gebhart/patrepeval huggingface dataset:
Suppression of Rev3, the catalytic subunit of Polζ, sensitizes drug-resistant lung tumors to chemotherapy (2010)

Platinum-based chemotherapeutic drugs are front-line therapies for the treatment of non-small cell lung cancer. However, intrinsic drug resistance limits the clinical efficacy of these agents. Recent evidence suggests that loss of the translesion polymerase, Polζ, can sensitize tumor cell lines to cisplatin, although the relevance of these findings to the treatment of chemoresistant tumors in vivo has remained unclear. Here, we describe a tumor transplantation approach that enables the rapid introduction of defined genetic lesions into a preclinical model of lung adenocarcinoma. Using this approach, we examined the effect of impaired translesion DNA synthesis on cisplatin response in aggressive late-stage lung cancers. In the presence of reduced levels of Rev3, an essential component of Polζ, tumors exhibited pronounced sensitivity to cisplatin, leading to a significant extension in overall survival of treated recipient mice. Additionally, treated Rev3-deficient cells exhibited reduced cisplatin-induced mutation, a process that has been implicated in the induction of secondary malignancies following chemotherapy. Taken together, our data illustrate the potential of Rev3 inhibition as an adjuvant therapy for the treatment of chemoresistant malignancies, and highlight the utility of rapid transplantation methodologies for evaluating mechanisms of chemotherapeutic resistance in preclinical settings.
Investigating an outbreak of staphylococcal food poisoning among travellers across two Australian states (2015)

Food poisoning due to toxin-mediated S. aureus is frequently undetected and underreported. Public health units should consider toxin-producing pathogens such as S. aureus when investigating outbreaks where vomiting is the predominant symptom and occurs rapidly after consuming food.
The biology and serology of Epstein-Barr virus (EBV) infections. (1977)

The Epstein-Barr virus (EBV), carried by the majority of the world's adult human population, is closely associated with three known human diseases; infectious mononucleosis IM), Burkitts lymphoma (BL) and nasopharyngeal carcinoma (NPC). It is now generally accepted that EBV plays an active role in the etiology of BL and NPC rather than simply being a "passenger". Considerable evidence also argues for the participation of "co-factors" in these two diseases. Environmental co-factors appear needed to explain the peculiar geographical distribution of BL. Among various possibilities that must be considered are insect-transmitted agents that could lead to eventual immunosuppression and/or stimulate further proliferation of EBV-transformed cells, thereby permitting an additional cytogenetic evolution towards malignancy. Recent studies have uncovered a possible cytogenetic co-factor in the ethiology of BL; the 8-14 chromosomal translocation. Genetic co-factors, on the other hand, are likely to be involved in the etiology of NCP. EBV is a B-cell associated virus. Carrier lymphoid cell lines obtained either by in vitro "immortalization" of human cord-blood lymphocytes or by explants from IM and African BL donors harbor multiple copies of the EBV genome, and viral genetic sequences have also been directly detected in biopsies of African BL. The state of the viral genomes in the carrier cell appears to be such that some are integrated into the cellular DNA while others exist as free, covalently closed circular molecules.
Efficient 3D wavelet transform decomposition for video compression (2002)

We present an efficient three-dimensional wavelet transform (3D-WT) algorithm for video compression. This algorithm performs the temporal decomposition of a video sequence in a more efficient way than the classical 3D-WT algorithm. We have conducted a set of experimental evaluations of the proposed algorithm using various video sequences. Experimental results show that our algorithm exhibits lower memory demands and lower latencies for the compression and decompression processes than the classical algorithm at the same compression ratio.
Novel solid protein solder designs for laser-assisted tissue repair (2000)

The novel solid protein solder designs presented here add a new dimension to tissue repair as their flexible, moldable, and absorption controllable nature, greatly improves the clinical applicability of laser-assisted tissue repair.
Multi-inverter UPS system with redundant load sharing control (1990)

The concept of a redundant multi-inverter UPS (uninterruptible power supply) system which includes extended monitoring of the status and the operating conditions of all power electronic equipment is described. Each block of the UPS system is monitored by two independent microcomputers that process the same data. The microcomputers are part of a redundant distributed monitoring system that is separately interlinked by two serial data buses through which they communicate. They establish a hierarchy among the participating blocks by defining one of the healthy inverter blocks as the master. The actual master runs the central synchronizing unit for the entire system, whereas the slave units perform the control of equal active and reactive load sharing. Operation and fault detection are experimentally illustrated in a dual inverter system with a rating of 10 kVA of redundant power.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis of triethoxysilyl-terminated polyoxazolines and their cohydrolysis polymerization with tetraethoxysilane (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of triethoxysilyl-terminated polyoxazolines and their cohydrolysis polymerization with tetraethoxysilaneYoshiki Chujo, Eiji Ihara, Shigeo Kure, and Takeo SaegusaCite this: Macromolecules 1993, 26, 21, 5681–5686Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/ma00073a023https://doi.org/10.1021/ma00073a023research-articleACS PublicationsRequest reuse permissionsArticle Views786Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Relationship of Enteric Microbial Infection and Functional Bowel Disorders (2007)

Acute bacterial gastroenteritis is the strongest risk factor identified to date for the subsequent development of postinfective irritable bowel syndrome. Clinical risk factors include prolonged acute illness and the absence of vomiting. A genetically determined susceptibility to inflammatory stimuli may also be a risk factor for irritable bowel syndrome. The underlying pathophysiology indicates increased intestinal permeability and low-grade inflammation, as well as altered motility and visceral sensitivity. The prognosis is similar to that of other forms of irritable bowel syndrome with over 50% of patients but the long-term complications are poorly understood.
Electron Beam Curing of Elastomers (2006)

Abstract Modification of thermoplastic and rubbery materials by electron beam (EB) radiation is a potential method for development of new polymers and composites. Irradiation of polymeric materials results in grafting and subsequently formation of a three dimensional network through the union of generated macro radicals. In the Green drive, i.e. to make the world pollution free, this technology takes an important position. Curing of a number of both non-polar and polar elastomers using an electron beam was carried out in our laboratory. The effects of irradiation dose in presence and absence of radiation sensitizer on the crosslinking and structure of ethylene propylene rubber, ethylene octene copolymer, nitrile, acrylic and fluorocarbon rubbers were investigated. An analysis of crosslink to scission ratio on the basis of Charlesby-Pinner Equation was done. Mechanical and dynamic mechanical properties showed that these improved with radiation dose and sensitizer level up to certain values, beyond which the properties deteriorated due to chain scission reactions. The properties of the vulcanizates were correlated with the structure. EB cured samples were compared with the samples having conventional crosslinks. Some applications of the electron beam curing are highlighted.
Zur Kenntnis der Organophosphorverbindungen, XIX. Synthese und Eigenschaften bifunktioneller Organobromphosphane (1982)

Abstract Bifunktionelle Organobromphosphane Br 2 P[CH 2 ] n PBr 2 (n = 1–10) 1 und BrP(R′)RP‐(R′)Br (R = [CH 2 ] n , p ‐C 6 H 4 ; R′ = Alkyl, Ph) 4 bzw. 8a wurden in Abhängigkeit von n, R und R′ nach verschiedenen Verfahren synthetisiert. Einige ihrer Reaktionen werden beschrieben und ihre 31 P‐NMR‐Spektren diskutiert. 1,2‐Diphosphacycloalkane 13 wurden in stereospezifischer Reaktion durch Dehalogenierung von 4 mit Metallen erhalten.
Process for Production and Purification of Carboxy Telechelic Polymers (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProcess for Production and Purification of Carboxy Telechelic PolymersC. A. Wentz and E. E. HopperCite this: Ind. Eng. Chem. Prod. Res. Dev. 1967, 6, 4, 209–211Publication Date (Print):December 1, 1967Publication History Published online1 May 2002Published inissue 1 December 1967https://pubs.acs.org/doi/10.1021/i360024a003https://doi.org/10.1021/i360024a003research-articleACS PublicationsRequest reuse permissionsArticle Views42Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
System level design of radio frequency receiver for IEEE 802.16 standard (2008)

This paper presents a system level design of radio frequency receiver supporting WiMAX mobile standard. Based on direct conversion receiver, the distribution of the total radio system specifications to the individual receiver components is discussed. System level design techniques and theoretical calculation are developed. Simulation results and system simulation level are introduced for noise figure (NF), gain and linearity (third order intercept point, IIP3). Specifications obtained from the received budget can indicate that the noise and the linearity depend on the gain performance of the corresponding circuit blocks. The receiver achieves a total gain of 23 dB and an IIP3 of -7.8 dBm for low gain mode. It provides up to 68 dB gain, 6.5 dB noise figure and -16 dBm IIP3 for high gain mode.
Combining Fluorescent Probes and Biofunctional Magnetic Nanoparticles for Rapid Detection of Bacteria in Human Blood (2006)

Detection of bacteria in human blood within two hours is achieved through the use of vancomycin-functionalized FePt nanoparticles in combination with a vancomycin-conjugated fluorescent probe, as shown in the figure (B: bacteria; Van: vancomycin; FLA: fluorescein amine). This promises to be a sensitive and rapid protocol for detecting bacteria in blood products or other targets in biological samples.
Deacetylation of p53 induces autophagy by suppressing Bmf expression (2013)

Interferon γ (IFN-γ)-induced cell death is mediated by the BH3-only domain protein, Bik, in a p53-independent manner. However, the effect of IFN-γ on p53 and how this affects autophagy have not been reported. The present study demonstrates that IFN-γ down-regulated expression of the BH3 domain-only protein, Bmf, in human and mouse airway epithelial cells in a p53-dependent manner. p53 also suppressed Bmf expression in response to other cell death-stimulating agents, including ultraviolet radiation and histone deacetylase inhibitors. IFN-γ did not affect Bmf messenger RNA half-life but increased nuclear p53 levels and the interaction of p53 with the Bmf promoter. IFN-γ-induced interaction of HDAC1 and p53 resulted in the deacetylation of p53 and suppression of Bmf expression independent of p53's proline-rich domain. Suppression of Bmf facilitated IFN-γ-induced autophagy by reducing the interaction of Beclin-1 and Bcl-2. Furthermore, autophagy was prominent in cultured bmf(-/-) but not in bmf(+/+) cells. Collectively, these observations show that deacetylation of p53 suppresses Bmf expression and facilitates autophagy.
Role of Calcium Cycling Versus Restitution in the Mechanism of Repolarization Alternans (2004)

T-wave alternans, a powerful marker of arrhythmic events, results from alternation in action potential duration (APD). The underlying cellular mechanism of APD alternans is unknown but has been attributed to either intracellular calcium (Ca2+) cycling or membrane ionic currents, manifested by a steep slope of cellular APD restitution. To address these mechanisms, high-resolution optical mapping techniques were used to measure action potentials and Ca2+ transients simultaneously from hundreds of epicardial sites in the guinea pig model of pacing-induced T-wave alternans (n=7). The pacing rates (ie, alternans threshold) at which T-wave (369+/-11 bpm), APD (369+/-21 bpm), and Ca2+ (371+/-29 bpm) alternans first appeared were comparable. Importantly, the site of origin of APD alternans and Ca2+ alternans consistently occurred together near the base of the left ventricle, not where APD restitution was steepest. In addition, APD and Ca2+ alternans were remarkably similar both spatially and temporally during discordant alternans. In conclusion, the mechanism underlying T-wave alternans in the intact heart is more closely associated with intracellular Ca2+ cycling rather than APD restitution.
Beyond Question Answering: Understanding the Information Need of the User (2011)

Intelligent interaction between humans and computers has been a dream of artificial intelligence since the beginning of digital era and one of the original motivations behind the creation of artificial intelligence. A key step towards the achievement of such an ambitious goal is to enable the Question Answering systems understand the information need of the user.\nIn this thesis, we attempt to enable the QA system's ability to understand the user's information need by three approaches. First, an clarification question generation method is proposed to help the user clarify the information need and bridge information need gap between QA system and the user. Next, a translation based model is obtained from the large archives of Community Question Answering data, to model the information need behind a question and boost the performance of question recommendation. Finally, a fine-grained classification framework is proposed to enable the systems to recommend answered questions based on information need satisfaction.
Fractal dynamics of body motion in post-stroke hemiplegic patients during walking (2004)

In this paper, we quantify the complexity of body motion during walking in post-stroke hemiplegic patients. The body motion of patients and healthy elderly subjects was measured by using the accelerometry technique. The complexity of body motion was quantified using the maximum likelihood estimator (MLE-) based fractal analysis methods. Our results suggest that the fractal dimensions of the body motion in post-stroke hemiplegic patients at several Brunnstrom stages were significantly higher than those of healthy elderly subjects (p < 0.05). However, in the hemiplegic patients, the fractal dimensions were more related to Brunnstrom stages.
Biomimetic Hydrogel‐Based Actuating Systems (2013)

Abstract Active motion is intrinsic to all kinds of living organisms from unicellular ones to humans and inspires development of synthetic actively moving materials. Hydrogels, which are three dimensional polymer networks imbibed with aqueous solutions, mimic the swelling/shrinking behavior of plant cells and produce macroscopic actuation upon swelling and shrinking. This Feature Article covers basic principles of design as well as recent advances in the development of hydrogel based actuating systems. It is discussed how simply swelling can be used to generate very complex multistep motion, which can be used to develop new optical devices, sensors, biomaterials, smart surface, etc.
Photoacoustic tomography using a Mach-Zehnder interferometer as an acoustic line detector (2007)

A three-dimensional photoacoustic imaging method is presented that uses a Mach-Zehnder interferometer for measurement of acoustic waves generated in an object by irradiation with short laser pulses. The signals acquired with the interferometer correspond to line integrals over the acoustic wave field. An algorithm for reconstruction of a three-dimensional image from such signals measured at multiple positions around the object is shown that is a combination of a frequency-domain technique and the inverse Radon transform. From images of a small source scanning across the interferometer beam it is estimated that the spatial resolution of the imaging system is in the range of 100 to about 300 mum, depending on the interferometer beam width and the size of the aperture formed by the scan length divided by the source-detector distance. By taking an image of a phantom it could be shown that the imaging system in its present configuration is capable of producing three-dimensional images of objects with an overall size in the range of several millimeters to centimeters. Strategies are proposed how the technique can be scaled for imaging of smaller objects with higher resolution.
EM-based recursive estimation of channel parameters (1999)

Recursive (online) expectation-maximization (EM) algorithm along with stochastic approximation is employed in this paper to estimate unknown time-invariant/variant parameters. The impulse response of a linear system (channel) is modeled as an unknown deterministic vector/process and as a Gaussian vector/process with unknown stochastic characteristics. Using these models which are embedded in white or colored Gaussian noise, different types of recursive least squares (RLS), Kalman filtering and smoothing and combined RLS and Kalman-type algorithms are derived directly from the recursive EM algorithm. The estimation of unknown parameters also generates new recursive algorithms for situations, such as additive colored noise modeled by an autoregressive process. The recursive EM algorithm is shown as a powerful tool which unifies the derivations of many adaptive estimation methods.
Homogeneous dispersion of nanostructured aluminum nitride in a polyimide matrix (1994)

Advanced polymer/nanoparticle composites are currently of great interest because of their unique properties. The bulk properties of these materials are strongly influenced by the nature of the ultrafine filler particles–including their dispersion. A technique is presented for the de‐agglomeration of chemically synthesized aluminum nitride nanoparticles and their uniforn dispersion in a polymer matrix. Detrailed mechanisms for the de‐agglomeration are discussed as topics for future investigation.
Integrated Optic Diode Laser Stabilizer (1989)

A GaAlAs - CSP laser diode has been stabilized to a waveguide ring resonator. Frequency control to three parts in 10<sup>13</sup> peak-to-peak has been achieved. The simultaneous locking of two such lasers to one resonator has also been demonstrated. The compact laser/resonator module can withstand 60 g RMS vibration over a 2 kHz range and a peak shock level up to at least 3000 g.
Genetic and antigenic diversity of human rotaviruses: potential impact on the success of candidate vaccines (1999)

Licensing of the first human rotavirus vaccine raises the hope of a reduction in the burden of paediatric diarrheal disease. However, the less than optimal performance of this vaccine in trials carried out in developing countries indicates that improvements in vaccine design are necessary. Analysis of the genetic and antigenic diversity of rotavirus isolates collected from various geographical locations suggests that future vaccine formulations may need to include a broader spectrum of strains. This may increase vaccine efficacy by providing comprehensive coverage against circulating viruses. Continued surveillance and genetic analysis of the rotavirus population prior to and after the introduction of routine vaccination will reveal if the diversity of this pathogen will impact on the success of vaccine programs.
How Our Current Medical Care System Fails People With Diabetes (2009)

Many randomized controlled intervention trials have demonstrated that lowering glycemia (1,2), LDL cholesterol (3), and blood pressure (4) will markedly benefit the complications from diabetes. Based on these data, the American Diabetes Association has recommended the following targets for glycemic, lipid, and blood pressure outcome measures, A1C <7.0%, LDL cholesterol <100 mg/dl, and blood pressure <130/80 mmHg, respectively (5).

Most diabetic patients do not meet these recommended goals. Approximately half of the National Health and Nutrition Examination Survey cohort met the glycemic goal (6). In other larger reported populations, 21–43% of patients had A1C levels >9.5%, only 22–46% of diabetic patients met the LDL cholesterol goal, and 29–33% met the blood pressure goal (7). Far fewer, 2–10%, met the combined American Diabetes Association goals for glycemia, lipids, and blood pressure (7).

Many approaches have been tried to improve diabetes care but, with one exception, have been mostly ineffective. These include simply reminding patients about appointments; providing laboratory information on the patient to the physician, even when specific treatment recommendations for the individual patient were included; case management when the case manager could not make independent treatment decisions; education of physicians; and multifaceted quality improvement interventions in the practice setting (7).

The small amount of time a physician has to spend with a patient is an important limiting factor. This was amply illustrated in a study (8) in which eight process measures agreed upon by the physician group and whether the patient was due to receive them were displayed on the physicians’ computer screens at the time of the patient visit. The measures due were performed or ordered only one-third of the time. Physicians pinpointed lack of time and other problems that needed attention as primary obstacles to carrying out the agreed-upon recommendations.

The one approach …
The quarks of object-oriented development (2006)

A two-construct taxonomy is used to define the essential elements of object orientation through analysis of existing literature.