gebhart/patrepeval huggingface dataset:
A comparative study of the promotion of tissue plasminogen activator and pro-urokinase-induced plasminogen activation by fragments D and E-2 of fibrin. (1991)

Plasmin generation by equimolar concentrations of tissue plasminogen activator (t-PA), pro-urokinase (pro-UK), and urokinase (UK), and a twofold higher concentration of a plasmin-resistant mutant rpro-UK (Ala-158-pro-UK) was measured on a microtiter plate reader. The promoting effects on this reaction of equimolar concentrations of fibrinogen, soluble fibrin (Desafib), CNBr fragment FCB-2 (an analogue of fragment D), or purified fragment E-2 were compared. Plasmin generation by t-PA was moderately promoted by fibrinogen, substantially promoted by Desafib and FCB-2, but not at all promoted by fragment E-2. By contrast, plasmin generation by pro-UK or by Ala-158-pro-UK was not promoted either by fibrinogen, Desafib, or FCB-2, but was significantly promoted by fragment E-2. Plasmin generation by UK was not significantly promoted by any of the fibrin(ogen) preparations. Treatment of fragment E-2 by carboxypeptidase-B (CPB), eliminated its promotion of pro-UK and Ala-158-pro-UK-induced plasmin generation. Pretreatment of FCB-2 with plasmin slightly potentiated its promotion of t-PA activity. This effect of plasmin pretreatment of FCB-2 was reversed by CPB treatment. Plasmin pretreatment of FCB-2 did not induce any promotion of activity in pro-UK or Ala-158-pro-UK. The findings show that the intrinsic activity of pro-UK and the activity of t-PA are promoted by different regions of the fibrin(ogen) molecule. The latter is stimulated primarily by a determinant in the fragment D region, which is available in intact fibrin. By contrast, plasminogen activation by the intrinsic activity of pro-UK was stimulated exclusively by fragment E-2, which is unavailable in intact fibrin. The findings are believed relevant to fibrinolysis and support the concept that t-PA and pro-UK are complementary, sequential, and synergistic in their actions.
Industrialisation of Resurf Stepped Oxide Technology for Power Transistors (2006)

The interaction of fabrication processes and device performance in RSO (resurf stepped oxide) transistors is explored in this paper. Critical process steps for achieving good control of resurf behaviour are the etching of the deep trenches, their refill with thick oxide and etch-back to define the oxide step. Optimum conditions result in typical Rspec of 46mOmega.mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at a BVdss of 80V and defect densities less than 3 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> . Qgd values of about 9 nC/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2 </sup> limit the single-gate polysilicon RSO structure to low frequency applications, such as switching automotive loads. Simulation has indicated that the introduction of a split-polysilicon RSO structure, with source-connected bottom poly, gives excellent Rds.Qgd values, which are an order of magnitude lower, hence extending the scope of the technology to high frequency applications
Measuring surface wave propagation during vibrotactile stimulation (2012)

The objective of the present set of experiments was to characterize the properties of travelling waves induced by vibrotactile stimulation of the skin and to determine whether these varied significantly at three different locations on the body: the palm of the hand, the forearm and the thigh. These locations are often considered for use in tactile displays used for spatial cuing. A custom designed flexible printed circuit board containing an array of accelerometers was fabricated for this purpose. The results indicated that there was a marked decrease in the frequency of vibration when measured on a compliant surface such as the skin as compared to a rigid fixture and that the magnitude of this decrease varied significantly among the sites tested. The surface wave elicited by the vibrating motor on the skin was markedly attenuated by 8 mm on all the sites tested but was still measurable at 24 mm, suggesting that for the type of motor tested the spacing between motors in a display should exceed 24 mm if precise spatial localization is required. There were differences between the glabrous and hairy skin in terms of the frequency and amplitude measured for the same mechanical input. These findings suggest that it is important to take into consideration the mechanical properties of the skin when designing tactile displays as these will affect the responses of cutaneous mechanoreceptors.
Anodic detection in flow-through cells (1986)

Virtually all organic compounds and numerous inorganic compounds are predicted from thermodynamics to be oxidized at potentials accessible at commonly used solid electrodes in aqueous media by reactions which require transfer of oxygen from H2O to the oxidation products. These anodic reactions are usually kinetically inhibited because of their complexity. Progress is summarized to develop electrocatalytic processes for anodic detection in flowing aqueous solutions.Pulsed amperometric detection at Pt electrodes is applicable for the sensitive detection of the HCOH group in all alcohols, polyalcohols and carbohydrates, the nitrogen in amines, amino acids and aminoglycosides, and sulphur in most inorganic and organic compounds. Pure and doped lead dioxide electrodes are described for amperometric detection at constant potential.The voltammetric response of electrocatalysed oxygen-transfer reactions is dictated by the potential dependence of the process transferring oxygen from H2O to the electrode surface, so that attempts at voltammetric resolution of mixtures are not generally effective. The most useful analytical application of the electrocatalysed processes for mixtures is in the form of amperometric detection in liquid-chromatographic systems.
Salvage operations for malfunctioning polytetrafluoroethylene hemodialysis access grafts. (1983)

During the study period a cohort of 170 of patients receiving long-term hemodialysis treatment required placement of 214 polytetrafluoroethylene grafts for vascular access; within this period 74 of these patients had significant graft malfunction that required 149 salvage operations. The most common failure/malfunction was thrombosis, and the most commonly appreciated mechanical cause of graft failure was outflow venous stenosis. Complex revisions were required to address this problem. First, second, and third revisions were successful in 65%, 53%, and 44% of cases, respectively. Multiple revisions, including thrombectomy, were required in some, but the functional life of these salvaged grafts was nearly equal to that of grafts that did not require revision. Abandonment of grafts because of secondary infection exacted a toll in both groups.
Human Factor H Interacts Selectively with <i>Neisseria gonorrhoeae</i> and Results in Species-Specific Complement Evasion (2008)

Complement forms a key arm of innate immune defenses against gonococcal infection. Sialylation of gonococcal lipo-oligosaccharide, or expression of porin 1A (Por1A) protein, enables Neisseria gonorrhoeae to bind the alternative pathway complement inhibitor, factor H (fH), and evade killing by human complement. Using recombinant fH fragment-murine Fc fusion proteins, we localized two N. gonorrhoeae Por1A-binding regions in fH: one in complement control protein domain 6, the other in complement control proteins 18-20. The latter is similar to that reported previously for sialylated Por1B gonococci. Upon incubation with human serum, Por1A and sialylated Por1B strains bound full-length human fH (HufH) and fH-related protein 1. In addition, Por1A strains bound fH-like protein 1 weakly. Only HufH, but not fH from other primates, bound directly to gonococci. Consistent with direct HufH binding, unsialylated Por1A gonococci resisted killing only by human complement, but not complement from other primates, rodents or lagomorphs; adding HufH to these heterologous sera restored serum resistance. Lipo-oligosaccharide sialylation of N. gonorrhoeae resulted in classical pathway regulation as evidenced by decreased C4 binding in human, chimpanzee, and rhesus serum but was accompanied by serum resistance only in human and chimpanzee serum. Direct-binding specificity of HufH only to gonococci that prevents serum killing is restricted to humans and may in part explain species-specific restriction of natural gonococcal infection. Our findings may help to improve animal models for gonorrhea while also having implications in the choice of complement sources to evaluate neisserial vaccine candidates.
High-power quantum-dot lasers at 1100 nm (2000)

High-power semiconductor laser diodes based on multiple InGaAs/GaAs quantum-dot layers grown by metal–organic chemical-vapor deposition are demonstrated. The devices exhibit a peak power of 3 W (4.5 W) at 1100 nm (1068 nm), respectively, during pulsed operation at room temperature and show slope efficiencies of 57% (66%).
1,4-Reduction of an α,β-Unsaturated Ketone by Lithium Aluminum Hydride<sup>1</sup> (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,4-Reduction of an α,β-Unsaturated Ketone by Lithium Aluminum Hydride1Robert E. Lutz and David F. HinkleyCite this: J. Am. Chem. Soc. 1950, 72, 9, 4091–4092Publication Date (Print):September 1, 1950Publication History Published online1 May 2002Published inissue 1 September 1950https://pubs.acs.org/doi/10.1021/ja01165a070https://doi.org/10.1021/ja01165a070research-articleACS PublicationsRequest reuse permissionsArticle Views409Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A vector fetal magnetocardiogram system with high sensitivity (1999)

The vector fetal magnetocardiogram (V-FMCG) system that measures the three orthogonal components of the magnetic field from a fetal heart has been developed to clearly observe fetal cardiac activity during pregnancy by using the superconducting quantum interference device. To detect a clear V-FMCG signal, the bottom of the cryostat was made of thin glass–fiber-reinforced plastic and the total length between the pickup coil to the outer surface is 12 mm. Because the cryostat bottom was made thinner, the area of the cryostat’s top and bottom could be made smaller, thus a low evaporation loss (&lt;1.2 l per day) and a long refilling interval (&gt;10 days) were obtained. The gantry was able to tilt the cryostat and the bed could move in three axis directions, which made it possible to easily locate the vector pickup coil at an optimum position to obtain the maximum magnetic field from a fetal heart. We obtained V-FMCGs from 21 normal fetuses with gestation periods of 27–38 weeks. Using these vector signals, the dipoles were estimated and the relationship between the strength of the dipole moments and the number of gestation weeks could be obtained. Thus, V-FMCG seems to represent a new noninvasive tool for clearly detecting the electrophysiological activity of a fetal heart.
Simplified kilogram traceability for high-power laser measurement using photon momentum radiometers (2020)

Photon momentum radiometers measure the force imparted by a reflected laser beam to determine the laser's optical power. This requires high-accuracy calibration of the force sensors using milligram and microgram mass artifacts. Calibrated test masses can therefore be used to provide traceability of these radiometers to the International System of Units, but low-noise calibration at these mass levels is difficult. Here, we present the improvement in calibration capability that we have gained from implementing a robotic mass delivery system. We quantify this in terms of the specific nuances of force measurements as implemented for laser power metrology.
Inhibition of MHC class II-restricted T cell response by Lyt-2 alloantigen. (1989)

T cell hybridomas were established by fusing a CD8+ V beta 8.1+ CTL clone and a CD4+ V beta 8.1+ helper T lymphocyte (HTL) clone to the thymoma cell line BW5147. In contrast to the HTL x BW hybridomas, which retain the same antigen specificity as the original T cell clone, the CTL x BW hybridomas lost the class I MHC-restricted antigen response but acquired a new specificity to Mlsa antigen. Mlsa reactivity of CTL x BW hybridomas was shown to be mediated by the CTL TCR as assayed by inhibition using an anticlonotypic antibody to the CTL clone. Since hybridomas established with BW5147 lose CD8 expression, we have introduced the CD8 molecule into CTL x BW5147 hybridomas by gene transfection. The CD8+ V beta 8.1+ hybridoma was no longer capable of reacting to Mlsa antigen but exhibited the same antigen specificity as the parental CTL clone. Furthermore, the presence of the transfected CD8 molecule in the HTL x BW hybridomas was found to be inhibitory to class II MHC-restricted antigen reactivity. These results demonstrate that, besides its role in increasing the overall avidity of T cell-class I MHC/antigen interaction, the CD8 molecule inhibits T cell-class II MHC gene product/antigen interaction. This negative effect of the CD8 molecule on a class II MHC-restricted response may account for the failure of CD8+ T cells using either V beta 8.1 or V beta 6, which impart reactivity to the Mlsa antigen on CD4+ T cells, to respond to the Mlsa antigen.
Monitoring of bacterial drug response by mass spectrometry of single cells (1988)

The application of the laser microprobe mass analyser LAMMA 500 to the solution of problems in the field of microbiology is reported. The special features of this instrument allow the analysis of single bacterial cells, and questions can be answered which are not accessible to the normally applied integral methods. Thus it is possible to establish distributions of, for instance, elemental concentrations within a bacterial population and of correlations between measured characteristics of a bacterium with its morphology. The mass spectrum of a single bacterial cell comprises information on its intracellular cation contents as well as on the organic matrix. The relation between the sodium and potassium contents can serve as a criterion of the physiological state of a cell and of its viability. The information from the organic matrix can be extracted from the complex spectra of fragment ions produced by the interaction of the laser with the cell by applying multivariate data analysis, thus rendering additional information. Examples will be given for in vitro drug screening and in vivo therapy control in leprosy, an infection which is caused by a mycobacterial species, Mycobacterium leprae; this organism does not multiply in artificial growth media so that only limited numbers of organisms are available for microbiological investigations.
Experiments in imitation using perceptuo-motor primitives (2000)

No abstract available.
On-chip boost regulator with projected off- and on-time control (2009)

The boost type power supplies are widely used in portable consumer electronics to step up the input voltage to adapt for the high voltage applications like light-emitting diode (LED) driving and liquid crystal display (LCD) biasing. In these applications, a regulator with small volume, fewer external components and high efficiency is highly desired. This paper proposes a projected off- and on-time boost control scheme, based on which a monolithic IC with an on-chip VDMOS with 0.2 Ω on-state resistance R DS-ON was implemented in 1.5 μm bipolar-CMOS-DMOS (BCD) process. A 12 V, 0.3 A boost regulator prototype is presented as well. With projected off-time and modulated on-time in continuous conduction mode (CCM), a quasi fixed frequency, which is preferred for ripple control, is realized. With projected on-time and modulated off-time in discontinuous conduction mode (DCM), pulse frequency modulation (PFM) operation, which is beneficial to light load efficiency improvement, is achieved without extra control circuitry. Measurement results show that an efficiency of 3% higher than that of a conventional method under 0.5 W output is achieved while a step load transient response comparable to that of current mode control is maintained as well.
A Reprogamming Protocol Based on State Machine for Wireless Sensor Network (2010)

In order to solve the problem that program-code of the sensor node in wireless sensor network was difficult to upgrade, the application layer protocol OTA-WSN was presented. With reference to the OTA Technology applied in mobile network, this paper defined the functions of each communication sector in the protocol, including package's format of the application layer packages and data transfer protocol it used. It also putted forward the framework of the protocol and the theoretical model of state-machine. This protocol had been realized on a wireless sensor network platform called Mica2. The experiment result shows that this protocol not only improves feasibility and reliability of the wireless sensor network but also incarnates the efficiency for development of the WSN system.
MULTI-MEDIA PROJECTOR - SINGLE CAMERA PHOTOGRAMMETRIC SYSTEM FOR FAST 3D RECONSTRUCTION (2010)

Some of the important technical characteristics of photogrammetric system are the speed of 3D acquisition, automation and possibility for smart operating. Using structured and coded light allows to solve correspondence problem fast, robustly and accurate. And applying of PC-controlled structured light provides a possibility to make a step to highly automated and intellectual photogrammetric systems. Multi-media projectors have a number of features which make them attractive for using in photogrammetric application. The main of these features are high technical characteristics (such as brightness, contrast, signal/noise ratio, resolution) and a reasonable price. And the main advantage of digital projector is a capability of smart lighting for applying smart processing algorithms. A traditional configuration of a close range photogrammetric system usually includes two calibrated cameras and a structured light projector, which has no need to be calibrated. If color texturing is needed additional color camera is applied. Using PC-controlled multi-media calibrated projector allows to increase productivity of a 3D reconstruction system and to reduce its cost due to including only one monochrome camera. Techniques for projector calibration and for 3D model color texturing are developed. Projector calibration is based on standard bundle adjustment technique traditionally used for camera calibration. The first approach uses two calibrated cameras for producing “virtual ” spatial test field. The second method supposes generating synthetic “images ” of a test field observed by the projector. Then the parameters of interior orientation for the camera and the projector are found by standard bundle adjustment procedure. 3D model color texturing performed by a set of monochrome images processing obtained in projector lighting. 1.
Algorithm of Fingertip Detection and Its Improvement Based on Kinect (2017)

Fingertip feature is the most important feature of gesture recognition, and fingertip detection is the core of the interactive system. Because of high requirement of fingertip information for video gesture recognition technology, a method of fingertip detection is proposed based on information of depth image and human skeleton. Firstly, the Kinect is chosen to carry out the collection of the depth image, then the hand is positioned, the image is preprocessed, the eight neighborhood tracking algorithm and a series of other algorithms are used to split the gestures. Then the shortcomings of traditional K-curvature fingertip detection algorithm are analyzed, and it combines with fast convex hull algorithm for fingertip recognition. Finally, an algorithm called "scan fitting method" is proposed to solve the problem of fingertip close detection.
Studies on the Purine-sensitive Mutants of Bacillus Subtilis (1969)

Journal Article Studies on the Purine-sensitive Mutants of Bacillus Subtilis: 1. Properties of an Adenosine-sensitive Mutant Get access MAKOTO KIDA, MAKOTO KIDA From the Microbiological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar FUMIKO KAWASHIMA, FUMIKO KAWASHIMA From the Microbiological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar AKIRA IMADA, AKIRA IMADA From the Microbiological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar IKUO NOGAMI, IKUO NOGAMI From the Microbiological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar IKUO SUHARA, IKUO SUHARA From the Microbiological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar MASHIKO YONEDA MASHIKO YONEDA From the Microbiological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 66, Issue 4, October 1969, Pages 487–492, https://doi.org/10.1093/oxfordjournals.jbchem.a129173 Published: 01 October 1969 Article history Received: 10 March 1969 Published: 01 October 1969
Implementation of dynamically autoconfigured multiservice multipoint VPN (2015)

Nowadays the use of enterprise VPN services is integrated in every larger company. SOHO and SMB also use VPN for connection with Internet providers, VoIP, banking transactions. Our approach suggests to automatize building and using multicomponent VPN topologies. We also proposed the cloud to build full-mesh dynamic multipoint VPNs based on routers using scripts.
Effect of Cladding Material on 2-eV Optical Absorption in Pure-Silica Core Fibers and Method to Suppress the Absorption (1987)

The growth of 2-eV optical absorption induced by γ-ray irradiation is larger in pure-silica core fibers with a dopedglass cladding than in the fibers with a silicone cladding, regardless of the manufacturing process. Precursors of nonbridging oxygen hole centers which abundantly exist at the core/cladding interface of the glass-cladding fibers are responsible for the difference in the absorption. A combined-treatment of hydrogen and γ-ray irradiation can remove these precursors and suppress the absorption.