gebhart/patrepeval huggingface dataset:
Fauna Of Drosophila (Diptera, Drosophilidae) In The Northern Area Of The 'cadeia Do Espinhaco', States Of Minas Gerais And Bahia, Brazil: Biogeographical And Ecological Aspects (1995)

Drosophila fauna from the northem area of the "Cadeia do Espinhao", Brazil is described based on data from 33,985 individuals belonging to 23 species.A total of 28, 796 adults were collected with baits and 5,189 cactophilic individuals were collected at immature stages in cactus species along with the cladode of the host cactus.The occurrence of each species is discussed in biogeographical and ecological terms.It is the first record of the larvae breeding site for both, the endemic South American species and the introduced species.
Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation (1992)

Exposure of human plasma to gas-phase (but not to whole) cigarette smoke (CS) produces oxidative damage to lipids [Frei, Forte, Ames & Cross (1991) Biochem. J. 277, 133-138], which is prevented by ascorbic acid. The ability of CS to induce protein damage was measured by the carbonyl assay and by loss of enzyme activity and protein -SH groups. Both whole and gas-phase CS caused formation of carbonyls in human plasma, which was partially inhibited by GSH but not by ascorbic acid or metal-ion-chelating agents. Isolated albumin exposed to CS showed much faster carbonyl formation (per unit protein) than did whole plasma; damage to isolated albumin was partially prevented by chelating agents. Isolated creatine kinase (CK) lost activity upon exposure to CS much faster than did CK in plasma. Direct addition to plasma of mixtures of some or all of the aldehydes reported to be present in CS caused protein carbonyl formation and inactivation of CK, but neither occurred to the extent produced by CS exposure.
A Community-Based Study of Dementia: The Rotterdam Elderly Study (1992)

The Rotterdam Elderly Study is designed as a community-based prospective follow-up study. The study population consists of almost 12,000 individuals aged 55 years and over who are living in an urban area in Rotterdam, the Netherlands. The objective of the study is to investigate the prevalence, incidence and determinants of neurogeriatric disorders, cardiovascular diseases, locomotor diseases and ophthalmologic diseases. In this paper we give a general outline of the Rotterdam Elderly Study, and a detailed description of the case finding and diagnostic procedures for the study of dementia. The risk factors for dementia that are assessed in the study are summarized.
High-Temperature Phase Change Materials (PCM) Candidates for Thermal Energy Storage (TES) Applications (2011)

It is clearly understood that lower overall costs are a key factor to make renewable energy technologies competitive with traditional energy sources. Energy storage technology is one path to increase the value and reduce the cost of all renewable energy supplies. Concentrating solar power (CSP) technologies have the ability to dispatch electrical output to match peak demand periods by employingthermal energy storage (TES). Energy storage technologies require efficient materials with high energy density. Latent heat TES systems using phase change material (PCM) are useful because of their ability to charge and discharge a large amount of heat from a small mass at constant temperature during a phase transformation like melting-solidification. PCM technology relies on the energyabsorption/liberation of the latent heat during a physical transformation. The main objective of this report is to provide an assessment of molten salts and metallic alloys proposed as candidate PCMs for TES applications, particularly in solar parabolic trough electrical power plants at a temperature range from 300..deg..C to 500..deg.. C. The physical properties most relevant for PCMs servicewere reviewed from the candidate selection list. Some of the PCM candidates were characterized for: chemical stability with some container materials; phase change transformation temperatures; and latent heats.
Dynamic properties of lung parenchyma: mechanical contributions of fiber network and interstitial cells (1997)

We investigated the contributions of the connective tissue fiber network and interstitial cells to parenchymal mechanics in a surfactant-free system. In eight strips of uniform dimension from guinea pig lung, we assessed the storage (G') and loss (G") moduli by using pseudo-random length oscillations containing a specially designed set of seven frequencies from 0.07 to 2.4 Hz at baseline, during methacholine (MCh) challenge, and after death of the interstitial cells. Measurements were made at mean forces of 0.5 and 1 g and strain amplitudes of 5, 10, and 15% and were repeated 12 h later in the same, but nonviable samples. The results were interpreted using a linear viscoelastic model incorporating both tissue damping (G) and stiffness (H). The G' and G" increased linearly with the logarithm of frequency, and both G and H showed negative strain amplitude and positive mean force dependence. After MCh challenge, the G' and G" spectra were elevated uniformly, and G and H increased by < 15%. Tissue stiffness, strain amplitude, and mean force dependence were virtually identical in the viable and nonviable samples. The G and hence energy dissipation were approximately 10% smaller in the nonviable samples due to absence of actin-myosin cross-bridge cycling. We conclude that the connective tissue network may also dominate parenchymal mechanics in the intact lung, which can be influenced by the tone or contraction of interstitial cells.
Fast and efficient MCR-based synthesis of clickable rhodamine tags for protein profiling (2011)

Protein profiling probes are important tools for studying the composition of the proteome and as such have contributed greatly to the understanding of various complex biological processes in higher organisms. For this purpose the application of fluorescently labeled activity or affinity probes is highly desirable. Especially for in vivo detection of low abundant target proteins, otherwise difficult to analyse by standard blotting techniques, fluorescently labeled profiling probes are of high value. Here, a one-pot protocol for the synthesis of activated fluorescent labels (i.e. azide, alkynyl or NHS), based on the Ugi-4-component reaction (Ugi-4CR), is presented. As a result of the peptoidic structure formed, the fluorescent properties of the products are pH insensitive. Moreover, the applicability of these probes, as exemplified by the labeling of model protein BSA, will be discussed.
Phosphoenolpyruvate Carboxylase of Escherichia coli (1972)

Abstract Phosphoenolpyruvate carboxylase was purified from Escherichia coli, strain B (ATCC 11303), and its properties studied. Its amino acid composition and some of its structural properties closely resemble those of the enzyme recently purified by Smith ((1971) J. Biol. Chem. 246, 4234–4241). Steady state kinetics, studied in the presence of the activators acetyl coenzyme A, fructose diphosphate, guanosine triphosphate, and 2-mercaptoethanol, and the inhibitor, l-aspartate, suggest an allosteric enzyme going through ligand-dependent transitions between two discrete states. This conclusion is supported by measurements of optical rotation which show two extreme values attainable in saturating activator, and inhibitor, respectively. The active (R) state is characterized by a single value for Vmax and by a Km of about 0.6 mm for phosphoenolpyruvate, approached at infinite activator concentration. The alternate (T) state, stabilized by aspartate, is catalytically completely inert. The property which distinguishes this enzyme from other phosphoenolpyruvate carboxylases is that upon addition of substrate, steady state velocity develops after a lag period of variable duration. Substrate and activators shorten, but the inhibitor prolongs this lag period. Analysis of the dependence of the lag period on enzyme concentration suggests that at assay dilutions (7 µg per ml) the enzyme is present as an inactive dimer of two peptide chains (mol wt 100,000) which upon addition of substrate, or activators, associates to the active tetramer. The lag period does not completely vanish even at infinite enzyme, substrate, or activator concentrations. The residual lag period is associated with a modification of the enzyme by the substrate, for once the enzyme has reacted with substrate the residual lag period vanishes for several hours, and then gradually returns. A model, compatible with these observations, is suggested.
FM-based indoor localization via automatic fingerprint DB construction and matching (2013)

We present ACMI, an FM-based indoor localization that does not require proactive site profiling. ACMI constructs the fingerprint database based on the pure estimation of indoor RSS distribution, where the signals transmitted from commercial FM radio stations are used. For this, ACMI makes use of our signal model harnessing public transmission information of FM stations in a combination with a floorplan of a building. Using the fingerprint database as the knowledge base, ACMI actively performs multi-level online signal matching to infer the current location of a mobile user. ACMI achieves good indoor localization accuracy even without site profiling efforts. We evaluate ACMI with extensive indoor experiments in 7 different locations with over 1,100 indoor spots. The results show that ACMI achieves up to 89% room identification and accuracy of 6m localization error on average using 8 FM broadcast signals.
Effect of Medroxyprogesterone Acetate on the Digestive and Absorptive Functions of Rat Intestine (1983)

The effects of medroxyprogesterone acetate (MPA) on the digestive and absorptive functions of the small intestinal epithelium have been investigated in female albino rats. The transport of sodium-dependent glucose was significantly enhanced while sodium-independent transport remained unaltered in drug-treated animals. The uptake of amino-acids was also considerably increased, while Ca++ uptake decreased significantly on administration of the drug at a dose of 35 mg/kg body weight once a week for 1 month. Kinetic studies of glucose transport in the presence of sodium ions revealed that MPA treatment affected the rate of uptake of glucose by elevating Vmax, but the Km value remained the same in treated and untreated animals. The administration of the drug also led to significant augmentation in the activities of the brush border enzymes, disaccharidases, and to an insignificant decrease in alkaline phosphatase. The activities of leucine aminopeptidase did not show any change. The enhancement in sucrase activity might be due to induction of the enzyme because only Vmax was elevated in treated animals. As concerns cellular enzymes, lactate dehydrogenase activity was significantly depressed. This study suggests that MPA also exerts glucocorticoid-like effects on the intestinal tissue.
Adaptive Image-Registration-Based Nonuniformity Correction Algorithm With Ghost Artifacts Eliminating for Infrared Focal Plane Arrays (2015)

In this paper, we present a new adaptive image registration nonuniformity correction method with the function of eliminating ghost artifacts. This method assumes that the irradiation of objects stays unchanged during the adjacent two frames' time interval and then corrects the corresponding pixels of two frames by the result of image registration. With regard to real-time continuous image sequence, we first calculate the displacement vectors based on their row and column projections. Then, by bidirectional image registration, we can get the overlapped area matrices of two frames accurately. Meanwhile, a variance threshold is set to judge the scene classification, and then, displacement revising is selectively added to decrease stripe noise. Considering that moving targets exist, the error function for updating is also accordingly adapted to eliminate the ghost artifacts. By using the least-mean-square-error iteration algorithm, the gain and offset coefficients of the overlapped area can be updated in real time with the image sequence adaptively. The advantages of this algorithm lie in its high efficiency of image processing, low computational complexity, and few ghost artifacts. A clean infrared image sequence and two real infrared datasets with nonuniformity are used to compare the ability and correction performance of different algorithms. The results show that our algorithm performs better than other compared algorithms and obtains almost no ghost artifacts.
New Benzoyl Glucosides and Cytotoxic Pterosin Sesquiterpenes from Pteris ensiformis Burm. (2008)

Three new compounds: 2R,3R-pterosin L 3-O-beta-D-glucopyranoside (1), beta-D-xylopyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (2) and 4-O-benzoyl-beta-D-xylo-pyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (3), together with nine known compounds, were isolated from the ethyl acetate extract of Pteris ensiformis. 5-[2-Hydroxyethylidene]-2(5H)-furanone (4), which had been synthesized, was isolated from natural sources for the first time. The structures of all isolated compounds were determined on the basis of mass and spectroscopic evidence. Compound 1 and pterosin B (5) show cytotoxicity against HL 60 cells (human leukemia) with the IC(50) values of 3.7 and 8.7 microg/mL, respectively.
Selective inhibition of virus protein synthesis by prostaglandin A1: a translational block associated with HSP70 synthesis (1994)

Cyclopentenone prostaglandins are potent inhibitors of virus replication. The antiviral activity has been associated with the induction of 70-kDa heat shock protein (HSP70) synthesis. In this report, we describe that in African green monkey kidney cells infected with Sendai virus (SV) and treated with prostaglandin A1 (PGA1), SV protein synthesis was selectively blocked as long as HSP70 was being synthesized by the host cell. The block appeared to be at the translational level, as indicated by the following (i) PGA1 had no effect on SV primary transcription, and a dramatic decrease in the abundance of SV mRNA occurred only at later stages of infection; and (ii) treatment with PGA1 started at 6 h postinfection, at which time SV mRNA had already accumulated in infected cells, did not suppress the levels of NP mRNA, but it reduced the amount of ribosome-bound NP mRNA and caused a dramatic decrease in the level of genomic RNA. The PGA1-induced block of SV protein synthesis appeared to be cell mediated, since it was prevented by actinomycin D, while PGA1 had no effect on SV mRNA translation in vitro. The possibility that HSP70 could be a mediator of the antiviral effect is suggested by the fact that treatment with other classical inducers of HSP70, including sodium arsenite, cadmium, and heat shock at 42 degrees C for 5 h, also selectively prevented SV protein synthesis as long as heat shock protein synthesis occurred. Moreover, SV protein synthesis was not inhibited by PGA1 in murine Friend erythroleukemic cells, which lack the ability to induce HSP70 expression in response to PGA1.
Selective Enzymatic Determination of L-Phenylalanine and Phenyl-Pyruvate (1988)

Abstract A simple enzymatic end point method for the determination of L-phenylalanine and 3-phenylpyruvate has been developed. The assay is based on the spectrophotometry determination of NADH formed or degraded in the reaction catalyzed with Thermoactinomyces intermedins phenylalanine dehydrogenase. This method enables the simple and selective determination of L-phenylalanine and 3-phenylpyruvate based on the high substrate specificity of the enzyme. The assay is sensitive in the range of 0.015−0.15 umol of L-phenylalanine and 3-phenylpyruvate.
La libertad de expresión en el marco de las nuevas tecnologías de la comunicación (2014)

En la vertiginosa expansión de la interconexión tecnológica aplicada a los procesos de la información, la amplitud de tales conexiones y la multiplicación exponencial de los conglomerados, que han devenido, de meros receptores pasivos, en activos emisores, alternando tales papeles; puede hacer parecer que tal posibilidad de feedback ha incrementado y asegurado no sólo la capacidad del ejercicio masivo de una libertad de expresión inédita, sino que ha democratizado, a nivel de una especie de amplia democracia digital, la participación de lo que antes sólo era una masa inerme de receptores. Hemos podido comprobar que tal libertad, si bien se ha extendido su calidad no ha superado realmente las expectativas de una nueva arcadia de la comunicación.
In vitro activity of YM133, a new semisynthesized macrolide (1991)

YM133, the 4"-O-(4-methoxyphenyl)acetyltylosin, is a new macrolide. The in vitro activity of YM133 was compared with those of erythromycin, josamycin, and rokitamycin by an agar dilution method. YM133 inhibited 90% of the tested isolates of Streptococcus pneumoniae, Legionella spp., and anaerobic bacteria at less than or equal to 1.56 micrograms/ml. The drug inhibited 90% of erythromycin-resistant staphylococci and Streptococcus pyogenes at less than or equal to 50 micrograms/ml. YM133 showed activity against erythromycin-, josamycin-, and rokitamycin-resistant (MIC greater than or equal to 100 micrograms/ml) strains of staphylococci, streptococci, Bacteroides spp., and Clostridium spp. Enterococci were less susceptible to other YM133-like macrolides. Unlike other macrolides, YM133 showed killing activity, and the MBC/MIC ratios of YM133 for several strains were 1:32, whereas those of erythromycin were 4:1,024. In a time-kill curve study, the reduction of viable cells started within 2 h after the addition of YM133.
Bidirectional solid-phase peptide synthesis. Extension of the dinitrophenylene-bridging method to cysteine-containing peptides (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBidirectional solid-phase peptide synthesis. Extension of the dinitrophenylene-bridging method to cysteine-containing peptidesJohn D. Glass, A. Talansky, Z. Grzonka, I. L. Schwartz, and Roderich WalterCite this: J. Am. Chem. Soc. 1974, 96, 20, 6476–6480Publication Date (Print):October 1, 1974Publication History Published online1 May 2002Published inissue 1 October 1974https://pubs.acs.org/doi/10.1021/ja00827a035https://doi.org/10.1021/ja00827a035research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enhancing the Security and Privacy of Self-Sovereign Identities on Hyperledger Indy Blockchain (2020)

Self-sovereign identities provide user autonomy and immutability to individual identities and full control to their identity owners. The immutability and control are possible by implementing identities in a decentralized manner on blockchains that are specially designed for identity operations such as Hyperledger Indy. As with any type of identity, self-sovereign identities too deal with Personally Identifiable Information (PII) of the identity holders and comes with the usual risks of privacy and security. This study examined certain scenarios of personal data disclosure via credential exchanges between such identities and risks of man-in-the-middle attacks in the blockchain based identity system Hyperledger Indy. On the basis of the findings, the paper proposes the following enhancements: 1) A novel attribute sensitivity score model for self-sovereign identity agents to ascertain the sensitivity of attributes shared in credential exchanges 2) A method of mitigating man-in-the-middle attacks between peer self-sovereign identities and 3) A novel quantitative model for determining a credential issuer's reputation based on the number of issued credentials in a window period, which is then utilized to calculate an overall confidence level score for the issuer.
High-speed current mirror resistive compensationtechnique (1995)

In the Letter the authors propose a very simple but powerful method of speed and bandwidth enhancement for general CMOS current mirror circuits. Introducing a compensation resistor between the gates of the primary transistor pair of the current mirror can lead to a significant bandwidth enhancement. Simulated and measured results are presented.
A scheduling algorithm for pipelined data path synthesis with gradual mobility reduction (2003)

We propose a scheduling algorithm for the pipelined data path with resource constraint. The algorithm first checks the possibility of scheduling in the case of being assigned to the earliest step or to the latest step among the assignable control steps of all operations. If it is impossible to assign an operation to those steps due to resource constraint violation, the algorithm does away with those steps, that is, reduces the mobility of the operation. The scheduling algorithm is iterated until final schedule is obtained. If the final schedule is not obtained, even though there is no operation to reduce a mobility, we select a proper operation to reduce the mobility using the current scheduling state that is represented by parameters. A 16 point FIR filter and 5th order elliptic wavefilter are used to illustrate the scheduling algorithm.
Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in chinese patients (2006)

Ulcerative colitis (UC) is characterized by chronic intestinal inflammation as a result of an exaggerated T cell response. Cytotoxic T lymphocyte associated antigen-4 (CTLA-4), expressed mainly in activated T cells, inhibits T cell activation and proliferation by combining B7 through competing CD28 and maintains immune homeostasis. Polymorphisms of the CTLA-4 gene are known to be associated with several autoimmune diseases. The aim of this study was to investigate the association between the CTLA-4 gene microsatellite polymorphism and UC in Chinese patients. Unrelated 100 Chinese patients with UC and 140 healthy controls were studied. The (AT) repeats in the 3' untranslated region of exon 4 of the CTLA-4 gene were amplified by allele-specific polymerase chain reaction (PCR). The amplified products were electrophoresed on a 12% polyacrylamide gel, followed by silver staining. Twenty alleles were found in Chinese patients and healthy controls. The 122-bp allele was increased in UC compared with healthy controls (9.5% vs 0.7%, P = 0.0001/Pc = 0.002, OR = 14.591, 95%CI 3.357-63.420). The frequency of the longer alleles (>or=118 bp) of UC was higher than that in healthy controls (26% vs 4%, P = 0.0001/Pc = 0.0002, OR = 7.644, 95%CI 3.950-14.792), but was not associated with location and severity of the disease. Furthermore, the longer alleles were not associated with haplotypes of C-318T/A+49G of the CTLA-4 gene in Chinese patients with UC. The longer alleles of the CTLA-4 gene microsatellite polymorphism were strongly associated with UC in Chinese patients.