gebhart/patrepeval huggingface dataset:
miR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7 (2016)

The involvement of miR-367 in lung cancer development remains unclear. In the present study, we analyzed the expression of miR-367 in tumor and adjacent tissue samples from 113 patients with non-small cell lung cancer (NSCLC) utilizing real-time PCR. miR-367 expression was significantly upregulated in the cancer tissues compared with non-cancer controls. Based on the median value of the miR-367 expression level, we divided the NSCLC patients into miR-367 high-expression and miR-367 low-expression groups. Overexpression of miR-367 was correlated with a poorer prognosis of NSCLC patients Chi-square (χ2) test showed a significant statistical correlation between tumor size, tumor stage, metastasis and miR-367 expression. Additionally, miR-367 expression was found to be negatively correlated with FBXW7 expression. Based on the above correlations, we performed a series of functional experiments to further confirm the effect of miR-367 on NSCLC. Our results indicated that miR-367 may be involved in the development and progression of NSCLC by promoting proliferation and invasion and impeding apoptosis in NSCLC cells. Furthermore, FBXW7 was identified as a potential target of miR-367, and FBXW7 silencing partially compromised the invasive, proliferative and migratory capacities in the cells with low miR-367 expression. Thus, the miR-367/FBXW7 axis may be involved in the development and progression of NSCLC and may be valuable as a therapeutic target for the treatment of human NSCLC, especially cancers with high invasive potential.
Analysis of Obesity and Hyperinsulinemia in the Development of Metabolic Syndrome: San Antonio Heart Study (2002)

These findings support the National Institutes of Health recommendations for reducing the risk of metabolic syndrome. Adjustment for baseline fasting insulin levels had only a small effect on the ability of anthropometric indices to predict the metabolic syndrome.
Phase Transitions in Soft Matter Induced by Selective Solvation (2011)

Abstract We review our recent studies on selective solvation effects in phase separation in polar binary mixtures with a small amount of solutes. Such hydrophilic or hydrophobic particles are preferentially attracted to one of the solvent components. We discuss the role of antagonistic salt composed of hydrophilic and hydrophobic ions, which undergo microphase separation at water–oil interfaces leading to mesophases. We then discuss phase separation induced by a strong selective solvent above a critical solute density np, which occurs far from the solvent coexistence curve. We also give theories of ionic surfactant systems and weakly ionized polyelectrolytes including solvation among charged particles and polar molecules. We point out that the Gibbs formula for the surface tension needs to include an electrostatic contribution in the presence of an electric double layer.
Progressive Loss of DNA Methylation Releases Epigenetic Gene Silencing From a Tandemly Repeated Maize <i>Myb</i> Gene (2008)

Maize pericarp color1 (p1) gene, which regulates phlobaphene biosynthesis in kernel pericarp and cob glumes, offers an excellent genetic system to study tissue-specific gene regulation. A multicopy p1 allele, P1-wr (white pericarp/red cob) is epigenetically regulated. Hypomethylation of P1-wr in the presence of Unstable factor for orange1 (Ufo1), leads to ectopic pigmentation of pericarp and other organs. The Ufo1-induced phenotypes show incomplete penetrance and poor expressivity: gain of pigmentation is observed only in a subset of plants carrying Ufo1 mutation, and the extent of pigmentation is highly variable. We show that Ufo1 induces progressive hypomethylation of P1-wr repeats over generations. After five generations of exposure to Ufo1, a 30-40% decrease in CG and CNG methylation was observed in an upstream enhancer and an intron region of P1-wr. Interestingly, such hypomethylation correlated with an increase in penetrance of the Ufo1-induced pigmentation phenotype from approximately 27 to 61%. Expressivity of the Ufo1-induced phenotype also improved markedly as indicated by increased uniformity of pericarp pigmentation in the later generations. Furthermore, the poor expressivity of the Uo1 is associated with mosaic methylation patterns of the P1-wr upstream enhancer in individual cells and distinct P1-wr gene copies. Finally, comparison of methylation among different tissues indicated that Ufo1 induces rapid CG and CNG hypomethylation of P1-wr repeats during plant development. Together, these data indicate that the poor penetrance and expressivity of Ufo1-induced phenotypes is caused by mosaicism of methylation, and progressive mitotic hypomethylation leads to improved meiotic heritability of the mutant phenotype. In duplicated genomes like maize, loss of an epigenetic regulator may produce mosaic patterns due to redundancy of epigenetic regulators and their target sequences. We show here that multiple developmental cycles may be required for complete disruption of suppressed epigenetic states and appearance of heritable phenotypes.
On a Complex Recrystallization Texture in 3% Silicon Iron (1960)

Components in a complex primary recrystallization texture, which is a matrix texture for secondary recrystallization to the Goss texture in 3% silicon-iron strip, have been determined by the axis-chart method of Jetter, McHargue, and Williams. The results obtained are compared with former pole-figure results and found to include components not previously resolved or noted. It is found also that the components of the texture explain reasonably well the observed magnetic torque curve of the material.
Fiber optic dynamic light scattering, neither homodyne nor heterodyne (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFiber optic dynamic light scattering, neither homodyne nor heterodyneLeon G. B. Bremer, Luc Deriemaeker, Robert Finsy, Erik Gelade, and Jacques G. H. JoostenCite this: Langmuir 1993, 9, 8, 2008–2014Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/la00032a019https://doi.org/10.1021/la00032a019research-articleACS PublicationsRequest reuse permissionsArticle Views260Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Shapes recognition using the straight line Hough transform: theory and generalization (1992)

A shape matching technique based on the straight line Hough transform (SLHT) is presented. In the theta - rho space, the transform can be expressed as the sum of the translation term and the intrinsic term. This formulation allows the translation, rotation, and intrinsic parameters of the curve to be easily decoupled. A shape signature, called the scalable translation invariant rotation-to-shifting (STIRS) signature, is obtained from the theta - rho space by computing the distances between pairs of points having the same theta value. This signature is invariant to translation and can be easily normalized, and rotation in the image space corresponds to circular shifting of the signature. Matching two signatures only amounts to computing a 1D correlation. The height and location of a peak (if it exists) indicate the similarity and orientation of the test object with respect to the reference object. The location of the test object is obtained, once the orientation is known, by an inverse transform (voting) from the theta - rho space to the x-y plane.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
False-Positive Phencyclidine Immunoassay Results Caused by Venlafaxine and O-Desmethylvenlafaxine (2002)

We recently observed three occurrences of false-positive results for phencyclidine (PCP) on urine samples tested with the Syva® RapidTest d.a.u.® 9 Test Panel (Syva Company, subsidiary of Dade Behring Inc.). The RapidTest d.a.u. 9 device is a single-use, one-step, solid-phase immunochromatographic assay for the qualitative, discrete detection of several drugs/drug metabolites in human urine (1). The urine samples were collected from three different patients who were seen in our Emergency Department within 3–4 weeks after we had implemented the RapidTest device in our laboratory (Danbury Hospital). Because PCP is not a commonly used drug in our locale and the rare positive results have usually been confirmed as false positives, three positive PCP results in such a short time period immediately aroused suspicion.

Patient A was a 52-year-old male with schizoaffective disorder who was admitted to the psychiatry service. Patient B was a 93-year-old female from a nursing home who was admitted with a hip fracture. Patient C was a 50-year-old female admitted for opiate and benzodiazepine overdose. None of these patients had a history of PCP use or presented with symptoms consistent with use of this drug.

Patient A’s urine gave negative results for all other drugs tested with the RapidTest. Patient B’s urine also tested positive for benzodiazepines and barbiturates; these results could be attributed to medications documented in this patient’s medical record: lorazepam, clonazepam, and phenytoin …
Velocity analysis using nonhyperbolic moveout in transversely isotropic media (1997)

Abstract P-wave reflections from horizontal interfaces in transversely isotropic (TI) media have nonhyperbolic moveout. It has been shown that such moveout as well as all time-related processing in TI media with a vertical symmetry axis (VTI media) depends on only two parameters, Vnmo and η. These two parameters can be estimated from the dip-moveout behavior of P-wave surface seismic data. Alternatively, one could use the nonhyperbolic moveout for parameter estimation. The quality of resulting estimates depends largely on the departure of the moveout from hyperbolic and its sensitivity to the estimated parameters. The size of the nonhyperbolic moveout in TI media is dependent primarily on the anisotropy parameter η. An “effective” version of this parameter provides a useful measure of the nonhyperbolic moveout even in v(z) isotropic media. Moreover, effective η, ηeff, is used to show that the nonhyperbolic moveout associated with typical TI media (e.g., shales, with η ≃ 0.1) is larger than that associated with typical v(z) isotropic media. The departure of the moveout from hyperbolic is increased when typical anisotropy is combined with vertical heterogeneity. Larger offset-to-depth ratios (X/D) provide more nonhyperbolic information and, therefore, increased stability and resolution in the inversion for ηeff. The X/D values (e.g., X/D &gt; 1.5) needed for obtaining stability and resolution are within conventional acquisition limits, especially for shallow targets. Although estimation of η using nonhyperbolic moveouts is not as stable as using the dip-moveout method of Alkhalifah and Tsvankin, particularly in the absence of large offsets, it does offer some flexibility. It can be applied in the absence of dipping reflectors and also may be used to estimate lateral η variations. Application of the nonhyperbolic inversion to data from offshore Africa demonstrates its usefulness, especially in estimating lateral and vertical variations in η.
Resistance to Inorganic Salts and Antibiotics Among Sewage‐borne Enterobacteriaceae and Achromobacteriaceae (1976)

Lead‐resistant bacteria isolated from domestic sewage showed simultaneous resistance to other inorganic metals and also antibiotics.
Variability of IgM response in hepatitis C virus infection (1993)

The IgM and IgG antibody response to various hepatitis C virus (HCV) antigens was studied in 8 patients who acquired posttransfusion HCV infection. IgM anti-HCV was detectable in only 4 of these patients, coincident with (1 patient) or later than (3 patients) the IgG anti-HCV response. Seven patients had initially decreasing IgG anti-HCV titres, indicating passive transfer of antibodies from donor to recipient. All 8 patients showed active IgG seroconversion, as demonstrated by increasing IgG anti-HCV titres, on average, 75 days after infection. Five years after infection, all patients were still reactive for IgG anti-HCV antibodies and 7 were positive for HCV RNA by the polymerase chain reaction (PCR). Two of these PCR positive patients were also reactive for IgM anti-HCV. It is concluded that the serology of HCV infection does not follow the classical pattern of IgM response preceding detection of IgG. The IgM response may be absent, late, or persistent after HCV infection. The serological diagnosis of recent HCV infection should be based on the polymerase chain reaction or rising IgG titres in at least 2 sequential patient blood samples.
Active Acoustic Liners enabled by Shape Memory Alloy Technology (2020)

Shorter engine inlets and more compact nacelles are being considered to reduce weight and drag of future commercial airplanes. Such designs may have significantly less area for acoustic treatment. Coupled with engine designs with lower blade passage frequencies and anticipated further stringency for airplane noise certification, the need arises for acoustic liner designs capable of a broad range of attenuation frequencies. With this in mind, a collaboration between Boeing, NASA and Florida State University was formed to develop active acoustic liner technologies to optimize acoustic performance and reduce drag during various stages of flight. One such concept is an active acoustic liner facesheet utilizing shape memory alloy (SMA) technology. A three layer facesheet with an actuated middle layer allows for the facesheet perforation to be sealed when noise attenuation is not required, thereby potentially reducing inlet and aft fan surface drag. This concept also allows for acoustic liner optimization in flight through altering the middle facesheet layer position, allowing for different size perforations to be achieved. This type of acoustic design has been explored in the past for the beneficial acoustic characteristics described above. However, up to this point, there have been limited efforts to develop methods to actuate, manufacture and integrate these designs in practice. This paper highlights the design, fabrication, test, and resulting analysis of the SMA facesheet development process. It will also discuss the successes, challenges, and potential future of active acoustic liner technology. Finally, preliminary impedance data will be shown that illustrates a potential design space for this active liner system.
Poly(ethylene terephthalate) yarn with antibacterial properties (2001)

Poly(ethylene terephthalate) (PET) yarn with grafted poly(acrylic acid) (poly(AA)) was loaded with [6R-[6alpha,7beta(Z)]]-7-[[2-amino-4-thiazolyl)(methoxy-imino)acetyl]aminol-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]-methyl]-5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylic acid (Lendacin), a cephalosporin-type antibiotic. Immobilization of Lendacin was due to ionic interactions. Drug loading was varied from 0.61 to 5.29% wt/wt. The release of Lendacin from the modified PET fibers to water was monitored for 550 h. Variations of Lendacin concentration in water were approximated with a double exponential equation (CL = Cinfinity[a[1 - exp(-k1tau)] + b[1 - exp(-k2tau)]]) describing fast initial burst followed by slow release of Lendacin. In vitro studies revealed that the drug loaded fibers were bioactive against Staphylococcus auras, Escherichia coli, and Pseudomonas aureginosa.
Analysis of Synaptic Growth and Function in<i>Drosophila</i>with an Extended Larval Stage (2012)

The Drosophila larval neuromuscular junction (NMJ) is a powerful system for the genetic and molecular analysis of neuronal excitability, synaptic transmission, and synaptic development. However, its use for studying age-dependent processes, such as maintenance of neuronal viability and synaptic stability, are temporally limited by the onset of pupariation and metamorphosis. Here we characterize larval NMJ growth, growth regulation, structure, and function in a developmental variant with an extended third instar (ETI). RNAi-knockdown of the prothoracicotropic hormone receptor, torso, in the ring gland of developing larvae leaves the timing of first and second instar molts largely unchanged, but triples duration of the third instar from 3 to 9.5 d (McBrayer et al., 2007; Rewitz et al., 2009). During this ETI period, NMJs undergo additional growth (adding >50 boutons/NMJ), and this growth remains under the control of the canonical regulators Highwire and the TGFβ/BMP pathway. NMJ growth during the ETI period occurs via addition of new branches, satellite boutons, and interstitial boutons, and continues even after muscle growth levels off. Throughout the ETI, organization of synapses and active zones remains normal, and synaptic transmission is unchanged. These results establish the ETI larval system as a viable model for studying motor neuron diseases and for investigating time-dependent effects of perturbations that impair mechanisms of neuroprotection, synaptic maintenance, and response to neural injury.
Uniform Cross-Correlation Modified Prime Code for Applications in Synchronous Optical CDMA Communication Systems (2012)

In this paper we have proposed a novel Optical Code Division Multiple Access (OCDMA) prime code, hereby referred to as the “Uniform Cross-Correlation Modified Prime Code (UC-MPC)”. A novel set of formulas is derived for construction of the UC-MPC. Also the correlation properties of the UC-MPC are analyzed and compared with other existing prime code families. Based on this new spreading code, we have analyzed and compared the performances of the following PPM-OCDMA systems (i) without interference cancellation (ii) with interference cancellation and Manchester codes and (iii) with cancellation only. We have found that the proposed UC-MPC has better correlation properties, enhances the bit error rate (BER) and improves the security, as compared with the other existing prime code families.
Methodology for Modeling the Microbial Contamination of Air Filters (2014)

In this paper, we propose a theoretical model to simulate microbial growth on contaminated air filters and entrainment of bioaerosols from the filters to an indoor environment. Air filter filtration and antimicrobial efficiencies, and effects of dust particles on these efficiencies, were evaluated. The number of bioaerosols downstream of the filter could be characterized according to three phases: initial, transitional, and stationary. In the initial phase, the number was determined by filtration efficiency, the concentration of dust particles entering the filter, and the flow rate. During the transitional phase, the number of bioaerosols gradually increased up to the stationary phase, at which point no further increase was observed. The antimicrobial efficiency and flow rate were the dominant parameters affecting the number of bioaerosols downstream of the filter in the transitional and stationary phase, respectively. It was found that the nutrient fraction of dust particles entering the filter caused a significant change in the number of bioaerosols in both the transitional and stationary phases. The proposed model would be a solution for predicting the air filter life cycle in terms of microbiological activity by simulating the microbial contamination of the filter.
Photoactivatable Anthracenes (2014)

Fifteen substituted maleimide cycloadducts of anthracene derivatives were synthesized in one or two steps from available precursors in yields ranging from 32 to 63%. They differ in the nature of the group on the maleimide nitrogen atom and of the substituents on the anthracene platform. In all instances, the introduction of a maleimide bridge across positions 9 and 10 of the anthracene skeleton isolates electronically its peripheral phenylene rings and suppresses its characteristic fluorescence. The cycloadducts with a 4-(dimethylamino)phenyl group on the maleimide nitrogen atom undergo retro-cycloaddition upon ultraviolet illumination with quantum yields ranging from 0.001 to 0.01. This structural transformation restores the aromatic character of the central ring of the oligoacene chromophore and activates its emission with fluorescence quantum yields ranging from 0.07 to 0.85. Thus, this particular choice of building blocks for the construction of photoresponsive compounds can translate into viable operating principles for fluorescence activation and, ultimately, lead to the realization of valuable photoactivatable fluorophores for imaging applications.
Aachen-Keratoprosthesis as Temporary Implant. Case Report on First Clinical Application (2000)

We report the first temporary application of an innovative keratoprosthesis. Its flexibility and good optical qualities allow visualisation and control of intraoperative procedures. This temporary pilot study of the Aachen KPro encourages further investigation of the Aachen KPro as a permanent replacement for a diseased cornea.
Abstract 16097: The Effects of MEDI6012 on Lipoproteins in Familial LCAT Deficiency Patients and a New NMR Method for Quantifying Lipoprotein-X (2017)

Introduction: Lecithin:cholesterol acyltransferase (LCAT), a key enzyme for HDL maturation, catalyzes esterification of cholesterol to cholesteryl ester in plasma. Functional LCAT is absent in patients with Familial LCAT Deficiency (FLD), an autosomal recessive disorder characterized by very low HDL-cholesterol, anemia, nephropathy, and circulating lipoprotein-X (LP-X). LP-X is an abnormal multilamellar particle, enriched in phospholipids and unesterified cholesterol, and is nephrotoxic in mice. Objectives: To characterize the effects of MEDI6012 (rhLCAT) on LP-X in plasma from FLD patients and to compare LP-X measured by agarose gel electrophoresis with a novel assay utilizing nuclear magnetic resonance (NMR) spectroscopy. Methods: We incubated MEDI6012 with fresh plasma from FLD patients and investigated changes in lipoproteins either by Sebia gel electrophoresis or by a novel proton NMR assay on the Vantera analyzer, which detects and quantifies LP-X by exploiting the unique spectral shape and position...