Gene Therapy in Humans: A New Era Begins (1991)

Editorials15 April 1991Gene Therapy in Humans: A New Era BeginsWilliam N. Kelley, MDWilliam N. Kelley, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-8-697 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRemarkable advances have occurred in the field of molecular biology in the last 30 years. Our understanding of pathophysiologic processes and their relationship to gene structure, function, and control has grown impressively. Indeed, the new biology has matured to the point where its applications to the practice of medicine are increasingly apparent. Recombinant technology is now used not only for diagnostic purposes but also for the generation of naturally occurring biologic products that are currently available for patient care. For the last decade, increasing attention has focused on the possibility that genes could be inserted into somatic cells to correct...References1. Kantoff P, Gillio A, and McLachlin J. Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer. J Exp Med. 1987;166:219-34. CrossrefMedlineGoogle Scholar2. St. Louis D and Verma I. An alternative approach to somatic cell gene therapy. Proc Natl Acad Sci USA. 1988;85:3150-4. CrossrefMedlineGoogle Scholar3. Morgan J, Barrandon Y, Green H, and Mulligan R. Expression of an exogenous growth hormone gene by transplantable human epidermal cells. Science. 1987;237:1476-9. CrossrefMedlineGoogle Scholar4. Wilson J, Chowdhury N, and Grossman M. Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes. Proc Natl Acad Sci USA. 1990;87:8437-41. CrossrefMedlineGoogle Scholar5. Nabel E, Plautz G, Boyce F, Stanley J, and Nabel G. Recombinant gene expression in vivo within endothelial cells of the arterial wall. Science. 1989;244:1342-4. CrossrefMedlineGoogle Scholar6. Drumm M, Pope H, and Cliff W. Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer. Cell. 1990;62:1227-33. CrossrefMedlineGoogle Scholar7. Palella T, Hidaka Y, Silverman L, Levine M, Glorioso J, and Kelley W. Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector. Gene. 1989;80:137-44. CrossrefMedlineGoogle Scholar8. Nabel E, Plautz G, and Nabel G. Site-specific gene expression in vivo by direct gene transfer into the arterial wall. Science. 1990;249:1285-8. CrossrefMedlineGoogle Scholar9. Wu C, Wilson J, and Wu G. Targeting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo. J Biol Chem. 1989;264:16985-7. CrossrefMedlineGoogle Scholar10. Wolff J, Malone R, and Williams P. Direct gene transfer into mouse muscle in vivo. Science. 1990;247:1465-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: William N. Kelley, MDAffiliations: University of Pennsylvania Medical Center Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1991Volume 114, Issue 8Page: 697-698KeywordsBiologicsCellsGene therapyMolecular biologyPatients ePublished: 1 December 2008 Issue Published: 15 April 1991 PDF downloadLoading ...