gebhart/patrepeval huggingface dataset:
“Service user involvement in practice”: The evaluation of an intervention program for service providers and inpatients in Norwegian Community Mental Health Centers (2010)

Background: Modern mental health strategies emphasize the necessity of user participation, but only a few studies examine how user involvement can be promoted effectively. Aim: To study the possible effect of an intervention program designed to (1) increase attention to user involvement and (2) increase user involvement at the inpatient departmental level. Methods: The study has a quasi‐experimental design, involving inpatient departments in five Norwegian Community Mental Health Centers (CMHCs). Two CMHCs received the intervention, and were compared with three CMHCs that did not. The impact of the intervention was assessed with the Service User Involvement in Mental Health Scale (SUIM), a selection of items from the Consumer Participation Questionnaire (CPQ) and the Psychiatric Inpatient Experience Questionnaire (PIPEQ). One hundred and twenty‐three service providers, 51 in the intervention group and 72 in the comparison group, and 47 inpatients took part in the study. Results: Providers in the intervention group reported higher mean scores at follow‐up for the variables of organizational user involvement, patient collaboration, and carer involvement than the comparison group. The intervention program was not associated with inpatients reporting more satisfaction with care. Conclusion: An intervention program can be useful in increasing attention to service user involvement in inpatient mental health services.
1925 fall planting catalog / (1925)

No home is complete without a small section of the back yard set out to a few vegetables. How handy in an emergency to go out into your garden and pull a few Radishes, Carrots or cut a head of Lettuce. We are this year offering a complete Vegetable Garden for a trifle in cost.
Aquatic Toxicology and Hazard Assessment (1981)

Description The book covers discussions of new concepts, methods and research results in aquatic toxicology and hazard assessment. This book is broken down into three sections: safety margins; environmental chemistry and fate modeling; and application of aquatic hazard assessment principles.
Synthesis and Structure–Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3-<i>b</i>]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity (2019)

There are currently no approved drugs for the treatment of emerging viral infections, such as dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a cellular serine-threonine protein kinase that functions as a key regulator of the clathrin-associated host adaptor proteins and regulates the intracellular trafficking of multiple unrelated RNA viruses. Moreover, AAK1 is overexpressed specifically in dengue virus-infected but not bystander cells. Because AAK1 is a promising antiviral drug target, we have embarked on an optimization campaign of a previously identified 7-azaindole analogue, yielding novel pyrrolo[2,3- b]pyridines with high AAK1 affinity. The optimized compounds demonstrate improved activity against dengue virus both in vitro and in human primary dendritic cells and the unrelated Ebola virus. These findings demonstrate that targeting cellular AAK1 may represent a promising broad-spectrum antiviral strategy.
Regulators of plant biomass degradation in ascomycetous fungi (2017)

Fungi play a major role in the global carbon cycle because of their ability to utilize plant biomass (polysaccharides, proteins, and lignin) as carbon source. Due to the complexity and heterogenic composition of plant biomass, fungi need to produce a broad range of degrading enzymes, matching the composition of (part of) the prevalent substrate. This process is dependent on a network of regulators that not only control the extracellular enzymes that degrade the biomass, but also the metabolic pathways needed to metabolize the resulting monomers. This review will summarize the current knowledge on regulation of plant biomass utilization in fungi and compare the differences between fungal species, focusing in particular on the presence or absence of the regulators involved in this process.
A New Biscoumarin from Citrus Plants (1993)

A new dimeric coumarin (biscoumarin) named bisparasin (1) was isolated from some hybrid plants of Citrus species. On the basis of spectrometric analyses, the structure was characterized as a [2+4] cycloaddition adduct between trans-dehydroosthol (2) and citrubuntin (3).
An automatic lung cancer detection from X-ray images obtained through yearly serial mass survey (2002)

A fully automatic method of detecting new lung nodules based on the subtraction method between two serial mass chest radiographs is proposed. Nodule detection is carried out following the three steps: pre-processing, subtraction and post-processing. In the pre-processing step, the outline of the bilateral lungs is extracted and modified in order to perform good subtraction between the two images to be compared. In the post-processing step, limitation and localization of candidate nodules of lung cancer are carried out. In these two steps, an evaluator function called "simpleness" of a single connection region is applied to identify outline of the lung and to select candidates of cancer(s).
An adaptive fuzzy logic controller: its VLSI architecture and applications (2000)

Most previous work about the hardware design of a fuzzy logic controller (FLC) intended to either improve its inference performance for real-time applications or to reduce its hardware cost. To our knowledge, there has been no attempt to design a hardware FLC that can perform an adaptive fuzzy inference for the applications of on-line adaptation. The purpose of this paper is to present such an adaptive memory-efficient FLC and its applications. Taking advantage of the adaptability provided by a symbolic fuzzy rule format and the dynamic membership function generator, as well as the high-speed integration capability afforded by VLSI, the proposed adaptive fuzzy logic controller (AFLC) can perform an adaptive fuzzy inference process using various inference parameters, such as the shape and location of a membership function, dynamically and quickly. Three examples are used to illustrate its applications, and the experimental results show the excellent adaptability provided by AFLC.
Autonomic Healing of Epoxy Vinyl Esters via Ring Opening Metathesis Polymerization (2007)

Abstract A materials system for autonomic healing of epoxy vinyl esters is demonstrated. The system is comprised of wax microspheres containing Grubbs' catalyst and microcapsules containing exo ‐dicyclopentadiene (DCPD) embedded together in an epoxy vinyl ester matrix. Healing is triggered when damage in the form of a crack ruptures the microcapsules, causing DCPD to be released into the crack plane where it comes in contact and mixes with the catalyst microspheres initiating ring opening metathesis polymerization (ROMP). The chemical compatibility of the catalyst with the matrix is investigated and wax protection of the catalyst via microspheres of a sufficient size (34–98 μm) is shown to provide a suitable barrier for protecting the catalyst from free radicals generated in situ during the curing of the epoxy vinyl ester resin. Wax protection of the catalyst also allows uninhibited curing of the matrix to proceed at room temperature. Concentration of self‐healing components is varied with a view towards optimization of the recovery of virgin mechanical properties. Efficient self‐healing is observed with microspheres that are smaller than those used in previous polymer matrices. Significant recovery of virgin mechanical properties is observed within 2.5 min of healing time at room temperature and the mechanical properties of healed samples after 24 h of healing time match those of existing ROMP‐based self‐healing systems.
Stress-Induced ClpP Serine Protease of<i>Listeria monocytogenes</i>Is Essential for Induction of Listeriolysin O-Dependent Protective Immunity (2001)

The stress-induced protease ClpP is required for virulence of the facultative intracellular pathogen Listeria monocytogenes. We previously found that in the absence of ClpP, the virulence of this pathogen was strongly reduced, mainly due to the decreased production of functional listeriolysin O (LLO), a major immunodominant virulence factor promoting intracellular growth. In this work, a clpP deletion mutant of L. monocytogenes was used to study the generation of anti-Listeria protective immunity. We found that ClpP is required for the intracellular growth of L. monocytogenes in resident macrophages in vivo. Mice infected with doses as high as 10(6) clpP mutant bacteria were not protected against a lethal challenge of wild-type bacteria and did not develop any detectable LLO-specific cytolytic T cells or antibodies, suggesting that the amount of LLO produced in infected mice under these conditions was too low to induce a specific immune response. However, in contrast to the results obtained with a mutant with a disrupted hly gene, this lack of protection was overcome by inoculation of very high infecting doses of clpP mutant bacteria (5 x 10(8)), thus producing sufficient amounts of LLO to stimulate anti-Listeria immunity. The role of ClpP was confirmed by showing that anti-Listeria immunity was restored in mice infected with a clpP-complemented mutant. These results indicate that the stress-induced serine protease ClpP is a potential target for modulating the presentation of protective antigens such as LLO and thereby the immune response against L. monocytogenes.
Ultrafast physical generation of random numbers using hybrid Boolean networks (2013)

We describe a high-speed physical random number generator based on a hybrid Boolean network with autonomous and clocked logic gates, realized on a reconfigurable chip. The autonomous logic gates are arranged in a bidirectional ring topology and generate broadband chaos. The clocked logic gates receive input from the autonomous logic gates so that random numbers are generated physically that pass standard randomness tests without further postprocessing. The large number of logic gates on reconfigurable chips allows for parallel generation of random numbers, as demonstrated by our implementation of 128 physical random number generators that achieve a real-time bit rate of 12.8Gbits/s.
Comparison of the Surface Charge Behavior of Commercial Silicon Nitride and Silicon Carbide Powders (1988)

The adsorption and desorption of protons from aqueous solution onto the surfaces of a variety of commercial silicon carbide and silicon nitride powders has been examined using a surface titration methodology. This method provides information on some colloidal characteristics, such as the point of zero charge (pzc) and the variation of proton adsorption with dispersion pH, useful for the prediction of optimal ceramic‐processing conditions. Qualitatively, the magnitude of the proton adsorption from solution reveals small differences among all of the materials studied. However, the results show that the pzc for the various silicon nitride powders is affected by the powder synthesis route. Complementary investigations have shown that milling can also act to shift the pzc exhibited by silicon nitride powder. Also, studies of the role of the electrolyte in the development of surface charge have indicated no evidence of specific adsorption of ammonium ion on either silicon nitride or silicon carbide powders.
Alprazolam treatment of avoidant personality traits in social phobic patients. (1989)

The authors examined the effect of alprazolam treatment on avoidant personality traits in 14 DSM-III-R social phobics. Six of the nine avoidant traits examined improved with treatment. However, all but one trait (avoiding social or occupational activities requiring interpersonal contact) returned to baseline levels posttreatment. Treatment response and intercorrelation of items indicated two traits that may represent a separate segment of avoidant personality: "No close friends or confidants outside of relatives and family members" and "Exaggerates the potential dangers or risks of everyday situations."
Interactions Between Bladder Tumor Cells as Tumor Spheroids from the Cell Line J82 and Human Endothelial Cells in Vitro (1988)

Multicellular tumor spheroids (MCTS) are a reliable model of nonvascularized tumor cell aggregates showing a well defined three-dimensional growth pattern and are comparable with small metastatic cancer cell complexes in blood circulation. In the present study we have established a co-culture system of multicellular bladder tumor spheroids with human endothelial cells on extracellular matrix (ECM) in order to investigate morphological and proliferative changes of endothelial and tumor cells within a defined time of cell-cell interaction. The MCTS--endothelial cell--extracellular matrix complex was observed within coculture periods from 1/2 to seven days. Morphological changes (light microscopy, scanning and electron microscopy) indicated that MCTS are not influenced by cocultured endothelial cells. The tumor cells invaded into the ECM after degradation of endothelial cells in the center of the contact zone. Endothelial cells, however, showed degenerative changes as well as a complex reaction in their proliferation activities. We could recognize an initial increase of proliferation of endothelial cells next to the MCTS. Later on, endothelial cells next to invading tumor cells showed changes in morphological polarity. The model system used has the advantage of using human tumor tissue. It distinguishes between basic cellular mechanisms like adherence, migration, DNA synthesis and proliferation in the study of the contact of tumor cells and vascular endothelial cells as an important event in hematogenous tumor spread.
Critical evaluation of observed adverse effects of endocrine active substances on reproduction and development, the immune system, and the nervous system (2003)

The last 40 years have seen many reports that man-made chemicals and environmental pollutants cause adverse effects in humans and wildlife; however, actually linking an exposure with a mechanism and an effect has yet to be done for endocrine disruption. Certainly, studies in experimental animals have shown that sufficient doses of select compounds can disrupt the endocrine system and produce the attendant adverse outcomes. The purpose of this contribution is to evaluate some of the recent reports of the adverse effects on reproduction and development, the immune system, and the nervous system that have been observed in experimental animals after treatment with man-made chemicals and environmental pollutants. Space limitations prevent us from presenting a comprehensive review of all reported endocrine active chemicals and their effects. Instead, we have focused on drawing conclusions as to the scope and etiology of the adverse effects in experimental animals using examples from the scientific literature, and on suggesting a path forward for further work.
Focal sets of submanifolds (1978)

This is a study of the manifold structure of the focal set of an immersed submanifold in a real space form M. A typical result is the following:
Temperature Effects in Asymmetric Dihydroxylation: Evidence for a Stepwise Mechanism (1993)

For more than 50 years, the accepted opinion was that the dihydroxylation of olefins with OsO4 proceeded by a concerted mechanism [Eq. (a)]. However, if the influence of the reaction temperature on the enantiomeric excesses in asymmetric dihydroxylations is studied, Eyring plots are obtained with inversion points, which is consistent with a stepwise mechanism.
XML based description model as a platform for web-based maintenance (2005)

Web technologies are gaining increased importance in automation and control systems. The choice of appropriate Web technologies depends on the use cases in the application environment. However, it is important not only to focus on one single technology, but to combine and to integrate different Web technologies within a portal. The paper discusses such a Web portal for maintenance purposes, which uses several Web technologies. It is based on a model describing the relations between topological and functional entities of the application system and the single Web technologies used. This hierarchical description model is defined in XML. The structure of this model is described and the use of description information for the realization of different functionality is shown. Special attention is paid to the security features of the solution. This requires specific description elements, ensuring access to description is limited to functional roles or user personalization. Different implementation aspects, and experiences derived from two prototype implementations are discussed
Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma (2014)

Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal functions remain poorly understood. Using cell-specific inducible gene recombination in mice we found that, in the postnatal inner ear, Bbnf and Ntf3 are required for the formation and maintenance of hair cell ribbon synapses in the vestibular and cochlear epithelia, respectively. We also show that supporting cells in these epithelia are the key endogenous source of the neurotrophins. Using a new hair cell CreER(T) line with mosaic expression, we also found that Ntf3's effect on cochlear synaptogenesis is highly localized. Moreover, supporting cell-derived Ntf3, but not Bbnf, promoted recovery of cochlear function and ribbon synapse regeneration after acoustic trauma. These results indicate that glial-derived neurotrophins play critical roles in inner ear synapse density and synaptic regeneration after injury.
Search for ion‐cyclotron resonance in an Na<sup>+</sup>‐transport system (1991)

Colonic tissue from the turtle (Pseudemys scripta) was exposed in a Ussing chamber to simultaneously applied static and time-varying magnetic fields. Transepithelial differences of potential were monitored as frequency of the AC field was varied continuously or in discrete steps from 3 to 770 Hz. Density of the DC field was varied from 10 to 220 microT and that of the AC field from 1 to 20 microT. Short-circuit currents through tissue were monitored for changes that might have been observed under ion-cyclotron resonance (ICR) conditions for each of several ions: H+, Li+, Na+, K+, Ca2+, and Cl-. No discernible changes of transepithelial current were observed. The negative findings are discussed in relation to positive and negative findings that have appeared in the literature.
Research on Extension of GM(1,1) and Its Modeling Mechanism (2011)

As a basic prediction model, GM(1,1) is widely used. Although the grey forecasting model has been successfully adopted in various fields and demonstrated promising results, the literatures show its performance could be further improved. For this purpose, the paper proves that the growth rate of the simulated value of the grey GM(1,1) is a fixed value. If the growth rates of the primary sequence are equate, the fitted value deriving from GM(1,1) is the same as the primary sequence, otherwise greater error would occur. In order to overcome shortcoming of the fixed growth rates, GM(1,1) is extended by introducing linear time-varying terms. A novel forecasting model is proposed, termed EGM(1,1). Meanwhile, by contrasting EGM(1,1) model to the GM(1,1) model, the result shows that EGM(1,1) model has largely improves fitting and predicting precision.
On the Control of Short-Channel Effect for MOSFETs With Reverse Halo Implantation (2007)

Reverse halo implantation (RHI), for the first time, is introduced and used to fabricate MOSFETs. It was demonstrated that RHI can dramatically improve short-channel effect, which can be used to enhance MOSFET performance, improve process control, or reduce stand-by power consumption. Implantation damage of RHI to gate oxide is negligible. The method of RHI is economic and suitable for massive manufacturing of very large scale integration
Enhancing the Identification of Phosphopeptides from Putative Basophilic Kinase Substrates Using Ti (IV) Based IMAC Enrichment (2011)

Metal and metal oxide chelating-based phosphopeptide enrichment technologies provide powerful tools for the in-depth profiling of phosphoproteomes. One weakness inherent to current enrichment strategies is poor binding of phosphopeptides containing multiple basic residues. The problem is exacerbated when strong cation exchange (SCX) is used for pre-fractionation, as under low pH SCX conditions phosphorylated peptides with multiple basic residues elute with the bulk of the tryptic digest and therefore require more stringent enrichment. Here, we report a systematic evaluation of the characteristics of a novel phosphopeptide enrichment approach based on a combination of low pH SCX and Ti(4+)-immobilized metal ion affinity chromatography (IMAC) comparing it one-to-one with the well established low pH SCX-TiO(2) enrichment method. We also examined the effect of 1,1,1,3,3,3-hexafluoroisopropanol (HFP), trifluoroacetic acid (TFA), or 2,5-dihydroxybenzoic acid (DHB) in the loading buffer, as it has been hypothesized that high levels of TFA and the perfluorinated solvent HFP improve the enrichment of phosphopeptides containing multiple basic residues. We found that Ti(4+)-IMAC in combination with TFA in the loading buffer, outperformed all other methods tested, enabling the identification of around 5000 unique phosphopeptides containing multiple basic residues from 400 μg of a HeLa cell lysate digest. In comparison, ∼ 2000 unique phosphopeptides could be identified by Ti(4+)-IMAC with HFP and close to 3000 by TiO(2). We confirmed, by motif analysis, the basic phosphopeptides enrich the number of putative basophilic kinases substrates. In addition, we performed an experiment using the SCX/Ti(4+)-IMAC methodology alongside the use of collision-induced dissociation (CID), higher energy collision induced dissociation (HCD) and electron transfer dissociation with supplementary activation (ETD) on considerably more complex sample, consisting of a total of 400 μg of triple dimethyl labeled MCF-7 digest. This analysis led to the identification of over 9,000 unique phosphorylation sites. The use of three peptide activation methods confirmed that ETD is best capable of sequencing multiply charged peptides. Collectively, our data show that the combination of SCX and Ti(4+)-IMAC is particularly advantageous for phosphopeptides with multiple basic residues.
27.6 A 4GS/s 13b pipelined ADC with capacitor and amplifier sharing in 16nm CMOS (2016)

In recent years, we have seen the emergence of multi-GS/s medium-to-high-resolution ADCs. Presently, SAR ADCs dominate low-speed applications and time-interleaved SARs are becoming increasingly popular for high-speed ADCs [1,2]. However the SAR architecture faces two key problems in simultaneously achieving multi-GS/s sample rates and high resolution: (1) the fundamental trade-off of comparator noise and speed is limiting the speed of single-channel SARs, and (2) highly time-interleaved ADCs introduce complex lane-to-lane mismatches that are difficult to calibrate with high accuracy. Therefore, pipelined [3] and pipelined-SAR [4] remain the most common architectural choices for high-speed high-resolution ADCs. In this work, a pipelined ADC achieves 4GS/s sample rate, using a 4-step capacitor and amplifier-sharing front-end MDAC architecture with 4-way sampling to reduce noise, distortion and power, while overcoming common issues for SHA-less ADCs.