gebhart/patrepeval huggingface dataset:
Mitochondrial permeability transition pore as a target for cardioprotection in the human heart (2005)

After an episode of myocardial ischemia, opening of the mitochondrial permeability transition pore (mPTP), at the onset of reperfusion, is a critical determinant of myocyte death. We investigated the role of the mPTP as a target for cardioprotection in the human heart. We subjected human atrial tissue, harvested from patients undergoing cardiac surgery, to a period of lethal hypoxia and investigated the effect of suppressing mPTP opening at the onset of reoxygenation. We found that suppressing mPTP opening at the onset of reoxygenation with known mPTP inhibitors cyclosporin A (CsA, 0.2 micromol/l) and sanglifehrin A (SfA, 1.0 micromol/l) 1) improved recovery of baseline contractile function from 29.4 +/- 2.0% under control conditions to 48.7 +/- 2.2% with CsA and 46.1 +/- 2.3% with SfA (P < 0.01) and 2) improved cell survival from 62.8 +/- 5.3% under hypoxic control conditions to 91.4 +/- 4.1% with CsA and 87.2 +/- 6.2% with SfA (P < 0.001). Furthermore, with a cell model in which oxidative stress was used to induce mPTP opening in human atrial myocytes, we demonstrated directly that CsA and SfA mediated their cardioprotective effects by inhibiting mPTP opening, as evidenced by an extension in the time required to induce mPTP opening from 116 +/- 8 s under control conditions to 189 +/- 10 s with CsA and 183 +/- 12 s with SfA (P < 0.01). We report that suppressing mPTP opening at the onset of reoxygenation protects human myocardium against lethal hypoxia-reoxygenation injury. This suggests that, in the human heart, the mPTP is a viable target for cardioprotection.
Two-Stage Aerosol Synthesis of Titanium Nitride TiN and Titanium Oxynitride TiO<i><sub>x</sub></i>N<i><sub>y</sub></i> Nanopowders of Spherical Particle Morphology (2006)

The two-stage aerosol-assisted synthesis technique was first used to prepare titanium containing raw aerosol powders with spherical particle morphology from aqueous and methanol solutions of selected oxygen-bearing titanium precursors and from neat titanium(IV) i-propoxide. The aerosol powders were subsequently pyrolyzed under ammonia at 1000, 1100, and 1200 °C, giving, in some favorable cases, compositions ranging from titanium oxynitride TiOxNy to titanium nitride TiN with average crystallite sizes of 32−38 nm and a residual oxygen content in the latter below 2 wt %. The intermediate and final products were characterized by SEM, XRD, FT-IR, and XPS analytical methods. For selected materials, oxygen content, helium density, and BET surface area were also determined.
A Region of the <i>Herpesvirus saimiri</i> Genome Required for Oncogenicity (1985)

Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.
The relationship between serum endotoxin level and intestinal flora in cirrhotic patients (2005)

Feces from 16 healthy adults and 33 patients with cirrhosis ( 20 patients in Child -Pugh B and 13 in Child -Pugh C) were cultured aerobically and anaerobically by using quantitative study. Serum endotoxin concentrations were determined with limulus ameobocyte lystate. Bifidobacterium and bacteroides were significantly decreased in patients with corrhosis compared with healthy controls, while escherichia coli and fusobacterium were markedly increased (P<0.01). The number of escherichia coli and intestinal coccus increased markedly in Child-Pugh C inpatients with cirrhosis than in Child-Pugh B (P<0.05) while the number of bifidobacterium significantly decreased (P<0.05). The number of fusobacterium and bacteroides has no significant difference in two group. Serum endotoxin level increased significantly in patients with cirrhosis compared with healthy controls (P<0.01), and increased markedly in Child-Pugh C compared with in Child-Pugh B (P<0.05); the number of escherichia coli increased gradually in control group, Child-Pugh B and Child-Pugh C, while the number of bifidobacterium decreased markedly (compared with control group (P<0.01), compared with Child-Pugh B P<0.05). Both were parallel to the higher endotoxin level with a close correlation (r=0.6, P<0.01; r=-0.4, P<0.05). In cirrhotic patients, there is an imbalance in the intestinal flora. Representative anaerobic bacteria bifidobacteria decrease and aerobic bacteria escherichia coli and intestinal coccus increased. The overgrowth of aerobic bacteria escherichia coli and intestinal coccus as well as the decrease in anaerobic bacteria bifidobacterium may play an important role in the development of enterogenic endotoxemia in cirrhosis.
Hardware task scheduling optimizations for reconfigurable computing (2008)

Reconfigurable computers (RC) can provide significant performance improvement for domain applications. However, wide acceptance of todaypsilas RCs among domain scientist is hindered by the complexity of design tools and the required hardware design experience. Recent developments in hardware/software co-design methodologies for these systems provide the ease of use, but they are not comparable in performance to manual co-design. This paper aims at improving the overall performance of hardware tasks assigned to FPGA. Particularly the analysis of inter-task communication as well as data dependencies among tasks are used to reduce the number of configurations and to minimize the communication overhead and task processing time. This work leverages algorithms developed in the RC and reconfigurable hardware (RH) domains to address efficient use of hardware resources to propose two algorithms, weight-based scheduling (WBS) and highest priority first-next fit (HPF-NF). However, traditional resource based scheduling alone is not sufficient to reduce the performance bottleneck, therefore a comprehensive algorithm is necessary. The reduced data movement scheduling (RDMS) algorithm is proposed to address dependency analysis and inter-task communication optimizations. Simulation shows that compared to WBS and HPF-NF, RDMS is able to reduce the amount of FPGA configurations to schedule random generated graphs with heavy weight nodes by 30% and 11% respectively. Additionally, the proof-of-concept implementation of a complex 13-node example task graph on the SGI RC100 reconfigurable computer shows that RDMS is not only able to trim down the amount of necessary configurations from 6 to 4 but also to reduce communication overhead by 48% and the hardware processing time by 33%.
A comparison of valve resistance, the continuity equation, and the Gorlin formula against directly observed orifice area in bioprosthetic valves in the mitral position: an in vitro study. (1996)

In conclusion, no single formula adequately predicted all observed orifice areas although resistance and the Gorlin formula gave useful predictions after empirical correction.
A monoclonal antibody-derived antigen of<i>Babesia divergens</i>: characterization and investigation of its ability to protect gerbils against virulent homologous challenge (1989)

A Babesia divergens merozoite antigen was purified by affinity chromatography using a monoclonal antibody. Silver staining of SDS-PAGE gels revealed 2 bands of Mr 50-60 kDa and Mr 24-29. It is proposed that the Mr 24-29 kDa band represents the native protein and that it is complexed, perhaps as a dimer or perhaps to host protein to give the Mr 50-60 kDa band. Peptide analysis of the antigen followed by Western blotting with the monoclonal antibody revealed only an Mr 20-24 kDa band. After affinity purification the antigen was precipitated with acetone and inoculated subcutaneously, together with complete Freund's adjuvant, into gerbils. Two inoculations were given 3 weeks apart, after which the immunized animals and a group of control animals were challenged with 5 x 10(7) parasitized red cells from a virulent microaerophilus stationary phase (MASP) culture of an homologous strain of B. divergens. Parasitaemias rose rapidly in control animals and all were dead by the fifth day. Two of the vaccinated animals survived the challenge. Parasitaemias in the remaining two rose slowly but both animals succumbed on the seventh day. Western blotting of merozoites and of the purified antigen, using sera from the surviving animals showed strong reactivity with the Mr 24-29 kDa band.
The Politics of Opposition: China’s Moderates at the Political Consultative Conference of 1946 (2014)

When analyzed in the context of the first Political Consultative Conference (PCC), a series of multiparty negotiations held in January of 1946, the theory of third party incompetence begins to break down. A more in-depth analysis of the Chinese third force reveals that their liberal philosophies were backed up with practical plans, and primary source documents from the PCC reveal that Chinese liberals in fact possessed a detailed and comprehensive strategy for China’s future.
Construction of a Double Recombinant Adenovirus Vector Expressing a Heterodimeric Cytokine: <i>In Vitro</i> and <i>In Vivo</i> Production of Biologically Active Interleukin-12 (1996)

Interleukin-12 (IL-12) is a heterodimeric cytokine that plays an important role in the development of cellular immunity. Clinical applications for this lymphokine include resolution of infectious disease, cancer immunotherapy, and boosting cellular immunity in AIDS patients. When using IL-12 and other cytokines therapeutically, an approach designed to obtain localized cytokine expression would be beneficial, because this could reduce the problem of systemic toxicity. As a means of developing a suitable delivery vehicle for IL-12, we have produced double-recombinant adenovirus vectors containing the p35 subunit cDNA of murine IL-12 in early region 1 of adenovirus type 5 and the cDNA for p40 in early region 3 (AdmIL-12). Cell lines infected with AdmIL-12 produced up to 42,000 units of IL-12/10(6) cells per 24 hr. Biological activity of the virally expressed product was demonstrated in vitro through its ability to induce proliferation of phytohemagglutinin (PHA)-stimulated lymphoblasts and to stimulate natural killer (NK) activity in naive splenocytes. Mice injected intraperitoneally with these vectors displayed serum IL-12 levels that increased proportionately with the amount of virus administered. IL-12 production in vivo caused a dose-dependent increase in splenic and lung NK cell activity. This work represents the first demonstration of a double-recombinant adenovirus vector expressing a functional heterodimeric protein. The results of these studies support the use of AdmIL-12 as an efficient delivery vehicle for IL-12, and direct studies of its ability to modulate cellular immunity in vivo are currently underway.
[Use of modern technologies in the diagnosis and combined treatment of brain stem tumors]. (2003)

The latest technologies, introduced into neurosurgery during the last 2 decades of the 20th century, ensured progress in the diagnostics and treatment of brainstem tumors--pathologies that remain until now a most complicated problem in neurooncology. The modern diagnostic tools comprising profound dynamic neurological and neurophysiological examinations (AVP, EEG) visualization techniques (CT, MRT with contrasting, MRT, spectroscopy, PET) provide for detecting not only the initial signs of stem tumors and their sizes but also their topographic interaction with the stem structures; it, in its turn, opens up a possibility to choose between the combined surgical treatment and the radiotherapy or chemotherapy alone. The clinical course, diagnosis and combined treatment of 333 children and adults with tumors bordering on the brainstem are analyzed within the case study.
Iron assimilation storage in prokaryotes (1992)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Influence of carbon towards improved lithium storage properties of Li2MnSiO4 cathodes (2011)

Superior lithium storage in Li2MnSiO4 cathodes was observed by altering carbon content during the formulation of electrodes. Initially, Li2MnSiO4 was prepared by a conventional solid-state reaction at 900 °C under Ar flow with a fixed amount of adipic acid, which acts as a gelating agent during synthesis. The phase formation was confirmed through powder X-ray diffraction measurements. Scanning electron microscope pictures indicate the particulate morphology of synthesized Li2MnSiO4 particles. Various compositions of electrodes were formulated using the conducting carbon (ketjen black) from 3 to 11 mg along with active material. All the fabricated electrodes were cycled in a Li/Li2MnSiO4 cell configuration to evaluate its lithium storage performance at 0.05 C rate. Among the electrodes, 42% carbon in the composite electrode exhibited a very stable discharge behaviour ∼140 mA h g−1 for 40 cycles at room temperature. Such storage performance was ascribed to the improved electronic conductivity of Li2MnSiO4 electrodes by incorporating carbon. This improvement was supported by electrochemical impedance spectroscopy measurements. Rate performance studies were also conducted and presented in the manuscript.
Estimation of Angular Velocity and Acceleration from Shaft-Encoder Measurements (1998)

This paper suggests a Kalman-filter approach to the estimation of angular velocity and acceleration from (quantized) shaft-encoder measurements. Finite-difference estimates deteriorate as sampling rates are increased. For small sampling periods, we show that the filtering problem is the dual of the cheap control problem, and we jus tify the use of all-integrator models. We investigate Kalman filtering with constant sampling rate, and also with measurements triggered by encoder pulses. Simulation and experimental results are given.
Update on the Burkholderia cepacia complex (2005)

Significant advances in our understanding of the Burkholderia cepacia complex serve as a critical foundation for further efforts that ultimately will enable better infection control and the development of novel therapeutics to treat Burkholderia cepacia complex infection in persons with cystic fibrosis.
The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease (2015)

Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function. NRG-1/ErbB signaling is involved in a multitude of cardiac processes ranging from myocardial and cardiac conduction system development to angiogenic support of cardiomyocytes, to cardioprotective effects upon injury. Numerous studies of NRG-1 employ a variety of platforms, including in vitro assays, animal models, and human clinical trials, with equally varying and, sometimes, contradictory outcomes. NRG-1 has the potential to be used as a therapeutic tool in stem cell therapies, tissue engineering applications, and clinical diagnostics and treatment. This review presents a concise summary of the growing body of literature to highlight the temporally persistent significance of NRG-1/ErbB signaling throughout development, homeostasis, and disease in the heart, specifically in cardiomyocytes.
Haemopoietic growth factors (1997)

Haemopoietic growth factors are involved in the production of the various blood cells from progenitors in the bone marrow, making them useful in a range of clinical situations. The genes for several of them have been cloned and their production engineered by recombinant technology, making them widely available. Myeloid growth factors are used to support patients in the aftermath of chemotherapy and bone marrow transplantation and have potential application in the treatment of infectious diseases. Erythropoietin is widely used for patients with anaemia due to failure of marrow production, having established its effectiveness in chronic renal failure. Thrombopoietin has recently been described and may provide a means to alleviate thrombocytopenia. Current indications and areas of recent reappraisal are addressed in this review.
Single Polarizer Liquid Crystal Display Mode with Fast Response (2011)

We propose a single polarizer liquid crystal display (LCD) with a fast response that was designed using a polarization-dependent microlens array fabricated by the planarization of a curved lens surface with a liquid crystalline polymer. The single polarizer LCD is operated by the polarization-dependent focusing properties of a microlens consisting of a circular stop-mask and complementary open mask. Fast response can be obtained by the planarized lens surface because distortions associated with applied electric fields and LC alignments observed in conventional curved lenses are eliminated.
Cues to Deception in Social Media Communications (2014)

With the increasing reliance on social media as a dominant communication medium for current news and personal communications, communicators are capable of executing deception with relative ease. While past-related research has investigated written deception in traditional forms of computer mediated communication (e.g. email), we are interested determining if those same indicators hold in social media-like communication and if new, social-media specific linguistic cues to deception exist. Our contribution is two-fold: 1) we present results on human subjects experimentation to confirm existing and new linguistic cues to deception; 2) we present results on classifying deception from training machine learning classifiers using our best features to achieve an average 90% accuracy in cross fold validation.
Leveraging Collection Structure in Information Retrieval With Applications to Search in Conversational Social Media (2011)

Social media collections are becoming increasingly important in the everyday life of Internet users. Recent statistics show that sites hosting social media and community-generated content account for five of the top ten most visited websites in the United States [4], are visited regularly by a broad cross-section of Internet users [61, 67, 115] and host an enormous quantity of information [119, 48, 9]. The increasing importance and size of these collections requires that information retrieval systems pay special attention to these collections, and in particular pay attention to those aspects of social media collections that set them apart from the general web. Social media collections are interesting and challenging from the perspective of information retrieval systems. These collections are dynamic, with content being constantly added, removed and modified. These collections are time-sensitive, with the most recently added content often viewed as the most significant. These collections are richly structured, with authorship information, often threading structure and higher-level topical classifications. Although this type of collection structure is frequently critical for comprehension, it is rarely exploited in retrieval algorithms. This thesis investigates the hypothesis that we can improve retrieval performance in these collections by leveraging this type of structure. To evaluate this hypothesis, we present an exploration of search in several social media collections: blogs and online forums. We demonstrate the utility of leveraging collection structure in three different retrieval tasks: blog post search, blog feed search, and forum thread search. The techniques explored throughout these experiments include evaluating the representation granularity of collections of documents, and methods to incorporate content an author has written throughout the collection. Our results show that, although the retrieval tasks and techniques to leverage this type of collection structure are varied, in many cases substantial and significant retrieval quality improvements can be realized by leveraging this collection structure.
Feasibility of using intermediate x‐ray energies for highly conformal extracranial radiotherapy (2014)

The authors showed the feasibility of using flattening filter free 2 MV x-rays for extracranial treatments as evidenced by equivalent or superior dosimetry compared to 6 MV plans using the same inverse noncoplanar intensity modulated planning method.
Experimental Urolithiasis VIII: Furadantin in Treatment of Experimental Proteus Infection with Stone Formation (1954)

No AccessJournal of Urology1 Aug 1954Experimental Urolithiasis VIII: Furadantin in Treatment of Experimental Proteus Infection with Stone Formation C.W. Vebmeulen, and R. Goetz C.W. VebmeulenC.W. Vebmeulen Present address: Department of Surgery, University of Chicago, Chicago, Ill. More articles by this author , and R. GoetzR. Goetz More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)67549-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1954 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 72Issue 2August 1954Page: 96-101 Advertisement Copyright & Permissions© 1954 by The American Urological Association Education and Research, Inc.MetricsAuthor Information C.W. Vebmeulen Present address: Department of Surgery, University of Chicago, Chicago, Ill. More articles by this author R. Goetz More articles by this author Expand All Advertisement Loading ...
Anticancer drugs : reactive metabolism and drug interactions (1994)

Part 1 Metabolism and reactions of alkylating agents, P.B. Farmer: nitrogen mustard (mechlorethamine) prednismustine estramustine phosphate azo-mustards aniline mustard aziridinyl benzoquinones hexitol derivatives. Part 2 Metabolism and pharmacokinetic behaviour of cyclophosphamide and related oxazaphosphorines, N.E. Sladek: rationale for synthesis pharmacokinetics mechanism of cytotoxic action modulation of cyclophosphamide metabolism and the therapeutic consequences. Part 3 Metabolism of triazine anticancer agents, M. D'Incalci: metabolism and pharmacokinetics in different animal species drug interactions. Part 4 The metabolism of triazene antitumor drugs, M.D. Threadgill and A. Gescher: oxidative metabolism of 1-aryl-3, 3-dialkyltriazenes at the alkyl groups the role of metabolism in the mechanisms of toxicity, mutagenicity and carcinogenicity of triazenes. Part 5 The metabolism and mode of action of 2-chloroethylnitrosoureas, D.J. Reed: historical background metabolism animal studies CNCC metabolism the future. Part 6 Metabolism of the hydrazine anti-cancer agent, procarbazine, J.M. Erickson et al: antitumor activity toxicity factors modulating anticancer activity. Part 7 Chemical reactions occurring between metal-containing antineoplastic drugs and biological molecules, C.L. Litterst: metallocene. Part 8 Metabolism and reactions of quinoid anticancer agents, G. Powis: simple quinoids mitomycins streptonigrins. Part 9 Bleomycin hydrolase and tumor resistance to bleomycin, S.M. Sebti and J.S. Lazo. Part 10 Metabolic basis for the chemosensitization to anticancer drug action by nitroimidazoles, F.Y.F. Lee and P. Workman: metabolic basis of chemosensitization. Part 11 Effects of cancer disease on the metabolism of anticancer agents, S. Garratini et al: clinical studies. Part 12 Effects of anticancer drugs on drug metabolism, J. Aarbakke and L. Slordal: interactions by anticancer drugs.