gebhart/patrepeval huggingface dataset:
Generation of Anti-apoptotic Presenilin-2 Polypeptides by Alternative Transcription, Proteolysis, and Caspase-3 Cleavage (1997)

PS2, the chromosome 1 familial Alzheimer's disease gene, has been shown to be involved in programmed cell death by three complementary experimental approaches. Reduction of PS2 protein levels by antisense RNA protects from apoptosis, whereas overexpression of an Alzheimer's PS2 mutant increases cell death induced by several stimuli. In addition, ALG-3, a truncated PS2 cDNA, encodes an artificial COOH-terminal PS2 segment that dominantly inhibits apoptosis. Here we describe a physiological COOH-terminal PS2 polypeptide (PS2s, Met298-Ile448) generated by both an alternative PS2 transcript and proteolytic cleavage. We find that PS2s protects transfected cells from Fas- and tumor necrosis factor alpha (TNFalpha)-induced apoptosis. Furthermore, a similar anti-apoptotic COOH-terminal PS2 polypeptide (PS2Ccas) is generated by caspase-3 cleavage at Asp329. These results suggest that caspase-3 not only activates pro-apoptotic substrates but also generates a negative feedback signal in which PS2Ccas antagonizes the progression of cell death. Thus, whereas PS2 is required for apoptosis, PS2s and PS2Ccas oppose this process, and the balance between PS2 and these COOH-terminal fragments may dictate the cell fate.
A Sampling-Based Approach to Information Recovery (2008)

There has been a recent resurgence of interest in research on noisy and incomplete data. Many applications require information to be recovered from such data. Ideally, an approach for information recovery should have the following features. First, it should be able to incorporate prior knowledge about the data, even if such knowledge is in the form of complex distributions and constraints for which no close-form solutions exist. Second, it should be able to capture complex correlations and quantify the degree of uncertainty in the recovered data, and further support queries over such data. The database community has developed a number of approaches for information recovery, but none is general enough to offer all above features. To overcome the limitations, we take a significantly more general approach to information recovery based on sampling. We apply sequential importance sampling, a technique from statistics that works for complex distributions and dramatically outperforms naive sampling when data is constrained. We illustrate the generality and efficiency of this approach in two application scenarios: cleansing RFID data, and recovering information from published data that has been summarized and randomized for privacy.
The Analysis and Comparison about Cervical Erosion Therapy Methords (2008)

Objective Introduce the treatment method that cervical erosion is different.Methods Retrospectively to analysis in 644 cervical erosion who were cured by drug therapy,physical treatment and operative treatment.Results The cure rate of drug therapy was 47.9%,total effective rate was 82.1%.The cure rate of physical treatment was 69.5%,total effective rate was 93.8%.The cure rate of drug therapy was 75.4%,total effective rate was 96.4%.Conclusion Through analysing more various treatment methods,summing up and withdrawing the needle to the case of difference,pharmacotherapy or physical treatment are selected to the different circumstances,select different treatment methods according to its weight degree again to the physical treatment.To slight cervical erosion patient,can adopt pharmacotherapy,and to the severe patient,had better adopt the physical therapy,and to performing the operation the treatment,can select according to the state of an illness the first-selected treatment method of general omission.
Tivantinib (ARQ197) Displays Cytotoxic Activity That Is Independent of Its Ability to Bind MET (2013)

We conclude that tivantinib displays cytotoxic activity via molecular mechanisms that are independent from its ability to bind MET. This notion has a relevant impact on the interpretation of clinical results, on the design of future clinical trials, and on the selection of patients receiving tivantinib treatment.
Terahertz sources and detectors based on nonlinear diodes (2004)

The terahertz frequency band, spanning from roughly 100 GHz to 10 THz, is the most scientifically rich, unexplored region of electromagnetic spectrum. This frequency band is useful for scientific, military and commercial applications as the microwave and far-infrared bands. The aim of this paper is to build sources and detectors that span the entire terahertz technology gap. This has primarily been achieved through the use of nonlinear diodes to extend microwave functionality to high frequencies. GaAs is the material of choice for the nonlinear diodes because of its high electron mobility. Here the voltages, currents and their effect on the electrons in the microwave frequency devices are also considered.
Hierachically Nanostructured Mesoporous Spheres of Calcium Silicate Hydrate: Surfactant‐Free Sonochemical Synthesis and Drug‐Delivery System with Ultrahigh Drug‐Loading Capacity (2009)

Ultrahigh drug-loading capacity and the linear relationship between the cumulative amount of released drug and the natural logarithm of release time were discovered for the hierachically nanostructured mesoporous spheres of calcium silicate hydrate (CSH) obtained by a surfactant-free sonochemical method (see figure). During the release of loaded ibuprofen in simulated body fluid, CSH gradually transformed to hydroxyapatite. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Monitoring of molten pool image during pipe welding in gas metal arc welding (GMAW) using machine vision (2011)

This paper proposes a study on monitoring of molten pool image during pipe welding in gas metal arc welding (GMAW) using machine vision. As circumferential butt-welded pipes are frequently used in power stations, offshore structures, and process industries, it is requires advance technique of welding monitoring process. The research was conducted for welding of mild steel with controlled welding speed and Charge-couple Device (CCD) camera as vision sensor. The systems used GMAW machine with DC current. Neural network used for simulation of weld bead width. The experimental result shows the effectiveness of the image processing algorithm and simulation process.
Compact MIMO PIFA for LTE/ WWAN operation in the mobile application (2014)

In this article, a multiple input multiple output (MIMO) antenna for LTE/WWAN mobile application is proposed. The designed MIMO antenna consists of two symmetric coupled-fed antenna elements which are disposed on the corners of the long edge of the system circuit board. Each of the two antenna elements occupies a small area of 13×35mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , which is small enough to be incorporated in a mobile MIMO terminal. The proposed antenna element has a simple structure of comprising a shorting strip of length about λ/8 at 1760 MHz with a tuning stub connected to it and a simple inverted-L feeding strip to capacitively excite the shorting strip. As a result, a wide operating band to cover GSM1800/1900/UMTS2100/LTE2300/ 2500 operation is obtained with desired 2:1 VSWR, and the measured isolation value (S21) between the two antenna elements is lower than -15dB. The MIMO antenna system is an all-printing structure with low production cost, which is especially suited for thin-profile mobile terminals.
Protein C Deficiency in a Dutch Family with Thrombotic Disease (1982)

A rabbit antibody against human protein C was used for the quantitative estimation of protein C in plasma. In healthy individuals protein C antigen ranged from 0.65-1.45 U/ml. Plasma protein C antigen was found to be independent of either age or sex. Under influence of oral anticoagulant treatment the protein C antigen concentration decreased to 0.47 U/ml (at low intensity treatment) or 0.33 U/ml (at high intensity treatment). Using normal ranges of protein C and protein C/factor II and protein C/factor X ratios criteria were developed for the assessment of protein C deficiency. In a Dutch family with a history of thrombotic disease two members were found to have an isolated protein C deficiency, while a third one is suspected of protein C deficiency. In one case it was possible to confirm the diagnosis of suspected protein C deficiency during temporary withdrawal of the anticoagulant therapy.
The relationship between life events and mental health in homosexual men (1990)

In a study to determine the extent to which stigmatization influences mental health in homosexual men, 80 homosexual men were administered the General Health Questionnaire and the Gay Affect and Life Events Scale. Data indicated that there were significant associations between life events and mental health; events related to AIDS had the highest correlations. However, general life event scales that included Finances and Work also were associated significantly with mental health, as previously reported in the general population. These data suggest that the impact of life events may be amplified by stigmatization and that degree of life change is associated closely with psychological dysfunction. It is concluded that life events that are related to both stigmatization and life change and related emotional distress are significant predictors of psychology dysfunction.
E2F3 activity is regulated during the cell cycle and is required for the induction of S phase (1998)

Previous work has demonstrated the important role of E2F transcription activity in the induction of S phase during the transition from quiescence to proliferation. In addition to the E2F-dependent activation of a number of genes encoding DNA replication activities such as DNA Pol alpha, we now show that the majority of genes encoding initiation proteins, including Cdc6 and the Mcm proteins, are activated following the stimulation of cell growth and are regulated by E2F. The transcription of a subset of these genes, which includes Cdc6, cyclin E, and cdk2, is also regulated during the cell cycle. Moreover, whereas overall E2F DNA-binding activity accumulates during the initial G1 following a growth stimulus, only E2F3-binding activity reaccumulates at subsequent G1/S transitions, coincident with the expression of the cell-cycle-regulated subset of E2F-target genes. Finally, we show that immunodepletion of E2F3 activity inhibits the induction of S phase in proliferating cells. We propose that E2F3 activity plays an important role during the cell cycle of proliferating cells, controlling the expression of genes whose products are rate limiting for initiation of DNA replication, thereby imparting a more dramatic control of entry into S phase than would otherwise be achieved by post-transcriptional control alone.
High-Pressure Electrical Conductivity and NMR Studies in Variable Equivalent Weight NAFION Membranes (1996)

Measurements of the electrical conductivity and proton and fluorine-19 NMR spin−lattice relaxation times (T1) in acid form NAFION 105, 117, and 120 conditioned at various levels of relative humidity have been carried out. Complex impedance studies were made along the plane of the polymer film at frequencies from 10 to 108 Hz at room temperature and pressures up to 0.3 GPa. The NMR measurements were made at room temperature and pressures up to 0.25 GPa. Both types of measurement were also carried out on various concentrations of sulfuric acid in water. The electrical conductivity decreases with increasing pressure for low water content acid solutions and low water content NAFION samples. This behavior (positive activation volumes) is that expected for "normal" liquids and for ions in polymers where the motion of the ions is determined by the host matrix. However, for high water contents, the reverse is true. The electrical conductivity increases with increasing pressure which gives rise to a negative activation volume. The results show that at high water contents, the electrical conductivity mechanism in NAFION is essentially identical to that for a dilute acid where the transport is controlled by the aqueous component. The activation volumes extracted from the proton NMR T1 data are in qualitative agreement with those obtained from the electrical conductivity measurements at intermediate and low water contents, suggesting that motion of the sulfonic acid-terminated pendant chains contributes to the conduction mechanism at low water contents.
Mechanism-based inactivation of peptidylglycine .alpha.-hydroxylating monooxygenase (PHM) by a substrate analog, D-phenylalanyl-L-phenylalanyl-D-vinylglycine: inhibition of formation of peptide C-terminal amides (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism-based inactivation of peptidylglycine .alpha.-hydroxylating monooxygenase (PHM) by a substrate analog, D-phenylalanyl-L-phenylalanyl-D-vinylglycine: inhibition of formation of peptide C-terminal amidesT. Mark Zabriskie, Hengmiao Cheng, and John C. VederasCite this: J. Am. Chem. Soc. 1992, 114, 6, 2270–2272Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://doi.org/10.1021/ja00032a058RIGHTS & PERMISSIONSArticle Views174Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (391 KB) Get e-Alerts Get e-Alerts
Phase I Trial of a Glypican-3–Derived Peptide Vaccine for Advanced Hepatocellular Carcinoma: Immunologic Evidence and Potential for Improving Overall Survival (2012)

GPC3-derived peptide vaccination was well-tolerated, and measurable immune responses and antitumor efficacy were noted. This is the first study to show that peptide-specific CTL frequency can be a predictive marker of OS in patients with HCC receiving peptide vaccination.
Molecular basis and prenatal diagnosis of beta-thalassemia (1988)

Abstract The molecular characterization of mutations producing beta-thalassemia in world populations is nearing completion. We expect that new rare alleles in thoroughly studied groups and other alleles in less studied groups, eg, inhabitants of New Guinea, Latin America, and certain Pacific Islands, will be found. Knowledge of the molecular basis of the disease and new technology that allows rapid detection of single nucleotide changes in genomic DNA have led to the reality of prenatal diagnosis by direct mutation detection even in the heterogeneous US population. Programs aimed at prevention of beta-thalassemia should be facilitated by these developments.
2‐Amino‐<scp>N</scp>‐(2,6‐dichloropyridin‐3‐yl)acetamide derivatives as a novel class of <scp>HBV</scp> capsid assembly inhibitor (2013)

Capsid structure is crucial for the maturation and maintenance of the stable hepatitis B virion. Therefore, chemicals that inhibit capsid assembly might potentially act as potent antiviral compounds. However, only a few chemicals are known to block the capsid assembly process and further viral proliferation. In this study, we present a novel family of capsid assembly inhibitors that act against hepatitis B virus (HBV). Based on X-ray crystallographic data of the HBV core protein (Cp), we built dimer and hexamer structural models to be used in library searches. Several chemicals in the 2-amino-N-(2,6-dichloropyridin-3-yl)acetamide family were predicted to have high affinity for the groove structure in Cp. Using in vitro assembly and the HepG2.2.15 cell culture test, we verified that these chemicals demonstrated inhibitory effects on capsid assembly. Furthermore, we investigated the combinatorial effects of these assembly inhibitor chemicals with lamivudine and revealed that, in combination, they have synergistic inhibitory effects on decreasing viral concentration. We propose that these inhibitors could be utilized as an effective combination treatment against HBV infection.
IEEE 1588 and a Dynamic Delay Correction Clock Synchronization Algorithm (2019)

In this paper, the authors deeply studied PTP protocol, focusing on the research of clock offset and path delay in the clock synchronization process. The authors optimized the path asymmetry of PTP transmission which is not considered in the IEEE1588 protocol, and proposed a dynamic delay correction algorithm. In the experiment, the improved algorithm is verified convergent, which proves the rationality and effectiveness of the optimization. The result is that clock synchronization accuracy improved from tens or hundreds of μs by original PTP, to tens of ns by improved algorithm. According to overseas and domestic research status, this algorithm has significantly improved time accuracy to satisfy practical requirements.
2-μm wavelength, high-energy Ho:YLF chirped-pulse amplifier for mid-infrared OPCPA (2015)

A 2-μm wavelength laser delivering up to 39-mJ energy, ∼10 ps duration pulses at 100-Hz repetition rate is reported. The system relies on chirped pulse amplification (CPA): a modelocked Er:Tm:Ho fiber-seeder is followed by a Ho:YLF-based regenerative amplifier and a cryogenically cooled Ho:YLF single pass amplifier. Stretching and compressing are performed with large aperture chirped volume Bragg gratings (CVBG). At a peak power of 3.3 GW, the stability was <1% rms over 1 h, confirming high suitability for OPCPA and extreme nonlinear optics applications.
A comparison of the distribution of tumors produced by intravenous injection of type 12 adenovirus and adeno-12 tumor cells. (1968)

Intravenous inoculation of 106 adeno-12 tumor cells in 19 newborn hamsters resulted in multiple tumors distributed in 100% of the livers, kidneys, lungs, and adrenals. All but one heart contained tumors. Gonads, spleen, and pancreas also supported tumor growth but in less than half the animals. Tumors were even fewer in the intestine, thymus, muscles, bone marrow, and brain; in the latter three areas only a single tumor was found. Tumors were not distributed according to organ weight; their distribution appeared to be influenced by anatomic and physiologic factors.

Intravenous inoculation of 108 adenovirus-12 TCD50 in 16 newborn hamsters resulted in tumors in 100% of the livers and 38% of the kidneys. Two tumors were found in the intestines and at the injection site. One tumor each developed in the lungs, pancreas, and skeletal muscle of different hamsters. Radioactive (3H) virus was relatively evenly distributed to all body organs, as determined by radioautography. Nonetheless, certain sites which had been shown to support tumor growth and which received sufficient virus remained free of virus-induced tumor. It was concluded that the liver and kidneys contained particularly susceptible “target” cells and a favorable environment for tumor growth. The heart and lungs, although presenting a presumably favorable environment, either contained insufficient “target” cells or received an insufficient virus dose.

Discussion of the distribution of tumors induced with adenovirus-12 in hamsters included a comparison with the polyoma model, a system in which the virus is known to replicate in the host as contrasted to the adenovirus model.
InAsPSb/InAs diode laser emitting in the 2.5μm range (1988)

A double heterostructure consisting of InAsPSb alloys was made by LPE-growth on InAs substrates. Lasing action was confirmed at 15–55K, where the emission wavelength was 2.5–2.7μm.
Enlightening discriminative network functional modules behind Principal Component Analysis separation in differential-omic science studies (2017)

Omic science is rapidly growing and one of the most employed techniques to explore differential patterns in omic datasets is principal component analysis (PCA). However, a method to enlighten the network of omic features that mostly contribute to the sample separation obtained by PCA is missing. An alternative is to build correlation networks between univariately-selected significant omic features, but this neglects the multivariate unsupervised feature compression responsible for the PCA sample segregation. Biologists and medical researchers often prefer effective methods that offer an immediate interpretation to complicated algorithms that in principle promise an improvement but in practice are difficult to be applied and interpreted. Here we present PC-corr: a simple algorithm that associates to any PCA segregation a discriminative network of features. Such network can be inspected in search of functional modules useful in the definition of combinatorial and multiscale biomarkers from multifaceted omic data in systems and precision biomedicine. We offer proofs of PC-corr efficacy on lipidomic, metagenomic, developmental genomic, population genetic, cancer promoteromic and cancer stem-cell mechanomic data. Finally, PC-corr is a general functional network inference approach that can be easily adopted for big data exploration in computer science and analysis of complex systems in physics.
Measurement of intracellular oxygen concentration using the spin label TEMPOL (1985)

We have developed a noninvasive method with general applicability for measuring intracellular oxygen using the spin label TEMPOL (2,2,6,6,-tetramethypiperidine-N-oxyl-4-ol) which has superhyperfine structure in its electron spin resonance spectra that is broadened in the presence of oxygen. This broadening is linear over a range of 1 to 6 ppm oxygen which covers the important physiological range of oxygen concentration. Viscosity, TEMPOL concentration, and instrument modulation intensity also can affect superhyperfine structure but the contributions from these effects can be determined. The TEMPOL distributes equally into the intra- and extracellular compartments but its intracellular signal can be studied selectively by addition of transition metal ions such as potassium ferricyanide and potassium tris(oxalato)chromiate, which broaden away the signal from extracellular TEMPOL and do not cross the cell membrane to affect the intracellular TEMPOL. Results with a cell culture line (mouse thymus-bone marrow) indicate that under our experimental conditions these cells may maintain an average intracellular oxygen concentration lower than the extracellular oxygen concentration, and that there is not a constant relationship between extracellular and intracellular oxygen concentrations.