gebhart/patrepeval huggingface dataset:
A palette-driven approach to image color transfer (2005)

Color analysis of images for the purpose of color balancing, color contrast, and color correction is critical in image processing applications. Color analysis of images for the purpose of palette extraction has received less attention. Motivated by the question of how best to transfer color between two non-photorealistic images in such a way that artistic intent and image aesthetics are taken into consideration, we consider a palette driven approach to the image color transfer problem. Our goal is the transfer of chromatic content from a source image to a destination image with careful consideration given to value structure and artistic intent. We show examples of color transfers using our methods.
Large room-temperature effects from resonant tunneling through AlAs barriers (1986)

At room temperature, we have observed negative differential resistance in AlAs double-barrier structures and a large hysteresis in the current-voltage characteristic of a stack of five AlAs double-barrier structures. The peak-to-valley ratio of the current was as high as 3.5:1 in a double-barrier structure. To the best of our knowledge, this is the largest room-temperature peak-to-valley ratio observed to date in a double-barrier structure and the first report of a room-temperature hysteresis in a stacked structure. These structures were grown by molecular beam epitaxy using thin AlAs barriers in GaAs. Both the first and second resonances were observed, and are well explained by simple tunneling theory assuming a value of 1.0±0.1 eV for the GaAs-AlAs conduction-band discontinuity seen by the tunneling electrons. This value is very close to the difference in conduction-band energy at the Γ points found by using the accepted values of GaAs and AlAs band gaps with 65% of the band-gap difference appearing in the conduction band. This suggests that negligibly few electrons relax to the lower AlAs X valley as they tunnel through the 1.5–2.5-nm-thick AlAs barriers. These results indicate that AlAs should be a high quality barrier material for a variety of heterojunction devices.
The proteasome inhibitor bortezomib inhibits the release of NFkappaB-inducible cytokines and induces apoptosis of activated T cells from rheumatoid arthritis patients. (2009)

Proteasome inhibitors represented by bortezomib may elicit potential anti-inflammatory properties that deserve further exploration in experimental therapies for RA.
One-Step Synthesis and Characterization of Polyaniline Nanofiber/Silver Nanoparticle Composite Networks as Antibacterial Agents (2014)

Through a facile and effective seeding polymerization reaction via a one-step redox/complexation process, which took place in aqueous medium at ambient temperature, silver nanoparticles (Ag NPs) embedded polyaniline nanofiber (PANI NF) networks were synthesized as antibacterial agents. During the reaction, not only NF morphology formation of the resulting conducting polymers (CPs) but also amplification of the aqueous silver nitrate (AgNO3) solutions' oxidative potentials were managed by vanadium pentoxide (V2O5) sol-gel nanofibers, which acted as well-known nanofibrous seeding agents and the auxiliary oxidative agent at the same time. The PANI/Ag nanocomposites were proven to exhibit excellent antibacterial property against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. Antibacterial property performance and average life span of the nanocomposite network were optimized through the homogeneous distribution/embedment of Ag NPs within one-dimensional (1-D) PANI NF matrix. The antibacterial efficacy tests and nanocomposite material characterization results further indicated that the sole components of PANI/Ag have a synergistic effect to each other in terms of antibacterial property. Thus, this well-known catalytic seeding approach via a one-step oxidative polymerization reaction can be considered as a general methodology and a substantial fabrication tool to synthesize Ag NP decorated nanofibrillar PANI networks as advanced antibacterial agents.
Cobalt‐Catalyzed Vinylation of Functionalized Aryl Halides with Vinyl Acetates (2005)

Abstract A new method for the preparation of styrene derivatives is described on the basis of the activation of aryl halides by low‐valent cobalt species. A combination of Co II bromide and 2,2′‐bipyridine is suitable as catalyst for the cross‐coupling reaction of a wide range of aromatic halides (X = Cl, Br, I), mostly bearing sensitive moieties, with vinyl acetates. These reactions proceed under mild conditions in the presence of the appropriate reducing agent to afford α‐substituted styrene compounds in satisfactory to high yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Methylenetetrahydrofolate reductase thermolabile variant and oral clefts (1999)

Folic acid can prevent neural tube defects; in some cases the mechanism is probably a correction of a metabolic defect caused by thermolabile methylenetetrahydrofolate reductase (MTHFR) found in increased frequency in cases. It is less clear whether folic acid can prevent oral clefts, in part because it is not known whether thermolabile MTHFR is more common in those with oral clefts. This study examined the prevalence of the mutation (677 C→T) that causes thermolabile MTHFR in subjects with oral clefts from a national Irish support group, and an anonymous control group randomly selected from a neonatal screening program covering all births in Ireland. Eighty-three of 848 control subjects were homozygous (TT) thermolabile MTHFR (9.8%). This defect was almost three times as common in the 27 subjects (25.9%) with isolated cleft palate (odds ratio 3.23, 95% confidence interval 1.32 –7.86, P = 0.02) and somewhat more common in the 66 subjects with cleft lip with or without cleft palate (15.2%, odds ratio 1.65, 95% confidence interval 0.81–3.35, P = 0.20). When the two groups with different etiologies were combined, the overall odds ratio was 2.06 (95% confidence interval 1.16–3.66, P = 0.02). In the Irish population homozygosity for the common folate-related polymorphism associated with thermolabile MTHFR is significantly more frequent in those with isolated cleft palate, and could be etiologically important. Am. J. Med. Genet. 86:71–74, 1999. Published 1999 Wiley-Liss, Inc.
Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src (2009)

Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CAM1 [CEACAM1]) mediates homophilic cell adhesion and regulates signaling. Although there is evidence that CEACAM1 binds and activates SHP-1, SHP-2, and c-Src, knowledge about the mechanism of transmembrane signaling is lacking. To analyze the regulation of SHP-1/SHP-2/c-Src binding, we expressed various CFP/YFP-tagged CEACAM1 isoforms in epithelial cells. The supramolecular organization of CEACAM1 was examined by cross-linking, coclustering, coimmunoprecipitation, and fluorescence resonance energy transfer. SHP-1/SHP-2/c-Src binding was monitored by coimmunoprecipitation and phosphotyrosine-induced recruitment to CEACAM1-L in cellular monolayers. We find that trans-homophilic CEACAM1 binding induces cis-dimerization by an allosteric mechanism transmitted by the N-terminal immunoglobulin-like domain. The balance of SHP-2 and c-Src binding is dependent on the monomer/dimer equilibrium of CEACAM1-L and is regulated by trans-binding, whereas SHP-1 does not bind under physiological conditions. CEACAM1-L homodimer formation is reduced by coexpression of CEACAM1-S and modulated by antibody ligation. These data suggest that transmembrane signaling by CEACAM1 operates by alteration of the monomer/dimer equilibrium, which leads to changes in the SHP-2/c-Src-binding ratio.
Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF- B (2003)

Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are frequently overexpressed in tumor tissues or transformed cells. In the present work, we assessed the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of iNOS and COX-2 in mouse skin. Topical application to the dorsal skin of female ICR mice of 10 nmol TPA led to maximal induction of iNOS and COX-2 protein expression at approximately 2 and 4 h, respectively. When applied topically onto shaven backs of mice 30 min prior to TPA, the NOS inhibitor aminoguanidine (AG) inhibited the expression of COX-2 protein at the pharmacologically effective dose. Pretreatment with a more specific iNOS inhibitor, N(G)-nitro-l-arginine-methyl ester, also suppressed TPA-induced COX-2 expression. Immunohistochemical analysis of TPA-treated mouse skin using an anti-nitrotyrosine antibody reveals enhanced levels of nitrotyrosine protein localized in epidermal and dermal layers. Topical application of NO donors, such as sodium nitroprusside (SNP) and S-nitroso-N-acetyl-d,l-penicillamine, induced expression of COX-2 in mouse skin, which was attenuated by the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethyl imidazoline-1-oxyl 3-oxide. SNP treatment stimulated NF-kappaB activation in mouse skin, which was associated with the degradation of IkappaBalpha. Topical application of inhibitors of NF-kappaB, such as pyrrolidine dithiocarbamate or N-alpha-p-tosyl-l-lysine chloromethylketone, inhibited the SNP-induced COX-2 expression. SNP induced a weak but concentration-related increase in COX-2 expression in cultured mouse keratinocytes, which was abolished by treatment with SN50, a specific inhibitor of nuclear translocation of NF-kappaB. Mouse keratinocytes treated with SNP exhibited an elevated NF-kappaB-driven COX-2 promoter activity. Topical application of AG (10 micro mol) prior to each TPA treatment after initiation reduced the multiplicity of papillomas by 44% at 22 weeks. In conclusion, up-regulation of COX-2 by NO may be mediated by activation of NF-kappaB in mouse skin, which provides a molecular mechanism by which COX-2 is induced during tumor promotion.
Analytical study of ride smoothing benefits of control system configurations optimized for pilot handling qualities (1978)

An analytical study was conducted to evaluate the relative improvements in aircraft ride qualities that resulted from utilizing several control law configurations that were optimized for pilot handling qualities only. The airplane configuration used was an executive jet transport in the approach configuration. The control law configurations included the basic system, a rate feedback system, three command augmentation systems (rate command, attitude command, and rate command/attitude hold), and a control wheel steering system. Both the longitudinal and lateral directional axes were evaluated. A representative example of each control law configuration was optimized for pilot handling qualities on a fixed base simulator. The root mean square airplane responses to turbulence were calculated, and predictions of ride quality ratings were computed by using three models available in the literature.
A Robust Illumination Estimate for Chromatic Adaptation in Rendered Images (2009)

Abstract We propose a method that improves automatic colour correction operations for rendered images. In particular, we propose a robust technique for estimating the visible and pertinent illumination in a given scene. We do this at very low computational cost by mostly re‐using information that is already being computed during the image synthesis process. Conventional illuminant estimations either operate only on 2D image data, or, if they do go beyond pure image analysis, only use information on the luminaires found in the scene. The latter is usually done with little or no regard for how the light sources actually affect the part of the scene that is being viewed. Our technique goes beyond that, and also takes object reflectance into account, as well as the incident light that is actually responsible for the colour of the objects that one sees. It is therefore able to cope with difficult cases, such as scenes with mixed illuminants, complex scenes with many light sources of varying colour, or strongly coloured indirect illumination.
A practical and efficient method for compare-point matching (2002)

An important step in using combinational equivalence checkers to verify sequential designs is identifying and matching corresponding compare-points in the two sequential designs to be verified. Both non-function and function-based matching methods are usually employed in commercial verification tools. In this paper, we describe an heuristic algorithm using ATPG for matching compare-points based on the functionality of the combinational blocks in the sequential designs. Results on industrial-sized circuits show the methods are both practical and efficient.
An adaptive medium access control (MAC) protocol for reliable broadcast in wireless networks (2002)

This paper presents ABROAD, an adaptive medium access control (MAC) protocol for reliable broadcast packet transmission in wireless networks. ABROAD incorporates a collision-avoidance handshake within each slot of a synchronous transmission schedule, allowing nodes to reclaim and/or reuse idle slots while maintaining bounded access delay. Thus, ABROAD provides worst-case performance guarantees while remaining adaptive to local changes in traffic load and node connectivity. We analyze the optimal worst-case performance of ABROAD, and show that there is a strict increase in the number of broadcast packets per second over a pure time division multiple access (TDMA) protocol. Extensive simulation confirms our analysis, and also demonstrates that ABROAD outperforms broadcast protocols based on reliable unicast packet delivery schemes, such as the IEEE 802.11 MAC standard.
Amide Bond Formation and Peptide Coupling (2006)

Abstract For Abstract see ChemInform Abstract in Full Text.
Artificial iris–lens diaphragm in reconstructive surgery for aniridia and aphakia (2005)

Artificial iris-lens diaphragm implantation effectively improved postoperative outcomes by correcting aphakia, reducing glare disability, and addressing cosmetic issues faced by iris-deficient, and aphakic or cataract patients. Although the iris-lens diaphragm appears to be safe, long-term results must be clarified in studies with longer follow-up and a larger patient population.
Hormonal and Nutritional Control of the Fatty Acid Synthase Promoter in Transgenic Mice (1995)

To study the molecular basis of tissue-specific and hormonally regulated expression of the fatty acid synthase (FAS) gene in vivo, we generated lines of transgenic mice carrying 2.1 kilobases of the 5'-flanking region (-2100 to +67) of the rat FAS gene fused to a chloramphenicol acetyltransferase (CAT) reporter gene. This reporter gene construct was strongly expressed in tissues that normally express high levels of FAS mRNA, which include liver and white adipose tissues. In contrast, CAT reporter activity was not detected in appreciable levels in lung, heart, kidney, and muscle tissues, which do not normally show significant levels of FAS activity. The relative levels of the CAT mRNA driven by the rat FAS promoter in various tissues of the transgenic animals approximated those of the endogenous mouse FAS mRNA. We also examined the hormonal and nutritional regulation of the FAS(2.1)-CAT reporter gene in transgenic mice. CAT activity was increased in both liver and white adipose tissue when fasted animals were refed a high carbohydrate, fat-free diet. These changes in CAT activity and CAT mRNA levels occurred in parallel to the changes in endogenous mouse FAS mRNA levels. On the other hand, fasting/refeeding did not change CAT activity appreciably in other tissues, such as muscle and brown adipose tissue. Administration of dibutyryl cAMP at the start of refeeding prevented an increase in CAT activity in liver. However, the cAMP effect was tissue-specific as cAMP treatment did not bring about change in CAT activity in adipose tissue. Next, to examine the effect of insulin, we made the transgenic mice insulin-deficient by streptozotocin treatment. Insulin treatment of the streptozotocin-diabetic mice increased both the CAT activity and CAT mRNA levels driven by the rat FAS promoter in liver and white adipose tissue. These changes in CAT expression by insulin paralleled those in endogenous FAS mRNA levels. Administration of glucocorticoids increased CAT activity in all tissues examined: liver, white and brown adipose tissues, lung, heart, and spleen. Overall, the first 2.1 kilobases of the 5'-flanking region of the rat FAS gene appear to contain sequence elements necessary to confer tissue-specific and hormonally regulated expression characteristic of the endogenous FAS gene.
Press release : 2014 : 09 : 12 : New USFSP Grad Publishes Research in National Journal (2014)

For her senior honors thesis in 2013, Lauren Dellert began a research journey when she sought to discover
Mutant T7 RNA polymerase is capable of catalyzing DNA primer extension reaction (1998)

The mutant T7 RNA polymerase (T7 RNAP), containing two substitutions (Y639F, S641A) was earlier shown to utilize both rNTP and dNTP in a transcription-like reaction. In this report the ability of the enzyme to catalyze DNA primer extension reaction was demonstrated. The efficiency of the reaction essentially depended on the type of the primer sequence, and was significantly higher if the primer coincided with the T7 promoter non-coding sequence. In this case the primer extension reaction proceeded along with de novo RNA synthesis. The length of the product did not exceed 8 nucleotides, indicating that the primer extension reaction proceeds according to the mechanism of the T7 RNAP-catalyzed abortive transcription.
Amino Acid 226 in the Hemagglutinin of H9N2 Influenza Viruses Determines Cell Tropism and Replication in Human Airway Epithelial Cells (2007)

Influenza A viruses of the H9N2 subtype are endemic in poultry in many Eurasian countries and have occasionally caused clinical respiratory diseases in humans. While some avian H9N2 viruses have glutamine (Q) at amino acid position 226 of the hemagglutinin (HA) receptor-binding site, an increasing number of isolates have leucine (L) at this position, which has been associated with the establishment of stable lineages of the H2 and H3 subtypes of viruses in humans. Little is known about the importance of this molecular trait in the infection of H9N2 viruses in humans. We show here that during the course of a single cycle of infection in human airway epithelial (HAE) cells cultured in vitro, the L-226-containing H9N2 viruses displayed human virus-like cell tropisms (preferentially infecting nonciliated cells) different from the tropisms showed by Q-226-containing H9N2 isolates (which infect both ciliated and nonciliated cells at ratios of 1:1 to 3:2) or other waterfowl viruses (which preferentially infect ciliated cells). During multiple cycles of replication in HAE cultures, L-226-containing H9N2 isolates grew consistently more efficiently and reached approximately 100-fold-higher peak titers than those containing Q-226, although peak titers were significantly lower than those induced by human H3N2 viruses. Our results suggest that the variation in residue 226 in the HA affects both cell tropism and replication of H9N2 viruses in HAE cells and may have implications for the abilities of these viruses to infect humans.
Distinct functionalities of bone morphogenetic protein antagonists during fracture healing in mice (2010)

The bone morphogenetic protein (BMP) family of growth factors plays critical roles in bone formation. BMPs are regulated at multiple levels by various BMP antagonists. This study investigated how BMP antagonists are integrated into the cascade of events of bone formation during fracture healing. Forty mice underwent a controlled femur fracture; tissue samples at the fracture site were harvested at days 1, 3, 7, 14 and 21 after fracture, for quantification of the expression of BMPs and BMP antagonists. During fracture healing, BMP-2, -4 and -7 were up-regulated, but BMPR-1A and BMPR-2 showed reduced expression after day 14. Among BMP antagonists, the expressions of PRDC, SOST, Smad7, GREM1 and CERBERUS were generally down-regulated during fracture healing. In contrast, Noggin was significantly up-regulated in the first week after fracture; 7 days after fracture, other BMP antagonists, including DAN, CHRD, Smad6 and BAMBI, also showed significantly increased expression. In conclusion, this study indicates that BMP antagonists can be divided into two functional groups in relation to fracture healing: (1) those whose suppression may be essential for the initiation of osteogenesis; (2) those that are upregulated and may function in the remodeling of newly formed bone.
Thermal stability testing of GMR recording heads (1999)

A methodology and apparatus are described for studying the thermal stability and blocking temperature distribution of recording heads with GMR sensors. Results using sensors with FeMn, IrMn, and PtMn exchange layers show that GMR designs with PtMn show improved thermal stability. It is concluded that an MR curve tester with a temperature-controlled "hot finger" can provide valuable information on the relative thermal stability and blocking temperature distributions of GMR head designs.
Changes in Cell Wall Architecture of Differentiating Tracheids of Pinus thunbergii during Lignification (1999)

The cell wall architecture, before and after lignification, of differentiating tracheids in Pinus thunbergii has been examined using a rapid-freeze deep-etching technique combined with transmission electron microscopy. Replicas of cells from the cambial zone showed that the unlignified primary cell wall was highly porous with microfibrils extensively interconnected by crosslinks. The unlignified secondary cell wall has unidirectional microfibrils, more or less associated in bundles, forming a wavy pattern around pores of characteristic slit-like shape with narrowing ends. As the lignification progresses, the cell wall structure becomes dense, with no detectable pores. Delignification of wood samples leads to the reappearance of crosslinks, individual microfibrils and pores in the secondary cell wall, although in a somewhat altered shape. In addition, cellulose-synthesizing enzyme complexes (rosettes) have for the first time been detected on the plasma membrane of differentiating xylem cells of softwood.
Development and Optimization of a Catalytic Thruster for Hydrogen Peroxide Decomposition (2014)

Hydrogen peroxide is a non toxic, low cost, green monopropellant with a significant potential for applications in satellite microthrusters. It presents a density-specific impulse, similar to hydrazine. A new bulk mixed oxide catalyst for decomposition of hydrogen peroxide has been developed and tested in a 2 N thruster with modular parts, allowing the use of catalytic beds with different diameters and lengths. A method of experiment design with a star configuration was implemented to optimize the catalytic bed geometry, in order to yield complete peroxide decomposition, reduce thruster size and volume and provide maximum thrust.