gebhart/patrepeval huggingface dataset:
LTCC Multi-layer Coupled Strip-Resonator Filters (2007)

Multi-layer coupled strip-resonators are proposed for the design of miniature filters in LTCC technology. Strong capacitive couplings between the strips at different layers are introduced in such resonators to significantly reduce the resonator size. The full-wave numerical method in Sonnet and equivalent circuit models are used to investigate the characteristics of the proposed multi-layer resonators. Two filter examples using triple-layer coupled stripline resonators and double-layer coupled hairpin resonators are presented to validate the feasibility of filter designs using multi-layer resonators.
Electrical properties of epitaxial silicon films on  -alumina (1967)

Single-crystal films of silicon have been deposited on the (1l02) plane of α-alumina by the pyrolysis of silane. Carrier concentration and mobility have been studied in the films as functions of growth temperature and substrate preparation. The effects of initial and overall growth rate have also been examined. Undoped layers are p-type with carrier concentrations from 1015 to 1017 holes/cm3 depending on growth temperature. Hole mobilities up to 174 cm2 v-1 sec-1 have been obtained. Diodes, MOST's and low-gain bipolar transistors have been formed in the material and minority carrier lifetime in the nanosecond range has been estimated from device characteristics.
Triterpene Acids from the Leaves of<i>Perilla frutescens</i>and Their Anti-inflammatory and Antitumor-promoting Effects (2004)

Nine triterpene acids, viz., six of the ursane type, ursolic acid (1), corosolic acid (2), 3-epicorosolic acid (3), pomolic acid (4), tormentic acid (5) and hyptadienic acid (6), and three of the oleanane type, oleanolic acid (7), augustic acid (8) and 3-epimaslinic acid (9), among which 1 constituted the most predominant triterpene acid, were isolated and identified from ethanol extracts of the leaves of red perilla [Perilla frutescens (L.) Britton var. acuta Kudo] and green perilla [P. frutescens (L.) Britton var. acuta Kudo forma viridis Makino]. These eight compounds, 1, 2, 4-9, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 microg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.09-0.3 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA showed five compounds, 1-3, 5 and 9, with a potent inhibitory effect on EBV-EA induction (91-93% inhibition at 1x10(3) mol ratio/TPA). Furthermore, compound 5 exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.
A self-adaptive blanking circuit for IGBT short-circuit protection based on V <sub>CE</sub> measurement (2015)

In order to determine whether the IGBT short-circuit fault occurs, the collector-emitter voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CE</sub> of an IGBT has been detected in the IGBT gate drivers. The blanking circuit is needed in this kind of protection method to avoid the malfunction of the short-circuit protection during IGBT turn-on transient. However, this blanking circuit should be carefully designed for different types of IGBT modules. In order to make the IGBT short-circuit protection circuit suitable for the tolerance of IGBT modules, a self-adaptive blanking circuit combined with the aforementioned short-circuit protection method based on V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CE</sub> measurement is proposed. The analysis of the proposed circuit is given, and the experimental results are included to prove the effectiveness of the proposed circuit.
Immunohistochemical study of immunoglobulin light chain amyloidosis with antibodies to the immunoglobulin light chain variable region (2006)

To detect immunoglobulin (Ig) light chain amyloidosis (AL amyloidosis) in formalin-fixed, paraffin-embedded tissue sections by immunohistochemistry, polyclonal antibodies were generated against synthetic peptides corresponding to amino acids 1-19 of the Ig lambda light chain V lambda VI subgroup (anti-V lambda VI (1-19)) and the Ig kappa light chain Vkappa I subgroup (anti-Vkappa I (1-19)). Anti-V lambda VI (1-19) antibody reacted with amyloid deposits in 21 of 22 Alambda amyloidosis cases, and anti-Vkappa I (1-19) antibody reacted with amyloid deposits in 10 of 11 Akappa amyloidosis cases. Immunoreactivity varied in intensity by case and within specimens. Surprisingly, amyloid deposits were positive for anti-V kappa I (1-19) staining in one case of Alambda amyloidosis. Analysis of anti-V lambda VI (1-19) and anti-Vkappa I (1-19) antibody reactivity by ELISA showed some cross-reactivity with peptides other than antigen peptides. The antibodies were not reactive in all cases of AL amyloidosis examined but may be useful, together with anti-Ig constant region antibodies, for immunohistochemical diagnosis of AL amyloidosis.
Huiles essentielles et bactéries résistantes aux antibiotiques (2007)

L’objectif de ce travail est de faire un screening de l’activité antimicrobienne de 40 huiles essentielles sur deux souches bactériennes résistantes aux antibiotiques (Staphylococcus aureus et Pseudomonas aeruginosa), souvent responsables de maladies nosocomiales, dans le dessein de créer des formulations d’huiles essentielles pour l’assainissement de l’air en milieu hospitalier. S. aureus est une bactérie à Gram positif responsable d’infections des plaies, de la peau et du sang. P. aeruginosa est une bactérie à Gram négatif qui provoque des infections localisées dans l’urine, le sang, les plaies et l’appareil respiratoire. La méthode de l’aromatogramme a révélé que la croissance de S. aureus est inhibée par la plupart des huiles essentielles testées. En revanche, seulement dix huiles essentielles — Cinnamomum cassia, Cinnamosma fragrans, Eucalyptus citriodora, Eucalyptus dives, Eugenia caryophyllata, Melaleuca quinquinervia, Nepeta cataria, Pelargonium roseum, Salvia officinalis et Satureja montana — ont inhibé le développement de P. aeruginosa avec un diamètre d’inhibition supérieur à 13 mm.
Non-myeloablative conditioning with allogeneic hematopoietic cell transplantation for the treatment of high-risk acute lymphoblastic leukemia (2011)

For patients with high-risk acute lymphoblastic leukemia in first complete remission, non-myeloablative conditioning and allogeneic hematopoietic cell transplantation, with post-grafting imatinib for Philadelphia chromosome-positive disease, can result in favorable long-term survival.
Analysis of selected variables in the under-agarose assay for chemotactic responses of canine neutrophils (1991)

Chemotaxis under agarose was evaluated to establish an assay system and to characterize chemotactic responses of canine neutrophils. A method for the measurement of canine neutrophil chemotaxis was established, with optimal responses obtained with agarose containing 10% pooled canine serum, a concentration of 5 x 10(5) cells/well, zymosan-activated serum (ZAS), or autologous serum or plasma as the chemoattractants, and a 120-minute incubation period. Canine neutrophils responded well to ZAS, heat-inactivated ZAS, autologous serum and plasma, and heat-inactivated pooled serum. Chemotactic activity was proportional to the concentration of serum used as the chemoattractant. Mean (+/- SD) random migration, chemotaxis, chemotactic index, and chemotactic differential of neutrophils from 9 healthy Greyhounds were 1.09 (+/- 0.23), 1.95 (+/- 0.38), 1.82 (+/- 0.31), and 0.86 (+/- 0.32) mm, respectively.
Characterization of Neocortical Principal Cells and Interneurons by Network Interactions and Extracellular Features (2004)

Most neuronal interactions in the cortex occur within local circuits. Because principal cells and GABAergic interneurons contribute differently to cortical operations, their experimental identification and separation is of utmost important. We used 64-site two-dimensional silicon probes for high-density recording of local neurons in layer 5 of the somatosensory and prefrontal cortices of the rat. Multiple-site monitoring of units allowed for the determination of their two-dimensional spatial position in the brain. Of the approximately 60,000 cell pairs recorded, 0.2% showed robust short-term interactions. Units with significant, short-latency (<3 ms) peaks following their action potentials in their cross-correlograms were characterized as putative excitatory (pyramidal) cells. Units with significant suppression of spiking of their partners were regarded as putative GABAergic interneurons. A portion of the putative interneurons was reciprocally connected with pyramidal cells. Neurons physiologically identified as inhibitory and excitatory cells were used as templates for classification of all recorded neurons. Of the several parameters tested, the duration of the unfiltered (1 Hz to 5 kHz) spike provided the most reliable clustering of the population. High-density parallel recordings of neuronal activity, determination of their physical location and their classification into pyramidal and interneuron classes provide the necessary tools for local circuit analysis.
Primitive‐Composite Approach for Structural Data Modeling (1992)

Accurate, efficient data exchange is vital to improving productivity in the architecture‐engineering‐construction industry. Much of the current work in data exchange is focused on the development of data exchange standards. In examining the data models in these standards and other efforts, we have identified a number of problem areas, including overuse of aggregation hierarchies, nonhomogeneous characterization hierarchies, and replacing relationships with subclasses. To support easy exchange of data between engineering computer applications while avoiding the data modeling pitfalls, we have developed the primitive‐composite (P‐C) approach. The P‐C approach provides a methodology for defining the primitive data concepts of a domain as separate objects and for assembling those concepts to form the composite abstractions that engineers customarily use. By relating composite objects from multiple programs to the primitive concepts, the data in those programs can be shared as primitive concepts derived from one program's composite object and reassembled as another program's composite object without having to provide a direct mapping between the two programs. The paper presents a formal definition of the primitive‐composite approach and explores its application in structural engineering.
Anatomically Defined Neuron-Based Rescue of Neurodegenerative Niemann–Pick Type C Disorder (2011)

Niemann-Pick type C disease is a fatal lysosomal storage disorder caused by loss of NPC1 function. The disorder severely affects multiple body systems, particularly the nervous system. To test whether rescue of NPC1 activity in neurons, astrocytes, or other cell types can correct the neurological defects, a Tet-inducible Npc1-YFP transgene was introduced into Npc1(-/-) mice for the cell type-specific rescue of NPC1 loss. NPC1-YFP produced in neurons prevented neuron degeneration, slowed reactive glial activity, and ameliorated the disease. NPC1-YFP produced in astrocytes or in cells of visceral tissue did not. These results suggest that loss of NPC1 activity from neurons is the primary cause of the neuropathology and that rescue of NPC1 function in neurons is sufficient to mitigate the disease. The ability of neurons to survive and function in a cell-autonomous fashion allowed the use of this newly engineered rescue system to further define the brain regions or neuron populations required to ameliorate a neurological symptom. NPC1-YFP produced specifically in cerebellar Purkinje neurons reduced ataxia, increased weight, and prolonged life, but it did not prevent the eventual decline and premature death of Npc1(-/-) mice. Significant increase in lifespan correlated with sustained reduction of inflammation in the thalamus. Neuron rescue of other forebrain areas provided little benefit. Future work targeting increasingly discrete neuronal networks should reveal which CNS areas are critical for survival. This work may have broad implications for understanding the anatomical and cellular basis of neurological signs and symptoms of other neurodegenerative and lysosomal disorders.
Community detection in large-scale social networks (2007)

Recent years have seen that WWW is becoming a flourishing social media which enables individuals to easily share opinions, experiences and expertise at the push of a single button. With the pervasive usage of instant messaging systems and the fundamental shift in the ease of publishing content, social network researchers and graph theory researchers are now concerned with inferring community structures by analyzing the linkage patterns among individuals and web pages. Although the investigation of community structures has motivated many diverse algorithms, most of them are unsuitable for large-scale social networks because of the computational cost. Moreover, in addition to identify the possible community structures, how to define and explain the discovered communities is also significant in many practical scenarios.
Development of an Acid-Washable Tag for the Separation of Enantiomers from Bioresolutions (2009)

A separation tool involving the use of a vinyl ester amino acid as acyl donor in a bioresolution has been developed. The acid-washable acyl group acts as a removable tag, facilitating separation of the secondary alcohol from the bioresolution product mixture. The use of these acyl donors from cheap, commercially available amino acids has been demonstrated in conjunction with the hydrolase enzyme Candida antarctica lipase B in the selective acylation of a variety of secondary alcohols.
Abstract 2612: Anti-Tigit induces T cell mediated anti-tumor immune response and combines with immune checkpoint inhibitors to enhance strong and long term anti-tumor immunity (2017)

Abstract TIGIT (T cell immunoreceptor with Ig and ITIM domains) has been recently described as an inhibitory receptor which blocks CD8 T cell-mediated anti-tumor immune responses. We have generated an anti-mouse TIGIT antibody (313R12) to evaluate drug efficacy and mechanism of action in pre-clinical tumor models. Anti-TIGIT as a single agent promoted an anti-tumor immune response in multiple syngeneic mouse tumor models. Anti-TIGIT enhanced tumor specific T cell responses, particularly of the Th1 type and reduced Th2 type responses and also increased the function of cytotoxic T cells. Furthermore, anti-TIGIT displayed combination activity with immune checkpoint inhibitors anti-PD1 and anti-PDL1 in inhibiting tumor growth, promoting complete tumor rejection and significantly increasing mouse survival in the murine CT26 colon carcinoma model as compared to controls and single agents alone. Mice “cured” with anti-TIGIT/anti-PDL1 or anti-TIGIT/anti-PD1 combination treatments did not form tumors upon subsequent re-challenges with increasing number of CT26 tumor cells, suggesting the existence of immunologic memory. IL2 and tumor-specific IFN-γ production by splenic T cells were increased in mice who responded to combination treatment compared to controls. Additionally, both effector and memory CD8+ T cell frequencies were increased within the total CD8+ T cell population in responding mice. We also demonstrated a systemic increase in tumor-specific CD8 T cells after anti-TIGIT/anti-PDL1 combination treatment compared to controls. Therefore, these results suggest that co-targeting of TIGIT and PD1 or PDL1 may be an effective and durable cancer therapy by increasing T cell-mediated anti-tumor immune responses and promoting long-term immunological memory. Citation Format: Minu K. Srivastava, Rui Yun, Erin Mayes, Janice Yu, Hyun-Bae Jie, Fumiko Axelrod, Ming-Hong Xie, Jorge Monteon, Andrew Lam, May Ji, Yuwang Liu, John Lewicki, Tim Hoey, Austin Gurney, Angie Inkyung Park. Anti-Tigit induces T cell mediated anti-tumor immune response and combines with immune checkpoint inhibitors to enhance strong and long term anti-tumor immunity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2612. doi:10.1158/1538-7445.AM2017-2612
How I treat primary CNS lymphoma (2011)

Primary CNS lymphoma (PCNSL) is a rare malignancy with peculiar clinical and biologic features, aggressive course, and unsatisfactory outcome. It represents a challenge for multidisciplinary clinicians and scientists as therapeutic progress is inhibited by several issues. Molecular and biologic knowledge is incomplete, limiting the identification of new therapeutic targets, and the particular microenvironment of this malignancy, and sanctuary sites where tumor cells grow undisturbed, strongly affects treatment efficacy. Moreover, active treatments are known to be associated with disabling neurotoxicity, posing the dilemma of whether to intensify therapy to improve the cure rate or to de-escalate treatment to avoid sequels. The execution of prospective trials is also difficult because of the rarity of the tumor and the impaired general condition and poor performance status of patients. Thus, level of evidence is low, with consequent uncertainties in therapeutic decisions and lack of consensus on primary endpoints for future trials. Despite this unfavorable background, laboratory and clinical researchers are coordinating efforts to develop new ideas, resulting in the recent publication of studies on PCNSL's biology and molecular mechanisms and of the first international randomized trials. Herein, these important contributions are analyzed to provide recommendations for everyday practice and the rationale for future trials.
Cell surface phenotype of the spontaneous immunoglobulin-secreting cells in peripheral blood from homosexual men with generalized lymphadenopathy or AIDS. (1986)

Activated B cells that spontaneously secrete immunoglobulin are found in homosexual men with AIDS or lymphadenopathy. These cells constitute a very small percentage of peripheral blood lymphocytes (usually less than 1%), making identification of their surface antigens difficult. To identify surface antigens on immunoglobulin-secreting cells, peripheral blood mononuclear cells were first reacted with monoclonal antibody, followed by a fluorescein-conjugated goat antimouse globulin reagent. Secretion of immunoglobulin was then assessed in a reverse hemolytic plaque assay, with a modified Cunningham chamber in which an individual plaque-forming cell could be examined with a fluorescence microscope. All plaque-forming cells were found to be reactive with OKT 10 and 4F2 monoclonal antibodies; there was moderate reactivity with anti-la and B4. The same results were found when normal pokeweed mitogen-stimulated lymphocytes were tested. The surface phenotype of these cells is consistent with that of a preplasma cell.
[(O∧N∧N)PtX] Complexes as a New Class of Light-Emitting Materials for Electrophosphorescent Devices (2005)

The synthesis and photophysical properties of the robust Pt(II) emitters [(O--N--N)PtX] (HO--N--N = 6-(2-hydroxyphenyl)-2,2'-bipyridine and its derivatives; X = Cl, Br, I, or -CC-Ph) are reported. Yellow electroluminescent devices based on these materials display a low turn-on voltage (1 cd m(-2) at 4 V) and a high luminance (37000 cd m(-2)). Complex 2e, [(F(t)Bu2O--N--N)PtCl], has the highest thermal stability and gave the best OLED.
PMMA quantum dots composites fabricated via use of pre-polymerization (2005)

We present a novel method to produce a PMMA-quantum-dot (QD) composite fabricated by pre-polymerization of PMMA and dispersing commercially available colloidal semiconductor QDs. The QDs are stabilized in rapidly formed oligomer matrices, and the complete polymerization of the PMMA-QD composite is achieved by commonly used polymerization. The properties of the PMMA-QD composite are measured and compared with the QDs in colloidal solution. Patterning of the PMMAQD composite by direct write electron beam shows its promising applications in optoelectronics.
Tunable, anomalous Mie scattering using spatial coherence (2015)

We demonstrate that a J0-Bessel-correlated beam that is incident on a homogeneous sphere produces a highly unusual distribution of the scattered field, with the maximum no longer occurring in the forward direction. Such a beam can be easily generated using a spatially incoherent, annular source. Moreover, the direction of maximal scattering can be shifted by changing the spatial coherence length. In this process, the total power that is scattered remains constant. This new tool to control scattering directionality may be used to steer the scattered field away from the forward direction and selectively address detectors situated at different angles.
Tailoring haemostatic treatment to patient requirements – an update on monitoring haemostatic response using thrombelastography (2005)

Currently, there is no single haemostasis laboratory test that has the capacity to accurately illustrate the clinical effects of procoagulant or anticoagulant interventions. Although the time course of thrombin generation in plasma and the endogenous thrombin potential (ETP) may be useful coagulation parameters, clotting involves components other than thrombin (e.g. platelets, fibrinogen). The continuous coagulation profiles of thrombelastography may provide a more accurate reflection of in vivo biology, covering initiation, development and final clot strength during whole blood clot formation. This method has helped to clarify the mechanism of action of whole blood clot formation, demonstrating the differences from clotting in plasma, and the importance of platelets and tissue factor titrations. It has also been used to investigate hypocoagulation (in haemophilia A, rare coagulation disorders, anticoagulant therapy and dilutional coagulopathy), hypercoagulation and the ex vivo testing of haemostatic interventions. Thrombelastography has been shown to reflect the clinical efficacy of activated prothrombin complex concentrate (aPCC) and recombinant activated factor VII (rFVIIa) in patients with haemophilia A with inhibitors and in patients with acquired haemophilia. Overall, tailoring laboratory assays to illustrate and correlate with clinical phenotypes is essential for effective coagulation monitoring. Applying an algorithm of preoperative, perioperative and postoperative tests, including thrombelastography, may enable physicians to achieve this.
Pyridoxal phosphate inhibition of platelet function (1980)

The effect of pyridoxal phosphate (PLP) on human platelet function in vitro was studied. PLP inhibited adenosine diphosphate (ADP)-induced shape change, aggregation, and the potentiation by ADP of arachidonic acid-induced aggregation. This inhibition could easily be reversed by increasing concentrations of ADP or by removing PLP. The addition of sodium borohydride to PLP-treated platelets produced an irreversible inhibition of ADP aggregation. Thus it is possible that PLP inhibited ADP-induced platelet function by forming a Schiff base with platelet-surface amino groups. PLP also produced a partial inhibition of platelet aggregation to epinephrine, arachidonic acid, A23187, and a dose-dependent inhibition of [14C]serotonin release to epinephrine and arachidonic acid. PLP did not inhibit [14C]serotonin release to A23187, nor did it suppress arachidonic acid-induced malondialdehyde production. The conclusion is drawn that the partial inhibition by PLP of platelet aggregation observed to epinephrine, arachidonic acid, and A23187 resulted from PLP's inhibition of the effect of released ADP.