gebhart/patrepeval huggingface dataset:
Evaluating degrees of tenant isolation in multitenancy patterns: A case study of cloud-hosted Version Control System (VCS) (2015)

One of the key concerns of implementing multitenancy (i.e., serving multiple tenants with a single instance of an application) on the cloud is how to enable the required degree of isolation between tenants, so that the required performance of one tenant does not affect other tenants. There is little research which provides empirical evidence on the required degree of isolation between tenants under different cloud deployment conditions. This paper applies COMITRE (COmponent-based approach to Multitenancy Isolation Through request RE-routing) to empirically evaluate the degree of isolation between tenants enabled by multitenancy patterns for cloud-hosted Version Control System (VCS). We implemented three multitenancy patterns (i.e., shared component, tenant-isolated component, and dedicated component) by developing a multitenant component using the FileSystem SCM plugin integrated within Hudson. The study revealed that dedicated component provides the highest degree of isolation between tenants (compared to shared component and tenant-isolated component) in terms of error% (i.e., the percentage of errors with unacceptably slow response times) and throughput. System load of tenants showed no variability, and hence did not influence the degree of tenant isolation for all the three multitenancy patterns. We also provide some recommendations to guide an architect in implementing multitenancy isolation on similar VCS tools like Subversion and CVS.
A Dynamic Path Planning Method for Social Robots in the Home Environment (2020)

The home environment is a typical dynamic environment with moveable obstacles. The social robots working in home need to search for feasible paths in this complex dynamic environment. In this work, we propose an improved RRT algorithm to plan feasible path in home environment. The algorithm pre-builds a tree that covers the whole map and maintains the effectiveness of all nodes with branch pruning, reconnection, and regrowth process. The method forms a path by searching the nearest node in the tree and then quickly accessing the nodes near the destination. Due to the effectiveness-maintaining process, the proposed method can effectively deal with the complex dynamic environment where the destination and multiple moving obstacles change simultaneously. In addition, our method can be extended to the path-planning problem in 3D space. The simulation experiments verify the effectiveness of the algorithm.
Phenotypic Profiling of <i>DPYD</i> Variations Relevant to 5-Fluorouracil Sensitivity Using Real-time Cellular Analysis and <i>In Vitro</i> Measurement of Enzyme Activity (2013)

In the 45 years since its development, the pyrimidine analog 5-fluorouracil (5-FU) has become an integral component of many cancer treatments, most notably for the management of colorectal cancer. An appreciable fraction of patients who receive 5-FU suffer severe adverse toxicities, which in extreme cases may result in death. Dihydropyrimidine dehydrogenase (DPD, encoded by DPYD) rapidly degrades 85% of administered 5-FU, and as such, limits the amount of drug available for conversion into active metabolites. Clinical studies have suggested that genetic variations in DPYD increase the risk for 5-FU toxicity, however, there is not a clear consensus about which variations are relevant predictors. In the present study, DPYD variants were expressed in mammalian cells, and the enzymatic activity of expressed protein was determined relative to wild-type (WT). Relative sensitivity to 5-FU for cells expressing DPYD variations was also measured. The DPYD*2A variant (exon 14 deletion caused by IVS14+1G>A) was confirmed to be catalytically inactive. Compared with WT, two variants, S534N and C29R, showed significantly higher enzymatic activity. Cells expressing S534N were more resistant to 5-FU-mediated toxicity compared with cells expressing WT DPYD. These findings support the hypothesis that selected DPYD alleles are protective against severe 5-FU toxicity, and, as a consequence, may decrease the effectiveness of 5-FU an antitumor drug in carriers. In addition, this study shows a method that may be useful for phenotyping other genetic variations in pharmacologically relevant pathways.
Grasping Claws of Bionic Climbing Robot for Rough Wall Surface: Modeling and Analysis (2017)

Aiming at the inspection of rough stone and concrete wall surfaces, a grasping module of cross-arranged claw is designed. It can attach onto rough wall surfaces by hooking or grasping walls. First, based on the interaction mechanism of hooks and rough wall surfaces, the hook structures in claw tips are developed. Then, the size of the hook tip is calculated and the failure mode is analyzed. The effectiveness and reliability of the mechanism are verified through simulation and finite element analysis. Afterwards, the prototype of the grasping module of claw is established to carry out grasping experiment on vibrating walls. Finally, the experimental results demonstrate that the proposed cross-arranged claw is able to stably grasp static wall surfaces and perform well in grasping vibrating walls, with certain anti-rollover capability. This research lays a foundation for future researches on wall climbing robots with vibrating rough wall surfaces.
Automated Visual Inspection: A Survey (1982)

This paper surveys publications, reports, and articles dealing with automated visual inspection for industry. The references are organized according to their contents: overview and discussions, rationales, components and design considerations, commercially available systems, applications. A number of applications and their inspection methodologies are discussed in detail: the inspection of printed circuit boards, photomasks, integrated circuit chips. Other inspection applications are listed as a bibliography. A list of selectively annotated references in commercially available visual inspection tools is also included.
Decreased Nitric-oxide Synthase Activity Causes Impaired Endothelium-dependent Relaxation in the Postischemic Heart (1997)

Endothelial nitric-oxide synthase (eNOS) is an important regulator of endothelial function and vascular tone in biological tissues. While endothelial dysfunction occurs following ischemia and has been attributed to altered NO. formation, the biochemical basis for this dysfunction is unknown. Therefore, studies were performed to determine the effects of myocardial ischemia and reperfusion on eNOS in isolated rat hearts subjected to periods of global ischemia or ischemia followed by reperfusion. eNOS activity was assayed by L-[14C]arginine to L-[14C]citrulline conversion and alterations in the amount and distribution of eNOS determined by Western blotting and immunohistochemistry. While activity was preserved after 30 min of ischemia with a value of 1.1 +/- 0.1 pmol x min-1 x mg of protein-1, it decreased by 77% after 60 min and became nearly undetectable after 120 min. Reperfusion resulted in only a partial restoration of activity. The decline in activity with ischemia was due, in part, to a loss of eNOS protein. Hemodynamic studies showed that the onset of impaired vascular reactivity paralleled the loss of functional eNOS. Subjecting isolated eNOS to conditions of acidosis, which occur during ischemia, followed by restoration of pH as occurs on reperfusion, caused a combination of reversible and irreversible loss of activity similar to that seen in ischemic and reperfused hearts. Thus, loss of endothelial function following ischemia is paralleled by a loss of eNOS activity due to a combination of pH-dependent denaturation and proteolysis.
1'-Methyl- and 1',10-Dimethyl-1,2-benzanthracene (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1'-Methyl- and 1',10-Dimethyl-1,2-benzanthraceneLouis F. Fieser and Arnold M. SeligmanCite this: J. Am. Chem. Soc. 1938, 60, 1, 170–176Publication Date (Print):January 1, 1938Publication History Published online1 May 2002Published inissue 1 January 1938https://pubs.acs.org/doi/10.1021/ja01268a051https://doi.org/10.1021/ja01268a051research-articleACS PublicationsRequest reuse permissionsArticle Views310Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bootstrapped low-voltage analog switches (2003)

Novel low-voltage constant-impedance analog switch circuits are proposed. The switch element is a single MOSFET, and constant-impedance operation is obtained using simple circuits to adjust the gate and bulk voltages relative to the switched signal. Low-voltage (1-volt) operation is made feasible by employing a feedback loop. The gate oxide will not be subject to voltages exceeding the supply voltage difference. Realistic switches have been simulated with HSPICE. The simulations show that the switch circuits operate very well, even when the supply voltage approaches the technology's threshold voltage.
Control of directionality in the site‐specific recombination system of the <i>Streptomyces</i> phage φC31 (2000)

The genome of the Streptomyces temperate phage phiC31 integrates into the host chromosome via a recombinase belonging to a novel group of phage integrases related to the resolvase/invertase enzymes. Previously, it was demonstrated that, in an in vitro recombination assay, phiC31 integrase catalyses integration (attP/attB recombination) but not excision (attL/attR). The mechanism responsible for this recombination site selectivity was therefore investigated. Purified integrase was shown to bind with similar apparent binding affinities to between 46 bp and 54 bp of DNA at each of the attachment sites, attP, attB, attL and attR. Assays using recombination sites of 50 bp and 51 bp for attP and attB, respectively, showed that these fragments were functional in attP/attB recombination and maintained strict site selectivity, i.e. no recombination between non-permissive sites, such as attP/attP, attB/attL, etc., was observed. Using bandshifts and supershift assays in which permissive and non-permissive combinations of att sites were used in the presence of integrase, only the attP/attB combination could generate supershifts. Recombination products were isolated from the supershifted complexes. It was concluded that these supershifted complexes contained the recombination synapse and that site specificity, and therefore directionality, is determined at the level of stable synapse formation.
Organic Photovoltaic Devices Based on Blends of Regioregular Poly(3-hexylthiophene) and Poly(9,9-dioctylfluorene-<i>co</i>-benzothiadiazole) (2004)

We have fabricated organic photovoltaic devices with blends of regioregular poly(3-hexylthiophene) (P3HT) and poly(9,9-dioctylfluorene-co-benzothiadiazole) (F8BT) as an electron donor and an electron acceptor, respectively. Several fabrication parameters such as blend composition, film thickness, solvent, and presence of LiF layer were varied in order to find the maximum device performance. The highest external quantum and power conversion efficiencies were achieved for the blend film with 60 wt % P3HT using p-xylene as a solvent. Insertion of a LiF layer further improved the power conversion efficiency from 0.02% to 0.13% under AM1.5 condition (1 Sun). To understand the relatively poor efficiency even in the optimized device, this polymer blend system was analyzed in relation to the following factors: charge separation efficiency, as measured by photoluminescence quantum efficiency; charge carrier mobility, measured by time-of-flight; and charge recombination dynamics, measured by transient absorption spectroscopy. The results showed that the electron mobility of F8BT is responsible mainly for the low efficiency in the presence of minor contribution of the charge separation efficiency.
Epigenetics and the placenta (2010)

Studies in both animals and humans have made it increasingly clear that proper epigenetic regulation of both imprinted and non-imprinted genes is important in placental development. Its disturbance, which can be caused by various environmental factors, can lead to abnormal placental development and function with possible consequences for maternal morbidity, fetal development and disease susceptibility in later life.
Preparation of carbon coated MoO2 nanobelts and their high performance as anode materials for lithium ion batteries (2012)

Carbon coated MoO2 nanobelts were successfully synthesized via a hydrothermal method followed by calcination under inert atmosphere, using α-MoO3 nanobelts as the precursor and self-template, ethanol as the reducer and glucose as the carbon source. Under the protection of polysaccharide resulting from glucose polycondensation, the 1-D morphology can be well retained during the reduction and carbonization processes. Tested as anode materials for lithium ion batteries, the carbon coated MoO2 nanobelts exhibit a reversible capacity of 769.3 mA h g−1 at a current density of 100 mA g−1 in the first cycle, and retain 80.2% of the capacity after 30 cycles. When the current density increases, this material shows high rate capability and good cycling performance.
Suppression of Resistance to Salmonella typhimurium in Young Chickens Inoculated with Corynebacterium parvum (1989)

The effect of Corynebacterium parvum on resistance to Salmonella typhimurium infection was evaluated in young chickens. One-day-old chickens were inoculated subcutaneously (SC) or intraperitoneally (IP) with 1.4 mg killed C. parvum and challenged by IP injection with 5.0 X 10(7) S. typhimurium 4 days later. Spleen and bursa of Fabricius weights were not altered in the C. parvum-inoculated chickens. A transient increase in thymus weight occurred 3 days after inoculation with C. parvum. Phytohemagglutinin-elicited cutaneous hypersensitivity was significantly suppressed in the C. parvum-inoculated chickens. Morbidity due to Salmonella infection increased significantly from 15% and 21% in the control groups to 43% and 46% in the chickens inoculated IP or SC with C. parvum. The results indicated that inoculation of 1-day-old chickens with C. parvum suppressed cell-mediated immune responsiveness and decreased resistance to peritoneal infection with S. typhimurium.
Design of salt–metal organic framework composites for seasonal heat storage applications (2017)

A series of MOFs–CaCl<sub>2</sub> composite sorbents was developed for seasonal heat storage which combine outstanding energy capacity and cycling stability.
International Direct Real Estate Investment: A Review of the Literature (2003)

This paper provides a critical review of research on international direct real estate investment issues. To date, no review article has explored the various findings of studies completed on the benefits of international real estate diversification. In the past 10 years, the quantity and variety of work have increased dramatically. The paper is organised by how investing in a real estate asset is analysed: in a mixed-asset portfolio context or a real-estate-only portfolio context. A fourth section focuses on research that has explored currency risk, one of the prevailing risks associated with international investing. The last section provides conclusions about the research and offers ideas for future research in this growing area of real estate investment.
Design and Synthesis of Novel <i>N</i>-Acetylgalactosamine-Terminated Glycolipids for Targeting of Lipoproteins to the Hepatic Asialoglycoprotein Receptor (2004)

A novel glycolipid has been prepared that contains a cluster glycoside with an unusually high affinity for the asialoglycoprotein receptor (ASGPr) and a bile acid moiety that mediates stable incorporation into lipidic particles. The glycolipid spontaneously associated with low-density lipoproteins (LDL) and high-density lipoproteins (HDL) within human and murine plasma, and loading of lipoproteins with this glycolipid resulted in an efficient dose-dependent recognition and uptake of LDL and HDL by the liver (and not by spleen) upon intravenous injection into wild-type mice. Preinjection with asialoorosomucoid largely inhibited the uptake, establishing that both HDL and LDL were selectively recognized and processed by the ASGPr on liver parenchymal cells. Finally, repeated intravenous administration of the glycolipid to hyperlipidemic LDL receptor-deficient mice evoked an efficient and persistent cholesterol-lowering effect. These results indicate that the glycolipid may be a promising alternative for the treatment of hyperlipidemic patients who do not respond sufficiently to current cholesterol-lowering therapies.
Synthesis of 4-methylene-1,3-dioxolan-2-one. A bifunctional cyclic carbonate (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 4-methylene-1,3-dioxolan-2-one. A bifunctional cyclic carbonateBarry M. Trost and Dominic M. T. ChanCite this: J. Org. Chem. 1983, 48, 19, 3346–3347Publication Date (Print):September 1, 1983Publication History Published online1 May 2002Published inissue 1 September 1983https://pubs.acs.org/doi/10.1021/jo00167a044https://doi.org/10.1021/jo00167a044research-articleACS PublicationsRequest reuse permissionsArticle Views491Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Wireless transmission system based on nRF401 (2008)

The wireless communication has the important status in modern communication be- cause it dose not need much line and its convenience.This paper designs a wireless transmission system based on the nRF401.It uses wireless transmission to deliver the temperature measured by DS18B20 to the PC machine.At the same time,we utilize the simulating serial port which uses the common I/O to send and receive the data.The system uses VB6.0 to carry out the de- sign of the man-machine interface.It can carry out the manifestation of the temperature data and the related processing according to the interface operation.The practice proves that it is easy in implement,applicable in functions and reliable in operation.
Identification of Transactivation and Repression Functions of the Dioxin Receptor and Its Basic Helix-Loop-Helix/PAS Partner Factor Arnt: Inducible versus Constitutive Modes of Regulation (1994)

Gene regulation by dioxins is mediated via the dioxin receptor, a ligand-dependent basic helix-loop-helix (bHLH)/PAS transcription factor. The latent dioxin receptor responds to dioxin signalling by forming an activated heterodimeric complex with a specific bHLH partner, Arnt, an essential process for target DNA recognition. We have analyzed the transactivating potential within this heterodimeric complex by dissecting it into individual subunits, replacing the dimerization and DNA-binding bHLH motifs with heterologous zinc finger DNA-binding domains. The uncoupled Arnt chimera, maintaining 84% of Arnt residues, forms a potent and constitutive transcription factor. Chimeric proteins show that the dioxin receptor also harbors a strong transactivation domain in the C terminus, although this activity was silenced by inclusion of 82 amino acids from the central ligand-binding portion of the dioxin receptor. This central repression region conferred binding of the molecular chaperone hsp90 upon otherwise constitutive chimeras in vitro, indicating that hsp90 has the ability to mediate a cis-repressive function on distant transactivation domains. Importantly, when the ligand-binding domain of the dioxin receptor remained intact, the ability of this hsp90-binding activity to confer repression became conditional rather than irreversible. Our data are consistent with a model in which crucial activities of the dioxin receptor, such as dimerization with Arnt and transactivation, are conditionally repressed by the central ligand- and-hsp90-binding region of the receptor. In contrast, the Arnt protein appears to be free from any repressive activity. Moreover, within the context of the dioxin response element (xenobiotic response element), the C terminus of Arnt conferred a potent, dominating transactivation function onto the native bHLH heterodimeric complex. Finally, the relative transactivation potencies of the individual dioxin receptor and Arnt chimeras varied with cell type and promoter architecture, indicating that the mechanisms for transcriptional activation may differ between these two subunits and that in the native complex the transactivation pathway may be dependent upon cell-specific and promoter contexts.
Integration of Visual and Text-Based Approaches for the Content Labeling and Classification of Photographs (1999)

Annotating photographs automatically with content descriptions facilitates organization, storage, and search over visual information. We present an integrated approach for scene classification that combines image-based and text-based approaches. On the text side, we use the text accompanying an image in a novel TF*IDF vector-based approach to classification. On the image side, we present a novel OF*IIF (object frequency) vector-based approach to classification. Objects are defined by clustering of segmented regions of training images. The image based OF*IIF approach is synergistic with the text based TF*IDF approach. By integrating the TF*IDF approach and the OF*IIF approach, we achieved a classification accuracy of 86%. This is an improvement of approximately 12% over existing image classifiers, an improvement of approximately 3% over the TF*IDF image classifier based on textual information, and an improvement of approximately 4% over the OF*IIF image classifier based on visual information.
Seat headrest development to detect the head position of passenger (2011)

It is the essential technique to percept the position of passenger’s head before rear collision to pre-crash headrest for minimizing the one’s neck damage. This research introduces the technique of perception of head using the electrostatic capacity sensor in the head rest. When the distance between the head rest and passenger’s head is measured, pre-crash headrest could be adjusted to most proper position for Whiplash protection. It will improve safety technology.