gebhart/patrepeval huggingface dataset:
Effectiveness of Cross‐Flow Microfiltration for Removal of Microorganisms Associated with Unpasteurized Liquid Egg White from Process Plant (2009)

Thermal preservation is used by the egg industry to ensure the microbiological safety of liquid egg white (LEW); however, it does not eliminate all microorganisms and impairs some of the delicate functional properties of LEW. In this study, a pilot-scale cross-flow microfiltration (MF) process was designed to remove the natural microflora present in commercial LEW, obtained from a local egg-breaking plant, while maintaining the nutritional and functional properties of the LEW. LEW, containing approximately 10(6 +/- 1.7) colony forming units (CFU) per milliliter of total aerobic bacteria, was microfiltered using a ceramic membrane with a nominal pore size of 1.4 microm, at a cross-flow velocity of 6 m/s. To facilitate MF, LEW was screened, homogenized, and then diluted (1 : 2, w/w) with distilled water containing 0.5% sodium chloride. Homogenized LEW was found to have a threefold lower viscosity than unhomogenized LEW. Influence of MF temperature (25 and 40 degrees C) and pH (6 and 9) on permeate flux, transmission of egg white nutrients across the membrane, and microbial removal efficiency were evaluated. The pH had a significantly greater influence on permeate flux than temperature. Permeate flux increased by almost 148% when pH of LEW was adjusted from pH 9 to pH 6 at 40 degrees C. Influence of temperature on permeate flux, at a constant pH, however, was found to be inconclusive. Microbial removal efficiency was at least 5 log(10) CFU/mL. Total protein and SDS-PAGE analysis indicated that this MF process did not alter the protein composition of the permeate, compared to that of the feed LEW, and that the foaming properties of LEW were retained in the postfiltered samples.
Immune response of rhesus macaques to recombinant simian immunodeficiency virus gp130 does not protect from challenge infection (1993)

Simian immunodeficiency virus (SIV) infection of rhesus macaques is a model for human immunodeficiency virus (HIV) infection in humans. Inactivated and modified live whole-virus vaccines have provided limited protective immunity against SIV in rhesus macaques. Because of safety concerns in the use of inactivated and live whole-virus vaccines, we evaluated the protective immunity of vaccinia virus recombinants expressing the surface glycoprotein (gp130) of SIVmac and subunit preparations of gp130 expressed in mammalian cells (CHO). Three groups of animals were immunized with recombinant SIV gp130. The first group received SIV gp130 purified from genetically engineered CHO cells (cSIVgp130), the second group was vaccinated with recombinant vaccinia virus expressing SIVmac gp130 (vSIVgp130), and the third group was first primed with vSIVgp130 and then given a booster immunization with cSIVgp130. Although anti-gp130 binding antibodies were elicited in all three groups, neutralizing antibodies were transient or undetectable. None of the immunized animals resisted intravenous challenge with a low dose of cell-free virus. However, the group primed with vSIVgp130 and then boosted with cSIVgp130 had the lowest antigen load (p27) compared with the other groups. The results of these studies suggest that immunization of humans with HIV type 1 surface glycoprotein may not provide protective immunity against virus infection.
Mechanisms for pituitary tumorigenesis: the plastic pituitary (2003)

The anterior pituitary gland integrates the repertoire of hormonal signals controlling thyroid, adrenal, reproductive, and growth functions. The gland responds to complex central and peripheral signals by trophic hormone secretion and by undergoing reversible plastic changes in cell growth leading to hyperplasia, involution, or benign adenomas arising from functional pituitary cells. Discussed herein are the mechanisms underlying hereditary pituitary hypoplasia, reversible pituitary hyperplasia, excess hormone production, and tumor initiation and promotion associated with normal and abnormal pituitary differentiation in health and disease.
Numerical Simulation of Soda-Lime Silicate Glass Tempering (1996)

The paper deals with the computation of residual and transient stresses in a tempered glass plate. The modelling takes into account the viscoelastic behavior and the structural relaxation of glass. The evolution of stresses with time during the rapid cooling is computed. Simulation results are compared with experimental ones from the literature available. Levels of transient tensile stress in the surface are analysed.
Time-resolved optical tomography (1993)

We have obtained transaxial slice images of a cylindrical object containing a highly scattering, low-absorbing solution by using picosecond pulses of visible light. Embedded in the solution was an assortment of six glass tubes containing different concentrations of absorbing dye. We reconstructed images tomographically from projections generated by using light transmitted through the object with theshortest flight times.
High-density magnetic recording heads (1986)

This paper outlines the important dimensions and parameters of high-density heads and discusses why each is important and how they are related. Among factors discussed are: head-to-media spacing, record gap size, media coercivity and remanence, record demagnetization fields, record gap-edge saturation in ferrite, metal, metal-in-gap, and thin-film heads, and head wear. Gap-edge straightness is discussed. Magnetoresistive read heads are described. Vertical recording and pole-type heads are discussed. Principle sources of head noise are outlined.
Two Distinct Subpopulations of Nestin-Positive Cells in Adult Mouse Dentate Gyrus (2003)

Neurogenesis in the dentate gyrus of the adult mammalian hippocampus has been proven in a series of studies, but the differentiation process toward newborn neurons is still unclear. In addition to the immunohistochemical study, electrophysiological membrane recordings of precursor cells could provide an alternative view to address this differentiation process. In this study, we performed green fluorescent protein (GFP)-guided selective recordings of nestin-positive progenitor cells in adult dentate gyrus by means of nestin-promoter GFP transgenic mice, because nestin is a typical marker for precursor cells in the adult dentate gyrus. The patch-clamp recordings clearly demonstrated the presence of two distinct subpopulations (type I and type II) of nestin-positive cells. Type I cells had a lower input resistance value of 77.1 M(Omega) (geometric mean), and their radial processes were stained with anti-glial fibrillary acidic protein antibody. On the other hand, type II nestin-positive cells had a higher input resistance value of 2110 MOmega and expressed voltage-dependent sodium current. In most cases, type II cells were stained with anti-polysialylated neural cell adhesion molecule. Taken together with a bromodeoxyuridine pulse-chase analysis, our results may reflect a rapid and dynamic cell conversion of nestin-positive progenitor, from type I to type II, at an early stage of adult neurogenesis in the dentate gyrus.
A Fault Location Method for Active Distribution Network with Renewable Sources Based on BP Neural Network (2015)

This paper presents a neural network method to locate common fault exactly in a distribution power system (DPS) with renewable sources. The back propagation (BP) neural network method is applied to identify patterns of voltage and current measured from distribution branches. The input matrix of BP network consists of the voltage and current values, which can identify the accurate fault position. The fault location of a common short-circuit fault is analyzed thoroughly in an active distribution network (ADN) with the renewable power sources. Simulation results prove the feasibility and usefulness of the fault location method based on the BP neural network, wherein the fault location accuracy can reach 0.09%.
Kinetics of Formation and Dissociation of [Cr<sub>3</sub>O(O<sub>2</sub>CCH<sub>3</sub>)<sub>6</sub>(urea)<sub>3</sub>]<sup>+</sup>:  An Example of Statistically Controlled Kinetics and Equilibrium (1996)

Kinetics of the overall reaction [Cr(3)O(O(2)CCH(3))(6)(H(2)O)(3)](+) + 3 urea right harpoon over left harpoon [Cr(3)O(O(2)CCH(3))(6)(urea)(3)](+) + 3H(2)O have been studied spectrophotometrically. Monophasic kinetics were observed in both directions. The reverse steps, of urea dissociation, were monitored using an analytical technique which permits direct determination of the concentration of liberated urea and does not require knowledge of extinction coefficients of intermediate species. Results imply that consecutive steps occur with rate constants in close to the statistical ratios of k(1):k(2):k(3) = 3:2:1 and k(-)(1):k(-)(2):k(-)(3) = 1:2:3. Rates indicate strong labilization of urea, compared to the case of mononuclear complex [Cr(urea)(6)](3+).
An Intelligent Display Scheme of Soccer Video on Mobile Devices (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The rapid progress of the multimedia signal processing has contributed to the extensive use of multimedia devices with small liquid crystal display (LCD) panel. With the proliferation of mobile devices with a small display, the video sequences captured for normal viewing on standard TV or HDTV may give the small-display viewers uncomfortable experience in understanding what is happening in a scene. For instance, in a soccer video sequence taken by a long-shot camera technique, the tiny objects (e.g., soccer ball and players) may not be clearly visible on the small LCD panel. Thus, an intelligent display technique is needed for small-display viewers. To this end, one of the key technologies is to determine region of interest (ROI), whenever ROI display is considered more effective. </para>
Translation Controlled mRNAs: New Drug Targets in Infectious Diseases? (2008)

Recent data from a series of laboratories has pinpointed the relevant role of translation control on the regulation of gene expression. In particular, an analysis of T cell activation has led to demonstrate that during this physiological transition about 20% of the regulated mRNAs are controlled at the translation level. Furthermore, modulating the host mRNA translation is one of the mechanisms used by infectious agents to achieve a productive infection. In the present review, we summarize the current knowledge on the translation machinery, the translational control mechanisms during the immune response, as well as the mechanisms used by different pathogens to avoid, inhibit or postpone the host response; and suggest that the analysis on genome-wide screening of the host-pathogen interactions, identifying translationally regulated mRNAs, might unravel new drug targets in infectious diseases.
Infection and Atherosclerosis (1999)

Although definitive proof of a causal role of infection contributing to atherogenesis is lacking, multiple investigations have demonstrated that infectious agents evoke cellular and molecular changes supportive of such a role. Moreover, both Chlamydia pneumoniae and cytomegalovirus exacerbate lesion development in animal models of atherosclerosis and restenosis. The fact that multiple pathogens have been associated with atherosclerosis implies that many "atherogenic" pathogens exist, and recent data suggest that the risk of atherosclerosis conveyed by infection relates to the number of atherogenic pathogens with which an individual is infected. It also is evident that variability in host susceptibility to the atherogenic effects of pathogens exists; this variability appears to be related at least in part to whether the host can generate an immune response that successfully controls pathogen inflammatory activity and in part to the specific pattern of immune response--humoral or cellular. The latter may relate to host capacity to control pathogen activity and to a pathogen-induced autoimmune component of the atherogenic process. Additional animal and human studies are necessary to further test the validity of the infection/atherosclerosis link and to provide more insight into the mechanisms by which infection may contribute to atherosclerosis, information critical for devising strategies to reduce or eliminate any contribution to atherosclerosis caused by infection.
Scopadulcic acid B, a new tetracyclic diterpenoid from Scoparia dulcis L. Its structure, H+, K+-adenosine triphosphatase inhibitory activity and pharmacokinetic behaviour in rats. (1990)

The structure of scopadulcic acid B (2, SDB), a major ingredient of the Paraguayan herb "Typychá kuratũ" (Scoparia dulcis L.), was elucidated mainly by comparison of its spectral data with that of scopadulcic acid A (1). SDB inhibited both the K(+)-dependent adenosine triphosphatase (ATPase) activity of a hog gastric proton pump (H+, K(+)-ATPase) with a value of 20-30 microM for IC50 and proton transport into gastric vesicles. Pharmacokinetic studies of SDB in rats indicated that plasma SDB concentrations after i.v. injection of the sodium salt of SDB (SDB-Na) were described reasonably well by a two-compartment open model with Michaelis-Menten elimination kinetics. Plasma concentrations after oral administration of SDB-Na or SDB showed a much slower decline than what was expected following the i. v. study. It was suggested that the sustained plasma level of SDB after oral administration of SDB-Na or SDB was accounted for by relatively slow but efficient gastro-intestinal absorption in rats.
Structure-activity relationships of analogs of the endogenous brain peptides Tyr-MIF-1 and Tyr-W-MIF-1. (1993)

Analogs of the naturally occurring peptides Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) and Tyr-W-MIF-1 (Tyr-Pro-Trp-GLy-NH2) were synthesized and investigated for their opiate agonist as well as antagonist activity in the guinea pig ileum assay. [Tyr5]-Tyr-MIF-1 and the endogenous Tyr-W-MIF-1 were the most potent opiate agonists among the 20 compounds tested. Several analogs showed antiopiate activity in the ileum from morphine-tolerant animals as measured by attenuation of the agonistic effect of DAMGO, which inhibits electrically stimulated contractions of the ileum. The binding activity of the analogs at mu opiate receptors was determined by displacement of [3H]-DAMGO in rat brain. Tyr-W-MIF-1 and its analogs were more potent than Tyr-MIF-1 and its analogs in this binding assay. Thus, Tyr-MIF-1, Tyr-W-MIF-1 and several of their analogs could act as opiate agonists as well as antagonists.
Goshuyuto, a Traditional Japanese Medicine for Migraine, Inhibits Platelet Aggregation in Guinea-Pig Whole Blood (2008)

The effects of goshuyuto and chotosan, traditional Japanese medicines, on collagen-induced platelet aggregation were examined using guinea-pig blood. Goshuyuto at the concentration of 1,000 mug/mL inhibited collagen-induced platelet hyper-aggregation to the same degree as aspirin at the concentration of 100 mumol/L, but chotosan did not. Goshuyuto is composed of four medicinal herbs. Of them, aqueous extracts of Evodiae Fructus and Zingiberis Rhizoma inhibited platelet aggregation, but aqueous extracts of Zizyphi Fructus and Ginseng Radix did not. Two components of Zingiberis Rhizoma, 6-shogaol and 6-gingerol, also inhibited platelet aggregation. These results suggest that Evodiae Fructus and Zingiberis Rhizoma may play important roles in the anti-aggregation effects of goshuyuto and that 6-shogaol and 6-gingerol are among the active ingredients. Therefore, goshuyuto may ameliorate migraine by preventing the hyper-aggregation of platelets in migraine with aura.
Leading Behavior of Interest Rate Term Spreads and Credit Risk Spreads in Korea (2012)

Interest rate term spreads and credit spreads have been well known to have a predictive power for future fluctuations of output in many developed countries. This study examines leading behaviors of interest rate term spreads and credit risk spreads in Korea in two ways. First, we apply various empirical methods for finding leading behavior of interest rate term spreads and credit risk spreads in business fluctuations over the period spanning from May 1995 to January 2012. Second, using structural VAR models, we decompose the sources of fluctuations of output and interest rate spreads into two sorts, permanent real shocks and temporary financial shocks and examine the impulse response of each variable to the shocks focusing on the leading behavior of the spreads over the business cycle. We establish successfully the leading behavior of the term spread and the credit risk spread in Korea that the term spread tends to increase and the credit risk spread tends to shrink about 4 to 6 months before an expansion. We also find that much of the output fluctuations are attributed to real shocks while fluctuations in the interest rate spreads come from temporary financial shocks.
Are dopamine antagonists a risk factor for breast cancer? An answer from Parkinson's disease (2003)

Women undergoing chemotherapy for breast cancer are often administered dopamine antagonist adjuvant medications that may increase levels of prolactin potentially increasing the risk of cancer. Using nationwide computerized registers of death data for the years 1991 through 1996 we examined 12,430,473 deaths of persons over 40 years of age and extracted 144,364 cases with Parkinson's disease (PD), a dopamine deficient population. Patients with PD had lower rates of breast and other types of malignancies, even in the presence of depression and suicide.
Implantable Wireless Intraocular Pressure Sensors (2009)

The work in this thesis aims to develop a suite of biomedical microdevice implants, with an intense focus on pressure sensors, for glaucoma study and management featuring the enabling micro-electro-mechanical-system (MEMS) technologies and the use of parylene (poly-para-xylene) as a biocompatible MEMS material. The problems of the debilitating eye disease glaucoma threaten tens of millions of people worldwide with loss of vision, and are not completely resolved using the current non-optimal clinical procedures. Given the relation of neuropathy and the physiological parameter of intraocular pressure (IOP) in glaucoma from clinical findings, such parylene-based MEMS implants are investigated to realize physical IOP monitoring and regulation, and further to accomplish continuous, direct, accurate, reliable, and more effective glaucoma detection and treatment. Miniaturized parylene-based passive pressure sensors are presented in this thesis for IOP monitoring. Complete design, fabrication, characterization, and analysis of such MEMS implants are described to demonstrate their feasibility, covering both engineering and surgical/biological aspects of the proposed applications. Their passive behaviors, based on the comprised micromechanical structures, facilitate unpowered device operations. In addition, such devices are microfabricated in suitable form factors so that minimally invasive suture-less implantation procedures are possible, minimizing time and complexity of the surgeries. Two types of micromachined wireless pressure sensors are developed utilizing optical and electrical sensing methodologies, respectively, to explore the possibility of the proposed implant approach. On-bench experimental results verify that wireless pressure sensing with 1 mmHg accuracy in the 0–100 mmHg range can be achieved using both types of devices. Surgical studies, including ex vivo and in vivo animal tests, confirm the bioefficacy and biostability of the device implants in the intraocular environment. With the attempt of providing implementation concepts of the MEMS implant approaches for ultimate glaucoma study and management in practice, system-level designs and configurations involving such microdevice implants are briefly described as well. Micromachined passive-valved flow-control devices with designed surgical and engineering features are also developed (experimentally achieving 0–100 mmHg and 0–10 uL/min pressure and flow rate regulation ranges) to investigate the feasibility and possibility of such implant approach for unpowered physical IOP regulation in glaucoma treatment.
Antifungal and Antibacterial Metabolites from a Sclerotium-Colonizing Isolate of <i>Mortierella </i><i>v</i><i>inacea</i> (1999)

The known compound methyl 2,4-dihydroxy-3,5,6-trimethylbenzoate (1) and three new related metabolites, which we have named mortivinacins A (2), B (3), and C (4), were identified as metabolites of the fungus Mortierella vinacea. Nicotinic acid (5) was also encountered. This isolate of M. vinacea was obtained from an Aspergillus flavus sclerotium during field studies of sclerotium longevity in soil. Compounds 1-5 were isolated by chromatographic fractionation of organic extracts from M. vinacea solid-substrate fermentation cultures, and the structures were assigned by analysis of NMR and MS data. Compounds 1, 2, and 5 were responsible for the antibacterial and antifungal activities of the extract.
Synthesis and characterization of halogenated derivatives of the ionophore of 5-(methylamino)-2-[[3,9,11-trimethyl-8-[1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid: enhanced calcium ion transport specificity by the 4-bromo derivative (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of halogenated derivatives of the ionophore of 5-(methylamino)-2-[[3,9,11-trimethyl-8-[1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid: enhanced calcium ion transport specificity by the 4-bromo derivativeManuel Debono, R. M. Molloy, D. E. Dorman, J. W. Paschal, Donner F. Babcock, Charles M. Deber, and Douglas R. PfeifferCite this: Biochemistry 1981, 20, 24, 6865–6872Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/bi00527a019https://doi.org/10.1021/bi00527a019research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Shape-based interpolation of multidimensional objects (1990)

A shape-based interpolation scheme for multidimensional images is presented. This scheme consists of first segmenting the given image data into a binary image, converting the binary image back into a gray image wherein the gray value of a point represents its shortest distance (positive value for points of the object and negative for those outside) from the cross-sectional boundary, and then interpolating the gray image. The set of all points with nonnegative values associated with them in the interpolated image constitutes the interpolated object. The method not only minimizes user involvement in interactive segmentation, but also leads to more accurate representation and depiction of dynamic as well as static objects. The general methodology and the implementation details of the method are presented and compared on a qualitative and quantitative basis to the existing methods. The generality of the proposed scheme is illustrated with a number of medical imaging examples.