gebhart/patrepeval huggingface dataset:
Online Trajectory Generation: Straight-Line Trajectories (2011)

A concept of online trajectory generation for robot motion control systems that enables instantaneous reactions to unforeseen sensor events was introduced in a former publication. This concept is now extended with the important feature of homothety. Homothetic trajectories are 1-D straight lines in a multidimensional space and are relevant for all straight-line motion operations in robotics. This paper clarifies 1) how online concepts can be used to generate homothetic trajectories and 2) how we can instantaneously react to (sensor) events with homothetic trajectories. To underline the practical relevance, real-world experimental results with a seven-degree-of-freedom (DOF) robot arm are shown.
Selective and sensitive turn-on fluorescent sensing of arsenite based on cysteine fused tetraphenylethene with AIE characteristics in aqueous media (2013)

Herein, a cysteine-functionalized derivative of TPE is presented as the first fluorescent organic dye for selective, label-free, sub-ppb level detection of As(3+) in aqueous media by taking the advantage of the aggregation induced emission feature. Besides, the first discrimination between the most toxic As(3+) and less toxic As(5+) was obtained.
Pro-angiogenic effect of IFNgamma is dependent on the PI3K/mTOR/translational pathway in human retinal pigmented epithelial cells. (2010)

We provide evidence that IFNgamma induces VEGF expression in human retinal pigment epithelial cells. Our work emphasizes that the activation of the PI-3K/mTOR/translational pathway is important for IFNgamma-mediated VEGF expression in RPE cells. By elucidating molecular signaling involved in this process, our findings provide further mechanistic insight into the successful clinical application of rapamycin therapy for choroidal neovascularization in age-related macular degeneration (AMD) and uveitis.
THE INFIDELITY OF CONJUGAL DNA TRANSFER IN <i>ESCHERICHIA COLI</i> (1983)

The accuracy of replication and transfer of a lacI gene on an F' plasmid was measured. Following conjugal transfer of the F', a small but reproducible increase (1.8-fold) in the frequency of lacI- mutations was detected. Among these, however, the frequency of nonsense mutations was 15-fold higher than in the absence of transfer. This corresponds to a 300-fold increase in the rate of base substitutions per round of replication compared with normal vegetative DNA replication. The amber mutational spectra revealed that, following conjugal transfer, mutation frequencies were increased markedly at all sites detected. In addition, an increase in G:C leads to A:T transitions was noted and was due almost entirely to an enhanced proportion of mutants recovered at the spontaneous hotspots (amber sites 6, 15 and 34). recA-dependent processes were not responsible for the increase in mutation, since similar results were observed with various recA- donor and recipient combinations. These results demonstrate that the fidelity of conjugal DNA replication is considerably lower than that of vegetative DNA replication.
Transmitter architecture for faster-than-Nyquist signaling systems (2009)

This paper presents the complexity analysis of a transmitter architecture for a faster-than-Nyquist (FTN) system. Complexity issues in terms of computations and memory requirements to achieve an FTN system are dealt with. An OFDM based multi-carrier system is considered as it is one of the most widely used in upcoming wireless standards. Retaining the modules within the OFDM transmitter helps in exploiting the already optimized and hardware efficient structures, the IFFT being one. From an implementation perspective the introduction of FTN introduces negligible overhead for the transmitter.
Anti-AIDS Agents. 34. Synthesis and Structure−Activity Relationships of Betulin Derivatives as Anti-HIV Agents (1998)

Succinyl and 3'-substituted glutaryl betulin derivatives showed stronger anti-HIV activity and higher therapeutic index (TI) values than their dihydrobetulin counterparts, with ratios of 1.2:1 to 15:1 (cf. 7 and 15, 9 and 17, 10 and 18, 11 and 19, and 12 and 20). For various 3'-substituted glutaryl compounds, the order of anti-HIV effects, from strong to weak inhibition, was 3',3'-dimethyl, 3'-methyl, 3'-ethyl-3'-methyl, followed by 3',3'-tetramethylene glutaryl derivatives (10 > 9 > 11 > 12, 18 > 17 > 19 > 20). The most potent compound, 10, has two 3',3'-dimethylglutaryl groups and displays significant anti-HIV potency with an EC50 value of 0.000 66 microM and a TI of 21 515. Results for compounds (22 and 23) without a C-3 acyl group confirmed the importance of the C-3 acyl group to the anti-HIV effect. With 3',3'-tetramethylene glutaryl derivatives, triacyl 29 showed stronger inhibition than diacyl 12; in contrast, 3',3'-dimethylglutaryl compounds displayed opposite results. 3-Keto compounds (35 and 36) and 2,3-dihydro compounds (39 and 40) had EC50 values in the range of 4.3-10.0 microM, suggesting that A ring modification led to decreased potency. The reduced activity of amide (33 and 34), ester (41), and oxime (42) analogues suggested that the orientation and linkage of the C-3 acyl side chain play crucial roles in the potent anti-HIV activity. Finally, replacing the C-28 acyl group with a bulky non-carboxylic group produced a less potent compound (44). In the study of mechanism of action, our results indicated that fusion is not the primary target for the anti-HIV activity of 10. It appears to inhibit HIV replication at a late stage of the viral life cycle, i.e., after viral protein synthesis.
Extraction of Essential Oil from Nigella sativa Using Supercritical Carbon Dioxide: Study of Antibacterial Activity (2008)

The antimicrobial activity of N. sativa essential oil obtained by supercritical fluid extraction by carbon dioxide was investigated against Gram Positive and Gram negative strains, isolated from clinical specimens. Best conditions for Black cumin oil extraction are obtained at 400 bar, 40°C and a solvent flow rate of 25 g min-1. The seed extracts were prepared by supercritical fluid extraction method. Filter paper discs impregnated with varying concentrations of N. sativa extract were tested by the disk diffusion method. Methicillin Resistant Staphylococcus Aureus (MRSA) ATCC strain (700968), E. coli ATCC strain (25922), E. coli 0157 ATCC strain (12799), Extended-Spectrum Beta-Lactamase (ESBL) Klebsiella pneumoniae ATCC strain (700603), Carbapenam Resistant acenitobacter Baumanii (CRAB) clinical strain and Vibrio cholerae 01 Ogawa and 0139 Bengal clinical strains were investigated. The inhibition zones of the Mueller Hinton agar in different extract concentrate ion showed that at 25 mg 20 μL-1, 50 mg 20 μL-1 and 100 mg 20 μL-1, the inhibition zones increased accordingly in S. aureu. However, N. sativa was found to be inactive against ESBL producers (E. coli and K. pneumoniae).
Pharmacokinetic profile of paclitaxel in the plasma, lung, and diaphragm following intravenous or intrapleural administration in rats (2014)

These results suggest that IP administration may reduce systemic distribution of paclitaxel and increase the concentration in the lung and diaphragm. This could increase therapeutic efficacy by increasing the available drug and reduce systemic toxicity.
Recursive estimation for CAD model recovery (2002)

We describe a system for semiautomatically extracting 3-D object models from raw, uncalibrated video. The system utilizes a recursive estimator to accurately recover camera motion, point-wise structure, and camera focal length. Recovered 3-D points are used to compute a piecewise-smooth surface model for the object. Recovered motion and camera geometry are then used along with the original video to texture map the surfaces. We describe extensions to our previously-reported geometry estimation formulation that incorporate focal length estimation and other improvements, so that accurate estimates of structure and camera motion can be recovered from uncalibrated video cameras. We also discuss the buildup of texture maps from sequences of images, which is important in producing realistic looking models. Examples demonstrate generation of a realistic 3-D texture mapped model from a video sequence, the post-production manipulation of video, and the combination of computer graphics models with video.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Structural basis of the properties of an industrially relevant thermophilic xylanase (1997)

A thermophilic xylanase from Bacillus strain D3 suitable for use as a bleach booster in the paper pulping industry has been identified and characterized. The enzyme is suited to the high temperature and alkaline conditions needed for using xylanases in the pulp industry. The xylanase is stable at 60 degrees C and relatively stable at high temperatures, with a temperature optimum of 75 degrees C. The pH optimum is 6, but the enzyme is active over a broad pH range. The xylanase has been cloned and sequenced, and the crystal structure has been determined. The structure of Bacillus D3 xylanase reveals an unusual feature of surface aromatic residues, which form clusters or "sticky patches" between pairs of molecules. These "sticky patches" on the surface of the enzyme are responsible for the tendency of the protein to aggregate at high concentrations in the absence of reagents such as ethylene glycol. The formation of dimers and higher order polymers via these hydrophobic contacts may also contribute to the thermostability of this xylanase.
Channel reduction and applications to image processing (2000)

Oftentimes when one is dealing with digital color images it is desired that some sort of image processing be performed on the spatial information. Current methods require that one process each of the channels (also called planes or colors) of an image separately, which increases the number of computations significantly. A novel, to our knowledge, approach to reducing the number of channels in a color image is presented. The channel-reduction process is intended to facilitate such color image-processing situations essentially by the separation of the spectral information from the spatial information, as in a paint-by-numbers picture. In this case the image processing need be applied only to a single channel of data and the color added afterward. With a compression ratio of slightly less than 3:1 the method is not intended to compete with existing compression methods but rather to permit the processing of images in a compressed state.
A Survey of Modern Spam Tools. (2008)

Over the past 5 years, spam sending technology has improved dramatically. Static messages sent opportunistically through misconfigured hosts have evolved into dynamically generated, subtly obfuscated messages sent on a massive scale by special purpose malware. We present a survey of three generations of the most popular spam sending tools, focusing on how they have improved over time. The paper conclude with a case study of a modern spam campaign, showing how the spammer has used randomization to make their messages more difficult to detect by content filters. 1
Space-bandwidth product enhancement of a monostatic, multiaperture infrared image upconversion ladar receiver incorporating periodically poled LiNbO_3 (2002)

We investigate the space-bandwidth product of a ladar system incorporating an upconversion receiver. After illuminating a target with an eye-safe beam, we direct the return into a piece of periodically poled LiNbO3 where it is upconverted into the visible spectrum and detected with a CCD camera. The theoretical and experimental transfer functions are then found. We show that the angular acceptance of the upconversion process severely limits the receiver field of regard for macroscopic coupling optics. This limitation is overcome with a pair of microlens arrays, and a 43% increase in the system's measured space-bandwidth product is demonstrated.
Assessing the Landscape of Payments Fraud (2008)

The Federal Reserve Bank of Chicago will host its eighth payments conference on June 5?6, 2008. The conference will highlight threats to the security of the payments system and explore solutions to those challenges. This article previews issues that will be covered at the conference.
Teacher assessment and teacher change in classroom communication behaviors (1990)

Abstract Typical teacher performance assessment procedures function to select, retain, and certify competent teachers, but they fail to provide diagnostic information for transforming individuals’ teaching practices. Assessments which result in genuine professional growth help teachers (a) identify recurring patterns In Instructional communication and (b) set their own goals for development. A program is described in which content area teachers were encouraged, in accordance with these principles, to change their Instructional styles during classroom discussions of textbook readings. In one illustrative case, a health teacher moved away from a dominant concern about his physical movement in the classroom and toward a concern for eliciting a wider variety of responses among students. An associated model for linking assessment procedures with professional growth delineates five stages: monitor off, monitor on, goal setting, expanding repertoires, and consolidating. At each stage, the model highlights (a) what teachers experience, (b) what teachers understand about classroom interaction, and (c) how assessment helps teachers refine that understanding.
Cross-borehole electromagnetic probing to locate high-contrast anomalies (1979)

Abstract Electromagnetic (EM) probing between boreholes is useful for locating high-contrast geophysical anomalies such as a tunnel. Theoretical and experimental studies of EM field interaction with a tunnel show that minima in the received signal can be used for locating the tunnel. The theoretical studies show that as a transmitter and receiver are lowered in separate boreholes, the minima can be interpreted easily to yield both the lateral and vertical positions of the tunnel. The main mechanism of EM field interaction with the tunnel appears to be diffraction, and the spatial variation of the field strength is affected by the tunnel shape. Frequencies from 10 to 70 MHz were studied to assess the usable frequencies. The field in the receiver borehole was an effective diagnostic when a half-wavelength in the surrounding medium was less than or equal to the diameter of the tunnel. EM probing at two test sites gave the locations of tunnels within 1 ft of the surveyed locations.
Deactivation of bimodal nickel catalyst for steam methane reforming reaction (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDeactivation of bimodal nickel catalyst for steam methane reforming reactionToru Numaguchi and Katsutoshi KikuchiCite this: Ind. Eng. Chem. Res. 1991, 30, 3, 447–453Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/ie00051a003https://doi.org/10.1021/ie00051a003research-articleACS PublicationsRequest reuse permissionsArticle Views285Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries. (1988)

The influence of hypercholesterolemia on the reactivity of coronary arteries was investigated after feeding a high-cholesterol diet to pigs for 9 weeks. After this duration of hypercholesterolemia, the fatty or intimal proliferative changes of atherosclerosis were not yet evident in the coronary arteries by light or electron microscopy. Changes in isometric tension were compared in isolated ring segments of coronary arteries from normal and hypercholesterolemic animals. The endothelium failed to inhibit contractions caused by 5-hydroxytryptamine in coronary arteries from hypercholesterolemic animals, but it did so in normal vessels. In contracted arteries, endothelium-dependent relaxations caused by 5-hydroxytryptamine and substance P were reduced by hypercholesterolemia. In contrast, endothelium-dependent relaxations mediated by norepinephrine acting at alpha 2-adrenoceptors and those caused by the calcium ionophore A23187 were unaffected. Endothelium-independent beta-adrenergic relaxations caused by norepinephrine, as well as those caused by nitroprusside, and papaverine also were unaffected by hypercholesterolemia. The loss of selective endothelial cell receptor-mediated relaxation suggests that it is not the ability of the coronary artery endothelium to elaborate vasodilators, but the initiation of the coronary artery endothelial cell response to 5-hydroxytryptamine and substance P that is affected by hypercholesterolemia. Thus, during hypercholesterolemia, selective endothelial cell dysfunction giving rise to abnormal coronary artery reactivity precedes the onset of coronary artery atherosclerosis.
La cooperación externa de la Unión Europea en materia de lucha contra la droga (1997)

En el Repositorio Institucional Séneca están depositados materiales en formato digital fruto de la producción científica o académica, de esta manera permite almacenar, difundir y preservar información de vital importancia.
Revisiting reuse for approximate query processing (2017)

Visual data exploration tools allow users to quickly gather insights from new datasets. As dataset sizes continue to increase, though, new techniques will be necessary to maintain the interactivity guarantees that these tools require. Approximate query processing (AQP) attempts to tackle this problem and allows systems to return query results at "human speed." However, existing AQP techniques start to break down when confronted with ad hoc queries that target the tails of the distribution. We therefore present an AQP formulation that can provide low-error approximate results at interactive speeds, even for queries over rare subpopulations. In particular, our formulation treats query results as random variables in order to leverage the ample opportunities for result reuse inherent in interactive data exploration. As part of our approach, we apply a variety of optimization techniques that are based on probability theory, including new query rewrite rules and index structures. We implemented these techniques in a prototype system and show that they can achieve interactivity where alternative approaches cannot.
Capillary Column Gas Chromatographic Method for Analysis of Encapsulated Fish Oils and Fish Oil Ethyl Esters: Collaborative Study (1992)

Abstract A gas chromatographic (GC) method using a capillary column for analysis of encapsulated fish oils and ethyl esters was studied collaboratively in 21 laboratories. Each collaborator analyzed 6 soft-gelatin encapsulated samples; 5 were trlacylglycerol oils (one was a blind duplicate), and one was an ethyl ester concentrate of omega-3 (n-3) polyunsaturates. Constituent fatty acids of the oils were converted to methyl esters by base-catalyzed transesterlflcatlon of the oils; any free acids in the oils were esterlfied by subsequent reaction with BF3/CH3OH. The ethyl ester concentrate required no further derlvatlzation. Results were reported as area percentages of 24 analytes of nutritional or biochemical interest. In addition, weights (mg/g sample) of EPA (all-c/s-5,8,11,14,17-elcosapentaenolc acid or 20:5n-3) and DHA (all-c/s- 4,7,10,13,16,19-docosahexaenoic acid or 22:6n-3) were determined through the use of the internal standards, respectively, methyl tricosanoate (23:0) and ethyl 23:0, for the methyl and ethyl esters. The only instrumentation specifically required was a flexible fused silica capillary GC column coated with a bonded polyglycol such as Carbowax-20M, an oxygen scrubber Installed In the carrier gas supply line, and a flame Ionization detector (FID). Most of the collaborators experienced little difficulty In applying the method, and, of 2526 values reported, only 4.3% were identified as outlier values. The reproducibility relative standard deviations (RSDR) compared favorably in most instances with, or were substantially better than, those of 2 earlier collaborative studies of fish oils. Because the variances were homogeneous, standard deviations and relative standard deviations determined on the area percent analyses of the blind duplicate oils were pooled to give the following mean values: sr = 0.15, RSDr = 4.88%, sR = 0.41, and RSDR = 12.91%. Analytes that rarely occur at greater than 0.5% In marine oils (22:0,22:4n-6,22:5n-6,24:0, and 24:1) were not Included in these calculations. The method was adopted first action by AOAC International as an American Oil Chemists' Society (AOCS)-AOAC method.
[Homoharringtonine Induces Apoptosis of K562 Cells through Inhibition of P210(bcr/abl)] (2000)

In this study, the underlying antileukemic mechanisms of homoharringtonine (HHT) were investigated. K562 cell line was used to observe the effects of HHT on the induction of apoptosis and on the expression of the specific chimeric protein P210(bcr/abl), as evaluated by flow cytometric annexin V-PI dual labeling technique and Western blot. The results showed that HHT induced K562 cells to apoptotic death at the concentrations of 5 - 20 ng/ml, and some of the cells became necrotic when exposed to a higher concentration. The amount of P210(bcr/abl) oncoprotein was decreased by approximately 70% when the cells were exposed to HHT for 48 hours, however, that of its partner P145(c-abl) proto-oncoprotein was not affected. It is clear from the study that HHT is an inhibitor of P210(bcr/abl) oncoprotein and therefore promotes the apoptosis of CML cells. It could be promising that HHT be used extensively in the chemotherapy of patients with CML.
Review of Postmenopausal Osteoporosis Pharmacotherapy (2007)

The degradation of bone tissue leading to osteoporosis is often silent and unrecognized until a postmenopausal woman develops a bone fracture. The costs of medical treatment and subsequent changes in the quality of life of a patient are significant, and avoidance via proper nutrition, exercise, and pharmacologic therapy may be the key to decreasing healthcare costs associated with this disease state. A periodic review of current literature is necessary to update the reader of current therapeutic options for the treatment and prevention of osteoporosis. A number of medications exist, and new options are ongoing. Clinicians now have access to antiresorptive and anabolic therapy in addition to lifestyle modification as options for patients. This article consists of a review of established guidelines for screening, diagnosis, and pharmacologic modalities and will provide a comprehensive assessment of therapeutic options.