gebhart/patrepeval huggingface dataset:
EFFECT OF CULTURE SUPERNATANT OF MT‐2 CELLS ON HUMAN IMMUNODEFICIENCY VIRUS‐PRODUCING CELLS, MOLT‐4/HIV<sub>HTLV‐IIIB</sub> CELLS (1988)

The effect of culture supernatant of MT-2 cells on human immunodeficiency virus (HIV)-producing cells, MOLT-4/HIVHTLV-IIIB cells, was examined. As compared to the effect on MOLT-4 cells, parent cells not infected with HIV, a selective cytotoxic/cytostatic effect on MOLT-4/HIVHTLV-IIIB cells was observed 4 days after treatment with up to 640-fold-diluted MT-2 supernatant. Furthermore, under similar conditions, a 2- to 6-fold increase in the number of HIV particles was detected in the culture of MOLT-4/HIVHTLV-IIIB cells 6 hr after treatment. Complete blocking of these effects by anti-lymphotoxin monoclonal antibody, but not by anti-tumor necrosis factor antibody, indicates that these effects of MT-2 supernatant on MOLT-4/HIVHTLV-IIIB cells are attributable to a lymphotoxin-related cytotoxic factor.
Studies of the anionic polymerization of phenylvinylsulfoxide and its copolymer with styrene (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies of the anionic polymerization of phenylvinylsulfoxide and its copolymer with styreneRustom S. Kanga, Thieo E. Hogen-Esch, E. Randrianalimanana, A. Soum, and M. FontanilleCite this: Macromolecules 1990, 23, 19, 4235–4240Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/ma00221a009https://doi.org/10.1021/ma00221a009research-articleACS PublicationsRequest reuse permissionsArticle Views278Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the mechanical equivalent of heat (1851)

Abstract After passing in review the experimental researches of Rum ford, Davy, Dulong, Faraday, and others who have successively discovered facts tending to prove that heat is not a substance, but a mode of force, the author mentions the papers he has already communicated to the Royal Society, and published in the Philosophical Magazine, in which he has endeavoured to show that in the production of heat by the expenditure of force, and vice versâ, in the production of force by the expenditure of heat, a constant relation always subsists between the two. This relation he denominates the “Mechanical Equivalent of Heat,” and the object of the present paper is to advance fresh proofs of its existence, and to give to it the numerical accuracy requisite to fit it as a starting-point for further inquiries. In carrying out the above design, the author has determined the relation of work done to heat produced in the cases of the friction,— 1st, of water; 2nd, of mercury ; and 3rd, of cast iron.
Effects of glycowithanolides from <i>Withania somnifera</i> on an animal model of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats (1995)

Abstract The active principles of Withania somnifera (WS, 20–50 mg/kg, p.o.), consisting of equimolar amounts of sitoindosides. VII–X and withaferin A, were investigated for putative nootropic activity in an experimentally validated Alzheimer's disease (AD) model. The syndrome was induced by ibotenic acid (IA) lesioning of the nucleus basalis magnocellularis (NBM) in rats. Cognitive deficits induced in NMB‐lesioned rats were assessed by attenuation of a learned active avoidance task and a decrease in frontal cortical and hippocampal acetylcholine (ACh) concentrations, choline acetyltransferase (ChAT) activity and muscarinic cholinergic receptor (MCR) binding. IA‐induced NBM lesioning in rats caused a marked cognitive deficit, as evidenced by severe reduction of the learned task, and was accompanied by a significant decrease in frontal cortex and hippocampal ACh levels, ChAT activity and MCR binding. WS (50 mg/kg) significantly reversed both IA‐induced cognitive deficit and the reduction in cholinergic markers after 2 weeks of treatment. The findings validate the medharasayan (promoter of learning and memory) effect of W. somnifera , as has been reported in Ayurveda.
A Convenient Procedure for the Preparation of Reactive Zinc for the Reformatsky Reaction (1991)

Abstract A reactive zinc powder is obtained by addition of ZnCl2 to a lithium dispersion suspended in ether. Reformatsky Reactions with the zinc powder are described.
Cell and Gene-Based Therapies for the Lysosomal Storage Diseases (2006)

Lysosomal storage disorders (LSD) are a group of approximately 40 genetic diseases that are caused by the deficiency of one or more lysosomal enzymes. The incidence of LSD is estimated to be approximately 1 in 7500 live births, which makes this one of the more prevalent groups of genetic diseases in humans. The loss in enzymatic activity leads to the accumulation of undegraded substrates within lysosomes, resulting in distension of the organelle and subsequent cellular malfunction. Although palliative treatments such as enzyme replacement therapy (ERT) or substrate reduction therapy (SRT) have been shown to be effective for some of the LSD such as Gaucher, Fabry and MPS I, they are not available as yet, or ineffective, for a large number of other LSD patients. To fulfill this unmet medical need, gene therapy is being considered as an alternate or adjunctive therapy for this group of disorders. A goal of gene therapy for LSD is to introduce a normal copy of the DNA for the lysosomal enzyme into a depot organ such as the liver or muscle with the intent that this will lead to the sustained production and re-constitution of therapeutic levels of the enzyme in the affected tissues. Here, we review the utility of various gene therapy strategies under consideration for the treatment of the LSD, including viral and non-viral gene transfer approaches, as well as stem cell transplantation.
’’Hot’’ atom interactions with polymer surfaces (1982)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. M. Burkstrand; ''Hot'' atom interactions with polymer surfaces. J. Vac. Sci. Technol. 1 May 1982; 21 (1): 70–73. https://doi.org/10.1116/1.571740 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science and Technology Search Advanced Search |Citation Search
FPRS Student Chapter (1983)

In October, 1982, a new student chapter of FPRS (Forest Products Research Society) was chartered here at ISU. The purpose of starting a new FPRS club in the Forestry Department is to bring together students with related interests. The FPRS chapter at ISIT was developed to work together with the SAP student chapter and the Forestry Club to encourage student involvement with forestry-related activities.
PYRIDINOLINE CROSS-LINKED CARBOXYTERMINAL TELOPEPTIDE OF TYPE I COLLAGEN AS A USEFUL MARKER FOR MONITORING METASTATIC BONE ACTIVITY IN MEN WITH PROSTATE CANCER (2001)

Measuring serum ICTP may be useful for detecting bone metastasis and prostate cancer progression, and may augment PSA and bone scan monitoring of metastatic bone activity.
Improving host swapping using adaptive prefetching and paging notifier (2010)

In a virtualized system, the hypervisor may be forced to reclaim memory by swapping out pages of guest operating systems (OSes) when the regular memory balancing mechanisms, such as page sharing and ballooning, fail to revoke enough memory for reallocation purpose, which always leads to serious performance degradation. In this paper, we introduce Adaptive Swap Prefetcher (ASP) and Host Swapping Notifier (HSN), the effective and lightweight solutions to gracefully reduce the degradation in system performance when host swapping is triggered. ASP smartly prefetches more pages from the host swap file as long as the good spatial locality persists so as to reduce disk transfers. The guest OS will be notified by HSN when the hypervisor evicts pages, which then hides those pages from its memory reclamation routines to eliminate unnecessary guest swapping and to prevent the occurrence of double paging anomaly. Currently ASP and HSN are implemented in KVM, experimental results show that guest performance can be improved by a factory of 1.4x and 2x respectively using ASP and HSN.
The Changing Role of Nursing Unit Managers: A Case of Work Intensification? (2003)

Abstract This paper aims to contribute to growing literature on the intensification of work. It traces the changing role of Nursing Unit Managers (NUMs) in NSW public hospitals since the creation of this position in 1986, using a combination of statewide data and more disaggregated data from a case study of the Division of Medicine in a large public hospital. Empirically, the paper shows that the responsibilities passed to NUMs have steadily expanded and that the amount of work they are required to do is causing many NUMs great distress. Theoretically, the paper confirms the value of Green's distinction between ‘extensive’ and ‘intensive’ work effort and demonstrates the value of Beynon et al. ‘s three-fold classification of the processes leading to work intensification. It is suggested, however, that there is a need to modify the latter classifications to give greater recognition of the fairly obvious fact that much work intensification comes from simple increases in the volume of work—doing more of the same.
Tilt system for Amtrak high speed trainsets (2002)

One of the key technical challenges which had to be overcome to validate the viability of High Speed Rail (HSR) program for the Northeast Corridor (NEC) was how to minimize the travel time between New York and Boston, particularly in the winding, nonelectrified corridor between New Haven and Boston, USA. Electrification, and the use of lightweight, but powerful electric AC traction power cars offered a relatively straight-forward solution to the high speed running and acceleration performance requirements. However, maintaining safe, reliable operation and passenger comfort along the curvy New England right-of-way presented a potentially greater challenge. Following an intensive study which investigated major civil changes required to re-route the railroad, and an alternate approach which combined less aggressive right-of-way upgrades with higher speed/higher cant deficiency operation in curves, the latter approach was chosen. With the selection of this option, it was recognized that the incorporation of an active tilt system would be desirable, and perhaps a necessity. This paper describes the major design features of the first major application of tilt technology to a passenger rail vehicle in the USA and discusses how the tilt system will safely enhance the speed, comfort and overall reliability of the Amtrak HST operation.
Social-aware peer discovery and resource allocation for device-to-device communication (2016)

Device-to-device (D2D) communication has been regarded as a major technology to improve spectrum utilization and to offload the traffic from cellular base station. D2D peer discovery, as a critical procedure, attracts a lot of attentions. Furthermore, combination with the mobile social network (MSN) is an efficient solution to improve the establishment of D2D pairs. However, limited work has been considered about the D2D peer discovery based on MSN. In this paper, we propose an efficient D2D communication scheme for jointly considering D2D peer discovery and resource allocation. Firstly, D2D peer discovery and match mechanism is studied under a D2D communication scenario with MSN. Particularly, residual energy of nodes is taken into account from the concept of green communication. Then based on the matched results, a resource allocation problem is formulated where sub-carries and power resource are jointly allocated. Finally, simulation results are presented to verify effectiveness of our studies.
<b>A theory of syntactic recognition for natural language</b> . By Mitchell P. Marcus. Cambridge, MA: MIT Press, 1980. Pp. 335. $25.00. (1982)

Thesis. 1978. Ph.D.--Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.
Novel Nanostructured Si anode Behavior on Nanorod Array Polymer Substrate (2012)

Abstract not Available.
Determination of flux ionization fraction using a quartz crystal microbalance and a gridded energy analyzer in an ionized magnetron sputtering system (1997)

A diagnostic which combines a quartz crystal microbalance (QCM) and a gridded energy analyzer has been developed to measure the metal flux ionization fraction in a modified commercial dc magnetron sputtering device. The sensor is mounted on a linear motion feedthrough and embedded in a slot in the substrate plane to allow for measuring the uniformity in deposition and ionization throughout the plane of the wafer. Radio-frequency (rf) power is introduced through a coil to ionize the Al atoms. The metal flux ionization fraction at the QCM is determined by comparing the total deposition rate with and without a bias that screens out the ions, but that leaves the plasma undisturbed. By varying the voltage applied to the grids, the plasma potential is determined. At a pressure of 35 mTorr, a magnetron power of 2 kW, and a net rf power of 310±5 W, 78±5% ionization was found.
Development of hot-work tool steel for high-temperature applications (1981)

AbstractAbstractFive different martensitic hot-work tool-steel alloys, two new alloys and three already established ones, have been investigated and compared with respect to decisive material properties. It is thereby demonstrated that a new alloy composition of type 0·4C-2·5Cr-2Mo-1·2V(QRO80) can offer significantly improved material properties, such as enhanced temper resistance and hot yield strength, etc, in combination with moderate alloy-element costs, thus constituting a good example of an alloy optimization for these purposes. Detailed examinations of microstructures have been made by transmission electron microscopy, and differences in mechanical properties between the alloys are discussed with reference to substructural features, such as temper carbides.
Solvent models for protein–ligand binding: Comparison of implicit solvent poisson and surface generalized born models with explicit solvent simulations (2001)

Abstract Solvent effects play a crucial role in mediating the interactions between proteins and their ligands. Implicit solvent models offer some advantages for modeling these interactions, but they have not been parameterized on such complex problems, and therefore, it is not clear how reliable they are. We have studied the binding of an octapeptide ligand to the murine MHC class I protein using both explicit solvent and implicit solvent models. The solvation free energy calculations are more than 10 3 faster using the Surface Generalized Born implicit solvent model compared to FEP simulations with explicit solvent. For some of the electrostatic calculations needed to estimate the binding free energy, there is near quantitative agreement between the explicit and implicit solvent model results; overall, the qualitative trends in the binding predicted by the explicit solvent FEP simulations are reproduced by the implicit solvent model. With an appropriate choice of reference system based on the binding of the discharged ligand, electrostatic interactions are found to enhance the binding affinity because the favorable Coulomb interaction energy between the ligand and protein more than compensates for the unfavorable free energy cost of partially desolvating the ligand upon binding. Some of the effects of protein flexibility and thermal motions on charging the peptide in the solvated complex are also considered. © 2001 John Wiley & Sons, Inc. J Comput Chem 22: 591–607, 2001
Crosslinked micelles as an avenue to smart coreshell nanoparticles for drug delivery (2011)

Nanoparticles are widely proposed to increase the efficacy of drug administration. Self-assembled aggregates such as micelles and vesicles with their core-shell structure are considered advantageous since they can encapsulate high proportions of hydrophobic drugs in the core while maintaining water solubility. However, core-shell particles have often low stability against disassociation. Therefore, we aim at stabilizing the systems by crosslinking of these aggregates and test the behaviour of these stable core-shell nanoparticles in regards to drug loading, drug release and behaviour of these drug carriers in biological evaluation using cancer cell lines. Interestingly,by stabilizing micelles, responsive functional groups can be introduced that responds to changes in the environment. The micelles were in a collapsed state at blood ph value encapsulating the drug safely. However, at ph values between 5 and 6, the nanoparticle starts swelling, pushing out the drug in a fast and efficient manner. This ph responsive behaviour is especially useful considering that once nanoparticles are taken up by the cell they find themselves in an acidic environment of ph 5-5.5. Cell studies confirm that the particles are taken up efficiently by various cancer cell lines and, within 10 min, a substantial amount of drug is released. In summary, a smart nanoparticle system has been created that can encapsulate the drug as long as it circulates in the body, but is effectively swallowed by cancer cells, which subsequently sets off a drug release mechanism.
Effect of different doses of S-adenosyl-L-methionine (SAMe) on nicotinic acid-induced hyperbilirubinaemia in Gilbert's syndrome (1988)

S-adenosyl-L-methionine (SAMe) has been shown to increase hepatocyte membrane fluidity thereby relieving signs of oestrogen-induced cholestasis. S-adenosyl-L-methionine might therefore prove effective in improving the efficiency of the transport of organic anions such as nicotinic acid (NA) and bilirubin which is impaired in Gilbert's syndrome (GS). In this study the effects on the metabolization rate of NA and bilirubin of two dosages of SAMe were evaluated in respect to placebo in ten male inpatients (mean age 24 years, range 16-31) with GS. Each patient received both SAMe (800 and 200 mg/day, respectively) and placebo treatment i.v. over a period of 10 days. The NA test (5.9 mumol/kg b.w. i.v.) was carried out in the same volunteers after each treatment. Unconjugated bilirubin (UCB) levels were significantly lower (p less than 0.01) after 800 mg/day SAMe than after placebo while the lower dosage of SAMe did not affect UCB values. The bilirubin time curve concentration, expressed as area under the curve (AUC), was significantly reduced (p less than 0.01) after 800 mg SAMe in comparison with the values obtained after placebo and 200 mg SAMe. Also plasma NA half-life was significantly reduced (p less than 0.01) by the higher dose of SAMe in respect to placebo and not by the lower dose.
Quantitative studies of ultrasonic vibration potentials in polyelectrolyte slutions (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative studies of ultrasonic vibration potentials in polyelectrolyte slutionsRaoul Zana and Ernest YeagerCite this: J. Phys. Chem. 1967, 71, 11, 3502–3516Publication Date (Print):October 1, 1967Publication History Published online1 May 2002Published inissue 1 October 1967https://pubs.acs.org/doi/10.1021/j100870a024https://doi.org/10.1021/j100870a024research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Unmethylated oligo-DNA containing CpG motifs aggravates collagen-induced arthritis in mice (2000)

Injection of unmethylated oligo-DNA containing CpG motifs aggravated CIA through activation of the Th1-type immune response, suggesting that microbial infection could be one of the mechanisms for aggravation or exacerbation of arthritis or, alternatively, that such infection could be an adjuvant in the induction of arthritis in rheumatoid arthritis.
Insulin Signaling in the Yeast <i>Saccharomyces cerevisiae</i>. 1. Stimulation of Glucose Metabolism and Snf1 Kinase by Human Insulin (1998)

Effects of human insulin on glucose metabolism in the yeast Saccharomyces cerevisiae were studied in this report. Under two conditions of growth limitation (glucose-grown cells during transition to stationary phase or spheroplasts during incubation in synthetic glucose medium), human insulin (10 and 1 microM, respectively) enhanced glycogen accumulation and glycogen synthase activity by 40-60% compared to control cells. Glycogen phosphorylase activity was also increased under the same conditions, but this stimulation was diminished by 35-45% in insulin-treated compared to control cells. Thus, under growth limitation, insulin causes glycogen phosphorylase and glycogen synthase to become more sensitive to inactivation and activation, respectively. In glucose-induced spheroplasts, insulin (1 microM), in addition to glycogen accumulation, led to about 2-fold increases of the rates of ethanol production and glucose oxidation compared to control cells, and the maximal concentration of hexose 6-phosphate was increased by 30-40%. In contrast, glucose transport as well as the levels of the allosteric regulators, fructose 2,6-bisphosphate and cAMP, were not altered at all. Snf1 kinase is assumed to be involved in the regulation of glycogen metabolism in yeast, although it does not seem to be modulated directly by the glucose concentration. Snf1 kinase activity was elevated 5-10-fold in response to insulin both during glucose induction of yeast spheroplasts and during transition to stationary phase of glucose-grown cells. We conclude that Saccharomyces cerevisiae and insulin-sensitive mammalian cells share some parts of the signaling cascades regulating oxidative and nonoxidative glucose metabolism in response to glucose and insulin.