gebhart/patrepeval huggingface dataset:
Survey of American Foreign Relations. Prepared under the direction of Charles P. Howland. New Haven: Yale University Press, 1930. pp. xvii, 541. Index. $5.00. (1931)

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Reverse phase high performance liquid chromatographic determination of Baygon in water (1983)

A simple analytical procedure for determination of Baygon in water is described. The Baygon residues are extracted on a C18 SEP-PAK cartridge and subsequently analyzed by reverse phase high performance liquid chromatography using ultraviolet detection at 272 nm. Water samples spiked with Baygon are found to give greater than 90 percent recoveries. Concentration levels as low as 20 ppb can be easily detected by this method.
Design and Analysis of Vibration Test Fixtures for Payloads (2010)

The project addresses the design principles and performs finite element analysis (FEA) of vibration fixtures used for testing of space payloads at MIT Lincoln Laboratory. A review of standards that govern vibration testing of space and general payloads is presented. A set of principles and a tutorial for the design of vibration test fixtures is presented. The validation of the design principles is achieved through FEA of a vibration test fixture that involves a structure with panels, rails and support blocks. The FEA code PATRAN/NASTRAN is used and analysis of the three-dimensional computational results leads to design modifications that involve an added third panel. The redesigned fixture has increased stiffness, as well as reduced stress and displacement of its rails.
Effects of monoclonal antibodies that block transferrin receptor function on the in vivo growth of a syngeneic murine leukemia. (1987)

The ability of monoclonal antibodies (MAbs) against the murine transferrin receptor to inhibit the growth of transplanted syngeneic AKR/J SL-2 leukemic cells has been investigated. Two rat IgM antibodies, RI7 208 and REM 17.2, which both block transferrin receptor function, inhibited the growth of SL-2 leukemic cells in vitro at concentrations of 5-10 micrograms per ml. However, RI7 208 was more effective than REM 17.2 in prolonging survival of tumor-bearing mice. The antitumor effects of RI7 208 MAb were dependent on both the antibody dose and number of leukemic cells inoculated. The serum clearance of [75Se]methionine-labeled RI7 208 and REM 17.2 antibodies was similar and consisted of an initial rapid phase over the first 2 days followed by a slower phase. A single dose of 2 mg of antibody maintained a serum MAb concentration (greater than 10 micrograms/ml) sufficient to inhibit SL-2 leukemic cell growth in vitro for 2-3 days. The liver, kidney, and spleen were the major sites at which each of the antibodies accumulated regardless of whether trace or saturating amounts of antibody were administered. The specific activity of antibody found in s.c. SL-2 tumors was about 2-fold less than that of liver. It was shown that multiple doses of R17 208 MAb administered on a schedule aimed at maintaining a therapeutic serum level of MAb for 1-3 weeks were more effective than a single dose. Further, administration of RI7 208 MAb, in combination with the anti-Thy-1.1 MAb 19E12, was more effective than either antibody alone. SL-2 mutant cells were selected that were resistant to growth inhibitory effects of RI7 208 in vitro. The effects of RI7 208 MAb on the growth of these mutant cells in vivo suggests the major mechanism by which the MAb inhibits SL-2 tumor growth is by directly blocking receptor function. Acute toxicity associated with administration of the MAb was minimal. However, assays of myeloid and erythroid colony-forming units in bone marrow and spleen of mice given multiple doses of RI7 208 showed a depression of stem cell activity in bone marrow and elevated numbers of erythroid and cellular colony-forming units in the spleen.
VADER: Visualization and Analytics for Distributed Energy Resources (2017)

Enabling deep penetration of distributed energy resources (DERs) requires comprehensive monitoring and control of the distribution network. Increasing observability beyond the substation and extending it to the edge of the grid is required to achieve this goal. The growing availability of data from measurements from inverters, smart meters, EV chargers, smart thermostats and other devices provides an opportunity to address this problem. Integration of these new data poses many challenges since not all devices are connected to the traditional supervisory control and data acquisition (SCADA) networks and can be novel types of information, collected at various sampling rates and with potentially missing values. Visualization and analytics for distributed energy resources (VADER) system and workflow is introduced as an approach and platform to fuse these different streams of data from utilities and third parties to enable comprehensive situational awareness, including scenario analysis and system state estimation. The system leverages modern large scale computing platforms, machine learning and data analytics and can be used alongside traditional advanced distribution management system (ADMS) systems to provide improved insights for distribution system management in the presence of DERs.
NKp30 (NCR3) is a Pseudogene in 12 Inbred and Wild Mouse Strains, but an Expressed Gene in Mus caroli (2005)

Ancient duplications and rearrangements of protein-coding segments have resulted in complex gene family relationships. As a result, gene products may acquire new specificities, altered recognition properties, modified functions, and even loss of functionality. The natural cytotoxicity receptor (NCR) family are natural killer (NK)–activating receptors whose members are NKp46 (NCR1), NKp44 (NCR2), and NKp30 (NCR3). The NCR proteins are putative immunoglobulin superfamily members whose ligands are unknown. The NKp46 gene is present and expressed in human and mouse, NKp44 is only present and expressed in human, and NKp30 is present and expressed in human but is a nonexpressed pseudogene in mouse. By searching databases we have detected alternatively spliced forms of the three NCR members. In addition, we have shown by reverse transcription–polymerase chain reaction (RT-PCR) analysis that the human NKp30 gene presents differential expression patterns in tissues. However, no expressed sequence tags (ESTs) are detected for mouse NKp30, and the genomic sequence contains two premature stop codons, which would encode a severely truncated nonfunctional protein. We have sequenced genomic DNA from 13 mouse inbred and wild strains and discovered that NKp30 is a pseudogene in every mouse strain sequenced except Mus caroli where two single nucleotide polymorphisms (SNPs) abolished the premature stop codons. We observed that the laboratory-inbred strains are, for the exonic sequences, genetically identical, except Mus m. musculus C3H. The Mus musculus strains only have a few SNPs, but the rest of the Mus strains have accumulated gradually several SNPs, mainly in the functional immunoglobulin and intracellular domains. RT-PCR analysis performed on RNA from M. caroli tissue samples identified two transcripts, one of which would encode a putative soluble NKp30 protein, also detected in rat but not in human. We have observed that the intracellular domains of NKp30 (and NKp46) are not conserved among the different species, with the most striking difference when comparing human against mouse and rat. The NKp44 gene is only found in human and shows three different splice forms varying in their "stalk" and intracellular domains. Searching for NKp44 orthologs, we found similarity to ESTs from a novel rodent TREM family member, which we termed TREM6, and not to any possible NKp44 ortholog.
Design and study of a novel hyper-redundant manipulator (2003)

Summary A novel hyper-redundant manipulator named RT1 is presented in this paper. The key feature of RT1 is that all degrees of freedom (DOF) are actuated with only one motor, via specially designed hinge bar universal joints. The mechanism of RT1 which includes a special hinge bar universal joint, bend structure and motion diversion structure is described. RT1 is a discrete manipulator; the discrete working space is described, and the parameter optimization for kinematical redundancy resolution is also studied. In selecting the unit increment of joints angles as an optimizing parameter, the criterion used is to alter the design parameter as little as possible during the manipulator’s motion from the initial to the expected position.
Algorithms to Test Ray-Triangle Intersection. Comparative Study (2001)

In this article we present an algorithm to determine the intersection between rays and triangles based on\nthe idea of the study of signs with respect to triangles. One of the advantages of this approach is its\nrobustness due to its lack of trigonometric operations or complex divisions which might alter the result of\nthe calculations. The algorithm is similar (or even better) in time to other existing algorithms, but it is\nbased exclusively on the study of signs, so that the results obtained are more precise. A comparative study\nof times between the algorithm and other similar algorithms is presented.
Recombinant Human Epidermal Growth Factor (rhEGF) Protects Radiation-Induced Intestine Injury in Murine System (2010)

This study was to investigate whether rhEGF protects radiation induced intestine injury without compromising antitumor effect of radiation in murine system. A radiation induced intestinal injury model was established in mice by whole body irradiation. Using this model, 4 groups were set; control, rhEGF (100 µg/kg intraperitoneally), radiation (10 Gy), and a combination (rhEGF and radiation). The level of apoptosis and proliferation were analyzed by TUNEL assay and proliferation cell nuclear antigen (PCNA) immunohistochemical staining, respectively, as well as observation of survival and body weight change. A tumor growth delay assay was performed using murine syngeneic tumors; one radioresistant tumor, HCa-I and one radiosensitive tumor, MCa-K. In the radiation induced intestinal injury model, the 10 Gy group had significantly more weight loss with less number of crypt cells and higher apoptosis than the 8 Gy group. Using 10 Gy model, radioprotective effect of rhEGF was tested. Addition of rhEGF improved not only the body weight loss but also survival following radiation. It also induced suppression of apoptosis as well as increase of PCNA expression and recovery of villi. rhEGF did not enhance the tumor growth after radiation exposure in the tested tumors. These findings suggest that combination of exogenous rhEGF and radiation can be a new anticancer strategy by protecting radiation-induced intestinal injury without alleviating antitumor effect of radiation.
Distributed Differentially Private Stochastic Gradient Descent: An Empirical Study (2016)

In fault-prone large-scale distributed environments stochastic gradient descent (SGD) is a popular approach to implement machine learning algorithms. Data privacy is a key concern in such environments, which is often addressed within the framework of differential privacy. The output quality of differentially private SGD implementations as a function of design choices has not yet been thoroughly evaluated. In this study, we examine this problem experimentally. We assume that every data record is stored by an independent node, which is a typical setup in networks of mobile devices or Internet of things (IoT) applications. In this model we identify a set of possible distributed differentially private SGD implementations. In these implementations all the sensitive computations are strictly local, and any public information is protected by differentially private mechanisms. This means that personal information can leak only if the corresponding node is directly compromised. We then perform a set of experiments to evaluate these implementations over several machine learning problems with both logistic regression and support vector machine (SVM) loss functions. Depending on the parameter setting and the choice of the algorithm, the performance of the noise-free algorithm can be closely approximated by differentially private variants.
Tivanisiran, a novel siRNA for the treatment of dry eye disease (2018)

Dry eye disease (DED) is characterized by an alteration of the tear film with ocular inflammation and neurosensory abnormalities. The main clinical signs of this condition are tear instability and ocular damage. Although DED has gained significant attention in the past few years, limited prescription treatment options are available for patients. Areas covered: The current manuscript summarizes the pre-clinical and clinical development of tivanisiran, a novel small interfering oligonucleotide of RNA (siRNA) used for the treatment of DED. Tivanisiran was designed to silence Transient Receptor Potential Vanilloid 1 (TRPV1); herein the chemistry and mechanism of action of this new compound is also described. Expert opinion: Drugs currently on the market mostly target the inflammatory component of the disease and show only partial efficacy. New compounds addressing other aspects of the disease would provide significant advantages and contribute to a more personalized treatment of the disease. Tivanisiran has been designed to reduce ocular discomfort and pain, and was shown to improve ocular hyperemia and tear quality in human and animal models. Consequently, if the results of the ongoing and future clinical trials meet their study endpoints, tivanisiran could be submitted to obtain approval for the treatment of DED.
A 64 Gb/s Low-Power Transceiver for Short-Reach PAM-4 Electrical Links in 28-nm FDSOI CMOS (2018)

A four-level pulse-amplitude modulation (PAM-4) transceiver operating up to 64 Gb/s in 28-nm CMOS fully depleted silicon-on-insulator (FDSOI) for short-reach electrical links is presented. The receiver equalization relies on a flexible continuous-time linear equalizer (CTLE), providing a very accurate channel inversion through a transfer function that can be optimally adapted at low frequency, mid-frequency, and high frequency independently. The CTLE meets the performance requirements of CEI-56G-VSR without requiring the decision feedback equalizer (DFE) implementation. As a result, timing constraints for comparators in data and edge sampling paths may be relaxed by using track-and-hold (T&H) stages, saving power consumption. At the maximum speed, the receiver draws 180 mA from 1-V supply, corresponding to 2.8 mW/Gb/s only. The transmitter embeds a flexible feed-forward equalizer (FFE) which can be reconfigured to comply with legacy standards. A comparison between current-mode (CM) and voltage-mode (VM) TX drivers is proposed, proving through experiments that the latter yields larger PAM-4 eye openings, thanks to the intrinsically higher speed. The full transceiver (TX, RX, and clock generation) operates from 16 to 64 Gb/s in PAM-4 and 8 to 32 Gb/s in non-return-to-zero (NRZ), and supports 2× and 4× oversampling to reduce data rate down to 2 Gb/s. A TX-to-RX link at 64 Gb/s, across a 16.8-dB-loss channel, reaches 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> minimum bit-error rate (BER) and 0.19-UI horizontal eye opening at BER = 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> , with 5.02 mW/Gb/s power dissipation.
SIGSEQ: a computer program for predicting signal sequence cleavage sites (1988)

Journal Article SIGSEQ: a computer program for predicting signal sequence cleavage sites Get access A. M. Popowicz, A. M. Popowicz Rockefeller University, Computing Services1230 York Avenue, New York, NY 10021, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar P. F. Dash P. F. Dash Rockefeller University, Computing Services1230 York Avenue, New York, NY 10021, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Bioinformatics, Volume 4, Issue 3, August 1988, Pages 405–406, https://doi.org/10.1093/bioinformatics/4.3.405 Published: 01 August 1988
The influence of the surface structure of polyaniline films on the adsorption of influenza A viruses and antibodies to them (2016)

Adsorption of influenza A viruses and their antibodies on golden surfaces, thin films of polyaniline and polyaniline complex with polysulfonic acids, has been studied. The composition of interpolymer complexes was found to influence both the surface relief of synthesized films and the adsorption efficiency. Moreover, it has been shown that the adsorption of bio-objects increased with a growth of surface roughness of the polymer coatings. It has been suggested that this effect was caused by an tight contact between the studied bioobjects and the surface relief elements of close size. In addition, the surface protuberances can act as active centers of adsorption due to their larger accessibility. The results testify to the potential of application of films composed of interpolymer polyaniline complexes with a developed surface relief as a basis to prepare biosensors that are sensitive to viruses and antibodies.
4-Cyanobenzaldehyde isonicotinoylhydrazone monohydrate: a three-dimensional hydrogen-bonded framework structure (2007)

In the title compound, C(14)H(10)N(4)O.H(2)O, the molecular components are linked into a three-dimensional framework by three hydrogen bonds, one each of the O-H...O, O-H...N and N-H...O types, weakly augmented by two C-H...O hydrogen bonds.
Mode of action of a new type of UDP-glucose analog against herpesvirus replication (1988)

The mode of action of a new type of UDP-glucose analog against herpes simplex virus type 1 (HSV-1) replication was examined. The analog showed good selectivity and potent activity. At 10 micrograms/ml, P-536 inhibited the formation of infectious HSV-1 by more than 90%, whereas at 100 micrograms/ml it had no cytotoxic effects, as evidenced by phase-contrast microscopy. P-536 showed a wide spectrum of action and was active against HSV-1, adenovirus type 5, vaccinia virus, poliovirus type 1, encephalomyocarditis virus, vesicular stomatitis virus, influenza virus, and measles virus, irrespective of whether these viruses have lipidic envelopes or not. P-536 clearly inhibited protein glycosylation if added at the time when late viral proteins were being synthesized. Moreover, it also interfered with the synthesis of nucleic acids and the phosphorylation of nucleosides. If P-536 was present from the beginning of infection, HSV-1 replication was blocked at an early step and the infected cells continued to synthesize cellular proteins for long periods.
Low-Operation-Voltage Comb-Shaped Field Emitter Array (1992)

The dependence of emission properties on the structure of comb-shaped lateral field emitter arrays (FEAs) has been investigated. The present FEA consists of an array of rectangular emitter tips with 3 µm-wide edges and a gate self-aligned to the emitter. It was found from experimental results that the ratio of pitch (= p ) to edge width (= a ) of the array had a strong influence on the emission properties, and that p / a ∼3 was an optimum ratio to lower the operation voltage. Under this condition, an emission current of 1.4 µA/tip was obtained at a gate voltage of 110 V.
Energy Efficiency of Adaptive Transmission for MIMO-OFDM Systems over Polarization-Sensitive Channels (2014)

The employ an adaptive space-polarization MIMO test bed to investigate the energy efficiency of different adaptive precoded MIMO architectures, including co-polarized MIMO (CP-MIMO), dual-polarized MIMO (DP-MIMO), and space-polarization MIMO (SP-MIMO) architectures. The analysis quantifies the relative energy efficiencies and achievable rates when precoding is used. The performance is investigated over different polarization-sensitive channels and includes the impact of packet erasures. The adaptive precoding analysis relies on accurate and repeatable physical channel realizations from the test bed, which demands sophisticated hardware and test bed calibration procedures. Examples results from the test bed are presented, illustrating the relative energy efficiencies among the different MIMO architectures.
[Isolation, cultivation and identification of neural stem cell from human embryonic CNS]. (2002)

This is a study on the cultivation condition in vitro and differentiation of neural stem cells from human embryonic brain in order to find a way to get purified multipotential neural stem cells. The single cells was derived from the three-month embryonic brain digested with trypsin, some cells was frozen, the other cells were expanded with EGF and bFGF, the single-cell-clone was obtained by the way of limited dilution, and the serum was used to induce the cells differentiation. The cells were detected with the method of immunohistochemistry. The results showed that a lot of neurospheres could be seen in the presence of mitogens (both EGF and bFGF) and serum could induce neural stem cells to differentiate into neurons, astrocytes, and oligodendrocytes. These indicate that the survival and proliferation of neural stem cells rely on the cooperation of EGF and bFGF. The neural stem cells can also be harvested from the frozen cells.
Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin (2016)

Developmental transcription programs are epigenetically regulated by the competing actions of polycomb and trithorax (TrxG) protein complexes, which repress and activate genes, respectively. Ewing sarcoma is a developmental tumor that is associated with widespread de-regulation of developmental transcription programs, including HOX programs. Posterior HOXD genes are abnormally over-expressed by Ewing sarcoma and HOXD13, in particular, contributes to the tumorigenic phenotype. In MLL1 fusion-driven leukemia, aberrant activation of HOXA genes is epigenetically mediated by the TrxG complex and HOXA gene expression and leukemogenesis are critically dependent on the protein-protein interaction between the TrxG proteins MLL1 and menin. Based on these data, we investigated whether posterior HOXD gene activation and Ewing sarcoma tumorigenicity are similarly mediated by and dependent on MLL1 and/or menin. Our findings demonstrate that Ewing sarcomas express high levels of both MLL1 and menin and that continued expression of both proteins is required for maintenance of tumorigenicity. In addition, exposure of Ewing sarcoma cells to MI-503, an inhibitor of the MLL1-menin protein-protein interaction developed for MLL1-fusion driven leukemia, leads to loss of tumorigenicity and down-regulated expression of the posterior HOXD gene cluster. Together these data demonstrate an essential role for MLL1 and menin in mediating tumor maintenance and posterior HOXD gene activation in Ewing sarcoma. A critical dependency of these tumors on the MLL1-menin interaction presents a potentially novel therapeutic target.