gebhart/patrepeval huggingface dataset:
Actions of TNF‐α on glutamatergic synaptic transmission in the central nervous system (2005)

Increasing attention is being paid to the role of inflammatory and immune molecules in the modulation of central nervous system (CNS) function. Tumour necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine, the receptors for which are expressed on neurones and glial cells throughout the CNS. Through the action of its two receptors, it has a broad range of actions on neurones which may be either neuroprotective or neurotoxic. It plays a facilitatory role in glutamate excitotoxicity, both directly and indirectly by inhibiting glial glutamate transporters on astrocytes. Additionally, TNF-alpha has direct effects on glutamate transmission, for example increasing expression of AMPA receptors on synapses. TNF-alpha also plays a role in synaptic plasticity, inhibiting long-term potentiation (LTP), a process dependent on p38 mitogen activated kinase (p38 MAP) kinase. In the following review we look at these and other effects of TNF-alpha in the CNS.
빅데이터 환경에서 기업 마케팅 활용 방안 (2013)

최근에 인터넷의 발전으로 인하여 기업의 마케팅도 변화하고 있다. 소설네트워크서비스(SNS)가 등장하고 이를 이용하는 사용자가 많아짐에 따라 기업에서는 사용자를 위한 새로운 마케팅으로 빅데이터를 활용하는 방법을 생각하고 있다. 하지만 기업에서는 SNS 이용하는 사용자의 생각과 관심을 찾기가 쉽지 않아 SNS 마케팅을 활용하기 힘들고 정보도 많이 부족하다. 따라서 빅데이터의 사용자가 선호하는 것, 좋아하는 것, 싫어하는 것과 같은 생각을 분석하기 위한 방법이 필요하다. 이처럼, 본 논문에서는 이러한 문제점을 해결하고자 빅데이터를 분석함으로써 기업에게 정확성하고 신뢰성 있는 정보를 제공하여 정보의 가치를 높여 기업의 마케팅에서 활용할 수 있는 방안에 대해 연구한다.
Invasive tumor cells and prognosis in a selected population of patients with glioblastoma multiforme (2008)

Aggressive tumor removal may improve survival, but the current results indicated that biologic commitment of 'penumbra' cells appear to be the most relevant factor for tumor recurrence and accounts for the fatal outcome of the disease.
Relative Biological Effectiveness of Accumulated<sup>125</sup>IdU and<sup>125</sup>I-Estrogen Decays in Estrogen Receptor-Expressing MCF-7 Human Breast Cancer Cells (2001)

The therapeutic potential for delivering a cytotoxic dose of radiation (using the decay of Auger-electron emitters) to the cell nucleus of cancer cells that express estrogen receptors (ERs) by radiolabeled estrogen was investigated in the ER-expressing human breast cancer cell line, MCF-7. The radiolabeled estrogen/ER complex irradiates the cell nucleus by binding specific DNA sequences called estrogen response elements (EREs). Cell clonogenicity and induction of DNA double-strand breaks (DSBs) by gamma radiation or accumulation of (125)I-iododeoxyuridine ((125)IdU) or E-17alpha[(125)I]iodovinyl-11betamethoxyestradiol ((125)IVME2) decays were determined. MCF-7 cells were efficiently killed by accumulation of (125)IdU (D(0) = 30 decays per cell) and (125)IVME2 decays (D(0) = 28 decays per cell). DNA DSBs were induced by the accumulation of (125)IdU (approximately 3750 decays per cell required to reduce the mean value of the elution profile to 50%) or (125)IVME2 decays (approximately 465 decays per cell required to reduce the mean value to 50%). For survival of MCF-7 cells after gamma irradiation, the D(0) was 1 Gy, and approximately 65 Gy was required to reduce the mean value to 50% for induction of DSBs. The RBE values for cell killing and induction of DSBs by (125)IVME2 relative to gamma radiation were 4.8 and 18.8, respectively. The RBE values for cell killing and induction of DSBs by (125)IdU relative to gamma radiation were 4.5 and 2.3, respectively. Cell killing in a manner similar to that induced by high-LET radiation and the high RBE for induction of DSBs by (125)IVME2 in the ER-expressing MCF-7 cells provide a biological rationale for the use of Auger electron-emitting radionuclides covalently bound to estrogen to deliver a cytotoxic dose of radiation to ER-positive cancers.
Thermophysical properties of the Earth's crust: In situ measurements from continental and ocean drilling (1990)

Knowledge of the variation of thermal conductivity and heat production with depth is critical to understanding the thermal state of the crust. Continental and oceanic drill holes provide unique opportunities for the calibration of empirical and theoretical models relating crustal thermal properties to physical and chemical properties. These calibrations are based on more than 30,000 well log measurements of acoustic velocity (both compressional and shear), density, porosity, radioelement concentrations (K, U, Th), and major element chemistry (Al, Si, Ca, Fe, S, Mg + Na), in formations ranging in age from 5 to 620 Ma and in composition from granitic to gabbroic. The mineralogical data available from induced gamma ray spectroscopy logs, when combined with known mineral thermal conductivities in a model for the thermal conductivity of a crystalline aggregate, enable the in situ application of a laboratory estimation technique and yield continuous conductivity profiles. However, mineralogy‐based conductivity models cannot account for the anisotropic conductivity observed in foliated metamorphic rocks. A phonon conduction model, which utilizes acoustic velocity and bulk density measurements, is accurate within ±15% in both isotropic and anisotropic formations of the upper continental crust and in oceanic crustal layers 2C and 3. In oceanic crustal layers 2A and 2B, however, the effects of fracturing on compressional and shear velocities lead to inaccurate results. The heat flow‐heat production relationship, which provides one method of determining subsurface heat production, has well‐documented limitations. Allis (1979) and Rybach and Buntebarth (1982, 1984), on the basis of laboratory measurements, have proposed quantitative relationships between heat production and rock compositional and physical properties. The well log K, U, and Th data indicate that heat production can be predicted from compositional data within a factor of 2 or 3. Predictions of heat production from acoustic velocity and bulk density measurements are only accurate to within an order of magnitude. Three factors account for these results: (1) the natural variability of velocity and density for a given rock composition, (2) the tendency of U and Th to associate with secondary rather than primary minerals, and (3) U and Th redistribution through fluid flow and metamorphism. Thus seismic velocity based heat production profiles can, at best, be taken as first‐order estimates which may misrepresent the complexity of the continental crust. However, the correlation of formations of known heat production with subsurface structures, when combined with a suite of existing techniques for estimating heat production, may lead to more accurate results.
Dengue viruses – an overview (2013)

Dengue viruses (DENVs) cause the most common arthropod-borne viral disease in man with 50-100 million infections per year. Because of the lack of a vaccine and antiviral drugs, the sole measure of control is limiting the Aedes mosquito vectors. DENV infection can be asymptomatic or a self-limited, acute febrile disease ranging in severity. The classical form of dengue fever (DF) is characterized by high fever, headache, stomach ache, rash, myalgia, and arthralgia. Severe dengue, dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) are accompanied by thrombocytopenia, vascular leakage, and hypotension. DSS, which can be fatal, is characterized by systemic shock. Despite intensive research, the underlying mechanisms causing severe dengue is still not well understood partly due to the lack of appropriate animal models of infection and disease. However, even though it is clear that both viral and host factors play important roles in the course of infection, a fundamental knowledge gap still remains to be filled regarding host cell tropism, crucial host immune response mechanisms, and viral markers for virulence.
Joint Adaptive Compensation for Amplifier Nonlinearity and Quadrature Modulation Errors (2006)

This paper proposes a technique that jointly compensates the amplifier nonlinearity and quadrature modulation (QM) errors. The proposed method is derived based on the indirect learning architecture, which has been originally developed for the predistortion (PD). The proposed compensator updates the parameter vector based on the recursive least squares (RLS) criterion. The advantage of the proposed adaptive technique is demonstrated through computer simulation.
Analysis of dynamic behaviors of tandem cold mills using generalized dynamic and control equations (2000)

A generalized equation set is proposed to investigate dynamic behaviors of tandem cold mills. The system is composed of the intrastands and the interstands equations and the boundary conditions of the first and the last mill stands. The solution provides detailed dynamic effects of disturbance variables such as anneal and entry gauges, hardness, and roll eccentricity. The transportation delay is considered as well. The mill dynamic equations and the control equations can be combined to form a linear system. The mill performance and the actuator response can be solved directly from the linear system.
Drug Release Kinetics From Stent Device-Based Delivery Systems (2008)

In an effort to overcome the limitations of balloon-expandible intravascular metal stent-induced neointimal formation, drug-coated stent devices have been developed. The stent platform allows the local delivery of drugs to an injury site, thereby reducing the amount of drug exposure to the systemic circulation and other organs. The drug carrier matrix allows the release of the drug in a diffusion-controlled manner over an extended time period after the stent implant. The drugs are chosen such that the complex cascade of events that occurs after stent implantation that leads to smooth muscle cell proliferation and migration towards the intima are inhibited. The success of an antirestenotic drug therapy from a drug-coated stent is dependent, at least partially, on the extent of drug elution from the stent, the duration and rate of release, and accumulation of drug in the arterial wall in such a way that it covers the initiation and progression of vessel wall remodeling. The local vascular drug concentrations achieved are directly correlated with the biological effects and local vascular toxicity, and there is therefore a challenge in finding an optimum dose of drug to be delivered to tissues (ie, one that has the desired therapeutic effect without local adverse effects). There is increased focus on optimization of various factors that affect drug release from the stent system, including the physicochemical properties of the drugs, carrier vehicle formulation, and profile of elution kinetics. This review highlights the various factors involved in drug release kinetics, local vascular toxicity, carrier vehicle matrix, tissue deposition, and distribution through the arterial wall from stent-based drug delivery systems.
Liposomes as Vehicles for the Local Release of Drugs (1975)

1. The rat testicle was used in studying the release of radio-labelled compounds from locally injected liposomes of various sizes, charge and lipid composition. 2. Large unsonicated liposomes markedly delayed the release of entrapped 125I-labelled albumin. Delay was due to liposomal entrapment rather than the presence of lipid per se and it was greater with neutral than charged liposomes. The albumin left the testis after release from, and not in association with, liposomal lipid. 3. Large unsonicated liposomes also delayed the release of entrapped actinomycin D and 5-fluourouracil. The former retained its cytotoxic activity and resulted in focal, dose-dependent tissue necrosis. 4. Small sonicated liposomes did not delay the release of entrapped 125I-labelled albumin, and enhanced release of actinomycin D, producing high concentration of these compounds, which were released in association with liposomal lipid, in draining lymph nodes.
Intention to use new mobile payment systems: a comparative analysis of SMS and NFC payments (2017)

The rapid growth of mobile technology among the world’s population has led many companies to attempt to exploit mobile devices as an additional tool in the business of sales. In this sense, the main objective of our study resides in comparing the factors that determine the acceptance by consumers of the SMS (Short Message Service) and NFC (Near Field Communication) mobile payment systems as examples of means of future payment. The model used in our research applies the classic variables of the Technology Acceptance Model, as well as that of Perceived Security, a model deriving from the review of the major relevant recent literature. The results achieved in this study demonstrate that there are differences in the factors that determine the acceptance in each of the systems, as well as the level of the Intention to Use. Finally, we highlight the main implications for management and cite some strategies to reinforce this new business in the context of new technical developments.
Estimation of Rotor Loads Due to Wake Steering (2018)

Abstract not provided.
Microcirculatory Responses to Acupuncture Stimulation and Phototherapy (2009)

Acupuncture stimulation and phototherapy were directly confirmed to increase the diameter and blood flow velocity of the peripheral arterioles. Acupuncture stimulation and phototherapy, associated with minimal systemic and local side effects, can enhance the microcirculation and may be a useful supportive treatment for diseases caused by poor peripheral blood flow.
Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia (2018)

In the entire cohort, the median overall survival was 12.9 months. Among patients with a low disease burden, the median overall survival was 20.1 months and was accompanied by a markedly lower incidence of the cytokine release syndrome and neurotoxic events after 19-28z CAR T-cell infusion than was observed among patients with a higher disease burden. (Funded by the Commonwealth Foundation for Cancer Research and others; ClinicalTrials.gov number, NCT01044069 .).
α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different? (2016)

Available α1-blockers (ABs) have different profiles of receptor selectivity. Silodosin exhibits the highest selectivity for the α<sub>1A</sub> adrenergic receptor. This pharmacological feature couples with a singular urodynamic and clinical profile. The magnitude of bladder outlet obstruction improvement in patients receiving silodosin is higher if compared to other ABs. From a clinical point of view, current evidence suggests an advantage in favor of silodosin in terms of nocturia improvement and cardiovascular safety. The incidence of ejaculatory dysfunction with silodosin is higher compared to other Abs.
Broodstock management and egg and larval quality. (1995)

Red sea bream . Gilthead bream . Trout . Sturgeon . Channel catfish . African catfish . Pacific salmon . Croaker and red drum . Halibut and cod . Tilapia . Carp . Sea bass . Sperm quality . Biotechnology and genetic manipulation . Lipids . Larval foods . Cryopreservation
Self-healing of early age cracks in cement-based materials by mineralization of carbonic anhydrase microorganism (2015)

This research investigated the self-healing potential of early age cracks in cement-based materials incorporating the bacteria which can produce carbonic anhydrase. Cement-based materials specimens were pre-cracked at the age of 7, 14, 28, 60 days to study the repair ability influenced by cracking time, the width of cracks were between 0.1 and 1.0 mm to study the healing rate influenced by width of cracks. The experimental results indicated that the bacteria showed excellent repairing ability to small cracks formed at early age of 7 days, cracks below 0.4 mm was almost completely closed. The repair effect reduced with the increasing of cracking age. Cracks width influenced self-healing effectiveness significantly. The transportation of CO2and Ca(2+) controlled the self-healing process. The computer simulation analyses revealed the self-healing process and mechanism of microbiologically precipitation induced by bacteria and the depth of precipitated CaCO3 could be predicted base on valid Ca(2+).
Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family (2011)

Poly(ADP-ribose)polymerase (PARP)14--a member of the B aggressive lymphoma (BAL) family of macrodomain-containing PARPs--is an ADP ribosyltransferase that interacts with Stat6, enhances induction of certain genes by IL-4, and is expressed in B lymphocytes. We now show that IL-4 enhancement of glycolysis in B cells requires PARP14 and that this process is central to a role of PARP14 in IL-4-induced survival. Thus, enhancements of AMP-activated protein kinase activity restored both IL-4-induced glycolytic activity in Parp14(-/-) B cells and prosurvival signaling by this cytokine. Suppression of apoptosis is central to B-lymphoid oncogenesis, and elevated macro-PARP expression has been correlated with lymphoma aggressiveness. Strikingly, PARP14 deficiency delayed B lymphomagenesis and reversed the block to B-cell maturation driven by the Myc oncogene. Collectively, these findings reveal links between a mammalian ADP ribosyltransferase, cytokine-regulated metabolic activity, and apoptosis; show that PARP14 influences Myc-induced oncogenesis; and suggest that the PARP14-dependent capacity to increase cellular metabolic rates may be an important determinant of lymphoma pathobiology.
The cache performance and optimizations of blocked algorithms (1991)

article Free Access Share on The cache performance and optimizations of blocked algorithms Authors: Monica D. Lam View Profile , Edward E. Rothberg View Profile , Michael E. Wolf View Profile Authors Info & Claims ACM SIGOPS Operating Systems ReviewVolume 25Issue Special IssueApr. 1991 pp 63–74https://doi.org/10.1145/106974.106981Published:01 April 1991Publication History 704citation3,371DownloadsMetricsTotal Citations704Total Downloads3,371Last 12 Months344Last 6 weeks57 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Variable block-size transform image coder (1990)

A discrete cosine transform image coding scheme based on adaptive block size is proposed and demonstrated. The scheme adaptively optimizes the block sizes according to some local activity indexes of the image scenes. The optimization is achieved by applying the technique from graph theory. Nine rectangular block sizes are used, corresponding to all combinations of 8, 16, and 32 pixels per side. This approach reduces interblock correlation between coefficients, and increases the energy compaction in the transform domain. Experimental results are presented and compared to results obtained by an identical coder using a fixed block size.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Feeding the hungry enemy: An endothelial recipe for glioma stem cells (2011)

Comment on: Galan-Moya EM, et al. EMBO Rep 2011; 12:470-6.
Compression Properties of Methylcellulose and Hydroxypropylmethylcellulose Polymers (1999)

The compression characteristics of hydroxypropylmethylcellulose (HPMC) with different substitution levels and methylcellulose were examined using a high-speed compaction simulator. Tablet tensile strength-compression force profiles, Heckel analysis and energy analysis were evaluated.



Tablet tensile strength was affected by the polymer substitution level. In general, methylcellulose and HPMC F4M produced tablets with higher tensile strength and lower mean yield pressure, compared with HPMC K4M and HPMC E4M at all compression forces tested. These indicated the greater compressibility of methylcellulose and HPMC F4M. An increase in compression force resulted in an increase in both net compaction and elastic energy for all polymers. It was found from the specific tensile strength that more plastic energy was required for making tablets with HPMC E4M than the other polymers.
HIGH ENERGY HELIUM-ION IRRADIATION OF FORMIC ACID IN AQUEOUS SOLUTION<sup>1</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHIGH ENERGY HELIUM-ION IRRADIATION OF FORMIC ACID IN AQUEOUS SOLUTION1Warren M. Garrison, Donald C. Morrison, Herman R. Haymond, and Joseph G. HamiltonCite this: J. Am. Chem. Soc. 1952, 74, 16, 4216Publication Date (Print):August 1, 1952Publication History Published online1 May 2002Published inissue 1 August 1952https://pubs.acs.org/doi/10.1021/ja01136a518https://doi.org/10.1021/ja01136a518research-articleACS PublicationsRequest reuse permissionsArticle Views26Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Action of Adenosine Analogs on PC12 Cells (1981)

Abstract: PC12 cells, a nerve growth factor–responsive clone of rat pheochromocytoma, contain a membrane–bound adenylate cyclase, which can be activated by adenosine analogs. The characteristics of the cyclase response indicate the presence of stimulatory adenosine receptors. Adenosine analogs also produce a marked increase in the ornithine decarboxylase levels of the cells, and the characteristics of this response suggest that it is linked to the adenylate cyclase–stimulatory adenosine receptors. The ornithine decarboxylase response elicited by 5′‐ N ‐ethyIcarboxamideadenosine (NECA), a potent stimulatory adenosine analog, is synergistic with that produced by nerve growth factor. Differentiation of the cells with nerve growth factor, however, does not substantially alter either the response of cyclase to the adenosine analog or the magnitude of the adenosine–evoked ornithine decarboxylase response. Treatment of the cells with NECA produces an increase in the phosphorylation of a specific non–histone nuclear protein. While causing little or no morphological alteration by itself, NECA is synergistic with nerve growth factor in producing neurite outgrowth in PC12 cells. NECA does not cause an induction of acetylcholinesterase in the cells, nor does it appear to affect the induction of this enzyme by nerve growth factor.