gebhart/patrepeval huggingface dataset:
Psychological profile of children with Noonan syndrome (2005)

A cohort of 48 children with Noonan syndrome, with a mean age of 9 years 10 months (SD 3y 7mo; 28 males, 20 females), was recruited from a national study. Children were assessed using the Wechsler Intelligence Scales and Test of Motor Impairment-Revised (TOMI-R). The Piers-Harris Self-evaluation Questionnaire was also completed in a subgroup of age-appropriate children. Children's parents and teachers completed the Rutter A and B scales to assess of the degree of behavioural and emotional problems respectively. Mean Full-scale IQ score was 84, and one-quarter of the participants had learning disabilities. Verbal IQ tended to be slightly lower than Performance IQ. About half of the group showed evidence of mild to moderate impairment, confirming the impression of 'clumsiness/developmental coordination disorder' on the TOMI-R. Level of self-esteem, as determined by the Piers-Harris Questionnaire, was comparable to that of a standardized population. This research has identified some characteristic psychological features in Noonan syndrome. However, a specific behavioural phenotype could not be identified.
Human TOLLIP Regulates TLR2 and TLR4 Signaling and Its Polymorphisms Are Associated with Susceptibility to Tuberculosis (2012)

Tuberculosis, one of the leading causes of death worldwide, stimulates inflammatory responses with beneficial and pathologic consequences. The regulation and nature of an optimal inflammatory response to Mycobacterium tuberculosis remains poorly understood in humans. Insight into mechanisms of negative regulation of the TLR-mediated innate immune response to M. tuberculosis could provide significant breakthroughs in the design of new vaccines and drugs. We hypothesized that TOLLIP and its common variants negatively regulate TLR signaling in human monocytes and are associated with susceptibility to tuberculosis. Using short hairpin RNA knockdown of TOLLIP in peripheral blood human monocytes, we found that TOLLIP suppresses TNF and IL-6 production after stimulation with TLR2 and TLR4 ligands. In contrast, secretion of the anti-inflammatory cytokine IL-10 was induced by TOLLIP. We also discovered two common polymorphisms that are associated with either decreased levels of mRNA expression (rs3750920) or increased IL-6 production (rs5743899) in a sample of 56 healthy volunteers. Furthermore, in a case-population study in Vietnam with 760 cord blood samples and 671 TB case patients, we found that SNPs rs3750920 and rs5743899 were associated with susceptibility to tuberculosis (p = 7.03 × 10(-16) and 6.97 × 10(-7), respectively). These data demonstrate that TOLLIP has an anti-inflammatory effect on TLR signaling in humans and that TOLLIP deficiency is associated with an increased risk of tuberculosis. To our knowledge, these data also show the first associations of TOLLIP polymorphisms with any infectious disease. These data also implicate an unexpected mechanism of negative regulation of TLR signaling in human tuberculosis pathogenesis.
Identification of a selective glucocorticoid receptor modulator that prevents both diet‐induced obesity and inflammation (2016)

C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation. These data suggest that selective GR modulation may be a viable strategy for the reduction of diet-induced obesity and inflammation.
Alginate Lyases: Sources, Mechanism of Activity and Potencial Application (2013)

Alginate lyases are group of enzymes which catalyze depolymerization of alginate into oligosaccharides. Alginate lyase have been widely used in many applications such as in production of bioactive oligosaccharides, control of polysaccharide rheological properties, and polysaccharide structure analysis. The products of alginate lyase, polysaccharide structure analysis, alginate oligosaccharides (AOS) have many biological activities including act as prebiotics, immune modulator, anticoagulation, antioxidant, anticancer, growth promoting activities, promote production of antibiotics and ethanol. In relation to the importance of alginate lyases, their potential aplications and prospect in development of new bioactive products, we present review of the enzymes, sources, mechanism of activity and potential applications. This paper also discussed some new biological engineering in alginate lyase production.
ATE digital testing using a programmable microsequencer architecture (2002)

In the past, the digital testing of an aircraft's complex line replaceable units (LRUs) on large automatic test equipment (ATE) was handled by designing a special set of interface boards. As more and different LRUs were added to the aircraft, the test stations began to run out of room in the interface test adapter (ITA) patch panel. The solution was to design an interface board that uses a microcoded bit-slice architecture. This allowed many parallel and serial test requirements to be met with only a new microprogram thereby eliminating the need to design a new interface board when new requirements were added to the test station. It also allowed making changes easier. Putting multiple copies of a design into a test station allowed it to meet different requirements simultaneously. This microprogrammable architecture has been designed into the various ATE at the General Dynamics Electronics Division. The digital interface boards support over 300 different microprograms on over 50 LRUs on four different aircraft (F-16, B-1B, C-17, and C-5).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Chemical equilibrium calculations of tungsten–halogen systems (1983)

The performance of the compound bromotrifluoromethane (CBrF3) as a tungsten–halogen bulb fill gas was evaluated theoretically by chemical equilibrium calculations. It was found to be an ideal fill gas in terms of maintaining clear bulb walls and redepositing evaporated tungsten on hot spots in the filament. The calculations were done at different CBrF3 and water concentrations. The compounds most responsible for tungsten transport were identified; fluorine compounds of tungsten dominate over bromine compounds. Finally, CBrF3 is compared to other possible fill gases such as CBr2F2, CBr3F, CBr4, and also HBr, since HBr is presently used commercially.
Molecular Cloning of a cDNA Encoding an Amphid-Secreted Putative Avirulence Protein from the Root-Knot Nematode<i>Meloidogyne incognita</i> (2001)

Amplified fragment length polymorphism fingerprinting of three pairs of Meloidogyne incognita near-isogenic lines (NILs) was used to identify markers differential between nematode genotypes avirulent or virulent against the tomato Mi resistance gene. One of these sequences, present only in the avirulent lines, was used as a probe to screen a cDNA library from second-stage juveniles (J2s) and allowed cloning of a cDNA encoding a secretory protein. The putative full-length cDNA, named map-1, encoded a 458 amino acid (aa) protein containing a predictive N-terminal secretion signal peptide. The MAP-1 sequence did not show any significant similarity to proteins deposited in databases. The internal part of the protein, however, was characterized by highly conserved repetitive motives of 58 or 13 aa. Reverse transcription polymerase chain reaction (RT-PCR) experiments confirmed that map-1 expression was different between avirulent and virulent NILs. In PCR reactions, map-1-related sequences were amplified only in nematode populations belonging to the three species against which the Mi gene confers resistance: M. arenaria, M. incognita, and M. javanica. Polyclonal antibodies raised against a synthetic peptide deduced from the MAP-1 sequence strongly labeled J2 amphidial secretions in immunofluorescence microscopy assays, suggesting that MAP-1 may be involved in the early steps of recognition between (resistant) plants and (avirulent) nematodes.
P2‐198: Chemical manipulation of Hsp70 activity regulates tau processing (2009)

The microtubule associated protein tau abnormally accumulates in a group of neurodegenerative diseases collectively termed tauopathies. Post-translational modifications of tau subvert its removal by the cellular clearance machinery, allowing it to form filamentous pathogenic tangles. Heat shock protein 90 (Hsp90), a chaperone that shepherds tau as a client protein, possesses ATPase activity, which, when manipulated, can change the fate of tau, either preventing or promoting clearance. Here, we speculated that Hsp70, a chaperone acting proximally to Hsp90 in the protein folding cycle, could also be modified pharmacologically to impact tau processing. We used a newly developed high-throughput chemical screen to accomplish this. We identified both inhibitors and activators of Hsp70 ATPase activity. Treatment of cell models with these Hsp70 inhibitors led to a rapid increase in tau ubiquitination and proteasome-dependent degradation, while activators led to tau accumulation. Genetic manipulation of Hsp70 altered drug efficacy. Tau levels were rapidly reduced in mouse brain tissue from both non-transgenic mice and mice over-expressing mutant human tau. Our results suggest that manipulation of endogenous basal Hsp70 may be an important therapeutic strategy for tauopathies and perhaps other neurodegenerative disorders involving intrinsically unfolded protein aggregation.
A 14.4nW 122KHz dual-phase current-mode relaxation oscillator for near-zero-power sensors (2015)

This paper presents a novel ultra-low-power dual-phase current-mode relaxation oscillator, which produces a 122 kHz digital clock and has total power consumption of 14.4 nW at 0.6 V. Its frequency dependence is 327 ppm/°C over a temperature range of -20° C to 100° C, and its supply voltage coefficient is ±3.0%/V from 0.6 V to 1.8 V. The proposed oscillator is fabricated in 0.18 μm CMOS technology and occupies 0.03 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . At room temperature it achieves a figure of merit of 120 pW/kHz, making it one of the most efficient relaxation oscillators reported to date.
CD4 T-Cell Immunotherapy for Chronic Viral Infections and Cancer (2013)

During chronic infections and cancer, T cells progressively lose function and become exhausted. However, effective T-cell responses are necessary to ultimately control viral infections and tumors. Hence, strategies that either restore endogenous immune responses or provide functional T cells by adoptive immunotherapy need to be explored. CD8 T cells play a prominent role in viral infections, as well as cancer, but CD4 T cells are necessary to support CD8 T-cell function. In addition, CD4 T cells exert direct effector functions, induce optimal B-cell responses and orchestrate innate immunity. Therefore, we propose that adoptive transfer strategies should exploit CD4 T cells alone or in combination with CD8 T cells, for the treatment of chronic infections and cancer. Furthermore, since adoptively transferred cells are subject to exhaustion, combining adoptive transfer therapy with immunotherapies that inhibit T-cell exhaustion should maximize the longevity and success rate of responses.
Elekta Precise Table characteristics of IGRT remote table positioning (2008)

Our results show a linear relation between linac control system read out and measured position. Effects of imperfect calibration are seen. A reproducibility within a standard deviation of 0.22 mm in lateral and longitudinal directions while within 0.43 mm in vertical direction has been observed. The usage of XVI requires knowledge of the characteristics of remote table positioning. It is our opinion that the method presented meets the requirements in high precision IGRT.
Far-infrared bandpass filters from cross-shaped grids (1981)

The optical transmission characteristics of electroformed metal grids with inductive and capacitive cross patterns have been investigated in the far-infrared spectral region. The transmission characteristics of one-and two-grid devices are represented by transmission line theory parameters. Results are used to suggest construction guidelines for two-grid bandpass filters.
PP.LB02.24 (2015)

Objective: It is known that macrophage infiltrates in the vasculature after vascular injury and contributes to neointima formation, but the functional molecules responsible for regulating its infiltration in neointimal lesion are largely unknown. Design and method: Thus, this study investigated the role of 5-LO in macrophage infiltration and neointima formation after wire injury in femoral artery of mice. Results: Neointima formation with subsequent reduction in blood flow in femoral artery was started at 2 and 3 weeks after wire injury to the femoral artery. At 4 weeks after wire injury, macrophage infiltration in neointimal lesion was markedly increased. We stained endothelial layer with anti-CD11b antibody as a marker for the presence of macrophages and determined macrophages adhered to endothelial surface surrounding the orifice of femoral artery. The number of macrophages adhering to the femoral artery endothelium was significantly decreased in 5-LO knockout mice relative to control mice. Considering the facts that macrophage infiltration was started at later phase of neointima formation, it was suggested that chemotactic factors secreted from neointimal lesion might be involved in recruitment of macrophages into neointimal lesion. In mice pretreated with a 5-LO inhibitor, MK886 (1 mg/kg and 10 mg/kg) or depleted of 5-LO, wire injury-induced neointima formation with subsequent decrease in blood flow in injured artery was markedly attenuated, suggesting a potential involvement of 5-LO in neointima formation after vascular injury through inhibitory action of macrophage infiltration. Conclusions: Based on these results, it is indicated that 5-LO is viewed as a novel target for the prevention and treatment of restenosis after angioplasty or stent implantation in stenotic arteries.
Workflow-oriented prototyping for the development of interactive software (2002)

Nowadays interactive systems cannot be developed in isolation from workflows and the application domains they are embedded in. Unfortunately, a conceptual gap exists between design representations for interactive systems and workflow specifications. This gap leads to a situation in which it can be checked in a very late stage of development whether an interactive system actually fits into a particular workflow or not. If not, redesign is required and the development costs may be increased dramatically. In order to avoid this worst case, the authors introduce a framework and environment that allows the refinement of workflows to system functions at an implementation-independent layer. In addition, TADEUS (Task Analysis/Design/End User Systems) supports workflow driven prototyping. Developing interactive systems this way not only removes the conceptual gap between workflow models and user interface design representations, but also provides early feedback for the developers through the interpretation of the design representations.
Low-voltage CMOS analog switch for high precision sample-and-hold circuit (2002)

This paper presents a sample-and-hold circuit based on a novel implementation of the bootstrapped low-voltage analog CMOS switch. The heart of this circuit is a new low-voltage and low-stress CMOS clock voltage doubler. Through the use of a dummy switch, the charge injection induced by the bootstrapped switch is greatly reduced resulting in improved sample-and-hold accuracy. Simulation results using a 0.18 /spl mu/m digital CMOS process show that a resolution greater than 16 bits can be obtained with a 1.65 V supply voltage. Operation is also possible for supply voltages close to transistor threshold (e.g., 0.5 V).
Hematological profile of the euthymic hairless guinea pig following sulfur mustard vesicant exposure (1995)

Sulfur mustard (HD) is a potent vesicating agent of military importance, with known radiomimetic properties. The euthymic hairless guinea pig (EHGP) (Cavia porcellus) is emerging as the animal model of choice for cutaneous HD study. With elucidation of the systemic effects, we may better utilize this animal for all HD toxicity work. To this end, studies were conducted to determine the definitive median lethal dose (MLD) of subcutaneously applied sulfur mustard (HD) in the EHGP, and to correlate the induced hematological changes. Eight groups of two animals each were dosed at 0.3 log intervals from an extrapolated expected dose, deriving a tentative mean around which five groups of six animals each were dosed at 0.1 log intervals, resulting in a definitive MLD of 48.17 mg kg(-1). Sulfur mustard was then administered to seven groups of six animals each at a dose of 30 mg kg(-1) and hematology performed. Significant leukocyte count suppression was found to occur on days 4, 5 and 6, following a leukocyte elevation on day 1 after exposure. Serum potassium levels were found to be elevated all 7 days after HD exposure. Establishing the MLD for subcutaneously applied HD and the pattern of induced leukocyte suppression allows for more definitive evaluation of successful toxicity counter-measures.
Effective gettering of oxygen by high dose, high energy boron buried layers (2002)

We examined the gettering of oxygen by high energy implanted boron in the 3/spl times/10 cm to 2/spl times/10/sup 15/ cm/sup -2/ dose range. Boron implants getter oxygen effectively by enhancing the nucleation rate of oxygen precipitates at the buried layer peak depth. This process occurs over a wide range of annealing conditions. Vacancies resulting from the implant also enhance the nucleation rate, this effect is slight and limited to low anneal temperatures. Oxygen is gettered only to precipitates, no peaks were observed in pre-denuded wafers. Buried layers are effective at reducing surface oxygen levels in undenuded Czochralski silicon. A 1.5 MeV, 1/spl times/10/sup 15/ cm/sup -2/ boron implant followed by a 1 hour furnace anneal reduces the oxygen level In undenuded silicon down to <2/spl times/10/sup 17/ cm/sup -3/. This level is typical of denuded silicon, suggesting that buried layers can be a low cost and reduced cycle time alternative to denuded bulk wafers.
ZoomBoard (2013)

The proliferation of touchscreen devices has made soft keyboards a routine part of life. However, ultra-small computing platforms like the Sony SmartWatch and Apple iPod Nano lack a means of text entry. This limits their potential, despite the fact they are quite capable computers. In this work, we present a soft keyboard interaction technique called ZoomBoard that enables text entry on ultra-small devices. Our approach uses iterative zooming to enlarge otherwise impossibly tiny keys to comfortable size. We based our design on a QWERTY layout, so that it is immediately familiar to users and leverages existing skill. As the ultimate test, we ran a text entry experiment on a keyboard measuring just 16 x 6mm - smaller than a US penny. After eight practice trials, users achieved an average of 9.3 words per minute, with accuracy comparable to a full-sized physical keyboard. This compares favorably to existing mobile text input methods.
Active Fuel Management™ Technology: Hardware Development on a 2007 GM 3.9L V-6 OHV SI Engine (2007)

<div class="htmlview paragraph">In the North American automotive market, cylinder deactivation by means of engine valve deactivation is becoming a significant enabler in reducing the Brake Specific Fuel Consumption (BSFC) of large displacement engines. This allows for the continued market competitiveness of large displacement spark ignition (SI) engines that provide exceptional performance with reduced fuel consumption. As an alternative to a major engine redesign, the Active Fuel Management™ (AFM™) system is a lower cost and effective technology that provides improved fuel economy during part-load conditions. Cylinder deactivation is made possible by utilizing innovative new base engine hardware in conjunction with an advanced control system. In the GM 3.9L V-6 Over Head Valve (OHV) engine, the standard hydraulic roller lifters on the engine's right bank are replaced with deactivating hydraulic roller lifters and a manifold assembly of oil control solenoids. This paper presents the engine hardware modifications and packaging challenges of adapting the AFM™ system to the 3.9L V-6 engine. Finally, fuel economy results for the 2007 3.9L V-6 engine equipped with AFM™ are compared to the fuel economy of its 2006 non-AFM™ predecessor.</div>
Nanoengineered Additives for Active Coatings (2007)

Abstract : Novel additives for polymeric coatings have been developed based on modified hyperbranched polymers. The additives are polyfunctional and have been prepared to spontaneously segregate to the surface of the polymer in which they are dispersed. They ave been used to install active sites in polymeric films, with little or no change in the formulation, bulk properties, or application of the coating.
Web-Based Content Management System for Equipment Information (2012)

Summary form only given. Our lab has developed a database driven content management system for lab members to obtain up to date information on the status and availability of tools from any web browser. The system displays whether a tool is up, down or in a caution state. It provides a calendar of upcoming reservations-either in-browser or as an ical file. Tools can be pinpointed on a map. Tool specific downloads can be stored in a versionable file repository with tiered access to control visibility to each of 3 groups: lab staff, lab members and the general public. Administration views and controls are available to lab staff when logged in. The system can be configured to use OpenCoral as the data backend. By installing the JasperServer reporting engine, a number of reports covering lab usage, equipment metrics and repair history can also be hosted and linked to the same set of information. This presentation will demonstrate how our web system is accessed by first going through the typical experience of a lab member, from authentication to looking up tool information, including the availability of reservation slots and any problems that have been reported on the tool. Then the user interface that is used by administrators for updating information and uploading files will be shown. The second portion of the demonstration will show the software components that make up the system and give an overview of how to install the application onto an existing web server. The software is based on a typical LAMP (Linux, Apache, MySQL and PHP) stack with LDAP authentication on the backend. Database storage can also use PostgreSQL. The JasperReports reporting engine is used for displaying reports. I will discuss the various caveats that need to be considered when setting up and connecting these systems, as well as plans for future improvements.
N,N’-Diferuloyl-putrescine (DFP)과 그 유도체의 합성 및 항산화 활성 (2015)

N,N’-diferuloyl-putrescine (DFP)은 회화나무 잎 등 식물계에 함유되어 있는 화합물로 피부 미백활성 및 항산화 활성등이 있는 것으로 보고되고 있다. 본 연구에서는 식물계에서 미량 존재하는 DFP를 기능성 화장품 원료로 사용할 목적 으로 다량 확보하고자 DFP 및 그 유도체(DFP-D)를 합성하였다. 합성한 DFP 및 DFP-D에 대한 항산화 활성을 DPPH법, 루미놀 발광법을 통하여 확인하였으며, 추가적으로 1O2에 대한 세포보호 효과를 평가하였다. 1,1-Diphenyl-2- picrylhydrazyl (DPPH) 라디칼 소거활성(FSC50)은 DFP가 61.25 ± 2.25 μM, DFP-D는 12.92 ± 0.72 μM을 나타냈으며, 루미놀 발광법을 이용한 Fe3+-EDTA/H2O2계에 있어서의 총항산화능(OSC50)에서 DFP와 DFP-D는 비교물질로 사용한 L-ascorbic acid보다 각각 2배(1.84 ± 0.12 μM) 및 13배(0.174 ± 0.01 μM) 더 큰 총항산화능을 나타내었다. 피부 광노화에 있어서 핵심 역할을 하는 활성산소인 1O2으로 유도된 세포 손상에 있어서 50 μM의 DFP-D의 세포 보호능(τ50 = 80.2 min)은 (+)-α-tocopherol (τ50 = 43.6 min)보다 약 2배 정도 더 우수한 세포보호 효과를 나타내었다. 이상의 결과들을 통해 합성된 DFP 및 유도체 DFP-D의 강력한 항산화 활성은 기능성 화장품 원료로 사용하여 화장품 산업에 응용 가능성이 있음을 시사한다.