gebhart/patrepeval huggingface dataset:
Standard/Handbook for Multipactor Breakdown Prevention in Spacecraft Components (2014)

Abstract : This document is intended to serve as a standard and handbook for the prevention of multipactor and ionization breakdown in spacecraft components and systems. The document provides minimum requirements for risk definition, system analysis, and component analysis and test. Supporting documentation describes proper design, analysis, and test guidelines while also providing the requirements for defining the proper system engineering to identify RF breakdown risks within susceptible components. The document framework is based on defining worst-case parameters as general inputs to analysis or test criteria for all components within the RF system. Using hardware-specific values, these worst-case parameters are defined separately from margin requirements. With properly defined worst-case conditions, the document addresses required margins for analysis and test for multiple devices categories. Subsequent sections provide minimum verification requirements to demonstrate the margin recommendations for both analysis and test. Applicability of different analysis and test methods to the device class categories is provided, with special cases and considerations. Multiple appendices based on state-of-the-art industry best practices are also provided as guidelines to aid manufacturers and contractors. Typical approaches including examples for both design and test are provided. A reference geometry is described along with corresponding analysis and test data. This information can be used as a benchmark standard, such that component vendors and manufacturers can have a standard example for RF breakdown.
Persister Cells Resuscitate Using Membrane Sensors that Activate Chemotaxis, Lower cAMP Levels, and Revive Ribosomes (2019)

Persistence, the stress-tolerant state, is arguably the most vital phenotype since nearly all cells experience nutrient stress, which causes a sub-population to become dormant. However, how persister cells wake to reconstitute infections is not understood well. Here, using single-cell observations, we determined that Escherichia coli persister cells resuscitate primarily when presented with specific carbon sources, rather than spontaneously. In addition, we found that the mechanism of persister cell waking is through sensing nutrients by chemotaxis and phosphotransferase membrane proteins. Furthermore, nutrient transport reduces the level of secondary messenger cAMP through enzyme IIA; this reduction in cAMP levels leads to ribosome resuscitation and rescue. Resuscitating cells also immediately commence chemotaxis toward nutrients, although flagellar motion is not required for waking. Hence, persister cells wake by perceiving nutrients via membrane receptors that relay the signal to ribosomes via the secondary messenger cAMP, and persisters wake and utilize chemotaxis to acquire nutrients.
The interface of epitaxial SrTiO3 on silicon: <i>in situ</i> and <i>ex situ</i> studies (2003)

The formation of interfacial layers between silicon and the overgrown epitaxial SrTiO3 as a function of the growth temperature has been studied in detail using x-ray photoelectron spectroscopy and high-resolution transmission electron microscopy. Models for the chemical compositions and atomic bonding states have been established. With a good understanding of the mechanisms of the interfacial layer formations, the molecular-beam epitaxy growth process can be well controlled to form high-quality, single-crystalline oxide films, as well as a desired interface between the grown oxide and silicon substrate. The epitaxial relationship has been found to be SrTiO3 (001)∥Si(001), and SrTiO3 〈100〉∥Si〈110〉.
Polarimetric optical imaging of scattering surfaces (1996)

A polarimetric optical specular event detector (OSED) has been developed to provide spatially and temporally resolved polarimetric data of backscattering in the visible from water wave surfaces. The OSED acquires simultaneous, two-dimensionally resolved images of the remote target in two orthogonal planes of polarization. With the use of plane-polarized illumination the OSED presently can measure, in an ensemble of breaking waves, the equivalent four-element polarization matrix common to polarimetric radars. Upgrade to full Stokes parameter state of polarization measurements is straightforward with the use of present single-aperture, multi-imager CCD camera technology. The OSED is used in conjunction with a coherent pulse-chirped radar (PCR), which also measures the four-element polarization matrix, to provide direct time-correlated identification of backscattering mechanisms operative during wave-breaking events which heretofore have not been described theoretically. We describe the instrument and its implementation, and examples of spatially resolved polarimetric data are displayed as correlated with the PCR backscatter cross section and polarization ratio records.
Epidermal growth factor receptor relocalization and kinase activity are necessary for directional migration of keratinocytes in DC electric fields (1999)

Human keratinocytes migrate towards the negative pole in DC electric fields of physiological strength. This directional migration is promoted by epidermal growth factor (EGF). To investigate how EGF and its receptor (EGFR) regulate this directionality, we first examined the effect of protein tyrosine kinase inhibitors, including PD158780, a specific inhibitor for EGFR, on this response. At low concentrations, PD158780 inhibited keratinocyte migration directionality, but not the rate of migration; at higher concentrations, it reduced the migration rate as well. The less specific inhibitors, genistein, lavendustin A and tyrphostin B46, reduced the migration rate, but did not affect migration directionality. These data suggest that inhibition of EGFR kinase activity alone reduces directed motility, and inhibition of multiple tyrosine kinases, including EGFR, reduces the cell migration rate. EGFR redistribution also correlates with directional migration. EGFR concentrated on the cathodal face of the cell as early as 5 minutes after exposure to electric fields. PD158780 abolished EGFR localization to the cathodal face. These data suggest that EGFR kinase activity and redistribution in the plasma membrane are required for the directional migration of keratinocytes in DC electric fields. This study provides the first insights into the mechanisms of directed cell migration in electric fields.
An 8 kbps TC-MQ (time domain compression ADPCM-MQ) speech codec (2003)

A new 8 kbps speech coding algorithm called TC-MQ (time domain compression ADPCM-MQ) is proposed. It is based on time scale modification and sub-band coding with the aid of ADPCM with a multiquantizer. For time scale modification, the decimation/interpolation technique is introduced for the unvoiced period. Furthermore, in order to get computational accuracy of the pitch extraction for the voiced period, a method using the normalized autocovariance function is proposed. The algorithm was confirmed by computer simulations. The segmental SNR was about 13-16 dB for Japanese short sentences. A good mean opinion score value was also obtained by means of a subjective evaluation test.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
PCR Technology (2013)

PCR's simplicity as a molecular technique is, in some ways, responsible for the huge amount of innovation that surrounds it, as researchers continually think of new ways to tweak, adapt, and re-formulate concepts and applications. PCR Technology: Current Innovations, Third Edition is a collection of novel methods, insights, and points of view that
Dry eye associated with laser in situ keratomileusis: Mechanical microkeratome versus femtosecond laser (2009)

Eyes with femtosecond flaps had a lower incidence of LASIK-associated dry eye and required less treatment for the disorder. In addition to neurotrophic effects from corneal nerve cutting, other factors may be important because no correlation was found between flap thickness (or ablation depth) and the incidence of LASIK-induced dry eye.
Magnetic force microscopy (MFM) studies of micromagnetic structures of high coercivity CoCrPt/Cr and CoCrPtB/Cr thin films (1995)

The magnetic microstructures of high coercivity CoCrPt/Cr and CoCrPtB/Cr films were investigated using magnetic force microscopy (MFM). Experiments show that the MFM technique can be used for both qualitative and quantitative description of the magnetic microstructure of high coercivity films for magnetic recording media. It was found that the magnetic microstructure was more refined for films with higher coercivity. The roughness of the magnetic images tend to decrease with increasing coercivity and decreasing media noise. Magnetic images obtained for films with ac-erased state consisted of rounded, symmetric features indicating presence of magnetic vortices. Images from samples in remanent coercivity state showed elongated transitions between regions with different magnetization direction.
Black pearls in the English crown (1882)

Black pearls in the English crown Get access Frederick E. Sawyer Frederick E. Sawyer 1Brighton Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s6-V, Issue 115, 11 March 1882, Pages 188–189, https://doi.org/10.1093/nq/s6-V.115.188k Published: 11 March 1882
“Durable Solutions,” Transnationalism, and Homemaking among Croatian and Bosnian Former Refugees (2015)

This article proposes that the UNHCR-supported “durable solution” programs for former refugees from Bosnia and Herzegovina and from Croatia were at odds with the actual exilic experiences of former refugees. It introduce homemaking as an essential aspect of a successful durable solution and proposes supplementing the usual ethno-politicized understandings of home in the specific context with analyses of the process of homemaking at different scales—house (dwelling), community (the wider space of settlement containing natural, cultural, social, and economic aspects) and nation. The article also argues that repatriation and local integration in the country of first asylum—two allegedly distinct and opposite solutions to refugee crises—should be viewed as intertwined processes within a broader transnational context. It is concluded that their combination brought a durable solution to refugee predicaments in the specific case.
Regulation of polyamine biosynthesis in Saccharomyces cerevisiae (2005)

Polyamines are essential organic cations with multiple cellular functions. Their synthesis is controlled by a feedback regulation whose main target is ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. In mammals, ODC has been shown to be inhibited and targeted for ubiquitin-independent degradation by ODC antizyme. The synthesis of mammalian antizyme was reported to involve a polyamine-induced ribosomal frameshifting mechanism. High levels of polyamine therefore inhibit new synthesis of polyamines by inducing ODC degradation. In this work, a previously unrecognized sequence in the genome of Saccharomyces cerevisiae encoding an orthologue of mammalian antizyme was identified. Synthesis of yeast antizyme (Oaz1) involves polyamine-regulated frameshifting. New elements, termed OFRE (OAZ1 frameshifting repressor element) and OPRE (OAZ1 polyamine responsive element) that are necessary for the polyamines to regulate frameshifting were mapped in the OAZ1 mRNA. Degradation of yeast ODC by the proteasome depends on Oaz1. Oaz1 mediates the degradation by binding to ODC thereby exposing a degradation signal at the N-terminus of ODC. Using the novel transplantable yeast ODC degradation signal (ODS) identified in this work a new possible role of the shuttle factor Rad23 in ODC degradation was identified. In addition, ODS is shown to interact with multiple 19S lid subunits in the proteasome. Using this novel model system for polyamine regulation another level of its control was discovered. Oaz1 itself is subject to ubiquitin-mediated proteolysis by the proteasome. Degradation of Oaz1, however, is efficiently inhibited by polyamines. I propose a model, in which polyamines inhibit their ODC-mediated biosynthesis by two mechanisms, the control of Oaz1 synthesis and inhibition of its degradation. In a second part of the work, peptide aptamers were isolated that inhibit the ubiquitin-dependent turnover of test substrates of the proteasome. These aptamers appear to either inhibit ubiquitylation or the proteasome and thereby lead to a stabilization of test substrates. I Propose that ODS due to its ubiquitin-independent mode of degradation can be used as a tool in aptamer screens that are aimed at identifying additional peptide inhibitors of the proteasome with potential clinical relevance.
PERSISTENCE OF bcr-abl GENE EXPRESSION FOLLOWING BONE MARROW TRANSPLANTATION FOR CHRONIC MYELOGENOUS LEUKEMIA IN CHRONIC PHASE (1991)

The bcr-abl RNA transcript is the molecular counterpart of the Philadelphia chromosome and is detectable by an extremely sensitive polymerase chain reaction assay in most patients with chronic myelogenous leukemia. To determine the effectiveness of ablative radiochemotherapy and bone marrow transplantation in eradicating molecular evidence of the malignant clone, we assayed for bcr-abl RNA expression in specimens from 19 patients with CML in chronic phase (CP) who have survived for at least one year post-BMT. We correlated these results with the patients' remission status based on cytogenetic analysis and BM morphology, and with evidence of mixed hematopoietic chimerism by analysis of RBC antigen and DNA restriction fragment length polymorphism patterns. Thirteen of the 19 patients had detectable bcr-abl RNA at some time following BMT. Twelve of these patients have remained in remission by morphologic and karyotypic criteria from 16.6 to 63.7 months following BMT. One of these 13 patients relapsed both by cytogenetic and clinical criteria at 28.1 months after BMT. Six of these 13 patients are still positive at the time of their most recent analysis. Only two patients have evidence for mixed chimerism of normal hematopoietic elements by either RBC antigen or DNA RFLP patterns. These results suggest that, in some patients transplanted for CML in CP, small numbers of residual leukemic cells may persist or reappear transiently without leading to clinical relapse. The definition of complete remission in CML may need to be revised in light of the enhanced ability to detect minimal residual disease by PCR technology.
Quasiparticle Relaxation in Optically Excited High-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>Q</mml:mi></mml:math>Superconducting Resonators (2008)

The quasiparticle relaxation time in superconducting films has been measured as a function of temperature using the response of the complex conductivity to photon flux. For tantalum and aluminum, chosen for their difference in electron-phonon coupling strength, we find that at high temperatures the relaxation time increases with decreasing temperature, as expected for electron-phonon interaction. At low temperatures we find in both superconducting materials a saturation of the relaxation time, suggesting the presence of a second relaxation channel not due to electron-phonon interaction.
A Review on Finite Element Analysis Approaches in Durability Assessment of Automotive Components (2008)

This research describes the majority of interesting findings in the use of the Finite Element Analysis (FEA) based fatigue for automotive components in a form of review write-up. Thus, the theoretical background related to the fatigue life prediction using FEA is presented which is the main subject of this research. The challenge for FEA-based software developers is to deliver reliable fatigue-analysis tools because over designing components is no longer a viable option. Combination between a fatigue model based on the crack initiation, the crack growth and the crack closures are performed with consideration of cycle sequence effect together with finite element results, which lead to the prediction of fatigue life under spectrum or service loadings.
Recruitment of Transplanted Dermal Multipotent Stem Cells to Sites of Injury in Rats with Combined Radiation and Wound Injury by Interaction of SDF-1 and CXCR4 (2008)

Systemic transplantation of dermal multipotent stem cells has been shown to accelerate both hematopoietic recovery and wound healing in rats with combined radiation and wound injury. In the present study, we explored the mechanisms governing the recruitment of dermal multipotent stem cells to the sites of injury in rats with combined injury. Male dermal multipotent stem cells were transplanted into female rats, and using quantitative real-time PCR for the sex-determining region of Y chromosome, it was found that the amounts of dermal multipotent stem cells in irradiated bone marrow and wounded skin were far greater than those in normal bone marrow and skin (P < 0.01). However, incubation of dermal multipotent stem cells with AMD3100 before transplantation, which specifically blocks binding of stromal cell-derived factor 1 (SDF-1) to its receptor CXCR4, diminished the recruitment of dermal multipotent stem cells to the irradiated bone marrow and wounded skin by 58 +/- 4% and 60 +/- 4%, respectively (P < 0.05). In addition, it was confirmed that the expression of SDF-1 in irradiated bone marrow and wounded skin was up-regulated compared to that in their normal counterparts, and in vitro analysis revealed that irradiated bone marrow and wounded skin extracts had a strong chemotactic effect on dermal multipotent stem cells but that the effect decreased significantly when dermal multipotent stem cells were preincubated with AMD3100 (P < 0.05). These data suggest that transplanted dermal multipotent stem cells were recruited more frequently to the irradiated bone marrow and wounded skin than normal bone marrow and skin and that the interactions of SDF-1 and CXCR4 played a crucial role in this process.
A 6-Aminoquinolone Compound, WC5, with Potent and Selective Anti-Human Cytomegalovirus Activity (2008)

We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of approximately 500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was approximately 10-fold less active against murine cytomegalovirus. Thus, WC5 may represent a lead for the development of new, potent, and selective anti-HCMV compounds.
The Synthesis of Oxazolines Using the Vilsmeier Reagent (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTThe Synthesis of Oxazolines Using the Vilsmeier ReagentPeter G. M. Wuts, Jill M. Northuis, and Tricia A. KwanView Author Information Chemical Process Research and Development, 1500-91-201, Pharmacia and Upjohn, Kalamazoo, Michigan 49001 [email protected]Cite this: J. Org. Chem. 2000, 65, 26, 9223–9225Publication Date (Web):November 28, 2000Publication History Received3 July 2000Published online28 November 2000Published inissue 1 December 2000https://pubs.acs.org/doi/10.1021/jo000664rhttps://doi.org/10.1021/jo000664rbrief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1977Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Anions,Chemical reactions,Pyridines,Reagents Get e-Alerts
Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration (1994)

<h3>Objective.</h3> —To evaluate the relationships between dietary intake of carotenoids and vitamins A, C, and E and the risk of neovascular age-related macular degeneration (AMD), the leading cause of irreversible blindness among adults. <h3>Design.</h3> —The multicenter Eye Disease Case-Control Study. <h3>Setting.</h3> —Five ophthalmology centers in the United States. <h3>Patients.</h3> —A total of 356 case subjects who were diagnosed with the advanced stage of AMD within 1 year prior to their enrollment, aged 55 to 80 years, and residing near a participating clinical center. The 520 control subjects were from the same geographic areas as case subjects, had other ocular diseases, and were frequency-matched to cases according to age and sex. <h3>Main Outcome Measures.</h3> —The relative risk for AMD was estimated according to dietary indicators of antioxidant status, controlling for smoking and other risk factors, by using multiple logistic-regression analyses. <h3>Results.</h3> —A higher dietary intake of carotenoids was associated with a lower risk for AMD. Adjusting for other risk factors for AMD, we found that those in the highest quintile of carotenoid intake had a 43% lower risk for AMD compared with those in the lowest quintile (odds ratio, 0.57; 95% confidence interval, 0.35 to 0.92;<i>P</i>for trend=.02). Among the specific carotenoids, lutein and zeaxanthin, which are primarily obtained from dark green, leafy vegetables, were most strongly associated with a reduced risk for AMD (<i>P</i>for trend=.001). Several food items rich in carotenoids were inversely associated with AMD. In particular, a higher frequency of intake of spinach or collard greens was associated with a substantially lower risk for AMD (<i>P</i>for trend<.001). The intake of preformed vitamin A (retinol) was not appreciably related to AMD. Neither vitamin E nor total vitamin C consumption was associated with a statistically significant reduced risk for AMD, although a possibly lower risk for AMD was suggested among those with higher intake of vitamin C, particularly from foods. <h3>Conclusion.</h3> —Increasing the consumption of foods rich in certain carotenoids, in particular dark green, leafy vegetables, may decrease the risk of developing advanced or exudative AMD, the most visually disabling form of macular degeneration among older people. These findings support the need for further studies of this relationship. (<i>JAMA</i>. 1994;272:1413-1420)
Effects of Ca <sup>++</sup> , Mg <sup>++</sup> and Na <sup>+</sup> on Heat Aggregation of Whey Protein Concentrates (1983)

ABSTRACT Effect of Ca ++ on the heat aggregation of whey protein concentrates (WPC) was compared with that of Na + and Mg ++ . On the alkaline side of the isoelectric zone, aggregation of WPC was increased by the addition of CaCl 2 , MgCl 2 or NaCl, among which CaCl 2 showed the greatest effect. The denaturation temperature of WPC determined by differential scanning calorimetry significantly decreased in the presence of CaCl 2 or MgCl 2 , but increased slightly in the presence of NaCl. In the electrophoretic patterns of heated WPC, the most sensitive protein to Ca ++ was β‐lactoglobulin.