gebhart/patrepeval huggingface dataset:
Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae. (1990)

Casein kinase II of Saccharomyces cerevisiae contains two distinct catalytic subunits, alpha and alpha', which are encoded by the CKA1 and CKA2 genes, respectively. Null mutations in the CKA1 gene do not confer a detectable phenotype (J. L.-P. Chen-Wu, R. Padmanabha, and C. V. C. Glover, Mol. Cell. Biol. 8:4981-4990, 1988), presumably because of the presence of the CKA2 gene. We report here the cloning, sequencing, and disruption of the CKA2 gene. The alpha' subunit encoded by the CKA2 gene is 60% identical to the CKA1-encoded alpha subunit and 55% identical to the Drosophila alpha subunit (A. Saxena, R. Padmanabha, and C. V. C. Glover, Mol. Cell. Biol. 7:3409-3417, 1987). Deletions of the CKA2 gene were constructed by gene replacement techniques. Haploid cells in which the CKA2 gene alone is disrupted show no detectable phenotype, but haploid cells carrying disruptions in both the CKA1 and CKA2 genes are inviable. Cells in which casein kinase II activity is depleted increase substantially in size prior to growth arrest, and a significant fraction of the arrested cells exhibit a pseudomycelial morphology. Disruption of the activity also results in flocculation. Yeast strains lacking both endogenous catalytic subunit genes can be rescued by expression of the alpha and beta subunits of Drosophila casein kinase II or by expression of the Drosophila alpha subunit alone, suggesting that casein kinase II function has been conserved through evolution.
Biochemical Studies on Copper, Copper Oxidase, Magnesium, Sulfur, Calcium and Phosphorus in Cancer of the Larynx (1966)

In patients with squamous cell carcinoma of the larynx the blood serum copper concentrations are very increased, and the copper oxidase activity falls with the normal range. The inorganic sulfur concentrations of the serum are increased, and the magnesium concentrations have normal values. Copper contents of the tumoral larynx tissues are very increased and magnesium contents are decreased. The calcium and phosphorus contents are similar in tumoral and normal tissues.Bei Patienten mit Larynxkarzinom sind die Blutkonzcntrationen des Kupfers bcdeutend hölier und die Aktivität der Kapferoxidase steht auf normalen Werten. Die Serumkonzentrationen des inorganischen Schwefels zeigen höhere Wcrte an und die des Magnesiums sind normal. Der Kupfergehalt des tumoralen La-rynxgewebes ist wesentlich erhöht und der des Magnesiums steht unter den normalen Werten. Kalcium und Phosphorgehalte sind gleich in den normalen sowie audi in den tumoralen Geweben.
Selected agglutinated larger foraminifera from the Font de les Bagasses unit (early Campanian, southern Pyrenees) (2015)

The Font de les Bagasses marls and marly limestones (Montsec Mountains, NE Spain) host a rich assemblage of larger foraminifera, that was described for the first time in the early 20th Century from the currently submerged locality of Tragó de Noguera (Marginal Mountains). In this paper, a detailed architectural study has been carried out on selected, agglutinated larger foraminifera, which include Choffatella aff. rugoretis Gendrot, Hemicyclammina chalmasi (Schlumberger), Cuneolina conica Orbigny, Cuneolina cylindrica Henson, and Dictyopsella kiliani Munier-Chalmas. Moreover, it presents their biostratigraphic range and the range of the associated porcellaneous and lamellar-perforate foraminifera in the study area. The assemblage is Early Campanian in age.
Matching Perspective Images Using Geometric Constraints And Perceptual Grouping (2005)

International audience
Chemical composition, nutritive value, and toxicological evaluation of two species of sweet lupine (Lupinus albus and Lupinus luteus) (1980)

Two species of sweet Lupine, Lupinus albus and Lupinus luteus, were analyzed. Both species were good sources of protein (34 and 39%). Lipid content measured as ether extract was 10.9%for L. albus and 4.7% for L. luteus. Both legumes had high crude fiber contents of more than 10%and low alkaloid contents (0.05 and 0.09%). The protein efficiency ratio was low in both species (0.48 and 0.99), but supplementation with DL-methionine increased base values significantly (p < 0.01), 2.84 and 2.30, respectively. In a toxicity study with rats that consumed a 20% lupine protein diet (supplemented with 0.3% DL-methionine), the growth rate of animals fed L. luteus and L. albus was similar to that produced by an unsupplemented 20% protein casein diet. The weight of liver, kidneys, heart, spleen, and adrenals and the histology of kidneys and lungs were normal. © 1980, American Chemical Society. All rights reserved.
Electronic Structure of Chemically-Delithiated LiCoO<sub>2</sub> Studied by Electron Energy-Loss Spectrometry (2002)

The electronic structure of chemically delithiated Li1-xCoO2 (x = −0.02, 0.09, 0.12, 0.20, and 0.28) was investigated by electron energy-loss spectrometry (EELS). The O K edge and Co L2,3 edge were used to probe the density of unoccupied states around the O and Co ions at different states of lithiation. The O ions accommodate the incoming charge during Li intercalation. The net electron density surrounding the Co ions is less affected. This is in substantial agreement with prior electronic structure calculations of Van der Ven, et al., whose atomic structure data were used in the present calculations of EELS cross-sections. Calculations of the O 2p partial densities of state curves confirm the increase in unoccupied states that accompany Li extraction.
Fast progressive reconstruction of a transformed image (Corresp.) (1984)

Fast methods for performing progressive reconstruction of Fourier and Hadamard transformed images have been developed. Reconstruction of an <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N \times N</tex> point transformed image can be evaluated in order <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N^{2} \log_{2} N</tex> instructions. Accumulation of round-off errors due to iteration is reduced by the factor <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(\log_{2} N + 1) / N^{2}</tex> , compared with direct evaluation of the inverse transform.
RAPID Lithography: New Photoresists Achieve Nanoscale Resolution (2011)

Over the past decade, researchers have shattered the traditional view of the diffraction limit. Using new techniques, they have obtained resolution far smaller than the wavelength of light excitation or emission. Similar concepts are now being applied to photolithography, making it possible to create nanoscale features in a photoresist using visible or near-infrared light.
Sex Differences in Short-Term Outcomes After Acute Ischemic Stroke (2014)

Female sex was associated with the risk of poor functional outcome at discharge after acute ischemic stroke.
[Intracellular calcium level, lipid peroxidation, and development of gastric mucosal injury in rat hemorrhagic shock]. (1991)

Although acute gastric mucosal lesions (AGMLs) develop after the mucosal ischemia and reperfusion, precise intracellular mechanism for the development of AGMLs remains unclear. In the present paper, we investigated intracellular calcium level, lipid peroxidation, and gastric mucosal lesion in rat hemorrhagic shock model. We estimated intracellular calcium by measuring phosphorylase a activity in the gastric mucosa. The mucosal phosphorylase a increased during hemorrhagic shock, while it returned to be normal after the reinfusion of shed blood. Although mucosal lipid peroxide and area of AGMLs did not increase significantly during hemorrhagic shock, they increased significantly after the reinfusion. Diltiazem, a calcium antagonist, prohibited both of the increase in mucosal phosphorylase a activity during hemorrhagic shock and the increase in lipid peroxide content and area of AGMLs after the reinfusion of the shed blood. Organ reflectance spectrophotometry revealed that the gastric corpus suffered mucosal ischemia and hypoxia during the hemorrhagic shock. The are of AGMLs had a good correlation with a level of lipid peroxidation in the gastric mucosa. These results suggest 1) that intracellular free calcium in gastric mucosa increases during the mucosal ischemia; 2) that a calcium antagonist prohibits the increased intracellular free calcium during mucosal ischemia; and 3) that a calcium antagonist prohibits the increased mucosal lipid peroxide and the development of AGMLs after the mucosal reperfusion. Thus it is concluded that the increased intracellular free calcium during ischemia plays a key role in the mucosal tissue injury in the ischemia-reperfusion state.
A WHIM satisfactorily addressed (2014)

In this issue of Blood, McDermott et al present the intriguing, clinically relevant, and perhaps unexpected findings for the efficacy and safety of long-term administration of low-dose plerixafor treatment of patients with warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome.
High‐resolution transforms and amplitude preservation (2002)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2002High‐resolution transforms and amplitude preservationAuthors: Michel SchonewillePaul ZwartjesMichel SchonewillePGS Geophysical and Paul ZwartjesDelft University of Technologyhttps://doi.org/10.1190/1.1817108 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1817108FiguresReferencesRelatedDetailsCited byAn efficient deep learning method for VSP wavefield separation: A DAS-VSP caseXiaobin Li, Qiaomu Qi, He Huang, Yuyong Yang, Pengfei Duan, and Zhonglin Cao9 October 2023 | GEOPHYSICS, Vol. 88, No. 6Vertical Seismic Profile Wavefield Separation Using Median Filtering Constrained by the Linear Radon Transform31 August 2018 | Applied Sciences, Vol. 8, No. 9A fast, modified parabolic Radon transformBrahim Abbad, Bjørn Ursin, and Milton J. Porsani18 January 2011 | GEOPHYSICS, Vol. 76, No. 1Multiple attenuation with a modified parabolic Radon transformB. Ursin*, B. Abbad, and M. J. Porsani28 April 20143D surface-related multiple elimination using parabolic sparse inversionKetil Hokstad and Roger Sollie11 October 2006 | GEOPHYSICS, Vol. 71, No. 6 SEG Technical Program Expanded Abstracts 2002 ISSN (print):1052-3812 ISSN (online):1949-4645 Copyright: 2002 Pages: 2478 publication data© 2002 Copyright © 2002 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 03 Jan 2005 CITATION INFORMATION Michel Schonewille and Paul Zwartjes, (2002), "High‐resolution transforms and amplitude preservation," SEG Technical Program Expanded Abstracts : 2066-2069. https://doi.org/10.1190/1.1817108 Plain-Language Summary PDF DownloadLoading ...
Three-Dimensional Interconnected Network of Graphene-Wrapped Porous Silicon Spheres: In Situ Magnesiothermic-Reduction Synthesis and Enhanced Lithium-Storage Capabilities (2014)

A novel type of 3D porous Si-G micro/nanostructure (i.e., 3D interconnected network of graphene-wrapped porous silicon spheres, Si@G network) was constructed through layer-by-layer assembly and subsequent in situ magnesiothermic-reduction methodology. Compared with bare Si spheres, the as-synthesized Si@G network exhibits markedly enhanced anodic performance in terms of specific capacity, cycling stability, and rate capability, making it an ideal anode candidate for high-energy, long-life, and high-power lithium-ion batteries.
Pharmacological analysis of CCK<sub>2</sub> receptor antagonists using isolated rat stomach ECL cells (1999)

1. Gastrin stimulates rat stomach ECL cells to secrete histamine and pacreastatin, a chromogranin A (CGA)-derived peptide. The present report describes the effect of nine cholecystokinin2 (CCK2) receptor antagonists and one CCK1 receptor antagonist on the gastrin-evoked secretion of pancreastatin from isolated ECL cells. 2. The CCK2 receptor antagonists comprised three benzodiazepine derivatives L-740,093, YM022 and YF476, one ureidoacetamide compound RP73870, one benzimidazole compound JB 93182, one ureidoindoline compound AG041R and three tryptophan dipeptoids PD 134308 (CI988), PD135158 and PD 136450. The CCK1 receptor antagonist was devazepide. 3. A preparation of well-functioning ECL cells (approximately 80% purity) was prepared from rat oxyntic mucosa using counter-flow elutriation. The cells were cultured for 48 h in the presence of 0.1 nM gastrin; they were then washed and incubated with antagonist alone or with various concentrations of antagonist plus 10 nM gastrin (a maximally effective concentration) for 30 min. Gastrin dose-response curves were constructed in the absence or presence of increasing concentrations of antagonist. The amount of pancreastatin secreted was determined by radioimmunoassay. 4. The gastrin-evoked secretion of pancreastatin was inhibited in a dose-dependent manner. YM022, AG041R and YF476 had IC50 values of 0.5, 2.2 and 2.7 nM respectively. L-740,093, JB93182 and RP73870 had IC50 values of 7.8, 9.3 and 9.8 nM, while PD135158, PD136450 and PD134308 had IC50 values of 76, 135 and 145 nM. The CCK1 receptor antagonist devazepide was a poor CCK2 receptor antagonist with an IC50 of about 800 nM. 5. YM022, YF476 and AG041R were chosen for further analysis. YM022 and YF476 shifted the gastrin dose-response curve to the right in a manner suggesting competitive antagonism, while the effects of AG041R could not be explained by simple competitive antagonism. pK(B) values were 11.3 for YM022, 10.8 for YF476 and the apparent pK(B) for AG041R was 10.4.
Private Ordering In Light of the Law: Achieving Consumer Protection Through Payment Card Security Measures (2011)

A private ordering regime has developed within the payment card industry to define appropriate security practices and to monitor compliance by network participants. Market demands for trustworthy systems upon which consumers and merchants could rely provide incentives for security, which the card brands supplement by privately designed fines and sanctions imposed through contract. Although private ordering has functioned sufficiently well to make payment cards a trusted payment method, the system is not completely secure, as data security breaches continue to occur. This is not surprising, as complete security is not a feasible goal. Nevertheless, some have questioned whether additional government regulation is necessary to protect consumers. This Article explores the effects of legal intervention, including disclosure laws, on this private ordering system. It questions whether additional government intervention would enhance consumer welfare, particularly when consumers will likely bear the ultimate costs of such regulation. It recommends modifications in breach disclosure laws to eliminate individual notice requirements in favor of public notices, which may reduce costs and enhance consumer welfare. It challenges bounty enforcement regimes, such as FACTA, which offer little marginal benefit to consumers while substantially raising costs. It identifies practical and political problems presented by the different capacities of large and small firms to bear security costs, which are not easily solved under either private ordering or legislative approaches. Finally, it offers a set of policy issues as a possible agenda for consideration by policy makers and researchers in this domain. * Professor of Law, McGrath North Mullin & Kratz Endowed Chair in Business Law, Creighton University School of Law. ** Professor of Accounting, Creighton University College of Business Administration. The authors are grateful for comments and insights on an earlier version of this paper from participants at Economic Governance and Competition: The Pros and Cons of Private Ordering in the Shadow of the Law, held at Tilburg University, The Netherlands.
Histone fold modifications control nucleosome unwrapping and disassembly (2011)

Nucleosomes are stable DNA-histone protein complexes that must be unwrapped and disassembled for genome expression, replication, and repair. Histone posttranslational modifications (PTMs) are major regulatory factors of these nucleosome structural changes, but the molecular mechanisms associated with PTM function remains poorly understood. Here we demonstrate that histone PTMs within distinct structured regions of the nucleosome directly regulate the inherent dynamic properties of the nucleosome. Precise PTMs were introduced into nucleosomes by chemical ligation. Single molecule magnetic tweezers measurements determined that only PTMs near the nucleosome dyad increase the rate of histone release in unwrapped nucleosomes. In contrast, FRET and restriction enzyme analysis reveal that only PTMs throughout the DNA entry-exit region increase unwrapping and enhance transcription factor binding to nucleosomal DNA. These results demonstrate that PTMs in separate structural regions of the nucleosome control distinct dynamic events, where the dyad regulates disassembly while the DNA entry-exit region regulates unwrapping. These studies are consistent with the conclusion that histone PTMs may independently influence nucleosome dynamics and associated chromatin functions.
Mar Salgado: Fernando Pessoa perante uma acusação de plágio (2013)

Partindo da análise de um pequeno poema de Fernando Pessoa revelado em 2000, no qual o escritor reage a uma acusação de plágio relacionada com alguns versos do seu famoso poema Mar Português, este artigo situa cronologicamente o caso, revela a origem dessa acusação e enquadra historicamente o episódio, sublinhando o simbolismo político de que se revestiu. Pessoa foi acusado em Março de 1935 por um correspondente do semanário literário Fradique de se ter apropriado de expressões de uma velha quadra de António Correia de Oliveira, que nos anos 30 se estava a consagrar como o poeta oficial do regime de Salazar. Isso aconteceu no seguimento da inesperada ruptura pública de Pessoa com o Estado Novo, que ocorreu apenas um mês depois de o livro Mensagem, integrando o poema Mar Português, ter recebido um prémio governamental. O caso da acusação de plágio opôs assim não só dois poetas destacados como também duas atitudes muito diferentes em relação ao regime de Salazar.
Tin dioxide nano-wire device for sensing kinetics of acetone and ethanol towards diabetes monitoring (2013)

We demonstrate how to establish reliable contacts to SnO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> nano-wires by growing these nano-wire on-chip on gold contacts deposited on alumina. The sensor device is used to sense the concentrations of acetone and ethanol in air and their reaction kinetics. Acetone molecules have higher adsorption and desorption rates on SnO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> nanowires than ethanol molecules which leads to a lower critical acetone concentration at which the SnO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> sensor saturates than is the case for ethanol. These differences suggest a new way of introducing selectivity to the notoriously non-selective SnO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> and other oxide-based nano-scale sensors.
Acurex Parabolic Dish Concentrator (PDC-2) (1982)

The design approach, rationale for the selected configuration, and the development status of a cost effective point-focus solar concentrator are discussed. The low-cost concentrator reflective surface design is based on the use of a thin, backsilvered mirror glass reflector bonded to a molded structural plastic substrate. The foundation, support, and drive subassembles are described. A hybrid, two-axis, Sun tracking control system based on microprocessor technology was selected. Coarse synthetic tracking is achieved through a microcomputer-based control system to calculate Sun position for transient periods of cloud cover as well as sundown and sunrise positioning. Accurate active tracking is achieved by two-axis optical sensors. Results of the reflective panel demonstration tests investigating slope error, hail impact survivability, temperature/humidity cycling, longitudinal strength/bending stiffness, and torsional stiffness are discussed.
Magnesium Ethylenediamine Borohydride as Solid-State Electrolyte for Magnesium Batteries (2017)

Solid-state magnesium ion conductors with exceptionally high ionic conductivity at low temperatures, 5 × 10<sup>-8</sup> Scm<sup>-1</sup> at 30 °C and 6 × 10<sup>-5</sup> Scm<sup>-1</sup> at 70 °C, are prepared by mechanochemical reaction of magnesium borohydride and ethylenediamine. The coordination complexes are crystalline, support cycling in a potential window of 1.2 V, and allow magnesium plating/stripping. While the electrochemical stability, limited by the ethylenediamine ligand, must be improved to reach competitive energy densities, our results demonstrate that partially chelated Mg<sup>2+</sup> complexes represent a promising platform for the development of an all-solid-state magnesium battery.
Fermentation of Fragrances: Biotransformation of β‐Ionone by Lasiodiplodia theobromae (1982)

Abstract Pre‐grown mycelia of Lasiodiplodia theobromae ATCC 28570 transform β‐ionone (1) into a large variety of metabolites, by mainly degrading the side‐chain of the β‐ionone molecule by a C 2 ‐unity. The enzyme system responsible for this degradation is proposed to be an oxygenase, which gives rise to the formation of the main product β‐cyclo‐homogeraniol (8) in analogy to a Baeyer‐ Villiger oxidation. Further enzymic actions of Lasiodiplodia such as hydrogenations and hydroxylations lead to an accumulation of several not yet described β‐ionone metabolites.
Coincorporation of LpxL1 and PagL Mutant Lipopolysaccharides into Liposomes with<i>Neisseria meningitidi</i>s Opacity Protein: Influence on Endotoxic and Adjuvant Activity (2010)

Wild-type lipopolysaccharide (LPS) of Neisseria meningitidis normally contains six acyl chains. Penta-acylated LPS forms were generated through inactivation of the lpxL1 gene or through the expression of the Bordetella bronchiseptica pagL gene in N. meningitidis. The resulting LPS species, designated LpxL1 LPS and PagL LPS, respectively, display reduced endotoxic activity compared to wild-type LPS. Here, we determined the adjuvant potential of PagL LPS by comparison with the broadly used LpxL1 LPS. We also investigated the potential benefit for adjuvanticity of coincorporating these LPS species, together with the meningococcal opacity-associated protein OpaJ as a model antigen, in a liposomal delivery system. PagL LPS showed a higher endotoxic activity than LpxL1 LPS, and their incorporation into liposomes significantly reduced their endotoxic activity as determined by measuring the induction of interleukin-6 (IL-6) production in a murine macrophage cell line. To determine the adjuvant effect, BALB/c mice were immunized with OpaJ-containing liposomes and either free LPS or LPS coincorporated into the proteoliposomes. OpaJ-containing liposomes adjuvanted with AlPO(4) or not adjuvanted at all were included as control groups. In the appropriate dose, PagL LPS showed a superior adjuvant effect compared with LpxL1 LPS, and for both LPS types, free LPS showed a higher adjuvant effect than when coincorporated into the liposomes, as evidenced by higher titers of IgG2a and IgG2b antibodies against OpaJ(+) meningococci and higher bactericidal titers. In conclusion, PagL LPS is a better adjuvant than LpxL1 LPS, but coincorporation of either LPS into proteoliposomes did not improve their adjuvant activity.