gebhart/patrepeval huggingface dataset:
.gamma.-Ray spectrometry for determination of radium-228 and radium-226 in natural waters (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.gamma.-Ray spectrometry for determination of radium-228 and radium-226 in natural watersJacqueline. Michel, Willard S. Moore, and Philip T. KingCite this: Anal. Chem. 1981, 53, 12, 1885–1889Publication Date (Print):October 1, 1981Publication History Published online1 May 2002Published inissue 1 October 1981https://pubs.acs.org/doi/10.1021/ac00235a038https://doi.org/10.1021/ac00235a038research-articleACS PublicationsRequest reuse permissionsArticle Views464Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Charges récupérables, contrat de couple et mise à disposition d'une ligne téléphonique (2009)

International audience
Potent and Fully Noncompetitive Peptidomimetic Inhibitor of Multidrug Resistance P-Glycoprotein (2010)

N(α)-Boc-l-Asp(OBn)-l-Lys(Z)-OtBu (reversin 121, 1), an inhibitor of the P-gp ABC transporter, was used to conceive compounds inhibiting the drug efflux occurring through the Hoechst 33342 and daunorubicin transport sites of P-gp, respectively H and R sites. Replacement of the aspartyl residue by trans-4-hydroxy-l-proline (4(R)Hyp) gave compounds 11 and 15 characterized by half-maximal inhibitory concentrations (IC(50)) of 0.6 and 0.2 μM, which are 2- and 7-fold lower than that of the parent molecule. The difference in IC(50) between 11 and 15 rests on the carbonyl group of the peptidyl bond, reduced in 15. Those compounds are rather specific of P-gp, having no or limited activity on MRP1 and BCRP. 15 displayed no marked cytotoxicity up to 10-fold its IC(50). Importantly, 15 equally inhibited the Hoechst 33342 and daunorubicin effluxes through a typical noncompetitive inhibition mechanism, suggesting its binding to a site different from the H and R drug-transport sites.
Linear Precoding for Downlink MC-CDMA Systems (2007)

In this paper, as an alternative to post-detection techniques, we derive two iterative joint linear precoding and power allocation methods for downlink MC-CDMA systems with multiple transmit antennas at the base station. The first method optimally solves the so called assigned target SINRs problem, i.e. determines the precoding coefficients and the minimum sum-power allocation under a constraint on the SINR of each user. The second method instead solves the maximum sum-rate problem, i.e. maximizes the system throughput under a constraint on the overall transmit power. The main result of this paper is that the proposed joint precoding and power control solutions provide an advantage with respect to suboptimal solutions for a fully loaded system, i.e. when the number of users is equal to the spreading factor times the number of transmit antennas. For lower loads, performance of the various schemes becomes closer.
Fingerprint Liveness Detection Using CNN Features of Random Sample Patches (2016)

As a result of the growing use of commercial fingerprint authentication systems in mobile devices, detection of fingerprint spoofing has become increasingly important and widely used. This study proposes a fingerprint liveness- detection method based on convolutional neural network (CNN) features extracted from fingerprint patches. Firstly, fingerprints are segmented, and then data augmentation is performed to increase the size of training data. Secondly, on the augmented fingerprint, locations of patches are determined through normal distributions of segmented areas of the fingerprint image. Finally, a voting strategy is applied on all patches to make a decision of live or fake fingerprints. Experimental results show that the proposed method can be applied to fingerprint liveness detection with a 3.42% average classification error rate on a LivDet2009 Identix sensor dataset.
Antitumor T-cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40 (2012)

Targeted and immune-based therapies are thought to eradicate cancer cells by different mechanisms, and these approaches could possibly complement each other when used in combination. In this study, we report that the in vivo antitumor effects of the c-KIT inhibitor, dasatinib, on the c-KIT mutant P815 mastocytoma tumor were substantially dependent on T cell-mediated immunity. We found that dasatinib treatment significantly decreased levels of Tregs while specifically enhancing tumor antigen-specific T-cell responses. We sought to further enhance this therapy with the addition of anti-OX40 antibody, which is known to provide a potent costimulatory signal to T cells. The combination of dasatinib and anti-OX40 antibody resulted in substantially better therapeutic efficacy compared with either drug alone, and this was associated with enhanced accumulation of tumor antigen-specific T cells in the tumor microenvironment. Furthermore, the combination regimen inhibited the function of Tregs and also resulted in significantly up-regulated expression of the IFN-γ-induced chemokines CXCL9, 10, and 11 in the tumor microenvironment, which provides a feasible mechanism for the enhanced intratumoral CTL infiltration. These studies delineate a strategy by which targeted therapy and immunotherapy may be combined to achieve superior antitumor responses in cancer patients.
Human papillomavirus infections (2004)

In this issue of Cancer , Anhang et al. present a review of written and verbal media reports that concern human papillomavirus infection, cervical cancer screening, and sexually transmitted infection. Their findings suggest that it is little wonder that the public is informed so inadequately about the virus, the consequences of infection, and the natural history of cervical neoplasia. See also pages 308–14.
THE FEIST SYNTHESIS OF PYRROLE-3-CARBOXYLIC ESTERS (1965)

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Vacuolar H+-ATPase Activity Is Required for Endocytic and Secretory Trafficking in <i>Arabidopsis</i> (2006)

In eukaryotic cells, compartments of the highly dynamic endomembrane system are acidified to varying degrees by the activity of vacuolar H(+)-ATPases (V-ATPases). In the Arabidopsis thaliana genome, most V-ATPase subunits are encoded by small gene families, thus offering potential for a multitude of enzyme complexes with different kinetic properties and localizations. We have determined the subcellular localization of the three Arabidopsis isoforms of the membrane-integral V-ATPase subunit VHA-a. Colocalization experiments as well as immunogold labeling showed that VHA-a1 is preferentially found in the trans-Golgi network (TGN), the main sorting compartment of the secretory pathway. Uptake experiments with the endocytic tracer FM4-64 revealed rapid colocalization with VHA-a1, indicating that the TGN may act as an early endosomal compartment. Concanamycin A, a specific V-ATPase inhibitor, blocks the endocytic transport of FM4-64 to the tonoplast, causes the accumulation of FM4-64 together with newly synthesized plasma membrane proteins, and interferes with the formation of brefeldin A compartments. Furthermore, nascent cell plates are rapidly stained by FM4-64, indicating that endocytosed material is redirected into the secretory flow after reaching the TGN. Together, our results suggest the convergence of the early endocytic and secretory trafficking pathways in the TGN.
Influence of Compacted Hydrophobic and Hydrophilic Colloidal Silicon Dioxide on Tableting Properties of Pharmaceutical Excipients (2005)

The effect of noncompacted and compacted hydrophilic as well as hydrophobic colloidal silicon dioxide (CSD) on tableting properties of three different pharmaceutical excipients used for direct compression, namely, Avicel PH 101, Starch 1500, and Tablettose 80, was investigated. Binary powder mixtures containing 0.5% CSD and 99.5% excipient were compressed on an instrumented single-punch tablet press, and the radial tensile strength/compaction load profiles were examined. The Ryshkewitch-Duckworth relationship shows that the influence of CSD on tablet strength was dependent on the hydrophobic and hydrophilic nature of the CSD and on the compaction characteristics of the excipients. Tablets from each excipient with and without CSDs were subjected to different levels of relative humidity at 20 degrees C for 7 days. The sorption isotherms and the radial tensile strengths of the tablets after the storage period showed that neither hydrophilic nor hydrophobic CSD influenced the tablet properties of Avicel PH 101, Starch 1500, and Tablettose 80. Moreover, ternary powder mixtures containing magnesium stearate as a third component were compressed in order to study the influence of CSD on the deleterious effect of magnesium stearate on the interparticle bonding. The radial tensile strength/compaction load profiles and the residual and ejection forces of tablets made from ternary mixtures showed that CSD eliminated the negative effect of magnesium stearate on interparticle bonding while maintaining the lubrication action, in a manner that was affected by its hydrophobicity/hydrophilicity and by the particle deformation properties of the excipient upon compression.
Silicon photonics for next generation computing systems (2008)

Although InP-based photonic ICs (PICs) have been researched for many years, widespread acceptance of the viability of such technologies has not occurred until recently. A few relatively new commercial existence proofs have now proven that multiple functions can be successfully performed on a single InP chip with advantages in cost, size, performance, and power dissipation. As a result of these, as well as some market realities and an ever growing body of research existence proofs, the development of viable PIC products now seems to be a key goal of many component suppliers. This tutorial will review current integration approaches and results, with some slight emphasis on our UCSB work.
Redox Control on the Cell Surface: Implications for HIV-1 Entry (2003)

Proteins that work outside cells nearly always contain disulfide bonds. The prevailing view is that these bonds have been added during evolution to enhance protein stability. Recent evidence suggests that disulfide bonds can also control protein function. Certain secreted proteins contain one or more disulfide bonds that can control function by breaking and reforming in a controlled way. This review focuses on disulfide exchange events on the cell surface, with a particular reference to two proteins involved in HIV-1 infection. The primary HIV-1 receptor on immune cells, CD4, and the viral envelope glycoprotein, gp120, play a central role in HIV-1 entry. Redox change in a disulfide bond or bonds in one or both of these proteins appears to be important for HIV-1 entry.
Evaluation and development of water wave theories for engineering application (1974)

Comparison with Stream-function Theory Developed by Von SchwindtandiReideemecmcn-aewrn ery
Scientific rotoscoping: a morphology‐based method of 3‐D motion analysis and visualization (2010)

Three-dimensional skeletal movement is often impossible to accurately quantify from external markers. X-ray imaging more directly visualizes moving bones, but extracting 3-D kinematic data is notoriously difficult from a single perspective. Stereophotogrammetry is extremely powerful if bi-planar fluoroscopy is available, yet implantation of three radio-opaque markers in each segment of interest may be impractical. Herein we introduce scientific rotoscoping (SR), a new method of motion analysis that uses articulated bone models to simultaneously animate and quantify moving skeletons without markers. The three-step process is described using examples from our work on pigeon flight and alligator walking. First, the experimental scene is reconstructed in 3-D using commercial animation software so that frames of undistorted fluoroscopic and standard video can be viewed in their correct spatial context through calibrated virtual cameras. Second, polygonal models of relevant bones are created from CT or laser scans and rearticulated into a hierarchical marionette controlled by virtual joints. Third, the marionette is registered to video images by adjusting each of its degrees of freedom over a sequence of frames. SR outputs high-resolution 3-D kinematic data for multiple, unmarked bones and anatomically accurate animations that can be rendered from any perspective. Rather than generating moving stick figures abstracted from the coordinates of independent surface points, SR is a morphology-based method of motion analysis deeply rooted in osteological and arthrological data.
Evaluation of Genotype MTBDRsl Assay to Detect Drug Resistance Associated with Fluoroquinolones, Aminoglycosides and Ethambutol on Clinical Sediments (2012)

Genotype MTBDRsl is simple, rapid, economical assay that can be used to detect commonly known resistance associated with Fluoroquinolone, second line injectable drugs and ethambutol. The assay detects the targeted resistance in less time as compared to phenotypic DST. But due to low NPV to FQ (88%) and EMB (43.21%), the assay results must be interpreted in coordination with the phenotypic DST.
Substrate hole current and oxide breakdown (1986)

It is known that when an n-channel metal-oxide-semiconductor field-effect transistor is biased with a high positive gate voltage, a hole current appears in the substrate cathode. Recent experiments indicate that the holes are generated within the oxide. We show that this hole generation mechanism is linked to oxide time-dependent breakdown. When the hole fluence reaches a certain critical value, breakdown occurs. This is in agreement with a hole-trapping-induced breakdown model. For very thin oxides the hole generation rate can become so low that the substrate hole current is dominated by the tunneling of valence-band electrons which is not expected to contribute to oxide breakdown. A different mechanism of hole generation such as hot-hole tunneling from the anode may be responsible for oxide breakdown in the important case of low gate voltage (&lt;6 V).
Concurrent Load-Aware Adjustment of User Association and Antenna Tilts in Self-Organizing Radio Networks (2013)

Network operators expect a coordinated handling of parameter changes submitted to the operating network's configuration management entity by closed-loop self-organizing network (SON) techniques. For this reason, a major research goal for emerging SON technologies is to achieve coordinated results out of a plethora of independently or even concurrently running use-case implementations. In this paper, we extend current frameworks to compute desirable user associations by an interference model that explicitly takes base-station loads into account. With the aid of this model, we are able to make considerably more accurate estimations and predictions of cell loads compared with established methods. Based on the ability to predict cell loads, we derive algorithms that jointly adapt user-association policies and antenna-tilt settings for multiple cells. We demonstrate by detailed numerical evaluations of realistic networks that these algorithms can be applied to capacity and coverage optimization, mobility load balancing, and cell outage compensation use cases. As a result, rather than performing any heading or tailing coordination, the joint technique inherently comprises all three use cases, making their coordination redundant. For all scenarios studied, the joint optimization of tilts and user association improves quality of service in terms of the fifth percentile of user throughput compared with state-of-the-art techniques. The proposed models and techniques can be straightforwardly extended to other physical and soft parameters.
The Preparation of Cyclic Siliconmethylene Compounds (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Cyclic Siliconmethylene CompoundsWilliam A. KrinerCite this: J. Org. Chem. 1964, 29, 6, 1601–1606Publication Date (Print):June 1, 1964Publication History Published online1 May 2002Published inissue 1 June 1964https://doi.org/10.1021/jo01029a081RIGHTS & PERMISSIONSArticle Views328Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (631 KB) Get e-Alerts Get e-Alerts
A configurable event service for distributed systems (2002)

Event services are needed for control systems, implementing management of networks and distributed and event based applications. In all these applications it is necessary to filter out unwanted events and combine low-level event sequences into a higher level, more abstract event to trigger an action. In this paper we present a flexible and powerful distributed event service which can be used to process and disseminate events for many different applications. The service can be configured dynamically at two levels. Composite events can be defined as rules in terms of event sequences using the GEM notation. These rules can be loaded, removed, enabled and disabled dynamically within event monitoring interpreters. Interpreters and event disseminator components can then be dynamically configured onto physical nodes within the system using the Darwin configuration environment to distribute the monitoring close to where events are generated. This reduces network traffic caused by event generation in large systems.
Nutritional status of patients with acquired immunodeficiency syndrome. (1988)

Nutritional status may be an important factor in the prognosis of morbidity and mortality. We assessed the nutritional status of individuals seropositive for human immunodeficiency virus (HIV) (as confirmed by Western blot) and of patients with AIDS, by determining the concentration in serum of total protein, albumin, prealbumin (transthyretin), and retinol-binding protein. HIV-seropositive individuals showed no significant difference from normal volunteers in values for prealbumin, albumin, and retinol-binding protein. Patients with AIDS showed significantly smaller prealbumin and albumin concentrations than did normal and HIV-positive individuals. There was no significant difference in the concentration of retinol-binding protein among the three groups. The concentration of total serum protein was significantly greater in HIV-positive individuals and in patients with AIDS than in normal individuals. Thus, the nutritional status of patients with AIDS may be a factor for morbidity and mortality.
Design and implementation of an automated human activity monitoring application for wearable devices (2008)

We present the design and implementation of a system that monitors physical activities of a human user wearing a portable device equipped with inertial sensors. This system uses inertial sensor data to automatically classify human activities using a trained classifier. The portable device is used both as a sensing as well as an application platform with user interface. The software application includes the classifier and a programmable graphical user interface that displays feedback on physical fitness related metrics such as activity type, duration, and the amount of energy expended while performing the action. The application also enables users to review historical data and set future goals. Processed activity information is stored and transmitted using a wireless connection to a remote web-based server, which can publish this feedback to the users on a secure website as needed. This application aims at improving user's awareness and lifestyle by providing on-demand feedback using real-time, reflective and motivational modes. In short, we propose a system that integrates sensing, computing, and user interaction into a wearable platform with the purpose of monitoring and reporting users' physical performance metrics with the goal of motivating physical fitness or active lifestyle without interfering with their day-to-day activities.
Heme Binding Properties of <i>Staphylococcus aureus</i> IsdE (2007)

Staphylococcus aureus is the source of a large number of hospital-acquired infections, of which many are serious and can lead to death. Iron is critically important to the survival and growth of the bacterium, and complex, multistep mechanisms are present to fulfill the necessary iron requirement. Isd proteins located on the wall and membrane of S. aureus have been proposed to function in heme acquisition. We report characterization of the S. aureus heme-binding protein IsdE, the lipoprotein component of a membrane-localized ABC transporter that is believed key to receiving heme from cell wall-anchored Isd proteins. Magnetic circular dichroism (MCD) data, which greatly extend the results from our initial study of IsdE in bacterial cell lysates (Mack, J., Vermeiren, C., Heinrichs, D. E., and Stillman, M. J. (2004) Biochem. Biophys. Res. Commun. 320, 781-788), probe the ligand and redox properties of the bound heme. The MCD data show that IsdE, when overexpressed in E. coli, binds either ferric or ferrous heme but that the largest fraction is low spin ferrous heme. Studies of mutants allowed identification and characterization of the ligands in the fifth and sixth position on the heme iron as histidine, proximally, and methionine, distally. This histidine-methionine heme-iron ligation is unique to heme transport proteins. The smaller fraction of ferric heme in the protein is not bound by methionine, allowing for access by strong field ligands, such as cyanide. Electrospray ionization mass spectral data are reported for the first time and show that only one heme ligand binds per IsdE protein molecule. These data also show there is little change in the conformation of the protein between the heme-bound and heme-free species, indicating that the heme-free IsdE adopts a structure essentially independent of the heme. The mass spectral data clearly show that IsdE reversibly unwinds under denaturing conditions to form at least two distinct, heme-free conformations.