gebhart/patrepeval huggingface dataset:
Cardiac Imaging by Means of Electrocardiographically Gated Multisection Spiral CT: Initial Experience (2000)

The authors introduce a method for cardiac investigations by using electrocardiographically gated spiral scanning with a four-section computed tomographic system. Three-dimensional images were reconstructed by means of a 250-msec temporal resolution and continuous volume coverage by using a dedicated multisection cardiac volume reconstruction algorithm. Motion-free thin-section volume images were acquired with thin sections and overlapping image increments within a single breath hold. Data segment shifts in time allowed for multiphase imaging.
Porcine antimicrobial peptides: New prospects for ancient molecules of host defense (2000)

Antimicrobial peptides (AMPs) are small, endogenous, polycationic molecules that constitute a ubiquitous and significant component of innate immunity. These natural antibiotics have broad microbicidal activity against various bacteria, fungi, and enveloped viruses. Because most AMPs kill bacteria by physical disruption of cell membranes, which may prevent microorganisms from developing resistance against these agents, they are being explored as possible alternatives to conventional antibiotics. Pigs, like many other mammals, produce an impressive array of AMPs, which are synthesized predominantly by host leukocytic phagocytes or mucosal epithelial cells. Currently, more than a dozen distinct porcine AMPs have been identified and a majority belongs to the cathelicidin family. This review briefly summarizes recent advances in porcine AMP research with an emphasis on the diverse biological functions of each peptide. Mechanisms of action of these AMPs and their role in the resistance to infections are considered. Finally, the current status of pharmaceutical and agricultural uses of AMPs as well as future prospects for their application in the food animal industry is discussed.
Resistance Profile of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor Abacavir (1592U89) after Monotherapy and Combination Therapy (2000)

Abacavir (1592U89) is a nucleoside inhibitor of human immunodeficiency virus (HIV) type 1 reverse transcriptase (RT). Resistance to abacavir was studied with abacavir alone and with abacavir in combination with other nucleoside analogues in cell culture, in virus isolates from zidovudine/lamivudine clinical trials, and in the first dose-escalating 12-week clinical trial (CNA2001) to evaluate abacavir clinical potency. Abacavir alone in vitro selected for mutations at HIV RT codons K65R, L74V, Y115F, and M184V. However, abacavir combined with zidovudine selected against virus with the M184V mutation. Abacavir therapy in vivo resulted in large decreases in HIV load (>1 log), even in 1 subject who had the M184V mutation at baseline. A total of 51% of subjects showed new mutations at any of codons K65R, L74V, and M184V after abacavir monotherapy, compared with 11% who received zidovudine/abacavir. Small changes (2- to 4-fold) in abacavir susceptibility were detected. On stopping therapy, reselection of the pretherapy sequence occurred within 4 weeks.
S Phase and Meristem-specific Expression of the Tobacco RNR1b Gene Is Mediated by an E2F Element Located in the 5′ Leader Sequence (2002)

The RB/E2F pathway is involved in the control of the G(1)/S transition of the eukaryotic cell cycle where various S phase genes are activated by specific E2F factors. Ribonucleotide reductase (RNR) plays an essential role in the DNA synthesis pathway. Earlier studies showed that there are at least two RNR1 genes (RNR1a and RNR1b) and one RNR2 gene in tobacco. In synchronized tobacco BY2 cells, RNR1b gene expression is at its highest level in S phase. To investigate transcriptional regulation of the RNR1b gene, its promoter region was cloned and sequenced. Unlike its animal counterparts, the tobacco RNR1b promoter contains a consensus E2F-binding site. Surprisingly, this site is found in the leader sequence of the gene. We show here by gel shift analysis and antibody competition that one nuclear complex specifically binds this motif, and an E2F factor is part of this complex. Using reporter gene analysis, tobacco RNR1b promoter activity was detected during S phase in synchronized cells and in plant meristematic tissues. Mutation of the E2F element substantially reduced both activities. For the first time in plants, a single E2F motif found in the leader sequence plays an important role in the meristem and S phase-specific expression of the tobacco RNR1b gene.
Recent Advances in Haematology. (1978)

Haemopoietic growth factors signal transduction in haemopoietic cells thalassaemia gene rearrangement in leukaemia and lymphomas cytogenetics of acute leukaemia oncogenes in leukaemogenesis and lympomas chronic granulocytic leukaemia chronic lympocytic leukaemia and related diseases the management of Hodgkin's and non-Hodgkin's lymphoma biological and therapeutic aspects of multiple myeloma bone marrow transplantation molecular aspects of haemostasis thrombolytic therapy the general control of haemostasis with particular emphasis on proteins C, S and thrombomodulin AIDS and haematology.
Secondary electron emission characteristics of molybdenum-masked, ion-textured OFHC copper (1990)

A method for producing a uniform, highly textured surface on oxygen-free, high conductivity (OFHC) copper by ion bombardment using sputtered molybdenum as a texture-inducing masking film was developed and used to provide samples for study. The purpose was to develop a basically OFHC copper surface having very low secondary electron emission characteristics. Surfaces having low secondary electron emission are a requirement for the electrodes of very high efficiency multistage depressed collectors (MDC's). Such MDC's are used in microwave amplifier traveling wave tubes for space communications and other applications. OFHC copper is the material most commonly used for MDC electrodes because it has high thermal conductivity, it is easy to machine, and its fabrication and brazing procedures are well established. However, its untreated surface displays relatively very high levels of secondary electron emissions. Textured OFHC copper samples were tested for true secondary electron emission and relative reflected primary electron yield at primary electron beam energy levels from 200 to 2000 eV and at direct (0 deg) to oblique (60 deg) beam impingement angles. The test results for three of the samples, each of which was processed in a slightly different way, are compared with each other and with test results for a machined OFHC copper sample. Although the textured samples are not represented here as having been processed optimally, their measured secondary electron emission characteristics are significantly lower than those of the untreated OFHC copper sample over the range of conditions studied. Importantly, the relative reflected primary electron yield of one of the textured samples is conspicuously lower than that of the others. Clearly, with further development, the molybdenum-masked ion-textured OFHC copper surface will be a promising material for high-efficiency MDC electrodes.
The Production of Volatile Fatty Acids and Carbon Dioxid by Propionic Acid Bacteria with Special Reference to their Action in Cheese (1923)

Summary Observations are recorded concerning the action of Bact. acidipropionici ( d ), the causal factor in the production of eyes and the characteristic sweetish flavor of Swiss cheese, upon various substances which occur in cheese. Aside from its previously known action upon lactose and lactates, it has been found that this organism can produce carbon dioxid, propionic acid and acetic acid from succinates, glycerol, nitrogenous compounds (pepton), and perhaps to a slight degree, from butterfat. From pepton the proportion of acetic acid to propionic acid produced was greater than in the cases of the other substances acted upon. Aspartic acid was shown to be able to serve as a source of acetic acid and carbon dioxid.
[Cell transplantation and gene therapy in Parkinson disease]. (1996)

In 1995 the Anders Jahre Prize for medical research was shared by Professor Lars Olson, Stockholm (Nord Med 1/96), and Professor Anders Björklund, Lund. Using newly developed methods, Anders Björklund has mapped important parts of the central nervous system and neurotransmitters in the brain. Björklund and co-workers have therapeutically transplanted neurones to parts of the brain that, owing to disease or injury, are deficient in essential neurotransmitters. During recent years, the transplantation of fetal nerve cells has been introduced as a possible new therapeutic procedure in Parkinson's disease. Although promising results have been obtained in clinical trials both in Europe and North America, the technique needs further improvement to enhance cell survival, effectiveness and reproducibility. Moreover, an essential long-term goal is to eliminate dependence on a continuous supply of fetal tissue, which is both ethically and practically problematic. Current research is focused on ways to promote the survival and growth of grafted cells, and on the use of gene transfer procedures to generate alternative dopamine-producing of trophic factor-producing cells.
Industrial and Engineering chemistry (1940)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTIndustrial and Engineering chemistryHarrison E. HoweCite this: Ind. Eng. Chem. 1940, 32, 10, 1281–1283Publication Date (Print):October 1, 1940Publication History Published online1 May 2002Published inissue 1 October 1940https://pubs.acs.org/doi/10.1021/ie50370a001https://doi.org/10.1021/ie50370a001research-articleACS PublicationsRequest reuse permissionsArticle Views15Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Role of Moisture Balance in Wound Healing (2007)

After reading this article and taking the test, the reader should be able to: 1. Discuss the wound healing process and wound assessment. 2. Describe the types of dressings available and how they meet the needs of the individual patient.
Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors. (1994)

This study demonstrates for the first time that direct intramyocardial injection of replication-deficient adenovirus can program recombinant gene expression in the cardiomyocytes of a large animal species with relevance to human physiology. The efficiency of adenovirus-mediated gene transfer is far superior to that of plasmid DNA injection, and this method appears to be capable of producing more recombinant protein. However, the cell-mediated immune response to the Ad5 vector and the limited distribution of reporter gene expression suggest that less immunogenic recombinant vectors and more homogeneous administration methods will be required before Ad5 vectors can be successfully used for phenotypic modulation.
Modulation of colony stimulating factor-induced murine myeloid colony formation by S-peptido-lipoxygenase products. (1986)

Prompted by the observation that the selective blockade of lipoxygenase pathway by known inhibitors of this pathway inhibited the colony stimulating factor (CSF)-induced colony formation in both mouse and human marrow cells and the fact that this inhibitory effect could be reversed by a crude total lipoxygenase extract from an incubation of rat peritoneal neutrophils and arachidonic acid, we investigated which of the two major classes of lipoxygenase products, mono- and dihydroxy fatty acids (5S-hydroxyeicosatetraenoic acid and 5S-, 12R-dihydroxyeicosatetraenoic acid) and the S-peptidohydroxy fatty acids (leukotrienes C4 and D4), is involved in the modulation of CSF-induced colony formation by mouse marrow cells. Data from incubations with synthetic lipoxygenase products revealed that (a) the culture of mouse marrow cells in the presence of varying amounts of purified CSF-I (Mia PaCa 2) with a low concentration (5 micrograms/ml) of nordihydroguaretic acid consistently suppressed CSF-induced colony formation by approximately 40-50%. This concentration of nordihydroguaretic acid selectively inhibits only the lipoxygenase pathway; (b) additions of two S-peptido-hydroxy fatty acids [5S-hydroxy-6R-S-glutathionyl-7,9,11,14-(E,E,Z,Z)-eicosatetraenoic acid and 5S-hydroxy-6R-S-cysteinglycyl-7,9,11,14-(E,E,Z,Z)-eicosatetraenoic acid] to these partially suppressed colonies restored the CSF-induced colony formation to control levels in a dose-dependent manner; and (c) additions of two mono- and dihydroxy acids, 5S-hydroxyeicosatetraenoic acid and 5S-12R-dihydroxyeicosatetraenoic acid [5S, 12R-dihydroxy-6,8,10,14-(Z,E,E,Z)-eicosatetraenoic acid], failed to restore the nordihydroguaretic acid inhibited colony formation. These novel observations underscore the importance of these peptido-5-hydroxy fatty acids and the lipoxygenase pathway in the mechanism of CSF-induced colony formation in mouse marrow cells.
Sharp approximate models of deflection routing in mesh networks (1993)

Deflection routing is a simple, decentralized, and adaptive method for routing data packets in communication networks. The focus of this work is on deflection routing in the Manhattan street network (a two-dimensional directed mesh), although the analytic approach should apply to any regular network. Two approximate performance models that give sharp estimates of the steady-state throughput and the average packet delay for packets admitted to the network are presented. The results of extensive simulation experiments are reported, which corroborate the models' predictions. The results show that deflection routing is very effective. Two measures of the merit of a network for deflection routing are its diameter and its deflection index. Networks are presented whose diameter and deflection index are near the optimal values.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Building the sugarcane genome for biotechnology and identifying evolutionary trends (2014)

This release of sugarcane genomic sequences will advance our understanding of sugarcane genetics and contribute to the development of molecular tools for breeding purposes and gene discovery.
Tomography with grating interferometers at low-brilliance sources (2006)

The coherence requirements for efficient operation of an X-ray grating interferometer are discussed. It is shown how a Talbot-Lau geometry, in which an array of equidistant secondary sources is used, can be used to decouple fringe visibility in the interferometer (and thus, its efficiency) from the total size of the X-ray source. This principle can be used for phase-contrast radiography and tomography with sources of low brilliance, such as X-ray tubes.
Poly Plug--Poly Useful. (1997)

Poly Plug is a multi purpose simple material, used in activities to engage the children in mathematics. Some of these activities are especially meant for primary students.
Bi-prediction combining template and block motion compensations (2011)

This paper introduces a bi-prediction scheme with only a motion overhead as for unidirectional prediction. It combines motion vectors found by template and block matchings with the overlapped block motion compensation (OBMC). An optimal window function is designed based on a model-based framework. Additionally, the concept of adaptive motion merging is incorporated to enable a template-matching-free implementation. Three algorithms featuring different performance and complexity trade-offs are implemented using the TMuC-0.9_HM software and tested with the common test conditions. Relative to the anchor, the best of them achieves an average BD-rate saving of 2.2%, with a minimum of 0.2% and a maximum of 4.7%.
Differences in Adiponectin Protein Expression: Effect of Fat Depots and Type 2 Diabetic Status (2002)

Adiponectin is an adipocyte-derived hormone associated with insulin sensitivity and atherosclerotic risk. As central rather than gluteofemoral fat is known to increase the risk of type 2 diabetes and cardiovascular disease, we investigated the mRNA and protein expression of adiponectin in human adipose tissue depots. RNA was extracted from 46 human adipose tissue samples from non-diabetic subjects aged 44.33 +/- 12.4 with a BMI of 28.3 +/- 6.0 (mean +/- SD). The samples were as follows: 21 abdominal subcutaneous, 13 omentum, 6 thigh; samples were also taken from diabetic subjects aged 66.6 +/- 7.5 with BMI 28.9 +/- 3.17; samples were: 6 abdominal subcutaneous; 3 thigh. Quantitative PCR and Western analysis was used to determine adiponectin content. Protein content studies determined that when compared with non-diabetic abdominal subcutaneous adipose tissue (Abd Sc AT) (values expressed as percentage relative to Abd Sc AT -100 %). Adiponectin protein content was significantly lower in non-diabetic omental AT (25 +/- 1.6 %; p < 0.0001, n = 6) and in Abd Sc AT from diabetic subjects (36 +/- 1.5 %; p < 0.0001, n = 4). In contrast, gluteal fat maintained high adiponectin protein content from non-diabetic patients compared with diabetic patients. An increase in BMI was associated with lower adiponectin protein content in obese ND Abd Sc AT (25 +/- 0.4 %; p < 0.0001). These findings were in agreement with the mRNA expression data. In summary, this study indicates that adiponectin protein content in non-diabetic subjects remains high in abdominal subcutaneous fat, including gluteal fat, explaining the high serum adiponectin levels in these subjects. Omental fat, however, expresses little adiponectin. Furthermore, abdominal and gluteal subcutaneous fat appears to express significantly less adiponectin once diabetic status is reached. In conclusion, the adipose tissue depot-specific expression of adiponectin may influence the pattern of serum adiponectin concentrations and subsequent disease risk.
Cardioprotective effects of selective inhibition of the two complement activation pathways in myocardial ischemia and reperfusion injury. (1995)

The complement (C) system-mediated neutrophil activation, adhesion to the coronary endothelium and accumulation into cardiac tissue are key steps in the pathogenesis of myocardial ischemia-reperfusion (MI/R) injury. We examined the differential role of the classical and the alternative complement pathway in MI/R injury in vivo. Rats were subjected to 20 min of myocardial ischemia followed by 24 h of reperfusion. Either a classical pathway inhibitor [C1 esterase inhibitor (C1-INH) (15 mg/kg)] or an alternative pathway inhibitor soluble complement receptor 1 (sCR1)[des-LHR-A](15 mg/kg) or their vehicle were administered intravenously 1 min prior to reperfusion, and myocardial necrosis (creatine kinase loss) and neutrophil accumulation, cardiac myeloperoxidase activity, were examined. C1-INH significantly attenuated cardiac creatine kinase loss compared to MI/R rats given only vehicle (p < 0.05) 24 h after reperfusion. An alternative pathway inhibitor, sCR1 [des-LHR-A] attenuated myocardial injury to a lesser extent, although it was not significantly different from the value for C1-INH or vehicle. Besides cardiac myeloperoxidase activity, the ischemic cardiac tissue was significantly attenuated by both C1-INH and sCR1[desLHR-A] (p < 0.05 vs. vehicle). Both the classical and alternative pathways may contribute to MI/R injury via a neutrophil-dependent mechanism in vivo. Selective inhibition of the classical pathway of complement activation seems to be slightly more effective in limiting necrotic MI/R injury than the selective alternative pathway inhibition in this 24 h model of reperfusion injury, but equal doses of each inhibitor attenuated neutrophil accumulation.
SURFACE ACOUSTIC WAVE MOTOR USING SILICON SLIDER AND ENERGY CIRCULATION STATOR (2002)

We have proposed HF band (3-30 MHz) and higher frequency surface acoustic wave motors and demonstrated its possibility. With a stator transducer of 15x60x1 mm 3 operating at 9.6 MHz, no-load speed of 1 m/s and maximum output force of 10 N were obtained. In this paper, slider block was designed to improve uniformity of the contact pressure of silicon slider surface. TiN film was deposited on slicon slider to modify the contact pressure distribution in one projection. Friction driving performance was not so reduced. Energy circulation drive was also tested. At higher vibration intensity region that of already reported, higher speed and higher output force were obtained. Stepping motion of motor was also mention.
Property Tax and Urban Sprawl. Theory and Implications for U.S. Cities (2005)

This article attempts a formal analysis of the connection between property tax and urban sprawl in U.S. cities. We develop a theoretical model that includes households (who are also landlords) and land developers in a regional land market. We then test the model empirically based on a national sample of urbanized areas. The results we obtained from both theoretical and empirical analyses indicate that increasing property tax rates reduces the size of urbanized areas.
Strengths and Weaknesses of Immunotherapy for Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis of 12 Randomized Controlled Trials (2012)

Immunotherapy works efficiently on advanced NSCLC patients. Of several immunotherapies, mAb therapy may be a potential immunotherapy for advanced NSCLC patients, and become a standard complementary therapeutic approach in the future if the issues concerning toxicity and allergenicity of mAbs have been overcome.
Localization of optics: Quasiperiodic media (1987)

An experiment to probe the (quasi)localization of the photon is proposed, in which optical layers are constructed following the Fibonacci sequence. The transmission coefficient has a rich structure as a function of the wavelength of light and, in fact, is multifractal. For particular wavelengths for which the resonance condition is satisfied, the light propagation has scaling with respect to the number of layers, as well as an interesting fluctuation.
On the Particles Size Distributions of Diatomaceous Earth and Perlite Granulations (2011)

When filtering products with a high level of non-soluble solids and containing filtration-inhibiting substances, a variety of different filter aids can be used. Among others, kieselguhr and perlite are possible materials for this purpose. The selection of the granulation that should be applied depends on the filtered liquid medium and the desired retention level. While perlite is most commonly used for rough filtration, kieselguhr is also suitable for more subtile filtration. In the paper, particle size distributions of three kieselguhr granulations and a perlite granulation are analysed. Particle sizes are measured by the morphometric method, commonly used in the microbiology. Basic statistic parameters are calculated for all considered samples and compared. The applicability of hyperbolic and log-hyperbolic functions, in describing the particles size distributions of these granulations is verified. Depending on the imposed filtration requirements, this approach enables simple modelling and composition of a wide variety of different granulations characterised by appropriate particle size distributions from a few available granulations.