gebhart/patrepeval huggingface dataset:
The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks (2009)

The Slx5/Slx8 protein complex, a heterodimeric SUMO-targeted ubiquitin ligase, plays an important role in genomic integrity. Slx5/Slx8 is believed to interact with sumoylated proteins that reside in the nuclei of budding yeast cells. In this complex, Slx5, owing to at least two SUMO interacting motifs (SIMs), has been proposed to be the targeting subunit of the Slx8 ubiquitin ligase. However, little is known about the exact subnuclear localization and targets of Slx5/Slx8. In this study we show that Slx5, but not Slx8, forms prominent nuclear foci. The formation of these foci depends on SUMO and a SIM in Slx5. Therefore, we investigated the subnuclear localization and potential chromatin association of Slx5. Using co-localization studies in live cells and fixed chromatin, we were able to localize Slx5 to DNA damage induced foci of Rad52 and Rad9, two proteins involved in the cellular response to DNA damage. Subsequent chromatin immunoprecipitation (ChIP) studies revealed that Slx5 is associated with HO endonuclease induced chromosome breaks. Surprisingly, real-time PCR analysis of Slx5 ChIPs revealed that the level of Slx5 at HO breaks in an slx8 deletion background is reduced about 4-fold. These results indicate that the DNA-damage targeting of Slx5/Slx8 depends on formation of the heterodimer and that this occurs at a subset of nuclear foci also containing DNA damage repair and checkpoint factors.
Altered expression and in vivo lung function of protease-activated receptors during influenza A virus infection in mice (2004)

Protease-activated receptors (PARs) are widely distributed in human airways, and recent evidence indicates a role for PARs in the pathophysiology of inflammatory airway disease. To further investigate the role of PARs in airway disease, we determined the expression and function of PARs in a murine model of respiratory tract viral infection. PAR-1, PAR-2, PAR-3, and PAR-4 mRNA and protein were expressed in murine airways, and confocal microscopy revealed colocalization of PAR-2 and cyclooxygenase (COX)-2 immunostaining in basal tracheal epithelial cells. Elevated levels of PAR immunostaining, which was particularly striking for PAR-1 and PAR-2, were observed in the airways of influenza A/PR-8/34 virus-infected mice compared with sham-infected mice. Furthermore, increased PAR-1 and PAR-2 expression was associated with significant changes in in vivo lung function responses. PAR-1 agonist peptide potentiated methacholine-induced increases in airway resistance in anesthetized sham-infected mice (and in indomethacin-treated, virus-infected mice), but no such potentiation was observed in virus-infected mice. PAR-2 agonist peptide transiently inhibited methacholine-induced bronchoconstriction in sham-infected mice, and this effect was prolonged in virus-infected mice. These findings suggest that during viral infection, the upregulation of PARs in the airways is coupled to increased activation of COX and enhanced generation of bronchodilatory prostanoids.
Sensing Performance of Energy Detector With Correlated Multiple Antennas (2009)

This paper describes the derivation of detection and false-alarm probabilities for energy detectors in cognitive radio networks when a sensing node of the secondary system has correlated multiple antennas. The sensing performance degradation due to the antenna correlation is then investigated based on the performance analysis. The conclusions of the analysis are verified by numerical simulation results.
The challenge of accurate software project status reporting: a two-stage model incorporating status errors and reporting bias (2002)

Software project managers perceive and report project status. Recognizing that their status perceptions might be wrong and that they may not faithfully report what they believe, leads to a natural question-how different is true software project status from reported status? Here, the authors construct a two-stage model which accounts for project manager errors in perception and bias that might be applied before reporting status to executives. They call the combined effect of errors in perception and bias, project status distortion . The probabilistic model has roots in information theory and uses discrete project status from traffic light reporting. The true statuses of projects of varying risk were elicited from a panel of five experts and formed the model input. The same experts estimated the frequency with which project managers make status errors, while the authors created different bias scenarios in order to investigate the impact of different bias levels. The true status estimates, error estimates, and bias levels allow calculation of perceived and reported status. The results indicate that at the early stage of the development process most software projects are already in trouble, that project managers are overly optimistic in their perceptions, and that executives receive status reports very different from reality, depending on the risk level of the project and the amount of bias applied by the project manager. Key findings suggest that executives should be skeptical of favorable status reports and that for higher risk projects executives should concentrate on decreasing bias if they are to improve the accuracy of project reporting.
Investigation of cobalt redox mediators and effects of TiO<sub>2</sub> film topology in dye-sensitized solar cells (2016)

Cobalt complexes represent interesting alternative redox mediators in dye-sensitized solar cells, with weak visible light absorption and a wide variety in redox potentials. Its diffusion in mesoporous TiO<sub>2</sub> may, however, limit its performance.
CHERN CLASSES OF LOCAL COMPLETE INTERSECTIONS WITH ISOLATED SINGULARITIES(Singularities and Complex Analytic Geometry) (1998)

Mechanistic insights into human disease may enable the development of treatments that are effective in broad patient populations. The confluence of gene-editing technologies, induced pluripotent stem cells, and genome-wide association as well as DNA sequencing studies is enabling new approaches for illuminating the molecular basis of human disease. We discuss the opportunities and challenges of combining these technologies and provide a workflow for interrogating the contribution of disease-associated candidate genetic variants to disease-relevant phenotypes. Finally, we discuss the potential utility of human pluripotent stem cells for placing disease-associated genetic variants into molecular pathways.
PERTUSSIS (1975)

Pertussis as an infectious disease exhibits a number of unusual features, both with respect to its epidemiology and to the interaction of the bacteia with the infected host. Evidence that a virus may in some cases be the etiology of the syndrome has been reviewed and seems to be have been established in certain instances. Pertussis caused by a virus would not be difficult to accept insofar as the respiratory manifestations of the disease are concerned. It is difficult, however, to reconcile the hematologic changes of pertussis with what is presently known about the usual virus infection of humans. The clinical syndrome itself is suficiently unique as to be recognized in most cases. The use of antibiotics has considerably reduced the mortality of the disease by allowing treatment of complications. The other serious complication of disease, pertussis encephalopathy, remains a problem. The possible occurrence of hypoglycemia during pertussis has been noted and deserves further documentation especially in that it may contribute to the encephalopathy...
Investigation into the impact of PCC parameters on voltage stability in a DFIG wind farm (2017)

Short Circuit Capacity (SCC), Short Circuit Ratio (SCR), and the system X/R ratio are the most important parameters in dictating voltage stability at the Point of Common Coupling of distribution networks connected to Wind Power Plant (WPP). This paper investigates the effect of SCC, X/R, and SCR on important voltage stability criteria at distribution network interconnection points for WPPs. These criteria are: voltage profile, maximum permissible active power can be injected by WPP, step-voltage variation due to changes in wind power generation, and reactive power requirements. Analysis studies have been carried out using IEEE standard distribution systems connected to Double Fed Induction Generator (DFIG)-Based WPPs. The results demonstrate that the voltage stability requirements are hardly provided at connection points with a small SCC, SCR and X/R values. These findings will aid in guiding decisions regarding the selection of feasible networks to which WPPs can be connected to where grid code requirements would be satisfied.
Bacillus cereus and related species. (1993)

Bacillus cereus is a gram-positive aerobic or facultatively anaerobic spore-forming rod. It is a cause of food poisoning, which is frequently associated with the consumption of rice-based dishes. The organism produces an emetic or diarrheal syndrome induced by an emetic toxin and enterotoxin, respectively. Other toxins are produced during growth, including phospholipases, proteases, and hemolysins, one of which, cereolysin, is a thiol-activated hemolysin. These toxins may contribute to the pathogenicity of B. cereus in nongastrointestinal disease. B. cereus isolated from clinical material other than feces or vomitus was commonly dismissed as a contaminant, but increasingly it is being recognized as a species with pathogenic potential. It is now recognized as an infrequent cause of serious nongastrointestinal infection, particularly in drug addicts, the immunosuppressed, neonates, and postsurgical patients, especially when prosthetic implants such as ventricular shunts are inserted. Ocular infections are the commonest types of severe infection, including endophthalmitis, panophthalmitis, and keratitis, usually with the characteristic formation of corneal ring abscesses. Even with prompt surgical and antimicrobial agent treatment, enucleation of the eye and blindness are common sequelae. Septicemia, meningitis, endocarditis, osteomyelitis, and surgical and traumatic wound infections are other manifestations of severe disease. B. cereus produces beta-lactamases, unlike Bacillus anthracis, and so is resistant to beta-lactam antibiotics; it is usually susceptible to treatment with clindamycin, vancomycin, gentamicin, chloramphenicol, and erythromycin. Simultaneous therapy via multiple routes may be required.
Natural Occurrence, Syntheses, and Applications of Cyclopropyl-Group-Containing α-Amino Acids. 2. 3,4- and 4,5-Methanoamino Acids (2007)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNatural Occurrence, Syntheses, and Applications of Cyclopropyl-Group-Containing α-Amino Acids. 2. 3,4- and 4,5-Methanoamino AcidsFarina Brackmann and Armin de MeijereView Author Information Institut für Organische und Biomolekulare Chemie der Georg-August-Universität Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany Cite this: Chem. Rev. 2007, 107, 11, 4538–4583Publication Date (Web):October 18, 2007Publication History Received3 April 2007Published online18 October 2007Published inissue 1 November 2007https://doi.org/10.1021/cr0784083Copyright © 2007 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2128Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (1 MB) Get e-AlertsSUBJECTS:Molecular structure,Monomers,Peptides and proteins,Reaction products,Receptors Get e-Alerts
Covalent attachment of DNA oligonucleotides to glass (1997)

A method for synthesizing DNA directly on glass is presented. The process is based on pretreatment of glass with boiling hydrochloric acid, thus exposing the hydroxyl groups of the glass. Phosphite-triester chemistry was used to directly attach the first nucleotide to a glass plate via a covalent bond between the hydroxyl group of the glass and the phosphate group of the protected deoxyribonucleotide. Standard molecular biology procedures, such as ligation and restriction digest, were efficiently performed on the glass synthesized oligonucleotide, with the added benefit of extreme ease of handling.
Object Detection by Spectropolarimeteric Imagery Fusion (2008)

In the past few years, imaging spectroscopy has been widely used. However, it only acquires intensity information in a narrow electromagnetic band, ignoring the polarimetric information of the electromagnetic wave and resulting in inaccurate object detection. According to electromagnetic theory, the reflected spectral signature depends on the elemental composition of objects residing within the scene, and the radiation's polarization characteristic is sensitive to surface features, such as relative smoothness and conductance. Independently, spectral and polarimetric features give incomplete representations of an object of interest. These representations are complementary, and it is expected that the combination of complementary information will reduce false alarms, improve confidence in target identification, and improve the quality of the scene description. Imaging spectropolarimetric technology as a new sensing method can acquire polarimetric information at narrow electromagnetic bands, but there are a few results showing how to combine these complementary features to detect objects in clutter. In this paper, a spectropolarimetric projection scheme is proposed to divide the spectropolarimetric data set into two parts: (1) a polarimetric spectrum data set and (2) a polarimetric data cube. Then, the polarimetric spectrum anomaly feature extraction method is used to deal with the polarimetric spectrum data set, and the adaptive polarimetric information fusion method is proposed to extract the feature from the polarimetric data cube. Finally, these features are combined by the Choquet integral to achieve better detection performance. The algorithm is applied to one complex scene, and detailed detection performance is evaluated.
The change and function of autophagy in nonalcoholic fatty liver disease (2017)

Autophagy is a pathway of degradation dependent on lysosome. A number of studies reported autophagy was involved in the occurrence and development of nonalcoholic fatty liver disease (NAFLD). Autophagy is enhanced in the early stage of NAFLD, and can delay the progress of NAFLD by inhibiting the secondary stroke which can induce NAFLD. In the late stage of NAFLD, degradation of autophagy related gene (Atg)7, activation of excessive mammalian rapamycin target protein pathway, hyperinsulinemia, dysfunction of autophagy-lysosome membrane protein hydrolysis, change of lipid composition in autophagosome and lysosome membrane, increase of calcium in the hepatocyte can inhibit autophagy, thus aggravate NAFLD.


Key words: 
Autophagy; Nonalcoholic fatty liver disease; Mammalian rapamycin target protein
France: Financial System Stability Assessment (2012)

The key macro-relevant findings of the Financial System Stability Assessment (FSSA) are as follows: France's financial system has shown resilience to severe market pressures but faces challenges. While its structure has contributed to solid profit generation, the crisis exposed the risks posed by the banks' size, complexity, and dependence on wholesale funding. The larger banks have been actively restructuring their balance sheets-moving to more stable sources of funding; reducing their cross-border presence; and building up capital. They remain, however, vulnerable to sustained disruptions in funding markets and reduced profitability, which would cause delays in meeting capital-raising plans.
Optimal Design and Real-Time Control for Energy Management in Electric Vehicles (2011)

To extend the lithium-ion (Li-ion) battery cycle life, an active combination of an ultracapacitor (UC) with an energy-dense Li-ion battery is shown as a promising approach for electric vehicles (EVs) and plug-in hybrid electric vehicles (PHEVs). In this paper, the problem of the sizing of the Li-ion battery and UC, as well as the degree of hybridization between the UC power and battery power, is approached from a new perspective, i.e., by solving an optimization problem to minimize fuel consumption. To implement this optimized power sharing in real time, a novel energy management strategy is proposed, which includes battery power reference generation, UC state-of-charge regulation, and forecast control based on the driver commands. Finally, simulations and experiments in which the flywheel + generator + controlled load is used to emulate the vehicle drivetrain are provided to verify the reduced stress on the battery current and the improved fuel economy achieved by the proposed method.
A photonic ATM backbone network (2002)

A photonic ATM backbone network that uses package-multiplexing is proposed to transfer ATM cells over ultra-high-speed trunk lines. The large-capacity lines that will be required to support broad-band services in the 21st century will have difficulty handling signals of more than 10 Gbps with electrical ATM switching systems because of size and power consumption constraints. A practical alternative that uses current technology is a photonic switching system that combines optical switches and electrical control circuits. The bottleneck in such a system would be the header processing capability of the electrical circuits. This proposed network first packs several cells into large packets called "packages" and then transfers the packages over ultra-high-speed optical lines. This photonic ATM backbone network will make it possible to build flexible and efficient cell transport networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Organic and solution-processed tandem solar cells with 17.3% efficiency (2018)

Although organic photovoltaic (OPV) cells have many advantages, their performance still lags far behind that of other photovoltaic platforms. A fundamental reason for their low performance is the low charge mobility of organic materials, leading to a limit on the active-layer thickness and efficient light absorption. In this work, guided by a semi-empirical model analysis and using the tandem cell strategy to overcome such issues, and taking advantage of the high diversity and easily tunable band structure of organic materials, a record and certified 17.29% power conversion efficiency for a two-terminal monolithic solution-processed tandem OPV is achieved.
Monoclonal antibodies to intermediate filament proteins of human cells: unique and cross- reacting antibodies (1982)

Monoclonal antibodies were generated against the intermediate filament proteins of different human cells. The reactivity of these antibodies with the different classes of intermediate filament proteins was determined by indirect immunofluorescence on cultured cells, immunologic indentification on SDS polyacrylamide gels ("wester blot" experiments), and immunoperoxidase assays on intact tissues. The following four antibodies are described: (a) an antivimentin antibody generated against human fibroblast cytoskeleton; (b), (c) two antibodies that recognize a 54-kdalton protein in human hepatocellular carcinoma cells; and (d) an antikeratin antibody made to stratum corneum that recognizes proteins of molecular weight 66 kdaltons and 57 kdaltons. The antivimentin antibody reacts with vimentin (58 kdaltons), glial fibrillary acidic protein (GFAP), and keratins from stratum corneum, but does not recognize hepatoma intermediate filaments. In immunofluorescence assays, the antibody reacts with mesenchymal cells and cultured epithelial cells that express vimentin. This antibody decorates the media of blood vessels in tissue sections. One antihepatoma filament antibody reacts only with the 54 kdalton protein of these cells and, in immunofluorescence and immunoperoxidase assays, only recognizes epithelial cells. It reacts with almost all nonsquamous epithelium. The other antihepatoma filament antibody is much less selective, reacting with vimentin, GFAP, and keratin from stratum corneum. This antibody decorates intermediate filaments of both mesenchymal and epithelial cells. The antikeratin antibody recognizes 66-kdalton and 57-kdalton proteins in extracts of stratum corneum and also identifies proteins of similar molecular weights in all cells tested. However, by immunofluorescence, this antibody decorates only the intermediate filaments of epidermoid carcinoma cells. When assayed on tissue sections, the antibody reacts with squamous epithelium and some, but not all, nonsquamous epithelium. Therefore this antistratum corneum antibody and the anti-54-kdalton antibody identify unique epitopes present in the various cytokeratin molecules of epithelial cells. None of the hybridoma antibodies react with neurofilament proteins. The different patterns of reactivity of these antibodies suggest that many of the immunologically distinct intermediate filament proteins contain common antigenic determinants.
Is there a healthy future for pedigree dogs? (2011)

As veterinary nurses the ethical, health and welfare issues surrounding the breeding of pedigree dogs with exaggerated anatomical features are a part of our everyday working lives. By reviewing the evidence of various reports commissioned by organizations such as the Royal Society for the Prevention of Cruelty of Animals (RSPCA), The Kennel Club, Dogs Trust and the Associate Parliamentary Group for Animal Welfare that have a vested interest in solving the ongoing issues of the health and welfare of certain breeds, this paper aims to highlight the role the veterinary profession can play in ensuring welfare compatible dog breeding in the future, as well as provide an ethical framework for use in veterinary practice.
Association with B‐cell‐antigen receptor with protein‐tyrosine kinase p72<sup>syk</sup> and activation by engagement of membrane IgM (1993)

We have demonstrated that a 72-kDa non-receptor-type protein-tyrosine kinase (p72syk) was co-immunoprecipitated with membrane IgM in digitonin lysates of porcine tonsillar cells and was rapidly activated following the engagement of membrane IgM. This activation was occurred within 5 s, even in the presence of EGTA and 5,5'-dimethyl-bis-(O-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid as extracellular and intracellular Ca(2+)-chelating agents, respectively, as well as in the presence of the protein-kinase-C inhibitor, H-7. Additionally, genistein, a potent protein-tyrosine kinase inhibitor, was capable of reducing both IgM-stimulated Ca2+ mobilization and p72syk activation in a dose-dependent manner. These results indicate that p72syk is physically associated with the B-cell-antigen receptor, participating in antigen-mediated signal transduction in both a Ca(2+)-independent and protein-kinase-C-independent manners.