gebhart/patrepeval huggingface dataset:
A phase 1 trial of PT-100 in patients receiving myelosuppressive chemotherapy (2004)

2572 Background: PT-100 is a small molecule which competitively inhibits dipeptidyl peptidase activity of fibroblast activation protein (FAP) and dipeptidyl peptidase IV (DPP-IV). It rapidly increases cytokine (G-CSF, IL-8) production, accelerates neutrophil and erythrocyte regeneration, and causes tumor regression in mice via inhibition of FAP and DPP-IV. This dose-escalation study was conducted to evaluate the safety of PT-100 in patients receiving myelosuppressive chemotherapy (a doxorubicin or taxane based regimen) and to assess its effects on neutrophil recovery. Methods: Patients received 2 cycles of chemotherapy: the first cycle (C1) served as each patient's individual control. PT-100 was administered orally for 7 days in cycle 2 (C2) as a 200, 400, 800, and 1200mcg total daily dose (divided twice daily) to 6, 6, 13, and 4 patients, respectively. Most patients received PT-100 on Days 2–8 of chemotherapy in C2, except at 800mcg where one cohort was treated on a Day 5–11 schedule. Patients had to have Grade 3/4 neutropenia in C1 to receive PT-100 in C2. Results: Five of 13 patients receiving PT-100 800mcg experienced a ≥ 2-day improvement in ≥ Grade 3 neutropenia, and a 62% improvement in median AUC in C2 vs. C1 was observed in patients treated on the Day 2–8 schedule. A corresponding upregulation in G-CSF, IL-6, and IL-8 was observed in most patients. Overall, PT-100 was well-tolerated. Edema/peripheral swelling, hypotension, and hypovolemia were the most common non-hematologic AEs considered related to PT-100. Two Grade 3 AEs were considered related to PT-100: syncope (1200mcg) and orthostatic hypotension (800mcg). An MTD was not reached. Conclusions: Given the accelerated neutrophil recovery, strong preclinical evidence of antitumor activity, and tolerable toxicities of PT-100, studies using a longer PT-100 dosing schedule are warranted to investigate its antitumor and neutrostatic effects. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Point Therapeutics Point Therapeutics Point Therapeutics Cell Genesys; ONYX Pharmaceuticals Corixa
Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia (2013)

Recent evidence suggests that inhibition of bromodomain and extra-terminal (BET) epigenetic readers may have clinical utility against acute myeloid leukemia (AML). Here we validate this hypothesis, demonstrating the efficacy of the BET inhibitor I-BET151 across a variety of AML subtypes driven by disparate mutations. We demonstrate that a common 'core' transcriptional program, which is HOX gene independent, is downregulated in AML and underlies sensitivity to I-BET treatment. This program is enriched for genes that contain 'super-enhancers', recently described regulatory elements postulated to control key oncogenic driver genes. Moreover, our program can independently classify AML patients into distinct cytogenetic and molecular subgroups, suggesting that it contains biomarkers of sensitivity and response. We focus AML with mutations of the Nucleophosmin gene (NPM1) and show evidence to suggest that wild-type NPM1 has an inhibitory influence on BRD4 that is relieved upon NPM1c mutation and cytosplasmic dislocation. This leads to the upregulation of the core transcriptional program facilitating leukemia development. This program is abrogated by I-BET therapy and by nuclear restoration of NPM1. Finally, we demonstrate the efficacy of I-BET151 in a unique murine model and in primary patient samples of NPM1c AML. Taken together, our data support the use of BET inhibitors in clinical trials in AML.
The Testing and Evaluating System for the Security Operating System Based on the Mechanism of Keyword-Driven (2009)

Comparing with the common operating system, the secure operating system can provide the user with a more safe and reliable operating platform of the computer system. The testing to the security functions of the secure operating system has become the important measure to verify its security. On the basis of the standard on the evaluation of the security of the information technology made by China (GB/T18336-2001), this paper presents the evaluating system to the secure operating system. The evaluating system uses the keyword-driven mechanism and realizes the better automatic testing and evaluating of the operating system.
Nonuniform Current Distribution and Thickness during Electrodeposition onto Resistive Substrates (1992)

The interaction of electrode and electrolyte resistances during plating onto resistive substrates is investigated. Following presentation of an asymptotic treatment for the estimation of current distributions on highly resistive substrates, more general cases are examined by numerical calculation to illustrate the influence of counterelectrode position, Tafel kinetics, and mass‐transfer limitations. The calculations are compared with approximate models presented in the literature or developed in this study in order to determine under which conditions they are applicable. The temporal evolution of the current distribution and conductance during deposit growth is investigated, and an approximate method for the determination of the variation in deposit thickness with time is presented.
On multiprogramming, machine coding, and computer organization (1969)

The author feels that the interrupt feature which is available in most modern computers is a potent source of programming pitfalls and errors, and that it therefore may heavily contribute to the unreliability of programs making use of it. A programming scheme is presented which avoids the concept of the interrupt and permits the specification of concurrent (or pseudoconcurrent) activities in a supposedly more perspicuous manner. It is intended to serve as a basis for the construction of operating systems, which are prime examples of programs with concurrent activities. The scheme includes a set of basic instructions for the generation, termination, and synchronization of parallel processes. A set of routines representing these instructions and thereby simulating a hypothetical machine organization has been implemented and tested on the IBM System/360. Two programs using these instructions, written in PL360, are presented.
Carrying the torch for integrated working (2002)

Working in an integrated health and social care trust has convinced Ben Thomas that pooling resources can improve services and foster innovation
Advanced Wound-care Materials: Ultra High Absorbing Fibres made from Alginates Containing Branan Ferulate and Carboxymethyl Cellulose (2004)

Abstract Abstract The effects of spinning bath components and calcium chloride concentration on tensile and absorption properties of alginate fibres containing 25% w/w branan ferulate has been reported in an earlier paper, (Miraftab et al., 2000). The study concluded that a 1% w/v concentration of calcium chloride provides the optimum condition for achieving suitably strong fibres with adequate absorption capacity whilst allowing only the minimum of branan ferulate loss during wash and post production treatments. In this paper the effects of introducing a third component, sodium carboxymethyl cellulose (NaCMC, Blanose¯ 7HF), on overall tensile and absorbency of these new fibres (ABC) are reported. In a comparison of their absorbency with that of commercially available fibres of similar calibre, it was shown that 10% w/w NaCMC inclusion improves fibre wet strength and thus structural integrity of potential wound dressings. Furthermore, the new fibres show a significant increase in both saline and Solution A uptake compared to the commercial fibres. Analytical investigations have shown that Aquacel¯ wound dressing fibres (made by ConvaTec) contain a CMC type material which is essentially identical in terms of chemical functionality to Blanose¯ 7HF sodium carboxymethyl cellulose (made by Hercules Aqualon). The degree of substitution (in terms of carboxymethylation) in Blanose 7HF used in ABC fibres is shown to be approximately twice that of Aquacel. ABC fibres are therefore offered as a viable alternative to existing materials. Keywords: Alginatebranan ferulatecarboxymethyl cellulose (CMC)tenacitySolution A
Facile route fabrication of nickel based mesoporous carbons with high catalytic performance towards 4-nitrophenol reduction (2014)

Novel nickel based mesoporous carbons are firstly in situ fabricated via pyrolysis of CTAB-chitosan-nickel supramolecular aggregates, which are pre-constructed by CTAB-directed self-assembly of 8-quinolinol modified chitosan and nickel acetate under basic conditions. This facile route fabrication method renders smart and homogeneously dispersed Ni nanoparticles (NPs) on the mesoporous carbonaceous framework without using any stabilizer and additional reductant, verified by high-energy X-ray diffraction, TEM, X-ray absorption fine structure, N2 adsorption/desorption and Raman spectroscopy. Moreover, it is found that the morphology of Ni NPs, the textural property of carbonaceous supports, and the corresponding catalytic performance towards 4-nitrophenol reduction vary with the pyrolysis temperature. It is suggested that the nickel based mesoporous carbon pyrolyzed at 750 °C (Ni/MC-750) simultaneously possessing uniform spherical Ni NPs (24.5 nm) and bottle-neck mesopores exhibits the largest activity factor of 20.9 s−1 g−1 of any nickel catalysts.
Selection of eutectic systems in AI<sub>2</sub>O<sub>3</sub>–Y<sub>2</sub>O<sub>3</sub> ceramics (2001)

There are two eutectic reactions in the Al203–rich portion of the AI2O3-Y2O3 pseudo–binary system; one is the equilibrium A1203–YAG eutectic reaction at 1826%C, and the other is the metastable A1203–YAP eutectic reaction at 1702%C. Selection of the A1203–YAG and the A1203–YAP eutectics was examined in terms of cooling rate, nucleation temperature and maximum melt temperature. When the melt was cooled from 2100%C at any cooling rate, it always nucleated below the Al203–YAP eutectic temperature, therefore the Al203–YAP eutectic was selected. The Al203–YAG eutectic was selected when the melt was cooled from 1900%C at a cooling rate of less than 1 K s-1. The selection of the two eutectic systems was determined by the nucleation temperature, although the maximum holding temperature of the melt and the cooling rate significantly affected the nucleation temperature. The structure of the melt, such as coordination of oxygen and chemical order when being heated to 2100%C may affect the nucleation behavior.
Digital Beamforming Synthetic Aperture Radar (DBSAR) Polarimetric Upgrade (2011)

The Digital Beamforming Synthetic Aperture Radar (DBSAR) is a state-of-the-art radar system developed at NASA/Goddard Space Flight Center for the development and implementation of digital beamforming radar techniques. DBSAR was recently upgraded to polarimetric operation in order to enhance its capability as a science instrument. Two polarimetric approaches were carried out which will be demonstrated in upcoming flight campaigns.
Logic synthesis of race-free asynchronous CMOS circuits (1991)

A synthesis method for generating race-free asynchronous CMOS circuits that are independent of the internal and output delays is presented. The design method is based on the properties of the negative gates. An inertial delay is associated with each negative gate in a CMOS circuit. Such a gate model is quite realistic. The basic principle of the method presented is to augment and to modify the original flow table in such a way that the obtained logic diagram contains only negative gates. In addition, the synthesis method is capable of avoiding any race, and consequently any critical race or hazard. The method minimizes the number of internal variables and therefore the number of gates, providing new simple cells for fast and low-power integrated circuits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Cyst-forming Coccidia: Toxoplasma, Neospora, Sarcocystis]. (1995)

The most important cyst-forming coccidian parasites in human and veterinary medicine belong the genera of Toxoplasma, Neospora and Sarcocystis. Toxoplasma gondii shows its clinical relevance in congenital infections and opportunistic infections in immunodeficient patients. In veterinary medicine the parasite is predominantly the cause of important economic loss in livestock production. Neospora causes diseases resembling toxoplasmosis; neosporosis is one of the most important causes of bovine abortion in the US. Neospora caninum leads to myositis and paralysis in dogs. The potential implication of Neospora in toxoplasmosis-like diseases in humans is not yet known. Sarcocystis is usually a relatively harmless intestinal parasite in humans. Recent data from tropical areas suggest that man can also become an intermediate host for certain Sarcocystis species, which potentially represents a source of opportunistic infection and disease in areas with increasing HIV prevalence. In veterinary medicine, Sarcocystis causes muscle diseases and also abortion or myeloencephalitis with lethal outcome in certain animal species. Molecular-epidemiological investigations have resulted in a new understanding of biological and population-genetic mechanisms relevant to the disease. Recently developed molecular techniques, such as transfection in protozoan parasites, are presently used not only to elucidate molecular-pathogenetic events in the course of disease, but also to prepare potential new immuno-therapeutic tools for future vaccination against infection or disease.
Mycobacterium tuberculosis Infection Is Associated with the Development of Erythema Nodosum and Nodular Vasculitis (2013)

Our data strongly suggest that MTB infection and active TB are associated with the development of NV and EN in Chinese.
Receptor-Mediated Actions of Growth Hormone Releasing Factor on Granulosa Cell Differentiation (1990)

GRF promotes follicular maturation and ovulation when administered with FSH in the treatment of infertility. Such actions could be mediated by stimulation of GH secretion and insulin-like growth factor I production, but the known actions of the structurally related hormone, vasoactive intestinal peptide (VIP), on granulosa cell function suggested that GRF may also act directly on the ovary to stimulate follicular development. Radioligand binding and activation studies, performed in granulosa cells from immature estrogen-treated rats, revealed a common receptor for VIP and rat (r) GRF in the ovary. Specific binding of [125I]VIP to granulosa cells was saturable and dependent on time and temperature. The relative potencies of VIP-related peptides for inhibition of radioligand binding were: VIP greater than rGRF greater than peptide histidine isoleucinamide greater than [His1,Nle27] human GRF(1-32)NH2 greater than secretin. In binding studies with the potent GRF agonist, [125I] [His1,Nle27]GRF(1-32)NH2, relative potencies were: rGRF(1-43)OH greater than [His1,Nle27]human GRF(1-32)NH2 greater than VIP greater than peptide histidine isoleucinamide greater than secretin. Glucagon and gastric inhibitory peptide, other peptides of the glucagon superfamily, and unrelated peptides including CRF and beta-endorphin, did not inhibit binding of either radioligand to ovarian receptors. In cultured granulosa cells, rGRF and VIP stimulated cAMP formation, consistent with coupling of their receptors to the adenylate cyclase system, and potentiated FSH-induced cAMP production. Both peptides also amplified FSH-induced progesterone biosynthesis, aromatase activity, and LH receptor formation. These observations demonstrate that rGRF is a potent cAMP-mediated agonist in the rat ovary and acts on a common VIP/GRF receptor in maturing granulosa cells. It is likely that the potentiating effect of administered GRF on gonadotropin-stimulated follicular development in vivo is in part mediated by direct actions of the peptide on the VIP/GRF receptor. Also, since GRF is present in the gonads, it is possible that the locally-produced peptide promotes follicular maturation by paracrine modulation of the stimulatory action of FSH on granulosa cell function.
A run-to-run film thickness control of chemical-mechanical planarization processes (2005)

With the continuing shrink of device geometries, tightly control of semiconductor manufacturing processes becomes a critical factor to improve the process performance, throughput and yield. In this paper, we present design, analysis and implementation of a run-to-run film thickness control scheme for chemical-mechanical planarization (CMP) processes. A predictor-corrector type of control law is utilized to regulate the CMP process time. The control algorithm uses the information of the monitor wafer removal rate and the consumable lifetime to compensate for process drifts and shifts. We also discuss a compensation method for CMP polisher head-to-head variations. The process results in a production fab show a significant improvement of CMP performance under the proposed control scheme.
Ovarian hyperstimulation syndrome: classifications and critical analysis of preventive measures (2003)

The aim of this review was to summarize previously published classifications for ovarian hyperstimulation syndrome (OHSS), as well as to analyse the available methods for preventing OHSS. Withholding hCG and cycle cancellation--once the main methods of preventing OHSS--are now seldom used. There is a growing body of evidence to support the use of coasting to prevent OHSS, without cycle cancellation. However, most studies on coasting are retrospective, and well-designed prospective randomized studies are lacking. There is no current consensus as to how coasting should be carried out. A serum estradiol level of 3000 pg/ml is generally considered optimum for administration of hCG. It appears that intravenous albumin or hydroxyethyl starch at the time of oocyte retrieval is beneficial in preventing OHSS, but does not offer complete protection. There is insufficient evidence to support routine cryopreservation of all embryos for the later transfer of frozen-thawed embryos in high-risk patients. Several uncontrolled studies have reported the protective effect of GnRH agonist to trigger ovulation in preventing OHSS, though the method is applicable solely for gonadotrophin-only or GnRH antagonist cycles. A single dose of recombinant LH to trigger ovulation significantly reduced OHSS as compared with hCG. The possible role of GnRH antagonist protocols in reducing the incidence of OHSS is debatable. The above measures to prevent OHSS were successful in reducing the incidence of the syndrome, but complete prevention is not as yet possible.
Fabrication and structural characterization of a resonant frequency PZT microcantilever (2001)

The fabrication and structural characterization of a surface micromachined, resonant frequency, Pb(Zr, Ti)O3 (PZT) microcantilever will be presented. The PZT microcantilever was fabricated using surface micromachining techniques, and used a low-stress silicon nitride thin film as the base material for the microcantilever onto which a PZT thin film was incorporated. The PZT thin film is used as both the microsensor and the microactuator. A unique fabrication procedure was developed in order to eliminate the step of encapsulating the PZT during the removal of the spacer layer. The encapsulation step was avoided because of the difficulty in finding a suitable material, which would protect the PZT during the removal of the spacer layer yet not affect its material properties. This predicament was resolved by removing the spacer layer prior to the deposition of the PZT. The microcantilevers were characterized extensively using an atomic force microscope in an unusual manner. The atomic force microscope was modified in such a fashion that the deflection at the tip of the microcantilever could be measured as the frequency of an electrical signal applied to the PZT thin film was varied. In addition, an impedance analyzer was used to characterize the microcantilevers. Simple thin-film, laminated plate theory was used to obtain a closed-form solution for the modal response of the microcantilever, while ANSYS was used to obtain modal and harmonic simulation results. It will be shown that the experimental, numerical, and theoretical modal results are within ±10% of one another. The experimental and numerical harmonic results differ by an order of magnitude; however, the numerical model is currently being modified to more accurately represent the PZT microcantilever. From the information gathered during the structural characterization of the PZT microcantilever, it will be shown that certain higher-order resonant frequency modes have very large mechanical responses. These higher-order resonant frequency modes give designers another parameter to adjust when trying to optimize the design of their resonant frequency device.
FID: A Faster Image Distribution System for Docker Platform (2017)

Docker has been widely adopted in enterprise-level container environment. As an important part of Docker-based container ecosystem, Docker Registry provides the service of storing, distributing and managing Docker images, which is crucial to run Docker containers. In large-scale container platforms, deploying applications is prone to overburdening Docker Registry with flooding network traffic, and this situation may even cause failures of image services. In this paper, we present a new P2P-based large-scale image distribution system called FID (Faster Image Distribution), which is able to accelerate the speed of distributing Docker images by taking full advantage of the bandwidth of not only Docker Registry but also other nodes in the cluster. We implemented and validated FID on the enterprise-level cluster. The experiment results show that, compared to the native image distribution method, FID reduces at least 97% of network traffic for Docker Registry. Furthermore, it reduces 83.50% of distribution time on average when distributing images among 200 nodes, and particularly, reduces up to 91.35% of distribution time for the 500M image of Hadoop.
Depth Profile of Uncompensated Spins in an Exchange Bias System (2005)

We have used the unique spatial sensitivity of polarized neutron and soft x-ray beams in reflection geometry to measure the depth dependence of magnetization across the interface between a ferromagnet and an antiferromagnet. The net uncompensated magnetization near the interface responds to applied field, while uncompensated spins in the antiferromagnet bulk are pinned, thus providing a means to establish exchange bias.
Continued Development of an Ultra-Narrow Bandpass Filter for Solar Research (1993)

The objective of work under this task was to develop ultranarrow optical bandpass filters and related technology necessary for construction of a compact solar telescope capable of operating unattended in space. The scientific problems to which such a telescope could be applied include solar seismology, solar activity monitoring, solar irradiance variations, solar magnetic field evolution, and the location of targets for narrow-field specialized telescopes. We have demonstrated a Y-cut lithium-niobate Fabry-Perot etalon. This filter will be used on the Flare Genesis Experiment. We also obtained solar images with a Z-cut etalon. The technical report on etalon filters is attached to this final report. We believe that work under this grant will lead to the commercial availability of a universal optical filter with approximately 0.1 A bandwidth. Progress was made toward making a suitable 1-2 A tunable blocker filter, but it now appears that the best approach is to make a double-cavity etalon that will not require such a narrow blocker. Broader band blockers are commercially available.