gebhart/patrepeval huggingface dataset:
Synthesis of the Marine Natural Product Oroidin and Its <i>Z</i>-Isomer (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of the Marine Natural Product Oroidin and Its Z-Isomer†Thomas Lindel and Matthias HochgürtelView Author Information Institute of Pharmaceutical Chemistry, University of Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany Cite this: J. Org. Chem. 2000, 65, 9, 2806–2809Publication Date (Web):April 4, 2000Publication History Received2 September 1999Published online4 April 2000Published inissue 1 May 2000https://pubs.acs.org/doi/10.1021/jo991395bhttps://doi.org/10.1021/jo991395bbrief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1282Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Imidazoles,Isomerization,Mixtures,Organic compounds,Pharmaceuticals Get e-Alerts
Papillomavirus-like particle based vaccines: cervical cancer and beyond (2001)

Non-infectious human papillomavirus-like particles (VLP), composed of the L1 major capsid protein, are under active development as vaccines to prevent cervical cancer. They would presumably function primarily by generating virion-neutralising antibodies against the genital human papillomavirus (HPV) types that are the principal cause of most cervical cancers. Early phase clinical studies indicate that the VLP vaccines are well tolerated and able to consistently induce high titres of virus type-specific neutralising antibodies. Two types of second-generation VLP-based subunit vaccines with therapeutic implications, both related and unrelated to papillomavirus infection, are in preclinical development. One type seeks to induce cell-mediated immune responses, especially cytotoxic lymphocytes (CTL), against non-structural papillomavirus proteins, proteins of other viruses, or tumour associated antigens. The target antigen is incorporated into the VLPs as a fusion protein of L1 or the L2 minor capsid protein. In mouse models, this approach has generated potent CTL responses after low dose vaccination in the absence adjuvant. The second type of therapeutic VLP-based vaccine seeks to generate autoantibodies to self-antigens. The display of self polypeptides in the context of the highly ordered array of repetitive elements on the papillomavirus VLP surface abrogates the ability of the humoral immune system to functionally distinguish between foreign and self. High titre and high avidity auto-reactive IgG antibodies have been induced to both soluble (TNF-alpha) and cell surface (CCR5) central self-antigens. Vaccines based on this approach could potentially be effective alternatives to monoclonal antibody (mAb)-based therapies for a variety of disease targets.
AUTOMATIC CORRESPONDENCE FOR 3D MODELING: AN EXTENSIVE REVIEW (2005)

To generate a 3D computer model of a free-form object, multiple range images (point clouds) covering its entire surface are acquired from different viewpoints. These views are then aligned in a common coordinate basis by minimizing the distance error between their corresponding points. Establishing correspondences automatically is an inherently challenging problem due to the lack of any type of information other than the geometrical information extracted from the point clouds. Existing "automatic" correspondence techniques achieve automatism at the expense of other important specifications namely, applicability to free-form objects, accuracy, efficiency, robustness to resolution and surface sampling, robustness to overlap, robustness to noise and finally their applicability to simultaneous multiview correspondence. There is also a lack of a review paper that describes and critically analyzes these techniques. In this paper, we present such an extensive review and carry out the analysis of each technique according to the above listed indispensable criteria. Our analysis shows that none of these techniques fully meets these criteria and that there is still a need for the development of practical automatic correspondence algorithms.<br/>Read More: http://www.worldscientific.com/doi/abs10.1142S0218654305000797
Lyophilization of Vaccines (2003)

However effective a therapeutic agent may appear during clinical trials, its full potential as a marketable product can only be assured if the material can be stored and distributed in a stabilized form. This is particularly the case with labile biologlcals, such as attenuated vaccines, especially when these products need to be transported in tropical regions with limited distribution infrastructure.
Trigonometric Pulse-Forming Networks Revisited (1972)

A technique is presented for accurate approximation of transfer functions whose impulse responses are finite time duration sine and cosine pulses. By paying attention to the effects of errors in the approximation of hyperbolic functions coth <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Ts</tex> and tanh <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</tex> , an economical synthesis is obtained. The same synthesis can be used for low-error time-delay functions and magnitude functions for bandpasses.
Eye color classification for makeup improvement (2012)

The development of computer-aided solutions able to suggest the right facial makeup is a recent trend in image analysis applications, from which both amateurs and professionals could benefit significantly. The global harmony of a person is highly valuable when choosing makeup colors to make a person looking lovely. The global harmony is evaluated taking into account the color of the hair, skin and eyes, and among these features, the eyes seem to be one of the most salient features that capture an individual attention. This paper proposes a simple yet effective eye color classification scheme, compliant to the categories associated to the cosmetic software, which are often different than the classification systems used in medicine or biometrics. The color descriptors are histograms of the iris color distribution in the HSV color space, classified by multi-class Support Vector Machines, and the high accuracies achieved recommend it for digital cosmetic assistant solutions.
Physical properties of polyethylene/silicate nanocomposite blown films (2003)

Abstract Maleated polyethylene/silicate nanocomposite and maleated polyethylene/SiO 2 blown films were prepared by melt extrusion. The silicate and SiO 2 significantly affected the physical properties of the films. The former films showed higher tensile strength than the latter films. This high reinforcement effect seemed to be attributable to the strong interaction between the matrix and silicate as well as the uniform dispersion of silicate layers in the polymer matrix. The addition of silicate beyond a certain content gave a worse Elmendorf tear strength than SiO 2 . The silicate did not increase the falling dart impact strength at all. The worst Elmendorf strength apparently originated from the orientation of anisotropic silicate rather than the orientation of lamellae of the polymer matrix, and the silicate made the films more brittle. The well‐dispersed silicate layers in the polymer matrix gave almost the same optical properties as the pure polymer despite the increase in the silicate content. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 2131–2136, 2003
Interleukin-15 Is an Autocrine/Paracrine Viability Factor for Cutaneous T-Cell Lymphoma Cells (1998)

In this study we investigated the role of interleukin-15 (IL-15) in the immunobiology of cutaneous T-cell lymphoma (CTCL) cells. Using cell culture techniques, reverse transcriptase-polymerase chain reaction (RT-PCR), and immunhistochemistry we found that IL-15, like IL-7, is a growth factor for the Sézary cell line SeAx and that both cytokines prolonged the survival of malignant T cells directly isolated from Sézary syndrome (SS) patients. Both IL-15 and IL-7 were more potent than IL-2. IL-4 and IL-9, whose receptors share the same gamma chain with the receptors of IL-2, IL-7, and IL-15, did not sustain the growth of CTCL cells, indicating that signaling through the common gamma chain (gammac) is not sufficient for continuous growth. IL-13 and tumor necrosis factor-alpha (TNF-alpha) had no effect. IL-7 and IL-15 also supported the growth of SeAx cells in the presence of the apoptosis inducing agents dexamethasone and retinoic acid. The analysis of patient Sézary cells and three CTCL cell lines by RT-PCR showed that all these cells expressed IL-15 mRNA, but only a few (25%) produced IL-7 mRNA. Immunohistological analyses of skin biopsy samples of SS and Mycosis fungoides patients showed immunoreactivity for IL-15 in basal cell layer keratinocytes and in the infiltrating lymphocytes. We conclude that IL-15 is a growth or viability factor for CTCL-derived cell lines or shortly cultivated Sézary cells. The findings that IL-15 mRNA can be detected in Sézary syndrome peripheral blood mononuclear cells and that the IL-15 protein is detected in skin sections from CTCL patients suggest that IL-15 plays an important role in the biology of CTCL.
Synthesis of synchronous elastic architectures (2006)

A simple protocol for latency-insensitive design is presented.The main features of the protocol are the efficient implementation of elastic communication channels and the automatable design methodology.With this approach, finegranularity elasticity can be introduced at the level of functional units (e.g.ALUs, memories).A formal specification of the protocol is defined a nd a n e fficient s cheme f or the implementation of elasticity that involves no datapath overhead is presented.The opportunities this protocol opens for microarchitectural design are discussed.
A novel Zn-PANI dry rechargeable battery (2006)

Conducting polyaniline (PANI) powder was well mixed with graphite and acetylene black to obtain the optimum conductivity and porosity. The mixed powder was compressed into a pellet for cathode. Zinc powder was mixed with some metal powder, and compressed into a pellet used as the anode. The electrolyte comprised ZnCl2, NH4Cl, Triton-X100 and PVA at pH3. The battery has an open-circuit voltage of 1.44 V. The battery underwent charge-discharge cycle with a constant current density of 3 mA·cm-2 , within the voltage range of 0.40-1.68 V. It is found that the capacity of the battery is related to the charge-discharge cycles, the maximum capacity is 67.9 mAh·g-1 , and Coulombic efficiency is between 95% and 100%. The battery stability was also investigated after 78 d of standing without use. It is found that the battery experiences a self-discharge of less than 0.29% per day.
E3 Ligase RFWD3 Participates in Replication Checkpoint Control (2011)

RFWD3 has E3 ligase activity in vitro, but its in vivo function remains unknown. In this study we identified RFWD3 as a novel replication protein A (RPA)-associated protein. Using purified proteins, we observed a direct interaction between RPA2 and RFWD3. Further analysis showed that RFWD3 is recruited to stalled replication forks and co-localizes with RPA2 in response to replication stress. Moreover, RFWD3 is important for ATR-dependent Chk1 activation in response to replication stress. Upon replication stress, deletion of RPA2 binding region on RFWD3 impairs its localization to stalled replication forks and decreases Chk1 activation. Taken together, our results suggest that RFWD3 and RPA2 functionally interact and participate in replication checkpoint control.
Structural Requirements for RNA Editing in Glutamate Receptor Pre-mRNAs by Recombinant Double-stranded RNA Adenosine Deaminase (1996)

Pre-mRNAs for brain-expressed ionotropic glutamate receptor subunits undergo RNA editing by site-specific adenosine deamination, which alters codons for molecular determinants of channel function. This nuclear process requires double-stranded RNA structures formed by exonic and intronic sequences in the pre-mRNA and is likely to be catalyzed by an adenosine deaminase that recognizes these structures as a substrate. DRADA, a double-stranded RNA adenosine deaminase, is a candidate enzyme for L-glutamate-activated receptor channel (GluR) pre-mRNA editing. We show here that DRADA indeed edits GluR pre-mRNAs, but that it displays selectivity for certain editing sites. Recombinantly expressed DRADA, both in its full-length form and in an N-terminally truncated version, edited the Q/R site in GluR6 pre-mRNA and the R/G site but not the Q/R site of GluR-B pre-mRNA. This substrate selectivity correlated with the base pairing status and sequence environment of the editing-targeted adenosines. The Q/R site of GluR-B pre-mRNA was edited by an activity partially purified from HeLa cells and thus differently structured editing sites in GluR pre-mRNAs appear to be substrates for different enzymatic activities.
Microporous lanthanide metal-organic frameworks (2012)

Abstract Microporous metal-organic frameworks (MOFs) based on lanthanide metal ions or clusters represent a group of porous materials, featuring interesting coordination, electronic, and optical properties. These attractive properties in combination with the porosity make microporous lanthanide MOFs (Ln-MOFs) hold the promise for various applications. This review is to provide an overview of the current status of the research in microporous Ln-MOFs, and highlight their potential as types of multifunctional materials for applications in gas/solvent adsorption and separation, luminescence and chemical sensing and catalysis.
Acute Kidney Injury in Children and Its Potential Consequences in Adulthood (2012)

While emerging evidence indicates that the incidence of both acute kidney injury (AKI) and chronic kidney disease (CKD) in children is rising, and the etiologies are dramatically changing, relatively little is currently known regarding the potential for transition from AKI to CKD. In both situations, early intervention can significantly improve the dismal prognosis. Fortunately, recent data have validated a multidimensional AKI classification system for children, and led to the investigation of the chronic kidney sequelae in many pediatric populations with AKI, or at risk for AKI (children with hemolytic uremic syndrome, neonates or those exposed to repeated nephrotoxic medications). The purpose of this article is to review the changing epidemiology of pediatric AKI and its potential effect on the development of CKD in children.
N-terminal type I modules required for fibronectin binding to fibroblasts and to fibronectin's III1 module (1997)

Assembly of fibronectin fibrils occurs at the surface of substrate-attached cells and is mediated by the first to the fifth type I modules in the N-terminal 70 kDa portion of the molecule. The first type III module (III1) of fibronectin, not present in the 70 kDa portion, contains a conformation-dependent binding site for the 70 kDa N-terminal region of fibronectin, suggesting that the III1 module on cell-surface fibronectin may serve as a binding site for fibronectin's N-terminus on substrate-attached cells. To explore this possiblility, we compared the ability of mutant recombinant 70 kDa proteins containing deletions of one or several of the first five type I modules to bind to fibroblasts and to III1. Proteins containing the fourth and fiftBiomolecular Chemistry and Medicine, University of Wisconsin, Madison, WI 53706U.S.A. Assembly of fibronectin fibrils occurs at the surface of substrate-attached cells and is mediated by the first to the fifth type I modules in the N-terminal 70 kDa portion of the molecule. The first type III module (III1) of fibronectin, not present in the 70 kDa portion, contains a conh as 70 kDa deletion mutants lacking I4 and I5 also bound to the cell surface, and deletion mutants lacking I1-3 and I4-5 both competed only partially for binding of 125I-labelled fibronectin or 70 kDa protein. These data indicate that the N-terminal part of fibronectin binds to III1 via I4 and I5 and that interactions in addition to that of I4 and I5 with III1 are important for cell-surface-mediated fibronectin polymerization.
Comparison of Indocyanine Green Angiography and Laser Speckle Contrast Imaging for the Assessment of Vasculature Perfusion (2012)

These 2 methods should be used together to obtain a complete understanding of tissue perfusion.
Motion vector re-estimation and dynamic frame-skipping for video transcoding (2002)

This paper investigates the dynamic frame-skipping strategy in video transcoding. To speed up the operation, a video transcoder usually reuses the decoded motion vectors to reencode the video sequences at a lower bit-rate. When frame-skipping is allowed in a transcoder, those motion vectors can not be reused because the motion vectors of the current frame is no longer estimated from the immediate past frame. To reduce the computational complexity of motion vectors re-estimation, a bilinear interpolation approach is developed to overcome this problem. Based on these interpolated motion vectors, the search range can be much reduced. Furthermore, we propose a frame rate control scheme which can dynamically adjust the number of skipped frames according to the accumulated magnitude of motion vectors. As a result, the decoded sequence can present much smoother motion.
Cephalic Index: A Fetal Gestational Age Dependent Biometric Parameter (2011)

Objective: There is limited data on fetal cranial dimensions of Nigerian population. This is important because the study of normal and abnormal growth of children has become an increasingly important part of the practice and research in all fields related to child health; more so that prenatal and postnatal growth is one continuous process. Material & Methods: In a cross-sectional study conducted on 13,740 Nigerian fetuses ranging from 12 weeks to 42 weeks at the Centre for Reproductive Health Research Jos; biparietal diameter and occipitofrontal diameter were measured using ultrasound machine in order to calculate fetal cephalic index. The values were statistically analyzed after deriving the relevant indices. Results: The regression equation was calculated between gestational age and cephalic index of fetuses of Nigerian women. This equation y = 1.3x + 59.88; showed a linear relationship which was stronger from 12 to 16 weeks of gestation. Above 16 weeks gestation, the relationship was found to be quite weak. Coefficient of correlation is r2 = 0.9844 (p < 0.0001). Conclusion: The fetal skulls were found to be mesocephalic in the early weeks and brachycephalic at term. Key Words: Cranial dimensions; Cephalic index; Brachycephalic DOI: 10.3126/ajms.v1i2.3145Asian Journal of Medical Sciences 1 (2010) 45-48
Current management of ischemic mitral regurgitation. (2005)

Severe coronary artery disease and myocardial infarction can be complicated by ischemic mitral regurgitation (IMR). IMR results from left ventricular remodeling after myocardial infarction and in rare instances can accompany acute ischemia. A better understanding of the pathophysiology of IMR and increased awareness of its negative impact on long-term survival explain the recent rise in the number of patients referred for surgical correction of IMR at the time of coronary revascularization. The most common mechanism of IMR is Carpentier's type IIIb dysfunction, for which an undersized remodeling annuloplasty is the treatment of choice. In this article we define ischemic mitral regurgitation and review its pathophysiology, clinical presentations, diagnosis, indication for surgery, and management.
HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects (2007)

The lysosphingolipid sphingosine 1-phosphate (S1P) is a component of HDL. Findings from a growing number of studies indicate that S1P is a mediator of many of the cardiovascular effects of HDL, including the ability to promote vasodilation, vasoconstriction, and angiogenesis, protect against ischemia/reperfusion injury, and inhibit/reverse atherosclerosis. These latter cardioprotective effects are being shown to involve the S1P-mediated suppression of inflammatory processes, including reduction of the endothelial expression of monocyte and lymphocyte adhesion molecules, decreased recruitment of polymorphonuclear cells to sites of infarction, and blocking of cardiomyocyte apoptosis after myocardial infarction. This review article summarizes the evidence that S1P as a component of HDL serves to regulate vascular cell and lymphocyte behaviors associated with cardiovascular (patho)physiology.
Radiolabelled Regulatory Peptides for Imaging and Therapy (2007)

Radiolabelled peptides have shown to be an important class of radiopharmaceuticals for imaging and therapy of malignancies expressing receptors of regulatory peptides. These peptides have high affinity and specificity for their receptors. The majority of these receptors are present at different levels in different tissues and tumours. This review focuses on the application of regulatory peptides radiolabelled with (67/68)Ga, (90)Y, (111)In or (177)Lu. Due attention is given to the current status of research, limitations and future perspectives of the application of these radiolabelled peptides for imaging and radiotherapy. It also covers elements of the basic science and preclinical and clinical aspects in general, however, mostly based on somatostatin receptor-mediated imaging and therapy. New analogues, chelators, radionuclides and combinations thereof are discussed.
Continuously tunable and coherent terahertz radiation by means of phase-matched difference-frequency generation in zinc germanium phosphide (2003)

Continuously tunable and coherent radiation has been obtained in the ranges of 66.5–300 μm and 72.7–237 μm for two configurations of phase-matched difference-frequency generation, respectively, in zinc germanium phosphide. The highest output peak powers are measured to be 36 and 19 W for the two configurations, respectively.
Pitting Corrosion: Comparison of Treatments With Extreme-Value–Distributed Responses (2006)

In this article we develop statistical extreme-value theory as a method to validate and improve experiments with extremal responses, and to extrapolate and compare results. Our main motivation is corrosion tests performed at Volvo Car Company. Localized, or “pitting,” corrosion can limit the usefulness of aluminum, magnesium, and other new lightweight materials and makes judicious choice of alloys and surface treatments necessary. Standard methods for evaluating corrosion tests are based on weight loss due to corrosion and ANOVA. These methods fail in two ways. The first is that it usually is not weight loss but the risk of perforation (i.e., the depth of the deepest pit) that is of interest. The second is that the standard ANOVA assumption of homogeneity of variances typically is not satisfied by pit depth measurements, and that normality does not give credible extrapolation into extreme tails.