gebhart/patrepeval huggingface dataset:
Genital herpes infection: a review (1997)

Genital herpes infection is life-long and may result in painful and recurrent genital lesions, systemic complications, serious psychosocial morbidity, and rare but serious outcomes in neonates born to infected women, including permanent neurological handicap and death. Herpes simplex virus (HSV)-2 is the principal cause, with an increasing proportion of first-episode disease caused by HSV-1. Genital HSV transmission is usually due to asymptomatic viral shedding by people who are unaware that they are infected and clinical screening fails to detect most infections. Type-specific serological assays can distinguish the two viral subtypes, but these are expensive and currently restricted to a few research settings. Most infections are asymptomatic, or cause a mild illness which does not lead to health service attendance; but the limited evidence suggests a rise in disease incidence, perhaps related to a fall in HSV-1 age-specific prevalences. The prevalences of HSV genital infections increase with age and numbers of sexual partners, with higher rates in specific ethnic and low socioeconomic groups. However, infection is not restricted to high-risk populations. Antiviral agents, such as acyclovir, can reduce disease severity, prevent recurrences and shorten periods of viral shedding, but currently there are no effective population control measures. This may change with the advent of HSV vaccines, if their safety and long-term efficacy are confirmed. Possible applications for vaccines may include the suppression of disease and recurrences in patients with genital infections (immunotherapy), the prevention of viral transmission to their seronegative partners, and immunoprevention through vaccinating the latter. Economic evaluations of existing and potential control strategies, age-specific population HSV-1 and 2 seroprevalence studies for targeting future interventions, and cohort studies to elucidate the natural history of HSV-2 infections are needed.
Müller, Adam Heinrich (1779–1829) (1987)

Born in Berlin, Müller studied in Göttingen and became a private tutor and scholar. In 1811 he had to leave Berlin because of his opposition to the reforms of Hardenberg, and later served the Austrian foreign minister Metternich in various – partly conspiratorial – positions, for which he was created knight of Nitterdorf in 1826. An ardent catholic – he had converted in 1805 – Müller opposed the ideals of the Enlightenment, and rejected liberalism, rationalism, individualism and materialism. He was a bitter enemy of the French Revolution and one of the intellectual voices of the post-Napoleonic restoration.
Role of Mitogen-Activated Protein (MAP) Kinases in Cardiovascular Diseases (2006)

Over the last decade important advances have been made in our understanding of the molecular events underlying cellular responses to extracellular signals. Increased understanding of signal transduction mechanisms and gene regulation involved in cardiovascular diseases has created opportunities for the discovery of novel therapeutic compounds useful for the treatment of cardiovascular disorders. One of the best-studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway, which plays a crucial role in many aspects of cardiovascular responses. Here, our current understanding of the MAP kinase pathway is reviewed, as well as recent advances in the design of novel agents that are able to modulate the activity of these signaling cascades.
The cross charge-control flip-flop: a low-power and high-speed flip-flop suitable for mobile application SoCs (2005)

This paper presents a low power and high-speed flip-flop named cross charge-control flip-flop (XCFF). It has two dynamic nodes driving output transistors separately. The minimum power-delay product of the XCFF is 48% smaller than that of CMOS flip-flop and 20% smaller than that of the semi-dynamic flip-flop (SDFF). Applying it to a 125-MHz microprocessor core, we can achieve 10% power reduction without any speed or area penalty.
Film actinometer for measurement of solar ultraviolet radiation intensities in urban atmospheres (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFilm actinometer for measurement of solar ultraviolet radiation intensities in urban atmospheresJames N. Pitts, Jr., Gawin W. Cowell, and David R. BurleyCite this: Environ. Sci. Technol. 1968, 2, 6, 435–437Publication Date (Print):June 1, 1968Publication History Published online1 May 2002Published inissue 1 June 1968https://pubs.acs.org/doi/10.1021/es60018a006https://doi.org/10.1021/es60018a006research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Real-Time Garbage Collection Mechanism for Flash-Memory Stroage Systems in Embedded Systems (2002)

Flash memory technology is becoming critical in building embedded systems applications because of its shock-resistant, power economic, and non-volatile nature. Because flash memory is a write-once and bulkerase medium, a translation layer and a garbage collection mechanism is needed to provide applications a transparent storage service. In this paper, we propose a real-time garbage collection mechanism, which provides a deterministic performance, for hard real-time systems. A wear-levelling method, which serves as a non-real-time service, is presented to resolve the endurance issue of flash memory. The capability of the proposed mechanism is demonstrated by a series of experiments over our system prototype.
Minimizing server throughput for low-delay live streaming in content delivery networks (2012)

Large-scale live streaming systems can experience bottlenecks within the infrastructure of the underlying Content Delivery Network. In particular, the "equipment bottleneck" occurs when the fan-out of a machine does not enable the concurrent transmission of a stream to multiple other equipments. In this paper, we aim to deliver a live stream to a set of destination nodes with minimum throughput at the source and limited increase of the streaming delay. We leverage on rateless codes and cooperation among destination nodes. With rateless codes, a node is able to decode a video block of k information symbols after receiving slightly more than k encoded symbols. To deliver the encoded symbols, we use multiple trees where inner nodes forward all received symbols. Our goal is to build a diffusion forest that minimizes the transmission rate at the source while guaranteeing on-time delivery and reliability at the nodes. When the network is assumed to be lossless and the constraint on delivery delay is relaxed, we give an algorithm that computes a diffusion forest resulting in the minimum source transmission rate. We also propose an effective heuristic algorithm for the general case where packet loss occurs and the delivery delay is bounded. Simulation results for realistic settings show that with our solution the source requires only slightly more than the video bit rate to reliably feed all nodes.
Low loss micromachined filters for millimeter-wave telecommunication systems (2002)

This paper describes the design and the realization of two membrane supported microstrip millimeter-wave planar bandpass filters. Both filters exhibit transmission zeros and a 2.3 dB port-to-port insertion loss for the 37 GHz 3.5% bandwidth 2-pole filter and a 1.5 dB insertion loss for a 60 GHz 8% bandwidth 4-pole filter. The use of membrane technology allows a significant reduction of insertion loss, combined with a reproducible, low cost fabrication process.
Pharmacokinetics of emtricitabine, didanosine and efavirenz administered once‐daily for the treatment of HIV‐infected adults (pharmacokinetic substudy of the ANRS 091 trial)<sup>*</sup> (2004)

The simultaneous administration of FTC, ddI and EFV did not affect the PK parameters of FTC when compared to historical controls. EFV Cmax and Cmin were lower than expected, but the data may have been slightly underestimated in this study. High ddI AUC and Cmax were measured in these patients, and further studies are warranted to confirm this finding.
An analysis and comparison of keyword recommendation methods for scientific data (2020)

Abstract To classify and search various kinds of scientific data, it is useful to annotate those data with keywords from a controlled vocabulary. Data providers, such as researchers, annotate their own data with keywords from the provided vocabulary. However, for the selection of suitable keywords, extensive knowledge of both the research domain and the controlled vocabulary is required. Therefore, the annotation of scientific data with keywords from a controlled vocabulary is a time-consuming task for data providers. In this paper, we discuss methods for recommending relevant keywords from a controlled vocabulary for the annotation of scientific data through their metadata. Many previous studies have proposed approaches based on keywords in similar existing metadata; we call this the indirect method . However, when the quality of the existing metadata set is insufficient, the indirect method tends to be ineffective. Because the controlled vocabularies for scientific data usually provide definition sentences for each keyword, it is also possible to recommend keywords based on the target metadata and the keyword definitions; we call this the direct method . The direct method does not utilize the existing metadata set and therefore is independent of its quality. Also, for the evaluation of keyword recommendation methods, we propose evaluation metrics based on a hierarchical vocabulary structure, which is a distinctive feature of most controlled vocabularies. Using our proposed evaluation metrics, we can evaluate keyword recommendation methods with an emphasis on keywords that are more difficult for data providers to select. In experiments using real earth science datasets, we compare the direct and indirect methods to verify their effectiveness, and observe how the indirect method depends on the quality of the existing metadata set. The results show the importance of metadata quality in recommending keywords.
Synthetic and Natural Coumarins as Cytotoxic Agents (2005)

Coumarins, an old class of compounds, are naturally occurring benzopyrene derivatives. A lot of coumarins have been identified from natural sources, especially green plants. The pharmacological and biochemical properties and therapeutic applications of simple coumarins depend upon the pattern of substitution. Coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. Among these properties, their cytotoxic effects were most extensively examined. In this review, their broad range of effects on the tumors as shown by various in vitro and in vivo experiments and clinical studies are discussed. Hence, these cytotoxic coumarins represent an exploitable source of new anticancer agents, which might also help addressing side-toxicity and resistance phenomena. These natural compounds have served as valuable leads for further design and synthesis of more active analogues. In this review, plant derived coumarins and their synthetic analogues were systematically evaluated based on their plant origin, structure-activity relationship and anticancer efficacy. Owing the their diverse effects and inconclusive results from different in vitro studies, the mechanism of their action is not yet fully understood and correlation of effects with chemical structures is not conclusive at the moment. It is the objective of this review to summarize experimental data for different coumarins, used as cytotoxic agents, because promising data have been reported for a series of these agents. Yet, the results from different coumarins with various tumor lines are contradictory in part. We therefore conclude that there is still a long way to go until we know which cytotoxic agent will clinically be suitable for what tumor entity for treatment. Their ability to bind metal ions represents an additional means of modulating their pharmacological responses.
Isolation, sequence, and characterization of the Cercospora nicotianae phytoene dehydrogenase gene (1994)

We have cloned and sequenced the Cercospora nicotianae gene for the carotenoid biosynthetic enzyme phytoene dehydrogenase. Analysis of the derived amino acid sequence revealed it has greater than 50% identity with its counterpart in Neurospora crassa and approximately 30% identity with prokaryotic phytoene dehydrogenases and is related, but more distantly, to phytoene dehydrogenases from plants and cyanobacteria. Our analysis confirms that phytoene dehydrogenase proteins fall into two groups: those from plants and cyanobacteria and those from eukaryotic and noncyanobacter prokaryotic microbes. Southern analysis indicated that the C. nicotianae phytoene dehydrogenase gene is present in a single copy. Extraction of beta-carotene, the sole carotenoid accumulated by C. nicotianae, showed that both light- and dark-grown cultures synthesize carotenoids, but higher levels accumulate in the light. Northern (RNA) analysis of poly(A)+ RNA, however, showed no differential accumulation of phytoene dehydrogenase mRNA between light- and dark-grown fungal cultures.
Continuous in vivo blood pressure measurements using a fully implantable wireless SAW sensor (2013)

In this paper, the development of a fully implantable wireless sensor able to provide continuous real-time accurate pressure measurements is presented. Surface Acoustic Wave (SAW) technology was used to deposit resonators on crystalline quartz wafers; the wafers were then assembled to produce a pressure sensitive device. Excitation and reading via a miniature antenna attached to the pressure sensor enables continuous external interrogation. The main advantages of such a configuration are the long term stability of quartz and the low power necessary for the interrogation, which allows 24/7 interrogation by means of a hand-held, battery powered device. Such data are of vital importance to clinicians monitoring and treating the effects of hypertension and heart failure. A prototype was designed and tested using both a bio-phantom test rig and an animal model. The pressure traces for both compare very well with a commercially available catheter tip pressure transducer. The work presented in this paper is the first known wireless pressure data from the left ventricle of the heart of a living swine.
Monitoring and Control (2010)

This chapter contains sections titled: Process Monitoring Bath Constituent Concentration Monitoring and Replenishment Monitoring and Control of Finished Product Summary References
High-stability Er/sup 3+/-doped superfluorescent fiber sources (1995)

Data are presented on Er/sup 3+/-doped superfluorescent fiber sources showing the dependence of output characteristics on pump wavelength and power, fiber length, fiber temperature, and feedback. In particular, the broadband operation and mean wavelength stability required for fiber optic gyroscope applications are evaluated. Substantial improvements in the mean wavelength stability with pump power have been achieved by optimizing the fiber length. An all-fiber superfluorescent fiber source utilizing a fiber-pigtailed 980-nm diode pump laser is demonstrated, with a 1-h mean wavelength stability better than 0.9 ppm RMS and /spl les/8 ppm drift over 20 h. The intrinsic mean wavelength variation versus fiber temperature is measured, with values of 4.8 and 3.0 ppm//spl deg/PC obtained for fiber lengths of 23 and 78 m, respectively.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Interferon Induction by Viruses. XVII. Non-temperature-sensitive Mutations Regulate Interferon Induction by Vesicular Stomatitis Virus (1989)

Wild-type (wt) strains of vesicular stomatitis virus (VSV) strain Indiana are poor to non-inducers of interferon (IFN) which express IFN induction-suppressing activity. At non-permissive temperatures, temperature-sensitive (ts) mutants of this virus are either like their wt parents, or they are good to excellent inducers of IFN. IFN inducibility and IFN induction-suppressing activity are mutually exclusive phenotypes in VSV-Indiana. With one exception, all Orsay ts mutants derived by A. Flamand (CNRS, Gif-sur-Yvette, France), representing the five complementation groups, were poor to non-inducers of IFN and were also capable of suppressing IFN induction by other viruses. In contrast, all Glasgow ts mutants derived by C. R. Pringle (University of Warwick, Coventry, U.K.) were excellent inducers of IFN. We demonstrate that this difference in acquisition of IFN inducibility relates primarily to the origin of the mutations; spontaneous for Orsay, and mutagen-derived for Glasgow. Tests with newly generated spontaneous and mutagen-derived mutants, and temperature-stable revertants of IFN-inducing ts mutants indicate that IFN inducibility results from non-ts, multiple mutations rarely acquired spontaneously, but generated frequently upon mutagenesis with 5-fluorouracil. The capacity of VSV-Indiana to induce IFN is considered intrinsic to the virus, but is only manifested when the dominant IFN induction-suppressing phenotype is lost through mutagenesis. Thus, non-ts mutations appear to regulate the expression of the IFN induction-suppressing phenotype, and hence the IFN inducibility of VSV-Indiana.
Measurement of Instantaneous Blood Flow Velocity and Pressure in Conscious Man with a Catheter-Tip Velocity Probe (1969)

Twenty-three patients were investigated during diagnostic right and left cardiac catheterization with an electromagnetic catheter-tip velocity probe. The catheter contained a pressure lumen for simultaneous measurements of intravascular pressure. Average peak and mean blood velocities were 66 and 11 cm/sec in the ascending aorta, 57 and 10 cm/sec in the pulmonary artery, 28 and 12 cm/sec in the superior vena cava, and 26 and 13 cm/sec in the inferior vena cava. The velocity pattern in the ascending aorta was similar to that obtained by other methods. Positioning of the catheter in the ascending aorta required care; in one patient with aortic stenosis the recorded blood velocity pattern was unsatisfactory. In the pulmonary artery flicking of the catheter often produced artifacts in the records. The effect of deep respiration on blood velocity in the ascending aorta and pulmonary artery was studied. In the ascending aorta the highest velocities and stroke volumes were achieved during late expiration while in the pulmonary artery blood velocity and stroke volume were greatest in inspiration. In nine patients the cardiac outputs calculated from the product of mean velocity and radiologically measured cross-sectional area of the ascending aorta or pulmonary artery were compared with cardiac outputs determined by the indicator-dilution method; the correlation coefficient was 0.73. There were no complications, and the probe proved reliable.
Brg1 Is Required for Cdx2-Mediated Repression of Oct4 Expression in Mouse Blastocysts (2010)

During blastocyst formation the segregation of the inner cell mass (ICM) and trophectoderm is governed by the mutually antagonistic effects of the transcription factors Oct4 and Cdx2. Evidence indicates that suppression of Oct4 expression in the trophectoderm is mediated by Cdx2. Nonetheless, the underlying epigenetic modifiers required for Cdx2-dependent repression of Oct4 are largely unknown. Here we show that the chromatin remodeling protein Brg1 is required for Cdx2-mediated repression of Oct4 expression in mouse blastocysts. By employing a combination of RNA interference (RNAi) and gene expression analysis we found that both Brg1 Knockdown (KD) and Cdx2 KD blastocysts exhibit widespread expression of Oct4 in the trophectoderm. Interestingly, in Brg1 KD blastocysts and Cdx2 KD blastocysts, the expression of Cdx2 and Brg1 is unchanged, respectively. To address whether Brg1 cooperates with Cdx2 to repress Oct4 transcription in the developing trophectoderm, we utilized preimplantation embryos, trophoblast stem (TS) cells and Cdx2-inducible embryonic stem (ES) cells as model systems. We found that: (1) combined knockdown (KD) of Brg1 and Cdx2 levels in blastocysts resulted in increased levels of Oct4 transcripts compared to KD of Brg1 or Cdx2 alone, (2) endogenous Brg1 co-immunoprecipitated with Cdx2 in TS cell extracts, (3) in blastocysts Brg1 and Cdx2 co-localize in trophectoderm nuclei and (4) in Cdx2-induced ES cells Brg1 and Cdx2 are recruited to the Oct4 promoter. Lastly, to determine how Brg1 may induce epigenetic silencing of the Oct4 gene, we evaluated CpG methylation at the Oct4 promoter in the trophectoderm of Brg1 KD blastocysts. This analysis revealed that Brg1-dependent repression of Oct4 expression is independent of DNA methylation at the blastocyst stage. In toto, these results demonstrate that Brg1 cooperates with Cdx2 to repress Oct4 expression in the developing trophectoderm to ensure normal development.
El capital social y la flexibilización del derecho (2017)

El siguiente trabajo analiza el objetivo de la Ley 14/2013, de 27 de septiembre, de apoyo a los emprendedores y su internacionalización, sobre todo el papel a desarrollar por la sociedad limitada de formación sucesiva, así como la figura garantista del capital social tanto en dicha ley como en el derecho de sociedades español. A continuación, expondremos cómo el derecho societario estadounidense es capaz de conjugar flexibilidad y protección de terceros sin la figura del capital social; así como la tendencia que han experimentado tanto el derecho societario europeo como español durante las últimas décadas. Nos detendremos con especial atención en la sociedad por acciones simplificada francesa, en tanto en cuanto supone una regulación flexible del derecho de sociedades dentro de un ordenamiento jurídico con muchas similitudes al ordenamiento jurídico español. Para terminar, en nuestras conclusiones expondremos si la Ley 14/2013 y la sociedad limitada han resultado ser un éxito, así como la dirección que consideramos debe tomar el derecho de sociedades español.