gebhart/patrepeval huggingface dataset:
Nerve Growth Factor–specific Regulation of Protein Methylation during Neuronal Differentiation of PC12 Cells (1997)

Protein methylation is a posttranslational modification that can potentially regulate signal transduction pathways in a similar manner as protein phosphorylation. The role of protein methylation in NGF signaling was examined by metabolic labeling of PC12 cell proteins with L-[methyl-3H]methionine and by in vitro labeling of cell proteins with L-[methyl-3H]S-adenosylmethionine. Effects of NGF were detected within 15 min. Methyl-labeled proteins were resolved by one and two dimensional SDS-PAGE. NGF affected the methylation of several 68-60-kD proteins (pI 5.8-6.4) and 50-kD proteins (isoelectric point pH 6.7-6.8 and 5.8-6.2). Several NGF-induced changes in methylation increased over several hours and through 4 d. Moreover, methyl labeling of several specific proteins was only detected after NGF treatment, but not in nontreated controls. The effects of NGF on protein methylation were NGF specific since they were not observed with EGF or insulin. A requirement for protein methylation for neurite outgrowth was substantiated with either of two methylation inhibitors: dihydroxycyclopentenyl adenine (DHCA) and homocysteine. DHCA, the more potent of the two, markedly inhibits protein methylation and neurite outgrowth without affecting cell growth, NGF-induced survival, cell flattening, or several protein phosphorylations that are associated with early signaling events. Removal of DHCA leads to rapid protein methylation of several proteins and concurrent neurite outgrowth. The results indicate that NGF regulates the methylation of several specific proteins and that protein methylation is involved in neurite outgrowth from PC12 cells.
A portable, arbitrary waveform, multichannel constant current electrotactile stimulator (2017)

In this paper, we present the design and performance of a portable, arbitrary waveform, multichannel constant current electrotactile stimulator that costs less than $30 in components. The stimulator consists of a stimulation controller and power supply that are less than half the size of a credit card and can produce ±15 mA at ±150 V. The design is easily extensible to multiple independent channels that can receive an arbitrary waveform input from a digital-to-analog converter, drawing only 0.9 W/channel (lasting 4-5 hours upon continuous stimulation using a 9 V battery). Finally, we compare the performance of our stimulator to similar stimulators both commercially available and developed in research.
Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression (2017)

Mitochondrial DNA (mtDNA) mutations and polymorphisms contribute to many complex diseases, including cancer. Using a unique mouse model that contains nDNA from one mouse strain and homoplasmic mitochondrial haplotypes from different mouse strain(s)-designated Mitochondrial Nuclear Exchange (MNX)-we showed that mtDNA could alter mammary tumor metastasis. Because retrograde and anterograde communication exists between the nuclear and mitochondrial genomes, we hypothesized that there are differential mtDNA-driven changes in nuclear (n)DNA expression and DNA methylation. Genome-wide nDNA methylation and gene expression were measured in harvested brain tissue from paired wild-type and MNX mice. Selective differential DNA methylation and gene expression were observed between strains having identical nDNA, but different mtDNA. These observations provide insights into how mtDNA could be altering epigenetic regulation and thereby contribute to the pathogenesis of metastasis. <i>Cancer Res; 77(22); 6202-14. ©2017 AACR</i>.
Knock Detection Using Spectral Analysis Techniques on a Texas Instruments TMS320 DSP (1996)

<div class="htmlview paragraph">An efficient method of detecting engine knock using spectral analysis is presented. Multiple single-point DFTs are used to condition the measured knock signal. Using multiple frequencies in the detection algorithm provides a better signature of the combustion process and enhances the ability to detect low-level knock across the entire operating range of the engine. The detection strategy compares the DFT outputs to a variable reference to determine a knock intensity metric. Unlike currently used techniques, the algorithm adapts the reference (no-knock condition) to varying engine speeds and loads. An overview of the knock detection problem and current technology is presented.</div>
Facile Synthesis and Characterization of Naphthidines as a New Class of Highly Nonplanar Electron Donors Giving Robust Radical Cations (2006)

Naphthidines 2 were prepared by nickel-catalyzed amination of 1-chloronaphthalene followed by oxidative homocoupling of 1-naphthalene amines 1 using titanium(IV) tetrachloride. The electronic and magnetic properties of materials 2 were investigated by cyclic voltammetry and other electrochemical techniques, EPR and UV-visible spectroscopies, and magnetic susceptibility. It was demonstrated that compounds 2 could be easily and reversibly oxidized via a two-electron-transfer reaction into their bis(radical cation) 2(2.2+), which displays a substantial stability at room temperature (the half-life of 2(2.2+) estimated by EPR at 25 degrees C was 10 days). B3LYP/6-31G optimized structures of N,N'-bis(4-methoxyphenyl)-(1,1'-binaphthyl)-4,4'-diamine 2g shows significant differences in the torsion angle between the naphthalene moieties depending on its oxidation state. Twisted structures are preferred for neutral compounds, whereas more planar are favored for the oxidized forms 2g*+ and 2g(2.2+) to realize spin and/or charge delocalizations over the whole pi-system. Such conformation changes concerted with the electron transfers contribute to explain the unusual two-electron process observed in the electrochemical behavior of 2g instead of the two single-electron transfers that would have been expected in the case of two successive oxidations. It is finally shown that the oxidation of 2g in CH2Cl2 with thianthrenium perchlorate (ThClO4) generates the dication 2g(2.2+) with singlet spin-multiplicity.
Joint Parameter Estimation of Two-Dimensional Angle/Delay/Polarization for Multipath Channels (2008)

In this paper, a novel method is proposed for joint two-dimensional angle, delay and polarization estimation in multipath channels. A uniform planar array of crossed dipoles is employed to measure the signals of arrival. Unlike those previous joint estimation methods that only involve angle/delay or angle/polarization or one-dimensional angle/delay/polarization, the method can effectively estimate elevation, azimuth, delay and polarization via the shift invariance structure of ESPRIT algorithm and based on polarization diversity. Also, it avoids peak search and reduces the computational cost. The method can be applied in time-division system in which the paths are close spatially. The obtained space-time channel parameters are helpful for accurate three-dimensional (3-D) wireless localization. The simulations show that the use of the proposed method can provide high-resolution estimates.
Cloning and expression of bovine corneal antigen cDNA (1997)

The isolation and analysis of a cDNA clone containing the complete coding sequence of the CO-Ag protein and the expression of the CO-Ag protein in E. coli is reported. The availability of a CO-Ag cDNA probe and larger quantities of the CO-Ag protein should aid in elucidating the possible pathogenic role of CO-Ag in Mooren's ulcer.
Glycogen content of rat pancreatic islet cell tumors produced by the combined action of streptozotocin and nicotinamide (2003)

info:eu-repo/semantics/published
Miniaturization of <i>p </i>-Ge lasers: Progress toward continuous wave operation (1996)

We have observed intervalence band laser action in Al-doped germanium crystals with volumes as small as 0.03 cm3, one order of magnitude smaller than previously studied p-Ge laser crystals. A duty cycle of 1.5×10−4 was achieved. We show evidence that crystal heating plays a key role in the duration of the emission pulse and have measured a maximum pulse length of 11 μs for a 0.43 cm3, Ga-doped germanium crystal. Such progress in the understanding and performance of p-Ge hot hole lasers marks a significant step toward continuous wave operation.
Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7. (1986)

Pancreatic polypeptide and neuropeptide Y share 50% amino acid homology (18 out of 36 residues), suggesting that they may have common ancestral origins. cDNA clones complementary to human mRNAs encoding pancreatic polypeptide and neuropeptide Y were used to detect specific human genomic DNA sequences in human-mouse somatic cell hybrid lines. The pancreatic polypeptide gene (PPY) segregated with human chromosome 17, while the neuropeptide Y gene (NPY) segregated with human chromosome 7. Examination of cell hybrids with chromosomal rearrangements assigned PPY to the p11.1-qter region and NPY to the pter-q22 region of their respective chromosomes.
Effects of temperature and defects on breakdown lifetime of thin SiO/sub 2/ at very low voltages (1994)

This paper investigates the physics of voltage and temperature accelerated breakdown testing of silicon dioxide within the framework of an anode hole injection model which can predict low voltage (3.3 V and below) breakdown lifetime. The field acceleration rate is shown to be independent of temperature, while the reduction of oxide breakdown lifetime at increased temperature is due to the oxide's enhanced susceptibility to damage caused by the holes' transport through the oxide. This paper also investigates defect related breakdown, showing that defects can be mathematically modeled as effective thinning even for aggressively scaled oxides. The effective thickness statistic derived from ramp breakdown or high-field lifetime or charge-to-breakdown tests enables determination of the oxide integrity of a specific oxide technology. For 3.3 V operation, an oxide technology must provide an effective thickness of 44 /spl Aring/; for 2.5 V operation, 34 /spl Aring/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Causal Falling Rule Lists (2015)

A causal falling rule list (CFRL) is a sequence of if-then rules that specifies heterogeneous treatment effects, where (i) the order of rules determines the treatment effect subgroup a subject belongs to, and (ii) the treatment effect decreases monotonically down the list. A given CFRL parameterizes a hierarchical bayesian regression model in which the treatment effects are incorporated as parameters, and assumed constant within model-specific subgroups. We formulate the search for the CFRL best supported by the data as a Bayesian model selection problem, where we perform a search over the space of CFRL models, and approximate the evidence for a given CFRL model using standard variational techniques. We apply CFRL to a census wage dataset to identify subgroups of differing wage inequalities between men and women.
Mechanisms of Alkyl Sulfonate Adsorption at the Alumina-Water Interface<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanisms of Alkyl Sulfonate Adsorption at the Alumina-Water Interface1P. Somasundaran and D. W. FuerstenauCite this: J. Phys. Chem. 1966, 70, 1, 90–96Publication Date (Print):January 1, 1966Publication History Published online1 May 2002Published inissue 1 January 1966https://pubs.acs.org/doi/10.1021/j100873a014https://doi.org/10.1021/j100873a014research-articleACS PublicationsRequest reuse permissionsArticle Views1385Altmetric-Citations546LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Familial cortical myoclonus with a mutation in <i>NOL3</i> (2012)

We propose that familial cortical myoclonus is a novel movement disorder that may be caused by mutation in NOL3. Further investigation of the role of NOL3 in neuronal physiology may shed light on neuronal membrane hyperexcitability and pathophysiology of myoclonus and related disorders.
A probabilistic model for camera zoom detection (2003)

Camera motion detection is essential for automated video analysis. We propose a new probabilistic model for detecting zoom-in/zoom-out operations. The model uses EM to estimate the probability of a zoom versus a non-zoom operation from standard MPEG motion vectors. Traditional methods usually set an empirical threshold after deriving parameters proportional to zoom, pan, rotate and tilt. In contrast, our probabilistic model has a solid probabilistic foundation and a clear, simple probability threshold. Experiments show that this probabilistic model significantly out-performs a baseline parametric method for zoom detection in both precision and recall.
Toner Display Based on Particle Movements (2002)

A novel electronic reflective display using conductive toners and dielectric white particles has been designed and constructed. The display cell consists of two indium−tin oxide (ITO) plates coated with a charge-transport layer (CTL) on the interior of the cell. The toner and white particles are placed in a small space formed by a spacer. In this display, toner movement is controlled by the action of an external electric field applied between the two ITO electrodes. The conductive toners in the vicinity of the CTL on the anode (lower electrode) are charged positively by hole injection from the CTL and then move to the cathode (upper electrode) to form a black image. The toner is held on the CTL of the cathode by an electrostatic force. A white image is formed by applying a reverse electric field that causes the toners to move back to the lower electrode. The reflection densities of the black and white images were determined to be 0.96 and 0.63, respectively. A response time of ca. 0.8 ms was obtained under optimal operating conditions. Observations of the image formation, optimization of particle-loading conditions, and investigation of the repetition characteristics of the display have been carried out.
Visualization of conflicts and resolutions in a "Free Flight" scenario (1999)

"Free Flight" will change today's air traffic control system by giving pilots increased flexibility to choose and modify their routes in real time, reducing costs and increasing system capacity. This increased flexibility comes at the price of increased complexity. If Free Flight is to become a reality, future air traffic controllers, pilots, and airline managers will require new conflict detection, resolution and visualization decision support tools. The paper describes a testbed system for building and evaluating such tools, including its current capabilities, lessons we learned and feedback received from expert users. The visualization system provides an overall plan view supplemented with a detailed perspective view, allowing a user to examine highlighted conflicts and select from a list of proposed solutions, as the scenario runs in real time. Future steps needed to improve this system are described.
Electron cyclotron heating experiments on the JFT-2 tokamak using an inside launch antenna (1982)

An electron cyclotron heating experiment is described in which 28 GHz microwave power is launched from the high field side (inside) of a tokamak discharge from a steerable phased array antenna exciting the extraordinary mode. The central temperature was doubled (from 600 eV to 1200 eV) with a power at the antenna approximately two-thirds the Ohmic input. An oblique launch of the extraordinary mode was found to heat more efficiently and to a higher density than either the perpendicularly launched extraordinary mode or the ordinary mode launched from the outside.
Potency-matched Dual Cytokine–Antibody Fusion Proteins for Cancer Therapy (2017)

A novel biopharmaceutical, consisting of the F8 mAb (specific to a splice isoform of fibronectin) simultaneously fused to both TNF and IL2, was found to react with the majority of solid tumors and hematologic malignancies in mouse and man, but not with healthy adult tissues. The product selectively localized to neoplastic lesions <i>in vivo</i>, as evidenced by quantitative biodistribution studies using radioiodinated protein preparations. When the potency of the cytokine payloads was matched by a single-point mutation, the resulting fusion protein (IL2-F8-TNF<sup>mut</sup>) eradicated soft-tissue sarcomas in immunocompetent mice, which did not respond to individual antibody-cytokine fusion proteins or by standard doxorubicin treatment. Durable complete responses were also observed in mice bearing CT26, C1498, and F9 tumors. The simultaneous delivery of multiple proinflammatory payloads to the cancer site conferred protective immunity against subsequent tumor challenges. A fully human homolog of IL2-F8-TNF<sup>mut</sup>, which retained selectivity similar to its murine counterpart when tested on human material, may open new clinical applications for the immunotherapy of cancer. <i>Mol Cancer Ther; 16(11); 2442-51. ©2017 AACR</i>.
Multilayer film elements for clinical analysis: applications to representative chemical determinations. (1978)

Using the general concept of a dry multilayer analytical element, we can change chemical procedures and configurations to assay several blood components. In the assay of serum urea nitrogen, urease in the reagent layer catalyzes the hydrolysis of urea. A semipermeable membrane excludes aqueous base, but allows ammonia to diffuse to an underlying indicator layer. For the amylase determination, the enzyme hydrolyzes a dyed-starch substrate coated on top of the spreading layer; this produces small fragments, which diffuse to a registration layer. The increase of absorbance at 540 nm is correlated with amylase activity. Bilirubin complexes with a cationic polymer at the interface between the spreading and reagent layers. The direct reading at 460 nm allows determination of total bilirubin in the range 1 to 500 mg/liter. Tirglycerides are hydrolyzed in the spreading layer, and the resulting soluble glycerol readily diffuses into the reagent layer, where it is phosphorylated and subsequently oxidized by glycerophosphate oxidase to yield dihydroxyacetone phosphate and hydrogen peroxide. Peroxidase catalyzes production of a color commensurate with the hydrogen peroxide produced.
Reconsidering the Ocampo Caves and the Era of Incipient Cultivation in Mesoamerica (1997)

In northeastern Mexico, near Ocampo, Romero’s and Valenzuela’s caves have been central to explanations of agricultural origins in Mesoamerica for more than four decades. Along with caves in Tehuacán and Oaxaca, these "Ocampo caves" have provided almost all of the available evidence for the initial appearance of a number of key Mesoamerican crop plants, including maize, beans, and squash. This article reanalyzes the cultural and temporal context of five crop plant assemblages in the Ocampo caves: maize (Zea mays), bottle gourd (Lagenaria siceraria), and three species of squash (Cucurbita argyrosperma, C. moschata, C. pepo). Fifteen AMS radiocarbon dates on early domesticates both confirm the stratigraphic integrity of the two caves and substantially revise the temporal framework for initial appearance of core domesticates in northeastern Mexico, showing the transition to food production in Tamaulipas took place more recently than previously thought. A substantially foreshortened chronology for Ocampo crop plants confirms the northern periphery role of Tamaulipas in the origins of agriculture in Mexico, while also underscoring the need for establishing AMS-based archaeobotanical sequences across Mesoamerica to gain an adequate context for understanding the temporal, environmental, and cultural contexts of initial plant domestication in the region.
Revenue maximizing itemset construction for online shopping services (2013)

Purpose Revenue maximization through improving click‐throughs is of great importance for price comparison shopping services (PCSSs) whose revenues directly depend on the number of click‐throughs of items in their itemsets. The purpose of this paper is to present an approach aiming to maximize the revenue of a PCSS by proposing effective itemset construction methods that can maximize the click‐throughs. Design/methodology/approach The authors suggest three itemset construction methods, namely naïve method (NM), exhaustive method (EM), and local update method (LM). Specifically, NM searches for the best itemset for an item in terms of textual similarity between an item and an itemset, while EM produces the best itemset for each item for maximizing click‐throughs by considering all the possible memberships of the item. Finally, through combining NM and EM, the authors propose an LM that attempts to improve click‐throughs by locally updating the memberships of items according to their ranks in each itemset. Findings Through evaluation of the proposed methods based on a real‐world dataset, it has been found that improvement of click‐throughs is small when itemsets are constructed by using the textual similarity alone. However, significant improvement in the number of click‐throughs was achieved when considering items' membership updates dynamically. Originality/value Unlike the previous studies that mainly focus on the textual similarity, the authors attempt to maximize the revenue through constructing itemsets that can result in more click‐throughs. By using the proposed methods, it is expected that PCSSs will be able to automatically construct itemsets that can maximize their revenues without the need for manual task.
Broadband tonpilz underwater acoustic transducers based on multimode optimization (1997)

Head flapping has often been considered to be deleterious for obtaining a tonpilz transducer with broadband, high power performance. In the present work, broadband, high power tonpilz transducers have been designed using the finite element (FE) method. Optimized vibrational modes including the flapping mode of the head are effectively used to achieve the broadband performance. The behavior of the transducer in its longitudinal piston mode and in its flapping mode is analysed for in-air and in-water situations. For the 37.8% bandwidth of the center frequency from 28.5 to 41.8 kHz, the amplitude variation of the transmitting voltage response (TVR) does not exceed /spl plusmn/2 dB and a maximum TVR of 146.8 dB (ref. 1 /spl mu/Pa/volt at 1 meter) is obtained. Reasonable agreement between the experimental results and the numerical results is achieved. A maximum sound pressure level of 214.8 dB can be expected. Further numerical calculation indicates that there is potential for increasing the bandwidth by varying other parameters in the design.