gebhart/patrepeval huggingface dataset:
Anti-progesterone antibody administration and the impairment of postpartum maternal care in mice (1995)

Passive transfer of a monoclonal antibody against progesterone produces a high incidence of maternal rejection in mice after recovery from antibody-induced infertility. To investigate the mechanisms involved in this reduction of maternal care, we have examined whether the effect is due to long-term exposure to antibody. Antibody was administered i.p. either on day 2 or day 17 of pregnancy. When a low dose (1.0 nmol) was given on day 2, pregnancy proceeded normally but 44.8% pups delivered at term were rejected compared with 12.7% in the control group. When a higher dose (4.5 nmol) of antibody was given on day 17, pregnancy continued normally to term and the rejection rate was 48.8% (control: 11.1%). When the same amount of antibody was injected after delivery (day 1 of lactation), no detrimental effect was found on subsequent maternal care to the young, the rejection rate being comparable between antibody-treated and control groups (5.3% vs 4.6%). To determine if the presence of antibody interfered with lactation or suckling, a bolus injection of 10 microCi [3H]H2O was given to mice treated at day 17 with antibody or saline. The levels of radioactivity present in both mothers and pups and the first 5-day pup growth curves showed identical patterns, indicating that milk availability and the suckling process were not affected. Crossfostering studies revealed that antibody-treated mothers rejected 25.5% of fostered pups compared with 8.5% found in the control females when antibody was administered on day 17 of pregnancy and the entire litters were crossfostered between the two groups immediately after delivery.(ABSTRACT TRUNCATED AT 250 WORDS)
Radiation from cylindrical leaky waves (1990)

Formulas are derived for the far-infrared radiation pattern of cylindrical leaky waves propagating on a planar surface. The formulas can be used to predict the radiation pattern of a general class of leaky-wave antennas, consisting of a finite-size source which excites a radially propagating leaky wave on some planar surface. Leaky-wave antennas consisting of antenna elements embedded in dielectric layers (microstrip elements) fall into this category. Using the equivalence principle, formulas are derived for both transverse electric (TE) and transverse magnetic (TM) leaky waves with arbitrary propagation constants. The formulas allow for radiation from cylindrical apertures of arbitrary size, so that the effect of truncating the supporting planar surface with an absorbing material can be determined. Particular attention is devoted to the case of a leaky wave for which the real and imaginary parts of the complex propagation constant are equal, since this type of wave has been shown to be responsible for broadside radiation in certain leaky-wave antennas comprised of dielectric layers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lipin Family Proteins - Key Regulators in Lipid Metabolism (2014)

This review introduces the structural characteristics, physiological functions, relationship to lipid metabolism, and patterns of expression of the lipin family proteins, highlighting their roles in lipid metabolic homeostasis.
An experimental system for automatic recognition of personal titles and personal names in newspaper texts (1967)

Natural language seems to contain various special-purpose sublanguages (e.g., personal titles, personal names) --each with its own structure which relative to the total structure of language is quite simple.
<i>Candida albicans</i> Hyr1p Confers Resistance to Neutrophil Killing and Is a Potential Vaccine Target (2010)

Candida albicans is the most common cause of invasive fungal infections in humans. It is unclear how C. albicans escapes from phagocytic attack and survives in the hostile blood environment during life-threatening systemic infections. Using a conditional overexpression or suppression genetic strategy, we discovered that HYR1 gene reduced phagocytic killing activity of C. albicans in vitro and increased tissue fungal burden in vivo. Concordant with its positive regulation by the transcription factor Bcr1p, autonomous expression of HYR1 complemented the hypersusceptibility to phagocyte-mediated killing of a bcr1 null mutant of C. albicans in vitro. As for C. albicans, heterologous expression of HYR1 in Candida glabrata rendered the organism more resistant to neutrophil killing activity. Vaccination with a recombinant Hyr1p significantly protected mice against hematogenously disseminated candidiasis (P = .001). Finally, anti-rHyr1p polyclonal antibodies enhanced mouse neutrophil killing activity by directly neutralizing rHyr1p effects in vitro. Thus, Hyr1 is an important virulence factor for C. albicans, mediating resistance to phagocyte killing. Hyr1p is a promising target for vaccine or other immunological or small molecule intervention to improve the outcomes of disseminated candidiasis.
The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population (2001)

The allele frequencies for a Pro12-->Ala substitution in peroxisome proliferator-activated receptor-gamma differ among ethnic groups, and its relationship with diabetes and associated diseases is controversial. The prevalence of this polymorphism and its effects on clinical characteristics have now been evaluated with a large number of Japanese individuals with type 2 diabetes (n = 2,201) and normal control subjects (n = 1,212) recruited by 10 institutions located in seven different cities in Japan. The allele frequency for the Ala12 variant was significantly lower in the type 2 diabetic group than in the control group (2.39 vs. 4.13%, P = 0.000054). However, compared with subjects without the Ala12 variant, the diabetic subjects with this variant exhibited a significantly higher serum concentration of total cholesterol (P = 0.001), manifested a reduced capacity for insulin secretion as evaluated by homeostasis model assessment (P = 0.007), and tended to possess a higher level of HbA1c. These data suggest that the Ala12 variant is associated with a reduced risk for the development of diabetes in the general population, but that it may be also a risk factor for insulin deficiency and disease severity in individuals with type 2 diabetes.
A new architecture for secure storage and sharing of health records in the cloud using federated identity attributes (2014)

Cloud computing is a technological service that has become a trend. This paradigm adds many benefits to storage of personal health records (PHR) and electronic health records (EHR), such as availability and on-demand provisioning. It also facilitates sharing of health records among doctors, family members, friends and clinicians in general. However, this technology increases the risk of leaking sensitive health data. Aiming at mitigating this problem, we present here a new architecture that takes advantage of identity federation for secure storage and sharing of PHR and EHR in the cloud environment.
Lipid apheresis in an animal model causes in vivo changes in lipoprotein electrophoretic patterns (1996)

Lipid apheresis, a new extracorporeal procedure based on plasma delipidation and showing promise as a possible treatment for atherosclerosis, was recently reported for the first time from this laboratory [Cham et al., J Clin Apheresis 10:61-69, 1995]. In the present study lipid apheresis was applied to hypercholesterolemic and normocholesterolemic roosters to examine its effect on plasma lipoprotein particles. This procedure resulted in conspicuous changes in electrophoretic patterns of plasma lipoproteins. The electrophoretic mobilities of all the lipoprotein fractions had changed considerably. Lipid stainable material was present in at least three bands in the alpha-globulin area. In particular, changes in the electrophoretic region of high-density lipoproteins were observed. Lipid apheresis markedly induced the anti-atherogenic pre- beta-high-density lipoproteins. The observed changes induced by lipid apheresis were more pronounced in the hyperlipidemic animals compared with the normocholesterolemic controls. A novel pre-alpha-lipoprotein band was observed soon after lipid apheresis. This lipoprotein band had a density larger than 1.21. At approximately 150 minutes after lipid apheresis, the electrophoretic pattern had almost returned to its original base pattern. Lipid apheresis results in plasma lipoprotein changes which may induce reverse cholesterol transport and shows promise as a possible treatment of atherosclerosis.
The in vitro NADPH-dependent inhibition by CCl4 of the ATP-dependent calcium uptake of hepatic microsomes from male rats. Studies on the mechanism of the inactivation of the hepatic microsomal calcium pump by the CCl3.radical. (1990)

The hepatotoxicity of CCl4 is mediated through its initial reduction by cytochrome P-450 to the CCl3.radical. This radical then damages important metabolic systems such as the ATP-dependent microsomal Ca2+ pump. Previous studies from our laboratory on isolated microsomes have shown that NADPH in the absence of toxic agents inhibits this pump. We have now found in in vitro incubations that CCl4 (0.5-2.5 mM) enhanced the NADPH-dependent inhibition of Ca2+ uptake from 28% without CCl4 to a maximum of 68%. These concentrations are in the range found in the livers and blood of lethally intoxicated animals (Dambrauskas, T., and Cornish, H. H. (1970) Toxicol. Appl. Pharmacol. 17, 83-97; Long, R.M., and Moore, L. (1988) Toxicol. Appl. Pharmacol. 92, 295-306) and are toxic to cultured hepatocytes (Long, R. M., and Moore, L. (1988) Toxicol. Appl. Pharmacol. 92, 295-306). The inhibition of Ca2+ uptake was due both to a decrease in the Ca2(+)-dependent ATPase and to an enhanced release of Ca2+ from the microsomes. The NADPH-dependent CCl4 inhibition was greater under N2 and was totally prevented by CO. GSH (1-10 mM) added during the incubation with CCl4 prevented the inhibition. This protection was also seen when the incubations were performed under nitrogen. When samples were preincubated with CCl4, the CCl4 metabolism was stopped, and then the Ca2+ uptake was determined; GSH reversed the CCl4 inhibition of Ca2+ uptake. This reversal showed saturation kinetics for GSH with two Km values of 0.315 and 93 microM when both the preincubation and the Ca2+ uptake were performed under air, and 0.512 and 31 microM when both were performed under nitrogen. Cysteine did not prevent the NADPH-dependent CCl4 inhibition of Ca2+ uptake. CCl4 increased lipid peroxidation in air, but no lipid peroxidation was seen under nitrogen. Lipid peroxidation was only modestly reversed by GSH. GSH did not remove 14C bound to samples preincubated with the 14CCl4. Although EDTA (100 microM) decreased the CCl4 inhibition, the metal-complexing agents deferoxamine (100 microM) and diethyldithiocarbamate (100 microM) had no effect on the inhibition of the pump. Similarly, the reactive oxygen scavengers catalase (65 micrograms/ml), superoxide dismutase (15 micrograms/ml), mannitol (10 mM), and dimethyl sulfoxide (50 mM) also had no effect. Our results suggest that the initial toxicity of CCl4 for the Ca2+ pump results from the metabolism of CCl4 to the CCl3. radical. This radical then directly oxidizes the Ca2+ pump, leading to decreased Ca2+ uptake.(ABSTRACT TRUNCATED AT 400 WORDS)
The Preparation and Properties of Certain Acetylenic Tertiary Carbinols (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation and Properties of Certain Acetylenic Tertiary CarbinolsA. F. Thompson Jr., John G. Burr Jr., and E. N. ShawCite this: J. Am. Chem. Soc. 1941, 63, 1, 186–188Publication Date (Print):January 1, 1941Publication History Published online1 May 2002Published inissue 1 January 1941https://pubs.acs.org/doi/10.1021/ja01846a043https://doi.org/10.1021/ja01846a043research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification of a novel and mutant RHCE*ce allele (2014)

Objective To analyze the RHCE genotyping in 200 RhD-negative donors from Guangzhou by using the novel Multiplex Ligation-dependent Probe Amplification( MLPA) RH genotyping assay kit. Methods Genomic DNAs were extracted from the peripheral blood samples of 200 RhD-negative donors,and the MLPA assay kit was used for the RHCE genotyping and quantitative analysis of the copy numbers of RHCE allele. Then,ten exons of RHCE gene were amplified and sequenced in the samples with abnormal copy numbers of RHCE allele in MLPA. Heterozygous mutations were further analyzed by clone sequencing. Results In the 200 RhD-negative donors,the copy numbers of RHCE allele in 6 samples decreased in MLPA genotyping assay. A novel heterozygous mutation( c. 308C T,p. 103Pro Leu) located in exon 2 of RHCE gene was identified,and then this novel mutation was verified by clone sequencing. Conclusion A novel and mutant RHCE*ce( 308C T) allele was identified for the first time in the Chinese population,and the frequency of this allele in RhD negative donors from Guangzhou was 6 /400.
The Reflection and Transmission of Infrared Materials: II, Bibliography (1963)

The papers in this bibliography give data on the infrared reflection and transmission of fifteen optical materials. Index of refraction papers are also included. The papers are listed according to material and are arranged alphabetically by the first author in each section.
Learning When to Use the Definite Article with English Proper Names (2007)

One of the most difficult aspects of English language learning is the use of articles. This paper studies the rules which explain whether an English proper noun can be preceded by the article the. In English proper nouns such as the United States, the Bible, the Arctic Circle or the Ohio River contain the in the beginning while proper nouns such as America, President Bush, Lake Tohata or Niagara Falls do not allow use of the article. For such a language phenomenon, grammar books usually only provide two lists: one contains the proper nouns accompanied by the, while the other contains the proper nouns that occur without the. Such a categorization without explanations creates a heavy load on the EFL learner's memory. This paper points out that for most proper nouns in English, the concept of the syntactic head of a noun phrase can be applied to explain the use or non-use of the definite article in such cases. With such a syntactic distinction, it can be found that only several semantic types of proper nouns reject the use of the definite article without explanations. With these syntactic and semantic distinctions, we can find that the use of the definite article the in an English proper noun can be logically explained without the student depending too much on mere memorization. Learning the use of articles with proper nouns needs not to be a random task.
Antimicrobial and Antioxidant Activity of Crude Extracts of Two Medicinal Plants Pistacia Integerrima and Debregeasia Salicifolia (2013)

The methanolic extracts of different parts of the two medicinal plants Pistacia integerrima Stewart Ex Brandis (Anacardiaceae) and Debregeasia salicifolia Rendle (Urticaceae) were studied for in vitro antimicrobial and antioxidant activity. The antimicrobial study was carried against various species of bacteria. Gram positive bacteria consisted of Staphylococcus aureus, Bacillus subtilis and Gram negative of Proteus mirabilis, Salmonella typhi, Escherichia coli and Citrobacter. The antioxidant study was performed through DPPH (1, 1-diphenyl-2-picrylhydrazyl) radical scavenging activity using ascorbic acid as standard. Roots and bark showed high zones of inhibition at low concentrations while the leaves showed activity at high dose concentrations of the crude extracts. Debregeasia salicifolia was effective against Bacillus subtilis with zone of inhibition 17.50 mm and at a dose of 150 µg. The highest zone of inhibition was shown by Pistacia integerrima leaves up to 28.00 mm against Citrobacter at the highest test dose of the extract, while the bark of Pistacia integerrima was also very effective showing a zone of inhibition of 21.80 mm against Staphylococcus aureus even at a very small dose of 150 µg. The crude extracts were compared against two standard drugs neomycin and doxycyclin. Pistacia integerrima bark and leaves were highly effective as free radical scavengers and the results were comparable to the standard ascorbic acid, while the leaves and roots of Debregeasia salicifolia also showed a very potent anti-oxidant activity but still less effective then Pistacia integerrima.
Crucial roles of the Arp2/3 complex during mammalian corticogenesis (2016)

The polarity and organization of radial glial cells (RGCs), which serve as both stem cells and scaffolds for neuronal migration, are crucial for cortical development. However, the cytoskeletal mechanisms that drive radial glial outgrowth and maintain RGC polarity remain poorly understood. Here, we show that the Arp2/3 complex - the unique actin nucleator that produces branched actin networks - plays essential roles in RGC polarity and morphogenesis. Disruption of the Arp2/3 complex in murine RGCs retards process outgrowth toward the basal surface and impairs apical polarity and adherens junctions. Whereas the former is correlated with an abnormal actin-based leading edge, the latter is consistent with blockage in membrane trafficking. These defects result in altered cell fate, disrupted cortical lamination and abnormal angiogenesis. In addition, we present evidence that the Arp2/3 complex is a cell-autonomous regulator of neuronal migration. Our data suggest that Arp2/3-mediated actin assembly might be particularly important for neuronal cell motility in a soft or poorly adhesive matrix environment.
Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity (2019)

Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics. Both palmitoylation by palmitoyl acyl transferases (PAT) and depalmitoylation by palmitoyl-protein thioesterases (PPT) is regulated in an activity-dependent, localized fashion. Recently, palmitoylation has received attention for its pivotal contribution to various forms of synaptic plasticity, the dynamic modulation of synaptic strength in response to neuronal activity. For instance, palmitoylation and depalmitoylation of the central postsynaptic scaffold protein postsynaptic density-95 (PSD-95) is important for synaptic plasticity. Here, we provide a comprehensive review of studies linking palmitoylation of postsynaptic proteins to synaptic plasticity.
Suaveolindole, a New Mass-Limited Antibacterial Indolosesquiterpene from <i>Greenwayodendron </i><i>s</i><i>uaveolens </i>Obtained via High-Throughput Natural Products Chemistry Methods (2005)

Utilizing high-throughput isolation, purification, and analysis methods applied to a natural products library, a new mass-limited antibacterial indolosesquiterpene, suaveolindole (1), was obtained from Greenwayodendron suaveolens. The miniaturization of the structure elucidation of 1 was performed primarily using the CapNMR probe. Compound 1 was found to possess significant in vitro antibacterial activity against the Gram-positive bacteria Bacillus subtilis (ATCC 43223), Staphylococcus aureus (ATTC 6538P), and methicillin-resistant Staphylococcus aureus (ATTC 33591), with MIC values of 4, 8, and 8 microg/mL, respectively.
Fault coverage estimation for early stage of VLSI design (2003)

This paper proposes a new fault coverage estimation model which can be used in the early stage of VLSI design. The fault coverage model is an exponentially decaying function with three parameters, which include the fault coverage upper bound, UB, the fault coverage lower bound, LB, and the rate of fault coverage change, /spl alpha/. The fault coverages using three different testing scenarios, which are no DFT, scan, iddq testing, are predicted using circuit design information, such as gate count, I/O count, and FF count. These parameters are often readily available at the early stage of VLSI design. Finally, the composite fault coverage is estimated by combining different fault coverages. Experimental result showed a 1.9% model estimation error with a given circuit information in the early design.
Regulation of Taurine Transport Systems by Protein Kinase CK2 in Mammalian Cells (2011)

Maintaining cell volume is critical for cellular function yet shift in cell volume is a prerequisite for mitosis and apoptosis. The ubiquitously and evolutionary conserved serine/threonine kinase CK2 promotes cell survival and suppresses apoptosis. The present review describes how mammalian cells regulate the cellular content of the major cellular organic osmolyte, taurine with emphasis on CK2 mediated regulation of active taurine uptake and volume-sensitive taurine release. Furthermore, we discuss how CK2-mediated regulation of taurine homeostasis is potentially involved in cellular functions such as proliferation and survival.
[Collagenolytic enzymes synthesized by microorganisms]. (1997)

The review uses data obtained by the authors and available in the literature to discuss microbial collagenolytic enzymes, widely employed in scientific research, biotechnology, and medicine. Collagenases differing in their structure and the specificity of their action on collagen fibrils were isolated from bacteria (including marine isolates), actinomycetes, and fungi. Collagenases produced by Clostridium histolyticum and Achromobacter iophagus are the best studied enzymes; both are metalloenzymes that contain Zn2+ in their active site and retain collagenolytic activity in the presence of Ca2+. Serine-type collagenolytic proteases were also found in microorganisms. These enzymes differ from "true" collagenases by the structure of their active site. Both serine proteases and metalloproteases with high collagenolytic activities were isolated from the culture liquids of Streptomyces and Actinomyces strains. The biosynthesis of collagenases is induced by the addition of various collagen-containing substrates to the cultivation medium.