gebhart/patrepeval huggingface dataset:
Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model (2014)

Plasmacytoid dendritic cells (pDCs) have long been implicated in the pathogenesis of lupus. However, this conclusion has been largely based on a correlative link between the copious production of IFN-α/β by pDCs and the IFN-α/β "signature" often seen in human lupus patients. The specific contribution of pDCs to disease in vivo has not been investigated in detail. For this reason, we generated a strain of BXSB lupus-prone mice in which pDCs can be selectively depleted in vivo. Early, transient ablation of pDCs before disease initiation resulted in reduced splenomegaly and lymphadenopathy, impaired expansion and activation of T and B cells, reduced antibodies against nuclear autoantigens and improved kidney pathology. Amelioration of pathology coincided with decreased transcription of IFN-α/β-induced genes in tissues. PDC depletion had an immediate impact on the activation of immune cells, and importantly, the beneficial effects on pathology were sustained even though pDCs later recovered, indicating an early pDC contribution to disease. Together, our findings demonstrate a critical function for pDCs during the IFN-α/β-dependent initiation of autoimmune lupus and point to pDCs as an attractive therapeutic target for the treatment of SLE.
Review: <i>The Roaring Land</i>, by Archie Binns (1942)

Book Review| December 01 1942 Review: The Roaring Land, by Archie Binns The Roaring LandArchie Binns Charles M. Gates Charles M. Gates Search for other works by this author on: This Site PubMed Google Scholar Pacific Historical Review (1942) 11 (4): 465–466. https://doi.org/10.2307/3633272 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Charles M. Gates; Review: The Roaring Land, by Archie Binns. Pacific Historical Review 1 December 1942; 11 (4): 465–466. doi: https://doi.org/10.2307/3633272 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPacific Historical Review Search This content is only available via PDF. Copyright 1942 The Pacific Coast Branch, American Historical Association Article PDF first page preview Close Modal You do not currently have access to this content.
[Protective action of mexamine and indralin in intensive electromagnetic irradiation of rats]. (1995)

Protective properties of radioprotectors from indolyl alkylamine group (mexamine and indralin) in rats exposed to powerful electromagnetic irradiation (2.4 GHz, specific absorption rate 90-100 W/kg) was studied. The survival index of tested animals reached the maximum in condition of prophylactic administration of drugs in intervals 20-60 minutes before irradiation. Protective effect of mexamine and indralin connected with hypothermia and desensitization conditioned by the drugs use.
Regulation of REDD1 by insulin‐like growth factor‐I in skeletal muscle and myotubes (2009)

Insulin-like growth factor-I (IGF-I) is a major anabolic hormone for skeletal muscle and a potent stimulus for protein synthesis and translation initiation. Recent studies suggest that translation can be inhibited by over expression of the mammalian target of rapamycin (mTOR) repressor REDD1. The purpose of the present study was to determine whether IGF-I alters the expression of REDD1 and whether this is associated with a concomitant change in protein synthesis in vitro. Subcutaneous injection of IGF-I or intravenous delivery of insulin for 3-4 h increased REDD1 mRNA in skeletal muscle 7-10-fold. A threefold increase in REDD1 was observed when C2C12 myotubes were treated with IGF-I. REDD1 protein continued to be expressed for up to 24 h after addition of IGF-I to cells. Withdrawal of IGF-I from myotubes lead to a rapid loss of REDD1 protein content. IGF-I-induced REDD1 mRNA and protein expression were prevented by inhibitors of transcription and translation. IGF-I had an additive effect with dexamethasone (Dex) on REDD1 protein content in myotubes. The PI3K inhibitor LY294002 blocked IGF-I but not Dex induced REDD1. IGF-I also stimulated REDD1 promoter activity. Although REDD1 protein was elevated 5-6 h after addition of IGF-I to myotubes, protein synthesis measured during this 1 h window was paradoxically greater in myotubes expressing more REDD1. In contrast to the IGF-I induced increase in REDD1 mRNA, REDD2 mRNA was decreased by IGF-I. We conclude that IGF-I stimulates REDD1 expression in skeletal muscle and myotubes but under these conditions the REDD1 response is not sufficient to repress protein synthesis.
Deep ultraviolet microscope (1990)

A visible-light microscope has been modified to obtain deep UV (190-350-nm) images using reflected illumination. Potential advantages of deep UV microscopy include better resolution, depth of focus, and contrast for certain materials and fewer artifacts when viewing multilayered structures. These advantages are especially useful when viewing organic or semiconducting materials that are transparent or colored when viewed with visible light but are completely opaque when viewed using deep UV wavelengths. The hardware and optics of this microscope are described, and several uses are proposed for integrated circuit manufacture.
Large Diffraction Grating Ruling Engine With Nanometer Digital Control System (1987)

Modifications to the MIT-B grating ruling engine have recently been installed. In addition to a new ultra-quiet mechanical drive system for the diamond carriage an entirely new digital servo control system has been installed. It operates with a bit size of 0.09 nm, with virtually infinite control levels. Rowland ghost levels are no longer detectable, which implies that periodic error amplitudes are below 0.5 nm.
Whitening Effects of Angelica dahurica Radix Ethanol Extract (2011)

본 논문은 백지 에탄올추출물의 미백효능을 조사하기 위하여 melan-a cell, 브라운 기니피그 및 HMB-45 염색을 사용하였다. melan-a 세포에 시료를 6.25, 12.5, 25, 50, <TEX>${\mu}g/m{\ell}$</TEX> 농도로 처치하여 세포 생장율의 변화 관찰 및 멜라닌세포의 형태학적 변화를 관찰하였다. 또한 brown guinea pig (450~500 g)등 부위에 1500 mJ/<TEX>$cm^2$</TEX> 광량의 ultraviolet B조사로 유발시킨 인공색소반 (<TEX>${\Phi}$</TEX> 2 mm)에 1일 2회, 주 5일, 매회 30 <TEX>${\mu}{\ell}$</TEX>씩 총 5주간 시료를 도포하여 주 1회 육안적 변화를 관찰 하였고, 실험 5주째 되는 날 실험동물은 염산 케타민으로 마취 후 시료를 도포한 인공색소반 부위를 biopsy punch로 절취하여 HMB-45 염색으로 멜라닌소체 내 glycoprotein(gp100) 단백질의 조직학적 변화를 관찰 하였다. 세포생장율 측정에서 시료처치 6.25~50 <TEX>${\mu}g/m{\ell}$</TEX>에서의 세포생장율은 높았고, 멜라닌세포의 형태학적 변화에서는 시료처치 농도가 증가할수록 멜라닌합성 및 수지상 돌기가 적게 관찰 되었다. 동물 실험 육안적 관찰에서 시료 도포군이 용매대조군에 비해 멜라닌 색소침착 정도가 확연하게 밝아졌고, gp100 단백질의 조직학적 관찰에서 시료 도포군은 gp100 단백질 발현 정도가 현저하게 줄어들었으며, 영상분석에서도 시료 도포군이 용매대조군에 비해 유의하게(p<0.001) 감소하였는데 이러한 결과는 현미경 관찰 결과와 일치하였다. 이상의 결과를 종합하면 백지 에탄올추출물은 우수한 미백효과가 있는 것으로 판단된다. To investigate whitening Effects of Angelica dahurica Radix Ethanol Extract (ADEE), we used melan-a cell line, brown guinea pig, and HMB-45. We treated with ADEE of 6.25, 12.5, 25, and 50 <TEX>${\mu}g/m{\ell}$</TEX> concentration in order to evaluate the effect of ADEE on cell viability and on morphological observation of melan-a cells. Also we were induced the artificial tanning spots by 1,500 mJ/<TEX>$cm^2$</TEX> of ultraviolet B radiation on the backs of brown guinea pigs (approximately 450~500g) and then the test agent of <TEX>$30{\mu}{\ell}$</TEX> was applied on the spots twice a day, five days a week, for five weeks respectively. The visible whitening effect was evaluated once a week. At the end of the experiment, the animals were sacrificed under anesthetization. The artificial tanning spots were obtained by biopsy punch and stained with HMB-45 to observe the gp100 proteins which were melanosomes. Our results show that cell viability was not reduce at ADEE concentrations between 6.25 and 50 <TEX>${\mu}g/m{\ell}$</TEX>, melanin synthesis and melanocyte dendricity were decreased in ADEE treated melan-a cells increasing ADEE concentration. In the gross observation, ADEE treated groups had lower pigmentation than the vehicle control groups. And in the histological observation, ADEE treated groups had lower melanocytes than the vehicle control groups. Also in the quantitative analysis of the gp100 proteins using image analysis software, ADEE treated groups had a significantly lower value (p<0.001) than the vehicle control group and this resultsagreed with the results of observation under microscope. From these results, weconcluded that ADEE had positive whitening effect.
Novel method for characterisation of single-mode fibres and prediction of crossover wavelength and bandpass in nonidentical fibre directional couplers (1986)

We present here a novel and accurate method for the characterisation of single-mode fibres from a measurement of the wavelength dependence of the Petermann spot size. We also show its applicability in the prediction of the crossover wave length and bandpass in wavelength filters using nonidentical fibre directional couplers.
Specific Problems of Sampling and Measuring Diesel Exhaust Emissions (1988)

<div class="htmlview paragraph">The results of emission and fuel economy tests on vehicles are still subject to serious errors. Unclear definitions and inadequately specified test procedures and testing equipment together with insufficient methods of calibration are the main reasons for this unpleasant fact.</div> <div class="htmlview paragraph">Improvements to the situation would only be made possible by improving the test procedures. Fundamental proposals for doing this exist. However, all efforts regarding this are useful only if the authorities are willing to accept such improvements, to put them into use themselves and to incorporate them into the pertinent regulations.</div> <div class="htmlview paragraph">Further investigations are necessary to ensure that test procedures will yield credible results as well as being generally applicable and not merely applicable to particular concepts.</div>
On Linear Skewing Schemes and d-Ordered Vectors (1987)

Linear skewing schemes were introduced by Kuck et al. in the nineteen sixties, to provide a simple class of storage mappings for N × N matrices for use in vector processors with a large number of memory banks. Conditions on linear skewing schemes that guarantee conflict-free access to rows, columns, and/or (anti-) diagonals are usually presented in terms of conditions on so-called d-ordered vectors. We shall argue that these formulations are mathematically imprecise, and revise and extend the existing theory. Several claims are proved to bound the minimum number of memory banks needed for successful linear skewing by, e.g., the smallest prime number ≥ N.
Slurries of solid carboniferous fuels. [Equipment] (1973)

Short-term administration of darbe did not affect the ANCs of preterm neonates treated for anemia of prematurity. There was no difference in the rates of occurrence of neutropenia, severe neutropenia, or resolution of either between the darbe-treated neonates and comparator neonates.
A Polysilicon Flow Sensor For Gas Flowmeters (2005)

We have developed a one-wire type thermal flow sensor that has a polysilicon microheater. It has very wide flow measurement range of 0.005-35m/s and very short response time of 0.14ms (90%). The size of the flow sensor chip is 1mm x 1mm x O.3mm. The sensitivity is above 22mV/(m/s)/sup 1/2/ when it is operated by constant resistance mode. Consuming electric power to keep the temperature rise of the microheater 80K in windless air at 22/spl deg/C under atmospheric pressure is about 6mW. As the polysilicon has large resistivity, large output signals can be gotten without amplifiers. It can be applied to household gas flowmeters and other systems.
Salivary Defense Factors in Herpes Simplex Virus Infection (2002)

Saliva may contribute to a lowering of the infectious herpes simplex virus (HSV) dose during transmission and consequently abrogate infection or lead to decreased reactivation. To test this hypothesis, we assayed saliva for innate defense factors, immunoglobulin content, and the capacity to interfere with HSV infection. Serum or salivary anti-HSV IgG levels did not correlate with control of recurrent labial herpes (RLH) and were significantly higher in subjects with RLH compared with asymptomatic seropositive subjects. Although no differences in levels or output rate of innate defense factors between the groups were observed, the salivary neutralizing activity correlated with lactoferrin and hypothiocyanite concentrations in the asymptomatic seropositive group. Our results suggest that saliva contains factors, in addition to anti-HSV immunoglobulins, that neutralize HSV and may indirectly contribute to the control of RLH.
Gene Transfer of a Cell Cycle Modulator Exerts Anti-Inflammatory Effects in the Treatment of Arthritis (2003)

Forced expression of a cyclin-dependent kinase inhibitor gene, p21(Cip1) in the synovial tissues was effective in treating animal models of rheumatoid arthritis. Synovial hyperplasia in the treated joints was suppressed, reflecting the inhibitory effect of p21(Cip1) on cell cycle progression. Additionally, lymphocyte infiltration, expression of inflammatory cytokines, and destruction of the bone and cartilage were inhibited. To determine why the cell cycle regulator gene exerted such anti-inflammatory effects, we investigated gene expression by rheumatoid synovial fibroblasts with or without the p21(Cip1) gene transferred. We have found that p21(Cip1) gene transfer down-regulates expression of various inflammatory mediators and tissue-degrading proteinases that are critically involved in the pathology of rheumatoid arthritis. These molecules included IL-6, -8, type I IL-1R (IL-1R1), monocyte chemoattractant protein-1, macrophage inflammatory protein-3alpha, cathepsins B and K, and matrix metalloproteinases-1 and -3. Down-regulation of IL-1R1 by p21(Cip1) resulted in attenuated responsiveness to IL-1. Inhibition of the inflammatory gene expression by p21(Cip1) was seen even when IL-1 is absent. This IL-1R1-independent suppression was accompanied by reduced activity of c-Jun N-terminal kinase, which was associated with p21(Cip1), and inactivation of NF-kappaB and AP-1. These multiple regulatory effects should work in concert with the primary effect of inhibiting cell cycle in ameliorating the arthritis, and suggest a heretofore unexplored relationship between cyclin-dependent kinase inhibitor gene and inflammatory molecules.
Root-law circuit using monolithic bipolar-transistor arrays (1974)

Close matching in the respective parameters of bipolar transistors fabricated on the same monolithic chip facilitates the design of a circuit characterised bywhere I0 is the output current, I1, ‥, Im are input currents and n (≥1) is an integral number. Experimental measurements for n=2, m=3 and 1 μA ≤ Ir ≤ 1 mA are presented and discussed in relation to a simple theoretical error formula.
Melatonin Reduces Oxidative Stress Induced by Chronic Exposure of Microwave Radiation from Mobile Phones in Rat Brain (2008)

We demonstrated two important findings; that mobile phones caused oxidative damage biochemically by increasing the levels of MDA, carbonyl groups, XO activity and decreasing CAT activity; and that treatment with the melatonin significantly prevented oxidative damage in the brain.
Context-Aware Mobile Web Browsing Based on HTML5 (2012)

Internet is steaming with a great variety of information including instant news, music, advertisement, etc. However, users will be overwhelmed by too much information presented on web page at once. In this paper, we propose a context-aware mobile web browsing system to reduce user distraction and ultimately enhance user experience. First, we capture user context such as time and location information through sensors embedded in mobile phones. Second, we recommend relevant information and adapt the web page according to user profile and current context. We implement a prototype of context-aware web information access by leveraging HTML5.
A four‐channel time domain multiplexer: A cost‐effective alternative to multiple receivers (1994)

The concept of simultaneous image acquisition as originally conceived by Hyde has been implemented by Roemer et al. using a multiple receiver system. This article describes an alternative technique that uses time domain multiplexing (TDM) to acquire simultaneous images using a single receiver channel. This method requires few modifications to the existing receiver and has been shown to be equivalent to a true four channel receiver in most applications. The multiplexing technique was implemented and tested on a standard commercial scanner that has also been equipped with a four channel receiver. Signal-to-noise results demonstrate that four independent images can be multiplexed through a single receiver channel with no degradation in image quality. Additionally, spine images that were obtained from a normal volunteer with both a multiplexed single channel receiver and a true four channel receiver system are presented.
Clinical approach to treatable inborn metabolic diseases: An introduction (2006)

In view of the major improvements in treatment, it has become increasingly important that in order for first-line physicians not to miss a treatable disorder they should be able initiate a simple method of clinical screening, particularly in the emergency room. We present a simplified classification of treatable inborn errors of metabolism in three groups. Group 1 includes inborn errors of intermediary metabolism that give rise to an acute or chronic intoxication. It encompasses aminoacidopathies, organic acidurias, urea cycle disorders, sugar intolerances, metal disorders and porphyrias. Clinical expression can be acute or systemic or can involve a specific organ, and can strike in the neonatal period or later and intermittently from infancy to late adulthood. Most of these disorders are treatable and require the emergency removal of the toxin by special diets, extracorporeal procedures, cleansing drugs or vitamins. Group 2 includes inborn errors of intermediary metabolism that affect the cytoplasmic and mitochondrial energetic processes. Cytoplasmic defects encompass those affecting glycolysis, glycogenosis, gluconeogenesis, hyperinsulinisms, and creatine and pentose phosphate pathways; the latter are untreatable. Mitochondrial defects include respiratory chain disorders, and Krebs cycle and pyruvate oxidation defects, mostly untreatable, and disorders of fatty acid oxidation and ketone bodies that are treatable. Group 3 involves cellular organelles and includes lysosomal, peroxisomal, glycosylation, and cholesterol synthesis defects. Among these, some lysosomal disorders can be efficiently treated by enzyme replacement or substrate reduction therapies. Physicians can be faced with the possibility of a treatable inborn error in an emergency, either in the neonatal period or late in infancy to adulthood, or as chronic and progressive symptoms--general (failure to thrive), neurological, or specific for various organs or systems. These symptoms are summarized in four tables. In addition, an extensive list of medications used in the treatment of inborn errors is presented.
Synchronous rotation of a floating magnet and flux penetration in Y-Ba-Cu-O superconductor (1989)

An experimental demonstration of induced rotation of a rectangular magnet floating above a superconducting ring is described. Synchronism between the rotating and the applied alternating magnetic field was observed under certain conditions. The stability of the levitated magnet and the mechanism of the rotation are discussed on the basis of the authors' studies of flux penetration into superconductors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
PredRNN: recurrent neural networks for predictive learning using spatiotemporal LSTMs (2017)

The predictive learning of spatiotemporal sequences aims to generate future images by learning from the historical frames, where spatial appearances and temporal variations are two crucial structures. This paper models these structures by presenting a predictive recurrent neural network (PredRNN). This architecture is enlightened by the idea that spatiotemporal predictive learning should memorize both spatial appearances and temporal variations in a unified memory pool. Concretely, memory states are no longer constrained inside each LSTM unit. Instead, they are allowed to zigzag in two directions: across stacked RNN layers vertically and through all RNN states horizontally. The core of this network is a new Spatiotemporal LSTM (ST-LSTM) unit that extracts and memorizes spatial and temporal representations simultaneously. PredRNN achieves the state-of-the-art prediction performance on three video prediction datasets and is a more general framework, that can be easily extended to other predictive learning tasks by integrating with other architectures.
RQL: Global Placement via Relaxed Quadratic Spreading and Linearization (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Strategies for Positioning Fluorescent Probes and Crosslinkers on Formyl Peptide Ligands (1998)

Chemoattractant receptors represent a major subset of the G-protein coupled receptor (GPCR) family. One of the best characterized, the N-formyl peptide receptor (FPR), participates in host defense responses of neutrophils. The features of the ligand which regulate its interaction with the FPR are well-known. By manipulating these features we have developed new ligands to probe structural and mechanistic aspects of the peptide-receptor interaction. Three ligand groups have been developed: 1) ligands containing a Lys residue located in positions 2 through 7 that can be conjugated to FITC (N-formyl-Met1-Lys2-Phe3-Phe4, N-formyl-Met1-Leu2-Lys3-Phe4, N-formyl-Met1-Leu2-Phe3-Lys4, N-formyl-Met1-Leu2-Phe3-Phe4-Lys5, N-formyl-nLeu1-Leu2-Phe3-nLeu4-Tyr5-Lys6 and N-formyl-Met1-Leu2-Phe3-Phe4-Gly5-Gly6-Lys7; 2) fluorescent pentapeptide ligands (N-formyl-Met-X-Phe-Phe-Lys(FITC) where X = Leu, Ala, Val or Gly); and 3) small crosslinking ligands where the photoaffinity crosslinker 4-azidosalicylic acid (ASA) was conjugated to Lys in positions 3 and 4 and p-benzoyl-phenylalanine (Bpa) was located in position 2 in N-formyl-Met1-Bpa2-Phe3-Tyr4. The peptides were characterized according to activity and affinity in human neutrophils and cell lines transfected with FPR. All of the peptides were agonists, with parallel affinity and activity. In the first group, the peptide activity decreases as Lys is placed closer to the N-formyl group and the activity is improved by 1-3 orders of magnitude by conjugation with FITC. In the second group, the dissociation rate of the peptide from the receptor increases as position 2 is replaced by aliphatic amino acids with smaller alkyl groups. In the third group, crosslinking ligands remain biologically active, display nM affinity and covalently label the FPR.