gebhart/patrepeval huggingface dataset:
Komplexer ist einfacher (2012)

Abstract Die sechste Welle des Artensterbens auf der Erde hat gerade erst begonnen. Doch die Forschung richtet ihren Blick schon weiter: Womit haben natürliche Ökosysteme künftig zu kämpfen? Analysen ausgedehnter Netzwerke führen zu überraschend klaren Vorhersagen.
Improved Model for Increased Surface Recombination Current in Irradiated Bipolar Junction Transistors (2015)

Current gain degradation in irradiated bipolar junction transistors is primarily due to excess base current caused by enhanced carrier recombination in the emitter-base space-charge region (SCR). Radiation-induced traps at the interface between silicon and the bipolar base oxide facilitate the recombination process primarily above the sensitive emitter-base junction. This leads to an increase in surface recombination current in the SCR, which is a non-ideal component of the BJT's base current characteristic under active bias conditions. In this paper, we derive a precise analytical model for surface recombination current that captures bias dependencies typically omitted from traditional models. This improved model is validated by comparisons to these traditional approaches.
Current-sourcing push-pull parallel-resonance inverter (CS-PPRI): theory and application as a fluorescent lamp driver (2002)

A novel topology, current-sourcing push-pull parallel-resonance inverter (CS-PPRI), is investigated theoretically and experimentally. The proposed power stage is built around a current fed push-pull inverter. The main features of the proposed inverter are a load-independent output current and zero voltage switching (ZVS). It is suggested that the proposed CS-PPRI is a viable alternative for realizing electronic ballasts for low and high intensity discharge lamps.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H) (2011)

Cholesterol ester lipase (LIPA; EC 3.1.1.13) and cholesterol 25-hydroxylase (CH25H; EC 1.14.99.48) play essential role in cholesterol metabolism in the body by hydrolysing cholesteryl esters and triglycerides within lysosomes (LIPA) and catalysing the formation of 25-hydroxycholesterol from cholesterol (CH25H) which acts to repress cholesterol biosynthesis. Bioinformatic methods were used to predict the amino acid sequences, structures and genomic features of several vertebrate LIPA and CH25H genes and proteins, and to examine the phylogeny of vertebrate LIPA. Amino acid sequence alignments and predicted subunit structures enabled the identification of key sequences previously reported for human LIPA and CH25H and transmembrane structures for vertebrate CH25H sequences. Vertebrate LIPA and CH25H genes were located in tandem on all vertebrate genomes examined and showed several predicted transcription factor binding sites and CpG islands located within the 5' regions of the human genes. Vertebrate LIPA genes contained nine coding exons, while all vertebrate CH25H genes were without introns. Phylogenetic analysis demonstrated the distinct nature of the vertebrate LIPA gene and protein family in comparison with other vertebrate acid lipases and has apparently evolved from an ancestral LIPA gene which predated the appearance of vertebrates. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13205-011-0013-9) contains supplementary material, which is available to authorized users.
Copper complexation by siderophores from filamentous blue‐green algae1 (1980)

From our experimental evidence that iron limitation greatly increases the extracellular concentration of strong copper‐complexing agents in cultures of Anabaena flos‐aquae and Anabaena cylindrica , and that the iron‐algal exudate complex is much more stable than the copper complex, we conclude that strong copper‐complexing agents released by filamentous blue‐green algae are siderophores. Further experiments demonstrate that siderophore excretion is not a mechanism by which blue‐green algae overcome the toxic effects of micromolar copper additions. From estimates of concentrations of iron, copper, and siderophores in iron‐limited blue‐green algal blooms, it is predicted that the copper‐siderophore complex is the major copper species. The copper‐siderophore complex is probably not toxic and its presence in freshwaters may be advantageous to cyanophyte populations.
A novel subgroup of exogenous avian leukosis virus in chickens (1991)

An avian leukosis virus with a wide host range belonging to a new subgroup for chickens was isolated from meat-type chicken lines. The virus, of which HPRS-103 strain is the prototype, was of low oncogenicity in chickens but appeared to behave like an exogenous leukosis virus. Neutralizing antibodies to the virus were found in three of five meat-type chicken lines, but not in seven layer lines. The virus and its Rous sarcoma virus pseudotype did not replicate in, or transform, mammalian cells.
Comparison of statistical algorithms for daily syndromic surveillance aberration detection (2019)

Supplementary data are available at Bioinformatics online.
Temporal Pattern Recognition in Video Clips Detection (2009)

Temporal representation and reasoning plays an important role in Data Mining and Knowledge Discovery, particularly, in mining and recognizing patterns with rich temporal information. Based on a formal characterization of time-series and state-sequences, this paper presents the computational technique and algorithm for matching state-based temporal patterns. As a case study of real-life applications, zone-defense pattern recognition in basketball games is specially examined as an illustrating example. Experimental results demonstrate that it provides a formal and comprehensive temporal ontology for research and applications in video events detection.
Rapid, Transient Phosphatidylserine Externalization Induced in Host Cells by Infection with<i>Chlamydia</i>spp (2001)

Chlamydia organisms are obligate intracellular bacterial pathogens responsible for a range of human diseases. Persistent infection or reinfection with Chlamydia trachomatis leads to scarring of ocular or genital tissues, and Chlamydia pneumoniae infection is associated with the development of atherosclerosis. We demonstrate that C. trachomatis and C. pneumoniae infection in vitro elicits the externalization of the lipid phosphatidylserine on the surface of human epithelial, endothelial, granulocytic, and monocytic cells. Phosphatidylserine externalization is associated with cellular development, differentiation, and death. Infection-induced phosphatidylserine externalization was immediate, transient, calcium dependent, and infectious dose dependent and was unaffected by a broad-spectrum caspase inhibitor. Chlamydia-infected cells accelerated plasma clotting and increased the macrophage phagocytosis of infected cells that was phosphatidylserine dependent. The rapid externalization of phosphatidylserine by infected cells may be an important factor in the pathogenesis of chlamydial infections.
Polymers in Optical Recording (1988)

Optical information storage, which has been a dream since the discovery of the laser, is now becoming a commercial reality. Read-only consumer products (video and digital audio disks) have provided a solid technological base for the development and introduction of the more sophisticated write-once and erasable recording systems. This chapter will review the current status of polymeric materials as substrates, protective layers, and active recording media in laser recording.
Trends in healthcare computing. (1992)

Almost 550 healthcare professionals were polled for their perceptions of information technology--as it relates to their facilities--at the 1992 Annual Healthcare Information and Management Systems Society Conference. Conducted by J.C. Pollock Associates, Princeton, N.J., and commissioned by HIMSS and Hewlett-Packard Co., the survey responses reflect general optimism about information system procurement and use in America's hospitals. Actual responses to multiple-choice, technology-related survey questions are charted on this and following pages.
Nuclear localization of the Escherichia coli cytolethal distending toxin CdtB subunit (2004)

Cytolethal distending toxin (CDT) is a heterotrimeric protein toxin produced by several bacterial pathogens. Cells exposed to CDT die from either activation of the mitotic checkpoint cascade or apoptosis. Introduction of the purified CdtB subunit, a homologue of mammalian type I DNase, into cells mimics the action of the CDT holotoxin. Mutant CdtBs lacking DNase activity are devoid of biological activity. Chromosomal DNA appears to be the CDT target; thus, nuclear translocation of CdtB must precede cytolethal activity. Examination of the CdtB sequence indicates the presence of putative candidate bipartite nuclear localization signals (NLS). Here, we examine the functionality of the two potential NLS sequences found in the Escherichia coli CdtB-II. Nuclear translocation of EcCdtB-II was examined by monitoring the localization of an EcCdtB-II-EGFP fusion in Cos-7 cells. Our results indicated that EGFP-EcCdtB-II localized to the nucleus. The candidate EcCdtB-II-II NLS sequences were modified by site-directed mutagenesis such that tandem arginine residues were changed to threonine and serine respectively. Mutation of both putative NLS sequences had no effect on EcCdtB-II-associated DNase activity; however, cell cycle arrest and nuclear localization were significantly impaired in cells that received CDT reconstituted from the EcCdtB-II-DeltaNLS mutants. When HeLa cells were electroporated with the EcCdtB-II-DeltaNLS1 and the EcCdtB-II-NLS double mutants, toxicity was not observed, whereas the activity of EcCdtB-II-DeltaNLS2 was similar to that of wild-type EcCdtB-II. These data indicate that the putative NLS sequences are important for CDT-mediated action arrest and that they are likely to function in the nuclear translocation of EcCdtB-II.
Gadolinium Decreases Stretch-Induced Vulnerability to Atrial Fibrillation (2000)

Acute atrial stretch significantly enhances the vulnerability to AF. Gd(3+) reduces the stretch-induced vulnerability to AF in a dose-dependent manner. Block of SAC might represent a novel antiarrhythmic approach to AF under conditions of elevated atrial pressure or volume.
The α<sub>1</sub>-Fetoprotein Locus Is Activated by a Nuclear Receptor of the <i>Drosophila</i> FTZ-F1 Family (1996)

The alpha1-fetoprotein (AFP) gene is located between the albumin and alpha-albumin genes and is activated by transcription factor FTF (fetoprotein transcription factor), presumed to transduce early developmental signals to the albumin gene cluster. We have identified FTF as an orphan nuclear receptor of the Drosophila FTZ-F1 family. FTF recognizes the DNA sequence 5'-TCAAGGTCA-3', the canonical recognition motif for FTZ-F1 receptors. cDNA sequence homologies indicate that rat FTF is the ortholog of mouse LRH-1 and Xenopus xFF1rA. Rodent FTF is encoded by a single-copy gene, related to the gene encoding steroidogenic factor 1 (SF-1). The 5.2-kb FTF transcript is translated from several in-frame initiator codons into FTF isoforms (54 to 64 kDa) which appear to bind DNA as monomers, with no need for a specific ligand, similar KdS (approximately equal 3 x 10(-10) M), and similar transcriptional effects. FTF activates the AFP promoter without the use of an amino-terminal activation domain; carboxy-terminus-truncated FTF exerts strong dominant negative effects. In the AFP promoter, FTF recruits an accessory trans-activator which imparts glucocorticoid reactivity upon the AFP gene. FTF binding sites are found in the promoters of other liver-expressed genes, some encoding liver transcription factors; FTF, liver alpha1-antitrypsin promoter factor LFB2, and HNF-3beta promoter factor UF2-H3beta are probably the same factor. FTF is also abundantly expressed in the pancreas and may exert differentiation functions in endodermal sublineages, similar to SF-1 in steroidogenic tissues. HepG2 hepatoma cells seem to express a mutated form of FTF.
Kintinuous: Spatially Extended KinectFusion (2012)

Abstract—In this paper we present an extension to the KinectFusion algorithm that permits dense mesh-based mapping of extended scale environments in real-time. This is achieved through (i) altering the original algorithm such that the region of space being mapped by the KinectFusion algorithm can vary dynamically, (ii) extracting a dense point cloud from the regions that leave the KinectFusionvolume due tothisvariation, and,(iii) incrementally adding the resulting points to a triangular mesh representation of the environment. The system is implemented as a set of hierarchical multi-threaded components which are capable of operating in real-time. The architecture facilitates the creation and integration of new modules with minimal impact on the performance on the dense volume tracking and surface reconstruction modules. We provide experimental results demonstrating the system’s ability to map areas considerably beyond the scale of the original KinectFusionalgorithm including a two story apartment and an extended sequence taken from a car at night. In order to overcome failure of the iterative closest point (ICP)based odometry in areas of low geometric features we have evaluated the Fast Odometry from Vision (FOVIS) system as an alternative. We provide a comparison between the two approaches where we show a trade off between the reduced drift of the visual odometry approach and the higher local mesh quality of the ICP-based approach. Finally we present ongoing work on incorporating full simultaneous localisation and mapping (SLAM) pose-graph optimisation. I.
Large number of phosphotransferase genes in the Clostridium beijerinckii NCIMB 8052 genome and the study on their evolution (2010)

This work may explain the experimental result that Clostridium beijerinckii NCIMB 8052 can better utilize fructose as substrate, thus could lead to a better understanding of the ABE-producing mechanism in Clostridium beijerinckii and other microbial species. It may help to illustrate a higher butanol-productivity future.
Condensation Reactions of a Nitro Group. II.<sup>1</sup> Preparation of Phenanthridine-5-oxides and Benzo(c)cinnoline-1-oxide<sup>2</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCondensation Reactions of a Nitro Group. II.1 Preparation of Phenanthridine-5-oxides and Benzo(c)cinnoline-1-oxide2CHESTER W. MUTH, NAZEM ABRAHAM, MYRON L. LINFIELD, ROBERT B. WOTRING, and EDWARD A. PACOFSKYCite this: J. Org. Chem. 1960, 25, 5, 736–740Publication Date (Print):May 1, 1960Publication History Published online1 May 2002Published inissue 1 May 1960https://pubs.acs.org/doi/10.1021/jo01075a016https://doi.org/10.1021/jo01075a016research-articleACS PublicationsRequest reuse permissionsArticle Views395Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dynamic temperature measurement in microfluidic devices using thermochromic liquid crystals (2008)

Thermochromic liquid crystals (TLCs) are used to explore the temperature transients during thermal cycling for microchip-based polymerase chain reaction (PCR). By analyzing the reflected spectra of the TLCs over time, temperature vs. time trajectories were extracted and overshoots/undershoots were estimated. To our knowledge, this is the first report of TLC-based dynamic temperature measurements in a microfluidic device for all PCR temperature stages.
Vaccinations with tumor cells genetically engineered to produce different cytokines: effectivity not superior to a classical adjuvant. (1993)

The potential of tumor cells (J558L) engineered to produce one of 5 different cytokines (interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or gamma-interferon) to give rise to systemic immunity protective against a contralateral challenge with the parental cells was analyzed. The rejection of all cytokine-producing cells appeared to induce some systemic response capable of mediating the rejection of low numbers of subsequently contralaterally injected cells, but the effect was much less obvious with higher cell numbers. The injection of any possible combination of two of the cytokine producers did not reveal any synergistic effects. The cytokine gene-transfected tumor cells were not superior to the parental cells admixed with the adjuvant Corynebacterium parvum with respect to their potential as immunogens to induce immunity.
Effects of herbal compound 861 on human hepatic stellate cell proliferation and activation (2004)

Cpd 861 can significantly inhibit LX-2 cell proliferation in a dose-dependent manner, and reduce the expression levels of alpha-SMA mRNA in LX-2 cells. Since hepatic cell proliferation and high level of alpha-SMA are associated with liver fibrosis, the results suggest that Cpd 861 may be useful in the treatment of this disease.
Software engineering research versus software development (2005)

Engineering research differs greatly, both in its aims and in its methods, from traditional "scientific" research. While Sciences deal with the study of existing objects and phenomena, be it physically, metaphysically or conceptually, Engineering is based on how to do things, how to create new objects. For this reason, "scientific" research methods are not always directly applicable to research problems of an engineering nature.In the present article, we concentrate on the problems and research methods of a specific branch of engineering: Software Engineering, discussing, on the one hand, the nature of the method in this field while and, on the other, the similarity of the methods of research in Software Engineering and those of software development.
Anosmia—A Clinical Review (2017)

Anosmia and hyposmia, the inability or decreased ability to smell, is estimated to afflict 3-20% of the population. Risk of olfactory dysfunction increases with old age and may also result from chronic sinonasal diseases, severe head trauma, and upper respiratory infections, or neurodegenerative diseases. These disorders impair the ability to sense warning odors in foods and the environment, as well as hinder the quality of life related to social interactions, eating, and feelings of well-being. This article reports and extends on a clinical update commencing at the 2016 Association for Chemoreception Sciences annual meeting. Included were reports from: a patient perspective on losing the sense of smell with information on Fifth Sense, a nonprofit advocacy organization for patients with olfactory disorders; an otolaryngologist's review of clinical evaluation, diagnosis, and management/treatment of anosmia; and researchers' review of recent advances in potential anosmia treatments from fundamental science, in animal, cellular, or genetic models. As limited evidence-based treatments exist for anosmia, dissemination of information on anosmia-related health risks is needed. This could include feasible and useful screening measures for olfactory dysfunction, appropriate clinical evaluation, and patient counseling to avoid harm as well as manage health and quality of life with anosmia.
Systematic sequencing of the Bacillus subtilis genome: progress report of the Japanese group (1995)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Highly luminescing multi-shell semiconductor nanocrystals InP/ZnSe/ZnS (2012)

We design, synthesize, and characterize multi-shell quantum dot structure of an indium phosphide core surrounded by zinc chalcogenide shells. A simple mathematical model describing the wave function of electronhole pairs enabled us to design ZnSe and ZnS shells to confine the carriers inside the core region effectively. The result indicates that the designed multi-shell quantum dots show improved optical properties that are more robust against chemical and photo-environmental changes.
How Trending Status and Online Ratings Affect Prices of Homogeneous Products (2016)

The online retailing environment has grown more complex with the myriad information items available for customers to peruse. Two such information items include the trending lists of currently popular products, and online customer reviews and ratings of products. A trending product is one that relatively large groups of people are currently browsing, purchasing, or discussing. In this paper, we analyze the pricing implications of both types of information items. Our main goal is to test whether, acting as signals of desirability and popularity, a trending status or high ratings and reviews can lead to price cuts on homogeneous products. We provide empirical support for a model that demonstrates these relationships using data on books from twenty-four categories of Amazon.com. An important theoretical contribution of our model is that even in the absence of strategic considerations or demand dependencies, our model suggests lower prices for trending and positively reviewed products. Our work shows that pricing systems using popularity and average customer ratings as inputs can help achieve increased profitability.
Low-complexity Seysen's algorithm based lattice reduction-aided MIMO detection for hardware implementations (2010)

Lattice reduction-aided linear detectors for MIMO systems are a promising receiver structure for low-complexity implementations. In this paper we present a lattice reduction-aided MIMO data detection architecture based on Seysen's algorithm, where the algorithm is carried out exclusively on the Gram matrix of the channel and its inverse. Furthermore, we describe and evaluate several modification of Seysen's algorithm tailored to reduce the total complexity with respect to hardware implementation. By means of complexity-performance trade-offs we demonstrate the potential benefit of the various algorithmic modifications. First, novel schemes to identify the update steps in each iteration of Seysen's algorithm are presented. Second, we show that further complexity reduction of Seysen's algorithm can be obtained by severely constraining the update coefficients. Eventually, methods are devised that terminate Seysen's algorithm prematurely and thus result in a reduction of the average complexity.