gebhart/patrepeval huggingface dataset:
A framework for validating distributed real time applications by performance evaluation of communication profiles (2002)

Our general research problem is to provide models or tools helping with the realisation of real time distributed applications. Inside this framework, it is significant and even crucial to take into account in the early stages of system life cycle, performance parameters such as response time or resources load. Performance evaluation of a real-time distributed environment is a difficult task whose results are often subject to criticism because the model relies on approximations based on developer intuition. In this paper we present results concerning the performance evaluation study of a distributed application platform called Cime Computing Environment (CCE), ESPRIT Project no.7096. We explain how we have used a modular and reliable modeling technique and how we have tested each part of the complete model. We have tested the models by comparison with known results of analytical study or measurements experiments. This performance evaluation should help the parameter setting to meet real-time constraints.
Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering (2009)

To identify the genes and molecular functional pathways involved in esophageal cancer, we analyzed the gene expression profile of esophageal tumor tissue from patients having family history of esophageal cancer by cDNA microarray. Three hundred and fifty differentially expressed genes (26 up-regulated and 324 down-regulated) were identified. Genes involved in humoral immune response (PF4), extracellular matrix organization (COL4A4), metabolism of xenobiotics (EPHX1), TGF-beta signaling (SMAD1) and calcium signaling pathways (VDAC1) were down-regulated and genes involved in regulation of actin cytoskeleton (WASL), neuroactive ligand receptor interaction (GRM3), Toll-like receptor (CD14), B-cell receptor (IFITM1) and insulin signaling pathways (FOXO1A) were up-regulated. Validation of differential expression of subset of genes by QRT-PCR and tissue microarray in familial and non-familial cases showed no significant difference in expression of these genes in two groups suggesting familial clustering occurs as result of sharing of common environmental factors. Gene expression profiling of clinical specimens from well characterized populations that have familial clustering of cancer identified molecular mechanism associated with progression of esophageal cancer.
A Prospective Observational Study of Maternal Oxygenation During Remifentanil Patient-controlled Analgesia Use in Labour (2016)

( Anaesthesia 2016;71:171–176) Remifentanil patient-controlled analgesia (PCA) has been used for labor analgesia for many years at some institutions. However, its use has not gained widespread acceptance. Studies have shown high levels of maternal satisfaction with remifentanil PCA for labor, but safety concerns, especially the adverse effects of sedation and respiratory depression, seem to be contributing to the reluctance of many anesthesiologists to adopt this analgesic technique. The objective of this study was to evaluate maternal oxygen desaturation during remifentanil PCA for labor.
Oxidation of N-Acylindoles by Dimethyldioxirane and Singlet Oxygen: Substituent Effects on Thermally Persistent Indole Epoxides and Dioxetanes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of N-Acylindoles by Dimethyldioxirane and Singlet Oxygen: Substituent Effects on Thermally Persistent Indole Epoxides and DioxetanesWaldemar Adam, Michael Ahrweiler, Karl Peters, and Bernd SchmiedeskampCite this: J. Org. Chem. 1994, 59, 10, 2733–2739Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/jo00089a016https://doi.org/10.1021/jo00089a016research-articleACS PublicationsRequest reuse permissionsArticle Views1748Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
“Antedisciplinary” Science (2005)

individual disciplines and explore new organizational models for team science. Advances in molecular imaging, for example, require collaborations among diverse groups-radiologists, cell biologists, physicists, and computer programmers.'' -National Institutes of Health Roadmap Initiative
Selective Inhibition of <i>Trypanosoma brucei</i> 6-Phosphogluconate Dehydrogenase by High-Energy Intermediate and Transition-State Analogues (2004)

Two series of compounds were designed to mimic the transition state and high-energy intermediates (HEI) of the enzymatic reaction of 6-phosphogluconate dehydrogenase (6PGDH). Sulfoxide analogues (7-11) were designed to mimic the transition state during the oxidation of the substrate to 3-keto-6-phosphogluconate, an enzyme-bound intermediate of the enzyme. Hydroxamate and amide derivatives of d-erythronic acid were designed to mimic the 1,2-cis-enediol HEI of the 6PGDH reaction. These two series of compounds were assayed as competitive inhibitors of the Trypanosoma brucei and sheep liver enzymes, and their selectivity value (ratio sheep/parasite) was calculated. The sulfoxide transition-state analogues showed weak and selective inhibition of the T. brucei enzyme. The hydroxamic derivatives showed potent and selective inhibition of the T. brucei 6PGDH with a Ki in the nanomolar range.
Effect of retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness (2015)

<b>Rationale:</b> Retinoid X receptors (RXRs) are members of nuclear receptor (NR) superfamily that mediates signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. RXRs play a key role as heterodimeric partners, e.g., Retinoid acid receptors (RARs), vitamin D receptors (VDRs), and peroxisome proliferator-activated receptors (PPARs). Recently, NR family is reported to associate with allergic diseases, nonetheless the role of RXRs in allergen-induced airway responses is not well defined. <b>Methods:</b> We investigated the effect of novel partial RXR agonist (Net-4IB) on the development of allergic airway inflammation and airway hypperresponsiveness (AHR) in asthma mice model. Balb/c mice were sensitized (days 0 and 14) and challenged (days 28-30) with ovalbumin (OVA), and airway inflammation and airway responses were monitored 48 hours after the last OVA-challenge. Net-4IB was administered orally on days 25 to 32. <b>Result:</b> Oral administration with Net-4IB significantly suppressed AHR, inflammatory cells accumulation in the airways, and attenuated the levels of IL-4, IL-5 and IL-13 in bronchoalveolar lavage fluid and the numbers of PAS positive cells in the lung tissue. <b>Conclusion:</b> These date suggest that Net-4IB may play an important role in the development of allergic airway inflammation and airway hyperresponsiveness in a murine model of asthma.
Role of G<sub>M1 </sub>binding in the mucosal immunogenicity and adjuvant activity of the <i>Escherichia coli</i> heat‐labile enterotoxin and its B subunit (1998)

Escherichia coli (E. coli) heat-labile toxin (LT) is a potent mucosal immunogen and immunoadjuvant towards co-administered antigens. LT is composed of one copy of the A subunit, which has ADP-ribosylation activity, and a homopentamer of B subunits, which has affinity for the toxin receptor, the ganglioside GM1. Both the ADP-ribosylation activity of LTA and GM1 binding of LTB have been proposed to be involved in immune stimulation. We investigated the roles of these activities in the immunogenicity of recombinant LT or LTB upon intranasal immunization of mice using LT/LTB mutants, lacking either ADP-ribosylation activity, GM1-binding affinity, or both. Likewise, the adjuvant properties of these LT/LTB variants towards influenza virus subunit antigen were investigated. With respect to the immunogenicity of LT and LTB, we found that GM1-binding activity is essential for effective induction of anti-LTB antibodies. On the other hand, an LT mutant lacking ADP-ribosylation activity retained the immunogenic properties of the native toxin, indicating that ADP ribosylation is not critically involved. Whereas adjuvanticity of LTB was found to be directly related to GM1-binding activity, adjuvanticity of LT was found to be independent of GM1-binding affinity. Moreover, a mutant lacking both GM1-binding and ADP-ribosylation activity, also retained adjuvanticity. These results demonstrate that neither ADP-ribosylation activity nor GM1 binding are essential for adjuvanticity of LT, and suggest an ADP-ribosylation-independent adjuvant effect of the A subunit.
Serum iron and copper status and oxidative stress in severe and mild preeclampsia (2005)

Our aim was to investigate parameters of iron and copper status and oxidative stress and antioxidant function in women with healthy pregnancy, mild and severe preeclampsia with a view to exploring the possible contribution of these parameters to the aetiology. Thirty healthy, 30 mild preeclamptic and 30 severe preeclamptic pregnant women were included. Serum and placental lipid peroxides, and serum vitamin E and total carotene levels were measured by colorimetric assay. Cholesterol, copper, iron, total iron binding capacity (TIBC), ceruloplasmin and transferrin concentrations were measured by commercially available procedures. Data were analysed statistically using one-way analysis of variance and Pearson correlation test. Logistic regression procedures were used to calculate odds ratios. Lipid peroxides in serum and placental tissue, and iron, copper and ceruloplasmin levels in serum were significantly increased, and transferrin, TIBC, vitamin E/total cholesterol and total carotene/total cholesterol ratios in serum were significantly decreased especially in women with severe preeclampsia. Significant correlations were detected between serum iron and lipid peroxides in serum and placental tissue and between serum iron and vitamin E/total cholesterol in severe preeclamptic pregnancy. Furthermore, there were significant correlations between serum malondialdehyde and ceruloplasmin and vitamin E/total cholesterol in women with severe preeclampsia, and changes in serum and placental lipid peroxides and serum iron concentrations were significantly associated with preeclampsia. In conclusion, ischaemic placental tissue may be a primary source of potentially toxic iron in preeclampsia and the released iron species may contribute to the aetiology and would exacerbate lipid peroxidation and endothelial cell injury, which may be abated by antioxidant supplementation.
THERMAL TRANSFORMATIONS OF UNSATURATED POLY(SILICOHYDROCARBONS) (2001)

Thermolysis of poly(dimethylsilethyne) and poly(dimethylsilethenesilethyne) was studied at temperatures up to 1700°C by the methods of IR and Raman spectroscopy, high-resolution solid-state 13 C NMR spectroscopy, scanning electron microscopy, and thermogravimetric analysis. A continuous evolution of the thermolysis products includes, first, the formation of a silicon carbide phase, crystallization, and β-α transition, and, second, the formation of condensed aromatic structures at the initial stages, the consumption of these groups to accomplish the formation of silicon carbide, and the ordering and subsequent crystallization of carbon phases.
Can Gut Microbiota and Lifestyle Help Us in the Handling of Anorexia Nervosa Patients? (2019)

Gut microbiota is composed of different microorganisms that play an important role in the host. New research shows that bidirectional communications happen between intestinal microbiota and the brain, which is known as the gut⁻brain axis. This communication is significant and could have a negative or positive effect depending on the state of the gut microbiota. Anorexia nervosa (AN) is a mental illness associated with metabolic, immunologic, biochemical, sensory abnormalities, and extremely low body weight. Different studies have shown a dysbiosis in patients with AN. Due to the gut⁻brain axis, it was observed that some of the symptoms could be improved in these patients by boosting their gut microbiota. This paper highlights some evidence connecting the role of microbiota in the AN onset and disease progress. Finally, a proposal is done to include the microbiota analysis as part of the recovery protocol used to treat AN patients. When conducting clinical studies of gut microbiota in AN patients, dysbiosis is expected to be found. Then the prescription of a personalized treatment rich in prebiotics and probiotics could be proposed to reverse the dysbiosis.
Ionic dependence of glycylsarcosine uptake by isolated chicken enterocytes (1989)

Dipeptide transport was studied in chicken enterocytes and its properties compared with those of Na+-dependent sugar transport. Results showed that 1) isolated cells were capable of accumulating glycylsarcosine (Gly-Sar) against a concentration gradient (2.5- to 3.0-fold accumulation). This uptake was maximal at pH 6.0, and it was inhibited by Na+-free medium and by ouabain; 2) uptake of Gly-Sar was not affected by methionine and was competitively inhibited by carnosine, with a Ki of 12 mM; 3) the protonophore FCCP inhibited both Gly-Sar and 3-oxy-methyl-D-glucose (3-OMG) uptake by the cells; 4) amiloride, a well-known inhibitor of the Na+/H+ exchanger system stimulated 3-OMG uptake and inhibited Gly-Sar uptake, its effects being greater at pH 7.4; 5) and monensin prevents the effects of amiloride on both sugar and dipeptide uptake. In summary, Gly-Sar uptake depends on extracellular Na+ in an indirect manner via its effect on H+ efflux, and it appears to be dependent on an inward H+ gradient.
Optical quenching and recovery of photoconductivity in single-crystal diamond (2017)

We study the photocurrent induced by pulsed-light illumination (pulse duration is several nanoseconds) of single-crystal diamond containing nitrogen impurities. Application of additional continuous-wave light of the same wavelength quenches pulsed photocurrent. Characterization of the optically quenched photocurrent and its recovery is important for the development of diamond based electronics and sensing.
<i>N</i>-Heterocyclic Carbene-Catalyzed Conjugate Additions of Alcohols (2010)

An efficient intermolecular conjugate addition of alcohols to activated alkenes catalyzed by N-heterocyclic carbenes has been developed. With 5 mol % of the free carbene derived from IMes·HCl, unsaturated ketones and esters are competent substrates, and a variety of primary and secondary alcohols can be employed as the nucleophile. No oligomerization is observed under these mild conditions for effective hydroalkoxylation. In addition to reactions with activated alkenes, IMes catalyzes the formation of vinyl ethers through the 1,4-addition of alcohols to ynones and promotes tandem conjugate addition/Michael cascade reactions. Preliminary data support a Brønsted base mechanism with the free carbene.
Phenotypic similarity between T-cell antigen binding molecules. (1986)

T-cell antigen binding molecules (TABM) specific for trinitrophenol (TNP), oxazalone, azobenzenearsonate or sheep erythrocytes were purified by affinity to antigen, adsorption to monoclonal antibodies to antigen binding molecules or were synthesized by translation of immunopurified mRNA for TABM in vitro. These molecules and a T-cell line, BW5147, membrane protein bound by rabbit antibodies to TABM were radiolabeled by 125I, digested with Staphylococcus V8 protease, and peptides of the proteolytic digest were resolved by 2D-gel peptide mapping. Comparison of the peptide maps of these proteins and amino acid analysis of T-cell antigen binding molecules specific for TNP or sheep erythrocytes indicate similarities and distinctions suggesting variable and constant domains in these molecules.
Analysis of cyclin D1 and CDK expression in colonic polyps containing neoplastic foci: A study of proteins extracted from paraffin sections (2002)

Overexpression or amplification of G1 cyclins has been demonstrated in various types of human cancers. Overexpression of cyclin D1, an accelerator of cell cycle, is thought to be an early event in colonic multistage carcinogenesis, but its expression at transformation from benign to neoplastic foci is not clear. We analyzed the expression of cyclin D1 and its catalystic partner CDK4 in colon polyps containing neoplastic foci. For direct comparison of the expression in adenomatous tissues and neoplastic foci, proteins in adequate amounts were extracted from paraffin embedded sections. Western blot and densitometry analyses showed that cyclin D1 expression was 2.3-times and 2.5-times higher in adenomatous tissues and neoplastic foci, compared with normal colonic mucosa. In contrast, the levels of CDK4 and CDK2 expression were only modestly increased in adenomatous tissues but significantly higher in neoplastic foci, relative to normal mucosa. Expression of PCNA, a cell proliferation marker, increased from normal mucosa to adenoma to focal cancer. Our findings suggest that overexpression of cyclin D1 may be associated with high proliferative activity in adenomatous tissues and that concurrent high expression of cyclin D1 and CDK4 may further perturb cell cycle progression and play a pivotal role in colonic carcinogenesis.
Multiplication of cellular radio capacity by blind adaptive spatial filtering (2003)

A scheme for cellular radio which greatly increases the allowable number of simultaneous users in each cell is proposed. The scheme employs space-division multiplexing by means of an adaptive antenna array at the base station (1) to separate the temporally and spectrally overlapping signals of users that arrive from different locations within the cell and to mitigate multipath fading and shadowing at the base station and (2) by reciprocity to transmit directively to minimize interfering signals arriving at the mobile units and to mitigate multipath fading and shadowing at the mobile units. A novel aspect of the proposed scheme is that no training signals are required for adaptation, nor are computationally intensive direction-finding methods required, nor is any calibration data required for the array. Results from computer simulations on the performance of the new scheme show that the proposed scheme can accommodate up to five times as many users as a proposed CDMA scheme using the same system bandwidth.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Aspects of biotechnological production of food flavors (1989)

Abstract Three principle technologies and their potential application for bioflavor production are discussed: (i) plant tissue and cell culture, (ii) use of microorganisms, and (iii) use of enzymes. Plant cell and tissue cultures have been received by scientists with great enthusiasm; however, we have now to realize that much more must be learned about chemical and genetic regulation of plant secondary metabolism before any commercial production becomes a reality. Fermentations and microbial transformations are already used in flavor production and there is no doubt that these technologies will become more significant factors in the production of flavor chemicals in the future. As to enzymes, technical biocatalysts already play a role in stereoselective production of fine chemicals. Regarding natural flavors, we have to intensify our studies on biochemistry and bioregulation of enzymic activities from both plants and microorganisms. If this is done, the use of enzymes for the production of complete natural flavors will be realized in the future.
Effect of Cenospheres on Flyash Brick Properties (2007)

In January 2006, the National Science Foundation awarded Freight Pipeline Company (FPC) with a Small Business Innovation Research (SBIR) Phase II grant. This grant enabled FPC to continue testing the durable 100% flyash brick developed during Phase I, in an effort to achieve commercialization by 2008. Under this research, cenospheres were evaluated to determine their usefulness as an additive to flyash to improve the brick’s properties.
Linkage of otosclerosis to a third locus (<i>OTSC3</i>) on human chromosome 6p21.3-22.3 (2002)

Clinical otosclerosis (OMIM 166800/605727) has a prevalence of 0.2-1% among white adults, making it the single most common cause of hearing impairment in this group. It is caused by abnormal bone homeostasis of the otic capsule with the consequent development of sclerotic foci that invade the stapedio-vestibular joint (oval window) interfering with free motion of the stapes. Impaired ossicular chain mobility results in a conductive hearing loss. We identified the first locus for otosclerosis (OTSC1) on chromosome 15 in 1998 and reported a second locus (OTSC2) on chromosome 7 last year. Here we present results of a genome wide linkage study on a large Cypriot family segregating otosclerosis. Results of this study exclude linkage to OTSC1 and OTSC2 and identify a third locus, OTSC3, on chromosome 6p. The defined OTSC3 interval covers the HLA region, consistent with reported associations between HLA-A/HLA-B antigens and otosclerosis.