gebhart/patrepeval huggingface dataset:
Dissociation of extrastriate body and biological-motion selective areas by manipulation of visual-motor congruency (2009)

To date, several posterior brain regions have been identified that play a role in the visual perception of other people and their movements. The aim of the present study is to understand how these areas may be involved in relating body movements to their visual consequences. We used fMRI to examine the extrastriate body area (EBA), the fusiform body area (FBA), and an area in the posterior superior temporal sulcus (pSTS) that responds to patterns of human biological motion. Each area was localized in individual participants with independent scans. In the main experiment, participants performed and/or viewed simple, intransitive hand actions while in the scanner. An MR-compatible camera with a near-egocentric view of the participant's hand was used to manipulate the relationship between motor output and the visual stimulus. Participants' only view of their hands was via this camera. In the Compatible condition, participants viewed their own live hand movements projected onto the screen. In the Incompatible condition, participants viewed actions that were different from the actions they were executing. In pSTS, the BOLD response in the Incompatible condition was significantly higher than in the Compatible condition. Further, the response in the Compatible condition was below baseline, and no greater than that found in a control condition in which hand actions were performed without any visual input. This indicates a strong suppression in pSTS of the response to the visual stimulus that arises from one's own actions. In contrast, in EBA and FBA, we found a large but equivalent response to the Compatible and Incompatible conditions, and this response was the same as that elicited in a control condition in which hand actions were viewed passively, with no concurrent motor task. These findings indicate that, in contrast to pSTS, EBA and FBA are decoupled from motor systems. Instead we propose that their role is limited to perceptual analysis of body-related visual input.
A Novel Miniaturized Multimodal Bioreactor for Continuous <i>In Situ</i> Assessment of Bioartificial Cardiac Tissue During Stimulation and Maturation (2010)

Stem cell-based cardiac tissue engineering is a promising approach for regenerative therapy of the injured heart. At present, the small number of stem cell-derived cardiomyocytes that can be obtained using current culture and enrichment techniques represents one of the key limitations for the development of functional bioartificial cardiac tissue (BCT). We have addressed this problem by construction of a novel bioreactor with functional features of larger systems that enables the generation and in situ monitoring of miniaturized BCTs. BCTs were generated from rat cardiomyocytes to demonstrate advantages and usefulness of the bioreactor. Tissues showed spontaneous, synchronized contractions with cell orientation along the axis of strain. Cyclic stretch induced cardiomyocyte hypertrophy, demonstrated by a shift of myosin heavy chain expression from the alpha to beta isoform, together with elevated levels of atrial natriuretic factor. Stretch led to a moderate increase in systolic force (1.42 ± 0.09 mN vs. 0.96 ± 0.09 mN in controls), with significantly higher forces observed after β-adrenergic stimulation with noradrenalin (2.54 ± 0.11 mN). Combined mechanical and β-adrenergic stimulation had no synergistic effect. This study demonstrates for the first time that mechanical stimulation and direct real-time contraction force measurement can be combined into a single multimodal bioreactor system, including electrical stimulation of excitable tissue, perfusion of the culture chamber, and the possibility of (fluorescence) microscopic assessment during continuous cultivation. Thus, this bioreactor represents a valuable tool for monitoring tissue development and, ultimately, the optimization of stem cell-based tissue replacement strategies in regenerative medicine.
Chaos in biological systems (1985)

Chaos is a widespread and easily recognizable phenomenon that hardly anybody took notice of until recently. The reason may be that chaos has something profoundly counterintuitive about it. It will not fit easily into any familiar cause–effect frame. The best introduction to chaos is by the way of an example. Consider a leaking faucet (Shaw, 1984). When the weight of the accumulating drop exceeds the surface tension the drop falls and a new drop begins to form. If the leak is small and the pressure in the faucet is constant, the time taken for the drop to reach the critical weight is constant. The dripping is perfectly periodic, the period depending on the leak rate. If the leak is slightly increased, the period of dripping will decrease slightly and vice versa. However, somewhere beyond this point the leaking faucet becomes a nuisance. When the leak is increased beyond a certain point the dripping looses its regularity. The time interval between the drops will first alternate periodically between a short and a long time interval. After a further increase of the leak this double periodic pattern will become unstable and change into a new pattern where four different time intervals between the drops alternate periodically. As the leak is further increased the period will double again and again and finally the dripping becomes completely irregular without any repeating pattern. When this occurs we are observing chaos. At the same time we are posed with the problem of understanding how such a ridiculously simple system can show random behaviour.
Transmission of polar substituent effects in bicycloalkane systems. Synthesis and nuclear magnetic resonance study (carbon-13 and fluorine-19) of 4-substituted bicyclo[2.2.1]hept-1-yl fluorides (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransmission of polar substituent effects in bicycloalkane systems. Synthesis and nuclear magnetic resonance study (carbon-13 and fluorine-19) of 4-substituted bicyclo[2.2.1]hept-1-yl fluoridesWilliam Adcock, Anil N. Abeywickrema, and Gaik B. KokCite this: J. Org. Chem. 1984, 49, 8, 1387–1397Publication Date (Print):April 1, 1984Publication History Published online1 May 2002Published inissue 1 April 1984https://pubs.acs.org/doi/10.1021/jo00182a014https://doi.org/10.1021/jo00182a014research-articleACS PublicationsRequest reuse permissionsArticle Views284Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optical Properties and Applications of Photochromic Glass (1966)

Corning Glass Works has recently developed a series of inorganic bulk photochromic materials. The present paper is concerned with the results of an extensive laboratory investigation of their properties. It is shown that the fatigueless reversibility and the optical characteristics of these glasses hold definite. promise for several applications.
Stromal Fibroblasts Mediate Extracellular Matrix Remodeling and Invasion of Scirrhous Gastric Carcinoma Cells (2014)

Scirrhous gastric carcinoma (SGC) has the worst prognosis of all gastric cancers, owing to its rapid expansion by invasion and frequent peritoneal dissemination. Due to the increased proliferation of stromal fibroblasts (SFs) that occurs within SGC lesions and the peritoneal metastatic sites, SFs have been proposed to support the progression of this disease. However, the biological and molecular basis and the pathological role of the intercellular interaction between SGC cells and SFs remain largely unknown. In this study, we investigated the role of SFs in the invasion of the extracellular matrix (ECM) by SGC cells. When SGC cells were cocultured with SFs derived from SGC tissue on three-dimensional (3D) Matrigel, they were attracted together to form large cellular aggregates that invaded within the Matrigel. Time-lapse imaging revealed that this process was associated with extensive contraction and remodeling of the ECM. Immunofluorescence and biochemical analysis showed that SGC cells stimulate phosphorylation of myosin light chain and actomyosin-mediated mechanical remodeling of the ECM by SFs. By utilizing this assay system for inhibitor library screening, we have identified several inhibitors that potently suppress the cooperation between SGC cells and SFs to form the invasive structures. Among them, a Src inhibitor dasatinib impaired the interaction between SGC cells and SFs both in vitro and in vivo and effectively blocked peritoneal dissemination of SGC cells. These results indicate that SFs mediate mechanical remodeling of the ECM by SGC cells, thereby promoting invasion and peritoneal dissemination of SGC.
Gypsophila (1939)

Gypsophila Get access J. E. H. R. J. E. H. R. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 177, Issue 8, 19 August 1939, Page 137, https://doi.org/10.1093/nq/177.8.137b Published: 19 August 1939
Volterra and Wiener Equalizers for Short-Reach 100G PAM-4 Applications (2017)

Unlike ultralong coherent optical systems that seriously suffer from fiber nonlinearities, short-reach noncoherent systems such as data center interconnections, which utilize small, cheap, and low-bandwidth components, are sensitive to nonlinearities that are mainly produced by devices responsible for electrical signal amplification, modulation, and demodulation. One of the most promising schemes for these applications is the four-level pulse amplitude modulation format combined with intensity modulation and direct detection; however, it can be significantly degraded by linear and nonlinear intersymbol interference. Linear and nonlinear signal degradation can efficiently be handled by different types of equalizers. In many cases, the straightforward linear equalizer cannot lower the error rate at the acceptable level. Therefore, much stronger equalizers based on nonlinear models such as the Volterra series are proposed. Volterra filter that can also be orthogonalized by the Wiener model is well described in the existing literature, and, in this paper, we investigate the most critical points related to high-speed Volterra filter design and implementation. Several experiments are carried out in order to indicate filter requirements/complexity, acquisition, and stability. We also provide a simple guidance for filter complexity reduction and useful hints for channel acquisition.
X-chromosome deletions in embryo-derived (EK) cell lines associated with lack of X-chromosome inactivation (1985)

The predictions of a model for the initiation of X-chromosome inactivation based on a single inactivation centre were tested in a cytogenetic study using six different embryo-derived (EK) stem cell lines, each with a different-sized deletion of the distal part of one of the X-chromosomes. Metaphase chromosomes were prepared by the Kanda method from each cell line in the undifferentiated state and after induction of differentiation, and cytogenetic evidence sought for a dark-staining inactive X-chromosome. The results confirm the predictions of the model in that when the inactivation centre is deleted from one of the X-chromosomes neither X present in a diploid cell can be inactivated, and in addition considerably further localize the position of the inactivation centre on the X-chromosome.
Cluster-Based Naming for Reliable Distributed Systems. (1984)

The authors introduce a new concept in naming for distributed systems, which is motivated by the need for easily-migratable objects, which is in turn motivated by the need for reliable operations. This naming scheme attempts to solve certain problems associated with correcting remote references to objects which are subject to migration. A name is divided into two parts, of which the first is used to locate the possible current sites of a target object and the second is used to select the specific site (and hence the object) in which the object is to be found. The set of possible sites constitutes a cluster. The authors discuss how clusters and cluster-based naming can be applied to enhance the migratability, and thus reliability, of a system in our context. The same scheme may be applied for other purposes such as load-balancing, protection, and support of transparent services.
Use of technetium-99m-liposomes in tumor imaging. (1994)

The results of this study indicate that both formulations could be used as tumor imaging agents, but that neutral 99mTc-liposomes would be more suitable as a drug delivery agent due to their increased total uptake by the tumor and decreased nonspecific uptake by the reticuloendothelial system.
Selective reduction of .alpha.-keto acids to .alpha.-hydroxy acids by phosphites (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleSelective reduction of .alpha.-keto acids to .alpha.-hydroxy acids by phosphitesTakeo Saegusa, Shiro Kobayashi, Yoshiharu Kimura, and Tsunenori YokoyamaCite this: J. Org. Chem. 1977, 42, 16, 2797–2798Publication Date (Print):August 1, 1977Publication History Published online1 May 2002Published inissue 1 August 1977https://pubs.acs.org/doi/10.1021/jo00436a039https://doi.org/10.1021/jo00436a039research-articleACS PublicationsRequest reuse permissionsArticle Views227Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Xylanase B from <i>Neocallimastix patriciarum</i> contains a non-catalytic 455-residue linker sequence comprised of 57 repeats of an octapeptide (1994)

A Neocallimastix patriciarum cDNA library was screened for xylanase-expressing clones, which were distinct from the previously characterized N. patriciarum xynA cDNA encoding xylanase A. A single cDNA, designated xynB, which did not exhibit homology with xynA, was isolated. Northern-blot analysis of mRNA from Avicel-grown N. patriciarum showed that xynB hybridized to a 3.4 kb mRNA species. The nucleotide sequence of xynB revealed a single open reading frame of 2580 bp coding for a protein designated xylanase B (XYLB), of M(r) 88,066. The primary structure of XYLB was comprised of a 21-residue N-terminal signal peptide, followed by a 304-amino acid sequence that exhibited substantial homology with the catalytic domains of family F xylanases. The N-terminal domain was linked to a C-terminal 70-residue sequence by a putative linker region, comprising 12 tandem repeats of a sequence containing TLPG as the core sequence, followed by an octapeptide XSKTLPGG where X can be S, K or N, which was repeated in tandem 45 times. Truncated derivatives of xynB encoding the N-terminal 338 residues directed the synthesis of a functional xylanase, confirming that the region of XYLB, which exhibited homology with family F xylanases, constitutes the catalytic domain. To investigate the catalytic properties of XYLB, the catalytic domain was fused to the Escherichia coli maltose-binding protein, and the fusion protein purified by amylose affinity chromatography. The purified enzyme hydrolysed oat, rye and wheat arabinoxylan releasing primarily xylobiose, xylotriose and some xylose. The XYLB fusion did not cleave any cellulosic substrates. The data presented in this report suggest that the multiple xylanases of N. patriciarum arose, not through the duplication of a single gene, but by the transfer of distinct xylanase-encoding DNA sequences into the anaerobic fungus. The possible origin of the xynB gene is discussed.
Educational administration and social justice (2005)

\n\t\t\t\t\tAfter observing that texts in educational administration have largely failed to address the problem of the justice and fairness of social and educational arrangements, this article goes on to examine the necessary relationships between ethical leadership, community and the notion of social justice. Such relationships are argued to be necessarily political, although the field of leadership has historically seen administration as a substitute for politics. The relationship between social justice and disadvantage is examined, as are current approaches to community, choice and diversity. The importance of both redistributive and recognitional approaches to social justice is emphasized as a basis for a model of educational administration centred on the problem of the justice and fairness of social and educational arrangements.<br />\n\t\t\t\t
Pre-earthquake ionospheric anomalies registered by continuous GPS TEC measurements (2004)

Abstract. In this paper we examine pre-earthquake ionospheric anomalies by the total electron content (TEC) derived from a ground-based receiver of the Global Positioning System (GPS). A 15-day running median of the TEC and the associated inter-quartile range (IQR) are utilized as a reference for identifying abnormal signals during all of the 20M≥6.0 earthquakes in the Taiwan area from September 1999 to December 2002. Results show that the pre-earthquake ionospheric anomalies appear during 18:00–22:00LT (LT=UT+8h) within 5 days prior to 16 of the 20M≥6.0 earthquakes. This success rate of 80% (=16/20%) suggests that the GPS TEC is useful to register pre-earthquake ionospheric anomalies appearing before large earthquakes. Key words. Ionosphere (ionospheric disturbances; ionosphere-atmosphere interactions)
Physico-chemical characteristics of papad (sajji) khar. (1970)

Papad khar (also known as sajji khar) is used in the preparation of papads (see preceding abstr.) to improve dough rolling properties and frying quality. It is an efflorescent ash obtained either from alkaline deposits in the soil or by burning a variety of plants, e.g. Salicornia, Arthrocnemum, Salsola, Haloxylon recurvum. 13 samples of papad khar obtained from different areas of India were examined and, on the basis of their appearance, classified into 3 groups. Ranges of the various characteristics examined were: sp. gr. of crystalline samples 1.245-1.738, bulk density of powdered samples 0.552-0.824; moisture 0.6-26.3%, total ash 71.7-96.5%, acid-insoluble ash 0-28.4%, carbonates 1.6-58.3%, bicarbonate 0-18.9%, chlorides 1.2-72.0%, Fe 0-5.5%, sulphate S 0.9-2.6%, and volatile sulphide S 0.5-1.6%. Since it is the bicarbonates and carbonates which have the most significant effects on papad quality it is recommended that papad khar be replaced by food grade carbonates to overcome the wide variation in the properties of this ash.
Experimental manipulations and marrow-derived factors which affect the outcome of bone marrow transplantation across the H-2 barrier in lethally irradiated mice. (1985)

A system is illustrated here for transplantation of bone marrow (BMT) across the H-2 barrier in conventionally raised mice. Timing of BM inoculation after supralethal irradiation, alteration of cellular composition of BM cell inoculum, sex of donor and recipient, inoculation or removal of BM-derived supernatants, use of BM-derived factors were all variables which profoundly affected survival, hemopoietic engraftment and induction of permanent, irreversible chimerism in different strains of mice (H-2d, H-2b, H-2k) transplanted with allogeneic BM. Inoculation of BM shortly after irradiation and addition or removal of plastic-adherent cells to the BM adversely affected survival and chimerism. Also inoculation of BM in its original supernatant containing all extracellular, endogenous BM factors resulted in increased mortality. BM-derived regulating factors (MRF) exerted variable effects in different H-2 combinations. However, heat-stable components of MRF greatly affected survival and chimerism. BM-derived supernatants and MRF from rabbit or different murine H-2 types thus seem to contain powerful inhibitors and promoters of BM engraftment. Promoters stimulate allogeneic BM engraftment, are heat-resistant and non-species specific. The different character and concentration of those factors between different H-2 types is also illustrated by their in vitro effects on BM cells. These results demonstrate that different experimental manipulations and factors which do not strictly depend on genetic diversity between donor and recipient profoundly affect allogeneic BMT. Adoption of manipulations combined with use of non-T cell depleted BM and the still largely unidentified BM-derived factors result in increment of survival and lasting chimerism without any manifestation of early or late graft versus-host disease (GVHD).
Serum lysophosphatidic acid concentrations measured by dot immunogold filtration assay in patients with acute myocardial infarction (2003)

In this study the relation between lysophosphatidic acid (LPA) and myocardial infarction was investigated, the typical and simplified methods for measuring serum LPA concentration by dot immunogold filtration assay (DIFA) based on a polyclonal antibody to LPA were developed, and serum LPA concentrations were measured in 31 patients with acute myocardial infarction (AMI) and 12 controls (blood donors) by DIFA. Serum LPA levels were raised more than twofold 8 h after the onset of AMI. Maximal elevation (10.43 mg/L) was found at 48-72 h following onset and remained higher than the control concentration (1.66 mg/L) 7 days after AMI. The rise in serum LPA concentration in AMI patients suggests that LPA might be involved in AMI-related pathophysiology in the cardiovascular system. The simplified DIFA developed in the present study for measuring serum LPA concentration is convenient and highly sensitive.