gebhart/patrepeval huggingface dataset:
Estimation of Cardiac Respiratory-Motion by Semi-Automatic Segmentation and Registration of Non-Contrast-Enhanced 4D-CT Cardiac Datasets (2009)

The goal of this work is to investigate, for a large set of patients, the motion of the heart with respiration during free-breathing supine medical imaging. For this purpose we analyzed the motion of the heart in 32 non-contrast enhanced respiratory-gated 4D-CT datasets acquired during quiet unconstrained breathing. The respiratory-gated CT images covered the cardiac region and were acquired at each of 10 stages of the respiratory cycle, with the first stage being end-inspiration. We devised a 3-D semi-automated segmentation algorithm that segments the heart in the 4D-CT datasets acquired without contrast enhancement for use in estimating respiratory motion of the heart. Our semi-automated segmentation results were compared against interactive hand segmentations of the coronal slices by a cardiologist and a radiologist. The pairwise difference in segmentation among the algorithm and the physicians was on the average 11% and 10% of the total average segmented volume across the patient, with a couple of patients as outliers above the 95% agreement limit. The mean difference among the two physicians was 8% with an outlier above the 95% agreement limit. The 3-D segmentation was an order of magnitude faster than the Physicians' manual segmentation and represents significant reduction of Physicians' time. The segmented first stages of respiration were used in 12 degree-of-freedom (DOF) affine registration to estimate the motion at each subsequent stage of respiration. The registration results from the 32 patients indicate that the translation in the superior-inferior direction was the largest component motion, with a maximum of 10.7 mm, mean of 6.4 mm, and standard deviation of 2.2 mm. Translation in the anterior-posterior direction was the next largest component of motion, with a maximum of 4.0 mm, mean of 1.7 mm, and standard deviation of 1.0 mm. Rotation about the right-left axis was on average the largest component of rotation observed, with a maximum of 4.6 degrees, mean of 1.6 degrees, and standard deviation of 2.1 degrees. The other rotation and shear parameters were all close to zero on average indicting the motion could be reasonably well approximated by rigid-body motion. However, the product of the three scale factors averaged about 0.97 indicating the possibility of a small decrease in heart volume with expiration. The motion results were similar whether we used the Physician's segmentation or the 3-D algorithm.
The Structure of Macrocyclic Glycine Peptides (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of Macrocyclic Glycine PeptidesC. H. Bamford and F. J. WeymouthCite this: J. Am. Chem. Soc. 1955, 77, 23, 6368–6369Publication Date (Print):December 1, 1955Publication History Published online1 May 2002Published inissue 1 December 1955https://pubs.acs.org/doi/10.1021/ja01628a087https://doi.org/10.1021/ja01628a087research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Breakdown and Reestablishment of Blood-Aqueous Barrier With Implant Surgery (1982)

Preoperative and serial postoperative anterior chamber fluorophotometry was performed after oral administration of fluorescein sodium in patients undergoing extracapsular cataract extraction combined with intraocular lens implantation. In placebo-treated eyes, the blood-aqueous barrier was reestablished at three months after surgery. The administration of topical indomethacin before and after surgery markedly decreased aqueous fluorescein concentration, and the blood-aqueous barrier was reestablished within five weeks. Because all patients were given sub-Tenon's injection of steroids immediately after surgery and intensive topical steroid therapy postoperatively, the effect of topical indomethacin was additive to or synergistic with steroids. The addition of topical indomethacin caused a small but statistically significant increase in the postoperative intraocular pressure; this effect lasted nine weeks.
Sensors in Smart Homes for Independent Living of the Elderly (2018)

A rapidly ageing population requires support systems which would enable them to preserve dwellers' independence without compromising on their safety or their quality of life. Smart homes for the elderly have the potential to offer unobtrusive health and wellness monitoring. The aim is to provide a safe, independent living environment which can identify and predict problems by monitoring the activities of daily living (ADLs) of the inhabitants. For this, a system able to handle continuous streams of data is required. Such a system can extract the information by using appropriate classification and learning algorithms and thus allow the remote monitoring of health and wellbeing at a high level. The implementation requires: the use of appropriate sensing technologies, identification of ADLs, data pre-processing techniques and machine learning algorithms. This is challenging due to individual differences: such a system must be able to personalize individual needs. Our contribution was the design and implementation of a platform to smartly monitor health condition of elderly using sensor data from a smart home, through an interactive user interface which is user-friendly and multi-platform. This proof-of-concept used off-line data, with the view to extend to real-time data collection in the future, which could then be used to inform support providers remotely.
Remarkably low turn-on field emission in undoped, nitrogen-doped, and boron-doped graphene (2010)

Field emission studies have been carried out on undoped as well as N- and B-doped graphene samples prepared by arc-discharge method in a hydrogen atmosphere. These graphene samples exhibit very low turn-on fields. N-doped graphene shows the lowest turn-on field of 0.6 V/μm, corresponding to emission current density of 10 μA/cm2. These characteristics are superior to the other types of nanomaterials reported in the literature. Furthermore, emission currents are stable over the period of more than 3 h for the graphene samples. The observed emission behavior has been explained on the basis of nanometric features of graphene and resonance tunneling phenomenon.
The correlation between mechanical stress and magnetic properties of ultrathin films (1998)

The cantilever bending beam technique was applied to measure film stress, film magnetization and magneto-elastic coupling in nanometre Fe films grown epitaxially on W substrates. A simple optical deflection technique yielded sub-monolayer sensitivity for stress measurements and was used to determine magnetization and magnetostrictive properties of nanometre Fe films in situ. The combination of an electromagnet inside an ultra-high-vacuum chamber with a rotatable external magnet was employed to perform magneto-optical Kerr-effect measurements in the transversal, longitudinal and polar geometry in fields of up to 0.4 T. Examples for stress-driven structural changes in monolayer Fe films are discussed with respect to the unusual high coercivity found for sesquilayer Fe films and the re-orientation of the easy axis of magnetization in Stranski-Krastanov Fe films. The direct correlation between strain and magnetism was exploited to measure the magnetostrictive bending of the film-substrate composite. The magnitude and sign of the magneto-elastic coupling coefficient were found to depend on the film thickness, in contrast to the respective bulk values.
Measurement of the affinity of melittin for zwitterionic and anionic membranes using immobilized lipid biosensors (2001)

The binding of melittin to zwitterionic dimyristyphosphatidylcholine (DMPC) and anionic dimyristylphosphatidylglycerol (DMPG) was analysed using two different immobilized model membrane systems. The first system used surface plasmon resonance (SPR), which monitors the real-time binding of peptides to an immobilized hybrid bilayer. SPR experiments reflected a stronger binding of melittin for DMPG than for DMPC, while kinetic analysis suggested the existence of at least two distinct binding steps. The second lipid biosensor system involved an immobilized phospholipid monolayer covalently attached to a microporous silica surface. The binding of melittin to the immobilized monolayer was then monitored using dynamic elution chromatography with varied methanol concentrations to analyse the binding of melittin to DMPC and DMPG. The nonlinear binding behaviour observed for melittin with the phosphatidylcholine (PC) and phosphatidylglycerol (PG) monolayers compared with the linear retention plots and Gaussian peak shapes observed for the control molecule demonstrated that melittin undergoes significant conformational and orientational changes upon binding to the immobilized PC and PG ligands. The dependence of log k' on per cent methanol also demonstrated a bimodal interaction whereby hydrophobic forces predominated at higher temperatures and methanol concentrations, while other forces, presumably electrostatic in nature, also made a contribution to the affinity of the peptides for the lipid monolayer, particularly at lower temperatures. The complementary use of these two lipid biosensors thus allows the role of hydrophobic and electrostatic forces in peptide-membrane interactions to be studied.
Methods for engine supervision and control based on cylinder pressure information (1999)

The increasing demands for low emissions and low fuel consumption in modern combustion engines require improved methods for online diagnosis and best possible control of the combustion process. It is demonstrated that the cylinder pressure signal can successfully be used for this task. After introduction of some theoretical background, several application examples are presented: an online supervision of fuel injection, some results on feedforward emission control, and a concept for feedback control of spark timing. Experimental results obtained from stock car diesel and spark ignition engines are included to support the automation concepts.
Slow Light VCSEL Amplifier for High-resolution Beam Steering and High-power Operations (2016)

We demonstrate the high-resolution beam-steering and amplification of novel VCSEL amplifiers, exhibiting beam steering of over 25° and sharp beam divergence of 0.1°. The output power reaches at 29mW with a chip gain of 18dB.
Sensitive Detection of Helicobacter pylori in Gastric Aspirates by Polymerase Chain Reaction (1998)

The detection of Helicobacter pylori in gastric aspirate was examined by using the polymerase chain reaction (PCR) method for amplifying a specific fragment of the urease gene A. The ability of PCR to amplify H. pylori-specific DNA was analyzed by Southern hybridization with an internal oligonucleotide probe. Twenty-two H. pylori strains from clinical isolates and reference strains were studied, and all H. pylori strains yielded a 356-bp product that hybridized with the oligonucleotide probe, whereas no amplification was evident with 18 non-H. pylori strains. This could detect as little as 50 CFU of H. pylori in pure culture and 0.1 pg of purified chromosomal DNA. A total of 50 dyspeptic patients were examined for the presence of H. pylori by culture, the rapid urease test and histological examination of antral biopsy samples as well as by PCR in gastric juice aspirate samples. The gold standard for the presence of H. pylori was established by minimum concordance of two of three tests performed on biopsy specimens. With this gold standard, 34 of the 50 patients were considered to harbor H. pylori infection. PCR correctly identified 32 (94.1%) of these 34 infected patients. PCR had the best combination of sensitivity and specificity in assessing the correct diagnosis of H. pylori as compared with those of the rapid urease test and culture. Moreover, we established a fast and simple method for use by improvement of DNA extraction. PCR of the gastric aspirate was shown to be a sensitive and specific procedure which may be an attractive alternative to methods currently used for diagnosis of H. pylori infection.
High Temperature Tensile Deformation Behavior of New Heat Resistant Aluminum Alloy (2011)

This study attempted to investigate the high temperature tensile deformation behaviour of new Al-1%Mg-1.1%Si-0.8%CoNi heat resistant aluminium alloy. New aluminium alloy strengthened by Co-Ni based phase was manufactured by using powder ball milling and continuous casting, based on the alloy design & preliminary test. High temperature tensile tests were conducted at various temperatures from 25 °C to 450 °C. OM, SEM, EPMA, XRD, FIB and HR-TEM equipments were used to analyse microstructure, phases, and fracture surface. Microstructure of the new alloy mainly consisted of Al matrix and Co-Ni based phases (1∼8 μm). The Co-Ni based phase was analyzed and confirmed as (Ni, Co)3Al having incoherent interface with matrix. In high temperature tensile results, the new aluminium alloy didn’t show significant decrease (19.6%) of strength with increasing temperature (450 °C), suggesting totally different behaviour with conventional A319 alloy (87.0% decrease of T.S.). Fractography observation results of new alloy represented the ductile fracture mode with dimples. Voids were mainly initiated at Co-Ni based strengthening phases. It was apparently observed that the strengthening effect of the (Ni, Co)3Al could be still maintained at high temperature of 450 °C. The deformation mechanism of this alloy was also discussed.
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics (2001)

Methanogenesis, the anaerobic production of methane from CO2 or simple carbon compounds, requires seven organic coenzymes. This review describes pathways for the biosynthesis of methanofuran, 5,6,7,8-tetrahydromethanopterin, coenzyme F420, coenzyme M (2-mercaptoethanesulfonic acid) and coenzyme B (7-mercaptoheptanoyl-L-threonine phosphate). Spectroscopic evidence for the pathways is reviewed and recent efforts are described to identify and characterize the biosynthetic enzymes from methanogenic archaea. The literature from 1971 to September 2001 is reviewed, and 169 references are cited.
Interactive segmentation, tracking, and kinematic modeling of unknown 3D articulated objects (2013)

We present an interactive perceptual skill for segmenting, tracking, and modeling the kinematic structure of 3D articulated objects. This skill is a prerequisite for general manipulation in unstructured environments. Robot-environment interactions are used to move an unknown object, creating a perceptual signal that reveals the kinematic properties of the object. The resulting perceptual information can then inform and facilitate further manipulation. The algorithm is computationally efficient, handles partial occlusions, and depends on little object motion; it only requires sufficient texture for visual feature tracking. We conducted experiments with everyday objects on a robotic manipulation platform equipped with an RGB-D sensor. The results demonstrate the robustness of the proposed method to lighting conditions, object appearance, size, structure, and configuration.
Synthesis and Antispasmodic Activity Evaluation of Bis-(Papaverine) Analogues (2004)

A new series of N-substituted bis-(tetrahydropapaverine) ring systems have been synthesised in expectation of better antispasmodic activity in comparison with papaverine. The synthesis of the targeted heterocycles is described along with a discussion of their structure activity relationship. The general synthetic methods of bis-(tetrahydropapaverine) analogues involve tetrahydropapaverine, various piperazines, diisocyanates and diisothiocyanates as starting materials. Pharmacological evaluation involves the in vitro antispasmodic activity on a freshly removed guinea pig ileum using a force displacement transducer amplifier connected to a physiograph. Among the analogues synthesized in the present study, N,N'-bis-[2-carbamoyl-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolinyl]piperazine (22), was found to be the most potent muscle relaxant (IC(50): 0.31 microM).
Tissue damage thresholds during therapeutic electrical stimulation (2016)

It is apparent that emerging applications, especially with microelectrodes, will require clinical charge densities that exceed traditional damage thresholds. Experimental data show that stimulation at higher charge densities can be achieved without causing tissue damage, suggesting that safety parameters for microelectrodes might be distinct from those defined for macroelectrodes. However, these increased charge densities may need to be justified by bench, non-clinical or clinical testing to provide evidence of device safety.
2-D Edge Feature Extraction To Subpixel Accuracy Using The Generalized Energy Approach (2005)

Precision edgefeature extraction is a very important step in vision. Researchers mainly use step edges to model an edge at subpixel level. In this paper we describe a new technique for two dimensional edge feature extraction to subpixel accuracy using a general edge model. Using six basic edge types to model edges, the edge parameters at subpixel level are extracted byfitting a model to the image signal using least-squared errorfitting technique.
Chapter 1 - How Pop Culture Shapes - Full Chapter.pdf (2016)

Becoming a Girl: Pop Culture'sFirst Stage of Gender Training
Design of portable biometric authenticators - energy, performance, and security tradeoffs (2004)

Biometrics have become a popular means for access control and authentication. As the processing power of embedded systems has grown, efforts have been made to perform biometrics locally on constrained devices such as smart cards. This paper presents the design and consumer application of a portable fingerprint biometric authenticator with the form factor of a key dongle (as an alternative to biometric smart cards). A thorough investigation has been performed to determine the tradeoffs between security, performance, and energy and to determine the secure partitioning between dongle and server. Such a device could be used for applications such as automotive access control, secure credit card payments, and related authentication scenarios.
Towards a petawatt-class few-cycle infrared laser system via dual-chirped optical parametric amplification (2018)

Expansion of the wavelength range for an ultrafast laser is an important ingredient for extending its range of applications. Conventionally, optical parametric amplification (OPA) has been employed to expand the laser wavelength to the infrared (IR) region. However, the achievable pulse energy and peak power have been limited to the mJ and the GW level, respectively. A major difficulty in the further energy scaling of OPA results from a lack of suitable large nonlinear crystals. Here, we circumvent this difficulty by employing a dual-chirped optical parametric amplification (DC-OPA) scheme. We successfully generate a multi-TW IR femtosecond laser pulse with an energy of 100 mJ order, which is higher than that reported in previous works. We also obtain excellent energy scaling ability, ultrashort pulses, flexiable wavelength tunability, and high-energy stability, which prove that DC-OPA is a superior method for the energy scaling of IR pulses to the 10 J/PW level.
The Effect of Matrix Toughness on Delamination: Static and Fatigue Fracture Under Mode II Shear Loading of Graphite Fiber Composites (1987)

Both the static and fatigue behavior of delaminations subjected to pure Mode II shear loading were investigated using end-delaminated flexure specimens. By carrying out the constant amplitude sine-wave fatigue tests at fatigue load ratios (R) of R = 0 and R = −1, the importance of shear reversal was evaluated. The effect of improved matrix toughness on the Mode II properties was determined by testing four different graphite fiber composite systems having widely different Mode I fracture energies. The results indicated that the benefits of improved matrix toughness on the composite properties were less under Mode II loading than under Mode I and were reduced further still, or eliminated entirely, under Mode II fatigue conditions. It was found also that full shear reversal had an accelerating effect on the Mode II fatigue crack growth rates, especially at low values of ΔGII. These findings are discussed in terms of the failure mechanisms taking place. The significance of the results to damage tolerance and long-term durability design considerations are also addressed.
Design and Operation of a Pulse-Number Multiplier for a High-Precision RSFQ D/A Converter (2005)

A pulse-number multiplier (PNM) is a principal subsystem of our rapid single flux quantum digital-to-analog converter for metrology applications. The PNM circuit generates a high-speed pulse train from an input of a precise low-frequency clock signal. We designed, fabricated, and successfully tested a PNM test circuit. The PNM test circuit was implemented by using our standard cell library on 1.6 kA/cm/sup 2/ Nb trilayer technology. Fully functional operation was confirmed by low-speed testing. Experimental bias margins were wider than /spl plusmn/20%, and these results agreed with a simulation. We also tested the circuit by average-voltage measurements for estimating the frequencies of output pulse trains. Results of average-voltage measurements implied that the output frequency of the PNM circuit was tunable from 5 GHz to 17 GHz. The bit error rate (BER) of the PNM circuit was measured, and extrapolation of the error-function fits suggested a sufficiently small BER at the optimum bias point.