Aerosol Pentamidine (1988)

Editorials1 December 1988Aerosol PentamidineDonald Armstrong, MD, Edward Bernard, BADonald Armstrong, MD, Edward Bernard, BAAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-11-852 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAerosol pentamidine is widely used for prophylaxis and treatment of Pneumocystis carinii pneumonia, even though the Food and Drug Administration has not approved it for any indication. The widespread use arose because injectable pentamidine is approved for treating P. carinii pneumonia, and it became common practice to administer solutions using a nebulizer. Aerosol pentamidine is now the most frequently used experimental drug for disease related to the acquired immunodeficiency syndrome (AIDS).The first reports of efficacy in prophylaxis in rats appeared in 1985, and prophylactic use has grown, in spite of the paucity of well designed and supervised clinical trials....References1. Gajdusek D. Pneumocystis carinii as the cause of human disease: historical perspective and magnitude of the problem. Introductory remarks. National Cancer Institute Monograph 43, October 1976. Google Scholar2. GottliebSchroffSchanker MRH. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. N Engl J Med. 1981;305:1425-31. CrossrefMedlineGoogle Scholar3. MasurMichelisGreene HMJ. An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N Engl J Med. 1981;305:1431-8. CrossrefMedlineGoogle Scholar4. SiegalLopezHammer FCG. 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Picea, MDAerosolized PentamidineEran Bellin, MD 1 December 1988Volume 109, Issue 11Page: 852-854KeywordsAIDSClinical trial reportingDrugsFood and Drug AdministrationPneumocystis carinii pneumoniaPneumoniaProphylaxis Issue Published: 1 December 1988 PDF DownloadLoading ...