gebhart/patrepeval huggingface dataset:
Lactose malabsorption and intolerance: a review (2018)

Food lactose and lactose intolerance are today hot topics in the field of food and nutrition. About 70% of the adult world population is lactose-intolerant, due to low levels of intestinal lactase, also called lactase-phlorizin hydrolase (LPH), a β-d-galactosidase found in the apical surface of the intestinal microvilli. This may be due to the loss of intestinal lactase in adulthood, a condition transmitted by an autosomal recessive gene, which differs in humans according to race. According to the cultural-historical hypothesis, the mutation that allows the metabolization of lactose appeared about 10 000 years ago in the inhabitants of Northern Europe where mammalian milk continued in the diet after weaning, and lactase-persistent populations were genetically selected in some areas. Many intolerant individuals can tolerate low levels of lactose in their daily diet. Probiotics have also been proposed as an alternative that could avoid some symptoms of lactose intolerance. Many products are marketed nowadays as alternatives to dairy products for lactose-intolerant individuals. However, the rules for low-lactose foods are currently not harmonised in the European Union. As scientific knowledge on lactose intolerance has notably advanced in recent decades, the aim of this work was to review the current state of the knowledge on lactose and lactose intolerance, its diagnosis and clinical management, and the various food products that are offered specifically for non-tolerant individuals.
Activation of Multiple Effector Mechanisms to Enhance Tumor lmmunotherapy (1993)

Recent technical advances have enabled the generation of clinical reagents for immunotherapy. Currently, treatment protocols combining both interleukin-2 (IL-2) and tumor-specific monoclonal antibody are underway at the University of Wisconsin Comprehensive Cancer Center and elsewhere. These approaches are based on the hypothesis that IL-2-activated lymphocytes will use tumor-reactive antibody to more selectively and effectively destroy tumor in vivo. Just as IL-2 can activate lymphocytes to destroy antibody-coated tumor cells, other agents can activate neutrophils and monocytes to destroy antibody-treated tumor cells. We are investigating, in laboratory and clinic, approaches aimed at eventually using combinations of distinct antibody-based tumor recognition mechanisms in patients whose monocytes, neutrophils, and lymphocytes have been simultaneously activated with multiple biologic agents.
[Sociotherapy in the psychogeriatric nursing home. Possibilities for a psychogeriatric sociotherapy]. (1981)

Terms as sociotherapy, environment therapy and the therapeutical environment have their origin in psychiatry and from there influenced various other treatment settings. The basic philosophy however is still the same: people live and are treated in social organizations which have an influence on their feeling of well-being and chances on recovery. Depending on the specific characteristics, each treatment setting has developed different ways of interpreting and practicing this philosophy. One of the ways of defining the psychogeriatric interpretation of sociotherapy is the analysis of the behavior of the nurse in a psychogeriatric nursing-home, with a sociotherapeutic treatment philosophy, in relation to the patients. Evaluation of behavior in terms of its sociotherapeutic characteristics is not necessarily equivalent to sociotherapeutic behavior. It however gives a clearer view of the way a philosophy is practiced and the conditions under which this is done.
Glutamine nutrition and metabolism: Where do we go from here? (1996)

Glutamine, a "nonessential" amino acid, is attracting widespread attention because of its relevance to numerous metabolic processes and its potential role in the treatment and prevention of critical illness. In this paper we review some key concepts of glutamine biochemistry, metabolism, and nutrition. We then discuss several studies in the area of glutamine metabolism and nutrition that are primed for further investigation.
Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus. (1982)

Infection of HeLa cells with poliovirus results in a rapid shut-off of host protein synthesis. It has been suggested that inactivation of a protein that binds to the cap structure of cellular mRNAs would explain the selective inhibition of host protein synthesis because the naturally uncapped poliovirus RNA can be translated by a cap-independent mechanism. To test directly for the presence of cap-binding proteins in poliovirus-infected and mock-infected cells, we analyzed initiation factor preparations for their ability to specifically crosslink to the 5' cap structure of oxidized reovirus mRNA. The data presented here show that the crosslinking ability of the different cap-binding proteins (24-, 28-, 32-, 50-, and 80-kilodalton polypeptides) is reduced in preparations from poliovirus-infected as compared to mock-infected cells. This reduction correlates with the inability of initiation factor preparations from infected cells to restore translation of capped mRNAs in extracts of poliovirus-infected cells. In addition, initiation factor preparations from poliovirus-infected cells have the ability to rapidly inactivate cap-binding proteins and can also impair the restoring activity of initiation factors from mock-infected cells.
A practical trench isolation technology with a novel planarization process (1987)

We develop a new vertical-trench isolation method that utilizes a thin SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> film in-between double photoresists for uniform top-resist coating and for an etch-back barrier, a poly-silicon film above active regions for an etch-back buffer and large tilt-angle boron ion implantations into the trench-sidewalls for narrow channel effect control. The Planarization with the Resist / Oxide / Resist and the Poly _Silicon (PRORPS) can isolate the whole surface of a 6 inch-diameter wafer very uniformly with a large process margin. The standard deviation of the threshold voltage of a n-channel MOS-FET (W/L= 10µm/0.8µm) over the whole wafer is 0.38 % at about 0.6 V threshold voltage. The narrow-channel-effect is controlled for FET's down to 0.5 µm channel width. The method is applied to the megabit SCC (Surrounded Capacitor Cell) DRAM developed here and the cells and the peripheral-circuits are isolated at the same time successfully.
Quantifying Diffusion in a Biofilm of <i>Streptococcus mutans</i> (2010)

In biofilms, diffusion may limit the chemical activity of nutrients, toxic compounds, and medicines. This study provides direct, noninvasive insight into the factors that will most effectively limit the transport of antibiotics and biocides in biofilms. Self-diffusion coefficients have been determined for a number of fluorescent probes in biofilms of Streptococcus mutans using fluorescence correlation spectroscopy. The effects of probe size and charge and the roles of biofilm pH, ionic strength, and heterogeneity were studied systematically. The relative diffusion coefficients (D in the biofilm divided by that in water) decreased with increasing probe size (3,000-molecular-weight [3K], 10K, 40K, 70K, and 2,000K dextrans). Studies using variably charged substrates (tetramethylrhodamine, Oregon Green, rhodamine B, and rhodamine 6G) showed that the self-diffusion coefficients decreased with an increasing negative charge of the fluorescent probes. No significant effect was observed for changes to the ionic strength (10⁻⁴ to 10⁻¹ M) or pH (4 to 9) of the biofilm. Biofilm heterogeneity was responsible for variations of ca. one order of magnitude in the diffusion coefficients.
Reviewing of Your Proposal (2012)

This chapter contains sections titled: Introduction Who's Who in the Review Process Panel Meeting, Panel Summary, and Co-Review Review Decisions
A record of bar-breasted firefinch Lagonosticta rufopicta nitidula from Tanzania (1984)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Patterns of cell motility in the organizer and dorsal mesoderm of <i>Xenopus laevis</i> (1992)

In a companion paper (Shih, J. and Keller, R. (1992) Development 116, 901-914), we described a sequence of cell behaviors, called mediolateral intercalation behavior (MIB), that produces mediolateral cell intercalation, the process that drives convergence and extension of the axial and paraxial mesoderm of Xenopus. In this paper, we describe the pattern of expression of MIB in the mesoderm during gastrulation, using video image processing and recording of cell behavior in 'shaved', open-faced explants of the marginal zone. At midgastrula stage (10.5), MIB begins at two dorsolateral sites in the prospective anterior mesoderm and progresses medially along two arcs that lengthen toward and meet at the midline to form a single arc of cells expressing MIB, called the vegetal alignment zone (VgAZ). The notochordal-somitic mesodermal boundary forms within the VgAZ at stage 11, and then progresses animally and laterally, along the prospective anterior-posterior axis, eventually bounding a trapezoidal area the shape of the fate-mapped notochord. Meanwhile, from its origin in the VgAZ, MIB spreads in the prospective posterior direction along the lateral boundaries of both the notochordal and somitic mesoderm. From there it spreads medially in both tissues. Subsequently, vacuolation of notochord cells, and segmentation and expression of a somite-specific marker repeat the progression of mediolateral intercalation behavior. Thus cells in the posterior, medial regions of the notochordal and the somitic territories are the last to express mediolateral intercalation behavior and subsequent tissue differentiations. In explants that do not converge, these cells neither express mediolateral intercalation behavior nor differentiate. These facts suggest that progressions of MIB in the anterior-posterior and lateral-medial directions may be organized by signals emanating from the lateral somitic and notochordal boundaries. These signals may have limited range and may be dependent on convergence, driven by mediolateral cell intercalation, to bring cells within their range. In the embryo, the posterior progression of MIB results in arcs of convergence, anchored in the vegetal endoderm at each end, acting on the inside of the blastoporal lip to produce involution of the IMZ.
Impact absorption of four processed soft denture liners as influenced by accelerated aging. (1998)

The cushioning effect of soft denture liners was evaluated by using a free drop test with an accelerometer. Materials tested included SuperSoft (Coe Laboratories, Chicago, IL), Kurepeet-Dough (Kreha Chemical, Tokyo), Molteno Soft (Molten, Hiroshima, Japan), and Molloplast-B (Molloplast Regneri, Karlsruhe, Germany). All materials were found to reduce the impact force when compared to acrylic denture base resin. A 2.4-mm layer of soft denture material demonstrated good impact absorption, and Molloplast-B and Molteno had excellent impact absorption. When the soft denture liner was kept in an accelerated aging chamber for 900 hours, the damping effect recorded increased for all materials tested. Aging of all materials also affected the cushioning effect.
Personalized active learning for collaborative filtering (2008)

Collaborative Filtering (CF) requires user-rated training examples for statistical inference about the preferences of new users. Active learning strategies identify the most informative set of training examples through minimum interactions with the users. Current active learning approaches in CF make an implicit and unrealistic assumption that a user can provide rating for any queried item. This paper introduces a new approach to the problem which does not make such an assumption. We personalize active learning for the user, and query for only those items which the user can provide rating for. We propose an extended form of Bayesian active learning and use the Aspect Model for CF to illustrate and examine the idea. A comparative evaluation of the new method and a well-established baseline method on benchmark datasets shows statistically significant improvements with our method over the performance of the baseline method that is representative for existing approaches which do not take personalization into account.
Person tracking in three-dimensional laser range data with explicit occlusion adaption (2011)

This paper presents an approach to exploit the richer information of sensor data provided by 3d laser rangefinders for the purpose of person tracking. Introduced is a method to adapt the observation model of a particle filter, to identify partial and full occlusions of a person, to determine the amount of occlusion behind an obstacle, and the occluding obstacle itself. This is done by tracing rays from positions near the person to the sensor and determining whether the ray hits an obstacle. The laser range data is represented using a voxel grid, which facilitates efficient retrieval and data reduction. As our experiments show, our proposed tracking approach is able to reliably keep track of a person in real-time, even when only partially visible, when moving in uneven terrain, or when the person passes closely another person of different size.
Nuclear/Nucleolar morphometry and DNA image cytometry as a combined diagnostic tool in pathology of prostatic carcinoma. (2001)

Paraffin tissue sections from 50 patients with prostate adenocarcinoma were used to study nuclear and nucleolar morphometric features by image analysis. The results were compared to DNA ploidy and Gleason grade. In the examined histological samples nuclear and nucleolar areas were positively interrelated. It was also noticed that the higher the percentage of nucleolated nuclei, the bigger the nuclear and nucleolar areas. The morphometric characteristics did not differ significantly among the four grades of the examined specimens. In well-differentiated carcinomas the DNA index was lower than in the rest at a statistically significant level. Hypodiploid carcinomas were found to possess significantly bigger nuclear areas than any other DNA index group. Morphonuclear evidence of anaplasia and DNA aneuploidy may be used as diagnostic tools in prostate cancer in addition to Gleason grade.
Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome (2020)

Coronavirus disease 2019 (COVID-19) is a rapidly expanding global pandemic caused by severe acute respiratory syndrome coronavirus 2, resulting in significant morbidity and mortality. A substantial minority of patients hospitalized develop an acute COVID-19 cardiovascular syndrome, which can manifest with a variety of clinical presentations but often presents as an acute cardiac injury with cardiomyopathy, ventricular arrhythmias, and hemodynamic instability in the absence of obstructive coronary artery disease. The cause of this injury is uncertain but is suspected to be related to myocarditis, microvascular injury, systemic cytokine-mediated injury, or stress-related cardiomyopathy. Although histologically unproven, severe acute respiratory syndrome coronavirus 2 has the potential to directly replicate within cardiomyocytes and pericytes, leading to viral myocarditis. Systemically elevated cytokines are also known to be cardiotoxic and have the potential to result in profound myocardial injury. Prior experience with severe acute respiratory syndrome coronavirus 1 has helped expedite the evaluation of several promising therapies, including antiviral agents, interleukin-6 inhibitors, and convalescent serum. Management of acute COVID-19 cardiovascular syndrome should involve a multidisciplinary team including intensive care specialists, infectious disease specialists, and cardiologists. Priorities for managing acute COVID-19 cardiovascular syndrome include balancing the goals of minimizing healthcare staff exposure for testing that will not change clinical management with early recognition of the syndrome at a time point at which intervention may be most effective. This article aims to review the best available data on acute COVID-19 cardiovascular syndrome epidemiology, pathogenesis, diagnosis, and treatment. From these data, we propose a surveillance, diagnostic, and management strategy that balances potential patient risks and healthcare staff exposure with improvement in meaningful clinical outcomes.
Control of PbSe Quantum Dot Surface Chemistry and Photophysics Using an Alkylselenide Ligand (2012)

We have synthesized alkylselenide reagents to replace the native oleate ligand on PbSe quantum dots (QDs) in order to investigate the effect of surface modification on their stoichiometry, photophysics, and air stability. The alkylselenide reagent removes all of the oleate on the QD surface and results in Se addition; however, complete Se enrichment does not occur, achieving a 53% decrease in the amount of excess Pb for 2 nm diameter QDs and a 23% decrease for 10 nm QDs. Our analysis suggests that the Se ligand preferentially binds to the {111} faces, which are more prevalent in smaller QDs. We find that attachment of the alkylselenide ligand to the QD surface enhances oxidative resistance, likely resulting from a more stable bond between surface Pb atoms and the alkylselenide ligand compared to Pb-oleate. However, binding of the alkylselenide ligand produces a separate nonradiative relaxation route that partially quenches PL, suggesting the formation of a dark hole-trap.
Identification of a plasmid-borne parathion hydrolase gene from Flavobacterium sp. by southern hybridization with opd from Pseudomonas diminuta (1986)

Parathion hydrolases have been previously described for an American isolate of Pseudomonas diminuta and a Philippine isolate of Flavobacterium sp. (ATCC 27551). The gene which encodes the broad-spectrum organophosphate phosphotriesterase in P. diminuta has been shown by other investigators to be located on a 66-kilobase (kb) plasmid. The intact gene (opd, organophosphate-degrading gene) from this degradative plasmid was cloned into M13mp10 and found to express parathion hydrolase under control of the lac promoter in Escherichia coli. In Flavobacterium sp. strain ATCC 27551, a 43-kb plasmid was associated with the production of parathion hydrolase by curing experiments. The M13mp10-cloned fragment of the opd gene from P. diminuta was used to identify a homologous genetic region from Flavobacterium sp. strain ATCC 27551. Southern hybridization experiments demonstrated that a genetic region from the 43-kb Flavobacterium sp. plasmid possessed significant homology to the opd sequence. Similar hybridization did not occur with three other native Flavobacterium sp. plasmids (approximately 23, 27, and 51 kb) present within this strain or with genomic DNA from cured strains. Restriction mapping of various recombinant DNA molecules containing subcloned fragments of both opd plasmids revealed that the restriction maps of the two opd regions were similar, if not identical, for all restriction endonucleases tested thus far. In contrast, the restriction maps of the cloned plasmid sequences outside the opd regions were not similar. Thus, it appears that the two discrete bacterial plasmids from parathion-hydrolyzing soil bacteria possess a common but limited region of sequence homology within potentially nonhomologous plasmid structures.
Development of Autonomous Emergency Braking control system based on road friction (2014)

Autonomous emergency brake (AEB) is one of important vehicle active safety function to avoid or mitigate collision. In general, the AEB system employs a Time-To-Collision (TTC) to measure the potential danger of impact into obstacles. Once the TTC is smaller than desired threshold, the AEB would activate the braking system. The threshold of TTC for braking is designed based on assuming road friction to be a constant. However, the actual road condition is intricate and changed at any time. Therefore, an AEB strategy considering the effect of different road friction on the braking threshold of TTC is developed. First, a combined-slip tire model is used to estimate peak road friction. The estimated peak road friction is then used to obtain braking threshold of TTC. Since the road friction can be identified in real-time, the proposed AEB algorithm can adapt to different road surface. The simulation results show that proposed control strategy has batter performance than that of the conventional one.
On a ferroelastic mechanism governing the toughness of metastable tetragonal-prime ( <i>t</i> ′) yttria-stabilized zirconia (2007)

This article investigates the toughness of yttria-stabilized zirconia (YSZ) with the tetragonal-prime ( t ′) structure. Such materials are used as durable thermal barriers in gas turbines. Their durability has been attributed to high toughness, relative to materials in the cubic phase field. Based on prior literature, a ferroelastic toughening mechanism is hypothesized and this assertion is examined by characterizing the material in the wake of an indentation-induced crack. Assessment by transmission electron microscopy, Raman spectroscopy and optical interferometry has affirmed the existence of a process zone, approximately 3 μm in width, containing a high density of nano-scale domains, with equal proportions of all three crystallographic variants. Outside the zone, individual grains contain a single variant (no domains) implying that the toughening mechanism is controlled by domain nucleation (rather than the motion of pre-existing twin boundaries). The viability of the ferroelastic toughening mechanism is assessed using a process zone model that relates the observed toughening to the stress/strain hysteresis accompanying domain formation. Based on the measured process zone size, the known tetragonality of t ′-7 wt% YSZ and the enhancement in toughness relative to cubic YSZ, consistency between the model and the observed toughening is demonstrated for a reasonable choice of the coercive stress.
Natural gas supply; More efficient recovery at less cost (1989)

This article reports on gas supply developments from GRI. These developments represent technology that is now being used in the field or will be available for use soon. Among GRI's natural gas supply R and D activities is its staged field experiment (SFE) project being conducted through the tight gas sands program. An SFE is a well drilled specifically to conduct experiments and gather research data that will lead to increased production and improved recovery of gas from tight gas sand reservoirs. These field-based experiments provide a controlled environment and allow flexibility for conducting experiments that extend beyond typical well drilling and completion operations.
Notizen: Zur Kenntnis eines Quecksilberwasserstoffs HgH<sub>2</sub> (1951)

Lithiumalanat und Quecksilberjodid setzen sich in Äther-Tetra-hydrofuran-Petroläther-Lösung bei -135° unter Bildung eines festen, weißen Quecksilberwasserstoffs, HgH 2 , um, der bis -125° beständig ist und oberhalb dieser Temperatur in die Elemente zerfällt.
Cryogenic system for a large superconducting magnet in space (2003)

The Alpha Magnetic Spectrometer (AMS) is a particle physics experiment for use on the International Space Station (ISS). At the heart of the detector will be a large superconducting magnet cooled to a temperature of 1.8 K by 2500 liters of superfluid helium. The magnet and cryogenic system are currently under construction by Space Cryomagnetics Ltd of Culham, England. This paper describes the cryogenic system for the magnet, designed for the unusual challenges of operating a superconducting system in space. Results from experiments demonstrating some of the new techniques and devices developed for the magnet cryogenics are also presented.