gebhart/patrepeval huggingface dataset:
Aldosterone impairs baroreflex sensitivity in healthy adults (2006)

Animal studies suggest that acute and chronic aldosterone administration impairs baroreceptor/baroreflex responses. We tested the hypothesis that aldosterone impairs baroreflex control of cardiac period [cardiovagal baroreflex sensitivity (BRS)] and muscle sympathetic nerve activity (MSNA, sympathetic BRS) in humans. Twenty-six young (25 +/- 1 yr old, mean +/- SE) adults were examined in this study. BRS was determined by using the modified Oxford technique (bolus infusion of nitroprusside, followed 60 s later by bolus infusion of phenylephrine) in triplicate before (Pre) and 30-min after (Post) beginning aldosterone (experimental, 12 pmol.kg(-1).min(-1); n = 10 subjects) or saline infusion (control; n = 10). BRS was quantified from the R-R interval-systolic blood pressure (BP) (cardiovagal BRS) and MSNA-diastolic BP (sympathetic BRS) relations. Aldosterone infusion increased serum aldosterone levels approximately fourfold (P < 0.05) and decreased (P < 0.05) cardiovagal (19.0 +/- 2.3 vs. 15.6 +/- 1.7 ms/mmHg Pre and Post, respectively) and sympathetic BRS [-4.4 +/- 0.4 vs. -3.0 +/- 0.4 arbitrary units (AU).beat(-1).mmHg(-1)]. In contrast, neither cardiovagal (19.3 +/- 3.3 vs. 20.2 +/- 3.3 ms/mmHg) nor sympathetic BRS (-3.8 +/- 0.5 vs. -3.6 +/- 0.5 AU.beat(-1).mmHg(-1)) were altered (Pre vs. Post) in the control group. BP, heart rate, and MSNA at rest were similar in experimental and control subjects before and after the intervention. Additionally, neural and cardiovascular responses to a cold pressor test and isometric handgrip to fatigue were unaffected by aldosterone infusion (n = 6 subjects). These data provide direct experimental support for the concept that aldosterone impairs baroreflex function (cardiovagal and sympathetic BRS) in humans. Therefore, aldosterone may be an important determinant/modulator of baroreflex function in humans.
Review of dentinal bonding in vitro: the substrate. (1990)

This article reviews common substrates and testing conditions used in dentinal bond strength studies in vitro. The available literature supports the use of freshly extracted, hydrated human teeth for studies in vitro. No one testing condition has proven superior accuracy over the others. Evidence is presented to support the implementation of infection control measures when handling the substrates.
Correlation via synthesis: end-to-end nodule image generation and radiogenomic map learning based on generative adversarial network (2019)

Radiogenomic map linking image features and gene expression profiles is useful for noninvasively identifying molecular properties of a particular type of disease. Conventionally, such map is produced in three separate steps: 1) gene-clustering to "metagenes", 2) image feature extraction, and 3) statistical correlation between metagenes and image features. Each step is independently performed and relies on arbitrary measurements. In this work, we investigate the potential of an end-to-end method fusing gene data with image features to generate synthetic image and learn radiogenomic map simultaneously. To achieve this goal, we develop a generative adversarial network (GAN) conditioned on both background images and gene expression profiles, synthesizing the corresponding image. Image and gene features are fused at different scales to ensure the realism and quality of the synthesized image. We tested our method on non-small cell lung cancer (NSCLC) dataset. Results demonstrate that the proposed method produces realistic synthetic images, and provides a promising way to find gene-image relationship in a holistic end-to-end manner.
Effects of growth hormone and IGF-I on renal function in rats with normal and reduced renal mass (1990)

To characterize actions of growth hormone (GH) and insulin-like growth factor ( (IGF-I) on renal function in rats with normal and reduced renal mass, we administered recombinant bovine growth hormone (bGH) or human IGF-I (hIGF-I) to normal rats or to rats that had undergone unilateral nephrectomy and two-thirds infarction of the contralateral kidney, and measured inulin and p-aminohippurate clearances over 10-17 days. Administration of either bGH (100-200 micrograms/day) or hIGF-I (200 micrograms/day) to rats with normal renal mass increased inulin and p-aminohippurate clearances compared with those measured in animals that received vehicle. Filtration fractions were not affected by either bGH or hIGF-I. Inulin clearance was decreased to approximately 17% of normal 1 day after reduction of renal mass in rats. Over the next 3 days insulin clearance increased significantly in rats with reduced renal mass that were administered vehicle. No further enhancement occurred during the next 7 days. Neither bGH nor hIGF-I affected inulin clearance in rats with reduced renal mass. We conclude that both GH and IGF-I enhance glomerular filtration rate when administered to rats with normal renal mass, but not when administered in the same quantities to rats in which renal functional mass is reduced. Glomerular filtration rate increases within 4 days of renal mass reduction independent of exogenous GH or IGF-I.
Design of dual-band dual-polarized wire antennas using a genetic algorithm (2003)

A new dual-band polarization-agile wire antenna element is presented along with a method of tuning the resonant frequency, impedance, and radiation pattern of the antenna. The four terminal antenna can radiate in one of two modes: dipole mode or slot mode. Ideally, the radiation patterns and resonant frequencies of the two modes are identical and their polarizations are orthogonal in every direction. Superposition of the two modes will allow for the synthesis of any linear, circular, or elliptical polarization, and identical mode radiation patterns and orthogonal mode polarizations will allow for synthesis of any polarization in any direction. This polarization synthesis capability makes the polarization-agile wire antenna element a natural for inclusion in smart antenna systems. The resonant frequencies, impedance, and radiation patterns of the antenna are tuned through additional wires that may be thought of as integrated tuning stubs. These tuning stubs will allow the polarization-agile wire antenna to radiate each mode effectively at multiple specified frequencies. Genetic algorithm optimization techniques have been used in the development of the polarization-agile multiple-resonant wire antenna with impedance-matched resonant frequencies of 30 and 45 MHz for both the slot and dipole modes.
3D Microscopy and Microanalysis of Heterogeneous SEM Samples by Broad Ion Beam Processing: Cutting - Etching - Coating (2002)

Journal Article 3D Microscopy and Microanalysis of Heterogeneous SEM Samples by Broad Ion Beam Processing: Cutting - Etching - Coating Get access W Hauffe, W Hauffe Physics Department, Dresden University of Technology, D-01062 Dresden, Germany Search for other works by this author on: Oxford Academic Google Scholar D Glöß, D Glöß Physics Department, Dresden University of Technology, D-01062 Dresden, Germany Search for other works by this author on: Oxford Academic Google Scholar RJ Mitro RJ Mitro Gatan R&D, 5933 Coronado Lane, Pleasanton, CA 94588, USA Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 8, Issue S02, 1 August 2002, Pages 552–553, https://doi.org/10.1017/S1431927602105435 Published: 01 August 2002
mSLP-mesh-enhanced service location protocol (2002)

The service location protocol (SLP), a proposed IETF standard, provides a flexible and scalable service discovery framework for IP networks. It can be deployed with or without a directory service. This paper presents mSLP, the mesh-enhanced service location protocol. mSLP enhances SLP with a fully-meshed peer directory agent (DA) architecture. Peer DAs exchange service registration information, and maintain the same consistent data for shared scopes. mSLP improves the reliability and consistency of SLP directory services. It also greatly simplifies service agent (SA) registrations in systems with multiple DAs. mSLP is backward compatible with SLPv2 and can be deployed incrementally.
Studies on the preparation of new magnetic polyolefins using nanometer magnetic Ziegler-Natta catalyst (1999)

Nanometer magnetic particles were prepared through oxidizing Fe2+ in basic solution. Initially, using resultant nanometer magnetic powder as support, supported nanometer magnetic Ziegler–Natta catalysts were obtained. Through polymerization in situ on the surface of nanometer magnetic particles, a new kind of magnetic polyolefin that is different from both the composite plastics' magnet and the structure plastics' magnet was obtained. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 71: 2087–2090, 1999
Increased calcium levels alter cellular and molecular events in wound healing. (1989)

Surgical morbidity is dictated directly by wound healing. We have studied the effects of elevated calcium levels using cultured keratinocytes in vitro on two of the rate-limiting steps of wound healing, chemotaxis (directed migration) and adhesion. We found that the increased calcium (10 mmol/L) significantly inhibited both keratinocyte chemotaxis and adhesion (p less than 0.05). The calcium effect on adhesion could be partially reversed by pretreatment with the calcium channel blocker verapamil. Based on these data, an animal model was formulated in which topical calcium (5 mmol/L/day) was added to linear incision wounds. This resulted in significantly (p less than 0.05) delayed wound contraction characteristic of a chronic or impaired wound. Wound contraction depends on the presence of fibroblasts that synthesize collagen. The chronic wound was characterized by increased collagenase activity (p less than 0.05) but little alteration in collagen I synthesis. The addition of verapamil to these chronic wounds resulted in improved wound closure. These studies define the molecular and cellular events occurring as a result of the addition of elevated levels of calcium both in vitro and in vivo. Calcium may play a key role in the pathogenesis of chronic wounds.
[67kDa-laminin receptor in human lung cancer]. (1992)

Complimentary DNA for the 67kDa-laminin receptor was cloned from the cDNA library derived from a human lung cancer cell line, and the nucleotide sequence was determined. Expression of the gene was estimated by Northern analysis in various types of human lung cancer. As a result, increased expression of the laminin receptor was demonstrated especially in the cell types of small cell cancer and bronchioloalveolar cell cancer, which are aggressive biologically. Antibody raised against a partial sequence of the polypeptide was prepared for immunodetection of 67kDa-laminin receptor. It was shown that immunohistochemistry with the antibody could be applied to diagnostic use in lung cancer. The results also suggest that the laminin receptor polypeptide is not necessarily a membrane-associated protein and may function without further processing to the receptor.
Iron-containing superoxide dismutase from Crithidia fasciculata. Purification, characterization, and similarity to Leishmanial and trypanosomal enzymes. (1983)

Leishmania tropica, Trypanosoma brucei, Trypanosoma cruzi, and Crithidia fasciculata have superoxide dismutases which are insensitive to cyanide and sensitive to peroxide and azide, properties characteristic of iron-containing superoxide dismutase. Studies on the superoxide dismutase of C. fasciculata have revealed that: 1) the enzyme is located in the cytosol; 2) isozymes exist; 3) the major superoxide dismutase isozyme (superoxide dismutase 2) has Mr approximately equal to 43,000 and consists of two equal-sized subunits, each of which contains 1.4 atoms of iron. Comparisons of the amino acid content of this crithidial superoxide dismutase with those of superoxide dismutases from other sources suggests that the crithidial enzyme is closely related to bacterial Fe-containing superoxide dismutases, and only distantly related to human Mn- and Cu,Zn-containing superoxide dismutases and to Euglena Fe-containing superoxide dismutase. Attempts are now underway to develop specific inhibitors of the trypanosomatid superoxide dismutase which may be of use in the treatment of leishmaniasis or trypanosomiasis.
Interaction between Borrelia burgdorferi and endothelium in vitro. (1990)

During the pathogenesis of Lyme disease, Borrelia burgdorferi spreads hematogenously from the site of a tick bite to several tissues throughout the body. The specific mechanism of spirochete emigration is presently unknown. Using cultured human umbilical vein endothelial cells, we found that Borrelia burgdorferi bound to the endothelial cells and to the subendothelial matrix. Low passage isolates adhered 22-30-fold greater than a strain maintained in culture continuously. Spirochete binding to subendothelial matrix was inhibited 48-63% by pretreatment of the matrix with anti-fibronectin antiserum. Spirochete migration across endothelial monolayers cultured on amniotic membrane was increased when the monolayers were damaged by chemical or physical means. Electron microscopic examination of spirochete-endothelial interactions demonstrated the presence of spirochetes in the intercellular junctions between endothelial cells as well as beneath the monolayers. Scanning electron microscopy identified a mechanism of transendothelial migration whereby spirochetes pass between cells into the amniotic membrane at areas where subendothelium is exposed.
Clinical review of twenty-five cases of orbital neurofibromas (2008)

Objective To evalulate the clinical features,diagnosis and treatment of orbital neurofibromas.Methods The medical records of 25 patients with orbital neurofibromas visited between May of 1995 and July of 2006 in Zhongshan Ophthalmic Center of Sun Yat-sen University were retrospectively reviewed.Results In the group of patients with their age of less than or equal to 10 years old,89.5%of them are plexiform neurofibromas,63.2%of them belong to type Ⅰ neurofibromatosis with 10.5%having positive family history,10.5% of them have congenital glaucoma.Frequently,most of them have typical cafe an lair spots,Lisch nodules(Iris hamartomas)and so on.It is not difficult to make a correct presurgical diagnosis.However,surgical excision is troublesome with a high rate of recurrence.In the group of patients with their age of more than 10 years old,Most of them have isolated neurofibromas.Their clinical features are similar to those of other orbital benign tumors,however,They often show a low to moderate,occasionally even a negative hounsfield value on CT scan.It is not easy to make a correct presurgical diagnosis.The mass can often be removed completely with a low rate of recurrence.Conclusion Orbital neurofibromas occur more often in patients with their age younger than ten years old.Most of them are plexiform neurofibromas with various clinical manifestations.It is easy to make a clinical diagnosis,however,surgical treatment is troublesome with a high rate of recurrence.

Key words: 
Neurofibromas; Orbit; diagnosis; Treatment; Imaging
A Social-Network-Based Cryptocurrency Wallet-Management Scheme (2018)

Effective cryptocurrency key management has become an urgent requirement for modern cryptocurrency. Although a large body of cryptocurrency wallet-management schemes has been proposed, they are mostly constructed for specific application scenarios and often suffer from weak security. In this paper, we propose a more effective, usable, and secure cryptocurrency wallet-management system based on semi-trusted social networks, therein allowing users to collaborate with involved parties to achieve some powerful functions and recovery under certain circumstances. Furthermore, we employ an identity-based hierarchical key-insulated encryption scheme to achieve time-sharing authorization and present a semi-trusted portable social-network-based wallet-management scheme that provides the features of security-enhanced storage, portable login on different devices, no-password authentication, flexible key delegation, and so on. The performance analysis shows that our proposed schemes require minimal additional overhead and have low time delays, making them sufficiently efficient for real-world deployment.
Potential anxiolytic‐ and antidepressant‐like effects of salvinorin A, the main active ingredient of <i>Salvia divinorum</i>, in rodents (2009)

The anxiolytic- and antidepressant-like effects of Salvinorin A are mediated by both kappa-opioid and endocannabinoid systems and may partly explain the subjective symptoms reported by recreational users of S. divinorum.
The N-linked oligosaccharide at Fc RIIIa Asn-45: an inhibitory element for high Fc RIIIa binding affinity to IgG glycoforms lacking core fucosylation (2008)

Human leukocyte receptor IIIa (Fc gamma RIIIa) plays an important role in mediating therapeutic antibodies' antibody-dependent cellular cytotoxicity (ADCC), which is closely related to the clinical efficacy of anticancer processes in humans in vivo. The removal of the core fucose from oligosaccharides attached to the Fc region of antibodies improves Fc gamma RIIIa binding, allowing the antibodies to enhance dramatically the antibody effector functions of ADCC. In this study, the contribution of Fc gamma RIIIa oligosaccharides to the strength of the Fc gamma RIIIa/antibody complex was analyzed using a serial set of soluble human recombinant Fc gamma RIIIa lacking the oligosaccharides. A nonfucosylated antibody IgG1 appeared to have a significantly higher affinity to the wild-type Fc gamma RIIIa fully glycosylated at its five N-linked oligosaccharide sites than did the fucosylated IgG1, and this increased binding was almost abolished once all of the Fc gamma RIIIa glycosylation was removed. Our gain-of-function analysis in the Fc gamma RIIIa oligosaccharide at Asn-162 (N-162) confirmed that N-162 is the element required for the high binding affinity to nonfucosylated antibodies, as previously revealed by loss-of-function analyses. Interestingly, beyond our expectation, the Fc gamma RIIIa modified by N-162 alone showed a significantly higher binding affinity to nonfucosylated IgG1 than did the wild-type Fc gamma RIIIa. Attachment of the other four oligosaccharides, especially the Fc gamma RIIIa oligosaccharide at Asn-45 (N-45), hindered the high binding affinity of Fc gamma RIIIa to nonfucosylated IgG1. Our data clearly demonstrated that N-45 is an inhibitory element for the high Fc gamma RIIIa binding affinity mediated by N-162 to nonfucosylated antibodies. This information can be exploited for the structural-based functional study of Fc gamma RIIIa.
Extremely high peak specific transconductance AlGaAs/GaAs heterojunction bipolar transistors (1989)

Self-aligned AlGaAs/GAs heterojunction bipolar transistors with peak specific transconductances as high as 25 mS/ mu m/sup 2/ of emitter area are discussed. These are the highest specific transconductances ever reported for a bipolar transistor. These devices, which contain no indium in the emitter, display specific parasitic emitter resistances of less than 1*10/sup -7/ Omega -cm/sup 2/. This low parasitic resistance is attributed to an improved n-type contact technology, in which a molybdenum diffusion barrier and a plasma-enhanced chemical vapor deposition SiO/sub 2/ overlayer are used to achieve low specific contact resistivities.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modification of Hydrophilic and Hydrophobic Surfaces Using an Ionic-Complementary Peptide (2007)

Ionic-complementary peptides are novel nano-biomaterials with a variety of biomedical applications including potential biosurface engineering. This study presents evidence that a model ionic-complementary peptide EAK16-II is capable of assembling/coating on hydrophilic mica as well as hydrophobic highly ordered pyrolytic graphite (HOPG) surfaces with different nano-patterns. EAK16-II forms randomly oriented nanofibers or nanofiber networks on mica, while ordered nanofibers parallel or oriented 60u or 120u to each other on HOPG, reflecting the crystallographic symmetry of graphite (0001). The density of coated nanofibers on both surfaces can be controlled by adjusting the peptide concentration and the contact time of the peptide solution with the surface. The coated EAK16-II nanofibers alter the wettability of the two surfaces differently: the water contact angle of bare mica surface is measured to be ,10u, while it increases to 20.362.9u upon 2 h modification of the surface using a 29 mM EAK16-II solution. In contrast, the water contact angle decreases significantly from 71.2611.1u to 39.464.3u after the HOPG surface is coated with a 29 mM peptide solution for 2 h. The stability of the EAK16-II nanofibers on both surfaces is further evaluated by immersing the surface into acidic and basic solutions and analyzing the changes in the nanofiber surface coverage. The EAK16-II nanofibers on mica remain stable in acidic solution but not in alkaline solution, while they are stable on the HOPG surface regardless of the solution pH. This work demonstrates the possibility of using self-assembling peptides for surface modification applications.
Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico (2004)

Bone morphogenetic proteins (BMPs) are implicated in the regulation of morphogenesis and proliferation during embryogenesis and carcinogenesis. We have previously reported over-expression of BMP4 in diffuse-type gastric cancer cells. BMP signaling is regulated by tissue-specific expression of ligands and receptors as well as by secreted-type antagonists, such as CKTSF1B1 (Gremlin), CER1 (Cerberus 1), Noggin, SOSTDC1 (Ectodin), and Chordin. Here, we identified two novel genes related to CKTSF1B1 and CER1 by using bioinformatics. Two novel members of human CKTSF1B gene family were designated CKTSF1B2 (GREM2 or PRDC) and CKTSF1B3 (GREM3 or DANTE). FLJ21195 (BC046632.1) was the representative human CKTSF1B2 cDNA, and CKTSF1B2 gene was mapped to human chromosome 1q43. Human CKTSF1B2 showed 94.0% total amino-acid identity with mouse Cktsf1b2 (Prdc). FLJ38607 (AK095926.1) was the representative human CKTSF1B3 cDNA, and CKTSF1B3 gene was mapped to human chromosome 19p13.2. Human CKTSF1B3 showed 61.9% total amino-acid identity with mouse Cktsf1b2 (Dante). N-terminal signal peptide and DAN domain with nine cysteine residues were conserved among CKTSF1B1, CKTSF1B2, CKTSF1B3 and CER1. Phylogenetic analyses revealed that CKTSF1B2 was more related to CKTSF1B1, and that CKTSF1B3 was more related to CER1. CKTSF1B1, CKTSF1B2, CKTSF1B3 and CER1 constitute the CKTSF1B family among secreted-type cysteine knot superfamily proteins. This is the first report on identification and characterization of the human CKTSF1B2 and CKTSF1B3 genes.
Current-perpendicular-to-the-plane giant magnetoresistance in structures with half-metal materials laminated between CoFe layers (2004)

A current-perpendicular-to-the-plane spin-valve (CPP-SV) structure having half-metal materials laminated between CoFe layers was investigated. A CPP-SV film having a CoMnGe free layer had a resistance-change-area product ΔRA of 0.9 mΩ μm2, almost the same as that of a CPP-SV film having a simple CoFe free layer. But the ΔRA of a CPP-SV film with a CoFe/CoMnGe/CoFe sandwiched free layer was 1.6 mΩ μm2. CPP-SV films having CoFe/iron-added-magnetite/CoFe sandwiched layers were also investigated and found to have a ΔRA of ≈2 mΩ μm2. We found that a CoFe/half-metal/CoFe sandwiched layer was a stronger source of spin-dependent scattering than a CoFe layer and simple half-metal layer.