gebhart/patrepeval huggingface dataset:
Murine neutrophils require α1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum (2003)

Anaplasma phagocytophilum causes human granulocytic ehrlichiosis, the second most common tick-borne disease in the United States. Mice are natural reservoirs for this bacterium and man is an inadvertent host. A phagocytophilum's tropism for human neutrophils is linked to neutrophil expression of P-selectin glycoprotein ligand-1 (PSGL-1), as well as sialylated and alpha1,3-fucosylated glycans. To determine whether A phagocytophilum uses similar molecular features to infect murine neutrophils, we assessed in vitro bacterial binding to neutrophils from and infection burden in wild-type mice; mice lacking alpha 1,3-fucosyltransferases Fuc-TIV and Fuc-TVII; or mice lacking PSGL-1. Binding to Fuc-TIV-/-/Fuc-TVII-/- neutrophils and infection of Fuc-TIV-/-/Fuc-TVII-/- mice were significantly reduced relative to wild-type mice. A phagocytophilum binding to PSGL-1-/- neutrophils was modestly reduced, whereas sialidase treatment significantly decreased binding to both wild-type and PSGL-1-/- neutrophils. A phagocytophilum similarly infected PSGL-1-/- and wild-type mice in vivo. A phagocytophilum induced comparable levels of chemokines from wild-type and PSGL-1-/- neutrophils in vitro, while those induced from Fuc-TIV-/-/Fuc-TVII-/- neutrophils were appreciably reduced. Therefore, A phagocytophilum infection in mice, as in humans, requires sialylation and alpha1,3-fucosylation of neutrophils. However, murine infection does not require neutrophil PSGL-1 expression, which has important implications for understanding how A phagocytophilum binds and infects neutrophils.
Analysis of multi‐port amplifier calibration for optimal magnitude and phase error detection (2015)

This study presents theoretical analysis and verification on optimal hardware platform for calibration of signal manipulation in multi‐port amplifier (MPA). Since MPA output power and isolation characteristics are strongly dependent on magnitude and relative phase balances in each array path of MPA, proper calibration technique is necessary for ideal MPA operation. Although variety of calibration methods can be considered, they can be classified into two methods from the calibration signal detection based on hardware platform point of view. That is, calibration signals for each array path in MPA can be sampled and detected before output hybrid matrix (OHM) or after OHM according to hardware setup. Since optimal signal detection for each array path is the key to ideal MPA calibration and maximised performance, this study theoretically analyses two different calibration hardware platforms detecting calibration signals. Then, the mathematically derived optimal calibration hardware setup for detecting magnitude and phase error is finally verified and concluded by simple simulation and measurement at 900 MHz Industrial, Scientific and Medical‐band (902–928 MHz).
Identity-based encryption based on DHIES (2010)

Most traditional public key cryptosystems are constructed upon algebraically rich structures, which makes their key pairs combinable, i.e., the combination of some private keys and their corresponding public keys could form a new key pair. Exploring such combinable property, this paper proposes a novel Identity-Based Encryption (IBE) scheme based on the Diffie-Hellman Integrated Encryption Scheme (DHIES) with quadratic key combination structure from bilinear maps. The new scheme has a number of advantages over other IBE schemes. First, it uses DHIES to fulfill encryption, thus naturally obtains the security against adaptive chosen ciphertext attack from DHIES. Second, it is interoperable with existing security systems based on DHIES. Third, compared to many pairing-based IBE schemes, it only requires pairing computation during public key generation and there is no need for special hash function. We prove that our scheme is selective identity chosen ciphertext secure in the random oracle model assuming DHIES is chosen ciphertext secure. Additionally, the extract algorithm of our scheme also implies an identity-based short signature scheme.
Regulation of the angiopoietin-like protein 3 gene by LXR (2003)

Angiopoietins are members of the vascular endothelial growth factor family. One family member, angiopoietin-like protein 3 (Angptl3), was recently shown to be predominantly expressed in the liver and to play an important role in regulating lipid metabolism. In this study, we show that the Angptl3 gene is a direct target of the liver X receptor (LXR). Mice fed a high cholesterol diet exhibited a significant increase in Angptl3 expression in the liver. Oral administration to mice of T0901317, a synthetic LXR-selective agonist, increases levels of plasma lipids and Angptl3 mRNA in the liver. Treatment of HepG2 cells with LXR selective agonists led to a dose-dependent increase of Angptl3 mRNA. Analysis of the DNA sequence just 5' of the Angptl3 transcriptional start site revealed the presence of several potential transcription factor binding sites, including that for LXR. When transfected into HepG2 cells, the promoter activity of Angptl3 was significantly induced by LXR- or retinoid X receptor-selective agonists. Mutation of the predicted LXR binding site (DR4 element) completely abolished the LXR agonist-mediated activation of the promoter. Together, these studies show that Angptl3 is transcriptionally regulated by LXR, and reveals a novel mechanism by which LXR may regulate lipid metabolism.
Beta-Expansion: A Theoretical Framework for Fast and Recursive Construction of Polar Codes (2017)

In this work, we introduce β-expansion, a notion borrowed from number theory, as a theoretical framework to study fast construction of polar codes based on a recursive structure of universal partial order (UPO) and polarization weight (PW) algorithm. We show that polar codes can be recursively constructed from UPO by continuously solving several polynomial equations at each recursive step. From these polynomial equations, we can extract an interval for β, such that ranking the synthetic channels through a closed- form β-expansion preserves the property of nested frozen sets, which is a desired feature for low- complex construction. In an example of AWGN channels, we show that this interval for β converges to a constant close to 1.1892 when the code block-length trends to infinity. Both asymptotic analysis and simulation results validate our theoretical claims.
In Reference to <i>Anosmia and Ageusia: Common Findings in COVID‐19 Patients</i> (2020)

We read with interest the article "Anosmia and Ageusia: Common Findings in COVID-19 Patients" by Vaira et al. proposing that anosmia and ageusia may be early symptoms in 19.4% of COVID-19 patients. In comparison with China, olfactory and gustatory dysfunction was more prevalent in Europe. Lechien et al. reported that Italy and Germany had shown a higher prevalence of olfactory dysfunction (23.8% and 79.7%, respectively) and gustatory dysfunction (28.9% and 88.8%, respectively), 2 whereas Mao et al. reported only 5.1% olfactory dysfunction and 5.6% gustatory dysfunction. The differences between populations are quite distinct. Currently, the possible mechanism of olfactory and gustatory dysfunction due to COVID-19 infection remains to be elucidated, and several possible pathophysiological mechanisms are suggested.
DNA Hybridization Assay for Detection of Salmonella in Foods: Collaborative Study (1987)

A collaborative study was performed in 11 laboratories to validate a DNA hybridization (DNAH) procedure for detection of Salmonella in foods. The DNAH procedure was compared to the standard culture method for detection of Salmonella in 6 foods: ground pepper, soy flour, dry whole egg, milk chocolate, nonfat dry milk, and raw deboned turkey. With the exception of turkey which was naturally contaminated, uninoculated and inoculated samples of each food group were analyzed. Results for the DNAH method were significantly better than for the standard culture method at the 5% probability level for the detection of Salmonella in turkey. There was no significant difference between the methods for the other 5 foods. The method has been adopted official first action.
Solution Rheology of Hyperbranched Polyesters and Their Blends with Linear Polymers (2000)

The rheological properties of different generations of hyperbranched polyesters in 1-methyl-2-pyrrolidinone solvent and their blends with a poly(2-hydroxyethyl methacrylate) are examined in this study. All the hyperbranched polyester solutions exhibit Newtonian behavior, with steady shear viscosities independent of shear rate. This indicates the absence of physical entanglements in these systems. In addition, solution viscosities are found to be only slightly affected by the different generations of the hyperbranched polymer. The polyesters have very small intrinsic viscosities, and their hydrodynamic radius scales as Rh ∼ M0.39, suggesting a less packed structure than dendrimers. All generations of the hyperbranched polyesters also show comparable apparent activation energies of flow over the temperature range studied. Replacing linear polymers with hyperbranched polymers causes large reductions in the blend viscosities. This behavior can be attributed to the decrease in both the number of physical entanglements between linear polymers and the blend's intrinsic viscosity upon addition of the hyperbranched polymer.
THE EFFECT OF FREQUENCY OF ROTATIONAL BURNING ON BLUEBERRY PRODUCTION (1963)

The results of a 9-year rotational burning study on blueberry fields at the Experimental Project Farm, Alliston, Prince Edward Island, indicated that total fruit production was greater from burning every second year than from every third year. Both burning treatments produced large yield increases over the unburned areas and injury from the blueberry maggot was largely controlled.Within the scope of this study, there was no evidence that flash burning, at either 2- or 3-year intervals, had seriously affected the rhizomes or the reserves of plant food in the soil.
RFID-Based Locating Management (2008)

After manufacturing and retail marketing, locating management is considered to be the next home for radio frequency identification (RFID). RFID technology has gained a great potential in locating management to achieve the flexibility, maintainability and extensibility of the system. However, the challenge will be to incorporate RFID into locating management, especially when relevant experience is limited. The RFID-based locating management system must be deployed quickly according to the requirements of the different applications and generate location data fast and efficiently. The paper investigates the issues related to effective RFID dynamical deployment and RFID data management, and introduces an appropriate architecture for dealing with the problems described above.
Historical review of microbend fiber-optic sensors (1995)

This paper traces microbend sensors from the early investigative work into initial applications to measure many different parameters, through advanced prototype development and commercial hardware. Advantages and disadvantages of microbend sensors are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Novel and Ultrasensitive Sandwich Enzyme Immunoassay (Sandwich Transfer Enzyme Immunoassay) for Antigens (1988)

Abstract A novel and ultrasensitive sandwich enzyme immunoassay (sandwich transfer enzyme immunoassay) for antigens is described. Antigens were reacted with dinitrophenyl monoclonal mouse antibody IgG1 and rabbit antibody Fab′-ß-D-galactosidase conjugates. The complex formed of antigens with dinitrophenyl monoclonal mouse antibody IgG1 and rabbit antibody Fab′-ß-D-galactosidase conjugates was trapped onto affinity-purified rabbit (antidinitrophenyl bovine serum a1bumin) IgG-coated polystyrene balls. After eliminating excess of the conjugates, the complex was eluted from the polystyrene balls with dinitrophenyl-L-lysine and transfered to clean polystyrene balls coated with affinity-purified rabbit (anti-mouse IgG) IgG. ß-D-Galactosidase activity bound to the (anti-mouse IgG) IgG-coated polystyrene balls was assayed by fluorimetry. Nonspecifically bound ß-D-galactosidase activity considerably decreased with less decrease in specifically bound ß-D-galactosidase activity. As a result, the detection limits of human thyroid-stimulating hormone (0.01 nu, 0.02 amol) and human growth hormone (10 fg, 0.5 amol) by the present enzyme immunoassay were 30-fold lower than those by the conventional enzyme immunoassay, in which antigens were incubated with monoclonal mouse antibody IgG1-coated polystyrene balls and rabbit antibody Fab′-ß-D-galactosidase conjugates.
Printer forensics based on page document's geometric distortion (2009)

A printed document can provide intrinsic features of the printer so as to distinguish which printer it comes from. But how to extract the intrinsic features is critical in printer forensics. In this paper, the page document's geometric distortion is extracted as the intrinsic features, and a printer forensics method based on the distortion is proposed. Firstly projective transformation model is used to model the geometric distortion. After the feature point set of the model is extracted, the model's parameters considered as the geometric distortion features can be estimated, and then the model's error pattern can be obtained. During the process, the least squares method is used to estimate the model's parameters, and SVM technique is used for classification. The effectiveness of the model's parameters in the printer forensics is demonstrated by experimental results.
Minimal cells: Relevance and interplay of physical and biochemical factors (2011)

Research on the construction of minimal cell-like systems is continuously progressing. The aim is to assemble a synthetic or semi-synthetic cell by encapsulating the minimal set of different macromolecules into a lipid vesicle (liposome). Synthetic cells have their relevance as new biotechnological tool for use in synthetic biology and in research into the origin of life. In recent years, several technical advances have been reported and reviewed, but most deal with the biochemical and molecular biology of protein synthesis inside liposomes, whereas a discussion on the importance and the interplay of some physical factors has not been discussed. In this short review, we comment on physical aspects, such as compartment formation and solute entrapment, and on the nature of lipid membrane. Emphasis is given to their relevance for the technology of construction of synthetic cells, and for new aspects of vesicle population studies.
Characterization of novel amino acid fucosides. (1981)

The structures of FL4b and of two other related amino acid fucosides have been determined by a combination of methylation analysis and enzymatic digestion. Additionally, the anomeric configurations of the carbohydrate moieties of FL4a, previously shown to be glucosyl(1 leads to 3)fucosyl 1 leads to threonine (Steiner, S., Via, D. P., Klinger, M., Larriba, G., Sramek, S., and Laine, R. (1978) in Glycoproteins and Glycolipids in Disease Processes (Walborg, E. F., Jr., ed) pp. 378-403, American Chemical Society, Washington, D. C.) have been determined by enzymatic digestion. The results indicate that the structures are: FL3a, fucosyl alpha 1 leads to threonine; FL3b, fucosyl alpha 1 leads to serine; FL4a, glucosyl beta 1 leads to 3 fucosyl alpha 1 leads to threonine; and FL4b, glucosyl beta 1 leads to 3 fucosyl alpha 1 leads to serine. FL4a, which appears to have the same structure as a component from human urine (Hallgren, P., Lundblad, A., and Svensson, S. (1975) J. Bil. Chem. 250, 5312-5314), and FL4b are highly unusual in that they contain fucose in a nonterminal position. The fucosyl-serine linkage found in compounds FL3b and FL4b is a novel structure.
Thyroid Hormone Increases mRNA and Protein Expression of Na+-K+-ATPase α2 and β1 Subunits in Human Skeletal Muscles (2006)

This provides the first evidence that, in human skeletal muscles, thyroid hormone up-regulates the Na+-K+-ATPase protein expression at least, in part, at mRNA level, and the alpha2 and beta1 subunits play the important role in this regulation.
Chemical oxidation of chlorinated organics by hydrogen peroxide in the presence of sand (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical oxidation of chlorinated organics by hydrogen peroxide in the presence of sandJoseph X. Ravikumar and Mirat D. GurolCite this: Environ. Sci. Technol. 1994, 28, 3, 394–400Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/es00052a009https://doi.org/10.1021/es00052a009research-articleACS PublicationsRequest reuse permissionsArticle Views940Altmetric-Citations171LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Algorithm for Construction of Test Cases for the Quadratic Assignment Problem (2000)

In this paper we present an algorithm for generating quadratic assignment problem (QAP) instances with known provably optimal solution. The flow matrix of such instances is constructed from the matrices corresponding to special graphs whose size may reach the dimension of the problem. In this respect, the algorithm generalizes some existing algorithms based on the iterative selection of triangles only. The set of instances which can be produced by the algorithm is NP-hard. Using multi-start descent heuristic for the QAP, we compare experimentally such test cases against those created by several existing generators and against Nugent-type problems from the QAPLIB as well.
Evolutionary building layout optimisation (2011)

A Doctoral Thesis. Submitted in partial fulfillment of the requirements for the award of Doctor of Philosophy of Loughborough University.
Topographic analysis of K-ras mutations in histologically normal lung tissues and tumours of lung cancer patients (2001)

Mutations in the K- ras gene are very common in lung tumours and are implicated in the development of lung cancer, but the timing of their occurrence remains poorly understood. We investigated K- ras mutations in cell samples microdissected by laser capture microscopy at multiple sites from lung tissue sections representing tumour tissue and matched histologically normal tissue obtained from 48 lung cancer patients. K- ras mutations were detected in cell samples from 10 of 38 (26.3%) lung adenocarcinomas and in none of the histologically normal or tumour cell samples taken from 10 lung squamous cell carcinomas. Of the K- ras mutation-positive adenocarcinomas, in 4 cases a mutation was found in only the tumour tissue, in 1 case a mutation was found only in the histologically normal tissue, and in 5 cases mutations were found in both the tumour tissue and histologically normal tissue. Among these 5 cases, 2 had identical mutations in both the tumour tissue and histologically normal tissue, 2 had 1 mutation in the tumour tissue and 2 mutations in the histologically normal tissue, 1 of which was identical to the mutation found in the tumour, and 1 case had 2 codon 12 mutations in tumour tissue and 2 mutations, in codons 9 and 11, in histologically normal tissue. These results showed that K- ras mutations are frequent in histologically normal cells taken from outside lung adenocarcinomas and suggest that some of these mutations may represent early events which could pave the way of lung carcinogenesis.
Facile synthesis of mesoporous MOF/silica composites (2014)

HKUST-1 MOF/silica composites with narrow mesopore size distribution were prepared by facile hydrothermal synthesis in the presence of cetyltrimethylammonium bromide (CTAB).
An analysis of fatal and non-fatal head wounds incurred during combat in Vietnam by U.S. forces. (1982)

Analysis of data obtained from U.S. military personnel who received either a lethal or non-lethal brain or head wound in Vietnam indicate that: 1. Bullets caused more fatal brain wounds that did fragments. 2. Most bullet wounds were received at close range, 40.9 m average. Most fatal fragment wounds to the brain occurred at a very close range, 2.9 m average. 3. Clinically significant intracranial blood clots occurred in only 7% of all fatal brain wounds. Only one man with a non fatal brain wound had an associated clot, 3.3%. 4. Helmets offered no protection against bullets but gave significant protection against fragments. 5. Men who sustained either fetal or non fatal brain wounds became immediately militarily non effective.
cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis (1996)

By using a combination of the methods of reverse transcription-PCR and rapid amplification of cDNA ends, a cDNA for rat pS2 peptide (rpS2) was successfully cloned and sequenced from rat stomach. By RNA blot analysis, the gene was shown to be expressed abundantly in the stomach and only faintly in the duodenum, but not in other tissues including the distal small and large intestines. rpS2 expression was also examined in the rectum during the course of acetic acid-induced colitis; rpS2 mRNA was detected during the acute phase of colitis but not in normal controls or during the recovery phase. On the other hand, expression of rat intestinal trefoil factor (rITF) was down-regulated during the acute phase of colitis and then up-regulated during the recovery phase, whereas rat spasmolytic peptide was not detectable throughout the course of the induced colitis. These results indicate that the patterns and timing of the expression of these trefoil peptides are different from each other. rpS2 may play an important role in the proliferation of intestinal epithelial cells during the acute phase of mucosal ulceration, whereas rITF may be involved in differentiation of the cells, particularly to form goblet cells, during the recovery phase.
Treatment of children with refractory acute lymphocytic leukemia with vincristine and diltiazem (1985)

Six children with refractory acute lymphocytic leukemia were treated with vincristine combined with diltiazem. In four of five children who took the drug as scheduled, a cytolytic effect was observed. One child showed massive cell destruction which caused hyperuricemic nephropathy. The only adverse effect was atrioventricular block in two children, which was completely reversible. Increased neurotoxicity was not observed in any child.