gebhart/patrepeval huggingface dataset:
Screening and Selection of New Antagonists of the RING-Mediated Hdm2/Hdmx Interaction (2011)

Abstract : Prostate cancer poses a major public health problem in the United States and worldwide. It has the highest incidence and is the second most common cause of cancer deaths in North American men resulting in over 30,000 deaths per annum. Consequently, there is an urgent need to develop novel therapeutic approaches. We propose to use a novel cyclotide-based molecular scaffold for generating molecular libraries that will be screened and selected in vivo to identify antagonists of the RING-mediated Hdm2/Hdmx interaction. Our innovative approach will use cell-based E. coli libraries in which individual bacteria express a different cyclotide. This comprises a new single cell-single compound approach to identify protein-protein binding antagonists. These compounds will be subjected to a two-step screen, the first involving a high throughput FRET-based FACS screen in bacteria, and the second a bioluminescence complementation assay in cancer cells. Together, these assays will identify cyclotides that disrupt Hdm2-Hdmx interactions, activate p53, and elicit p53-dependent cytotoxicity in prostate cancer cells. During the second year of this project we have accomplished the following: 1) Developed a more efficient method for the biosynthesis of cyclotides in E. coli cells; 2) We have validated our FRET-based reporter to sort cell populations; 3) Developed and characterized a novel cyclotide with p53 activating properties.
Chromosomal aberrations associated with invasion in papillary superficial bladder cancer (1998)

Non-invasive and invasive papillary transitional cell carcinomas of stages pTa and pT1 represent the first steps of tumour progression in bladder cancer. In order to analyse different chromosomal alterations of pTa and pT1 superficial bladder cancer, 46 tumour specimens were examined by comparative genomic hybridization (CGH). Losses of chromosome 9 material (11/20) and gains of chromosome 17 material (6/20) were frequently found in pTa tumours. Stage pT1 tumours were characterized by gains of chromosome 1q (14/26; including amplification at 1q21-q24 in three cases) and chromosome 17 material (15/26), as well as by losses of 11p (15/26) and 11q (13/26). Other loci frequently showing losses in pT1 tumours were 2q (9/26), 4q (10/26), 5q (9/26), 8p (10/26), 9p (9/26), 9q (12/26), 10q (8/26), 17p (7/26), and 18q (8/26). Amplifications were detected at 8q21/22, 5q21, 7q36, 10p14, 10p12, 10q25, 12q12, and 12q14. The most striking differences between grade 2 pTa and pT1 tumours were gains of 1q (P < 0.01) and losses at 2q (P < 0.025), 10q (P < 0.05), 11p (P < 0.01), 11q (P < 0.01), and 17p (P < 0.05), as well as the total number of aberrations (pTa grade 2: 4.1; pT1 grade 2: 8.6 aberrations per tumour). These data show characteristic chromosomal aberrations associated with invasion in superficial bladder cancer.
Production and Use of Stable Isotope-Labeled Proteins for Absolute Quantitative Proteomics (2011)

In the field of analytical chemistry, stable isotope dilution assays are extensively used in combination with liquid chromatography-mass spectrometry (LC-MS) to provide confident quantification results. Over the last decade, the principle of isotope dilution has been adopted by the proteomic community in order to accurately quantify proteins in biological samples. In these experiments, a protein's concentration is deduced from the ratio between the MS signal of a tryptic peptide and that of a stable isotope-labeled analog, which serves as an internal standard. The first isotope dilution standards introduced in proteomics were chemically synthesized peptides incorporating a stable isotope-tagged amino acid. These isotopically labeled peptide standards, which are currently widely used, are generally added to samples after protein isolation and digestion. Thus, if protein enrichment is necessary, they do not allow correction for protein losses that may occur during sample pre-fractionation, nor do they allow the tryptic digestion yield to be taken into account. To reduce these limitations we have developed the PSAQ (Protein Standard Absolute Quantification) strategy using full-length stable isotope-labeled proteins as quantification standards. These standards and the target proteins share identical biochemical properties. This allows standards to be spiked into samples at an early stage of the analytical process. Thanks to this possibility, the PSAQ method provides highly accurate quantification results, including for samples requiring extensive biochemical pre-fractionation. In this chapter, we describe the production of full-length stable isotope-labeled proteins (PSAQ standards) using cell-free expression devices. The purification and quality control of protein standards, crucial for good-quality and accurate measurements, are also detailed. Finally, application of the PSAQ method to a typical protein quantification assay is presented.
Nonpolar resistance switching of metal/binary-transition-metal oxides/metal sandwiches: Homogeneous/inhomogeneous transition of current distribution (2008)

Exotic features of a metal/oxide/metal sandwich, which will be the basis for a drastically innovative nonvolatile memory device, is brought to light from a physical point of view. Here the insulator is one of the ubiquitous and classic binary-transition-metal oxides (TMO), such as ${\mathrm{Fe}}_{2}{\mathrm{O}}_{3}$, $\mathrm{NiO}$, and $\mathrm{CoO}$. The sandwich exhibits a resistance that reversibly switches between two states: one is a highly resistive off state and the other is a conductive on state. Several distinct features were universally observed in these binary TMO sandwiches: namely, nonpolar switching, nonvolatile threshold switching, and current-voltage duality. From the systematic sample-size dependence of the resistance in on and off states, we conclude that the resistance switching is due to the formation of ``electric faucet'' at the interface, which shows up as a homogeneous to inhomogeneous transition of the current distribution.
Pedagogía y arquitectura (2011)

Las letras: arquitectura del placer Puedes considerar este libro de diferentes formas: como un libro clasico,hojeando sus paginas, como una escultura de papel por la que vasa pasear... Puedes observar cada letra, tocarla, leerla en voz alta... Cadauna tiene su propio sonido, su propia forma y su propio color. Notarassus diferencias cuando escuches el sonido de tu propia voz al pronunciarlas. Esta es mi ciudad de papel, ique la disfrutes!
IMMIX-intrusion detection and prevention system (2015)

Computer security has become a major problem in our society. Specifically, computer network security is concerned with preventing the intrusion of an unauthorized person into a network of computers. An intrusion detection system (IDS) is a tool to monitor the network traffic and users activity with the aim of distinguishing between hostile and non-hostile traffic. Most of current networks implement Misuse detection or Anomaly detection techniques for Intrusion detection. By deploying misuse based IDS it cannot detect unknown intrusions and anomaly based IDS have high false positive rate for detection. To overcome this, proposed system uses combination of both network based and host based IDPS as Hybrid Intrusion Detection and Prevention System which will be helpful for detecting maximum attacks on networks.
Technology and reliability constrained future copper interconnects. I. Resistance modeling (2002)

A realistic assessment of future interconnect performance is addressed, specifically, by modeling copper (Cu) wire effective resistivity in the light of technological and reliability constraints. The scaling-induced rise in resistance in the future may be significantly exacerbated due to an increase in Cu resistivity itself, through both electron surface scattering and the diffusion barrier effect. The impact of these effects on resistivity is modeled under various technological conditions and constraints. These constraints include the interconnect operation temperature, the effect of copper-diffusion barrier thickness and its deposition technology, and the quality of the interconnect/barrier interface. Reliable effective resistivity trends are established at various tiers of interconnects, namely, at the local, semiglobal, and global levels. Detailed implications of the effect of resistivity trends on performance are addressed in the second part of this work.
Effect of flow disturbance on ultrasonic backscatter from blood (1984)

Due to the better resolution and performance provided by the new generation of real-time high resolution ultrasonic scanners, blood now becomes a tissue which can also be visualized ultrasonically. There is strong experimental evidence indicating that the echogenicity of blood is increased as a result of erythrocyte aggregation. In this paper, we will show that flow disturbance may also play a significant role in influencing blood ultrasonic backscatter or echogenicity. Our results indicate that the introduction of turbulent flow can cause ultrasonic backscatter from erythrocyte suspensions to increase appreciably for hematocrits greater than 10%. We will also show that this increase may be correlated to the turbulent intensity. Moreover, the scattering peak is observed to shift to lower hematocrits when turbulence is eliminated. Experimental results obtained for uniform flow are in excellent agreement with theoretical models for small spherical scatterers which predict a scattering maximum at a hematocrit of 13%.
Evaluation of available MHD seed-regeneration processes on the basis of energy considerations (1978)

Of the several processes described in the literature that are capable of separating sulfur from alkali-metal sulfates, seven processes were selected as candidates for regenerating seed material for reuse in open-cycle MHD. After a brief assessment of each process, two were selected for a detailed analysis, namely, a process developed by the Pittsburgh Energy Research Center (PERC) and a modified version of the Tampella process. The processes were compared on the bases of energy requirements and the amount of research work needed to develop a seed-regeneration process for MHD systems. The energy requirements given should be considered as rough values, because factors such as heat losses and component efficiency were not included in the analysis. On the basis of energy consumption, the PERC process has a slight advantage over the Tampella process; on the basis of the present state of development of various components, the Tampella process has a clear advantage. Accordingly, it was recommended that developmental programs be carried out for both the PERC and Tampella processes.
Serious Complications Associated with External Intrathecal Catheters Used in Cancer Pain Patients (2009)

Serious complications are rare in both hospitalized and homebound patients with intrathecal catheters. This analysis supports the reasoning that the potential benefit of intrathecal catheters in the treatment of severe cancer pain is likely to outweigh the potential for serious complications associated with this technique. Therefore, an external intrathecal catheter can be considered an effective and low-cost solution for the control of pain in such patients.
Development and Testing of a Hybrid Boosting Pump (2011)

Abstract Subsea boosting of hydrocarbon flow, either directly from the well or from a subsea separator, will typically result in the need of handling some free gas. Pumping moderate gas volume fractions (GVF) in combination with high pressure increase, is typical for boosting flow from deep water wells and represent a challenge in pump design. Aker Solutions has developed such a pump, called a HybridBooster. This paper presents the design process of such a multistage pump from CFD-simulations to the complete full scaled testing. The hybrid pump design is flexible and suitable for a wide range of flow rates and GVF's due to the many stacking possibilities of impellers with different characteristics. This allows for making a pump with the best possible performance and efficiency. The two-phase testing was done with a mixture of water and air at Aker Solutions facility in Tranby. The pump generates a differential pressure in the range of 150 to 240 bar, depending on the rotational speed and flow rate, at 20% GVF with a suction pressure of 12 bar. The pump design is based on a combination of mixed-flow impellers and radial impellers. Test results show that the mixed-flow impeller technology have great potential for moderate GVF at all flow rates and high GVF capability at best efficiency point and above. The strength of the mixed-flow impeller is the internal remixing of gas and liquid that strongly reduces the risk of gas blocking in the flow channel. The behavior of the pump during testing was stable, granting easy pump control. Introduction The Hybrid Pump Project is a Joint Industry Project supported by Demo 2000 The Research Council of Norway and the following companies: Aker Solutions, Statoil ASA, Total E&P Norway, Nexen Exploration Norway AS, ExxonMobil Upstream Research Company USA. The large variety of oil field characteristics demands a range of tooling for a successful production. One of these tools is the subsea HybridBooster. Unlike a conventional single phase (liquid) pump the hybrid pump is able to pump a liquid/gas mixture with a high pressure increase. The HybridBooster will be a well-suited and cost and production-efficient solution in a number of applications. Typical applications are:Pumping liquid from a gas/liquid separator where a risk for gas carry-under existPumping hydrocarbons from fields producing mainly liquid, but with risk of gas break-through over time To meet the challenging requirements of handling an increased fraction of gas combined with high pressure increase a Hybrid pump development project was established. The key specifications for the subsea Hybrid Pump development are:Pressure increase - target: 200 bar, min. 100 barGas tolerance, base case - target: 20% GVFGas tolerance, advanced case - target: &gt;30% GVFInlet Pressure - &gt; 10 bar, &lt; 50 barFlow - within power limit of 2,5 MW The major design criterion was to design a gas tolerant multi-stage pump that could handle 20% GVF at suction condition, with stable operating conditions and predictable behavior.
Appliance usage prediction using a time series based classification approach (2012)

Energy management for residential homes and offices require the prediction of the usage(s) or service request(s) of different appliances present in the house. The hardware requirement is more simplified and practical if the task is only based on energy consumption data and no other sensors are used. The proposed model tries to formalize such an approach using a time-series based multi-label classifier which takes into account correlation between different appliances among other factors. In this work, prediction results are shown for 1-hour in the future but this approach can be extended to predict more hours in the future as per the requirement(with restrictions). The learned models and decision tree showing the important factors in the input information is also discussed.
Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial (2009)

clinicaltrials.gov NCT00335790.
3D multimodal cardiac data reconstruction using angiography and computerized tomographic angiography registration (2015)

The advantage of this method is to aid specialists to determine a visual relationship between the correspondent coronary arteries from two modalities and also set up a connection between stenosis points from an X-ray angiography along with their 3D positions on the coronary arteries from computerized tomographic angiography. Moreover, another benefit of this work is that the medical acquisition standards remain unchanged, which means that no calibration in the acquisition devices is required. It can be applied on most computerized tomographic angiography and angiography devices.
Reactions of organic compounds: A textbook for the advanced student (Fuson, Reynold C.) (1963)

ADVERTISEMENT RETURN TO ISSUEPREVBook and Media Revie...Book and Media ReviewNEXTReactions of organic compounds: A textbook for the advanced student (Fuson, Reynold C.)Arthur G. Anderson Jr.Cite this: J. Chem. Educ. 1963, 40, 5, 280Publication Date (Print):May 1, 1963Publication History Received3 August 2009Published online1 May 1963Published inissue 1 May 1963https://doi.org/10.1021/ed040p280.1RIGHTS & PERMISSIONSArticle Views150Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (708 KB) Get e-Alerts Get e-Alerts
Integrating sensors and actuators into RFID tags (2008)

As applications of RFID tags and systems expand, there is an increasing need to integrate sensors into RFID tags. The RFID tags being used at present in the supply chain indicate what a product is, but do not reveal any information about conditions that the product has encountered throughout its passage along the supply chain. Only a few RFID tags with sensors are commercially available and they are custom-designed tag–sensor combinations. Adding sensors that can measure environmental conditions such as temperature, vibration, chemicals, gases, and health, and the capability to interrogate the sensor outputs, can provide much needed information about the current and historical conditions of the product. The ability to incorporate sensors and possibly actuators into RFID tags would also open a whole new world of imaginable applications in homeland defense, military operations, manufacturing, animal health, medical operations, and other applications. The IEEE (Institute of Electrical and Electronics Engineers) 1451 suite of standards [1–9] was developed to provide for “smart” transducers (sensors and actuators) and flexible network interfaces that facilitate “plug-and-play” capabilities for the transducers. The objective of this chapter is to present the current situation in RFID systems and networked transducers and to describe the strategy that is being adopted and research that will be necessary in order to incorporate “smart” sensors and actuators into existing RFID tags and systems using the IEEE 1451 suite of standards approach.
Differentiation of chronic lesions after stroke in stroke‐prone spontaneously hypertensive rats using diffusion weighted MRI (1993)

Apparent diffusion coefficients (ADCs) of tissue water were determined in chronic brain lesions of a rat stroke model, stroke-prone spontaneously hypertensive rats and compared with histology. ADCs increased in the order control < edema < gliosis < cyst. The differences between individual groups were statistically significant. The increase in ADC is thought to mainly reflect a relative increase in the extracellular space in brain tissue. ADC values may be a clinically useful parameter for tissue characterization.
Medical Marijuana and Personal Autonomy, 37 J. Marshall L. Rev. 1253 (2004) (2004)

A. A Clash between Federal and State LawDiane Monson was in pain.She suffered from a "degenerative disease of the spine" that caused frequent severe back spasms and chronic back pain. 1 Her doctor had recommended that she smoke marijuana to relieve her pain, and to that end she had cultivated six small marijuana plants in the backyard of her Butte County, California home. 2 Law enforcement, however, was hot on her trail.Monson and her husband were the previous owners of another house on which Butte County sheriffs deputies had found a large amount of growing marijuana. 3 Their interest in Monson sparked, sheriffs deputies flew over Monson's house and spotted marijuana growing in her backyard, but these deputies were unable to immediately determine how much marijuana was present. 4 To further their investigation, the sheriffs deputies, along with several federal agents, raided the Monson home on August 15, 2002.'The officers found only six small marijuana plants, and the local sheriffs deputies determined that Monson's possession of the plants was legal under California statutory law. 6 California law allows individuals, on the recommendation of a doctor, to possess and consume marijuana for valid medical Judicial clerk to the Honorable Judge Charles R. Norgle,
Probabilistic Integration of Partial Lexical Information for Noise Robust Haptic Voice Recognition (2012)

This paper presents a probabilistic framework that combines multiple knowledge sources for Haptic Voice Recognition (HVR), a multimodal input method designed to provide efficient text entry on modern mobile devices. HVR extends the conventional voice input by allowing users to provide complementary partial lexical information via touch input to improve the efficiency and accuracy of voice recognition. This paper investigates the use of the initial letter of the words in the utterance as the partial lexical information. In addition to the acoustic and language models used in automatic speech recognition systems, HVR uses the haptic and partial lexical models as additional knowledge sources to reduce the recognition search space and suppress confusions. Experimental results show that both the word error rate and runtime factor can be reduced by a factor of two using HVR. 1
Fermentability of Novel Type-4 Resistant Starches in In Vitro System (2018)

Resistant starches are non-digestible starches that are fermented in the colon by microbiota. These carbohydrates are prebiotic and can be beneficial to consumer health. Many types of resistant starch exist with varying physical properties that may result in differences in fermentability. The objective of this research project was to compare potential prebiotic effects and fermentability of four novel resistant starches using an in vitro fermentation system and measuring changes in total gas production, pH, and formation of SCFAs (short chain fatty acids). Fecal donations were collected from seven healthy volunteers. Four novel resistant starches, modified potato starch (MPS), modified tapioca starch (MTS), and modified maize starches (MMS-1 and MMS-2), were analyzed and compared to polydextrose and short chain fructooligosaccharides (FOS) as controls. After twenty-four hours of fermentation, MPS and MTS responded similarly in gas production (74 mL; 70.6 mL respectively), pH (5.93; 5.93 respectively), and SCFA production (Acetate: 115; 124, Propionate: 21; 26, Butyrate: 29; 31 μmol/mL respectively). While MMS-1 had similar gas production and individual SCFA production, the pH was significantly higher (6.06). The fermentation of MMS-2 produced the least amount of gas (22 mL), with a higher pH (6.34), and lower acetate production (78.4 μmol/mL). All analyzed compounds were fermentable and promoted the formation of beneficial SCFAs.