on behavioral strategies that, if practiced
Synthesis of a new copper(i) complex, [Cu(tmdcbpy)2]+ (tmdcbpy = 4,4′,6,6′-tetramethyl-2,2′-bipyridine-5,5′-dicarboxylic acid), and its application to solar cells (2002)

A newly synthesized copper(I) complex, [Cu(tmdcbpy)2]+ (tmdcbpy = 4,4′,6,6′-tetramethyl-2,2′-bipyridine-5,5′-dicarboxylic acid), was applied to a solar cell with TiO2, which provided successful results, a photocurrent of about 4 mA cm−2, photovoltage of 630 mV and an IPCE (incident monochromatic photon-to-current conversion efficiency) value of 30%, under visible light irradiation from a AM 1.5G sunlight simulator (100 mW cm−2).
Development of Integrally Molded Bipolar Plates for All-Vanadium Redox Flow Batteries (2016)

All-vanadium redox flow batteries (VRBs) are potential energy storage systems for renewable power sources because of their flexible design, deep discharge capacity, quick response time, and long cycle life. To minimize the energy loss due to the shunt current, in a traditional design, a flow field is machined on two electrically insulated frames with a graphite plate in between. A traditional bipolar plate (BP) of a VRB consists of many components, and thus, the assembly process is time consuming. In this study, an integrally molded BP is designed and fabricated to minimize the manufacturing cost. First, the effects of the mold design and injection parameters on frame formability were analyzed by simulation. Second, a new graphite plate design for integral molding was proposed, and finally, two integrally molded BPs were fabricated and compared. Results show that gate position significantly affects air traps and the maximum volume shrinkage occurs at the corners of a BP. The volume shrinkage can be reduced using a large graphite plate embedded within the frame.
The relationship between growth, profitability, and firm value (1987)

Abstract This research examined predictions drawn from value‐based planning models. Results indicate that profitability and growth do influence shareholder value in the manner predicted; however, the relationships are conditional. This study also shows that, the market‐to‐book value of equity ratio and Tobin's q‐ratio are theoretically and empirically, equivalent measures of value creation.
Endotoxin tolerance: regulation of cytokine production and cellular changes in response to endotoxin application in cancer patients. (1993)

Endotoxin (lipopolysaccharide, LPS) has the property of inducing tolerance to its own biological effects. This phenomenon has been extensively studied in animal models but only few studies exist on the regulation in humans. Here we describe experiments designed to determine the cytokine regulation and cellular changes in humans during induction of LPS tolerance after repeated LPS injections. Intravenous administration of purified LPS Salmonella abortus equi to cancer patients induces high amounts of circulating tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), granulocyte colony-stimulating factor (G-CSF), and macrophage colony-stimulating factor (M-CSF). Repeated injections of LPS at daily intervals resulted in a marked downregulation of the cytokine response and in the case of TNF-alpha, IL-8, G-CSF, and M-CSF the cytokine response was reduced to baseline levels. In contrast, significant increases in serum IL-6 were detected up to day 5 of repeated LPS injections. Hematological changes included transient decreases in WBCs affecting granulocytes, monocytes, and lymphocytes, followed by a marked granulocytosis. The drop in WBCs remained unaltered throughout the 5 day course of repeated LPS injections whereas the granulocyte overshoot recovery diminished gradually. When PBMCs of the cancer patients were restimulated ex vivo a marked enhancement of the capacity to produce TNF-alpha, IL-113, and IL-6 occurred, which is in contrast to the decreasing TNF-alpha serum levels obtained in vivo. In parallel, a shift in monocyte subpopulations from CD14+/CD16- to CD14+/CD16+ cells was observed. The data provide evidence that different mechanisms are implicated in the cytokine downregulation following repeated LPS injections to cancer patients. Furthermore, PBMCs from LPS tolerant patients do not demonstrate a reduction in their capacity to produce cytokines.
Inflammation and Collagenase Production in Rats with Adjuvant Arthritis Reduced with 13- <i>cis</i> -Retinoic Acid (1983)

Oral administration of 13-cis-retinoic acid (40 or 160 milligrams per kilogram of body weight daily) significantly reduced the inflammation associated with developing and established adjuvant arthritis, an experimentally induced arthritis in rats that resembles human rheumatoid arthritis. The amount of collagenase secreted in tissue culture by adherent cells isolated from the inflamed joints of adjuvant rats treated with 13-cis-retinoic acid also decreased as compared to the amount secreted by cells from vehicle-treated adjuvant rats. Collagenase is important in the joint destruction accompanying rheumatoid arthritis. The successful use of retinoids in the treatment of this proliferative but nonmalignant disorder demonstrates a new application of these compounds.
Double-Enzymes-Mediated Bioluminescent Sensor for Quantitative and Ultrasensitive Point-of-Care Testing (2017)

We report an ultrasensitive, quantitative, and rapid bioluminescent immunosensor (ABS) for point-of-care testing (POCT) of the disease biomarker in clinical samples using double enzymes including alkaline phosphatase (ALP) and luciferase. In the presence of the biomarker, the ALP attached on the surface of immuno-nanocomplex dephosphorylates adenine triphosphate (ATP), subsequently inhibiting the ATP-luciferin-luciferase bioluminescent reaction. The highly sensitive response of ATP (picomolar level) allows for ultrasensitive detection of biomarker via the effective change of the bioluminescence intensity through ALP- and luciferase-catalyzed reactions, which can be quantitatively determined by a portable ATP detector. This ABS fulfills the criteria for POCT that performs sensitive (femtomolar level of biomarkers) and quantitative measurement quickly (less than 1 h) with minimal equipment (portable detector).
Recent Advances in Interface Engineering for Planar Heterojunction Perovskite Solar Cells (2016)

Organic-inorganic hybrid perovskite solar cells are considered as one of the most promising next-generation solar cells due to their advantages of low-cost precursors, high power conversion efficiency (PCE) and easy of processing. In the past few years, the PCEs have climbed from a few to over 20% for perovskite solar cells. Recent developments demonstrate that perovskite exhibits ambipolar semiconducting characteristics, which allows for the construction of planar heterojunction (PHJ) perovskite solar cells. PHJ perovskite solar cells can avoid the use of high-temperature sintered mesoporous metal oxides, enabling simple processing and the fabrication of flexible and tandem perovskite solar cells. In planar heterojunction materials, hole/electron transport layers are introduced between a perovskite film and the anode/cathode. The hole and electron transporting layers are expected to enhance exciton separation, charge transportation and collection. Further, the supporting layer for the perovskite film not only plays an important role in energy-level alignment, but also affects perovskite film morphology, which have a great effect on device performance. In addition, interfacial layers also affect device stability. In this review, recent progress in interfacial engineering for PHJ perovskite solar cells will be reviewed, especially with the molecular interfacial materials. The supporting interfacial layers for the optimization of perovskite films will be systematically reviewed. Finally, the challenges remaining in perovskite solar cells research will be discussed.
NOTES ON THE LARVA OF HETEROCAMPA PULVEREA, G. & R. (1880)

Length when at rest, 1.25 inches; in shape tapering slightly from the middle forward, but more rapidly from that point backward ; the body deeper than broad. General color bright clear green, a little spotted with white, marked as follows : head gray, a little lighter through the centre ; joint I contains two dark purplish black warts on the dorsum, reddish purple at the base, the space between them whitish.
Proton-coupled protein transport through the anthrax toxin channel (2008)

Anthrax toxin consists of three proteins (approx. 90kDa each): lethal factor (LF); oedema factor (OF); and protective antigen (PA). The former two are enzymes that act when they reach the cytosol of a targeted cell. To enter the cytosol, however, which they do after being endocytosed into an acidic vesicle compartment, they require the third component, PA. PA (or rather its proteolytically generated fragment PA63) forms at low pH a heptameric beta-barrel channel, (PA63)7, through which LF and OF are transported--a phenomenon we have demonstrated in planar phospholipid bilayers. It might appear that (PA63)7 simply forms a large hole through which LF and OF diffuse. However, LF and OF are folded proteins, much too large to fit through the approximately 15A diameter (PA63)7 beta-barrel. This paper discusses how the (PA63)7 channel both participates in the unfolding of LF and OF and functions in their translocation as a proton-protein symporter.
A one penny imputed genome from next generation reference panels (2018)

Abstract Genotype imputation is commonly performed in genome-wide association studies because it greatly increases the number of markers that can be tested for association with a trait. In general, one should perform genotype imputation using the largest reference panel that is available because the number of accurately imputed variants increases with reference panel size. However, one impediment to using larger reference panels is the increased computational cost of imputation. We present a new genotype imputation method, Beagle 5.0, which greatly reduces the computational cost of imputation from large reference panels. We compare Beagle 5.0 with Beagle 4.1, Impute4, Minimac3, and Minimac4 using 1000 Genomes Project data, Haplotype Reference Consortium data, and simulated data for 10k, 100k, 1M, and 10M reference samples. All methods produce nearly identical accuracy, but Beagle 5.0 has the lowest computation time and the best scaling of computation time with increasing reference panel size. For 10k, 100k, 1M, and 10M reference samples and 1000 phased target samples, Beagle 5.0’s computation time is 3× (10k), 12× (100k), 43× (1M), and 533× (10M) faster than the fastest alternative method. Cost data from the Amazon Elastic Compute Cloud show that Beagle 5.0 can perform genome-wide imputation from 10M reference samples into 1000 phased target samples at a cost of less than one US cent per sample. Beagle 5.0 is freely available from https://faculty.washington.edu/browning/beagle/beagle.html .
Assessment of Pancreas Safety in the Development Program of Once-Weekly GLP-1 Receptor Agonist Dulaglutide (2017)

The exposure-adjusted incidence rate of acute pancreatitis in dulaglutide-treated patients was similar to the rates with placebo, with few reported cases during the entire program.
Cardiomyoplasty (1994)

The authors present their experience with cardiomyoplasty in 25 patients. They describe the early and late results, control of hemodynamic changes, and the optimal regimen for stimulation of the muscular graft.