gebhart/patrepeval huggingface dataset:
The Application of Heat Pipe Heat Sink for High Power LED Lamps (2014)

LED has been regarded as the next generation lighting source. As for high power LED lamps, heat accumulation will cause a series of problems. Therefore, thermal management is very important for designing a high power LED lamp. Three types of heat sinks are designed by using the finite element analysis (FEA) method for an 180W high power LED lamp. Then the optimized heat sinks are developed and experiments are performed to demonstrate the simulated results. At the same time, the thermal performances with different working angles are investigated experimentally. The heat sink with heat pipe has a better heat dissipation performance than the conventional heat sink under the same input power. The working angles of the lamps greatly influence the thermal performance of each heat sink. For the same heat sink, the temperature varies with different install directions and working angles. Finally, the heat sink with the best thermal performance is recommended. The results have practical significance in designing high power LED lamps.
Primary Prevention of Coronary Arterial Thrombosis with the Factor Xa Inhibitor rTAP in a Canine Electrolytic Injury Model (1995)

The antithrombotic efficacies of the coagulation factor Xa inhibitor recombinant tick anticoagulant peptide (rTAP) and heparin were compared in a canine model of left circumflex (LCX) coronary artery electrolytic lesion. Intravenous infusions of saline (controls), rTAP (50 micrograms/kg/min continuous infusion) or heparin (200 U/kg bolus followed by 2 U/kg/min continuous infusion) were started 60 min prior to the initiation of LCX coronary artery electrolytic injury (150 microA continuous anodal current). All 6/6 saline-treated control animals developed occlusive thrombi at 49.8 +/- 13.6 min after the initiation of vessel injury, and possessed a residual thrombus mass of 20.7 +/- 3.3 mg. In the rTAP treatment group, 4/6 preparations developed occlusive thrombi, but with times to thrombosis delayed significantly compared to both the saline control as well as to the heparin treatment group (202.7 +/- 28.9 min; p < 0.01 to both saline and heparin groups). The remaining 2 rTAP-treated preparations remained patent despite the continued electrical stimulation of the coronary vessel for 5 h. Residual thrombus mass in the rTAP treatment group was reduced markedly compared to the saline control group (4.4 +/- 1.0 mg; p < 0.01). Heparin infusion resulted in a modest but statistically insignificant delay in occlusive LCX coronary artery thrombosis compared to saline controls, with all 6/6 heparin-treated preparations occluding at 79.7 +/- 16.5 min after the initiation of vessel injury. Residual thrombus mass in heparin-treated animals, however, was reduced compared to saline controls (9.4 +/- 1.4 mg; p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Secure Enclave for TLS Web Server on Untrusted Environment (2017)

Web servers use SSL/TLS to establish secure communication between clients and servers. The mechanism of SSL/TLS relies on a key pair to validate the server and to protect the confidentiality of the data. However, many websites are running on third-party servers or on cloud environments where website owners have no control over the physical servers or the software including the operating systems but still need to trust and store the private key on the servers. While it is common to store the encrypted key on the disk, the web server still need a decrypted key inside the memory during the operation. Thus, an adversary could obtain the private key residing on the web server's memory. In this paper, we propose a secure enclave for a web server running the high privilege code that handles the secret keys inside an encrypted memory area by utilizing Intel Software Guard Extension (SGX) whereas other components of the web server outside the trusted computing base are left intact. The experimental results show 19% to 38% implementation overhead depending on which cipher suite is used and how a session key is handled.
High-Density Lipoprotein-like Magnetic Nanostructures (HDL-MNS): Theranostic Agents for Cardiovascular Disease (2017)

We report the development of potential theranostic agents for cardiovascular disease that are based on high-density lipoprotein-like magnetic nanostructures (HDL-MNS). The HDL-MNS offer prospects for diagnosis via noninvasive magnetic resonance imaging for anatomic detection and also serve as effective cholesterol efflux agents to address atherosclerotic vascular lesions. The HDL-MNS are synthesized by adding phospholipids and the HDL-defining apolipoprotein A1 to the surface of magnetic nanostructures (MNS) to mimic some aspects of natural HDL particles. From a diagnostic perspective, HDL-MNS show a 5 times higher contrast (r2 relaxivity up to 383 mM–1 s–1) in magnetic resonance imaging (MRI) than commercially available T2 MRI contrast agents (e.g., Ferumoxytol). Internalization of HDL-MNS by macrophage cells was confirmed by transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), inductive-coupled plasma mass spectrometry (ICP-MS), and successfully imaged via MRI. Also, the HDL-MNS particles show capacity to induce cholesterol efflux (∼4.8%) from macrophage cells comparable to natural HDL (∼4.7%), providing a pathway to prevent and treat cardiovascular disease via reverse cholesterol transport. The ability to image macrophage cells that have internalized HDL-MNS along with the cholesterol efflux capacity demonstrates the potential of the HDL-MNS particles as theranostic agents.
Surface-Modified Membrane as A Separator for Lithium-Ion Polymer Battery (2010)

This paper describes the fabrication of novel modified polyethylene (PE) membranes using plasma technology to create high-performance and cost-effective separator membranes for practical applications in lithium-ion polymer batteries. The modified PE membrane via plasma modification process plays a critical role in improving wettability and electrolyte retention, interfacial adhesion between separators and electrodes, and cycle performance of lithium-ion polymer batteries. This paper suggests that the performance of lithium-ion polymer batteries can be greatly enhanced by the plasma modification of commercial separators with proper functional materials for targeted application.
Synchronized Phasor and Frequency Measurement Under Transient Conditions (2008)

Synchronized phasor measurements are becoming an important element of wide area measurement systems used in advanced power system monitoring, protection, and control applications. The recently issued revised standard C37.118 for synchrophasors has facilitated interoperability of phasor measurement units (PMUs) from different manufacturers. This standard defines performance for compliance when the input signals are in steady state. The performance of PMUs under transient conditions is not considered by the standard at this time, although clearly PMUs will be subjected to inputs under transient conditions. This paper is an attempt to provide the authors' views on how one may approach the question of standardizing PMU response under transient conditions.
Near‐field optical imaging of abasic sites on a single DNA molecule (2003)

Scanning near-field optical microscopy (SNOM) imaging was performed to allow for the direct visualization of damaged sites on individual DNA molecules to a scale of a few tens of nanometers. Fluorescence in situ hybridization on extended DNA molecules was modified to detect a single abasic site. Abasic sites were specifically labelled with a biotinlylated aldehyde-reactive probe and fluorochrome-conjugated streptavidin. By optimizing the performance of the SNOM technique, we could obtain high contrast near-field optical images that enabled high-resolution near-field fluorescence imaging using optical fiber probes with small aperture sizes. High-resolution near-field fluorescence imaging demonstrated that two abasic sites within a distance of 120 nm are clearly obtainable, something which is not possible using conventional fluorescence in situ hybridization combined with far-field fluorescence microscopy.
Structure determination of two conotoxins from Conus textile by a combination of matrix‐assisted laser desorption/ionization time‐of‐flight and electrospray ionization mass spectrometry and biochemical methods (2000)

Two highly modified conotoxins from the mollusc Conus textile, ϵ-TxIX and Gla(1)-TxVI, were characterized by matrix-assisted laser desorption/ionization and electrospray mass spectrometry and also by electrospray ionization tandem and triple mass spectrometry in combination with enzymatic cleavage and chemical modification reactions. The mass spectrometric studies allowed the confirmation of the sequence determined by Edman degradation and assignment of unidentified amino acid residues, among which bromotryptophan residues and an O-glycosylated threonine residue were observed. Methyl esterification was found necessary for the site-specific assignment of the Gla residues in the peptides. Copyright © 2000 John Wiley & Sons, Ltd.
Spectroscopic Studies of Inhibited Alcohol Dehydrogenase from<i>Thermoanaerobacter</i><i>brockii</i>: Proposed Structure for the Catalytic Intermediate State (2000)

Thermoanaerobacter brockii alcohol dehydrogenase (TbADH) catalyzes the reversible oxidation of secondary alcohols to the corresponding ketones using NADP(+) as the cofactor. The active site of the enzyme contains a zinc ion that is tetrahedrally coordinated by four protein residues. The enzymatic reaction leads to the formation of a ternary enzyme-cofactor-substrate complex; and catalytic hydride ion transfer is believed to take place directly between the substrate and cofactor at the ternary complex. Although crystallographic data of TbADH and other alcohol dehydrogenases as well as their complexes are available, their mode of action remains to be determined. It is firmly established that the zinc ion is essential for catalysis. However, there is no clear agreement about the coordination environment of the metal ion and the competent reaction intermediates during catalysis. We used a combination of X-ray absorption, circular dichroism (CD), and fluorescence spectroscopy, together with structural analysis and modeling studies, to investigate the ternary complexes of TbADH that are bound to a transition-state analogue inhibitor. Our structural and spectroscopic studies indicated that the coordination sphere of the catalytic zinc site in TbADH undergoes conformational changes when it binds the inhibitor and forms a pentacoordinated complex at the zinc ion. These studies provide the first active site structure of bacterial ADH bound to a substrate analogue. Here, we suggest the active site structure of the central intermediate complex and, more specifically, propose the substrate-binding site in TbADH.
Autoantibodies against the signal peptide domain of MUC1 in patients with multiple myeloma: Implications for disease diagnosis and prognosis (2012)

Naturally generated autoantibodies to tumor-associated antigens such as MUC1 can assist in cancer diagnosis and prognosis. While previous studies have concentrated on the tandem repeat array domain of MUC1, here we focused on MUC1's signal peptide domain. We used ELISA assays with MUC1-specific epitopes and antibodies to quantify soluble MUC1 antigen and anti-MUC1 autoantibodies against the tandem repeat array and signal peptide domains in 15 naïve donors and 27 multiple myeloma cancer patients. We showed a significant increase in up to 24-fold (P<0.004) only in the levels of anti-MUC1 signal peptide autoantibodies in the sera of multiple myeloma patients vs. naïve donors. This increase stemmed chiefly from the preferred immunogenicity of the signal peptide. Moreover, a significant positive correlation (R(2)=0.5361, P<0.048, Pearson correlation) was shown between the levels of soluble MUC1 and anti-MUC1 signal peptide autoantibodies in multiple myeloma patients with progressive disease while under therapy. This is an initial report on the existence of autoantibodies to a signal peptide domain in general and to the MUC1 signal peptide domain in particular in cancer patients. The autoantibodies had MUC1 rather than signal peptide specificity. The specific nature of the antigen leading to generation of these autoantibodies is still unclear because it is unlikely that the target antigen is a major histo-compatibility complex-peptide complex and we could not trace soluble MUC1 signal peptide fragments in naïve donors and multiple myeloma patients. Further validation of these findings may improve diagnostic and prognostic capabilities for MUC1-positive multiple myeloma patients and potentially, patients with other MUC1-positive cancers, as well.
Hierarchically structured re-entrant microstructures for superhydrophobic surfaces with extremely low hysteresis (2014)

This paper reports a new type of hierarchically structured surface consisting of re-entrant silicon micropillars with silicon nanowires atop for superhydrophobic surface with extremely low hysteresis. Re-entrant microstructures were fabricated on a silicon substrate through a customized one-mask microfabrication process while silicon nanopillars were created on the entire surface of microstructures, including sidewalls, by a metal-assisted-chemical etching process. The strategy of constructing hierarchical surfaces aims to reduce the actual contact area between liquid and top part of solid surface, thereby increasing the contact angle and reducing the sliding angle. The strategy of using re-entrant profile of the microstructure aims to prevent a liquid droplet from falling into cavities of roughened structures and decrease the actual contact area between the liquid droplet and sidewalls of solid structures, therefore reducing adhesion forces acting on the liquid droplet. Our measurement shows that the surface incorporating both hierarchical and re-entrant strategies exhibits a sliding angle as low as 0.5°, much lower than sliding angles of surfaces only incorporating either one of the strategies.
Dummy Cell Would Improve Performance Of Fuel-Cell Stack (1993)

Interposition of dummy cell between stack of alkaline fuel cells and accessory section of fuel-cell powerplant proposed to overcome operational deficiencies plaguing end-most active cell. Cell in combination with additional hydrogen/coolant separator plate keeps end cell warmer and drier. End cell 96th in stack of fuel cells.
Die systematische Stellung der Gattung Amixia REUTER, 1883 (Hem. Het. Miridae) (1957)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Protein and DNA elements involved in transactivation of the promoter of the bovine herpesvirus (BHV) 1 IE-1 transcription unit by the BHV alpha gene trans-inducing factor (1994)

In herpes simplex virus (HSV)-infected cells, the transcription of immediate-early (alpha) genes is regulated by a virion component, the alpha gene trans-inducing factor (alpha TIF). This protein forms a complex with cellular factors and TAATGARAT motifs present in one or more copies in the promoters of all alpha genes. We have characterized the bovine herpesvirus 1 (BHV-1) homolog of this protein. Like its HSV counterpart, the BHV alpha TIF was synthesized in the later stages of infection and could be demonstrated to be a component of purified virions. In transient expression assays, BHV alpha TIF was a strong transactivator and stimulated the activity of IE-1, the major BHV-1 alpha gene promoter, with an efficiency comparable to that of HSV alpha TIF. This stimulation was largely dependent on a TAATGAGCT sequence present in a single copy in IE-1, and BHV alpha TIF, in conjunction with cellular factors, formed a complex with oligonucleotides containing this sequence. Despite these similarities between the two alpha TIFs, our preliminary observations suggest that the proteins may activate transcription by different mechanisms. Although BHV alpha TIF strongly transactivated IE-1, it differed from its HSV counterpart in that the carboxyl terminus of BHV alpha TIF, when fused to the DNA-binding domain of GAL4, was a relatively poor stimulator of a promoter containing GAL4-binding sites. Also unlike HSV alpha TIF, removal of the carboxyl terminus of BHV alpha TIF reduced but did not eliminate the ability of the protein to transactivate IE-1. These results are discussed in view of the structural similarities and differences among the alpha TIFs of alphaherpes-viruses.
Cystinotic fibroblasts accumulate cystine from intracellular protein degradation. (1977)

Fibroblasts derived from patients with cystinosis, an autosomal recessive condition, accumulate the disulfide amino acid cystine within lysosomes. The metabolic defect leading to the cystine accumulation and the source from which the cystine is derived are unknown. In this report we present data showing that cystine in these cells accumulates from the degradation of endogenous protein. This conclusion is based upon: (i) no demonstrable synthesis of cystine from serine; (ii) no difference in cystine reaccumulation between glutathione-depleted and non-glutathione-depleted cystinotic cells; (iii) recovery of labeled cystine only when the protein pool is labeled; (iv) reversible inhibition of cystine reaccumulation by known inhibitors of lysosomal protein degradation (chloroquine and NH4Cl).
Frequenzsteuerung von Schrittmachern durch Bluttemperatur (1978)

Die bisher gebräuchlichen Schrittmacher (SM) können nicht zur Steigerung der HMV durch Erhöhung der Stimulationsfrequenz beitragen. Während einer diagnostischen EK-Untersuchung wurde bei 30 Patienten mit normaler Sinusknotenfunktion die zentrale Bluttemperatur (ZBT) mit einem Edwards TCO Computer No. 9520 in Ruhe und in jeder Minute der Belastung gemessen. Die ZBT erhöht sich nach dem Grad und der Dauer der Belastung.
Retrieval of complex field using nonlinear optimization (2005)

Intensity measurements in two or more planes are used by a nonlinear optimization algorithm to retrieve the phase. The complex field (amplitude and phase) in the pupil or elsewhere is then computed by simple propagation.
Eine neue, einfache Synthese des. 1‐O‐Acetyl‐2,3,5‐Tri‐O‐benzoyl‐β‐<scp>D</scp>‐Ribofuranosides (1959)

Abstract A new simple 3‐step synthesis of 1‐O‐acetyl‐2,3,5‐tri‐O‐benzoyl‐β‐ D ribofuranoside is described. D ‐Ribose is methylated to 1‐O‐methylribofuranoside and the latter benzoylated to 1‐O‐methyl‐2,3,5‐tri‐O‐benzoyl‐ D ‐ribofuranoside. Acetolysis with a mixture of acetic acid, acetic anhydride and sulfuric acid furnishes directly and in good yield pure 1‐O‐acetyl‐2,3,5‐tri‐O‐benzoyl‐β‐ D ‐ribofuranoside.
Novel MOSFET structure using p-n junction gate for ultra-low subthreshold-swing (2011)

As complementary metal oxide semiconductor (CMOS) has been scaled down and supply voltage has been reduced, it becomes important to reduce subthreshold swing (SS) in order to obtain high on/off current ratio. To decrease SS below 60 mV/dec, tunneling field effect transistor (TFET) has been reported and studied recently[1-3]. However, as TFET uses band-to-band tunneling as its current source, it is difficult to obtain high on-current. In order to solve this problem of the conventional TFET and maintain high on-current while lowering SS, novel device using p-n junction gate is proposed in this paper.
Presenting nighttime imagery in daytime colours (2008)

Abstract- We present a fast and efficient method to derive and apply natural colours to nighttime imagery from multiband sensors. The colour mapping is derived from the combination of a multiband image and a corresponding daytime colour reference. The mapping optimizes the match between the multiband image and the reference, and yields a nightvision image with colours similar to the daytime image. The mapping procedure is simple and fast. Once it has been derived the colour mapping can be deployed in realtime. Different colour schemes can be used tailored to the environment and the application. The expectation is that by displaying nighttime imagery in natural colours human observers will be able to interpret the imagery better and faster, thereby improving situational awareness and reducing detection times.
Acetic Acid Upregulates the Expression of Genes for Fatty Acid Oxidation Enzymes in Liver To Suppress Body Fat Accumulation (2009)

We investigated the effect of acetic acid (AcOH) on the prevention of obesity in high-fat-fed mice. The mice were intragastrically administrated with water or 0.3 or 1.5% AcOH for 6 weeks. AcOH administration inhibited the accumulation of body fat and hepatic lipids without changing food consumption or skeletal muscle weight. Significant increases were observed in the expressions of genes for peroxisome-proliferator-activated receptor alpha (PPARalpha) and for fatty-acid-oxidation- and thermogenesis-related proteins: acetyl-CoA oxidase (ACO), carnitine palmitoyl transferase-1 (CPT-1), and uncoupling protein-2 (UCP-2), in the liver of the AcOH-treatment groups. PPARalpha, ACO, CPT-1, and UCP-2 gene expressions were increased in vitro by acetate addition to HepG2 cells. However, the effects were not observed in cells depleted of alpha2 5'-AMP-activated protein kinase (AMPK) by siRNA. In conclusion, AcOH suppresses accumulation of body fat and liver lipids by upregulation of genes for PPARalpha and fatty-acid-oxidation-related proteins by alpha2 AMPK mediation in the liver.
A general CT reconstruction algorithm for model-based material decomposition (2018)

Material decomposition in CT has the potential to reduce artifacts and improve quantitative accuracy by utilizing spectral models and multi-energy scans. In this work we present a novel Model-Based Material Decomposition (MBMD) method based on an existing iterative reconstruction algorithm derived from a general non-linear forward model. A digital water phantom with inserts containing different concentrations of calcium was scanned on a kV switching system. We used the presented method to simultaneously reconstruct water and calcium material density images, and compared the results to an image domain and a projection domain decomposition method. When switching voltage every other frame, MBMD resulted in more accurate water and calcium concentration values than the image domain decomposition method, and was just as accurate as the projection domain decomposition method. In a second, slower, kV switching scheme (changing voltage every ten frames) which precluded the use of traditional projection domain based methods, MBMD continued to produce quantitatively accurate reconstructions. Finally, we present a preliminary study applying MBMD to a water phantom containing vials of different concentrations of K<sub>2</sub>HPO<sub>4</sub> which was scanned on a cone-beam CT test bench. Both the fast and slow (emulated) kV switching schemes resulted in similar reconstructions, indicating MBMD's robustness to challenging acquisition schemes. Additionally, the K<sub>2</sub>HPO<sub>4</sub> concentration ratios between the vials were accurately represented in the reconstructed K<sub>2</sub>HPO<sub>4</sub> density image.
Deep-P encapsulated 4H-SiC trench MOSFETs with ultra low RonQgd (2018)

Deep-P encapsulated 4H-SÌC trench MOSFET was proposed. The fabricated MOSFET with a blocking voltage of 1800V demonstrated a ultra low RonQgd of 133 nCmΩ. The structure optimization was carried out for switching-loss reduction. The improved switching characteristics were obtained by the balanced JFET resistance and the gate-drain capacitance.