gebhart/patrepeval huggingface dataset:
Factored conditional restricted Boltzmann Machines for modeling motion style (2009)

The Conditional Restricted Boltzmann Machine (CRBM) is a recently proposed model for time series that has a rich, distributed hidden state and permits simple, exact inference. We present a new model, based on the CRBM that preserves its most important computational properties and includes multiplicative three-way interactions that allow the effective interaction weight between two units to be modulated by the dynamic state of a third unit. We factor the three-way weight tensor implied by the multiplicative model, reducing the number of parameters from O(N3) to O(N2). The result is an efficient, compact model whose effectiveness we demonstrate by modeling human motion. Like the CRBM, our model can capture diverse styles of motion with a single set of parameters, and the three-way interactions greatly improve the model's ability to blend motion styles or to transition smoothly among them.
Understanding Hepatitis B Virus Infection (1995)

Infection with hepatitis B virus (HBV) results in a broad spectrum of liver disease, ranging from subclinical infection to acute, self-limited hepatitis and fatal, fulminant hepatitis. Exposure to HBV, particularly when it occurs early in life, may also result in an asymptomatic carrier state that can progress to chronic active hepatitis, cirrhosis of the liver, and eventually hepatocellular carcinoma. Complex viral and host factors determine this variable clinical outcome. Fundamental questions about the biologic aspects of hepatitis B that have direct relevance to clinical practice remain unresolved. It is estimated that there are 400 to 500 million HBV carriers in . . .
A noise-shifting differential Colpitts VCO (2002)

A novel noise-shifting differential Colpitts VCO is presented. It uses current switching to lower phase noise by cyclostationary noise alignment and improve the start-up condition. A design strategy is also devised to enhance the phase noise performance of quadrature coupled oscillators. Two integrated VCOs are presented as design examples.
Expression and Characterization of the<i>Mycobacterium tuberculosis</i>Serine/Threonine Protein Kinase PknB (1999)

PknB is a member of the newly discovered eukaryotic-like protein serine/threonine kinase (PSTK) family of proteins. The pknB gene was cloned and expressed in Escherichia coli. The active recombinant protein was purified and shown to be reactive with antiphosphoserine antibodies, as well as with antibodies to the phosphorylated eukaryotic Ser/Thr kinases mitogen-activated protein kinase kinase 3 and 6, P38, and Creb. In vitro kinase assays demonstrated that PknB is a functional kinase that is autophosphorylated on serine/threonine residues and is also able to phosphorylate the peptide substrate myelin basic protein. Analysis of pknB expression in Mycobacterium tuberculosis indicates the presence of pknB mRNA in (i) organisms grown in vitro in bacteriological media, (ii) a murine macrophage in vitro infection model, and (iii) in vivo alveolar macrophages from a patient with tuberculosis.
A 2.1 mW 11b 410 MS/s dynamic pipelined SAR ADC with background calibration in 28nm digital CMOS (2013)

A 410 MS/s 2x interleaved 11bit pipelined SAR ADC in 28nm digital CMOS is presented. Each ADC channel consists of a 6b coarse SAR, a dynamic residue amplifier and a 7b fine SAR and includes an on-chip calibration engine that detects and corrects comparator offsets and amplifier gain errors in the background. The ADC achieves a peak SNDR of 59.8 dB at 410 MS/s for an energy per conversion step of 6.5 fJ.
Electric Charge of Antibodies (1933)

Abstract A number of investigators have studied the nature of electric charge of antibodies, especially of agglutinins. Landsteiner and Pauli (1908) were the first to record from cataphoresis experiments that the haemagglutinin of chicken serum carries a negative charge in neutral and alkaline solution and a positive charge in acid solution. Michaelis and Davidsohn (1912) determined the isoelectric point of various antibodies. They found the isoelectric point of agglutinins for B. typhosus to be between (H·) 1.0 × 10-6 and 5.1 × 10-6 and for precipitins between 3 × 10-6 and 6 × 10-6. From that they concluded that the antibodies are amphoteric and that their isoelectric point is identical with that of the globulins, that is (H·) 4 × 10-6. Recently Vera Schroeder (1930) found that the isoagglutinins are amphoteric proteins with an isoelectric point at pH 4.0.
Conversion of small functional test sets of nonscan blocks to scan patterns (2002)

Testing nonscan blocks of hardware such as small embedded memories (register files, etc.) can be done using existing scan chains due to the atypically small memory size. FastScan's Macrotest has been developed to solve this problem, and the more interesting problem of concisely and accurately informing the user about the specific hardware and command constraints which prevent successful testing. This allows the user to quickly identify the particular problems, and add DFT or change the patterns to match the architectural and other restraints of the embedding.
A Dynamic Resolution Method for Feature Interactions and Its Evaluation. (1995)

This study examines the effects on nursing home nurses of a two-day training program concerned with nurses and their response to the dying patient. Utilizing the Solomon four-group design, the study investigates whether exposure to information on death and dying (a) results in the acquisition of greater knowledge about death and dying, (b) is accompanied by a more positive attitude toward the elderly, and (c) is accompanied by a change in anxiety about death. Based on t tests and one-way analyses of covariance, the results point up the mixed nature of short-term training programs. It was found that there was a significant increase in the nurses' knowledge about death and dying, there was no change in their attitudes toward the elderly, and there was a significant increase among the nurses in the death anxiety experienced. This is not to suggest that training programs of this sort should not be conducted with nursing home staff. On the one hand such programs provide information useful for job performance. On the other hand they create some sensitization to death, which at the very least could give nurses greater insights into the concerns of the patients and perhaps stimulate empathetic responses.
PALLADIUM-CATALYZED AROMATIC AMINATION OF ARYL BROMIDES WITH <i>N</i>,<i>N</i>-DI-ETHYLAMINO-TRIBUTYLTIN (1983)

Abstract The reaction of N,N-diethylamino-tributyltin with aryl bromides in the presence of a catalytic amount of PdCl2(o-tolyl3P)2 gave N,N-diethylaminobenzene derivatives. The reaction is a new kind of amination different from ones through aryne or SRN1 mechanise
Explicit Context Matching in Content-Based Publish/Subscribe Systems (2013)

Although context could be exploited to improve performance, elasticity and adaptation in most distributed systems that adopt the publish/subscribe (P/S) communication model, only a few researchers have focused on the area of context-aware matching in P/S systems and have explored its implications in domains with highly dynamic context like wireless sensor networks (WSNs) and IoT-enabled applications. Most adopted P/S models are context agnostic or do not differentiate context from the other application data. In this article, we present a novel context-aware P/S model. SilboPS manages context explicitly, focusing on the minimization of network overhead in domains with recurrent context changes related, for example, to mobile ad hoc networks (MANETs). Our approach represents a solution that helps to effciently share and use sensor data coming from ubiquitous WSNs across a plethora of applications intent on using these data to build context awareness. Specifically, we empirically demonstrate that decoupling a subscription from the changing context in which it is produced and leveraging contextual scoping in the filtering process notably reduces (un)subscription cost per node, while improving the global performance/throughput of the network of brokers without altering the cost of SIENA-like topology changes.
Common Desktop Environment 1.0 Programmer's Guide (1995)

From the Publisher:
makes applications running on UNIX systems portable and easy to use. Developed by IBM, Hewlett-Packard, SunSoft, and Novell, CDE is becoming a defacto standard in the UNIX marketplace because it unites different platforms under a single user interface. 
The Common Desktop Environment Technical Library is the official documentation for users, system administrators, and application developers of this exciting new technology.
Microcrystalline silicon thin-film solar cells prepared at low temperature using RF-PECVD (2002)

Hydrogenated microcrystalline silicon (/spl mu/c-Si:H) p-i-n solar cells have been prepared using a conventional RF-plasma-enhanced chemical vapor deposition (PECVD) method at a low process temperature of 140/spl deg/C. Low temperature deposition is effective to suppress the formation of oxygen-related donors that cause a reduction in open circuit voltage (Voc) by shunt leakage. We demonstrate the improvement of Voc by lowering the deposition temperature down to 140/spl deg/C with maintaining high short circuit current density (Jsc) and fill factor (FF). An efficiency of 8.9% was obtained using an Aasahi-U substrate. Further optimization of texture of transparent conductive oxide (TCO) substrate has been developed by using ZnO, and the highest efficiency of 9.4% (Voc=0.526 V, Jsc=25.3 mA/cm/sup -1/, FF-0.710) in our study was obtained on ZnO substrate textured by etching process. Limiting factors of solar cell performance are discussed based on the growth mechanism of /spl mu/c-Si:H.
<scp>EU</scp>Merger Guidelines (2015)

Abstract This article provides a description of the 2004 EU guidelines for horizontal mergers and the 2008 guidelines developed to examine nonhorizontal (vertical and conglomerate) mergers. The process by which the regulatory authorities examine these mergers is identified, as are parallels and emerging differences between these and the more recently adopted US merger guidelines. The economic methods and evidence involved in examining possible coordinated and noncoordinated anticompetitive effects of a merger are highlighted, as are the regulatory commission's definition and measurement of market boundaries and market concentration. The practical importance of these guidelines to the business community is also discussed.
Versatile Dual-Technology System for Markerless Allele Replacement in <i>Burkholderia pseudomallei</i> (2009)

Burkholderia pseudomallei is the etiologic agent of melioidosis, a rare but serious tropical disease. In the United States, genetic research with this select agent bacterium is strictly regulated. Although several select agent compliant methods have been developed for allelic replacement, all of them suffer from some drawbacks, such as a need for specific host backgrounds or use of minimal media. Here we describe a versatile select agent compliant allele replacement system for B. pseudomallei based on a mobilizable vector, pEXKm5, which contains (i) a multiple cloning site within a lacZalpha gene for facile cloning of recombinant DNA fragments, (ii) a constitutively expressed gusA indicator gene for visual detection of merodiploid formation and resolution, and (iii) elements required for resolution of merodiploids using either I-SceI homing endonuclease-stimulated recombination or sacB-based counterselection. The homing endonuclease-based allele replacement system is completed by pBADSce, which contains an araC-P(BAD)-I-sceI expression cassette for arabinose-inducible I-SceI expression and a temperature-sensitive pRO1600 replicon for facile plasmid curing. Complementing these systems is the improved Deltaasd Escherichia coli mobilizer strain RHO3. This strain is susceptible to commonly used antibiotics and allows nutritional counterselection on rich media because of its diaminopimelic acid auxotrophy. The versatility of the I-SceI- and sacB-based methods afforded by pEXKm5 in conjunction with E. coli RHO3 was demonstrated by isolation of diverse deletion mutants in several clinical, environmental, and laboratory B. pseudomallei strains. Finally, sacB-based counterselection was employed to isolate a defined chromosomal fabD(Ts) allele that causes synthesis of a temperature-sensitive FabD, an essential fatty acid biosynthesis enzyme.
Cyclizations of Dialdehydes with Nitromethane. XII.<sup>1</sup> o-Phthalaldehyde<sup>2</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclizations of Dialdehydes with Nitromethane. XII.1 o-Phthalaldehyde2Hans Helmut Baer and Barbara AchmatowiczCite this: J. Org. Chem. 1964, 29, 11, 3180–3185Publication Date (Print):November 1, 1964Publication History Published online1 May 2002Published inissue 1 November 1964https://pubs.acs.org/doi/10.1021/jo01034a014https://doi.org/10.1021/jo01034a014research-articleACS PublicationsRequest reuse permissionsArticle Views219Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gel and liquid-crystal phase structures of the trioxyethylene glycol monohexadecyl ether/water system (1984)

Optical microscopy, differential scanning calorimetry, small-angle X-ray diffraction and nuclear magnetic resonance spectroscopy have been used to study the lyotropic phases formed by trioxyethylene glycol monohexadecyl ether with water (2H2O). The phase diagram exhibits regions corresponding to lamellar (Lα), inverse cubic [V2(1), V2(2)], gel (Lβ) and isotropic liquid phases (W, L2, L3). The two V2 phases were identified by both optical microscopy and small-angle X-ray measurements. The gel phase exhibits a large melting entropy, and part of the molecule has a much restricted mobility. Low-angle X-ray data indicate that the alkyl chains are ordered, with a thickness equivalent to one hydrocarbon chain length. Taken together these data confirm a monolayer ‘interdigitated’ alkyl chain structure for the gel. In the presence of water the gel is stable (at thermodynamic equilibrium) below 40 °C. Anhydrous C16EO3 exhibits polymorphic phase behaviour. After melting the crystalline surfactant, a metastable gel structure forms on cooling and the crystalline solid reforms only after lengthy storage at low temperature. The maximum water-layer thickness of the Lα phase is larger than that of Lβ despite the expected weaker inter-layer attractions in the latter case. This implies the existence of an additional repulsion in Lα, possibly arising from elastic undulations of liquid bilayers.
Changes in tumor vascularization after irradiation, anthracyclin, or antiangiogenic treatment in nitrosomethyl ureas-induced rat mammary tumors. (2003)

Changes in functional tumor vascularization evolution appeared to be closely associated with tumor regression after anticancer treatment.
Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis (2014)

We studied the impact of driver mutations of JAK2, CALR, (calreticulin gene) or MPL on clinical course, leukemic transformation, and survival of patients with primary myelofibrosis (PMF). Of the 617 subjects studied, 399 (64.7%) carried JAK2 (V617F), 140 (22.7%) had a CALR exon 9 indel, 25 (4.0%) carried an MPL (W515) mutation, and 53 (8.6%) had nonmutated JAK2, CALR, and MPL (so-called triple-negative PMF). Patients with CALR mutation had a lower risk of developing anemia, thrombocytopenia, and marked leukocytosis compared with other subtypes. They also had a lower risk of thrombosis compared with patients carrying JAK2 (V617F). At the opposite, triple-negative patients had higher incidence of leukemic transformation compared with either CALR-mutant or JAK2-mutant patients. Median overall survival was 17.7 years in CALR-mutant, 9.2 years in JAK2-mutant, 9.1 years in MPL-mutant, and 3.2 years in triple-negative patients. In multivariate analysis corrected for age, CALR-mutant patients had better overall survival than either JAK2-mutant or triple-negative patients. The impact of genetic lesions on survival was independent of current prognostic scoring systems. These observations indicate that driver mutations define distinct disease entities within PMF. Accounting for them is not only relevant to clinical decision-making, but should also be considered in designing clinical trials.
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. (2000)

Bloom syndrome (BS) is characterized by genomic instability and cancer susceptibility caused by defects in BLM, a DNA helicase of the RecQ-family (J. German and N. A. Ellis, The Genetic Basis of Human Cancer, pp. 301-316, 1998). RecQ helicases and topoisomerase III proteins interact physically and functionally in yeast (S. Gangloff et al., Mol. Cell. Biol., 14: 8391-8398, 1994) and in Escherichia coli can function together to enable passage of double-stranded DNA (F. G. Harmon et al., Mol. Cell, 3: 611-620, 1999). We demonstrate in somatic and meiotic human cells an association between BLM and topoisomerase IIIalpha. These proteins colocalize in promyelocytic leukemia protein nuclear bodies, and this localization is disrupted in BS cells. Thus, mechanisms by which RecQ helicases and topoisomerase III proteins cooperate to maintain genomic stability in model organisms likely apply to humans.
Natural Product Biosynthesis:  A New Interface between Enzymology and Medicine (2000)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTNatural Product Biosynthesis: A New Interface between Enzymology and MedicineChaitan KhoslaView Author Information Departments of Chemistry, Chemical Engineering and Biochemistry, Stanford University, Stanford, California 94305-5025 Cite this: J. Org. Chem. 2000, 65, 24, 8127–8133Publication Date (Web):September 20, 2000Publication History Received2 June 2000Published online20 September 2000Published inissue 1 December 2000https://pubs.acs.org/doi/10.1021/jo000849yhttps://doi.org/10.1021/jo000849yreview-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views848Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biosynthesis,Genetics,Metabolism,Peptides and proteins,Pharmaceuticals Get e-Alerts
Bandwidth Extension of High Compliance Current Mirror by Using Compensation Methods (2014)

Due to the huge demand of high-speed analog integrated circuits, it is essential to develop a wideband low input impedance current mirror that can be operated at low power supply. In this paper, a novel wideband low voltage high compliance current mirror using low voltage cascode current mirror (LVCCM) as a basic building block is proposed. The resistive compensation and inductive peaking methods have been used to extend the bandwidth of the conventional current mirror. By replacing conventional LVCCM in a high compliance current mirror with the compensated LVCCM, the bandwidth extension ratio of 3.4 has been achieved with no additional DC power dissipation and without affecting its other performances. The circuits are designed in TSMC 0.18 μ m CMOS technology on Spectre simulator of Cadence.
A range/depth modulation transfer function (RMTF) framework for characterizing 3D imaging LADAR performance (2005)

3D imaging LADARs have emerged as the key technology for producing high-resolution imagery of targets in 3-dimensions (X and Y spatial, and Z in the range/depth dimension). Ball Aerospace & Technologies Corp. continues to make significant investments in this technology to enable critical NASA, Department of Defense, and national security missions. As a consequence of rapid technology developments, two issues have emerged that need resolution. First, the terminology used to rate LADAR performance (e.g., range resolution) is inconsistently defined, is improperly used, and thus has become misleading. Second, the terminology does not include a metric of the system’s ability to resolve the 3D depth features of targets. These two issues create confusion when translating customer requirements into hardware. This paper presents a candidate framework for addressing these issues. To address the consistency issue, the framework utilizes only those terminologies proposed and tested by leading LADAR research and standards institutions. We also provide suggestions for strengthening these definitions by linking them to the well-known Rayleigh criterion extended into the range dimension. To address the inadequate 3D image quality metrics, the framework introduces the concept of a Range/Depth Modulation Transfer Function (RMTF). The RMTF measures the impact of the spatial frequencies of a 3D target on its measured modulation in range/depth. It is determined using a new, Range-Based, Slanted Knife-Edge test. We present simulated results for two LADAR pulse detection techniques and compare them to a baseline centroid technique. Consistency in terminology plus a 3D image quality metric enable improved system standardization.
A new skate allowing powerful plantar flexions improves performance (1996)

To prevent the tip of the blade from scratching through the ice, the technique in speed skating requires that plantar flexion is largely suppressed during the gliding push off. This not only prevents the plantar flexors from contributing to external work but also causes the skater to lose contact with the ice long before the knee is fully extended. To prevent these disadvantages of the gliding technique, a new skate was developed that permits the shoe to rotate relative to the blade in a hinge between shoe and blade. In a case control study the progression between the 1993/1994 and 1994/1995 skating seasons of 11 male skaters from a regional junior selection who consented to switch to this new skate was compared with the progression of 72 skaters of this and all other regional and national male junior selections of The Netherlands. The experimental group appeared to improve their personal best times by 6.2 +/- 2.3%, which is a significantly (P < 0.001) larger progress than the 2.5 +/- 1.6% improvement of the control group. The new skate will therefore most likely add a new dimension to the art of speed skating.