gebhart/patrepeval huggingface dataset:
Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (1997)

Pharmacological properties of NK-104 ((+)-monocalcium bis¿(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl++ +]-3,5-dihydroxy-6- heptenoate¿, CAS 147526-32-7), a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, were investigated. The kinetic study, using rat liver microsomal HMG-CoA reductase, revealed that NK-104 is a competitive inhibitor of HMG-CoA reductase with a Ki of 1.7 nmol/l. To examine the inhibitory effect on sterol synthesis in vivo, de novo synthesis of sterols from [14C]acetate 3 h after oral administration of NK-104 was measured in rats. NK-104 showed marked inhibition in liver (ED50 0.13 mg/kg) and in ileum (ED50 0.20 mg/kg), but much weaker in the other tissues. The inhibitory effect of NK-104 on liver sterol synthesis lasted over 6 h, while that of pravastatin and simvastatin disappeared 6 h after administration of the drugs twice the ED50s. Due to induction of HMG-CoA reductase, initial suppression of hepatic sterol synthesis by pravastatin and simvastatin was compensated, and the cumulative change in hepatic sterol synthesis during 12 h after drug administration was remarkably negative only with long-acting NK-104. Hypolipidemic effects of NK-104 (0.03, 0.1, 0.3 and 1 mg/kg p.o. for 2 weeks) were examined in beagle dogs. NK-104 reduced plasma total cholesterol dose-dependently (13.1, 18.5 and 20.2% at doses of 0.1, 0.3 and 1 mg/kg, respectively), and also plasma triglycerides by 0.1 mg/kg or more. Pravastatin (1 and 3 mg/kg) and simvastatin (3 mg/kg) lowered plasma total cholesterol (14.0, 15.4 and 17.4%, respectively), but did not significantly affect plasma triglyceride levels. These results indicate that NK-104 is a potent, liver-selective, long-acting HMG-CoA reductase inhibitor with a high cholesterol- and triglyceride-lowering potency.
Profit Maximization Mechanism and Data Management for Data Analytics Services (2018)

With the advancement and emergence of new network services, such as social network, Internet of Things, and crowd-sensing, large volume of diverse data is collected, shared, and leveraged to develop analytics services. The data analytics service has become a key commodity that can be traded among various economic entities. In this paper, we address the optimal pricing mechanisms and data management for data analytics services and further discuss the perishable services in the time varying environment. We first propose a data market model and define the data utility based on the impact of data size on the performance of data analytics, e.g., prediction and verification accuracy. For perishable services, we study the perishability of data that affects the service quality and provide a quality decay function. The data analytics services are considered as digital goods and uniquely characterized by “unlimited supply” compared to conventional goods. Therefore, we apply the Bayesian profit maximization mechanism in selling data analytics services, which is truthful, rational, and computationally efficient. The optimal service price, data amount, and service update interval are obtained to maximize the profit under different customer's valuation distributions. Finally, experimental results on realworld datasets show that our data market model and pricing mechanism effectively solve the profit maximization problem and provide useful strategies for the data analytics service provider.
Tunable 3D Hybrid Integrated Silicon Photonic External Cavity Laser (2017)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text B. Song, Y. Liu, S. Ristic, and J. Klamkin, "Tunable 3D Hybrid Integrated Silicon Photonic External Cavity Laser," in Conference on Lasers and Electro-Optics, OSA Technical Digest (online) (Optica Publishing Group, 2017), paper AM4A.3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Synthesis and Properties of Phloroglucinol−Phenol−Formaldehyde Carbon Aerogels and Xerogels (2009)

Carbon aerogels and xerogels were successfully prepared from phloroglucinol-phenol mixtures and characterized by different techniques to determine their potential. We examined the influence of the phloroglucinol/phenol ratio, reactant concentration, cure conditions, and drying method on the morphology and porosity of the samples. The gelation time was found to be independent of the phloroglucinol/phenol ratio in spite of the different reactivities of both monomers. In general, carbon aerogels have a high volume of mesopores and of micropores without diffusion restrictions. Carbon xerogels are denser materials without mesopores but with a well-developed microporosity that shows a strong molecular sieve effect. Therefore, while micro-/mesoporous carbon aerogels can be used as catalyst supports or VOC adsorbents, the microporous carbon xerogel could offer high selectivity in the separation of small molecules from gaseous mixtures.
Radio Access Network of WCDMA System (2001)

WCDMA (UTRA FDD), the main specification of the third generation mobile telecommunication, will be widely adopted in the most area of world . The standardization of WCDMA has deeply influenced on the research, development and services of radio access network (RAN). From the trend of the schedule of standardization, Release 99 must be implemented at the first step. In order to meet requirements of the mobile telecommunication environment and telecommunication services, the equipment of RAN and the corresponding software must have high spectrum efficiency, and flexible multi-service and multiform network configuration are also should be provided.
Robust design of a closed-loop supply chain network for uncertain carbon regulations and random product flows (2014)

This paper addresses a multi-period capacitated closed-loop supply chain (CLSC) network design problem subject to uncertainties in the demands and returns as well as the potential carbon emission regulations. Two promising regulatory policy settings are considered: namely, (a) a carbon cap and trade system, or (b) a tax on the amount of carbon emissions. A traditional CLSC network design model using stochastic programming is extended to integrate robust optimization to account for regulations of the carbon emissions caused by transportation. We propose a hybrid model to account for both regulatory policies and derive tractable robust counterparts under box and ellipsoidal uncertainty sets. Implications for network configuration, product allocation and transportation configuration are obtained via a detailed case study. We also present computational results that illustrate how the problem formulation under an ellipsoidal uncertainty set allows the decision maker to balance the trade-off between robustness and performance. The proposed method yields solutions that provide protection against the worst-case scenario without being too conservative.
Contractile responses of smooth muscle cells differentiated from rat neural stem cells (2002)

To characterize the functional differentiation of neural stem cells into smooth muscle cells, multipotent stem cells in the central nervous system (CNS) were isolated from rat embryonic day 14 (E14) cortex and cultured by neurosphere formation in serum-free medium in the presence of 10 ng ml(-1) of basic fibroblast growth factor. Differentiation was induced by the addition of 10 % fetal bovine serum to low-density cultures (2.5 x 10(3) cells cm(-2)). Immunological analyses and reverse transcriptase-polymerase chain reaction indicated that the differentiated cells expressed smooth-muscle-specific marker proteins such as SM-1, SM-2, and SMemb myosin heavy chains, SM-22, basic calponin and alpha-smooth-muscle actin, but not the astrocyte marker glial fibrillary acidic protein. To examine whether smooth-muscle-like cells that are differentiated from CNS stem cells possess the characteristics of contractile smooth muscle, we prepared reconstituted collagen gel fibres and measured their contractile tension. The reconstituted fibres were prepared by thermal gelation of collagen and the differentiated cells. The fibres contracted in response to treatment with KCl (80 mM), ACh (100 microM), endothelin-1 (10 nM), endothelin-2 (10 nM), and prostaglandin F2alpha (100 microM). ACh-induced contraction was partially inhibited by the L-type voltage-dependent Ca(2+) channel inhibitor nifedipine and by the intracellular Ca(2+) chelator 1,2-bis (2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid acetoxymethyl ester, the myosin light chain kinase inhibitor ML-9, the Rho kinase inhibitor Y-27632, dibutyryl cAMP and 8-bromo-cGMP. These results suggest that CNS stem cells give rise to smooth muscle cells in vitro that have an identical contractile function to smooth muscle in vivo.
Adding Selective Enhancement in Scalable Video Coding for Region-of-Interest Functionality (2006)

In this paper, we propose a lossless, graceful, and arbitrary-shaped region-of-interest (ROI) functionality for the scalable video coding in MPEG-4 Part 10 Amd. 1. Specifically, we propose a prioritized block coding scheme and a layer remapping technique. Within an enhancement layer, the prioritized block coding reshuffles the transform coefficients for ROI. Moreover, the layer remapping technique prioritizes different ROI among enhancement layers. For graceful and arbitrary-shaped properties, additional syntax are coded at the levels of slice, layer, and macroblock. To minimize overhead, an efficient representation for priority information is proposed. Experimental results show that our schemes can offer the ROI functionality over a wide range of bit rates while maintaining coding efficiency.
SpoC: Spoofing Camera Fingerprints (2021)

Thanks to the fast progress in synthetic media generation, creating realistic false images has become very easy. Such images can be used to wrap rich fake news with enhanced credibility, spawning a new wave of high-impact, high-risk misinformation campaigns. Therefore, there is a fast-growing interest in reliable detectors of manipulated media. The most powerful detectors, to date, rely on the subtle traces left by any device on all images acquired by it. In particular, due to proprietary in-camera processes, like demosaicing or compression, each camera model leaves trademark traces that can be exploited for forensic analyses. The absence or distortion of such traces in the target image is a strong hint of manipulation. In this paper, we challenge such detectors to gain better insight into their vulnerabilities. This is an important study in order to build better forgery detectors able to face malicious attacks. Our proposal consists of a GAN-based approach that injects camera traces into synthetic images. Given a GAN-generated image, we insert the traces of a specific camera model into it and deceive state-of-the-art detectors into believing the image was acquired by that model. Likewise, we deceive independent detectors of synthetic GAN images into believing the image is real. Experiments prove the effectiveness of the proposed method in a wide array of conditions. Moreover, no prior information on the attacked detectors is needed, but only sample images from the target camera.
Autodiffused Boron Emitter for N-Type Monocrystalline Si Thin-Film Solar Cells (2006)

The generation of an emitter in monocrystalline silicon thin-film solar cells by out-diffusion of dopant atoms from the growth substrate into the epitaxial layer is demonstrated. Starting with a boron-doped p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -type substrate, a porous silicon surface layer is created to permit the layer transfer (PSI process). A p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -type emitter automatically forms by out-diffusion of boron atoms during the epitaxial growth of n-type silicon films. This "autodiffusion" process creates an emitter with a moderate surface concentration of 3times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> and a junction depth of 1.1 mum. The sheet resistance is 330 Omega/square. n-type thin-film solar cells with an autodiffused boron emitter on the rear side of the cells are fabricated. An independently confirmed energy conversion efficiency of 14.5% with a short circuit current density of 33.3 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> as measured under standard testing conditions is achieved for a 4 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> large cell with a thickness of 24 mum
Fuzzy neural logic network and its learning algorithms (2002)

The paper introduces the basic features of fuzzy neural logic network. Each fuzzy neural logic network model is trained from a set of knowledge in the form of examples using one of the three learning algorithms introduced. These three learning algorithms are the delta rule controlled learning algorithm and two mathematical construction algorithms, namely, the local learning method and the global learning method. Once the fuzzy neural logic network model is constructed, it is ready to accept any unknown input from the user. With a low percentage of mismatched features, output solution can be obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Chromosomal translocation involving the beta T cell receptor gene in acute leukemia. (1988)

DNA spanning a t(7;19) chromosomal translocation breakpoint was isolated from the human T cell line SUP-T7 established from an acute lymphoblastic leukemia. Nucleotide sequence analysis showed that the point of crossover on chromosome 7 occurred immediately adjacent to joining segment J beta 1.1 within the TCR-beta gene, suggesting that this translocation resulted from an error in TCR gene rearrangement. On chromosome 19, the translocation occurred within a previously uncharacterized transcriptional unit for which we propose the name lyl-1. An approximately 1.5-kb RNA is transcribed from this gene in a wide variety of hematolymphoid cell lines. The t(7;19) results in truncation of the lyl-1 gene and production of abnormal-sized RNAs, suggesting a role for lyl-1 in the pathogenesis of this leukemia.
Cross comparison of the nonlinear impairments caused by 10Gbit/s neighboring channels on a 40Gbit/s channel modulated with various formats, and over various fiber types (2007)

We evaluate the impact of lOGbit/s NRZ channels on the performance of one 40 Gbit/s PSBT, DQPSK or DPSK channel over two fiber types. DPSK and PSBT are much less affected by 10 Gbit/s neighbors than DQPSK.
[Development of modern near infrared spectroscopic techniques and its applications]. (2000)

The historical progresses, characteristics and determined principle of near infrared spectroscopy are presented briefly. The development of modern near infrared spectroscopic instruments, chemometrics problems and applications are reviewed. Some results developed on instrument, chemometrics methods and applications of petroleum industries in our laboratory are presented briefly.
Process synchronisation in MASCOT (1979)

The MASCOT approach to programming is concerned with the build up of software in a computer, its run time operation and the testing of individual facilities. A central feature of the approach is the manner in which certain synchronisation primitive procedures and control variables are used to achieve a high degree of modularity. This paper describes MASCOT software structure and synchronisation, and includes several examples to illustrate this style of programming.
Response to RAG-Mediated V(D)J Cleavage by NBS1 and γ-H2AX (2000)

Genetic disorders affecting cellular responses to DNA damage are characterized by high rates of translocations involving antigen receptor loci and increased susceptibility to lymphoid malignancies. We report that the Nijmegen breakage syndrome protein (NBS1) and histone gamma-H2AX, which associate with irradiation-induced DNA double-strand breaks (DSBs), are also found at sites of VDJ (variable, diversity, joining) recombination-induced DSBs. In developing thymocytes, NBS1 and gamma-H2AX form nuclear foci that colocalize with the T cell receptor alpha locus in response to recombination activating gene (RAG) protein-mediated VDJ cleavage. Our results suggest that surveillance of T cell receptor recombination intermediates by NBS1 and gamma-H2AX may be important for preventing oncogenic translocations.
La rue Bab-el-Oued en 1838 (Bolle) / La mosquée Ketchaoua (Cathédrale) (1912)

Klein Henri. La rue Bab-el-Oued en 1838 (Bolle) / La mosquée Ketchaoua (Cathédrale). In: Les Feuillets d'El-Djezaïr, volume 3, 1912. Le Vieil Alger et sa banlieue. Notes complémentaires : lettres, écrits divers documents graphiques. p. 2.
MCC950, the Selective Inhibitor of Nucleotide Oligomerization Domain-Like Receptor Protein-3 Inflammasome, Protects Mice against Traumatic Brain Injury (2018)

Nucleotide oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome may intimately contribute to sustaining damage after traumatic brain injury (TBI). This study aims to examine whether specific modulation of NLPR3 inflammasome by MCC950, a novel selective NLRP3 inhibitor, confers protection after experimental TBI. Unilateral cortical impact injury was induced in young adult C57BL/6 mice. MCC950 (50 mg/kg, intraperitoneally) or saline was administration at 1 and 3 h post-TBI. Animals were tested for neurological function and then sacrificed at 24 or 72 h post-TBI. Immunoblotting and histological analysis were performed to identify markers of NLRP3 inflammasome and proapoptotic activity in pericontusional areas of the brains at 24 or 72 h post-TBI. MCC950 treatment provided a significant improvement in neurological function and reduced cerebral edema in TBI animals. TBI upregulated NLRP3, apoptosis-associated speck-like adapter protein (ASC), cleaved caspase-1, and interlukein-1β (IL-1β) in the perilesional area. MCC950 efficiently repressed caspase-1 and IL-1β with a transient effect on ASC and NLRP3 post-TBI. MCC950 treatment also provided protection against proapoptotic activation of poly (ADP-ribose) polymerase and caspase-3 associated with TBI. A concurrent inhibition of inflammasome priming was also detectable at the nuclear factor kappa B/p65 and caspase-1 level. Our findings support the implication of NLRP3 inflammasome in the pathogenesis of TBI and further suggests the therapeutic potential of MCC950.
Effect of Cell Culture Conditions on the Anticytomegalovirus Activity of Maribavir (2006)

The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.
Test case generation using Prolog (1985)

For the validation of the kernel system calls of a family of UNIX 1) systems a knowledge based test environment was conceived. A prototype version is currently implemented in Prolog. The knowledge base consists essentially of three parts: test case specifications of the various system calls,a test suite generator with predicates including information about UNIX system properties and sound test practices, anda test protocol archive including utilities to extract and prepare reports about the test results.All information in the knowledge base is stored as Horn clauses, i.e. facts and rules immediately to be consulted and executed by a Prolog interpreter.
Advanced Television Systems (1986)

The United States Advanced Television Systems Committee (ATSC) was formed in 1983 to coordinate the development of national technical standards for advanced television systems and to develop proposed national positions for presentation to the Department of State for purposes of developing United States positions with international organizations.
A chip-based platform for the in vitro generation of tissues in three-dimensional organization (2007)

We describe a multi-purpose platform for the three-dimensional cultivation of tissues. The device is composed of polymer chips featuring a microstructured area of 1-2 cm(2). The chip is constructed either as a grid of micro-containers measuring 120-300 x 300 x 300 microm (h x l x w), or as an array of round recesses (300 microm diameter, 300 microm deep). The micro-containers may be separately equipped with addressable 3D-micro-electrodes, which allow for electrical stimulation of excitable cells and on-site measurements of electrochemically accessible parameters. The system is applicable for the cultivation of high cell densities of up to 8 x 10(6) cells and, because of the rectangular grid layout, allows the automated microscopical analysis of cultivated cells. More than 1000 micro-containers enable the parallel analysis of different parameters under superfusion/perfusion conditions. Using different polymer chips in combination with various types of bioreactors we demonstrated the principal suitability of the chip-based bioreactor for tissue culture applications. Primary and established cell lines have been successfully cultivated and analysed for functional properties. When cells were cultured in non-perfused chips, over time a considerable degree of apoptosis could be observed indicating the need for an active perfusion. The system presented here has also been applied for the differentiation analysis of pluripotent embryonic stem cells and may be suitable for the analysis of the stem cell niche.
<title>Telecentric scanner for 3D profilometry of very large objects</title> (1997)

Triangulation systems that are based on an autosynchronized scanning principle to provide accurate and fast acquisition of 3D shapes are able to scan large fields. It is done generally by a coordinate measuring machine (CMM) carrying a small-volume 3D camera. However the acquisition speed is limited by the CMM movement and also by the image fusion time required to get the complete 3D shape. This paper describes some practical consideration for large volume 3D inspections with emphasis on telecentric scanning. We present the analytical and the optical design of a large telecentric scanner using a large reflective surface. Some results of the laboratory prototype will be presented. We also discuss applications and the viability of this new approach.