gebhart/patrepeval huggingface dataset:
Meso‐heterocyclic analogues of 9,10‐dihydroanthracene. XIV. Some indoles and carbazoles derived from phenoxathiin (1978)

Abstract 2‐Aminophenoxathiin undergoes easy condensation with different ω‐bromoketones to give 2‐aroylmethylaminophenoxathiins. These compounds give pyrrolo[2,3‐ b ]phenoxathiins by the Möhlau‐Bischler cyclisation. Some carbazolo[2,1‐ b ]phenoxathiins were also synthesised from 7‐oxo‐7,8,9,10‐tetrahydrobenzo[ b ] phenoxathiin.
Subband coding for image data archiving (1992)

The use of subband coding on image data is discussed. An overview of subband coding is given. Advantages of subbanding for browsing and progressive resolution are presented. Implementations for lossless and lossy coding are discussed. Algorithm considerations and simple implementations of subband are given.
DYPROTO â tools for dynamic business processes (2011)

In this article, we present research results about tools for supporting dynamic business processes. This research work has been conducted in a three-year cooperation between our department and an IT service provider for insurance companies. Our partner’s process management system (PMS) is rather aligned with static processes, whose structure is not changed at process run time. Therefore, we contribute an approach for obtaining dynamic process execution support based on this static PMS by automatically augmenting existent WS-BPEL process definitions and run time data. Dynamically changeable processes are presented to process participants as graphical models by a process model editor. This editor aids process participants with performing dynamic changes in as much as it is aware of explicit and implicit technical and professional process knowledge and detects violations against this knowledge in dynamically changed process instance models. We delineate how explicit process knowledge can be graphically modelled and exploited in automatic checks using OCL-constrained and integrated meta-models. Checks versus explicit knowledge are complemented by checks versus implicit knowledge which is contained in other process definition and process instance models. These checks include process similarity computations based on graph grammar formalisms and tools.
Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome (2015)

Recent evidence suggests immune and inflammatory alterations are important in chronic fatigue syndrome (CFS). This study was done to explore the association of functionally important genetic variants in inflammation and immune pathways with CFS. Peripheral blood DNA was isolated from 50 CFS and 121 non-fatigued (NF) control participants in a population-based study. Genotyping was performed with the Affymetrix Immune and Inflammation Chip that covers 11K single nucleotide polymorphisms (SNPs) following the manufacturer's protocol. Genotyping accuracy for specific genes was validated by pyrosequencing. Golden Helix SVS software was used for genetic analysis. SNP functional annotation was done using SPOT and GenomePipe programs. CFS was associated with 32 functionally important SNPs: 11 missense variants, 4 synonymous variants, 11 untranslated regulatory region (UTR) variants and 6 intronic variants. Some of these SNPs were in genes within pathways related to complement cascade (SERPINA5, CFB, CFH, MASP1 and C6), chemokines (CXCL16, CCR4, CCL27), cytokine signaling (IL18, IL17B, IL2RB), and toll-like receptor signaling (TIRAP, IRAK4). Of particular interest is association of CFS with two missense variants in genes of complement activation, rs4151667 (L9H) in CFB and rs1061170 (Y402H) in CFH. A 5' UTR polymorphism (rs11214105) in IL18 also associated with physical fatigue, body pain and score for CFS case defining symptoms. This study identified new associations of CFS with genetic variants in pathways including complement activation providing additional support for altered innate immune response in CFS. Additional studies are needed to validate the findings of this exploratory study.
Invertase & invertase inhibitor in potato (1961)

The pattern of changes in sugar composition which occur when potatoes are stored at low temperatures or are irradiated (18, 19) suggests that the reducing sugars mnay arise as the consequence of the hydrolytic action of invertase on sucrose. During cold temperature storage there is a rapid increase in sucrose content followed bh an increase in redlucing sugars relative to the sucrose content. Furthermore a survey of the literatur-e indicates that, for many varieties of potatoes, the ratio of glucose to fructose is close to unity (luring at least part of the time of storage (17). If invertase is indleed a factor in the accumulation of reducing sugars, information concerning the characteristics of this enzyme and the inhibitor here reported could conceivably lead to nmeans for controlling the reducing sugar content of potatoes (20). The literature on potato invertase is rather sparse. Tn 1903, Kastle and Clark (9) detected invertase in sprouted but not in unsprouted potatoes. In 1928, MlcGuire and Falk (13) showed that the invertase action of potato juice was higher at pH 4 than at pH 5 and 6. Denny et al (5) found that the invertase activity of potato juice from tubers treated with ethylene chlorohvdrin was significantly greater than that fronm untreated controls. A few reports have suggested that the level of invertase activity depends on the elemental nutrition of the plant [potassium (24), boron (4), chlorine & sulfur (10)1. Bois and Savary (3) and MIcCready (12) in more recent years have detected invertase in potatoes, although the latter author could fin(d activity only in sprouted andl not in unsprouted tubers. The presenlt paper describes our experience in attempting to (letect invertase in crude potato macerates. In general, the results confirnm the scattered findings of the older literature but also point to the presence of an endogenous inhibitor of the enzymiie. A preliminary report of some of the present results has been publishedl elsewlhere (21).
Identification of Novel Surface Proteins of<i>Anaplasma phagocytophilum</i>by Affinity Purification and Proteomics (2007)

Anaplasma phagocytophilum is the etiologic agent of human granulocytic anaplasmosis (HGA), one of the major tick-borne zoonoses in the United States. The surface of A. phagocytophilum plays a crucial role in subverting the hostile host cell environment. However, except for the P44/Msp2 outer membrane protein family, the surface components of A. phagocytophilum are largely unknown. To identify the major surface proteins of A. phagocytophilum, a membrane-impermeable, cleavable biotin reagent, sulfosuccinimidyl-2-[biotinamido]ethyl-1,3-dithiopropionate (Sulfo-NHS-SS-Biotin), was used to label intact bacteria. The biotinylated bacterial surface proteins were isolated by streptavidin agarose affinity purification and then separated by electrophoresis, followed by capillary liquid chromatography-nanospray tandem mass spectrometry analysis. Among the major proteins captured by affinity purification were five A. phagocytophilum proteins, Omp85, hypothetical proteins APH_0404 (designated Asp62) and APH_0405 (designated Asp55), P44 family proteins, and Omp-1A. The surface exposure of Asp62 and Asp55 was verified by immunofluorescence microscopy. Recombinant Asp62 and Asp55 proteins were recognized by an HGA patient serum. Anti-Asp62 and anti-Asp55 peptide sera partially neutralized A. phagocytophilum infection of HL-60 cells in vitro. We found that the Asp62 and Asp55 genes were cotranscribed and conserved among members of the family Anaplasmataceae. With the exception of P44-18, all of the proteins were newly revealed major surface-exposed proteins whose study should facilitate understanding the interaction between A. phagocytophilum and the host. These proteins may serve as targets for development of chemotherapy, diagnostics, and vaccines.
Modern Carbon–Fluorine Bond Forming Reactions for Aryl Fluoride Synthesis (2014)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTModern Carbon–Fluorine Bond Forming Reactions for Aryl Fluoride SynthesisMichael G. Campbell and Tobias Ritter*View Author Information Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States*E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 2, 612–633Publication Date (Web):December 4, 2014Publication History Received10 July 2014Published online4 December 2014Published inissue 28 January 2015https://doi.org/10.1021/cr500366bCopyright © 2014 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views18079Altmetric-Citations578LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (4 MB) Get e-AlertsSUBJECTS:Anions,Halogenation,Hydrocarbons,Reagents,Salts Get e-Alerts
Web based tool for resource allocation in multiple mass casualty incidents (2009)

In this paper we introduce a web based real time resource allocation tool that can assist the incident commanders and resource managers in the complex task of resource allocation and transportation for multiple simultaneous incidents that occur in close geographical proximity. The tool takes real time inputs like the location of emergency sites and damaged routes from Google Maps, generates an optimal transportation plan so that emergency sites with highest priorities for a resource are assigned the resources in the least amount of time. The optimal solution is presented graphically using Google Maps. Our solution can be used for emergency resource allocation at both the initial response stage and later stages.
Physiology of the Human Body (1979)

Physiology of the human body , Physiology of the human body , کتابخانه دیجیتال جندی شاپور اهواز
Validation of Transcranial Doppler With Computed Tomography Angiography in Acute Cerebral Ischemia (2007)

Bedside TCD examination yields satisfactory agreement with urgent brain CTA in the evaluation of patients with acute cerebral ischemia. TCD can provide real-time flow findings that are complementary to information provided by CTA.
Immunological profile of peripheral blood lymphocytes and monocytes/macrophages in Kawasaki disease (2005)

Kawasaki disease (KD) is an acute illness of early childhood characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and nonsuppurative lymphadenopathy. The histopathological findings in KD comprise panvasculitis with endothelial necrosis, and the infiltration of mononuclear cells into small and medium-sized blood vessels. The levels of many proinflammatory cytokines, chemokines and adhesion molecules can be elevated in sera from children with KD at the acute stage. Although many immunological studies on KD involving peripheral blood have been reported, the data obtained remain controversial. This review focuses on the immune response of peripheral blood lymphocytes and monocytes/macrophages during acute KD.
PATHWAY FOR THE DISSIMILATION OF ITACONIC AND MESACONIC ACIDS (1961)

Brightman, Vernon (The University of Chicago, Chicago), and William R. Martin. Pathway for the dissimilation of itaconic and mesaconic acids. J. Bacteriol. 82:376-382. 1961.-Studies on the oxidation of itaconic and mesaconic acids by a Pseudomonas sp., adapted to utilize either of these acids as a sole carbon source, have provided evidence for a pathway converting both itaconate and mesaconate to succinate. A metabolic interconversion of itaconate, mesaconate, and citramalate has also been demonstrated by whole cell and cell-free enzyme studies. Succinate derived from methylene-labeled itaconate was found to be labeled in the inside carbon atoms, a fact which indicates that the branched chain compound was converted into a straight chain molecule by a shift of the methylene carbon (C-5) from the side chain of itaconate to a position between C-2 and C-3 in an, as yet, unknown straight chain intermediate prior to its conversion to succinate.
A distributed real-time operating system (1992)

Two versions of the HARTS operating system, which is based on Software Components Group's pSOS uniprocessor kernel, are presented. In one version, pSOS services are enhanced to provide interprocessor communication and a distributed naming service. In the second version, real-time fault-tolerant communication, including reliable broadcasting, clock synchronization, and group communication are added to the HARTS operating system. Three tools to evaluate the performance and fault tolerance dependability of HARTS hardware and software-a synthetic-workload generator, a monitor, and a fault injector-are described. The generator produces a synthetic workload, the monitor collects the performance data, and the fault injector simulates faulty behavior for further study. Together these tools create a facility that lets the user perform a wide range of experiments. The tools are independent, so they are equally effective separately or together, depending on the requirements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Epidermodysplasia Verruciformis as a Model of Human Papillomavirus—Induced Genetic Cancer of the Skin (1995)

Epidermodysplasia verruciformis is a model not only of cutaneous viral oncogenesis but also of local defense mechanisms in the progression of human papillomavirus-associated cancers.
Properties and applications of supercapacitors From the state-of-the-art to future trends (2000)

Electrochemical double-layer capacitors, also known as supercapacitors or ultracapacitors, are electrical storage devices, which have a relatively high energy storage density simultaneously with a high power density. Recent developments in basic technology, materials and manufacturability have made supercapacitors an imperative tool for shortterm energy storage in power electronics. With much higher energy density than today's capacitors and none of the problems associated with conventional battery technology, supercapacitors give an access to new power electronic and industrial storage applications.
Intelligent PLL Using Digital Processing for Network Synchronization (1983)

By combining the advanced technologies of a crystal oscillator, LSI, and a computer, an intelligent phase-locked loop (PLL) which uses digital processing (DP) can be created. This kind of PLL, which is referred to here as DP-PLL, includes a microprocessor and a digitally controlled crystal oscillator. It features excellent performance and countermeasures for disturbances of the input signal by stored program control. In this paper, implementation and performance of the DP-PLL are presented with the aim of application in a master-slave network synchronization system.
Evaluating the number of active flows in a scheduler realizing fair statistical bandwidth sharing (2005)

Despite its well-known advantages, per-flow fair queueing has not been deployed in the Internet mainly because of the common belief that such scheduling is not scalable. The objective of the present paper is to demonstrate using trace simulations and analytical evaluations that this belief is misguided. We show that although the number of flows in progress increases with link speed, the number that needs scheduling at any moment is largely independent of this rate. The number of such active flows is a random process typically measured in hundreds even though there may be tens of thousands of flows in progress. The simulations are performed using traces from commercial and research networks with quite different traffic characteristics. Analysis is based on models for balanced fair statistical bandwidth sharing and applies properties of queue busy periods to explain the observed behaviour.
A multidisciplinary study of psychogeriatric patients (1968)

ANDERSON, CATHERINE J.; A, PORRATA; E, LORE; R, ALEXANDER; R, MERCER; Blnisdell, F. Author Information
Mastery learning of elementary mathematics: Theory and data (1996)

In this final paper, which is the only one in this volume that has not been previously published, we develop in some detail a portion of the extensive work we have done together over nearly twenty years on the application of probabilistic models and methods to problems of curriculum and learning in a computer-based setting. It might seem that there is little connection between this work and what has been described in earlier parts of this volume. In our own mind, however, there is an intimate connection and considerable continuity. The general reason is easy to state. Although much of our work has been motivated by Bayesian considerations and the admiration we have for the pioneering work of Bruno de Finetti in developing concepts of subjective probability, we also recognize how complicated real applications of Bayesian ideas are. Even more generally, we recognize how complicated real applications of normative ideas are. The normative considerations that guide the work described here concern how to optimize the course of learning for each individual student. We pick as our example elementary mathematics, partly because there has been such a long history of research on the learning of elementary mathematics, especially arithmetic, throughout this century, beginning at least with the early work of Edward Thorndike, if not even earlier.
Instability of side-chain protecting groups during MALDI-TOF mass spectrometry of peptide fragments. (1996)

Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS), a well-suited method for the characterization of peptides and proteins, was used for analysis of protected peptide fragments. It is shown that acidic matrices, e.g. 2,5-dihydroxybenzoic acid, frequently used in MALDI-TOF MS of peptides, causes partial cleavage of acid-labile side-chain protecting groups. Because this effect is strongly related to the matrix used, the observed deprotection can be avoided by choosing an appropriate matrix such as 2,4,6-trihydroxyacetophenone or 2-amino-5-nitropyridine. The advantage of neutral matrix compounds for MALDI-TOF analysis of protected peptides is clearly demonstrated, confirming the potential of MALDI-TOF mass spectrometry.
IN-LINE FIBER EVANESCENT FIELD ELECTROOPTIC MODULATORS (2000)

Electrooptic modulators that consist of an optical fiber waveguide coupled to an electrooptic waveguide are reviewed. Desirable attributes of these devices are that the optical fiber is uninterrupted and the interaction with the electrooptic region occurs only where the optical properties are modulated. In this paper we review in-line fiber evanescent field modulators that we have implemented with electrooptic polymers and compound semiconductor quantum wells. We show that the beam propagation method can accurately simulate the behavior measured in these devices.
Characterization and expression pattern of the novel MIA homolog TANGO (2004)

A novel human gene, TANGO, encoding a MIA ('melanoma inhibitory activity') homologous protein was identified by a gene bank search. TANGO, together with the homologous genes MIA, OTOR (FPD, MIAL) and MIA2 define a novel gene family sharing important structural features, significant homology at both the nucleotide and protein level, and similar genomic organization. The four members share 34-45% amino acid identity and 47-59% cDNA sequence identity. TANGO encodes a mature protein of 103 amino acids in addition to a hydrophobic secretory signal sequence. Sequence homology confirms the highly conserved SH3 structure present also in MIA, OTOR and MIA2. Thus, it appears that there are a number of extracellular proteins with SH3-fold like structures. Interestingly, in situ hybridization, RT-PCR and Northern Blots revealed very broad TANGO expression patterns in contrast to the highly restricted expression patterns previously determined for the other members of the MIA gene family. The only cells lacking TANGO expression are cells belonging to the hematopoetic system. High levels of TANGO expression were observed both during embryogenesis and in adult tissues.
Preparation of chiral compounds with high optical purity by irradiation with circularly polarized light, a model reaction for the prebiotic generation of optical activity (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of chiral compounds with high optical purity by irradiation with circularly polarized light, a model reaction for the prebiotic generation of optical activityG. Balavoine, A. Moradpour, and H. B. KaganCite this: J. Am. Chem. Soc. 1974, 96, 16, 5152–5158Publication Date (Print):August 1, 1974Publication History Published online1 May 2002Published inissue 1 August 1974https://pubs.acs.org/doi/10.1021/ja00823a023https://doi.org/10.1021/ja00823a023research-articleACS PublicationsRequest reuse permissionsArticle Views1795Altmetric-Citations228LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Assessment of Unglazed Solar Domestic Water Heaters (2005)

Conference paper investigating cost-performance tradeoffs in replacing glazed collectors with unglazed collectors in solar domestic water heating systems.
Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer (2010)

Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. Here, we report that periostin, a highly expressed cell adhesion molecule, is a key component of a novel tumor-invasive signature obtained from an organotypic culture model of engineered ESCC. This tumor-invasive signature classifies with human ESCC microarrays, underscoring its utility in human cancer. Genetic modulation of periostin promotes tumor cell migration and invasion as revealed in gain-of-loss and loss-of-function experiments. Inhibition of epidermal growth factor receptor signaling and restoration of wild-type p53 function were each found to attenuate periostin, suggesting the interdependence of two common genetic alterations with periostin function. Collectively, our studies reveal periostin as an important mediator of ESCC tumor invasion and they indicate that organotypic (three-dimensional) culture can offer an important tool to discover novel biological effectors in cancer.