gebhart/patrepeval huggingface dataset:
5-HT2A receptor antagonist increases circulating adiponectin in patients with type 2 diabetes (2005)

We compared the levels of plasma adiponectin, platelet activation markers (P-selectin, CD63, PAC-1, annexin V, and platelet-derived microparticles), and endothelial injury markers (soluble E-selectin and soluble vascular cell adhesion molecule-1) in 53 patients with type 2 diabetes mellitus to investigate potential contributions to diabetic vascular complications. In addition, we administered serotonin antagonist (sarpogrelate hydrochloride) to type 2 diabetes patients who had increased soluble E-selectin levels. The concentrations of platelet activation markers and endothelial injury markers in diabetic patients were significantly higher than those in normal subjects. However, levels of adiponectin were lower in type 2 diabetes patients than in control subjects. A total of 32 patients had high-soluble E-selectin levels (soluble E-selectin >or= 62 ng/ml); a subset of patients that also had significant elevation of platelet activation and endothelial injury markers compared with patients without high soluble E-selectin. In addition, both platelet-P-selectin and platelet-derived microparticle levels negatively correlated with the adiponectin level. Patients with high soluble E-selectin exhibited significant improvement of all markers after sarpogrelate hydrochloride treatment. These findings suggest that there is a link between vascular change in type 2 diabetes and activated platelets, endothelial dysfunction, and an adiponectin abnormality.
Effects of Sintering Route and Flux on the Luminescence and Morphology of YAG: Ce Phosphors for White Emitting-Light Diodes (LEDs) (2012)

YAG:Ce phosphors were synthesized by co-precipitation method. The photoluminescence intensity of samples sintered by the two-step route increases by about 10%, and with 0.5 wt.% NH4Cl added as flux, surface morphologies and size distribution are improved. The white LEDs were fabricated using as-obtained phosphors. It shows natural white light with chromaticity coordinates of (0.3083, 0.3163), color temperature (Tc) of 6886 K, the average CRI of 75, and the luminous efficacy of 85 ml/W. Therefore, The as-obtained YAG:Ce phosphors could be regard to have potential application in white LED devices.
An Improved, Efficient Method for Analyzing Human Sperm Chromosomes Using Zona-Free Hamster Ova (1987)

Department of Biological Sciences, Asahikawa Medical College, 4-5 Nishikagura, Asahikawa, Japan Am. J. Hum. Genet. 38: 724, 1986
Exploratory studies on fast pyrolysis oil upgrading (2007)

Pyrolysis oil is a dark brown liquid which can be produced in high yield from different kind of biomass sources by means of fast pyrolysis. Pyrolysis oil is considered as a promising second generation energy carrier and may play an important role in the future of biobased economies. The energy content of pyrolysis oil is approximately half of fossil crude. Just like for crude oil, further reprocessing is necessary to arranged pyrolysis oil as fuel in e.g. combustion engines. This thesis describes the results of exploratory research of pyrolysis oil upgrading for biofuel production. For that purpose two promising options have been examined. The first route includes the treatment of pyrolysis oil with hydrogen at elevated temperatures and presses in the presence of metal catalysts. It appears that the properties of oil improved considerably by using solid catalysts based on ruthenium. Moreover a mild treatment using homogeneous metal catalysts also shows a promising option. The Second part of the research has an objective on improving pyrolysis oil properties by mixing with alcohol as a reagent. It appears that reactive distillation using butanol leads to a considerable improvement of important product properties such as viscosity, acid quality and energy contents.
The Otto Aufranc Award. Lovastatin prevents steroid induced adipogenesis and osteonecrosis. (1997)

Osteonecrosis of the femoral head was induced experimentally in chickens after the administration of a high dose of corticosteroids. Lovastatin was used to prevent the effects of the steroid on adipogenesis in cultured cells, and adipogenesis and osteonecrosis in chickens. The in vitro study, with marrow cells in culture, showed that Lovastatin inhibited steroid induced fat specific gene expression and counteracted the inhibitory effects of steroids on osteoblastic gene expression. For the in vivo study, 83 adult chickens were used: 48 received methylprednisolone 3 mg/kg weekly via intramuscular injection (Group A). Fifteen received the steroid (as in Group A) plus Lovastatin 20 mg per animal per day orally (Group B). Ten chickens received Lovastatin only (Group C). Another 10 received no medication and served as the control group (Group D). Evidence of osteonecrosis was observed in specimens from Group A, including subchondral bone death and resorption, fat cell proliferation, and new bone formation. Conversely, sections from Group B showed less adipogenesis and no bone death. It is concluded that the bipedal chicken is a useful animal model for studies of osteonecrosis and that lipid clearing agents, such as Lovastatin, may be helpful in preventing the development of steroid induced osteonecrosis.
An efficient ODT calibration scheme for improved signal integrity in memory interface (2010)

An Input Output (IO) Buffer for memory Interface is proposed with the concept of a merged driver which helps in improving the linearity of the driver with a reduced area. A novel calibration scheme is proposed which can adjust larger driver resistance and termination impedance changes for temperature and voltage drifts in a fewer cycles of system clock which will improve the valid data window.
Increased serum levels of chromogranin A in male smokers with airway obstruction (2006)

The neuroendocrine (NE) system may play an important role in smoking-induced airway diseases. The aim of the present study was to examine the relationship between serum levels of the general NE marker chromogranin A (CgA) and smoking habits, respiratory symptoms and lung function. The study population consisted of never-smokers with normal lung function, smokers with normal lung function and smokers with airway obstruction who were randomly selected from the lung study of the Nord-Trøndelag Health Study (HUNT). Serum CgA was determined in 151, 138 and 116 subjects, respectively. All subjects were seronegative for Helicobacter pylori. Male smokers with airway obstruction had significantly higher serum CgA levels (median 3.70 nmol x L(-1) (interquartile range 3.10-5.15)) than both smokers with normal lung function (3.00 nmol x L(-1) (2.50-3.67)) and never-smokers with normal lung function (2.90 nmol x L(-1) (2.57-3.30)). The elevated levels of CgA correlated with the degree of airway obstruction. Moreover, the presence of respiratory symptoms and chronic bronchitis among male smokers were associated with increased serum CgA levels. Females had CgA levels similar to male smokers independent of smoking status and lung function. Elevated serum chromogranin A levels in subjects with airway obstruction and respiratory symptoms may represent neuroendocrine activation in inflammatory or remodelling processes in the lung.
Using anytime algorithms in intelligent systems (1996)

Anytime algorithms give intelligent systems the capability to trade deliberation time for quality of results. This capability is essential for successful operation in domains such as signal interpretation, real-time diagnosis and repair, and mobile robot control. What characterizes these domains is that it is not feasible (computationally) or desirable (economically) to compute the optimal answer. This article surveys the main control problems that arise when a system is composed of several anytime algorithms. These problems relate to optimal management of uncertainty and precision. After a brief introduction to anytime computation, I outline a wide range of existing solutions to the metalevel control problem and describe current work that is aimed at increasing the applicability of anytime computation.
Coagulation parameters in apheresis and leukodepleted whole‐blood plasma during storage (2007)

Leukodepleted apheresis and WB plasma stored for 14 days retain sufficient levels of FV and FVIII activity for maintenance of normal hemostasis and could therefore be considered useful in selected clinical situations.
Reconfigurable-order bandpass filter for frequency agile systems (2010)

This paper presents a tunable bandpass filter with a reconfigurable filter order. The proposed filter consists of an array of tunable resonators with variable inter-resonator coupling structures between adjacent cavities. This allows the frequency selectivity of the filter to be adjusted for the given spectral environment without any geometrical modifications to the filter structure. To demonstrate the concept a 2 × 2 resonator array is fabricated using substrate integrated evanescent-mode cavity resonators at 3.2 GHz. Each resonator has an adjustable frequency response and can be tuned from 2.77 to 3.55 GHz. The filter has two separate signal paths, either through two or four resonators. The reconfigurable inter-resonator coupling is implemented with floating vias inside a coupling iris. The vias are connected using variable capacitors and can be included or excluded from the iris by adjusting the capacitance. This structure shows the potential for the inclusion of reconfigurable-order filters in future agile radio systems.
Characterization of the Rv3378c Gene Product, a New Diterpene Synthase for Producing Tuberculosinol and (13<i>R</i>,<i>S</i>)-Isotuberculosinol (Nosyberkol), from the<i>Mycobacterium tuberculosis</i>H37Rv Genome (2011)

The Rv3377c and Rv3378c genes from Mycobacterium tuberculosis are specifically found in the virulent Mycobacterium species, but not in the avirulent species. The Rv3378c-encoded enzyme produced tuberculosinol 2 (5(6), 13(14)-halimadiene-15-ol), 13R-5a and 13S-isotuberculosinol 5b (5(6), 14(15)-halimadiene-13-ol) as its enzymatic products from tuberculosinyl diphosphate 3, indicating that the Rv3378c enzyme catalyzed the nucleophilic addition of a water molecule after the release of a diphosphate moiety. The three enzymatic products 2, 5a, and 5b were produced irrespective of the N- and C-terminal His-tagged Rv3378c enzymes, and of the maltose-binding protein fusion enzyme; the product distribution ratio was identical between the enzymes as 1:1 for 2:5, and 1:3 for 5a:5b. The successful separation of 5a and 5b by a chiral HPLC column provided the first complete assignments of ¹H- and ¹³C-NMR data for 5a and 5b. The enzymatic mechanism for producing 2, 5a, and 5b is proposed here, and the optimal catalytic conditions and kinetic parameters, in addition to the divalent metal effects, are described. Site-directed mutagenesis of Asp into Asn, targeted at the DDXXD motif, resulted in significantly decreased enzymatic activity.
Wideband bidirectional MMIC amplifiers for new generation T/R module (2002)

Two novel, bidirectional amplifier approaches conceived and demonstrated with MMICs (monolithic microwave integrated circuits), are presented. These amplifiers are needed in bidirectional transmit/receive (T/R) modules, where close-gain and phase tracking are critical. Excellent gain and phase tracking are inherent in the presented bidirectional amplifier approaches since the same gain elements are used in both the transmit and receive modes. The bidirectional distributed amplifier (BDA) has exhibited better than +or-0.4 dB in gain tracking and +or-2.5 degrees in phase tracking between the transmit and receive modes over a 2-18-GHz band. The bidirectional balanced amplifier (BBA) has shown better than +or-0.4 dB in gain tracking and +or-1.5 degrees in phase tracking over a 6-18-GHz band.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Harkness Henry Lecture from Privy Council to Supreme Court: A Rite of Passage for New Zealand's Legal System (2010)

Professor Margaret Wilson, Professor of Law and Public Policy, Te Piringa - Faculty of Law, University of Waikato delivered the 2010 Harkness Henry Lecture. She spoke about the rite of passage for New Zealand's legal system from Privy Council to Supreme Court.
Predicting Compound Selectivity by Self‐Organizing Maps: Cross‐Activities of Metabotropic Glutamate Receptor Antagonists (2006)

A topological pharmacophore descriptor (CATS) and a self-organizing map (SOM) were used for prediction of multiple receptor interaction of known mGluR antagonists. For a predicted target panel, the tested mGluR ligands exhibited the calculated binding pattern. This virtual screening concept might provide a basis for early recognition of potential side-effects in lead discovery.
Variations of Golomb run-length codes (1992)

The paper deals with coding techniques for encoding the prediction error pattern by introducing an improved version of the Golomb run-length code (RLC), called the double Golomb (DG) code. The improvements of double Golomb over Golomb RLC are compared with that of the multimode Golomb code. >
Prevalence and association of the longus pilus structural gene (lngA) with colonization factor antigens, enterotoxin types, and serotypes of enterotoxigenic Escherichia coli (1995)

Human enterotoxigenic Escherichia coli (ETEC) produces a plasmid-encoded type IV pilus termed longus (for long pilus). Regardless of the geographic origins of ETEC strains, the longus structural gene lngA was found to have the highest level of association with ETEC producing colonization factor antigen (CFA) CFA/II, followed by ETEC producing CFA/I and CFA/IV. ETEC bearing the less prevalent CFA/III and putative colonization factors and ETEC negative for CFA and putative colonization factor also contained lngA-related sequences. lngA was found in a considerable number of ETEC serotypes and was more often associated with ETEC producing heat-stable enterotoxins than with ETEC producing both heat-labile and heat-stable enterotoxins or heat-labile enterotoxin alone. lngA was found more often in strains isolated from children with diarrhea than in strains from healthy children, suggesting an association with intestinal disease. We conclude that longus is a widely distributed antigenic determinant in ETEC that is highly associated with known plasmid-encoded virulence factors, namely, CFAs and enterotoxins. A longus-specific probe may be a helpful epidemiological tool to assist in the identification of ETEC.
Time difference amplifier using closed-loop gain control (2009)

This paper demonstrates a TDA, whose input time difference is amplified into the output time difference. Cross coupled chains of variable delay cells with the same number of stages are applicable for TDA, and the gain is adjusted via DLL-like closed-loop control. The TDA was fabricated using 65nm CMOS and the measurement results shows that the time difference gain is 4.78 at a nominal power supply while the designed gain is 4.0. The gain is stable enough to be less than 1.4% gain shift under ± 10% power supply voltage fluctuation.
Polymers as Catalysts (1980)

Abstract Polymers have been widely used as catalysts or catalyst supports and the various applications can be categorised conveniently into four groups (a) catalysis by soluble linear polymers, (b) catalysis by ion exchange resins, (c) polymer‐supported ‘homogeneous’ metal complex catalysts and (d) polymer‐supported phase transfer catalysts. A brief review of each of these is given, with citation of some of the more recent and important examples which illustrate some of the basic principles involved.
Operational Improvements From In-trail Procedure the in the North Atlantic Organized Track System (2008)

This paper explains the computerized batch processing experiment examining the operational impacts of the introduction of Automatic Dependent Surveillance-Broadcast (ADS-B) equipment and the In-Trail Procedure (ITP) to the North Atlantic Organized Track System (NATOTS). This experiment was conducted using the Traffic Manager (TMX), a desktop simulation capable of simulating airspace environments and aircraft operations. ADS-B equipment can enable the use of new ground and airborne procedures, such as the ITP. The ITP is among the first of these new procedures, which will make use of improved situation awareness in the local surrounding airspace of ADS-B equipped aircraft to enable more efficient oceanic flight level changes. The data collected were analyzed with respect to multiple operationally relevant parameters including fuel burn, request approval rates, and the distribution of fuel savings. This experiment showed that through the use of ADS-B or ADS-B and the ITP that operational improvements and benefits could be achieved.
Problems of Periodization and Terminology in Ukrainian Historiography (1975)

The late Mykola Chubatyi, a leading Ukrainian historian who resided in this country since 1939, recalled in one of his numerous writings ( Ukrains'ka istorychna nauka i ii rozvytok ta dosiahnennia , Philadelphia, 1971) an event involving then Secretary of State Dean Rusk. Asked by one of his associates why he never mentions Ukraine, Rusk answered: “Ukraine is not a statenation and there never existed a Ukrainian state.” Reminded by an insisting friend that this is not the case, because Ukrainians have had their statehood in the Middle Ages and again during the seventeenth century and the Ukrainian SSR is after all a member of the United Nations, Rusk instantly and professorially fired back that Russia always had some problems in the South.
Serological Activity of Protein A of<i>Staphylococcus aureus:</i>the Precipitinogen as an Antigen for Determining Antibodies by the Passive Hemagglutination Test (1968)

Tanned sheep erythrocytes have been considered incapable of sensitization with the precipitinogen of protein A of Staphylococcus aureus, so that the activity of this antigen in serological reactions has so far been studied by means of the agar diffusion test (ADT) only. The precipitinogen of the protein A in this study was found to become attached to the tanned erythrocytes and to sensitize them for the passive hemagglutination test (PHT). It was determined that, in contrast to nonspecific reactivity between normal human serum and the precipitinogen in the ADT, the reaction in the PHT was of specific nature. Of seven species studied, all normal human, dog, and hog sera tested were positive in the PHT. However, the hemagglutinin titers of the sera of the two animal species by far exceeded those of the human sera. The data emphasized the usefulness of the highly sensitive PHT for assaying antibodies to protein A.
Paclitaxel metabolites in human plasma and urine: Identification of 6α‐hydroxytaxol, 7‐epitaxol and taxol hydrolysis products using liquid chromatography/atmospheric‐pressure chemical ionization mass spectrometry (1995)

Abstract Reversed‐phase high‐performance liquid chromatography/mass spectrometry (LC/MS), with an atmospheric‐pressure chemical ionization (APCI) interface, has been applied to the identification of metabolites and derivatives of paclitaxel (taxol) in plasma and urine of patients treated with this new anticancer drug. Protonated molecules with substantial fragmentation were obtained using this ionization technique. The three ion series observed are characteristic of the intact molecule, the taxane ring, and the side chain at C13. Their analysis gives information about chemical modifications of the taxane structure at different positions of the molecule. Urine and plasma extracts were evaluated using the capacity to perform MS analysis directly on the entire effluent from conventional LC columns. Excellent spectra were obtained with 50 pmol of separated compounds in full scan mode. This technique allowed highly sensitive identification of 6α‐hydroxytaxol, the major human biliary metabolite, and of 7‐epitaxol in extracts of plasma and urine from patients. Taxol hydrolysis derivatives were observed for the first time in urine 24 hours after the end of the infusion period. Sensitivity could be increased further using single ion monitoring (SIM) mode, once a target derivative was identified. These results demonstrate that LC/MS with an APCI interface is useful for the characterization and pharmacokinetic analysis of taxoids in biological matrices.
Spot-1, a novel NLS-binding protein that interacts with p53 through a domain encoded by p(CA)n repeats. (1995)

Nuclear Localization Signals (NLS) have been found to mediate the import of proteins into the nucleus. Proteins interacting directly with NLS control the subcellular localization of nucleophilic proteins. The p53 protein is spatially regulated throughout the cell cycle and this regulation has been shown to be dependent on the presence of its NLS sequences. We identified three novel cDNA clones that were isolated from an expression library because they encode polypeptides that bind a synthetic peptide containing the major NLS of p53 (NLS I). These clones were found to share a common domain encoded by p(CA)n repeats; a simple sequence length polymorphism (SSLP). THis is the first report where p(CA)n repeats were found to encode protein. One cDNA clone encodes a full length, 16 kDa protein, designated spot-1, that is represented in cells predominantly as oligomers. spot-1 interacts with the NLS I of p53 through its p(CA)n repeat. Cell fractionation and immunofluorescence analysis demonstrated that spot-1 is a nuclear protein which, in fibroblasts, co-localizes with p53.
Microfluidic platforms for mechanobiology (2013)

Mechanotransduction has been a topic of considerable interest since early studies demonstrated a link between mechanical force and biological response. Until recently, studies of fundamental phenomena were based either on in vivo experiments with limited control or direct access, or on large-scale in vitro studies lacking many of the potentially important physiological factors. With the advent of microfluidics, many of the previous limitations of in vitro testing were eliminated or reduced through greater control or combined functionalities. At the same time, imaging capabilities were tremendously enhanced. In this review, we discuss how microfluidics has transformed the study of mechanotransduction. This is done in the context of the various cell types that exhibit force-induced responses and the new biological insights that have been elucidated. We also discuss new microfluidic studies that could produce even more realistic models of in vivo conditions by combining multiple stimuli or creating a more realistic microenvironment.