gebhart/patrepeval huggingface dataset:
Leprechaunism: an inherited defect in a high-affinity insulin receptor. (1985)

We examined in vivo oral glucose tolerance tests and in vitro insulin binding, cellular response, and insulin-receptor structure of fibroblasts cultured from the skin of a patient with leprechaun syndrome and her parents. In response to oral glucose, the proband exhibited marked hyperinsulinism (maximum plasma insulin = 4,120 microU/ml), the father had mild hyperinsulinism (maximum plasma insulin = 240 microU/ml), and the mother was normal. [125I]insulin binding to monolayers of intact fibroblasts demonstrated complex kinetics that were interpreted using a two-receptor model. Normal high-affinity binding had an apparent KA of 1.6 X 10(10)/molar with 1,100 sites/cell. The proposed low-affinity state receptor had an apparent KA of 6.8 X 10(7)/molar with approximately 30,000 sites/cell. Insulin binding to the proband's cells had no high-affinity binding but had normal low-affinity binding. Cells from the mother had 60%, and cells from the father, 2%, of control insulin binding to the high-affinity receptor, but normal, low-affinity site binding. Two different, insulin-stimulable responses were evaluated under experimental conditions identical with those used for insulin binding. Insulin stimulation of 2-methylaminoisobutyric acid uptake occurred with half-maximal responses between 25 and 50 ng/ml insulin. This response was similar in cells from controls and the patient. By contrast, the uptake and phosphorylation of 2-deoxy-D-glucose was stimulated at half-maximal insulin concentrations between 1 and 10 ng/ml in control cells but was not significantly increased in the proband's cells until 1,000 ng/ml concentrations of insulin were attained. In affinity crosslinking experiments, [125I]insulin was covalently bound to insulin receptors of fibroblast membranes using disuccinimidylsuberate. [125I]insulin specifically bound to 125,000 dalton monomeric subunits and 250,000 dalton dimers. In control cells, the ratio of monomer to dimer was approximately one, but significantly fewer dimers were crosslinked in insulin receptors from the patient's cells. We conclude that in this family two different recessive mutations impair high-affinity insulin-receptor binding and that the proband with leprechaunism is a compound heterozygote for these mutations. The two mutations produced structural changes in the receptor that altered subunit interactions and loss of high-affinity binding and cellular responsivity.
Intrinsic viscosity dependence on polymer molecular weight and fluid temperature (2003)

Abstract Experimental solution intrinsic viscosity responses to temperature and polymer molecular weight variations were used to test the modeling capability of a simplified intrinsic viscosity equation. The multiple linear equation contains three parameters that are related to the thermodynamic properties of a polymer solution. Simple linear regression was used to produce an intrinsic viscosity equation containing unique fitted parameters for each of three solutions. These parameters describe the polymer coil size at unperturbed conditions and the polymer coil expansion capabilities of the solvent as a function of fluid temperature and molecular weight. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 2831–2835, 2003
High‐throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth (2013)

MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression post-transcriptionally. We have characterized the role of miRNAs in regulating the human epidermal growth factor receptor 2 (HER2)-pathway in breast cancer. We performed miRNA gain-of-function assays by screening two HER2 amplified cell lines (KPL-4 and JIMT-1) with a miRNA mimic library consisting of 810 human miRNAs. The levels of HER2, phospho-AKT, phospho-ERK1/2, cell proliferation (Ki67) and apoptosis (cPARP) were analyzed with reverse-phase protein arrays. Rank product analyses identified 38 miRNAs (q < 0.05) as inhibitors of HER2 signaling and cell growth, the most effective being miR-491-5p, miR-634, miR-637 and miR-342-5p. We also characterized miRNAs directly targeting HER2 and identified seven novel miRNAs (miR-552, miR-541, miR-193a-5p, miR-453, miR-134, miR-498, and miR-331-3p) as direct regulators of the HER2 3'UTR. We demonstrated the clinical relevance of the miRNAs and identified miR-342-5p and miR-744* as significantly down-regulated in HER2-positive breast tumors as compared to HER2-negative tumors from two cohorts of breast cancer patients (101 and 1302 cases). miR-342-5p specifically inhibited HER2-positive cell growth, as it had no effect on the growth of HER2-negative control cells in vitro. Furthermore, higher expression of miR-342-5p was associated with better survival in both breast cancer patient cohorts. In conclusion, we have identified miRNAs which are efficient negative regulators of the HER2 pathway that may play a role in vivo during breast cancer progression. These results give mechanistic insights in HER2 regulation which may open potential new strategies towards prevention and therapeutic inhibition of HER2-positive breast cancer.
Dynamic spectral power equalization using micro-opto-mechanics (1998)

We present a voltage-controlled spectral attenuator for gain shaping and power equalization in wavelength division multiplexed single-mode fiber systems. A micro-opto-mechanical modulator array, where electrostatic deflection of a silicon nitride quarter-wave dielectric layer suspended over a silicon substrate creates a column of variable reflectivity mirrors, is packaged using bulk optics and a diffraction grating to disperse the input spectrum across the device and collect the reflected light into a separate output fiber. The packaged component has 9-dB excess loss, 20-dB dynamic range and 10-μs response. We demonstrate equalization of the amplified spontaneous emission spectrum from an erbium-doped fiber amplifier and of individual laser signals with 10-dB initial variation to less than 0.5-dB variation over a 24-nm passband-free spectrum.
Relative effects of weight loss and dietary fat modification on serum lipid levels in the dietary treatment of obesity. (1993)

The independent effects of weight loss and dietary fat modification on serum lipids were investigated in two groups of healthy moderately obese men and women. In one group (sequential group, n = 19), a weight-stable low-fat, low-saturated-fat diet (Low-Sat) was given for 7 weeks (= dietary modification), followed by a 4.2 MJ/day deficit Low-Sat diet for 13 weeks (i.e., weight loss alone). Another group (simultaneous group, n = 22) received a 4.2 MJ/day deficit Low-Sat diet for 13 weeks (i.e., weight loss+dietary fat modification). Each group was subject to an initial weight-stable high-fat, high-saturated fat diet for 3 weeks and a final weight stable Low-Sat diet for 3 weeks. Both groups lost similar amounts of body weight, about 13 kg, and had similar overall changes in total cholesterol, low density lipoprotein (LDL), cholesterol, high density lipoprotein (HDL) cholesterol, the HDL/LDL ratio, and triglycerides. Analysis of the separate effects of the Low-Sat diet without energy restriction and of weight loss in the sequential group showed that weight loss per se was responsible for about 50% of the total reduction in total cholesterol, and for about 60% and 70% of the fall in LDL cholesterol and triglycerides, respectively. Fat modification without weight loss reduced HDL cholesterol by 11.1% and the HDL/LDL ratio by 7.7%, while weight loss per se led to increases in HDL cholesterol of 12.5% and in the HDL/LDL ratio of 24.0%. We conclude that the effects of reduction in fat and saturated fat intake and weight loss are additive.(ABSTRACT TRUNCATED AT 250 WORDS)
Contribution of Human α-Defensin 1, 2, and 3 to the Anti-HIV-1 Activity of CD8 Antiviral Factor (2002)

It has been known since 1986 that CD8 T lymphocytes from certain HIV-1-infected individuals who are immunologically stable secrete a soluble factor, termed CAF, that suppresses HIV-1 replication. However, the identity of CAF remained elusive despite an extensive search. By means of a protein-chip technology, we identified a cluster of proteins that were secreted when CD8 T cells from long-term nonprogressors with HIV-1 infection were stimulated. These proteins were identified as alpha-defensin 1, 2, and 3 on the basis of specific antibody recognition and amino acid sequencing. CAF activity was eliminated or neutralized by an antibody specific for human alpha-defensins. Synthetic and purified preparations of alpha-defensins also inhibited the replication of HIV-1 isolates in vitro. Taken together, our results indicate that alpha-defensin 1, 2, and 3 collectively account for much of the anti-HIV-1 activity of CAF that is not attributable to beta-chemokines.
Discography with manometry and discographic CT: their value in patient selection for percutaneous lumbar nucleotomy. (1996)

In minimally invasive spinal surgery and percutaneous disc surgery the exact preoperative structural analysis of the disc herniation becomes a prerequisite in patient selection. Discography including discal manometry and discographic CT (in addition to CT and MRI) are used to review the anatomy of disc herniations prior to surgery. The analysis of the findings of discography in 360 lumbar discs examined from 1988 to 1994 are presented. In 68 discs operated with hemilaminectomy, later intraoperative findings were available for comparison with preoperative discographic findings. The diagnostic accuracy of determining the exact anatomical location of the herniation with discography alone was 75%. The diagnostic accuracy increased to 99.55% with the use of CT discography. The authors conclude that CT discography is an accurate and useful diagnostic aid.
Single crystal superconductor nanowires by electrodeposition (1999)

Superconducting Pb wires (diameter∼50 nm) have been prepared by pulse electrodeposition in nanoporous membranes. Single crystal or polycrystalline nanowires may be grown selectively and reproducibly depending on the pulse parameters. Unexpectedly, the growth of single crystal wires requires a greater departure from equilibrium conditions (greater overpotential) than the growth of polycrystalline ones. The importance of controlling the crystal texture is demonstrated by measurements of the superconducting transition temperature Tc which give significantly different results for polycrystalline and single crystal nanowires.
Josephson edge-triggered gates for sequential circuits (1991)

A Josephson sequential logic family with a very wide operating margin (+or-67%) and insensitivity to global parameter variations is proposed. Derived from the original idea of the edge-triggered latching comparator by C. Hamilton et al. (see IEEE Trans Magnetics, vol.MAG-21, p.197-9, 1985), this logic gate consists of a pair of conventional gates in series biased by a delay clock. In normal operation, switching occurs in one and only one of the gates, depending on which one has the smaller critical current. The authors have built and tested a few circuits to illustrate this logic gate design: a 32-b shift register designed by OR gates with +or-42% bias margin and +or-89% input margin, a 4-b pseudorandom sequence generator designed by exclusive-OR gates with +or-27% bias margin and +or-78% input margin, and cross section of a 6-b NOR gate decoder with +or-33% bias margin.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Aging and malignant hemopathies (2015)

improve the classification of the disease and will lead to therapeutic biomarkers. In fact, there is a clinical need to extend our current limited therapeutic portfolio by the detection of innovative therapeutic targets. 20 In the interest of our patients, we hope that these efforts will extend our therapeutic armamentarium in the near future and will offer truly personalized approaches.
Low dark-current, high-efficiency planar In<sub>0.53</sub>Ga<sub>0.47</sub>As/InP P-I-N photodiodes (1981)

We have fabricated high quantum efficiency, high speed, low dark-current In <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.53</inf> Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.47</inf> As/InP p-i-n planar photodiodes Which meet the performance requirements of long-wavelength optical communications systems. The diodes employ plasma deposited SiN <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> as a mask to Zn diffusion. The dark-current density at 10 V is J = 5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> with a corresponding capacitance of C = 5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> F/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Antibody Responses to DNA in Normal Immunity and Aberrant Immunity (1998)

Among antibodies directed to biological macromolecules, antibodies to DNA (anti-DNA) are unique in their association with the pathological state. These antibodies are the serologic hallmark of systemic lupus erythematosus (SLE) and serve as markers for diagnosis and prognosis. Furthermore, as indicated by the correlation of antibody levels with disease activity, anti-DNA play a major role in the pathogenesis of lupus nephritis. The close association of anti-DNA with SLE has implied that immune responses to DNA are an exclusive feature of autoimmune disease (5). Although assessment of anti-DNA remains clinically valuable, recent data suggest that the current conceptualization of anti-DNA needs revision. These data provide a new perspective on lupus serology and show clearly that production of anti-DNA occurs in hosts with normal immunity as well as those with aberrant immunity. The salient feature of the production of normal anti-DNA, however, is its specificity for bacterial DNA. Furthermore, as shown in studies with both mice and humans, antibody induction is just one facet of bacterial DNA’s far-reaching immunological properties. This review considers current information on antibody responses to DNA, focusing on their role in SLE as well as normal host defense.
Cyclophilin C-associated protein: A normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses<i>in vivo</i> (1999)

Mouse cyclophilin C-associated protein (CyCAP) is a member of the scavenger-receptor cysteine-rich domain superfamily and is 69% identical to the human Mac-2 binding protein. Here, we show that CyCAP is a widely expressed secreted glycoprotein that modulates the host response to endotoxin. Gene-targeted CyCAP-deficient mice are more sensitive to the lethal effects of endotoxin. In response to endotoxin, CyCAP-deficient mice overproduced interleukin 12 and interferon-gamma systemically and tumor necrosis factor alpha locally; these are proinflammatory molecules that also promote T helper 1 responses. Furthermore, macrophages stimulated in vitro with endotoxin in serum deficient in CyCAP secreted more tumor necrosis factor alpha, supporting the proposal that CyCAP specifically down-modulates endotoxin signaling.
Charge comparison protection of transmission lines-relaying concepts (1992)

The authors describe the relaying concepts of charge comparison. Charge comparison is a new transmission line protection system. It is a form of current differential relaying. Charge comparison largely resolves the traditional problems of current differential relaying of transmission lines, which are that protection is lost if a channel fails, a large channel capacity is required, and precise channel delay compensation is required. This technique is suitable for the protection of two- or three-terminal AC transmission lines, of all lengths and voltage levels, with or without series of shunt compensation, with three-hole or single-pole tripping.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Allogeneic hematopoietic cell transplantation after fludarabine and 2 Gy total body irradiation for relapsed and refractory mantle cell lymphoma (2004)

We carried out HLA-matched related (n = 16) and unrelated (n = 17) hematopoietic cell transplantation (HCT) in 33 patients with relapsed and refractory mantle cell lymphoma after nonmyeloablative conditioning with fludarabine and 2 Gy total body irradiation. Postgrafting immunosuppression consisted of cyclosporine and mycophenolate mofetil. Fourteen patients had failed high-dose autologous HCT. Of the 33 patients studied, 31 had stable engraftment, whereas 2 patients experienced nonfatal graft rejections. The incidences of acute grades II, III, and IV, and chronic graft-versus-host disease (GVHD) were 27%, 17%, 13%, and 64%, respectively. The overall response rate in the 20 patients with measurable disease at the time of HCT was 85% (n = 17; 75% complete remissions [CR] and 10% partial remissions [PR]), whereas 3 patients had progressive disease. Only one of the 17 patients who responded and none of the 13 who received transplants in CR had disease relapse with a median follow-up of 24.6 months. Relapse and nonrelapse mortalities were 9% and 24%, respectively, at 2 years. The Kaplan-Meier probabilities of overall and disease-free survivals at 2 years were 65% and 60%, respectively. Allogeneic HCT after nonmyeloablative conditioning is a promising salvage strategy for patients with relapsed and refractory mantle cell lymphoma. The high response and low relapse rates with this approach suggest that mantle cell lymphoma is susceptible to graft-versus-tumor responses.
Combined OFDM-CDMA configuration for multimedia wireless applications (1996)

This paper analyses the applicability of OFDM modulation when combined with CDMA for multimedia wireless systems operating in an indoor environment. We demonstrate the motivations and benefits deriving from this combination. Particular emphasis is given to channel equalisation techniques, designed to face different problems arising in the up-link and in the down-link. In particular, an equalisation technique based on channel inversion, combined with carrier interleaving and adaptive suppression of noisy carriers, is proposed in the down-link, while a pre-equalisation approach is used in the up-link. The analysis provides both BER performance and computational cost of the most important procedures that are to be implemented within multimedia terminals. The computational cost analysis is carried out using commercial DSP platforms.
Molecular Design and Characterization of Chromic Polyfluorene Derivatives (2000)

The thermochromic and solvatochromic properties of a series of fluorene-based conjugated polymers have been investigated. Both poly(2,7-(9,9-dioctylfluorene)) and poly(2,5-(thiophene)-alt-2,7-(9,9-dioctylfluorene)) have revealed interesting chromic properties which, on the basis of theoretical calculations, seem to be related to a relatively flexible backbone. On the other hand, the sterically hindered, nonplanar poly(2,5-(3,4-dimethylthiophene)-alt-2,7-(9,9-dioctylfluorene)) does not exhibit any significant solvatochromic and thermochromic properties which could be explained by an important energy barrier against planarity. Finally, investigations on poly(2,5-(3,4-ethylenedioxythiophene)-alt-2,7-(9,9-dioctylfluorene)) have revealed a highly conjugated conformational structure which is not significantly modified upon temperature or solvent changes.
Apolipoprotein E polymorphism and expression in type 2 diabetic patients with nephropathy: clinicopathological correlation (2009)

Our findings confirm the risk association of the ApoE polymorphism with diabetic nephropathy in clinical studies and is the first study demonstrating the correlations between ApoE genotypes, protein expression and structural changes in diabetic nephropathy.
Development of low-temperature properties on biodiesel fuel: a review (2015)

The use of biodiesel as a diesel fuel alternative is rapidly increasing. An important aspect of applying this alternative is the transportation and application in cold weather. In this article, different kinds of methods and technologies were briefly reviewed to improve the low-temperature properties of biodiesel. The compositions of fatty acids would be effectively changed by choosing available material with high content of unsaturated fatty acids or by reducing saturated fatty acids via winterization process. Branched alcohols can be used to change biodiesel structures that improve the low-temperature properties. As a technically feasible method, there is still a constant demand to search cost-effective raw materials for economic branched alcohols production. In order to enhance the impact of crystal morphology and decrease freezing point, the blending chemical additives and petroleum fuels would be a promising method that have been widely used. Besides, other treatments such as epoxidation, hydroisomerization, and ozonization were also discussed. However, each method applied for improving low-temperature properties of biodiesel should be effective and economical so that the biodiesel would continue to compete with fossil and other renewable fuels for market share. Copyright © 2015 John Wiley & Sons, Ltd.
Performance analysis of cellular networks (1991)

Dynamic channel allocation can reduce the probability of blocking in cellular telephone networks. However, more is needed to achieve optimal performance. The author aims at estimating the minimal blocking probability for some simple cellular networks. Some dynamic channel allocation strategies are analyzed, the optimal performance (obtained by dynamic allocation and flow control) of some very simple networks is computed, and simple bounds on optimal performance are presented. These results lead to a better understanding of cellular networks and can be used to evaluate new control algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Generative Adversarial Networks for Image and Video Synthesis: Algorithms and Applications (2020)

The generative adversarial network (GAN) framework has emerged as a powerful tool for various image and video synthesis tasks, allowing the synthesis of visual content in an unconditional or input-conditional manner. It has enabled the generation of high-resolution photorealistic images and videos, a task that was challenging or impossible with prior methods. It has also led to the creation of many new applications in content creation. In this paper, we provide an overview of GANs with a special focus on algorithms and applications for visual synthesis. We cover several important techniques to stabilize GAN training, which has a reputation for being notoriously difficult. We also discuss its applications to image translation, image processing, video synthesis, and neural rendering.