gebhart/patrepeval huggingface dataset:
Differential Tissue Expression of Three 35-kDa Annexin Calcium-dependent Phospholipid-binding Proteins (1989)

We have purified three 35-kDa calcium- and phospholipid-binding proteins from rat liver. These three calcimedins bind to phosphatidylserine in a calcium-dependent manner and have been termed 35 alpha, 35 beta, and 35 gamma based on their relative charge as determined by isoelectric focusing. Purification of the three 35-kDa calcimedins is achieved by phenyl-Sepharose, ion exchange, and gel filtration chromatography. Antibody was produced against the annexin consensus peptide, Lys-Ala-Met-Lys-Gly-Leu-Gly-Thr-Asp-Glu, which was derived from the sequence of several Ca2+/phospholipid-binding proteins including calpactin, lipocortin, endonexin II, 67-kDa calelectrin, lymphocyte 68-kDa protein, and protein II. Recognition of each 35-kDa calcimedin by anticonsensus sequence antibody places them in this protein family. Antibodies against each 35-kDa calcimedin were raised and purified by antigen-affinity chromatography. Each antibody is monospecific for the respective 35-kDa calcimedin. Immunological cross-reactivity defines 35 alpha, 35 beta, and 35 gamma as lipocortins III, IV, and V, respectively. Surveys by immunoblot analysis using these monospecific antibodies demonstrate a markedly different tissue expression pattern for each 35-kDa calcimedin. Furthermore, the levels of 35 alpha, 35 beta, and 35 gamma are differentially regulated in maturing rat ovary and uterus. Each calcimedin has been localized by indirect immunofluorescence within specific cell types. These results support the concept that mediation of the intracellular calcium signal can occur via multiple pathways through several related yet independent mediator proteins.
Towards better understanding of black-box auto-tuning: a comparative analysis for storage systems (2018)

Modern computer systems come with a large number of configurable parameters that control their behavior. Tuning system parameters can provide significant gains in performance but is challenging because of the immense number of configurations and complex, nonlinear system behavior. In recent years, several studies attempted to automate the tuning of system configurations; but they all applied only one or few optimization methods. In this paper, for the first time, we apply and then perform comparative analysis of multiple black-box optimization techniques on storage systems, which are often the slowest components of computing systems. Our experiments were conducted on a parameter space consisting of nearly 25,000 unique configurations and over 450,000 data points. We compared these methods for their ability to find near-optimal configurations, convergence time, and instantaneous system throughput during auto-tuning. We found that optimal configurations differed by hardware, software, and workloads-- and that no one technique was superior to all others. Based on the results and domain expertise, we begin to explain the efficacy of these important automated black-box optimization methods from a systems perspective.
An approach for using AVHRR data to monitor U.S. Great Plains Grasslands (1996)

Abstract Environmental monitoring requires regular observations regarding the status of the landscape‐ The concept behind most monitoring efforts using satellite data involve deriving normalized difference vegetation index (NDVI) values or accumulating the NDVI over a specified time period. These efforts attempt to estimate the continuous growth of green biomass by using continuous additions of NDVI as a surrogate measure. To build upon this concept, this study proposes three refinements; 1) use an objective definition of the current growing season to adjust the time window during which the NDVI is accumulated, 2) accumulate only the NDVI values which are affected by green vegetation, and 3) base monitoring units upon land cover type. These refinements improve the sensitivity of detecting interannual vegetation variability, reduce the need for extensive and detailed knowledge of ground conditions and crop calendars, provide a framework in which several types of monitoring can take place over diverse land cover types, and provide an objective time frame during which monitoring takes place.
Screening for new yeast mutants affected in mannosylphosphorylation of cell wall mannoproteins (2003)

We have carried out a screen of 622 deletion strains generated during the EUROFAN B0 project to identify non-essential genes related to the mannosylphosphate content of the cell wall. By examining the affinity of the deletants for the cationic dye alcian blue and the ion exchanger QAE-Sephadex, we have selected 50 strains. On the basis on their reactivity (blue colour intensity) in the alcian blue assay, mutants with a lower phosphate content than wild-type cells were then arranged in groups defined by previously characterized mutants, as follows: group I (mnn6), group II (between mnn6 and mnn9) and group III (mnn9). Similarly, strains that behaved like mnn1 (i.e. a blue colour deeper than wild-type) were included in group VI. To confirm the association between the phenotype and a specific mutation, strains were complemented with clones or subjected to tetrad analysis. Selected strains were further tested for extracellular invertase and exoglucanase. Within groups I, II and III, we found some genes known to be involved in oligosaccharide biosynthesis (ALG9, ALG12, HOC1), secretion (BRE5, COD4/COG5, VPS53), transcription (YOL072w/THP1, ELP2, STB1, SNF11), cell polarity (SEP7, RDG1), mitochondrial function (YFH1), cell metabolism, as well as orphan genes. Within group VI, we found genes involved in environmentally regulated transduction pathways (PAL2 and RIM20) as well as others with miscellaneous or unknown functions. We conclude that mannosylphosphorylation is severely impaired in some deletants deficient in specific glycosylation/secretion processes, but many other different pathways may also modulate the amount of mannosylphosphate in the cell wall.
A software-based technique enabling composable hierarchical preemptive scheduling for time-triggered applications (2013)

Many embedded real-time applications are typically time-triggered and preemptive schedulers are used to execute tasks of such applications. Orthogonally, composable partitioned embedded platforms use preemptive time-division multiplexing mechanism to isolate applications. Existing composable systems that support two-level scheduling are restricted to cooperative intra-application schedulers, and thus cannot execute the time-triggered applications. In this work, we introduce a framework that allows concurrent, composable execution of such applications on temporally-partitioned systems. The framework is composed of an execution platform and a method for timing analysis of applications running on the platform. The platform realizes a software-based timed-interrupt virtualization technique on an existing composable system. Multiple time-triggered applications may run concurrently using different intra-application preemptive scheduling policies, e.g., fixed-priority and rate-monotonic. The analysis method formalizes the available processing time for executing each application on a processor in order to enable schedulability tests for different policies. Finally, these concepts are demonstrated by executing a number of applications, first on an FPGA prototype and second on a Matlab simulation of the platform. The results indicate a composable and concurrent execution of multiple time-triggered applications using our proposed framework. Furthermore, the implementation of the technique has low cost in terms of memory footprint and execution overhead.
A phase-shifted zero voltage transition full-bridge converter with current doubler synchronous rectification (2004)

This paper presents a phase-shifted ZVT full-bridge converter with current doubler synchronous rectification for commercial aircraft power systems. The detailed operating principle and design consideration of this soft-switched power converter are analyzed and described. Novel circuit topology and control scheme are proposed to exhibit optimum performances (i.e. high conversion efficiency, ring-free and low EMI features). A laboratory prototype, 500 W 5 V/100 A converter was implemented. The simulation and experimental waveforms verify the feasibility of the proposed design.
Impact of Sublingual Immunotherapy on Specific Antibody Levels in Asthmatic Children Allergic to House Dust Mites (2005)

SLIT seems to be effective in ameliorating clinical symptoms, drug consumption and bronchial hyperreactivity, and results in downregulation of Der-p-1-specific IgE production. Furthermore, at the end of SLIT, specific IgA levels, which were decreased compared to healthy controls initially, did no longer differ between patients and controls.
Stem cell-derived Sca-1<sup>+</sup> progenitors differentiate into smooth muscle cells, which is mediated by collagen IV-integrin α<sub>1</sub>/β<sub>1</sub>/α<sub>v</sub> and PDGF receptor pathways (2006)

Embryonic stem (ES) cells can differentiate into smooth muscle cells (SMCs) that can be used for tissue engineering and repair of damaged organs. However, little is known about the molecular mechanisms of differentiation in these cells. In the present study, we found collagen IV can promote ES cells to differentiate into stem cell antigen-1-positive (Sca-1(+)) progenitor cells and SMCs. Pretreatment of ES cells with antibodies against collagen IV significantly inhibited SMC marker expression. To further elucidate the effect of collagen IV on the induction and maintenance of SMC differentiation, Sca-1(+) progenitor cells were isolated with magnetic beads, placed in collagen-IV-coated flasks, and cultured in differentiation medium with or without platelet-derived growth factor (PDGF)-BB for 6-90 days. Both immunostaining and fluorescence-activated cell sorter analyses revealed that the majority of these cells were positive for SMC-specific markers. Pretreatment of Sca-1(+) progenitors with antibodies against integrin alpha(1), alpha(v), and beta(1), but not beta(3), inhibited focal adhesion kinase (FAK) and paxillin phosphorylation and resulted in a marked inhibition of SMC differentiation. Various tyrosine kinase inhibitors, and specific siRNA for phosphatidylinositol 3-kinase (PI 3-kinase) and PDGF receptor-beta significantly inhibited SMC marker expression. Taken together, we demonstrate for the first time that collagen IV plays a crucial role in the early stage of SMC differentiation and that integrin (alpha(1), beta(1), and alpha(v))-FAK-PI 3-kinase-mitogen-activated protein kinase and PDGF receptor-beta signaling pathways are involved in SMC differentiation.
Binary Heterogeneous Superlattices Assembled from Quantum Dots and Gold Nanoparticles with DNA (2011)

Controllable assembly of three-dimensional (3D) superlattices composed of different types of nanoscale objects opens new opportunities for material fabrication. Herein we show the successful assembly of heterogeneous 3D structures from gold nanoparticles (AuNPs) and quantum dots (QDs) using DNA encoding. By applying synchrotron-based small-angle X-ray scattering, we found that AuNPs and QDs are positioned in a body-centered cubic lattice, while each particle type, AuNP and QD, is arranged in a simple-cubic manner. Our studies demonstrate a route for assembly of integrated heterogeneous 3D structures from different nano-objects by DNA-encoded interactions.
Lithium Polymer Battery (2003)

This report focuses on the development of a lithium-ion conducting channel as a solid-state electrolyte for rechargeable lithium batteries. Dilithium phthalocyanine (Li2Pc) has been used in this development since it can undergo molecular self-assembly to form the ionically conducting channel. The essential features of the channel are that it is designed such that the anion matrix of the unsaturated macrocycle forms the channel through which the lithium ion moves, thus making it a single-ion conductor for lithium ions; the ionic transport of lithium depends on the electric field gradient created by the electrodes, thereby minimizing temperature for ionic transport.
Synthesis and biological response of some 3-iminoprogestins (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and biological response of some 3-iminoprogestinsArvin P. Shroff, R. P. Blyte, and J. L. McGuireCite this: J. Med. Chem. 1971, 14, 8, 769–770Publication Date (Print):August 1, 1971Publication History Published online1 May 2002Published inissue 1 August 1971https://pubs.acs.org/doi/10.1021/jm00290a023https://doi.org/10.1021/jm00290a023research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Suprameatal Extension of the Retrosigmoid Approach: Microsurgical Anatomy (1999)

The suprameatal extension of the retrosigmoid approach will permit removal of some tumors that are located mainly in the posterior fossa but that extend into the middle fossa in the region of Meckel's cave. The exposure can be increased by opening the superior petrosal sinus as it crosses in the upper margin of the porus of Meckel's cave and by opening the tentorium lateral to Meckel's cave.
Usefulness of continuous positive airway pressure in differential diagnosis of cardiac from pulmonary cyanosis in newborn infants. (1978)

Differential diagnosis of cyanosis in the neonate is difficult and cardiac catheterisation may be required for a correct diagnosis. It has been suggested that the response of PaO2 to continuous positive airway pressure (CPAP) with 100% oxygen may be useful. The purpose of this study was to test further this hypothesis by studying all neonates investigated for cyanosis with a PaO2 less than or equal to 50 torr in 0-8 to 1-0 F1O2. Arterial blood samples were obtained in an F1O2 of 0-21-0-4 and 0-8-1-0, and in an F1O2 of 0-8-1-0 with 8-10 cm CPAP, and were analysed for PaO2, PaCO2, and pH, bicarbonate being calculated. The final diagnoses were congenital heart disease (CHD) 21 cases, pulmonary parenchymal disease (PD) 10 cases, and persistent fetal circulation (PFC) 3 cases. No significant difference in pH, bicarbonate, or PaCO2 was observed among the three groups or with CPAP. In the CHD and PFC infants CPAP produced no significant change in PaO2. In the PD babies PaO2 increased by an average of 33 torr (P less than 0-05). Despite thus attaining statistical significance 2 PD infants had no increase in PaO2 with CPAP. An increase of PaO2 greater than 10 torr with CPAP suggests PD, and a nonsignificant increase in PaO2 does not rule out PD. Irrespective of initial PaO2, final PaO2 in 0-8-1-0 F1O2 with CPAP greater than 50 torr suggests PD, and less than 50 torr suggests CHD. The results indicate that CPAP may be used as an adjunct in differentiating cardiac from pulmonary disease.
MonPaaS: An Adaptive Monitoring Platformas a Service for Cloud Computing Infrastructures and Services (2014)

This paper presents a novel monitoring architecture addressed to the cloud provider and the cloud consumers. This architecture offers a monitoring platform-as-a-Service to each cloud consumer that allows to customize the monitoring metrics. The cloud provider sees a complete overview of the infrastructure whereas the cloud consumer sees automatically her cloud resources and can define other resources or services to be monitored. This is accomplished by means of an adaptive distributed monitoring architecture automatically deployed in the cloud infrastructure. This architecture has been implemented and released under GPL license to the community as “MonPaaS”, open source software for integrating Nagios and OpenStack. An intensive empirical evaluation of performance and scalability have been done using a real deployment of a cloud computing infrastructure in which more than 3,700 VMs have been executed.
Studies on radiation breeding in the genus Mentha. VI. Dose-response curve for root growth and interspecific difference in radiosensitivity. (1970)

ハッカの異なる種の乾燥種子に種々の線盤のγ線(60Co)を照射し後直ちに,これをペトリ皿上に播種して発根をうながし,20日後の種子根長に対する照射効果を調べた結果,根長抑制程度に著しい種間差異が認められた. また,その線量反応曲線は次の関数できわめてよく近似できることがわかった. Ar=1-(1-e-KD)4 ここにArは対照区平均に対する比で示した各線量区の根長平均,Dは線量,そしてKは種に固有の定数である. 種の放射線感受性は線量に関係なく,このKの値だけで表示でき,かつ表示された値は厳密に盤的な意味をもつ. 20の種あるいは系統について放射線感受性を推定した結果,最大約4倍の種間差異が見られ,また,ハッカ属の第1亜属と第2亜属間で感受性の分布が異なっていた. 線量反応曲線の型から感受性の種間差異の機構について若干の考察を試みた。
Micromachine-based fault-tolerant high resolution highspeed programmable fiber-optic attenuator (2002)

A programmable fiber-optic attenuator using a small tilt micromirror device is introduced, featuring digital control, alignment tolerance, and high speed, with a measured 37.8 dB optical attenuation and a 11-bit resolution.
Adaptive bidding for display advertising (2009)

Motivated by the emergence of auction-based marketplaces for display ads such as the Right Media Exchange, we study the design of a bidding agent that implements a display advertising campaign by bidding in such a marketplace. The bidding agent must acquire a given number of impressions with a given target spend, when the highest external bid in the marketplace is drawn from an unknown distribution P. The quantity and spend constraints arise from the fact that display ads are usually sold on a CPM basis. We consider both the full information setting, where the winning price in each auction is announced publicly, and the partially observable setting where only the winner obtains information about the distribution; these differ in the penalty incurred by the agent while attempting to learn the distribution. We provide algorithms for both settings, and prove performance guarantees using bounds on uniform closeness from statistics, and techniques from online learning. We experimentally evaluate these algorithms: both algorithms perform very well with respect to both target quantity and spend; further, our algorithm for the partially observable case performs nearly as well as that for the fully observable setting despite the higher penalty incurred during learning.
Les aventures de la Verkehrung (2005)

Résumé Par rapport au « renversement » qui, comme dans la dialectique, s’opère entre deux choses ayant le même niveau de substantialité, l’ « inversion » fonde une ontologie paradoxale où les choses à inverser ne préexistent pas à l’inversion elle-même. Tel est le sens d’une thèse ontologique largement partagée dans le marxisme d’aujourd’hui : le primat de la lutte de classes sur les classes. Tout en discernant nettement la différence du renversement et de l’inversion dans Le Capital , Jacques Rancière ne cesse de poser la question de savoir si le clivage des deux opérations est possible sans recours au « kautskisme » qui l’introduit dans la lutte de l’extérieur de la lutte, ce qui dénie purement et simplement le primat ontologique de la lutte. La solution donnée par lui est inouïe : radicalisant d’un côté l’inversion en tant que politique identique à la subjectivation, dans laquelle il n’y a plus de « constitué », et restituant de l’autre le renversement en tant qu’activité de l’imagination qui se différencie perpétuellement de soi comme dans le « rêve ouvrier » ou la « parole hérétique », il fait de ces deux opérations les conditions réciproques pour que l’une et l’autre viennent au jour.
A RE-EVALUATION OF THE OSTEOARTICULAR MANIFESTATIONS OF PSORIASIS (1991)

A distinctive peripheral arthropathy associated with psoriasis is well recognized, the classical pattern describing an asymmetrical oligoarthritis with predominant distal interphalangeal joint (DIP) involvement. There is some dispute about the frequency of this classical pattern and of the pattern of symmetrical polyarthritis resembling rheumatoid arthritis. Some of the dispute may be a result of loose definitions. In this clinical and scintigraphic study of 50 patients with psoriatic arthritis we have used tighter definitions of disease pattern and have found that 68% of this group had a symmetrical polyarthritis similar to that found in rheumatoid arthritis. Yet, arthritis associated with psoriasis differs from rheumatoid arthritis in a number of ways including the pattern of joint involvement, extra-articular osseous features, and radiological changes. Scintigraphic changes in psoriatic arthritis suggest that subclinical involvement of the manubriosternal and sternoclavicular joints is common, suggesting an association between psoriasis vulgaris and arthro-osteitis. A modified classification of the osteoarticular manifestations of psoriasis is proposed.
A Computer Aided System to Improve Dimensional Control of on-Site Construction (2003)

A Computer Aided System to Improve Dimensional Control of on-Site Construction Rui Wu, Ger Maas Pages 277-283 (2003 Proceedings of the 20th ISARC, Eindhoven, Holland, ISBN 978-90-6814-574-8, ISSN 2413-5844) Abstract: The increased use of prefabricated components, the complexity of new building shapes, and the speeding up of production in construction, demand an efficient and precise dimensional control. Meanwhile Information and Communication Technology (ICT) increasingly supports construction, among others, CAD systems and Total Stations, are being used for the purpose of dimensional control. In order to improve the dimensional control of on-site construction projects, this research tries to capture the knowledge required to design an adequate dimensional control plan and make that knowledge more generally available, and build a connection between CAD systems and Total Stations by applying state-of art ICT, focusing on prefabricated concrete building structural elements. This paper presents an updated information model that defines the various deviations and represents engineering experience knowledge using UML. The model has been implemented in a Dimensional Control System (DCS) and applied in the La Tour construction project in Apeldoorn, the Netherlands. Keywords: CAD Systems, Dimensional Control, Prefabricated Concrete, Total Stations, UML DOI: https://doi.org/10.22260/ISARC2003/0048 Download fulltext Download BibTex Download Endnote (RIS) TeX Import to Mendeley