gebhart/patrepeval huggingface dataset:
Interaction of Eukaryotic Translation Initiation Factor 4G with the Nuclear Cap-Binding Complex Provides a Link between Nuclear and Cytoplasmic Functions of the m<sup>7</sup>Guanosine Cap (2001)

In eukaryotes the majority of mRNAs have an m(7)G cap that is added cotranscriptionally and that plays an important role in many aspects of mRNA metabolism. The nuclear cap-binding complex (CBC; consisting of CBP20 and CBP80) mediates the stimulatory functions of the cap in pre-mRNA splicing, 3' end formation, and U snRNA export. As little is known about how nuclear CBC mediates the effects of the cap in higher eukaryotes, we have characterized proteins that interact with CBC in HeLa cell nuclear extracts as potential mediators of its function. Using cross-linking and coimmunoprecipitation, we show that eukaryotic translation initiation factor 4G (eIF4G), in addition to its function in the cytoplasm, is a nuclear CBC-interacting protein. We demonstrate that eIF4G interacts with CBC in vitro and that, in addition to its cytoplasmic localization, there is a significant nuclear pool of eIF4G in mammalian cells in vivo. Immunoprecipitation experiments suggest that, in contrast to the cytoplasmic pool, much of the nuclear eIF4G is not associated with eIF4E (translation cap binding protein of eIF4F) but is associated with CBC. While eIF4G stably associates with spliceosomes in vitro and shows close association with spliceosomal snRNPs and splicing factors in vivo, depletion studies show that it does not participate directly in the splicing reaction. Taken together the data indicate that nuclear eIF4G may be recruited to pre-mRNAs via its interaction with CBC and accompanies the mRNA to the cytoplasm, facilitating the switching of CBC for eIF4F. This may provide a mechanism to couple nuclear and cytoplasmic functions of the mRNA cap structure.
Qualitative and quantitative temporal constraints about numerically quantified periodic events (2002)

The paper describes an integrated temporal formalism which deals with (i) quantitative information about the frame of time and the user-defined calendar-dates (periods) in which periodic events are located, (ii) (possibly multiple) numeric quantifiers indicating the number of repetitions of events and (iii) qualitative relations between periodic events. The paper defines the operations of intersection and composition of temporal specifications in the given formalism, which are used in order to perform temporal reasoning. An algorithm supporting specialised forms of reasoning about the number of repetitions of events is also described. Moreover, the paper introduces an expressive query language for extracting different types of temporal constraints from a knowledge base of temporal specifications in the formalism, sketching the reasoning algorithms needed to answer the queries.
Biochemical Composition of<i>Curcuma longa</i>L. Accessions (2012)

The essential oil composition and total phenolic content (TPC) of curcuminoids were studied in rhizomes of nine Curcuma longa L. accessions. Curcuminoids, present in commercially available turmeric rhizomes, play vital roles in various pharmacological activities. A simple, rapid, and sensitive high performance liquid chromatography photodiode array (HPLC-PDA) method was optimized for simultaneous determination of curcuminoids, namely, a mixture of curcumin, demethoxy curcumin (DMC), and bisdemethoxy curcumin (BDMC) in rhizomes of C. longa. Chromatographic separation was performed on an RP C18 column within 13 minutes (11.4 to 12.95 minutes). Elution was accomplished by the application of acetonitrile and 1.5% acetic acid in water in a gradient system with flow rate of 2.0 mL min−1. PDA was employed for qualitative and quantitative analysis. The calibration curves were found linear (0.99) for all cucuminoids; the limit of detection and quantification ranged between 1.01 µ g mL−1 to 1.16 µ g mL−1 and 2.30 µ g mL−1 to 3.05 µ g mL−1, respectively, while recovery values ranged between 97.97% to 98.32%. The amount of curcumin varied from 0.46% to 2.17%, DMC from 0.13% to 0.92% and BDMC from 0.06% to 0.52%. The validated method was successively used to determine the above compounds in C. longa rhizomes. The TPC in rhizomes ranged from 14.12 mg g−1 to 27.72 mg g−1. The chemical composition of rhizome essential oil, analyzed by gas chromatography mass spectrometry (GCMS,) showed large variations in major compounds like ar-tumerone (7.31–38.66%), β-curcumene (1.58–24.53%), and curlone (1.55–15.97%).
Concentrations of nutrients in mouse oviduct fluid and their effects on embryo development and metabolism <i>in vitro</i> (1990)

An ultramicrofluorometric technique was used to analyse the nutrient composition of mouse oviduct fluid. The concentrations of pyruvate, glucose and lactate in the vicinity of the cumulus mass were 0.37, 3.40 and 4.79 mM respectively. In the absence of cumulus cells, the concentration of pyruvate was significantly reduced, to 0.14 mM, while the concentration of glucose was significantly increased to 5.19 mM. Glutamine, which may help to overcome the '2-cell block' in mouse embryos in culture, was present at a concentration of 0.20 mM. A modified medium (MTF) in which the concentration of nutrients was similar to that in mouse oviduct fluid was prepared and its effects on embryo development and metabolism in vitro were compared with that of a conventional embryo culture medium (M16). The percentage of zygotes forming blastocysts in vitro by Day 5 was similar in both media (82% in M16, 79% in MTF). Rates of development, as assessed by cell number, were also comparable. However, the proportion of glucose consumed which was converted to lactate increased dramatically following culture; from 44% in fresh blastocysts, to 73% and 91% in blastocysts derived from 8-cell embryos cultured for 24 h in media MTF and M16 respectively.
Correlation of configuration and fluorine-19 chemical shifts of .alpha.-methoxy-.alpha.-trifluoromethylphenyl acetate derivatives (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrelation of configuration and fluorine-19 chemical shifts of .alpha.-methoxy-.alpha.-trifluoromethylphenyl acetate derivativesGlenn R. Sullivan, James A. Dale, and Harry S. MosherCite this: J. Org. Chem. 1973, 38, 12, 2143–2147Publication Date (Print):June 1, 1973Publication History Published online1 May 2002Published inissue 1 June 1973https://pubs.acs.org/doi/10.1021/jo00952a006https://doi.org/10.1021/jo00952a006research-articleACS PublicationsRequest reuse permissionsArticle Views2136Altmetric-Citations481LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mobilization of Poly(3-Hydroxybutyrate) in<i>Ralstonia eutropha</i> (2000)

Ralstonia eutropha H16 degraded (mobilized) previously accumulated poly(3-hydroxybutyrate) (PHB) in the absence of an exogenous carbon source and used the degradation products for growth and survival. Isolated native PHB granules of mobilized R. eutropha cells released 3-hydroxybutyrate (3HB) at a threefold higher rate than did control granules of nonmobilized bacteria. No 3HB was released by native PHB granules of recombinant Escherichia coli expressing the PHB biosynthetic genes. Native PHB granules isolated from chromosomal knockout mutants of an intracellular PHB (i-PHB) depolymerase gene of R. eutropha H16 and HF210 showed a reduced but not completely eliminated activity of 3HB release and indicated the presence of i-PHB depolymerase isoenzymes.
On the size and shape of multi-level context templates for compression of map images (2002)

We present a method for estimating optimal context templates that are used for conditioning the pixel probabilities in context-based image compression. The algorithm optimizes the location of the context pixels within a limited neighborhood area, and produces an ordered template as a result. The ordering can be used to determine the shape of the context template for a given template size. The optimal template size depends on the size of the image, when the template shape depends on the image type. We apply the method to the compression of multi-component map images consisting of several semantic layers represented as binary images. We estimate the shape of the context-template for each layer separately, and compress the layers as generic regions using the Joint Bi-level Image Group standard JBIG2 compression technique.
A wireless packet transmission with adaptive processing gain and transmitter power control scheme for circuit-switched and packet-switched modes integrated DS/CDMA systems (2003)

This paper proposes a wireless packet transmission scheme with adaptive processing gain (PG) and transmitter power control (TPC) techniques for circuit-switched and packet-switched modes integrated direct sequence/code division multiple access (DS/CDMA) systems. In the proposed DS/CDMA systems, as radio resource of both packet-switched and circuit-switched services is easily and dynamically controlled only by the adjustment of the received power level of both services, the proposed algorithm controls processing gain and transmitter power of the packet-switched services according to the channel load of each base station (BS). Moreover, only an open loop transmitter power control with a power margin is employed in the packet-switched mode to effectively utilize the capture effect as well as to simplify power control algorithm. Computer simulation confirms that, at the input traffic of 0.8 erl/cell, the message delay in the packet-switched mode can be decreased about 1/5 without decreasing so much the capacity of circuit switched services.
Exciton structure in sodium doped zinc oxide quantum dots (2006)

Photoluminescence spectra of electrochemically grown ZnO quantum dots doped with Na were studied at low temperature. Incorporation of Na in ZnO quantum dot is confirmed by the appearance of yellow photoluminescence at about 572nm instead of commonly observable green luminescence at about 530nm. Chemical analysis also supported the inclusion of Na in ZnO quantum dots. Rich excitonic structure was observed in photoluminescence spectra of these ZnO quantum dots. The excitonic features are analyzed in view of the published work on bulk ZnO.
Preparation and Properties of a β-d-Glucanase for the Specific Hydrolysis of β-d-Glucans (1977)

A beta-d-glucanase highly specific for glucans containing a linkage sequence ... Glc 1 --> 4 Glc 1 --> 3 Glc 1 --> 4 Glc ... has been isolated from several commercial preparations of Bacillus subtilis alpha-amylase including one purified by repeated crystallization. The beta-d-glucanase will not hydrolyze cellulose or laminarin. Gel filtration on a Bio-Gel P-200 column results in separation of the glucanase from the alpha-amylase. The enzyme is of the endo type as changes in the substrate viscosity appear long before the appearance of detectable reducing sugars. No evidence of product inhibition was revealed and appropriate substrates were converted to oligosaccharides, the quantity of which approaches theoretical yields. The products of the reaction were separated according to molecular size by use of Bio-Gel P-2 gel filtration and found to be consistent with the action pattern of the enzyme. Kinetic studies show that the enzyme has an optimum activity at pH 6.5, a V(max) of 13.9 mug glucose equivalent released/mug protein.hour, and an apparent Km of 3.4 mg of lichenan per ml. Potential application of this enzyme for the structural characterization of plant cell wall glucans is discussed.
Pulmonary stretch receptor activity in man: a comparison with dog and cat (1971)

1. The ;collision' technique has been shown to be suitable for recording orthodromic ;A' fibre activity in a whole, functioning cervical vagus nerve. This activity predominantly arises from pulmonary stretch receptors.2. The amount and frequency of discharge from pulmonary stretch receptors in man, dog and cat, have been shown to increase with inspiration and decrease with expiration-the larger the tidal volume, the greater the discharge. At the end-expiratory level in man and dog, a tonic stretch receptor discharge is present. The results in cat and dog are in broad agreement with older work using single fibre techniques.3. The stretch receptor discharge in man may be greater for a given degree of lung ;stretch' than in cat or dog. There is certainly a discharge during eupnoea in man, and this must be contrasted with the absence of a Hering-Breuer inflation reflex in adult anaesthetized man with lung inflations of the order of a eupnoeic tidal volume. Furthermore, man does not develop slow, deep breathing with bilateral vagal block.4. Since the characteristics of the activity from pulmonary stretch receptors with eupnoea in man are similar to those seen in other species, it must be concluded that this activity does not reach the central threshold to affect the respiratory centre.
Functionalized SWNT/polymer nanocomposites for dramatic property improvement (2005)

Abstract In this paper, we present results for polymer nanocomposites of poly‐ (methyl methacrylate) (PMMA) and amide‐functionalized SWNTs. The results demonstrate that even at very low loadings, 1 wt % (0.5 vol %), the mechanical and electrical properties are significantly improved. The improvement over PMMA properties exceeds the theoretical bounds for composites with the same volume fraction loading of randomly oriented, straight, individually dispersed nanotubes. The modeling and experimental results thus suggest that the nanotube bundles are well dispersed in the polymer matrix, that the functionalization significantly improves interaction with polymer, and that the interphase formed has improved mechanical properties over that of the matrix material. Loss modulus results indicate a significant difference between functionalized and nonfunctionalized tubes in the composite. Functionalized tubes result in a composite in which relaxation mechanisms are shifted by 30 °C from that of the matrix material, indicating extensive interphase regions and absence of PMMA with bulk properties. Unfunctionalized composites demonstrate a broadening of relaxation modes, but still retain the signature of bulk PMMA properties. These data suggest a morphological difference with a discrete interphase layer in unfunctionalized composites and a fully transformed matrix in the case of functionalization. This difference is consistent with electrical and mechanical property data. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 2269–2279, 2005
Internet of Things for Hearing Impaired People (2018)

The internet of things, the world of sensors could diminish the lack of hearing sense category of physically challenged. This paper focus on the hearing impaired people, who are also equally eligible to participate in this world activity as like a normal human. The sign language is universal communication language used by Speech and Hearing impaired people. There could be misinterpretation on communicating with normal hearing people. To avoid this misinterpretation and active participation in real world, we propose a reliable assistive mobile application. The application connected to the low cost wearable device for the hearing-impaired students enable them communicate with hearing people. The proposed architecture will describe a new research facet for the IoT application.
Synthesis of Exiguaflavanone K and (±)-Leachianone G (1996)

The first total synthesis of two new natural prenylflavonoids, exiguaflavanone K (1) and (±)-leachianone G (2), has been achieved by condensation of 2-hydroxy-3-prenyl-4,6-dimethoxymethoxyacetophenone (5) with hydroxy-protected benzaldehydes 6 and 7, respectively, followed by cyclization and demethoxymethylation.
Lasing with Propagation Invariant Shaped Beams (2017)

Control of the propagation properties of complex beams is desired for many applications. Here we present a novel method to generate propagation invariant shaped beams. Our method is based on a modified degenerate cavity (MDC) [1], [2], which has a huge number of degrees of freedom (300,000 modes in our system), that can be coupled and controlled. Specifically, the MDC allows direct access to both the x-space and k-space components of the laser beam. Accordingly, placing two amplitude masks, one in x-space and one in k-space, enables control of the output beam. Varying the geometric properties of the mask in x-space changes the shape of the output beam, and varying the geometric properties of the mask in k-space breaks the degeneracy between modes and forms spatial correlations (partial spatial coherence) in the output beam [1].
Modulating Affinities of Di-2-picolylamine (DPA)-Substituted Quinoline Sensors for Zinc Ions by Varying Pendant Ligands (2008)

We have developed a series of di-2-picolylamine (DPA)-substituted quinoline sensors, HQ1- 4, bearing a pendant ligand at the 8 position of quinoline. UV-vis spectra of HQ1- 4 showed similar variations to that of HQ5 but with different varying extents upon the titration of zinc ions. Fluorescence intensities of HQ1, HQ3, and HQ4 were enhanced 4-6 times upon the addition of 1 equiv of zinc ions under an aqueous buffer. Somewhat unexpectedly, HQ2 is nonfluorescent in the presence of metal ions, including zinc ions. The affinities of HQ sensors are distributed in a broad range from nanomolarity to femtomolarity by varying the pendant ligands near the coordination unit. More importantly, these new sensors exhibited very high selectivity for Zn(2+) over Na(+), K(+), Mg(2+), and Ca(2+) at the millimolar level and over other transition metal ions at the micromolar level, except for Cd(2+). These findings indicated that the incorporations of the pendant groups exerted no effect on the spectroscopic properties and selectivity of the parent fluorescent sensor, with the exception of HQ2. Finally, X-ray crystal structures of ZnHQ's revealed that the auxiliary pendant groups at the 8 position participated in zinc coordination and were able to tune the affinities of HQ sensors.
Identification of a gene expression profile associated with operational tolerance among a selected group of stable kidney transplant patients (2011)

Despite their utility, immunosuppressive treatments have numerous side effects, including infectious complications, malignancies and metabolic disorders, all of which contribute to long-term graft loss. In addition to the development of new pharmaceutical products with reduced toxicity and more comfortable modes of administration, tailoring immunosuppression according to the immune status of each patient would represent a significant breakthrough. Gene expression profiling has been shown to be a clinically relevant monitoring tool. In this paper, we have assessed the overall long-term kidney transplant outcome and attempted to identify operationally tolerant-like patients among recipients with stable clinical status at least 5 years post-transplantation. We thus measured a combination of noninvasive blood biomarkers of operational tolerance in a cohort of 144 stable patients and showed that only 3.5% exhibited a gene expression profile of operational tolerance, suggesting that such a profile can be detected under immunosuppressive therapy but that its frequency is low in kidney transplant recipients when compared with liver transplant recipients. We suggest that a rational approach to patient selection, based on a combination of clinical and biological characteristics, may help to provide a safer method for identification of patients potentially suitable for immunosuppressive drug weaning procedures.
Clinical results using the Holladay 2 intraocular lens power formula (2000)

Although the Holladay 2 formula has improved its MAE accuracy in short eyes, it was not more accurate than the Hoffer Q. The changes made in the formula to effect this improvement in MAE seem to have sacrificed the accuracy of the original Holladay formula in eyes with average and medium long axial lengths.
Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas (2009)

The identification and consideration of factors associated with recurrence and malignant progression may help guide treatment strategies aimed at delaying recurrence and preventing malignant degeneration for patients with hemispheric low-grade gliomas.
Amino-terminal sequence analysis of alphavirus polypeptides (1981)

The single late 26S mRNA of Semliki Forest virus (SFV) directs the synthesis of the four viral structural proteins, C, E3, E2, and E1, and the recently described nonstructural protein, 6K. We report here partial NH2-terminal amino acid sequences of the SFV polypeptides E3 and 6K and of p62, the precursor to E3 and E2. In addition, were have determined a partial NH2-terminal sequence of the Sindbis virus homolog of 6K, the 4.2K protein. p62 and E3 of SFV have identical NH2-terminal amino acid sequences. Comparison of the partial NH2-terminal sequences of 6K of SFV and 4.2K of Sindbis virus with the deduced amino acid sequence encoded by the 26S mRNA of each virus reveals that the genes for these peptides are located in each case between those for E2 and E1. The order of the genes on the 26S mRNA of the alphaviruses is therefore 5'-C-E3-E2-6K-E1-3'. We discuss two mechanisms by which the nascent viral glycoproteins may be inserted into the membrane of the endoplasmic reticulum.
Correction of motion artifacts in cone‐beam CT using a patient‐specific respiratory motion model (2010)

Motion correction of CBCT is feasible and yields observable improvement in the thorax and abdomen. The PCA-based model is an important component: First, by reducing deformation errors caused by the nonrigid registration and second, by relating deformation to surrogate position rather than phase, thus accommodating breathing pattern changes between imaging sessions. The accuracy of the method requires confirmation in further patient studies.
The Carboxylation of Active Methylene Compounds with Carbon Dioxide in the Presence of 18-Crown-6 and Potassium Carbonate (1992)

Abstract Active methylene compounds were carboxylated with the reagent system, 18-crown-6, potassium carbonate and carbon dioxide, in dimethyl sulfoxide at room temperature and atmospheric presssure. The concentration of the carbonate ion is important for carboxylation.
The Kanerva Machine: A Generative Distributed Memory (2018)

We present an end-to-end trained memory system that quickly adapts to new data and generates samples like them. Inspired by Kanerva's sparse distributed memory, it has a robust distributed reading and writing mechanism. The memory is analytically tractable, which enables optimal on-line compression via a Bayesian update-rule. We formulate it as a hierarchical conditional generative model, where memory provides a rich data-dependent prior distribution. Consequently, the top-down memory and bottom-up perception are combined to produce the code representing an observation. Empirically, we demonstrate that the adaptive memory significantly improves generative models trained on both the Omniglot and CIFAR datasets. Compared with the Differentiable Neural Computer (DNC) and its variants, our memory model has greater capacity and is significantly easier to train.