gebhart/patrepeval huggingface dataset:
Glycosyl-Nucleolipids as New Bioinspired Amphiphiles (2013)

Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lower glim) compared to the first generation of GNFs.
Mg/Al Ordering in Layered Double Hydroxides Revealed by Multinuclear NMR Spectroscopy (2008)

The anion-exchange ability of layered double hydroxides (LDHs) has been exploited to create materials for use in catalysis, drug delivery, and environmental remediation. The specific cation arrangements in the hydroxide layers of hydrotalcite-like LDHs, of general formula Mg2+(1-x)Al3+(x)OH2(Anion(n-)(x/n)).yH2O, have, however, remained elusive, and their elucidation could enhance the functional optimization of these materials. We applied rapid (60 kilohertz) magic angle spinning (MAS) to obtain high-resolution hydrogen-1 nuclear magnetic resonance (1H NMR) spectra and characterize the magnesium and aluminum distribution. These data, in combination with 1H-27Al double-resonance and 25Mg triple-quantum MAS NMR data, show that the cations are fully ordered for magnesium:aluminum ratios of 2:1 and that at lower aluminum content, a nonrandom distribution of cations persists, with no Al3+-Al3+ close contacts. The application of rapid MAS NMR methods to investigate proton distributions in a wide range of materials is readily envisaged.
Mobile IP Technology and Applications (2005)

Real-world solutions for Cisco IOS® Mobile IP configuration, troubleshooting, and management Understand the concept of mobility and the requirements of mobility protocols Learn necessary components of a Mobile IP network, including features, functions, and message flows Examine security concepts related to Mobile IP, including protocol authentication and dynamic keying Evaluate high availability solutions and integration with AAA servers in campus networks Explore the features of metro mobility, including reverse tunneling, firewall, NAT traversal, and integration with VPN technologies Configure IOS Mobile IP networks, including integration topics such as redundancy, QoS, and VPN Manage the Mobile IP infrastructure, including Home Address management, scalability considerations, and network management Take a look at the future of Mobile IP, including Layer 2 integration challenges, Mobile IPv6, unstructured mobility, and mobile ad-hoc networkingTwo of the world's most powerful technology trends, the Internet and mobile communications, are redefining how and when people access information. With the majority of information and new services being deployed over IP, the use of devices such as cellular phones, PDAs, and laptops for accessing data networks is pushing the need for “always on” IP connectivity. The evolution of mobile computing points to a coming together of the best of desktop computing and cellular communications-the predictability and always connected experience of the desktop combined with the ease of use and mobility of the cell phone.One challenge to mobile data communication is moving data across different networks. The solution to this problem is a standards-based protocol: Mobile IP. Mobile IP is an open standard that allows users to keep the same IP address, stay connected, and maintain ongoing applications while roaming between IP networks.Mobile IP Technology and Applications is the first book to address the practical application of Mobile IP in real-world environments. Cisco IOS® Mobile IP configuration, troubleshooting, and management are covered in depth and supported by real-world examples. Mobility solutions addressed in this book include enterprise campus wireless LANs and metropolitan mobility for both individual devices and whole networks. Each example is designed to teach configuration, management, and troubleshooting in a manner that is directly applicable to common mobility needs.Whether you are looking for an introduction to IP mobility or detailed examples of Mobile IP technology in action, Mobile IP Technology and Applications is your complete resource for reaping the benefits that secure, reliable mobile communications have to offer.IP Mobility provides the capability not only for me to connect to the world at large, but for it to find and connect to me.-Fred Baker, Cisco Fellow, Cisco Systems, Inc.This book is part of the Cisco Press® Networking Technology Series, which offers networking professionals valuable information for constructing efficient networks, understanding emerging technologies, and building successful networking careers.
[Possible relationship of the function of dysbindin-1 with the pathophysiology of schizophrenia]. (2011)

Schizophrenia is a psychiatric disorder with a prevalence of about 1%. Genetic factors are known to be important in the etiology of schizophrenia and several susceptibility genes have been identified in linkage or association studies. Although the pathophysiology is yet to be determined, unusual neurotransmissions such as dopaminergic and glutamatergic systems have been suggested for the mechanism of schizophrenia symptoms. On the other hand, the concept that schizophrenia is a neurite malformation illness has arisen, based on the observations that DISC1 is involved in neuronal development. The gene for dysbindin-1 (DTNBP1) is situated at chromosome 6, the location of one of the most established linkages to schizophrenia. Interestingly, significant haplotypic associations between DTNBP1 and schizophrenia have been found in several studies in independent populations of schizophrenic cases. In addition, reduction of the gene and the protein of dysbindin-1 have been reported in brains from schizophrenic cases. Hence, genetic variations in DTNBP1 might be a major risk factor for schizophrenia. In the present review, we focus on the function of dysbindin-1 and its potential contributions to the pathophysiology of schizophrenia.
Agrin Binds to the N-terminal Region of Lrp4 Protein and Stimulates Association between Lrp4 and the First Immunoglobulin-like Domain in Muscle-specific Kinase (MuSK) (2011)

Neuromuscular synapse formation depends upon coordinated interactions between motor neurons and muscle fibers, leading to the formation of a highly specialized postsynaptic membrane and a highly differentiated nerve terminal. Synapse formation begins as motor axons approach muscles that are prepatterned in the prospective synaptic region in a manner that depends upon Lrp4, a member of the LDL receptor family, and muscle-specific kinase (MuSK), a receptor tyrosine kinase. Motor axons supply Agrin, which binds Lrp4 and stimulates further MuSK phosphorylation, stabilizing nascent synapses. How Agrin binds Lrp4 and stimulates MuSK kinase activity is poorly understood. Here, we demonstrate that Agrin binds to the N-terminal region of Lrp4, including a subset of the LDLa repeats and the first of four β-propeller domains, which promotes association between Lrp4 and MuSK and stimulates MuSK kinase activity. In addition, we show that Agrin stimulates the formation of a functional complex between Lrp4 and MuSK on the surface of myotubes in the absence of the transmembrane and intracellular domains of Lrp4. Further, we demonstrate that the first Ig-like domain in MuSK, which shares homology with the NGF-binding region in Tropomyosin Receptor Kinase (TrKA), is required for MuSK to bind Lrp4. These findings suggest that Lrp4 is a cis-acting ligand for MuSK, whereas Agrin functions as an allosteric and paracrine regulator to promote association between Lrp4 and MuSK.
A rapid prototyping technique for the fabrication of solvent-resistant structures (2003)

We demonstrate a rapid prototyping technique for the fabrication of solvent-resistant channels up to and exceeding one millimeter in height. The fabrication of channels with such dimensions by conventional lithography would be both challenging and time consuming. Furthermore, we show that this technology can be used to fabricate channels with a depth that varies linearly with distance. This technique requires only a long-wavelength ultraviolet source, a mask made by a desktop printer and a commercially available optical adhesive. We demonstrate two lithographic methods: one that fabricates channels sealed between glass plates (close-faced) and one that fabricates structures on a single plate (open-faced). The latter is fully compatible with silicon replication techniques to make fluid handling devices.
Using fourth order element for free vibration parametric analysis of thick plates resting on elastic foundation (2018)

The purpose of this paper is to study free vibration analysis of thick plates resting on Winkler foundation using Mindlin\'s theory with shear locking free fourth order finite element, to determine the effects of the thickness/span ratio, the aspect ratio, subgrade reaction modulus and the boundary conditions on the frequency paramerets of thick plates subjected to free vibration. In the analysis, finite element method is used for spatial integration. Finite element formulation of the equations of the thick plate theory is derived by using higher order displacement shape functions. A computer program using finite element method is coded in C++ to analyze the plates free, clamped or simply supported along all four edges. In the analysis, 17-noded finite element is used. Graphs are presented that should help engineers in the design of thick plates subjected to earthquake excitations. It is concluded that 17-noded finite element can be effectively used in the free vibration analysis of thick plates. It is also concluded that, in general, the changes in the thickness/span ratio are more effective on the maximum responses considered in this study than the changes in the aspect ratio.
The development of machine vision for road vehicles in the last decade (2003)

Machine vision for road vehicles started in the mid-80s. After a very brief review of the initial phase of about half a decade, developments over the last decade are discussed in more detail. The EUREKA-project 'Prometheus' set the stage in Europe and spread activities to all major carmakers and to many universities throughout Europe. The US and some Asian countries soon followed The basic perceptual and behavioral capabilities for driving and for driver assistance on well-kept high-speed roads have been demonstrated at the end of the Prometheus project. Later developments took two directions: 1. Simple systems for early application in confined domains, and 2. more complex systems with growth potential for performance levels closer to the human one. In the meantime, first products with machine vision components are on the market; more highly integrated systems have been announced for the second half of this decade. A road map for the development of vision for cars is discussed.
Temporal-Clustering Invariance in Irregular Healthcare Time Series (2019)

Electronic records contain sequences of events, some of which take place all at once in a single visit, and others that are dispersed over multiple visits, each with a different timestamp. We postulate that fine temporal detail, e.g., whether a series of blood tests are completed at once or in rapid succession should not alter predictions based on this data. Motivated by this intuition, we propose models for analyzing sequences of multivariate clinical time series data that are invariant to this temporal clustering. We propose an efficient data augmentation technique that exploits the postulated temporal-clustering invariance to regularize deep neural networks optimized for several clinical prediction tasks. We introduce two techniques to temporally coarsen (downsample) irregular time series: (i) grouping the data points based on regularly-spaced timestamps; and (ii) clustering them, yielding irregularly-paced timestamps. Moreover, we propose a MultiResolution Ensemble (MRE) model, improving predictive accuracy by ensembling predictions based on inputs sequences transformed by different coarsening operators. Our experiments show that MRE improves the mAP on the benchmark mortality prediction task from 51.53% to 53.92%.
Desfontaines travesti : une « Dame angloise » traduit les Avantures de Joseph Andrews de Fielding (1743) (2004)

À partir de l’analyse de certains éléments du paratexte de la première traduction française d’un texte de Henry Fielding, soit Les Avantures de Joseph Andrews, et du ministre Abraham Adams de Pierre-François Guyot Desfontaines, cet article montre comment la censure, entendue dans tous les sens que ce terme prend à l’époque, influe sur la traduction et, simultanément, comment Desfontaines répond, dans le paratexte de sa traduction et dans d’autres textes, au phénomène de la censure. L’ensemble du paratexte du Joseph Andrews français semble faire appel à une série de procédés associés, au XVIII e siècle, aux mécanismes de la censure politique et littéraire, qu’on lui donne le sens de critique ou d’interdiction d’un ouvrage. Le personnage de « La Dame Angloise » assumé par Desfontaines, critique dans ses « notes » et dans sa « Lettre » les usages décrits par Fielding et, par la même occasion, les coutumes de sa propre nation. De tels commentaires visent normalement à défendre le texte et les choix du traducteur contre les attaques des critiques et censeurs trop épris de morale.
Considering Abundance, Affinity, and Binding Site Availability in the NF-κB Target Selection Puzzle (2019)

The NF-κB transcription regulation system governs a diverse set of responses to various cytokine stimuli. With tools from <i>in vitro</i> biochemical characterizations, to omics-based whole genome investigations, great strides have been made in understanding how NF-κB transcription factors control the expression of specific sets of genes. Nonetheless, these efforts have also revealed a very large number of potential binding sites for NF-κB in the human genome, and a puzzle emerges when trying to explain how NF-κB selects from these many binding sites to direct cell-type- and stimulus-specific gene expression patterns. In this review, we surmise that target gene transcription can broadly be thought of as a function of the nuclear <i>abundance</i> of the various NF-κB dimers, the <i>affinity</i> of NF-κB dimers for the regulatory sequence and the <i>availability</i> of this regulatory site. We use this framework to place quantitative information that has been gathered about the NF-κB transcription regulation system into context and thus consider questions it answers, and questions it raises. We end with a brief discussion of some of the future prospects that new approaches could bring to our understanding of how NF-κB transcription factors orchestrate diverse responses in different biological contexts.
The Relaxation Response (1974)

When Dr. Herbert Benson introduced this simple, effective, mind/body approach to relieving stress twenty-five years ag, his book became an instant national bestseller. Since that time, millions of people have learned the secret--without high-priced lectures or prescription medicines. The Relaxation Response has become the classic reference recommended by most health care professionals and authorities to treat the harmful effects of stress.Discovered by Dr. Benson and his colleagues in the laboratories of Harvard Medical School and its teaching hospitals, this revitalizing, therapeutic approach is now routinely recommended to treat patients suffering from heart conditions, high blood pressure, chronic pain, insomnia, and many other physical ailments. It requires only minutes to learn, and just ten to twenty minutes of practice twice a day.
Fetal Electrocardiography (1963)

This study in fetal electrocardiography was undertaken to evaluate the clinical accuracy of a simple, inexpensive preamplifier and a standard electrocardiograph. Two hundred and fifty-four patients were studied. These were divided into three groups. In group 1, consisting of 200 patients with normal pregnancy, positive fetal electrocardiograms (ECG) were recorded in 179 (89.5%), including one set of clinically unsuspected twins. In group 2, of ten patients in normal active labor, positive tracings were obtained in all ten between uterine contractions and in nine during contractions as well. Group 3 consisted of 44 diagnostic problem patients (suspected fetal death, twin pregnancy, pseudocyesis, hydatid mole, and arrhythmia); fetal electrocardiography established a correct diagnosis in 42 cases (95%).
Achieving RGD resistance to meet current oilfield needs (2011)

Seal damage and observed gas leaks into the atmosphere caused by rapid gas decompression (RGD) in elastomeric seals have been reported in many types of equipment used in the oil and gas industry. These failures can have costly financial, safety and environmental implications for operators and equipment suppliers. This article looks at RGD in general and the implications of Norsok standards, developed by the Norwegian petroleum industry, for RGD testing and sour gas ageing of elastomers and thermoplastics.
A Digital Multi-Mode Multi-Phase IC Controller for Voltage Regulator Application (2007)

This paper presents a digital multi-mode multi-phase IC controller for the voltage regulator application. The IC controller combines load current feedforward with a load-scheduled digital PID feedback control to achieve a fast load transient response. The multi-mode control strategy is applied in the designed controller IC, allowing high efficiency operation of a voltage regulator over a wide load range. A high resolution 13-bit digital pulse width modulator (DPWM) and 4mV quantization bin analog-to-digital converter (ADC) is implemented in the IC controller to ensure tight DC regulation of the regulator. The prototype 4-phase IC controller takes 0.5 mm2 active area in a 0.18 μm CMOS process.
Theoretical foundations for multiple rendezvous of glowworm-inspired mobile agents with variable local-decision domains (2006)

We present the theoretical foundations for the multiple rendezvous problem involving design of local control strategies that enable groups of visibility-limited mobile agents to split into subgroups, exhibit simultaneous taxis behavior towards, and eventually rendezvous at, multiple unknown locations of interest. The theoretical results are proved under certain restricted set of assumptions. The algorithm used to solve the above problem is based on a glowworm swarm optimization (GSO) technique, developed earlier, that finds multiple optima of multimodal objective functions. The significant difference between our work and most earlier approaches to agreement problems is the use of a virtual local-decision domain by the agents in order to compute their movements. The range of the virtual domain is adaptive in nature and is bounded above by the maximum sensor/visibility range of the agent. We introduce a new decision domain update rule that enhances the rate of convergence by a factor of approximately two. We use some illustrative simulations to support the algorithmic correctness and theoretical findings of the paper
Effect of Force-Feeding Upon Basal Insulin Levels of Rats (1975)

Rats were over- or under-fed to achieve a wide range of body weights. The effect of this treatment on basal insulin levels, with and without pretreatment with atropine, was examined. Basal insulin was positively correlated with body weight and this relationship was essentially unchanged in the presence of atropine.
Olefin Polymerization Catalyzed by Titanium−Tungsten Heterobimetallic Dinitrogen Complexes<sup>1</sup> (2004)

A new family of highly active olefin polymerization catalysts based on titanium−tungsten heterobimetallic dinitrogen complexes, [Cp'TiCl2(μ-N2)WCl(L)4] (1; L = PMe2Ph, 1/2 R2PCH2CH2PR2; R = Et, Ph), has been developed, in which the tungsten dinitrogen fragment acts as a novel metallonitrogen ligand to the catalytically active titanium center. Alkylation of 1d (Cp' = C5Me5, L = 1/2 Et2PCH2CH2PEt2) with MeLi gave di- and trimethyl derivatives 2d and 3d, which were structurally characterized.
Imaging nonlinear scatterers applying the time reversal mirror (2006)

Nonlinear elastic wave spectroscopy (NEWS) has been shown to exhibit a high degree of sensitivity to both distributed and isolated nonlinear scatterers in solids. In the case of an isolated nonlinear scatterer such as a crack, by combining the elastic energy localization of the time reversal mirror with NEWS, it is shown here that one can isolate surfacial nonlinear scatterers in solids. The experiments presented here are conducted in a doped glass block applying two different fixed frequency time-reversed signals at each focal point and scanning over a localized nonlinear scatterer (a complex crack). The results show a distinct increase in nonlinear response, via intermodulation distortion, over the damaged area. The techniques described herein provide the means to discriminate between linear and nonlinear scatterers, and thus to ultimately image and characterize damaged regions.
The IC design of a high speed RSA processor (2002)

In this paper, we proposed a new algorithm based on Montgomery's algorithm to calculate modular multiplication that is the core arithmetic operation in RSA cryptosystem. Since the critical path delay in modular multiplication operation is reduced, the new design yields a very fast implementation. We have implemented a 512-bit single chip RSA processor based on our modified algorithm with Compass 0.6 /spl mu/m SPDM cell library. By our modified modular exponentiation algorithm, it takes about 1.5 n/sup 2/ clock cycles to finish one n-bit RSA modular exponentiation operation in our architecture. The simulation results show that we can operate up to 125 Mhz, therefore the baud rate of our 512-bit RSA processor is about 164 k bits/sec.
Operating Electrical Submersible Pumps Below the Perforations (1998)

Summary The electrical submersible pump (ESP) uses the flow of well fluid to cool the motor. This, traditionally, has been done by landing the ESP above the perforations or by using a shroud to redirect the fluid around the motor. This paper examines some of the advantages and disadvantages of ESP operation below the perforation. Several equipment options necessary for this type of operation are presented, along with an operator's field experience where below-perforation operation looked to be advantageous.
Creepers : British horror and fantasy in the twentieth century (1993)

Introduction imperial horror fiction Henry Hope Hodgson Arthur Machen H.G. Wells M.R. James Daphne du Maurier Dennis Wheatley C.S. Lewis Henry James Ramsay Campbell Clive Barker James Herbert.
An ultra high speed test system (1989)

The test-head subsystem presented uses gallium arsenide pin electronics to provide nonrepeating zero data rates up to 1.2 Gb/s. The device under test is connected to laser-scanned optical sensors, and the test system receivers use an electrooptic measurement method to capture the pin information. The receiver has a 4.5-GHz bandwidth and can perform functional test at the emitter-coupled logic level with one sampling pulse per vector. The device environment supports signals bandwidths near 5 GHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>