gebhart/patrepeval huggingface dataset:
Identification and Biological Activity of Synthetic Macrophage Inducible C-Type Lectin Ligands (2018)

The Macrophage Inducible C-Type Lectin (Mincle) is a pattern recognition receptor able to recognise both damage-associated and pathogen-associated molecular patterns, and in this respect, there has been much interest in determining the scope of ligands that bind Mincle and how structural modifications to these ligands influence ensuing immune responses. In this review we will present Mincle ligands of known chemical structure, with a focus on ligands that have been synthetically prepared, such as trehalose glycolipids, glycerol-based ligands, and 6-acylated glucose and mannose derivatives. The ability of the different classes of ligands to influence the innate, and consequently, the adaptive, immune response will be described, and where appropriate, structure-activity relationships within each class of Mincle ligands will be presented.
Homogeneity in Pattern of Decline of β-Cell Function in IDDM: Prospective study of 204 consecutive cases followed for 7.4 yr (1992)

No major heterogeneity exists in the pattern of decline of beta-cell function in IDDM, although small differences in pattern could be identified in both sexes, in different age-groups, and in relation to achieving insulin-free remission.
From CT to NURBS: Contour Fitting with B-spline Curves (2010)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
Evaluation for Safety of Antioxidant Chemopreventive Agents (2005)

Antioxidants are considered as the most promising chemopreventive agents against various human cancers. However, some antioxidants play paradoxical roles, acting as "double-edged sword." A primary property of effective and acceptable chemopreventive agents should be freedom from toxic effects in healthy population. Miscarriage of the intervention by beta-carotene made us realize the necessity for evaluation of safety before recommending use of antioxidant supplements for chemoprevention. We have evaluated the safety of antioxidants on the basis of reactivity with DNA. Our results revealed that phytic acid, luteolin, and retinoic acid did not cause DNA damage under the experimental condition. Furthermore, phytic acid inhibited the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine, an indicator of oxidative DNA damage, in cultured cells treated with a H(2)O(2)-generating system. Thus, it is expected that these chemopreventive agents can safely protect humans against cancer. On the other hand, some chemopreventive agents with prooxidant properties (alpha-tocopherol, quercetin, catechins, isothiocyanates, N-acetylcysteine) caused DNA damage via generation of reactive oxygen species in the presence of metal ions and endogenous reductants under some circumstances. Furthermore, other chemopreventive agents (beta-carotene, genistein, daidzein, propyl gallate, curcumin) exerted prooxidant properties after metabolic activation. Therefore, further studies on safety should be required when antioxidants are used for cancer prevention.
Topological optimization of computer networks (1972)

Modeling, analysis, and design problems and methodologies for centralized and distributed computer-communication networks are discussed. The basic problem is to specify the location and capacity of each communication link within the network. The design objective is to provide a low-cost network which satisfies constraints on response time, throughput, reliability, and other parameters. Fundamental network models for queuing and reliability analysis are described, as are basic properties of various network structures. A number of approaches to the topological design problem are presented; areas where further research is needed are indicated; possible approaches to several unsolved problems are suggested.
Sub-Spectrogram Segmentation for Environmental Sound Classification via Convolutional Recurrent Neural Network and Score Level Fusion (2019)

Environmental Sound Classification (ESC) is an important and challenging problem, and feature representation is a critical and even decisive factor in ESC. Feature representation ability directly affects the accuracy of sound classification. Therefore, the ESC performance is heavily dependent on the effectiveness of representative features extracted from the environmental sounds. In this paper, we propose a subspectrogram segmentation based ESC classification framework. In addition, we adopt the proposed Convolutional Recurrent Neural Network (CRNN) and score level fusion to jointly improve the classification accuracy. Extensive truncation schemes are evaluated to find the optimal number and the corresponding band ranges of sub-spectrograms. Based on the numerical experiments, the proposed framework can achieve 81.9% ESC classification accuracy on the public dataset ESC-50, which provides 9.1% accuracy improvement over traditional baseline schemes.
Improving performance of tensor-based context-aware recommenders using Bias Tensor Factorization with context feature auto-encoding (2017)

In this paper, we focus on the problem of context-aware recommendation using tensor factorization. Traditional tensor-based models in context-aware recommendation scenario only consider user-item-context interactions. In this paper, we argue that rating can't be totally explained by the interactions and the rating also influenced by the combined impact of overall mean, user bias, item bias and context bias. Based on this hypothesis, we propose a novel context-aware recommendation model named Bias Tensor Factorization, which take all this factors into account. Additionally, traditional context-aware recommenders with tensor factorization still have three main drawbacks: (1) the model complexity of those models increase exponentially with the number of context features, (2) those models can only handle context features with categorical values and (3) the models fail to select effective features from available context features. To address those problems, we propose a context features auto-encoding algorithm based on regression tree which can both handle numerical features and select effective features. Then we integrate this algorithm with Bias Tensor Factorization. Experiments on a real world contextual dataset and Movielens show that our proposed algorithms outperform the state-of-art context-aware recommendation algorithms, namely tensor factorization and factorization machine.
PR‐924, a selective inhibitor of the immunoproteasome subunit LMP‐7, blocks multiple myeloma cell growth both <i>in vitro</i> and <i>in vivo</i> (2010)

PR-924 is an LMP-7-selective tripeptide epoxyketone proteasome inhibitor that covalently modifies proteasomal N-terminal threonine active sites. In the present study, we show that PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cell lines and primary patient MM cells, without significantly affecting normal peripheral blood mononuclear cells. PR-924-induced apoptosis in MM cells is associated with activation of caspase-3, caspase-8, caspase-9, BID, PARP and cytochrome-c release. In vivo administration of PR-924 inhibits tumour growth in human plasmacytoma xenografts. Results from SCID-hu model show a significant reduction in the shIL-6R levels in mice treated with PR-924 versus vehicle-control. PR-924 treatment was well tolerated as evidenced by the lack of weight loss. Importantly, treatment of tumour-bearing mice with PR-924, but not vehicle alone, prolonged survival. Our preclinical findings therefore validate immunoproteasome LMP-7 subunit as a novel therapeutic target in MM.
Functionalising wood by nanosol application (2008)

This report describes ways in which the properties of wood might be improved by application of silica and other inorganic nanosols. Topics covered are: the synthesis and modification of inorganic nanosols, and methods of applying them to wood to improve its mechanical properties; the use of modified silica sols to realise flame retardant, water repellent and antimicrobial properties; recent nanosol applications for protecting ThermoWood, for restoring and preserving wooden cultural artefacts, and as auxiliaries for improving commercial wood lacquers.
HEALTH FUNCTION AND UTILIZATION OF COLOSTRUMS (2009)

Colostrums is the secretion of milk by healthy cows within 1 week after delivery.It is not only rich in nutrients,but also contain a wide range of immune factors and growth factors etc active ingredients.It has enhanced resistance and immunity,improve gastrointestinal function,and promote growth and development and increase IQ,eliminate fatigue,aging,enhance physique,and raise campaign performance,regulation of blood sugar,and other health functions.It is important raw materials of functional,food has become a promising market.
Haptoglobin: a major susceptibility gene for diabetic cardiovascular disease. (2004)

Haptoglobin polymorphism Haptoglobin is a serum protein for which there are two common alleles in humans, denoted 1 and 2 [1]. The genotype of an individual may therefore be described as being Hp 1-1 (homozygous for the 1 allele), Hp 2-2 (homozygous for the 2 allele), or Hp 2-1 (the heterozygote). The haptoglobin gene locus on chromosome 16q22 has 5 exons encoding the 1 allele or 7 exons encoding the 2 allele [2]. The 2 allele appears to have been generated from the 1 allele by an intragenic duplication event of exons 3 and 4. Hp typing of over 100,000 individuals over the past 35 years has shown considerable geographic and ethnic variation in the frequencies of the two alleles [2]. In Israel, the two alleles are in a balanced polymorphism with approximately 30% of the alleles being type 1 and 70% type 2, thus 9% of the Israeli population is Hp 1-1, 49% is Hp 2-2 and 42% is Hp 2-1 [2]. This allele frequency distribution is quite similar to that found in Europe and the United States. The distribution of these two alleles in individuals with diabetes is not different to that in the general population [3].
A cyanogen bromide fragment of β-galactosidase from Escherichia coli with α-donor activity in complementation of the enzyme from mutant M15 (1976)

Aminoethylated beta-galactosidase from Escherichia coli was cleaved by CNBr. The fragment C4a was purified by gel filtration and ion-exchange chromatography. The molecular weight of the fragment C4a was determined to be 9000 +/- 600. The N-terminal amino acid was found to be isoleucine. Qualitative examination of homogeneity was carried out by disc-gel electrophoresis. The fragment C4a was shown to be active as an alpha donor in complementation of beta-galactosidase activity in vitro with E. coli mutant M15, which has a deletion in the alpha region of the z gene. The molecular weights of complementable fractions from mutant M15 were found to be 123 000 +/- 2500 and 507 000 +/- 11 000, and of the complemented enzyme 522 500 +/- 11 400.
Text Segmentation with Topic Models (2012)

This article presents a general method to use information retrieved from the Latent Dirichlet Allocation (LDA) topic model for Text Segmentation: Using topic assignments instead of words in two well-known Text Segmentation algorithms, namely TextTiling and C99, leads to significant improvements. Further, we introduce our own algorithm called TopicTiling, which is a simplified version of TextTiling In our study, we evaluate and optimize parameters of LDA and TopicTiling. A further contribution to improve the segmentation accuracy is obtained through stabilizing topic assignments by using information from all LDA inference iterations. Finally, we show that TopicTiling outperforms previous Text Segmentation algorithms on two widely used datasets, while being computationally less expensive than other algorithms.
Synthesis, Structural Characterization and Luminescence Studies of Di‐ and Trinuclear Gold(I) Alkynyl‐phosphine Complexes (2010)

Abstract Reactions of the polymer {Au I C 2 Ph} n with polyphosphine ligands [1,4‐bis(2‐diphenylphosphino‐1H‐imidazol‐1‐yl)‐benzene (dpib), 1,3,5‐tris(4‐diphenylphosphinophenyl)benzene (tppb), 2,2′‐bis(diphenylphosphanyl)‐4,4′‐bipyridine (dpbp), and 3,6‐bis(diphenylphosphanyl)pyridazine (dppz)] afforded four gold(I) alkynyl‐polyphosphine complexes [{AuC 2 Ph} 2 (μ‐dpib)] ( 1 ), [{AuC 2 Ph} 3 (μ 3 ‐tppb)] ( 2 ), [{AuC 2 Ph} 2 (μ‐dpbp)] ( 3 ), and [{AuC 2 Ph} 2 (μ‐dppz)] ( 4 ) in nearly quantitative yield. The compounds obtained were characterized using elemental analysis, ESI‐MS, X‐ray crystallography, and polynuclear NMR spectroscopy. Intermolecular aurophilic interaction together with π–π and σ–π stacking build up the supramolecular 3D network of complex 3 , whereas none of these intermolecular bondings were found in the crystal structures of compounds 1 , 2 , and 4 . Complexes 1 – 4 are luminescent both in solution (CH 2 Cl 2 ) and in solid state under laser irradiation (λ ex = 308 nm). In solution, the diphosphine complexes 1 – 4 display dual emission corresponding to ligand centered transitions (λ em = 360–375 nm) along with weaker contribution from MLCT excited states at ca. 490 nm. The long wavelength component of the emission plays a dominant role in the solid state luminescence spectra of complexes 1 , 3 , and 4 (460, 544, 520 nm, respectively) whereas the triphosphine complex 2 shows dual luminescence (372 and 520 nm) with considerable contribution from ligand centered excited state.
Exploitation des Capacités de Radiolocalisation des Transmissions Ultra-Large Bande dans les Réseaux Sans-Fil (2005)

Many recent applications rely on the capability of communication means in delivering precise location information. In this context, the intrinsic properties of the Impulse Radio Ultra Wideband (IR-UWB) technology can be exploited: high multipath resolution, fine temporal precision enabling Time Of Flight (TOF) estimation and synchronization... UWB, which is also adapted to mobile, distributed and infrastructure-less solutions (ad hoc), discloses new fascinating perspectives in terms of networking. Regarding Low Data Rate WPAN applications (e.g. the IEEE 802.15.4a standard, with rates up to 1Mbps), fused communication and location functionalities based on low-cost and low-consumption UWB devices present overwhelming features compared to existing technologies (e.g. Zigbee...). The proposed work addresses the global UWB localization problem in wireless networks. Some general ideas are emphasized, such as the necessity to take into account a prior knowledge related to the UWB physical layer, exploiting multipath diversity or modern network embodiments (from both protocol and topology points of view). At first, the errors that can affect basic radiolocation metrics (Time Of Arrival, Time Difference Of Arrival) are characterized and modelled. These errors can be independent of the physical layer (clock drifts, protocol transactions, etc.) or can result from severe propagation conditions (e.g. Non-Line Of Sight situations). Then, the detection performance of two representative low-complexity UWB receivers (e.g. 1 bit direct sampling) is evaluated under realistic environments. We also recommend the use of original positioning techniques (e.g. distributed maximization of the joint log-likelihood of the range estimates, fingerprinting, mitigation of the deterministic biases induced by single-path refractions) or tracking techniques (e.g. advanced Bayesian filtering) adapted to Non-Line Of Sight situations. Finally, some preliminary experimental results obtained in the lower band ([0.5:1]GHz) are provided and allow us to illustrate some of the discussed points.
Detection Of Formation Damage Associated To Paraffin In Reservoirs Of The Recôncavo Baiano, Brazil (1997)

Abstract This work aims at presenting evidences of paraffination in some reservoirs located in the Recôncavo Baiano, state of Bahia, Brazil, by means of a thermal-chemical method called Nitrogen Generating System or SGN after the original Portuguese expression "Sistema Gerador de Nitrogênio". This method comprises applying the huge amounts of heat and nitrogen gas generated by the reaction between two nitrogen salt-containing aqueous solutions to fluidize the paraffin which becomes then incorporated to the reservoir oil production. In the present work, huge variations were observed for measurements of the melting point, paraffin content, viscosity of the samples, gas chromatography analyses, simulated distillation and wax appearance temperature taken before and after SGN treatment of the reservoirs. It could be seen that the heavy paraffin fraction (C40+) was increased while the light paraffin fraction (C20+ to C40) decreased due to the removal of paraffin deposits from the reservoir next to the perforation.
Inhibition of carbonic anhydrase by parathyroid hormone and cyclic AMP in rat renal cortex in vitro. (1975)

A B S T R A C T It has been demonstrated that para- thyroid hormone (PTH) inhibits the proximal tubular reabsorption of bicarbonate, and increases the urinary excretion of that ion. There is also a qualitative simi- larity between the alterations of the proximal tubular reabsorption of phosphate, sodium, and water after PTH administration and after acetazolamide adminis- tration. These findings suggest that the renal effect of PTH is possibly mediated through the inhibition of carbonic anhydrase in proximal tubules. Therefore, a possible inhibitory effect of PTH on carbonic anhydrase was evaluated in the homogenate of rat renal cortex by an indicator titration method.
Basic Electronics for Scientists (1967)

Direct Current Circuits. Alternating Currents. Diode Circuits. Semiconductor Devices. AC-Circuit Analysis. Transistor Amplifiers. Operational Amplifiers. Oscillators. Digital Electronics. Analog and Digital Measurements. Microprocessors. Microprocessor Circuits. Appendices. Index.
Contents, Vol. 58, 2012 (2012)

and/or infrequently employed drug.
Biomechanical Comparison of Transarticular Facet Screws to Lateral Mass Plates in Two-Level Instrumentations of the Cervical Spine (2005)

This study proves that transarticular facet screws and lateral mass plates are equivalent in two-level instrumentations of the cervical spine. This is the first biomechanical study to test transarticular facet screws in this context.
Electrodynamics of Solids (2002)

The authors of this book present a thorough discussion of the optical properties of solids, with a focus on electron states and their response to electrodynamic fields. A review of the fundamental aspects of the propagation of electromagnetic fields, and their interaction with condensed matter, is given. This is followed by a discussion of the optical properties of metals, semiconductors, and collective states of solids such as superconductors. Theoretical concepts, measurement techniques and experimental results are covered in three interrelated sections. Well-established, mature fields are discussed (for example, classical metals and semiconductors) together with modern topics at the focus of current interest. The substantial reference list included will also prove to be a valuable resource for those interested in the electronic properties of solids. The book is intended for use by advanced undergraduate and graduate students, and researchers active in the fields of condensed matter physics, materials science and optical engineering.
Die Meigen'schen Typen der sogen. Muscidae acalypterae (Muscaria holometopa) in Paris und Wien (Fortsetzung.) (1902)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Regulation of Torsin ATPases by LAP1 and LULL1 (2013)

TorsinA is a membrane-associated AAA+ (ATPases associated with a variety of cellular activities) ATPase implicated in primary dystonia, an autosomal-dominant movement disorder. We reconstituted TorsinA and its cofactors in vitro and show that TorsinA does not display ATPase activity in isolation; ATP hydrolysis is induced upon association with LAP1 and LULL1, type II transmembrane proteins residing in the nuclear envelope and endoplasmic reticulum. This interaction requires TorsinA to be in the ATP-bound state, and can be attributed to the luminal domains of LAP1 and LULL1. This ATPase activator function controls the activities of other members of the Torsin family in distinct fashion, leading to an acceleration of the hydrolysis step by up to two orders of magnitude. The dystonia-causing mutant of TorsinA is defective in this activation mechanism, suggesting a loss-of-function mechanism for this congenital disorder.
Chemistry of boranes. XXX. Carbonyl derivatives of B10H102- and B12H122- (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of boranes. XXX. Carbonyl derivatives of B10H102- and B12H122-Walter H. Knoth, John C. Sauer, Joseph H. Balthis, Henry Charles. Miller, and Earl L. MuettertiesCite this: J. Am. Chem. Soc. 1967, 89, 19, 4842–4850Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/ja00995a004https://doi.org/10.1021/ja00995a004research-articleACS PublicationsRequest reuse permissionsArticle Views346Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hierarchical storage management in a distributed VOD system (1996)

The article describes the storage management algorithms in the Berkeley Video-on-Demand System, a hierarchical storage management system designed to support transparent access to thousands of hours of video material. Storage management algorithms handle continuous media objects stored on video servers within a hierarchical distributed video-on-demand system. Media objects stored permanently on tertiary storage devices are moved to video servers when needed. Algorithms manage the distributed cache in the video servers and select a video server on which to place a requested object. The object-placement algorithm uses server load, network load, and service-wait times to optimize system performance.
Inhibition of Df-Protease Associated with Allergic Diseases by Polyphenol (1999)

It was reported that Df-protease from house dust mite (Dermatophagoides farinae) catalyzes the activation of the kallikrein-kinin system in human plasma and is closely associated with mite-induced allergy. Therefore, to prevent the release of kinin by Df-protease, the inhibitory activity of polyphenols including catechins and flavonols was tested in vitro and in vivo. Among them, myricetin and epigallocatechin gallate (EGCg) effectively inhibited the amidase activity of Df-protease with K(i) values of 1 x 10(-)(8) and 6 x 10(-)(4) M, respectively. The kinin release in human plasma was extensively inhibited by the addition of EGCg in comparison with myricetin. Enhancement of vascular permeability in guinea pigs caused by Df-protease was markedly suppressed by EGCg.