gebhart/patrepeval huggingface dataset:
Pharmaceutical Isothermal Calorimetry (2006)

Pharmaceutical Isothermal Calorimetry discusses the application of isothermal calorimetric techniques to challenges encountered during the rational design and development of novel drugs and drug delivery systems. Providing a comprehensive review of recent research and trends, this book contains an expert discussion of research and applications to p
Human transfer factor: fractionation by electrofocusing and high pressure, reverse phase chromatography. (1977)

The biologically active fraction of human transfer factor (Sephadex G-25, fraction III) has been separated by exclusion chromatography into two component fractions (IIIa and IIIb). Fraction IIIa transferred donor reactivities to PPD or KLH into 9 of 9 recipients. Fraction IIIb did not transfer donor reactivities (0 of 8 transfers) but did produce both antigen-independent and antigen-dependent dermal reactions in recipients. Fractionation by electrofocusing and high pressure reverse phase chromatography revealed that IIIa has a major UV254 absorbing component and that fraction IIIb has at least three major and three minor UV absorbing components. The major component of IIIa was isolated by preparative electrofocusing, had an isoelectric point of 1.6, and transferred KLH reactivity to four of five recipients.
Theory of Secondary Electron Cascade in Metals (1954)

A study is made of the cascade process which describes the diffusion, energy loss, and multiplication of secondary electrons within a metal. The secondaries interact mainly with conduction electrons through a screened Coulomb potential. For low secondary energy (50 ev) the resultant scattering is nearly spherically symmetric and the transport equation which governs the cascade process can be approximately solved. The velocity distribution turns out to be spherically symmetric for low secondary energy. Energy distributions are in agreement with experiment for metals to which the theory is applicable. Calculations are also made of the rate of change of yield with work function and the results are in accord with observed values. Finally, rough estimates are made of the total yield and the theory is shown to be consistent with the observed values.
Random Mutagenesis of the Multidrug Transporter AcrB from Escherichia coli for Identification of Putative Target Residues of Efflux Pump Inhibitors (2014)

Efflux is an important mechanism of bacterial multidrug resistance (MDR), and the inhibition of MDR pumps by efflux pump inhibitors (EPIs) could be a promising strategy to overcome MDR. 1-(1-Naphthylmethyl)-piperazine (NMP) and phenylalanine-arginine-β-naphthylamide (PAβN) are model EPIs with activity in various Gram-negative bacteria expressing AcrB, the major efflux pump of Escherichia coli, or similar homologous pumps of the resistance-nodulation-cell division class. The aim of the present study was to generate E. coli AcrB mutants resistant to the inhibitory action of the two model EPIs and to identify putative EPI target residues in order to better understand mechanisms of pump inhibition. Using an in vitro random mutagenesis approach focusing on the periplasmic domain of AcrB, we identified the double mutation G141D N282Y, which substantially compromised the synergistic activity of NMP with linezolid, was associated with similar intracellular linezolid concentrations in the presence and absence of NMP, and did not impair the intrinsic MICs of various pump substrates and dye accumulation. We propose that these mutations near the outer face of the distal substrate binding pocket reduce NMP trapping. Other residues found to be relevant for efflux inhibition by NMP were G288 and A279, but mutations at these sites also changed the susceptibility to several pump substrates. Unlike with NMP, we were unable to generate AcrB periplasmic domain mutants with resistance or partial resistance to the EPI activity of PAβN, which is consistent with the modes of action of PAβN differing from those of NMP.
Microencapsulation of Flavors in Carnauba Wax (2010)

The subject of this study is the development of flavor wax formulations aimed for food and feed products. The melt dispersion technique was applied for the encapsulation of ethyl vanillin in wax microcapsules. The surface morphology of microparticles was investigated using scanning electron microscope (SEM), while the loading content was determined by HPLC measurements. This study shows that the decomposition process under heating proceeds in several steps: vanilla evaporation occurs at around 200 °C, while matrix degradation starts at 250 °C and progresses with maxima at around 360, 440 and 520 °C. The results indicate that carnauba wax is an attractive material for use as a matrix for encapsulation of flavours in order to improve their functionality and stability in products.
Novel Coronavirus (2019-nCoV) in Disguise (2020)

Novel coronavirus (2019-nCoV) pandemic is currently one of the most influential topics as it not only impacts the field of medicine but most importantly, it affects the lives of many individuals throughout the world. We report an interesting 2019-nCoV case in a tertiary community hospital with the initial concern of acute pyelonephritis without respiratory symptoms that ultimately led to the quarantine of a number of healthcare providers. This case emphasizes the importance of radiological evidence in diagnosing 2019-nCoV in the setting of an initial atypical presentation. It also serves as an example of how healthcare providers may need to increase their suspicion for COVID-19 to ensure self-protection and prompt diagnosis in the era of an ongoing pandemic.
The Use of Vanishing Point for the Classification of Reflections From Foreground Mask in Videos (2009)

Extraction of foreground is a basic task in surveillance video analysis. In most real cases, its performance is heavily based on the efficiency of shadow detection and on the analysis of lighting conditions and reflections caused by mirrors or other reflective surfaces. This correspondence is focused on the improvement of foreground extraction in the case of planar reflective surfaces. We show that the geometric model of a scene with a planar reflective surface is reduced to the estimation of vanishing-point for the case of an auto-epipolar (skew-symmetric) fundamental matrix. The correspondences for the vanishing-point estimation are extracted from motion statistics. The knowledge of the position of the vanishing point allows us to integrate the geometric model and the motion statistics into image foreground-extraction to separate foreground from reflections, and thus to achieve better performance. The experiments confirm the accuracy of the vanishing point and the improvement of the foreground image mask by removing reflected object parts.
A Cluster-Based Distributed Active Current Sensing Circuit for Hardware Trojan Detection (2014)

The globalization of integrated circuits (ICs) design and fabrication has given rise to severe concerns on the devastating impact of subverted chip supply. Hardware Trojan (HT) is among the most dangerous threats to defend. The dormant circuit inserted stealthily into the chip by the advisory could steal the confidential information or paralyze the system connected to the subverted chip upon the HT activation. This paper presents a transient power supply current sensor to facilitate the screening of an IC for HT infection. Based on the power gating scheme, it converts the current activity on local power grid into a timing pulse from which the timing and power-related side channel signals can be externally monitored by the existing scan test architecture. Its current comparator threshold can be calibrated against the quiescent current noise floor to reduce the impacts of process variations. Postlayout statistical simulations of process variations are performed on the ISCAS'85 benchmark circuits to demonstrate the effectiveness of the proposed technique for the detection of delay-invariant and rarely switched HTs. Compared with the detection error rate of a 4-bit counter-based HT reported by an existing HT detection method using the path delay fingerprint, our method shows an order of magnitude improvement in the detection accuracy.
Inhibitor of protein synthesis blocks longterm behavioral sensitization in the isolated gill‐withdrawal reflex of <i>Aplysia</i> (1989)

To study the effects of protein synthesis inhibition on long-term sensitization of the gill- and siphon-withdrawal reflex of Aplysia, we have developed an isolated reflex preparation in which we could expose the inhibitor to only that part of the central nervous system involved in mediating the reflex and not to the other parts of the animal's central nervous system, thus minimizing the possible systemic side effects. We have found that long-term sensitization can be obtained in the isolated gill reflex, and that this long-term process, but not the short-term process, is blocked selectively by anisomycin, a reversible inhibitor of protein synthesis. Moreover, to obtain this blockade of long-term sensitization, this drug need only be applied during the training procedure.
THE KINETICS OF BASIC HYDROLYSIS OF SOME γ-LACTONES AND γ-THIOLACTONES IN AQUEOUS ACETONE<sup>1</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE KINETICS OF BASIC HYDROLYSIS OF SOME γ-LACTONES AND γ-THIOLACTONES IN AQUEOUS ACETONE1CHARLES M. STEVENS and D. STANLEY TARBELLCite this: J. Org. Chem. 1954, 19, 12, 1996–2003Publication Date (Print):December 1, 1954Publication History Published online1 May 2002Published inissue 1 December 1954https://pubs.acs.org/doi/10.1021/jo01377a017https://doi.org/10.1021/jo01377a017research-articleACS PublicationsRequest reuse permissionsArticle Views507Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Complete Primary Structure of the 3 Chain From the Hemoglobin of a Baboon,<u>Papio cynocephalus</u> (1980)

The complete primary structure of the beta chain from the adult hemoglobin of a baboon, Papio cynocephalus, has been determined by automated, Edman degradation of the intact chain and four fragments derived therefrom by specific cleavage reactions. The analysis was facilitated by application of a modified solvent system that permits unambiguous identification, by high-performance liquid chromatography, of the 17 amino acids whose phenylthiohydantoin derivatives are soluble in ethyl acetate. The sequence obtained differs from that of the human beta chain at eight sites, a degree of divergence similar to that observed when human and macaque beta chains are compared. Of the cercopithecoid beta chains whose complete sequences have been determined or inferred from compositions of small peptides, that of P. cynocephalus is most like the beta chain of the gelada baboon, an observation in accord with assessment of a close phylogenetic relationship between the genera Papio and Theropithecus.
A Mass Spectrometer for the Simultaneous Measurement of the Neutral and the Ion Composition of the Upper Atmosphere (1971)

A mass spectrometer is described which measures the neutral and the ionized components of the upper atmosphere simultaneously (delay ∼20 msec). Its 1% mass resolution is 60 and its sensitivity is sufficient to measure small ion concentrations in the presence of high neutral gas densities. During rocket flights the shift in the mass scale between the ion peak and the corresponding neutral peak is a measure for the rocket skin potential.
Observation of second-harmonic generation from a Langmuir-Blodgett monolayer of a merocyanine dye (1985)

Second-harmonic generation (SHG) from a merocyanine dye Langmuir-Blodgett monolayer is reported. Values for the second-order molecular polarisability β and its average orientation within the layer are deduced. Extinction of the SHG is observed for symmetrical bilayers. Protonation of a dye monolayer is seen to suppress SHG.
Chemical synthesis of RNA using fast oligonucleotide deprotection chemistry (1992)

The exocyclic amine protecting groups in oligonucleotide synthesis which require 8-16 hours at 55 degrees C for deprotection in ammonia have been replaced with more labile base protecting groups (dimethylformamidine for adenine and guanine and isobutyryl for cytosine). Using these fast oligonucleotide deprotecting groups which require 2-3 hours at 55 degrees C for complete deprotection, a new set of cyanoethyl phosphoramidite ribonucleoside monomers and supports has been developed. Ribozymes and substrate RNAs which were synthesized with these phosphoramidites were assayed and were found to have full catalytic (biological) activity.
Use of peroxidase-labelled antigen for the detection of antibodies to borrelia burgdorferi in human and animal sera (1991)

We have developed a modified ELISA for the detection of anti-Borrelia burgdorferi (Bb) antibodies based on a peroxidase enzyme labelled antigen (ELAT). Microtiter plates were coated with antigen of Bb. The immunoglobulins of the serum samples were bound to the antigen and specific antibodies were detected by an enzyme labelled antigen. The test principle facilitates the recognition of specific antibodies in different collectives of human and animal sera. We performed epidemiological studies with the ELAT on 231 sera from mothers in maternity wards (9.5% positive), 219 patient sera sent to the Bb routine diagnostics (15% positive) and 230 sera from forestry workers (21.3% positive). We further investigated sera from red deer from South Lower Saxony which remained 55% Bb-antibody positive; deer were 37% and fallow deer were 29% positive.
A wireless multimedia DS-CDMA network based on adaptive transmission rate/power control (2002)

This paper proposes a method of synchronously controlling transmission rate and power for wireless multimedia code division multiple access (CDMA) systems. In the wireless multimedia system, quality of service (QoS) such as bit error rate (BER), signal-to-noise ratio (SNR) and delay time should be taken into account. The wireless CDMA system can achieve a flexible balance if transmission rate and power are both controlled by using channel traffic measurement. In this paper, the optimal control of transmission rate and power is derived by fractional programming. The numerical result show that the proposed method can achieve balance and satisfy the required quality of different media.
Evaluation of a Rapid PCR Assay for Diagnosis of Meningococcal Meningitis (2003)

We compared the results of Gram staining and culture of cerebrospinal fluid to results obtained with a rapid PCR assay for the diagnosis of meningococcal meningitis in 281 cases of suspected bacterial meningitis. PCR had a sensitivity of 97% compared to a sensitivity of 55% for culture, and the PCR specificity was 99.6%. PCR results were available within 2 h of the start of the assay.
National Surveys Via RDD Telephone Interviewing Versus the Internet: Comparing Sample Representativeness and Response Quality (2009)

In a national field experiment, the same questionnaires were administered simultaneously by RDD telephone interviewing, by the Internet with a probability sample, and by the Internet with a nonprobability sample of people who volunteered to do surveys for money. The probability samples were more representative of the nation than the nonprobability sample in terms of demographics and electoral participation, even after weighting. The nonprobability sample was biased toward being highly engaged in and knowledgeable about the survey's topic (politics). The telephone data manifested more random measurement error, more survey satisficing, and more social desirability response bias than did the Internet data, and the probability Internet sample manifested more random error and satisficing than did the volunteer Internet sample. Practice at completing surveys increased reporting accuracy among the probability Internet sample, and deciding only to do surveys on topics of personal interest enhanced reporting accuracy in the nonprobability Internet sample. Thus, the nonprobability Internet method yielded the most accurate self-reports from the most biased sample, while the probability Internet sample manifested the optimal combination of sample composition accuracy and self-report accuracy. These results suggest that Internet data collection from a probability sample yields more accurate results than do telephone interviewing and Internet data collection from nonprobability samples.
Display of DNA on Nanoparticles for Targeting Antigen Presenting Cells (2017)

Efficient delivery of antigens is of paramount concern in immunotherapies. We aimed to target antigen presenting cells (APCs) by conjugating CpG oligonucleotides to an E2 protein nanoparticle surface (CpG-PEG-E2). Compared to E2 alone, we observed ∼4-fold increase of in vitro APC uptake of both CpG-PEG-E2 and E2 conjugated to non-CpG DNA. Furthermore, compared to E2-alone or E2 functionalized solely with polyethylene glycol (PEG), the CpG-PEG-E2 showed enhanced lymph node retention up to at least 48 h and 2-fold increase in APC uptake in vivo, parameters which are advantageous for vaccine success. This suggests that enhanced APC uptake of nanoparticles mediated by oligonucleotide display may help overcome delivery barriers in vaccine development.
Performance Tuning and Scaling Enterprise Blockchain Applications (2019)

Blockchain scalability can be complicated and costly. As enterprises begin to adopt blockchain technology to solve business problems, there are valid concerns if blockchain applications can support the transactional demands of production systems. In fact, the multiple distributed components and protocols that underlie blockchain applications makes performance optimization a non-trivial task. Blockchain performance optimization and scalability require a methodology to reduce complexity and cost. Furthermore, existing performance results often lack the requirements, load, and infrastructure of a production application. In this paper, we first develop a methodical approach to performance tuning enterprise blockchain applications to increase performance and transaction capacity. The methodology is applied to an enterprise blockchain-based application (leveraging Hyperledger Fabric) for performance tuning and optimization with the goal of bridging the gap between laboratory and production deployed system performance. We then present extensive results and analysis of our performance testing for on-premise and cloud deployments, in which we were able to scale the application from 30 to 3000 TPS without forking the Hyperledger Fabric source code and maintaining a reasonable infrastructure footprint. We also provide blockchain application and platform recommendations for performance improvement.
Articulated object tracking by rendering consistent appearance parts (2009)

We describe a general methodology for tracking 3-dimensional objects in monocular and stereo video that makes use of GPU-accelerated filtering and rendering in combination with machine learning techniques. The method operates on targets consisting of kinematic chains with known geometry. The tracked target is divided into one or more areas of consistent appearance. The appearance of each area is represented by a classifier trained to assign a class-conditional probability to image feature vectors. A search is then performed on the configuration space of the target to find the maximum likelihood configuration. In the search, candidate hypotheses are evaluated by rendering a 3D model of the target object and measuring its consistency with the class probability map. The method is demonstrated for tool tracking on videos from two surgical domains, as well as in a human hand-tracking task.
3D packaging technology overview and mass memory applications (2002)

In response to the need for significant reductions in size and weight of digital electronic systems, several companies have developed packaging technologies that focus on miniaturization of memory functions. This paper describes the four basic three dimensional (3D) memory packaging technologies. Physical descriptions and sample photographs of the options provided. Metrics of packaging are developed to provide potential users a means of determining which technology might be best suited to their application. The basics of how to apply 3D memory products are also discussed. Consideration of design and test decisions on product cost are discussed. Also provided are examples of how 3D memory modules may be used in both processor multichip module (MCM) applications and in mass memory (solid-state recorder) applications.
Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow (1963)

Experiments were performed on isolated cat hearts perfused with Tyrode's solution and intact hearts of open-chest dogs. Cardiac hypoxia resulted in a decrease in coronary vascular resistance and a release of significant amounts of inosine and hypoxanthine from the myocardium. From 3 to 27 times more inosine and hypoxanthine were released from the heart during myocardial hypoxia than were required to double the coronary blood flow when infused as adenosine into the left coronary artery. Based on the assumption that with hypoxia the nucleotide derivatives leave the myocardial cell as adenosine, an hypothesis is proposed for the metabolic regulation of coronary blood flow.
Maximizing the Value of Electronic Prescription Monitoring Programs (2003)

There is general agreement that the “principle of balance” should guide controlled substance policy and regulation in the United States. Although the diversion of controlled substances from medical to nonmedical purposes is a significant public health problem, overly aggressive controlled substance regulation has been shown to have an unintended deterrent effect on appropriate controlled substance use, including pain management with opioid analgesics. The promotion of effective pain management and the reduction of substance abuse are equally important regulatory objectives. Neither regulatory objective need be sacrificed to achieve the other. Rather, the two objectives must be balanced with each other to assure that necessary pain management is encouraged while drug abuse is curtailed. Approximately 75 million people in the United States suffer from severe pain. Fifty million of these suffer chronic pain, and 25 million suffer acute pain from trauma or surgery. Pain is not merely an uncomfortable symptom.
Metal template reactions. XVI. Design and synthesis of primary diamine ligands with additional nitrogen donor atoms (1983)

Five new primary diamines (8), (10), (12), (20) and (22) have been synthesized. These compounds contain additional nitrogen donor atoms suitable for metal chelation. An improved preparation of the triamine (6) is also reported.