gebhart/patrepeval huggingface dataset:
Correlation between refractory periods and activation-recovery intervals from electrograms: effects of rate and adrenergic interventions. (1985)

Unipolar electrograms from ventricular epicardium in dogs were analyzed for the timing of local excitation and repolarization with computer assistance. The most rapid decrease in voltage in the QRS (dV/dt min) was used to determine local excitation time, and the maximum rate of voltage increase (dV/dt max) near the peak of the T wave was used to time local repolarization. The difference between dV/dt min and dV/dt max, the activation-recovery interval, is theoretically related to the net effect of the durations of the action potentials at that site. Paired data for refractory periods and activation-recovery intervals obtained from the same electrodes during fixed activation orders were obtained before and during repolarization changes induced by changes in cycle length, infusion of norepinephrine, and cardiac sympathetic nerve stimulation. Correlation coefficients were close to 1.00 and standard errors were 2.0 to 4.3 msec for changes at individual sites. Pooling of data from multiple sites increased standard errors and reduced correlation coefficients. Results provide quantification of errors in the use of unipolar electrograms to time local repolarization changes induced by variations in rate and adrenergic tone. They should increase the practical usefulness of the unipolar electrogram as a tool for assessing the time course and spatial distribution of repolarization changes.
Adeno‐associated virus–mediated osteoprotegerin gene transfer protects against particulate polyethylene–induced osteolysis in a murine model (2002)

OPG gene transfer mediated by rAAV effectively protects against particulate polyethylene-induced bone resorption in this experimental model. Data suggest that gene transfer using rAAV-OPG may be a feasible and effective therapeutic candidate to treat or prevent wear debris-associated osteolysis and aseptic loosening.
Electromechanical Coupling Mechanism and Control Strategy for In-Wheel-Motor-Driven Electric Vehicles (2018)

This paper presents a control methodology for solving the vibration issues emerged in in-wheel motor electric vehicles (IWM-EVs). Unlike existing techniques and methods, the proposed investigation focuses on the electromechanical coupling effects between the subsystems in IWM-EV, which were considered as another negative effects bought by power integration. To this aim, an integrated model which describes the dynamic coupling process between electromagnetic excitation in motor and transient dynamics in vehicle is established and developed. The characteristics of the electromechanically motivated harassment are discussed and its coupling mechanism is analyzed. The key factors are extracted and adopted as the feedback signals in the design of control methods. The effectiveness verification is conducted within numerous practical scenario of vehicle dynamics. Theoretical analysis and simulation results reveal that the proposed approaches can prevent further enlargement of air-gap deformation and unbalanced electromagnetic excitation by cutting off the electromagnetic force outputting periodically, which are benefitted to attenuate the negative issues arisen by electromechanical coupling in IWM-EV. In addition, a more balanced outcome in vehicle dynamics is achieved by the independent-phase chopping method with a less side effect on output torque and speed tracking ability.
RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia (2000)

The SH2 domain-containing tyrosine phosphatase PTPN6 (SHP-1, PTP1C, HCP) is a 68 kDa cytoplasmic protein primarily expressed in hematopoietic cell development, proliferation and receptor-mediated mitogenic signaling pathways. By means of direct dephosphorylation, it down-regulates a broad spectrum of growth-promoting receptors, including the Kit tyrosine kinase, activated to elicit a prominent cascade of intracellular events by stem cell factor binding. The pivotal contribution of PTPN6 in modulating myeloid cell signaling has been revealed by the finding that shp-1 mutation is responsible for the overexpansion and inappropriate activation of myelomonocytic populations in motheaten (me/me) and motheaten viable (me(v)/me(v)) mice. Association of PTPN6 with c-Kit and negative modulation of the myeloid leukocyte signal transduction pathways prompted us to examine the expression of the protein tyrosine phosphatase PTPN6 gene in CD34(+)/CD117(+) blasts from acute myeloid leukemia patients. We identified and cloned cDNAs representing novel PTPN6 mRNA species, derived from aberrant splicing within the N-SH2 domain leading to retention of intron 3. Sequence analysis of cDNA clones revealed multiple A-->G editing conversions. The editing of PTPN6 mRNA mainly occurred as an A-->G conversion of A(7866), which represents the putative branch site in IVS3 of PTPN6 mRNA. Evidence that editing of A(7866) abrogates splicing has been obtained in vitro by using an edited clone and its backward clone generated by site-directed mutagenesis. The level of the aberrant intron-retaining splice variant, evaluated by semi-quantitative RT-PCR, was lower in CD117(+)-AML bone marrow mononuclear cells at remission than at diagnosis, suggesting the involvement of post-transcriptional PTPN6 processing in leukemogenesis.
Performance comparison of intrusive and non-intrusive instrumental quality measures for enhanced speech (2016)

Instrumental quality prediction of speech processed by enhancement algorithms has become crucial with the proliferation of far-field speech applications. To date, while several instrumental measures have been proposed and standardized, their performance under a wide range of acoustic conditions and enhancement algorithms is still unknown. This paper aims to fill this gap. Specifically, the performance of eleven instrumental measures are compared; four are non-intrusive measures, i.e. not requiring a clean reference signal, and seven intrusive. Simulated and recorded speech under four different acoustic conditions involving varying levels of reverberation and noise are explored, as well as processed by three single- and multi-channel enhancement algorithms. Experimental results show that a recently developed non-intrusive measure called SRMR <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">norm</sub> outperforms all other considered measures in terms of overall quality prediction. The well-known PESQ measure, in turn, showed to better predict the perceived amount of reverberation, followed by SRMR <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">norm</sub> . These results are promising, as the latter measure does not require access to a clean reference signal, thus has the potential to be used for enhancement algorithm optimization in real-time.
Champion-challenger based predictive model selection (2007)

The selection of appropriate data mining predictive models is a challenging task. While it is easy to evaluate the model based on the historical data at a given point in time, using confusion matrix and misclassification rate, it is not very easy to ensure that the selected model upon deployment stays the most effective one as newer data comes in. Here we will address the issue of how to continually strive for the best model even after a predictive model is deployed for production use. In the champion-challenger based model selection paradigm, the historical data is used for creating the best or the champion predictive model using criteria like misclassification rate for a given cost matrix. Apart from the champion models, a number of other models are selected which are not as good as the champion model in predictive accuracy using same data. These models are termed as challengers to the current champion model. These models may differ from the champion model in the underlying predictive algorithm, algorithm tuning parameters or in use of model attributes. The predictive modeling starts with the conventional processes such as identifying the business problem that warrants the need for predictive modeling, finding the significant attributes for modeling, data quality analysis, followed by the actual modeling building and evaluation of the models. However, the emphasis is not at finding just the top or the champion model but to find the other models that are close in terms of model performance. The guiding principle here is that the selection of the best predictive model based on the current set of historical data, is not the stamp of approval till eternity. Real world systems that use predictive modeling are complex and dynamic processes and need to incorporate means to capture that. When the champion model is deployed in a production system and is used for predictions, these results are saved in a table. Likewise, the challenger models are also used to score a subset of the data and save the results. The predictions of the challenger models do not impact the real-time predictive use of the system. Based on the time intervals for future predictions, when the future time arrives, the actual results are captured for the same instances of data.
Use of 2,6-diaminopurine in oligonucleotide gene probes (1989)

Conference Article| October 01 1989 Use of 2,6-diaminopurine in oligonucleotide gene probes UTA B. VOSS; UTA B. VOSS *Department of Biochemistry, Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, United Kingdom Search for other works by this author on: This Site PubMed Google Scholar ANDRE CHOLLET; ANDRE CHOLLET †Glaxo Institute for Molecular Biology, Route des Acacias 46, 1211 Geneva 24, Switzerland Search for other works by this author on: This Site PubMed Google Scholar ALAN D. B. MALCOLM ALAN D. B. MALCOLM *Department of Biochemistry, Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, United Kingdom Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (5): 913. https://doi.org/10.1042/bst0170913 Article history Received: April 12 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation UTA B. VOSS, ANDRE CHOLLET, ALAN D. B. MALCOLM; Use of 2,6-diaminopurine in oligonucleotide gene probes. Biochem Soc Trans 1 October 1989; 17 (5): 913. doi: https://doi.org/10.1042/bst0170913 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Effects Of A Neuromuscular Dentistry-designed Mouthguard On Muscular Endurance And Anaerobic Power (2009)

A mouthguard is an often overlooked piece of equipment that athletes in many sports are required to wear due to the protective elements. However, recent advances in neuromuscular dentistry have led to the development of a mouthguard touted to also enhance performance through optimal jaw alignment. PURPOSE: To examine the effects of a neuromuscular dentistry-based mouthguard on muscular endurance and anaerobic power and capacity in competitive athletes. METHODS: Anaerobically-trained professional and Division I college athletes (N=22; Mweight = 86.2 + 3.1 kg) participated in this blinded, crossover design study. Subjects were randomly assigned to order of use of either the experimental (EXP) or traditional custom-fit (CON) mouthguards, which were matched for appearance and material. Subjects first completed a fitting session coupled with a familiarization session to control for practice effects on the anaerobic tests. Fitting for EXP involved 60 min of electrical stimulation to produce lower jaw relaxation. Two separate testing sessions, approximately 7 days apart, followed the initial session. During each condition, participants completed three different performance tests: vertical jump (VJ), bench press with a load equal to bodyweight for maximal repetitions (BP), and a 30s Wingate Anaerobic Test (WAnT). Subjects refrained from training for 24 h prior to each testing session. RM ANOVAs were used for statistical analysis. RESULTS: VJ was significantly higher for EXP (EXP = 67.6 + 2.0 cm; CON = 65.3 + 1.8 cm; P =.003). BP repetitions were not significantly different between conditions (EXP = 16.1 + 1.1 reps; CON: 15.8 + 1.2 reps; P =.48). Peak power on the WAnT was significantly greater while wearing EXP (EXP = 11.6 + 0.4 W·kg-1; CON = 11.1 + 0.3 W·kg-1; P =.038). There were no significant differences in average power during the WAnT (EXP = 8.5 + 0.3 W·kg-1; CON = 8.4 + 0.2 W·kg-1; P =.54). CONCLUSIONS: A neuromuscular dentistry-based mouthguard appears to enhance peak power output and performance in explosive, short duration bouts of exercise. However, it does not appear to enhance sustainable power output or muscular endurance. There may be some practical value for athletes in power sports. Funding provided by Pure Power Mouthguard, Inc.
Treatment of Scarring Alopecia in Discoid Variant of Chronic Cutaneous Lupus Erythematosus With Tacrolimus Lotion, 0.3% (2015)

This report is, to our knowledge, the first mention of tacrolimus being used in a lotion formulation to treat DLE lesions, resulting in hair regrowth. Topical tacrolimus lotion, 0.3%, in an alcohol base may be a potential therapeutic option for patients with DLE that is refractory to first-line therapies and who risk late-stage disease with permanent scarring alopecia.
Fe-MCM-41 for Selective Epoxidation of Styrene with Hydrogen Peroxide (2001)

Abstract Fe-MCM-41 prepared by direct hydrothermal synthesis catalyzes the epoxidation of styrene with diluted H2O2. The selectivity to styrene oxide reached 67% at styrene conversion of 17% over the catalyst with Si/Fe ratio of 86, which is better than that obtained over TS-1 or a titanium-incorporated silica.
Logistic regression protects against population structure in genetic association studies (2005)

We conduct an extensive simulation study to compare the merits of several methods for using null (unlinked) markers to protect against false positives due to cryptic substructure in population-based genetic association studies. The more sophisticated “structured association” methods perform well but are computationally demanding and rely on estimating the correct number of subpopulations. The simple and fast “genomic control” approach can lose power in certain scenarios. We find that procedures based on logistic regression that are flexible, computationally fast, and easy to implement also provide good protection against the effects of cryptic substructure, even though they do not explicitly model the population structure.
GPU Visualization and Voxelization of Yarn-Level Cloth (2014)

Most popular methods in cloth rendering rely on volumetric data in order to model complex optical phenomena such as sub-surface scattering. Previous work represents yarns as a sequence of identical but rotated crosssections. While these approaches are able to produce very realistic illumination models, the required volumetric representation is difficult to compute and render, forfeiting any interactive feedback. In this paper, we introduce a method based on the GPU for simultaneous visualization and voxelization, suitable for both interactive and offline rendering. Our method can interactively voxelize millions of polygons into a 3D texture, generating a volume with sub-voxel accuracy which is suitable even for high-density weaving such as linen.
Improved Survival of HIV-1-Infected Patients with Progressive Multifocal Leukoencephalopathy Receiving Early 5-Drug Combination Antiretroviral Therapy (2011)

ClinicalTrials.gov NCT00120367.
Vidian Canal Types and Dehiscence of the Bony Roof of the Canal: An Anatomical Study (2017)

When studying the complex anatomy of the sphenoid sinus, it is essential to consider Vidian canal types. Before endoscopic sinus surgery the Vidian canal and other anatomical structures should be carefully evaluated in all patients during preoperative paranasal sinus CT imaging to avoid complications.
A model of micellization for block copolymers in solutions (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA model of micellization for block copolymers in solutionsZhisheng Gao and Adi EisenbergCite this: Macromolecules 1993, 26, 26, 7353–7360Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ma00078a035https://doi.org/10.1021/ma00078a035research-articleACS PublicationsRequest reuse permissionsArticle Views1431Altmetric-Citations216LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel Selective PDE4 Inhibitors. 1. Synthesis, Structure−Activity Relationships, and Molecular Modeling of 4-(3,4-Dimethoxyphenyl)-2<i>H</i>-phthalazin-1-ones and Analogues (2001)

A number of 6-(3,4-dimethoxyphenyl)-4,5-dihydro-2H-pyridazin-3-ones and a novel series of 4-(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones were prepared and tested on the cGMP-inhibited phosphodiesterase (PDE3) and cAMP-specific phosphodiesterase (PDE4) enzymes. All tested compounds were found to specifically inhibit PDE4 except for pyridazinone 3b, which showed moderate PDE4 (pIC(50) = 6.5) as well as PDE3 (pIC(50) = 6.6) inhibitory activity. In both the pyridazinone and phthlazinone series it was found that N-substitution is beneficial for PDE4 inhibition, whereas in the pyridazinone series it also accounts for PDE4 selectivity. In the phthalazinone series, the cis-4a,5,6,7,8,8a-hexahydrophthalazinones and their corresponding 4a,5,8,8a-tetrahydro analogues showed potent PDE4 inhibitory potency (10/11c,d: pIC(50) = 7.6-8.4). A molecular modeling study revealed that the cis-fused cyclohexa(e)ne rings occupy a region in space different from that occupied by the other fused (un)saturated hydrocarbon rings applied; we therefore assume that the steric interactions of these rings with the binding site play an important role in enzyme inhibition.
Re-measurement of ACS/SBC dark images (2009)

New measurements were made of the SBC dark rate in December 2008. The previous measurement was performed in December 2006. As a function of temperature, the dark rate was found not to have changed over the two year period. A few images were found to have abnormally high count rates which did not fit within the normal temporal pattern. The effect was traced to a flight passage within the outer edges of the South Atlantic Anomaly. As a result of this we have expanded the region within which the SBC must be turned off. The effect of detector temperature on the dark rate is discussed.
<i>Review:</i> Update on Selection of Optimal Radiopharmaceuticals for Clinical Trials (2008)

Multiple formulations of radiopharmaceuticals (RPs) are possible because of engineering at the nanometer scale. Yet, numbers of patients are limited, and the cost of each clinical trial is high. Thus, there is the need of preclinical evaluation of one agent versus another for the selection of an optimal choice. In the application of RPs to cancer, this selection involves both visualization and treatment aspects. In this paper, we propose the use of imaging and therapeutic figures of merit (IFOM and TFOM, respectively) to select the optimal structure and radiolabel for subsequent clinical trials given animal biodistribution results. Limiting cases and Monte Carlo simulation were used to demonstrate that these modern figures of merit are superior to traditional ratio functions that have been employed in these two contexts. Finally, there is the question of how animal and human results resemble each other kinetically. We considered allometry and compared mouse and human results for several of the cognate cT84.66 antibodies (anti-CEA; carcinoembryonic antigen). While kinetics of intact and 120-kDa engineered proteins are similar across the two species, the 80-kDa cognate shows a manifest difference in the RP first moment in the blood. In particular, human blood clearance is slower than that seen in the nude mouse. We suggest that such allometric comparisons become standard in the reporting of clinical trials.
Perylene: A promising organic field-effect transistor material (2000)

Field-effect transistors based on single crystalline perylene have been prepared and analyzed in the temperature range from 50 to 300 K. Room temperature electron mobilities as high as 5.5 cm2/V s have been achieved. In addition, ambipolar device operation, i.e., n- and p-channel activity, is observed. The temperature dependence of the electron and hole mobilities is discussed in the limits of hopping and band-like transport mechanisms. At the request of the authors and editor, this article is being retracted 24 February 2003.
Base Isolation and Damage-Resistant Technologies for Improved Seismic Performance of Buildings (2011)

Modern methods of seismic design (since the 1970s) allow structural engineers to design new buildings with the aim of predictable and ductile behaviour in severe earthquakes, in order to prevent collapse and loss of life. However some controlled damage is expected, which may result in the building being damaged beyond economic repair after severe shaking. Seismic protection of structures has seen significant advances in recent decades, due to the development of new technologies and advanced materials. It has only been recently recognised world-wide that it is possible to design economical structures which can resist severe earthquakes with limited or negligible structural damage. There are two alternative ways of designing buildings to avoid permanent damage in severe earthquakes; base isolation and damage-resistant design. Base isolation requires the building to be separated from the ground by isolation devices which can dissipate energy. This is proven technology which may add a little to the initial cost of the building, but will prove to be less expensive in the long term. Damage-resistant design is developing rapidly, in several different forms. These include rocking walls or rocking frames, with or without post-tensioning, and a variety of energy dissipating devices attached to the building in different ways. If not already the case, damage-resistant design will soon become no more expensive than conventional design for new buildings.
Characterization of the metabolic effects of irisin on skeletal muscle <i>in vitro</i> (2014)

Our observations are the first to document increased metabolism in myocytes through irisin-mediated induction of mitochondrial biogenesis and uncoupling with corresponding gene expression. These observations support the need for further investigation into the therapeutic and pharmacological effects of irisin, as well as development of irisin-based therapy.