gebhart/patrepeval huggingface dataset:
Czapek-Dox agar containing iprodione and dicloran as a selective medium for the isolation of Fusarium species (1987)

Journal Article Czapek‐Dox agar containing iprodione and dicloran as a selective medium for the isolation of Fusarium species Get access M. P. ABILDGREN, M. P. ABILDGREN *Department of Biotechnology, Building 221, The Technical University of Denmark, DK‐2800 Lyngby Search for other works by this author on: Oxford Academic Google Scholar F. LUND, F. LUND *Department of Biotechnology, Building 221, The Technical University of Denmark, DK‐2800 Lyngby Search for other works by this author on: Oxford Academic Google Scholar U. THRANE, U. THRANE *Department of Biotechnology, Building 221, The Technical University of Denmark, DK‐2800 Lyngby†Biotechnical Section, Engineering Academy of Denmark, DK‐2800 Lyngby Search for other works by this author on: Oxford Academic Google Scholar SUSANNE ELMHOLT SUSANNE ELMHOLT ‡Danish Research Center for Plant and Soil Science, Flakkebjerg, DK‐4200 Slagelse, Denmark*Department of Biotechnology, Building 221, The Technical University of Denmark, DK‐2800 Lyngby Search for other works by this author on: Oxford Academic Google Scholar Letters in Applied Microbiology, Volume 5, Issue 4, 1 October 1987, Pages 83–86, https://doi.org/10.1111/j.1472-765X.1987.tb01620.x Published: 01 October 1987 Article history Received: 19 July 1987 Accepted: 04 August 1987 Published: 01 October 1987
Transmission system for 8K Super Hi-Vision satellite broadcasting (2014)

Test broadcasting of 8K Super Hi-Vision will be launched in Japan some time in 2016. We have developed a new transmission system for 8K Super Hi-Vision satellite broadcasting that increases transmission capacity by lowering the roll-off factor to 0.03 and increasing the symbol-rate to 33.7561 Mbaud in a 34.5-MHz channel bandwidth. Moreover, the use of 16APSK and an LDPC coding rate of 7/9 achieves a channel capacity of about 100 Mbps in a single satellite transponder. First, we describe the technical specifications and architecture of this system. Second, we describe a prototype transmitter and receiver that meet the technical specifications and show the basic performance of this equipment. Third, we report the results of tests of the hardware using a Communication Satellite (CS) and Broadcasting Satellite (BS) in Japan. Finally, we give an outlook for practical realization of 8K Super Hi-Vision satellite broadcasting in Japan.
Advanced Metal Gate/High-K Dielectric Stacks for High-Performance CMOS Transistors (2004)

We have successfully engineered n-type and p-type metal electrodes with the correct work functions on high-K gate dielectrics for high-performance CMOS applications. The resulting metal gate/high-K dielectric stacks have i) equivalent oxide thickness (EOT) of 1.0nm with negligible gate oxide leakage, ii) desirable transistor threshold voltages for n- and p-channel MOSFETs, and iii) transistor channel mobilities close to those of SiO2. The CMOS transistors fabricated with these advanced metal gate/high-K dielectric stacks achieve the expected high drive current performance. 2.
The effect of hypoxia on photocytotoxicity of TICS tricarbocyanine dye in vitro. (2006)

Photosensitizing effect of TICS is only partially dependent on the oxygenation of tumor cells.
Producing usable fuel from municipal solid waste (1995)

Refuse disposal is a matter of increasing concern for municipalities and state governments. As existing land-fills become filled to capacity, and new landfills become more costly to site, it has become critical to develop alternative disposal methods. Some of the refuse that is presently being landfilled has the potential to provide considerable quantities of energy and thereby replace conventional fossil fuels. Another environmental concern is the problem of the emissions associated with combustion of traditional fossil fuels. The Clean Air Act Amendments of 1990 significantly restrict the level of sulfur dioxide (SO{sub 2}) and nitrogen oxides (NO{sub x}) emissions permissible as effluent from combustion facilities. To address both of these concerns, Argonne National Laboratory, under sponsorship of the U.S. Department of Energy (DOE), has developed a means of producing fuel from municipal solid waste that can be co-fired with coal to supplement coal supplies and reduce problematic emissions.
Clonal nature of the immune response to phosphorylcholine. II. Idiotypic specificity and binding characteristics of anti-phosphorylcholine antibodies. (1974)

The clonal nature of the immune response to phosphorylcholine (PC) was studied at the level of the antibody-producing cell (PFC) with the highly sensitive parameters of idiotypes and binding characteristics as specific markers. As a basis for comparison, the characteristics of the anti-PC IgM antibody produced in different inbred strains of mice were related in PFC inhibition assays with those exhibited by four different PC-binding myeloma proteins, HOPC 8, M c PC 603, MOPC 167, and MOPC 511. Each of these myelomas possesses distinctly different idiotypic determinants and binding affinities for PC, glycerophosphorylcholine (GPC) and choline (C). The induced anti-PC antibody in each of the strains tested was solely of the IgM class and bound PC τ; GPC τ; C. In BALB/c and A, but not CBA, no affinity maturation occurred during the immune response which indicates a restriction in the affinity heterogeneity. As determined from the PFC inhibition profiles, BALB/c and A strain anti-PC antibody had the same binding characteristics as HOPC 8 and that of BALB/c possessed the idiotypic determinants of this myeloma protein. As shown in a previous paper, the receptors on PC-specific antigen-binding cells (ABC) possessed the identical characteristics of class, specificity, and idiotypes as shown by the secreted antibody. These results, therefore, provide evidence for a direct link between the antibody secreted by PFC and the receptor molecules on ABC.
Thin Hybrid Metamaterial Slab With Negative and Zero Permeability for High Efficiency and Low Electromagnetic Field in Wireless Power Transfer Systems (2017)

Current wireless power transfer (WPT) systems have limited charging distance and high induced electromagnetic field (EMF) leakage. Thus, we first proposed a thin printed circuit board (PCB) type hybrid metamaterial slab (HMS) combining two kinds of metamaterial cell structures. The metamaterial cells in the center area of the HMS have zero relative permeability and straighten the magnetic field direction. The metamaterial cells located at the edges of the HMS have negative relative permeability and change the outgoing magnetic fields to opposite direction by magnetic boundary condition. Therefore, the magnetic field can be more confined between transmitter and receiver coils, enhancing the power transfer efficiency, while decreasing the EMF leakage in a WPT system. In this paper, we demonstrated that increased power transfer efficiency from 34.5% to 41.7% and reduced EMF leakage from -19.21 to -26.03 dBm in 6.78-MHz WPT system. Furthermore, we proposed new analysis method for relative permeability measurement of the metamaterial using a novel cubic structure with perfect electrical conductor and perfect magnetic conductor boundary.
Reactivated and latent varicella-zoster virus in human dorsal root ganglia. (1995)

Ganglia obtained at autopsy were examined by in situ hybridization from one patient with zoster (also called herpes zoster or shingles), two varicella-zoster virus (VZV)-seropositive patients with clinical evidence of zoster, one VZV-seronegative child, and one fetus. Ganglia positive for VZV had a hybridization signal in both neuronal and nonneuronal satellite cells. Ganglia obtained from the fetus and from the seronegative infant were consistently negative for VZV. Two striking observations were evident regarding the presence of VZV DNA in ganglia obtained from the individual with zoster at the time of death. First, ganglia innervating the sites of reactivation and ganglia innervating adjacent sites yielded strongly positive signals in neurons and satellite cells, whereas ganglia from distant sites were rarely positive. Second, VZV DNA was found in both the nuclei and the cytoplasm of neurons innervating areas of zoster. However, in neurons innervating zoster-free areas, VZV DNA was found only in the nucleus of neurons and their supporting satellite cells. Immunohistochemistry with a fluorescent monoclonal antibody to the VZV glycoprotein gpI, a late virus protein, revealed a positive signal in the cytoplasm of ganglia with clinical evidence of reactivation. These results illustrate that both neuronal and satellite cells become latently infected following primary VZV infection. The presence of VZV DNA and gpI in the cytoplasm of neurons demonstrates productive infection following reactivation at the site of latency.
The Selenium and Vitamin E Cancer Prevention Trial (2009)

Prostate cancer is an attractive and appropriate target for primary prevention because of its incidence, prevalence, and disease-related mortality. Despite PSA-induced stage migration, a high cure rate for localized disease, and improved understanding of prostate cancer biology, most men who develop metastatic disease are still destined to die of prostate cancer. It seems self-evident that an effective prevention strategy would spare many men from this burden of diagnosis and cure. The molecular pathogenesis of prostate cancer also lends itself to a primary prevention strategy. Clinically evident prostate cancer is rare in men $<$ 50 years old, while the precancerous lesion PIN (prostatic intraepithelial neoplasia) is apparent at autopsy in men $<$ 30. Furthermore, the prevalence of PIN is similar in populations at much different risks of developing clinically evident cancer, suggesting that external environmental influences are important and potentially modifiable. This chapter will review the scientific and epidemiologic evidence supporting the role of selenium and vitamin E in the prevention of prostate cancer and the design of the Selenium and Vitamin E Cancer Prevention Trial.
Genetic Modifiers of Lung Disease in Cystic Fibrosis (2005)

Genetic variation in the 5' end of TGFbeta1 or a nearby upstream region modifies disease severity in cystic fibrosis.
Isolation and characterization of the inositol trisphosphate receptor from smooth muscle. (1990)

The release of Ca2+ from internal stores is requisite to muscle contraction. In skeletal muscle and heart, the Ca2+ release channels (ryanodine receptor) of sarcoplasmic reticulum, involved in excitation-contraction coupling, have recently been isolated and characterized. In smooth muscle, inositol 1,4,5-trisphosphate (IP3) is believed to mobilize Ca2+ from internal stores and thereby modulate contraction. We describe the isolation of an IP3 receptor from smooth muscle. Bovine aorta smooth muscle microsomes were solubilized with 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate, and the IP3 receptor was purified by sucrose gradient centrifugation and column chromatography with heparin-agarose and wheat germ agglutinin-agarose. The purified receptor bound 2.7 +/- 0.18 nmol of IP3 per mg of protein with a Kd of 2.4 +/- 0.24 nM. That is, the purified receptor has been enriched about 1000-fold compared with the original microsomes, whereas the Kd for IP3 remains unchanged. The receptor is an oligomer of a single polypeptide with a Mr of 224,000 as determined by SDS/PAGE. Negative-staining electron microscopy reveals that the receptor is a large pinwheel-like structure having surface dimensions of approximately 250 X 250 A with fourfold symmetry. The IP3 receptor from smooth muscle is similar to the ryanodine receptor with regard to its large size and fourfold symmetry, albeit distinct with regard to appearance, protomer size, and ligand binding.
Targeting Platelet-Derived Growth Factor Receptor on Endothelial Cells of Multidrug-Resistant Prostate Cancer (2006)

Tumor-associated endothelial cells, rather than tumor cells themselves, appear to be the target for imatinib in prostate cancer bone metastasis.
Giving employers what they want. Successful CEOs read warning signs. (1993)

Corporate executives are becoming activists in challenging the fundamentals of the healthcare delivery system and in developing standards for selective contracting. The actions they take could drive many providers from the market.
An acoustic echo canceler with noise and echo reduction (2004)

An acoustic echo canceler, needed for hands-free telecommunications in videoconferencing, has been realized with sufficient performance for use in a quiet meeting room. However, demand has been increasing for the use of hands-free teleconferencing in an environment with ambient noise such as conference calls in a noisy office or in a running automobile. In response to such demands, this paper proposes an echo canceler with a capability of simultaneously suppressing stationary ambient noise superposed on the speech and also residual echo, which cannot be eliminated by conventional echo cancelers because it is buried in noise. In this paper, the noise reduction and echo reduction process, based on the short-time spectrum amplitude estimation, is first explained. Then the results of objective evaluation of a test-fabricated echo canceler are presented. The evaluation results confirm that the echo can be reduced by about 30 dB and the ambient noise by about 15 dB even in an environment with ambient noise, allowing satisfactory hands-free conference calling to be realized. © 2004 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 88(3): 21–31, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecjc.20123
Development of vegetable‐oil‐based polymers (2014)

ABSTRACT The utilization of renewable resources for the preparation of new materials is an alternative option for reducing the high demand of fossil feedstocks. Vegetable oils are potential bioresources that are renewable and abundantly available. Triglyceride‐based vegetable oils, such as soybean, jatropha, linseed, sunflower, palm, castor, nahar seed, and canola oil, are being considered as precursors in the production of polymers. In this article, we attempt to summarize advancements in processes and technologies for the synthesis of polymers from various kinds of vegetable oils. The advantages and disadvantages of these biobased polymers with respect to traditional monomer‐based ones are also highlighted. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40787.
The receptor like kinase at Rhg1-a/Rfs2 caused pleiotropic resistance to sudden death syndrome and soybean cyst nematode as a transgene by altering signaling responses (2012)

The inference that soybean has adapted part of an existing pathogen recognition and defense cascade (H.glycines; SCN and insect herbivory) to a new pathogen (F. virguliforme; SDS) has broad implications for crop improvement. Stable resistance to many pathogens might be achieved by manipulation the genes encoding a small number of pathogen recognition proteins.
Immunohistochemical Quantitation of Thymidylate Synthase Expression in Colorectal Cancer Metastases Predicts for Clinical Outcome to Fluorouracil-Based Chemotherapy (1999)

In this cohort of homogenously treated patients, intratumor TS content was a major predictor of clinical outcome. Immunohistochemical TS quantitation provides a convenient, low-cost technique for identifying patients unresponsive to TS inhibitors who may be candidates for alternative chemotherapy regimens.
A novel distributed genetic algorithm implementation with variable number of islands (2007)

Genetic algorithm (GA) has some inherent drawbacks which become apparent while trying to solve complex multimodal problems. They are slow and the efficiency depends on parameter values. Some methods were proposed for alleviating these problems. But they did not address all the drawbacks. In this work, we propose a new distributed implementation strategy named variable island GA (VIGA), where the number of islands vary. In VIGA, where the number of individuals in every island is 2, the parameter population size in an island is fixed. Other parameters like number of islands, crossover/mutation probabilities, also need not be set. As the generation progresses, islands are created or erased based on the convergence status of searching in each island. Experiments were done with different function optimization problems. For all experiments VIGA delivered better or at least as good results as obtained by other competitive algorithms, at the expense of less computation and communication costs.
Experimental Immunization with a Monoclonal Anti-Idiotope Antibody that Mimics the Neisseria gonorrhoeae Lipooligosaccharide Epitope 2C7 (1996)

An anti-idiotope monoclonal antibody (MAb), called CA1 (Ab2), was produced in mice against MAb 2C7, which recognizes a widely in vivo-expressed gonococcal lipooligosaccharide (LOS) epitope. Mice immunized with MAb CA1 initially had a 2.5-fold increase in IgG (12-fold after a booster) but no increase in IgM anti-LOS (Ab1') antibody. Control mice immunized with LOS had a 4.5-fold rise in IgG and 4-fold rise in IgM anti-LOS antibody. In rabbits, MAb CA1 elicited a 9-fold rise in IgG and a 3.3-fold rise in IgM anti-LOS (Ab1') antibody. Ab1' antibody bactericidal activity was 1-2 logs greater than that produced by immunization with LOS. Ab1' mediated complete human polymorphonuclear leukocyte phagocytosis of 2C7 epitope-positive (but not 2C7 epitope-negative) gonococci. MAb CA1 acts as a molecular surrogate (Ab2beta) for the nominal LOS antigen and may form the basis for vaccine candidates for human immunization against Neisseria gonorrhoeae.
Enhanced In Vivo Homing of Uncultured and Selectively Amplified Umbilical Cord Blood CD34+ Cells by Co-Transplantation with Cord Blood Derived Unrestricted Somatic Stem Cells. (2005)

Abstract Mesenchymal stem cells have been implicated as playing an important role in stem cell engraftment. A new pluripotent population of umbilical cord blood (UCB)-derived Unrestricted Somatic Stem Cells (USSCs), with intrinsic and directable potential to develop into mesodermal, endodermal and ectodermal fates, has recently been identified and characterized (1). In this study we evaluated the capacity of USSCs to influence the homing of UCB -derived CD34+ cells into the marrow and spleen of NOD/SCID mice. Cultured USSCs were co-transplanted with CFDA-labeled cord blood CD34+ cells into sublethally irradiated NOD/SCID mice. Femurs and spleens were harvested 16 hrs thereafter and the percentage of CD34+ cells determined by flow cytometry. USSCs induced a significant enhancement of CD34+ cell homing to both bone marrow and spleen (2.2 ± 0.3 and 2.4 ± 0.6 -fold, respectively; p&lt;0.05). Similar findings were obtained with frozen USSC samples that had been thawed prior to transplantation. The effect of USSCs was specific, as no homing enhancement could be observed by co-transplantation of CD34+ cells with lineage-positive UCB cells, which contain T, B and mature myelo-erythroid cells. Enhanced marrow homing by USSCs was unaltered by extensive culture passaging of the cells, with a similar degree of enhancement observed for both early (p5) and late (p10) passage USSCs (1.7 ± 0.1 and 1.9 ± 0.1 -fold, respectively). Enhanced homing was dose-dependent, detectable at USSC/CD34+ ratios of 1:1 and above. USSCs were also found to enhance the homing of day 14 cells harvested from cultures of selectively amplifiedTM, ex-vivo expanded UCB lineage-negative (lin-) cells. The relative proportion of homing CD34+ cells within the culture-expanded cell population, was unaffected by USSC co-transplantation. Our findings thus demonstrate that USSCs enhance the homing of UCB hematopoietic stem cells and suggest a clinical potential for these cells in facilitating engraftment under conditions of limiting cord blood stem cell numbers.
Rabies virus nucleoprotein as a carrier for foreign antigens (2004)

Rabies virus (RV) nucleoprotein (N) tightly encapsidates the genomic and antigenomic RNA of RV to form the viral ribonucleoprotein (RNP) complex. Antigens, such as N, presented in a highly organized structure are sufficient and even desirable to activate B cells to proliferate and produce antibodies. In addition to activating B cells to proliferate, it has been shown that RV N in the RNP complex induces potent T helper cell responses resulting in long-lasting and strong humoral immune responses against RV. The possibility to systematically incorporate foreign genes into the genome of RV and produce a recombinant virus allows us to examine whether the immunogenicity of foreign antigens can be enhanced by incorporation into the RV RNP structure. To test this hypothesis we constructed a recombinant RV expressing a RV N-GFP fusion protein. The chimeric N-GFP fusion protein was efficiently expressed and incorporated into RV RNP and virions. Moreover, the recombinant RNP induces a strong humoral immune response against GFP in mice. In contrast, mice inoculated with GFP alone or a combination of wild-type RV RNPs and GFP did not trigger any GFP-specific humoral responses using the same immunization schedule. These data indicate the usefulness of RV-based vectors as killed vaccines against other infectious diseases.
The Developmental Stage of Adult Human Stem Cell-Derived Retinal Pigment Epithelium Cells Influences Transplant Efficacy for Vision Rescue (2017)

Age-related macular degeneration (AMD) is a common cause of central visual loss in the elderly. Retinal pigment epithelial (RPE) cell loss occurs early in the course of AMD and RPE cell transplantation holds promise to slow disease progression. We report that subretinal transplantation of RPE stem cell (RPESC)-derived RPE cells (RPESC-RPE) preserved vision in a rat model of RPE cell dysfunction. Importantly, the stage of differentiation that RPESC-RPE acquired prior to transplantation influenced the efficacy of vision rescue. Whereas cells at all stages of differentiation tested rescued photoreceptor layer morphology, an intermediate stage of RPESC-RPE differentiation obtained after 4 weeks of culture was more consistent at vision rescue than progeny that were differentiated for 2 weeks or 8 weeks of culture. Our results indicate that the developmental stage of RPESC-RPE significantly influences the efficacy of RPE cell replacement, which affects the therapeutic application of these cells for AMD.
Learning to Optimize Tensor Programs (2018)

We introduce a learning-based framework to optimize tensor programs for deep learning workloads. Efficient implementations of tensor operators, such as matrix multiplication and high dimensional convolution are key enablers of effective deep learning systems. However, existing systems rely on manually optimized libraries such as cuDNN where only a narrow range of server class GPUs are well-supported. The reliance on hardware specific operator libraries limits the applicability of high-level graph optimizations and incurs significant engineering costs when deploying to new hardware targets. We use learning to remove this engineering burden. We learn domain specific statistical cost models to guide the search of tensor operator implementations over billions of possible program variants. We further accelerate the search by effective model transfer across workloads. Experimental results show that our framework delivers performance competitive with state-of-the-art hand-tuned libraries for low-power CPU, mobile GPU, and server-class GPU.
Silica gel supported sodium hydrogensulfate as a heterogenous catalyst for high yield synthesis of 2-arylbenzothiazoles (2006)

Department of Chemistry. J. N. T. University. Kukatpally. Hyderabad-500 072, India <em>E-mail </em>: drmacj@yahoo.ro.uk Fax: 91-40-23060056 <em>Manuscript received 10 March 2005, revised 26 August 2005, accepted 21 November 2005</em> Silica gel supported sodium bisulfate catalyzes efficiently the synthesis of 2-arylbenzothiazoles by the condensation of 2-aminothiophenol and aromatic aldehyde in refluxing acetonitrile to afford the corresponding 2-arylbenzothiazoles.