gebhart/patrepeval huggingface dataset:
Urine protein 1: a sex-dependent marker of tubular or glomerular dysfunction. (1989)

Journal Article Urine protein 1: a sex-dependent marker of tubular or glomerular dysfunction. Get access A M Bernard, A M Bernard Unité de Toxicologie Industrielle et Médecine du Travail, Université Catholique de Louvain, Brussels, Belgium Search for other works by this author on: Oxford Academic Google Scholar R R Lauwerys, R R Lauwerys Unité de Toxicologie Industrielle et Médecine du Travail, Université Catholique de Louvain, Brussels, Belgium Search for other works by this author on: Oxford Academic Google Scholar A Noël, A Noël Unité de Toxicologie Industrielle et Médecine du Travail, Université Catholique de Louvain, Brussels, Belgium Search for other works by this author on: Oxford Academic Google Scholar B Vandeleene, B Vandeleene Unité de Toxicologie Industrielle et Médecine du Travail, Université Catholique de Louvain, Brussels, Belgium Search for other works by this author on: Oxford Academic Google Scholar A Lambert A Lambert Unité de Toxicologie Industrielle et Médecine du Travail, Université Catholique de Louvain, Brussels, Belgium Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 35, Issue 10, 1 October 1989, Pages 2141–2142, https://doi.org/10.1093/clinchem/35.10.2141 Published: 01 October 1989
Short wavelength optical anisotropy in <inline-formula><math display="inline" overflow="scroll"><msub><mi>CaF</mi><mrow><mn>2</mn></mrow></msub></math></inline-formula> caused by exciton dispersion (2003)

Based on exact symmetry considerations one can show that a cubic system is always optically isotropic. Nevertheless even a perfectly cubic crystal such as CaF2 can show small optical anisotropy when interacting with light. Resolving this seeming contradiction leads to a phenomenon called spatial dispersion, which is an enhancement of optical anisotropy. While the initial tiny anisotropy is caused by the symmetry breaking of light, the enhancement that makes the effect observable is provided by the vicinity of a strong absorption. In semiconductors such an absorption is mainly given by the band gap but in an ionic crystal such as CaF2 the bound electron-hole pair, a deep excitonic two-particle bound state, is an additional strong absorption causing response functions to diverge as (ω−ω0)−1 in its vicinity, where ω0 is the bound state energy. We show that the exciton dispersion is able to explain in all details the optical anisotropy observed in CaF2 including the spatial-dispersion-induced birefringence, the so-called "intrinsic birefringence." As opposed to normal birefringence, the effect in CaF2 does not show up at large wavelengths and has seven optical axes instead of one.
Micromagnetic susceptometer (1980)

A variable temperature (4.2 K to 300 K) micromagnetic susceptometer has been designed to maximize sensitivity to the magnetic flux produced by small samples. The susceptometer is based upon a superconductive flux sensor which measures the magnetic flux through a set of coils due to a sample magnetized in a uniform field. A minimum measurable volume susceptibility of 7.5 ×10−8 (emu) for a 1 microgram sample of curium has been achieved giving an increase in sensitivity of two orders of magnitude over Faraday devices designed for microgram metallic samples.
A hybrd neural network for optimal TDMA transmission scheduling in packet radio networks (2006)

In this paper we propose a hybrid method to solve the broadcast scheduling problem in packet radio networks. In the first stage, we use a backtracking sequential coloring algorithm to obtain a minimal TDMA frame length and the corresponding transmission assignments. In the second stage, we employ the noisy chaotic neural network to find the maximum node transmission based on the results obtained in the previous stage. Simulation results show that this hybrid method outperforms previous approaches, such as mean field annealing, a hybrid of the Hopfield neural network and genetic algorithms, the sequential vertex coloring algorithm, and the gradual neural network.
Fuzzy modelling and simulation for aggregate production planning (2003)

The market demands and financial constraints in medium- to long-term production planning are often subject to uncertainties. As an extension of the author's previous paper, this paper focuses on a formulation and simulation analysis for multi-product aggregate production-planning problems with fuzzy demands and fuzzy capacities. The fuzzy production–inventory balance equation is formulated as a soft equation and can be interpreted as the possibility level of meeting the market demands, which is more meaningful and accepted by the practitioner than the previous one. With this interpretation, a fuzzy multi-product aggregate production-planning model is transformed into a parametric programming model. A simulation of a practical instance is conducted to illustrate the model and demonstrate the performance and effect of various parameters on the optimal aggregate production plan. The proposed formulation and simulation analysis can help the decision-maker make a reasonable and preferred aggregate plan to guarantee feasibility of the downstream family disaggregation plans.
Organomagnesium and Organozinc Chemistry (2013)

This chapter contains sections titled: Introduction Organomagnesium Reagents Organozinc Reagents
Hormonal Regulation of Testicular Luteinizing Hormone and Prolactin Receptors (1981)

The effects of gonadotropic stimulation on testicular LH and PRL receptors were examined in the absence and presence of elevated serum PRL levels. In adult male rats, the administration of ovine LH (oLH) caused an increase in both PRL and LH receptors within 40–120 min. This initial rise in testicular receptors was followed by the transient loss and recovery of PRL sites and a more prolonged loss of LH receptors. In contrast, the administration of bovine PRL or the elevation of circulating PRL levels during metoclopramide infusion caused no change in the lactogenic sites. A significant positive effect of increased serum PRL levels on testicular LH receptors was observed during metoclopramide infusion, but this did not prevent the loss of LH receptors caused by the administration of oLH. Similarly, prior treatment with bovine PRL failed to prevent the LH-induced loss of testicular LH receptors. These findings demonstrate that PRL and LH receptors exhibit concomitant but distinct forms of regulation during Leydig cell stimulation by oLH. Testicular receptor sites for both LH and PRL undergo a common process of increased availability during the early phase of Leydig cell activation by gonadotropins. This transient increase in both binding sites is followed by a subsequent period of depletion that is short-lived for the PRL sites and prolonged for the LH receptors. The long term action of PRL on the maintenance of testicular LH receptors does not influence the acute increase and subsequent loss of sites that follows gonadotropic stimulation of the Leydig cells. (Endocrinology108: 1607, 1981)
Generation of a cholesterol‐independent, non‐GS NS0 cell line through chemical treatment and application for high titer antibody production (2012)

NS0 cells require exogenous cholesterol for growth. The non-glutamine synthetase (GS) cholesterol-dependent NS0 host was treated with 5-azacytidine (5azaC), a demethylation drug, and adapted to grow in cholesterol-free, chemically defined medium. Within 7 weeks, a stable, cholesterol-independent NS0 host (NS0.CF) was obtained. The new NS0.CF host, as well as the original cholesterol auxotroph host, was transfected with the same mAb expression plasmid, and the top producing clone from both hosts were compared side-by-side in the enhanced platform fed-batch cultures using chemically defined media. The NS0.CF derived clone significantly out-performed the cholesterol-dependent clone, with titer reaching 4.5 g/L versus 3.0 g/L, respectively, mainly due to higher specific productivity, while key product quality attributes remained comparable. This work demonstrated an effective and rapid approach to generate a cholesterol-independent NS0 host, and its application in recombinant protein production.
Extracorporeal Irradiation of Blood and Lymph in Animals (1965)

DESPITE the intensive efforts of many investigators throughout the world only modest and inconstant improvements have been gained in the homotransplantation of tissues and the control of leukemia. The chemotherapeutic and radiotherapeutic maneuvers that aid in the control of immunologic processes and leukemic-cell proliferation also have serious widespread destructive effects upon normal tissues. Not infrequently the sequelae of the destructive effects of these agents upon the bone marrow or the bowel, or both, result in the death of the patient. It has long been believed and now proved that lymphocytic, immunologically competent cells1 are ceaselessly migrating from extravascular sites of . . .
Intraoperative hippocampal electrocorticography to predict the extent of hippocampal resection in temporal lobe epilepsy surgery (2000)

Intraoperative hippocampal ECoG can predict how much hippocampus should be removed to maximize seizure-free outcome, allowing for sparing of possibly functionally important hippocampus.
Functional characterization and expression of endothelin receptors in rat carotid artery: involvement of nitric oxide, a vasodilator prostanoid and the opening of K<sup>+</sup> channels in ET<sub>B</sub>‐induced relaxation (2005)

We aimed to functionally characterize endothelin (ET) receptors in the rat carotid artery. mRNA and protein expressions of both ETA and ETB receptors, evaluated by reverse transcription-polymerase chain reaction (RT-PCR) and Western immunoblotting, were detected in carotid segments. Immunohistochemical assays showed that ETB receptors are expressed in the endothelium and smooth muscle cells, while ETA receptors are expressed only in the smooth muscle cells. In endothelium-denuded vessels, levels of ETB receptor mRNA were reduced. Vascular reactivity experiments, using standard muscle bath procedures, showed that ET-1 induces contraction in endothelium-intact and -denuded carotid rings in a concentration-dependent manner. Endothelial removal enhanced ET-1-induced contraction. BQ123 and BQ788, selective antagonists for ETA and ETB receptors, respectively, produced concentration-dependent rightward displacements of the ET-1 concentration-response curves. IRL1620, a selective agonist for ETB receptors, induced a slight vasoconstriction that was abolished by BQ788, but not affected by BQ123. IRL1620-induced contraction was augmented after endothelium removal. ET-1 concentration dependently relaxed phenylephrine-precontracted rings with intact endothelium. The relaxation was augmented in the presence of BQ123, reduced in the presence of BQ788 and completely abolished after endothelium removal. IRL1620 induced vasorelaxation that was abolished by BQ788 and endothelium removal, but not affected by BQ123. Preincubation of intact rings with N(G)-nitro-L-arginine methyl ester (L-NAME), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), indomethacin or tetraethylammonium (TEA) reduced IRL1620-induced relaxation. The combination of L-NAME, indomethacin and TEA completely abolished IRL1620-induced relaxation while sulfaphenazole did not affect this response. 4-aminopyridine (4-AP), but not apamin, glibenclamide or charybdotoxin, reduced IRL1620-induced relaxation. The major finding of this work is that it firstly demonstrated functionally the existence of both ETA and ETB vasoconstrictor receptors located on the smooth muscle of rat carotid arteries and endothelial ETB receptors that mediated vasorelaxation via NO-cGMP pathway, vasodilator cyclooxygenase product(s) and the activation of voltage-dependent K+ channels.
Learning to Estimate Pose by Watching Videos (2017)

In this paper we propose a technique for obtaining coarse pose estimation of humans in an image that does not require any manual supervision. While a general unsupervised technique would fail to estimate human pose, we suggest that sufficient information about coarse pose can be obtained by observing human motion in multiple frames. Specifically, we consider obtaining surrogate supervision through videos as a means for obtaining motion based grouping cues. We supplement the method using a basic object detector that detects persons. With just these components we obtain a rough estimate of the human pose. With these samples for training, we train a fully convolutional neural network (FCNN)[20] to obtain accurate dense blob based pose estimation. We show that the results obtained are close to the ground-truth and to the results obtained using a fully supervised convolutional pose estimation method [31] as evaluated on a challenging dataset [15]. This is further validated by evaluating the obtained poses using a pose based action recognition method [5]. In this setting we outperform the results as obtained using the baseline method that uses a fully supervised pose estimation algorithm and is competitive with a new baseline created using convolutional pose estimation with full supervision.
Synthesis and properties of fluorinated polyamideimides with high solubility (2004)

Abstract A series of fluorinated polyamideimides (PAIs) were synthesized by the direct polycondensation of a novel diimide‐diacid, 1,4‐bis(trimellitimido‐2‐trifluoromethylphenoxy) benzene (BTTFB), with aromatic diamines by using triphenyl phosphite (TPP) and pyridine as condensation agents in a medium consisting of N ‐methyl‐2‐pyrrolidone (NMP) and CaCl 2 . Most of the resulting polymers showed an amorphous nature. All the fluorinated PAIs were readily soluble in a variety of organic solvents such as NMP, N , N ‐dimethyl acetamide, dimethylformamide, and dimethyl sulfoxide and could even be dissolved in less polar solvents such as THF and m ‐cresol. The PAIs had inherent viscosities of 0.77–0.93 dL/g, depending on the diamines. All the soluble PAIs afforded transparent, flexible, and tough films that exhibited excellent thermal stability, good mechanical properties, and low moisture absorption. The glass transition temperatures of these PAIs ranged from 244 to 272°C and the 5% weight loss temperatures were >525°C in nitrogen. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 95: 321–327, 2005
Surface Concentration of a Styrene-Dimethylsiloxane Block Copolymer in Mixtures with Polystyrene (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface Concentration of a Styrene-Dimethylsiloxane Block Copolymer in Mixtures with PolystyreneG. L. Gaines Jr. and G. W. BenderCite this: Macromolecules 1972, 5, 1, 82–86Publication Date (Print):January 1, 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://doi.org/10.1021/ma60025a019RIGHTS & PERMISSIONSArticle Views125Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (524 KB) Get e-Alerts Get e-Alerts
Epigenetic Signatures of Cigarette Smoking (2016)

Cigarette smoking has a broad impact on genome-wide methylation that, at many loci, persists many years after smoking cessation. Many of the differentially methylated genes were novel genes with respect to biological effects of smoking and might represent therapeutic targets for prevention or treatment of tobacco-related diseases. Methylation at these sites could also serve as sensitive and stable biomarkers of lifetime exposure to tobacco smoke.
IBM System Storage Ds8000 Series: Architecture and Implementation (2007)

This book will help you plan, install, and configure the IBM System Storage DS8000 Series. This publication discusses the architecture and components of the DS8000, and it provides useful information for those who will manage the DS8000. It includes hints and tips derived from users experiences for efficient installation and use. The DS8000 Series considerably extends the high performance and virtualization capabilities of its predecessors and is available in several Turbo models with IBM POWER5+ dual two-way or dual four-way processor complex implementations, as well as a Storage System LPAR capable model. All models use a switched Fibre Channel design that enables larger growth capacities, plus reliability and service characteristics appropriate for the most demanding requirements. The DS8000 increased power and extended connectivity make it suitable for environments with multiple servers, both for open systems and System z. The DS8000 Turbo models also feature: point-in-time and Remote Mirror and Copy functions for business continuance solutions; 500 GB FATA drives for capacities up to 320 TB and 512 TB; the 4 Gb Fibre Channel /FICON host adapter connectivity option. Other enhancements such as Storage Pool Striping and Dynamic Volume Expansion are discussed in this edition.
An Evidence-Based Systematic Review of Elderberry and Elderflower (<i>Sambucus nigra</i>) by the Natural Standard Research Collaboration (2014)

An evidence-based systematic review of elderberry and elderflower (Sambucus nigra) by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated, reproducible grading rationale. This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
Development of Peptidomimetics Targeting IAPs (2006)

Inhibitor of apoptosis proteins (IAPs) such as XIAP subvert apoptosis by binding and inhibiting caspases. Because occupation of the XIAP BIR3 peptide binding pocket by Smac abolishes the XIAP-caspase 9 interaction, it is a proapoptotic event of great therapeutic interest. An assay for pocket binding was developed based on the displacement of Smac 7-mer from BIR3. Through the physical and biochemical analysis of a variety of peptides, we have determined the minimum sequence required for inhibition of the Smac-BIR3 interaction and detailed the dimensions and topology of the BIR3 peptide binding pocket. This work describes the structure-activity relationship (SAR) for peptide inhibitors of Smac-IAP binding.
A Convenient Catalyst for Aqueous and Protein Suzuki−Miyaura Cross-Coupling (2009)

A phosphine-free palladium catalyst for aqueous Suzuki-Miyaura cross-coupling is presented. The catalyst is active enough to mediate hindered, ortho-substituted biaryl couplings but mild enough for use on peptides and proteins. The Suzuki-Miyaura couplings on protein substrates are the first to proceed in useful conversions. Notably, hydrophobic aryl and vinyl groups can be transferred to the protein surface without the aid of organic solvent since the aryl- and vinylboronic acids used in the coupling are water-soluble as borate salts. The convenience and activity of this catalyst prompts use in both general synthesis and bioconjugation.
Full Bicycle Dynamic Model for Interactive Bicycle Simulator (2005)

Abstract An interactive bicycle simulator with six degrees of freedom motion system could bring the rider a very realistic riding feeling. An important component of the simulator is the full bicycle dynamic model that simulated the two-wheeled bicycle dynamics. It consists of two slightly coupled submodels: The stability submodel and the vibration submodel. The stability submodel solves the stability of the bicycle under rider’s active maneuvers and the vibration submodel evaluates the vibration response of the bicycle due to uneven road surface. The model was validated by several experiments and successfully applied to the interactive bicycle simulator.
Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis (2003)

To test the hypothesis that asbestos-mediated cell injury is mediated through an oxidant-dependent mitochondrial pathway, isolated mesothelial cells were examined for mitochondrial DNA damage as determined by quantitative PCR. Mitochondrial DNA damage occurred at fourfold lower concentrations of crocidolite asbestos compared with concentrations required for nuclear DNA damage. DNA damage by asbestos was preceded by oxidant stress as shown by confocal scanning laser microscopy using MitoTracker Green FM and the oxidant probe Redox Sensor Red CC-1. These events were associated with dose-related decreases in steady-state mRNA levels of cytochrome c oxidase, subunit 3 (COIII), and NADH dehydrogenase 5. Subsequently, dose-dependent decreases in formazan production, an indication of mitochondrial dysfunction, increased mRNA expression of pro- and antiapoptotic genes, and increased numbers of apoptotic cells were observed in asbestos-exposed mesothelial cells. The possible contribution of mitochondrial-derived pathways to asbestos-induced apoptosis was confirmed by its significant reduction after pretreatment of cells with a caspase-9 inhibitor. Apoptosis was decreased in the presence of catalase. Last, use of HeLa cells transfected with a mitochondrial transport sequence targeting the human DNA repair enzyme 8-oxoguanine DNA glycosylase to mitochondria demonstrated that asbestos-induced apoptosis was ameliorated with increased cell survival. Studies collectively indicate that mitochondria are initial targets of asbestos-induced DNA damage and apoptosis via an oxidant-related mechanism.
Hedgehogs tryst with the cell cycle (2002)

Hedgehog proteins play an essential role during pattern formation in animal development and, increasingly, much of our appreciation of their modes of action is emanating from studies of their signalling mechanisms at the cellular level. Recent work has provided insights into how Hedgehog controls the cell cycle in a variety of circumstances. The data suggest that this influence may be direct and operates through interaction of the signalling pathway with cell cycle regulators at multiple points within the cell cycle. These new findings have profound implications in the context of clinical conditions - especially cancers - that arise from de-regulated cell proliferation in response to aberrant Hedgehog signalling activity.