gebhart/patrepeval huggingface dataset:
Designing Nonsaccharide, Allosteric Activators of Antithrombin for Accelerated Inhibition of Factor Xa (2011)

Antithrombin is a key regulator of coagulation and prime target of heparins, clinically used anticoagulants. Heparins induce a two-step conformational activation of antithrombin, a process that has remained challenging to target with molecules devoid of the antithrombin-binding pentasaccharide DEFGH. Computational screening of a focused library led to the design of two tetra-sulfated N-arylacyl tetrahydroisoquinoline variants as potential nonsaccharide activators of antithrombin. A high yielding synthetic scheme based on Horner-Wadsworth-Emmons or Pictet-Spengler reactions was developed to facilitate the functionalization of the tetrahydoisoquinoline ring, which upon further amidation, deprotection, and sulfation gave the targeted nonsaccharide activators. Spectrofluorometric measurement of affinity displayed antithrombin binding affinities in the low to high micromolar range at pH 6.0, I 0.05, 25 °C. Measurement of second-order rate constants of antithrombin inhibition of factor Xa in the presence and absence of the designed activators showed antithrombin activation in the range of 8-80-fold in the pH 6.0 buffer. This work puts forward 20c, a novel tetra-sulfated N-arylacyl tetrahydroisoquinoline-based molecule, that activates AT only 3.8-fold less than that achieved with DEFGH, suggesting a strong possibility of rationally designing sulfated organic molecules as clinically relevant AT activators.
The simulation of hydrolytic polymerization of ϵ‐caprolactam in various reactors (1982)

Abstract The concrete simulation models dealing with the kinetic behavior of the hydrolytic polymerization of ϵ‐caprolactam (CL) in various polymerization reactors used in the industry were described, and the method for their numerical solutions was presented. The characteristic data of the polymerization such as the concentrations of CL, end group, water, ϵ‐aminocaproic acid, cyclic dimer, and the hot‐water‐soluble component, conversion, number average, and weight average molecular weights, and solution and melt viscosities can be calculated at every stage of the polymerization reaction, at every part of the reactors, and/or at the outlet of the reactors. The calculated values based upon the models were found to be quite compatible with the observed values for the reactors. The applicability of the technique was well confirmed for the quality control, process control, modification of existing plants, and development of new chemical process plants.
An Oxidoreductase Is Involved in Cercosporin Degradation by the Bacterium <i>Xanthomonas campestris</i> pv. zinniae (2006)

The polyketide toxin cercosporin plays a key role in pathogenesis by fungal species of the genus Cercospora. The bacterium Xanthomonas campestris pv. zinniae is able to rapidly degrade this toxin. Growth of X. campestris pv. zinniae strains in cercosporin-containing medium leads to the breakdown of cercosporin and to the formation of xanosporic acid, a nontoxic breakdown product. Five non-cercosporin-degrading mutants of a strain that rapidly degrades cercosporin (XCZ-3) were generated by ethyl methanesulfonate mutagenesis and were then transformed with a genomic library from the wild-type strain. All five mutants were complemented with the same genomic clone, which encoded a putative transcriptional regulator and an oxidoreductase. Simultaneous expression of these two genes was necessary to complement the mutant phenotype. Sequence analysis of the mutants showed that all five mutants had point mutations in the oxidoreductase gene and no mutations in the regulator. Quantitative reverse transcription-PCR (RT-PCR) showed that the expression of both of these genes in the wild-type strain is upregulated after exposure to cercosporin. Both the oxidoreductase and transcriptional regulator genes were transformed into three non-cercosporin-degrading bacteria to determine if they are sufficient for cercosporin degradation. Quantitative RT-PCR analysis confirmed that the oxidoreductase was expressed in all transconjugants. However, none of the transconjugants were able to degrade cercosporin, suggesting that additional factors are required for cercosporin degradation. Further study of cercosporin degradation in X. campestris pv. zinniae may allow for the engineering of Cercospora-resistant plants by using a suite of genes.
ICI and Compensation Algorithm against Frequency Offset and Phase Noise in SC-FDMA System with Comb Type Pilot (2010)

SC-FDMA(Single Carrier-Frequency Division Multiple Access)는 DFT(Discrete Fourier Transform)-spreading 방식을 사용하여 OFDM(Orthogonal Frequency Division Multiplexing) 신호의 PAPR(Peak to Average Power Ratio) 저감하여 전력효율을 향상시키는 방식이다. 그러나, PAPR을 저감하기 위하여 블록 type 파일럿을 사용하기 때문에 이동 환경에 따른 도플러 주파수와 송수신기 사이의 주파수 불일치로 인한 주파수 옵셋과 시간 도메인에서의 위상 잡음으로 주파수 도메인에서 ICI(Inter Channel Interference)가 발생하여 SC-FDMA 시스템의 성능은 저감된다. 그러므로 이동 환경 및 위상 잡음을 제거하기 위하여 comb type 파일럿을 고려하고, 이에 대한 PAPR을 감소시키기 위하여 SLM(Selective Mapping) 기법을 사용하며, 효과적인 채널 추정 및 ICI 제거를 위한 기법을 제안한다. 그러므로 기존 블록 type에 비해 comb type을 사용함으로써 이동 수신 성능이 향상될 수 있으며 효과적으로 주파수 옵셋 및 위상 잡음을 효과적으로 제거 가능함을 보인다. SC-FDMA system uses DFT-spreading method for reducing the PAPR of OFDM signal, which improves the power efficiency. Block type pilot is used in SC-FDMA system. However, there are ICI due to the inevitable phase noise and frequency offset that can be generated from the Doppler frequency and inaccuracy between the transceiver oscillators. This ICI definitely degrades the BER performance. To overcome this problem and estimate the channel efficiently, we like to propose ICI compensation algorithm for the SC-FDMA system with comb type pilot. SLM method is additionally included for the PAPR reduction when pilot is assigned in comb type. Finally, it is confirmed that the ICI due to the phase noise and frequency offset is efficiently compensated by the suggested algorithm.
KVS – INFLIBNET In‐Service Training Programme for School Librarians on Library Automation, Networking and E‐Resources Management Organised by INFLIBNET Centre (2004)

Reports on a training programme – KVS ‐ INFLIBNET ‐ an in‐service training programme for school librarians on library automation, networking and e‐resources management. The course was of three weeks duration designed for kendriya vidyalaya school library professionals and held in mid 2004.
Polyvinyl Alcohol Based Membrane as Separator for Alkaline Water Electrolyzer (2011)

Alkaline water electrolyzer employs nickel based electrodes and asbestos cloth diaphragm. Asbestos is considered as carcinogenic. In order to limit the usage of an asbestos diaphragm, a separator membrane was synthesized from polyvinyl alcohol, glutaraldehyde, N,N,N′N′-Tetramethyl hexane-1,6 diamine, and titanium dioxide. The role of N,N,N′N′-Tetramethyl hexane-1,6 diamine is to improve the dimensional stability of the membrane. The fabricated membranes were characterized by FT-IR, TGA, DSC, and SEM techniques. These fabricated membranes effectively improved the production of hydrogen, more so than the conventional asbestos diaphragm. A current density of 0.38 A/cm2 was achieved when operating the cell with 5 wt% KOH at 30°C at 2 V. Polyvinyl alcohol composite membranes, besides being cheap, showed good electrochemical performance at ambient temperature and pressure than most commercial separator membranes. This comparison gives some insight as to future separator membrane design objectives.
Detection of nuclear magnetic resonance in the microtesla range using a high T<sub>c</sub>dc-SQUID (2012)

We have detected the ultra-low field nuclear magnetic resonance signal from water samples using a high-Tc dc-SQUID sensor. The measurements were carried out in a homemade magnetically shielded room. Resonance spectra of 1H from tap water and other substance samples were obtained in the field range from 7-110μT corresponding to resonance frequency 300-4.68kHz. Two kind of experimental systems were built, the first one is a directly coupled system, its signal to noise ratio in a single-shot measurement is around 4 for about 15 ml water. The second one used a Cu coil to transfer the flux to the SQUID sensor. Signal to noise ratio was improved to about 20 in a single-shot measurement for 5ml water, which benefits from the improvement of coupling efficiency. The effect of residual gradient in the magnetically shielded room was also investigated. J-coupling of 2,2,2-Trifluoroethyl alcohol was measured, the peaks are consistent with high field results.
Using information visualization for accessing learning object repositories (2004)

Learning objects are entities that may be used for learning, education or training. Nowadays they are often stored in learning object repositories (LORs), such as the Ariadne Knowledge Pool System (KPS) as stated in E. Duval et al. (2001), Merlot and EdNa. Typically users can search for learning objects in those LORs by filling out an electronic form that enables them to compose Boolean combinations of search criteria. More research is needed on novel access paradigms to enable more effective and flexible access to these repositories. We investigate how we can use information visualization techniques for this purpose. We discuss the use of three existing information visualization techniques that we applied to the ARIADNE Knowledge Pool System (KPS).
Clinical Efficacy of Human Papillomavirus DNA Detection in Urine from Patients with Various Cervical Lesions (2007)

A considerable number of adult Korean women avoid a Pap smear due to fear and discomfort of the pelvic examination. A reliable but noninvasive and comfortable screening method would considerably increase the participation rate. To evaluate the clinical efficacy of urine-based human papillomavirus (HPV) detection by oligonucleotide microarray, the results of HPV test from matched cervical swab specimens were compared. HPV DNA was detected in 70 of 100 cervical samples. HPV 16 was the most prevalent type (38/70), followed by types 18, 58, 52, 33, 35, 31, and 51. HPV DNA was identified in 47 of 90 urine samples. HPV 16 was the most prevalent type (30/45), followed by types 18, 52, 35, 51, 58, 33, and 56. The HPV detection rates of the cervical swabs increased in accordance with the severity of the cytologic and histologic diagnosis. The type specific agreement of HPV DNA tests between cervical swabs and urine was good in HPV 16 (kappa index=0.64 [95% CI: 0.50-0.79]), 18, 52, and 58 and fair in HPV 33 and 35. We propose that a urine HPV test is a valuable adjunctive method for a conventional Pap smear and can be used in population screening for cervical cancer in countries where it is difficult to obtain colposcopic specimens for cultural or religious reasons.
PEB1, the major cell-binding factor of Campylobacter jejuni, is a homolog of the binding component in gram-negative nutrient transport systems. (1993)

The protein PEB1 (28 kDa) is a common antigen and a major cell adherence molecule of Campylobacter jejuni and Campylobacter coli. We created a bank of chromosomal DNA fragments of C. jejuni strain 81-176 using lambda gt11. Screening this bank in Escherichia coli Y1090 cells with antibody raised against purified PEB1 enabled us to isolate and to purify a clone with a 2.6-kilobase insert expressing an immunoreactive protein of 28 kDa. DNA sequencing revealed that the insert contains three complete and two partial open reading frames (ORFs), designated 5' to 3' as ORFs A-E. The peb1A gene (ORF D) contains 780 bases encoding a 259-residue polypeptide having a calculated molecular mass of 28,181 Da. The peptide sequence starting at residue 27 matches that determined from aminoterminal sequencing of mature PEB1 from C. jejuni. The first 26 residues contain typical signal peptidase I and II cleavage sites. The deduced amino acid composition and pI of the recombinant mature protein are similar to those determined for purified PEB1. Gene bank searches indicated significant overall homology of peb1A and ORF C with operons for amino acid transport systems in other Gram-negative organisms. peb1A is homologous to the binding components of systems such as glnH (27.8%) and hisJ (28.9%), whereas ORF C has nearly 50% identity to glnQ and hisP. Thus, PEB1 could be involved both in binding to intestinal cells and in amino acid transport.
Structure and regulation of eukaryotic initiation factor eIF-2. Sequence of the site in the alpha subunit phosphorylated by the haem-controlled repressor and by the double-stranded RNA-activated inhibitor (1987)

Eukaryotic protein synthesis initiation factor 2 (eIF-2) can be phosphorylated on its alpha subunit by two well-characterised protein kinases, termed the haem-controlled repressor (HCR) and the double-stranded RNA-activated inhibitor (dsI). Phosphorylation of eIF-2 by these kinases is thought to be important in the regulation of peptide-chain initiation. We report the location of the serine residue in the alpha subunit, which is phosphorylated by both these enzymes. Limited tryptic digestion and subsequent cyanogen bromide treatment of rat liver eIF-2 phosphorylated by HCR yielded one major phosphopeptide. This peptide had the sequence Ile-Leu-Leu-Ser-Glu-Leu-Ser(P)-Arg-Arg. The same major phosphopeptide was obtained from rabbit reticulocyte eIF-2 phosphorylated by HCR or dsI as judged by its behaviour on two-dimensional mapping and reverse-phase chromatography. In all cases the phosphorylated residue was found to be serine-7, and not serine-4, of the above sequence as determined from sequence analysis and by subdigestion of the peptide with Staphylococcus aureus V8 proteinase.
A method of generating global view texture images in 3D face modeling (2010)

Construction of 3D special face model with 2D face photographs has become the focus of study on 3D face modeling, in which generated texture will affect directly the sense of reality of the 3D face model. Based on the details of texture mapping and image stitching, a method of generating global view texture images in 3D face modeling is proposed in this paper. Firstly, it obtains overlap regions by means of column feature matching and confirms the regions according to the grey values, and then stitches the images accurately; Secondly, it blends the texture with weighted smoothing algorithm to eliminate image mosaic gaps; Finally, it tries the classic Laplacian pyramid method to get a new global-view face texture image, which makes the texture image more realistic and natural.
A genetic algorithm for unmanned aerial vehicle routing (2005)

Genetic Algorithms (GAs) can efficiently produce high quality results for hard combinatorial real world problems such as the Vehicle Routing Problem (VRP). Genetic Vehicle Representation (GVR), a recent approach to solving instances of the VRP with a GA, produces competitive or superior results to the standard benchmark problems. This work extends GVR research by presenting a more precise mathematical model of GVR than in previous works and a thorough comparison of GVR to Path Based Representation approaches. A suite of metrics that measures GVR's efficiency and effectiveness provides an adequate characterization of the jagged search landscape. A new variation of a crossover operator is introduced. A previously unmentioned insight about the convergence rate of the search is also noted that is especially important to the application of a priori and dynamic routing for swarms of Unmanned Aerial Vehicles (UAVs). Results indicate that the search is robust, and it exponentially drives toward high quality solutions in relatively short time. Consequently, a GA with GVR encoding is capable of providing a state-of-the-art engine for a UAV routing system or related application.
Myrc (1928)

Myrc Get access Arthur W. Marks Arthur W. Marks Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CLV, Issue aug11, 11 August 1928, Page 100, https://doi.org/10.1093/nq/CLV.aug11.100b Published: 11 August 1928
PEG-Assisted DNA Solubilization in Organic Solvents for Preparing Cytosol Specifically Degradable PEG/DNA Nanogels (2006)

DNA was dissolved in selected organic solvents in the presence of poly(ethylene glycol) (PEG). Nanoscale PEG/DNA complex (approximately 100 nm) was produced in dimethylsulfoxide (DMSO) phase. Using a thiol-functionalized six-arm branched PEG for DNA solubilization, the PEG/DNA nanocomplex was cross-linked through the formation of disulfide linkages between the thiol groups, resulting in the production of stable PEG/DNA nanogels in aqueous solution. DNA release from the nanogels could be modulated by changing the concentration of an external reducing agent. The released plasmid DNA from the nanogels maintained intact structural integrity and exhibited appreciable gene transfection efficiency. The PEG/DNA nanogels could be potentially applied for gene therapy including DNA vaccination.
Binary nucleation of ethanol and water (1990)

The authors have used a fast expansion cloud chamber to measure binary homogeneous nucleation rates in several ethanol–water mixtures as a function of temperature, ethanol and water activities and nucleation rate. Data (ethanol and water activities) are presented for a range in nucleation rate from 103 to 105 drops/cm3 s from 263 to 293 K for mixtures having mole ratios (ethanol/water) of 10, 4, 0.1, 0.01, and 0.001. A comparison of the extensive data set to other data in the literature shows good agreement. We find current theory, as expected, is unable to accurately predict the data at low ethanol concentrations.
Fluorous mixture synthesis (FMS) of enantiomers, diastereomers, and compound libraries (2004)

Fluorous mixture synthesis (FMS) is a newly developed highly-efficient solution-phase technology. A set of substrates attached to homologous fluorous tags is mixed and taken through a sequence of organic reactions. The final mixtures are demixed by fluorous HPLC and detagged to give individually pure final products. Applications of FMS for the preparation of 2 enantiomers of pyridovericin, 16 diastereomers of murisolin, and a 560-member mappicine library are highlighted in this article.
Targeted disruption of NF-κB1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling (2009)

NF-kappaB-mediated proinflammatory response to cigarette smoke (CS) plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). The heterodimer of RelA/p65-p50 (subunits of NF-kappaB) is involved in transactivation of NF-kappaB-dependent genes, but interestingly p50 has no transactivation domain. The endogenous role of p50 subunit, particularly in regulation of CS-mediated inflammation in vivo, is not known. We therefore hypothesized that p50 subunit plays a regulatory role on RelA/p65, and genetic ablation of p50 (p50(-/-)) leads to increased lung inflammation and lung destruction in response to CS exposure in mouse. To test this hypothesis, p50-knockout and wild-type (WT) mice were exposed to CS for 3 days to 6 mo, and inflammatory responses as well as air space enlargement were assessed. Lungs of p50-deficient mice showed augmented proinflammatory response to acute and chronic CS exposures as evidenced by increased inflammatory cell influx and proinflammatory mediators release such as monocyte chemoattractant protein-1 (MCP-1) and interferon-inducible protein-10 (IP-10) compared with WT mice. IKK2 inhibitor (IMD-0354), which reduces the nuclear translocation of RelA/p65, attenuated CS-mediated neutrophil influx in bronchoalveolar lavage fluid and cytokine (MCP-1 and IP-10) levels in lungs of WT but not in p50-deficient mice. Importantly, p50 deficiency resulted in increased phosphorylation (Ser276 and Ser536), acetylation (Lys310), and DNA binding activity of RelA/p65 in mouse lung, associated with increased chromatin remodeling evidenced by specific phosphoacetylation of histone H3 (Ser10/Lys9) and acetylation of H4 (Lys12) in response to CS exposure. Surprisingly, p50-null mice showed spontaneous air space enlargement, which was further increased after CS exposure compared with WT mice. Thus our data showed that p50 endogenously regulates the activity of RelA/p65 by decreasing its phosphoacetylation and DNA binding activity and specific histone modifications and that genetic ablation of p50 leads to air space enlargement in mouse.
Einleitung: Verstand und Vernunft. Möglichkeit und Wirklichkeit. Antinomik der Vernunft. Erkenntnis in der Erscheinung. Determination und Reflexion (1976)

Einleitung: Verstand und Vernunft. Möglichkeit und Wirklichkeit. Antinomik der Vernunft. Erkenntnis in der Erscheinung. Determination und Reflexion was published in Reflexion und Determination on page 1.
Near-infrared femtosecond photoionization/dissociation of cyclic aromatic hydrocarbons (1995)

Pulses of 780 nm light of duration 170 fs and power densities up to 3.8×1013 W cm−2 are used to study the photoionization/dissociation processes in the series of gas phase, cyclic aromatic hydrocarbons including benzene, naphthalene, phenanthrene, and anthracene. The near-infrared ionization process leads to the production of intact molecular ions for all of the molecules studied. Measurements of the ion intensity as a function of laser fluence revealed the order of the ultrafast ionization process to be 8.0±0.1 for anthracene, 6.9±0.1 for phenanthrene, 8.5±0.1 for naphthalene, and 8.1±0.1 for benzene. The relative femtosecond photoionization cross section decreased from 1.0 for anthracene to 0.2 for phenanthrene to 0.1 for naphthalene to ∼0.005 for benzene. The relative order and cross section of the femtosecond ionization processes suggest that a field ionization mechanism is operative.
Broadband public network and switch architecture (1991)

The authors present a view of public network and switch architecture evolution to broadband capabilities, driven by the applications evolutions and built on a synchronous fiber transmission infrastructure such as SONET (synchronous optical network). The scenario is based on the partitioning of broadband network functions between synchronous fiber transmission systems and cell-based transport. The first stage of evolution incorporates frame-based switching to support increasing data traffic for LAN (local area network) interconnections. Cell-based technology appears first in the form of point-to-point high-speed data trunks and then as switched high-speed access. Centralized cell switching will provide interconnect between cell-based trunks and shared access lines. Remote cell multipliers will provide traffic concentration when the number of customers further increases. Since cell transport will first be introduced in the network as an extension of frame transport to higher speed, interworking between cells and frames will be necessary.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>