gebhart/patrepeval huggingface dataset:
A new transthyretin variant (His 69) associated with vitreous amyloid in an FAP family (1994)

Direct sequencing of the TTR gene from a patient with vitreous amyloid deposits revealed heterozygosity for a previously unreported variant transthyretin gene. Both the normal T and mutant C were present at the first position of codon 69, resulting in a substitution of histidine for tyrosine at amino acid 69 of the TTR protein. This mutation can be detected by conventional RFLP analysis, since a novel Dra III restriction site is created by the mutant base. In addition, a variation of the polymerase chain reaction was used to create an alternative method of detection. The patient presented with vitreous opacities and without polyneuropathy or cardiomyopathy which are normally seen in FAP. Mutant transthyretin may be responsible for the formation of vitreous deposits in other instances where there are minimal systemic findings and no family history of disease.
Application of NaYF4:Er3+ up-converting phosphors for enhanced near-infrared silicon solar cell response (2004)

Erbium-doped sodium yttrium fluoride (NaYF4:Er3+) up-conversion phosphors were attached to the rear of a bifacial silicon solar cell to enhance its reponsivity in the near-infrared. The incident wavelength and light intensity were varied and the resulting short circuit current of the solar cell was measured. A close match between the spectral features of the external quantum efficiency and the phosphor absorption is consistent with the energy transfer up-conversion process. The peak external quantum efficiency of the silicon solar cell was measured to be (2.5±0.2)% under 5.1 mW laser excitation at 1523 nm, corresponding to an internal quantum efficiency of 3.8%.
Vitamin intake: A possible determinant of plasma homocyst(e)ine among middle-aged adults (1997)

In almost all analyses, cases and controls showed similar associations between dietary variables and plasma homocyst(e)ine. Plasma homocyst(e)ine among users of vitamin supplement products was 1.5 mumol/L lower than that among nonusers. Further studies to examine possible causal relationships among vitamin intake, plasma homocyst(e)ine, and cardiovascular disease are needed.
Local Application of Optic Flow to Analyse Rigid versus Non-Rigid Motion (1999)

Optic flow has been a research topic of interest for many years. It has, until recently, been largely inapplicable to real-time video applications due to its computationally expensive nature. This paper presents a new, reliable flow technique called dynamic region matching, based on the work of Anandan[1], Lucas and Kanade[10] and Okutomi and Kanade[11], which can be combined with a motion detection algorithm (from stationary or stabilised camera image streams) to allow flow-based analyses of moving entities in real-time. If flow vectors need only be calculated for &quot;moving&quot; pixels, then the computation time is greatly reduced, making it applicable to real-time implementation on modest computational platforms (such as standard Pentium II based PCs). Applying this flow technique to moving entities provides some straightforward primitives for analysing the motion of those objects. Specifically, in this paper, methods are presented for: analysing rigidity and cyclic motion using residual ...
Dicyanogold (I) is a common human metabolite of different gold drugs. (1993)

Gold based drugs and their metabolites have been characterized using reversed phase, ion pairing chromatography with an inductively coupled plasma mass spectrometer as an element specific detector. For a patient receiving gold sodium thiomalate the principal gold species in the urine is [Au(CN)2]-, which is also seen in a low molecular weight infiltrate of the blood. The same compound is also identified in the urine and blood of a patient taking auranofin and in patients taking solganol. This represents the first identification of a specific gold metabolite in biological fluids taken from patients undergoing gold therapy and the first evidence that different gold drugs have common metabolites.
Borane‐Catalyzed Reductive α‐Silylation of Conjugated Esters and Amides Leaving Carbonyl Groups Intact (2015)

Described herein is the development of the B(C6F5)3-catalyzed hydrosilylation of α,β-unsaturated esters and amides to afford synthetically valuable α-silyl carbonyl products. The α-silylation occurs chemoselectively, thus leaving the labile carbonyl groups intact. The reaction features a broad scope of both acyclic and cyclic substrates, and the synthetic utility of the obtained α-silyl carbonyl products is also demonstrated. Mechanistic studies revealed two operative steps: fast 1,4-hydrosilylation of conjugated carbonyls and then slow silyl group migration of a silyl ether intermediate.
A Comparative QSAR Analysis of Quinazoline Analogues as Tyrosine Kinase (erbB-2) Inhibitors (2011)

In this paper, an attempt was made to develop a Quantitative Structure Activity Relationship (QSAR) model on a series of quinazoline derivatives acting as Protein tyrosine kinases (erbB-2) inhibitors using Multiple Linear Regression, Principal Component Regression and Partial Least Squares Regression methods. Among these three methods, Multiple Linear Regression (MLR) method has come out with a very promising result as compared to other two methods. Various 2D descriptors were calculated and used in the present analysis. For model validation, the dataset was divided into training and test sets using spherical exclusion method. The developed MLR- QSAR model was found to be statistically significant with respect to training (r2 =0.956), cross-validation (q2 = 0.915), and external validation (pred_r2= 0.6170). The developed MLR model suggests that Estate Contribution descriptors SaaOE-Index (30.07%) and SsCIE-index (15.79%) are the most important descriptors in predicting Tyrosine kinase (erbB-2) inhibitory activity. Electron withdrawing group at 4th position of quinazoline enhances the activity as evident by positive value of SsClE-index (15.79). In addition, for quinazoline substituents, estate contribution descriptors SsCH3E -index has a large deactivating effect.
Computational model of carbachol‐induced delta, theta, and gamma oscillations in the hippocampus (2001)

Field potential recordings from the rat hippocampus in vivo contain distinct frequency bands of activity, including delta (0.5-2 Hz), theta (4-12 Hz), and gamma (30-80 Hz), that are correlated with the behavioral state of the animal. The cholinergic agonist carbachol (CCH) induces oscillations in the delta (CCH-delta), theta (CCH-theta), and gamma (CCH-gamma) frequency ranges in the hippocampal slice preparation, eliciting asynchronous CCH-theta, synchronous CCH-delta, and synchronous CCH-theta with increasing CCH concentration (Fellous and Seinowski, Hippocampus 2000;1 0:187-197). In a network model of area CA3, the time scale for CCH-delta corresponded to the decay constant of the gating variable of the calcium-dependent potassium (K-AHP) current, that of CCH-theta to an intrinsic subthreshold membrane potential oscillation of the pyramidal cells, and that of CCH-gamma to the decay constant of GABAergic inhibitory synaptic potentials onto the pyramidal cells. In model simulations, the known physiological effects of carbachol on the muscarinic and K-AHP currents, and on the strengths of excitatory postsynaptic potentials, reproduced transitions from asynchronous CCH-theta to CCH-delta and from CCH-delta to synchronous CCH-theta. The simulations also exhibited the interspersed CCH-gamma/CCH-delta and CCH-gamma/CCH-theta that were observed in experiments. The model, in addition, predicted an oscillatory state with all three frequency bands present, which has not yet been observed experimentally.
Pathological Sprouting of Adult Nociceptors in Chronic Prostate Cancer-Induced Bone Pain (2010)

Pain frequently accompanies cancer. What remains unclear is why this pain frequently becomes more severe and difficult to control with disease progression. Here we test the hypothesis that with disease progression, sensory nerve fibers that innervate the tumor-bearing tissue undergo a pathological sprouting and reorganization, which in other nonmalignant pathologies has been shown to generate and maintain chronic pain. Injection of canine prostate cancer cells into mouse bone induces a remarkable sprouting of calcitonin gene-related peptide (CGRP(+)) and neurofilament 200 kDa (NF200(+)) sensory nerve fibers. Nearly all sensory nerve fibers that undergo sprouting also coexpress tropomyosin receptor kinase A (TrkA(+)). This ectopic sprouting occurs in sensory nerve fibers that are in close proximity to colonies of prostate cancer cells, tumor-associated stromal cells and newly formed woven bone, which together form sclerotic lesions that closely mirror the osteoblastic bone lesions induced by metastatic prostate tumors in humans. Preventive treatment with an antibody that sequesters nerve growth factor (NGF), administered when the pain and bone remodeling were first observed, blocks this ectopic sprouting and attenuates cancer pain. Interestingly, reverse transcription PCR analysis indicated that the prostate cancer cells themselves do not express detectable levels of mRNA coding for NGF. This suggests that the tumor-associated stromal cells express and release NGF, which drives the pathological reorganization of nearby TrkA(+) sensory nerve fibers. Therapies that prevent this reorganization of sensory nerve fibers may provide insight into the evolving mechanisms that drive cancer pain and lead to more effective control of this chronic pain state.
Engineering a pharmacologically superior form of leptin for the treatment of obesity (2005)

Leptin plays a central role in the homeostasis of body weight through its regulatory effects on appetite and energy expenditure, yet in trials as a therapeutic agent for the treatment of obesity in humans it has been disappointing. The poor clinical efficacy of leptin results from its short circulating half-life, low potency and poor solubility, necessitating large and frequent doses to obtain even modest clinical benefit. Engineered Fc-leptin immunofusins, consisting of the Fc fragment of an immunoglobulin gamma chain followed by leptin, exhibit improved pharmacological properties with very consistent and potent biological activities. Furthermore, in extending the circulating half-life of the protein in vivo from a few minutes for leptin to many hours for Fc-leptin, these proteins have the potential to reduce drastically the dosage and frequency of administration required to obtain clinical benefit. The results of this study show that the engineered leptin immunofusins described here have significantly enhanced pharmacological properties in comparison with the recombinant leptin that was used in clinical trials. As such, they could represent an important step towards a therapeutically superior form of leptin if the disappointing performance of leptin in early clinical trials was due to its poor pharmacological properties rather than any conceptual weakness in the strategy of using leptin for the treatment of obesity and its related disorders.
Delayed Hypersensitivity Reactions Provoked by Ribosomes from Acid-Fast Bacilli I. Ribosomal Isolation, Characterization, Delayed Hypersensitivity, and Specificity (1972)

Ribosomes and ribosomal subunits of Mycobacterium bovis (strain BCG) and M. smegmatis have been isolated and employed as skin test antigens in guinea pigs sensitized with homologous or heterologous organisms. Ribosomes and ribosomal subunits were found to be potent antigens for skin test purposes, and the 30S subunits were found to be more specific and active than the 50S subunits.
Polyol metabolism by Rhizobium trifolii (1980)

In Rhizobium trifolii 7000, the polyols myo-inositol, xylitol, ribitol, D-arabitol, D-mannitol, D-sorbital, and dulcitol are metabolized by inducible nicotinamide adenine dinucleotide-dependent polyol dehydrogenases. Five different polyol dehydrogenases were recognized: inositol dehydrogenase, specific for inositil; ribitol dehydrogenase, specific for ribitol; D-arabitol dehydrogenase, which oxidized D-arabitol, D-mannitol, and D-sorbitol; xylitol dehydrogenase, which oxidized xylitol and D-sorbitol; and dulcitol dehydrogenase, which oxidized dulcitol, ribitol, xylitol, and sorbitol. Apart from inositil and xylitol, all of the polyols induced more than one polyol dehydrogenase and polyol transport system, but the heterologous polyol dehydrogenases and polyol transport systems were not coordinately induced by a particular polyol. With the exception of xylitol, all of the polyols tested served as growth substrates. A mutant of trifolii 7000, which was constitutive for dulcitol dehydrogenase, could also grow on xylitol.
Localized scrambling of carbonyl ligands in compounds with metal-to-metal bonds (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLocalized scrambling of carbonyl ligands in compounds with metal-to-metal bondsF. Albert. Cotton, Douglas L. Hunter, and Pascual. LahuertaCite this: Inorg. Chem. 1975, 14, 3, 511–514Publication Date (Print):March 1, 1975Publication History Published online1 May 2002Published inissue 1 March 1975https://pubs.acs.org/doi/10.1021/ic50145a012https://doi.org/10.1021/ic50145a012research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Association of Antibody Reactivity to ELDKWA, a Glycoprotein 41 Neutralization Epitope, with Disease Progression in Children Perinatally Infected with HIV Type 1 (1998)

The association between antibody reactivity to the neutralizing epitope ELDKWA in the transmembrane glycoprotein gp41 and disease progression was investigated in 29 children perinatally infected with HIV-1. Levels of antibody reactivity to this epitope, measured over time, were associated with absolute CD4+ lymphocyte numbers and disease status, and inversely associated with the levels of acid-dissociated p24 antigen in the plasma. Early virus isolates from 10 of 12 children with no detectable antibody reactivity to this epitope were sequenced. Only three contained sequences that differed from the consensus, indicating that this epitope is well conserved in this population. None of these three children developed antibodies to the autologous sequences, indicating that at least 80% of children with negative antibody reactivity to this epitope were true nonresponders. Together, these results indicate that the ELDKWA determinant could be an important component in the formulation of a vaccine or for immunotherapeutic approaches to HIV-1 infection.
Isolation and Characterization of Stable Iron(I) Sulfide Complexes (2012)

The first examples of iron(I) sulfide complexes are presented, in contrast with the +2 and +3 oxidation states that are well-known in synthetic and biological systems. Spectroscopic and computational studies show a high-spin d7 configuration at the metal. Alkali metal cations play a key role in supporting the unusually low oxidation state.
Designing fully continuous phase screens for tailoring focal-plane irradiance profiles (1996)

An iterative algorithm for constructing fully continuous phase screens for tailoring far-field intensity profiles is presented. The algorithm is robust, stable, and, if run properly, maintains the continuous nature of the phase throughout the iterative process. The iterative procedure is applied to generate continuous phase screens to produce a 12th-power super-Gaussian far-field intensity profile.
Signal Amplification by Glyco‐qPCR for Ultrasensitive Detection of Carbohydrates: Applications in Glycobiology (2012)

Tiny amounts of carbohydrates (ca. 1 zmol) can be detected quantitatively by a real-time method based on the conjugation of carbohydrates with DNA markers (see picture). The proposed method (glyco-qPCR) provides uniform, ultrasensitive detection of carbohydrates, which can be applied to glycobiology, as well as carbohydrate-based drug discovery.
Fortification of food and beverages with phytonutrients. (2012)

With the emergence of fortified foods there is a worldwide increase in health awareness and interest in herbal alternatives. The change in outlook of consumers has encouraged the food and beverage industry to adopt fortification techniques to enhance the appeal of their products. Beverages and common foods like soups, yogurt, sauces, mayonnaise, jams, jellies, marmalades, cheese, margarine, bread and biscuits can be fortified with enriched herbal ext racts. This article reviews some of the trends in food fortification and its significance in the prevention of diseases.
Enhanced Gait-Related Improvements After Therapist- Versus Robotic-Assisted Locomotor Training in Subjects With Chronic Stroke (2008)

Therapist-assisted LT facilitates greater improvements in walking ability in ambulatory stroke survivors as compared to a similar dosage of robotic-assisted LT.
Cross standard system for future public safety and emergency communications (2005)

The public safety community shows an increased interest in standardized communication and information systems that can support reliable technology transparent multimedia communication during multinational emergency operations. It is very important today to introduce a public safety communication system that is able to use all available means of communications, including rapidly deployable networks, to cope with large scale disasters or/and to implement preventive measures. The article provides a survey of existing public safety communications systems, discusses their evolution, current status of research activities and presents the idea of a cross standard communication system (CSS). It provides an overview of the key research problems in CSS development.
Pharmacologically active benzo[b]thiophen derivatives. Part IV. 5- and 6-Alkyl derivatives with an N-alkyl-N-(2-chloroethyl)aminomethyl group in the 3-position (1968)

3-Chloromethylbenzo[b]thiophen reacted with N-ethyl-, N-isopropyl-, N-butyl-, N-t-butyl, or N-benzyl-ethanolamine to give the corresponding N-alkyl-N-(2-hydroxyethyl)-3-aminomethylbenzo[b]thiophen derivatives. With thionyl chloride in dry chloroform these amino-alcohols gave the corresponding N-alkyl-N-(2-chloroethyl)-3-aminomethylbenzo[b]thiophen hydrochlorides. A similar range of compounds was obtained from 5- or 6-methyl-benzo[b]thiophen but only the N-ethyl derivative was prepared from 5-ethyl-, 5-isopropyl-, or 5-t-butyl-benzo[b]thiophen. NN-Di-(2-hydroxyethyl)-3-aminomethylbenzo[b]thiophen and its 5-ethyl derivative were also prepared and converted into the corresponding nitrogen mustards. These compounds have been evaluated pharmacologically, with special emphasis on their anti-5HT and anti-tumour activity.
Excel 2007 Bible (2007)

This book is a single reference that's indispensable for Excel beginners, intermediate users, power users, and would-be power users everywhere Fully updated for the new release, this latest edition provides comprehensive, soup-to-nuts coverage, delivering over 900 pages of Excel tips, tricks, and techniques readers won't find anywhere else John Walkenbach, aka Mr. Spreadsheet, is one of the liworld's leading authorities on Excel Thoroughly updated to cover the revamped Excel interface, new file formats, enhanced interactivity with other Office applications, and upgraded collaboration features Includes a valuable CD-ROM with templates and worksheets from the book Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
The effect of spinning conditions on the mechanics of a spider's dragline silk (2001)

We studied the mechanical properties of dragline threads of the edible golden silk spider Nephila edulis that are produced under spinning speeds ranging from 0.1 to 400 mm s(-1) and temperatures ranging from 5 to 40 degrees C. These conditions affected the silk in all of the mechanical traits we tested (strain at breaking, breaking energy, initial Young's modulus and point of yielding). We argue that both trade-offs (between mechanical properties) and constraints (in the manufacturing process) have a large role in defining spider silk fibres.
Ferroelectric nanoparticles, wires and tubes: synthesis, characterisation and applications (2013)

Nanostructured materials are central to the evolution of future electronics and information technologies. Ferroelectrics have already been established as a dominant branch in the electronics sector because of their diverse application range such as ferroelectric memories, ferroelectric tunnel junctions, etc. The on-going dimensional downscaling of materials to allow packing of increased numbers of components onto integrated circuits provides the momentum for the evolution of nanostructured ferroelectric materials and devices. Nanoscaling of ferroelectric materials can result in a modification of their functionality, such as phase transition temperature or Curie temperature (TC), domain dynamics, dielectric constant, coercive field, spontaneous polarisation and piezoelectric response. Furthermore, nanoscaling can be used to form high density arrays of monodomain ferroelectric nanostructures, which is desirable for the miniaturisation of memory devices. This review article highlights some research breakthroughs in the fabrication, characterisation and applications of nanoscale ferroelectric materials over the last decade, with priority given to novel synthetic strategies.