gebhart/patrepeval huggingface dataset:
Trigger point evaluation in migraine patients: an indication of peripheral sensitization linked to migraine predisposition? (2006)

Although migraine is a neurovascular disorder, both scalp tenderness and referred pain have been observed in migraine patients. The present study was carried out to investigate the presence of trigger points eliciting referred pain in 98 migraine patients and in 32 healthy subjects. Trigger points were found in 92 (93.9%) migraineurs and in nine (29%) controls (P < 0.0001). The number of individual migraine trigger points varied from zero to 14 (modal number: 4), and was found to be related to both the frequency of migraine attacks (P < 0.0001), and the duration of the disease (P = 0.017). About 74% of the total detected trigger points were found in temporal and/or suboccipital areas; other locations were mainly found in patients showing more than four trigger points. Trigger point palpation provoked a migraine attack in 30 (30.6%) patients. Pericraneal allodynia was found in 15 (15.3%) patients. These data indicate that nociceptive peripheral sensitization is a usual finding in migraine, and that central sensitization can develop in patients with frequent attacks and long-lasting disease. Trigger points' detection in migraine patients could be useful when applying therapies like acupuncture, needling or botulinum toxin injections directed to reduce peripheral sensitization.
Cyclic Prefix Adaptation with Constant Overall Symbol Time for DFT-Spread-OFDM and OFDM (2016)

For DFT-spread-OFDM or OFDM, if the delay spread varies in a wide range and the symbol duration is relatively short, adapting the cyclic prefix (CP) duration rather than using a fixed one may significantly improve the spectral efficiency while preventing inter-symbol interference (ISI). In practice, it may be beneficial to have a constant overall DFT-spread-OFDM/OFDM symbol time, which is the sum of the duration of a CP and the duration of a data portion. We propose to adapt the CP duration to the delay spread without changing the overall symbol time for DFT-spread-OFDM or OFDM, and address implementation challenges. In particular, we propose changing the clocking rate of ADC and DAC or using a Farrow filter to reduce the computational complexity of arbitrary-size DFT/IDFT resulting from the adaptation.
Analytical models for the frequency response of multi-layer graphene nanoribbon interconnects (2012)

Analytical models for frequency response of multilayer graphene interconnects are obtained by a general multi-conductor analysis approach. The dependence of frequency response on the number of layers is studied for two types of contacts: top and side contacts. Although virtually all experiments on multi-layer graphene use top contacts that couple only to the top layer, the analytical models available consider side contacts that couple to all the layers. It is shown that for side contacts, the frequency response improves continuously with number of layers, unlike the top contacts, which show very little improvement beyond a few layers. The delay and energy-delay-product obtained from the frequency response are minimized at some optimal number of layers, which is dependent on the interconnect length.
438. Dimethylaminochlorosilanes (1952)

R. Cass and G. E. Coates, J. Chem. Soc., 1952, 2347 DOI: 10.1039/JR9520002347
Access to cancer medicines in Europe: an analysis of existing challenges and countries’ responses (2016)

Access to new cancer medicines, particularly their coverage and affordability, is a matter of great concern to payers, patients and the pharmaceutical industry. Yet, little comparative evidence on actual use and its determinants is available. This thesis aimed to analyse the extent to which access to cancer medicines varies across a sample of European countries, what determines these differences, whether they matter, and what are countries doing to improve access. These objectives were achieved through the use of quantitative and qualitative methods including multilevel mixed effects models, survival analysis and the complementary log-log transformation of the Cox proportional hazard model, literature reviews and interviews to inform the development of conceptual frameworks, and a comparative longitudinal analysis of the implementation of MEAs. Results show that there are wide cross-country differences in access to cancer medicines in Belgium, Estonia, Scotland, and Sweden. These differences were determined by time to entry of new medicines, medical need (i.e. incidence of the disease) and factors affecting treatment decisions (e.g. coverage, prices, and financing mechanisms). The added clinical value of medicines explained the shorter time to launch in Estonia and higher consumption in Scotland but not in the other countries. This emphasises the importance of health technology assessment processes in identifying and making cost-effective medicines available and limiting the utilisation of non-cost-effective ones. The latter is particularly important given the opportunity cost of funding new cancer medicines. Managed entry agreements have increasingly been implemented to address issues of uncertainty and high prices when making coverage decisions. Through their action on price, effectiveness and use, they are able to influence cost-effectiveness and budget impact, two key variables guiding reimbursement decisions. Some of the most important contributions from this thesis include: (1) the development of a blueprint to analyse access to cancer medicines in Europe quantitatively and qualitatively; (2) the identification of likely determinants of differences in access to cancer medicines which can guide policy-makers efforts in managing access to new therapies; and (3) the development of a conceptual framework for managed entry agreements which can support their design and evaluation.
First Prize: A Novel Device to Prevent Stone Fragment Migration During Percutaneous Lithotripsy (2014)

Use of the PercSac in conjunction with stone fragmentation has the potential to reduce the occurrence of residual fragments after PCNL or cystolitholapaxy. Further in vitro testing in a kidney model is planned.
Cellulose Reactivity in Supercritical Methanol in the Presence of Solid Acid Catalysts: Direct Synthesis of Methyl-levulinate (2010)

Supercritical MeOH and MeOH−H2O (90/10) mixtures were used as reaction media for one-pot dissolution−conversion of microcrystalline cellulose. In the absence of catalyst, the cellulose dissolution was almost complete under supercritical conditions (300 °C/10 MPa/1 min) but relative low amounts of value-added chemicals were obtained. Addition of solid acid catalysts such as CsxH3−xPW12O40 or sulfated zirconia led in the same conditions to formation of valuable methyl-levulinate in remarkable yields close to 20%.
Premium Rates in the German Motor Insurance Business (1963)

In his report to the XVIth International Congress of Actuaries in Brussels [5] in 1960 the author has given a survey of the German Motor Insurance Business and in this it was mentioned that a change might be expected from the flat-tariff prescribed by law into individual tariffs for every insurance company. The Federal Ministry of Economics decided this question at the end of 1959 by signing the price regulation PR 15/59 [I] The federal price-fixing treaty had thus come to an end after several decades. Three steps are planned for the transitional period: For the years i960 and 1961 the flat-tariff remained in existence; free competition was introduced by providing for a return of premiums from technical surplus. At the beginning of 1962 the second phase of liberalisation began: Between 1962–1965 each insurance company has to compute its own tariff which has to be approved by the Federal Ministry of Economics. No deviations are permitted from the approved tariffs. Nobody can tell yet what the third phase in 1966 will bring. At the time the price-fixing agreements were cancelled it was unanimously agreed that proper competition should be maintained and that ruinous price competition which would harm the interests of victims of traffic accidents must be avoided [4]. Trusts or tariff rings were not taken into consideration. However, some market regulations were set up by co-operation between the different parties. The benefits (insurance conditions) are the same for all insurance enterprises. Also there are only few alternatives in the tariff conditions.
Mutual Authentication Scheme for EPC Tags-Readers in the Supply Chain (2009)

We present a privacy-preserving mutual authentication scheme for RFID. The scheme is compatible with supply chains originating at multiple manufactures, and is based on decentralized local databases connected to RFID readers. RFID tag capabilities are compliant with EPG Class 1 Generation 2: tags perform only random number generation, crypto CRC and XOR operations and do not store any global secrets. The scheme with some proposed extensions provides protection against fake tags, fake readers, replay, man-in-the-middle, compromise of reader or tag, cloning, and desynchronization attacks.
Applications of yokeless flux confinement (1988)

A recently developed generalized technique for the production of large confined magnetic fields is used to design a number of novel permanent-magnet flux sources. The simplest of these produces a transverse field in a long cavity of a rectangular cross section. In such structures, uniform fields that are of the order of the remanence of the material used are obtained easily. Applications include: NMR imaging, general electron device biasing, and the provision of bases for various periodic magnetic structures, such as wigglers, undulators, and twisters. Slight elaboration of such configurations can produce fields of up to three times the remanence. The fields of such structures can be readily adjusted by mechanical means, with continuous variation from zero to the maximum field. The wigglers and twisters afford instantaneous conversion from wiggler to twister and conversely. Adaptations of the basic principles can be used to produce radial, conical, and other unusual field orientations.
Dry and Noncontact EEG Sensors for Mobile Brain–Computer Interfaces (2011)

Dry and noncontact electroencephalographic (EEG) electrodes, which do not require gel or even direct scalp coupling, have been considered as an enabler of practical, real-world, brain-computer interface (BCI) platforms. This study compares wet electrodes to dry and through hair, noncontact electrodes within a steady state visual evoked potential (SSVEP) BCI paradigm. The construction of a dry contact electrode, featuring fingered contact posts and active buffering circuitry is presented. Additionally, the development of a new, noncontact, capacitive electrode that utilizes a custom integrated, high-impedance analog front-end is introduced. Offline tests on 10 subjects characterize the signal quality from the different electrodes and demonstrate that acquisition of small amplitude, SSVEP signals is possible, even through hair using the new integrated noncontact sensor. Online BCI experiments demonstrate that the information transfer rate (ITR) with the dry electrodes is comparable to that of wet electrodes, completely without the need for gel or other conductive media. In addition, data from the noncontact electrode, operating on the top of hair, show a maximum ITR in excess of 19 bits/min at 100% accuracy (versus 29.2 bits/min for wet electrodes and 34.4 bits/min for dry electrodes), a level that has never been demonstrated before. The results of these experiments show that both dry and noncontact electrodes, with further development, may become a viable tool for both future mobile BCI and general EEG applications.
Long-term correlation tracking (2015)

In this paper, we address the problem of long-term visual tracking where the target objects undergo significant appearance variation due to deformation, abrupt motion, heavy occlusion and out-of-view. In this setting, we decompose the task of tracking into translation and scale estimation of objects. We show that the correlation between temporal context considerably improves the accuracy and reliability for translation estimation, and it is effective to learn discriminative correlation filters from the most confident frames to estimate the scale change. In addition, we train an online random fern classifier to re-detect objects in case of tracking failure. Extensive experimental results on large-scale benchmark datasets show that the proposed algorithm performs favorably against state-of-the-art methods in terms of efficiency, accuracy, and robustness.
Comparison Studies of Whole Blood Stored in ACD and CPD and with Adenine (1968)

Using 70% 24‐hour posttransfusion survival as one of the criteria of preservation, ACD and CPD anticoagulant solutions with and without adenine were tested after storage for 28, 35, or 42 days. At 28 days, all solutions had average survivals of 70% or better. The average survival values for the ACD and CPD solution groups were less than 70% at 35 and 42 days. However, both solutions with adenine had a group average value over 70% even after 35 or 42 days of storage. The average survival values between the two anticoagulants alone, were not significantly different at each time period. The two anticoagulants when adenine was included had increased survival and there was no statistical difference between the levels. In comparing two units obtained from the same subject, survival percentages were significantly higher in almost every recipient when the adenine‐supplemented stored blood was used. Other chemical determinations did not show significant alterations and no toxic effects were observed in the recipients. Since all units containing adenine had survival values greater than 70% in the 28‐ and 35‐day periods, these units would appear to have been effectively preserved and blood stored under these conditions could be used in routine transfusions, reserving units stored 42 days for emergency use.
Changes in Patient and Technique Survival over Time among Incident Peritoneal Dialysis Patients in Canada (2012)

Survival on PD continues to improve with only modest changes in PD technique failure. Peritonitis remains an ongoing and modifiable source of PD technique failure.
Kinetics and chemiluminescence of ozone-aromatic reactions in the gas phase (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics and chemiluminescence of ozone-aromatic reactions in the gas phaseS. Toby, L. J. Van de Burgt, and F. S. TobyCite this: J. Phys. Chem. 1985, 89, 10, 1982–1986Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 May 1985https://pubs.acs.org/doi/10.1021/j100256a034https://doi.org/10.1021/j100256a034research-articleACS PublicationsRequest reuse permissionsArticle Views253Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Treatment of Endometriosis (2001)

Endometriosis is the growth of endometrium outside the uterine cavity or myometrium (endometriotic implants), usually in the peritoneal cavity (Figure 1). The question of how the tissue attains this abnormal placement is controversial, although the predominant theory is that retrograde menstruation is the cause.1 Additional factors that may be important in pathogenesis include immunologic abnormalities, endometrial disorders, and peritoneal dysfunction.1 The principal manifestations of endometriosis are pelvic pain and infertility.2 The extent of the pain is influenced primarily by the location and depth of the endometriotic implant, with deep implants in highly innervated areas most consistently associated with pain. Infertility . . .
An Ultra-low Power RNN Classifier for Always-On Voice Wake-Up Detection Robust to Real-World Scenarios (2021)

We present in this paper an ultra-low power (ULP) Recurrent Neural Network (RNN) based classifier for an always-on voice Wake-Up Sensor (WUS) with performances suitable for real-world applications. The purpose of our sensor is to bring down by at least a factor 100 the power consumption in background noise of always-on speech processing algorithms such as Automatic Speech Recognition, Keyword Spotting, Speaker Verification, etc. Unlike the other published approaches, we designed our wake-up sensor to be robust to unseen real-world noises for realistic levels of speech and noise by carefully designing the dataset and the loss function. We also specifically trained it to mark only the speech start rather than adopting a traditional Voice Activity Detection (VAD) approach. We achieve less than 3% No Trigger Rate (NTR) for a duty cycle less than 1% in challenging background noises pooled using a model of an analogue front-end. We demonstrate the superiority of RNNs on this task compared to the other tested approaches, with an estimated power consumption of 45 nW for the RNN itself in 65nm CMOS and a minimal memory footprint of 0.52 kB.
Significance of Capacitative Ca<sup>2+</sup>Entry in the Regulation of Phosphatidylserine Expression at the Surface of Stimulated Cells (1999)

The transverse redistribution of plasma membrane phosphatidylserine is one of the hallmarks of cells undergoing apoptosis and also occurs in cells fulfilling a more specialized function, such as platelets after appropriate activation. Although an increase in intracellular Ca2+ is required to trigger the remodeling of the plasma membrane, little information regarding intracellular signals leading to phosphatidylserine externalization has been provided. Scott syndrome is an extremely rare inherited disorder of the migration of phosphatidylserine toward the exoplasmic leaflet of the plasma membrane of stimulated blood cells. We have studied here the intracellular Ca2+ mobilization and Ca2+ entry involved in tyrosine phosphorylation in Epstein Barr virus (EBV)-infected B cells derived from a patient with Scott syndrome, her daughter, and control subjects. An alteration of Ca2+ entry through the plasma membrane and subsequent tyrosine phosphorylation induced by Ca2+ were observed in Scott EBV-B cells, but the release of Ca2+ from intracellular stores was normal. Furthermore, phosphatidylserine externalization at the surface of stimulated cells does not depend on tyrosine kinases. These results suggest that the defect of phosphatidylserine exposure in Scott syndrome cells is related to the alteration of a particular way of Ca2+ entry, referred to as capacitative Ca2+ entry, although some differences may be related to the cell type. Hence, this genetic mutant testifies to the prime significance of Ca2+ signaling in the regulation of phosphatidylserine expression at the surface of stimulated cells.
A META-ANALYSIS OF QTL ASSOCIATED WITH EAR ROT RESISTANCE IN MAIZE (2010)

The three predominant ear rot (ER) diseases of maize are Aspergillus ear rot (AER), Fusarium ear rot (FER) and Gibberella ear rot (GER). These three diseases are responsible for most disease-related reductions in yield and quality. To identify QTL chromosome regions for resistance to these three ERs and to investigate the re- lationship among these resistances, 87(eightyseven) initial QTL from 14 studies were used to project meta-QTL (MQTL) on a high-density genetic linkage map (IBM2 neighbors 2008). The results showed that 29 MQTL (each MQTL comprising two to six initial QTL) were projected on chromosomes 1 to 8. Six MQTL located on chromo- somes 3 and 4 were recommended to use for improving ER resistance in a marker assisted selection (MAS) pro- gram. Meta-analysis also indicated that QTL from different ER types and resistance sources were clustered on the same chromosome regions, particularly on bins 3.04 and 2.08. Among eight resistance sources, CO387 contributed 18 of 29 MQTL.
A 90 - 100-GHz 4 x 4 SiGe BiCMOS Polarimetric Transmit/Receive Phased Array With Simultaneous Receive-Beams Capabilities (2013)

This paper presents a 4 × 4 transmit/receive (T/R) SiGe BiCMOS phased-array chip at 90-100 GHz with vertical and horizontal polarization capabilities, 3-bit gain control (9 dB), and 4-bit phase control. The 4 × 4 phased array fits into a 1.6×1.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> grid, which is required at 94 GHz for wide scan-angle designs. The chip has simultaneous receive (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> ) beam capabilities (V and H) and this is accomplished using dual-nested 16:1 Wilkinson combiners/divider with high isolation. The phase shifter is based on a vector modulator with optimized design between circuit level and electromagnetic simulation and results in 1 dB and gain and phase error, respectively, at 85-110 GHz. The behavior of the vector modulator phase distortion versus input power level is investigated and measured, and design guidelines are given for proper operation in a transmit (Tx) chain. The V and H Rx paths result in a gain of 22 and 25 dB, respectively, a noise figure of 9-9.5 (max. gain), and 11 dB (min. gain) measured without the T/R switch, and an input P1 dB of -31 to -26 dBm over the gain control range. The measured output P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sat</sub> is ~ -5 dBm per channel, limited by the T/R switch loss. Measurements show ±0.6- and ±0.75-dB variation between the 4 × 4 array elements in the Tx mode (P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sat</sub> ) and Rx mode, respectively, and 40-dB coupling between the different channels on the chip. The chip consumes 1100 mA from a 2-V supply in both the Tx and Rx modes. The design can be scaled to >10 000 elements using polyimide redistribution layers on top of the chip and the application areas are in W-band radars for landing systems.
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis (2004)

Tissue factor (TF) is the primary cellular initiator of blood coagulation and a modulator of angiogenesis and metastasis in cancer. Indeed, systemic hypercoagulability in patients with cancer and TF overexpression by cancer cells are both closely associated with tumor progression, but their causes have been elusive. We now report that in human colorectal cancer cells, TF expression is under control of 2 major transforming events driving disease progression (activation of K-ras oncogene and inactivation of the p53 tumor suppressor), in a manner dependent on MEK/mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3'-kinase (PI3K). Furthermore, the levels of cell-associated as well as circulating (microvesicle-associated) TF activity are linked to the genetic status of cancer cells. Finally, RNA interference experiments suggest that TF expression is an important effector of the K-ras-dependent tumorigenic and angiogenic phenotype in vivo. Thus, this study establishes a causal link between cancer coagulopathy, angiogenesis, and genetic tumor progression.