gebhart/patrepeval huggingface dataset:
[Diagnostics and strategy of surgical treatment of multifocal atherosclerosis]. (2011)

The study included 148 patients with different combinations of multifocal atherosclerosis. The inclusion criteria were clinical manifestations of chronic cerebrovascular insufficiency concomitant with diseases of other arterial basins. The treatment strategies were chosen based on the results of examination by non-invasive methods for vascular visualization. Contrast agents were used only for curative purposes. The patients were divided into 2 groups depending on surgical strategy. Patients of group 1 underwent one-step reconstruction of several affected basins, those in group 2 step-by-step revascularization of different arterial basins with the use of X-ray endovascular interventions. The former approach was applied at the initial stage of the work. It creating a high risk of complications, the latter approach was preferred in the subsequent period. The incidence of complications in group 2 was 4.05% and the lethality rate 1.49%. These values were significantly higher in patients of group 1.
Review of Chinese Digital Terrestrial Television Broadcasting Standard, Key Technologies, and Performance (2007)

This paper provides a technical review of the Chinese Digital Terrestrial Television Broadcasting Standard (DTTB), which defines the physical layer transmission protocol, including the frame structure, channel coding, and modulation schemes. Key technologies adopted into this standard, such as time-domain synchronous orthogonal frequency division multiplexing (TDS-OFDM), etc., are discussed in detail. Measurement results from independent third parties show satisfactory receiving performance of high-definition and standard-definition TV signals under both indoor and outdoor environments for fixed and mobile reception. Major differences between this Chinese standard and the Digital Video Broadcasting-Terrestrial (DVB-T) standard, which has the largest deployment worldwide and also occupies an 8-MHz analog bandwidth, are also briefly addressed.
Recent Advances in the Design and Synthesis of SH2 Inhibitorsof Src, Grb2 and ZAP-70. (2000)

A perspective is offered on the recent development of Src-homology 2 (SH2) antagonists of Src, Grb2 and ZAP-70. Inhibiting Src SH2 is believed to be a potentially attractive way of regulating bone resorption. Grb2 SH2 has been shown to be an important component of the mitogenic ras pathway; and thus might be of utility in cancer research. ZAP-70 is a tyrosine kinase that is expressed solely in T-cells and natural killer cells. Since inhibition of the tandem SH2 domains of ZAP-70 has been shown to block T-cell proliferation, antagonists for this particular protein could have implications in immune suppression. The emphasis of the article is placed on the structure-based design, synthesis and biological activity of a number of newly reported SH2 antagonists in each of the three areas.
Nitric Oxide: Chemical Puzzles Posed by a Biological Messenger (1999)

Recent years have seen a massive growth of interest in the biological effects of nitric oxide (NO): It acts as a signaling molecule in blood vessels and the brain, and as a defense against pathogens in the immune system. Discussed are the chemical events underlying the physiology of this versatile little molecule.
A new mica-free turn insulation for rotating HV machines (2002)

A new mica-free turn insulation for rotating HV machines has been developed. The insulation consists of a high temperature resistant wire-enamel coated with a chromium oxide-binder layer. The chromium oxide acts as a PD resistant coating protecting the wire enamel from degradation. By accelerated aging tests it is shown that the chromium oxide coating is well as good as the normally used mica. The main advantages of the new insulation are the possibilities of a rapid production process and its space saving performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Midnight Raid (1966)

The following is a chapter from Fanshen: A Documentary of Revolution in a Chinese Village, which MR Press will publish in December. The setting for the incident described here, as for the entire book, is Long Bow Village in South Shansi. The author spent six months in Long Bow in 1948 as an observer attached to a work team whose task was to examine and help complete the land redistribution phase of the Chinese Revolution in this remote hamlet. MR readers will want to own this book, which is still available at the pre-publication price (see advertisement, page 29). —The EditorsThis article can also be found at the Monthly Review website, where most recent articles are published in full.Click here to purchase a PDF version of this article at the Monthly Review website.
Load Management using Heat-Pump Water Heater and Electric Vehicle Battery Charger in Distribution System with PV (2011)

This paper proposes a new load management method using Heat Pump Water Heater (HP-WH) and Electric Vehicle Battery Charger (EV-BC) in a distribution system with a high penetration of Photovoltaic generation system (PV). The proposed method implements a classification of the controllable loads (HP-WH, EV-BC) by distribution section and optimizes operation modes of the classified controllable loads. A distribution section enclosed with two or three IT switches, which are sectionalizing switches with sensors, is defined as a load management cluster, and a large number of controllable loads in a distribution feeder are classified into three clusters. All the customers with controllable loads determine beforehand two operation modes which achieve the satisfactory convenience and energy conservation; one is a nighttime consumption pattern and another is a daytime consumption pattern. Distribution System Operator (DSO) can collect the customers' information such as address codes and operation plans, and select either of the operation modes in each distribution section. The optimal combination of these operation modes is determined by Optimal Power Flow calculation (OPF). The objective is to improve load factor while keeping a power quality of a distribution system. The validity of the proposed method is verified through computer simulations using distribution network model.
Fluid-actuated variable focal length polymer microlens system (2005)

A polymer-based dynamic microlens system that can provide variable focal length and field-of-view (FOV) is fabricated and tested for its optical imaging characteristics. A flexible polydimethylsiloxane (PDMS) polymer membrane is used to form the lens surface. Two such membranes are combined with a spacer in between to form the fluidic lens chamber. The entire assembly is actuated by fluidic pressure using an external syringe pump to form either a double convex (DCX) or double concave (DCV) lens. The relationship between the focal length (<i>f</i>) and FOV of this dynamic lens as a function of the volume of the fluid pumped into or out of the lens chamber is investigated. The focal length of the single dynamic lens system can be tuned over the range of 75.9 to 3.1 mm and -75.9 to -3.3 mm, respectively, for the DCX and DCV lens configurations. The FOV that could be achieved using this dynamic lens system as DCX and DCV lenses is in the range of 0.12 to 61 degrees and 7 to 69 degrees, respectively. The smallest f-number (<i>f</i>/<sub>#</sub>) of 0.61, which corresponds to a numerical aperture of 0.64, could be achieved for a single dynamic lens system. An integrated two or three variable focal length DCV microlens system to provide wide FOV has also been fabricated and tested. The effective focal length of the integrated dynamic microlens system with two and three DCV lenses can be tuned in the range of -37.9 to -2.1 mm and -25.3 to -1.8 mm, respectively. The FOV achieved using the integrated two and three variable focal length DCV microlens systems were in the range of 8 to 76.7 degrees and 11.5 to 90.4 degrees, respectively.
Pipelining Scheduling and Hierarchical-Volume Management in a Storage Area Network (2006)

This paper implements two technologies in a storage area network (SAN): pipelining scheduling and hierarchical volume management. Firstly, we design a pipelining-scheduling, which overlaps network transfer procedure and disk I/O procedure. Concretely, two kinds of pipelining scheduling schemes have been implemented: (1) Fixed pipelining scheduling (FPS) synchronizing the pipeline stages at fixed time point; (2) Variable pipelining scheduling (VPS) synchronizing the pipeline stages dynamically according to the completion sequence of multiple procedures. Secondly, the hierarchical logical volume management (HLVM) provides a kind of storage virtualization on the different layers. By decomposing the original SCSI address, it builds a virtual layer between the physical storage devices and the applications.
High dynamic range image acquisition method for 3D solder paste measurement (2013)

In the solder paste inspection measurement system which is based on the structured light vision technology, the local oversaturation will emerge because of the reflection coefficient when the laser light project on PCB surface. As this, a high dynamic imaging acquisition system for the solder paste inspection research is researched to reduce the local oversaturation and misjudge. The Reflective liquid crystal on silicon has the merit that it can adjust the reflectance of the Incident light per-pixel. According to this merit, the high dynamic imaging acquisition system based on liquid crystal on silicon (LCoS) was built which using the high-resolution LCoS and CCD image sensor. The optical system was constructed by the imaging lens, the relay lens, the Polarizing Beam Splitter (PBS), and the hardware system was consist of ARM development board, video generic board, MCU and HX7809 according to the electrical characteristics of LCoS. Tests show that the system could reduce the phenomenon of image oversaturation and improve the quality of image.
A SUBMERGED HULL AND FOIL HYBRID SUPER-HIGH SPEED LINER (1991)

This paper introduces the super-high speed ship concept developed by the Techno-Super Liner Project in Japan. The load of the large ocean liner will be borne by its fully submerged hull and fully submerged foils. The Techno-Super Liner (TSL-F) has an extremely high seaworthiness, with almost no speed reduction in high seas. The hydrodynamic interference between the fully submerged hull and fully submerged foils is highlighted.
Probing the active site of glyoxalase I from human erythrocytes by use of the strong reversible inhibitor <i>S</i>-<i>p</i>-bromobenzylglutathione and metal substitutions (1981)

Glyoxalase I from human erythrocytes was studied by use of the strong reversible competitive inhibitor S-p-bromobenzylglutathione. Replacements of cobalt, manganese and magnesium for the essential zinc in the enzyme were made by a new procedure involving 10% methanol as a stabilizer of the enzyme. The K(m) value for the adduct of methylglyoxal and glutathione was essentially unchanged by the metal substitutions, whereas the inhibition constant for S-p-bromobenzylglutathione increased from 0.08mum for the Zn-containing enzyme to 1.3, 1.7 and 2.4mum for Co-, Mn- and Mg-glyoxalase I respectively. Binding of the inhibitor to the enzyme caused quenching of the tryptophan fluorescence of the protein, from which the binding parameters could be determined by the use of non-linear regression analysis. The highest dissociation constant was obtained for apoenzyme (6.9mum). The identity of the corresponding kinetic and binding parameters of the native enzyme and the Zn(2+)-re-activated apoenzyme and the clear differences from the parameters of the other metal-substituted enzyme forms give strong support to the previous identification of zinc as the natural metal cofactor of glyoxalase I. Binding to apoenzyme was also shown by the use of S-p-bromobenzylglutathione as a ligand in affinity chromatography and as a protector in chemical modification experiments. The tryptophan-modifying reagent 2-hydroxy-5-nitrobenzyl bromide caused up to 85% inactivation of the enzyme. After blocking of the thiol groups (about 8 per enzyme molecule) 6.1 2-hydroxy-5-nitrobenzyl groups were incorporated. Inclusion of S-p-bromobenzylglutathione with the modifying reagent preserved the catalytic activity of the enzyme completely and decreased the number of modified residues to 4.4 per enzyme molecule. The findings indicate the presence of one tryptophan residue in the active centre of each of the two subunits of the enzyme. Thiol groups appear not to be essential for catalytic activity. The presence of at least two categories of tryptophan residues in the protein was also shown by quenching of the fluorescence by KI.
Strategic Decision Making Multiobjective Decision Analysis with Spreadsheets (1998)

"Strategic Decision Making Multiobjective Decision Analysis with Spreadsheets." Journal of the Operational Research Society, 49(1), pp. 96–97
Purification and Properties of Human Erythrocyte Carbonic Anhydrases (1966)

Abstract Three different methods are described for separating hemoglobins from carbonic anhydrases in hemolysates from human erythrocytes. The preferred method involves adsorption on diethylaminoethyl Sephadex at pH 8.7 followed by selective elution of the carbonic anhydrases. Carbonic anhydrases A, B, and C are subsequently separated from each other on DEAE-Sephadex by elution with 0.05 m Trischloride buffer at pH 8.7. Complete amino acid analyses are reported for carbonic anhydrases B and C, with results in good accord with those of preparations obtained in other laboratories by different procedures. The partial specific volume of carbonic anhydrase B is found to be 0.731 ml per g and its intrinsic viscosity is 2.76 ml per g. Molecular weights from sedimentation, diffusion, and sedimentation equilibrium are close to 28,000 for both enzymes; estimates from the amino acid analyses are 28,730 for Enzyme B, and 30,000 for Enzyme C. The s020, w values are close to 2.75 S for both enzymes. The values for both s and D are lower than others previously reported, by a factor close to 1.2, but the resulting molecular weights are in good agreement with others. Studies of optical rotatory dispersion between 330 and 600 mµ are reported for the native and the acid-denatured carbonic anhydrases B and C, and also for solutions containing the substrate bicarbonate ion and, in other experiments, the inhibitor acetazolamide. The data in all these solvents give a good fit to the simple Drude equation, with λc values that lie below 210 mµ for native Enzyme B and average close to 210 mµ for Enzyme C. Analysis of the data in terms of the Moffitt-Yang and Shechter-Blout equations is also reported, but a computer analysis indicates that the basis for applying the former equation is dubious. There appears to be a small amount of helix (10 to 20%) in the acid-denatured proteins; the complexity of the optical rotatory dispersion spectra of the native proteins makes inferences concerning helix content uncertain (see following paper). Studies on the esterase activity of Enzyme B, with p-nitrophenyl acetate as substrate, are reported. Esterase activity rises with increasing pH between 7 and 9.5. Acetazolamide is a powerful inhibitor of the esterase activity, with Ki = 0.3 µm at pH 7, 0.9 µm at pH 8, and approximately 2.8 µm at pH 9. The inhibition appears to be noncompetitive.
Fabrication of multifilament Nb3Sn conductors (1976)

Multifilament conductors have been fabricated using niobium tubes with a sheathed tin-copper alloy inside and pure copper matrix outside. These composites have good workability, cold drawn without any intermediate heat treatment. Sample evaluation has included measurements of critical temperature, resistivity, and critical current density. The Nb3Sn formed by this method has much higher critical current density than the previous one with approximately the same tin concentration (12 at.%), but lies on the line extrapolated from the bronze method over the solid solubility limit.
The athlete's heart (2012)

<h3>ABSTRACT</h3> <h3>Background</h3> The early identification of deterioration in suspected COVID-19 patients managed at home enables a more timely clinical intervention, which is likely to translate into improved outcomes. We undertook an analysis of COVID-19 patients conveyed by ambulance to hospital to investigate how oxygen saturation and measurements of other vital signs correlate to patient outcomes, to ascertain if clinical deterioration can be predicted with simple community physiological monitoring. <h3>Methods</h3> A retrospective analysis of routinely collected clinical data relating to patients conveyed to hospital by ambulance was undertaken. We used descriptive statistics and predictive analytics to investigate how vital signs, measured at home by ambulance staff from the South Central Ambulance Service, correlate to patient outcomes. Information on patient comorbidities was obtained by linking the recorded vital sign measurements to the patient’s electronic health record at the Hampshire Hospitals NHS Foundation Trust. ROC analysis was performed using cross-validation to evaluate, in a retrospective fashion, the efficacy of different variables in predicting patient outcomes. <h3>Results</h3> We identified 1,080 adults with a COVID-19 diagnosis who were conveyed by ambulance to either Basingstoke & North Hampshire Hospital or the Royal Hampshire County Hospital (Winchester) between March 1<sup>st</sup> and July 31<sup>st</sup> and whose diagnosis was clinically confirmed at hospital discharge. Vital signs measured by ambulance staff at first point of contact in the community correlated with patient short-term mortality or ICU admission. Oxygen saturations were the most predictive of mortality or ICU admission (AUROC 0.772 (95 % CI: 0.712-0.833)), followed by the NEWS2 score (AUROC 0.715 (95 % CI: 0.670-0.760), patient age (AUROC 0.690 (95 % CI: 0.642-0.737)), and respiration rate (AUROC 0.662 (95 % CI: 0.599-0.729)). Combining age with the NEWS2 score (AUROC 0.771 (95 % CI: 0.718-0.824)) or the measured oxygen saturation (AUROC 0.820 (95 % CI: 0.785-0.854)) increased the predictive ability but did not reach significance. <h3>Conclusions</h3> Initial oxygen saturation measurements (on air) for confirmed COVID-19 patients conveyed by ambulance correlated with short-term (30-day) patient mortality or ICU admission, AUROC: 0.772 (95% CI: 0.712-0.833). We found that even small deflections in oxygen saturations of 1-2% below 96% confer an increased mortality risk in those with confirmed COVID at their initial community assessments.
A Heterodimeric Glucuronide Prodrug for Cancer Tritherapy: the Double Role of the Chemical Amplifier (2011)

Amplified action! We developed the therapeutic first targeting system that includes a chemical amplifier programmed both to release two potent anticancer drugs after a single enzymatic activation step and become cytotoxic itself once the amplification process is completed. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
[An experimental study on MR lymphography with various iron colloid agents]. (1992)

Magnetic resonance (MR) lymphography with iron colloid agents was evaluated in an animal model. The agents examined were ferric gluconate (FeG), saccharated ferric oxide (SFO), iron chondroitin sulfate (ICS) and cideferron (CiF), which were used as intravenous medication for iron deficiency anemia. The author performed time-dose-response and correlative histologic studies. MR images of the popliteal lymph nodes of rabbits were obtained at 1.5 T with a spin-echo sequence (TR = 300, TE = 30 msec) before and after subcutaneous injection of the agents to dorsal hind-feet. The images were evaluated by signal intensity (SI). Histologic specimens were evaluated for distribution and relative quantity of stained iron with a color image analyzer. The SI with FeG 4 mgFe increased by 50% at 5 to 60 minutes after injection but returned to the pre-contrast level 48 hours after. The SIs with SFO 8 mgFe, ICS 1 mgFe and CiF 1 mgFe decreased to the background level at 60 minutes and 48 hours after. The histologic study in combination with the images indicated that in case of FeG the particles in lymph increased SI while in the other agents those within macrophages decreased SI.
The nuclear pore complex protein ALADIN is mislocalized in triple A syndrome (2003)

Triple A syndrome is a human autosomal recessive disorder characterized by an unusual array of tissue-specific defects. Triple A syndrome arises from mutations in a WD-repeat protein of unknown function called ALADIN (also termed Adracalin or AAAS). We showed previously that ALADIN localizes to nuclear pore complexes (NPCs), large multiprotein assemblies that are the sole sites of nucleocytoplasmic transport. Here, we present evidence indicating that NPC targeting is essential for the function of ALADIN. Characterization of mutant ALADIN proteins from triple A patients revealed a striking effect of these mutations on NPC targeting. A variety of disease-associated missense, nonsense, and frameshift mutations failed to localize to NPCs and were found predominantly in the cytoplasm. Microscopic analysis of cells from a triple A patient revealed no morphological abnormalities of the nuclei, nuclear envelopes, or NPCs. Importantly, these findings indicate that defects in NPC function, rather than structure, give rise to triple A syndrome. We propose that ALADIN plays a cell type-specific role in regulating nucleocytoplasmic transport and that this function is essential for the proper maintenance andor development of certain tissues. Our findings provide a foundation for understanding the molecular basis of triple A syndrome and may lead to unique insights into the role of nucleocytoplasmic transport in adrenal function and neurodevelopment.
Structure Changes of Macrobenthic Community on Rocky Shores After the Hebei Spirit Oil Spill (2013)

In Korea, more than 300 oil spill accidents occur every year. Despite the frequency, only a small pool of data is available on the initial effect of oil spill on macrobenthic fauna inhabiting rocky shores. The aim of this study was to analyze the variation of macrobenthic fauna composition and community structure on rocky shores, and understand the impact of oil on rocky shore organisms after the Hebei Spirit oil spill. Field surveys were carried out in five regions dose to the wreck site in January, April and September 2008. Polluted sites after the Hebei Spirit oil spill showed that biological index consistently decreased for 9 months limited to breeding and recruitment of organisms by spilled oil. Macrobenthic community was subdivided into 3 groups by species elimination and differences between density of major dominant species: enriched biota community under a relatively stable environment, the second with relatively low ecological index and the last with poor community. In this study, species number did not clearly reflect the effect of oil on the rare and mobile species. However, mean density, biomass and community structure showed the effect of oil by considering breeding activity, decline in recruitment and variation pattern with time.
Murihiku Supergroup (Triassic—Jurassic) of Southland and South Otago (1966)

Abstract The name “Murihiku Supergroup” is proposed for those rocks, in general of older Mesozoic age, which overlie the Permian Bryneira, Productus Creek, Arthurton, and Kuriwao Groups in the Southland Syncline and underlie the erosion surface on which Cretaceous and Tertiary beds were deposited with major unconformity. North Etal and Taringatura Groups are introduced; North Range and Wairuna Peak Groups are given formal status. All are included in the Murihiku Supergroup.