gebhart/patrepeval huggingface dataset:
Measurements of trace gases and photolysis frequencies during SLOPE96 and a coarse estimate of the local OH concentration from HNO<sub>3</sub> formation (2000)

The Schauinsland Ozone Precursor Experiment (SLOPE96) campaign was conducted in June 1996 to study the physicochemical transformation of pollutants and the production of photooxidants during transport from the city of Freiburg to the Schauinsland mountain. For this purpose, chemical surface measurements were made at the entrance of the valley Großes Tal, and close to the Schauinsland summit, at 1200 m altitude on a saddle at the end of the valley. In addition, measurements of ozone, NO 2 , and meteorological parameters were made on two tethered balloons and aboard a small aircraft. This paper describes the experimental setup and the measurements of ozone, odd‐nitrogen compounds, carbonyl compounds, CO, and photolysis frequencies made during SLOPE96. The various instruments used on the different platforms were harmonized on the basis of intercomparison experiments in order to achieve a consistent picture. Large precursor concentrations from the nearby city of Freiburg are transported to Schauinsland in a valley wind system during stagnant high‐pressure conditions. These conditions occurred only on 2 days of the campaign, and only 1 day (June 5) was predictable enough to allow for deployment of the aircraft and the balloons. An OH concentration of 8 ‐ 10× 0 6 cm −3 is derived from the rate of change of HNO 3 and NO 2 on June 5 at Schauinsland (1.5–3 ppb NO 2 ; J O1 D ≈ 2 × 10 −5 s −1 ), assuming quasi steady state and a homogeneous air mass. The ozone production rate as determined from the photostationary state of NO x at Schauinsland reached maximum daily values between 15 and 60 ppb h 1 around noontime. On average, P(O 3 ) comprised about 30% of the photolysis rate of NO 2 . Similar to earlier observations at Schauinsland, a good correlation between P(O 3 ) and the product of UV radiation and precursor concentrations was found.
NADPH-sulfite reductase from Escherichia coli. A flavin reductase participating in the generation of the free radical of ribonucleotide reductase. (1993)

Protein R2, the small subunit of ribonucleotide reductase of Escherichia coli, contains an essential free radical localized to tyrosine 122 of its polypeptide chain. When this radical is scavenged by hydroxyurea, the enzyme is transformed into an inactive form, metR2. E. coli contains a NAD(P)H:flavin oxidoreductase, named Fre, absolutely required for the regeneration of the radical and the activation of metR2 into R2. Consequently, an E. coli mutant strain lacking an active fre gene is more sensitive to hydroxyurea during growth, demonstrating the physiological protective function of Fre from the loss of the radical. However, this gene is not essential, and we found that E. coli contains a second tyrosyl radical generating activity, also residing in a flavin reductase. The enzyme has been purified 200-fold to homogeneity and found to be identical to sulfite reductase. Pure sulfite reductase has the ability to catalyze the reduction of free riboflavin, FMN, or FAD by NADPH and thus, as Fre, to transfer electrons to the iron center of metR2, a key step during the activation reaction.
Evaluation of Autoscaling Metrics for (stateful) IoT Gateways (2019)

Wide adoption of Internet of Things solutions in the industry requires IoT platforms to support long-running, stateful protocols with numerous connections to ingest the measurements, and at the same time to provide the highest throughput possible to achieve service level objectives (SLOs). The challenge of providing sufficient throughput can be solved via automated horizontal scalability for IoT platforms' gateways. Firstly, to address this challenge, a study of the state-of-the-art solutions and approaches adopted in the industry to ensure predictable throughput at IoT gateways was conducted. Secondly, the following three gateways autoscaling metrics were studied on the in-house developed cloud-native IoT Platform: CPU utilization, the number of concurrent active connections, and the absolute throughput per gateway. The results of the experimental evaluation suggest the combination of rate limiting and active connection monitoring as a prerequisite for high throughput at IoT gateways.
Cellular factors controlling human L1 retrotransposition (2017)

L'abondance d'éléments génétiques mobiles dans le génome humain a un impact critique sur son évolution et son fonctionnement. Même si la plupart des éléments transposables sont inactifs en raison de l'accumulation de mutations, le rétrotransposon LINE-1 (Long Interspersed Element-1 ; ou L1) continue de se mobiliser et d'influer sur notre génome. Il a ainsi contribué à l'évolution de l'homme moderne, mais aussi à l'apparition de maladies génétiques. Les séquences du rétrotransposon L1 correspondent à 17% de la masse totale de l’ADN humain. Une copie active de L1 est capable de se mobiliser de manière autonome par un mécanisme de type «copier-coller» qui met en jeu un intermédiaire ARN et une étape de transcription inverse. Cependant, peu de choses sont connues sur les voies cellulaires impliquées dans la mobilité de L1. Notre laboratoire a découvert, par des cribles double-hybride, une interaction entre la protéine ORF2p de L1 et le récepteur α associé aux œstrogènes (ERRα), un membre de la famille des récepteurs nucléaires. Ici, nous avons confirmé et étendu cette observation à plusieurs autres membres de la superfamille des récepteurs de stéroïdes en utilisant un test de double-hybride fluorescent (F2H) en culture cellulaire. Pour mieux comprendre le rôle potentiel d’ERRα dans le cycle de rétrotransposition de L1, nous avons effectué des expériences de suppression et de surexpression qui suggèrent qu’ERRα est un régulateur positif de la rétrotransposition. Collectivement, ces données relient les voies de signalisation des stéroïdes avec la régulation post-traductionnelle de la rétrotransposition de L1, ce qui suggère un modèle par lequel ERRα et probablement autres récepteurs nucléaires peuvent recruter le RNP L1 vers des emplacements chromosomiques spécifiques.
MicroRNA 125b inhibition of B cell differentiation in germinal centers (2010)

MicroRNAs 125a and 125b are predicted to be able to bind to the B lymphocyte-induced maturation protein-1 (BLIMP-1) and IFN regulatory protein-4 (IRF-4) transcription factors, which are essential for plasma cell differentiation. A computational survey of the human and mouse genomes revealed that miR-125a and miR-125b are members of a multigene family located in paralogous clusters. The miR-125a cluster on chromosome 19 in humans includes miR-99b and let-7e, whereas the miR-125b cluster on chromosome 21 includes miR-99a and miR-let-7c. Our analysis of the expression profiles for these six miRs during B lineage differentiation indicated that mature miR-125a, miR-125b, miR-99b and let-7e transcripts are preferentially expressed by the actively dividing centroblasts in germinal centers (GC). However, miR-99b and let-7e are not predicted to bind BLIMP-1 or IRF-4 transcripts, and binding to the untranslated region of BLIMP-1 and IRF-4 messenger RNAs could be confirmed only for miR-125b. When the effect of miR-125b over-expression on terminal B cell differentiation was evaluated in an LPS-responsive B cell line, the induction of BLIMP-1 expression and IgM secretion was inhibited in this model system. Furthermore, miR-125b over-expression inhibited the differentiation of primary B cells and compromised the survival of cultured myeloma cells. These findings suggest that miR-125b promotes B lymphocyte diversification in GC by inhibiting premature utilization of essential transcription factors for plasma cell differentiation.
Fabrication and characterization of reactive ion beam etched SiC gratings (1992)

A holographic SiC grating has been fabricated by means of reactive ion beam etching in Ar+CHF3 mixture and by using photoresist as an etching mask. The etch rates of SiC and photoresist depend on the CHF3 concentration in Ar+CHF3 mixture. A maximum value for a ratio of the etch rate of SiC to that of photoresist was found to be 1.29 for 67%Ar+33%CHF3 mixture. Diffraction efficiency of an ion-beam etched grating of 1200 ℓ/mm grooves coated with Au was measured by using synchrotron radiation and the Al kα emission line from an x-ray tube. The diffraction efficiency of the first order was 4.5%–9.3% in the soft x-ray region between 8.34 and 120 Å with a small amount of the higher order and the scattered light components. In addition, it is demonstrated that SiC can be etched in SF6 gas by synchrotron radiation excitation.
Routing and switching in a wavelength convertible optical network (2002)

A wavelength-convertible switch architecture and routing algorithm for circuit-switched wavelength-division-multiplexing optical networks is studied. Wavelength converters are used to resolve wavelength conflicts and to reuse wavelengths. These converters are not dedicated to individual channels, but are shared by the channels of a node or those of an outbound link in the share-per-node or the share-per-link wavelength-convertible switch, respectively. A routing algorithm is developed to converse wavelength converters while maintaining performance close to that of a network with abundant converters. It is found that converters can improve the network performance, such as the blocking probability and fairness, considerably.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Phase I clinical trial of drug-monoclonal antibody conjugates in patients with advanced colorectal carcinoma: a preliminary report. (1989)

Melphalan (MEL), an alkylating agent, has been modified to a derivative, N-acetylmelphalan (N-AcMEL), which can be conjugated to anticolon cancer monoclonal antibodies (MoAbs 30.6, I-1, and JGT) and used for immunochemotherapy. The final immunoconjugates possess potent cytotoxicity and specificity in preclinical studies. In a phase I clinical study, N-AcMEL-MoAb conjugates were administered via the hepatic artery to 10 patients, nine of whom had disseminated colorectal cancer (including the liver) and one of whom had Dukes' C colon cancer that had been resected. The selection of MoAb was based on the immunoperoxidase staining of the primary colon cancer tissue. Thus far doses of 1000 mg/m2 MoAb conjugated to 20 mg/m2 of N-AcMEL have been administered with no significant side effects, whereas MEL unconjugated to monoclonal antibodies would have caused myelosuppression in a proportion of patients at the same dosage. Serum antimouse antibody responses were noted in all of the patients; febrile reactions were noted with higher doses but were easily controlled with antipyretics, antihistamines and, if necessary, steroids. Serum sickness developed in one patient who was given a second course of treatment in the presence of human antimouse antibody, but the episode was self-limiting. Eight of the 10 patients had evaluable disease. Subjective improvement was noted in almost all of the patients examined, and 33%, or 3 of 9, of the treatments (nine courses of treatment in eight patients with evaluable disease; one of the patients had two courses of treatment) led to antitumor responses (minor response) by objective assessment with computed tomography of the liver. It is important to note that treatment with N-AcMEL-MoAb conjugates was safe at a dose of 20 mg/m2 of N-AcMEL, whereas the efficacy of such a form of treatment remains to be determined.
Organotypic Raft Cultures as an Effective In Vitro Tool for Understanding Raman Spectral Analysis of Tissue¶ (2003)

There is a growing body of evidence showing that optical spectroscopy has the potential to be a useful in vivo diagnostic tool. Yet, so far there is no definitive cellular and biochemical understanding for the differences seen in the spectra from different tissue categories and disease states. In this study, we examine the use of organotypic raft cultures as an in vitro model of in vivo tissue conditions in an attempt to overcome some of the limitations of previously used methods. Organotypic raft cultures resembling normal and dysplastic epithelial cervical tissue were constructed and grown at an air-liquid interface for 2 weeks. Raman spectra of normal as well as dysplastic raft cultures were measured and compared with in vivo spectra from the corresponding tissue type. Histologic comparisons ensured that the raft cultures had similar structure and morphology to the corresponding intact tissue types. Raman spectra were also acquired from different layers of tissue. Spectral comparisons show that the Raman spectra of the raft cultures are similar to the spectra acquired from the cervix in vivo for both normal and dysplastic tissues. These results show that organotypic raft cultures are an effective and useful tool for the cellular and biochemical analysis of tissue spectroscopy.
Heuristic search value iteration for POMDPs (2004)

We present a novel POMDP planning algorithm called heuristic search value iteration (HSVI). HSVI is an anytime algorithm that returns a policy and a provable bound on its regret with respect to the optimal policy. HSVI gets its power by combining two well-known techniques: attention-focusing search heuristics and piecewise linear convex representations of the value function. HSVI's soundness and convergence have been proven. On some bench-mark problems from the literature, HSVI displays speedups of greater than 100 with respect to other state-of-the-art POMDP value iteration algorithms. We also apply HSVI to a new rover exploration problem 10 times larger than most POMDP problems in the literature.
Ultrashort pulse propagation, pulse breakup, and fundamental soliton formation in a single-mode optical fiber (1987)

The propagation of ultrashort (0.83 ps), intense dye laser pulses through a single-mode optical fiber is investigated. The input wavelength is tuned in the vicinity of the zero dispersion wavelength of the fiber. Although the input power is sufficient to generate solitons of up to the tenth order we do not observe the formation of high-order solitons. Instead, the input pulse breaks up temporally and spectrally after an initial stage of narrowing, and an ultrashort Stokes pulse is formed which shifts continuously to lower frequencies with increasing fiber length. The parameters of this pulse closely correspond to those of the fundamental soliton solution of the nonlinear Schroedinger equation. Using fiber lengths from a few meters up to 1 km the resulting pulse durations lie between 55 and 410 fs and the corresponding wavelengths between 1.36 and 1.54 μm. Numerical simulations solving a modified nonlinear Schroedinger equation including higher order dispersion and the Raman effect are in good agreement with the experimental results. It is shown that the principal soliton pulse shaping mechanisms are pulse narrowing and the soliton self-frequency shift.
Phage display and its application in vaccine design (2010)

This review focuses on phage display and its application in vaccine design. Four kinds of phage display systems and their characteristics are highlighted. Whole phage particles can be used to deliver vaccines by fusing immunogenic peptides to modified coat proteins (phage-display vaccination), or by incorporating a eukaryotic promoter-driven vaccine gene within the phage genome (phage DNA vaccination). Hybrid phage vaccination results from a combination of phage-display and phage DNA vaccination strategies, indicating the potential for evolution of phage vaccines. Phage vaccines could provide a key to unlock new approaches in combating bacterial and viral pathogens, and cancer diseases. New phage display systems will certainly emerge because of the global abundance of phage and our increasing ability to exploit them. The scope of phage display applications will continue to expand. Over the ensuing period, research should be directed toward a better understanding of the immunization mechanisms involved in phage-mediated immunization, and the development of hybrid phage vaccination.
Schiff Base Substituent-Triggered Efficient Deboration Reaction and Its Application in Highly Sensitive Hydrogen Peroxide Vapor Detection (2016)

The organic thin-film fluorescence probe, with the advantages of not polluting the analyte and fast response, has attracted much attention in explosive detection. Different with nitro explosives, the peroxide-based explosives are hardly to be detected because of their poor ultraviolet absorption and lack of an aromatic ring. As the signature compound of peroxide-based explosives, H2O2 vapor detection became more and more important. Boron ester or acid is considered to be a suitable functional group for the detection of hydrogen peroxide due to its reliable reactive activity. Its only drawback lies on its slow degradation velocity. In this work, we try to introduce some functional group to make the boron ester to be easily oxidized by H2O2. Herein, 4-(phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amino)benzaldehyde (OTB) was synthesized and its imine derivatives, OTBXAs, were easily obtained just by putting OTB films in different primary amines vapors. OTBXAs show fast deboronation velocity in H2O2 vapor compared with OTB. The complete reaction time of (E)-N-phenyl-4-((propylimino)methyl)-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)aniline (OTBPA) was even shortened 40 times with a response time of seconds. The detection limit for H2O2 vapor was as low as 4.1 parts per trillion (ppt). Further study showed that it is a general approach to enhance the sensing performance of borate to hydrogen peroxide (H2O2) vapor by introducing an imine into an aromatic borate molecule via a solid/vapor reaction.
Exploratory Application of Augmented Reality/Mixed Reality Devices for Acute Care Procedure Training (2018)

Investigators implemented a core holoimaging pipeline infrastructure and modular open-access repository to generate and enable access to modular holoimages during exploratory pilot stage applications for invasive procedure training that featured innovative AR/MR techniques on off-the-shelf headset devices.
Shear Failure Modes of Reinforced Concrete Members with High-Strength Materials (2006)

We examined the ability of trigeminal nerve activation to induce cortical spreading depression in rats. Capsaicin was injected into the bilateral plantar or whisker pad for either 4 or 6 days in rats. The number and duration of cortical spreading depressions induced by potassium were significantly increased in animals injected with capsaicin in the bilateral whisker pad compared with animals injected in the bilateral plantar or in controls, while administration of a GABAA receptor agonist decreased these effects. Repetitive nociceptive stimulation of the trigeminal nerve lowers the threshold for the induction of cortical spreading depression by altering GABAergic neuronal activity.
Two-color Photoactivatable Probe for Selective Tracking of Proteins and Cells (2010)

We report the development and application of photoactivatable Green Cherry (G(PA)C), the first genetically encoded "continuously red-photoactivatable green" two-color probe for live cell imaging. G(PA)C is unique in that it enables real-time tracking of selected subpopulations of proteins and organelles in the cell or of cells within tissues and whole organisms, with constant reference to the entire population of the probe. Using G(PA)C-zyxin as proof of utility, we obtained new insights into the dynamic movement of the cytoskeletal protein zyxin. We show that zyxin is continuously and rapidly recruited from the cytosol into established focal adhesions. It can also move rapidly within a given focal adhesion and "hop" between adjacent focal adhesions, emphasizing the dynamic nature of proteins within these structures. The in vivo utility of G(PA)C is exemplified by tracking hemocyte movements using a versatile transgenic Drosophila model engineered to express G(PA)C in tissues and cells of interest under the control of the GAL4-inducible promoter.
The properties of <i>a</i>-C:H films deposited by plasma decomposition of C2H2 (1990)

Diamondlike a-C:H films have been deposited by plasma decomposition of C2 H2. 50 samples were prepared with a systematic variation of the deposition parameters: the substrate bias voltage was between −100 and −1400 V and the C2 H2 gas pressure was between 4×10−4 and 2.6×10−1 mbar. The following properties of the films were measured: the density by Rutherford backscattering, the total concentration of hydrogen by elastic recoil detection, the bonding ratio sp3 /sp2 by infrared spectroscopy, the internal stress by the bending beam method, and the hardness with a Knoop microhardness tester. It has been shown that the hardness and other mechanical properties cannot be correlated to the average carbon coordination number mc. This is because mc is calculated under the assumption of a homogenous single-phase model, which does not seem to be justified. It is demonstrated that the mechanical properties can be explained by the application of a void model.
Synthesis and Antipancreatitis Activities of Novel N-(2-Sulfonylamino-5-trifluoromethyl-3-pyridyl)carboxamide Derivatives as Phospholipase A2 Inhibitors. (1995)

Novel N-(2-sulfonylamino-5-trifluoromethyl-3-pyridyl)carboxamide derivatives have been prepared and evaluated as phospholipase A2 (PLA2) inhibitors. Among these compounds, IS-741 (sodium salt of 1j), which showed the highest and the most stable therapeutic effect on acute hemorrhagic pancreatitis induced by the closed duodenal loop method in rats, was selected as a candidate for further development.
Magnetic resonance imaging of the cardiovascular system: present state of the art and future potential (1988)

State-of-the-art magnetic resonance imaging (MRI) generates high-resolution images of the cardiovascular system. Conventional MRI techniques provide images in six to ten minutes per tomographic slice. New strategies have substantially improved the speed of imaging. The technology is relatively expensive, and its cost-effectiveness remains to be defined in relation to other effective, less expensive, and noninvasive technologies, such as echocardiography and nuclear medicine. The ultimate role of MRI will depend on several factors, including the development of specific applications such as (1) noninvasive angiography, especially of the coronary arteries;(2) noninvasive, high-resolution assessment of regional myocardial blood flow distribution (e.g., using paramagnetic contrast agents); (3) characterization of myocardial diseases using proton-relaxation property changes; and (4) evaluation of in vivo myocardial biochemistry. The three-dimensional imaging capability and the ability to image cardiovascular structures without contrast material give MRI a potential advantage over existing noninvasive diagnostic imaging techniques. This report analyzes current applications of MRI to the cardiovascular system and speculates on their future.