gebhart/patrepeval huggingface dataset:
ROBO2 Gene Variants Are Associated with Familial Vesicoureteral Reflux (2008)

The SLIT2 receptor ROBO2 plays a key role in the formation of the ureteric bud, and its inactivation in mice leads to supernumerary ureteric bud development, lack of ureter remodeling, and improper insertion of the ureters into the bladder. Recently, two heterozygous ROBO2 missense mutations were identified in two families with primary vesicoureteral reflux occurring in combination with congenital anomalies of the kidney and urinary tract (VUR/CAKUT). This study investigated a possible causal role of ROBO2 gene variants in 95 unrelated patients with primary VUR (n = 78) or VUR/CAKUT. Eighty-two percent of all patients had a family history of genitourinary anomalies. Twenty-four ROBO2 gene variants were identified by direct sequencing of all 26 exons and the exon-intron boundaries. Of these, four led to amino acid substitutions: Gly328Ser, Asn515Ile, Asp766Gly, and Arg797Gln. When the families were examined, the missense variants co-segregated with VUR (three families) or VUR/CAKUT (one family). These variants were not found in 190 control subjects, and the affected amino acids have been conserved through evolution. In conclusion, a relatively high frequency of ROBO2 variants (5.1%) was found in familial cases; however, functional studies and validation in other cohorts are warranted.
Mapping of the SecA Signal Peptide Binding Site and Dimeric Interface by Using the Substituted Cysteine Accessibility Method (2013)

SecA is an ATPase nanomotor critical for bacterial secretory protein translocation. Secretory proteins carry an amino-terminal signal peptide that is recognized and bound by SecA followed by its transfer across the SecYEG translocon. While this process is crucial for the onset of translocation, exactly where the signal peptide interacts with SecA is unclear. SecA protomers also interact among themselves to form dimers in solution, yet the oligomeric interface and the residues involved in dimerization are unknown. To address these issues, we utilized the substituted cysteine accessibility method (SCAM); we generated a library of 23 monocysteine SecA mutants and probed for the accessibility of each mutant cysteine to maleimide-(polyethylene glycol)2-biotin (MPB), a sulfhydryl-labeling reagent, both in the presence and absence of a signal peptide. Dramatic differences in MPB labeling were observed, with a select few mutants located at the preprotein cross-linking domain (PPXD), the helical wing domain (HWD), and the helical scaffold domain (HSD), indicating that the signal peptide binds at the groove formed between these three domains. The exposure of this binding site is varied under different conditions and could therefore provide an ideal mechanism for preprotein transfer into the translocon. We also identified residues G793, A795, K797, and D798 located at the two-helix finger of the HSD to be involved in dimerization. Adenosine-5'-(γ-thio)-triphosphate (ATPγS) alone and, more extensively, in conjunction with lipids and signal peptides strongly favored dimer dissociation, while ADP supports dimerization. This study provides key insight into the structure-function relationships of SecA preprotein binding and dimer dissociation.
Espresso: Efficient Forward Propagation for BCNNs (2017)

There are many applications scenarios for which the computational performance and memory footprint of the prediction phase of Deep Neural Networks (DNNs) needs to be optimized. Binary Neural Networks (BDNNs) have been shown to be an effective way of achieving this objective. In this paper, we show how Convolutional Neural Networks (CNNs) can be implemented using binary representations. Espresso is a compact, yet powerful library written in C/CUDA that features all the functionalities required for the forward propagation of CNNs, in a binary file less than 400KB, without any external dependencies. Although it is mainly designed to take advantage of massive GPU parallelism, Espresso also provides an equivalent CPU implementation for CNNs. Espresso provides special convolutional and dense layers for BCNNs, leveraging bit-packing and bit-wise computations for efficient execution. These techniques provide a speed-up of matrix-multiplication routines, and at the same time, reduce memory usage when storing parameters and activations. We experimentally show that Espresso is significantly faster than existing implementations of optimized binary neural networks ($\approx$ 2 orders of magnitude). Espresso is released under the Apache 2.0 license and is available at http://github.com/fpeder/espresso.
Herbal Principles in Cosmetics: Properties and Mechanisms of Action (2010)

The skin : morphophysiological traits and disease -- Botanical compounds and their dermatological and cosmetic uses -- Herbal cosmetic formulations : a fuzzy line between actives and vehicles -- Monographs of herbal principles.
Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation. (1995)

Tax protein of HTLV-1 stimulates transcription of specific cellular genes through the NF-kappa B binding site. We previously showed that Tax binds to the ankyrin motifs of I kappa B-gamma, and dissociates the I kappa B-gamma/NF-kappa B complexes, resulting in nuclear translocation of NF-kappa B proteins. We herein report the effects of Tax on I kappa B-alpha, another member of I kappa B family proteins expressed in human T cells. Tax binds to I kappa B-alpha and partially dissociates the NF-kappa B/I kappa B-alpha complex in vitro. In Tax-expressing cells, Tax/I kappa B-alpha complex was detected only at low level, but NF-kappa B/I kappa B-alpha complex was mostly dissociated and NF-kappa B was translocated into the nucleus. Furthermore, Tax induced reduction of I kappa B-alpha protein. I kappa B-alpha protein was stabilized by NF-kappa B protein through forming NF-kappa B/I kappa B-alpha complex, but Tax expression cancelled this stabilization effect on I kappa B-alpha. These findings suggest that Tax induces dissociation of and/or inhibits the formation of NF-kappa B/I kappa B-alpha complexes, resulting in release of NF-kappa B and destabilization of I kappa B-alpha. Consistently, transcription of NF-kappa B directed gene was activated. These Tax effects counteract the negative feedback control of NF-kappa B by I kappa B-alpha and contribute to constitutive activation of NF-kappa B in Tax-transfected and HTLV-1-infected cells.
Correction of the spherical aberration of a 200 kV TEM by means of a hexapole-corrector (1995)

Correction of the spherical aberration of a 200 kV TEM by means of a Hexapole-corrector. A spherical aberration corrector for a 200kV Transmission Electron Microscope (TEM) has been designed, constructed and tested. This development makes an improvement in the resolving power of modern, spherical aberration limited TEMs possible. The corrector was first tested on an electron optical test-bench so that the correction principle could be checked. With this test-bench the symmetry of the various multipole-fields generated with the multipole-elements could be tested and the high number of individual coils was trimmed in order to attain the required precise symmetry of the multipole-fields. In a second step the corrector was incorporated in a 200 kV TEM in order to demonstrate the compensation of the spherical aberration of the objective lens with the Hexapole-corrector and to begin the development of fast and reliable alignment procedure. From this would appear that the setup of a C 3 corrected high resolution TEM, equipped with a-field-emission gun (FEG). approaching a point resolution of 1 A (or better) is feasible.
Paper capacitors containing chlorinated impregnants (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPaper capacitors containing chlorinated impregnantsD. A. McLean, L. Egerton, and C. C. HoutsCite this: Ind. Eng. Chem. 1946, 38, 11, 1110–1116Publication Date (Print):November 1, 1946Publication History Published online1 May 2002Published inissue 1 November 1946https://pubs.acs.org/doi/10.1021/ie50443a010https://doi.org/10.1021/ie50443a010research-articleACS PublicationsRequest reuse permissionsArticle Views47Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Performance comparison of cdma2ooo forward power control modes (2004)

Forward power control (FPC) is a key factor influencing the forward link capacity of a CDMA system. The main goal of FPC is to dynamically adjust the allocated power for each user in a manner that meets the required quality of service (e.g. FER) of these users, and as a consequence maximizes system capacity. A fundamental aspect of FPC is the rate and delay at which the mobile station provides the power control feedback to the base station that the latter uses to adjust the forward link power. The cdma2000 Release A standard [TIA/EIA/IS-2000.2-A] defines seven different modes of closed-loop forward power control algorithms. In this paper, we present lab measurements comparing the performance of these modes. Results show that FPC modes with faster feedback rates show significant performance improvements over the slower modes in slow and medium fading conditions, while slower modes perform better in AWGN and fast fading conditions.
Parameter Trajectory Analysis to Identify Treatment Effects of Pharmacological Interventions (2013)

The field of medical systems biology aims to advance understanding of molecular mechanisms that drive disease progression and to translate this knowledge into therapies to effectively treat diseases. A challenging task is the investigation of long-term effects of a (pharmacological) treatment, to establish its applicability and to identify potential side effects. We present a new modeling approach, called Analysis of Dynamic Adaptations in Parameter Trajectories (ADAPT), to analyze the long-term effects of a pharmacological intervention. A concept of time-dependent evolution of model parameters is introduced to study the dynamics of molecular adaptations. The progression of these adaptations is predicted by identifying necessary dynamic changes in the model parameters to describe the transition between experimental data obtained during different stages of the treatment. The trajectories provide insight in the affected underlying biological systems and identify the molecular events that should be studied in more detail to unravel the mechanistic basis of treatment outcome. Modulating effects caused by interactions with the proteome and transcriptome levels, which are often less well understood, can be captured by the time-dependent descriptions of the parameters. ADAPT was employed to identify metabolic adaptations induced upon pharmacological activation of the liver X receptor (LXR), a potential drug target to treat or prevent atherosclerosis. The trajectories were investigated to study the cascade of adaptations. This provided a counter-intuitive insight concerning the function of scavenger receptor class B1 (SR-B1), a receptor that facilitates the hepatic uptake of cholesterol. Although activation of LXR promotes cholesterol efflux and -excretion, our computational analysis showed that the hepatic capacity to clear cholesterol was reduced upon prolonged treatment. This prediction was confirmed experimentally by immunoblotting measurements of SR-B1 in hepatic membranes. Next to the identification of potential unwanted side effects, we demonstrate how ADAPT can be used to design new target interventions to prevent these.
Modeling, tracking and interactive animation of faces and heads//using input from video (2002)

We describe tools that use measurements from video for the extraction of facial modeling and animation parameters, head tracking, and real time interactive facial animation. These tools share common goals but rely on varying details of physical and geometric modeling and in their input measurement system. Accurate facial modeling involves fine details of geometry and muscle coarticulation. By coupling pixel by pixel measurements of surface motion to a physically based face model and a muscle control model, we have been able to obtain detailed spatio temporal records of both the displacement of each point on the facial surface and the muscle control required to produce the observed facial motion. We discuss the importance of this visually extracted representation in terms of realistic facial motion synthesis. A similar method that uses an ellipsoidal model of the head coupled with detailed estimates of visual motion allows accurate tracking of head motion in 3D. Additionally, by coupling sparse, fast visual measurements with our physically based model via an interpolation process, we have produced a real time interactive facial animation/mimicking system.
La conservation et la valorisation de l’Herbier de Tournefort au Muséum national d’Histoire naturelle (2010)

Constitué à la fin du XVIIe siècle, l’Herbier du botaniste Joseph Pitton de Tournefort présenté ici sert aujourd’hui – dans la perspective de la rénovation du bâtiment dit « de Botanique » – de modèle de travail pour l’étude menée au Muséum national d’Histoire naturelle sur la conservation et la valorisation des collections historiques de l’Herbier national et plus généralement pour la réflexion engagée autour de la place de la botanique au sein de l’établissement.
Investigations and measurements of the dynamic performance of high-speed ADCs (1992)

The accuracy of ultra-high-speed analog-to-digital converters (ADCs) decreases at higher input frequencies. This is mainly due to timing mismatches, which cause the comparators to sample different time points of the input signal. Investigations concerning the origin of the aperture uncertainty in a 4-b parallel ADC implemented in a 0.5- mu m GaAs FET technology were performed. On-chip E-beam measurements of the clock distribution for the comparators showed differences of 20 ps between the comparators. To overcome these problems, a GaAs 5-b 1-Gs/s ADC with on-chip track-and-hold circuitry (T&H) was developed. A complete DC and AC characterization of this 5-b ADC using a histogram test, fast Fourier transform (FFT) test, sinewave curve-fitting test, and beat frequency test up to 1.3 GHz was performed. By using the T&H in front of the parallel ADC, 4.6 effective numbers of bits (ENOBs) are achieved at 1-GHz input signal compared to 3.7 ENOBs without T&H.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
X-ray scattering (1990)

New developments in x‐ray scattering are resulting from the use of synchrotron radiation sources, allowing study of anomalous scattering regimes with high energy resolution and polarized light. S matrix calculations of elastic scattering are in good agreement away from edges, while dispersion relations can be used to predict edge region scattering if a sufficiently broad and precise photoabsorption data base is available. A new S matrix calculation of inelastic scattering indicates there are substantial regimes in which the p↘⋅A↘ as well as the usual ’A2’ term will have to be taken into account, and many circumstances in which the p↘⋅A↘ term will dominate.
Apoptosis induction by nitric oxide in adult cardiomyocytes via cGMP-signaling and its impairment after simulated ischemia (2000)

NO induces apoptosis in a cGMP dependent manner in isolated adult cardiomyocytes whereas induction of necrosis seems cGMP-independent. After simulated in vitro ischemia the activation of soluble guanylyl cyclase by NO is transiently inhibited resulting in a transient anti-apoptotic protection.
Study of air interface techniques for wireless LANs (1993)

There have been many different techniques developed to combat the ISI problem. Among them are adaptive equalization, CDMA, various multicarrier schemes and the use of intelligent antennas with diversity and directivity. For the HIPERLAN application, adaptive equalization and multicarrier schemes appear attractive. This paper reports a study of the two techniques, emphasising the critical issues relating to each approach, i.e., RF front-end linearity requirements for multicarrier schemes and base-band processing techniques for equalisation schemes
Intermittent electrical stimulation of the right cervical vagus nerve in salt-sensitive hypertensive rats: effects on blood pressure, arrhythmias, and ventricular electrophysiology (2015)

Hypertension (HTN) is the single greatest risk factor for potentially fatal cardiovascular diseases. One cause of HTN is inappropriately increased sympathetic nervous system activity, suggesting that restoring the autonomic nervous balance may be an effective means of HTN treatment. Here, we studied the potential of vagus nerve stimulation (VNS) to treat chronic HTN and cardiac arrhythmias through stimulation of the right cervical vagus nerve in hypertensive rats. Dahl salt-sensitive rats (n = 12) were given a high salt diet to induce HTN. After 6 weeks, rats were randomized into two groups: HTN-Sham and HTN-VNS, in which VNS was provided to HTN-VNS group for 4 weeks. In vivo blood pressure and electrocardiogram activities were monitored continuously by an implantable telemetry system. After 10 weeks, rats were euthanized and their hearts were extracted for ex vivo electrophysiological studies using high-resolution optical mapping. Six weeks of high salt diet significantly increased both mean arterial pressure (MAP) and pulse pressure, demonstrating successful induction of HTN in all rats. After 4 weeks of VNS treatment, the increase in MAP and the number of arrhythmia episodes in HTN-VNS rats was significantly attenuated when compared to those observed in HTN-Sham rats. VNS treatment also induced changes in electrophysiological properties of the heart, such as reduction in action potential duration (APD) during rapid drive pacing, slope of APD restitution, spatial dispersion of APD, and increase in conduction velocity of impulse propagation. Overall, these results provide further evidence for the therapeutic efficacy of VNS in HTN and HTN-related heart diseases.
The specificity of acid proteinase from Acrocylindrium. (1975)

The specificity of acid proteinase from a strain of Acrocylindrium was investigated using oxidized insulin A- and B-chains and glucagon. The enzyme was considerably specific for the bond involves carboxyl group of tyrosine, phenylalanine or leucine. The enzyme also seems to be considerably active when these amino acid donate amino group to the bond to be hydrolyzed.
Cis-trans photoisomerization in Ru(bpy)2(OH2)22+. Crystal structure of trans-[Ru(bpy)2(OH2)(OH)](ClO4)2 (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCis-trans photoisomerization in Ru(bpy)2(OH2)22+. Crystal structure of trans-[Ru(bpy)2(OH2)(OH)](ClO4)2Bill Durham, Scott R. Wilson, Derek J. Hodgson, and Thomas J. MeyerCite this: J. Am. Chem. Soc. 1980, 102, 2, 600–607Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ja00522a026https://doi.org/10.1021/ja00522a026research-articleACS PublicationsRequest reuse permissionsArticle Views1693Altmetric-Citations203LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Synthesis and Ring-Opening Polymerization of Single-Sized Aromatic Macrocycles for Poly(arylene ether)s (1997)

Single-sized, pure arylene ether macrocycles (11−21) ranging from 30 to 60 atom ring sizes were synthesized in good yields (up to 83%) by the two-component method under high dilution conditions. These macrocycles have unsymmetric structures containing sulfone/ketone or sulfone/phosphine oxide functional groups and have relatively low melting points. The melt ROP of the single-sized macrocycles to form poly(arylene ether)s exhibits two-stage characteristics: the first stage is very fast, presumably driven by the large entropy difference between cyclics and linears; the second stage is very slow and is believed to be diffusion controlled due to the high viscosity created in the first stage reaction. The latter stage leads to incomplete polymerization at the low initiator concentrations (1−3 mol %). At high initiator concentrations (5−7 mol %), 100% conversion is reached due to improved initiator distribution in the macrocycles; however, this reduces the molecular weights of the polymers. The molecular weight is found to build up very rapidly, independent of conversion, reaction time, and type of initiator. The ROP is initiated by CsF and alkali phenoxides. The efficiency of the alkali metal counterion is generally in the order Cs+ > K+ > Na+, while a phenoxide initiator is more efficient than a fluoride initiator. It is also found that the Cs counterion leads to the highest degree of crosslinking. The ROP of cyclic oligomeric mixtures (22) is also reported for comparison; the study shows that the molecular weight depends on time and conversion and that the conversion is sensitive to the content of linear impurities and the average ring size of the cyclic mixtures.
Demonstration of a ouabainlike plasma compound in hypertension prone and hypertension resistant rats. (1985)

Material extracted and partially purified from plasma of the Sabra hypertension prone rats was found to be capable of 1) inhibiting the binding of 3H-ouabain to rat brain synaptosomes, 2) inhibiting the activity of rat brain microsomal Na, K activated adenosine triphosphatase, and 3) increasing the contractile force of rat heart muscle. The results demonstrate the presence of a ouabainlike compound in the plasma of these rats. The plasma concentration of this compound in Sabra hypertension prone rats was 698 +/- 199 nmol/ml in ouabain equivalents (SEM; n = 11) versus 2543 +/- 1140 nmol/ml (n = 9) in the Sabra normotensive strain. The presence of ouabainlike compound in the plasma is consistent with the hypothesis that this compound functions as a hormone that regulates Na, K activated adenosine triphosphatase activity and the physiological processes in which this enzyme is involved.