gebhart/patrepeval huggingface dataset:
Incremental Support Vector Machine Framework for Visual Sensor Networks (2006)

Motivated by the emerging requirements of surveillance networks, we present in this paper an incremental multiclassification support vector machine (SVM) technique as a new framework for action classification based on real-time multivideo collected by homogeneous sites. The technique is based on an adaptation of least square SVM (LS-SVM) formulation but extends beyond the static image-based learning of current SVM methodologies. In applying the technique, an initial supervised offline learning phase is followed by a visual behavior data acquisition and an online learning phase during which the cluster head performs an ensemble of model aggregations based on the sensor nodes inputs. The cluster head then selectively switches on designated sensor nodes for future incremental learning. Combining sensor data offers an improvement over single camera sensing especially when the latter has an occluded view of the target object. The optimization involved alleviates the burdens of power consumption and communication bandwidth requirements. The resulting misclassification error rate, the iterative error reduction rate of the proposed incremental learning, and the decision fusion technique prove its validity when applied to visual sensor networks. Furthermore, the enabled online learning allows an adaptive domain knowledge insertion and offers the advantage of reducing both the model training time and the information storage requirements of the overall system which makes it even more attractive for distributed sensor networks communication.
Efficient transient compression using an all-silicon nonlinear transmission line (1998)

Nonlinear transmission lines (NLTLs) have so far only been fabricated on GaAs. Here, an NLTL was monolithically integrated on a 2000-/spl Omega//spl middot/cm silicon substrate, demonstrating the applicability of the NLTL concept to silicon millimeter-wave integrated circuits (SIMMWICs). The fall time of 74 ps of a 4-GHz sinewave was compressed to 32 ps at the output of the NLTL, in accordance with theory. This is the first working NLTL on silicon to our knowledge.
Hierarchical test generation under architectural level functional constraints (1996)

In hierarchical test generation, the test vectors for the low level structure of the module under test are computed and then justified at a high level. In the module test computation procedure, a low level ATPG tool is conventionally applied to the complete structure of that particular module without adding extra information. Due to the architectural level functional constraints applied to the inputs of that module, many of the test vectors being computed are not justifiable at the high level. Therefore, high efficiency cannot be achieved without managing the functional constraint problem in the hierarchical ATPG process. In this paper, both top-down and bottom-up approaches are addressed. It is shown that the valid control code abstraction and test cube justification techniques are very effective to overcome the architectural level functional constraint problem and to achieve high efficiency in test computation. The proposed algorithms have been implemented in our hierarchical ATPG package and promising experimental results have been derived. We conclude that architectural level functional constraints can be efficiently avoided through these techniques.
Disjointed Multipath Routing for Real-Time Data in Wireless Multimedia Sensor Networks (2014)

Wireless multimedia sensor networks with sensing and processing abilities of multimedia data have recently emerged as one of the most important technologies for high quality monitoring. The routing scheme for multimedia data is an important research issue addressed in wireless multimedia sensor networks. In this paper, we propose a disjointed multipath routing scheme for real-time data transmission in wireless multimedia sensor networks. The proposed scheme uses a hybrid routing protocol based on Bluetooth and Zigbee in order to overcome the limitation of low bandwidth in conventional sensor networks. The proposed scheme also performs disjointed multipath routing based on competition to alleviate the delay of routing path setup. To show the superiority of our proposed scheme, we compare it with the existing scheme through performance evaluation. Our experimental results show that our proposed scheme reduces the end-to-end delay by about 30% and the routing path setup costs by about 22% over the existing scheme. Our scheme also increases data reception rates by about 690% over the existing scheme on average.
RNA editing of apolipoprotein B mRNA. Sequence specificity determined by in vitro coupled transcription editing. (1990)

Apolipoprotein (apo) B-48 mRNA is produced by in vivo RNA editing which involves a C----U conversion of the first base of the codon CAA for Gln-2153, changing it to UAA, an in-frame stop codon. We have reproduced the editing reaction in vitro using nuclear extracts. Efficient RNA editing was demonstrated by using apoB mRNA segments as substrate or in a coupled transcription-editing reaction using apoB minigenes as template. ApoB minigenes were constructed by ligating the adenovirus major late promoter to a fragment of apoB-100 DNA containing the editing site and used for the transcription-editing reaction. We defined the sequence specificity of the editing reaction using site-specific single and multiple base mutants constructed by the polymerase chain reaction. Among 22 different mutant apoB-100 minigene constructs containing mutations in the bases immediately flanking the edited C-6666, 20 were edited in the coupled transcription-editing reaction. The results suggest a relatively lax sequence specificity for apoB mRNA editing. Our observation may have important implications for apoB-48 biogenesis as well as for the editing process as a general biologic regulatory mechanism.
An adaptive scheme for compensation of loss of effectiveness of flight control effectors (2003)

In this paper we present two stable adaptive tracking control algorithms for compensation of loss of effectiveness of control effectors in flight control applications. The overall approach is based on suitable failure parameterization, control law and adaptive algorithm design, and Lyapunov analysis of the properties of the overall system. The proposed adaptive algorithms are based on parameter-adaptive and variable-structure control approaches. It is shown that, in both cases, the overall system is stable and the tracking error converges to zero asymptotically. The properties of the proposed algorithms are illustrated through simulations of the F/A-18C/D aircraft in the presence of multiple control effector failures. The proposed algorithms appear to be promising tools for effective on-line compensation of multiple flight critical failures.
Competency-based selection and assignment of human resources to construction projects (2011)

As part of human resource management policies and practices, construction firms need to define competency requirements for project staff, and recruit the necessary team for completion of project assignments. Traditionally, potential candidates are interviewed and the most qualified are selected. Precise computing models, which could take various candidate competencies into consideration and then pinpoint the most qualified person with a high degree of accuracy, would be beneficial. This paper presents a fuzzy adaptive decision making model for selection of different types of competent personnel. For this purpose, human resources are classified into four types of main personnel: Project Manager, Engineer, Technician, and Laborer. Then the competency criteria model of each main personnel is developed. Decision making is performed in two stages: a fuzzy Analytic Hierarchy Process (AHP) for evaluating the competency criteria, and an Adaptive Neuro-Fuzzy Inference System (ANFIS) for establishing competency IF-THEN rules of the fuzzy inference system. Finally, a hybrid learning algorithm is used to train the system. The proposed model integrates a fuzzy logic qualitative approach and neural network adaptive capabilities to evaluate and rank construction personnel based on their competency. Results from this system in personnel staffing show the high capability of the model in making a high quality personnel selection.
Regio‐ and Chemoselective Metalation of Arenes and Heteroarenes Using Hindered Metal Amide Bases (2011)

The preparation of highly functionalized organometallic compounds can be achieved by direct C-H activation of a broad range of unsaturated substrates using lithium chloride solubilized 2,2,6,6-tetramethylpiperidide bases (TMP(n)MX(m)⋅p LiCl). These are excellent reagents for converting a wide range of aromatic and heterocyclic substrates into valuable organometallic reagents with broad applications in organic synthesis.
Preparation of Substituted Methyl o-Nitrophenyl Sulfides (2002)

The nucleophilic substitution of substituted o-nitrochlorobenzenes with substituted methanethiolates, catalysed with triethylamine or pyridine, has been used to prepare a series of appropriately substituted methyl-o-nitrophenylsulfides. The prepared compounds were identified by their 1H- and 13C-NMR spectra. The base catalysed ring closure of methyl 2-(methoxycarbonylmethylsulfanyl)-3,5-dinitrobenzenecarboxylate only results in an attack of carbanion on the ester group, not on a nitro group as with the other compounds prepared. The cyclisation product is methyl 3-hydroxy-5,7-dinitrobenzo[b]thiophene-2-carboxylate (11).
Integrated-optic surface-plasmon-resonance biosensor using gold nanoparticles by bipolarization detection (2005)

A new integrated-optic surface-plasmon-resonance (SPR) biosensor using gold nanoparticles with the ability of bipolarization interrogation is demonstrated. Although the previous SPR biosensor using gold nanoparticles can excite the surface plasma wave by the TM- and the TE-polarized lightwave, the sensitivity to the environmental index change for the TE-polarized lightwave is too low to be useful. The new integrated-optic SPR biosensor with a ridge waveguide structure can produce the obvious SPR wavelength shifts varied with the analyte concentration for two orthogonal polarizations. Therefore, two kinds of analytes can be separately detected by the TM- and the TE- polarized modes in one SPR biosensor, and the number of detectable biomaterials by the biosensor array in one chip can be doubled. This SPR biosensor is designed for the concentration measurement of beta-blocker, which is a remedy for heart disease. In the linear operation range, the SPR wavelength increases with the concentration of beta-blocker at a rate of 0.073 and 0.029 nm/ppm for the TM- and the TE- polarized modes, respectively.
Improved Platelet Counting Using Two-Dimensional Laser Light Scatter (2000)

Clinical management of platelet disorders depends on accurate platelet counts. We evaluated a new analytic approach for platelet counting based on improved platelet discrimination. Current automated counting methods provide accurate platelet counts for most samples but often are unable to discriminate platelets accurately from nonplatelet particles such as microcytic RBCs, RBC fragments, and cellular debris that may falsely elevate platelet counts. The new approach measures 2 light-scatter angles of platelets and nonplatelet particles as they pass through a laser beam. The volume and refractive index of each platelet and particle are derived from the light-scatter measurements using the Mie scattering theory. Together, these 2 measurements provide improved platelet discrimination compared with 1-dimensional methods. With its improved discrimination, 2-dimensional platelet analysis provides more accurate platelet counts in samples containing interfering particles and may contribute to more effective clinical management of patients with platelet disorders.
Smart single-chip CMOS microhotplate array for metal-oxide-based gas sensors (2004)

A monolithic gas sensor system is presented, which includes on a single chip an array of three metal-oxide covered microhotplates, each of which is individually addressable and can be operated at a defined temperature. The monolithically co-integrated circuitry consists of three independent temperature control loops for the microhotplates and an on-chip temperature sensor. An innovative design of a circular-shape microhotplate has been realized. Temperature homogeneity and thermal efficiency of the membrane were optimized for use with thick films of nanocrystalline metal oxides as sensitive layers. A SnO/sub 2/-based sensing material with noble metal doping was operated at different temperatures as well as in temperature pulsing mode. Chemical sensor measurements have been conducted with, e.g., CO to show the system performance.
Gain of 1q21 Is an Unfavorable Genetic Prognostic Factor for Multiple Myeloma Patients Treated with High-Dose Chemotherapy (2009)

The prognostic significance of 1q21 gain, del(13)(q14), del(17)(p13), t(4;14)(p16.3;q32), and t(11;14)(q13;q32) detected by interphase fluorescein in situ hybridization (FISH) was studied in a cohort of 91 patients with newly diagnosed multiple myeloma (MM). 1q21 gain was detected in 37 of 91 patients (40.7%). In comparison with patients lacking 1q21 gain, patients with 1q21 gain had significantly shorter progression-free survival (PFS) (14.9 versus 27.4 months; P = .044) and worse 4-year overall survival (OS) (40.1% versus 76.2% of patients; P = <.001). PFS or OS were not influenced by the presence or absence of the other studied chromosomal abnormalities. Although the occurrence of 1q21 gain correlated with deletion of 13q14, the presence of 1q21 gain can be considered an independent prognostic factor, as no impact of del(13)(q14) as an isolated chromosomal abnormality on either PFS or OS has been observed. In comparison with patients lacking 1q21 gain, patients with 1q21 gain were significantly more likely to discontinue the preplanned treatment protocol because of disease progression or death. We conclude that 1q21 gain defines a prognostically unfavorable group of MM patients.
Sales Forecasting with Partial Recurrent Neural Networks: Empirical Insights and Benchmarking Results (2015)

Partial Recurrent Neural Networks (PRNN) belong to the family of Artificial Neural Networks. Due to their specific architecture, PRNN are well-suited to forecast time series data. Their ability to outperform well-known statistical forecasting models has been demonstrated in some application domains. However, the potential of PRNN in business decision support and sales forecasting in particular has received relatively little attention. The paper strives to close this research gap. In particular, the paper provides a managerial introduction to PRNN and assesses their forecasting performance vis-à-vis challenging statistical benchmarks using real-world sales data. The sales time series are selected such that they encompass several characteristic patterns (e.g., Seasonality, trend, etc.) and differ in shape and length. Such heterogeneity is commonly encountered in sales forecasting and facilitates a holistic assessment of PRNN, and their potential to generate operationally accurate forecasts.
Structural Effects of Framework Mutations on a Humanized Anti-Lysozyme Antibody (2001)

A humanized version of the mouse anti-lysozyme Ab D1.3 was previously constructed as an Fv fragment and its structure was crystallographically determined in the free form and in complex with lysozyme. Here we report five new crystal structures of single-amino acid substitution mutants of the humanized Fv fragment, four of which were determined as Fv-lysozyme complexes. The crystals were isomorphous with the parent forms, and were refined to free R values of 28-31% at resolutions of 2.7-2.9 A. Residue 27 in other Abs has been implicated in stabilizing the conformation of the first complementarity-determining region (CDR) of the H chain, residues 31-35. We find that a Phe-to-Ser mutation at 27 alters the conformation of immediately adjacent residues, but this change is only weakly transmitted to Ag binding residues in the nearby CDR. Residue 71 of the H chain has been proposed to control the relative disposition of H chain CDRs 1 and 2, based on the bulk of its side chain. However, in structures we determined with Val, Ala, or Arg substituted in place of Lys at position 71, no significant change in the conformation of CDRs 1 and 2 was observed.
New Colon Cancer Gene Discovered (1993)

A new gene has been discovered, by genetic linkage studies, that predisposes to colon cancer. The gene was discovered by linkage to a microsatellite marker on human chromosome 2. The microsatellite DNA shows a high degree of variation in colon cancers, varying in length from tumor to tumor. The gene may act by destabilizing the genome. Different groups looking at different satellite markers saw thousands of microsatellite instabilities throughout the genome, raising the possibility that the DNA as a whole is not being copied correctly, apparently due to a gene mutation that causes wholesale errors during DNA replication. Researchers hope to use the gene as a screening tool for screening individuals susceptible to colon cancer.
One-Time Biometric Token based Authentication (2014)

Widely used online commerce systems require an user to submit his sole banking credentials or credit card details for availing desired services, thus involving high risks with untrusted service providers. Often used one-time password based systems provide additional transaction security, but are still incapable of differentiating between a genuine user trying to authenticate or an adversary with stolen credentials. This brings out a strong need for biometrics based one-time password systems. In this paper we propose a one-time biometric token based authentication protocol which works within the framework of current online transaction schemes allowing an user to carry out a financial transaction with a service provider which completes with an authorization from the bank. The proposed protocol is based on key-binding biometric cryptosystems and upholds the requirements of secure authentication, template protection and revocability while providing privacy to individual's biometrics and anonymity from the service provider. We demonstrate our system's security and performance using iris biometrics to authenticate individuals.
Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease (2007)

Impaired bone formation contributes to the lack of bone healing in multiple myeloma and there is a need for agents with bone anabolic properties to reverse the bone deficit in patients. Bortezomib, a proteasome inhibitor with antitumour efficacy in myeloma patients, enhanced new bone formation in mouse calvarial cultures; this effect was blocked by dickkopf 1(Dkk1), an antagonist of Wnt signalling implicated in myeloma bone disease. Bortezomib inhibited Dkk1 expression in calvariae and bone marrow-derived stromal cells, suggesting a novel mechanism by which bortezomib exerts its effects in bone. Clinical trials in patients with myeloma bone disease are needed to validate these results.
Error Suppression for Hamiltonian-Based Quantum Computation Using Subsystem Codes (2017)

We present general conditions for quantum error suppression for Hamiltonian-based quantum computation using subsystem codes. This involves encoding the Hamiltonian performing the computation using an error detecting subsystem code and the addition of a penalty term that commutes with the encoded Hamiltonian. The scheme is general and includes the stabilizer formalism of both subspace and subsystem codes as special cases. We derive performance bounds and show that complete error suppression results in the large penalty limit. To illustrate the power of subsystem-based error suppression, we introduce fully two-local constructions for protection against local errors of the swap gate of adiabatic gate teleportation and the Ising chain in a transverse field.
Expression and function of mouse Fas antigen on immature and mature T cells. (1995)

We prepared mAbs specific for the mouse Fas Ag (CD95) and used them to analyze the expression and apoptosis-inducing activity of the Fas Ag on murine immunocytes. Cytofluorometry of mouse bone marrow, thymus, and splenocytes using the mAbs indicated that cells of the T lineage, except for bone marrow cells, expressed Fas Ag on the surface. CD4-CD8- undifferentiated thymocytes expressed low levels of Fas Ag. Immature CD4+CD8+ thymocytes and mature CD4+CD8- and CD4-CD8+ thymocytes were highly positive for Fas Ag. CD4+CD8+ thymocytes were specifically sensitive to the apoptosis-inducing activity of anti-Fas, although CD4-CD8-, CD4+CD8-, and CD4-CD8+ thymocytes were resistant. Spleen T cells were resistant to anti-Fas, whereas they expressed Fas Ag. The superantigen, staphylococcal enterotoxin B (SEB) administered to BALB/c mice, induced clonal expansion and successive clonal deletion of spleen T cells bearing the V beta 8 TCR, which specifically reacts to SEB. Such clonal deletion of V beta 8 T cells was highly suppressed in lpr mice, which have defects in the Fas Ag gene. In SEB-administrated BALB/c mice, expression of Fas Ag was significantly enhanced on V beta 8, but not on V beta 6 T cells, which cannot react to SEB. Moreover, V beta 8 T cells in SEB-primed mice were sensitive to the cell-killing activity of anti-Fas, although V beta 6 T cells were resistant. These findings show that the expression level and apoptosis-inducing activity of Fas Ag on peripheral T cells are directly up-regulated by stimulation through the TCR in vivo.
Wound Regeneration and Repair (2013)

In Wound Regeneration and Repair: Methods and Protocols, expert researchers in the field detail classical and cutting-edge methods for studying wound healing and regeneration. These techniques include
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer (2015)

Genome-wide association studies (GWAS) of colorectal cancer (CRC) have identified 23 susceptibility loci thus far. Analyses of previously conducted GWAS indicate additional risk loci are yet to be discovered. To identify novel CRC susceptibility loci, we conducted a new GWAS and performed a meta-analysis with five published GWAS (totalling 7,577 cases and 9,979 controls of European ancestry), imputing genotypes utilising the 1000 Genomes Project. The combined analysis identified new, significant associations with CRC at 1p36.2 marked by rs72647484 (minor allele frequency [MAF] = 0.09) near CDC42 and WNT4 (P = 1.21 × 10(-8), odds ratio [OR] = 1.21 ) and at 16q24.1 marked by rs16941835 (MAF = 0.21, P = 5.06 × 10(-8); OR = 1.15) within the long non-coding RNA (lncRNA) RP11-58A18.1 and ~500 kb from the nearest coding gene FOXL1. Additionally we identified a promising association at 10p13 with rs10904849 intronic to CUBN (MAF = 0.32, P = 7.01 × 10(-8); OR = 1.14). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CRC. Additionally, our analysis further demonstrates that imputation can be used to exploit GWAS data to identify novel disease-causing variants.
StegExpose - A Tool for Detecting LSB Steganography (2014)

Steganalysis tools play an important part in saving time and providing new angles of attack for forensic analysts. StegExpose is a solution designed for use in the real world, and is able to analyse images for LSB steganography in bulk using proven attacks in a time efficient manner. When steganalytic methods are combined intelligently, they are able generate even more accurate results. This is the prime focus of StegExpose.