gebhart/patrepeval huggingface dataset:
Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium (2006)

Oxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxidative stress in blood of such patients. Blood samples of healthy subjects and gynecological patients were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. The results show that alterations of measured parameters vary with the enzyme type and diagnosis. However, both reduction in antioxidants and elevation of lipid peroxidation were observed in general. Lipid hydroperoxides level was negatively correlated to superoxide dismutase and glutathione peroxidase activities, as well as positively correlated to catalase activity. In addition, the lipid hydroperoxides/ glutathione peroxidase ratio was found to be increased, according to the type of uterine disease. The obtained results show that perturbation of antioxidant status is more pronounced in blood of patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions, compared to those with benign uterine changes such as polypus and myoma.
Ground‐Water Sampling and Time‐Series Evaluation Techniques to Determine Vertical Concentration Distributions (1997)

Abstract Data analysis methodologies are developed for using time‐series measurements of effluent concentrations during continuous sampling to determine the vertical shape and location of a horizontally uniform contaminant plume and to estimate physical/ chemical aquifer parameters such as vertical anisotropy, effective porosity, and retardation factor. Temporal water‐quality variations during constant‐flow sampling are calculated in the form of concentration type curves for a wide variety of plume shapes and positions and are shown to be directly related to the geometry and growth rate of the three‐dimensional capture volume of the well. An analytical type‐curve solution is derived for discrete‐interval sampling in homogeneous and isotropic/anisotropic aquifers containing plumes with complex vertical shapes that are described by the superposition of multiple Gaussian distributions. Results from two‐dimensional, axisymmetric simulations of ground‐water flow and particle transport demonstrate the sensitivity of concentration type curves to sandpack hydraulic conductivity, screen length, well diameter, flow through the well screen during discrete‐interval sampling, aquifer anisotropy and heterogeneities, pumping rate, effective porosity, and chemical retardation. Two applications of the concentration type‐curve method for determining plume and aquifer characteristics are presented. The first illustrates the use of discrete‐interval sampling to evaluate the vertical shape and location of a hypothetical plume in a homogeneous, isotropic aquifer. In the second, extraction‐well effluent data collected during a field experiment were used to evaluate the vertical concentration distribution in a sulfate plume and estimate the vertical anisotropy ratio of the aquifer. The results demonstrate the importance of developing consistency in purge and sample volumes to minimize artificial measurement variability in monitoring programs.
Induction of immune tolerance by dendritic cells: Implications for preventative and therapeutic immunotherapy of autoimmune disease (2002)

Dendritic cells (DC) have a key role in controlling the immune response, by determining the outcome of antigen presentation to T cells. Through costimulatory molecules and other factors, DC are involved in the maintenance of peripheral tolerance through modulation of the immune response. This modulation occurs both constitutively, and in inflammation, in order to prevent autoimmunity and to control established immune responses. Dendritic cell control of immune responses may be mediated through cytokine or cell-contact dependent mechanisms. The molecular and cellular basis of these controls is being understood at an increasingly more complex level. This understanding is reaching a level at which DC-based therapies for the induction of immune regulation in autoimmunity can be tested in vivo. This review outlines the current state of knowledge of DC in immune tolerance, and proposes how DC might control both T cell responses, and themselves, to prevent autoimmunity and maintain peripheral tolerance.
Aqueous Solution Process for the Synthesis and Assembly of Nanostructured One-Dimensional α-MoO<sub>3</sub> Electrode Materials (2013)

A low-temperature aqueous solution synthesis of nanostructured one-dimensional (1D) molybdenum trioxide (MoO3) was developed. The subsequent self-assembly of the fibers to form large-scale freestanding films was achieved without any assistance of organic compounds. Indeed, the whole process, from synthesis to assembly, does not require toxic organic solvents. As an example of the application of our synthesized materials, we built two types of half-cell lithium-ion batteries: (i) the cathode made out of 1D MoO3, having the width in 50–100 nm, with the length in micro scale, and with thickness in ∼10 nm, and (ii) the anode made out of the macroscopic oxide papers consisting of 1D MoO3 and carbon materials. As a cathode material, 1D MoO3 showed a high rate capability with a stable cycle performance up to 20 A g–1 as a result of a short Li+ diffusion path along the [101] direction and less grain boundaries. As an anode material, the composite paper compound showed a first specific discharge capacity of 800 mAh g–1. These findings indicate not only an affordable, eco-efficient synthesis and assembly of nanomaterials but also show a new attractive strategy toward a possible full aqueous process for a large-scale fabrication of freestanding oxide paper compounds without any toxic organic solvent.
The role of government in standards (1993)

article Free Access Share on The role of government in standards Author: Gio Wiederhold Stanford Univ., Stanford, CA Stanford Univ., Stanford, CAView Profile Authors Info & Claims StandardViewVolume 1Issue 2Dec. 1993 pp 11–16https://doi.org/10.1145/174690.174692Published:01 December 1993Publication History 2citation288DownloadsMetricsTotal Citations2Total Downloads288Last 12 Months6Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
40 Jahre Römische Verträge - Von der Europäischen Wirtschaftsgemeinschaft zur Europäischen Union (1998)

40 Jahre Römische Verträge - Von der Europäischen Wirtschaftsgemeinschaft zur Europäischen Union was published in 40 Jahre Römische Verträge - Von der Europäischen Wirtschaftsgemeinschaft zur Europäischen Union on page 1.
DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer. (2000)

The gene deleted in malignant brain tumors 1 (DMBT1) has been proposed as a candidate tumor suppressor for brain, gastrointestinal, and lung cancer. It codes for a protein of unknown function belonging to the superfamily of scavenger receptor cysteine-rich proteins. We aimed at getting insights into the functions of DMBT1 by expression analyses and studies with a monoclonal antibody against the protein. The DMBT1 mRNA is expressed throughout the immune system, and Western blot studies demonstrated that isoforms of DMBT1 are identical to the collectin-binding protein gp-340, a glycoprotein that is involved in the respiratory immune defense. Immunohistochemical analyses revealed that DMBT1 is produced by both tumor-associated macrophages and tumor cells and that it is deregulated in glioblastoma multiforme in comparison to normal brain tissue. Our data further suggest that the proteins CRP-ductin and hensin, both of which have been implicated in epithelial differentiation, are the DMBT1 orthologs in mice and rabbits, respectively. These findings and the spatial and temporal distribution of DMBT1 in fetal and adult epithelia suggest that DMBT1 further plays a role in epithelial development. Rearrangements of DMBT1 were found in 16 of 18 tumor cell lines, and hemizygous deletions were observed in a subset of normal individuals, indicating that the alterations in tumors may be a result of both pre-existing deletions uncovered by a loss of heterozygosity and secondary changes acquired during tumorigenesis. Thus, DMBT1 is a gene that is highly unstable in cancer and encodes for a protein with at least two different functions, one in the immune defense and a second one in epithelial differentiation.
The immunoreactivity, ligand, and cell binding characteristics of rheumatoid synovial fluid fibronectin (1985)

Fibronectin promotes macrophage adherence and expression of Fc receptors, is chemotactic for fibroblasts, and is an opsonin for fibrin and denatured collagen. These properties suggest a role for fibronectin in the modulation of joint inflammation. Since structural modification of the fibronectin molecule has been shown to result in loss or de novo acquisition of opsonic and chemotactic activity, we determined the functional and immunochemical properties of fibronectin isolated from the inflamed joint. Eighty-six percent of synovial fluids obtained from patients with active rheumatoid arthritis (RA) contained fibronectin fragments, and 39% of the fluids no longer displayed the dimeric form. Compared with native fibronectin, RA peptides were as active in promoting synoviocyte chemotaxis and in glycosaminoglycan binding, but displayed lower affinity for fibrin and gelatin. Although comparable with intact protein in augmenting monocyte attachment to gelatin, the RA synovial fluid peptides did not augment monocyte attachment to fibrin. Analysis of whole synovial fluid and isolated fibronectins by enzyme immunoassay showed that the increased fibronectin immunoreactivity, previously reported in RA synovial fluid, measures intact and nearly intact protein and does not measure extensively degraded fragments.
High Throughput Monitoring of Amyloid-β42 Assembly into Soluble Oligomers Achieved by Sensitive Conformation State-Dependent Immunoassays (2011)

Accumulation of small soluble assemblies of amyloid-β (Aβ)(42) in the brain is thought to play a key role in the pathogenesis of Alzheimer's disease. As a result, there has been much interest in finding small molecules that inhibit the formation of synaptotoxic Aβ(42) oligomers that necessitates sensitive methods for detecting the initial steps in the oligomerization of Aβ(42). Modeling suggests that oligomerized Aβ(42) adopts a conformation in which the C-terminus is embedded in the center, whereas the N-terminus is exposed at the periphery of the oligomer. Here we report that an inverse change in Aβ(42) C-terminal and N-terminal epitope accessibility provides the basis of a sensitive method for assessing early steps in Aβ(42) oligomerization. Using ELISA and AlphaLISA, we found that Aβ(42) C-terminal immunoreactivity decreased in a time- and concentration-dependent manner under conditions favoring oligomerization. This reduction was accompanied by an increase in the N-terminal immunoreactivity, suggesting that assemblies with multiple exposed N-terminal epitopes were detected. Importantly the assay generates a robust window between monomers and oligomers at as low as 1 nM Aβ(42). Using this assay, known oligomerization inhibitors produced a dose-dependent unmasking of the Aβ(42) C-terminal epitope. After automation, the assay proved to be highly reproducible and effective for high throughput screening of small molecules that inhibit Aβ(42) oligomerization.
Two portable long-term measurement devices for ECG and bioimpedance (2008)

This paper presents an implementation of two portable measurement device prototypes. Both prototypes are targeted for measuring ECG and bioimpedance signals. The first prototype is a wireless type, which sends data in real-time to a PC. The second prototype is a logging device, which stores data to a memory card. After a measurement session data from memory card is transferred to a PC through USB cable. One drawback in the first prototype is a poor usability caused by the limited range of the wireless data link and another drawback is a crosstalk between measured signals. The drawbacks of the first prototype were improved in the second prototype.
Catalytic norbornadiene-butadiene and norbornadiene-1,1-dimethylallene codimerization (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic norbornadiene-butadiene and norbornadiene-1,1-dimethylallene codimerizationAlberto. Greco, A. Carbonaro, and G. Dall'AstaCite this: J. Org. Chem. 1970, 35, 1, 271–274Publication Date (Print):January 1, 1970Publication History Published online1 May 2002Published inissue 1 January 1970https://pubs.acs.org/doi/10.1021/jo00826a067https://doi.org/10.1021/jo00826a067research-articleACS PublicationsRequest reuse permissionsArticle Views258Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Unusual Allylpalladium Carboxylate Complexes: Identification of the Resting State of Catalytic Enantioselective Decarboxylative Allylic Alkylation Reactions of Ketones (2009)

Palladium pop rocks: Hold on to your CO2! Enantioselective palladium-catalyzed decarboxylative alkylation of ketone enolates proceeds via η1-σ-allyl palladium–carboxylate complexes, such as 1 (Pd yellow, O red, N blue, P purple), by slow loss of CO2. Reminiscent of pop rock candy, impure samples of 1 expel a gas (presumably CO2) in the solid state and effervesce in solution.
Golden Mandarin (II)-an improved single-chip real-time Mandarin dictation machine for Chinese language with very large vocabulary (1993)

Golden Mandarin (II) is an improved single-chip real-time Mandarin dictation machine with a very large vocabulary for the input of unlimited Chinese sentences into computers using voice. In this dictation machine only a single-chip Motorola DSP 96002D on an Ariel DSP-96 card is used, with a preliminary character correct rate of around 95% in speaker-dependent mode at a speech of 0.36 s per character. This is achieved by many new techniques, primarily a segmental probability modeling technique for syllable recognition especially considering the characteristics of Mandarin syllables, and a word-lattice-based Chinese character bigram for character identification especially considering the structure of the Chinese language.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optimizations of a Hardware Decoder for Deep-Space Optical Communications (2008)

The National Aeronautics and Space Administration has developed a capacity approaching modulation and coding scheme that comprises a serial concatenation of an inner accumulate pulse-position modulation (PPM) and an outer convolutional code [or serially concatenated PPM (SCPPM)] for deep-space optical communications. Decoding of this code uses the turbo principle. However, due to the nonbinary property of SCPPM, a straightforward application of classical turbo decoding is very inefficient. Here, we present various optimizations applicable in hardware implementation of the SCPPM decoder. More specifically, we feature a Super Gamma computation to efficiently handle parallel trellis edges, a pipeline-friendly ";maxstar top-2"; circuit that reduces the max-only approximation penalty, a low-latency cyclic redundancy check circuit for window-based decoders, and a high-speed algorithmic polynomial interleaver that leads to memory savings. Using the featured optimizations, we implement a 6.72 megabits-per-second (Mbps) SCPPM decoder on a single field-programmable gate array (FPGA). Compared to the current data rate of 256 kilobits per second from Mars, the SCPPM coded scheme represents a throughput increase of more than twenty-six fold. Extension to a 50-Mbps decoder on a board with multiple FPGAs follows naturally. We show through hardware simulations that the SCPPM coded system can operate within 1 dB of the Shannon capacity at nominal operating conditions.
Vasopressin in Congestive Heart Failure (1986)

The mechanisms involved in the abnormal water excretion in patients with congestive heart failure (CHF) are poorly understood. Intrarenal mechanisms (decreased glomerular filtration rate, increased proximal tubular reabsorption) and extrarenal mechanisms (nonosmotic stimulation of arginine vasopressin (AVP)) have been suggested, but their relative importance is unknown. Also, the relationships with altered intracardiac hemodynamics have not been previously assessed. Based on plasma and "platelet" AVP determinations, intracardiac measurements, and other hormonal determinations performed in a series of patients with severe CHF, we conclude that plasma AVP and platelet AVP are the major determinants of the abnormal water excretion in patients with severe CHF. In these patients, enhanced AVP release may be the result of baroreceptor stimulation from a decreased effective arterial blood volume, possibly sensed at specific intraventricular cardiac sites.
[A clinical study of amniotic membrane transplantation for severe eye burns at the acute stage]. (2004)

Amniotic membrane transplantation (especially using a fresh membrane) can effectively reduce the inflammation of the cornea at the acute stage of burn injury, can prevent corneal ulcer and perforation and can make the stabilization process faster. It can also decrease corneal neovascularization as well as establish better conditions for successful keratoplasty.
Design-space exploration of power-aware on/off interconnection networks (2004)

With power a major limiting factor in the design of scalable interconnected systems, power-aware networks become inherent components of single-chip and multi-chip systems. As communication links consume significant power regardless of utilization, we propose and investigate power-aware networks whose links are turned on and off in response to bursts and dips in traffic. We explore the design space of such on/off networks, outlining a 5-step design methodology along with solutions at each step that can form the building blocks of numerous designs. Two specific designs targeting links with substantially different on/off times are then presented and evaluated. Our simulations show that up to 54.4% power savings can be achieved along with at most 7.5% increase in latency.
Stability Considerations of Low-Noise Transistor Amplifiers with Simultaneous Noise and Power Match (2005)

Microwave transistor amplifiers may be simultaneously matched for optimum noise and input/output VSWR. This paper demonstrates a combination of mapping techniques, computer optimization and stability considerations through two amplifier designs (70 MHz and 4000 MHz) to achieve these goals.
<title>Optical properties of human whole blood: changes due to slow heating</title> (1996)

Optical properties of human whole blood were measured in vitro, at 633 nm with a double integrating sphere set-up, The blood was kept at constant flow through a flow cell while slowly heating the blood from approximately 25 degrees C to 55 degrees C in a heat exchanger, The results show a small but distinct decrease in the g-factor of 1.7 +/- 0.6\% and a similar increase in the scattering coefficient, mu(s), of 2.9 +/- 0.6\% at approximately 45-46 degrees C. When studying the thermal effect on the blood cells under a white-light transmission microscope, the changes in the scattering properties could be correlated to a sudden change in the shape of the red blood cells, from disc-shaped to spherical, at approximately the same temperature. Furthermore, a continuous manifest increase in the absorption coefficient, mu(a), was seen with temperature rise, on average 83.8 +/- 68.1\% when reaching the temperature 50 degrees C. This might be due to heat-induced haemolysis of the red blood cells, resulting in free light absorbing haemoglobin in the surrounding plasma and thus higher effective light absorption.
Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial (2003)

To the end of the blinded treatment the NPC trial continued to show a significant protective effect of SS on the overall incidence of prostate cancer, although the effect was restricted to those with lower baseline PSA and plasma selenium concentrations.
The National Association at Work (1940)

(1940). The National Association at Work. The Journal of Health and Physical Education: Vol. 11, No. 4, pp. 205-207.
Copper Metallization for High Performance Silicon Technology (2000)

▪ Abstract The increasingly rapid transition of the electronics industry to high-density, high-performance multifunctional microprocessor Si technology has precipitated migration to new materials alternatives that can satisfy stringent requirements. One of the recent innovations has been the substitution of copper for the standard aluminum-copper metal wiring in order to decrease resistance and tailor RC delay losses in the various hierarchies of the wiring network. This has been accomplished and the product shipped only since the fall of 1998, after more than a decade of intensive development. Critical fabrication innovations include the development of an electroplating process for the copper network, dual-damascence chem-mech polishing (CMP), and effective liner material for copper diffusion barrier and adhesion promotion. The present copper technology provides improved current-carrying capability by higher resistance to electromigration, no device contamination by copper migration, and the performance enhancement analytically predicted. This success of the shift to copper will accelerate the industry movement to finer features and more complex interconnect structures with sufficient device density and connectivity to integrate full systems on chips. The next innovation will be the introduction of low-dielectric constant material that, in combination with copper, will create added excitement as the industry learns how to utilize this new capability.
Can raising cerebral blood flow improve outcome after acute cerebral infarction? (1987)

Cerebral blood flow correlates poorly with outcome after stroke, and most therapies aimed at increasing cerebral perfusion have not succeeded in predictably reducing neurological deficit. Newer approaches such as hemodilution and thrombolysis may prove to be more effective but might be most advantageous if combined with efforts to correct postischemic disturbances in cellular metabolism.