gebhart/patrepeval huggingface dataset:
A Three-Dimensional Human Atrial Model with Fiber Orientation. Electrograms and Arrhythmic Activation Patterns Relationship (2013)

The most common sustained cardiac arrhythmias in humans are atrial tachyarrhythmias, mainly atrial fibrillation. Areas of complex fractionated atrial electrograms and high dominant frequency have been proposed as critical regions for maintaining atrial fibrillation; however, there is a paucity of data on the relationship between the characteristics of electrograms and the propagation pattern underlying them. In this study, a realistic 3D computer model of the human atria has been developed to investigate this relationship. The model includes a realistic geometry with fiber orientation, anisotropic conductivity and electrophysiological heterogeneity. We simulated different tachyarrhythmic episodes applying both transient and continuous ectopic activity. Electrograms and their dominant frequency and organization index values were calculated over the entire atrial surface. Our simulations show electrograms with simple potentials, with little or no cycle length variations, narrow frequency peaks and high organization index values during stable and regular activity as the observed in atrial flutter, atrial tachycardia (except in areas of conduction block) and in areas closer to ectopic activity during focal atrial fibrillation. By contrast, cycle length variations and polymorphic electrograms with single, double and fragmented potentials were observed in areas of irregular and unstable activity during atrial fibrillation episodes. Our results also show: (1) electrograms with potentials without negative deflection related to spiral or curved wavefronts that pass over the recording point and move away, (2) potentials with a much greater proportion of positive deflection than negative in areas of wave collisions, (3) double potentials related with wave fragmentations or blocking lines and (4) fragmented electrograms associated with pivot points. Our model is the first human atrial model with realistic fiber orientation used to investigate the relationship between different atrial arrhythmic propagation patterns and the electrograms observed at more than 43000 points on the atrial surface.
Synthesis of diynes, .alpha.,.beta.-unsaturated monoacids and diacids by the selective palladium(0)-catalyzed and phase transfer catalyzed reactions of vinylic dibromides (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of diynes, .alpha.,.beta.-unsaturated monoacids and diacids by the selective palladium(0)-catalyzed and phase transfer catalyzed reactions of vinylic dibromidesVilmos Galamb, Madhuban Gopal, and Howard AlperCite this: Organometallics 1983, 2, 7, 801–805Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/om50001a003https://doi.org/10.1021/om50001a003research-articleACS PublicationsRequest reuse permissionsArticle Views730Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multiplexed computer-generated waveguide hologram using gratings with different spatial frequencies (1996)

We propose and experimentally demonstrate a multiplexed off-plane computer-generated waveguide hologram, using waveguide gratings with different spatial frequencies. Two spot arrays are produced at different deflection angles and simultaneously focused at different focal lengths above the waveguide. Electron-beam lithography and reactive ion beam etching were used in fabricating this device. The uniformity error and the diffraction efficiency were measured to be approximately 10% and 55%, respectively.
Relationship between γ-ray-induced G <sub>2</sub> /M Delay and Cellular Radiosensitivity (1994)

Seven human and rodent cell lines with markedly differing cellular radiosensitivities were examined by the anti-Br-dUrd antibody and flow cytometric method in order to measure the progression of S phase cells and their accumulation in the G2 phase of the cell cycle after gamma-irradiation. Exponentially growing cells were labelled with 10 microM BrdUrd for 2 h, gamma-irradiated, then washed and cultured at 37 degrees C. At 2-h intervals postirradiation, the cells were harvested and fixed for flow cytometric analysis. Two parameter distributions of BrdUrd content and DNA content were analysed. The time intervals for unirradiated labelled cells to progress from S to G2/M phase were about 450 min for the human squamous cell carcinoma cell lines SCC-12B.2 (D0 = 2.66 Gy), SQ-20B (D0 = 2.39 Gy) and SCC-61 (D0 = 1.07 Gy) as well as for wild-type CHO cells (D0 = 2.62 Gy). After irradiation with 2 Gy, SCC-12B.2, SQ-20B, CHO and human diploid AG1521 cells showed similar small G2/M delays (about 1 h), whereas, a G2/M delay of about 2.2 h occurred in radiosensitive SCC-61 cells and delays of 5.0-7.7 h were observed in two extremely radiosensitive mutant cell strains (human AT homozygote and CHO xrs-5 respectively). When the cells were irradiated with doses yielding similar levels of survival (about 10%), however, the duration of the G2/M delay was generally similar (2-4 h) in all seven cell lines indicating a parallel relationship between radiation-induced G2/M delay and cellular radiosensitivity. These results suggest that the delay time may be related to the level of unrepaired damage present in the cell as it approaches mitosis.
Unitary Joint Standoff Captive Air Training Missile avionics design through operational concepts and functional requirements analysis (1996)

To accurately simulate the Unitary Joint Standoff (JSOW) weapon functions and provide pilots with the most realistic training, the captive air training missile (CATM) avionics design will fully implement well defined operational concepts and functional requirements in terms of flight simulation characteristics, operational functions, pilot feedback, and electronic interfaces. This would provide the Navy, Marines, and Air Force with a single, multi-capable, light weight CATM that consolidates CATM procurement, decreases aircraft turnaround time and increases aircrew training per flight hour.
Fabrication of LED based on III–V nitride and its applications (2003)

Short wavelength LED (TG Purple) based on III-V nitride semiconductors is established in addition to blue and green. This short wavelength LED is realized by adjusting the “indium” chemical content of the well layer. Light output power of “TG Purple” is high and FWHM is narrow. “TG Purple” is applied to light sources of white LED. Combination of “TG Purple” and various phosphors can generate white light with high luminous intensity and good color rendering. “TG Purple” is also applied to light sources of air-purifiers. Air-purifiers have become standard equipments for luxury-car models. Also, several applications of this system are widely utilized in room air conditioners and refrigerators. (© 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
An object based graphical user interface for power systems (1993)

Object-based graphical user interfaces (GUIs) that may be used as flexible, device independent front-ends for power system simulation and control are discussed. An experimental prototype GUI suitable for energy management systems or operator training simulators is described. The GUI is based on the X window environment and uses multiple windows to display differing views of the system and direct mouse manipulations to affect the various power system objects in a consistent fashion. An editing portion of the system allows the dynamic construction of one-line diagrams, although an advanced automatic display generation feature capable of constructing layouts based on database information and sophisticated routing and layout heuristics is also provided. The X window (and C) basis of the implementation of the system provides for its relative platform and operating system independence, and allows the networked operation of multiple platforms running the same functions. The aim of this study is to document the generic features and advantages of such a GUI.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Fragmentation of heparin by enzymes from newly isolated microorganisms. (1991)

In a screening program a number of new heparin (CAS 9005-49-6) degrading microorganisms from soil and water samples from Europe, Asia and Australia were isolated. The new strains were identified as Cytophaga sp. but are distinct from the known heparin degrading organism Cytophaga heparina in various aspects of cell morphology, sugar metabolism and heparin utilization. Analysis of heparin degradation by crude extracts from Cytophaga heparina-, TM5- and SIN1-cells shows that the products obtained from the different strains are distinct. New sulfate cleaving, lytic and hydrolytic enzyme activities were detected and partially purified. Low molecular weight heparins were produced by enzymatic cleavage of unfractionated heparin. The products were separated by gel permeation chromatography and characterized isotachophoretically.
Murine Model of Chemotherapy-Induced Extraintestinal Pathogenic Escherichia coli Translocation (2015)

Escherichia coli is a major cause of life-threatening infections in patients with neutropenia, particularly those receiving chemotherapy for the treatment of cancer. In most cases, these infections originate from opportunistic strains living within the patient's gastrointestinal tract which then translocate to major organ systems. There are no animal models that faithfully recapitulate these infections, and, as such, the host or bacterial factors that govern this process remain unidentified. We present here a novel model of chemotherapy-induced bacterial translocation of E. coli. Oral gavage of BALB/c mice with a clinical isolate of extraintestinal pathogenic E. coli (ExPEC) leads to stable and long-term colonization of the murine intestine. Following the induction of neutropenia with the chemotherapeutic drug cyclophosphamide, ExPEC translocates from the intestine to the lungs, liver, spleen, and kidneys with concomitant morbidity in infected animals. Translocation can also occur in mice bearing mammary tumors, even in the absence of chemotherapy. Translocation of ExPEC is also associated with an increase of the diversity of bacterial DNA detected in the blood. This is the first report of a chemotherapy-based animal model of ExPEC translocation in cancerous mice, a system that can be readily used to identify important virulence factors for this process.
Navigation Assistance Framework for Emergencies. (2013)

Abstract—Emergencies occur every day at unexpected times and impact our lives in unimaginable ways. In any emergency situation, there are two type of victims: direct victims and indirect victims. Both will have their current plans disrupted in order to deal with the emergency. Federal, State, and Local governments have established a 911 system to assist direct victims. However, there is still lack of assistance provided to the indirect victims. In this paper, we propose a Navigation Assistance Framework that allows emergency organizations to provide emergency information that can assist victims navigating out of the emergency area and reaching their intended destinations in a reasonable amount of time. We develop an emergency prototype ERSimMon to simulate this capability in a small scale to show the effectiveness of the proposed solution. In addition, we develop the Emergency Response Application (ERApp) for a smart phone platform, which intercepts the enhanced Commercial Mobile Alert System (CMAS) broadcast message, displays the user’s location with respect to the emergency location on the map and provides navigational assistance and recommend actions to help the user navigate out of ongoing emergencies. I.
Dendritic Cells (DCs) Can Be Successfully Generated From Leukemic Blasts in Individual Patients With AML or MDS (2010)

Myeloid-leukemic cells (AML, MDS, CML) can be differentiated to leukemia-derived dendritic cell [DC (DCleu)] potentially presenting the whole leukemic antigen repertoire without knowledge of distinct leukemia antigens and are regarded as promising candidates for a vaccination strategy. We studied the capability of 6 serum-free DC culture methods, chosen according to different mechanisms, to induce DC differentiation in 137 cases of AML and 52 cases of MDS. DC-stimulating substances were cytokines ("standard-medium", "MCM-Mimic", "cytokine-method"), bacterial lysates ("Picibanil"), double-stranded RNA ["Poly (I:C)"] or a cytokine bypass method ("Ca-ionophore"). The quality/quantity of DC generated was estimated by flow cytometry studying (co) expressions of "DC"antigens, costimulatory, maturation, and blast-antigens. Comparing these methods on average 15% to 32% DC, depending on methods used, could be obtained from blast-containing mononuclear cells (MNC) in AML/MDS cases with a DC viability of more than 60%. In all, 39% to 64% of these DC were mature; 31% to 52% of leukemic blasts could be converted to DCleu and DCleu-proportions in the suspension were 2% to 70% (13%). Average results of all culture methods tested were comparable, however not every given case of AML could be differentiated to DC with 1 selected method. However performing a pre-analysis with 3 DC-generating methods (MCM-Mimic, Picibanil, Ca-ionophore) we could generate DC in any given case. Functional analyses provided proof, that DC primed T cells to antileukemia-directed cytotoxic cells, although an anti-leukemic reaction was not achieved in every case. In summary our data show that a successful, quantitative DC/DCleu generation is possible with the best of 3 previously tested methods in any given case. Reasons for different functional behaviors of DC-primed T cells must be evaluated to design a practicable DC-based vaccination strategy.
The Quest for a Truly Universal Influenza Vaccine (2019)

There is an unmet public health need for a universal influenza vaccine (UIV) to provide broad and durable protection from influenza virus infections. The identification of broadly protective antibodies and cross-reactive T cells directed to influenza viral targets present a promising prospect for the development of a UIV. Multiple targets for cross-protection have been identified in the stalk and head of hemagglutinin (HA) to develop a UIV. Recently, neuraminidase (NA) has received significant attention as a critical component for increasing the breadth of protection. The HA stalk-based approaches have shown promising results of broader protection in animal studies, and their feasibility in humans are being evaluated in clinical trials. Mucosal immune responses and cross-reactive T cell immunity across influenza A and B viruses intrinsic to live attenuated influenza vaccine (LAIV) have emerged as essential features to be incorporated into a UIV. Complementing the weakness of the stand-alone approaches, prime-boost vaccination combining HA stalk, and LAIV is under clinical evaluation, with the aim to increase the efficacy and broaden the spectrum of protection. Preexisting immunity in humans established by prior exposure to influenza viruses may affect the hierarchy and magnitude of immune responses elicited by an influenza vaccine, limiting the interpretation of preclinical data based on naive animals, necessitating human challenge studies. A consensus is yet to be achieved on the spectrum of protection, efficacy, target population, and duration of protection to define a "universal" vaccine. This review discusses the recent advancements in the development of UIVs, rationales behind cross-protection and vaccine designs, and challenges faced in obtaining balanced protection potency, a wide spectrum of protection, and safety relevant to UIVs.
Characterization of Pulsed-Plasma-Polymerized Aromatic Films (1998)

Pulsed plasma polymerization is used to produce aromatic thin films from inductively coupled rf plasmas with benzene, 1,2,4-trifluorobenzene, and hexafluorobenzene as monomers. The effects of aromatic monomer fluorination and duty cycle variation on the resulting films' properties are examined. The surface and bulk properties of the films are determined using Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), static secondary ion mass spectrometry (SIMS), scanning electron microscopy (SEM), static contact angles, and differential scanning calorimetry (DSC). Analysis using these techniques shows a strong dependence of film chemistry and deposition rates on the plasma duty cycle. Systematic changes in film chemistry are observed with the lowest duty cycles producing films containing substituted aromatic rings. On the basis of the SIMS, XPS, and DSC data, films deposited under the optimal pulsed conditions are similar to polystyrene in structure but are more complex, somewhat cross-linked networks. These studies show pulsed plasma polymerization affords high control over film chemistry and properties.
Solid KHT tumor dispersal for flow cytometric cell kinetic analysis (1981)

We used a bacterial neutral protease to disperse KHT solid tumors into single cell suspensions suitable for routine cell kinetic analysis by flow cytometry and for clonogenic cell survival. Neutral protease disaggregation under conditions which would be suitable for routine tumor dispersal was compared with a trypsin/DNase procedure. Cell yield, clonogenic cell survival, DNA distributions of untreated and drug-perturbed tumors, rates of radioactive precursor incorporation during the cell cycle, and preferential cell cycle phase-specific cell loss were investigated. Tumors dispersed with neutral protease yielded approximately four times more cells than those dispersed with trypsin/DNase and approximately a 1.5-fold higher plating efficiency in a semisolid agar system. Quantitative analysis of DNA distributions obtained from untreated and cytosine-arabinoside-perturbed tumors produced similar results with both dispersal procedures. The rates of incorporation of tritiated thymidine during the cell cycle were also similar with neutral protease and trypsin/DNase dispersal. Preferential phase-specific cell loss was not observed with either technique. We find that neutral protease provides good single cell suspensions of the KHT tumor for cell survival measurements and for cell kinetic analysis of drug-induced perturbations by flow cytometry. In addition, the high cell yields facilitate electronic cell sorting where large numbers of cells are often required.
Design, Synthesis, and 3D QSAR of Novel Potent and Selective Aromatase Inhibitors (2004)

The design, synthesis, and biological evaluation of a series of new aromatase inhibitors bearing an imidazole or triazole ring linked to a fluorene (A), indenodiazine (B), or coumarin scaffold (C) are reported. Properly substituted coumarin derivatives displayed the highest aromatase inhibitory potency and selectivity over 17-alpha-hydroxylase/17-20 lyase. The modeling of the aromatase inhibition data by Comparative Molecular Field Analysis (CoMFA/GOLPE 3D QSAR approach) led to the development of a PLS model with good fitting and predictive powers (n = 22, ONC = 3, r(2) = 0.949, s = 0.216, and q(2) = 0.715). The relationship between aromatase inhibition and the steric and electrostatic fields generated by the examined azole inhibitors enables a clear understanding of the nature and spatial location of the main interactions modulating the aromatase inhibitory potency.
Preparation of Refined <scp> <scp>SiC</scp> </scp> Patterns from Imprinting of Partially Cross‐Linked Solid Polycarbosilane (2012)

Bulky SiC composites with refined patterns were successfully fabricated from an imprinting lithography process using solid polycarbosilane ( PCS ) as the ceramic precursor. Structures of the master molds were integrally imprinted to PCS pellets by warm‐pressing of nanoimprinter. Total cracking is effectively prevented by precuring of PCS under air condition. The partially cross‐linked PCS exhibits a degree of thermoplasticity, which facilitates embossing of master molds onto the PCS pellets with pattern sizes ranging from 50 μm to 300 nm. The embossed samples were pyrolyzed up to 1300°C for polymer‐conversion and the prepared patterns can be maintained after the precursor transforms to resultant nanocrystalline SiC composite. Meanwhile, this facile imprinting lithography route is supposed to be capable for the synthesis of SiC patterns with nanosized structures.
Intraventricular Solitary Fibrous Tumor: An Unusual Tumor with Radiological, Ultrastructural, and Immunohistochemical Evaluation: Case Report (2004)

The differential diagnosis of intracranial solitary fibrous tumors includes fibroblastic meningioma, meningeal hemangiopericytoma, neurofibroma, and schwannoma. The differential diagnosis in the present case was greatly helped by the immunohistochemical and ultrastructural findings, along with a disease-free 3.5-year follow-up. These findings are presented with reference to previous reports.
The user's view of SunPict, an extensible visual environment for intermediate-scale procedural programming (2003)

The SunPict environment supports interactive graphical composition and execution of procedural programs. It is able to effectively handle larger user programs than its predecessors, thanks to a combination of efficient algorithms which underlie the implementation, and careful use of traditional visual elements such as color and animation in conjunction with many novel features (including, for example, supplementing textual variable names with simple icons that convey type information, and allowing the runtime action associated with an icon to be specified by means of either an iconic SunPict subprogram or textual code written in a simple Lisp-like dialect). The authors concentrate on the user's view of SunPict. An overview of the environment within the context of previous work is followed by several detailed examples which illustrate what it is like to work in the system. Plans for future enhancements are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>