gebhart/patrepeval huggingface dataset:
Sinusoidal endothelium release of hydrogen peroxide enhances very late antigen-4-mediated melanoma cell adherence and tumor cytotoxicity during interleukin-1 promotion of hepatic melanoma metastasis in mice (1997)

The hepatic sinusoidal endothelium (HSE) releases large amounts of reactive oxygen species (ROS) in response to endotoxins and interleukin-1 (IL-1). Such pro-inflammatory mediators have been shown to promote hepatic metastasis. We have investigated the involvement of ROS released by IL-1-stimulated HSE in this promoting effect. Recombinant human interleukin-1 beta (rHuIL-1 beta) (5 micrograms/kg) was intravenously injected into C57BL/6J mice, and the hepatic metastasizing ability of B16 melanoma cells following intrasplenic injection was studied in the presence of ROS scavengers. rHuIL-1 beta-promoted hepatic metastases were significantly (P < .01) reduced by catalase (1 mg/kg) and enhanced by recombinant human superoxide dismutase (rHuSOD) (5 mg/kg). rHuIL-1 beta-stimulated HSE-conditioned medium (HSE-CM) significantly (P < .01) enhanced B16 melanoma cell adhesion to HSE compared with unstimulated HSE-CM, which in turn also significantly (P < .01) increased with melanoma cell adherence compared with basal medium. The addition of catalase completely abrogated proadhesive effects induced by rHuIL-1 beta-stimulated HSE-CM with respect to unstimulated HSE-CM, but did not affect the proadhesive effects induced by unstimulated HSE-CM over basal medium. The rat monoclonal antibody to mouse vascular cell adhesion molecule-1 (VCAM-1) significantly (P < .01) inhibited the enhanced melanoma cell adherence effects of both unstimulated and rHuIL-1 beta-stimulated HSE-CM, indicating that adherence was very late antigen-4 (VLA-4)-mediated. Not surprisingly, the percentage of VLA-4 expressing B16 melanoma cells significantly (P < .05) increased in response to unstimulated (21% of controls) and rHuIL-1 beta-stimulated (32% of controls) HSE-CM. Catalase addition abrogated these effects of rHuIL-1 beta-stimulated-HSE-CM. Melanoma cell damage was observed from the second hour of adhesion to HSE and significantly (P < .01) increased when the cells adhered to rHuIL-1 beta-stimulated HSE. This increase was abrogated by catalase. Cytolysis of the HSE was not observed during melanoma cell adhesion. Neither was the enhancement of B16 melanoma hydrogen peroxide production observed in response to rHuIL-1 beta. Thus, the effects of IL-1 in the liver may consist of a balance between the prometastatic effect of enhanced adherence to the HSE and the antimetastatic effect of H2O2-mediated cytotoxicity. Our results suggest that the enhancement of H2O2 production by the rHuIL-1 beta-stimulated HSE may contribute to the hepatic metastasis progression of ROS-resistant melanoma cells. Results in vitro indicate that this progression is associated with a H2O2-mediated increase in melanoma cell adhesion to HSE.
Mapping quantitative trait loci controlling milk production in dairy cattle by exploiting progeny testing. (1995)

We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny tests based on the milking performances of > 150,000 daughters jointly, was genotyped for 159 autosomal microsatellites bracketing 1645 centimorgan or approximately two thirds of the bovine genome. Using a maximum likelihood multilocus linkage analysis accounting for variance heterogeneity of the phenotypes, we identified five chromosomes giving very strong evidence (LOD score > or = 3) for the presence of a QTL controlling milk production: chromosomes 1, 6, 9, 10 and 20. These findings demonstrate that loci with considerable effects on milk production are still segregating in highly selected populations and pave the way toward marker-assisted selection in dairy cattle breeding.
Targeting the α<sub>9</sub>α<sub>10</sub>nicotinic acetylcholine receptor to treat severe pain (2007)

The alpha9alpha10 nicotinic acetylcholine receptors (nAChRs) are recognized for their function in the hair cells of the inner ear; transcripts for a9 and/or a10 subunits have also been identified in a diverse range of other tissues , including immune cells. The functioning of alpha9alpha10 nAChRs in these latter tissues is unknown. However, a recent series of studies has provided evidence that blockade of the alpha9alpha10 nAChR can alleviate chronic pain resulting from overt peripheral nerve injury or inflammation and increase the functional recovery of damaged neurons. Systemic administration of alpha9alpha10 antagonists produces an acute analgesia; repeated daily administrations produces sustained and cumulative levels of analgesia across 7 days without the development of tolerance. Although the exact mechanism of action is unknown, antagonism of the alpha9alpha10 nAChRs reduces the number of immune cells present at the site of injury.
A Lymphocytopenic Filterable Agent Derived From Tissue Cell Cultures of Murine Carcinoma<xref ref-type="fn" rid="FN2">2</xref> (1965)

A lymphocytopenic virus was isolated from a cell culture derived from a strain of Ehrlich ascites carcinoma and from the mouse passage strain of Ehrlich ascites carcinoma. The virus was not cytopathic in tissue culture but was infective in adult mice in the several strains tested. The major pathologic changes were in the spleen, lymph nodes, and thymus and resulted in a marked diminution of lymphocytes, accompanied by degenerative hepatitis and the development of peritoneal and pleural fluid. The infection was of short duration and was followed by morphologic and functional regeneration of tissue. In the period post infection, the Swiss and C3H mice developed a fibrous encapsulation of the visceral organs. The pathologic changes associated with this virus are different from those known to be associated with mouse hepatitis, and Reo III and murine leukemia viruses.
Tunable terahertz metamaterial absorber based on Dirac semimetal films (2018)

In this paper, the tunable properties of metamaterial absorbers based on 3D Dirac semimetal films (DSFs) in the terahertz (THz) regime are discussed in theory. We consider the absorbers with square-shaped, circular-patch, and cross-shaped resonators. These resonances are theoretically polarization-insensitive at normal incidence because of their 90° rotational symmetry and can achieve perfect absorption in numerical simulation. We then introduce dual-band and broadband absorbers by combining two DSF-based square-shaped (or circular-patch) resonators into one unit cell with different sizes. Unlike with a conventional metal-based absorber, the absorption of a DSF-based absorber can be dynamically tuned by varying the Fermi energy instead of refabricating the structures. Moreover, the DSFs can be regarded as a "Salisbury screen" of an absorber to block the transmission at the THz frequencies, which can be more convenient than graphene in the application of a tunable absorber. Our designs have potential applications in various fields such as sensors, thermal detectors, and imagers.
Parametric Nonlinear Feature Equalization for Robust Speech Recognition (2006)

A new front-end normalization algorithm that uses a parametric nonlinear transformation is proposed in this paper. The method improves histogram equalization based nonlinear transformations by finding a simple and computationally inexpensive parametric expression of the nonlinear transformation. The new parametric approach relies on a two Gaussian model for the probability distribution of the features, and on a simple Gaussian classifier to label the input frames as belonging to the speech or non-speech classes. The result is a more robust equalization, less dependent on the percentage of speech and non-speech frames. Recognition experiments on the AURORA 4 database have been performed and the effectiveness of the algorithm is analyzed in comparison with other linear and nonlinear feature equalization techniques
Regulation of the renal microcirculation by ryanodine receptors and calcium-induced calcium release (2008)

RyR and CICR are important regulations of Ca signaling and contractile tone of renal resistance arterioles in healthy kidneys. The role of this novel-signaling pathway in pathophysiological mechanisms awaits investigation.
Efficient Radio Resource Management with Coalition Games using NOMA in Small Cell Networks (2020)

Future wireless communication systems will see the exponential growth in number of mobile devices and services. Quality of service (QoS) requirement is another aspect of the evolution of wireless communications and the explosive increase in number of devices, makes the fulfillment of this QoS requirement extremely challenging. Hyper dense small cell networks are an integral part of 5G environment. However, they can suffer from high interference and imbalanced distribution of users. Identifying weak users and helping them to achieve standard QoS requirement is a critical issue and challenge to handle. In this work, various technologies namely as joint transmission coordinated multi-point (JT-CoMP), non-orthogonal multiple access (NOMA), multi-user multiple-input multiple-output (MD-MIMO) and zero-forcing beamforming (ZFB) are used along with a cooperative coalition formation game. A static user scenario is developed in simulation environment, and a cooperative coalition game scenario with JT-CoMP is compared with No JT-CoMP, and results indicate the significant overall improvement over it.
GPU accelerate parallel Odd-Even merge sort: An OpenCL method (2011)

Odd-Even merge sort is a basic problem in computer supported cooperative work in design area. However, it is not effective because of the high complexity O(nlg <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> n) in CPU platform. In this paper, we present a novel implementation based on the OpenCL programming model on recent GPU (Graphic Processing Unit). Our implementation was based on Knuth's algorithm and do some change. Due to limitations of OpenCL, we utilize a flag variable to make it avoid the direct backward control flow. As results, our implementation achieves 18× speedups compared with the CPU C++ STL quick sort. And it gets almost linear speedup for next generations of GPU because of the complete parallelism in each iteration process. Meanwhile, our approach makes the odd-even merge sort effectively in practice because of the high performance. Furthermore, the approach used in this paper for cooperating thousands of processing units to parallel process can also be used in other cooperation areas.
Spatial Fourier-transform polarimetry using space-variant subwavelength metal-stripe polarizers (2001)

A novel method for rapid polarization measurement is suggested. The method is based on a periodic space-variant polarizer that can be realized by use of subwavelength metal-stripe gratings. The Stokes parameters of the incident beam are determined by Fourier analysis of the space-variant intensity transmitted through the grating, thus permitting real-time polarization measurement. We discuss the design and realization of such polarizers and demonstrate our technique with polarization measurements of CO(2)-laser radiation at a wavelength of 10.6mum.
Visualization of Flow by Vector Analysis of Multidirectional Cine MR Velocity Mapping (1994)

The potential of MR velocity vector mapping for in vitro and in vivo visualization of flow patterns is demonstrated. Although this study was limited to two-directional flow in a single anatomical plane, the method provides information that might advance our understanding of the human vascular system in health and disease. Further developments to reduce the acquisition time and the handling and presenting of three-directional velocity data are required to enhance the capability of this method.
On the use of low energy misfit dislocation structures to filter threading dislocations in epitaxial heterostructures (1995)

Epitaxial deposits that consist of a substrate and a superlattice with layers alternating between positive and negative misfit are effective at reducing the density of threading dislocations. The superlattice is grown so as to minimize the number of dislocations which thread through the superlattice to the growth surface, i.e., to filter threading dislocations. The thickness of each superlattice layer exceeds a critical thickness for bending threading dislocations into a network of interfacial dislocations accompanied by mutual annihilation of the threading segments of the dislocations. This annihilation process takes place at a finite rate and benefits from annealing each layer of the superlattice before the next layer is grown. The thickness, annealing temperature and time are determined by the misfit between substrate and superlattice, and frictional forces on the dislocations. This process occurs primarily by glide but can also occur by climb. Once the number density of threading dislocations is sufficiently small that the probability of mutual annihilation is practically negligible, then another type of superlattice can be used to further filter the remaining dislocations. This second filter is one of layers whose misfits with the underlying layer are of the same sign. Equations are developed to describe the dislocation filter.
Phosphorylation and O-Glycosylation Sites of Bovine Chromogranin A from Adrenal Medullary Chromaffin Granules and Their Relationship with Biological Activities (1997)

Bovine adrenal medullary chromogranin A, the major soluble component of chromaffin granules, is a phosphorylated glycoprotein. In the present work, phosphorylation and glycosylation sites were determined using mild proteolysis, peptide separation, microsequencing, and mass analysis by electrospray and matrix-assisted laser desorption ionization time-of-flight techniques. Seven post-translational modification sites were detected. Two O-linked glycosylation sites, each consisting of the trisaccharide NeuAcalpha2-3Galbeta1-3GalNAcalpha1, were located in the middle part of the protein, on Ser186 and on Thr231. The former residue is present in the antibacterial peptide named chromacin. Four phosphorylation sites were located on serine residues at positions Ser81 in the N-terminal region of the protein and Ser307, Ser372, and Ser376 in the C-terminal end. One additional phosphorylation site was found on the tyrosine residue at position Tyr173, the N-terminal amino acid of chromacin. With the exception of the phosphorylation on Tyr173, all of the other post-translational modifications are located on highly conserved chromogranin A regions, implying some biological importance.
ADAPTIVE: a flexible and adaptive transport system architecture to support lightweight protocols for multimedia applications on high-speed networks (2003)

This paper describes a high-performance transport system architecture called ADAPTIVE, 'A Dynamically Assembled Protocol Transformation, Integration, and Validation Environment'. The authors are developing ADAPTIVE to support multimedia applications running on high-speed networks. ADAPTIVE is a transformational system providing policies and mechanisms that automatically specify and configure a flexible adaptive transport system. In addition, it provides a controlled prototyping environment for monitoring, analyzing, and experimenting with the effects of different transport system designs and implementations on application performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Use of medicated drops and oral tablets in glaucoma treatment (1996)

This paper addresses the many forms of treatment for glaucoma. We studied particularly the topical drops and oral medications that are most frequently prescribed by ophthalmologists, specifically examining the reasons for the side effects experienced by certain patients taking topical drops and oral medications. Some of the side effects and interactions are discussed, and the importance of proper procedure for application of topical eye drops is stressed. Finally, we emphasize that proper drug usage is critical to the well being of the patient.
Aerodynamics of a vibrated fluid bed (1980)

Abstract Results of an experimental study on the aerodynamics of a vertically vibrated fluidized bed of cross‐section 0.2 × 0.2 m are presented and discussed. Variables studied included frequency (0‐105 s −1 ), amplitude (0‐5xl0 −3 m), bed height (12.5‐100×10 −3 m), particle size (900‐3900 μm), particle density (570‐890 kgm −3 ), particle shape factor (0.55‐1.00) and the particle surface characteristics, i.e. presence of surface moisture. The effect of vibrational parameters on the fluidized bed pressure drop, the newly defined minimum mixing velocity, U mm and overall aerodynamic behaviour of the bed is discussed on the basis of quantitative as well as visual observations. Empirical correlations are proposed for δ P mf and U mm , which were both found to decrease significantly with increase in the vibrational acceleration.
Automobile Navigation System Using Individual Communication Beacon (1991)

<div class="htmlview paragraph">A communication system that uses roadside beacons to broadcast road and traffic information and private messages to vehicles has been developed. The system, called Road/Automobile Communication System (RACS), was the result of a joint research project involving the Public Works Research Institute and 25 private-sector corporations. This paper contains an outline of RACS and of an onboard system developed by TOYOTA and presents the results of field tests conducted in the Tokyo area. The results not only verify the capability of the RACS system and the effectiveness of the in-vehicle equipment but also indicate the potential of such a beacon based network to improve traffic jam and driving safety whilst providing enhanced communication facilities without increasing radio-wave congestion.</div>
Depth of interaction enhanced gamma-ray imaging for medical applications (2006)

Se ha desarrollado un metodo innovador para medir la profundidad de interaccion de rayos-gamma en cristales de centelleo gruesos y continuos. La nueva tecnica consiste en estimar este parametro usando la anchura de la distribucion de luz de centelleo en los cristales que es detectada por un fotomultiplicador. Para su medida rapida y sencilla se ideo una modificacion de muy bajo coste de los circuitos convencionales de division de carga que se usan con gran frecuencia para la determinacion de la posicion del impacto en detectores de rayos-gamma para la Medicina Nuclear. Se presentaron medidas con un detector real, basado en un cristal de LSO de dimensiones de 42mm X 42mm X 10mm y un fotomultiplicador H8500 de Hamamatsu Photonics. La respuesta del detector consiste en los tres momentos no-triviales y el momento trivial. El momento trivial representa normalmente la energia del impacto y los momentos no-triviales son los centroides y el segundo momento. Los experimentos muestran que los centroides no estan afectados por la medida del momento adicional. La resolucion media en estos momentos es menor al 5 %. En los experimentos se observo una resolucion energetica media del 25 % con el valor minimo en el centro del 17 % y el valor maximo en una de las esquinas del 70 %. Se presento un algoritmo para la reconstruccion de la posicion de impacto real a partir de los momentos. Para este fin se uso un modelo analitico de la distribucion de senal, que se verifico experimentalmente. Para los tres momentos no triviales se observo que las predicciones del modelo reproducen muy bien las medidas de estos momentos. Las desviaciones siempre estaban por debajo del 11 %, excepto para el momento trivial. En este ultimo caso, las desviaciones siempre estaban por debajo del 25 %. Se uso el modelo para predecir el comportamiento del detector en 40000 diferentes posiciones de impacto. Los resultados para los dos centroides y el seg
Serum exosomal <i>hnRNPH1</i> mRNA as a novel marker for hepatocellular carcinoma (2017)

These findings suggested that serum exosomal hnRNPH1 mRNA could be an effective marker for HCC in high HBV prevalence areas.
Crop response to applied zinc in ammoniated phosphate fertilizers (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrop response to applied zinc in ammoniated phosphate fertilizersJohn J. MortvedtCite this: J. Agric. Food Chem. 1968, 16, 2, 241–245Publication Date (Print):March 1, 1968Publication History Published online1 May 2002Published inissue 1 March 1968https://pubs.acs.org/doi/10.1021/jf60156a039https://doi.org/10.1021/jf60156a039research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Potent Phagocytic Activity with Impaired Antigen Presentation Identifying Lipopolysaccharide-Tolerant Human Monocytes: Demonstration in Isolated Monocytes from Cystic Fibrosis Patients (2009)

Monocyte exposure to LPS induces a transient state in which these cells are refractory to further endotoxin stimulation. This phenomenon, termed endotoxin tolerance (ET), is characterized by a decreased production of cytokines in response to the proinflammatory stimulus. We have established a robust model of ET and have determined the time frame and features of LPS unresponsiveness in cultured human monocytes. A large number of genes transcribed in tolerant monocytes were classified as either "tolerizable" or "nontolerizable" depending on their expression levels during the ET phase. Tolerant monocytes exhibit rapid IL-1R-associated kinase-M (IRAK-M) overexpression, high levels of triggering receptor expressed on myeloid cells-1 (TREM-1) and CD64, and a marked down-regulation of MHC molecules and NF-kappaB2. These cells combine potent phagocytic activity with impaired capability for Ag presentation. We also show that circulating monocytes isolated from cystic fibrosis patients share all the determinants that characterize cells locked in an ET state. These findings identify a new mechanism that contributes to impaired inflammation in cystic fibrosis patients despite a high frequency of infections. Our results indicate that a tolerant phenotype interferes with timing, efficiency, and outcome of the innate immune responses against bacterial infections.