gebhart/patrepeval huggingface dataset:
Effects of root‐end filling materials and eugenol on mitochondrial dehydrogenase activity and cytotoxicity to human periodontal ligament fibroblasts (2004)

Various root-end filling materials have been used to prevent the entry of root-canal pathogens into periapical regions. Five root-end filling materials were compared regarding the cytotoxicity, apoptosis, and mitochondrial dehydrogenase (MDH) activities of human periodontal ligament (PDL) fibroblasts, with the use of a novel transwell culture system. Exposure to IRM (a ZnO eugenol-based intermediate restorative material), a 2-ethoxybenzoic acid cement (Super EBA), and amalgam for 3 days inhibited the MDH activity of PDL fibroblasts as indicated by decrease in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) reduction by 97%, 95%, and 51%, respectively. Evident suppression of MTT reduction by amalgam and glass ionomer cement (GIC) was noted after 5 days of exposure, with 73% and 46% of inhibition, respectively. Mineral trioxide aggregates (MTA) showed little effect on MDH activity. IRM and Super EBA were cytotoxic to PDL fibroblasts as indicated by a trypan blue dye exclusion technique. GIC and amalgam showed mild cytotoxicity. IRM, GIC, and amalgam further induced apoptosis of PDL cells, as revealed by the presence of sub-G0/G1 DNA content in flow cytometric histogram. Twenty-four-hour exposure to IRM and Super EBA elevated the MDH activities to 156% and 117%, correspondingly, of that of control. Eugenol, a phenolic ingredient in Super EBA and IRM, also increases MDH activity of PDL fibroblasts by 45% and 51%, at concentrations of 0.5 and 1 mM. However, at concentrations higher than 0.5 mM, eugenol decreased the number of viable PDL fibroblasts. These results suggest that MTA is a biocompatible root-end filling material, followed by self-curing Fuji II GIC and amalgam. IRM and Super EBA ingredients induced marked cytotoxicity and transiently stimulate MDH activities, which is possibly due to their content of eugenol and induction of cellular adaptive response.
Probucol Protects Against Adriamycin Cardiomyopathy Without Interfering With Its Antitumor Effect (1995)

These data show for the first time that PROB can provide complete protection against ADR cardiomyopathy without interfering with antitumor properties of the drug. This protective effect of PROB may be related to the maintenance of the antioxidant status of the heart.
Pilot symbol assisted modulation in fading and delay spread (2002)

The performance of pilot symbol assisted modulation (PSAM) is analyzed in intersymbol interference (ISI) due to frequency selective fading. PSAM is shown to be sensitive to RMS delay spread, though it always gives better performance than differential detection.
Dynamic TDD support in the LTE-B enhanced Local Area architecture (2012)

The Third Generation Partnership Project (3GPP) has been studying dynamic allocation of sub-frames to uplink (UL) or downlink (DL) in Time Division Duplex (TDD), called `Dynamic TDD,' since the Long Term Evolution (LTE) Rel. 11 timeframe. At the same time, 3GPP is also standardizing Enhanced Local Area (eLA) small-cell heterogeneous architectures for inclusion in LTE-B (LTE Rel. 12) as a solution offering high data rate to user terminals (UEs) along with high system capacity through spatial reuse of spectrum. In this paper, we focus on a particular eLA architecture proposed by DOCOMO, called the Phantom Cell architecture, that has the option to support dynamic TDD. For an arbitrarily-located UE in an eLA cell network, we apply results from stochastic geometry to derive expressions for the distribution of DL signal to interference plus noise ratio (SINR) at an arbitrary UE and the distribution of UL SINR at its serving eLA base station (BS). We use these results to study aspects of eLA cell system design, and the sensitivity of SINR to the extent of coordination across eLA cells employing dynamic TDD.
Stereospecific Glycosylation via Ferrier Rearrangement for Optical Resolution (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific Glycosylation via Ferrier Rearrangement for Optical ResolutionBimal K. Banik, Maghar S. Manhas, and Ajay K. BoseCite this: J. Org. Chem. 1994, 59, 17, 4714–4716Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://doi.org/10.1021/jo00096a004RIGHTS & PERMISSIONSArticle Views484Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (358 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Infrared Absorption of Germanium near the Lattice Edge (1955)

Received 10 December 1954DOI:https://doi.org/10.1103/PhysRev.97.1714.2©1955 American Physical Society
Kinetic isotope effects for hydrogen diffusion in bulk nickel and on nickel surfaces (1990)

Diffusion coefficients for H, D, and T on a Ni(100) surface and in bulk Ni are calculated using variational transition state theory with semiclassical ground-state transmission coefficients using two potential energy surfaces obtained by the embedded atom method (EAM). The original EAM potential reproduces experimental bulk diffusion coefficients, but greatly overestimates the diffusion coefficients for H and D on Ni(100). By refining the empirical potential parameters, a new EAM potential is developed that accurately reproduces both the bulk and surface diffusion coefficients. The variational transition state theory calculations are used to analyze the unusually low (compared to gas phase) H/D kinetic isotope effects for diffusion in bulk and on the Ni(100) surface. For the temperature range for which experiments have been carried out, quantum mechanical tunneling contributes negligibly to the diffusion and, in these cases, the kinetic isotope effect is determined largely by the change in zero-point energy between the reactant equilibrium binding sites and the transition state. A near equality of the reactant and transition state zero-point energies leads to the unusually low kinetic isotope effects. Using the same refined EAM potential energy surface, the energetics of diffusion on the Ni(111) and Ni(110) surfaces are also presented. The barriers for diffusion on these two surfaces are sufficiently low, about 1.0 kcal/mol, that the approximation of uncorrelated hops needed to relate the computed hopping rate to the diffusion coefficient is suspect. Although diffusion coefficients were not computed, based upon an analysis of the zero-point energies at the reactants and saddle points, we predict that the H/D kinetic isotope effects for diffusion on these two surfaces will also be close to unity.
Algorithms and Hardware for Reasoning in Factor Graphs (2015)

This thesis investigates factor graphs and their applications. Factor graphs can be used to mimic the brain's operation in a massively-parallel distributed system. We present the evolution of our factor graph from a PC-based implementation to embedded factor graphs that run on two different dedicated hardware systems: a SpiNNaker and an SoC. We can transform them into reconfigurable computing machines that will be very useful for developing robotic systems with cognitive capabilities.
A low power VLSI architecture of SOVA-based turbo-code decoder using scarce state transition scheme (2000)

In this paper, we propose a low power VLSI architecture of Soft-Output-Viterbi-Algorithm (SOVA) based turbo-code decoder using a scarce state transition scheme (SST). A register exchange survival memory unit (RE-SMU) and systolic block are used in the implementation of SOVA for high throughput and low latency. SST is used to reduce the power consumption. Simulation results show that the power consumption of RE-SMU and the systolic block is reduced significantly. The power consumption of the add-compare-select (ACS) block is also reduced by as much as 20% after 4 iterations of turbo-code decoding.
TIE2-expressing monocytes as a diagnostic marker for hepatocellular carcinoma correlates with angiogenesis (2012)

TEMs increase in patients with HCC and their frequency changes with the therapeutic response or recurrence. We thus suggest that TEM frequency can be used as a diagnostic marker for HCC, potentially reflecting angiogenesis in the liver.
Drag reduction in pipes lined with riblets (1990)

In the present paper, experiments are reported establishing a maximum drag reduction of five to seven percent in fully developed turbulent flow of water through 25.4mm and 50.8mm diameter pipes lined with a film of grooved equilateral triangles of base 0.11mm. The maximum reduction occurs when the height of the riblets is 11 to 16 wall units. This correlates well with the Taylor microscale of the fluctuating velocity gradient.
KMS: a distributed hypermedia system for managing knowledge in organizations (1988)

Developers of hypermedia systems face many design issues. The design for KMS, a large-scale hypermedia system for collaborative work, seeks improved user productivity through simplicity of the conceptual data model.
Optimization of Object-Image Distance for Aberration and Space-Charge Effect in Symmetric Magnetic Doublet with Dynamically Compensated Field Aberrations (1995)

Maximum beam currents are expected when the optimum object-image distances and beam semiangle are 840 mm and 0.53 mrad, 840 mm and 0.27 mrad, and 1008 mm and 0.16 mrad for the subfield sizes of 250, 500, and 1000 µ m squares, respectively, where main field size, beam energy, energy width, and beam blur specifications are assumed to be 20 mm, 100 keV, 3 eV, and 45 nm, respectively, and the space-charge effect is assumed to be proportional to the object-image distance, beam current and (beam semiangle) -1 . The residual distortions after correction of the beam rotation and position are 5.2, 7.6, and 6.6 nm for the above respective object-image distance and field size conditions.
An enzyme-linked immunosorbent assay for diagnostic detection of Taenia saginata copro-antigens in humans (1991)

An immunodiagnostic sandwich enzyme-linked immunosorbent assay (ELISA) was developed for the detection of soluble Taenia saginata antigens in stool samples (copro-antigens) of infected humans, using affinity-purified polyclonal antibodies obtained from rabbits hyperimmunized with excretory/secretory antigens derived from T. saginata maintained in vitro. Investigation of operating characteristics showed very low cross-reactivity with crude antigens from helminths other than Taenia, including Dipylidium caninum and Diphyllobothrium latum. The specificity of the assay was 95% when testing stool samples from 100 persons who were either infected with Ascaris lumbricoides, Trichuris trichiura, hookworms, Enterobius vermicularis or Hymenolepis nana, or who had no intestinal helminthosis detected. Analysis of diagnostic sensitivity demonstrated that in 85% of 34 samples from 23 untreated persons with intestinal T. saginata infection (selected by previous proglottid and/or egg detection) copro-antigens were detected by the T. saginata ELISA. In the same samples, Taenia eggs were detected in 62%. Only 41% of the samples reacted positively in a heterologous T. hydatigena ELISA. Post-treatment control revealed a high concentration of T. saginata copro-antigens for 1-4 d after administration of niclosamide or praziquantel, and negative values 9-17 d after treatment. The Taenia copro-antigens remained detectable by ELISA even after storage of untreated faeces at 25 degrees C for at least 5 d.
Dry efficient cleaning of poly-methyl-methacrylate residues from graphene with high-density H2 and H2-N2 plasmas (2015)

Graphene is the first engineering electronic material, which is purely two-dimensional: it consists of two exposed sp2-hybridized carbon surfaces and has no bulk. Therefore, surface effects such as contamination by adsorbed polymer residues have a critical influence on its electrical properties and can drastically hamper its widespread use in devices fabrication. These contaminants, originating from mandatory technological processes of graphene synthesis and transfer, also impact fundamental studies of the electronic and structural properties at the atomic scale. Therefore, graphene-based technology and research requires “soft” and selective surface cleaning techniques dedicated to limit or to suppress this surface contamination. Here, we show that a high-density H2 and H2-N2 plasmas can be used to selectively remove polymeric residues from monolayer graphene without any damage on the graphene surface. The efficiency of this dry-cleaning process is evidenced unambiguously by a set of spectroscopic and microscopic methods, providing unprecedented insights on the cleaning mechanisms and highlighting the role of specific poly-methyl-methacrylate residues at the graphene interface. The plasma is shown to perform much better cleaning than solvents and has the advantage to be an industrially mature technology adapted to large area substrates. The process is transferable to other kinds of two-dimensional material and heterostructures.
Magnetic properties of randomly dispersed magnetic particulate composites: A theoretical study (2005)

The overall magnetic properties of magnetic particle-filled composites are studied with the consideration of direct magnetic interactions between randomly dispersed particles. The local magnetic field for two particles embedded in the infinite medium is solved and the pairwise magnetic particle interaction is defined. Integrating the pairwise interactions from all particles provides the homogenized magnetic fields, from which the effective magnetic permeability is derived. If the particle interaction is dropped, the result is reduced to Maxwell-Garnett's model.
Spatial mapping of integrin interactions and dynamics during cell migration by Image Correlation Microscopy (2004)

Image correlation microscopy methodology was extended and used to determine retrospectively the density, dynamics and interactions of alpha5-integrin in migrating cells. Alpha5-integrin is present in submicroscopic clusters containing 3-4 integrins before it is discernibly organized. The integrin in nascent adhesions, as identified by the presence of paxillin, is approximately 1.4 times more concentrated, approximately 4.5 times more clustered and much less mobile than in surrounding regions. Thus, while integrins are clustered throughout the cell, they differ in nascent adhesions and appear to initiate adhesion formation, despite their lack of visible organization. In more mature adhesions where the integrin is visibly organized there are approximately 900 integrins microm(-2) (about fivefold higher than surrounding regions). Interestingly, alpha5-integrin and alpha-actinin, but not paxillin, reside in a complex throughout the cell, where they diffuse and flow together, even in regions where they are not organized. During adhesion disassembly some integrins diffuse away slowly, alpha-actinin undergoes a directed movement at speeds similar to actin retrograde flow (0.29 microm min(-1)), while all of the paxillin diffuses away rapidly.
A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans. (1993)

A >23-kb gene that encodes a large integral membrane protein with a predicted structure similar to that of the low density lipoprotein (LDL) receptor-related protein (LRP) of mammals has been isolated and sequenced from the free-living nematode Caenorhabditis elegans. The 4753-amino acid predicted C. elegans product shares a nearly identical number and arrangement of amino acid sequence motifs with human LRP, and several exons of the C. elegans LRP gene correspond to exons of related parts of the human LDL receptor gene. The existence of an apparent homolog of LRP in C. elegans offers the possibility of genetic analysis of the in vivo roles of LRP and of the relationship between protein structure and function in a simple model organism.
Optimal via minimisation by selection of layer assignment and routing ordering in a bubble-sorting-based non-Manhattan channel (2003)

It is well known that a non-Manhattan channel router always uses no more tracks than a Manhattan router in a channel. For a bubble-sorting-based non-Manhattan channel, all of the nets can be routed by k bubble-sorting swap passes in an optimal bubble-sorting solution, and these k swap passes can be further mapped onto k 1-track-routing processes in a two-layer routing model. However, these proposed bubble-sorting-based non-Manhattan routers do not consider an optimal routing ordering for the physical mapping of the k swap passes, and redundant vias are yielded in a random routing ordering. Based on the result of k swap passes in an optimal bubble-sorting solution: (i) optimal via minimisation by the selection of layer assignment and routing ordering in a bubble-sorting-based non-Manhattan channel is proposed; and (ii) the time complexity of this proposed algorithm is proven to be in O(k2) time, where k is the number of swap passes in an optimal bubble-sorting solution.
A Real-Time Route Diversion Management System (2007)

We present our work on the Real-Time Route Diversion System RTRDS, a module developed for the State of Florida's SunGuide Automated Transportation Management System <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ATMS</i> . Our RTRDS is an extensible, adaptor-based framework designed to create optimal route diversions based upon available real-time and historical traffic information, and disseminate these plans in real time. Given the need for a route diversion, operators can choose to have the system generate a new route diversion, or select from an archive of historical route diversions. The user interface permits operators to modify generated and historical route diversion plans on-the-fly and then implement them with existing hardware (dynamic message signs, etc.). Furthermore, due to the tight integration with Dynasmart-P, operators can save the current route diversion plan and traffic conditions to files that can be used for later performance analysis.
Continuous kinetics for thermal degradation of polymer in solution (1995)

Abstract Continuous kinetics of thermal degradation of poly (styrene‐allyl alcohol) (PSA) in solution are explored theoretically and experimentally. Thermal degradation experiments for PSA of number‐average molecular weight 1,640 in t‐butanol solution were conducted in a steady‐state flow reactor at 6.8 MPa and 403–473 K. The molecular‐weight distributions (MWDs) of the original polymer and its reaction products were measured as a function of residence time by gel permeation chromatography The MWD of the initial PSA is described by a gamma distribution function. Experimental data indicated that the polymer cracks to specific, low‐molecular‐weight (MW) products and degrades by random chain scission. Results are interpreted by a mathematical model based on the continuous kinetics for specific and random degradation processes. Rate coefficients are determined separately from the dynamic data of the MW moments for the specific products and the MWDs for the reacting polymer. Activation energies obtained are 5.9 – 7.4 kcal/mol for specific degradation processes and 35 kcal/mol for the random degradation process. The detailed MWDs are related to conventional lumped (numberaverage molecular‐weight) data.
Immune stimulatory and anti-tumour properties of haemin (1993)

IL-2 induces tumour regression in some patients with metastatic disease, but the dose of IL-2 is limited by severe toxicity. Agents that increase the expression of IL-2 receptors in the effector cells could be used to improve the effectiveness of IL-2 in mediating its anti-tumour effect. We have reported that haemin increased the expression of IL-2 receptors in human peripheral blood mononuclear cells (PBMC) and synergized with IL-2 in the induction of mitogenicity, cytotoxicity and cytokine production. We now report on haemin-induced immune stimulation and tumour regression in mice. Haemin-induced mitogenicity in mouse splenocytes was potentiated up to two-fold by IL-2. The combination of haemin and IL-2 was also effective in inducing cytotoxicity for natural killer (NK)-resistant target cells. Maximal induction of cytotoxicity was attained at an optimal concentration of haemin of 10 microM. Higher concentrations were less effective. Splenocytes isolated from mice that had been treated in vivo with haemin and IL-2 incorporated twice the amount of 3H-thymidine compared with splenocytes from mice treated with either haemin or IL-2 alone. Cytotoxicity of splenocytes for NK-resistant target cells was not increased following in vivo administration of haemin and IL-2 when fresh splenocytes were tested. Cytotoxicity was enhanced, however, up to five-fold following 48 h in vitro incubation with IL-2. Administration of haemin and IL-2 resulted in a significant decrease (40%) of established hepatic metastases in mice. Either IL-2 or haemin alone at the dose used were ineffective. The anti-tumour effect of haemin and IL-2 was enhanced (63% decrease in metastases) by administration of the thiol compound, N-acetylcysteine. Since haemin can safely be administered to patients, it may represent a new class of biologic response modifiers that could enhance IL-2-mediated anti-tumour effects.
Object identification in the lego kernel (1993)

Abstract In a message‐based operating system, the kernel is responsible for forwarding messages to destination objects using a destination identifier. Part of the kernel overhead in processing the message involves mapping the identifier into a network address. This paper describes how the choice of identifier structure has simplified the techniques used by the Lego kernel when handling messages, notably: minimizing the overheads associated with address mapping, eliminating the reception of unwanted network packets, while permitting both individual (unicast) and group (multicast) communications.
Presentation of a Structurally Diverse and Commercially Available Drug Data Set for Correlation and Benchmarking Studies (2006)

A multivariate analysis of drugs on the Swedish market was the basis for the selection of a small, physicochemically diverse set of 24 drug compounds. Factors such as structural diversity, commercial availability, price, and a suitable analytical technique for quantification were considered in the selection. Lipophilicity, pKa, solubility, and permeability across human Caco-2 cell monolayers were measured for the compiled data set. The results show that, by use of a physicochemically diverse data set, experimental responses over a wide range were obtained. The paper also shows how experimental difficulties due to the diversity of the data set can be overcome. We anticipate that this data set can serve as a benchmark set for validation of new experimental techniques or in silico models. It can also be used as a diverse starting data set for the development of new computational models.