gebhart/patrepeval huggingface dataset:
Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. (1994)

Human immunodeficiency virus 1 (HIV-1) infection is associated with a vigorous cellular immune response that allows detection of cytotoxic T lymphocyte (CTL) activity using freshly isolated peripheral blood mononuclear cells (PBMC). Although restricting class I antigens and epitopes recognized by HIV-1-specific CTL have been defined, the effector cells mediating this vigorous response have been characterized less well. Specifically, no studies have addressed the breadth and duration of response to a defined epitope. In the present study, a longitudinal analysis of T cell receptor (TCR) gene usage by CTL clones was performed in a seropositive person using TCR gene sequences as a means of tracking responses to a well-defined epitope in the glycoprotein 41 transmembrane protein. 10 CTL clones specific for this human histocompatibility leukocyte antigen-B14-restricted epitope were isolated at multiple time points over a 31-mo period. All clones were derived from a single asymptomatic HIV-1-infected individual with a vigorous response to this epitope that was detectable using unstimulated PBMC. Polymerase chain reaction amplification using V alpha and V beta family-specific primers was performed on each clone, followed by DNA sequencing of the V-D-J regions. All 10 clones utilized V alpha 14 and V beta 4 genes. Sequence analysis of the TCR revealed the first nine clones isolated to also be identical at the nucleotide level. The TCR-alpha junctional region sequence of the tenth clone was identical to the junctional region sequences of the other nine, but this clone utilized distinct D beta and J beta gene segments. This study provides evidence that the observed high degree of HIV-1-specific CTL activity may be due to monoclonal or oligoclonal expansion of specific effector cells, and that progeny of a particular CTL clone may persist for prolonged periods in vivo in the presence of a chronic productive viral infection. The observed limited TCR diversity against an immunodominant epitope may limit recognition of virus variants with mutations in regions interacting with the TCR, thereby facilitating immune escape.
Synthesis and acidity of crown ethers with pendant carboxylic acid groups (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and acidity of crown ethers with pendant carboxylic acid groupsRichard A. Bartsch, Gwi Suk Heo, Sang Ihn Kang, Yung Liu, and Jerzy StrzelbickiCite this: J. Org. Chem. 1982, 47, 3, 457–460Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://doi.org/10.1021/jo00342a016RIGHTS & PERMISSIONSArticle Views353Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (603 KB) Get e-Alerts Get e-Alerts
Effect of Liquid Quenching on Hydroprocessing of Heavy Crude Oils in a Fixed-Bed Reactor System (2008)

The effect of liquid quenching during the hydroprocessing of a heavy crude oil in a fixed-bed reactor system was explored. Experiments were carried out at various operating conditions in a pilot plant equipped with two fixed-bed reactors in series loaded with a triple catalyst system and necessary hardware for injecting quench fluids between reactors. The feed and quench liquid were prepared by splitting a heavy crude oil into two fractions, called light and heavy fractions. The heavy fraction was used as the feed to the reactors, whereas the light fraction was injected between reactors as the quenching liquid. To establish a reference case, a conventional hydrogen quenching scheme was also evaluated by injecting hydrogen instead of the light fraction. It was observed that hydrogen quenching produced only marginally better quality because of a more favorable H2/oil profile. Yet, it was determined that this approach (hydrogen quenching) requires the handling of large volumes of gas, which increases compressor capacity and equipment size. Liquid quenching, on the other hand, decreases the reaction severity by increasing the liquid hourly space velocity (LHSV), which affects product quality although not significantly. Compared with hydrogen quenching, liquid quenching dramatically reduces the quench volumetric rate and consequently compression costs, which makes this approach an economically attractive option for industrial application.
The location and characterisation of the O‐linked glycans of the human insulin receptor (2006)

O-linked glycosylation is a post-translational and post-folding event involving exposed S/T residues at beta-turns or in regions with extended conformation. O-linked sites are difficult to predict from sequence analyses compared to N-linked sites. Here we compare the results of chemical analyses of isolated glycopeptides with the prediction using the neural network prediction method NetOGlyc3.1, a procedure that has been reported to correctly predict 76% of O-glycosylated residues in proteins. Using the heavily glycosylated human insulin receptor as the test protein six sites of mucin-type O-glycosylation were found at residues T744, T749, S757, S758, T759, and T763 compared to the three sites (T759 and T763- correctly, T756- incorrectly) predicted by the neural network method. These six sites occur in a 20 residue segment that begins nine residues downstream from the start of the insulin receptor beta-chain. This region which also includes N-linked glycosylation sites at N742 and N755, is predicted to lack secondary structure and is followed by residues 765-770, the known linear epitope for the monoclonal antibody 18-44.
Complex Local Dynamics in DNA on the Picosecond and Nanosecond Time Scales (2002)

Time-resolved Stokes shift measurements of the local structural relaxation of three DNA oligonucleotides are presented. Logarithmic relaxation is seen for over three decades in time (40 ps-40 ns), indicating a complex relaxation among a large number of conformational substates. The observed relaxation is the same in all the sequences. Sequence dependence of the localized dynamics of DNA does not appear within this time range. We infer that 30%-50% of the relaxation is faster than 40 ps, has a nonlogarithmic decay and has a sequence dependent amplitude.
Egypt's Labor Pains: For Workers, the Revolution Has Just Begun (2011)

This past spring, Western and Egyptian media alike attributed the explosive Tahrir Square protests to organizing by middle-class movements of students and intellectuals, battling for political freedom and armed with social media. This popular narrative holds that it was only when young people ignited a popular uprising that Egyptian workers shut down the country's ports and public services in solidarity. But history indicates the opposite, that years of labor organizing laid the groundwork for today's protests and will determine whether working Egyptians have a stake in the state that is emerging.
Thermoelectric cooler/heater controlled crystal oscillator (TECXO) (2003)

A development is described that enables the operation of oven-controlled crystal oscillators (OCXOs) for military or special applications over the extended temperature range of -55 degrees C up to +120 degrees C in a moderately sized case, and with moderate power consumption. The implementation is a device with a thermoelectric (TE) cooler component that is a plate, one side of which is cold and the other hot. The cold side is attached to the device to be cooled, and the hot side to a heatsink. The amount of absorbed heat or the cooling level are proportional to the direct current passing through the component. In order to evaluate the potential advantages of the TECXO, a basic prototype has been developed in the laboratories of TFL. The performance of the device has been measured and analyzed. The conclusions drawn are detailed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Indoor air quality: The hidden side of the indoor environment (1996)

The physical environment can be defined and understood in manv different ways, both from its nature, e.g., thermal, accoustic, etc., or its dimension, e.g., global, local, urban, indoors. The indoor environment is much more than the space or the light effects; it is the result of a complex concurrence of several parameters. To have a good indoor environment means to assure the avoidance of a wide number of disturbances such as noise, glare, thermal stress and, a somehow hidden factor the indoor air pollution. Indoor air qunlity depends strongly on the occupancy pattems of the building but it is recognized now that it is mainly affected by the design options and decisions regarding the use of mechanical ventilation or HVAC systems and of the materials to be adopted in the fabrics and fumiture. The challenge goes beyond the use of solar devices or the adoption of recycled materials in buildings as ways to care about the global or local environment. The challenge is to design healthy buildings, i.e., buildings environment friendly, indoors as well as outdoors.
Ensemble of Deep Convolutional Neural Networks for Learning to Detect\n Retinal Vessels in Fundus Images (2016)

Vision impairment due to pathological damage of the retina can largely be\nprevented through periodic screening using fundus color imaging. However the\nchallenge with large scale screening is the inability to exhaustively detect\nfine blood vessels crucial to disease diagnosis. In this work we present a\ncomputational imaging framework using deep and ensemble learning for reliable\ndetection of blood vessels in fundus color images. An ensemble of deep\nconvolutional neural networks is trained to segment vessel and non-vessel areas\nof a color fundus image. During inference, the responses of the individual\nConvNets of the ensemble are averaged to form the final segmentation. In\nexperimental evaluation with the DRIVE database, we achieve the objective of\nvessel detection with maximum average accuracy of 94.7\\% and area under ROC\ncurve of 0.9283.\n
Causes of haze of low-density polyethylene blown films (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCauses of haze of low-density polyethylene blown filmsFerdinand C. Stehling, C. Stanley Speed, and Lowell WestermanCite this: Macromolecules 1981, 14, 3, 698–708Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://doi.org/10.1021/ma50004a047RIGHTS & PERMISSIONSArticle Views696Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Study of the E2 gene product of the cottontail rabbit papillomavirus reveals a common mechanism of transactivation among papillomaviruses (1988)

The long control region (LCR) of the cottontail rabbit papillomavirus (CRPV) harbors a transcriptional promoter which can be transactivated, as reflected by cat gene expression, by cotransfection with plasmids which express the intact E2 open reading frame of CRPV, human papillomavirus type 18 (HPV18), and bovine papillomavirus type 1 (BPV1). The E2 protein of CRPV can also transactivate the LCRs of BPV1, HPV1, and HPV18 inserted in front of the cat gene in enhancer or promoter configuration. Competition experiments in vivo and binding studies with CRPV E2 protein synthesized in vitro suggest that the different E2 proteins transactivate transcription by a common mechanism involving binding to the same ACCG-CGGT target sequence. The C-terminal part of the protein is necessary for its DNA-binding function. Analysis of the transactivation data and of the LCR sequences of these four viruses suggests that the two cutaneous viruses (CRPV and BPV1) present a similar pattern of promoter regulation but that the activity of the promoters of genital human viruses is less dependent on E2 regulation and is at least partially regulated by cellular factors.
Secure SMS messaging using Quasigroup encryption and Java SMS API. (2003)

SMS (Short Message Service) is a widely used service for brief communication. Occasionally the data sent using SMS services is confidential in nature and is desired not to be disclosed to a third party. In this paper an application for sending encrypted SMS messages using cryptographic methods based on theory of quasigroups is proposed. The encryption algorithm is characterized by a secret key. The application is developed using programming language Java and the J2ME environment available in several mobile devices on the market today.
A Brain-Specific Homeobox Gene, <i>Bsx</i>, Is Essential for Proper Postnatal Growth and Nursing (2007)

To investigate in vivo roles of a murine hypothalamic homeobox gene, Bsx, we generated and analyzed two mutant alleles, Bsx(DeltaHD) and Bsx(lacZ). Bsx(DeltaHD) lacks the homeodomain, and Bsx(lacZ) is an insertion of a lacZ reporter gene. Bsx-lacZ expression was detected in the hypothalamus and pineal gland and reiterates Bsx expression. Bsx homozygous mutant mice were born at the expected Mendelian ratio, but their growth was impaired. Offspring from Bsx homozygous mutant females exhibited a low survival rate due to a nursing defect. Mammary glands of the mutant females developed normally during pregnancy; however, they involuted quickly after parturition. These results demonstrate that Bsx is required for postnatal growth and maintenance of lactating mammary glands. Thus, mouse Bsx is likely involved in systemic control of suppression of apoptosis of postpartum mammary epithelial cells.
A visionary look at aviation surveillance systems (1995)

The FAA's future aviation surveillance systems fall into four categories: Automatic Dependent Surveillance (ADS) will be used in the oceanic environment; ADS-Broadcast (ADS-B) will be used in the domestic en route environment; ADS-B will be used with a secondary radar backup in the terminal area; and ADS-B will be used with primary radar backup within the Airport Surface Traffic Automation (ASTA) system on the airport's surface environment. Two other systems introduced in this paper are Cockpit Display of Traffic Information (CDTI) and Traffic Advisory and Collision Avoidance System (TCAS). All these systems will use navigational signals emitted by the Global Positioning System (GPS) constellation of satellites.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Parasitic excitation of circular antenna arrays (1961)

A method of calculating the radiation pattern of a circular antenna array of parallel monopoles or dipoles using symmetrical components is presented. The results obtained when only one element of the array is excited are not particularly good. However, if an additional element is added at the center of the array a fairly good directional pattern results. The sidelobe level is dependent upon the tuning of this central element, and a graphical analysis is given which optimizes this tuning. Calculated and measured patterns are shown and compared. Sidelobe levels of 15 db, and a beamwidth of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">78\deg</tex> are typical. The principal advantage of this antenna lies in the fact that the pointing of the beam can be changed by simply changing the element that is excited.
Programming for parallelism and locality with hierarchically tiled arrays (2006)

Tiling has proven to be an effective mechanism to develop high performance implementations of algorithms. Tiling can be used to organize computations so that communication costs in parallel programs are reduced and locality in sequential codes or sequential components of parallel programs is enhanced.In this paper, a data type - Hierarchically Tiled Arrays or HTAs - that facilitates the direct manipulation of tiles is introduced. HTA operations are overloaded array operations. We argue that the implementation of HTAs in sequential OO languages transforms these languages into powerful tools for the development of high-performance parallel codes and codes with high degree of locality. To support this claim, we discuss our experiences with the implementation of HTAs for MATLAB and C++ and the rewriting of the NAS benchmarks and a few other programs into HTA-based parallel form.
Magnetic resonance imaging of the prostate. (1985)

Twenty-two normal volunteers and 32 patients with either benign prostatic hypertrophy or prostatic carcinoma were examined by magnetic resonance imaging (MRI). The images were of high quality and clearly demonstrated the prostate gland and the surrounding anatomy but were of limited value in differentiating between benign and malignant prostatic disease. Using a specific pulse sequence, the authors were able to visualize what they believed to be the periprostatic venous plexus and suggest that the demonstration of this venous plexus may be of value in showing extraglandular spread of carcinoma of the prostate.
Two-photon polymerization of microneedles for transdermal drug delivery (2010)

It is anticipated that the use of two-photon polymerization as well as two-photon polymerization-micromolding for fabrication of microneedles and other microstructured drug delivery devices will increase over the coming years.
Sport and national identity: a geographical view (1986)

(1986). Sport and national identity: a geographical view. The International Journal of the History of Sport: Vol. 3, No. 1, pp. 18-41.
New mini-ColE1 as a molecular cloning vehicle (1977)

A new mini-ColE1 plasmid, designated pAC105, was isolated. It has a molecular weight of 1.6 X 10(6) and carries information for its self-replication as well as information for conferring colicin E1 immunity upon its host. Furthermore, pAC105 undergoes replication in the presence of chloramphenicol even when a foreign deoxyribonucleic acid (pSC101) is inserted into its single EcoRI restriction site. Studies in minicell-producing strains demonstrate that pAC105 codes for only two or three polypeptides of low molecular weight. The advantages of using it as a molecular cloning vehicle are discussed.
Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. (1991)

The mammalian transcription factor AP-2 is a sequence-specific DNA-binding protein expressed in neural crest lineages and regulated by retinoic acid. Here we report a structure/function analysis of the DNA-binding and transcription activation properties of the AP-2 protein. DNA contact studies indicate that AP-2 binds as a dimer to a palindromic recognition sequence. Furthermore, cross-linking and immunoprecipitation data illustrate that AP-2 exists as a dimer even in the absence of DNA. Examination of cDNA mutants reveals that the sequences responsible for DNA binding are located in the carboxy-terminal half of the protein. In addition, a domain mediating dimerization forms an integral component of this DNA-binding structure. Expression of AP-2 in mammalian cells demonstrates that transcriptional activation requires an additional amino-terminal domain that contains an unusually high concentration of proline residues. This proline-rich activation domain also functions when attached to the heterologous DNA-binding region of the GAL4 protein. This study reveals that although AP-2 shares an underlying modular organization with other transcription factors, the regions of AP-2 involved in transcriptional activation and DNA binding/dimerization have novel sequence characteristics.
Speech Recognition and the Telecommunications Emergency Decision Support System (1991)

The purpose of this thesis is to provide a feasibility study for incorporating speech recognition into the Telecommunications Emergency Decision Support System (TEDSS) developed by the National Communications System (NCS) and contained on a Compaq 386. The three types of speech recognition systems that were used are: the DragonDictate, a software driven system, the Verbex Series 5000, a system contained in a peripheral device, and the KeyTronic Speech Recognition System, a system contained in a keyboard in addition to using speech software. A prototype was developed using the speech systems to determine whether or not TEDSS could be combined successfully with speech recognition. The results indicate that the incorporation of speech recognition into TEDSS is possible with some modifications to TEDSS software and to the Compaq 386.
Conditions de possiblité d'une anthropologie totalisatrice et intégrative des diverses sciences de l'homme (I) (1970)

Conditions de possiblité d'une anthropologie totalisatrice et intégrative des diverses sciences de l'homme (I). Un article de la revue Laval théologique et philosophique (Volume 26, numéro 1, 1970, p. 3-110) diffusée par la plateforme Érudit.
Temporal Processing in Cat Primary Auditory Cortex (1997)

In this short review, we discuss several aspects of how temporal coding is reflected in the response of primary auditory cortical neurons. We attempt to establish a link between several different temporal response properties including onset latency, response strength to repetitive stimuli, and the recovery of a response from suppression by a preceding signal. The results suggest a relationship between temporal effects that are expressed at quite different time scales. The results are discussed in relation to spatial representational properties and to coding in other sensory cortices.