gebhart/patrepeval huggingface dataset:
Ex-vivo purging of hematopoietic progenitor cells. (2004)

High-dose chemoradiation therapy with autologous hematopoietic progenitor cell support is effective treatment for patients with a variety of high-risk malignancies. In this setting, tumor cell contamination of the hematopoietic progenitor cell product is a frequently observed problem. The malignant cells in the autograft may be a source of relapse after transplant. Purging the hematopoietic cell grafts ex-vivo may eradicate malignant cells that may contaminate the autologous product. This chapter describes the major purging strategies that have been investigated clinically over the past decade. This investigation includes negative purging with pharmacologic agents and monoclonal antibodies, positive selection with immunoadsorption, immunomagnetic and flow cytometric sorting techniques, ex-vivo culture method, treatment with cytotoxic T cells, and virally mediated purging methods.
Approximate Data Collection in Sensor Networks using Probabilistic Models (2006)

Wireless sensor networks are proving to be useful in a variety of settings. A core challenge in these networks is to minimize energy consumption. Prior database research has proposed to achieve this by pushing data-reducing operators like aggregation and selection down into the network. This approach has proven unpopular with early adopters of sensor network technology, who typically want to extract complete "dumps" of the sensor readings, i.e., to run "SELECT *" queries. Unfortunately, because these queries do no data reduction, they consume significant energy in current sensornet query processors. In this paper we attack the "SELECT " problem for sensor networks. We propose a robust approximate technique called Ken that uses replicated dynamic probabilistic models to minimize communication from sensor nodes to the network’s PC base station. In addition to data collection, we show that Ken is well suited to anomaly- and event-detection applications. A key challenge in this work is to intelligently exploit spatial correlations across sensor nodes without imposing undue sensor-to-sensor communication burdens to maintain the models. Using traces from two real-world sensor network deployments, we demonstrate that relatively simple models can provide significant communication (and hence energy) savings without undue sacrifice in result quality or frequency. Choosing optimally among even our simple models is NPhard, but our experiments show that a greedy heuristic performs nearly as well as an exhaustive algorithm.
Blockchains from a distributed computing perspective (2019)

The roots of blockchain technologies are deeply interwoven in distributed computing.
βig-h3: A Transforming Growth Factor-β-Responsive Gene Encoding a Secreted Protein That Inhibits Cell Attachment <i>In Vitro</i> and Suppresses the Growth of CHO Cells in Nude Mice (1994)

beta ig-h3 is a novel gene first discovered by differential screening of a cDNA library made from A549 human lung adenocarcinoma cells treated with transforming growth factor-beta 1 (TGF-beta 1). It encodes a 683-amino-acid protein containing a secretory signal sequence and four homologous internal domains. Here we show that treatment of several types of cells, including human melanoma cells, human mammary epithelial cells, human keratinocytes, and human fibroblasts, with TGF-beta resulted in a significant increase in beta ig-h3 RNA. A portion of the beta ig-h3 coding sequence was expressed in bacteria, and antisera against the bacterially produced protein was raised in rabbits. This antisera was used to demonstrate that several cell lines secreted a 68-kD beta IG-H3 protein after treatment with TGF-beta. Transfection of beta IG-H3 expression plasmids into Chinese hamster ovary (CHO) cells led to a marked decrease in the ability of these cells to form tumors in nude mice. The beta IG-H3 protein was purified from media conditioned by recombinant CHO cells, characterized by immunoblotting and protein sequencing and shown to function in an anti-adhesion assay in that it inhibited the attachment of A549, HeLa, and WI-38 cells to plastic in serum-free media. Sequencing of cDNA clones encoding murine beta ig-H3 indicated 90.6% conservation at the amino acid level between the murine and human proteins. Finally, the beta ig-h3 gene was localized to human chromosome 5q31, a region frequently deleted in preleukemic myelodysplasia and leukemia. The corresponding mouse beta ig-h3 gene was mapped to mouse chromosome 13 region B to C1, which confirms a region of conservation on human chromosome 5 and mouse chromosome 13. We suggest that this protein be named p68 beta ig-h3.
Synchronizing the Timestamps of Concurrent Events in Traces of Hybrid MPI/OpenMP Applications (2010)

Event traces are helpful in understanding the performance behavior of parallel applications since they allow the in-depth analysis of communication and synchronization patterns. However, the absence of synchronized clocks on most cluster systems may render the analysis ineffective because inaccurate relative event timings may misrepresent the logical event order and lead to errors when quantifying the impact of certain behaviors or confuse the users of time-line visualization tools by showing messages flowing backward in time. In our earlier work, we have developed a scalable algorithm that eliminates inconsistent inter-process timings postmortem in traces of pure MPI applications. Since hybrid programming, the combination of MPI and OpenMP in a single application, is becoming more popular on clusters in response to rising numbers of cores per chip and widening shared-memory nodes, we present an extended version of the algorithm that in addition to message-passing event semantics also preserves and restores shared-memory event semantics.
Inhibitory effects of ursodeoxycholic acid on N-methylnitrosourea-induced colon carcinogenesis and colonic mucosal telomerase activity in F344 rats. (1999)

Bile acids are known to promote colon carcinogenesis. However, one study showed that ursodeoxychlic acid (UDCA) prevented azoxymethane-induced rat colon tumorigenesis. The aim of the present study with 3 sets of experiments was to explore the inhibitory effect of UDCA supplemented in the diet on colon carcinogenesis induced by the intrarectal administration of N-methylnitrosourea (MNU) in F344 rats. In experiment I, 5 rats per group were fed a diet supplemented with 0% (control), 0.4%, 0.08% or 0.016% UDCA or chenodeoxycholic acid (CDCA) for 5 weeks after receiving 3 intrarectal doses of 4 mg MNU in week 1. The formation of colonic aberrant crypt foci (ACFs, preneoplastic lesions) at week 6 showed a 24% and 23% reduction in the 0.4% and 0.08% UDCA groups, respectively, as compared to the control group, while it increased for the 0.4% and 0.08% CDCA groups, and was unaffected in the 0.016% UDCA and CDCA groups. In experiment II based on the results of experiment I, all rats received an intrarectal dose of 2 mg MNU 3 times a week for 3 weeks, and then were administered with 0%, 0.4% or 0.08% UDCA for 27 weeks. At week 30, the incidence of colon tumors in the UDCA groups was significantly lower than that in the control group: 20/50 (40%) and 9/25 (36%) vs. 17/25 (68%). The number of large-sized ACFs with 4 or more ACs showed a 47% and 59% reduction in the normal-appearing mucosa in the UDCA groups as compared to the control group, while the number of small-sized ACFs with 1-3 ACs was similar in all groups. The normal-appearing mucosa showed a noticeable level of telomerase activity (semiquantitative PCR-based TRAP assay) in the control group, and significantly reduced levels in the UDCA groups compared to the control group: 19.8 and 32.7 vs. 71.0 TPG unit in mean value. The colon tumors showed a high level of enzyme activity in both the control and UDCA groups. In experiment III, 6 rats per group were fed a diet supplemented with 0%, or 0.4% UDCA or CDCA for 5 weeks after receiving 3 intrarectal doses of 4 mg MNU in week 1. Two control groups did not receive any treatment with MNU and bile acids. The MNU-treated groups showed significantly elevated levels of colonic mucosal telomerase activity at week 6 as compared to the control group (6.5 TPG unit in mean value). It was noted that both UDCA and CDCA administration reduced the enzyme activity as compared to the group with MNU treatment alone: 24.7 and 25.2 vs. 40.1 TPG unit in mean value. Thus, the present study suggested that orally administered UDCA inhibited the growth of ACFs and the development of carcinomas in the colon of rats treated with MNU. Also, UDCA may suppress MNU-induced telomerase activation in normal-appearing but ACF-containing colon mucosa, and its mechanism appears to be different from that responsible for the anti-tumor promoting action of UDCA.
Novel Ferroelectric Liquid Crystal Mode for Active Matrix Liquid Crystal Display Using Cholesteric–Chiral Smectic C Phase Transition Material (1999)

We propose a novel ferroelectric liquid crystal (FLC) mode which is capable of gray-scale display with an active device such as a thin-film transistor (TFT). This technology is based on the monostable FLC mode, which is obtained from a material with cholesteric–chiral smectic C (Ch–SmC * ) phase transition sequences and by applying a low DC voltage only near the phase transition temperature from Ch to SmC * for making the layer normal direction uniform. The electrooptical response of liquid crystal molecules under AC voltage is asymmetric between plus and minus voltages. It shows characteristics such as low spontaneous polarization ( P S ) value, short response time, small temperature dependence and wide tolerance to cell gap nonuniformity. Furthermore, we made TFT prototype panels using this mode. We could confirm this mode, realizing high-quality moving pictures without blurring based on the nonholding display and good color reproducibility based on the field sequential color method.
Quenching of electron temperature and electron density in ionized physical vapor deposition (1997)

The addition of sputtered metal atoms to a high density plasma results in the ionization of the metal species. The ionized physical vapor deposition technique allows the deposition of metal films from ionic species and is a potential method for the fabrication of integrated circuits with high aspect ratio interconnect features. Maximizing the temperature and density of the plasma electrons is important to optimizing the ionization of metal. The present work reports that the electron temperature and electron density of the plasma decrease with increasing metal density. Direct measurement of electron temperature quenching using a rf compensated Langmuir probe demonstrates a ∼20% decrease in electron temperature due to metal additions of ∼1012 atoms/cm3. The electron density is determined using microwave interferometry and decreases by ∼15% as metal atoms are added to the discharge. A fixed temperature global model, however, indicates that thermalized metal atoms should increase the electron density. Gas heating due to energetic sputtered neutrals is shown to be responsible for the observed decrease in electron density.
Distributed speaker recognition using the ETSI AURORA standard (2002)

Abstract – The ETSI “Aurora ” is a standard for distributed speech recognition over the mobile cellular network. We have investigated the use of the features defined in this standard for speaker recognition, in a text-independent system based on Gaussian Mixture Models (GMM). The application context is distributed speaker recognition for user authentication on the mobile cellular network. We have found that the use of the Aurora parameters would improve the performance compared with the existing alternative which is performing speaker recognition on GSM coded speech. Index Terms—ETSI Aurora, Distributed Speaker Recognition. 1.
Polymers with pendant ferrocenes (2016)

The tailoring of smart material properties is one of the challenges in materials science. The unique features of polymers with pendant ferrocene units, either as ferrocenyl or ferrocenediyl groups, provide electrochemical, electronic, optoelectronic, catalytic, and biological properties with potential for applications as smart materials. The possibility to tune or to switch the properties of such materials relies mostly on the redox activity of the ferrocene/ferricenium couple. By switching the redox state of ferrocenyl units - separately or in a cooperative fashion - charge, polarity, color (UV-vis range) and hydrophilicity of polymers, polymer functionalized surfaces and polymer derived networks (sol-gel) may be controlled. In turn, also the vicinity of such polymers influences the redox behavior of the pendant ferrocenyl units allowing for sensing applications by using polymer bound enzymes as triggering units. In this review the focus is set mainly on the literature of the past five years.
Oxidation of C1 Compounds by Particulate fractions from Methylococcus capsulatus: distribution and properties of methane-dependent reduced nicotinamide adenine dinucleotide oxidase (methane hydroxylase) (1975)

Cell-free particulate fractions of extracts from the obligate methylotroph Methylococcus capsulatus catalyze the reduced nicotinamide adenine dinucleotide (NADH) and O2-dependent oxidation of methane (methane hydroxylase). The only oxidation product detected was formate. These preparations also catalyze the oxidation of methanol and formaldehyde to formate in the presence or absence of phenazine methosulphate with oxygen as the terminal electron acceptor. Methane hydroxylase activity cannot be reproducibly obtained from disintegrated cell suspensions even though the whole cells actively respired when methane was presented as a substrate. Varying the disintegration method or extraction medium had no significant effect on the activities obtained. When active particles were obtained, hydroxylase activity was stable at 0 C for days. Methane hydroxylase assays were made by measuring the methane-dependent oxidation of NADH by O2. In separate experiments, methane consumption and the accumulation of formate were also demonstrated. Formate is not oxidized by these particulate fractions. The effects of particle concentration, temperature, pH, and phosphate concentration on enzymic activity are described. Ethane is utilized in the presence of NADH and O2. The stoichiometric relationships of the reaction(s) with methane as substrate were not established since (i) the presumed initial product, methanol, is also oxidized to formate, and (ii) the contribution that NADH oxidase activity makes to the observed consumption of reactants could not be assessed in the presence of methane. Studies with known inhibitors of electron transport systems indicate that the path of electron flow from NADH to oxygen is different for the NADH oxidase, methane hydroxylase, and methanol oxidase activities.
Free-Fat Injections for the Correction of Hemifacial Atrophy (1989)

Three adult patients with long-standing hemifacial atrophy were treated with repeated free-fat injections at 4- to 8-week intervals. The longest follow-up study to date is 18 months, and following the expected postoperative resorption, no further loss of bulk of injected fat has been observed. On palpation, the feel of the fat is normal, and facial expression is also good. The relative ease of this procedure, which does not entail any scarring, appears to justify more widespread use of free-fat injections to restore facial soft-tissue depressions.
IgE‐associated allergic disorders: recent advances in etiology, diagnosis, and treatment (2016)

IgE-associated allergic diseases belong to the most common inflammatory conditions. Their clinical manifestation ranges from mild symptoms to life-threatening episodes. Often patients experience a reduction in physical and psychologic well-being and suffer from a decreased quality of life due to disease activity. The continuously rising number of people that are affected by an allergic condition indicates an urgent need for better diagnostics and more efficient treatment options. Recent progress in the understanding of pathophysiologic mechanisms underlying IgE-associated allergic disorders has led to the identification of novel therapeutic targets and the development of drug candidates that are currently under evaluation. In this review, we highlight studies and clinical trials, which have helped to gain further insight in the etiology of IgE-associated allergic conditions as well as advances in the development of diagnostic tools and therapeutic approaches recently published in Allergy (European Journal of Allergy and Clinical Immunology).
The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway (1997)

This study has demonstrated that the RBM may be reliably measured by light microscopic methods. This study shows for the first time that the submucosa of the asthmatic airway contains significantly more collagen than normal controls, giving rise to the possibility that airway scar formation may have greater functional implications than has been previously believed from consideration of the RBM alone.
Semantics Meets UX: Mediating Intelligent Indexing of Consumers' Multimedia Collections for Multifaceted Visualization and Media Creation (2008)

Unorganized media collections hinder consumers from fully experiencing and enjoying their visual media. User interfaces can mediate the results of automated indexing by presenting data and interactions that leverage the strengths of individual and combined algorithm results, supporting multifaceted browsing, and enabling user correction in a way that is not disruptive to the userspsila activities. We describe the semantic system demonstration framework (SSDF), a flexible and extensible framework for combining multiple semantic indexing algorithms for consumer photo and video clip collections into one integrated system. We also describe key features of Koi, an SSDF desktop client application with a user interface designed to mediate and leverage the intelligent indexing incorporated in the SSDF server. Together, Koi and SSDF empower users to experience their personal multimedia in novel and sophisticated ways.
A Novel Gene Expression Profile in Lymphatics Associated with Tumor Growth and Nodal Metastasis (2008)

Invasion of lymphatic vessels is a key step in the metastasis of primary tumors to draining lymph nodes. Although the process is enhanced by tumor lymphangiogenesis, it is unclear whether this is a consequence of increased lymphatic vessel number, altered lymphatic vessel properties, or both. Here we have addressed the question by comparing the RNA profiles of primary lymphatic endothelial cells (LEC) isolated from the vasculature of normal tissue and from highly metastatic T-241/vascular endothelial growth factor (VEGF)-C fibrosarcomas implanted in C57BL/6 mice. Our findings reveal significant differences in expression of some 792 genes (i.e., >or=2-fold up- or down-regulated, P <or= 0.05) that code for a variety of proteins including components of endothelial junctions, subendothelial matrix, and vessel growth/patterning. The tumor LEC profile, validated by immunohistochemical staining, is distinct from that of normal, inflammatory cytokine, or mitogen-activated LEC, characterized by elevated expression of such functionally significant molecules as the tight junction regulatory protein endothelial specific adhesion molecule (ESAM), the transforming growth factor-beta coreceptor Endoglin (CD105), the angiogenesis-associated leptin receptor, and the immunoinhibitory receptor CD200, and reduced expression of subendothelial matrix proteins including collagens, fibrillin, and biglycan. Moreover, we show similar induction of ESAM, Endoglin, and leptin receptor within tumor lymphatics in a series of human head and neck and colorectal carcinomas, and uncover a dramatic correlation between ESAM expression and nodal metastasis that identifies this marker as a possible prognostic indicator. These findings reveal a remarkable degree of phenotypic plasticity in cancer lymphatics and provide new insight into the processes of lymphatic invasion and lymph node metastasis.
"Sensorless" control of 4-quadrant-rectifiers for voltage source inverters (VSI) (2004)

This paper presents a novel "sensorless" control strategy for three phase pulsewidth modulated (PWM) power supply rectifiers. The proposed method is based on the voltage oriented control but it does not use any AC-line voltage sensors and does not need accurate parameters of the controlled system. Because of the lack of voltage sensors, the grid voltage has to be estimated. Two voltage estimation methods are used: voltage estimation by instantaneous active and reactive power estimation and a novel voltage estimation by phase tracking. These methods are compared with each other and the experimental results are presented. The control concept was realized on a prototyping system for power electronics control. The influence of the system parameter variations (e.g. line inductance) on the control behavior is investigated. Using the proposed sensorless method it is possible to reduce the sampling frequency of the AC-line currents, because there is no need for synchronization with the PWM-pulse pattern and there is no need for additional test signals. As there is also no need for line side voltage sensors the cost reduction for the PWM rectifier control system is significant.
A distributed table-driven route selection scheme for establishing real-time video channels (2002)

To guarantee the delivery of real-time messages before their deadline, a real-time connection or channel must be established before the transmission of any real-time messages. During this channel-establishment phase, one must first select a route between the source and destination of this channel and then reserve sufficient resources along this route so that the worst-case end-to-end delay over the selected route may not exceed the user-specified delay bound. We propose a table-driven distributed route-selection scheme that is guaranteed to find a "qualified" route, if any, that meets the performance requirement of the requested channel without compromising any of the existing guarantees. The proposed scheme uses the Bellman-Ford shortest path algorithm to build real-time delay tables, and hence, can solve the route-selection problem by a simple table look-up. Several examples are presented to demonstrate the effectiveness of the proposed distributed route-selection scheme.
D1 dopamine receptor immunoreactivity in human and monkey cerebral cortex: predominant and extrasynaptic localization in dendritic spines. (1994)

Antibodies to the D1 dopamine receptor were used to localize this protein in several areas of human and monkey cerebral cortex with light and electron microscopy. In addition to cell body labeling in monkeys, all areas of humans and monkeys had a neuropil label with a laminar distribution predicted by previous D1 receptor autoradiography studies. Using electron microscopy, this neuropil label was seen in numerous dendritic spines, in dendritic shafts, and in occasional axon terminals. While labeled spines were common, they represented only a subset of all cortical spines. Serial sectioning through labeled spines showed that the diaminobenzidine reaction product was usually not at postsynaptic densities but instead was displaced to the side of the large asymmetric (presumed glutamatergic) synapse. Furthermore, most labeled spines did not receive synapses with dopaminergic features, suggesting that many D1 receptors are at extrasynaptic sites, possibly receiving dopamine via diffusion in the neuropil. Similarly, double labeling failed to reveal D1 labeling at synapses of tyrosine hydroxylase immunoreactive axons. Localization to numerous dendritic spines suggests that a primary role of D1 receptors is modulation of glutamatergic input to cortical pyramidal cells.