gebhart/patrepeval huggingface dataset:
BAYESIAN ESTIMATION OF MARKOV DETERIORATION HAZARD MODEL (2007)

橋梁アセットマネジメントでは，目視検査結果を用いた統計的劣化予測に基づいてライフサイクル費用を算定する場合が多い．しかしながら，大半の施設管理者においてはデータの蓄積が十分ではなく，このことが統計的劣化予測手法の実用化の弊害となっている．そこで，本研究では予測の初期段階では専門技術者の先験情報により劣化予測結果を与え，目視検査データの蓄積とともに逐次予測結果を更新することが可能な方法論を提案する．具体的には，著者らが開発した統計的劣化予測手法であるマルコフ劣化ハザードモデルをマルコフ連鎖モンテカルロ法に基づくベイズ推定により更新する方法を提案する．さらに，実橋RC床版に対する目視検査データへの適用を通して，本手法の有効性を実証的に検証した．
Myocyte structure, function, and calcium kinetics in the cardiomyopathic hamster heart (1990)

The hereditary cardiomyopathic strain of the Syrian hamster has been studied extensively as a model of cardiomyopathy and heart failure. However, the primary defect underlying the cascade of events leading to heart failure has not been identified. In the present study, isolated cardiac cells were obtained for study from 8-mo-old cardiomyopathic (Bio 14.6) and age-matched normal hamsters (F1B). We examined the relationships among structure, contractile function, and calcium kinetics in these isolated cardiomyocytes. The cardiomyopathic myocytes were wider and longer than controls, and myopathic cells were less calcium tolerant. The sarcoplasmic reticulum and T-tubule systems from myopathic hearts were more abundant as determined by electron microscopy. The amplitude and velocity of contraction was decreased in cardiomyopathic cells, whereas diastolic relaxation velocity was not different between the two groups. The size of the rapidly exchangeable calcium pool determined by 45Ca2+ uptake was significantly increased in cardiomyopathic myocytes. Time-averaged cytosolic Ca2+ in these cells (472 +/- 60 nM) was significantly higher than control (260 +/- 15 nM) as measured by the fura-2 fluorescence ratio. When extracellular Ca2+ ([Ca2+]o) was increased to greater than 1.2 mM, the resulting increase in intracellular calcium concentration was less than that in normal control cells. The corresponding [Ca2+]o-induced increase in amplitude of cell motion was significantly attenuated in the cardiomyopathic cells compared with normal control myocytes. We conclude that distinct abnormalities of contractile function and calcium homeostasis can be identified in single cells isolated from cardiomyopathic hamster hearts.
Adrenal-Mediated Endogenous Metabolites Inhibit Puberty in Female Mice (1986)

While assessing a potential role of adrenal glands in the production of the hitherto unidentified puberty-delaying pheromone of female mice, the urinary volatile profiles of normal and adrenalectomized animals were quantitatively compared. Six components, whose concentrations were depressed after adrenalectomy, were identified: 2-heptanone, trans-5-hepten-2-one, trans-4-hepten-2-one, n-pentyl acetate, cis-2-penten-1-yl acetate, and 2,5-dimethylpyrazine. When these laboratory-synthesized chemicals were added (in their natural concentrations) to either previously inactive urine from adrenalectomized females or plain water, the biological activity was fully restored.
Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer. (1999)

Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by defective DNA mismatch repair, which results in genetic instability of tumors; however, only a few target genes have been recognized. Our previous study detected a low frequency of APC gene mutation (21%) in colorectal tumors from HNPCC patients, in contrast to a high frequency of APC gene alteration (>70%) in non-HNPCC tumors. Because both beta-catenin and ACP gene mutations have recently been shown to activate the same signaling pathway, we analyzed beta-catenin mutation in HNPCC tumors. A notable frequency of beta-catenin gene mutation (43%, 12 of 28) was found to occur in HNPCC colorectal tumors. Beta-catenin mutations were not detected in tumors with APC mutations. All beta-catenin mutations detected in HNPCC tumors existed within the regulatory domain of beta-catenin. Immunohistochemical staining of tumors with this mutation showed accumulation of beta-catenin protein in nuclei. These and previous data from our laboratory suggest that activation of the beta-catenin-Tcf signaling pathway, through either beta-catenin or APC mutation, contributes to HNPCC colorectal carcinogenesis in approximately 65% of cases.
Galectin-1 Interacts with the α5β1 Fibronectin Receptor to Restrict Carcinoma Cell Growth via Induction of p21 and p27 (2005)

Surface binding of galectin family members has the potential to link distinct glycan structures to growth regulation. Therefore, we addressed the antiproliferative potential of galectin-1 (Gal-1) in a panel of carcinoma cell lines. We discovered growth inhibition by Gal-1 in epithelial tumor cell lines from different origins and provide evidence that this effect requires functional interaction with the alpha5beta1 integrin. Antiproliferative effects result from inhibition of the Ras-MEK-ERK pathway and consecutive transcriptional induction of p27. We have further identified two Sp1-binding sites in the p27 promoter as crucial for Gal-1 responsiveness. Inhibition of the Ras-MEK-ERK cascade by Gal-1 increased Sp1 transactivation and DNA binding due to reduced threonine phosphorylation of Sp1. Furthermore, Gal-1 induced p21 transcription and selectively increased p27 protein stability. Gal-1-mediated accumulation of p27 and p21 inhibited cyclin-dependent kinase 2 activity and ultimately resulted in G(1) cell cycle arrest and growth inhibition. These data define a novel mechanism whereby Gal-1 regulates epithelial tumor cell homeostasis via carbohydrate-dependent interaction with the alpha5beta1 integrin.
Controlled Synthesis of Co<sub>3</sub>O<sub>4</sub>Nanoparticles through Oriented Aggregation (2004)

Monodispersed 5-nm Co3O4 nanocrystals are prepared by thermal decomposition, in long carbon chain alcohols, of the intermediate product Co(NO3)2·7C6H13OH, which is first obtained through the reaction of Co(NO3)2·6H2O with n-hexanol. A designed addition of water into the reaction system causes an oriented aggregation of the primary nanocrystals resulting in spherical mesoporous-like nanostructures from tens to several hundred nanometers. IR, XRD, UV−visible, and 1H NMR analysis techniques are applied to determine the intermediate product, and the thermal-decomposition mechanism is identified through gas chromatography-mass spectrum analysis. XRD, TEM, HRTEM, SAED, and TG/MS are used to characterize the oriented aggregating nanostructures. The binder effect of water molecules on the oriented aggregation of the building blocks and the capping effect of the alcohols on the particle surface during the process are discussed.
Measuring Portfolio Risk Using Quasi Monte Carlo Methods (1998)

We consider the application of Quasi Monte Carlo methods to risk measurement. A scenario generation technique based on low discrepancy Sobol sequences is compared to one based on pseudo-random number generation. The comparison methodology includes the calculation of the number of scenarios necessary to guarantee the required accuracy level of the Value-at-Risk estimate and the calculation of the relative performance of the two methods. The methodology is illustrated by a case study of a multi-currency portfolio. We demonstrate that Quasi Monte Carlo methods significantly improve the performance of the portfolio simulation and, therefore, reduce the time to obtain reliable risk measurements.
The Absence of Quadrupolar Nuclei Facilitates Efficient <sup>13</sup>C Hyperpolarization via Reversible Exchange with Parahydrogen (2017)

Nuclear spin hyperpolarization techniques are revolutionizing the field of <sup>13</sup> C molecular MRI. While dissolution dynamic nuclear polarization (d-DNP) is currently the leading technique, it is generally slow (requiring ≈1 h) and costly (≈$USD10<sup>6</sup> ). As a consequence of carbon's central place in biochemistry, tremendous progress using <sup>13</sup> C d-DNP bioimaging has been demonstrated to date including a number of clinical trials. Despite numerous attempts to develop alternatives to d-DNP, the competing methods have faced significant translational challenges. Efficient hyperpolarization of <sup>15</sup> N, <sup>31</sup> P, and other heteronuclei using signal amplification by reversible exchange (SABRE) has been reported in 2015, but extension of this technique to <sup>13</sup> C has proven to be challenging. Here, we present efficient hyperpolarization of <sup>13</sup> C nuclei using micro-Tesla SABRE. Up to ca. 6700-fold enhancement of nuclear spin polarization at 8.45 T is achieved within seconds, corresponding to P<sub>13C</sub> ≈4.4 % using 50 % parahydrogen (P<sub>13C</sub> >14 % would be feasible using more potent ≈100 % parahydrogen). Importantly, the <sup>13</sup> C polarization achieved via SABRE strongly depends not only upon spin-lattice relaxation, but also upon the presence of <sup>15</sup> N (I=1/2) versus quadrupolar <sup>14</sup> N (I=1) spins in the site binding the hexacoordinate Ir atom of the catalytic complex. We show that different <sup>13</sup> C nuclei in the test molecular frameworks-pyridine and acetonitrile-can be hyperpolarized, including <sup>13</sup> C sites up to five chemical bonds away from the exchangeable hydrides. The presented approach is highly scalable and can be applied to a rapidly growing number of biomolecules amendable to micro-Tesla SABRE.
AP selection algorithm for VoIP services in mixed traffic WLAN environment (2008)

Recent rapid developments of high-speed wireless access technologies enable us to use real-time multimedia services as well as legacy non-real-time services via wireless access systems. These multimedia services require QoS (Quality of Service), such as low PLR (Packet Loss Rate) and short delay time. To provide QoS guarantee in wireless LAN (Local Area Network) environment, this paper proposes a new AP (Access Point) selection algorithm, RPFA (Real-time Prioritized Fairness Association), for large-scale wireless LAN system, which is based on capacity utilization of an AP and the number of associated stations to an AP. This algorithm is effective when real-time UDP (User datagram Protocol) traffic and non-real-time TCP (Transmission Control Protocol) traffic coexist. Simulation results show improvements of VoIP (Voice over Internet Protocol) PLR, delay time and R-values for real-time VoIP application and throughput fairness for non-real time FTP application, and also show expansion of a VoIP capacity of wireless LAN system compared to legacy algorithms.
Notes on Some South Slav Beliefs and Festivals. (1926)

(1926). Notes on Some South Slav Beliefs and Festivals. Folklore: Vol. 37, No. 1, pp. 35-75.
Effects of TU-199, a novel H+, K+-ATPase inhibitor, on gastric acidsecretion and gastroduodenal ulcers in rats (1999)

We studied the effects of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion and gastroduodenal lesions in rats in comparison with those of omeprazole. TU-199 inhibited hog gastric H+, K(+)-ATPase activity and its potency was almost equal to that of omeprazole (IC50 = 6.2 and 4.2 microM, respectively). In vivo, TU-199 inhibited basal gastric acid secretion in pylorus-ligated rats in a dose-dependent manner (ED50 = 4.2 mg/kg p.o.). In gastric fistula rats. TU-199 (2.5 and 5 mg/kg i.d.) also inhibited gastric acid secretion stimulated by histamine, carbachol or tetragastrin. Furthermore, TU-199 prevented the formation of water-immersion restraint stress-, pylorus ligation- and indomethacin-induced gastric lesions, and mepirizole-induced duodenal ulcer in rats. These antisecretory and antiulcer effects of TU-199 were 2-4 times more potent than those of omeprazole. The results demonstrate that TU-199 potently inhibits the acid secretion and formation of ulcers in various experimental rat models via an inhibition of H+, K(+)-ATPase. These findings suggest that TU-199 may have a beneficial effect against peptic ulcer disease in humans.
Stability of Divalent Europium in an Ionic Liquid:  Spectroscopic Investigations in 1-Methyl-3-butylimidazolium Hexafluorophosphate (2003)

In this work, devoted to 1-methyl-3-butylimidazolium hexafluorophosphate ionic liquid (BumimPF(6)), the importance of the purity of the solvent for spectroscopic investigations is highlighted. Results from small angle X-ray scattering indicate that the pure solvent exhibits a local organization. Europium(II), which appears to be unusually stable in BumimPF(6), is characterized by spectroscopic techniques (absorption, luminescence). Solvation of Eu(II) in BumimPF(6) and complexation effects in the presence of the crown ether 15C5 solubilized in the ionic liquid are discussed.
The mobile phone meets the Internet (1999)

Fifteen years ago mobile telephones were an exotic extravagance. Today, as cellular phones, they are often given away as freebies in support of marketing schemes and product promotions. Having become a mainstream voice communication medium, they are poised to take on new challenges, transmitting (fairly) high-speed data, video and multimedia traffic as well as voice signals to users on the move. The technology needed to tackle the challenges is known as third-generation cellular telephony. From this viewpoint, the early analog cell phones are labeled the first generation, and similar systems featuring digital radio technologies are labeled the second generation. These newer phones have appeared alongside of, and in some places have replaced, their analog forebears.
CHEMICAL AND PHYSICAL PROPERTIES OF UPGRADED BROWN COAL (2006)

Results of proximate analyses indicate that inherent moisture of the upgraded coals decrease signifi- cantly compared to that of the raw coals. Hence, the calorific value of the upgraded coals increases. The ash content of the upgraded coals did not change obviously due to the UBC process which was conducted at low temperature. However, the volatile matter content increase slightly due to the residue plugs over coal pores to prevent re-absorb of moisture. From ultimate analyses, carbon content of the upgraded coals increases, whereas the hydrogen and oxygen contents decrease. The UBC process hardly effects to the sulfur and nitrogen contents. The equilibrium moisture of the upgraded coals was determined by using ASTM Standard method, most of them were less than 9%. The functional group of C-H and C=O of the upgraded coals were slightly less than that of the raw coals. The aromaticity of coal, all of the upgraded coals was increase. The petrography of both the raw and the upgraded coals indicates that the mean vitrinite reflectance was slightly higher in the upgraded coal compared to that of the raw coal. There was no significant quantity and textural differences of maceral in both coals. The specific surface area of the upgraded coals was lower than that of the raw coals due to the plugging of pore structure and shrinkage by residual oil addition. The briquettability of Upgraded coal briquette according to drop shatter test and compressive strength indicates good characteristics of briquette.
TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content (2014)

Genome-wide association studies have identified a locus on chromosome 19 associated with plasma triglyceride (TG) concentration and nonalcoholic fatty liver disease. However, the identity and functional role of the gene(s) responsible for these associations remain unknown. Of 19 expressed genes contained in this locus, none has previously been implicated in lipid metabolism. We performed gene expression studies and expression quantitative trait locus analysis in 206 human liver samples to identify the putative causal gene. Transmembrane 6 superfamily member 2 (TM6SF2), a gene with hitherto unknown function, expressed predominantly in liver and intestine, was identified as the putative causal gene. TM6SF2 encodes a protein of 351 amino acids with 7-10 predicted transmembrane domains. Otherwise, no other protein features were identified which could help to elucidate the function of TM6SF2. Protein subcellular localization studies with confocal microscopy demonstrated that TM6SF2 is localized in the endoplasmic reticulum and the ER-Golgi intermediate compartment of human liver cells. Functional studies for secretion of TG-rich lipoproteins (TRLs) and lipid droplet content were performed in human hepatoma Huh7 and HepG2 cells using confocal microscopy and siRNA inhibition and overexpression techniques. In agreement with the genome-wide association data, it was found that TM6SF2 siRNA inhibition was associated with reduced secretion of TRLs and increased cellular TG concentration and lipid droplet content, whereas TM6SF2 overexpression reduced liver cell steatosis. We conclude that TM6SF2 is a regulator of liver fat metabolism with opposing effects on the secretion of TRLs and hepatic lipid droplet content.
Genes differentially expressed with malignant transformation and metastatic tumor progression of murine squamous cell carcinoma (1997)

Molecular changes occurring with tumor formation and metastasis need to be identified in order to define novel markers and targets for chemoprevention and therapy. Cell lines from a multistage model of murine squamous cell carcinoma were analyzed for differences in gene expression using mRNA differential display. mRNA was isolated from primary keratinocytes, an in vitro transformed keratinocyte line (Pam 212), and three metastatic cell lines derived from Pam 212 following tumor progression in vivo. cDNA was synthesized by reverse transcription and amplified by PCR using 72 primer combinations to screen and compare approximately 3,600 sequences. Five cDNAs with a differential expression pattern confirmed by Northern blot analysis were cloned and sequenced, revealing homology with known genes. The gene encoding tropomyosin α was preferentially expressed in primary keratinocytes; genes for tyrosine kinase Yes-associated protein (YAP65) and ribosomal protein L18a were preferentially expressed in transformed and metastatic tumor cell lines; and genes for the Gro-α family cytokine KC and antigen Sp17 exhibited increased expression in the three metastatic cell lines. The structure and function of the genes identified suggest that they may possibly be linked to cell shape and motility, signal transduction, protein synthesis, growth, granulocyte chemotaxis, and angiogenesis. This study demonstrates the ability of mRNA differential display to detect altered gene expression in this tumor progression model of murine squamous cell carcinoma, and the potential usefulness of this approach for identification of candidate genes as chemoprevention markers and targets. J. Cell. Biochem. Suppls. 28/29:90–100. Published 1998 Wiley-Liss, Inc.1 This article is a US Government work and, as such, is in the public domain in the United States of America.
Design of multi-mode erbium-doped fiber amplifiers for low mode-dependent gain (2012)

Erbium-doped fiber amplifiers for 12 signal modes (six spatial modes in two polarizations) are studied by numerically solving multi-mode rate equations. Mode-dependent gains are compared for different numerical apertures, index profiles and doping profiles.
Satellite AIS – Developing Technology or Existing Capability? (2012)

The Automatic Identification System (AIS) is an integral element in vessel tracking. But what about ‘Satellite AIS’? Is Satellite AIS a viable, current and effective tool to assist in vessel tracking? This paper will present the basic premise of reception of AIS by Low Earth Orbit (LEO) satellites. It will identify the technical aspects, present practical applications of Satellite AIS and look at implications for global tracking of vessels.
Robust Computational Algorithms for Dynamic Interface Tracking in Three Dimensions (2000)

Front tracking provides sharp resolution of wave fronts through the active tracking of interfaces between distinct materials. A major challenge to this method is to handle changes in the interface topology. We describe two algorithms, implemented in the front tracking code FronTier, to model dynamic changes in three-dimensional interfaces. The two methods can be combined to give a hybrid method that is superior to each individual method. The success of these algorithms is shown by simulations of Rayleigh--Taylor instability, which is an interfacial instability driven by an acceleration directed across a material interface. Our numerical results are validated by comparing the numerical computation of the velocity of a single rising bubble with an analytic model for the bubble velocity.
Justice Deferred: A Fifty-Year Perspective on Japanese-Internment Historiography (1992)

Research Article| July 01 1992 Justice Deferred: A Fifty-Year Perspective on Japanese-Internment Historiography Gerald Stanley Gerald Stanley Search for other works by this author on: This Site PubMed Google Scholar Southern California Quarterly (1992) 74 (2): 181–206. https://doi.org/10.2307/41171622 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Cite Icon Cite Search Site Citation Gerald Stanley; Justice Deferred: A Fifty-Year Perspective on Japanese-Internment Historiography. Southern California Quarterly 1 July 1992; 74 (2): 181–206. doi: https://doi.org/10.2307/41171622 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentSouthern California Quarterly Search This content is only available via PDF. Copyright 1992 Historical Society of Southern California Article PDF first page preview Close Modal You do not currently have access to this content.
The Use of Egg Yolk in Ice Cream (1929)

Summary 1.The improvement in the whipping qualities of ice cream mixes resulting from the use of egg yolk is dependent upon: (a) the composition of the mix; (b) the age of the mix, and (c) the concentration of egg yolk used. 2.The whipping qualities of relatively heavy, slow freezing mixes are improved to a greater extent by egg yolk than are mixes of comparatively low solid content. 3.Egg yolk facilitates the freezing of fresh mixes irrespective of their composition. 4.The improvement in whipping qualities noted is in most cases in direct proportion to the concentration of egg yolk present. 5.Egg yolk, used in a concentration of 0.5 per cent or less, will exert but little or no influence on the body, texture, appearance, or flavor of ice cream containing sufficient milk solids and sugar. 6.An egg yolk flavor was considered objectionable by many people and it was most apparent in low solid mixes. 7.The results reported in this paper probably apply only when the same type of freezer, same brine temperature, and mixes of the same composition are used that were employed in conducting these experiments.
The Effects of Risk, Inflation and Dividend Yield on Common Stock Returns: The case of Korea (1989)

This study examines whether market equilibrium models of capital asset prices have any empirical validity in the Korean stock market, which is thin and relatively under-developed. In any study of the Korean stock market, the impurity of its ex post stock price and the attendant presumption of suspected non-normality of the stock return distribution cannot be ignored. This study finds that the Capital Asset Pricing Model (CAPM) has some explanatory power in the Korean stock market. In particular when data are segmented by time periods, the results tend to validate the general premises of the CAPM for the most recent period, i.e., between 1984 and 1987. [313]