gebhart/patrepeval huggingface dataset:
Toxicology of the Liver (1998)

1. Drug-induced Hepatic Disease Hyman Zimmerman 2. Morphological Characteristics of Chemical-induced Hepatotoxicity in Laboratory Rodents Paul Newberne and James Newberne 3. Chemical Induced Hepatocarcinogenesis James Klaunig and Kyle Kolaja 4. An Overview of Peroxisome Proliferation Jeffrey Lawrence and Patrick Eacho 5. Acetaminophen-induced Hepatotoxicity Steven Cohen, Debie Hoivik and Edward Khairallah 6. Evaluation of Chemical-induced Oxidative Stress as a Mechanism of Hepatocyte Death Donald Reed 7. Lipid Peroxidation as a Mediator of Chemical-induced Hepatocyte Death Mario Comporti 8. Immunologic Meditation of Chemical-induced Hepatotoxicity Sylvia Furst Jay Gandolfi 9. The Role of Nonpharenchymal Cells and Inflammatory Macrophages in Hepatotoxicity Debra Laskin and Carol Gardner 10. Cholestatic Properties of Steroid Glucuronides Mary Vore and Kim Brouwer 11. Mechanisms Involved in Bile Acid-induced Cholestasis Ibrahim Yousef, Guylaine Bouchard, Beatriz Tuchweber and Gabriel Plaa 12. Cholestasis Produced by Combinations of Manganese and Bilirubin Gabriel Plaa, Alexandra Duguay, Lena King and William Hewitt 13. Evaluation of Chemical-induced Bile Duct Proliferation Claude Barriault, Alexis Desmouliere, Andrea Monte Alto Costa, Ibrahim Yousef and Beatriz Tuchweber. Guylaine Bouchard, University of Montreal, Canada, Kim Brouwer, University of North Carolina, USA, Steven Cohen, University of Connecticut, USA, Mario Comporti, University of Siena, Italy, Andrea Monte Alto Costa, Universidade do Estado do Rio de Janeiro, Brazil, Alexis Desmouliere, Institut de Biologie et Chimie des Proteines, France, Alexandra Duguay, University of Montreal, Canada, Patrick Eacho, Lilly Research Laboritories, USA, Sylvia Furst, Boehringer Ingelheim Pharmaceuticals, USA, Jay Gandolfi, University of Arizona, USA, Carol Gardner, Rutgers University, USA, William Hewitt, SmithKline Beecham Pharmaceuticals, USA, Debie Hoivik, Texas A&M University, USA, Edward Khairallah, Deceased, Lena King, Parke Davis Research Institute, Canada, James Klaunig, Indiana University School of Medicine, USA, Kyle Kolaja, Indiana University School of Medicine, USA, Debra Laskin, Rutgers University, USA, Jeffrey Lawrence, Merck Research Laboratories, USA, James Newberne, University of Cincinatti, USA, Paul Newberne, Boston University School of Medicine, USA, Gabriel Plaa, University of Montreal, Canada, Donald Reed, Oregan State University, USA, Beatriz Tuchweber, University of Montreal, Canada, Mary Vore, University of Kentucky, USA, Ibrahim Yousef, University of Montreal, Canada, Hyman Zimmerman, George Washington University, USA.
Appearance Preserving Rendering of Out-of-Core Polygon and NURBS Models (2005)

In Computer Aided Design (CAD) trimmed NURBS surfaces are widely used due to their flexibility. For rendering and simulation however, piecewise linear representations of these objects are required. A relatively new field in CAD is the analysis of long-term strain tests. After such a test the object is scanned with a 3d laser scanner for further processing on a PC. In all these areas of CAD the number of primitives as well as their complexity has grown constantly in the recent years. This growth is exceeding the increase of processor speed and memory size by far and posing the need for fast out-of-core algorithms. This thesis describes a processing pipeline from the input data in the form of triangular or trimmed NURBS models until the interactive rendering of these models at high visual quality. After discussing the motivation for this work and introducing basic concepts on complex polygon and NURBS models, the second part of this thesis starts with a review of existing simplification and tessellation algorithms. Additionally, an improved stitching algorithm to generate a consistent model after tessellation of a trimmed NURBS model is presented. Since surfaces need to be modified interactively during the design phase, a novel trimmed NURBS rendering algorithm is presented. This algorithm removes the bottleneck of generating and transmitting a new tessellation to the graphics card after each modification of a surface by evaluating and trimming the surface on the GPU. To achieve high visual quality, the appearance of a surface can be preserved using texture mapping. Therefore, a texture mapping algorithm for trimmed NURBS surfaces is presented. To reduce the memory requirements for the textures, the algorithm is modified to generate compressed normal maps to preserve the shading of the original surface. Since texturing is only possible, when a parametric mapping of the surface - requiring additional memory - is available, a new simplification and tessellation error measure is introduced that preserves the appearance of the original surface by controlling the deviation of normal vectors. The preservation of normals and possibly other surface attributes allows interactive visualization for quality control applications (e.g. isophotes and reflection lines). In the last part out-of-core techniques for processing and rendering of gigabyte-sized polygonal and trimmed NURBS models are presented. Then the modifications necessary to support streaming of simplified geometry from a central server are discussed and finally and LOD selection algorithm to support interactive rendering of hard and soft shadows is described.
A Study of Social Behavior Patterns in Moose of Wyoming (1956)

In the framework of a long range comparative study of social behavior in free-living wild ungulates, the Wyoming moose, Alces alces shirasi, is being investigated. This study follows similar methods as our study of Wapiti behavior. Project Number 77.
DMS-prefiltered mass spectrometry for the detection of biomarkers (2008)

Technologies based on Differential Mobility Spectrometry (DMS) are ideally matched to rapid, sensitive, and selective detection of chemicals like biomarkers. Biomarkers linked to exposure to radiation, exposure to CWA's, exposure to toxic materials (TICs and TIMs) and to specific diseases are being examined in a number of laboratories. Screening for these types of exposure can be improved in accuracy and greatly speeded up by using DMS-MS instead of slower techniques like LC-MS and GC-MS. We have performed an extensive series of tests with nanospray-DMS-mass spectroscopy and standalone nanospray-DMS obtaining extensive information on chemistry and detectivity. DMS-MS systems implemented with low-resolution, low-cost, portable mass-spectrometry systems are very promising. Lowresolution mass spectrometry alone would be inadequate for the task, but with DMS pre-filtration to suppress interferences, can be quite effective, even for quantitative measurement. Bio-fluids and digests are well suited to ionization by electrospray and detection by mass-spectrometry, but signals from critical markers are overwhelmed by chemical noise from unrelated species, making essential quantitative analysis impossible. Sionex and collaborators have presented data using DMS to suppress chemical noise, allowing detection of cancer biomarkers in 10,000-fold excess of normal products<sup>1,2</sup>. In addition, a linear dynamic range of approximately 2,000 has been demonstrated with accurate quantitation<sup>3</sup>. We will review the range of possible applications and present new data on DMS-MS biomarker detection.
Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5 (2012)

Significant challenges remain in our ability to convert fibroblasts into cardiomyocyte-like cells and a greater understanding of cardiovascular epigenetics is needed to increase the translational potential of this strategy.
Development of Double-Stranded siRNA Labeling Method Using Positron Emitter and Its In Vivo Trafficking Analyzed by Positron Emission Tomography (2010)

Pharmacokinetic study of small interfering RNA (siRNA) is an important issue for the development of siRNAs for use as a medicine. For this purpose, a novel and favorable positron emitter-labeled siRNA was prepared by amino group-modification using N-succinimidyl 4-[fluorine-18] fluorobenzoate ([(18)F]SFB), and real-time analysis of siRNA trafficking was performed by using positron emission tomography (PET). Naked [(18)F]-labeled siRNA or cationic liposome/[(18)F]-labeled siRNA complexes were administered to mice, and differential biodistribution of the label was imaged by PET. The former was cleared quite rapidly from the bloodstream and excreted from the kidneys; but in contrast, the latter tended to accumulate in the lungs. We also confirmed the biodistribution of fluorescence-labeled naked siRNA and cationic liposome/siRNA complexes by use of a near-infrared fluorescence imaging system. As a result, a similar biodistribution was observed, although quantitative data were obtained only by planar positron imaging system (PPIS) analysis but not by fluorescence in vivo imaging. Our results indicate that PET imaging of siRNA provides important information for the development of siRNA medicines.
Review: <i>General Biology</i>, by Willis H. Johnson, Richard A. Laubengayer, and Louis E. DeLanney (1961)

Book Review| December 01 1961 Review: General Biology, by Willis H. Johnson, Richard A. Laubengayer, and Louis E. DeLanney General BiologyWillis H. JohnsonRichard A. LaubengayerLouis E. DeLanney P. K. P. K. Search for other works by this author on: This Site PubMed Google Scholar The American Biology Teacher (1961) 23 (8): 525–526. https://doi.org/10.2307/4439744 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation P. K.; Review: General Biology, by Willis H. Johnson, Richard A. Laubengayer, and Louis E. DeLanney. The American Biology Teacher 1 December 1961; 23 (8): 525–526. doi: https://doi.org/10.2307/4439744 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Biology Teacher Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
Probiotic Mixture KF Attenuates Age-Dependent Memory Deficit and Lipidemia in Fischer 344 Rats (2015)

To investigate the memory-enhancing effect of lactic acid bacteria, we selected the probiotic mixture KF, which consisted of Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (1 × 10(11) CFU/g of each strain), and investigated its antilipidemic and memoryenhancing effects in aged Fischer 344 rats. KF (1 × 10(10) CFU/rat/day), which was administered orally once a day (6 days per week) for 8 weeks, significantly inhibited age-dependent increases of blood triglyceride and reductions of HDL cholesterol (p < 0.05). KF restored agereduced spontaneous alternation in the Y-maze task to 94.4% of that seen in young rats (p < 0.05). KF treatment slightly, but not significantly, shortened the escape latency daily for 4 days. Oral administration of KF restored age-suppressed doublecortin and brain-derived neurotrophic factor expression in aged rats. Orally administered KF suppressed the expression of p16, p53, and cyclooxygenase-2, the phosphorylation of Akt and mTOR, and the activation of NF-κB in the hippocampus of the brain. These findings suggest that KF may ameliorate age-dependent memory deficit and lipidemia by inhibiting NF-κB activation.
Cutting Edge: A Role for the Adaptor Protein LAT in Human NK Cell-Mediated Cytotoxicity (1999)

Stimulation of NK cell-mediated cytotoxicity involves the coupling of proximal Src and Syk family protein tyrosine kinases to downstream effectors. However, the mechanisms linking these second messenger pathways are incompletely understood. Here, we describe a key role for the LAT (p36) adaptor protein in human NK cell activation. LAT is tyrosine phosphorylated upon stimulation of NK cells through FcgammaRIII receptors and following direct contact with NK-sensitive target cells. This NK stimulation induces the association of LAT with several phosphotyrosine-containing proteins. In addition to the biochemical evidence showing LAT involvement in NK cell activation, a genetic model shows that LAT is required for FcR-dependent phosphorylation of phospholipase C-gamma. Furthermore, overexpression of LAT in NK cells leads to increased Ab-dependent cell-mediated cytotoxicity and "natural cytotoxicity," thus demonstrating a functional role for LAT in NK cells. These data suggest that LAT is an important adaptor protein for the regulation of human NK cell-mediated cytotoxicity.
On dual field measurements using geohydrophones (1994)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1994On dual field measurements using geohydrophonesAuthors: Dan LoewenthalDan LoewenthalTel‐Aviv University, Israelhttps://doi.org/10.1190/1.1932023 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1932023FiguresReferencesRelatedDetailsCited ByMigration of primaries and multiples using an imaging condition for amplitude-normalized separated wavefieldsAlba Ordoñez, Walter Söllner, Tilman Klüver, and Leiv J. Gelius21 August 2014 | GEOPHYSICS, Vol. 79, No. 5Wavefield-separation methods for dual-sensor towed-streamer dataAnthony Day, Tilman Klüver, Walter Söllner, Hocine Tabti, and David Carlson20 March 2013 | GEOPHYSICS, Vol. 78, No. 2 SEG Technical Program Expanded Abstracts 1994ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1994 Pages: 1679 publication data© 1994 Copyright © 1994 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Dan Loewenthal, (1994), "On dual field measurements using geohydrophones," SEG Technical Program Expanded Abstracts : 861-864. https://doi.org/10.1190/1.1932023 Plain-Language Summary PDF DownloadLoading ...
Memory Latency Reduction with Fine-grain Migrating Threads in Numa Shared-memory Multiprocessors. (2002)

In order to fully realize the potential performance benefits of large-scale NUMA shared memory multiprocessors, efficient techniques to reduce/tolerate long memory access latencies in such systems are to be developed. This paper discusses the concept, software and hardware support for memory latency reduction through fine-grain non-transparent thread migration, referred to as mobile multithreading, in the proposed scalable NUMA sharedmemory architecture. The performance evaluation results for the conjugate gradient NAS benchmark demonstrate that the proposed fine-grain thread migration combined with data prefetching can be effectively used to reduce memory latency and switch traffic in NUMA sharedmemory multiprocessors with a large non-uniformity memory access ratio.
Migrating from novell to active directory (2013)

Ferris State University recognizes the importance of secure network file sharing resources to the internetworking of a university, as well as the need to reduce the number of accounts and passwords for end users to remember. Because of this and the need to reduce ongoing costs a decision was made in Fall 2010 to move from Novell to Active Directory for directory services and secure network file storage management.
A Model System for Study of Sex Chromosome Effects on Sexually Dimorphic Neural and Behavioral Traits (2002)

We tested the hypothesis that genes encoded on the sex chromosomes play a direct role in sexual differentiation of brain and behavior. We used mice in which the testis-determining gene (<i>Sry</i>) was moved from the Y chromosome to an autosome (by deletion of<i>Sry</i> from the Y and subsequent insertion of an<i>Sry</i> transgene onto an autosome), so that the determination of testis development occurred independently of the complement of X or Y chromosomes. We compared XX and XY mice with ovaries (females) and XX and XY mice with testes (males). These comparisons allowed us to assess the effect of sex chromosome complement (XX vs XY) independent of gonadal status (testes vs ovaries) on sexually dimorphic neural and behavioral phenotypes. The phenotypes included measures of male copulatory behavior, social exploration behavior, and sexually dimorphic neuroanatomical structures in the septum, hypothalamus, and lumbar spinal cord. Most of the sexually dimorphic phenotypes correlated with the presence of ovaries or testes and therefore reflect the hormonal output of the gonads. We found, however, that both male and female mice with XY sex chromosomes were more masculine than XX mice in the density of vasopressin-immunoreactive fibers in the lateral septum. Moreover, two male groups differing only in the form of their <i>Sry</i> gene showed differences in behavior. The results show that sex chromosome genes contribute directly to the development of a sex difference in the brain.
Tubular Polymersomes: A Cross-Linker-Induced Shape Transformation (2013)

Polymersomes, polymeric vesicles constructed of block copolymers, can undergo a sphere-to-tubule transition under the influence of a chemical modification of the polymeric bilayer. A strain-promoted alkyne-azide cycloaddition (SPAAC) reaction between azide handles inside the hydrophobic domain of the membrane and an excess of a bicyclo[6.1.0]nonyne (BCN)-cross-linker causes the vesicle to stretch in one dimension. Tubular polymersomes up to 2 μm in length can be obtained with this shape transformation. The introduction of a cleavable cross-linker makes this process reversible and opens the way for future drug delivery applications.
Minimizing chip-level simultaneous switching noise for high-performance microprocessor design (1996)

This paper describes the on-chip power bus modeling and switching noise analysis for high performance circuit design, and the methodology to minimize simultaneous switching noise by optimizing the placement of on-chip decoupling capacitors. The switching noise is analyzed at both the package level and the chip level. An equivalent circuit which consists of time-varying resistors, loading capacitors, and decoupling capacitors, is used to simulate the switching activities of functional blocks. Both the resistive and inductive voltage drops on the power bus are modelled to identify the hot spots on the chip and /spl Delta/V across the chip. Based on the noise analysis results, we can determine the amount of decoupling capacitance needed to keep the power supply voltage within specification, and optimize the final size and location of on-chip decoupling capacitors.
Macroscopic and nanometer scale stress measurement of Ni(Pt)Si silicide: Impact of thermal treatments ranging from millisecond to several hours (2013)

The authors have measured and compared the stress in nickel silicide full sheet layers prepared with added platinum on (001) p-type Si wafers by using either a rapid thermal anneal (RTA) at 390 °C or a millisecond submelt laser dynamic scanning anneal (DSA) at 800 °C. The room temperature tensile stress of the silicide annealed with DSA is 1.65 GPa, whereas that of the silicide annealed with RTA at 390 °C is 800 MPa. Our analysis confirms that the origin of the stress lies in thermal expansion factors. Despite some small variations, the stress remains highly tensile in both layers after a 1 h post-treatment at 400 °C, with values of 1.4 GPa and 850 MPa for the DSA and RTA samples, respectively. The authors also performed strain measurements with dark field electron holography in the source drain region of 28 nm field complementary metal oxide semiconductor field effect transistors, under the silicide dot. They then determined the stress inside the silicide by combining the strain measurement with finite element mechanical simulations; values of 1.5 GPa and 600 MPa were found at the nanometer scale for the DSA and RTA samples, respectively, which are consistent with the macroscopic observations.
Argentina: La obligación de conservación de datos en el correo electrónico por parte de los PSI (2004)

No puedo comenzar este trabajo sin recordar que los Proveedores de Servicio de Internet ? ISP (Internet Service Providers) son quienes posibilitan tanto la conexion entre los usuarios de Internet y los contenidos incorporados a los sitios de la red, como el uso del correo electronico u otras formas de transferencias electronicas de datos.
TEMPO-based Redox-sensitive Fluorescent Probes and Their Applications to Evaluating Intracellular Redox Status in Living Cells (2009)

Abstract Two redox-sensitive fluorescent probes were developed for evaluating the intracellular redox status of living cells as a complement to the widely used dye 2′,7′-dichlorodihydrofluorescein (DCFH).
Clinical applications of mifepristone (RU 486) and other antiprogestins: assessing the science and recommending a research agenda. (1993)

This publication is the product of an international expert committee convened conduct an evaluation and to develop recommendations concerning future research on the potential clinical use of antiprogestins in the United States. meeting was held in Washington D.C. April 13-14 1993. The committees report...reviews the data that served as the bases for approval of mifepristone in other countries. report includes 20 recommendations about various scientific issues that are important to the evaluation of mifepristone and other antiprogestins. report also includes the texts of the 12 background papers prepared for the meeting. (EXCERPT)
Propagation delay in RLC interconnection networks (2002)

The definition of Elmore's delay is extended to include inductance effects. The pulse delay of nonmonotonic rising node voltage in a tree-structured interconnection can be described by this new definition. The double moment matching method is presented. Based upon this approach, a closed-form formula for computing the second order moment of any tree-structured interconnection is established. The approach enables the derivation of computationally simple and closed-form formulas of signal propagation delays of nonmonotonic rising node voltages in tree-structured interconnections. The authors' results provide a new method for computing interconnection delay and reveal a critical link between net responses and net electrical properties. This formula set provides a tool to solve problems in the study of performance-driven-layout algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Stereoselective Synthesis of α-<i>C</i>-Substituted 1,4-Dideoxy-1,4-imino-<scp>d</scp>-galactitols. Toward Original UDP-Gal<i>f</i> Mimics via Cross-Metathesis (2006)

[reaction: see text] Various alpha-C-substituted 1,4-dideoxy-1,4-imino-d-galactitols were prepared efficiently from 1-O-acetyl-2,3,5,6-tetra-O-benzyl-d-glucofuranose by a four-step sequence involving as the key step the highly syn-selective TMSOTf-catalyzed addition of silylated nucleophiles to a glycofuranosylamine. Cross-metathesis of the alpha-C-allylated iminogalactofuranose derivative with an original uridin-5'-yl vinylphosphonate led to novel UDP-galactofuranose mimics. Such compounds are of interest as potential inhibitors of the mycobacterial galactan biosynthesis pathway.
Old Portuguese Vocalic Finals Phonology and Orthography of Accented -OU, -EU, -IU and -AO, -EO, -IO (1950)

Erma Learned, Old Portuguese Vocalic Finals Phonology and Orthography of Accented -OU, -EU, -IU and -AO, -EO, -IO, Language, Vol. 26, No. 2, Language Dissertation No. 44: Old Portuguese Vocalic Finals Phonology and Orthography of Accented -OU, -EU, -IU and -AO, -EO, -IO (Apr. - Jun., 1950), pp. 5-28