gebhart/patrepeval huggingface dataset:
A design of automatically tunable active MOSFET‐RC filters using a single‐ended circuit structure (1990)

Abstract Recently, as a new continuous‐time filter, an automatic tuning MOSFET‐ C filter was proposed by Banu and Tsividis. It consists of MOSFETs, capacitors and operational amplifiers. It was shown that a highly accurate filter can be realized. In this configuration, only the voltage‐variable MOSFET resistor is used as the resistor and its non‐linearity is eliminated by a circuit configuration such as a fully balanced type. This paper proposes an active MOSFET‐ RC filter in which elimination of the nonlinearity of the MOSFET resistor does not require matching between MOSFETs. The filter consists of MOSFETs, capacitors, linear resistors with identical values and operational amplifiers, and can be made of a single‐ended circuit. An automatic tuning of the filter characteristics is possible via a control of the resistance value of the MOSFET resistor with a PLL made of a voltage‐controlled all‐pass filter. Based on this configuration, a third‐order elliptic low‐pass filter was constructed with discrete components. With a power supply voltage of ±5 V, the filter characteristics were a total harmonic distortion of less than 0.1 percent, a dynamic range of more than 110 dB, and a passband gain variation of less than ±0.1 dB in the temperature range of −20°C to 80°C for a filter input voltage of less than 5.3 V p−p .
Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members (2013)

Learning the biochemical function ofTMEM16family members is essential to understand their physiological role. Asymmetrical distribution of phospholipids between the inner and outer plasma membrane leaflets is disrupted in various biological processes. We recently identified TMEM16F, an eight-transmembrane protein, as a Ca(2+)-dependent phospholipid scramblase that exposes phosphatidylserine (PS) to the cell surface. In this study, we established a mouse lymphocyte cell line with a floxed allele in the TMEM16F gene. When TMEM16F was deleted, these cells failed to expose PS in response to Ca(2+) ionophore, but PS exposure was elicited by Fas ligand treatment. We expressed other TMEM16 proteins in the TMEM16F(-/-) cells and found that not only TMEM16F, but also 16C, 16D, 16G, and 16J work as lipid scramblases with different preference to lipid substrates. On the other hand, a patch clamp analysis in 293T cells indicated that TMEM16A and 16B, but not other family members, acted as Ca(2+)-dependent Cl(-) channels. These results indicated that among 10 TMEM16 family members, 7 members could be divided into two subfamilies, Ca(2+)-dependent Cl(-) channels (16A and 16B) and Ca(2+)-dependent lipid scramblases (16C, 16D, 16F, 16G, and 16J).
Preliminary results from a Phase I/II study of epacadostat (incb024360) in combination with pembrolizumab in patients with selected advanced cancers (2015)

Meeting abstracts Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan-catabolizing enzyme that is expressed in many cancers and induces immune tolerance by suppressing T cell responses. Epacadostat is a potent, selective oral inhibitor of IDO1. A dose-escalation study of epacadostat with
Ca2+-mediated generation of inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets. Studies with K+, glucose, and carbamylcholine. (1987)

The role of Ca2+ in the generation of inositol phosphates was investigated using rat pancreatic islets after steady state labeling with myo-[2-3H]inositol. Depolarizing K+ concentrations (24 mM) evoked early (2 s) increases in inositol 1,4,5-trisphosphate (Ins-1,4,5-P3) and inositol 1,3,4,5-tetrakisphosphate (Ins-1,3,4,5-P4) as measured by high performance anion-exchange chromatography. The increase in Ins-1,4,5-P3 was transient and was followed by a more pronounced rise in Ins-1,3,4-P3. These effects were dependent on the presence of extracellular Ca2+ but were not secondary to release of either neurotransmitters or metabolites of arachidonic acid. K+ also promoted the breakdown of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) and of the other phosphoinositides. Glucose (16.7 mM) was less marked in its effects but still promoted rapid increases in Ins-1,3,4,5-P4 (2 s) and Ins-1,4,5-P3 (10 s) and a slower rise in Ins-1,3,4-P3 (30 s). The levels of all three metabolites rose steadily over 10 min stimulation. These responses to glucose could be largely, although not entirely, inhibited by depletion of extracellular Ca2+ or by Ca2+ channel blockade with verapamil (20 microM). Carbamylcholine (0.5 mM) was the most potent stimulus used evoking early rises in Ins-1,4,5-P3 and Ins-1,3,4,5-P4 (2 s) followed by Ins-1,3,4-P3 (10 s), effects which were only partially dependent on extracellular Ca2+. The results suggest that a Ca2+-mediated PtdIns-4,5-P2 hydrolysis accounts for most of the Ins-1,4,5-P3 generated in response to glucose but not carbamylcholine. In addition, glucose may exert effects on inositol phosphate metabolism which are Ca2+ independent.
Activated Notch2 Potentiates CD8 Lineage Maturation and Promotes the Selective Development of B1 B Cells (2003)

Although studies have shown that the Notch2 family member is critical for embryonic development, little is known concerning its role in hematopoiesis. In this study, we show that the effects of an activated form of Notch2 (N2IC) on the T-cell lineage are dosage related. High-level expression of N2IC results in the development of T-cell leukemias. In contrast, lower-level expression of N2IC does not lead to transformation but skews thymocyte development to the CD8 lineage. Underlying this skew is a dramatic enhancement in positive selection and CD8SP maturation. N2IC permits early B-cell development but blocks the maturation of conventional B2 cells at the pre-B stage, which is the limit of endogenous Notch2 protein expression in developing B cells. Most strikingly, while B2 B cell development is blocked at the pre-B-cell stage, N2IC promotes the selective development of LPS-responsive B1 B cells. This study implicates a role for Notch2 in the maturation of the CD8 lineage and suggests a novel function for Notch2 in the development of the B1 B-cell subset.
Sports archives in Malaysia: the challenges and the way forward (2009)

Malaysia is considered a young independent nation with an ambitious vision of becoming a developed nation by the year under the Government's strategic Vision 2020 plan. In Malaysia, sport is a vital tool for uniting its multi-religious, multi-racial and multi-cultural people, and inspiring the young towards a more balanced and healthy lifestyle. With its population more focused on the present and the future, and on academic rather than sporting achievements, one of the main challenges for archives, particularly in sport, is to overcome the limited interest in history and lack of awareness of the necessity of archiving. The main way forward is by educating people to change their ‘use and discard’ mentality and realise the importance of long-term or permanent preservation of information and records which will preserve history and protect Malaysia's heritage in sports. The Olympic Council of Malaysia, the National Archives Malaysia and the Government of Malaysia, through the Ministry of Youth and Spor...
Influences on Video Poker Machine Performance (2002)

Abstract This study seeks to determine if slot machine performance levels are influenced by casino floor location and specific game characteristics. A Las Vegas hotel casino supplied the results of 418, $0.25, video poker machines, which were used to test hypotheses based on the findings of extant performance-potential research and casino management theory. Results from a simultaneous multiple regression model indicate that the core locations of the slot floor, featuring superior access and traffic volume, outperform the perimeter locations. Variables representing cabinet style (i.e., slant-top and bar-top units), par and program are also found to influence a machine's performance, at the .05 alpha level. The resulting equation offers an alternative performance measure that considers the unique operating parameters of a game, moving beyond basic performance comparisons of unit results to category averages (e.g., all $0.05 video poker games).
Effects of some carbohydrates on iron absorption. (1986)

Two experiments were performed to examine the effects of various carbohydrates (fructose, lactose, corn starch, wheat starch and potato starch) on the utilization of iron, on Fe-depleted rats. These received a single meal that contained the test carbohydrate at a 60% level, labelled with 59Fe. The rest of the experiment the rats were fed a diet which contained glucose at a 60% level as the carbohydrate source. In both experiments rats were fasted overnight, and the dose was offered in the form of a morning meal. To assay for 59Fe, the animals were counted in a "Whole body counter" between two and four hours after dosing, and every day for the following 10 days. Percentage retention and absorption, as well as hemoglobin values were determined. In the first experiment, the replacement of glucose by fructose at a 60% level enhanced significantly iron absorption and retention. An increase in absorption and retention also occurred when glucose was replaced by lactose at a 60% level, but the difference was not statistically significant. Administration of 59Fe as an 59Fe-fructose chelate did not seem to have a significant effect on retention and absorption when compared to the effect of dosing with 59Fe adsorbed onto a fructose diet. This not rule out the possibility that chelation is the mechanism responsible for the enhancing effect of fructose on iron utilization. The complex could have been formed in the stomach, resulting in a significant absorption for both the 59Fe-labelled meal and the 59Fe-carbohydrate complex-labelled meal. In the second experiment, administration of a meal that contained either of the starches resulted in a reduction on retention and absorption of 59Fe. The decrease, however, was statistically significant only for cooked corn starch, wheat starch and cooked wheat starch. The effect of cooking was to reduce even more the retention and absorption of 59Fe, but this reduction was statistically significant only for corn starch. The depressing effects of starches on iron retention and absorption are quite relevant to human nutrition. In the developing countries, diets are generally high in cereal products - often whole grain cereals - and low in animal products. The inhibitory effects of cereals on iron absorption have been traditionally attributed to the presence of phytates and fiber, but the data herein presented suggest that high intakes of starches may be inhibitory as well.
Police-community safety and trust. (2017)

(1)In 2017 alone, 46 states have enacted over 270 laws affecting policing. (2) At least six states have enacted laws to train the public on their rights and expectations during police interactions. (3) Police are increasingly partnering with health care professionals to more safely respond to mental health and substance use disorders.
High Expression of the Tonoplast Aquaporin <i>ZmTIP1</i>in Epidermal and Conducting Tissues of Maize1 (1998)

Aquaporins are integral membrane proteins of the tonoplast and the plasma membrane that facilitate the passage of water through these membranes. Because of their potentially important role in regulating water flow in plants, studies documenting aquaporin gene expression in specialized tissues involved in water and solute transport are important. We used in situ hybridization to examine the expression pattern of the tonoplast aquaporin ZmTIP1 in different organs of maize (Zea mays L.). This tonoplast water channel is highly expressed in the root epidermis, the root endodermis, the small parenchyma cells surrounding mature xylem vessels in the root and the stem, phloem companion cells and a ring of cells around the phloem strand in the stem and the leaf sheath, and the basal endosperm transfer cells in developing kernels. We postulate that the high level of expression of ZmTIP1 in these tissues facilitates rapid flow of water through the tonoplast to permit osmotic equilibration between the cytosol and the vacuolar content, and to permit rapid transcellular water flow through living cells when required.
Three Patterns of Catamenial Epilepsy (1997)

Charting of seizures and menses and determination of day 22 progesterone levels during each cycle may be sufficient to establish the existence of three distinct patterns of catamenial epilepsy. Approximately one third of women with intractable CPS may have catamenial epilepsy.
Ensemble Coordination Approach in Multi-AGV Systems Applied to Industrial Warehouses (2015)

This paper deals with a holistic approach to coordinate a fleet of automated guided vehicles (AGVs) in an industrial environment. We propose an ensemble approach based on a two layer control architecture and on an automatic algorithm for the definition of the roadmap. The roadmap is built by considering the path planning algorithm implemented on the hierarchical architecture and vice versa. In this way, we want to manage the coordination of the whole system in order to increase the flexibility and the global efficiency. Furthermore, the roadmap is computed in order to maximize the redundancy, the coverage and the connectivity. The architecture is composed of two layers. The low-level represents the roadmap itself. The high-level describes the topological relationship among different areas of the environment. The path planning algorithm works on both these levels and the subsequent coordination among AGVs is obtained exploiting shared resource (i.e., centralized information) and local negotiation (i.e., decentralized coordination). The proposed approach is validated by means of simulations and comparison using real plants. Note to Practitioners-The motivation of this work grows from the need to increase the flexibility and efficiency of current multi-AGV systems. In particular, in the current state-of-the-art the AGVs are guided through a manually defined roadmap with ad-hoc strategies for coordination. This is translated into high setup time requested for installation and the impossibility to easily respond to dynamic changes of the environment. The proposed method aims at managing all the design, setup and control process in an automatic manner, decreasing the time for setup and installation. The flexibility is also increased by considering a coordination strategy for the fleet of AGVs not based on manual ad-hoc rules. Simulations are performed in order to compare the proposed approach to the current industrial one. In the future, industrial aspects, as the warehouse management system, will be integrated in order to achieve a real and complete industrial functionality.
The future of the international railways of South America. A historical approach (1979)

In the closing decades of the last century and the first decades of the present century railways were regarded as an ideal means of linking the countries of America economically. Clear evidence of this aspiration is provided by the attempts —pursued over many years, but finally frustrated— to build a Pan-American Railway to link North, Central and South America, and the efforts of the Farquhar group to consolidate and link together railways in the southern part of the continent on the basis of control of the Brazil Railway Company.
Computed tomography scan assessment of lung volume and recruitment during high-frequency oscillatory ventilation (2005)

CT is a valuable tool to quantify recruitment and overinflation during HFOV. Additional studies are needed to better characterize the specific effects of HFOV on lung volume and morphology.
Surface Solid Dispersion – A Review (2013)

Preparation of an effective formulation of poorly water-soluble drugs is a key challenge in pharmaceutical technology. Dissolution rate and solubility are the rate- limiting steps for increasing the bioavailability of poorly water‐soluble drugs. Solid dispersion is an efficient technique for improving dissolution rate and subsequently, the bioavailability of poorly water‐soluble drugs. Surface sSolid dDispersion is a novel technique of solid dispersion for dispersing one or more active ingredients on a water insoluble carrier of high surface area in order to achieve increased dissolution rates and bioavailability of insoluble drugs. The Vvarious polymers used in this technique are Avicel, Crosspovidone, sSodium starch glycolate, pPregelatinized starch, Cab-o-sil, Ac-di-sol, KyronT-314, Primojel and pPotato sStarch. This article reviews the various methods of preparation and characterization of surface solid dispersion and compiles some of the drugs formulated as surface solid dispersions. Some of the practical aspects to be considered for preparing surface solid dispersion are selection of a suitable carrier and method of preparation of surface solid dispersion.
Pulse density modulation based power control of a 4 kW 400 kHz voltage-source invertor for induction heating applications (2002)

This paper presents a 4 kW 400 kHz voltage source inverter for induction heating applications, which is characterized by power control based on PDM (pulse density modulation). The pulse density modulated inverter makes an induction heating system simple and compact, thus leading to higher efficiency. The modulation strategy is proposed to realize an induction heating system capable of operation at the frequency and power level of interest. Some experimental results are shown to verify the validity of the concept.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
To Die or Not to Die: That is the Autophagic Question (2008)

Macroautophagy (commonly referred to as autophagy) is the process by which intact organelles and/or large portions of the cytoplasm are engulfed within double-membraned autophagic vacuoles for degradation. Whereas basal levels of autophagy ensure the physiological turnover of old and damaged organelles, the massive accumulation of autophagic vacuoles may represent either an alternative pathway of cell death or an ultimate attempt for cells to survive by adapting to stress. The activation of the autophagic pathway beyond a certain threshold may promote cell death directly, by causing the collapse of cellular functions as a result of cellular atrophy (autophagic, or type II, cell death). Alternatively, autophagy can lead to the execution of apoptotic (type I) or necrotic (type III) cell death programs, presumably via common regulators such as proteins from the Bcl-2 family. On the other hand, limited self-eating can provide cells with metabolic substrates to meet their energetic demands under stressful conditions, such as nutrient deprivation, or favor the selective elimination of damaged (and potentially dangerous) organelles. In these instances, autophagy operates as a pro-survival mechanism. The coordinate regulation of these opposite effects of autophagy relies upon a complex network of signal transducers, most of which also participate in non-autophagic signaling cascades. Thus, autophagy occupies a crucial position within the cell's metabolism, and its modulation may represent an alternative therapeutic strategy in several pathological settings including cancer and neurodegeneration. Here, we present a general outline of autophagy followed by a detailed analysis of organelle-specific autophagic pathways and of their intimate connections with cell death.
Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint (1998)

Mad2 is a component of the spindle checkpoint, which delays the onset of anaphase until all chromosomes are attached to the spindle. Mad2 formed a complex with Slp1, a WD (tryptophan-aspartic acid)-repeat protein essential for the onset of anaphase. When the physical interaction between the two proteins was disrupted, the spindle checkpoint was no longer functional. Post-anaphase events such as chromosome decondensation and the next round of DNA replication were not delayed even when the spindle assembly was incomplete. This relief of dependence appears to be a result of deregulation of ubiquitin-dependent proteolysis mediated by the anaphase-promoting complex.
Chitinase production by Myrothecium verrucaria and its significance for fungal mycelia degradation. (1989)

Myrothecium verrucaria produced high levels of chitinases in a medium containing chitin used as a sole carbon source. Adding 0.03% urea increased the enzyme yield 4-fold in 7 days compared to the control. Adding oxgall (0.1%) to the growth medium gave the maximum activity (acid-swollen chitin-degrading activity, 2.0IU/ml) in 7 days. The biochemical characterization of the chitinase revealed its broader temperature (25-55°C) and pH (4.0-6.5) profiles of activity which showed its potential application in fungal mycelia degradation. Compared to commercial lytic enzyme preparations (NovoZym 234 and Onozuka R-10), M, verrucaria culture filtrate had 5-6 times more chitinase activity. And this produced significantly higher levels of N-acetyl-D-glucosamine from the fungal mycelia preparations under study.
The<i>Arabidopsis HY5</i>gene encodes a bZIP protein that regulates stimulus-induced development of root and hypocotyl (1997)

Plant developmental processes are controlled by both endogenous programs and environmental stimuli. As a photomorphogenetic mutant, hy5 of Arabidopsis has been isolated and characterized. Our detailed characterization has revealed that the mutant is deficient in a variety of stimulus responses, including gravitropic response and waving growth of roots, as well as light-dependent hypocotyl elongation. In the roots and hypocotyl, the hy5 mutation also affects greening and specific cell proliferation such as lateral root formation and secondary thickening. Those phenotypes indicate that the HY5 gene is responsible for the regulation of fundamental developmental processes of the plant cell: cell elongation, cell proliferation, and chloroplast development. Molecular cloning of the HY5 gene using a T-DNA-tagged mutant has revealed that the gene encodes a protein with a bZIP motif, one of the motifs found in transcriptional regulators. Nuclear localization of the HY5 protein strongly suggests that the HY5 gene modulates the signal transduction pathways under the HY5-related development by controlling expression of genes downstream of these pathways.
An Image Composition Technique using Water-wave Image Analysis (2008)

In this study, we want to composite the source image and the target image when the environment includes water surface in the target image such as lake, sea, etc. The water surface is different from other common environment. On the water surface, the object must be reflected or refract and sometimes is deformed by the wave of water. In order to composite the object in the source image onto the water image, we analyze the water surface of the target image and let the object be synthesized realistically based on the wave of water. Our composite process consists of three steps. First. we use Shape-from-Shading technique to extract the normal vector of the water surface in the target image. Next, the source image is deformed according to the normal vector map. Finally, we composite the deformed object onto the target image
New Type LVDT Position Detector (1988)

We describe in this paper two kinds of new type position detector which can be attached to the linear motor for one or two dimensional precise positioning. These detectors give the position signal by the principle of linear variable differential transformer (LVDT), but have quite different structure from the usual type .