gebhart/patrepeval huggingface dataset:
Neurogenetic Analysis of Potassium Currents in Drosophila: Synergistic Effects on Neuromuscular Transmission in Double Mutants (1983)

Recombinational dissection of the ShrK0120 strain of Drosophila melanogaster demonstrated that its extremely prolonged neuromuscular transmission, a defect qualitatively different from other Sh alleles, results from a synergistic interaction with a second site mutation. This new mutation caused spontaneous repetitive firing in motor axons and increased transmitter release. Complementation tests showed that it is allelic to eag. Combining either eag allele with various Sh alleles reproduced the same extreme defect observed in the original ShrK0120 strain. Thus, from their effects on neuromuscular transmission no qualitative difference among Sh alleles is apparent while Sh, eag, and eag Sh double mutant individuals can be uniquely distinguished. Pharmacological experiments indicated that Sh affects a membrane component sensitive to the potassium channel blockers 4-AP and TEA while eag affects a component sensitive to TEA but not 4-AP. We suggest that eag and Sh preferentially disrupt different potassium currents explaining their synergistic interaction.
Computer simulation and measurement of error vector magnitude (EVM) and adjacent-channel power ratio (ACPR) for digital wireless communication RF power amplifiers (1999)

Computer simulation and measurement of the error vector magnitude (EVM) and the adjacent channel power ratio (ACPR) of a 2.4 GHz MMIC power amplifier (PA) for digital wireless communications is presented. A computer simulation based on the /spl pi//4-DQPSK modulation with square-root raised cosine (SRRC) filter is established for this study. Using digital signal processing techniques and a time-domain approach, we can accurately predict the EVM and the ACPR related to the input power. The nonlinear effects of the MMIC PA are modeled as traditional nonlinearity parameters, such as 1-dB gain compression point or third-order intercept point IP3, by which the EVM and ACPR are simulated. A standard NADC modulated signal from a HP ESG-D signal generator is applied to the MMIC PA and the output signal analyzed by a HP 89410A vector signal analyzer. The measured results agree well with the simulation curves. This shows that the computer program by Matlab is useful to RF/microwave system engineers in the design of power amplifiers for digital wireless communications.
An Anomaly-Based Method for DDoS Attacks Detection using RBF Neural Networks (2011)

Distributed denial of service (DDoS) attacks are serious threats for availability of the internet services. These types of attacks command multiple agents to send a great number of packets to a victim and thus can easily exhaust the resources of the victim. In this paper we propose an anomaly-based DDoS detection method based on the various features of attack packets, obtained from study the incoming network traffic and using of Radial Basis Function (RBF) neural networks to analyze these features. We evaluate the proposed method using our simulated network and UCLA Dataset. The results show that the proposed system can make real-time detection accuracy better than 96% for DDoS attacks.
Photo- and Thermo-Chromic Liquid Crystal Polymers with Spiropyran Groups (1988)

Abstract Side chain liquid crystal polymers containing spiropyran and mesogenic units give photo- and thermo-chromic mesophases. Structural changes of the mesomorphic systems can be induced by the reversible spiropyran-merocyanine dye conversion.
Smart-phone application for autonomous indoor positioning (2015)

In this paper, we propose an architecture for autonomous indoor positioning system. In particular, we consider a system where motion sensors along with magnetometer and barometer are used to provide accurate positioning information even in environments without GNSS (Global Navigation Satellite System) coverage. We look more into implementation details of one particular block (step detection) on a smart-phone platform. Finally, we evaluate step detection performance in experimental setup.
Comparison of C-reactive protein and high-sensitivity C-reactive protein levels in patients on hemodialysis. (2012)

Chronic inflammation is highly prevalent in patients on hemodialysis (HD), as evidenced by increased levels of C-reactive protein (CRP). We compared CRP to high-sensitivity C-reactive protein (hs-CRP) to determine whether it has any clinical implications and prognostic significance in terms of mortality. CRP was measured using a standard immunoturbidometric assay on the COBAS® INTEGRA system and hs-CRP was measured using the Dade Behring on the Konelab Nephelometer in 50 patients on HD. CRP (≥6 mg/L) and hs-CRP (≥3 mg/L) levels were elevated in 30% and 54% of the patients, respectively. A significant correlation was noted between hs-CRP and CRP levels (r = 0.98, P <0.001). Deming regression analysis showed that the slope was near one (r = 0.90; 0.83-0.94) and that the intercept was small. Multivariate regression confirmed that age above 40 years (RR = 3.69, P = 0.027) and duration on HD greater than five years (RR = 3.71, P = 0.028) remained significant independent predictors of serum hs-CRP. Thirteen patients died during follow-up (26%). Multivariate Cox regression demonstrated that hs-CRP (RR = 1.062, P = 0.03) and CRP levels (RR = 1.057, P = 0.009) and age (RR = 1.078, P = 0.001) were the most powerful predictors of mortality. The CRP standard assay presents a reasonable alternative to the hs-CRP assay in patients on HD. The advantages of the CRP standard assay are its online and real-time availability as well as lower costs, particularly in developing countries.
Supporting Blockchain-Based Cryptocurrency Mobile Payment With Smart Devices (2020)

The smart device owning rate such as smart phone and smart watch is higher than ever before and mobile payment has become one of the major payment methods in many different areas. At the same time, blockchain-based cryptocurrency is becoming a nonnegligible type of currency and the total value of all types of cryptocurrency has reached USD 200 billion. Therefore, it is a natural demand to support cryptocurrency payment on mobile devices. Considering the poor infrastructure and low penetration of financial service in developing countries, this combination is especially attractive. The high storage cost and payment processing latency are the two main obstacles for mobile payment using cryptocurrency. We propose two different schemes for cryptocurrency mobile payment, one involves a centralized bank and the other one does not require any centralized party. We also provide a solution for the bank to meet KYC (know your customer)/AML (antimoney laundering) compliance requirements when it is involved in cryptocurrency mobile payment processing.
Analysis and design of impedance-transforming planar Marchand baluns (2001)

A technique for designing impedance-transforming baluns is presented in this paper. It is based on the Marchand balun with two identical coupled lines. By varying the coupling factor of the coupled sections, a wide range of impedance transforming ratios can be achieved. In addition, a resistive network added between the balun outputs is proposed to achieve balun output matching and isolation. Microstrip baluns, matched at all ports, for transforming from a 50-/spl Omega/ source impedance to 40-/spl Omega/ as well as 160-/spl Omega/ load terminations are realized to demonstrate the technique.
Der Einfluß der Besteuerung auf die Investitionspolitik der Unternehmungen (1968)

ZusammenfassungInvestitionsentscheidungen legen das Unternehmensgeschehen auf lange Sicht fest. Einer systematischen Investitionsplanung kommt deshalb entscheidende Bedeutung zu. Hier soll untersucht werden: Wie nehmen Steuern Einfluß auf die unternehmerischen Investitionsentscheidungen? Wie können sie in der Investitionsplanung berücksichtigt werden?
.alpha.-Methylene lactones. VIII. Blocking and deblocking of .alpha.-methylene-.gamma.-butyrolactones (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.alpha.-Methylene lactones. VIII. Blocking and deblocking of .alpha.-methylene-.gamma.-butyrolactonesPaul A. Grieco and Masaaki MiyashitaCite this: J. Org. Chem. 1975, 40, 8, 1181–1183Publication Date (Print):April 1, 1975Publication History Published online1 May 2002Published inissue 1 April 1975https://pubs.acs.org/doi/10.1021/jo00896a045https://doi.org/10.1021/jo00896a045research-articleACS PublicationsRequest reuse permissionsArticle Views138Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Scaling Up the Ligas e Chain Reaction-Based Approach to Gen e Synthesi s (2001)

as a template for PCR. Sequencing of the plasmid DNA can now be performed using two PCR primers flanking the MCS of the vector (we used M13 universal forward primer and M13 universal reverse primer; Figure 1). If the unique primer is set 100–150 bp from the end of the known sequence, sufficient overlapping sequence is generated to align the sequences unambiguously. This method was used in our laboratory for several cycles of sequencing. In the overlapping sequence, all bases were identical, suggesting that this method is not only fast and inexpensive but also accurate.
A Low-Cost Palmtop High-Speed Capillary Electrophoresis Bioanalyzer with Laser Induced Fluorescence Detection (2018)

In this work, we developed a miniaturized palmtop high-speed capillary electrophoresis (CE) system integrating whole modules, including picoliter-scale sample injection, short capillary-based fast CE, high-voltage power supply, orthogonal laser induced fluorescence (LIF) detection, battery, system control, on-line data acquisition, processing, storage, and display modules. A strategy of minimalist miniaturization combining minimal system design and low-cost system construction was adopted to achieve the instrument miniaturization with extremely low cost, which is differing from the current microfabrication strategy used in most reported miniaturized CE systems. With such a strategy, the total size of the bioanalyzer was minimized to 90 × 75 × 77 mm (length × width × height) and the instrument cost was reduced to ca. $500, which demonstrated the smallest and lowest-cost CE instrument with LIF detection in so far reported systems. The present bioanalyzer also exhibited comparable analytical performances to previously-reported high-speed CE systems. A limit of detection of 1.02 nM sodium fluorescein was obtained. Fast separations were achieved for multiple types of samples as amino acids, amino acid enantiomers, DNA fragments, and proteins with high efficiency. We applied this instrument in colorectal cancer diagnosis for detecting KRAS mutation status by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
NR2B‐NMDA receptor mediated modulation of the tyrosine phosphatase STEP regulates glutamate induced neuronal cell death (2010)

The present study examines the role of a neuron-specific tyrosine phosphatase (STEP, striatal-enriched tyrosine phosphatase) in excitotoxic cell death. Our findings demonstrate that p38 MAPK, a stress-activated kinase that is known to play a role in the etiology of excitotoxic cell death is a substrate of STEP. Glutamate-mediated NMDA receptor stimulation leads to rapid but transient activation of p38 MAPK, which is primarily dependent on NR2A-NMDA receptor activation. Conversely, activation of NR2B-NMDA receptors leads to dephosphorylation and subsequent activation of STEP, which in turn leads to inactivation of p38 MAPK. Thus, during transient NMDA receptor stimulation, increases in STEP activity appears to limit the duration of activation of p38 MAPK and improves neuronal survival. However, if NR2B-NMDA receptor stimulation is sustained, protective effects of STEP activation are lost, as these stimuli cause significant degradation of active STEP, leading to secondary activation of p38 MAPK. Consistent with this observation, a cell transducible TAT-STEP peptide that constitutively binds to p38 MAPK attenuated neuronal cell death caused by sustained NMDA receptor stimulation. The findings imply that the activation and levels of STEP are dependent on the duration and magnitude of NR2B-NMDA receptor stimulation and STEP serves as a modulator of NMDA receptor dependent neuronal injury, through its regulation of p38 MAPK.
Enhancement of Stress-Induced Synthesis of Stress Proteins by Mastoparan in C6 Rat Glioma Cells1 (1995)

The levels of two small stress proteins, hsp27 and alpha B crystallin, were low in C6 glioma cells confluency. However, the levels of the two proteins increased after exposure of cells to heat (42 degrees C for 30 min) or arsenite (50-100 microM for 1 h) stress. When cells were exposed to arsenite or heat in the presence of mastoparan, a peptide toxin from wasp venom, the induction of hsp27 and alpha B crystallin was markedly stimulated, as detected by means of specific immunoassays, Western blot analysis, and Northern blot analysis. The response of hsp70 to each stress was also enhanced in the presence of mastoparan. Treatment of cells with 40 microM mastoparan alone barely induced the accumulation of hsp27 and alpha B crystallin. The stimulatory effect of mastoparan was little affected in cells that had been treated with pertussis toxin, but it was strongly suppressed in the presence of quinacrine, an inhibitor of phospholipase A2. These results suggest that mastoparan, which is an activator of phospholipase A2, enhances the responses to stress of hsp27, alpha B crystallin and hsp70 by increasing the metabolic activity of the arachidonic acid cascade.
Perceivers' Explanations of Their Attributions of Attitudel (1976)

Subjects attributed attitudes to a target person who had produced an essay on a social issue. The target was described as having a choice in defending a position (pro or anti) or being assigned a position. A variant of the latter condition included a prompting cue which consisted of asking subjects to rate the target's degree of choice. Inferences of attitude were most correspondent with essay position in the choice condition and least correspondent in the prompted condition. The prompting cue thus sensitized perceivers to the target's constraint. Only 28% of subjects who judged a target under constraint explicitly mentioned the constraint factor when explaining their attribu tions, a result supportive of Jones and Nisbett's (1971) thesis.
Tomographic phase microscopy with 180° rotation of live cells in suspension by holographic optical tweezers (2015)

We present a new tomographic phase microscopy (TPM) approach that allows capturing the three-dimensional refractive index structure of single cells in suspension without labeling, using 180° rotation of the cells. This is obtained by integrating an external off-axis interferometer for wide-field wave front acquisition with holographic optical tweezers (HOTs) for trapping and micro-rotation of the suspended cells. In contrast to existing TPM approaches for cell imaging, our approach does not require anchoring the sample to a rotating stage, nor is it limited in angular range as is the illumination rotation approach. Thus, it allows noninvasive TPM of suspended live cells in a wide angular range. The proposed technique is experimentally demonstrated by capturing the three-dimensional refractive index map of yeast cells, while collecting interferometric projections at an angular range of 180° with 5° steps. The interferometric projections are processed by both the filtered back-projection method and the diffraction theory method. The experimental system is integrated with a spinning disk confocal fluorescent microscope for validation of the label-free TPM results.
Generalised Hash Teams for Join and Group-by (1999)

We propose a new class of algorithms that can be used to speed up the execution of multi-way join queries or of queries that involve one or more joins and a group-by. These new evaluation techniques allow to perform several hash-based operations (join and grouping) in one pass without repartitioning intermediate results. These techniques work particularly well for joining hierarchical structures, e.g., for evaluating functional join chains along key/foreign-key relationships. The idea is to generalize the concept of hash teams as proposed by Graefe et.al [GBC98] by indirectly partitioning the input data. Indirect partitioning means to partition the input data on an attribute that is not directly needed for the next hash-based operation, and it involves the construction of bitmaps to approximate the partitioning for the attribute that is needed in the next hash-based operation. Our performance experiments show that such generalized hash teams perform significantly better than conventional strategies for many common classes of decision support queries.
Using Downhole Annular Pressure Measurements to Anticipate Drilling Problems (1998)

Abstract Downhole annular pressure is becoming a standard measurement in all drilling environments. When monitored in the context of other drilling parameters, and with a fundamental understanding of hydraulics principles it is possible to identify undesirable drilling conditions, suggest remedial procedures, and help prevent serious problems from developing. For wells with only a small difference between fracture gradient and pore pressure, drilling without realtime downhole annular pressure information may not be possible. Indeed, this is particularly true for extended reach wells, for high temperature / high pressure (HTHP) wells, and in deep water environments where large flowing friction pressure losses or very narrow pressure margins can exist. Previous publications have discussed how with realtime downhole annular pressure measurements a driller can more effectively maintain the equivalent circulating density (ECD) and equivalent static density (ESD- when not circulating) within a desired range in order to prevent lost circulation and maintain borehole integrity (including managing swab, surge and gel breakdown effects). Annular pressure data are used to evaluate the effects of flow and pipe rotation on the ECD, and to evaluate formation integrity tests. With accurate downhole data the driller can apply conventional drilling practices more effectively to reduce both rig time and potentially also the number of required casing strings. In order to interpret annular pressure measurements it is important to first understand the physical hydrodynamic principles. It is also important to analyze pressure data in the context of all downhole and surface drilling parameters. Recent experiences with downhole pressure data have demonstrated how ECD trends can be used to anticipate drilling problems before they develop into serious events. Even with the ECD within its desired range, drilling problems not apparent from conventional procedures can be anticipated. We present three case histories. The first is from an extended reach drilling project where the annular pressure data gave advanced warning of high cuttings loading, and helped avoid a potential lost circulation or stuck pipe event. This example also illustrates the significant flowing pressure losses that can occur along an extended reach wellbore. A second case history demonstrates the importance of using annular pressure measurements in deep water environments both to establish and maintain safe pressure margins. Downhole pressure data can also be used to evaluate kill procedures. The final example was from an extended reach well where the drilling fluid had sagged during a bit trip, and shows how by evaluating downhole annular pressure measurements, safer and more efficient tripping practices can be developed. P. 535
Kinetic Fast Ignition Fusion (2014)

This is the first fusion method provably viable at utility scale. Energy input is by charged pellets fired at ultraspeed from modified particle accelerators, a technique routinely used to test spacecraft meteor shields, and first proposed as a fusion driver 50 years ago. A key enabling technology, now available, is the ability to track and steer individual pellets in flight, permitting very precise delivery independent of distance from accelerator to target. A train of pellets fired at successively increasing speed catch up together over a long flightpath to arrive as a unit: an accelerator of modest power can deliver an intense input. For an efficient fast ignition strategy, medium-speed pellets impact and heat a hohlraum, causing 3-D compression of a hemispherical fuel capsule within. Smaller faster pellets fired from a parallel accelerator converge into a dense bullet, which strikes the compressed fuel to ignite it. Technical risk is negligible because:- Fuel compression required is less than already achieved in NIF.- Subsequent ignition is so rapid that there is no chance for instabilities to disrupt it by fuel redistribution or mixing.- All materials and components required have been successfully manufactured. The system can burn deuterium-tritium fuel closely and completely surrounded by lithium, for a closed fuel cycle with no radioactivity issues. Capital cost will be modest: it may even be possible to modify existing coal-fired plant for fusion. Key features are claimed in patents currently in the national phase worldwide. v1.0 13 October 20142 1.
The Role of Integrins in Tumorigenesis and Metastasis (1998)

(1998). The Role of Integrins in Tumorigenesis and Metastasis. Cancer Investigation: Vol. 16, No. 5, pp. 329-344.
Performance characteristics of mirror servers on the Internet (1999)

As a growing number of Web sites introduce mirrors to increase throughput, the challenge for clients is determining which mirror will offer the best performance when a document is to be retrieved. We present findings from measuring 9 clients scattered throughout the United States retrieving over 490,000 documents from 47 production Web servers which mirror three different Web sites. We have several interesting findings that may aid in the design of protocols for choosing among mirror servers. Though server performance varies widely, we have observed that a server's performance relative to other servers is more stable and is independent of time scale. In addition, a change in an individual server's transfer time is not a strong indicator that its performance relative to other servers has changed. Finally, we have found that clients wishing to achieve near-optimal performance may only need to consider a small number of servers rather than all mirrors of a particular site.