gebhart/patrepeval huggingface dataset:
Programmed Death-Ligand 1 Monoclonal Antibody-Linked Immunoliposomes for Synergistic Efficacy of miR-130a and Oxaliplatin in Gastric Cancers (2019)

<b>Aim:</b> PD-L1 monoclonal antibody-conjugated miR-130a/oxaliplatin-loaded immunoliposomes were constructed for enhanced therapeutic efficacy against gastric cancer. <b>Materials & methods</b>: The <i>in vitro</i> antitumor efficacy of the immunoliposomes was evaluated by cell viability, cell invasion, cell apoptosis and western blot analysis and <i>in vivo</i> antitumor efficacy was evaluated in a HGC27-bearing tumor xenograft model. <b>Results:</b> The inhibitory role of miR-130a was demonstrated in HGC27 cells by the downregulation of RAB5A and FOCL1 signaling pathways. Consequently, PD-miOXNP exhibited the strongest anticancer activity <i>in vitro</i> compared with any other formulation. PD-miOXNP showed a significantly higher anticancer efficacy in HGC27 tumors with reduced Ki67<sup>+</sup> cells and increased TUNEL<sup>+</sup> cells for mice group. <b>Conclusion:</b> PD-L1 monoclonal antibody-conjugated immunoliposomes have immense potential to be applied as a next-generation nanomedicine for PD-L1-positive gastric cancers.
Interaction of Insulin with Small Intestinal Epithelial Cells from Developing Rats (1988)

The interaction of insulin with its specific receptors was studied in jejunoileal epithelial cells from 14-, 20-, and 60-day-old rats. Characteristics such as potency and specificity of the insulin receptor system did not vary during development. However, insulin binding decreased with age due to a diminished concentration of insulin receptors, whereas the circulating levels of the hormone followed an inverse evolution. These results support previous suggestions on the potential role of insulin on the mechanisms of differentiation and proliferation of small intestinal mucosa.
Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: Studies <i>in vitro</i> , in animals, and in humans (1998)

A method for measuring DNA synthesis and, thus, cell proliferation, in vivo is presented. The technique consists of administering [6,6-2H2]Glc or [U-13C]Glc, isolating genomic DNA, hydrolyzing enzymatically to free deoxyribonucleosides, and derivatizing for GC-MS analysis of dA or dG isotopic enrichments, or both. Comparison of dA or dG to extracellular Glc enrichment (with a correction for intracellular dilution) reveals the fraction of newly synthesized DNA, by application of the precursor-product relationship. Thus, the technique differs from the widely used [3H]thymidine or BrdUrd techniques in that the de novo nucleotide synthesis pathway, rather than the nucleoside salvage pathway, is used to label DNA; the deoxyribose rather than the base moiety is labeled; purine rather than pyrimidine deoxyribonucleosides are analyzed; and stable isotopes rather than radioisotopes are used. The method is applied here in vitro to the growth of HepG2 and H9 cells in culture; in animals to proliferation of intestinal epithelium, thymus, and liver; and in humans to granulocyte turnover in blood. In all instances, measured cell proliferation kinetics were consistent with expected or independently measured kinetics. The method has several advantages over previously available techniques for measuring cell turnover, involves no radioactivity or potentially toxic metabolites, and is suitable for use in humans. The availability of a reliable and safe method for measuring cell proliferation in humans opens up a number of fundamental questions to direct experimental testing, including basic problems related to cancer, AIDS, and other pathologic states.
An experimental study of insider attacks for OSPF routing protocol (2002)

It is critical to protect the network infrastructure (e.g., network routing and management protocols) against security intrusions, yet dealing with insider attacks are probably one of the most challenging research problems in network security. We study the security threats, especially internal/insider threats, for the standardized routing protocol OSPF. In OSPF, a group of routers collaborate, exchange routing information, and forward packets for each other. If one (and maybe more than one) router is evil or compromised, how can this router damage the whole network? In this paper, we analyze OSPF and identify its strengths and weakness under various insider attacks. Furthermore, to confirm our analysis, we have implemented and experimented one attack, the max sequence number attack, on our OSPF routing testbed. Our attack is very successful against two independently developed router products as it will block routing updates for 60 minutes by simply injecting one bad OSPF protocol data unit.
A resource broker model with integrated reservation scheme (2002)

We present a resource broker model with a new admission control at a single resource level. The admission control supports advance reservation as well as immediate reservation. By separating the brokerage part from the scheduling part, we can obtain fast and constant response time of brokerage requests for resource reservation, modification, allocation and release.
Nonneoplastic Glandular Lesions of the Cervix (2006)

A diverse number of nonneoplastic glandular lesions of the cervix may mimic well-differentiated invasive adenocarcinoma (minimal deviation adenocarcinoma). It is essential for the practicing pathologist to be familiar with the histopathologic spectrum of these lesions to avoid the pitfalls of misinterpretation and inappropriate management of a benign condition. Careful morphologic examination of routinely stained sections is the cornerstone of diagnosis; however, there are cases with atypical features posing a diagnostic challenge where ancillary techniques such as immunohistochemical stains may be of value. This review presents a case of tunnel clusters that illustrate the importance of recognizing benign morphologic features and includes a discussion of other pseudoneoplastic glandular lesions of the uterine cervix commonly encountered in practice.
Fast Handover Authentication Based on Mobility Prediction (2015)

This chapter discusses the characteristics of VANETs and how vehicles are moving on the road. It presents a fast handover authentication scheme based on a vehicle's mobility prediction. First, the chapter introduces a two-layer network architecture based on WiMax and 802.11p, in which broadband wireless Internet access supports both vehicles' safety-related applications and general mobile users' entertainment-related applications. Next, it briefly talks about the multilayer perceptron (MLP) classifier. The proposed seamless authentication scheme is composed of the following four phases: initial vehicle authentication phase, movement prediction phase, preauthentication phase, and handover phase. The chapter analyzes the security properties of the proposed scheme. In particular, it shows how the scheme can effectively resist replay attack and provide forward secrecy. The chapter concludes with a discussion on the performance of the proposed preauthentication scheme.
Principles and applications of selective solar coatings (1975)

Several ways that selective coatings can be used to enhance the performance of solar energy collection systems are reviewed. Coatings discussed include vacuum-deposited, electroplated, and paint-type selective solar absorber coatings and vacuum-deposited and chemically etched antireflection and infrared reflecting coatings for glass. The optical and physical requirements for the coatings, as well as their effectiveness at increasing solar collector performance, are discussed.
OSBP-related Protein 8 (ORP8) Suppresses ABCA1 Expression and Cholesterol Efflux from Macrophages (2007)

ORP8 is a previously unexplored member of the family of oxysterol-binding protein-related proteins (ORP). We now report the expression pattern, the subcellular distribution, and data on the ligand binding properties and the physiological function of ORP8. ORP8 is localized in the endoplasmic reticulum (ER) via its C-terminal transmembrane span and binds 25-hydroxycholesterol, identifying it as a new ER oxysterol-binding protein. ORP8 is expressed at highest levels in macrophages, liver, spleen, kidney, and brain. Immunohistochemical analysis revealed ORP8 in the shoulder regions of human coronary atherosclerotic lesions, where it is present in CD68(+) macrophages. In advanced lesions the ORP8 mRNA was up-regulated 2.7-fold as compared with healthy coronary artery wall. Silencing of ORP8 by RNA interference in THP-1 macrophages increased the expression of ATP binding cassette transporter A1 (ABCA1) and concomitantly cholesterol efflux to lipid-free apolipoprotein A-I but had no significant effect on ABCG1 expression or cholesterol efflux to spherical high density lipoprotein HDL(2). Experiments employing an ABCA1 promoter-luciferase reporter confirmed that ORP8 silencing enhances ABCA1 transcription. The silencing effect was partially attenuated by mutation of the DR4 element in the ABCA1 promoter and synergized with that of the liver X receptor agonist T0901317. Furthermore, inactivation of the E-box in the promoter synergized with ORP8 silencing, suggesting that the suppressive effect of ORP8 involves both the liver X receptor and the E-box functions. Our data identify ORP8 as a negative regulator of ABCA1 expression and macrophage cholesterol efflux. ORP8 may, thus, modulate the development of atherosclerosis.
Multidestination Protocols for Satellite Broadcast Channels (1985)

Two retransmission procedures, the go-back- <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</tex> (GBN) scheme and the selective repeat (SR) scheme, have been analyzed for data transfer from one transmitter to many receivers. We consider transfer of error-controlled bulk data over a satellite broadcast channel. Two retransmission strategies, the dynamic retransmission group reduction (DRGR) technique and the fixed retransmission group (FRG) technique, are proposed. We study the GBN and SR schemes for both strategies. Analytic expressions are derived for the throughput performance of the GBN scheme and of the SR scheme with infinite resources, while discrete event simulation is used to estimate the throughput of the selective repeat scheme with finite resources. Only the SR scheme using the DRGR technique provides acceptable performance for high-speed bulk data transfer. For the DRGR technique, the throughput falls logarithmically with an increase in the number of receivers. In contrast, the throughput for the FRG technique falls exponentially with an increase in the number of receivers.
First-Line Chemotherapy With Cisplatin Plus Fractionated Temozolomide in Recurrent Glioblastoma Multiforme: A Phase II Study of the Gruppo Italiano Cooperativo di Neuro-Oncologia (2004)

The new cisplatin plus bid TMZ regimen appears active in chemotherapy-naive patients with recurrent GBM and incurs an acceptable toxicity.
A CSMA/CD portable data system using adaptive Reed-Solomon coding (2003)

A low-cost carrier sense multiple access/collision detection (CSMA/CD) portable data system for indoor applications is presented. An adaptive forward error control coding scheme using Reed-Solomon (RS) codes is introduced to combat random and burst errors created by noise, interference, and fading occurring in an indoor wireless environment. It is indicated that an adaptive coding scheme is more appropriate to the varying and almost unpredicatable behavior of indoor wireless channels. The performance of the system was evaluated by both analysis and experiments. An experimental CSMA/CD portable data system using a newly developed programmable RS (31,K) codec (encoder/decoder) chip set is described. The use of the programmable RS (31,K) codec for data privacy is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Strategies for minimizing the influence of the use of BYOD and Cloud in organizations: 4CM model (2016)

In the last decade, companies have become tend virtualized thanks to the use of outsourcing, the workforce has become more distributed, workplaces are increasingly distributed and outsourced and increasingly digital employees, with the philosophy of work anytime and anywhere. This development has, and has had a very big impact on mobile platforms and infrastructure, on the one hand, the adoption of the BYOD concept and the use of mobile devices and on the other hand, through the use of cloud computing will have profound implications in the way the technologies are and will be used as well as on the interaction between individuals and these technologies. By applying for a questionnaire and subsequent analysis showed that organizations have a lack of understanding, almost complete, the implications and consequences of using mobile devices and the cloud in organizations. A result of the Focus Group performed we propose the 4CM model.
Value Assignment of Retinol, Retinyl Palmitate, Tocopherol, and Carotenoid Concentrations in Standard Reference Material 2383 (Baby Food Composite) (1999)

In 1997, the National Institute of Standards and Technology (NIST) released Standard Reference Material (SRM) 2383 Baby Food Composite. This SRM can be used as a control material when assigning values to in-house control materials and when validating analytical methods for the measurement of proximates, vitamins, minerals, and trace elements in baby foods and similar matrixes. The Certificate of Analysis for SRM 2383 provides certified and reference values for concentrations of lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, beta-carotene, delta-tocopherol, gamma-tocopherol, alpha-tocopherol, retinol, and retinyl palmitate for 2 types of sample preparation--extraction and saponification. The assigned values were based on the agreement of measurements made by NIST and collaborating laboratories. The Certificate of Analysis also provides reference and information values for concentrations of proximates, minerals, and additional vitamins; assignment of these values is discussed in a companion paper (this issue, page 276).
Wide Tow Marine Seismic Surveys: Parallel or Opposite Sail Lines (1997)

Abstract Wide tow seismic surveys include multiple streamers dragged behind the boat with streamers laterally offset by up to hundreds of meters from the sail line. Each sail line, or pass, thus provides a coverage of a few hundred meters wide. It allows an increase in the pass interval, a reduction in the number of passes and in the acquisition cost. While wide tows are effective to reduce the acquisition cost, they provide data which may be problematic to image. If the acquisition and processing do not take into account the dip-dependent coverage, the output image may have severe amplitude and phase distortions. The problem is that the sub surface coverage of a wide tow pass depends on the subsurface structure. On flat reflectors the reflection point is under the midpoint between shot andreceiver. This provides coverage which extends half way to the outer streamers on each side of the sail line. On dipping reflectors, however, the coverage is wider than half way to the outer streamer for down dip reflectors and narrower than half way for up dip reflectors. This creates problems for the imaging of up dip reflectors. It is therefore recommended to alternate sailing direction between adjacent passes. Thus the narrowing of the coverage of one pass will be compensated by the widening coverage ofits neighbors. Because of variations in shooting directions we require an additional correction for receiver movement. For old data collected before this phenomena had been noticed. or in cases where alternating sailing direction is notdone. advanced processing such as Inversion to Zero Offset (IZO) can produce acceptable results. However, the AVO gradient ay suffer from an acquisition footprint on dipping reflectors. Introduction Increased density of spatial sampling in a cost effective way was made possible for 3D marine seismic surveys by the deployment of multiple sources shooting into a distribution ofmultiple cables. A typical state of the art configuration consists of dual sources and a series of streamers covering a swath of several hundred meters with each boat traverse. In order to understand and quantify the impact of these marine acquisition geometries on final processed data quality, a study was initiatedby Saga Petroleum and Geco-Prakla. Brink and Larssen1 described results from the first phase of this study which focused on the impact of the acquisition geometry on the applicationof DMO techniques. This paper is a continuation of this work. It describes the impact of wide tow marine acquisition on DMO and suggests methods for improvement. Wide towing becomes an issue since seismic data acquired from a single source shooting into a wide cable configuration requires careful handling with regard to the application of processing algorithms which assume 2D geometries and those which are dependent on regular dense spatial sampling. We know that poor spatial sampling adversely affects the performanceof wave equation based processes such as dip move out (DMO) and migration2.
Cost Effectiveness of Revision Total Knee Arthroplasty (2006)

Prognostic study, level II-1 (prospective study). See Guidelines for Authors for complete description of levels of evidence.
Platelet-derived growth factor receptor inhibition reduces allograft arteriosclerosis of heart and aorta in cholesterol-fed rabbits (2003)

The results of the present study suggest that PDGF-R activation may regulate the development of transplant and accelerated arteriosclerosis in hypercholesterolemic rabbits. Thus, PTK inhibitors may provide new strategies for prevention of these fibroproliferative vascular disorders.
Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study (2015)

Krill oil consumption is considered health beneficial as it decreases cardiovascular disease risk parameters through effects on plasma TAGs, lipoprotein particles, fatty acid profile, redox status and possible inflammation. Noteworthy, no adverse effects on plasma levels of TMAO and carnitine were found.
An approach to the diagnosis and remediation of developmental dyslexia using microcomputers (1997)

The diagnosis of developmental dyslexia currently requires considerable clinical expertise which is both costly and time-consuming. The remediation of developmental dyslexia is, at best, difficult for the concerned. The normal diagnostic route is not readily (or easily) available to secondary schools and is almost certainly not within the scope of secondary school budgets. Furthermore, dyslexia is not widely tested for or even recognized by some education authorities. Microcomputers are no longer uncommon in schools and are still an underused resource. We propose an easy to use microcomputer based early screening system that will supplement existing testing strategies. The system that we propose has a secondary purpose. The tests will also provide us with data to help with ongoing research into the remediation and further understanding of dyslexia. We propose that enough data will allow us to develop software that will learn the grammatical mistakes made by a given dyslexic. We call this the dyslexic on a disk approach. The data provided by such software will not only allow the early diagnosis of a widely unrecognized, misunderstood and debilitating disorder but will also support research into the nature of the condition itself. We conclude by illustrating how such software can be built and employed. We propose several techniques for the analysis and possible real time microcomputer based remediation of the problem in hand.
Relaxation Phenomena in Lithium‐Ion‐Insertion Cells (1994)

Relaxation phenomena in lithium‐ion‐insertion cells are modeled. Simulation results are presented for a dual lithium‐ion‐insertion cell and for a cell using a lithium‐foil negative electrode. A period of relaxation after a charge or discharge can cause appreciable changes in the distribution of material in the insertion electrodes. Local concentration cells in the solution phase and an open‐circuit potential that depends on state of charge for the solid phase drive the redistribution of material. Concentration profiles in solid and solution phases during relaxation are analyzed, and the consequences for cell performance are discussed. The model predicts the effects of relaxation time on multiple charge‐discharge cycles and on peak power. Galvanostatic and potentiostatic charging are simulated; the results are compared to experimental data for a commercial battery.
Optimized control strategy for hybrid energy system (2015)

This paper proposes the hybrid energy system control strategy considering the State of Charge (SOC) of battery and the fuel consumption of diesel generator. The hybrid energy system is composed of diesel generator, PV unit, and Energy Storage System (ESS) with battery and supercapacitor. To optimize the fuel consumption of diesel generator it should be operating at the rated power based on the BSFC (Brake Specific Fuel Consumption). And the ESS has to compensate the change of required amount of the load. In this paper, it shows the PSiM modeling of each system and proposes the control strategy for improving the efficiency with considering the SOC of battery.
Structural Safety Analysis Based on Seismic Service Conditions for Butterfly Valves in a Nuclear Power Plant (2014)

The structural integrity of valves that are used to control cooling waters in the primary coolant loop that prevents boiling within the reactor in a nuclear power plant must be capable of withstanding earthquakes or other dangerous situations. In this study, numerical analyses using a finite element method, that is, static and dynamic analyses according to the rigid or flexible characteristics of the dynamic properties of a 200A butterfly valve, were performed according to the KEPIC MFA. An experimental vibration test was also carried out in order to verify the results from the modal analysis, in which a validated finite element model was obtained via a model-updating method that considers changes in the in situ experimental data. By using a validated finite element model, the equivalent static load under SSE conditions stipulated by the KEPIC MFA gave a stress of 135 MPa that occurred at the connections of the stem and body. A larger stress of 183 MPa was induced when we used a CQC method with a design response spectrum that uses 2% damping ratio. These values were lower than the allowable strength of the materials used for manufacturing the butterfly valve, and, therefore, its structural safety met the KEPIC MFA requirements.