gebhart/patrepeval huggingface dataset:
Identification of stromal cell products that interact with pre-B cells. (1996)

Our understanding of lympho-hematopoietic microenvironments is incomplete, and a new cloning strategy was developed to identify molecules that bind to B lineage lymphocyte precursors. A cell sorting procedure was used for initial enrichment of cDNAs from stromal cell mRNA that contained signal sequences and were therefore likely to encode transmembrane or secreted proteins. A second step involved expression of the library as soluble Ig fusion proteins. Finally, pools representing these proteins were screened for the ability to recognize pre-B cells. This approach resulted in the cloning of biglycan, syndecan 4, collagen type I, clusterin, matrix glycoprotein sc1, osteonectin, and one unknown molecule (designated SIM). The full-length cDNA of SIM revealed that it is a type I transmembrane protein, and its intracellular domain has weak homology with myosin heavy chain and related proteins. Staining of established cell lines and freshly isolated hematopoietic cells with the Ig fusion proteins revealed distinct patterns of reactivity and differential dependence on divalent cations. Biglycan-, sc1-, and SIM-Ig fusion proteins selectively increased interleukin 7-dependent proliferation of pre-B cells. Overexpression of the entire SIM protein affected the morphology of 293T cells, while expression of just the extracellular portion was without effect. Thus, a series of stromal cell surface molecules has been identified that interact with blood cell precursors. Three of them promoted the survival and/or proliferation of pre-B cells in culture, and all merit further study in relation to lympho-hematopoiesis.
Risk prediction models for dementia: role of age and cardiometabolic risk factors (2020)

Our analyses of CAIDE, FRS, and FINDRISC show the FRS in midlife to predict dementia as well as the CAIDE risk score, its predictive value being also evident among individuals who did not develop cardiometabolic events. The importance of age in the predictive performance of all three risk scores highlights the need for the development of multivariable risk scores in midlife for primary prevention of dementia.
TEM DETERMINATION OF INCOHERENT TWIN-BOUNDARY STRUCTURE IN L1<sub>2</sub> ORDERED ALLOYS (1988)

The structure of incoherent Σ=3 twin boundaries in the L12 ordered alloy Cu3Au is investigated employing TEM. The boundary planes are found to vary about ten degrees from a {112} plane. Employing the TEM method of α-fringes common diffraction vectors are used for determining the rigid-body translation between the two crystals at the boundary. No dilatation has been found at a (754) incoherent twin boundary within experimental error. Four grain boundary areas having different translations that preserve the density in the boundary are demonstrated, separated from each other by an antiphase boundary on one side of the boundary plane.
Experimental models in the investigation of device-related infections (1993)

There has been an increasing concern with the problem of device-related infections, ever since foreign materials such as metal or plastic began to be used in implant surgery. The prophylaxis and treatment of such infections is difficult to evaluate in clinical studies, because placebo-controlled prophylaxis trials are thought to be unethical, and no single centre has enough patients for comparative treatment studies. For this reason different experimental models have been developed to study aspects of device-related infections. In this review, these infection models are presented. Different applications of the tissue-cage guinea pig model are summarized. This model allows the study of pathogenesis, natural course, prophylaxis, and treatment of device-related infection. In addition, by using this infection model, novel microbiological in-vitro tests could be developed, and questions of biocompatibility analysed.
A Review of Indoor Localization Technologies: towards Navigational Assistance for Topographical Disorientation (2010)

Indoor localization technologies hold promise for many ambient intelligence applications, including in-situ navigational assistance for individuals with wayfinding difficulties. Given that the literature on indoor localization is vast and spans many different disciplines, we conducted a comprehensive review of the dominant technologies. We propose a taxonomy of localization technologies on the basis of the measured physical quantity. In particular, we identified, radio frequency, photonic, sonic and inertial localization technologies as leading solutions in the field. For each selected technology, the fundamental scientific mechanisms for localization are explained, key recent literature appraised and the merits and limitations are discussed. Recommendations are made regarding the creation of context-aware systems that can be used to enhance a user's topographical orientation skills.
Design of a telemedicine system using a mobile telephone (2001)

This paper describes the design of a prototype integrated mobile telemedicine system that is compatible with existing mobile telecommunications networks and upgradable for use with third-generation networks. The system, when fully developed, will enable a doctor to monitor remotely a patient who is free to move around for sports medicine and for emergency situations.
Favorable Outcome in a Newborn With Molybdenum Cofactor Type A Deficiency Treated With cPMP (2012)

Molybdenum cofactor deficiency (MoCD) is a lethal autosomal recessive inborn error of metabolism with devastating neurologic manifestations. Currently, experimental treatment with cyclic pyranopterin monophosphate (cPMP) is available for patients with MoCD type A caused by a mutation in the MOCS-1 gene. Here we report the first case of an infant, prenatally diagnosed with MoCD type A, whom we started on treatment with cPMP 4 hours after birth. The most reliable method to evaluate neurologic functioning in early infancy is to assess the quality of general movements (GMs) and fidgety movements (FMs). After a brief period of seizures and cramped-synchronized GMs on the first day, our patient showed no further clinical signs of neurologic deterioration. Her quality of GMs was normal by the end of the first week. Rapid improvement of GM quality together with normal FMs at 3 months is highly predictive of normal neurologic outcome. We demonstrated that a daily cPMP dose of even 80 μg/kg in the first 12 days reduced the effects of neurodegenerative damage even when seizures and cramped-synchronized GMs were already present. We strongly recommend starting cPMP treatment as soon as possible after birth in infants diagnosed with MoCD type A.
Influence of P<sub>2</sub>O<sub>5</sub>/TeO<sub>2</sub> composition ratio on the physical properties of V<sub>2</sub>O<sub>5</sub>–P<sub>2</sub>O<sub>5</sub>–TeO<sub>2</sub> glasses for lead-free low-temperature sealing (2013)

We examined how the composition ratio of P2O5 to TeO2 affected the physical properties and the structure of the semiconductive vanadate glasses in a low-melting V2O5–P2O5–TeO2 glass system containing 57 mol % V2O5. It was found that increasing the P2O5 content and correspondingly decreasing the TeO2 content raised the glass transition temperature and the deformation temperature as well as the fraction of the reduced V ions ([V4+]/[Vtotal]) and the average interionic distance of the V ions. In addition, the increase in P2O5 content from 7 to 32 mol % lowered the thermal expansion coefficient, volume resistivity, and density by 27, 42, and 14%, respectively, and also lowered the apparent molar volume of O ions and crystallization tendency. Furthermore, the infrared (IR) spectra suggested that the TeO2-enriched glasses had a layered structure similar to crystalline V2O5, whereas the P2O5-enriched glasses had a denser layered structure as a result of the increased packing density of the O ions due to the reduction of the V ions.
The Circulatory Disturbances of the Extremities. Including Gangrene, Vasomotor and Trophic Disorders. (1924)

This volume centers about thrombo-angiitis obliterans, the disease that Buerger has made his own. Nearly a third of the text is devoted to the consideration of this disease. Other diseases are mentioned or described largely from the standpoint of their resemblance to or difference from this one. It is not to be understood that they are imperfectly described. On the contrary, gangrene, arteriosclerosis, Raynaud's disease and other topics are fully discussed. There are also several chapters devoted to the anatomy and physiology of the vessels; and, pertinently, thrombosis is fully considered. The clinical features and pathologic anatomy of thrombo-angiitis obliterans are described with minutest detail, in fact, with such detail as to be bewildering; too much detail, it seems to us. It is a significant commentary on our knowledge of this disease that a close student like Buerger, whose accurate knowledge of the clinical facts and the underlying pathologic anatomy
Temporal and spatial characteristics of tonically active neurons of the primate's striatum (1995)

1. Tonically active neurons (TANs) in the primate striatum develop transient responses to sensory conditioning stimuli during behavioral training in classical conditioning tasks. In this study we examined the temporal characteristics of such TAN responses and mapped the sites of TANs responding to auditory and visual conditioned stimuli in the striatum in macaque monkeys. We further mapped the locations of TANs recorded acutely in the squirrel monkey striatum in relation to the neurochemically distinguished striosome and matrix compartments of the striatum, and made quantitative comparisons between the densities and compartmental distributions of TANs and those of four major types of striatal interneuron identified by histochemical and immunohistochemical staining. 2. We made recordings from 858 TANs at different sites in the striatum in two behaving macaque monkeys at different times during training with auditory (click) and visual (light-emitting diode flash) conditioning stimuli. TANs distributed across large parts of the striatum developed responses to the conditioning stimuli. The responses comprised a decrement of tonic firing (pause) followed by a rebound excitation. Measurements were made of the onsets, offsets, and durations of the pauses of individual TANs and of the interspike intervals (ISIs) of the same cells. 3. The mean duration of the pause responses (268.3 ms) was greater than the mean ISI of the same neurons (181 ms), suggesting that the pause represents an active suppression of TAN firing. The coefficient of variation (CV) for the pause responses was 0.28, compared with a CV of 0.63 for the same cells' ISIs. The population CV for the pauses was 0.16, compared with a population CV of 0.20 for the ISIs. These data, together with temporal analysis of the responses and population histograms, suggest that the pauses became temporally aligned across large parts of the striatum after learning. Analyses of variance (ANOVAs) were carried out to determine whether there were differences in the onset and offset latencies of the pause response or in the durations of the pause responses for TANs at different sites. These analyses suggested that, with rare exceptions, there was no difference in the timing of the TAN responses across large (> 10 mm3) parts of the striatum. 4. Comparisons of TAN responses in different regions of the striatum showed that, for responses to a given modality of conditioned stimulus, there were no significant differences in pause offset times for TANs recorded in the caudate nucleus or putamen, or for TANs recorded in more anterior or more posterior parts of these nuclei.(ABSTRACT TRUNCATED AT 400 WORDS)
DIPLOMAT: compiling prioritized default rules into ordinary logic programs, for e-commerce applications (1999)

Rules promise to be widely useful in Internet electronic commerce. Declarative prioritized default rule knowledge representations offer the advantage of handling conflicts that arise in updating rule sets, but have as yet had little practical deployment. DIPLOMAT is a Java library that embodies a new approach to the implementation of such prioritized default rules: to compile them into ordinary logic programs (LP's) cf. pure Prolog. We apply the approach to a newly generalized version of courteous LP's, a semantically attractive and computationally tractable form of prioritized default rules. Compilation enables courteous LP's functionality to be added modularly to ordinary LP rule engines, via a preprocessor, with tractable computational overhead. This takes a long step towards actual deployment of prioritized-default knowledge representation in commercially fielded technology and applications.We give in the demo storyboard an automated example e-commerce application scenario: inferencing in a 70-rule courteous LP that represents personalized pricing and promotions on a bookstore's Web storefront.
Monolithic integration of In <sub>0.2</sub> Ga <sub>0.8</sub> Asvertical-cavity surface-emitting lasers with resonance-enhanced quantum well photodetectors (1996)

Vertical-cavity surface-emitting lasers (VCSELs) have been monolithically integrated with resonance-enhanced photo-detectors (REPDs) using a single epilayer design, to produce a simple array of sources and detectors for optical interconnect applications. The detectors, which contain a three quantum well InGaAs absorption region, achieve quantum efficiencies as high as 85%, and the VCSELs achieved threshold current densities as low as 850 A/cm2 and differential quantum efficiencies as high as 50%.
Digital model-driven retail supply chain management (2019)

The purpose of this thesis is to increase the understanding of how matching of digital models of products and customers can be used to shift the performance frontier in retail supply chains. This thesis puts forward the matching of digital models as an operational practice used by retail supply chains. Digital product models are digital descriptions of available products on the market and they contain information about the products' characteristics. Digital customer models are digital descriptions of customers and contain customer characteristics and preferences. This thesis concerns product recommendations based on matching of digital product and customer models. This thesis conceptualizes the operational practice of matching digital models of products and customers (Paper I), identifies potential supply chain outcomes by introducing the operational practice in retail supply chains (Paper II), and evaluates mechanisms driving the outcomes in two retail supply chains (Paper III). Exploratory design science research is used to conceptualize the operational practice, and case studies and a case survey are used to empirically evaluate supply chain outcomes and mechanisms that drive them.Findings show how the operational practice moves the performance frontier by improving market mediation performance in retail supply chains, particularly through improved delivery performance and production cost performance. The findings imply that delivery performance and cost performance can be achieved without a trade-off between the two.The practical contribution of this thesis is that the findings help companies understand how their profiles match the operational practice and gear them to achieve the outcomes. The thesis demonstrates how the operational practice would function in real-life and studies how existing similar practices produce the outcomes, which yields insight into hands-on knowledge that can be used by the companies. The thesis develops a maturity model, describing three maturity levels of the operational practice. Companies can map their current status and desirable to-be status in the model and advance in level. The thesis contributes to theory by increasing the solution space for combining efficiency and responsiveness in retail supply chains by bypassing the trade-off between production efficiency and delivery performance through the use of new matching technology. Matching technology enables the operational practice to more fully utilize the existing product variety in already manufactured product supply to move the performance frontier in retail supply chains.
Optical switching mechanisms in type IIa diamond (1986)

The nanosecond optoelectronic switching characteristics of type IIa diamond illuminated by pulsed UV radiation from an excimer laser at λ=193 nm are reported. With sputtered titanium contacts, certain electro-optical conditions produce a secondary current peak which follows the primary photocurrent pulse. When the bias voltage is increased further (with the laser excitation intensity being kept constant), the primary and secondary current pulses merge together, and their combined peak value is observed to have a supralinear increase with respect to bias voltage. The threshold voltages for secondary pulse formation are also shown to decrease with respect to increasing laser excitation intensities. Secondary current pulse formation and decay are shown to be consistent with a model of space-charge-assisted Fowler–Nordheim electron tunneling across the reversed-biased negative Ti/C electrode.
Morphogenesis in dormant embryonic shoots of <i>Picea abies</i>: Influence of the crown and cold treatment (1983)

Retention of the crown, a plate of homogeneously thickened collenchymatous cells at the base of the embryonic shoot of Picea abies (L.) Karst., has marked effects on the induction of adventitious buds from the needle primordia. These effects were observed on embryonic shoots of three clones which were cold‐treated at 4 ± 1°C for nil, two, four and six months; and then excised either with or without the crown, before subculturing either directly on a medium lacking plant growth regulators or after application of 125 μM benzyladenine (BA) as a 3‐h pulse. Embryonic shoots retaining the crown and treated with BA responded reproducibly better than those lacking it. This was true both for the number of shoots that produced adventitious buds and for the numbers of adventitious buds per shoot. Differentiation of as many as five adventitious buds in a single needle primordium was observed, with development occurring nearly twice as early (7 as compared with 12 weeks) in the presence as in the absence of the crown. The response decreased progressively with increasing exposure to cold treatment. A number of anatomical changes occurred during culture in vitro. After 3 to 4 weeks a band of sclerenchymatous cells commenced differentiation at the centre of the crown. In embryonic shoots without the crown, a tissue which was identified as a wound periderm formed at the excision surface. Vascular unions were observed between the tissues of the newly — formed shoots induced from the needle primordia and those of the original shoot explants.
Superficial spreading and nodular melanoma are distinct biological entities (2011)

The classification of melanoma subtypes into prognostically relevant and therapeutically insightful categories has been a challenge since the first description of melanoma in the 1800s. One limitation has been the assumption that the two most common histological subtypes of melanoma, superficial spreading and nodular, evolve according to a linear model of progression, as malignant melanocytes spread radially and then invade vertically. However, recent clinical, pathological, and molecular data indicate that these two histological subtypes might evolve as distinct entities. Here, we review the published data that support distinct molecular characterization of superficial spreading and nodular melanoma, the clinical significance of this distinction including prognostic relevance and the therapeutic implications.
Proposed evaluation method concerning numerical display device visibility (2002)

The authors describe the clarity and legibility of characters on numerical display devices of the luminous type (light-emitting diode, vacuum fluorescent display, and liquid crystal display of the negative type, which is regarded as being of the luminous type) and nonluminous type (liquid crystal display of the positive type). The brightness, luminance contrast, indication numerals, illuminance on the display device faceplate surface, and angle of the inclination of the display device faceplate, affecting both the clarity and legibility of the characters, were measured to make the cross-correlation of these parameters clear from the viewpoints of both the clarity and legibility of the characters. Significant differences were observed between the illuminances and indication numeral when the clarity and legibility of the characters were measured on the luminous display devices. Based on the measurements described, a method for testing the visibility of the characters on the numerical display devices is proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Switching sliding-mode control for nonlinear processes (2003)

The paper is concerned with the simple design method of switching control for nonlinear processes. The proposed method approximates nonlinear processes by the set of plural linear systems the dynamic characteristics of which is switched sectionally, and performs state estimation using multiple observers. Using a performance index that consists of output errors, a supervisor performs switching of a suitable model and controller.
Study of interdiffusion in Pd/Cu multilayered films by Auger depth profiling (1994)

In thin films, diffusion phenomena play an important role for the growth process, and in the understanding of the mechanical, electrical and magnetic properties. The change in the concentration profile due to the interdiffusion by annealing was investigated using Auger electron spectroscopy depth-profiling technique on Pd/Cu multilayered films. It was observed that the initial concentration distributions, which were almost rectangular in the unheated samples, were changed into sinusoidal ones in the annealed films at various temperatures. The concentration-independent interdiffusion coefficients were calculated from the amplitudes of sinusoidal distributions. The activation energy was determined to be 1.66±0.23 eV from the Arrhenius plot. The concentration-dependent interdiffusivity at 150 °C was also estimated using Boltzmann–Matano method.
A Selected Public Health Bibliography (1928)

A Selected Public Health Bibliography Raymond S. Patterson CopyRight https://doi.org/10.2105/AJPH.18.5.696 Published Online: August 29, 2011
Disruption of OTC promoter-enhancer interaction in a patient with symptoms of ornithine carbamoyltransferase deficiency (2010)

In a female patient with signs of ornithine carbamoyltransferase deficiency (OTCD), the only variation found was a heterozygous single nucleotide substitution c.-366A>G. Determination of transcription start sites of human OTC 95, 119 and 169 bp upstream of the initiation codon located the variation upstream of the 5'-untranslated region. We predicted the human promoter and enhancer elements from homology with rat and mouse, performed function analysis of both regulatory regions and assessed the impact of the promoter variation in functional studies using dual luciferase reporter assay. Our data indicate that: (i) Full transcriptional activity of human OTC promoter depends on an upstream enhancer, as do the rodent promoters. (ii) The promoter variation c.-366A>G does not affect the function of the promoter alone but it disrupts the interaction of the promoter with the enhancer. (iii) The promoter-enhancer interaction contributes to tissue specific expression of OTC in the liver. We conclude that mutations in the regulatory regions of OTC can lead to OTCD and should be included in genetic testing.