gebhart/patrepeval huggingface dataset:
Mesenchymal stem cell carriers enhance antitumor efficacy of oncolytic adenoviruses in an immunocompetent mouse model (2017)

Oncolytic virotherapy represents a promising alternative for cancer treatment; however, viral delivery to the tumor represents a major challenge. Mesenchymal stem cells (MSCs) chemotax to tumors, and can serve as a viral delivery tool. Previously, we demonstrated antitumor therapeutic efficacy for mesenchymal stem cells (MSCs) infected with the oncolytic human adenovirus ICOVIR5 (Celyvir) for treatment of neuroblastoma patients. Given the lack of suitable immunocompetent preclinical models, the mechanism underlying Celyvir antitumor activity remains unknown. In this study, we used the syngeneic murine CMT64 cell line as a human adenovirus-semi-permissive tumor model and demonstrate the homing capacity of mouse Celyvir (mCelyvir) to CMT64 tumors. We found that the combined treatment of mCelyvir and intratumoral injections (i.t.) of ICOVIR5 was more effective than treatment with i.t. ICOVIR5 alone. Interestingly, the superior therapeutic effect of the combined therapy was associated with a higher tumor infiltration of CD8+ and CD4+ T cells. Our findings suggest that the use of MSCs as carriers of oncolytic adenovirus can improve the clinical efficacy of anti-cancer virotherapy, not only by driving the adenovirus to tumors, but also through their potential to recruit T cells.
Cationic Bovine Serum Albumin Based Self‐Assembled Nanoparticles as siRNA Delivery Vector for Treating Lung Metastatic Cancer (2013)

It is generally believed that intravenous application of cationic vectors is limited by the binding of abundant negatively charged serum components, which may cause rapid clearance of the therapeutic agent from the blood stream. However, previous studies show that systemic delivery of cationic gene vectors mediates specific and efficient transfection within the lung, mainly as a result of interaction of the vectors with serum proteins. Based on these findings, a novel and charge-density-controllable siRNA delivery system is developed to treat lung metastatic cancer by using cationic bovine serum albumin (CBSA) as the gene vector. By surface modification of BSA, CBSA with different isoelectric points (pI) is synthesized and the optimal cationization degree of CBSA is determined by considering the siRNA binding and delivery ability, as well as toxicity. The CBSA can form stable nanosized particles with siRNA and protect siRNA from degradation. CBSA also shows excellent abilities to intracellularly deliver siRNA and mediate significant accumulation in the lung. When Bcl2-specific siRNA is introduced to this system, CBSA/siRNA nanoparticles exhibit an efficient gene-silencing effect that induces notable cancer cell apoptosis and subsequently inhibits the tumor growth in a B16 lung metastasis model. These results indicate that CBSA-based self-assembled nanoparticles can be a promising strategy for a siRNA delivery system for lung targeting and metastatic cancer therapy.
Antitumor effects of desmopressin in combination with chemotherapeutic agents in a mouse model of breast cancer. (2008)

The vasopressin peptide analog desmopressin has been used during surgery to prevent bleeding in patients with coagulation defects. Recent experimental and clinical data revealed that perioperative desmopressin therapy can minimize the spread and survival of residual cancer cells. Here, we explored the antitumor effects of desmopressin in combination with chemotherapeutic agents using the F3II mammary carcinoma in syngeneic Balb/c mice. Intravenous administration of desmopressin at a dose of 2 microg/kg together with weekly cycles of carmustine (20 mg/kg) prevented primary tumor infiltration of the skin. Combination of desmopressin with paclitaxel (25 mg/kg) significantly reduced metastatic progression to the lung. Although desmopressin had an antiproliferative effect on F3II cells, in vitro studies did not demonstrate an enhanced cytotoxicity with chemotherapy. Our results suggest that desmopressin may contribute to impair aggressiveness of residual mammary tumors during chemotherapy.
Purification and Characterization of 2-Enoyl-CoA Reductase of <italic>Mycobacterium smegmatis</italic> (1981)

2-Enoyl-CoA reductase was purified to homogeneity for the first time from the crude extract of Mycobacterium smegmatis. Its molecular weight was estimated to be 26,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. NADH acted as an electron donor for the reduction of 2-enoyl-CoA, while NADPH did not. The Km value for NADH was 21.3 microM. On the other hand, NAD inhibited the reaction for competing against NADH, as the Ki value for NAD was 47 microM. Among the enoyl-CoAs used as substrates, those having C10-C16 were found to be most suitable substrates for the purified reductase in terms of both apparent Km and Vmax values. The enzyme was strongly inhibited, however, when the concentration of the C16-substrate was over 50 microM. The enzyme had almost no activity towards substrates having less than C8. When NAD3H was used as an electron donor to 2-dodecenoyl-CoA in the presence of the purified reductase, only laurate was tritiated as the product. Diacetyl and phenylglyoxal, agents that react specifically with arginine, inactivated the reductase in a time- and concentration-dependent manner during the preincubation. These results suggest that some arginine residues in the reductase protein are involved in the enzyme activity.
Éditorial : Tout va très bien, Madame la Marquise (2004)

info:eu-repo/semantics/published
An 8-psec 13dBm peak EIRP digital-to-impulse radiator with an on-chip slot bow-tie antenna in silicon (2014)

In this paper, a direct digital-to-impulse transmitter is implemented that radiates impulses with EIRP of 13dBm and a record pulse-width of shorter than 8psec. It is shown that the starting time of the radiated impulses can be locked to the edge of the input trigger with a high timing accuracy. It is demonstrated that two widely spaced chips can generate coherent impulses in space with timing jitter of better than 270fsec. It is also shown that the frequency stability of the radiated impulses is better than 10Hz at 220GHz. The chip is fabricated in a 130nm SiGe BiCMOS process.
India's family planning programme: a review. (1974)

An evaluation pertaining to the achievement of the objectives of India's family planning program is presented. The general conclusion is that very limited success has been achieved in curbing the birthrate and in creating an awareness of the population problem and of family planning methods among the masses. A gap between knowledge of contraceptive methods and the practice of such methods exists. About 15% of reproductive couples use contraceptive methods, and the birthrate has declined by about 10% from its level of 41.7 per 1000 in 1961. The impact of the family planning program has been much less in rural than in urban areas. There has been an upward trend of age at marriage for women. Immunization and nutrition programs have been undertaken in family welfare planning centers, and treatment for sterile couples and recanalization of sterilized cases have also been given attention in order to emphasize that family planning is meant for family welfare. Equal status for men and women has been pursued so that couples will be content with a small family, regardless of the sex of the children.
Distortion correction of magnetic fields for position tracking (2002)

Electro-magnetic tracking systems are in wide-spread use for measuring 6D positions. However, their accuracy is impaired seriously by distortions of the magnetic fields caused by many types of metal which are omnipresent at real sites. We present a fast and robust method for "equalizing" those distortions in order to yield accurate tracking. The algorithm is based on global scattered data interpolation using a "snap-shot" of the magnetic field's distortion measured once in advance. The algorithm is fast (it does not introduce any further lag in the data flow), robust, the samples of the field's "snap-shot" can be arranged in any way, and it is easy to implement. The distortion is visualized in an intuitive way to provide insight into its nature, and the correction algorithm is evaluated in terms of accuracy and performance. Finally, a qualitative comparison of the susceptibility of a Polhemus and an Ascension tracking system is carried out.
[Soil respiration and its temperature sensitivity among different vegetation types in Beijing mountain area, China.] (2019)

As an important component of terrestrial ecosystem carbon cycle, soil respiration is a hot topic in the studies of carbon cycle. The temperature sensitivity (Q10) of soil respiration is a critical index to estimate the effects of global warming on soil respiration. Understanding Q10 of different vegetation types is of important significance for assessing the carbon budget of forest ecosystems. We examined soil respiration and its temperature sensitivity in three typical forests (Pinus tabuliformis, Platycladus orientalis, and Quercus variabilis) in the Beijing mountainous area by measuring the soil physical and chemical properties, soil temperature, soil moisture, and soil respiration rate (Rs) during the growing season. The results showed that Rs of three typical vegetation types showed a similar trend with changes of soil temperature and humidity, which showed a unimodal pattern, with minimum value (0.45 μmol·m-2·s-1) in early April and maximum value (3.95 μmol·m-2·s-1) in early July. There were significant differences in Rs and Q10 values among the three vegetation types. Soil temperature and humidity were the important factors affecting soil respiration, together they could explain the seasonal variation of soil respiration rate from 48.1% to 56.7%. The range of Q10 value was between 2.05 and 3.19. There was a significant negative correlation between soil organic carbon content and Q10 under each vegetation type (R2>0.9). Vegetation type, elevation, and soil organic carbon content were important drivers for the variation of Q10.土壤呼吸作为陆地生态系统碳循环的重要组成部分,是生态系统碳循环研究中的热点问题.土壤呼吸温度敏感性(Q10)是估算土壤呼吸对全球变暖的反馈参数,研究不同植被类型的Q10对评估森林生态系统碳收支具有重要意义.本研究以北京山区典型植被类型侧柏、油松和栓皮栎为研究对象,通过测定生长季内3种植被类型的土壤理化性质、土壤水热因素以及土壤呼吸速率(Rs)的变化,探究不同植被类型下的土壤呼吸特征及温度敏感性.结果表明:3种主要植被类型的Rs在生长季内与土壤温度、湿度的变化趋势相似,均呈现先升高后降低的单峰变化,Rs在4月初最低(0.45 μmol·m-2·s-1),随后逐渐增大,在7月初达到峰值(3.95 μmol·m-2·s-1),然后逐渐降低,3种植被类型的Rs和Q10值均存在显著差异.土壤温度和湿度是土壤呼吸的重要影响因素,两者与Rs拟合的回归模型可以解析土壤呼吸速率48.1%～56.7%的变化.北京山区的Q10值在2.05～3.19,在同一植被类型下,Q10值与土壤有机碳含量呈显著负相关(R2>0.9),植被类型、海拔和土壤有机碳含量是造成不同植被类型Q10值差异的重要原因.
Antibacterial activity of Aquilaria crassna leaf extract against Staphylococcus epidermidis by disruption of cell wall (2013)

The aqueous extract of Aquilaria crassna leaves possesses an in vitro antibacterial activity against Staphylococcus epidermidis, with no sign of acute oral toxicity in mice, probably by interfering with bacterial cell wall synthesis and inhibiting biofilm formation.
Characteristics of heat flow in optical fiber devices that use integrated thin-film heaters (2000)

We describe the analysis of heat flow in a type of tunable optical fiber grating that uses thin-film resistive heaters microfabricated on the surface of the fiber. The high rate of heat loss from these microstructures and the relatively low thermal diffusivity of the glass yield unusual thermal properties. Approximate one-dimensional analytical calculations capture important aspects of the thermal characteristics of these systems. Comparison with experimental results that we obtained from devices with established designs validates certain features of the computations. This modeling also establishes the suitability of integrated thin-film heaters for several new types of tunable fiber grating devices.
Synthesis of the Antioxidant Glutathione in Neurons: Supply by Astrocytes of CysGly as Precursor for Neuronal Glutathione (1999)

Deficiency of the antioxidant glutathione in brain appears to be connected with several diseases characterized by neuronal loss. To study neuronal glutathione metabolism and metabolic interactions between neurons and astrocytes in this respect, neuron-rich primary cultures and transient cocultures of neurons and astroglial cells were used. Coincubation of neurons with astroglial cells resulted within 24 hr of incubation in a neuronal glutathione content twice that of neurons incubated in the absence of astroglial cells. In cultured neurons, the availability of cysteine limited the cellular level of glutathione. During a 4 hr incubation in a minimal medium lacking all amino acids except cysteine, the amount of neuronal glutathione was doubled. Besides cysteine, also the dipeptides CysGly and gammaGluCys were able to serve as glutathione precursors and caused a concentration-dependent increase in glutathione content. Concentrations giving half-maximal effects were 5, 5, and 200 microM for cysteine, CysGly, and gammaGluCys, respectively. In the transient cocultures, the astroglia-mediated increase in neuronal glutathione was suppressed by acivicin, an inhibitor of the astroglial ectoenzyme gamma-glutamyl transpeptidase, which generates CysGly from glutathione. These data suggest the following metabolic interaction in glutathione metabolism of brain cells: the ectoenzyme gamma-glutamyl transpeptidase uses as substrate the glutathione released by astrocytes to generate the dipeptide CysGly that is subsequently used by neurons as precursor for glutathione synthesis.
Lymphocyte subsets in renal transplant recipients during growth hormone therapy. (1999)

The differential effect of growth hormone treatment on CD4+ and CD8+ lymphocytes might be explained by different expression of the IGF-I receptor in these distinct subsets.
Sparse meshing of uncertain and noisy surface scattered data (2005)

In this paper, we develop a method for generating a high-quality approximation of a noisy set of points sampled from a smooth surface by a sparse triangle mesh. The main idea of the method consists of defining an appropriate set of approximation centers and use them as the vertices of a mesh approximating given scattered data. To choose the approximation centers, a clustering procedure is used. With every point of the input data we associate a local uncertainty measure which is used to estimate the importance of the point contribution to the reconstructed surface. Then a global uncertainty measure is constructed from local ones. The approximation centers are chosen as the points where the global uncertainty measure attains its local minima. It allows us to achieve a high-quality approximation of uncertain and noisy point data by a sparse mesh. An interesting feature of our approach is that the uncertainty measures take into account the normal directions estimated at the scattered points. In particular it results in accurate reconstruction of high-curvature regions.
Notes. A Synthesis of 2-amino-6-trifluoromethylpurine (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes. A Synthesis of 2-amino-6-trifluoromethylpurineCarl Kaiser and Alfred BurgerCite this: J. Org. Chem. 1959, 24, 1, 113–114Publication Date (Print):January 1, 1959Publication History Published online19 May 2003Published inissue 1 January 1959https://pubs.acs.org/doi/10.1021/jo01083a607https://doi.org/10.1021/jo01083a607research-articleACS PublicationsRequest reuse permissionsArticle Views231Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recurrent uterine rupture after abdominal pregnancy (2001)

Uterine rupture can occur at any time throughout gestation. We present a woman with a previous Cesarean section followed by an abdominal pregnancy. In her next pregnancy, complete uterine rupture resulted in an emergency laparotomy. This case is unique in that it gives insight into the variable presentations of uterine rupture and the risks associated with prior Cesarean sections.
A cache-based multiprocessor with high efficiency (1985)

Shared-memory multiprocessors to support concurrent languages for general-purpose multitasked systems are analyzed. To solve the traditional performance problems caused by memory access latency and conflicts, extensive caching of instructions and data is performed in each processor mode. Caches are private to each processor, and coherence is maintained in hardware between the caches. To maintain a good efficiency, several contexts are resident in each processor. On a miss in the cache, a microswitch to another resident context is operated by changing the program counter and a pointer in the register memory. The instruction set of each processor is RISC-like, so that a microswitch should waste few machine cycles. The proposed system has high efficiency, even when the number of processors increases and when the coherence overhead and conflicts are high. Models are developed to evaluate throughput and efficiency.
Selective Conversion of Benzylic C-H Bonds to an Amine Function by Oxidative Nucleophilic Substitution (1988)

The benzylic proton of alkylarenes 1 was replaced by an azido group in one step by reaction with trimethylsilyl azide or hydrazoic acid in chloroform in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The 1-arylalkyl azides 2 were reduced to amines 3, which were characterized as their hydrochlorides 4.
Erythromycin. II. Des-N-methylerythromycin and N-Methyl-C<sup>14</sup>-erythromycin (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTErythromycin. II. Des-N-methylerythromycin and N-Methyl-C14-erythromycinEdwin H. Flynn, Hubert W. Murphy, and Robert E. McMahonCite this: J. Am. Chem. Soc. 1955, 77, 11, 3104–3106Publication Date (Print):June 1, 1955Publication History Published online1 May 2002Published inissue 1 June 1955https://pubs.acs.org/doi/10.1021/ja01616a051https://doi.org/10.1021/ja01616a051research-articleACS PublicationsRequest reuse permissionsArticle Views526Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Unrestrained video-assisted plethysmography: a noninvasive method for assessment of lung mechanical function in small animals (2007)

The assessment of lung mechanical function in small animals, particularly mice, is essential for investigations into the pathophysiology of pulmonary disease. The most accurate and specific methods for making this assessment are highly invasive and so provide data of questionable relevance to normality. By contrast, present noninvasive methods based on unrestrained plethysmography have no direct link to the mechanical properties of the lung. There is thus a need for a completely noninvasive method for determining lung mechanical function in small animals. In the present study, we demonstrate an extension of unrestrained plethysmography in which changes in lung volume are estimated via orthogonal video imaging of the thorax. These estimates are combined with the pressure swings recorded as mice breathe inside a heated and humidified chamber to yield an estimate of specific airway resistance (sRaw). We used this new technique, which we term "unrestrained video-assisted plethysmography" (UVAP), to measure sRaw in 11 BALB/c mice exposed to aerosols of saline, methacholine, and albuterol and obtained mean values of 0.71, 1.23 and 1.10 cmH(2)O x s, respectively. Mean breathing frequency was 4.3, 3.4, and 3.6 breaths/s, respectively, while the corresponding mean tidal volumes were 0.36, 0.44 and 0.37 ml, respectively. We conclude that UVAP, a noninvasive method, is able to provide usefully accurate estimates of sRaw and breathing pattern parameters in mice.
The YAP camera: an accurate gamma camera particularly suitable for new radiopharmaceuticals research (1997)

The YAP Camera represents refined research instrument in nuclear medicine and pharmacology because of its overall detection efficiency comparable to an Anger Camera and its submillimeter intrinsic spatial resolution. The YAP Camera consists of a YAP:Ce multicrystal matrix, whose pillars dimensions are 0.6 mm/spl times/0.6 mm/spl times/10 mm, optically coupled with a position sensitive PMT Hamamatsu R2486 and furnished with a parallel hole lead collimator 20 mm thick with holes diameter of 0.5 mm and septa of 0.15 mm. At this stage it is a miniature camera, with a field of view (FOV) of 40 mm/spl times/40 mm and a total spatial resolution of 1.0-1.2 mm, currently used for radiotracers studies on small biological specimens. A detailed analysis of the detector position linearity and energy responses are presented in this work. The intrinsic spatial resolution is studied with three different single hole collimators (1.0, 0.3, and 0.2 mm), and a theoretical equation is presented. Three different parallel hole collimators are tested to evaluate the optimal hole and septa dimensions. Finally, it is demonstrated that two correction procedures are capable of recovering the image spatial homogeneity and of removing the statistical noise. Some phantom images show the importance of the small-field YAP Camera in the radiopharmacological research.