gebhart/patrepeval huggingface dataset:
Improvement of Transfection Efficiency in Cultured Chicken Primordial Germ Cells by Percoll Density Gradient Centrifugation (2010)

Chicken primordial germ cells (PGCs) differentiate into germ cells in gonads. Because PGCs can be cloned and cultured maintaining germline competency, they are a good means of modifying the chicken genome, but the efficiency of plasmid transfection into PGCs is very low. In this study, I attempted to improve the efficiency of PGC transfection. Cultured PGCs were purified by Percoll density gradient centrifugation, and were then transfected with plasmid DNA. For transient transfection, the transfection efficiency increased more than 7-fold by the Percoll method. The efficiency of stable transfection of PGCs also increased significantly. The stable transfectants that were isolated by this method accumulated in the developing gonads after microinjection into bloodstream of chick embryos, indicating that gene transfection by Percoll purification did not alter the function of PGCs in vivo.
Studies on the metabolism of propafenone. 1st Comm.: synthesis and chromatographic/mass spectrometric properties of the labelled compound and of the reference substances. (1984)

The synthesis of 14C-propafenone and 2H-propafenone (propafenone: 2-(2'-hydroxy-3'-propylamino-propoxy)-omega-phenyl-propiophenone hydrochloride) and some reference compounds is described. The thin-layer chromatographic, high-performance liquid and gas chromatographic properties of the substances are described. Propafenone and the reference substances were studied by mass spectrometry and compared with each other, with respect to structural elucidation of the metabolites. The chromatographic and mass spectrometric data (key ions) enables the metabolites of propafenone to be identified in biological material.
Challenges in automotive software engineering (2006)

The amount of software in cars grows exponentially. Driving forces of this development are cheaper and more powerful hardware and the demand for innovations by new functions. The rapid increase of software and software based functionality brings various challenges (see [21], [23], [25], [26]) for the automotive industries, for their organization, key competencies, processes, methods, tools, models, product structures, division of work, logistics, maintenance, and long term strategies. From a software engineering perspective, the automotive industry is an ideal and fascinating application domain for advanced techniques. Although the automotive industry may adopt general results and solutions from the software engineering body of knowledge gained in other domains, the specific constraints and domain specific requirements in the automotive industry ask for individual solutions and bring various challenges for automotive software engineering. In cars we find literally all interesting problems and challenging issues of software and systems engineering.
A Quasi-Static Analysis of Open-Ended Coaxial Lines (Short Paper) (1987)

A quasi-static analysis of an open-ended coaxial line terminated by a semi-infinite medium on ground plane is presented in this paper. The analysis is based on a variation formulation of the problem. A comparison of results obtained by this method with the experimental and the other theoretical approaches shows an excellent agreement. This analysis is expected to be helpful in the inverse problem of calculating the permittivity of materials in vivo for a given input impedance of the coaxial line.
Toxicological Profile for Manganese (2012)

This public health statement tells you about manganese and the effects of exposure to it.The Environmental Protection Agency (EPA) identifies the most serious hazardous waste sites in the nation. These sites are then placed on the National Priorities List (NPL) and are targeted for long-term federal clean-up activities. Manganese has been found in at least 869 of the 1,699 current or former NPL sites. Although the total number of NPL sites evaluated for this substance is not known, the possibility exists that the number of sites at which manganese is found may increase in the future as more sites are evaluated. This information is important because these sites may be sources of exposure and exposure to this substance may harm you.When a substance is released either from a large area, such as an industrial plant, or from a container, such as a drum or bottle, it enters the environment. Such a release does not always lead to exposure. You can be exposed to a substance only when you come in contact with it. You may be exposed by breathing, eating, or drinking the substance, or by skin contact.If you are exposed to manganese, many factors will determine whether you will be harmed. These factors include the dose (how much), the duration (how long), and how you come in contact with it. You must also consider any other chemicals you are exposed to and your age, sex, diet, family traits, lifestyle, and state of health.
Physical and chemical stability of palonosetron hydrochloride with five common parenteral drugs during simulated Y-site administration (2008)

Palonosetron hydrochloride is physically and chemically stable with atropine sulfate, famotidine, heparin sodium, lidocaine hydrochloride, and potassium chloride during simulated Y-site administration.
PAPR reduction technique for optical SSB modulation using peak folding (2015)

PAPR of optical SSB modulated signal was reduced by folding peaks using transfer function of LN modulator. The minimum PAPR of 1.52 and 3 dB improvement of SPM threshold were achieved.
Imaging in 3-D DMO; Part II, Amplitude effects (1997)

Abstract The amplitude of the dip-moveout (DMO) output for a planar reflector at a point P and half offset k is a function of the curvature of the midpoint curve of the DMO input traces, the dip magnitude, and the dip direction. No single weighting function will preserve the amplitude of dipping events. Seismic synthetics on a circle of midpoints minimal data set verify that this data set has 6 dB of amplitude variation with azimuth for a 15 degrees dipping reflector and a 14 dB variation for a 45 degrees reflector. The theory shows that the 3DDMO weight for an arbitrary minimal data set is equal to the impulse response weight multiplied by the density of the normal segments at the dip being imaged. Aliasing is also a function of the normal segment density at the dip being imaged. If the spatial sampling is fine enough to prevent aliasing, DMO can be performed on a dip by dip basis and, by correcting for the normal segment density, these amplitude variations may be corrected.
Combination Treatment With Varenicline and Bupropion in an Adaptive Smoking Cessation Paradigm (2014)

Among smokers who did not show a sufficient initial response to prequit nicotine patch treatment, combination treatment with varenicline and bupropion proved more efficacious than varenicline alone for male smokers and for smokers with a high degree of nicotine dependence.
A timing-driven global router for custom chip design (2002)

A timing-driven global router is presented for custom chip design, whose objective is maximizing the minimum delay slack. Resistances and capacitances of interconnections, input gate capacitances and output driver resistance are used to approximate the interconnection delays during the routing. The router incrementally updates the delay at each sink pin of the signal obtained from the previous step during the routing. The maximum allowable delay at each sink pin (from a timing analyzer) along with the computed interconnection delays is used to guide the search process for the maximum-delay-slack route. It is shown that when the interconnection resistance is comparable to the output-driver resistance, minimizing the total net length is not always equivalent to minimizing the delay for a multiterminal net. The algorithm presented is experimentally shown to produce global routes achieving the objective.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Note On Leaning Indicators Of Housing Market Price Trends (1986)

Most indicators of changing housing demand and supply provide signals for longer term trends. Many market participants such as mortgage lenders, speculators, real estate brokers, developers, and appraisers, would benefit if short term price trends could be better monitored and predicted. This research builds upon several simple and straightforward statistical indicators of housing market price movements to analyze either local, regional or national trends. It utilizes existing housing resale data as well as new housing market data.
Vancomycin-resistant gram-positive bacteria isolated from human sources (1988)

Recent reports of infections with vancomycin-resistant gram-positive bacteria prompted us to study vancomycin-resistant isolates from human sources to characterize the types of bacteria displaying this phenotype. Thirty-six vancomycin-resistant gram-positive isolates, 14 from clinical specimens and 22 from stool samples, were identified. These isolates were tentatively identified as Lactobacillus spp. (25 strains), Leuconostoc spp. (6 strains), and Pediococcus spp. (3 strains) on the basis of morphology and physiological tests. Two isolates of indeterminate morphology could not be unambiguously assigned to a genus. Four isolates of vancomycin-resistant lactobacilli from normally sterile body sites were considered to be clinically significant. Vancomycin-resistant gram-positive bacteria may represent an emerging class of nosocomial pathogens. Better methods for distinguishing the various genera in the clinical microbiology laboratory are needed.
Common Evolute Element (CEE) stack and imaging (zero‐offset stack) (1990)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1990Common Evolute Element (CEE) stack and imaging (zero‐offset stack)Authors: S. KeydarB. GelchinskyV. ShtivelmanA. BerkovitchS. KeydarInstitute for Petroleum Research and Geophysics (IPRG), Israel, B. GelchinskyTel Aviv University (TAU), V. ShtivelmanIPRG, and A. BerkovitchTAUhttps://doi.org/10.1190/1.1890107 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1890107FiguresReferencesRelatedDetailsCited byCurvatures and inhomogeneities: An improved common-reflection-surface approachBenjamin Schwarz, Claudia Vanelle, Dirk Gajewski, and Boris Kashtan21 August 2014 | GEOPHYSICS, Vol. 79, No. 5Homeomorphic imaging approach — theory and practiceJournal of Applied Geophysics, Vol. 42, No. 3-4Multifocusing homeomorphic imagingJournal of Applied Geophysics, Vol. 42, No. 3-4Multifocusing homeomorphic imagingJournal of Applied Geophysics, Vol. 42, No. 3-4Seismics and optics: hyperbolae and curvaturesJournal of Applied Geophysics, Vol. 42, No. 3-4Common-reflection-surface stack — a real data exampleJournal of Applied Geophysics, Vol. 42, No. 3-4 SEG Technical Program Expanded Abstracts 1990ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1990 Pages: 1779 publication data© 1990 Copyright © 1990 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION S. Keydar, B. Gelchinsky, V. Shtivelman, and A. Berkovitch, (1990), "Common Evolute Element (CEE) stack and imaging (zero‐offset stack)," SEG Technical Program Expanded Abstracts : 1719-1722. https://doi.org/10.1190/1.1890107 Plain-Language Summary PDF DownloadLoading ...
A Risk-reduction Argument for Planning (2007)

The article emphasizes the importance of planning which helps to reduce risk to a reasonable level especially during natural hazards. The training provided by Emergency Management Australia in planning for risk is also discussed.
Design of error detection scheme for class C service in ATM (1994)

Presents a logical approach to designing an effective and efficient error detection scheme for ATM. The authors specifically look at providing error protection for the class C service of ATM, which is a connection oriented, variable bit rate service, with no required timing between source and destination. The resulting scheme is similar to the scheme proposed by the CCITT in AAL 5. The authors propose to add a 34 bit CRC to each frame. Their proposal also includes a modification of the mechanism for preventing misdirected cells that is used at the ATM layer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Cumulative Index of the Canadian Journal of Political Science/Index des articles parus dans la Revue canadienne de science politique (1969)

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Identification of Receptor-Binding Pharmacophores of Growth-Hormone-Releasing Factor in Rat Adenopituitary (1994)

Previous structure-activity studies on growth-hormone-releasing factor (GRF) have mainly been carried out in pituitary cell culture assays. In such systems, the molecular features necessary to increase GRF receptor affinity cannot be fully distinguished from those that improve proteolytic resistance. To assess the affinity of GRF analogues, we have recently characterized [125I-Tyr10]hGRF(1-44)NH2 binding to rat adenopituitary, developing a reliable binding assay in which GRF-carboxamide-related peptides are stable. In the present study, we have determined the binding affinity of two series of analogues in which the entire sequence of hGRF(1-29)NH2 was scanned with D-amino acid and alanine substitutions. To further document their potency, we have evaluated the ability of representative candidates of each series to stimulate cAMP production. In the first series, a D-amino acid substitution at Ala4, Ile5, Phe6, Thr7, Val13, Gln16, Leu17, Ala19, Arg20 and Ile26 decreased drastically the binding affinity of hGRF(1-29)NH2 while it induced a smaller decrease at Tyr1, Asp3, Ser9, Tyr10, Arg11, Lys12, Leu14, Ala15, Ser18, Lys21, Leu22, Leu23, Gln24, Met27 and Ser28. Interestingly, a D-substitution in position 8 generated an analogue exhibiting a significantly greater binding affinity than hGRF(1-29)NH2, while it had no influence on hGRF(1-29)NH2 affinity at Ala2, Asp25 and Arg29. Adenylate cyclase activities of [D-Tyr1], [D-Tyr10] and [D-Arg20]hGRF(1-29)NH2 correlate with their binding affinity. In the second series, the largest decrease of binding affinity was observed with an alanine substitution at Tyr1, Asp3, Ile5, Phe6, Tyr10, Arg11, Lys12, Leu14, Leu17, Arg20 and Lys21.(ABSTRACT TRUNCATED AT 250 WORDS)
Cocaine Stimulates the Human Cardiovascular System via a Central Mechanism of Action (1999)

These studies provide direct microneurographic evidence in humans that intranasal cocaine stimulates central sympathetic outflow. This central sympathetic activation appears to be targeted not only to the cutaneous circulation promoting peripheral vasoconstriction but also to the heart promoting tachycardia.
Irritable Bowel Syndrome Is Positively Related to Metabolic Syndrome: A Population-Based Cross-Sectional Study (2014)

Irritable bowel syndrome is a common gastrointestinal disorder that may affect dietary pattern, food digestion, and nutrient absorption. The nutrition-related factors are closely related to metabolic syndrome, implying that irritable bowel syndrome may be a potential risk factor for metabolic syndrome. However, few epidemiological studies are available which are related to this potential link. The purpose of this study is to determine whether irritable bowel syndrome is related to metabolic syndrome among middle-aged people. We designed a cross-sectional study of 1,096 subjects to evaluate the relationship between irritable bowel syndrome and metabolic syndrome and its components. Diagnosis of irritable bowel syndrome was based on the Japanese version of the Rome III Questionnaire. Metabolic syndrome was defined according to the criteria of the American Heart Association scientific statements of 2009. Dietary consumption was assessed via a validated food frequency questionnaire. Principal-components analysis was used to derive 3 major dietary patterns: "Japanese", "sweets-fruits", and "Izakaya (Japanese Pub) "from 39 food groups. The prevalence of irritable bowel syndrome and metabolic syndrome were 19.4% and 14.6%, respectively. No significant relationship was found between the dietary pattern factor score tertiles and irritable bowel syndrome. After adjustment for potential confounders (including dietary pattern), the odds ratio (95% confidence interval) of having metabolic syndrome and elevated triglycerides for subjects with irritable bowel syndrome as compared with non-irritable bowel syndrome are 2.01(1.13-3.55) and 1.50(1.03-2.18), respectively. Irritable bowel syndrome is significantly related to metabolic syndrome and it components. This study is the first to show that irritable bowel syndrome was significantly related to a higher prevalence of metabolic syndrome and elevated triglycerides among an adult population. The findings suggest that the treatment of irritable bowel syndrome may be a potentially beneficial factor for the prevention of metabolic syndrome. Further study is needed to clarify this association.
Logical concepts in cryptography (2007)

This thesis is about a breadth-first exploration of logical concepts in cryptography and their linguistic abstraction and model-theoretic combination in a comprehensive logical system, called CPL (for Cryptographic Protocol Logic). We focus on two fundamental aspects of cryptography. Namely, the security of communication (as opposed to security of storage) and cryptographic protocols (as opposed to cryptographic operators). The primary logical concepts explored are the following: the modal concepts of belief, knowledge, norms, provability, space, and time. The distinguishing feature of CPL is that it unifies and refines a variety of existing approaches. This feature is the result of our wholistic conception of property-based (modal logics) and model-based (process algebra) formalisms.
NANDFlashSim: Intrinsic latency variation aware NAND flash memory system modeling and simulation at microarchitecture level (2012)

As NAND flash memory becomes popular in diverse areas ranging from embedded systems to high performance computing, exposing and understanding flash memory's performance, energy consumption, and reliability becomes increasingly important. Moreover, with an increasing trend towards multiple-die, multiple-plane architectures and high speed interfaces, high performance NAND flash memory systems are expected to continue to scale. This scaling should further reduce costs and thereby widen proliferation of devices based on the technology. However, when designing NAND flash-based devices, making decisions about the optimal system configuration is non-trivial because NAND flash is sensitive to a large number of parameters, and some parameters exhibit significant latency variations. Such parameters include varying architectures such as multi-die and multi-plane, and a host of factors that affect performance, energy consumption, diverse node technology, and reliability. Unfortunately, there are no public domain tools for high-fidelity, microarchitecture level NAND flash memory simulation in existence to assist with making such decisions. Therefore, we introduce NANDFlashSim; a latency variation-aware, detailed, and highly configurable NAND flash simulation model. NANDFlashSim implements a detailed timing model for operations in sixteen state-of-the-art NAND flash operation mode combinations. In addition, NANDFlashSim models energies and reliability of NAND flash memory based on statistics. From our comprehensive experiments using NANDFlashSim, we found that 1) most read cases were unable to leverage the highly-parallel internal architecture of NAND flash regardless of the NAND flash operation mode, 2) the main source of this performance bottleneck is I/O bus activity, not NAND flash activity itself, 3) multi-level-cell NAND flash provides lower I/O bus resource contention than single-level-cell NAND flash, but the resource contention becomes a serious problem as the number of die increases, and 4) preference to employ many dies rather than to employ many planes promises better performance in disk-friendly real workloads. The simulator can be downloaded from http://www.cse.psu.edu/~mqj5086/nfs.
Thermal inertia contrast detection of subsurface structures (2009)

A novel dual-band infrared computed tomography method is described. It applies thermal inertia imaging to detect temporal heat flows from naturally-heated underground or faulty structures. The added values over earlier methods are the use of a temperature simulation model and clutter removal algorithms. They save time, clarify interpretation and specify the subsurface object location, orientation, depth, height (or thickness) and volume. Previous methods incorporated in the methodology successfully viewed a 6-60 m deep aquifer, a 1/10 m<sup>3</sup> bridge-deck rut and a 1-15 m deep rock-covered drain. Temporal heat flows were viewed from mobile platforms 3 m to 3 km above ground. Emissivity-corrected thermal survey data agreed with 1-2 m deep thermal-probe and 6-60 m deep thermal-gradient data.
IEEE 802.11 Distance Estimation Based on RTS/CTS Two-Frame Exchange Mechanism (2009)

The addition of positioning capabilities to widespread communications such as IEEE 802.11 compliant networks could open up interesting markets, in particular if a low-cost hardware has to be added to the existing one and standard RTS/CTS control frames exchange could be used for this purpose. In this paper various statistical estimators of the delay profile observed, derived from Round-Trip Time measurements, are analyzed and a linear regression of the statistical estimators is applied in order to improve the accuracy of distance estimation between a Mobile User and an Access Point. A precision in distance estimation with errors in the range of a meter is achieved.
Patterning process for semiconductor using directed self assembly (2013)

Directed self-assembly (DSA) process of block copolymers (BCPs) has been considered as a candidate for sub-20nm contact patterning. In recent years the semiconductor manufacturers have been interested in use DSA in production. DSA is based on the intrinsic property of the BCPs which is phase-separation in the molecular scale, but significant problems remain for device application. Process time, high process temperature, defect, and CD distribution make the using of DSA difficult in mass production. One of the most considered problems for DSA is the CD Distribution. A guide material for grapho-epitaxy DSA process requires resistance against high temperature and solvent. We use negative tone develop (NTD) photoresist (PR) guide for simple process and thermal resistance, and additional treatment for resistance against high temperature and solvent. The CD distribution of DSA is highly related to the phase separation itself. In order to get better performance, the polymer chains should have sufficient mobility under heating above their glass temperature. Therefore, film thickness and molecular weight of BCPs are very important parameters for CD distribution of DSA process. From the results, it is proven that guide materials, film thickness of BCPs, and molecular weight of BCPs are significant parameter in order to improve CD distribution of DSA patterns.