gebhart/patrepeval huggingface dataset:
Altered expression of renal AQPs and Na<sup>+</sup>transporters in rats with Lithium-induced NDI (2000)

Lithium (Li) treatment is often associated with nephrogenic diabetes insipidus (NDI). The changes in whole kidney expression of aquaporin-1 (AQP1), -2, and -3 as well as Na-K-ATPase, type 3 Na/H exchanger (NHE3), type 2 Na-Pi cotransporter (NaPi-2), type 1 bumetanide-sensitive Na-K-2Cl cotransporter (BSC-1), and thiazide-sensitive Na-Cl cotransporter (TSC) were examined in rats treated with Li orally for 4 wk: protocol 1, high doses of Li (high Na(+) intake), and protocol 2, low doses of Li (identical food and normal Na(+) intake in Li-treated and control rats). Both protocols resulted in severe polyuria. Semiquantitative immunoblotting revealed that whole kidney abundance of AQP2 was dramatically reduced to 6% (protocol 1) and 27% (protocol 2) of control levels. In contrast, the abundance of AQP1 was not decreased. Immunoelectron microscopy confirmed the dramatic downregulation of AQP2 and AQP3, whereas AQP4 labeling was not reduced. Li-treated rats had a marked increase in urinary Na(+) excretion in both protocols. However, the expression of several major Na(+) transporters in the proximal tubule, loop of Henle, and distal convoluted tubule was unchanged in protocol 2, whereas in protocol 1 significantly increased NHE3 and BSC-1 expression or reduced NaPi-2 expression was associated with chronic Li treatment. In conclusion, severe downregulation of AQP2 and AQP3 appears to be important for the development of Li-induced polyuria. In contrast, the increased or unchanged expression of NHE3, BSC-1, Na-K-ATPase, and TSC indicates that these Na(+) transporters do not participate in the development of Li-induced polyuria.
A General Recommendation Model for Heterogeneous Networks (2016)

Heterogeneous networks refer to the networks comprising multiple types of entities as well as their interaction relationships. They arise in a great variety of domains, for example, event-based social networks Meetup and Plancast, and DBLP. Recommendation is a useful task in these heterogeneous network systems. Although many recommendation algorithms are proposed for heterogeneous data, none of them is able to explicitly model the influence strength between different types of entities, which is useful not only for achieving higher recommendation accuracy but also better understanding the role of each entity type in recommendation problems. Moreover, many of those algorithms are designed for a particular task, and hence it is challenging to apply them in other problems. In this paper, we propose a graph-based model, called HeteRS, which can solve general recommendation problems on heterogeneous networks. Our method models the rich information with a heterogeneous graph and considers the recommendation problem as a query-dependent node proximity problem. To address the challenging issue of weighting the influences between different types of entities, we propose a learning scheme to set the influence weights between different types of entities in recommendation. Experimental results on real-world datasets demonstrate that our proposed method significantly outperforms the baseline methods in our experiments for all the recommendation tasks, and the learned influence weights help understanding user behaviors.
Ferritin as an indicator of disease activity in Hodgkin lymphoma in pediatric patients. (2022)

Serum ferritin at baseline statistically correlated with disease activity however the final ferritin values reduced to significant values in patient that underwent remission, and hence grouping of patients based on serum ferritin values can serve as better outcome predictors. Although transfusion requirement was very rare in the patients the levels of serum ferritin correlated with disease activity. Serum ferritin level may act as a predictor of disease activity and remission.
Very low threshold buried ridge structure lasers emitting at 1.3 μm grown by low pressure metalorganic chemical vapor deposition (1985)

GaInAsP-InP buried ridge structure lasers emitting at 1.3 μm have been fabricated on material grown completely by low pressure metalorganic chemical vapor deposition. These lasers have low threshold (11 mA), exhibit linear (kink-free) light-current characteristics up to high powers (10 mW/facets), and can be operated at high temperatures (70 °C). Excellent uniformity over 10 cm2 has been obtained, and an external quantum efficiency of 60% for two faces has been measured.
Advances In Computational Fluid Dynamics: Turbulent Separated Flows And Transonic Potential Flows (1997)

Computational solutions are presented for flows ranging from incompressible viscous flows to inviscid transonic flows. The viscous flow problems are solved using the incompressible Navier-Stokes equations while the inviscid solutions are attained using the full potential equation. Results for the viscous flow problems focus on turbulence modeling when separation is present. The main focus for the inviscid results is the development of an unstructured solution algorithm. The subject dealing with turbulence modeling for separated flows is discussed first. Two different test cases are presented. The first flow is a low-speed convergingdiverging duct with a rapid expansion, creating a large separated flow region. The second case is the flow around a stationary hydrofoil subject to small, oscillating hydrofoils. Both cases are computed first in a steady state environment, and then with unsteady flow conditions imposed. A special characteristic of the two problems being studied is the presence of strong adverse pressure gradients leading to flow detachment and separation. For the flows with separation, numerical solutions are obtained by solving the incompressible
Scaling Behavior of the Spin Pumping Effect in Ferromagnet-Platinum Bilayers (2011)

We systematically measured the dc voltage V(ISH) induced by spin pumping together with the inverse spin Hall effect in ferromagnet-platinum bilayer films. In all our samples, comprising ferromagnetic 3d transition metals, Heusler compounds, ferrite spinel oxides, and magnetic semiconductors, V(ISH) invariably has the same polarity, and scales with the magnetization precession cone angle. These findings, together with the spin mixing conductance derived from the experimental data, quantitatively corroborate the present theoretical understanding of spin pumping in combination with the inverse spin Hall effect.
An alternative closed-form solution to the GPS pseudo-range equations (1996)

In the four satellite Global Positioning System (GPS) problem, the system of pseudo-range equations is shown to be equivalent to a system of two linear equations together with a range difference and pseudo-range equation. The formulation represents the user's position as the intersection of two planes and a hyperbola branch of revolution. The formulation is three-dimensional and includes almost all degenerate and special case geometries. It provides geometric insight into the characteristics of the solutions and resolves existence and uniqueness questions regarding solution of the pseudo-range equations.
Assessment of different pillar geometries for 1-3 composite transducers using finite element analysis (2002)

Composite piezoelectric transducers, comprising piezoceramic pillars aligned within a polymer matrix, exhibit a high electromechanical coupling coefficient and a low acoustic impedance. Finite element analysis is used to investigate the dependence of device performance, in terms of electromechanical efficiency and vibrational uniformity, on pillar geometry. Results obtained by using alternative pillar shapes, including circular, square, and triangular geometries, are discussed, and an overall design strategy is formulated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
NOTES ON THE CLAYTON HERBARIUM (1918)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Rapid formation of block copolymer thin film based on infrared laser irradiation (2007)

A fast and reliable nanofabrication process to prepare thin films of diblock copolymer is essential for enabling their applications in microelectronics. We present a novel technique of shortening self-assembled time significantly by direct exposing diblock copolymer films to a pulsed CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> laser light.
Structural analysis of the lipopolysaccharide from <i>Chlamydophila psittaci</i> strain 6BC (2000)

The lipopolysaccaride of Chlamydophila psittaci 6BC was isolated from tissue culture-grown elementary bodies using a modified phenol/water procedure followed by extraction with phenol/chloroform/light petroleum. Compositional analyses indicated the presence of 3-deoxy-Dmanno-oct-2-ulosonic acid, GlcN, organic bound phosphate and fatty acids in a molar ratio of approximately 3. 3 : 2 : 1.8 : 4.6. Deacylated lipopolysaccharide was obtained after successive microscale treatment with hydrazine and potassium hydroxide, and was then separated by high performance anion-exchange chromatography into two major fractions, the structures of which were determined by 600 MHz NMR spectroscopy as alpha-Kdo-(2-->8)-alpha-Kdo-(2-->4)-alpha-Kdo-(2-->6)-beta-D-GlcpN -(1 -->6)-alpha-D-GlcpN 1,4'-bisphosphate and alpha-Kdo-(2-->4)-[alpha-Kdo-(2-->8)]-alpha-Kdo-(2-->4)-alpha-Kdo-(2- ->6)-beta-D-GlcpN-(1-->6)-alpha-D-GlcpN 1,4'-bisphosphate. The distribution of fatty acids in lipid A was determined by compositional analyses and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry experiments on lipid A and de-O-acylated lipid A. It was shown that the carbohydrate backbone of lipid A is replaced by a complex mixture of fatty acids, including long-chain and branched (R)-configured 3-hydroxy fatty acids, the latter being exclusively present in an amide linkage.
PHOTOPROTECTION REVISITED:<i>Genetic and Molecular Approaches</i> (1999)

The involvement of excited and highly reactive intermediates in oxygenic photosynthesis poses unique problems for algae and plants in terms of potential oxidative damage to the photosynthetic apparatus. Photoprotective processes prevent or minimize generation of oxidizing molecules, scavenge reactive oxygen species efficiently, and repair damage that inevitably occurs. This review summarizes several photoprotective mechanisms operating within chloroplasts of plants and green algae. The recent use of genetic and molecular biological approaches is providing new insights into photoprotection, especially with respect to thermal dissipation of excess absorbed light energy, alternative electron transport pathways, chloroplast antioxidant systems, and repair of photosystem II.
Negative effect of a protein kinase C inhibitor (H-7) on human polymorphonuclear neutrophil locomotion. (1988)

The effects of 1-(5-isoquinoline sulphonyl)-2-methyl piperazine (H-7), a recently described inhibitor of Ca2+/phospholipid-dependent protein kinase (protein kinase C), were studied during under-agarose migration of human polymorphonuclear neutrophils (PMN) stimulated by various chemoattractants, in order to determine whether protein kinase C is involved in PMN locomotion. The effect of H-7 on the oxidative burst induced by phorbol 12-myristate 13-acetate or N-formyl-methionyl-leucyl-phenylalanine (FMLP) was also measured. Pre-incubation of PMN with H-7 concentrations ranging from 50 to 400 microM inhibited: (i) spontaneous PMN migration under agarose; (ii) the directed migration induced by activated serum, leukotriene B4 or FMLP; and (iii) the speed of the migration induced by FMLP. The inhibition by H-7 of FMLP-induced directed migration was less when FMLP was used at high concentrations which, in the absence of H-7, inhibit locomotion. H-7 depressed the oxidative burst induced by phorbol myristate acetate (PMA) but not that induced by FMLP. All the effects of H-7 on the oxidative burst and migration were reversed by washing PMN after H-7 treatment. These findings indicate that protein kinase C, inhibitable by H-7, is involved in a mechanism controlling the speed of PMN locomotion.
Intramyocardial Transplantation of Autologous Myoblasts (2000)

Background —Autologous skeletal myoblast (SM) transplantation improves function of infarcted myocardium, but pretransplantation cultures remain a complex process. This study assessed whether it could be optimized by muscle preconditioning with the local anesthetic bupivacaine or even bypassed with the use of the so-called mince technique. Methods and Results —Muscle preconditioning consisted of intramuscular injections of the tibialis anterior of rats, 2 days before harvest. After 7 days of culture, the number of available myoblasts was significantly increased compared with nonconditioned controls (1 683 147 versus 85 300, P =0.0013). The mince technique was then assessed. A myocardial infarction was created in 66 rats by coronary artery ligation. One week later, rats were reoperated on and intramyocardially injected with culture medium alone (controls, n=23), autologous cultured SM (3.5×10 6 , n=21), or autologous muscle minced into a fine slurry, which was immediately transplanted (n=22). All muscles had been preconditioned. Left ventricular function was assessed by 2D echocardiography. Whereas end-diastolic volumes expanded over time in all groups, left ventricular ejection fraction (%, mean±SEM) was increased only in the cultured SM–transplanted group at 1 ( P =0.0006) and 2 months ( P =0.0008) versus baseline (37.52±1.92 and 40.92±2.17 versus 30.34±1.74), with a significant additional benefit between 1 and 2 months ( P =0.0069). Conclusions —Cell culture remains mandatory for SM transplantation to be successful but, in a clinical perspective, this process can be made more expeditious by preharvest muscle conditioning with bupivacaine, which greatly enhances the baseline cell yield.
D. H. Hill Library (1959)

The D. H. Hill Library at North Carolina State College has acquired a 6,200-volume collection of entomological books. Many of the volumes are rare, very rare, and scarce. The collection weighed 5½ tons together with the packing. It was originally owned by Dr. Fredrich F. Tippmann, a Viennese engineer and amateur entomologist for most of his life. We feel this is a magnificent acquisition for North Carolina State College and know that we will be able to make good use of it, and we want our friends from other institutions to know about it so that they also Call make use of the collection either by visiting it here or through interlibrary loans. The vast majority of the items were not previously in the North Carolina State College Library, and a considerable number of the items are almost unprocurable today.
An audio wiki supporting mobile collaboration (2008)

Wikis have proved to be very effective collaboration and knowledge management tools in large variety of fields thanks to their simplicity and flexible nature. Another important development for the internet is the emergence of powerful mobile devices supported by fast and reliable wireless networks. The combination of these developments begs the question of how to extend wikis on mobile devices and how to leverage mobile devices' rich modalities to supplement current wikis. Realizing that composing and consuming through auditory channel is the most natural and efficient way for mobile device user, this paper explores the use of audio as the medium of wiki. Our work, as the first step towards this direction, creates a framework called Mobile Audio Wiki which facilitates asynchronous audio-mediated collaboration on the move. In this paper, we present the design of Mobile Audio Wiki. As a part of such design, we propose an innovative approach for a light-weight audio content annotation system for enabling group editing, versioning and cross-linking among audio clips. To elucidate the novel collaboration model introduced by Mobile Audio Wiki, its four usage modes are identified and presented in storyboard format. Finally, we describe the initial design for presentation and navigation of Mobile Audio Wiki.
Current Applications of Facial Volumization with Fillers (2016)

Facial volumization is widely applied for minimally invasive facial rejuvenation both as a solitary means and in conjunction with surgical correction. Appropriate facial volumization is dependent on patient characteristics, consistent longitudinal anatomical changes, and qualities of fillers available. In this article, anatomical changes seen with aging are illustrated, appropriate techniques for facial volumization are described in the setting of correct filler selection, and potential complications are addressed.
Human Immunization with Pgh 3-2 Gonococcal Pilus Results in Cross-Reactive Antibody to the Cyanogen Bromide Fragment-2 of Pilin (1991)

In 1983, a gonococcal pilus vaccine failed to show protection in a large, placebo-controlled, double-blind field trial. The epitopic response to this vaccine was investigated in a random subgroup of 20 vaccine recipients. Using Western blot analysis of the immunizing pilus and its cyanogen bromide (CNBr) fragments, IgG antibody to pilin was detected before immunization in all individuals. Preexistent antibody to the CNBr-2 and CNBr-3 fragments of pilin was detected in 65% and 5% of individuals, respectively. Pilus immunization resulted in a vigorous response to the CNBr-2 fragment in 100% of the individuals tested; only 33% developed antibody to the CNBr-3 fragment. Absorptions of postimmunization sera with different gonococcal strains resulted in either complete or partial removal of antibody to the CNBr-2 fragment. In the context of an unsuccessful vaccine trial, these results suggest that antibody to the CNBr-2 fragment of pilin may not be protective.
Enrichment of fermentation media and optimization of expression conditions for the production of EAK<sub>16</sub> peptide as fusions with SUMO (2008)

EAK(16) (AEAEAKAKAEAKAEAK) belongs to a novel class of self-assembling peptides, which is being investigated in research and industry. SUMO belongs to the ubiquitin class of proteins and is a promising fusion partner currently in use. In this study, EAK(16) peptide fusions with hexa-histidine tagged SUMO have been constructed using Escherichia coli based pET expression vector. Intracellular expression of the SUMO-EAK(16) fusion using LB media has been optimized. Low-cost complex media (fungal autolysates, wheat and gluten hydrolysates) produced via a novel wheat-based biorefinery have been used as alternative fermentation media to LB. Shake flask cultures using either enriched LB or complex wheat-derived media containing 2 g/L of glucose resulted in intracellular SUMO-EAK(16) fusion protein production of approximately 250 mg/L fermentation volume which corresponded to 30-35% of the total bacterial protein expressed being the fusion protein. Fusion protein productivities up to five times higher were achieved when using a bioreactor.
Effects of Lights of Different Color Temperature on the Nocturnal Changes in Core Temperature and Melatonin in Humans. (1996)

A variety of types of artificial illumination has recently become available, differing in the quality of illumination and range of color temperature. In our previous studies we found that in subjects with normal color vision the nocturnal fall in core temperature and the increase of urinary melatonin excretion were suppressed by bright blue or green light, but not by bright red or dim lights. The aim of our present study was to examine from the view point of chronobiology whether the lights of different color temperature often used in everyday life may affect core temperature and urinary melatonin secretion differently. Experiments were carried out on five subjects with normal color vision. They were exposed for 5 hr (from 21:00 h to 2:00 h) to two kinds of bright (1000 lx) light of different color temperature (6500 K, 3000 K) with dim (50 lx) light as a control; after exposure they slept in darkness. Our main results were as follows: The light with a high color temperature of 6500 K more strongly suppressed the nocturnal fall of the core temperature and the nocturnal increase of melatonin secretion than the light with a low color temperature of 3000 K. This difference was particularly evident for core temperature during the sleep period following experimental illumination.
RNA processing and ribonucleoprotein assembly studied in vivo by RNA transfection. (1990)

We present a method for studying RNA processing and ribonucleoprotein assembly in vivo, by using RNA synthesized in vitro. SP6-transcribed 32P-labeled U2 small nuclear RNA precursor molecules were introduced into cultured human 293 cells by calcium phosphate-mediated uptake, as in standard DNA transfection experiments. RNase protection mapping demonstrated that the introduced pre-U2 RNA underwent accurate 3' end processing. The introduced U2 RNA was assembled into ribonucleoprotein particles that reacted with an antibody specific for proteins known to be associated with the U2 small nuclear ribonucleoprotein particle. The 3' end-processed, ribonucleoprotein-assembled U2 RNA accumulated in the nuclear fraction. When pre-U2 RNA with a 7-methylguanosine group at the 5' end was introduced into cells, it underwent conversion to a 2,2,7-trimethylguanosine cap structure, a characteristic feature of the U-small nuclear RNAs. Pre-U2 RNA introduced with an adenosine cap (Ap-ppG) also underwent processing, small nuclear ribonucleoprotein assembly, and nuclear accumulation, establishing that a methylated guanosine cap structure is not required for these steps in U2 small nuclear ribonucleoprotein biosynthesis. Beyond its demonstrated usefulness in the study of small nuclear ribonucleoprotein biosynthesis, RNA transfection may be of general applicability to the investigation of eukaryotic RNA processing in vivo and may also offer opportunities for introducing therapeutically targeted RNAs (ribozymes or antisense RNA) into cells.
Java Server Reliability in the Presence of Failures (2017)

A design for the separation of a server interface and work processing. Numerous sources, Tanenbaum (Tanenbaum Modern Operating Systems, 493), Goscinski (Goscinski Distributed operating systems, 203), and Birman (Birman Reliable distributed systems, 265), all discuss the concept of Two-Phase Commit, where a coordinator directs one or more processes to perform a transaction. If the transaction or any of the processes fail, the coordinator can decide how to proceed by either retrying or aborting the request. The popular web browser Chrome utilizes a separate process for each tab displayed. Should the rendering and display of a web page cause a crash, the Chrome application itself does not. The implementation leads to a search of available Java IPC (Inter-process communication) methods, presenting a review of Java IPC implementations found. The implementation of IPC using JGroups is shown, including a code example. With results showing a 36 percent reduction in memory usage and a four times improvement in receipt and storage of DICOM C-Store images.
CONTOUR-BASED FEATURE EXTRACTION USING DUAL-TREE COMPLEX WAVELETS (2007)

A contour-based feature extraction method is proposed by using the dual-tree complex wavelet transform and the Fourier transform. Features are extracted from the 1D signals r and θ, and hence the processing memory and time are reduced. The approximate shift-invariant property of the dual-tree complex wavelet transform and the Fourier transform guarantee that this method is invariant to translation, rotation and scaling. The method is used to recognize aircrafts from different rotation angles and scaling factors. Experimental results show that it achieves better recognition rates than that which uses only the Fourier features and Granlund's method. Its success is due to the desirable shift invariant property of the dual-tree complex wavelet transform, the translation invariant property of the Fourier spectrum, and our new complete representation of the outer contour of the pattern.