gebhart/patrepeval huggingface dataset:
L-Aspartic Acid의 무질서하게 분포된 매질에서 파동전개와 변동에 관한 연구 (2012)

L-arpartic acid의 산란혼탁매질에서 형광, 산란과 응집의 영향은 파장과 산란된 형광세기로 나타내는데, laser induced fluorescence(LIF) 분광학에 의한 분자특성으로 나타난다. 산란매질에서 광학적 효과는 광학적 파라미터들( ${\mu}_s$ , ${\mu}_a$ , ${\mu}_t$ )에 의해 표현되고 응집은 고-액상 분리공정에서 ...
Seeing Is Believing: Hot Electron Based Gold Nanoplasmonic Optical Hydrogen Sensor (2014)

We report on the rapid optical detection of gaseous hydrogen using hot electrons generated from resonantly excited substrate-based gold nanohemispheres (Au NHs). We consider hot electron induced H2 dissociation and the subsequent formation of a metastable gold hydride (AuHx) to account for changes in optical transmission. The excitation wavelength was varied to demonstrate a maximum response at the localized surface plasmon resonance (LSPR) wavelength of the AuNHs. Numerical simulations, using the discrete dipole approximation, were employed to corroborate the optical changes associated with the formation of metastable AuHx. Finite time difference domain (FDTD) calculations were also performed to account for the enhanced photocatalytic activity arising due to the confinement of electric fields by the Au NHs. FDTD simulations show that the excitation of the Au NHs plasmon modes generates stronger electric fields at the interface in comparison to a spherical geometry of similar dimensions.
Radiolabeled Anti-CD45 Antibody with Reduced-Intensity Conditioning and Allogeneic Transplantation for Younger Patients with Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome (2014)

We treated patients under age 50 years with iodine-131 ((131)I)-anti-CD45 antibody combined with fludarabine and 2 Gy total body irradiation to create an improved hematopoietic cell transplantation (HCT) strategy for advanced acute myeloid leukemia or high-risk myelodysplastic syndrome patients. Fifteen patients received 332 to 1561 mCi of (131)I, delivering an average of 27 Gy to bone marrow, 84 Gy to spleen, and 21 Gy to liver. Although a maximum dose of 28 Gy was delivered to the liver, no dose-limiting toxicity was observed. Marrow doses were arbitrarily capped at 43 Gy to avoid radiation-induced stromal damage; however, no graft failure or evidence of stromal damage was observed. Twelve patients (80%) developed grade II graft-versus-host disease (GVHD), 1 patient developed grade III GVHD, and no patients developed grade IV GVHD during the first 100 days after HCT. Of the 12 patients with chronic GVHD data, 10 developed chronic GVHD, generally involving the skin and mouth. Six patients (40%) are surviving after a median of 5.0 years (range, 4.2 to 8.3 years). The estimated survival at 1 year was 73% among the 15 treated patients. Eight patients relapsed, 7 of whom subsequently died. The median time to relapse among these 8 patients was 54 days (range, 26 to 1364 days). No cases of nonrelapse mortality were observed in the first year after transplantation. However, 2 patients died in remission from complications of chronic GVHD and cardiomyopathy, at 18 months and 14 months after transplantation, respectively. This study suggests that patients may tolerate myeloablative doses >28 Gy delivered to the liver using (131)I-anti-CD45 antibody in addition to standard reduced-intensity conditioning. Moreover, the arbitrary limit of 43 Gy to the marrow may be unnecessarily conservative, and continued escalation of targeted radioimmunotherapy doses may be feasible to further reduce relapse.
Atomic force microscope of bacteriophage T4 and its tube‐baseplate complex (1993)

Bacteriophage T4 was imaged by atomic force microscopy with the finest resolution to date with a clear image of tail fibers of an estimated diameter of 2-3 nm. T4 phages were spread on a clean surface of silicon wafer and dried under air before observation with an atomic force microscope. The head, tail and tail fibers were routinely imaged with somewhat distorted dimensions. The ease of imaging isolated phage particles with a good resolution raised our expectation for the further use of AFM in biomedical applications.
Arthritis in DBA/1 Mice Induced with Passively Transferred Type II Collagen Immune Serum (1990)

Arthritis was induced in DBA/1 mice by passive transfer of syngeneic anti-type II collagen (CII) serum concentrate. After transfer of serum containing 0.2 or 0.5 mg anti-CII auto-antibodies the first clinical signs of arthritis appeared 48 h after injection. Severe clinical arthritis was detected 96 h after injection. Immunohistochemical analyses of joints 48 h after serum injection revealed synovial foci in intercarpal and metacarpophalangeal joints of macrophage-like cells, expressing C3bi-receptors and major histocompatibility complex class II molecules, and infiltration of few CD4+ lymphocytes. Later (96 h after injection), the inflamed synovia were dominated by C3bi-receptor+ polymorphonuclear cells. In contrast to conventionally induced collagen arthritis (CIA), the inflammatory infiltrates, filling joint spaces and synovial tissue, were extensively dominated by polymorphonuclear cells, whereas macrophage-like cells expressing class II molecules and a few T cells were seen only in the periphery of the developing pannus. The anti-CII serum induced arthritis may be used as a model for studies of humoral mediated mechanisms operating in conventionally induced CIA as well as in rheumatoid arthritis.
Nucleotide sequence of the Escherichia coli regulatory gene mprA and construction and characterization of mprA-deficient mutants (1991)

In high copy number, the Escherichia coli mprA gene reduces the synthesis of peptide microcins B17 and C7 (MccB17 and MccC7) and blocks the osmoinduction of the proU operon at the transcriptional level. mprA has been sequenced and shown to encode a polypeptide of 176 amino acids (Mr, 20,563). Insertion and deletion mutant mprA alleles were constructed and then transferred to the chromosome by allelic replacement. In these mutants, expression of two mcb-lacZ fusions was fivefold derepressed, indicating a negative regulatory role of mprA on the mcb operon (MccB17). In contrast, no effect of the MprA- mutations on the expression of mcc operon (MccC7) or on the osmoinduction of proU operon was observed.
3D virtual pathohistology of lung tissue from Covid-19 patients based on phase contrast X-ray tomography (2020)

We present a three-dimensional (3D) approach for virtual histology and histopathology based on multi-scale phase contrast x-ray tomography, and use this to investigate the parenchymal architecture of unstained lung tissue from patients who succumbed to Covid-19. Based on this first proof-of-concept study, we propose multi-scale phase contrast x-ray tomography as a tool to unravel the pathophysiology of Covid-19, extending conventional histology by a third dimension and allowing for full quantification of tissue remodeling. By combining parallel and cone beam geometry, autopsy samples with a maximum cross section of 8 mm are scanned and reconstructed at a resolution and image quality, which allows for the segmentation of individual cells. Using the zoom capability of the cone beam geometry, regions-of-interest are reconstructed with a minimum voxel size of 167 nm. We exemplify the capability of this approach by 3D visualization of diffuse alveolar damage (DAD) with its prominent hyaline membrane formation, by mapping the 3D distribution and density of lymphocytes infiltrating the tissue, and by providing histograms of characteristic distances from tissue interior to the closest air compartment.
Quality Control in Clinical Laboratories (2011)

1.1 The automated analyzers in clinical laboratories Nowadays, the overwhelming majority of laboratory results in clinical laboratories is being generated by automated analyzers. Modern automated analyzers are highly sophisticated instruments which can produce a tremendous number of laboratory results in a very short time. This is achieved thanks to the integration of technologies from three different scientific fields: analytical chemistry, computer science and robotics. The combination of these technologies substitutes a huge number of glassware equipment and tedious, repetitive laboratory work. As a matter of fact, the laboratory routine work has diminished significantly. Today laboratory personnel’s duties have been shifted from manual work to the maintenance of the equipment, internal and external quality control, instrument calibration and data management of the generated results.
EM-ANN models for microstrip vias and interconnects in dataset circuits (1996)

A novel approach for accurate and efficient modeling of monolithic microwave/millimeter wave integrated circuit (MMIC) components by using electromagnetically trained artificial neural network (EM-ANN) software modules is presented. Full-wave EM analysis is employed to characterize MMIC components. Structures for simulation are chosen using design of experiments (DOE) methodology. EM-ANN models are then trained using physical parameters as inputs and S-parameters as outputs. Once trained, the EM-ANN models are inserted into a commercial microwave circuit simulator where they provide results approaching the accuracy of the EM simulation tool used for characterization of the MIMIC components without increasing the analysis time significantly. The proposed technique is capable of providing simulation models for MMIC components where models do not exist or are not accurate over the desired region of operation. The approach has been verified by developing models for microstrip vias and interconnects in dataset circuits. A new hybrid (/spl Delta/S) modeling approach which makes use of existing approximate models for components is introduced and shown to be a more efficient method for developing EM-ANN models. An example of using EM-ANN models to optimize the component geometry is included.
Sequence Specific Molecular Recognition and Binding by a GC Recognizing Hoechst 33258 Analogue to the Decadeoxyribonucleotide d-[CATGGCCATG]<sub>2</sub>: Structural and Dynamic Aspects Deduced from High Field<sup>1</sup>H-NMR Studies (1990)

The non-exchangeable and imino proton NMR resonances have been assigned of the 1:1 complex of an analogue 2 of Hoechst 33258 1 bound to the decadeoxyribonuycleotide d-[CATGGCCATG]2 by a combination of NOE difference, COSY and NOESYPH techniques. In contrast to Hoechst 33258 which recognizes 5'-AATT sequences exclusively, analogue 2 possesses structural features designed to permit the recognition of GC sites. The NOESY and 1D-NOE experiments place the drug in the minor groove and it is located on the 5'-CCAT sequence. The orientation of the drug in the groove is such as to place the N-methylpiperazine terminus at a GC site. Cross-correlation peaks in the NOESY experiment show that the DNA duplex retains its right-handed B form, similar to that in the free decamer. Specific NOEs locate the benzoxazole moiety on the 5'-CCAT and are consistent with the pyridine nitrogen forming a new hydrogen bond to G(4)-2NH2 at 5'-CCAT. The drug appears to undergo rotation around the C9-C10 bond, at a rate comparable with NMR time scale, even after binding. Variable temperature 1H-NMR studies established that the DNA is thermally stabilized as a result of the drug binding. The drug binding is a dynamic process involving exchange between the equivalent 5'-CCAT sites at approximately 60s-1 with delta G degree of 65 kJ mol-1 at 308K. The experimental evidence is in accord with a slide-swing mechanism for this process.
Structure of the Human 25 kDa FK506 Binding Protein Complexed with Rapamycin (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTStructure of the Human 25 kDa FK506 Binding Protein Complexed with RapamycinJun Liang, Deborah T. Hung, Stuart L. Schreiber, and Jon ClardyView Author Information Department of Chemistry, Cornell University Ithaca, New York 14853-1301 Howard Hughes Medical Institute and Department of Chemistry, Harvard University Cambridge, Massachusetts 02138 Cite this: J. Am. Chem. Soc. 1996, 118, 5, 1231–1232Publication Date (Web):February 7, 1996Publication History Received12 September 1995Published online7 February 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja953139whttps://doi.org/10.1021/ja953139wrapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views341Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Hydrophobicity,Ligands,Monomers,Noncovalent interactions,Peptides and proteins Get e-Alerts
Mutual information based evaluation of 3D building models (2003)

This paper presents a metric based on information theory principles that compares 3D object models to images. The metric is based on the formulation of the mutual information between the model and the images. The technique does not require a priori information about the surface properties of the object and is robust with respect to variations of illumination. As a result the method is quite general and may be used in a wide variety of applications. Experiments are presented that demonstrate the approach by evaluating reconstructed 3D building models in aerial images.
IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients (2003)

Insulin-like growth factors (IGFs) are essential for skeletal muscle development, regeneration, and hypertrophy. Although autocrine actions of IGF-II are known to initiate myoblast differentiation, the regulatory elements and upstream signaling pathways for myogenic expression of IGF-II remain elusive. Here, we report the regulation of IGF-II transcription by mTOR, as well as by amino acid sufficiency, through the IGF-II promoter 3 and a downstream enhancer during C2C12 myoblast differentiation. Furthermore, we present evidence that IGF production, and not IGF signaling, is the primary target for mTOR's function in the initiation of differentiation. Moreover, myogenic signaling by mTOR is independent of its kinase activity and mediated by the PI3K-Akt pathway. Our findings represent the first identification of a signaling pathway that regulates IGF-II expression in myogenesis and implicate the mTOR-IGF axis as a molecular link between nutritional levels and skeletal muscle development.
Path optimization procedures for efficient routing of information after an inter-switch handover (2002)

The cellular packet switch (CPS) is a distributed packet switch proposed for third generation wireless information networks. The infrastructure consists of an IEEE 802.6 Metropolitan Area Networks (MAN) linking base stations, databases, public switches and a cellular controller. Connectivity between MANs is via gateways. The paper addresses issues associated with movement between MANs. Inter-MAN handovers which do not involve the public switched network appear seamless. However, multiple inter-MAN handovers may produce an inefficient information flow among the MANs. The paper discusses the role of gateways in inter-MAN handovers, and path optimization procedures that generate more efficient paths. The path optimization procedures are evaluated based on the following performance criteria: guarantee of sequential delivery, avoidance of multiple copies and delay.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Remote quantification of smokestack effluent mass flow rates using imaging Fourier transform spectrometry (2011)

A Telops Hyper-Cam midwave infrared (1.5 - 5.5μm) imaging Fourier-transform spectrometer (IFTS) was used to estimate industrial smokestack total effluent mass flow rates by combining spectrally-determined species concentrations with flow rates estimated via analysis of sequential images in the raw interferogram cube. Measurements of the coalburning smokestack were made with the IFTS at a stand-off distance of 350m. 185 hyperspectral datacubes were collected on a 128(W)×64(H) pixel sub-window (11.4×11.4cm<sup>2</sup> per pixel) at a 0.5cm<sup>-1</sup> spectral resolution. Strong emissions from H<sub>2</sub>O, CO<sub>2</sub>, CO, SO<sub>2</sub>, and NO were observed in the spectrum. A previously established single-layer radiative transfer model was used to estimate gas concentrations immediately above stack exit, and results compared reasonably with in situ measurements. A simple temporal cross-correlation analysis of sequential imagery enabled an estimation of the flow velocity at center stack. The estimated volumetric flow rate of 106±23m/s was within 4% of the reported value. Final effluent mass flow rates for CO<sub>2</sub> and SO<sub>2</sub> of 13.5±3.8kg/s and 71.3±19.3g/s were in good agreement with in situ rates of 11.6±0.1kg/s and 67.8±0.5g/s. NO was estimated at 16.1±4.2g/s, which did not compare well to the total NO<sub>x</sub> (NO +NO<sub>2</sub>) reported value of 11.2±0.2g/s. Unmonitored H<sub>2</sub>O, HCl , and CO were also estimated at 7.76±2.25kg/s, 7.40±2.00g/s, and 15.0±4.1 g/s respectively.
Congenital Japanese B Encephalitis Infection of Swine (1950)

Summary1. A congenital disease of swine is reported which results in stillbirth or death during the neonatal period. The chief pathologic changes are those of a nonbacterial encephalitis. 2. This disease showed a temporal relationship to epidemics and equine epizootics of Japanese B encephalitis. 3. A virus identified as that of Japanese B encephalitis was recovered from the brain of 3 piglets which died 48 to 72 hours after birth. 4. Congenital damage of the nervous system by an arthropod-borne encephalitis virus has thus been demonstrated in swine.
Largely Typical Patterns of Resting-State Functional Connectivity in High-Functioning Adults with Autism (2013)

A leading hypothesis for the neural basis of autism postulates globally abnormal brain connectivity, yet the majority of studies report effects that are either very weak, inconsistent across studies, or explain results incompletely. Here we apply multiple analytical approaches to resting-state BOLD-fMRI data at the whole-brain level. Neurotypical and high-functioning adults with autism displayed very similar patterns and strengths of resting-state connectivity. We found only limited evidence in autism for abnormal resting-state connectivity at the regional level and no evidence for altered connectivity at the whole-brain level. Regional abnormalities in functional connectivity in autism spectrum disorder were primarily in the frontal and temporal cortices. Within these regions, functional connectivity with other brain regions was almost exclusively lower in the autism group. Further examination showed that even small amounts of head motion during scanning have large effects on functional connectivity measures and must be controlled carefully. Consequently, we suggest caution in the interpretation of apparent positive findings until all possible confounding effects can be ruled out. Additionally, we do not rule out the possibility that abnormal connectivity in autism is evident at the microstructural synaptic level, which may not be reflected sensitively in hemodynamic changes measured with BOLD-fMRI.
Vulnerability of LTE to hostile interference (2013)

LTE is well on its way to becoming the primary cellular standard, due to its performance and low cost. Over the next decade we will become dependent on LTE, which is why we must ensure it is secure and available when we need it. Unfortunately, like any wireless technology, disruption through radio jamming is possible. This paper investigates the extent to which LTE is vulnerable to intentional jamming, by analyzing the components of the LTE downlink and uplink signals. The LTE physical layer consists of several physical channels and signals, most of which are vital to the operation of the link. By taking into account the density of these physical channels and signals with respect to the entire frame, as well as the modulation and coding schemes involved, we come up with a series of vulnerability metrics in the form of jammer to signal ratios. The “weakest links” of the LTE signals are then identified, and used to establish the overall vulnerability of LTE to hostile interference.
Stable distributions, pseudorandom generators, embeddings, and data stream computation (2006)

In this article, we show several results obtained by combining the use of stable distributions with pseudorandom generators for bounded space . In particular:---We show that, for any p ∈ (0, 2], one can maintain (using only O (log n /ϵ 2 ) words of storage) a sketch C(q) of a point q ∈ l n p under dynamic updates of its coordinates. The sketch has the property that, given C(q) and C(s) , one can estimate ‖ q − s ‖ p up to a factor of (1 + ϵ) with large probability. This solves the main open problem of Feigenbaum et al. [1999].---We show that the aforementioned sketching approach directly translates into an approximate algorithm that, for a fixed linear mapping A , and given x ∈ ℜ n and y ∈ ℜ m , estimates ‖ Ax − y ‖ p in O ( n + m ) time, for any p ∈ (0, 2]. This generalizes an earlier algorithm of Wasserman and Blum [1997] which worked for the case p = 2.---We obtain another sketch function C ′ which probabilistically embeds l n 1 into a normed space l m 1 . The embedding guarantees that, if we set m = log(1/δ) O (1/ϵ) , then for any pair of points q , s ∈ l n 1 , the distance between q and s does not increase by more than (1 + ϵ) with constant probability, and it does not decrease by more than (1 − ϵ) with probability 1 − δ. This is the only known dimensionality reduction theorem for the l 1 norm. In fact, stronger theorems of this type (i.e., that guarantee very low probability of expansion as well as of contraction) cannot exist [Brinkman and Charikar 2003].---We give an explicit embedding of l n 2 into l n O (log n ) 1 with distortion (1 + 1/ n Θ(1) ).
Hospitalizations, costs, and mortality among infants with critical congenital heart disease: How important is timely detection? (2013)

Increased CCHD detection at birth hospitals through screening may lead to decreased hospital costs and avoid some deaths during infancy. Additional studies conducted after screening implementation are needed to confirm these findings.
Magnetic Coil Suppression of Visual Perception at an Extracalcarine Site (1996)

Perception of extrafoveal visual targets can be suppressed by magnetic stimulation over the occipital lobes, but the site of interference for this and similar phenomena has not been well defined. We modified a previously used technique to determine the locus of magnetic activation. Using butterfly stimulus coils of different sizes and electric field profiles, we determined a scalp position of minimum threshold and a level of stimulator output that produced 50% error rates for each coil. Intersection of the corresponding electric field profiles in air and in a saline model head was similar and identified superficial occipital cortex rather than the primary visual area as the site of perceptual suppression. Less direct analyses involving the distribution of induced electric fields produced the same conclusion. These results suggest specific hypotheses about the effects of magnetic stimulation on visual physiology.