gebhart/patrepeval huggingface dataset:
iTrack: Correlating user activity with system data (2012)

Human error has been identified one of the major factors behind system outages and network downtime in a number of previous research papers and surveys. Gartner statistics show that almost 40% of unplanned application downtime is caused due to operator errors such as unintentional changes to network configuration resulting in a network outage, patch installations, service restart, etc. Yet, system admin activities on production IT systems are rarely properly logged and monitored. Existing tools to track user activities either produce too much information without any hints of a potential outage scenario or too little information to be useful in a meaningful way. In this paper, we describe the design and implementation of iTrack - a framework for monitoring user activities and correlating them with system data. iTrack makes use of commonly available native monitoring and diagnostic utilities on operating systems to monitor systems events as well as system admin activity, correlates these two sets of information and categorizes the activity as potentially abnormal or harmful based on its impact on the system in terms of file system, network and process activities. We demonstrate the usefulness of iTrack through several use cases and real world examples such as detecting and diagnosing system outages in real time, conducting post mortem analysis of outages, and maintaining audit logs. Our experimental evaluation of iTrack confirms that its monitoring overhead in terms of CPU time, activity completion time and data generated is within the tolerance range of most production systems. In cases, where the overhead was found to be unacceptable, we detect the underlying cause and provide solutions. These solutions improve performance by up to 20% to 90%, in terms of managed server and iTrack server CPU utilization, respectively and by up to 2 times in terms of completion time of certain system admin activities on the managed server.
Recursively indexed quantization of memoryless sources (1992)

A recursively indexed scalar quantizer that performs as well as high-dimensional vector quantizers for several important sources, without the attendant complexity, is presented. The recursively indexed quantizer provides a simple technique, both in terms of design and operation, for use with entropy coding. It also provides a simple quantization technique for use in noisy channel conditions where a variable length code would be inappropriate but performance greater than that provided by Lloyd-Max quantizers is desired.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Convenient method for detecting 14CO2 in multiple samples: application to rapid screening for mutants (1976)

A procedure is presented for the rapid screening of bacterial colonies to detect mutants unable to produce 14CO2 from a labeled precursor. The method is especially useful for mass screening for mutants that cannot be easily detected by their phenotypic characteristics.
Coherent Polarization-Division-Multiplexed QPSK Receiver With Fractionally Spaced CMA for PMD Compensation (2008)

A digital coherent polarization-division-multiplexed quadrature phase-shift keying receiver with a fractionally spaced constant modulus algorithm (CMA) is implemented in a field-programmable gated array. Real-time measurements at 5 Gb/s demonstrate that polarization-mode dispersion can be effectively compensated with multiple numbers of taps when the received data is two-fold over-sampled. With a four-tap CMA, the 1-dB optical signal-to-noise ratio penalty point extends up to differential group delay of five times effective bit width (inverse of data rate at 5 Gb/s).
Learning Over Time: A Literature Review and Case Study (2007)

This is the publisher's version, also found at http://ehis.ebscohost.com/ehost/detail?sid=311dd0cd-6ea1-4d5c-8de0-704b9260d750%40sessionmgr10&vid=1&hid=17&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=s3h&AN=26633927
More About Arc-Fault Circuit Interrupters (2004)

Since the arc-fault circuit interrupter (AFCI) was commercially introduced in 1998, questions have arisen about how it detects arcs, whether it detects series and parallel arcs, and what types of AFCIs are available. Types other than the original branch/feeder AFCI are emerging. This paper is intended to provide an update regarding answers to those questions, following an earlier paper that introduced the basic functioning of the AFCI.
Protective role of systemic furin in immune response–induced arthritis (2012)

These findings show the protective role of exogenous furin against RA, mediated by an immune response. The data suggest the potential therapeutic use of furin or its derivatives in autoimmune diseases including RA.
Current Practice Patterns in the Management of Upper Urinary Tract Calculi in the North Central United States (2008)

The results of this survey suggest that practice patterns for treatment of stone disease match the treatment approach recommended in the published literature. This information can be further utilized for assessment of guidelines for the treatment of stone disease.
Distributed Storage Meets Secret Sharing on the Blockchain (2018)

Blockchain systems establish a cryptographically secure data structure for storing data in the form of a hash chain. We use a novel combination of distributed storage, private key encryption, and Shamirs secret sharing scheme to distribute transaction data, without significant loss in data integrity. Additionally, using Shamirs secret sharing scheme on the hash values and dynamic zone allocation, we further enhance the integrity. We highlight the tradeoff in storage cost and data loss probability with varying zone size choices. We also study the tradeoff between recovery cost and security from adversarial corruption with varying recovery mechanisms. Then, we formulate code design, given a probability of data recovery and targeted corruption, as an integer program. Using the coding scheme we establish a mechanism to insure data, for instance in blockchain-based cloud storage systems, based on the value of the data, by understanding the costs involved for the service provider.
Electrochemical Signatures of Interface-Dominated Behavior in the Testing of Calcium Foil Anodes (2020)

Fundamental research and practical assembly of rechargeable calcium (Ca) batteries will benefit from an ability to use Ca foil anodes. Given that Ca electrochemistry is considered a surface-film-controlled process, understanding the interface's role is paramount. This study examines electrochemical signatures of several Ca interfaces in a benchmark electrolyte, Ca(BH<sub>4</sub>)<sub>2</sub>/tetrahydrofuran (THF). Preparation methodologies of Ca foils are presented, along with Ca plating/stripping through either pre-existing, native calcium hydride (CaH<sub>2</sub>), or pre-formed calcium fluoride (CaF<sub>2</sub>) interfaces. In contrast to earlier work examining Ca foil in other electrolytes, Ca foils are accessible for reversible electrochemistry in Ca(BH<sub>4</sub>)<sub>2</sub>/THF. However, the first cyclic voltammetry (CV) cycle reflects persistent, history-dependent behavior from prior handling, which manifests as characteristic interface-derived features. This behavior diminishes as Ca is cycled, though formation of a native interface can return the CV to interface-dominated behavior. CaF<sub>2</sub> modification enhances such interface-dominance; however, continued cycling suppresses such features, collectively indicating the dynamic nature of certain Ca interfaces. Cell configuration is also found to significantly influence electrochemistry. With appropriate preparation of Ca foils, the signature of interface-dominated behavior is still present during the first cycle in coin cells, but higher current density compared to three-electrode cells along with moderate cycle life are readily achievable.
Marked antiinflammatory effects of decentralization of the superior cervical ganglia. (1990)

Intravenous challenge with parasite antigens in Nippostrongylus brasiliensis-sensitized rats resulted in anaphylactic shock and, in some animals, death. Surviving animals showed significant drop in mean arterial blood pressure, cardiac output, and blood flow to the trachea, bronchioles, and mesentery. After anaphylaxis, changes in the cellular and protein composition in bronchoalveolar lavage fluids (BALF) were assessed. 8 h after antigen challenge, there was significant influx of inflammatory cells and an increase in the levels of histamine and serum-derived immunoglobulins (IgG and IgM) in BALF. Chemotactic activity for neutrophils was also present in BALF. Once we established this anaphylaxis-induced model of pulmonary inflammation, we sought to determine whether or not the superior cervical ganglia (SCG) modulate this inflammation. We performed bilateral superior cervical ganglionectomy or decentralization of the SCG. Our results show that decentralization significantly reduced mortality (by 68%) after anaphylaxis. Furthermore, the increases in levels of serum-derived proteins, histamine, and influx of cells (especially neutrophils) observed in BALF after anaphylaxis were attenuated by both decentralization and ganglionectomy. By contrast, hemodynamic parameters in the respiratory tract and the presence of neutrophil chemotactic activity in BALF were not influenced by decentralization. Thus, the severity of pulmonary inflammation initiated by systemic anaphylaxis is depressed by bilateral ganglionectomy or decentralization of SCG.
Crude Oil Emulsions: A State-of-the-Art Review (2002)

Abstract Formation of emulsions during oil production is a costly problem, both in terms of chemicals used and due to production losses. This paper discusses production and operational problems related to crude oil emulsions, and present a review that will be very useful for practicing engineers. The first part of this paper presents why emulsions form during oil production, the types of emulsions encountered, and new methods for characterizing them. Crude oil emulsions are stabilized by rigid interfacial films that form a "skin" on water droplets and prevent the droplets from coalescing. The stability of these interfacial films, and hence the stability of the emulsions, depends on a number of factors including the heavy polar material in the crude oil (asphaltenes, resins, waxes, etc), solids (clays, scales, corrosion products, etc), temperature, drop size and drop size distribution, pH, oil and brine composition. These effects on emulsion stability are reviewed. The second part of this paper presents ways to tackle crude oil emulsions. The focus is on the destabilization of emulsions and the demulsification process. Emulsions are destabilized by increasing temperature and residence time, removal of solids, and controlling emulsifiers. The mechanisms involved in demulsification (flocculation, aggregation, sedimentation, creaming, and coalescence) are discussed in terms of the stability of the interfacial films. The methods involved in demulsification including thermal, mechanical, electrical, and chemical are also presented. Experience and economics determine which methods and to what degree each method is used for emulsion treatment. Finally, a section on field applications is included that should be useful for the practicing engineer who deals with emulsions, either regularly or on a limited basis. Herein the field emulsion treatment program is discussed, and more importantly, methods to prevent emulsion problems are highlighted. Recommendations are made for reducing and optimizing demulsifier dosage and controlling emulsion problems.
Fe2O3/carbon quantum dots complex photocatalysts and their enhanced photocatalytic activity under visible light (2011)

In this study, we report the facile fabrication of Fe(2)O(3)/CQDs nanocomposites, and investigate their effective photocatalytic activity for the photodegradation of toxic gas (gas-phase benzene and methanol) under visible light. The crucial roles of CQDs in the enhancement of photocatalytic activity of the Fe(2)O(3)/CQDs composites are illustrated.
A review of hemoglobin and the pathogenesis of cerebral vasospasm. (1991)

We believe that current experimental and clinical evidence can be most satisfactorily interpreted by assuming that oxyhemoglobin is the cause of cerebral vasospasm that follows subarachnoid hemorrhage. We review the pathogenetic mechanisms by which oxyhemoglobin affects cerebral arteries. The relative importance of each of these mechanisms in the genesis of vasospasm, the biochemical pathways of oxyhemoglobin-induced smooth muscle contraction, and the intracellular actions of oxyhemoglobin on smooth muscle and on other cells in arteries are still not definitely established.
Insertion of N-linked glycosylation sites in the variable regions of the human immunodeficiency virus type 1 surface glycoprotein through AAT triplet reiteration (1994)

Variable regions with sequence length variation in the human immunodeficiency virus type 1 envelope exhibit an unusual pattern of codon usage with AAT, ACT, and AGT together composing > 70% of all codons used. We postulate that this distribution is caused by insertion of AAT triplets followed by point mutations and selection. Accumulation of the encoded amino acids (asparagine, serine, and threonine) leads to the creation of new N-linked glycosylation sites, which helps the virus to escape from the immune pressure exerted by virus-neutralizing antibodies.
Th1-Like Cytokine Induction by Heat-Killed <i>Brucella abortus</i> Is Dependent on Triggering of TLR9 (2005)

In this report we provide evidence, for the first time, that bacterial DNA in the context of heat-killed Brucella abortus (HKBA) engages TLR9 in dendritic cells (DC), resulting in a Th1-like cytokine response. This is based on the findings that HKBA induction of IL-12p40 is: 1) abolished in DC from TLR9(-/-) mice; 2) blocked by suppressive oligodeoxynucleotides; 3) simulated by bacterial DNA derived from HKBA; and 4) abrogated by DNase or methylation of the DNA from HKBA. Furthermore, the effect of HKBA can be inhibited by chloroquine, indicating that endosomal acidification is required and supporting the notion that DNA from HKBA is interacting with TLR9 at the level of the endosome, as is the case with CpG oligodeoxynucleotides. In addition to DC, HKBA can elicit IL-12p40 secretion from macrophages, in which case the effect is wholly MyD88 dependent but only partially TLR9 dependent. This probably explains why HKBA effects in vivo are only partially reduced in TLR9(-/-), but absent in MyD88(-/-) mice. Because of their intimate interactions with T cells, the DC response is most likely to be critical for linking innate and adaptive immune responses, whereas the macrophage reaction may play a role in enhancing NK cell and bystander immune responses. In addition to IL-12p40, HKBA induces other Th1-like cytokines, namely, IFN-alpha and IFN-gamma, in a TLR9-dependent manner. These cytokines are important in protection against viruses and bacteria, and their induction enhances HKBA as a potential carrier for vaccines.
Potential autocrine and paracrine mechanisms of recovery from mechanical injury of renal tubular epithelial cells (1998)

The present studies were done to clarify potential pathways of the nephrogenic repair process. Media removed from mechanically injured vascular smooth muscle cells and LLC-PK1 renal tubular epithelial cells significantly stimulated [3H]thymidine uptake and cell number in quiescent LLC-PK1 cells, demonstrating the existence of potential autocrine and paracrine pathways of nephrogenic repair. The effect of mechanical injury resulting in release of one or more growth factors into culture media was also found in the opossum kidney OK renal tubular cell line. The nonspecific peptide growth factor antagonist suramin inhibited the effect of media from injured LLC-PK1 cells to stimulate [3H]thymidine uptake in quiescent LLC-PK1 cells. Exposure of quiescent LLC-PK1 cells to six growth factors, including acidic and basic fibroblastic growth factors (aFGF and bFGF), platelet-derived growth factors AA and BB (PDGF-AA and PDGF-BB), endothelin-2, and hepatocyte growth factor, reproduced the biological responses seen when quiescent LLC-PK1 cells were exposed to media from injured cells. Immunoblotting and enzyme-linked immunosorbent assay experiments demonstrated the presence of aFGF, bFGF, and PDGF-BB but not other candidate growth factors in the media from injured LLC-PK1 cells. A neutralizing antibody directed against bFGF attenuated the effect of media from injured cells to stimulate [3H]thymidine uptake in serum-starved LLC-PK1 cells. These results demonstrate that mechanical injury to renal tubular epithelial cells results in release of aFGF, bFGF, and PDGF-BB into the media and suggests that bFGF may be involved in an autocrine fashion to promote recovery from injury.
Plasma RNA as an alternative to cells for monitoring molecular response in patients with chronic myeloid leukemia (2007)

Background and Objectives : Quantitation of BCR-ABL mRNA is emerging as the standard of care to monitor the status of chronic myeloid leukemia (CML). Peripheral blood plasma was analyzed in this study because of previous detection of nucleic acids and proteins from tumor cells in plasma samples.Design and Methods : Reverse transcriptase polymerase chain reaction was used to establish ratios of BCR-ABL:ABL mRNA in peripheral blood cells and plasma, and absolute levels of BCR-ABL mRNA per unit volume of plasma. Samples from 160 CML patients and 180 control individuals without CML were tested. Cells and plasma samples from 93 of the CML patients were re-analyzed 3–12 months after imatinib treatment.Results : Ratios of BCR-ABL:ABL mRNA in paired cell and plasma samples of the 160 CML patients correlated significantly (r=0.83; p
Chemoselective Pd-Catalyzed Oxidation of Polyols: Synthetic Scope and Mechanistic Studies (2013)

The regio- and chemoselective oxidation of unprotected vicinal polyols with [(neocuproine)Pd(OAc)]2(OTf)2 (1) (neocuproine = 2,9-dimethyl-1,10-phenanthroline) occurs readily under mild reaction conditions to generate α-hydroxy ketones. The oxidation of vicinal diols is both faster and more selective than the oxidation of primary and secondary alcohols; vicinal 1,2-diols are oxidized selectively to hydroxy ketones, whereas primary alcohols are oxidized in preference to secondary alcohols. Oxidative lactonization of 1,5-diols yields cyclic lactones. Catalyst loadings as low as 0.12 mol % in oxidation reactions on a 10 g scale can be used. The exquisite selectivity of this catalyst system is evident in the chemoselective and stereospecific oxidation of the polyol (S,S)-1,2,3,4-tetrahydroxybutane [(S,S)-threitol] to (S)-erythrulose. Mechanistic, kinetic, and theoretical studies revealed that the rate laws for the oxidation of primary and secondary alcohols differ from those of diols. Density functional theory calculations support the conclusion that β-hydride elimination to give hydroxy ketones is product-determining for the oxidation of vicinal diols, whereas for primary and secondary alcohols, pre-equilibria favoring primary alkoxides are product-determining. In situ desorption electrospray ionization mass spectrometry (DESI-MS) revealed several key intermediates in the proposed catalytic cycle.
Microspherical surfaces with predefined focal lengths fabricated using microfluidic capillaries (2003)

We demonstrate a technique to fabricate spherical micromirrors with a programmable focal length by microfluidic capillary. Micromirrors with focal lengths of 13 μm, 19 μm, 28 μm, 50 μm, and a flat mirror were fabricated and characterized. These micromirrors show a great ability to converge light into a focal point. This technique also introduces the concept of fabricating and integrating optical components with microfluidic channels.
Preparation and properties of melt‐mixed metallocene polyethylene/silica nanocomposites (2010)

Abstract Metallocene polyethylene (mPE)/silica nanocomposites were prepared via melt mixing. Two types of commercial fumed nanosilica, bare silica (A200) and organic modified silica (R974), were incorporated to improve the mechanical properties of the nanocomposites. Transmission electron microscopy, atomic force microscopy, and scanning electron microscopy revealed that the modified silica was dispersed slightly better within the mPE matrix. No distinct effects on the thermal behaviors of the fast‐crystallizing mPE matrix were observed with variations in both the silica dosages and types. Thermal stability was enhanced through the addition of nanosilica, with or without surface treatment. The surface‐modified silica system showed slightly higher tensile strength and Young's modulus compared with the bare silica system, as evidenced by a rheological study using a Cole‐Cole plot to assess enhanced polymer matrix‐dispersed silica interactions, especially for high dosages of organic modified silica. A limited increment in the dynamic storage modulus for modified silica cases, completely opposite of that observed for bare silica cases, was due to the low‐aspect ratio of smaller agglomerates from highly dispersed organic modified silica within the mPE matrix. POLYM. ENG. SCI., 2011. © 2010 Society of Plastics Engineers.
Role of Fas Ligand and Receptor in the Mechanism of T-Cell Depletion in Acquired Immunodeficiency Syndrome: Effect on CD4+ Lymphocyte Depletion and Human Immunodeficiency Virus Replication (1997)

Direct killing of CD4+ lymphocytes by human immunodeficiency virus-1 (HIV-1) probably cannot account for the magnitude of the loss of these cells during the course of HIV-1 infection. Experimental evidence supports a pathophysiologic role of the apoptotic process in depletion of CD4 cells in acquired immunodeficiency syndrome (AIDS). The Fas-receptor/Fas-ligand (Fas-R/Fas-L) system mediates signals for apoptosis of susceptible lymphocytes and lympoblastoid cell lines. A number of investigators have recently reported increased expression of the Fas receptor in individuals with HIV infection, along with increased sensitivity of their lymphocytes to anti-Fas antibody mimicking Fas ligand. We attempted to determine the role of Fas-mediated apoptosis in disease progression and viral replication. Increased Fas-receptor (CD95) expression on CD4+ and CD8+ lymphocytes was found in a large group of HIV-1-infected patients compared with normal controls; individuals with a diagnosis of AIDS and a history of opportunistic infection had significantly more Fas receptor expression than did asymptomatic HIV-infected persons and normal blood donor controls (P < .01). Triggering of the Fas-R by agonistic anti-Fas monoclonal antibody, CH11, was preferentially associated with apoptosis in the CD4+ cells; this effect was more pronounced in lymphocytes derived from HIV+ individuals. Soluble and membrane-bound forms of Fas-L were produced in greater amounts in peripheral blood mononuclear cells (PBMC) cultures and in plasma obtained from HIV-1-infected persons than from normal controls. Furthermore, triggering of lymphocytes from HIV-infected persons by CH11 increased levels of interleukin-1beta converting enzyme (ICE), a protein associated with apoptosis. When PBMC were cultured in the presence of CH11, p24 production per number of viable cells was decreased as compared with the same PBMC without CH11 (P < .01). These findings suggest that multiple mechanisms, including increased production of Fas-L by infected PBMC, increased Fas-R expression, and induction of a protease of ICE family, may play roles in the apoptotic depletion of CD4+ cells in HIV infection.