gebhart/patrepeval huggingface dataset:
Inhibition of Poly(ADP-ribose) Polymerase-1 by Arsenite Interferes with Repair of Oxidative DNA Damage (2008)

Arsenic enhances skin tumor formation when combined with other carcinogens, including UV radiation (UVR). In this study we report that low micromolar concentrations of arsenite synergistically increases UVR-induced oxidative DNA damage in human keratinocytes as detected by 8-hydroxyl-2'-deoxyguanine (8-OHdG) formation. Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in base excision repair, a process that repairs 8-OHdG lesions. Arsenite suppresses UVR-induced PARP-1 activation in a concentration-dependent manner. Inhibition of PARP-1 activity by 3-aminobenzamide or small interfering RNA silencing of PARP-1 expression significantly increases UVR-induced 8-OHdG formation, suggesting that inhibition of PARP-1 activity by arsenite contributes to oxidative DNA damage. PARP-1 is a zinc finger protein, and mass spectrometry analysis reveals that arsenite can occupy a synthetic apopeptide representing the first zinc finger of PARP-1 (PARPzf). When the PARPzf peptide is preincubated with Zn(II) followed by incubation with increasing concentrations of arsenite, the ZnPARPzf signal is decreased while the AsPARPzf signal intensity is increased as a function of arsenite dose, suggesting a competition between zinc and arsenite for the same binding site. Addition of Zn(II) abolished arsenite enhancement of UVR-stimulated 8-OHdG generation and restored PARP-1 activity. Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite. Arsenite inhibition of poly(ADP-ribosyl)ation is one likely mechanism for the reported co-carcinogenic activities of arsenic in UVR-induced skin carcinogenesis.
A wavelet-based multiresolution polyhedral object representation (1997)

No abstract available.
태양열원을 이용하는 소규모 해수담수 발생장치의 성능 예측기법에 관한 실험적 연구 (2018)

물은 인류의 생존에 필수이지만 아직도 물의 공급이 원활하지 않은 지역은 존재하고 있으며, 물의 공급이 원활하지 않은 곳은 깨끗한 물을 생산하기 위한 에너지의 공급 역시 어려운 것이 현실이다. 본 연구에서는 청정에너지원인 태양열을 이용한 담수발생장치 및 다양한 물공급 상황 변화에 대응하기 위해 병렬구성이 가능한 소형 담수화 시스템을 개발하고 시스템의 성능평가를 위한 주요 변수인 담수화 시스템의 형상과 태양열로 가열된 담수의 온도를 주요 변인으로 하여 시스템의 성능에 미치는 영향을 평가하였다. 이를 위하여 실측실험을 통해 소형 담수화 시스템의 실험장치를 구성하고 태양열의 축열 온도 및 담수발생 장치의 형상에 따른 담수생산량 데이터를 획득하였으며 추가 연구를 위한 상관식을 제안하였다.
Efficient Separation of Dyes by Mucin: Toward Bioinspired White‐Luminescent Devices (2011)

Nature's ability to form stable and controllable host-guest systems is exploited to construct a new type of robust matrix biomaterial, which is used for the formation of protein luminescent films and devices. This simple methodology involves the extraordinary capabilities of mucin proteins to host hydrophobic dyes. It is shown that large variety of luminescent films can be formed.<?br?>
Role of a Class Dhc1b Dynein in Retrograde Transport of Ift Motors and Ift Raft Particles along Cilia, but Not Dendrites, in Chemosensory Neurons of Living <i>Caenorhabditis elegans</i> (1999)

The heterotrimeric motor protein, kinesin-II, and its presumptive cargo, can be observed moving anterogradely at 0.7 microm/s by intraflagellar transport (IFT) within sensory cilia of chemosensory neurons of living Caenorhabditis elegans, using a fluorescence microscope-based transport assay (Orozco, J.T., K.P. Wedaman, D. Signor, H. Brown, L. Rose, and J.M. Scholey. 1999. Nature. 398:674). Here, we report that kinesin-II, and two of its presumptive cargo molecules, OSM-1 and OSM-6, all move at approximately 1.1 microm/s in the retrograde direction along cilia and dendrites, which is consistent with the hypothesis that these proteins are retrieved from the distal endings of the cilia by a retrograde transport pathway that moves them along cilia and then dendrites, back to the neuronal cell body. To test the hypothesis that the minus end-directed microtubule motor protein, cytoplasmic dynein, drives this retrograde transport pathway, we visualized movement of kinesin-II and its cargo along dendrites and cilia in a che-3 cytoplasmic dynein mutant background, and observed an inhibition of retrograde transport in cilia but not in dendrites. In contrast, anterograde IFT proceeds normally in che-3 mutants. Thus, we propose that the class DHC1b cytoplasmic dynein, CHE-3, is specifically responsible for the retrograde transport of the anterograde motor, kinesin-II, and its cargo within sensory cilia, but not within dendrites.
Evolutionary trends in Transmit/Receive Module for Active Phased Array Radars (2018)

<p>Worldwide, defense technologies are rapidly evolving and are currently aiming at integrating diverse functionalities like Radar, Electronic Warfare, Communications, etc., on a singular miniaturized platform. Hence, it cannot be denied that the advancements in modern Active Phased Array Radar technologies assume a critical role towards the achievement of this goal. A typical Active Phased Array Radar comprises of an Active Antenna Array Unit (AAAU) consisting of a large number of radiating elements, Transmit/Receive (T/R) Modules with other associated RF and digital circuitry and power electronics. This paper presents mainly the developments in Transmit/Receive (T/R) Module technology, which assimilates various stages of the technological evolution - past, current and futuristic. It discusses how these technologies contribute towards the improvement of efficiency, miniaturization and reliability without compromising its performance parameters.</p>
Gravity interpretation using the fourier integral; discussion and reply (1975)

Abstract In their paper, Odegard and Berg claim that from the gravity anomaly due to a two-dimensional vertical fault the density, the throw, and the depth can be determined uniquely by a Fourier transform method. It is true that the solution of the reverse problem for a two-dimensional vertical step is theoretically unique. The derivation of the Fourier transform by the authors, however, is erroneous.
Use of cyclic carbonate oligomers in the synthesis of bisphenol‐a polycarbonate‐polydimethylsiloxane copolymers (1991)

Abstract Polydimethylsiloxane‐polycarbonate block copolymers were prepared by sequential anionic polymerizations of cyclic carbonate oligomers and octamethylcyclotetrasiloxane, or by reaction of hydroxy‐terminated polydimethylsiloxane oligomers with cyclic carbonates or by reaction of hydroxy‐terminated polycarbonate oligomers (derived from cyclic carbonates) with chlorine‐terminated polydimethylsiloxane oligomers. The use of cyclic carbonates for making the copolymers afforded a synthetic flexibility not available through conventional methods involving phosgene.
The antimicrobial activity of garlic and onion extracts. (1983)

Aqueous extracts of garlic (Allium sativum) and onion (Allium cepa) were tested for activity against Gram-positive organisms, Gram-negative organisms and fungi. A significant growth inhibition was shown by most of the organisms, tested at random. A quantitative assessment of the activity was carried out by determining the minimum bacteriostatic and bactericidal concentrations of the extracts against Gram-positive and Gram-negative organisms. Garlic extract showed greater activity as compared to the extract of onion. The activity of the garlic extract on the mouth flora of volunteers was then investigated. A mouth wash containing 10% garlic in quarter Ringer solution produced a drastic reduction in the number of oral bacteria.
Illness in horses following spraying with amitraz (1984)

Sickness occurred in 3 of 4 horses within 24 h of being sprayed with an 0.025% w/v aqueous suspension of amitraz. The latter consisted of a portion of an amitraz aqueous suspension made up some 3 weeks previously, to which some freshly prepared spray fluid had been added. It seemed likely that the amitraz in the older solution had broken down to the highly toxic N-3, 5- dimethylphenyl N-methyl formamadine derivative and that this was in fact the main cause of the untoward effects observed. The horses displayed typical clinical signs of tranquillisation, depression, ataxia, muscular incoordination and impaction colic lasting up to 6 days. Subcutaneous oedema of the face occurred in one horse. The syndrome was accompanied by mild dehydration and acidosis. All horses survived after persistent symptomatic treatment including the giving of intravenous fluids, enemas, analgesics every 3 h, multiple doses of paraffin oil per os and dexamethasone intravenously. Following the eventual relief of constipation the horses scoured profusely for 24 h before their condition returned to normal.
<i>In Vivo</i> Dog Intestinal Precipitation of Mebendazole: A Basic BCS Class II Drug (2012)

The purpose of this study was to investigate in vivo intestinal precipitation of a model drug mebendazole, a basic BCS class II drug, using dogs with intestinal stomas for administration or sampling. After oral administration of a solution with an expected intestinal supersaturation of approximately 20 times the solubility, the measured supersaturation in dog intestinal fluid (DIF) was up to 10 times and, on average, only 11% of the given dose was retrieved as solid drug in the collected fluid from the stoma. The drug was rapidly absorbed with >90% of the total systemic exposure reached within three hours after duodenal administration of a solution. In silico absorption modeling showed that in vivo data were reasonably well described by a nonprecipitating solution. An in vitro model of precipitation in DIF predicted that the intestinal concentration of dissolved mebendazole would be less than 1/5 of the initial concentration within 10 min at concentrations comparable to in vivo. It was concluded that intestinal precipitation did not have any major influence on mebendazole absorption. The extent of precipitation was overpredicted in vitro given the in vivo absorption rate, and further work is needed to identify in vitro factors that could enable more accurate in vivo predictions of intestinal precipitation from solutions.
Derivatives of 5-phenyl-2,4-pentadienoic acid as potential antimalarial agents (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDerivatives of 5-phenyl-2,4-pentadienoic acid as potential antimalarial agentsLeslie M. Werbel, Nancy Headen, and Edward F. ElslagerCite this: J. Med. Chem. 1968, 11, 5, 1073–1074Publication Date (Print):September 1, 1968Publication History Published online1 May 2002Published inissue 1 September 1968https://pubs.acs.org/doi/10.1021/jm00311a039https://doi.org/10.1021/jm00311a039research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Perth Rainfall IFD Revisited (1996)

To assist Urban Stormwater Design and Management in Perth a preliminary review of the rainfall intensity frequency duration (IFD) statistics was performed. The review was prompted by the highest rainfall on record for durations between 4 and 21 hours on 8th and 9th February 1992, and the effect this went may have on the published statistics which are based on rainfall data generally up to 1986. Frequency analysis of Perth Airport data extending from 1945 and other shorter record stations was performed. There is a case for thorough reassessment of the published IFD both in light of the February 1992 storm and the greater number of pluviograph stations with record lengths exceeding the minimum of 12 years used to determine the published IFD.
Production of Asphalt-Rubber Binders by High-Cure Conditions (1997)

A curing study was undertaken to determine the effect that asphalt composition, rubber content, rubber mesh size, curing time, curing temperature, and rate of mixing have on asphalt-rubber properties. Curing temperatures of 232°C or 260°C (450°F or 500°F) and a high-shear laboratory mixer were used to produce the asphalt-rubber blends. The properties studied were rubber dissolution; rubber settling; molecular weight distribution; and low-, intermediate-, and high-temperature rheological properties. Increasing the curing temperature from 232°C to 260°C (450°F to 500°F) drastically increased the rate of devulcanization and depolymerization of the rubber, whereas increasing the rate of mixing from 4,000 rpm to 8,000 rpm drastically decreased the settling rate of rubber in a binder. Lower-molecular-weight asphalts were better at devulcanizing the rubber; higher-molecular-weight asphalts were better at depolymerizing the rubber. These high-cure binders are homogeneous in appearance and slow to phase separate on standing; they have acceptable compaction viscosities at hot-mix temperatures, higher G*/sinδ at rutting temperatures, and lower stiffness at cold temperatures than does the base asphalt.
Antigen Presentation by an Immature Myeloid Dendritic Cell Line Does Not Cause CTL Deletion In Vivo, but Generates CD8+ Central Memory-Like T Cells That Can Be Rescued for Full Effector Function (2005)

Immature dendritic cells (DC), in contrast to their mature counterparts, are incapable of mobilizing a CD8+ CTL response, and, instead, have been reported to induce CTL tolerance. We directly addressed the impact of immature vs mature DC on CTL responses by infusing adenovirus peptide-loaded DC (of the D1 cell line) into mice that had received adenovirus-specific naive TCR-transgenic CD8+ T cells. Whereas i.v. injection of mature DC triggered vigorous CTL expansion, immature DC elicited little proliferation involving only a minority of the TCR-transgenic CTL. Even though the latter CTL developed effector functions, including cytolytic activity and proinflammatory cytokine secretion, these cells differed significantly from CTL primed by mature DC in that they did not exhibit down-regulation of CD62L and CCR7, receptors involved in trapping of T cells in the lymphoid organs. Interestingly, adoptive transfer of CTL effector cells harvested after priming by either mature or immature DC into naive recipient mice, followed by exposure to adenovirus, yielded quantitatively and qualitatively indistinguishable CTL memory responses. Therefore, in vivo priming of naive CD8+ T cells by immature DC, although failing to induce a full-blown, systemic CTL response, resulted in the formation of central memory-like T cells that were able to expand and produce IFN-gamma upon secondary antigenic stimulation.
Local laser cooling of Yb:YLF to 110 K (2011)

Minimum achievable temperature of ~110 K is measured in a 5% doped Yb:YLF crystal at λ = 1020 nm, corresponding to E4-E5 resonance of Stark manifold. This measurement is in excellent agreement with the laser cooling model and was made possible by employing a novel and sensitive implementation of differential luminescence thermometry using balanced photo-detectors.
A ribbon-like ultramicroporous conjugated polycarbazole network for gas storage and separation (2015)

Ribbon-like ultramicroporous conjugated polycarbazole network P-TCzTAT was synthesized having high BET surface area and narrow pore width distribution.
NEW YORK STATE SCIENCE TEACHERS‘ ASSOCIATION (1916)

The seventieth annual meeting of the New York State Teachers' Association was held in Rochester, N. Y
A Study on Configurations of Casing Treatment for Axial Flow Compressors (1984)

Casing treatment is known to improve the stall margin of axial compressors. However, it is known as well that casing treatment lowers the efficiency of compressors. An experiment was planned in order to test a series of configurations of casing treatment which are supposed to have favourable effects and to obtain the optimum ones, if any, judged from above-mentioned two standpoints: larger stall margin improvement and smaller lowering of efficiency. The result shows that the relation between the stall margin imp improvement and the compressor efficiency for all of the tested configurations falls on some smooth curved-line, and thus, there exists no particularly superior treatment configuration to others. It rather shows that a certain amount of loss in efficiency is inevitable in order to obtain the required amount of stall margin improvement. Influence of rotor tip clearance on the effect of casing treatment was also examined. The result can be used as a guide for the selection of configurations in designing the casing treatment.
CBA: Contextual Quality Adaptation for Adaptive Bitrate Video Streaming (Extended Version) (2019)

Recent advances in quality adaptation algorithms leave adaptive bitrate (ABR) streaming architectures at a crossroads: When determining the sustainable video quality one may either rely on the information gathered at the client vantage point or on server and network assistance. The fundamental problem here is to determine how valuable either information is for the adaptation decision. This problem becomes particularly hard in future Internet settings such as Named Data Networking (NDN) where the notion of a network connection does not exist. In this paper, we provide a fresh view on ABR quality adaptation for QoE maximization, which we formalize as a decision problem under uncertainty, and for which we contribute a sparse Bayesian contextual bandit algorithm denoted CBA. This allows taking high-dimensional streaming context information, including client-measured variables and network assistance, to find online the most valuable information for the quality adaptation. Since sparse Bayesian estimation is computationally expensive, we develop a fast new inference scheme to support online video adaptation. We perform an extensive evaluation of our adaptation algorithm in the particularly challenging setting of NDN, where we use an emulation testbed to demonstrate the efficacy of CBA compared to state-of-the-art algorithms.
Colposcopy Text and Atlas (1990)

Tissue basis of colposcopy instrumentation and biopsy techniques the normal cervix normal transformation zone a typical transformation zone cervical intra-epithelial neoplasa colposcopy of micro-invasive and invasive cancer of the cervix cytohistopathology and colposcopy of the vagina cytohistophatology and colposcopy of the vulva human papilloma virus colposcopy and pregnancy cytohistopathology and colposcopy of the DES-exposed female common errors of colposcopy and cytology cervicography.
On the Performance Improvement of a Cellular Network Supported by an Unmanned Aerial Base Station (2017)

This paper studies a cellular network, where base stations move according to traffic/service needs; coverage and capacity offered are adaptive to the time-spatial variations of user demand. In particular, we analyze the performance of a network, where a base station is carried by a UAV (Unmanned Aerial Vehicle, sometimes also denoted as drone). The Unmanned Aerial Base Station (UABS) flies over an urban area, offering coverage and capacity to users that are not served by the Terrestrial Base Stations (TBSs); in our scenario we consider in particular video users with stringent requirements in terms of downlink throughput. The paper proposes an approach to design the trajectory of the drone, that accounts for the actual position of users that are unsatisfied by the TBSs. The approach is based on the identification of clusters made of nearby users to be served, and a simple Nearest Neighbor algorithm. The potential improvements in terms of network capacity (sum throughput) and user satisfaction are estimated, in a scenario where the UABS uses a separate band with respect to the TBSs. This performance increase can be seen as an upper bound to the improvements that would be achieved by using the same band, where the UABS would actually interfere with the TBSs.
Determination of End-points for Polymorph Conversions of Crystalline Organic Compounds Using On-line Near-infrared Spectroscopy (1997)

Trovafloxacin mesylate exists in two anhydrous polymorphic forms, I and II. The fundamental band vibration spectra information does not readily differentiate between the two forms, although the crystal lattice of each form has a distinct X-ray powder diffraction pattern. Subtle spectral differences between the two polymorphs can be detected in the NIR spectral region and the interconversion of the two forms can be monitored in hot solvent crystal slurries using NIR spectroscopy and an on-line fibre optic probe. A generally applicable method has been developed to monitor the conversion of form I into form II as a crystal slurry. The free energy profile in principal component space has been modelled as the process proceeds to give a computer graphic of the change which readily shows when the conversion is complete.
High-Temperature Microphone With Fiber-Optic Output (1994)

Acoustic-pressure transducer (microphone) with fiber-optic output designed to withstand hot, loud, structurally vibrating environment like that of jet engine. Features flat frequency response out to frequencies well beyond several-kilohertz range needed to test for acoustic-pressure loads on engine structures.
Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time (2020)

Histone methyltransferase EZH2, which is the catalytic subunit of the PRC2 complex, catalyzes the methylation of histone H3K27-a transcriptionally repressive post-translational modification (PTM). EZH2 is commonly mutated in hematologic malignancies and frequently overexpressed in solid tumors, where its expression level often correlates with poor prognosis. First generation EZH2 inhibitors are beginning to show clinical benefit, and we believe that a second generation EZH2 inhibitor could further build upon this foundation to fully realize the therapeutic potential of EZH2 inhibition. During our medicinal chemistry campaign, we identified 4-thiomethyl pyridone as a key modification that led to significantly increased potency and prolonged residence time. Leveraging this finding, we optimized a series of EZH2 inhibitors, with enhanced antitumor activity and improved physiochemical properties, which have the potential to expand the clinical use of EZH2 inhibition.
Characterization of oxygen-linked glucuronides by laser desorption mass spectrometry (1984)

A laser desorption time-of-flight mass spectrometer is used for structural confirmation of several acyl- and ether-linked glucuronides. Abundant molecular ion species are produced, as well as fragmentation reflecting both the molecular structure and the stability of the conjugates. The major ions are produced by cationization, and detection limits are as low as 1.6 ng (5.0 pmol).