gebhart/patrepeval huggingface dataset:
Lack of effect of warfarin on the restenosis rate or on clinical outcome after balloon coronary angioplasty. (1988)

Between September 1985 and April 1987, 110 consecutive patients who had successful coronary angioplasty were included in a randomised prospective controlled evaluation of the effects of warfarin on restenosis. The warfarin (n = 56) and the control (n = 54) groups were not different in terms of age, sex, previous coronary bypass surgery or coronary balloon angioplasty, severity of symptoms, and frequency of multivessel disease or of total coronary occlusions. Warfarin was started on the day of the procedure and the dosage was adjusted to maintain the thromboplastin international normalised ratio greater than or equal to 2.5. One hundred and five (96%) of the patients were given verapamil and other antianginal drugs were prescribed as needed. Low molecular weight dextran and heparin were given during the procedure and heparin was continued for 24 hours in all patients. One hundred and eight (98%) of patients were followed up clinically after a median of five months (range 1-20). Eighty five (77%) had follow up angiography at five months. In the warfarin group symptoms improved in 46 (85%) patients by at least 1 angina class and 31 (57%) were symptom free; the exercise test remained positive in 20 (36%) patients and the angiographic restenosis rate was 25% per lesion and 29% per patient. There were no major bleeding complications. In the control group 46 (85%) patients were improved by at least 1 angina class and 31 (57%) were symptom free; the exercise test was positive in 11 (21%) patients and the angiographic restenosis rate was 33% per lesion and 37% per patient. Although the incidence of angiographic restenosis tended to be lower with warfarin, none of these differences was significant. These data suggest that the combination of verapamil and warfarin, in the absence of aspirin, is not significantly better than verapamil alone in preventing symptom recurrence or angiographic restenosis after coronary angioplasty.
Targets for Microwave Radar Navigation (1947)

The effective echoing areas of certain radar targets can be calculated by the methods of geometrical optics. Other more complicated structures have been investigated experimentally. This paper considers a number of targets of practical interest with particular emphasis on trihedral and biconical comer reflectors. The possibility is indicated of using especially designed targets of high efficiency as aids to radar navigation.
Filth, Filtering, and the First Amendment: Ruminations on Public Libraries' Use of Internet Filtering Software (2001)

Traditionally, whenever the government has sought to regulate speech, analysis of its action focused on conventional issues, such as the type of forum involved, whether the government acted in a regulatory or a proprietary role, and whether the regulation could be defined as a prior restraint. With the advent of the Internet and the opportunity for the widespread dissemination of viewpoints, however, new issues have arisen. This Article focuses on the complex questions public libraries face when filtering material, usually of a sexually explicit nature, from the public using filtering software. This Article contends that public libraries require a unique analysis because they represent the government by facilitating access to speech. With this in mind, this Article discusses several arguments for and against the use of filtering software, and concludes that public libraries should be able to employ such tools, but, at the same time, meet certain requirements in their implementation.
Development of an HDD Spindle Motor With Increased Stiffness and Damping Coefficients by Utilizing a Stationary Permanent Magnet (2007)

This research proposes a novel design of a hard-disk-drive spindle motor with increased stiffness and damping coefficients. It has the permanent magnet in the sleeve, which generates the stationary attractive magnetic force. It results in the static eccentricity of the rotating spindle, which increases the stiffness and damping effect of fluid dynamic bearings. The performance of the proposed design is verified by the experiment, as well as by the numerical simulation. The experiment shows that the proposed design decreases the nonrepeatable vibration by 10% when the eccentricity increases by 0.2 mum in the given motor
Countermeasures for the Simple Branch Prediction Analysis. (2006)

Branch Prediction Analysis has been proposed as an attack method to obtain key bits from a cryptographic application. In this report, we put forth several solutions to avoid or prevent this attack. The reported countermeasures require only minimal hardware support that is commonly available in modern superscalar processors. 1
Targeting Intracellular Pathogenic Bacteria with Unnatural Proline‐Rich Peptides: Coupling Antibacterial Activity with Macrophage Penetration (2013)

De novo design of unnatural proline-rich peptides led to a potent antibacterial peptide that targets both Gram-positive and -negative bacteria. The peptide exerts activity without lysing bacterial membranes or causing hemolysis, and is stable to extended trypsin treatment. Facile entry into macrophages was observed, leading to extensive intracellular clearing of pathogenic bacteria. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
GLIDER gradient landmark-based distributed routing for sensor networks (2005)

We present gradient landmark-based distributed routing (GLIDER), a novel naming/addressing scheme and associated routing algorithm, for a network of wireless communicating nodes. We assume that the nodes are fixed (though their geographic locations are not necessarily known), and that each node can communicate wirelessly with some of its geographic neighbors - a common scenario in sensor networks. We develop a protocol which in a preprocessing phase discovers the global topology of the sensor field and, as a byproduct, partitions the nodes into routable tiles - regions where the node placement is sufficiently dense and regular that local greedy methods can work well. Such global topology includes not just connectivity but also higher order topological features, such as the presence of holes. We address each node by the name of the tile containing it and a set of local coordinates derived from connectivity graph distances between the node and certain landmark nodes associated with its own and neighboring tiles. We use the tile adjacency graph for global route planning and the local coordinates for realizing actual inter- and intra-tile routes. We show that efficient load-balanced global routing can be implemented quite simply using such a scheme.
Blends of polyamide 6 and bisphenol‐A polycarbonate. Effects of interchange reactions on morphology and mechanical properties (1992)

Abstract Blends of polyamide 6 (PA6) and polycarbonate (PC) were prepared in a Brabender mixer, at 240°C, applying long mixing time, for 45 min. It was observed that the morphology and the mechanical properties tend to resemble those of a homogeneous material as the mixing time and PA6 concentration increase. This is attributed to chemical reactions taking place between the two homopolymers. Acidolysis, amidolysis, and aminolysis, catalyzed by the terminals and the amide groups of the polyamide, should in principle be possible. Our results indicate that the aminolysis is the main process, inducing simultaneously scission of PC chains and formation of PC‐PA6 copolymer chains. The latter act as interfacial agents between incompatible PA6 and PC, improving the mechanical properties of PA6‐rich blends, in agreement with the predictions of some theoretical models assuming good phase interpenetration. © 1992 John Wiley & Sons, Inc.
Sampling sea surfaces with SESAMO: an autonomous craft for the study of sea-air interactions (2005)

This paper presents the system design, sea trials and Antartic exploitation of the SESAMO platform. The SESAMO (sea surface autonomous modular unit) prototype robot was especially designed to collect data and samples for the study of the sea-air interface. At sea, operations showed that a relatively simple robot could satisfactorily work in a natural, outdoor environment, dramatically facilitating the job of the human operator. To achieve high quality sampling of the surface microlayer, however, requires a large amount of time, leading to significant demands on logistics resources, mainly in terms of operating time of the support vessel.
Electro-optical behaviour of ferroelectric liquid crystal (FLC) mixtures (2003)

In combination with the fabrication technique and the driving electronics, material parameters determine the static and dynamic director configuration and, therefore, the electrooptical behavior of the surface-stabilized ferroelectric liquid crystal (FLC) display (SSFLC), a promising technique for applications which require video frame rate and high spatial resolution, such as TV and computer monitors. The authors describe another important parameter, which is the type of texture that is induced by the application of AC electric fields. It is shown that the smectic layer structure of the display and thus its texture are irreversibly changed by exceeding a critical AC field amplitude that depends on the frequency, the temperature, and some material properties. In the altered textures the same FLC material exhibits strikingly different electrooptical properties.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Overproduction, Purification, and Characterization of the XPC Subunit of the Human DNA Repair Excision Nuclease (1996)

Xeroderma pigmentosum complementation group C gene (XPC) encodes a protein of 125 kDa which is present in a tight complex with a 58-kDa protein encoded by the human homolog of the yeast RAD23 gene, HHR23B (Masutani, C., Sugasawa, K., Yanagisawa, J., Sonoyama, T., Ui, M., Enomoto, T., Takio, K., Tanaka, K., van der Spek, P. J., Bootsma, D., Hoeijmakers, J. H. J., and Hanaoka, F.(1994) EMBO J. 13, 1831-1843). The XPC-HHR23B complex is required for excision of thymine dimers from DNA in a human excision nuclease system reconstituted from purified proteins. In order to understand the role of the XPC-HHR23B complex in excision repair, we have overexpressed each subunit alone and the heterodimer in heterologous systems, purified them, and characterized their biochemical properties. We find that both XPC and the heterodimer bind DNA with high affinity and UV-damaged DNA with slightly higher preference. Surprisingly, we find that the XPC subunit alone is sufficient for reconstitution of the human excision nuclease and that the HHR23B subunit has no detectable effect on the excision activity of the reconstituted system.
Lactones in foods (1976)

Lactones represent another important class of flavor compounds that have been found in a wide variety of foods although traditionally they have been mainly associated with dairy products. This review summarizes their occurrences in foods along with their formation pathways, sensory properties, and isolation, identification, and synthesis techniques specific to lactones associated with food flavor.
Lightweight implementation of the POSIX threads API for an on-chip MIPS multiprocessor with VCI interconnect (2003)

This paper relates our experience in designing from scratch a multi-threaded kernel for a MIPS R3000 on-chip multiprocessor. We briefly present the target architecture build around a VCI compliant interconnect, and the CPU characteristics. Then we focus on the implementation of part of the POSIX 1003.1b and 1003.1c standards. We conclude this case study by simulation results obtained by cycle true simulation of an MJPEG video decoder application on the multiprocessor using several scheduler organizations and architectural parameters.
Molecular Cloning and Functional Expression in <i>Lactobacillus plantarum</i> 80 of <i>xylT</i> , Encoding the <scp>d</scp> -Xylose–H <sup>+</sup> Symporter of <i>Lactobacillus brevis</i> (1998)

A 3-kb region, located downstream of the Lactobacillus brevis xylA gene (encoding D-xylose isomerase), was cloned in Escherichia coli TG1. The sequence revealed two open reading frames which could code for the D-xylulose kinase gene (xylB) and another gene (xylT) encoding a protein of 457 amino acids with significant similarity to the D-xylose-H+ symporters of E. coli, XylE (57%), and Bacillus megaterium, XylT (58%), to the D-xylose-Na+ symporter of Tetragenococcus halophila, XylE (57%), and to the L-arabinose-H+ symporter of E. coli, AraE (60%). The L. brevis xylABT genes showed an arrangement similar to that of the B. megaterium xylABT operon and the T. halophila xylABE operon. Southern hybridization performed with the Lactobacillus pentosus xylR gene (encoding the D-xylose repressor protein) as a probe revealed the existence of a xylR homologue in L. brevis which is not located with the xyABT locus. The existence of a functional XylR was further suggested by the presence of xylO sequences upstream of xylA and xylT and by the requirement of D-xylose for the induction of D-xylose isomerase, D-xylulose kinase, and D-xylose transport activities in L. brevis. When L. brevis was cultivated in a mixture of D-glucose and D-xylose, the D-xylose isomerase and D-xylulose kinase activities were reduced fourfold and the D-xylose transport activity was reduced by sixfold, suggesting catabolite repression by D-glucose of D-xylose assimilation. The xylT gene was functionally expressed in Lactobacillus plantarum 80, a strain which lacks proton motive force-linked D-xylose transport activity. The role of the XylT protein was confirmed by the accumulation of D-xylose in L. plantarum 80 cells, and this accumulation was dependent on the proton motive force generated by either malolactic fermentation or by the metabolism of D-glucose. The apparent affinity constant of XylT for D-xylose was approximately 215 microM, and the maximal initial velocity of transport was 35 nmol/min per mg (dry weight). Furthermore, of a number of sugars tested, only 6-deoxy-D-glucose inhibited the transport of D-xylose by XylT competitively, with a Ki of 220 microM.
A simple field test for the assessment of physical fitness. (1963)

An essential factor in air safety is the physical and mental fitness of all personnel directly involved in operations of general, commercial, and military aviation. Standardization and classification of fitness, however, have not been established to a degree that would allow for much more than a differentiation between normal health and pathological disturbances. \n\nTesting a large population is important for the establishment of standards requires test procedures of simple design but capable of rendering results which a re comparable to those of more complex and time consuming laboratory tests. Experiments have indicated \nthat a 15-minute best-effort run can be utilized as a substitute for a standard work capacity test in the laboratory. This type of test constitutes a satisfactory assessment of the potentially available functional reserves. \n\n
An approach for constructing component-based software systems with dynamic adaptability using LEAD++ (2002)

A software system has dynamic adaptability if it can adapt itself to dynamically changing runtime environments. This means that such a software system can change its own behavior depending on states of runtime environments in flexible way. We have proposed a software model with dynamic adoptability named DAS and its description language LEAD++. The DAS model is a reflective software model, and LEAD++ is an object-oriented reflective language based on Java. In this work, we apply our model to component-based software systems, and introduce dynamic adaptability into them by using LEAD++. The basic approaches are to change dynamically: the structure of component composition; and the inside behavior of each component, depending on the states of runtime environments.
A Method for High Efficiency YAC Lipofection into Murine Embryonic Stem Cells (1996)

We describe a modified protocol for introducing yeast artificial chromosomes (YACs) into murine embryonic stem (ES) cells by lipofection. With a decreased DNA:cell ratio, increased concentration of condensing agents and altered culture conditions, this protocol reduces the requirement for YAC DNA to a few micrograms, improves the recovery of neomycin-resistant ES colonies and increases the yield of clones containing both flanking vector markers and insert. These modifications enable generation of sufficient 'intact' transgenic clones for biological analysis with a single experiment.
A Lower Audiometric Limit for Auditory Brainstem Response (ABR) (1982)

A lower audiometric frequency limit for reproducible ABR in response to 75 dB and 85 dB nHL 2.0 kHz haversine wave stimuli was defined by testing subjects with steep high-tone loss of varying cut-off frequencies. The limit between audiograms with and without reproducible ABR passed roughly through 40-50 dB HL at 500 Hz and 80-90 dB HL at 1000 Hz. Lack of ABR was not equivalent to lack of potentially useful hearing.
bldA dependence of undecylprodigiosin production in Streptomyces coelicolor A3(2) involves a pathway-specific regulatory cascade (1997)

The production of the red-pigmented tripyrrole antibiotic undecylprodigiosin (Red) by Streptomyces coelicolor A3(2) depends on two pathway-specific regulatory genes, redD and redZ. RedD is homologous to several other proteins that regulate antibiotic production in streptomycetes; RedZ is a member of the response regulator family. redZ transcripts were detected during exponential growth and increased in amount during transition and stationary phases; transcription of redD was confined to the two latter stages of growth. Whereas mutation of redD had no effect on redZ transcription, transcription of redD was highly dependent on redZ, suggesting that RedZ is a transcriptional activator of redD. bldA, which encodes the only tRNA of S. coelicolor that can efficiently translate the rare leucine codon UUA, is required for Red production at higher phosphate concentrations. While the redD transcript contains no UUA codons, the redZ mRNA contains one. Transcription of redZ appeared to be unaffected in a bldA mutant; in contrast, redD transcription was undetectable, consistent with the translational dependence of redZ on bldA and the transcriptional dependence of redD on redZ. Red production in a bldA mutant was restored by multiple copies of redZ, presumably reflecting a low level of mistranslation of the redZ UUA codon, while multiple copies of redD had no effect, presumably a consequence of the severe dependence of redD transcription on RedZ. Transcription of redZ appears to be negatively autoregulated.
Fundamentals of Crystallography (A survey of polymer crystallization by X-ray diffraction . chapter 1) (2006)

Insolids
Perfluoro-N-[4-(1H-tetrazol-5-ylmethyl)phenyl]alkanamides. A new class of oral antidiabetic agents (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPerfluoro-N-[4-(1H-tetrazol-5-ylmethyl)phenyl]alkanamides. A new class of oral antidiabetic agentsKenneth L. Kees, Robert S. Cheeseman, Dorothy H. Prozialeck, and Kurt E. SteinerCite this: J. Med. Chem. 1989, 32, 1, 11–13Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://doi.org/10.1021/jm00121a003RIGHTS & PERMISSIONSArticle Views302Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (360 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Cu(I)-Catalyzed Intramolecular Cyclization of Alkynoic Acids in Aqueous Media:  A “Click Side Reaction” (2007)

Alkynoic acids, in particular, 4-pentynoic acid derivatives, undergo intramolecular cyclizations to enol lactones under reaction conditions typically applied for the Cu(I)-catalyzed cycloaddition of terminal alkynes and azides (click chemistry). Starting from appropriate alkynoic acid derivatives, either enol lactones or 1,2,3-triazole click products can be obtained selectively by Cu(I) catalysis in aqueous media.
Fatigue. A New Test Method for Mode II Fatigue Crack Growth in Hard Materials. (2001)

Flaking type failure in rolling contact fatigue is usually attributed to the fatigue induced by cyclic subsurface shearing stress caused by contact loading. We suppose that this type of subsurface crack growth is essentially a mode II fatigue crack growth under the condition in which tensile mode growth is suppressed due to the compression stress field arising from the contact stress.Although the newly developed apparatus is, as the former apparatus, based on the principle that the static KI and the compressive stress parallel to the pre-crack are superimposed to mode II loading, we employ a new mechanism for mode II load application. In the new apparatus, a direct loading system is employed instead of the four-points-shear loading system used in the former apparatus. A new device for the application of compressive stress parallel to the pre-crack is also developed. Due to these alterations, mode II cyclic loading tests for hard steels have become possible at arbitrary stress ratios, including fully reversed loading (R=-1) which is the case of rolling contact fatigue.The tests were made on bearing steel SUJ2 and 0.75% carbon steel. The hardness of these two steels was around HRC60. The test results showed that stable mode II fatigue crack growth occurred in the region of ΔKII=3-10MPa√m, and that ΔKII-threshold values for mode II fatigue crack growth of these two steels were estimated to be around 3MPa√m. The apparent effect of load ratio was not observed in the data of R=0 and R=-1.