gebhart/patrepeval huggingface dataset:
Reversible Downregulation of Protein Kinase A during Olfactory Learning Using Antisense Technique Impairs Long-Term Memory Formation in the Honeybee,<i>Apis mellifera</i> (1999)

In this study, we examined the role of cAMP-dependent protein kinase (PKA) in associative olfactory learning of the honeybee, Apis mellifera. In the bee, specific interference with molecules to clarify their role in a certain behavior is difficult, because genetic approaches, such as mutants or transgenic animals, are not feasible at the moment. As a new approach in insects in vivo, we report the use of short antisense oligonucleotides. We show that phosphorothioate-modified oligodeoxynucleotides complementary to the mRNA of a catalytic subunit of PKA directly injected into the bee brain cause a reversible and specific downregulation of both the amount of the catalytic subunit and of PKA activity by 10-15%. The amounts of the regulatory subunit of PKA, as well as PKC, are not affected. The slight "knockdown" of PKA activity during the training procedure, a classical olfactory conditioning of the proboscis extension reflex, neither affects acquisition nor memory retention 3 or 6 hr after training. However, it causes an impairment of long-term memory retention 24 hr after training. Downregulation of PKA 3 hr after training has no detectable effect on memory formation. We conclude that PKA contributes to the induction of a long-term memory 24 hr after training when activated during learning. Second, we demonstrate that the antisense technique is feasible in honeybees in vivo and provides a new and powerful tool for the study of the molecular basis of learning and memory formation in insects.
Progress in electronics (1981)

Electronics Update '80, Institute of Physics (Electronics Group), 28 October 1980 at the Institution of Mechanical Engineers, London.
Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms (2014)

Huntington's disease (HD) is a neurodegenerative disorder that is best known for its effect on motor control. Mood disturbances such as depression, anxiety, and irritability also have a high prevalence in patients with HD, and often start before the onset of motor symptoms. Various rodent models of HD recapitulate the anxiety/depressive behavior seen in patients. HD is caused by an expanded polyglutamine stretch in the N-terminal part of a 350 kDa protein called huntingtin (HTT). HTT is ubiquitously expressed and is implicated in several cellular functions including control of transcription, vesicular trafficking, ciliogenesis, and mitosis. This review summarizes progress in efforts to understand the cellular and molecular mechanisms underlying behavioral disorders in patients with HD. Dysfunctional HTT affects cellular pathways that are involved in mood disorders or in the response to antidepressants, including BDNF/TrkB and serotonergic signaling. Moreover, HTT affects adult hippocampal neurogenesis, a physiological phenomenon that is implicated in some of the behavioral effects of antidepressants and is linked to the control of anxiety. These findings are consistent with the emerging role of wild-type HTT as a crucial component of neuronal development and physiology. Thus, the pathogenic polyQ expansion in HTT could lead to mood disorders not only by the gain of a new toxic function but also by the perturbation of its normal function.
Low-melting zwitterion: effect of oxyethylene units on thermal properties and conductivity (2010)

An imidazolium-based zwitterion containing two oxyethylene units was obtained as a colorless liquid at room temperature. The equimolar mixture of the liquid zwitterion and lithium bis(trifluoromethylsulfonyl)amide showed an ionic conductivity of over 10(-4) S cm(-1) at 80 °C, which was higher than those of mixtures composed of analogous solid zwitterions.
The road to business process improvement--can you get there from here? (1995)

Historically, "improvements" within the organization have been frequently attained through automation by building and installing computer systems. Material requirements planning (MRP), manufacturing resource planning II (MRP II), just-in-time (JIT), computer aided design (CAD), computer aided manufacturing (CAM), electronic data interchange (EDI), and various other TLAs (three-letter acronyms) have been used as the methods to attain business objectives. But most companies have found that installing computer software, cleaning up their data, and providing every employee with training on how to best use the systems have not resulted in the level of business improvements needed. The software systems have simply made management around the problems easier but did little to solve the basic problems. The missing element in the efforts to improve the performance of the organization has been a shift in focus from individual department improvements to cross-organizational business process improvements. This article describes how the Electric Boat Division of General Dynamics Corporation, in conjunction with the Data Systems Division, moved its focus from one of vertical organizational processes to horizontal business processes. In other words, how we got rid of the dinosaurs.
Modeling from reality (2002)

This paper presents an overview of our efforts in modeling-from-realty to create virtual reality models through observation of real objects. These efforts span three aspects: how to create geometric models of virtual objects; how to create photometric models of virtual objects; and how to integrate such virtual objects with real scenes. For geometric model creation, we have developed a two-step method: simultaneous alignment and volumetric view merging. For photometric model creation, we have developed two methods, model-based and eigen-texture rendering methods, both of which automatically create models by observing the real objects. For the integration of virtual objects with real scenes, we have developed a method that renders virtual objects based on real illumination distribution. We have successfully tested the proposed methods by using real images to demonstrate their effectiveness.
Selected Grass Plants as Biomass Fuels and Raw Materials for Papermaking, Part II. Pulp and Paper Properties (2015)

The yield and kappa number of kraft pulps from tall wheatgrass, tall fescue, tall oatgrass, and Miscanthus were determined after pulping with 0.9% active alkali per 1% lignin content in raw materials. Fibre properties and test papers were also studied to evaluate the usefulness of these plants for papermaking. These results were compared with pulps prepared from birch and pine wood. Kraft pulps from the straws of grasses had yields similar to that of pulp from pine wood and lower kappa numbers than pulps from birch and pine wood. The tested pulps exhibited a favourable number of fibres in 1 g of pulp, and they resulted in papers with clearly differentiated properties from very resistant to rupture dense papers with very low air permeability, to less resistant to breaking more bulky papers.
A slot interleaved multiple access scheme for DQDB metropolitan area networks (2002)

A slot interleaved multiple access (SIMA) scheme for distributed-queue dual-bus (DQDB) metropolitan area networks is proposed. In this scheme, all the active nodes will access the slots in an interleaved fashion. This scheme is very efficient for solving the bandwidth domination problem and the priority domination problem, which cannot be solved readily by the DQDB medium access control (MAC) protocol with a bandwidth balancing mechanism. An enhanced SIMA (ESIMA) scheme is proposed to solve the bandwidth allocation problem, which cannot be solved by the DQDB MAC protocol. Simulation results show that SIMA and ESIMA perform much better than the DQDB MAC on throughput as well as the access delay.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pasting and Identification of Starches (1940)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTPasting and Identification of StarchesWillard L. MorganCite this: Ind. Eng. Chem. Anal. Ed. 1940, 12, 6, 313–317Publication Date (Print):June 1, 1940Publication History Published online1 May 2002Published inissue 1 June 1940https://pubs.acs.org/doi/10.1021/ac50146a001https://doi.org/10.1021/ac50146a001research-articleACS PublicationsRequest reuse permissionsArticle Views395Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Copper particles/epoxy resin thermosetting conductive adhesive using polyamide resin as curing agent (2012)

Abstract Thermosetting conductive adhesive (TCA) comprised of epoxy resin E‐51 as matrix, Cu microparticles and nanoparticles modified by silane coupling KH550 as conductive fillers, polyamide resin with low molecular weight as curing agent, and some other additives. It was reported creatively a new liquid curing agent, which solved successfully some difficult problems during preparation of TCA, such as limit of quantity of conductive fillers. Therefore, application of this liquid curing agent decreased greatly the resistivity of TCA under the condition of keeping enough adhesion strength. Antioxidized and mixed Cu particles were developed as conductive fillers in place of expensive Ag. The results showed that optimum conditions of conductive adhesive composed of 16 wt % of epoxy resin E‐51, 8 wt % polyamide resin, 65 wt % of Cu microparticles and nanoparticles, 1.3 wt % of silane coupling agent, and 9 wt % of other additives with curing time for 4 h at 60°C. The adhesion strength reached 16.7 MPa and the bulk resistivity was lower than 3.7 × 10 −4 Ω cm. The variation of bulk resistivity was less than 15% at high temperature (100°C). © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Optical Differentiation Wavefront Sensing for Astronomy and Vision Applications (2016)

An optical differentiation wavefront sensor utilizing binary pixelated transmission filters is an inexpensive and high performance adaptive optics instrument. Simulated and experimental results that demonstrate its potential for astronomical and vision applications are presented.
Anatomic study of the lumbar lamina for safe and effective placement of lumbar translaminar facet screws (2019)

Objective To evaluate the anatomic characteristics of the lumbar lamina and suggest a safe and effective strategy for setting lumbar translaminar facet screws. Methods The width and length of the lumbar lamina, screw path, lateral angle of the lamina, and maximum and minimum caudal angles of the lamina from L3 to L5 were measured with Mimics software using 32 patients’ computed tomographic data. Results The optimal screw entry point was located at the median of the spinous process base or slightly lower. The ideal screw trajectory was from the entry point to the base of the transverse process and across the center of the facet joint. A length of 35 to 45 mm was suitable for L3 to L4 in most cases, and a length of 45 to 50 mm was safe for L5 in most cases. The screw should be inserted at an angle of 49.4° to 59.29° laterally and 43.68° to 57.58° caudally at L3 to L5. For the ideal caudal angle, error of <3° was considered safe. Conclusion The optimal entry point, ideal screw trajectory, ideal screw-setting angles, and safest range of the angle and length of the lumbar lamina were identified in this anatomical study.
Electrophysical properties and structural features of shungite (natural nanostructured carbon) (2013)

This paper presents the results of investigations of the electrical conductive properties with a nanoscale locality at nanoampere currents and the results of an analysis of the correlation between the electrical conductivity and structural features of natural glassy carbon, i.e., shungite. The investigations have been performed using atomic force microscopy, electric force spectroscopy, scanning spreading resistance microscopy, X-ray spectroscopic analysis, and Raman spectroscopy. It has been found that there are differences in electrical conductive properties of the structurally similar shungite samples formed under different PT conditions. Based on the analysis of the structural parameters and specific features of the shungite compositions, it has been shown that the effect of intercalation of impurities into boundary layers of graphene sheets has the most significant influence on the electrical and physical properties of the shungites. The differences in types and values of conductivity of the shungite samples are determined by the different degrees of intercalation.
Antisense epidermal growth factor receptor transfection impairs the proliferative ability of human rhabdomyosarcoma cells. (1996)

Human rhabdomyosarcoma cells express membrane epidermal growth factor receptor (ECF-R), which could confer responsiveness to EGF and transforming growth factor-alpha (TGF-alpha) of autocrine or paracrine origin. To study the role played by this growth factor circuit in the proliferation and differentiation of myogenic neoplastic cells, human rhabdomyosarcoma EGF-R-expressing cells (RD/18 clone) have been transfected with a plasmid containing a fragment of the EGF-R cDNA in the antisense orientation. In vitro growth and differentiative ability were studied on six antisense-transfected clones (AS) in comparison to parental RD/18 cells and to cells transfected with the plasmid containing only the neomycin resistance gene (NEO). A reduced EGF-R membrane expression was found in AS clones by decreased immunofluorescence with an anti-EGF-R monoclonal antibody. All AS transfectants had a greatly impaired proliferative ability, even when cultured in fetal bovine serum-containing medium. Proliferation of AS clones was completely blocked in medium supplemented with 2% horse serum. The differentiation ability of AS clones was heterogeneous, ranging from clones with a percentage of myosin-positive cells higher than controls to clones with a negligible myosin expression. Therefore, the growth impairment determined by the loop interruption is not sufficient to switch on the differentiation program. The role played by EGF-R in the proliferation of human rhabdomyosarcoma cells suggests that this receptor could constitute a target for a therapeutic approach.
Low-Energy E-Beam Proximity Lithography (LEEPL): Is the Simplest the Best? (1999)

Low-energy e-beam proximity lithography (LEEPL) is proposed as the simplest integrated circuit lithography for minimum feature sizes ≤0.1 µm. This new e-beam lithography is similar to 1× X-ray proximity lithography except that the X-ray beam is replaced with a beam of low-energy electrons of 2 kV. This low e-beam energy permits the use of single-crystal 0.5-µm-thick silicon stencil masks without an absorbing metal layer of high atomic number. This membrane mask is thick enough for good heat conduction and thin enough for feature sizes ≤0.1 µm. Mask distortion caused by fabrication can be corrected by a fine-tuning deflector. Therefore, a mask with a residual distortion of more than 100 nm is acceptable. This eliminates the main difficulty of X-ray proximity lithography. The proposed system is not affected by a space-charge effect in the electron optics column, and a proximity effect with respect to both wafer and mask writings, and it is fundamentally low-power lithography which needs no special cooling system. The analysis shows that the e-beam column can be made entirely of electrostatic components to achieve sufficient resolution. For an appropriate resist process for this low-energy e-beam, we propose a bilayer process such as the chemical amplification of resist lines (CARL) process which consists of a chemically amplified thin deep ultraviolet (DUV) photoresist and a thick planarizing layer as a starting point. We estimated a throughput of about 40 12 inch wafers per hour and a resolution of a significantly less than 50 nm.
Concepts, Issues, and Standards. Standards for Medical Hardware, Software, and Information Exchange: Standard and Non-Standardized Data Bases in Long Term Care (1990)

The Resource Utilization Groups (RUG-II), a case mix payment system for long term care facilities in New York State, is a highly structured and standardized data base. By mandating the electronic submission of data elements, the RUG-II forced computerization of nursing homes. As this data base has to be maintained, we visualized it as the core to which other data bases could be related. Examination of Federal and State mandate functions which regulate nursing homes identified a series of data bases that ranged from being structured and standardized to being unstructured. The data bases in these functions are open to computerization and can be related to the RUG-II clinical data for research, administrative and quality assurance purposes.
Talking to Godot: dialogue with a mobile robot (2003)

Godot is a mobile robot platform that serves as a testbed for the interface between a sophisticated low-level robot navigation and a symbolic high-level spoken dialogue system. The interesting feature of this combined system is that information flows in two directions: (1) the navigation system. supplies landmark; information from the cognitive map used for the interpretation of the user's utterances in the dialogue system; and (2) the semantic content of utterances analysed by the dialogue system are used to adjust probabilities about the robot's position in the navigation system.
Advances in Materials for Recent Low-Profile Implantable Bioelectronics (2018)

The rapid development of micro/nanofabrication technologies to engineer a variety of materials has enabled new types of bioelectronics for health monitoring and disease diagnostics. In this review, we summarize widely used electronic materials in recent low-profile implantable systems, including traditional metals and semiconductors, soft polymers, biodegradable metals, and organic materials. Silicon-based compounds have represented the traditional materials in medical devices, due to the fully established fabrication processes. Examples include miniaturized sensors for monitoring intraocular pressure and blood pressure, which are designed in an ultra-thin diaphragm to react with the applied pressure. These sensors are integrated into rigid circuits and multiple modules; this brings challenges regarding the fundamental material's property mismatch with the targeted human tissues, which are intrinsically soft. Therefore, many polymeric materials have been investigated for hybrid integration with well-characterized functional materials such as silicon membranes and metal interconnects, which enable soft implantable bioelectronics. The most recent trend in implantable systems uses transient materials that naturally dissolve in body fluid after a programmed lifetime. Such biodegradable metallic materials are advantageous in the design of electronics due to their proven electrical properties. Collectively, this review delivers the development history of materials in implantable devices, while introducing new bioelectronics based on bioresorbable materials with multiple functionalities.
Pulmonary Aspergilloma (1964)

EXCEPT for pulmonary resection in selected cases, the therapy of pulmonary aspergillosis has been generally ineffective. Nevertheless, in isolated cases, cures have followed the administration of nystatin by mouth1 and by aerosol2 and the parenteral injection of stilbamidine.3 More recently, the administration of 24 to 30 gm. of potassium iodide by mouth in 2 cases4 and of amphotericin B intravenously in another5 was also thought to be therapeutically effective. However, the drug intolerance and electrolyte imbalance resulting from large doses of iodides taken by mouth4 and the systemic and renal toxic effects of intravenously administered amphotericin6 , 7 prevent a casual approach . . .
Effects of feedback and peer pressure on contributions to enterprise social media (2009)

http://www.aaai.org/Press/Reports/Symposia/Spring/ss-09-04.php
Deciding Which Queue to Join: Some Counterexamples (1986)

Consider a queueing system with two or more servers, each with its own queue with infinite capacity. Customers arrive according to some stochastic process (e.g., a Poisson process) and immediately upon arrival must join one of the queues, thereafter to be served on a first-come first-served basis, with no jockeying or defections allowed. The service times are independent and identically distributed with a known distribution. Moreover, the service times are independent of the arrival process and the customer decisions. The only information about the history of the system available for deciding which queue to join is the number of customers currently waiting and being served at each server. Joining the shortest queue is known to minimize each customer's individual expected delay and the long-run average delay per customer when the service-time distribution is exponential or has nondecreasing failure rate. We show that there are service-time distributions for which it is not optimal to always join the shortest queue. We also show that if, in addition, the elapsed service times of customers in service are known, the long-run average delay is not always minimized by customers joining the queue that minimizes their individual expected delays.