gebhart/patrepeval huggingface dataset:
Toward a Patient-Centered Approach: Incorporating Principles of Participatory Action Research Into Clinical Studies (2005)

Our approach empowered patients by involving them in the research and in developing solutions for how health care providers, policy makers, and researchers can enhance an integrative approach to cancer care.
Coherent detection of pulsed narrowband terahertz radiation (2005)

We demonstrate the generation and coherent detection of narrowband terahertz radiation using a Q-switched laser pumped optical parametric oscillator as the optical source. Narrowband terahertz radiation is produced using conventional difference frequency mixing and coherently detected via a frequency domain technique that relies on coherent upconversion of the terahertz field combined with optical homodyning to suppress background noise. GaSe crystals are used for both generation and coherent detection processes. Although we provide a proof-of-principle demonstration at 2THz, the infrared radiation may be tuned from the far-infrared through the midinfrared by simply tuning the idler wavelength of the optical parametric oscillator and the orientation of the two crystals.
Independent Resources for Attentional Tracking in the Left and Right Visual Hemifields (2005)

The ability to divide attention enables people to keep track of up to four independently moving objects. We now show that this tracking capacity is independently constrained in the left and right visual fields as if separate tracking systems were engaged, one in each field. Specifically, twice as many targets can be successfully tracked when they are divided between the left and right hemifields as when they are all presented within the same hemifield. This finding places broad constraints on the anatomy and mechanisms of attentive tracking, ruling out a single attentional focus, even one that moves quickly from target to target.
The Vascular Wall as a Source of Stem Cells (2005)

We have characterized the emerging hematopoietic system in the human embryo and fetus. Two embryonic organs, the yolk sac and aorta, support the primary emergence of hematopoietic stem cells (HSCs), but only the latter contributes lymphomyeloid stem cells for definitive, adult-type hematopoiesis. A common feature of intra- and extraembryonic hematopoiesis is that in both locations hematopoietic cells emerge in close vicinity to vascular endothelial cells. We have provided evidence that a population of angiohematopoietic mesodermal stem cells, marked by the expression of flk-1 and the novel BB9/ACE antigen, migrate from the paraaortic splanchnopleura into the ventral part of the aorta, where they give rise to hemogenic endothelial cells and, in turn, hematopoietic cells. HSCs also appear to develop from endothelium in the embryonic liver and fetal bone marrow, albeit at a much lower frequency. This would imply that the organism does not function during its whole life on a stock of hematopoietic stem cells established in the early embryo, as is usually accepted. We next examined whether the vessel wall can contribute stem cells for other cell lineages, primarily in the model of adult skeletal muscle regeneration. By immunohistochemistry and flow cytometry, we documented the existence in skeletal muscle, besides genuine endothelial and myogenic cells, of a subset of satellite cells that coexpress endothelial cell markers. This suggested the existence of a continuum of differentiation from vascular cells to endothelial cells that was confirmed in long-term culture. The regenerating capacity of these cells expressing both myogenic and endothelial markers is being investigated in skeletal and cardiac muscle, and the results are being compared with those generated by satellite cells. Altogether, these results point to a generalized progenitor potential of a subset of endothelial, or endothelium-like, cells in blood vessel walls, in pre- and postnatal life.
USE OF ENZYMES TO ENHANCE OIL RECOVERY DURING AQUEOUS EXTRACTION OF <i>MORINGA OLEIFERA</i> SEED OIL (2006)

ABSTRACT Moringa oleifera seed oil was extracted using four different types of enzymes to obtain the most efficient extraction parameters. The enzymes used were Neutrase 0.8L (neutral protease), Termamyl 120L, type L (α‐amylase), Pectinex Ultra SP‐L (pectinase) and Celluclast 1.5L FG (cellulase). These were used either separately or in combination. Individually, Neutrase was found to be the most effective, followed by Termamyl, Celluclast and Pectinex. A combination of the four enzymes was found to be more effective than used separately, with 74% oil recovery. Percent oil recovery for individual enzymes under optimal conditions and with pH adjusted to the individual enzyme's optimum pH were 71.9, 64.8, 62.6 and 56.5 for Neutrase, Termamyl, Celluclast and Pectinex, respectively. Neutrase, Pectinex and the combination of all the four enzymes at 2% (v/w) were found to perform best at 45C, while Termamyl and Celluclast were best at 60C. The physical and chemical properties of the extracted oils such as iodine value (IV) (66.0–67.2 g iodine/100 g oil), free fatty acid (FFA) content (1.13–1.25 as % oleic acid), complete melting points (MPs) (18.6–19.1C) and viscosities (83.1–85.0 cP) except the color were not significantly affected ( P > 0.05) by the type of enzyme used in the pretreatment of the seed. However, apart from IV and MP, the values for other properties were significantly different (P < 0.05) from those obtained for solvent‐extracted samples.
Zinc induces catalase expression in cultured fetal human retinal pigment epithelial cells (1997)

Our results demonstrate that zinc treatment of RPE cells increases catalase expression and activates the transcription factor Sp1. The results suggest zinc may play a role in the transcriptional regulation of catalase in RPE cells.
Physical Properties of Carbonated Oils (1963)

Abstract The growing interest in the use of CO2 in crude oil recovery increases the need for data on the effect of CO2 on hydrocarbon physical properties. Data are presented on the solubility of CO2 in various dead oils, the swelling changes in CO2 -oil solutions and the effect of CO2 on dead oil viscosity. This later property shows the most pronounced effect, with viscosity reductions up to 98 per cent of the uncarbonated viscosities. An empirical method of estimating the viscosity of carbonated oils is presented. The apparatus and procedures used are described in sufficient detail to allow others to make similar studies. Introduction The effect of dissolved carbon dioxide on the swelling and viscosity reduction of specific hydrocarbon oils has been observed and recorded by a number of investigators. The object of this paper is to offer a means of predicting these effects for crude oils free from natural gas, using the dead state viscosity and gravity of the crude oils. The CO. solubility and swelling of numerous crude oils were determined in a visual cell at various pressure levels. The viscosity of the oils carbonated to various pressure levels was then determined by measuring the pressure drop across a capillary tube. From these data, the physical properties were correlated empirically. The resulting correlations allow the prediction of CO solubility, swelling and viscosity reduction if the dead state gravity and viscosity of the oils are known.
Nanos and Pumilio have critical roles in the development and function of <i>Drosophila</i> germline stem cells (1998)

The zinc-finger protein Nanos and the RNA-binding protein Pumilio act together to repress the translation of maternal hunchback RNA in the posterior of the Drosophila embryo, thereby allowing abdomen formation. nanos RNA is localized to the posterior pole during oogenesis and the posteriorly synthesized Nanos protein is sequestered into the germ cells as they form in the embryo. This maternally provided Nanos protein is present in germ cells throughout embryogenesis. Here we show that maternally deposited Nanos protein is essential for germ cell migration. Lack of zygotic activity of nanos and pumilio has a dramatic effect on germline development of homozygous females. Given the coordinate function of nanos and pumilio in embryonic patterning, we analyzed the role of these genes in oogenesis. We find that both genes act in the germline. Although the nanos and pumilio ovarian phenotypes have similarities and both genes ultimately affect germline stem cell development, the focus of these phenotypes appears to be different. While pumilio mutant ovaries fail to maintain stem cells and all germline cells differentiate into egg chambers, the focus of nanos function seems to lie in the differentiation of the stem cell progeny, the cystoblast. Consistent with the model that nanos and pumilio have different phenotypic foci during oogenesis, we detect high levels of Pumilio protein in the germline stem cells and high levels of Nanos in the dividing cystoblasts. We therefore suggest that, in contrast to embryonic patterning, Nanos and Pumilio may interact with different partners in the germline.
Clay–starch composites and their application in papermaking (2006)

Abstract Clay–starch composites with different aggregate sizes and starch to clay ratios were prepared by a simple precipitation method. The aggregates of the composites were used as fillers to improve the paper properties. The experimental results showed that the paper strengths increased more than 100% for starch‐modified clay compared to untreated clay at 20–30% clay loading. The increase in paper strengths of clay–starch composite‐filled handsheets was mainly due to two reasons, i.e., the relatively large aggregate size and the improved internal bonding. The optical properties compared at same mechanical strength were also improved. The water solubility of starch in the clay–starch composite was less than 3% at 50°C for 30 min, and it could be further reduced by adding crosslinker. Bonding sites between composite and fiber were investigated by scanning electron microscope. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 1032–1038, 2006
Design and calibration of a compact multi-frequency EIT system for acute stroke imaging (2006)

A new, compact UCLH Mk 2.5 EIT system has been developed and calibrated for EIT imaging of the head. Improvements include increased input and output impedances, increased bandwidth and improved CMRR (80 dB) and linearity over frequencies and load (0.2% on a single channel, +/-0.7% on a saline tank over 20 Hz-256 kHz and 10-65 Omega). The accuracy of the system is sufficient to image severe acute stroke according to the specification from recent detailed anatomical modelling (Horesh et al 2005 3rd European Medical and Biological Engineering Conference EMBEC'05). A preliminary human study has validated the main specifications of the modelling, the range of trans-impedance from the head (8-70 Omega) using a 32 electrode, 258 combination protocol and contact impedances of 300 Omega to 2.7 kOmega over 20 Hz to 256 kHz.
Component processes in free-viewing visual search: Insights from fixation-aligned pupillary response averaging (2020)

Pupil size changes during a visual search may reflect cognitive processes, such as effort and memory accumulation, but methodological confounds and the general lack of literature in this area leave the reliability of findings open to question. We used a novel synthesis of experimental methods and averaging techniques to explore how cognitive processing unfolds during free-viewing visual search for multiple targets. Twenty-seven participants completed 152 searches across two separate 1-hour sessions. The number of targets present (Targets: 0, 1, 2, and 3) in each trial was the main manipulation and the task was to "find all of the targets" and report the total via mouse-click at the end of the trial. Search time lasted for 10 seconds or until the participant purported to have found all of the targets, in which case they could terminate the search via keypress. Whole-trial pupil analysis revealed a significant effect of button pressing as well as a significant main effect of targets for trials that were not self-terminated via button press. Fixation-aligned pupil responses revealed transient modulations in pupil size following initial fixations on targets but not distractors and refixations on both targets and distractors. Owing to rigorous control over experimental confounds and a detailed analysis and correction of eye-movement-related measurement error, we confidently discuss these findings in terms of task-related processing and underlying brain activity.
Research progress of Coben cephalometric analysis (2011)

To a large extent,good orthodontic treatment depends on the specific diagnosis and treatment,and then we can develop the right plan.Cephalometric analysis is an important auxiliary measure for clinical diagnosis and analysis of orthodontic cases.In this article,Coben analysis status and progress are summarized.
Multi-modal Topic Modelling and Summarization with Dense Block Detection: A Review (2017)

There has been incredible growth of events over the internet in recent years. Google has become the giant source of knowledge for any event which has happened or happening over the internet. Some networking sites such as face book, micro blogging sites such as twitter are evolved with time and became the highly used sites over the internet. Various E-commerce websites such as Amazon, Ebay, Flipkart etc are the widely used sites for online shopping. These sites generates large amount of text data. In association with text data some images are also uploaded over the internet on these sites. To model this huge amount of multi-modal data having both textual and visual contents multi-modal topic model for summarization, analysis is suggested in this paper. While dealing with multimodality, study of semantic relationship between the images and text data is crucial part. This model also helps to study semantic relationship between them effectively. Topics which are trending, popular over the world can be seen on Social sites as well as micro blogging sites. In online shopping sites fake reviews, advertises, spam spreading information is posted. For summarizing and analyzing the data we have taken the dataset containing reviews and product information from Amazon, one of the leading E-commerce sites. This information is used for modeling topic on sites with summarization and analysis. In this paper detailed study of other previous methods is also shown.
The human platelet ADP receptor activates Gi2 proteins (1995)

We have previously shown that platelet ADP receptors are coupled to G-proteins by measuring the binding of [35S]guanosine-5'-[gamma-thio]triphosphate ([35S]GTP gamma S) to human platelet membranes stimulated with ADP. In order to identify the activated G-proteins, we used an approach which combines photolabelling of receptor-activated G-proteins with 4-azidoanilido-[alpha-32P]GTP and immunoprecipitation of the G-protein alpha-subunits with subtype-specific antibodies. Stimulation of human platelet membranes with ADP resulted in an increase in 4-azidoanilido-[alpha-32P]GTP incorporation into the immunoprecipitates of G alpha i but not of G alpha q proteins, whereas stimulation with the thromboxane analogue U46619 resulted in an increase in 4-azidoanilido-[alpha-32P]GTP incorporation into the immunoprecipitates of G alpha q but not of G alpha i proteins, and thrombin activated both G-proteins. This effect of ADP was concentration dependent and inhibited by the class P2 purinoceptor (P2T) antagonist ATP. Using specific antisera against subtypes of Gi proteins, we found that ADP stimulated labelling of the G alpha 12 immunoprecipitate, but not of the G alpha 13 precipitate. G alpha i1 was not detectable by immunoblotting of platelet membrane proteins. These data suggest that ADP inhibits cAMP formation by activation of G alpha 12 proteins and add evidence in support of the hypothesis that human platelet ADP receptors do not activate PLC through Gq activation.
Registration and integration of multiple range images for 3-D model construction (1996)

Registration and integration of measured data of real objects are becoming important in 3D modeling for computer graphics and computer-aided design. We propose a new algorithm of registration and integration of multiple range images for producing a geometric object surface model. The registration algorithm determines a set of rigid motion parameters that register a range image to a given mesh-based geometric model. The algorithm is an integration of the iterative closest point algorithm with the least median of squares estimator. After registration, points in the input range are classified into inliers and outliers according to registration errors between each data point and the model. The outliers are appended to the surface model to be used by registration with the following range images. The parts classified as inlier by at least one registration result is segmented out to be integrated. This process consisting of registration and integration is iterated until all views are integrated. We successfully experimented with the proposed method on real range image sequences taken by a rangefinder. The method does not need any preliminary processes.
A reporter allele for investigating connexin 26 gene expression in the mouse brain (2003)

A variety of connexins are expressed in the diverse cell types of the central nervous system and are thought to regulate some of the functional properties exhibited by immature and mature cells. A proper understanding of the role of specific connexins in these processes requires an unambiguous characterization of their spatial and temporal pattern of expression. In order to define the cellular distribution of connexin 26 (Cx26) in the mouse we have generated a reporter allele (Cx26lacZ) by genetically manipulating the locus so that the beta-galactosidase (lacZ) gene is expressed from the endogenous Cx26 promoter. This modification decreased expression from the allele and resulted in embryonic lethality for the Cx26lacZ/lacZ genotype in accordance with previous studies on Cx26 knock-out animals indicating that Cx26-containing gap junctions are necessary for embryonic development. Despite the lower than expected transcript levels, the amount of lacZ protein produced in heterozygous mice was sufficient to label tissues known to contain Cx26, such as liver, kidney, skin, cochlea, small intestine, placenta and thyroid gland. In the embryonic and mature central nervous system, however, lacZ was restricted to meningeal cells and could not be detected in either neurons or glia. The absence of Cx26 mRNA in these cells could also be confirmed by reverse transcription-polymerase chain reaction and in situ hybridization. Our experiments indicate that the Cx26lacZ mouse line can be used as a reporter of Cx26 gene expression and suggest that Cx26, contrary to previous reports, is restricted to the meninges in both embryonic and adult brain.
High-Resolution Spectroscopy with Reciprocal-Space Analysis: Application to Isotopically Pure Si (2000)

We discuss a new Fourier-transform approach that has recently been developed to optimize the determination of critical point parameters in optical spectra. In this approach, segments of direct (energy or frequency) space spectra are Fourier transformed into reciprocal (Fourier-inverse) space, and the endpoint-discontinuity artifacts that result are eliminated by subtracting corresponding coefficients of low-order Legendre polynomials determined by least-squares fitting these coefficients to the transformed data in the white-noise region. We apply this approach to determine the extremely small effect of isotopic mass on the energy of the E1 critical point of crystalline Si from low-temperature spectroscopic ellipsometric data.
Low-frequency characterization of quantum tunneling in flux qubits (2002)

We propose to investigate flux qubits by the impedance measurement technique (IMT), currently used to determine the current-phase relation in Josephson junctions. We analyze in detail the case of a high-quality tank circuit coupled to a persistent-current qubit, to which the IMT was successfully applied in the classical regime. It is shown that the low-frequency IMT can give considerable information about the level anticrossing, in particular the value of the tunneling amplitude. An interesting difference exists between applying the ac bias directly to the tank and indirectly via the qubit. In the latter case, a convenient way to find the degeneracy point in situ is described. Our design only involves existing technology, and its noise tolerance is quantitatively estimated to be realistic.
Advances in Medical Devices and Medical Electronics (2012)

Medical devices and medical electronics are areas that had little to offer 100 years ago. However, there were three important existing technologies that led to many further developments over the following 100 years. These are the stethoscope, electrocardiography, and X-ray medical imaging. Although these technologies had been described and were available to some extent when the Proceedings of the IEEE pages first appeared, they had yet to achieve the widespread use that they have today. The stethoscope is the oldest of these, and it helped physicians to hear sounds of the body and relate them to functioning and malfunctioning organs. The early use of the stethoscope by physicians was more of an art than a science, but as the Proceedings matured, so did this technology. Engineers were able to make this a more quantitative process by graphically displaying the sounds and ultimately using techniques such as voiceprint analysis to assist the physician in diagnosis and monitoring of treatment. The electrocardiograph had been invented a few years prior to the appearance of the Proceedings, but the apparatus was awkward to use, especially for sick people, and was considered more of an oddity than a viable medical technology 100 years ago. Today, it and devices derived from it such as cardiac patient monitors are important parts of our healthcare system. Similarly, X-rays represented a new technology 100 years ago, but unlike electrocardiography physicians immediately saw the value of this technology and quickly adopted it. Many improvements have been made to the basic technology over the last 100 years culminating in computer tomography and complex image processing. Other devices to create high-quality and 3-D medical images have also been developed in recent years to make medical imaging a very important aspect of clinical care today. Looking to the future is always a difficult task, but it is clear that the electronic health record will play an important role in consolidating the information from various medical devices as well as providing readily available data on patients wherever it might be needed. Future medical devices will need to not only address the problems of diagnostic and therapeutic medicine but also be capable of addressing important societal problems such as worldwide disparities in the availability of medical care, continually rising healthcare costs, and healthcare for travel beyond Earth. The next 100 years promises to be even more exciting than the last from the perspective of medical devices and medical electronics.