gebhart/patrepeval huggingface dataset:
Expression of the c-myc proto-oncogene in multiple myeloma and chronic lymphocytic leukemia: an in situ analysis (1991)

The c-myc gene plays a pivotal role in mediating the competence state for cell cycle transversion. This biologic role is in contradiction to reports of elevated expression of the gene in multiple myeloma, a tumor with restricted self-renewal capacity. To more clearly define the role of this gene in plasma cells of myeloma patients, c-myc messenger RNA (mRNA) and/or oncoprotein expression were semiquantitatively analyzed on the single cell level in 19 cases of multiple myeloma, among them 1 biclonal case and 1 case with coexistent chronic lymphocytic leukemia (CLL). Performing anti-sense/mRNA in situ hybridization, mature c-myc gene transcripts were detected in 92% (12 of 13) of cases and could definitely be attributed to the plasma cells by our study. The number of Ki 67-positive plasma cells actively passing the cell cycle was less than 1% and independent of c-myc gene expression. However, because the presence of the 152-c-MYC epitope was correlated to extent of marrow plasmacytosis (r = .64; P = .043) and content of plasmablasts (P = .09), the c-myc gene might serve a function different from proliferative activity, but also associated with tumor cell mass. In CLL cells (21 of 22 cases) and their benign counterparts, ie, bone marrow and peripheral blood lymphocytes, the anti-sense/c-myc mRNA hybridization signals remained below the threshold considered as cutpoint between negative and positive. The low amounts of c-myc transcripts were correlated to neither stage of disease (P = .52) nor lymphocyte counts (P = .24). Because the numbers of peripheral blood lymphoma cells were independent of tumor mass and of c-myc gene transcripts expressed, peripheral blood lymphocytosis might more likely reflect homing processes than proliferative activity in CLL.
The Ion-Exchange Membrane, Chlor-Alkali Process (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Ion-Exchange Membrane, Chlor-Alkali ProcessMaomi SekoCite this: Ind. Eng. Chem. Prod. Res. Dev. 1976, 15, 4, 286–292Publication Date (Print):December 1, 1976Publication History Published online1 May 2002Published inissue 1 December 1976https://pubs.acs.org/doi/10.1021/i360060a013https://doi.org/10.1021/i360060a013research-articleACS PublicationsRequest reuse permissionsArticle Views915Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Can we trust docking results? Evaluation of seven commonly used programs on PDBbind database (2010)

Docking is one of the most commonly used techniques in drug design. It is used for both identifying correct poses of a ligand in the binding site of a protein as well as for the estimation of the strength of protein-ligand interaction. Because millions of compounds must be screened, before a suitable target for biological testing can be identified, all calculations should be done in a reasonable time frame. Thus, all programs currently in use exploit empirically based algorithms, avoiding systematic search of the conformational space. Similarly, the scoring is done using simple equations, which makes it possible to speed up the entire process. Therefore, docking results have to be verified by subsequent in vitro studies. The purpose of our work was to evaluate seven popular docking programs (Surflex, LigandFit, Glide, GOLD, FlexX, eHiTS, and AutoDock) on the extensive dataset composed of 1300 protein-ligands complexes from PDBbind 2007 database, where experimentally measured binding affinity values were also available. We compared independently the ability of proper posing [according to Root mean square deviation (or Root mean square distance) of predicted conformations versus the corresponding native one] and scoring (by calculating the correlation between docking score and ligand binding strength). To our knowledge, it is the first large-scale docking evaluation that covers both aspects of docking programs, that is, predicting ligand conformation and calculating the strength of its binding. More than 1000 protein-ligand pairs cover a wide range of different protein families and inhibitor classes. Our results clearly showed that the ligand binding conformation could be identified in most cases by using the existing software, yet we still observed the lack of universal scoring function for all types of molecules and protein families.
The Relationship of Ovarian Steroids, Headache Activity and Menstrual Distress: A Pilot Study With Female Migraineurs (1992)

SYNOPSIS Fourteen female volunteers who met diagnostic criteria for migraine headache monitored their headache activity and menstrual distress symptoms for one menstrual cycle. Serum estradiol and progesterone levels, and menstrual distress measures were collected at four points of the menstrual cycle: menstrual, ovulatory, luteal and premenstrual. Results indicated that one patient (7.1%) had menstrual migraine, 10 patients (71.4%) had menstrually‐related headache and 3 (21.4%) had migraine headache unrelated to their menstrual cycle: subsequent analyses were conducted with the first two groups. Headache activity for the sample was highest during the premenstrual phase. Headache activity during the luteal and premenstrual phases was related to luteal phase progesterone levels. Menstrual distress was highest during the menstrual and premenstrual phases of the cycle, and these symptoms were related to higher estradiol levels, higher estradiol/progesterone ratios, and increased headache activity. These results indicated that for women with menstrual migraine or menstrually‐related migraine, luteal progesterone levels may be significantly associated with headache activity, and estradiol and the estradiol/progesterone ratio may be significantly related to menstrual distress during the pre‐menstrual phase of the cycle. The estradiol/progesterone ratio was not more related to headache or menstrual distress than either of these ovarian hormones alone. Suggestions for future research in this area are offered.
Investigational platelet-derived growth factor receptor kinase inhibitors in breast cancer therapy (2014)

An increased molecular understanding of response and resistance mechanisms to endocrine therapy will be essential for therapeutic advances in PDGFR-directed cancer therapy. Future developments in the field will rely on clinical studies where prospective analyses of target expression in breast cancer cells and in the tumor stroma are included. More selective PDGFR inhibitors with reduced side effects will be crucial for combinatorial therapies. Development of sensitive diagnostics is of critical importance for patient selection and monitoring of therapeutic effects.
Verfeinerung der Kristallstrukturen von Li<sub>2</sub>SiO<sub>3</sub> und Li<sub>2</sub>GeO<sub>3</sub> (1981)

Abstract The structures of Li 2 SiO 3 [ Cmc 21, a = 9.396(1), b = 5.396(1), c = 4.661(1) Å] and Li 2 GeO 3 [ Cmc 2 1 , a = 9.634(2), b = 5.481(2), c = 4.843(1) Å] have been refined to R values of 0.022 and 0.016 respectively. The distances within the tetrahedral chains were found to be: Si−O = 1.677(2), Ge−O = 1.811(3) Å for bridging oxygen and Si−O = 1.591(1), Ge−O = 1.711 (2) Å for non-bridging oxygen. The Li atoms are coordinated tetrahedrally.
Net die beste is goed genoeg : focus on Ayrshires (2009)

Die Ayrshire Telersgenootskap se raad het reeds hulle eerste vergadering van die jaar gehad, waar verskeie belangrike sake bespreek is. Een van die onderwerpe wat groot kommer by die raad wek, is die standaard van privaatbulle wat in kuddes gebruik word.
Patient-specific dosimetry using quantitative SPECT imaging and three-dimensional discrete Fourier transform convolution. (1997)

Our results showed that the 3D-DFT convolution method compared well with MCT calculations. The 3D-DFT approach is computationally much more efficient and, hence, the method of choice. This method is patient-specific and applicable to the dosimetry of soft-tissue tumors and normal organs. It can be implemented on personal computers.
Novel zero-voltage and zero-current-switching (ZVZCS) full bridge PWM converter using a simple auxiliary circuit (2002)

A novel zero voltage and zero current switching (ZVZCS) full bridge (FB) PWM power converter is presented to simplify the circuits of the previously presented ZVSCS power converters. A simple auxiliary circuit which consists of one small capacitor and two small diodes is added in the secondary to provide ZVZCS conditions to primary switches as well as to clamp secondary rectifier voltage. The additional clamp circuit for the secondary rectifier is not necessary. The auxiliary circuit includes neither lossy components nor additional active switches which makes the proposed power converter efficient and cost effective. The principle of operation, features and design considerations are illustrated and verified on a 2.5 kW, 100 kHz IGBT-based experimental circuit.
25 ns software correlator for photon and fluorescence correlation spectroscopy (2003)

A 25 ns time resolution, multi-tau software correlator developed in LABVIEW based on the use of a standard photon counting unit, a fast timer/counter board (6602-PCI National Instrument) and a personal computer (PC) (1.5 GHz Pentium 4) is presented and quantitatively discussed. The correlator works by processing the stream of incoming data in parallel according to two different algorithms: For large lag times (τ⩾100 μs), a classical time-mode (TM) scheme, based on the measure of the number of pulses per time interval, is used; differently, for τ⩽100 μs a photon-mode (PM) scheme is adopted and the time sequence of the arrival times of the photon pulses is measured. By combining the two methods, we developed a system capable of working out correlation functions on line, in full real time for the TM correlator and partially in batch processing for the PM correlator. For the latter one, the duty cycle depends on the count rate of the incoming pulses, being ∼100% for count rates ⩽3×104 Hz, ∼15% at 105 Hz, and ∼1% at 106 Hz. For limitations imposed by the fairly small first-in, first-out (FIFO) buffer available on the counter board, the maximum count rate permissible for a proper functioning of the PM correlator is limited to ∼105 Hz. However, this limit can be removed by using a board with a deeper FIFO. Similarly, the 25 ns time resolution is only limited by maximum clock frequency available on the 6602-PCI and can be easily improved by using a faster clock. When tested on dilute solutions of calibrated latex spheres, the overall performances of the correlator appear to be comparable with those of commercial hardware correlators, but with several nontrivial advantages related to its flexibility, low cost, and easy adaptability to future developments of PC and data acquisition technology.
Sökmotoroptimering på Google (2009)

Rapporten handlar om sökmotoroptimering för en ny webbplats. Rapporten täcker teorier och praktiska utförda experiment på webbplatsen. Syftet med rapporten var att vi skulle få mer kunskap kring sökmotoroptimering speciellt inriktad på Googles sökmotortjänst. Vi ville ta reda på hur man kan rankas så högt upp som möjligt på sökresultatssidan för specifika sökord. Då vi har läst webbprogrammering i nästan tre år utan att utbildningen gett oss några direkta kunskaper kring sökmotoroptimering föll detta som ett lämpligt val att fördjupa oss i. Metoder som täcks i denna rapport är indexering av en webbplats, rankning, PageRank, generell sökmotoroptimering och regionala skillnader på ett sökresultat hos Google. Teorier vi undersökte övergripande var om Googles sökmotor, Sandlåda Effekten, PageRank, Textlänkar, Meta taggar,Domännamn, Webbplatskartor och Webbdokumentet beträffande deras påverkan för sökmotoroptimering. Resultatet blev att webbplatsen vi sökmotoroptimerade rankades både bra och mindre bra på nyckelorden samt att webbplatsen blev generellt sökmotoroptimerad för sökmotorer. Resultatet från de praktiska experimenten blev delvis lyckade och slutsatsen blev att vi fått goda kunskaper om sökmotoroptimering av teoristudierna och det praktiska genomförandet.
The Immigrant (not simply Spanish) Purview and Poetics of George Santayana (2015)

The philosophy, criticism, and poetics of George Santayana (1863-1952) greatly influenced some of the most important writers in the Modernist moment - and are widely regarded as an oeuvre shaped to the core by Santayana’s experience and identity as a native Spaniard. While critics and biographers of Santayana have upheld the view that Santayana’s Spanishness is deeply evident in all reaches of his moral, theoretical, and aesthetic outlook, this essay argues not for the particular importance of Santayana’s Spanish roots, but rather for the importance of the cultural traumas of his immigrant experience in the US as they relate to his philosophical worldview and poetics. His cynical, materialist philosophies that decry faith in institutions as well as institutional faith, coupled with his privilege of ethical underpinnings and syntactic complexities in poetry, can be attributed more to his immigrant purview than to an especially Spanish persona. Recontextualising Santayana’s poetics in light of his biography, this essay reexamines Santayana’s key contributions to ideations of American Modernism, particularly in the field of poetry: Santayana’s influence on Wallace Stevens’s doubt and T. S. Eliot’s ‘objective correlative,’ some of the most lasting tropes of Modernist poetry - poetics derivative of a disillusionment endemic to the interstitial cultural sphere of the immigrant.
Synthetic mRNAs with Superior Translation and Stability Properties (2012)

The translational efficiency and stability of synthetic mRNA in both cultured cells and whole animals can be improved by incorporation of modified cap structures at the 5'-end. mRNAs are synthesized in vitro by a phage RNA polymerase transcribing a plasmid containing the mRNA sequence in the presence of all four NTPs plus a cap dinucleotide. Modifications in the cap dinucleotide at the 2'- or 3'-positions of m(7)Guo, or modifications in the polyphosphate chain, can improve both translational efficiency and stability of the mRNA, thereby increasing the amount and duration of protein expression. In the context of RNA-based immunotherapy, the latter is especially important for antigen production and presentation by dendritic cells. Protocols are presented for synthesis of modified mRNAs, their introduction into cells and whole animals, and measurement of their translational efficiency and stability.
Design of remote monitoring and fault diagnosis system for electric vehicle (2011)

Wireless remote monitoring and fault diagnosis system for electric vehicle, which gets vehicle data via CAN bus, transmits data to monitoring center by GPRS and Internet network. It implements the functions of real-time monitoring, fault diagnosis, alarm and so on.
Torsional deformation of the left ventricular midwall in human hearts with intramyocardial markers: regional heterogeneity and sensitivity to the inotropic effects of abrupt rate changes. (1988)

The spiral orientation of left ventricular (LV) fibers suggests that twisting about the ventricular long axis of the apex with respect to the base, i.e., torsional deformation, may be characteristic of LV contraction. To demonstrate this twisting motion, 10 orthotopic human cardiac allograft recipients were studied with biplane cineradiography of tantalum helices implanted within the LV midwall at 12 specific sites. Counterclockwise twisting about the LV long axis (as reviewed from apex to base) accompanied ventricular ejection in all patients. Torsional deformation angles, measured relative to a reference minor axis at the base, were substantially smaller in the anteroapical wall, as compared with counterparts in the apical third of the inferior and lateral walls (anterior = 13.3 +/- 6.0 degrees, inferior = 18.7 +/- 6.3 degrees, and lateral = 23.4 +/- 10.7 degrees). Torsional angles at the midventricular level were roughly half as much and exhibited similar regional variabilities (anterior = 7.6 +/- 3.3 degrees, inferior = 9.0 +/- 3.3 degrees, lateral = 10.7 +/- 5.2 degrees, and septal = 8.8 +/- 3.8 degrees). Comparison of control beats and the initial beat after abrupt cessation of rapid atrial pacing (126 +/- 10 beats/min) with return to the control heart rate (96 +/- 9 beats/min) permitted the mild positive inotropic effect of tachycardia to be assessed at similar levels of ventricular load. Torsional deformation of the anteroapical and inferoapical sites increased significantly (p less than 0.05) over control values to 15.6 +/- 7.5 degrees and 21.2 +/- 5.5 degrees, respectively. In contrast, torsional deformation of the lateral wall was essentially unchanged. These data provide direct evidence for torsional deformation of the left ventricle in humans, demonstrate that torsion of the LV chamber is nonuniform, and suggest a dependence of LV torsion upon contractile strength that is attenuated in the lateral wall.
Annular Arrays for Quantitative Pulsed Doppler Ultrasonic Flowmeters (1983)

A theory, based on the Fourier-Bessel series expansion, is developed to synthesize circularly symmetric field patterns by means of concentric annular arrays. The application of this theory to the formation of variable-width uniform sector beams is studied in detail and results in a canonical design procedure. Calculated beam patterns are compared to the actual measured patterns obtained from a prototype array suitable for transcutaneous investigation of the central blood-flow system and are observed to be in good agreement. The implementation of such arrays in the compensated-first-moment flowmeter is described. Methods of beam-pattern improvement are also discussed.
Aptamer-modified magnetic nanoprobe for molecular MR imaging of VEGFR2 on angiogenic vasculature (2013)

Nucleic acid-based aptamers have been developed for the specific delivery of diagnostic nanoprobes. Here, we introduce a new class of smart imaging nanoprobe, which is based on hybridization of a magnetic nanocrystal with a specific aptamer for specific detection of the angiogenic vasculature of glioblastoma via magnetic resonance (MR) imaging. The magnetic nanocrystal imaging core was synthesized using the thermal decomposition method and enveloped by carboxyl polysorbate 80 for water solubilization and conjugation of the targeting moiety. Subsequently, the surface of the carboxylated magnetic nanocrystal was modified with amine-functionalized aptamers that specifically bind to the vascular growth factor receptor 2 (VEGFR2) that is overexpressed on angiogenic vessels. To assess the targeted imaging potential of the aptamer-conjugated magnetic nanocrystal for VEGFR2 markers, the magnetic properties and MR imaging sensitivity were investigated using the orthotopic glioblastoma mouse model. In in vivo tests, the aptamer-conjugated magnetic nanocrystal effectively targeted VEGFR2 and demonstrated excellent MR imaging sensitivity with no cytotoxicity.
Practical vignetting correction method for digital camera with measurement of surface luminance distribution (2016)

Vignetting refers to the fall-off pixel intensity from the centre towards the edges of the image. This effect is undesirable in image processing and analysis. In the literature, the most commonly used methods of vignetting correction assume radial characteristic of vignetting. In the case of camera lens systems with non-radial vignetting, such approach leads to insufficient correction. Additionally, the majority of vignetting correction methods need a reference image acquired from a uniformly illuminated scene, what can be difficult to achieve. In this paper, we propose a new method of vignetting correction based on the local parabolic model of non-radial vignetting and compensation of non-uniformity of scene luminance. The new method was tested on camera lens system with non-radial vignetting and non-uniformly illuminated scene. In these conditions, the proposed method gave the best correction results among the tested methods.
Survey on Skeleton Gesture RecognitionProvided by Kinect (2014)

This survey paper proposes a real time implementation for a human skeleton recognition by Kinect that can be used for vision-based human interfaces.Using of the low cost device Kinect with its SDK tool kit gives us a possibility to resolve with ease some difficult problems encounteredwhen working with conventional cameras. In particular, we are interested in a specific stream of vector extraction of twenty body-joint as a coordinate to identify skeletal structure of the human body captured by Kinect camera. The recognized gesture patterns from skeletal structure used to study various postures like stand, sit down, and lie down.In conventional systems they are bypassing so many problems when they are working in ideal conditions. The velocities and angle between the joints hitting the floor by tracking the 3D joints are discussed. In this paper different methodologies, segmentation, feature extraction, classifiers are conferred and compared.
Optimal Tool Selection Based on Genetic Algorithm in a Geometric Cutting Simulation. (1994)

a new method of optimal selection of cutting tools in a geometric cutting simulation . Firstly an area to be cut by an end-milling tool is calculated according to each different tool . The shape of the workpiece *
The development of a folded 3D flexible package module based on flexible substrate (2012)

Increasingly aggressive requirements of active devices have challenged the physical limits of conventional packaging technologies. Bandwidth-intensive consumer and enterprise applications have precipitated an insatiable demand for ever-increasing density, functionality, and portability requirements of active devices. Such aggressive requirements, which have challenged the viability of conventional packaging technologies, have prompted researchers and engineers to contemplate suitable alternatives to placate such escalating demands. An innovative solution that is stimulating increasing interest is 3D flexible substrate packaging technology in part because of its high degree of scalability in a compact form-factor. However, this particular packaging topology has yet to mature into a mainstream solution in the industrial environment due to its prohibitive implementation costs. This paper proposes a practical, streamlined methodology of designing, fabricating and testing folded 3D flexible package modules that address both manufacturing costs and time-to-market sensitivities. Detailed in this paper is a pedagogical example of the proposed methodology that depicts the design optimization, fabrication, and characterization of daisy-chained chips incorporated into a 3D flexible package topology on flexible substrates. Electrical and pertinent reliability test results demonstrate the viability of the proposed methodology for folded 3D flexible package technology.