gebhart/patrepeval huggingface dataset:
Effects of active feedback gait retraining to produce a medial weight transfer at the foot in subjects with symptomatic medial knee osteoarthritis (2017)

This study aimed to determine if active feedback gait retraining to produce a medial weight transfer at the foot significantly reduces the knee adduction moment in subjects with medial compartment knee osteoarthritis. Secondarily, changes in peak knee flexion moment, frontal plane knee and ankle kinematics, and center of pressure were investigated. Ten individuals with medial compartment knee osteoarthritis (9 males; age: 65.3 ± 9.8 years; BMI: 27.8 ± 3.0 kg/m<sup>2</sup> ) were tested at self-selected normal and fast speeds in two conditions: Intervention, with an active feedback device attached to the shoe of their more affected leg, and control, with the device de-activated. Kinematics and kinetics were assessed using a motion capture system and force plate. The first peak, second peak, and impulse of the knee adduction moment were significantly reduced by 6.0%, 13.9%, and 9.2%, respectively, at normal speed, with reductions of 10.7% and 8.6% in first peak and impulse at fast speed, respectively, with the active feedback system, with no significant effect on the peak knee flexion moment. Significant reductions in peak varus knee angle and medialized center of pressure in the first half of stance were observed, with reductions in peak varus knee angle associated with reductions in the knee adduction moment. This study demonstrated that active feedback to produce a medial weight-bearing shift at the foot reduces the peaks and impulse of the knee adduction moment in patients with medial compartment knee osteoarthritis. Future research should determine the long-term effect of the active feedback intervention on joint loading, pain, and function. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2251-2259, 2017.
A Scalable Deployable High Gain Antenna - DaHGR (2016)

MMA Design (MMA) has invented and is developing a revolutionary deployable antenna solution providing extremely high areal compaction for future microsatellite missions. Our solution combines the positive attributes of currently fielded antenna systems and will enable performance for microsatellites consistent with today’s large space craft payloads. The MMA patented and patent pending Deployable High Gain Reflectarray (DaHGR) antenna has both a wideband and a narrower band configuration. The antenna architecture is realized using very lightweight flexible membrane substrates incorporating a hoop structure to deploy the membranes and maintain tension. The proposed solution builds on innovations by MMA in extremely lightweight deployable systems specific to large antennas and aerobraking systems. Current state-of-the-art (SOA) Mesh Antennas use ribbed umbrella and hoop structures for deployment. While these are potentially scalable to some extent, they inherently have high parts count and require significant touch labor at a high number of attach points to form the desired mesh surface. These systems have constraints on their stowed volume which present challenges with small launch vehicle fairings and dispensers. The DaHGR sets a new standard for deployable antennas with 1/3rd the parts count, less than 1/5th the volume (with a more favorable/flexible aspect ratio), and ó the cost of current SOA deployable antennas. The DaHGR antenna solution combines the best attributes of successfully flown solutions. It offers advantages in performance, compaction, and simplicity and significantly reduces the development and implementation risk by leveraging proven technologies. A large space-fed reflectarray provides equivalent performance as a conventional reflector for all missions not requiring extremely large bandwidth. Bandwidths achievable by reflectarrays easily support a multitude of mission requirements.
Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats (2017)

Effects of two doses of the anti-diabetic drug, metformin (MF), on hormonal and metabolic levels of serum of non-diabetic male Wistar rats with 1,2-dimethylhydrazine (DMH)-induced colon tumor adenocarcinomas were studied. Carcinogenesis in the animals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulin-like growth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized majority of these changes in DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreased triglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreased endophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiated tumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effects of MF on metabolic homeostasis are critical for preventing colon cancer.
Holoprosencephaly in RSH/Smith-Lemli-Opitz syndrome: Does abnormal cholesterol metabolism affect the function ofsonic hedgehog? (1996)

The RSH/Smith-Lemli-Opitz syndrome (RSH/SLOS) is an autosomal recessive malformation syndrome associated with increased levels of 7-dehydro-cholesterol (7-DHC) and a defect of cholesterol biosynthesis at the level of 3 beta-hydroxy-steroid-delta7-reductase (7-DHC reductase). Because rats exposed to inhibitors of 7-DHC reductase during development have a high frequency of holoprosencephaly (HPE) [Roux et al., 1979], we have undertaken a search for biochemical evidence of RSH/SLOS and other possible defects of sterol metabolism among patients with various forms of HPE. We describe 4 patients, one with semilobar HPE and three others with less complete forms of the HPE sequence, in whom we have made a biochemical diagnosis of RSH/SLOS. The clinical and biochemical spectrum of these and other patients with RSH/SLOS suggests a role of abnormal sterol metabolism in the pathogenesis of their malformations. The association of HPE and RSH/SLOS is discussed in light of the recent discoveries that mutations in the embryonic patterning gene, Sonic Hedgehog (SHH), can cause HPE in humans and that the sonic hedgehog protein product undergoes autoproteolysis to form a cholesterol-modified active product. These clinical, biochemical, and molecular studies suggest that HPE and other malformations in SLOS may be caused by incomplete or abnormal modification of the sonic hedgehog protein and, possible, other patterning proteins of the hedgehog class, a hypothesis testable in somatic cell systems.
Efficient Computation of Voronoi Diagrams (1988)

Voronoi diagrams have advantages of representing geometric information in a compact form which makes them well suited for robot path planning. However, researchers have often found them too complex and inefficient. In this paper, two alternate views of Voronoi diagrams, the Standard [SHAMM75a] and the generalized [KIRKD79] are reviewed. A new method to approximate the Voronoi diagram is developed while showing how all three can be effectively used in applications. Finally, the three methods are compared showing their relative strengths and weaknesses for robot path planning.
An evaluation of the growth promoting effect of the lactoperoxidase system in newborn calves (1981)

ABSTRACT Results are reported from four trials in which neonatal calves were given either whole milk or milk substitute containing the lactoperoxidase system. Trial 1 was a pilot trial conducted in Sweden in which calves given whole milk with the lactoperoxidase system gained significantly more weight than controls ( P < 0·05). Trials 2, 3 and 4 were carried out in successive years at the National Institute for Research in Dairying, using large numbers of newborn, female Friesian calves. In trial 2 a significant positive effect of the lactoperoxidase system with whole milk on live-weight gain was established by 3 weeks of age ( P < 0·05) and sustained until weaning at 5 weeks. There was no significant effect of the lactoperoxidase system for the milk substitute treatment. In trial 3 the whole milk comparison from trial 2 was repeated. There was a significant positive effect of the lactoperoxidase system on the live-weight change after 2 weeks of age only ( P < 0·05). In trial 4 two different methods of activating the lactoperoxidase system were compared for calves given whole milk. There was no effect of either method on the live-weight gain of the calves. However, as the levels of scouring were extremely low for all calves, a comparison of the two methods of activating the lactoperoxidase system was not justified. The combined results from trials 2, 3 and 4 confirmed that the lactoperoxidase system significantly increased the live-weight gain of calves given whole milk, despite the fact that the overall level of mortality and incidence of scouring was low in these trials.
MiR-199a attenuates endometrial stromal cell invasiveness through suppression of the IKK /NF- B pathway and reduced interleukin-8 expression (2011)

MicroRNAs have recently been identified as regulators that modulate target gene expression and are suggested to be involved in the development and progression of endometriosis. This study was undertaken to analyze the expression level of microRNA-199a (miR-199a) in paired ovarian endometrioma and eutopic endometrium from women with endometriosis, and to investigate the contribution of miR-199a to the invasive capability of endometrial stromal cells (ESCs). Cell adhesion, migration and Matrigel invasion assays were carried out to measure the invasiveness of ESCs. Bioinformatics prediction, reporter gene assay, PCR, western blotting and ELISA were performed to identify miR-199a targets and related signaling pathways. The results showed that the expression level of miR-199a was lower in the eutopic endometrium from women with endometriosis, and even lower in the paired ovarian endometrioma, compared with the expression in normal controls. Moreover, ectopic expression of miR-199a attenuated ESC adhesion, migration and invasiveness. MiR-199a targeted and inhibited IkappaB kinase beta (IKKβ) in ESCs. Accompanied by IKKβ reduction, miR-199a suppressed nuclear factor-kappa B (NF-κB) pathway activation and interleukin-8 (IL-8) production in ESCs. All these findings suggest that miR-199a, down-regulated in endometriosis, attenuates the invasive capability of ESCs in vitro partly through IKK/NF-κB pathway suppression and reduced IL-8 expression. In conclusion, miR-199a could be involved in the pathogenesis of endometriosis.
Effect of LVAD Outlet Graft Anastomosis Angle on the Aortic Valve, Wall, and Flow (2012)

Left ventricular assist devices (LVADs), which pump blood from the left ventricle to the aorta are an important therapy option for patients with end-stage cardiovascular diseases. Recent publications show that even with optimized LVADs fatal complications can occur because of the blood deformations around the inflow cannula or through the LVAD outlet graft-aorta anastomosis. This study investigates the effects of the anastomosis geometry on the flow through the aorta, on the pressure and wall shear stress (WSS) distributions on the aortic wall and on the total entropy generation in the anastomosis region. Anastomosis geometry is defined with two angles, one on the coronal plane and the other on the transversal plane. Turbulent flow simulations are performed for each geometry. Results indicate that 3% to 5% of the work given by the LVAD is dissipated because of the viscous losses in the anastomosis region. The entropy generation, as well as the maximum WSS, increases as the inclination angle decreases. Some portion of the blood streaming out of the LVAD conduit flows toward the aortic valve; therefore the reverse-flow region extends up to the aortic valve in some cases, which may be one of the causes of aortic-valve dysfunction. Results of this study provide insight on the importance of the anastomosis geometry on the hemodynamics in the aorta and downstream the aortic valve, stresses on the aortic wall, and viscous losses.
Quality Characteristics of Long‐Grain Rice Milled in Two Commercial Systems (1998)

ABSTRACT Long‐grain rice variety Kaybonnet was milled to three degree of milling (DOM) levels in two commercial milling systems (a single‐break, friction milling system and a multibreak, abrasion and friction milling system) and separated into five thickness fractions. For both milling systems, the surface lipid content (SLC) and protein content of the milled rice varied significantly across kernel thickness fractions. SLC was influenced by DOM level more than by thickness, while the protein content was influenced by thickness more than by DOM level. Particularly at the low DOM levels, the thinnest kernel fraction (<1.49 mm) had higher SLC than the other kernel fractions. Protein content decreased with increasing kernel thickness to 1.69 mm, after which it remained constant. In both milling systems, thinner kernels were milled at a greater bran removal rate as indicated by SLC differences between the low and high DOM levels. For rice milled to a given DOM level, the multibreak system produced fewer brokens than did the single‐break system.
A novel technology mapping method for AND/XOR expressions (2004)

In this paper we propose a novel technology mapping technique for Look-Up Table (LUT) - based Field Programmable Gate Arrays (FPGA). The proposed technology mapping technique is based on AND/exclusive-OR (XOR) expressions. The AND/XOR nature of the proposed techniques can map many important XOR-intensive applications, such as error detecting/correcting, data encryption/decryption, and computer arithmetic circuits efficiently in FPGA. The typical EDA tools deal mainly with AND/OR expressions and therefore are quite inefficient for XOR-intensive applications. We design a new approach and conduct experiments using MCNC benchmark circuits in FPGA environment to demonstrate the effectiveness of our proposed technology mapping technique. The proposed technique is superior to the typical methods with respect to area. When using the proposed technique, the number of CLB is reduced by 67.6% (speed-optimized one) and 57.7% (area-optimized one) and the total number of equivalent gate counts is also reduced by 65.5% compared to the typical methods.
Oxysterol profiles of normal human arteries, fatty streaks and advanced lesions (2001)

The findings confirm that oxysterols are present in fatty streaks and advanced lesions and may arise from different cholesterol oxidation mechanisms, including free radical-mediated oxidation and enzymatic oxidation.
Molecular Catalysts for Water Oxidation (2000)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular Catalysts for Water OxidationMasayuki Yagi and Masao KanekoView Author Information Faculty of Education and Human Sciences, Niigata University, Niigata 950-2181, Japan, and Faculty of Science, Ibaraki University, Mito 310-8512, Japan Cite this: Chem. Rev. 2001, 101, 1, 21–36Publication Date (Web):December 16, 2000Publication History Received25 February 2000Published online16 December 2000Published inissue 1 January 2001https://pubs.acs.org/doi/10.1021/cr980108lhttps://doi.org/10.1021/cr980108lresearch-articleACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views9099Altmetric-Citations621LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysis,Catalysts,Organic reactions,Transition metals,Water oxidation Get e-Alerts
An unusual partial trisomy 13 (1976)

Clinical signs of a partial trisomy of the long arm of a chromosome 13 were present in a boy with a “de novo” translocation 13p+/13q‐.
THE LEGAL SIDE (1980)

DALE J. HYLAND R.N., B.A., is a consultant on aging for the Family Counseling Center, St. Petersburg, Fla. Currently involved in protective services for persons over 60, he founded the Guardian Association of Pinellas County, Inc., and coordinated a committee that developed training and published a handbook for the legal guardian.
82. Anhydrides of polyhydric alcohols. Part XIII. The amino-derivatives of 1 : 4–3 : 6-dianhydro-mannitol, -sorbitol, and -<scp>L</scp>-iditol, and their behaviour towards nitrous acid (1950)

V. G. Bashford and L. F. Wiggins, J. Chem. Soc., 1950, 371 DOI: 10.1039/JR9500000371
[Transcutaneous electrical stimulation for the control of frequency and urge incontinence]. (1983)

To control frequency, urgency and urge incontinence, transcutaneous electrical stimulation was applied to the tibial nerve, the pudendal nerve or the anal sphincter in 79 patients. All patients were refractory to any medications for the control of frequency, nocturia, urgency and urge incontinence from a variety of causes including disk protrusion, Parkinson's disease and idiopathic conditions. The parameters of stimulation were 0.1 to 0.5 msec. duration for each stimulus, frequency 10 to 40 Hz, amplitude 5 to 500 voltage. Cystometrography was repeated during and after electrical stimulation and showed increased bladder capacity, measured at first and/or at maximum desire to void, increased compliance, decreased bladder pressure and/or disappearance of uninhibited contractions in 79% of the patients examined. At least one of these changes was observed in 64, 72 and 85% of the patients who underwent stimulation of the tibial nerve, the pudendal nerve and the anal sphincter, respectively. In some patients inhibition of bladder contraction persisted for more than 2 or 3 days after stimulation. Electromyographic activity of the pelvic floor muscles increased in all of the patients during the stimulation of the pudendal nerve or the anal sphincter, but did not increase and rather decreased during stimulation of the tibial nerve. Urethral pressure measured during electrical stimulation, did not change in many cases. Clinical success was also obtained in 19 of 22 patients who underwent two electrical stimulation program; one was continuous daily use of a portable stimulator, and the other was periodic anal stimulation once or twice a week.(ABSTRACT TRUNCATED AT 250 WORDS)
A Method of News Caption Location Based on C-Mean Clustering and Edge Detection (2008)

Using edge detection to do news video retrieval may cause the caption location inaccurately. A method of news caption location is proposed in the paper, using C-mean clustering to extract the caption, then using vertical differential coefficient and median filter to weaken the image background and noise. Comparing with the existing algorithm, it is simple, it adapts to the complexity background. The experimental results show that the proposed algorithm of news caption location performs well.
Loss of the ??-Isoform of Calcineurin Is Sufficient to Induce Nephrotoxicity and Altered Expression of Transforming Growth Factor-?? (2007)

Our data show that calcineurin-alpha is key to regulation of fibrosis and TGFbeta and loss of this isoform reproduces features of cyclosporine nephrotoxicity in vivo and in vitro. In addition, we show that upregulation of TGFbeta and fibronectin likely result from a shared mechanism, but changes in fibronectin expression are independent of TGFbeta in renal fibroblasts.
Human herpesvirus 7 is a constitutive inhabitant of adult human saliva (1992)

We report the frequent isolation of human herpesvirus 7 from the saliva of healthy adults. Virus isolates recovered from different individuals exhibited minimal restriction enzyme polymorphism, which was mostly confined to heterogeneous (het) sequences in the genome. DNAs of isolates recovered from the same individual over a period of several months showed the same characteristic het fragments, indicating the stability of the het sequences upon virus replication and shedding in vivo. In contrast to the results of previous reports, human herpesvirus 6, the causative agent of roseola infantum, could not be isolated from the saliva specimens, raising questions regarding oral transmission of human herpesvirus 6 and human herpesvirus 7 to young children.
Image Understanding at the GRASP Laboratory (1990)

Research in the GRASP Laboratory has two main themes, parameterized multi-dimensional segmentation and robust decision making under uncertainty. The multi-dimensional approach interweaves segmentation with representation. The data is explained as a best fit in view of parametric primitives. These primitives are based on physical and geometric properties of objects and are limited in number. We use primitives at the volumetric level, the surface level, and the occluding contour level, and combine the results. The robust decision making allows us to combine data from multiple sensors. Sensor measurements have bounds based on the physical limitations of the sensors. We use this information without making a priori assumptions of distributions within the intervals or a priori assumptions of the probability of a given result.
Solid Electrode Chronopotentiometry for Studying the Reaction of Erythrosin on Tinplate (1968)

Chronopotentiometry using a solid tin cathode was used to study the interaction of the food dye erythrosin (2′, 4′, 5′, 7′ -tetra-iodofluorescein) with tin as an example of the application of this technique to the study of some aspects of tinplate corropsion. Erythrosin is reduced by tin in acid solutions to fluorescin, the reduced form of fluorescein, with the exchange of 10 electron/molecule. Erythrosin, inthe concentrations normally used in foods, makes a negligible contribution to the corrosion of tinplate.
Palmitoylputrescine, an Antibiotic Isolated from the Heterologous Expression of DNA Extracted from Bromeliad Tank Water (2004)

Heterologous expression of large fragments of microbial DNA extracted directly from environmental samples (environmental DNA, or eDNA) in easily cultured hosts should provide access to some of the natural products produced by previously uncultured bacteria. The natural product antibiotic palmitoylputrescine (1) was isolated from Escherichia coli transformed with a cosmid (pCSLF16) containing DNA extracted directly from Costa Rican bromeliad tank water. In this report we describe the characterization of this antibiotic and its biosynthetic gene.
Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell? (2018)

This article is part of a themed section on Chemical Biology of Reactive Sulfur Species. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.4/issuetoc.