gebhart/patrepeval huggingface dataset:
Synthesis and Properties of Zeolitic Membranes (2003)

Zeolite-based separations involve pressure swing or temperature swing adsorption. These are unsteady-state processes which rely on cycles of preferential adsorption (of one component over the other) and subsequent desorption. Replacement of a swing adsorption process with a steady-state process is arguably advantageous for several reasons, including lower operating costs and reduced energy consumption. Over the last decade, much attention has been focused on the development of continuous zeolite-based separations processes. For such purposes, the natural configuration of the zeolite material is in the form of a thin film or membrane supported on, or deposited in, a porous substrate. A wellfabricated zeolite membrane would be expected to behave as a continuous separation device, with reasonably high selectivity and flux. Many separations that are currently carried out using distillation, crystallization, and other conventional processes can be carried out with a much less energy-intensive zeolite membrane-based separation process. The widely exploited catalytic properties of zeolitic materials also imply the possibility of catalytic membrane reactor processes, combining selective catalysis with selective separations.
Cryptographic Algorithms and Key Sizes for Personal Identity Verification (2015)

44 U.S.C. § 3541 et seq., Public Law (P.L.) 113-283.NIST is responsible for developing information security standards and guidelines, including
Manganous Complexes of Several Amino Acids<sup>1</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTManganous Complexes of Several Amino Acids1Harry KrollCite this: J. Am. Chem. Soc. 1952, 74, 8, 2034–2036Publication Date (Print):April 1, 1952Publication History Published online1 May 2002Published inissue 1 April 1952https://pubs.acs.org/doi/10.1021/ja01128a050https://doi.org/10.1021/ja01128a050research-articleACS PublicationsRequest reuse permissionsArticle Views253Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation (2013)

Reducing hepatic iron deposition and CO levels by inhibiting HO-1 activity though the Nrf2/Keap pathway could be helpful in improving hepatic fibrosis and regulating PVP.
Language models for financial news recommendation (2000)

g fc 3 & 2$ gV pV p 1 2 eC6 C 2V Gc % 2g 3 V p 8 8 9 c 8V p W 2 8 c 8 & 2@ A 8 dU " 8 t ' A 9 ' 8$ g fc FU 7 ' 9 # F #9 # TV p$ 31 U 8c Q g 'U 8 F ' 8$ # fY 1. INTRODUCTION h
CASZ1 inhibits cell cycle progression in neuroblastoma by restoring pRb activity (2013)

Dysregulation of cell cycle genes such as Cyclin D1 and Chk1 contributes to the undifferentiated phenotype of neuroblastoma (NB). CASZ1 functions as a tumor suppressor in NB; here we sought to determine how loss of CASZ1 contributes to cell cycle dysregulation in NB. CASZ1 restoration in NB cells delays NB cell cycle progression. The earliest changes occur within 8 h of CASZ1 restoration in SY5Y cells with a 2.8-fold increase in the level of p21, an inhibitor of Cdk2/4. By 16 h, there is a 40% decrease in the steady-state levels of Cdk6. Restoration of CASZ1 decreases Cdk2-dependent cyclins A and E protein levels and Cdk4/6-dependent Cyclin D1 protein levels. The restoration of CASZ1 resulted in a decrease in pRb phosphorylation and a significant reduction of E2F transcriptional activity. Subsequent to the changes in the G 1/S transition, induction of CASZ1 results in a decrease in Cyclin B levels and Cdc25c phosphatase levels, an upstream activator of the G 2/M regulator CyclinB:Cdk1. In addition, induction of CASZ1 results in a decrease in the levels of phospho-Chk1, a key M-phase regulatory kinase. Similar results were found in a NB cell line with MYCN amplification. Taken together, this study indicates that restoration of CASZ1 activates pRb in G 1 and inhibits the G 2/M regulators Cyclin B1 and Chk1, leading to a lengthening of NB cell cycle progression and a subsequent decrease in cell proliferation.
Elimination of Remaining Undifferentiated Induced Pluripotent Stem Cells in the Process of Human Cardiac Cell Sheet Fabrication Using a Methionine-Free Culture Condition (2014)

Cardiac tissue engineering is a promising method for regenerative medicine. Although we have developed human cardiac cell sheets by integration of cell sheet-based tissue engineering and scalable bioreactor culture, the risk of contamination by induced pluripotent stem (iPS) cells in cardiac cell sheets remains unresolved. In the present study, we established a novel culture method to fabricate human cardiac cell sheets with a decreased risk of iPS cell contamination while maintaining viabilities of iPS cell-derived cells, including cardiomyocytes and fibroblasts, using a methionine-free culture condition. When cultured in the methionine-free condition, human iPS cells did not survive without feeder cells and could not proliferate or form colonies on feeder cells or in coculture with cells for cardiac cell sheet fabrication. When iPS cell-derived cells after the cardiac differentiation were transiently cultured in the methionine-free condition, gene expression of OCT3/4 and NANOG was downregulated significantly compared with that in the standard culture condition. Furthermore, in fabricated cardiac cell sheets, spontaneous and synchronous beating was observed in the whole area while maintaining or upregulating the expression of various cardiac and extracellular matrix genes. These findings suggest that human iPS cells are methionine dependent and a methionine-free culture condition for cardiac cell sheet fabrication might reduce the risk of iPS cell contamination.
Electric field effects on biphenyl smectic <i>A</i> liquid crystals (1974)

Generally, smectic liquid crystals do not exhibit any effects when electric fields are applied. We report here a new alignment effect in a smectic A liquid crystal due to an ac electric field. This effect has been observed on several biphenyl smectic A liquid crystals. Results for the focal conic to homeotropic transition in the smectic phase are given. Several parameters-temperature, voltage, and frequency-are discussed.
First‐pass metabolism of acetaminophen in rats after low and high doses (1990)

The first-pass metabolism of acetaminophen was examined in rats after the administration of 15, 30, 150, and 300 mg kg-1 doses by intra-arterial, intravenous, portal vein, and oral routes. Plasma concentrations of acetaminophen and its two major metabolites, acetaminophen glucuronide and acetaminophen sulfate, were measured for about 5 h after drug administration. The first-pass effect after oral administration (oral extraction) was extensive (Eo = 0.34-0.50) at all doses administered. Calculation of the relative contribution of the gastrointestinal tract, liver, and lung to the oral extraction of acetaminophen indicated that the major contribution was due to the gastrointestinal tract at all doses studied (Eg = 0.33-0.50). At higher doses (150 and 300 mg kg-1) clearance was lower possibly due to the saturation of acetaminophen sulfate formation. However, even at these high doses, the contribution of the gastrointestinal mucosa to the oral extraction remained unchanged. Therefore, it appears that the apparent dose-dependent characteristics of acetaminophen metabolism may be due to the saturation of acetaminophen sulfate formation in the liver.
<title>Overview of reticle enhancement technology software strategy</title> (2000)

Although RET software technology has made great advances in recent years, very little attention has been paid to how this technology can be put into reliable and efficient use in a production environment. To stimulate EDA suppliers to take up this task, a system for not only automating RET, but also for generalizing the automation of RET is described.
Higher Oxidation States of Silver. (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleHigher Oxidation States of Silver.J. A. McMillanCite this: Chem. Rev. 1962, 62, 1, 65–80Publication Date (Print):February 1, 1962Publication History Published online1 May 2002Published inissue 1 February 1962https://pubs.acs.org/doi/10.1021/cr60215a004https://doi.org/10.1021/cr60215a004research-articleACS PublicationsRequest reuse permissionsArticle Views1957Altmetric-Citations167LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Studies on the Constituents of Aceraceae Plants. XIII. Diarylheptanoids and Other Phenolics from Acer nikoense. (1996)

From a mixture of the bark and twigs of Acer nikoense MAXIM. (Aceraceae), nine compounds (1-9) were newly isolated. Compound 1 was identical with acerogenin E, and compounds 8 and 9 were β-orcinol derivatives. Acerogenin K (2), a new diarylheptanoid of the cyclic diphenyl type, yielded acerogenin E on oxidation. Acerogenins F (3) through L (7) are new diarylheptanoids of the cyclic biphenyl ether type, whose skeletons and substituents of the diphenyl ether moieties are the same as those of acerogenin A. Their structures were elucidated on the basis of chemical and spectroscopic evidence.
A novel domain in the CD30 cytoplasmic tail mediates NFkappaB activation. (1998)

About 100 amino acid residues in the C-terminal region are conserved among human, rat and murine CD30, a member of the tumor necrosis factor receptor (TNFR) superfamily, and can be separated into three subdomains with relatively higher conservation (D1, D2 and D3). Activation of NFkappaB by CD30 was shown to be mediated through interaction of TNFR-associated factor (TRAF) 1, 2 and 5 with the D2 and D3 subdomains. However, the function of the other conserved subdomain, D1, remained to be determined. Deletion of the D2 and D3 subdomains abolished interactions with TRAF2 and 5 but it did not affect NFkappaB activation. Reporter gene assays using deletion and mutant constructs of CD30 revealed that the D1 subdomain is sufficient for NFkappaB activation, without interaction with TRAF2 or 5, and that each subdomain alone can activate NFkappaB. Electrophoretic mobility shift assays revealed constitutive and CD30-induced NFkappaB activation in stable transformants of 293 cells expressing CD30 or a deletion mutant lacking D2 and D3 subdomains. Deletion of C-terminal 19 amino acid residues of the D1 subdomain abolished activation of NFkappaB. Substitution of alanine for one of the two threonine residues (amino acid position 524 and 529), one of which is a potential phosphorylation site in the D1 subdomain, also abolished the NFkappaB activation. Overexpression of the TRAF domain of TRAF2 or 5 had a dominant negative effect on the NFkappaB activation mediated by the D1 subdomain, thereby suggesting involvement of TRAF proteins in the signaling. Thus, the C-terminal 100 amino acid region of CD30 is composed of three independent functional subdomains, two of which contain binding sites for TRAF proteins. A novel domain in the cytoplasmic tail mediates NFkappaB activation, without direct interaction of TRAF2 or 5. Our observations suggest involvement of an unknown TRAF protein(s) in the signal transduction pathway of CD30.
Semiconducting wafer form shaping with an electric discharge machine (1988)

Gallium can be used as a temporary glue for semiconducting wafer mounting. The good electric contact between the electrode, the gallium layer, and the semiconducting wafer makes the spark cutting and the semiconducting wafer form shaping much easier. After wafer spark cutting, the residual gallium can be easily removed by a cotton swab from the surface of the wafer in warm isopropyl alcohol (IPA). Also, in this report, improved circuitry of the electric discharge machine for easy and economical construction is described. Gallium arsenide wafers have been form shaped by the present method.
Big Brother, erm Data is Watching and We Don’t Seem to Care. (2019)

First-place winner in the Academic Category of the 2019 Emerging Writers Contest. The essay examines the problems of data collection and privacy.
Dynamic Endothelialization of Aortic Heart Valve Scaffolds (2012)

Cardiovascular disease is the number one killer worldwide affecting both the heart and blood vessels. Valvular heart disease can arise from calcification, and structural deterioration resulting in a stenotic or regurgitant valve incapable of proper function. With approximately 275,000 valve replacements performed annually worldwide, the need for replacement heart valves is well established. Currently, treatment of valvular heart disease is limited to two options (mechanical and bioprosthetic). Both replacement valves have their own drawbacks, which have driven research in the bioengineering field to focus on the development of a tissue engineered heart valve (TEHV) capable of growth and self-repair. A major hurdle in the creation of a viable TEHV lies in the need for a confluent surface layer of endothelial cells (EC) prior to implantation. ECs are needed in TEHVs because they provide a natural non-thrombogenic surface, and a permeability barrier between blood and the vessel wall. One major step in the TEHV paradigm lies in the development of a means for delivering cells to a heart valve scaffold with the purpose of achieving this confluent cell layer. As it stands now there is no recognized standard for EC seeding, though researchers have developed a number of different devices and protocols attempting to successfully achieve uniform cellular attachment. The goal of this Master's thesis research was to design and create a dynamic cell-seeding device capable of seeding cells onto the surface of a decellularized porcine aortic heart valve scaffold. Once developed, the dynamic seeding device was to be used to create a protocol for optimizing cellular attachment and confluence on the heart valve surface. Additionally, following cell seeding, the next step in the TEHV paradigm is mechanical preconditioning prior to functional implantation. Utilizing a pulsatile heart valve bioreactor, seeded scaffolds were subjected to mechanical forces for the purpose of studying cellular retention and the effects of mechanical stimuli on cell morphology. Analysis of cellular attachment, retention, and viability was done through the use of Live/Dead Assay and Scanning Electron Microscopy (SEM). The results of both Live/Dead and SEM showed that the dynamic seeding device is capable of seeding porcine aortic endothelial cells onto the surface of aortic heart valve scaffolds and that the cells could be retained on the surface after undergoing physiologic bioreactor conditioning. The cells were found to respond to the conditioning, changing morphology and aligning in response to these mechanical forces.
New dielectric barrier for damascene Cu interconnection: trimethoxysilane-based SiO/sub 2/ film with k=3.9 (2001)

We have developed a new Cu-barrier dielectric film suitable for Cu/low-k integration. The film has an SiO/sub 2/ composition and is deposited using trimethoxysilane and N/sub 2/O chemistry. The Cu barrier properties of the film are as good as those of the conventional barrier material (P-SiN). The dielectric constant (k) of the film is 3.9, which is about half the dielectric constant of P-SiN film (k=17.5). The new film has been successfully integrated into damascene Cu interconnections as a Cu cap-layer material. The Cu interconnections had remarkably low line-to-line leakage current (<10 pA/cm/sup 2/) and sufficient dielectric breakdown lifetime under normal operating conditions.
An autoclavable glucose biosensor for microbial fermentation monitoring and control (1995)

The design, construction, and characterization of a prototype-regenerable glucose biosensor based on the reversible immobilization of glucose oxidase (GOx) using cellulose binding domain (CBD) technology is described. GOx, chemically linked to CBD, is immobilized by binding to a cellulose matrix on the sensor-indicating electode. Enzyme immobilization can be reversed by perfusing the cellulose matrix with a suitable eluting solution. An autocavable sensor membrane system is employed which is shown to be practical for use in real microbial fermentations. The prototype glucose biosensor was used without failure or deterioration during fed-batch fermentations of Escherichia coli reaching a maximum cell density of 85 g (dry weight)/L. Medium glucose concentration based on sensor output correlated closely with off-line glucose analysis and was controlled manually at 0.44 +/- 0.2 g/L for 2 h based on glucose sensor output. The sensor enzyme component could be eluted and replaced without interrupting the fermentation. To our knowledge, no other in situ biosensor has been used for such an extended period of time in such a high-cell-density fermentation.
Theory of Reflectance and Emittance Spectroscopy (1993)

This book is aimed at students and researchers who wish to use reflectance and emittance as quantitative tools to measure the properties of surfaces and materials. It is intended primarily for use in the interpretation of remote observations of the surfaces of the Earth and other planets, and it will also be useful to chemists, physicists, geologists, engineers and others who deal with particulate media. Topics include propagation and absorption of light in continuous media, reflection by smooth surfaces, scattering by spheres and irregular particles, reflectances and emissivities of particulate media, reflectance and emittance spectroscopy, and the polarization of light scattered by particulate media. Many examples of applications are given.
Automated mapping of large binary objects using primitive fragment type classification (2010)

Security analysts, reverse engineers, and forensic analysts are regularly faced with large binary objects, such as executable and data files, process memory dumps, disk images and hibernation files, often Gigabytes or larger in size and frequently of unknown, suspect, or poorly documented structure. Binary objects of this magnitude far exceed the capabilities of traditional hex editors and textual command line tools, frustrating analysis. This paper studies automated means to map these large binary objects by classifying regions using a multi-dimensional, information-theoretic approach. We make several contributions including the introduction of the binary mapping metaphor and its associated applications, as well as techniques for type classification of low-level binary fragments. We validate the efficacy of our approach through a series of classification experiments and an analytic case study. Our results indicate that automated mapping can help speed manual and automated analysis activities and can be generalized to incorporate many low-level fragment classification techniques.
Correcting direct effects of ethanol on translation and transcription machinery confers ethanol tolerance in bacteria (2014)

The molecular mechanisms of ethanol toxicity and tolerance in bacteria, although important for biotechnology and bioenergy applications, remain incompletely understood. Genetic studies have identified potential cellular targets for ethanol and have revealed multiple mechanisms of tolerance, but it remains difficult to separate the direct and indirect effects of ethanol. We used adaptive evolution to generate spontaneous ethanol-tolerant strains of Escherichia coli, and then characterized mechanisms of toxicity and resistance using genome-scale DNAseq, RNAseq, and ribosome profiling coupled with specific assays of ribosome and RNA polymerase function. Evolved alleles of metJ, rho, and rpsQ recapitulated most of the observed ethanol tolerance, implicating translation and transcription as key processes affected by ethanol. Ethanol induced miscoding errors during protein synthesis, from which the evolved rpsQ allele protected cells by increasing ribosome accuracy. Ribosome profiling and RNAseq analyses established that ethanol negatively affects transcriptional and translational processivity. Ethanol-stressed cells exhibited ribosomal stalling at internal AUG codons, which may be ameliorated by the adaptive inactivation of the MetJ repressor of methionine biosynthesis genes. Ethanol also caused aberrant intragenic transcription termination for mRNAs with low ribosome density, which was reduced in a strain with the adaptive rho mutation. Furthermore, ethanol inhibited transcript elongation by RNA polymerase in vitro. We propose that ethanol-induced inhibition and uncoupling of mRNA and protein synthesis through direct effects on ribosomes and RNA polymerase conformations are major contributors to ethanol toxicity in E. coli, and that adaptive mutations in metJ, rho, and rpsQ help protect these central dogma processes in the presence of ethanol.