gebhart/patrepeval huggingface dataset:
A first-in-human study of the novel metabolism-based anti-cancer agent SM-88 in subjects with advanced metastatic cancer (2019)

Purpose SM-88 (D,L-alpha-metyrosine; racemetyrosine) is a novel anti-cancer agent, used with melanin, phenytoin, and sirolimus (SMK Therapy). This pilot first-in-human study characterized the safety, tolerability, and efficacy of SMK Therapy in subjects with advanced metastatic cancer. Methods All subjects (n = 30) received SMK Therapy for an initial 6 week Cycle (5 days on, 2 off per week) and continued if well tolerated. Safety signals, clinical response, overall survival, progression free survival (PFS), and quality of life changes were assessed. Results The most common drug related adverse events were hyperpigmentation and rash. All drug related adverse events were mild to moderate in intensity. Following treatment with SMK Therapy, 4 subjects achieved complete response, 6 partial response, and 17 stable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 (total clinical benefit 90%). Responses were observed within 6 weeks, and continued to improve, with 3 complete and 3 partial responders achieving best response after at least 3.2 months. Durable stable disease was observed, lasting a median duration of 11 months (range 1-31 months). Median overall survival for all subjects was 29.8 months, and median PFS was 13 months. Following 6 weeks of treatment, most (83.3%) subjects showed an improvement in Eastern Cooperative Oncology Group (ECOG) score and an improvement in the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ 30) global health status (baseline 61.2 ± 25.0; end of Cycle 1 80.7 ± 14.7; n = 29; p < 0.001). Conclusions The results of this study support continued development of SM-88.
Crucial Transcription Factors in Endoderm and Embryonic Gut Development Are Expressed in Gut-Like Structures from Mouse ES Cells (2005)

Mouse embryonic stem (ES) cells are pluripotent and retain the potential to form an organ similar to the gut showing spontaneous contractions in vitro. The morphological features of these structures and their formation, as assessed using the hanging drop method to produce embryoid bodies (EBs), seem to be similar to those in vivo. To determine whether the same molecular mechanisms are involved in the formation process, the expression pattern of transcription factors regulating endoderm and gut development in the mouse embryo was examined by in situ hybridization and compared with in vivo expression. Expression of gene products was also examined by immunohistochemistry, and expression colocalization was analyzed with double staining. The results showed that all factors examined, that is, Sox17, Id2, HNF3beta/Foxa2, and GATA4, were expressed in both EBs and gut-like structures. Moreover, their expression patterns were similar to those in the mouse embryo. EBs after the hanging drop period and before outgrowth already expressed all factors that were colocalized with each other in EB epithelial structures. These findings suggest that the origin of the gut-like structure is determined during the hanging drop period and that the gut-like structure is formed as the epithelial structure in EBs during the hanging drop period. They also indicate that the in vitro system using mouse ES cells mimics in vivo development and should prove useful in the study of molecular mechanisms for endoderm and gut development.
Imidoyl azide to tetrazole cyclization limited by internal hydrogen bonding and imine isomerization (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImidoyl azide to tetrazole cyclization limited by internal hydrogen bonding and imine isomerizationAnthony F. Hegarty and Edward P. AhernCite this: J. Org. Chem. 1981, 46, 7, 1342–1346Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/jo00320a022https://doi.org/10.1021/jo00320a022research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of a business process modeling methodology and a tool for sharing business processes (2005)

Sharing know-how regarding business process modeling activities and best practices can save time in the early phases of business system development. To help developers share know-how and best practices, we have developed a methodology and a tool for business process modeling and have applied it to a system development project. Furthermore, we have developed process-template development techniques to realize granularity-unification of business processes so that business process models can be reused, and have clarified the practical divisions of process models and the design issues concerning each division. These techniques enable the preparation of reuse-oriented business process templates before the business process modeling activity. In this paper, we describe the methodology and tool, including a meta-model and notations we have constructed for business modeling. We then consider the effectiveness of the methodology and tool: in an actual development project, the tool and business process templates decreased development time by 46% or more.
Regulatory T Cells Accumulate and Proliferate in the Ischemic Hemisphere for up to 30 Days after MCAO (2012)

Local and peripheral immune responses are activated after ischemic stroke. In our present study, we investigated the temporal distribution, location, induction, and function of regulatory T cells (Tregs) and the possible involvement of microglia, macrophages, and dendritic cells after middle cerebral artery occlusion (MCAO). C57BL/6J and Foxp3(EGFP) transgenic mice were subjected to 30 minutes MCAO. On days 7, 14, and 30 after MCAO, Tregs and antigen presenting cells were analyzed using fluorescence activated cell sorting multicolor staining and immunohistochemistry. A strong accumulation of Tregs was observed on days 14 and 30 in the ischemic hemisphere accompanied by the elevated presence and activation of microglia. Dendritic cells and macrophages were found on each analyzed day. About 60% of Foxp3(+) Tregs in ischemic hemispheres were positive for the proliferation marker Ki-67 on days 7 and 14 after MCAO. The transfer of naive CD4(+) cells depleted of Foxp3(+) Tregs into RAG1(-/-) mice 1 day before MCAO did not lead to a de novo generation of Tregs 14 days after surgery. After depletion of CD25(+) Tregs, no changes regarding neurologic outcome were detected. The sustained presence of Tregs in the brain after MCAO indicates a long-lasting immunological alteration and involvement of brain cells in immunoregulatory mechanisms.
Comparison of Fatigue Lives Under Conventional Program Loading and Digital Random Loading (1970)

On the basis of a gust-load distribution, evaluated by applying level crossing-counting method, an 8-step program test and tests with a random sequence of stress cycles were performed. The results of these tests are compared with the results of tests with a random sequence of maxima and minima. The latter are based on a distribution of maxima and minima, which were derived from the gust-load distribution splitted in several stationary Gaussian processes. In further tests, ground-air-ground cycles were included in the study. Programmed and randomized flight-by-flight tests were compared. The results of the study revealed that in the case of steady mean stress and the applied conditions program loading overestimates life by a factor of about 6. In case of flight-by-flight tests, however, the load-time history (either programmed or randomized) seem to be unimportant.
Synthetic Studies by the Use of Carbonates. I. The Nucleophilic Substitution Reaction of Ethylene Carbonate with Amine Hydrohalides (1974)

Abstract The reaction of ethylene carbonate with various amine hydrohalides gave the corresponding quaternary ammonium salts of β-hydroxyethylamines in good yields.
A new approach to fault-tolerant wormhole routing for mesh-connected parallel computers (2004)

A new method for fault-tolerant wormhole routing in arbitrary dimensional meshes is introduced. The method was motivated by certain routing requirements of an initial design of the Blue Gene supercomputer at IBM Research. The machine is organized as a three-dimensional mesh containing many thousands of nodes and the routing method should tolerate a few percent of the nodes being faulty. There has been much work on routing methods for meshes that route messages around faults or regions of faults. The new method is to declare certain nonfaulty nodes to be "lambs." A lamb is used for routing but not processing, so a lamb is neither the source nor the destination of a message. The lambs are chosen so that every "survivor node," a node that is neither faulty nor a lamb, can reach every survivor node by at most two rounds of dimension-ordered (such as e-cube) routing. An algorithm for finding a set of lambs is presented. The results of simulations on 2D and 3D meshes of various sizes with various numbers of random node faults are given. For example, on a 32 /spl times/ 32 /spl times/ 32 3D mesh with 3 percent random faults and using at most two rounds of e-cube routing for each message, the average number of lambs is less than 68, which is less than 7 percent of the number 983 of faults and less than 0.21 percent of the number 32,768 of nodes.
Robust super-resolution for interactive video navigation (2012)

One of the main technical limitations in interactive systems for next-generation audio-visual experiences is the limited resolution of the captured contents. The presented method tackles the problem of generating super-resolved versions of input video frames, thus allowing the user to visualize the captured visual contents at any desired scale with minimal degradation. First, the low-frequency band of the super-resolved video frame is estimated as an up-scaled interpolation of the low-resolution frame. Then, the high-frequency band is extrapolated from the low-resolution frame by exploiting local cross-scale self-similarity. The introduction of a suitable image prior in both stages allows to robustly enhance the spatial resolution even in video sequences containing aliasing. The most demanding processing stages of the presented algorithm have been implemented on graphics hardware (GPU). The experimental results show a level of quality similar to that of state-of-the-art methods, with the advantages of real-time processing and robustness against spatial aliasing.
Polymorphism and type inference in database programming (1996)

In order to find a static type system that adequately supports database languages, we need to express the most general type of a program that involves database operations. This can be achieved through an extension to the type system of ML that captures the polymorphic nation of field selection, together with a techniques that generalizes relational operators to arbitrary data structures. The combination provides a statically typed language in which generalized relational databases may be cleanly represented as typed structures. As in ML types are inferred, which relieves the programmer of making the type assertions that may be required in a complex database environment. These extensions may also be used to provide static polymorphic typechecking in object-oriented languages and databases. A problem that arises with object-oriented databases is the apparent need for dynamic typechecking when dealing queries on heterogeneous collections of objects. An extension of the type system needed for generalized relational operations can also be used for manipulating collections of dynamically typed values in a statically typed language. A prototype language based on these ideas has been implemented. While it lacks a proper treatment of persistent data, it demonstrates that a wide variety of database structures can be cleanly represented in a polymorphic programming language.
Characterization of the Interaction between the Interferon-Induced Protein P56 and the Int6 Protein Encoded by a Locus of Insertion of the Mouse Mammary Tumor Virus (2000)

For determining cellular functions of the interferon-inducible human cytoplasmic protein P56, we undertook a Saccharomyces cerevisiae two-hybrid screen that identified Int6 as a P56-interacting protein. That the interaction also occurs in human cells was confirmed by coimmunoprecipitation and the observed cytoplasmic displacement of nuclear Int6 upon coexpression of P56. Because Int6 has been claimed to be both a cytoplasmic and a nuclear protein, we investigated the structural basis of this discrepancy. By mutational analyses, we showed that the Int6 protein contains a bipartite nuclear localization signal and a nuclear export signal at the far end of the amino terminus. The 20 amino-terminal residues of Int6, when they were attached to a different nuclear protein, were sufficient to translocate that protein to the cytoplasm. Within this region, replacement of any of the three leucine residues with alanine destroyed the function of the export signal. The specific domain of P56 that is required for its interaction with Int6 was mapped using the yeast two-hybrid assay and a mammalian coimmunoprecipitation assay. Both assays demonstrated that the C-terminal region of P56 containing three specific tetratricopeptide motifs is required for this interaction. In contrast, removal of an internal domain of P56 enhanced the interaction, as quantified by the two-hybrid assay.
D3NOC: Dynamic Data-Driven Network On Chip in Photonic Electronic Hybrids (2017)

In this paper, we present a reconfigurable hybrid Photonic-Plasmonic Network-on-Chip (NoC) based on the Dynamic Data Driven Application System (DDDAS) paradigm. In DDDAS computations and measurements form a dynamic closed feedback loop in which they tune one another in response to changes in the environment. Our proposed system enables dynamic augmentation of a base electrical mesh topology with an optical express bus during the run-time. In addition, the measurement process itself adjusts to the environment. In order to achieve lower latencies, lower dynamic power, and higher throughput, we take advantage of a Configurable Hybrid Photonic Plasmonic Interconnect (CHyPPI) for our reconfigurable connections. We evaluate the performance and power of our system against kernels from NAS Parallel Benchmark (NPB) in addition to some synthetically generated traffic. In comparison to a 16x16 base electrical mesh, D3NOC shows up to 89% latency and 67% dynamic power net improvements beyond overhead-corrected performance. It should be noted that the design-space of NoC reconfiguration is vast and the goal of this study is not design-space exploration. Our goal is to show the potentials of adaptive dynamic measurements when coupled with other reconfiguration techniques in the NoC context.
Robust image compression based on self-synchronizing Huffman code and inter-subband dependency (2002)

An improved self-synchronizing Huffman code is proposed to decrease the error propagation length in the compressed bit stream caused by errors during transmission. After regaining synchronization, the decoder may still not be able to align each symbol with its correct location due to the wrong number of previously decoded symbols in the error propagation region. A scheme to identify the probable error location and then move symbols towards their correct positions is also proposed by exploiting the correlation between coefficients of the current subband and their parent subband. Experiments under different error conditions are performed, and it is demonstrated that the proposed error resilient techniques provide a more robust codec with very little sacrifice in the coding efficiency.
Cognitive Function in Patients With Multiple Sclerosis (1980)

The performance of patients with multiple sclerosis on selected psychological tests was examined to ascertain the usefulness of such examinations to diagnosis. Cognitive impairment was studied in relationship to disease-related factors, physician's identification of cerebral involvement, and psychological adjustment. The results indicate that half the subjects exhibited cognitive impairment. Levels of neurologic involvement, physical impairment, and depression were not predictive of cognitive impairment. Of the subjects who were judged on neurological examination to have intact mentation, half were actually impaired. Impaired cognitive functioning, which is often not detected through routine examination, may occur early in the disease. These deficits may represent manifestations of otherwise undetectable plaques in the subcortical white matter.
Active microring and microdisk optical resonators on indium phosphide (2006)

Photonic or optical logic holds the promise of ultra-fast logic circuits with capability for speeds beyond what is possible using conventional silicon electronics. However, the jump from theory to practice has a high barrier set by critical issues such as integration, scalability and power requirements. Optical micro-resonator based schemes have the potential of addressing some of these issues. This thesis focuses on the development of active InGaAsP/InP microdisk and microring optical resonators to lower that barrier a little. Microrings and disks provide a compact and cascadable device platform to achieve resonance enhancement of optical non-linearity. By incorporating gain in such devices, the optical power needed for carrying out switching can be greatly reduced. Electrically pumped microring and microdisk resonators are fabricated on indium phosphide in both vertically and laterally coupled bus-waveguide configurations. The gain saturation non-linearity is used to demonstrate all-optical switching and bistable operation at optical powers more than two orders of magnitude lower compared to passive devices. The shift in the ring/disk resonances caused by the refractive index change due to a pump beam is used to switch a weaker probe beam tuned to one of the resonances. The non-linear response and switching mechanism is modeled numerically. A novel pseudodisk configuration that combines the best of microdisks and microrings is used to minimize device heating and surface recombination as well as provide near single-mode operation. Additionally, optical amplifiers based on microrings are also developed for cascading passive optical gates. Optical amplification up to 10 db in pulsed mode has been observed for 20 µm radius microrings. The control of surface recombination on the microring sidewalls is critical to avoid carrier loss and device heating. A sulfur passivation scheme is used to reduce the surface recombination velocity. The lateral carrier transport and surface recombination in microrings is analyzed by an ambipolar diffusion model.
[Active drainage of a wound]. (1987)

Experimental investigations of the authors have shown active drainage to be optimal at negative pressure in the wound not higher than 80 mm Hg. The application of active drainage in the treatment of 1369 patients has demonstrated the effectiveness of the method for prevention of local complications of the wound process.
Stability of queueing networks and scheduling policies (1995)

We develop a programmatic procedure for establishing the stability of queueing networks and scheduling policies. The method uses linear or nonlinear programming to determine what is an appropriate quadratic functional to use as a Lyapunov function. If the underlying system is Markovian, our method establishes not only positive recurrence and the existence of a steady-state probability distribution, but also the geometric convergence of an exponential moment. We illustrate this method on several example problems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Bovine salmonellosis (1977)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Synthesis of phosphine oxides from phosphorus esters and alkyl halides using either sodium bis(2-methoxyethoxy) aluminum hydride or sodium aluminum diethyl dihydride (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of phosphine oxides from phosphorus esters and alkyl halides using either sodium bis(2-methoxyethoxy) aluminum hydride or sodium aluminum diethyl dihydrideRonald B. Wetzel and George L. KenyonCite this: J. Org. Chem. 1974, 39, 11, 1531–1535Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://pubs.acs.org/doi/10.1021/jo00924a017https://doi.org/10.1021/jo00924a017research-articleACS PublicationsRequest reuse permissionsArticle Views338Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Pulsed‐Gradient Spin‐Echo ESR (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Deposition Characteristics of Metal Contaminants from  HF  ‐ Based Process Solutions onto Silicon Wafer Surfaces (1992)

Metal contamination levels are a growing concern in integrated circuit manufacturing because they degrade electrical performance. This work uses statistical design of experiments to determine deposition characteristics of metal contaminants onto silicon surfaces from process chemicals that are used in wafer cleaning. Copper, gold, molybdenum, silver, lead, chromium, tin, titanium, manganese, and tungsten were added to buffered oxide etchant and solutions. Wafers were immersed in these solutions and evaluated by total reflectance x‐ray fluorescence spectroscopy surface analysis. Most contaminant deposition characteristics are simple, dependent on bath type and contamination level alone. Some contaminant deposition characteristics are complex, dependent on multifactors including bath type, contaminant level, and the presence of other contaminants as well.