gebhart/patrepeval huggingface dataset:
Luminescent organometallic complexes as visible probes in the isothermal curing of epoxy resins (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLuminescent organometallic complexes as visible probes in the isothermal curing of epoxy resinsThomas G. Kotch, Alistair J. Lees, Stephen J. Fuerniss, and Kostas I. PapathomasCite this: Chem. Mater. 1992, 4, 3, 675–683Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/cm00021a033https://doi.org/10.1021/cm00021a033research-articleACS PublicationsRequest reuse permissionsArticle Views211Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rationally engineered polymeric cisplatin nanoparticles for improved antitumor efficacy (2011)

The use of cisplatin, a first line chemotherapy for most cancers, is dose-limited due to nephrotoxicity. While this toxicity can be addressed through nanotechnology, previous attempts at engineering cisplatin nanoparticles have been limited by the impact on the potency of cisplatin. Here we report the rational engineering of a novel cisplatin nanoparticle by harnessing a novel polyethylene glycol-functionalized poly-isobutylene-maleic acid (PEG-PIMA) copolymer, which can complex with cis-platinum (II) through a monocarboxylato and a coordinate bond. We show that this complex self-assembles into a nanoparticle, and exhibits an IC(50) = 0.77 ± 0.11 µM comparable to that of free cisplatin (IC(50) = 0.44 ± 0.09 µM). The nanoparticles are internalized into the endolysosomal compartment of cancer cells, and release cisplatin in a pH-dependent manner. Furthermore, the nanoparticles exhibit significantly improved antitumor efficacy in a 4T1 breast cancer model in vivo, with limited nephrotoxicity, which can be explained by preferential biodistribution in the tumor with reduced kidney concentrations. Our results suggest that the PEG-PIMA-cisplatin nanoparticle can emerge as an attractive solution to the challenges in cisplatin chemotherapy.
Multiple contrast metrics from the measurements of a digital confocal microscope (2013)

We describe various methods to process the data collected with a digital confocal microscope (DCM) in order to get more information than what we could get from a conventional confocal system. Different metrics can be extracted from the data collected with the DCM in order to produce images that reveal different features of the sample. The integrated phase of the scattered field allows for the three-dimensional reconstruction of the refractive index distribution. In a similar way, the integration of the field intensity yields the absorption coefficient distribution. The deflection of the digitally reconstructed focus reveals the sample-induced aberrations and the RMS width of the focus gives an indication on the local scattering coefficient. Finally, in addition to the conventional confocal metric, which consists in integrating the intensity within the pinhole, the DCM allows for the measurement of the phase within the pinhole. This metrics is close to the whole-field integrated phase and thus gives a qualitative image of the refractive index distribution.
Electrosynthesis of Organic Compounds from Carbon Dioxide Is Catalyzed by a Diversity of Acetogenic Microorganisms (2011)

Microbial electrosynthesis, a process in which microorganisms use electrons derived from electrodes to reduce carbon dioxide to multicarbon, extracellular organic compounds, is a potential strategy for capturing electrical energy in carbon-carbon bonds of readily stored and easily distributed products, such as transportation fuels. To date, only one organism, the acetogen Sporomusa ovata, has been shown to be capable of electrosynthesis. The purpose of this study was to determine if a wider range of microorganisms is capable of this process. Several other acetogenic bacteria, including two other Sporomusa species, Clostridium ljungdahlii, Clostridium aceticum, and Moorella thermoacetica, consumed current with the production of organic acids. In general acetate was the primary product, but 2-oxobutyrate and formate also were formed, with 2-oxobutyrate being the predominant identified product of electrosynthesis by C. aceticum. S. sphaeroides, C. ljungdahlii, and M. thermoacetica had high (>80%) efficiencies of electrons consumed and recovered in identified products. The acetogen Acetobacterium woodii was unable to consume current. These results expand the known range of microorganisms capable of electrosynthesis, providing multiple options for the further optimization of this process.
Pentaborane(9)-catalysed condensation of silylamines (1971)

W. M. Scantlin and A. D. Norman, J. Chem. Soc. D, 1971, 1246 DOI: 10.1039/C29710001246
Multimerization of anti‐(epidermal growth factor receptor) IgG fragments induces an antitumor effect: the case for humanized 528 scFv multimers (2013)

The construction of antibody fragments has the potential to reduce the high cost of therapeutic antibody production, but the structures of these fragments, with monovalency and the lack of an Fc region, can lead to reduced function. Multimerization is one strategy for recovering function that also yields better tumor-to-blood ratios than IgGs or monomeric antibody fragments because of rapid tumor uptake and clearance. Here, we constructed single-chain variable fragment (scFv) multimers by modifying the linker length and domain order of humanized anti-(epidermal growth factor receptor) IgG 528 (h528) and tested their ability to inhibit tumor growth. h528 scFv multimers, expressed using a bacterial expression system, were successfully fractionated and inhibited cancer growth in a multimerization-dependent manner, whereas the h528 scFv monomer showed no inhibition. h528 scFv trimers with variable heavy-light domain order and no linkers showed the highest in vitro and in vivo antitumor effects, which were comparable with those of the approved anti-(epidermal growth factor receptor) therapeutic IgG Cetuximab and Panitumumab. The trimers were also structurally stable in vitro and in vivo, which may be attributable to a strong interaction between the variable heavy and variable light domains of h528 Fv. Thus, h528 scFv multimers, especially trimers, are attractive as the next generation of anti-(epidermal growth factor receptor) therapeutic IgG and offer the possibility of low-cost production.
Development of improved-durability plasma sprayed ceramic coatings for gas turbine engines (1980)

As part of a NASA program to reduce fuel consumption of current commercial aircraft engines, methods were investigated for improving the durability of plasma sprayed ceramic coatings for use on vane platforms in the JT9D turbofan engine. Increased durability concepts under evaluation include use of improved strain tolerant microstructures and control of the substrate temperature during coating application. Initial burner rig tests conducted at temperatures of 1010 C (1850 F) indicate that improvements in cyclic life greater than 20:1 over previous ceramic coating systems were achieved. Three plasma sprayed coating systems applied to first stage vane platforms in the high pressure turbine were subjected to a 100-cycle JT9D engine endurance test with only minor damage occurring to the coatings.
<i>N</i>‐benzhydryl quinuclidine compounds are a potent and Src kinase‐independent inhibitor of NALCN channels (2020)

These findings suggest that N-benzhydryl quinuclidine compounds have a pharmacological potential to directly inhibit NALCN channels and could be a useful tool to investigate functions of NALCN channels.
Improved delayed enhanced myocardial imaging with T<sub>2</sub>‐Prep inversion recovery magnetization preparation (2008)

Our preliminary patient studies confirm that this preparation is helpful for improved delineation of subendocardial infarction.
Compared Reactivity of 3-, 5-, 6-, and 8-Aminoimidazo[1,2-a]pyridines in Combes Reaction: Access to Imidazonaphthyridines and Dipyrido[1,2-a:3',2'-d]imidazole (1994)

The synthesis of imidazo[l,2-a][l,8]naphthyridines and dipyrido[l,2-a:3',2'-aimidazole by treatment of aminoimidazo[l,2alpyridines following the Comhes procedure is described.The Combes procedure is a usefull synthetic method for the construction of heterocyclic compounds, particullary used for the preparation of 1,8-naphthyridines from 2-aminopyridines.' Extension of this procedure to varied amino-heterocycles is of an interest for facile construction of polycondensed heterocyclicIn continuation of our studies on the reactivity of the imidazo[l,2-alpyridine ring system, we'investigated a new approach, based on the Combes procedure, for the synthesis of imidazonaphthyridines and dipyridoimidazoles.Synthesis of starting materials (1-5) was achieved according to the published methods for compound (I),' (2a),3 (2b),4 (3),5 (4a),6 ( k , 5c).7 Ethyl 5-methyl-6-nitroimidazo[l,Z-alpyridine-2mboxylate (4b) was obtained by treatment of 6-amino-3-nitro-2-picolinea with ethyl hromopyruvate in
Fuzzy logic application for intelligent control of a variable speed drive (1994)

The slip power recovery configuration is an attractive scheme of variable speed drive, with high efficiency and low power converter rating; however, high performance control has been difficult. In this paper, novel applications of fuzzy logic for the intelligent control of a slip power recovery system are presented. A direct fuzzy logic controller and an adaptive fuzzy controller, based on model reference adaptive control, are developed and simulated for the doubly-excited induction machine and power converter system. Compared with field orientation control, the intelligent control of a complex slip power recovery system reduces costs and enhances robust and desired performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
New combination treatments in the management of diabetes: focus on sitagliptin &ndash; metformin (2008)

Type 2 diabetes mellitus is an increasingly prevalent condition worldwide. The complications of this disease are known to significantly increase the morbidity and mortality of those affected, resulting in substantial direct and indirect costs. Although good glycemic control has been shown to reduce the incidence and progression of diabetes-related microvascular complications, blood glucose levels are not adequately controlled in most individuals with diabetes. The reasons for this are many, and include issues such as poor adherence to complex medication regimes; costs of prescribed therapies; and the failure of traditionally prescribed medications to preserve beta cell function over time. However, our armamentarium of glucose-lowering drugs has expanded recently with the development of medications that act via the incretin pathway. Sitagliptin, the first commercially available dipeptidyl peptidase-4 inhibitor, inhibits the metabolism and inactivation of the incretin hormones GLP-1 and GIP. The subsequent elevation in levels of these hormones and associated prolongation of their actions has been shown to increase insulin secretion and suppress glucagon secretion in a glucose-appropriate fashion. Sitagliptin therapy in individuals with type 2 diabetes has been found to lower significantly hemoglobin A1c (Hb1c) levels with a minimum of adverse side effects such as weight gain or hypoglycemia. Use of sitagliptin in conjunction with the insulin-sensitizing medication metformin has been shown to decrease HbAlc levels more significantly than does either drug alone. This combination of medications is generally well tolerated, with no adverse effects on weight and a very low likelihood of treatment-related hypoglycemia. Use of both drugs will positively affect many of the underlying metabolic abnormalities associated with type 2 diabetes, including the disordered secretion of insulin and glucagon as well as impaired sensitivity to insulin which are known to accompany this disease. Animal studies also suggest that dipeptidyl peptidase-4 inhibitor treatment may help to preserve beta cell mass; however, it is unclear at present whether or not this will prove to be the case in humans.
Growth of hexagonal GaN thin films on Si(1 1 1) with cubic SiC buffer layers (1998)

The growth of GaN films on silicon or sapphire substrates has not been straightforward due to their large mismatch (>13%). SiC is structurally the closest material to GaN (especially cubic form) and has a small lattice mismatch (3.5%) between SiC and GaN, and therefore can be useful as the substrate for GaN. Single-crystal wafers of cubic SiC and GaN, however, are hard to obtain and have not been produced commercially yet. Therefore, a thin layer of cubic SiC on substrates such as Si and oxide single crystals might solve this problem and will be one of a suitable buffer layers for the cubic GaN film growth. Epitaxial cubic SiC buffer layers were grown on either carbonized or uncarbonized Si(1 1 1) substrates as low as temperature of 830°C using a supersonic molecular jet of t-butyldimethylsilane, (CH3)3CSiH(CH3)2, and the polycrystalline hexagonal GaN thin films were subsequently deposited on them at 600°C using a MOMBE system. The buffer layers and the GaN films were characterized by AES, XRD, FTIR, ellipsometry, and X-ray phi(φ)-scan measurements. The growth temperature of t-butyldimethylsilane was much lower than conventional CVD growth temperatures and this is the first report to obtain epitaxial cubic SiC films on Si from t-butyldimethylsilane and new attempt to grow h-GaN thin films on cubic SiC buffer layers.
A fast DS/CDMA acquisition scheme based on igniter sequence and distributed samples (2002)

This paper introduces a new acquisition scheme called distributed sample acquisition (DSA), which is applicable to the DS/CDMA system with a long-period PN sequence. The DSA scheme employs two new concepts, igniter sequence and distributed samples, for signal acquisition. The igniter sequence is a short-period sequence that conveys the main-sequence samples of the transmitter to receiver in a distributed manner, which are thus called distributed samples. In synchronizing the igniter sequence, we employ normal serial search schemes, but for synchronization of the main long-period PN sequence we employ the novel distributed sample scrambling (DSS) technique. The resulting mean acquisition time of the DSA scheme is dramatically reduced for the long period PN sequence, and the additional circuit complexity for its implementation is very small.
Polarization-based oxygen sensor (1999)

A new approach to oxygen sensing based on the luminescence polarization observed from a novel type of sensor is described. The oxygen sensor consists of an oxygen-sensitive silicone film containing tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) chloride [Ru(dpp)3Cl2] and an oxygen-insensitive film of Styryl 7 in poly(vinyl alcohol). Polarizers are used to select orthogonally polarized emission components from Ru(dpp)3Cl2 and Styryl 7. The polarization of the combined emission was found to be highly sensitive to the partial pressure of oxygen. This method of polarization sensing is generic and can be used with any fluorophore which displays an analyte-dependent change in intensity.
Problems of writing on digital surfaces in online handwriting recognition systems (2013)

Nowadays, keyboards and mice are the basic input devices for personal computers. Nevertheless, these devices may not remain as the only way of transmitting electronic data to computers. Other methods may become necessary, particularly with regard to the size of newer mobile devices and the method of transmission. Hand-held computers, mobile technology, for example, present significant opportunities for alternative devices that work in forms smaller than the traditional keyboard and mouse. In addition, the need for more natural human-machine interfaces becomes more important due to computer usage reaches a larger number of people worldwide. However, these new ways of human-machine interfaces have some problems while connecting to the computers. This paper presents and highlights some of these problems in the field of script recognition. This paper also illustrates the used techniques to overcome these matters.
A review of conventional and modern single-point sheet metal forming methods (2003)

The use of computers in manufacturing has enabled the development of several new metal forming processes that are based upon older technologies. In this case modifications have been made to traditional forming methods such as conventional spinning and shear forming. These two processes are similar in that the deformation mechanism is localized to a small region under the forming tool. Recent advances in computing power have enabled this localized deformation to be accurately controlled and studied. Spinning, shear forming and flow forming are limited to forming parts that are symmetrical about the revolving lathe axis. Current research has been focused on forming non-symmetrical parts using computer numerical control (CNC) technology, without the need for costly dies. A comparison of traditional and modern forming methods is presented here in an attempt to illustrate the evolution of different incremental sheet metal forming techniques. Emphasis is placed on conventional spinning, shear forming and modern computer-controlled forming methods that are currently being studied.
Ontology based classification for multi-label image annotation (2014)

Image annotation has been an important task for visual information retrieval. It usually involves a multi-class multi-label classification problem. To solve this problem, many researches have been conducted during last two decades, although most of the proposed methods rely on the training data with the ground truth. To prepare such a ground truth is an expensive and laborious task that cannot be easily scaled, and “semantic gaps” between low-level visual features and high-level semantics still remain. In this paper, we propose a novel approach, ontology based supervised learning for multi-label image annotation, where classifiers' training is conducted using easily gathered Web data. Moreover, it takes advantage of both low-level visual features and high-level semantic information of given images. Experimental results using 0.507 million Web images database show effectiveness of the proposed framework over existing method.
High Mobility Ratio Water Flood Performance Prediction: Challenges and New Insights (2005)

Abstract This paper presents results of a comprehensive study to improve our understanding of High Mobility Ratio Water Flood (HMRWF) and to improve its performance prediction. Published data on heavy oil water injection field projects are limited. Several successful HMRWF projects have been reported, and they show significant oil recovery at high water cut. However, the range of reported recovery is large – waterflood recoveries of ~ 1-2% to 20% OOIP have been reported for similar reservoirs. Higher viscosities result in lower recovery Mechanistic study using fine-scale simulations show that viscosity (or mobility) ratio primarily controls oil recovery response, and that the recovery is lower at higher viscosity ratios. Further, viscous fingers dominate high viscosity ratio floods, and mobile water can significantly reduce recovery. Field-scale simulation results indicate that heterogeneity plays a more important role for a HMRWF (than conventional waterfloods). The amount of primary production prior to the start of the waterflood has a larger effect on incremental oil recovery for high mobility ratio floods. Further, highly-correlated, thin, thief zones reduce recovery of HMRWF more severely, and rock wettability (relative permeabilties) strongly influences oil recovery. These results indicate that accurate viscosity and relative permeability measurements are essential for a reliable performance prediction.
Ontology-based metadata (1998)

Article Ontology-based metadata: transforming the MARC legacy Share on Author: Peter C. Weinstein University of Michigan Digital Library, Artificial Intelligence Laboratories, 1101 Beal Ave., Ann Arbor, MI University of Michigan Digital Library, Artificial Intelligence Laboratories, 1101 Beal Ave., Ann Arbor, MIView Profile Authors Info & Claims DL '98: Proceedings of the third ACM conference on Digital librariesMay 1998 Pages 254–263https://doi.org/10.1145/276675.276706Online:11 May 1998Publication History 22citation1,089DownloadsMetricsTotal Citations22Total Downloads1,089Last 12 Months11Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Three-dimensional structure of tropism-switching <i>Bordetella</i> bacteriophage (2010)

Bacteriophage BPP-1, which infects Bordetella species, can switch its specificity by mutations to the ligand-binding surface of its major tropism-determinant protein, Mtd. This targeted mutagenesis results from the activity of a phage-encoded diversity-generating retroelement. Purified Mtd binds its receptor with low affinity, yet BPP-1 binding and infection of Bordettella cells are efficient because of high-avidity binding between phage-associated Mtd and its receptor. Here, using an integrative approach of three-dimensional (3D) structural analyses of the entire phage by cryo-electron tomography and single-prticle cryo-electron microscopy, we provide direct localization of Mtd in the phage and the structural basis of the high-avidity binding of the BPP-1 phage. Our structure shows that each BPP-1 particle has a T = 7 icosahedral head and an unusual tail apparatus consisting of a short central tail "hub," six short tail spikes, and six extended tail fibers. Subtomographic averaging of the tail fiber maps revealed a two-lobed globular structure at the distal end of each long tail fiber. Tomographic reconstructions of immuno-gold-labeled BPP-1 directly localized Mtd to these globular structures. Finally, our icosahedral reconstruction of the BPP-1 head at 7A resolution reveals an HK97-like major capsid protein stabilized by a smaller cementing protein. Our structure represents a unique bacteriophage reconstruction with its tail fibers and ligand-binding domains shown in relation to its tail apparatus. The localization of Mtd at the distal ends of the six tail fibers explains the high avidity binding of Mtd molecules to cell surfaces for initiation of infection.
Effects of limited access dressing in chronic wounds: A biochemical and histological study (2015)

In the present study, we have found beneficial effect of newer intermittent negative pressure therapy in combination with moist environment (LAD) on chronic wound healing by increasing collagen deposition and angiogenesis; and reducing oxidative stress and inflammatory infiltrate.