gebhart/patrepeval huggingface dataset:
Drug-Phospholipid Interactions: Role in Aminoglycoside Nephrotoxicity (1992)

Aminoglycoside antibiotics are known to be transported and accumulated within lysosomes of renal proximal tubular cells and to cause proximal tubular cell injury and necrosis. The pathogenesis of aminoglycoside nephrotoxicity is postulated to be related to the capacity of these organic polycations to interact electrostatically with membrane anionic phospholipids and to disrupt membrane structure and function. Aminoglycoside antibiotics have been shown to bind to anionic phospholipids of model membranes and to alter membrane permeability and promote membrane aggregation. In vivo these drugs induce phospholipiduria and a renal cortical phospholipidosis. The latter reflects the accumulation of phospholipid-containing myeloid bodies within the lysosomal compartment consequent to aminoglycoside-induced inhibition of lysosomal phospholipases. The mechanism of drug-induced inhibition of phospholipases has been shown to be secondary to the binding of these cationic drugs to anionic phospholipids. As the lysosomes became progressively distended with myeloid bodies, they become unstable and eventually rupture, which results in the release of acid hydrolases as well as high concentrations of aminoglycosides into the cytoplasm where they interact with and disrupt the function of other membranes and organelles including mitochondria and microsomes. It is postulated that the redistribution of drug from the lysosomal compartment to organellar membranes is the critical event which triggers the irreversible injury cascade. Polyaspartic acid is a polyanionic peptide which when administered in vitro or in vivo forms electrostatic complexes with aminoglycoside antibiotics and prevents these drugs from interacting with anionic phospholipids, from perturbing phospholipid metabolism and from causing cell injury and necrosis.
Microwave Field-Effect Transistors - 1976 (1976)

A review of recent and current work on microwave FET's and amplifiers is presented, and an extensive bibliography of recent articles is appended (250 references). First, the various FET structures (MRSFET's, JFET's, and IGFET's) and their performances are reviewed. Second, the principle of operation is outlined for Si- and GaAs-MESFET's; the basic device physics, equivalent circuit, high-frequency limitations, and noise behavior are treated. Third, the design principles and performance of microwave MESFET amplifiers are summarized.
童心大使 彭磊 在铁皮玩具中寻访童年 (2008)

彭磊绝对是个酷玩儿一族,他的发条怪兽玩具店最早开在后海,小有名气,这个青年身上永远散发着一种时尚前卫的气质,除了punk乐队新裤子的主唱,他还是个骨灰级的玩具先锋,用黏土做动画MV,写关于玩具制作的书,
Performance of immobilized enzyme on saccharification and fermentation of agricultural wastes and wood residues (1991)

Summary The saccharification of agricultural wastes and wood residues are studied using a commercial enzyme preparation, “Aspergillus Niger”;, immobilized onto a support matrix ‐ glass beads. The performance of the immobilized enzyme on the rate of saccharification of the cellulose is studied. A comparison is made of the rate of saccharif ication using free enzyme with the immobilized enzyme system. The organism, media and environments are identical in both systems, so that the performance can be compared directly. The study also deals with the fermentable sugars and their subsequent conversion to ethyl alcohol. The yeast “Saccharomyces Cerevisia”; is used in the ethyl alcohol fermentation. Simultaneous saccharification‐fermentation studies are also conducted. The present work aims at developing a reasonably stable model reaction system to saccharify untreated cellulose and cellulose pretreated physically or chemically. This work provides information on the nature of treatments given to the substrate, the enzyme stability and optimum operating conditions.
The development of hydrogen sensor technology for aerospace applications (1993)

The motivation and present status of each of the major components of the NASA Lewis Research Center hydrogen sensor program. The testing facility used to test the sensors and the proposed expansion of this facility are discussed. The Schottky diode prototype sensors, the use of SiC as a semiconductor for a hydrogen sensor, and the present characterization of PdCr are addressed. Future directions for the program are examined. It is concluded that results thus far are encouraging and that further development work is necessary.
Virus-like particles for the prevention of human papillomavirus-associated malignancies (2013)

As compared with peptide- or protein-based vaccines, naked DNA vectors and even traditional attenuated or inactivated virus vaccines, virus-like particles (VLPs) are an attractive vaccine platform, as they offer a combination of safety, ease of production and both high-density B-cell epitope display and intracellular presentation of T-cell epitopes that induce potent humoral and cellular immune responses, respectively. Indeed, HPV vaccines based on VLP production by recombinant expression of major capsid antigen L1 in yeast (Gardasil(®), Merck & Co., NJ, USA) or insect cells (Cervarix(®), GlaxoSmithKline, London, UK) have been licensed for the prevention of cervical and anogenital infection and disease associated with the genotypes targeted by each vaccine. However, these HPV vaccines have not been demonstrated as effective to treat existing infections, and efforts to develop a therapeutic HPV vaccine continue. Furthermore, current HPV L1-VLP vaccines provide type-restricted protection, requiring highly multivalent formulations to broaden coverage to the dozen or more oncogenic HPV genotypes. This raises the complexity and cost of vaccine production. The lack of access to screening and high disease burden in developing countries has spurred efforts to develop second-generation HPV vaccines that are more affordable, induce wider protective coverage and offer therapeutic coverage against HPV-associated malignancies. Given the previous success with L1-VLP-based vaccines against HPV, VLPs have been also adopted as platforms for many second-generation HPV and non-HPV vaccine candidates with both prophylactic and therapeutic intent. In this article, the authors examine the progress and challenges of these efforts, with a focus on how they inform VLP vaccine design.
Application of Natural Language Processing in Object Oriented Software Development (2014)

Software Development Life Cycle (SDLC) starts with eliciting requirement of user as a document called Software Requirement Specification (SRS). SRS document is mostly written in the form of any natural language (NL) that is convenient for the client. In order to develop a right software based on user's requirements, the objects, methods and attributes needs to be identified from SRS document. In this paper, an attempt is made to develop a methodology, using the concept of Natural Language Processing (NLP) for Object Oriented (OO) Programming System analysis concept, by finding out the class name and its details directly form SRS.
Lysophosphatidyl Choline, a Chemotactic Factor for Monocytes/T-Lymphocytes Is Elevated in Endometriosis (1998)

Inflammatory processes have been hypothesized to mediate some of the clinical sequelae associated with endometriosis. The peritoneal fluid (PF) of women with endometriosis is known to contain more inflammatory cells and their associated cytokines, chemokines, and growth factors. This work provides strong evidence for oxidative stress in the PF of women with endometriosis. 1) The low density lipoprotein (LDL) isolated from the PF of subjects with endometriosis shows a small but detectable increase in electrophoretic mobility compatible with mildly oxidized LDL compared with LDL isolated from the plasma of the same subjects and PF of controls. 2) Isolated PF-LDL of endometriosis subjects is more readily oxidized in vitro than PF-LDL of controls, or LDL isolated from plasma. 3) Vitamin E content is significantly lower in endometriosis PF compared with controls, and compared with plasma of women with endometriosis and controls. No difference is seen between plasma and PF of control subjects. 4) The ratio of phosphatidylcholine/lyso phosphatidylcholine (Ptd/lyso PtdCho) in the PF of endometriosis subjects is significantly lower compared with PF of controls. Taken together, these data provide strong evidence for a pro-oxidant environment in the peritoneal cavity of women with endometriosis. Lyso PtdCho, a product derived from phospholipase A2 action on peroxidized phosphatidylcholine and a potent chemotactic factor for monocytes and T-lymphocytes, is elevated in endometriosis. We hypothesize that the increased presence of lipid peroxidation products in the PF of endometriosis subjects may, at least partly, account for the recruitment of leukocytes, the increase in macrophage activation, the secretion of monocyte--macrophage-derived cytokines, and the endometrial growth-promoting activity associated with endometriosis.
A hierarchical approach to extracting polygons based on perceptual grouping (2002)

Presented in this paper is a method of extracting linear components and polygons in images based on perceptual grouping. In order to reduce the search space which occurs in grouping linear primitives, the method introduces a token-sorting algorithm, where the primitives are sorted according to their slopes and the x-y coordinates of their ending points after the tokens are rotated by the angle of the slope. Experimental results demonstrate that the proposed method is more noise-insensitive and more efficient than conventional methods based on the Hough transform in the aspects of storage and computation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Association between Time Spent Outdoors and Myopia Using a Novel Biomarker of Outdoor Light Exposure (2012)

Study authors identified a protective association between increasing UVAF and myopia. The protective association of higher UVAF against myopia was stronger than that of increased levels of time spent outdoors as measured by this study's questionnaire. Future studies should investigate the association between UVAF and incident myopia, and its relationship to myopic progression.
A polymerase chain reaction assay for ascosporic inoculum of <i>Sclerotinia</i> species (2015)

A polymerase chain reaction (PCR) assay was developed that amplified a 170‐bp fragment of the intergenic spacer region of Sclerotinia sclerotiorum , the cause of white mould. Sensitivity was 10 S. sclerotiorum ascospores per DNA extraction (0.2 ascospores per PCR reaction). The presence of soil did not affect sensitivity at 50, 100 and 500 ascospores/DNA extraction, but reduced sensitivity at 25 and 10 ascospores/DNA extraction by 10% and 30%, respectively. The assay did not amplify DNA of Botrytis cinerea but detected S. minor and S. trifoliorum . Utility of the test for detection of S. sclerotiorum ascospores in bean fields was demonstrated using rotating impaction samplers over two seasons. The use of the test in combination with an impaction sampler may provide benefits in time, sensitivity and specificity compared with visual identification and enumeration of spores from traps only. This system may provide an opportunity to schedule fungicides during periods of inoculum presence for disease management.
Plasmodium falciparum rosetting is associated with malaria severity in Kenya (1995)

Rosette formation in 154 fresh Plasmodium falciparum isolates from Kenyan children with mild (n = 54), moderate (n = 64), or severe (n = 36) malaria was studied to determine whether the ability to form rosettes in vitro is correlated with malaria severity. There was a wide distribution of rosette frequencies within each clinical category; however, a clear trend towards higher rosette frequency with increasing severity of disease was seen, with the median rosette frequency of the mild-malaria group (1%; range, 0 to 82%) being significantly lower than those of the moderate-malaria group (5%; range, 0 to 45%; Mann-Whitney U test, P < 0.02) and the severe-malaria group (7%; range, 0 to 97%; Mann-Whitney U test, P < 0.003). Within the severe-malaria category there was no difference in rosetting among isolates from cerebral malaria patients or those with other forms of severe malaria. We also examined the ABO blood groups of the patients from whom isolates were obtained and found that isolates from group O patients (median rosette frequency, 2%; range 0 to 45%) rosetted less well than those from group A (median, 7%; range 0 to 82%; Mann-Whitney U test, P < 0.01) or group AB (median, 11%; range 0 to 94%; Mann-Whitney U test, P < 0.03). We therefore confirm that rosetting is associated with severe malaria and provide further evidence that rosetting is influenced by ABO blood group type. Whether rosetting itself plays a direct role in the pathogenesis of severe malaria or is a marker for some other causal factor remains unknown.
Soil Erosion and Sediment Control Effects in the Three Gorges Reservoir Region, China (2011)

Abstract: The Three Gorges Reservoir, the world's largest hydropower reservoir, receives a significant sediment yield from soil erosion. Sloping farmland is the main source, exacerbated by changes in land use from relocating the inhabitants, and from engineering projects related to dam construction. Related geo—hazards, including landsliding of valley—side slopes, will further increase the sediment yield to the completed reservoir. Integrated watershed management, begun extensively in 1989, has effectively controlled soil erosion and sediment delivery to date. What is described here as the Taipinxi Mode of integrated watershed management, based on its application in the 26.14 km2 watershed of that name in Yiling District, has been successful and is recommended for the entire region. The effects of this set of erosion—mitigation measures are assessed, using experienced formulas for soil and water conservation and information from remote sensing. The amount of soil erosion, and of sediment delivery to the reservoir were reduced by 43.75–45.94 × 106 t y-1, and by 12.25–12.86 × 106 t y-1, respectively, by 2005, by which time the project had been operative for 16 years.
Automated document distribution using AI based workstations and knowledge based servers (2003)

An approach is presented to document distribution in a large corporation via a corporate communications system using artificial intelligence and expert system concepts. A document is originated as an electronic file on a user workstation (WS), called the writer. The document is processed by an inference engine in the WS and appends the list of signers and reviewers. The document is then sent to a knowledge base server (KBS), which adds additional information regarding the distribution of the document. The activity of reviewing and signing the documents originated at the user WS. The document is retrieved from the KBS, reviewed by the user, signed, and returned to the KBS for intermediate storage. When the KBS has determined that the document has all the required signatures, the document is sent to the final destination. The system has been demonstrated using a C language implementation on personal computer workstations and a Unix-based KBS.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Safe Driving and Accidental Monitoring Using GPS System and Three Axis Accelerometer (2013)

Abstract — Mobile phones today are equipped with inbuilt sensors that give safety enhancement to the drivers on road. The three axis accelerometer and a GPS tracking system of smart phone can give assistance to the driver while travelling. In this paper the emphasis is on safety with advanced driver assistance system (ADAS’s). The three axis accelerometer of an Android based smart phone is used to record and analyse various and external road conditions that could be hazardous to the health of the driver and the automobile. With real time analysis and alerts of these factors, we can increase a driver’s overall awareness to maximize safety. Google Earth is used to create road condition maps using GPS coordinates. In addition to this the accelerometer can be used to design and implement a fall monitor with GPS system and GSM module. A wireless black box using GPS tracking and GSM module can be developed for accidental monitoring.
A Photo-Crosslinkable Chitosan Hydrogel for Peripheral Nerve Anastomosis (2009)

The predominant therapy for peripheral nerve transection is anastomosis by suture. However, sutures have been known to lead to tissue inflammation, granulomas, and poor functional outcomes. While adhesives offer a promising alternative, fibrin-the predominant bio-glue-can transmit disease. Here we examine a photocrosslinkable chitosan hydrogel for use in surgical therapies for peripheral nerve injury. Prepared by conjugating 4-azidobenzoic acid to amino groups of chitosan using carbodiimide chemistry, this formulation demonstrates a high potential of in-situ photocrosslinking. A 40 mg/mL solution gels under 40 s of UV illumination. This gel is demonstrated to be cytocompatible with neural cell populations and is not acutely toxic to nerve conduction ex vivo. Mechanical testing of nerves anastomosed by this hydrogel had tensile strengths comparable to conventional fibrin glues. These results show chitosan hydrogel to be biocompatible and mechanically suitable for use in nerve repair.
Speech Loss Compensation by Generative Adversarial Networks (2019)

Speech loss, including frequency loss and packet loss, can lead to significant speech distortion in many Internet-based speech communication services. In this study, a generative adversarial networks (GANs) structure, which takes deep convolutional neural networks (CNN) as the generator and discriminator components, is adopted as a general framework for speech loss compensation. Network settings are modified for real-time communications. A set of experiments are conducted to evaluate the performance of the GANs-based framework for both bandwidth expansion (BWE) and packet loss concealment (PLC) at several simulated loss conditions. Experimental results demonstrate that the proposed system achieves better performance, with respective to 4 objective metrics, in both BWE and PLC compared to the baseline systems.
Some Recent Theories of the Origin of the Apocalypse (1891)

Research Article| June 01 1891 Some Recent Theories of the Origin of the Apocalypse Edward Caldwell Moore Edward Caldwell Moore Search for other works by this author on: This Site Google Journal of Biblical Literature (1891) 10 (1): 20–43. https://doi.org/10.2307/4617095 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Edward Caldwell Moore; Some Recent Theories of the Origin of the Apocalypse. Journal of Biblical Literature 1 June 1891; 10 (1): 20–43. doi: https://doi.org/10.2307/4617095 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All Scholarly Publishing CollectiveSBL PressJournal of Biblical Literature Search Advanced Search The text of this article is only available as a PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
A close correlation between electron spin resonance (ESR) dosimetry from tooth enamel and cytogenetic dosimetry from lymphocytes of Hiroshima atomic-bomb survivors (1998)

Both tooth enamel ESR and lymphocyte cytogenetics are useful measures for individual biodosimetry of acute radiation exposure, even half a century after the exposure occurred.
An Integrated Approach for Identification and Target Validation of Antifungal Compounds Active against Erg11p (2012)

Systemic life-threatening fungal infections represent a significant unmet medical need. Cell-based, phenotypic screening can be an effective means of discovering potential novel antifungal compounds, but it does not address target identification, normally required for compound optimization by medicinal chemistry. Here, we demonstrate a combination of screening, genetic, and biochemical approaches to identify and characterize novel antifungal compounds. We isolated a set of novel non-azole antifungal compounds for which no target or mechanism of action is known, using a screen for inhibition of Saccharomyces cerevisiae proliferation. Haploinsufficiency profiling of these compounds in S. cerevisiae suggests that they target Erg11p, a cytochrome P450 family member, which is the target of azoles. Consistent with this, metabolic profiling in S. cerevisiae revealed a buildup of the metabolic intermediates prior to Erg11p activity, following compound treatment. Further, human cytochrome P450 is also inhibited in in vitro assays by these compounds. We modeled the Erg11p protein based on the human CYP51 crystal structure, and in silico docking of these compounds suggests that they interact with the heme center in a manner similar to that of azoles. Consistent with these docking observations, Candida strains carrying azole-resistant alleles of ERG11 are also resistant to the compounds in this study. Thus, we have identified non-azole Erg11p inhibitors, using a systematic approach for ligand and target characterization.
Differential ROCOF relay for Loss-of-Mains protection of Renewable Generation using phasor measurement over Internet Protocol (2009)

Renewable Generation typically falls into the category of embedded generation subject to Loss-of-Mains protection requirements. Loss-of-Mains protection is intended to avoid out of synchronism connection of an operating embedded generator to the utility supply after restoration of a fault. Present day technologies, such as ROCOF and Vector Shift are widely known to suffer from nuisance tripping and mal-operation caused by system-wide disturbances. This paper examines the use of modern day technologies to provide enhanced Loss-of-Mains protection using synchrophasor measurements delivered over Internet Protocol telecommunications. It will be shown that such a technique reduces the impact of nuisance tripping and allows embedded generation to ride through faults.