gebhart/patrepeval huggingface dataset:
A modular and turn-key remote-access hardware-in-the-loop platform for testing electric motors (2014)

This paper details the architecture, hardware and software of a platform for testing electric motors over the Internet that enables users to test multiple physical motors remotely under the specific loading conditions of the real-world application for which a motor is required. The system is divided into three major modules: the Server Software Application, the Target Software Application and the Motor Test Platform. The system is unique as it combines modularity, scalability and deliverability. It is modular, as it is capable of readily testing a variety of electric motors, scalable, as new motors can be quickly added to the system for testing, and is turn-key, easily deployed and installed. The proof-of-concept prototype was developed and examined against benchmark tests to determine its capabilities. The platform was effective as a remote access emulation and evaluation tool.
Metatranscriptomic and Thermodynamic Insights into Medium-Chain Fatty Acid Production Using an Anaerobic Microbiome (2018)

Biomanufacturing from renewable feedstocks can offset fossil fuel-based chemical production. One potential biomanufacturing strategy is production of medium-chain fatty acids (MCFA) from organic feedstocks using either pure cultures or microbiomes. While the set of microbes in a microbiome can often metabolize organic materials of greater diversity than a single species can and while the role of specific species may be known, knowledge of the carbon and energy flow within and between organisms in MCFA-producing microbiomes is only now starting to emerge. Here, we integrated metagenomic, metatranscriptomic, and thermodynamic analyses to predict and characterize the metabolic network of an anaerobic microbiome producing MCFA from organic matter derived from lignocellulosic ethanol fermentation conversion residue. A total of 37 high-quality (>80% complete, <10% contamination) metagenome-assembled genomes (MAGs) were recovered from the microbiome, and metabolic reconstruction of the 10 most abundant MAGs was performed. Metabolic reconstruction combined with metatranscriptomic analysis predicted that organisms affiliated with <i>Lactobacillus</i> and <i>Coriobacteriaceae</i> would degrade carbohydrates and ferment sugars to lactate and acetate. <i>Lachnospiraceae</i>- and <i>Eubacteriaceae</i>-affiliated organisms were predicted to transform these fermentation products to MCFA. Thermodynamic analyses identified conditions under which H<sub>2</sub> is expected to be either produced or consumed, suggesting a potential role of H<sub>2</sub> partial pressure in MCFA production. From an integrated systems analysis perspective, we propose that MCFA production could be improved if microbiomes were engineered to use homofermentative instead of heterofermentative <i>Lactobacillus</i> and if MCFA-producing organisms were engineered to preferentially use a thioesterase instead of a coenzyme A (CoA) transferase as the terminal enzyme in reverse β-oxidation. <b>IMPORTANCE</b> Mixed communities of microbes play important roles in health, the environment, agriculture, and biotechnology. While tapping the combined activities of organisms within microbiomes may allow the utilization of a wider range of substrates in preference to the use of pure cultures for biomanufacturing, harnessing the metabolism of these mixed cultures remains a major challenge. Here, we predicted metabolic functions of bacteria in a microbiome that produces medium-chain fatty acids from a renewable feedstock. Our findings lay the foundation for efforts to begin addressing how to engineer and control microbiomes for improved biomanufacturing, how to build synthetic mixtures of microbes that produce valuable chemicals from renewable resources, and how to better understand the microbial communities that contribute to health, agriculture, and the environment.
Molecular Pharmacology of the Sodium Channel Mutation D1790G Linked to the Long-QT Syndrome (2000)

These results (1) demonstrate that the DG mutation confers a unique pharmacological response on expressed channels; (2) suggest that flecainide use-dependent block of DG channels underlies its therapeutic effects in carriers of this gene mutation; and (3) suggest a role of the Na(+) channel alpha-subunit C-terminus in the flecainide/channel interaction.
Preliminary Results of Combining Low Frequency Low Intensity Ultrasound and Liposomal Drug Delivery to Treat Tumors in Rats (2011)

Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nano-sized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] and alpha-tocopherol were loaded with Doxorubicin (Dox) using a pH gradient. The liposomal suspension was infused through the tail vein of BDIX rats possessing bilateral intradermal DHD/K12 tumors on their hind legs. Then 20-kHz ultrasound was applied to only one of the tumors for 15 minutes. This therapy was repeated weekly for 4 weeks. The results showed that in five of six rats, the tumors regressed to non-measurable size within 4 weeks. A paired comparison of the normalized size of the insonated and non-insonated tumors in the same rat indicated that the insonated tumors were smaller (p < 0.0001, n = 6 rats, 21 pairs). This observation has significant potential for non-invasive site-specific therapy of solid tumors.
Joint detection for multicarrier CDMA mobile radio systems. II. Detection techniques (2002)

For pt.I see ibid., p.991, 1996. Presently investigated multicarrier code division multiple access (MC-CDMA) concepts explicitly avoid the occurrence of intersymbol interference (ISI), which facilitates the use of simple receivers. Unfortunately, the application of such MC-CDMA concepts cannot be recommended in outdoor environments. In pt. I, an MC-CDMA concept, which overcomes this disadvantage, has been introduced and described mathematically for the first time. The presented MC-CDMA concept explicitly allows ISI. In order to mitigate the effects of multiple access interference (MAI) and ISI, the deployment of joint detection (JD) techniques is proposed. Four JD techniques which are suitable for the application in the presented MC-CDMA concept are introduced. Finally, the performance, which can be achieved by applying the proposed JD techniques in the presented MC-CDMA concept, is analyzed in the case of the uplink.
Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection (2011)

Cells of the immune system undergo homeostatic proliferation during times of lymphopenia induced by certain viral infections or caused by chemotherapy and radiation treatment. Natural killer (NK) cells are no exception and can rapidly expand in number when placed into an environment devoid of these cells. We explored the lifespan and function of mouse NK cells that have undergone homeostatic proliferation in various settings of immunodeficiency. Adoptive transfer of mature NK cells into lymphopenic mice resulted in the generation of a long-lived population of NK cells. These homeostasis-driven NK cells reside in both lymphoid and nonlymphoid organs for >6 mo and, similar to memory T cells, self-renew and slowly turn over at steady state. Furthermore, homeostatically expanded NK cells retained their functionality many months after initial transfer and responded robustly to viral infection. These findings highlight the ability of mature NK cells to self-renew and possibly persist in the host for months or years and might be of clinical importance during NK cell adoptive immunotherapy for the treatment of certain cancers.
Enabling the co-allocation of grid data transfers (2004)

Data-sharing scientific communities use storage systems as distributed data stores by replicating content. In such highly replicated environments, a particular dataset can reside at multiple locations and can thus be downloaded from any one of them. Since datasets of interest are significantly large in size, improving download speeds either by server selection or by co-allocation can offer substantial benefits. We present an architecture for co-allocating grid data transfers across multiple connections, enabling the parallel download of datasets from multiple servers. We have developed several co-allocation strategies comprising of simple brute-force, history-based and dynamic load balancing techniques as a means both to exploit rate differences among the various client-server links and to address dynamic rate fluctuations. We evaluate our approaches using the GridFTP data movement protocol in a wide-area testbed and present our results.
Postmortem Pump-Driven Reperfusion of the Vascular System of Porcine Lungs: Towards a New Model for Surgical Training (2014)

PP enables circulation in an isolated porcine lung model with an acceptable pressure-flow relationship resulting in an excellent recruitment of the vascular system. Despite these promising results, rupture of vessel walls may cause leaks. Further exploration of the perfusion capacities of PP in other organs is necessary. Eventually, this could lead to the development of reperfused Thiel embalmed human bodies, which have several applications.
A 3-Stage Machine Learning-Based Novel Object Grasping Methodology (2020)

The automatic grasping of objects previously unseen by a robotic system is a difficult task-of which there is currently no robust solution. The research presented in this article improves upon previous works that employ depth data and learning techniques to generate and select from a pool of hypothesised grasps by focusing on the pruning and selection process. In this work, a vision-based, sampling methodology that generates candidate grasps through a convolutional neural network is proposed. Each candidate grasp is assessed using scores derived from the candidate itself and other related input modalities-such as the centre of gravity of the object. The final selection is determined by a learning algorithm. To overcome human bias, objective measures of grasp performance are established that comprehensively measure the error introduced by the grasp trial itself. The proposed metrics are empirically demonstrated to quantify grasp quality, offer useful criteria for network training and provide better descriptive power than traditional measures of grasp outcome. Experimentation showed that the proposed methodology can generate a meaningful, final grasp within 1.3 seconds. Trials quantitatively demonstrate a small-object-in-isolation performance of 99%. For unknown objects, this equates to a 10% improvement relative to other similar methodologies. Testing also showed that grasp performance was improved by 5% when implementing the proposed metrics-compared to the baseline.
Über die adrenale Steroid‐Biosynthese <i>in vitro</i> I. Umwandlung endogener und exogener Vorstufen im Nebennieren‐Homogenat des Rindes (1965)

Abstract The conditions of the adrenal steroid biosynthesis in vitro have been thouroughly studied, using beef adrenal cortex homogenate with endogenous and exogenous precursors. The preformed endogenous precursor has been identified with cholesterol. Its aerobic incubation produced a 10–30‐fold increase of the amount of originally present corticosteroids, such as cortisol, corticosterone, aldosterone, 18‐hydroxy‐corticosterone and 19‐hydroxy‐corticosterone. From a wide variety of exogenous precursors studied so far, corticosterone proved quantitatively to be the best precursor for aldosterone, whereas the pathway involves probably 18‐hydroxy‐corti‐costerone. The results suggest that the optimal conditions for the formation of aldosterone are different from those for other corticosteroids. The methods used are fully described.
Layer-by-Layer Thinning of MoS<sub>2</sub> by Plasma (2013)

The electronic structures of two-dimensional materials are strongly dependent on their thicknesses; for example, there is an indirect to direct band gap transition from multilayer to single-layer MoS2. A simple, efficient, and nondestructive way to control the thickness of MoS2 is highly desirable for the study of thickness-dependent properties as well as for applications. Here, we present layer-by-layer thinning of MoS2 nanosheets down to monolayer by using Ar(+) plasma. Atomic force microscopy, high-resolution transmission electron microscopy, optical contrast, Raman, and photoluminescence spectra suggest that the top layer MoS2 is totally removed by plasma while the bottom layer remains almost unaffected. The evolution of Raman and photoluminescence spectra of MoS2 with thickness change is also investigated. Finally, we demonstrate that this method can be used to prepare two-dimensional heterostructures with periodical single-layer and bilayer MoS2. The plasma thinning of MoS2 is very reliable (with almost 100% success rate), can be easily scaled up, and is compatible with standard semiconductor process to generate heterostructures/patterns at nanometer scale, which may bring out interesting properties and new physics.
Acquisition of selectional patterns (1992)

Article Free Access Share on Acquisition of selectional patterns Authors: Ralph Grishman New York University, New York, NY New York University, New York, NYView Profile , John Sterling New York University, New York, NY New York University, New York, NYView Profile Authors Info & Claims COLING '92: Proceedings of the 14th conference on Computational linguistics - Volume 2August 1992 Pages 658–664https://doi.org/10.3115/992133.992172Online:23 August 1992Publication History 17citation199DownloadsMetricsTotal Citations17Total Downloads199Last 12 Months32Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Avian Flight (2006)

Bird flight has always intrigued mankind. This book provides an up-to-date account of the existing knowledge on the subject, offering new insights and challenges some established views. A brief history of the science of flight introduces the basic physical principles governing aerial locomotion. This is followed by chapters on the flight-related functional morphology. The anatomy of the flight apparatus includes the wings, tail, and body. Treatment of the wings emphasizes the difference in shape of the arm and hand part. The structural complexity and mechanical properties of feathers receive special attention. Aerodynamic principles used by birds are explained in theory by applying Newton’s laws, and in practice by showing the direction and velocity of the flow around the arm and hand wing. The Archaeopteryx fossils remain crucial to the understanding of the evolution of bird flight despite the recent discovery of a range of well-preserved ancient birds. A novel hypothesis explaining the enigmatic details of the Archaeopteryx remains and challenges established theories regarding the origin of bird flight. Take-off, flapping flight, gliding, and landing are the basic ingredients of bird flight, and birds use a variety of flight styles from hovering to soaring. Muscles are the engines that generate the forces required to control the wings and tail, and to work during flapping motion. The energy required to fly can be estimated or measured directly, and a comparison of the empirical results, provides insights into the trend in metabolic costs of flight of birds varying in shape and mass from hummingbirds to albatrosses.
Sanctions: The real effects in South Africa and Australia (1988)

An interesting incident, quickly forgotten, occurred in this country last year as part of the response to the second military coup in Fiji. A policy of imposing sanctions was urged upon the government in trade union circles, ostensibly in response to a request for help which had been made by trade union leaders in Fiji. Although formally supported by the ACTU, it was immediately opposed by the government and the idea was soon dropped.
Calibrated Funnel Trap for Quantifying Mosquito (Diptera: Culicidae) Abundance in Wells (1999)

Our article addresses the problems of sampling and quantifying the abundance of immature Aedes aegypti (L.) and other mosquitoes that use subterranean habitats such as wells and service manholes. Two versions of the funnel trap, Austrap and Vietrap, were extremely sensitive for detecting the presence of Ae. aegypti larvae in wells, and the modified version, the Vietrap, sampled on average 20.5% of 3rd and 4th instars when set overnight for 12 h. For both models, regression analyses between trap catch and absolute abundance indicated high coefficients of determination (R2 = 0.932 and 0.992) enabling accurate direct calibration. The effects of immature age, mosquito species, well diameter, and trap size on catch size were investigated. Because of its simplicity, efficacy, and inexpensiveness, the Vietrap will facilitate the comprehensive assessment of key larval habitats for Ae. aegypti, data critical for the development of effective control programs.
Localization of Diffusion-Based Inpainting in Digital Images (2017)

Image inpainting, an image processing technique for restoring missing or damaged image regions, can be utilized by forgers for removing objects in digital images. Since no obviously perceptible artifacts are left after inpainting, it is necessary to develop methods for detecting the presence of inpainting. In general, there are two main categories of image inpainting techniques: exemplar-based and diffusion-based techniques. Although several methods have been proposed for detecting exemplar-based inpainting, there is still no effective method for detecting diffusion-based inpainting. Usually, the tampered regions manipulated by diffusion-based inpainting techniques are much smaller than those manipulated by exemplar-based ones, presenting more challenges in detecting these regions. As a pioneering attempt, this paper proposes a method for the localization of diffusion-based inpainted regions in digital images. We first analyze the diffusion process in inpainting, and observe that the changes in the image Laplacian along the direction perpendicular to the gradient are different in the inpainted and untouched regions. Following this observation, we construct a feature set based on the intra-channel and inter-channel local variances of the changes to identify the inpainted regions. Finally, two effective post-processing operations are designed for further refining of the localization result. The extensive experimental results evaluated on both synthetic and realistic inpainted images show the effectiveness of the proposed method.
Millimeter-Wave Integrated Pyramidal Horn Antenna Made of Multilayer Printed Circuit Board (PCB) Process (2012)

Due to the low atmospheric absorption over W-band, numerous applications are expected, which should be developed at low cost. Short wavelength makes the dimension of antennas in this frequency range small, which usually requires sophisticated and expensive fabrication process. This communication presents a class of integrated wideband pyramidal horn antennas which can be made of low-cost multilayered printed circuit board (PCB) process. The proposed horn antenna radiates along the broadside to the substrate and uses substrate integrated waveguide (SIW) as its feeder. Transverse slot on the top metallic surface at the end of SIW is deployed to drive the horn antenna. Metalized via holes are used to synthesize the horn walls. The opening of the horn antenna is discretely flared from the bottom to the top layer. Measured bandwidth of the antenna is 35 GHz (70-105 GHz) while a relatively constant gain of 10 ± 1 dB is obtained over most of the bandwidth.
Cooperative Intersection Control Based on Virtual Platooning (2017)

This paper proposes a cooperative intersection control strategy, which aims to decrease the number of accidents and to increase the traffic flow at intersections. Existing high-level automation methodologies mainly focus on the determination of a safe crossing sequence of the involved vehicles, typically ignoring realistic vehicle dynamics aspects. The solution proposed in this paper, referred to as cooperative intersection control (CIC), takes into account the dynamics of the vehicles and is based on the novel concept of virtual platooning. Virtual platooning allows to form platoons of vehicles that are in different lanes of the intersection and have different directional intentions. Herewith, both safe passage of the vehicles through the intersection and a high intersection throughput (due to close “virtual” vehicle following) can be achieved. The performance of the proposed strategy is assessed, and a comparison between the CIC and an intersection controlled with traffic lights is presented.
Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing (2002)

The C-to-U editing of apolipoprotein-B (apo-B) mRNA is catalyzed by an enzyme complex that recognizes an 11-nt mooring sequence downstream of the editing site. A minimal holoenzyme that edits apo-B mRNA in vitro has been defined. This complex contains apobec-1, the catalytic subunit, and apobec-1 complementation factor (ACF), the RNA-binding subunit that binds to the mooring sequence. Here, we show that ACF binds with high affinity to single-stranded but not double-stranded apo-B mRNA. ACF contains three nonidentical RNA recognition motifs (RRM) and a unique C-terminal auxiliary domain. In many multi-RRM proteins, the RRMs mediate RNA binding and an auxiliary domain functions in protein–protein interactions. Here we show that ACF does not fit this simple model. Based on deletion mutagenesis, the RRMs in ACF are necessary but not sufficient for binding to apo-B mRNA. Amino acids in the pre-RRM region are required for complementing activity and RNA binding, but not for interaction with apobec-1. The C-terminal 196 amino acids are not absolutely essential for function. However, further deletion of an RG-rich region from the auxiliary domain abolished complementing activity, RNA binding, and apobec-1 interaction. The auxiliary domain alone did not bind apobec-1. Although all three RRMs are required for complementing activity and apobec-1 interaction, the individual motifs contribute differently to RNA binding. Point mutations in RRM1 or RRM2 decreased the Kd for apo-B mRNA by two orders of magnitude whereas mutations in RRM3 reduced binding affinity 13-fold. The pairwise expression of RRM1 with RRM2 or RRM3 resulted in moderate affinity binding.