gebhart/patrepeval huggingface dataset:
The Clinical Efficacy of the Repeated Transcervical Instillation of Quinacrine for Female Sterilization (1976)

Zipper, J., Medel, M., Goldsmith, A., Edelman, D., Pastene, L. and Rivera, M. (Dept. of Physiology & Biophysics, School of Medicine, University of Chile, Santiago, and Dept. of Obstetrics & Gynecology, Hospital Sotero del Rio, Puente Alto, Chile, and International Fertility Research Program, Research Triangle Park, North Carolina 27709, USA). The clinical efficacy of the repeated transcervical instillation of quinacrine for female sterilization . Int J Gynaecol Obstet 14 :499–502, 1976. The safety and efficacy of the repeated transcervical instillation of quinacrine hydrochloride in a suspension of 5 ml of 2% Xylocaine was evaluated in 200 patients. All instillation procedures were performed during the proliferative phase of the menstrual cycle: the second instillation was made in the first menstrual cycle following the initial instillation and the third and last instillation at 6 months after the first. None of the patients used any adjunctive contraceptives. Follow‐up visits were scheduled at 6‐month intervals after the last instillation. The potentially serious complications following the instillation were four cases of cortical exitation, and one case of acute adnexitis. The second instillation was not performed for 16.0% and the third instillation was not performed for 16.7% of the patients, for medical and/or personal reasons. Fifty‐one pregnancies were reported, 41 (80.4%) before completion of the three instillations. The results of this study show that the instillation schedule used is unsatisfactory for widespread use. Additional studies are currently being conducted to evaluate the use of an adjunctive contraceptive up to the time of the third instillation in order to reduce the high pregnancy rate.
PERFECTLY MATCHED LAYERS FOR ELASTODYNAMICS: A NEW ABSORBING BOUNDARY CONDITION (1996)

The use of perfectly matched layers (PML) has recently been introduced by Berenger as a material absorbing boundary condition (ABC) for electromagnetic waves. In this paper, we will first prove that a fictitious elastodynamic material half-space exists that will absorb an incident wave for all angles and all frequencies. Moreover, the wave is attenuative in the second half-space. As a consequence, layers of such material could be designed at the edge of a computer simulation region to absorb outgoing waves. Since this is a material ABC, only one set of computer codes is needed to simulate an open region. Hence, it is easy to parallelize such codes on multiprocessor computers. For instance, it is easy to program massively parallel computers on the SIMD (single instruction multiple data) mode for such codes. We will show two- and three-dimensional computer simulations of the PML for the linearized equations of elastodynamics. Comparison with Liao’s ABC will be given.
Upgrading heavy oil using slurry processes (1995)

There is a growing interest in processes capable of converting heavy feedstocks (petroleum residues and heavy oils) into lower boiling products of high quality. The operational problems of upgrading heavy feeds relate to the presence of sulfur, nitrogen, metals, and considerable amounts of Conradson carbon residue. An efficient residue conversion process must be able to reduce the molecular weight of the feedstocks to material with boiling points below 550 C, increase the H-to-C ratio of the refined product, and remove heteroatoms and metals. Whereas the molecular weight reduction is normally achieved by C-C bond cracking above 400 C, often in the presence of acid catalysts, a higher H-to-C ratio can be obtained by either the rejection of carbon (as in coking) or the addition of hydrogen (as in hydrogenation processes). Slurry processes combine the flexibility of the carbon rejection with the high performance of the hydrogen addition processes. The origin of slurry processes is the Bergius-Pier technology (1920--1930) for the conversion of heavy oils and coal into distillates. Whereas the original Bergius-Pier technology did not use a catalyst, small amounts of inexpensive additives or finely dispersed hydrogenation catalysts can be used to increase the rates of the desired reactions. Catalystsmore » can also inhibit coke formation by physically interfering with the coalescence of mesophase, which is the precursor of solid coke. Catalysts are used to reduce the severity of the process and to improve the quality of the products. Most of the research carried out in the past decade in the field of slurry processes has dealt with the identification of more effective and/or less expensive catalysts and the technological problems related to their use. Here the authors discuss both subjects, describing the path from the fundamental chemistry of dispersed catalytic systems to the development and initial commercialization of slurry processes.« less
Insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase (1998)

The pathways involved in the cellular responses to the insulin-like growth factors (IGFs) are numerous and vary according to cell type. Following activation of the IGF-I receptor, the mitogen-activated protein kinase and phosphatidylinositide 3'-kinase (PI3'K) pathways are activated and result in cellular proliferation and inhibition of apoptosis. In this study, we analyzed the IGF-I effect on the stress-activated protein kinase/c-Jun N-terminal kinase (JNK) activity using human embryonic kidney 293 cells, 293 cells transiently expressing hemagglutinin-JNK, and 293 cells stably expressing a hemagglutinin-JNK transgene. In all cell types, endogenous or transfected JNK activity was strongly stimulated by anisomycin or tumor necrosis factor-alpha, and 10 nM IGF-I pretreatment suppressed the induced JNK activity. To determine whether the effect of IGF-I on JNK activity involves the mitogen-activated protein kinase or PI3'K pathway, we used the specific MEK1 inhibitor PD098059 and the PI3'K inhibitor LY 294002. PD098059 did not alter the IGF-I suppressive effect on stressor-induced JNK activity, but LY 294002 suppressed the IGF-I effect. Moreover, in transiently transfected parental 293 cells expressing dominant-negative Akt, anisomycin-increased JNK activity was not suppressed by pretreatment with IGF-I. Our results demonstrate that the action of IGF-I on JNK in these cells is via PI3'K and Akt.
Exploring Design Challenges in Getting Solid State Drives Closer to CPU (2014)

The PCI Express Solid State Drives (PCIe SSDs) blur the difference between block and memory access semantic devices. Since these SSDs leverage PCIe bus as their storage interface, their interfaces are different from conventional memory system interconnects, as well as from standard storage interfaces. This leads to a new SSD architecture and storage software stack design. Unfortunately, there are not ample studies focusing on the system-level characteristics and the power consumption behaviors behind these emerging PCIe SSD platforms. In this paper, we quantitatively analyze the challenges faced by PCIe SSDs in getting flash memory closer to CPU, and study two representative PCIe SSD architectures (from-scratch SSD and bridge-based SSD) using state-of-the-art real SSDs with our in-house resource analyzer and dynamic evaluation platform. Our experimental analysis reveals that 1) while the from-scratch SSD approach offers remarkable performance improvements, it requires enormous host-side memory and computational resources; 2) the performance of the from-scratch SSD significantly degrades in a multi-core system; 3) bridge-based SSD architecture has a potential to improve performance by co-optimizing their flash software and controllers; 4) PCIe SSDs' latencies significantly degrade with their storage-level queueing mechanism; 5) tested PCIe SSDs consume 200 $\sim$ 500 percent more dynamic power than a conventional SSD; and 6) the power consumption increases by 33 percent, on average, when PCIe SSDs suffer from the performance drops caused by garbage collections. While our analytical study using the commercially available PCIe SSD products can include technical conjecture and inference, the findings and the empirical evidences present many design challenges that the future architecture and software stack probably need to address.
Synthesis and structure-activity relationships among .alpha.-adrenergic receptor agonists of the phenylethanolamine type (1980)

Nineteen arylethanolamine derivatives related to norepinephrine were prepared and tested for alpha-adrenergic stimulant activity. In one series the analogues possess a p-hydroxy function, while the meta position is substituted by methyl, ethyl, isopropyl, chlohexyl, fluoro, chloro, iodo, carboxy, carbomethoxy, and methylsulfamido groups. The other series is meta hydroxylated with the para position substituted by the same groups. The influence of these groups upon the alpha-adrenergic activity is discussed, and the compounds are compared to octopamine, normetanephrine, norepinephrine, and norphenylephrine. It has been found that the introduction of an isopropyl, cyclohexyl, and fluoro group in the meta position of octopamine improves its affinity by three, five, and six times, respectively, whereas when these groups are introduced in the para position of norphenylephrine their effects are always detrimental. The most active compound, alpha-(aminomethyl)(4-fluoro-3-hydroxyphenyl)methanol (44), has about one-hundredth the affinity and the same intrinsic activity as norepinephrine.
A Comparison Between Measured and Modeled Residual Stresses in a Circumferentially Butt-Welded P91 Steel Pipe (2010)

Residual macrostresses in a multipass circumferentially butt-welded P91 ferritic steel pipe have been determined numerically and experimentally. The welded joint in a pipe with an outer diameter of 290 mm and a wall thickness of 55 mm is typical of power generation plant components. An axisymmetric thermomechanical finite element model has been used to predict the resulting residual hoop and axial stresses in the welded pipe. The effects of the austenite to martensite phase transformation have been incorporated into the simulation. Residual stresses have been measured using the X-ray diffraction technique along the outer surface of the pipe and using the deep-hole drilling technique through the wall thickness at the center of the weld. Good correlation has been demonstrated between the residual hoop and the axial stresses obtained numerically and experimentally. The paper demonstrates the importance of using a mixed experimental and numerical approach to determine accurately the residual macrostress distribution in welded components.
Adaptive Modulation Systems for Predicted Wireless Channels (2002)

When adaptive modulation is used to counter short-term fading in mobile radio channels, signaling delays create problems with outdated channel state information. The use of channel power prediction will improve the performance of the link adaptation. It is then of interest to take the quality of these predictions into account explicitly when designing an adaptive modulation scheme. We study the optimum design of an adaptive modulation scheme based on uncoded M -quadrature amplitude modulation, assisted by channel prediction for the flat Rayleigh fading channel. The data rate, and in some variants the transmit power, are adapted to maximize the spectral efficiency, subject to average power and bit-error rate constraints. The key issues studied here are how a known prediction error variance will affect the optimized transmission properties, such as the signal-to-noise ratio (SNR) boundaries that determine when to apply different modulation rates, and to what extent it affects the spectral efficiency. This investigation is performed by analytical optimization of the link adaptation, using the statistical properties of a particular, but efficient, channel power predictor. Optimum solutions for the rate and transmit power are derived, based on the predicted SNR and the prediction error variance.
A distributed approach for access and visibility task with a manikin and a robot in a virtual reality environment (2003)

This paper presents a new method, based on a multi-agent system and on a digital mock-up technology, to assess an efficient path planner for a manikin or a robot for an access and visibility task taking into account ergonomic constraints or joint and mechanical limits. In order to solve this problem, the human operator is integrated in the process optimization to contribute to a global perception of the environment. This operator cooperates, in real time, with several automatic local elementary agents. The result of this work validates solutions through the digital mock-up; it can be applied to simulate maintainability and mountability tasks.
How controlled and versatile is N-carboxy anhydride (NCA) polymerization at 0 °C? Effect of temperature on homo-, block- and graft (co)polymerization (2010)

The polymerization of N-carboxyanhydride (NCA) at low temperatures is controlled and allows the synthesis of a variety of well-defined polypetides.
Influence of Speed and Step Frequency during Walking and Running on Motion Sensor Output (2007)

Increasing underestimation of activity by the ActiGraph as speed increases is related to frequency-dependent filtering and assessment of acceleration in the vertical plane only. RT3 vector magnitude was strongly related to speed, reflecting the predominance of horizontal acceleration at higher speeds. These results indicate that high-intensity activity is underestimated by the ActiGraph, even after correction for frequency-dependent filtering, but not by the RT3. Pedometer output is highly correlated with step frequency.
Chemical vapour deposition of amorphous Ru(P) thin films from Ru trialkylphosphite hydride complexes (2012)

The ruthenium phosphite hydride complexes H(2)Ru(P(OR)(3))(4) (R = Me (1), Et (2), (i)Pr (3)) were used as CVD precursors for the deposition of films of amorphous ruthenium-phosphorus alloys. The as-deposited films were X-ray amorphous and XPS analysis revealed that they were predominantly comprised of Ru and P in zero oxidation states. XPS analysis also showed the presence of small amounts of oxidized ruthenium and phosphorus. The composition of the films was found to depend on ligand chemistry as well as the deposition conditions. The use of H(2) as the carrier gas had the effect of increasing the relative concentrations of P and O for all films. Annealing films to 700 °C under vacuum produced films of polycrystalline hcp Ru while a flowing stream of H(2) resulted in polycrystalline hcp RuP.
Complaint: Hinsch December 2012 (2013)

COMPLAINT REGARDING INVENTION PROMOTERDATE OF CORRESPONDENCE: December 3, 2012Name of the Invention Promotion Company: Davison Corporation
Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2 (2015)

High throughput screening followed by a lead generation campaign uncovered a novel series of urea containing morpholinopyrimidine compounds which act as potent and selective dual inhibitors of mTORC1 and mTORC2. We describe the continued compound optimization campaign for this series, in particular focused on identifying compounds with improved cellular potency, improved aqueous solubility, and good stability in human hepatocyte incubations. Knowledge from empirical SAR investigations was combined with an understanding of the molecular interactions in the crystal lattice to improve both cellular potency and solubility, and the composite parameters of LLE and pIC50–pSolubility were used to assess compound quality and progress. Predictive models were employed to efficiently mine the attractive chemical space identified resulting in the discovery of 42 (AZD3147), an extremely potent and selective dual inhibitor of mTORC1 and mTORC2 with physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate.
Rearrangement of N<sub>α</sub>-Protected <scp>l</scp>-Asparagine with Iodosobenzene Diacetate. A Practical Route to β-Amino-<scp>l</scp>-alanine Derivatives (1998)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionRearrangement of Nα-Protected l-Asparagine with Iodosobenzene Diacetate. A Practical Route to β-Amino-l-alanine DerivativesLin-Hua Zhang, Goss S. Kauffman, Jaan A. Pesti, and Jianguo YinCite this: J. Org. Chem. 1998, 63, 26, 10085Publication Date (Web):December 3, 1998Publication History Published online3 December 1998Published inissue 1 December 1998https://pubs.acs.org/doi/10.1021/jo984023whttps://doi.org/10.1021/jo984023wcorrectionACS PublicationsCopyright © 1998 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views634Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (32 KB) Get e-Alertsclose Get e-Alerts
Interaction of Herbs and Glibenclamide: A Review (2012)

Herbs and herbal products are considered to be safer and people mix it often with the oral hypoglycemic agent in diabetes therapy. But numerous reports say that every combination of herbs and drugs is not safe. Some combinations may be beneficial and some may be harmful also. So before taking any herbal remedies with oral hypoglycemic agent, patient should consult physician. In this paper we are summarizing the reports available on the interaction of herbal remedies to one of the oral hypoglycemic agents (glibenclamide) and categorizing the effect of the combination is beneficial and harmful.
Adjusting scrotal circumference of yearling beef bulls in five composites (1996)

Records from five composite strains of beef cattle were used to estimate age of dam and age of bull adjustment factors for scrotal circumference of yearling bulls. Data were obtained from Beefbooster Cattle Alberta Ltd., Calgary, AB. There were 5244 scrotal circumference records on yearling bulls born from 1987 to 1992. M1, M2, and M4 were maternal composites selected primarily for weaning weight, M3 was a terminal composite selected primarily for low birth weight, and TX was a terminal composite selected primarily for feedlot gain. The prominent foundation breeds were Angus for M1, Hereford for M2, various small breeds for M3, Limousin and Gelbvieh for M4, and Charolais for TX. Statistical analyses were performed for each composite separately according to the model that included the fixed effects of herd, year, age of dam and linear (quadratic was not significant) regression on age of bull at measurement. Average age at measurement was 340, 333, 361, 358, and 375 d for M1, M2, M3, M4, and TX, respectively, and range in age was about 100 d for most composites. Age of dam was significant for all composites except M4. Linear regressions on age of bull were 0.0376, 0.0379, 0.0308, 0.0410, and 0.0349 cm d −1 for M1, M2, M3, M4, and TX, respectively. Scrotal circumference of composite bulls should be adjusted additively for age of dam and linearly for age of bull. These adjustments tended to be smaller for age of dam and larger for age of bull than those reported for straighbred or purebred bulls. Key words: Beef cattle, composites, scrotal circumference, adjustment factors
Eine einfache Synthese von Tetramethylpyrrol (1965)

Abstract Das leicht zugängliche Dichlorid I gibt mit Ammoniak oder primären Aminen bei Raumtemperatur in glatter Reaktion Tetramethylpyrrol bzw. dessen N ‐Substitutionsprodukte. Weiterhin wurde I in eine Reihe ungesättigter Amine und Hydroxyamine des Cyclobutans verwandelt. Die Umsetzung von I mit Thioharnstoff oder Harnstoff führte zu bicyclischen Thiazolinen bzw. Oxazolinen.
Continuous Monitoring of Dynamic Pulmonary Compliance Enables Detection of Endobronchial Intubation in Infants and Children (2007)

Pulmonary compliance changes are a sensitive and an accurate indicator of endobronchial intubation in infants and children. Both increased peak airway pressures and changes in breath sounds are less sensitive indicators of endobronchial intubation.
Asymmetric synthesis catalyzed by transition-metal complexes with functionalized chiral ferrocenylphosphine ligands (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric synthesis catalyzed by transition-metal complexes with functionalized chiral ferrocenylphosphine ligandsTamio Hayashi and Makoto KumadaCite this: Acc. Chem. Res. 1982, 15, 12, 395–401Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/ar00084a003https://doi.org/10.1021/ar00084a003research-articleACS PublicationsRequest reuse permissionsArticle Views1669Altmetric-Citations277LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The automobile in 1997: Systems engineering promises integrated performance features, more luxuries, and advanced diagnostics (1987)

The author predicts what sophisticated cars will be like in ten years. The chief features are: (1) power-train controls that respond to the varying amounts of engine-torque demands by integrating response with driver input; (2) automatic electronic suspension control (active suspension) to improve both the ride and the handling; (3) electronic management of the car's electric-power system based on novel power-generating components and load-management controls; (4) traction control that combined power-train control and antilock braking; and (5) multipurpose switches and shared displays for driver information, climate control, and entertainment systems. The means by which these technological advances will be accomplished are examined.
Serum protein profiles as potential biomarkers for infectious disease status in pigs (2012)

This study shows that serum protein profiles have potential for detection and identification of viral infections in pigs before clinical signs of the disease become visible.