gebhart/patrepeval huggingface dataset:
Análise da necessidade de revisão do plano ambiental da Usina Hidrelétrica Governador Ney Amintas de Barros Braga (2014)

As usinas hidrelétricas são consideradas fontes de energia limpa e são indispensáveis para a garantia de suprimento de energia nos próximos anos em nosso país. Elas podem ocasionar desenvolvimento para as regiões em que são instaladas, mas sua construção quase sempre provoca impactos socioambientais sérios e irreversíveis. Neste contexto, o presente artigo procurou analisar a necessidade da revisão dos Planos Diretores da Usina de Segredo dos anos de 2002 e 2008 quanto ao zoneamento próximo ao reservatório para a garantia da sustentabilidade socioeconômica e ambiental de um local após a instalação da Usina. Sendo que para este estudo foi verificado o Plano Ambiental de Conservação e Uso do Entorno do Reservatório da usina Hidrelétrica de Segredo, localizada nas regiões sudoeste e centro-sul do estado do Paraná. Para atender aos objetivos, utilizou-se como metodologia a análise comparativa entre o Plano Ambiental realizado em 2008 pelo LACTEC- Instituto de Tecnologia para o Desenvolvimento e o de 2002. Os resultados revelam que embora a usina tenha trazido benefícios para a região, o pagamento de ICMS e demais compensações financeiras não demonstraram ser decisivos para as transformações dos municípios. Observou-se também alterações nos dados socioeconômicos e ambientais em 2008 em comparação aos dados de 2002, justificando portanto, a necessidade de constante avaliação dos planos estipulados no momento da construção de uma usina hidrelétrica, bem como sua adequação de acordo com as necessidades dos municípios afetados no decorrer dos anos.
Hybrid Neural Networks for Learning the Trend in Time Series (2017)

The trend of time series characterizes the intermediate upward and downward behaviour of time series. Learning and forecasting the trend in time series data play an important role in many real applications, ranging from resource allocation in data centers, load schedule in smart grid, and so on. Inspired by the recent successes of neural networks, in this paper we propose TreNet, a novel end-to-end hybrid neural network to learn local and global contextual features for predicting the trend of time series. TreNet leverages convolutional neural networks (CNNs) to extract salient features from local raw data of time series. Meanwhile, considering the long-range dependency existing in the sequence of historical trends of time series, TreNet uses a long-short term memory recurrent neural network (LSTM) to capture such dependency. Then, a feature fusion layer is to learn joint representation for predicting the trend. TreNet demonstrates its effectiveness by outperforming CNN, LSTM, the cascade of CNN and LSTM, Hidden Markov Model based method and various kernel based baselines on real datasets.
Measuring agreement in method comparison studies (1999)

Agreement between two methods of clinical measurement can be quantified using the differences between observations made using the two methods on the same subjects. The 95% limits of agreement, estimated by mean difference +/- 1.96 standard deviation of the differences, provide an interval within which 95% of differences between measurements by the two methods are expected to lie. We describe how graphical methods can be used to investigate the assumptions of the method and we also give confidence intervals. We extend the basic approach to data where there is a relationship between difference and magnitude, both with a simple logarithmic transformation approach and a new, more general, regression approach. We discuss the importance of the repeatability of each method separately and compare an estimate of this to the limits of agreement. We extend the limits of agreement approach to data with repeated measurements, proposing new estimates for equal numbers of replicates by each method on each subject, for unequal numbers of replicates, and for replicated data collected in pairs, where the underlying value of the quantity being measured is changing. Finally, we describe a nonparametric approach to comparing methods.
Membership Size, Communication Activity, and Sustainability: A Resource-Based Model of Online Social Structures (2001)

As telecommunication networks become more common, there is an increasing interest in the factors underlying the development of online social structures. It has been proposed that these structures are new forms of organizing which are not subject to the same constraints as traditional social structures. However, from anecdotal evidence and case studies it is difficult to evaluate whether online social structures are subject to the same problems as traditional social structures. Drawing from prior studies of traditional social structures and empirical analyses of longitudinal data from a sample of Internet-based groups, this exploratory work considers the role of size and communication activity in sustainable online social structures. A resource-based theory of sustainable social structures is presented. Members contribute time, energy, and other resources, enabling a social structure to provide benefits for individuals. These benefits, which include information, influence, and social support, are the basis for a social structure's ability to attract and retain members. This model focuses on the system of opposing forces that link membership size as a component of resource availability and communication activity as an aspect of benefit provision to the sustainability of an online social structure. Analyses of data from a random sample of e-mail-based Internet social structures (listservs) indicate that communication activity and size have both positive and negative effects on a structure's sustainability. These results suggest that while the use of networked communication technologies may alter the form of communication, balancing the opposing impacts of membership size and communication activity in order to maintain resource availability and provide benefits for current members remains a fundamental problem underlying the development of sustainable online social structures.
REFERENCES (1968)

Journal Article REFERENCES Get access P. E. Rock P. E. Rock Search for other works by this author on: Oxford Academic Google Scholar The British Journal of Criminology, Volume 8, Issue 3, July 1968, Pages 338–341, https://doi.org/10.1093/oxfordjournals.bjc.a049171 Published: 01 July 1968
Influence of Probiotic <i>Lactobacillus acidophilus</i> and <i>L. helveticus</i> on Proteolysis, Organic Acid Profiles, and ACE‐Inhibitory Activity of cheddar Cheeses Ripened at 4, 8, and 12 °C (2008)

The influence of adjunct bacteria on composition of cheeses, organic acid profiles, proteolysis, and ACE-inhibitory activity during ripening at 4, 8, and 12 degrees C for 24 wk was investigated. cheddar cheeses were made with starter lactococci (control), Lactobacillus acidophilus L10, and starter lactococci (L10), and L. acidophilus L10, L. helveticus H100, and starter lactococci (H100). The counts of L. acidophilus in L10 cheeses remained at >10(6) colony forming units (CFU)/g after 24 wk of ripening at 4, 8, and 12 degrees C. Concentrations of lactic, acetic, and propionic acids of the L10 and H100 cheeses were significantly higher than those of the control cheeses after 24 wk of ripening (P < 0.05). Proteolysis of the cheeses was improved as the ripening temperature increased. Water-soluble nitrogen, trichloroacetic acid soluble nitrogen, and phosphotungstic acid soluble nitrogen of L10 and H100 cheeses were significantly higher than those of the control cheeses (P < 0.05). Increase in ripening temperature from 4 degrees C to 8 and 12 degrees C increased the percentage of ACE inhibition. The IC(50) value among cheeses ripened at 4, 8, and 12 degrees C, however, was not significantly different (P > 0.05). Hence, probiotic L. acidophilus L10 can be added into cheddar cheeses to improve proteolysis and ACE-inhibitory activity.
Regioselective <i>O</i>2′,<i>O</i>3′‐Deacetylations of Peracetylated Ribonucleosides by Using Tetra‐<i>n</i>‐butylammonium Fluoride (2014)

Abstract A robust, mild, and highly regioselective deacetylation of 1,2‐diol diacetates in the presence of other acetate functions was achieved by using tetra‐ n ‐butylammonium fluoride. This method provided a single‐step route to access O 5′‐acetyl ribonucleosides, a key intermediate in the synthesis of biomedically important nucleosides and nucleotides. Moreover, it offered the general applicability of a non‐enzymatic method for the selective deacetylation of peracetylated 2′‐deoxyribonucleosides. Its synthetic utility was further demonstrated by the synthesis of molecules of biomedical interest by using this particular deacetylation reaction.
AMINO ACIDS AND PEPTIDES: II. SYNTHESIS OF ε-<i>N</i>-METHYL-<scp>L</scp>-LYSINE AND RELATED COMPOUNDS (1964)

ε-N-Methyl-L-lysine, ε-N-ethyl-L-lysine, and δ-N-methyl-L-ornithine have been synthesized by alkylation of the α-N-benzoyl-ω-N-p-toluenesulphonylamino acid. ε-N-Methyl-L-lysine was also prepared by the formaldehyde – formic acid methylation of α-N-carbobenzoxy-ε-N-benzyl-L-lysine, obtained by borohydride treatment of α-N-carbobenzoxy-L-lysine in the presence of benzaldehyde. ε-N, ε-N-Dimethyl-L-lysine, ε-N-benzyl-L-lysine, and ε-N-methyl-L-lysine ethyl ester were also prepared.
Discovery and in Vivo Evaluation of (<i>S</i>)-<i>N</i>-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9<i>H</i>-purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease (2014)

The development and optimization of a series of quinolinylpurines as potent and selective PI3Kδ kinase inhibitors with excellent physicochemical properties are described. This medicinal chemistry effort led to the identification of 1 (AMG319), a compound with an IC50 of 16 nM in a human whole blood assay (HWB), excellent selectivity over a large panel of protein kinases, and a high level of in vivo efficacy as measured by two rodent disease models of inflammation.
Image sequence coding using multiple-level segmentation and affine motion estimation (1997)

A very low bit-rate video codec using multiple-level segmentation and affine motion compensation is presented. The translational motion model is adequate to motion compensate small regions even when complex motion is involved; however, it is no longer capable of delivering satisfactory results when applied to large regions or the whole frame. The proposed codec is based on a variable block size algorithm enhanced with global motion compensation, inner block segmentation, and a set of motion models used adaptively in motion compensation. The experimental results show that the proposed method gives better results in terms of the bit rate under the same PSNR constraint for most of the tested sequences as compared with the fixed block size approach and traditional variable block size codec in which only translational motion compensation is utilized.
Technique to automatically measure electron-beam diameter and astigmatism:<scp>BEAMETR</scp> (2006)

Accuracy and resolution of scanning electron microscopy and an electron-beam lithography system directly depend on beam diameter; it should be monitored and tuned frequently. A technique is described to determine beam size using an automatic procedure. In the developed method, a specially designed and fabricated test pattern is scanned using an e-beam. A spectrum of the signal is analyzed; beam diameter is automatically determined using a software program. Results of design, fabrication, and analysis of the beam calibration test pattern are presented.
Prokineticin 1 Signaling and Gene Regulation in Early Human Pregnancy (2008)

Prokineticin 1 (PROK1) is a recently described protein with a wide range of functions including tissue-specific angiogenesis, modulation of inflammatory responses, and regulation of hematopoiesis. The objective of this study was to investigate the role of PROK1 and prokineticin receptor 1 (PROKR1) in human endometrium during early pregnancy. PROK1 and PROKR1 expression is significantly elevated in first-trimester decidua, compared with nonpregnant endometrium. Expression of PROK1 and PROKR1 was localized in glandular epithelial and various cellular compartments within the stroma. To investigate the signaling pathways and target genes activated by PROK1, we generated an endometrial epithelial cell line stably expressing PROKR1 (Ishikawa PROKR1 cells). PROK1-PROKR1 interaction induced inositol phosphate mobilization and sequential phosphorylation of c-Src, epidermal growth factor receptor, and ERK 1/2. Gene microarray analysis on RNA extracted from Ishikawa PROKR1 cells treated with 40 nm PROK1 for 8 h revealed 49 genes to be differentially regulated. A number of these genes, including cyclooxygenase (COX)-2, leukemia inhibitory factor, IL-6, IL-8, and IL-11 are regulated in the endometrium during implantation and early pregnancy. We subsequently investigated the effect of PROK1 on expression of COX-2 in Ishikawa PROKR1 cells and first-trimester decidua. COX-2 mRNA and protein expression, and prostaglandin synthesis, were elevated in response to treatment with PROK1. Moreover, expression of COX-2 by PROK1 was dependent on activation of the Gq-phospholipase C-beta-cSrc-epidermal growth factor receptor-MAPK/ERK kinase pathway. These data demonstrate that PROK1 and PROKR1 expression is elevated in human decidua during early pregnancy and that PROK1-PROKR1 interaction regulates expression of a host of implantation-related genes.
A Study of Point Defects in CVD Diamond Using Electron Paramagnetic Resonance and Optical Spectroscopy (2014)

This thesis reports research on the characterisation of the structure of point defects in chemical vapour deposition (CVD) diamond. Electron paramagnetic resonance (EPR) has been used as a tool to determine the constituent nuclei and symmetry of previously unreported EPR active defects. Optical spectroscopy has been employed to track defect concentrations and correlate optical features with EPR active defects.\n\nMulti-frequency EPR has been used to identify and characterise a previously unreported EPR signal arising from N2VH0: a vacancy bounded by two substitutional nitrogen atoms and two carbon atoms wherein a hydrogen is bonded along one of the two carbon atoms and the unpaired electron of the system is bonded along the second carbon. This defect exhibits C2v symmetry in both X- and Q-band EPR, suggesting that the hydrogen rapidly reorientates between the two equivalent carbon atoms resulting in a time averaged C2v symmetry.\n\nThe effects of annealing CVD diamond have been investigated. It has been shown that N2VH0 is produced consistently upon annealing at 1800 °C and continues to increase in intensity up to 2200 °C. The charge transfer behaviour of the N2VH0 defect is reported and the local vibrational mode (LVM) doublet at 1375 and 1378 cm-1 has been correlated with the intensity of the N2VH0 EPR signal. A calibration coefficient for the concentration of N3VH0 as calculated from the integrated intensity of the 3107 cm-1 LVM is proposed and a nitrogen assay of six samples in the as-grown and post-treated states suggest that this is a reasonable estimate.\n\nThe annealing behaviour of theWAR5 EPR centre has been investigated and found to match density functional theory (DFT) predictions for the binding energy of the OsV defect. It has been reported that the WAR5 signal can be increased in intensity upon the irradiation and annealing at 800 °C of CVD diamond grown from a C:H:O chemistry, further supporting the assignment of this signal to the OV0 defect. A new EPR signal is reported and characterised as arising from a substitutional oxygen adjacent to a vacancy wherein a hydrogen atom rapidly reorientates between the three available carbon dangling bonds (OsVH0).\n\nThe effect of irradiation and annealing on as-grown and pre-annealed CVD diamond has been investigated. It is shown that the 3324 cm-1 LVM (arising from the Ns:H-C0 defect) can be introduced into CVD diamond upon irradiation and further increased in intensity by annealing at 600 °C. The increase in 3324 cm-1 intensity has been correlated with a loss of NVH allowing a calibration correlation for this centre to be determined. Further, the reintroduction of the VnH- defect has been reported in a diamond sample which has been annealed prior to additional irradiation and annealing treatments.
Conformational Dynamics in the Interaction of SARS-CoV-2 Papain-like Protease with Human Interferon-Stimulated Gene 15 Protein (2021)

Papain-like protease (PLpro) from SARS-CoV-2 plays essential roles in the replication cycle of the virus. In particular, it preferentially interacts with and cleaves human interferon-stimulated gene 15 (hISG15) to suppress the innate immune response of the host. We used small-angle X-ray and neutron scattering combined with computational techniques to study the mechanism of interaction of SARS-CoV-2 PLpro with hISG15. We showed that hISG15 undergoes a transition from an extended to a compact state after binding to PLpro, a conformation that has not been previously observed in complexes of SARS-CoV-2 PLpro with ISG15 from other species. Furthermore, computational analysis showed significant conformational flexibility in the ISG15 N-terminal domain, suggesting that it is weakly bound to PLpro and supports a binding mechanism that is dominated by the C-terminal ISG15 domain. This study fundamentally improves our understanding of the SARS-CoV-2 deISGylation complex that will help guide development of COVID-19 therapeutics targeting this complex.
Analysis of quadratic dickson based envelope detectors for IoE sensor node applications (2017)

This paper presents a study of passive Dickson based envelope detectors operating in the quadratic small signal regime, specifically intended to be used in RF front end of sensing units of IoE sensor nodes. Critical parameters such as open-circuit voltage sensitivity (OCVS), charge time, input impedance, and output noise are studied and simplified circuit models are proposed to predict the behavior of the detector, resulting in practical design intuitions. There is strong agreement between model predictions, simulation results and measurements of 15 representative test structures that were fabricated in a 130 nm RF CMOS process.
Indexing XML Data with ToXin. (2001)

Indexing schemes for semistructured data have been developed in recent years to optimize path query processing by summarizing path information. However, most of these schemes can only be applied to some query processing stages whereas others only support a limited class of queries. To overcome these limitations we developed ToXin, an indexing scheme for XML data that fully exploits the overall path structure of the database in all query processing stages. ToXin consists of two different types of structures: a path index that summarizes all paths in the database and can be used for both forward and backward navigation starting from any node, and a value index that supports predicates over values. ToXin synthesizes ideas from object-oriented path indexes and extends them to the semistructured realm of XML data. In this paper we present the ToXin architecture, describe its current implementation, and discuss comparative performance results.
Evaluation of Intravenous Ketorolac Administered by Bolus or Infusion for Treatment of Postoperative Pain (1994)

Ready, L. B.; Brown, C. R.; Stahalgren, L. H.; Egan, K. J.; Ross, B.; Wild, L.; Moodie, J. E.; Jones, S. F.; Tommeraasen, M.; Trierwieler, M. Author Information
Adjuvant Tamoxifen Therapy for Early Stage Breast Cancer and Second Primary Malignancies (1995)

The increased incidence of colorectal and stomach cancers reported here should be regarded as tentative until supported by long-term data from a larger number of tamoxifen trials. Also, appropriate surveillance of cancer incidence is warranted for the protection of participants enrolled in current tamoxifen chemoprevention trials.
Disseminated Intravascular Coagulation (1980)

Summary An analysis was made of 346 cases of disseminated intravascular coagulation (DIC) diagnosed by utilizing a combination of laboratory tests which reflect the pathophysiology of the syndrome. The goals of the study were three fold: 1) to compare our clinical disease categories with those of other investigators, 2) to re-evaluate the diagnostic tests and, 3) most importantly, to report the results of tests infrequently performed when evaluating DIC. The patients fell into the following groups: 1) infection – 26%, 2) malignancy – 24%, 3) surgery and trauma – 19%, 4) liver disease – 8%, 5) miscellaneous – 23%. Of the diagnostic tests, those for fibrin split products (FSP), fibrin monomer and antithrombin III were the most valuable. Of the clotting proteins, factors II, V, VII and X were the most frequently decreased. The factor VIII: C levels were in conflict with the prevailing dogma. Factor VIII :C levels were decreased in only 9% of patients studied and, in fact, were increased in the majority of cases. Factor VIIIR: Ag and F VIIIR: vW were elevated in 80% of the patients evaluated. An overall mortality of 68% further confirms the dismal prognosis previously associated with DIC.
Epidural Steroids in the Management ofChronic Spinal Pain: A Systematic Review (2007)

There is moderate evidence for interlaminar epidurals in the cervical spine and limited evidence in the lumbar spine for long-term relief. The evidence for cervical and lumbar transforaminal epidural steroid injections is moderate for long-term improvement in managing nerve root pain. The evidence for caudal epidural steroid injections is moderate for long-term relief in managing nerve root pain and chronic low back pain.
Low‐energy CO<sub>2</sub> laser intestinal anastomosis: An experimental study (1988)

Intestinal anastomosis was performed in 17 Wistar rats via tissue welding by the low-energy CO2 laser. The postoperative course in the animals studied was uneventful. The integrity of the anastomosis was investigated manometrically, immediately upon completion of the anastomosis as well as 20 days later. Ten additional Wistar rats served as controls in which conventional interrupted one-layer anastomosis was performed. The results show a significant superiority of the intestinal anastomoses that were constructed by means of laser tissue welding. The time to complete the anastomosis was also significantly shorter when laser rather than manual suturing was used. Serial histological examinations for up to 90 days following surgery revealed complete healing and epithelization of the anastomotic site.
Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen (2019)

Accumulation of mutant p53 proteins is frequently found in a wide range of cancers. While conventional antibodies fail to target intracellular proteins, proteosomal degradation results in the presentation of p53-derived peptides on the tumour cell surface by class I molecules of the major histocompatibility complex (MHC). Elevated levels of such p53-derived peptide-MHCs on tumour cells potentially differentiate them from healthy tissues. Here, we report the engineering of an affinity-matured human antibody, P1C1TM, specific for the unmutated p53<sub>125-134</sub> peptide in complex with the HLA-A24 class I MHC molecule. We show that P1C1TM distinguishes between mutant and wild-type p53 expressing HLA-A24<sup>+</sup> cells, and mediates antibody dependent cellular cytotoxicity of mutant p53 expressing cells in vitro. Furthermore, we show that cytotoxic PNU-159682-P1C1TM drug conjugates specifically inhibit growth of mutant p53 expressing cells in vitro and in vivo. Hence, p53-associated peptide-MHCs are attractive targets for the immunotherapy against mutant p53 expressing tumours.