gebhart/patrepeval huggingface dataset:
NAD(P)H Oxidase 1, a Product of Differentiated Colon Epithelial Cells, Can Partially Replace Glycoprotein 91 <i>phox</i> in the Regulated Production of Superoxide by Phagocytes (2003)

Abstract Reactive oxygen species (ROS) serve several physiological functions; in some settings they act in host defense, while in others they function in cellular signaling or in biosynthetic reactions. We studied the expression and function of a recently described source of ROS, NAD(P)H oxidase 1 or Nox1, which has been associated with cell proliferation. In situ hybridization in mouse colon revealed high Nox1 expression within the lower two-thirds of colon crypts, where epithelial cells undergo proliferation and differentiation. Human multitumor tissue array analysis confirmed colon-specific Nox1 expression, predominantly in differentiated epithelial tumors. Differentiation of Caco2 and HT29 cells with 1α,25-dihydroxyvitamin D3 or IFN-γ enhances Nox1 expression and decreases cell proliferation, suggesting that Nox1 does not function as a mitogenic oxidase in colon epithelial cells. Transduction with retrovirus encoding Nox1 restored activation and differentiation-dependent superoxide production in gp91phox-deficient PLB-985 cells, indicating close functional similarities to the phagocyte oxidase (phox). Furthermore, coexpression of cytosolic components, p47phox and p67phox, augments Nox1 activity in reconstituted K562 cells. Finally, Nox1 partially restores superoxide production in neutrophils differentiating ex vivo from gp91phox-deficient CD34+ peripheral blood-derived stem cells derived from patients with X-linked chronic granulomatous disease. These studies demonstrate a significant functional homology (cofactor-dependent and activation-regulated superoxide production) between Nox1 and its closest homologue, gp91phox, suggesting that targeted up-regulation of Nox1 expression in phagocytic cells could provide a novel approach in the molecular treatment of chronic granulomatous disease.
Benefits and risks of psychiatric medications during pregnancy. (2002)

Traditionally, psychiatric medications were withheld during pregnancy because of fear of teratogenic and other effects. The emergence of evidence of the safety of most commonly used psychiatric medications, the availability of this information in the form of online databases, and the documentation of the adverse effects of untreated maternal mental illness have all increased the comfort of physicians and patients with respect to the use of psychiatric medications during pregnancy. The tricyclic antidepressants and fluoxetine (Prozac) appear to be free of teratogenic effects, and emerging data support similar safety profiles for the other selective serotonin reuptake inhibitors. The mood stabilizers appear to be teratogenic. With the exception of the known risk for depression to worsen in the postpartum period, there is little consistent evidence of the effects of pregnancy on the natural history of mental illness. Decisions regarding the use of psychiatric medications should be individualized, and the most important factor is usually the patient's level of functioning in the past when she was not taking medications.
Intracranial Pressure Waveform Morphology and Intracranial Adaptive Capacity (2008)

P2 elevation is not a reliable clinical indicator to predict an impending disproportionate increase in intracranial pressure.
A new model of phase shifter for its efficient integration in interior point optimal power flow (2009)

Abstract When phase shifters are used as control devices in optimal power flow (OPF), the symmetry of the admittance matrix is destroyed; this introduces some difficulties in the implementation of interior point OPF. This paper presents an efficient approach to handle phase shifters in an interior point OPF algorithm. First, a new power/current injection model of phase shifters is proposed. Then, a detailed explanation of how to integrate this model into the existing interior point OPF code is presented. This integration of phase shifters only requires minor modifications to the existing interior point OPF code by updating Jacobian/Hessian matrices of objective and constraints in each iterate. The distinguished features of the proposed approach are: (i) box constraints are used instead of implicit constraints; (ii) no additional buses are introduced, so the dimensions of Jacobian and Hessian matrices remain the same; and (iii) the admittance matrix is constant, and remains symmetric. Numerical studies on several power systems up to 2383 buses indicate that the proposed approach is simple and efficient. Copyright © 2009 John Wiley & Sons, Ltd.
Human cellular protein patterns and their link to genome DNA sequence data: usefulness of two‐dimensional gel electrophoresis and microsequencing (1991)

Analysis of cellular protein patterns by computer-aided 2-dimensional gel electrophoresis together with recent advances in protein sequence analysis have made possible the establishment of comprehensive 2-dimensional gel protein databases that may link protein and DNA information and that offer a global approach to the study of the cell. Using the integrated approach offered by 2-dimensional gel protein databases it is now possible to reveal phenotype specific protein (or proteins), to microsequence them, to search for homology with previously identified proteins, to clone the cDNAs, to assign partial protein sequence to genes for which the full DNA sequence and the chromosome location is known, and to study the regulatory properties and function of groups of proteins that are coordinately expressed in a given biological process. Human 2-dimensional gel protein databases are becoming increasingly important in view of the concerted effort to map and sequence the entire genome.
On the execution of parallel programs on multiprocessor systems—a queuing theory approach (1990)

The new class of queuing models, called Synchronized Queuing Networks , is proposed for evaluating the performance of multiprogrammed and multitasked multiprocessor systems, where workloads consists of parallel programs of similar structure and where the scheduling discipline is first-come-first-serve. Pathwise evolution equations are established for these networks that capture the effects of competition for processors and the precedence constraints governing tasks executions. A general expression is deduced for the stability condition of such queuing networks under general statistical assumptions (basically the stationarity and the ergodicity of input sequences), which yields the maximum program throughput of the multiprocessor system, or equivalently, the maximum rate at which programs can be executed or submitted. The proof is based on the ergodic theory of queues. Basic integral equations are also derived for the stationary distribution of important performance criteria such as the workload of the queues and program response times. An iterative numerical schema that converges to this solution is proposed and various upper and lower bounds on moments are derived using stochastic ordering techniques.
A Comparison of PMD-Cameras and Stereo-Vision for the Task of Surface Reconstruction using Patchlets (2007)

Recently real-time active 3D range cameras based on time-of-flight technology (PMD) have become available. Those cameras can be considered as a competing technique for stereo-vision based surface reconstruction. Since those systems directly yield accurate 3d measurements, they can be used for benchmarking vision based approaches, especially in highly dynamic environments. Therefore, a comparative study of the two approaches is relevant. In this work the achievable accuracy of the two techniques, PMD and stereo, is compared on the basis of patch-let estimation. As patchlet we define an oriented small planar 3d patch with associated surface normal. Least-squares estimation schemes for estimating patchlets from PMD range images as well as from a pair of stereo images are derived. It is shown, how the achivable accuracy can be estimated for both systems. Experiments under optimal conditions for both systems are performed and the achievable accuracies are compared. It has been found that the PMD system outperformed the stereo system in terms of achievable accuracy for distance measurements, while the estimation of normal direction is comparable for both systems.
Naltrexone and buprenorphine combination in the treatment of opioid dependence (2006)

Naltrexone treatment has demonstrated some advantages for special populations of heroin addicted individuals, but patients' compliance seems to be very poor, with a low adherence and low retention rate. Kappa-opioid system overdrive seems to contribute to opioid protracted abstinence syndrome, with dysphoria and psychosomatic symptoms during naltrexone treatment. The objective of this observational study was to determine the effectiveness of a functional k antagonist in improving naltrexone treatment outcome. A partial mu agonist/kappa antagonist (buprenorphine) and a mu antagonist (naltrexone) were combined during a 12 weeks protocol, theoretically leaving k antagonism as the major medication effect. Sixty patients were submitted to outpatient rapid detoxification utilizing buprenorphine and opioid antagonists. Starting on the fifth day, 30 patients (group A) received naltrexone alone. Alternatively, 30 patients (group B) received naltrexone (50mg oral dose) plus buprenorphine (4 mg sublingual) for the 12 weeks of the observational study. The endpoints of the study were: retention in treatment, negative urinalyses, changes in psychological symptoms (Symptom Checklist-90 Revised: SCL-90) and craving scores (visual analysis scale (VAS)). Thirty-four subjects (56.67%) completed the 12 weeks study. Twenty-one patients (35.0%) had all urine samples negative for opiates and cocaine. nine subjects (15.0%) had urine samples negative for cocaine and opiates for the last 4 weeks of the study. five subjects (8.3%) continued to use cocaine during the 12 weeks of the study. No significant change in pupillary diameter after buprenorphine administration was evidenced during clinical observations from baseline across the weekly measurements. Retention rates in group A (naltrexone) and group B (naltrexone + buprenorphine) at week 12 were respectively 40% (12 patients) and 73.33% (22 patients), with a significant difference in favour of group B (p= 0.018). Patients treated with naltrexone in combination with buprenorphine (B patients) showed a significantly lower rate of positive urines for morphine (4.45%) and cocaine metabolites (9.09%) than those treated with naltrexone alone (A) (25%, morphine; 33.33% cocaine) (p< 0.05; p< 0.05). Irritability, depression, tiredness, psychosomatic symptoms and craving scores decreased significantly less in Group A patients than in group B patients. The dysfunction of opioid system with kappa receptors hyper-activation provoked by heroin exposure, probably underlying dysphoric and psychosomatic symptoms during naltrexone treatment, seems to be counteracted, at least in part, by buprenorphine. The combination of buprenorphine and naltrexone may significantly improve the outcome of opioid antagonists treatment in terms of retention, negative urinalyses, and reduced dysphoria, mood symptoms and craving.
Three-dimensional flow field of a rectangular array of practical air jets (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThree-dimensional flow field of a rectangular array of practical air jetsAbdeally Mohammed and Robert L. ShambaughCite this: Ind. Eng. Chem. Res. 1993, 32, 5, 976–980Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ie00017a030https://doi.org/10.1021/ie00017a030research-articleACS PublicationsRequest reuse permissionsArticle Views196Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Turbo-alternators: a high-availability backup source of energy (2005)

Telecommunication systems require high availability of primary backup power supplies, consisting of generators intended to secure the system against failures of the public mains. In the context of a national program of refurbishment, France Telecom has developed new generators consisting of turbo-alternators designed with a single objective in mind: availability. The authors describe the architecture of a turbo-alternator based power system and its performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Placebo-Controlled Double-Blind Study Examining the Effectiveness of an Hypericum Preparation in 105 Mildly Depressed Patients (1994)

One hundred and five outpatients with mild depressions of short duration were treated in a double-blind study with either 3 x 300 mg hypericum extract or placebo. The therapy phase was 4 weeks. The effectiveness was judged according to the Hamilton Depression Scale after 2 and 4 weeks. The values of the mean basic score in these periods fell from 15.8 to 9.6 or 7.2 in the active group, and in the placebo group, from 15.8 to 12.3 and 11.3. The difference between active and placebo groups were statistically significant with P < .05 and P < .01 achieved after 2 and 4 weeks, respectively. In the active group, 28 of 42 patients (67%) and, in the placebo group, 13 of 47 Patients (28%) responded to treatment. Notable side effects were not found.
Reduced-complexity MSGR-based matrix inversion (2008)

A novel method to significantly reduce the complexity of real-time hardware/software implementations of MSGR-based matrix inversion for MIMO wireless communication systems is presented. It is shown, through extensive simulation of this new technique within a T-BLAST MIMO system, that removing the scale-factor from the MSGR algorithm has no adverse effect on the bit-error rate performance of this practical application. Moreover, this new modification to the MSGR algorithm reduces the number of multiply and divide operations in MSGR-based matrix inversion by 18-19%. Furthermore, it is shown that reduced-precision fixed-point arithmetic may be exploited to further reduce the complexity of the implementation while maintaining acceptable bit-error rate performance.
Effect of chlorhexidine gel treatment on Streptococcus mutans population in human saliva and dental plaque (1981)

The effect of topical application of a 1% chlorhexidine gel on the population of S. mutans in dental plaque and saliva was studied in five subjects highly infected with the organism. After treatment for 5 min daily for 14 d, S. mutans was not detected in three of the subjects and counts of 700 colony-forming units or less per ml of saliva were found in the other subjects. Reappearance of S. mutans was slow and did not reach pretreatment level until 14 weeks or more after therapy. The proportion of S. sanguis in plaque increased temporarily after chlorhexidine treatment, whereas the population of lactobacilli was unaffected. These observations indicate that short-term use of chlorhexidine is of value in controlling oral infection of humans by S. mutans.
Simulation and Assessment of Bioinspired Visual Processing System for Epi-retinal Prostheses (2006)

Retinal prosthesis represents the best near-term hope for individuals with chronic blinding disease of the outer retina. However the small number of stimulating electrodes produces a poor, low resolution image. We propose a new preprocessing method for epi-retinal implants and validate it through a novel simulation of the implanted blind perception. Twenty-one normally sighted, untrained subjects performed a face recognition test. Three different electrodes grids were simulated: rectangular, hexagonal and log-polar. The results show that the proposed pre-processing method has a good and statistically significant performance improvement.
A CMOS LOW-DROPOUT REGULATOR WITH A DYNAMIC-BIASED GAIN STAGE (2012)

This paper presents a CMOS low-dropout (LDO) regulation with a dynamic-biased gain stage. The dynamic-biased gain stage which has the dynamic adjustable output resistance, current and gain is designed as a second stage driving the power transistor. A LDO regulator with the proposed gain stage has been implemented in a 0.18mm standard CMOS process and occupies 0.11mm2 chip area. The experimental results show that the proposed LDO regulator can be stable without any additional on-chip compensation capacitors or complex circuit. The LDO regulator provides a full load transient response of settling time less than 15ms with a 2.2mF load capacitor and the voltage variation is less than 40mV. Furthermore, the load regulation and line regulation are 321mV/mA and 1.8mV/V, respectively.
The Deficit Myth, Modern Monetary Theory and the Birth of the People’s Economy (2021)

"The Deficit Myth, Modern Monetary Theory and the Birth of the People’s Economy." Review of Political Economy, 34(2), pp. 391–392
Joint weighted least squares estimation of frequency and timing offset for OFDM systems over fading channlels (2004)

This paper presents an algorithm for joint estimation of carrier frequency offset and timing frequency offset in orthogonal frequency division multiplexing (OFDM) systems. A weighted least squares algorithm based on a pilot-aided scheme is proposed. The algorithm operates near the Cramer-Rao bound in the variance of estimation errors. Simulations of several estimation algorithms in a multipath fading channel show that this algorithm provides the most accurate estimation in both the carrier frequency offset and the timing frequency offset.
Magnetic Resonance Fluoroscopy Allows Targeted Delivery of Mesenchymal Stem Cells to Infarct Borders in Swine (2003)

Precise targeted delivery of potentially regenerative cellular treatments to recent myocardial infarction borders is feasible with an MR catheter delivery system. MR fluoroscopy permits visualization of catheter navigation, myocardial function, infarct borders, and labeled cells after injection.
Living Labs - the user as co-creator (2007)

The integration of users and other stakeholders into development projects has proved to reduce business risks such as the invention and acceptance of products, services and applications (which do not truly provide added value for customers). However the integration of the end-users remains a difficult task. Thus a new methodological appraoach is required to cope with this problem. Here the emerging European Living Labs offer an unique opportunity for the companies to include end-users in the new product development process. The Living Labs concept is a complete innovation approach which includes all stakeholders in the development process of a product, service or application‥ It refers to an R&D methodology in which innovations, such as service, product or application enhancements, are created and validated in collaborative, multi-contextual, multi-cultural empirical real-world environments. The individual is in focus in his or her role of a citizen, user, consumer or worker. The main difference between traditional consumer research programs and the Living Labs approach is its involvement of the customer in their every day lives, encompassing all of their societal roles.
Asymmetry in first‐price auctions with affiliated private values (2003)

Abstract Collusion and heterogeneity across firms may introduce asymmetry in bidding games. A major difficulty in asymmetric auctions is that the Bayesian Nash equilibrium strategies are solutions of an intractable system of differential equations. We propose a simple method for estimating asymmetric first‐price auctions with affiliated private values. Considering two types of bidders, we show that these differential equations can be rewritten using the observed bid distribution. We establish the identification of the model, characterize its theoretical restrictions, and propose a two‐step non‐parametric estimation procedure for estimating the private value distributions. An empirical analysis of joint bidding in OCS auctions is provided. Copyright © 2003 John Wiley & Sons, Ltd.
Differential Space Time Block Code Scheme for Cooperative Relays in Multi-HOP Sensor Networks (2006)

This work studies the application of differential space time block code (STBC) for wireless multi-hop sensor networks in fading channel. We select multiple sensors as parallel relay nodes to receive and transmit signals from the previous hop. These relay nodes do not exchange symbols with each other but forward the symbols in parallel to the destination using STBCs. The proposed technique has low complexity even when the number of parallel relays grows, since it does not need to track or estimate the time-varying channel coefficients. The steady state network performance measures, such as network throughput and transmission delay, are analyzed via Markov chain modelling. Compared to the traditional single relay routing method, our proposed method offers improved performance.
Benzene‐, Pyrrole‐, and Furan‐Containing Diametrically Strapped Calix[4]pyrroles—An Experimental and Theoretical Study of Hydrogen‐Bonding Effects in Chloride Anion Recognition (2008)

Weak but important: The chloride anion binding properties of diametrically strapped calixpyrroles bearing benzene (see structure), pyrrole, and furan moieties in the strap have been studied in the solid state, in solution, and through theoretical analyses. The results obtained provide support for the notion that CH⋅⋅⋅Cl− hydrogen bonds are significant and contribute substantially to the Cl− binding energetics. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Method to Determine the Turbulence Coefficient of High Rate Gas Reservoir (2012)

The flow regimes included low velocity non-Darcy flow, Darcy flow, inertia flow, and turbulence in some porous media. In abnormal high pressure gas reservoir, the flow velocity was higher than conventional reservoir. Due to turbulence flow, there would be unique flow characteristics in these reservoirs. The deliverability equation of gas well should be expressed by cubic term, containing Darcy term, Visco-Inertial term and turbulence term, instead of Forchheimer’s quadratic equation. The turbulence coefficient, the main parameter in the cubic term, was directly related to the absolute open flow. So far, there is no method to obtain this parameter based on gas field data. Also there is no acceptable correlation for the turbulence coefficient applicable to field conditions. An empirical correlation was established using multiple linear regression method to determine the turbulence coefficient through the Ka Lasu’s well test data. We also calculated the parameters for the other well in this field. The results show that this correlation is more accurate and more useful than the formula established by Ezevdembah on basis of the core data in laboratory.