gebhart/patrepeval huggingface dataset:
Clinical management of blunt trauma patients with unilateral rib fractures: A randomized trial (1995)

Optimal pain management is essential in blunt trauma patients sustaining significant chest trauma. The purpose of this randomized prospective trial was to measure the difference in pulmonary function in nonintubated patients with unilateral multiple rib fractures receiving two modalities of pain relief: systemic narcotic medications alone or local anesthetics given by intrapleural catheter (IPCs). Forty-two patients were randomized to receive systemic narcotic medications or IPCs for pain control. The patients with IPCs statistically had more compromised pulmonary function as measured by forced vital capacity (FVC) on admission; however, they tended toward a greater objective improvement of FVC on discharge. When analyzing a cohort of severely impaired patients (initial FVC < 20%), half of the systemic medication patients compared to only 10% of the IPC group failed and required another mode of therapy. Catheter complications were minor and did not contribute to overall morbidity. The IPC patients had fewer failures than the systemic medication patients.
An Enhanced QoS Provisioning Approach for Video Streams using Cross Layer Design in IEEE 802.16 (2012)

Wimax networks are increasingly deployed for commercial use because of its high bandwidth. This has necessitated application level changes in QoS provisioning techniques. In this paper, we propose an efficient method at the application layer of the wimax architecture. The video stream is partitioned at the application layer into I, P and B frames. Frames corrupted at receiver are detected using negative acknowledgements received from the physical layer. Probability of Byte Loss (BL) is calculated at physical layer which is used to calculate the redundant data. Redundant data is communicated from PHY layer to application layer via link layer using cross-layer signalling mechanism. Redundant data is piggybacked into the subsequent frame and sent only if BL is less than 0.2. This technique has improved the throughput of the network considerably which is evident from the performance analysis.
Calificación de sustracción de tarjeta de crédito y extracciones de dinero y compras realizadas con la tarjeta. Concepto de llave falsa. Delitos de falsedad y estafa continuados (2001)

Enunciado: 
Juan E., con antecedentes penales por delito de robo y falsedad en documento de identidad, y Maria I., sin antecedentes penales, ambos mayores de edad, se aproximaron hasta Dolores F., que se encontraba en la estacion de ferrocarril de PG de la ciudad de X y, aprovechando un descuido de la misma, le cogieron de un bolso que esta llevaba una cartera monedero que contenia 22.000 ptas. en efectivo y una tarjeta de credito de la Red 6000 de la entidad CM con el numero secreto apuntado en un borde de la tarjeta. Se dirigieron con ello a un cajero automatico de la entidad mencionada situado en la plaza de C. y realizaron tres reintegros de 50.000 ptas. cada uno, guardandose el dinero Juan E. A continuacion, fueron a la tienda de ropa «GC», sita en la misma calle, y efectuaron la compra de diversas prendas de ropa, tanto para Juan como para Maria, pagando todas ellas con la tarjeta citada, en varios recibos, por importes totales de 27.190, 47.360, 29.760 y 23.900 ptas., e imitando Maria para el pago de las prendas, la firma de la titular de la tarjeta en los documentos de pago. Cuando Juan y Maria salian de la tienda, fueron detenidos, ocupandoseles la tarjeta, las prendas adquiridas, los resguardos de compra y 171.000 pesetas en efectivo. 
• Cuestiones planteadas: 
Analisis juridico de los delitos cometidos.
Introduction to Acoustical Holography (1967)

The principle of reconstructed wavefronts is extended to the formation of visual pictures of acoustical waves. The important relationships used in conventional optical holography that also apply to acoustics are briefly reviewed. It is shown that image formation using the principles of acoustical holography yields better results than do conventional acoustical lens systems, particularly in the presence of turbulence and turbidity. Experiments are described in which coarsely sampled acoustical holograms, made with sound wavelengths of 0.64 in. and longer, have successfully reconstructed images of acceptable quality. The signal-to-noise ratio in a sampled acoustical hologram is shown to increase with the number of sampled points as well as with the reduction in the size of the sampling probe. Applications of acoustical holography in different fields are discussed.
A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders (2017)

The X-chromosome harbors hundreds of disease genes whose associated diseases predominantly affect males. However, a subset, including neurodevelopmental disorders, Rett syndrome (RTT), fragile X syndrome, and CDKL5 syndrome, also affects females. These disorders lack disease-specific treatment. Because female cells carry two X chromosomes, an emerging treatment strategy has been to reawaken the healthy allele on the inactive X (Xi). Here, we focus on methyl-CpG binding protein 2 (MECP2) restoration for RTT and combinatorially target factors in the interactome of Xist, the noncoding RNA responsible for X inactivation. We identify a mixed modality approach combining an Xist antisense oligonucleotide and a small-molecule inhibitor of DNA methylation, which, together, achieve 30,000-fold MECP2 up-regulation from the Xi in cultured cells. Combining a brain-specific genetic <i>Xist</i> ablation with short-term 5-aza-2'-deoxycytidine (Aza) treatment models the synergy in vivo without evident toxicity. The Xi is selectively reactivated. These experiments provide proof of concept for a mixed modality approach for treating X-linked disorders in females.
Detection of<i>N</i><sup>6</sup>-methyladenosine based on the methyl-sensitivity of MazF RNA endonuclease (2017)

We found that Escherichia coli MazF toxin, an ACA-sequence-specific endoribonuclease, was sensitive to N<sup>6</sup>-methyladenosine (m6A), representing the first m6A-sensitive RNA cleavage enzyme. The methyl-sensitivity of MazF allowed simple analyses of both m6A demethylase and methyltransferase activity. Furthermore, the approach could be used for inhibitor screening.
Seeding Techniques (1999)

A seed provides a template for the assembly of molecules to form a crystal with the same characteristics as the crystal from which it originated. Seeding has often been used as a method of last resort, rather than a standard practice. Recently, these techniques have gained popularity, in particular, macroseeding, used to enlarge the size of crystals. Seeding has many more applications, and the use of seeding in crystallization can simplify the task of the crystallographer even when crystals can be obtained without it. We will explore the various seeding techniques, and their applications, in the growth of large single crystals and the methods by which we may attempt to obtain crystals that diffract to higher resolution. Crystallogenesis can be divided into two separate phases. The first being the screening of crystallization conditions to obtain the first crystals, the second consisting of the optimization of these conditions to improve crystal size and quality. Seeding can be used advantageously in both these situations. The first stage in crystallogenesis consists of the discovery of initial crystals, crystalline aggregates, or microcrystalline precipitate. This may result from a standardized screening method (1, 2), a systematic method (3), an incomplete factorial search (see Chapter 4 and refs 4 and 5), or by extensive screening of many conditions. This may be bypassed by starting with seeds from crystals of a related molecule that has been previously crystallized. Molecules that have been obtained by genetic or molecular engineering of a previously crystallized macromolecule fall in this category. This method is termed cross-seeding. It has been used to obtain crystals of pig aspartate aminotransferase starting with crystal from the chicken enzyme (6) and between native and complexed Fab molecules (7). Whatever the method used to obtain the initial crystals, seeding may provide a fast and effective way to facilitate the optimization of growth conditions without the uncertainty which is intrinsic in the process of spontaneous nucleation. The streak seeding technique can be used to carry out a search quickly and efficiently over a wide range of growth conditions.
Progression in gastric carcinoma relative to the ratio of CD44 epithelial variant transcript to CD44 hematopoietic variant transcript (1996)

BACKGROUND It has been suggested that CD44 splice variants play a role in the progression of certain epithelial cancers and non-Hodgkin's lymphoma. In this study, we investigated the epithelial variant/hematopoietic variant (E/H) ratio (the amount of the CD44 epithelial variant transcript relative to the CD44 hematopoietic variant transcript) in human gastric carcinoma compared with normal gastric mucosa. METHODS The ratio was determined for tumors and adjacent noncancerous mucosa from 30 gastric carcinoma patients using reverse transcription-polymerase chain reaction and Southern blotting. We also determined the tumor (T)E/H − noncancerous mucosa (N)E/H (the difference between E/H ratios of tumor tissue and adjacent noncancerous mucosa) and examined these measurements for correlations with the pathologic features of gastric carcinoma, as well as for their usefulness as an indicator of tumor progression. RESULTS The E/H ratio in tumor tissue was significantly higher than in adjacent noncancerous mucosa (P < 0.01). The TE/H − NE/H in patients with lymph node metastases was 0.16 ± 0.11, compared with 0.07 ± 0.08 in cases without lymph node metastases (P < 0.05). Significant correlations also were observed between the TE/H − NE/H and the depth of invasion, blood vessel invasion, and lymphatic vessel invasion (P < 0.03, P < 0.03, and P < 0.01, respectively). CONCLUSIONS Our results suggest that increases in the E/H ratio may be a useful indicator of progression in gastric carcinoma. Cancer 1996;77:25-9.
Silicidation-induced band gap shrinkage in Ge epitaxial films on Si (2004)

Ge epitaxial films on Si grown at high temperatures show a shrinkage in the direct band gap EgΓ as a result of the tensile strain accumulated during the cooling process after growth, making it a promising candidate for effective photon detection in L-band telecommunications. However, because of strain relaxation at temperatures &gt;750 °C, only about 0.20% tensile strain can be accumulated at most. This leads to a direct band gap of 0.773 eV, corresponding to 1605 nm and is not enough to cover the whole L band (1561–1620 nm). In this letter, we report the strain enhancement in epitaxial Ge films induced by the formation of C54TiSi2 on the backside of the Si wafers. The backside C54-TiSi2 layer not only forms a good electric contact, but also increases the tensile strain of the Ge film on the front side from 0.20% to 0.24% and a further direct band gap shrinkage from 0.773 to 0.765 eV, corresponding to 1620 nm, which covers the whole L band. Since the silicidation process is compatible with Si complementary metal-oxide-semiconductor technology, this technique is promising to achieve low cost L-band photon detection completely with tensile strained Ge on Si.
Application-Specific Memory Interleaving Enables High Performance in FPGA-based Grid Computations (2006)

Current generations of FPGAs create possibilities for innovative, application-specific computation pipelines. In many cases, the pipeline can fully exploit the FPGA's parallelism only when multiple operands are available concurrently, requiring clusters of values to be fetched from memory. These clusters of values often have fixed organization, as in the eight grid points around an off-grid position that are needed for 3D interpolation of a value at that position. This paper presents a technique for creating custom interleaving of the FPGA's on-chip memories, giving access to the entire cluster of values in one memory cycle. This technique works on grids of 2, 3, or more dimensions, on many non-rectangular grids, and on cluster organization specific to each application. The authors report the initial version of a design tool that inputs the relative positions of grid points in the access cluster, and produces synthesizable HDL code for the custom-interleaved memory
Interfacial Reactions of Metal-Hydrogen Systems Measured by Electrochemical Methods (1989)

Interfacial reactions of H atoms on transition metals have been studied by an electrochemical method. In the method, the current in a short circuit of a H 2 |0.1 N H 2 SO 4 | Metal cell and the recovery process of the electromotive force after breaking the short circuit were measured as functions of temperature. Thermodynamical quantities and the adsorption energies of H atoms on the metal surface were derived from the present measurements, and the interfacial reaction mechanism of metal-hydrogen system was discussed as functions of the physical adsorption energy of hydrogen and the work function on metal.
Use of Sonication for the Coupling of Sterically Hindered Substrates in the Phenolic Mitsunobu Reaction (2003)

A vast rate increase in the Mitsunobu reaction of phenols with alcohols where either or both are sterically hindered has been achieved by the use of high concentration combined with sonication.
Immunogens containing sequences from antigen Pf332 induce <i>Plasmodium falciparum</i>‐reactive antibodies which inhibit parasite growth but not cytoadherence (1995)

Immunogens based upon sequences from the P. falciparum asexual blood stage antigen Pf332 were assessed for their capacity to induce antibodies inhibiting parasite growth or cytoadherence of infected erythrocytes in vitro. Selection of the Pf332 sequences was based on their reactivity with the human monoclonal antibody (MoAb) 33G2 which inhibits parasite growth as well as cytoadherence in vitro. Octameric multiple antigen peptides (MAP) were assembled based upon either a trimer of the minimal epitope recognized by the MoAb, VTEEI, or a Pf332 sequence including that motif, SVTEEIAEEDK. A dimer of SVTEEIAEEDK was also expressed in Escherichia coli, genetically fused to ZZ, two IgG-binding domains of staphylococcal protein A. Rabbit antibodies elicited by the immunogens reacted with Pf332 in immunofluorescence and in ELISA with Pf332 peptides which were also recognized by MoAb 33G2. The MAP with branched (VTEEI)3 peptide induced the highest titres of P. falciparum-reactive antibodies. In contrast to MoAB 33G2, none of the polyclonal Pf332 reactive sera cross-reacted with repeat sequences of the malaria antigen Pf155/RESA. The polyclonal Pf332-reactive antibodies inhibited parasite growth efficiently but had no or very low inhibitory effect in a cytoadherence assay. Thus, while Pf332 may be an important target for parasite neutralizing antibodies its involvement in cytoadherence is unclear.
Cooperative effects of Rho and mechanical stretch on stress fiber organization (2005)

The small GTPase Rho regulates the formation of actin stress fibers in adherent cells through activation of its effector proteins Rho-kinase and mDia. We found in bovine aortic endothelial cells that inhibitions of Rho, Rho-kinase, and mDia (with C3, Y27632, and F1F2Delta1, respectively) suppressed stress fiber formation, but fibers appeared after 10% cyclic uniaxial stretch (1-Hz frequency). In contrast to the predominately perpendicular alignment of stress fibers to the stretch direction in normal cells, the stress fibers in cells with Rho pathway inhibition became oriented parallel to the stretch direction. In cells with normal Rho activity, the extent of perpendicular orientation of stress fibers depended on the magnitude of stretch. Expressing active RhoV14 plasmid in these cells enhanced the stretch-induced stress fiber orientation by an extent equivalent to an additional approximately 3% stretch. This augmentation of the stretch-induced perpendicular orientation by RhoV14 was blocked by Y27632 and by F1F2Delta1. Thus, the activity of the Rho pathway plays a critical role in determining both the direction and extent of stretch-induced stress fiber orientation in bovine aortic endothelial cells. Our results demonstrate that the stretch-induced stress fiber orientation is a function of the interplay between Rho pathway activity and the magnitude of stretching.
Quality assessment of cross‐species hybridization of CHO transcriptome on a mouse DNA oligo microarray (2008)

DNA microarray technology has been widely utilized for species with extensive genome sequence information available. Given the limited genomic information pertaining to Chinese hamster ovary (CHO) cell line, cross-species hybridization using mouse microarrays provides a viable alternative. In this study, the utility of mouse Affymetrix microarrays for transcriptome profiling in CHO cells was assessed by hybridizing identical sets of cRNA samples from CHO cells on both mouse and CHO Affymetrix microarrays. Expression level measured by probe sets for orthologous transcripts on the two microarrays was compared. Only a fraction of the orthologous probes which detected expression calls in same species hybridization were similarly called present in cross species hybridization. In further analysis at the 25-mer probe level, it was revealed that specific hybridization signals were detectable by the subset of mouse probes that have a high degree of homology to the corresponding CHO sequences. The feasibility of cross species hybridization for quantifying the extent of differential expression was assessed by comparing transcript levels of CHO cells cultivated with and without sodium butyrate. While same species hybridization gave consistent degree of differential expression calls in replicated runs, a much inferior ability in quantifying differential expression was seen with cross species hybridization. Our results demonstrate that through detailed analysis of homology at the probe pair level, a subset of probes on existing mouse Affymetrix oligo-array can be used successfully for transcriptome profiling of CHO cells.
Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst (2010)

This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.
Cadmium telluride photovoltaic manufacturing technology. Annual subcontract report, 7 January 1994--6 January 1995 (1995)

This report describes work performed by Golden Photon, Inc. (GPI), to conduct research under the PVMaT program, Phase 2B. The objective of the research is to advance GPI`s manufacturing technology, reduce module production costs, increase average module performance, and identify ways to expand production capacity. More specifically, the tasks established for Phase I were to design and install leasehold improvements for the 2-MW production line; to improve and develop product design, efficiency, and marketability; to ensure uninterrupted qualified supplies and raw materials for production; to address environmental, health, and safety issues encountered during production of photovoltaic modules; and to reduce the cost of manufacturing modules. During the first half of this reporting period, the development, design, and debugging of cell interconnection equipment critical to start-up was completed. During the second and third quarters, the primary focus was on the substrate deposition steps (tin oxide, cadmium sulfide, and cadmium telluride) and cell interconnection steps (division). In general, process development, engineering, and quality teams continued to focus on identifying, baselining, and improving (through redesign) actual process equipment operation parameters to meet the required PV panel specifications and improve process throughput rates and yields.
Agranulocytosis induced by propylthiouracil: evidence of a drug dependent antibody reacting with granulocytes, monocytes and haematopoietic progenitor cells (1986)

A patient with agranulocytosis and myeloid marrow hypoplasia following a second exposure to propylthiouracil (PTU) was studied for antibodies against mature blood cells and bone marrow precursor cells. During the acute phase of the agranulocytosis, significant growth inhibition of the myeloid committed progenitor cells (CFU-GM) was found following incubation with complement, indicating the presence of in-vivo cell bound cytotoxic antibodies. Using immunofluorescence and complement dependent cytotoxicity techniques it was demonstrated that acute phase and recovery phase sera contained circulating antibodies, reactive not only with differentiated granulocytes and monocytes but also with myeloid and erythroid (BFU-E/CFU-E) progenitor cells. Complement dependent lysis of the progenitor cells was facilitated by preincubation with PTU. These results indicate that the agranulocytosis was mediated by a PTU dependent antibody that affected both mature blood cells and bone precursor cells.
Orthologous endogenous retroviruses exhibit directional selection since the chimp-human split (2015)

ERVs differ from other selfish DNA in the extent to which they diverge and appear to have measurable effects on hosts, even after fixation. The effects are strongest for HERV-H and suggest that the HERV-H transcriptome has recently evolved under the influence of directional selection. As there are many HERV-H loci distributed across the ape lineage, our results suggest that in future this family can be used to model the evolutionary consequences of ERV exaptation in primates and other mammals.
<i>Helicobacter pylori</i>Infection and Non-Ulcer Dyspepsia: The Effect of Treatment with Colloidal Bismuth Subcitrate (1991)

A study was undertaken to determine the role of Helicobacter pylori in non-ulcer dyspepsia (NUD) and to determine the efficacy of colloidal bismuth subcitrate (CBS) in the treatment of NUD. Seventy-one patients were randomly allocated (double blind) to CBS or placebo, two tablets twice daily for 4 weeks. The severity of dyspepsia was scored and endoscopies performed before and after treatment, and antral biopsy specimens were taken for bacteriologic and histologic examination. Forty patients had H. pylori infection, and all had changes of chronic active gastritis. H. pylori was cleared from 17 to 21 patients (81%) treated with CBS, whereas none of the 19 patients treated with placebo cleared the bacteria. Improvement in histology was noted in 15 of 21 patients (71.4%) treated with CBS, whereas no improvement was noted in any of the placebo controls. Thirty-one patients were negative for H. pylori. All had either normal gastric histology or minor degrees of inflammation. Seventeen of these patients received CBS, and 14 received placebo. All groups reported improvement in the symptom score; however, the H. pylori-positive, CBS-treated group recorded a significantly higher improvement than the other groups (p less than 0.001). Relapse of H. pylori infection after initial clearance of the bacteria was high. Twelve of 16 patients evaluated relapsed 1 month after withdrawal of CBS.