gebhart/patrepeval huggingface dataset:
Polysilane Bilayer uv Lithography (1984)

Polysilanes are a class of Si-Si backbone polymers that have been demonstrated to function as high resolution positive resists with excellent uv sensitivity. These materials have a unique photochemistry with high quantum yields and nonlinear bleaching. Polysilanes serve as excellent RIE barriers for bilevel resist applications because a protective layer of SiO<sub>2</sub> is formed during exposure to an oxygen plasma. Aliphatic polysilanes have been applied to full wafer mid-uv lithography with 0.75 μm resolution.
Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia (2008)

The objective of this study was to non-invasively assess cardiac autonomic control in subjects with sickle cell anemia (SCA) by tracking the changes in heart rate variability (HRV) that occur following brief exposure to a hypoxic stimulus. Five African-American SCA patients and seven healthy control subjects were recruited to participate in this study. Each subject was exposed to a controlled hypoxic stimulus consisting of five breaths of nitrogen. Time-varying spectral analysis of HRV was applied to estimate the cardiac autonomic response to the transient episode of hypoxia. The confounding effects of changes in respiration on the HRV spectral indices were reduced by using a computational model. A significant decrease in the parameters related to parasympathetic control was detected in the post-hypoxic responses of the SCA subjects relative to normal controls. The spectral index related to sympathetic activity, on the other hand, showed a tendency to increase the following hypoxic stimulation, but the change was not significant. This study suggests that there is some degree of cardiovascular autonomic dysfunction in SCA that is revealed by the response to transient hypoxia.
Operational Security Requirements for Large Internet Service Provider (ISP) IP Network Infrastructure (2004)

This document defines a list of operational security requirements for
the infrastructure of large Internet Service Provider (ISP) IP
networks (routers and switches). A framework is defined for specifying
profiles, which are collections of requirements applicable to
certain network topology contexts (all, core-only, edge-only...). The
goal is to provide network operators a clear, concise way of
communicating their security requirements to vendors. This memo
provides information for the Internet community.
Abstract 19652: Etv2/mir-130a/pdgfra Pathway Regulates Endothelial Lineage Specification (2014)

MicroRNAs (small non-coding RNAs) are known to regulate critical developmental stages during embryogenesis. In the present studies, we examined the role of the Etv2-miR-130a regulatory cascade and mesodermal specification. Conditional ablation of Dicer in the mesodermal derivatives including Mesp1-, Flk1- or Etv2-expressing precursors resulted in embryonic lethality. Deletion of Dicer in the endothelial progenitors resulted in embryos with impaired vascular plexuses, hemorrhage, and edema. We identified miR-130a as a direct target of Etv2 and demonstrated that it mediates endothelial lineage commitment. Forced overexpression of miR-130a promoted the endothelial program, whereas knockdown of miR-130a resulted in perturbed vascular branching and patterning and had no effect on the hematopoietic lineages. Furthermore, we demonstrated that miR-130a directly targets Pdgfra and promotes the endothelial program. This is the first report of a miRNA, which specifically promotes the divergence of a common progenitor to the endothelial lineage. Moreover, these studies enhance our understanding of the regulatory cascades that govern embryogenesis. Key words: Lineage specification, vascular development, Etv2, miR-130a, Dicer
Effect of Solution Treatment on Tensile Properties of AA2024 Matrix Composite Reinforced with Magnesium Borate Whisker (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Characterization of yeast U1 snRNP A protein: identification of the N-terminal RNA binding domain (RBD) binding site and evidence that the C-terminal RBD functions in splicing. (1996)

The yeast U1A protein is a U1 snRNP-specific protein. Like its human counterpart (hU1A), it has two conserved RNA binding domains (RBDs). The N-terminal RBD is quite different from the human protein, and a binding site on yeast U1 snRNA is not readily apparent. The C-terminal RBD is of unknown function. Using in vivo dimethyl sulfate (DMS) protection of mutant strains, we defined a region in yeast U1 snRNA as the likely U1A N-terminal RBD binding site. This was confirmed by direct in vitro binding assays. The site is very different from its vertebrate counterpart, but its location within yeast U1 snRNA suggests a conserved structural relationship to other U1 snRNP components. Genetic studies and sensitive in vivo splicing measurements indicate that the yeast U1A C-terminal RBD also functions in pre-mRNA splicing. We propose that the N-terminal RBD serves to tether the splicing-relevant C-terminal RBD to the snRNP.
A K‐<i>ras</i> 13GLY → ASP mutation is recognized by HLA‐DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation? (1994)

We have characterized and described in detail 2 CD4+ T-lymphocyte clones (TLC) from a colonic cancer patient. These TLC specifically recognize a K-ras-derived peptide carrying the 13Asp mutation commonly found in adenocarcinomas of the colon. The TLC were independently derived, as they carried 2 different T-cell receptors. The TLC recognized partly overlapping epitopes within the 13Asp peptide, presented by HLA-DQ7 molecules, suggesting that this molecule might confer some protective immunity against the mutation. On the basis of analysis of 251 colonic carcinomas, the presence of HLA-DQ7 did not seem to protect against the establishment of carcinomas carrying the 13Asp mutation, since the frequency of the DQ7 haplotype was not decreased among patients having this mutation. A modifying effect of DQ7 on the development of carcinomas with a 13Asp mutation was, however, observed, resulting in fewer tumours reaching advanced Dukes stages when DQ7 was present.
Distribution Patterns of Inorganic Mercury and Methylmercury in Tissues of Rice (<i>Oryza sativa L.</i>) Plants and Possible Bioaccumulation Pathways (2010)

Whole rice plants (Oryza sativa L.) were collected at different typical mercury (Hg) contaminated sites during regular harvest periods to investigate the distribution of inorganic mercury (IHg) and methylmercury (MeHg) in tissues. The whole rice plants were divided into rice seed (brown rice), hull, root, stalk and leaf. Elevated IHg and MeHg concentrations were observed in rice plants cultivated in Hg mining area compared to those obtained from the control site, which attributed to the Hg contamination of soil compartments by the historical large-scale Hg mining/smelting and ongoing artisanal Hg smelting activities. Our observations showed that Hg in ambient air was the potential source of IHg to the above ground parts, whereas IHg concentrations in root were restricted to Hg concentrations in paddy soil. The rice seed has the highest ability to accumulate MeHg compared to the other tissues. MeHg in paddy soil is a potential source to tissues of rice plant. Our study suggested that newly deposited Hg is comparatively more easily methylated than old mercury in soil.
A Prospective, Nonrandomized Study of Iontophoresis, Wrist Splinting, and Antiinflammatory Medication in the Treatment of Early-Mild Carpal Tunnel Syndrome (1994)

Carpal tunnel syndrome (CTS) has become the industrial epidemic syndrome of the decade and its incidence is continuing to rise. Because of public awareness. CTS is being diagnosed much earlier in the course of the disease. Iontophoresis of dexamethasone sodium phosphate has been used for years in the treatment of many musculoskeletal inflammatory disorders and clinicians have reported using this modality in the treatment of CTS. Iontophoresis is a method of transdermal administration of ionized drugs in which electrically charged molecules are propelled through the skin by an external electrical field. However, conditions of treatment and evaluation have not been standardized. A prospective, nonrandomized study utilizing a standardized treatment protocol incorporating wrist splinting with nonsteroidal antiinflammatory medications and iontophoresis of dexamethasone sodium phosphate revealed a success rate comparable with splinting plus injection of dexamethasone into the carpal tunnel space. In a 6-month follow-up of 23 cases (hands) of early-mild CTS, 4 of 23 hands (17%) were successfully treated with splints plus nonsteroidal antiinflammatory medications alone. Of those that failed this treatment program and chose to proceed with iontophoresis of dexamethasone, 11 of 19 hands (58%) had a positive response rate to iontophoresis, leaving a combined failure rate (failing both splints, nonsteroidal antiinflammatory medications and iontophoresis) of 35%. Iontophoresis may become an alternative to steroid injections to the carpal tunnel region if further studies substantiate these findings. It provides an excellent complication and side-effect profile compared with other methods of delivering dexamethasone. No complications occurred (including no significant elevation of serum glucose in insulin-dependent diabetics.)
Lag Angle Compensation in a Space Borne Scanning Lidar (1992)

The so-called 'lag angle' is inherent in any spaceborne scanning lidar system. It is also important in systems where the scanning causes a significant pointing error during the laser interrogating pulse echo time. In a heterodyne lidar system, the lag angle, if uncompensated, will significantly reduce the signal-to-noise ratio. An investigation of lag angle is presented.
Nanosponges – a completely new nano-horizon: pharmaceutical applications and recent advances (2012)

In recent years, nanosponges (NS) have gained tremendous impetus in drug delivery through nanotechnology. Nanosponges are capable of providing solutions for several formulation related problems. Through this review, scientists working in the field of nanotechnology can have an insight into the techniques of preparation, characterization and applications of NS. Owing to their small size and porous nature they can bind poorly-soluble drugs within their matrix and improve their bioavailability. They can be crafted for targeting drugs to specific sites, prevent drug and protein degradation and prolong drug release in a controlled manner. This review attempts to elaborate different schemes of synthesis of NS and their characterization. Factors affecting drug loading and release have been enumerated. Due to their advantages, NS have not only been explored for their pharmaceutical applications but also have large popularity in allied sciences, especially in water purification.
Rac-dependent Anti-apoptotic Signaling by the Insulin Receptor Cytoplasmic Domain (1999)

Mutations in the cytoplasmic domain of the insulin receptor that block the ability of the receptor to stimulate glucose uptake do not block the receptor's ability to inhibit apoptosis (Boehm, J. E., Chaika, O. V., and Lewis, R. E. (1998) J. Biol. Chem. 273, 7169-7176). To characterize this survival pathway we used a chimeric receptor (CSF1R/IR) consisting of the ligand-binding domain of the colony-stimulating factor-1 receptor spliced to the cytoplasmic domain of the insulin receptor and a mutated version of the chimeric receptor containing a 12-amino acid deletion of the juxtamembrane domain (CSF1R/IRDelta960). In addition to the inhibition of apoptosis, activation of either the CSF1R/IR or the CSF1R/IRDelta960 rapidly induced membrane ruffling in Rat1 fibroblasts. The small GTPase Rac mediates membrane ruffling. Activated and dominant-inhibitory mutants of Rac and other small GTPases were expressed in Rat1 fibroblasts to examine a potential link between the intracellular pathways that induce membrane ruffling and promote cell survival. The anti-apoptotic action of the CSF1R/IRDelta960 was reversed by dominant-inhibitory Rac(N17), but not by Ras(N17) or Cdc42(N17). Activated Rac(V12), but not Ras(D12) or Cdc42(V12), promoted cell survival in the absence of insulin. These data implicate Rac as a mediator of an unique anti-apoptotic signaling pathway activated by the insulin receptor cytoplasmic domain.
The pills that ate your profits. (1998)

It pays to pay attention to drug costs, as prescription outlays rise as much as 20 percent a year at many health plans. Despite a wave of direct-to-consumer ads for pricey new meds, HMOs are fighting back by cutting the number of drugs they'll pay for and hiking copays, among other strategies.
NEUROCHEMISTRY OF THE SPINAL CORD IN CONGENITAL TREMOR OF PIGLETS (TYPE AII), A SPINAL DYSMYELTMOGENESIS OF INFECTIOUS ORIGIN (1976)

Abstract— In piglets affected with congenital tremor type AII the CNS was not morphologically underdeveloped; spinal cord weight, total DNA content and fat‐free dry matter differed little from control values. However the total lipid extractable from affected spinal cords was only about 63% of values established for normal newborn piglets. In particular, the cerebroside content (a myelin‐specific lipid) was reduced to about 30% of the ‘normal’ value. This was parallelled by the results of an in vitro assay of cerebroside synthesis from [ 3 H]galactose which indicated a metabolic impairment. The altered fatty acid profile of isolatcd cerebrosides further suggested a derangement of fatty acid synthesis. Unlike the spinal cords of normal newborn piglets, tissues from affected piglets contained significant amounts of cholesterol esters carrying the characteristic fatty acids associated with demyelination. This implied that the reduced quantities of possibly abnormal myelin were unstable. Abnormal swollen oligodendrocytes were commonly present in the spinal cords of affected piglets and this was consistcnt with the observed impairment of myelin formation.
Identifying children with high mortality risk. (1999)

This issue reports selected results from a comprehensive study of infant and child mortality based on the National Family Health Survey data. The analysis distinguishes between neonatal, postneonatal, infant and child mortality since mortality and its causes vary considerably among children of different ages. Hazard regression analysis was used to estimate the effects of each individual variable as the factors that affect infant and child mortality tend to be correlated with each other. The study involves adjusted effects of selected socioeconomic and demographic characteristics on neonatal, postneonatal, infant, and child mortality for children born during the survey. Short birth intervals have a great effect on infant and child mortality. A previous birth interval of less than 24 months increases child mortality by about 67%. Neonatal mortality is highest among children of very young mothers. Child mortality is higher for girls in all states except Tamil Nadu, Kerala, and Goa. Seven groups of children who are especially vulnerable to infant and child mortality were identified. Thus, intervention programs, such as efforts to provide supplemental nutrition and basic immunization to pregnant mothers, infants and young children need to focus on these high-risk groups. Results for many states show elevated mortality rates for girls after the neonatal period. Family health programs aimed at overall improvement in mortality levels should pay attention to providing basic health care and supplemental nutrition to girls.
Single Hemagglutinin Mutations That Alter both Antigenicity and Receptor Binding Avidity Influence Influenza Virus Antigenic Clustering (2013)

The hemagglutination inhibition (HAI) assay is the primary measurement used for identifying antigenically novel influenza virus strains. HAI assays measure the amount of reference sera required to prevent virus binding to red blood cells. Receptor binding avidities of viral strains are not usually taken into account when interpreting these assays. Here, we created antigenic maps of human H3N2 viruses that computationally account for variation in viral receptor binding avidities. These new antigenic maps differ qualitatively from conventional antigenic maps based on HAI measurements alone. We experimentally focused on an antigenic cluster associated with a single N145K hemagglutinin (HA) substitution that occurred between 1992 and 1995. Reverse-genetics experiments demonstrated that the N145K HA mutation increases viral receptor binding avidity. Enzyme-linked immunosorbent assays (ELISA) revealed that the N145K HA mutation does not prevent antibody binding; rather, viruses possessing this mutation escape antisera in HAI assays simply by attaching to cells more efficiently. Unexpectedly, we found an asymmetric antigenic effect of the N145K HA mutation. Once H3N2 viruses acquired K145, an epitope involving amino acid 145 became antigenically dominant. Antisera raised against an H3N2 strain possessing K145 had reduced reactivity to H3N2 strains possessing N145. Thus, individual mutations in HA can influence antigenic groupings of strains by altering receptor binding avidity and by changing the dominance of antibody responses. Our results indicate that it will be important to account for variation in viral receptor binding avidity when performing antigenic analyses in order to identify genuine antigenic differences among influenza virus variants.
Solid-phase synthesis of a fucosylated glycopeptide of human factor IX with a fucose-α-(1→O)-serine linkage (1995)

The chemical synthesis of a glycopeptide with L-fucose directly linked to the hydroxy group of L-serine is reported. Two building blocks containing a protected and an unprotected fucose residue α-glycosidically linked to Nα-Fmoc-Ser-OH were prepared and used in the synthesis of a glycopeptide fragment of the EGF domain of Human Factor IX 55–65. It was demonstrated that both building blocks were completely compatible with the standard Fmoc-based solid-phase peptide synthesis protocol and furthermore that OH protection of the carbohydrate is necessary only during the final acid treatment for cleavage of the glycopeptide from the resin.
Fast Polarization Effects in Optical Aerial Cables Caused by Lightning and Impulse Current (2004)

The effects of lightning and impulse currents on the perturbations of the state of polarization (SOP) of optical beams transmitted on aerial cables are emulated in a laboratory environment. Submicrosecond-resolved measurements enable us to distinguish and quantify the magnetooptic contributions due to the discharge current. The maximum of Faraday-induced circular birefringence associated to natural strokes is estimated in /spl Delta/n/sub lr//spl ap/10/sup -7/ and may lead in a few microseconds to iterate swapping between orthogonal SOPs. The corresponding peak in relative phase delay, cumulated in transmission along a span, is evaluated as /spl Delta//spl tau//sub lr//spl ap/0.3 ps.
Separation and Configuration of<u>Syn</u>and<u>Anti</u>Isomers of Testosterone Oxime (1978)

Abstract The syn and anti isomers of testosterone oxime, prepared with hydroxylamine hydrochloride in pyridine were separated on sulfoethyl Sephadex LH-20 in methanol. The predominant isomer had the highest mobility on the cation exchanger and the longest retention time when analyzed as the trimethylsilyl ether derivative on a glass capillary column coated with SE-30. Proton NMR spectra showed that the major isomer had a 4-anti and the minor isomer a 4-syn configuration. Key Words: Steroid oximesion exchangechromatographyproton
Abnormal Retinal Function Associated With Isotretinoin Therapy for Acne (1986)

Three of 50 patients treated with isotretinoin (1 mg/kg/day) for cystic acne complained of poor night vision and/or excessive glare sensitivity. While still receiving the drug or shortly thereafter, two patients were found to have abnormal dark-adaptation curves, with elevations of either cone or rod thresholds, or both. Two patients had abnormal electroretinograms (ERGs). One had a mildly abnormal electro-oculogram. The dark-adaptation curves were normal for one patient several months after isotretinoin therapy was discontinued. Two patients had elevated cone thresholds at least one year later. Six months following cessation of therapy, the ERG was still abnormal for one patient, but continued improvement was evident at 25 months; for the second patient, the ERG was normal at one year. Analysis of Naka-Rushton parameters for the ERG scotopic b-wave stimulus-response curves indicated response compression for two patients, as evidenced by a reduction in the maximum response. For one patient, the half-saturation constant was elevated 0.7 log units, suggesting reduction of retinal sensitivity, perhaps from decrease in retinal photopigment concentration. We suspect that isotretinoin may complete for normal retinol binding sites on cell surfaces or transport molecules. A prospective study is currently underway to determine if a clinically measurable adverse effect on retinal function is seen with greater frequency.
Fire resistant natural ester dielectric fluid and novel insulation system for its use (1999)

Insulation systems for electrical power and distribution transformers are being re-evaluated based on total owning cost from both economic and risk exposure perspectives. A developed high fire point dielectric fluid, based on natural esters, has superior safety, environmental, and health properties compared to current dielectric fluids. An insulation system developed for this fluid addresses the lower inherent resistance of esters to oxidation. Accelerated transformer life testing compares transformers using standard mineral oil to those with the natural esters dielectric system. Results of these accelerated life tests show the ester fluid to be suitable for transformer use and suggest the possibility of extended insulation life compared to mineral oil systems.
ChemInform Abstract: The Use of Substituted Cyclohexadienediols as Versatile Chiral Synthons (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Anonymous proxy re‐encryption (2011)

ABSTRACT Proxy re‐encryption (PRE) is a public key encryption that allows a semi‐trusted proxy with some information (a.k.a., re‐encryption key) to transform a ciphertext under one public key into another ciphertext under another public key. Because of this special property, PRE has many applications, such as the distributed file system. Some of these applications demand that the underlying PRE scheme is anonymous under chosen‐ciphertext attacks (CCAs); that is, the adversary cannot identify the recipient of the original/transformed ciphertext, even if it knows the PRE key and can launch the CCA. However, to the best of our knowledge, none of the existing PRE schemes satisfy this requirement. In this work, we propose the first anonymous PRE with CCA security and collusion resistance. Our proposal is proved in the random oracle model based on the DDH assumption. Copyright © 2011 John Wiley & Sons, Ltd.