gebhart/patrepeval huggingface dataset:
Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type–Specific Dynamic Logic Models (2017)

Genomic features are used as biomarkers of sensitivity to kinase inhibitors used widely to treat human cancer, but effective patient stratification based on these principles remains limited in impact. Insofar as kinase inhibitors interfere with signaling dynamics, and, in turn, signaling dynamics affects inhibitor responses, we investigated associations in this study between cell-specific dynamic signaling pathways and drug sensitivity. Specifically, we measured 14 phosphoproteins under 43 different perturbed conditions (combinations of 5 stimuli and 7 inhibitors) in 14 colorectal cancer cell lines, building cell line-specific dynamic logic models of underlying signaling networks. Model parameters representing pathway dynamics were used as features to predict sensitivity to a panel of 27 drugs. Specific parameters of signaling dynamics correlated strongly with drug sensitivity for 14 of the drugs, 9 of which had no genomic biomarker. Following one of these associations, we validated a drug combination predicted to overcome resistance to MEK inhibitors by coblockade of GSK3, which was not found based on associations with genomic data. These results suggest that to better understand the cancer resistance and move toward personalized medicine, it is essential to consider signaling network dynamics that cannot be inferred from static genotypes. <i>Cancer Res; 77(12); 3364-75. ©2017 AACR</i>.
Self-Stimulation of the Brain (1958)

My conclusions are these: (i) The cells which mediate primary rewarding effects are located in a midline system running from the midbrain through the hypothalamus and midline thalamus and into the subcortical and cortical groups of the rhinencephalon. (ii) The cell groups which mediate primary rewarding effects are different from those which mediate primary punishing effects. (iii) Despite this relative independence, there are, undoubtedly, relationships of mutual inhibition existing between these two systems. Rewards do, among other things, tend to reduce sensitivity to pain, and punishments do tend to reduce rewarding effects. (iv) These primary reward systems of the brain are subdivided into specific drive-reward subsystems mediating the specific drives such as hunger and sex. (v) Because there are also subsystems of this set of rewarding structures sensitive to different chemical effects, it is reasonable to hope that eventually it will be possible to control the reward systems pharmacologically in cases where behavior disorders seem to result from deficits or surfeits of positive motivation.
Low cost AC power monitor for residential PV support (2003)

The rate at which new, residential on-grid PV systems are being installed increases every year. Yet, most include virtually no metering, customer education or other support for the system owners. The California Energy Commission's Renewable Energy Program Evaluation, October 2000, stated that consumers need a basic level of system performance measurement in order to verify whether their system is operating properly. This echoes a recurring observation that has been made by researchers, at least, since 1990. Consumers can turn to after-market meters which exist, but these are often inaccurate and none supports remote display. Of equal concern is that manufacturers of most meters assume a basic knowledge of electrical power that homeowners do not possess. To help meet this longstanding need, an inexpensive, accurate, AC power monitor has been developed for installation by an untrained homeowner. This monitor incorporates a power line carrier remote display that can be located anywhere in the home. The monitor and associated training materials have been designed to teach consumers to accurately assess PV system performance and recognize system failures. It is hoped that the unit's low cost and potential consumer value demonstrate its commercial viability.
A New Self-Aligned Framed Mask Method for Selective Oxidation (1981)

A new selective oxidation method, which realizes fine isolation width for MOS LSIs, has been developed. The oxidation mask in this method has a Si 3 N 4 frame formed at a perimeter of a conventional mask pattern by self-aligned technique. This technique is composed of deposition step of Si 3 N 4 film to cover the conventional mask and dry etching step of this film to form the frame without a photoresist pattern. Bird's beak extent is suppressed to less than 300 nm. Dislocation generation in silicon substrate is also suppressed in this framed mask method. Bird's beak suppression brings about extention in an effective device area and realizes a transistor with effective channel width 1.0 µm wider than that in the conventional mask method. The p-n junction prepared by this new method exhibits as small leakage current as that by the conventional method.
Prophylactic Mastectomy and Reconstruction: Clinical Outcomes and Patient Satisfaction (2008)

Background: The purpose of this study was to evaluate both clinical outcomes and satisfaction in patients who have undergone prophylactic mastectomy and breast reconstruction. Methods: A 5-year retrospective analysis of the senior author’s (S.L.S.) experience with breast reconstruction following prophylactic mastectomy was performed. Timing, type of mastectomy and reconstruction, complications, and cancer occurrence/recurrence were examined. Patients reported their level of satisfaction and willingness to undergo the procedure again. Aesthetic outcomes were graded by an independent and blinded group of surgeons. Results: There were 101 breast reconstructions performed in 74 patients following prophylactic mastectomy. With a mean follow-up of 31 months, there were three breast-site complications in this group (3 percent). Forty-seven patients in the study had a unilateral prophylactic mastectomy; on the contralateral side with cancer, there were five breast-site complications in reconstructions following therapeutic mastectomy (10 percent). Aesthetic outcome ratings by surgeons were higher in the bilateral prophylactic mastectomy and reconstruction patients compared with the cancer patients who had undergone a therapeutic mastectomy and reconstruction along with a contralateral prophylactic mastectomy; however, this difference did not reach statistical significance. Patient satisfaction was higher in the bilateral prophylactic group, with all of the patients completing the survey stating they would undergo the procedure again. Conclusions: Breast reconstruction following prophylactic mastectomy was as safe as or more safe than that following therapeutic mastectomy, which has been shown in other studies to result in a high percentage of patient satisfaction. Although not statistically significant, the results from reconstruction after prophylactic mastectomy trended toward improved aesthetic outcome with a lower complication rate compared with reconstruction after therapeutic mastectomy.
Tidal-Force-Influenced Pressure Transients for Estimating Compressibilityin a Fractured Reservoir (1999)

Tidal-Force-Influenced Pressure Transients for Estimating Compressibility in a Fractured Reservoir Eric Chang; Eric Chang Reservoir Engineering Research Institute Search for other works by this author on: This Site Google Scholar Abbas Firoozabadi Abbas Firoozabadi Reservoir Engineering Research Institute Search for other works by this author on: This Site Google Scholar Paper presented at the SPE Annual Technical Conference and Exhibition, Houston, Texas, October 1999. Paper Number: SPE-56437-MS https://doi.org/10.2118/56437-MS Published: October 03 1999 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Get Permissions Search Site Citation Chang, Eric, and Abbas Firoozabadi. "Tidal-Force-Influenced Pressure Transients for Estimating Compressibility in a Fractured Reservoir." Paper presented at the SPE Annual Technical Conference and Exhibition, Houston, Texas, October 1999. doi: https://doi.org/10.2118/56437-MS Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll ProceedingsSociety of Petroleum Engineers (SPE)SPE Annual Technical Conference and Exhibition Search Advanced Search This paper was prepared for presentation at the 1999 SPE Annual Technical Conference and Exhibition held in Houston, Texas, 3–6 October 1999. Keywords: declination, pressure transient, gravitational potential, drillstem/well testing, orbit, pressure data, disturbing body, variation, compressibility, dilatation Subjects: Reservoir Characterization, Formation Evaluation & Management, Drillstem/well testing This content is only available via PDF. 1999. Society of Petroleum Engineers You can access this article if you purchase or spend a download.
The Formation and Dissolution of Metal Sulfides<sup>1</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Formation and Dissolution of Metal Sulfides1Herbert A. PohlCite this: J. Am. Chem. Soc. 1954, 76, 8, 2182–2184Publication Date (Print):April 1, 1954Publication History Published online1 May 2002Published inissue 1 April 1954https://pubs.acs.org/doi/10.1021/ja01637a043https://doi.org/10.1021/ja01637a043research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes <i>in vivo</i> (2008)

Human species C adenovirus serotype 5 (Ad5) is the most common viral vector used in clinical studies worldwide. Ad5 vectors infect liver cells in vivo with high efficiency via a poorly defined mechanism, which involves virus binding to vitamin K-dependent blood coagulation factors. Here, we report that the major Ad5 capsid protein, hexon, binds human coagulation factor X (FX) with an affinity of 229 pM. This affinity is 40-fold stronger than the reported affinity of Ad5 fiber for the cellular receptor coxsackievirus and adenovirus receptor, CAR. Cryoelectron microscopy and single-particle image reconstruction revealed that the FX attachment site is localized to the central depression at the top of the hexon trimer. Hexon-mutated virus bearing a large insertion in hexon showed markedly reduced FX binding in vitro and failed to deliver a transgene to hepatocytes in vivo. This study describes the mechanism of FX binding to Ad5 and demonstrates the critical role of hexon for virus infection of hepatocytes in vivo.
Microglia and neuropathic pain (2009)

In contrast to physiological pain, pathological pain is not dependent on the presence of tissue-damaging stimuli. One type of pathological pain--neuropathic pain--is often a consequence of nerve injury or of diseases such as diabetes, AIDS, or cancer. Neuropathic pain can be agonizing, can persist over long periods, and, unfortunately, is often resistant to known painkillers. There is a rapidly growing body of evidence indicating that microglia, the CNS immune cells, have causal roles in the pathogenesis of pain hypersensitivity following nerve injury. We will review recent advances in our understanding of the mechanisms producing neuropathic pain, focusing on the roles of microglia-expressed molecules, including cell surface receptors, intracellular signaling molecules, and diffusible factors involved in nerve injury-induced pain behaviors and hyperexcitability of dorsal horn neurons. Elucidating how spinal microglia cause neuropathic pain may provide us with exciting insights into pain mechanisms and clues for developing new drugs for the treatment of neuropathic pain.
Integrated multi-frequency lidar / radar system for precise and robust Doppler measurements (2015)

A novel architecture of an integrated photonic assisted radar-lidar system based on a single mode-locked laser is proposed and demonstrated. The lidar exploits a multi-frequency optical signal with tunable tones separation allowing a dynamic tradeoff among robustness and sensitivity of measurements. The radar, which employs the mode-locked laser for generating and receiving the radio-frequency signal operates in the X-band and simultaneously with the lidar. Velocity measurements for different tones separation are successfully demonstrated with good agreement between lidar and radar.
Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience (2016)

Photoacoustic imaging has evolved into a clinically translatable platform with the potential to complement existing imaging techniques for the management of cancer, including detection, characterization, prognosis, and treatment monitoring. In photoacoustic imaging, tissue is optically excited to produce ultrasonographic images that represent a spatial map of optical absorption of endogenous constituents such as hemoglobin, fat, melanin, and water or exogenous contrast agents such as dyes and nanoparticles. It can therefore provide functional and molecular information that allows noninvasive soft-tissue characterization. Photoacoustic imaging has matured over the years and is currently being translated into the clinic with various clinical studies underway. In this review, the current state of photoacoustic imaging is presented, including techniques and instrumentation, followed by a discussion of potential clinical applications of this technique for the detection and management of cancer. (©) RSNA, 2016.
Offspring from intracytoplasmic sperm injection of aged mouse oocytes treated with caffeine or MG132 (2011)

Postovulatory mammalian oocytes age significantly in culture. B6D2F1 or ICR strain mouse oocytes were collected 16 h after hCG injection and then cultured for up to 40 h post hCG at 37 °C under 5% CO(2) in air. After intracytoplasmic sperm injection (ICSI), B6D2F1 and ICR oocytes lost full-term developmental potential by 30 h and 26 h after hCG administration, respectively. However, using supplementation with 10 mM caffeine or 1-5 μM of MG132, we could obtain live offspring from oocytes at 34 h (BDF1, 5%-21%) or 28 h (ICR, 5%-18%), whereas none were obtained from untreated aged oocytes. Caffeine maintained normal meiotic spindle morphology, whereas MG132 maintained maturation-promoting factor activity. These treatments did not affect the potential of fresh oocytes for fertilization and subsequent development. Thus, it should be safe to use these chemicals in routine in vitro fertilization and offspring could be generated by ICSI of aged fertilization failed oocytes.
Raman spectroscopic study on the structural changes of polyaniline during heating and cooling processes (2005)

Abstract Polyaniline (PANI) in three ground states—emeraldine base (EB), leucoemeraldine base (LEB), and pernigraniline base (PNB)—were studied by Raman spectroscopy in the temperature scale of −195 to about 375°C. The Raman spectral results demonstrated that a crosslinking reaction occurred on EB chains at high temperatures, whereas the phenyl torsion angles of EB chains decreased during the cooling process. LEB was unstable and was gradually converted to EB during the heating process, although its chain conformation remained stable by cooling. The spectral change tendency of PNB was similar to that of EB during the heating process. Although the torsion angle of PNB also decreased with decreasing temperature, like that of EB, this behavior was hard to observe experimentally because of the relatively “free ” rotation of its phenyl rings. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96:732–739, 2005
Photoacoustic correlation signal-to-noise ratio enhancement by coherent averaging and optical waveform optimization (2013)

Photoacoustic (PA) imaging of biological tissues using laser diodes instead of conventional Q-switched pulsed systems provides an attractive alternative for biomedical applications. However, the relatively low energy of laser diodes operating in the pulsed regime, results in generation of very weak acoustic waves, and low signal-to-noise ratio (SNR) of the detected signals. This problem can be addressed if optical excitation is modulated using custom waveforms and correlation processing is employed to increase SNR through signal compression. This work investigates the effect of the parameters of the modulation waveform on the resulting correlation signal and offers a practical means for optimizing PA signal detection. The advantage of coherent signal averaging is demonstrated using theoretical analysis and a numerical model of PA generation. It was shown that an additional 5-10 dB of SNR can be gained through waveform engineering by adjusting the parameters and profile of optical modulation waveforms.
Phase III Trial of Interferon Alfa-2a With or Without 13-cis-Retinoic Acid for Patients With Advanced Renal Cell Carcinoma (2000)

Response proportion and survival did not improve significantly with the addition of 13-CRA to IFNalpha2a therapy in patients with advanced RCC. 13-CRA may lengthen response to IFNalpha2a therapy in patients with IFNalpha2a-sensitive tumors. Treatment, particularly the combination therapy, was associated with a decrease in QOL.
Effects of benoxaprofen on human neutrophil function. (1984)

In vitro assays of human neutrophil phagocytosis, adherence, enzyme release, and response to chemotactic factors were utilized to determine the effects of benoxaprofen on these cells. At concentrations of 30 and 300 micrograms/ml benoxaprofen partially inhibited phagocytosis without affecting adherence. High concentrations (300 micrograms/ml) of benoxaprofen, but not aspirin or gold, enhanced the release of the granular enzymes beta-glucuronidase and lysozyme, but not the release of the cytoplasmic enzyme lactic dehydrogenase from both resting and phagocytosing neutrophils. High concentrations (300 micrograms/ml) of benoxaprofen also inhibited the response of neutrophils to chemotactic factors as determined by both the leading front and leukotactic index methods. These unique in vitro effects of this antiinflammatory agent are compatible with recent clinical reports concerning its efficacy and toxicity.
An experimental comparison study on indoor localization: RF fingerprinting and Multilateration methods (2013)

Due to an increasing number of public and private access points in indoor and urban environments, Wi-Fi positioning becomes more and more attractive. In last ten years different approaches and solutions have been developed and applied. The accuracy of these systems depends on the suitability of the propagation models used for the actual propagation conditions. In this paper, characteristic and analysis of two popular methods for indoor localization named as K-Nearest Neighbour (K-NN) algorithm based RF Fingerprinting and RF Multilateration methods are experimentally evaluated and compared according to received signal strength (RSS) of a mobile Wi-Fi user for getting a better and improved result. Transmitted signal strengths of four fixed Wi-Fi modems are measured by using a mobile Mac Computer with Wi-Fi receiver in the School of Electrical and Electronics Engineering hallways at Yildiz Technical University, Istanbul. Later, accuracy plots and modelling for better solution in small areas and LoS locations has been demonstrated for both methods. An experimental comparison results has been presented to evaluate the performance in localizing accuracy where RF Fingerprinting method shows better results than RF multilateration method while RF multilateration method offers less error rate and better solution for small areas.
Recurrent Urinary Tract Infections in Women: Prevention by Topical Application of Antimicrobial Ointment to Urethral Meatus (1970)

No AccessJournal of Urology1 Nov 1970Recurrent Urinary Tract Infections in Women: Prevention by Topical Application of Antimicrobial Ointment to Urethral Meatus Ralph R. Landes, Irving Melnick, and Allan A. Hoffman Ralph R. LandesRalph R. Landes More articles by this author , Irving MelnickIrving Melnick More articles by this author , and Allan A. HoffmanAllan A. Hoffman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)61827-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Recurrent Urinary Tract Infections in Women: Prevention by Topical Application of Antimicrobial Ointment to Urethral Meatus." The Journal of Urology, 104(5), pp. 749–750 © 1970 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByBrumfitt W, Hamilton-Miller J, Gargan R, Cooper J and Smith G (2018) Long-Term Prophylaxis of Urinary Infections in Women: Comparative Trial of Trimethoprim, Methenamine Hippurate and Topical Povidone-IodineJournal of Urology, VOL. 130, NO. 6, (1110-1114), Online publication date: 1-Dec-1983.Bruce A, Chadwick P, Seddon J and Vancott G (2018) The Significance of Perineal Pathogens in WomenJournal of Urology, VOL. 112, NO. 6, (808-810), Online publication date: 1-Dec-1974. Volume 104Issue 5November 1970Page: 749-750 Advertisement Copyright & Permissions© 1970 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Ralph R. Landes More articles by this author Irving Melnick More articles by this author Allan A. Hoffman More articles by this author Expand All Advertisement PDF DownloadLoading ...
Cooling Method Influences the Postharvest Quality of Broccoli (1995)

The effects of cooling method and packaging with perforated film on broccoli ( Brassica oleracea L. Italica group) quality during 2C storage were studied. Broccoli was either room-cooled, top-iced, or hydrocooled before being placing into storage for 14 days. Hydrocooling was the most rapid cooling method and resulted in the lowest vapor pressure deficits between the broccoli and the surrounding air. Hydrocooling and top-icing resulted in similar firmness and color retention. Broccoli that was hydrocooled and then overwrapped with perforated film lost less weight, was firmest, and retained color better than either top-iced or room-cooled broccoli.