gebhart/patrepeval huggingface dataset:
Chymopapain treatment of intervertebral disc disease (1975)

In the first of a two-part study, the authors review the known biochemical, pharmacological, toxicological, and experimental data concerning chymopapain and the intervertebral disc. They describe the action of this proteolytic enzyme, which apparently disrupts the protein mucopolysaccharide component of disc material, most marked in the nucleus pulposus. A rapid conversion to collagen causes a loss of disc space height; toxicity appears to result from alteration of bonding between capillary endothelial cells that in turn produces hemorrhage. Part 2 reviews significant reported results and complications of clinical chemonucleolysis.
ANTIMYCOPLASMA ACTIVITIES OF MACROLIDE ANTIBIOTICS (1972)

Comparative in vitro tests were carried out with 14 macloride antibiotics to determine their antimycoplasma activities, employing 2 mycoplasma strains derived from chikens and 7 strains from humans. It was found that a macrolide with a 16-membered lactone was more active than that with a 14-membered lactone. With respect to 8 leucomycins, those belonging to the Ac-group were more active than those of the Fr-group, and leucomycin A3 had the highest activity.
Atomically-thin van der Waals Heterostructure Solar Cells (2015)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. Mueller, M. Furchi, A. Zechmeister, S. Schuler, and A. Pospischil, "Atomically-thin van der Waals Heterostructure Solar Cells," in CLEO: 2015, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper FTh3E.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
PEComa: A Perivascular Epithelioid Cell Tumor in the Liver—A Case Report and Review of the Literature (2013)

Perivascular epithelioid cell tumors are soft tissue tumors that can occur in various locations in the body whose incidence is rising. Hepatic PEComas are quite rare and diagnosis involves positivity of Melan-A and HMB45 on immunohistochemistry. Usual treatment is surgery for benign tumors and chemotherapy including mTOR inhibitors for malignant tumors. Here we discuss the radiological and pathological diagnosis, evaluation, and management of a hepatic PEComa. We describe a 51-year-old patient who was diagnosed incidentally after unusual physical exam findings.
3D Convolutional Neural Network Based on Face Anti-spoofing (2017)

Face anti-spoofing is very significant to the security of face recognition. Many existing literatures focus on the study of photo attack. For the video attack, however, the related research efforts are still insufficient. In this paper, instead of extracting features from a single image, features are learned from video frames. To realize face anti-spoofing, the spatiotemporal features of continuous video frames are extracted using 3D convolution neural network (CNN) from the short video frame level. Experimental results show that the two sets of face anti-spoofing public databases, Replay-Attack and CASIA, have achieved the HTER (Half Total Error Rate) of 0.04% and 10.65%, respectively, which is better than the state-of-the-art.
THE IDENTIFICATION OF N-(2-HYDROXYETHYL)-PALMITAMIDE AS A NATURALLY OCCURRING ANTI-INFLAMMATORY AGENT (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE IDENTIFICATION OF N-(2-HYDROXYETHYL)-PALMITAMIDE AS A NATURALLY OCCURRING ANTI-INFLAMMATORY AGENTF. A. Kuehl Jr., T. A. Jacob, O. H. Ganley, R. E. Ormond, and M. A. P. MeisingerCite this: J. Am. Chem. Soc. 1957, 79, 20, 5577–5578Publication Date (Print):October 1, 1957Publication History Published online1 May 2002Published inissue 1 October 1957https://pubs.acs.org/doi/10.1021/ja01577a066https://doi.org/10.1021/ja01577a066research-articleACS PublicationsRequest reuse permissionsArticle Views352Altmetric-Citations169LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of polyols and sugars on heat-induced flavin dissociation in glucose oxidase. (1994)

A thermodynamic investigation was carried out on heat-induced flavin dissociation in Aspergillus niger glucose oxidase. Experimental measurements performed by difference spectroscopy showed that the dissociation of the FAD cofactors is a highly cooperative process and is probably related to the extended conformational changes resulting from protein unfolding. Microenvironmental modifications attained by the addition of polyhydric compounds (glycerol, fructose, sucrose and sorbitol) from 10 to 30% by weight were found to hinder the dissociation. The stabilizing effect provided by these substances was interpreted as a consequence of preferential exclusion phenomena, which are likely to be determined by the perturbation of the surface tension of water, in the case of sugars, or by the solvophobic effect, in the case of glycerol.
Randomized Polypill Crossover Trial in People Aged 50 and Over (2012)

Controlled-Trials.com ISRCTN36672232.
Androgen, estrogen, and progesterone receptors in normal and aging prostates (1995)

Testicular hormones regulate the growth and development of the prostate. The presence of androgen receptors in prostatic tissue and their importance in the normal development of the prostate has been established. Age-related changes in the hormonal milieu, and perhaps steroid hormone receptor profile, could set in motion pathological changes leading to the onset of benign prostatic hyperplasia (BPH) or prostate cancer which primarily affect older men. The accumulation of dihydrotestosterone with age, the reawakening of the inductive potential of the prostatic stroma, the altered rate of apoptosis with age, and the age-related changes in the ratio of testosterone:estrogen have all been implicated in the etiology of BPH. In addition to androgen receptors, several studies have documented the presence of estrogen and progesterone receptors in BPH and prostate cancer. So far, most studies have focussed on the correlation between the presence/absence of steroid hormone receptors and response to hormonal therapy. The molecular mechanisms by which these steroid hormone receptors regulate the onset or progression of BPH and prostate cancer are not yet clear. The chronological changes in the levels and distribution of steroid hormone receptors in normal prostatic tissue and the effect of such changes on the synthesis of growth factors, growth factor receptors, and oncogenes should be investigated.
Structure, Organization, and Regulation of the Complement Genes (1988)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Reasons to Use Virtual Reality in Education and Training Courses and a Model to Determine When to Use Virtual Reality. (2010)

Many studies have been conducted on the use of virtual reality in education and training. This article lists examples of such research. Reasons to use virtual reality are discussed. Advantages and disadvantages of using virtual reality are presented, as well as suggestions on when to use and when not to use virtual reality. A model that can be used to determine when to use virtual reality in an education or training course is presented.
EXPERIMENTAL STUDY ON RECOVERY OF SPENT HYDROCRACKING CATALYST (2009)

The spent catalysts are one of the environmental concerns in the refineries. This problem can be solved by returning them to the process via regenerating and rejuvenating. In this paper, an experimental study is presented which the recovery of spent catalyst of hydrocracking unit in order to use in kerosene hydrotreatment process is investigated. The result shows that the regenerated catalyst is suitable for kerosene HDS at 300°C, 35 bar and H2/HC=100.
Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol (2002)

Oxidized LDL (OxLDL) is composed of many potentially proatherogenic molecules, including oxysterols. Of the oxysterols, 7-ketocholesterol (7-KC) is found in relatively large abundance in OxLDL, as well as in atherosclerotic plaque and foam cells in vivo. Although there is evidence that 7-KC activates endothelial cells, its effect on monocytes is unknown. We tested the hypothesis that 7-KC may induce monocyte differentiation and promote foam cell formation. THP-1 cells were used as a monocyte model system and were treated with 7-KC over a range of concentrations from 0.5 to 10 microg/ml. Changes in cell adhesion properties, cell morphology, and expression of antigens characteristic of differentiated macrophages were monitored over a 7-day period. 7-KC promoted cells to firmly adhere and display morphologic features of differentiated macrophages; this effect was time and dose dependent and was markedly more potent than cholesterol treatment (45% of cells became adherent after 7 days of treatment with 7-KC at 10 microg/ml vs. less then 5% for control cells, P < 0.01). Similar effects were obtained when LDL enriched with 7-KC or OxLDL were added to THP-1 cells. 7-KC-differentiated cells expressed CD11b, CD36, and CD68, phagocytized latex beads, and formed lipid-laden foam cells after exposure to acetylated LDL or OxLDL. In contrast to 7-KC, oxysterols with known cell regulatory effects such as 25-hydroxycholesterol, 7beta-hydroxycholesterol, and (22R)-hydroxycholesterol did not effectively promote THP-1 differentiation. In conclusion, these results demonstrate for the first time that 7-KC, a prominent oxysterol formed in OxLDL by peroxidation of cholesterol, may play an important role in promoting monocyte differentiation and foam cell formation. These studies also suggest that 7-KC induces monocyte differentiation through a sterol-mediated regulatory pathway that remains to be characterized.
Recordings (1980)

Journal Article Recordings Get access Les Musidens de ProvenceInstruments Anciens: Musique des Trouveres et Troubadours (vol 1) Joculatores UpsaliensesEarly Musical Wik LEECH-WILKINSON DANIEL LEECH-WILKINSON DANIEL Search for other works by this author on: Oxford Academic Google Scholar Early Music, Volume 8, Issue 2, April 1980, Pages 262–265, https://doi.org/10.1093/earlyj/8.2.262 Published: 01 April 1980
ASCUS-LSIL Triage Study (2000)

The successful enrollment, randomization and high rates of follow-up are encouraging. The study will help clarify the optimal strategies for managing low grade cervical abnormalities.
PROLONGATION OF ISLET ALLOGRAFT SURVIVAL (1979)

Pretreatment of donor rats with irradiation and silica followed by in vitro culture of the islets for 1 to 2 days prolonged survival of allografts across a minor histocompatibility barrier if "hand-picked," clean islets were used for transplantation. Pretreatment of donor rats with irradiation and silica in conjunction with a single injection of antilymphocyte serum (ALS) into the recipient produced a prolongation of survival of hand-picked islets transplanted across a major histocompatibility barrier.
The Chemical and Biologic Profile of a Red Clover ( <i>Trifolium pratense</i> L.) Phase II Clinical Extract (2006)

The major and minor chemical and active estrogenic components of a preformulated phase II red clover clinical extract were identified, quantitatively measured, and the final capsule doses were calculated. The extract is currently under evaluation in a year-long clinical study for the alleviation of menopausal hot flashes. This is the first report to thoroughly summarize the chemistry and biology of all major peaks observed in the HPLC-UV chromatogram of a clinical red clover dietary supplement.
Energy-band alignment of II-VI/Zn3P2 heterojunctions from x-ray photoemission spectroscopy (2013)

The energy-band alignments for zb-ZnSe(001)/α-Zn3P2(001), w-CdS(0001)/α-Zn3P2(001), and w-ZnO(0001)/α-Zn3P2(001) heterojunctions have been determined using high-resolution x-ray photoelectron spectroscopy via the Kraut method. Ab initio hybrid density functional theory calculations of the valence-band density of states were used to determine the energy differences between the core level and valence-band maximum for each of the bulk materials. The ZnSe/Zn3P2 heterojunction had a small conduction-band offset, ΔEC, of −0.03 ± 0.11 eV, demonstrating a nearly ideal energy-band alignment for use in thin-film photovoltaic devices. The CdS/Zn3P2 heterojunction was also type-II but had a larger conduction-band offset of ΔEC = −0.76 ± 0.10 eV. A type-III alignment was observed for the ZnO/Zn3P2 heterojunction, with ΔEC = −1.61 ± 0.16 eV indicating the formation of a tunnel junction at the oxide–phosphide interface. The data also provide insight into the role of the II-VI/Zn3P2 band alignment in the reported performance of Zn3P2 heterojunction solar cells.
Are fatigue and disturbances in pre‐programmed activity of pelvic floor muscles associated with female stress urinary incontinence? (2004)

Muscular fatigue, defined as rate of force loss, does not seem to be associated with urinary stress incontinence. Moreover, muscular activity recruitment patterns were equal in both groups suggesting that other factors than disturbances of ordered muscle recruitment, that is, pelvic floor followed by abdominal muscles, may be responsible for stress urinary incontinence. It is likely that reduced normalized force, as found in the incontinent group, is an important contributing factor.
Help for Laboring Teachers... (1934)

How well do I remember how much it meant to me when I was a young teacher to find a book on methods of teaching some subject over which I was laboring.
Automated QT interval analysis with confidence measures (2005)

Current automated methods for QT interval analysis suffer from the absence of a confidence value in the resulting measurements. In this paper we present a new approach to QT interval analysis, which produces both a segmentation of the ECG together with an associated measure of confidence in the segmentation. The method is based on a novel hidden Markov model architecture, which is designed to prevent unrealistic segmentations. We utilise the probabilistic nature of the model to derive a confidence measure based upon the log likelihood of the ECG waveform under consideration. The method is demonstrated on an ECG signal containing an ectopic beat, and an ECG contaminated by muscle artefact noise.
<i>N</i>-Tetradecylcarbamyl Lipopeptides as Novel Agonists for Toll-like Receptor 2 (2014)

New analogues (UPam) of triacylated lipopeptide Pam3CysSK4, a popular agonist of Toll-like receptor 2 (TLR2), were designed making use of the cocrystal structure of a TLR2 heterodimer (with TLR1) with Pam3CysSK4. Twenty-two UPam derivatives that feature an N-tetradecylcarbamyl chain to mimic the native N-palmitoyl moiety and various small amino acids residues at the penultimate N-terminal position were prepared via solid-phase synthesis. In vitro evaluation of immunostimulatory properties revealed new potent TLR2 ligands.
Calcium binding capacity of the cytosol and endoplasmic reticulum of mouse pancreatic acinar cells (1999)

1. The droplet technique was used in this study to measure total calcium loss from pancreatic acinar cells due to calcium extrusion. The calcium binding capacity of the cytosol (kc) was measured as the ratio of the decrease in the total calcium concentration of the cytosol of the cell (Delta[Ca]c) and the synchronously occurring decrease in the free calcium ion concentration in the cytosol (Delta[Ca2+]c). The calcium dependency of the calcium binding capacity was determined by plotting values of kc against the corresponding [Ca2+]c. The rise in the cytosolic Ca2+ concentration of pancreatic acinar cells was triggered by stimulation with a supramaximal dose of cholecystokinin (CCK). The recovery of [Ca2+]c during continued exposure to the agonist was due to calcium extrusion from the cell. 2. The calcium binding capacity was about 1500-2000 for the [Ca2+]c range 150-500 nM. The mechanism of buffering was not investigated in this study. The calcium binding capacity of the cytosol did not vary significantly with [Ca2+]c in this range. The CCK-evoked decrease in the total calcium concentration in the lumen of the endoplasmic reticulum (ER) can be estimated from our data, taking into account previously published values for the volume of the ER in pancreatic acinar cells. Comparing the decrease in the total ER calcium concentration with our recently reported values for agonist-induced reductions in the free Ca2+ concentration inside the ER, we estimate that the calcium binding capacity of the ER is approximately 20. In pancreatic acinar cells we have therefore found a difference of two orders of magnitude in the efficiency of calcium buffering in the cytosol and the ER lumen.
Polypharmacy in Elderly Patients With Diabetes (2002)

In Brief Elderly diabetic patients often require multiple medications to adequately and appropriately treat their diabetes and associated comorbidities. Careful attention to avoiding drug interactions, limiting unnecessary medications, and choosing drugs most appropriate for elderly patients will lead to optimal outcomes.
51.2: A. 4.3‐in. VGA (188 ppi) AMOLED Display with a New Driving Method (2004)

Abstract We developed a 4.3‐inch VGA driver‐integrated AM‐OLED display with the world's highest pixel density of 188ppi by using high performance TFTs, a top emission structure, a technology for improving the precision of mask alignment in OLED deposition by RGB emitter's selective deposition method, and a 4Tr/Cell digital time‐gray‐scale driving method which improves image quality by fixing the gate potential of driving TFT.
PD1/PD-L1 inhibition as a potential radiosensitizer in head and neck squamous cell carcinoma: a case report (2016)

T cell activation induced by checkpoint inhibition may dramatically improve tumor response to radiation. More data are needed to identify the toxicity and efficacy of sequential or concurrent checkpoint inhibitors and radiotherapy.
A novel (    ) -thalassemia deletion associated with an   globin gene triplication leading to a severe transfusion dependant fetal thalassemic syndrome (2009)

A novel (εγδβ)°-thalassemia deletion associated with an α globin gene triplication leading to a severe transfusion dependant fetal thalassemic syndrome
SARS-CoV-2 Variants of Concern in the United States—Challenges and Opportunities (2021)

Wenjuan Zhang, PhD; Brian D. Davis, BSc; Stephanie S. Chen, BSc; Jorge M. Sincuir Martinez, BS; Jasmine T. Plummer, PhD; Eric Vail, MD
[Efficacy of intensive manual therapy in severe multiple trauma]. (2005)

How intensive rehabilitation influences external respiration function, central and peripheral hemodynamics in the injured with a severe multitrauma was investigated in 71 injured. Intensive rehabilitation in combined treatment is shown to improve external respiration function, central hemodynamics, tissue blood flow, sleep, appetite, healing of bedsores, to enhance cough reflex.
Engraftment Syndrome in Hematopoietic Stem Cell Transplantations (2014)

Hematopoietic stem cell transplantation (HSCT) is an increasingly common treatment option for malignant and nonmalignant diseases, but it has significant associated morbidity and mortality. Nurses caring for HSCT recipients must be aware of all potential complications, including engraftment syndrome (ES). Previous nursing literature has included little information on this syndrome, which often presents with noninfectious fever, skin rash, and pulmonary infiltrates, and ES may be fatal if left unidentified and treatment is not initiated promptly. Reports of the risk factors, incidence, clinical manifestations, diagnosis, treatment, and outcomes have much variation, likely from a lack of definite diagnostic criteria and inconsistency in the terminology associated with ES. The purpose of this article is to provide an overview of ES and the implications for nursing practice and research.
A bibliography of temporal, spatial and spatio-temporal data mining research (1999)

With the growth in the size of datasets, data mining has recently become an important research topic and is receiving substantial interest from both academia and industry. At the same time, a greater recognition of the value of temporal and spatial data has been evident and the first papers looking at the confluence of these two areas are starting to emerge. This short paper provides a few comments on this research and provides a bibliography of relevant research papers investigating temporal, spatial and spatio-temporal data mining.
c-myb Transactivates the Human Cyclin A1 Promoter and Induces Cyclin A1 Gene Expression (1999)

Cyclin A1 differs from other cyclins in its highly restricted expression pattern. Besides its expression during spermatogenesis, cyclin A1 is also expressed in hematopoietic progenitor cells and in acute myeloid leukemia. We investigated mechanisms that might contribute to cyclin A1 expression in hematopoietic cells. Comparison of cyclin A1 and cyclin A promoter activity in adherent and myeloid leukemia cell lines showed that the cyclin A1 promoter is preferentially active in myeloid cell lines. This preferential activity was present in a small, 335-bp cyclin A1 promoter fragment that contained several potential c-myb binding sites. Coexpression of a c-myb expression vector with the cyclin A1 promoter constructs significantly increased the reporter activity in adherent CV-1 as well as in myeloid U937 cells. Gel-shift assays demonstrated that c-myb could bind to the cyclin A1 promoter at a binding site located near the transcription start site. Site-directed mutagenesis of this site decreased promoter transactivation by 50% in both KCL22 cells that express high levels of c-myb and in CV-1 cells that were transfected with c-myb. In addition, transfection of primary human embryonic fibroblasts with a c-myb expression vector led to induction of the endogenous cyclin A1 gene. Taken together, c-myb can directly transactivate the promoter of cyclin A1, and c-myb might be involved in the high-level expression of cyclin A1 observed in acute myeloid leukemia. These findings suggest that c-myb induces hematopoiesis-specific mechanisms of cell cycle regulation.