gebhart/patrepeval huggingface dataset:
Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1) (1997)

We report identification of a new human nucleoside transporter protein by molecular cloning and functional expression of its cDNA. Previously, we used expression selection in Xenopus oocytes to isolate a cDNA from rat jejunal epithelium encoding the pyrimidine-selective Na+-dependent nucleoside transporter rCNT1 (Q.-Q. Huang, S. Y. M. Yao, M. W. L. Ritzel, A. R. P. Paterson, C. E. Cass, and J. D. Young. J. Biol. Chem. 269: 17757-17760, 1994). cDNAs for a human homologue of rCNT1, designated hCNT1, have been isolated from human kidney by hybridization cloning and reverse transcriptase polymerase chain reaction amplification strategies. hCNT1 was 83% identical to rCNT1 in amino acid sequence and exhibited the transport characteristics of an Na+-dependent nucleoside transporter with selectivity for pyrimidine nucleosides and adenosine when expressed in Xenopus oocytes. Deoxyadenosine, which undergoes net renal secretion, and guanosine were poor permeants. hCNT1 did, however, transport 3'-azido-3'-deoxythymidine. This is the first demonstration that members of the CNT family exist in human cells and provides evidence of their involvement in the renal transport of physiological nucleosides and nucleoside drugs. The hCNT1 gene was mapped to chromosome 15q25-26.
Analysis of Escherichia coli RNase E and RNase III activity in vivo using tiling microarrays (2010)

Tiling microarrays have proven to be a valuable tool for gaining insights into the transcriptomes of microbial organisms grown under various nutritional or stress conditions. Here, we describe the use of such an array, constructed at the level of 20 nt resolution for the Escherichia coli MG1655 genome, to observe genome-wide changes in the steady-state RNA levels in mutants defective in either RNase E or RNase III. The array data were validated by comparison to previously published results for a variety of specific transcripts as well as independent northern analysis of additional mRNAs and sRNAs. In the absence of RNase E, 60% of the annotated coding sequences showed either increases or decreases in their steady-state levels. In contrast, only 12% of the coding sequences were affected in the absence of RNase III. Unexpectedly, many coding sequences showed decreased abundance in the RNase E mutant, while more than half of the annotated sRNAs showed changes in abundance. Furthermore, the steady-state levels of many transcripts showed overlapping effects of both ribonucleases. Data are also presented demonstrating how the arrays were used to identify potential new genes, RNase III cleavage sites and the direct or indirect control of specific biological pathways.
Retraction: Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors (2008)

BioMed Central is publishing a retraction of this article [1] as the article was published in error. BioMed Central apologize to the authors for the error and any inconvenience caused. An apology is also extended to the readers.
Steganographic fiber-optic transmission using coherent spectral-phase-encoded optical CDMA (2008)

Stealth communication using coherent SPE-OCDMA is demonstrated. The coherent approach can provide higher spectral efficiency than incoherent optical CDMA.
Synthesis of some pterocarpenes obtained from Brya ebenus (1982)

The syntheses of bryacarpenes-1, -2, and -4, [4,10-dihydroxy-3,8,9-trimethoxy-(1), 10-hydroxy-3,8,9-trimethoxy-(2), and 4-hydroxy-3,9,10-trimethoxy-6H-benzofuro[3,2-c][1]benzopyran (3)], (±)-bryaflavan [(±)-3′,6,7-trihydroxy-2′,4′-dimethoxyisoflavan (33)], 4-hydroxy-3,7-dimethoxy-(18) and 3,7-dimethoxy-6H-benzofuro[3,2-c][1]benzopyran-9,10-quinone (19) is described. The quinones are not identical with bryaquinone and deoxybryaquinone, for which structures (18) and (19) had been proposed previously. In the syntheses of the pterocarpenes the novel reduction of isoflavones to isoflavan-4-ones by di-isobutylaluminium hydride was used.
High-level synthesis under multi-cycle interconnect delay (2001)

As process technology goes into deep submicron range, interconnect delay becomes dominant among overall system delay, occupying most of the system clock cycle time. Interconnect delay is now a crucial factor that needs to be considered even during high-level synthesis. In this paper, we propose a concurrent scheduling and binding algorithm that takes interconnect delay into account. We first define our distributed target architecture, which minimizes the effect of interconnect delay on clock cycle time. We no longer assume that interconnect delay between functional units is a part of one clock cycle. Interconnect delay can span over multiple clock cycles. We incorporate the concept of multi-cycle interconnect delay into scheduling and binding process, to reduce the critical path length and therefore the system latency. We show that by introducing interconnect delay, we can obtain latency improvement of up to 54 % and of 37% on the average.
High-Voltage Spark Spectra: Utility as a Function of Temporal and Spatial Resolution (1987)

The utility of the high-voltage spark discharge as an analytical emission source is considered. Temporal and spatial windowing was used to reiterate well-documented characteristics of heterogeneities of the spark plasma in both time and space. Cathodes of pure magnesium and aluminum 2024 alloy were used as samples. It was shown that by using a unidirectional current waveform, and by selecting a spatial position off of the interelectrode axis, at times late in the plasma lifetime, one can obtain relatively clean emission spectra (high signal-to-background ratio). This is in contrast to recent literature reports which suggest that the high-voltage spark exclusively produces spectra which are complex and which demonstrate poor background characteristics. The dynamic range of the spark is also demonstrated to be somewhat larger than the cited work suggests. The implications of various methods of presenting experimental results for such data are discussed.
<title>Extracting the scattering coefficient of sea water from the return time signal of ocean lidar</title> (1993)

An Ocean Lidar system was developed for measuring the optical parameters of the sea water. In our system, the FOV of the receive is changed to obtain the different sea water optical parameters. The attenuation coefficient c equals 0.32 m-1, absorption a equals 0.07 m-1 with Sechhi Disc Depth (SDD) 13 m and c equals 0.31 m-1, a equals 0.06 m-1 with SDD equals 14 m are obtained in situ separately.
Visual Analysis of Movement Behavior Using Web Data for Context Enrichment (2014)

With increasing use of GPS devices more and more location-based information is accessible. Thus not only more movements of people are tracked but also POI (point of interest) information becomes available in increasing geo-spatial density. To enable analysis of movement behavior, we present an approach to enrich trajectory data with semantic POI information and show how additional insights can be gained. Using a density-based clustering technique we extract 1.215 frequent destinations of ~150.000 user movements from a large e-mobility database. We query available context information from Foursquare, a popular location-based social network, to enrich the destinations with semantic background. As GPS measurements can be noisy, often more then one possible destination is found and movement patterns vary over time. Therefore we present highly interactive visualizations that enable an analyst to cope with the inherent geospatial and behavioral uncertainties.
Radicicol-sensitive Peptide Binding to the N-terminal Portion of GRP94 (2002)

GRP94 is a molecular chaperone that carries immunologically relevant peptides from cell to cell, transferring them to major histocompatibility proteins for presentation to T cells. Here we examine the binding of several peptides to recombinant GRP94 and study the regulation and site of peptide binding. We show that GRP94 contains a peptide-binding site in its N-terminal 355 amino acids. A number of peptides bind to this site with low on- and off-rates and with specificity that is distinct from that of another endoplasmic reticulum chaperone, BiP/GRP78. Binding to the N-terminal fragment is sufficient to account for the peptide binding activity of the entire molecule. Peptide binding is inhibited by radicicol, a known inhibitor of the chaperone activities of HSP90-family proteins. However, the peptide-binding site is distinct from the radicicol-binding pocket, because both can bind to the N-terminal fragment simultaneously. Furthermore, peptide binding does not cause the same conformational change as does binding of radicicol. When the latter binds to the N-terminal domain, it induces a conformational change in the downstream, acidic domain of GRP94, as measured by altered gel mobility and loss of an antibody epitope. These results relate the peptide-binding activity of GRP94 to its other function as a chaperone.
Noncovalent Functionalization of Multiwalled Carbon Nanotubes:  Application in Hybrid Nanostructures (2006)

We developed a reproducible, noncovalent strategy to functionalize multiwalled carbon nanotubes (MWNTs) via embedding nanotubes in polysiloxane shells. (3-Aminopropyl)triethoxysilane molecules adsorbed to the nanotube surfaces via hydrophobic interactions are polymerized simply by acid catalysis and form a thin polysiloxane layer. On the basis of the embedded MWNTs, negatively charged gold nanoparticles are anchored to the nanotube surfaces via electrostatic interactions between the protonated amino groups and the gold nanoparticles. Furthermore, these gold nanoparticles can further grow and magnify along the nanotubes through heating in HAuCl4 aqueous solution at 100 degrees C; as a result these nanoparticles are joined to form continuous gold nanowires with MWNTs acting as templates.
Better local government: Implications for recreation and sport in New Zealand (2012)

The Government has released a document titled Better Local Government outlining an eight-point reform programme. The purpose of this paper is to discuss the implications that these proposals may have on local governments' role in the provision of sport and recreation.
Towards a modularized semantic web (2002)

Modularization is an established principle in software engineering. It has also been considered as a core principle when developing the World Wide Web. Along the same lines, the Semantic Web has to be based on modularization principles. This paper provides a first step into a modularized Semantic Web. It provides an elaborated and carefully evaluated view on existing technologies for naming, referring and modularization in the Web. Based on this analysis we propose means to import and include (parts) of RDF models by extending the RDF(S) meta-model, introducing new primitives for modularity. 1.
Peer Coaching for Better Teaching (1996)

A recent article in the New York Times announced: Cornell to Evaluate Teaching Ability in Tenure Decisions. It is an account of Cornell's efforts to place more emphasis on teaching by establishing rigorous stan dards for evaluation to be used by tenure and promotion committees (DePalma 1992). The remarkable aspect of this arti cle is not the exemplary system that Cor nell proposes to implement, but the fact that a major university deciding to focus on the improvement of teaching made headlines in an influential newspaper. Fueled by public and media perception that many institutions overemphasize research at the expense of excellence in teaching, colleges and universities are revisiting their priorities, with particular stress on evaluating and improving teach ing. The University of New Hampshire's doctoral program in psychology, for exam ple, now includes a learning-to-teach com ponent in addition to a strong focus on research skills (Fernald 1995). The growth in programs that provide for peer review of teaching is further evidence of the new focus. The 1991 Phister Report at the Uni versity of California, for example, recom mended that teaching be peer reviewed
Inhibition of monoacylglycerol lipase terminates diazepam‐resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet (2017)

MAGL represents a novel therapeutic target for treating status epilepticus and improving its sequelae. CPD-4645 therapeutic effects appear to be predominantly mediated by modulation of neuroinflammation.
Turn-Intent Analysis Using Body Pose for Intelligent Driver Assistance (2006)

Pervasive computing technologies hold much promise for enhancing automotive safety by introducing a new range of human-centered driver assistance systems. Requirements for designing an active safety system are accurately, reliably, and quickly identifying the conditions leading to an accident and inducing corrective actions to prevent the accident. The authors propose a driver turn-maneuver prediction system using a two-class pattern classification algorithm using driver-pose and steering-angle information. They analyze classifier-detection performance using receiver-operator-characteristic curves. These curves provide a picture of the attainable proactivity versus transparency ratios, pertaining to a pervasive computing system's ability to foresee the user's needs as compared to the system's ability not to annoy the user. The goal is to motivate the development of both vision-based body-pose recovery and behavior recognition algorithms for driver assistance systems. This article is part of a special issue on Intelligent Transportation.
Sound cancellation by the use of secondary multipoles (1995)

In this paper, global free-field cancellation in the region exterior to a single compact primary source is discussed. The nature of the secondary source or sources required to achieve such cancellation, either globally or in particular regions, is a subject of current interest. In particular, results are presented that relate to global cancellation of a primary monopole’s sound field by the use of a single, multipole secondary source. The secondary multipole component source strengths required to achieve global cancellation can be found in a number of ways. For example, they may be obtained directly from a multipole expansion of the primary monopole sound field, as originally suggested by Kempton. However, improved attenuation can be achieved by choosing the secondary multipole component source strengths to minimize the total sound power radiated by the combination of primary and secondary sources. Closed form solutions for secondary multipole component strengths have been derived for both the latter case and for Kempton’s approach and are presented here along with formulae for the corresponding reductions of sound power and sound pressure. It will also be shown that it is more efficient in some instances to use a secondary multipole than an array of secondary monopoles for global cancellation. However, the primary conclusion of the present work is that useful levels of global far-field cancellation may be obtained by using secondary sources of higher than monopole order placed at a relatively large fraction of a wavelength from the primary source.
A Preliminary Study Towards an Innovative Diesel HCCI Combustion (2007)

Homogeneous-charge, compression-ignition (HCCI) combustion is triggered by spontaneous ignition in diluted homogeneous mixtures and has a gradual trend thanks to suitable solutions. It is considered a very effective way to reduce engine pollutant emissions, however only experimental prototypes have been based on this concept, except for a few small two-stroke engines. HCCI combustion is feasible with fuels both for S.I. and for C.I. engines, but currently it does not cover the whole engine operating field, thus the engine must be built to operate also as a conventional engine. In order to obtain a gradual combustion and not a simultaneous reaction (as it would be in spontaneously ignited homogeneous mixture), lean mixture is used and appropriate solutions, as Exhaust Gas Recirculation (EGR), are necessary. However, the admission of exhaust gas into the cylinder goes to detriment of engine maximum mean effective pressure. This paper concerns a preliminary study of an innovative concept to control HCCI combustion in Diesel-fuelled engines, apart from exhaust gas presence, the function of which is limited to NOx emission control. The main purpose of the research is the obtaining of Diesel HCCI combustion also with high mean effective pressures rendering the combustion behaviour more controllable as well. The concept consists in forming a pre-compressed homogenous charge outside the cylinder and in gradually admitting it into the cylinder during the combustion process. In this way, combustion can be controlled by the flow rate transfer and high pressure gradients, typical of common HCCI combustion, can be limited as well. A first analysis has been done, considering a cylinder filled with a perfectly stirred mixture of air and diesel fuel through a transfer duct, only to test the validity of the concept, regardless of which effective solution will be adopted. Both Two and Four Stroke operations have been considered to realize the concept. Results in terms of pressure, heat release rate, temperature and emission production have pointed out the validity of the concept. Especially the Two Stroke solution produces more soot than the conventional Diesel, pointing out that the air-fuel mixing is probably not optimized. Regarding NOx emissions, both the proposed solutions give better results than the conventional Diesel engine.
Electrochemical Behaviour of Some Mechanically Alloyed Mg — Ni-Based Amorphous Hydrogen Storage Alloys* (1994)

Article Electrochemical Behaviour of Some Mechanically Alloyed Mg — Ni-Based Amorphous Hydrogen Storage Alloys* was published on January 1, 1994 in the journal Zeitschrift für Physikalische Chemie (volume 183, issue 1-2).
Quantum-dot vertical-cavity surface-emitting laser based on the Purcell effect (1999)

A quantum-dot vertical-cavity surface-emitting laser based on a modified Purcell effect is described. It is shown that the quantum-field confinement can greatly improve the modulation response, while arrays of such elements can generate power levels useful for high-speed data communication. The high-speed pulse response allows bias-free operation and makes the microcavity array an attractive replacement for single-aperture vertical-cavity surface-emitting lasers.
The Assembly and Remodeling of the Extracellular Matrix in the Growth Plate in Relationship to Mineral Deposition and Cellular Hypertrophy: An In Situ Study of Collagens II and IX and Proteoglycan (2002)

The recent development of new specific immunoassays has provided an opportunity to study the assembly and resorption of type II and IX collagens of the extracellular matrix in relationship to endochondral calcification in situ. Here, we describe how in the bovine fetal physis prehypertrophic chondrocytes deposit an extensive extracellular matrix that, initially, is rich in both type II and type IX collagens and proteoglycan (PG; principally, aggrecan). The majority of the alpha1(IX)-chains lack the NC4 domain consistent with our previous studies with cultured chondrocytes. During assembly, the molar ratio of type II/COL2 domain of the alpha1(IX)-chain varied from 8:1 to 25:1. An increase in the content of Ca2+ and inorganic phosphate (Pi) was initiated in the prehypertrophic zone when the NC4 domain was removed selectively from the alpha1(IX)-chain. This was followed by the progressive loss of the alpha1(IX) COL2 domain and type II collagen. In the hypertrophic zone, the Ca2+/Pi molar ratio ranged from 1.56 to a maximum of 1.74, closely corresponding to that of mature hydroxyapatite (1.67). The prehypertrophic zone had an average ratio Ca2+/Pi ranging from 0.25 to 1, suggesting a phase transformation. At hypertrophy, when mineral content was maximal, type II collagen was reduced maximally in content coincident with a peak of cleavage of this molecule by collagenase when matrix metalloproteinase 13 (MMP-13) expression was maximal. In contrast, PG (principally aggrecan) was retained when hydroxyapatite was formed consistent with the view that this PG does not inhibit and might promote calcification in vivo. Taken together with earlier studies, these findings show that matrix remodeling after assembly is linked closely to initial changes in Ca2+ and Pi to subsequent cellular hypertrophy and mineralization. These changes involve a progressive and selective removal of types II and IX collagens with the retention of the PG aggrecan.
Myxoma of the maxillary antrum in children (1993)

Myxomas of the maxillary antrum are rare tumours, particularly in childhood. Although circumscribed, they are often more extensive than apparent and so tend to recur despite their benign nature. Myxomas are gelatinous and are composed of stellate and spindle cells embedded in an abundant alcian blue-positive, mucoid stroma in which blood vessels are often scattered throughout the tumour. Three patients with maxillary myxomas, all presenting in infancy or early childhood, are described.
A 5V-only 2K × 8 dynamic RAM (1979)

A 5V-only 2K×8 dynamic RAM developed primarily for use in microprocessor systems will be discussed. The memory uses edge-activated design techniques to provide access time and power of 120ns and 150mW.
On the data analysis of light-biased photoconductance decay measurements (1996)

The use of bias light is common practice today in photoconductance decay (PCD) measurements to analyze semiconductor samples with injection-level dependent recombination parameters (i.e., surface recombination velocity and/or bulk lifetime). Recently, it has been shown on theoretical grounds that the previously reported recombination parameters from light-biased PCD experiments are not the actual properties of the investigated sample, but so-called differential recombination parameters [R. Brendel, Appl. Phys. A 60, 523 (1995)]. In the present article the theory relevant to light-biased PCD measurements is discussed in detail and subsequently applied to monocrystalline silicon wafers with nitride and oxide passivated surfaces in order to verify the deviations between the differential and actual surface recombination velocities. Special emphasis is paid to the experimental fact that the injection level cannot be reduced below a minimum value due to signal-to-noise problems.
Wind-tunnel results for a modified 17-percent-thick low-speed airfoil section (1981)

Wind-tunnel tests were conducted in the Langley low-turbulence pressure tunnel to evaluate the effects on performance of modifying a 17-percent-thick low-speed airfoil. The airfoil contour was altered to reduce the pitching-moment coefficient by increasing the forward loading and to increase the climb lift-drag ratio by decreasing the aft upper surface pressure gradient. The tests were conducted over a Mach number range from 0.07 to 0.32, a chord Reynolds number range 1.0 x 10 to the 6th power to 12.0 x 10 to the 6th power, and an angle-of-attack range from about -10 deg to 20 deg.
GIANT PILOMATRICOMA SIMULATING CARCINOMA OF THE MALE BREAST (2000)

We present the case of a 65-year-old man with a large calcifying epithelioma in the right breast. The case is unusual not only for the size of the tumour but also for its location in a male breast. Despite its large size (12 x 10 x 7 cm), the tumour did not show any clinical, radiological or histological evidence of malignancy or aggressive behaviour. One year after surgery there was no recurrence or metastatic disease. The possibility of malignancy, recurrence or metastasis of these large tumours, as well as the necessity of follow-up and investigations, are emphasised.