gebhart/patrepeval huggingface dataset:
Characterization of Functional Domains of the SMN Proteinin Vivo (2001)

The Survival of Motor Neurons (SMN) is the disease gene of spinal muscular atrophy. We have previously established a genetic system based on the chicken pre-B cell line DT40, in which expression of SMN protein is regulated by tetracycline, to study the function of SMN in vivo. Depletion of SMN protein is lethal to these cells. Here we tested the functionality of mutant SMN proteins by determining their capacity to rescue the cells after depletion of wild-type SMN. Surprisingly, all of the spinal muscular atrophy-associated missense mutations tested were able to support cell viability and proliferation. Deletion of the amino acids encoded by exon 7 of the SMN gene resulted in a partial loss of function. A mutant SMN protein lacking both the tyrosine/glycine repeat (in exon 6) and exon 7 failed to sustain viability, indicating that the C terminus of the protein is critical for SMN activity. Interestingly, the Tudor domain of SMN, encoded by exon 3, does not appear to be essential for SMN function since a mutant deleted of this domain restored cell viability. Unexpectedly, a chicken SMN mutant (DeltaN39) lacking the N-terminal 39 amino acids that encompass the Gemin2-binding domain also rescued the lethal phenotype. Moreover, the level of Gemin2 in DeltaN39-rescued cells was significantly reduced, indicating that Gemin2 is not required for DeltaN39 to perform the essential function of SMN in DT40 cells. These findings suggest that SMN may perform a novel function in DT40 cells.
Regenerative braking control strategy for fuel cell hybrid vehicles using fuzzy logic (2008)

One of the advantages of using electric vehicles (EVs) and hybrid electric vehicles (HEVs) is recovering energy through vehiclepsilas braking regeneration. In this paper, a regenerative braking control strategy for a fuel cell hybrid vehicular power system has been presented based on fuzzy logic. Fuel cell output power is determined according to the driving load requirement and the battery SOC, using fuzzy control concept. Simulation results show that the proposed control strategies can maintain the SOC of battery around target range and restore the braking regenerated energy during driving cycle test.
Continuum source atomic absorption spectrometry with high resolution and wavelength modulation (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTContinuum source atomic absorption spectrometry with high resolution and wavelength modulationAndrew T. Zander, Thomas C. O'Haver, and Peter N. KeliherCite this: Anal. Chem. 1976, 48, 8, 1166–1175Publication Date (Print):July 1, 1976Publication History Published online1 May 2002Published inissue 1 July 1976https://pubs.acs.org/doi/10.1021/ac50002a026https://doi.org/10.1021/ac50002a026research-articleACS PublicationsRequest reuse permissionsArticle Views205Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Overview of IBM system/390 parallel sysplex-a commercial parallel processing system (2002)

Scalability has never been more a part of System/390 than with Parallel Sysplex. The Parallel Sysplex environment permits a mainframe or Parallel Enterprise Server to grow from a single system to a configuration of 32 systems (initially), and appear as a single image to the end user and applications. The IBM S/390 Parallel Sysplex provides capacity for today's largest commercial workloads by enabling a workload to be spread transparently across a collection of S/390 systems with shared access to data. By way of its parallel architecture and MVS operating system support, the S/390 Parallel Sysplex offers near-linear scalability and continuous availability for customers' mission-critical applications. S/390 Parallel Sysplex optimizes responsiveness and reliability by distributing workloads across all of the processors in the Sysplex. Should one or more processors fail, the workload is redistributed across the remaining processors. Because all of the processors have access to all of the data, the Parallel Sysplex provides a computing environment with near-continuous availability.
IPv6-only and Dual Stack Hosts on the Same Network with DNS64 (2011)

Some networks are expected to support IPv4-only, dual-stack, and
IPv6-only hosts at the same time. Such networks also want to IPv6/
IPv4 translation for the IPv6-only host so it can access servers on
the IPv4 Internet. On such a network, the synthesized AAAA responses
from a DNS64 can cause traffic to be translated. This document
describes two solutions to avoid that translation: modifying default
address selection on the host, and using DHCP to configure different
DNS recursive resolvers.
Data Augmentation for EEG-Based Emotion Recognition Using Generative Adversarial Networks (2021)

One of the greatest limitations in the field of EEG-based emotion recognition is the lack of training samples, which makes it difficult to establish effective models for emotion recognition. Inspired by the excellent achievements of generative models in image processing, we propose a data augmentation model named VAE-D2GAN for EEG-based emotion recognition using a generative adversarial network. EEG features representing different emotions are extracted as topological maps of differential entropy (DE) under five classical frequency bands. The proposed model is designed to learn the distributions of these features for real EEG signals and generate artificial samples for training. The variational auto-encoder (VAE) architecture can learn the spatial distribution of the actual data through a latent vector, and is introduced into the dual discriminator GAN to improve the diversity of the generated artificial samples. To evaluate the performance of this model, we conduct a systematic test on two public emotion EEG datasets, the SEED and the SEED-IV. The obtained recognition accuracy of the method using data augmentation shows as 92.5 and 82.3%, respectively, on the SEED and SEED-IV datasets, which is 1.5 and 3.5% higher than that of methods without using data augmentation. The experimental results show that the artificial samples generated by our model can effectively enhance the performance of the EEG-based emotion recognition.
Facial follicular porphyrin fluorescence: correlation with age and density of <i>Propionibacterium acnes</i> (1980)

The incidence and distribution of facial follicular porphyrin fluorescence was studied in a large group of subjects ranging in age from 1 to 90 years. Fluorescence appears first on the nose and chin, increases in incidence through adulthood and declines after the age of 50 possibly rflecting the ras population and confirmed that coproporphyrin III is proed in vivo.
Resonant tunneling transistor with quantum well base and high-energy injection: A new negative differential resistance device (1985)

We propose a new negative conductance device consisting of a heterojunction bipolar transistor with a quantum well and a symmetric double barrier or a superlattice in the base region. The key difference compared to previously studied structures is that resonant tunneling is achieved by high-energy minority carrier injection into the quantum state rather than by application of an electric field. Thus this novel geometry maintains the crucial, structural symmetry of the double barrier, allowing unity transmission at all resonance peaks and higher peak-to-valley ratios and currents compared to conventional resonant tunneling structures. Both tunneling and ballistic injection in the base are considered. These new functional devices have significant potential for a variety of signal processing and multiple-valued logic applications and for the study of the physics of transport in superlattices.
Preimplantation Genetic Diagnosis: Prenatal Testing for Embryos Finally Achieving Its Potential (2014)

Preimplantation genetic diagnosis was developed nearly a quarter-century ago as an alternative form of prenatal diagnosis that is carried out on embryos. Initially offered for diagnosis in couples at-risk for single gene genetic disorders, such as cystic fibrosis, spinal muscular atrophy and Huntington disease, preimplantation genetic diagnosis (PGD) has most frequently been employed in assisted reproduction for detection of chromosome aneuploidy from advancing maternal age or structural chromosome rearrangements. Major improvements have been seen in PGD analysis with movement away from older, less effective technologies, such as fluorescence in situ hybridization (FISH), to newer molecular tools, such as DNA microarrays and next generation sequencing. Improved results have also started to be seen with decreasing use of Day 3 blastomere biopsy in favor of polar body or Day 5 trophectoderm biopsy. Discussions regarding the scientific, ethical, legal and social issues surrounding the use of sequence data from embryo biopsy have begun and must continue to avoid concern regarding eugenic or inappropriate use of this technology.
Humic Acid Reduction by <i>Propionibacterium freudenreichii</i> and Other Fermenting Bacteria (1998)

Iron-reducing bacteria have been reported to reduce humic acids and low-molecular-weight quinones with electrons from acetate or hydrogen oxidation. Due to the rapid chemical reaction of amorphous ferric iron with the reduced reaction products, humic acids and low-molecular-weight redox mediators may play an important role in biological iron reduction. Since many anaerobic bacteria that are not able to reduce amorphous ferric iron directly are known to transfer electrons to other external acceptors, such as ferricyanide, 2,6-anthraquinone disulfonate (AQDS), or molecular oxygen, we tested several physiologically different species of fermenting bacteria to determine their abilities to reduce humic acids. Propionibacterium freudenreichii, Lactococcus lactis, and Enterococcus cecorum all shifted their fermentation patterns towards more oxidized products when humic acids were present; P. freudenreichii even oxidized propionate to acetate under these conditions. When amorphous ferric iron was added to reoxidize the electron acceptor, humic acids were found to be equally effective when they were added in substoichiometric amounts. These findings indicate that in addition to iron-reducing bacteria, fermenting bacteria are also capable of channeling electrons from anaerobic oxidations via humic acids towards iron reduction. This information needs to be considered in future studies of electron flow in soils and sediments.
Ammino Compounds of Triphenyllead Chloride (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmmino Compounds of Triphenyllead ChlorideLaurence S. Foster, Irving J. Gruntfest, and Linton A. FluckCite this: J. Am. Chem. Soc. 1939, 61, 7, 1687–1690Publication Date (Print):July 6, 1939Publication History Published online1 May 2002Published inissue 6 July 1939https://pubs.acs.org/doi/10.1021/ja01876a015https://doi.org/10.1021/ja01876a015research-articleACS PublicationsRequest reuse permissionsArticle Views20Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pushing the Wireline Operation to New Frontiers (2008)

Abstract This paper presents a case study of field trials completed by Saudi Aramco to evaluate use of the Wireline Engineering Company's Roller Bogie™ tool to improve wireline (both Slick and Electric Line) intervention in highly deviated cased-hole wells. Conventional wireline intervention tool operations are normally limited to a maximum of 65° inclination due to frictional resistance between the wireline toolstring components and well tubulars. The Roller Bogie™ tool was used to overcome well inclination limitations and complete necessary wireline interventions without the utilization of costly and complex coiled tubing or wireline tractor operations. Conceptually, the Roller Bogie™ tool drastically reduces frictional contact between the wireline toolstring and the wellbore tubulars by lifting the entire wireline assembly off the well tubulars on low-friction rollers. Moreover, the Roller Bogies™ uses a self-orienting body profile to ensure that the rollers are always located on the low side of the tubing and also have integral swivels that allow the rollers to be oriented independently to the rest of the toolstring. The use of this tool in Saudi Aramco wells has enabled conventional wireline operations to be conducted at well deviations in excess of 82°. The Roller Bogie™ tool was used in tandem with a cement bond log (CBL) tool in an offshore highly deviated (maximum of 87°) cased hole oil well at a depth of 9,154 ft (2,790 m). This CBL log was recorded successfully at a maximum of 82° of inclination and to a depth of 8,406 ft (2,526 m) without any significant wear out or damage to the Roller Bogie™ tool or attached wireline assemblies. After the success of the trial test operation and the resultant cost avoidance of the coil tubing or wireline tractor utilization, additional operations were completed, such as bridge plug installation, perforating and ceramic disc rupturing.
Resource allocation for elastic traffic: architecture and mechanisms (2002)

For the last decade, QoS support for the Internet has focused on real-time applications such as audio and video. However, today's Internet is dominated by elastic traffic flows (such as Web traffic) that are more tolerant of delay and jitter. Such traffic flows tend to be short-lived and the end-to-end reservation approach for resource allocation does not work well for them. Some form of flow aggregation is required to do resource allocation in a scalable manner. In this paper, we present user-share differentiation (USD), an architecture for providing long-term, scalable, resource allocation for elastic traffic. The USD scheme has the advantages of per-customer traffic isolation, flexible service models, and scalability. We also summarize simulation results (presented in Basu et al. (1998), in detail) that show the effectiveness of the USD scheme.
72. Furano-compounds. Part IX. The synthesis of kellin and related compounds (1949)

J. R. Clarke and A. Robertson, J. Chem. Soc., 1949, 302 DOI: 10.1039/JR9490000302
Pathology Reporting of Neuroendocrine Tumors: Application of the Delphic Consensus Process to the Development of a Minimum Pathology Data Set (2010)

Epithelial neuroendocrine tumors (NETs) have been the subject of much debate regarding their optimal classification. Although multiple systems of nomenclature, grading, and staging have been proposed, none has achieved universal acceptance. To help define the underlying common features of these classification systems and to identify the minimal pathology data that should be reported to ensure consistent clinical management and reproducibility of data from therapeutic trials, a multidisciplinary team of physicians interested in NETs was assembled. At a group meeting, the participants discussed a series of "yes" or "no" questions related to the pathology of NETs and the minimal data to be included in the reports. After discussion, anonymous votes were taken, using the Delphic principle that 80% agreement on a vote of either yes or no would define a consensus. Questions that failed to achieve a consensus were rephrased once or twice and discussed, and additional votes were taken. Of 108 questions, 91 were answerable either yes or no by more than 80% of the participants. There was agreement about the importance of proliferation rate for tumor grading, the landmarks to use for staging, the prognostic factors assessable by routine histology that should be reported, the potential for tumors to progress biologically with metastasis, and the current status of advanced immunohistochemical and molecular testing for treatment-related biomarkers. The lack of utility of a variety of immunohistochemical stains and pathologic findings was also agreed upon. A consensus could not be reached for the remaining 17 questions, which included both minor points related to extent of disease assessment and some major areas such as terminology, routine immunohistochemical staining for general neuroendocrine markers, use of Ki67 staining to assess proliferation, and the relationship of tumor grade to degree of differentiation. On the basis of the results of the Delphic voting, a minimum pathology data set was developed. Although there remains disagreement among experts about the specific classification system that should be used, there is agreement about the fundamental pathology data that should be reported. Examination of the areas of disagreement reveals significant opportunities for collaborative study to resolve unanswered questions.
The status of Bogidiella Balearica Dancau, 1973, a stygobiont amphipod from Mallorca (1987)

&#091;spa&#093; Se presenta la redescripción de Bogidiella balearica Dancau, 1973, un anfípodo estigobionte de las cuevas anquihalinas de Mallorca. Queda demostrado que se trata de una buena especie, clasificable dentro del subgénero Bogidiella s. str., y que se puede diferenciar fácilmente de Bogidiella chappuisi Ruffo, 1952 (con la cual se intentó sinonimizar con anterioridad), perteneciente a otro subgénero, Medigidiella.
Statistical analyses for in vitro cytogenetic assays using chinese hamster ovary cells (1986)

It is a widely held view that objective statistical criteria are needed for the evaluation of genetic toxicity assays. This paper presents statistical methods for the analysis of data from in vitro sister chromatid exchange (SCE) and chromosome aberration tests that use Chinese hamster ovary cells. For SCEs, an extensive study of solvent control results demonstrated that there is a substantial interday component of variability in the data, and that a Poisson sampling model is applicable to data generated via the protocol of Galloway et al [1985]. Consequently, a trend test for evidence of a dose response is proposed for such SCE data. As an illustration of this statistical method, analysis of data previously considered to be negative [Gulati et al, 1985] indicates that di(2-ethyl-hexyl) phthalate induces a weak, but reproducible, SCE dose response in CHO cells. Monte Carlo methods are used to show that the trend test is more sensitive than four other statistical procedures considered for the analysis of Poisson-distributed SCEs. A similar trend test for dose response in proportions is proposed for chromosome aberration data, where the percent of cells with chromosome aberrations is the response of interest. Sensitivity (or power) studies indicate that three doses and a control with 50 cells/dose point is a reasonable design for an in vitro SCE study that uses the Galloway et al protocol. For in vitro chromosome aberrations, however, three doses and a control with 100 cells/dose point appears to produce too insensitive an assay; an increase to 200 cells/dose point in the Galloway et al protocol seems worthy of serious consideration.
Efficient expression of a heterologous gene in plants depends on the nucleotide composition of mRNA’s 5'-region (2016)

The contribution of nucleotide composition of mRNA 5'-region to the efficiency of expression at transcriptional and translational levels was studied in transgenic tobacco plants (Nicotiana tabacum L., cultivar Petit Havana) using a thermostable lichenase reporter gene. Synthetic sequence that contains CG-rich motifs, typical for 5'-region of plant genes, identified in silico, was constructed. Transgenic plant lines of N. tabacum were obtained; they contain thermostable lichenase reporter gene that is under control of the constitutive 35S RNA CaMV promoter and additional regulatory element: synthetic CG-rich sequence, which functions as the 5'-UTR (untranslated region) of the reporter gene mRNA or as 5'-region of the hybrid gene coding sequence, wherein the synthetic sequence is fused with the sequence of the reporter gene in its reading frame. Results of the comparative analysis of mRNA and protein levels in the obtained lines of transgenic plants showed that the synthetic CG-rich sequence significantly increases the level of transcription of the reporter gene and appear to have no negative effect on the efficiency of reporter mRNA translation, which may be due to the peculiarities of its nucleotide composition and structure, namely, due to the presence of motifs that are specific for 5'-regions of plant genes, as well as due to the properties of the secondary structure— the absence of hairpin structures with a high energy of formation. It was experimentally confirmed for the first time that the 5'-region of the genes with a high content of CpG dinucleotides can help to increase the transcription level of genes in plants.
Plastic optical touch panels for large-scale flexible display (2013)

A plastic optical touch panel applicable for large-scale flexible display is demonstrated based on a vertical directional coupling between arrayed channel waveguides and a flexible planar waveguide. When a contact force is applied to the surface, the flexible planar waveguide is bent toward the channel waveguide, and then, the guided mode in the channel waveguide is coupled into the flexible planar waveguide, causing an output power drop. An index-matching liquid is used to fill the gap between the channel and the flexible planar waveguide in order to enhance the transparency of the waveguide touch panel. By applying a force of 1.0 N, the output intensity is decreased by 17 dB, which is sufficiently large for producing a contact signal.
RollCaller: User-friendly indoor navigation system using human-item spatial relation (2014)

Indoor navigation has received much attention in academics and industry in recent years. Previous methods often attempt to locate users with various localization algorithms in combination with an indoor map, so they need expensive infrastructures deployed in advance. In this study, we propose to utilize existing indoor objects attached RFID tags and the reader to navigate the user to the destination, without need of any extra hardware. The key insight is that the personal movement takes an impact on the Doppler frequency shift values collected from the indoor objects when getting close to the tag. Such local human-item spatial relation is leveraged to infer the users position and further navigate user to destination step by step. We implement a prototype navigation system, called RollCaller, and conduct comprehensive experiments to examine its performance.