gebhart/patrepeval huggingface dataset:
Detection of coded modulation signals on linear, severely distorted channels using decision-feedback noise prediction with interleaving (1988)

On linear bandlimited Gaussian noise channels with sufficiently high SNR, channel capacity can be approached by combining powerful coded modulation schemes designed for Nyquist channels with the equalization power of decision-feedback equalization (DFE). However, this combination may not be realized in a straightforward manner, since, in general, DFE requires delay-free decisions for feedback, and in a coded system such decisions are not sufficiently reliable. A technique is proposed that combines periodic interleaving with noise-predictive DFE, so that delayed reliable decisions can be used for feedback. When sufficient delay in the interleavers can be tolerated, this technique can attain the DFE performance. On severely distorted channels, modest delays can be sufficient to obtain respectable gains over linear equalization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ChemInform Abstract: A CONVENIENT, LARGE‐SCALE PREPARATION OF 2‐ACETAMIDOACRYLIC ACID AND ITS METHYL ESTER (1977)

Abstract N‐Acyl‐alaninmethylester (I) werden mit tert.‐Butylhypochlorit (II) in Methanol in die N‐Chlor‐Derivate (III) übergeführt, deren Behandlung mit tert. Aminen wie DABCO, DBU oder Triäthylamin zu einem Gemisch aus N‐Acyl‐acrylsäuremethylester (IV) und Ausgangsmaterial (I) führt.
Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. (1979)

The ability of microsomal membranes to translocate nascent presecretory proteins across their lipid bilayer into the intravesicular space was investigated by using trypsin as a proteolytic probe. We found that under defined conditions trypsin is able to dissect the translocation activity of microsomal membranes into components that can be separated into two fractions, one soluble and the other membrane bound. The trypsinized membrane fraction has lost its translocation activity. Addition of the trypsin-generated soluble fraction, however, results in reconstitution of translocation activity. These results are compatible with the notion proposed in the signal hypothesis that the translocation activity of the microsomal membrane resides in transmembrane protein(s). We propose that trypsin effects solubilization from the membrane of cytosol-exposed domain(s) involved in recognition of the signal sequence or ribosome or both, leaving behind membrane-integrated domain(s) that provide the environment for the passage of the nascent chain across the membrane. Signal peptidase activity was unaffected by trypsinization of microsomal vesicles consistent with a localization of the active site of this enzyme on the cisternal side of the vesicles.
AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism (2010)

Alzheimer disease is an age-related neurodegenerative disorder characterized by amyloid-beta (Abeta) peptide deposition into cerebral amyloid plaques. The natural polyphenol resveratrol promotes anti-aging pathways via the activation of several metabolic sensors, including the AMP-activated protein kinase (AMPK). Resveratrol also lowers Abeta levels in cell lines; however, the underlying mechanism responsible for this effect is largely unknown. Moreover, the bioavailability of resveratrol in the brain remains uncertain. Here we show that AMPK signaling controls Abeta metabolism and mediates the anti-amyloidogenic effect of resveratrol in non-neuronal and neuronal cells, including in mouse primary neurons. Resveratrol increased cytosolic calcium levels and promoted AMPK activation by the calcium/calmodulin-dependent protein kinase kinase-beta. Direct pharmacological and genetic activation of AMPK lowered extracellular Abeta accumulation, whereas AMPK inhibition reduced the effect of resveratrol on Abeta levels. Furthermore, resveratrol inhibited the AMPK target mTOR (mammalian target of rapamycin) to trigger autophagy and lysosomal degradation of Abeta. Finally, orally administered resveratrol in mice was detected in the brain where it activated AMPK and reduced cerebral Abeta levels and deposition in the cortex. These data suggest that resveratrol and pharmacological activation of AMPK have therapeutic potential against Alzheimer disease.
Skin barrier in rosacea (2016)

Recent studies about the cutaneous barrier demonstrated consistent evidence that the stratum corneum is a metabolically active structure and also has adaptive functions, may play a regulatory role in the inflammatory response with activation of keratinocytes, angiogenesis and fibroplasia, whose intensity depends primarily on the intensity the stimulus. There are few studies investigating the abnormalities of the skin barrier in rosacea, but the existing data already show that there are changes resulting from inflammation, which can generate a vicious circle caused a prolongation of flare-ups and worsening of symptoms. This article aims to gather the most relevant literature data about the characteristics and effects of the state of the skin barrier in rosacea.
Functional characterization of a recombinant form of the C-terminal, globular head region of the B-chain of human serum complement protein, C1q (1998)

The first step in the activation of the classical pathway of the complement system by immune complexes involves the binding of the six globular heads of C1q to the Fc regions of IgG or IgM. The globular heads of C1q are located C-terminal to the six triple-helical stalks present in the molecule; each head is considered to be composed of the C-terminal halves (3x136 residues) of one A-, one B- and one C-chain. It is not known if the C-terminal globular regions, present in each of the three types of chain, are independently folded modules (with each chain having distinct binding properties towards immunoglobulins) or whether the different binding functions of C1q are dependent upon a globular structure which relies on contributions from all three chains. As a first step towards addressing this question, we have expressed the globular head region (residues 87-226) of the C1q B-chain (ghB) as a soluble fusion protein with maltose-binding protein (MBP) in Escherichia coli. The affinity purified fusion protein, designated MBP-ghB, behaved as a dimer on gel filtration and bound preferentially to aggregated IgG rather than to IgM. It could also inhibit C1q-dependent haemolysis of both IgG- and IgM-sensitized erythrocytes. After its release from MBP, by use of Factor Xa, the free ghB exhibited a tendency to aggregate and come out of solution. Since MBP is known to be a monomeric molecule, the dimerization of the MBP-ghB fusion polypeptide is probably brought about by the ghB region, perhaps through hydrophobic interactions within the ghB region. The functional behaviour of MBP-ghB indicates that the globular regions of C1q may adopt a modular organization, i.e. each globular head of C1q may be composed of three structurally and functionally independent domains, thus retaining multivalency in the form of a heterotrimer.
Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability (2010)

VEGF was first described as vascular permeability factor, a potent inducer of vascular leakage. Genetic evidence indicates that VEGF-stimulated endothelial proliferation in vitro and angiogenesis in vivo depend on heparan sulfate, but a requirement for heparan sulfate in vascular hyperpermeability has not been explored. Here we show that altering endothelial cell heparan sulfate biosynthesis in vivo decreases hyperpermeability induced by both VEGF(165) and VEGF(121). Because VEGF(121) does not bind heparan sulfate, the requirement for heparan sulfate suggested that it interacted with VEGF receptors rather than the ligand. By applying proximity ligation assays to primary brain endothelial cells, we show a direct interaction in situ between heparan sulfate and the VEGF receptor, VEGFR2. Furthermore, the number of heparan sulfate-VEGFR2 complexes increased in response to both VEGF(165) and VEGF(121). Genetic or heparin lyase-mediated alteration of endothelial heparan sulfate attenuated phosphorylation of VEGFR2 in response to VEGF(165) and VEGF(121), suggesting that the functional VEGF receptor complex contains heparan sulfate. Pharmacological blockade of heparan sulfate-protein interactions inhibited hyperpermeability in vivo, suggesting heparan sulfate as a potential target for treating hyperpermeability associated with ischemic disease.
Design of Wideband Sampled-Data Filters (1964)

A design procedure is presented for readily obtaining sampled-data filter representations of continuous filters. The procedure utilizes the bilinear z transformation and preserves the essential amplitude characteristics of the continuous filter over the frequency range between zero and one-half the sampling frequency. It is shown that the procedure can yield meaningful sampled-data filter designs for many of those filters where the standard z transform cannot be used directly.
High-Temperature Corrosion in Gas Turbines and Steam Boilers by Fuel Impurities. I. Measurement of Nickel Alloy Corrosion Rate in Molten Salts by Linear Polarization Technique (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh-Temperature Corrosion in Gas Turbines and Steam Boilers by Fuel Impurities. I. Measurement of Nickel Alloy Corrosion Rate in Molten Salts by Linear Polarization TechniqueW. R. May, M. J. Zetlmeisl, Lewis Bsharah, and R. R. AnnandCite this: Ind. Eng. Chem. Prod. Res. Dev. 1972, 11, 4, 438–443Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://pubs.acs.org/doi/10.1021/i360044a016https://doi.org/10.1021/i360044a016research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The origin of the broadband luminescence and the effect of nitrogen doping on the optical properties of diamond films (1994)

Raman and various photoluminescence (PL) techniques were employed to investigate the role of nitrogen doping on the optical spectra of chemical-vapor-deposited (CVD) diamond films and to determine the origin of the characteristic broadband luminescence which is observed from approximately 1.5 to 2.5 eV and centered at ∼2 eV. The PL transitions attributed to the zero-phonon lines (ZPL) of nitrogen centers are observed at 1.945 and 2.154 eV. A new possible nitrogen center at 1.967 eV is also observed as well as the band A luminescence centered at ∼2.46 eV. The experimental results preclude the possibility of the broadband PL being due to electron-lattice interaction of the nitrogen ZPL centers. We establish the presence of an in-gap state distribution in CVD diamond films attributed to the sp2 disordered phase and show that its optical transitions are the likely cause of the broadband luminescence. A model of the in-gap state distribution is presented which is similar to models previously developed for amorphous materials.
Suffering in silence (1993)

Live biotherapeutic products constitute an emerging therapeutic approach to prevent or treat inflammatory bowel diseases. Lactobacillus acidophilus is a constituent of the human microbiota with probiotic potential, that is illustrated by improvement of intestinal inflammation and antimicrobial activity against several pathogens. In this study, we evaluated the immunomodulatory properties of the L. acidophilus strain BIO5768 at steady state and upon acute inflammation. Supplementation of naïve mice with BIO5768 heightened the transcript level of some IL-17 target genes encoding for protein with microbicidal activity independently of NOD2 signaling. Of these, the BIO5768-induced expression of Angiogenin-4 was blunted in monocolonized mice that are deficient for the receptor of IL-17 (but not for NOD2). Interestingly, priming of bone marrow derived dendritic cells by BIO5768 enhanced their ability to support the secretion of IL-17 by CD4<sup>+</sup> T cells. Equally of importance, the production of IL-22 by type 3 innate lymphoid cells is concomitantly heightened in response to BIO5768. When administered alone or in combination with Bifidobacterium animalis spp. lactis BIO5764 and Limosilactobacillus reuteri, BIO5768 was able to alleviate at least partially intestinal inflammation induced by Citrobacter rodentium infection. Furthermore, BIO5768 was also able to improve colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). In conclusion, we identify a new potential probiotic strain for the management of inflammatory bowel diseases, and provide some insights into its IL-17-dependent and independent mode of action.
The H5N1 Influenza Virus NS Genes Selected after 1998 Enhance Virus Replication in Mammalian Cells (2007)

The NS1A proteins of human influenza A viruses bind CPSF30, a cellular factor required for the processing of cellular pre-mRNAs, thereby inhibiting the production of all cellular mRNAs, including beta interferon mRNA. Here we show that the NS1A protein of the pathogenic H5N1 influenza A/Hong Kong/483/97 (HK97) virus isolated from humans has an intrinsic defect in CPSF30 binding. It does not bind CPSF30 in vitro and causes high beta interferon mRNA production and reduced virus replication in MDCK cells when expressed in a recombinant virus in which the other viral proteins are encoded by influenza A/Udorn/72. We traced this defect to the identities of amino acids 103 and 106 in the HK97 NS1A protein, which differ from the consensus amino acids, F and M, respectively, found in the NS1A proteins of almost all human influenza A virus strains. X-ray crystallography has shown that F103 and M106, which are not part of the CPSF30 binding pocket of the NS1A protein, stabilize the NS1A-CPSF30 complex. In contrast to the HK97 NS1A protein, the NS1A proteins of H5N1 viruses isolated from humans after 1998 contain F103 and M106 and hence bind CPSF30 in vitro and do not attenuate virus replication. The HK97 NS1A protein is less attenuating when expressed in a virus that also encodes the other internal HK97 proteins and under these conditions binds to CPSF30 to a substantial extent in vivo. Consequently, these internal HK97 proteins largely compensate for the absence of F103 and M106, presumably by stabilizing the NS1A-CPSF30 complex.
Conversion of Monuron to Ethyl-N-p-chlorophenyl Carbamate by Soxhlet Extraction of Plant Tissue with Ethanol (1971)

Abstract Soxhlet extraction of plant materials with alcohol converted monuron residue to carbamate. Although this conversion will not affect the accuracy of monuron determination by the Bratton-Marshall reaction, it will undoubtedly affect the accuracy if the measurement is carried out by thin layer or paper chromatography. Diuron, fenuron, and chloroxuron, which contain 1,1-dimethyl substitution, were also converted to the corresponding carbamates, while siduron, neburon, linuron, monomethyl monuron, monomethyl diuron, and p-chlorophenyl urea were not. When monuron was refluxed with other alcohols such as methanol, isopropanol, and n-butanol, monuron was also converted to other products.
Interactive 3‐dimensional segmentation method based on region growing method (1994)

Abstract It has become easy to obtain three‐dimensional (3D) data of the inside of the human body because of developments in X‐ray computed tomography (CT) and magnetic resonance imaging (MRI). The 3D images of internal organs constructed from these data are useful in understanding the 3D shapes and positional relationships of the organs and are expected to be the diagnostic images of the next generation. However, many problems remain to be solved in making them practical, such as, improving the display speed of 3D images and implementing a 3D interface. For MRI, in particular, the difficulty in segmenting the display image is becoming a major impediment to the practical use of 3D MRI images. In this paper, we propose a practical segmentation method in which interactive corrective operations for 3D images are included in 3D region growing. To implement this method, we developed a 3D monitoring function for the segmentation process and an automatic function for removing the leaks generated during region growing. This method was applied to several 3D MRI data of the head and its effectiveness was confirmed.
There are no Fullerenes in the K-T Boundary Layer (2000)

Abstract Careful re-examination of the Cretacous-Tertiary boundary layer material that was reported earlier to contain C60, confirms that there is a peak in the HPLC of the extract having a retention time similar to that of C60 (the basis of the earlier claim). However, mass spectrometric analysis shows this to be merely a mixture of hydrocarbons. No traces of either C60 or C70 are present under conditions capable of detecting as little as 50 pg (0.001 part per billion in the original material), this sensitivity being four times greater than that given in the earlier report. These findings are entirely consistent with the known high oxidative instability of fullerenes.
Structural characterization of low-defect-density silicon on sapphire (1983)

The structure of (100) silicon on (11̄02) sapphire is discussed for films grown by a special, defect-limiting process. A three-epitaxial-step technique, which utilizes both vapor phase epitaxy and solid phase epitaxy, is employed in the fabrication of low-defect-density films. The effects of different Si+ implantation energies and initial Si film thicknesses on the final structure of the film are investigated in order to optimize the electrical characteristics. The improvement in crystalline quality during the solid phase epitaxy step is due to overgrowth of the {221}-oriented microtwins by the [001) Si matrix. Both Rutherford backscattering spectroscopy and cross-sectional transmission electron microscopy are used in the analysis of the structure of these films.
[Use of non-linearly transformed speech signals for studying the auditory analyzer]. (1986)

An opportunity to apply non-linearly transformed speech signals for investigation of auditory analyzer in health and disease is analysed. Possible types of non-linear transformations preserving semantics of initial speech signals are discussed and analytic expressions are derived. Some circuitry problems related to performing these types of transformations are examined. The results of psycho-acoustic experiments on perception of non-linearly transformed speech signals are given.
Ecgonine Methyl Ester, A Major Metabolite of Cocaine (1982)

Most assays for the identification of cocaine use are aimed at detection of benzoylecgonine, a major urinary metabolite. Gas chromatography assays require derivatization of benzoylecgonine. Recently, ecgonine methyl ester (methylecgonine) has been shown to be major urinary metabolite of cocaine in man after oral administration. These results indicate that ecgonine methyl ester is a prominent urinary metabolite after street use of cocaine, which primarily involves intranasal application and intravenous injection rather than ingestion. Advantages of GC/MS analysis for ecgonine methyl ester in identifying cocaine use include the ability to chromatograph it on common stationary phases without derivatization and its early elution.
1,4,5,6-Tetrahydro-as-triazines. I. Sulfuric Acid Catalyzed Condensation of Nitriles and Hydrazino Alcohols<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,4,5,6-Tetrahydro-as-triazines. I. Sulfuric Acid Catalyzed Condensation of Nitriles and Hydrazino Alcohols1Donald L. Trepanier, Eugene R. Wagner, Guy Harris, and Allan D. RudzikCite this: J. Med. Chem. 1966, 9, 6, 881–885Publication Date (Print):November 1, 1966Publication History Published online1 May 2002Published inissue 1 November 1966https://pubs.acs.org/doi/10.1021/jm00324a024https://doi.org/10.1021/jm00324a024research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A PRACTICAL SHAPE-MEMORY ELECTROMECHANICAL ACTUATOR (1984)

A practical one-pound, three-quarter-inch-stroke, linear actuator using shape-memory effect (SME) metal is described. The actuator is a helical spring made with nickel-titanium shape-memory metal alloy. It compresses or shrinks when heated with an electric current. Design of the actuator which includes protection against ancillary jams is described. Performance data showing actuation time versus applied current, ambient temperature and applied load is presented.
[Incidence, diagnosis, prevention and treatment of insulin allergy]. (1988)

In the Scientific Institute for Endocrinology, Geriatrics and Gerontology, Sofia, 1723 diabetic patients were treated with insulin during the last 3 years. In 150 of them insulin allergy was supposed. The patients sensitivity toward the various insulin preparations was determined by intradermal test. Insulin allergy was found in 29 patients (1.68%). Insulin allergy was found more frequently in patients using acid insulin preparations and by frequent changes of the type of preparation. It is recommended that in special categories of diabetic patients--such as growing up, pregnant women, with complications of insulin treatment--only neutral, swine and purified insulin preparation should be used.
EMOTIONAL AND COGNITIVE CHANGES IN THE POST-TRAUMATIC CONFUSIONAL STATE (1943)

EMOTIONAL AND COGNITIVE CHANGES IN THE POST-TRAUMATIC CONFUSIONAL STATE A. Paterson A. Paterson Search for other works by this author on: Oxford Academic PubMed Google Scholar British Medical Bulletin, Volume 1, Issue 2, April 1943, Page 20, https://doi.org/10.1093/oxfordjournals.bmb.a070133 Published: 01 April 1943