gebhart/patrepeval huggingface dataset:
Travel Time Prediction for Urban Networks: the Comparisons of Simulation-based and Time-Series Models (2010)

Travel time prediction for urban networks is an important issue in Advanced Traveler Information Systems (ATIS) since drivers can make individual decisions, choose the shortest route, avoid congestion and improve network efficiency based on the predicted travel time information. In this research, two algorithms are proposed to estimate and predict travel time for urban networks: the simulation-based and time-series models. The simulation-based model, DynaTAIWAN, designed and developed for mixed traffic flows, is adopted to simulate the traffic flow patterns. The Autoregressive Integrated Moving Average (ARIMA) model, calibrated with vehicle detector (VD) data, is integrated with signal delay to predict travel time for arterial streets. In the numerical analysis, an arterial street in Kaohsiung city in Taiwan is conducted to illustrate these two models. The empirical and historical data are used to predict and analyze travel time, including: travel time data from survey and historical speed data from vehicle detectors (VD).
Ask the hard questions (2003)

For particular classes of problems that we can state as generalizations of finding the period of a discrete function or locating an item on a discrete list, quantum computing promises a dramatic speedup over classical machines. Quantum computing has had a stimulating effect on the theory of computing, generated some excellent thinking about the foundations of quantum mechanics, and justified some elegant experimental work in applied physics. But, as was probably inevitable, it also has generated some myths. I think the myths actually affect public perception of what's possible in computing technology and, by implication, can lead to wild overestimates of what to expect from computational science.
Powering networks on chips (2001)

We consider systems on chips (SoCs) that will be designed and produced in five to ten years from today, with gate lengths in the range 50-100nm. We address the distinguishing features of a design methodology that aims at achieving reliable designs under the limitations of the interconnect technology. Specifically, we consider energy consumption reduction, under guaranteed quality of service (QoS), as a main objective in system design.
Effector CD8+ T cells abrogate fibroblasts-mediated chemoresistance in ovarian cancer (TUM2P.1007) (2015)

Abstract Tumor infiltrating effector CD8+ T cells have been described to play a major role in antitumoral activity and to be a favorable prognostic factor in ovarian cancer. The strategies of immunotherapy to improve effector T cells response have also shown potential clinical benefit in subset of ovarian cancer patients. Currently platinum-based chemotherapy is still the most active regimen for ovarian cancer treatment. However, the therapeutic resistance is a major challenge to limit the therapeutic efficiency. Here we found primary fibroblasts isolated from ovarian tumor speciman could induce resistance against cisplatin in cancer cells when the two cell types were co-cultured in vitro or co-inoculated in vivo. Activated CD8+ T cells abolished fibroblasts-mediated cisplatin resistance through IFNγ secretion. Next, we found fibroblasts induced cisplatin resistance through increasing intracellular Glutathione (GSH) level and reducing the cisplatin accumulation in cancer cells. We also identified both intact GSH and Cysteine released by fibroblasts contributed to cisplatin resistance in cancer cells. IFNγ producted by activated CD8+ T cells promoted fibroblasts extracellular GSH degradation through up-regulation of Gamma-glutamyl transpeptidase, and also diminished Cysteine generation by fibroblasts through down-regulation of System xc⁻ cystine/glutamate antiporter.These date implicate effector T cells immunotherapy as a powerful regimen to overcome the resistance to chemotherapy.
Downregulation of Varicella-Zoster Virus (VZV) Immediate-Early ORF62 Transcription by VZV ORF63 Correlates with Virus Replication In Vitro and with Latency (2006)

Varicella-zoster virus (VZV) open reading frame 63 (ORF63) protein is expressed during latency in human sensory ganglia. Deletion of ORF63 impairs virus replication in cell culture and establishment of latency in cotton rats. We found that cells infected with a VZV ORF63 deletion mutant yielded low titers of cell-free virus and produced very few enveloped virions detectable by electron microscopy compared with those infected with parental virus. Microarray analysis of cells infected with a recombinant adenovirus expressing ORF63 showed that transcription of few human genes was affected by ORF63; a heat shock 70-kDa protein gene was downregulated, and several histone genes were upregulated. In experiments using VZV transcription arrays, deletion of ORF63 from VZV resulted in a fourfold increase in expression of ORF62, the major viral transcriptional activator. A threefold increase in ORF62 protein was observed in cells infected with the ORF63 deletion mutant compared with those infected with parental virus. Cells infected with ORF63 mutants impaired for replication and latency (J. I. Cohen, T. Krogmann, S. Bontems, C. Sadzot-Delvaux, and L. Pesnicak, J. Virol. 79:5069-5077, 2005) showed an increase in ORF62 transcription compared with those infected with parental virus. In contrast, cells infected with an ORF63 mutant that is not impaired for replication or latency showed ORF62 RNA levels equivalent to those in cells infected with parental virus. The ability of ORF63 to downregulate ORF62 transcription may play an important role in virus replication and latency.
Cell kinetics and response to primary intra–arterial chemotherapy in patients with advanced oral cavity tumors (1991)

The relationship was analyzed between cell kinetics, defined as 3H-thymidine labeling index (3H-TdR LI), and clinical responses for 35 previously untreated patients with locally advanced oral cavity squamous cell carcinomas. Patients were treated with three cycles of vincristine and bleomycin (VB) or of VB plus methotrexate (VBM), given by intra-arterial infusion followed by surgery. The objective clinical response rate was higher after VBM treatment than after VB, whereas overall clinical response rates were similar for patients with slowly or rapidly proliferating tumors. The probability of relapse-free survival at 4 yr and overall survival was significantly higher for patients with high 3H-TdR LI tumors given VBM than for those given VB. For patients with slowly proliferating tumors, there were no differences in relapse-free survival and overall survival between the two treatments. These data suggest that patients with rapidly proliferating tumors benefit from primary intensive chemotherapy treatment including methotrexate and that cell kinetics can be used to formulate rational clinical protocols for oral cavity cancers.
Fuzzy replacement analysis (2002)

In an uncertain economic decision environment, an expert's knowledge about the defender's remaining life and its cash flow information usually consist of a lot of vagueness instead of randomness. To describe a planning horizon which may be implicitly forecasted from past incomplete information, a linguistic description like 'approximately between 10 and 14 years' is often used. A fuzzy replacement analysis for a defender is examined in the paper. The life of the defender is given by a membership function that is an intersection of the membership functions regarding the physical impairment of the defender, its obsolescence, and external economic conditions. A fuzzy economic analysis for a replacement decision is also given.
Image-Based Virtual Fitting System with Garment Image Reshaping (2014)

We propose an image-based virtual fitting system to reproduce the appearance of fitting during online shopping for garments. Inputs are whole-body images of a fashion model and the customer. We create a garment image by cutting out the garment portion from the image of the fashion model. If the garment images were naïvely superimposed, the fitting result would look strange mainly because the shape of the garment will not match the body shape of the customer. In this paper, we therefore propose a method of reshaping the garment image based on human body shapes of the fashion model and the customer to make the fitting result more realistic. The body shape is automatically estimated from the contours of the human body, and can easily be retouched if necessary. The fitting result is refined further by automatic color correction with reference to the facial regions and a method of retouching parts that protrude from the rear of the garment image. We verified the effectiveness of our system through a user test.
Analysis of limb patterning in BMP‐7‐deficient mice (1996)

Bone morphogenetic proteins `BMPs' are polypeptide signaling molecules, belonging to the TGF-β superfamily. They were originally identified by their ability to induce ectopic bone formation, but their expression patterns in embryos suggest multiple functions. BMP-7-deficient mice show among other mesodermal and skeletal patterning defects, polydactyly in the hindlimbs `Luo G, Hofmann C, Bronckers ALJJ, Sohocki M, Bradley A, Karsenty G `1995': Genes Dev 9:2808-2820; Dudley AT, Lyons KM, Robertson EJ `1995': Genes Dev 9:2795-2807'. Here we report a more detailed analysis of the limb phenotype in BMP-7-deficient mice using in situ hybridization to monitor expression of molecules implicated in patterning processes of the developing vertebrate limb. In previous studies we showed that Sonic hedgehog (Shh) was expressed normally, but Hoxd-13 expression in limb mesenchyme was lower in BMP-7 mutant limbs. Here we show that Hoxd-11 expression domains are also contracted and decreased in intensity in mutant limbs, suggesting that 5′ genes of the Hoxd cluster are coordinately downregulated, while another Bmp, Bmp-2, which can be activated by Shh, is similarly expressed. The mutant limb buds are broader than normal buds, and fibroblast growth factor Fgf-8 is expressed throughout the extended ridge. However, expression of the homeobox gene Msx-1, which has been shown to be involved in epithelial-mesenchymal interactions during limb development, was decreased in the mesenchyme of BMP-7 mutant limbs. Taken together, our data suggest that BMP-7 is involved in regulating proliferation and/or epithelial-mesenchymal interactions in the developing limb. © 1996 Wiley-Liss Inc.
The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog. (1995)

The suppressor of Hairy-wing [su(Hw)] protein exerts a polar effect on gene expression by repressing the function of transcriptional enhancers located distally from the promoter with respect to the location of su(Hw) binding sequences. The directionality of this effect suggests that the su(Hw) protein specifically interferes with the basic mechanism of enhancer action. Moreover, mutations in modifier of mdg4 [mod(mdg4)] result in the repression of expression of a gene when the su(Hw) protein is bound to sequences in the copy of this gene located in the homologous chromosome. This effect is dependent on the presence of the su(Hw) binding region from the gypsy retrotransposon in at least one of the chromosomes and is enhanced by the presence of additional gypsy sequences in the other homology. This phenomenon is inhibited by chromosomal rearrangements that disrupt pairing, suggesting that close apposition between the two copies of the affected gene is important for trans repression of transcription. These results indicate that, in the absence of mod-(mdg4) product, the su(Hw) protein present in one chromosome can act in trans and inactivate enhancers located in the other homolog.
A Kalman Filter Implementation for Precision Improvement in Low-Cost GPS Positioning of Tractors (2013)

Low-cost GPS receivers provide geodetic positioning information using the NMEA protocol, usually with eight digits for latitude and nine digits for longitude. When these geodetic coordinates are converted into Cartesian coordinates, the positions fit in a quantization grid of some decimeters in size, the dimensions of which vary depending on the point of the terrestrial surface. The aim of this study is to reduce the quantization errors of some low-cost GPS receivers by using a Kalman filter. Kinematic tractor model equations were employed to particularize the filter, which was tuned by applying Monte Carlo techniques to eighteen straight trajectories, to select the covariance matrices that produced the lowest Root Mean Square Error in these trajectories. Filter performance was tested by using straight tractor paths, which were either simulated or real trajectories acquired by a GPS receiver. The results show that the filter can reduce the quantization error in distance by around 43%. Moreover, it reduces the standard deviation of the heading by 75%. Data suggest that the proposed filter can satisfactorily preprocess the low-cost GPS receiver data when used in an assistance guidance GPS system for tractors. It could also be useful to smooth tractor GPS trajectories that are sharpened when the tractor moves over rough terrain.
Diverse two-cysteine photocycles in phytochromes and cyanobacteriochromes (2011)

Phytochromes are well-known as photoactive red- and near IR-absorbing chromoproteins with cysteine-linked linear tetrapyrrole (bilin) prosthetic groups. Phytochrome photoswitching regulates adaptive responses to light in both photosynthetic and nonphotosynthetic organisms. Exclusively found in cyanobacteria, the related cyanobacteriochrome (CBCR) sensors extend the photosensory range of the phytochrome superfamily to shorter wavelengths of visible light. Blue/green light sensing by a well-studied subfamily of CBCRs proceeds via a photolabile thioether linkage to a second cysteine fully conserved in this subfamily. In the present study, we show that dual-cysteine photosensors have repeatedly evolved in cyanobacteria via insertion of a second cysteine at different positions within the bilin-binding GAF domain (cGMP-specific phosphodiesterases, cyanobacterial adenylate cyclases, and formate hydrogen lyase transcription activator FhlA) shared by CBCRs and phytochromes. Such sensors exhibit a diverse range of photocycles, yet all share ground-state absorbance of near-UV to blue light and a common mechanism of light perception: reversible photoisomerization of the bilin 15,16 double bond. Using site-directed mutagenesis, chemical modification and spectroscopy to characterize novel dual-cysteine photosensors from the cyanobacterium Nostoc punctiforme ATCC 29133, we establish that this spectral diversity can be tuned by varying the light-dependent stability of the second thioether linkage. We also show that such behavior can be engineered into the conventional phytochrome Cph1 from Synechocystis sp. PCC6803. Dual-cysteine photosensors thus allow the phytochrome superfamily in cyanobacteria to sense the full solar spectrum at the earth surface from near infrared to near ultraviolet.
Hybridoma Screening Using an Amplified Fluorescence Microassay to Quantify Immunoglobulin Concentration (1995)

The early identification of antibody-secreting hybridomas significantly reduces the time and resources devoted to unproductive colonies. To quantify the immunoglobulin concentration in hybridoma supernatants within 2 weeks of fusion, we used immunomagnetic microspheres to capture immunoglobulin in the hybridoma culture supernatant. The captured immunoglobulin was detected using a goat anti-mouse second antibody liked to beta-galactosidase. With data transformation to correct for the nonlinear accumulation of the fluorescent reaction product, the enzymatic hydrolysis of fluorescein digalactoside permitted the reliable detection of less than 10 pg of immunoglobulin per milliliter. To determine the value of quantifying immunoglobulin concentration within 2 weeks of fusion, the amplified fluorescence microassay was applied to the evaluation of 3 consecutive fusions and more than 1200 growing hybridoma colonies. Using antibody concentrations greater than 10 ng/ml as a threshold for routine subculture, the selection of hybridoma colonies based on antibody secretion was threefold more efficient than selection based on colony growth alone. These results suggest the utility of the early determination of immunoglobulin concentration in the selection of hybridoma colonies.
A noise-tolerant algorithm for robotic hand-eye calibration with or without sensor orientation measurement (1993)

An iterative algorithm for calibration of a robotic hand-eye relationship is presented. The hand-eye calibration can be performed by solving a system of homogeneous transformation equations of the form A/sub i/X=XB/sub i/, where X is the unknown sensor position relative to the robot wrist, A/sub i/ is the ith robot motion, and B/sub i/ is the ith sensor motion. Unlike existing approaches, the algorithm presented solves the kinematic parameters of X in one stage, thus eliminating error propagation and improving noise sensitivity. Furthermore, with the iterative algorithm, the parameters of X can be computed even when the rotational part of B/sub i/ is unknown. This is important since position is easier to measure than orientation. Comparative simulation studies show that the performance of the iterative algorithm is usually better than that of noniterative two-stage algorithms, regardless of whether the orientation part of B/sub i/ is used or not. This paper also discusses the application of the proposed method to calibration of a tool mounted on a robot manipulator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Effects of phencyclidine on levels of dynorphin 1-17 and dynorphin 1-8 immunoreactivities in various brain regions]. (1986)

Dynorphin (Dyn) is an endogenous ligand of kappa opioid receptor. Our previous work has shown that Dyn was involved in the pathophysiological process of schizophrenia. In this study, the levels of Dyn 1-17 and Dyn 1-8 immunoreactivities (ir) in rat brain regions were investigated after acute and chronic administrations of phencyclidine (PCP), a psychotomimetic drug which causes typical schizophrenia-like symptoms. The results are as follows: (1) In acute administration group, the levels of Dyn 1-17 and 1-8 (ir) in hypothalamus and hippocampus, the levels of Dyn 1-8 in striatum and Dyn 1-17 in frontal cortex were increased markedly, but no significant changes of Dyn 1-17 (ir) in striatum and Dyn 1-8 (ir) in frontal cortex were observed. (2) In chronic administration group, the levels of Dyn 1-17 and 1-8 in frontal cortex were increased and those of Dyn 1-8 in hippocampus were decreased markedly but no significant changes were seen in hypothalamus and striatum. The results suggest that Dyn and endogenous PCP-like substance may be involved in the regulation of mental activity and there are interactions between kappa and PCP/delta opioid receptors in brain.
Carbon phosphide monolayers with superior carrier mobility (2016)

Two dimensional (2D) materials with a finite band gap and high carrier mobility are sought after materials from both fundamental and technological perspectives. In this paper, we present the results based on the particle swarm optimization method and density functional theory which predict three geometrically different phases of the carbon phosphide (CP) monolayer consisting of sp2 hybridized C atoms and sp3 hybridized P atoms in hexagonal networks. Two of the phases, referred to as α-CP and β-CP with puckered or buckled surfaces are semiconducting with highly anisotropic electronic and mechanical properties. More remarkably, they have the lightest electrons and holes among the known 2D semiconductors, yielding superior carrier mobility. The γ-CP has a distorted hexagonal network and exhibits a semi-metallic behavior with Dirac cones. These theoretical findings suggest that the binary CP monolayer is a yet unexplored 2D material holding great promise for applications in high-performance electronics and optoelectronics.
Inhibition of p38 mitogen activate kinase attenuates the severity of pancreatitis-induced adult respiratory distress syndrome (2000)

A component of pancreatic ascites other than endotoxin, bacteria, or cytokines (IL-1beta, TNF, interferon-gamma, or IL-6) is capable of inducing ARDS in healthy animals. Inhibition of p38 mitogen activated kinase decreases the pulmonary injury through attenuated production of TNF-alpha and NO suggesting a primary role for these mediators in pancreatitis-induced ARDS.
Synthesis and Molecular Docking Studies of Novel 2-(2-Amino-6-Phenyl-4-Pyrimidinylamino) Ethanol Derivatives: Using Ring-Opening Reactions of Cyclic Ketene-N,O-Acetal (2017)

Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry. It publishes standard research papers in almost all thrust areas of current chemistry of academic and commercial importance. It provides a platform for rapid publication of quality research papers, reviews and chemistry letters. Oriental Journal of Chemistry is abstracted and indexed in almost all reputed National and International agencies.
V830R/AV: embedded multimedia superscalar RISC processor (1998)

The V830R/AV's real-time decoding of MPEG-2 video and audio data enables practical embedded-processor-based multimedia systems.
Development of the PowerCyber SCADA security testbed (2010)

Meeting current demands for critical infrastructure cyber security education and research will require accurate testbed development. The PowerCyber was designed to closely resemble power grid communication utilizing actual field devices and SCADA software. The testbed provides a novel environment where students can explore cyber attacks and defenses while evaluating their impact on power flow. This paper documents the design and implementation of the testbed while proposing cyber attack scenarios which will negatively affect grid operations. In addition, it documents the results of an initial cyber vulnerability assessment to evaluate the security posture of the current design.
Multiplexing system for fiber-optic sensors using pulse compression techniques (1981)

It is clear that multiplexing will play an important role in future fiber-optic sensor systems. Previously, a time division multiplexing (TDM) approach . was reported that was limited by low average laser power and laser pulse instability.1 in this paper we describe a more advanced multiplexing approach that uses pulse compression techniques to overcome effectively most of the signal-to-noise limitation of the prior TDM method.
Controlling Condensate Collapse and Expansion with an Optical Feshbach Resonance (2013)

We demonstrate control of the collapse and expansion of an (88)Sr Bose-Einstein condensate using an optical Feshbach resonance near the (1)S(0)-(3)P(1) intercombination transition at 689 nm. Significant changes in dynamics are caused by modifications of scattering length by up to ± 10a(bg), where the background scattering length of (88)Sr is a(bg) = -2a(0) (1a(0) = 0.053 nm). Changes in scattering length are monitored through changes in the size of the condensate after a time-of-flight measurement. Because the background scattering length is close to zero, blue detuning of the optical Feshbach resonance laser with respect to a photoassociative resonance leads to increased interaction energy and a faster condensate expansion, whereas red detuning triggers a collapse of the condensate. The results are modeled with the time-dependent nonlinear Gross-Pitaevskii equation.