gebhart/patrepeval huggingface dataset:
Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors (2018)

Melanoma is one of the fastest growing cancers in the United States and is accompanied with a poor prognosis owing to tumors being resistant to most therapies. Atypical protein kinase Cs (aPKC) are involved in malignancy in many cancers. We previously reported that aPKCs play a key role in melanoma's cell motility by regulating cell signaling pathways which induce epithelial-mesenchymal Transition (EMT). We tested three novel inhibitors; [4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl] methyl dihydrogen phosphate (ICA-1T) along with its nucleoside analog 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide (ICA-1S) which are specific to protein kinase C-iota (PKC-ι) and 8-hydroxy-1,3,6-naphthalenetrisulfonic acid (ζ-Stat) which is specific to PKC-zeta (PKC-ζ) on cell proliferation, apoptosis, migration and invasion of two malignant melanoma cell lines compared to normal melanocytes. Molecular modeling was used to identify potential binding sites for the inhibitors and to predict selectivity. Kinase assay showed >50% inhibition for specified targets beyond 5 μM for all inhibitors. Both ICA-1 and ζ-Stat significantly reduced cell proliferation and induced apoptosis, while ICA-1 also significantly reduced migration and melanoma cell invasion. PKC-ι stimulated EMT via TGFβ/Par6/RhoA pathway and activated Vimentin by phosphorylation at S39. Both ICA-1 and ζ-Stat downregulate TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis. Results suggest that PKC-ι is involved in melanoma malignancy than PKC-ζ. Inhibitors proved to be effective under <i>in-vitro</i> conditions and need to be tested <i>in-vivo</i> for the validity as effective therapeutics. Overall, results show that aPKCs are essential for melanoma progression and metastasis and that they could be used as effective therapeutic targets for malignant melanoma.
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity (2020)

The blood-brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain's metabolic activity as well as neuronal function. Thus, the functional and structural integrity of the BBB is pivotal to maintain the homeostasis of the brain microenvironment. The different cells and structures contributing to developing this barrier are summarized along with the different functions that BBB plays at the brain-blood interface. We also explained the role of shear stress in maintaining BBB integrity. Furthermore, we elaborated on the clinical aspects that correlate between BBB disruption and different neurological and pathological conditions. Finally, we discussed several biomarkers that can help to assess the BBB permeability and integrity in-vitro or in-vivo and briefly explain their advantages and disadvantages.
Carotid Endarterectomy Without Temporary Intraluminal Shunt Study of 309 Consecutive Operations (1980)

A prospective study was undertaken to determine the efficacy of performing carotid endarterectomy without an intraluminal shunt. During a two-year period, 240 patients, ranging in age from 36 to 89 years, underwent 309 consecutive carotid endarterectomies. The indication for operation was transient ischemic attacks in 151 (63%) patients, asymptomatic carotid bruit in 67 (28%), and previous stroke in 22 (9%). Internal shunts were not used in any patients and all arteriotomies were patched with a preclotted knitted Dacron velor patch. Systemic heparinization was used during the procedure. The early postoperative mortality was 0.64% (2/309). Both deaths were caused by myocardial infarction. The incidence of stroke after operation was 1.29% (4/309). Neither carotid clamp time nor the presence of contralateral disease correlated with the occurrence of postoperative stroke. According to results of angiography, 22 patients had total occlusion of the contralateral internal carotid artery with satisfactory intracranial circulation. No postoperative strokes occurred in this subgroup. Results of this study revealed that equally good or superior results may be obtained without a temporary shunt in performing carotid endarterectomy.
Applying QR code in augmented reality applications (2009)

In this paper we present an augmented reality (AR) application based on the QR Code. The system can extract the information embedded in a QR Code and show the information in an extended 3D form with the QR Code being the traditional AR marker. Traditional AR systems often use a particularly designed pattern (the marker) to recover the 3D scene structure and identify the object to be displayed on the scene. In these systems, the marker is used only for tracking and identification. They do not convey any other information. Consequently, the applications of these systems are limited and often a registration procedure is required for a new marker.
Divertor neutral pressure enhancement with a baffle in DIII-D (1993)

The open divertor in DIII-D has been modified by the installation of a baffled plenum with a narrow entrance aperture. Neutral particle pressures in the range of 2-20 mtorr have been measured in this new plenum during experiments in L and H mode plasmas in which the neutral beam power was varied and the divertor target location was scanned with respect to the entrance aperture. These pressures exceed the predicted minimum required to provide adequate particle exhaust for controlling the density in H mode discharges when pumping experiments are conducted in the future. The pressure measurements presented here, which were carried out in the absence of a pump, were modelled with the aid of two transport codes: an edge plasma code and a neutrals code. It was found in this modelling process that the divertor flux amplification factor required to explain the measured pressures is of the order of 30 to 40, much higher than the factors used in the modelling of data in the absence of the baffle. This higher flux amplification factor results from increased recycling at the divertor owing to the presence of the baffle
A multicenter, blinded, randomized, factorial controlled trial of doxycycline and rifampin for treatment of Alzheimer's disease: the DARAD trial (2012)

Twelve months' treatment with doxycycline or rifampin, alone or in combination, has no beneficial effects on cognition or function in AD.
“Venetian-blind” direct energy converter for fusion reactors (1973)

A new direct energy conversion technique that uses the angular-dependent transmission of ribbon grids, which resemble Venetian blinds, to recover the energy of particles leaking out of a fusion reactor is discussed. This converter works well, even to energies as low as 10 keV, because of its excellent space-charge handling ability. This low-energy operating range makes direct energy conversion possible on closed confinement devices; operation at about 100 keV might be useful on open confinement devices. Energy recovery efficiencies of 60 to 70% are predicted. Examples are presented in which a direct energy converter with efficiencies in this range, when viewed as a topping cycle to a thermal converter, could considerably improve the reactor prospects of both open- and closed-field-line confinement schemes.
Biology of Renal Recovery: Molecules, Mechanisms, and Pathways (2014)

Acute kidney injury (AKI) contributes to progressive kidney disease. Although significant advances have been made in the understanding of mechanisms of AKI, less is known about the biological basis that links the initial injury to progressive interstitial fibrosis, tubular dysfunction, and capillary rarefaction. The round table discussion focused on mechanisms of renal recovery and fibrosis following AKI. The knowledge gained by understanding these pathways will serve to identify novel therapeutic targets in the future.
Assay of the Multiple Energy-Producing Pathways of Mammalian Cells (2011)

This technology can be employed as a fundamental tool in genotype-phenotype studies to determine changes in cells from shared lineages due to differentiation or mutation.
Inspection and Introspection (1940)

The philosophy of science embraces the metaphysical, epistemological and methodological problems which arise in the study of the special sciences and perhaps no branch of the philosophy of science is more deserving of careful investigation than the borderline discipline between philosophy and scientific psychology. The philosophical problems resulting from the impact of psychology upon philosophy include such traditional problems as the existence, nature and origin of consciousness, the relation of the conscious to the unconscious and subconscious mind, the nature and continuity of the self, and the relation of consciousness to its neural conditions. All these problems originate in empirical psychology and are soluble, if at all, only by appeal to psychological evidence and thus through the cooperative efforts of the philosopher and the psychologist. Unfortunately the gulf between philosophers and psychologists is as wide if not wider than that which exists between philosophers and other groups of scientists. The chief obstacle to a philosophical psychology is the alienation of psychology from philosophy which followed the attainment by psychology of its status as an independent science. Psychology as a young and vigorous science, revolting against the parental restraint of philosophy, utterly repudiated philosophy and philosophical modes of thought and, at the same time, philosophy on its side breathed a sigh of relief to be rid of a difficult and recalcitrant offspring. Thus psychological science became more hostile to philosophy than her elder sister sciences, and philosophy went its own speculative way in utter disregard of scientific psychology. Indeed “Psychologismus” has become among philosophers a term of such severe reproach that to refute a philosophical position in certain quarters one need only demonstrate that it is psychological in its origin and foundation. Thus the revolt of psychology against philosophy, natural and inevitable though it was, has been so violent and prolonged as to be detrimental to both psychology and philosophy alike.
[New therapeutic alternatives in migraine prophylaxis using histamine H3 receptor agonists]. (2008)

The present study provides evidence on the safety and efficiency of subcutaneous histamine administered at a dose of 1-10 microg twice weekly. This treatment constitutes a new therapeutic alternative, and provides a clinical and pharmacological basis for the use of H3 histaminergic agonists in migraine prophylaxis.
Evaluation of diagnostic tests used for detection of bovine viral diarrhea virus and prevalence of subtypes 1a, 1b, and 2a in persistently infected cattle entering a feedlot (2006)

Rapid tests such as ACE permit identification and segregation of PI cattle pending results of further tests, thus reducing their contact with the rest of the feedlot population. Although vaccines with BVDV1a and 2a components are given to cattle entering feedlots, these vaccines may not provide adequate protection against BVDV1b.
Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease (2013)

Protein misfolding and metal ion dyshomeostasis are believed to underlie numerous neurodegenerative diseases, including Alzheimer's disease (AD). The pathological hallmark of AD is accumulation of misfolded amyloid-β (Aβ) peptides and hyperphosphorylated tau (ptau) proteins in the brain. Since AD etiology remains unclear, several hypotheses have emerged to elucidate its pathological pathways. The amyloid cascade hypothesis, a leading hypothesis for AD development, advocates Aβ as the principal culprit. Additionally, evidence suggests that tau may contribute to AD pathology. Aβ and tau have also been shown to impact each other's pathology either directly or indirectly. Furthermore, metal ion dyshomeostasis is associated with these misfolded proteins. Metal interactions with Aβ and tau/ptau also influence their aggregation properties and neurotoxicity. Herein, we present current understanding on the roles of Aβ, tau, and metal ions, placing equal emphasis on each of these proposed features, as well as their inter-relationships in AD pathogenesis.
Semi‐Classical Asymptotic of Spectral Function for Some Schrödinger Operators (1986)

Abstract In this paper one obtains a result concerning the asymptotic behaviour of the spectral function on the diagonal for SCHRÖDINGER operators A h = – h 2 /2 λ + V as h → 0. This asymptotic change the form on the energy level V ( x ) = λ.
Frame-parallel design strategy for high definition B-frame H.264/AVC encoder (2008)

High Definition (HD) H.264/AVC video compression is the emerging necessity on nowadays home entertainment environment and so on. However, Although B-frame coding scheme provides better quality, only P-frame encoders are presented due to too high complexity and memory requirement. In this paper, a frame-parallel encoding scheme based on B-frame’s data independency is proposed. It can largely reduce the system memory bandwidth and improve the processing capability. Then, the proposed IME and FME scheduling can further enhance the hardware utilization for frame-parallel scheme. Finally, a case study is given to show that the proposed scheme can largely reduce 66% system bandwidth compared to direct implementation from previous P-frame encoder.
Effects of stress memory by fear conditioning on nerve-mast cell circuit in skin (2010)

Inflammatory skin disorder aggravates when a horrific memory is evoked, but the mechanism of this effect is unclear. The objective of the present study was to examine the effects of evocation of a horrific memory on the skin and mast cells in an animal model. A sound stimulus linked to an electric shock was given to C57BL/6 mice (7-week old, males). One, 3 and 5 days later, the mice received the sound stimulus again. The reactions of mice that received the initial sound stimulus were compared with those of mice that did not receive the initial stimulus. A freezing phenomenon was observed when the sound stimulus was given to mice that received the initial stimulus, which indicated evocation of a past memory of fear. The degranulation rate of dermal mast cells and the length of substance P (SP)-positive nerve fibers of the skin significantly increased on days 1 and 3, the SP level decreased significantly, and the number of SP-expressing cells in the dorsal root ganglion significantly increased on day 1. These findings suggest that prior experience of severe stress linked to a stimulus subsequently evokes fear associated with the same stimulus and results in activation of dermal mast cells and skin nerves.
Subband coding of color images using finite state vector quantization (2003)

Subband coding (SBC) has been shown to be an effective method for coding monochrome images at low bit rates. SBC systems decompose the input image into a small number of decimated, spectrally disjoint subband images which are then coded by a variety of means. Reconstruction is performed by decoding and merging the reinterpolated subband images. This work investigates the application of the subband concept to the efficient coding of color images. The color representations are cast into a subband coding framework to form color image coding systems. Differential PCM and finite-state vector quantization methods are used in coding the subband images. Bit rates below 1 bit/pixel are obtainable for high-quality representations of 256*256 color images.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Women and Guilds in Bologna: The Ambiguities of “Marginality” (1998)

Research Article| January 01 1998 Women and Guilds in Bologna: The Ambiguities of “Marginality” Dora Dumont Dora Dumont Search for other works by this author on: This Site Google Radical History Review (1998) 1998 (70): 4–25. https://doi.org/10.1215/01636545-1998-70-4 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Dora Dumont; Women and Guilds in Bologna: The Ambiguities of “Marginality”. Radical History Review 1 January 1998; 1998 (70): 4–25. doi: https://doi.org/10.1215/01636545-1998-70-4 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter Books & JournalsAll JournalsRadical History Review Search Advanced Search The text of this article is only available as a PDF. Copyright © 1998 by MARHO: The Radical Historians' Organization, Inc.1998 Article PDF first page preview Close Modal Issue Section: Feature Articles You do not currently have access to this content.
Privacy Preserving Confidential Forensic Investigation for Shared or Remote Servers (2011)

It is getting popular that customers make use of third party data service providers to store their data and emails. It is common to have a large server shared by many different users. This creates a big problem for forensic investigation. It may not be easy to clone a copy of data from the storage device(s) due to the huge volume of data. Even if it is possible to make a clone, there are many irrelevant information/data stored in the same device for which the investigators have no right to access. The other alternative is to let the service provider search the relevant information and retrieve the data for the investigator provided a warrant can be provided. However, sometimes, due to the confidentiality of the crime, the investigator may not want the service provider to know what information they are looking for or the service provider herself may be one of the suspects. The problem becomes even more obvious in terms of cloud computing technology. In this paper, we address this problem and using homomorphic encryption and commutative encryption, we provide two forensically sound schemes to solve the problem so that the investigators can obtain the necessary evidence while the privacy of other users can be protected and at the same time, the service provider cannot know what information the investigators are interested in.
Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease (2008)

BACKGROUND: Higher levels of red blood cell distribution width (RDW) may be associated with adverse outcomes in patients with heart failure. We examined the association between RDW and the risk of all-cause mortality and adverse cardiovascular outcomes in a population of people with coronary disease who were free of heart failure at baseline. METHODS AND RESULTS: We performed a post hoc analysis of data from the Cholesterol and Recurrent Events study. Baseline RDW was measured in 4111 participants who were randomized to receive pravastatin 40 mg daily or placebo and followed for a median of 59.7 months. We used Cox proportional hazards models to examine the association between RDW and adverse clinical outcomes. During nearly 60 months of follow-up, 376 participants died. A significant association was noted between baseline RDW level and the adjusted risk of all-cause mortality (hazard ratio per percent increase in RDW, 1.14; 95% confidence interval, 1.05 to 1.24). After categorization based on quartile of baseline RDW and further adjustment for hematocrit and other cardiovascular risk factors, a graded independent relation between RDW and death was observed (P for trend=0.001). For instance, participants with RDW in the highest quartile had an adjusted hazard ratio for death of 1.78 (95% confidence interval, 1.28 to 2.47) compared with those in the lowest quartile. Higher levels of RDW were also associated with increased risk of coronary death/nonfatal myocardial infarction, new symptomatic heart failure, and stroke. CONCLUSIONS: We found a graded independent relation between higher levels of RDW and the risk of death and cardiovascular events in people with prior myocardial infarction but no symptomatic heart failure at baseline.
Applications of Hansch Analysis (1993)

This chapter contains sections titled: Enzyme Inhibition Other in vitro Data Pharmacokinetic Data Other Biological Data Activity-Activity Relationships
Real-time multi-perspective rendering on graphics hardware (2006)

Multi-perspective rendering has a variety of applications; examples include lens refraction, curved mirror reflection, caustics, as well depiction and visualization. However, multi-perspective rendering is not yet practical on polygonal graphics hardware, which so far has utilized mostly single-perspective (pin-hole or orthographic) projections.In this paper, we present a methodology for real-time multi-perspective rendering on polygonal graphics hardware. Our approach approximates a general multi-perspective projection surface (such as a curved mirror and lens) via a piecewise-linear triangle mesh, upon which each triangle is a simple multi-perspective camera, parameterized by three rays at triangle vertices. We derive analytic formula showing that each triangle projection can be implemented as a pair of vertex and fragment programs on programmable graphics hardware. We demonstrate real-time performance of a variety of applications enabled by our technique, including reflection, refraction, caustics, and visualization.
High quality, scalable and parallel community detection for large real graphs (2014)

Community detection has arisen as one of the most relevant topics in the field of graph mining, principally for its applications in domains such as social or biological networks analysis. Different community detection algorithms have been proposed during the last decade, approaching the problem from different perspectives. However, existing algorithms are, in general, based on complex and expensive computations, making them unsuitable for large graphs with millions of vertices and edges such as those usually found in the real world.
Bis(ethylenedioxy)tetrathiafulvalene: the first oxygen substituted tetrathiafulvalene (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBis(ethylenedioxy)tetrathiafulvalene: the first oxygen substituted tetrathiafulvaleneT. Suzuki, H. Yamochi, G. Srdanov, K. Hinkelmann, and F. WudlCite this: J. Am. Chem. Soc. 1989, 111, 8, 3108–3109Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/ja00190a079https://doi.org/10.1021/ja00190a079research-articleACS PublicationsRequest reuse permissionsArticle Views460Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts