gebhart/patrepeval huggingface dataset:
A Subtype-Selective Thyromimetic Designed to Bind a Mutant Thyroid Hormone Receptor Implicated in Resistance to Thyroid Hormone (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Subtype-Selective Thyromimetic Designed to Bind a Mutant Thyroid Hormone Receptor Implicated in Resistance to Thyroid HormoneHai Fen Ye, Kathryn E. O'Reill, and John T. KohView Author Information Department of Chemistry and Biochemistry University of Delaware, Newark, Delaware 19716 Cite this: J. Am. Chem. Soc. 2001, 123, 7, 1521–1522Publication Date (Web):January 30, 2001Publication History Received20 September 2000Published online30 January 2001Published inissue 1 February 2001https://pubs.acs.org/doi/10.1021/ja003442jhttps://doi.org/10.1021/ja003442jrapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views306Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Agonists,Genetics,Ligands,Receptors,Therapeutics Get e-Alerts
Purification of platinum and gold structures after electron-beam-induced deposition (2006)

The technique of electron-beam-induced deposition (EBID), when performed with organic precursors, typically results in relatively low metal content due to the partial decomposition of the organic precursor, leaving carbon-rich remnants in the deposition. Here we describe a method applied to noble-metal structures deposited using EBID, consisting of a post-treatment step of heating in a reactive atmosphere of oxygen, whereby the amount of carbon in the structure is strongly reduced. As a result, we have been able to increase the purity of platinum deposits from 15 at.% to nearly 70 at.%, and gold similarly from 8 at.% to nearly 60 at.%. The resistivity of these structures has also been improved by up to four orders of magnitude, to achieve (1.4 ± 0.2) × 104 µΩ cm in the case of platinum.
Non-scan design for testable data paths using thru operation (2002)

We present a new non-scan DFT technique for register-transfer (RT) level data paths. In the technique, we add thru operations to some operational modules to make the data path easily testable. We define a testable measure, weak testability, and consider the problem to make the data path weakly testable with minimum hardware overhead. We also define a measure to estimate the test generation time. Experimental results show the effectiveness of our technique and the proposed measure.
A cell-laden nanofiber/hydrogel composite structure with tough-soft mechanical property (2013)

Connective tissue is a factor of great importance in tissue engineering and regenerative medicine because it has a limited life but complicated mechanical properties. In this study, we present a reinforcement method of hydrogel using patterned nanofibers to mimic native connective tissues with selective engagement of load carrying constituents. We incorporated a three-dimensional nanofibrous frame fabricated using direct-write electrospinning with a hydrogel matrix. Three types of nanofiber-reinforced hydrogel composite were fabricated and their dual aspects of mechanical properties for compressive load were identified. It was demonstrated that the constructed composite had sufficient biocompatibility as well as connective tissue-like mechanical properties.
The C-shunt Flux Qubit: A New Generation of Superconducting Flux Qubit (2014)

While quantum computation has the potential to revolutionize the scientific community, to date no architecture has been developed which offers the necessary combination of high coherence times and massive scalability. Superconducting flux qubits satisfy the second requirement well but to date useful devices are limited to coherence times of typically only a few &amp;mus. In this dissertation we examine the possibilities of improving the coherence performance of the flux qubit to the levels required for fault-tolerant quantum computation. We find that coherence times for many devices are limited by photon-induced quasiparticles and mitigation of these quasiparticles increases coherence times by more than a factor of two. Beyond this, however, we find little improvement in flux qubit performance compared to prior results. Despite improved fabrication techniques and varied device designs we find flux qubit coherence times are still typically below 5 &amp;mus. Furthermore, wide device-to-device variations are observed which prevent effective scaling of the flux qubit to quantum information circuits.Based on the proposal by You, et al. we develop of a capacitively-shunted version of the flux qubit called the C-shunt flux qubit. With the addition of a capacitive shunt across the small junction of the flux qubit we are able to reduce the amplitude sensitivity to both charge and flux noise by more than a factor of three. The result is a predicted ten-fold enhancement in the coherence times compared to the unshunted flux qubit. At the same time we preserve much of the anharmonicity of the flux qubit resulting in a device with coherence times comparable to modern transmons but with a factor of four better anharmonicity and more flexible coupling configurations.By using a high-quality MBE aluminum shunt process on an annealed sapphire substrate coupled with a more conventional electron-beam-evaporated aluminum Josephson junction process we fabricate hybrid C-shunt flux qubits. We also incorporate a new bridgeless junction technique which offers more robust and repeatable fabrication processing. This technique enables improved accuracy of the junction sizing, a trait which will become essential as we move to multi-qubit experiments. T1 and T2 times for these C-shunt devices reach in excess of 40 &amp;mus at degeneracy, achieving the predicted ten-fold improvement based on the reduced noise sensitivity. At the same time we see decreased device-to-device variation with typical T1 times exceeding 20&amp;ndash25 &amp;mus at all bias points. Combined with the high anharmonicity and standard planar fabrication techniques these coherence times make the C-shunt flux qubit a competitive candidate for fault-tolerant quantum computation.
The Copyright Box Model (2017)

Intellectual property law is territorial in nature. That is why intellectual property assets have always been favorites among international tax planners. Rapid appreciation, even faster transfer times, and a somewhat vague standard for appraisal and valuation make for an interesting field of play. Transfer the assets to a low tax jurisdiction before the appreciation begins, and you find yourself with a large income stream that is taxed at a low rate. Miss the beat, and you have a large tax hit. For these reasons, many nations have followed the lead of Ireland in providing for so-called “patent box” schemes. These tax incentives provide lower tax rates for corporations who agree to develop intellectual property in the host country. With global IP royalties over $300 billion in 2014, a tax savings of a few percentage points quickly adds up. But patents are not the only IP assets that can be developed and licensed. Recently, the Dutch government realized this and expanded their “patent box” regime and renamed it the “innovation box.” While most of the world has focused on the interesting planning and development opportunities afforded patents and so-called “high-tech startups,” this Article will discuss the opportunities afforded by the lowerhanging fruit of copyrights and copyright royalties. This Article suggests that copyrights are a lower-hanging fruit, and that by providing incentives for copyright development, developing nations will spend less and reap more benefit. Part I will discuss a short history of the patent box. Part II will ask why a copyright box might be preferable. Parts III and IV will discuss criticisms of box schemes, and then look at the OECD’s BEPS project in more detail. Part V will examine what issues will govern the design and implementation of a copyright box.
Hybrid zero dynamics of planar biped walkers (2003)

Planar, underactuated, biped walkers form an important domain of applications for hybrid dynamical systems. This paper presents the design of exponentially stable walking controllers for general planar bipedal systems that have one degree-of-freedom greater than the number of available actuators. The within-step control action creates an attracting invariant set - a two-dimensional zero dynamics submanifold of the full hybrid model $whose restriction dynamics admits a scalar linear time-invariant return map. Exponentially stable periodic orbits of the zero dynamics correspond to exponentially stabilizable orbits of the full model. A convenient parameterization of the hybrid zero dynamics is imposed through the choice of a class of output functions. Parameter optimization is used to tune the hybrid zero dynamics in order to achieve closed-loop, exponentially stable walking with low energy consumption, while meeting natural kinematic and dynamic constraints. The general theory developed in the paper is illustrated on a five link walker, consisting of a torso and two legs with knees.
A discrete shear triangular nine D.O.F. element for the analysis of thick to very thin plates (1989)

Abstract This paper deals with the formulation and the evaluation of a new three node, nine d.o.f. triangular plate bending element valid for the analysis of thick to thin plates. The formulation is based on a generalization of the discrete Kirchhoff technique to include the transverse shear effects. The element, called DST (Discrete Shear Triangle), has a proper rank and is free of shear locking. It coincides with the DKT (Discrete Kirchhoff Triangle) element if the transverse shear effects are not significant. However, an incompatibility of the rotation of the normal appears due to shear effects. A detailed numerical evaluation of the characteristics and of the behaviour of the element has been performed including patch tests for thin and thick plates, convergence tests for clamped and simply supported plates under uniform loading and evaluation of stress resultants. The overall performance of the DST element is found to be very satisfactory.
Neglecting human resource development in OBOR, a case of the China–Pakistan economic corridor (CPEC) (2017)

Purpose The purpose of this paper is to obtain greater insights into the implications for human resource development (HRD) in times of economic development, with a focus on China–Pakistan economic corridor (CPEC). In recent times of economic development, a number of economic corridors have emerged globally as tools of regional cooperation and development. In the context of Pakistan, there is a lack of appropriate attention to the field of HRD, which has suffered neglect through the decades (Abbasi and Burdey, 2008; Asrar-ul-Haq, 2015). With this conception, the present economic interventions merit a well-constructed and proper HRD policy for Pakistan. This study will provide HRD insights for policymakers, researchers, entrepreneurs and business executives. Design/methodology/approach The research approach of this study is purely based on literature review and on secondary data. Findings Based on the facts and literature reviews, this study concluded that One belt, One Road in general and CPEC in particular as an economic corridor can bring sustainable and long-lasting impact on the economy only if HRD is given proper attention. Originality/value To the best knowledge of the researchers, this is the first study that highlighted the HRD issue in CPEC.
A Simple Multiplex Real-Time PCR Methodology for the <i>SMN1</i> Gene Copy Number Quantification (2009)

Spinal muscular atrophy (SMA) is an autosomal recessive disease caused, in about 95% of SMA cases, by homozygous deletion of the survival motor neuron 1 (SMN1) gene or its conversion to the highly homologous SMN2 gene. The molecular diagnosis of SMA is usually carried out by a PCR-Restriction fragment length polymorphism (RFLP) approach. However, this approach is not useful for identification of healthy deletion carriers. TaqMan technology is one of the most reliable and widely adopted techniques for the SMN1 copy number evaluation. However, several limitations of this technique have been described. Particularly, DNA extraction methods and accurate template quantification have been shown to be critical for reliable results. In this work, we set up a reliable, highly reproducible, and easy-to-perform TaqMan technology-based protocol to obtain the SMN1 gene copy number assessment. We demonstrate that PCR amplification of both target gene and reference gene in the same reaction mix, instead of separated mixes, greatly reduces reported criticisms of simplex TaqMan technology. The multiplex real-time PCR we describe allows interlaboratory samples and data exchange, without the need to equalize the DNA isolation technique. Further, the protocol described below requires fewer replica tests than the simplex methodology does, leading to reduced overall cost for the diagnostic assay.
To Taxi or Not to Taxi? - Enabling Personalised and Real-Time Transportation Decisions for Mobile Users (2012)

We demonstrate a system that monitors the taxi availability at taxi stands by mining real-time taxi trajectory data streams. The system includes a server-side trajectory data stream processing and mining program and a client-side mobile application for Android smart phones. The server program continuously monitors for each taxi stand the numbers of taxis queueing at the taxi stand, the numbers of taxis that will pass the taxi stand, as well as the traffic conditions in the area around the stand. It delivers real time taxi and traffic information to mobile users via Restful web services. The client-side location-based mobile application consumes these services to help mobile users make informed transportation choices. For example the availability of taxis might yet be a deterrent when traffic is congested. Real world taxi trajectory data from more than 14000 taxis are used in the demo.
Distinctive Medullary and Germinal Center Proliferative Patterns in Mouse Lymph Nodes after Regional Primary and Secondary Stimulation with Tetanus Toxoid (1974)

Abstract In an attempt to gain more insight into antigen-induced generation of plasma cells and memory B cells, respectively, we compared medullary proliferative responses and germinal center development in popliteal lymph nodes of young adult mice with antibody production as a function of time after primary and secondary stimulation with fluid tetanus toxoid (FTT) via the hind leg footpads. Differences in the time course of primary and secondary antibody responses correlated with the time sequence and magnitude of medullary proliferative activity rather than with germinal center formation and growth. Initial labeling indices of lymphoid and plasmocytoid cells were determined after injection of 3H-thymidine. After primary antigenic stimulation, medullary-labeling indices showed moderate oscillations with a maximum (8%) on day 6 and subsequent variations above control levels to day 32. In contrast to this limited but sustained primary proliferative response, medullary-labeling indices after booster injection of the antigen rose to a sharp, high peak (30%) on day 3 and then fell abruptly to almost control values between days 5 and 6. Germinal center activity, as expressed in both numerical increase and expansion of individual centers, was at least as important after primary stimulation as after the booster injection, although the latter evoked formation of these structures 2 to 3 days earlier than the primary stimulus. Variations in numbers and total mass of germinal centers during the anamnestic response were characterized by a maximum on day 5, followed by a rapid decline to day 6, i.e., when serum antibody titers attained a high plateau, and a second rise to day 12. This pattern differed significantly from that after primary injection of FTT showing a more sustained germinal center deployment between days 6 and 14. These observations support the view suggested previously by other authors that germinal centers are predominantly involved in the generation of memory B cells, and do not contribute markedly to antibody production elicited by the same antigen which evoked their de novo formation and expansion.
Optimized time-domain resource partitioning for enhanced inter-cell interference coordination in heterogeneous networks (2012)

Heterogeneous networks (HetNets) are expected to be one of the major performance enhancement enablers of LTE-Advanced. Due to significantly challenging interference scenarios, enhanced inter-cell interference coordination (eICIC) based on almost blank subframes (ABS) is the key technology enabler that makes HetNets a reality. The key factor determining the gain of ABS-based eICIC is the configured number of ABS which depends closely on the number of UEs requesting protection from ABS. In this paper, we study the optimal amount of ABS for synchronous ABS configuration by formulating this optimization as a network-wide utility maximization problem. We firstly propose a distributed method to determine victim UEs protected by ABS for any given amount of ABS via dynamic programming, and then find the optimal amount of ABS by evaluating the overall system utility. A remarkable feature of the proposed solution is that only limited information exchange via backhaul is required and the optimal amount of ABS could be individually derived at each eNB. Extensive simulations demonstrate that our solution can not only improve the overall system throughput significantly but also provide better network-wide fairness.
Oxygenation of aromatic compounds with diisopropyl peroxydicarbonate-cupric chloride (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygenation of aromatic compounds with diisopropyl peroxydicarbonate-cupric chloridePeter Kovacic, C. Glenn Reid, and Michael E. KurzCite this: J. Org. Chem. 1969, 34, 11, 3302–3308Publication Date (Print):November 1, 1969Publication History Published online1 May 2002Published inissue 1 November 1969https://pubs.acs.org/doi/10.1021/jo01263a017https://doi.org/10.1021/jo01263a017research-articleACS PublicationsRequest reuse permissionsArticle Views101Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Learning Personas from Dialogue with Attentive Memory Networks (2018)

The ability to infer persona from dialogue can have applications in areas ranging from computational narrative analysis to personalized dialogue generation. We introduce neural models to learn persona embeddings in a supervised character trope classification task. The models encode dialogue snippets from IMDB into representations that can capture the various categories of film characters. The bestperforming models use a multi-level attention mechanism over a set of utterances. We also utilize prior knowledge in the form of textual descriptions of the different tropes. We apply the learned embeddings to find similar characters across different movies, and cluster movies according to the distribution of the embeddings. The use of short conversational text as input, and the ability to learn from prior knowledge using memory, suggests these methods could be applied to other domains.
Mechanical Interactions in Branched or Subparallel Hydraulic Fractures (1987)

ABSTRACT A numerical simulator has been used in the study of a hydraulic fracture with two nearly parallel branches. The pressure required to propagate a branched fracture is found to be significantly higher than the pressure needed to extend a single planar fracture. Interactions with natural fractures have also been studied. The results show that hydraulic fractures may develop offsets at crosscutting natural fractures. Slip occurring on weakness planes after the hydraulic fracture crosses them has been modeled, demonstrating a reduction in fracture width at the site of the offset. This reduction in width may lead to proppant bridging at that location. An elastic calculation for the size of zones within which sliding may occur on preexisting weakness planes around a pressurized fracture indicates that the extent of these zones is proportional to the length of the pressurized fracture. Slip in such zones is controlled by the far-field stress, the pressure in the fracture, and the orientation and frictional properties of the weakness planes.
New Approach To Ensure Long-Term Zonal Isolation for Land Gas Wells Using Monobore Cemented Completion (2007)

Abstract Cemented completion provides an excellent opportunity for low cost drilling techniques and simple well designs to reduce well delivery costs without impact on safety or well integrity. In this concept, the completion is run straight into the open hole and cemented in place. There is no need to run a liner and perform a traditional cleanup. The cement effectively replaces the production packer. Achieving a good cement job is essential to a successful operation. A failed cement job would require cutting and pulling of the completion before running a conventional completion and packer, unless there was a high confidence in the outcome of a remedial cement job. Therefore good conditions for cementing are a definite requirement. Gas production and gas storage wells are particularly demanding on the cement sheaths. A failure of the sheath through de-bonding, cracking or plastic deformation results in formation fluids to enter the annulus, which pressurises the well and makes it unsafe to operate, the consequences are either losing the well altogether or, at best, an expensive intervention. Advanced cement technology combined with state of the art software are used today to ensure a complete long-term zonal isolation of the cemented completion. The software can model the stresses in a particular well over its entire life, including changes to the formation properties, well completion parameters, formation in-situ stresses, and operating envelope and can compare the properties of different available cements to enable the optimum cement to be selected (hole size, cement sheath thickness). The following paper will describe the process and the engineered cement used to ensure integrity of the cemented completion and lists case histories of the 3 cemented Completions successfully cemented Onshore Netherlands.