gebhart/patrepeval huggingface dataset:
Gene Expression Profiling of the Early Pulmonary Response to Hyperoxia in Mice (2003)

To identify molecular events occurring during the early response to hyperoxia, we measured changes over time in total lung gene expression in C57BL/6 mice during prolonged exposure to > 95% O2. Specifically, differential gene expression of > 8,734 sequence-verified murine complementary DNAs was analyzed after 0, 8, 24, and 48 h of O2 exposure, with additional genes of interest analyzed at 24 h. Of the 385 genes differentially expressed, hyperoxia increased expression of 175 genes (2.0%) and decreased expression of 210 genes (2.3%). The majority of "classic" antioxidant enzymes, including catalase, MnSOD, and Cu-Zn SOD, showed no change in expression during hyperoxia, with a number of other antioxidant enzymes, including glutathione peroxidase, glutathione-S-Transferase (GST) Pi1, GST mu2, and heme oxygenase-1 showing relatively moderate increases. The exception was the heavy metal-binding protein metallothionein, which increased expression over 7-fold after 48 h of O2. We found no change in the expression of a number of known proinflammatory genes after 24 or 48 h of hyperoxia. A large increase in p21 expression was demonstrated, suggesting overall inhibition of cell cycle progression. Increases of the antiapoptotic gene Bcl-XL were counterbalanced by similar increases of the proapoptotic gene BAX. New findings included significant increases in expression of cysteine-rich protein 61(cyr61) at 48 h, suggesting a potential role for this factor in angiogenesis or remodeling of the extra cellular matrix during recovery from hyperoxia. In addition, downregulation of thrombomodulin expression occurred by 24 h and was further decreased at 48 h. Given the importance of thrombomodulin/thrombin interaction in regulating protein C activity, decreases in thrombomodulin may contribute to activation of the coagulation and inflammatory cascades and development of lung injury with hyperoxia.
Tensor Methods for Additive Index Models under Discordance and Heterogeneity (2018)

Motivated by the sampling problems and heterogeneity issues common in high- dimensional big datasets, we consider a class of discordant additive index models. We propose method of moments based procedures for estimating the indices of such discordant additive index models in both low and high-dimensional settings. Our estimators are based on factorizing certain moment tensors and are also applicable in the overcomplete setting, where the number of indices is more than the dimensionality of the datasets. Furthermore, we provide rates of convergence of our estimator in both high and low-dimensional setting. Establishing such results requires deriving tensor operator norm concentration inequalities that might be of independent interest. Finally, we provide simulation results supporting our theory. Our contributions extend the applicability of tensor methods for novel models in addition to making progress on understanding theoretical properties of such tensor methods.
Vision-Based Human Following and Obstacle Avoidance for an Autonomous Robot in Intersections (2012)

This paper presents an autonomous transportation robot in intersections, which could help older and disabled people go through the pedestrian crossing safely. the robot is equipped with a camera, an inertial measurement unit, encoders, etc. in this study, a single camera mounted in the front of the robot can be used to detect the region of pedestrian crossing, the obstacles and pedestrians on the pedestrian crossing. after this, the robot can determine the strategy of the obstacle avoidance or human following by using the fuzzy controller. the overall system is tested and evaluated on a university campus.
Intranasal Administration of Recombinant Mouse Interleukin‐12 Increases Inflammation and Demyelination in Chronic Experimental Autoimmune Neuritis in Lewis Rats (2000)

To examine whether interleukin (IL)-12 modulates ongoing chronic experimental autoimmune neuritis (EAN), we evaluated the effects of recombinant mouse IL-12 (rmIL-12) in Lewis rats with chronic EAN, induced by immunization with P0 peptide (180-199) plus complete Freund's adjuvant. Rats were treated intranasally with either 0.1 or 1 microg/rat/day rmIL-12 for 6 days from the onset of clinical chronic EAN, on days 5-10 postimmunization (p.i.). Only high-dose rmIL-12 exacerbated chronic EAN. This clinical effect was associated with higher numbers of inflammatory cells and more severe demyelination in sciatic nerve sections on days 15 and 80 p.i. compared with low-dose rmIL-12-treated rats and phosphate-buffered saline (PBS)-treated control rats. High-dose rmIL-12 increased significantly the lymph node mononuclear cell proliferation in response to P0 peptide 180-199 and IFN-gamma production in the sciatic nerves. These data indicate that intranasally administered IL-12 acts as a proinflammatory cytokine in chronic EAN. Effective inhibition of IL-12 in vivo could be considered for therapeutic use in chronic inflammatory demyelinating polyradiculoneuropathy.
Multipotent human breast stem cell line MCF1OAT (1996)

Human breast epithelial MCF10AT cells injected with Matrigel into the subcutis of nude/beige mice form simple ducts which, with time, resemble human proliferative breast disease and sporadically progress to carcinoma. Basement membrane was visualized with a silver stain and myoepithelial cells detected by their reactivity with antibody against smooth muscle actin. The ducts formed in situ are bilayered, composed of both myoepithelial and luminal epithelial layers circumscribed by a distinct basement membrane. The human origins of both luminal and myoepithelial layers were confirmed with fluorescent in situ hybridization with a probe for human chromosome 9. Electron microscopic studies reveal actin bundles and the formation of hemidesmosomes bordering the basement membrane, consistent with myoepithelium, as well as the formation of desmosomes between luminal and myoepithelial cells.
Buried planar and channel waveguides in sapphire and Ti:sapphire by proton implantation (2004)

Buried, stacked planar, and channel waveguides fabricated by proton implantation into sapphire are demonstrated for the first time. The good control of implantation parameters is promising to achieve active integrated optics devices Ti3+: sapphire.
Cytokine Production in Cell Culture by Peripheral Blood Mononuclear Cells from Immunocompetent Hosts (1998)

The production of interleukin 2 (IL-2) gamma interferon, IL-4, tumor necrosis factor alpha (TNF-alpha), TNF-beta, IL-5, and IL-10 in vitro by peripheral blood mononuclear cells cultured from healthy immunocompetent subjects after mitogen stimulation was determined. The mitogens used were concanavalin A, phytohemagglutinin, pokeweed mitogen, and Staphylococcus aureus Cowen. The results obtained provide a normal range for the production of these cytokines under specified conditions in vitro.
Pyridoxal Compounds as Specific Reagents for the α and β N-Termini of Hemoglobin (1973)

Bifunctional pyridoxal derivatives with a charged side chain in the 5' position react specifically with the N-terminal valine residues of hemoglobin. Three of these compounds, which have only a single negative charge in the side chain, are highly selective for the alpha-chain N-terminal residues in the oxy conformation while pyridoxal phosphate, with two negative charges, reacts specifically with the beta N-terminal in deoxyhemoglobin. Schiff's base formation, therefore, results in decreased oxygen affinity with pyridoxal phosphate but increased oxygen affinity with the other three compounds. Reduction with sodium borohydride leads to irreversible coupling at either end of the molecule, and preparation and properties of such derivatives are described.
Post‐Metalation Structural Insights into the Use of Alkali‐Metal‐Mediated Zincation for Directed <i>ortho</i>‐Metalation of a Tertiary Aromatic Amide (2006)

Catch me if you can: Invisible using standard electrophilic substitution detection methods, two distinct ortho-metalated “intermediates” generated by alkali-metal-mediated zincation of N,N-diisopropylbenzamide are structurally elucidated.
Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin (2010)

We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)] in liver homogenate and hemolysate and on the contents of cytochrome P450 in liver homogenate. It was found that doxorubicin significantly decreased the content of reduced glutathione and the total antioxidative status (FRAP) in liver homogenate and hemolysate, while celery and parsley juices alone and in combination with doxorubicin had different actions. Doxorubicin and celery juice had no effect on content of cytochrome P450. However, in combination with doxorubicin, parsley root juice significant increased, and parsley leaves juice decreased the cytochrome P450 content (compared to doxorubicin treated animals). Only parsley root juice significantly increased the content of cytochrome P450.
Small Steps: Teacher Change in a Reform Mathematics Curriculum. (2005)

An experienced mathematics teacher in a rural high school in the United States was studied as she first implemented a reform calculus curriculum. Her instruction was compared to her previous practice using a curriculum not constructed with the reform movement in mind. Despite her early attempts to make her instruction more student-centered, the teachers’ actions in the classroom were similar in many ways; demonstrating solutions to prototype problems was an important instructional strategy that she used in both curricula. However, the teacher showed an increased focus on conceptual knowledge and on the use of graphing calculator technology. The reform text was an influential part of this teacher’s change process.
Heteroalicyclic Analogs of 2- and 3-Aminoalkanethiols<sup>1,2</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeteroalicyclic Analogs of 2- and 3-Aminoalkanethiols1,2James R. Piper and Thomas P. JohnstonCite this: J. Org. Chem. 1963, 28, 4, 981–985Publication Date (Print):April 1, 1963Publication History Published online1 May 2002Published inissue 1 April 1963https://pubs.acs.org/doi/10.1021/jo01039a025https://doi.org/10.1021/jo01039a025research-articleACS PublicationsRequest reuse permissionsArticle Views271Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification of Peptides That Inhibit the DNA Binding,<i>trans</i>-Activator, and DNA Replication Functions of the Human Papillomavirus Type 11 E2 Protein (2004)

Peptide antagonists of the human papillomavirus type 11 (HPV-11) E2-DNA association were identified using a filamentous bacteriophage random peptide library. Synthetic peptides antagonized the E2-DNA interaction, effectively blocked E2-mediated transcriptional activation of a reporter gene in cell culture, and inhibited E1-E2-mediated HPV-11 DNA replication in vitro. These peptides may prove to be useful tools for characterizing E2 function and for exploring the effectiveness of E2-inhibitor-based treatments for HPV-associated diseases.
Near real‐time GPS sensing of atmospheric water vapor (1997)

We describe sensing of atmospheric column water vapor in near real‐time using the Global Positioning System (GPS). We use predicted GPS orbits for automated computation of vertical column water vapor within 30 minutes of GPS data collection. Based on a 4 month comparison, near real‐time GPS column water vapor agrees with radiosondes and radiometers within 2 mm rms. Our near real‐time column water vapor data are posted hourly at www.unavco.ucar.edu . They are available for assimilation in numerical weather models and for other applications.
Separation of polyprenol and dolichol by monolithic silica capillary column chromatography (2005)

We attempted an analysis of naturally occurring polyprenol and dolichol using a monolithic silica capillary column in HPLC. First, the separation of the polyprenol mixture alone was performed using a 250 x 0.2 mm inner diameter (ID) octadecylsilyl (ODS)-monolithic silica capillary column. The resolution of the separation between octadecaprenol (prenol 18) and nonadecaprenol (prenol 19) exceeded by >or=2-fold the level recorded when using a conventional ODS-silica particle-packed column (250 x 4.6 mm ID) under the same elution conditions. Next, the mixture of the prenol type (polyprenol) and dolichol type (dihydropolyprenol) was subjected to this capillary HPLC system, and the separation of each homolog was successfully achieved. During the analysis of polyprenol fraction derived from Eucommia ulmoides leaves, dolichols were found as a single peak, including all-trans-polyprenol and cis-polyprenol previously identified. This sensitive high-resolution system is very useful for the analysis of compounds that are structurally close to polyprenols and dolichols and that have a low content.
Double-layer silicon photonic crystal fiber tip sensor (2011)

We describe a double-layer monolithic silicon photonic crystal (PC) fiber tip sensor. The PC is fabricated using wafer-scale Si processing and epoxy bonding to the fiber. The sensor has sharper resonances and higher sensitivity to refractive index than previously-reported single-layer PC fiber tip sensors. The bonding technique enables batch production.
Regional Brain Function in Schizophrenia (1987)

Cerebral glucose metabolism was measured twice in a sample of 15 schizophrenics and eight controls, using positron emission tomography (PET) with 18-F-fluorodeoxyglucose. Studies were separated by three to 33 weeks. Patients were unmedicated during the first study, and the majority were receiving neuroleptics during the second study. There were no changes from study 1 to study 2 in average whole-brain metabolic rates, regional cortical activity, or the gradient of subcortical to cortical activity. The steeper subcortical to cortical gradient in schizophrenics, present in the first study, persisted in the second. Changes in this gradient were uncorrelated with changes in clinical status. Laterality (right-left) was stable across studies, and changes toward higher right relative to left hemispheric metabolism were correlated with clinical improvement. The results support the hypothesis of abnormal hemispheric activity in schizophrenia and implicate the subcortical-cortical gradient as another dimension that merits further exploration.
One-Step Direct Transfer of Pristine Single-Walled Carbon Nanotubes for Functional Nanoelectronics (2010)

We report a one-step direct transfer technique for the fabrication of functional nanoelectronic devices using pristine single-walled carbon nanotubes (SWNTs). Suspended SWNTs grown by the chemical vapor deposition (CVD) method are aligned and directly transferred onto prepatterned device electrodes at ambient temperature. Using this technique, we successfully fabricated SWNT electromechanical resonators with gate-tunable resonance frequencies. A fully suspended SWNT p-n diode has also been demonstrated with the diode ideality factor equal to 1. Our method eliminates the organic residues on SWNTs resulting from conventional lithography and solution processing. The results open up opportunities for the fundamental study of electron transport physics in ultraclean SWNTs and for room temperature fabrication of novel functional devices based on pristine SWNTs.
Nonlinear harmonic generation in free-electron lasers (2000)

A three-dimensional nonlinear simulation code to treat multiple frequencies simultaneously is described and used to study nonlinear harmonic generation in free-electron lasers (FELs). Strong nonlinear harmonic gain is found where the gain length varies inversely with the harmonic number. Substantial power levels are found in the harmonics. The odd harmonics are favored with generally higher power levels since a planar wiggler geometry is employed; however, the second harmonic exhibits substantial power as well. The analysis is relevant to the emission expected from self-amplified spontaneous emission (SASE) free-electron laser schemes.
Context-based image modelling (2003)

In this work we address the task of adapting the model representation of a given image, in the context of a second target image model. We present the BlobEMD framework, in which the images are represented as sets of blobs, and optimal correspondences are found between the representations of the images and are used to adapt the representation of the source image to that of the target image. The context-based model adaptation allows for similarity measures between images that are insensitive to the segmentation process and different levels of details of the representation. We show applications for matching models of heavily dithered images with models of full resolution images, and for content-based image segmentation where the transition from regions to representative silhouettes is shown.
ChemInform Abstract: USE OF (S)‐(TRIFLOXYMETHYL)OXIRANE IN THE SYNTHESIS OF A CHIRAL β‐ADRENOCEPTOR ANTAGONIST, (R)‐ AND (S)‐9‐((3‐(TERT‐BUTYLAMINO)‐2‐HYDROXYPROPYL)OXIMINO)FLUORENE (1983)

Abstract Das Monotosylat (I) ergibt über das (R)‐Oxiran (II) den Trifluormethansulfonsäure‐ester (III), der mit Fluorenonoxim (IV) zum Derivat (V) umgesetzt wird.
Applications Of Advanced "Z" Technology Focal Plane Architectures (1988)

Z Technology FPA architectures provide an essential advantage over planar technologies: electronics real estate for processing individual detector signals. Originally developed for staring surveillance sensors, the Z architecture is now being applied to many other applications with additional ones to follow in the near future. After a description and background of Z technology are reviewed, examples of various military and civilian applications are discussed.
Self-securing ad hoc wireless networks (2003)

Mobile ad hoc networking offers convenient infrastructureless communication over the shared wireless channel. However, the nature of ad hoc networks makes them vulnerable to security attacks. Examples of such attacks include passive eavesdropping over the wireless channel, denial of service attacks by malicious nodes and attacks from compromised nodes or stolen devices. Unlike their wired counterpart, infrastructureless ad hoc networks do not have a clear line of defense, and every node must be prepared for encounters with an adversary. Therefore, a centralized or hierarchical network security solution does not work well.This work provides scalable, distributed authentication services in ad hoc networks. Our design takes a self-securing approach, in which multiple nodes (say, k) collaboratively provide authentication services for other nodes in the network. We first formalize a localized trust model that lays the foundation for the design. We further propose refined localized certification services based on our previous work, and develop a new scalable share update to resist more powerful adversaries. Finally, we evaluate the solution through simulation and implementation.
Large-scale concentration and purification of virus suspension from microcarrier culture for the preparation of inactivated virus vaccines. (1979)

Because of the presence of bovine serum proteins in poliovirus and rabiesvirus suspensions harvested from microcarrier cultures, a concentration and purification process has been developed in order to remove these proteins. The process comprises clarification by filtration, concentration by ultrafiltration, gel filtration on Sepharose 6B and column chromatography on DEAE-Sephadex A50. The serum protein content of the virus suspensions if reduced to a serum dilution of less than 1: 10(6) at a virus antigen recovery rate of 70 to 80%.
Restructuring critical care services. Part III: Successful implementation preparation. (1996)

Successful implementation in a redesigning organization does not happen without a sound design, good implementation planning and effective leadership. The focus of the implementation preparation must change prior to and after the "go live" implementation date. Implementation preparation requires intentional steps to build systems, communicate effectively and develop operational understanding among clinicians, physicians and management. Early effort should focus on planning for efficient day-to-day operations, development of measurement systems and contingency planning. Immediately prior to and after implementation the focus should be on communication, goal setting, issues prioritization and fact-based issues resolution. After the first couple of months of implementation, the focus should move toward mentoring teams/individuals, building outcome measurement systems, identifying sources of future improvement and transferring more authority as appropriate to teams. Commit to comprehensive implementation preparation. Time spent on implementation preparation will pay large dividends during the challenging times of transitioning your organization to a redesigned world.
Recent Advances in Anti-cancer Protein/Peptide Delivery (2018)

Protein/peptide drugs possess unique advantages, such as high pharmacological potency, molecular specificity, multifunctionality, and low toxicity, and thus hold great potential for use in cancer therapy. In the past decades, great achievements have been made in protein delivery systems, which can protect cargo proteins against detrimental physiological environments and efficiently deliver proteins into tumor sites and cells. In this Review, we first summarize the existing protein/peptide drugs used for cancer treatment, illustrate their anti-tumor mechanisms, and point out the potential challenges/barriers against their medical utility. We then discuss the existing strategies for protein encapsulation/conjugation and survey recent advances in the development of protein delivery vehicles, including lipid-based membrane nanocarriers, polymeric carriers, metal-organic frameworks, inorganic carriers, protein/peptide-based nanocarriers, and DNA nanostructures. The design strategies, advantages in potentiating protein delivery efficiencies, and possible limitations of these delivery systems are also discussed. Finally, future opportunities and challenges in anti-cancer protein/peptide delivery are indicated.