gebhart/patrepeval huggingface dataset:
Academy for Eating Disorders International Conference on Eating Disorders (2003)

The focus of this meeting was the interface between eating disorders and obesity. A symposium at this meeting dealt with advances in treatment for bulimia nervosa (BN) and binge eating disorder. There were two presentations in this symposium that addressed pharmacological treatments. One reviewed drug treatments for BN, which included reviewing the evidence for the efficacy of tricyclic antidepressants, monoamine oxidase inhibitors and selective serotonin inhibitors in the treatment of BN. All drug studies demonstrated greater reduction in binge eating and purging than with placebo. Other medications studied without evidence of efficacy for BN include opiate antagonists, lithium and anticonvulsants. Two promising agents for BN that require further study are odansitron and topiramate. For binge eating disorder, studies have examined the efficacy of antidepressants (tricyclic antidepressants, selective serotonin re-uptake inhibitors and serotonin/noradrenaline re-uptake inhibitors), antiobesity agents (sibutramine) and antiepileptics associated with weight loss (topiramate), with some evidence of efficacy for these agents.
X-Ray Study of the Graphitization of Carbon Black (1954)

A picture of the early stage of graphitization of a carbon black has been obtained from an x-ray study of a Fine Thermal (FT) carbon black heated for two hours at 2300°C. Nearest neighbor pairs of layers take on the graphite relation independently, producing both ABA and ABC sequences. There are two nearest neighbor layer spacings 3.35 A and 3.44 A corresponding to pairs with the graphite relation and pairs with random orientation. The (00l) peaks must be corrected for the distortion broadening resulting from the two spacings, to obtain the parallel layer group thickness Lc. The probability for the ordering of nearest neighbor layers P1 is defined as the ``degree of graphitization.'' A logarithmic plot is used for a rapid determination of P1 and the layer diameter La from the modulated two dimensional (hk) reflections.
Strengthening Alginate/Polyacrylamide Hydrogels Using Various Multivalent Cations (2013)

We successfully synthesized a family of alginate/polyacrylamide hydrogels using various multivalent cations. These hydrogels exhibit exceptional mechanical properties. In particular, we discovered that the hydrogels cross-linked by trivalent cations are much stronger than those cross-linked by divalent cations. We demonstrate stretchability and toughness of the hydrogels by inflating a hydrogel sheet into a large balloon, and the elasticity by using a hydrogel block as a vibration isolator in a forced vibration test. The excellent mechanical properties of these hydrogels may open up applications for hydrogels.
The Selective Hydrogenation of Derivatives of Pyrrole, Indole, Carbazole and Acridine (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Selective Hydrogenation of Derivatives of Pyrrole, Indole, Carbazole and AcridineHomer Adkins and Harry L. CoonradtCite this: J. Am. Chem. Soc. 1941, 63, 6, 1563–1570Publication Date (Print):June 1, 1941Publication History Published online1 May 2002Published inissue 1 June 1941https://pubs.acs.org/doi/10.1021/ja01851a020https://doi.org/10.1021/ja01851a020research-articleACS PublicationsRequest reuse permissionsArticle Views911Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Salt Triggers the Simple Coacervation of an Underwater Adhesive When Cations Meet Aromatic π Electrons in Seawater (2017)

Adhesive systems in many marine organisms are postulated to form complex coacervates (liquid-liquid phase separation) through a process involving oppositely charged polyelectrolytes. Despite this ubiquitous speculation, most well-characterized mussel adhesive proteins are cationic and polyphenolic, and the pursuit of the negatively charged proteins required for bulk complex coacervation formation internally remains elusive. In this study, we provide a clue for unraveling this paradox by showing the bulky fluid/fluid separation of a single cationic recombinant mussel foot protein, rmfp-1, with no additional anionic proteins or artificial molecules, that is triggered by a strong cation-π interaction in natural seawater conditions. With the similar condition of salt concentration at seawater level (>0.7 M), the electrostatic repulsion between positively charged residues of mfp-1 is screened significantly, whereas the strong cation-π interaction remains unaffected, which leads to the macroscopic phase separation (i.e., bulky coacervate formation). The single polyelectrolyte coacervate shows interesting mechanical properties including low friction, which facilitates the secretion process of the mussel. Our findings reveal that the cation-π interaction modulated by salt is a key mechanism in the mussel adhesion process, providing new insights into the basic understanding of wet adhesion, self-assembly processes, and biological phenomena that are mediated by strong short-range attractive forces in water.
Discovery and characterization of highly immunogenic and broadly recognized mimics of the HIV‐1 CTL epitope Gag<sub>77–85</sub> (2005)

Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL) play an important role in HIV infection. Given the viral genetic diversity, the selection of suitable antigens and epitope variants will be important in the design of an effective vaccine. We have previously shown that combinatorial libraries are useful tools to identify epitope mimics as well as potentially cross-reactive natural sequences in protein databases. We have applied this approach to the HIV Gag p17-derived epitope SL9 (SLYNTVATL) to identify broadly recognized SL9 mimics and to assess the cross-recognition of naturally occurring SL9 variants. Nine nonapeptides were identified that were up to one order of magnitude more effective than SL9 in stimulating CTL responses in PBMC from HIV-infected subjects. Using transgenic mice, we demonstrate that a number of these epitope mimics were able to generate de novo T cell responses that cross-reacted with the original SL9 sequence. Particularly, mimics with changes at the relatively conserved F-pocket anchor residue were frequently cross-recognized. This approach may lead to vaccine candidates with higher in vivo immunogenicity and increased potential for cross-recognition of naturally occurring SL9 variants.
Preparation and characterization of iron complexes of the penta-p-tolylcyclopentadienyl and o-tolyltetraphenylcyclopentadienyl ligands (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and characterization of iron complexes of the penta-p-tolylcyclopentadienyl and o-tolyltetraphenylcyclopentadienyl ligandsLeslie D. Field, Anthony F. Masters, Michelle Gibson, Devin R. Latimer, Trevor W. Hambley, and Irmi E. BuysCite this: Inorg. Chem. 1993, 32, 2, 211–217Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/ic00054a016https://doi.org/10.1021/ic00054a016research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Development of a Detector for Ultratrace Nitrogen in Argon Using Low-Pressure, Capillary Glow Discharge Molecular Emission Spectrophotometry (1997)

A highly sensitive detector was developed for determining parts per billion of nitrogen in high-purity argon. The method is based on the spectrophotometric determination of the emission intensity from the nitrogen molecule excited in the lowest vibrational transitions of the electronic C3Πu → B3Πg system. A capillary glow discharge technique was applied to excite nitrogen in an argon flow at several Torr. The low-pressure, capillary glow discharge method offered high sensitivity for detecting trace nitrogen in argon. The response of the detector was proportional in the range of nitrogen concentrations from 0.1 ppb, which correspond to S/N = 3, to 100 ppm.
Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms (2001)

Mammalian chloride intracellular channel (CLIC) (p64-related) proteins are widely expressed, with an unusual dual localization as both soluble and integral membrane proteins. The molecular basis for their cellular localization and ion channel activity remains unclear. To help in addressing these problems, we identified novel rat brain CLIC4 (p64H1) binding partners by affinity chromatography, mass spectrometric analysis and microsequencing. Brain CLIC4 binds dynamin I, α-tubulin, β-actin, creatine kinase and two 14-3-3 isoforms; the interactions are confirmed in vivo by immunoprecipitation. Gel overlay and reverse pull-down assays indicate that the binding of CLIC4 to dynamin I and 14-3-3∊ is direct. In HEK-293 cells, biochemical and immunofluorescence analyses show partial co-localization of recombinant CLIC4 with caveolin and with functional caveolae, which is consistent with a dynamin-associated role for CLIC4 in caveolar endocytosis. We speculate that brain CLIC4 might be involved in the dynamics of neuronal plasma membrane microdomains (micropatches) containing caveolin-like proteins and might also have other cellular roles related to membrane trafficking. Our results provide the basis for new hypotheses concerning novel ways in which CLIC proteins might be associated with cell membrane remodelling, the control of cell shape, and anion channel activity.
Composition, Red Blood Cell Uptake, and Serum Protein Binding of Phytoestrogens Extracted from Commercial Kudzu-Root and Soy Preparations (2002)

Kudzu-root and soy phytoestrogens have been associated with anti-cancer and anti-intoxication activities. Sales of capsules containing kudzu-root and soy extracts through health food stores and the Internet are unregulated. To compare efficacy, the amount of phytoestrogens present in commercial preparations and their fate in biological samples must be determined. In this study, the levels and composition of phytoestrogens in kudzu-root and soy extracts were studied using high-performance liquid chromatography with ultraviolet light detection. The bioavailability of phytoestrogens was studied by measuring red blood cell (RBC) uptake and serum protein binding ability. Phytoestrogen levels in acidified kudzu-root samples were 5- to 10-fold greater than those in nonacidified samples. Puerarin accounted for 80% of total phytoestrogens in kudzu-root. In soy extract, puerarin was absent while genistin, glycetein, and daidzin or daidzein were the major phytoestrogens. The RBC uptake depended on the phytoestrogen's polarity and molecular length. When serum was dialyzed with phytoestrogen standards in a buffer, the protein binding of phytoestrogens correlated negatively with their polarity. However, when serum was dialyzed with kudzu-root or soy extract, almost all of the phytoestrogens present in the extract bound to serum protein. Therefore, this study suggests differences in the bioavailability of phytoestrogens when they are ingested as purified compounds compared with crude plant extract. The differential composition of phytoestrogens in kudzu-root and soy may account for the differences in their therapeutic activities.
Introduction au dossier critique : Histoire (1967) (2010)

Comment est-il possible que de tant d'histoires ou plutôt fragments d'histoires, superposés ou enchevêtrés, il subsiste une histoire et qui plus est, inscrite dans l'Histoire ou du moins dans les réseaux aussi complexes que confus de l'Histoire ? Est-il imaginable d'ailleurs qu'un moi indubitablement vivant ait pu sortir de ces cohortes de « fantômes bâillonnés par le temps » ? Question lancinante assurément, portée, d'une certaine manière, par la narration du roman Histoire de Claude Simon, ...
Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines. (1999)

We have assessed in detail the effect of cisplatin-activated programmed cell death in the cisplatin-sensitive human ovarian cancer cell line A2780 and two drug-resistant subclones, CP70 and C30. To determine whether the differential extent of apoptosis observed between the sensitive and resistant ovarian cancer cell lines was the result of dissimilar upstream signaling events, we assessed the execution of apoptotic events that precede target protein proteolysis and subsequent chromosomal DNA degradation. Proteolytic degradation of procaspase-3 was observed in both the CP70 and C30 cells following IC50 cisplatin treatment, whereas no proteolyzed caspase-3 subunits were detected in the A2780 cells. However, using a direct enzymatic assay measuring cleavage of the synthetic peptide substrate (N-acetyl-Asp-Glu-Val-Asp-p-nitroanilide), activity was detected in extracts prepared from A2780 cells treated at the IC90 level of cisplatin and was 2-3-fold less than that of extracts prepared from CP70 and C30 cells. Because the activation of procaspase-3 by caspase-9 requires the release of cytochrome c into the cytoplasm, we determined the level of cytoplasmic cytochrome c in each cell line in response to cisplatin treatment. Consistent with the caspase-3 activation data, a very small increase in cytoplasmic cytochrome c was observed in A2780 cells following cisplatin treatment, whereas dramatic increases were evident in both the CP70 and C30 cell lines. The expression of the mitochondrial factors Bcl-2, Bcl-x, and Bax was determined because each has been implicated in the regulation or release of cytochrome c at the level of the mitochondria. Bcl-2 and Bcl-xL proteins remained relatively unchanged in expression for over 48 h after exposure to cisplatin in the A2780 cell lines. However, within the same time period, expression of Bcl-2 decreased in the CP70- and C30-resistant cell lines, whereas an increase in Bcl-xL expression was observed. Expression of the proapoptotic Bcl-xS protein was observed in only the resistant CP70 and C30 cell lines independent of cisplatin treatment. A change in the expression of Mr 24,000 Bax to a Mr 21,000 isoform was evidenced in the A2780 cells within 48 h of cisplatin treatment and, to a greater extent, in the CP70 and C30 cells, which also expressed a Mr 16,000 Bax variant. Evidence for an alternative apoptotic pathway in A2780 cells was obtained by demonstrating increased FADD expression in response to cisplatin treatment. These results support a model in which cisplatin-induced programmed cell death in the cisplatin-sensitive A2780 and -resistant CP70 and C30 cells proceeds via caspase-3-independent and -dependent pathways, respectively.
Effects of ventriculectomy, prosthetic laryngoplasty, and exercise on upper airway function in horses with induced left laryngeal hemiplegia. (1988)

Effects of ventriculectomy and prosthetic laryngoplasty on upper airway flow mechanics and blood gas tensions in exercising horses with induced left laryngeal hemiplegia were assessed. Five adult horses were trained to stand, trot (4.5 m/s), and gallop (7.2 m/s) on a treadmill (6.38 degrees incline). Inspiratory and expiratory airflows (VImax, VEmax, respectively) were measured using a 15.2-cm diameter pneumotachograph in a face mask. Inspiratory and expiratory transupper airway pressures (PuI, PuE, respectively) were determined as pressure differences between barometric pressure and lateral tracheal pressure. Blood collected from exteriorized carotid arteries was analyzed for PaO2, PaCO2, pH, hemoglobin (Hb) content, and HCO3- values. Heart rate (HR) was determined with an HR monitor. Measurements were made with horses standing, trotting, and galloping before left recurrent laryngeal neurectomy (LRLN; base line), 14 days after LRLN, 30 days after ventriculectomy (44 days after LRLN), and 14 days after prosthetic laryngoplasty (58 days after LRLN). Before LRLN (base line), increasing treadmill speed for horses from standing to the trot and gallop progressively increased HR, respiratory frequency, VImax, VEmax, PuI, PuE, Hb, and PaCO2 values and decreased PaO2, pH, and HCO3- values; inspiratory and expiratory impedances were unchanged. After LRLN, inspiratory impedance and PuI were significantly (P less than 0.05) increased in horses at the trot and gallop, and PaCO2 was significantly increased in horses at the gallop. The VImax and respiratory frequency were significantly (P less than 0.05) decreased in horses at the gallop. Left recurrent laryngeal neurectomy had no effect on PuE, VEmax, HR, PaO2, pH, Hb, or expiratory impedance values.(ABSTRACT TRUNCATED AT 250 WORDS)
A joint particle filter for audio-visual speaker tracking (2005)

In this paper, we present a novel approach for tracking a lecturer during the course of his speech. We use features from multiple cameras and microphones, and process them in a joint particle filter framework. The filter performs sampled projections of 3D location hypotheses and scores them using features from both audio and video. On the video side, the features are based on foreground segmentation, multi-view face detection and upper body detection. On the audio side, the time delays of arrival between pairs of microphones are estimated with a generalized cross correlation function. Computationally expensive features are evaluated only at the particles' projected positions in the respective camera images, thus the complexity of the proposed algorithm is low. We evaluated the system on data that was recorded during actual lectures. The results of our experiments were 36 cm average error for video only tracking, 46 cm for audio only, and 31 cm for the combined audio-video system.
Jet engine life prediction systems integrated with prognostics health management (2004)

Tracking real-time onboard component damage accumulation for jet engine rotating structures inside an integrated prognostics and health management system is an improvement over current engine component life tracking processes. A new advanced life prediction system provides a comprehensive and reliable prognostics tool capable of identifying remaining life on major life limited rotating components driving engine maintenance actions. This prognostics tool consists of algorithms generated from component structural models and design criteria at critical engine operating conditions. Tool output is damage accumulated, required to calculate remaining life estimate of the component, used to project next maintenance action.
Complementary and Alternative Medicine Use by Osteoporotic Patients in Australia (CAMEO-A): A Prospective Study (2010)

Patients attending osteoporosis clinics frequently use CAM. Physicians may need to routinely inquire about a history of CAM use to ensure better screening for possible adverse clinical interactions.
ChemInform Abstract: Diastereoselective Cyclization of a Glycylalanine Azomethine to an Imidazolidinone: Determination of the Product Configuration by X‐Ray Analysis. (1989)

Abstract The glycylalanine ester (I) is coupled with the aldehyde (II) to give the azomethine (III) which is cyclized and subsequently treated with the chloroformate (IV), forming the diastereomeric imidazolidines (V) and (VI).
Protective effect of taurine and zinc on peroxidation‐induced damage in photoreceptor outer segments (1984)

Exposure of isolated frog rod outer segments (ROS) to ferrous sulfate in a Krebs-bicarbonate medium causes a time-dependent disruption of the membrane organization of the discs. Ferrous sulfate also causes ROS swelling and aggregation. Addition of taurine (5-20 mM) and zinc sulfate (250 microM) to the incubation medium markedly protected ROS from the disrupting effect of ferrous sulfate. Of other amino acids tested, only beta-alanine had a protective effect on ROS structure. Ferrous sulfate caused an increase in lipid peroxidation, measured by malonaldehyde formation. The protective effect of taurine and zinc is not accompanied by a reduction of lipid peroxidation. Water accumulation occurs as a consequence of the peroxidative action of ferrous sulfate, and this effect was counteracted by taurine and zinc. Ferrous sulfate did not cause damage to ROS structure when incubation was carried out in sucrose-HEPES. Sodium, chloride, and bicarbonate ions caused ferrous sulfate to disrupt ROS structure. It is concluded that taurine and zinc protect ROS membranes from ion and/or water entry occurring as a consequence of membrane lipid peroxidation.
Dielectric function and reflectivity of 3C–silicon carbide and the component perpendicular to the <i>c</i> axis of 6H–silicon carbide in the energy region 1.5–9.5 eV (1996)

The optical properties of commercially available 3C- and 6H-SiC single crystals were studied in the energy region 1.5–9.5 eV with conventional and synchrotron-radiation spectroscopic ellipsometry. The surface perfection of the materials was investigated by transmission electron and atomic force microscopies. The calculated values for the effective and static dielectric functions were higher than those found in the literature. This is consistent with the fine structure and absolute values of the corresponding reflectance spectra, which were higher than those reported in other studies. The dispersion of the refractive indices in the energy region below and above the indirect gap is determined and can be used as reference and for the design and analysis of semiconductor structures and devices.
REVIEWS Thémes et Figures du Siécle des Lumiéres. Melanges offerts à MORTTERROLAND. Edited par TROUSSONRAYMOND. (Histoire des idées et critique litté'raire,192). Genéve: Droz. 1980. 343 pp. 65 SW.F. (1983)

REVIEWS Get access Thémes et Figures du Siécle des Lumiéres. Melanges offerts à ROLAND MORTTER. Edited par RAYMOND TROUSSON. (Histoire des idées et critique litté'raire,192). Genéve: Droz. 1980. 343 pp. 65 SW.F. O.R. TAYLOR O.R. TAYLOR LONDON Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XXXVII, Issue 4, October 1983, Pages 467–468, https://doi.org/10.1093/fs/XXXVII.4.467 Published: 01 October 1983