gebhart/patrepeval huggingface dataset:
Yield of free ions in irradiated liquids; determination by a clearing field (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTYield of free ions in irradiated liquids; determination by a clearing fieldWerner F. Schmidt and Augustine O. AllenCite this: J. Phys. Chem. 1968, 72, 11, 3730–3736Publication Date (Print):October 1, 1968Publication History Published online1 May 2002Published inissue 1 October 1968https://pubs.acs.org/doi/10.1021/j100857a005https://doi.org/10.1021/j100857a005research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations142LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Resveratrol and quercetin cooperate to induce senescence‐like growth arrest in C6 rat glioma cells (2009)

Glioma is the most frequent and malignant primary human brain tumor with dismal prognosis despite multimodal therapy. Resveratrol and quercetin, two structurally related and naturally occurring polyphenols, are proposed to have anticancer effects. We report here that resveratrol and quercetin decreased the cell number in four glioma cell lines but not in rat astrocytes. Low doses of resveratrol (10 microM) or quercetin (25 microM) separately had no effect on apoptosis induction, but had a strong effect on caspase 3/7 activation when administered together. Western blot analyses showed that resveratrol (10 microM) and quercetin (25 microM) caused a reduction in phosphorylation of Akt, but this reduction was not sufficient by itself to mediate the effects of these polyphenols. Most important, resveratrol and quercetin chronically administered presented a strong synergism in inducing senescence-like growth arrest. These results suggest that the combination of polyphenols can potentialize their antitumoral activity, thereby reducing the therapeutic concentration needed for glioma treatment.
Rapid screening for citrus canker resistance employing pathogen-associated molecular pattern-triggered immunity responses (2015)

Citrus canker, caused by the bacterial pathogen Xanthomonas citri ssp. citri (Xcc), has been attributed to millions of dollars in loss or damage to commercial citrus crops in subtropical production areas of the world. Since identification of resistant plants is one of the most effective methods of disease management, the ability to screen for resistant seedlings plays a key role in the production of a long-term solution to canker. Here, an inverse correlation between reactive oxygen species (ROS) production by the plant and the ability of Xcc to grow and form lesions on infected plants is reported. Based on this information, a novel screening method that can rapidly identify citrus seedlings that are less susceptible to early infection by Xcc was devised by measuring ROS accumulation triggered by a 22-amino acid sequence of the conserved N-terminal part of flagellin (flg22) from X. citri ssp. citri (Xcc-flg22). In addition to limiting disease symptoms, ROS production was also correlated with the expression of basal defense-related genes such as the pattern recognition receptors LRR8 and FLS2, the leucine-rich repeat receptor-like protein RLP12, and the defense-related gene PR1, indicating an important role for pathogen-associated molecular pattern-triggered immunity (PTI) in determining resistance to citrus canker. Moreover, the differential expression patterns observed amongst the citrus seedlings demonstrated the existence of genetic variations in the PTI response among citrus species/varieties.
Investigation of a Novel 24-Slot/14-Pole Six-Phase Fault-Tolerant Modular Permanent-Magnet In-Wheel Motor for Electric Vehicles (2013)

In this paper, a six-phase fault-tolerant modular permanent magnet synchronous machine (PMSM) with a novel 24-slot/14-pole combination is proposed as a high-performance actuator for wheel-driving electric vehicle (EV) applications. Feasible slot/pole combinations of the fractional-slot concentrated winding six-phase PMSM are elicited and analyzed for scheme selection. The novel 24-slot/14-pole combination is derived from the analysis and suppression of the magnetomotive force (MMF) harmonics. By making use of alternate-teeth-wound concentrated winding configuration, two adjacent coils per phase and unequal teeth widths, the phase windings of the proposed machine is magnetically, thermally isolated, which offers potentials of modular design and fault tolerant capability. Taking advantage of the leakage component of winding inductance, 1.0 per unit short-circuit current is achieved endowing the machine with short-circuit proof capability. Optimal design of essential parameters aiming at low eddy current losses, high winding factor and short-circuit-proof ability are presented to pave the way for a high-quality system implementation.
Combining transcription-based and acoustic-based speaker identifications for broadcast news (2012)

In this paper, we consider the issue of speaker identification within audio records of broadcast news. The speaker identity information is extracted from both transcript-based and acoustic-based speaker identification systems. This information is combined in the belief functions framework, which makes coherent the knowledge representation of the problem. The Kuhn-Munkres algorithm is used to optimize the assignment problem of speaker identities and speaker clusters. Experiments carried out on French broadcast news from the French evaluation campaign ESTER show the efficiency of the proposed combination method.
Ustekinumab Safety in Psoriasis, Psoriatic Arthritis, and Crohn’s Disease: An Integrated Analysis of Phase II/III Clinical Development Programs (2019)

ClinicalTrials.gov identifier: NCT00320216, NCT00267969, NCT00307437, NCT00454584, NCT00267956, NCT01009086, NCT01077362, NCT00265122, NCT00771667, NCT01369329, NCT01369342, and NCT01369355.
Cytomegalovirus-related sequence in an atypical cytopathic virus repeatedly isolated from a patient with chronic fatigue syndrome. (1994)

An atypical virus, cytopathic for human and animal fibroblasts, was repeatedly cultured from a patient with chronic fatigue syndrome. Viral particles, suggestive of cytomegalovirus (CMV) were seen by electron microscopy. Infected cells did not, however, stain with antisera specific for CMV, herpes, simplex virus, or human herpes-virus-6. Polymerase chain reaction (PCR) assays for these viruses were also negative. Two distinct products of approximately 1.5 kilobase pairs were amplified from virally infected cells using the human T lymphotropic virus-II tax gene reactive primer, SK44, in low stringency PCR. Sequencing of one of the amplified products showed a region of highly significant partial homology with the UL34 gene of CMV. The sequence of the other PCR product did not correspond with CMV or any other virus. DNA was extracted from the material pelleted by ultracentrifugation of filtered culture supernatants. It migrated in agarose gels as a single band of approximately 20 kpb. The banded DNA was digested with EcoRI and cloned. A 2.2 kbp plasmid containing the CMV-related sequence identified within the PCR product was recovered. Sequencing of this plasmid extended the region of partial sequence homology with CMV to include a portion of the UL35 gene of CMV. Initial sequencing of additional plasmids has confirmed the partial relatedness to CMV. The data indicate a novel type of CMV-related "stealth" virus that is able to establish a clinically persistent human infection.
Three-dimensional model of the human platelet integrin α <sub>IIb</sub> β <sub>3</sub> based on electron cryomicroscopy and x-ray crystallography (2002)

Integrins are a large family of heterodimeric transmembrane signaling proteins that affect diverse biological processes such as development, angiogenesis, wound healing, neoplastic transformation, and thrombosis. We report here the three-dimensional structure at 20-A resolution of the unliganded, low-affinity state of the human platelet integrin alpha(IIb)beta(3) derived by electron cryomicroscopy and single particle image reconstruction. The large ectodomain and small cytoplasmic domains are connected by a rod of density that we interpret as two parallel transmembrane alpha-helices. The docking of the x-ray structure of the alpha(V)beta(3) ectodomain into the electron cryomicroscopy map of alpha(IIb)beta(3) requires hinge movements at linker regions between domains in the crystal structure. Comparison of the putative high- and low-affinity conformations reveals dramatic conformational changes associated with integrin activation.
Designing an automated blood fractionation system (2008)

An automated, high throughput blood fractionation system offers a solution to the problem of processing human blood samples collected in vacutainers in a consistent manner and provides a means of ensuring data and sample integrity.
Silk reeling and testing manual (1999)

The continuous improvement and effective dissemination of the technology for silk reeling and testing are vital in meeting the ever increasing demand for quality raw silk throughout the world. This bulletin covers a wide range of techniques in the silk reeling industry. Details are given in each chapter on the handling of fresh cocoons, drying and storage of cocoons, cocoon boiling and reeling, raw silk-reeling and finishing, water quantity and quality, utilization of by-products and maintenance of the machinery used. An appendix illustrates the silkworm processes from larva to final production of silk.
Synthesis of (-)-.DELTA.9(11)-trans-tetrahydrocannabinol (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (-)-.DELTA.9(11)-trans-tetrahydrocannabinolColin G. Pitt, Julia W. Wildes, Ned H. Martin, and Monroe E. WallCite this: J. Org. Chem. 1971, 36, 5, 721–723Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March 1971https://pubs.acs.org/doi/10.1021/jo00804a024https://doi.org/10.1021/jo00804a024research-articleACS PublicationsRequest reuse permissionsArticle Views679Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Um plano para inventar o marketing de que necessitamos «hoje» (2008)

"O mundo em que o marketing actua mudou no essencial. Será que a investigação e a prática desta disciplina acompanharam esta evolução? A resposta é negativa. No coração da actual confusão está o desencontro entre o rigor académico e a relevância na gestão. Temos de repensar e transformar o campo do marketing de modo a alcançar um equilíbrio entre o rigor e a relevância. O artigo detalha sete estratégias que permitirão alcançar esse objectivo. O artigo prossegue explicando como colocá-las em prática - numa colaboração entre os práticos no terreno e os investigadores académicos."
Self-expandable prostheses in the tracheobronchial tree. (1993)

Under endoscopic and radiologic control, two types of self-expandable metal prostheses were implanted in tracheobronchial lesions to help reestablish airway caliber. Thirty-nine metal stent prostheses (6-20 mm in diameter) and 35 Gianturco stents (30 mm in diameter) were used in 55 adult patients with 62 lesions of the trachea (n = 33) or bronchi (n = 29). All lesions except one were endoscopically confirmed to be noninflammatory. Immediately after implantation, radiologic and endoscopic studies verified reestablishment of a satisfactory airway diameter in all patients. At a mean follow-up of 10.35 (range, 3-27) months, improvement in the respiratory status of 49 of the 55 patients (89%) was maintained and tolerance of the device was excellent. For the Wallstent endoprosthesis, the six complications observed at endoscopy were successfully treated. The Gianturco stent, however, led to a high rate of complications: 30% of cases had migration and/or rupture of the metallic mesh, potentially leading to obstruction or wall perforation; one case of respiratory distress was fatal. This procedure offers rapid epithelialization and incorporation of the device into the tracheobronchial wall.
Miller, Walter B. (2014)

Walter Miller was criminologist most known for his contributions to gang research and his work on lower‐class culture. Basically Miller believed that lower‐class culture has specific “focal concerns” and that the more closely one adhered to these, the more likely one was to be delinquent or criminal. Specifically, lower‐class boys were intensely socialized to these focal concerns in gang contexts and were likely to be involved in delinquency. Miller's ideas had a florescence in the late 1950s but became less current by the mid‐1970s.
Protein glycosylation analysis by HILIC‐LC‐MS of Proteinase K‐generated <i>N</i>‐ and <i>O</i>‐glycopeptides (2010)

Analysis of protein glycosylation is essential in order to correlate certain disease types with oligosaccharide structures on proteins. Here, a method for the MS characterization of site-specific protein glycosylation is presented. Using asialofetuin and fetuin as model substances, a protocol for glycopeptide dissection was developed based on unspecific proteolysis by Proteinase K. The resulting glycopeptides were then resolved by nanoscale hydrophilic interaction liquid chromatography-electrospray multistage MS. The early elution range of O-glycopeptides was clearly separated from the late elution range of N-glycopeptides. Glycopeptides were analyzed by ion trap-MS/MS, which revealed fragmentations of glycosidic linkages and some peptide backbone cleavages; MS(3) spectra predominantly exhibited cleavages of the peptide backbone and provided essential information on the peptide sequence. The previously reported N- and O-glycan attachment sites of fetuin could be confirmed; moreover using our method, the occupation of a new, additional O-glycosylation site serine 296 was found. In conclusion, this approach appears to be a valuable technique for in-depth analysis of the site-specific N-glycosylation and O-glycosylation of individual glycoproteins.
APOBEC3B and APOBEC3C Are Potent Inhibitors of Simian Immunodeficiency Virus Replication (2004)

In the human genome the apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC)3 gene has expanded into a tandem array of genes termed APOBEC3A-G. Two members of this family, APOBEC3G and APOBEC3F, have been found to have potent activity against virion infectivity factor deficient (Deltavif) human immunodeficiency virus 1 (HIV-1). These enzymes become encapsidated in Deltavif HIV-1 virions and in the next round of infection deaminate the newly synthesized reverse transcripts. The lentiviral Vif protein prevents the deamination by inducing the degradation of APOBEC3G and APOBEC3F. We report here that two additional APOBEC3 family members, APOBEC3B and APOBEC3C, have potent antiviral activity against simian immuno-deficiency virus (SIV), but not HIV-1. Both enzymes were encapsidated in HIV-1 and SIV virions and were active against Deltavif SIV(mac) and SIV(agm). SIV Vif neutralized the antiviral activity of APOBEC3C, but not that of APOBEC3B. APOBEC3B induced abundant G --> A mutations in both wild-type and Deltavif SIV reverse transcripts. APOBEC3C induced substantially fewer mutations. APOBEC3F was found to be active against SIV and sensitive to SIV(mac) Vif. These findings raise the possibility that the different APOBEC3 family members function to neutralize specific lentiviruses.
Meningococcal conjugate vaccines (2004)

Neisseria meningitidis is a leading cause of bacterial meningitis and sepsis in the US, Europe and in many other parts of the world, including parts of sub-Saharan Africa (known as the African ‘meningitis belt’). There are > 500,000 cases of meningococcal disease annually with an estimated death toll of 135,000 worldwide. Approximately 10 – 15 % of survivors experience significant morbidity in the form of neurological sequelae, including hearing loss, speech disorders, loss of limbs, mental retardation and paralysis. Disease is usually caused by N. meningitidis serogroups A, B, C, Y or W-135. Prevention of meningococcal disease includes isolation, chemoprophylaxis and vaccination with available polysaccharide vaccines. However, the polysaccharide meningococcal vaccines (i.e., A and C; A, C and W-135; or A, C, Y and W-135) initially developed in the 1970s are generally poorly immunogenic in children or require repeated doses and do not produce long-lasting immunity. Conjugate vaccine technology has been very successfully used in childhood vaccines for the prevention of other bacterial meningitis pathogens, including vaccines against Haemophilus influenzae serotype b (Hib) and more recently, the seven- and nine-valent conjugate pneumococcal vaccines. Newly released meningococcal conjugate vaccines against N. meningitidis serogroup C have been highly efficacious in young children and adolescents, with minimal side effects. Conjugate vaccines targeting other important meningococcal serogroups (e.g., N. meningitidis serogroup A, responsible for the large pandemic outbreaks and the majority of disease in sub-Saharan Africa and serogroups Y and W-135) are under development and together with the serogroup C conjugates, have the potential to significantly impact worldwide sporadic and epidemic meningococcal disease. The search for an effective serogroup B meningococcal vaccine remains elusive. This manuscript reviews the conjugate meningococcal vaccines and their potential for meningococcal disease prevention.
Mapless Navigation among Dynamics with Social-safety-awareness: a reinforcement learning approach from 2D laser scans (2020)

We consider the problem of mapless collision-avoidance navigation where humans are present using 2D laser scans. Our proposed method uses ego-safety to measure collision from the robot's perspective and social-safety to measure the impact of robot's actions on surrounding pedestrians. Specifically, the social-safety part predicts the intrusion impact of the robot's action into the interaction area with surrounding humans. We train the policy using reinforcement learning on a simple simulator and directly evaluate the learned policy in Gazebo and real robot tests. Experiments show the learned policy smoothly transferred to different scenarios without any fine tuning. We observe that our method demonstrates time-efficient path planning behavior with high success rate in the mapless navigation task. Furthermore, we test our method in a navigation task among dynamic crowds, considering both low and high volume traffic. Our learned policy demonstrates cooperative behavior that actively drives our robot into traffic flows while showing respect to nearby pedestrians. Evaluation videos are at https://sites.google.com/view/ssw-batman.
Imaging of Vascular Wall Fine Structure in the Human Retina Using Adaptive Optics Scanning Laser Ophthalmoscopy (2013)

Our results show that retinal vascular mural cells and wall structure can be readily resolved in healthy subjects using AOSLO with multiply scattered light imaging for retinal vessels with a lumen diameter greater than or equal to 10 μm. Our noninvasive imaging approach allows direct assessment of the cellular structure of the vascular wall in vivo with potential applications in retinal vascular diseases such as diabetes and hypertension.
Centralized ac/dc power conversion for electronic loads in a low-voltage dc power system (2006)

In this paper, an interface to be used as a centralized ac/dc converter for electronic loads is presented. The proposed interface is tested both in a simulation software and in a lab setup. The performance of the interface is studied during load transients (connection and disconnection), and during a grid transient, i.e. an unbalanced voltage dip. The result shows that the proposed interface does not affect the utility power quality in terms of low-frequency harmonics and has voltage-dip ride-through capability.
A method to judge the existence of implicit function (2000)

This paper illustrates a method to judge the existence of implicit function X=Q(y) when dual equation F(x,y)=0 , F y(x o,y o)≠0 but F x(x o,y o)=0 are given.
Development and Testing of a Pseudo-Three-Dimensional Model of Hydraulic Fracture Geometry (1986)

Summary A pseudo-three-dimensional (P3DH) model has been developed to describe realistically the evolution of geometry of a 3D hydraulic fracture produced by fluid injection into a reservoir. The present model bypasses the task of a fully 3D crack geometry calculation, which is at present prohibitively complex in the context of a complete practical fracturing simulator. The P3DH model presented formulates the problem in terms of equations for lateral fluid flow and crack opening for the main body of the fracture, coupled with a very efficient scheme for describing vertical fracture growth at each cross section. The equations for lateral flow are solved by finite differences, and the vertical propagation problem is solved by numerical implementation of a singular integral equation on a suitable set of Chebyshev points. The testing of P3DH components shows both an excellent agreement of the lateral propagation model with various analytical solutions (Ref. 1) and a strong sensitivity of vertical propagation to confining stress and stiffness contrast of adjacent strata and to fluid rheology. The sample simulations show that the model produces realistic fracture growth under a wide range of conditions, is extremely sensitive to the dominant containment parameters, and therefore can be used to study the effect of relevant design parameters on fracture shapes and pressures in stimulation treatments. The P3DH model is highly efficient and suitable for incorporation in a general 3D fracturing simulator. The computational effort for calculation of fracture geometry with P3DH is generally comparable to that required for the simulation of the fluid flow in the surrounding reservoir.
Analyse multivariée et structure régionale : transformations socio-économiques récentes dans le Massif Central de l'Est (1978)

Cet article se propose de mettre à jour, pour trois départements orientaux du Massif Central (l'Ardèche, la Lozère, la Haute-Loire) les différences qui se manifestent actuellement dans l'économie et la société, en opérant, pour chaque département, un regroupement simple et clair des cantons. Il illustre l'application, dans un contexte français, d'une méthode très utilisée récemment par les géographes britanniques et américains : l'analyse en composantes principales.