gebhart/patrepeval huggingface dataset:
Accessibility of nano-crossbar arrays of resistive switching devices (2011)

This paper discusses the accessibility of nano-crossbar arrays of resistive switching devices, using both analytical approaches and statistical simulations. Voltage configurations of the wordlines and bitlines in crossbar arrays play a critical role on sensing margin, disturbance, and power efficiency. Access resistance to the array affects the actual line voltage and degrades the sensing margin. Nonlinearity in switching device characteristics may improve accessibility of crossbar arrays.
Restriction endonuclease digest patterns of chromosomal DNA from group B  -haemolytic streptococci (1991)

Scanning densitometry and computer-assisted numerical analysis were used to examine restriction endonuclease digest patterns (RDPs) of chromosomal DNA from 26 infecting strains and 44 vaginal isolates of group B beta-haemolytic streptococci (GBS). At the 95% similarity level, HindIII RDPs of serotype Ia and III strains clustered into four and three RDP types, respectively. Nine of 10 strains from neonates with early-onset septicaemia belonged to two particular RDP types (Ia-3 and III-3). In contrast, serotype III GBS strains from meningitis cases were not characterised by particular RDP types. Associations between RDPs and certain phenotypic characteristics were also found.
Hepatitis C Virus NS5A Inhibits Mixed Lineage Kinase 3 to Block Apoptosis (2013)

Hepatitis C virus (HCV) infection results in the activation of numerous stress responses including oxidative stress, with the potential to induce an apoptotic state. Previously we have shown that HCV attenuates the stress-induced, p38MAPK-mediated up-regulation of the K(+) channel Kv2.1, to maintain the survival of infected cells in the face of cellular stress. We demonstrated that this effect was mediated by HCV non-structural 5A (NS5A) protein, which impaired p38MAPK activity through a polyproline motif-dependent interaction, resulting in reduction of phosphorylation activation of Kv2.1. In this study, we investigated the host cell proteins targeted by NS5A to mediate Kv2.1 inhibition. We screened a phage-display library expressing the entire complement of human SH3 domains for novel NS5A-host cell interactions. This analysis identified mixed lineage kinase 3 (MLK3) as a putative NS5A interacting partner. MLK3 is a serine/threonine protein kinase that is a member of the MAPK kinase kinase (MAP3K) family and activates p38MAPK. An NS5A-MLK3 interaction was confirmed by co-immunoprecipitation and Western blot analysis. We further demonstrate a novel role of MLK3 in the modulation of Kv2.1 activity, whereby MLK3 overexpression leads to the up-regulation of channel activity. Accordingly, coexpression of NS5A suppressed this stimulation. Additionally we demonstrate that overexpression of MLK3 induced apoptosis, which was also counteracted by NS5A. We conclude that NS5A targets MLK3 with multiple downstream consequences for both apoptosis and K(+) homeostasis.
<b>The Synthesis of <b><i>cis</i></b>- and <b><i>trans</i></b>-3-Hydroxy-L-proline, Two New Amino Acids from the Antibiotic Telomycin</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of cis- and trans-3-Hydroxy-L-proline, Two New Amino Acids from the Antibiotic TelomycinJohn C. Sheehan and Joel G. WhitneyCite this: J. Am. Chem. Soc. 1963, 85, 23, 3863–3865Publication Date (Print):December 1, 1963Publication History Published online1 May 2002Published inissue 1 December 1963https://pubs.acs.org/doi/10.1021/ja00906a027https://doi.org/10.1021/ja00906a027research-articleACS PublicationsRequest reuse permissionsArticle Views327Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PP.30.15 (2015)

Objective: The individual and combined impact of modifiable lifestyle factors on hypertension was evaluated in the Korean middle-aged population. Design and method: 2,379 men and 2,622 women aged 40 to 69, without hypertension and cardiovascular diseases at baseline, were followed during 4 years. Modifiable risk factors were consisted of five high-risk lifestyle factors (being obesity, heavy alcohol intake or alcohol abstinence, high sodium intake, lack of exercise, and ever cigarette smoking). Cox proportional hazard regression was used to estimate the hazard ratios for the individual and combined risk factors. To assess the individual and combined impact of lifestyle risk factors for hypertension incidence, population attributable risk (PAR) was calculated. Results: Individuals with lower education and monthly income level had increasing number of high-risk lifestyle factors. The PAR were 21% for being obesity, 22% for lack of exercise, 18% of abstinent or heavy drinking, 9% for ever cigarette smoking, and 8% for high sodium intake. All individual lifestyle risk factors were positively associated with the incidence of hypertension, except for ever cigarette smoking (Table). Hypertension incidence was increased by increasing number of high-risk lifestyle factors (Figure). Men and women who had 4 or 5 high-risk lifestyle factors were a 1.79-fold (95% CI, 1.15–2.79) and a 2.38-fold (95% CI, 1.70–3.34) more likely to develop hypertension during 4 years than those who have none or one risk factor, respectively. The cumulative incidence in individuals with four or five high-risk lifestyle factors was higher in women than in men (24.4% in men vs 33.7% in women).Conclusions: Four modifiable lifestyle risk factors, obesity, lack of exercise, none or heavy drinking, and high sodium intake, were significantly associated with hypertension incidence. The PAR for combination of five risk factors was about 58% for hypertension. Especially, our data showed that a regular exercise and a weight loss program will play a key role in decreasing a burden caused by hypertension and its complications.
Nkx3.1, a murine homolog of Drosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands (2000)

Nkx3.1 is a homeobox gene related to Drosophila bagpipe. Nkx3.1 is an early marker of the sclerotome and a subset of vascular smooth muscle cells, and at later stages, this gene is expressed in the prostate, palatine glands, kidney, and restricted regions of the central nervous system. In the present study, we determined the chromosomal localization of Nkx3.1 and examined the function of Nkx3. 1 in vivo by using gene targeting technique. Interestingly, Nkx3.1 mapped to the central region of the mouse chromosome 14 and was linked to Nkx2.6, a murine homolog of Drosophila tinman. Homozygous mutant mice for Nkx3.1 were viable and fertile, and the phenotype was, unexpectedly, confined to the prostate and palatine glands. The homozygous mutant mice exhibited defective branching morphogenesis of the prostate and palatine glands. Moreover, epithelial cells of the mutant prostate and palatine glands showed significant hyperplasia. No abnormalities were detected in the sclerotome, blood vessels, kidney, or brain. These results indicate that Nkx3.1 plays a critical role in epithelial branching and proliferation in the prostate and palatine glands. However, we did not observe prostate cancer in homozygous mutant mice up to 2 years of age. Therefore, involvement of NKX3.1 in carcinogenesis in men needs to be carefully determined by further investigation.
Softgreen: Towards energy management of green office buildings with soft sensors (2012)

This paper describes an approach for saving energy in commercial buildings, based on the information gathered from pre-existing opportunistic context sources. Most energy management systems rely on a heavy instrumentation strategy to infer occupancies, and unfortunately ignore already available opportunistic context sources, that can provide significant information about occupancy. We present models to conduct a Context Profiling with available context sources, to infer spatial occupancy measures. Further, we model electrical loads of several types to infer potential energy savings. Through a pilot study of a building with 5 users for 30 days, we identify intra-building areas where additional instrumentation of occupancy sensors is not necessary and demonstrate potential for significant reduction in energy consumption. We believe such Context Profiling can provide insights to significantly reduce deployment and management costs for future occupancy detection and energy management systems.
Has a consensus NL generation architecture appeared, and is it psycholinguistically plausible? (1994)

I survey some recent applications-oriented NL generation systems, and claim that despite very different theoretical backgrounds, these systems have a remarkably similar architecture in terms of the modules they divide the generation process into, the computations these modules perform, and the way the modules interact with each other. I also compare this 'consensus architecture' among applied NLG systems with psycholinguistic knowledge about how humans speak, and argue that at least some aspects of the consensus architecture seem to be in agreement with what is known about human language production, despite the fact that psycholinguistic plausibility was not in general a goal of the developers of the surveyed systems.
[Study on the expression of pig zona pellucida-3 beta excluding N-terminus signal peptide and C-terminus transmembrance-like domain in Escherichia coli]. (2001)

Pig oocytes are surrounded by an acellular translucent envelope-zona pellucida(pZP), which is comprised of three biochemically and immunologically distinct glycoproteins(pZP1, pZP3 alpha and pZP3 beta). Due to the cross-reactivity of anti-pZP3 beta antibodies with human ZP in vitro, pZP3 beta has been considered as potential one of immunogens for developing human contraceptive vaccine. In order to express pZP3 beta directly in E. coli; we amplified the core fragment of pZP3 beta cDNA by PCR that was deleted 5'- and 3'-terminal sequences of coding for signal peptide and transmembrane-like domain. The DNA sequenced EcoRI and SalI restriced core fragment was cloned in a frame downstream of PRPL promoter in the pBV221 vector. SDS-PAGE analysis showed that pZP3 beta protein was expressed especially in E. coli after thermal induction, which the expression band displayed the molecular weight of about 38 kD matching with its deduced molecular weight(36.5 kD). In addition, the specially expressed protein band on SDS-PAGE gel showed specific immunological reaction with anti-pig ZP IgGs of rabbit in Western blot.
Single Antenna Attitude Algorithm for Nonuniform Antenna Gain Patterns (2007)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Description and theory of the torsion seismometer (1925)

Authors9 Abstract In this paper the torsion seismograph is considered comprehensively. Reference is made to the research program, under which it was developed, and to several cognate undertakings. The advantages of photographic registration, and of small instrumental dimensions, are pointed out. The principle of the torsion suspension, and its properties, are discussed. The construction of the instrument and its adjustments are described. An abridged theory of the seismometer is given, especially for the case of critical damping. Its action as an accelerometer is emphasized. The terms “efficiency,” “magnification,” and “efficiency with respect to velocity of vibration,” and also “sensitiveness” are formulated and defined. Methods for determining the constants are given. Auxiliary apparatus and methods are described. Appendix : In the appendix the theory of the seismometer is treated more fully and more generally. Special cases are discussed. “Sensitiveness” is discussed in its relation to “efficiency” and “magnification,” and to damping also. The decay of proper motion is considered and the best value of damping is approximated. The case of an “impulse” is defined and considered; also the case of a number of successive “impulses,” as defined. The case of a constant angular acceleration is discussed. Finally, sample seismographic records are shown and described.
Construction Of The Cognac Platform, 1025 Feet Of Water, Gulf Of Mexico (1979)

ABSTRACT Shell Oil Company recently completed the design and installation of a three-part platform in 1025 feet of water, Gulf of Mexico. The jacket was fabricated in three separate pieces in Morgan City, Louisiana. The water depth dictated a unique design, and more particularly a unique installation concept. the lower, or base section, was installed in 1977 and connected to the seafloor with 24 pilings. The middle section was mated to the base section in July of 1978, and the top section placed on the mid section later that same month. Approximately 700 companies played a role in the construction of the Cognac platform. Most were domestic, but companies from Italy, Holland, France, Spain, Germany, Britain and Norway also contributed. INTRODUCTION The area named "Cognac" consists of four tracts located 12 miles southeast of the mouth of the Mississippi River (Figure 1). In the March 1974 lease sale Shell and co-owners acquired three of the blocks for $214MM. Amoco and co-owners leased the other block for $81MM. A field unitization agreement was reached in July of 1977. Exploratory drilling started in June 1975 and was completed in July of 1976. This nine-well program resulted in discovery of eight oil and gas bearing sands at depths between 5,000 and 11,000 feet. Water depth over the four tracts ranges from 650 feet in the northwest corner to 1,650 feet in the southeast corner. In June of 1974 Shell signed a letter of intent for platform construction and installation with J. Ray McDermott, Inc., of New Orleans. A schedule calling for installation of the platform by late 1978 was developed. PLATFORM CHARACTERISTICS Over 100 drainage points are required to develop the reserves on the four tracts. Consequently, the platform (Figure 2) has 62 well slots, including two curved conductor sleeves which are oriented towards the southeast. To develop the field in a timely manner the deck was designed to support two drilling rigs. The J-tube approach to pipeline and flowline riser installation was chosen and eleven J-tubes were built in. Of these, eight are sized to handle eight-inch or smaller flowlines, two are sized to handle 12-inch lines, and one is sized to handle a 16-inch line. This allows sufficient flexibility for future gathering lines or possible future underwater development. The platform is located close to the middle of the four-block lease, specifically 385.8 ft. south and 162.4 ft. west of the northeast corner of Mississippi Canyon Block 194. A two-level deck, approximately 180 feet by 200 feet in plan dimensions, has a total of 66,500 feet of useable work area. The top level is 1099 feet above the mud-line, and 74 feet above the Mean Gulf Level (MGL). Clear span between the lower level and MGL is 56 feet.
Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows. (1981)

Patients with familial dysbetalipoproteinemia (F. Dys.), also called familial type 3 hyperlipoproteinemia, are homozygous for a mutant allele, Ed, that specifies an abnormal form of apoprotein (apo) E, a prominent constituent of remnant lipoproteins derived from very low density lipoproteins (VLDL) and chylomicrons. Apo E is thought to mediate the removal of remnant lipoproteins from the plasma by virtue of its ability to bind to hepatic lipoprotein receptors. In F. Dys. patients, remnant-like lipoproteins accumulate, apparently because of delayed clearance by the liver. In the current studies, we show that the abnormal protein specified by the Ed allele (apo E-D) from some, but not all, patients with F. Dys. has a markedly deficient ability to bind to low density lipoprotein (LDL) receptors. Apo E was isolated from eight control subjects and nine patients with F. Dys. and incorporated into phospholipid complexes. The complexes were tested for their ability to compete with human 125I-LDL or rabbit 125I-beta-VLDL fo binding to LDL receptors in four assay systems: cultured human fibroblasts, solubilized receptors from bovine adrenal cortex, liver membranes from rats treated with 17 alpha-ethinyl estradiol, and liver membranes from normal rabbits. The apo E-D from six of the nine patients with F. Dys. showed binding affinities for LDL receptors that were reduced by greater than 98% in all receptor assays (group 1 patients). All of these group 1 patients were unequivocally of phenotype apo E-D/D by the criterion of isoelectric focussing. The apo E from the three other F. Dys. patients showed a near normal binding ability in all four of the receptor assays (group 2 patients). One of these group 2 patients appeared to have the apo E-D/D phenotype by isoelectric focussing. In the other two patients in group 2, apo E-D was the predominant protein (phenotype, apo E-D/D), but traces of protein in the region corresponding to normal apo E (apo E-N) were also present. The difference between group 1 and group 2 patients was also apparent when the apo E was iodinated and tested directly for binding to liver membranes from rats treated with 17 alpha-ethinyl estradiol. The 125I-labeled apo E from a group 2 patient, but not a group 1 patient, showed enhanced uptake when perfused through the liver of an estradiol-treated rate, indicating that the receptor binding ability of apo E correlated with uptake in the intact liver. The current studies allow the subdivision of patients with F. Dys. into two groups. In group 1, the elevated plasma level of remnants appears to be due to a diminished receptor binding activity of the abnormal protein specified by the Ed allele; in group 2 patients, the cause of the elevated plasma level of remnants remains to be explained.
Abstracting of legal cases (1997)

ing of Legal Cases: The SALOMON Experience Marie-Francine Moens, Caroline Uyttendaele, Jos Dumortier Interdisciplinary Centre for Law and IT (ICRI) K.U. Leuven Tiensestraat 41 B-3000 Leuven Belgium {marie-france.moens, caroline.uyttendaele, jos.dumortier}@law.kuleuven.ac.be
Protective Function of Transcription Factor TR3 Orphan Receptor in Atherogenesis (2002)

Our results reveal that TR3 and possibly other members of this transcription factor subfamily inhibit vascular lesion formation. These transcription factors could serve as novel targets in the treatment of vascular disease.
Epidemiology of Vasomotor Rhinitis (2009)

Vasomotor rhinitis is the most common form of nonallergic rhinitis, comprising approximately 71% of all nonallergic rhinitis conditions. Although the epidemiology of this subtype of nonallergic rhinitis has not been definitively studied, it is estimated that 14 million Americans suffer from vasomotor rhinitis, with a worldwide prevalence approaching 320 million.
Induction by bufalin of differentiation of human leukemia cells HL60, U937, and ML1 toward macrophage/monocyte-like cells and its potent synergistic effect on the differentiation of human leukemia cells in combination with other inducers. (1992)

We have recently demonstrated that bufalin is a new potent inducer of the differentiation of human myeloid leukemia cells. The present work was carried out to examine further the effect of bufalin on the growth and characteristics of human leukemia-derived cell lines U937, ML1, and HL60. At concentrations of 5-10 nM, bufalin decreased the growth of ML1 cells preferentially at the G2 phase and U937 cells at the S and G2 phases of the cell cycle. Bufalin, under these conditions, induced the differentiation of U937, ML1, and HL60 cells to monocyte/macrophage-like cells by measuring the expression of various differentiation markers, as assessed by morphology and histochemistry, and ability to phagocytose latex particles, to reduce nitroblue tetrazolium, and to develop Fc receptors. U937 and ML1 cells started to differentiate at 4 and 6 h, respectively, after treatment with 10 nM bufalin and showed maximum differentiation 72 h later. At present, a mechanism for the bufalin-mediated induction of the differentiation of these human leukemia cells remains to be determined. The combination of bufalin with all-trans retinoic acid, 1 alpha,25-dihydroxyvitamin D3, 4'-demethylepipodophyllotoxin ethylidene-beta-D-glucoside (VP16), or human gamma-interferon synergistically induced the differentiation of HL60 and U937 cells. A similar effect on ML1 cells was observed with the combination of bufalin with VP16 or human rTNF-alpha. These results suggest that bufalin in combination with VP16, all-trans retinoic acid, 1 alpha,25-dihydroxyvitamin D3, rTNF-alpha, or gamma-interferon may be very useful in the differentiation of human leukemia.
Antibiotics and enzymes produced by the biocontrol agent Streptomyces violaceusniger YCED-9 (1998)

Streptomyces violaceusniger strain YCED-9 is an antifungal biocontrol agent antagonistic to many different classes of plant pathogenic fungi. We discovered that strain YCED-9 produces three antimicrobial compounds with antifungal activity. These compounds were purified and identified, and included: AFA (Anti-Fusarium Activity), a fungicidal complex of polyene-like compounds similar to guanidylfungin A and active against most fungi except oomycetes; nigericin, a fungistatic polyether; and geldanamycin, a benzoquinoid polyketide highly inhibitory of mycelial growth of Pythium and Phytophthora spp. Antimicrobial assays were developed to estimate the production of each antibiotic independently. Medium composition had differential effects on the production of each metabolite. The hydrolytic enzymes chitinase and -1,3-glucanase are also produced under induction by colloidal chitin and laminarin, respectively. Fungal cell walls induced the production of both enzymes. A potential for biological control of diseases caused by P. infestans was also suggested by strain YCED-9's strong in vitro antagonism towards pathogenic isolates of this fungus.