gebhart/patrepeval huggingface dataset:
Identification of a major prolactin-regulated protein as 20 alpha-hydroxysteroid dehydrogenase: coordinate regulation of its activity, protein content, and messenger ribonucleic acid expression. (1994)

We have previously reported that an abundant 37,000 mol wt protein with a pI of 6.15 (37K) is expressed specifically in the corpus luteum and is markedly inhibited by PRL. To identify the 37K, amino acid sequence analysis of the protein was performed. The 37K protein showed sequence similarity with rabbit 20 alpha-hydroxysteroid dehydrogenase (20 alpha HSD), chlordecone reductase, prostaglandin synthase, and 3 alpha-hydroxysteroid dehydrogenase, which are members of the aldo-keto reductase group of enzymes that catalyze the NADPH-dependent reduction of carbonyl compounds. Comparison of 20 alpha HSD activity with the level of 37K in the corpus luteum throughout pregnancy demonstrated a close correlation between enzyme activity and luteal levels of the protein. Both protein and enzyme activity were low early in pregnancy, reached a nadir between days 5-19, and reappeared abruptly between days 19-21 of pregnancy. To establish that the enzyme activity is intrinsic to the 37K, the protein was purified from sodium dodecyl sulfate-polyacrylamide electrophoresis gels (SDS-PAGE), renatured, and assayed for 20 alpha HSD activity. The renatured protein exhibited substantial 20 alpha HSD activity. As 20 alpha HSD is known to play a major role in the termination of pregnancy in the rat, it was of interest to examine whether the rapid appearance of the 37 K protein at the end of pregnancy is accompanied by the induction of 20 alpha HSD gene expression. Northern blot analysis using a rabbit cDNA for 20 alpha HSD indicated that the pattern of 20 alpha HSD mRNA expression in the corpus luteum closely paralleled the ontogeny of 20 alpha HSD enzyme activity as well as 37K protein levels. Our studies demonstrated that 20 alpha HSD protein and mRNA levels are coordinately regulated, and that the profound inhibitory effect of PRL on 20 alpha HSD activity is apparently due to inhibition of 20 alpha HSD gene expression, leading to the disappearance of the protein from the corpus luteum.
A comparison of disk drives for enterprise computing (2006)

For end users, the five most externally visible characteristics of a disk drive are capacity, price, interface type (e.g. SCSI, ATA, Fibre Channel, SATA), performance (e.g. access time, I/Os per second, sustained transfer rate) and reliability (e.g. MTBF or unrecoverable read error rate). 
When evaluating a drive for a particular application, these attributes carry varying weight. We'll examine how these attibutes are related in real disk drive implementations, what applications are best suited to specific drive types, and what the future holds for disk storage in the enterprise.
The Effect of Selenium Therapy on Mortality in Patients With Sepsis Syndrome (2013)

In patients with sepsis, selenium supplementation at doses higher than daily requirement may reduce mortality. We observed no impact of selenium on ICU length of stay or risk of nosocomial pneumonia.
Synthesis and Chemistry of some Novel 3-Heteroaryl-quinazolin-4-one Derivatives and their Antimicrobial Effects (1997)

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt <em>Manuscript received 6 March 1995, revised 18 March 1996, accepted 24 July 1996</em> Some new heteroaryl-quinazolin-4-ones have been synthesised via the interaction of 3-amino-2-phenyl-6-iodoquinazolin-4-one with some oxo-compounds. Significant <em>in vitro</em> antimicrobial activities have been observed for some members of the series.
Analysis of mechanisms underlying EDS1-PAD4 cooperation in Arabidopsis immune signaling (2007)

Plants have evolved a multilayered immune system to counter pathogen attacks. EDS1 (Enhanced Disease Susceptibility 1) and PAD4 (Phytoalexin Deficient 4) are two plant- specific lipase-like proteins that function as essential regulators of plant innate immunity. They are crucial for basal defence that restricts growth of virulent pathogens and for race-specific resistance to avirulent pathogens triggered by TIR (Toll-Interleukin 1) type NBS-LRR (Nucleotide Binding Site � Leucine Rich Repeats) immune receptors. Moreover, EDS1 and PAD4 generate and perceive (a) signal(s) needed to induce systemic immunity. These regulators stimulate accumulation of the phenolic defence signaling molecule salicylic acid (SA) and SA, in turn, induces their expression creating a positive feedback loop in defence potentiation. EDS1 and PAD4 transcript and correspondent protein levels increase upon pathogen challenge. However, earlier changes in expression of a set of distinct genes which are EDS1- and PAD4-dependent imply the activation of pre-existing EDS1/PAD4 complexes through post-translational mechanism(s). In this work I investigated the relative importance of transcriptional regulation and post-transcriptional processes for EDS1 and PAD4 protein functions. I characterized Arabidopsis thaliana transgenic lines overexpressing either EDS1, PAD4 or both. Only lines cooverexpressing EDS1 and PAD exhibited growth retardation associated with constitutive activation of the SA pathway and increased resistance to virulent pathogens resulting from a faster SA pathway activation. These lines exhibit also increased tolerance to chemically induced oxidative stress consistent with a known role of EDS1 and PAD4 in processing reactive oxygen species (ROS) - derived signals. The insufficiency of EDS1-PAD4 cooverexpression to fully recapitulate defence activation implies the existence of post-translational mechanisms of regulation. The existence of regulatory post-translational modifications of the EDS1 protein was investigated and lines expressing constitutively or conditionally activated functional epitope-tagged EDS1 were generated. The data presented here demonstrate that EDS1 and PAD4 operate as a signaling unit. The basis of the observed dramatic biotic and abiotic stress phenotypes will be further investigated as it should provide important insight into EDS1 and PAD4 functions.
Elementary Preservice Teachers' Knowledge and Beliefs Regarding Science and Mathematics (1996)

The development of teacher education programs to better prepare elementary teachers requires an empirical base in which to anchor meaningful change. The research reported herein makes just such an effort. Preservice teachers' mathematics and science knowledge was measured as were their beliefs regarding instruction in these content areas. The results suggest that an increase in the number of college credit hours in science and mathematics content is less likely to effect necessary change than alteration of the methods and curriculum materials.
Programa de intervención "ruptura de pareja, no de familia" con familias inmersas en procesos de separación (2002)

The position of on-body motion sensors plays an important role in human activity recognition. Most often, mobile phone sensors at the trouser pocket or an equivalent position are used for this purpose. However, this position is not suitable for recognizing activities that involve hand gestures, such as smoking, eating, drinking coffee and giving a talk. To recognize such activities, wrist-worn motion sensors are used. However, these two positions are mainly used in isolation. To use richer context information, we evaluate three motion sensors (accelerometer, gyroscope and linear acceleration sensor) at both wrist and pocket positions. Using three classifiers, we show that the combination of these two positions outperforms the wrist position alone, mainly at smaller segmentation windows. Another problem is that less-repetitive activities, such as smoking, eating, giving a talk and drinking coffee, cannot be recognized easily at smaller segmentation windows unlike repetitive activities, like walking, jogging and biking. For this purpose, we evaluate the effect of seven window sizes (2-30 s) on thirteen activities and show how increasing window size affects these various activities in different ways. We also propose various optimizations to further improve the recognition of these activities. For reproducibility, we make our dataset publicly available.
Modulation of Minute Virus of Mice Cytotoxic Activities through Site-Directed Mutagenesis within the NS Coding Region (2003)

Late in infection, parvovirus minute virus of mice (MVMp) induces the lysis of mouse A9 fibroblasts. This effect depends on the large nonstructural phosphoprotein NS1, which plays in addition a major role in viral DNA replication and progeny particle production. Since the NS1 C-terminal region is subjected to late phosphorylation events and protein kinase C (PKC) family members regulate NS1 replicative activities, the present study was conducted to determine the impact of PKCs on NS1 cytotoxic functions. To this end, we performed site-directed mutagenesis, substituting alanine residues for two consensus PKC-phosphorylation sites located within the NS1 C-terminal region, T585 and S588. Although these substitutions had no detectable effect on virus multiplication in a single-round infection, the NS1-585A mutant virus was significantly less toxic to A9 cells than wild-type MVMp, whereas the NS1-588A mutant virus was endowed with a higher killing potential. These alterations correlated with specific changes in the late phosphorylation pattern of the mutant NS1 proteins compared to the wild-type polypeptide. Since the mutations introduced in this region of the viral genome also made changes in the minor nonstructural protein NS2, a contribution of this polypeptide to the above-mentioned phenotypes of mutant viruses cannot be excluded at present. However, the involvement of NS1 in these phenotypes was directly supported by the respective reduced and enhanced capacity of NS1-585A and NS1-588A recombinant proteins for inducing morphological alterations and cell detachment in transfected A9 cultures. Altogether, these data suggest that late-occurring phosphorylation of NS1 specifically regulates the cytotoxic functions of the viral product and that residues T585 and S588 contribute to this control in an antagonistic way.
Kinetics of the attack of refractory solids by atomic and molecular fluorine (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of the attack of refractory solids by atomic and molecular fluorineDaniel E. Rosner and H. Donald AllendorfCite this: J. Phys. Chem. 1971, 75, 3, 308–317Publication Date (Print):February 1, 1971Publication History Published online1 May 2002Published inissue 1 February 1971https://pubs.acs.org/doi/10.1021/j100673a003https://doi.org/10.1021/j100673a003research-articleACS PublicationsRequest reuse permissionsArticle Views121Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
E. D. Phillips: The Mongols. (Ancient Peoples and Places, Vol. 64.) 208 pp. London: Thames and Hudson, 1969. 42<i>s</i>. (1969)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Optimal management of septic shock (2002)

Septic shock is a common problem in hospitalized patients. Optimal management depends on rapid recognition, aggressive restoration of circulating volume with fluid boluses, initiation of appropriate antibiotic therapy, implementation of adequate monitoring, and meticulous attention to the details of care. Mean arterial pressure should be increased to between 65 and 75 mm Hg as soon as possible to reduce the likelihood of multiorgan dysfunction. Despite these therapeutic maneuvers, however, mortality rates are likely to remain high until the development of therapies that better target the underlying mechanisms of sepsis.
Two selective inhibitors of cholinesterase (1953)

Research Article| July 01 1953 Two selective inhibitors of cholinesterase L. Austin; L. Austin * 1Chemical Defence Experimental Establishment, Porton, Wilts Search for other works by this author on: This Site PubMed Google Scholar W. K. Berry W. K. Berry 1Chemical Defence Experimental Establishment, Porton, Wilts Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1953) 54 (4): 695–700. https://doi.org/10.1042/bj0540695 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation L. Austin, W. K. Berry; Two selective inhibitors of cholinesterase. Biochem J 1 July 1953; 54 (4): 695–700. doi: https://doi.org/10.1042/bj0540695 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1953 CAMBRIDGE UNIVERSITY PRESS1953 Article PDF first page preview Close Modal You do not currently have access to this content.
Arbitrary control of the free spectral range of periodic optical frequency combs through linear energy-preserving time-frequency Talbot effects (2016)

We present a lossless technique to multiply or divide the free spectral range of an optical coherent frequency comb by any desired integer or fractional factor, entirely based on linear phase manipulations. We experimentally demonstrate this principle on a mode-locked laser-generated comb.
Assessment of Directional Wave Climate Variability for a Sand Bypassing Project (1997)

The assessment of sediment transport characteristics for a proposed permanent sand bypassing system at the Tweed River entrance has necessitated the development of a reliable directional wave climate for the region. Although approximately 20 years of continuous wave observations were available, the lack of long term directional wave data required the incorporation of additional wave direction information. This paper discusses the formulation of a time series of wave parameters for a period of over 7 years between 1989 and 1996. Where both sea and swell wave components coexisted, their parameters were analysed separately. The variability of the wave conditions relating to the implementation of the sand bypassing system are examined on a seasonal basis and over a longer term of approximately 20 years.
Synthesis, Biological Activity, and X‐Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl Acyl Carrier Protein Reductase. Part 1. 4′‐Substituted Triclosan Derivatives. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.
Correlation properties of the ring laser with backscattering (1985)

The equations of motion of the bidirectional ring laser with both spontaneous emission fluctuations and backscattering have been investigated, partly analytically, but mainly by a Monte Carlo technique. The light intensities of the two modes, the phase difference, and the autocorrelation and cross-correlation functions were calculated. The kind of behavior exhibited by the laser is found to depend critically on the phases of the backscattered fields. Some values lead to positive cross correlations in the region where the laser ordinarily exhibits zero or negative correlations, and others to negative cross correlations. When the phases of the two modes are not locked together they undergo random jumps in integer multiples of 2π. The results of the calculations are compared with experimental results from which some conclusions about the backscattering can be drawn.
Automatic Glare Detection via Photometric, Geometric, and Global Positioning Information (2017)

Glare due to sunlight, moonlight, or other light sources can be a serious impediment during autonomous or manual driving. Automatically detecting the presence, location, and severity of such glare can be of critical importance for an autonomous driving system, which may then give greater priority to other sensors or cues/parts of the scene. We present an algorithm for automatic real-time glare detection that uses a combination of: (1) the intensity, saturation, and local contrast of the input frame; (2) shape detection; and (3) solar azimuth and elevation computed based on the position and heading information from the GPS (used under daylight conditions). These data are used to generate a glare occurrence map that indicates the center location(s) and extent(s) of the glare region(s). Testing on a variety of daytime and nighttime scenes demonstrates that the proposed system is effective at glare detection and is capable of real-time operation.
A robust 6 kb/s low delay speech coder for mobile communication (2002)

We propose a low delay speech coder operating at 6 kb/s bit rate in which 4.4 kb/s bit rate is assigned for the low delay speech coding algorithm and 1.6 kb/s bit rate for the error correction algorithm. The main features of the speech coding include the backward short term prediction, the "dual-decision" scheme, and the joint excitation codebook. The forward error correction (FEC) technique is adopted to protect the parameters which need be transmitted in the channel. The proposed coder provides good reconstructed speech quality and is robust to channel errors, while having the coding delay about 2.5 ms only.
Optimal Joint Resource Allocation and Power Control in Bidirectional Relaying Networks (2014)

Cooperative relaying (CoR) and network coding (NC) are two promising techniques for improving the performance of next-generation mobile networks. In this paper, a dynamic joint resource allocation and power control scheme is proposed for bidirectional relaying in wireless mobile networks. We consider a bidirectional relaying network consisting of three nodes: user equipment (UE), base station or eNodeB (eNB), and an intermediate relay station (RS). We model the network by a two-way relay channel (TWRC) in which UE and eNB can choose between different transmission schemes: direct transmission, pure CoR (CoR scheme), or via the combination of NC and CoR (NC/CoR scheme). We first study the achievable rate regions for direct transmission, CoR, and NC/CoR and characterize them by a set of linear inequalities. We show that NC/CoR does not always achieve better performance than CoR or direct transmission in terms of achievable throughput. Therefore, we propose a hybrid transmission scheme with adaptive resource allocation to dynamically choose the best transmission strategy and the optimal resource allocation at each bidirectional transmission time frame. This is done on the basis of the system channel state information and the buffer occupancy of UE and eNB. The hybrid approach achieves the convex hull of the union of the rate regions of the direct, CoR, and NC/CoR schemes. Finally, we extend our hybrid approach by considering power control at the RS, and we use simulations to study the effect of power control in the hybrid scheme. It is shown that in both single-input-single-output and multiple-input-multiple-output systems, the hybrid scheme with joint power control and resource allocation improves the throughput and delay performance of the system considerably.
Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers (2013)

Tuberculosis and sarcoidosis revealed similar blood transcriptional profiles, dominated by interferon-inducible transcripts, while pneumonia and lung cancer showed distinct signatures, dominated by inflammatory genes. There were also significant differences between tuberculosis and sarcoidosis in the degree of their transcriptional activity, the heterogeneity of their profiles and their transcriptional response to treatment.
Chemical stability of the antitumor drug mitomycin C in solutions for intravesical instillation. (1991)

The chemical stability of the antitumor drug mitomycin C has been investigated by using a stability indicating high performance liquid chromatographic assay. The stability tests were performed in different media and under different conditions which are important for the clinical urology practice in the intravesical chemotherapeutic treatment of superficial bladder cancer. It is concluded that mitomycin C can be dissolved in Water for Injection to a concentration of 30 or 40 mg/50 mL. These solutions are stable for four days at ambient temperature and in the dark. Storage of solutions with a concentration of 30 mg/50 mL are stable for four days in the refrigerator but higher concentrations show precipitation after one day storage at 4 degrees C. Dissolution and storage in 0.9% sodium chloride solution or phosphate buffer pH 7.4 is not recommended because in these, media degradation and/or precipitation occur.
Decentralized fountain codes for minimum-delay data collection (2008)

This paper studies decentralized strategies for facilitating data collection in circular wireless sensor networks, which rely on the stochastic diversity of data storage. The goal is to allow for a reduced delay collection by a mobile data collector (MDC) who accesses the network at a random position and random time. We consider a two-phase data collection: the push phase is mechanized through source packet dissemination strategies based on network coding; the pull phase is based on polling of additional packets from their original source nodes. Dissemination is performed by a set of relays which form a circular route to exchange source packets. The storage nodes within the transmission range of the routeiquests relays linearly combine and store overheard relay transmissions. MDC first collects a set of packets in its physical proximity and, using a message-passing decoder, attempts recovering all original source packets from this set. Whenever the decoder stalls a source packet which restarts decoding is polled/doped from its original source. The number of doped packets can be surprisingly small and, hence, the push-pull doping strategy may have the least collection delay when the density of source nodes is sufficiently large. Furthermore, the Ideal Soliton fountain encoding is a good linear combining strategy at the storage nodes whenever doping is employed.