gebhart/patrepeval huggingface dataset:
Ambulatory medical care utilization estimates for 2006. (2008)

Patients in the United States made an estimated 1.1 billion visits to physician offices and hospital OPDs and EDs, a rate of 381.9 visits per 100 persons annually. The overall visit rate was not significantly different for white and black persons. However, black persons had higher visit rates than white persons to hospital OPDs and EDs and lower visit rates to office-based surgical and medical specialists. Visit distribution by ambulatory care setting differed by poverty level in the patient's ZIP Code of residence, with higher proportions of visits to hospital OPDs and EDs as poverty levels increased. Between 1996 and 2006, visit rates to medical specialty offices climbed overall by 29 percent, with a significant increase noted for white patients but not black patients. The rate of OPD visits jumped from 25.4 visits per 100 persons in 1996 to 34.7 in 2006, whereas ED visits during the same period increased from 34.1 to 40.5 per 100 persons. About 18.3 percent of all ambulatory care visits in 2006 were for nonillness or noninjury conditions, such as routine checkups and pregnancy exams. Seven in ten ambulatory care visits had at least one medication provided, prescribed, or continued in 2006, for a total of 2.6 billion drugs overall. Analgesics were the most common therapeutic category, accounting for 13.6 drugs per 100 drugs prescribed, and they were most often utilized at primary care and ED visits. The percentage of visits at which medication was prescribed increased significantly in most settings between 1996 and 2006.
Stability and response of closed loop directional drilling system using linear delay differential equations (2011)

A directionally controlled drilling mechanism has a lateral borehole propagation equation of state composed of spatially delayed feedback terms determined by the distribution of contact points between the borehole and drilling mechanism. A lateral borehole propagation equation is developed for a generic class of steering system. After simplification the resulting linear delay differential equation is partially validated against a Finite Element Model (FEM) of borehole propagation. The linear delay differential equations are then incorporated into various closed loop steering configurations to further demonstrate the efficacy of the approach.
Antiobesity Effects of Etiocholanolones in Diabetes (<i>db</i>), Viable Yellow (<i>A<sup>vy</sup></i>), and Normal Mice* (1985)

Two metabolites of the adrenal steroid dehydroepiandrosterone (DHEA), 3 alpha-hydroxyetiocholanolone and 3 beta-hydroxyetiocholanolone, were found to have antiobesity properties with respect to both prevention of the development of obesity as well as weight reduction after obesity was established. All of the obesity types studied responded to metabolite therapy to a greater or lesser extent. The more natural obesity seen in certain strains of mice with aging responded most rapidly to the feeding of either metabolite. The effective dosage (0.1%) fed in the diet was only one quarter the dosage required for DHEA to produce the same effect in preventing diabetes symptoms in C57BL/Ks diabetic (db) mutant mice. Unlike DHEA, neither metabolite produced any undesirable estrogenic or androgenic side-effects. 3 alpha-hydroxyethiocholanolone and 3 beta-hydroxyetiocholanolone, formerly considered only as inert end products of steroid metabolism, have beneficial actions in mice with various diabetes-obesity conditions and may be metabolic effectors in their own right.
JSON Responses for the Registration Data Access Protocol (RDAP) (2015)

This document describes JSON data structures representing registration information maintained by Regional Internet Registries (RIRs) and Domain Name Registries (DNRs). These data structures are used to form Registration Data Access Protocol (RDAP) query responses.
Distributed autonomous wireless channel assignment algorithm with power control (1995)

Local autonomous dynamic channel allocation (LADCA) including power control is essential to accommodating the anticipated explosion of demand for wireless. The authors simulate call performance for users accessing channels in a regular cellular array with a base located at the center of each hexagon. The computer model includes stochastic channel demand and a propagation environment characterized by attenuation with distance as well as shadow fading. The study of LADCA shows that distributed power control and channel access can be combined in an access management policy that achieves satisfactory system capacity and provides desired call performance. The authors report: LADCA/power control is observed to be stable alleviating a major concern about users unaware of the signal to interference problems their presence on a channel might cause to others. There can be substantial inadvertent dropping of calls in progress caused by originating calls. Modeling user time dynamics is essential. LADCA contrasts very favorably with fixed channel allocation (FCA) in a comparative example.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lysis of a Broad Range of Epithelial Tumour Cells by Human <i>γ</i><i>δ</i> T Cells: Involvement of NKG2D ligands and T‐cell Receptor‐ versus NKG2D‐dependent Recognition (2007)

Human gammadelta T cells expressing a V gamma 9V delta 2 T-cell receptor (TCR) kill various tumour cells including autologous tumours. In addition to TCR-dependent recognition, activation of NKG2D-positive gammadelta T cells by tumour cell-expressed NKG2D ligands can also trigger cytotoxic effector function. In this study, we investigated the involvement of TCR versus NKG2D in tumour cell recognition as a prerequisite to identify tumour types suitable for gammadelta T-cell-based immunotherapy. We have characterized epithelial tumour cells of different origin with respect to cell surface expression of the known NKG2D ligands MHC class I-chain-related antigens (MIC) A/B and UL16-binding proteins (ULBP), and susceptibility to gammadelta T-cell killing. Most tumour cells expressed comparable levels of MICA and MICB as well as ULBP with the exception of ULBP-1 which was absent or only weakly expressed. Most epithelial tumours were susceptible to allogeneic gammadelta T-cell lysis and in the case of an established ovarian carcinoma to autologous gammadelta T-cell killing. Lysis of resistant cells was enhanced by pre-treatment of tumour cells with aminobisphosphonates or pre-activation of gammadelta T cells with phosphoantigens. A potential involvement of TCR and/or NKG2D was investigated by antibody blockade. These experiments revealed three patterns of inhibition, i.e. preferential inhibition by anti-TCR antibody, preferential inhibition by anti-NKG2D antibody, or additive blockade by anti-TCR plus anti-NKG2D antibodies. Our results indicate for the first time that the NKG2D pathway is involved in the lysis of different melanomas, pancreatic adenocarcinomas, squamous cell carcinomas of the head and neck, and lung carcinoma.
Adenosine 3',5'-monophosphate formation by preparations of rat liver soluble guanylate cyclase activated with nitric oxide, nitrosyI ferroheme, <i>S</i>-nitrosothiols, and other nitroso compounds (1980)

Cyclic AMP formation from ATP was stimulated by unpurified and partially purified soluble hepatic guanylate cyclase in the presence of nitric oxide (NO) or compounds containing a nitroso moiety such as nitroprusside, N-methyl-N-nitro-N-nitrosoguanidine (MNNG), nitrosyl ferroheme, and S-nitrosothiols. Cyclic AMP formation was undetectable in the absence of NO or nitroso compounds and was not stimulated by fluoride or glucagon, indicating the absence of adenylate cyclase activity. The nitroso compounds failed to activate, whereas fluoride or glucagon activated, adenylate cyclase in washed rat liver membrane fractions. Cyclic GMP formation from GTP was markedly stimulated by the soluble hepatic fraction in the presence of NO or nitroso compounds. Cyclic AMP formation by partially purified guanylate cyclase was competitively inhibited by GTP and cyclic GMP formation is well-known to be competitively inhibited by ATP. Therefore, it appears that activated guanylate cyclase, rather than adenylate cyclase, was responsible for the formation of cyclic AMP from ATP. Formation of cyclic AMP of cyclic GMP was enhanced by thiols, inhibited by hemoproteins and oxidants, and required the addition of either Mg2+ or Mn2+. Further, several nitrosyl ferroheme compounds and S-nitrosothiols stimulated the formation of both cyclic AMP and cyclic GMP by the soluble hepatic fraction. These observations support the view that soluble guanylate cyclase is capable, under certain well-defined conditions, of catalyzing the conversion of ATP to cyclic AMP.
A Potential Phosphate Crisis (1999)

Phosphate is a crucial component of DNA, RNA, ATP, and other biologically active compounds. Microbes, plants, and animals—including humans—cannot exist without it. Rocks containing phosphate have been discovered and are being mined at minimal cost. But resources are limited, and phosphate is being dissipated. Future generations ultimately will face problems in obtaining enough to exist.
Improvement of intelligent cyclic ADC resolution by randomization of DAC INL errors (2012)

The paper discusses a new method of improvement of conversion quality in intelligent cyclic analog-to-digital converters (ICADCs). One of the key factors influencing performance of ICADC is integral nonlinearity (INL) of its internal digital-to-analog converter (DAC). In the paper this influence is analyzed and there is proposed a method of its reduction using randomization of the errors caused by DAC INL and their averaging, which allows to improve ICADC resolution. Effectiveness of the developed method was examined in simulation experiments.
The Second Great Awakening as an Organizing Process, 1780-1830: An Hypothesis (1969)

eralizations which American historians use every now and again to describe a movement whose complexity eludes precision. The term usually includes monumental changes such as the break-up of Calvinism, an event which, like the thawing of northern rivers in the spring, heralded a new burst of creativity, energy and warmth. The Awakening is also understood as a conservative assertion of a new mode of religious authority by ministers who, fearful of losing their traditional role in New England society, tried to tame the rising democracy. It provided new channels not only for social control, but also for social service which some scholars have said was but a manifestation of the former. It burned in white-hot emotionalism in Kentucky, spreading along the frontier like a prairie fire, sweeping even beyond the backfires set by cautious seaboard ecclesiastics who had hoped to control it. It was an expansion of religious feeling unknown in American history. To be able to say so much about the Awakening might be taken as evidence that it is not such a vague term after all. Yet there are too many unsettling things about the literature relating to it to conclude that present interpretations are sufficiently comprehensive. The difficulties are a mixture of too much emphasis upon the truly intricate and challenging intellectual problems of the New England theology, and a certain awesome impressionability in regard to the non-rational phenomena of revivalism in the burned-over districts of New York and Vermont, and the campmeeting grounds of the South and West. In fact, it is emotionalism and devout piety, heart over reason, commitment as opposed to disinterestedness which characterizes the revival for many scholars. And it is its impact upon Congregationalist-Presbyterian dogmas of inability which invites the scrutiny of intellectual historians who quite rightly
Use of simulation to improve the kitting process at an EMS provider's facility (2003)

In an electronics manufacturing service (EMS) provider's environment, smooth and continuous manufacturing flow is extremely desirable. The kitting stage is of critical importance in a streamlined surface mount technology (SMT) assembly process. Based on historical data, the kitting process at the EMS provider where this research was conducted was identified as a focus for continuous improvement. This paper discusses the research undertaken to improve the kitting process at a medium volume, medium to high mix EMS provider's environment. The process improvement effort was based on a six-sigma approach with simulation being used as an analysis tool. At present, three of the five phases of the six-sigma approach have been completed with encouraging positive results. This paper discusses problems at the kitting stage of a printed circuit board (PCB) assembly process and the use of simulation to improve the process by reducing discrepancies.
Overlay measurement and analysis of x-ray/optical lithography for mix-and-match device applications (1994)

A joint Motorola/IBM experiment was performed in mix-and-match lithography across widely separated locations. A simple pattern placement metrology data set was created, and x-ray masks were manufactured according to this data. The same data was converted into a 5x reticle and optically stepped on wafers. The x-ray mask was designed to print upon two optical fields with one x-ray exposure. The x-ray mask was aligned to the wafers to produce box-in- box images for overlay metrology. The main overlay problems encountered were systematic offsets between x-ray and optical images, and average magnification error of approximately 8 ppm. The magnification error is substantial because of the 3 degree(s)C temperature difference between the optical stepper stage and the x-ray mask-writer. In an actual device run, the magnification differences will be removed by compensation in the e-beam writing of the x-ray mask. Offsets will be removed by use of a send-ahead wafer to determine the correct offset alignment in the x-ray stepper.
Related homing endonucleases I- <i>Bmo</i> I and I- <i>Tev</i> I use different strategies to cleave homologous recognition sites (2001)

A typical homing endonuclease initiates mobility of its group I intron by recognizing DNA both upstream and downstream of the intron insertion site of intronless alleles, preventing the endonuclease from binding and cleaving its own intron-containing allele. Here, we describe a GIY-YIG family homing endonuclease, I-BmoI, that possesses an unusual recognition sequence, encompassing 1 base pair upstream but 38 base pairs downstream of the intron insertion site. I-BmoI binds intron-containing and intronless substrates with equal affinity but can nevertheless discriminate between the two for cleavage. I-BmoI is encoded by a group I intron that interrupts the thymidylate synthase (TS) gene (thyA) of Bacillus mojavensis s87-18. This intron resembles one inserted 21 nucleotides further downstream in a homologous TS gene (td) of Escherichia coli phage T4. I-TevI, the T4 td intron-encoded GIY-YIG endonuclease, is very similar to I-BmoI, but each endonuclease gene is inserted within a different position of its respective intron. Remarkably, I-TevI and I-BmoI bind a homologous stretch of TS-encoding DNA and cleave their intronless substrates in very similar positions. Our results suggest that each endonuclease has independently evolved the ability to distinguish intron-containing from intronless alleles while maintaining the same conserved recognition sequence centered on DNA-encoding active site residues of TS.
Influence of Grain Growth on Dielectric Properties of Nb‐Doped BaTiO <sub>3</sub> (1971)

Effects of grain size and grain growth in Nb‐doped BaTiO 3 on temperature and frequency dependencies of the dielectric constant were investigated. When 0.65 μm powder is sintered to an average grain size of 1 μm, two dielectric constant peaks indicate the presence of Nb‐free BaTiO 3 and of Nb‐containing material. Single peaks are observed above room temperature after additional grain growth or when 0.07 μm powder is sintered to an average grain size of 1 μm. The Curie point of pure BaTiO 3 with 1 μm grains is 4 to 6°C lower than that of material with grains >10 μm. Thermodynamically, this behavior is accounted for by a phase inversion stress ∼ the room‐temperature stress.
Reverse Auctions and Universal Telecommunications Service: Lessons from Global Experience (2008)

The United States now spends around $7 billion on universal service programs-subsidies intended to ensure that the entire country has access to telecommunications services. Most of this money supports telecommunications service in "high cost" (primarily rural) areas, and the High Cost fund is growing quickly. In response to this growth, policymakers are considering using reverse auctions, or bids for the minimum subsidy, as a way to reduce expenditures. While the United States has not yet distributed funds for universal service programs using reverse auctions, the method has been used widely.\nFirst, reverse auctions are akin to standard government procurement procedures, which call for firms to bid on government contracts to keep prices down. Sending contracts out for bid is common in both simple and complex government contracting. Second, many countries around the world have used reverse auctions for distributing universal funds. This Article reviews global experiences with reverse auctions and discusses their implications for the United States. In particular, this Article reviews reverse auctions in Australia, Chile, Colombia, India, Nepal, and Peru. Not all of the auctions were successful, but they clearly demonstrate that reverse auctions can be an effective tool for revealing information about the true cost of providing universal coverage and for reducing expenditures on subsidies.
Genetic Relatedness of Type 1 and Type 2 Herpes Simplex Viruses (1972)

The extent of homology between herpes simplex virus(1) and(2) (HSV-1 and HSV-2) deoxyribonucleic acid (DNA) was measured in two ways: (i) by determination of the relative rate of hybridization of labeled HSV-1 and HSV-2 DNA to excess unlabeled HSV-1 or HSV-2 DNA immobilized on filters and (ii) by determination of the rate of hybridization of labeled HSV-1 and HSV-2 DNA to excess unlabeled HSV-1 or HSV-2 DNA in solution. Approximately 40% of HSV-1 and HSV-2 DNA is homologous at hybridization temperatures 25 C below the melting temperature (T(m)) of HSV DNA (liquid-filter annealing). Lowering the temperature to 34 C below the T(m) increased the extent of homology to 46% (liquid annealing). The extent of base-pairing in HSV-1-HSV-2 heteroduplex DNA was determined by thermal chromatography on hydroxyapatite. Heteroduplexes of HSV-1 and HSV-2 DNA eluted in a single peak whose midpoint (Te(50)) was 10 C below that of the homoduplex. Conspicuously absent were heteroduplexes that eluted at more than 15 C below the Te(50) of the homoduplex. The data indicate the existence of a variable region of DNA (54%) with very little, if any, homology and an invariable region (46%) with relatively good (85%) matching of base pairs.
Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice (2001)

The cyclooxygenase (COX)-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine Cox-2 gene in Min mice reduced the incidence of intestinal tumors, suggesting that it is required for tumorigenesis. However, it is not known if overexpression of Cox-2 is sufficient to induce tumorigenic transformation. We have derived transgenic mice that overexpress the human COX-2 gene in the mammary glands using the murine mammary tumor virus promoter. The human Cox-2 mRNA and protein are expressed in mammary glands of female transgenic mice and were strongly induced during pregnancy and lactation. Female virgin Cox-2 transgenic mice showed precocious lobuloalveolar differentiation and enhanced expression of the beta-casein gene, which was inhibited by the Cox inhibitor indomethacin. Mammary gland involution was delayed in Cox-2 transgenic mice with a decrease in apoptotic index of mammary epithelial cells. Multiparous but not virgin females exhibited a greatly exaggerated incidence of focal mammary gland hyperplasia, dysplasia, and transformation into metastatic tumors. Cox-2-induced tumor tissue expressed reduced levels of the proapoptotic proteins Bax and Bcl-x(L) and an increase in the anti-apoptotic protein Bcl-2, suggesting that decreased apoptosis of mammary epithelial cells contributes to tumorigenesis. These data indicate that enhanced Cox-2 expression is sufficient to induce mammary gland tumorigenesis. Therefore, inhibition of Cox-2 may represent a mechanism-based chemopreventive approach for carcinogenesis.
Laser-plasma debris from a rotating cryogenic–solid-Xe target (2010)

We investigate the characteristics of laser plasma debris that is responsible for damaging optics. The debris is composed of fast ions, neutral particles, and fragments, and originates from a solid Xe target on a rotating drum that we developed as an extreme ultraviolet (EUV) source. The ice fragments appear to be a problem most notably with solid Xe targets; however, we find that the damage induced by Xe ice fragments can be avoided by simply reducing the laser pulse energy. We find the number of fast neutral particles to be an order of magnitude less than the number of ions, and we clarify that the plasma debris is primarily composed of fast ions. In addition, we find that the number of fast ions having a few dozen keV of energy decreases when using the rotating target compared with the rest target. We attribute this to a gas curtain effect from the Xe gas localized at the rotating target surface. We estimate the sputtering rate of the Mo/Si mirror, which is caused primarily by the fast ions, to be 104 nm/1x10(6) shots at 190 mm from the source plasma and at an 11.25 degree angle from the incident laser beam. Up to the 1x10(6) shots exposure, remarkable degradation of the mirror reflectivity is not observed though the sputtering damages the mirror. Mitigation of the ions by using gas and/or magnetic fields will further improve the mirror lifetime. By comparing with a liquid jet Xe target, we conclude that the sputtering rate per conversion efficiency when using the solid Xe targets on the rotating drum is the same as that when using the liquid Xe targets. The high conversion efficiency of 0.9% in the rotating drum solid Xe target makes this technique useful for developing laser plasma EUV sources.
Preparation of Poly(styrene-<i>block</i>-butyl acrylate) Block Copolymer−Silicate Nanocomposites (2003)

An initiator was intercalated into the interlayer spacings of montmorillonite clay, from which poly(styrene-block-butyl acrylate) silicate nanocomposites were prepared using atom transfer radical polymerization. A mixture of exfoliated structure and intercalated structure was produced in the nanocomposite. The poly(butyl acrylate) chains form microdomains with an average size of 2−5 nm.