gebhart/patrepeval huggingface dataset:
Cloning and characterization of Bacillus subtilis homologs of Escherichia coli cell division genes ftsZ and ftsA (1988)

The Bacillus subtilis homolog of the Escherichia coli ftsZ gene was isolated by screening a B. subtilis genomic library with anti-E. coli FtsZ antiserum. DNA sequence analysis of a 4-kilobase region revealed three open reading frames. One of these coded for a protein that was about 50% homologous to the E. coli FtsZ protein. The open reading frame just upstream of ftsZ coded for a protein that was 34% homologous to the E. coli FtsA protein. The open reading frames flanking these two B. subtilis genes showed no relationship to those found in E. coli. Expression of the B. subtilis ftsZ and ftsA genes in E. coli was lethal, since neither of these genes could be cloned on plasmid vectors unless promoter sequences were first removed. Cloning the B. subtilis ftsZ gene under the control of the lac promoter resulted in an IPTGs phenotype that could be suppressed by overproduction of E. coli FtsZ. These genes mapped at 135 degrees on the B. subtilis genetic map near previously identified cell division mutations.
Phase Behavior of Lecithin at the Oil/Water Interface (1996)

In order to elucidate the mechanism for the formation of an interfacial film providing enhanced emulsion stability by lecithin, we performed dynamic contacting experiments in which water was brought into contact with a solution of the phospholipid in n-decane. Two main phenomena were observed in the vicinity of the interfacial boundary on the side of the nonaqueous phase. The first to be noted was the formation of a thick interfacial film, visible even to the naked eye. The second was the separation of a liquid phase. On the basis of the combined data from our current and previous experiments, we suggest the mechanism for interfacial processes of which the basis is the lecithin organogel formation. Water transferring from aqueous solution into the nonpolar phase through a hydration of the adsorbed phospholipid promotes a sequence of phase or pseudophase transitions near the phase boundary between immiscible liquids: spherical reverse micelles → three-dimensional network from entangled wormlike micelles → organogel separation into a diluted solution and a compact gel or solid mass precipitating on the interfacial boundary.
A high-dynamic range SiGe low-noise amplifier for X-band radar applications (2012)

In this paper, we present a high-dynamic range (HDR) LNA in 0.25-µm SiGe BiCMOS technology, aiming for X-band radar applications. LNA is designed in two-stages and each stage is a cascode topology using HBTs. First stage is optimized for noise performance while second stage is optimized for high output power. LNA design includes inductive degeneration and optimization of transistor sizes for simultaneous input noise-power match, wide-band input-output matching, DC bias circuitry to increase linearity, inter-stage matching optimized for gain flatness, etc. In 8.5–11.5 GHz band, the LNA achieves 24–27 dB flat gain, 1.6–1.65 dB noise figure, better than 15 dB input-output return loss, 16 dBm output P1dB and 24.7 dBm OIP 3 using 1.3×0.9 mm2 chip area including bond pads, with a power consumption of 115 mW.
Microstructure and crystallographic texture of an ultrafine grained C–Mn steel and their evolution during warm deformation and annealing (2004)

The evolution of microstructure and texture of a 0.2%C–Mn steel during large strain warm deformation and subsequent annealing has been investigated. The process of grain subdivision during warm deformation is essential for the formation of ultrafine grains in such a material. The study reveals that pronounced recovery instead of primary recrystallization is required to obtain a large fraction of high-angle grain boundaries (HAGBs) as a prerequisite for the development of ultrafine grains in the course of warm deformation. The prevalence of primary recrystallization instead of recovery is not generally beneficial in this context since it reduces significantly the dislocation density and removes the substructure which is important for the gradual formation of subgrains and, finally, of ultrafine grains which are surrounded by HAGBs. Consistently, the texture of the ultrafine grained 0.2%C–Mn steel observed after large strain warm deformation and subsequent annealing, consists primarily of the α-(〈1 1 0〉∥RD) texture fiber which indicates strong recovery. The γ-(〈1 1 1〉∥ND) texture fiber which is typical of recrystallized rolled ferritic steels does not appear. The process occurring during the deformation and subsequent annealing can, therefore, be interpreted as a pronounced recovery process during which new grains are created without preceding nucleation.
Avionic Architectures Incorporating Optical Fibre Technology (2006)

This paper describes some of the work which is being undertaken within a UK National programme entitled 'Future Optical Network Distribution for Aerospace' (FONDA). As part of the FONDA programme, studies have been undertaken to investigate the impact that optical technology can have on solving the problems faced by the next generation of avionic data network
Retinoblastoma tumor suppressor protein–dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit (2007)

The retinoblastoma tumor suppressor protein (pRb) is involved in mitotic exit, promoting the arrest of myoblasts, and myogenic differentiation. However, it is unclear how permanent cell cycle exit is maintained in differentiated muscle. Using RNA interference, expression profiling, and chromatin immunoprecipitations, we show that pRb is essential for cell cycle exit and the differentiation of myoblasts and is also uniquely required to maintain this arrest in myotubes. Remarkably, we also uncover a function for the pRb-related proteins p107 and p130 as enforcers of a G2/M phase checkpoint that prevents progression into mitosis in cells that have lost pRb. We further demonstrate that pRb effects permanent cell cycle exit in part by maintaining trimethylation of histone H3 lysine 27 (H3K27) on cell cycle genes. H3K27 trimethylation silences other genes, including Cyclin D1, in a pRb-independent but polycomb-dependent manner. Thus, our data distinguish two distinct chromatin-based regulatory mechanisms that lead to terminal differentiation.
Characterization of embedded MgO/ferromagnet contacts for spin injection in silicon (2008)

In this work we present the structural and electrical characterization of sputter-deposited CoFe(B)/MgO/Si metal-insulator-semiconductor tunneling junctions for injection and detection of spin polarized current in silicon. The multilayers have been deposited in 700 nm deep trenches, patterned in thick SiO2 dielectric, on n- and p-doped wafers. The films inside the trenches are continuous with a correlated and low roughness. The MgO barrier grows amorphous without indication of pinholes. The dc and ac transport properties of the junctions were studied as a function of temperature and frequency. A relatively high interface trap density at the MgO/Si-interface is extracted from admittance spectra measurements. Transport is dominated by majority carriers in the case of n-doped and by minority carriers for the p-doped wafers. This leads to distinct rectification characteristics for the two wafer types, which would significantly influence the spin injection efficiency of the tunneling junctions.
Superconductor Electronics: Status and Outlook (2018)

Abstract Superconductor electronics combines passive and active superconducting components and sometimes normal resistors into functional circuits and systems that also include room-temperature electronics for amplification, power sources, necessary controls, etc., usually computer operated. Furthermore, complete systems include magnetic and electromagnetic shielding, cryogenic enclosures, and increasingly a cryocooler in self-contained units. Components or devices of low or high critical temperature superconductors include inductances (coils), passive transmission lines, resonators, antennae, filters, as well as active elements: Josephson junctions, Josephson oscillators, and superconducting quantum interference devices. Of multiple demonstrated applications, mostly but not only in science and metrology, currently most successful are voltage standards, astronomy detectors and large telescope cameras, instruments for material characterization, and magnetometers for geomagnetic prospecting. Major current efforts concentrate on energy-efficient high-end computing and quantum computing. The outcomes of these efforts are likely to be known in the course of the following decade.
The primary antibacterial defense mechanism of the bladder. (1975)

We have developed a model in rabbits for quantitatively determining the attachment of microbial organisms to the vesical mucosa. Our data suggest that the bladder has a primary antibacterial defense mechanism that serves to interrupt microbial attachment. This mechanism seems to be secretory, since after destruction with acid, the resistance to microbial binding returns in less than 24 hr.
Pillaring of layered titanates by polyoxo cations of aluminum (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPillaring of layered titanates by polyoxo cations of aluminumSoofin Cheng and Tzun Chin WangCite this: Inorg. Chem. 1989, 28, 7, 1283–1289Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/ic00306a016https://doi.org/10.1021/ic00306a016research-articleACS PublicationsRequest reuse permissionsArticle Views293Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Challenges in development of the American Sign Language Lexicon Video Dataset (ASLLVD) corpus (2012)

The American Sign Language Lexicon Video Dataset (ASLLVD) consists of videos of >3,300 ASL signs in citation form, each produced by 1-6 native ASL signers, for a total of almost 9,800 tokens. This dataset, including multiple synchronized videos showing the signing from different angles, will be shared publicly once the linguistic annotations and verifications are complete. Linguistic annotations include gloss labels, sign start and end time codes, start and end handshape labels for both hands, morphological and articulatory classifications of sign type. For compound signs, the dataset includes annotations for each morpheme. To facilitate computer vision-based sign language recognition, the dataset also includes numeric ID labels for sign variants, video sequences in uncompressed-raw format, camera calibration sequences, and software for skin region extraction. We discuss here some of the challenges involved in the linguistic annotations and categorizations. We also report an example computer vision application that leverages the ASLLVD: the formulation employs a HandShapes Bayesian Network (HSBN), which models the transition probabilities between start and end handshapes in monomorphemic lexical signs. Further details and statistics for the ASLLVD dataset, as well as information about annotation conventions, are available from http://www.bu.edu/asllrp/lexicon.
Finding Alternate Features in Lasso (2016)

We propose a method for finding alternate features missing in the Lasso optimal solution. In ordinary Lasso problem, one global optimum is obtained and the resulting features are interpreted as task-relevant features. However, this can overlook possibly relevant features not selected by the Lasso. With the proposed method, we can provide not only the Lasso optimal solution but also possible alternate features to the Lasso solution. We show that such alternate features can be computed efficiently by avoiding redundant computations. We also demonstrate how the proposed method works in the 20 newsgroup data, which shows that reasonable features are found as alternate features.
Patatin-Related Phospholipase pPLAIIIβ-Induced Changes in Lipid Metabolism Alter Cellulose Content and Cell Elongation in <i>Arabidopsis</i>   (2011)

The release of fatty acids from membrane lipids has been implicated in various plant processes, and the patatin-related phospholipases (pPLAs) constitute a major enzyme family that catalyzes fatty acid release. The Arabidopsis thaliana pPLA family has 10 members that are classified into three groups. Group 3 pPLAIII has four members but lacks the canonical lipase/esterase consensus catalytic sequences, and their enzymatic activity and cellular functions have not been delineated. Here, we show that pPLAIIIβ hydrolyzes phospholipids and galactolipids and additionally has acyl-CoA thioesterase activity. Alterations of pPLAIIIβ result in changes in lipid levels and composition. pPLAIIIβ-KO plants have longer leaves, petioles, hypocotyls, primary roots, and root hairs than wild-type plants, whereas pPLAIIIβ-OE plants exhibit the opposite phenotype. In addition, pPLAIIIβ-OE plants have significantly lower cellulose content and mechanical strength than wild-type plants. Root growth of pPLAIIIβ-KO plants is less sensitive to treatment with free fatty acids, the enzymatic products of pPLAIIIβ, than wild-type plants; root growth of pPLAIIIβ-OE plants is more sensitive. These data suggest that alteration of pPLAIIIβ expression and the resulting lipid changes alter cellulose content and cell elongation in Arabidopsis.
Structural Properties of Ionomers (1989)

▪ Abstract The phase-field method has recently emerged as a powerful computational approach to modeling and predicting mesoscale morphological and microstructure evolution in materials. It describes a microstructure using a set of conserved and ...Read More
IgG to Various Beta-Glucans in a Human Adult Population (2011)

IgG to β-(1,3)- and β-(1,6)-glucans can be found in normal human sera. β-(1,6)-glucans appear to be much more potent antigens. The health impact of high anti-β-(1,6)-glucan antibody levels remains unclear and further investigations are needed.
The influence of eurocentricity on engineering courses and an approach to their transformation (2002)

This paper lists some problems facing the engineering profession, particularly, its bad image, the difficulty students have in transferring between tertiary institutions, and the lack of interest the public have in engineering. It shows that many of these problems are the result of two fundamental causes: the structure of the engineering degree and the content of the degree. The paper suggests changes that could be made to both these aspects of the engineering degree, and shows how these changes could solve many of the problems listed at the beginning of the paper. It ends by suggesting some areas in which further investigation is necessary, particularly the bureaucracy required to administer the new degree structure.
Calmodulin Differentially Modulates Smad1 and Smad2 Signaling (2000)

The members of the Smad protein family are intracellular mediators of transforming growth factor beta (TGF-beta) signaling. Smad1 transduces bone morphogenetic protein signals, inducing formation of ventral mesoderm in Xenopus embryos, whereas Smad2 transduces activin/TGF-beta signals, generating dorsal mesoderm. Calmodulin directly binds to many Smads and was shown to down-regulate Smad2 activity in a cell culture system (Zimmerman, C. M., Kariapper, M. S. T., and Mathews, L. S. (1997) J. Biol. Chem. 273, 677-680). Here, we extend those data and demonstrate that calmodulin alters Smad signaling in living embryos, increasing Smad1 activity while inhibiting Smad2 function. To characterize this regulation, we undertook a structure-function analysis and found that calmodulin binds to two distinct and conserved regions in both Smad1 and Smad2. Receptor tyrosine kinase signaling also modifies Smad activity (Kretzschmar, M., Doody, J., and Massagué, J. (1997) Nature 389, 618-622; Kretzschmar, M., Doody, J., Timokhina, I., and Massagué, J. (1999) Genes Dev. 13, 804-816; de Caestecker, M. P., Parks, W. T., Frank, C. J., Castagnino, P., Bottaro, D. P., Roberts, A. B., and Lechleider, R. J. (1998) Genes Dev. 12, 1587-1592). We show that calmodulin binding to Smads inhibits subsequent Erk2-dependent phosphorylation of Smads and vice versa. These observations suggest the presence of a cross-talk between three major signaling cascades as follows: Ca(2+)/calmodulin, receptor tyrosine kinase, and TGF-beta pathways.
Vehicle license plate detection and recognition (2010)

In this work, we develop a license plate detection and recognition method using a SVM (Support Vector Machine) classifier with HOG (Histogram of Oriented Gradients) features.The system performs window searching at different scales and analyzes the HOG feature using a SVM and locates their bounding boxes using a Mean Shift method.A car head and rear detection method was also proposed to accelerate the time consuming scanning process.A comparison of the performance for different cell and block sizes of HOG feature is provided, and four rounds of bootstrapping was performed to achieve better detection performance.Our license plate detection results show that this method is relatively insensitive to variations in illumination, license plate patterns, camera perspective and background variations.We tested our method on the Caltech data set (1999), and achieved a detection rate of 96.0%.We also studied how its performance is impacted by different levels of noise and motion blur.After license plate detection, we proceed to perform character segmentation and recognition using SVM classifiers with HOG features.In character segmentation, we need to deal with low contrast and tilted plates.The system performs window searching in different scales and analyzes the HOG feature using a SVM and locates their bounding boxes using Mean Shift.
Product piracy from nature: biomimetic microstructures and interfaces for high-performance optics (2008)

Micro and nanostructured optical components are evolved over millions of years in nature and show a wide application range as microlens arrays, diffractive or subwavelength structures in manifold biological systems. In this contribution we discuss the advantages and challenges to transfer the concepts based on the nature models to increase the performance of high-end optical systems in applications such as beam shaping and imaging. Especially we discuss the application of sophisticated statistical microlens arrays and diffractive structures in different fields such as lithography, inspection or for medical instruments. Additionally we focus on anti-reflection coatings which are commonly used to suppress reflection of light from the surface of optical components in the visible range. We report an innovative approach for the fast and cost-efficient fabrication of highly UV transmissive, anti-reflective optical interfaces based on self assembled gold nanoparticles.
Mannosylated Lipoarabinomannan Antagonizes<i>Mycobacterium tuberculosis–</i>Induced Macrophage Apoptosis by Altering Ca<sup>+2</sup>‐Dependent Cell Signaling (2000)

Mycobacterium tuberculosis-induced macrophage apoptosis can be inhibited by mannosylated lipoarabinomannan (ManLAM), although it induces tumor necrosis factor (TNF)-alpha and NO production, which participate in apoptosis induction. ManLAM also modulates Ca(+2)-dependent intracellular events, and Ca(+2) participates in apoptosis in different systems. Ca(+2) was assessed for involvement in M. tuberculosis-induced macrophage apoptosis and for modulation by ManLAM. The role of Ca(+2) was supported by the blockade of apoptosis by cAMP inhibitors and the Ca(+2) chelator, BAPTA/AM. These agents also inhibited caspase-1 activation and cAMP-responsive element-binding protein translocation without affecting TNF-alpha production. Infection of macrophages with M. tuberculosis induced an influx of Ca(+2) that was prevented by ManLAM. Similarly, M. tuberculosis infection-altered mitochondrial permeability transition was prevented by ManLAM and BAPTA/AM. Finally, ManLAM and BAPTA/AM reversed the effects of M. tuberculosis on p53 and Bcl-2 expression. ManLAM counteracts the alterations of calcium-dependent intracellular events that occur during M. tuberculosis-induced macrophage apoptosis.
A new model of active avoidance conditioning adequate for pharmacological studies. (1976)

A model of rapid learning (active avoidance conditioning), using rats, is described which induces retention depending on the number of trials to which the animals are submitted. For 3 trials (double stimulation) adequately spaced, the memory trace lasts for 48 hr, whilst 6 trails induce a trace for 10 days. One single application of the double stimulation does not give any apparent retention in normal rats for 24 hr. This experimental fact is used to study and screen the activity of substances on the learning process. Animals treated with piracetam, pemoline, methamphetamin, strychnine, pyritinol and meclofenoxate before this single trial, display evidence of retention 24 hr later. Other substances, with known clinical CNS activites, eg, tranquillizers, analgesics, etc... show no positive effect on the mnesic trace.
Strategic Targets of Essential Host-Pathogen Interactions (2005)

This review summarizes the present concepts regarding the biological processes that mediate intrinsic and innate host defense against microbial invasion of the lung. Innate immunity is the first line of defense of the higher organisms towards invading pathogens. It accomplishes a wide variety of activities including recognition and effector functions. The innate responses use phagocytic cells (macrophages, monocytes, and neutrophils), cells that release inflammatory mediators (basophils, mast cells, and eosinophils), and natural killer cells. The molecular component of innate responses includes complement, acute-phase proteins, and cytokines. Recognition of pathogen-associated molecular patterns is mediated by the pathogen receptors of the innate immune system, among these molecules toll-like receptors have emerged as fundamental components in the innate immune responses to infection, and a link between innate and adaptive immunity. Additional protection comes from polypeptide mediators of the innate host defense, such as the defensins and other antibiotic peptides. In view of the considerable burden in terms of mortality and morbidity that severe infections still pose worldwide, a better understanding of the biological basis of host-pathogen interactions opens stimulating future treatment perspectives.
Cholinesterase inhibition: is there evidence for disease-modifying effects? (2009)

Long-term inhibition of BuChE might be especially important when exploring any disease-modifying effects of cholinesterase inhibitors. Elucidation of the mechanisms involved could provide insights leading to the development of new treatments that modify the development and progression of AD.
Ustekinumab improves psoriasis-related gene expression in noninvolved psoriatic skin without inhibition of the antimicrobial response (2012)

These findings indicate that ustekinumab reduces psoriasis-related gene expression in noninvolved psoriatic skin, making it more resistant to exogenous triggering, without disturbing its antimicrobial response. In parallel, ustekinumab modulates important circulating inflammation-related proteins.