gebhart/patrepeval huggingface dataset:
Studies on the anti-phospholipase A2 and anti-inflammatory activities of a uteroglobin fragment and related peptides. (1993)

The nonapeptide antiflammin P1 (H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH), its isoAsp8 analogue and the corresponding aminosuccinyl peptide were prepared, characterized and tested for inhibition of phospholipase A2 (PLA2) in vitro and for anti-inflammatory activity in vivo under assay conditions recently recommended. All peptides are devoid of PLA2 inhibitory and anti-inflammatory activity.
Photogrammetric Recession Measurements of Ablative Materials in the NASA Ames Sixty-Megawatt Arcjet (2007)

The photogrammetric recession measurement (PRM) technique has been applied in several tests of ablative thermal-protection system materials in the 60-MW arcjet at NASA Ames Research Center. This paper presents selected results from those tests to illustrate the capabilities and limitations of the technique.
Effect of WC Grain Size on the Abrasive Wear Resistance of HVOF Spraying WC-Co Coatings (2010)

Three different WC grain size powder were used to prepare WC-Co coatings employing HVOF technique. The effect of WC grain size on the abrasive wear resistance and failure mechanism were analyzed. The results show that the abrasive wear resistance increases with the decrease of WC grain size. Nanostructured coating is high in surface plasticity. It can only be pressed out of prints, the opportunity of cutting is small. Micro-cutting wear dominates the main abrasive wear mechanism of nanostructured coating.
Synthesis of Nano-Calcium Oxide from Waste Eggshell by Sol-Gel Method (2019)

The sol-gel technique has many advantages over the other mechanism for synthesizing metal oxide nanoparticles such as being simple, cheap and having low temperature and pressure. Utilization of waste materials as a precursor for synthesis makes the whole process cheaper, green and sustainable. Calcium Oxide nanoparticles have been synthesized from eggshell through the sol-gel method. Raw eggshell was dissolved by HCl to form CaCl2 solution, adding NaOH to the solution dropwise to agitate Ca (OH)2 gel and finally drying the gel at 900 °C for 1 h. The synthesized nanoparticle was characterized by scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR), X-Ray fluorescence (XRF) and X-ray diffraction (XRD). The FTIR and XRD results have clearly depicted the synthesis of calcium oxide from eggshell, which is mainly composed of calcium carbonate. The FE-SEM images of calcium oxide nanoparticles showed that the particles were almost spherical in morphology. The particle size of the nanoparticles was in the range 50 nm–198 nm. Therefore, waste eggshell can be considered as a promising resource of calcium for application of versatile fields.
EXPERTS CO‐OPERATE FOR FLEXIBLE ASSEMBLY (1992)

Knowledge‐based programming has provided a paradigm for the development of more effective and robust systems in a variety of fields. Its application to flexible assembly systems (FAS) clearly has its origins and continues to receive impetus from the close historical links between the academic disciplines of Artificial Intelligence and Robotics. In this article some of its potential benefits to assembly systems are examined within the context of a SERC/ACME‐funded research project carried out at The University of Wales, Aberystwyth. The STAR project explored the potential of a variety of knowledge‐based systems in a number of roles and demonstrated how they might co‐operate. Some of these concepts were further explored and applied in the subsequent EUREKA/FAMOS project known as InFACT.
Population Pharmacokinetic (PK) Evaluation and Missed Dose Simulations for Eslicarbazepine Acetate (ESL) Monotherapy (P4.258) (2015)

OBJECTIVE: To determine the effect on plasma and cerebrospinal fluid (CSF) eslicarbazepine PK of missing an ESL dose during monotherapy. BACKGROUND: ESL is approved as adjunctive therapy (but not as monotherapy) for partial-onset seizures. The effect of missing a dose of ESL on plasma and CSF eslicarbazepine concentrations is unknown. DESIGN/METHODS: Plasma eslicarbazepine PK was determined from Phase I and III trials; CSF concentrations were also available from 6 healthy subjects. A peripheral (CSF) compartment was added to the previously developed plasma PK model for eslicarbazepine, with plasma parameters and covariate effects fixed to estimates from the Phase I/III studies used for model development. Stochastic simulations of 1200 ‘virtual’ monotherapy patients were performed for eleven missed dose scenarios, using the final PK model. RESULTS: CSF eslicarbazepine concentrations were adequately predicted by a two-compartment model with first-order absorption/elimination. Typical parameter values ([percnt] SEM) for drug transfer in and out of CSF from plasma were 0.018/h (91.4) and 0.145/h (15.2), respectively; apparent CSF distribution volume was 16.9 L (81.2). In simulations, when dosing was delayed by 12-16 or 36-42 h, plasma concentrations were maintained within the target range by immediate administration of a 1600 mg dose, followed by an additional dose 6-12 h later. A delay in dosing of 20, 24 or 48 h required 1.5 times the proposed maximum monotherapy dose (1600 mg) to achieve plasma concentrations equivalent to those produced when dosing was on time. When dosing was delayed by 12-44 hours, following the dosing pattern for plasma, CSF concentrations remained above those achieved without delayed dosing for most of the dosing interval. CONCLUSIONS: Eslicarbazepine CSF concentration time profiles were adequately predicted by an exploratory two-compartment model. Simulations of missed dose scenarios provided information on the predicted impact on plasma and CSF concentrations.
Eigenvector-Based Feature Extraction for Classification (2002)

This paper shows the importance of the use of class information in feature extraction for classification and inappropriateness of conventional PCA to feature extraction for classification. We consider two eigenvector-based approaches that take into account the class information. The first approach is parametric and optimizes the ratio of between-class variance to within-class variance of the transformed data. The second approach is a nonparametric modification of the first one based on local calculation of the between-class covariance matrix. We compare the two approaches with each other, with conventional PCA, and with plain nearest neighbor classification without feature extraction. 1.
Development of an advanced continuous mild gasification process for the production of co-products: Topical report (1988)

This report covers the technical efforts completed over a four month period by UCC Research Corporation (UCCRC) on Task 1, ''Literature Survey and Market Assessment'' of the project. The overall objective is to develop the technology for a continuous mild gasification process which will yield quantities and properties of co-products that can be profitably produced on a commercial scale. There were four steps taken: (1) A Literature Survey was made to determine what processes had been developed and how co-products could be upgraded to have a greater economic value; (2) Market assessments were made, one which covered the use of char and coal liquids for gas turbine only and the second which covered various markets for all co-products (char, liquid and gas); (3) A Technical Advisory Panel was convened to review information from the literature survey and from the market assessments to review all probable factors involved in selecting a suitable process to be developed; and (4) The most promising process was selected after completion of the previous three steps. Results are discussed. (158 refs., 61 figs., 66 tabs.)
PLASMA TEMPERATURE: RELATIVE INTENSITY OF SPECTRAL LINES (1962)

ABS>Successive temperature measurements on the plasma jet, which is adjusted to similar conditions, indicate that the precision of this method is within plus or minus 1% in the temperature range of 5000 to 6000 deg K. This precision is attributed to the adopted technique of placing both calibration information and test data on each spectrograph plate and thus eliminating the photographic variables. (auth)
Nuclear magnetic resonance studies of hemoglobins. VII. Tertiary structure around ligand binding site in carbonmonoxyhemoglobin (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNuclear magnetic resonance studies of hemoglobins. VII. Tertiary structure around ligand binding site in carbonmonoxyhemoglobinTed R. Lindstrom, Ingrid B. E. Noren, Samuel Charache, Hermann Lehmann, and Chein HoCite this: Biochemistry 1972, 11, 9, 1677–1681Publication Date (Print):April 1, 1972Publication History Published online1 May 2002Published inissue 1 April 1972https://pubs.acs.org/doi/10.1021/bi00759a023https://doi.org/10.1021/bi00759a023research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimum Synthesis of Wide-Band Parametric Amplifiers and Converters (1961)

This paper derives the theoretical limitation on gain and bandwidth for parametric amplifiers and inverting-type up-converters. It shows that the transducer power gain of an amplifier or a converter can be related to the reflection coefficient of a simple matching network as <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G_a \approx \frac {\omega_0} {\omega_{0}\prime} G_c \aaprox \frac {1} {4 |p|^2}</tex> where <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G_a</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G_c</tex> are the power gain of the amplifier and the converter, respectively, <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\omega_0</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\omega_0 \prime</tex> are the center frequencies of the signal and the idler bands, respectively, and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\rho</tex> is the reflection coefficient which is limited in bandwidth by the following formula: <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\frac {B} {\omega_0} \ln \arrowvert \frac {1} {\rho} \arrowvert \leq \frac {\pi} {2} \frac {C_1} {C_0} \sqrt{\frac {\omega_0 \prime} {\omega_0}}</tex> <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</tex> is the bandwidth, and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C_0 + 2 C_1 \cos\overline{\omega} t</tex> represents the variable capacitance. Optimum Butterworth filters are used as the coupling networks. Condition for optimum matching is determined together with element values of the circuit. The theoretical limitation on bandwidth can be approached if the number of elements in the coupling network is increased. The design of optimum wide-band amplifiers and converters becomes straightforward, thus eliminating any cut and try process.
Multiple Marker Evaluation in Prostatic Cancer Using Prostatic Specific Antigen, Gamma-Seminoprotein and Prostatic Acid Phosphatase (1989)

Serum prostatic specific antigen (PA), gamma-seminoprotein (gamma-Sm) and prostatic acid phosphatase (PAP) were evaluated in 141 patients with prostatic cancer, 121 of whom were newly diagnosed. Of the 121 untreated patients, 77, 71 and 67% were detectable by the PA, gamma-Sm and PAP markers, respectively. PA was equally or more sensitive in all stages than the other two markers. Using the benign prostatic hypertrophy group (131 patients) as a negative control, the specificities of PA, gamma-Sm and PAP were 89, 76 and 83%, respectively. Combination of PA, gamma-Sm and PAP increased sensitivity to 86%, especially in localized disease (stages A, B and C) to 74%, but did not improve specificity (67%) or efficiency (76%). During the follow-up period of 1-53 months, 24 of 141 patients with prostatic cancer had disease progression. All serial levels of gamma-Sm, PA, and PAP were positive in 17, 12 and 10 of the 24 patients within 6 months prior to detectable disease progression. gamma-Sm appeared to be more sensitive than the other two markers for early detection of disease progression. These results suggest that PA and gamma-Sm are reliable markers for detection and monitoring of prostatic cancer.
Dynamic tuning of PI-controllers based on model-free Reinforcement Learning methods (2010)

A Reinforcement Learning (RL) method called SARSA is used to dynamically tune a PI-controller for a Continuous Stirred Tank Heater (CSTH) experimental setup. In order to start from an acceptable policy, the proposed approach uses an approximate First Order Plus Time Delay (FOPTD) model to train the RL agent in the simulation environment before implementation on the real plant. As a result of the existing plant-model mismatch, the performance of the RL-based PI-controller based on the policy derived from simulations is not as good as the simulation results; however, training on the real plant results in a significant performance improvement. On the other hand, the IMC-tuned PI-controllers, which are the most commonly used feedback controllers, degrade because of the inevitable plant-model mismatch. The experimental tests are carried out for the cases of set-point tracking and disturbance rejection. In both cases, the successful adaptability of the RL-based PI-controller is clearly evident.
Dobutamine echocardiography and myocardial contrast echocardiography. Two new techniques for the assessment of myocardial viability. (1995)

As investigators have discovered that cardiac regions displaying resting wall motion abnormalities are not the necessary equivalent of myocardial scar (and therefore of irreversible injury) but are potentially viable regions rendered dysfunctional by stunning or hibernation, a new field of medicine has developed to identify viable myocardium that can improve in function after revascularization. Moreover, improvements in myocardial preservation and perfusion during coronary artery bypass grafting and percutaneous transluminal coronary angioplasty have enabled patients with poor resting ejection fractions to undergo safer revascularization. In this review, we describe briefly the diagnostic techniques most commonly used in identifying dysfunctional but viable myocardium. We give specific attention to the assets and limitations of these techniques and special emphasis to 2 promising new techniques: dobutamine echocardiography and myocardial contrast echocardiography.
A Sub-10-ps Multiphase Sampling System Using Redundancy (2005)

This paper demonstrates a multichannel multiphase sampling system using a 700-MHz operating frequency to produce a base sampling rate of 7 GSample/s for each channel in a typical 0.18-/spl mu/m CMOS technology. An extra phase cluster with <10-ps sampling phase spacing is generated. To achieve this small phase spacing, static phase and voltage errors are digitally calibrated. Additionally, a redundancy technique is introduced in this paper to further halve the residual voltage error of the samplers. A third technique, i.e., "reference subtraction," is applied to remove cross-channel correlated dynamic noise. The resulting phase spacing is only limited by the uncorrelated random noise in the system. With this fine sampling phase resolution, this system has the ability to measure cycle-to-cycle jitter in real time.
CD8+ T CELLS ARE CAPABLE OF REJECTING PANCREATIC ISLET XENOGRAFTS1, 2 (2000)

The results demonstrate that, in the absence of CD4+ T cells, CD8+ T cells were capable of rejecting both rat and pig pancreatic islet xenografts.
Severity of the ductal shunt: a comparison of different markers (2005)

This study indicates that LA/Ao ratio, DA diameter, and mean and end diastolic flow velocity of the LPA are accurate markers of PDA. These standard echocardiographic variables are easy to measure and need less skill and resources than direct measurements of ductal shunt.
Antithrombin III Prevents and Rapidly Reverses Leukocyte Recruitment in Ischemia/Reperfusion (1997)

This study demonstrates for the first time that thrombin plays an important role in ischemia-induced leukocyte rolling and adhesion and that ATIII can be used therapeutically postreperfusion to attenuate the leukocyte recruitment response in inflammation without the nonspecific effects associated with anti-adhesion molecule therapy.
AMP-activated protein kinase and hepatic genes involved in glucose metabolism (2003)

Mammalian AMP-activated protein kinase presents strong structural and functional similarities with the yeast sucrose non-fermenting 1 (Snf1) kinase involved in the derepression of glucose-repressed genes. It is now clearly established that AMP-activated protein kinase in the liver decreases glycolytic/lipogenic gene expression as well as genes involved in hepatic glucose production. This is achieved through a decreased transcriptional efficiency of transcription factors such as sterol-regulatory-element-binding protein-1c, carbohydrate-response-element-binding protein, hepatocyte nuclear factor 4 alpha or forkhead-related protein. Clearly, the long-term consequences of AMP-activated protein kinase activation have to be taken into account if activators of this enzyme are to be designed as anti-diabetic drugs.
Geological and Geophysical Characteristics of the New Hebrides Basin (1997)

The New Hebrides Basin is an inactive non back-arc basin located at the convergent boundary of the Pacific and Info-Australian plates. This basin was formed from 46 Ma to 60 Ma. The basin has two spreading episodes with rates of 34 mm/a for 42 to 47 Ma and 17 mm/a for 47 to 60 Ma. The sediments covered in the basin has uniform thickness of 0.65 sec. The age-depth correlation curve of the New Hebrides Basin can be represented by the following equation: The coefficient of 312 in this equation is close to that for major oceans, 350. This suggests that the cooling processes of the lithospheres in the New Hebrides Basin and major oceans are similar to each other. Free-air gravity anomalies of the basin varying from -22.3 mgal to +59.0 mgal. The mean value is +30.2 mgal higher than those of the normal oceans. Moderately large free-air gravity anomalies in the New Hebrides Basin are presumably owing to its location on a marginal swell along the New Hebrides Trench. It is generally observed that the ocean floor is very gently uplifted in a zone about 200 km oceanward of the trench axis. Positive free-air gravity anomalies amounting to mgal are usually observed on the crest of the swell. This topography is presumably by bending of the oceanic lithosphere so as to dynamically maintain nonisostatic states for some duration.
A Simple Copper Catalyst for Both Aziridination of Alkenes and Amination of Activated Hydrocarbons with Chloramine-T Trihydrate (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA Simple Copper Catalyst for Both Aziridination of Alkenes and Amination of Activated Hydrocarbons with Chloramine-T TrihydrateDavid P. Albone, Pavandeep S. Aujla, , Stephen Challenger, and Andrew M. DerrickView Author Information Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK Pfizer Central Research, Sandwich, Kent, CT13 9NJ, UK Cite this: J. Org. Chem. 1998, 63, 25, 9569–9571Publication Date (Web):November 14, 1998Publication History Received9 July 1998Published online14 November 1998Published inissue 1 December 1998https://pubs.acs.org/doi/10.1021/jo981335qhttps://doi.org/10.1021/jo981335qbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views2156Altmetric-Citations144LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aziridines,Catalysts,Chemical reactions,Hydrocarbons,Organic reactions Get e-Alerts
Treatment of anthrax infection with combination of ciprofloxacin and antibodies to protective antigen of<i>Bacillus anthracis</i> (2003)

Currently there is no effective treatment for inhalational anthrax beyond administration of antibiotics shortly after exposure. There is need for new, safe and effective treatments to supplement traditional antibiotic therapy. Our study was based on the premise that simultaneous inhibition of lethal toxin action with antibodies and blocking of bacterial growth by antibiotics will be beneficial for the treatment of anthrax. In this study, we tested the effects of a combination treatment using purified rabbit or sheep anti-protective antigen (PA) antibodies and the antibiotic ciprofloxacin in a rodent anthrax model. In mice infected with a dose of Bacillus anthracis Sterne strain corresponding to 10 LD(50), antibiotic treatment with ciprofloxacin alone only cured 50% of infected animals. Administration of anti-PA IgG in combination with ciprofloxacin produced 90-100% survival. These data indicate that a combination of antibiotic/immunoglobulin therapy is more effective than antibiotic treatment alone in a rodent anthrax model.
Microbial Reduction of Ketopantoyl Lactone to Pantoyl Lactone (1974)

The results of a microbial survey study have shown that the ability to reduce added ketopantoic acid (or ketopantoyl lactone) and accumulate pantoic acid (or pantoyl lactone) in the growth medium is widespread among diverse fungi. The reductions generally proceeded with less than full stereoselectivity. However, specific strains of the ascomycete Byssochlamys fulva were found to form D[-]-pantoic acid in unusually high yields and optical purity.