gebhart/patrepeval huggingface dataset:
A Manhattan fiber distributed data interface architecture (2002)

The Manhattan street network (MSN) is a two-connected regular mesh network, applicable to local area networks, that exhibits an increased throughput performance. The fiber distributed data interface (FDDI) single-loop token ring local area network exhibits high data rate over fiber medium and self-restoring properties. A two-connected regular mesh network topology with FDDI, called M-FDDI, with a node capacity in excess of 250000 is presented. The M-FDDI network exhibits high data rate (100 Mbps or higher) and self-restoration. Control in the M-FDDI is fully distributed, and each node is capable of knowing the status of the other nodes to determine the best route and avoid deadlock conditions. The network is expandable by incorporating standard network expansion practices allowing for other LANs or long haul networks to be connected.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The reaction ensemble method for the computer simulation of chemical and phase equilibria. I. Theory and basic examples (1994)

We present a new efficient Monte Carlo method for the molecular-based computer simulation of chemical systems undergoing any combination of reaction and phase equilibria. The method requires only a knowledge of the species intermolecular potentials and their ideal-gas properties, in addition to specification of the system stoichiometry and thermodynamic constraints. It avoids the calculation of chemical potentials and fugacities, as is similarly the case for the Gibbs ensemble method for phase equilibrium simulations. The method’s simplicity allows it to be easily used for situations involving any number of simultaneous chemical reactions, reactions that do not conserve the total number of molecules, and reactions occurring within or between phases. The basic theory of the method is presented, its relationship to other approaches is discussed, and applications to several simple example systems are illustrated.
Secretion, purification and activity of two recombinant pepper endo‐β‐1,4‐glucanases expressed in the yeast <i>Pichia pastoris</i> (1998)

Two pepper endo-beta-1,4-glucanases, involved in fruit softening (cCel1) and leaf and flower abscission (cCel2), have been expressed in Pichia pastoris. Secretion was obtained by using either the mouse alpha-factor signal (cCel1) or the native signal sequence (cCel2). Times for optimal expression of the two proteins were different and cCel2 appeared very sensitive to proteolytic degradation. A one-step purification protocol yielded cCel2 in a pure form, while an additional chromatography step was necessary to purify cCel1. The two recombinant proteins are highly active and able to degrade carboxymethylcellulose in viscometric assays. Moreover, they have both a molecular mass (54 kDa) and an isoelectric point (7.2 for cCel2 and 8.5 for cCel1) equal to those of the native proteins, thus suggesting that post-translational modifications have properly occurred.
Lung Macrophages Serve as Obligatory Intermediate between Blood Monocytes and Alveolar Macrophages (2007)

Alveolar macrophages are a unique type of mononuclear phagocytes that populate the external surface of the lung cavity. Early studies have suggested that alveolar macrophages originate from tissue-resident, local precursors, whereas others reported their derivation from blood-borne cells. However, the role of circulating monocytes as precursors of alveolar macrophages was never directly tested. In this study, we show through the combined use of conditional cell ablation and adoptive cell transfer that alveolar macrophages originate in vivo from blood monocytes. Interestingly, this process requires an obligate intermediate stage, the differentiation of blood monocytes into parenchymal lung macrophages, which subsequently migrate into the alveolar space. We also provide direct evidence for the ability of both lung and alveolar macrophages to proliferate.
A competent design of 2&#x2236;1 multiplexer and its application in 1-bit full adder cell (2013)

It is a combinational logic circuit, it is used in application in which data must be switched from multiple source to a destination as unidirectional device. it represent the simulation of different 2:1 its comperative analysis on different parameter such as power supply voltage, operating A multiplexer is known as mux. It is a device that helps in selection a number of input signals, frequency temperature and area efficiency and its applications in 1bit full adder cell all the simulation have been followed on cadence tool at 180nm technology at virtuoso.
Collaborative grasp planning with multiple object representations (2011)

Grasp planning based on perceived sensor data of an object can be performed in different ways, depending on the chosen semantic interpretation of the sensed data. For example, if the object can be recognized and a complete 3D model is available, a different planning tool can be selected compared to the situation in which only the raw sensed data, such as a single point cloud, is available. Instead of choosing between these options, we present a framework that combines them, aiming to find consensus on how the object should be grasped by using the information from each object representation according to their confidence levels. We show that this method is robust to common errors in perception, such as incorrect object recognition, while also taking into account potential grasp execution errors due to imperfect robot calibration. We illustrate this method on the PR2 robot by grasping objects common in human environments.
Biological Marker Candidates of Alzheimer's Disease in Blood, Plasma, and Serum (2009)

At the earliest clinical stages of Alzheimer's disease (AD), when first symptoms are mild, making a reliable and accurate diagnosis is difficult. AD related brain pathology and underlying molecular mechanisms precede symptoms. Biological markers can serve as supportive early screening and diagnostic tools as well as indicators of presymptomatic biochemical change. Moreover, biomarkers cover a variety of roles and functions such as disease prediction, indicating disease acuity and progression, and may ensure biological mapping of treatment outcome. Early screening, detection, and diagnosis of AD would permit earlier disease modifying intervention at potentially reversible stages. To date, most established biological markers from both cerebrospinal fluid neurochemistry and structural and functional neuroimaging have not reached widespread clinical application. Crucial remaining problems, such as easy acceptance and application of a test, cost-effectiveness, and noninvasiveness, need to be resolved. The development and validation of precise, reliable, and robust tests and biomarkers in blood, plasma, or serum has therefore been for a long time the ultimate focus of many research groups worldwide. Blood-based testing will most likely be the prerequisite to future sensitive screening of large populations at risk of AD and the baseline in a diagnostic flow approach to AD. The status and emerging perspectives on hypothesis and exploratory-based candidate biomarkers derived from blood, plasma, and serum are reviewed and discussed.
Multistate per-cell magnetoresistive random-access memory written at Curie point (2002)

A multistate per-cell magnetoresistive random-access memory (MRAM) that writes data by a thermally assisted technique and reads data using the angular-dependent magnetoresistance is proposed. A hard magnetic layer or pinned ferromagnetic layer (CoFe-IrMn) is used as the recording layer. The free layer serves as the read layer. Before reading, the free layer's magnetization is set to the initial state. For the N states per-cell MRAM, the magnetization angle of the ith state (i=0 to N-1) between the free layer and recording layer can be set to be acos(1-2*i/(N-1)). For example, in the four-state per-cell MRAM, the magnetization angle can be set to be acos(1), acos(1/3), acos(-1/3), and acos(-1), which represent the four states, respectively. More states can be obtained if the signal-to-noise ratio is sufficient. At near Curie point, a small external field can be used to record the signal. In order to verify the idea, a spin-valve giant-magnetoresistance memory cell was fabricated using e-beam lithography and ultrahigh voltage sputtering. A 25-mA heating current and a small external field are enough to assist the writing process. A four-state per-cell memory is realized by this method.
Binder-Free Manganese Oxide/Carbon Nanomaterials Thin Film Electrode for Supercapacitors (2011)

A ternary thin film electrode was created by coating manganese oxide onto a network composed of single-walled carbon nanotubes and single-walled carbon nanohorns. The electrode exhibited a porous structure, which is a promising architecture for supercapacitors applications. The maximum specific capacitances of 357 F/g for total electrode at 1 A/g were achieved in 0.1 M Na(2)SO(4) aqueous solution.
Organophosphorus Compounds as Schistosomicides (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganophosphorus Compounds as SchistosomicidesLeslie M. Werbel and Paul E. ThompsonCite this: J. Med. Chem. 1967, 10, 1, 32–36Publication Date (Print):January 1, 1967Publication History Published online1 May 2002Published inissue 1 January 1967https://pubs.acs.org/doi/10.1021/jm00313a006https://doi.org/10.1021/jm00313a006research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Review: Deep brain stimulation in Parkinson’s disease (2009)

During the last 15 years deep brain stimulation (DBS) has been established as a highly-effective therapy for advanced Parkinson's disease (PD). Patient selection, stereotactic implantation, postoperative stimulator programming and patient care requires a multi-disciplinary team including movement disorders specialists in neurology and functional neurosurgery. To treat medically refractory levodopa-induced motor complications or resistant tremor the preferred target for high-frequency DBS is the subthalamic nucleus (STN). STN-DBS results in significant reduction of dyskinesias and dopaminergic medication, improvement of all cardinal motor symptoms with sustained long-term benefits, and significant improvement of quality of life when compared with best medical treatment. These benefits have to be weighed against potential surgery-related adverse events, device-related complications, and stimulus-induced side effects. The mean disease duration before initiating DBS in PD is currently about 13 years. It is presently investigated whether the optimal timing for implantation may be at an earlier disease-stage to prevent psychosocial decline and to maintain quality of life for a longer period of time.
Preference for Online Social Interaction (2003)

The model introduced and tested in the current study suggests that lonely and depressed individuals may develop a preference for online social interaction, which, in turn, leads to negative outcomes associated with their Internet use. Participants completed measures of preference for online social interaction, depression, loneliness, problematic Internet use, and negative outcomes resulting from their Internet use.Results indicated that psychosocial health predicted levels of preference for online social interaction, which, in turn, predicted negative outcomes associated with problematic Internet use. In addition, the results indicated that the influence of psychosocial distress on negative outcomes due to Internet use is mediated by preference for online socialization and other symptoms of problematic Internet use.T he results support the current hypothesis that that individuals’ preference for online, rather than face-to-face, social interaction plays an important role in the development of negative consequences associated with problematic Internet use.
Energetics of Leucyl-Leucine Hydrolysis in <i>Streptococcus cremoris</i> Wg <sub>2</sub> (1986)

The hydrolysis of the dipeptide leucyl-leucine by whole cells of Streptococcus cremoris Wg(2) was dependent on the presence of the energy source lactose. Incubation of cells with uncouplers or ATPase inhibitors prevented the increase of peptidase activity upon the addition of lactose. Incubation with the ionophore nigericin resulted in decreased peptide hydrolysis activity, while incubation with valinomycin led to increased hydrolysis activity. In the presence of nigericin the DeltapH component of the proton motive force was decreased, while the electrical potential was increased. With valinomycin, the electrical potential was collapsed and the DeltapH was increased. When the external pH was decreased from 8 to 5, the rate of peptide hydrolyzing activity by whole cells increased with increasing DeltapH component. In contrast, the peptide hydrolyzing activity in the cell extract decreased with decreasing external pH. These results indicate that the DeltapH component of the proton motive force determines the leucyl-leucine hydrolyzing activity in S. cremoris Wg(2).
Microwave frequency synthesis using injection locked laser comb line selection (2005)

Microwave frequency synthesis can be realised by mixing the output of two or more DFB lasers injection locked to the same optical comb. The noise and stability problems of this approach are studied.
Interstitial Cystitis: Evaluation and Related Conditions (2009)

No AccessJournal of UrologyEditorial1 Jun 2009Interstitial Cystitis: Evaluation and Related Conditionsis companion ofThe Relationship Among Symptoms, Sleep Disturbances and Quality of Life in Patients With Interstitial CystitisUrodynamic Findings of the Painful Bladder Syndrome/Interstitial Cystitis: A Comparison With Idiopathic Overactive Bladder Durwood E. Neal Durwood E. NealDurwood E. Neal More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2009.03.032AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Interstitial Cystitis: Evaluation and Related Conditions." The Journal of Urology, 181(6), pp. 2414–2415 References 1 : Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases Workshop on Interstitial Cystitis, National Institutes of Health, Bethesda, Maryland, August 28–29, 1987. J Urol1988; 140: 203. Link, Google Scholar 2 : The interstitial cystitis symptom index and problem index. Urology1997; 49: 58. Google Scholar 3 : Efficiency of questionnaires used to screen for interstitial cystitis. J Urol2006; 176: 587. Link, Google Scholar 4 : Significance of hematuria in patients with interstitial cystitis: review of radiographic and endoscopic findings. Urology2001; 57: 262. Google Scholar 5 : The role of cystoscopy in the diagnosis of Hunner's ulcer disease. J Urol2008; 180: 1383. Link, Google Scholar 6 : An assessment of the use of intravesical potassium in the diganosis of interstitial cystitis. J Urol1999; 162: 699. Link, Google Scholar 7 : Logical and systematic approach to the evaluation and management of patients suspected of having interstitial cystitis. Urology1997; 49: 114. Google Scholar 8 Neal DE: Diagnosis of malignancy in an interstitial cystitis population. Unpublished data. Google Scholar Division of Urology, University of Missouri, Columbia, Missouri© 2009 by American Urological AssociationFiguresReferencesRelatedDetailsRelated articlesJournal of Urology16 Apr 2009The Relationship Among Symptoms, Sleep Disturbances and Quality of Life in Patients With Interstitial CystitisJournal of Urology16 Apr 2009Urodynamic Findings of the Painful Bladder Syndrome/Interstitial Cystitis: A Comparison With Idiopathic Overactive Bladder Volume 181Issue 6June 2009Page: 2414-2415 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Durwood E. Neal More articles by this author Expand All Advertisement PDF downloadLoading ...
Toll-like Receptor 4 Modulation as a Strategy to Treat Sepsis (2010)

Despite a decrease in mortality over the last decade, sepsis remains the tenth leading causes of death in western countries and one of the most common cause of death in intensive care units. The recent discovery of Toll-like receptors and their downstream signalling pathways allowed us to better understand the pathophysiology of sepsis-related disorders. Particular attention has been paid to Toll-like receptor 4, the receptor for Gram-negative bacteria outer membrane lipopolysaccharide or endotoxin. Since most of the clinical trial targeting single inflammatory cytokine in the treatment of sepsis failed, therapeutic targeting of Toll-like receptor 4, because of its central role, looks promising. The purpose of this paper is to focus on the recent data of various drugs targeting TLR4 expression and pathway and their potential role as adjunctive therapy in severe sepsis and septic shock.
Edge computing in the extreme and its applications (2016)

The notion of edge computing introduces new computing functions away from centralized locations and closer to the network edge and thus facilitating new applications and services. This enhanced computing paradigm is provides new opportunities to applications developers, not available otherwise. In this talk, I will discuss why placing computation functions at the extreme edge of our network infrastructure, i.e., in wireless Access Points and home set-top boxes, is particularly beneficial for a large class of emerging applications. I will discuss a specific approach, called ParaDrop, to implement such edge computing functionalities, and use examples from different domains -- smarter homes, sustainability, and intelligent transportation -- to illustrate the new opportunities around this concept.
Regulation of the L‐type Ca <sup>2+</sup> channel during cardiomyogenesis: switch from NO to adenylyl cyclase‐mediated inhibition (1999)

In adult mammalian cardiomyocytes, stimulation of muscarinic receptors counterbalances the beta-adrenoceptor-mediated increase in myocardial contractility and heart rate by decreasing the L-type Ca2+ current (ICa) (1, 2). This effect is mediated via inhibition of adenylyl cyclase and subsequent reduction of cAMP-dependent phosphorylation of voltage-dependent L-type Ca2+ channels (3). Little is known, however, about the nature and origin of this pivotal inhibitory pathway. Using embryonic stem cells as an in vitro model of cardiomyogenesis, we found that muscarinic agonists depress ICa by 58 +/-3% (n=34) in early stage cardiomyocytes lacking functional beta-adrenoceptors. The cholinergic inhibition is mediated by the nitric oxide (NO)/cGMP system since it was abolished by application of NOS inhibitors (L-NMA, L-NAME), an inhibitor of the soluble guanylyl cyclase (ODQ), and a selective phosphodiesterase type II antagonist (EHNA). The NO/cGMP-mediated ICa depression was dependent on a reduction of cAMP/protein kinase A (PKA) levels since application of the catalytic subunit of PKA or of the PKA inhibitor PK) prevented the carbachol effect. In late development stage cells, as reported for ventricular cardiomyocytes (2, 4), muscarinic agonists had no effect on basal ICa but antagonized beta-adrenoceptor-stimulated ICa by 43 +/-4% (n=16). This switch in signaling pathways during development is associated with distinct changes in expression of the two NO-producing isoenzymes, eNOS and iNOS, respectively. These findings indicate a fundamental role for NO as a signaling molecule during early embryonic development and demonstrate a switch in the signaling cascades governing ICa regulation.
Über ternäre Metall‐Bornitride (1961)

Abstract Durch Erhitzen eines Gemisches von Lithiumnitrid, Calciumnitrid, Bariumamid mit Bornitrid auf 700–1000° wurden ternäre Nitride dieser Metalle mit Bor erhalten. Durch Variation der Mischungsverhältnisse konnte die Zusammensetzung zu Li 3 BN 2 , Ca 3 B 2 N 4 und Ba 3 B 2 N 4 ermittelt werden. Die Verbindungsbildung wurde nachgewiesen durch Farbänderungen, durch die große Löslichkeit in Wasser, bzw. verdünnter kalter Salzsäure und durch Debye‐Scherrer‐Aufnahmen. Die Infrarot‐spektren sprechen für das Ion NBN 3− ; lediglich in der Calciumverbindung liegt daneben vielleicht ein hochmolekulares Ion vor. Ähnliche Versuche mit Kaliumamid, Magnesiumnitrid, Gallium‐ und Lanthannitrid verliefen erfolglos.
Beneficial Dog Bacteria Up-Regulate Oxytocin and Lower Risk of Obesity (2017)

Cohabitation with pet dogs imparts diverse health benefits to humans including a slim physique. It is known that neuropeptide hormone oxytocin fundamental in human-canine social bonds regulates appetite and body weight. It was recently shown in mice that consuming Lactobacillus reuteri ATCC 6475 from human breast milk lowers body weight and up-regulates oxytocin levels in blood. Here we test the hypothesis that bacteria from dog saliva may similarly modulate recipient host body weight. We find that a Lactobacillus spp isolate from dog saliva led to lower body weight when fed to C57BL/6 wild type mice. Mice consuming the canineborne L. reuteri also had elevated oxytocin levels in blood plasma, and exhibited body weight in an oxytocin-dependent manner. Interestingly, killed (lysed) canine bacteria were sufficient to achieve the physiological effects. Taken together, these studies provide evidence that dog bacteria modulate oxytocin levels and body weight in recipient mice, and thus may help reduce risk of obesity in individuals cohabitating with pet dogs.
MPEG-4 AAC audio decoding on a 24-bit fixed-point dual-DSP architecture (2002)

MPEG-4 audio coding is a recent audio standard that integrates a wide range of different types of audio coding, and, thus, applies to almost every audio application today. A very important subpart of MPEG-4 is the Advanced Audio Coding (AAC) algorithm, which has already distinguished itself in industry due to its high audio quality. This paper describes implementation of an AAC decoder on a novel dual-DSP architecture utilizing cost-effective 24-bit fixed-point arithmetic.