gebhart/patrepeval huggingface dataset:
<title>RF-sensor for a local position measurement system</title> (2003)

In this paper a novel local position measurement (LPM) technology is presented. The LPM system operates in the 5GHz ISM band and consists of lightweight transponders of which the 3-D position is measured, and base stations located around the measurement field. Transponder and base stations operate similar to conventional radar systems and consist of RF electronics as well as signal processing elements. The RF-part in the transponders is the key element for the position measurement system. The measurement accuracy of the LPM system is in the range of some centimeters despite a high measurement rate of 1000 measurements per second.
A Secreted SPRY Domain-Containing Protein (SPRYSEC) from the Plant-Parasitic Nematode<i>Globodera rostochiensis</i>Interacts with a CC-NB-LRR Protein from a Susceptible Tomato (2009)

Esophageal gland secretions from nematodes are believed to include effectors that play important roles in plant parasitism. We have identified a novel gene family encoding secreted proteins specifically expressed in the dorsal esophageal gland of Globodera rostochiensis early in the parasitic cycle, and which contain the B30.2/SPRY domain. The secondary structure of these proteins, named the secreted SPRY domain-containing proteins (SPRYSEC), includes highly conserved regions folding into β-strands interspersed with loops varying in sequence and in length. Mapping sequence diversity onto a three-dimensional structure model of the SPRYSEC indicated that most of the variability is in the extended loops that shape the so-called surface A in the SPRY domains. Seven of nine amino acid sites subjected to diversifying selection in the SPRYSEC are also at this surface. In both yeast-two-hybrid screening using a library from a susceptible tomato and in an in vitro pull-down assay, one of the SPRYSEC interacted with the leucine-rich repeat (LRR) region of a novel coiled-coil nucleotide-binding LRR protein, which is highly similar to members of the SW5 resistance gene cluster. Given that the tomato cultivar used is susceptible to nematode infection, this SPRYSEC could be an evolutionary intermediate that binds to a classical immune receptor but does not yet, or no longer, triggers a resistance response. Alternatively, this SPRYSEC may bind to the immune receptor to downregulate its activity.
Glutathione Conjugation of Alkylating Cytostatic Drugs with a Nitrogen Mustard Group and the Role of Glutathione <i>S</i>-Transferases (1996)

ADVERTISEMENT RETURN TO ISSUEReviewNEXTGlutathione Conjugation of Alkylating Cytostatic Drugs with a Nitrogen Mustard Group and the Role of Glutathione S-TransferasesHubert A. A. M. Dirven, Ben van Ommen, and Peter J. van BladerenView Author Information TNO Nutrition and Food Research Institute, Division of Toxicology, P.O. Box 360, 3700 AJ Zeist, The NetherlandsCite this: Chem. Res. Toxicol. 1996, 9, 2, 351–360Publication Date (Web):February 29, 1996Publication History Received14 August 1995Published online29 February 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/tx950143chttps://doi.org/10.1021/tx950143creview-articleACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views702Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antioxidants,Cells,Conjugate acid-base pairs,Particulate matter,Peptides and proteins Get e-Alerts
Photoacoustic monitoring of burn healing process in rats (2008)

We performed multiwavelength photoacoustic (PA) measurement for extensive deep dermal burns in rats to monitor the healing process of the wounds. The PA signal peak at 532 nm, an isosbestic point for oxyhemoglobin (HbO(2)) and deoxyhemoglobin (HHb), was found to shift to a shallower region of the injured skin tissue with the elapse of time. The results of histological analysis showed that the shift of the PA signal reflected angiogenesis in the wounds. Until 24 h postburn, PA signal amplitude generally increased at all wavelengths. We speculate that this increase in amplitude is associated with dilation of blood vessels within healthy tissue under the injured tissue layer and increased hematocrit value due to development of edema. From 24 to 48 h postburn, the PA signal showed wavelength-dependent behaviors; signal amplitudes at 532, 556, and 576 nm continued to increase, while amplitude at 600 nm, an HHb absorption-dominant wavelength, decreased. This seems to reflect change from shock phase to hyperdynamic state in the rat; in the hyperdynamic state, cardiac output and oxygen consumption increased considerably. These findings show that multiwavelength PA measurement would be useful for monitoring recovery of perfusion and change in local hemodynamics in the healing process of burns.
Molecular recognition and chemistry in restricted reaction spaces. Photophysics and photoinduced electron transfer on the surfaces of micelles, dendrimers, and DNA (1991)

This Account is concerned with molecular recognition in bimolecular reactions1 that occur in restricted spaces. Bimolecular reactions of interest are photoinduced electron transfers for which the reactants are positively electronically excited metal complexes (Figure 1) and another positively charged gegenion, either a metal complex or methyl viologen (MV^(2+)) that serves as an electron acceptor. The restricted reaction spaces are the interfacial regions of anionically charged polyions such as micelles, starburst dendrimers, and DNA. \n\nMolecular recognition is concerned with how specific sites on a molecular receptor are recognized by a binding substrate. Knowledge of the underlying principles of molecular recognition is useful in diverse activities such as the design of site- and conformation-specific reagents for biomolecules, the rational design of drugs and probes of polymer structure, the design of efficient catalytic systems, the design of strategies leading to the synthesis of new materials, and the design of novel nanoscopic devices.
Design and implementation of a distributed applications testbed (2002)

In order for designers and implementers to evaluate interoperability, trade-offs, performance of algorithms, and protocols within distributed applications, experiments are often necessary. Results obtained from experiments can be ultimately used to improve on the performance, efficiency and reliability of the applications during their operations. We propose a general architecture for a distributed applications testbed. This general architecture has emerged from a specific distributed applications testbed for the experimental study of problems related to X.500 distributed directories. Our design and experience suggest that a general architecture and tools can facilitate the development of similar testbeds for other distributed applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rotordynamics analysis of the Space Shuttle main engine high-pressure oxidizer pump (1980)

This study describes the rotordynamics analysis of the Space Shuttle Main Engine (SSME) high-pressure oxidizer turbopump. Modal synthesis methods were used to account for the complex coupling of the pump and engine structure. Cross-coupling elements effecting rotor stability were included in the analysis. Results of the analysis indicated that smaller bearing clearances and a smooth turbine interstage seal would result in longer bearing life and improved stability. Subsequent testing with these design features has shown the same results.
ATM wireless access for mobile multimedia: concept and architecture (1996)

This article discusses the concept and architecture of ATM wireless access for mobile multimedia. Following an overview of wireless ATM, the authors present the concept of ATM wireless access (AWA). This concept is characterized by the following: (1) an ATM transport capability for supporting multimedia services; (2) utilization of the high frequency band for a high-speed transmission capability; (3) limited mobility during communications; and (4) a dual-mode access capability to private as well as public networks. In addition, architectural issues are discussed, including protocol architectures on the control/user (C/U) plane and mobile station architecture. Moreover, the ATM transport architecture is discussed in detail, including the topics of wireless ATM cell configuration, QoS issues, ATM/TDMA conversion over wireless, a timestamp scheme, and QoS-oriented buffer control.
Microholography of Living Organisms (1982)

By using intense pulsed coherent x-ray sources that are currently under development, it will be possible to obtain magnified three-dimensional images of elementary biological structures in the living state at precisely defined instants. For optimum contrast, sensitivity, and resolution, the hologram should be made with x-rays tuned to a resonance of nitrogen near 0.3 nanometer. Resolution will then be limited mainly by the hydrodynamic expansion that occurs while the necessary number of photons is being registered. Problems of technique are also briefly discussed.
Glycogen Synthase Kinase 3β Phosphorylates Alzheimer's Disease-Specific Ser<sup>396</sup> of Microtubule-Associated Protein Tau by a Sequential Mechanism (2006)

Phosphorylation of tau on S(396) was suggested to be a key step in the development of neurofibrillary pathology in Alzheimer's disease brain [Bramblett, G. T., Goedert, M., Jacks, R., Merrick, S. E., Trojanowski, J. Q., and Lee, V. M.-Y. (1993) Neuron 10, 1089-1099]. GSK3beta phosphorylates Ser(396) of tau in the brain by a mechanism which is not clear. In this study, when HEK-293 cells were cotransfected with tau and GSK3beta, GSK3beta co-immunoprecipitated with tau and phosphorylated tau on S(202), T(231), S(396), and S(400) but not on S(262), S(235), and S(404). Blocking phosphorylation on T(231), S(235), S(396), S(400), or S(404) did not prevent the subsequent phosphorylation on S(202) by GSK3beta. These data suggest that GSK3beta directly phosphorylates tau on S(202) (without requiring prephosphorylation). However, preventing phosphorylation on S(235), S(400), and S(404) prevented GSK3beta-dependent phosphorylation of T(231), S(396), and S(400), respectively. This indicates that phosphorylation of T(231), S(396), and S(400) by GSK3beta depends on a previous phosphorylation of S(235), S(400), and S(404), respectively. To examine S(396) phosphorylation, we analyzed phosphorylation of S(396), S(400), and S(404). Blocking phosphorylation of S(404) prevented the subsequent GSK3beta-dependent phosphorylation of both S(400) and S(396). When phosphorylation of S(404) was allowed but S(400) blocked, GSK3beta failed to phosphorylate S(396). Thus, GSK3beta phosphorylates S(396) by a two-step mechanism. In the first step, GSK3beta phosphorylates S(400) of previously S(404)-phosphorylated tau. This event primes tau for second-step phosphorylation of S(396) by GSK3beta. We conclude that GSK3beta phosphorylates tau directly at S(202) but requires the previous phosphorylation on S(235) to phosphorylate T(231). Phosphorylation of S(396), on the other hand, occurs sequentially. Once a priming kinase phosphorylates S(404), GSK3beta sequentially phosphorylates S(400) and then S(396).
A novel quadrilateral-based tracking method (2004)

This paper proposes a novel tracking method based on quadrilateral-based segmentation. The tracking method matches quadrilaterals in a region with those in a reference frame to construct region correspondences, from which trajectory of each region can be obtained. The table tennis sequence has been used to evaluate the tracking method. Experiment results show that the proposed tracking method can track the ping-pong ball and the racket reasonably well over a series of images, indicating matching quadrilaterals to track region is a viable approach.
Factors Affecting the Rate of Hydrolysis of Phenylboronic Acid in Laboratory-Scale Precipitate Reactor Studies (1994)

Removing aromatic carbon from an aqueous slurry of cesium-137 and other alkali tetraphenylborates by acid hydrolysis will be an important step in preparing high-level radioactive waste for vitrification at the Savannah River Site's Defense Waste Processing Facility (DWPF). Kinetic data obtained in bench-scale precipitate hydrolysis reactors suggest changes in operating parameters to improve product quality in the future plant-scale radioactive operation. The rate-determining step is the removal of the fourth phenyl group, i.e. hydrolysis of phenylboronic acid. Efforts to maximize this rate have established the importance of several factors in the system, including the ratio of copper(II) catalyst to formic acid, the presence of nitrite ion, reactions of diphenylmercury, and the purge gas employed in the system.
Calcium fluxes in T lymphocytes. (1992)

Mechanisms controlling Ca2+ fluxes through the plasma membrane of lymphocytes have been characterized in a human T-cell clone and in the Jurkat T-cell line. Due to endogenous buffers, about 1/125 of the Ca2+ ions that enter the cell are free. Ca2+ fluxes were estimated from the variations in intracellular Ca2+ concentration ([Ca2+]i) elicited by concentration jumps in extracellular Ca2+ ([Ca2+]o). Thapsigargin was used to inhibit Ca2+ uptake into intracellular stores and to stimulate Ca2+ entry. Ca2+ extrusion was strictly due to the activity of plasma membrane Ca(2+)-ATPases since there was no detectable Na+/Ca2+ exchange activity in these cells. The rate of Ca2+ extrusion was mainly influenced by [Ca2+]i and less by [Ca2+]o but was insensitive to cell depolarization. In depolarized cells, thapsigargin-induced Ca2+ influx was reduced to 10% of the value measured in normally polarized cells, suggesting that depolarization not only reduces the electrochemical gradient for Ca2+ ions, but also inhibits Ca2+ permeation. When Ca2+ ions enter the cell, they bind to a site inside the channel, with a Kd of 3.3 mM. Stimulation of clonal T-cells with low concentrations of either anti-CD3 antibodies or thapsigargin elicited Ca2+ oscillations. Both the amplitude and the frequency of CD3-induced Ca2+ oscillations were sensitive to [Ca2+]o. These oscillations were immediately interrupted when extracellular Ca2+ was removed. The properties of Ca2+ oscillations in T lymphocytes suggest that they are mainly due to variations of Ca2+ influx, modulated by variations in [Ca2+]i.
Recombinant streptokinase (1993)

(Received 26 July 1993; accepted in revised form 22 September 1993) The author is with the Hematology Unit, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York, USA.
Scalable 3-Stage ATM Switch Architecture Using Optical WDM Grouped Links Based on Dynamic Bandwidth Sharing (1999)

This paper proposes a 3-stage ATM switch architecture that uses optical WDM (wavelength division multiplexing) grouped links and dynamic bandwidth sharing. The proposed architecture has two features. The first is the use of WDM technology which makes the number of cables used in the system proportional to system size. The second is the use of dynamic bandwidth sharing among WDM grouped links. This prevents the statistical multiplexing gain o#ered by WDM from falling even if switching system becomes large. A performance evaluation confirms the scaleability and cost-e#ectiveness of the proposed architecture. It is scaleable in terms of the number of cables and admissible load. We show how the appropriate wavelength signal speed can be determined to implement the switch in a cost-e#ective manner. Therefore, the proposed architecture will suit future high-speed multimedia ATM networks.
Security that is Meant to be Skin Deep: Using Ultraviolet Micropigmentation to Store Emergency-Access Keys for Implantable Medical Devices (2010)

Implantable medical devices, such as implantable cardiac defibrillators and pacemakers, now use wireless communication protocols vulnerable to attacks that can physically harm patients. Security measures that impede emergency access by physicians could be equally devastating. We propose that access keys be written into patients’ skin using ultraviolet-ink micropigmentation (invisible tattoos). 1 The IMD Key Storage Problem Life-critical implantable medical devices (IMDs) are becoming increasingly commonplace. The most familiar, the pacemaker, is implanted into a million patients each year [11] and generates $1.98 billion for market leader Medtronic alone [10, p22]. Implantable cardiac defibrillators
In search of the holy grail of antifungal therapy. (2008)

The ideal antifungal agent remains an elusive goal for treatment of life-threatening systemic fungal infections. Such an agent would have broad antifungal activity, low rates of resistance, flexible routes of administration, few associated adverse events, and limited drug-drug interactions. Only three of the seven classes of antifungal agents currently available are suitable for treatment of systemic infection: the polyenes, the azoles, and the echinocandins. None match all the characteristics of an ideal agent, the Holy Grail of antifungal therapy. Academia and industry need to collaborate in the search for new lead antifungal compounds using traditional screening methods as well as the new pharmacogenomics methods. Enhancing efficacy and reducing toxicity of the currently available therapeutic agents is also another important avenue of study. As an example, the Mycosis Research Center at the University of Mississippi Medical Center has identified pyogenic polyenes in commercial preparations of amphotericin B deoxycholate which correlate with infusion related toxicities. A highly purified formulation of amphotericin B appears promising, with a better therapeutic index compared to its parent compound as evidenced by results of in vitro and in vivo studies reviewed in this presentation.
New Technologies to Prevent Intravascular Catheter-Related Bloodstream Infections (2001)

Most intravascular catheter-related infections are associated with central venous catheters. Technologic advances shown to reduce the risk for these infections include a catheter hub containing an iodinated alcohol solution, short-term chlorhexidine-silver sulfadiazine- impregnated catheters, minocycline-rifampin-impregnated catheters, and chlorhexidine- impregnated sponge dressings. Nontechnologic strategies for reducing risk include maximal barrier precautions during catheter insertion, specialized nursing teams, continuing quality improvement programs, and tunneling of short-term internal jugular catheters.
Correlation signature of the macroscopic states of the gene regulatory network in cancer (2009)

Although cancer types differ substantially, many cancers share common gene expression signatures. Consistent with this observation, we find convergent and representative distributions and correlation vectors that are distinct in cancer and noncancer ensembles. These differences originate in many genes, but comparatively few genes account for the major differences. We identify genes with different combinatorial regulation in cancer and noncancer as indicated by significant differences in their correlation vectors. Among the identified genes are many established oncogenes and apoptotic genes (such as members of the Bcl-2, the MAPK, and the Ras families) and new candidate oncogenes. Our findings expand and complement the tumorigenic role of up and down regulation of these genes by emphasizing cancer-specific changes in their couplings and correlation patterns at genome-wide level that are independent from their mean levels of expression in cancer cells. Given the central role of these genes in defining the cancerous state it may be worth investigating them and the differences in their combinatorial regulation for developing wide-spectrum anticancer drugs.
Li-Rich Li-Si Alloy As A Lithium-Containing Negative Electrode Material Towards High Energy Lithium-Ion Batteries (2015)

Lithium-ion batteries (LIBs) are generally constructed by lithium-including positive electrode materials, such as LiCoO2, and lithium-free negative electrode materials, such as graphite. Recently, lithium-free positive electrode materials, such as sulfur, are gathering great attention from their very high capacities, thereby significantly increasing the energy density of LIBs. Though the lithium-free materials need to be combined with lithium-containing negative electrode materials, the latter has not been well developed yet. In this work, the feasibility of Li-rich Li-Si alloy is examined as a lithium-containing negative electrode material. Li-rich Li-Si alloy is prepared by the melt-solidification of Li and Si metals with the composition of Li21Si5. By repeating delithiation/lithiation cycles, Li-Si particles turn into porous structure, whereas the original particle size remains unchanged. Since Li-Si is free from severe constriction/expansion upon delithiation/lithiation, it shows much better cyclability than Si. The feasibility of the Li-Si alloy is further examined by constructing a full-cell together with a lithium-free positive electrode. Though Li-Si alloy is too active to be mixed with binder polymers, the coating with carbon-black powder by physical mixing is found to prevent the undesirable reactions of Li-Si alloy with binder polymers, and thus enables the construction of a more practical electrochemical cell.
High transparency and toughness PMMA nanocomposites toughened by self-assembled 3D loofah-like gel networks: fabrication, mechanism, and insight into the in situ polymerization process (2016)

Novel transparent PMMA composites were toughened with 3D loofah-like gel networks obtained <italic>via in situ</italic> polymerization of methyl methacrylate gel with POSS-based supramolecular POSS-Lys(BOC) gelators.
IEEE Standard Boundary Scan 1149.1 An Introduction (1991)

With increased system packaging density, testability advantages of scan design were applied to IC boundary pins for ensured pin access where direct physical contact was becoming increasingly difficult. As the advantages of boundary-scan were becoming recognized in many commercial applications, it became apparent that a universal definition was needed to achieve the economies of using an industry standard. This led to the 1990 approval of IEEE Standard 1149. 1.