gebhart/patrepeval huggingface dataset:
Stereolithographic Bone Scaffold Design Parameters: Osteogenic Differentiation and Signal Expression (2010)

Scaffold design parameters including porosity, pore size, interconnectivity, and mechanical properties have a significant influence on osteogenic signal expression and differentiation. This review evaluates the influence of each of these parameters and then discusses the ability of stereolithography (SLA) to be used to tailor scaffold design to optimize these parameters. Scaffold porosity and pore size affect osteogenic cell signaling and ultimately in vivo bone tissue growth. Alternatively, scaffold interconnectivity has a great influence on in vivo bone growth but little work has been done to determine if interconnectivity causes changes in signaling levels. Osteogenic cell signaling could be also influenced by scaffold mechanical properties such as scaffold rigidity and dynamic relationships between the cells and their extracellular matrix. With knowledge of the effects of these parameters on cellular functions, an optimal tissue engineering scaffold can be designed, but a proper technology must exist to produce this design to specification in a repeatable manner. SLA has been shown to be capable of fabricating scaffolds with controlled architecture and micrometer-level resolution. Surgical implantation of these scaffolds is a promising clinical treatment for successful bone regeneration. By applying knowledge of how scaffold parameters influence osteogenic cell signaling to scaffold manufacturing using SLA, tissue engineers may move closer to creating the optimal tissue engineering scaffold.
Treatment with silybin‐vitamin E‐phospholipid complex in patients with hepatitis C infection (2008)

The aim of this study was to evaluate the hepatoprotective and anti-inflammatory effects of silybin-phospholipids and vitamin E complex (SPV complex), by determining cytokine patterns and various markers of liver disease. Forty Caucasian patients with chronic HCV infection were recruited and divided into two groups: 30 were treated with SPV complex for 3 months, while the other 10 did not receive any treatment. Ten other subjects without HCV infection but with staeatosic diagnosis were recruited and treated with SPV complex. Biochemical and hepatic principal parameters were investigated at 0 (T0) and 3 months (T3). The group of HCV patients treated showed an improvement trend of hepatic indecises and viral load, and had a significant and persistent reduction of ALT (P = 0.02) and AST serum level (P = 0.01). In this group cytokines showed a statistically significant increase of IL-2 (P = 0.03) and IL-6 were significantly reduced (P = 0.02) at T0 and T3. After the treatment the group of hepatic steatosics showed a significant decrease in ALT (P = 0.02), AST (0.008), gammaGT (0.004) alkaline phosphatase (0.05), total cholesterol (P = 0.03), fasting glucose (P = 0.008), insulinemia (0.0006), HOMA value (0.002) and C-reactive protein (CRP; 0.04). There was a significant reduction of IFN-gamma, TNF-alpha, and IL-6 (P = 0.02, 0.05 and 0.04, respectively). The data suggest that the SPV complex exerts hepatoprotective, anti-inflammatory and antifibrotic effects. This new compound may therefore be useful in clinical practice in patients with chronic hepatitis C who cannot undergo conventional antiviral therapy.
Progression to cancer in Barrett's esophagus is associated with genomic instability. (1989)

Barrett's esophagus is a condition in which metaplastic columnar epithelium replaces squamous esophageal epithelium as a consequence of chronic gastroesophageal reflux. Patients with this condition are at increased risk for the development of adenocarcinoma. To better understand the progression to adenocarcinoma in this disease, we studied abnormalities in DNA content of epithelial cells in Barrett's esophagus. Using flow cytometry, we examined the spatial distribution of abnormal nuclear DNA contents (aneuploidy) in the esophagi of 14 patients with Barrett's adenocarcinoma. Multiple (2 to 14) populations of aneuploid cells were seen in 12 of the 14 cases. Some early carcinomas appeared to be associated with a single aneuploid population of cells. Surrounding dysplastic epithelium often contained multiple, different overlapping aneuploid populations. These data suggest that neoplastic progression in Barret's esophagus is associated with a process of genomic instability which leads to evolution of multiple aneuploid populations, with the ultimate development of a clone of cells capable of malignant invasion. Thus, detection of multiple aneuploid populations of cells in Barrett's esophagus may indicate a high risk of cancer. Barrett's esophagus provides a unique and readily accessible model for the study of neoplastic progression in human epithelial malignancy.
Optimal capacitance assignment of switched-capacitor biquads (1995)

An algorithm is presented for the optimal capacitance assignment of conventional switched-capacitor biquads. It maximizes the dynamic range and minimizes the total capacitance simultaneously, with results presented in analytical forms. This is made possible by the development of a canonical representation of second-order transfer functions in the z-domain, which gives simple relations among three sets of parameters: (1) the pole-and zero-frequencies, and pole- and zero-Q's of the s-domain prototype; (2) the key parameters of the bilinear-transformed z-domain transfer function; and (3) the capacitance ratios of the final switched-capacitor realization. Analytical results are derived and compared with those from using existing assignment techniques. This shows a reduction of 12% in total capacitance for some biquads. An extension of the algorithm to very large time-constant biquads is also discussed; the improvement is even larger for these circuits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
AmpC  -lactamases: what do we need to know for the future? (2003)

2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Spacecraft collision avoidance challenge: Design and results of a machine learning competition (2021)

Abstract Spacecraft collision avoidance procedures have become an essential part of satellite operations. Complex and constantly updated estimates of the collision risk between orbiting objects inform various operators who can then plan risk mitigation measures. Such measures can be aided by the development of suitable machine learning (ML) models that predict, for example, the evolution of the collision risk over time. In October 2019, in an attempt to study this opportunity, the European Space Agency released a large curated dataset containing information about close approach events in the form of conjunction data messages (CDMs), which was collected from 2015 to 2019. This dataset was used in the Spacecraft Collision Avoidance Challenge, which was an ML competition where participants had to build models to predict the final collision risk between orbiting objects. This paper describes the design and results of the competition and discusses the challenges and lessons learned when applying ML methods to this problem domain.
Sequencing and expression of the 6'-N-acetyltransferase gene of transposon Tn1331 from Klebsiella pneumoniae (1988)

Plasmid-mediated amikacin resistance in Klebsiella pneumoniae resides on a 1.5-kilobase BamHI fragment which is part of the Tn3-related multiresistance transposon Tn1331. In this work, we present the complete nucleotide sequence of the amikacin resistance gene and the neighboring sequences. Maxicell experiments detected only one polypeptide of 23 kilodaltons, the product of one of the open reading frames identified as ORF I. Comparison of the complete sequence with that of Tn3 indicated that 396 base pairs located just upstream from ORF I are identical to a region between the end of the tnpR gene and the first six amino acids of the beta-lactamase transcript. Sequences which may act as hot spots for recombination were identified. One was located just after amino acid 6 of beta-lactamase, and the other was located at the end of the amikacin resistance gene.
Antiemetic therapy options for chemotherapy-induced nausea and vomiting in breast cancer patients (2011)

Chemotherapy-induced nausea and vomiting (CINV) continues to be one of the most distressing side effects of chemotherapy in breast cancer patients, which can result in poor compliance to therapy that may, in turn, affect overall survival. The extent of CINV is dependent on the emetogenic potential of the individual cytotoxic agents or regimens employed as well as certain patient factors. Advances in our understanding in the pathophysiology of CINV and the identification of risk factors have enabled the utilization of appropriate antiemetic regimens to improve the control of CINV. Most of the chemotherapy regimens used in this patient population are considered to be moderately emetogenic; 60%-90% of chemotherapeutic regimens used in breast cancer patients cause nausea and vomiting, amongst which regimens doxorubicin-cyclophosphamide (AC) combination is commonly regarded as of relatively higher emetogenicity. Currently, corticosteroids, 5-hydroxytryptamine 3 (5-HT3) receptor antagonists, and neurokinin 1 (NK-1) receptor antagonists are the three classes of antiemetic agents with the highest therapeutic index, which have been supported by data from large-scale randomized clinical trials. Treatment guidelines enable physicians to integrate the latest research data into their clinical practices. This review focuses on the three classes of antiemetic therapy options for CINV in breast cancer patients, as well as their safety and tolerability profiles. Recommendations from major guidelines/consensus including from the Multinational Association for Supportive Care in Cancer/European Society of Medical Oncology (MASCC/ESMO), the American Society of Clinical Oncology (ASCO), and the US National Comprehensive Cancer Network (NCCN), are also discussed. With the correct use of antiemetic regimens, chemotherapy-induced vomiting could be prevented in the majority of patients. However, chemotherapy-induced nausea remains an important symptom and a challenge for physicians to manage.
Modeling the turn-off of IGBT's in hard- and soft-switching applications (1997)

The turn-off of IGBTs in hard- and soft-switching converters is analyzed using nonquasi-static analysis. It is shown that while the turn-off current waveform for hard-switching is governed solely by the device for a particular value of on-state current and bus voltage, turn-off current waveform for soft-switching is strongly dependent on device-circuit interactions, so that a trade-off between turn-off loss and switching time can be made using external circuit elements. Models are developed to explain IGBT turn-off for both hard- and soft-switching conditions. Hard-switching considers both inductive and resistive loads. Calculated results are validated by comparison with results of measurements and two-dimensional (2-D) numerical simulations.
Fluorinated Distyrylbenzene Chromophores:  Effect of Fluorine Regiochemistry on Molecular Properties and Solid-State Organization (1999)

A series of fluorinated distyrylbenzene (DSB) derivatives were synthesized and studied in order to probe the effect of fluorine substitution on molecular properties and on the arrangement of molecules in the solid state. Reaction of 1,4-diiodobenzene with 4-fluorostyrene or pentafluorostyrene in the presence of Pd(OAc)2 gives trans-trans-bis(4-fluorostyryl)benzene (2Ft) and trans-trans-1,4-bis(pentafluorostyryl)benzene (10Ft), respectively. Bis(2,5-difluorostyryl)benzene (4Ft) was prepared by the reaction of 2,5-difluorobenzaldehyde with p-xylylenebis-(triphenylphosphonium bromide) in the presence of LiOEt in EtOH. Coupling of 1,4-dibromo-2,5-difluorobenzene with styrene, 4-fluorostyrene, or pentafluorostyrene using Pd(OAc)2 gives 1,4-bis(styryl)-2,5-difluorobenzene (2Fc), 1,4-bis(4-fluorostyryl)-2,5-difluorobenzene (2Fc2Ft), and 1,4-bis(pentafluorostyryl)-2,5-difluorobenzene (2Fc10Ft), respectively. Absorption spectroscopy shows that DSB, 2Ft, 2Fc, 2Fc2Ft, 4Ft, 10Ft, and 2Fc10Ft have a λmax at approximately 350 nm. Addition of dimethylaniline to hexane solutions results in exciplex emission with λmax ranging from 458 to 514 nm, depending on fluorine regiochemistry. Cyclic voltammetry shows that, as the fluorine load increases, the reduction of the DSB framework becomes more facile. It is also shown that the regiochemistry of substitution makes an impact on the inductive ability of fluorine to facilitate reduction. The lattice properties of 2Fc, 2Fc2Ft, 4Ft, 10Ft, and 2Fc10Ft were determined by X-ray diffraction experiments. Two structural motifs emerge from these studies. One is the tendency of the DSB framework to stack cofacially and form vertical “columns” within the crystal. The second motif is the alignment of these “columns” to maximize C−H···F electrostatic registry.
Magnetic resonance studies of the oxidation and reduction of organic molecules by ionizing radiations (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnetic resonance studies of the oxidation and reduction of organic molecules by ionizing radiationsHarold C. Box, Harold G. Freund, Kenneth T. Lilga, and Edwin E. BudzinskiCite this: J. Phys. Chem. 1970, 74, 1, 40–52Publication Date (Print):January 1, 1970Publication History Published online1 May 2002Published inissue 1 January 1970https://pubs.acs.org/doi/10.1021/j100696a007https://doi.org/10.1021/j100696a007research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Purification and Partial Characterization of Maize (<i>Zea mays</i> L.) β-Glucosidase (1992)

Maize (Zea mays L.) beta-glucosidase (beta-d-glucoside glucohydrolase, EC 3.2.1.21) was extracted from the coleoptiles of 5- to 6-day-old maize seedlings with 50 millimolar sodium acetate, pH 5.0. The pH of the extract was adjusted to 4.6, and most of the contaminating proteins were cryoprecipitated at 0 degrees C for 24 hours. The pH 4.6 supernatant from cryoprecipitation was further fractionated by chromatography on an Accell CM column using a 4.8 to 6.8 pH gradient of 50 millimolar sodium acetate, which yielded the enzyme in two homogeneous, chromatographically different fractions. Purified enzyme was characterized with respect to subunit molecular weight, isoelectric point, amino acid composition, NH(2)-terminal amino acid sequence, pH and temperature optima, thermostability, and activity and stability in the presence of selected reducing agents, metal ions, and alkylating agents. The purified enzyme has an estimated subunit molecular mass of 60 kilodaltons, isoelectric point at pH 5.2, and pH and temperature optima at 5.8 and 50 degrees C, respectively. The amino acid composition data indicate that the enzyme is rich in Glx and Asx, the sum of which approaches 25%. The sequence of the first 20 amino acids in the N-terminal region was H(2)N-Ser-Ala-Arg-Val-Gly-Ser-Gln-Asn-Gly-Val-Gln-Met-Leu-Ser-Pro-(Ser?) -Glu-Ile-Pro-Gln, and it shows no significant similarity to other proteins with known sequence. The enzyme is extremely stable at 0 to 4 degrees C up to 1 year but loses activity completely at and above 55 degrees C in 10 minutes. Likewise, the enzyme is stable in the presence of or after treatment with 500 millimolar 2-mercaptoethanol, and it is totally inactivated at 2000 millimolar 2-mercaptoethanol. Such metal ions as Hg(2+) and Ag(+) reversibly inhibit the enzyme at micromolar concentrations, and inhibition could be completely overcome by adding 2-mercaptoethanol at molar excess of the inhibitory metal ion. The alkylating agents iodoacetic acid and iodoacetamide irreversibly inactivate the enzyme and such inactivation is accelerated in the presence of urea.
Highly Stretchable and Sensitive Unidirectional Strain Sensor via Laser Carbonization (2015)

In this paper, we present a simple and low-cost technique for fabricating highly stretchable (up to 100% strain) and sensitive (gauge factor of up to 20 000) strain sensors. Our technique is based on transfer and embedment of carbonized patterns created through selective laser pyrolization of thermoset polymers, such as polyimide, into elastomeric substrates (e.g., PDMS or Ecoflex). Embedded carbonized materials are composed of partially aligned graphene and carbon nanotube (CNT) particles and show a sharp directional anisotropy, which enables the fabrication of extremely robust, highly stretchable, and unidirectional strain sensors. Raman spectrum of pyrolized carbon regions reveal that under optimal laser settings, one can obtain highly porous carbon nano/microparticles with sheet resistances as low as 60 Ω/□. Using this technique, we fabricate an instrumented latex glove capable of measuring finger motion in real-time.
Effect of Boron Addition on the Thermal, Degradation, and Cytocompatibility Properties of Phosphate-Based Glasses (2013)

In this study eight different phosphate-based glass compositions were prepared by melt-quenching: four in the (P2O5)45-(CaO)16-(Na2O)15-x -(MgO)24-(B2O3) x system and four in the system (P2O5)50-(CaO)16-(Na2O)10-x -(MgO)24-(B2O3) x , where x = 0,1, 5 and 10 mol%. The effect of B2O3 addition on the thermal properties, density, molar volume, dissolution rates, and cytocompatibility were studied for both glass systems. Addition of B2O3 increased the glass transition (T(g)), crystallisation (T(c)), melting (T(m)), Liquidus (T(L)) and dilatometric softening (T(d)) temperature and molar volume (V(m)). The thermal expansion coefficient (α) and density (ρ) were seen to decrease. An assessment of the thermal stability of the glasses was made in terms of their processing window (crystallisation onset, T(c,ons) minus glass transition temperature, T(g)), and an increase in the processing window was observed with increasing B2O3 content. Degradation studies of the glasses revealed that the rates decreased with increasing B2O3 content and a decrease in degradation rates was also observed as the P2O5 content reduced from 50 to 45 mol%. MG63 osteoblast-like cells cultured in direct contact with the glass samples for 14 days revealed comparative data to the positive control for the cell metabolic activity, proliferation, ALP activity, and morphology for glasses containing up to 5 mol% of B2O3.
Numerical modeling of intensity and phase noise in semiconductor lasers (2001)

A self-consistent numerical approach is demonstrated to analyze intensity and phase noise in semiconductor lasers. The approach takes into account the intrinsic fluctuations of the photon number, carrier number, and phase. A new systematic technique is proposed to generate the Langevin noise sources that derive the laser rate equations keeping their cross-correlations satisfied. The simulation is applied to AlGaAs lasers operating in a single mode. The time-varying profiles of the fluctuating photon and carrier numbers and the instantaneous shift of the oscillating frequency are presented. Statistical analysis of the intensity and phase fluctuations is given. The frequency spectra of intensity and phase noise are calculated with help of the fast Fourier transform. The importance of taking into account the carrier number noise source and its cross-correlation with the noise source on the phase is examined by comparing our results with those by conventional methods.
Certain Biominerals in Leaves Function as Light Scatterers (2012)

Cystoliths are amorphous calcium carbonate bodies that form in the leaves of some plant families. Cystoliths are regularly distributed in the epidermis and protrude into the photosynthetic tissue, the mesophyll. The photosynthetic pigments generate a steep light gradient in the leaf. Under most illumination regimes the outer mesophyll is light saturated, thus the photosynthetic apparatus is kinetically unable to use the excess light for photochemistry. Here we use micro-scale modulated fluorometry to demonstrate that light scattered by the cystoliths is distributed from the photosynthetically inefficient upper tissue to the efficient, but light deprived, lower tissue. The results prove that the presence of light scatterers reduces the steep light gradient, thus enabling the leaf to use the incoming light flux more efficiently. MicroCT and electron microscopy confirm that the spatial distribution of the minerals is compatible with their optical function. During the study we encountered large calcium oxalate druses in the same anatomical location as the cystoliths. These druses proved to have similar light scattering functions as the cystoliths. This study shows that certain minerals in the leaves of different plants distribute the light flux more evenly inside the leaf.
Topical and intravenous administration of trefoil factors protect the gastric mucosa from ethanol‐induced injury in the rat (2000)

Intravenously infused hTFF2 and pTFF2 protect the gastric mucosa from ethanol-induced damage in the anaesthetized rat. In addition, topical application of trefoil factors also was effective at protecting the gastric mucosa from injury at doses lower than previously reported.
New liquid membrane electrode for the determination of ephedrine, epinephrine, and norepinephrine (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew liquid membrane electrode for the determination of ephedrine, epinephrine, and norepinephrineSaad S. M. Hassan and G. A. RechnitzCite this: Anal. Chem. 1986, 58, 6, 1052–1054Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/ac00297a015https://doi.org/10.1021/ac00297a015research-articleACS PublicationsRequest reuse permissionsArticle Views171Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts