gebhart/patrepeval huggingface dataset:
[Amyloidosis of the eye combined with other senile pathology]. (1993)

478 eyes of 313 patients aged from 25 to 90 years and older were investigated (postmortem and surgical material was used). Patients had cataracts, glaucoma, diabetes mellitus. The goal of the study was establishing the amyloid nature of the pseudoexfoliative material (PEM) in the anterior part of the eye. The study showed PEM to be a variety of the amyloid-pseudoexfoliative amyloid (PEA) which was found in 66 (14%) eyes. The localisation and morphology of PEA in various parts of the eye are described in detail. PEA may be the only manifestation of the senile eye amyloidosis, but may be combined with insular amyloidosis of the pancreas.
Metal-assisted terpenoid synthesis. I. Regioselective isoprene insertion into an allyl-magnesium bond and the applications to synthesis of natural terpenoids (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal-assisted terpenoid synthesis. I. Regioselective isoprene insertion into an allyl-magnesium bond and the applications to synthesis of natural terpenoidsSusumu Akutagawa and Sei OtsukaCite this: J. Am. Chem. Soc. 1975, 97, 23, 6870–6871Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/ja00856a049https://doi.org/10.1021/ja00856a049research-articleACS PublicationsRequest reuse permissionsArticle Views202Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intralymphatic Dendritic Cell Vaccination Induces Tumor Antigen–Specific, Skin-Homing T Lymphocytes (2006)

The evidence presented here is consistent with immunization studies in animal models and supports the concept that T cells are "imprinted" in peripheral lymph node sites to express specific ligands and chemokine receptors that allow them to migrate to skin. Furthermore, the preferential migration of the T cells to sun-exposed cutaneous sites suggests that inflammation plays a critical role in this migration. These observations suggest that further study of the effects of immunization route and inflammation on T-cell migration in humans is warranted, and could lead to vaccination approaches that would more reliably direct trafficking of activated T cells to diverse sites of metastatic disease.
Mapping Quantitative Trait Loci for Partial Resistance to <i>Phytophthora sojae</i> in a Soybean Interspecific Cross (2010)

Phytophthora root and stem rot of soybean, caused by Phytophthora sojae Kaufmann & Gerdemann, is a serious limitation to soybean [ Glycine max (L.) Merr.] production in the USA. Partial resistance or field resistance to P. sojae in soybean is effective against multiple races of the pathogen and is a form of incomplete resistance. An interspecific recombinant inbred line (RIL) population consisting of 298 individuals derived from the cross of V71–370 by PI407162 was inoculated with the P. sojae isolate C2S1 using the slant board technique in three separate experiments (designated as 2005, 2006a, and 2006b). In each replication, seven day old seedlings from each RIL were inoculated and lesion lengths were recorded 7 d later to assess partial resistance with three replications for the 2005 and 2006a experiments and one replication for the 2006b screening. Interval mapping located a lesion length QTL on each of the molecular linkage groups (MLGs)–J (chrom. 16),‐I (chrom. 20) and–G (chrom. 18) in all three experiments. The lesion length QTL on MLG‐J accounted for 32, 42, and 22% of the phenotypic variation in the 2005, 2006a and 2006b experiments, respectively. Mapped QTL locations in the current study provide breeders with new sources of P. sojae resistance and suggest that new sources may be identified in soybean germplasm.
Librarians' Image and Users' Attitudes to Reference Interviews. (1988)

Discussion des differentes manieres d'ameliorer l'image du bibliothecaire aupres des utilisateurs
Lumber values from computerized simulation of hardwood log sawing (1980)

Computer simulation sawing programs were used to study the sawing of mathematical models of hardwood logs by me live sawing and three 4-sided sawing methods. One of the 4-sided methods simulated "grade sawing" by sawing each successive board from the log face with the highest potential grade. Logs from 10 through 28 inches in diameter were sawn. In addition, a refinement in the live sawing called live rip, in which center-sawn boards are ripped to increase value, was studied. Results generally indicate that all of the 4-sided methods studied gave similar lumber values. Live sawing was better than the 4-sided methods with good logs but inferior for 10-and 12-inch logs with large detective cores. Live sawing followed by ripping produced the highest lumber values in almost all cases.
Sensors and Systems for the Detection of Explosive Devices - An Overview (2012)

Sensors and Systems for the Detection of Explosive Devices - An Overview The paper presents analyses of current research projects connected with explosive material sensors. Sensors are described assigned to X and γ radiation, optical radiation sensors, as well as detectors applied in gas chromatography, electrochemical and chemical sensors. Furthermore, neutron techniques and magnetic resonance devices were analyzed. Special attention was drawn to optoelectronic sensors of explosive devices.
A BCI-based environmental controller for the motion-disabled (2003)

With the development of brain-computer interface (BCI) technology, researchers are now attempting to put current BCI techniques into practical application. This paper presents an environmental controller using a BCI technique based on steady-state visual evoked potential. The system is composed of a stimulator, a digital signal processor, and a trainable infrared remote-controller. The attractive features of this system include noninvasive signal recording, little training requirement, and a high information transfer rate. Our test results have shown that this system can distinguish at least 48 targets and provide a transfer rate up to 68 b/min. The system has been applied to the control of an electric apparatus successfully.
Cosmic Ray Radiography of the Damaged Cores of the Fukushima Reactors (2012)

The passage of muons through matter is dominated by the Coulomb interaction with electrons and nuclei. The interaction with the electrons leads to continuous energy loss and stopping of the muons. The interaction with nuclei leads to angle "diffusion." Two muon-imaging methods that use flux attenuation and multiple Coulomb scattering of cosmic-ray muons are being studied as tools for diagnosing the damaged cores of the Fukushima reactors. Here, we compare these two methods. We conclude that the scattering method can provide detailed information about the core. Attenuation has low contrast and little sensitivity to the core.
Catalytic Dehydrogenation of Representative Hydrocarbons (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic Dehydrogenation of Representative HydrocarbonsAlex G. Oblad, Robert F. Marschner, and Llewellyn HeardCite this: J. Am. Chem. Soc. 1940, 62, 8, 2066–2069Publication Date (Print):August 1, 1940Publication History Published online1 May 2002Published inissue 1 August 1940https://pubs.acs.org/doi/10.1021/ja01865a044https://doi.org/10.1021/ja01865a044research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Short-pulse laser beam interactions with biocompatible polymer materials and tissue</title> (1996)

Pulsed laser beams, of very short duration, appear to be very promising tools for polymer surface processing. Recently we have studied the interaction of picosecond and femtosecond laser radiation in the visible region of the spectrum with synthetic polymer films and we have compared these studies with our similar studies with nanosecond duration laser radiation. Biocompatible polymers have been extensively used for sutures, vascular grafts or bone and other hard tissue replacements. The use of surgical lasers for intervention on biocompatible material - tissue interfaces has attracted a great deal of interest, as both the high intensity, short pulse duration lasers and the prosthetic biomaterials are in increasing use. Our recent ablation studies, using ultrashort laser pulses, of biocompatible materials, are described in this article. Lasers were introduced in medical research in the early sixties but the laser beam ability to remove efficiently and safely soft or hard tissue, the lateral thermal damage and the final surface characteristics are still under investigation. In the past few years, by virtue of their water or water and hydroxyapatite content respectively, exhibit strong absorption restricting residual thermal damage to a relatively small zone. Recently we have investigated the interaction of short pulse laser radiation of picosecond and femtosecond duration with soft and hard tissue, as this unexplored field is expected to be a potential alternative in powerful laser processing of biomedical structures. The experimental results obtained, including ablation rates, ablation wavelength dependence, pulse duration dependence, fluence dependence, etc. are presented. These results are discussed according to simple theoretical models of laser energy absorption and the possible mechanisms of ultrashort pulse laser ablation, which in some cases involves multiphoton photodissociation processes. Finally, the design characteristics of the lasers employed in our experiments, are stated briefly.
基于全程实习临床实践教学模式的研究与实践* (2015)

临床教学医院，承担着高等医学院校的医学生的临床教学任务，传统的“小二段”教学模式即前期进行理论教学、后期安排临床实习，存在实习时间过于集中、学生理论与实习脱节的弊端。笔者选取日照市人民医院这一多家医学院校临床教学医院，2005年9月—2014年7月对新接收的高等医学院校临床本科1398名医学生，执行教学任务，采用随机抽样的方法，分成 “全程实习教学模式”的观察组700名和 “小二段”教学模式的对照组698名，制定和使用实习手册、OSCE考核及自行设计临床教学质量问卷调查量表，对调查问卷进行了信度和效度调查，预试后确定考评细则，进行登记、记录、理论考试、技能考核，医学生身心健康、医患沟通、人文关怀及对临床科室冲击力影响采用调查问卷的方式进行考评，统计分析教学质量的差异。单项因素分析，在人文关怀为（x 2 ＝5.958， P ＝0.015）、爱伤观念（ x 2 ＝7.331， P ＝0.007）、医患沟通（x 2 ＝32.342， P ＝0.000）、实践技能（x 2 ＝10.664， P ＝0.001）、创造思维能力（ x 2 ＝4.936， P ＝0.026）、学生身心健康（ x 2 ＝6.224， P ＝0.013）和对临床影响（x 2 ＝4.151， P ＝0.042）两组差异有统计学意义（ P ＜0.05）；而理论知识（x 2 ＝0.222， P ＝0.637）指标两组差异无统计学意义（ P ＞0.05）；总体评价观察组采用“全程实习教学模式”临床教学质量优于传统“小二段”教学对照组（x 2 ＝12.237， P ＝0.001）， P ＜0.05。基于临床“全程实习教学模式”，构建新型实习临床实践教学模式，较传统的“小二段”教学模式，在医学生的医患沟通、爱伤观念、理论基础知识、临床实践技能及研究生录取率等方面都明显提高。不断改进和完善OSCE考试会使评价更合理、更客观、更公正。
Coherency Strain Effects on the Optical Response of Core/Shell Heteronanostructures (2003)

Core/shell-structured CdSe/CdS nanoparticles were prepared by a one-pot procedure. The interface effect was studied by steady-state and time-resolved photoluminescence spectroscopy. Coherency strain across the CdSe/CdS interface is addressed to rationalize the measured optical response. The optical properties of the different core/shell systems agree with Matthews−Blakeslee theory, which predicts a critical thickness for a defect-free shell of less than two monolayers of capping material for the CdSe/CdS system.
Essential structure of<i>E. coli</i>promoter effect of spacer length between the two consensus sequences on promoter function (1983)

A promoter with the consensus sequence(TTGACA and TATAAT) at -35 and -10 regions was constructed, and the distance between the two consensus sequences was independently altered at two restriction sites. In an in vitro transcription system, a maximum activity was observed at the spacer length of 17 base-pairs regardless of the sites of space adjustment. Evidence was also provided that the start point of transcription was fixed by the consensus sequence at the -10 region.
Animal models of the mechanisms of action of repetitive transcranial magnetic stimulation (RTMS): Comparisons with electroconvulsive shock (ECS) (2000)

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive means of brain stimulation with a broad range of basic neuroscience and potential future clinical applications. Recent animal studies have shed some light on the mechanisms of action of rTMS, and broadened our understanding of how this intervention affects brain functioning acutely and chronically. Differences in the physical properties of magnetic and electrical stimulation result in marked disparities in the amount and distribution of electrical current induced in the brain; nevertheless, rTMS shares many of the behavioral and biochemical actions of electroconvulsive shock (ECS) and other antidepressant treatments. rTMS reduces immobility in the Porsolt swim task and enhances apomorphine-induced stereotypy, as does ECS. Although rTMS can induce a seizure when given at high enough doses, most studies have found subconvulsive levels of rTMS to be anticonvulsant. rTMS acutely modulates dopamine and serotonin content and turnover rates. Chronic rTMS modulates cortical beta-adrenergic receptors, reduces frontal cortex 5-HT2 receptors, increases 5-hydroxytryptamine1A receptors in frontal cortex and cingulate, and increases N-methyl-D-aspartate receptors in the ventromedial hypothalamus, basolateral amygdala, and parietal cortex. More work will be needed to clarify and explore the mechanism behind the early suggestions that rTMS may exert long-term-potentiation-like or long-term-depression-like action on hippocampal activity. Finally, rTMS is emerging as yet another intervention, like ECS and other antidepressants, that can regulate gene expression and may have an impact on neuronal viability and synaptic plasticity.
Internet of Things Applications for Agriculture (2018)

The Internet of Things (IoT) represents a set of emerging technologies that is revolutionizing the agriculture industry and enabling farmers to contend with the enormous challenges in the twenty-first century. Precision agriculture (PA), which is also known as site-specific farming, represents an information-driven agricultural management system. The PA management system is designed to improve the agricultural processes by enabling continues soil/plant monitoring and precise treatment. With the latest technology, cloud-based IoT control center collects and processes real-time data of both crops and environment with regard to planting, fertilizing, and harvesting crops, at appropriate time and duration. Through this way, IoT-embedded PA can be achieved to increase the quality, quantity, sustainability, and cost effectiveness of agricultural production. The chapter provides an overview of the current situation and future prospects of IoT applications in PA. More specifically, typical IoT-based PA applications are presented in different sections, including precision irrigation, precision fertilization, crop disease and management, pest control, equipment automation, and precision livestock farming.
Immunogenetics of insulin-dependent diabetes mellitus in humans. (1989)

Diabetes mellitus is the second most prevalent chronic disease in children in the U.S. It is associated with severe manifestations which include blindness and circulation deficiencies as well as markedly increased risk of death. The etiology of diabetes mellitus remains a mystery although both genetic and environmental factors have been implicated. The geneticist is confronted with a number of obstacles in his attempts to unravel this problem, including differences in the definition of affected individuals. This matter was certainly clarified by the separation of noninsulin-dependent diabetes (NIDDM) and insulin-dependent diabetes mellitus (IDDM) into two separate disease entities. Twin studies, however, show that IDDM cannot be entirely due to genetic causes as concordance is no more than about 50%. Although the disease is then clearly not inherited per se, the "susceptibility" to diabetes seems almost surely inherited and, provided this susceptibility, the disease can be brought on by environmental factors. Until the underlying mechanism causing IDDM is completely ascertained, we have to rely on genetic markers to approach the study of the inheritance thereof. Since, in the early 1970s, research by Nerup's and Cudworth's groups revealed associations between the HLA-B locus and IDDM, the HLA markers are considered the classical genetic markers for IDDM susceptibility. In this paper, we review the nature of the genetic susceptibility to IDDM and the possible environmental factors which can bring on the disease.
Guilty and Gay, A Recipe for Execution in American Courtrooms: Sexual Orientation as a Tool for Prosecutorial Misconduct in Death Penalty Cases (2001)

Many input devices are available for interacting with computers, but the computer mouse is still the most popular device for interaction. People who suffer from involuntary tremor have difficulty using the mouse in the normal way. The target participants of this research were individuals who suffer from Parkinson's disease. Tremor in limbs makes accurate mouse movements impossible or difficult without any assistive technologies to help. This study explores a new assistive technique-adaptive path smoothing via B-spline (APSS)-to enhance mouse controlling based on user's tremor level and type. APSS uses Mean filtering and B-spline to provide a smoothed mouse trajectory. Seven participants who have unwanted tremor evaluated APSS. Results show that APSS is very promising and greatly increases their control of the computer mouse. Result of user acceptance test also shows that user perceived APSS as easy to use. They also believe it to be a useful tool and intend to use it once it is available. Future studies could explore the possibility of integrating APSS with one assistive pointing technique, such as the Bubble cursor or the Sticky target technique, to provide an all in one solution for motor disabled users.
NPC1 Gene Deficiency Leads to Lack of Neural Stem Cell Self-Renewal and Abnormal Differentiation Through Activation of p38 Mitogen-Activated Protein Kinase Signaling (2005)

Neural stem cells (NSCs) are capable of giving rise to neurons, glia, and astrocytes. Although self-renewal and differentiation in NSCs are regulated by many genes, such as Notch and Numb, little is known about the role of defective genes on the self-renewal and differentiation of NSCs from developing brain. The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative disease caused by a mutation of the NPC1 gene that affects the function of the NPC1 protein. The ability of NSC self-renewal and differentiation was investigated using a model of NPC1 disease. The NPC1 disorder significantly affected the self-renewal ability of NSCs, as well as the differentiation. NSCs from NPC1-/- mice showed impaired self-renewal ability compared with the NPC1+/+ mice. These alterations were accompanied by the enhanced activity of p38 mitogen-activated protein kinases (MAPKs). Further, the specific p38 MAPK inhibitor SB202190 improved the self-renewal ability of NSCs from NPC-/- mice. This indicated that the NPC1 deficiency can lead to lack of self-renewal and altered differentiation of NSCs mediated by the activation of p38 MAPK, impairing the generation of neurospheres from NPC1-/- Thus, the NPC1 gene may play a crucial role in NSC self-renewal associated with p38 MAPK.
Time-dependence and selectivity of immunosuppressive agents. (1979)

The effects of a variety of agents on the mouse antibody response to sheep red cells (SRC) and Escherichia coli lipopolysaccharide (LPS) were investigated. Agents formed two broad groups according to the time-dependence of their effects. Class I agents inhibited responses if given at any time over a broad period from before administration of antigen to 1-2 days afterwards. They included ionizing radiation, cortisone acetate, cholera toxin and several alkylating agents. Class II agents inhibited responses substantially only if given 1-2 days after the antigen. These agents were all either antimetabolites or vinca alkaloids. Class II agents had only moderate selectivity. When given at the time of maximal effectiveness they usually suppressed the response to SRC more than that to LPS. Some class I agents had striking selectivity. Radiation, cortisone acetate, and cholera toxin markedly suppressed the SRC response but had much less effect on the LPS response. In contrast, mitoclomine and its analogues, which are lipid-soluble alkylating agents, suppressed the response to LPS far more than that to SRC. Possible reasons for these differences in time-dependence and selectivity are discussed.
The Structure of Electroless Cobalt Alloy Films for Perpendicular Magnetic Recording Media (1986)

Two types of electroless Co alloy films, and , were prepared for perpendicular magnetic recording media. The correlation between their structure and magnetic properties was investigated and discussed as a function of film thickness. The magnetic properties of these two types of films showed different patterns of dependence with respect to the film thickness. The Co‐Ni‐Re‐P alloy film gave a higher (perpendicular coercivity) in regions where it was very thin; on the other hand, the Co‐Ni‐Re‐Mn‐P alloy film displayed a lower at the initial film thickness. The composition was observed with AES measurements to be nearly independent of film thickness. The clear columnar structure of both types of films was confirmed by scanning electron microscopy (SEM) and especially by transmission electron microscopy (TEM) observations. Only the reflection high energy electron diffraction (RHEED) patterns for both types of film clearly showed different dependence patterns with respect to the film thickness. The Co‐Ni‐Re‐P film displayed a very highly c‐axis oriented structure even at the initial thin film stage. On the other hand, the Co‐Ni‐Re‐Mn‐P film showed a dependence of the degree of c‐axis orientation on the film thickness, which increased with film thickness. The differences in magnetic properties as a function of thickness were assumed to be due to the degrees of c‐axis orientation and change in magnetic domain structure.