gebhart/patrepeval huggingface dataset:
Phase-controlled series-parallel resonant converter (1993)

A constant-frequency, phase-controlled, series-parallel resonant DC-DC converter is introduced, analyzed in the frequency domain, and experimentally verified. To obtain the DC-DC converter, two identical series-parallel resonant inverters are paralleled and the resulting phase-controlled resonant inverter is loaded by a voltage-driven rectifier. The converter can regulate the output voltage at a constant switching frequency in the range of load resistance from full-load resistance to infinity while maintaining good part-load efficiency. The efficiency of the converter is almost independent of the input voltage. For switching frequencies slightly above the resonant frequency, power switches are always inductively loaded, which is very advantageous if MOSFETs are used as switches. Experimentally results are given for a converter with a center-tapped rectifier at an output power of 52 W and a switching frequency of 127 kHz. The measured current imbalance between the two inverters was as low as 1.2:1.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Allogeneic Human Mesenchymal Stem Cells Restore Epithelial Protein Permeability in Cultured Human Alveolar Type II Cells by Secretion of Angiopoietin-1* (2010)

Acute lung injury is characterized by injury to the lung epithelium that leads to impaired resolution of pulmonary edema and also facilitates accumulation of protein-rich edema fluid and inflammatory cells in the distal airspaces of the lung. Recent in vivo and in vitro studies suggest that mesenchymal stem cells (MSC) may have therapeutic value for the treatment of acute lung injury. Here we tested the ability of human allogeneic mesenchymal stem cells to restore epithelial permeability to protein across primary cultures of polarized human alveolar epithelial type II cells after an inflammatory insult. Alveolar epithelial type II cells were grown on a Transwell plate with an air-liquid interface and injured by cytomix, a combination of IL-1beta, TNFalpha, and IFNgamma. Protein permeability measured by (131)I-labeled albumin flux was increased by 5-fold over 24 h after cytokine-induced injury. Co-culture of human MSC restored type II cell epithelial permeability to protein to control levels. Using siRNA knockdown of potential paracrine soluble factors, we found that angiopoietin-1 secretion was responsible for this beneficial effect in part by preventing actin stress fiber formation and claudin 18 disorganization through suppression of NFkappaB activity. This study provides novel evidence for a beneficial effect of MSC on alveolar epithelial permeability to protein.
Thickness and polarization dependence of the magnetooptic signal from ultrathin ferromagnetic films (1989)

Longitudinal Kerr-effect measurements using both s- and p-polarized light are presented as a function of thickness for bcc Fe films grown epitaxially on Au(100) in ultrahigh vacuum (UHV). The motivation is to explore the origins of the magnetooptic response at Fe thicknesses comparable to the depth penetration of light. Special efforts were taken to optically compensate for the birefringence of the UHV window. The compensated measurements yield the magnitude of the complex rotation ${\ensuremath{\varphi}}_{m}$=(\ensuremath{\varphi}${\mathcal{'}}^{2}$+\ensuremath{\varphi}'${\mathcal{'}}^{2}$${)}^{1/2}$, where \ensuremath{\varphi}' and \ensuremath{\varphi}'' are the real magnetooptic rotation and the ellipticity, respectively. The results show linear initial increase of ${\ensuremath{\varphi}}_{m}$ with thickness (up to the optical penetration depth) followed by a shallow peak and leveling off to a saturation value of the thick-film Kerr rotation. A review of the relevant theory includes the Faraday and Kerr contributions to the magnetooptic response. The Faraday contribution arises from metallic reflection from the substrate and passage back through the iron overlayer. We argue that the Faraday effect dominates the response in the ultrathin limit, while the Kerr effect controls the thick-film regime.
Fabrication of a Practical and Polymer‐Rich Organic Radical Polymer Electrode and its Rate Dependence (2008)

Abstract A practical and polymer‐rich organic radical cathode that contains 80 wt.‐% poly(4‐vinyloxy‐2,2,6,6‐tetramethylpiperidine‐ N ‐oxyl) (PTVE) and 15 wt.‐% vapor‐grown carbon fiber (VGCF) has been fabricated. The PTVE/VGCF composite electrode shows a reversible redox peak at 3.56 V (vs Li/Li + ) in cyclic voltammetry. A coin‐type cell with the PTVE/VGCF composite electrode as the cathode and lithium metal as the anode has also been fabricated and used for charge/discharge measurements. When the cell was discharged at 0.3 mA · cm −2 (1 C), a capacity of 104 mAh · g −1 , which is 77% of PTVE's theoretical capacity (135 mAh · g −1 ), was obtained. When it was discharged at 9.0 mA · cm −2 (30 C), its capacity was 52% of the capacity it had when it was discharged at 0.3 mA · cm −2 (1 C). Even when discharged at 24 mA · cm −2 (80 C), it surprisingly had 32% of the capacity it had when discharged at 0.3 mA · cm −2 . The observed rate dependence shows that the polymer‐rich electrode could discharge over 50% of the cell capacity in two minutes and over 30% within one minute. magnified image
Class Conditional Nearest Neighbor for Large Margin Instance Selection (2009)

This paper presents a relational framework for studying properties of labeled data points related to proximity and labeling information in order to improve the performance of the 1NN rule. Specifically, the class conditional nearest neighbor (ccnn) relation over pairs of points in a labeled training set is introduced. For a given class label c, this relation associates to each point a its nearest neighbor computed among only those points with class label c (excluded a). A characterization of ccnn in terms of two graphs is given. These graphs are used for defining a novel scoring function over instances by means of an information-theoretic divergence measure applied to the degree distributions of these graphs. The scoring function is employed to develop an effective large margin instance selection method, which is empirically demonstrated to improve storage and accuracy performance of the 1NN rule on artificial and real-life data sets.
Assessment of Accidental Intakes of Uranyl Acetylacetonate (UAA) (1994)

Uranyl acetylacetonate (UAA) is an organic complex of uranium used for military applications as a chemical catalyst in high explosives. It is prepared from depleted uranium metal (in lots of 5 kg to 7 kg) by dissolution in nitric acid, z._eutralization,and complexation with 2,4-pentanedione; the precipitate is dissolved in benzene and recrystallized, dried, ground, and packaged. About six workers at a small chemical company were exposed over a period of time to UAA powders during routine preparation and packaging of the uranium catalyst. The dissolution characteristics of the inhaled material were unknown and could not be determined from the published scientific literature. A 1.05-g sample of UAA powder was obtained from the responsible
Malignant transformation of human fibroblast cell strain MSU-1.1 by (+-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo [a]pyrene. (1992)

Treatment of MSU-1.1 cells, a near-diploid, karyotypically stable, infinite life-span human fibroblast strain, with (+-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene induced focus formation. Eight independent foci were isolated and the cell strains developed from them were examined for characteristics of malignant cells. Each grew to a higher density in medium containing 1% serum than did the MSU-1.1 cells. Three of the eight grew rapidly in serum-free medium without added growth factors, formed colonies in agarose with diameters of greater than or equal to 120 microns at a frequency of 5-19%, exhibited loss of genetic material, and, when injected into athymic mice, formed sarcomas that reached 6 mm in diameter within 2-3 wk. One produced high-grade sarcomas (progressively growing, invasive tumors exhibiting high mitotic activity); the other two produced low-grade sarcomas (tumors with a lower degree of mitotic activity) that developed focal areas of high-grade malignant cells if left in the animals for greater than 4 wk. A fourth cell strain formed high-grade sarcomas only after 2.5-3 mo, but the tumor-derived cells analyzed showed the same growth properties as the three malignant cell strains described above, exhibited loss of genetic material, and, when reinjected into athymic mice, produced high-grade sarcomas with a short latency period.
Contextual Topic Model Based Image Recommendation System (2015)

With the incredibly growing amount of image data uploaded and shared via the internet, recommender systems have become an important necessity to ease users' burden on the information overload. Existing image recommendation systems are designed for discovering the most relevant images with a given query image or short query composed by a few words. However, none of them considers deal with long query, where the query could in any length and potentially contains multiple query topics. To address this problem, we present a contextual topic model based image recommendation system. Compared to using a search engine such as Google Image, our system has the advantage of being able to discern among different topics within a long text query and recommend the most relevant images for each detected topic with semantic "visual words" based relevance.
Human Ciliary Muscle Cell Responses to FP-Class Prostaglandin Analogs: Phosphoinositide Hydrolysis, Intracellular Ca <sup>2+</sup> Mobilization and MAP Kinase Activation (2003)

Phospholipase C induced phosphoinositide (PI) turnover, intracellular Ca(2+) ([Ca(2+)](i)) mobilization and mitogen-activated protein (MAP) kinase activation by FP-class prostaglandin analogs was studied in normal human ciliary muscle (h-CM) cells. Agonist potencies obtained in the PI turnover assays were: travoprost acid ((+)-fluprostenol; EC(50) = 2.6 +/- 0.8 nM) > bimatoprost acid (EC(50) = 3.6 +/- 1.2 nM) > (+/-)-fluprostenol (EC(50) = 4.3 +/- 1.3 nM) >> prostaglandin F(2 alpha) (PGF(2 alpha)) (EC(50) = 134 +/- 17 nM) > latanoprost acid (EC(50) = 198 +/- 83 nM) > S-1033 (EC(50) = 2930 +/- 1420 nM) > unoprostone (EC(50) = 5590 +/- 1490 nM) > bimatoprost (EC(50) = 9600 +/- 1100 nM). Agonist potencies in h-CM cells correlated well with those previously obtained for the cloned human ciliary body-derived FP receptor (r = 0.96, p< 0.001) and that present on h-TM cells (r = 0.94, p< 0.0001). Travoprost acid, PGF(2 alpha) and unoprostone also stimulated [Ca(2+)](i) mobilization in h-CM cells with travoprost acid being the most potent agonist. MAP kinase activity was stimulated in the h-CM cells with the following rank order of activity (at 100 nM): travoprost acid > PGF(2 alpha) > latanoprost acid > PGD(2) > bimatoprost > latanoprost = bimatoprost acid = fluprostenol > PGE(2) = S-1033 > unoprostone > PGI(2). The PI turnover, [Ca(2+)](i) mobilization and MAP kinase activation induced by several of these agonists was blocked by the FP receptor antagonist, AL-8810 (11 beta-fluoro-15-epiindanyl PGF(2 alpha)) (e.g. K(i) = 5.7 microM versus PI turnover). These studies have characterized the biochemical and pharmacological properties of the native FP prostaglandin receptor present on h-CM cells using three signal transduction mechanism assays and a broad panel of FP-class agonist analogs (including free acids of bimatoprost, travoprost and latanoprost) and the FP receptor antagonist, AL-8810.
Tungsten dichalcogenides (WS<sub>2</sub>, WSe<sub>2</sub>, and WTe<sub>2</sub>): materials chemistry and applications (2017)

Tungsten is the heaviest transition metal in the family of common transition metal dichalcogenides (TMDCs).
Tyrosine kinase inhibition in bone metabolism. (2000)

Inhibition of tyrosine kinase signaling has become increasingly important as a therapeutic approach for a variety of diseases, initially for cancer, but also for inflammatory and non-malignant hyperproliferative diseases (psoriasis) amongst others. Recently, inhibitors of the tyrosine kinase c-Src, have for the first time been shown to reduce bone loss after estrogen withdrawal in an animal model of osteoporosis. Here we review the current state of knowledge on the effects of tyrosine kinase inhibition on bone metabolism with a particular emphasis on inhibitors of c-Src.
Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG (2012)

Triolimus is a first-in-class, multidrug-loaded micelle containing paclitaxel, rapamycin, and 17-AAG. In this study, we examine the antitumor mechanisms of action, efficacy, and toxicity of Triolimus in vitro and in vivo. In vitro cytotoxicity testing of Triolimus was conducted using two aggressive adenocarcinomas including the lung cancer cell line, A549, and breast cancer cell line, MDA-MB-231. The three-drug combination of paclitaxel, rapamycin, and 17-AAG displayed potent cytotoxic synergy in both A549 and MDA-MB-231 cell lines. Mechanistically, the drug combination inhibited both the Ras/Raf/mitogen-activated protein kinase and PI3K/Akt/mTOR pathways. Triolimus was advanced into tumor xenograft models for assessment of efficacy, toxicity, and mechanisms of action. In vivo, a three-infusion schedule of Triolimus inhibited A549 and MDA-MB-231 tumor growth far more potently than paclitaxel-containing micelles and effected tumor cures in MDA-MB-231 tumor-bearing animals. Tumor growth delays resulted from a doubling in tumor cell apoptosis and a 50% reduction in tumor cell proliferation compared with paclitaxel-containing micelles. Enhanced antitumor efficacy was achieved without clinically significant increases in acute toxicity. Thus, Triolimus displays potent synergistic activity in vitro and antitumor activity in vivo with comparable toxicity to paclitaxel. These observations provide strong support for further development of Triolimus and an important proof of concept for safe, effective nanoparticle-based delivery of three complementary anticancer agents.
Application of the hydro(solvento)thermal technique to the synthesis of metal carbonyl chalcogenide clusters. 2. Synthesis and x-ray structures of [[Fe4Te4(CO)10]2(Te2)]2- and [[Fe2Se(CO)6]2(Se2)]2- (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of the hydro(solvento)thermal technique to the synthesis of metal carbonyl chalcogenide clusters. 2. Synthesis and x-ray structures of [[Fe4Te4(CO)10]2(Te2)]2- and [[Fe2Se(CO)6]2(Se2)]2-Song Ping Huang and Mercouri G. KanatzidisCite this: Inorg. Chem. 1993, 32, 6, 821–825Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://doi.org/10.1021/ic00058a012RIGHTS & PERMISSIONSArticle Views102Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (593 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Ecological issue of polymer flame retardancy (2002)

Abstract The use of polymer flame retardants has an important role in saving lives. The main flame retardant systems for polymers currently in use are based on halogenated, phosphorous, nitrogen, and inorganic compounds. All of these flame retardant systems basically inhibit or even suppress the combustion process by chemical or physical action in the gas or condensed phase. Conventional flame retardants, such as halogenated, phosphorous, or metallic additives, have a number of negative attributes. An ecological issue of the application of conventional flame retardants demands the search of new polymer flame retardant systems. Among the new trends of flame retardancy are intumescent systems, polymer nanocomposites, preceramic additives, low‐melting glasses, different types of char formers, and polymer morphology modification processing. The brief explanations on the three major types of flame retardant systems (intumescent systems, polymer nanocomposites, and polymer organic char formers) are the subject of this overview. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 2449–2462, 2002
α-Synuclein Can Function as an Antioxidant Preventing Oxidation of Unsaturated Lipid in Vesicles (2006)

Alpha-synuclein, a presynaptic protein associated with Parkinson's disease, is found as both soluble cytosolic and membrane-bound forms. Although the function of alpha-synuclein is unknown, several observations suggest that its association with membranes is important. In the present study we investigated the effect of alpha-synuclein on lipid oxidation in membranes containing phospholipids with unsaturated fatty acids. The kinetics of lipid oxidation were monitored by the change in fluorescence intensity of the dye C11-BODIPY. We find that monomeric alpha-synuclein efficiently prevented lipid oxidation, whereas fibrillar alpha-synuclein had no such effect. Our data suggest that the prevention of unsaturated lipid oxidation by alpha-synuclein requires that it bind to the lipid membrane. The antioxidant function of alpha-synuclein is attributed to its facile oxidation via the formation of methionine sulfoxide, as shown by mass spectrometry. These findings suggest that the inhibition of lipid oxidation by alpha-synuclein may be a physiological function of the protein.
Supporting user-defined activity spaces (1997)

Activity spaces are usually task-specific and only common to a group of people who work together in a certain application domain. It is desirable to enable users to define and modify activity spaces according to their needs. However, many users are unable to use a pre-defined activity space correctly or incapable of formally defining an activity space. This work tries to solve these problems 1) by developing a flexible hypertext meta-model which can represent activity space semantics, 2) developing an example-based definition tool for users to create task-specific activity spaces, 3) providing intelligent aid in using these activity spaces, and 4) providing a flexible space for adopting existing and emergent patterns. A system (COWFISH) with the above components has been implemented and tested at GMD-IPSI. Examples and initial applications have shown that using the system users can easily define the schemata of many activity spaces and hyperdocuments. They can also create new activity spaces with stepwise structure transformation and through reusing existing activity spaces. The system then uses the schema knowledge to maintain the semantic consistency of the activity space instances and to provide users with context-sensitive examples, choices, and explanations.
Mac Ball and anti-anti-communism (2013)

Best known for his early championing of Australia's role in Asia, Professor William Macmahon Ball (1901-86) was Australia's first Professor of Political Science when appointed to the post at the University of Melbourne in 1949. Mac Ball, as he was known, began as a tutor in Psychology and Philosophy, but moved to Political Science after a stint under Professor Harold Laski at the London School of Economics (LSE). He also became well known because of his two additional careers. He was a fluent foreign affairs commentator on ABC radio and in the Melbourne Herald. In addition he was appointed by the federal government during the 1940s to four important posts: controller of broadcasting during the war; part of the Australian delegation to the 1945 San Francisco conference which founded the United Nations; special observer to postwar Netherlands East Indies; and in 1946 Commonwealth representative on the Allied Council for Japan in Tokyo. The author of this biography, who is Japanese, has a fascinating chapter on the workings of the Allied Council, its relations with General Douglas MacArthur, and Mac Ball's role on the Council.
Efficient Combining Scheme of Scheduling and Channel Allocation in Multi-Channel Systems (2007)

SUMMARY In this letter, we propose an efficient scheme for combining scheduling and channel allocation functions in multi-channel systems such as an orthogonal frequency division multiple access (OFDMA). In our approach, the scheduling function is embedded in the channel allocation function in an implicit manner, and the implicit scheduler only translates quality-of-service (QoS) requirements into a set of constraints on channel allocation. The channel allocation problem is then formulated as a linear programming (LP) problem, and the optimal solution can be easily obtained through various LP algorithms. Through extensive numerical experiments, it is demonstrated that the proposed scheme can maximize the cell throughput under the given QoS requirements.
Structural Diversity of Triplet Repeat RNAs (2010)

Tandem repeats of various trinucleotide motifs are present in the human transcriptome, but the functions of these regular sequences, which likely depend on the structures they form, are still poorly understood. To gain new insight into the structural and functional properties of triplet repeats in RNA, we have performed a biochemical structural analysis of the complete set of triplet repeat transcripts, each composed of a single sequence repeated 17 times. We show that these transcripts fall into four structural classes. The repeated CAA, UUG, AAG, CUU, CCU, CCA, and UAA motifs did not form any higher order structure under any analyzed conditions. The CAU, CUA, UUA, AUG, and UAG repeats are ordered according to their increasing tendency to form semistable hairpins. The repeated CGA, CGU, and all CNG motifs form fairly stable hairpins, whereas AGG and UGG repeats fold into stable G-quadruplexes. The triplet repeats that formed the most stable structures were characterized further by biophysical methods. UV-monitored structure melting revealed that CGG and CCG repeats form, respectively, the most and least stable hairpins of all CNG repeats. Circular dichroism spectra showed that the AGG and UGG repeat quadruplexes are formed by parallel RNA strands. Furthermore, we demonstrated that the different susceptibility of various triplet repeat transcripts to serum nucleases can be explained by the sequence and structural features of the tested RNAs. The results of this study provide a comprehensive structural foundation for the functional analysis of triplet repeats in transcripts.