gebhart/patrepeval huggingface dataset:
Polypeptides. V. The Infrared Spectra of Polypeptides Derived from γ-Benzyl-L-glutamate (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolypeptides. V. The Infrared Spectra of Polypeptides Derived from γ-Benzyl-L-glutamateE. R. Blout and A. AsadourianCite this: J. Am. Chem. Soc. 1956, 78, 5, 955–961Publication Date (Print):March 1, 1956Publication History Published online1 May 2002Published inissue 1 March 1956https://doi.org/10.1021/ja01586a022RIGHTS & PERMISSIONSArticle Views331Altmetric-Citations116LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (764 KB) Get e-Alerts Get e-Alerts
Genome-Wide Analysis Reveals Loci Encoding Anti-Macrophage Factors in the Human Pathogen Burkholderia pseudomallei K96243 (2010)

Burkholderia pseudomallei is an important human pathogen whose infection biology is still poorly understood. The bacterium is endemic to tropical regions, including South East Asia and Northern Australia, where it causes melioidosis, a serious disease associated with both high mortality and antibiotic resistance. B. pseudomallei is a Gram-negative facultative intracellular pathogen that is able to replicate in macrophages. However despite the critical nature of its interaction with macrophages, few anti-macrophage factors have been characterized to date. Here we perform a genome-wide gain of function screen of B. pseudomallei strain K96243 to identify loci encoding factors with anti-macrophage activity. We identify a total of 113 such loci scattered across both chromosomes, with positive gene clusters encoding transporters and secretion systems, enzymes/toxins, secondary metabolite, biofilm, adhesion and signal response related factors. Further phenotypic analysis of four of these regions shows that the encoded factors cause striking cellular phenotypes relevant to infection biology, including apoptosis, formation of actin 'tails' and multi-nucleation within treated macrophages. The detailed analysis of the remaining host of loci will facilitate genetic dissection of the interaction of this important pathogen with host macrophages and thus further elucidate this critical part of its infection cycle.
Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C (2008)

Reliable diagnosis is a diagnostic index devoted to clinical practice. Its rate can be increased by creating new intervals between diagnostic cut-off and 90% PVs or sensitivity/specificity thresholds. This increased the overall accuracy from 78.1 to 89.5% and reduced the need for a liver biopsy from 56.5 to 0% with the most accurate test.
Adjustment off predetection filters in high-speed data transmission systems (1990)

The paper presents four schemes for the adaptive adjustment of a linear feedforward filter placed ahead of a conventional digital data detector. The filter is broadly adjusted according to two criteria, those of maximisation of the signal-tonoise ratio at the input of the detector where perfect equalisation of the detector input signal results in zero intersymbol interference, or minimising the mean-square error present in the equalised signal at the detector input. The paper presents the results of extensive computer simultions performed upon models of the four schemes when operating over four different voice-frequency bandpass channels. The results are arranged to show the relative accuracies and complexities (in terms of the number of arithmetic operations required to implement the algorithms) of the tested systems. Furthermore, the results have been arranged to show the behaviour of the four systems in the presence of additive white Gaussian noise and various amounts of distortion introduced by the channels, for different lengths of the linear pre-filter.
Decreased intracellular calcium mediates the histamine H <sub>3</sub> -receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings (2001)

Activation of presynatic histamine H(3) receptors (H(3)R) down-regulates norepinephrine exocytosis from cardiac sympathetic nerve terminals, in both normal and ischemic conditions. Analogous to the effects of alpha(2)-adrenoceptors, which also act prejunctionally to inhibit norepinephrine release, H(3)R-mediated antiexocytotic effects could result from a decreased Ca(2+) influx into nerve endings. We tested this hypothesis in sympathetic nerve terminals isolated from guinea pig heart (cardiac synaptosomes) and in a model human neuronal cell line (SH-SY5Y), which we stably transfected with human H(3)R cDNA (SH-SY5Y-H(3)). We found that reducing Ca(2+) influx in response to membrane depolarization by inhibiting N-type Ca(2+) channels with omega-conotoxin (omega-CTX) greatly attenuated the exocytosis of [(3)H]norepinephrine from both SH-SY5Y and SH-SY5Y-H(3) cells, as well as the exocytosis of endogenous norepinephrine from cardiac synaptosomes. Similar to omega-CTX, activation of H(3)R with the selective H(3)R-agonist imetit also reduced both the rise in intracellular Ca(2+) concentration (Ca(i)) and norepinephrine exocytosis in response to membrane depolarization. The selective H(3)R antagonist thioperamide prevented this effect of imetit. In the parent SH-SY5Y cells lacking H(3)R, imetit affected neither the rise in Ca(i) nor [(3)H]norepinephrine exocytosis, demonstrating that the presence of H(3)R is a prerequisite for a decrease in Ca(i) in response to imetit and that H(3)R activation modulates norepinephrine exocytosis by limiting the magnitude of the increase in Ca(i). Inasmuch as excessive norepinephrine exocytosis is a leading cause of cardiac dysfunction and arrhythmias during acute myocardial ischemia, attenuation of norepinephrine release by H(3)R agonists may offer a novel therapeutic approach to this condition.
Accurate analysis of mechanical stress in dielectric multilayers (2017)

We present a systematic study of a stress coefficient of dielectric materials (SiO<sub>2</sub>, Nb<sub>2</sub>O<sub>5</sub>, and HfO<sub>2</sub>). In particular, we show a thickness dependence of the stress coefficient on layer thickness, which shows that the determination of this coefficient is complex and requires careful analysis. We then apply the different models of the stress coefficient to multilayer structures and show that stress-induced deformation can be precisely predicted in final components with a few percent accuracy.
An Ordered Form of the Extra-Large-Pore Zeolite UTD-1:  Synthesis and Structure Analysis from Powder Diffraction Data (1999)

A highly crystalline sample of the extra-large-pore, high-silica zeolite UTD-1 has been prepared in fluoride medium. The resulting product (UTD-1F) has a powder diffraction pattern remarkably different from that published for the calcined form of conventionally prepared UTD-1, and it could only be indexed on a monoclinic unit cell. The crystal structure was determined ab initio in the space group P21/c from synchrotron powder diffraction data collected on a textured sample. The resulting structure, with 69 non-H atoms in the asymmetric unit, is by far the largest structure solved directly from powder diffraction data to date. Subsequent Rietveld refinement of the structure in Pc, with 349 positional parameters and 464 geometric restraints, proved to be surprisingly stable and converged with RF = 0.041 and Rwp = 0.134 (Rexp = 0.101). In contrast to the structure reported for calcined UTD-1, no evidence of disorder was found in the UTD-1F framework (structure type code DON). There is a strict up−down alternation of the orientation of the Si tetrahedra in the 14-rings, and double crankshaft chains link adjacent 14-ring channels. Not only the framework, but also the (Cp*)2Co complex, which appeared very clearly on the difference electron density map, was found to be fully ordered in the channels with the 5-fold axis parallel to the channel direction.
Linear, or "Small-signal," theory for the Gunn effect (1966)

A model wherein the density of free carriers in the conduction band of a semiconductor is dependent on the electric field and decreases at high fields is considered. The growth and phase velocity of an RF wave of small amplitude which propagates through the medium are evaluated. From these properties the threshold electric field and the frequency tuning characteristics vs. electric field for an oscillating sample are calculated. In high-resistivity samples are predicted 1) the threshold field to increase with increasing resistivity, and 2) the oscillating frequency to decrease when the field is increased above threshold. Experimental data which are consistent with both of these predictions are presented.
Response of physeal cartilage to low-level compression and tension in organ culture. (1998)

The clinical response of growth plate to exogenous forces is well recognized, although the organ-level mechanisms are poorly understood. Physeal cartilage from 5- to 7-day-old bovine distal radii was subjected to 245 N of tension or 245 N of compression (0.012 MPa) in organ culture over a 24-h period. Eleven specimens (six tension, five compression) were assayed for cellular proliferation with tritiated thymidine. Eighteen specimens (12 tension, six compression) were assayed for synthetic activity with radioactive sulfate. Media were assayed for prostaglandin production. Tension increased whereas compression decreased synthetic activity and prostaglandin production by physeal cartilage in explant culture over a 24-h period. There was no significant change in thymidine uptake. Physeal cartilage can respond to both tension and compression and, in the short term, appears to alter synthetic activity without changing the rate of cell proliferation. This study system allows local sampling and manipulation of the physeal organ environment and may lead to ways of approaching growth-plate pathologies in vivo.
Nonlinear distortion generated by DSF-based optical-phase conjugators in analog optical systems (2002)

In this paper, the nonlinear distortion induced by dispersion-shifted-fiber-based optical-phase conjugators (OPCs) in intensity-modulated subcarrier multiplexing optical systems is evaluated. In this study, it is shown that the nonlinear distortion mainly arises from the four-wave mixing (FWM) process during the phase conjugation, although there also exists influences from other nonlinear effects. Closed expressions for calculating the second- and third-order harmonic distortions due to FWM, self-phase modulation, cross-phase modulation and group-velocity dispersion effects in the dispersion-shifted-fiber-based OPC are also reported for the first time. The influence of several system design parameters, such as the optical modulation index, the number of channels, the input optical powers, and the effective area of the dispersion-shifted fiber on the compensation of fiber-induced nonlinear distortions employing the optical-phase conjugation technique, is considered.
Characterization of adhesive properties of red blood cells using surface acoustic wave induced flows for rapid diagnostics (2014)

This letter presents a method which employs surface acoustic wave induced acoustic streaming to differentially peel treated red blood cells (RBCs) off a substrate based on their adhesive properties and separate populations of pathological cells from normal ones. We demonstrate the principle of operation by comparing the applied power and time required to overcome the adhesion displayed by healthy, glutaraldehyde-treated or malaria-infected human RBCs. Our experiments indicate that the method can be used to differentiate between various cell populations contained in a 9 μl droplet within 30 s, suggesting potential for rapid diagnostics.
Assessment of Fitness Tracker Security: A Case of Study (2018)

The wearable industry has experienced a notable growth over the last decade, especially in fitness or e-health trackers. These trackers bring new functionalities that require collecting a great amount of sensitive information about the user. This fact has made fitness trackers the target of deliberate attacks, e.g., eavesdropping, unauthorized account access, fake firmware update, and so on. For this reason, this paper describes a vulnerability study on one of the most popular fitness trackers in 2017, together with the mobile application associated to the tracker. The study results show what vulnerabilities of the communications among agents (i.e., wearable device, mobile application and server) could put at risk users sensitive information and privacy.
Phase Transfer Catalysis without Solvent. Synthesis of Bisazolylalkanes (1992)

The reaction of asoles and benzasoles with dihalomethanes and dihaloethanes was performed in the absence of solvent.This 8ethod provides a general procedure for the synthesis of bisarolylmethanes and ethanes.No solvent was used during the reaction and, when possible, during the work-up.Polyazolylborate anions have been widely used as complexation agents.*As an extension N-h~polyazolylmethanes and -ethanes have a growing interest as neutral l i g a n d ~. ~ However, complex synthesis of the azolylalkanes and low yields reduced the usefulness of these compounds.The application of Phase Transfer Catalysis (P.T.C.) provided a useful method for the preparation of azolylmethanes.~This method was extended to various azoles, ~y r a z o l e s , ~ 1,2,4-triazole~,~ imidaso~es,~ henzotriazoles6 and also to tris-and tetralisazolylmethanes6*' and hisasol~lethanes.~The advantages of P.T.C. were, .orereadily available and less toxic reagents, easier experimental procedures, higher yields and a wider scope than previous ~t h o d s .~ Scheme 1We are interested in the use of azolylmethanes and -ethanes, in coordination chemistry, in deprotonation followed by electrophilic addition reactions and in the synthesis of azapentalene systems (Scheme 1).
Balanced P-Code: A RAID-6 Code to Support Highly Balanced I/Os for Disk Arrays (2014)

There exist numerous erasure codes for RAID-6, of which MDS codes are popular due to the optimal storage efficiency. Although vertical MDS codes have better load balancing compared to horizontal MDS codes, unbalancing problem still exists in some vertical codes, e.g., P-Code. To address this issue, we propose a novel efficient RAID-6 code to support highly balanced I/Os among disk arrays - Balanced P-Code. In Balanced P-Code, We move the unevenly distributed information symbols in each parity chain of P-Code along their columns to other rows, thus enabling the parity chain to keep original parity calculation relationships and tolerate double disk failures. The Balanced P-Code can not only achieve optimal storage efficiency, computational complexity and update complexity, but also support better I/O balancing in the context of large scale storage systems. Apart from extensive theoretical analysis, empirical evaluation are conducted by running a wide range of workloads under various configurations. Experimental results show that Balanced P-Code has better load balancing ratio. Especially, in both random mixed single read/write and random mixed continuous read/write cases, Balanced P-Code outperforms P-Code in terms of load balancing ratio by a factor of up to 2.64 and 2.3, respectively.
Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study. (1997)

The current study demonstrates the presence of a 4,977 bp deletion in human mitochondrial DNA genome that is associated with aging and with some forms of presbycusis. These results, coupled with previous animal studies, suggest that this 4,977 deletion may be associated with presbycusis.
Making, probing and understanding Bose-Einstein condensates (1999)

Contribution to the proceedings of the 1998 Enrico Fermi summer school on Bose-Einstein condensation in Varenna, Italy.
Light‐Harvesting Metallosupramolecular Squares Composed of Perylene Bisimide Walls and Fluorescent Antenna Dyes (2006)

The fluorescent dye 4-dimethylamino-1,8-naphthalimide was incorporated at the bay area of N,N'-bispyridyl perylene bisimide to afford a fourfold-functionalized perylene bisimide ligand. Through self-assembly directed by metal-ion coordination, a multichromophore supramolecular entity composed of sixteen dimethylaminonaphthalimide antennas and a perylene bisimide-walled square core was subsequently constructed from this linear ditopic ligand and 90 degrees metal corner [Pd(dppp)](OTf)2 (dppp=1,3-bis(diphenylphosphino)propane; OTf=trifluoromethanesulfonate) in good yield. The isolated metallosupramolecular square was characterized by elemental analysis and 1H, 13C, and 31P{1H} NMR and UV/Vis spectroscopy. Furthermore, by means of 1H NMR diffusion-ordered spectroscopy (DOSY) the dimension of this assembly was evaluated by employing a previously reported perylene bisimide ligand and its square assembly as references. The results obtained confirm the square framework of the current assembly. The optical properties of this multichromophore dye assembly were investigated by UV/Vis and steady-state and time-resolved fluorescence spectroscopy. It was revealed that light captured by dimethylaminonaphthalimide antennas could be efficiently transported to the perylene bisimide core by a fluorescence resonance mechanism (energy-transfer efficiency E=95%), and this resulted in almost exclusive detection of intense perylene bisimide emission, irrespective of the excitation wavelength applied. The present square scaffold containing aminonaphthalimide antenna dyes exhibits more than seven times higher fluorescence quantum yield (Phifl=0.37) than a previously reported pyrene-bearing perylene bisimide-walled square (Phifl=0.05). Thus, this multichromophore square assembly with aminonaphthalimide antenna dyes is an artificial model for the cyclic light-harvesting complexes in purple bacteria.
Biochemical surface modification of Ti-6Al-4V for the delivery of protein to the cell-biomaterial interface. (1997)

Biochemical surface modification involves delivery of biomolecules to the tissue-implant interface to induce desired cell and tissue responses. We have previously had success in immobilizing and retaining bioactive molecules on Co-Cr-Mo but not on Ti-6Al-4V. The purpose of this study was to modify the gamma-aminopropyltriethoxysilane (APS) scheme to enable successful attachment of protein to the surface of Ti-6Al-4V. Ti-6Al-4V samples were silanized with organic (acetone) solutions of APS and dried at increasing temperatures. Concentrations resulting in 2-4 NH2 per nm2 of nominal surface area were incubated in physiological saline for up to 96 hr to assess retention of amino groups. A model protein, trypsin, was coupled to silanized Ti-6Al-4V via glutaraldehyde. The samples were then incubated in saline, and the activity of residual immobilized enzyme was quantified. After drying at 45, 80, or 115 degrees C, the NH2 groups were lost from the surface by 24 hr of incubation in saline. On samples dried at 150 degrees C, with 4% APS, the number of NH2 groups increased after 8 hr and remained relatively constant through 96 hr. Likewise, at 150 degrees C with 2% APS the surface density of NH2 groups reached a maximum at 24 hr and remained relatively constant up to 96 hr. When incubated for 96 hr, Ti-6Al-4V with 4% APS and dried at 150 degrees C retained approximately 31% of the activity initially immobilized, whereas protein on 45 degrees C or adsorbed samples was lost by 24-48 hr.
Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene. (1997)

To test the hypothesis that the transforming growth factor-beta (TGF-beta) system has tumor suppressor activity in the mammary gland, we have generated transgenic mice overexpressing a dominant-negative mutant form of the type II TGF-beta receptor, under the control of the mouse mammary tumor virus-long terminal repeat. High-level expression of the transgene was observed in the mammary and salivary glands, with lower expression in the lung, spleen, and testis. Older nulliparous transgenic mice (9-17 months) showed a marked increase in the incidence and degree of lobulo-alveolar side-branching in the mammary glands when compared to wild-type littermates (24.8% of glands examined histologically versus 14.4%; P = 0.004), suggesting a role for endogenous TGF-betas in regulating development or maintenance of mammary alveoli. Spontaneous tumorigenesis was unchanged in the transgenic mice. However, following initiation with the carcinogen 7,12-dimethylbenz[a]anthracene, the transgenic group showed a significant increase in the incidence and multiplicity of mammary tumors when compared with wild-type littermates (40% incidence in transgenic mice versus 22% for wild-type, with 4 of 25 transgenics developing multiple mammary tumors versus 0 of 27 wild-type; P = 0.03). An early increase in the incidence of lung tumors was also observed in transgenic mice, but no difference between genotype groups was seen in the incidence of tumors in tissues in which the transgene is not expressed. The data show that the endogenous TGF-beta system has tumor suppressor activity in the mammary gland and lung.
Increasing the Efficiency of Data Storage and Analysis Using Indexed Compression (2009)

The massive data sets produced by the high- throughput, multidimensional mass spectrometry instruments used in proteomics create challenges in data acquisition, storage and analysis. Data compression can help mitigate some of these problems but at the cost of less efficient data access, which directly impacts the computational time of data analysis. We have developed a compression methodology that 1) is optimized for a targeted mass spectrometry proteomics data set and 2) provides the benefits of size and speed from compression while increasing analysis efficiency by allowing extraction of segments of uncompressed data from a file without having to uncompress the entire file. This paper describes our compression algorithm, presents comparative metrics of compression size and speed, and explores approaches for applying the algorithm to a generalized data set.
Improved Syntheses of 1<i>H</i>-Benz[<i>f</i>]indene (1991)

1,3-Cyclopentadiene, excess sodium hydride, and α, α, α′-tribromo-o-xylene react to give 1H-benz[f]indene in a 25% yield. α, α, α′, α′ -Tetrabromo-o-xylene, 2-cyclopenten-1-one, and excess sodium iodide react to from benz[f]indan-1-one. Lithium aluminum hydride reduction of benz[f] indan-1-one and dehydration of benz[f]indan-1-ol forms the title molecule in an overall yield of 40%