gebhart/patrepeval huggingface dataset:
Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies. (1993)

This study investigates the pathophysiology of mucormycosis caused by Rhizopus, which has been reported in 46 dialysis patients, while treated with deferoxamine (DFO). This drug aggravates mucormycosis, which we experimentally induced in guinea pigs and which lead to a shortened animal survival (P < or = 0.01). The drug's effect on Rhizopus is not mediated through the polymorphonuclear cells. Fe.DFO, the iron chelate of DFO, abolishes the fungistatic effect of serum on Rhizopus and increases the in vitro growth of the fungus (P < or = 0.0001). This effect is present at Fe.DFO concentrations > or = 0.01 microM, at which fungal uptake of radioiron from 55Fe.DFO is observed. A 1,000-fold higher concentration of iron citrate is required to achieve a similar rate of radioiron uptake and of in vitro growth stimulation as observed with Fe.DFO. These in vitro effects of Fe.DFO (1 microM) in serum on radioiron uptake and on growth stimulation are more striking for Rhizopus than for Aspergillus fumigatus and are practically absent for Candida albicans. For these three fungal species, the rates of radioiron uptake from 55Fe.DFO and of growth stimulation in the presence of Fe.DFO in serum are directly related (r = 0.886). These results underscore the major role of Fe.DFO in the pathogenesis of DFO-related mucormycosis. Pharmacokinetic changes in uremia lead to a prolonged accumulation of Fe.DFO after DFO administration, which helps explain the increased sensitivity of dialysis patients to DFO-related mucormycosis.
Influence of writing strategy on CD control for the spatial-light-modulator-based Sigma7300 DUV laser pattern generator (2004)

Critical dimension control is becoming more and more critical in the mask making industry as the exposure wavelength goes down. For laser pattern generators, the move from traditional DNQ/Novolak based towards DUV chemically amplified resist processing was initially troublesome. The relative long total exposure time of pattern generators in contrast to wafer steppers, in combination with thick quartz substrates with relatively low heat capacity, may result in reduced lithographic performance due to excessive diffusion of photogenerated acid. The photoresist polymer architecture play a large role in determining the acid diffusion characteristics and thereby also the image fidelity and resolution. In the Sigma7300 laser pattern generator the image is created by the spatial light modulator, which acts as a reflective computer-controlled reticle. By adopting a proper writing strategy, the negative effects of acid diffusion could be reduced. One component in the Sigma writing strategy is to expose the pattern in several passes that allows for dose compensation as well as averaging schemes to reduce CD errors. By adjusting the dose per pass and by keeping track of the delay times between each shot as well as the exposure path, a better control of the linewidth may be achieved for certain photoresist chemistry. In this study we present results from investigations of AZ DX 1100P and FEP-171 resists using different writing strategies.
The Control Complexity of $r$-Approval: from the Single-Peaked Case to the General Case (2013)

We investigate the complexity of $r$-Approval control problems in $k$-peaked elections, where at most $k$ peaks are allowed in each vote with respect to an order of the candidates. We show that most NP-hardness results in general elections also hold in k-peaked elections even for $k=2,3$. On the other hand, we derive polynomial-time algorithms for some problems for $k=2$. All our NP-hardness results apply to Approval and sincere-strategy preference-based Approval as well. Our study leads to many dichotomy results for the problems considered in this paper, with respect to the values of $k$ and $r$. In addition, we study $r$-Approval control problems from the viewpoint of parameterized complexity and achieve both fixed-parameter tractability results and W-hardness results, with respect to the solution size. Along the way exploring the complexity of control problems, we obtain two byproducts which are of independent interest. First, we prove that every graph of maximum degree 3 admits a specific 2-interval representation where every 2-interval corresponding to a vertex contains a trivial interval and, moreover, 2-intervals may only intersect at the endpoints of the intervals. Second, we develop a fixed-parameter tractable algorithm for a generalized $r$-Set Packing problem with respect to the solution size, where each element in the given universal set is allowed to occur in more than one r-subset in the solution.
Address Resolution Statistics (2011)

As large scale data centers continue to grow with an ever-increasing
number of virtual and physical servers there is a need to re- evaluate
performance at the network edge. Performance is often critical for
large scale data center scale applications and it is important to
minimize any unnecessary latency or load in order to streamline the
operation of services at such large scales. To extract maximum
performance from these applications it is important to optimize and
tune all the layers in the data center stack. One critical area that
requires particular attention is the link-layer address resolution
protocol that maps an IP address with the specific hardware address at
the edge of the network. The goal of this document is to characterize
this problem space in detail in order to better understand the scale
of the problem as well as to identify particular scenarios where
address resolution might have greater adverse impact on performance.
Niobium-Doped Titania Nanoparticles: Synthesis and Assembly into Mesoporous Films and Electrical Conductivity (2010)

Crystalline niobium-doped titania nanoparticles were synthesized via solvothermal procedures using tert-butyl alcohol as a novel reaction medium, and their assembly into mesoporous films was investigated. The solvothermal procedure enables the preparation of crystalline doped and undoped nonagglomerated titania nanoparticles, whose size can be controlled from 4 to 15 nm by changing the reaction temperature and time. The anatase lattice of these particles can incorporate more than 20 mol % of Nb ions. The nanoparticles can be easily dispersed at high concentrations in THF to form stable colloidal suspensions and can be assembled into uniform porous mesostructures directed by the commercial Pluronic block copolymer F127. The resulting mesoporous films show a regular mesostructure with a d spacing of about 17 nm, a uniform pore size of about 10 nm with crystalline walls, a high porosity of 43%, and a large surface area of 190 m(2) cm(-3). Substitutional doping with niobium ions drastically increases the electrical conductivity of the titania particles. The electrical conductivity of as-prepared nanoparticles containing 20 mol % of Nb is 2 x 10(-5) S cm(-1); it increases to 0.25 S cm(-1) after treatment at 600 °C in nitrogen.
Cyclophilin D, a Component of the Permeability Transition-Pore, Is an Apoptosis Repressor (2004)

The permeability transition (PT)-pore is an important proapoptotic protein complex in mitochondria. Although it is activated by many signals for apoptosis induction, the role of its various subunits in cell death induction has remained largely unknown. We found that of its components, only the voltage-dependent anion channel in the outer mitochondrial membrane and the adenine nucleotide translocator-1 (ANT-1), a PT-pore subunit of the inner membrane, are apoptosis inducers. We also report that ANT-1's direct interactor, cyclophilin D, can specifically repress ANT-1-induced apoptosis. In addition, cotransfection experiments revealed that for a diverse range of apoptosis inducers, cyclophilin D shows the same repression profile as the compound bongkrekic acid, a specific inhibitor of the PT-pore. This activity seems to be independent of its chaperone activity, the only known function of cyclophilin D to date. Importantly, cyclophilin D is specifically up-regulated in human tumors of the breast, ovary, and uterus, suggesting that inhibition of the PT-pore via up-regulation of cyclophilin D plays a role in tumorigenesis.
Gaze‐driven Object Tracking for Real Time Rendering (2013)

Abstract To efficiently deploy eye‐tracking within 3D graphics applications, we present a new probabilistic method that predicts the patterns of user's eye fixations in animated 3D scenes from noisy eye‐tracker data. The proposed method utilises both the eye‐tracker data and the known information about the 3D scene to improve the accuracy, robustness and stability. Eye‐tracking can thus be used, for example, to induce focal cues via gaze‐contingent depth‐of‐field rendering, add intuitive controls to a video game, and create a highly reliable scene‐aware saliency model. The computed probabilities rely on the consistency of the gaze scan‐paths to the position and velocity of a moving or stationary target. The temporal characteristic of eye fixations is imposed by a Hidden Markov model, which steers the solution towards the most probable fixation patterns. The derivation of the algorithm is driven by the data from two eye‐tracking experiments: the first experiment provides actual eye‐tracker readings and the position of the target to be tracked. The second experiment is used to derive a JND‐scaled (Just Noticeable Difference) quality metric that quantifies the perceived loss of quality due to the errors of the tracking algorithm. Data from both experiments are used to justify design choices, and to calibrate and validate the tracking algorithms. This novel method outperforms commonly used fixation algorithms and is able to track objects smaller then the nominal error of an eye‐tracker.
A WEIGHTED LEAST SQUARES METHOD FOR ADAPTIVE PREDICTION IN LOSSLESS IMAGE COMPRESSION (2009)

This paper is concerned with the application of the least squares method in predictive lossless image compression. Based on the observation of the limitations of ordinary least squares (OLS) method that is employed in most published algorithms, a unique weighted least squares (WLS) method is proposed. This WLS method gives a weight to the contribution of an observed sample according to the similarities between the feature at this sample and that at the pixel to be predicted. Experimental results have confirmed the superiority of the proposed method over both the OLS based method and WLS methods using alternative weighting schemes. It has been demonstrated that when coupled with other components of a lossless image compression algorithm, the proposed method can achieve a compression performance better than any other algorithms known to the authors. 1.
A loop accelerator for low power embedded VLIW processors (2004)

The high transistor density afforded by modern VLSI processes have enabled the design of embedded processors that use clustered execution units to deliver high levels of performance. However, delivering data to the execution resources in a timely manner remains a major problem that limits ILP. It is particularly significant for embedded systems where memory and power budgets are limited. A distributed address generation and loop acceleration architecture for VLIW processors is presented. This decentralized on-chip memory architecture uses multiple SRAMs to provide high intra-processor bandwidth. Each SRAM has an associated stream address generator capable of implementing a variety of addressing modes in conjunction with a shared loop accelerator.The architecture is extremely useful for generating application specific embedded processors, particularly for processing input data which is organized as a stream. The idea is evaluated in the context of a fine grain VLIW architecture executing complex perception algorithms such as speech and visual feature recognition. Transistor level Spice simulations are used to demonstrate a 159x improvement in the energy delay product when compared to conventional architectures executing the same applications.
<scp>BORIS</scp>: a free, versatile open‐source event‐logging software for video/audio coding and live observations (2016)

Summary Quantitative aspects of the study of animal and human behaviour are increasingly relevant to test hypotheses and find empirical support for them. At the same time, photo and video cameras can store a large number of video recordings and are often used to monitor the subjects remotely. Researchers frequently face the need to code considerable quantities of video recordings with relatively flexible software, often constrained by species‐specific options or exact settings. BORIS is a free, open‐source and multiplatform standalone program that allows a user‐specific coding environment to be set for a computer‐based review of previously recorded videos or live observations. Being open to user‐specific settings, the program allows a project‐based ethogram to be defined that can then be shared with collaborators, or can be imported or modified. Projects created in BORIS can include a list of observations, and each observation may include one or two videos (e.g. simultaneous screening of visual stimuli and the subject being tested; recordings from different sides of an aquarium). Once the user has set an ethogram, including state or point events or both, coding can be performed using previously assigned keys on the computer keyboard. BORIS allows definition of an unlimited number of events (states/point events) and subjects. Once the coding process is completed, the program can extract a time‐budget or single or grouped observations automatically and present an at‐a‐glance summary of the main behavioural features. The observation data and time‐budget analysis can be exported in many common formats ( TSV , CSV , ODF , XLS , SQL and JSON ). The observed events can be plotted and exported in various graphic formats ( SVG , PNG , JPG , TIFF , EPS and PDF ).
ChemInform Abstract: Polymers Containing Sulfur in the Main Chain. Synthesis, Properties, Applications (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The emotional computer (2011)

Abstract. When people talk to each other, they express their feelings through facial expressions, tone of voice, body postures and gestures. They even do this when they are interacting with machines. These hidden signals are an important part of human communication, but most computer systems ignore them. A major challenge for pervasive computing is to appreciate emotions as part of the context in which man-machine communications are conducted. This paper reports on work by a team in the Computer Laboratory at the University of Cambridge who are exploring the role of emotions in human-computer interaction. The research is also shown in the accompanying video, The Emotional Computer. 1
Treatment with n-3 polyunsaturated fatty acids after myocardial infarction: results of GISSI-prevenzione trial (2001)

GISSI-Prevenzione was conceived as a population, pragmatic trial on patients with recent myocardial infarction conducted in the framework of the Italian public health system. In GISSI-Prevenzione, patients were invited to follow Mediterranean dietary habits, and were treated with up-to-date preventive pharmacological interventions. Long-term n-3 PUFA 1 g daily, but not vitamin E 300 mg daily, was beneficial for death and for combined death, non-fatal myocardial infarction, and stroke. All the benefit, however, was attributable to the decrease in risk for overall, cardiovascular, cardiac, coronary, and sudden death.
Studies with the Rhenacarborane Cs[Re(CO)<sub>3</sub>(η<sup>5</sup>-7,8-C<sub>2</sub>B<sub>9</sub>H<sub>11</sub>)]:  Surprising Reactivity with a Range of Metal Ligand Fragments (1999)

The rhenacarborane salt Cs[Re(CO)3(η5-7,8-C2B9H11)] (1) has been synthesized in excellent yield using a new procedure. Treatment of CH2Cl2 solutions of 1 with [RuCl2(PPh3)3] yields the exo-closo complex [Re(CO)3(η5-2,3,10-(μ-H)3-exo-{RuCl(PPh3)2}-7,8-C2B9H8)] (2a). In this molecule a [RuCl(PPh3)2]+ moiety is exopolyhedrally bound via three B−H⇀Ru bonds to a closo-3,1,2-ReC2B9 system. An X-ray diffraction study revealed that one of these agostic interactions utilizes a β-B−H bond in the coordinating face of the cage, while the source of the remaining two B−H⇀Ru bonds is in the B5 belt. The anion of salt 1 also binds exopolyhedral [Rh(PPh3)2]+ and [Rh{Fe(η-C5H4PPh2)2}]+ fragments in the complexes [Re(CO)3(η5-5,10-(μ-H)2-exo-(RhL2)-7,8-C2B9H9)] (L2 = (PPh3)2 (3a), {Fe(η-C5H4PPh2)2} (3b)). Reaction of 1 with the salts [M(CO)2(THF)(η-C5H5)][BF4] (M = Fe, Ru) and [Fe(CO)2(THF)(η-C5Me5)][BF4] gives the complexes [Re(CO)3(η5-n-(μ-H)-exo-{M(CO)2(η-C5R5)}-7,8-C2B9H10)] (M = Fe, R = H, n = 10 (4a); M = Ru, R = H, n = 10 (4b); M = Fe, R = Me, n = 10 (4c), 9 (4d)) with isomers 4c and 4d formed as an inseparable mixture. An X-ray structural study on 4b revealed that there was no Re−Ru bond and that an exo-[Ru(CO)2(η-C5H5)]+ fragment is bound to the rhenacarboranyl anion by a single unsupported B−H⇀Ru interaction with an unusually long B−Ru distance (2.695(13) Å). The compounds [ReM(μ-10-H-η5-7,8-C2B9H10)(CO)3(PPh3)] (M = Cu (5a), Ag (5b)) were isolated from the reaction of 1 with sources of the fragments [M(PPh3)]+ (M = Cu, Ag). X-ray structure determinations of both species 5 revealed the presence of direct Re−M (M = Cu, Ag) connectivities bridged by carborane β-B−H⇀M interactions. In solution the complexes 5 are highly dynamic on the NMR time scale, even at low (−90 °C) temperatures.
Norrish Type II Photochemical Reaction of an Aryl Ketone on a Monolayer-Protected Gold Nanocluster. Development of a Probe of Conformational Mobility (2000)

A Norrish type II reaction of an aryl ketone monolayer-protected colloid was investigated for the first time. Photolysis of mercaptoundecanophenone-modified gold colloid, MUP-MPC, generates free acetophenone in solution and the nonene-modified MPC via the triplet excited state and the 1,4-biradical intermediate. The reaction is being developed as a probe of conformational mobility in these unique environments.
miR‐210 promotes lung adenocarcinoma proliferation, migration, and invasion by targeting <b>lysyl oxidase‐like 4</b> (2019)

Accumulating evidence has revealed that various microRNAs are deregulated and involved in lung cancer development and metastasis. miR-210 is implicated in several cancer progression. However, the detailed biological function and role of miR-210 in lung adenocarcinoma remains unclear. Our current study was aimed to investigate the mechanism of miR-210 in lung adenocarcinoma progression. We observed that miR-210 was significantly upregulated in lung cancer cell lines (A549 and H1650) in comparison to BEAS-2B cells. In addition, we found that miR-210 was greatly elevated in lung adenocarcinoma tissues. Then, it was shown that overexpression of miR-210 was able to promote lung cancer cell proliferation and colony formation ability while inhibitors of miR-210 exhibited a reversed phenomenon. Subsequently, A549 and H1650 cell migration and invasion capacity were obviously restrained by miR-210 inhibition whereas induced by miR-210 mimics. Lysyl oxidase-like 4 (LOXL4), a member of the secreted copper-dependent amine oxidases has been found to be increased or decreased in different cancer types. Here, we confirmed that LOXL4 could serve as a downstream target of miR-210 and miR-210 promoted lung cancer progression via targeting LOXL4. In A549 and H1650 cells, knockdown of LOXL4 dramatically repressed lung cancer cell proliferation, migration, and invasion. In conclusion, our study implied that miR-210 might indicate a new perspective for lung cancer.
Influenza-specific cytotoxic T-cell recognition is inhibited by peptides unrelated in both sequence and MHC restriction. (1989)

Two related peptides from the nucleoprotein (NP) sequence 365-380, derived from influenza virus isolates A/PR/8/34 and A/NT/60/68, are recognized by mutually exclusive sets of Db (Class I)-restricted cytotoxic T-lymphocyte (CTL) clones. These peptides compete with each other for presentation on Db-bearing target cells in vitro. A Kk-restricted nucleoprotein epitope (NP 50-63), which is unrelated in sequence, competes more efficiently on H-2b target cells but is not itself recognized by virus-specific CTL from influenza-infected H-2b mice. A peptide sequence from the class I molecules Cw3 and Db can also compete, but additional unrelated peptides do not do so at equimolar concentrations. Our results show that competition is at the level of the target cell and imply that the binding specificity of the class I molecule Db is broader than indicated by the immune response phenotype of the C57BL (H-2b) mouse.
An object-oriented database for intelligent multimedia presentations (2002)

We have developed an intelligent multimedia presentation design system earlier. Based on the system, we develop a multimedia database system that supports the reuse of multimedia presentations and resources. The database consists of two layers: the frame layer and the resource layer. A frame group in the first layer is the basic presentation unit to be reused. A resource group in the second layer is a collection of resources to be used by a frame or a frame group. In these two layers, we use four types of links in the database to group frames and/or resources. Also, multimedia resources are associated with a number of properties. Using these properties, we allow the user to search for resources via a database browser. The database is built on the top of a commercial object-oriented database server and run under a windowing system.
A Survey of General-Purpose Crowdsourcing Techniques (2016)

Since Jeff Howe introduced the term Crowdsourcing in 2006, this human-powered problem-solving paradigm has gained a lot of attention and has been a hot research topic in the field of computer science. Even though a lot of work has been conducted on this topic, so far we do not have a comprehensive survey on most relevant work done in the crowdsourcing field. In this paper, we aim to offer an overall picture of the current state of the art techniques in general-purpose crowdsourcing. According to their focus, we divide this work into three parts, which are: incentive design, task assignment, and quality control. For each part, we start with different problems faced in that area followed by a brief description of existing work and a discussion of pros and cons. In addition, we also present a real scenario on how the different techniques are used in implementing a location-based crowdsourcing platform, gMission. Finally, we highlight the limitations of the current general-purpose crowdsourcing techniques and present some open problems in this area.