gebhart/patrepeval huggingface dataset:
Generalized coherent states, reproducing kernels, and quantum support vector machines (2017)

The support vector machine (SVM) is a popular machine learning classification method which produces a nonlinear decision boundary in a feature space by constructing linear boundaries in a transformed Hilbert space. It is well known that these algorithms when executed on a classical computer do not scale well with the size of the feature space both in terms of data points and dimensionality. One of the most significant limitations of classical algorithms using non-linear kernels is that the kernel function has to be evaluated for all pairs of input feature vectors which themselves may be of substantially high dimension. This can lead to computationally excessive times during training and during the prediction process for a new data point. Here, we propose using both canonical and generalized coherent states to calculate specific nonlinear kernel functions. The key link will be the reproducing kernel Hilbert space (RKHS) property for SVMs that naturally arise from canonical and generalized coherent states. Specifically, we discuss the evaluation of radial kernels through a positive operator valued measure (POVM) on a quantum optical system based on canonical coherent states. A similar procedure may also lead to calculations of kernels not usually used in classical algorithms such as those arising from generalized coherent states.
A CD8 T Cell/Indoleamine 2,3‐Dioxygenase Axis Is Required for Mesenchymal Stem Cell Suppression of Human Systemic Lupus Erythematosus (2014)

We found a previously unrecognized CD8+ T cell/IFNγ/IDO axis that mediates the therapeutic effects of allogeneic MSCs in lupus patients.
Kinematic sample mounting system for accurate positioning of transferrable samples (2000)

A design is reported for a system of transferrable sample holders and mating experimental stations, that allows samples to be transferred between preparation and analysis tools with high positional accuracy. The sample holders are designed to be manipulated/transported using standard “ESCA stub” compatible hardware. Provisions are made for heating, cooling, and temperature measurement.
Effect of hemorrhagic shock on conjunctival and transcutaneous oxygen tensions in relation to hemodynamic and oxygen transport changes (1984)

To evaluate possible physiologic mechanisms in hemorrhagic shock, sequential hemodynamics, O2 transport, conjunctival O2 (PcjO2), transcutaneous blood gases (PtcO2, PtcCO2), and core and conjunctival temperature (Tcore, Tcj) were measured during a control period, after hemorrhage, after reinfusion of the shed blood, and subsequently during terminal normovolemic shock in eight anesthetized dogs. The PtcO2 sensor requires surface heating to 44 degrees or 45 degrees C, whereas the PcjO2 sensor measures surface temperature but does not heat the tissue, thus avoiding heat-induced artifacts. Shortly after onset of hemorrhage, hemodynamic variables, bulk O2 transport, and tissue O2 tensions decreased abruptly. Prolongation of hemorrhage further deteriorated these variables. Reinfusion of the shed blood returned all values except PcjO2 to the normal range. In the terminal stage, all variables except PaO2 again deteriorated; decreased O2 transport impaired oxygen consumption, which in turn reduced both central and peripheral heat production. Lowered oxygen consumption, Tcore and Tcj reflect decreases in total-body and local tissue metabolism. These data are consistent with the concept that tissue O2 tension represents the balance between O2 supply and O2 demand and thus reflects overall O2 metabolism, which may be rate-limited by circulatory deficiencies.
A Method of Measuring the Field Strength of High-Frequency Electromagnetic Fields (1948)

An analysis of a case of an electron beam directed parallel to a uniform steady magnetic field with a high-frequency electromagnetic field at right angles to the magnetic field results in a relation among the variables which is particularly simple, if the magnetic field is adjusted so that e <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</inf> s/ mc ωco wherωco is the frequency of the electromagnetic field (Gaussian units). One use of the relation mentioned is that of measuring the field strength of the high-frequency field.
Duration of Suppression of Adrenal Steroids after Glucocorticoid Administration (2010)

Hydrocortisone has long been the treatment of choice for congenital adrenal hyperplasia (CAH). However, treatment with this medication remains problematic. Patients with 21-hydroxylase deficiency CAH have significant diurnal variation in the secretion of 17-hydroxyprogesterone (17OHP). When considering treatment strategies, this variation must be considered along with the pharmacokinetic and pharmacodynamic properties of exogenous glucocorticoids. Orally administered hydrocortisone is highly bioavailable, but it has a short time to maximum concentration (T(max)) and half life (T(1/2)). While prednisone has a somewhat longer T(max) and T(1/2), they remain relatively short. There have been several studies of the pharmacodynamics of hydrocortisone. We present data indicating that the maximum effect of hydrocortisone in CAH patients is seen 3 hours after a morning dose. After an evening dose, suppression of adrenal hormones continues until approximately 0500 the next day. In both situations, however, there is a large degree of intersubject variability. These data are consistent with earlier published studies. Use of alternate specimen types, possibly in conjunction with delayed release hydrocortisone preparations under development, may allow the practitioner to design a medication regimen that provides improved control of androgen secretion. Whatever dosing strategy is used, clinical judgment is required to ensure the best outcome.
Selective-broadcast optical passive star comer design for dense WDM networks (1991)

A technique is described for design and implementation of an integrated selective-broadcast passive optical star couplers that uses a space-varying refractive index slab. The coupler offers the potential for inexpensive implementation of various routing schemes. It is possible to incorporate a network traffic routing matrix in the design fabric of this bandwidth-selective coupler. The matrix may resemble any desired physical cross connection for routing user traffic. As an example, a shuffle-exchange cross-connect implementation is described. It is shown how this specific routing matrix can be built into the coupler fabric. Such a coupler has application in dense wavelength division multiplexed optical passive star networks where a selective or limited-broadcast coupling capability is desirable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nanosize Particles of ZrVFe Alloy by Pulsed Laser Ablation in Ethanol (2005)

Nanosize powder of ZrVFe alloy has been prepared by a laser ablation method using a ZrVFe alloy as a target material. Ablation of the target alloy was carried out in a liquid container. The laser fluence, energy density at the target surface, was adjusted by manipulating the laser power and focus size to control the ablating conditions. The obtained colloidal dispersions of the nanoparticle were filtered and dried for characterization. The crystal structure of prepared nanoparticles maintained clear crystallinity and was the same as that of the original target alloy by comparison of the X-ray diffraction pattern. The particle sizes were distributed at around 100 nm depending on the used ablation conditions. The minimum average particle size of 71 nm was obtained at the laser fluence of 20.3 J/cm2, while the average size was not proportional to the laser fluence. The morphologies and oxidation state of the particle have been discussed for possible use of the ZrVFe powder as a getter material.
Different Substrate Recognition Motifs of Human and Trypanosome Nucleobase Transporters (2002)

The therapeutic index of antimetabolites such as purine analogues is in large part determined by the extent to which it is selectively accumulated by the target cell. In the current study we have compared the transport of purine nucleobase analogues by the H2 transporter of bloodstream form Trypanosoma brucei brucei and the equilibrative nucleobase transporter of human erythrocytes. The H2 transporter forms hydrogen bonds with hypoxanthine at positions N3, N7, N(1)H, and N(9)H of the purine ring, with apparent Delta G(0) of 7.7-12.6 kJ/mol. The transporter also appears to H-bond with the amine group of adenine. The human transporter forms hydrogen bonds that form to (6)NH(2) and N1 of adenine. An H-bond is also formed with N3 and the 6-keto and amine groups of guanine but not with the protonated N1, thus explaining the low affinity for hypoxanthine. N7 and N9 do not directly interact with the human transporter in the form of H-bonds, and it is proposed that pi-pi stacking interactions contribute significantly to permeant binding. The potential for selective uptake of antimetabolites by the parasite transporter was demonstrated.
A new approach to acoustic beamforming from virtual microphones based on ambisonics for adaptive noise cancelling (2016)

Interference in three-dimensional audio systems is a problematic issue. Eliminating noise, or any other disturbing source, without affecting the spatial audio rendering, is challenging, indeed. Using the least possible number of microphone capsules and reduced size is another issue. An elementary way for accomplishing this job makes use of a 3D audio technique called Ambisonics and a coincident microphone array of 4 elements. This technique allows shaping cardioid-like virtual microphones pointing to a jamming source. This disturbing signal can be used to feed an adaptive noise canceller and kill noise from the 3D recording. Evidently, a 4-capsule array extracts cardioids up to first order. The final result can be improved if microphones with higher directivity are employed. This paper presents a method for deriving highly-directive virtual microphones by means of a 4-capsule ambisonic array and spaced virtual capsules.
Domain vector accelerator (DVA): A query accelerator for relational operations (2002)

A fast method is described for performing relational operations and, in particular, for an equijoin between two relations that stand in a one-to-many relationship. The method is based on a bit-vector technique called domain vector acceleration (DVA). The approach to join acceleration is described and compared analytically with two other join accelerators, hybrid-hash join and join indices. Results show that using domain vectors for simple, binary equijoins between very large tables significantly improves the efficiency of the equijoin operation. Domain vectors also reduce the amount of data that must be cached on disk, relative to join indices and materialized views. DVA can be applied to a wide variety of relational operations, including select, interest, union, semijoin and outer join.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Two decades of high-polymer physics: A survey and forecast (1964)

The twentieth anniversary of the founding of the Division of High-Polymer Physics of the American Physical Society is an appropriate time to review the progress of polymer physics over the last two decades, and to re-evaluate the hopes of the founders and the present need for the Division. The continuing need for our Division perhaps is best shown by the fact that each of the last two meetings have set new records for the number of papers presented. Much of this progress is due to the officers who have contributed so much of their time and effort to the Division. Those who served in the first decade were recognized in an earlier review. The officers of the last decade are shown in the accompanying table. We are indebted to all these men for their work to keep the Division running, and thus promote the progress of polymer physics.
The Full-Wave Voltage-Doubling Rectifier Circuit (1941)

An analysis of the full-wave voltage-doubling rectifier circuit is made in this paper with the main assumption that the tube drop is zero when conducting. Both the output and the input performance characteristics of the circuit are presented, and several of the characteristics are compared with experimental results. The analysis shows that polarized electrolytic condensers may be used if the circuit is not loaded too heavily. The currents to be expected on short circuit are also discussed.
Nanofiber Webs from Electrospinning (2003)

Elecotrospun nanofibers, with fiber diameters of 0.25 microns have been used in industrial, consumer and defense filtration applications for more than twenty years. Electrospun nanofibers have fiber diameters that are 5-10 times smaller than the smallest meltblown fibers available. Recently, Ultra-Web® nanofiber filter media from Donaldson Company has become available to the non-wovens and filtration industries for a broad range of filtration applications. Nanofibers provide dramatic increases in filtration efficiency at relatively small (and in some cases immeasurable) decreases in permeability. In many laboratory tests and actual operating environments, nanofiber filter media also demonstrate improved filter life and more contaminant holding capacity. Nanofiber filter media have enabled new levels of filtration performance in several diverse applications with a broad range of environments and contaminants. The performance of nanofiber media in a mining vehicle cabin air filter will be discussed.
The mapping collector (2008)

Parallel and concurrent garbage collectors are increasingly employed by managed runtime environments (MREs) to maintain scalability, as multi-core architectures and multi-threaded applications become pervasive. Moreover, state-of-the-art MREs commonly implement compaction to eliminate heap fragmentation and enable fast linear object allocation.
CAR, Driving into the Future (2004)

The nuclear orphan receptor CAR is active in the absence of ligand with the unique capability to be further regulated by activators. A number of these activators, including phenobarbital, do not directly bind to the receptor. Considered a xenobiotic sensing receptor, CAR transcriptionally modifies the expression of genes involved in the metabolism and elimination of xenobiotics and steroids in response to these compounds and other cellular metabolites. Its hepatic expression pattern endows the liver with the ability to protect against not only exogenous but also endogenous insults. The mechanism of CAR activation is complex, involving translocation from the cytoplasm to the nucleus in the presence of activators, followed by further activation steps in the nucleus. Although this mechanism remains under investigation, we have summarized here the cellular signaling pathways elucidated so far and speculate on the mechanism by which CAR activators regulate gene expression through this network.
Localizations of targets inside enclosed structures with a single sensor (2011)

In urban sensing and through-the wall radar, the existence of targets in proximity to walls introduces multipath returns. Coherent and noncoherent target localization are typically achieved by using multiple sensors at the expense of system cost, covertness, inflexibility in sensor positioning, and complexity in hardware and processing requirements. In this paper, target localization with a single sensor is achieved by exploiting the target multipath from the walls. A data association algorithm is derived that correctly associates the time-of-arrival (ToA) of the multipath returns to the walls they originate from. This is followed by nonlinear least squares technique to achieve noncoherent target localization. The proposed technique can be used for multiple targets provided that the ToAs of the direct path and multipath returns are all resolvable. Simulations and experimental data are used to validate the proposed algorithms.
Distributed Hierarchical Control of AC Microgrid Operating in Grid-Connected, Islanded and Their Transition Modes (2018)

In this paper, a distributed hierarchical control is proposed for ac microgrid, which could apply to both grid-connected (GC) mode and islanded (IS) mode as well as mode transitions. The control includes three control levels: 1) the basic droop control is adopted as the primary control; 2) the secondary control is based on the distributed control with a leaderâĂ"follower consensus protocol; and 3) the tertiary level is a mode-supervisory control, which manages the different control targets of four operation modes. Under the proposed control framework, the following targets are achieved: 1) the frequency/voltage recovery and accurate power sharing in IS mode; 2) flexible power flow regulation between utility-grid and microgrid in GC mode; 3) universal control strategy from GC to IS modes without control switching; and 4) smooth active-synchronization from IS mode to GC mode. In this sense, the proposed method can adapt to all four operation modes of microgrid. Compared with central-standard hierarchical control, the proposed method only requires local neighbor-to-neighbor interaction with a sparse distributed communication network. Thus, the scalability, flexibility, reliability, and robustness are greatly improved in practical application. In addition, stability analysis is added to facilitate the control parameter designs, and substantial simulation cases are provided to validate the control feasibility, link-failure-resiliency, and plug-and-play capability.
Aluminum Composite Cathodes A New Method for the Fabrication of Efficient and Bright Organic Light-emitting Devices (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. E. Jabbour, S. E. Shaheen, M. M. Morrell, B. Kippelen, N. R. Armstrong, and N. Peyghambarian, "Aluminum Composite Cathodes A New Method for the Fabrication of Efficient and Bright Organic Light-emitting Devices," Optics & Photonics News 10(4), 24-27 (1999) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Optimized InfiniBand<sup>TM</sup>fat‐tree routing for shift all‐to‐all communication patterns (2009)

Abstract Clustered systems have become a dominant architecture of scalable high‐performance super computers. In these large‐scale computers, the network performance and scalability is as critical as the compute‐nodes speed. InfiniBand TM has become a commodity networking solution supporting the stringent latency, bandwidth and scalability requirements of these clusters. The network performance is also affected by its topology, packet routing and the communication patterns the distributed application exercises. Fat‐trees are the topology structures used for constructing most large clusters as they are scalable, maintain cross‐bisectional‐bandwidth (CBB), and are practical to build using fixed‐arity switches. In this paper, we propose a fat‐tree routing algorithm that provides a congestion‐free, all‐to‐all shift pattern leveraging on the InfiniBand TM static routing capability. The algorithm supports partially populated fat‐trees built with switches of arbitrary number of ports and CBB ratios. To evaluate the proposed algorithm, detailed switch and host simulation models were developed and multiple fabric topologies were run. The results of these simulations as well as measurements on real clusters show an improvement in all‐to‐all delay by avoiding congestion on the fabric. Copyright © 2009 John Wiley & Sons, Ltd.
Versatile gas gun target assembly for studying blast wave mitigation in materials (2012)

Traumatic brain injury (TBI) has become a serious problem for military personnel returning from recent conflicts. This has increased interest in investigating blast mitigating materials for use in helmets. In this paper we describe a new versatile target assembly that is used with an existing gas gun for studying these materials.
Abstract 950: In vivo efficacy and pharmacodynamic modulation of JNJ-64619178, a selective PRMT5 inhibitor, in human lung and hematologic preclinical models (2019)

Protein arginine methyltransferase 5 (PRMT5), a type II methyltransferase, is responsible for symmetric arginine di-methylation of multiple cellular proteins involved in the regulation of cellular transcription. PRMT5 is involved in cellular processes such as survival, proliferation, and apoptosis, and an elevated tumor PRMT5 protein level has recently been correlated with poor survival of cancer patients.JNJ-64619178, a selective PRMT5 inhibitor, showed inhibition of cellular growth in several cell lines representing multiple cancer histologies in vitro. From this, a broad selection of xenograft models was chosen to demonstrate potent anti-tumor efficacy.Xenograft models representing small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), acute myeloid leukemia (AML), and non-Hodgkin lymphoma were chosen to demonstrate anti-tumor efficacy. Biologically significant tumor growth inhibition up to 99% was observed in both solid and hematological xenograft models, including an aggressive disseminated model of AML, with oral doses of 1 to 10 mg/kg, once daily. Importantly, continued inhibition of tumor growth was observed for several weeks following dosing cessation.Dosing of JNJ-64619178 results in inhibition of Sym-Arg di-methylation of SMD1/3 proteins, core components of the spliceosome in the tumor, and general Sym-Arg di-methylation of serum proteins. These serve as pharmacodynamic markers of PRMT5 inhibition in xenograft models. Potent and prolonged inhibition of SMD1/3 di-methylation was observed in the SCLC model, during and after the dosing period. This has led to the exploration of alternative dosing regimens preclinically.PRMT5 inhibitor JNJ-64619178 is currently being investigated in a Phase I clinical trial, based on its high selectivity and potency, favorable pharmacokinetics and safety properties, and strong preclinical efficacy and pharmacodynamic data.Citation Format: Hillary J. Millar, Dirk Brehmer, Tinne Verhulst, Nahor Haddish-Berhane, Tony Greway, Dana Gaffney, An Boeckx, Erika Van Heerde, Thomas Nys, Joseph Portale, Ulrike Philippar, Tongfei Wu, Sylvie Laquerre, Kathryn Packman. In vivo efficacy and pharmacodynamic modulation of JNJ-64619178, a selective PRMT5 inhibitor, in human lung and hematologic preclinical models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 950.
Long noncoding RNA NEAT1 promotes laryngeal squamous cell cancer through regulating miR-107/CDK6 pathway (2016)

NEAT1 plays an oncogenic role in the tumorigenesis of LSCC and may serve as a potential target for therapeutic intervention.
Techniques for residue-to-analog conversion for residue-encoded digital filters (1978)

Recent papers have reported that the use of residue number coding in digital filters can result in better speed/cost ratios when compared to filters designed with conventional adders and multipliers. This paper presents two approaches to the design of residue-to-analog converters to be used with residue number filters. The first approach, based on the associated mixed radix number system, is particularly useful when it is desired to translate the residue samples directly into analog form. The second approach, based on the Chinese remainder theorem, is a more direct method for translating from residue to weighted binary representation. A hardware feasibility model is described that was constructed to demonstrate the conversion principles.