gebhart/patrepeval huggingface dataset:
Short-term travel behavior prediction with GPS, land use, and point of interest data (2018)

In everyday travel, U.S. commuters will each spend 38 h a year stuck in traffic and waste over $800 in fuel (TTI, 2015). Yet, despite this statistic, the regular commute of drivers is often predictable, leading many federal projects to aim at alleviating congestion through traveler information and intelligent transportation systems (e.g., INFLO, Queue WARN, CACC, EnableATIS, ATIS2.0). Short-term destination prediction is a developing field of research that can improve these approaches through real-traveler information, such as route, traffic incidence, and congestion levels. The short-term destination prediction problem consists of capturing vehicle Global Positioning System (GPS) traces and learning from historic locations and trajectories to predict a vehicle's destination. Drivers have predictable trip destinations that can be estimated through probabilistic modeling of past trips. To study these concepts, a database of GPS driving traces (260 participants for 70 days) was collected. To model the user's trip purpose in the prediction algorithm, a new data source was explored: point of interest (POI)/land use data. An open source land use/POI dataset is merged with the GPS dataset. The resulting database includes over 20,000 trips with travel characteristics and land use/POI data. From land use/POI data and travel patterns, trip purpose was calculated with machine learning methods. To take advantage of this data source, a new prediction model structure was developed that uses trip purpose when it is available and that falls back on traditional spatial temporal Markov models when it is not. For the first time, there is an understanding of “why” a trip is taken (not just “where” and “when”), allowing the use of “why” in the prediction model. This paper explores the baseline model followed by the inclusion of trip purpose. First, a baseline tiered time origin model was developed using the Markov Chain approach. This modelling structure allows for a short training period of current modeling techniques. The other major advantage to this structure is it allows for easy implementation of the trip purpose module. Then, a machine learning technique derived the trip purpose on 5-, 15- and 30-trip learning sets, followed by results organized by purpose, time, and origin. The machine learning technique does not require future land use data and is feasible for applicable use. This model is the first to use trip purpose to make a short-term destination prediction in pseudo real-time. Results show improved accuracy and speed over the current start-of-trip destination prediction models.
Fast configurable polynomial division for error control coding applications (2002)

The motivation for this paper is the need for high levels of reliability in modern telecommunication systems requiring very high data transmission rates. The search for technologically independent solutions, easy to implement on low cost and popular devices such as FPGA is an important issue. In this paper, we present a method to improve effectively the speed performance of the polynomial division performed in most error detecting and error correcting circuits. It is based on a pipeline structure for the polynomial division. Furthermore, the proposed solution is fully configurable, both from the static and the dynamic points of view. At synthesis stage, the parallelism level (size of the pipeline structure) and the maximal size of the polynomial divisor must both be chosen. Afterwards, the actual divisor can be chosen and changed while the circuit is running. The architecture proved to be very effective, as data rates up to 2.5 Gbits/s have been reached.
Graft-<b><i>versus</i></b>-Tax Response in Adult T-Cell Leukemia Patients after Hematopoietic Stem Cell Transplantation (2004)

Adult T-cell leukemia (ATL) caused by human T-cell leukemia virus type I (HTLV-I) is characterized by poor prognosis after chemotherapy. Recent clinical trials have indicated, however, that allogeneic but not autologous hematopoietic stem cell transplantation (HSCT) for ATL can yield better clinical outcomes. In the present study, we investigated cellular immune responses of ATL patients who obtained complete remission after nonmyeloablative allogeneic peripheral blood HSCT from HLA-identical sibling donors. In the culture of peripheral blood mononuclear cells (PBMCs) from a post-HSCT but not pre-HSCT ATL patient, CD8(+) CTLs proliferated vigorously in response to stimulation with autologous HTLV-I-infected T cells that had been established before HSCT in vitro. These CTLs contained a large number of monospecific CTL population directed to a HLA-A2-restricted HTLV-I Tax 11-19 epitope. The frequency of Tax 11-19-specific CD8+ CTLs in this patient markedly increased also in vivo after HSCT, as determined by staining with HLA-A2/Tax 11-19 tetramers. Similar clonal expansion of HTLV-I Tax-specific CTLs exclusively directed to a HLA-A24-restricted Tax 301-309 epitope was observed in the PBMCs from another ATL patient after HSCT from a HTLV-I-negative donor. Among four post-HSCT ATL patients tested, HTLV-I-specific CTLs were induced in the PBMC culture from three patients but not from the remaining one who had later recurrence of ATL. These observations suggested that reconstituted immunity against antigen presentation in ATL patients after HSCT resulted in strong and selective graft-versus-HTLV-I response, which might contribute to graft-versus-leukemia effects.
Structural alterations in the Bacillus subtilis Spo0A regulatory protein which suppress mutations at several spo0 loci (1990)

Secondary site mutations that restore sporulation to sporulation-defective spo0F or spo0B deletion mutants were found to reside in the spo0A gene. Sequence analysis of 23 such sof mutants showed that the sof mutations fell into six classes of missense codon changes, primarily in the conserved amino-terminal domain of the response regulator Spo0A protein. Changes were observed in codons 12, 14, 60, 92, and 121. The residues affected were predominantly located in the potential turn regions at one end of the amino-terminal conserved domain on the same topological face as the active site aspartate residues. The ability of sof mutations to suppress deficiencies in the transmitter kinases, KinA and KinB, of two-component regulatory systems was tested. All of the sof mutations suppressed the sporulation deficiency of kinA mutants but only two classes among five tested suppressed kinB mutations. sof mutants segregated Spo- colonies at high frequency. Five of these Spo- mutants were found to result from mutations in the spo0A locus that reversed the effect of the sof mutatation. One of these was sequenced and found to have the original sof mutation and a new mutation, sos, at codon 105. The accumulation of sos mutations in sof strains suggested that the sof mutations have a subtle, yet deleterious, effect on the growth of the cell. The results suggested that the sof mutations increase the avidity for or reactivity with transmitter kinases in an allele-specific manner, although in some cases it is possible that the sof mutations obviate the need for phosphorylation to activate the Spo0A protein. An alternative hypothesis is presented in which the sof mutations play the role of bypass mutations for kinases.
Bradykinin-induced bronchoconstriction in humans. Mode of action. (1987)

The effect of bradykinin was studied by inhalation in normal and asthmatic human subjects, as well as on human bronchial smooth muscle in vitro. Bradykinin caused cough and retrosternal discomfort in all subjects and bronchoconstriction in asthmatic subjects. Bradykinin was approximately 10 times more potent than histamine and methacholine, and there was a significant correlation between the subjects' sensitivity to histamine and bradykinin. Bradykinin-induced bronchoconstriction was prolonged when compared with that of histamine and the C-fiber stimulant capsaicin. This bronchoconstriction was subject to tachyphylaxis, which was also associated with desensitization of the subjects to inhaled histamine. The provocative dose causing a 35% fall in specific airway conductance (PD35) was unaffected by aspirin (1 g orally). However, ipratropium bromide (0.25 mg by nebulizer) significantly inhibited the effect of bradykinin, the PD35 being 0.8 mumol (range, 0.16 to 3.4) and 0.15 mumol (range, 0.047 to 1.15) after active dose and placebo, respectively (p less than 0.05). Likewise, cromolyn sodium (40 mg dry powder) also significantly reduced response to bradykinin, with a PD35 of 0.04 mumol (range, 0.13 to 0.31) after placebo and 0.39 mumol (range, 0.05 to 4.45) after SCG (p less than 0.05). Bradykinin only weakly constricted human bronchial smooth muscle in vitro. Bradykinin at 10(-4) caused only 21.5 +/- 5.5% of the maximal carbamylcholine contraction in 11 of 18 airways. Captopril did not enhance the effect of bradykinin. Bradykinin is a potent bronchoconstrictor of human airways in vivo, acting in part through cholinergic mechanisms but not because of the formation of prostaglandins.
Lateral forces on circularly polarizable particles near a surface (2015)

Optical forces allow manipulation of small particles and control of nanophotonic structures with light beams. While some techniques rely on structured light to move particles using field intensity gradients, acting locally, other optical forces can 'push' particles on a wide area of illumination but only in the direction of light propagation. Here we show that spin-orbit coupling, when the spin of the incident circularly polarized light is converted into lateral electromagnetic momentum, leads to a lateral optical force acting on particles placed above a substrate, associated with a recoil mechanical force. This counterintuitive force acts in a direction in which the illumination has neither a field gradient nor propagation. The force direction is switchable with the polarization of uniform, plane wave illumination, and its magnitude is comparable to other optical forces.
Effect of polycrystalline-silicon gate types on the opposite flatband voltage shift in n-type and p-type metal–oxide–semiconductor field-effect transistors for high-k-HfO2 dielectric (2003)

Hafnium dioxide (HfO2) gate dielectrics formed by the atomic layer deposition (ALD) process were fabricated to investigate the flatband voltage shift (ΔVFB) relative to SiO2. It is found that the direction of ΔVFB depends on the Fermi level position in the gate material, which shows respective positive and negative shifts in n-type and p-type metal–oxide–semiconductor field-effect transistors (MOSFETs), regardless of the substrate type. The opposite direction in the flatband voltage shift is attributed to both acceptor- and donor-like interface states existing at the interface between the polycrystalline-silicon (poly-Si) gate and HfO2 dielectric. A model is proposed to explain the effects of poly-Si gate type on the flatband voltage shift in MOSFETs.
Subpicosecond pulse amplification in semiconductor laser amplifiers: theory and experiment (1994)

We present a phenomenological model of subpicosecond pulse evolution in semiconductor laser amplifiers, which includes carrier heating effect, gain dispersion, gain saturation, and three kinds of self-phase modulations (SPM). The results obtained from this model are applied to and found to agree very well with experimental measurements of spectral distortions and time-resolved gain on a semiconductor laser amplifier with 460-fs and 2-ps input pulses. The device parameters that are used to match the experimental results are within a reasonable range, either suggested by previous experiments or by published calculations, The results show that the evolution of the pulses and their spectra is sensitively dependent on the input pulse shape and on a variety of time domain and frequency domain amplitude and phase shaping effects. Matching the theory to the experimental data suggests that among the possible causes of the carrier heating two-photon absorption (TPA) is the most important. This effect of TPA needs to be included to properly account for the observed dependence of the carrier heating gain reduction on the pulse length. By examining separately the contribution of the corresponding terms, we also prove the importance of SPM due to the carrier heating and to the instantaneous nonlinear index in shaping the output spectrum. We compare our model with Agrawal's theory, which is valid for pulses of tens of picosecond duration, and find large differences for subpicosecond pulses. For 2-ps pulses, on the other hand, the differences are fewer and less dramatic. The good agreement of the new model with experiments will now allow diagnostics and predictions of pulse evolution in semiconductor optical amplifiers from the picosecond to the subpicosecond range.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Production of compound A and carbon monoxide in circle systems: an <i>in vitro</i> comparison of two carbon dioxide absorbents* (2004)

Two new generation carbon dioxide absorbents, DrägerSorb Free and Amsorb Plus, were studied in vitro for formation of compound A or carbon monoxide, during minimal gas flow (500 ml x min(-1)) with sevoflurane or desflurane. Compound A was assessed by gas chromatography/mass spectrometry and carbon monoxide with continuous infrared spectrometry. Fresh and dehydrated absorbents were studied. Mean (SD) time till exhaustion (inspiratory carbon dioxide concentration >or= 1 kPa) with fresh absorbents was longer with DrägerSorb Free (1233 (55) min) than with Amsorb Plus (1025 (55) min; p < 0.01). For both absorbents, values of compound A were < 1 ppm and therefore below clinically significant levels, but were up to 0.25 ppm higher with DrägerSorb Free than with Amsorb Plus. Using dehydrated absorbents, values of compound A were about 50% lower than with fresh absorbents and were identical for DrägerSorb Free and Amsorb Plus. With dehydrated absorbents, no detectable carbon monoxide was found with desflurane.
Effect of sulfonic acid group on polyaniline backbone (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of sulfonic acid group on polyaniline backboneJiang Yue, Zhao H. Wang, Keith R. Cromack, Arthur J. Epstein, and Alan G. MacDiarmidCite this: J. Am. Chem. Soc. 1991, 113, 7, 2665–2671Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/ja00007a046https://doi.org/10.1021/ja00007a046research-articleACS PublicationsRequest reuse permissionsArticle Views3624Altmetric-Citations569LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dissociation of the stimulatory activities of staphylococcal enterotoxins for T cells and monocytes. (1990)

The staphylococcal enterotoxins (SEs) are homologous proteins related in their capacity for stimulating both T cells and monocytes. To assess the importance of conserved structure and sequence to functional activity, the role of the disulfide loop and adjacent sequence in these toxins was evaluated. Contrary to previous reports, we demonstrate here that the disulfide loop was required for the mitogenic activity of SEA and SEB. While T cell-stimulatory activity was compromised, reduced and alkylated SEs retained major histocompatibility complex class II-binding and monocyte-stimulatory activities, suggesting that their inability to induce T cell proliferation was due to failure to interact with T cell receptor (TCR) rather than with class II molecules. Reduction and alkylation did not affect the far-ultraviolet circular dichroic spectrum of SEA, suggesting that the loss of mitogenic activity was not associated with significant changes in secondary structure. The disulfide linkage imparts considerable stability to these toxins as peptide cleavages within the loop of SEB were not associated with detectable loss of function, although cleavage in the conserved sequence outside the loop of SEA resulted in loss of mitogenic activity. This report thus establishes a functional role for a conserved element in SEs, the disulfide loop, and further indicates that their class II- and TCR-binding activities can be dissociated.
The Register's Office of New York County (1915)

John J. Hopper, The Register's Office of New York County, Proceedings of the Academy of Political Science in the City of New York, Vol. 5, No. 3, The Government of the City of New York (Apr., 1915), pp. 170-174
VMGrid: A Virtual Machine supported grid middleware (2008)

Many grid middleware such as Globus Toolkit and GPE have started to support virtual machines. They implement the remote control of virtual machine by grid service and make use of virtual machines’ function of quick deployment to construct the execution environment of grid application fast. In order to support virtual machine in grid environment, VMGrid (Virtual Machine Grid) is presented. All services in VMGrid are implemented based on secure shell host protocol (SSH) while Globus Toolkit’s Virtual Workspace is on WSRF. This paper gives a clear description of VMGrid. Some comparisons with Globus Toolkit’s Virtual Workspace in performance are made in this paper. Performance results show that VMGrid virtual workspace atomic services are more effective than that of Globus.
Phosphonium pillar[5]arenes as a new class of efficient biofilm inhibitors: importance of charge cooperativity and the pillar platform (2016)

Biofilm formation, which frequently occurs in microbial infections and often reduces the efficacy of antibiotics, also perturbs many industrial and domestic processes. We found that a new class of water soluble pillar[5]arenes bearing phosphonium moieties (1, 2) and their respective ammonium analogues (3, 4) inhibit biofilm formation with IC50 values in the range of 0.67-1.66 μM. These compounds have no antimicrobial activity, do not damage red blood cell membranes, and do not affect mammalian cell viability in culture. Comparison of the antibiofilm activities of the phosphonium-decorated pillar[5]arene derivatives 1 and 2 with their respective ammonium counterparts 3 and 4 and their monomers 5 and 6, demonstrate that while positive charges, charge cooperativity and the pillararene platform are essential for the observed antibiofilm activity the nature of the charges is not.
A comprehensive systematic review and meta-analysis of pharmacological and dietary supplement interventions in paediatric autism: moderators of treatment response and recommendations for future research (2017)

Few trials reported adequate baseline characteristics to permit detailed analysis of response to treatment. Consideration of geographical location, baseline severity and intellectual function is required to ensure generalizability of results. The use of biological markers and correlates in ASD trials remains in its infancy. There is great need to improve the application of baseline characterization and incorporation of biological markers and correlates to permit selection of participants into homogeneous subgroups and to inform response to treatment in ASD.
A Heterologous Coiled Coil Can Substitute for Helix I of the Sindbis Virus Capsid Protein (2003)

Alphavirus core assembly proceeds along an assembly pathway involving a dimeric assembly intermediate. Several regions of the alphavirus capsid protein have been implicated in promoting and stabilizing this dimerization, including a putative heptad repeat sequence named helix I. This sequence, which spans residues 38 to 55 of the Sindbis virus capsid protein, was implicated in stabilizing dimeric contacts initiated through the C-terminal two-thirds of the capsid protein and nucleic acid. The studies presented here demonstrate that helix I can be functionally replaced by the corresponding sequence of a related alphavirus, western equine encephalitis virus, and also by an unrelated sequence from the yeast transcription activator, GCN4, that was previously shown to form a dimeric coiled coil. Replacing helix I with the entire leucine zipper domain of GCN4 (residues 250 to 281) produced a virus with the wild-type phenotype as determined by plaque assay and one-step growth analysis. However, replacement of helix I with a GCN4 sequence that favored trimer formation produced a virus that exhibited approximately 40-fold reduction in virus replication compared to the wild-type Sindbis virus. Changing residues within the Sindbis virus helix I sequence to favor trimer formation also produced a virus with reduced replication. Peptides corresponding to helix I inhibited core-like particle assembly in vitro. On the basis of these studies, it is proposed that helix I favors capsid protein-capsid protein interactions through the formation of dimeric coiled-coil interactions and may stabilize assembly intermediates in the alphavirus nucleocapsid core assembly pathway.
Logical partition mode physical resource management on the IBM eServer z990 (2004)

The IBM eServerTM z990 provides tremendously increased processor, I/O, and memory capacity exceeding the capability of even the premier IBM operating systems. The modular or book-form system topology of the z990 enables a highly flexible and more cost-effective concurrent upgrade infrastructure, as well as improved hardware failure survivability and serviceability. The multibook form of the z990 has two significant memory access performance issues which are addressed here: First, there is increased cache coherency overhead when the same memory is accessed by central processing units (CPUs) from multiple books; second, access from CPUs to memory on books other than the book on which a CPU is resident is not as efficient as access from the same book. Awareness of this multifold increase in capacity and complexity is effectively managed by the IBM zSeries® logical partition (LPAR) hypervisor, obviating the need for operating system involvement. This paper describes changes made to the zSeries LPAR hypervisor to manage CPU and memory resources on the z990 machine topology.
RESTORATION OF BLURRED IMAGES USING TWO-DIMENSIONAL DIGITAL FILTERS AND NOISE REMOVAL FILTERS. (1984)

On presente de nouvelles techniques deterministes pour restaurer des images floues. On concoit des filtres numeriques bidimensionnels bases sur des pseudo-inverses avec supposee connue la fonction d'etalement d'un point d'un systeme flou