gebhart/patrepeval huggingface dataset:
Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Cα-binding protein rPICK1 (2001)

TIS21 is induced transiently by PMA and a number of extracellular stimuli. Yeast two-hybrid screening has identified three TIS21 interacting clones from a rat cDNA library [Lin, Gary, Yang, Clarke and Herschman (1996) J. Biol. Chem 271, 15034–15044]. The amino acid sequence deduced from clone 5A shows 96.9% identity with the murine PICK1, a protein kinase Cα (PKCα)-binding protein postulated to act as an intracellular receptor for PKC. A fusion protein of glutathione S-transferase and rPICK1 associates with the TIS21 translated in vitro, suggesting a direct physical interaction between these two proteins. TIS21 and rPICK1 are co-immunoprecipitated from NIH 3T3 cells overexpressing these two proteins. This indicates that the interaction also occurs in mammalian cells. Deletion of the PDZ domain at the N-terminus of rPICK1 abolishes its interaction with TIS21. A putative carboxylate-binding loop required for PICK1 to bind PKCα [Staudinger, Lu and Olson (1997) J. Biol. Chem 272, 32019–32024] is within this deleted region. Our results suggest a potential competition between TIS21 and PKC for binding to PICK1. We show that recombinant TIS21 is phosphorylated by PKC in vitro. The catalytic activity of PKC towards TIS21 is significantly decreased in the presence of rPICK1, whereas phosphorylation of histone by PKC is not affected. rPICK1 seems to modulate the phosphorylation of TIS21 through specific interactions between these two proteins. TIS21 might have a role in PKC-mediated extracellular signal transduction through its interaction with rPICK1.
GENERATION OF 3D BUILDING MODELS FROM COMMERCIAL IMAGE DATABASE THROUGH SAHDOW ANALYSIS (2010)

Many people use a commercial image database such as Google Earth Image map from the internet. We propose a method by volumetric shadow analysis for generation of 3D building models from the commercial image database. The proposed method can extract building heights and building footprints using volumetric shadows analysis from a single image. No external control points are required. Instead, the proposed method needs the directions of the sun and the camera is needed. As the commercial image database does not provide them, we estimated them by simple image measurements and a known height of one reference building. For experiments, images extracted from Google Earth were used. For performance analysis of our method, building heights extracted by our method were compared with building heights extracted by stereo IKONOS images as reference. The Root Mean Square Errors (RMSE) calculated from the comparison were under 2 m. The experiment result shows 3D building models can be effectively generated from the commercial image database by the proposed method.
Integrating Anatomy and Physiology for Behavior Modeling (1995)

. In producing realistic, animatable models of the human body, we see much to be gained from developing a functional anatomy that links the anatomical and physiological behavior of the body through fundamental causal principles. This paper describes our current Finite Element Method implementation of a simplified lung and chest cavity during normal quiet breathing and then disturbed by a simple pneumothorax. The lung model interacts with the model of the chest cavity through applied forces. The models are modular, and a second lung and more complex chest wall model can be added without disturbing the model of the other lung. During inhalation, a breathing force (corresponding to exertion of the diaphragm and chest wall muscles) is applied, causing the chest cavity to expand. When this force is removed (at the start of exhalation), the stretched lung recoils, applying pressure forces to the chest wall which cause the chest cavity to contract. To simulate a simple pneumothorax, the intra...
High performance transparent thin film transistors based on indium gallium zinc oxide as the channel material (2007)

The fabrication of high performance amorphous indium gallium zinc oxide (IGZO) transparent thin film transistors (TTFT) and their bias stress stability is presented. N-channel enhancement mode devices were fabricated with an extracted field effect mobility of ~ 11-15 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> V <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> s <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , on/off current ratios > 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> , subthreshold gate voltage swing of 0.20-0.25 V/decade, low off-state currents and good saturation. Low and tunable threshold voltages of 1-2 V were achieved. We conclude that a charge trapping mechanism at the semiconductor/dielectric interface is responsible for the threshold voltage shift after a gate bias stress. The threshold voltage is recovered when the bias is removed.
Sine-wave Current for Efficient and Safe In Vivo Gene Transfer (2007)

Recently, electro-gene transfer has become a powerful tool to enhance the efficiency of gene expression in different organs and particularly in muscle, which provides efficient secretion of therapeutic proteins into the circulation. However, its toxicity, owing to the high field strengths of conventional direct current (DC) square-waves, should be taken into account and should be minimized if electroporation is to be used routinely for the treatment of human diseases. In this study, we demonstrate that efficient in vivo gene transfer could be safely achieved using pulses of alternating current sine-waves (ACSWs) with a frequency of 60 Hz. Importantly, the field strength was decreased to as low as 20 V/cm and the efficiency of muscle gene transfer increased more than tenfold and showed less toxicity than with conventional DC square-wave pulses. Using ACSW pulses to transfer human clotting factor IX (hFIX) plasmid into muscle, we observed significant phenotypic correction in mice with hemophilia B.
Fast Intra Prediction Mode Decision by Adaptively Selecting Fewer Number of Modes (2007)

Enhanced Intra and Inter prediction techniques are the key factors to the success of H.264. There are a total of nine optional prediction modes for each 4 x 4 luma block. H.264 adapts Rate Distortion Optimization (RDO) technique to get high coding rate and visual quality. Because RDO is too much exhaustive, several attempts have been made to explore fast algorithms. The choice of intra prediction mode for each 4 x 4 block must be signaled to the decoder and this could potentially require a large number of bits. However, intra modes for neighbouring 4 x 4 blocks are often correlated. To take advantage of this correlation, predictive coding is used to signal 4 x 4 intra modes. But still large number of bits is required to signal nine intra prediction modes. We adaptively selected only five modes; selection of modes depends on the position of 4 x 4 block in the slice or frame. After experimental results we have come to know that the increase in the number of bits for encoding residual coefficients is approximately same as decrease in the number of bits required to signal intra prediction modes, providing same PSNR (peak signal to noise ratio). By using proposed technique, computational speed increased by ≈45% without significant performance degradation.
Applications of Fuzzy Logic to Artificial Colour Vision (1986)

Decision processing on colours demands something more than the exact colour science which has largely dominated the design of colour inspection systems until the present. The work to be described challenges the traditional view by the introduction of the concept of fuzziness to broaden the decision aspects in determining colour by artificial means. Here colours are regarded as fuzzy sets described by so called 'fuzzy membership functions', which are subsets to a universe of discourse (in this case a chromaticity space). Members of these subsets are neither wholly inclusive nor exclusive to the set itself, hence giving rise to fuzziness in the definition of a colour. In a typical application, fuzzy connectives are used to perform operations of union and intersection between membership functions so as to produce a resultant fuzzy set which is characteristic of several colours as described by a simple mathematical equation.
Slight and short-lasting increase of serum S-100B protein in extra-cranial trauma (2006)

Extra-cranial injury results in a mild elevation of serum S-100B protein that declines rapidly (1-3 days after injury).
Immunochemical identification of the <i>pssA</i> gene product as phosphatidylserine synthase I of Chinese hamster ovary cells (1996)

We have previously shown that a Chinese hamster ovary (CHO) cell mutant defective in phosphatidylserine synthase I recovers the enzyme activity on transfection with a pssA cDNA clone isolated from the parental CHO-K1. The resultant transfectant, CDT-1, exhibited about 20-fold higher specific activity of the enzyme in the membrane fraction than CHO-K1 cells. Polyclonal antibodies against two peptides of the predicted pssA product cross-reacted with a membrane protein having an apparent molecular mass of 42 kDa, which was overproduced in CDT-1 cells. By immunoprecipitation with the antibody, phosphatidylserine synthase I activity as well as the 42-kDa protein was eliminated from solubilized membrane proteins of CDT-1 cells. Both the enzyme activity and the 42-kDa protein of CHO-K1 cells were enriched in the mitochondria-associated membrane fraction and the microsome fraction, but neither was enriched in the mitochondria fraction or the cytosol fraction. These results suggest that the pssA gene encodes phosphatidylserine synthase I.
Design of Weak 1-D Bragg Grating Filters in SOI Waveguides Using Volume Holography Techniques (2014)

To answer the growing need for more versatile integrated spectral filters, we show that weak one-dimensional gratings can be designed towards any desired target spectrum. We follow a very straightforward design procedure to demonstrate the performance of these devices. Measurements and simulations show a very good correspondence with the target spectra. By analyzing the results, we also found that the design procedure can be refined by using simulated reflections, instead of relying on the calculated Fresnel reflections.
CO2-laser-induced deflagration of fuel/oxygen mixtures (1983)

Weakly focused pulsed-CO2-laser radiation has been examined as an ignition source for low-pressure (85–100 Torr), near-stoichiometric fuel/oxygen mixtures containing the following fuels: ethylene, methyl fluoride, methanol, ethanol, dimethyl ether, p-dioxane, n-propyl nitrate, and iso-propyl nitrate. The data analysis includes characterization of the spatially dependent ir absorption in the test cell, calculation of appropriate medium temperatures from the absorbed laser energy, and correlation of observed ignition delay times tig with the calculated temperatures. Effects of hydrodynamic motion on the pressure, density, and temperature profiles of the irradiated samples were modeled using a computer code for two-dimensional wave propagation. Code predictions are in accordance with experimental pressure-time histories obtained using a piezoelectric transducer. Minimum ignition temperatures ranged from 590 K for the iso-propyl nitrate/O2 system to 1645 K for CH3F/O2. The observed functional relationship between tig and temperature T was generally of the form ln tig =A/T+B, where A and B are constants. This relationship follows the form predicted by thermal and degenerate chain ignition theories, viz., ln tig =Eact/ RT+constant, where Eact corresponds to an overall activation energy. Using this relation, derived activation energies are 86, 57, 42, 47, ∼40, 13, and 12 kcal/mole for the CH3F/O2, CH3OCH3/O2, CH3OH/O2, C2H5OH/O2, C4H8O2/O2, n-propyl nitrate/O2, and iso-propyl nitrate/O2 mixtures, respectively. These results are in reasonable agreement with available data from shock-tube and hot air stream injection techniques. In contrast, an anomalous, threshold-like effect was observed for laser ignition of C2H4/O2. The applicability of ignition schemes of this type to time-resolved kinetic spectroscopic studies is briefly discussed.
Puzzled by realism: a response to Deichsel (2011)

No realist project in and about economics is close to completion. There are many open issues that remain to be addressed and resolved. Simon Deichsel (2011) has written a healthy challenge that should offer some useful inspiration to anyone interested in assessing and perhaps contributing to the realist projects. He argues against realism and in support of some sort of anti-realism. My response first deals with some conceptual issues regarding the very ideas of realism and anti-realism. I will then discuss the role of pragmatics in relation to truth. Finally, I will address the issue of justifying realism-Deichsel's title, after all, suggests his challenge is directed against what he calls the pragmatic justification of realism.
Experimental verification of novel method to reduce quantization lobes for phased array radar (2012)

The authors previously proposed a novel method to reduce quantization lobes, which occur due to the use of digital phase shifters in phased array antennas. This paper describes how we confirmed the method's validity through experiments. In the experiments, we applied the method to an imaging radar that has a phased array antenna with a one-bit digital phase shifter and so has a high average level of quantization lobes in the radiation pattern. In doing so, we found that a noise-like artefact, which appeared in the radar-image background due to the high average quantization-lobe level, was reduced respectively by 7.3 dB and 9.2 dB with integrating factors of two and four. These results were in good agreement with predicted results.
Synthesis and deblocking of cardanol‐ and anacardate‐blocked toluene diisocyanates (2004)

Abstract Methyl anacardate and secondary butyl anacardate were prepared from anacardic acid and corresponding alcohols and were used, in addition to cardanol, as blocking agents for 2,4‐toluene diisocyanate (TDI). Blocked diisocyanate adducts were characterized via nitrogen estimation, Fourier transform infrared spectroscopy, and proton nuclear magnetic resonance spectroscopy. The deblocking temperatures of the adducts were determined using an FTIR spectrophotometer in conjunction with the carbon dioxide evolution method. The gel times of hydroxyl‐terminated polybutadiene–TDI adducts also were determined. Deblocking temperature and gel time analyses revealed that cardanol‐blocked 2,4‐TDI deblocks at a lower temperature and at a higher rate compared with anacardate‐blocked adducts. In addition, it was found that the electron‐withdrawing ester group reduces the deblocking temperature of the adduct only when it is in solvated form. All adducts were waxy solids that were found to be soluble in polyether polyol, polyester polyol, and polyhydrocarbon polyols. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 4047–4055, 2004
Analytical expression for signal propagation delay of off-chip interconnection for SIP application (2007)

A new analytical expression is propossed for the calculation of the delay time of off-chip pin-to-pin interconnection. This includes all the line and the load parameters for CMOS based circuits. The classical on-chip analytical formulations available in the literature have been reviewed. Spice simulations are applied to compare the accuracy of the proposed expressions. Measurement results have been used for the determination of the accuracy of the spice line model.
Real-time person counting by propagating networks flows (2011)

In this paper we present a system that tracks multiple persons by detection in real-time. We introduce a measure for similarity of detections which segments significant information from background clutter by using statistical information obtained during the learning phase of the detector. In order to track multiple persons we map the detections into flow networks utilizing this measure. A continuous real-time processing of video streams is accomplished by analyzing only small chunks of detections consecutively using different networks. By propagating the result of one network into the subsequent one a temporal consistent association is achieved. The system was evaluated using a standard video sequence containing a crowded scene and an own dataset with very long sequences. The results demonstrate that the system performs comparable to other systems while meeting real-time requirements.
Efectividad de una intervención educativa en la reducción de accidentes corto punzantes en el personal de enfermería (2010)

Introduccion: Los accidentes de trabajo corto punzantes son una potencial fuente de problemas debido a los perjuicios que pueden causar. Los sanitarios son el grupo de trabajadores que soportan un mayor riesgo. Si se estudian por separado las diferentes categorias, se puede comprobar que la mas afectada es la de las enfermeras, lo que sugiere la planificacion y ejecucion de actividades para lograr la disminucion. Se disena un proyecto de investigacion con el que se pretende concienciar a estos profesionales de la importancia de adoptar procedimientos seguros que minimicen estos percances.
Metodologia: Estudio cuasi experimental antes despues con grupos de comparacion, mediante la medicion de percances por puncion accidental, realizacion de una actividad formativa programada dirigida al total de enfermeras del centro y una nueva medicion de los accidentes tras finalizar el ciclo de sesiones. 
Resultados: Durante 2003-2004-2005 se informaron 436 accidentes. De ellos, 354 (81.6%) fueron percutaneos (P) y 80 (18.4%) por contacto (C). En el segundo trienio, los accidentes fueron 468 (419, 89.5% P y 49, 10.4%, C). Solo se hallaron diferencias estadisticamente significativas en los dos periodos entre el total de accidentes y sus diferentes tipos y en los accidentes por contacto en los tecnicos sanitarios (p<0.05), asi como en los accidentes totales y por puncion en los medicos (p<0.001). 
Discusion-conclusiones: Ademas de los datos obtenidos, el grupo ha facilitado informes de asesoramiento a la Direccion del centro que, junto con otras acciones, han colaborado la adquisicion de material de seguridad. Hay un primer descenso en todos los grupos en 2006, con ligero repunte de los E en 2007, sin duda debido a la menor infradeclaracion gracias a la informacion suministrada.
Conclusion principal: Se recomienda el uso generalizado de material de seguridad, porque contribuyen al descenso de accidentes de alto riesgo biologico.
Teaching a Machine to Feel Postoperative Pain: Combining High-Dimensional Clinical Data with Machine Learning Algorithms to Forecast Acute Postoperative Pain (2015)

Machine learning algorithms, when combined with complex and heterogeneous data from electronic medical record systems, can forecast acute postoperative pain outcomes with accuracies similar to methods that rely only on variables specifically collected for pain outcome prediction.
Synthesis and Tryptic Hydrolysis of p-Guanidinophenyl Esters Derived from Amino Acids and Peptides. (1996)

A facile synthetic method for p-guanidinophenyl esters derived from a variety of amino acids and peptides, including D-amino acids, is presented. The kinetic behavior of trypsin towards these synthetic esters, inverse substrates, was analyzed. The spatial requirement of the enzyme active site for catalytic efficiency is discussed based on the steric characteristics of the substrates.
Liposomes Decorated with Apo2L/TRAIL Overcome Chemoresistance of Human Hematologic Tumor Cells (2013)

Human Apo2-ligand/TRAIL is a member of the TNF cytokine superfamily capable of inducing apoptosis on tumor cells while sparing normal cells. Besides its antitumor activity, Apo2L/TRAIL is also implicated in immune regulation. Apo2L/TRAIL is stored inside activated T cells in cytoplasmic multivesicular bodies and is physiologically released to the extracellular medium inserted in the internal membrane vesicles, known as exosomes. In this study we have generated artificial lipid vesicles coated with bioactive Apo2L/TRAIL, which resemble natural exosomes, to analyze their apoptosis-inducing ability on cell lines from hematological tumors. We have tethered Apo2L/TRAIL to lipid vesicles by using a novel Ni2+-(N-5-amino-1-carboxylpentyl)-iminodiacetic acid, NTA)-containing liposomal system. This lipidic framework (LUVs-Apo2L/TRAIL) greatly improves Apo2L/TRAIL activity, decreasing by around 14-fold the LC50 on the T-cell leukemia Jurkat. This increase in bioactivity correlated with the greater ability of LUVs-Apo2L/TRAIL to induce caspase-3 activation and is probably due to the increase in local concentration of Apo2L/TRAIL, improving its receptor cross-linking efficiency. More important, liposome-bound Apo2L/TRAIL overcame the resistance to soluble recombinant Apo2L/TRAIL exhibited by tumor cell mutants overexpressing Bcl-xL or by a Bax and Bak-defective Jurkat cell mutant (Jurkat-shBak) and are also effective against other hematologic tumor cells. Jurkat-Bcl-xL and Jurkat-shBak cells are resistant to most chemotherapeutic drugs currently used in cancer treatment, and their sensitivity to LUVs-Apo2L/TRAIL could have potential clinical applications.
Retroviral Delivery of Noggin Inhibits the Formation of Heterotopic Ossification Induced by BMP-4, Demineralized Bone Matrix, and Trauma in an Animal Model (2004)

Gene therapy to deliver Noggin may become a powerful method to inhibit heterotopic ossification in targeted areas of the body.
Cloudets: Cloud-based cognition for large streaming data (2015)

Big data cognition has become a dominant problem in interactive visual analytics for event detection and response, metereology, cosmology, and large smart city applications including traffic monitoring and management, search and rescue operations, crowd management and logistics. The main problems are mainly due to big data volume and velocity and, in some cases, variety in both dimension and type. A practical approach to understanding and viewing big data features is through streaming operations. Streaming allows for both volume and velocity characteristics of big data, and often, for variety as well. However, performing analytics at interactive rates is currently an open challenge in most big data applications. Cloud computing platforms provide practical support and leverage to solving some of the big data and visual analytics problems, especially when dealing with the volume and velocity characteristics of current data generation. In order to interact with streaming data patterns in an elastic cloud environment, we present a new elastic framework for big data visual analytics in the cloud, the Cloudet. The Cloudet is a self-adaptive cloud-based platform that treats both data and compute nodes as elastic objects. The main objective is to readily achieve the scalability and elasticity of cloud computing platforms in order to process large streaming data and adapt to potential interactions between data stream features. Our main contributions include a robust cloud-based framework, the Cloudet, which can flexibly process the streaming data and applications to illustrate the setup and operations of this framework. The framework includes a cloud profile manager that attempts to optimize the cloudet parameters in order to achieve expressivity, scalability, reliability, and the proper aggregation of the data streams into several density maps for the purpose of dynamic visualization of data features.