gebhart/patrepeval huggingface dataset:
Privacy-Preserving Multi-Keyword Ranked Search over Encrypted Cloud Data (2013)

With the advent of cloud computing, data owners are motivated to outsource their complex data management systems from local sites to the commercial public cloud for great flexibility and economic savings. But for protecting data privacy, sensitive data have to be encrypted before outsourcing, which obsoletes traditional data utilization based on plaintext keyword search. Thus, enabling an encrypted cloud data search service is of paramount importance. Considering the large number of data users and documents in the cloud, it is necessary to allow multiple keywords in the search request and return documents in the order of their relevance to these keywords. Related works on searchable encryption focus on single keyword search or Boolean keyword search, and rarely sort the search results. In this paper, for the first time, we define and solve the challenging problem of privacy-preserving multi-keyword ranked search over encrypted data in cloud computing (MRSE). We establish a set of strict privacy requirements for such a secure cloud data utilization system. Among various multi-keyword semantics, we choose the efficient similarity measure of "coordinate matching," i.e., as many matches as possible, to capture the relevance of data documents to the search query. We further use "inner product similarity" to quantitatively evaluate such similarity measure. We first propose a basic idea for the MRSE based on secure inner product computation, and then give two significantly improved MRSE schemes to achieve various stringent privacy requirements in two different threat models. To improve search experience of the data search service, we further extend these two schemes to support more search semantics. Thorough analysis investigating privacy and efficiency guarantees of proposed schemes is given. Experiments on the real-world data set further show proposed schemes indeed introduce low overhead on computation and communication.
Low-Grade Waste Heat Recovery for Power Production using an Absorption-Rankine Cycle (2010)

An investigation of heat recovery for power generation using an absorption-Rankine cycle with a low temperature waste heat source was conducted. In such a cycle, the condenser and boiler of a conventional Rankine system are replaced with an absorber and desorber. A recuperative solution heat exchanger is also incorporated between the absorber and desorber to minimize the external heat input. An ionic liquid-refrigerant pair is used as the working fluid, for which fluid properties were developed using the Peng-Robinson equation of state for a binary mixture. A detailed thermodynamic model of the system was developed to understand the potential of this cycle and working fluid combination. It was shown that the system is capable of achieving 15 percent conversion efficiencies using waste heat in the 130-160°C range. A parametric study also shows that the system can operate over a range of source and sink temperatures. The effects of solution heat exchanger efficiency and turbine efficiency on system performance are also investigated.
TRC120038, a Novel Dual AT<sub><b>1</b></sub>/ET<sub><b>A</b></sub>Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats (2011)

In hypertensive subjects, angiotensin II and endothelin participate in a manner involving closely interwoven pathways in increasing blood pressure (BP) and inducing end organ damage. The primary objective of this study was to determine the effect of TRC120038, a novel dual AT(1)/ET(A) receptor blocker on BP, in obese Zucker spontaneously hypertensive fatty rats (ob-ZSF1), an animal model of moderate hypertension, diabetes with progressive renal and cardiac dysfunction. Ob-ZSF1 rats loaded with 0.5% salt were treated with TRC120038 (11.8 mg/kg bid.) or candesartan cilexetil (0.3 mg/kg od.) or vehicle control. Blood pressure (by radio-telemetry) and renal functional markers were monitored throughout the study. Cardiac function was assessed terminally by pressure volume catheter. Markers for renal dysfunction were measured and changes were evaluated histopathologically. TRC120038 showed greater fall in both systolic and diastolic BP in comparison to candesartan at its maximum antihypertensive dose. TRC120038 also reduced the severity of renal dysfunction and preserved cardiac function in ob-ZSF1 rat.
Correlation between Phylogroups and Intracellular Proteomes of<i>Propionibacterium acnes</i>and Differences in the Protein Expression Profiles between Anaerobically and Aerobically Grown Cells (2013)

Propionibacterium acnes is one of the dominant commensals on the human skin and also an opportunistic pathogen in relation to acne, sarcoidosis, prostate cancer, and various infections. Recent investigations using housekeeping and virulence genes have revealed that the species consists of three major evolutionary clades (types I, II, and III). In order to investigate protein expression differences between these phylogroups, proteomic profiles of 21 strains of P. acnes were investigated. The proteins extracted from cells cultured under anaerobic and aerobic conditions were analysed using a SELDI-TOF mass spectrometer, high-resolution capillary gel electrophoresis, and LC-MS/ MS. The SELDI spectral profiles were visualised as a heat map and a dendrogram, which resulted in four proteomic groups. Strains belonging to type I were represented in the proteome Group A, while Group B contained type III strains. Groups C and D contained mixtures of types I and II. Each of these groups was not influenced by differences in culture conditions. Under anoxic growth conditions, a type IB strain yielded high expressions of some proteins, such as methylmalonyl-CoA epimerase and the Christie-Atkins-Munch-Petersen (CAMP) factor. The present study revealed good congruence between genomic and proteomic data suggesting that the microenvironment of each subtype may influence protein expression.
Antizyme Restrains Centrosome Amplification by Regulating the Accumulation of Mps1 at Centrosomes (2010)

Extra centrosomes are found in many tumors, and their appearance is an early event that can generate aberrant mitotic spindles and aneuploidy. Because the failure to appropriately degrade the Mps1 protein kinase correlates with centrosome overproduction in tumor-derived cells, defects in the factors that promote Mps1 degradation may contribute to extra centrosomes in tumors. However, while we have recently characterized an Mps1 degradation signal, the factors that regulate Mps1 centrosomal Mps1 are unknown. Antizyme (OAZ), a mediator of ubiquitin-independent degradation and a suspected tumor suppressor, was recently shown to localize to centrosomes and modulate centrosome overproduction, but the known OAZ substrates were not responsible for its effect on centrosomes. We have found that OAZ exerts its effect on centrosomes via Mps1. OAZ promotes the removal of Mps1 from centrosomes, and centrosome overproduction caused by reducing OAZ activity requires Mps1. OAZ binds to Mps1 via the Mps1 degradation signal and modulates the function of Mps1 in centrosome overproduction. Moreover, OAZ regulates the canonical centrosome duplication cycle, and reveals a function for Mps1 in procentriole assembly. Together, our data suggest that OAZ restrains the assembly of centrioles by controlling the levels of centrosomal Mps1 through the Cdk2-regulated Mps1 degradation signal.
Generalized Integrating-Sphere Theory (1967)

A general equation is developed for the efficiency of an integrating sphere with a nonuniform coating. The only assumptions are that the interior is a perfect sphere and that all areas reflect perfectly diffusely. Three special cases of the general equation are examined for the basic applications of integrating spheres as mixing mechanisms in hemispherical reflectance measurements and in absolute reflectance techniques.
Complement and Biocompatibility (1998)

Blood contact with foreign surfaces induces a certain degree of activation of the defence systems including complement. Recent data using complement specific inhibitors have shown that complement is not only associated with, but in fact contributes to the whole body inflammatory reaction seen as a complication of cardiopulmonary bypass (artificial surfaces) and is responsible for the hyperacute rejection of xenografts (foreign endothelium). Complement activation products, particularly the terminal SC5b-9 complex (TCC), is a sensitive indicator of bioincompatibility. Modifications of the artificial surfaces by coating with heparin improves both coagulation and complement compatibility. The use of specific complement inhibitors in general improves biocompatibility both of artificial materials and foreign endothelium.
A pitch synchronous scheme for very low bit rate speech coding (1992)

Fixed length speech frames are analysed to generate LPC coefficients describing the short term spectrum. Voiced frames are examined to determine sets of excitation points corresponding to instants of glottal closure. A voiced excitation signal is constructed in the form of a prototype pulse train, each pulse positioned at an excitation point. The amplitudes of the pulses are assumed to vary linearly across a voiced speech frame and an optimal linear regression line describing the variation is found for each frame. A new and reliable excitation point finder algorithm is based on a model of a glottal cycle as consisting of closed, opening and closing phases. The vocal tract resonances are excited mainly at glottal closure with less significant secondary excitation at opening. The excitation signal is convolved with the LPC synthesis filter impulse response to produce frames or reconstructed voiced speech. A hybrid coder which switches between this pitch synchronous coding scheme for voiced frames and CELP for coding unvoiced speech frames has been tested in simulation. With the parameters quantised to achieve a bit rate of 3.1 kbit/s, good quality decoded speech has been obtained. >
Structural Effects of Carbohydrate-Containing Polycations on Gene Delivery. 3. Cyclodextrin Type and Functionalization (2003)

Linear cationic beta-cyclodextrin (beta-CD)-based polymers can form polyplexes with plasmid DNA and transfect cultured cells. The effectiveness of the gene delivery and the cellular toxicity has been related to structural features in these polycations. Previous beta-CD polycations were prepared from the cocondensation of 6(A),6(D)-dideoxy-6(A),6(D)-diamino-beta-CD monomers with other difunctionalized monomers such as dimethyl suberimidate (DMS). Here, the type of CD and its functionalization are varied by synthesizing numerous 3(A),3(B)-dideoxy-3(A),3(B)-diamino-beta- and gamma-CD monomers. Both alkyl- and alkoxydiamines are prepared in order to vary the nature of the spacing between the CD and the primary amines in the monomers. These diamino-CD-monomers are polymerized with DMS to yield amidine-based polycations. The nature of the spacer between the CD-ring and the primary amines of each monomer is found to influence both molecular weight and polydispersity of the polycations. When these polycations are used to form polyplexes with plasmid DNA, longer alkyl regions between the CD and the charge centers in the polycation backbone increase transfection efficiency and toxicity in BHK-21 cells, while increasing hydrophilicity of the spacer (alkoxy versus alkyl) provides for lower toxicity. Further, gamma-CD-based polycations are shown to be less toxic than otherwise identical beta-CD-based polycations.
Exploring the Platelet Proteome via Combinatorial, Hexapeptide Ligand Libraries (2007)

A combinatorial ligand library, composed of millions of diverse hexapeptide baits, able to capture and concentrate the "low-abundance" proteome while drastically cutting the concentration of the most abundant species, has been applied to the exploration of the soluble platelet proteome. Mass spectrometry analysis of untreated and library-treated platelets has resulted in the identification of 435 unique gene products. Of those, 147 entries (35% of the total) have not been described among the list of >1100 proteins in proteomic platelet investigations reported before. In addition, the analysis of excised spots from two-dimensional electrophoresis analysis allowed 57 other proteins to be added that were not found in LC-MS analysis, 33 of them not described before in proteomics studies, bringing the total number of new gene products to 180. Thus, the present data add a non-negligible number of species for continuing the "cartography" of the proteomic asset of platelets, in view of completing the mapping procedure for a deeper understanding of the physiology and pathology of this blood cell. Because the capturing process is performed under physiological conditions, by exploiting, for binding to the combinatorial library, the native protein configuration, the described technique is not adapted to capture highly hydrophobic proteins, which need strong denaturing and solubilizing conditions that are incompatible with our working procedure. Thus, our list reports essentially hydrophilic proteins, with negative GRAVY indexes.
Theoretical analysis of band structures and lasing characteristics in strained quantum wire lasers (1993)

The lasing characteristics of strained quantum wire lasers are analyzed using a tight binding calculation, and improved dynamic and spectral properties are predicted. An InGaAs quantum wire embedded in a plane of InAlGaAs with the same lattice constant and sandwiched by two-dimensional barrier layers of AlGaAs is considered. In this structure the biaxial strain effect appears together with the two-dimensional confinement effect. The results of the tight binding calculation indicate that the band mixing effect, which inherently exists in the valence bands of GaAs-AlGaAs quantum wires, is suppressed. In addition, the difference between the effective masses of the first conduction band and the first valence band is reduced as compared to the GaAlAs bulk and to GaAs-AlGaAs quantum wells and wires. Thus the advantages of both the quantum wire effect and the strain effect are incorporated in this structure. Calculation of the modulation dynamics and the spectral properties of the strained quantum wire lasers show significant enhancements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The effect of gate metal and SiO2 thickness on the generation of donor states at the Si-SiO2 interface (1985)

Two experimental observations are reported concerning the degradation of the Si–SiO2 interface during electron injection in metal-oxide-semiconductor structures. First, the generation of the interfacial positive charge during avalanche injection can be strongly inhibited by employing magnesium, instead of aluminum, as gate metal, or enhanced by employing gold. This correlates with the different work functions of the metals. Second, during negative bias high-field injection in Al-gate capacitors with thin oxides (≲100 Å), a threshold in gate voltage, of 7–8 V, is found for the generation of the positive charge. Both observations are consistent with a model which assumes that holes generated in the anode by hot electrons, via emission of surface plasmons, are injected into the SiO2 and are subsequently trapped at the Si–SiO2 interface. Other possible mechanisms are also discussed.
Improving DSZOOM's Run Time System (2004)

DSZOOM is a software-based distributed shared memory (DSM) system intended to run on a cluster of computers that communicates through interconnect hardware. In order to run on a multi-system image ...
Investigating the effect of gold kiwifruit consumption on the incidence and symptoms of upper respiratory tract infections in preschool children : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Sciences [sic] in Human Nutrition and Human Health at Massey University, Auckland, New Zealand (2010)

Evidence suggests that diets rich in fruits and vegetables boost the body‟s natural defences against diseases caused by infection. Gold kiwifruit is rich in vitamin C and contains several phytochemicals that may influence immune function. The effect of consumption of ZESPRI® GOLD kiwifruit on the incidence, and symptoms of upper respiratory tract infection (URTI) have been investigated in children attending local crèches and play-centres. In a randomised, crossover trial, 66 children (aged two to five years) were randomised into one of two groups following a 2-week washout period and consumed an equivalent of 2 servings of gold kiwifruit (group A) or 2 servings of banana (group B) daily for 4 weeks. This was followed by a 2-week washout period and a cross-over of the treatments i.e. group A consumed 2 servings of banana and group B consumed 2 servings of gold kiwifruit for a further 4 weeks, followed by a final 2-week washout period. Parents completed a daily questionnaire of URTI symptoms, the validated Canadian Acute Respiratory Illness and Flu Scale (CARIFS), which assessed the incidence of cold-and flu-like illnesses and the severity of those symptoms. The fruit and vegetable consumption of the children along with their food liking was also investigated at baseline and at the end of the intervention. Additionally, children‟s fruit and vegetable eating habits along with their parent‟s motivation to provide them with fruits and vegetables were also investigated. The odds ratio of having a cold- or flu-like illness was 0.55 (95% (0.32, 0.94), P=0.03) for the kiwifruit intervention compared to the banana intervention. The sum of total URTI symptoms scores over the treatment periods were significantly lower for the kiwifruit treatment compared to the banana treatment (P<0.05), along with the incidence of certain URTI symptoms (including cough, headache, and feeling unwell). Children‟s fruit consumption did not differ from baseline to end but their kiwifruit liking scores improved. There was a strong positive correlation between children‟s fruit and vegetable consumption and parents‟ motivation to provide them with fruits and vegetables (r values ranged from 0.22-0.61). In conclusion; Children had a lower incidence of cold- and flu-like illnesses during the kiwifruit intervention phase of the trial compared to banana phase. Some of the URTI symptoms were significantly less during the kiwifruit intervention phase compared to the banana phase. Regular consumption of Zespri® Gold Kiwifruit during the cold & flu season may reduce the incidence or symptoms of URTI in children.
How “Parasites” Serve their Host: A Graphical Analysis of “Scalping” (2003)

Scalpers, as market specialists, may improve ticket-producing firms’ revenues, and the ticket market, when scalpers are relatively limited in number. Thus, both scalpers and firms may have a joint interest in public “scalper regulation” that enhances joint market power. Other market participants may also benefit from a more orderly market.
The use of an antibiotic-impregnated spacer block for revision of the septic total knee arthroplasty. (1991)

Through the use of an antibiotic-impregnated polymethylmethacrylate spacer block in two-stage exchange arthroplasty, the chronically infected total knee arthroplasty can, in most cases, be effectively salvaged. In a review of 28 such consecutive cases by a single surgeon, all revised implants were retained except one which required arthrodesis. In the remaining cases, mean Hospital for Special Surgery knee scores were 86, with mean total range of motion of 90 degrees . All wounds healed eventually, and seven patients were thereafter able to undergo other total joint arthroplasties. Advantages of this technique included maintenance of ligamentous balance as well as bone stock with weight bearing, local antibiotic delivery, and facilitation of reimplantation.
Apoptotic mimicry as a strategy for the establishment of parasitic infections: parasite- and host-derived phosphatidylserine as key molecule (2020)

The establishment of parasitic infection is dependent on the development of efficient strategies to evade the host defense mechanisms. Phosphatidylserine (PS) molecules are pivotal for apoptotic cell recognition and clearance by professional phagocytes. Moreover, PS receptors are able to trigger anti-inflammatory and immunosuppressive responses by phagocytes, either by coupled enzymes or through the induction of regulatory cytokine secretion. These PS-dependent events are exploited by parasites in a mechanism called apoptotic mimicry. Generally, apoptotic mimicry refers to the effects of PS recognition for the initiation and maintenance of pathogenic infections. However, in this context, PS molecules can be recognized on the surface of the infectious agent or in the surface of apoptotic host debris, leading to the respective denomination of classical and non-classical apoptotic mimicry. In this review, we discuss the role of PS in the pathogenesis of several human infections caused by protozoan parasites. Video Abstract.
Increasing Ryanodine Receptor Open Probability Alone Does Not Produce Arrhythmogenic Calcium Waves (2006)

Diastolic waves of Ca 2+ release have been shown to activate delayed afterdepolarizations as well as some cardiac arrhythmias. The aim of this study was to investigate whether increasing ryanodine receptor open probability alone or in the presence of β-adrenergic stimulation produces diastolic Ca release from the sarcoplasmic reticulum (SR). When voltage-clamped rat ventricular myocytes were exposed to caffeine (0.5 to 1.0 mmol), diastolic Ca 2+ release was seen to accompany the first few stimuli but was never observed in the steady state. We attribute the initial phase of diastolic Ca 2+ release to a decrease in the threshold SR Ca 2+ content required to activate Ca 2+ waves and its subsequent disappearance to a decrease of SR content below this threshold. Application of isoproterenol (1 μmol/L) increased the amplitude of the systolic Ca 2+ transient and also the SR Ca 2+ content but did not usually produce diastolic Ca 2+ release. Subsequent addition of caffeine, however, resulted in diastolic Ca 2+ release. We estimated the time course of recovery of SR Ca 2+ content following recovery from emptying with a high (10 mmol/L) concentration of caffeine. Diastolic Ca 2+ release recommenced only when SR content had increased back to its final level. We conclude that increasing ryanodine receptor open probability alone does not produce arrhythmogenic diastolic Ca 2+ release because of the accompanying decrease of SR Ca 2+ content. β-Adrenergic stimulation increases SR content and thereby allows the increased ryanodine receptor open probability to produce diastolic Ca 2+ release. The implications of these results for arrhythmias associated with abnormal ryanodine receptors are discussed.
Chloroplast coupling factor 1: A species-specific receptor for tentoxin (1976)

Tentoxin, a cyclic tetrapeptide, induces chlorosis in certain plant species. It inactivated photophosphorylation and coupling factor 1 (CF(1)) ATPase in lettuce, a sensitive species. This effect was due to binding of tentoxin with CF(1) at a single site (affinity constant 1.3 to 20 x 10(7) M(-1)). Neither AMP nor adenyl-5'-yl imidodiphosphate appeared to bind to this site. In radish, an insensitive species, 20 times more tentoxin was required for 50% inhibition of photophosphorylation. In this species CF(1) ATPase was unaffected by tentoxin, and its CF(1) bound tentoxin only weakly (affinity constant less than 1 x 10(4) M(-1)). Sensitivity of photophosphorylation to tentoxin was correlated with chlorosis sensitivity in six other species examined.