gebhart/patrepeval huggingface dataset:
Carbamate ester latentiation of physiologically active amines (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbamate ester latentiation of physiologically active aminesLeo G. Abood and Anthony J. VerbiscarCite this: J. Med. Chem. 1970, 13, 6, 1176–1179Publication Date (Print):November 1, 1970Publication History Published online1 May 2002Published inissue 1 November 1970https://pubs.acs.org/doi/10.1021/jm00300a035https://doi.org/10.1021/jm00300a035research-articleACS PublicationsRequest reuse permissionsArticle Views358Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular Forces and Solvent Power. (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular Forces and Solvent Power.R. G. Larson and Herschel. HuntCite this: J. Phys. Chem. 1939, 43, 4, 417–423Publication Date (Print):April 1, 1939Publication History Published online1 May 2002Published inissue 1 April 1939https://doi.org/10.1021/j150391a003RIGHTS & PERMISSIONSArticle Views253Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (321 KB) Get e-Alerts
Synthesis and Structural Investigation of Tungsten Imido Amidinate and Guanidinate Complexes (2005)

The tungsten imido guanidinate and amidinate complexes W(NR)Cl(3)[R'NC(NMe(2))NR'] and W(NR)Cl(3)[R'NC(Me)NR'] (R = Ph, (i)Pr, Cy; R' = (i)Pr, (t)Bu, TMS) were synthesized by reacting the corresponding imido complex W(NR)Cl(4)(OEt(2)) with the appropriate lithium amidinate or guanidinate. Crystallographic structure determination of W(N(i)Pr)Cl(3)[(i)PrNC(NMe(2))N(i)Pr] and W(N(i)()Pr)Cl(3)[(i)PrNC(Me)N(i)Pr] allows comparison of structural features between the guanidinate and amidinate ligand in the presence of an identical ancillary ligand set.
The biochemical modes of action of vitamin e and selenium: A hypothesis (1973)

In this paper recent experimental work on rat liver is discussed which is considered to indicate that a primary function of vitamin E in vivo may be to inhibit the oxidation of selenide-containing proteins present in mitochondria and in smooth endoplasmic reticulum. On the basis of molecular model building studies, it is also suggested that the well-known nutritional relationships between vitamin E and dietary polyunsaturated lipids may be due to the occurrence within normal membranes of specific complexes between the vitamin and some of the molecules of polyunsaturated phospholipids. Without the vitamin, membranes may have an abnormally high permeability and they may be subject to degradation by endogenous phospholipases in vivo, as well as being abnormally susceptible to damage in vitro by dialuric acid and hydrogen peroxide.
Password Recovery Using an Evidence Collection Tool and Countermeasures (2007)

In this paper we propose a methodology used to analyse collected pagefiles belonging to public computers using a pagefile collection tool (PCT), which is suitable to be used in a live forensics context. After that, we investigated how to gather sensitive information such as passwords and usernames, which we found in half of the analysed pagefiles. Undoubtedly, this fact can be used by a forensics practitioner to solve the investigation faster, by using such information in order to acquire useful information about a crime. However, if such forensic pagefile collection tool was used as a hacking tool, it could cause leakage of privacy information. To be more precise, it allows easy gathering of critical information such as passwords and credit card numbers. Accordingly, in order to solve this problem, we have proposed a programming methodology to prevent the "swap-out" of sensitive information from main memory to pagefile. Finally, we also proposed a system model to perform the encryption of pagefile memory in order to improve the security of a computer system.
Effects of Entecavir on Hepatitis B Virus Covalently Closed Circular DNA in Hepatitis B e Antigen-Positive Patients with Hepatitis B (2015)

The aim of this study was to assess the effect of 48-week entecavir therapy on serum and intrahepatic hepatitis B virus, covalently closed circular DNA (HBV cccDNA) levels in hepatitis B e antigen (HBeAg)-positive patients. A total of 120 patients with HBeAg-positive chronic hepatitis were treated with entecavir for 48 weeks. Serum HBV markers, total HBV DNA, and HBV cccDNA levels were measured at baseline and week 48. Biopsies from 20 patients were available for both intrahepatic total HBV DNA and cccDNA testing at these timepoints. HBV cccDNA levels were decreased from a median level of 5.1×106 copies/mL at baseline to a median level of 2.4×103 copies/mL at week 48. Reduction magnitudes of HBV cccDNA in patients with normalized alanine aminotransferase levels and those undergoing HBeAg seroconversion were significantly greater than those in alanine aminotransferase-abnormal and HBeAg positive patients. Intrahepatic HBV cccDNA was decreased significantly after 48 weeks of treatment, but could not be eradicated. In conclusion, treatment of HBeAg-positive hepatitis B patients with entecavir for 48 weeks decreased serum and intrahepatic HBV cccDNA significantly, and the magnitude of HBV cccDNA reduction was related to total HBV DNA decrease, alanine aminotransferase normalization, and HBeAg seroconversion.
Common intermediate design language (1992)

The common intermediate design language (CIDL) is a high-level executable system design language intended for the evolutionary prototyping of large distributed software systems. CIDL was designed to be the target language for code synthesis from high-level system descriptions and the source language for translation into Ada. The resulting design is a typed language with higher-order functions, polymorphism, and concurrency constructs. The language uses types as a representation of formal specifications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pricing schemes in cloud computing:a review (2017)

Cloud is a group of hardware, network, interface and storage that enable the delivery of computing as a service. Cloud services consist, delivery of infrastructure, software and storage over the network based on user demand. NIST defines cloud computing as follows: "cloud computing is a model for enabling convenient, on-demand network access to a shared pool of configurable computing resources (e.g. Networks, servers, storage, applications and services) that can rapidly provision and released with minimal management effort or service provider interaction"[1]. Cloud services setup multi-tenancy. The cloud services like social networking (Facebook or Twitter) and collaboration tools (audio, video conferencing tools and webinar, etc.) are changing the method of people in accessing of business, providing and understanding information. The service provider in cloud model still works on the infrastructure in its own facilities. Irrespective of this, we are unaware about where computing resources, application or even data exist. Based on scale the service provider designs their infrastructure. The cloud provider provides the services to the customer based on demands.
Variations of blood flow at optic nerve head induced by sinusoidal flicker stimulation in cats. (1995)

1. The present investigation explored, in thirty-four anaesthetized cats, the blood flow changes at the optic nerve head elicited by sinusoidally modulated photic stimuli. 2. The stimuli were achromatic, diffuse and had 30 deg diameter field size; the stimulus frequency was varied from 0 to 100 Hz, modulation depth from 0 to 100% and mean retinal illuminance up to 50,000 trolands (td); the blood flow was measured with a near-infrared (810 nm) laser Doppler flowmeter. 3. At various frequencies, modulation depths and mean retinal illuminance, sinusoidal flicker stimulation always caused an increase in blood flow at the optic nerve head relative to steady stimulation. 4. The frequency response and temporal contrast sensitivity function of the blood flow changes had a bandpass shape; the high-frequency slope of the frequency response was 3 decades (dec) per decade and that of the temporal contrast sensitivity function was 1.7 dec per dec, close to the slope for cat 'on' ganglion cells (2.6 dec per dec). 5. In most cats, the magnitude of the increase in blood flow was a sigmoidal function of modulation depth; in the remainder, the relationship was close to linear. 6. The threshold of blood flow changes varied with respect to mean retinal illuminance similar to Ferry-Porter's law and the photopic linear slope was 50 Hz dec-1. 7. In comparison with reported psychophysical and electrophysiological responses elicited by similar stimulations, the results of the present study resemble more those obtained from ganglion cells than those from electroretinograms, visual-evoked potentials and psychophysics. It is suggested that the blood flow changes at the optic nerve head are induced by the activity of ganglion cells.
Measuring knowledge assets – implications of the knowledge economy for performance measurement (2004)

The business world has enthusiastically adopted the idea that knowledge has become the most strategic of corporate assets, the principal basis for competitive advantage. This enthusiasm has not, however, been matched by an understanding of how to operationalize knowledge. It seems we argue that knowledge is important largely because it is a different kind of asset. While this is perplexing and suggests that it is important to understand the strategic significance of the different kinds of organizational knowledge, it also raises operational issues for managers. How are they to identify knowledge assets, and measure them? We offer tentative proposals for a new approach to assets evaluation.
Helper Activity of Natural Killer Cells During the Dendritic Cell-mediated Induction of Melanoma-specific Cytotoxic T Cells (2011)

Natural killer (NK) cells have been shown to mediate important immunoregulatory "helper" functions in addition to their cytolytic activity. In particular, NK cells are capable of preventing maturation-related dendritic cell (DC) "exhaustion," inducing the development of "type-1 polarized" mature DCs (DC1) with an enhanced ability to produce interleukin (IL)-12p70, a factor essential for type-1 immunity and effective anticancer responses. Here we show that the NK cell-mediated type-1 polarization of DCs can be applied in the context of patients with advanced cancer to enhance the efficacy of DCs in inducing tumor-specific cytotoxic T lymphocytes. NK cells isolated from patients with late-stage (stage III and IV) melanoma responded with high interferon-γ production and the induction of type-1-polarized DCs on exposure to defined combinations of stimulatory agents, including interferon-α and IL-18. The resulting DCs showed strongly-enhanced IL-12p70 production on subsequent T-cell interaction compared with immature DCs (average of 19-fold enhancement) and nonpolarized IL-1β/TNF-α/IL-6/PGE(2)-matured "standard" DCs (average of 215-fold enhancement). Additional inclusion of polyinosinic: polycytidylic acid during NK-DC cocultures optimized the expression of CD80, CD86, CD40, and HLA-DR on the resulting (NK)DC1, increased their CCR7-mediated migratory responsiveness to the lymph node-associated chemokine CCL21, and further enhanced their IL-12-producing capacity. When compared in vitro with immature DCs and nonpolarized standard DCs, (NK)DC1 were superior in inducing functional melanoma-specific cytotoxic T lymphocytes capable of recognizing multiple melanoma-associated antigens and killing melanoma cells. These results indicate that the helper function of NK cells can be used in clinical settings to improve the effectiveness of DC-based cancer vaccines.
Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs (2015)

Colorectal cancers (CRCs) account for nearly 10% of all cancer deaths in industrialized countries. Recent evidence points to a central role for the nuclear receptor liver receptor homolog-1 (LRH-1) in intestinal tumorigenesis. Interaction of LRH-1 with the Wnt/β-catenin pathway, highly active in a critical subpopulation of CRC cells, underscores the importance of elucidating LRH-1's role in this disease. Reduction of LRH-1 diminishes tumor burden in murine models of CRC; however, it is not known whether LRH-1 is required for tumorigenesis, for proliferation, or for both. In this work, we address this question through shRNA-mediated silencing of LRH-1 in established CRC cell lines. LRH-1 mRNA knockdown results in significantly impaired proliferation in a cell line highly expressing the receptor and more modest impairment in a cell line with moderate LRH-1 expression. Cell-cycle analysis shows prolongation of G0/G1 with LRH-1 silencing, consistent with LRH-1 cell-cycle influences in other tissues. Cluster analysis of microarray gene expression demonstrates significant genome wide alterations with major effects in cell-cycle regulation, signal transduction, bile acid and cholesterol metabolism, and control of apoptosis. This study demonstrates a critical proproliferative role for LRH-1 in established colon cancer cell lines. LRH-1 exerts its effects via multiple signaling networks. Our results suggest that selected CRC patients could benefit from LRH-1 inhibitors.
Precision Time and Frequency Transfer Utilizing SONET OC-3 (1996)

An innovative method of distributing precise time and reference frequency to users located several kilometers from a frequency standard and master clock has been developed.
Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis (2010)

In erythroid cells, ferrous iron is imported into the mitochondrion by mitoferrin-1 (Mfrn1). Previously, we showed that Mfrn1 interacts with Abcb10 to enhance mitochondrial iron importation. Herein we have derived stable Friend mouse erythroleukemia (MEL) cell clones expressing either Mfrn1-FLAG or Abcb10-FLAG and by affinity purification and mass spectrometry have identified ferrochelatase (Fech) as an interacting protein for both Mfrn1 and Abcb10. Fech is the terminal heme synthesis enzyme to catalyze the insertion of the imported iron into protoporphyrin IX to produce heme. The Mfrn1-Fech and Abcb10-Fech interactions were confirmed by immunoprecipitation/Western blot analysis with endogenous proteins in MEL cells and heterologous proteins expressed in HEK293 cells. Moreover, Fech protein is induced in parallel with Mfrn1 and Abcb10 during MEL cell erythroid differentiation. Our findings imply that Fech forms an oligomeric complex with Mfrn1 and Abcb10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis.
Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase (2015)

Previously, we reported that a novel subpopulation of young mesenchymal stem cells (YMSCs) existed in old bone marrow, which possessed high antiaging properties as well as excellent efficacy for cardiac repair. MicroRNAs (miRNAs) have emerged as key regulators in post-transcriptional gene expression programs, and however, it is unknown whether miRNAs directly control stem cell senescence. Here we present the first evidence that miR-195 overexpressed in old MSCs (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR-195 can reverse stem cell aging. MiRNAs profiling analysis in YMSCs and OMSCs by microarray showed that miR-140, miR-146a/b, and miR-195 were significantly upregulated in OMSCs, which led us to hypothesize that these are age-induced miRNAs involved in stem cell senescence. Of these miRNAs, we found miR-195 directly targeted 3'-untranslated region of Tert gene by computational target prediction analysis and luciferase assay, and knockdown of miR-195 significantly increased Tert expression in OMSCs. Strikingly, miR-195 inhibition significantly induced telomere relengthening in OMSCs along with reduced expression of senescence-associated β-galactosidase. Moreover, silencing miR-195 in OMSCs by transfection of miR-195 inhibitor significantly restored antiaging factors expression including Tert and Sirt1 as well as phosphorylation of Akt and FOXO1. Notably, abrogation of miR-195 markedly restored proliferative abilities in OMSCs. Transplantation of OMSCs with knocked out miR-195 reduced infarction size and improved LV function. In conclusion, rejuvenation of aged stem cells by miR-195 inhibition would be a promising autologous therapeutic strategy for cardiac repair in the elderly patients.
Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19 patients (2020)

The pandemic Coronavirus-disease 19 (COVID-19) is characterized by a heterogeneous clinical course. While most patients experience only mild symptoms, a relevant proportion develop severe disease progression with increasing hypoxia up to acute respiratory distress syndrome. The substantial number of patients with severe disease have strained intensive care capacities to an unprecedented level. Owing to the highly variable course and lack of reliable predictors for deterioration, we aimed to identify variables that allow the prediction of patients with a high risk of respiratory failure and need of mechanical ventilation Patients with PCR proven symptomatic COVID-19 infection hospitalized at our institution from 29th February to 27th March 2020 (n=40) were analyzed for baseline clinical and laboratory findings. Patients requiring mechanical ventilation 13/40 (32.5%) did not differ in age, comorbidities, radiological findings, respiratory rate or qSofa score. However, elevated interleukin-6 (IL-6) was strongly associated with the need for mechanical ventilation (p=1.2.10 -5 ). In addition, the maximal IL-6 level (cutoff 80 pg/ml) for each patient during disease predicted respiratory failure with high accuracy (p=1.7.10 -8 , AUC=0.98). The risk of respiratory failure for patients with IL-6 levels of >; 80 pg/ml was 22 times higher compared to patients with lower IL-6 levels. In the current situation with overwhelmed intensive care units and overcrowded emergency rooms, correct triage of patients in need of intensive care is crucial. Our study shows that IL-6 is an effective marker that might be able to predict upcoming respiratory failure with high accuracy and help physicians correctly allocate patients at an early stage.
Blood Flow Dynamics in Cerebral Aneurysm - A CFD Simulation (2015)

In the present study, the dynamics of blood flow in saccular cerebral aneurysms is investigated. The aneurysm is considered to be located at an arterial bend in human vascular system. The flow field is analyzed computationally by three-dimensional Navier-Stokes equation for laminar flow of incompressible Newtonian fluid. Circular and elliptical necks of different sizes are studied. The vascular wall is considered rigid for simplicity. Hemodynamic parameters such as velocity, pressure, vortices, wall shear stress and so on are considered for characterization of flow field. Results showed that the vortex location, inflow area in the neck and so on are varied significantly with the geometrical parameter of the aneurysm.
GPS-Based Time & Phase Synchronization Processing for Distributed SAR (2009)

Distributed synthetic aperture radar (DiSAR), including bi- and multistatic SAR, operates with distinct transmitting and receiving antennas that are mounted on separate platforms. Spatial separation has several operational advantages, such as reduced vulnerability in military applications and increased radar cross section (RCS); which may increase the capability, reliability, and flexibility of future aerospace remote sensing missions. However, in this configuration, there is no cancellation of reference oscillator phase noise as in monostatic cases. There are additional technical problems associated with temporal synchronization of the transmit and receive systems. Therefore, highly accurate time and phase synchronization must be provided. Little work on these challenges has been reported. This paper presents a Global Positioning System (GPS)-based technique for achieving successful time and phase synchronization for DiSAR. This technique offers high-frequency stability. More importantly, residual time synchronization errors may be compensated for with a high-precision range alignment method, and residual phase synchronization errors may be compensated for with a subaperture autofocus algorithm.
Low-loss microwave cavity using layered-dielectric materials (1994)

Loss measurements have been carried out on a cylindrical pillbox cavity whose metallic flat end walls have been replaced by an ordered sequence of high purity sapphire and air dielectric layers. The loss of the TE01 mode at 18.99 GHz was substantially lowered. An improvement in cavity Q for this mode from 8.30×103 to 531×103 was observed. These experimental results closely reproduce two independent theoretical simulations. All measurements were taken at 30 °C.
10 Gbit/s 2-PSK transmission and homodyne coherent detection using commercial optical components (2003)

Abstract: We present a demonstration of coherent homodyne transmission using 2-PSK at 10Gbit/s, with commercial optical components, which leads to new compact integrated receivers and new transmission formats, thus opening new possibilities for future optical systems.