gebhart/patrepeval huggingface dataset:
Deletion of autophagy inducer<i>RB1CC1</i>results in degeneration of the retinal pigment epithelium (2015)

Autophagy regulates cellular homeostasis and response to environmental stress. Within the retinal pigment epithelium (RPE) of the eye, the level of autophagy can change with both age and disease. The purpose of this study is to determine the relationship between reduced autophagy and age-related degeneration of the RPE. The gene encoding RB1CC1/FIP200 (RB1-inducible coiled-coil 1), a protein essential for induction of autophagy, was selectively knocked out in the RPE by crossing Best1-Cre mice with mice in which the Rb1cc1 gene was flanked with Lox-P sites (Rb1cc1(flox/flox)). Ex vivo and in vivo analyses, including western blot, immunohistochemistry, transmission electron microscopy, fundus photography, optical coherence tomography, fluorescein angiography, and electroretinography were performed to assess the structure and function of the retina as a function of age. Deletion of Rb1cc1 resulted in multiple autophagy defects within the RPE including decreased conversion of LC3-I to LC3-II, accumulation of autophagy-targeted precursors, and increased numbers of mitochondria. Age-dependent degeneration of the RPE occurred, with formation of atrophic patches, subretinal migration of activated microglial cells, subRPE deposition of inflammatory and oxidatively damaged proteins, subretinal drusenoid deposits, and occasional foci of choroidal neovascularization. There was secondary loss of photoreceptors overlying the degenerated RPE and reduction in the electroretinogram. These observations are consistent with a critical role of autophagy in the maintenance of normal homeostasis in the aging RPE, and indicate that disruption of autophagy leads to retinal phenotypes associated with age-related degeneration.
Early albumin infusion improves global and local hemodynamics and reduces inflammatory response in hemorrhagic shock (2002)

Albumin treatment of hemorrhagic shock improves microcirculation and global hemodynamics and attenuates the inflammatory response to reperfusion. It may provide clinical benefit when applied at an early stage of reperfusion during hemorrhagic shock.
Currentcy: Unifying Policies for Resource Management (2002)

The global system nature of energy creates challenges in developing operating system policies to effectively manage energy consumption. Our proposed currentcy model creates the framework for the operating system to manage energy as a first-class resource. Furthermore, currentcy provides a powerful mechanism to formulate unified energy management policies across diverse competing applications and spanning devices with very different power characteristics. We claim that unifying energy management enables more coherent and efficient energy consumption. This paper
Design and performance of a SWIR HgCdTe hybrid module for multispectral linear array/landsat applications (1985)

A modular focal-plane array composed of a SWIR photovoltaic HgCdTe/Si hybrid module has been developed for NASA Earth Resources application. Detector arrays have been fabricated for use in the 1.0-2.5-µm wavelength regime using ion-implanted planar photodiodes formed in liquid-phase epitaxial layers grown on CdZnTe substrates. The resulting diodes have shown <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R_{0}A_{J}</tex> products as high as 2 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> Ω . cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 200 K. The detector design features a gate and a guard structure to reduce leakage current and provide improved optical definition. The multiplexer is a low-noise n-channel direct readout circuit with a 256 : 2 architecture. When the hybrid is operated at 145 K, nonuniformity of responsivity under uniform illumination is less than 8 percent, operability is 99 percent, D* is 82-percent BLIP at 4.7 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> ph/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . s for a 50-percent quantum efficiency detector, the nonlinearity of the modules is less than 1 percent, and the crosstalk is less than 5 percent.
Visible light road-to-vehicle communication using high-speed camera (2008)

We have been proposing visible light road-to-vehicle communication at intersection, using LED traffic light as the transmitter and on-vehicle high-speed camera as the receiver. Visible light communication is a wireless communication method using luminance, transmitting data by emitting light. Thus when we use image sensor as the receiver, detection of the transmitter is required to enable the communication. In this paper, we propose transmitter detection algorithm supposed that the sequence is captured at 1000fps. We also made experiments to verify our algorithm, using the sequence captured by a high-speed camera fixed on a vehicle which is running at 30km/h.
Interfacing 5G Orchestrator With Data Analytics Functions [From the Guest Editors] (2020)

During the past few years, research and standardization communities have worked collaboratively to develop a composable 5G network for a digitized, connected world of humans and machines. This has been evident in every segment of the new communication system, including the powerful and reachable air interface supported by New Radio, multiaccess edge computing (MEC), a new transport network featuring dense wavelength-division multiplexing, the service-based architecture of the 5G core network, end-to-end (E2E) network slicing, network function virtualization (NFV) and service automation, and so on. Using predefined policies, this softwaredriven network is tactical, restructures domains, and mobilizes resources in response to traffic changes. Therefore, the internal network interfaces, resources, functionality, and task assignment are dynamically adapted through main network orchestrators that govern all components either directly or through specific elements.
Logic gate modules using opto-optical birefringence switching (1991)

A birefringence phenomenon is used to construct Boolean logic gates that output three logic functions. Logic gate modules are proposed that consist of Bi12SiO20 opto-optical birefringence switches, LiNbO3 electro-optical half-wave plates, and calcite plates. The gate can be driven by optical inputs and can also be electrically programmed for different logic operations. An array-packed solid-state module is described.
MiR-101 and miR-144 Regulate the Expression of the CFTR Chloride Channel in the Lung (2012)

The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is a chloride channel that plays a critical role in the lung by maintaining fluid homeostasis. Absence or malfunction of CFTR leads to Cystic Fibrosis, a disease characterized by chronic infection and inflammation. We recently reported that air pollutants such as cigarette smoke and cadmium negatively regulate the expression of CFTR by affecting several steps in the biogenesis of CFTR protein. MicroRNAs (miRNAs) have recently received a great deal of attention as both biomarkers and therapeutics due to their ability to regulate multiple genes. Here, we show that cigarette smoke and cadmium up-regulate the expression of two miRNAs (miR-101 and miR-144) that are predicted to target CFTR in human bronchial epithelial cells. When premature miR-101 and miR-144 were transfected in human airway epithelial cells, they directly targeted the CFTR 3'UTR and suppressed the expression of the CFTR protein. Since miR-101 was highly up-regulated by cigarette smoke in vitro, we investigated whether such increase also occurred in vivo. Mice exposed to cigarette smoke for 4 weeks demonstrated an up-regulation of miR-101 and suppression of CFTR protein in their lungs. Finally, we show that miR-101 is highly expressed in lung samples from patients with severe chronic obstructive pulmonary disease (COPD) when compared to control patients. Taken together, these results suggest that chronic cigarette smoking up-regulates miR-101 and that this miRNA could contribute to suppression of CFTR in the lungs of COPD patients.
Epidemiological study of Norwalk virus infections in Japan and Southeast Asia by enzyme-linked immunosorbent assays with Norwalk virus capsid protein produced by the baculovirus expression system (1994)

In this study, we investigated Norwalk virus (NV) antigen and antibody to recombinant NV (rNV) in human populations in Japan and Southeast Asia by enzyme-linked immunosorbent assays (ELISAs). Baculovirus-expressed recombinant NV (rNV) capsid protein was used for preparing antisera to rNV or used as an antigen for detecting antibody to rNV. The ELISAs were specific for NV and had sensitivities equivalent to or higher than those of the previously developed radioimmunoassays. In 159 stool samples obtained from children, mainly younger than 10 years old, with acute gastroenteritis due to small round structured viruses in Japan, only 1 was positive for NV antigen. The pattern of acquisition of antibody to rNV was quite different from those of antibodies to group A rotavirus and human calicivirus Sapporo (HuCV-Sa) strain. The prevalence of antibody to rNV remained at a low level throughout childhood and then showed a steep rise during school age and early adulthood in Japan. A high prevalence of antibody was observed in samples collected from healthy adults in Japan and Southeast Asia. These results suggested that NV infection is common in adults in Japan and Southeast Asia but may be rare in infants in Japan. The HuCV-Sa strain was negative by the ELISA, and no serological relationship between NV and the HuCV-Sa strain was found. NV may be quite different from the HuCV-Sa strain, although both viruses are classified in the family Caliciviridae.
Laser selective chemistry—is it possible? (1980)

One of the main goals of chemists is to understand the “alchemy” that leads to the building and breaking of molecules. There are many different ways of approaching this goal. One of these is photochemistry, the cracking of molecules by adding energy in the form of light to break bonds in the molecules. The resulting bond breakage is in most cases limited by statistical thermodynamic laws. With sufficiently brief and intense laser radiation properly tuned to specific resonances, we hope to bypass the statistical laws and break molecules precisely where we want to break them. Intellectually this is a challenging problem; if we succeed, laser selective chemistry may also have application in various areas of pure and applied chemistry and, perhaps, in medicine.
Regional haemodynamic responses to pituitary adenylate cyclase‐activating polypeptide and vasoactive intestinal polypeptide in conscious rats (1994)

1. Regional haemodynamic responses to the homologous peptides, pituitary adenylate cyclase-activating peptide (1-27) (PACAP27) and vasoactive intestinal polypeptide (VIP) were assessed by giving 20 min infusions (1.5-15 nmol kg-1 h-1) in conscious, chronically-instrumented, Long Evans rats. 2. PACAP27 caused dose-dependent depressor and tachycardic effects associated with renal, mesenteric and hindquarters vasodilatations, although only in the latter vascular bed was there a sustained increase in flow. 3. VIP caused dose-dependent depressor and tachycardic effects that were not significantly different from those caused by equimolar doses of PACAP27. However, the hindquarters vasodilator effects of VIP (at 7.5 and 15 nmol kg-1 h-1) were greater than those of PACAP27 (at the same doses), and accompanied by reductions in renal and mesenteric flows and conductances. 4. In the presence of the nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME; 11 mumol kg-1 h-1), there was significant inhibition of the hindquarters vasodilator effects of PACAP27 and VIP (at 7.5 and 15 nmol kg-1 h-1). Under these circumstances the renal and mesenteric vasoconstrictor effects of VIP were abolished. 5. The beta 2-adrenoceptor antagonist, ICI 118551 (670 nmol kg-1 bolus, 335 nmol kg-1 h-1 infusion), reduced the matched hindquarters vasodilator responses to PACAP27 (15 nmol kg-1 h-1) and VIP (7.5 nmol kg-1 h-1), and also abolished the renal vasoconstrictor effects of VIP. 6. The AT1-receptor antagonist, losartan potassium (20 mumol kg-1), had no significant effect on the haemodynamic response to PACAP27 (15 nmol kg-1 h-1), but augmented the hypotensive action of VIP (7.5 nmol kg-1 h-1). This influence of losartan was associated with conversion of the renal and mesenteric vasoconstrictor effect of VIP to vasodilatation. 7. Our findings show that similar changes in mean systemic arterial blood pressure in response to PACAP27 and VIP conceal substantial differences in their regional haemodynamic actions. Although the hindquarters vasodilator effects of both peptides involve NO- and Beta2-adrenoceptor-mediated mechanisms,it appears that activation of the renin-angiotensin system contributes significantly to the haemodynamic effects of VIP, but not to those of PACAP27.
A breakthrough for prepaid payment: End to end token exchange and management using secure SSL channels created by EAP-TLS smart cards (2011)

In this paper we present an innovative architecture for prepaid services. Digital tokens are securely exchanged between EAP-TLS smart cards used both by merchant and customer. We describe the global framework that comprises a back-office server delivering tokens, a front-office server collecting tokens from merchant terminal, merchants and customers equipped with smart cards. We detail data exchange choreography and discuss performances issues for the experimental platform built with commercial devices.
β‐Amyloid efflux mediated by p‐glycoprotein (2001)

A large body of evidence suggests that an increase in the brain beta-amyloid (Abeta) burden contributes to the etiology of Alzheimer's disease (AD). Much is now known about the intracellular processes regulating the production of Abeta, however, less is known regarding its secretion from cells. We now report that p-glycoprotein (p-gp), an ATP-binding cassette (ABC) transporter, is an Abeta efflux pump. Pharmacological blockade of p-gp rapidly decrease extracellular levels of Abeta secretion. In vitro binding studies showed that addition of synthetic human Abeta1-40 and Abeta1-42 peptides to hamster mdr1-enriched vesicles labeled with the fluorophore MIANS resulted in saturable quenching, suggesting that both peptides interact directly with the transporter. Finally, we were able to directly measure transport of Abeta peptides across the plasma membranes of p-gp enriched vesicles, and showed that this phenomenon was both ATP- and p-gp-dependent. Taken together, our study suggests a novel mechanism of Abeta detachment from cellular membranes, and represents an obvious route towards identification of such a mechanism in the brain.
Nonlinear Ion Cyclotron Resonance in Electromagnetic Wave with Non-Uniform Amplitude (1994)

The cyclotron motion of ion in a nonuniform electromagnetic wave is analysed using the multiple-time-scale-expansion method. A set of nonlinear equations which describes the evolutions of the gyroradius ρ, the gyrophase β, and the average velocity < v z > along the magntic field B 0 is obtained. The set is found exactly integrable and three conservation relations are obtained for an arbitrary harmonic among ρ, β, < v z > and the drift coordinates perpendicular to B 0 . The theory includes the one obtained for the fundamental harmonic and a uniform amplitude wave and is also applied to ion acceleration in a non-uniform field near an antenna used in an ion-cyclotron-range-of-frequencies (ICRF) wave heating. Thus the theory seems to be more rigorous and general than the previous ones.
BIOGLUE: A REVIEW OF THE USE OF THIS NEW SURGICAL ADHESIVE IN THORACIC SURGERY (2005)

Our results in this particular patient group indicate that BioGlue is a reliable adjunct in the reduction of alveolar air leaks. Although further studies are necessary to establish the role of BioGlue in thoracic surgery in comparison to other sealants, these initial results are promising.
Photonic microwave filtering using coherently coupled integrated ring resonators (1999)

Filtering of microwave signals using coupled photonic ring resonators fabricated in the silica waveguide technology is described. Integrated thermo-optic phase shifters allow for control of the optical phase and the passband shape. Tuning of the microwave passband via optical wavelength and phase is demonstrated. ©1999 John Wiley & Sons, Inc. Microwave Opt Technol Lett 21: 90–93, 1999.
Quantified performance (2013)

A look at how athletic performance can be measured outside of the laboratory.
Psychological support and recovery in the aftermath of natural disaster (2012)

Natural disasters can result in a range of mental health outcomes among the affected population. Appropriate mental health interventions are required to promote recovery. In the aftermath of the 2009 bushfires in Victoria, Australia, a collaboration of trauma experts, the Australian and Victorian state governments and health professional associations developed an evidence-informed three-level framework outlining recommended levels of care. The framework was underpinned by an education and training agenda for mental health professionals. This framework has been successfully applied after further natural disasters in Australia. This paper outlines the steps included in each of the levels.
Analysis of Crude methanol and Byproduced Higher Alcohols by Gas Chromatography (1959)

A crude methanol synthesized in plant from natural gas as a raw material contains a small amount of impurities of several kinds Confirmation of these by qualitative analysis can be made by means of usual chemical and physical methods but there are many difficulties for their quantitative determination. Qualitative and quantitative determinations are made simply by use of Fischer Scientific Company's partitioner gas chromatography.Impurities detected at the end of catalytic process by the gas chromatography are methyl ether, methyl formate, acetone and other C: O compounds, benzene, cyclohexane, methylcyclohexane and other aromatic compounds, higher alcohols having 2-7 carbon atoms, and normal paraffins having 5-9 carbon atoms.Compounds having higher boiling points than these require considerable time for analysis and they are left undetermined.Detailed analytical values of aromatic compounds and higher alcohols in the crude methanol are not given in this report as their amount are very small.Although the qualitative analysis by gas chromatography can be made by measuring the retention time but its reconfirmation is made by infrared absorption of a fraction from redistilled portion and by measuring the melting point of its urethan derivative.
Adhesion of Cultured Fibroblasts to Insoluble Analogues of Cell-Surface Carbohydrates (1973)

Animal cells are coated with complex carbohydrates. Insoluble analogues of these substances were prepared by coupling monosaccharides to Sephadex beads (crosslinked dextran), and the interactions between these derivatives and three established cell lines were studied. A virally transformed fibroblast, simian virus 40-transformed 3T3 cells, adhered to the beads derivatized with D-galactose, but did not adhere to the corresponding beads derivatized with D-glucose or N-acetyl-D-glucosamine. Cells that adhered to the galactose-beads appeared to initiate a nucleation process in that they became more adhesive towards the cells in suspension, leading to the formation of large aggregates containing both cells and galactose-beads. The results suggest that specific carbohydrates are involved in the processes of cell recognition or cell adhesion, or both.
Potent antitumor activity of Rubia cordifolia (2010)

Cancer is a leading cause of death. Rubia cordifolia is a traditional ayurvedic medicine being used as a remedy for various ailments. Dichloromethane fraction of Rubia cordifolia extract exhibited potent inhibition of human leukaemia cell line and human histolytic lymphoma cell line while was found to be lesser active against normal human kidney cells displaying safety for normal cells. Rubia cordifolia can be a source of potent pharmacophore for treatment of disease like cancer. Keywords: Rubia cordifolia; Cell line; Anticancer
[Responses of ligamentous fibroblasts to mechanical stimulation]. (1995)

Mechanical stimulation, as provided by physiotherapy or controlled motion is essentially the only factor able to improve anterior cruciate ligament (ACL) healing. We investigate the cellular effects of such stimulus. Two types of stimulations are applied on canine ACL fibroblasts: repetitive stretch of an elastomeric adhesion substrate and a laminar flow of culture media over the culture surface. Cell orientation, proliferation rate, synthesis and type of collagen as well as proteoglycans (PG) synthesis and hydrodynamic characteristics have been studied. According to our results, the fibroblasts tend to align perpendicularly to the deformation axis of their substrate, and along a laminar flow. The shear stress induced by the laminar flow does not modify significantly proliferation rate nor extracellular matrix synthesis. Substrate stretching however, increases proliferation rate, collagen synthesis, mostly type III, and PG synthesis, principally of small sizes. The characteristics of fibroblasts submitted to repeated deformation match those of fibroblasts from ligament scar tissues. Their orientation perpendicular to substratum deformation differs from the one usually encountered in the undamaged tissue: aligned on the ligament axis.
The parties‐do‐matter hypothesis and the case of the federal republic of Germany (1995)

According to the parties‐do‐matter hypothesis, differences in policy outputs and outcomes are associated with ‐ and, by inference, are dependent upon ‐ differences in the partisan composition of government. It is to a critical evaluation of the parties‐do‐matter view and its applicability to non‐majoritarian and ‘semi‐sovereign’ states, such as the Federal Republic of Germany, that attention is given in this article. It is argued that the parties‐do‐matter hypothesis deserves credit for its robust explanatory power. However, a full understanding of the magnitude of party affects requires systematic analysis of differences in the room for manoeuvre that constitutional structures, or state structures, have generated for incumbent parties as well as for opposition parties. Bringing state structures back into comparative public policy studies also helps to solve a puzzle which has thus not been well answered: why is it that particular radical policy change has taken place in one group of democracies, and why is it that a remarkable degree of policy continuity and more muted partisan cycles in public policy tends to be characteristic of another group of constitutional democracies?
Adsorption of carbon monoxide on activated carbon impregnated with metal halide (1996)

Abstract Activated carbon was impregnated with a metal halide, and adsorption and desorption characteristics of CO on the carbon were measured by fixed‐bed runs. It was found that the impregnation of PdCl 2 or CuCl effectively increases CO absorption. PdCl 2 /CuCl‐impregnated carbons were characterized by N 2 adsorption, SEM, EPMA, and XPS. Adsorption isotherms of CO were also measured on these carbons, and the influence of the loading of impregnant on CO adsorption was experimentally elucidated. A selection procedure of impregnant was proposed based on the frontier orbital theory. The perturbation energy for molecular orbital mixing was estimated by the HOMO – LUMO interaction. CO adsorption on impregnated carbons was qualitatively interpreted using the perturbation energy, and the energy was regarded as an index of impregnant selection.