gebhart/patrepeval huggingface dataset:
Harvest of Motion (2008)

This article discusses that a small-scale generator uses a catch-and-release strategy that can turn a casual stroll into useful electric energy. Many devices now require fractions of a watt continuously, often with occasional bursts of 1 to 10 W during peak activity. However, batteries occupy device volume and have limited life. Even rechargeable batteries can withstand only a finite number of charge cycles and, perhaps most important, recharging them can be inconvenient or expensive. Engineers must develop strategies to harness the abundant energy in low-frequency, time-varying motion before energy harvesting can achieve its greatest potential. Water waves, swaying and bouncing structures, and biomechanics are potential environmental energy sources that are largely out of the reach of the current vibration-inspired, motion harvesting technologies. Being able to economically convert low-speed motion to electricity will be a key to realizing practical long-term power generation for distributed devices. The Veryst energy-harvesting concept is one approach that intends to do just that. As with other energy harvesting projects, much work remains, but initial research and development suggest strong potential.
Abnormal Grignard Reactions. XII.<sup>1</sup> Sterically Hindered Aliphatic Carbonyl Compounds. II.<sup>1</sup> Ketones Containing the Dineopentylcarbinyl Group (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAbnormal Grignard Reactions. XII.1 Sterically Hindered Aliphatic Carbonyl Compounds. II.1 Ketones Containing the Dineopentylcarbinyl GroupFrank C. Whitmore and Charles T. LesterCite this: J. Am. Chem. Soc. 1942, 64, 6, 1247–1251Publication Date (Print):June 1, 1942Publication History Published online1 May 2002Published inissue 1 June 1942https://pubs.acs.org/doi/10.1021/ja01258a003https://doi.org/10.1021/ja01258a003research-articleACS PublicationsRequest reuse permissionsArticle Views256Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pain relief in chronic pancreatitis by pancreatico-jejunostomy. An institutional experience. (1997)

Effective pain control in chronic pancreatitis can be accomplished by pancreatic resection or decompression. Pancreatico-jejunostomy (PJ) has been reported to be effective for relieving pain in 70-80% of cases. The present study analyzes the authors' long-term results with PJ in the treatment of pancreatic pain. From 1963 to 1993, 49 patients with chronic pancreatitis underwent PJ for uncontrollable pain. General and radiologic characteristics, intraoperative findings and outcome were analyzed. Mean age was 35 +/- 13 years, 34 were male and 15 female. Alcoholic etiology was documented in 23 patients. Multiple pancreatic calcifications were found in 33 patients. Pancreatic biopsy confirmed chronic pancreatitis in all patients. There was one operative mortality, 12 minor, and 4 major complications. In a mean follow-up of 6.5 years, 98% of the total group was found to be free of pain. Pancreatic function remained stable in most patients. PJ is an excellent procedure for pain control that allows stable pancreatic function.
Some essential phytochemicals and the antioxidant potential in fresh and dried persimmon (2005)

Fresh persimmon contains high quantities of bioactive compounds, but is only available in the autumn and winter months. The aim of this investigation was to compare fresh and dried persimmon in order to determine whether the latter could be a substitute for fresh fruit. It was found that the contents of dietary fibers and trace elements in fresh and equivalent quantities of dried fruits were comparable. The content of total polyphenols in fresh persimmon was higher than in dried fruit, but not significantly (P > 0.05). Also the antioxidant potential in fresh persimmon as determined by all three used tests was higher than in dried fruit, but not significantly (P > 0.05). The methanol extracts of fresh and dried persimmon using the ss-carotene-linoleate model system have shown 91% and 88% of antioxidant activity at 50?microl, respectively. Radical scavenging activity with the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method has shown 88% and 84% for the same extracts and the nitric oxide test showed similar results. The best correlation was found between polyphenols, ss-carotene, DPPH and nitric oxide values (R(2) ranges between 0.9535 and 0.9934). In conclusion, both fresh and dried persimmon possess high contents of bioactive compounds and have a high antioxidant potential. When fresh fruits are not available, proper dried persimmon can be successfully used.
Redesigning the data center (2012)

Faced with rising electricity costs, leading companies have begun revolutionizing the way data centers work, from the hardware to the buildings themselves.
A novel method for throughput enhancement of adaptive OFDM in attenuated power line channels (2010)

Communications over power line channels offer inexpensive and convenient solution for signal transmission; however power line channel suffers from multipath fading and frequency selectivity along with manmade burst impulsive noise. Data spread OFDM has been evolved as an efficient adaptive modulation that controls the power of each subcarrier according to its channel transfer function. This paper aims to present a novel method using data spread OFDM to achieve higher carrier to noise ratio (CNR) and lower bit error rate (BER) in highly attenuated power line channel conditions. The simulations prove that the proposed system outperforms the conventional one under harsh power line conditions.
Restless Legs Syndrome (2003)

A 45-year-old woman reports having had nightly insomnia for years. On further questioning, she reports having uncomfortable sensations in her legs when she lies down at night. She has a feeling of needing to move her legs, which is relieved only by getting up and walking around. How should this patient be evaluated and treated?
Functional Magnetic Resonance Imaging (1994)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the 'Save PDF' action button.
Limits of Controller Performance in the Heave Disturbance Attenuation Problem (2013)

The periodic heave movement of a floating drilling rig is transferred to an elastic pipe suspended in a drilling well. The pipe oscillates up and down in the well with the period of the heave motion pushing the mud in the well and exciting pressure fluctuations in the mud in the pipe. These dynamics are described by six coupled first-order linear partial differential equations of hyperbolic type. By using the Laplace transform, the system is solved in the frequency domain and the resulting irrational transfer functions, from the periodic heave disturbance and the controlled choke flow to the distributed pressure in the annulus around the pipe, are found for different boundary conditions. We show that the response can be improved by choosing an impedance matched boundary condition which can be achieved without the use of active control. We also derive the response when a theoretical ‘perfect feed-forward control law’, which yields full attenuation of the effect of the disturbance at a single point in the well-annulus, is applied. The limitations of this ‘perfect point control’ when considering an extended section of the well is shown.
A large-bandwidth videoprocessor for high definition and double-scan TV sets (1991)

A new videoprocessor IC featuring digital cut-off control loops requiring no storage capacitors, switchable cut-off measurement lines, and improved average beam current limitation has been developed. The IC provides the video bandwidth required for HDTV and double-scan TV sets. The videoprocessor has an onchip bus-interface and an 8*8 bit register to control all important functions of the circuit. The large number of fully integrated features allows the designer to build a video board with a minimum number of external components.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The A4 Study: Stopping AD Before Symptoms Begin? (2014)

A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer's disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline.
Exploiting functional parallelism of POWER2 to design high-performance numerical algorithms (1994)

We describe the algorithms and architecture approach to produce high-performance codes for numerically intensive computations. In this approach, for a given computation, we design algorithms so that they perform optimally when run on a target machine—in this case, the new POWER2™ machines from the RS/6000 family of RISC processors. The algorithmic features that we emphasize are functional parallelism, cache/register blocking, algorithmic prefetching, loop unrolling, and algorithmic restructuring. The architectural features of the POWER2 machine that we describe and that lead to high performance are multiple functional units, high bandwidth between registers, cache, and memory, a large number of fixed- and floating-point registers, and a large cache and TLB (translation lookaside buffer). The paper gives two examples that illustrate how the algorithms and architectural features interplay to produce high-performance codes. They are BLAS (basic linear algebra subroutines) and narrow-band matrix routin es. These routines are included in ESSL (Engineering and Scientific Subroutine Library); an overview of ESSL is also given in this paper.
Linda meets Minix (1993)

Currently large interest is devoted to the development of systems supporting parallel and distributed programming over a network of workstations. We are exploring operating system support for this kind of programming, that instead is usually implemented at the user process level. We have chosen the Linda model as the basis of a programming system for networks of personal computers running Minix, a Unix-like operating system for personal computers.In this paper we shortly describe the Minix operating system and its services for remote communication based on the Amoeba protocol. We have extended Minix with new communication primitives based on Linda; we show their implementation, describing the new system architecture, and compare the new system with other Linda implementations.
Sitagliptin: Profile of a novel DPP-4 inhibitor for the treatmentof type 2 diabetes (2007)

Novel therapeutic strategies for type 2 diabetes are needed, since the current treatment options neither address all pathophysiological mechanisms nor achieve the glycemic target goals. A general islet-cell dysfunction including insulin- and glucagon-secretion defects contributes to the pathophysiology of type 2 diabetes. Improving islet function by incretin hormone action is a novel therapeutic approach. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are important incretin hormones contributing to 50-70% of the stimulation of insulin secretion after a meal. Dipeptidyl-peptidase IV (DPP-4) inhibitors inhibit the degradation of GLP-1 and GIP as well as that of other regulatory peptides. Sitagliptin, a DPP-4 inhibitor, is orally active and has been shown to be efficacious and safe in clinical studies. Sitagliptin has received approval in Mexico, the United States and other countries. Like other DPP-4 inhibitors, sitagliptin reduces hemoglobin A1c (HbA1c), fasting and postprandial glucose by glucose-dependent stimulation of insulin secretion and inhibition of glucagon secretion. Sitagliptin is weight neutral. Indirect measures show a possible improvement of beta-cell function. Sitagliptin does not cause a higher rate of hypoglycemia in comparison to metformin or placebo. This article gives an overview of the mechanisms of action, pharmacology and clinical trial results of sitagliptin.
CAR T cell therapy in solid tumors: A review of current clinical trials (2021)

Chimeric antigen receptor (CAR) T cell therapy has made tremendous strides in the arena of hematological malignancies with approved therapies in certain leukemias, lymphomas, and recently myeloma with overall highly favorable response rates. While numerous clinical studies are still ongoing for hematological malignancies, research is developing to translate the feasibility of CAR T therapy in solid organ malignancies. Unfortunately, the majority of diagnosed cancers are primarily solid tumors. Thus, a highly unmet clinical need for further research and development exists in this field. This review article highlights currently active clinical trials and a few pertinent preclinical studies involving CAR T cell therapy in solid tumors while briefly discussing study outcomes and potential key targets that may allow for the feasibility of this therapy option. Finally, we mention critical challenges existing in the solid tumor environment and discuss developing strategies that may potentially overcome the existing barriers to CAR T cell progress in solid tumors.
Pharmacokinetics and pharmacodynamics of FK143, a nonsteroidal inhibitor of steroid 5α-reductase, in healthy volunteers (1998)

The pharmacokinetics and pharmacodynamics of FK143, a new nonsteroidal inhibitor of steroid 5 alpha-reductase, were investigated in healthy volunteers, with use of plasma FK143 concentrations and serum dihydrotestosterone levels as an index for pharmacologic effects. The area under the plasma concentration-time curve from zero to infinity [AUC(0-infinity)] and maximum plasma concentration [Cmax] were increased dose proportionally after oral administration (100 to 500 mg) while subjects were in the fed state. The AUC(0-infinity) and Cmax after 500 mg oral administration during fed conditions were significantly larger than those during the fasted state, suggesting an increase of the absorption of FK143. Dihydrotestosterone concentrations after a single administration of FK143 (100 to 500 mg) during fed conditions decreased to about 65% of predose values and thereafter slowly recovered to the same levels as predose values at 168 hours. A combined pharmacokinetic-pharmacodynamic model was constructed with use of changes in dihydrotestosterone concentrations. The pharmacokinetic-pharmacodynamic profiles of FK143 after repeated administration were predictable with use of the pharmacokinetic-pharmacodynamic parameters obtained after a single administration of FK143.
Noncontact holographic detection for photoacoustic tomography (2017)

A holographic method for high-speed, noncontact photoacoustic tomography is introduced and evaluated. Relative changes of the object's topography, induced by the impact of thermoelastic pressure waves, were determined at nanometer sensitivity without physical contact. The object's surface was illuminated with nanosecond laser pulses and imaged with a high-speed CMOS camera. From two interferograms measured before and after excitation of the acoustic wave, surface displacement was calculated and then used as the basis for a tomographic reconstruction of the initial pressure caused by optical absorption. The holographic detection scheme enables variable sampling rates of the photoacoustic signal of up to 50 MHz. The total acquisition times for complete volumes with 230 MVoxel is far below 1 s. Measurements of silicone and porcine skin tissue phantoms with embedded artificial absorbers, which served as a model for human subcutaneous vascular networks, were possible. Three-dimensional reconstructions of the absorbing structures show details with a diameter of 310 μm up to a depth of 2.5 mm. Theoretical limitations and the experimental sensitivity, as well as the potential for in vivo imaging depending on the detection repetition rate, are analyzed and discussed.
Electrical conductivity particle detector for use in biological and chemical micro-analysis systems (1998)

This work introduces an integrated electrical detector for use as a conductivity or impedance based detection system for miniaturized biochemical analysis systems such as liquid chromatography or field flow-fractionation systems. Motivation for use of an on-chip conductivity detector is given. The design, fabrication, and characterization of the detector in the conductivity-based detection mode are described. Critical parameters of the conductivity detector, such as time constants, detection limits, and the effects of flow rate and applied voltage on detector response, are measured. In addition, the on-chip detector is compared to a conventional off-chip, UV-based detection system. The conductivity detector was fabricated by creating low impedance electrodes on the top and bottom surface at the end of a typical separation channel. The detector was shown to easily detect particles in the working concentration range of a typical separation system at low applied voltages. The measured time constants averaged approximately 2 seconds and changed slightly with flow rate through the detector. This time constant is acceptable for typical separations that take minutes to complete. The detector was also shown to dramatically improve resolution and reduce peak broadening for the system when compared to an off-chip detector.
Solid-phase Clq-binding fluorescence immunoassay for detection of circulating immune complexes (1982)

A fluorescence immunoassay for detection of immune complexes bound to solid-phase C1q was developed. The method was standardized by using human aggregated immunoglobulin G (IgG) to simulate immune complexes. A linear relationship existed between the concentrations of the aggregated IgG standards and the resulting fluorescent intensity. The method was found to be reproducible and capable of detecting as little as 10 micrograms of aggregated IgG per ml of heat-inactivated human serum. Antigen-antibody complexes prepared in vitro were detectable from equivalence to moderate antigen excess. Endogenous serum C1q inhibited the binding of aggregated IgG to solid-phase C1q. Pretreatment of test sera with EDTA was ineffective in eliminating this competitive effect. Heating the sera at 56 degrees C alleviated, but did not abolish, interference of endogenous C1q. Elevated levels of immune complexes were detectable in sera fro seven of nine patients wit systemic lupus erythematosus, provided the samples were heat inactivated before testing. Heparin and DNA were also found to interfere with the detection of aggregated IgG added to human serum. Assay values were falsely decreased due to competitive inhibition by these anions. Lipopolysaccharides from a variety of bacterial preparations produced no detectable interference. A comparative study was conducted on samples that had previously been tested by fluid-phase C1q-binding radioimmunoassay. The two methods were concordant in assigning normal or elevated levels of immune complexes in 70% of the samples tested. This solid-phase fluorescence immunoassay is proposed as a possible alternative to radioimmunoassay for the detection of circulating immune complexes.
Anti‐tumour immunotherapy with <scp>V</scp>γ9<scp>V</scp>δ2 <scp>T</scp> lymphocytes: from the bench to the bedside (2012)

Summary Gamma delta (γδ) Τ cells are non‐conventional T lymphocyte effectors that can interact with and eradicate tumour cells. Several data demonstrate that these T cells, which are implicated in the first line of defence against pathogens, have anti‐tumour activity against many cancers and suggest that γδ Τ cell‐mediated immunotherapy is feasible and might induce objective tumour responses. Due to the importance of γδ Τ lymphocytes in the induction and control of immunity, a complete understanding of their biology is crucial for the development of a potent cancer immunotherapy. This review discusses recent advances in γδ Τ basic research and data from clinical trials on the use of γδ Τ cells in the treatment of different cancers. It analyses how this knowledge might be applied to develop new strategies for the clinical manipulation and the potentiation of γδ Τ lymphocyte activity in cancer immunotherapy.
Candida‐associated denture stomatitis. Aetiology and management: A review: Part1. Factors influencing distribution of candida species in the oral cavity (1998)

Candida species are yeasts and within the oral cavity, Candida albicans is the most frequently isolated. There is clear evidence that C. albicans adheres to oral surfaces including acrylic dentures and mucosa. The mechanisms of attachment differ, with candidal adhesion to inert surfaces under the control of hydrophobic and electrostatic forces and adhesion to mucosa dependent on a number of complex ligand-recognition systems. Other factors within the oral environment such as saliva, pH, bacteria and hyphal formation have been shown to influence adhesion of candida species to surfaces in the mouth.
Effects of dietary supplementation of probiotics (Bacillus subtilis, Bacillus licheniformis, and Bacillus natto) on broiler muscle development and meat quality (2015)

This paper aims to evaluate the effects of probiotics (Bacillus subtilis, Bacillus licheniformis, and Bacillus natto) on muscle development and meat quality of broilers. In this study, 480 broilers (1 day old) were randomly divided into 4 groups. Group A was fed with a basal diet. The basal diets of Group B, Group C, and Group D were respectively supplemented with 50 mg/kg chlortetracycline, 200 mg/kg probiotics, and 400 mg/kg probiotics. On day 21 and day 42, in each group, 18 randomly selected broilers were tested to determine muscle performances. On day 21, compared with Group A, Group C and Group D showed no significant difference in muscle weight, muscle fiber diameter, meat color, drip loss, shear loss, or cooking loss (P > 0.05). On day 42, compared with Group A, Group C and Group D showed significant increases in muscle weight and muscle fiber diameter and significant decreases in b* value, drip loss, cooking loss, and shear force (P < 0.05). Compared with Group A and Group B, Group C and Group D showed obviously improved muscle microstructure. In conclusion, diets supplemented with 200 or 400 mg/kg probiotics could promote muscular development and meat quality of broilers in the late stage of growth.
Image sequence coding at very low bit rates: a review (1994)

This paper presents a review of promising techniques for very low bit-rate, below 64 kb/s, image sequence coding. Image sequence coding at such low rates will be a crucial technique in forthcoming visual services, e.g., visual information transmission and storage. A typical application is to transmit moving videophone scenes through the existing analog telephone lines or via a mobile channel. Two types of potential coding techniques are addressed: waveform-based image sequence coding and model-based image sequence coding.