gebhart/patrepeval huggingface dataset:
Roles of proteasomes, transporter for antigen presentation (TAP), and β 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway (1996)

Latex-OVA and bacteria expressing an OVA fusion protein were processed by macrophages via an alternate class I MHC (MHC-I) processing pathway to present OVA(257-264):Kb. This pathway was resistant to dipeptide aldehyde proteasome inhibitors and brefeldin A, unlike the cytosolic MHC-I pathway. TAP1-/- macrophages exhibited decreases in cell surface peptide-receptive MHC-I and binding of extracellular peptide during transient incubations. This may explain an apparent influence of TAP on alternate MHC-I processing. Alternate MHC-I processing by TAP1-/- cells was enhanced by preincubation at 26 degrees C or with beta 2-microglobulin to increase peptide-receptive MHC-I. Thus, peptides may bind to MHC-I within post-Golgi vacuolar organelles accessible to exogenous beta 2-microglobulin or on the cell surface (following peptide regurgitation).
Stereoselective Transformation of Enantiopure Cyclohexenol into <i>cis</i>-Hydrindan. An Enantioselective Formal Total Synthetic Route to (+)-Pumiliotoxin C (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTStereoselective Transformation of Enantiopure Cyclohexenol into cis-Hydrindan. An Enantioselective Formal Total Synthetic Route to (+)-Pumiliotoxin CMasahiro Toyota, Takanobu Asoh, Masaki Matsuura, and Keiichiro FukumotoView Author Information Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-77, Japan Cite this: J. Org. Chem. 1996, 61, 24, 8687–8691Publication Date (Web):November 29, 1996Publication History Received10 July 1996Published online29 November 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo9613085https://doi.org/10.1021/jo9613085brief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views1405Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Chemical synthesis,Cyclization,Organic compounds,Organic synthesis Get e-Alerts
Les "anatomies" d'André Vésale (2006)

http://www.biusante.parisdescartes.fr/histmed/medica/vesale.htm, 2006
Modified polyether-sulfone membrane: a mini review (2017)

Polyethersulfone has been widely used as a promising material in medical applications and waste-treatment membranes since it provides excellent mechanical and thermal properties. Hydrophobicity of polyethersulfone is considered one main disadvantage of using this material because hydrophobic surface causes biofouling effects to the membrane which is always thought to be a serious limitation to the use of polyethersulfone in membrane technology. Chemical modification to the material is a promising solution to this problem. More specifically surface modification is an excellent technique to introduce hydrophilic properties and functional groups to the polyethersulfone membrane surface. This review covers chemical modifications of the polyethersulfone and covers different methods used to enhance the hydrophilicity of polyethersulfone membrane. In particular, the addition of amino functional groups to polyethersulfone is used as a fundamental method either to introduce hydrophilic properties or introduce nanomaterials to the surface of polyethersulfone membrane. This work reviews also previous research reports explored the use of amino functionalized polyethersulfone with different nanomaterials to induce biological activity and reduce fouling effects of the fabricated membrane.
Expression of stress proteins heme oxygenase‐1 and ‐2 in acute pancreatitis and pancreatic islet βTC3 and acinar AR42J cells (1997)

Oxygen-derived free radicals have been implicated in the pathogenesis of acute pancreatitis, yet adaptive responses in the pancreas in vivo to oxidative stress remain poorly defined. We have investigated expression of the stress protein heme oxygenase in the intact pancreas of rats with caerulein-induced pancreatitis and in cultured pancreatic acinar and islet cell lines. Expression of inducible heme oxygenase-1 (HO-1) in the pancreas in vivo was enhanced 12-24 h after induction of pancreatitis. In murine islet (betaTC3) and rat acinar (AR42J) pancreatic cells, H2O2, methyl viologen, cadmium chloride and diethylmaleate enhanced HO-1 expression in a dose- and time-dependent manner, without altering expression of constitutive HO-2. Enhanced expression of HO-1 in the pancreas in vivo and pancreatic islet and acinar cells may contribute to cellular defences against oxidative stress associated with acute pancreatitis.
Antitumor effects of electrochemical treatment. (2013)

Electrochemical treatment is an alternative modality for tumor treatment based on the application of a low intensity direct electric current to the tumor tissue through two or more platinum electrodes placed within the tumor zone or in the surrounding areas. This treatment is noted for its great effectiveness, minimal invasiveness and local effect. Several studies have been conducted worldwide to evaluate the antitumoral effect of this therapy. In all these studies a variety of biochemical and physiological responses of tumors to the applied treatment have been obtained. By this reason, researchers have suggested various mechanisms to explain how direct electric current destroys tumor cells. Although, it is generally accepted this treatment induces electrolysis, electroosmosis and electroporation in tumoral tissues. However, action mechanism of this alternative modality on the tumor tissue is not well understood. Although the principle of Electrochemical treatment is simple, a standardized method is not yet available. The mechanism by which Electrochemical treatment affects tumor growth and survival may represent more complex process. The present work analyzes the latest and most important research done on the electrochemical treatment of tumors. We conclude with our point of view about the destruction mechanism features of this alternative therapy. Also, we suggest some mechanisms and strategies from the thermodynamic point of view for this therapy. In the area of Electrochemical treatment of cancer this tool has been exploited very little and much work remains to be done. Electrochemical treatment constitutes a good therapeutic option for patients that have failed the conventional oncology methods.
Identification of Crucial Hydrogen-Bonding Residues for the Interaction of Herpes Simplex Virus DNA Polymerase Subunits via Peptide Display, Mutational, and Calorimetric Approaches (2001)

The catalytic subunit, Pol, of herpes simplex virus DNA polymerase interacts via its extreme C terminus with the processivity subunit, UL42. This interaction is critical for viral replication and thus a potential target for antiviral drug action. To investigate the Pol-binding region on UL42, we engineered UL42 mutations but also used random peptide display to identify artificial ligands of the Pol C terminus. The latter approach selected ligands with homology to residues 171 to 176 of UL42. Substitution of glutamine 171 with alanine greatly impaired binding to Pol and stimulation of long-chain DNA synthesis by Pol, identifying this residue as crucial for subunit interactions. To study these interactions quantitatively, we used isothermal titration calorimetry and wild-type and mutant forms of Pol-derived peptides and UL42. Each of three peptides corresponding to either the last 36, 27, or 18 residues of Pol bound specifically to UL42 in a 1:1 complex with a dissociation constant of 1 to 2 microM. Thus, the last 18 residues suffice for most of the binding energy, which was due mainly to a change in enthalpy. Substitutions at positions corresponding to Pol residue 1228 or 1229 or at UL42 residue 171 abolished or greatly reduced binding. These residues participate in hydrogen bonds observed in the crystal structure of the C terminus of Pol bound to UL42. Thus, interruption of these few bonds is sufficient to disrupt the interaction, suggesting that small molecules targeting the relevant side chains could interfere with Pol-UL42 binding.
A study of replacement algorithms for a virtual-storage computer (1966)

One of the basic limitations of a digital computer is the size of its available memory. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> In most cases, it is neither feasible nor economical for a user to insist that every problem program fit into memory. The number of words of information in a program often exceeds the number of cells (i.e., word locations) in memory. The only way to solve this problem is to assign more than one program word to a cell. Since a cell can hold only one word at a time, extra words assigned to the cell must be held in external storage. Conventionally, overlay techniques are employed to exchange memory words and external-storage words whenever needed; this, of course, places an additional planning and coding burden on the programmer. For several reasons, it would be advantageous to rid the programmer of this function by providing him with a “virtual” memory larger than his program. An approach that permits him to use a sufficiently large address range can accomplish this objective, assuming that means are provided for automatic execution of the memory-overlay functions.
Learning One More Thing (1994)

Most research on machine learning has focused on scenarios in which a learner faces a single, isolated learning task. The lifelong learning framework assumes instead that the learner encounters a multitude of related learning tasks over its lifetime, providing the opportunity for the transfer of knowledge. This paper studies lifelong learning in the context of binary classification. It presents the invariance approach, in which knowledge is transferred via a learned model of the invariances of the domain. Results on learning to recognize objects from color images demonstrate superior generalization capabilities if invariances are learned and used to bias subsequent learning.
RTP Payload Format for Uncompressed Video (2005)

This memo specifies a packetization scheme for encapsulating uncompressed video into a payload format for the Real-time Transport Protocol, RTP.It supports a range of standard-and high-definition video formats, including common television formats such as ITU BT.601, and standards from the Society of Motion Picture and Television Engineers (SMPTE), such as SMPTE 274M and SMPTE 296M.The format is designed to be applicable and extensible to new video formats as they are developed.
Notes- Reaction of Chloromethyl Ether with Primary Amines. (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes- Reaction of Chloromethyl Ether with Primary Amines.Henri Ulrich and Joseph RubinfeldCite this: J. Org. Chem. 1961, 26, 5, 1637–1638Publication Date (Print):May 1, 1961Publication History Published online26 February 2003Published inissue 1 May 1961https://doi.org/10.1021/jo01064a606Request reuse permissionsArticle Views225Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (266 KB) Get e-Alertsclose Get e-Alerts
Sequence of the Citrobacter freundii OS60 chromosomal ampC beta-lactamase gene (1986)

The Citrobacter freundii OS60 ampC beta-lactamase gene was sequenced and found to encode a 380-amino-acid-long precursor with a 19-residue signal peptide. The mature protein has a predicted molecular mass of 39781 Da. The first 60 residues of the purified enzyme, as determined by sequential Edman degradation, are identical to the amino acid sequence inferred from the gene sequence. Also, the amino acid composition determined for the purified beta-lactamase and that given by the gene sequence are in good agreement. 77% of the amino acid positions hold identical residues in the C. freundii and Escherichia coli K12 chromosomal AmpC beta-lactamases. This clearly puts the C. freundii enzyme into the class C of beta-lactamases. Of the 68 amino-terminal residues determined for the Enterobacter cloacae P99 beta-lactamase, 44 are identical to the corresponding residues of the C. freundii enzyme. All three enzymes, as well as that of Pseudomonas aeruginosa 18S/H are highly similar around the active-site serine at position 64 of the mature protein.
Integration of Drones into Domestic Airspace: Selected Legal Issues (2013)

This report describes the regulatory framework for permitting the use of unmanned vehicles and the potential rulemaking that will occur over the next few years. It also discusses theories of takings and property torts as they relate to drone flights over or near private property and the privacy interests implicated by drone surveillance conducted by private actors and the potential countervailing First Amendment rights to gather and receive news. Finally, this report explores possible congressional responses to these privacy concerns, discusses how the FAA has approached these concerns, and identifies additional potential legal issues.
Whistler instability in the Elmo Bumpy Torus (1982)

A governing equation for whistler modes in the Elmo Bumpy Torus is presented and solved perturbatively. To lowest order, a discrete spectrum of real frequencies is determined. Finite growth rates are found to first order. Attention is focused on trapped electron resonances. In the frequency range of interest, the destabilizing terms involve summations over a large number of resonances. A threshold condition is obtained, and typical growth rates, corresponding to plausible machine parameters, are presented.
Measurement method for PV modules based on DC-DC converters with microcontroller (2009)

This paper proposes a versatile system to test and measure systematically the real evolution for the I-V characteristic curves of photovoltaic (PV) modules or arrays. The system employs a novel circuit solution based on DC-DC converters that shows several advantages with regard to classical methods: simple structure, scalability, fast response and low cost. The measure of the desired characteristics of photovoltaic modules includes high speed of response and high fidelity. The prototype is governed by a microcontroller and experimental results show the usefulness of the proposed system. Moreover, a user environment has been developed in order to control the overall system from a computer.
A Facile and Convenient Synthetic Method for Fluorine-containing 1H-Pyrrolo[3,2-h]quinolines (2000)

Aromatic nucleophilic nitrogen-nitrogen exchange reaction of N,Ndimethyl-5,7-bis(trifluoroacetyl)-8-quinolylamine (1) with some amino acid derivatives gave the corresponding N-[5,7-bis(trifluoroacetyl)-8-quinolyl]amino acid derivatives (2) in excellent yields.Base-catalyzed cyclization of 2 afforded fluorine-containing 1H-pyrrolo[3,2-h]quinolines (3, 4) in high yields.In recent years much attention has been focused on the development of new methodologies for the syntheses of many kinds of fluorine-containing heterocycles, since these compounds are now widely
Functional Effect of the <i> p22 <sup>phox</sup> </i> −930 <sup>A/G</sup> Polymorphism on p22 <sup>phox</sup> Expression and NADPH Oxidase Activity in Hypertension (2004)

Oxidative stress induced by superoxide is implicated in hypertension. NADPH oxidase is the main source of superoxide in phagocytic and vascular cells, and the p22phox subunit is involved in NADPH oxidase activation. Recently we reported an association of -930A/G polymorphism in the human p22phox gene promoter with hypertension. This study was designed to investigate the functional role of this polymorphism in hypertension. We thus investigated the relationships between the -930A/G polymorphism and p22phox expression and NADPH oxidase-mediated superoxide production in phagocytic cells from 70 patients with essential hypertension and 70 normotensive controls. Genotyping of the polymorphism was performed by restriction fragment length polymorphism. NADPH oxidase activity was determined by chemiluminescence assays, and p22phox mRNA and protein expression was measured by Northern and Western blotting, respectively. Compared with hypertensive subjects with the AA/AG genotype, hypertensive subjects with the GG genotype exhibited increased (P<0.05) phagocytic p22phox mRNA (1.26+/-0.06 arbitrary unit [AU] versus 0.99+/-0.03 AU) and protein levels (0.58+/-0.05 AU versus 0.34+/-0.04 AU) and enhanced NADPH oxidase activity (1998+/-181 counts/s versus 1322+/-112 counts/s). No differences in these parameters were observed among genotypes in normotensive cells. Transfection experiments on vascular smooth muscle cells showed that the A-to-G substitution of this polymorphism produced an increased reporter gene expression in hypertensive cells. Nitric oxide production, as assessed by measurement of serum nitric oxide metabolites, was lower in GG hypertensive subjects than in AA/AG hypertensive subjects. In conclusion, these results suggest that hypertensive subjects carrying the GG genotype of the p22phox -930A/G polymorphism are highly exposed to NADPH oxidase-mediated oxidative stress.
Throughput analysis and design of fixed and adaptive ARQ/diversity systems for slow fading channels (2002)

We study the performance of a fixed diversity (FD) ARQ system in which no error correction coding is used, and only second order transmitter diversity is used. In the system two spatially separated antennas are used to transmit the same information signal in a staggered fashion. In an FD system with two transmitting antennas, due to the staggered nature of transmission, the information rate of the FD system is 1/2, and we compare this system with the block-coded hybrid ARQ system of rate 1/2 used by Sayeed (see International Journal of Wireless Information Networks, 1997, Doctoral Disseration, University of Pennsylvania, 1996), and by Weerackody (1993). Due to the lower information rate of the transmitter diversity system, we do not wish to diversify at all times, but only when diversity is required. Thus we propose an adaptive ARQ/diversity (AD) system, in which the transmitter adaptively switches between the single antenna and dual antenna mode using the implicit channel state information contained in the number of consecutive ACKs and NACKs. Using analytical techniques we show that the performance of the adaptive diversity system equals the performance of adaptive ARQ/FEC techniques that have been used by Kallel (1994), by Sayeed and Weerackody (see Proceedings of Conference on Information Sciences and Systems, CISS '96, 1996), and by Deng and Lin (see IEEE Transactions on Communications, vol.-43, no.2/3/4, p.733-7, 1995) which uses the uncoded and a rate half maximum distance separable code (MDS).
Immigration Law and Institutional Design (2013)

Symposium Introduction - There are few more sprawling and unruly areas of academic inquiry than the law of immigration policy in the United States and around the world. Three reasons readily come to mind for explaining the inherent difficulties in this area.
Uniform lifetime prolongation of a high density plasma channel left in the wake of femtosecond filament (2017)

We demonstrate uniform lifetime prolongation of an entire plasma filament generated by a high-power femtosecond laser pulse. The entire filament is irradiated by a secondary nano-second laser pulse that co-propagates with the femtosecond laser. The plasma filament partially absorbs the nanosecond laser radiation, and plasma lifetime is extended along the entire channel resulting in a smooth and continuous high-density plasma column with lifetime longer than 30 ns. We present an experimental and theoretical study of the intensity range of the secondary laser required for effective lifetime prolongation and the behavior of the plasma density at the onset of breakdown triggered by the secondary laser. Our study shows that an efficient prolongation of the lifetime of plasma filament occurs in the intensity range of 0.03–0.3 TW/cm2.
A 5GHz resistive-feedback CMOS LNA for low-cost multi-standard applications (2006)

A 5GHz broadband LNA achieves 25dB gain, 2dB NF, -14dBm IIP3 and -13dB S11 while drawing 15.5mA from a 2.7V supply. The circuit is fabricated in an RF-enhanced 90nm CMOS technology. The active die area is 0.025mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup>
The influence of lining techniques on the marginal seal of Class II composite resin restorations. (1993)

Various sealing techniques using a light-curing dental adhesive (Scotchbond 2) and bulk application of a light-curing resin-bonded ceramic were examined in 203 Class II cavities. Different pretreatment procedures and lining materials were used, and in one series resin impregnation of the contraction gap was included. The presence of gaps or leakage was disclosed either by a dye or a fluorescent resin penetration technique. In many restorations, Scotchbond 2 and a light-curing glass-ionomer lining did not prevent gap formation at the cervical wall. The gap usually occurred between the liner and the dentin, with dye penetration into the dentin. Three liners, one containing polytrifluorethylene sodium fluoride and calcium fluoride, one containing polyamide resin, and one containing calcium hydroxide, did not prevent dye penetration to the dentin at all; good dentinal protection was frequently observed, however, in cavities treated with a hydrophilic shellac film prior to placement of a polystyrene liner. The best results were observed when dentinal treatment with this lining system was followed by resin impregnation of the contraction gap after the composite resin had set.
Hexavalent chromium induced tunable surface functionalization of graphite (2016)

Graphite with the oxygen related functional groups was achieved by functionalized with hexavalent chromium in certain conditions.