gebhart/patrepeval huggingface dataset:
Non-steroidal anti-inflammatory drugs and elderly patients (1995)

Aches and pains are a feature of growing old, but managing these symptoms in elderly people can pose problems. Patients have often used paracetamol and aspirin, which are available over the counter without prescription, before consultation. Opiates cause constipation and non-steroidal anti-inflammatory drugs cause ulcers. Although these associations are well known, 20 million prescriptions for non-steroidal anti-inflammatory drugs (many for elderly people) were dispensed in 1993 in Britain, at a cost of over pounds sterling180m.1

Several factors affect the relative risk of adverse gastrointestinal effects during treatment with non-steroidal anti-inflammatory drugs. These include the age of the patient2 3 4 5 6 7 8; their medical history3 4 6 7; the drug used and its dosage4 9; its route of administration10 and the duration of treatment3 4 8; the concomitant use of more than one such drug4; and other independent risk factors, particularly alcohol use, anti-coagulant treatment, corticosteroid treatment, and smoking.4

The risk of upper gastrointestinal bleeding and ulceration with non-steroidal anti-inflammatory drugs clearly increases with age: Laporte et al calculated an estimated annual incidence of upper gastrointestinal bleeding of 210 per million people over 60 compared with 35 per million for people under 60.7 This effect of …
Interactive Rendering of Translucent Objects<sup>†</sup> (2003)

Abstract This paper presents a rendering method for translucent objects, in which viewpoint and illumination can be modified at interactive rates. In a preprocessing step, the impulse response to incoming light impinging at each surface point is computed and stored in two different ways: The local effect on close‐by surface points is modeled as a per‐texel filter kernel that is applied to a texture map representing the incident illumination. The global response (i.e. light shining through the object) is stored as vertex‐to‐vertex throughput factors for the triangle mesh of the object. During rendering, the illumination map for the object is computed according to the current lighting situation and then filtered by the precomputed kernels. The illumination map is also used to derive the incident illumination on the vertices which is distributed via the vertex‐to‐vertex throughput factors to the other vertices. The final image is obtained by combining the local and global response. We demonstrate the performance of our method for several models. ACM CSS: I.3.7 Computer Graphics— Three‐Dimensional Graphics and Realism Color Radiosity
Regulation of the Pro-B-Cell-Specific Enhancer of the <i>Id1</i> Gene Involves the C/EBP Family of Proteins (1997)

The Id1 protein acts as a negative regulator in early-B-cell differentiation by antagonizing the function of the basic helix-loop-helix transcription factors. Expression of the Id1 gene during B-cell development is governed at the transcriptional level primarily by a pro-B-cell-specific enhancer (PBE) located 3 kb downstream of the gene. We report here the identification of CAAT/enhancer binding protein beta (C/EBPbeta) as a component of the two major PBE-binding complexes (PBEC1 and PBEC2) found in pro-B cells by gel mobility shift assays. Formation of the PBECs is abolished when a classic C/EBP binding site is used as a competitor, and binding complexes similar to the PBECs are formed when the classic C/EBP site is used as a probe. We show that CHOP, a negative regulator of C/EBPs, specifically inhibits PBE binding in vitro and its enhancer activity in vivo. In pro-B cells, C/EBPbeta binds to the PBE site not as apparent homodimers but possibly in association with at least one other polypeptide, which might determine the pro-B-cell-specific expression of the Id1 gene. Although isoforms of C/EBPbeta are expressed in various B cells, they bind to DNA only in LyD9 and Ba/F3 pro-B cells. We show that CHOP is expressed in 70Z/3 and WEHI-231 cells. We also demonstrate that CHOP is associated with C/EBPbeta in WEHI-231 cells, which may provide an additional mechanism to control the function of C/EBPbeta and the expression of the Id1 gene.
Virtual face implant for visual character variations (2011)

One of the main goals in populating the virtual environments (VEs) with human body models is to increase the visual realism of the simulation. Population created with a template model cloning technique is perceived by the viewer as a synthetic crowd. To increase the degree of the visual realism, mainly the characters are generated with various body sizes and solid skin colors. In the case of avatars, a geometric model is customized according to the features of the real counterpart. In this paper we represent a simple and efficient method to improve the visual variance of the virtual characters by implanting a low resolution on any portrait face image. The effect of this model customization process is improved by adapting the whole body skin color with the average color tone calculated over the input face image.
Membrane Attack Complex and Membrane Cofactor Protein Are Related to Tubulointerstitial Inflammation in Various Human Glomerulopathies (1997)

Immunohistochemical analysis of the membrane attack complex (MAC) and the membrane cofactor protein (MCP) was performed on the tubuli and cortical vessels of 46 kidney biopsies with various types of human glomerulopathies. Irrespective of the type of glomerulopathy, significant correlations between tubular MAC and interstitial lymphomonocyte infiltration (p < 0.001) and interstitial volume (p < 0.02) were found. Tubular MCP was significantly overexpressed at the site of MAC deposition (p < 0.002). There was no correlation between the vascular MAC and MCP and tubulointerstitial lesions. Since tubular MAC is deposited in inflamed areas of tubulointerstitium, we propose that MAC might contribute to the development of tubulointerstitial inflammatory processes in human glomerulopathies. MCP as a regulatory factor in the tubulointerstitium might abrogate further tissue damage and cell-stimulatory effects of the MAC.
Address Space Layout Permutation (ASLP): Towards Fine-Grained Randomization of Commodity Software (2006)

Address space randomization is an emerging and promising method for stopping a broad range of memory corruption attacks. By randomly shifting critical memory regions at process initialization time, address space randomization converts an otherwise successful malicious attack into a benign process crash. However, existing approaches either introduce insufficient randomness, or require source code modification. While insufficient randomness allows successful brute-force attacks, as shown in recent studies, the required source code modification prevents this effective method from being used for commodity software, which is the major source of exploited vulnerabilities on the Internet. We propose Address Space Layout Permutation (ASLP) that introduces high degree of randomness (or high entropy) with minimal performance overhead. Essential to ASLP is a novel binary rewriting tool that can place the static code and data segments of a compiled executable to a randomly specified location and performs fine-grained permutation of procedure bodies in the code segment as well as static data objects in the data segment. We have also modified the Linux operating system kernel to permute stack, heap, and memory mapped regions. Together, ASLP completely permutes memory regions in an application. Our security and performance evaluation shows minimal performance overhead with orders of magnitude improvement in randomness (e.g., up to 29 bits of randomness on a 32-bit architecture).
Isolation of rosemary oil: Comparison between hydrodistillation and supercritical CO<sub>2</sub> extraction (1992)

Abstract Rosemary leaf oil was isolated by a supercritical fluid extraction (SFE) procedure coupled to a fractional separation following the extraction stage. The oil produced was compared with rosemary oil isolated by hydrodistillation. Chemical analysis revealed that, although roughly the same compounds were extracted, the two oils possessed a widely different percentage composition. Qualitative aroma testing showed that the oil obtained by SFE using CO 2 showed a fragrance that better resembled that of the rosemary leaves used for the isolation of the oil.
A high-resolution DLL-based digital-to-time converter for DDS applications (2003)

A Digital-to-Time Converter (DTC) based on a Delay-Locked Loop (DLL) for phase interpolation in Direct Digital Synthesis (DDS) applications is described. The conversion is made in two steps using digitally controllable delay cells with configurable shunt-capacitors load. The circuit is able to interpolate a 120 MHz clock, generating a delay proportional to an 8-bit digital control word with 32 ps resolution. The DDS system clock frequency is thus virtually enhanced up to about 30 GHz, achieving a strong reduction of the spurious component level. The 256 level interpolation is achieved using only 35 delay elements (excluding dummy cells).
<title>Three-dimensional display of human fetus image by holographic stereogram</title> (1993)

Three-dimensional image display technique is becoming very important in the field of diagnosis of human fetus by ultrasound B-mode image. We apply the technique of holographic stereogram (HS) to the ultrasound B-mode human fetus images and display a 3-D image which is the real stereoscopic image. In this case each sectional diagram of the human body is measured by the ultrasound B-mode method and the human fetus image is extracted and then a 3-D surface image is reconstructed with the digital image processing. Then the 3-D image is projected to a plane and films which are composed of the various viewpoints are taken. Next, HS is constructed using these films. Then we make clear the condition of making HS. The rainbow hologram is made using the HS as the master hologram and we consider the characteristics of the reconstructed image. Also, the special image reconstructing lamp house is developed for medical application, and we discuss the possibility of this method for the medical diagnosis.
Design of the Logistics Information Management System Based on the B/S Frame (2007)

This article discusses the design of the logistics information management system based on the B/S frame,and it especially analyzes the characteristics of the function modules of this system and the key techniques required.This system can be used for an enterprise's daily logistic management and boost efficiency.
Demonstration of a New On-Line Analyzer for the Measurement of Vaporized Toxic Metal Compounds in a Fluidized Bed Combustor (2002)

In this work we have demonstrated the applicability of a new on-line analyzer to the measurement of vaporized toxic metals, cadmium, and lead, at severe process conditions. The demonstrations were carried out in a bench-scale bubbling fluidized bed combustor during cocombustion tests of biomass and waste fuels. A continuous flow of sample gas is extracted into the analyzer, where it is mixed into the hot plasma jet resulting in substantial atomization of vapor phase and aerosol toxic metal compounds. Atom concentration is measured by atomic absorption spectroscopy with the aid of Zeeman background correction, and finally, the metal concentration in the sample gas is calculated. Analysis is made directly from a hot, wet, and particulate-laden sample gas. A part of the measurements were made at the outlet of the hot cyclone at the temperature of approximately 550 °C, and another part was made directly from the combustion chamber, where temperature was 880 °C. In both cases the measurements were successful and produced new data of cadmium and lead concentrations in hot flue gases. The results were compared with other analysis results, and a rather good agreement was obtained.
Organic Surfactant-Controlled Composition of the Surfaces of CdSe Quantum Dots (2010)

The ratio of Cd to Se (Cd/Se) within colloidal CdSe quantum dots (QDs) synthesized with 90% trioctylphosphine oxide (TOPO) as the coordinating solvent increases from 1.2:1 for QDs with radius R ≥ 3.3 nm to 6.5:1 for R = 1.9 nm, as measured by inductively coupled plasma atomic emission spectroscopy (ICP-AES). The highest value of Cd/Se reported previously for CdSe QDs was 1.8:1. The dependence of Cd/Se on R fits a geometric model that describes the QDs as CdSe cores with Cd/Se = 1:1 encapsulated by a shell of Cd−organic complexes. Use of 99% TOPO as the coordinating solvent produces QDs with Cd/Se ≈ 1:1 for all values of R, and use of 99% TOPO “doped” with n-octylphosphonic acid (OPA), an impurity in 90% TOPO, produces QDs with values of Cd/Se up to 1.5:1. These results imply that Cd enrichment of the QDs is driven by tight-binding Cd2+−alkylphosphonate complexes that stabilize the interface between the polar CdSe core and the organic medium.
The Effect of Race/Ethnicity and Desirable Social Characteristics on Physicians' Decisions to Prescribe Opioid Analgesics (2003)

Patient race/ethnicity did not influence physicians' predispositions to treatment plans in clinical vignettes. Even knowing that the patient had a high-prestige occupation and a primary care provider only minimally increased prescribing of opioid analgesics for conditions with few objective findings.
Probing the role of glutamic acid 144 in the EcoRI endonuclease using aspartic acid and glutamine replacements. (1990)

The x-ray structure of the EcoRI endonuclease-DNA complex (3) suggests that hydrogen bonds between amino acids, glutamic acid 144, arginine 145, and arginine 200, and major groove base moieties are the molecular determinants of specificity. We have investigated residue 144 using aspartate and glutamine substitutions introduced by site-directed mutagenesis. Substitution with glutamine results in a null phenotype (at least a 2000-fold reduction in activity). On the other hand, the aspartic acid mutant (ED144) retained in vivo activity. Substrate binding and catalytic studies were done with purified ED144 enzyme. The affinity of the ED144 enzyme for the canonical sequence 5'-GAATTC-3' is about 340-fold less than the wild-type (WT) enzyme, while its affinity for nonspecific DNA is about 50 times greater. The ED144 enzyme cleaves one strand in the EcoRI site in plasmid pBR322 with a kcat/Km similar to WT. In contrast to the WT enzyme, the ED144 enzyme dissociates after the first strand cleavage. Partitioning between cleavage and dissociation at the first and second cleavage steps for the ED144 enzyme is extremely salt-sensitive. The altered partitioning results largely from a destabilization of the enzyme-DNA complex, particularly the enzyme-nicked DNA complex, with only small changes in the respective cleavage rates. The hydrogen bonds of Glu-144 are critical, they appear to act cooperatively with other specificity contacts to stabilize the enzyme-DNA complex.
New pepstatin analogs: synthesis and pepsin inhibition (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew pepstatin analogs: synthesis and pepsin inhibitionRose M. McConnell, Donna Frizzell, Amanda Camp, Anissa Evans, Wanda Jones, and Cathy CagleCite this: J. Med. Chem. 1991, 34, 7, 2298–2300Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/jm00111a054https://doi.org/10.1021/jm00111a054research-articleACS PublicationsRequest reuse permissionsArticle Views259Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ligand Specificity in the CRAL-TRIO Protein Family (2003)

Intracellular trafficking of hydrophobic ligands is often mediated by specific binding proteins. The CRAL-TRIO motif is common to several lipid binding proteins including the cellular retinaldehyde binding protein (CRALBP), the alpha-tocopherol transfer protein (alpha-TTP), yeast phosphatidylinositol transfer protein (Sec14p), and supernatant protein factor (SPF). To examine the ligand specificity of these proteins, we measured their affinity toward a variety of hydrophobic ligands using a competitive [(3)H]-RRR-alpha-tocopherol binding assay. Alpha-TTP preferentially bound RRR-alpha-tocopherol over all other tocols assayed, exhibiting a K(d) of 25 nM. Binding affinities of other tocols for alphaTTP closely paralleled their ability to inhibit in vitro intermembrane transfer and their potency in biological assays. All other homologous proteins studied bound alpha-tocopherol but with pronouncedly weaker (> 10-fold) affinities than alpha-TTP. Sec14p demonstrated a K(d) of 373 nM for alpha-tocopherol, similar to that for its native ligand, phosphatidylinositol (381 nM). Human SPF had the highest affinity for phosphatidylinositol (216 nM) and gamma-tocopherol (268 nM) and significantly weaker affinity for alpha-tocopherol (K(d) 615 nM). SPF bound [(3)H]-squalene more weakly (879 nM) than the other ligands. Our data suggest that of all known CRAL-TRIO proteins, only alphaTTP is likely to serve as the physiological mediator of alpha-tocopherol's biological activity. Further, ligand promiscuity observed within this family suggests that caution should be exercised when suggesting protein function(s) from measurements utilizing a single ligand.
Władysław Abraham (Professor an der Universität Lemberg), Pontificale biskupów krakowskich z XII wieku (Ein Pontificaled er Krakauer Bischöfe aus dem XII. Jahrhundert). Tadeusz Silnicki (Privatdozent an der Universität Lemberg), Organizacya archidyakonatu w Polsce (Die Organisation des Archidiakonats in Polen). Acta Officii consistorialis Leopoliensis antiquissima edidit Guilelmus Rolny (1928)

Article Władysław Abraham (Professor an der Universität Lemberg), Pontificale biskupów krakowskich z XII wieku (Ein Pontificaled er Krakauer Bischöfe aus dem XII. Jahrhundert). Tadeusz Silnicki (Privatdozent an der Universität Lemberg), Organizacya archidyakonatu w Polsce (Die Organisation des Archidiakonats in Polen). Acta Officii consistorialis Leopoliensis antiquissima edidit Guilelmus Rolny was published on August 1, 1928 in the journal Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Kanonistische Abteilung (volume 17, issue 1).
Adolescent and adult acute lymphoblastic leukemia: prognostic features and outcome of therapy. A study of 293 patients (1982)

The case histories of 293 adolescent and adult patients with acute lymphoblastic leukemia (ALL) first seen and treated between 1969 and 1979 are reviewed. A complete remission (CR) was achieved in 79% of cases. Male sex, advanced age (greater than or equal to 30 yr old), and early CNS involvement were the major determinants of remission failure. Median duration of first CR was 16 mo, with 23 patients (actuarial proportion 25%) alive and relapse-free at 5 yr. The major determinant of first CR length was white blood cell (WBC) count (best cut-off value at 35 X 10(9)/liter). First CR length was also negatively affected by early CNS involvement, morphological FAB L3 subtype, and B-cell (Smlg+) leukemia, but these features were significantly associated with a high WBC count. First CR length in patients 11–15 yr old did not differ significantly from that of patients 16–59 yr old. The negative prognostic value of T-cell (E+) leukemia was not confirmed in this adult series. CNS prophylaxis provided an effective protection against CNS relapse. Maintenance chemotherapy was apparently more effective when 4 or more than 4 drugs were employed. “Low risk” patients (WBC count less than 35 X 10(9)/liter still relapsed rather frequently (32% at 1 yr, 49% at 2 yr), with 33% of them alive and relapse-free at 5 yr. “High risk” patients (WBC count greater than or equal to 35 X 10(9)/liter +/- early CNS involvement +/- morphological L3 subtype +/- B-cell leukemia) relapsed very quickly (50% at 6 mo. 70% at 1 yr), with only 6% of them relapse-free at 5 yr.
Design and Analysis of CMOS LNAs with Transformer Feedback for Wideband Input Matching and Noise Cancellation (2017)

This paper presents a new transformer-feedback technique for RF and millimeter-wave (mmW) low-noise amplifiers (LNAs). The working principle of conventional LNAs using transformers is analyzed to show their underlying performance trade-off between input matching and noise figure (NF). To mitigate this issue, a new feedback technique is developed by constructing a drain-to-gate feedback path around the input transistor with a transformer and then further demonstrated by two LNA prototypes. In the first LNA aiming for software-defined radio (SDR) applications, the proposed technique not only achieves wideband input matching but also enables noise cancellation through an auxiliary out-of-phase forward path. Fabricated in 0.13-μm CMOS, the LNA measures voltage gain >14 dB, minimum NF of 1.8 dB, IIP3 of 1.8-3.8 dBm, and S11<; -10 dB over a frequency range of 1.2-6.6 GHz, while consuming 13.2 mW. The second LNA implemented in 65-nm CMOS operates from 55 to 65 GHz and achieves a 16.4-dB conversion gain and a 6.8-dB minimum NF, with power dissipation of 33.6 mW. Particularly, the measured S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> remains below -10 dB from 49.5 to 67 GHz.
Film Bulk Acoustic-Wave Resonator Based Relative Humidity Sensor Using ZnO Films (2010)

This article described relative humidity (RH) sensing using a ZnO-based film bulk acoustic-wave resonator (FBAR). The resonant frequency of the FBAR decreased in a two-stage manner as the RH increased. For low RH, a frequency downshift of 2.2 kHz per 1% RH change was observed. This effect was attributed to water molecules replacing the adsorbed oxygen on the ZnO surface, thus increasing the density of the film. For high RH, a frequency downshift of 8.5 kHz per 1% RH change was obtained, which was due to the mass loading effect of the water layers formed on the ZnO surface.