gebhart/patrepeval huggingface dataset:
The Effect of Pre-germinated Brown Rice Intake on Blood Glucose and PAI-1 Levels in Streptozotocin-induced Diabetic Rats (2004)

Effects of pre-germinated brown rice (PGBR) on streptozotocin-induced diabetic rats were studied. The feeding of a PGBR diet to diabetic rats ameliorated the elevation of blood glucose and PAI-1 concentrations significantly, and tended to decrease the plasma lipid peroxide concentrations in comparison with rats fed a white rice diet. These results suggest that intake of PGBR instead of white rice is effective for the prevention of diabetic vascular complications.
Recent Advances in the Discovery and Development of Novel HIV-1 NNRTI Platforms (Part II): 2009-2013 Update# (2013)

The long-term usage of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) eventually leads to rapid emergence of drug-resistant viruses and severe side effect. Therefore, it is imperative to seek the additional NNRTIs with potent and broad spectrum anti-mutant activities, and excellent pharmacokinetic profiles. The discovery of etravirine, rilpivirine and other successful examples has influenced the NNRTIs design strategy profoundly. Sustained efforts in this area have led to the identification of many promising NNRTIs hits, leads and candidates for the last few years. Hence, this review aims to highlight recent prominent advances in this field as well as contributions from our laboratory toward the discovery of novel potent NNRTIs from 2009 to 2013 (by May).
Onset or breakdown voltage reduction by electrode surface roughness in air and SF<sub>6</sub> (1976)

This paper describes investigations on the influence of surface roughness on the onset or breakdown voltage in air and SF <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</inf> . Applying the streamer theorie of electrical discharges the role of ionization characteristic, gas pressure, shape and size of electrode surface protrusions is discussed. The maximum allowable field gradients of electrode surfaces with hemispherical, spherical, and filamentary irregularities were computed in air and SF <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</inf> . Pictures of a sparked electrode surface, showing slze and shape of surface roughness, were made using an electron scanning microscope. A comparison between computed breakdown field gradients of rough electrodes and experimental results obtained by employing different electrode configurations in a wide pressure range confirmed the theoretical considerations.
Negotiated Rulemaking: Involving Citizens in Public Decisions (1999)

Negotiated Rulemaking: Involving Citizens in Public Decisions
The Simulation Strategy and Its Realization in the Development Process of Active Safety and Advanced Driver Assistance Systems (2015)

<div class="section abstract"><div class="htmlview paragraph">Active Safety (AS) and Advanced Driver Assistance Systems (ADAS) can nowadays be considered as distributed embedded software systems where independent microprocessor systems communicate together using different communication protocols. Typical AS or ADAS functionality is then realized by several microprocessors communicating with each other. AS and ADAS systems interact with other Electronic Control Units in a vehicle via communication networks and gather vehicle's surroundings via camera, radar or laser sensors. Quality assurance and safety standards combined with increasing complexity and reliability demands related to vision sensing, radar sensing and data fusion, often together with a short time to market, make the development of such systems challenging. As the number of important road scenarios for the system grows, mathematical modelling and computer simulation become important engineering tasks that aim to assure the required quality and compliance with safety standards. This paper presents a simulation approach and its practical realization on a large scale in production stream projects. It is shown that the simulation can be performed on Model-in-the-Loop, Software-in-the-Loop and Hardware-in-the-Loop levels with different configurations in which some of the system components are real and some are simulated. The possible test scenarios arising from the interactions of the driver, vehicle, traffic situation and environment can be recorded during test drives and then reproduced in the simulation environment, and they can also be generated virtually. The paper illustrates both how to perform the simulation in real-time and non-real-time on a multicore processor machine in order to speed up the simulation time.</div></div>
Ambient-pressure superconductivity at the highest temperature (5 K) observed in an organic system: .beta.-(BEDT-TTF)2AuI2 (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmbient-pressure superconductivity at the highest temperature (5 K) observed in an organic system: .beta.-(BEDT-TTF)2AuI2Hau H. Wang, Mark A. Beno, Urs Geiser, Millicent A. Firestone, Kevin S. Webb, L. Nunez, G. W. Crabtree, K. Douglas Carlson, Jack M. Williams, and Cite this: Inorg. Chem. 1985, 24, 16, 2465–2466Publication Date (Print):July 1, 1985Publication History Published online1 May 2002Published inissue 1 July 1985https://doi.org/10.1021/ic00210a001RIGHTS & PERMISSIONSArticle Views157Altmetric-Citations125LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (277 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis. (1994)

The mechanisms of iron uptake from transferrin and the effects of iron chelators on these processes were investigated in human neuroblastoma cells. This study was performed because numerous reports have indicated that neuroblastoma cells contain iron-rich ferritin and are also especially sensitive to iron chelation by deferoxamine. The mechanisms of iron and transferrin uptake were examined in the human neuroblastoma cell line SK-N-MC by using human transferrin labeled with iodine 125 and iron 59. Internalized and membrane-bound 59Fe and 125I-transferrin were separated with the protease pronase. Total internalized and membrane 125I-transferrin uptake was biphasic with time, whereas total and internalized 59Fe uptake was linear. Iron uptake from transferrin was prevented by incubation at 4 degrees C and also by lysosomotrophic agents. In addition, 59Fe uptake occurred by two processes. The first process was consistent with receptor-mediated endocytosis involving internalization of transferrin bound to specific binding sites. Iron uptake also occurred by a second process, which was not saturable up to a transferrin concentration of 0.06 mg/ml. In terms of quantitative iron uptake, however, the second process was far less important than receptor-mediated endocytosis. Deferoxamine (0.25 mmol/L) only slightly increased 59Fe release from prelabeled cells; the orally effective iron chelator pyridoxal isonicotinoyl hydrazone (0.25 mmol/L) was six times more effective. Moreover, when pyridoxal isonicotinoyl hydrazone (0.2 mmol/L) was added together with labeled transferrin over a 2-hour incubation, 59Fe uptake from transferrin decreased to 18% of the control value, whereas deferoxamine (0.2 mmol/L) had no appreciable effect. Even though deferoxamine (0.1 mmol/L) had little effect on 59Fe uptake or release, it reduced uptake of tritiated thymidine to 33% of the control value after a 24-hour incubation. Three analogs of pyridoxal isonicotinoyl hydrazone, pyridoxal benzoyl hydrazone (#101), pyridoxal p-methoxybenzoyl hydrazone (#107), and pyridoxal m-fluorobenzoyl hydrazone (#109), had chelation activities comparable to that of pyridoxal isonicotinoyl hydrazone and were more effective than either deferoxamine or pyridoxal isonicotinoyl hydrazone at preventing tritiated thymidine uptake. These results suggest that the pyridoxal isonicotinoyl hydrazone analogs have potential as effective antiproliferative agents and deserve further investigation.
Synthesis and Crystal Structure of Ethyl Zinc Chloride (2006)

Crystalline ethylzinc chloride exists as a coordination polymer in the form of puckered sheets with Zn3Cl3 rings, which differ from the well-known structure of [EtZnI]∞ in adopting a boat rather than chair conformation. This contrasts with the tetrameric cubane structure suggested in 1966 based on molecular weight determinations in benzene solution.
New directions in T-cell signal transduction and transplantation tolerance (2002)

Recent therapeutic strategies to combat organ allograft rejection have focused on T-cell signaling pathways and the molecules that comprise them. While some pharmaceuticals have shown promise in blocking acute rejection, chronic graft destruction and permanent allograft acceptance in the absence of continuous immune suppression are problematic. Recent data now suggest T-cells hold the key to generation of transplantation tolerance and alleviation of long-term drug intervention. These new targets are spread across the T cell receptor, costimulatory, and T-cell growth factor signaling pathways. Development of mice deficient in T-cell genes and identification of new drug classes has accelerated our understanding of how these effector molecules contribute to T- cell activation, anergy, apoptosis, and survival. These observations have provided valuable insight into reasons for unsuccessful tolerogenic strategies while inspiring the design of new ones. This review is focused on the most recent developments in T-cell signaling cascades and their potential role for the induction of transplantation tolerance.
[Involvement of opioid peptides in corticofugal modulation of pain]. (1995)

The effect of opioid peptides on corticofugal modulation of nociceptive response in thalamic ventrobasal nucleus (VB) produced by cortical sensorimotor area II (Sm II) was observed. Single unit activities of VB neurons were extracellularly recorded by glass microelectrodes. The results showed that the nociceptive responses of VB neurons were attenuated at 0-7.5 minutes after stimulating Sm II (n = 14, P < 0.05). The inhibitory effect of stimulation of Sm II was reduced after ventriculer microinjection of 20ul of naloxone (n = 9), while marked inhibition was shown at 0-2.5 minutes after stimulating Sm II in the saline control group (n = 9, P < 0.05). There was a statistical difference at 0-2.5 minutes after stimulating Sm II between the two groups (P < 0.05). These studies suggest that opioid peptides might be involved in corticofugal modulation of pain.
PEG-Based Hybrid Block Copolymers Containing α-Helical Coiled Coil Peptide Sequences:  Control of Self-Assembly and Preliminary Biological Evaluation (2005)

This study investigates the structure and organization of a series of hybrid diblock copolymers based on poly(ethylene glycol) (PEG) and peptide sequences inspired by the coiled coil protein folding motif. Circular dichroism spectroscopy and analytical ultracentrifugation experiments indicate that the peptide sequences in these block copolymers act as structure-directing auxiliaries and mediate the formation of discrete nanosized assemblies. This self-assembly process is driven by the very specific folding and organization properties of the peptide sequences and does not involve unspecific interactions leading to large polydisperse structures. The present study also demonstrates that the self-assembly properties of the hybrid block copolymers can be controlled via selective replacement of one or two amino acid residues in the peptide block. This is an attractive feature in view of possible biomedical applications. Preliminary biological experiments show that the properties of these polymers correlate with their self-assembly behavior.
Lupus Nephropathy and Pregnancy (1984)

We describe 26 pregnancies in 19 patients with lupus nephritis. There were 4 spontaneous abortions, 2 therapeutic abortions, 4 stillbirths and 1 neonatal death. 10 deliveries were preterm and 2 fetuses were small for gestational age. 8 pregnancies were not accompanied by change of renal symptoms. Mild signs of renal involvement appeared during pregnancy in 4 patients. 6 patients showed an increase in proteinuria already present before pregnancy without renal function deterioration. A moderate worsening of renal function was observed in 3 patients. 4 patients, 3 of whom had an apparent onset of systemic lupus erythematosus during pregnancy, developed anuric acute renal failure after delivery or after late spontaneous abortion. 2 of them died from sepsis and disseminated intravascular coagulation while 2 had complete recovery of renal function. A high rate of complications was observed in patients not adequately treated during pregnancy. Renal biopsy before gestation was not predictive of the outcome of nephropathy during pregnancy, and change of histology in repeated biopsies was frequently observed.
High‐frequency jet ventilation and surfactant treatment of newborns with severe respiratory failure (1992)

Twenty-eight newborn infants (birthweight, 2.4 +/- 1.1 kg; gestational age, 34.6 +/- 6.1 weeks) with respiratory distress syndrome (RDS), meconium aspiration syndrome, or pneumonia who deteriorated in spite of optimal conventional mechanical ventilation (CMV) and exogenous surfactant therapy were treated with high-frequency jet ventilation (HFJV) and continued surfactant therapy. For enrollment, infants had to have a limited response to surfactant therapy and conventional ventilation, and meet clinical criteria that confirmed clinical deterioration and severity of illness. Study infants had received exogenous calf lung surfactant extract (CLSE) and conventional ventilation prior to the start of HFJV at 46.3 +/- 8.2 hours of age. Patients initially responded to HFJV alone with significant improvement in several respiratory variables, but deteriorated subsequently and receive additional doses of exogenous surfactant on HFJV. Exogenous surfactant and HFJV resulted in significant and sustained improvement in several respiratory variables. Only ten patients deteriorated to meet criteria for a second surfactant dose on HFJV, and two patients received a third dose. Twenty-five of the 28 patients studied survived (89%). No patients received extracorporeal membrane oxygenation or were discharged home on oxygen. The results of this pilot study suggest that the combination of HFJV and exogenous surfactant replacement may be effective in treating infants with more severe respiratory failure, and indicate the need for more extensive controlled investigations.
Analysis of Flow Field in Diesel Fuel Sprays by Particle-Image Velocimetry. (1999)

The characteristics of combustion process in internal combustion engines are affected by mixing process between the injected fuel and the ambient gas. Therefore, it is necessary to understand the flow field in diesel fuel sprays. In this study, a single spray was injected into a quiescent atmosphere with room temperature at high pressure through a single hole nozzle for simplification. To discuss the flow field in diesel sprays, structure of the spray was visualized by laser light sheet method. And, it was revealed that the vortex structure inside the spray affects the classification of droplet particles by taking microscopic photographs of the droplets with high resolution film. And applying PIV method into the spray photography, both the formation of meandering structure of the spray mainstream and the ambient gas entrainment process are clarified.
Spatial Audio Processing for Interactive TV Services (2011)

FascinatE is a European funded project that aims at developing a system to allow end users to interactively navigate around a video panorama showing a live event, with the accompanying audio automatically changing to match the selected view. The audiovisual content will be adapted to the users particular kind of device, covering anything from a mobile handset equipped with headphones to an immersive panoramic display connected with large loudspeaker setup. We describe how to handle audio content in the FascinatE context, covering simple stereo through to spatial sound fields. This will be performed by a mixture of Higher Order Ambisonics and Wave Field Synthesis. Our paper focuses on the greatest challenges for both techniques when capturing, transmitting and rendering the audio scene. 1.
A novel PUF based on cell error rate distribution of STT-RAM (2016)

Physical Unclonable Functions (PUFs) have been widely proposed as security primitives to provide device identification and authentication. Recently, PUFs based on Non-volatile Memory (NVM) are widely proposed since the promise of NVMs' wide application. In addition, NVM-based PUFs are considered to be more immune to invasive attack and simulation attack than CMOS-based PUFs. However, the existing NVM-based PUF either shows the unreliability under environmental variations or need extra modifications to the IC manufacturing process. In this work, we propose err-PUF, a novel PUF design based on the cell error rate distribution of STT-RAM. Instead of using the distribution directly, we generate a stable fingerprint based on a novel concept called Error-rate Differential Pair (EDP) without modifications to the read/write circuits. Comprehensive results demonstrate that err-PUF can achieve sufficient reliability under environmental variations, which can significantly impact the cell error rates. Moreover, compared with existing approaches, err-PUF has a higher speed and lower power consumption with negligible overhead.
Silver‐Catalyzed Intermolecular Amination of CH Groups (2007)

Teamwork: The dinuclear silver complex [Ag2(OTf)2(bp)2] (OTf=trifluoromethanesulfonate, bp=bathophenanthroline) catalyzes the intermolecular amination of saturated CH bonds by using PhINNs (Ns=p-nitrosulfonyl) as the nitrene precursor (see scheme). Preliminary investigations suggest that the dinuclear structural motif is crucial to catalytic performance. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700760_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Capturing heavy metals (1993)

For now, facilities will watch their stacks, surveying air toxics emissions while they await regulation. They're not ready to break the bank for new pollution control equipment, and maybe they won't have to. When it comes to collecting fine particulates (PM[sub 10]), most experts agree the only technologies right for the job are electrostatic precipitators (ESPs) and fabric filters, or baghouses. Of 189 hazardous air pollutants (HAPs) regulated under the new Clean Air Act, 11 are heavy metals and most are captured as PM[sub 10]. Other trace metals found in flue gas are present in a vapor state. But even mercury, one of the more difficult volatile metals to collect, could be captured by an ESP or baghouse using flue gas conditioning or dry sorbent injection, or by a spray dryer if acid gas removal is required. Vendors say their control equipment will meet future air toxics regulations with existing technology: baghouses with better fabrics and ESPs with sufficiently large units. Still, there are a lot of skeptics. Few people are convinced any of the techniques for controlling heavy metal air toxics, especially the volatiles, are a sure thing. But they all show some promise.
[Hepatocyte stimulatory peptide and its clinical significance in viral hepatitis]. (1992)

Hepatocyte stimulator peptide (HSP) is a new hepatic stimulator substance. Its monoclonal antibodies have been obtained in our laboratory. In this study, HSP was determined in the sera of 315 subjects including patients with various forms of hepatitis and healthy persons with enzyme-linked immunosorbent assay (sandwich method). It is shown that HSP level in the sera of patients with fulminant hepatitis was high and correlated with the level of tumour necrosis factor (TNF), serum bilirubin (SB) or prothrombin time (PT). It is suggested that level of HSP in the sera of the patients reflected the degree of hepatocyte injury. A formula was recommended to predict the outcome of the patients with fulminant hepatitis.
A tutorial on optimization methods for cancer radiation treatment planning (2013)

Every year, thousands of cancer patients receive radiation treatment. Radiation beams are delivered to the patient from different directions, with high precision, with the objective of maximizing dosage to the tumor, while minimizing damage to the surrounding healthy tissue. This paper is an introduction to the basic optimization problem underlying radiation treatment planning. Specifically, we show how the computation of optimal beam directions and intensities can be formulated as a convex optimization problem. We discuss some common metrics and constraints used in radiation treatment planning, using methods from optimization, medical physics, and finance and risk management. We also review some effective parallelizable methods that have been developed for solving this inherently large-scale, multi-objective optimization problem.
Chromone and Flavonoid Alkaloids: Occurrence and Bioactivity (2011)

The chromone and flavonoid alkaloids represent an unusual group of structurally diverse secondary metabolites, derived from the convergence of multiple biosynthetic pathways that are widely distributed through the plant and animal kingdoms. Many of them have been discovered through bioassay-guided chemical investigations of traditional medicines, suggesting potential therapeutic significance. Their unique structures and varied pharmacological activities may provide important new leads for the discovery of drugs with novel mechanisms of action. Potential therapeutic indications are as diverse as cancer and viral infections, inflammation and immunomodulation, neurological and psychiatric conditions, and diabetes.
The role of FCoE in I/O consolidation (2008)

Consolidation of the multiple traffic types present in current data centers over a single unified network is a big trend in the information technology industry. Extensions to 10G Ethernet are making it the most promising technology for achieving I/O consolidation. The emerging Fibre Channel over Ethernet (FCoE) protocol plays a critical role in this convergence process. This paper elaborates how FCoE leverages the ubiquity and economics of Ethernet networks while preserving the infrastructure, strengths, and tools of the existing Fibre Channel Storage Area Network (SAN) framework.