gebhart/patrepeval huggingface dataset:
Autofeedback of Prolactin in Cultured Prolactin-Secreting Pituitary Cells (1980)

Cultured GH3 rat pituitary tumor cells which secrete prolactin (PRL) were used to study autoregulation of rat PRL (rPRL) secretion. Acute (1 h) release of rPRL by cells in monolayer culture was inhibited by ovine PRL (oPRL; 10(-7) and 10(-8) M). Intracellular rPRL accumulation was not inhibited by exogenous oPRL. No effect of oPRL was seen during long-term (12-day) incubation of cells with oPRL (10(-7) to 10(-9) M). oPRL exerts an acute suppressive effect on rPRL release at the cellular level, but does not inhibit rPRL synthesis or long-term release.
Embodied mood regulation: the impact of body posture on mood recovery, negative thoughts, and mood-congruent recall (2016)

Previous work has shown that a stooped posture may activate negative mood. Extending this work, the present experiments examine how stooped body posture influences recovery from pre-existing negative mood. In Experiment 1 (n = 229), participants were randomly assigned to receive either a negative or neutral mood induction, after which participants were instructed to take either a stooped, straight, or control posture while writing down their thoughts. Stooped posture (compared to straight or control postures) led to less mood recovery in the negative mood condition, and more negative mood in the neutral mood condition. Furthermore, stooped posture led to more negative thoughts overall compared to straight or control postures. In Experiment 2 (n = 122), all participants underwent a negative mood induction, after which half received cognitive reappraisal instructions and half received no instructions. Mood-congruent cognitions were assessed through autobiographical memory recall. Again, stooped (compared to straight) position led to less mood recovery. Notably, this was independent of regulation instruction. These findings demonstrate for the first time that posture plays an important role in recovering from negative mood.
Cholinium‐based Supported Ionic Liquid Membranes: A Sustainable Route for Carbon Dioxide Separation (2013)

Abstract Aiming at full sustainability of CO 2 separation processes, a series of supported ionic liquid membranes based on environmentally friendly cholinium carboxylate ionic liquids were successfully prepared. Their gas permeation properties were measured and high permselectivities were obtained for both CO 2 /CH 4 and CO 2 /N 2 .
Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. (1993)

The present study was conducted to examine the effect of activin A on growth of rat hepatocytes. EGF induced a 10-fold increase in DNA synthesis as assessed by [3H]thymidine incorporation in cultured hepatocytes. When activin A was added together with EGF, DNA synthesis induced by EGF was markedly inhibited. Inhibition was detected at a concentration of 10(-10) M, and 5 x 10(-9) M activin A almost completely blocked EGF-mediated DNA synthesis. Similarly, activin A completely blocked DNA synthesis induced by hepatocyte growth factor/scatter factor. Activin A was capable of inhibiting EGF-mediated DNA synthesis, even when added 36 h after the addition of EGF. With the same time interval, TGF-beta also blocked EGF-induced DNA synthesis. Although both activin A and TGF-beta inhibited growth of hepatocytes in a similar manner, either activin A or TGF-beta did not compete with each other in their binding when assessed by competitive binding using an iodinated ligand. When hepatocytes were incubated with EGF, release of bioactivity of activin A into culture medium was detected after 48 h or later. Activity of activin A was released from parenchymal cells but not from nonparenchymal cells. mRNA for beta A subunit of activin was detected only slightly in unstimulated hepatocytes, but markedly increased at 48 h after the addition of EGF. To determine whether endogenously produced activin A affects DNA synthesis, we examined the effect of follistatin, an activin-binding protein that blocks the action of activin A. An addition of follistatin significantly enhanced EGF-induced DNA synthesis. Finally, in partial hepatectomized rat, expression of mRNA for beta A subunit in liver was markedly increased 24 h after the partial hepatectomy. These results indicate that activin A inhibits initiation of DNA synthesis in hepatocytes by acting on its own receptor and that activin A acts as an autocrine inhibitor of DNA synthesis in rat hepatocytes.
Probing the Role of Poly(3,4-ethylenedioxythiophene)/Poly(styrenesulfonate)-Coated Multiwalled Carbon Nanotubes in the Thermal and Mechanical Properties of Polycarbonate Nanocomposites (2014)

The role played by multiwalled carbon nanotubes (MWCNTs) coated with poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) in the thermal and mechanical properties of polycarbonate (PC) nanocomposites was analyzed. We used differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) to demonstrate that the glass transition temperature of polycarbonate nanocomposites decreased whereas the storage modulus of the samples increased by including PEDOT/PSS-coated MWCNTs. These results indicated that PEDOT/PSS acts as an antiplasticizer. We attributed the enhancement of the storage modulus to the strong hydrogen bonding between PSS and the PC matrix and the reduction of the free volume in the PC matrix due to the shrinkage of PEDOT/PSS upon heating. We also investigated changes in the thermal conductivity and thermal degradation behavior of the nanocomposites. The results indicated that PEDOT/PSS did not play a significant role in improving the thermal conductivity and thermal stability of PC nanocomposites. The relative improvements in the conductivity and thermal stability of the samples that contained PEDOT/PSS were attributed to the better dispersion of the MWCNTs in the PC matrix.
Design and Development of an acoustic positioning system for a cubic kilometre underwater neutrino telescope (2012)

In this thesis the work and the results for designing, developing, testing and characterizing a prototype of acoustic transceiver to be used in the APS of the future KM3NeT neutrino telescope are presented.
In Situ Neutron Diffraction Analysis of Phase Transformation Kinetics in TRIP Steel (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Airborne Base Stations for Emergency and Temporary Events (2013)

This paper introduces a rapidly deployable wireless network based on Low Altitude Platforms and portable land units to support disaster-relief activities, and to extend capacity during temporary mass events. The system integrates an amalgam of radio technologies such as LTE, WLAN and TETRA to provide heterogeneous communications in the deployment location. Cognitive radio is used for autonomous network configuration. Sensor networks monitor the environment in real-time during relief activities and provide distributed spectrum sensing capacities. Finally, remote communications are supported via S-band satellite links.
The solution of nonlinear finite element equations (1979)

Abstract An algorithm is described which appears to give an efficient solution of nonlinear finite element equations. It is a quisi‐Nowton method, and we compare it with some of the alternatives. Initial tests of its application to both material and geometric nonlinearities are discussed.
Influenza M2 virus-like particle vaccination enhances protection in combination with avian influenza HA VLPs (2019)

Despite the ability to induce a broad range of cross protection, M2e5x virus-like particles (VLPs) alone provide limited vaccine efficacy and confer low efficacy of protection against highly pathogenic avian influenza virus (HPAIV) infection in chickens. Avian influenza hemagglutinin (HA) has been a major antigenic target that enhances humoral immunity, but the efficacy of avian HA-based vaccines against HPAIV needs to be further improved. In this study, we evaluated the vaccine efficacy induced by combination of conserved tandem repeat M2e5x VLPs and HA VLPs against an avian influenza virus. We found that combinatorial vaccine elicited higher levels of reassortant H5N1 (rgH5N1) virus-specific IgG, IgG1, IgG2a and IgA antibody responses compared to M2e5x VLPs in sera and lungs of mice. Combinatorial VLPs vaccination induced higher levels of CD8+ T cell and germinal center B cell responses in lung and spleen compared to M2e5x VLPs. Combinatorial VLPs vaccination showed significantly reduced inflammatory responses and lung viral loads upon rgH5N1 virus challenge infection, resulting in less body weight loss compared to M2e5x VLPs alone. These results indicate that immune responses to both M2e and HA might provide a strategy of vaccination inducing enhanced protection against avian influenza virus.
Selective Agents for Serotonin2C (5-HT2C) Receptor (2006)

The serotonin2C (5-HT2C) receptor has attracted a lot of attention owing to its role in appetite regulation, depression, obsessive-compulsive disorder (OCD), panic disorders, and substance abuse. This review summarizes nonpatent and patent literature up to November 2005 that deals with the synthesis and characterization of selective 5-HT2C receptor agonists and antagonists. Highlights on structure-activity relationships have been included, when possible. Keywords: CYP1A2, mCPP, RO600175, anxiolytic, WAY-629, phenylpiperazine
Sharing Aggregate Computation of Multiple Group by Queries over Distributed Data Stream (2008)

Data streaming systems are becoming essential for monitoring applications such as financial analysis, network intrusion detection and sensor network. These systems often have to process multiple similar but different continuous aggregation queries simultaneously. Since executing each query separately can lead to significant scalability and performance problems, it is vital to share resources by exploiting similarities in the queries. The challenge is to identify overlapping computations that may not be obvious in the queries themselves. In this paper, we reveal new opportunities for sharing work in the context of distributed aggregation queries that vary in their group by predicates. We identify settings in which a large set of m such queries can be answered by executing n< m different queries. The n queries are revealed by analyzing the binary two-dimension array capturing the connection among the queries that they satisfy. We propose a novel algorithmic solution for problem of finding the minimum number of queries in such a distributed-streams setting, in order to optimize the communicate cost across the network. The experiment result show that our approach gives us as much as magnitude performance improvement over the no-share settings.
The use of the air pouch to study experimental synovitis and cartilage breakdown. (1986)

This mini-review outlines the development and application of the air pouch model during the past five years. It shows the importance of using the appropriate aged pouch to establish long-lasting chronic inflammation following immune and non-immune stimuli. Subsequently, the effects of different inflammatory environments were studied on implanted cartilage. It has been found that the inflammation used to date did not lead to an appreciable increase in the rate of cartilage degradation. This is discussed with the implications for new trends in therapeutic research applied to rheumatology.
A redundant gateway prototype for wireless avionic sensor networks (2017)

Wireless Sensor Network (WSN) technologies provide advantages that allow them to replace traditional wired systems in an ever growing number of applications. This paper describes the design of a WSN for mission critical applications such as the case of avionics, in which data collected from the sensors can be delivered to a cloud application through multiple independent gateways, thereby increasing data availability in presence of failures. Since the same data might be distributed along multiple paths, system-wide synchronization must be provided in order to guarantee data consistency. A heartbeat protocol is introduced along each path in order to guarantee timely detection of any single failure. We present a solution that can be implemented using open source software and commercial off-the-shelf hardware, which makes this approach viable for networks with a large number of heterogeneous sensors. Results reported in this paper show some sample measurements as well as the performance evaluation for our heartbeat algorithm in terms of latency between a failure and a full recovery of the system.
Detecting Falls with Wearable Sensors Using Machine Learning Techniques (2014)

Falls are a serious public health problem and possibly life threatening for people in fall risk groups. We develop an automated fall detection system with wearable motion sensor units fitted to the subjects' body at six different positions. Each unit comprises three tri-axial devices (accelerometer, gyroscope, and magnetometer/compass). Fourteen volunteers perform a standardized set of movements including 20 voluntary falls and 16 activities of daily living (ADLs), resulting in a large dataset with 2520 trials. To reduce the computational complexity of training and testing the classifiers, we focus on the raw data for each sensor in a 4 s time window around the point of peak total acceleration of the waist sensor, and then perform feature extraction and reduction. Most earlier studies on fall detection employ rule-based approaches that rely on simple thresholding of the sensor outputs. We successfully distinguish falls from ADLs using six machine learning techniques (classifiers): the k-nearest neighbor (k-NN) classifier, least squares method (LSM), support vector machines (SVM), Bayesian decision making (BDM), dynamic time warping (DTW), and artificial neural networks (ANNs). We compare the performance and the computational complexity of the classifiers and achieve the best results with the k-NN classifier and LSM, with sensitivity, specificity, and accuracy all above 99%. These classifiers also have acceptable computational requirements for training and testing. Our approach would be applicable in real-world scenarios where data records of indeterminate length, containing multiple activities in sequence, are recorded.
Glycodiversification for the Optimization of the Kanamycin Class Aminoglycosides (2005)

In an effort to optimize the antibacterial activity of kanamycin class aminoglycoside antibiotics, we have accomplished the synthesis and antibacterial assay of new kanamycin B analogues. A rationale-based glycodiversification strategy was employed. The activity of the lead is comparable to that of commercially available kanamycin. These new members, however, were found to be inactive against aminoglycoside resistant bacteria. Molecular modeling was used to provide the explanation. Thus, a new strategy for structural modifications of kanamycin class aminoglycosides is suggested.
An Optical Biosensor for Monitoring Antigen Recognition Based on Surface Plasmon Resonance Using Avidin-Biotin System (2001)

A novel optical biosensor based on simultaneous multiwave length detection surface plasmon resonance (SPR) has been developed for immunosensing. The sensor is designed on the basis of fixing angle of incidence and measuring the reflected intensities of light in the wavelength range of 400–800 nm. The SPR spectra are shown in terms of reflected light intensity verus wavelength of incident light. The intensity of the reflected light is the minimum at the resonant wavelength. The biorecognition surface, formed on a chemically modified gold layer, consists of avidin that is specifically bound with biotin. These sensing membranes were self-assembled on gold layer. The processes of sensing monolayer formation were studied in real time through observing the change of resonant wavelength. The modified surface was used as a model immunosensor and to detect successfully the human factor B (Bf). The Bf was determined in the concentration range of 0.5~100 μg/mL. Under optimum experimental conditions, the sensor has a good repeatability, reversibility and selectivity.
ATR, Claspin and the Rad9-Rad1-Hus1 Complex Regulate Chk1 and Cdc25A in the Absence of DNA Damage (2004)

The ATR and Chk1 kinases are essential to maintain genomic integrity. ATR, with Claspin and the Rad9-Rad1-Hus1 complex, activates Chk1 after DNA damage. Chk1-mediated phosphorylation of the Cdc25A phosphatase is required for the mammalian S-phase checkpoint. Here, we show that during physiological S phase the regulation of the Chk1-Cdc25A pathway depends on ATR, Claspin, Rad9, and Hus1. Human cells with chemically or genetically ablated ATR showed inhibition of Chk1-dependent phosphorylation of Cdc25A, and they accumulated Cdc25A without external DNA damage. Furthermore, siRNA-mediated depletion of Claspin, Rad9 and Hus1 also stabilized Cdc25A. ATR ablation also inhibited the activatory phosphorylation of Chk1 on serine 345. Thus, the ATR-Chk1-Cdc25A pathway represents an integral part of physiological S-phase progression, and interference with this mechanism undermines viability of somatic mammalian cells. DNA damage further activates and switches this pathway from its constitutively operating "surveillance mode" compatible with DNA replication into an "emergency" checkpoint response.
Invited: Solid State Image Sensors Using the Charge Transfer Principle (1977)

A new type of charge transfer sensor, the resistive gate sensor will be described. This resistive gate sensor is compared with existing charge transfer sensors. The comparison is favorable for the resistive gate sensor with respect to point anti-blooming, the sensitivity to blue light and the overall sensitivity. A lot of work has still to be done to show whether this sensor is a practical proposition for consumer applications.
Enteral administration of recombinant erythropoietin to preterm infants. (1996)

In six preterm infants we tested the hypothesis that, as is the case in infant rats, orally administered recombinant erythropoietin (EPO) would be absorbed and would stimulate erythropoiesis. Three study subjects were younger than 1 week old and had never been fed and three were more than 1 month old and were receiving enteral feedings totally. Two hours after the administration of large doses of EPO (1000 U/kg body weight) only a small increase in serum EPO concentrations (from 6.3 +/- 0.9 to 13.3 +/- 2.8 mU/ml, mean +/- SEM) was observed. No further increases were observed 4, 6, 12, or 24 hours after the administration. No increases in reticulocyte count or hematocrit were observed after 10 days of EPO administration. We conclude that, unlike the situation in infant rats, enterally administered recombinant EPO is not absorbed in significant amounts by human preterm infants. Therefore oral administration will not be an effective substitute for subcutaneous or intravenous EPO administration in preterm infants.
Anti-HIV Bioactive Stilbene Dimers of<i>Caragana rosea</i> (2005)

Bioassay-guided fractionation of the ethanol extract of the aerial parts of Caragana rosea Turcz. led to the isolation of two new (cararosinol C and cararosinol D) and four known [scirpusin A (1), cis-scirpusin A (2), maackin (3), scirpusin B (4)] stilbene dimers. This is the first identification of these compounds from this plant and the first time that compound 2 has been isolated as a natural compound. Their structures were established mainly by spectral means. An in vitro assay against HIV-1 (IIIB), demonstrated compounds 1 and 4 to be active against HIV, with EC50 values of 10 microg/mL and 7 microg/mL respectively.
DRAM Package Substrate Using Via Cutting Structure (2011)

A new via cutting structure in 2-layer DRAM package substrate has been fabricated to lower its power distribution network(PDN) impedance. In new structure, part of the via is cut off vertically and its remaining part is designed to connect directly with the bonding pad on the package substrate. These via structure and substrate design not only provide high routing density but also improve the PDN impedance by shortening effectively the path from bonding pad to VSSQ plane. An additional process is not necessary to fabricate the via cutting structure because its structure is completed at the same time during a process of window area formation. Also, burr occurrence is minimized by filling the via-hole inside with a solder resist. 3-dimensional electromagnetic field simulation and S-parameter measurement are carried out in order to validate the effects of via cutting structure and VDDQ/VSSQ placement on the PDN impedance. New DRAM package substrate has a superior PDN impedance with a wide frequency range. This result shows that via cutting structure and power/ground placement are effective in reducing the PDN impedance.
Crossover in the adsorption properties of alkali metals on graphene (2010)

The adsorption of alkali metals (AMs) on single layer graphene is studied using first principles methods. We observe a common trend in the binding distance, the charge transfer, and the work function $(W)$ at certain coverage of AMs with increase in the proportion $\ensuremath{\rho}$ (adatom/C atom) of the graphene covered by the AM. A dip in these properties occurs at $\ensuremath{\rho}\ensuremath{\approx}0.04$ for all AMs except Li, for which it occurs at $\ensuremath{\rho}\ensuremath{\approx}0.08$. This behavior is due to a transition of adsorbed metals from individual atoms to two-dimensional metallic sheets that exert a depolarization effect. $W$ of graphene exhibits asymmetric dependence on $\ensuremath{\rho}$: a dip in the adatom layer side but saturation on the graphene side, which is in contrast to the case of bulk graphite.
Training, Satisfaction with Internship Programs, and Confidence about Future Careers among Hospitality Students: A Case Study of Universities in Taiwan (2008)

ABSTRACT The purpose of this research is to investigate the factors associated with hospitality students' satisfaction with internship programs and the relationships between training, job satisfaction, and confidence about future careers in order to provide schools and industries with suggestions regarding course development and training during internships. A principal component analysis was used to determine the degree of satisfaction with the supervisor, the educational program, the environment, the administration, and relationships. Training classes made a significant difference in satisfaction with the supervisor and educational program. The regression analysis showed that training satisfaction played a positive role as a predictor of participants' job satisfaction and confidence about future careers. The effect of satisfaction with training on participants' confidence about future careers was mediated by their satisfaction with the internship. The administration and learning factors in connection with participants' satisfaction during the internship were found to be significant predicators of their confidence about future careers, but supervision, environment, and interpersonal relations were not.