gebhart/patrepeval huggingface dataset:
Piperacillin-Tazobactam versus Other Antibacterial Agents for Treatment of Bloodstream Infections Due to AmpC β-Lactamase-Producing Enterobacteriaceae (2017)

<i>In vivo</i> induction of AmpC beta-lactamases produces high-level resistance to many beta-lactam antibiotics in <i>Enterobacteriaceae</i>, often resulting in the need to use carbapenems or cefepime (FEP). The clinical effectiveness of piperacillin-tazobactam (TZP), a weak inducer of AmpC beta-lactamases, is poorly understood. Here, we conducted a case-control study of adult inpatients with bloodstream infections (BSIs) due to <i>Enterobacter</i>, <i>Serratia</i>, or <i>Citrobacter</i> species from 2009 to 2015 to assess outcomes following treatment with TZP compared to FEP or meropenem (MEM). We collected clinical data and screened all isolates for the presence of <i>ampC</i> alleles by PCR. Primary study outcomes were 30-day mortality and persistent bacteremia at ≥72 h from the time of treatment initiation. Of 493 patients with bacteremia, 165 patients met the inclusion criteria, of which 88 were treated with TZP and 77 with FEP or MEM. To minimize differences between covariates, we carried out propensity score matching, which yielded 41 matched pairs. Groups only differed by age, with patients in the TZP group significantly older (<i>P</i> = 0.012). There were no significant differences in 30-day mortality, persistent bacteremia, 7-day mortality, or treatment escalation between the two treatment groups, including in the propensity score-matched cohort. PCR amplification and sequencing of <i>amp</i>C genes revealed the presence of <i>amp</i>C in isolates with cefoxitin MICs below 16 μg/ml, in particular in <i>Serratia</i> spp., and demonstrated that these alleles were highly genetically diverse. Taken together, TZP may be a valuable treatment option for BSIs due to AmpC beta-lactamase-producing <i>Enterobacteriaceae</i>, diminishing the need for broader-spectrum agents. Future studies are needed to validate these findings.
New circularly polarized planar printed antenna with conical radiation pattern (2002)

The new circularly polarized planar printed antenna concept with conical antenna pattern is presented. The proposed concept features a simple printed structure with omnidirectional pattern and maximum gain of about 6 dBi at the elevation angle from 30/spl deg/ to 60/spl deg/, showing features for various commercial applications. An operational bandwidth of more than 20% for VSWR less than 2 as well as a satisfactory axial ratio is obtained. The concept is verified by measurements.
Prevalence of fragile X syndrome (1996)

The much-quoted prevalence figure of 1:1,000 males for fragile X syndrome is an overestimate in a mixed ethnic population. A reexamination of the individuals from whom those data were derived using molecular diagnostic techniques demonstrates a more realistic figure of 1:4,000 males.
A low-distortion BiCMOS seventh-order Bessel filter operating at 2.5 V supply (1996)

This paper presents the design of a seventh-order continuous-time Bessel filter using a new low-voltage and highly linear BiCMOS transconductor. A high-gain and parasitic-insensitive integrator is obtained by using an active capacitor scheme. The filter has been designed to operate at a 2.5 V supply with a nominal -3 dB cutoff frequency of 600 kHz. It has been fabricated in 1 /spl mu/m, double-poly 6-GHz BiCMOS process. The inband group delay variation is less than 10 ns. The total harmonic distortion (THD) measured with a 100 kHz input signal is less than -49 dB for a 2 V/sub pp/ amplitude and the dynamic range is 77 dB. The filter can be frequency tuned over almost one decade with a gain variation less than 0.2 dB in the passband. A common-mode rejection ratio (CMRR) of 53 dB in the passband is observed, thanks to a careful common-mode control strategy.
Hybrid optical proximity correction: concepts and results (2002)

Optical Proximity Correction (OPC) is increasingly important in the design and manufacturing of integrated circuits, since many of them now contain features which are smaller than the wavelength of light used in lithography. The optical distortions that beset these subwavelength designs are counteracted through the use of OPC, which strategically applies complex corrections to the original features using either a rule-based or model-based approach. Model-based OPC (MOPC) can be very accurate but it suffers from poor speed. Rule-based OPC (ROPC), on the other hand, can convert layouts quickly but at the expense of accuracy. A new concept for optical proximity correction, Hybrid OPC (HOPC), is proposed for enabling the user to control the tradeoff between accuracy and speed of conversion at a fine-grain level of details. Based on feature context, shape, and geometric information such as widths and spacings, HOPC technique can selectively apply MOPC to the most critical regions of the design while allowing the application of ROPC elsewhere. In this paper, we will describe the approach taken as well as provide benchmark data demonstrating the effectiveness of the concept.
Synthesis of Cubic Phase Li7La3Zr2O12 Electrolyte for Solid-State Lithium-Ion Batteries (2011)

We report the synthesis of high-quality cubic-phase Li7La3Zr2O12 powders using a solution based technique. Detailed structural, morphological, compositional and electrochemical characterization of the samples was performed. The lithium-ion conductivity of the cubic-phase Li7La3Zr2O12, determined by electrochemical impedance spectroscopy, was ∼1.67×10−4 S/cm. A proto-type all-solid-state battery with Li7La3Zr2O12 as electrolyte, LiCoO2 as cathode and a Lithium metal foil as anode was assembled. The cell was rechargeable and exhibited a very promising specific discharge capacity of 3.4 mAh/g which corresponds to 2.5% of the theoretical capacity. The above value is the highest discharge capacity reported till date using Li7La3Zr2O12 electrolyte.
1 Ω On-Resistance Diamond Vertical-Schottky Barrier Diode Operated at 250 °C (2013)

Vertical-structured diamond Schottky barrier diodes with a thick field plate have been developed. The diamond VSBD with a 30 µm square (8.8×10-6 cm2) Schottky electrode shows specific on-resistance and blocking voltage, such as 29.3 mΩ cm2 (3.3 kΩ) and 842 V at room temperature, respectively, however, the lower specific on-resistance with a constant blocking voltage such as 9.4 mΩ cm2 (1 kΩ) and 840 V, respectively, have been realized at 250 °C. As a result, Baliga's figure of merit (BVBD2/RonS) is improved from 24.1 to 75.3 MW/cm2. This value is the best in diamond diodes at present. The diamond VSBD with a 1,000 µm square (9.7×10-3 cm2) Schottky electrode shows high forward current and low on-resistance, such as more than 5 A and 10.2 mΩ cm2 (1.04 Ω), respectively, at 250 °C. The estimated parasitic resistance of the SBD is less than 0.04 Ω.
Phenotype-information-phenotype cycle for deconvolution of combinatorial antibody libraries selected against complex systems (2011)

Use of large combinatorial antibody libraries and next-generation sequencing of nucleic acids are two of the most powerful methods in modern molecular biology. The libraries are screened using the principles of evolutionary selection, albeit in real time, to enrich for members with a particular phenotype. This selective process necessarily results in the loss of information about less-fit molecules. On the other hand, sequencing of the library, by itself, gives information that is mostly unrelated to phenotype. If the two methods could be combined, the full potential of very large molecular libraries could be realized. Here we report the implementation of a phenotype-information-phenotype cycle that integrates information and gene recovery. After selection for phage-encoded antibodies that bind to targets expressed on the surface of Escherichia coli, the information content of the selected pool is obtained by pyrosequencing. Sequences that encode specific antibodies are identified by a bioinformatic analysis and recovered by a stringent affinity method that is uniquely suited for gene isolation from a highly degenerate collection of nucleic acids. This approach can be generalized for selection of antibodies against targets that are present as minor components of complex systems.
Control of DFIG-Based Wind Generation to Improve Interarea Oscillation Damping (2009)

Power systems with high penetration of wind power usually require long-distance transmission to export wind power to the market. Interarea oscillation is an issue faced in long-distance transmission. Can wind generation based on doubly fed induction generator (DFIG) help to damp oscillations and how? In this paper, a control scheme is developed for the DFIG with rotor-side converter to damp interarea oscillations. The DFIG is modeled in MATLAB <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reg</sup> /Simulink utilizing its vector control scheme feature, and inner current control and outer active/reactive power control loops are modeled and designed. A two-area system that suffers from poor interarea oscillation damping along with a wind farm in the area that exports power is investigated. A damping controller is designed and time-domain simulations are used to demonstrate the effectiveness of the controller. The major contributions of the paper are as follows: 1) built a wind farm interarea oscillation study system based on the classical two-area four-machine system, 2) established that in vector control scheme, active power modulation can best help to damp oscillations, 3) successfully designed a feedback controller using remote signals with good interarea oscillation observability.
Blackbody Spectrum Revisited in the Near Field (2013)

We report local spectra of the near-field thermal emission recorded by a Fourier transform infrared spectrometer, using a tungsten tip as a local scatterer coupling the near-field thermal emission to the far field. Spectra recorded on silicon carbide and silicon dioxide exhibit temporal coherence due to thermally excited surface waves. Finally, we evaluate the ability of this spectroscopy to probe the frequency dependence of the electromagnetic local density of states.
Mechanical fragility of erythrocytes in multiple sclerosis (1980)

Erythrocyte fragility was measured by mechanical shaking in 82 normal individuals and 19 patients with multiple sclerosis (MS). On the average, fragility was significantly higher in the MS patients, although this increase did not correlate with the presence of serum neuroelectric blocking factors.
CUDA Compatible GPU as an Efficient Hardware Accelerator for AES Cryptography (2007)

This paper presents a study of the efficiency in applying modern graphics processing units in symmetric key cryptographic solutions. It describes both traditional style approaches based on the OpenGL graphics API and new ones based on the recent technology trends of major hardware vendors. It presents an efficient implementation of the advanced encryption standard (AES) algorithm in the novel CUDA platform by Nvidia. AES is currently the most widely adopted modern symmetric key encryption standard. The performance of the new fastest GPU solution is compared with those of the reference sequential implementations running on an Intel Pentium IV 3.0 GHz CPU. Unlike previous research in this field, the results of this effort show for the first time the GPU can perform as an efficient cryptographic accelerator. The developed solutions run up to 20 times faster than OpenSSL and in the same range of performance of existing hardware based implementations.
Curcumin: clinical trial finds no antiviral effect. (1996)

A New England clinical trial examined curcumin and its effectiveness as an antiviral agent in 40 participants. Viral load tests, including baseline testing, were conducted in the fourth and eighth weeks, following high- and low-dose regimens. The study found no evidence that curcumin reduced viral load or increased CD4 counts. Despite this finding, patients claimed they liked taking curcumin because they felt better and were willing to put up with the minor gastrointestinal effects.
Novel activity of acriflavine against colorectal cancer tumor cells (2011)

A high-throughput screen of the cytotoxic activity of 2000 molecules from a commercial library in three human colon cancer cell lines and two normal cell types identified the acridine acriflavin to be a colorectal cancer (CRC) active drug. Acriflavine was active in cell spheroids, indicating good drug penetration and activity against hypoxic cells. In a validation step based on primary cultures of patient tumor cells, acriflavine was found to be more active against CRC than ovarian cancer and chronic lymphocytic leukemia. This contrasted to the activity pattern of the CRC active standard drugs 5-fluorouracil, irinotecan and oxaliplatin. Mechanistic studies indicated acriflavine to be a dual topoisomerase I and II inhibitor. In conclusion, the strategy used seems promising for identification of new diagnosis-specific cancer drugs.
Biometrika Tables for Statisticians. (1973)

(1974). Biometrika Tables for Statisticians, Volume 2. Technometrics: Vol. 16, No. 3, pp. 480-481.
A Fast Algorithm for Noise Smoothing Based on a Subjective Criterion (1977)

A simple and fast algorithm is presented to remove selectively random noise from an image while retaining visual resolution.
Design of an electro pneumatic micro robot for in-pipe inspection (2003)

The presentation of a micro robot for in-pipe inspection in 17 mm diameter pipes is detailed from the design to the implementation. A large part is dedicated to the modelling and estimation of each module. A completed modelling of a Hall effect sensor has been carried out in order to provide an accuracy of the displacement measurements better than 15 micrometers. Then the modelling and simulation of the whole robot have been compared to the implemented results. Finally, performances are discussed and perspectives are given to improve the locomotion task with the pneumatic actuator.
Highly enantioselective direct aldol reaction catalyzed by cinchona derived primary amines (2007)

Highly enantioselective aldol reactions of aldehydes with cyclic ketones catalyzed by a primary amine derived from cinchonine are reported. Aromatic aldehydes reacted with various cyclic ketones cleanly to afford the anti-aldol adducts in up to 99% yield, with good diastereoselectivities (up to 9 : 1) and excellent enantioselectivities (up to 99% ee).
The Life Script Heptagon (2022)

The life script heptagon, developed by the author, is described to show how seven elements, all seven aspects of human personality – behaviour, feelings, thoughts, body holding patterns, habits, beliefs and attitudes, and early decisions – fit together geometrically so that they reinforce and support each other and make it hard for people to change their life scripts. These elements are then related to the ways in which different psychotherapies tend to work with them, and explanations are given of why the geometric nature of the model means that several aspects need to change because otherwise the remaining elements are reinforcing the unhelpful patterns. Editorial Note: This is an example of the saying ‘great minds think alike’ – this version of a heptagon was being developed over several years and the author was unaware that Benedetti, Benelli and Zanchetta (2020) had been developing a similar geometrical shape with different elements. Benedetti et al. were also unaware that the version described in this article was being developed. (Benedetti et al article is in this journal, Vol. 11, Issue 1 at https://doi.org/10.29044/v11i1p13)
α <sub>1</sub> -Antitrypsin Portland, a bioengineered serpin highly selective for furin: Application as an antipathogenic agent (1998)

The important role of furin in the proteolytic activation of many pathogenic molecules has made this endoprotease a target for the development of potent and selective antiproteolytic agents. Here, we demonstrate the utility of the protein-based inhibitor alpha1-antitrypsin Portland (alpha1-PDX) as an antipathogenic agent that can be used prophylactically to block furin-dependent cell killing by Pseudomonas exotoxin A. Biochemical analysis of the specificity of a bacterially expressed His- and FLAG-tagged alpha1-PDX (alpha1-PDX/hf) revealed the selectivity of the alpha1-PDX/hf reactive site loop for furin (Ki, 600 pM) but not for other proprotein convertase family members or other unrelated endoproteases. Kinetic studies show that alpha1-PDX/hf inhibits furin by a slow tight-binding mechanism characteristic of serpin molecules and functions as a suicide substrate inhibitor. Once bound to furin's active site, alpha1-PDX/hf partitions with equal probability to undergo proteolysis by furin at the C-terminal side of the reactive center -Arg355-Ile-Pro-Arg358- downward arrow or to form a kinetically trapped SDS-stable complex with the enzyme. This partitioning between the complex-forming and proteolytic pathways contributes to the ability of alpha1-PDX/hf to differentially inhibit members of the proprotein convertase family. Finally, we propose a structural model of the alpha1-PDX-reactive site loop that explains the high degree of enzyme selectivity of this serpin and which can be used to generate small molecule furin inhibitors.
Mechanism of Curie-Point Writing in Thin Films of Manganese Bismuth (1971)

This paper presents the first detailed calculation of the demagnetizing field using the measured temperature dependence of the magnetization of manganese bismuth films and assuming realistic time-dependent temperature distributions. It yields calculated demagnetizing fields that are in good agreement with the measured values of field required to erase written spots in manganese bismuth in either of its two phases. Based on the agreement between measured erasure field and calculated demagnetizing field, we conclude that the demagnetizing field model of Curie-point writing is justifiable. The results can be used to explain the previously reported partial erasure characteristics of this material.
Belt Thresher with Adjustable Threshing Action (1986)

ABSTRACT Avertical belt thresher was designed, constructed, and tested. Threshing aggressiveness between the textured belt surfaces was varied by adjusting the speed difference and/or the contact pressure or spacing between the two belts. Belts of three different textures were also interchangeable. Threshing tests were run on legume and grass seed crops, individual flower seeds and heads, and vegetable seed heads. Threshing aggressiveness increased with increasing speed differences and contact pressures. The optimal belt surface was determined by trial runs with the desired product. The self-cleaning unit required only 1.2 m^ of floor space.
Temporal secondary access opportunities for WLAN in radar bands (2011)

Abstract—In this paper we quantify the temporal opportunities for secondary access in radar bands. Secondary users are assumed to be WLANs which opportunistically access the radar spectrum. Each WLAN device employs dynamic frequency selec-tion (DFS) as a mechanism to protect the radar from interference. We also consider an advanced interference protection mechanism, which is termed temporal DFS. It exploits the temporal variation of interference power due to the rotation of radar antenna. It is observed that the probability of accessing the radar band is significantly higher when the temporal DFS is used compared to the conventional DFS. As a consequence, more WLANs utilize the radar spectrum when the temporal DFS mechanism is considered. This shows that having better knowledge of the primary user activity can bring about the increased opportunity of secondary spectrum access, and thus improve the spectrum utilization. Index Terms—Secondary spectrum access, radar spectrum, aggregate interference, temporal opportunity, temporal DFS. I.
Cannabis, 21. Biotransformation of Cannabinol to Its Glycosides by In Vitro Plant Tissue (1993)

A marijuana compound, cannabinol [1], was converted to two metabolites using in vitro tissue of Pinellia ternata. The structures of the metabolites were determined to be cannabinol-O-beta-D-glucopyranoside [2] and 9'-hydroxycannabinol-O-beta-D-glucopyranoside [3] by 1H nmr and 13C nmr. From the time course experiments, 1 was absorbed rapidly in the tissues and glycosylated. Hydroxylation at the pentyl group occurred, and its metabolite was secreted in the medium.
Wide-band multiferroic quartz MEMS antennae (2019)

Abstract We describe a pair of quartz MEMS resonators integrated into a single vacuum package for use as a wide-band RF receiver. The resonators are connected to integrated sustaining circuits for oscillator operation and are used within a phase lock loop in which one oscillator is used as the reference. The other resonator is coated with a magnetostrictive layer which induces a frequency shift proportional to an applied external magnetic field. This frequency shift is detected by the phase lock loop and its feedback signal to a voltage controlled oscillator circuit is used as the antenna output. Thus, the bandwidth of the antenna is determined by the bandwidth of the phase lock loop and not the Q of the resonator.
Compiler optimizations for improving data locality (1994)

In the past decade, processor speed has become significantly faster than memory speed. Small, fast cache memories are designed to overcome this discrepancy, but they are only effective when programs exhibit data locality. In this paper, we present compiler optimizations to improve data locality based on a simple yet accurate cost model. The model computes both temporal and spatial reuse of cache lines to find desirable loop organizations. The cost model drives the application of compound transformations consisting of loop permutation, loop fusion, loop distribution, and loop reversal. We demonstrate that these program transformations are useful for optimizing many programs.
Multilayer feature combination for visual tracking (2015)

This paper proposes a new tracking method based on multilayer feature combination. In each layer, the target is segmented into local patches, and patch sizes of different layers are different. Through this way, each layer contains different local information of the object, which are mutually complementary for each other. For each layer, the local patches are represented with sparse codes. We combine these sparse codes into a histogram of sparse codes (HSC) for each layer. To handle appearance variations, we improve the HSC and obtain a modified histogram of sparse codes (MHSC), which is used to represent each layer. We combine the MHSCs of multilayer to form the feature vector of the object. To improve the robustness of the feature vector, different weights are assigned to various layers because each layer has different discriminative power under different cases. Within Bayesian framework, we achieve visual tracking by finding the candidate which has the highest similarity with the reference. Experiments demonstrate that the proposed method outperforms several state-of-the-art trackers.
New trends in lung preservation: a collective review. (1992)

Since the last review on lung preservation in 1985, enormous progress has been made in experimental and clinical lung transplantation. This comprehensive review examines recent advances in the experimental laboratory in optimizing conditions during organ procurement, lung storage, and reperfusion to minimize ischemia-reperfusion injury in lung allografts.
Effect of surface structural modification on absorptivity of gold in multi-pulse femtosecond laser ablation (2006)

Surface relief topography and surface absorptivity enhancement of a bulk gold sample following multi-pulse femtosecond laser ablation are studied. Peculiarities of the nano-structured surface absorptivity enhancement are explained as a result of both multiple light reflections on produced ramified gold surface and resonant light absorption by coupled nanostructures (wires, spheres, cones).