gebhart/patrepeval huggingface dataset:
Characteristics of Link-Type Cubic Anvil, High Pressure-High Temperature Apparatus (1971)

Operational characteristics are investigated for evaluation and improvement of a high pressure apparatus which has a new anvil-driving mechanism. Analysis and measurement of anvil motion reveales that a very accurate anvil-alignment is achieved and maintained throughout hundreds of usages. Pressures are generated up to 100 kbar with avils having square faces 10 mm on an edge, and 120 kbar with anvils having square faces 6.4 mm on an edge. A method is devised to correct the effect of elastic deformation in structural parts, and completely isotropic compression is realized. Temperatures higher than 2000°C are attained in samples, 4 mm in diameter and 8 mm in length, while anvil-temperatures do not exceed 300°C. Operational ease and long anvil-life in the apparatus are attributed to the new anvil driving mechanism.
Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol (2003)

A proportion of neural tube defects (NTDs) can be prevented by maternal folic acid supplementation, although some cases are unresponsive. The curly tail mutant mouse provides a model of folate-resistant NTDs, in which defects can be prevented by inositol therapy in early pregnancy. Hence, inositol represents a possible novel adjunct therapy to prevent human NTDs. The present study investigated the molecular mechanism by which inositol prevents mouse NTDs. Activation of protein kinase C (PKC) is known to be essential, and we examined neurulation-stage embryos for PKC expression and applied PKC inhibitors to curly tail embryos developing in culture. Although all known PKC isoforms were detected in the closing neural tube, use of chemical PKC inhibitors identified a particular requirement for 'conventional' PKC isoforms. Peptide inhibitors offer selective inhibition of individual PKCs, and we demonstrated isoform-specific inhibition of PKC in embryonic cell cultures. Application of peptide inhibitors to neurulation-stage embryos revealed an absolute dependence on the activity of PKCbetaI and gamma for prevention of NTDs by inositol, and partial dependence on PKCzeta, whereas other PKCs (alpha, betaII delta, and epsilon) were dispensable. To investigate the cellular action of inositol and PKCs in NTD prevention, we examined cell proliferation in curly tail embryos. Defective proliferation of hindgut cells is a key component of the pathogenic sequence leading to NTDs in curly tail. Hindgut cell proliferation was stimulated specifically by inositol, an effect that required activation of PKCbetaI. Our findings reveal an essential role of specific PKC isoforms in mediating the prevention of mouse NTDs by inositol.
Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: concentration thresholds and implications for clinical efficacy (2009)

The concentration threshold of 500 microM to 2 mM exhibited for antitumor activity by GLA and ALA is much higher than that observed in most previously reported cell culture studies but consistent with physiological concentrations found to kill tumor clinically and in animals. A mechanism of antitumor activity by unsaturated fatty acids through selective destabilization of the malignant plasma membrane is considered. An oral regimen is proposed for phase I clinical testing that could push the area under the curve for serum concentration of unbound unsaturated fatty acids over time to much higher levels than previously achieved for systemic administration and into the range that could yield antitumor response.
Overview of Drug Product Development (2001)

Drug product development, also called formulation chemistry, is the process of developing formulations for use in toxicology and clinical studies and for commercial supply. In this overview, the development process is described, including dosage forms for various delivery routes, toxicology formulation development, ingredient selection and manufacturing process development.
Phase function simulation in tissue phantoms: a fractal approach (1996)

Artificial media are needed for the calibration of optical diagnostic methods in order to work on reproducible, stable and well known samples. Since the scattering and absorption coefficients can easily be adjusted by using appropriate concentrations of scattering and absorbing components, the most difficult part in the design of a good tissue phantom is to obtain an actual phase function. The most common way to create phantoms is to use scattering microspheres of equal size, but the Mie phase function of such a phantom does not match the tissue's real phase function. Moreover, we show in this paper that the similarity relations often used for the analysis of the results obtained with this type of phantom may sometimes be very inaccurate. The use of a mixture of different sized scattering particles is then considered, in order to imitate the whole phase function. However, as the determination of adequate sizes and concentrations is a difficult mathematical task, we describe a simple method to solve this problem. We first demonstrate that the extreme optical complexity of real biological samples could be simulated by a mixture of spheres with a fractal diameter distribution. Then, we present a few simple rules based on the knowledge of this fractal distribution, which can be used to obtain a realistic phase function with a limited number of sphere diameters.
CONGENITAL CYTOMEGALOVIRUS INFECTION IN A HIGHLY SEROPOSITIVE SEMI-URBAN POPULATION IN INDIA (2008)

To determine the incidence and natural history of congenital cytomegalovirus (CMV) infection in a population of women with near universal serologic reactivity for CMV, a prospective study of 423 women attending the antenatal clinic of the Comprehensive Rural Health Center in northern India was conducted. All 9 (2.1%) CMV positive infants were born to mothers who were CMV seropositive at the first antenatal visit. One child had hepatosplenomegaly at birth and another child had mild unilateral hearing loss at 4 months of age.
Optical heterodyne communications experiments at 10.6 µ (1968)

A 10.6-μ optical heterodyne communication system that is in operation over a 30-km (18-mile) path is described. Television signals have been transmitted over the beam by the use of optical FM achieved with internal electrooptic phase modulation of the transmitter oscillator. A frequency deviation of 3 MHz is thus obtained for a driving voltage of 1 kV compared with the fundamental frequency noise of the system of about 1 kHz. For clear-day operation, average carrier-to-noise ratios at the receiver approach 60 dB, and demodulated video signal-to-noise ratios average 50 dB. Optical propagation experiments reveal amplitude scintillation noise in excess of 20 dB, represented by fluctuations of +10 dB and -10 dB from the average carrier level. Other observations show that the 10.6-μ beam has a remarkable ability to penetrate fog. Data related to scintillation, visibility, temperature, humidity, and optical absorption are presented.
Influence of cardiac neural inputs on rhythmic variations of heart period in the cat (1975)

Spectral analysis was used to investigate variations of heart period in 13 decerebrate cats under different conditions of neural input to the heart. Spectral density plots in intact animals showed three well-defined peaks: P1 (1.5-2.5 cycles/min), P2 (6-10 cycles/min), and P2 (respiratory frequency). In the presence of sympathetic input only the amplitudes of all peaks were decreased; when only vagal input was present the amplitudes of P1 and P2 were increased and there was no change in P3; when neither sympathetic nor vagal input was present the amplitudes of all peaks were decreased. In addition, the amplitudes of P1 and P2 were increased and there was no change in P3; when neither sympathetic nor vagal input was present the amplitudes of all peaks were decreased. In addition, the amplitudes of P1 and P2 were found to be significantly correlated with the mean heart period under the condition of vagal control only. It is concluded that P3 is related to sinus arrhythmia and that P1 and P2 may be related to spontaneous rhythms that are an intrinsic feature of the dynamic regulation of heart period by the vagus system. Sympathetic activity plays no role in the genesis of these rhythms.
Preparation of Animals with a High Degree of Chimerism by One-Step Coculture of Embryonic Stem Cells and Preimplantation Embryos (1997)

A single-step coculture procedure has been developed that can generate chimeric mice with high efficiency and reproducibility. The procedure involves culture of embryonic stem (ES) cells with 8- to 16-cell embryos in microwells to provide conditions for effective cell-cell-embryo contact. A suspension of ES cells is layered over the microwells, followed by transfer of an embryo without zona pellucida into each microwell. Following overnight culture, the blastocysts are transferred into pseudopregnant recipients. The method has several advantages due to its simplicity and reproducibility: (i) Over 90% of ES-cell contribution in new-borns can be obtained frequently and most of the chimeras display germ-line transmission. (ii) The procedure does not require specialized skills or expensive instruments. (iii) All the steps of embryo manipulation can be completed in a relatively short period of time; therefore, a large number of embryos can be manipulated simultaneously. The method was tested with three independent ES cell lines and two different strains of mice with similar results. The technique may be an alternative to microinjection of DNA into zygotes to prepare transgenic lines of small and large mammalian species.
Off-axis catadioptric fisheye wide field-of-view optical receiver for free space optical communications (2012)

We propose a wide field-of-view optical receiver design based on a fisheye lens and an off-axis catadioptric structure for free-space optical communications. The design utilizes a novel fisheye lens group to compress a wide field angle into a narrow field angle and produce the appropriately collimated light that can effectively be coupled into the following aperture of a catadioptric telescope. An off-axis catadioptric telescope with aspheric surface mirrors is designed to compress the incident beam spot size, compensate for the high order optical aberrations and eliminate light loss due to an obstruction. The parallel exit rays are reflected on a double-level tracking mechanism by feeding the position signal from a quadrant detector to correct the pointing error and optimize the coupling efficiency into an optical fiber. The final wide field-of-view optical receiver design is presented along with the evaluation of optical performance results and tracking characteristics. The proposed optical receiver not only can provide a 60-deg wide field-of-view to expand the tracking range, but also mitigates optical aberrations to improve the tracking accuracy for free space optical communication systems in a turbulent atmosphere.
Introducing EPOS in Bass Taverns: a report of the case and an exploration of some of the issues (1998)

IT projects frequently fail, and many of those which survive do not deliver all they promise. In this paper, the authors discuss factors affecting the success and failure of IT projects and raise a number of questions. They report on a successful IT project at Bass Taverns, and see how this case study sheds light on the questions raised.
In Vitro Antimalarial Activity of Nucleic Acid Precursor Analogues in the Simian Malaria <i>Plasmodium knowlesi</i> (1974)

Analogues of nucleic acid precursors were screened for antimalarial activity in Plasmodium knowlesi by using an in vitro culture system. Activity was assessed by the degree of inhibition of incorporation of l-[methyl-(14)C]methionine into protein and of [8-(14)C]adenosine and [6-(14)C]orotic acid into ribonucleic acid and deoxyribonucleic acid. The incorporation of adenosine or orotic acid was effectively inhibited by many of the compounds, including 3' analogues of purine nucleosides, many of the 6-position analogues of purine bases and nucleosides, and 5-position analogues of orotic acid. Only a few compounds inhibited methionine incorporation into protein, and in each instance adenosine or orotic acid incorporation also was inhibited. Some compounds inhibited adenosine or orotic acid incorporation into both ribonucleic acid and deoxyribonucleic, whereas other analogues inhibited incorporation into one nucleic acid only. The qualitative and quantitative differences suggest that this experimental system may be appropriate for investigation of metabolic pathways of the malaria parasite, as well as for demonstration of antimalarial activity of candidate antimalaria drugs.
A Novel Class of Inhibitors for Human and Rat Steroid 5.ALPHA.-Reductases: Synthesis and Biological Evaluation of Indoline and Aniline Derivatives. III. (2000)

While searching for novel nonsteroidal inhibitors of human and rat prostatic 5alpha-reductases, we found a new series of indoline and aniline derivatives that showed potent inhibitory activities for both enzymes. Among them, 3-chloro-4-¿[1-(4-phenoxybenzyl)indolin-5-yl]oxylbenzoic acid (2e, YM-36117) showed a more potent inhibitory activity for the human enzyme than ONO-3805 with an IC50 value of 5.3 nM and a reduced rat prostatic dihydrotestosterone (DHT) concentration by oral administration. The synthesis and the structure-activity relationships of these indoline and aniline derivatives are presented.
Cortical pain responses in the infant brain (2006)

University College London, Anatomy and Developmental Biology, Gower Street, London WC1E 6BT, UK *Corresponding author. Tel.: +44 7789793378. E-mail address:[email protected]
Detection and Staging of Dementia in Alzheimer's Disease (1992)

Our earlier studies using the Consortium to Establish a Registry of Alzheimer's Disease neuropsychological battery showed that delayed recall was a highly sensitive indicator of early Alzheimer's disease. None of the learning and memory measures in the battery were found to be useful in staging the severity of this form of dementia. This study explores the nonmemory functions (fluency, naming, and praxis) of the Consortium to Establish a Registry of Alzheimer's Disease battery and asks whether performance on any of these measures adds to the detection of early Alzheimer's disease or is sensitive to the later progression of the illness. We stratified patients with this disease according to severity (mild, moderate, severe), and compared them with age-, education-, and gender-matched control subjects (group N = 49 each). Multivariate procedures and cutting scores were used to determine the efficacy of the various measures in distinguishing between the cases and control subjects. Impairment of delayed recall was again found to be the best discriminator for detecting mild cases of Alzheimer's disease. Confrontation naming was the only nonmemory factor that assisted in this discrimination. For staging the illness, a combination of measures including fluency, praxis, and recognition memory best differentiated cases with mild dementia from those with either moderate or severe stages of disease. Measures of delayed recall quickly "bottomed out" in the patients with Alzheimer's disease and proved of little value in staging the disorder.(ABSTRACT TRUNCATED AT 250 WORDS)
Phase-locked (GaAl)As laser diode emitting 2.6 W CW from a single mirror (1983)

A phase-locked multiple-quantum-well (GaAl)As injection laser with a highly reflective rear facet coating and a low reflective front facet coating is reported to emit 2.6 W CW at room temperature from the front facet.
Comparative Analysis of Endophytic Bacterial Communities in the Roots of Rice Grown under Long-term Fertilization Practice using Pyrosequencing Method (2012)

화학비료의 장기 시용이 벼 내생 세균 군집에 미치는 영향을 조사하기 위해서 국립농업과학원의 장기 비료 연용 포장에서 재배한 벼 뿌리의 내생균의 군집을 파이로시퀀싱 기법으로 분석하였다. 3요소구 (APK)와 무비구 (NF) 시료에서 직접 DNA를 추출하여 세균에 특이적인 barcode PCR을 수행한 후 454 파이로시퀀싱을 하였다. 두 시료 (3요소구, 무비구)에서 1,900개의 염기서열을 얻었으며, 각각 177개와 72개의 OTU로 분류하였다. 두 시료는 22개의 OTU를 공유하였으며, 이들 OTU는 두 시료에서 모두 우점하였다. 특히 Pseudomonas속에 속하는 OTU의 비율이 매우 높았다. 문 (phylum) 수준에서 우점하는 내생균은 두 시료 모두 Gammaproteobacteria, Alphaproteobacteria, Betaproteobacteria, Actinobacteria 등 이었다. 처리구별로 계산한 다양성 지수는 3요소구 시료에서 더 높았다. 본 연구를 통해 장기간 비료 시용은 식물체내 존재하는 내생균 군집 구조에 영향을 주며, 벼 뿌리의 내생 세균의 군집 다양성을 증가시키는 것을 알 수 있었다. Bacterial endophytes may be important factors in plant growth and ecologically relevant functions in rice. Using pyrosequencing technology, we analyzed the composition of endophytic bacterial communities that colonized the roots of rice cultivated in long-term fertilized (APK) and non-fertilized (NF) paddy soils. A total of 1,900 reads were obtained from 2 samples. All sequences were classified into 177 OTUs (APK sample) or 72 OTUs (NF sample) at a 97% similarity cut-off. Twenty-two OTUs were shared between the 2 samples, and these were also the most dominant OTUs in both samples. Proteobacteria was the most dominant phylum with 90.2%, followed by Actinobacteria (7.1%) and Bacteroidetes (1.1%). Furthermore, Pseudomonas was the most abundant genus in both samples. We observed clear differences in the structure of the endophytic bacterial community structure between the 2 samples. Notably, the distributions of Alphaproteobacteria and Gammaproteobacteria were markedly different. The diversity index of the APK sample was higher than that of the NF sample. These findings showed that the endophytic bacterial community of rice roots was affected by the presence of fertilizers in the rice field soil.
Halogenation Using Quaternary Ammonium Polyhalides. XXXI Halogenation of Thiophene Derivatives with Benzyltrimethylammonium Polyhalides (1991)

Abstract The reactions of thiophene derivatives with benzyltrimethylammonium tetrachloroiodate, benzyltrimethylammonium tribromide, and benzyltrimethylammonium dichloroiodate in acetic acid or in acetic acid–zinc chloride under mild conditions gave chloro-, bromo-, and iodo-substituted thiophene derivatives, respectively, in satisfactory yields.
Lattice strain and lattice dynamics of ZnSe-ZnTe strained-layer superlattices (1987)

Lattice strain and lattice dynamics of ZnSe-ZnTe strained-layer superlattices (SLSs) were examined by means of transmission electron microscopy and Raman scattering. Superlattice structures were confirmed from both transmission electron diffraction patterns and bright field images of the samples. Lattice distortions which originated from misfit strains were observed by the lattice image mode. The crystallinity of the adjacent layers was degraded when the layer thickness became large and polycrystalline structures were observed when the layer thickness exceeded the critical layer thickness. Raman scattering was used to assess the magnitude of the strain in the SLSs. Optical phonon frequencies of the components in SLSs were different from those frequencies of the bulk materials. The frequency shifts were used to quantify the strains in the SLSs. The observed shifts corresponded to the calculated values.
Does “Hidden Undercuffing” Occur Among Obese Patients? Effect of Arm Sizes and Other Predictors of the Difference Between Wrist and Upper Arm Blood Pressures (2009)

Arm size can affect the accuracy of blood pressure (BP) measurement, and "undercuffing" of large upper arms is likely to be a growing problem. Therefore, the authors investigated the relationship between upper arm and wrist readings. Upper arm and wrist circumferences and BP were measured in 261 consecutive patients. Upper arm auscultation and wrist BP was measured in triplicate, rotating measurements every 30 seconds between sites. Upper arm BP was 131.9+/-20.6/71.6+/-12.6 mm Hg in an obese population (body mass index, 30.6+/-6.6 kg/m(2)) with mean upper arm size of 30.7+/-5.1 cm. Wrist BP was higher (2.6+/-9.2 mm Hg and 4.9+/-6.6 mm Hg, respectively, P<.001); however, there was moderate concordance for the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) strata (kappa value=0.27-0.71), and the difference was >or=5 mm Hg in 72% of the patients. The authors conclude that there was poor concordance between arm and wrist BP measurement and found no evidence that "hidden undercuffing" was associated with obesity; therefore, they do not support routine use of wrist BP measurements.
Image block partitioning: a compression technique suitable for parallel processing (1992)

Presents a simple scheme of fixed size image block partitioning that offers a solution to the two limitations, for little overhead in complexity and compression efficiency. The scheme can be extremely useful in systems where parallel processing is a necessary requirement for the achievement of the required processing throughput and in future systems that compressed images will reside in memory or storage media, and only part of them will be requested at a time, such as a display window system, or multi-media applications.
Structure Analysis of Intercalated Zirconium Phosphate Using Molecular Simulation (1998)

Molecular simulation supported by X-ray diffraction and IR spectroscopy has been used to analyse the structure of α-zirconium phosphate intercalated by ethanol, Zr(HPO 4 ) 2 .2C 2 H 5 OH. Molecular-mechanics simulations using the Crystal Packer module in the Cerius 2 modelling environment revealed the crystal packing in the interlayer, i.e. the positions of ethanol with respect to the Zr(HPO 4 ) 2 layers and the layer stacking in the intercalated structure. The average interlayer distance d \,=\,14.03 (13) Å obtained by modelling is in agreement with the experimental d value of 14.05 (4) Å obtained from the X-ray diffraction analysis. The disorder in the Zr(HPO 4 ) 2 .2C 2 H 5 OH structure found by molecular simulation has been confirmed by the character of the X-ray diffraction pattern.