gebhart/patrepeval huggingface dataset:
High accurate robotic drilling with external sensor and compliance model-based compensation (2016)

High accurate absolute robot positioning is a requirement, and still a challenge, in many applications, such as drilling in the aerospace industry. The accuracy is affected due to many sources of errors from robot model, tool calibration, sensor and product uncertainties. While model-based error compensation cannot reach the desired accuracy, sensor-based compensation appears as the practical solution to increase the robot positioning accuracy. A structured analysis of the error sources in robotic manufacturing processes can facilitate error identification and further compensation. This paper describes an error source breaking down approach for analyzing robotic manufacturing processes. Moreover, an external sensor-based compensation is proposed for error reduction and error identification. Comparison with a compliance model-based compensation is performed. The proposed approach is applied to a robotic drilling process for aircraft manufacturing, considered a general and real industrial application. Further validation through experimentation is performed. The validation revealed a clear improvement in robot positioning accuracy and the benefits of the proposed error source structure for analysis.
Aggretin, a snake venom–derived endothelial integrin α2β1 agonist, induces angiogenesis via expression of vascular endothelial growth factor (2003)

Aggretin, a collagen-like alpha 2 beta 1 agonist purified from Calloselasma rhodostoma venom, was shown to increase human umbilical vein endothelial cell (HUVEC) proliferation and HUVEC migration toward immobilized aggretin was also increased. These effects were blocked by A2-IIE10, an antibody raised against integrin alpha 2. Aggretin bound to HUVECs in a dose-dependent and saturable manner, which was specifically inhibited by A2-IIE10, as examined by flow cytometry. Aggretin elicited significant angiogenic effects in both in vivo and in vitro angiogenesis assays, and incubation of HUVECs with aggretin activated phosphatidylinositol 3-kinase (PI3K), Akt, and extracellular-regulated kinase 1/2 (ERK1/2); these effects were blocked by A2-IIE10 or vascular endothelial growth factor (VEGF) monoclonal antibody (mAb). The angiogenic effect induced by aggretin may be via the production of VEGF because the VEGF level was elevated and VEGF mAb pretreatment inhibited Akt/ERK1/2 activation as well as the in vivo angiogenesis induced by aggretin. The VEGF production induced by aggretin can be blocked by A2-IIE10 mAb pretreatment. In conclusion, aggretin induces endothelial cell proliferation, migration, and angiogenesis by interacting with integrin alpha 2 beta 1 leading to activation of PI3K, Akt, and ERK1/2 pathways, and the increased expression of VEGF may be responsible for its angiogenic activity.
Antimicrobial Efficacy of Irradiation with Visible Light on Oral Bacteria<i>In Vitro</i>: A Systematic Review (2017)

More research concerning situation in a biofilm state is required.
EXTL2 and EXTL3 inhibition with siRNAs as a promising substrate reduction therapy for Sanfilippo C syndrome (2015)

Sanfilippo syndrome is a rare lysosomal storage disorder caused by an impaired degradation of heparan sulfate (HS). It presents severe and progressive neurodegeneration and currently there is no effective treatment. Substrate reduction therapy (SRT) may be a useful option for neurological disorders of this kind, and several approaches have been tested to date. Here we use different siRNAs targeting EXTL2 and EXTL3 genes, which are important for HS synthesis, as SRT in Sanfilippo C patients' fibroblasts in order to decrease glycosaminoglycan (GAG) storage inside the lysosomes. The results show a high inhibition of the EXTL gene mRNAs (around 90%), a decrease in GAG synthesis after three days (30-60%) and a decrease in GAG storage after 14 days (up to 24%). Moreover, immunocytochemistry analyses showed a clear reversion of the phenotype after treatment. The in vitro inhibition of HS synthesis genes using siRNAs shown here is a first step in the development of a future therapeutic option for Sanfilippo C syndrome.
Enzymic Optical Resolution of α,α-Difluoro-β-Hydroxyketones (1990)

Abstract Kinetic resolution of various α,α-difluoro-β-hydroxyketones was conducted by enantioselective hydrolysis of the corresponding acetates with lipase MY to afford optically active products. Both enantiomers of 3,3-difluoro-2-hydroxy-4-decanone were obtained in a highly enantioselective manner by screening enzymes and acyl groups.
Photochemical Upconversion: The Primacy of Kinetics (2014)

Incoherent photochemical upconversion is a process by which low-energy light can be converted into a higher-energy form with promising applications in solar energy conversion and storage, photocatalysis, biological imaging, and photochemical drug activation. Despite intensive research in recent years, there remains an underappreciation of the chemical kinetics that controls the efficiency of the upconversion process. Here, we provide a brief overview of research into photochemical upconversion and provide a tutorial to guide the design of efficient upconversion compositions. We further provide our perspective on where this area of research is heading and how very efficient systems will be developed.
Deficiency in p57Kip2 expression induces preeclampsia-like symptoms in mice (2002)

p57Kip2, a potent inhibitor of several cyclin/cyclin dependent kinase complexes (CDK ), is a paternally imprinted gene in both humans and mice, and here we show that pregnant mice which are heterozygous for p57Kip2 deficiency display symptoms similar to preeclampsia. p57-/+ (heterozygotes for p57Kip2 ) female mice that were mated with p57-/+ males showed hypertension, proteinuria, thrombocytopenia, decreased anti-thrombin III activity, and increased endothelin levels during late pregnancy. In their kidneys, endotheliosis of glomeruli were recognized along with fibrinoid or hyalinoid deposits. These characteristics were also observed in pregnant p57-/+ females that were mated with wild type males, but not in pregnant wild type females mated with p57-/+ males or wild type males. The pregnant p57-/+ mice had conceptuses both with and without p57Kip2 expression. The conceptuses without p57Kip2 expression showed trophoblastic hyperplasia, which mimics the hallmark proliferation of intermediate trophoblasts in clinical preeclampsia. It is suggested that the preeclampsia-like symptoms of the pregnant p57-/+ mice might have been induced by the conceptus(es) without p57Kip2 expression. In addition, pregnant p57-/+ mice might serve as a new animal model for preeclampsia characterized by trophoblastic hyperplasia.
The Algorithms of Intelligent TV Programs Recommendation Based on Data Mining (2012)

With the rapid development of information technology, the household electrical appliance industry quickly gets into the digital age. Although the intelligent TV provides users with more and more programs, its structure has become increasingly complex. In such situation it is more difficult for users to find the appropriate programs. The existing recommendation algorithms based on tag or search are not accurate. This paper puts forward solutions to obtain users' personal data based on Data Mining, and then carrys out the directional analysis of the personalized data. Lastly we push the recommended programs to users.
DNA Microarray Assessment of Putative <i>Borrelia burgdorferi</i> Lipoprotein Genes (2002)

A DNA microarray containing fragments of 137 Borrelia burgdorferi B31 putative lipoprotein genes was used to examine Lyme disease spirochetes. DNA from B. burgdorferi sensu stricto B31, 297, and N40; Borrelia garinii IP90; and Borrelia afzelii P/Gau was fluorescently labeled and hybridized to the microarray, demonstrating the degree to which the individual putative lipoprotein genes were conserved among the genospecies. These data show that a DNA microarray can globally examine the genes encoding B. burgdorferi lipoproteins.
Performance Analysis of Quasi-Orthogonal Space-Time Block Coded OFDM Systems (2004)

As a technique for high-quality multimedia service in down-link, the transmit diversity schemes using a orthogonal space-time block codes were proposed. But if the number of transmit antenna is three or more, it was impossible to obtain full diversity gain because of the decline of spectral efficiency. Accordingly, the quasi-orthogonal space-time block code that not required a additional bandwidth was proposed. But using a space-time block codes, the transmit diversity schemes were verified over quasi-static and frequency non-selective channels. Therefore, in this paper, we analyze the performance of OFDM systems, which a frequency selective channel equalized a frequency non-selective channel, adapting the quasi-orthogonal space-time block code, and compare they to the conventional orthogonal space-time block coded OFDM systems.
Refraction of 1-year-old children after atropine cycloplegia. (1979)

The refractions of 1648 children aged 11 to 13 months are reported. Atropine 1% was used for cycloplegia. 11.83% of the children had bilateral hypermetropia of +2.00 or more D. 13.23% of them had +1.50 or more D astigmatism in one or both eyes, and 6.5% had anisometropia. Anisometropia was significantly (P=0.000 001%) associated with bilateral hypermetropia, but even more significantly (P=0.000 000 4%) associated with astigmatism of +1.50 or more D in one or both eyes.
Expression of the SARS-CoV-2 <i>ACE2</i> Receptor in the Human Airway Epithelium (2020)

<b>Rationale:</b> Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease (COVID-19), a predominantly respiratory illness. The first step in SARS-CoV-2 infection is binding of the virus to <i>ACE2</i> (angiotensin-converting enzyme 2) on the airway epithelium.<b>Objectives:</b> The objective was to gain insight into the expression of <i>ACE2</i> in the human airway epithelium.<b>Methods:</b> Airway epithelia sampled by fiberoptic bronchoscopy of trachea, large airway epithelia (LAE), and small airway epithelia (SAE) of nonsmokers and smokers were analyzed for expression of <i>ACE2</i> and other coronavirus infection-related genes using microarray, RNA sequencing, and 10x single-cell transcriptome analysis, with associated examination of <i>ACE2</i>-related microRNA.<b>Measurements and Main Results:</b><i>1</i>) <i>ACE2</i> is expressed similarly in the trachea and LAE, with lower expression in the SAE; <i>2</i>) in the SAE, <i>ACE2</i> is expressed in basal, intermediate, club, mucus, and ciliated cells; <i>3</i>) <i>ACE2</i> is upregulated in the SAE by smoking, significantly in men; <i>4</i>) levels of miR-1246 expression could play a role in <i>ACE2</i> upregulation in the SAE of smokers; and <i>5</i>) <i>ACE2</i> is expressed in airway epithelium differentiated <i>in vitro</i> on air-liquid interface cultures from primary airway basal stem/progenitor cells; this can be replicated using LAE and SAE immortalized basal cell lines derived from healthy nonsmokers.<b>Conclusions:</b><i>ACE2</i>, the gene encoding the receptor for SARS-CoV-2, is expressed in the human airway epithelium, with variations in expression relevant to the biology of initial steps in SARS-CoV-2 infection.
Preparation of N-Substituted 1-(p-Hydroxyphenyl)-2-aminoethanols<sup>1</sup> (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of N-Substituted 1-(p-Hydroxyphenyl)-2-aminoethanols1John R. Corrigan, Marie-Jo Langerman, and Maurice L. MooreCite this: J. Am. Chem. Soc. 1945, 67, 11, 1894–1896Publication Date (Print):November 1, 1945Publication History Published online1 May 2002Published inissue 1 November 1945https://doi.org/10.1021/ja01227a004RIGHTS & PERMISSIONSArticle Views298Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (388 KB) Get e-Alerts Get e-Alerts
The insulin-like growth factor, somatomedin C, induces the synthesis of cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin in ovarian cells. (1986)

The actions of insulin and somatomedin C (insulin-like growth factor I) on cholesterol side-chain cleavage activity and the synthesis of cytochrome P-450scc and adrenodoxin were investigated in primary cultures of swine ovarian (granulosa) cells. Nanomolar concentrations of pure human somatomedin C stimulated biosynthesis of progesterone and 20 alpha-hydroxypregn-4-en-3-one. Moreover, in the presence of exogenous sterol substrate for cholesterol side-chain cleavage, somatomedin C significantly enhanced pregnenolone biosynthesis in a time- and dose-dependent manner. This augmentation of functional cholesterol side-chain cleavage activity was accompanied by a dose-dependent (2-16-fold) increase in [35S]methionine incorporation into specific immunoprecipitable cytochrome P-450scc and adrenodoxin. Micromolar concentrations of insulin (but not proinsulin or desoctapeptide) also induced synthesis of cholesterol side-chain cleavage constituents by 4-7-fold. These results demonstrate that an insulin-like growth factor, somatomedin C, exerts discrete differentiating effects on ovarian cells characterized by increased synthesis of immunospecific cytochrome P-450scc and adrenodoxin. Thus, we infer that somatomedin C may serve a critical role in the differentiation of steroidogenic cells in the mammalian ovary.
A blue-violet laser irradiation stimulates bone nodule formation of mesenchymal stromal cells by the control of the circadian clock protein (2007)

Mesenchymal stromal cells (MSCs) are multipotent cells, which are present in adult bone marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, and muscle. Their rapid and selective differentiation should provide the potential of new therapeutic approaches for the restoration of damaged or diseased tissue. However, several fundamental questions must be answered before it will be feasible to usefully predict and control MSCs responses to exogenous cytokines or genes. In particular, a better understanding of how specific factor may alter the fate of differentiation of MSCs is needed. In recent reports, circadian clock protein controls osteogenesis in vitro and in vivo. Here we show that a stimulation of a blue-violet laser irradiation regulates the differentiation of mouse MSCs to osteoblasts by change of the localization of a circadian rhythm protein, mouse Cryptochrome 1 (mCRY1). We found that a blue laser irradiation accelerated osteogenesis of MSCs. After laser irradiation, mCRY1 protein was translocated from cytoplasm to nucleus and mCRY1 mRNA level was downregulated thereafter. These results indicate that mCRY1, a blue-violet-light receptor and a master regulator of circadian rhythm, plays important roles in the regulation of the differentiation of MSCs. Since the differentiation of MSCs was easily regulated only by a laser irradiation, the potential of new therapeutic approaches for the restoration of damaged or diseased tissue is anticipated. Furthermore, our results obtained in this study may prove an excellent opportunity to gain insights into cross-talk between circadian rhythms and bone formation.
A novel optical phase locked loop architecture based on sub-carrier modulation (2004)

A novel sub-carrier based optical phase locked loop (SC-OPLL/spl trade/) is presented and demonstrated. Our method, based on CW laser and optical sub-carrier modulation, allows a much easier practical implementation of coherent detection than previous setups.
Extractive Summarization with SWAP-NET: Sentences and Words from Alternating Pointer Networks (2018)

We present a new neural sequence-tosequence model for extractive summarization called SWAP-NET (Sentences and Words from Alternating Pointer Networks). Extractive summaries comprising a salient subset of input sentences, often also contain important key words. Guided by this principle, we design SWAP-NET that models the interaction of key words and salient sentences using a new twolevel pointer network based architecture. SWAP-NET identifies both salient sentences and key words in an input document, and then combines them to form the extractive summary. Experiments on large scale benchmark corpora demonstrate the efficacy of SWAP-NET that outperforms state-of-the-art extractive summarizers.
O1‐05–08: Mid‐ and late‐life diabetes in relation to the risk of dementia: A population‐based twin study (2008)

Previous research has shown that diabetes increases dementia risk. This study aimed to verify the association between diabetes and the risk of dementia, Alzheimer's disease (AD) and vascular dementia (VaD) in twins, and to explore to what extent genetic and early life environmental factors contribute to this association. The study included 13,693 twin individuals aged ≥65 years, derived from the population-based Swedish Twin Registry. Dementia was diagnosed according to DSM-IV criteria by a two-step procedure that consisted of a cognitive screening and then full dementia workup. Information on diabetes and time at onset from midlife to late life was collected from the inpatient registry, self- or informant-reported history of diabetes and use of antidiabetic drugs. Data were analyzed following two strategies: 1) unmatched case-control analysis for all twins by using generalized estimating equation (GEE) models, and 2) matched case-control analysis for dementia-discordant twin pairs using conditional logistic regression. Of all participants, 467 persons were diagnosed with dementia including 292 AD and 105 VaD cases, and an additional 170 individuals were diagnosed as having questionable dementia. Diabetes was identified in 1424 subjects. In GEE models for all twins, diabetes was related to an adjusted OR (95% CI) of 1.89 (1.51–2.38) for dementia, 1.69 (1.16–2.36) for AD, and 2.17 (1.36–3.47) for VaD. The risk of dementia was higher in patients with diabetes onset before 65 years than in patients with diabetes onset age after 65 years. Conditional logistic analysis of 210 dementia-discordant co-twin pairs led to OR of 2.41 (1.05–5.51) for dementia related to midlife diabetes, and 0.68 (0.30–1.53) for dementia related to late-life diabetes. We confirm the association between diabetes and an increased risk of both AD and VaD. The risk effect seems to be stronger in people with diabetes onset at midlife than in people with diabetes onset in late life. Genetic and environmental factors in early life might account for the association between late life diabetes and dementia, but could not completely explain the midlife diabetes-dementia association.
Stereotaxic Frame and Computer Software for CT-directed Neurosurgical Localization (1980)

A clinical stereotaxic head frame designed for use with computed tomography (CT) body scanners is described. Frame geometry and a CT localization system provide an accuracy and versatility that should lead to optimal clinical usefulness. Initial phantom and clinical studies are presented.
Variables predictoras de los resultados de un programa de prevención secundaria de la depresión (2007)

On this study, predictors of efficacy, effectiveness and eficiency of three depression secondary prevention interventions were analysed: Cognitive-behavioral psychotherapy, reinforcing personal resources and social support. The sample was composed by 60 people with from-mild-to-moderate depression, who were randomly assigned either to any of the treatments or to a forth control group (waiting list). The interventions were developed in groups set at Primary Care Centres. Sociodemographic, psychopathology, quality of life and attendance to mental health services variables were assessed at pretest, postest and two follow-up evaluations, 6 and 12 months afterwards. These treatments have more efficacy on people in the middle of the psychopathological severity ranking, with symptoms mixed with anxiety, with a recent depression, with good social integration, with social support and without depression
troubles in the past.
Throughput improvement through dynamic load balance (2002)

Dynamic load balance improves the performance of a multiprocessor system by reallocating tasks such that all the processors are evenly loaded. Problems in several areas qualify for dynamic load balance. The paper studies the performance of load balancing while solving a branch and bound problem using hypercubes. If the hypercube has link faults, special measures need to be taken to balance the load. An algorithm for load balancing in the presence of link faults is described. Performance improvement obtained with the help of load balancing using the link-fault-tolerant algorithm is observed through simulation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effect of Lithium Iodide Addition on Poly(ethylene oxide)−Poly(vinylidene fluoride) Polymer-Blend Electrolyte for Dye-Sensitized Nanocrystalline Solar Cell (2008)

The effect of lithium iodide concentration on the conduction behavior of poly(ethylene oxide)-poly(vinylidene fluoride) (PEO-PVDF) polymer-blend electrolyte and the corresponding performance of the dye-sensitized solar cell (DSSC) were studied. The conduction behavior of these electrolytes was investigated with varying LiI concentration (10-60 wt % in polymer blend) by impedance spectroscopy. A "polymer-in-salt" like conduction behavior has been observed in the high salt concentration region. The transition from "salt-in-polymer" to "polymer-in-salt" conduction behavior happened at the salt content of 23.4 wt %, which is much lower than 50 wt % as generally reported. The electrolyte shows the highest ionic conductivity (approximately 10(-3) S cm(-1)) at the salt concentration above 23.4 wt %. From the evaluation of salt effect on the performances of corresponding DSSC, we find that increasing LiI concentration leads to increased short-circuit photocurrent density (Jsc) caused by enhanced I3(-) diffusion up to an LiI content of 28.9 wt %. Above this limitation, the Jsc decreases as a result of increased charge recombination caused by the further increased I3(-) concentration. The open-circuit voltage (Voc) increases gradually with LiI concentration owing to the enhanced I(-) content in DSSC. The optimized conversion efficiency is obtained at a salt content of 28.9 wt % in the "polymer-in-salt" region, with high ionic conductivity (1.06 x 10(-3) S cm(-1)). Based on these facts, we suggest that the changes of conduction behavior and the changes of I3(-) and I(-) concentrations in the electrolytes contribute to the final performance variation of the corresponding DSSC with varying LiI concentration.