gebhart/patrepeval huggingface dataset:
Comparison of Antibody Responses to a Potential Combination of Specific Glycolipids and Proteins for Test Sensitivity Improvement in Tuberculosis Serodiagnosis (2004)

The humoral response to different proteinaceous antigens of Mycobacterium tuberculosis is heterogeneous among patients with active disease, and this has originated in the proposal to use a combination of several specific antigens to find an efficient serodiagnostic test for tuberculosis (TB). However, to date, comparisons of antibody responses to several antigens in the same population have been carried out without consideration of antigenic cell wall glycolipids. In the present study the presence of immunoglobulin G (IgG), IgM, and IgA antibodies to M. tuberculosis glycolipids (sulfolipid I, diacyltrehaloses, triacyltrehaloses, and cord factor) was compared with the response to four commercially available tests based on the 38-kDa protein mixed with the 16-kDa protein or lipoarabinomannan. Fifty-two serum samples from TB patients and 83 serum samples from control individuals (48 healthy individuals and 35 non-TB pneumonia patients) were studied. Three relevant results were obtained. (i) Smear-negative TB patients presented low humoral responses, but the sera which did react principally showed IgA antibodies to some glycolipidic antigens. (ii) TB patients exhibit heterogeneous humoral responses against glycolipidic antigens. (iii) Finally, test sensitivity is improved (from 23 to 62%) when IgG and IgA antibodies are detected together in tests based on different antigens (proteins and glycolipids). We conclude that it is possible to include glycolipidic antigens in a cocktail of specific antigens from M. tuberculosis to develop a serodiagnostic test.
Analysis of Simulation-Driven Numerical Performance Modeling Techniques for Application to Analog Circuit Optimization (2005)

There is promise of efficiency gains in simulator-in-the-loop analog circuit optimization if one uses numerical performance modeling on simulation data to relate design parameters to performance values. However, the choice of modeling approach can impact performance. We analyze and compare these approaches: polynomials, posynomials, genetic programming, feedforward neural networks, boosted feedforward neural networks, multivariate adaptive regression splines, support vector machines, and kriging. Experiments are conducted on a dataset used previously for posynomial modeling, showing the strengths and weaknesses of the different methods in the context of circuit optimization.
Peroxide-initiated vinylsilane grafting: Structural studies on a hydrocarbon substrate (1997)

The peroxide-initiated grafting of vinyltrimethoxysilane (VTMS) onto dodecane has been examined as a model for grafting onto polyethylene. At 160°C, 2% v/v VTMS and 0.08% v/v initiator, the monomer was grafted onto dodecane with a 59% conversion and an average of 2.37 VTMS grafts per dodecane. These values were obtained by separation of the grafted material through reduced pressure distillation then characterization with FTIR and NMR spectroscopy, mass spectrometry, and gel permeation chromatography. NMR studies strongly indicate that the multiple grafts consist predominantly of multiple single grafts rather than homopolymer grafts. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 3517–3525, 1997
Optimized symbol mappings for bit-interleaved coded modulation with iterative decoding (2004)

We investigate bit-interleaved coded modulation with iterative decoding (BICM-ID) for bandwidth efficient transmission, where the bit error rate is reduced through iterations between a multilevel demapper and a simple channel decoder. In order to achieve a significant turbo-gain, the assignment strategy of the binary indices to signal points is crucial. We address the problem of finding the most suitable index assignments to arbitrary, high order signal constellations. A new method based on the binary switching algorithm is proposed that finds optimized mappings outperforming previously known ones.
ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys (2015)

Angiopoietin-like protein 3 (ANGPTL3) is a circulating protein synthesized exclusively in the liver that inhibits LPL and endothelial lipase (EL), enzymes that hydrolyze TGs and phospholipids in plasma lipoproteins. Here we describe the development and testing of a fully human monoclonal antibody (REGN1500) that binds ANGPTL3 with high affinity. REGN1500 reversed ANGPTL3-induced inhibition of LPL activity in vitro. Intravenous administration of REGN1500 to normolipidemic C57Bl/6 mice increased LPL activity and decreased plasma TG levels by ≥50%. Chronic administration of REGN1500 to dyslipidemic C57Bl/6 mice for 8 weeks reduced circulating plasma levels of TG, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C) without any changes in liver, adipose, or heart TG contents. Studies in EL knockout mice revealed that REGN1500 reduced serum HDL-C through an EL-dependent mechanism. Finally, administration of a single dose of REGN1500 to dyslipidemic cynomolgus monkeys caused a rapid and pronounced decrease in plasma TG, nonHDL-C, and HDL-C. REGN1500 normalized plasma TG levels even in monkeys with a baseline plasma TG greater than 400 mg/dl. Collectively, these data demonstrate that neutralization of ANGPTL3 using REGN1500 reduces plasma lipids in dyslipidemic mice and monkeys, and thus provides a potential therapeutic agent for treatment of patients with hyperlipidemia.
Ground-based passive FT-IR spectrometry (2002)

Absorbance and transmittance spectra were acquired with ground-based passive FT-IR spectrometry for industrial stack evaluations and open-air controlled vapor generation experiments. The industrial stack effluents of sulfur dioxide and nitrous oxide were detected from a coal-burning power plant and an acid plant, respectively, with both MWIR and LWIR passive sensors. The controlled open-air experiments relied on only a LWIR sensor. These experiments produced plumes of methanol and ethanol at three and four elevated plume temperatures, respectively. Various vapor concentration pathlength produces of both ethanol and methanol were generated and gravimetrically monitored in the range from 0 to 300 ppm-m. The associated absorbance values for these concentration pathlength products were found to obey Beer's Law for each elevate stack temperature of 125, 150, 175, and 200 degrees C.
Influence of Neutral Axial Stress on Yield and Collapse of Pipe (1975)

Axial stress with zero stress as datum is conventionally used in calculating the influence of tension or compression on yield or collapse of pipe. In this paper, zero stress datum is replaced by “neutral” stress datum. This results in a simpler curve of plasticity, namely a circle, instead of the conventional skewed ellipse. Although equations based on neutral axial stress datum are simpler than equations based on zero axial stress datum, the results of the two methods are equivalent for yielding. On the other hand, the results are different for collapse. Experimental collapse pressures are closer to those calculated on the basis of neutral axial stress datum. Means for making allowance for pressures both inside and outside the pipe are given in the paper. Radial stress is taken into consideration, and, therefore, the treatment is triaxial.
Handbook of Pediatrics (1972)

Handbook of Pediatrics. Fourth Edition. By Henry K. Silver, M.D.; C. Henry Kempe, M.D., and Henry B. Bruyn, M.D. Price, $3.50. Pp. 576. Lange Medical Publications, University Medical Publishers, Box 1215, Los Altos, Calif., 1961. When this handbook first appeared in 1955, a reviewer for the Archives of Diseases in Childhood praised it lavishly. He concluded, On the shelf beside a multivolumed system of pediatrics, one is reminded of Jack the Giant Killer. Amazing value for 3 dollars. Six years later, the fourth edition\p=m-\foronly 50 cents more\p=m-\continuesto warrant acclaim. As the authors specify, their objective is ... a concise and readily available digest of the material necessary for the diagnosis and management of pediatric disorders. It is .
Codon-anticodon interaction studies with trinucleoside diphosphates containing 2-thiouridine, 4-thiouridine, 2,4-diethiouridine, or 2-thiocytidine. (1974)

Abstract 1. Analogues of U-U-U in which uridine residues were replaced by either 2-thiouridine, 4-thiouridine, 2,4-dithiouridine, or 2-thiocytidine were synthesized by enzymatic methods. 2. The dinucleoside phosphates U-N and the trinucleoside diphosphates U-U-N were prepared by ribonuclease A-catalyzed transesterification. 3. The dinucleoside U-N was elongated by using primer-dependent polynucleotide phosphorylase to yield U-N-U. 4. For the synthesis of N-U-U the dinucleoside phosphate G-N, prepared with ribonuclease T 1 , was used as a primer in the polynucleotide phosphorylase-catalyzed reaction to yield G-N-U-U, from which the initial Gp was split off by ribonuclease T 1 . 5. The coding properties of the newly synthesized trinucleoside diphosphates are reported. It follows that Ado·s 2 Urd forms a strong base pair, whereas the base pairs Guo·s 4 Urd, Guo·s 2 Cyd, and Ado·s 4 Urd are weak. No interaction between guanosine and 2-thiouridine or 2,4-dithiouridine could be detected in the binding assay.
Positional identification of variants of Adamts16 linked to inherited hypertension (2009)

A previously reported blood pressure (BP) quantitative trait locus on rat Chromosome 1 was isolated in a short congenic segment spanning 804.6 kb. The 804.6 kb region contained only two genes, LOC306664 and LOC306665. LOC306664 is predicted to translate into A Disintegrin-like and Metalloproteinase with Thrombospondin Motifs-16 (Adamts16). LOC306665 is a novel gene. All predicted exons of both LOC306664 and LOC306665 were sequenced. Non-synonymous variants were identified in only one of these genes, LOC306664. These variants were naturally existing polymorphisms among inbred, outbred and wild rats. The full-length rat transcript of Adamts16 was detected in multiple tissues. Similar to ADAMTS16 in humans, expression of Adamts16 was prominent in the kidney. Renal transcriptome analysis suggested that a network of genes related to BP was differential between congenic and S rats. These genes were also differentially expressed between kidney cell lines with or without knock-down of Adamts16. Adamts16 is conserved between rats and humans. It is a candidate gene within the homologous region on human Chromosome 5, which is linked to systolic and diastolic BP in the Quebec Family Study. Multiple variants, including an Ala to Pro variant in codon 90 (rs2086310) of human ADAMTS16, were associated with human resting systolic BP (SBP). Replication study in GenNet confirmed the association of two variants of ADAMTS16 with SBP, including rs2086310. Overall, our report represents a high resolution positional cloning and translational study for Adamts16 as a candidate gene controlling BP.
Catalytic Transformation of Tall Oil into Biocomponent of Diesel Fuel (2012)

One of the conventional kraft pulp mills produce crude tall oil which is a mixture of free fatty acids, resin acids, sterols, terpenoid compounds, and many others. This study is devoted to the issue of direct transformation of crude tall oil in a mixture with straight-run atmospheric gas oil to liquid fuels using three different commercial hydrotreating catalysts. Diesel fuel production is an alternative to incineration of these materials. High catalytic activity was achieved for all tested catalysts in temperature range 360–380°C, under 5.5 MPa hydrogen pressure and ratio H 2 /feedstock 500–1000 l/l. Crude tall oil can be converted to diesel oil component via simultaneous refining with straight-run atmospheric gas oil on NiMo/Al 2 O 3 and NiW/Al 2 O 3 -zeolite catalysts. All tested catalysts had very good hydrodenitrogenation activity and high liquid yield were at tested conditions.
Cell separations by immunoaffinity partition (2010)

The partition of cells in an aqueous polymer two-phase system composed of dextran T500, polyethylene glycol 8000 and buffer was studied. The effect of various immunoaffinity ligands on erythrocytes and lymphocytes was examined. Separations of rabbit and human erythrocytes were achieved using a combination of monoclonal mouse anti-NN glycophorin IgG with trypan blue-derivatized sheep anti-mouse F[sub c] fragment IgG as well as with a polyacrylamide-derivatized rabbit anti-human erythrocyte IgG (PAA-rochrbc). The PAA-rahrbc was able to completely resolve the two erythrocyte species in a countercurrent distribution (CCD) of 20 transfers. The lymphocyte separation problem was of two sub-lines of a transformed mouse lymphocyte, MBL-2(4.1) and MBL-2(2.6), which differ in the surface densities of an antigen recognized by a rat monoclonal IgG, YE1.48.10. Binding studies showed that at saturation MBL-2(4.1) bound 2.4 x 10⁶ molecules of YE1.48.10. per cell whereas MBL-2(2.6) bound 8 x 10⁵ molecules of YE1.48.10. per cell. This represented an extremely stringent separation problem compared to previous immunoaffinity erythrocyte separations. Attempts to separate the cells by immunoaffinity partition using the following combinations of ligands were not sufficiently successful to achieve useful separations: (a.) PEG 1900-derivatized YE1.48.10. (b.) PEG 1900-derivatized RG7/11.1, a mouse monoclonal IgG specific for rat F[sub c] fragment, and YE1.48.10. (c.) biotin-derivatized YE1.48.10. and PEG-derivatized avidin. However polyacrylamide grafted onto YE1.48.10. produced an effective immunoaffinity ligand, separating MBL-2(4.1) and MBL-2(2.6) on the basis of their antigenic differences. A separation was achieved in 60 CCD transfers.
Copyright protection of still images using self-similar chaotic watermarks (2002)

A spatial domain watermarking algorithm for still images is proposed in this paper. The watermarks are generated by combining scaled versions of 2-D chaotic signals, in order to attain a self-similar structure. In addition, the 2-D chaotic signal generation procedure contains operations which ensure that lowpass watermarks are obtained. Such characteristics (lowpass spectrum, self-similarity) enable robustness against compression, lowpass filtering or, generally, distortions of lowpass nature, as well as, cropping and scaling. An additional advantage of the proposed algorithm is that the detection procedure does not require the original image.
Dataflow parallel database systems and LOGFLOW (2002)

LOGFLOW is a distributed Prolog system running on multi transputer machines and workstation clusters. It is based on the dataflow principle. The most recent database management systems prefer shared nothing architectures and dataflow execution mechanism because of their promising features. LOGFLOW is examined from the database point of view. Both relational and deductive DBMSs can be parallelized by the use of the parallel engine of LOGFLOW.
REVIEWS OF BOOKS (1957)

Journal Article REVIEWS OF BOOKS Get access Songs of the Schubert Circle, 2 vols. pp. 84 & 80. 4s. each. Schubert Songs: Austrian Poets. pp. 36. 2s. 6d. German Words with Translations by E. G. Porter. (Published by the Author, Radcliffe House, Peckham Rye East, London, S.E.15, 1956.) ED ED Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume XXXVIII, Issue 3, July 1957, Pages 287-a–287, https://doi.org/10.1093/ml/XXXVIII.3.287-a Published: 01 July 1957
Dicyclopentadienylzirconium Diborohydride (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDicyclopentadienylzirconium DiborohydrideR. K. Nanda and M. G. H. WallbridgeCite this: Inorg. Chem. 1964, 3, 12, 1798Publication Date (Print):December 1, 1964Publication History Published online1 May 2002Published inissue 1 December 1964https://pubs.acs.org/doi/10.1021/ic50022a039https://doi.org/10.1021/ic50022a039research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Process Simulation of Pulsed Laser Annealing on Epitaxial Ge on Si (2017)

Using a 3D numerical method, temperatures of pulsed laser annealed epi-Ge layers on SOI and bulk Si substrates are simulated. Epi-Ge is phosphorus-doped by in-situ chemical vapor deposition doping. Both the simulated melt depth and the measured sheet electron density of epi-Ge increases as the laser fluence increases. A strong positive correlation is observed between the simulated melt depth of epi-Ge and the measured sheet electron density. The sheet electron density is calculated using the temperature-dependent solid solubility, while the electron concentration for epi-Ge melted during pulsed laser annealing is assumed to be the liquid solubility of phosphorus at melting point. An intermixing between Ge and Si is observed by cross-sectional transmission electron microscopy, when both Si and epi-Ge are melted in the simulation.
Anthropomorphic reasoning about neuromorphic AGI safety (2017)

One candidate approach to creating artificial general intelligence (AGI) is to imitate the essential computations of human cognition. This process is sometimes called ‘reverse-engineering the brain’ and the end product called ‘neuromorphic.’ We argue that, unlike with other approaches to AGI, anthropomorphic reasoning about behaviour and safety concerns is appropriate and crucial in a neuromorphic context. Using such reasoning, we offer some initial ideas to make neuromorphic AGI safer. In particular, we explore how basic drives that promote social interaction may be essential to the development of cognitive capabilities as well as serving as a focal point for human-friendly outcomes.
Intelligent cellular network load balancing using a cooperative negotiation approach (2004)

In this paper, we investigate a novel distributed load balance scheme for cellular networks, which intelligently changes cellular coverage according to the geographic traffic distribution in real time. The performance of the whole cellular network can be improved by contracting the base station antenna pattern around a traffic "hot spot" and expanding adjacent cells' coverage to fill in the loss. A cooperative negotiation approach with semi-smart antennas for cellular network coverage control is described in this paper. By the use of negotiations between adjacent base stations, optimum local coverage agreements can be achieved in the context of the whole cellular network. Results showing the advantage of this technique are also presented.
Molecular approaches to the analysis of nitrate assimilation (1988)

Abstract. The application of molecular approaches such as mutant analysis and recombinant DNA technology, in conjunction with immunology, are set to revolutionize our understanding of the nitrate assimilation pathway. Mutant analysis has already led to the identification of genetic loci encoding a functional nitrate reduction step and is expected to lead ultimately to the identification of genes encoding nitrate uptake and nitrite reduction. Of particular significance would be identification of genes whose products contribute to regulatory networks controlling nitrogen metabolism. Recombinant DNA techniques are particularly powerful and have already allowed the molecular cloning of the genes encoding the apoprotein of nitrate reductase and nitrite reductase. These successes allow for the first lime the possibility to study directly the role of environmental factors such as type of nitrogen source (NO 3 − or NH 4 + ) available to the plant, light, temperature water potential and CO 2 and O 2 tensions on nitrate assimilation gene expression and its regulation at the molecular level. This is an important advance since our current understanding of the regulation of nitrate assimilation is based largely on changes of activity of the component steps. The availability of mutants, cloned genes, and gene transfer systems will permit attempts to manipulate the nitrate assimilation pathway.
<title>Scanning projection grating moire topography</title> (2000)

One problem with moire topography for 3D surface metrology is the so-called 2(pi) -ambiguity limiting the maximum step height difference between two neighboring samples points to be less than half the equivalent wavelength of moire fringes. To cope with the ambiguity problem, a special scheme of scanning moire technique is proposed by resorting to the frequency domain fringe analysis that is in fact originated from white light scanning interferometry. This new more principle of 3D measurement allows determining the absolute height of the surface without information on absolute fringe orders so that largely stepped surfaces are measured with a great improvement in accuracy.
Low-Valent Uranium Iodides: Straightforward Solution Syntheses of UI<sub>3</sub>and UI<sub>4</sub>Etherates (2008)

Uranium turnings react with elemental iodine in diethyl ether at room temperature, with sonication and/or stirring, over a period of days to afford UI 3, UI 4(OEt 2) 2, or UI 4(OBu (n) 2) depending on the stoichiometry or ether solvent. This is the first room temperature, and thus safe and convenient, synthesis of UI 3.
An application of statistics to comparative metagenomics (2006)

The methodology described herein applies statistics to the comparisons of metabolic potential in metagenomes. This analysis reveals those subsystems that are more, or less, represented in the different environments that are compared. These differences in metabolic potential lead to several testable hypotheses about physiology and metabolism of microbes from these ecosystems.
Tolerance to Proinsulin-2 Is Due to Radioresistant Thymic Cells (2006)

Proinsulin is a key Ag in type 1 diabetes, but the mechanisms regulating proinsulin immune tolerance are unknown. We have shown that preproinsulin-2 gene-deficient mice (proins-2(-/-)) are intolerant to proinsulin-2. In this study, we analyzed the mechanisms underlying T cell-mediated tolerance to proinsulin-2 in 129/Sv nonautoimmune mice. The expression of one proinsulin-2 allele, whatever its parental origin, was sufficient to maintain tolerance. The site of proinsulin-2 expression relevant to tolerance was evaluated in thymus and bone marrow chimeras. CD4+ T cell reactivity to proinsulin-2 was independent of proinsulin-2 expression in radiation-sensitive bone marrow-derived cells. A wt thymus restored tolerance in proins-2(-/-) mice. Conversely, the absence of the preproinsulin-2 gene in radioresistant thymic cells was sufficient to break tolerance. Although chimeric animals had proinsulin-2-reactive CD4+ T cells in their peripheral repertoire, they displayed no insulitis or insulin Abs, suggesting additional protective mechanisms. In a model involving transfer to immunodeficient (CD3epsilon(-/-)) mice, naive and proinsulin-2-primed CD4+ T cells were not activated, but could be activated by immunization regardless of whether the recipient mice expressed proinsulin-2. Furthermore, we could not identify a role for putative specific T cells regulating proinsulin-2-reactive CD4+ T in transfer experiments. Thus, proinsulin-2 gene expression by radioresistant thymic epithelial cells is involved in the induction of self-tolerance, and additional factors are required to induce islet abnormalities.