gebhart/patrepeval huggingface dataset:
Protection coordination for dual failure on two-layer networks (2015)

Network layers such as IP/MPLS and OTN/ASON each has its own failure protection scheme. We propose a coordinated protection plan, so called protection synergy, to protect all possible dual failures by utilizing existing single failure protection schemes. There are two aspects essential for effective dual failure protection: One is to guarantee the connectivity under any dual fiber failures, the other is to allocate minimum but enough spare capacity on both layers. Our model achieves both goals using a novel topology mapping technique and computing working and backup paths with an accurate path disjoint criterion. The experimental results on four networks demonstrate complete dual failure restorability and spare capacity savings of the protection synergy approach.
Genotype-phenotype relationship in hereditary haemorrhagic telangiectasia (2005)

Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterised by vascular malformations in multiple organ systems, resulting in mucocutaneous telangiectases and arteriovenous malformations predominantly in the lungs (pulmonary arteriovenous malformation; PAVM), brain (cerebral arteriovenous malformation; CAVM), and liver (hepatic arteriovenous malformation; HAVM). Mutations in the ENG and ALK-1 genes lead to HHT1 and HHT2 respectively. In this study, a genotype-phenotype analysis was performed. A uniform and well classified large group of HHT patients and their family members were screened for HHT manifestations. Groups of patients with a clinically confirmed diagnosis and/or genetically established diagnosis (HHT1 or HHT2) were compared. The frequency of PAVM, CAVM, HAVM, and gastrointestinal telangiectases were determined to establish the genotype-phenotype relationship. The analysis revealed differences between HHT1 and HHT2 and within HHT1 and HHT2 between men and women. PAVMs and CAVMs occur more often in HHT1, whereas HAVMs are more frequent in HHT2. Furthermore, there is a higher prevalence of PAVM in women compared with men in HHT1. In HHT1 and HHT2, there is a higher frequency of HAVM in women. HHT1 has a distinct, more severe phenotype than HHT2. There is a difference in the presence of symptoms between men and women. With these data, genetic counselling can be given more accurately when the family mutation is known.
New MRI method with contrast based on the macromolecular characteristics of tissues (2003)

A new MRI method with a contrast that is derived from the macromolecular composition and spin dynamics in the tissue is described and demonstrated on excised mouse brain and rat spinal cord. In the method, magnetization is selectively excited in the macromolecules by using a double quantum filter and subsequently transferred to water. The new imaging method differs from previous methods that rely on magnetization transfer contrast (MTC) in that it enables a separate and independent control of the effect of the macromolecule characteristics, chemical exchange, and water-related parameters on the images.
Estradiol Rapidly Activates Akt via the ErbB2 Signaling Pathway (2003)

Previously, we have demonstrated that the two mitogenic growth factors epidermal growth factor and IGF-I can activate Akt and estrogen receptor-alpha (ERalpha) in the hormone-dependent breast cancer cell line, MCF-7. In this report we now show that estradiol can also rapidly activate phosphatidylinositol 3-kinase (PI 3-K)/Akt and that this effect is mediated by the ErbB2 signaling pathway. Treatment of cells with estradiol resulted in phosphorylation of Akt and a 9-fold increase in Akt activity in 10 min. Akt activation was blocked by wortmannin and LY 294,002, two inhibitors of PI 3-K; by genistein, a protein tyrosine kinase inhibitor and an ER agonist; by AG825, a selective ErbB2 inhibitor; and by the antiestrogens ICI 182,780 and 4-hydroxy-tamoxifen; but not by rapamycin, an inhibitor of the ribosomal protein kinase p70S6K; nor by AG30, a selective epidermal growth factor receptor inhibitor. Akt activation by estradiol was abrogated by an arginine-to-cysteine mutation in the pleckstrin homology domain of Akt (R25C). Growth factors also activated Akt in the ER-negative variant of MCF-7, MCF-7/ADR, but estradiol did not induce Akt activity in these cells. Transient transfection of ERalpha into these cells restored Akt activation by estradiol, suggesting that estradiol activation of Akt requires the ERalpha. Estradiol did not activate Akt in MCF-7 cells stably transfected with an anti-ErbB2-targeted ribozyme, further confirming a role for ErbB2. In vitro kinase assays using immunoprecipitation and anti-Akt1, -Akt2, and -Akt3-specific antibodies demonstrated that Akt1 is activated by estradiol in MCF-7 cells whereas Akt3 is the activated isoform in ER-negative MDA-MB231 cells, implying that selective activation of Akt subtypes plays a role in the actions of estradiol. Taken together, our data suggest that estradiol, bound to membrane ERalpha, interacts with and activates an ErbB dimer containing ErbB2, inducing activation of PI 3-K/Akt.
Trust-Based Service Management for Social Internet of Things Systems (2015)

A social internet of things (IoT) system can be viewed as a mix of traditional peer-to-peer networks and social networks, where “things” autonomously establish social relationships according to the owners' social networks, and seek trusted “things” that can provide services needed when they come into contact with each other opportunistically. We propose and analyze the design notion of adaptive trust management for social IoT systems in which social relationships evolve dynamically among the owners of IoT devices. We reveal the design tradeoff between trust convergence versus trust fluctuation in our adaptive trust management protocol design. With our adaptive trust management protocol, a social IoT application can adaptively choose the best trust parameter settings in response to changing IoT social conditions such that not only trust assessment is accurate but also the application performance is maximized. We propose a table-lookup method to apply the analysis results dynamically and demonstrate the feasibility of our proposed adaptive trust management scheme with two real-world social IoT service composition applications.
An End-to-End System for Unconstrained Face Verification with Deep Convolutional Neural Networks (2015)

In this paper, we present an end-to-end system for the unconstrained face verification problem based on deep convolutional neural networks (DCNN). The end-to-end system consists of three modules for face detection, alignment and verification and is evaluated using the newly released IARPA Janus Benchmark A (IJB-A) dataset and its extended version Janus Challenging set 2 (JANUS CS2) dataset. The IJB-A and CS2 datasets include real-world unconstrained faces of 500 subjects with significant pose and illumination variations which are much harder than the Labeled Faces in the Wild (LFW) and Youtube Face (YTF) datasets. Results of experimental evaluations for the proposed system on the IJB-A dataset are provided.
The Measurement of Particle Size Distribution of Al<SUB>2</SUB>O<SUB>3</SUB> Inclusion in Ultra Low Oxygen Steel (1991)

A technique for particle size distribution measurement of Al2O3 inclusion in ultra low oxygen steel by combination of ultrasonic classification method and centrifugal sedimentation photo-extinction method has been established.The procedure is as follows.(1) The Al2O3 inclusion extracted from steel by acid decomposition is classified at over and under 5μm with ultrasonic filtration.(2)The Al2O3 inclusion over 5μm is weighed.(3) The particle size distribution of Al2O3 inclusion under 5μm is measured automatically with centrifugal sedimentation photo-extinction method.(4)The particle size distribution of Al2O3 in steel can be obtained by using from (1) to (3).This technique makes it possible to measure particle size distribution of Al2O3 to sub-micron order, and gives instructive information about coalescence and/or floating behavior of Al203 inclusion during refining prosess.
Effects of diaphragm shortening on the mean action potential conduction velocity in canines. (1996)

1. The present study was designed to test if the mean muscle fibre action potential conduction velocity (VAPC) in the costal diaphragm changes with muscle length, in spontaneously breathing mongrel dogs. 2. VAPC was determined by the electromyogram (EMG) power spectrum 'dip' method, which is based on the bipolar electrode transfer function. A bipolar EMG electrode with a 20 mm fixed interelectrode distance was sutured to the costal diaphragm in the fibre direction, and in a region with a low density of motor endplates. Diaphragm length was measured with piezoelectric crystals positioned next to the EMG electrode. Seven dogs were vagotomized and spinally anaesthetized in order to increase diaphragmatic shortening, reduce velocity of shortening and abolish possible cross-talk signals from adjacent muscles. 3. Our results showed that VAPC in the canine costal diaphragm was 3.4 m s-1 and was not significantly related to diaphragmatic shortening.
A new method for calculating one-dimensional process margin in consideration of process variations (2003)

Yield and device characteristics in VLSI become more sensitive to process variations with finer patterns and enlargement of wafer size. Thus, process integration should take account of the inter- and intra-wafer process variations for elimination of yield loss. However, it is difficult to perform experiments which cover possible process variations because of cost and time. In this paper, we describe a new method for calculating a process margin for processes such as etching and deposition with consideration of process variations using the Monte Carlo method.
<title>Boeing Shaped Scan Correlator (BOSSCO)</title> (1980)

The optical area correlation system developed by The Boeing Company for missile terminal guidance is called BOSSCO. This development was partially funded under the Air Force Armament Laboratories (AFATL), Eglin AFB, Florida, which sponsored the Pavestorm III program as a highly accurate clear-weather weapon for stationary targets. This paper describes the system design, hardware design and test program conducted during the period of the contract (1972-1974). Also described is the redesign and retest effort conducted under independent research funding to correct design errors and reach the present performance level. Alternate applications including navigation update, map matching and image correlation or alignment were later explored both independently and under contract with the Engineering Topographical Laboratories (ETL), Fort Belvoir, Virginia. Further flight testing and laboratory demonstrations took place over Fort Belvoir and at the Army Missile Command (MICOM), Huntsville, Alabama. This system represents a unique capability which, when mechanized in large scale integrated circuit technology, could significantly increase our national defense capability by providing a near-term fire-and-forget guidance option.
Journal of Translational Medicine reviewer acknowledgement 2015 (2016)

© 2016 Marincola. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Reviewer acknowledgement
Effect of Surface Roughness and Electrostatic Surface Potentials on Forces Between Dissimilar Surfaces in Aqueous Solution (2011)

The first surface force measurements under electrochemical potential control between a metal and a ceramic surface across a liquid medium (water) are reported. Our experiments also investigate and reveal how increasing levels of surface roughness and dissimilarity between the potentials of the interacting surfaces influence the strength and range of electric double layer, van der Waals, hydration, and steric forces and how this contributes to deviations from DLVO theory at small distances within aqueous solution.
Design and VLSI Implementation of Pipelined Multiply Accumulate Unit (2009)

In the majority of the Digital signal processing (DSP) applications, the critical operations usually involve many multiplications and /or accumulations. So, for real time signal processing applications, high throughput multiplier -accumulator (MAC) is always a key element to achieve a high-performance digital signal processing application. In the last few years, the main consideration of MAC design is to enhance its speed. This is because speed and throughput rate are always the concerns of digital signal processing systems. However due to the increase of portable electronic products, low power designs also become another major consideration. This is because, the limited battery energy of these portable products restricts the power consumption of the system. Therefore the main motivation is to investigate various pipelined MAC architectures and circuit and the design techniques which are suitable for the implementation of high through put signal processing algorithms. The goal of this project was to design and VLSI implementation of pipelined MAC for high-speed DSP applications at 180nm technology. For designing the pipelined MAC, various architectures of multipliers and one bit full adders are considered. The static and dynamic one bit full adder was implemented as the basic block. For checking the functionality of the whole system, spice code is written using the HSPICE by defining all the blocks in the circuit as the sub circuits. Then a schematic capture is done using schematic composer from virtuoso starting from bottom level to top level. Finally the layout for the complete MAC is done using virtuoso.
Binding and neutralization characteristics of a panel of monoclonal antibodies to human papillomavirus 58 (2010)

Human papillomavirus (HPV) 58 is a high-risk HPV type associated with progression to invasive genital carcinomas. We developed six monoclonal antibodies (mAbs) against HPV58 L1 virus-like particles that bind conformational epitopes on HPV58. The hybridoma cell lines were adapted to serum- and animal component-free conditions and the mAb supernatants were affinity-purified. The six mAbs neutralized HPV58 pseudoviruses (PsVs) and 'quasivirions' with different capacities. The mAbs differed in their ability to prevent PsV58 attachment to HaCaT cells, to the extracellular matrix (ECM) deposited by HaCaT cells, to heparin and to purified human laminin 5, a protein in the ECM. These mAbs provide a unique set of tools to study the binding properties of a previously untested, high-risk HPV type and the opportunity to compare these characteristics with the binding of other HPV types.
Looking for patterns (2007)

One of the desirable outcomes in mathematics is ‘the ability to recognize and recreate patterns’. It is one of the important aspects of mathematical understanding which help to provide the foundations for numeracy. We can help to develop this understanding by encouraging children to look for patterns in their surroundings and by giving them the opportunities to copy and create patterns of their own through practical activities.
The complete genome sequence of<i>Mycobacterium avium</i>subspecies<i>paratuberculosis</i> (2005)

We describe here the complete genome sequence of a common clone of Mycobacterium avium subspecies paratuberculosis (Map) strain K-10, the causative agent of Johne's disease in cattle and other ruminants. The K-10 genome is a single circular chromosome of 4,829,781 base pairs and encodes 4,350 predicted ORFs, 45 tRNAs, and one rRNA operon. In silico analysis identified >3,000 genes with homologs to the human pathogen, M. tuberculosis (Mtb), and 161 unique genomic regions that encode 39 previously unknown Map genes. Analysis of nucleotide substitution rates with Mtb homologs suggest overall strong selection for a vast majority of these shared mycobacterial genes, with only 68 ORFs with a synonymous to nonsynonymous substitution ratio of >2. Comparative sequence analysis reveals several noteworthy features of the K-10 genome including: a relative paucity of the PE/PPE family of sequences that are implicated as virulence factors and known to be immunostimulatory during Mtb infection; truncation in the EntE domain of a salicyl-AMP ligase (MbtA), the first gene in the mycobactin biosynthesis gene cluster, providing a possible explanation for mycobactin dependence of Map; and Map-specific sequences that are likely to serve as potential targets for sensitive and specific molecular and immunologic diagnostic tests. Taken together, the availability of the complete genome sequence offers a foundation for the study of the genetic basis for virulence and physiology in Map and enables the development of new generations of diagnostic tests for bovine Johne's disease.
Reduced-Complexity MIMO Detection via a Slicing Breadth-First Tree Search (2017)

A bottleneck in multiple-input multiple-output communications systems is the complexity of detection at the receiver. The complexity of optimum maximum-likelihood detection is often prohibitive, especially for large numbers of antennas and large alphabets. A suboptimal tree-search-based detector known as the K-best detector is an effective scheme that provides a flexible performance-complexity tradeoff. In this paper, we identify scalar list detection as a key building block of the K-best detector, and we propose an efficient low-complexity implementation of the scalar list detector for M-ary QAM using a slicing operation. Embedding the slicing list detector into the K-best framework leads to our proposed slicing K-best detector. Simulation results show that the proposed detector offers comparable performance to the conventional K-best detector, but with significantly reduced complexity when K is less than the QAM alphabet size M. Since the slicing list detection is performed at each visited node in the detection tree, the complexity reduction is especially significant when the number of antennas and the alphabet size are large, making the proposed detector a competitive option for high spectral-efficiency wireless systems.
Effect of body mass index and device type on infection in left ventricular assist device support beyond 30 days (2010)

Infection as a complication of long-term left ventricular assist device (LVAD) support leads to significant morbidity and mortality. Obesity, a possible risk factor for other postoperative cardiovascular surgical site infections, is an increasingly prevalent condition among recipients of LVAD devices. We retrospectively analyzed 145 LVADs that remained in place beyond 30 days over a nine-year period at a single medical institution. Statistical analysis was carried out using univariate and multivariable logistic regression and chi(2)-testing where indicated. Body mass index (BMI) had no effect on the incidence of infectious outcomes regardless of age, gender, underlying pathogen or device type. This included the morbidly obese population as well (BMI >or=40). Independent of BMI, device type did have an effect, with the HeartMate XVE increasing the risk for infections [odds ratio (OR) 4.3 with 95% confidence interval (CI) 2.1-8.8, P=0.0001] and the HeartMate II reducing the risk (OR 0.21 with 95% CI 0.09-0.50, P=0.0001). The risk for infection after LVAD placement for long-term support is likely to be a multi-factorial phenomenon. BMI, including morbid obesity, does not appear to be a statistically significant relevant factor in determining that risk. Device type may have an effect, however, on risk of infection in long-term support.
Enabling NFC Technology to Public Services (2009)

Ambient Intelligent are usually emerged in contexts like health, education, business and so on. However there are not many researches focusing on social aspects as public administrations. In these kinds of contexts, some problems are continuously in our minds. Especially these that people waste time on clues or solving dubs about the required documents. In this work we present a proposal through the adaptability of the Near Field Communication technology (NFC). With it, some tags and readers can interact with the mobile phones, running different applications according to the places, contexts and users' requirements.
ZFC3H1, a Zinc Finger Protein, Modulates IL-8 Transcription by Binding with Celastramycin A, a Potential Immune Suppressor (2014)

Celastramycin A, a small molecule that inhibits the production of antibacterial peptides in an ex vivo culture system of Drosophila, suppresses the TNFα-mediated induction of IL-8 in mammalian cells. To understand its molecular mechanism, we examined Celastramycin A binding proteins and investigated their biological functions. Our screening and subsequent pull-down assay revealed ZFC3H1 (also known as CCDC131 or CSRC2), an uncharacterized zinc finger protein, as a Celastramycin A binding protein. The knockdown of ZFC3H1 reduced IL-8 expression levels in the TNFα-stimulated lung carcinoma cell line, LU99, and UV-irradiated HeLa cells. Based on reporter assay results, we concluded that ZFC3H1 participates in the transcriptional activation of IL-8. The findings of our UV-irradiation experiments implied that ZFC3H1 may indirectly interact with ERCC1 in an activated DNA repair complex. Thus, we designated ZFC3H1 as a mammalian target of Celastramycin A (mTOC).
Functional interactions between the LRP6 WNT co-receptor and folate supplementation (2010)

Crooked tail (Cd) mice bear a gain-of-function mutation in Lrp6, a co-receptor for canonical WNT signaling, and are a model of neural tube defects (NTDs), preventable with dietary folic acid (FA) supplementation. Whether the FA response reflects a direct influence of FA on LRP6 function was tested with prenatal supplementation in LRP6-deficient embryos. The enriched FA (10 ppm) diet reduced the occurrence of birth defects among all litters compared with the control (2 ppm FA) diet, but did so by increasing early lethality of Lrp6(-/-) embryos while actually increasing NTDs among nulls alive at embryonic days 10-13 (E10-13). Proliferation in cranial neural folds was reduced in homozygous Lrp6(-/-) mutants versus wild-type embryos at E10, and FA supplementation increased proliferation in wild-type but not mutant neuroepithelia. Canonical WNT activity was reduced in LRP6-deficient midbrain-hindbrain at E9.5, demonstrated in vivo by a TCF/LEF-reporter transgene. FA levels in media modulated the canonical WNT response in NIH3T3 cells, suggesting that although FA was required for optimal WNT signaling, even modest FA elevations attenuated LRP5/6-dependent canonical WNT responses. Gene expression analysis in embryos and adults showed striking interactions between targeted Lrp6 deficiency and FA supplementation, especially for mitochondrial function, folate and methionine metabolism, WNT signaling and cytoskeletal regulation that together implicate relevant signaling and metabolic pathways supporting cell proliferation, morphology and differentiation. We propose that FA supplementation rescues Lrp6(Cd/Cd) fetuses by normalizing hyperactive WNT activity, whereas in LRP6-deficient embryos, added FA further attenuates reduced WNT activity, thereby compromising development.