gebhart/patrepeval huggingface dataset:
Multianalyte assay system developed for drugs of abuse. (1993)

A simple, 10-min immunoassay system has been developed that simultaneously screens for five different classes of drugs of abuse in a urine sample. This system tests for amphetamines, cannabinoids, cocaine metabolites, opiates, and phencyclidine, and each assay has a specific preset cutoff concentration. Accuracy is > 99% for reporting positive or negative results for samples with 200% or 50%, respectively, of the cutoff concentrations of the drugs. Tests of a panel of 96 compounds yielded only three cases of nonspecific reactivity (at a drug concentration of 100 mg/L). Another panel of 12 compounds that could normally be found in urine samples was also evaluated and no interferences were observed. Concordance was > 95% between this system and the comparable automated immunoassays for detecting drugs of abuse. Greater than 98% of GC/MS-confirmed positive samples gave positive results with this assay system.
Enabling scanning electron microscope contour-based optical proximity correction models (2015)

A scanning electron microscope (SEM) is the metrology tool used to accurately characterize very fine structures on wafers, usually by extracting one critical dimension (CD) per SEM image. This approach for optical proximity correction (OPC) modeling requires many measurements resulting in a lengthy cycle time for data collection, review, and cleaning, and faces reliability issues when dealing with critical two-dimensional (2-D) structures. An alternative to CD-based metrology is to use SEM image contours for OPC modeling. To calibrate OPC models with contours, reliable contours matched to traditional CD-SEM measurements are required along with a method to choose structure and site selections (number, type, and image space coverage) specific to a contour-based OPC model calibration. The potential of SEM contour model-based calibration is illustrated by comparing two contour-based models to reference models, one empirical model and a second rigorous simulation-based model. The contour-based models are as good as or better than a CD-based model with a significant advantage in the prediction of complex 2-D configurations with a reduced metrology work load.
LHRH neurons express cJun protein during the proestrous surge of luteinizing hormone. (1992)

LHRH neurons express cFos on the afternoon of proestrus in association with the ovulatory LH surge. This study determined whether LHRH neurons express another proto-oncogene product, Jun, during the estrous cycle. By using immunocytochemical double staining techniques, localization of Jun proteins and LHRH was compared with expression of cFos in LHRH neurons. LHRH neurons expressed Jun proteins on the afternoon of proestrus with detection of Jun through the morning of estrus. The time course of Jun expression in LHRH neurons during proestrus suggests a common stimulus for both Jun and cFos expression in LHRH neurons, with Jun proteins persisting somewhat longer than cFos. Pentobarbital, which blocks the preovulatory LH surge and cFos expression in LHRH neurons, blocked Jun expression in LHRH neurons; the LHRH neurons similarly expressed Jun and cFos on the following afternoon at the time of the expected delayed LH surge. There was a similarity in the patterns (in terms of numbers and distribution) of Jun-positive and cFos-positive LHRH neurons. Both were localized in the preoptic area and anterior hypothalamus; LHRH neurons above the anterior commissure or rostral to the OVLT did not express Jun or cFos. For the first time, these data provide direct evidence that both proto-oncogene products, Jun and cFos, are expressed in LHRH neurons in association with the proestrous LH surge. Taken together, these results suggest that changes in gene expression mediated by Jun-cFos heterodimers may accompany LHRH activation on the afternoon of proestrus.
Blood glucose regulation: an output feedback approach (2003)

Diabetes mellitus is a disease that afflicts many people. Here, an output feedback for blood glucose regulation is presented. To this end, the glucose regulation problem is seen as an output tracking problem. In this way, the proposed controller leads the glucose level from diabetic to normal behavior. The resulting controller contains two parts: (I) a state estimator and (II) a linearizing-like control law. The proposed controller yields smooth control actions. Numerical simulations show that the controller is able to reject load disturbances.
Chemistry of Enoxysilacyclobutanes: Highly Selective Uncatalyzed Aldol Additions (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of Enoxysilacyclobutanes: Highly Selective Uncatalyzed Aldol AdditionsScott E. Denmark, Brian D. Griedel, Diane M. Coe, and Mark E. SchnuteCite this: J. Am. Chem. Soc. 1994, 116, 16, 7026–7043Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ja00095a004https://doi.org/10.1021/ja00095a004research-articleACS PublicationsRequest reuse permissionsArticle Views2332Altmetric-Citations138LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Sex pheromone of processionary moths and biosystematic considerations within the genus Thaumetopoea (1990)

* INRA Centre de Recherche d'Avignon, URD, Domaine St Paul, BP 91, 84143 Montfavet cedex Diffusion du document : INRA Centre de Recherche d'Avignon, URD, Domaine St Paul, BP 91, 84143 Montfavet cedex
Sensor-Based Control of a Nine-Link Biped (1990)

We aimed to realize smooth 3D biped walking in a robot through control based on information obtained from various sensors. We employed a method to control walking by divid ing it into motions in the sagittal plane and in the lateral plane. We treated motion in the lateral plane as a regulator prob lem with two equilibrium states. We also used relatively low gain feedback coefficients obtained from the optimal regula tor theory. For motion in the sagittal plane, we put the body speed close to the smooth speed function given in advance by controlling the ankle torque. The effectiveness of the proposed control method was ex amined by computer simulation and proved by experiments with our BLR-G2 walking robot. The BLR-G2 is equipped with foot pressure and ankle torque sensors to provide infor mation about the condition of contact with the floor. The sole and ankle driving actuators undergo force/torgue feedback control based on the sensor information. These contributed toward realizing smooth walking with the sole firmly gripping the floor.
The Passion of Meter: A Study of Wordsworth's Metrical Art. Brennan O'Donnell (1996)

Book Review| September 01 1996 Review: The Passion of Meter: A Study of Wordsworth's Metrical Art., by Brennan O'Donnell The Passion of Meter: A Study of Wordsworth's Metrical Art.Brennan O'Donnell Lee M. Johnson Lee M. Johnson Search for other works by this author on: This Site PubMed Google Scholar Nineteenth-Century Literature (1996) 51 (2): 233–235. https://doi.org/10.2307/2933963 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Lee M. Johnson; Review: The Passion of Meter: A Study of Wordsworth's Metrical Art., by Brennan O'Donnell. Nineteenth-Century Literature 1 September 1996; 51 (2): 233–235. doi: https://doi.org/10.2307/2933963 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentNineteenth-Century Literature Search This content is only available via PDF. Copyright 1996 The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
Pharmacokinetic evaluation of two dosage regimens of clindamycin phosphate (1989)

Interpretation of the majority of data on the disposition of clindamycin is confounded by the presence of active metabolites, which may interfere with commonly employed bioassays. We undertook a multiple-dose study of the disposition of clindamycin phosphate and clindamycin, given either as 600 mg intravenously every 6 h or 1,200 mg intravenously every 12 h for five and three doses, respectively, in six healthy volunteers. Concentrations in serum and urine were analyzed by a specific gas chromatography assay. Maximum and minimum clindamycin concentrations in serum and the area under the serum concentration-time curve following the first dose were similar to those observed at the steady state. The mean and standard deviation of the maximum, 1-h postdose, and minimum concentrations in serum at steady state for the 600-mg dose given every 6 h were 16.8 +/- 6.0, 7.6 +/- 0.7, and 2.3 +/- 0.9 microgram/ml, whereas for the 1,200-mg dose given every 12 h they were 17.2 +/- 3.5, 9.8 +/- 1.5, and 0.6 +/- 0.3 microgram/ml, respectively. For the 12-h regimen, clindamycin concentrations in serum remained above 2 micrograms/ml for 7 h. The decay of clindamycin phosphate levels in serum was rapid, with virtually 100% of the phosphate eliminated within the first 1.5 h following the dose. Approximately 0.35 and 4.5% of the administered dose were recovered in the urine as clindamycin phosphate and clindamycin, respectively. Further pharmacokinetic evaluation of the 12-hourly dosage regimen should be done before clinical evaluation in infected patients is undertaken.
Oil sands development contributes polycyclic aromatic compounds to the Athabasca River and its tributaries (2009)

For over a decade, the contribution of oil sands mining and processing to the pollution of the Athabasca River has been controversial. We show that the oil sands development is a greater source of contamination than previously realized. In 2008, within 50 km of oil sands upgrading facilities, the loading to the snowpack of airborne particulates was 11,400 T over 4 months and included 391 kg of polycyclic aromatic compounds (PAC), equivalent to 600 T of bitumen, while 168 kg of dissolved PAC was also deposited. Dissolved PAC concentrations in tributaries to the Athabasca increased from 0.009 microg/L upstream of oil sands development to 0.023 microg/L in winter and to 0.202 microg/L in summer downstream. In the Athabasca, dissolved PAC concentrations were mostly <0.025 microg/L in winter and 0.030 microg/L in summer, except near oil sands upgrading facilities and tailings ponds in winter (0.031-0.083 microg/L) and downstream of new development in summer (0.063-0.135 microg/L). In the Athabasca and its tributaries, development within the past 2 years was related to elevated dissolved PAC concentrations that were likely toxic to fish embryos. In melted snow, dissolved PAC concentrations were up to 4.8 microg/L, thus, spring snowmelt and washout during rain events are important unknowns. These results indicate that major changes are needed to the way that environmental impacts of oil sands development are monitored and managed.
Growth characteristics of GaAs-Ga1−<i>x</i>Al<i>x</i>As structures fabricated by liquid-phase epitaxy over preferentially etched channels (1976)

In this paper, we report our studies of the liquid-phase epitaxy of GaAs and Ga1−xAlxAs single- and double-layered structures over preferentially etched channels in GaAs substrates. Results obtained indicate that various optical waveguide structures providing lateral optical confinement can be fabricated by this etch-and-fill technique. Further, it is found that the filling of the channels is dictated by surface tension of the melt rather than by preferential growth. This growth characteristic lessens the dependence of the final profile of the grown layer on the initial etched profile and makes the etch-and-fill technique particularly suitable for the fabrication of optical bends.
Development of surface coatings for air-lubricated, compliant journal bearings to 650 C (1978)

Surface coatings for an air-lubricated, compliant journal for an automotive gas turbine engine were tested to find those capable of withstanding temperatures of either 540 C (1000 F) or 650 C (1200 F). Also, the coatings have to be capable of surviving the start-stop sliding contact cycles prior to rotor lift-off and at touchdown. Selected coating combinations were tested in start-stop tests at 14 kPa (2 psi) loading for 2000 cycles at room and maximum temperatures. Specific coating recommendations are: Cdo and graphite on foil versus chrome carbide on journal up to 370 C (700 F); NASA PS-120 (Tribaloy 400, silver, and CaF2) on journal versus uncoated foil up to 540 C (1000 F); and chemically adherent Cr2O3 on journal and foil up to 650 C (1200 F). The chemically adherent Cr2O3 coating system was further tested successfully at 35 kPa (5 psi) loading for 2000 start-stop cycles.
Effects of a drag-reducing polyelectrolyte of microscopic linear dimension (Separan AP-273) on rat hemodynamics. (1987)

Separan AP-273, a polydisperse, high molecular weight (10(5)-10(7) dalton range), anionic polyacrylamide, demonstrates polymer drag reduction (Toms effect) in the flows of several substances including blood. That is, under appropriate conditions, pipe flow can be increased markedly for a given pressure gradient, sometimes threefold or more, by nanomolar concentrations of linear macropolymers. The effect of intact and degraded Separan was tested in the open-chest, anesthetized rat, and left ventricular and carotid pressures, aortic blood flow (electromagnetic flow probe on ascending aorta), and the electrocardiogram were recorded. The results indicate that aortic flow, which in control animals was about half the flow reported for conscious rats, increases markedly after injection of Separan. The effect on blood pressure after an initial fall was variable, but the slope of arterial diastolic pressure was consistently steepened. Electrocardiographic changes were unremarkable except for a slow decline in heart rate. Although secondary reflexes undoubtedly influenced the results, the primary mechanism of the polymer appears to involve a reduced resistance to flow. The results are compatible with the proposal that the Toms effect, or some variant of it, is operative in vivo under favorable conditions. If this view is correct, then Separan and two other chemically different macropolymers with similar hemodynamic effects and physical attributes, i.e., linearity and molecular lengths approaching 100 micron, might be prototypes of a novel category of cardiovascular drugs.
<i>Machine Learning, a Probabilistic Perspective</i> (2014)

Kevin P. MurphyHardcover: 1104 pagesYear: 2012Publisher: The MIT PressISBN-13: 978-0262018029I have to admit the rather embarrassing fact that Machine Learning, a Probabilistic Perspective is the f...
Radiopaque solidifying liquids for releasable balloon technique: a technical note. (1980)

Recently we have reported a catheter having a balloon which can be released simply by twisting the catheter. In the technique, 2-hydroxyethylmethacrylate (HEMA) has been used as a solidifying liquid to prevent the released balloon from deflating. Since HEMA is not radiopaque, the place and the size of the balloon cannot be visualized under an X-ray image intensifier. The present investigation involves the preparation of a radiopaque, solidifying liquid, by mixing HEMA with a suitable contrast medium such as metrizamide, sodium iothalamate or meglumine sodium iodamide. The use of HEMA-contrast medium mixtures made injection of the solidifying liquids much more controllable.
Differential stable isotope labeling of peptides for quantitation and <i>de novo</i> sequence derivation (2001)

We have demonstrated the use of per-methyl esterification of peptides for relative quantification of proteins between two mixtures of proteins and automated de novo sequence derivation on the same dataset. Protein mixtures for comparison were digested to peptides and resultant peptides methylated using either d0- or d3-methanol. Methyl esterification of peptides converted carboxylic acids, such as are present on the side chains of aspartic and glutamic acid as well as the carboxyl terminus, to their corresponding methyl esters. The separate d0- and d3-methylated peptide mixtures were combined and the mixture subjected to microcapillary high performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS). Parent proteins of methylated peptides were identified by correlative database searching of peptide tandem mass spectra. Ratios of proteins in the two original mixtures could be calculated by normalization of the area under the curve for identical charge states of d0- to d3-methylated peptides. An algorithm was developed that derived, without intervention, peptide sequence de novo by comparison of tandem mass spectra of d0- and d3-peptide methyl esters.
Measurement of Polydisperse Colloidal Suspensions with quasielastic light scattering (1991)

Abstract The measurement of polydisperse populations of colloidal particles with quasielastic light scattering (QLS) is a common and dangerous practice. Here intensity autocorrelation functions with different linewidth distributions are simulated. The simulated data are treated with the histogram and exponential sampling methods and the results are contrasted with the results of the Laplace inversion routine of Provencher. All methods work well in calculating the size distribution from noise‐free correlation functions. In analyzing noisy data the methods may produce results that bear no relation to the true size distribution. The histogram method fails to determine size distributions from noisy simulated and real correlation functions. The exponential sampling method gives a qualitative measure of the size distribution when the required resolution does not exceed the limitations set by noise theory. Provencher's routine extracts smooth unimodal distributions very accurately even from noisy correlation functions, but determination of bimodal distributions may be unreliable. The importance of taking data at many scattering angles is emphasized and experimentally determined size distributions of samples of polystyrene latex spheres measured at multiple scattering angles are presented.
Synthesis of (η5 -cyclopentadienyl)-1-(4-benzyloxycarbonyl-3,4-dihydroquinoxalin-2-yl )et hene-1,2-dithiolatocobalt(III) and (η5-cyclopentadienyl)-1-[2-(N, N -dimethylaminomethyleneamino)-3-methyl-4-oxopteridin-6-yl]ethene-1,2 -di thiolatocobalt(III) (1997)

Cobalt(III) complexes are reported in which (a) a dihydroquinoxalinylethenedithiolate ligand models the pyrazine ring oxidation level in Moco, and (b) a pteridinylethenedithiolate models the pteridine ligand in Moco.
A linearized model of a twin-T RC oscillator employing an amplitude control system with multipliers (1986)

Abstract A twin-T bridge RC oscillator with a system of amplitude control which uses multipliers can have fast amplitude transient response and low distortions simultaneously. A linear model of the amplitude control system is herein discussed and used to derive the transient response for small amplitude steps. The model indicates a dependence of the response time on the oscillator amplitude. The effect of a loop filter for further reducing total harmonic distortions (THD) is analysed. Measured results are given for an experimental oscillator with the oscillation frequency f0 = 1·45 KHz. The circuit achieved THD less than 0·035% for the output voltage amplitude Vm up to 12 V with ± 15V power supplies while maintaining transient response below eight periods for vm  5 V.
Dynamic, non-interactive key management for the bundle protocol (2010)

Secure, low-overhead key establishment is crucial to maintaining the high level of trust and security that are required many types of Delay Tolerant Networks. Existing schemes for key negotiation and exchange that are currently in use on the Internet often cannot scale to meet the environmental and technical constraints of many Delay Tolerant Networks. The few works presenting solutions to DTN key establishment have largely focused on targeted networking environments. This paper proposes a dynamic, and non-interactive scheme to facilitate secure communication in infrastructureless networks, supporting various levels of trust. Specifically, the solution presented in this paper provides a key management solution to opportunistic overlay networks using the Bundle Protocol.
Introduction of ferrocene-containing [2]rotaxanes onto siloxane, silsesquioxane and polysiloxanes via click chemistry (2012)

The reaction of N(3)(CH(2))(3)Si(OTMS)(3) (TMS = SiMe(3)) with a dialkylammonium having hexynyl group 1, [FcCH(2)NH(2)CH(2)C(6)H(4)-4-O(CH(2))(4)C≡CH]PF(6) (Fc = Fe(C(5)H(4))(C(5)H(5))), in the presence of dibenzo[24]crown-8-ether (DB24C8) and [Cu{Fe(CN)(4)}]PF(6) catalyst yielded the [2]rotaxane containing the dialkylammonium unit terminated by a bulky silyl group. Azides with a silsesquioxane group react similarly to form the corresponding [2]rotaxanes having a bulky silsesquioxane end group. The azide-functionalized polysiloxane, [-O-SiMe{(CH(2))(3)N(3)}-](n)[-O-SiMe(2)-](m) also undergoes a click reaction with 1 to produce the side chain polyrotaxane. Cyclic voltammograms of these rotaxanes and 1 [(DB24C8)1] show the Fe(II)/Fe(III) redox at the same potential, but with different current depending on their molecular weights. Addition of PdCl(2)(MeCN)(2) to a solution of the side-chain polyrotaxane forms gel which regenerates the sol upon addition of PPh(3).
Multibeam cw gas-discharge CO<sub>2</sub>laser Iglan-3 (1985)

A discussion is given of the fundamental principles underlying the construction of high-power multibeam gas-discharge lasers with diffusive cooling. An analysis is made of the constructional features of the main systems of the multibeam CO2 laser Iglan-3. The experimental dependences are given of the laser output power on the discharge current, the working gas pressure, and the composition and circulation velocity of the laser mixture. Laser output powers of 4.6 and 3.5 kW respectively were obtained on using exit mirrors of ZnSe and KCl. The gain and saturation intensity of the active medium obtained by different methods were analyzed. The laser resonator efficiency was estimated for different exit mirrors. The electrooptic laser efficiency was found to be 14% and the energy efficiency 10%. Experimental data on the laser radiation beam divergence and on the intensity distribution in different cross sections of a focused beam are presented.