gebhart/patrepeval huggingface dataset:
Real time condition monitoring system for industrial motors (2015)

In generally, predictive maintenance of induction motors is well suited for small to larger scale industries in order to reduce downtime, increase efficiency and reliability. In this paper, the vibration and temperature of the induction motor is analyzed in order to gather specific information that can predict motor's bearing failure. Well analyzed vibration signal easily shows the difference between the running operation of the healthy and faulty motor. Using IoT, this paper shows Real Time Condition Monitoring System for Industrial Motors.
New Insights into the Formation of Aroma-Active Strecker Aldehydes from 3-Oxazolines as Transient Intermediates (2012)

2-Substituted-5-methyl-3-oxazolines, a novel class of aroma precursors that are able to release the respective Strecker aldehydes by hydrolysis, were identified. Hydrolysis can take place after the addition of water or with human saliva during mastication, respectively. 2-Isobutyl-, 2-sec-isobutyl-, 2-isopropyl, and 2-benzyl-5-methyl-3-oxazolines were synthesized and structurally identified by means of gas chromatography–mass spectrometry (GC-MS) in the electron impact mode and in the chemical ionization mode as well as by one- and two-dimensional NMR experiments. With these compounds at hand, a variety of stability experiments were performed using headspace-GC-MS or proton transfer reaction–MS techniques on the basis of stable isotope dilution assays, proving the ability to release the respective Strecker aldehydes was dependent on the pH value as well as on the hydrolysis time. After the addition of water at 37 °C, for example, >70 mol % of 3-methylbutanal or >40 mol % of phenylacetaldehyde was liberated from a solution of 2-isobutyl-5-methyl-3-oxazoline or 2-benzyl-5-methyl-3-oxazoline, respectively, after 5 min. Furthermore, the presence of 2-isobutyl-5-methyl-3-oxazoline in dark chocolate containing 70% cocoa was proven by GC-MS.
Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site. (1991)

Most DNA polymerases are multifunctional proteins that possess both polymerizing and exonucleolytic activities. For Escherichia coli DNA polymerase I and its relatives, polymerase and exonuclease activities reside on distinct, separable domains of the same polypeptide. The catalytic subunits of the alpha-like DNA polymerase family share regions of sequence homology with the 3'-5' exonuclease active site of DNA polymerase I; in certain alpha-like DNA polymerases, these regions of homology have been shown to be important for exonuclease activity. This finding has led to the hypothesis that alpha-like DNA polymerases also contain a distinct 3'-5' exonuclease domain. We have introduced conservative substitutions into a 3'-5' exonuclease active site homology in the gene encoding herpes simplex virus DNA polymerase, an alpha-like polymerase. Two mutants were severely impaired for viral DNA replication and polymerase activity. The mutants were not detectably affected in the ability of the polymerase to interact with its accessory protein, UL42, or to colocalize in infected cell nuclei with the major viral DNA-binding protein, ICP8, suggesting that the mutation did not exert global effects on protein folding. The results raise the possibility that there is a fundamental difference between alpha-like DNA polymerases and E. coli DNA polymerase I, with less distinction between 3'-5' exonuclease and polymerase functions in alpha-like DNA polymerases.
Distribution and Fungicide Sensitivity of Fungal Pathogens Causing Anthracnose-like Lesions on Tomatoes Grown in Ohio (2006)

The primary causal agents of anthracnose-like fruit rots in Ohio and their potential resistance to fungicides commonly used to control these fungal pathogens were determined. Nineteen tomato production fields throughout the state were sampled in 2002 and 2003 for fruit with anthracnose-like lesions. Fungi were isolated from these samples, classified using restriction fragment length polymorphism analysis, and identified by internal transcribed spacer sequence analysis. Some of the fungi isolated may represent secondary invaders of preexisting wounds or lesions. Colletotrichum spp. were most abundant in our collection, representing 136 of the 187 isolates. In addition, there were 23 Alternaria, 12 Fusarium, 12 Phomopsis, and 4 Mucor isolates. Colletotrichum, Alternaria, and Fusarium spp. were found throughout the major tomato production areas in the state. In a laboratory investigation, a subset of the Colletotrichum, Alternaria, and Fusarium isolates caused symptoms similar to early development of anthracnose on wounded tomato fruit. In vitro inhibition assays indicated that most Colletotrichum isolates were sensitive to labeled rates of azoxystrobin, chlorothalonil, and mancozeb. However, some Alternaria isolates were less sensitive to azoxystrobin and chlorothalonil than the Colletotrichum isolates. In addition, most Fusarium isolates were also more insensitive to azoxystrobin and mancozeb, and most Phomopsis isolates were not inhibited by azoxystrobin at the levels tested. The patterns of insensitivity to azoxystrobin and chlorothalonil were also observed in situ with excised fruit. Because the fungicides tested are not currently labeled for control of tomato diseases caused by Fusarium or Phomopsis, these results indicate that some pathogen species that can cause anthracnose-like symptoms may not be entirely sensitive to fungicides commonly used in tomato production.
Enhanced Thermal Conductivity for LWR Fuel (2010)

The thermal conductivity of the fuel in today’s light water reactors, uranium dioxide (UO2), can be improved by incorporating a uniformly distributed heat-conducting network of a higher-conductivity material: silicon carbide (SiC). The higher thermal conductivity of SiC along with its other prominent reactor-grade properties makes it a potential material to address some of the related issues when used in UO2 (97% theoretical density). This ongoing research, in collaboration with the University of Florida, aims to investigate the feasibility and development of a formal methodology for producing the resultant composite oxide fuel. Calculations of the effective thermal conductivity (ETC) of the new fuel as a function of percent SiC for certain percentages and as a function of temperature are presented as a preliminary approach. The ETCs are obtained at different temperatures from 600 to 1600 K. The corresponding polynomial equations for the temperature-dependent thermal conductivities are given based on the simulation results. The heat transfer mechanism in this fuel is explained using a finite volume approach and validated against existing empirical models. FLUENT 6.1.22 was used for the thermal conductivity calculations and to estimate the reduction in centerline temperatures achievable within such a fuel rod. Later, the computer codes COMBINE-PC and VENTURE-PC were employed to estimate the fuel enrichment required to maintain the same burnup levels corresponding to a volume percent addition of SiC.
Studies on viomycin. IX. Amino acid derivatives of viomycin. (1976)

The limited acylations of I on the two amino functions of β-lysine residue with protected amino acid active esters followed by de-protection by catalytic hydrogenolyses resulted N1-amino acid acylated viomycins. While, the limited carbobenzoxylation followed by the reaction with dicarbobenzoxylysine active ester and the decarbobenzoxylation gave N6-acylated product VI. Antimicrobial assay of the above obtained derivatives result that neutral amino acid derivatives of I have reduced potencies while, basic amino acid derivatives possess almost the similar potencies with I in vitro and in vivo tests. Thus, one of the provable reason for the importance of the two free amino functions of β-lysine residue for the exhibition of the potency of I is concluded to be due to their basicity.
Design, Synthesis, and Biological Evaluation of a Series of 2-Hydroxyisoquinoline-1,3(2<i>H</i>,4<i>H</i>)-diones as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain (2008)

We report herein the synthesis of a series of 19 2-hydroxyisoquinoline-1,3(2H,4H)-dione derivatives variously substituted at position 7 aimed at inhibiting selectively two-metal ion catalytic active sites. The compounds were tested against HIV-1 reverse transcriptase (RT) polymerase, HIV-1 RT ribonuclease H (RNase H), and HIV-1 integrase (IN). Most compounds displayed poor inhibition of RT polymerase even at 50 microM. The majority of the synthesized compounds inhibited RNase H and IN at micromolar concentrations, and some of them were weakly selective for IN. Surprisingly, two new hits were discovered, which displayed a high selectivity for IN with submicromolar IC50 values. These enzymatic inhibitory properties may be related to the metal binding abilities of the compounds. Physicochemical studies were consistent with a 1/1 stoichiometry of the magnesium complexes in solution, and the metal complexation was strictly dependent on the enolization abilities of the compounds. Unfortunately, all tested compounds exhibited high cellular cytotoxicity in cell culture which limits their applications as antiviral agents.
Distinct loops in arrestin differentially regulate ligand binding within the GPCR opsin (2012)

G-protein-coupled receptors are universally regulated by arrestin binding. Here we show that rod arrestin induces uptake of the agonist all-trans-retinal [corrected] in only half the population of phosphorylated opsin in the native membrane. Agonist uptake blocks subsequent entry of the inverse agonist 11-cis-retinal (that is, regeneration of rhodopsin), but regeneration is not blocked in the other half of aporeceptors. Environmentally sensitive fluorophores attached to arrestin reported that conformational changes in loop(V-VI) (N-domain) are coupled to the entry of agonist, while loop(XVIII-XIX) (C-domain) engages the aporeceptor even before agonist is added. The data are most consistent with a model in which each domain of arrestin engages its own aporeceptor, and the different binding preferences of the domains lead to asymmetric ligand binding by the aporeceptors. Such a mechanism would protect the rod cell in bright light by concurrently sequestering toxic all-trans-retinal [corrected] and allowing regeneration with 11-cis-retinal.
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (2019)

We conclude that circulating levels of NSPs associate with obesity-related metabolic disorders. Further research is needed to clearly establish the role of these proteases and investigate whether they could be used as non-invasive markers for NAFLD and/or type 2 diabetes.
The RISC-V Instruction Set Manual Volume 2: Privileged Architecture Version 1.7 (2015)

Abstract : This document describes the RISC-V privileged architecture, which covers all aspects of RISC-V systems beyond the user-level ISA, including privileged instructions as well as additional functionality required for running operating systems and attaching external devices.
HEMPAS disease: genetic defect of glycosylation (1990)

Congenital dyserythropoietic anaemia Type II or HEMPAS (hereditary erythroblastic multinuclearity with positive acidified serum lysis test) is a rare genetic anaemia in humans, inherited in an autosomally recessive mode. Biochemical analyses of HEMPAS erythrocyte membranes suggested strongly that HEMPAS is caused by defective glycosylation of erythrocyte membrane glycoproteins. Most recently a HEMPAS case has been identified as being defective in the gene encoding Golgi alpha-mannosidase II by using cDNA probe of alpha-mannosidase II. At present, it is not clear whether HEMPAS is a genetically heterogenous collection of glycosylation deficiencies, as some HEMPAS cases showed a low level of N-acetylglucosaminyltransferase II. Abnormal glycosylation of serum glycoproteins and association of liver cirrhosis in HEMPAS patients indicate that HEMPAS disease is not restricted to erythroid cells. On the other hand, normal development of HEMPAS patients during embryonic stage strongly suggests the possibilities of fetal type isozyme in place of defective glycosylation enzyme.
Study and design of architecture for BCH code encoder and decoder (2010)

Project (M.S., Electrical and Electronic Engineering)--California State University, Sacramento, 2010.
Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains (1990)

The iron transport protein, transferrin, and the iron storage protein ferritin were examined immunohistochemically along with iron in a number of brain regions from normal and aged humans. Two age groups were examined: a middle-aged group (28-49 years), and an older group (60-90 years). Transferrin, ferritin, and iron are found throughout all brain regions examined, predominantly in the perikaryal cytoplasm of cells that are small and round, fitting the description of oligodendrocytes. These cells are present in the optic nerve and in both the gray and white matter of the cerebral cortex, cerebellum, and olfactory bulb in both age groups. Ferritin is also found in microglial cells in the gray matter of most of these brain regions. In the subcortical regions examined (corpus striatum, hippocampus, amygdala), in addition to oligodendrocytes, astrocytes can frequently be observed that contain transferrin, ferritin, and iron. There is an age-related alteration in cell labeling: astrocytes in both gray and white matter contained transferrin in the oldest age group, whereas in the younger group the subcortical transferrin immunoreactivity was confined mostly to oligodendrocytes. Ferritin in the subcortical brain regions is also present in astrocytes but is primarily confined to those in the gray matter, even in the oldest age group. Iron is found predominantly in oligodendrocytes, although a few iron-positive astrocytes and microglia can be identified. These results indicate that (1) normally oligodendrocytes contain much of the iron and iron-binding proteins found in the brain; and (2) an increase in age is associated with altered cellular distribution of iron-binding proteins, but the altered distribution is specific to glial cells. These results suggest glial cells may have previously undescribed functions related to metal regulation and sequestration.
Presence of P<sub>2</sub>‐purinoceptors in the rat pineal gland (1994)

1. The effects of noradrenaline, ATP, adenylyl-imidodiphosphate (AMP-PNP), adenosine, alpha,beta-methylene-ATP and the P2-purinoceptor antagonist, suramin on N'-acetyl-5-hydroxytryptamine production were studied in cultured denervated rat pineal glands. 2. Noradrenaline (3 nM-1 microM) increased N'-acetyl-5-hydroxytryptamine production as measured both in the gland and the culture medium. 3. In noradrenaline (10 nM)-stimulated pineal glands, ATP (0.03 nM-1 mM) or AMP-PNP (0.1 microM-1 mM) increased N'-acetyl-5-hydroxytryptamine production in a concentration-dependent manner. 4. Alpha,beta-Methylene-ATP at the concentration of 0.1 mM, but not 3 microM, attenuated the enhancement by ATP (0.1 mM) of noradrenaline (10 nM)-induced N'-acetyl-5-hydroxytryptamine production. 5. Suramin (0.1 mM) blocked the potentiating effect of ATP (0.1 mM), but not the potentiating effect of adenosine (0.1 mM) in glands incubated with noradrenaline (10 nM). 6. These findings suggest that the rat pineal gland possesses P2-purinoceptors which when stimulated potentiate the effect of noradrenaline but do not, by themselves, induce an increase in N'-acetyl-5-hydroxytryptamine production.
An Alternative Preparation of Steroidal Δ<sup>4</sup>‐3,6‐Diones. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Small-angle x-ray scattering from ternary microemulsions determines microstructure (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSmall-angle x-ray scattering from ternary microemulsions determines microstructureIan S. Barnes, Stephen T. Hyde, Barry W. Ninham, Paul Joel Derian, Maurice Drifford, and Thomas N. ZembCite this: J. Phys. Chem. 1988, 92, 8, 2286–2293Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/j100319a038https://doi.org/10.1021/j100319a038research-articleACS PublicationsRequest reuse permissionsArticle Views352Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Arginine Residues 47 and 70 of Human Flap Endonuclease-1 Are Involved in DNA Substrate Interactions and Cleavage Site Determination (2002)

Flap endonuclease-1 (FEN-1) is a critical enzyme for DNA replication and repair. Intensive studies have been carried out on its structure-specific nuclease activities and biological functions in yeast cells. However, its specific interactions with DNA substrates as an initial step of catalysis are not defined. An understanding of the ability of FEN-1 to recognize and bind a flap DNA substrate is critical for the elucidation of its molecular mechanism and for the explanation of possible pathological consequences resulting from its failure to bind DNA. Using human FEN-1 in this study, we identified two positively charged amino acid residues, Arg-47 and Arg-70 in human FEN-1, as candidates responsible for substrate binding. Mutation of the Arg-70 significantly reduced flap endonuclease activity and eliminated exonuclease activity. Mutation or protonation of Arg-47 shifted cleavage sites with flap substrate and significantly reduced the exonuclease activity. We revealed that these alterations are due to the defects in DNA-protein interactions. Although the effect of the single Arg-47 mutation on binding activities is not as severe as R70A, its double mutation with Asp-181 had a synergistic effect. Furthermore the possible interaction sites of these positively charged residues with DNA substrates were discussed based on FEN-1 cleavage patterns using different substrates. Finally data were provided to indicate that the observed negative effects of a high concentration of Mg(2+) on enzymatic activity are probably due to the competition between the arginine residues and metal ions with DNA substrate since mutants were found to be less tolerant.
A review on interface modification and characterization of natural fiber reinforced plastic composites (2001)

Abstract An Important aspect with respect to optimal mechanical performance of fiber reinforced composites in general and durability in particular is the optimization of the interfacial bond between fiber and polymer matrix. The quality of the fiber‐matrix interface is significant for the application of natural fibers as reinforcement for plastics. Since the fibers and matrices are chemically different, strong adhesion at their interfaces is needed for an effective transfer of stress and bond distribution throughout an Interface. A good compatibilization between cellulose fibers and non‐polar matrices is achieved from polymeric chains that will favor entanglements and interdiffiusion with the matrix. This article gives a critical review on the physical and chemical treatment methods that improve the fiber‐matrix adhesion and their characterization methods.
Pathogenicity of Spiroplasma sp. strain SMCA in rabbits: clinical, microbiological, and histological aspects (1981)

Newborn rabbits inoculated intracerebrally with early-passaged broth cultures of Spiroplasma strain SMCA (suckling mouse cataract agent) either died or developed eye disease. Death occurred 4 to 12 days after infection. Rabbits which died showed hemorrhages throughout the brain, especially in areas leading to the optic nerve, and hemorrhages in the liver. SMCA could be reisolated from brain, liver, and eyes. Rabbits with eye disease did not open their eyes during an observation time of 3 to 4 months. Pathological examination revealed marked microophthalmia and severe cataract formation characterized by complete degeneration of lens fibers and liquefaction and mineralization of the lens. Other ocular changes were chronic panophthalmitis with complete destruction of the retina. Neither eye disease nor death could be induced by inoculating SMCA subcutaneously into newborn rabbits. In adult rabbits, no disease occurred after intravenous or subcutaneous injection or after inoculation into the conjunctival sac.
Blood-injury-illness phobia: A review (1985)

The empirical literature that pertains to phobias of blood, injury, or illness (BII) is surveyed. BII phobia is selectively associated with a vasovagal fainting response upon exposure to phobic stimuli, and the clinical entity may represent an exaggeration of a response that is relatively prevalent in the general population. Clinical, demographic and etiological information obtained from a series of 15 BII phobics is presented, and the suggestion is made that this disorder warrants a diagnostic category separate from simple phobia.
Plasma Fibroblast Growth Factor 23 Concentration Is Associated with Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients (2020)

The plasma FGF23 may be a potential biomarker for cerebral atherosclerosis, particularly the presence and burden of ICAS in stroke patients.