gebhart/patrepeval huggingface dataset:
Differential privacy for location pattern mining (2011)

One main concern for individuals to participate in the data collection of personal location history records is the disclosure of their location and related information when a user queries for statistical or pattern mining results derived from these records. In this paper, we investigate how the privacy goal that the inclusion of one's location history in a statistical database with location pattern mining capabilities does not substantially increase one's privacy risk. In particular, we propose a differentially private pattern mining algorithm for interesting geographic location discovery using a region quadtree spatial decomposition to preprocess the location points followed by applying a density-based clustering algorithm. A differentially private region quadtree is used for both de-noising the spatial domain and identifying the likely geographic regions containing the interesting locations. Then, a differential privacy mechanism is applied to the algorithm outputs, namely: the interesting regions and their corresponding stay point counts. The quadtree spatial decomposition enables one to obtain a localized reduced sensitivity to achieve the differential privacy goal and accurate outputs. Experimental results on synthetic datasets are used to show the feasibility of the proposed privacy preserving location pattern mining algorithm.
Synthesis of 5H-Benzo[b]carbazole- 6,11-diones from Benzoylindolecarboxylic Acids (2002)

Abs tract -Treatment of 1-benzyl-3-(4-methoxybenzoyl)indole-2-carboxylic acid with phosphorus pentachloride gave the corresponding acid chloride, which was treated with titanium(IV) chloride to afford 9-methoxy-5H-benzo[b]carbazole-6,11dione.In a similar manner, 1-benzenesulfonyl-2-(4-methoxybenzoyl)indole-3carboxylic acid provided 9-methoxy-5H-benzo[b]carbazole-6,11-dione.However, 1-benzyl-3-(4-methoxybenzyl)indole-2-carboxylic acid could be converted to 8-methoxy-5H-benzo[b]carbazole-6,11-dione.5H-Benzo[b]carbazole quinones and their aza analogues (ellipticine quinones) show versatile biological activities and are candidates for treatment of human cancers.1-3 Snieckus 4 and Kelly 5 reported an elegant synthesis of the quinones by reaction of directed ortho-litiated aromatic amides with indole-3-carbaldehyde.Useful syntheses of the 5H-benzo[b]carbazole-6,11-quinones were reported by several groups, but the methods have a limitation of the substituents on the benzene ring.1 ,3,4,6 We showed that 1-benzylindole-2,3-dicarboxylic anhydride (1a) was a useful synthon in the synthesis of murrayaquinone-A, 8 ellipticine, 9 and ellipticine quinone. 10Recently, we reported that reaction of indole-2,3-dicarboxylic anhydride (1) with anisoles provided 1-benzyl-3-(4-methoxybenzoyl)indole-2-carboxylic acids and 1-benzenesulfonyl-2-(4-methoxybenzoyl)indole-3-carboxylic acids.11 In this paper we report a synthesis of 5H-benzo[b]carbazole-6,11-quinones from 1-benzyl-3-(4-methoxybenzoyl)indole-2-carboxylic acid and 1-benzenesulfonyl-2-(4-methoxybenzoyl)indole-3-carboxylic acid.
A review of hydrolifting: A new modality for skin rejuvenation (2017)

The hydrolifting method is a newly introduced antiaging treatment modality. It effectively covers the blind spots of conventional HA injection, such as infraorbital, perioral and hand dorsal wrinkles. However, further investigations are needed to reach a consensus on the basic concepts of treatment, choice of appropriate fillers and optimal technique in hydrolifting.
Injectible dispersion of Δ9-tetrahydrocannabinol in saline using polyvinylpyrrolidone (1971)

Journal Article Injectible dispersion of Δ9-tetrahydrocannabinol in saline using polyvinylpyrrolidone Get access David C Fenimore, David C Fenimore Texas Research Institue of Mental Science, 1300 Moursund, Houston, Texas 77025, USA Search for other works by this author on: Oxford Academic Google Scholar Philip R Loy Philip R Loy Texas Research Institue of Mental Science, 1300 Moursund, Houston, Texas 77025, USA Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 23, Issue 4, April 1971, Page 310, https://doi.org/10.1111/j.2042-7158.1971.tb08667.x Published: 12 April 2011 Article history Received: 13 January 1971 Published: 12 April 2011
Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Enamines (2009)

The first highly enantioselective iridium-catalyzed hydrogenation of cyclic enamines has been developed. This new reaction provided an efficient method for the synthesis of optically active cyclic tertiary amines including natural product crispine A.
Knowledge Mobilisation for Knowledge Whenever and Wherever Needed (2010)

Knowledge mobilisation is a transition from the prevailing knowledge management technology to some innovative methods for knowledge representation, formation and development and for knowledge retrieval and distribution. Knowledge mobilisation also carries the connotation on “knowledge on mobile phones” and this is actually one of the platforms that will be used. Fuzzy ontology replaces classical ontology for knowledge representation. We will show that fuzzy ontology is useful to represent real world knowledge and to give us answers which are sufficiently good for real world situations for which we need sufficiently good knowledge. We demonstrate the knowledge mobilisation approach by showing how amateurs can become wine connoisseurs with support from the technology.
Kinetics of interactions between antibodies and haptens (1975)

Association and dissociation kinetics of antibody-hapten interactions of high affinity and specificity have been determined by newly developed techniques using dextran-coated charcoal for rapid separation of free and antibody-bound hapten. Interactions of 12 combinations of four antibody populations (rabbit digoxin-specific antibody, sheep digoxin-specific antibody, rabbit ouabain-specific antibody, and rabbit digitoxin-specific antibody) with three haptens ([3-H]digoxin, [3-H]ouabain, and [3-H]digitoxin) have been studied in terms of both association and dissociation kinetics, and compared in selected instances with association constants determined under equilibrium conditions. Association rate constants determined under both second-order and pseudo-first-order conditions were found to be similar for all antibody-hapten pairs studied (range 0.87-1.7 times 10-7 M-minus 1 sec- minus 1), and were comparable to values previously estimated for antibodies to dye haptens of markedly lower affinity. In contrast, dissociation rate constants varied markedly from 1.9 times 10- minus 4 to 1.7 times 10- minus 2 sec- minus 1. Ratios of association to dissociation rate constants measured by these methods were in satisfactory agreement with average intrinsic association constants measured under equilibrium conditions. These studies support the concept that the major kinetic variable governing antibody-hapten interactions is the rate of dissociation of the complex, and that the strength of antibody-hapten association is determined principally by the activation energy for dissociation.
Human osteoclasts derive from CD14‐positive monocytes (1999)

Osteoclasts have been defined as calcitonin (CT) and vitronectin (VN) receptor (R) positive, and CD14-, CD11b- and CD11c-negative cells which resorb bone. The aim of this study was to identify the phenotype of the osteoclast precursor. Osteoclasts were generated by co-culturing peripheral blood mononuclear cells (PBMNCS) with the rat osteoblastic UMR 106 cell line. On days 2-4 at least 80% of CTR-positive cells co-expressed CD14, CD11b and CD11c (monocyte markers), but by day 14 < 3.3% expressed these markers. Selection of CD14-positive monocytes from PBMNCS enhanced osteoclastic bone resorption 2-4-fold compared to unfractionated PBMNCS. This study demonstrates that osteoclasts derive largely from CD14-positive monocytes.
Nucleotides 9 to 11 of the influenza A virion RNA promoter are crucial for activity in vitro (1992)

The 12 nucleotide conserved sequence at the 3' end of influenza A virion RNA is sufficient to function as a promoter in vitro. By introducing point mutations in all 12 positions of this promoter in model RNA templates and studying the efficiency of RNA synthesis in vitro, we show that only three nucleotides, residues 9, 10 and 11, are crucial for activity, although other nucleotides play a significant but less important role. Additions or deletions within the promoter are tolerated, resulting in either an increase or a decrease in promoter activity, depending on the mutation introduced; in some cases premature termination is caused. Taking these observations into account, a model for RNA polymerase binding and copying of the promoter is discussed.
Estrogen Metabolism and Excretion in Oriental and Caucasian Women (1994)

Our results indicate that high catechol estrogen formation may be a greater risk factor for breast cancer than high 16 alpha-hydroxylation of estrogens. However, the main risk factor for the Finnish women, as opposed to the Oriental women, may be their higher estrogen levels that result from a higher fat diet, higher estrogen production related to their greater height, and lower fecal estrogen excretion.
Use of personal EEG monitors in a behavioral neuroscience course to investigate natural setting sleep patterns and the factors affecting them in college students. (2011)

Sleep is often a topic of avid interest to college students, yet it is one that does not yield itself well to hands-on, interactive learning modules. Supplementing classroom learning with interactive "real world" laboratory activities provides students with a deeper understanding of behavior and its neural control. The project described here was designed to supplement the teaching of EEGs, sleep and circadian rhythms and involved students in the empirical process from hypothesizing about the factors that affect sleep, to personal data collection, data analysis and writing in the style of a peer-reviewed manuscript. Students enrolled in Behavioral Neuroscience at Connecticut College were provided with a home-based personal EEG monitor used to collect sleep data in their natural sleep setting. Participants recorded sleep data with the use of the ZEO® Personal Sleep Coach system and completed a nightly sleep journal questionnaire for seven nights. The ZEO® system uses EEG patterns to define sleep stages including wakefulness, light, deep and REM sleep. The journal included questions about factors known to affect sleep such as stress, caffeine, academic activity, exercise and alcohol. A class data set was compiled and used by students to perform univariate correlations examining the relationships between ZEO® variables and sleep journal variables. The data set allowed students to choose specific variables to investigate, analyze and write a peer-reviewed style manuscript. Significant class-wide correlations were found between specific sleep stages and behavioral variables suggesting that the ZEO® system is sophisticated yet inexpensive enough to be used as an effective tool in the classroom setting. Overall student feedback on the exercise was positive with many students indicating that it significantly enhanced their understanding of sleep architecture and made them keenly aware of the factors that affect quality of sleep.
Does repeat usage of bevacizumab in patients with progressive recurrent ovarian cancer offer a survival advantage? (2009)

e16510 Background: Many studies show bevacizumab (BEV) has activity in the treatment of recurrent ovarian cancer, especially when combined with cytotoxic chemotherapy. However, it is uncertain whether BEV should be continued if a patient progressives on treatment which includes BEV. Therefore, our objective is to compare response rates (RR), progression-free survival (PFS), and overall survival (OS) between patients who continued on BEV after progression on BEV (BPB) versus patients who were treated with cytotoxic chemotherapy without BEV (no BPB). Methods: All patients who received treatment with BEV (with or without cytotoxic chemotherapy) for recurrent ovarian cancer at a single institution were identified. Patients who received additional therapy after progression on BEV were included. Patients who were treated on GOG 218 or received first-line BEV or had their first BEV therapy discontinued due to side effects from BEV were excluded. RR were assessed using RECIST criteria, CA125 levels, or progressive disease symptoms. PFS was defined as the period from initiation of the treatment regimen until progression or date of last contact. OS was defined as the period from initiation of the second treatment regimen until death or date of last contact. Results: 35 patients met inclusion criteria. The median number of previous chemotherapy regimens was 4 (range 1–8). About 50% of the patients had a CR or PR prior to progressing on BEV. There were 27 patients in the BPB group, and 8 patients in the no BPB group. 13% (1/7) of patients responded to cytotoxic chemo after BEV, and 15% (4/27) of patients responded to repeat treatment with BEV, p = 1. The median PFS for patients in the no BPB group was 4.6 months (95% CI 1.6–5 mo), compared to 4.8 months (2.7–7.5 mo) for patients in the BPB group, p = 0.11. There was no difference in OS, 9.8 months (95% CI 2.73- ∞) versus 8.4 months (95% CI 5.8–15.6 months) p = 0.43 for patients in the no BPB group versus the BPB group. One patient in the BPB group died of a bowel perforation. Conclusions: We offer the first comparison of PFS and OS in patients treated with cytotoxic chemotherapy ± BEV after progression on BEV. After progressing on a BEV regimen, there was no difference in the PFS, OS or RR in those pts treated with or without BEV with an overall OS < 1 year. [Table: see text]
Empirical learning methods for digitized document recognition: an integrated approach to inductive generalization (2002)

A hybrid method of using empirical and supervised learning to acquire knowledge expressed in the form of classification rules is applied to optically scanned documents with the aim of automatic recognition and storage. An expert system devoted to classification recognizes a document as belonging to a class by its layout and the logical structure of a generic printed page. Decision rules for document classification are inferred by inductive generalization. The learning methodology combines a data analysis technique for linearly classifying with a conceptual method for generating disjunctive cover for each class of document.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Dynamic Analysis of Educational Attainment, Occupational Choices, and Job Search (2007)

This paper examines career choices using a dynamic structural model that nests a job search model within a human capital model of occupational and educational choices. Wage growth occurs in the model because workers move between …rms and occupations as they search for suitable job matches and because workers endogenously accumulate …rm and occupation speci…c human capital. Simulations performed using the estimated model reveal that both self-selection in occupational choices and mobility between …rms account for a much larger share of total earnings and utility than the combined e¤ects of …rm and occupation speci…c human capital. Eliminating the gains from matching between workers and occupations would reduce total wages by 31%, eliminating the gains from job search would reduce wages by 19%, and eliminating the e¤ects of …rm and occupation speci…c human capital on wages would reduce wages by only 2.8%. I would like to thank John Pepper, William Johnson, and especially Steven Stern for their invaluable assistance during this project. I thank three anonymous referees and the editor, Petra Todd, for helpful comments and suggestions. This research has bene…ted from discussions with
Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality (2009)

Protease activated receptor 1 (PAR1) signaling can play opposing roles in sepsis, either promoting dendritic cell (DC)-dependent coagulation and inflammation or reducing sepsis lethality due to activated protein C (aPC) therapy. To further define this PAR1 paradox, we focused on the vascular effects of PAR1 signaling. Pharmacological perturbations of the intravascular coagulant balance were combined with genetic mouse models to dissect the roles of endogenously generated thrombin and aPC during escalating systemic inflammation. Acute blockade of the aPC pathway with a potent inhibitory antibody revealed that thrombin-PAR1 signaling increases inflammation-induced vascular hyperpermeability. Conversely, aPC-PAR1 signaling and the endothelial cell PC receptor (EPCR) prevented vascular leakage, and pharmacologic or genetic blockade of this pathway sensitized mice to LPS-induced lethality. Signaling-selective aPC variants rescued mice with defective PC activation from vascular leakage and lethality. Defects in the aPC pathway were fully compensated by sphingosine 1 phosphate receptor 3 (S1P3) deficiency or by selective agonists of the S1P receptor 1 (S1P1), indicating that PAR1 signaling contributes to setting the tone for the vascular S1P1/S1P3 balance. Thus, the activating proteases and selectivity in coupling to S1P receptor subtypes determine vascular PAR1 signaling specificity in systemic inflammatory response syndromes in vivo.
Integrated OTDR/throughput Loss Measurement System For Environmental Testing Of Cabled Optical Fibers (1985)

The presence of transient high-order-mode losses in multi-mode fiber optic cable test samples makes accurate data extrapolation to system lengths difficult. Extensive research has resulted in several methods for launching an equilibrium modal distribution (EMD) into the test sample. Most approaches require coupling the launching apparatus to the sample via a fiber optic splice. However, in many cases, splices disturb the modal distribution thereby reducing the effectiveness of the EMD launcher. In these instances, it is valuable to be able to determine the severity of EMD disruption and correct the problem. A technique employing an OTDR in conjunction with a throughput loss measurement system has recently been developed. The system is used to monitor the quality of EMD transfer into a cable sample prior to testing. Test results illustrating the effectiveness of the integrated system are included.
The Dielectric Lamellar Diffraction Grating (1981)

A rigorous modal theory describing the diffraction properties of a dielectric lamellar grating is presented. The numerical implementation is shown to be suited to modelling the behaviour of high refractive index gratings. This suggests that an approach of this type may be successfully applied to the problem of lossy metallic lamellar gratings.
α‐Glucosidase inhibition (acarbose) fails to enhance secretion of glucagon‐like peptide 1 (7–36 amide) and to delay gastric emptying in Type 2 diabetic patients (2005)

In hyperglycaemic Type 2 diabetic patients, ingestion of acarbose with a mixed test meal failed to enhance GLP-1 release and did not influence gastric emptying.
The Effect of Wound Instillation of a Novel Purified Capsaicin Formulation on Postherniotomy Pain: A Double-Blind, Randomized, Placebo-Controlled Study (2008)

In the setting of a well-defined analgesic protocol standard, VAS AUC analysis and a mixed-effect analysis showed superior analgesia of capsaicin relative to placebo during the first 3-4 days after inguinal hernia repair.
ENVIRONMENTAL JUSTICE: Human Health and Environmental Inequalities (2005)

In this review, we provide an introduction to the topics of environmental justice and environmental inequality. We provide an overview of the dimensions of unequal exposures to environmental pollution (environmental inequality), followed by a discussion of the theoretical literature that seeks to explain the origins of this phenomenon. We also consider the impact of the environmental justice movement in the United States and the role that federal and state governments have developed to address environmental inequalities. We conclude that more research is needed that links environmental inequalities with public health outcomes.
Automatic Analysis of Moving Images (1981)

Cine film and videotape are used to record a variety of natural processes in biology, medicine, meteorology, etc. This paper describes a system which detects and tracks moving objects from these records to obtain meaningful measures of their movements, such as linear and angular velocities. Features of the system are as follows. 1) In order to detect moving objects that are usually blurred, temporal differences of gray values (differences between consecutive frames) are used to separate moving objects from stationary objects, in addition to spatial differences of gray values. 2) The results of previous frames are used to guide feature extraction process of the next frame so that efficient processing of moving pictures which consists of a large number of frames is possible. 3) Uncertain parts in the current frame, such as occluded objects, are deduced using information of previous frames. 4) Misinterpreted or unknown parts in previous frames are reanalyzed using the results of later frames where those parts could be found.
Development of a sensitive assay for detection of replication-competent recombinant lentivirus in large-scale HIV-based vector preparations (2003)

Lentiviral vectors have demonstrated great potential as gene therapy vectors mediating efficient ex vivo and in vivo gene delivery and long-term transgene expression in both dividing and nondividing cells. However, for clinical studies it must be demonstrated that lentiviral vector preparations are safe and not contaminated by replication-competent recombinants related to the parental pathogenic virus. Here we describe a sensitive assay for the detection of replication-competent lentiviruses (RCL) in large-scale preparations of HIV-based lentiviral vectors. This RCL assay for lentiviral vectors is based on the principles used for retroviral vectors, using a highly permissive cell line, C8166-45, for RCL amplification and an appropriate positive control virus to establish the assay sensitivity. The assay is capable of detecting 1 RCL infectious unit in a background of 2.5 x 10(8) transducing units of vector in a single test culture. Statistically representative samples from large-scale lentiviral vector productions were assayed using multiple test cultures for each lot. Overall, a total of 1.4 x 10(10) transducing units of vector from 10 independent 14-liter production lots were screened and no RCL was detected. We propose to implement this assay as a release testing for clinical-grade lentiviral vector preparations intended for gene therapy clinical trials.
Inertial blood plasma separation in a contraction–expansion array microchannel (2011)

Continuous inertial blood plasma separation is demonstrated in a contraction–expansion array microchannel with a low aspect ratio (AR). The separation cutoff value of the particle size can be controlled by modulation of the force balance between inertial lift and Dean drag forces. The modulation is achieved by changing the channel AR at contraction region, which causes the change in magnitudes of the inertial lift forces on the particles. The presented blood plasma separator provides a level of yield and throughput of 62.2% and 1.2 ml/h(∼1.0×108 cells/min), respectively.