gebhart/patrepeval huggingface dataset:
A Combined Fuzzy-Neural Network Model for Non-Linear Prediction of 3-D Rendering Workload in Grid Computing (2004)

Implementation of a commercial application to a grid infrastructure introduces new challenges in managing the quality-of-service (QoS) requirements, most stem from the fact that negotiation on QoS between the user and the service provider should strictly be satisfied. An interesting commercial application with a wide impact on a variety of fields, which can benefit from the computational grid technologies, is three-dimensional (3-D) rendering. In order to implement, however, 3-D rendering to a grid infrastructure, we should develop appropriate scheduling and resource allocation mechanisms so that the negotiated (QoS) requirements are met. Efficient scheduling schemes require modeling and prediction of rendering workload. In this paper workload prediction is addressed based on a combined fuzzy classification and neural network model. Initially, appropriate descriptors are extracted to represent the synthetic world. The descriptors are obtained by parsing RIB formatted files, which provides a general structure for describing computer-generated images. Fuzzy classification is used for organizing rendering descriptor so that a reliable representation is accomplished which increases the prediction accuracy. Neural network performs workload prediction by modeling the nonlinear input-output relationship between rendering descriptors and the respective computational complexity. To increase prediction accuracy, a constructive algorithm is adopted in this paper to train the neural network so that network weights and size are simultaneously estimated. Then, a grid scheduler scheme is proposed to estimate the queuing order that the tasks should be executed and the most appopriate processor assignment so that the demanded QoS are satisfied as much as possible. A fair scheduling policy is considered as the most appropriate. Experimental results on a real grid infrastructure are presented to illustrate the efficiency of the proposed workload prediction--scheduling algorithm compared to other approaches presented in the literature.
A century of phage research: Bacteriophages and the shaping of modern biology (2014)

2015 marks the centennial of the discovery of bacteriophages, viruses that infect bacteria. Phages have been central to some of biology's most meaningful advances over the past hundred years (shown here); they greatly influence the workings of the biosphere, and are poised to play expanded roles in biomedicine, biotechnology, and ecology.
Seed germination and seedling emergence in Amaranthus spp. (2015)

Grain amaranth has been investigated as a new crop in Montana since 1982.Little is known about amaranth seed germination and seedling emergence responses to the environment so several studies were conducted.Amaranth seedling emergence was studied using constant temperatures between 15.3 and 45.6 C and seeding depths between 1.3 and 6.4 cm on a modified thermogradient plate and using alternating temperatures at 7-17, 10-20, and 13-23 C and seeding depths of 0.6, 1.9, and 3.2 cm in a growth chamber.Optimum constant temperatures for seedling emergence index (EI) ranged from 24.0 to 33.8 C and optimum seeding depth was 1.3 cm.Emergence index between 18.4 and 24.0 C and at 1.3 cm seeding depth may be acceptable if other conditions are favorable.EI was low from all depths at 7-17 C but was relatively high from 0.6 cm at 13-23 C. Emergence index at 10-20 C was intermediate tc EI's at the other temperatures.Recommended amaranth seeding would be at 0.6 cm and 13-23 C. Seedlot H83-438 had the largest seed and highest EI overall indicating larger seed may improve seedling emergence in cool temperatures.White and black amaranth seed and pigweed (Amaranthus retroflexus L.) seed were germinated after different periods of overwintering from November to May. White seed decomposes in cool, moist soils resulting in poor germination.Consequently, white amaranth seed would not become a weed if escaped.Black seed germinated well through the test period and could become a weed if escaped.Also, white seed would be less likely to germinate and emerge if seeded into cool soils than would black seed.Black domestic seed expressed a primary dormancy similar to but not as pronounced as the phytochrome related dormancy of pigweed seed.
Pharmacokinetic Interactions between Primaquine and Pyronaridine-Artesunate in Healthy Adult Thai Subjects (2014)

Pyronaridine-artesunate is a newly introduced artemisinin-based combination treatment which may be deployed together with primaquine. A single-dose, randomized, three-sequence crossover study was conducted in healthy Thai volunteers to characterize potential pharmacokinetic interactions between these drugs. Seventeen healthy adults received a single oral dose of primaquine alone (30 mg base) and were then randomized to receive pyronaridine-artesunate alone (540-180 mg) or pyronaridine-artesunate plus primaquine in combination, with intervening washout periods between all treatments. The pharmacokinetic properties of primaquine, its metabolite carboxyprimaquine, artesunate, its metabolite dihydroartemisinin, and pyronaridine were assessed in 15 subjects using a noncompartmental approach followed by a bioequivalence evaluation. All drugs were well tolerated. The single oral dose of primaquine did not result in any clinically relevant pharmacokinetic alterations to pyronaridine, artesunate, or dihydroartemisinin exposures. There were significantly higher primaquine maximum plasma drug concentrations (geometric mean ratio, 30%; 90% confidence interval [CI], 17% to 46%) and total exposures (15%; 6.4% to 24%) during coadministration with pyronaridine-artesunate than when primaquine was given alone. Pyronaridine, like chloroquine and piperaquine, increases plasma primaquine concentrations. (This study has been registered at ClinicalTrials.gov under registration no. NCT01552330.).
Infusions of Casein Hydrolyzates into the Mammary Gland Disrupt Tight Junction Integrity and Induce Involution in Cows (2003)

Milk stasis triggers local stimuli, which make the tight junctions leak and trigger involution. The aim of the study was to test the hypothesis that casein hydrolyzates compromise tight junction integrity and dry-off milk secretion in dairy cows. Six repeated doses of casein hydrolyzates after each milking during 3 d caused drastic changes in mammary secretion and composition, which were associated with irreversible cessation of milk secretion. No such changes were recorded in the control glands that had been treated with nonhydrolyzed casein. Treatment with casein hydrolyzates disturbed tight junction integrity within 8 h (as indicated by changes in Na+ and K+ concentrations), reduced the concentrations of lactose precipitously, activated the plasmin activator-plasminogen-plasmin system, and induced the secretion of immunoglobulin type G and lactoferrin. At the end of the 3-d treatments, we stopped milking the experimental and control glands. Milk composition 19 d later was similar in the experimental and control glands and was consistent with the composition expected in fully involuted glands. We conclude that casein hydrolyzates are among the milk-borne factors that cause the disruption of tight junction integrity and induce involution in cows. The process induced by casein hydrolyzate was more rapid and synchronized than the involution induced at drying-off.
TRANSPLANTATION OF HIGHLY DIFFERENTIATED IMMORTALIZED HUMAN HEPATOCYTES TO TREAT ACUTE LIVER FAILURE 1 (2000)

A highly differentiated immortalized human hepatocyte cell line, OUMS-29, was able to provide metabolic support during acute liver failure induced by 90% hepatectomy in rats. Essentially unlimited availability of OUMS-29 cells may be clinically useful for BAL treatment.
Nitric oxide synthesis is impaired in glutathione-depleted human umbilical vein endothelial cells (1993)

Human endothelial cells cultured from umbilical vein (HUVEC) were tested for their ability to synthesize nitric oxide (NO), which has been identified as an endothelium-derived relaxing factor. The synthesis of this free radical (detected as citrulline, which is produced stoichiometrically with NO from arginine) in HUVEC is Ca2+ dependent, is increased sevenfold by the calcium ionophore ionomycin, and accounts for most basal and ionomycin-induced guanosine 3',5'-cyclic monophosphate (cGMP) production. Loading of cells with reduced glutathione (GSH), but not with N-(2-mercaptopropionyl)- glycine (MPG), led to increased citrulline production, both basally and after ionomycin stimulation. When the cells were depleted of GSH by incubation with 1-chloro-2,4-dinitrobenzene (CDNB), citrulline synthesis and cGMP production were inhibited in a concentration-dependent way. CDNB was not cytotoxic and did not inhibit cGMP increase elicited by sodium nitroprusside; cell loading with GSH (but not with MPG) relieved the block of citrulline synthesis. These results suggest that GSH is necessary in HUVEC for NO synthesis rather than for the NO effect on guanylate cyclase.
Short bowel syndrome. (1996)

This article discusses the management of short bowel syndrome during the neonatal period. It includes information regarding etiology and pathophysiology and parenteral and enteral nutrition therapy. Finally, a discussion of the role of intestinal transplantation in the treatment of short bowel syndrome is included.
The sensitivity of flow cytometry compared with conventional cytology in the detection of superficial bladder carcinoma (1987)

Three groups of patients with superficial bladder carcinoma were studied: 110 patients had carcinoma in situ (TIS), 54 had noninvasive papillary transitional cell carcinoma (TA), and 64 had transitional cell carcinoma infiltrating the lamina propria (T1). One to six conventional cytologic examinations per patient (mean 2.8) were obtained during the 24 hour period before biopsy. For all tumor categories combined, the sensitivity was 49%, 54%, 62%, and 66% for one, two, three, and four cytologic examinations per patient, respectively. Cytologic sensitivity varied according to tumor category; it was greater in the TIS and T1 categories than in the TA category. To compare with the cytologic results, a subset of 103 patients had bladder irrigation performed immediately before the biopsy which was subsequently analyzed by flow cytometry. The sensitivity of a single flow cytometric examination for all tumor categories combined was 78%. As with the cytologic examinations, the sensitivity of flow cytometry varied with tumor category; it was greater in TIS and T1 categories than in the TA category. The sensitivity of one flow cytometric examination was superior (binomial test, P less than or equal to 0.05) to that of one or two cytologic examinations for TA tumors and to that of one, two, or three cytologic examinations for TIS, T1, and all tumor categories combined. Only three of 103 patients had their cancers detected by cytologic examination and not by flow cytometry.
Hierarchical Pore Structures through Diatom Zeolitization (2000)

The controlled construction of a microporous/macroporous materials from diatomaceous earth and a high silica zeolite by a simple method is reported. The picture shows scanning electron microscopy images of the material at two scales (left and center) and the arrangement of the zeolite crystals precipitated onto it (right). These materials have numerous potential applications in the areas of ion exchange, filtration, and catalysis.
Elements of morphology: Standard terminology for the head and face (2009)

An international group of clinicians working in the field of dysmorphology has initiated the standardization of terms used to describe human morphology. The goals are to standardize these terms and reach consensus regarding their definitions. In this way, we will increase the utility of descriptions of the human phenotype and facilitate reliable comparisons of findings among patients. Discussions with other workers in dysmorphology and related fields, such as developmental biology and molecular genetics, will become more precise. Here we introduce the anatomy of the craniofacies and define and illustrate the terms that describe the major characteristics of the cranium and face.
Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail (1996)

The full-length primary structure and expression profile of a novel unconventional myosin heavy chain, human myosin-IXb, is described. The primary structure of this myosin predicts a 229 kDa protein that together with its recently described rat homolog, myr 5, is the ninth class of myosins to be identified. In comparison to skeletal muscle myosin-II, the myosin-IXb 'head' has two unusual features: a novel N-terminal domain of 140 amino acids, which includes a 60 amino acid extension, and a large insertion of 126 amino acids in the putative actin-binding site. The 'neck' contains four tandemly repeated IQ motifs, suggesting that this myosin may have four associated light chains. The 'tail' contains a region similar to regions found in the chimerins, with a putative zinc and diacylglycerol binding domain, homologous to the regulatory domain of protein kinase C and a putative GTPase-activating protein (GAP) domain of the rho/rac family of ras-like G-proteins. Northern blot analysis of 16 different human tissues revealed an approximately 8 kb transcript that is most highly expressed in peripheral blood leukocytes, with somewhat lower levels of expression in thymus and spleen, suggesting that myosin-IXb is most abundant in cells of myeloid origin. Myosin-IXb was also expressed in a number of other tissues at significantly lower levels. Analysis of myosin-IXb protein expression, using a tail-domain directed antibody, was performed in HL-60 cells, a human leukocyte cell. Myosin-IXb expression increases by 4- to 5-fold upon induced differentiation of these cells into macrophage-like cells. The localization of myosin-IXb is also altered upon differentiation. In undifferentiated HL-60 cells, myosin-IXb colocalizes with F-actin in the cell periphery, while in differentiated cells its localization becomes more cytoplasmic, with the highest levels in the perinuclear region.
Pharmacokinetics and Platelet Antiaggregating Effects of Beraprost, an Oral Stable Prostacyclin Analogue, in Healthy Volunteers (1993)

Beraprost sodium (BPS) is an orally stable analogue of prostacyclin that inhibits adenylate-cyclase-dependent platelet aggregation and is proposed for treatment of chronic arterial occlusion. To determine the duration and intensity of platelet antiaggregation with BPS, 12 healthy, nonsmoking, male white volunteers participated in a double-blind, dose-escalating design with randomized placebo, placebo-controlled, cross-over study. After overnight fasting, single (20, 40, 60 micrograms and placebo) and repeated [20, 40, 60 micrograms and placebo) and repeated [20, 40, 60 micrograms and placebo three times daily (t.i.d.) for 3 days] oral doses of BPS were administered. Mean percentage of inhibition of ADP-induced aggregation normalized to placebo was measured for 8 h after drug administration and related to plasma concentrations (Cp) of the active enantiomer (APS 314d). BPS 40 and 60 micrograms decreased platelet aggregation 1 h after single doses, and 0.5 h and 1 h after repeated doses. BPS 20 micrograms had no significant effect. APS 314d pharmacokinetics was linear, and its terminal half-life (t 1/2) ranged from 0.50 +/- 0.21 to 0.91 +/- 0.27 h (mean +/- SD) independently of BPS dose. Antiaggregating effects were poorly related to Cp of APS 314d (r2 < or = 0.2). Some subjects complained of moderate postdrug absorption headaches (7 of 12 after single and 8 of 12 after repeated doses) and flushes (6 of 12 and 7 of 12, respectively). These data indicate that orally active prostacyclin BPS (40 or 60 micrograms) exerts its maximal antiaggregating effects between 0.5 and 1 h.
Variability over time of complement activation induced by air bubbles in human and rabbit sera (1993)

Complement activation induced by air bubbles in rabbit and human sera was studied by measuring the generation of anaphylatoxin des-Arg-C5a. des-Arg-C5a was quantified by sandwich enzyme-linked immunosorbent assays based on neoepitope-specific anti-des-Arg-C5a monoclonal antibodies. Air bubbles were continuously introduced to serum via a calibrated microflowmeter, and the serum was incubated at 37 degrees C for 30 min. Air bubbles clearly generated increased amounts of des-Arg-C5a compared with corresponding levels in control serum, and a dose-dependent effect was also noted. Strong positive correlations between des-Arg-C5a concentrations in control sera and sera incubated with air bubbles at a flow of 0.5 ml/min were found. To study variation over time, serum was obtained at regular intervals from six rabbits and from six healthy humans during 66- and 196-day periods, respectively. A pronounced intraindividual variability over time was thus observed. The reason for the large variability is at present unknown. We conclude that the sensitivity of complement to activation by air bubbles is not an inherent, static feature of the complement system of an individual. Therefore single-point analysis of complement activation by air bubbles appears to be an inappropriate parameter by which to differentiate a "sensitive" or "insensitive" complement system between individuals.
Integrative Systemic and Local Metabolomics with Impact on Survival in High-Grade Serous Ovarian Cancer (2016)

<b>Purpose:</b> Cancer metabolism is characterized by alterations including aerobic glycolysis, oxidative phosphorylation, and need of fuels and building blocks.<b>Experimental Design:</b> Targeted metabolomics of preoperative and follow-up sera, ascites, and tumor tissues, RNA sequencing of isolated tumor cells, local and systemic chemokine, and local immune cell infiltration data from up to 65 high-grade serous ovarian cancer patients and 62 healthy controls were correlated to overall survival and integrated in a Systems Medicine manner.<b>Results:</b> Forty-three mainly (poly)unsaturated glycerophospholipids and four essential amino acids (citrulline) were significantly reduced in patients with short compared with long survival and healthy controls. The glycerophospholipid fingerprint is identical to the fingerprint from isolated (very) low-density lipoproteins (vLDL), indicating that the source of glycerophospholipids consumed by tumors is (v)LDL. A glycerophospholipid-score (HR, 0.46; <i>P</i> = 0.007) and a 100-gene signature (HR, 0.65; <i>P</i> = 0.004) confirmed the independent impact on survival in training (<i>n</i> = 65) and validation (<i>n</i> = 165) cohorts. High concentrations of LDLs and glycerophospholipids were independently predictors for favorable survival. Patients with low glycerophospholipids presented with more systemic inflammation (C-reactive protein and fibrinogen negatively and albumin positively correlated) but less adaptive immune cell tumor infiltration (lower tumor and immune cell PD-L1 expression), less oxygenic respiration and increased triglyceride biosynthesis in tumor cells, and lower histone expressions, correlating with higher numbers of expressed genes and more transcriptional noise, a putative neo-pluripotent tumor cell phenotype.<b>Conclusions:</b> Low serum phospholipids and essential amino acids are correlated with worse outcome in ovarian cancer, accompanied by a specific tumor cell phenotype. <i>Clin Cancer Res; 23(8); 2081-92. ©2016 AACR</i>.
Draft Genome Sequences of Methanobrevibacter curvatus DSM11111, Methanobrevibacter cuticularis DSM11139, Methanobrevibacter filiformis DSM11501, and Methanobrevibacter oralis DSM7256 (2016)

Here, the draft genome sequences of four different Methanobrevibacter species are presented. Three of the Methanobrevibacter species (M. curvatus, M. cuticularis, and M. filiformis) have been isolated from the termite hindgut, while M. oralis was isolated from human subgingival plaque.
Dynamic Omnidirectional Texture Synthesis for Photorealistic Virtual Content Creation (2018)

We present a dynamic omnidirectional texture synthesis (DOTS) approach for generating real-time virtual reality content captured using a consumer-grade RGB-D camera. Compared to a single fixed-viewpoint color map, view-dependent texture mapping (VDTM) techniques can reproduce finer detail and replicate dynamic lighting effects that become especially noticeable with head tracking in virtual reality. However, VDTM is very sensitive to errors such as missing data or inaccurate camera pose estimation, both of which are commonplace for objects captured using consumer-grade RGB-D cameras. To overcome these limitations, our proposed optimization can synthesize a high resolution view-dependent texture map for any virtual camera location. Synthetic textures are generated by uniformly sampling a spherical virtual camera set surrounding the virtual object, thereby enabling efficient real-time rendering for all potential viewing directions.
Prenatal monitoring of ornithine transcarbamoylase deficiency in two families by DNA analysis (1992)

We examined the DNA in two families with ornithine transcarbamoylase (OTC) deficiency. Two point mutations of the OTC gene, a C-to-T (codon 141) and a G-to-A (codon 141), were identified. This allowed prenatal monitoring to be made for two fetuses in each family, using polymerase chain reaction (PCR), followed by allele-specific oligonucleotide hybridization or TaqI digestion of amplified sequence. The diagnoses showed heterozygotes of a wild type gene and the corresponding mutant gene in these fetuses; each was confirmed postnatally.
Experimental Study and Computer Modeling of the Triple Point of Argon System (2012)

The triple point of argon is a defined fixed point in ITS-90 for calibration of standard platinum resistance thermometers (SPRTs). A new triple point of argon system with multiple re-entrant wells ...
A new glass‐ceramic for bone replacement: Evaluation of its bonding to bone tissue (1985)

Glass powders (350 mesh) of the composition MgO, 4.6; CaO, 44.9; SiO, 34.2; PO, 16.3; CaF, 0.5 in weight ratio were compacted, heated to 1050 degrees C at a rate of 5 degrees C/min and kept at 1050 degrees C for 2 h. The resultant glass-ceramic having oxyapatite, fluoroapatite, and wollastonite crystals showed high bending and compressive strengths of 157 and 1060 MPa, respectively. The biocompatibility and bonding ability of this new glass-ceramic to the bone tissue was evaluated using rabbit tibial bones, and the failure load to break the bonding of several ceramics (the new glass-ceramic, dense hydroxyapatite, 45S5 Bioglass, alumina-ceramic) to bone tissues was measured. The new glass-ceramic showed tight bonding to bone comparable with dense hydroxyapatite, and in 25 weeks its load was 70% of that of bone tissue.