gebhart/patrepeval huggingface dataset:
Anti-inflammatory and Analgesic Activity of<i>Uraria lagopoides</i> (2004)

Anti-inflammatory activity of alcohol and aqueous extract of aerial parts of Uraria lagopoides was determined in the rat paw edema test.At doses of 100 and 200 mg/kg, oral, the extract inhibited edema significantly (p < 0.01) compared with indomethacin (20 mg/kg).It also showed marked analgesic activity in mice (p < 0.01), compared with acetylsalicylic acid (100 mg/kg) in acetic acid-induced writhing test.
Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl- 2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the rat. (1994)

The gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl)-7- phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid (ML 3000, CAS 156897-06-2) has been tested in comparison with indometacin, after both single and multiple administrations for 5 and 11 days in an in vivo rat assay. A single oral administration of ML 3000 at doses of 10, 30 and 100 mg/kg produced no gastrointestinal damage. Repeated oral administration of ML 3000 at daily doses of 10, 30 and 100 mg/kg produced slight gastrointestinal damage, but the effect was minimal and was not found to be statistically significant. Indometacin produced highly statistically significant gastric and duodenal damage following one single administration of 10 mg/kg. Repeated oral administration, at 3 mg/kg each day, produced moderate and statistically significant gastric and slight duodenal damage on Day 5 of dosing. However, by Day 11 pronounced duodenal damage was observed which was shown to be statistically highly significant. These results indicate that ML 3000 is clearly better tolerated by the gastrointestinal tract than indometacin after single and multiple administration up to 11 days in rats.
ChemInform Abstract: SYNTHESIS, CATION BINDING, AND PHOTOPHYSICAL PROPERTIES OF MACROBICYCLIC ANTHRACENOCRYPTANDS (1985)

Abstract Die aus dem makrocyclischen Diamin (II) zugänglichen Anthracen‐ überbrückten Kryptanden (III) bilden mit K′? und Tltlonen 1:1‐Komplexe.
GTE SuperPages: Using IR Techniques for Searching Complex Objects (1997)

The yellow pages service of GTE SuperPages enables Web users to flexibly search through liitings of 11 million businesses in over 17000 categories. To achieve the flexibility desired it uses an Information Retrieval (IR) engine to search through complex listing objects. The objects themselves are stored in an object database. The use of the IR engine enables us to create an index that spans all the components of a complex object.
Depth-enhanced compression for 3D video (2011)

The original idea of the paper is to exploit depth maps in order to increase compression efficiency for multiview video. Depth information is used to establish a 3D mapping between each pixel in an encoded frame and its counterpart in the reference view. With this mapping motion vectors and reference frame indices can be obtained independently for each pixel in a coded picture by a simple derivation of the motion information assigned to the corresponding pixel in the reference view. The goal of the paper is to explore a practical way to use this idea in multiview video coding. This goal has been achieved by experimental testing of various sets of direct and skip modes with and without inter-frame motion prediction. It was shown that either “all modes” have to be used or “all but not classic direct mode” should be used. The respective experimental results have been provided in the paper.
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating <i>Mycobacterium tuberculosis</i> (2008)

The persistence of Mycobacterium tuberculosis despite prolonged chemotherapy represents a major obstacle for the control of tuberculosis. The mechanisms used by Mtb to persist in a quiescent state are largely unknown. Chemical genetic and genetic approaches were used here to study the physiology of hypoxic nonreplicating mycobacteria. We found that the intracellular concentration of ATP is five to six times lower in hypoxic nonreplicating Mtb cells compared with aerobic replicating bacteria, making them exquisitely sensitive to any further depletion. We show that de novo ATP synthesis is essential for the viability of hypoxic nonreplicating mycobacteria, requiring the cytoplasmic membrane to be fully energized. In addition, the anaerobic electron transport chain was demonstrated to be necessary for the generation of the protonmotive force. Surprisingly, the alternate ndh-2, but not -1, was shown to be the electron donor to the electron transport chain and to be essential to replenish the [NAD(+)] pool in hypoxic nonreplicating Mtb. Finally, we describe here the high bactericidal activity of the F(0)F(1) ATP synthase inhibitor R207910 on hypoxic nonreplicating bacteria, supporting the potential of this drug candidate for shortening the time of tuberculosis therapy.
Fluorine Containing Bioactive Heterocycles. Part III: Synthesis of Some New Fluorine Containing Phenylglyoxals and 1,2,4-Triazine Derivatives (1981)

a c t -Some medicinally important new f l u o r i n e containing phenylglyoxals have been synthesized by selenium dioxide oxidation of appropriate f l u o r i n a t e d acetoFhenones and charact e r i z e d by s p e c t r a l studies.'the phenylglyoxals were t r e a t e d with thiosemicarbazide t o g i v e corresponding Wiosemicarbazones (111) w h i m were cyclized, i n sit", t o yield 5-(fluoropheny1)- 1.2,btriazine-3(M_)-thiones.I h e 5-(4-fluorophenyl )-I ,2,4- triazine-3-(=I-thione(IV)undergoes nucleophilic displacement when refluxed with hydrazine hydrate t o give corresponding
Neural Network Communications Signal Processing (1994)

This final technical report describes the research and development- results of the Neural Network Communications Signal Processing (NNCSP) Program. The objectives of the NNCSP program are to: (1) develop and implement a neural network and communications signal processing simulation system for the purpose of exploring the applicability of neural network technology to communications signal processing; (2) demonstrate several configurations of the simulation to illustrate the system's ability to model many types of neural network based communications systems; and (3) use the simulation to identify the neural network configurations to be included in the conceptual design of a neural network transceiver that could be implemented in a follow-on program. Neural networks, Signal processing, Communications
Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential (2010)

J. Neurochem. (2011) 116, 10–21. Ectodomain shedding of the amyloid precursor protein (APP) by the metalloprotease activity α-secretase is a key regulatory event preventing the generation of the Alzheimer’s disease (AD) amyloid β peptide. Proteases similar to α-secretase are essential for diverse physiological processes, such as embryonic development, cell adhesion and neuronal guidance. Previously, several proteases were suggested as candidate α-secretases for APP, in particular members of the ADAM family (a disintegrin and metalloprotease). Two recent studies analyzed primary neurons, which are the cell type affected in AD, and finally demonstrated that the constitutively cleaving α-secretase activity is selectively mediated by ADAM10. An increase in α-secretase cleavage is considered a therapeutic approach for AD. However, the molecular mechanisms regulating α-secretase cleavage remain only partly understood. Signaling pathways activating protein kinase C and MAP kinase play a central role in stimulating α-secretase cleavage of APP. Additionally, several recent publications demonstrate that ADAM10 expression and α-secretase cleavage of APP are tightly controlled at the level of transcription, e.g. by retinoic acid receptors and sirtuins, and at the level of translation and protein trafficking. This review focuses on the recent progress made in unraveling the molecular identity, regulation and therapeutic potential of α-secretase in Alzheimer’s disease.
pH induced interaction of DPPC with a fluorescent dye in Langmuir and Langmuir Blodgett (LB) films (2017)

This communication reports the investigation of the pH effects on the interaction of a well-known lung surfactant, Dipalmitoylphosphatidylcholine (DPPC) with water soluble highly fluorescent dye Rhodamine B (RhB) in complex Langmuir monolayers at the air–water interface. The ionic nature of DPPC changes with the pH of the subphase in the Langmuir trough. At sufficiently low pH it becomes cationic whereas at higher pH it can be presented with a negative net charge and at normal pH it is zwitterionic. Being zwitterionic, RhB molecules can interact with DPPC at normal and higher pH, whereas at lower pH the interaction becomes less probable. This has been investigated in details at the air–water interface in Langmuir trough as well as in Langmuir Blodgett (LB) film by employing surface pressure versus area per molecule (π–A) isotherms, compressibility study, in-situ Fluorescence Imaging Microscopy (FIM), UV-vis absorption spectroscopy and Atomic Force Microscopy (AFM) study.
License plate extraction and recognition of a Thai vehicle based on MSER and BPNN (2015)

The extraction and recognition of a Thai vehicle license plate based on Maximally Stable Extremal Regions (MSER) and Back-Propagation Neural Network (BPNN) is presented. The license plate area is in a maximally stable extremal region of a car image. It can be effectively extracted from MSERs by multiple classifications. The feature extraction of characters from the license plate is based on Zernike moment. The feature is used as a training dataset for the BPNN to recognize the characters. The experimental results indicate that the proposed approach is an effective method for the extraction and recognition of a Thai license plate.
Evidence for Preorganization of the <i>glmS</i> Ribozyme Ligand Binding Pocket (2006)

We have examined the tertiary structure of the ligand-activated glmS ribozyme by a combination of methods with the aim of evaluating the magnitude of RNA conformational change induced by binding of the cofactor, glucosamine 6-phosphate (GlcN6P). Hydroxyl radical footprinting of a trans-acting ribozyme complex identifies several sites of solvent protection upon incubation of the RNA in Mg(2+)-containing solutions, providing initial evidence of the tertiary fold of the ribozyme. Under these folding conditions and at GlcN6P concentrations that saturate the ligand-induced cleavage reaction, we do not observe changes to this pattern. Cross-linking with short-wave UV light of the complex yielded similar overall results. In addition, ribozyme-substrate complexes cross-linked in the absence of GlcN6P could be gel purified and then activated in the presence of ligand. One of these active cross-linked species links the base immediately 3' of the cleavage site to a highly conserved region of the ribozyme core and could be catalytically activated by ligand. Combined with recent studies that argue that GlcN6P acts as a coenzyme in the reaction, our data point to a riboswitch mechanism in which ligand binds to a prefolded active site pocket and assists in catalysis via a direct participation in the reaction chemistry, the local influence on the geometry of the active site constituents, or a combination of both mechanisms. This mode of action is different from that observed for other riboswitches characterized to date, which act by inducing secondary and tertiary structure changes.
Eigenspace Adaptive Filtering For Efficient Pre-Equalization Of Acoustic Mimo Systems (2006)

Publication in the conference proceedings of EUSIPCO, Florence, Italy, 2006
Bias Mitigation Post-processing for Individual and Group Fairness (2018)

Whereas previous post-processing approaches for increasing the fairness of predictions of biased classifiers address only group fairness, we propose a method for increasing both individual and group fairness. Our novel framework includes an individual bias detector used to prioritize data samples in a bias mitigation algorithm aiming to improve the group fairness measure of disparate impact. We show superior performance to previous work in the combination of classification accuracy, individual fairness and group fairness on several real-world datasets in applications such as credit, employment, and criminal justice.
Scale-Up of a Chiral Resolution Using Cross-Linked Enzyme Crystals (1998)

The scale-up of a biocatalytic process using a cross-linked enzyme crystal (ChiroCLEC-PC, Altus Biologics Inc., Cambridge, MA) for the resolution of a racemic mixture (R/S-sec-phenethyl acetate to R-sec-phenethyl alcohol) is reported. Reaction parameters were initially investigated at the 20-mL and 1-L scale to determine optimum reactor conditions for operation at the 100-L scale. At this scale, reproducibility trials were conducted with a single charge of 50 g of ChiroCLEC-PC for the entire nine trials. Results demonstrated that, although there was a steady decrease in reaction rate over the trials (primarily as a result of sub-optimal CLEC catalyst recovery between each trial) all nine reactions proceeded to >48% conversion, with eep's of 99.9% and ees's of 91−95% recorded. In total, 270 kg of racemate was converted into R-phenethyl alcohol and S-phenethyl acetate during the reproducibility trials using a standard stirred tank design with pH control. With further work to improve CLEC catalyst recovery between runs, the technology is suitable for industrial exploitation to compete favourably alongside alternative chiral technologies.
High-efficiency fluorescent organic light-emitting diodes with MoO<sub>3</sub> and PEDOT : PSS composition film as a hole injection layer (2014)

The high efficiency and low efficiency roll-off can be achieved in C545T-based green OLEDs with MoO3/PEDOT : PSS as the interfacial modification layer on ITO.
Highly Efficient Ligation of Small RNA Molecules for MicroRNA Quantitation by High-Throughput Sequencing (2014)

MiRNA cloning and high-throughput sequencing, termed miR-Seq, stands alone as a transcriptome-wide approach to quantify miRNAs with single nucleotide resolution. This technique captures miRNAs by attaching 3' and 5' oligonucleotide adapters to miRNA molecules and allows de novo miRNA discovery. Coupling with powerful next-generation sequencing platforms, miR-Seq has been instrumental in the study of miRNA biology. However, significant biases introduced by oligonucleotide ligation steps have prevented miR-Seq from being employed as an accurate quantitation tool. Previous studies demonstrate that biases in current miR-Seq methods often lead to inaccurate miRNA quantification with errors up to 1,000-fold for some miRNAs. To resolve these biases imparted by RNA ligation, we have developed a small RNA ligation method that results in ligation efficiencies of over 95% for both 3' and 5' ligation steps. Benchmarking this improved library construction method using equimolar or differentially mixed synthetic miRNAs, consistently yields reads numbers with less than two-fold deviation from the expected value. Furthermore, this high-efficiency miR-Seq method permits accurate genome-wide miRNA profiling from in vivo total RNA samples.
Categorization of image databases for efficient retrieval using robust mixture decomposition (2002)

The authors present a robust mixture decomposition technique that automatically finds a compact representation of the data in terms of categories, and apply it to the problem of organizing databases for efficient retrieval. The time taken for retrieval is shown to be an order of magnitude smaller than that of exhaustive search methods. The proposed scheme is tested on images from the VisTex texture image database.
Mechanism of addition of singlet oxygen to olefins and other substrates (1971)

Abstract
What Competitive Approach Will Be More Practical to Small and Medium Sized Tourism Enterprises (2007)

In the search for sustainable competitive advantage, managing knowledge is critical not only for large organisations but also for Small and Medium sized Tourism Enterprises (SMTEs) where limited resources and the lack of the strategic direction are prevalent. Findings from the literature review suggest that, in relative terms, SMTEs are less ready for implementing knowledge management projects than are large organisations. It is also suggested that SMTEs are in need of practical strategic guidance if they are to make the most of the, often under-exploited, knowledge within and available to their organisations. For the support of SMTEs' initial needs for knowledge management, this paper proposes a strategy aimed at harnessing explicit knowledge and strategic activities based on an extensive analysis of the literature. The proposed strategy contains actionable steps that can be implemented and modified iteratively by SMTEs, with in-built assessment and measurement mechanisms.
Membrane Permeabilization: A Common Mechanism in Protein-Misfolding Diseases (2005)

Protein aggregation--and, more specifically, amyloid fibril formation--has been implicated as a primary cause of neurodegeneration in Alzheimer's disease, Parkinson's disease, and related disorders, but the mechanism by which this process triggers neuronal death is unknown. Mounting evidence from in vitro studies, cell culture, and animal models of these diseases supports the hypothesis that a structural intermediate on the pathway to fibril formation, rather than amyloid fibrils themselves, may be the pathogenic species. Characterization of these intermediates in solution or upon interactions with membranes indicate that these intermediates form pores and suggests that neurons could be killed by unregulated membrane permeabilization caused by such "amyloid pores."
Fluoroquinolone-resistant Pseudomonas aeruginosa: risk factors for acquisition and impact on outcomes (2005)

FQ exposure from widespread prescribing is a modifiable risk factor for FQ resistance in P. aeruginosa. FQ empirical therapy for Pseudomonas infections may be associated with significant delays in administering effective therapy resulting in adverse outcomes.
Vulvovaginal Complaints (2008)

Overview of the etiology and diagnostic evaluation of vulvovaginal complaints in the postmenopausal population including both estrogen's role in atrophic vaginitis and other causes of vulvovaginal complaints and how they relate to sexual function. Summary of various management options such as hormonal, nonhormonal, and botanical interventions.
Molecular basis of congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency. (1993)

Congenital adrenal hyperplasia is the most frequent cause of adrenal insufficiency and ambiguous genitalia in newborn children. In contrast to congenital adrenal hyperplasia due to 21-hydroxylase and 11 beta-hydroxylase deficiencies, which impair steroid formation in the adrenal cortex, exclusively, classical 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) deficiency affects steroid biosynthesis in the gonads as well as in the adrenals. The structures of the highly homologous type I and II 3 beta-HSD genes have been analyzed in three male pseudohermaphrodite 3 beta-HSD deficient patients from unrelated families in order to elucidate the molecular basis of classical 3 beta-HSD deficiency from patients exhibiting various degrees of severity of salt losing. The nucleotide sequence of DNA fragments generated by selective polymerase chain reaction amplification that span the four exons, the exon-intron boundaries, as well as the 5'-flanking region of each of the two 3 beta-HSD genes have been determined in the three male patients. The five point mutations characterized were all detected in the type II 3 beta-HSD gene, which is the gene predominantly expressed in the adrenals and gonads, while no mutation was detected in the type I 3 beta-HSD gene, predominantly expressed in the placenta and peripheral tissues. The two male patients suffering from severe salt-losing 3 beta-HSD deficiency are compound heterozygotes, one bearing the frame-shift mutation 186/insC/187 and the missense mutation Y253N, while the other bears the nonsense mutation W171X and the missense mutation E142K. The influence of the detected missense mutations on enzymatic activity was assessed by in vitro expression analysis of mutant recombinant enzymes generated by site-directed mutagenesis in heterologous mammalian cells. Recombinant mutant type II 3 beta-HSD enzymes carrying Y253N or E142K substitutions exhibit no detectable activity. On the other hand, the nonsalt-losing patient is homozygous for the missense mutation A245P. This mutation decreases 3 beta-HSD activity by approximately 90%. The present findings, describing the first missense mutations in the human type II 3 beta-HSD gene, provide unique information on the structure-activity relationships of the 3 beta-HSD superfamily. Moreover, the present findings provide a molecular explanation for the enzymatic heterogeneity responsible for the severe salt-losing form to the clinically inapparent salt-wasting form of classical 3 beta-HSD deficiency.(ABSTRACT TRUNCATED AT 400 WORDS)
Enlargement of Poly-Si Film Grain Size by Excimer Laser Annealing and Its Application to High-Performance Poly-Si Thin Film Transistor (1991)

By both numerical simulation and experimental investigation, we found it possible to enlarge the grain size (∼3000 Å) of polycrystalline silicon (poly-Si) films by excimer laser annealing, using a new method to control the solidification process of molten Si - low-temperature (≦400°C) substrate heating during laser annealing. Poly-Si thin-film transistors (TFTs) fabricated by this new excimer laser annealing method showed a high field-effect mobility of 230 cm 2 /V·s, and good uniformity of field-effect mobility (±10%) within the effective laser irradiation area.
Manufacturing Process Technology (2011)

This special volume aims to bring together the latest advances in, and applications of, surface engineering/coatings, modeling, analysis and simulation, materials forming, materials machining, welding and joining, laser-processing technology, casting and solidification, precision manufacturing technology and measurements, etc. It will not only furnish readers with a broad overview of the latest advances, but also provide a valuable summary and reference work for researchers in this field.
Determination of the Quadrupole Coupling Constant of the Invisible Aluminum Spins in Zeolite HY with 1H/27Al TRAPDOR NMR (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of the Quadrupole Coupling Constant of the Invisible Aluminum Spins in Zeolite HY with 1H/27Al TRAPDOR NMRClare P. Grey and Alexander J. VegaCite this: J. Am. Chem. Soc. 1995, 117, 31, 8232–8242Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/ja00136a022https://doi.org/10.1021/ja00136a022research-articleACS PublicationsRequest reuse permissionsArticle Views1710Altmetric-Citations328LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts