gebhart/patrepeval huggingface dataset:
Human Papillomavirus Genotype Specificity of Hybrid Capture 2 (2008)

Hybrid Capture 2 (hc2), a clinical test for carcinogenic human papillomavirus (HPV) DNA, has proven to be a sensitive but only modestly specific predictor of cervical precancer and cancer risk. Some of its nonspecificity for clinical end points can be ascribed to cross-reactivity with noncarcinogenic HPV genotypes. However, the reference genotyping tests that have been used for these comparisons are also imperfect. We therefore sought to describe further the HPV genotype specificity of hc2 by comparing the hc2 results to paired results from two related PGMY09/11 L1 primer-based HPV genotyping assays: Linear Array (LA) and its prototype predecessor, the line blot assay (LBA). LA and LBA results were considered separately and combined (detection by either assay or both assays) for 37 individual HPV genotypes and HPV risk group categories (carcinogenic HPV > noncarcinogenic HPV > negative). Baseline specimens from 3,179 of 3,488 (91.5%) women referred to ALTS (a clinical trial to evaluate the management strategies for women with atypical squamous cells of undetermined significance [ASCUS] or low-grade squamous intraepithelial lesions) because of an ASCUS Papanicolaou smear were tested by all three assays. Among single-genotype infections with genotypes targeted by hc2 as detected by either PCR assay, HPV genotype 35 (HPV35) (86.4%), HPV56 (84.2%), and HPV58 (76.9%) were the most likely to test positive by hc2. Among single-genotype infections with genotypes not targeted by hc2 as detected by either assay, HPV82 (80.0%), HPV66 (60.0%) (recently classified as carcinogenic), HPV70 (59.1%), and HPV67 (56.3%) were the most likely to test positive by hc2. Among women who tested negative for carcinogenic HPV by both PCR tests and were positive for noncarcinogenic HPV by either test, 28% of women were hc2 positive. Conversely, 7.8% of all hc2-positive results in this population were due to cross-reactivity of hc2 with untargeted, noncarcinogenic HPV genotypes. In conclusion, hc2 cross-reacts with certain untargeted, noncarcinogenic HPV genotypes that are phylogenetically related to the targeted genotypes, but the degree of cross-reactivity may be less than previously reported.
Safety and efficacy of nabumetone in osteoarthritis: emphasis on gastrointestinal safety (2000)

The results suggest that nabumetone was similar in efficacy by most criteria to diclofenac SR and piroxicam in relieving the symptoms of osteoarthritis; however, nabumetone's GI safety profile was generally superior to that of both comparator NSAIDs. In the pooled analysis, nabumetone was associated with a significantly lower total incidence of ulcers and bleeding events, and a significantly lower incidence of complications associated with these events.
Rapid Migration of<sup>111</sup>Indium-Labeled Granulocytes to Sites of Infection (1981)

ISOTOPIC labels attached to various blood cells have been used for years to study the course and kinetics of blood components in vivo. The use of such labeling in granulocytes to evaluate transfusions or to localize infections has met with uncertain success.1 2 3 4 5 6 7 Recently, 111In combined with the chelating agent 8-hydroxyquinoline (oxine) has been used in granulocyte-labeling research.8 9 10 The advantages of 111In include tight cytoplasmic binding with minimal in vivo elution and preservation of cell viability and function after the granulocytes are exposed to the isotope.11 In addition, the energy spectrum of this element consists of two peaks at 173 and . . .
An algorithm for obtaining coefficients of bandpass functions from low-pass functions (1987)

An algorithm based on the Binomial Theorem is presented for calculating the coefficients of a continuous-time bandpass transfer function, obtained from a known low-pass prototype. The method is more general than a recently described method, provides more accurate results, and is insensitive to the choice of scaling factor.
Low Levels of Follicle-Stimulating Hormone Receptor-Activation Inhibitors in Serum and Follicular Fluid from Normal Controls and Anovulatory Patients with or without Polycystic Ovary Syndrome (1997)

In patients with normogonadotropic anovulation, either with or without polycystic ovary syndrome (PCOS), factors interfering with FSH action may be involved in arrested follicle development.The aim of this study is to assess whether factors inhibiting FSH receptor activation are elevated in serum or follicular fluid from anovulatory patients, as compared with regularly cycling women.For this purpose, a Chinese hamster ovary cell line, stably transfected with the human FSH receptor, has been applied.FSH-stimulated cAMP secretion in culture medium was measured in the presence of serum or follicular fluid.Chinese hamster ovary cells were stimulated with a fixed concentration of FSH (3 or 6 mIU/mL) to mimic FSH levels in serum or follicular fluid.Samples were added in concentrations ranging from 3-90% vol/vol to approach protein concentrations occurring in serum or follicular fluid.In the presence of 10% vol/vol serum from regularly cycling women (n ϭ 8), FSH-stimulated cAMP production was inhibited to 42 Ϯ 2% (mean Ϯ SEM of 2 experiments, each performed in duplicate) of cAMP production in the absence of serum, whereas a similar cAMP level (up to 38 Ϯ 4% of the serum-free level) was observed at higher concentrations of serum (30 -90% vol/vol).The inhibition of FSH-stimulated cAMP production in the presence of serum samples from normogo-
Tomography and its role in Quantum Computation (2001)

Quantum computation depends on quantum entanglement, a correlation between subsystems that cannot occur classically. A variety of theoretical measures exist for quantifying the degree entanglement in such schemes, all of which are functions of the system density matrix. How can the entanglement be measured experimentally? Using quantum tomography techniques developed for two photon entangled states, the density matrix can be reconstructed from the appropriate experimental data. In this case the state tomography gives the complete characterization of the physical system (for the relevant degree of freedom, such as spin or polarization). It gives information on both the degree of nonclassical correlation, that is entanglement, as well as the amount of decoherence in the system. In this proceedings we discuss the general state tomography procedure required to characterize a few qubit quantum computer, for any architecture.
Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non‐human primates (2014)

Targeting antigens to dendritic cell (DC) surface receptors using antibodies has been successfully used to generate strong immune responses and is currently in clinical trials for cancer immunotherapy. Whilst cancer immunotherapy focuses on the induction of CD8(+) T-cell responses, many successful vaccines to pathogens or their toxins utilize humoral immunity as the primary effector mechanism. Universally, these approaches have used adjuvants or pathogen material that augment humoral responses. However, adjuvants are associated with safety issues. One approach, successfully used in the mouse, to generate strong humoral responses in the absence of adjuvant is to target antigen to Clec9A, also known as DNGR-1, a receptor on CD8α(+) DCs. Here, we address two issues relating to clinical application. First, we address the issue of variable adjuvant-dependence for different antibodies targeting mouse Clec9A. We show that multiple sites on Clec9A can be successfully targeted, but that strong in vivo binding and provision of suitable helper T cell determinants was essential for efficacy. Second, we show that induction of humoral immunity to CLEC9A-targeted antigens is extremely effective in nonhuman primates, in an adjuvant-free setting. Our findings support extending this vaccination approach to humans and offer important insights into targeting design.
Regulation of juvenile hormone esterase gene transcription by juvenile hormone (1994)

Juvenile hormone (JH) is a major hormone regulating insect development. We have obtained a cDNA and a genomic clone for juvenile hormone esterase (JHE), the enzyme that is involved in the degradation of juvenile hormone and which is critical for insect development. Analysis of the regulation of JHE during the final larval stadium in the cabbage looper, Trichoplusia ni, showed that the JHE mRNA levels are maximal on days 2 and 4 of the final stadium. Nuclear run-on analyses demonstrated that changes in JHE mRNA levels are primarily due to changes in the transcription rate of the gene, which may be a single copy in the genome. Treatment with a JH analog resulted in induction of JHE gene transcription, which could be detected within three hours after treatment. Salient features present in the 5' flanking region of this JH-sensitive gene are presented, including the presence of sequences closely resembling binding sites for members of the family of nuclear receptors. This report is the first direct demonstration, by nuclear run-on analysis, of JH induction of gene transcription.
Neuromorphic Analog Implementation of Neural Engineering Framework-Inspired Spiking Neuron for High-Dimensional Representation (2021)

Brain-inspired hardware designs realize neural principles in electronics to provide high-performing, energy-efficient frameworks for artificial intelligence. The Neural Engineering Framework (NEF) brings forth a theoretical framework for representing high-dimensional mathematical constructs with spiking neurons to implement functional large-scale neural networks. Here, we present OZ, a programable analog implementation of NEF-inspired spiking neurons. OZ neurons can be dynamically programmed to feature varying high-dimensional response curves with positive and negative encoders for a neuromorphic distributed representation of normalized input data. Our hardware design demonstrates full correspondence with NEF across firing rates, encoding vectors, and intercepts. OZ neurons can be independently configured in real-time to allow efficient spanning of a representation space, thus using fewer neurons and therefore less power for neuromorphic data representation.
Trends in Copper Precursor Development for CVD and ALD Applications (2014)

The continued dominance of copper in microelectronic manufacturing is due in part to the techniques that have kept pace with the relentless trend towards smaller feature sizes. Pure and defect-free copper features can be created at these and smaller scales using gas phase deposition methods such as chemical vapor deposition (CVD) and atomic layer deposition (ALD). Here we review the deposition processes and in particular surface chemistry for depositing copper metal by CVD and ALD. A summary of known processes is given, and new trends in copper film deposition research are discussed. As well, process parameters and properties of copper films deposited from precursors using key ligand systems such as aminoalkoxides, amidinates, guanidinates, betadiketonates and betaketoiminates are presented. Surface chemistry is examined from the point of view of the similarities of CVD and ALD, considering precursors that can be used in both types of processes. This serves to highlight trends in decomposition mechanisms and illuminates some interesting similarities in process temperature and other parameters.
Diazadiene als Steuerliganden in der homogenen Katalyse, IX. Katalytische Cyclotetramerisierung von Propiolsäureestern (1985)

Abstract Propiolsäureester HCCCO 2 R 2 lassen sich bei niedriger Temperatur in Cyclohexan an Präkatalysatoren vom Typ der Diazadien‐Nickel(0)‐Komplexe 3 bzw. 4 oder an Diazadien‐Nickel‐(η 2 ‐Alkin)‐Komplexen wie 5b vollständig oder überwiegend zu Cyclooctatetraen‐tetracarbon‐säureestern 7 umsetzen. Aus 1 H‐ und 13 C‐NMR‐Daten sowie mit chemischen Methoden ergibt sich ein 1,3,6,8‐Substitutionsmuster (Symmetrie C 2 ).
Studies in Organic Peroxides. VI. Cyclane Peroxides (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies in Organic Peroxides. VI. Cyclane PeroxidesNicholas A. Milas, S. Arthur. Harris, and Paul C. PanagiotakosCite this: J. Am. Chem. Soc. 1939, 61, 9, 2430–2432Publication Date (Print):September 1, 1939Publication History Published online1 May 2002Published inissue 1 September 1939https://pubs.acs.org/doi/10.1021/ja01878a048https://doi.org/10.1021/ja01878a048research-articleACS PublicationsRequest reuse permissionsArticle Views163Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lung Angiogenesis Requires CD4+Forkhead Homeobox Protein-3+ Regulatory T Cells (2014)

Angiogenesis in ischemic organs is modulated by immune cells. Systemic neovascularization of the ischemic lung requires macrophages, with chemokines playing a central role in new vessel growth. Because regulatory T (Treg) cells modulate tumor-induced neovascularization, we questioned whether this CD4(+) lymphocyte subset impacts blood vessel growth during ischemia. In a model of left lung ischemia, an increase in CD4(+) CD25(+) forkhead homeobox protein-3 (Foxp3)(+) cells was observed 3-5 days after the onset of ischemia in wild-type C57Bl/6 mice. Using transgenic mice where Foxp3(+) Treg cells can be depleted with diphtheria toxin (DT; Foxp3(DTR)), we unexpectedly found that Foxp3(+) Treg depletion led to markedly reduced lung angiogenesis (90% reduction from Foxp3(gfp) controls). Adoptive transfer studies using CD4(+) CD25(+) splenocytes from congenic CD45.1 mice into Foxp3(+) Treg-depleted mice showed an almost complete recovery of the angiogenic phenotype (80% of Foxp3(gfp) controls). A survey of lung gene expression of angiogenic (lipopolysaccharide-induced CXC chemokine [LIX], IL-6, IL-17) and angiostatic (IFN-γ, transforming growth factor-β, IL-10) cytokines showed Treg-dependent differences only in LIX (CXCL5) and IL-6. Protein confirmation demonstrated a significant reduction in LIX in Treg-deficient mice compared with controls 5 days after the onset of ischemia. Phenotyping other inflammatory cells in the lung by multicolor flow cytometry demonstrated a significantly reduced number of macrophages (major histocombatibility complex class II [MHCII](int), CD11C(+)) in Treg-deficient lungs compared with Treg-sufficient lungs. Treg cells are essential for maximal systemic angiogenesis after pulmonary ischemia. One likely mechanism responsible for the decrease in angiogenesis in Treg-depleted mice was the decline in the essential CXC chemokine, LIX.
Current-induced defect conductivity in hydrogenated silicon-rich amorphous silicon nitride (1995)

Abstract In general, current transport through thin-film metal-semiconductor-metal diodes containing hydrogenated silicon-rich amorphous silicon nitride (a-SiNx: H) is determined by electron tunnelling through the potential barriers at the metal-semiconductor contacts. After prolonged current stressing, however, there is a change in the transport mechanism and a large increase in the current. It is shown that the excess current flow is well described by field-enhanced emission of carriers via charged defect states throughout the bulk of the silicon nitride. The effect of the electric field and dependence on defect concentration is consistent with the transport of holes in the vicinity of the valence band tail. As stressing proceeds, more defect states are introduced and the conductivity of the a-SiNx:H increases.
Compreensão de textos e desempenho acadêmico (2006)

The comprehension ability of reading in the higher education can be the difference between a quality scientific technical learning or not. This research aimed to explore the relation between the reading comprehension and the academic performance, considering the age and gender of the students. The sample was composed of 270 undergraduates of the administration, law and psychology courses, attending at a private university of the Sao Paulo State. They aged in average 23 years and 6 months, and collectively answered a text of 250 words, organized according the test of Cloze, in its traditional version. The results showed a significant association between reading comprehension and performance in relation to the course, the age and gender. Keyswords: Cloze’s Technique; reading; university.
Disinfection of Surgical Wounds Without Inhibition of Normal Wound Healing (1980)

The goal of disinfection of surgical wounds is to destroy as large a number as possible of the microbes that have made their way into the surgical wounds during the time of surgery, without disturbing the normal wound-healing process. It is not a substitute for preoperative disinfection of the skin or aseptic technique, but makes it possible to further decrease the rate of infection in slightly or moderately contaminated wounds. This was shown with a series of 294 pediatric surgical patients, 283 of whom had undergone appendectomy. A 5% povidone-iodine solution, especially in combination with excipients, was too strong, whereas a 1% povidone-iodine solution without excipients applied to the surgical wound was safe from the standpoint of wound healing, and decresed the number of wound infections in those patients with appendicitis in whom neither peritonitis nor periappendicular abscess had yet developed.
Emerson in Contemporary Thought (1988)

Analyse de l'idealisme du philosophe americain Emerson, compris moins comme une theorie raisonnee sur le monde que comme une conviction verifiee au travers de l'experience ordinaire dans laquelle Emerson nous demande de rechercher le sens et la valeur sans nous arreter aux faits
Distributional notes and new records of Acmaeodera (Coleoptera, Buprestidae) (1941)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
PIP<sub>2</sub>and Proteins: Interactions, Organization, and Information Flow (2002)

We review the physical properties of phosphatidylinositol 4,5-bisphosphate (PIP2) that determine both its specific interactions with protein domains of known structure and its nonspecific electrostatic sequestration by unstructured domains. Several investigators have postulated the existence of distinct pools of PIP2 within the cell to account for the myriad functions of this lipid. Recent experimental work indicates certain regions of the plasma membrane-membrane ruffles and nascent phagosomes-do indeed concentrate PIP2. We consider two mechanisms that could account for this phenomenon: local synthesis and electrostatic sequestration. We conclude by considering the hypothesis that proteins such as MARCKS bind a significant fraction of the PIP2 in a cell, helping to sequester it in lateral membrane domains, then release this lipid in response to local signals such as an increased concentration of Ca(++)/calmodulin or activation of protein kinase C.
Present status of the efficacy and tolerability of terbinafine (Lamisil) used systemically in the treatment of dermatomycoses of skin and nails (1990)

Lamid is a new antifungal drug which can be administered orrally and is effective against a broad range of dermatomycoses. This report summarizes its mycological and clinical cure rates in 32 clinical studies in which it was used orally for the treatment of tinea corporis, tinea pedis (both interdigital and plantar types), onychomycosis of fingernails and toenails, cutaneous candidiasis and pityriasis versicolor. The pharmacokinetic profile shows Lamisil to be distributed extensively into lipophilic tissue and to have an elimination half-life from plasma which allows effective oncedaily administration. It diffuses from the vascular system into the stratum corneum where it binds, reaching levels well above the fungicidal concentrations against dermatophytes and yeast. In the treatment of over 1000 patients it has been shown to be very effective, leading to clinical cure in all the dermatomycoses listed above except pityriasis versicolor. It was particularly, and uniquely, effective in the most chronic forms of tinea pedis and onychomycosis. Lamisil is well tolerated, with only mild to moderate transient gastrointestinal side effects such as fullness, dyspepsia or nausea in a few patients. None of the hepatic or endocrine effects seen with imidazoles has been observed. Animal toxicology issues are reviewed. Lamisil meets a need for a new class of antifungal drug which is well tolerated, has rapid onset of action, can be used for short durations of therapy, is fungicidal and is active against chronic, resistant forms of dermatophyte infections of skin and nails.
Preliminary investigation of micropumping based on electrical control of interfacial tension (2002)

Electrical control of the interfacial tension between a liquid and solid (electrowetting) is studied as a means of microactuation for fluid systems, i.e. micropumping Electrowetting provides a means of direct fluid pumping with no moving mechanical parts, which may prove useful in a number of application areas, such as micro chemical dispensers, injectors, and reactors, and even cooling systems for high-density microelectronics. A test device has been built (with silicon micromachining) for the study of electrowetting, and a detailed model of the devices is given. The model describes liquid flow in a small channel, as governed by Navier-Stokes equations, Laplace's equation, Young's equation, and Lippmann's equation. Simulation results presented indicate that electrowetting is a viable approach to microactuation: in a 10 mu m radius channel, it may be used to generate pressures on the order of 0.01 MPa, comparable to pressures generated by existing micropump designs are order of magnitude larger in size. Although the dynamics of the test device are dominated by fluid friction, it is also shown that another micropump design, based on mercury, should behave as a nearly frictionless oscillator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Prediction Of Bath Temperature Using Neural Networks (2008)

In this work, we consider an application of neural networks in LD converter. Application of this approach assumes a reliable prediction of steel temperature and reduces a reblow ratio in steel work. It has been applied a conventional model to charge calculation, the obtained results by this technique are not always good, this is due to the process complexity. Difficulties are mainly generated by the noisy measurement and the process non linearities. Artificial Neural Networks (ANNs) have become a powerful tool for these complex applications. It is used a backpropagation algorithm to learn the neural nets. (ANNs) is used to predict the steel bath temperature in oxygen converter process for the end condition. This model has 11 inputs process variables and one output. The model was tested in steel work, the obtained results by neural approach are better than the conventional model.