gebhart/patrepeval huggingface dataset:
Sequence-Selective Peptide Binding with a Peptido-A,B-<i>trans</i>-steroidal Receptor Selected from an Encoded Combinatorial Receptor Library (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSequence-Selective Peptide Binding with a Peptido-A,B-trans-steroidal Receptor Selected from an Encoded Combinatorial Receptor LibraryYuan Cheng, Toshiro Suenaga, and W. Clark StillView Author Information Department of Chemistry, Columbia University New York, New York 10027 Cite this: J. Am. Chem. Soc. 1996, 118, 7, 1813–1814Publication Date (Web):February 21, 1996Publication History Received28 August 1995Published online21 February 1996Published inissue 1 January 1996https://doi.org/10.1021/ja952976vCopyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views246Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (128 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Binding energy,Conformation,Peptides and proteins,Receptors,Surface interactions Get e-Alerts
Carcinoma oral de células escamosas: visión global de sus aspectos epidemiológicos; etiopatogénicos, clínicos y terapéuticos. (1996)

Presentamos una revision de los aspectos epidemiologicos, etiopatogenicos, asi como en sus caracteristicas clinicas del carcinoma oral de celulas escamosa. A su vez describimos las principales lesiones y condiciones precancerosas de la mucosa bucal.
A hyper-distributed switching system architecture for B-ISDN (2002)

A hyper-distributed switching system architecture is proposed for a large-scale asynchronous transfer mode (ATM) switching system to handle heterogeneous traffic and sophisticated services for B-ISDN. The system consists of a non-intelligent module with small capacity ATM switches allocated separately at a single stage, and many independent modules have call processing. The same architecture from a small-scale system can be used in a large-scale system by connecting the ATM links among the regularly allocated ATM switches. Also proposed are a nonblocking switching configuration, efficient intermodule connection, concentrated quality control, state dependent intermodule routing, and virtual channel assignment to decrease the label conversion table size in the hyper-distributed switching system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Adaptive methods to preserve power amplifier linearity under antenna mismatch conditions (2005)

Under antenna mismatch conditions at high output power, voltage clipping (due to collector voltage saturation) is the main cause of power amplifier linearity degradation. To preserve linearity under mismatch three adaptive methods are presented that make use of the detected minimum collector peak voltage. This detected signal controls either the amplifier output power, load-line, or supply voltage. These concepts are generalized analytically, and calculated results compare well to simulations. Measurements demonstrate am error vector magnitude reduction of 5% and an adjacent channel power ratio improvement of 10 dB at a voltage standing wave ratio of 4 for an EDGE amplifier with adaptively controlled output power. These adaptive methods offer a cost and size effective alternative to the use of an isolator.
Field-frequency locked X-band Overhauser effect spectrometer (1981)

The design and construction of an Overhauser Effect Spectrometer operating at X band is described. The ESR section is a Varian V-4502 spectrometer equipped with a 9-in. electromagnet and a shim coil assembly. NMR detection is based on a broadband rf hybrid juction feeding a coil in an X-band quartz dielectric cavity. Signal processing is carried out at a constant intermediate frequency of 25.1 MHz with a Varian V-4311 fixed frequency rf unit. The mixing scheme employed to translate the NMR information to 25.1 MHz is described. Medium resolution performance (resolution ∼10−6) for the NMR is achieved under field-frequency locked conditions. The lock is based on a Super-Regenerative Oscillator (SRO) housing a control sample, and operating as a field-tracking frequency source. This SRO injects into an oscillator which excites the analytical sample resonance and also serves as a local oscillator, thereby making the locked spectrometer multinuclear in capability. Typical Overhauser effect recordings of protons and fluorines are presented.
Learning the morphology of Zulu with different degrees of supervision (2008)

In this paper we compare different levels of supervision for learning the morphology of the indigenous South African language Zulu. After a preliminary analysis of the Zulu data used for our experiments, we concentrate on supervised, semi-supervised and unsupervised approaches comparing strengths and weaknesses of each method. The challenges we face are limited data availability and data sparsity in connection with morphological analysis of indigenous languages. At the end of the paper we draw conclusions for our future work towards a morphological analyzer for Zulu.
Fast mode decision for multiview video coding (2009)

In the draft of multi-view coding (MVC), variable size motion estimation and disparity estimation are employed to select the best coding mode for each macroblock. These techniques achieve the highest possible coding efficiency, but they result in extremely large computation complexity which obstructs MVC from practical application. This paper proposes a fast mode size decision algorithm for MVC in inter-frame coding. It makes use of the mode distribution correlation between neighbor views to deduct the executions of unnecessary modes. Experimental results show that the proposed fast mode decision algorithm reduces the computational complexity significantly with negligible coding efficiency.
Introduction to Speech Recognition (2013)

About 15 lectures Some lab exercises (Matlab/Octave, HTK, Python/Bash) Some coursework: build an ASR system (worth 30%) An exam in April or May (worth 70%) Books and papers: Jurafsky & Martin (2008), Speech and Language Processing, Pearson Education (2nd edition). (J&M) Some general review and tutorial articles Readings for specific topics If you haven’t taken Speech Processing... — read J&M, chapter 7 (Phonetics)
Characterization of hot wall RTP for thin gate oxide films (2002)

We have developed single-wafer furnace RTP modules for thermal oxidation of silicon substrates. 20 /spl Aring/ dry oxide films were grown on 200 mm diameter Si wafers at 950/spl deg/C with within-wafer uniformity below 0.6% and wafer-to-wafer uniformity 0.5% (1/spl sigma/ standard deviation, 49 points with 1.5 mm edge exclusion) for 10 successive runs. Wet oxidation at 850/spl deg/C provides 25 /spl Aring/ oxide films with uniformity below 0.8% (1/spl sigma/). Thermal nitridation in nitric oxide (NO) and reoxidation can provide sub 25 /spl Aring/ oxides. For a 25 wafer repeatability experiment using 300 mm wafers, the average within wafer standard deviation of the thickness for a 20 /spl Aring/ gate oxide was 0.5% (1/spl sigma/, 49 points with 3 mm edge exclusion). The thermal stress within the silicon wafer is maintained at low levels shown with both in-situ thermal data and from post-process inspection. It is demonstrated that thin gate oxide films can be generated without the drawbacks associated with lamp based systems.
SYNTHESIS OF 1,2-PROPANEDIOL FORMATES FROM CARBON DIOXIDE, HYDROGEN, AND METHYLOXIRANE CATALYZED BY TRANSITION METAL COMPLEX (1977)

Abstract Glycol formates were prepared in a new type of catalytic reaction using carbon dioxide, hydrogen, and an oxirane as direct starting materials, and a transition metal complex like tris(triphenylphosphine)chlororhodium as catalyst.
An Insecticidal N-Acetylglucosamine-Specific Lectin Gene from Griffonia simplicifolia (Leguminosae) (1996)

Griffonia simplicifolia II, an N-acetylglucosamine-specific legume lectin, has insecticidal activity when fed to the cowpea weevil, Callosobruchus maculatus (F.). A cDNA clone encoding G. simplicifolia II was isolated from a leaf cDNA library, sequenced, and expressed in a bacterial expression system. The recombinant protein exhibited N-acetylglucosamine-binding and insecticidal activity against cowpea weevil, indicating that glycosylation and multimeric structure are not required for these properties. These results support the hypothesis that genes of the legume lectin gene family encode proteins that function in plant defense against herbivores.
Abasic Sites in DNA of HeLa Cells Induced by Lucanthone (2002)

Abasic sites in HeLa cell DNA were increased in frequency by exposing the cells to lucanthone. Cell growth in the presence of lucanthone caused progressive accumulation of abasic sites and loss of cellular DNA. After 2 hr in 8 microM lucanthone, the abundance of abasic sites was 2.4 fold greater than the background of 9.9 +/- 2.0 SE abasic sites/10(6) nucleotides; 80 microM lucanthone in the growth medium increased the level 12.6 +/- 2.5 SE fold and decreased the DNA content in HeLa cells to one-half of the value obtained in untreated cells. The frequency of abasic sites in cellular DNA was determined by the aldehyde reactive probe method, with reference to abasic sites created in plasmid pBR322. The ability of lucanthone to inhibit the normal repair of abasic sites might reflect inhibition of apurinic/apyrimidinic endonuclease (HAP1) by the drug, thereby preventing an early step in the base excision repair pathway. Unrepaired abasic sites prevalent after ionizing radiation are cytotoxic lesions that promote DNA strand breaks. These results suggest a rationale for the joint lethal effects of lucanthone and ionizing radiation in cells and the accelerated tumor regression observed in cancer patients who received the combined therapy.
Overexpression of microRNA‐122 enhances in vitro hepatic differentiation of fetal liver‐derived stem/progenitor cells (2013)

MicroRNAs (miRNAs) are a versatile class of tiny non-coding RNAs involved in regulation of various biological processes. miRNA-122 (miR-122) is specifically and abundantly expressed in human liver. However, the role of miR-122 in differentiation of fetal liver stem/progenitor cells into hepatocytes remains unclear. In this study, dual positive CD34+/CD117+ expressing human fetal liver stem/progenitor cells was enriched by magnetic cell sorting and cultured in vitro. The level of miR-122 was found to be increased at specific time intervals. Interestingly, during the differentiation process of hepatocyte-like cells, the increase in expression of miR-122 was positively correlated with expression of hepatocyte-specific genes. The status of differentiation process was improved by transfection of miR-122 into enriched stem/progenitor cells. The expression level of hepatic-specific genes as well as liver-enriched transcription factors (LETFs) was significantly increased by overexpression of miR-122 in fetal liver stem/progenitor cells. Thus, the study delineated the role of hepato-specific miR-122 in differentiation of fetal liver stem/progenitor cells into hepatocyte-like cells which could be used as a therapeutic target molecule to generate abundant hepatocytes.
Neutralization of Hepatitis B Virus Infectivity by a Murine Monoclonal Antibody: An Experimental Study in the Chimpanzee (1985)

Two study chimpanzees were inoculated intravenously with approximately 1,000 chimpanzee infectious doses of hepatitis B virus (HBV), one with subtype adr and one with subtype ayw, each previously incubated with 0.1 ml of a murine monoclonal antibody (IgG 1(K) class) directed against a single epitope on hepatitis B surface antigen common to most or all HBV. Two control chimpanzees received identical doses of HBV not incubated with the murine anti-HBs. Neither study chimpanzee developed HBV infection during 12 months of follow-up as judged by normal serum aminotransferase activity, normal liver biopsies, and negative serological tests for HBV-associated antigens and antibodies. In contrast, both control chimpanzees became infected by HBV as evidenced by elevated serum aminotransferase activity, liver biopsy changes characteristic of viral hepatitis, and the appearance of hepatitis B surface antigen (HBsAg) in their sera. Both study chimpanzees were shown to be fully susceptible to infection with these same HBV inocula when challenged 15 months after the initial inoculations at a time when passively administered anti-HBs was no longer detectable. Prior to challenge with HBV, one of the two study chimpanzees received a second injection of the same volume of the murine monoclonal anti-HBs. The survival of this anti-HBs in serum was reduced from six weeks (after the initial injection) to approximately two weeks.(ABSTRACT TRUNCATED AT 250 WORDS)
Lightning protection of wind turbines &#x2014; A comparison of lightning data &#x00026; IEC 61400-24 (2009)

IEC 61400-24 dealing with lightning protection of wind turbines was first introduced in 2002. This was initially developed as a technical report. Since then, wind power has been rapidly developing with wind turbine manufacturers developing larger wind turbines which are at an increased risk of lightning strikes. With the move of large wind farms offshore, maintenance of wind turbines also becomes harder owing to the harsh and unpredictable environment. Limiting lightning strike damage on wind turbines becomes even more important. The IEC technical report has recently been developed into a full standard by the committee. The test levels (at which components should be tested) stated in the standard are based on those presented in IEC 62035 - Protection against Lightning. The present paper discusses the relevancy of the test levels in comparison to actual lightning strike data gathered from different wind farms of the world.
Depolymerization of Lignin with Supercritical Fluids: A Review (2013)

Biomass has attracted keen interest as a renewable resource and an environmental friendly material that is essential to realize a sustainable world. Lignin as biomass has been long labeled with waste material. But now the innate chemistry of lignin and a phenolic heteropolymer, has allowed it to make inroads into the high value polymer and natural biomass material industries. Supercritical fluids (SCF) have been shown to be a promising technique for future large-scale biofuel and base-chemicals production, especially for depolymerization production from lignin. This paper reviews the research progress of lignin-depolymerization processes, including effects of process parameters, such as reaction time, temperature, pressure and catalyst, product analysis, and reaction mechanism with different supercritical fluids. The problems of depolymerization with supercritical fluid technology and its development direction are also briefly discussed. Compared with conventional lignin production methods, the SCF technology processes of lignin can produce smaller fragments through breakage of the ether linkages and produce larger fragments through cross linking between the reactive fragments, and the depolymerization lignin processes are typically conducted at mild operating conditions, and the monomeric products have a high economic value because the aromatic products can be readily blended into current transportation fuels or used in chemical industry.
Style mining of electronic messages for multiple authorship discrimination (2003)

This paper considers the use of computational stylistics for performing authorship attribution of electronic messages, addressing categorization problems with as many as 20 different classes (authors). Effective stylistic characterization of text is potentially useful for a variety of tasks, as language style contains cues regarding the authorship, purpose, and mood of the text, all of which would be useful adjuncts to information retrieval or knowledge-management tasks. We focus here on the problem of determining the author of an anonymous message, based only on the message text. Several multiclass variants of the Winnow algorithm were applied to a vector representation of the message texts to learn models for discriminating different authors. We present results comparing the classification accuracy of the different approaches. The results show that stylistic models can be accurately learned to determine an author's identity.
Superalloys, supercomposites and superceramics (1989)

The present work covers the development history of superalloys, the supply status and availability of strategic materials associated with superalloy compositions, primary and secondary melt processing for superalloys, the metallurgy of investment-cast superalloy components, the nature and properties of single-crystal superalloys, the thermomechanical processing of superalloys, and the effects of alloying compositions on hot deformation. Also discussed are the powder metallurgy and oxide dispersion processing of superalloys, the character of oxide dispersion-strengthened alloys, creep-fatigue property interactions in structural alloys, long-term creep and stress rupture, cyclic deformation and fatigue-crack propagation in Ni-base alloys, life-prediction and fatigue, high-temperature corrosion, hydrogen embrittlement in rocket engines, refractory element-strengthening in gamma-prime and gamma-double-prime precipitation-hardened Ni-base superalloys, fiber-reinforced superalloys, the high-temperature performance of ceramic composites, and the characteristics of several carbon/carbon composite systems.
Weight loss in obese subjects on a restricted diet given BRL 26830A, a new atypical   adrenoceptor agonist (1988)

A double blind placebo controlled study was carried out in 40 subjects newly referred for treatment for obesity to determine the effects of the new thermogenic beta adrenoceptor agonist BRL 26830A. The subjects were randomised to receive either BRL 26830A, 200 mg daily for two weeks then 400 mg daily, or placebo for 18 weeks, and all were instructed to follow a 3.35 MJ diet that was low in fat and high in fibre. Weight loss was 15.4 (SD 6.6) kg in subjects given BRL 26830A compared with 10.0 (5.9) kg in those given placebo (p = 0.02). The relative weight loss was 0.93 (0.39%) a week with BRL 26830A and 0.61 (0.38)% with placebo (p = 0.02). Urinary excretion of nitrogen was similar in both groups, whereas measurements of skinfold thickness indicated a 4.1 kg difference in the amount of fat lost, suggesting that weight loss with BRL 26830A was mainly from adipose and not lean tissue. BRL 26830A had no effect on resting pulse rate or pressor effects on either diastolic or systolic blood pressure. No significant differences were found between the two groups in serum cholesterol concentration, percentage of high density lipoprotein cholesterol, plasma concentrations of glucose and insulin, the ratio of glucose to insulin, serum concentrations of triiodothyronine and thyroxine, and creatinine clearance. Short term administration of BRL 26830A to six subjects who had taken the drug for 18 weeks showed that the expenditure of energy increased by 11.6% during the second hour after administration, which suggests that BRL 26830A may enhance weight loss thermogenically. BRL 26830A may be a useful drug in the treatment of obesity.
The Impact of Personalization on Smartphone-Based Activity Recognition (2012)

Smartphones incorporate many diverse and powerful sensors, which creates exciting new opportunities for data mining and human-computer interaction. In this paper we show how standard classification algorithms can use labeled smartphone-based accelerometer data to identify the physical activity a user is performing. Our main focus is on evaluating the relative performance of impersonal and personal activity recognition models. Our impersonal (i.e., universal) models are built using training data from a panel of users and are then applied to new users, while our personal models are built with data from each user and then applied only to new data from that user. Our results indicate that the personal models perform dramatically better than the impersonal models—even when trained from only a few minutes worth of data. These personal models typically even outperform hybrid models that utilize both personal and impersonal data. These results strongly argue for the construction of personal models whenever possible. Our research means that we can unobtrusively gain useful knowledge about the habits of potentially millions of users. It also means that we can facilitate human computer interaction by enabling the smartphone to consider context and this can lead to new and more effective applications.
Structure analysis of the endoxylanase A gene from Penicillium purpurogenum (2001)

Penicillium purpurogenum produces several endoxylanases, two of which (XynA and XynB) have been purified and characterized. XynB has been sequenced, and it belongs to glycosyl hydrolase family 11. In this publication we report the structure of the xynA gene. The amino terminal sequence of the protein was determined and this allowed the design of oligonucleotides for use in polymerase chain reactions. Different polymerase chain reaction strategies were used to amplify and sequence the entire cDNA and the gene. The gene has an open reading frame of 1450 base pairs, including 8 introns with an average length of 56 base pairs each. Only one copy of this gene is present in the P. purpurogenum genome as shown by Southern blot. The gene encodes a protein of 329 residues (including the signal peptide), and the calculated molecular mass of the mature protein is 31,668 Da. Immunodetection assays of the expressed gene positively identified it as xynA, and sequence alignments indicate a high degree of similarity with family 10 endoxylanases. It is concluded that P. purpurogenum produces endoxylanases of family 10 and 11. The complementary action of endoxylanases of both families may be important for an efficient degradation of xylan by the fungus.
Molecular evolution of the fungi: relationship of the Basidiomycetes, Ascomycetes, and Chytridiomycetes. (1992)

Establishing the phylogeny of fungi and protists often has proved difficult owing to the simple morphologies and convergent characters in these organisms. We used DNA sequences of nuclear small-subunit ribosomal RNA genes to determine phylogenetic relationships among three major classes of organisms considered to be fungi--Basidiomycetes, Ascomycetes and Chytridiomycetes--and to assess the taxonomic position of Neocallimastix, an economically important anaerobic rumen microorganism whose classification is controversial. The Basidiomycetes and Ascomycetes, two classes of nonflagellated fungi, are the most closely related taxa. Chytridiomycetes, though bearing flagella, group with these higher fungi rather than with the protists. Neocallimastix, a eukaryote lacking mitochondria and variously classified as a protist or as a fungus, shows closest molecular affinities with the Chytridiomycete fungi in the order Spizellomycetales.