gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Synthesis and Pharmacological Evaluation of Some Novel 13‐(N,N‐ Dialkylamino‐alkyl)benzo(g)(2)benzopyrano(4,3‐b)indol‐5(13H)ones. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Burn injury causes mitochondrial dysfunction in skeletal muscle (2005)

Severe burn trauma is generally followed by a catabolic response that leads to muscle wasting and weakness affecting skeletal musculature. Here, we perform whole-genome expression and in vivo NMR spectroscopy studies to define respectively the full set of burn-induced changes in skeletal muscle gene expression and the role of mitochondria in the altered energy expenditure exhibited by burn patients. Our results show 1,136 genes differentially expressed in a mouse hind limb burn model and identify expression pattern changes of genes involved in muscle development, protein degradation and biosynthesis, inflammation, and mitochondrial energy and metabolism. To assess further the role of mitochondria in burn injury, we performed in vivo (31)P NMR spectroscopy on hind limb skeletal muscle, to noninvasively measure high-energy phosphates and the effect of magnetization transfer on inorganic phosphate (P(i)) and phosphocreatine (PCr) resonances during saturation of gammaATP resonance, mediated by the ATP synthesis reactions. Although local burn injury does not alter high-energy phosphates or pH, apart from PCr reduction, it does significantly reduce the rate of ATP synthesis, to further implicate a role for mitochondria in burn trauma. These results, in conjunction with our genomic results showing down-regulation of mitochondrial oxidative phosphorylation and related functions, strongly suggest alterations in mitochondrial-directed energy expenditure reactions, advancing our understanding of skeletal muscle dysfunction suffered by burn injury patients.
Transim: Transfer Image Local Statistics Across EOTFS for HDR Image Applications (2018)

Despite the popularity of high dynamic range (HDR) technology in recent years, various algorithms for image and video applications are still designed and optimized for traditional standard dynamic range (SDR) data. Directly applying SDR-optimized algorithms to HDR images and video will result in significant artifacts or coding deficiency. In this work, we present a novel preprocessing method, dubbed TransIm, which transfers local statistics for the images from the desired domain (e.g. SDR) to the current domain (e.g., HDR), while maintaining its current visual presence. It is achieved by controlling the less perceivable “noise” that is orthogonal to the sparsifiable image content, using a unitary sparsifying transform. Numerical results show that the proposed TransIm can effectively transfer local patch variance from Gamma domain to Perceptual Quantizer (PQ) domain for HDR videos. We also demonstrate that the TransIm outputs are more robust to distortions and artifacts in seam carving applications.
Development of Novel Bisphosphonate Prodrugs of Doxorubicin for Targeting Bone Metastases That Are Cleaved pH Dependently or by Cathepsin B: Synthesis, Cleavage Properties, and Binding Properties to Hydroxyapatite As Well As Bone Matrix (2012)

Bone metastases are a frequent cause of morbidity in cancer patients. The present palliative therapeutic options are chemotherapy, hormone therapy, and the administration of bisphosphonates. The affinity between bisphosphonates and the apatite structure of bone metastases is strong. Thus, we designed two low-molecular-weight and water-soluble prodrugs which incorporate a bisphosphonate group as a bone targeting ligand, doxorubicin as the anticancer agent, and either an acid-sensitive bond (1) or a cathepsin B cleavable bond (3) for ensuring an effective release of doxorubicin at the site of action. Cleavage studies of both prodrugs showed a fast release of doxorubicin but sufficient stability over several hours in human plasma. Effective binding of prodrug 1 and 3 was demonstrated with hydroxyapatite and with native bone. In orientating toxicity studies in nude mice, the MTD of 1 was 3-fold higher compared to conventional doxorubicin, whereas 3 showed essentially the same MTD as doxorubicin.
<i>m</i>‐Iodobenzylguanidine increases the mitochondrial Ca<sup>2+</sup> pool in isolated hepatocytes (1992)

The incubation of isolated hepatocytes with the inhibitor of protein mono ADP-ribosylation, m-iodobenzylguanidine (MIBG), resulted in an increase in the size of the mitochondrial Ca2+ pool, without alteration of the non-mitochondrial Ca2+ store(s). This increase was abolished when the cytosolic free Ca2+ concentration ([Ca2+]i) was buffered by prior loading of the cells with fluo 3. Elevating [Ca2+]i by releasing the endoplasmic reticular Ca2+ store with 2,5-di-(tert-butyl)-1,4-hydroquinone resulted in a synergistic increase in the magnitude of the mitochondrial Ca2+ pool. A role for protein ADP-ribosylation in the intracellular regulation of mitochondrial Ca2+ homeostasis is suggested.
Multi-phase-shifted helical long period fiber grating based temperature-insensitive optical twist sensor (2014)

A compact temperature-insensitive optical fiber twist sensor based on multi-phase-shifted helical long period fiber grating has been proposed and experimentally demonstrated in this paper. A multi-phase-shifted helical long period fiber grating is fabricated with a multi-period rotation technology. A π/2 and a 3π/2 phase shift is introduced in the helical long period fiber grating by changing the period. The helical pitch can be effectively changed with a different twist rate, which is measured by calculating the wavelength difference between two phase shift peaks. Although the wavelength of the phase shift peak also shifts with a change of the temperature, the wavelength difference between two phase shift peaks is constant due to two fixed phase shifts in the helical long period fiber grating, which is extremely insensitive to temperature change for the multi-phase-shifted helical long period fiber grating. The experimental results show that a sensitivity of up to 1.959 nm/(rad/m) is achieved.
Research on Well Trajectory Deduction Method Based on Pythagorean-Hodograph Quintic Space Curves (2019)

Abstract Considering the influence of key parameters such as bore angle, azimuth and sounding of wellbore, based on the spatial five-time PH curve with continuous unit tangent and directional curvature, no need for iteration, using Bessel polynomial interpolation method, optimization the spatial model and the curve description can accurately deduct the spatial parameters of the fifth point according to the determined four points of the space, and then establish the wellbore trajectory analytical equation to generate the well trajectory curve. Taking a directional well as an example, the wellbore trajectories of the wells from 403.9 meters to 976 meters were fitted by PH, cubic spline and linear interpolation method respectively, and compared with the real measuring points. The results show that the wells fitted by PH method, the differences of the bevel angle and the measured point, the azimuth angle and the measured point are 0.910° and 5.7°. The differences of the cubic spline and the measured point, the straight line method and the measured point are 4.240°, 5.86° and 6.54°, 9.09°. For the PH method, the trajectory inclination and azimuth differences are the smallest, which are 3.51% and 3.17%.
HIV Coinfection in Multidrug- and Extensively Drug-Resistant Tuberculosis Results in High Early Mortality (2009)

Mortality from MDR and XDR TB in this high HIV-prevalence region is extraordinarily high, particularly within the first 30 days. Efforts to reduce mortality must focus on earlier diagnosis and early initiation of second-line TB and antiretroviral therapy.
Three dimensional Terrain modeling and display for environmental assessment (1989)

A technique for compositing computer generated images of buildings and background images created from aerial photographs is described. The aerial photo data are mapped onto a terrain model based on cartographic data. The technique can be used to pre-evaluate visual impact of large scale construction by means of not only still images but also animations.The technique can be briefly described as follows: 1) an accurate, three-dimensional terrain model is created based on cartographic data. 2) a hierarchy of aerial photo data at various resolutions is mapped onto the terrain model as a texture. 3) the height of trees is taken into account in regions near the viewpoint. 4) allowing intersections of terrain models with constructions facilitates geometric adjustments and shadowing.
Performance of FPGA implementation of bit-split architecture for intrusion detection systems (2006)

The use of reconfigurable hardware for network security applications has recently made great strides as field-programmable gate array (FPGA) devices have provided larger and faster resources. The performance of an intrusion detection system is dependent on two metrics: throughput and the total number of patterns that can fit on a device. In this paper, we consider the FPGA implementation details of the bit-split string-matching architecture. The bit-split algorithm allows large hardware state machines to be converted into a form with much higher memory efficiency. We extend the architecture to satisfy the requirements of the IDS state-of-the-art. We show that the architecture can be effectively optimized for FPGA implementation. We have optimized the pattern memory system parameters and developed new interface hardware for communicating with an external controller. The overall performance (bandwidth * number of patterns) is competitive with other memory-based string matching architectures implemented in FPGA.
The NG domain of the prokaryotic signal recognition particle receptor, FtsY, is fully functional when fused to an unrelated integral membrane polypeptide (1997)

Recent studies have revealed that Escherichia coli possesses an essential targeting system for integral membrane proteins, similar to the mammalian signal recognition particle (SRP) machinery. One essential protein in this system is FtsY, a homologue of the alpha-subunit of the mammalian SRP-receptor (SR-alpha). However, E. coli does not possess a close homologue of the integral membrane protein SR-beta, which anchors SR-alpha to the membrane. Moreover, although FtsY can be found as a peripheral membrane protein, the majority is found soluble in the cytoplasm. In this study, we obtained genetic and biochemical evidence that FtsY must be targeted to the membrane for proper function. We demonstrate that the essential membrane targeting activity of FtsY is mediated by a 198-residue-long acidic N-terminal domain. This domain can be functionally replaced by unrelated integral membrane polypeptides, thus avoiding the need for specific FtsY membrane targeting factors. Therefore, the N terminus of FtsY constitutes an independent domain, which is required only for the targeting of the C-terminal NG domain of FtsY to the membrane.
Despite Increased CD4+Foxp3+ Cells within the Infection Site, BALB/c IL-4 Receptor-Deficient Mice Reveal CD4+Foxp3-Negative T Cells as a Source of IL-10 in <i>Leishmania major</i> Susceptibility (2007)

BALB/c IL-4Ralpha(-/-) mice, despite the absence of IL-4/IL-13 signaling and potent Th2 responses, remain highly susceptible to Leishmania major substain LV39 due exclusively to residual levels of IL-10. To address the contribution of CD4(+)CD25(+) T regulatory (Treg) cells to IL-10-mediated susceptibility, we depleted CD4(+)CD25(+) cells in vivo and reconstituted IL-4Ralpha x RAG2 recipients with purified CD4(+)CD25(-) T cells. Although anti-CD25 mAb treatment significantly decreased parasite numbers in IL-4Ralpha(-/-) mice, treatment with anti-IL-10R mAb virtually eliminated L. major parasites in both footpad and dermal infection sites. In addition, IL-4Ralpha x RAG2 mice reconstituted with CD4(+) cells depleted of CD25(+) Treg cells remained highly susceptible to infection. Analysis of L. major-infected BALB/c and IL-4Ralpha(-/-) inflammatory sites revealed that the majority of IL-10 was secreted by the CD4(+)Foxp3(-) population, with a fraction of IL-10 coming from CD4(+)Foxp3(+) Treg cells. All T cell IFN-gamma production was also derived from the CD4(+)Foxp3(-) population. Nevertheless, the IL-4Ralpha(-/-)-infected ear dermis, but not draining lymph nodes, consistently displayed 1.5- to 2-fold greater percentages of CD4(+)CD25(+) and CD4(+)Foxp3(+) Treg cells compared with the BALB/c-infected dermis. Thus, CD4(+)Foxp3(-) T cells are a major source of IL-10 that disrupts IFN-gamma activity in L. major-susceptible BALB/c mice. However, the increase in CD4(+)Foxp3(+) T cells within the IL-4Ralpha(-/-) dermis implies a possible IL-10-independent role for Treg cells within the infection site, and may indicate a novel immune escape mechanism used by L. major parasites in the absence of IL-4/IL-13 signaling.
Monolithically integrable active microwave inductor (1988)

A new approach to implementation of a GaAs monolithic microwave gyrator, or active inductor, is presented. The approach requires no resistors and only very small capacitors. The circuit is very compact, and facilitates small-area microwave inductors with values much larger than can be achieved by spiral inductors. A circuit built using this technique has an inductance of 5.8 nH over the frequency range of 45 MHz to 1 GHz. Methods to extend the operating frequency of the gyrator and improve the Q value of the active inductor are discussed.
Non-head-to-tail monoterpenes. Synthesis of (S)-lyratol and (S)-lyratyl acetate from (1R,3R)-chrysanthemic acid (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNon-head-to-tail monoterpenes. Synthesis of (S)-lyratol and (S)-lyratyl acetate from (1R,3R)-chrysanthemic acidRoger G. Gaughan and C. Dale PoulterCite this: J. Org. Chem. 1979, 44, 14, 2441–2444Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/jo01328a023https://doi.org/10.1021/jo01328a023research-articleACS PublicationsRequest reuse permissionsArticle Views615Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enhanced surface transfer doping of diamond by V2O5 with improved thermal stability (2016)

Surface transfer doping of hydrogen-terminated diamond has been achieved utilising V2O5 as a surface electron accepting material. Contact between the oxide and diamond surface promotes the transfer of electrons from the diamond into the V2O5 as revealed by the synchrotron-based high resolution photoemission spectroscopy. Electrical characterization by Hall measurement performed before and after V2O5 deposition shows an increase in hole carrier concentration in the diamond from 3.0 × 1012 to 1.8 × 1013 cm−2 at room temperature. High temperature Hall measurements performed up to 300 °C in atmosphere reveal greatly enhanced thermal stability of the hole channel produced using V2O5 in comparison with an air-induced surface conduction channel. Transfer doping of hydrogen-terminated diamond using high electron affinity oxides such as V2O5 is a promising approach for achieving thermally stable, high performance diamond based devices in comparison with air-induced surface transfer doping.
Adrenergically induced recurrent HSV-1 corneal epithelial lesions (1987)

Herpes simplex virus type 1 (HSV-1) ocular shedding and recurrent HSV-1 corneal epithelial lesions were assessed after ocular iontophoresis of 0.1% 6-hydroxydopamine followed by topical ocular instillation of 0.1% Propine in ten rabbits latently infected with HSV-1 strain McKrae. Iontophoresis was performed once at 0.5 mAmp for five minutes and 0.1% Propine drops were instilled four times a day beginning three days after iontophoresis and continuing for five consecutive days. Over an eight day period beginning three days after iontophoresis, ocular tear film samples were collected on Dacron swabs with care taken to avoid contact with the corneal epithelium. The corneas were examined daily for the presence of epithelial lesions using a slit-lamp biomicroscope. Three types of lesions were observed: deep punctate lesions, dendritic lesions, and geographic epithelial defects. The ratio of positive HSV-1 eye swabs to total eye swabs was 36/157 (23%). The ratio of total positive days of corneal lesions to total days was 40/160 (25%). There were 23 deep punctate lesions, 13 dendritic lesions, and four geographic epithelial defects. There were 24/36 (67%) positive HSV-1 eye swabs associated with concurrent HSV-1 corneal epithelial lesions. There were 105/121 (87%) negative eye swabs with concurrent negative slit-lamp examinations. Chi square analysis showed significant (p less than 0.001) association of HSV-1 positive eye swabs and HSV-1 corneal lesions. These results suggest that adrenergic ocular treatment may induce both HSV-1 ocular shedding (reactivation) and HSV-1 corneal epithelial lesions (recurrence) in rabbits latently infected with HSV-1 strain McKrae.
Industrial Rear Sin-Passivated Multicrystalline Silicon Solar Cells (2006)

The utilisation of progressively thinner wafers for solar cells leads to an increasing importance of rear surface passivation. In this work we investigate different solar cell processes for industrial rear side passivated solar cells using silicon nitride (SiN) on both sides and screen printed contacts. All solar cells were made by phosphorus emitter diffusion on p-type wafers. For a sufficient rear surface passivation, a parasitic rear emitter must be avoided. Therefore, we carefully compared different processes comprising rear SiN as barrier during phosphorus diffusion as well as parasitic emitter removal by etching after phosphorus diffusion. Furthermore two processes for rear side contacting through a silicon nitride layer were tested. The first process is firing of a screen printed aluminium grid through the backside SiN. The second process uses laser ablation to open a thick rear SiN followed by a full area screen printed rear contact. Additionally, a possible degradation of the SiN due to firing of aluminium contact fingers through the SiN layer was investigated using minority carrier lifetime topography before and after firing of the wafers. Efficiencies of up to 14.7% were obtained on 200 μm thick wafers using SiN layers on both sides. However, these processes are still excelled by the conventional solar cell process using a screen printed full area aluminium rear contact, which lead to an efficiency of 15.3% on a 200 μm thick neighbouring wafer.
Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques (2006)

The mechanism by which mechanical force regulates the kinetics of a chemical reaction is unknown. Here, we use single-molecule force-clamp spectroscopy and protein engineering to study the effect of force on the kinetics of thiol/disulfide exchange. Reduction of disulfide bonds through the thiol/disulfide exchange chemical reaction is crucial in regulating protein function and is known to occur in mechanically stressed proteins. We apply a constant stretching force to single engineered disulfide bonds and measure their rate of reduction by DTT. Although the reduction rate is linearly dependent on the concentration of DTT, it is exponentially dependent on the applied force, increasing 10-fold over a 300-pN range. This result predicts that the disulfide bond lengthens by 0.34 A at the transition state of the thiol/disulfide exchange reaction. Our work at the single bond level directly demonstrates that thiol/disulfide exchange in proteins is a force-dependent chemical reaction. Our findings suggest that mechanical force plays a role in disulfide reduction in vivo, a property that has never been explored by traditional biochemistry. Furthermore, our work also indicates that the kinetics of any chemical reaction that results in bond lengthening will be force-dependent.
An address data entry system with a multimodal interface including speech recognition (1999)

In this paper, improvement of the efficiency of data entry operations by adding a speech input function is reported. We implemented the multimodal interface on the desktop terminal for performance evaluation. An efficient and pleasant-to-use communication between man and machine is expected to result from the combination of speech input and a multimodal interface which can compensate for defects of speech recognition. In this paper, we apply the system to address data entry and evaluate its performances. Users can enter the address data by speech input, by menu selection from a display of ten words in one field, or by one-by-one selection display of the next candidate word, with input by keyboard. In the evaluation experiments, 25 operators performed 22,860 address data entry tasks and were instructed to use the speech input function in half of the tasks. From the evaluation results, the increase of operation time due to an increased number of entry data was reduced, and operation time was shortened by about 12% using the speech input function. The recognition rate of speech containing pauses is found to be significantly lower. © 1999 Scripta Technica, Syst Comp Jpn, 30(9): 64–73, 1999
Automated Library Generation Using Sequential Microwave-Assisted Chemistry. Application toward the Biginelli Multicomponent Condensation (2001)

The concept of automated sequential microwave-assisted library synthesis is introduced. For this purpose a dedicated single-mode microwave reactor with a robotics interface including a liquid handler and gripper was employed. The liquid handler allows dispensing of reagents into the Teflon sealed reaction vials, while the gripper moves each sealed vial in and out of the microwave cavity after irradiation. This technology was employed for the Biginelli three-component cyclocondensation reaction. A diverse set of 17 CH-acidic-carbonyl compounds (1A-Q), 25 aldehydes (2a-y), and 8 urea/thioureas (3alpha-varphi) was used in the preparation of a dihydropyrimidine (DHPM) library. Out of the full set of 3400 possible DHPM derivatives, a representative subset of 48 analogues was prepared using automated addition of building blocks and subsequent sequential microwave irradiation of each process vial. For most building block combinations 10 min of microwave flash heating at 120 degrees C using AcOH/EtOH (3:1) and 10 mol % Yb(OTf)(3) as solvent/catalyst system proved to be successful, leading to an average isolated yield of 52% of DHPMs with >90% purity. For some building block combinations the general conditions were modified, for example, by changing the solvent, catalyst, reaction temperature, or irradiation time. This flexibility is a distinct advantage of sequential over parallel microwave-assisted processes where all reactions are exposed to the same irradiation conditions. When the unattended automation capabilities of the microwave synthesizer are used, a library of this size can be synthesized within 12 h.