gebhart/patrepeval huggingface dataset:
[Prostate carcinoma cell lines and apoptosis: a review]. (2004)

Prostate cancer is a major pathology in industrialized countries. Tumor growth usually results from increased cell proliferation, conjugated with an inhibition of programmed cell death (apoptosis). In this paper, after a short description of the apoptotic mechanisms and their methods of investigation, we review the present knowledge of the implication of different molecular actors in the regulation of apoptosis in prostate cancer cells. This review notably summarizes the present knowledge of the (de)regulation of the effects of androgens, p53, Bcl-2, Bcl-xL, Bax, Akt, PTEN, Par-4, clusterine, caspases and NF-kappaB in prostate adenocarcinoma cell lines and provides an appraisal of their therapeutic potential. A better knowledge of the apoptotic pathways in these cells could indeed allow the development of new selective and effective anti-cancer strategies.
Sparsity promoting morphological decomposition for coherent noise suppression: Application to streamer vibration related noise (2016)

We address the signal and noise separation problem where the noise is coherent. We use a dictionary learning method to learn a dictionary of unit vectors called atoms; each one representing an elementary waveform redundant in the noisy data. In such a learned dictionary, some atoms represent signal waveforms while others represent noise waveforms. Using a multivariate Gaussian classifier trained on a noise recording, the atoms representing noise waveforms are discriminated and separated from the atoms representing seismic waveforms and two sub-dictionaries are created; one describing the morphology of the signal, the other describing the morphology of the noise. Using these sub-dictionaries, a morphological component analysis problem is set to separate the seismic signal and the coherent noise. In contrast to fixing transforms for representing the noise and the signal, our method is entirely adapting to the morphology of the signal and the noise. We present an application for removing streamer vibration related noise and show successful denoising results on synthetic and field data examples. Presentation Date: Monday, October 17, 2016 Start Time: 4:10:00 PM Location: 140 Presentation Type: ORAL
A Novel Halogen-Free, Phosphorous-free and Heat Resistant Material for Copper clad laminate (2008)

Brominated and phosphorous-containing type epoxy resins are important binders for current flame retardant CCL (copper clad laminate). Nevertheless, they will cause environment problems. Brominated type resins will generate dioxins from inappropriate incineration condition and phosphorous type resins may cause the pollution of aquatic environment. On July 1, 2006, two important directives on environment protection were releasecedy European Union, i.e., RoHS and WEEE. The Sn-Pb solder shouldbe replaced by lead free type solder and the JR Reflow will increase from 200degC to 255degC. Given the above, we developed a new halogen-free and phosphorous-free composition, which is comprising nitrogen-containing resin, inorganic filler and modifier . The nitrogen and inorganic filler impart CCL with flame-retardant properties and render CCL more environment-friendly. The new product is also good in heat properties and can meet the specification of IPC41O1B.
Triple Immunofluorescence Staining with Antibodies Raised in the Same Species to Study the Complex Innervation Pattern of Intrapulmonary Chemoreceptors (2002)

A general problem in immunocytochemistry is the development of a reliable multiple immunolabeling method when primary antibodies must be used that originate in the same species. We have developed a protocol for the immunodetection of three antigens in a single tissue preparation, using unconjugated primary antibodies raised in the same species. Immunocytochemical detection of neuronal nitric oxide synthase, calcitonin gene-related peptide, and calbindin D28k in the lung of rats demonstrated that part of the pulmonary neuroepithelial bodies are selectively contacted by at least three different nerve fiber populations. The first antigen was detected using tyramide signal amplification, a very sensitive method allowing a dilution of the first primary antibody far beyond the detection limit of fluorescently labeled secondary antibodies. The second antigen was visualized by a fluorophore-conjugated secondary monovalent Fab antibody that at the same time blocks the access of the third secondary antibody to the second primary antibody. Moreover, the monovalence of the Fab fragment prevents the third primary antibody from binding with the second-step secondary antibody. The triple staining technique described here is generally applicable, uses commercially available products only, and allows the detection of three antigens in the same preparation with primary antibodies that are raised in the same species.
Two ascomycete classes based on fruiting-body characters and ribosomal DNA sequence. (1992)

Traditional fruiting body-based classification of ascomycetes has been under attack for 2 decades. Fruitingbody types can converge, and few researchers now assume that either the closed fruiting bodies (cleistothecia) characterizing the class Plectomycetes or the flask-shaped fruiting bodies (perithecia) characterizing the class Pyrenomycetes are stable, unifying characters. Unless we identify characters uniting major ascomycete groups, orders of ascomycetes remain narrowly defined, and supraordinal classification is impossible. We sequenced both strands of 18s rDNA from nine ascomycete fungi, adding three sequences from GenBank into our analysis. The phylogeny, inferred from 162 informative sites in 1,700 bp of DNA sequence data and using yeast as an outgroup, divided the fungi into two groups correlating well both with fruiting-body type and with the traditional classes Plectomycetes and Pyrenomycetes.
Concurrent simulation of nearly identical digital networks (1974)

Test patterns for testing digital circuits are usually checked on a test verification program to determine if all or most of the possible faults will be detected. Historically, such a test verification program would be accomplished with many simulations: one for each possible fault.
Effect of Endotoxin on Ventilation and Breath Variability (2001)

To evaluate the effects of endotoxemia on respiratory controller function, 12 subjects were randomized to receive endotoxin or saline; six also received ibuprofen, a cyclooxygenase inhibitor, and six received placebo. Administration of endotoxin produced fever, increased respiratory frequency, decreased inspiratory time, and widened alveolar-arterial oxygen tension gradient (all p < or = 0.001); these responses were blocked by ibuprofen. Independent of ibuprofen, endotoxin produced dyspnea, and it increased fractional inspiratory time, minute ventilation, and mean inspiratory flow (all p < or = 0.025). Endotoxin altered the autocorrelative behavior of respiratory frequency by increasing its autocorrelation coefficient at a lag of one breath, the number of breath lags with significant serial correlations, and its correlated fraction (all p < 0.05); these responses were blocked by ibuprofen. Changes in correlated behavior of respiratory frequency were related to changes in arterial carbon dioxide tension (r = 0.86; p < 0.03). Endotoxin decreased the oscillatory fraction of inspiratory time in both the placebo (p < 0.05) and ibuprofen groups (p = 0.06). In conclusion, endotoxin produced increases in respiratory motor output and dyspnea independent of fever and symptoms, and it curtailed the freedom to vary respiratory timing-a response that appears to be mediated by the cyclooxygenase pathway.
Site-specific anti-phosphopeptide antibodies: use in assessing insulin receptor serine/threonine phosphorylation state and identification of serine-1327 as a novel site of phorbol ester-induced phosphorylation (1994)

Rabbit antisera were raised against synthetic phosphopeptides corresponding to defined or putative sites of insulin receptor serine/threonine phosphorylation (Ser-1305, Ser-1327, Thr-1348). All of these antibodies bound specifically to the immunogenic phosphopeptide but not to the non-phosphorylated form of the peptide or to other phosphopeptides, in a microtitre plate competition enzyme-linked immunosorbent assay. Anti-PS1327 antibody reacted well with native insulin receptor prepared from phorbol ester-treated transfected CHO.T cells, but showed little reaction with receptor from untreated cells. Anti-PT1348 antibody in crude form reacted substantially with receptor from both phorbol 12-myristate 13-acetate-treated and untreated cells, but displayed specificity for phosphoreceptor after adsorption to remove antibodies reactive with dephosphopeptide. The ability to discriminate between receptor from cells treated with or without phorbol ester was retained when these antibodies were used to probe denatured receptor on Western blots. Thus anti-PS1327 and anti-PT1348 react with insulin receptor in a site-specific and phosphorylation-state-dependent manner. Anti-PT1348, but not anti-PS1327, also showed increased reactivity with receptor prepared from insulin-treated cells. The third antibody, anti-PS1305, did not react with intact insulin receptor under any conditions. It is concluded that serine 1327 is a major, previously unrecognized, site of phorbol ester-induced receptor phosphorylation, and that anti-phosphopeptide antibodies will be valuable reagents with which to examine the serine/threonine phosphorylation state of receptor extracted from tissues.
Solar Syngas Production via H<sub>2</sub>O/CO<sub>2</sub>-Splitting Thermochemical Cycles with Zn/ZnO and FeO/Fe<sub>3</sub>O<sub>4</sub> Redox Reactions (2009)

The solar production of syngas from H2O and CO2 is examined via two-step thermochemical cycles based on Zn/ZnO and FeO/Fe3O4 redox reactions. The first, endothermic step is the thermal dissociation of the metal oxide using concentrated solar radiation as the energy source of high-temperature process heat. The second, nonsolar, exothermic step is the reaction of the metal or reduced metal oxide with a mixture of H2O and CO2 yielding syngas (H2 and CO), together with the initial form of the metal oxide that is recycled to the first step. Chemical equilibrium compositions for the systems of Zn and FeO with CO2 + H2O were computed as a function of temperature and pressure for different stoichiometries. A series of dynamic thermogravimetric experimental runs in the range 673−1423 K was carried out to evaluate the reaction kinetics and syngas quality of the second step. The molar flow rate fractions of the gaseous products exhibited linear dependencies on the molar flow rate fractions of the gaseous reactants for both the FeO/Fe3O4 and Zn/ZnO systems.
Electrospray mass spectrometry for the analysis of opioid peptides and for the quantification of endogenous methionine enkephalin and β-endorphin (1991)

Electrospray ionization mass spectrometry was used to characterize several different neuropeptides, whose molecular weights ranged from 555 to 3463 Da, and to quantify endogenous methionine enkephalin (ME) and β -endorphin (β E) extracted from a human pituitary gland. Methionine enkephalin and leucine enkephalin both yield only an [M + H] + ion with electrospray mass spectrometry; the other peptides produce a series of multiply charged even-electron molecular ions of the general nature [M + nH](n)+ in proportion to the number of basic amino acid units present, with no evidence of fragmentation. The electrospray mass spectra are characterized by low background noise. The quantiftcation of ME is based on a comliarison of the ion current due to the [M + H] + ion of native and of a deuterated ME ([(2)H5 s-(4)Phe]-ME) internal standard. The calibration curve is linear in the range of ca. 1-35 pmol synthetic ME. The amounts of ME determined in three separate human pituitary extracts were 9.1, 8.2, and 4.7 pmol/mg protein. The corresponding amount of ME in a canine pituitary was 39.8 pmol/mg protein. To quantify β E, the ion current due to the [M + 5H](5) + ion was monitored and compared to an external calibration curve obtained by analyzing solutions of synthetic β E in the range 5 μmol-50 pmol. The analysis of a human pituitary yielded 660 fmol β E/mg protein.
Fucosyllactose and L-fucose utilization of infant Bifidobacterium longum and Bifidobacterium kashiwanohense (2016)

Here we observed that the ability to utilize fucosyllactose is a trait of various bifidobacteria species. For the first time, strains of B. longum subsp. infantis and an isolate of B. longum subsp. suis were shown to use L-fucose to form 1,2-PD. As 1,2-PD is a precursor for intestinal propionate formation, bifidobacterial L-fucose utilization may impact intestinal short chain fatty acid balance. A L-fucose utilization pathway for bifidobacteria is suggested.
Plasmavolumenbestimmung mit dem Farbstoff ICG bei Änderung des intravasalen Volumens (1996)

<i>Ziel:</i> Die Messung des aktuellen intravasalen Volumens mit Hilfe der Indikator-Verdünnungsmethode ist sowohl von klini-schem als auch von wissenschaftlichem Interesse. Bei der Ver-wendung des rasch eliminierten Farbstoffes Indocyanin-Grün (ICG) sind wiederholte Messungen und damit Verlaufskontrollen möglich. In der vorliegenden Studie sollten folgende Fragen geprüft werden: 1. Stimmen die von uns mit der ICG-Methode bei gesunden Probanden bestimmten Werte mit den in der Literatur angegebenen Kontrollwerten überein, und ist somit die Grundlage für die Durchführung weiterer klinischer Studien gegeben, und 2. Stimmen die Differenzen der vor und nach Eigenblutentnahme bzw. Retransfusion bestimmten Werte für das Plasmavolumen mit den tatsächlich entnommenen bzw. retransfundierten Volumina überein? <i>Design:</i> Prospektive Studie (an je 20 gesunden weiblichen bzw. männlichen Probanden). <i>Rahmen:</i> Forschungslabor einer anästhesiologischen Universitätsklinik. <i>Teilnehmer:</i> Je 20 gesunde weibliche bzw. männliche Probanden. <i>Interventionen:</i> Plasmavolumenbestimmung mit ICG vor und nach Entnahme von 10% des ge-schätzten Blutvolumens und nach Retransfusion. <i>Ergebnisse:</i> In der Gruppe der Frauen betrug das Plasmavolumen pro Körperoberfläche (PV/KO) 1639 ± 198 und bei den Männern 1687 ± 224 ml/m2 (Mittelwert ± SD). Durch die Eigenblutspende wurde den Frauen 188 ± 23 und den Männern 149 ± 26 ml/m2 PV entzogen. Die PV-Messung mit ICG ergab für diesen Ent-zug einen Wert von 198 ± 174 bzw. 171 ± 158 ml/m2 und für die Retransfusion 190 ± 169 bzw. 142 ± 154 ml/m2. <i>Schlu</i>β<i>folgerungen:</i> Die Kontrollwerte liegen in dem in der Literatur be-schriebenen Normbereich. Die gemessenen Differenzen der Plasmavolumina vor und nach Eigenblutspende bzw. nach Retransfusion stimmen mit den tatsächlich entnommenen Plasmavolumina im Mittel gut überein. Bei der klinischen Beurteilung im Einzelfall ist die methodisch bedingte hohe Standardabweichung zu berücksichtigen.
Process Improvements in the Synthesis of Corticosteroid 9,11β-Epoxides (2001)

Corticosteroid 9,11β-epoxides are key intermediates in the preparation of pharmaceutically important compounds such as betamethasone, mometasone, beclomethasone, and dexamethasone. A new process for the 9,11β-epoxide was developed using a PCl5-mediated regioselective dehydration of 11α-hydroxysteroid to form the corresponding Δ9,11 double bond. The olefin is then converted into 9α,11β- bromoformate by treatment with 1,3-dibromo-5, 5-dimethyl hydantoin (DBH) in DMF and subsequently cyclized to produce the desired 9,11β-epoxide upon treatment with NaOH. Major process-related impurities such as 21-OH-Δ9,11-triene, 21-OH-Δ11,12-triene, 21-Cl-Δ9,11-triene, and β-epoxide-21-cathylate as well as 11β-Cl are all eliminated or minimized. This new process has been implemented in our manufacturing facility in full-scale production and proved to raise the overall yield and the quality of the product dramatically compared to the existing process.
"Old Familiar Faces" (1939)

"Old Familiar Faces" Get access M. U. H. R. M. U. H. R. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 176, Issue 1, 7 January 1939, Page 12, https://doi.org/10.1093/nq/176.1.12a Published: 07 January 1939
<scp>H</scp> mong (2015)

The Hmong are an Asian ethnic minority dispersed around the globe by the twenty‐first century. Of the estimated five to six million people of Hmong ethnicity in the world, the largest number is found in southern China, followed by Vietnam, Laos, and Thailand. After the Second Indochina War, thousands of Hmong from Laos became political refugees and subsequently settled in the United States. Smaller populations migrated to Argentina, Australia, Canada, and France (French Guiana). While no Hmong nation‐state exists, nation‐building efforts have been an integral part of Hmong history across place and time.
Multimedia News Summarization in Search (2016)

It is a necessary but challenging task to relieve users from the proliferative news information and allow them to quickly and comprehensively master the information of the whats and hows that are happening in the world every day. In this article, we develop a novel approach of multimedia news summarization for searching results on the Internet, which uncovers the underlying topics among query-related news information and threads the news events within each topic to generate a query-related brief overview. First, the hierarchical latent Dirichlet allocation (hLDA) model is introduced to discover the hierarchical topic structure from query-related news documents, and a new approach based on the weighted aggregation and max pooling is proposed to identify one representative news article for each topic. One representative image is also selected to visualize each topic as a complement to the text information. Given the representative documents selected for each topic, a time-bias maximum spanning tree (MST) algorithm is proposed to thread them into a coherent and compact summary of their parent topic. Finally, we design a friendly interface to present users with the hierarchical summarization of their required news information. Extensive experiments conducted on a large-scale news dataset collected from multiple news Web sites demonstrate the encouraging performance of the proposed solution for news summarization in news retrieval.
The Sixth Sapling (2007)

I love the form argument takes in Talmud. Unlike in the classroom where the right response is inevitably sought, the Rabbis seem rather to eschew answer to pursue method. In the midst of the discussion begun in the previous chapter concerning the length of the workday and the content of the worker's meal, the issue of local custom is suddenly dropped and no further talk about this topic will be undertaken for a considerable amount of time. Oh, the Rabbis will certainly return to the issue, but not until after a remarkable, lengthy and, for my purposes, fascinating and illuminating digression. Specifically, in the midst of this conversation regarding the length of the workday, this remarkable shift occurs: Rabbi Zera expounded (and some say Rav Yosef taught): "What is it that is written: 'You make darkness, and it is night, wherein all the beasts of the forest creep forth?'" KeywordsGrade LevelLocal CustomComic BookIndividual Education PlanStealing TimeThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Design and Development of Information System Template Prototype for Maritime Transportation (2013)

This paper details the step-by-step production of a real world scenario and modular template for a marine information system from the theories involved to its design, development, implementation and tests. Data and information from the global positioning system (GPS), digital compass (DC), automatic identification system (AIS) and electronic navigational charts (ENC) were utilized to display map, map data, directional, location and ship related information. The data and other information display orientation remains in legible horizontal manner even if the base map is moving or transforming while several utilities such as serial device connection configuration and data retrieval was written for technical and testing purposes. This work was done to come-up with a template for developing a marine vehicle system that will serve as a reference or basis for future system developmental works. The modular and compartmentalized design of the system makes it very easy to customize for further specific development such as a Marine Vehicle Monitoring System or Marine Navigation System.
Study of in vitro transcriptional binding effects and noise using constitutive promoters combined with UP element sequences in Escherichia coli (2017)

These results demonstrate the utility of UP elements and provide mechanistic insight into the functional relationship between binding affinity and transcription. Given the centrality of gene expression via transcription to biology, additional insight into transcriptional mechanisms can foster both fundamental and applied research. In particular, knowledge of the DNA sequence-specific effects on expression strength can aid in promoter engineering for different organisms and for metabolic engineering to balance pathway fluxes.
Lead‐Free Organic–Inorganic Hybrid Perovskites for Photovoltaic Applications: Recent Advances and Perspectives (2017)

Organic-inorganic hybrid halide perovskites (e.g., MAPbI<sub>3</sub> ) have recently emerged as novel active materials for photovoltaic applications with power conversion efficiency over 22%. Conventional perovskite solar cells (PSCs); however, suffer the issue that lead is toxic to the environment and organisms for a long time and is hard to excrete from the body. Therefore, it is imperative to find environmentally-friendly metal ions to replace lead for the further development of PSCs. Previous work has demonstrated that Sn, Ge, Cu, Bi, and Sb ions could be used as alternative ions in perovskite configurations to form a new environmentally-friendly lead-free perovskite structure. Here, we review recent progress on lead-free PSCs in terms of the theoretical insight and experimental explorations of the crystal structure of lead-free perovskite, thin film deposition, and device performance. We also discuss the importance of obtaining further understanding of the fundamental properties of lead-free hybrid perovskites, especially those related to photophysics.
Convolution Filtering of Continuous Signed Distance Fields for Polygonal Meshes (2015)

Abstract Signed distance fields obtained from polygonal meshes are commonly used in various applications. However, they can have C 1 discontinuities causing creases to appear when applying operations such as blending or metamorphosis. The focus of this work is to efficiently evaluate the signed distance function and to apply a smoothing filter to it while preserving the shape of the initial mesh. The resulting function is smooth almost everywhere, while preserving the exact shape of the polygonal mesh. Due to its low complexity, the proposed filtering technique remains fast compared to its main alternatives providing C 1 ‐continuous distance field approximation. Several applications are presented such as blending, metamorphosis and heterogeneous modelling with polygonal meshes.