gebhart/patrepeval huggingface dataset:
OFRewind: enabling record and replay troubleshooting for networks (2011)

Debugging operational networks can be a daunting task, due to their size, distributed state, and the presence of black box components such as commercial routers and switches, which are poorly instrumentable and only coarsely configurable. The debugging tool set available to administrators is limited, and provides only aggregated statistics (SNMP), sampled data (NetFlow/sFlow), or local measurements on single hosts (tcpdump). In this paper, we leverage split forwarding architectures such as OpenFlow to add record and replay debugging capabilities to networks – a powerful, yet currently lacking approach. We present the design of OFRewind, which enables scalable, multi-granularity, temporally consistent recording and coordinated replay in a network, with finegrained, dynamic, centrally orchestrated control over both record and replay. Thus, OFRewind helps operators to reproduce software errors, identify data-path limitations, or locate configuration errors. 1
Intervertebral Disc Prostheses (2003)

Although still in the early phases of development, functional disc replacement will become a part of the spine surgeon's armamentarium for the treatment of patients with disc-related pain unresponsive to nonoperative care. The future in this area is exciting and bright with the introduction of new materials and new designs for implants. However, as with any new technology, there must be careful consideration of the safety of the devices, and their effectiveness will only be determined in long-term follow-up studies.
Ouabain-resistant mutants of the rat Na,K-ATPase alpha 2 isoform identified by using an episomal expression vector. (1990)

Site-directed mutagenesis was used to identify residues responsible for the greater than 1,000-fold difference in ouabain sensitivity between the rat Na,K-ATPase alpha 1 and alpha 2 isoforms. A series of mutagenized cDNAs was constructed that replaced residues of the rat alpha 2 subunit with the corresponding residues from the rat alpha 1 subunit. These cDNAs were cloned into a mammalian episomal expression vector (EBOpLPP) and expressed in ouabain-sensitive primate cells. Either of two single substitutions introduced into the rat alpha 2 subunit cDNA (Leu-111----Arg or Asn-122----Asp) conferred partial resistance (approximately 10 microM ouabain) upon transformed cells. This resistance was intermediate between the levels conferred by the rat alpha 1 cDNA (approximately 500 microM ouabain) and the rat alpha 2 cDNA (approximately 0.2 microM ouabain). A double substitution of the rat alpha 2 cDNA (Leu-111----Arg and Asn-122----Asp) conferred a resistance level equivalent to that obtained with rat alpha 1. These results demonstrate that the residues responsible for isoform-specific differences in ouabain sensitivity are located at the end of the H1-H2 extracellular domain. The combination of site-directed mutagenesis and episomal expression provides a useful system for the selection and analysis of mutants.
Synthesis of <i>s</i>‐triazolo[4,3‐<i>b</i>]pyridazine <i>C</i>‐nucleosides (1981)

Abstract A one step synthesis of s ‐triazolo[4,3‐ b ]pyridazine using 3‐chloro‐6‐hydrazinopyridazine and an appropriate thioformimidate is described. Applying this procedure to 5‐ O ‐benzoyl‐1‐benzylthio‐1‐formimidate‐D‐ribofuranose, 5′ benzoyl‐6‐chloro‐3β‐D‐ribofuranosyl‐s‐triazolo[4,3‐ b ]pyridazine was obtained. Substitutions of chlorine by nucleophilic reagents afforded some derivatives of a new series of C ‐nucleo‐sides. Structural determination including anomeric configuration assignment is discussed based mainly on 1 H nmr spectroscopy.
Proportionality: A Valid Alternative to Correlation for Relative Data (2015)

In the life sciences, many measurement methods yield only the relative abundances of different components in a sample. With such relative-or compositional-data, differential expression needs careful interpretation, and correlation-a statistical workhorse for analyzing pairwise relationships-is an inappropriate measure of association. Using yeast gene expression data we show how correlation can be misleading and present proportionality as a valid alternative for relative data. We show how the strength of proportionality between two variables can be meaningfully and interpretably described by a new statistic ϕ which can be used instead of correlation as the basis of familiar analyses and visualisation methods, including co-expression networks and clustered heatmaps. While the main aim of this study is to present proportionality as a means to analyse relative data, it also raises intriguing questions about the molecular mechanisms underlying the proportional regulation of a range of yeast genes.
Incidence and molecular analysis of <i>Vibrio cholerae</i> associated with cholera outbreak subsequent to the super cyclone in Orissa, India (2002)

An epidemiological study was carried out to find out the aetiological agent for diarrhoeal disorders in the cyclone and flood affected areas of Orissa, India. Rectal swabs collected from 107 hospitalized diarrhoea patients were bacteriologically analysed to isolate and identify the various enteropathogens. Detection of toxic genes among E. coli and V. cholerae was carried out by polymerase chain reaction (PCR) assay. Of the 107 rectal swabs analysed, 72.3% were positive for V. cholerae O1 Ogawa, 7.2% for V. cholerae O139, 1.2% for E. coli (EAggEC) and 1.2% for Shigella flexneri type 6. Using multiplex PCR assay it was found that all V. cholerae isolates were ctxA positive and El Tor biotype. Strains of V. cholerae O1 were observed to be resistant to nalidixic acid, furazolidone, streptomycin, co-trimoxazole and ampicillin. Except for nalidixic acid, the resistance pattern for O139 was identical to that of O1 strains. Representative strains of V. cholerae were further characterized by randomly amplified polymorphic DNA (RAPD) analysis and ribotyping. Both O1 and O139 V. cholerae strains exhibited the R3 pattern of ribotype and belonged to a similar pattern of RAPD compared with that of Calcutta strains. Early bacteriological and epidemiological investigations have revealed the dominance of V. cholerae O1 among the hospitalized patients in cyclone affected areas of Orissa. Drinking water scarcity and poor sanitation were thought to be responsible for these diarrhoeal outbreaks. Timely reporting and implementation of appropriate control measures could contain a vital epidemic in this area.
Healing Power Found in “Nano Knitting” (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy of Locally Delivered Polyclonal Immunoglobulin against <i>Pseudomonas aeruginosa</i> Peritonitis in a Murine Model (1999)

Infectious peritonitis results from bacterial contamination of the abdominal cavity. Conventional antibiotic treatment is complicated both by the emergence of antibiotic-resistant bacteria and by increased patient populations intrinsically at risk for nosocomial infections. To complement antibiotic therapies, the efficacy of direct, locally applied pooled human immunoglobulin G (IgG) was assessed in a murine model (strains CF-1, CD-1, and CFW) of peritonitis caused by intraperitoneal inoculations of 10(6) or 10(7) CFU of Pseudomonas aeruginosa (strains IFO-3455, M-2, and MSRI-7072). Various doses of IgG (0.005 to 10 mg/mouse) administered intraperitoneally simultaneously with local bacterial challenge significantly increased survival in a dose-dependent manner. Local intraperitoneal application of 10 mg of IgG increased animal survival independent of either the P. aeruginosa or the murine strains used. A local dose of 10 mg of IgG administered up to 6 h prophylactically or at the time of bacterial challenge resulted in 100% survival. Therapeutic 10-mg IgG treatment given up to 12 h postinfection also significantly increased survival. Human IgG administered to the mouse peritoneal cavity was rapidly detected systemically in serum. Additionally, administered IgG in peritoneal lavage fluid samples actively opsonized and decreased the bacterial burden via phagocytosis at 2 and 4 h post-bacterial challenge. Tissue microbial quantification studies showed that 1.0 mg of locally applied IgG significantly reduced the bacterial burden in the liver, peritoneal cavity, and blood and correlated with reduced levels of interleukin-6 in serum.
Age-associated decline of hepatic handling of cholephilic anions in humans is reverted by S-adenosylmethionine (SAMe) (1990)

Decreased fluidity of hepatocyte plasma membrane may contribute to the age-associated changes of liver function. This study aimed at investigating whether the hepatic clearance of organic anions declines with age and whether S-adenosylmethionine (SAMe), a substance proven to be effective in reversing the age-related decrease of membrane fluidity, might influence this process. Nicotinic acid (NA) half-life and serum bilirubin pharmacokinetics after NA load (5.9 mumol/kg body weight i.v.) were studied in 10 healthy young males (YM) aged 14-28 years and in 10 healthy elderly males (EM) aged 65-81 years, before and after SAMe administration (800 mg/day intravenously for 10 days). At baseline, EM showed serum total bilirubin (STB) levels significantly higher than YM. Similarly, the bilirubinaemic mean curves, STB peak and STB time curve concentration after NA load, expressed as area under the curve (AUC), were significantly higher in EM than in YM (p less than 0.01). NA half-life was also significantly prolonged in the aged group (p less than 0.001). SAMe treatment was followed by a significant decrease of basal STB, STB peak and AUC of STB after NA load in EM (p less than 0.01 vs pre-treatment values) while NA half-life was significantly shortened in both groups (p less than 0.001). As NA and bilirubin share a common carrier protein for hepatic uptake, bilitranslocase, the changes observed in EM may be attributed to the reduced lateral mobility of hepatocyte plasma membrane proteins occurring with age. SAMe, by improving membrane fluidity, may increase the diffusion coefficient of bilitranslocase restoring the hepatic handling of organic anions.
Perpendicular magnetic anisotropy in Pd/Co thin film layered structures (1985)

This letter presents the results of magnetic studies of thin film, periodic, Pd/Co layered structures with ultrathin cobalt (4–13 Å). We show that films with Co thicknesses less than 8 Å are easy to magnetize along a direction normal to the film surface. The best films have a saturation magnetization of about 500 emu/cm3 and a coercivity of 550 Oe, and thus they are candidates for a vertical magnetic recording medium. We attribute the perpendicular magnetic easy axis in these films to surface anisotropy at Pd/Co interfaces and strain in thin Co layers.
On muting mobile terminals for uplink interference mitigation in HetNets—system-level analysis via stochastic geometry (2019)

We investigate the performance of a scheduling algorithm where the mobile terminals (MTs) may be turned off if they cause a level of interference greater than a given threshold. This approach, which is referred to as interference aware muting (IAM), may be regarded as an interference-aware scheme that is aimed to reduce the level of interference. We analyze its performance with the aid of stochastic geometry and compare it against other interference-unaware and interference-aware schemes, where the level of interference is kept under control in the power control scheme itself rather than in the scheduling process. IAM is studied in terms of average transmit power, mean and variance of the interference, coverage probability, spectral efficiency (SE), and binary rate (BR), which accounts for the amount of resources allocated to the typical MT. Simplified expressions of SE and BR for adaptive modulation and coding schemes are proposed, which better characterize practical communication systems. Our system-level analysis unveils that IAM increases the BR and reduces the mean and variance of the interference. It is proved that an operating regime exists, where the performance of IAM is independent of the cell association criterion, which simplifies the joint design of uplink and downlink transmissions.
Both Toffoli and Controlled-NOT need little help to do universal quantum computation (2002)

What additional gates are needed for a set of classical universal gates to do universal quantum computation? We answer this question by proving that any single-qubit real gate suffices, except those that preserve the computational basis. The result of Gottesman and Knill[quant-ph/9807006] implies that any quantum circuit involving only the Controlled-NOT and Hadamard gates can be efficiently simulated by a classical circuit. In contrast, we prove that Controlled-NOT plus any single-qubit real gate that does not preserve the computational basis and is not Hadamard (or its alike) are universal for quantum computing. Previously only a ``generic'' gate, namely a rotation by an angle incommensurate with pi, is known to be sufficient in both problems, if only one single-qubit gate is added.
Simulations of channel capacity and frequency reuse in multipoint LMDS systems (2003)

The results of several studies of microwave LMDS system capacity are presented. Assuming standard multi-sector hub site configuration with four sectors with alternating polarizations, and cross polarization uplinks and downlinks, the cumulative distribution of link availability in the system is calculated as a function of system loading, cross polarization rejection, and required C/(I+N) performance. Using standard methodology, fade and rain outages are also considered on every link. The results show that increasing antenna gain and cross polarization rejection increase system capacity. With an idealized system layout, and a C/(I+N) ratio of 15 dB, a system loading of greater than 90% of channels per sector is possible (a frequency reuse factor of nearly 4). For 64 QAM with a C/(I+N) ratio of 25 dB, this hub frequency reuse factor reduces to about 2.
The Heme Complex of Hmu O, a Bacterial Heme Degradation Enzyme from Corynebacterium diphtheriae (1999)

Hmu O, a heme degradation enzyme in Corynebacterium diphtheriae, forms a stoichiometric complex with iron protoporphyrin IX and catalyzes the oxygen-dependent conversion of hemin to biliverdin, carbon monoxide, and free iron. Using a multitude of spectroscopic techniques, we have determined the axial ligand coordination of the heme-Hmu O complex. The ferric complex shows a pH-dependent reversible transition between a water-bound hexacoordinate high spin neutral pH form and an alkaline form, having high spin and low spin states, with a pK(a) of 9. (1)H NMR, EPR, and resonance Raman of the heme-Hmu O complex establish that a neutral imidazole of a histidine residue is the proximal ligand of the complex, similar to mammalian heme oxygenase. EPR of the deoxy cobalt porphyrin IX-Hmu O complex confirms this proximal histidine coordination. Oxy cobalt-Hmu O EPR reveals a hydrogen-bonding interaction between the O(2) and an exchangeable proton in the Hmu O distal pocket and two distinct orientations for the bound O(2). Mammalian heme oxygenase has only one O(2) orientation. This difference and the mixed spin states at alkaline pH indicate structural differences in the distal environment between Hmu O and its mammalian counterpart.
Colorimetric characterization of the Apple studio display (Flat panel LCD) (1998)

The colorimetric characterization of a flat-panel LCD monitor, the Apple Studio Display, using traditional CRT characterization techniques was evaluated. The results showed that the display performed up to the manufacturer&apos;s specifications in terms of luminance and contrast. However, the traditional CRT gain-offset-gamma (GOG) model for characterization was inadequate and a model with one-dimensional lookup tables followed by a 3x3 matrix was developed. The LUT model performed excellently with average CIE94 color differences between measured and predicted colors of approximately 1.0.
Discovery of Brain-Penetrant, Orally Bioavailable Aminothienopyridazine Inhibitors of Tau Aggregation (2010)

Agents capable of preventing the misfolding and sequestration of the microtubule-stabilizing protein tau into insoluble fibrillar aggregates hold considerable promise for the prevention and/or treatment of neurodegenerative tauopathies such as Alzheimer's disease. Because tauopathies are characterized by amyloidosis that is restricted to the central nervous system (CNS), plausible candidate compounds for in vivo evaluation must both prevent tau fibrillization and achieve significant brain levels. Recently, we reported the discovery of the aminothienopyridazine (ATPZ) class of tau aggregation inhibitors and now describe a series of new analogues that are both effective inhibitors of tau fibrillization and display significant brain-to-plasma exposure ratios after administration to mice. Further, two of the most promising examples, 15 and 16, were found to reach significant brain exposure levels following oral administration. Taken together, these results suggest that examples from the ATPZ class hold promise as candidates for in vivo efficacy studies in animal models of neurodegenerative tauopathies.
Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma (2004)

Cirrhotic liver and HCC express SSTRs. Although the somatostatin analogues used in this study did not affect proliferation and apoptosis, stimulation of SSTR1 may decrease invasiveness of HCC by reducing migration of hepatoma cells and/or HSCs. Clinical trials evaluating somatostatin analogues for the treatment of HCC should take these findings into account.
Recent developments in the manufacture of chlorine dioxide (1958)

Abstract Fundamental studies on the kinetics of formation of chlorine dioxide have led to an hypothesis concerning the mechanism of the reactions involved. This has lead to improvements in the manufacture of this important bleaching and oxidizing agent. Older processes have been made more efficient and some new ones have been developed. A new process, patented by the author and assigned to Electric Reduction Co. of Canada Limited in Canada, and to Hooker Chemical Corporation in the United States, employing sodium chlorate, sodium chloride and sulphuric acid as raw materials, is outlined. Recent improvements in the Mathieson, Solvay and Day‐Kesting processes are reviewed, as well as the new Columbia‐Southern modifications of the Persson process. Trends in absorption tower design, in materials of construction and in bleaching with chlorine dioxide are briefly indicated.
Cloning and characterization of the determinant for abortive infection of bacteriophage from lactococcal plasmid pCI829 (1991)

The genetic determinant for abortive infection of bacteriophage (Abi) from the lactococcal plasmid pCI829 was cloned on a 6.2 kb StuI fragment in Escherichia coli using the shuttle vector pSA3. In Lactococcus lactis subsp. lactis MG1363Sm the resulting recombinant plasmid pCI816 conferred complete insensitivity to the small isometric-headed phage 712 and a reduced plaque size in the case of the prolate-headed phage c2. The determinant was further localized by subcloning and nuclease Bal31 deletion analysis; approximately 2.0 kb of DNA was essential for the expression of the Abi+ phenotype. Nucleotide sequence analysis of this region revealed a putative open reading frame of 1887 base pairs preceded by a putative promotor sequence and ribosome-binding site which exhibited similarity to consensus E. coli and Bacillus subtilis transcription/translation signals. Hybridization experiments indicated that this region was not homologous to the abi determinant from the phenotypically similar lactococcal plasmid pCI750.
Early clinical skills training (1994)

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Why does Douglas-fir heartwood turn black when treated with ammoniacal copper preservatives? (1994)

Douglas-fir heartwood often turns very dark in color when treated with ammoniacal copper preservatives. The cause of this black discoloration is unknown. Examination of the acetone-soluble extractives present in Douglas-fir heartwood led to the recovery of a white solid, which produced a black reaction product with ammoniacal copper solutions. An ultraviolet, infra red, mass spectroscopy, and proton nuclear magnetic resonance spectroscopic analysis of the white solid confirmed that it was taxifolin. The black complex was only formed with ammoniacal copper solutions, and was not produced during reactions with acidic, neutral or basic copper solutions, or ammonium hydroxide alone. Analysis of the copper complex confirmed the presence of nitrogen (...)
Some FAQs about Usage-Based Pricing (1995)

This is a list of Frequently Asked Questions about usage-based pricing of the Internet. We argue that usage-based pricing is likely to come sooner or later and that some serious thought should be devoted to devising a sensible system of usage-based pricing. This document is available on-line at http://gopher.econ.lsa.umich.edu.