gebhart/patrepeval huggingface dataset:
New Opportunities for NDT Using Non-Linear Interaction of Elastic Waves with Defects (2011)

When material is subjected to an intense load, its stiffness changes due to elastic nonlinearity. This effect is especially pronounced in damaged materials, so that nonlinearity can be used as an indication of incipient damage. Under dynamic load, mechanical constraint between the fragments of planar defects provides gigantic nonlinearity in finite-amplitude contact vibrations. The local vibration spectra acquire a number of new frequency components which are used as signatures of damage. The experimental implementation of nonlinear NDT relies on the use of laser interferometers (Nonlinear Laser Vibrometry, NLV) to detect the nonlinear waves that are generated selectively by defects. In addition, the planar defects as localized sources of nonlinear vibrations efficiently radiate nonlinear airborne ultrasound (Nonlinear Air-Coupled Emission, NACE). The frequency conversion mechanism concerned with contact nonlinearity of the defect vibrations provides an efficient generation of air-coupled higher-order ultra-harmonics, ultrasubharmonics, and combination frequencies. Both the NLV and NACE are proposed for remote scanning and high contrast defect-selective imaging in nonlinear NDT.
[Isolated limb perfusion with tumor necrosis factor for malignancies of the limbs]. (1996)

Tumor necrosis factor (TNF) induces rapid necrosis in a variety of experimental neoplasms. However, its clinical application is limited by life-threatening systemic toxicity. Isolated limb perfusion (ILP) enables administration of large doses of TNF and cytotoxic drugs directly to the affected limb, avoiding systemic toxicity. We describe our experience in 20 consecutive patients (10 with melanoma and 10 with soft tissue sarcoma) treated with high-dose TNF and melphalan via ILP. ILP was performed via the external iliac (10 cases), femoral (2), popliteal (5) or brachial (3) vessels. Patients received 3-4 mg TNF to an upper, and 1-1.5 mg/kg to a lower extremity. Isolation efficiency was determined by injection of radiolabelled albumin. The procedure was successful in all 20 patients. Local complications included wound infection in 6 cases and hematoma in 2. 1 patient developed sepsis secondary to extensive necrosis of a large, secondarily infected tumor. The first 6 patients who underwent high-flow perfusion experienced systemic side-effects, mainly hypotension. These side-effects were eliminated when low-flow perfusion was introduced. The response rate was 100%. In the sarcoma group, 5/10 had complete response, and 5 partial response. Amputation or mutilating surgery was avoided in 9/10. Of the 10 with melanoma, 7 had complete, and 3 partial response. We conclude that administration of TNF via ILP is a safe and effective modality for treating advanced neoplasms of the limbs.
[Morphologic assessment of response to neoadjuvant chemotherapy in breast cancer]. (2009)

MP grading system may be one of the prognostic factors in the neoadjuvant therapy of breast cancer.
The <i>Escherichia coli</i> SOS mutagenesis proteins UmuD and UmuD′ interact physically with the replicative DNA polymerase (1999)

The Escherichia coli umuDC operon is induced in response to replication-blocking DNA lesions as part of the SOS response. UmuD protein then undergoes an RecA-facilitated self-cleavage reaction that removes its N-terminal 24 residues to yield UmuD'. UmuD', UmuC, RecA, and some form of the E. coli replicative DNA polymerase, DNA polymerase III holoenzyme, function in translesion synthesis, the potentially mutagenic process of replication over otherwise blocking lesions. Furthermore, it has been proposed that, before cleavage, UmuD together with UmuC acts as a DNA damage checkpoint system that regulates the rate of DNA synthesis in response to DNA damage, thereby allowing time for accurate repair to take place. Here we provide direct evidence that both uncleaved UmuD and UmuD' interact physically with the catalytic, proofreading, and processivity subunits of the E. coli replicative polymerase. Consistent with our model proposing that uncleaved UmuD and UmuD' promote different events, UmuD and UmuD' interact differently with DNA polymerase III: whereas uncleaved UmuD interacts more strongly with beta than it does with alpha, UmuD' interacts more strongly with alpha than it does with beta. We propose that the protein-protein interactions we have characterized are part of a higher-order regulatory system of replication fork management that controls when the umuDC gene products can gain access to the replication fork.
<title>Hard copies for digital medical images: an overview</title> (1995)

This paper is a condensed version of an invited overview on the technology of film hard-copies used in radiology. Because the overview was given to an essentially nonmedical audience, the reliance on film hard-copies in radiology is outlined in greater detail. The overview is concerned with laser image recorders generating monochrome prints on silver-halide films. The basic components of laser image recorders are sketched. The paper concentrates on the physical parameters - characteristic function, dynamic range, digitization resolution, modulation transfer function, and noise power spectrum - which define image quality and information transfer capability of the printed image. A preliminary approach is presented to compare the printed image quality with noise in the acquired image as well as with the noise of state-of- the-art cathode-ray-tube display systems. High-performance laser-image- recorder/silver-halide-film/light-box systems are well capable of reproducing acquired radiologic information. Most recently development was begun toward a display function standard for soft-copy display systems to facilitate similarity of image presentation between different soft-copy displays as well as between soft- and hard-copy displays. The standard display function is based on perceptional linearization. The standard is briefly reviewed to encourage the printer industry to adopt it, too.
Fine-scale mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN 1). (1992)

We have constructed a high-resolution genetic linkage map in the vicinity of the gene responsible for multiple endocrine neoplasia type 1 (MEN1). The mutation causing this disease, inherited as an autosomal dominant, predisposes carriers to development of neoplastic tumors in the parathyroid, the endocrine pancreas, and the anterior lobe of the pituitary. The 12 markers on the genetic linkage map reported here span nearly 20 cM, and linkage analysis of MEN1 pedigrees has placed the MEN1 locus within the 8-cM region between D11S480 and D11S546. The markers on this map will be useful for prenatal or presymptomatic diagnosis of individuals in families that segregate a mutant allele of the MEN1 gene.
Nursing???s Image (2005)

MCN, The American Journal of Maternal/Child Nursing: November 2005 - Volume 30 - Issue 6 - p 415
HealthShare: Using Attribute-Based Encryption for Secure Data Sharing between Multiple Clouds (2017)

In this invited paper, we propose HealthShare - a forward-looking approach for secure ehealth data sharing between multiple organizations that are hosting patients data in different clouds. The proposed protocol is based on a Revocable Key-Policy Attribute-Based Encryption scheme and allows users to share encrypted health records based on a policy that has been defined by the data owner (i.e. patient, a member of the hospital, etc). Furthermore, access to a malicious or compromised user/organization can be easily revoked without the need to generate fresh encryption keys.
Isothermal and Isobaric Desorption of Carbon Dioxide by Purge (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsothermal and Isobaric Desorption of Carbon Dioxide by PurgeShivaji Sircar and Timothy C. GoldenCite this: Ind. Eng. Chem. Res. 1995, 34, 8, 2881–2888Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/ie00047a042https://doi.org/10.1021/ie00047a042research-articleACS PublicationsRequest reuse permissionsArticle Views424Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and Properties of Water-Soluble Squaraine Oligomers Containing Pendant Propanesulfonate Moieties (1998)

Polycondensation of squaric acid with a water-soluble pyrrole derivative containing an N-propanesulfonate pendant group gave a water-soluble A−B type oligomer. Similarly, several water-soluble random oligomers were prepared by the polycondensation of pyrrole, sodium 3-(pyrrol-1-yl)propanesulfonate, and squaric acid. Molecular weight analysis of the new oligomers showed a low degree of polymerization (Mn ∼ 1800−2000) due to the premature precipitation of the condensation products in the reaction medium. Comparison of the IR and 1H NMR spectral data of the new oligomers with those of a model squaraine dye, 9, revealed the presence of zwitterionic squaraine repeat units. The negative solvatochromic property of the polycondensation products and the model compound 9 was analogous to that of several reported squaraine dyes, indicating their structural similarities. Comparison of the solvatochromic properties of the polycondensation products with that of the model dye 9 revealed the oligomeric nature of the polycondensation products. All new oligomers showed enhanced conductivities without external doping when compared to an analogous material without pendant propanesulfonate groups. For example, the conductivity of the condensation product of squaric acid with pyrrole was 1.1 × 10-6 S/cm, whereas that of the condensation product of squaric acid and sodium 3-(pyrrol-1-yl)propanesulfonate was 3.2 × 10-5 S/cm. The enhanced conductivities of the new squaraine oligomers could be due to enhanced conjugation or due to intramolecular doping by the pendant propanesulfonate groups.
PSA-based vaccines for the treatment of prostate cancer (2006)

Prostate cancer is the second leading cause of cancer-related death among men in the USA. Vaccine strategies represent a novel therapeutic approach. One potential target for a prostate cancer vaccine is prostate-specific antigen, owing to its restricted expression in prostate cancer and normal prostatic epithelial cells. A number of prostate-specific antigen-specific epitopes have been identified that can activate cytotoxic T lymphocytes and, in turn, result in the killing of tumor targets by the peptide-specific cytotoxic T lymphocytes. Strategies employed in clinical trials consist of dendritic cell vaccines, recombinant protein and recombinant DNA vaccines, as well as viral vector delivery of vaccines. New approaches incorporating a combination of a vaccine with traditional treatments for prostate cancer are also being investigated.
A Canonical Bit-Sequential Multiplier (1982)

A serial multiplier suitable for VLSI implementation is discussed. The multiplier accepts binary operands supplied in a serial fashion, least significant bits first. The multiplier uses a canonical cell which allows calculation of a 2k length product with only k identical cells. These cells utilize the carry-save addition technique to provide a delay which exhibits only a first-order dependence on the number of bits in the product. The internal logic for generating the inputs to the carry-save adders is given. This cell directly accepts the bit-serial inputs and generates a bit-serial output. Longer binary operands can be multiplied by simply cascading identical cells without change to existing cells. A given multiplier can process shorter operands in correspondingly shorter times. Applicability of this technique to VLSI implementation of the basic multiply/add operation useful in signal processing algorithms is described.
High-efficiency humidity-stable planar perovskite solar cells based on atomic layer architecture (2016)

An ultra-thin ALD Al<sub>2</sub>O<sub>3</sub> architected at the CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3−δ</sub>Cl<sub>δ</sub>/Spiro-OMeTAD interface reduces hysteresis loss and stabilizes perovskite devices against humidity.
“Implant Retained Mandibular Denture: A Case Report” (2010)

The introduction and evolution of dental implants has revolutionized the treatment modalities for replacement of lost natural teeth. Dental professionals are aware of the problems associated with complete mandibular dentures. The denture bearing area for a mandibular denture is three times lesser than for a maxillary denture. In addition, continued residual ridge resorption compromises the retention, stability and support. Today, the minimum standard of care for an edentulous patient is implant supported mandibular overdentures. The insertion of implants for support, retention, and/or stability of an over denture contributes a more favourable environment for the restoration. This case report is of an implant retained mandibular denture using two single piece ball attachment dental implants in the mandibularridge.
Microbial Hydroxylation of Pregnenolone Derivatives (2005)

Pregnenolone and pregnenolone acetate were incubated with the fungi Cunninghamella elegans, Rhizopus stolonifer and Gibberella fujikuroi. Incubation of with C. elegans yielded metabolites, 3beta,7beta,11alpha-trihydroxypreg-5-en-20-one, 3beta,6alpha,11alpha,12beta,15beta-pentahydroxypreg-4-en-20-one and 3beta,6beta,11alpha-trihydroxypreg-4-en-20-one, while incubation with G. fujikuroi yielded two known metabolites, 3beta,7beta-dihydroxypregn-5-en-20-one and 6beta,15beta-dihydroxypreg-4-ene-3,20-dione. Metabolites and were found to be new. Fermentation of by C. elegans yielded four known oxidative metabolites, androsta-1,4-diene-3,17-dione, 6beta,15beta-dihydroxyandrost-4-ene-3,17-dione and 11alpha,15beta-dihydroxypreg-4-ene-3,20-dione. Fermentation of with R. stolonifer yielded two known metabolites, 11alpha-hydroxypreg-4-ene-3,20-dione and. Compounds were screened for their cholinesterase inhibitory activity in a mechanism-based assay.
A CMOS low-distortion switched capacitor oscillator with instantaneous start-up (1984)

Experimental results on the oscillator indicate that good accuracy, low distortion, and instantaneous start-up are achieved. The sinusoidal oscillator has been fabricated in a 3-/spl mu/m CMOS double-poly process. The circuit is ideally suited for audio frequency applications such as DTMF tone generators and FSK modems. Further improvements in accuracy are expected if nonideal effects such as infinite op-amp gain and bandwidth and switch imperfections are taken into account.
Endoskopické operace intrasellárních lézí - naše zkušenosti (2008)

Výhoda přimeho endonazalniho transsfenoidalniho přistupu k
lezim v oblasti tureckeho sedla je v jeho minimalni invazivitě.
Odpada nutnost deviace septa nosniho a nasledne septoplastiky a
dale indoskop zajisťuje větsi přehlednost operacniho pole.
NOD/SCID IL2Rγ-null mouse xenograft model of human p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma using permanent cell lines (2015)

Xenograft models represent a promising tool to study the pathogenesis of hematological malignancies. To establish a reliable and appropriate in vivo model of aggressive human B-cell leukemia and lymphoma we xenotransplanted four p53-mutated cell lines and one ATM-mutated cell line into immunodeficient NOD/SCID IL2Rγ-null mice. The cell lines MEC-1, SU-DHL-4, JEKO-1, REC-1, and GRANTA-519 were transplanted intraperitoneally or subcutaneously and the engraftment was investigated using immunohistochemistry and flow cytometry. We found significant differences in engraftment efficiency. MEC-1, JEKO-1 and GRANTA-519 cell lines engrafted most efficiently, while SU-DHL-4 cells did not engraft at all. MEC-1 and GRANTA-519 massively infiltrated organs and the whole intraperitoneal cavity showing very aggressive growth. In addition, GRANTA-519 cells massively migrated to the bone marrow regardless of the transplantation route. The MEC-1 and GRANTA-519 cells can be especially recommended for in vivo study of p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma, respectively.
Phase Behavior of Weakly Charged Polymer/Surfactant/Water Mixtures (1996)

Ternary phase diagrams have been determined for aqueous mixtures of low-sulfated sodium dextran sulfate (DxS) with penta(ethylene oxide) dodecyl ether (C12E5) containing small amounts of sodium dodecyl sulfate (SDS). A segregative phase separation occurs. A low fraction of charges on either the polymer or the surfactant micelle increases the miscibility considerably, compared to the uncharged reference mixture of Dx and C12E5. Addition of SDS in small steps to DxS/C12E5 (charges on both polyelectrolytes) first leads to a decrease and then to an increase in miscibility. At the minimum in miscibility the effect of charges disappears, and the mixture behaves as an uncharged polymer−surfactant mixture. The trends are interpreted in terms of the entropy of mixing of the dissociated counterions.
Loss of <i>HER2</i> Amplification Following Trastuzumab-Based Neoadjuvant Systemic Therapy and Survival Outcomes (2009)

High pCR rates are achieved in patients with HER2-positive breast cancer treated with neoadjuvant trastuzumab in combination with anthracyclines and taxanes. One third of patients with significant residual disease loses HER2 amplification, and this change is associated with poor RFS. Residual tumor identified at the time of surgery should be reassessed for HER2 status, and novel adjuvant therapy strategies need to be studied in this population.
The Emergence of Bovine Spongiform Encephalopathy and Related Diseases (1998)

Since 1986, approximately 170,000 cases of bovine spongiform encephalopathy (BSE) have occurred among approximately one million animals infected by contaminated feed in the United Kingdom. A ruminant feed ban in 1988 resulted in the rapid decline of the epidemic. Transmissible spongiform encephalopathies due to agents indistinguishable from BSE have appeared in small numbers of exotic zoo animals; a small outbreak among domestic cats is declining. Creutzfeldt-Jakob disease (CJD) has been intensively monitored since 1990 because of the risk BSE could pose to public health. In 1995, two adolescents in the United Kingdom died of CJD, and through the early part of 1996, other relatively young people had cases of what became known as new variant CJD, whose transmissible agent (indistinguishable from that of BSE) is responsible for 26 cases in the United Kingdom and one in France. Areas of concern include how many cases will appear in the future and whether or not use of human blood and blood products may cause a second cycle of human infections.
Models of Mild Traumatic Brain Injury (2014)

Mild traumatic brain injury (TBI) has become a rising epidemic, affecting millions of people each year. Even though it is the most common type of brain injury, our understanding of the science underlying mild TBI is just in its infancy. There has been an explosion of basic science research interest in mild TBI, as emerging clinical evidence is suggestive that concussion and subconcussion may result in detrimental long-term neurological sequelae, particularly when occurring repetitively. Many animal models have been developed to study the different pathological mechanisms implicated in TBI, and more recently there has been a heightened focus on modeling mild TBI in the laboratory as well. The most widely used models of TBI have been adapted for experimental mild TBI research, although more work still remains. The ability to create improved diagnostic measures and treatment approaches for concussion depend on the development and characterization of clinically relevant models of mild TBI. This review aims to provide a broad general overview of the current efforts to model mild TBI in animals and the challenges and limitations that exist in translating this behavioral, physiological, and anatomic knowledge from the bench to the clinical arena.
Harmonics-to-noise ratio as an index of the degree of hoarseness (1982)

Degree of hoarseness can be evaluated by judging the extent to which noise replaces the harmonic structure in the spectrogram of a sustained vowel. However, this visual method is subjective. The present study was undertaken to develop the harmonics-to-noise (H/N) ratio as an objective and quantitative evaluation of the degree of hoarseness. The computation is conceptually straightforward; 50 consecutive pitch periods of a sustained vowel /a/ are averaged; H is the energy of the averaged waveform, while N is the mean energy of the differences between the individual periods and averaged waveform. Recordings of 42 normal voices and 41 samples with varying degrees of hoarseness were analyzed. Two experts rated the spectrogram of each voice sample, based on the amount of noise relative to that of the harmonic component. The results showed a highly significant agreement (the rank correlation coefficient = 0.849) between H/N calculations and the subjective evaluations of the spectrograms. The H/N ratio also proved useful in quantitatively assessing the results of treatment for hoarseness.
Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage. (2005)

This review briefly summarizes the actions of melatonin in reducing molecular damage caused by free radicals and associated oxygen- and nitrogen-based reactants. All the mechanisms by which melatonin is protective of such a wide variety of molecules, i.e. lipids, proteins, DNA, etc., and in such widely diverse areas of the cell and different organs are likely not yet all identified. Melatonin actions that have been identified include its ability to directly neutralize a number of toxic reactants and stimulate antioxidative enzymes. Furthermore, several metabolites that are formed when melatonin neutralizes damaging reactants are themselves scavengers suggesting that there is a cascade of reactions that greatly increase the efficacy of melatonin in styming oxidative mutilation. Suggested, but less well defined, processes which may contribute to melatonin's ability to reduce oxidative stress include stimulation of glutathione synthesis (an important antioxidant which is at high concentrations within cells), reducing electron leakage from the mitochondrial electron transport chain (which would reduce free radical generation), limiting cytokine production and inflammatory processes (actions that would also lower toxic reactant generation), and synergistic effects with other classical antioxidants (e.g. vitamins C, E and glutathione). Clearly which of these multiple mechanisms contribute to melatonin's high efficacy in curtailing oxidative damage remains to be clarified. Likewise, it is possible that the key action of melatonin in reducing molecular damage induced by oxygen and nitrogen-based metabolites remains to be identified. Finally, the review summarizes some of the large amount of data documenting the ability of melatonin to limit molecular and organ damage in two situations, i.e. ischemia-reperfusion and ionizing radiation, where free radicals are generally conceded as being responsible for much of the resulting tissue destruction.