gebhart/patrepeval huggingface dataset:
Diaryliodosyl salts (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiaryliodosyl saltsF. M. Beringer and P. BodlaenderCite this: J. Org. Chem. 1968, 33, 7, 2981–2984Publication Date (Print):July 1, 1968Publication History Published online1 May 2002Published inissue 1 July 1968https://pubs.acs.org/doi/10.1021/jo01271a089https://doi.org/10.1021/jo01271a089research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structural Basis of Cellulosome Efficiency Explored by Small Angle X-ray Scattering (2005)

Cellulose, the main structural component of plant cell walls, is the most abundant carbohydrate polymer in nature. To break down plant cell walls, anaerobic microorganisms have evolved a large extracellular enzyme complex termed cellulosome. This megadalton catalytic machinery organizes an enzymatic assembly, tenaciously bound to a scaffolding protein via specialized intermodular "cohesin-dockerin" interactions that serve to enhance synergistic activity among the different catalytic subunits. Here, we report the solution structure properties of cellulosome-like assemblies analyzed by small angle x-ray scattering and molecular dynamics. The atomic models, generated by our strategy for the free chimeric scaffoldin and for binary and ternary complexes, reveal the existence of various conformations due to intrinsic structural flexibility with no, or only coincidental, inter-cohesin interactions. These results provide primary evidence concerning the mechanisms by which these protein assemblies attain their remarkable synergy. The data suggest that the motional freedom of the scaffoldin allows precise positioning of the complexed enzymes according to the topography of the substrate, whereas short-scale motions permitted by residual flexibility of the enzyme linkers allow "fine-tuning" of individual catalytic domains.
Chemical Composition Analysis of Taraxacum Kok-saghyz Rodin Root (2015)

As the rubber industry development, the contradiction between supply and demand of domestic natural rubber latex will be more and more serious. In order to solve the problem, Taraxacum kok-saghyz Rodin(TKS) components were analyzed, and Taraxacum mongolicum Hand-Mazz(dandelion) roots were also analyzed for comparison. The composition analysis included contents of ash, acetone extract, holocellulose, α-cellulose and lignin(including acid soluble lignin and acid insoluble lignin), etc. The results showed that, ash content of TKS was higher than dandelion, holocellulose and lignin contents of TKS were lower than those of dandelion. XRD analysis showed that indices of cellulose crystallization in two samples were low. FTIR analysis showed that the TKS grass root sample had more characteristic absorption of amine while the dandelion sample did not.
Dipeptidyl peptidase-4: A key player in chronic liver disease (2013)

Dipeptidyl peptidase-4 (DPP-4) is a membrane-associated peptidase, also known as CD26. DPP-4 has widespread organ distribution throughout the body and exerts pleiotropic effects via its peptidase activity. A representative target peptide is glucagon-like peptide-1, and inactivation of glucagon-like peptide-1 results in the development of glucose intolerance/diabetes mellitus and hepatic steatosis. In addition to its peptidase activity, DPP-4 is known to be associated with immune stimulation, binding to and degradation of extracellular matrix, resistance to anti-cancer agents, and lipid accumulation. The liver expresses DPP-4 to a high degree, and recent accumulating data suggest that DPP-4 is involved in the development of various chronic liver diseases such as hepatitis C virus infection, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Furthermore, DPP-4 occurs in hepatic stem cells and plays a crucial role in hepatic regeneration. In this review, we described the tissue distribution and various biological effects of DPP-4. Then, we discussed the impact of DPP-4 in chronic liver disease and the possible therapeutic effects of a DPP-4 inhibitor.
Performance of a direct-conversion receiver with AC coupling (2000)

This paper analyzes the performance of a direct-conversion receiver (DCR) with AC coupling when the received signal is a BPSK. Although a DCR with AC coupling is extremely attractive from an implementation perspective, it Is employed most exclusively with "DC-free" modulation schemes such as binary frequency-shift keying (BFSK). More spectrally efficient modulation schemes, such as BPSK, are believed to suffer from significant performance loss because of the large signal bearing spectrum near dc. However, our analysis shows that by including an equalizer, the performance of a DCR with AC coupling when receiving BPSK signal is orders of magnitude better than previously reported. An equalizer is employed to mitigate the effects of intersymbol interference introduced by AC coupling. Compared to an ideal receiver, the SNR loss of a typical DCR with AC coupling and a linear equalizer is less than 2 dB for AC coupling corner frequencies as large as 30% of the symbol rate.
The Measurement and Improvement of the Transient A/F Characteristics of an Electronic Fuel Injection System (1982)

Mesure et amelioration des caracteristiques transitoires (melange air-carburant) d'un systeme d'injection electronique de carburant
Introduction: The problem of malaria and malaria control in pregnancy in sub-Saharan Africa (1996)

Plasmodium falciparum infection in pregnant women frequently leads to placental infection and low birth weight (< 2,500 grams) of the infant, particularly in the areas of high malaria transmission found in sub-Saharan Africa. Low birth weight is widely known to be an important risk factor for early infant mortality. To reduce the risk that maternal infection poses to child survival, many antenatal clinic programs recommend and provide antimalarial chemoprophylaxis, often with chloroquine (CQ) as a recommended element for antenatal care. Prior to the 1980s, despite widespread advocacy for this intervention, little was known about the effect of this intervention strategy. As an introduction to the Mangochi Malaria Research Project, which examined the efficacy of several antimalarial regimens using CQ or mefloquine in pregnant women in Malawi, we describe the background of knowledge regarding malaria infection in pregnant African women and the important elements of an intervention and prevention strategy.
Regulation of enzymes for erythrose 4-phosphate synthesis in Brevibacterium flavum. (1989)

Partially purified FBPase of B. flavum exhibited Michaelis-Menten kinetics, with Km of 22 μM for Fl, 6P2, but was inhibited by its substrate, Fl, 6P2, at more than 30μM. The inhibition reached 76% at 1.0mM. FBPase was also competitively inhibited by AMP, SI, 7P2, and S7P, the inhibitor constants being 32, 23, and 170μM, respectively. The presence of SI, 7P2 in B. flavum was suggested by the presence of ATP-dependent S7P kinase and SI, 7P2 aldolase activities, which corresponded to 27 and 89% of the 6PFK and Fl, 6P2 aldolase activities, respectively. Transaldolase activity involved in S7P formation was also detected in cell-free extracts. Partially purified PGI showed Kms of 1.4 and 0.54mM in the forward and reverse directions, respectively and was inhibited by E4P. The inhibition was of the mixed type with respect to G6P, with Ki and Ki' of 32 and 260 μM, respectively. None of the metabolites tested inhibited TK. Whereas the specific activities of PGI and 6PFK were not affected by carbon sources in the culture medium, those of FBPase, IPFK, and TK were elevated 2.6, 2.6, and 1.7-fold on growth on acetate, fructose, and citrate, respectively.
Origin of the heme Cotton effects in myoglobin and hemoglobin (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrigin of the heme Cotton effects in myoglobin and hemoglobinRobert W. Woody and Ming-Chu HsuCite this: J. Am. Chem. Soc. 1971, 93, 14, 3515–3525Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://pubs.acs.org/doi/10.1021/ja00743a036https://doi.org/10.1021/ja00743a036research-articleACS PublicationsRequest reuse permissionsArticle Views823Altmetric-Citations278LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Age-Related Macular Degeneration Staging by Color Fundus Photography vs. Multimodal Imaging—Epidemiological Implications (The Coimbra Eye Study—Report 6) (2020)

Epidemiology of age-related macular degeneration (AMD) is based on staging systems relying on color fundus photography (CFP). We aim to compare AMD staging using CFP to multimodal imaging with optical coherence tomography (OCT), infra-red (IR), and fundus autofluorescence (FAF), in a large cohort from the Epidemiologic AMD Coimbra Eye Study. All imaging exams from the participants of this population-based study were classified by a central reading center. CFP images were graded according to the International Classification and Grading System for AMD and staged with Rotterdam classification. Afterward, CFP images were reviewed with OCT, IR, and FAF and stage update was performed if necessary. Early and late AMD prevalence was compared in a total of 1616 included subjects. In CFP-based grading, the prevalence was 14.11% for early AMD (<i>n</i> = 228) and 1.05% (<i>n</i> = 17) for late AMD, nine cases (0.56%) had neovascular AMD (nAMD) and eight (0.50%) geographic atrophy (GA). Using multimodal grading, the prevalence increased to 14.60% for early AMD (<i>n</i> = 236) and 1.61% (<i>n</i> = 26) for late AMD, with 14 cases (0.87%) of nAMD and 12 (0.74%) of GA. AMD staging was more accurate with the multimodal approach and this was especially relevant for late AMD. We propose that multimodal imaging should be adopted in the future to better estimate and compare epidemiological data in different populations.
Maritime Situation Awareness Capabilities from Satellite and Terrestrial Sensor Systems (2013)

Maritime situation awareness is supported by a combination of satellite, airborne, and terrestrial sensor systems. This paper presents several solutions to process that sensor data into information that supports operator decisions. Examples are vessel detection algorithms based on multispectral image techniques in combination with background subtraction, feature extraction techniques that estimate the vessel length to support vessel classification, and data fusion techniques to combine image based information, detections from coastal radar, and reports from cooperative systems such as (satellite) AIS. Other processing solutions include persistent tracking techniques that go beyond kinematic tracking, and include environmental information from navigation charts, and if available, ELINT reports. And finally rule-based and statistical solutions for the behavioural analysis of anomalous vessels. With that, trends and future work will be presented.
All-fiber Q-switched single-frequency Tm-doped laser (2010)

We present an all-fiber Q-switched single-frequency laser oscillator operating in the eye-safe region at 1950nm, which is, to our best knowledge, the first demonstration of a Q-switched single-frequency fiber laser near 2μm.
Generation of Ca2+-independent sortase A mutants with enhanced activity for protein and cell surface labeling (2017)

Sortase A, a calcium-dependent transpeptidase derived from Staphylococcus aureus, is used in a broad range of applications, such as the conjugation of fluorescent dyes and other moieties to proteins or to the surface of eukaryotic cells. In vivo and cell-based applications of sortase have been somewhat limited by the large range of calcium concentrations, as well as by the often transient nature of protein-protein interactions in living systems. In order to use sortase A for cell labeling applications, we generated a new sortase A variant by combining multiple mutations to yield an enzyme that was both calcium-independent and highly active. This variant has enhanced activity for both N- and C-terminal labeling, as well as for cell surface modification under physiological conditions.
GEODSS: PAST AND FUTURE IMPROVEMENTS (2000)

The Ground-based Electro-Optical Deep Space Surveillance (GEODSS) system, a passive electro-optical visible wavelength sensor in the Space Surveillance Network (SSN), has been and continues to be upgraded. Introduction of the Optical Command, Control, and Communications Facility (OC 3 F) improved efficiency. The accuracy of its metric observation data of artificial deep space satellites, greatly improved just recently, will again be substantially improved. Improvements in sensitivity in both its metric and photometric (Space Object Identification, SOI) missions will also be achieved in the present acquisition phase.
Effect of Topical Local Anesthetic Application to Skin Harvest Sites for Pain Management in Burn Patients Undergoing Skin-Grafting Procedures (1999)

Topical lidocaine applied to skin-harvest sites produced an analgesic effect that reduced narcotic requirements compared with patients who received bupivacaine or placebo. Local anesthetic solutions aerosolized onto skin-harvest sites did not affect healing or produce toxic blood concentrations.
A signaling protocol for structured resource allocation (1999)

There is an emerging class of multi-party, multimedia, multi-flow applications that have a high-level structure that imposes dependencies between resource allocations for flows within the application. These applications are also capable of making intelligent decisions on how resource allocation should be controlled within the application. The development of such applications places new requirements on signaling protocols. This paper outlines these new requirements, discusses ways in which they can be supported and presents the design and implementation of an experimental signaling protocol that supports these requirements. This paper makes the case that for these structured applications, there is an advantage to allocating the resources in an integrated fashion, i.e. computation, storage and communication resources for all the flows are allocated at the same time in a coordinated fashion. The concept of a virtual mesh is introduced as a key abstraction that encapsulates the set of resources that are allocated and managed in an integrated fashion to meet the needs of applications. The paper presents two mesh setup algorithms and a performance evaluation comparing them. Temporal resource sharing within the virtual mesh is discussed in detail and signaling support for temporal sharing at setup and runtime is examined. It is important to characterize temporal sharing since it can significantly reduce the resource requirements for applications. We have implemented the Beagle signaling protocol that supports this integrated resource management model. Beagle representations and mechanisms for mesh setup and temporal sharing are described and a prototype implementation is presented.
Microcontact printing of laminin on oxygen plasma activated substrates for the alignment and growth of Schwann cells (2006)

Microenvironment mimicking biological situation is a vital issue in tissue regeneration. With much progress being made, one of the major challenges remains to develop a convenient method to fabricate the scaffold microenvironment suitable for cell attachment and proliferation. This article demonstrates the efficacy of microcontact printed laminin, an extracellular matrix protein, on three different oxygen plasma treatment substrates-tissue culture polystyrene, poly(methyl methacrylate) films, and chitosan films-for alignment and growth of the Schwann cells in in vitro culturing. Replica molding of polydimethylsiloxane elastomeric stamps, fabricated from patterned SU-8 structure on silicon master, was used to print laminin on the three substrates. Pattern and growth of Schwann cells for low (10(3) cells/cm(2)) and increased cell density (2 x 10(4) cells/cm(2)) on the varied substrates with and without microcontact printed laminin were characterized. Results of in vitro cell culture of Schwann cells showed a high degree of cell orientation on the laminin-micropatterned substrates for both cell densities. However, different cell seeding densities will strongly impact the morphology and orientation of Schwann cells. Microcontact printing proves to be a convenient means to pattern cell-recognition molecules on scaffold for cell-guilded growth in tissue regeneration.
A Unified Relational Approach to Grid Information Services (2003)

This first white paper of the relational Grid information services task group outlines an approach to Grid information services (GIS) that is based on the relational data model. While conceived as operating stand-alone, the system proposed herein could also be viewed as a complementary system, or as a set of services that would complement and interoperate with systems built according to the standards emerging from the Grid Information Services working group and the Grid Performance working group.
A‐part gel—An efficient adhesion prevention barrier (2006)

Two different poly(vinyl alcohol)-based gels (A-Part Gel) were compared and evaluated as possible adhesion prophylaxis gels. The gels were implanted to act as a physical barrier-and thus to prevent adhesions-in a rabbit sidewall model. The absorption time of any adhesion barrier is a critical parameter, since the wounded tissue needs to be covered during the healing process. Crosslinking by freeze-thawing helped to prolong the absorption time of the gels. To better understand the in vivo absorption, the gels were investigated in various physical in vitro methods such as decay measurements and experiments performed in a Soxhlet extraction thimble. The in vivo applicability of the gels by surgeons was judged in squeezing force measurements. The ability to cover the wounded area securely was measured with simple spreading experiments. Both gels could be squeezed out of the syringes easily and showed a homogenous spreading behavior. Comparing the two gels, the results of the in vitro absorption experiments were contradictive. Further, in vivo tests with correlations to the proposed in vitro measurements will reveal the correct interpretation. Nevertheless, the results in a pilot rabbit sidewall model were excellent for both A-Part gels, but only one gel was chosen for extended studies, showing only 20% adhesions when compared with the control group showing 100% strong adhesion formations. These data will be evaluated in other studies, and the use of an A-Part PVA-CMC gel for adhesion prevention has to be supported in clinical studies.
The Tim8-Tim13 Complex of Neurospora crassa Functions in the Assembly of Proteins into Both Mitochondrial Membranes (2004)

The Tim8 and Tim13 proteins in yeast are known to exist in the mitochondrial intermembrane space and to form a hetero-oligomeric complex involved in the import of the mitochondrial inner membrane protein Tim23, the central component of the TIM23 translocase. Here, we have isolated tim8 and tim13 mutants in Neurospora crassa and have shown that mitochondria lacking the Tim8-Tim13 complex were deficient in the import of the outer membrane β-barrel proteins Tom40 and porin. Cross-linking studies showed that the Tom40 precursor contacts the Tim8-Tim13 complex. The complex is involved at an early point in the Tom40 assembly pathway because cross-links can only be detected during the initial stages of Tom40 import. In mitochondria lacking the Tim8-Tim13 complex, the Tom40 precursor appears in a previously characterized early intermediate of Tom40 assembly more slowly than in wild type mitochondria. Thus, our data suggest a model in which one of the first steps in Tom40 assembly may be interaction with the Tim8-Tim13 complex. As in yeast, the N. crassa Tim23 precursor was imported inefficiently into mitochondria lacking the Tim8-Tim13 complex when the membrane potential was reduced. Tim23 import intermediates could also be cross-linked to the complex, suggesting a dual role for the Tim8-Tim13 intermembrane space complex in the import of proteins found in both the outer and inner mitochondrial membranes.
A new method of making new crown ethers (1974)

Crown ethers can be synthesised by the acidcatalysed insertion of an olefin into oligomers of 1,3,6-trioxocan and related 1,3-dioxacycloalkanes containing at least 4 oxygen atoms, in a one-step process under mild conditions.
Multiresolution Imaging of Neural Currents from MEG Data Using an Explicit Piecewise Image Model (2006)

MEG source imaging is an underdetermined inverse problem that suffers from a large number of unknown source parameters in realistic source settings. While linear source estimators offer poor spatial resolution, most recent non-linear approaches still lead to untractable computational costs. We propose a new multiresolution approach using an explicit piecewise image model of the distribution of neural currents. At each spatial resolution, the ill-posedness of the iterative estimation procedure is reduced owing to a compact parametric current model for the mass neural activity of spatially-extended brain regions. This procedure can be considered as either an imaging approach per se, or a source-selection pre-processing step to more computationally-demanding estimators