gebhart/patrepeval huggingface dataset:
Long‐term effect of omega‐3 fatty acid supplementation in active rheumatoid arthritis (1994)

Daily supplementation with 2.6 gm of omega 3 results in significant clinical benefit and may reduce the need for concomitant antirheumatic medication.
Comparison of Ensemble Methods for Real Estate Appraisal (2018)

Real estate appraisal is necessary for a range of endeavours, including property insurance, investment analysis, taxation and sales listing. Along with prospective buyers and sellers, estimating the prices of real estates can benefit investors as well. This paper makes a comparative analysis of four ensemble methods, viz. Bootstrap Aggregating, Random Forest, Gradient Boosting and Extreme Gradient Boosting for real estate appraisal. The comparison is based on estimating real estate prices in Mumbai. The data for this study was obtained by web scraping from the real estate website 99acres. The collected data was utilized for training and testing the above-mentioned ensemble models and comparing their performances. Grid search was used for fine-tuning the hyperparameters of the learning models. Also, preprocessing techniques such as dimensionality reduction and one-hot encoding were used for improving the accuracy of the models. Analysis of the results shows that using ensemble methods for estimating real estate prices is a realistic prospect.
Molecular mechanisms of drug resistance (1990)

Research Article| December 01 1990 Molecular mechanisms of drug resistance J D Hayes; J D Hayes 1*University Department of Clinical Chemistry, Royal Infirmary, Edinburgh EH3 9YW, Scotland2†Imperial Cancer Research Fund, Molecular Pharmacology Group, University Department of Biochemistry, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar C R Wolf C R Wolf 1*University Department of Clinical Chemistry, Royal Infirmary, Edinburgh EH3 9YW, Scotland3†Imperial Cancer Research Fund, Molecular Pharmacology Group, University Department of Biochemistry, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8728 Print ISSN: 0264-6021 © 1990 London: The Biochemical Society1990 Biochem J (1990) 272 (2): 281–295. https://doi.org/10.1042/bj2720281 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation J D Hayes, C R Wolf; Molecular mechanisms of drug resistance. Biochem J 1 December 1990; 272 (2): 281–295. doi: https://doi.org/10.1042/bj2720281 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1990 London: The Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Influence of output waveguide on mode quality factor in semiconductor microlasers with an equilateral triangle resonator (2000)

Semiconductor microlasers with an equilateral triangle resonator (ETR) and an output waveguide are proposed and analyzed by the finite-difference time-domain technique and the Padé approximation. The numerical results show that microlasers with an output waveguide still have a high-quality factor (Q factor) and are suitable to realize directional emission. For the ETR with a 0.46-μm-width opening in one of the vertices connected to the output waveguide, we have the Q factor of 1.5×103 and 2.5×102 for the TM fundamental mode at the wavelength of 1.55 μm, as the side length of the ETR is 5 and 3 μm. The simulated intensity distributions are presented for the fundamental mode in the ETR with a side length of 3 μm and an opening of 0.23 μm.
Conformal Mapping of a 3D Face Representation onto a 2D Image for CNN Based Face Recognition (2018)

Fitting 3D Morphable Face Models (3DMM) to a 2D face image allows the separation of face shape from skin texture, as well as correction for face expression. However, the recovered 3D face representation is not readily amenable to processing by convolutional neural networks (CNN). We propose a conformal mapping from a 3D mesh to a 2D image, which makes these machine learning tools accessible by 3D face data. Experiments with a CNN based face recognition system designed using the proposed representation have been carried out to validate the advocated approach. The results obtained on standard benchmarking data sets show its promise.
Sub-graph Mining: Identifying Micro-architectures in Evolving Object-Oriented Software (2011)

Developers introduce novel and undocumented micro-architectures when performing evolution tasks on object-oriented applications. We are interested in understanding whether those organizations of classes and relations can bear, much like cataloged design and anti-patterns, potential harm or benefit to an object-oriented application. We present SGFinder, a sub-graph mining approach and tool based on an efficient enumeration technique to identify recurring micro-architectures in object-oriented class diagrams. Once SGFinder has detected instances of micro-architectures, we exploit these instances to identify their desirable properties, such as stability, or unwanted properties, such as change or fault proneness. We perform a feasibility study of our approach by applying SGFinder on the reverse-engineered class diagrams of several releases of two Java applications: ArgoUML and Rhino. We characterize and highlight some of the most interesting micro-architectures, e.g., the most fault prone and the most stable, and conclude that SGFinder opens the way to further interesting studies.
Characteristics of the Trochoidal Monochromator by Calculation of Electron Energy Distribution (1972)

The properties and characteristics of the trochoidal monochromator, improved by Stamatovic and Schulz for producing low-energy monoenergetic electrons, are investigated by means of a method of calculation of the electron energy distribution. By assuming that the angular divergence of the incident beam is approximately 10°, the calculated energy distribution has a half-intensity width of 0.015 eV compared to 0.02 eV measured by Stamatovic and Schulz. Further calculations show that by changing some of the operating conditions it is possible to gain either an improvement of about 35% in the resolving power for the same transmission, or an improvement up to 100% in the transmitted current intensity for the same resolving power.
Studies of Fluorinated Pyrimidines. XVIII. The Degradation of 5-Fluoro-2'-deoxyuridine and Related Compounds by Nucleoside Phosphorylase<sup>*</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies of Fluorinated Pyrimidines. XVIII. The Degradation of 5-Fluoro-2'-deoxyuridine and Related Compounds by Nucleoside Phosphorylase*G. D. Birnie, H. Kroeger, and Charles HeidelbergerCite this: Biochemistry 1963, 2, 3, 566–572Publication Date (Print):May 1, 1963Publication History Published online1 May 2002Published inissue 1 May 1963https://pubs.acs.org/doi/10.1021/bi00903a031https://doi.org/10.1021/bi00903a031research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Physicochemical Behaviour of Ternary System Based on Coconut Oil/C 12 E 8 / n -pentanol/water (2013)

Physicochemical properties of a system based on Coconut Oil, nonionic surfactant C 12 E 8 , cosurfactant n-pentanol and water has been studied. The phase behavior, effect of temperature and electrical conductivity of the system was studied at different surfactant (S) to cosurfactant (C) ratios, the ratios being 1 : 1, 1 : 1.5, 1 : 2 (w/w). Pseudoternary phase behavior of these ratios was studied, the phase diagrams generated distinguishes between monophasic/ isotropic and biphasic/anisotropic regions. The monophasic region was found to be a strong function of the S : C ratio. The largest monophasic region was obtained when the S : C ratio was 1 : 1, the monophasic region gradually depleted with decrease in amount of S in the order 1 : 1 > 1 : 1.5 > 1 : 2 . The effect of temperature was examined on the phase behavior of the system, and for all S : C ratios it was observed that the monophasic region decreased with increase in temperature. The electrical conductivity of the system increases with aqueous phase content indicating a transition from water-in-oil to oil-in-water microemulsions.
Cutaneous Feedback of Fingertip Deformation and Vibration for Palpation in Robotic Surgery (2015)

Despite its expected clinical benefits, current teleoperated surgical robots do not provide the surgeon with haptic feedback largely because grounded forces can destabilize the system's closed-loop controller. This paper presents an alternative approach that enables the surgeon to feel fingertip contact deformations and vibrations while guaranteeing the teleoperator's stability. We implemented our cutaneous feedback solution on an Intuitive Surgical da Vinci Standard robot by mounting a SynTouch BioTac tactile sensor to the distal end of a surgical instrument and a custom cutaneous display to the corresponding master controller. As the user probes the remote environment, the contact deformations, dc pressure, and ac pressure (vibrations) sensed by the BioTac are directly mapped to input commands for the cutaneous device's motors using a model-free algorithm based on look-up tables. The cutaneous display continually moves, tilts, and vibrates a flat plate at the operator's fingertip to optimally reproduce the tactile sensations experienced by the BioTac. We tested the proposed approach by having eighteen subjects use the augmented da Vinci robot to palpate a heart model with no haptic feedback, only deformation feedback, and deformation plus vibration feedback. Fingertip deformation feedback significantly improved palpation performance by reducing the task completion time, the pressure exerted on the heart model, and the subject's absolute error in detecting the orientation of the embedded plastic stick. Vibration feedback significantly improved palpation performance only for the seven subjects who dragged the BioTac across the model, rather than pressing straight into it.
Vision-based Interface Using-face and Hand Recognition with Attention (2002)

This paper discusses face and hand-sign recognition and its applications to a multi-camera system. We propose a vision-based interface that focuses on faces and hand for recognition. Using a stereo camera system, face and hand regions are detected by the referenced skin color method, and the distances of the targets are then estimated. The positions and sizes of targets are evaluated for tracking between consecutive frames. Two tracking cameras perform tracking of such targets as faces and hands, and also zoom in on the selected target to acquire an appropriately sized image for recognition. We experimented with a hierarchical linear discriminant analysis that distinguishes between faces and hands on the first step, and then recognizes face and hand-signs in each discriminant space by using four directional features. These experiments showed that our system could distinguish between faces and hands, as well as recognize face and hand-signs.
Site-specific terminal and internal labeling of RNA by poly(A) polymerase tailing and copper-catalyzed or copper-free strain-promoted click chemistry (2012)

The modification of RNA with fluorophores, affinity tags and reactive moieties is of enormous utility for studying RNA localization, structure and dynamics as well as diverse biological phenomena involving RNA as an interacting partner. Here we report a labeling approach in which the RNA of interest--of either synthetic or biological origin--is modified at its 3'-end by a poly(A) polymerase with an azido-derivatized nucleotide. The azide is later on conjugated via copper-catalyzed or strain-promoted azide-alkyne click reaction. Under optimized conditions, a single modified nucleotide of choice (A, C, G, U) containing an azide at the 2'-position can be incorporated site-specifically. We have identified ligases that tolerate the presence of a 2'-azido group at the ligation site. This azide is subsequently reacted with a fluorophore alkyne. With this stepwise approach, we are able to achieve site-specific, internal backbone-labeling of de novo synthesized RNA molecules.
Robust Min-Max Localization Algorithm (2006)

The advent of dedicated short range commu- nication (DRSC) devices — which are designed to support vehicle-to-vehicle and vehicle-to-infrastructure communication — promises a wide set of new active safety applications (e.g. a cooperative collision warning system based on vehicle-to-vehicle communication). One of the fundamental challenges for realizing these systems will be to accurately and reliably determine a vehicle's position with respect to its neighbours. We propose a distributed algorithm using inter-vehicle distance estimates to localize a vehicle among its neighbours. Given that the inter- vehicle distance measurements contain noise, we will present a robust min-max optimization algorithm that precisely predicts the vehicle position within a cluster. Simulation studies show that our algorithm outperforms previously proposed localization schemes.
Strong and Superhydrophobic Wood with Aligned Cellulose Nanofibers as a Waterproof Structural Material<sup>†</sup> (2020)

Summary of main observation and conclusion Lightweight structural materials are important for the energy efficiency of applications, particularly those in the building sector. Here, inspired by nature, we developed a strong, superhydrophobic, yet lightweight material by simple in situ growth of nano‐SiO 2 and subsequent densification of the wood substrate. In situ generation of SiO 2 nanoparticles both inside the wood channels and on the wood surfaces gives the material superhydrophobicity, with static and dynamic contact angles of 159.4 o and 3 o , respectively. Densification of the wood to remove most of the spaces among the lumen and cell walls results in a laminated, dense structure, with aligned cellulose nanofibers, which in turn contributes to a high mechanical strength up to 384.2 MPa (7‐times higher than natural wood). Such treatment enables the strong and superhydrophobic wood (SH‐Wood) to be stable and have excellent water, acid, and alkaline resistance. The high mechanical strength of SH‐Wood combined with its excellent structural stability in harsh environments, as well its low density, positions the strong and superhydrophobic wood as a promising candidate for strong, lightweight, and durable structural materials that could potentially replace steel.
Detection of the Malignant B Cell Clone in Multiple Myeloma Via High Throughput Sequencing Is Robust to Significant Levels of Somatic Hypermutation (2014)

Abstract Background: High-throughput sequencing (HTS) of antibody gene rearrangements is an emerging tool for minimal residual disease (MRD) monitoring in B cell malignancies in which the malignant clone harbors a monoclonal Ig heavy chain (IgH) and/or light chain (κ or λ) rearrangement. This approach has shown promise in B-ALL and CLL, but experience with this technique applied to samples from multiple myeloma patients is limited. Approach: We conducted HTS of PCR-amplified IgH (VDJ and DJ) rearrangements from bone marrow aspirates of 21 patients with various plasma cell dyscrasias (MM, MGUS, LPL) and peripheral blood of a patient with plasma cell leukemia. In 17/21 samples, an aliquot was enriched for CD138+ cells by immunomagnetic separation and analyzed separately. Dominant clones from enriched and un-enriched aliquots were compared to verify the malignant clonotype sequence(s). Disease burden in un-enriched samples was also evaluated by microscopy of the bone marrow aspirate smear and ranged from 0 (hemodilute) to 37% plasma cells. Results: In 19 out of 21 samples, a clearly dominant IgH gene rearrangement (>2.5% of total sequences, range 2.9-99.9%) was identified with clear separation from background frequency (at least 2.7-fold higher frequency than next most common clone). In 17/17 cases with paired CD138-enriched samples, the dominant sequences in the enriched and un-enriched samples were identical, indicating successful identification of the malignant clonal Ig rearrangements in the un-enriched sample. More than one IgH rearrangement suitable for longitudinally tracking the malignant clone was identified in 8 of 21 cases. The two cases without an expected, productive IgH rearrangement were IgG-κ and IgG-λ. This suggested that somatic hypermutation (SHM) in the primer binding sites might interfere with some clonal amplifications, so we investigated the degree of SHM in the VH segment of the 19 cases with at least one detected dominant Ig rearrangement. A total of 18 productive VDJ rearrangements were identified, and had SHM frequencies ranging from 2% to 19% in the sequenced portions of the rearranged VH gene. 8 myeloma clones harbored an identifiable DJ rearrangement, none of which showed evidence of SHM. Finally, 3 myeloma clones harbored nonproductive VDJ rearrangements, two with no SHM, and one with 2 SHM in 84 bp of the sequenced VH gene. Conclusion: HTS of Ig heavy and light chain rearrangements can successfully identify the malignant plasma cell clone in clinical specimens, including those with low disease burden and significant SHM. Application of this technique to MRD evaluation in multiple myeloma warrants further development. Disclosures Carlson: Adaptive Biotechnologies: Consultancy, Equity Ownership. Vogl:Celgene Corporation: Consultancy; Amgen: Consultancy; Millennium/Takeda: Research Funding; GSK: Research Funding; Acetylon: Research Funding. Stadtmauer:Janssen: Consultancy.
APRIL is overexpressed in cancer: link with tumor progression (2009)

Taken together, these data suggest that APRIL is a potential prognostic factor for a large array of malignancies.
The relationship between unpaired spin concentration, structure, and electrical conduction of a pyrolytic aromatic polyimide (1967)

Abstract When films of poly [N,N′‐(p,p′ ‐oxydiphenylene)pyromellitimide] are pyrolyzed in vacuum between 575 and 800°C., they are converted into products having electrical conductivities as high as 20 (ohm‐cm.) −1 measured at 25°C. This transformation of the polymer from an insulator into an electroconductor is accompanied by distinct changes in the electron paramagnetic resonance absorption (EPR) vs. time curves, x‐ray diffraction, elemental composition, and density. From the rates of EPR absorption, a tentative activation energy of 25 ± 3 kcal./mole was calculated for this internal transformation. The absence of polarization effects and the fact that repeated thermal cycling does not significantly diminish the observed electrical conduction suggest that it is electronic rather than ionic in character. The development of electrical conduction in the pyrolyzed polymer occurs well below the graphitization temperature and with the retention of considerable quantities of nitrogen and oxygen. Apparently a fused conjugated network with a large pool of π‐electrons and π‐orbital overlap develops and the reduction of interboundary resistance at sufficiently high temperatures causes the appearance of electrical conduction.
Bioglass?? Attenuates a Proinflammatory Response in Mouse Peritoneal Endotoxicosis (2002)

Bioglass is a bioactive, resorbable ceramic particle that was developed to assure binding to living tissues. Bioglass is currently employed to fill osseus defects in oral surgery, and it possesses both unique anti-inflammatory and antimicrobial properties. In an effort to determine whether Bioglass may be useful as an adjunct anti-inflammatory device in local inflammatory processes, we examined whether exposure of the peritoneal cavity to Bioglass would induce a pro- or anti-inflammatory response, and then modulate a subsequent proinflammatory response to endotoxin. Three- to fifty-milligram doses of 5 pm Bioglass were administered intraperitoneally in C57BL/6 mice. Total leukocyte, myeloperoxidase, and cytokine levels in the peritoneal wash fluid were determined. In addition, the peritoneal cavity was preexposed to Bioglass, and was then subjected to a subsequent endotoxin administration. All doses of Bioglass were found to induce a significant peritoneal IL-6 response; however, Bioglass did not induce a TNF-alpha, IL-1alpha, IL-10, or a white cell recruitment into the peritoneal lavage fluid. Pretreatment of the peritoneal cavity with Bioglass produced a transient reduction in the proinflammatory response to endotoxin. We conclude that exposure to Bioglass produces an IL-6 response without concurrent expression of TNF-alpha or IL-1alpha. Bioglass appears to transiently suppress the inflammatory response to endotoxin, possibly through the early induction of IL-6. These findings suggest that Bioglass may offer a unique approach in modifying the inflammatory response in local tissue compartments.
[The modified Johnson-Reid method--a practice model for coccidiosis monitoring in the fattening of young fowl?]. (1987)

Models of coccidiosis-monitoring known from literature are described. A suitable alternative of determining the coccidia status in a broiler population is the "modified Johnson-Reid method". This method makes a standardization of diagnostic finding and evaluation possible as well as a differentiated intestinal localization and the determination of coccidia incidence severity. In addition to the microscopic screening of the caecum contents--as described by Johnson-Reid--it appears necessary to take also swabs from parts of the duodenum and jejunum (near the Meckel's diverticulum). Subsequently this method is an important help for veterinarians working with broiler production, for diagnostic institutions as well as producers of anticoccidial agents, especially in regard to its documentation rate and the resulting consequences. In this way other diagnostic efficiency data in broiler production are significantly completed.
IBMG: Interpretable Behavioral Model Generator for Nonlinear Analog Circuits via Canonical Form Functions and Genetic Programming (2005)

The paper presents IBMG, an approach to generate behavioral models of nonlinear analog circuits, with the special distinction that it generates models that are compact and interpretable expressions which are not restricted to any pre-defined functional templates. IBMG outputs a small set of interpretable nonlinear differential equations that approximate the time-domain behavior of the circuit being modeled. The approach uses genetic programming (GP), which evolves functions, but GP has been heavily modified so that the behavioral expressions follow a special "canonical functional form" grammar to remain interpretable. IBMG has explicit error control; it provides a set of models that trade off complexity and accuracy. Experimental results on a strongly nonlinear latch circuit demonstrate the usefulness of IBMG.