gebhart/patrepeval huggingface dataset:
Covering Pareto-optimal fronts by subswarms in multi-objective particle swarm optimization (2005)

Covering the whole set of Pareto-optimal solutions is a desired task of multiobjective optimization methods. Because in general it is not possible to determine this set, a restricted amount of solutions are typically delivered in the output to decision makers. We propose a method using multiobjective particle swarm optimization to cover the Pareto-optimal front. The method works in two phases. In phase 1 the goal is to obtain a good approximation of the Pareto-front. In a second run subswarms are generated to cover the Pareto-front. The method is evaluated using different test functions and compared with an existing covering method using a real world example in antenna design.
A new 6-DOF parallel robot with simple kinematic model (2014)

This paper presents a novel six-legged parallel robot, the kinematic model of which is simpler than that of the simplest six-axis serial robot. The new robot is the 6-DOF extension of the Cartesian parallel robot. It consists of three pairs of base-mounted prismatic actuators, the directions in each pair parallel to one of the axes of a Cartesian coordinate system. In each of the six legs, there are also two passive revolute joints, the axes of which are parallel to the direction of the prismatic joint. Finally, each leg is attached to the mobile platform via a spherical joint. The direct kinematics of the novel parallel robot can be solved easily by partitioning the orientation and the position of the mobile platform. There are eight distinct solutions, which can be found directly by solving a linear system and alternating the signs of three radicals. This parallel robot has a large workspace and is suitable for machining or rapid prototyping, as detailed in this paper.
Syntheses, Structures, and Sensitized Lanthanide Luminescence by Pt → Ln (Ln = Eu, Nd, Yb) Energy Transfer for Heteronuclear PtLn<sub>2</sub> and Pt<sub>2</sub>Ln<sub>4</sub> Complexes with a Terpyridyl-Functionalized Alkynyl Ligand (2007)

Reaction of Pt(dppm-P,P')Cl2 (dppm = 1,2-bis(diphenylphosphino)methane) with HCCPhtpy (HCCPhtpy = 4'-(4-ethynylphenyl)-2,2':6',2"-terpyridine) in the presence of copper(I) iodide and diisopropylamine induced isolation of mononuclear complex cis-Pt(dppm-P,P')(C[triple bond]CPhtpy)2 (1), which can be converted into face-to-face diplatinum(II) species Pt2(mu-dppm)2(C[triple bond]CPhtpy)4 (5) when equivalent dppm is added. Incorporating 1 or 5 to Ln(hfac)3(H2O)2 (Hhfac = hexafluoroacetylacetone) gave PtLn2 (Ln = Nd (2), Eu (3), Yb (4)) or Pt2Ln4 (Ln = Nd (6), Eu (7), Gd (8), Yb (9)) adducts with the lanthanide centers chelated by terdentate terpyridyl in the bridging C[triple bond]CPhtpy. The structures of 1, 6, 7, and 9 were determined by X-ray crystallography. Upon excitation at lambdaex = 360-450 nm (2-4) or 360-500 nm (6-9), where the PtII alkynyl antenna chromophores absorb strongly but the model complexes Ln(hfac)3(HC[triple bond]CPhtpy) lack obvious absorption in this region, these PtLn2 and Pt2Ln4 (Ln = Nd, Eu, Yb) species exhibit band-like lanthanide luminescence that is typical of the corresponding Ln3+ ions, demonstrating unambiguously that efficient Pt --> Ln energy transfer occurs indeed from the PtII alkynyl antenna chromophores to the lanthanide centers across the bridging CCPhtpy with intramolecular Pt...Ln distances being ca. 14.2 A. The Pt --> Ln energy transfer rate (kET) is 6.07 x 10(7) s(-1) for Pt2Nd4 (6) and 2.12 x 10(5) s(-1) for Pt2Yb4 (9) species.
Comparison of fluorescence-based temperature sensor schemes: Theoretical analysis and experimental validation (1998)

The performance of the two most promising fluorescence-based temperature sensing techniques, namely the fluorescence intensity ratio (FIR) and fluorescence lifetime (FL) schemes, have been compared. Theoretical calibration graphs for the two methods illustrate the useful monotonic change of the response with temperature variation. Comparison of the responses and the sensitivities of the two schemes show that at very low temperatures the FIR method exhibits a significant variation with temperature, while the response of the FL method becomes constant with its sensitivity approaching zero. With increasing temperature, the FIR and the FL methods (with short relaxation times and shorter intrinsic lifetimes of the upper energy levels) share a similar sensitivity over a wide temperature range. The presence of a long relaxation time or a longer intrinsic lifetime of the upper level in the use of the FL method gives a less satisfactory response. Experimental data obtained for a range of dopant ions in various host materials are found to be consistent with the theoretical expectation, with each material having a specific energy gap difference. The sensitivities of each material are compared graphically which would allow the most appropriate sensor for an intended application to be selected.
Dietary supplementation with taurine and niacin prevents the increase in lung collagen cross‐links in the multidose bleomycin hamster model of pulmonary fibrosis (1994)

Taurine and niacin have been previously found to block the accumulation of collagen in lung in the multidose bleomycin hamster model of pulmonary fibrosis. Previous studies have found an increase in the pulmonary collagen cross-links dihydroxylysinonoroleucine (DHLNL) and hydroxypyridinium (OHP) in the single dose bleomycin rat model. In this study, we asked if taurine and niacin would block the increase in DHLNL and OHP in the multidose bleomycin hamster model of lung fibrosis. Hamsters were intratracheally instilled with three consecutive doses of saline or bleomycin sulfate 1 week apart (2.5, 2.0, 1.5 units/5 mL/kg). Animals were fed diet containing either 2.5% niacin and 2.5% taurine or control diet throughout the experiment. The four groups were saline-instilled with control diet (SCD), bleomycin instilled with control diet (BCD), bleomycin-instilled with taurine-niacin in diet (BTN), and saline-instilled with taurine-niacin in diet (STN). Animals were sacrificed at 1, 4, and 8 weeks after the last bleomycin instillation. Hydroxyproline per lung in the BCD group was significantly elevated by 38, 56, and 60% over the SCD group at 1, 4, and 8 weeks, respectively. There were no statistically significant differences among the four groups in DHLNL (mmole) per mole collagen at the 1 or 8 week time point. At four weeks, DHLNL was significantly elevated by 46.4% in the BCD group over the SCD group. The OHP (mmole) per mole of collagen at 1 and 4 weeks in the BCD group was not statistically different from the SCD group.(ABSTRACT TRUNCATED AT 250 WORDS)
Scene Reconstruction from Community Photo Collections (2010)

The literally billions of images available from online photo-sharing sites offer an I unprecedented wealth of information but also add additional layers of complexity for reconstruction applications.
Drug-Drug Interactions with Glucagon-Like Peptide-1 Receptor Agonists (2012)

GLP-1RAs may produce clinically significant interactions with drugs that require achievement of target peak concentrations or a rapid onset of action. Studies in patients with type 2 diabetes are needed to further assess and allow comparison of several GLP-1RA agents' impact on steady-state pharmacokinetics and pharmacodynamics of concomitant oral medications.
Design and Preliminary Implementation of an N $\times$ N Diffractive All-Optical Fiber Optic Switch (2013)

We have demonstrated a diffraction-based nonblocking, scalable N × N optical switch employing a digital micromirror display (DMD) with 12 μs switching speed, performing 100 times faster than the currently available technology. The distributed nature of diffraction makes this switch more robust than one-to-one reflective systems where a single mirror failure incapacitates an entire connection. We thereby address a key bottleneck in data centers and optical aggregation networks by decreasing circuit-switching speed and allowing for facile port count scalability.
Two different genes from <i>Schwanniomyces occidentalis</i> determine ribosomal resistance to cycloheximide (1993)

Two genes (SCR1 and SCR2) encoding natural cycloheximide resistance in the budding yeast Schwanniomyces occidentalis have been cloned by expression in Saccharomyces cerevisiae. Both genes determine resistance to the inhibitory action of cycloheximide on the ribosome, SCR1 and SCR2 are present as single copies in Schwanniomyces occidentalis, where they map on chromosomes II and V, respectively. The nucleotide sequence of SCR2 contains an open reading frame of 321 nucleotides which is interrupted by an intron of 452 nucleotides. It encodes a polypeptide of 106 amino acids of molecular mass 12.25 kDa and pI 11.19. The deduced amino acid sequence shows a high degree of similarity to the L41 protein of the 60S ribosomal subunit from several eukaryotic organisms. The intron and the 5' non-coding region of SCR2 possess conserved elements which are typical of yeast ribosomal protein genes. A single amino acid change determines the resistance or sensitive phenotype to cycloheximide of the 80S ribosome since replacement of Gln56 in L41 from Schwanniomyces with Pro, by site-directed mutagenesis, confers cycloheximide sensitivity. SCR2 may serve as a practical yeast cloning marker if integrated in a multicopy plasmid.
CloudClustering: Toward an Iterative Data Processing Pattern on the Cloud (2011)

As the emergence of cloud computing brings the potential for large-scale data analysis to a broader community, architectural patterns for data analysis on the cloud, especially those addressing iterative algorithms, are increasingly useful. MapReduce suffers performance limitations for this purpose as it is not inherently designed for iterative algorithms. In this paper we describe our implementation of Cloud Clustering, a distributed k-means clustering algorithm on Microsoft's Windows Azure cloud. The k-means algorithm makes a good case study because its characteristics are representative of many iterative data analysis algorithms. Cloud Clustering adopts a novel architecture to improve performance without sacrificing fault tolerance. To achieve this goal, we introduce a distributed fault tolerance mechanism called the buddy system, and we make use of data affinity and check pointing. Our goal is to generalize this architecture into a pattern for large-scale iterative data analysis on the cloud.
Challenges of Deploying PKI based Client Digital Certification (2016)

We are confronted with the threat from the theft of user-id / password information caused by phishing attacks. Now authentication by using the user-id and password is no longer safe. We can use the PKI-based authentication as a safer authentication mechanism.
Ternary Matrix for the Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI–TOF MS) Analysis of Non-fuel Lipid Components in Biodiesel (2011)

Trace components present in biodiesel have been shown to contribute to the precipitation of solids at temperatures above the cloud point. These precipitates represent an operability problem for use of biodiesel in cold climates. Separation methods for analysis of trace lipid impurities, such as gas and liquid chromatography, have been problematic, and chromatographic signals for these compounds are often eclipsed by the signals for the fatty acid methyl esters (FAMEs), the major components of biodiesel. The method described herein has been developed as a rapid procedure for analyzing non-FAME lipid biodiesel components, which have been postulated to contribute to cold-weather operability problems. Representative standards of the non-FAME lipids present in biodiesel were analyzed with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI–TOF MS) using pure and mixed matrix systems. An optimized ternary matrix system consisting of dithranol, 2,5-dihydroxybenzoic acid, and α-cyano-4-hydroxycinnamic acid doped with sodium iodide was developed for analysis of the widest range of trace components possible by capitalizing on the positives of each matrix in ionizing compounds with differing functional groups. Mixtures of matrix compounds produced smaller, more homogeneous crystals, which resulted in increased reproducibility and sensitivity. This increase in reproducibility allowed quantitative relationships to be established with standards and between fuel samples. Spectral peak identification was based on molecular weight and tandem mass spectrometry collision-induced dissociation. Two palm oil-derived biodiesels, one of which was distilled, were analyzed to determine their non-FAME components and to quantitatively compare the number and relative concentration of trace species detected. Trace lipid species in precipitates from canola-oil-derived biodiesel were also isolated via refrigerated centrifugation, followed by analysis with the ternary matrix.
MEMS Display: Emerging Technology for Next Generation Avionics Display (2012)

Avionics display systems using CRTs as core of the \nprojection system suffer from reliability issues added to \nincreased weight and cost of the associated circuitry. Though CRTs offer some advantages in the form of good brightness and contrast ratio even in the high ambient light conditions, recent advancement in micro electomechanical system (MEMS) based display technology ushered in an era of miniature displays having low power consumption and better reliability. Digital Micromirror Device (DMD) array from Texas Instruments and Laser Scanning Displays (LSD) have shown enormous potential to be the suitable replacement to the CRTs in air-borne applications. Head up Displays (HUD) using DMD micromirror array and a novel Head Mounted Display (HMD) technology known as the Retinal Scanning Display (RSD) using LSDs are being tested and further improved to meet the military standards.
Attenuated Host Resistance against<i>Mycobacterium bovis</i>BCG Infection in Mice Lacking Osteopontin (1999)

Expression of the cytokine osteopontin (OPN) is elevated in granulomas caused by Mycobacterium tuberculosis. We tested the hypothesis that OPN contributes to host protection in a mouse model of mycobacterial infection. When infected with Mycobacterium bovis BCG, mice lacking a functional OPN gene had more severe infections characterized by heavier bacterial loads and a delayed clearance of the bacteria. The OPN-null mice had greater granuloma burdens consistent with the elevated bacterial load. The ability of osteopontin to facilitate the clearance of mycobacteria was most pronounced early after infection and appeared to be independent of known mediators of resistance to infection by mycobacteria: antigen-specific T-cell immunity, gamma interferon production, and nitric oxide production. BCG grew more rapidly in macrophages derived from OPN-null mice than in those from wild-type mice, demonstrating that the null phenotype was due to an intrinsic macrophage defect. These results indicate that osteopontin augments the host response against a mycobacterial infection and that it acts independently from other antimycobacterial resistance mechanisms.
Capture and electrochemical conversion of CO<sub>2</sub>to ultrathin graphite sheets in CaCl<sub>2</sub>-based melts (2015)

A novel method for capture and electrochemical conversion of CO<sub>2</sub>to graphite sheets in molten CaCl<sub>2</sub>with the utilization of renewable energy sources has been proposed. The reduction mechanism was investigated and the results indicate that two steps are involved.
Efficacy of a prebrushing rinse in reducing dental plaque. (1990)

A double-blind parallel design controlled clinical trial was conducted to determine the effect of rinsing with Plax prebrushing rinse on supragingival plaque when used alone and when used just after toothbrushing. One hundred-three (103) subjects refrained from oral hygiene measures for 24 hours. Following a baseline plaque examination, subjects were randomly assigned to either a Plax or to a placebo group, rinsed with 15 ml of their respective rinse for 30 seconds, and were rescored for plaque (postrinse evaluation). Subjects then rinsed again with their assigned rinse, brushed immediately with water for 15 seconds, and were rescored for plaque (postbrush evaluation). Rinsing alone reduced plaque from baseline by 9.0% for Plax and by 10.7% for control. Plax and the control rinse followed by brushing both significantly reduced plaque area scores from baseline by 39.6% and 36.3%, respectively. There were no significant differences between Plax and control mouthrinse in reducing plaque area scores, whether used alone (postrinse) or used just prior to brushing for 15 seconds with water (postbrush evaluation). Use of Plax therefore did not increase the plaque removing efficacy of toothbrushing.
Structural Determinants of Opioid Activity in the Orvinols and Related Structures:  Ethers of Orvinol and Isoorvinol (2000)

A series of ethers of orvinol and isoorvinol has been prepared and evaluated in opioid receptor binding and in vitro functional assays. The most striking finding was the very large difference in kappa-opioid receptor activity between the diastereomeric ethyl ethers: 46-fold in binding, 150-fold in GPI, and 900-fold in the [(35)S]GTPgammaS assay in favor of the (R)-diastereomer. Additionally in the (R)-series there was a 700-fold increase in kappa-agonist potency in the [(35)S]GTPgammaS assay when OEt was replaced by OBn. The data can be explained in a triple binding site model: an H-bonding site, a lipophilic site, and an inhibitory site with which the 20-Me group in the (S)-ethers may interact. It appears that kappa-agonist binding of the orvinols avoids the inhibitory site in the intramolecular H-bonded conformation.
Palladium-catalyzed chemistry of .beta.-lactam vinyl triflates: coupling with organostannanes and alkoxycarbonylation (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticlePalladium-catalyzed chemistry of .beta.-lactam vinyl triflates: coupling with organostannanes and alkoxycarbonylationGwendolyn K. Cook, William J. Hornback, Chris L. Jordan, John H. McDonald III, and John E. MunroeCite this: J. Org. Chem. 1989, 54, 24, 5828–5830Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/jo00285a037https://doi.org/10.1021/jo00285a037research-articleACS PublicationsRequest reuse permissionsArticle Views450Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
In Situ Synthesis of Efficient Water Oxidation Catalysts in Laser-Induced Graphene (2018)

NiFe-based catalysts are highly active for the oxygen evolution reaction (OER) in alkaline electrolytes. These catalysts are generally synthesized by solution-based methods. We present an in situ synthesis method for NiFe-based OER catalysts through a laser-induced graphene (LIG)-assisted process. By loading the metal precursor on a preformed LIG surface followed by laser scribing, we synthesized the NiFe/LIG catalysts via a solid phase transition that did not require utilization of CVD or typical solution-based reactions. The catalysts showed high OER activity and durability. The overpotential at 10 mA cm–2 is as low as 240 mV with a Tafel slope of 32.8 mV dec–1 in 1 M KOH. Additionally, this method worked well on a carbon fiber paper substrate, providing a convenient approach for the preparation of a free-standing catalytic electrode. This method provides a potential route to the facile synthesis of a variety of catalysts on a conductive surface.
A Comparison of Type I Collagen, Fibronectin, and Vitronectin in Supporting Adhesion of Mechanically Strained Osteoblasts (2002)

We used an adhesion assay for cells cultured under high dynamic strain to measure human osteoblast-like HOS cell adherence to immobilized type I collagen, fibronectin, and vitronectin. These conditions were designed to model the increased forces present at unstable fractures or loose joint prostheses. At a constant, low protein-coating density (1000 molecules/microm2) and 20% cyclic strain for 24 h, type I collagen, fibronectin, and vitronectin supported 24.6 +/- 2%, 16.7 +/- 3%, and 1.1 +/- 1% adherence, respectively, which paralleled the relative number of integrin-binding sites in each protein. Thus, when the number of available binding sites was limited, strain resistance was proportional to the number of integrin-ligand interactions. In contrast, at high protein-coating densities (> or = 2,500 molecules/microm2), vitronectin supported greater adherence (45.7 +/- 2%) when compared with type I collagen (37 +/- 2%) or fibronectin (34.8 +/- 2%) and directed constitutive expression of osteopontin (OPN), which suggested that there exist discrete signals on vitronectin receptor occupancy that promoted cell adherence and survival under strain. Integrin-mediated binding was necessary for resistance to strain, as evidenced by the low levels of strain resistance observed when cells were adherent in a nonintegrin-dependent manner. These findings support the utilization of at least two distinct mechanisms (i.e., tensegrity and integrin-mediated signal transduction) by HOS cells to remain adherent and viable on exposure to mechanical forces.
Partial purification and reconstitution of the sarcolemmal <scp>l</scp>-lactate carrier from rat skeletal muscle (1994)

Purified sarcolemmal membranes from mixed rat hindlimb muscle were solubilized with octylglucoside and the extract subjected to hydroxylapatite (HA) chromatography. Following protein elution with a sodium phosphate gradient and detergent removal by dialysis, the HA eluate was reconstituted into asolectin liposomes using a freeze-thaw procedure. Specific L-[14C]lactate transport activity eluting from the 0.2 M sodium phosphate fraction was 30-fold higher compared with native sarcolemmal vesicles (31.64 versus 1.06 nmol/min per mg). The reconstituted carrier exhibited Michaelis-Menten saturation kinetics with Km and Vmax. values of 46.2 +/- 6.6 mM and 498.7 +/- 17.2 nmol/15 s per mg respectively. L-Lactate transport activity was inhibited 57% by preincubation of proteoliposomes with 10 mM alpha-cyano-4-hydroxycinnamate, a known inhibitor of lactate transport. Analysis of the HA eluates by SDS/PAGE showed the presence of a 34 kDa band corresponding to lactate transport activity. Reconstitution of lactate transport activity eluting from the HA column, together with SDS/PAGE analysis suggests the presence of a 34 kDa polypeptide mediating sarcolemmal lactate exchange in rat skeletal muscle.
Atrial autonomic innervation remodelling and atrial fibrillation inducibility after epicardial ganglionic plexi ablation (2010)

Atrial autonomic innervations remodelling may be the mechanism of induced AF after GP ablation.