gebhart/patrepeval huggingface dataset:
Integrating syllable boundary information into speech recognition (2002)

We examine the proposition that knowledge of the timing of syllabic onsets may be useful in improving the performance of speech recognition systems. A method of estimating the location of syllable onsets derived from the analysis of energy trajectories in critical band channels has been developed, and a syllable-based decoder has been designed and implemented that incorporates this onset information into the speech recognition process. For a small, continuous speech recognition task the addition of artificial syllabic onset information (derived from advance knowledge of the word transcriptions) lowers the word error rate by 38%. Incorporating acoustically-derived syllabic onset information reduces the word error rate by 10% on the same task. The latter experiment has highlighted representational issues on coordinating acoustic and lexical syllabifications, a topic we are beginning to explore.
THE EFFECT OF TEMPERATURE ON THE OIL CONTENT AND FATTY ACID COMPOSITION OF THE OILS FROM SEVERAL OIL SEED CROPS (1965)

Plants of rape, safflower, sunflower, flax, and castor bean were grown at temperatures of 10, 16, 21, and 26.5 °C for the period of seed development. Oil content of sunflower, safflower, and castor bean was not affected by temperature. Highest oil content in rape and flax was found at the lowest temperature and a continual decrease was observed with increases in temperature. Fatty acid composition of the oil from safflower and castor bean was not affected by a change in temperature. In the other three species the amount of the more highly unsaturated fatty acids decreased as the temperature was increased. This decrease was accompanied by an increase in oleic acid. The levels of saturated fatty acids in all of the species were not affected by changes in temperature.
Repeated deletion channels (2014)

We consider the question of the capacity of the deletion channel when multiple copies of the codeword are sent independently through the channel. This type of coding problem is straightforward for standard erasure and error channels, but is more challenging in the deletion channel setting. Our results show that when the same codeword is sent k times through the channel, each time with independent deletions with probability d, the optimal communication rate under a random codebook is 1 - αH(d <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</sup> ) + O(d <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</sup> ) for an explicitly given constant α.
Escherichia coli transcript cleavage factors GreA and GreB stimulate promoter escape and gene expression in vivo and in vitro. (1995)

The process of RNA chain initiation by RNA polymerases plays a central role in the regulation of transcription. In this complex phase of transcription, short oligomers are synthesized and released from the enzyme-promoter complex in a reaction termed abortive initiation. The polymerase undergoes many cycles of abortive initiation prior to completion of the initiation process, which is signaled by the translocation of the enzyme away from the promoter, release of sigma factor, and formation of an elongation complex in which the RNA is stably bound. We have studied the parameters that affect escape from the promoter by Escherichia coli RNA polymerase for the phage T7 A1 promoter, the phage T5 N25 promoter, and the chimeric promoter T5 N25antiDSR. The latter site contains a synthetic initial transcribed region that reduces its ability to synthesize RNA both in vivo and in vitro. Clearance from T5 N25antiDSR can be stimulated up to 10-fold in vitro by addition of the E. coli transcript cleavage factor GreA or GreB, but these factors have little effect on transcription from the normal T7 A1 or T5 N25 promoters. Using an E. coli strain lacking GreA and GreB, we were also able to show stimulation of transcription by the Gre factors from the T5 N25antiDSR promotor in vivo. The stimulation of RNA chain initiation by Gre factors, together with their known biochemical properties in the transcription elongation reaction, suggests some specific models for steps in the transcription initiation reaction.
Techniques For Automatic Music Transcription. (2000)

[TODO] Add abstract here.
Selective Serotonin Reuptake Inhibitor Drug Interactions in Patients Receiving Statins (2014)

Elderly patients commonly receive statin drugs for the primary or secondary prevention of cardiovascular and cerebrovascular events. Elderly patients also commonly receive antidepressant drugs, usually selective serotonin reuptake inhibitors (SSRIs), for the treatment of depression, anxiety, or other conditions. SSRIs are associated with many pharmacokinetic drug interactions related to the inhibition of the cytochrome P450 (CYP) metabolic pathways. There is concern that drugs that inhibit statin metabolism can trigger statin adverse effects, especially myopathy (which can be potentially serious, if rhabdomyolysis occurs). However, a detailed literature review of statin metabolism and of SSRI effects on CYP enzymes suggests that escitalopram, citalopram, and paroxetine are almost certain to be safe with all statins, and rosuvastatin, pitavastatin, and pravastatin are almost certain to be safe with all SSRIs. Even though other SSRI-statin combinations may theoretically be associated with risks, the magnitude of the pharmacokinetic interaction is likely to be below the threshold for clinical significance. Risk, if at all, lies in combining fluvoxamine with atorvastatin, simvastatin, or lovastatin, and even this risk can be minimized by using lower statin doses and monitoring the patient.
Rat brain natriuretic peptide. Isolation from rat heart and tissue distribution. (1990)

We have isolated a cardiac natriuretic peptide of 5,000 d from atrial tissues from 500 rats and determined its amino acid sequence. The 5,000 d atrial natriuretic factor was elucidated to be a 45 amino acid peptide with the sequence of S-Q-D-S-A-F-R-I-Q-E-R-L-R-N-S-K-M- A-H-S-S-S-C-F-G-Q-K-I-D-R-I-G-A-V-S-R-L-G-C-D-G-L-R-L-F by sequencing the native peptide and its lysyl endopeptidase digests. The sequence of this peptide was identical to the amino acid sequence (51-95) of the rat brain natriuretic peptide precursor deduced from the complementary DNA (cDNA) sequence. The cardiac natriuretic peptide with a molecular weight of 5,000, or rat brain natriuretic peptide, was identified as the major storage form and as the sole secretory form derived from the brain natriuretic peptide precursor in the rat heart. The rat brain natriuretic peptide level in the atrium was 3.68 +/- 0.61 micrograms/g, which represents about 4% of that of atrial natriuretic factor. Rat brain natriuretic peptide was also detected in the ventricle. The ratio of brain natriuretic peptide to atrial natriuretic peptide in the ventricle was approximately 30% and much higher than that in the atrium. Rat brain natriuretic peptide, however, was not detectable in the brain. We conclude that the 5,000 d cardiac natriuretic peptide is rat brain natriuretic peptide with 45 amino acids derived from the brain natriuretic peptide precursor and is secreted from the rat heart as a novel cardiac hormone.
Isolation, Complementation, and Initial Characterization of Temperature-Sensitive Mutants of the Baculovirus <i>Autographa californica</i> Nuclear Polyhedrosis Virus (1979)

Sixteen temperature-sensitive mutants of Autographa californica nuclear polyhedrosis virus were isolated. Several interesting phenotypes were observed. A large proportion of the mutants were unable to form polyhedral occlusion bodies (polyhedra) at the nonpermissive temperature (32.5 degrees C). At 32.5 degrees C, one mutant formed plaques in which the cells lacked polyhedra. Another mutant type was defective in the production of progeny extracellular nonoccluded virus and produced a "plaque" consisting of only a single cell containing polyhedra at 32.5 degrees C. One mutant was defective in plaque formation, progeny nonoccluded virus formation, and polyhedra formation at 32.5 degrees C. Several mutants produced nonoccluded virus but failed to produce plaques or polyhedra at 32.5 degrees C. Other phenotypes were also distinguished. Complementation analyses, performed by either measuring the increase in extracellular nonoccluded virus formation or by observing polyhedra formation in mixed infections at 32.5 degrees C, indicated the presence of 15 complementation groups. A high frequency of recombination was observed. Four of the mutants were found to be host dependent in their temperature sensitivity for polyhedra formation.
High-Speed Miniaturized Photodiode and Parallel-Fed Traveling-Wave Photodetectors Based on InP (2007)

A periodic parallel-fed traveling-wave photodetector (TWPD) with monolithically integrated power splitter is presented. The device exhibits an impedance match to the 50-Omega environment as well as a velocity match between the optical and electrical signals and shows a 3-dB bandwidth up to 85 GHz. The electrical output power reaches +10 dBm at 10 GHz. The device is based on evanescently coupled low-capacitance waveguide-integrated p-i-n photodiodes (PDs) with optimized optical matching layer which reveal a bandwidth of 145 GHz when employed as a stand-alone photodetector
Dynamic, Polymer-Integrated Crystals for Efficient, Reversible Protein Encapsulation (2022)

Crystalline materials are increasingly being used as platforms for encapsulating proteins to create stable, functional materials. However, the uptake efficiencies and stimuli-responsiveness of crystalline frameworks are limited by their rigidities. We have recently reported a new form of materials, polymer-integrated crystals (PIX), which combine the structural order of protein crystals with the dynamic, stimuli-responsive properties of synthetic polymers. Here we show that the crystallinity, flexibility, and chemical tunability of PIX can be exploited to encapsulate guest proteins with high loading efficiencies (up to 46% w/w). The electrostatic host-guest interactions enable reversible, pH-controlled uptake/release of guest proteins as well as the mutual stabilization of the host and the guest, thus creating a uniquely synergistic platform toward the development of functional biomaterials and the controlled delivery of biological macromolecules.
Regulation of B-CLL Apoptosis Through Membrane Receptors and Bcl-2 Family Proteins (1998)

The accumulation of monoclonal chronic lymphocytic leukemia B (B-CLL) cells may be due to excessive proliferation and longevity. Clinical progression may thus come from a constitutive but altered expression of a number of genes that results in extended B-CLL cells life span, increased proliferative capacity and diminished cell death. B-CLL cells express a number of surface markers that characterise the normal B-cells phenotype. However, B-CLL cells are CD5 positive and most of them also express CD6, surface receptors that are present in just a small subset of normal B-cells. When exploring CD6 function, we found out that cross-linking of CD6 protected B-CLL from anti-IgM-induced apoptosis. CD6 activation blocked anti-IgM- induced Bax(alpha) up-regulation and, by doing so, corrected an imbalance in the Bcl-2/Bax ratio that accompanies apoptosis. Here, we review all surface receptors and cytokines that have been described as participating in the induction or protection of B-CLL apoptosis together with data on chemosensitivity and gene modulation, data on the Fas receptor/Fas ligand system, and the implications of all the latter for B-CLL cell survival.
Quantum computing within the framework of advanced semiconductor manufacturing (2016)

Quantum computing holds the promise of exponential speedup compared to classical computing for select algorithms and applications. Relatively small numbers of logical quantum bits or qubits could outperform the largest of supercomputers. Quantum dots in Si-based heterostructures and superconducting Josephson junctions are just two of the many approaches to construct the qubit. These, in particular, bear similarities to the transistors and interconnects used in advanced semiconductor manufacturing. While initial results on few-qubit systems are promising, advanced process control is expected to improve the qubit uniformity, coherence time, and gate fidelity needed for larger systems. This can be realized through the systematic characterization of film growth, interface control, and patterning.
2,2-Diphenyl-1-picrylhydrazyl Radical-Scavenging Active Components from <i>Polygonum multiflorum</i> Thunb. (1999)

An activity-directed fractionation and purification process was used to identify the antioxidative components of Polygonum multiflorum Thunb. (PM). Dried root of PM was extracted with 95% ethanol and then separated into water, ethyl acetate, and hexane fractions. Among these only the ethyl acetate phase showed strong antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test when compared with water and hexane phases. The ethyl acetate fraction was then subjected to separation and purification using silica gel column chromatography and Sephadex LH-20 chromatography. Three compounds showing strong antioxidant activity were identified by spectral methods ((1)H NMR, (13)C NMR, and MS) and by comparison with authentic samples to be gallic acid, catechin, and 2,3,5, 4'-tetrahydroxystilbene 2-O-beta-D-glucopyranoside.
Combination of Light Annular-Mud Drilling and Downhole Isolation Valve for Drilling in Fractured Gas Reservoir, A Case Study (2017)

Abstract The South Sumatra Field in Indonesia produces from a high deliverability gas reservoir with the gas rate of each well around 50 to 200 MMSCFD. The primary target is the fractured network present in the Pre- tertiary Granite/Andesite while the secondary target is the Tertiary carbonate. In the past decade, Light Annular Mud Cap Drilling (LAMCD) is one of Manage Pressure Drilling (MPD) methods that has been frequently applied to drill in the surrounding areas of South Sumatra's oil and gas fields. The LAMCD method allows drilling to continue despite experiencing total loss of circulation in the fractured reservoir. Sacrificial fluid, usually fresh water, is injected down into the wellbore through the drill pipe. Viscous fluid with the density slightly lower than the pore pressure is injected intermittently into the annulus. The challenge occurs prior to tripping out where the well needs to be balanced. The killing operation contributes additional cost from the lost circulation materials, additional operation days or non-productive time (NPT) and inflicts damage into the reservoir due to the injected LCM. The downhole isolation valve (DIV) system is integrated into the 9-5/8″ casing string to cope with the challenge. By using this system, the requirement to kill the well while tripping out is eliminated. The successful utilization of LAMCD and DIV is elaborated in this paper as part of the drilling program and the combination of the two principles are applied. This paper focuses on the utilization of LAMCD and DIV in a case study of Drilling Well X which was drilled in the South Sumatra Field.
Randomized multicenter trial of cytosine arabinoside with mitoxantrone or daunorubicin in previously untreated adult patients with acute nonlymphocytic leukemia (ANLL). Lederle Cooperative Group. (1990)

This phase III, randomized trial in previously untreated adults with ANLL compared mitoxantrone plus cytosine arabinoside with the CALGB "7 + 3" daunorubicin-based regimen. Two hundred evaluable patients (98 treated with the mitoxantrone-based regimen and 102 with the daunorubicin-based regimen) were included in the analysis of efficacy. The median age of the patients was 60 years. The induction regimen comprised cytosine arabinoside 100 mg/m2 by infusion daily for 7 days and mitoxantrone 12 mg/m2 or daunorubicin 45 mg/m2 daily for days 1-3. If needed, a second induction course was administered: cytosine arabinoside for 5 days and mitoxantrone or daunorubicin for 2 days. Postremission therapy consisted of two consolidation courses, identical to the second induction course. Sixty-three percent (62 of 98) of patients treated with mitoxantrone achieved complete remission (CR), compared to 53% (54 of 102) treated with daunorubicin. The median time to CR was 35 days in patients treated with mitoxantrone and 43 days for those treated with daunorubicin. Eighty-nine percent (55 of 62) of patients treated with mitoxantrone who entered complete remission achieved CR following one induction course, compared to 68% (37 of 54) of patients treated with daunorubicin who entered CR. The median duration of CR was 240 days in patients treated with mitoxantrone and 198 days in those treated with daunorubicin; the median length of survival was 328 days in patients who received mitoxantrone and 247 days in those who received daunorubicin. The toxicity profiles in patients treated with either of the two regimens were comparable in incidence and in severity. Patients treated with mitoxantrone required fewer median platelet units and were treated with fewer median days of intravenous antibiotics, compared to those who received daunorubicin. Mitoxantrone in combination with cytosine arabinoside is effective in previously untreated ANLL. complete remissions occur more frequently after a single induction course of the mitoxantrone-based regimen, compared to the standard Cancer and Acute Leukemia Group B regimen. This should be explored in further trials.
Factors affecting the ATPase activity of chicken gizzard actomyosin (1982)

Conference Article| August 01 1982 Factors affecting the ATPase activity of chicken gizzard actomyosin HEATHER A. COLE; HEATHER A. COLE 1Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROGER J. A. GRAND; ROGER J. A. GRAND 2Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, U.K. Search for other works by this author on: This Site PubMed Google Scholar VALERIE B. PATCHELL; VALERIE B. PATCHELL 3Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, U.K. Search for other works by this author on: This Site PubMed Google Scholar S. VICTOR PERRY S. VICTOR PERRY 4Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1982) 10 (4): 237. https://doi.org/10.1042/bst0100237 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation HEATHER A. COLE, ROGER J. A. GRAND, VALERIE B. PATCHELL, S. VICTOR PERRY; Factors affecting the ATPase activity of chicken gizzard actomyosin. Biochem Soc Trans 1 August 1982; 10 (4): 237. doi: https://doi.org/10.1042/bst0100237 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1982 Biochemical Society1982 Article PDF first page preview Close Modal You do not currently have access to this content.
Epithelial-Mesenchymal Transition and Proliferation of Retinal Pigment Epithelial Cells Initiated upon Loss of Cell-Cell Contact (2010)

EMT and the onset of proliferation in RPE cells is initiated by loss of cell-cell contact. TGF-beta cannot initiate EMT or the proliferation of RPE cells maintaining cell-cell contact but appears to play an important secondary role downstream of EMT in inducing transition to a myofibroblast phenotype-a phenotype linked to the development of fibrotic complications.
Observations on the effects of germanium dioxide on the growth of macro-algae and diatoms (1982)

Growth of various species of macro-algae and diatoms was measured in culture in a range of concentrations of germanium dioxide. Growth of Laminaria saccharina was inhibited measurably at concentrations above 0.22 mg GeO2 l−1 and very markedly inhibited above 1.1 mg GeO2 l−1. Fucus spiralis was measurably inhibited at concentrations above 0.22 mg GeO2 l−1, as was Ulva lactuca at concentrations above 2.2 mg GeO2 l−1. The Rhodophyta tested (Polysiphonia urceolata, Porphyra umbilicalis, Chondrus crispus) showed no inhibition by GeO2. Most diatoms tested were strongly inhibited by concentrations of 0.134 mg GeO2 l−1. It is suggested that the majority of diatoms can be controlled without inhibiting the growth of most cultures of species of Phaeophyta or Chlorophyta by short-term application of GeO2 in concentrations of 0.045–0.179 mg GeO2 l−1 (0.01–0.04 ml sat. GeO2 soln. l−1) instead of the much higher concentrations previously suggested.
An Improved MPPT Algorithm for Photovoltaic Inverter (2016)

In order to effectively solve the shock and false error in frequently used perturbation method in maximum power point tracking (MPPT) for photovoltaic inverter, the working voltage of the PV array was adjusted to 80% at the initial stage of the maximum power point tracking(MPPT), During collecting its working current and voltage, the high frequency noise was filtered by FIR filter, and the direction of disturbance was determined by three-point mode, and the step size was adjusted with the change of light intensity. The experimental analysis indicates that the stability, precision and efficiency of the improved perturbation method were developed obviously.
A scalable offset-cancelled current/voltage sense amplifier (2010)

The application of current sense amplifiers in scaled SRAM design is limited by two factors: the DC offset due to the device mismatch and limited voltage headroom. The presented scheme reduces the effect of offset by proposing an extra phase for offset cancellation before current sensing takes place. A twofold reduction of the cell access time is achieved compared to the conventional scheme under similar cell current and bitline capacitance. The offset cancellation phase takes place in parallel to the wordline decoding time in order to speed up the current sensing. The proposed scheme requires a small power budget due to a self shut off mechanism. In addition to presenting a comparison with the conventional schemes, the efficiency of the proposed scheme is evaluated in 90nm, 130nm and 180nm CMOS technologies to show the scalability and the robustness of the proposed scheme under smaller voltage headroom.