gebhart/patrepeval huggingface dataset:
Development of a Radio Enabler for Reconfiguration Management within the IEEE P1900.4 Working Group (2007)

An important emerging capability is for mobile terminals to be dynamically reconfigured. Through ongoing advances in technology such as software defined radio, reconfiguration of mobile terminals will in the near future be achievable across all layers of the protocol stack. However, along with the capability for such wide-ranging reconfiguration comes the need to manage reconfiguration procedures. This is necessary to coordinate reconfigurations, to ensure that there are no negative effects (e.g. interference to other RATs) as a result of reconfigurations, and to leverage maximal potential benefits of reconfiguration and ensuing technologies such as those involving dynamic spectrum access. The IEEE P1900.4 working group is therefore defining three building blocks for reconfiguration management: network reconfiguration management (NRM), terminal reconfiguration management (TRM), and a radio enabler to provide connectivity between the NRM and TRMs. In this paper we concentrate on aspects of the radio enabler, highlighting its relevance in heterogeneous radio access scenarios, its advantages, and some aspects of its technical realization.
SOS Phosphorylation and Disassociation of the Grb2-SOS Complex by the ERK and JNK Signaling Pathways (1996)

Insulin activation of Ras is mediated by the plasma membrane targeting of the guanylnucleotide exchange factor SOS associated with the small adapter protein Grb2. SOS also lies in an insulin-stimulated feedback pathway in which the serine/threonine phosphorylation of SOS results in disassociation of the Grb2-SOS complex thereby limiting the extent of Ras activation. To examine the relative role of the mitogen-activated protein kinases in the feedback phosphorylation of SOS we determined the signaling specificity of insulin, osmotic shock, and anisomycin to activate the ERK (extracellular-signal regulated kinase) and JNK (c-Jun kinase) pathways. In Chinese hamster ovary cells expressing the human insulin receptor and murine 3T3L1 adipocytes, insulin specifically activated ERK with no significant effect on JNK, whereas anisomycin specifically activated JNK but was unable to activate ERK. In contrast, osmotic shock was equally effective in the activation of both kinase pathways. Insulin and osmotic shock, but not anisomycin, resulted in SOS phosphorylation and disassociation of the Grb2-SOS complex, demonstrating that the JNK pathway was not involved in the insulin-stimulated feedback uncoupling of the Grb2- SOS complex. Both the insulin and osmotic shock-induced activation of ERK was prevented by treatment of cells with the specific MEK inhibitor (PD98059). However, expression of dominant-interfering Ras (N17Ras) inhibited the insulin- but not osmotic shock-stimulated phosphorylation of ERK and SOS. These data demonstrate that activation of the ERK pathway, but not JNK, is responsible for the feedback phosphorylation and disassociation of the Grb2-SOS complex.
Medical Surveillance following Radiation Over-Exposure (1970)

This paper describes the medical surveillance following an incident at D.E.R.E. when two reactor operators received radiation doses above that permitted. The doses received were similar to what might be expected in accidental exposure to a gamma radiographic source or in an accident where a radiographer entered a room in which an industrial X-ray set was still operating.
Hydrophobic Interactions as Substitutes for a Conserved Disulfide Linkage in the Type IIa Bacteriocins, Leucocin A and Pediocin PA‐1 (2008)

High and dry: Three analogues of leucocin A (shown in figure) and six analogues of pediocin PA-1 were synthesized in which conserved cysteines that form a disulfide bond were replaced by pairs of hydrophobic amino acids. Noncovalent hydrophobic interactions in all of the LeuA derivatives effectively replaced the disulfide and afforded peptides with full antimicrobial activity. In contrast, all of the Ped derivatives were inactive except for 5 d.
Lithium Chloride:  An Active and Simple Catalyst for Cyanosilylation of Aldehydes and Ketones (2005)

LiCl acts as a highly effective catalyst for cyanosilylation of various aldehydes and ketones to the corresponding silylated cyanohydrins. The reaction proceeds smoothly with a substrate/catalyst molar ratio of 100-100,000 at 20-25 degrees C under solvent-free conditions. alpha,beta-Unsaturated aldehydes are completely converted to the 1,2-adducts. The cyanation products can be isolated by direct distillation of the reaction mixture.
개질 CaO계와 CSA계 팽창재를 혼합사용한 콘크리트의 건조수축 및 균열복구 성능평가에 관한 연구 (2016)

콘크리트 건축물에서의 균열은 건축물의 안전성을 확보하기 위한 가장 기초적인 고려사항이다. 본 연구에서는 콘크리트 건축물의 콘크리트 타설초기 발생하는 건조수축에 의한 균열의 발생을 억제하고 이미 발생된 균열을 스스로 치유할 수 있는 콘크리트 배합을 제시하고자 하였다. 이를 위하여 개질 CaO와 CSA계 팽창재를 혼합한 모르타르 배합을 제시하고 이에 대한...
Direct synthesis of HZSM-5 from natural clay (2014)

Highly crystalline HZSM-5 zeolite was directly synthesized through a steam-assisted conversion (SAC) approach using layered kaolin as the raw material and NH<sub>3</sub>·H<sub>2</sub>O as an alkaline vapor source.
Molecular properties of lamprey fibrinogen. (1981)

Application of conventional methods not previously used for preparing lamprey fibrinogen has yielded preparations of very high purity and stability. These preparations made possible a detailed evaluation of molecular weights in normal and chaotropic buffers. The native molecule repeatedly gave a molecular weight of 352,000 to 358,000 via sedimentation equilibrium in citrate buffer; a molecular weight of 354,500 was obtained in guanidine buffer. An anomalous increase of the value of the measured apparent partial specific volume was observed in guanidine buffer. Molecular weight data of the reduced and alkylated subunits of lamprey fibrinogen, obtained by four different methods, have led us to assign molecular weights of 110,000 for (A)alpha, 72,000 for (B) beta, and 50,000 for gamma. Based upon these molecular weights obtained for the subunits, as well as that of the native fibrinogen molecule, the subunit composition can best be fitted to the formulation [(A)n alpha, (B) beta 2, gamma 2] rather than the conventional[(A) alpha 2, (B) beta 2, gamma 2] which would yield a molecular weight of 464,000. Analysis of a stabilized clot induced by Ca2+ showed only gamma dimers; alpha subunit polymerization was undetectable. Cross-linking of lamprey fibrin in the presence of dansylcadaverine and Ca2+ results in fluorescent labeling of the gamma chains and to a lesser extent the gamma dimer. Differing from other reported vertebrate cross-linking systems, the lamprey fibrin alpha subunit appears essentially unreactive in both polymer formation and dansylcadaverine incorporation. These distinct molecular properties may be reasonably attributed to the existence of the single (A)n alpha subunit in the molecular structure of the molecule.
Implementation of heuristic search strategies for distribution feeder reconfiguration (1990)

A method for feeder reconfiguration with the potential for handling realistic operating constraints is presented. The approach taken is to set up a decision tree to represent the various switching operations available. A best-first tree searching strategy, based on heuristics, is used to evaluate the various alternatives. Switching options which could result in overloads, voltage problems, or other operating constraints, such as those associated with system protection, are quickly eliminated as possibilities. The development of a rule-based system aimed at the reduction of the search space is presented as a means of implementing the above strategy. An example is used to illustrate the concepts described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Glyoxal Acetals (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlyoxal AcetalsO. C. Dermer and James P. YukCite this: J. Am. Chem. Soc. 1955, 77, 5, 1285–1286Publication Date (Print):March 1, 1955Publication History Published online1 May 2002Published inissue 1 March 1955https://pubs.acs.org/doi/10.1021/ja01610a060https://doi.org/10.1021/ja01610a060research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integrated Display System for Low Visibility Landing and Surface Operations (1998)

This report summarizes the software products and system architectures developed by Lockheed Martin in support of the Low Visibility Landing and Surface Operations (LVLASO) program at NASA Langley Research Center. It presents an overview of the technical aspects, capabilities, and system integration issues associated with an integrated display system (IDS) that collects, processes and presents information to an aircraft flight crew during all phases of landing, roll-out, turn-off, inbound taxi, outbound taxi and takeoff. Communications hardware, drivers, and software provide continuous real-time data at varying rates and from many different sources to the display programs for presentation on a head-down display (HDD) and/or a head-up display (HUD). An electronic moving map of the airport surface is implemented on the HDD which includes the taxi route assigned by air traffic control, a text messaging system, and surface traffic and runway status information. Typical HUD symbology for navigation and control of the aircraft is augmented to provide aircraft deceleration guidance after touchdown to a pilot selected exit and taxi guidance along the route assigned by ATC. HUD displays include scene-linked symbolic runways, runway exits and taxiways that are conformal with the actual locations on the airport surface. Display formats, system architectures, and the various IDS programs are discussed.
Cells and viruses with mutations affecting viral entry are selected during persistent infections of L cells with mammalian reoviruses (1993)

Previous studies demonstrated that both cellular and viral mutants are selected during maintenance of persistent infections established in murine L cells with high-passage stocks of mammalian reoviruses. In particular, when one culture was cured of persistent infection, the resulting cells were found to support the growth of viruses isolated from persistently infected cultures (termed PI viruses here) better than that of wild-type (wt) viruses (R. Ahmed, W. M. Canning, R. S. Kauffman, A. H. Sharpe, J. V. Hallum, and B. N. Fields, Cell 25:325-332, 1981). To address the nature of cellular and viral mutations selected during maintenance of persistent reovirus infections, we established independent, persistently infected cultures with L cells and high-passage stocks of wt reovirus. These cultures served as sources of new PI viruses and cured cells for study. We found that although wt viruses grew poorly in cured cells when infection was initiated with intact virions, they grew well in cured cells when infection was initiated with infectious subvirion particles generated from virions by in vitro treatment with chymotrypsin. This finding indicates that the block to growth of wt viruses in cured cells involves an early step that is unique to infection by virions, such as proteolytic processing in an endocytic compartment. We also found that PI viruses grew better than wt viruses in L cells treated with ammonium chloride, a weak base that inhibits the pH decrease in endosomes and lysosomes. Because ammonium chloride blocks an early step in infection by intact virions, probably the proteolytic processing of viral outer capsid proteins by acid-dependent cellular proteases in late endosomes or lysosomes, this finding indicates that PI viruses differ from wt viruses with respect to viral entry into cells. Therefore, these results indicate that both cells and viruses evolve mutations that affect one or more early steps in the viral growth cycle during maintenance of L-cell cultures persistently infected with reoviruses.
Nucleoprotein of influenza A virus negatively impacts antiapoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication (2015)

Apoptosis of host cells profoundly influences virus propagation and dissemination, events that are integral to influenza A virus (IAV) pathogenesis. The trigger for activation of apoptosis is regulated by an intricate interplay between cellular and viral proteins, with a strong bearing on IAV replication. Though the knowledge of viral proteins and mechanisms employed by IAV to induce apoptosis has advanced considerably of late, we know relatively little about the repertoire of host factors targeted by viral proteins. Thus, identification of cellular proteins that are hijacked by the virus will help us not only to understand the molecular underpinnings of IAV-induced apoptosis, but also to design future antiviral therapies. Here we show that the nucleoprotein (NP) of IAV directly interacts with and suppresses the expression of API5, a host antiapoptotic protein that antagonizes E2F1-dependent apoptosis. siRNA-mediated depletion of API5, in NP-overexpressed as well as IAV-infected cells, leads to upregulation of apoptotic protease activating factor 1 (APAF1), a downstream modulator of E2F1-mediated apoptosis, and cleavage of caspases 9 and 3, although a reciprocal pattern of these events was observed on ectopic overexpression of API5. In concordance with these observations, annexin V and 7AAD staining assays exhibit downregulation of early and late apoptosis in IAV-infected or NP-transfected cells on overexpression of API5. Most significantly, while overexpression of API5 decreases viral titers, cellular NP protein as well as mRNA levels in IAV-infected A549 cells, silencing of API5 expression causes a steep rise in the same parameters. From the data reported in this manuscript, we propose a proapoptotic role for NP in IAV pathogenesis, whereby it suppresses expression of antiapoptotic factor API5, thus potentiating the E2F1-dependent apoptotic pathway and ensuring viral replication.
Synchrotron Big Data Science (2018)

The rapid development of synchrotrons has massively increased the speed at which experiments can be performed, while new techniques have increased the amount of raw data collected during each experiment. While this has created enormous new opportunities, it has also created tremendous challenges for national facilities and users. With the huge increase in data volume, the manual analysis of data is no longer possible. As a result, only a fraction of the data collected during the time- and money-expensive synchrotron beam-time is analyzed and used to deliver new science. Additionally, the lack of an appropriate data analysis environment limits the realization of experiments that generate a large amount of data in a very short period of time. The current lack of automated data analysis pipelines prevents the fine-tuning of beam-time experiments, further reducing their potential usage. These effects, collectively known as the "data deluge," affect synchrotrons in several different ways including fast data collection, available local storage, data management systems, and curation of the data. This review highlights the Big Data strategies adopted nowadays at synchrotrons, documenting this novel and promising hybridization between science and technology, which promise a dramatic increase in the number of scientific discoveries.
Prevalence of O25b-ST131 clone among<i>Escherichia coli</i>strains producing CTX-M-15, CTX-M-14 and CTX-M-92 β-lactamases (2016)

This study demonstrates the predominance of the ST131 clone among CTX-M β-lactamase-producing E. coli isolates. Dissemination of bla<sub>CTX-M</sub> genes in ST131 strains can be linked not only to highly adapted IncF plasmids such as FII/FIB and FII, but also to plasmid replicon types A/C, L/M and HI1.
Phenomenology of current-induced spin-orbit torques (2013)

Currents induce magnetization torques via spin-transfer when the spin angular momentum is conserved or via relativistic spin-orbit coupling. Beyond simple models, the relationship between material properties and spin-orbit torques is not known. Here, we present a novel phenomenology of current-induced torques that is valid for any strength of intrinsic spin-orbit coupling. In ${\mathrm{Pt}|\mathrm{Co}|\mathrm{AlO}}_{x}$, we demonstrate that the domain walls move in response to a novel relativistic dissipative torque that is dependent on the domain wall structure and that can be controlled via the Dzyaloshinskii-Moriya interaction. Unlike the nonrelativistic spin-transfer torque, the new torque can, together with the spin-Hall effect in the Pt layer, move domain walls by means of electric currents parallel to the walls.
A high performance sense amplifier for a 5 V dynamic RAM (1980)

Increasing dynamic RAM cell density and the use of a single low-voltage power supply have made it mandatory to store the full power supply voltage in the cell and to be able to detect smaller signals reliably with the initial sense amplifier. The authors present a circuit design approach that restores the cell to a full V/SUB DD/ `1' level, preamplifies the initial charge imbalance before sensing by conventional techniques, and is used in the Fairchild 64K design. Design requirements and a detailed analysis of the amplifier are presented along with simulated results, followed by performance data. The circuit analysis shows how the key design parameters should be chosen and the effects of clock timing variations on the performance of the sense amplifier.
Colorectal Cancer Therapy Using a <i>Pediococcus pentosaceus</i> SL4 Drug Delivery System Secreting Lactic Acid Bacteria-Derived Protein p8. (2019)

Despite decades of research into colorectal cancer (CRC), there is an ongoing need for treatments that are more effective and safer than those currently available. Lactic acid bacteria (LAB) show beneficial effects in the context of several diseases, including CRC, and are generally regarded as safe. Here, we isolated a <i>Lactobacillus rhamnosus</i> (LR)-derived therapeutic protein, p8, which suppressed CRC proliferation. We found that p8 translocated specifically to the cytosol of DLD-1 cells. Moreover, p8 down-regulated expression of Cyclin B1 and Cdk1, both of which are required for cell cycle progression. We confirmed that p8 exerted strong anti-proliferative activity in a mouse CRC xenograft model. Intraperitoneal injection of recombinant p8 (r-p8) led to a significant reduction (up to 59%) in tumor mass when compared with controls. In recent years, bacterial drug delivery systems (DDSs) have proven to be effective therapeutic agents for acute colitis. Therefore, we aimed to use such systems, particularly LAB, to generate the valuable therapeutic proteins to treat CRC. To this end, we developed a gene expression cassette capable of inducing secretion of large amounts of p8 protein from <i>Pediococcus pentosaceus</i> SL4 (PP). We then confirmed that this protein (PP-p8) exerted anti-proliferative activity in a mouse CRC xenograft model. Oral administration of PP-p8 DDS led to a marked reduction in tumor mass (up to 64%) compared with controls. The PP-p8 DDS using LAB described herein has advantages over other therapeutics; these advantages include improved safety (the protein is a probiotic), cost-free purification, and specific targeting of CRC cells.
Rheological blends for drug delivery. II. Prolongation of nerve blockade, biocompatibility, and <i>in vitro–in vivo</i> correlations (2009)

Rheological polymer blends of hyaluronic acid (HA) and hydroxypropylmethyl cellulose (HPMC) were evaluated as prolonged duration delivery vehicles for local anesthetics using a rat sciatic nerve blockade model. HA-HPMC blends extended the duration of sensory block approximately threefold compared to that achieved using a bupivacaine solution. Blending HA and HPMC facilitated the injection of higher polymer concentration delivery vehicles and reduced the rate of polymer hydration compared to HA solutions, enabling prolonged drug release. The duration of effective nerve block was correlated with each of the zero shear viscosity, polymer concentration, yield stress, and gel point frequency of the blends, while a two-parameter model correlating duration of nerve block with zero shear viscosity and humectancy provided improved fits to the in vivo data compared to any single variable alone. The blends exhibited no cytotoxicity and induced only a mild short-term inflammatory reaction in vivo at the site of injection, with all blends largely resorbed 4 days postinjection.
On the efficiency of insertion of aluminium into the framework of Y-type zeolite by the hydrothermal process of Liu, Klinowski, and Thomas (1987)

Liu et al.'s procedure for completely reversing the ultrastabilization of Y-type zeolite was applied to a sample of high quality, commercially prepared ultrastable Y-zeolite (USY); a combination of characterization techniques showed that significant framework realumination occurred, but that the product was only 80% crystalline.
Ch-ch-ch-ch-changes... (2002)

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Jim Smith Editor in Chief



I was delighted when the Company of Biologists asked me to take over from Chris Wylie as Editor in Chief of Development . At least, I think I was. Any doubt on this matter does not derive from uncertainty about the journal, or about the honour that
A Comparative Investigation on Multiwalled Carbon Nanotubes and Carbon Black as Conducting Additive in LiNi[sub 0.7]Co[sub 0.3]O[sub 2] (2006)

A comparative investigation was carried out on multiwalled carbon nanotubes (MWCNTs) and carbon black as a conducting additive in for lithium ion batteries. All particles were connected together by well-crystallized MWCNTs to form a conductive network wiring. The discharge capacities of the composite cathode were improved to be with 89.9% efficiency at the rate and at the 1C rate in the initial cycle when carbon black was replaced by MWCNTs. The results proved that MWCNTs wrapping was an effective way to improve electron conducting and reversible capacity with high cycle efficiency of cathode materials.
Wavelet-based resource allocation in ATM networks (2002)

In recent years, numerous publications have identified a high number of traffic sources to be of self-similar nature. Such traffic can have a negative impact on traditional queuing systems. This paper presents a call admission control algorithm that uses periodic wavelet analysis applied to traffic measurements to estimate the amount of resources necessary to support a certain set of connections under quality-of-service constraints. This algorithm even exploits correlated traffic. Extensive simulation results illustrate the performance of the algorithm over a large parameter spectrum (Hurst parameter, load, and intensity), and the results consistently show that the higher the Hurst parameter, the higher the statistical gain.