gebhart/patrepeval huggingface dataset:
Modern VLSI Design: IP-Based Design (2008)

The Number 1 VLSI Design GuideNow Fully Updated for IP-Based Design and the Newest TechnologiesModern VLSI Design, Fourth Edition, offers authoritative, up-to-the-minute guidance for the entire VLSI design processfrom architecture and logic design through layout and packaging. Wayne Wolf has systematically updated his award-winning book for todays newest technologies and highest-value design techniques. Wolf introduces powerful new IP-based design techniques at all three levels: gates, subsystems, and architecture. He presents deeper coverage of logic design fundamentals, clocking and timing, and much more. No other VLSI guide presents as much up-to-date information for maximizing performance, minimizing power utilization, and achieving rapid design turnarounds. Coverage includesAll-new material on IP-based designExtensive new coverage of networks-on-chipsNew coverage of using FPGA fabrics to improve design flexibilityNew material on image sensors, busses, Rents Rule, pipelining, and moreUpdated VLSI technology parameters reflecting the latest advancesRevised descriptions of HDLs and other VLSI design toolsAdvanced techniques for overcoming bottlenecks and reducing crosstalkLow-power design techniques for enhancing reliability and extending battery lifeTesting solutions for every level of abstraction, from gates to architectureRevamped end-of-chapter problems that fully reflect todays VLSI design challengesWolf introduces a top-down, systematic design methodology that begins with high-level models, extends from circuits to architecture, and facilitates effective testing. Along the way, he brings together all the skills VLSI design professionals will need to create tomorrows state-of-the-art devices.
Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates (2005)

These results indicate that there are multiple alleles and genotypes associated with T1DM and that the risk associated with different genetic markers depends on the age of disease onset, suggesting that some markers may be involved in more rapid disease progression.
Kinetic data for the crosslinking reaction of polycarboxylic acids with cellulose (1997)

Kinetic data (rate constant, Arrhenius activation energy, frequency factor) of the esterification of polycarboxylic acids (butane‐1, 2, 3, 4‐tetracarboxylic acid, citric acid and pyromellitic acid) have been determined by means of isocratic HPLC measuring the portion of polycarboxylic acid that does not react with cellulosic material. The order of activation energy is as follows: citric acid > butane‐1, 2, 3, 4‐tetracarboxylic acid > pyromellitic acid.
Digital Inheritance of Personal and Commercial Content Using DRM (2007)

Due to current new trends in the field of digital technologies, people nowadays own and need to manage increasing amounts of digital data including commercial and personal content. As with other assets, an important aspect in dealing with digital content is how to regulate inheritance of this digital property. The problem becomes even harder in case the content is protected by or used in a DRM system. In this paper, we address this problem by describing a method that supports creation and enforcement of a digital will (testament).
Control of Amorphization of IrO2-Ta2O5/Ti Electrodes to Suppress Unwanted Side Reactions (2009)

Titanium electrodes coated with mixtures of IrO2 and Ta2O5 were prepared using different compositions of precursor solutions and at different thermal decomposition temperatures. The mixed oxide coatings became amorphous when the Ir content and/or thermal decomposition temperature decreased. The amorphization of the coating was effective to suppress anodic PbO2 deposition because of the increase in nucleation overpotential of PbO2 on the amorphous coating.
Epigenetic inactivation of the canonical wnt antagonist secreted frizzled-related protein 1 in hepatocellular carcinoma cells (2012)

Secreted Frizzled-related protein 1 (sFRP1), as one of most important Wnt antagonists, is frequently silenced by promoter hypermethylation in many types of tumor, including hepatocellular carcinoma (HCC). In this study, we aimed to investigate whether restoration of sFRP1 affected HCC metastatic behavior. sFRP1 mRNA expression and promoter methylation in HCC tissues and cell lines were examined using RT-PCR and methylation-specific PCR (MS-PCR), respectively. sFRP1 protein expression was assessed by Western Blot. We generated stable HCC cell line restoration of sFRP1 in HepG2 cells, which naturally do not express detectable sFRP1 mRNA. The effects of exogenous sFRP1 on HepG2 cell invasion were investigated using trans-well assay. Also the effects of sFRP1 re-expression on the β-catenin/T-cell factor-dependent transcription activity was measured by luciferase assay.sFRP1 promoter methylation was frequently observed in HCC tissues (60%) and cell lines (75%). All samples with sFRP1 methylation showed down-regulation of sFRP1 expression in HCC cell lines. Demethylation treatment with 5-aza-20-deoxycytidine in HCC cells restored sFRP1 expression. Restoration of sFRP1 substantially impaired the invasive potentials of HepG2 cells. Moreover, exogenous sFRP1 caused significant decrease of β-catenin/T-cell factor-dependent transcription activity.These findings demonstrate that sFRP1 silencing due to promoter hypermethylation is a major event during tumorigenesis. sFRP1 is also a negative modulator of canonical Wnt signaling, which could contribute to metastasis in HCC progression, thus providing a possible therapeutic strategy against HCC.
Hermann v. Helmholtz † (1894)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Novel Solid-Phase Reagents for Facile Formation of Intramolecular Disulfide Bridges in Peptides under Mild Conditions<sup>1</sup><sup>,</sup><sup>2</sup> (1998)

The controlled formation of intramolecular disulfide bridges in peptides, while avoiding unwanted oligomerization, is a significant challenge. Ellman's reagent, 5,5‘-dithiobis(2-nitrobenzoic acid), was developed originally in the context of an assay for measuring free thiol concentration under physiological conditions. The present studies demonstrate that this reagent, when bound through two sites to a suitable solid support (PEG-PS, modified Sephadex, or controlled-pore glass), is an effective mild oxidizing reagent that promotes the formation of disulfide bridges. Rates and yields of the reactions were determined as a function of pH, excess of oxidizing reagent, resin loading, and parent support, for the preparation of oxytocin and deamino-oxytocin (9 residues, disulfide bridge between residues 1 and 6), somatostatin (14 residues, disulfide bridge between residues 3 and 14), α-conotoxin SI (13 residues, disulfide bridges between residues 2 and 7; 3 and 13), and apamin (18 residues, disulfide bridges between residues 1 and 11; 3 and 15). Cystine dimers of these peptide models formed, if at all, in relatively low amounts. Use of solid-phase Ellman's reagents to oxidize the linear precursors of conotoxin or apamin (tetrathiols) gave as the main products the correctly paired regioisomers. Particular advantages of the overall approach include fast reaction rates over a wide range of pH, from 2.7 to 6.6; easy purification of disulfide-containing products; and the specificity and reusability of the reagents.
LOW TEMPERATURE SPECTROSCOPY OF GLYOXAL (1975)

Author Institution: Department of Chemistry, Brandeis University
First Evidence That Oligopyridines, α-Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-x<sub>L</sub>-Targeting Strategies (2015)

Apoptosis control defects such as the deregulation of Bcl-2 family member expression are frequently involved in chemoresistance. In ovarian carcinoma, we previously demonstrated that Bcl-xL and Mcl-1 cooperate to protect cancer cells against apoptosis and their concomitant inhibition leads to massive apoptosis even in the absence of chemotherapy. Whereas Bcl-xL inhibitors are now available, Mcl-1 inhibition, required to sensitize cells to Bcl-xL-targeting strategies, remains problematic. In this context, we designed and synthesized oligopyridines potentially targeting the Mcl-1 hydrophobic pocket, evaluated their capacity to inhibit Mcl-1 in live cells, and implemented a functional screening assay to evaluate their ability to sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. We established structure-activity relationships and focused our attention on MR29072, named Pyridoclax. Surface plasmon resonance assay demonstrated that pyridoclax directly binds to Mcl-1. Without cytotoxic activity when administered as a single agent, pyridoclax induced apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells.
Ultrasonic Evaluation of Artificial Kissing Bonds in CFRP Composites (2014)

The primary aim of this paper is to create artificial inter-laminar kissing bond-like defects in CFRP panels for ultrasonic inspection. Carbon fibre reinforced polymer structures pose a unique problem, as unlike metal-tometal bonds (single bond line) carbon fibre reinforced polymer composites have multiple bond lines (between each laminate layer and between the individual carbon fibre bundles). This increases the number of locations for kissing bonds and other defects to lie. Published works look at bonding defects in joints (lap joints, and solidsolid bonding). This paper looks at inter-laminar bonding. A number of samples are created and attempts are then made to detect these kissing bonds using ultrasonic techniques. Further investigation into contaminants for artificial defect creation is advised and destructive verification of the kissing bond samples is still required.
A high power density three-phase PFC converter based on VIENNA topology (2012)

This paper presents a front end grid connected power converter which is based on a non-regenerative three-level bidirectional-switch VIENNA rectifier. The whole system is controlled by a digital method. The controller is implemented in carrier based PWM strategy. The control method and the simulation are presented. An experimental prototype is built to verify the theoretical analysis and the simulation. The experimental results are given. The switching frequency of the converter is 100 kHz; the efficiency reaches 96.5% at the rated condition. During the wide input range, the THDi value is controlled to be less than 5%.
The FMC Mass Preservation System (1991)

FMC Corporation has developed a mass preservation chemical treatment process that not only neutralizes the acid in paper to extend the document's useful life but also strengthens the damaged pages, kto enhance the usability of the document. Documents treated by the FMC process are virtually indistinguishable from untreated ones. To determine the quality of treatment, and compare the ability of alternative mass preservation technologies to enhance and extend the useful life of documents, FMC published a proposed evaluation strategy klinn February 1990. This article summarizes the evaluation strategy, describes the FMC process and communicates the results of independent laboratory testing conducted on FMC's mass preservation process
Combination of linear and circular SAR for 3-D features (2002)

An economic and fast change of an existing radar system with a linear synthetic aperture into a system with 3D capabilities is presented. For actual and future fields of radar in remote sensing, such as high precision mine detection, highly accurate vegetation measurements and interferometric SAR applications the importance of resolution in the third dimension is growing fast. Until now a such a radar required an expensive phased array antenna, a costly narrow-beam scanning system, or a combination of both of them. In order to overcome these problems, the combination of an existing linear SAR outdoor system (LISA) with a circular aperture for vertical resolution led to a fast and economic additional 3rd dimension feature. A test experiment has been performed to validate the system and the implemented SAR processor. The very promising results are presented.
Reduction of cyclic anhydrides with sodium borohydride. Versatile lactone synthesis (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReduction of cyclic anhydrides with sodium borohydride. Versatile lactone synthesisDenis M. Bailey and Robert E. JohnsonCite this: J. Org. Chem. 1970, 35, 10, 3574–3576Publication Date (Print):October 1, 1970Publication History Published online1 May 2002Published inissue 1 October 1970https://pubs.acs.org/doi/10.1021/jo00835a091https://doi.org/10.1021/jo00835a091research-articleACS PublicationsRequest reuse permissionsArticle Views3060Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Reactions of 3‐Hydrazino‐5,6‐diphenyl‐1,2,4‐triazine with α,β‐Bifunctional Compounds. (1987)

Abstract The title compound reacts with various α,β‐bifunctional compounds to give rise to formation of heterobicyclic systems in good to excellent yields.
Tumor promoter phorbol myristic acetate stimulates immunoglobulin secretion correlated with growth cessation in human B lymphocyte cell lines. (1981)

Immunoglobulin production by lymphoblast cell lines was studies using protein A-red blood cell plaque formation to detect individual secreting cells. Immunoglobulin (Ig) secretion by 6 of 12 human B-cell lines tested could be stimulated up to twentyfold by phorbol myristic acetate (PMA) at subtoxic concentrations of 10-1000 ng/ml depending on the line. Stimulation was found with both IgM and IgG cell lines. No switch of Ig class synthesis was found in the cell lines as a result of PMA incubation. Increase in Ig secretion was closely associated with cessation of growth resembling induction of terminal differentiation in the cells. PMA induction of Ig secretion in B lymphocytes from normal peripheral blood requires the cooperation of T cells. PMA stimulation of certain cell lines reported here suggests that the lines are late in the differentiation pathway to plasmacyte and can be easily triggered to secrete Ig by membrane-altering agents.
Oral Administration of Paramylon, a .BETA.-1,3-D-Glucan Isolated from Euglena gracilis Z Inhibits Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice (2010)

Paramylon is a beta-1,3-D-glucan isolated from Euglena gracilis Z. This study was designed to evaluate the suppressive effects of the oral administration of paramylon on the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of 2,4,6-trinitrochlorobenzene (TNCB) in sensitized NC/Nga mice. The effects of paramylon were assessed by measuring macroscopical and histopathological findings of skin, ear swelling, serum levels of total IgE, interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) and IL-18 and IL-12 contents in the skin lesions. Oral administration of paramylon inhibited the development of AD-like skin lesions as exemplified by a significant decrease in dermatitis scores for the back, ear swelling and hypertrophy of the skin, infiltration of inflammatory cells in the skin, and serum IgE levels. Oral administration of paramylon reduced serum levels of both IL-4 and IFN-gamma and IL-18 and IL-12 contents in the skin lesions. Oral administration of paramylon did not cause weight loss, as was observed with prednisolone. These results suggest that paramylon inhibits the development of AD-like skin lesions in NC/Nga mice by suppressing both the T-helper (Th) 1 and Th 2 cell responses. Our results indicate that paramylon treatment could provide an effective alternative therapy for the management of AD.
An investigation and a proposal for handover decision-making in DVB-H (2005)

Digital Video Broadcasting for Handhelds (DVB-H) is a standard for broadcasting TV like IP data content to portable devices, such as mobile phones, personal digital assistants (PDAs), laptops, etc. Handover in unidirectional broadcasting networks is a novel issue. Since making accurate handover decisions can reduce the battery power consumed, this paper proposes and investigates different strategies that can assist the handover decision-making process in DVB-H networks. The benefits and drawbacks of the different algorithms are presented. A hybrid handover decision-making algorithm is proposed. Future research directions for handover in DVB-H are suggested.
Interconversion of the Specificities of Human Lysosomal Enzymes Associated with Fabry and Schindler Diseases (2010)

The human lysosomal enzymes alpha-galactosidase (alpha-GAL, EC 3.2.1.22) and alpha-N-acetylgalactosaminidase (alpha-NAGAL, EC 3.2.1.49) share 46% amino acid sequence identity and have similar folds. The active sites of the two enzymes share 11 of 13 amino acids, differing only where they interact with the 2-position of the substrates. Using a rational protein engineering approach, we interconverted the enzymatic specificity of alpha- GAL and alpha-NAGAL. The engineered alpha-GAL (which we call alpha-GAL(SA)) retains the antigenicity of alpha-GAL but has acquired the enzymatic specificity of alpha-NAGAL. Conversely, the engineered alpha-NAGAL (which we call alpha-NAGAL(EL)) retains the antigenicity of alpha-NAGAL but has acquired the enzymatic specificity of the alpha-GAL enzyme. Comparison of the crystal structures of the designed enzyme alpha-GAL(SA) to the wild-type enzymes shows that active sites of alpha-GAL(SA) and alpha-NAGAL superimpose well, indicating success of the rational design. The designed enzymes might be useful as non-immunogenic alternatives in enzyme replacement therapy for treatment of lysosomal storage disorders such as Fabry disease.
The effect of tunicamycin on wall-polymer synthesis in Bacilli (1980)

Conference Article| April 01 1980 The effect of tunicamycin on wall-polymer synthesis in Bacilli J. BARRIE WARD; J. BARRIE WARD 1Division of Microbiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K. Search for other works by this author on: This Site PubMed Google Scholar ANNE W. WYKE; ANNE W. WYKE 1Division of Microbiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K. Search for other works by this author on: This Site PubMed Google Scholar CAROL A. M. CURTIS CAROL A. M. CURTIS 1Division of Microbiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1980) 8 (2): 164–166. https://doi.org/10.1042/bst0080164 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation J. BARRIE WARD, ANNE W. WYKE, CAROL A. M. CURTIS; The effect of tunicamycin on wall-polymer synthesis in Bacilli. Biochem Soc Trans 1 April 1980; 8 (2): 164–166. doi: https://doi.org/10.1042/bst0080164 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: MurAc, acetylmuramoyl, GlcNAc, N-acetylglucosamine, GalNAc, N-acetylgalactosamine This content is only available as a PDF. © 1980 Biochemical Society1980 Article PDF first page preview Close Modal You do not currently have access to this content.
Segment Routing Point-to-Multipoint Policy (2019)

This document describes an architecture to construct a Point-to-
Multipoint (P2MP) tree to deliver Multi-point services in a Segment
Routing domain. A SR P2MP tree is constructed by stitching a set of
Replication segments together. A SR Point-to-Multipoint (SR P2MP)
Policy is used to define and instantiate a P2MP tree which is computed
by a PCE.
WSCAD: a collaborative CAD system based on Web service (2005)

The rapid development of communication and computer network technology provides a solid ground for computer supported collaborative design. This work presents a distributed collaborative CAD system based on Web service. The system employs feature as its collaborative design element and uses XML to define feature operations and communication protocol between the server and the client. The system updates the feature information on the client incrementally in order to reduce network load and increase response ability. As it is constructed with Web service, the system supports collaboratively designing on heterogeneous platforms. The framework and communication protocols of it are analyzed in detail. The experimental results from the developed prototype system show that, the system is able to effectively support collaborative design under the distributed environment.
Improvement in Progression-Free Survival in OCEANS Bevacizumab Arm: A Critical Point of View (2012)

The authors analyze the critical points and the results of the paper OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer,published by Aghajanian C et al on 10 june 2012 in J Clin Oncol
Inhibition of Glutamine Synthetase Triggers Apoptosis in Asparaginase-Resistant Cells (2005)

The resistance to L-asparaginase (ASNase) has been associated to the overexpression of asparagine synthetase (AS), although the role played by other metabolic adaptations has not been yet defined. Both in ASNase-sensitive Jensen rat sarcoma cells and in ARJ cells, their ASNase-resistant counterparts endowed with a five-fold increased AS activity, ASNase treatment rapidly depletes intracellular asparagine. Under these conditions, cell glutamine is also severely reduced and the activity of glutamine synthetase (GS) is very low. After 24 h of treatment, while sensitive cells have undergone massive apoptosis, ARJ cells exhibit a marked increase in GS activity, associated with overexpression of GS protein but not of GS mRNA, and a partial restoration of glutamine and asparagine. However, when ARJ cells are treated with both ASNase and L-methionine-sulfoximine (MSO), an inhibitor of GS, no restoration of cell amino acids occurs and the cell population undergoes a typical apoptosis. No toxicity is observed upon MSO treatment in the absence of ASNase. The effects of MSO are not referable to depletion of cell glutathione or inhibition of AS. These findings indicate that, in the presence of ASNase, the inhibition of GS triggers apoptosis. GS may thus constitute a target for the suppression of ASNase-resistant phenotypes.