gebhart/patrepeval huggingface dataset:
Hypoxic Sensitizers — Implications for Radiation Therapy (1979)

THE proliferative capacity of human cells can be destroyed by ionizing radiation, and the rate of killing by radiation is 2.5 to three times higher in the presence of oxygen than under hypoxic conditions. Since solid tumors often have zones of necrosis and consequently are likely to contain hypoxic yet viable cells, this radiobiologic effect may have implications for cancer therapy. Radioresistant tumor cells that survive treatment can become reoxygenated and lead to a recurrence of the disease.A recent analysis of 2803 patients with carcinoma of the cervix treated with radiation therapy indicated that those with hemoglobin levels of . . .
'Without a Song You Are Nothing': Songwriters' Perspectives on Indigenising Tertiary Music and Sound Curriculum (2005)

‘W in indigenous spirituality. Mackinlay, a non-indigenous academic, recognises the importance that song plays in traditional Aboriginal custom and tradition. Speaking for and about country and spirituality for country are inherited and lcarncd components of Aboriginal identity and relationships LO land and kin, story and song. As a songwriter, this triggered a wave of personal philosophical and phenomenological thought. The implications of this in relation to my understanding of the relationships between sound and society and the power of song to communicate, store and reference important cultural knowledge was profound. At Queensland Univcrsity of Technology (QUT) where I work as an academic doing research and teaching music and music education, part of my role has been to ‘indigenise’ the music and sound curriculum. My colleague Jim Chapman has spent many years teaching and studying crosscultural musicianship in Australia, Africa and South America and is primarily a songwriter. In this article we provide two songwriters’ perspectives, which appear in case study vignette form. These vignettes are personal journeys of understanding that have led us both to develop dynamic indigenous per. spectives. We examine the processes and outcomes of ‘indigenising’ a tertiary music and sound curriculum and notions of Australian indigenous knowledge. We explore points of intersection and understanding and divergence and the role of music and sound as knowledge. This article combines these perspectives and proposes ‘rules of thumb’ for developing culturally inclusive tertiary music and sound curriculum.
Changes of chemical nature of photoresists induced by various plasma treatments and their impact on LWR (2006)

Changes in chemical nature of an ArF photoresist caused by various plasmas were analyzed, and it was found that the HBr plasma treatment induces a selective detachment of a heterocyclic unit of the photoresist, and the detached unit remains in the photoresist film. Thermomechanical analyses were performed, which showed that the softening temperature of the photoresist decreases by the HBr treatment, indicating that the detached heterocyclic unit acts as a plasticizer in the photoresist film. These results showed that the HBr treatment can be regarded as a softening process of the photoresist. This HBr treatment was applied to the fabrication of line patterns and it was shown that the treatment remarkably improves LWR (line width roughness) after etching. This improvement was more pronounced for the case of an isolated pattern than the case of a dense pattern. Further investigations on the HBr treatment were performed by changing the copolymerization ratio of a monomer containing the heterocyclic unit. It was shown that the reduction of LWR by the HBr treatment becomes more enhanced when the copolymerization ratio increases. However, an intensive HBr treatment was found to deteriorate LWR, showing that there is an optimum condition of the HBr treatment in terms of improving LWR.
Extending the Utility of Silicone Lubricants through Structural Modifications. (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleExtending the Utility of Silicone Lubricants through Structural Modifications.H. M. Schiefer, R. W. Awe, and C. L. WhippleCite this: J. Chem. Eng. Data 1961, 6, 1, 155–160Publication Date (Print):January 1, 1961Publication History Published online1 May 2002Published inissue 1 January 1961https://pubs.acs.org/doi/10.1021/je60009a031https://doi.org/10.1021/je60009a031research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Down-regulation of DNA replication in extracts of camptothecin-treated cells: activation of an S-phase checkpoint? (1997)

Extracts prepared from camptothecin (CPT)-treated cells have a reduced ability to support SV40 DNA replication in vitro. This reduction derives mainly from a reduction in the frequency of initiation events because DNA chain elongation remains practically unchanged. Mixing of extract from nontreated cells with small amounts of extract of CPT-treated cells indicates that the reduction in DNA replication is due to the synthesis/activation of a dominant inhibitor. The observed reduction in DNA replication activity cannot be attributed to inactivation of Topo I, the molecular target of camptothecin, because levels and activity of this protein remain unchanged in extracts of CPT-treated cells and addition of purified Topo I does not restore replication activity. Although replication protein A (RP-A) is phosphorylated in CPT-treated cells, reduced replication may not be caused by RP-A inactivation, because neither loss of phosphorylation nor the addition of recombinant RP-A restore replication activity. We interpret these observations as biochemical evidence for the activation of a checkpoint in S phase and discuss the ramifications of this activation on the mechanism of CPT-induced cytotoxicity.
DeepLung: Deep 3D Dual Path Nets for Automated Pulmonary Nodule Detection and Classification (2018)

In this work, we present a fully automated lung computed tomography (CT) cancer diagnosis system, DeepLung. DeepLung consists of two components, nodule detection (identifying the locations of candidate nodules) and classification (classifying candidate nodules into benign or malignant). Considering the 3D nature of lung CT data and the compactness of dual path networks (DPN), two deep 3D DPN are designed for nodule detection and classification respectively. Specifically, a 3D Faster Regions with Convolutional Neural Net (R-CNN) is designed for nodule detection with 3D dual path blocks and a U-net-like encoder-decoder structure to effectively learn nodule features. For nodule classification, gradient boosting machine (GBM) with 3D dual path network features is proposed. The nodule classification subnetwork was validated on a public dataset from LIDC-IDRI, on which it achieved better performance than state-of-the-art approaches and surpassed the performance of experienced doctors based on image modality. Within the DeepLung system, candidate nodules are detected first by the nodule detection subnetwork, and nodule diagnosis is conducted by the classification subnetwork. Extensive experimental results demonstrate that DeepLung has performance comparable to experienced doctors both for the nodule-level and patient-level diagnosis on the LIDC-IDRI dataset.\footnote{https://github.com/uci-cbcl/DeepLung.git}
Interferon-gamma attenuates hemorrhage-induced suppression of macrophage and splenocyte functions and decreases susceptibility to sepsis. (1992)

Although it is known that interferon-gamma synthesis and macrophage functions are depressed after hemorrhage, it remains to be determined whether systemic administration of interferon-gamma has any effect on hemorrhage-induced depression of macrophage and splenocyte functions. To study this, C3H/HEN mice were bled to a mean blood pressure of 35 mm Hg, maintained for 60 minutes, and followed by adequate fluid resuscitation. The mice then received either 1000 units interferon-gamma or saline solution (vehicle). Peritoneal (pM phi) and splenic (sM phi) macrophages and splenocytes were isolated 24 hours later. PM phi antigen presentation was measured by coculturing pM phi with the D10.G4.1 cell clone. Major histocompatibility complex class II (Ia) antigen expression was determined by direct immunofluorescence. Cytokine release by pM phi, sM phi, and splenocytes was assessed with specific bioassays. For survival studies, mice were subjected to sepsis 3 days after hemorrhage. Treatment with interferon-gamma restored (p less than or equal to 0.05) hemorrhage-induced suppression of pM phi antigen presentation capacity and Ia antigen expression and increased (p less than or equal to 0.05) interleukin-1 and tumor necrosis factor release by pM phi and sM phi, as well as splenocyte proliferation (p less than or equal to 0.05). Interferon-gamma also decreased (p less than or equal to 0.007) the susceptibility to sepsis after hemorrhage. Thus interferon-gamma represents a potent agent for treating hemorrhagic shock-induced immunosuppression and for increasing the ability of the host defense system to combat bacterial infections after hemorrhage.
Motion-Depth: RGB-D Depth Map Enhancement with Motion and Depth in Complement (2014)

Low-cost RGB-D imaging system such as Kinect is widely utilized for dense 3D reconstruction. However, RGB-D system generally suffers from two main problems. The spatial resolution of the depth image is low. The depth image often contains numerous holes where no depth measurements are available. This can be due to bad infra-red reflectance properties of some objects in the scene. Since the spatial resolution of the color image is generally higher than that of the depth image, this paper introduces a new method to enhance the depth images captured by a moving RGB-D system using the depth cues from the induced optical flow. We not only fill the holes in the raw depth images, but also recover fine details of the imaged scene. We address the problem of depth image enhancement by minimizing an energy functional. In order to reduce the computational complexity, we have treated the textured and homogeneous regions in the color images differently. Experimental results on several RGB-D sequences are provided to show the effectiveness of the proposed method.
A Method of Fast and Robust for Traffic Sign Recognition (2009)

This paper proposes a fast and robust algorithm for traffic sign detection and recognition. The algorithm includes two stages: traffic sign detection and recognition. In the first stage, Adaboost algorithm based red pixels model of speed limit sign in the Lab color space is built. Then the model is used to extract area of latent speed limit signs. After that, the improved Hough Transform is used to locate the signs precisely. In the second stage, the template matching algorithm is used to recognize the traffic sign. At the same time, a new method of rejecting non-signs is presented, which improved the recognition rate in the complex outdoor scenes.
A receiver-initiated collision-avoidance protocol for multi-channel networks (2002)

The medium-access control (MAC) protocols for wireless networks proposed or implemented to date based on collision-avoidance handshakes between sender and receiver either require carrier sensing or the assignment of unique codes to nodes to ensure that intended receivers hear data packets without interference from hidden sources. We present and analyze a new collision-avoidance MAC protocol that we call receiver-initiated channel-hopping with dual polling (RICH-DP). RICH-DP is the first MAC protocol based on a receiver-initiated collision-avoidance handshake that does not require carrier sensing or the assignment of unique codes to nodes In order to ensure collision-free reception of data at the intended receivers in the presence of hidden terminals. The throughput and delay characteristics of RICH-DP is studied analytically, and extensive simulations are presented to verify the analysis and to present a more accurate prediction of how RICH-DP would operate in realistic scenarios. RICH-DP is applicable to ad-hoc networks based on commercial off-the-shelf frequency hopping radios operating in the unlicensed frequency bands.
Design of a K-band transmit phased array for low Earth orbit satellite communications (2002)

The design of a lightweight, low cost phased array antenna is presented. Multilayer printed wiring board (PWB) technology is utilized for RF and DC/logic manifold distribution. Transmit modules are soldered on one side and patch antenna elements are on the other, allowing the use of automated assembly processes. The 19 GHz antenna has two independently steerable beams, each capable of transferring data at 622 Mbit/s. A passive, self-contained phase change thermal management system is also presented.
EPDL: Supporting Context-Based Energy Control Policy Design in IoT-Enabled Smart Buildings: Programing the Physical World with EPDL (2015)

Improving energy efficiency of buildings is an important step towards a more sustainable lifestyle. In the era of Internet of Things (IoT), interconnected smart devices change the application-programming paradigm of buildings. Smart building system and people cloud work in a more collaborative way for improving the energy efficiency. Obtaining fine-grained environmental information and controlling networked remote device are enabled through open web-based services. Writing flexible rules, which can utilize available services to control electricity appliances to act properly based on the acquired context for energy efficiency becomes possible. However, the complexity of a building makes it very complicated for non-expert users write energy control policy without studying the target building in detail. Hence, we proposed a user-friendly energy policy description language, called EPDL and implement a set of components to support the user in writing energy control policy easily for smart buildings. We discussed the readability and writability of EPDL, and showed it is an efficient tool for a non-expert user to write energy control policies for smart buildings.
Extraordinary Photocurrent Harvesting at Type-II Heterojunction Interfaces: Toward High Detectivity Carbon Nanotube Infrared Detectors (2012)

Despite the potentials and the efforts put in the development of uncooled carbon nanotube infrared detectors during the past two decades, their figure-of-merit detectivity remains orders of magnitude lower than that of conventional semiconductor counterparts due to the lack of efficient exciton dissociation schemes. In this paper, we report an extraordinary photocurrent harvesting configuration at a semiconducting single-walled carbon nanotube (s-SWCNT)/polymer type-II heterojunction interface, which provides highly efficient exciton dissociation through the intrinsic energy offset by designing the s-SWCNT/polymer interface band alignment. This results in significantly enhanced near-infrared detectivity of 2.3 × 10(8) cm·Hz(1/2)/W, comparable to that of the many conventional uncooled infrared detectors. With further optimization, the s-SWCNT/polymer nanohybrid uncooled infrared detectors could be highly competitive for practical applications.
Analysis, Design, Modeling, and Control of an Interleaved-Boost Full-Bridge Three-Port Converter for Hybrid Renewable Energy Systems (2016)

This paper presents the design, modeling, and control of an isolated dc-dc three-port converter (TPC) based on an interleaved-boost full-bridge converter with pulsewidth modulation (PWM) and phase-shift control for hybrid renewable energy systems. In the proposed topology, the switches are driven by phase-shifted PWM signals, where both phase angle and duty cycle are the controlled variables. The power flow between the two inputs is controlled through the duty cycle, whereas the output voltage can be regulated effectively through the phase shift. The primary-side MOSFETs can achieve zero-voltage-switching (ZVS) operation without additional circuitry. Additionally, due to the ac output inductor, the secondary-side diodes can operate under zero-current-switching (ZCS) conditions. In this study, the operation principles of the converter are analyzed and the critical design considerations are discussed. The dynamic behavior of the proposed ac-inductor-based TPC is investigated by performing state-space modeling. Moreover, the derived mathematical models are validated by simulation and measurements. In order to verify the validity of the theoretical analysis, design, and power decoupling control scheme, a prototype is constructed and tested under the various modes, depending on the availability of the renewable energy source and the load consumption. The experimental results show that the two decoupled control variables achieve effective regulation of the power flow among the three ports.
Ligand-dependent Activation of the Farnesoid X-receptor Directs Arginine Methylation of Histone H3 by CARM1 (2004)

In this study we demonstrate that the class II nuclear hormone receptor, farnesoid X-receptor (FXR), incorporates histone methyltransferase activity within the gene locus for bile salt export pump (BSEP), a well established FXR target gene that functions as an ATP-dependent canalicular bile acid transporter. This methyltransferase activity is directed specifically to arginine 17 of histone H3. We demonstrate that FXR is directly associated with co-activator-associated arginine methyltransferase 1 (CARM1) activity. Furthermore, we show by chromatin immunoprecipitation that the ligand-dependent activation of the human BSEP locus is associated with a simultaneous increase of FXR and CARM1 occupation. The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP. Consistent with these findings, CARM1 led to increased BSEP promoter activity with an intact FXR regulatory element, whereas CARM1 failed to transactivate the BSEP promoter with a mutated FXRE. Induction of endogenous BSEP mRNA and Arg-17 methylation by FXR regulatory element ligand, CDCA, requires CARM1 activity. Therefore, histone methylation at Arg-17 by CARM1 is a downstream target of signaling through ligand-mediated activation of FXR. Our studies provide evidence that FXR directly recruits specific chromatin modifying activity of CARM1 necessary for full potentiation of the BSEP locus in vivo.
Effects of the antineoplastic alkaloid acronycine on nucleoside uptake and incorporation into nucleic acids by cultured L5178Y cells. (1973)

The antineoplastic alkaloid acronycine inhibits the incorporation of extracellular nucleosides into the RNA and DNA of cultured L5178Y cells. Spectrophotometric and DNA melting temperature studies showed no evidence of an interaction between acronycine and DNA, nor did the drug inhibit the template activity of DNA (when Escherichia coli RNA polymerase was used). Acronycine did not inhibit nucleic acid synthesis in L5178Y cells as measured by the transfer of radioactivity from an intracellular precursor pool prelabeled with radioactive uridine or thymidine into nucleic acids. On the other hand, the alkaloid markedly inhibited the accumulation of extracellular uridine and thymidine as nucleotides in the intracellular precursor pool. Acronycine had no effect on the distribution of radioactivity among the various components ( e.g. , uridine nucleotides) of the acid-soluble pool in cells incubated with uridine-5-3H, and it had little or no effect on the phosphorylation of uridine by cell extracts. It is suggested that the reduced net uptake of uridine may be due to an alteration in the transport of the nucleoside through the plasma membrane. A similar mechanism may be responsible for the inhibition by acronycine of the uptake of other nucleosides ( e.g. , thymidine). Acronycine also strongly reduced the net uptake of formate by L5178Y cells but slightly stimulated the accumulation of 2-deoxyglucose. The immediate biochemical and growth-inhibitory effects of acronycine were readily reversible upon removal of the drug.
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy (2010)

Parkinson's disease (PD) is a prevalent neurodegenerative disorder. Recent identification of genes linked to familial forms of PD such as Parkin and PINK1 (PTEN-induced putative kinase 1) has revealed that ubiquitylation and mitochondrial integrity are key factors in disease pathogenesis. However, the exact mechanism underlying the functional interplay between Parkin-catalyzed ubiquitylation and PINK1-regulated mitochondrial quality control remains an enigma. In this study, we show that PINK1 is rapidly and constitutively degraded under steady-state conditions in a mitochondrial membrane potential-dependent manner and that a loss in mitochondrial membrane potential stabilizes PINK1 mitochondrial accumulation. Furthermore, PINK1 recruits Parkin from the cytoplasm to mitochondria with low membrane potential to initiate the autophagic degradation of damaged mitochondria. Interestingly, the ubiquitin ligase activity of Parkin is repressed in the cytoplasm under steady-state conditions; however, PINK1-dependent mitochondrial localization liberates the latent enzymatic activity of Parkin. Some pathogenic mutations of PINK1 and Parkin interfere with the aforementioned events, suggesting an etiological importance. These results provide crucial insight into the pathogenic mechanisms of PD.
Postgenomic Strategies in Antibacterial Drug Discovery (2010)

During the last decade the field of antibacterial drug discovery has changed in many aspects including bacterial organisms of primary interest, discovery strategies applied and pharmaceutical companies involved. Target-based high-throughput screening had been disappointingly unsuccessful for antibiotic research. Understanding of this lack of success has increased substantially and the lessons learned refer to characteristics of targets, screening libraries and screening strategies. The 'genomics' approach was replaced by a diverse array of discovery strategies, for example, searching for new natural product leads among previously abandoned compounds or new microbial sources, screening for synthetic inhibitors by targeted approaches including structure-based design and analyses of focused libraries and designing resistance-breaking properties into antibiotics of established classes. Furthermore, alternative treatment options are being pursued including anti-virulence strategies and immunotherapeutic approaches. This article summarizes the lessons learned from the genomics era and describes discovery strategies resulting from that knowledge.