gebhart/patrepeval huggingface dataset:
The impact of linear and non-linear signal distortions on Galileo code tracking accuracy (2002)

As part of the Galileo Project, ESA is funding many 
activities focusing on trade-offs, implementation and 
performance related to the Specifications of the Galileo 
Signals. The results presented in this paper are extracted from 
a report of signal analysis lead by Astrium Germany [1,2] 
11 in the frame of the Galileo Phase contract [3]. Those 
results aim at supporting the specifications of the interface 
between the Galileo Satellites and the Galileo Signals 
based receivers, and consequently produce some elements 
for Payload and Receivers requirements specifications. 
However, due to the generic approach that has been 
retained, the results applicability is going far beyond the 
Galileo context. 
The degradation of code tracking accuracy parameters due 
to generic linear signal distortions for BOC(m,n)-type 
random signals and non-linear distortions on multiplexed 
signals with non-constant envelope is investigated in 
dependency of distortion parameters. The assessment 
parameters are power loss, correlation loss, S-curve-slope 
and bias. Linear distortions under investigation are 
sinusoidal amplitude ripple, linear amplitude slope, sinusoidal 
phase ripple, quadratic and cubic phase variation, band-
limitation and spurious emission. Non-linear distortion is 
based on a general form of AM-AM and AM-PM for Tricode 
Hexaphase multiplexing, which is the main candidate 
method for non-constant envelope modulation within 
Galileo. Moreover, a specialisation to a third order 
polynomial for the AM-AM envelope transfer characteristic is 
considered. With these types of distortions, the most 
relevant degradations relative to an ideal payload and receiver 
are included. As far as possible, respective investigations 
are based on analytical considerations to get extensively 
applicable statements. But additionally, also base-band 
signal simulations are used.
Synthesis and Antifungal Activity of Rhodopeptin Analogues. 2. Modification of the West Amino Acid Moiety (2000)

Structure-activity relationships of the west amino acid modified analogues of rhodopeptins, novel antifungal tetrapeptide isolated from Rhodococcus species Mer-N1033, have been investigated. Among the analogues synthesized, 2,2-difluoro and 2-hydroxy derivatives retained the antifungal activity with better physical properties, i.e., solubility or acute toxicity.
Multiple heteroepitaxy and superlattice formation of LnBaCuO/YBaCuO system (1989)

Multiple heteroepitaxy and superlattice formation of high-T/sub c/ superconducting films were demonstrated. LnBaCuO/YBaCuO structures (Ln=Er, Nd) were realized as a preliminary stage. Superlattice formation made it clear that the crystal structure of the system strongly depends on the substrate materials. A
Anti-HIV agents. I: Synthesis and in vitro anti-HIV evaluation of novel 1H,3H-thiazolo[3,4-a]benzimidazoles. (1991)

A series of 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles were synthesized by one-pot reaction from o-phenylenediamine, 2-mercaptoacetic acid and a variety of aromatic aldehydes. All compounds obtained were evaluated for antiviral activity against human immunodeficiency virus (HIV). Compounds 4g, 4i, 4j, 4l and 4q exhibit reproducible in vitro anti-HIV activity.
Concept of One-Sided Imaging of SNM Based on Muon-Induced Fission Detection [Slides] (2012)

No abstract prepared.
[The demand for care at a health center according to the regional information system]. (1992)

In spite of the differences in methodology, there are a large number of similarities between several studies.
IL‐3 and Peripheral blood stem cell harvesting (1993)

Transplantation of blood-derived stem cells is increasingly performed because when used alone or when combined with autologous bone marrow grafting, it can demonstrably shorten myelosuppression following multi-agent chemotherapy. Hematopoietic growth factors can mobilize peripheral blood stem cells from the bone marrow to therapeutically intervene in accelerating hematologic recovery. Interleukin 3 (IL-3), whose hematopoietic activities were first described some ten years ago, is one of several candidate growth factors that may prove useful in enhancing this mobilization in order to obtain adequate yields of circulating stem cells for transplantation. IL-3 used in conjunction with synergistically acting cytokines such as granulocyte-macrophage colony stimulating factor (GM-CSF) or granulocyte CSF (G-CSF) have already yielded interesting results, while new factors like stem cell factor are in the process of clinical evaluations and appear promising. However, further issues remain to be clarified to confirm the general applicability of cytokine-augmented peripheral blood stem cells in improving on-schedule delivery of high-dose myelosuppressive chemotherapy in patients with malignancies.
La Cueva Grande: a 43-Megapixel Immersive System (2006)

Los Alamos National Laboratory (LANL) has deployed a 43- megapixel multi-panel immersive environment, La Cueva Grande (LCG), to be used in visualizing the terabytes of data produced by simulations. This paper briefly discusses some of the technical challenges encountered and overcome during the deployment of a 43-million pixel immersive visualization environment.
AKE - the Accelerated k-mer Exploration web-tool for rapid taxonomic classification and visualization (2014)

We show that the execution time of this approach is orders of magnitude shorter than competitive approaches and that accuracy is comparable. The tool is presented to the public as a web application (url: https://ani.cebitec.uni-bielefeld.de/ake/ , username: bmc, password: bmcbioinfo).
Gelation of Aluminum Hydroxide Sols (1987)

The gelation of aluminum hydroxide sols obtained from aluminum sec ‐butoxide has been studied as a function of the conditions of preparation, including pH, temperature, and time of aging. The preceding studies of Yoldas have been extended in more acidic conditions, up to a molar proportion of 1.12 HNO 3 per Al(OC 4 H 9 ) 3 . It has been found that stable sols can easily be obtained by processing at any temperature between 20° and 90°C beyond a molar proportion of 0.28 HNO 3 . The corresponding gels are suggested to have a boehmite‐like structure in which there is a metastable folding of the (020) layers at 20°C, and a stable unfolding at 80°C, the two structures coexisting at intermediate processing temperatures.
Cell-mediated immune responses to vaccine peptides derived from the circumsporozoite protein of <i>Plasmodium falciparum</i> . (1989)

T cell epitopes residing within vaccine candidate peptides have been identified by delayed-type hypersensitivity (DTH) responses in mice. The recombinant sporozoite vaccine candidate, R32tet32, contains at least two T epitopes, one located within the repeat region and another in the tet tail. When C57BL/6 (H-2b) and BALB/c (H-2d) mice were sensitized intradermally with R32tet32 or the truncated protein R32LR emulsified in CFA and challenged 5 days later with R32tet32, only H-2b mice recognized a T epitope located within the major repeat sequence (NANP) and encoded by four or less repeats. H-2d mice responded solely to the T epitope located on the tet tail. Ear swelling was maximal at 48 h and revealed a histologic pattern characteristic of DTH. CD4+ T cell lines derived from immunized animals demonstrated the ability to mediate local DTH, proliferate, and secrete lymphokines in response to stimulation with Ag. High dose i.v. administration of R32tet32 in C57BL/6 and BALB/c mice before intradermal sensitization with R32tet32 revealed that DTH responses were suppressed only in BALB/c mice. Further experiments localized the suppressive determinant to the tet tail. Collectively, these data indicate that DTH may prove to be a useful method to characterize the biologic activity of T epitopes, furthermore they suggest that candidate vaccine peptides should be tested for suppressive activity before inclusion in a vaccine.
Asymmetric Synthesis of α-Amino Acids Based on Carbon Radical Addition to Glyoxylic Oxime Ether (1999)

The first asymmetric synthesis of alpha-amino acids based on diastereoselective carbon radical addition to glyoxylic imine derivatives is reported. The addition of an isopropyl radical, generated from i-PrI, Bu(3)SnH, and Et(3)B in CH(2)Cl(2) at 25 degrees C, to achiral glyoxylic oxime ether 1 proceeded regioselectively at the imino carbon atom of the oxime ether group to give an excellent yield of the C-isopropylated product 2. The competitive reaction using glyoxylic oxime ether 1 and aldoxime ether 4 showed that the reactivity of the glyoxylic oxime ether toward nucleophilic carbon radicals was enhanced by the presence of a neighboring electron-withdrawing substituent. Thus, the alkyl radical addition to glyoxylic oxime ether 1 proceeded smoothly even at -78 degrees C, in contrast to the unactivated aldoxime ether 4. A high degree of stereocontrol in the carbon radical addition to the glyoxylic oxime ether was achieved by using Oppolzer's camphorsultam as a chiral auxiliary. The stannyl radical-mediated reaction of the camphorsultam derivative 6 with an isopropyl radical at -78 degrees C afforded a 96:4 diastereomeric mixture, 7a, of the C-isopropylated product. The reductive removal of the benzyloxy group of the major diastereomer (R)-7a, by treatment with Mo(CO)(6) and the subsequent removal of the sultam auxiliary by standard hydrolysis, afforded the enantiomerically pure D-valine (R)-12 without any loss of stereochemical purity. To evaluate the new methodology, a variety of alkyl radicals were employed in the addition reaction which gave the alkylated products 7 with excellent diastereoselectivity, allowing access to a wide range of enantiomerically pure natural and unnatural alpha-amino acids. Even in the absence of Bu(3)SnH, treatment of 6 with alkyl iodide and Et(3)B at 20 degrees C gave the C-alkylated products 7 with moderate diastereoselectivities. The use of Et(2)Zn as a radical initiator, instead of Et(3)B, was also effective for the radical reaction. The enantioselective isopropyl radical addition to 1 using (R)-(+)-2, 2'-isopropylidenebis(4-phenyl-2-oxazoline) and MgBr(2) gave excellent chemical yield of the valine derivative 2 in 52% ee.
Chemical agent resistant coating (CARC) detection using Hyper-Spectral Imager (HSI) and a newly developed Feature Transformation (FT) detection method (2015)

Chemical Agent Resistant Coating (CARC) is the term for the paint commonly applied to military vehicles which provides protection against chemical and biological weapons. In this paper, we present results for detecting CARC with two different colors (Green and Beige). A High-Fidelity Target Insertion Method has been developed. This method allows one to insert the target radiance into any HSI sensor scene, while still to preserve the sensor spatio-spectral noise at all the pixel positions. We show that the reduced (400-1,000nm) spectral range is good enough for Beige CARC, and Green CARC Type I and II detection using several current state-of-the-art HSI target detection methods. Furthermore, we will present a newly developed Feature Transformation (FT) algorithm. In essence, the FT method, by transforming the original features to a different feature domain (e.g., the Fourier, wavelet packets, and local cosine domains), may considerably increase the statistic separation between the target and background probability density functions, and thus may significantly improve the target detection and identification performance, as evidenced by the test results in this paper. We show that by differentiating the original spectral features (this operation can be considered as the 1st level Haar wavelet high-pass filtering), we can completely separate Beige CARC from the background using a single band at 650nm, and completely separate Green CARC from the background using a single band at 1180nm, leading to perfect detection results. We have developed an automated best spectral band selection process that can rank the available spectral bands from the best to the worst for target detection. Finally, we have also developed an automated crossspectrum fusion process to further improve the detection performance in lower spectral range (<1,000nm) by selecting the best spectral band pair.
Image reconstruction from a limited number of projections using multiple object detection/estimation (2002)

An algorithm which approximates the maximum likelihood estimator (MLE) for the locations of constant-density discs in integral projection data is presented. The algorithm is of linear complexity in the object count and requires only approximately 25% more computation than the MLE of the single-location problem. Approximation error analysis, in terms of error probability, is provided through empirical matching of densities for the extremal values of the random-noise field.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Increased haemorrhagic risk after repeated infusion of highly substituted medium molecular weight hydroxyethyl starch. (1997)

Infusion of the large volumes of high molecular weight hydroxyethyl starch (HES) has been know to lead to coagulation disorders. Medium molecular starch is considered a safe alternative, even after repeated administration. In 10 patients with cerebrovascular diseases, a 10-day hemodilution was carried out using 10% HES 200/0.62. Initially, a loading dose of 500 ml was administered once over 45-60 min, followed by 500 ml maintenance dose per day for 10 days. Its high intravascular molecular weight (120,000 D) showed that cleavage of the starch is slowed due to the higher degree of substitution. The continuous increase of HES-serum concentration to 27.7 mg/ml gave evidence of a cumulation of poorly degradable molecules. Although this caused a prolonged volume effect, plasma viscosity and erythrocyte aggregation were influenced in an unfavourable way. The negative effects were not evident in their influence on the coagulation system. Under therapy, a significant 42.8% increase (p < 0.01) in activated partial thromboplastin time occurred. Factor VIII:C, von Willebrand ristocetin co-factor and von Willebrand factor antigen dropped during the therapy below the hemostasiological limit of 30% (p < 0.01), and in some patients below 10%. A high degree of substitution, particularly after repeated infusion, leads to a cumulation of large molecules that are difficult to break down and which unfavourably affect rheological and hemostasiological parameters.
Preclinical Evaluation of the Immunogenicity and Safety of an Inactivated Enterovirus 71 Candidate Vaccine (2013)

Human enterovirus 71 (EV71) is a significant cause of morbidity and mortality from Hand, Foot and Mouth Disease (HFMD) and neurological complications, particularly in young children in the Asia-Pacific region. There are no vaccines or antiviral therapies currently available for prevention or treatment of HFMD caused by EV71. Therefore, the development of therapeutic and preventive strategies against HFMD is of growing importance. We report the immunogenic and safety profile of inactivated, purified EV71 preparations formulated with aluminum hydroxide adjuvant in preclinical studies in mice and rabbits. In mice, the candidate vaccine formulations elicited high neutralizing antibody responses. A toxicology study of the vaccine formulations planned for human use performed in rabbits showed no vaccine-related pathological changes and all animals remained healthy. Based on these preclinical studies, Phase 1 clinical testing of the EV71 inactivated vaccine was initiated.
Redox, Radiation, and Reductive Bioactivation (1992)

A brief review is presented of the background to, and the principles involved in, the development of redox-sensitive drugs for use in cancer therapy. The role of redox processes in the action of various types of radiosensitizers and in the activation of bioreductive drugs is described. The mechanisms by which many simple hypoxic cell radiosensitizers act are believed to involve fast electron transfer processes involving DNA. Some of these agents can also function as hypoxic cell cytotoxins, although the mechanisms involved are different. These "bioreductive drugs" are activated by intracellular metabolic reduction mediated through various cellular reductases. Usually, though not always, bioreduction is favored under hypoxic conditions, and this is why many of these compounds display differential cytotoxicity to hypoxic cells. This is one of the rationales for selectivity in solid tumors. The potencies of both hypoxic cell radiosensitizers and bioreductive drugs are strongly correlated with their electron affinities. Classes of bioreductive agents of current interest are described briefly. These include simple and dual-function nitroheterocycles including the highly potent compound RB-6145, quinone-based drugs including analogues of mitomycin C, and heterocyclic compounds containing N-oxide functions. The study of bioreductive agents for potential use as adjuncts for various approaches to cancer treatment is described.
Polymerization of amphiphilic dienes in Langmuir-Blodgett multilayers (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymerization of amphiphilic dienes in Langmuir-Blodgett multilayersA. Laschewsky and H. RingsdorfCite this: Macromolecules 1988, 21, 7, 1936–1941Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ma00185a010https://doi.org/10.1021/ma00185a010research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Stem Cell Bioengineering (2001)

Tissue engineering and cellular therapies, either on their own or in combination with therapeutic gene delivery, have the potential to significantly impact medicine. Implementation of technologies based on these approaches requires a readily available source of cells for the generation of cells and tissues outside a living body. Because of their unique capacity to regenerate functional tissue for the lifetime of an organism, stem cells are an attractive "raw material" for multiple biotechnological applications. By definition they are self-renewing because on cell division they can generate daughter stem cells. They are also multipotent because they can differentiate into numerous specialized, functional cells. Recent findings have shown that stem cells exist in most, if not all, tissues, and that stem cell tissue specificity may be more flexible than originally thought. Although the potential for producing novel cell-based products from stem cells is large, currently there are no effective technologically relevant methodologies for culturing stem cells outside the body, or for reproducibly stimulating them to differentiate into functional cells. A mechanistic understanding of the parameters important in the control of stem cell self-renewal and lineage commitment is thus necessary to guide the development of bioprocesses for the ex vivo culture of stem cells and their derivates.
Diffraction semblance for velocity and structure analysis (1987)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1987Diffraction semblance for velocity and structure analysisAuthors: Charles J. SickingCharles J. SickingARCO Oil & Gas Co.https://doi.org/10.1190/1.1891979 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1891979FiguresReferencesRelatedDetailsCited ByChapter 6 Pre-Drill Geophysical Methods for Geopressure Detection and EvaluationA new method for the migration velocity analysis of noisy seismic dataSignal Processing, Vol. 15, No. 3 SEG Technical Program Expanded Abstracts 1987ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1987 Pages: 923 publication data© 1987 Copyright © 1987 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 07 Mar 2005 CITATION INFORMATION Charles J. Sicking, (1987), "Diffraction semblance for velocity and structure analysis," SEG Technical Program Expanded Abstracts : 424-426. https://doi.org/10.1190/1.1891979 Plain-Language Summary PDF DownloadLoading ...
Similar, but not identical, modulation of expression of extracellular matrix components during in vitro and in vivo aging of human skin fibroblasts (1992)

Regulation of the synthesis of procollagen and other extracellular matrix components was examined in human skin fibroblasts obtained from donors of various ages, from fetal to 80 years old (in vivo aged), and in fetal fibroblasts at varying passage levels (in vitro aged). Growth rates and saturation densities of fibroblasts decreased with increasing age of the donor and after passage 20 of fetal fibroblasts. The rates of collagen and proteoglycan synthesis also decreased during both types of aging to about 10-25% of the rate in early passage fetal fibroblasts, whereas the synthesis of total noncollagenous proteins was not greatly affected. Decreased collagen synthesis in both types of aging was correlated with lower steady-state levels of mRNAs for the two subunits of type I procollagen mRNA, although their regulation was not coordinate. Type III collagen mRNA levels also declined in both types of aging. The concentration of fibronectin mRNA also decreased during in vitro aging but more rapidly than the collagen mRNAs, whereas in fibroblasts from 51-80-year-old donors, it was similar to or higher than in early passage fetal fibroblasts. This study suggests that the decreased synthesis of procollagen and proteoglycans in in vivo aged fibroblasts represents changes that are responsible for intrinsic degenerative changes that occur in human skin during aging. Furthermore, although in vitro and in vivo aging were similar in many respects, they were not equivalent, as evidenced by the differences in regulation of fibronectin expression.
A review of lunar and planetary magnetic field measurements using space probes. (1965)

Planetary magnetic field boundaries and field interactions with solar wind determined from data obtained by space probes near Moon, Venus and Mars