gebhart/patrepeval huggingface dataset:
Circulation and Chemotaxis of Fetal Hematopoietic Stem Cells (2004)

The major site of hematopoiesis transitions from the fetal liver to the spleen and bone marrow late in fetal development. To date, experiments have not been performed to evaluate functionally the migration and seeding of hematopoietic stem cells (HSCs) during this period in ontogeny. It has been proposed that developmentally timed waves of HSCs enter the bloodstream only during distinct windows to seed the newly forming hematopoietic organs. Using competitive reconstitution assays to measure HSC activity, we determined the localization of HSCs in the mid-tolate gestation fetus. We found that multilineage reconstituting HSCs are present at low numbers in the blood at all timepoints measured. Seeding of fetal bone marrow and spleen occurred over several days, possibly while stem cell niches formed. In addition, using dual-chamber migration assays, we determined that like bone marrow HSCs, fetal liver HSCs migrate in response to stromal cell-derived factor-1a (SDF-1a); however, unlike bone marrow HSCs, the migratory response of fetal liver HSCs to SDF-1a is greatly increased in the presence of Steel factor (SLF), suggesting an important role for SLF in HSC homing to and seeding of the fetal hematopoietic tissues. Together, these data demonstrate that seeding of fetal organs by fetal liver HSCs does not require large fluxes of HSCs entering the fetal bloodstream, and that HSCs constitutively circulate at low levels during the gestational period from 12 to 17 days postconception. Newly forming hematopoietic tissues are seeded gradually by HSCs, suggesting initial seeding is occurring as hematopoietic niches in the spleen and bone marrow form and become capable of supporting HSC selfrenewal. We demonstrate that fetal and adult HSCs exhibit specific differences in chemotactic behavior. While both migrate in response to SDF-1a, fetal HSCs also respond significantly to the cytokine SLF. In addition, the combination of SDF-1a and SLF results in substantially enhanced migration of fetal HSCs, leading to migration of nearly all fetal HSCs in this assay. This finding indicates the importance of the combined effects of SLF and SDF-1a in the migration of fetal HSCs, and is, to our knowledge, the first demonstration of a synergistic effect of two chemoattractive agents on HSCs.
Substrate Coupling Analysis and Noise Reduction Methods (2001)

The trend of system-on-a-chip carries on the end of the VLSI era to fulfill the ever-rising demands of electronics industry. As system complexity increases, interconnect becomes the dominant factor over transistor sizes in determining the overall performance. Theoretically, systems-on-a-chip implementations eliminate most packaging interfaces to improve the system-level performance. Manufacturing cost is also reduced by integrating both analog and digital circuits using monolithic CMOS technologies. Unfortunately, substrate coupling is found to be a major obstacle for the advancement of system-on-a-chip. Accurate predictions of substrate coupling in large-scale systems demand a modeling algorithm with high speed and high resolution, which are difficult to achieve simultaneously. This thesis provides a comprehensive approach towards predicting and preventing substrate noise coupling issues in large systems efficiently. We are primarily interested in modeling the epitaxial-type heavily-doped bulk substrate, that is commonly used in system-on-a-chip designs. An efficient substrate parasitics extraction algorithm based on Delaunay triangulation is proposed. It is optimized for large-scale design applications. Active noise suppression circuits that improve guard band noise insulation efficiency are also developed. SPICE simulation results of circuit layouts comprising the proposed substrate model are compared against those with substrate models generated from Cadence AssuraRTM Substrate Coupling Analysis tool. Various experiments are performed to obtain fabrication-related substrate parameters, measure the circuit performance and validate the modeling results.
The Effect of Annealing on the Electrical Properties of Selectively Doped GaAs/N-AlGaAs Heterojunction Structures Grown by MBE (1981)

The effect of annealing on the electrical properties of selectively doped GaAs/N-AlGaAs heterojunction structures grown by MBE has been studied. Very high electron mobility in this structure at 77 K decreased considerably after annealing at about 700°C. However, it remained at a high value even after annealing when the Si doping concentration in N-AlGaAs was reduced to about 1×10 18 cm -3 . These results are discussed in terms of diffusion of Si impurities doped in N-AlGaAs.
FT Raman and FTIR studies of titanias and metatitanate powders (1994)

FT Raman and FTIR/FTFIR skeletal spectra of different TiO2 powders, of both synthetic and commercial origin, and of Sr, Ba, Co and Ni metatitanates are reported and discussed in relation to the predictions of factor group analyses. The ability of vibrational techniques to show the presence of brookite impurities in both anatase and rutile, and of rutile in anatase, as well as to give morphological and surface information is emphasized. The spectra of SrTiO3, BaTiO3, NiTiO3 and CoTiO3 are also discussed in relation to their different structures (pervoskite and ilmenite-type).
Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance (2012)

Our findings define a subset of transcriptionally regulated genes by selumetinib in GNAQ mutant cells and provide new insights into understanding the biologic effect of MEK inhibition in this disease.
Guidelines for Counsellors Working with People of African Ancestry in a Sport Context (2009)

The objective this article is to describe five practice guidelines for counsellors working with people of African ancestry in a sport context. The practice guidelines pertain to counsellor training, counsellor perspectives, counsellor services, counsellor ethics and counsellor research. These practice guidelines can assist counsellors working with people of African ancestry in a sport context to focus on both personal development through sport and performance enhancement in sport. This will enable athletes not just to view sport in terms of their win-lose record, but to also strive for excellence in sport by becoming better people. In becoming better people athletes can contribute to building up Africa and her people.
On the lattice parameters of GaN (2007)

The lattice parameters of low-defect density, undoped bulk GaN fabricated by hydride vapor phase epitaxy (HVPE) on (0001) sapphire and subsequent substrate removal, are precisely determined using high-resolution x-ray diffraction. The obtained values, c=5.18523Å and a=3.18926Å, are compared with the lattice parameters of freestanding HVPE GaN from different sources and found to be representative for state-of-the-art undoped HVPE bulk GaN material. A comparison with bulk GaN fabricated by the high-pressure technique and homoepitaxial GaN is made, and significant differences in the lattice parameters are found. The observed differences are discussed and a possible explanation is suggested.
The Theory of Blackjack: The Compleat Card Counter's Guide to the Casino Game of 21 (1988)

Introduction The Basic Strategy The Spectrum of Opportunity Exploiting the Spectrum -- Single Parameter Card Counting Systems 5.Multi-Parameter Card Counting Systems Tables & Applications On the Likely Consequences of Errors in Card Counting Systems Many Decks & Different Rules Miscellany Curios & Pathologies in the Game of 21 Some Techniques for Blackjack Computations Update -- Fifth National Conference on Gambling Regression Implications for Blackjack & Baccarat Post-Script 1986 Interactive Approximations to Facilitate Rapid Blackjack Computations.
Tbx6,a Mouse T-Box Gene Implicated in Paraxial Mesoderm Formation at Gastrulation (1996)

The T-box genes constitute an evolutionarily conserved family of putative transcription factors which are expressed in discrete domains during embryogenesis, suggesting that they may play roles in inductive interactions. Members have been identified by virtue of their homology to the prototypical T-box gene, T or Brachyury, which is required for mesoderm formation and axial elongation during embryogenesis. We have previously reported the discovery of six new mouse T-box genes, Tbx1-Tbx6, and described the expression patterns of Tbx1-Tbx5 (Bollag et al., 1994; Agulnik et al., 1996; Chapman et al., 1996; Gibson-Brown et al., 1996). We have obtained cDNA clones encoding the full-length Tbx6 protein from screens of gastrulation-stage mouse cDNA libraries and determined the spatial and temporal distribution of Tbx6 transcripts during embryogenesis. The gene codes for a 1.9-kb transcript with an open reading frame coding for a 540-amino acid protein, with a predicted molecular weight of 59 kDa. Tbx6 maps to chromosome 7 and does not appear to be linked to any known mutation. Unlike other members of the mouse T-box gene family which are expressed in a wide variety of tissues derived from all germ layers, Tbx6 expression is quite restricted. Tbx6 transcripts are first detected in the gastrulation stage embryo in the primitive streak and newly recruited paraxial mesoderm. Later in development, Tbx6 expression is restricted to presomitic, paraxial mesoderm and to the tail bud, which replaces the streak as the source of mesoderm. Expression in the tail bud persists until 12. 5 days postcoitus. Tbx6 expression thus overlaps that of Brachyury in the primitive streak and tail bud, although Brachyury is expressed earlier in the primitive streak. Brachyury is also expressed in a second domain, the node and notochord, that is not shared with Tbx6. The onset of Tbx6 expression is not affected in homozygous null Brachyury mutant embryos at 7.5 days postcoitus. However, Tbx6 expression is extinguished in mutant embryos as soon as the Brachyury phenotype becomes evident at 8.5 days postcoitus, indicating that the continued expression of Tbx6 is directly or indirectly dependent upon Brachyury expression.
Polymorphisms of Coagulation Factor Genes a Review (1998)

Common genetic variants of coagulation factor genes associated with differences in concentration and/or function of coagulation factors have been studied in search of variability that could explain the individual susceptibility to thrombosis and atherothrombotic diseases. The more outstanding polymorphisms in genes of factors involved in coagulation and fibrinolysis described in the literature (such as fibrinogen, factor XIII, glycoprotein IIb/IIIa, von Willebrand factor, factors VII, VIII and IX, factor V, ATIII and protein C system factors, prothrombin, PAI-1 and fibrinolytic system) are reviewed in the context of factor's structure and function and also in its proposed relevance for thrombotic and atherothrombotic risk definition.
<title>Autonomous optical navigation for interplanetary missions</title> (1996)

The automation of interplanetary spacecraft is becoming increasingly desirable to meet various mission requirements. A prototype autonomous spacecraft which will flyby an asteroid and comet is slated for flight in mid-1998 as part of NASA's New Millennium Program. This spacecraft will navigate by using optical data taken by the onboard camera to determine its orbit, and use this information to predict its future trajectory and make necessary course corrections. The basic navigation data available from the camera are star-relative astrometric observations of solar system bodies which can be used to determine line-of-sight vectors to those objects. The directional sightings are obtained by determining the precise centers of the object and stars in the image. During interplanetary cruise, centerfinding is performed by using two pattern matching techniques inherited from the Galileo mission. Near-encounter images are processed with a separate algorithm employing image modeling and brightness centroiding. This paper describes the image processing algorithms, and the results of a ground-based test of the algorithms using real data.
Bean Golden Mosaic Geminivirus Type II Isolates from the Dominican Republic and Guatemala: Nucleotide Sequences, Infectious Pseudorecombinants, and Phylogenetic Relationships (1994)

Bean golden mosaic geminivirus (BGMV) causes major losses on beans (Phaseolus vulgaris) in the tropical and subtropical Americas and the Caribbean Basin. Infectious DNA-A and -B components of BGMV isolates from the Dominican Republic (BGMV-DR) and Guatemala (BGMV-GA) were sequenced, and their genome organizations were similar to those of other whitefly-transmitted geminiviruses from the Western Hemisphere. Whiteflies (Bemisia tabaci) transmitted BGMV from beans infected by particle-gun inoculation with clones of BGMV-DR or -GA. Infectious pseudorecombinants gave symptoms typical of wild-type infections when mixtures of BGMV-GA DNA-A and BGMV-DR DNA-B were used. Delayed and attenuated symptoms were obtained when mixtures of BGMV-DR DNA-A and BGMV-GA DNA-B were used. Phylogenetic analyses using the common region and four open reading frames placed 20 geminiviruses in eight clusters for the Western Hemisphere and at least five clusters for the Eastern Hemisphere viruses. BGMV-DR and -GA are in the BGMV type II cluster with the BGMV isolate from Puerto Rico. The BGMV type II cluster is clearly distinct from the BGMV type I cluster, which contains the BGMV isolate from Brazil. Bean dwarf mosaic geminivirus is in the Abutilon mosaic virus cluster, and bean calico mosaic geminivirus is in the squash leaf curl geminivirus cluster. Conserved nucleotide sequences of the common regions of members of these clusters were identified, and the presence of amino acid motifs with putative functions were identified in the derived amino acid sequences of the replication-associated proteins of BGMV-DR and -GA. The availability of sequenced, infectious clones of BGMV-DR and -GA provides opportunities for the study of genome functions and for the engineering of beans for resistance to these viruses.
A 0.8 mm<sup>2</sup> Sub-GHz GaAs HBT Power Amplifier for 5G Application Achieving 57.5% PAE and 28.5 dBm Maximum Linear Output Power (2019)

This paper presents a comprehensive design of a fully integrated multistage GaAs HBT power amplifier that achieves both linearity and high efficiency within a chip area of 0.855 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for 4G and 5G applications covering the lower frequency band of 700-800 MHz. A novel linearizer circuit is integrated to a dual stage class-AB PA to minimize the AM-PM (Amplitude Modulation-Phase Modulation) distortion generated by the parasitic capacitance at the PN-junction under low bias current condition. The linearized power amplifier is able to operate within a 100 MHz linear operating bandwidth (700-800 MHz) while meeting the adjacent channel leakage ratio (ACLR) specification for 4G and 5G application. The fully integrated PA achieves a wideband efficiency of 57.5% at 28.5 dBm output power. Observing a respective input and output return losses of less than 13 dB and 10 dB, the PA delivers a power gain within the range of 34.0-37.0 dB across the operating bandwidth while exhibiting an unconditional stability characteristic from DC up to 5 GHz. The proposed linearization method paves the way of reducing the complexity of linear and high efficiency PA design which is associated with complicated and high-power consumption linearization schemes.
Efficient learning of variable-resolution cognitive maps for autonomous indoor navigation (1999)

This paper presents an adaptive method that allows mobile robots to learn cognitive maps of indoor environments incrementally and online. Our approach models the environment. By means of a variable-resolution partitioning that discretizes the world in perceptually homogeneous regions. The resulting model incorporates both a compact geometrical representation of the environment and a topological map of the spatial relationships between its obstacle-free areas. The efficiency of the learning process is based on the use of local memory-based techniques for partitioning and of active learning techniques for selecting the most appropriate region to be explored next. In addition, a feedforward neural network is used to interpret sensor readings. We present experimental results obtained with two different mobile robots, the Nomad 200 and Khepera. The current implementation of the method relies on the assumption that obstacles are parallel or perpendicular to each other. This results in variable-resolution partitioning consisting of simple rectangular partitions and reduces the complexity of treating the underlying geometrical properties.
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis (2020)

ClinicalTrials.gov Identifier: NCT02450552.
Interferon Inducing Activity of Polyinosinic Acid (1978)

Although poly(I) is generally considered to be inactive as an interferon inducer, we have found several authentic poly(I) preparations to be effective inducers. Their interferon inducing ability varied considerably from one cell system to another. In human diploid fibroblasts, primed with interferon and superinduced by cycloheximide and actinomycin D, all active poly(I) samples proved nearly as effective in inducing interferon as poly(I).poly(C). In primary rabbit kidney cell cultures, the active poly(I) samples were either as active, or 3 to 30 times less active than poly(I).poly(C). In intact rabbits they were 100 times less active than poly(I).poly(C). Except for one particular sample, all active poly(I) preparations were inferior to poly(I).poly(C) when assayed for interferon induction in interferon-treated mouse L cells; in DEAE-dextran-treated L cells, they induced little, if any, interferon. The poly(I) inducers of interferon were considerably more susceptible to degradation by TI ribonuclease, pancreatic ribonuclease and human serum nuclease(s) than was poly(I).poly(C) when assayed under the same conditions. Due to their limited half-life time in biological fluids, poly(I) analogues such as those described here may offer a greater safety margin in clinical use than poly(I).poly(C).
System impairment due to polarization mode dispersion (2003)

A linear model that determines the eye closure due to polarization-mode dispersion is presented. Current 2.5-Gbit/s systems have minor impairment from PMD; however, systems with increased bit rate and/or PMD could suffer from Q-factor fluctuation primarily and reduced average Q-factor.
Letters (1985)

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Mechanism of Vapor Pressure Depression in Aqueous Mixed Solutions of LiBr and CaCl2. (1991)

開発したLiBr・CaCl2系混合吸収媒体が, 溶解度が低下せずに水蒸気圧低下が起こるメカニズムについて, 水和現象を基にした推算と実験により検討した.水蒸気圧低下には水和した水分子が多い程大きくなるが, 溶解度は構造形成領域に水和した水分子のみが影響することに着目した.他のイオンを添加すると構造形成領域に水和していた水分子の一部が両方のイオンに共通に水和する “水和共有” 現象が起こり, 余った水分子が構造破壊領域へ移動し, 遷移水和領域と水和共有領域が形成されるため, 水蒸気圧低下が促進されるメカニズムを提案した.さらに水和共有が有る場合の混合水溶液の水蒸気圧低下率を, 各水和領域毎に水和数と水和力の積で定義した等価水和数を用いて推算した.また, LiBrにCaCl2を添加した時の水蒸気圧を沸点法で実測し, その結果モル分率 : 0.2～0.6の混合比で水蒸気圧低下率の極大が得られ, 推定値と一致した.
Augmented CycleGAN: Learning Many-to-Many Mappings from Unpaired Data (2018)

Learning inter-domain mappings from unpaired data can improve performance in structured prediction tasks, such as image segmentation, by reducing the need for paired data. CycleGAN was recently proposed for this problem, but critically assumes the underlying inter-domain mapping is approximately deterministic and one-to-one. This assumption renders the model ineffective for tasks requiring flexible, many-to-many mappings. We propose a new model, called Augmented CycleGAN, which learns many-to-many mappings between domains. We examine Augmented CycleGAN qualitatively and quantitatively on several image datasets.
Increase of Travel Safety for Public Transport by Mobile Applications (2013)

Mitigating vandalism in local traffic and at stations, violent disorder, and theft by employing security guards, installing video cameras are expensive and only partially solve existing the problems. Related costs directly affect the fares and thus the attractiveness of local public transport. We discuss a concept to implement a Report-service to forward emergency and complaint messages in local public transport. The service is based on a mobile application and a message routing system. The aim is to increase travel safety and the attractiveness of the local public transport. On the base of theoretical approaches and the usage of paper prototypes we show the possibilities how such a Report-service could be implemented.
Efficacy of chitosan-based nanoparticle vaccine administered to broiler birds challenged with Salmonella (2020)

Two experiments were conducted to evaluate the immune response of broilers vaccinated with Salmonella chitosan-nanoparticle (CNP) vaccine and challenged with Salmonella. The Salmonella CNP vaccine was synthesized with Salmonella enterica outer membrane proteins (OMPs) and flagellin proteins. In Experiment I, birds were orally gavaged with PBS or 500, 1000, or 2000μg of CNP vaccine 1 and 7d-of-age. At 14d-of-age, birds were orally challenged with 1 X 105 CFU/bird of live S. Enteritidis (SE). Macrophage-nitrite production 11d-post-challenge was higher (P<0.05) in the 500μg group when compared to the control. At d14 (8h-post-challenge), broilers vaccinated with 1000μg CNP had higher (P<0.05) serum anti-OMPs IgG and IgA and cloacal anti-OMP IgA amounts. At 11d-post-challenge, birds vaccinated with 1000μg CNP vaccine had greater (P<0.05) bile anti-OMP and anti-flagellin IgA amounts. At 11d-post-challenge, birds administered 1000μg CNP vaccine has increased (P<0.05) IL-1β and IL-10 mRNA in cecal tonsils. In Experiment II, birds were orally gavaged with PBS or 1000μg CNP or a live commercial vaccine at 1 and 7d-of-age. At 14d-of-age, birds were orally challenged with 1 X 105 CFU/bird of live SE or S. Heidelberg (SH). Birds vaccinated with CNP showed higher (P<0.05) serum anti-OMPs IgG amounts at 8h-post-challenge. At 4d-post-SH challenge, birds vaccinated with CNP had higher (P<0.05) bile anti-flagellin IgA amounts. CNP decreased (P<0.05) anti-OMPs IgG levels in serum at 2d-post-SE challenge and 4d-post-SH or SE challenge. Salmonella Enteritidis loads in cecal content at 2d-post-challenge was decreased (P<0.05) by 65.9% in birds vaccinated with CNP, when compared to the control. Chitosan-nanovaccine had no adverse effects on bird's production performance. In conclusion, 1000μg CNP vaccine can induce a specific immune response against Salmonella and has the potential to mitigate SE cecal colonization in broiler birds.
Discrete regions of sequence homology between cloned rodent VL30 genetic elements and AKV related MuLV provirus genomes (1983)

Southern blot analyses using reduced stringency hybridization conditions have been employed to search for sequence homologies between rodent VL30 genes and murine leukemia virus (MuLV) proviruses. These constitute two classes of transposon-like elements previously believed to be genetically unrelated. Our results demonstrate that cloned representatives of both ecotropic and xenotropic-like proviruses share discrete regions of sequence homology with VL30 genes of both rat and mouse origin. These regions of homology exist in both 3' and 5' halves of the MuLV genome but do not include extensive portions of the long terminal repeat (LTR) or a 0.4 Kbp segment of the env gene specific for recently acquired ecotropic-type MuLV proviruses. DNA sequencing, however, revealed that the short inverted terminal repeat sequence of MuLV proviral LTRs is almost perfectly conserved at the terminus of an integrated mouse VL30 gene. These results suggest that recombination events with rodent VL30-type sequences occurred during early MuLV evolution. The strong conservation of the inverted terminal repeat sequence may reflect a common integration mechanism for VL30 elements and MuLV proviruses.