gebhart/patrepeval huggingface dataset:
Estimating the Specific Productivity Index in Horizontal Wells From Distributed-Pressure Measurements Using an Adjoint-Based Minimization Algorithm (2012)

Summary Recent developments in the deployment of distributed-pressure-measurement devices in horizontal wells promise to lead to a new, low-cost, and reliable method of monitoring production and reservoir performance. Practical applicability of distributed-pressure sensing for quantitative-inflow detection will strongly depend on the specifications of the sensors, details of which were not publicly available at the time of publication. Therefore, we theoretically examined the possibility of identifying reservoir inflow from distributed-pressure measurements in the well. The wellbore and nearwellbore region were described by semianalytical steady-state models, and a gradient-based inversion method was applied to estimate the specific productivity index (SPI) as a function of along-well position. We employed the adjoint method to obtain the gradients, which resulted in a computationally efficient inversion scheme. With the aid of two numerical experiments (one of which was based on a real well and reservoir), we investigated the effects of well and reservoir parameters, sensor spacing, sensor resolution, and measurement noise on the quality of the inversion results. In both experiments, we generated synthetic measurements with the aid of a high-resolution reservoir-simulation model and used these to test the semianalytical inversion algorithm. In the first experiment, we considered a 2000-m horizontal well passing through two 300-m high-permeability streaks in a background with a permeability that was 10 times lower. The location of the streaks and the SPIs along the well were detected with fair accuracy using 20 unknown parameters (SPI values) and 20 pressure measurements. Decreasing the number of measurements resulted in a poorer detection of the streaks and their SPIs. The detection performance also decreased for increasing noise levels and deteriorated sensor resolution, though the negative effect of random measurement noise was cancelled out primarily by stacking multiple measurements. The detrimental effects of measurement noise and low sensor resolution were strongest in areas where the inflow was lowest (usually close to the toe). The second experiment concerned a high-rate near-horizontal well with slightly varying inclination that intersected a dipping package of formations with strongly variable permeabilities. Additionally, a satisfactory detection of SPIs was obtained even though the heterogeneities were no longer perpendicular to the well as in the first experiment. As a result of using the simple semianalytical forward model and the adjoint method, the inversions typically required less than 90 seconds on a standard laptop. This offered the opportunity to extend the algorithm to multiphase flow and dynamic applications (pressure-transient testing), while still maintaining sufficient computational speed to perform the inversion in real time.
SN 2003jd (SN/GRB?) -- X-ray observations. (2003)

SN, 2003jd, (SN/GRB?)
A Negative Regulator of <i>HO</i> Transcription, SIN1 (SPT2), Is a Nonspecific DNA-Binding Protein Related to HMG1 (1991)

The SIN1 gene was initially identified because mutations in SIN1 bypass the need for SWI1 to activate transcription of the yeast HO gene. We show here that transcription of HO in swi1 sin1 cells efficiently utilizes the normal start site. We have cloned SIN1 and found that it is identical to the previously identified gene SPT2, mutations in which allow transcription from certain mutated regulatory regions. The predicted SIN1/SPT2 protein has a distinctive amino acid composition (45% charged residues, 25% basic and 20% acidic) and has similarity to the mammalian HMG1 protein, a nonhistone component of chromatin. We show that SIN1 is concentrated in the nucleus and binds to DNA with little or no sequence specificity in vitro. It thus exhibits properties of an HMG protein. Addition of random DNA segments to a test promoter alters regulation by SIN1 in a manner similar to addition of a segment from the HO upstream region. Functional analysis of certain SIN1 mutations suggests that SIN1 may be part of a multiprotein complex. On the basis of these results, we propose that SIN1 is a nonhistone component of chromatin which creates the proper context for transcription. Because sin1 mutants exhibit increased loss of chromosome III, SIN1 may also play a role in fidelity of chromosome segregation.
Thermal, morphological and spectroscopic studies on cellulose modified with phosphorus, nitrogen, sulphur and halogens (1987)

The kinetics of the thermal degradation of cellulose and modified cellulose, namely, cellulose phosphate, cellulose carbanilate, cellulose tosylate, chlorodeoxycellulose, bromodeoxycellulose, and iododeoxycellulose in air were studied by thermogravimetry and differential thermal analysis from ambient temperature to 700°C. The various thermodynamic functions for different stages of thermal degradation had been obtained following the procedure of Broido. The activation energies for the oxidative decomposition of cellulose and modified celluloses were found to be in the range 30–399 kJ mol−1. The infrared spectra of the residues of modified celluloses gave indication of formation of a compound containing PO, POP (only in the case of cellulose phosphate), CC, and CO groups in the final residual char. The EPR signals indicated the formation of trapped and stable free radicals in the thermal degradation of all the compounds, particularly halodeoxycelluloses showed generation of large amounts of trapped free radicals during the oxidative decomposition. Scanning electron micrographs of the thermally degraded cellulose derivatives show changes in the fibrillar structure, evolution of gasesous products, and film formation depending upon the nature of the substituent in the cellulose matrix. The mechanism of thermal degradation of these compounds has been proposed.
수요견인이 기술혁신에 미치는 영향 (2014)

본 연구는 수요견인이 기술혁신에 미치는 영향을 한국제조업계 회사들의 자료 를 활용하여 회사단위에서 실증 분석하였다. 수요견인에 의한 기술혁신을 계측하 기 위하여 기존 연구에서는 회사 또는 산업 군의 매출액을 사용하였던 것에 비하 여, 본 연구는 회사들의 주력시작의 지리적 위치를 사용하여 수요견인이 기술혁 신에 미치는 영향을 살펴보았다.본 연구는 다음과 같은 결과를 발견하였다.회사 의 주력시장이 국내에 국한된 경우는 해외에 주력시장이 있는 경우보다 기술혁신 활동이 더 적은 것으로 나타났다. 그리고, 해외에 주력시장이 있는 경우에도 선진 국에 주력시장을 가진 경우는 그렇지 않은 경우(개발도상국에만 주력시장을 가진 경우)보다 기술 혁신 활동이 더 활발한 것으로 나타났다.또한, 수요견인이 기술 혁신에 미치는 영향은,제품혁신의 경우 훨씬 더 강하며,공정혁신의 경우에는 더 약하거나 존재하지 않는다는 것을 발견하였다.
Effect of heparin on mesangial cell growth and gene expression of matrix proteins (1998)

Heparin inhibited MC growth and fibronectin production. These effects may, in part, account for the reported beneficial effects of heparin on the course of renal disease in experimental animals.
Novel implementation of 6th order MASH delta-sigma modulators for wideband and multi-standard applications (2002)

This paper presents a novel implementation of a 6th order cascade of lowpass and bandpass MASH /spl Delta//spl Sigma/ modulators architecture intended for wideband and multi-standard applications. It demonstrates the improvement in dynamic range of about 22 dB over its cascade of lowpass stages only counterpart.
A study of blind drawing practice (2000)

Existing drawing tools for blind users give inadequate contextual feedback on the state of the drawing, leaving blind users unable to comprehend and successfully produce graphical information. We have investigated a tactile method of drawing used by blind users that mimics drawing with a pencil and a paper. Our study revealed a set of properties that must be incorporated into drawing tools for blind users, including giving feedback for relocating important points, determining angles, and communicating the overall structure of the drawing. We describe a grid- based model that provides these properties in a primitive- based 2D graphics environment, and we introduce its use in drawing and other graphical interactions.
Two Mantis Shrimps new to the Australian fauna (Crustacea: Stomatopoda: Bathysquillidae) (1988)

Two deep-sea mantis shrimps, Bathysquilla crassispinosa (Fukuda) and B. microps (Manning), arc reported for the first time from Australian Seas, from about 350m and 1000m depths respectively in the Coral Sea.The morphology of the specimens is described and illustrated and the relationships and
Protein-Tyrosine Phosphatase 1B Is Required for HER2/<i>Neu</i>–Induced Breast Cancer (2007)

The protein-tyrosine phosphatase 1B (PTP1B; PTPN1) is an important regulator of mammalian metabolism and also helps control signaling by growth factors, cytokines, and extracellular matrix. Gene knockout studies in mice established PTP1B as a key negative regulator of the insulin and leptin receptors. Experiments using PTP1B(-/-) fibroblast lines, dominant-negative mutants, or small interfering RNAs indicate that PTP1B contributes to dephosphorylation of the epidermal growth factor receptor and platelet-derived growth factor receptors as well. However, PTP1B also may have some positive (signal enhancing) roles downstream of some growth factor receptors and integrins. Previous studies indicated that PTP1B is overexpressed in a significant subset of breast and ovarian cancers, especially in those overexpressing HER2/Neu (HER2(+) tumors). However, experiments using tissue culture cells yield conflicting results on the effects of PTP1B in HER2 signaling, leaving the consequences of PTP1B overexpression for breast carcinogenesis unclear. To determine how PTP1B deficiency affects HER2-evoked breast tumorigenesis, we generated mouse mammary tumor virus (MMTV)-NeuNT transgenic mice lacking one or both alleles of PTP1B. Although heterozygous loss of PTP1B has no effect on tumorigenesis, homozygous PTP1B deficiency dramatically delays or prevents the onset of MMTV-NeuNT-evoked breast tumors. The effects of PTP1B deficiency correlate with defective extracellular signal-regulated kinase activation in preneoplastic mammary glands from compound mutant mice. In contrast, PTP1B deficiency has no effect on MMTV-polyoma middle T tumorigenesis. Our data raise the possibility that PTP1B inhibitors may be chemopreventative for some forms of breast cancer.
Abstract 12631: Peripheral Gamma-aminobutyric Acid(gaba) Signaling in Brown Adipose Tissue Induces Metabolic Dysfunction in Obesity (2015)

Accumulating evidence suggests that adult humans possess active brown adipose tissue (BAT) that may contribute significantly to systemic metabolism because of its high energy consumption capacity. Recently, we demonstrated that metabolic stress induced BAT hypoxia and impaired mitochondrial function, leading to the development of BAT “whitening” and systemic metabolic dysfunction in murine obese models. Various neurotransmitters are known to be involved in the maintenance of BAT homeostasis. Among them, the gamma-aminobutyric acid (GABA) signaling in the central nervous system is well accepted to have anti-obesity effects through the activation of the sympathetic nervous system. Here we show the previously unknown role of peripheral GABA signaling in the development of systemic metabolic dysfunction in obesity. We generated an obese model by imposing a high fat/high sucrose (HFHS) diet on C57BL/6NCr mice. Mass spectrometry analysis demonstrated a significant increase in GABA level in BAT of the dietary obese model. Addition of GABA into drinking water induced BAT whitening, reduced the thermogenic response upon cold tolerance test, and promoted systemic metabolic dysfunction in the obese mice. Mitochondrial calcium is important for the maintenance of mitochondrial homeostasis, whereas calcium overload is reported to inhibit mitochondrial function. Treatment of BAT cells with GABA markedly increased mitochondrial calcium level, promoted the production of reactive oxygen species (ROS), and inhibited mitochondrial respiration. These results indicate that peripheral GABA contributes to the development of systemic metabolic dysfunction by inhibiting BAT function in obesity. The inhibition of peripheral GABA signaling would become a new therapeutic target for obesity and diabetes.
The efficacy of vonoprazan for management of post‐endoscopic submucosal dissection ulcers compared with proton pump inhibitors: A meta‐analysis (2019)

Compared with PPIs, vonoprazan showed a better efficacy in ulcer shrinkage rate and achieved more complete healing in the treatment of post-ESD ulcers. Vonoprazan did not induce any incremental risk of post-ESD bleeding as well. It may be an appropriate choice in the management of artificial ulcers after ESD.
Ring-closure reactions. 12. gem-dimethyl effect in some medium and large rings (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing-closure reactions. 12. gem-dimethyl effect in some medium and large ringsCarlo Galli, Giuseppe Giovannelli, Gabriello Illuminati, and Luigi MandoliniCite this: J. Org. Chem. 1979, 44, 8, 1258–1261Publication Date (Print):April 1, 1979Publication History Published online1 May 2002Published inissue 1 April 1979https://pubs.acs.org/doi/10.1021/jo01322a015https://doi.org/10.1021/jo01322a015research-articleACS PublicationsRequest reuse permissionsArticle Views432Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
EdgePlace: Availability‐aware placement for chained mobile edge applications (2018)

Abstract Mobile edge computing (MEC) literally pushes cloud computing from remote datacenters to the life radius of end users. By leveraging the widely adopted European Telecommunications Standards Institute network function virtualization architecture, MEC provisions elastic and resilient mobile edge applications with proximity. Typical MEC virtualization infrastructure allows a configurable placement policy to deploy mobile edge applications as virtual machines (VMs): affinity can be used to put VMs on the same host for inter‐VM networking performance, whereas anti‐affinity is to separate VMs for high availability. In this paper, we propose a novel model to track the availability and cost impact from placement policy changes of the mobile edge applications. We formulate our model as a stochastic programming problem. To minimize the complexity challenge, we also propose a heuristic algorithm called EdgePlace. With our model, the unit resource cost increases when there are less resources left on a host. Applying affinity would take up more resources of the host but saves network bandwidth cost because of colocation. When enforcing anti‐affinity, experimental results show increases of both availability and interhost network bandwidth cost. For applications with different resource requirements, our model is able to find their sweet points with the consideration of both resource cost and application availability, which is vital in a less robust MEC environment.
Analysis of Impedance and Admittance Data for Solids and Liquids (1977)

Some problems of analyzing small‐signal impedance data on solids or liquids are discussed. A method of using ordinary nonlinear least squares fitting procedures with minor modification to fit at the same time real and imaginary functions of the same set of unknown parameters to complex data is described in detail. This method of complex least squares fitting, which has several advantages over previous approaches, is illustrated by fitting equivalent circuit impedances to some polycrystalline β‐alumina impedance data and to synthetic impedance and admittance data calculated from a theoretical model of the response of homogeneous material with completely blocking electrodes. When different physical processes yield response in overlapping frequency regions so that the different processes lead to some melding of effects in an impedance plane representation, interpretation of equivalent circuit parameters becomes difficult even when the degree of fit of the model to the data is excellent. In particular, low frequency extrapolation in the impedance plane to obtain an estimate of bulk resistance, , in an overlapping completely blocking situation can yield estimates of with very large errors. A method is described of avoiding such errors for both conventional and complex least squares estimation. In essence, one must find and fit the unique equivalent circuit whose elements remain related by invariant formulas to underlying microscopic parameters of the material/electrode system no matter what the degree of phenomena overlap.
Passive microwave receive filter networks using low-Q resonators (2005)

In this article, it has been shown that under certain circumstances, i.e., in a receiver, it is possible to allow microwave filters to have significant passband insertion loss. Systems analysis of various receiver configurations shows that acceptable noise figures and intercept points may be obtained in receivers containing lossy filters, i.e., ones with low-Q resonators. Thus, the engineering problem is how to develop design techniques for filters that have low-Q resonators, but with acceptable response in terms of selectivity and pass-band flatness. A review of several techniques for bandpass and bandstop filters is presented.
In vitro and in vivo real-time imaging with ultrasonic limited diffraction beams (1993)

Recently, there has been great interest in a new class of solutions to the isotropic/homogeneous scaler wave equation which represents localized waves or limited diffraction beams in electromagnetics, optics, and acoustics. Applications of these solutions to ultrasonic medical imaging, tissue characterization, and nondestructive evaluation of materials have also been reported. The authors report a real-time medical imager which uses limited diffraction Bessel beams, X-waves, Axicons, or conventional beams. Results (in vitro and in vivo) show that the images obtained with limited diffraction beams have higher resolution and good contrast over larger depth of field compared to images obtained with conventional focused beams. These results suggest the potential clinical usefulness of limited diffraction beams.
Mechanism Investigations of the Endo Cycloisomerization of Alkynols through Isolation and Characterization of Ruthenium Complexes from the Reactions of Alkynes with a Ruthenium Complex (2011)

In our efforts to probe the reaction mechanism of the endo cycloisomerization of alkynols catalyzed by the complex [Ru(N3P)(OAc)](BPh4) (1; NP3 = N,N-bis[(pyridin-2-yl)methyl][2-(diphenylphosphino)phenyl]methanamine), the reactions of 1 with alkynes were investigated. Several complexes related to intermediates in the catalytic reactions were isolated and characterized. In the presence of DIPEA (N,N-diisopropylethanamine), complex 1 reacted with 3-butyn-1-ol to afford the Ru−oxocyclocarbene complex {Ru(N3P)[═C(CH2)3O](OAc)}(BPh4) (4). Under anhydrous conditions, the reaction of complex 1 with tert-butylacetylene afforded [Ru(N3P)(η3-tBuC≡CC═CHBut)](BPh4) (8). In the presence of water, the reaction of complex 1 with tert-butylacetylene afforded [Ru(N3P)(CO)(η1-CH2But)](BPh4) (13). All the reactions are likely to proceed through ruthenium vinylidene intermediates. These results support that ruthenium vinylidene complexes are involved as the key intermediates in the cycloisomerization of alkynols catalyzed by complex 1.
Functional design verification of the NS32FX16 (2002)

The NS32FX16 imaging/signal processor is specifically optimized for a facsimile and modem applications. This paper gives a description of the functional design verification needs of the NS32FX16 and the FDV tool which was used and made this achievement possible.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Fungal CPCR1 Protein, Which Binds Specifically to β-Lactam Biosynthesis Genes, Is Related to Human Regulatory Factor X Transcription Factors (2000)

Here we report the isolation and characterization of a novel transcription factor from the cephalosporin C-producing fungus Acremonium chrysogenum. We have identified a protein binding site in the promoter of the beta-lactam biosynthesis gene pcbC, located 418 nucleotides upstream of the translational start. Using the yeast one-hybrid system, we succeeded in isolating a cDNA clone encoding a polypeptide, which binds specifically to the pcbC promoter. The polypeptid shows significant sequence homology to human transcription factors of the regulatory factor X (RFX) family and was designated CPCR1. A high degree of CPCR1 binding specificity was observed in in vivo and in vitro experiments using mutated versions of the DNA binding site. The A. chrysogenum RFX protein CPCR1 recognizes an imperfect palindrome, which resembles binding sites of human RFX transcription factors. One- and two-hybrid experiments with truncated versions of CPCR1 showed that the protein forms a DNA binding homodimer. Nondenaturing electrophoresis revealed that the CPCR1 protein exists in vitro solely in a multimeric, probably dimeric, state. Finally, we isolated a homologue of the cpcR1 gene from the penicillin-producing fungus Penicillium chrysogenum and determined about 60% identical amino acid residues in the DNA binding domain of both fungal RFX proteins, which show an overall amino acid sequence identity of 29%.
The trouble with multi-core (2010)

Designers now accept that although transistors will still get smaller and more numerous on each chip, they aren't going to operate faster than they do toady.And if you tried to incorporate all those transistors into one giant microprocessor, you might well end up with a device that couldn't compute any faster than the chip it was replacing, which explains the shift to assembling them into multiple microprocessor cores instead.