gebhart/patrepeval huggingface dataset:
Efficacy and safety of aerosolized tobramycin in cystic fibrosis (2001)

Aerosolized tobramycin has been extensively used in cystic fibrosis (CF) patients in order to directly deliver the antibiotic to the endobronchial site of infection, and decrease toxicity by limiting systemic absorption. Aerosolized tobramycin doses ranging from 80 mg twice or three times daily to 600 mg three times daily have been used in various clinical trials. At an 80-mg dose, preservation of pulmonary function with little or no improvement over the baseline was reported. Tobramycin, nebulized at 600 mg three times daily, significantly improved clinical and pulmonary functions and reduced the density of Pseudomonas aeruginosa in the sputum. No ototoxicity or nephrotoxicity was reported at either dose. TOBI, a tobramycin solution for inhalation, received Food and Drug Administration approval for maintenance treatment of P. aeruginosa lung infections in CF patients at least 6 years of age. Patients received TOBI nebulize 300 mg of tobramycin every 12 hr daily for 28 days, followed by 28 days off the drug in alternating cycles. In phase III trials, TOBI improved pulmonary function and decreased sputum density of P. aeruginosa compared to placebo. Serum creatinine was minimally, transiently elevated in both groups. More patients in the TOBI group reported voice alterations. All reports of tinnitus were in the TOBI group. An increased risk of emergence of resistant strains of P. aeruginosa was noted at all doses, after prolonged use.
Apollo 12 multispectral photography experiment (1971)

Apollo 12 multispectral lunar photography experiment using four camera configuration, verifying by ground photoelectric photometry
Assisted Form Filling (2009)

Although skin grafting originated 2500 to 3000 years ago, it was until the 19 th century that this technique was again introduced as a reconstructive option. While 19th century surgeons used grafts to repair their most difficult cases, skin grafting has since evolved into a modality that is routinely and sometimes preferentially used for the surgical repair of skin defects In this chapter we will discuss a relatively new type of full thickness skin graft: Preputial skin graft (PSG); regarding its indications, advantages, disadvantages and the valid reasons for the choice of PSG instead of classical full thickness skin graft (FTSG) donor sites for grafting of small defects especially in burned patients.
Ultrastructural changes in articular cartilage after experimental section of the anterior cruciate ligament of the dog knee. (1983)

Ultrastructural changes in articular cartilage were studied in joint laxity induced by severing the anterior cruciate ligament of the right knee in sixteen mature dogs. The left knees provided controls; sham operations on six other dogs consisted of stab incision only, leaving the ligament intact. Cartilage from the medial tibial condyles was examined at intervals from two days to eighteen months later. In the superficial zone of the cartilage, collagen fibrils became abnormally widely spaced at four days, and narrower fibrils appeared from seven days after operation. Chondrocytes, particularly in the middle zone, became more active, with hypertrophy of cytoplasmic organelles detectable from four days. Superficial cells were initially healthy and became more numerous while their lipid content increased. The articular surface was fissured from two months and cell degeneration was rarely seen until several months after operation. These findings correlate with previous biochemical studies and are similar to early changes noted in degeneration of human articular cartilage.
A Root-Knot Nematode Secretory Peptide Functions as a Ligand for a Plant Transcription Factor (2006)

Parasitism genes expressed in the esophageal gland cells of root-knot nematodes encode proteins that are secreted into host root cells to transform the recipient cells into enlarged multinucleate feeding cells called giant-cells. Expression of a root-knot nematode parasitism gene which encodes a novel 13-amino-acid secretory peptide in plant tissues stimulated root growth. Two SCARECROW-like transcription factors of the GRAS protein family were identified as the putative targets for this bioactive nematode peptide in yeast two-hybrid analyses and confirmed by in vitro and in vivo coimmunoprecipitations. This discovery is the first demonstration of a direct interaction of a nematode-secreted parasitism peptide with a plant-regulatory protein, which may represent an early signaling event in the root-knot nematode-host interaction.
Augmented Reality as a Training Medium for Aviation/Aerospace Application (2005)

Augmented Reality (AR) has the potential to transform aviation/aerospace training by creating new mixed reality worlds that serve as a medium for gaining work related skills. AR is a mixed reality environment generated through machine vision and computer graphics technology that merges real and virtual objects in unified, spatially integrated scenes. Using AR to develop augmented scenes in a highly memorable framework can complement human information processing, and such a complement can reveal itself in training efficiency applicable to a wide variety of work related tasks. This research determined that AR-based learning affects long term memory by reducing the amount of information forgotten after a seven day intervening time between immediate recall testing and long term retention recall testing. Continuing research in the field of AR applications for training is necessary because of human variabilities, the potential for increased learning performance and significant decreases in training time.
Protective effects of ceruloplasmin against electrolysis-induced oxygen free radicals in rat heart (1991)

The potentially injurious effects of oxygen-derived free radicals (OFR) on the myocardium can be prevented in part by pretreatment with OFR scavengers or antioxidants. Since ceruloplasmin (CP) has been shown to possess potent antioxidant activity and scavenge a variety of OFR in vitro, we have undertaken to study its protective effects against myocardial injury induced by OFR. CP was freshly purified by a fast method that minimized proteolytic enzyme degradation. Free radicals were generated by the electrolysis (10 mA DC current for 1 min) of a Krebs-Henseleit solution perfusing an isolated rat heart preparation under constant pressure conditions. CP (0.25 microM) afforded 80 and 63% protection (n = 8, p less than 0.05), respectively, against the deleterious effects of electrolysis-induced OFR on left ventricular pressure and coronary flow. The increase in left ventricular end diastolic pressure used here as an index of heart failure did not occur in the presence of 0.25 microM CP. Moreover, CP significantly reduced the increase of norepinephrine washout in the effluent perfusate after electrolysis suggesting a protection against free radical-induced injury to sympathetic nerve endings.
Habilidades y representaciones sociales de alumnos de escuelas estatales del municipio de São Paulo (Brasil) (2007)

Este trabajo hace parte de una investigación más amplia que tuvo como objetivo correlatar \nel rendimiento escolar y el desempeño en “habilidades sociales” con vistas a la formación \ndel ciudadano. Fue desarrollada junto a 741 alumnos de Escuelas Estaduales del Municipio \nde São Paulo, Brasil Teniendo en vista la correlación positiva, observada entre el \ndesempeño en “habilidades sociales” y el rendimiento escolar (principalmente en los \nexámenes de Lengua Portuguesa), fue hecha una investigación con una muestra de 95 \nalumnos, para identificar, analizar e interpretar las Representaciones Sociales sobre la \nescuela, sobre el profesor “ideal”, sobre el futuro y sobre el tipo de conocimientos \nimportantes para “vencer en la vida”. El texto discute la concepción de Destrezas de Vida y \nsu importancia para la Educación. Presenta los procedimientos metodológicos de la \ninvestigación empírica, y discute sus resultados. En las Consideraciones Finales los \nprincipales involucrados son establecidos y observados entre el contenido de las \nRepresentaciones Sociales y sus implicaciones para la Formación de Maestros y para la \nposibilidad de un avanzo en el sentido de una educación de calidad.
Multiloop Parallelisation Using Unrolling and Fission (2010)

A technique for parallelising multiple loops in a heterogeneous computing system is presented. Loops are first unrolled and then broken up into multiple tasks which are mapped to reconfigurable hardware. A performance-driven optimisation is applied to find the best unrolling factor for each loop under hardware size constraints. The approach is demonstrated using three applications: speech recognition, image processing, and the N-Body problem. Experimental results show that a maximum speedup of 34 is achieved on a 274 MHz FPGA for the N-Body over a 2.6 GHz microprocessor, which is 4.1 times higher than that of an approach without unrolling.
Hormone Replacement Therapy Is Associated With Decreased Survival in Women With Lung Cancer (2005)

HRT may affect outcomes from lung cancer adversely. Further studies examining the role of HRT use on outcomes from lung cancer, especially in women with a history of smoking, are urgently needed to clarify this important problem.
List of abbreviations (2016)

Coalmining was a notoriously dangerous industry and many of its workers experienced injury and disease. However, the experiences of the many disabled people within Britain's most dangerous industry have gone largely unrecognised by historians. This book examines the British coal industry through the lens of disability, using an interdisciplinary approach to examine the lives of disabled miners and their families.The book considers the coal industry at a time when it was one of Britain's most important industries, and follows it through a period of growth up to the First World War, through strikes, depression and wartime, and into an era of decline. During this time, the statutory provision for disabled people changed considerably, most notably with the first programme of state compensation for workplace injury. And yet disabled people remained a constant presence in the industry as many disabled miners continued their jobs or took up 'light work'. The burgeoning coalfields literature used images of disability on a frequent basis and disabled characters were used to represent the human toll of the industry.A diverse range of sources are used to examine the economic, social, political and cultural impact of disability in the coal industry, looking beyond formal coal company and union records to include autobiographies, novels and oral testimony. It argues that, far from being excluded entirely from British industry, disability and disabled people were central to its development. The book will appeal to students and academics interested in disability history, disability studies, social and cultural history, and representations of disability in literature.
Design of differential-mode wideband bandpass filters with wide stop band and common-mode suppression by means of multisection mirrored stepped impedance resonators (SIRs) (2015)

We present balanced microstrip wideband bandpass filters that simultaneously suppress the common-mode within the differential filter pass band and reject the differential-mode over a wide band above the pass band of interest. These filter characteristics are achieved by using multisection mirrored stepped impedance resonators (SIRs) transversally oriented to the filter axis and coupled through admittance inverters. Each mirrored SIR acts as a pair of independent shunt-connected series resonators for the common-mode. One of such resonators (the central one) is tuned through the patch capacitance in order to suppress the common-mode by providing a transmission zero for that mode within the differential filter pass band. For the differential-mode, the capacitances of the central resonators are virtually grounded, and the resulting inductances are determined according to the required differential-mode response. For the external resonators, the patch capacitances contribute to the differential-mode response and, combined with the inductors, provide transmission zeros useful to enhance the differential-mode stop band. The design of an order-5 quasi-Chebyshev prototype balanced filter with central frequency 2.4 GHz, 40% fractional bandwidth and 0.2 dB ripple is reported.
Research on A Novel R-¿ Wafer-handling Robot (2007)

In this paper, a novel 3 DOF R-θ wafer-handling robot, which can finish Z (up-down) movement, θ (rotation) movement, and R (radial linear stretching) movement, is presented. The mechanism and function are introduced in detail. With building the kinematics model and dynamics model of radial linear stretching component, the kinematics analysis and dynamics analysis are discussed. Based on MPC02 motion control card, the control system is formed. To meet the high velocity requirement, a time-optimal trajectory planning method with considering the constrained conditions is presented. The application to practical example shows that the proposed method is simple and effective.
Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor (1987)

Journal Article Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor Get access Magnus Pfahl, Magnus Pfahl * Cancer Research Center, La Jolla Cancer Research FoundationLa Jolla, CA 92037, USA *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Doris Benbrook Doris Benbrook Cancer Research Center, La Jolla Cancer Research FoundationLa Jolla, CA 92037, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 15, Issue 22, 25 November 1987, Page 9613, https://doi.org/10.1093/nar/15.22.9613 Published: 25 November 1987 Article history Received: 14 September 1987 Published: 25 November 1987
Preparation and properties of 2-fluoro-2,2-dinitroethyl pentafluorothioacetate (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticlePreparation and properties of 2-fluoro-2,2-dinitroethyl pentafluorothioacetateE. F. Witucki and M. B. FrankelCite this: J. Chem. Eng. Data 1979, 24, 4, 382–383Publication Date (Print):October 1, 1979Publication History Published online1 May 2002Published inissue 1 October 1979https://doi.org/10.1021/je60083a037RIGHTS & PERMISSIONSArticle Views42Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (177 KB) Get e-Alertsclose Get e-Alerts
Synthesis, Structure and Magnetism of Metal‐Organic Framework Materials with Doubly Pillared Layers (2006)

Abstract Two novel coordination polymers with a 3D pillared‐layer framework, [M II (Tdc)(4,4′‐Bpy)] n [M = Fe ( 1 ), Co ( 2 ); Tdc = thiophene‐2,5‐dicarboxylate; 4,4′‐Bpy = 4,4′‐bipyridine), have been hydrothermally synthesised and structurally characterised. A simultaneous reduction of iron(III) to iron(II) occurs under hydrothermal conditions in the self‐assembly process of complex 1 . The complexes are isostructural and, in each complex, the metal ions are linked by double μ 2 ‐carboxylate bridges in a syn ‐ syn mode, giving rise to dinuclear units that are connected to each other by chelating carboxylate groups from the Tdc ligands in an approximately perpendicular orientation to form 2D rectangle‐grid layers. The adjacent layers are held together through 4,4′‐Bpy molecules in a double‐pillar support fashion to give a 3D network with three intersecting perpendicular channels. Variable‐temperature magnetic susceptibility measurements revealed weak antiferromagnetic coupling interactions in both complexes and a field‐induced magnetic transition can be observed in 2 .(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Hippocampus dysfunction may explain symptoms of fibromyalgia syndrome. A study with single-voxel magnetic resonance spectroscopy. (2008)

The hippocampus was dysfunctional in patients with FM, as shown by lower NAA levels compared to controls, representing neuronal or axonal metabolic dysfunction. As the hippocampus plays crucial roles in maintenance of cognitive functions, sleep regulation, and pain perception, we suggest that metabolic dysfunction of hippocampus may be implicated in the appearance of these symptoms associated with this puzzling syndrome.
The timed asynchronous distributed system model (1999)

We propose a formal definition for the timed asynchronous distributed system model. We present extensive measurements of actual message and process scheduling delays and hardware clock drifts. These measurements confirm that this model adequately describes current distributed systems such as a network of workstations. We also give an explanation of why practically needed services, such as consensus or leader election, which are not implementable in the time-free model, are implementable in the timed asynchronous system model.
Association of axon guidance factor Semaphorin 3A with poor outcome in pancreatic cancer (2007)

Neural alterations and aberrantly expressed nerve-specific factors promoting tumor progression are known to contribute to pancreatic cancer's extremely poor prognosis. Despite hints that axon guidance factor semaphorin 3A (SEMA3A) may function as a tumor inhibitor, its clinical importance and therapeutic potential have not yet been explored. The present study investigated the role of SEMA3A and its receptors-plexins A1-A4 (PLXNA1-A4) and neuropilin-1 (NRP1)-in pancreatic cancer. QRT-PCR and immunohistochemical analyses revealed overexpression of SEMA3A, NRP1 and PLXNA1 in metaplastic ducts, malignant cells and nerves of cancerous specimens, and showed that elevated levels of corresponding mRNA (6.8-fold, 2.0-fold and 1.5-fold, respectively) clearly correlated with negative clinicopathological manifestations such as shorter survival (SEMA3A and PLXNA1) and a lesser degree of tumor differentiation (NRP1) in Stages I-III patients. High SEMA3A expression in pancreata of Stage IV M1 patients and in peritoneal metastases, and consequent functional studies indicated that poor clinical outcome might be related to the ability of SEMA3A to promote dissemination and invasiveness of pancreatic cancer cells through activation of multiple pathways involving Rac1, GSK3b or p42/p44 MAPK, but not E- to N-cadherin switch, MMP-9 or VEGF induction. Thus, this study is the first to quantify expression of the SEMA3A system in human malignancy and to show that overexpression of SEMA3A by nerves and transformed cells leads to a SEMA3A-rich environment which may favor malignant activities of tumor cells. Furthermore, negative clinicopathological correlations suggest that SEMA3A might represent a novel intervention target but not a treatment option for pancreatic cancer patients.
Influence of N-oxyls on the free radical autopolymerization of styrene (1999)

Through comparative studies on the controlled thermally initiated radical polymerization of styrene in the presence of N-oxyls, the effect of the type of the N-oxyls (2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (OH-TEMPO), 4-oxo-2,2,6,6-tetramethylpiperidine-N-oxyl (oxo-TEMPO) and 4-acetamido-2,2,6,6-tetramethylpiperidine-N-oxyl (acetamido-TEMPO)), as well as the concentration of the N-oxyls (3–20 mmol L–1) are discussed. The radical formation proceeds exclusively through the thermal initiation of styrene, i.e. without using any initiator. It is observed, that the thermal self-initiation of styrene increases the radical yield remarkably with the N-oxyls concentration, independent of the type of the N-oxyl. The concentration-dependent side reactions of substituted N-oxyls are remarkably more pronounced than those of unsubstituted N-oxyl. This leads to the reduction of the overall rate of polymerization (vbr) as compared to TEMPO (vbr = vbr (thermal polymerization)) with respect to the concentration, but independent of the type of substituents. Durch vergleichende Untersuchungen der kontrollierten thermisch initiierten radikalischen Polymerisation von Styrol in Gegenwart eines N-Oxyls wird der Einfluß der Art des N-Oxyls (2,2,6,6-Tetramethylpiperidin-N-oxyl (TEMPO), 4-Hydroxy-2,2,6,6-tetramethylpiperidin-N-oxyl (OH-TEMPO), 4-Oxo-2,2,6,6-tetramethylpiperidin-N-oxyl (Oxo-TEMPO), 4-Acetamido-2,2,6,6-tetramethylpiperidin-N-oxyl (Acetamido-TEMPO)) und der Konzentration des N-Oxyls (3–20 mmol L–1) diskutiert. Die Radikalbildung erfolgt ausschließlich durch die thermische Initiierung von Styrol, also ohne Zusatz eines Initiators. Beobachtet wird eine wesentliche Erhöhung der Radikalausbeute der thermischen Selbstinitiierung von Styrol in Abhängigkeit von der Konzentration des N-Oxyls, unabhängig von der Art des N-Oxyls. Die konzentrationsabhängigen Nebenreaktionen substituierter N-Oxyle sind wesentlich ausgeprägter. Das führt zur Reduzierung der Bruttopolymerisationsgeschwindigkeit (vbr) im Vergleich zu TEMPO (vbr = vbr (thermische Polymerisation)) in Abhängigkeit von der Konzentration, aber unabhängig von der Art der Substituenten.
Ceramics that Exhibit a Threshold Strength (2006)

The strength of a brittle material is not a singular value, but a distributed set of values that reflect the large variety of flaws (types and sizes) that are incorporated during processing. The distribution of strength values obtained during testing of ceramic specimens, all made at one time, are generally characterized by statistical parameters that vary with the processing method and processing period, That is, most manufactures cannot control the nature of the flaws they inadvertently incorporate during processing. Proof testing, i.e., the pre-stressing of a component to a specific value, can be used to truncate the statistical distribution, therefore defining a minimum, or threshold strength for components that do not fail the proof test. Although there is added cost to proof testing, it allows the designer to ensure reliability. As reviewed below, a threshold strength can also be obtained by incorporating periodic compressive layers within a brittle material. It is shown that the compressive layers can stop cracks larger than a given size, and an increasing stress must be applied to `push' the crack through the compressive layers to cause catastrophic failure. Factors that affect the threshold strength are reviewed.
Easy Access to Aryl‐ and Heteroaryl‐Annulated[<i>a</i>]carbazoles by the Indium‐Catalyzed Reaction of 2‐Arylindoles with Propargyl Ethers (2005)

Indoles and indium: An indium salt catalyzes the assembly of 2-arylindoles and propargyl ethers into diverse aryl- and heteroaryl-annulated[a]carbazoles in a highly regioselective manner, in which two different modes of carbon–carbon bond-forming reactions are successfully incorporated in one step (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462280_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.