gebhart/patrepeval huggingface dataset:
Simulation Model and Method for Active Torsional Vibration Control of an HEV (2018)

Hybrid electric vehicles (HEV) might cause new noise vibration and harshness (NVH) problems, due to their complex powertrain systems. Therefore, in this paper, a new longitudinal dynamic simulation model of a series-parallel hybrid electric bus with an active torsional vibration control module is proposed. First, the schematic diagrams of the simulation model architecture and the active control strategy are given, and the dynamic models of the main components are introduced. Second, taking advantage of the characteristics of hybrid systems, a method of determining the key dynamic parameters by a bench test is proposed. Finally, in a typical bus-driving cycle for Chinese urban conditions, time domain and frequency domain processing methods are used to analyze vehicle body jerk, fluctuation of rotational speed, and torsional angle of the key components. The results show that the active control method can greatly improve the system’s torsional vibration performance when switching modes and at resonance.
The Design and Synthesis of 1,4-Substituted Piperazine Derivatives as Triple Reuptake Inhibitors (2012)

Novel 1,4-substituted piperazine derivatives 5, Series A and B were designed by fragment analysis and molecular modification of 4 selected piperazine-containing compounds which possess antidepressant activity. We synthesized new 39 analogues of Series A and 10 compounds of Series B, respectively. The antidepressant screening against DA, NE, and serotonin neurotransmitter uptake inhibition was carried out using the Neurotransmitter Transporter Uptake Assay Kit. The compounds in Series B showed relatively higher reuptake inhibitory activity for SERT, NET, and DAT than those in Series A. The length of spacer between the central piperazine core and the terminal phenyl ring substituted at the piperazine ring in Series B seems to exert an important role in the activity.
Human plantar fascial dimensions and shear wave velocity change in vivo as a function of ankle and metatarsophalangeal joint positions (2020)

The plantar fascia (PF), a primary contributor of the foot arch elasticity, may experience slack, taut, and stretched states depending on the ankle and metatarsophalangeal (MTP) joint positions. Since PF has proximodistal site difference in its dimensions and stiffness, the response to applied tension can also be site specific. Furthermore, PF can contribute to supporting the foot arch while being stretched beyond the slack length, but it has never been quantitatively evaluated in vivo. This study investigated the effects of the ankle and MTP joint positions on PF length and localized thickness and shear wave velocity (SWV) at three different sites from its proximal to distal end using magnetic resonance and supersonic shear imaging techniques. During passive ankle dorsiflexion, rise of SWV, an indication of slack length, was observed at the proximal site when the ankle was positioned by 10°-0° ankle plantar flexion with up to 3 mm (+1.5%) increase in PF length. On the other hand, SWV increased at the distal site when MTP joint dorsiflexed 40° with the ankle 30°-20° plantar flexion, and in this position, PF was lengthened up to 4 mm (+2.3%). Beyond the slack length, SWV curvilinearly increased at all measurement sites toward the maximal dorsiflexion angle whereas PF lengthened up to 9 mm (+7.6%) without measurable changes in its thickness. This study provides evidence that the dimensions and SWV of PF change in a site-specific manner depending on the ankle and MTP joint positions, which can diversify foot arch elasticity during human locomotion.<b>NEW & NOTEWORTHY</b> Joint angle dependence and site specificity of the plantar fascial dimensions and SWV were examined by combining sagittal magnetic resonance and supersonic shear imaging techniques. We revealed that the site-specific changes in PF SWV were related to joint angle positions, i.e., PF slackness and elasticity changed in varying combinations of ankle and MTP angle. Our findings suggest that PF can elastically support the foot arch throughout the stance phase of human bipedal locomotion.
Automatic Distribution of Object-Oriented Programs (2003)

This dissertation shows that it is both desirable and feasible to distribute object-oriented programs automatically, and that static analysis of a program's source code is an indispensable means to that end. To demonstrate this, we have built a system named Pangaea, which analyzes the source code of Java programs, and distributes them automatically using arbitrary middleware platforms as a back-end. At run-time, Pangaea uses a generic migration subsystem that can monitor the interactions between selected objects and may migrate them automatically to reduce network communication, thus complementing the static placement decisions. This thesis makes three main research contributions. The first is a set of static analysis algorithms that allow our system to estimate a program's run- time structure and dynamic behavior. Based on this information, abstract distribution strategies for the program can be selected and specified, which is done partly by the programmer, and partly by automatic tools that assist him. The second contribution is that we show how the abstract distribution strategy can be implemented automatically on a given middleware platform. Pangaea achieves this by re-generating the source code of the centralized program, changing or adding whatever is necessary to express the distribution strategy that was specified during analysis. We can thus consider Pangaea a distributing compiler: the input language of this compiler is Java, and the target language is the particular Java dialect or configuration language required by the middleware platform to be used. The third contribution is that we show how a generic run-time system can monitor interactions between objects, and re-adjust their placement automatically. Our implementation and case studies allow us to evaluate the cost of such a migration system, suggesting to which extent it is useful and necessary to complement static analysis.
Abstract 2241: SHH pathway in uterine mesenchymal tumors (2014)

Abstract Background: Uterine leiomyoma (ULM) and leiomyosarcoma (ULMS) are smooth muscle tumors with distinct clinical behavior that can cause infertility and even lead to death. Little is known about the factors that influence these tumors biology. Identification of new molecular markers can help in the differential diagnosis between ULM from low grade ULMS. It was demonstrated that activation of the Sonic Hedgehog (SHH) signaling pathway is related to the development of several tumors, through its activity in the cell proliferation and differentiation. Here, we investigated the protein expression profile of SHH, PTCH1, SMO and GLI1 both ULM (including non-typical leiomyomas) and ULMS. Methods: We selected 57 samples of ULMS and 30 samples of ULM (10 samples non-typical - ULMA). All tissues were used in TMA construction. Immunohistochemistry reaction was performed using monoclonal antibody against SHH (1:50), PTCH (1:100), SMO (1:100) and GLI-1 (1:200) using sodium citrate pH 6,0 in pressure cooker. Results were evaluated by Aperio® automated method. Results: Our preliminary data showed similar protein profile between the leiomyosarcoma and non-typical leiomyoma. GLI 1 and PTCH showed higher expression compared to leiomyoma and myometrium (p&lt;0.05). SMO, and SHH showed higher expression only in leiomyossarcomas (p&lt;0.05). Conclusions: Ours preliminary results showed that expression of Sonic Hedgehog pathway members might play an important role in uterine smooth tumors, since ULMS showed higher levels of these proteins. However, the role of these proteins interactions must be clarified. Citation Format: Natalia Garcia, Faila C. Souza, Nilo Bozzini, Glauco Baiocchi, Isabela W. Cunha, Fernando A. Soares, Edmund C. Baracat, Kátia C. Carvalho. SHH pathway in uterine mesenchymal tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2241. doi:10.1158/1538-7445.AM2014-2241
Differential gain, differential index, and linewidth enhancement factor for a 4 μm superlattice laser active layer (1999)

We describe temporally and spectrally resolved measurements of the material differential gain, differential refractive index, and linewidth enhancement factor for a multilayer superlattice intended for use in midwave-infrared semiconductor lasers. We find good agreement between measured quantities and theoretical predictions based on a superlattice K⋅p formalism. The superlattice was designed for suppression of Auger recombination and intersubband absorption, and we find that the strategies employed in this process result in other characteristics that are desirable in a semiconductor laser gain medium. Specifically, for carrier densities and wavelengths appropriate to threshold in an optimized cavity configuration, this structure has a differential gain of approximately 1.5×10−15 cm2, a value comparable to that reported for near-infrared strained quantum wells. The peak gain and peak differential gain are nearly spectrally coincident, leading to a small value for the differential index. The large differential gain and small differential index result in a linewidth enhancement factor of less than one. This indicates that filamentation in high-power lasers based on this superlattice should be suppressed and that this structure is attractive for use in midwave-infrared lasers designed for spectrally pure operation.
Robust Statistical Procedures. (1978)

Background - Why Robust Procedures? Qualitative and Quantitative Robustness, Qualitative Robustness, Quantitative Robustness, Breakdown, Infinitesimal Robustness, Influence Function M-L and R-Estimates, L-Estimates, R-Estimates, Asymptotic Properties of M-Estimates, Asymptotically Efficient M-L, R-Estimates, Scaling Question Asymptotic Minimax Theory, Minimax Asymptotic Bias, Minimax Asymptotic Variance Multiparameter Problems, Generalities, Regression, Robust Covariances - the Affinely Invariant Case, Robust Covariances - the Coordinate Dependent Case Finite Sample Minimax Theory, Robust Tests and Capacities, Finite Sample Minimax Estimation Adaptive Estimates, Adaptive Estimates Robustness - Where Are We Now?, The First Ten Years - Influence Functions and Pseudovalues, Breakdown and Outlier Detection, Studentizing, Shrinking Neighbourhoods, Some Persistent Misunderstandings, Future Directions.
Topological Characterization of Nucleic Acid G‐Quadruplexes by UV Absorption and Circular Dichroism (2011)

Four-fold: Not just the identification, but also the rapid characterization and classification of nucleic acid G-quadruplexes into topology groups is feasible utilizing UV and circular dichroism (CD) spectroscopy (see picture). It is now possible to utilize inexpensive UV spectroscopy to achieve the same level of characterization previously only possible with CD spectroscopy.
Bacterial Meningitis in Burkina Faso: Surveillance Using Field-Based Polymerase Chain Reaction Testing (2004)

Precise and rapid identification of etiologic agents is critical for improvement in the treatment and prevention of meningitis, and, thus, PCR should be considered for wider use in Africa. Vaccines against Streptococcus pneumoniae, N. meningitidis (including serogroup W135), and H. influenzae type b all will have a major impact on the bacterial meningitis burden. Antibiotic recommendations need to consider the importance of S. pneumoniae, even during the epidemic season.
Detection of antibodies against human metapneumovirus by western blot using recombinant nucleocapsid and matrix proteins (2006)

Detection of antibodies against individual proteins of human metapneumovirus (hMPV) is important in the analysis of immune responses to hMPV. Specific antibodies against nucleocapsid (N) and matrix (M) proteins in 97 serum samples were tested by Western blot using recombinant N and M proteins of hMPV expressed in Escherichia coli. The results were compared with those of immunofluorescence assays (IFAs) based on hMPV-infected LLC-MK2 cells, which expressed the whole hMPV proteins. Thirty (61.2%) and 31 (63.3%) of 49 serum samples with titers of > or = 1:160 by IFA reacted with N and M proteins, respectively. Only 2 (4.2%) of 11 serum samples with titers of 1:80 by IFA reacted with N and M proteins. Antibodies against N and M proteins were not detected in 37 serum samples with titers of < 1:40 by IFA. These results indicate that the antibodies against N and M proteins are highly specific (100%) but less sensitive (42.1%, N protein; 40.8%, M protein) than those against whole proteins of hMPV detected by IFA. The reactivity of sera with the recombinant N protein and that with the recombinant M protein correlated well (correlation coefficient of 0.79), and the concordance of reactivities was 91% (kappa = 0.79). In summary, both recombinant N and M proteins of hMPV were antigenic, and the responses to N and M protein varied among patients. Therefore, Western blot using N and M proteins provide a useful tool for analysis of immune responses to hMPV.
Monoclonal antibody to tumor necrosis factor--alpha prevents lethal endotoxin sepsis in adult rhesus monkeys. (1992)

In a rhesus monkey endotoxin sepsis model established by intravenous administration of 300 mg/kg D-galactosamine and 0.1 microgram/kg lipopolysaccharide from Salmonella abortus equi, hemodynamic, respiratory, metabolic and hematologic variables; levels of blood gases; monkey leukocyte elastase levels, and blood plasma concentrations of tumor necrosis factor--alpha (TNF) were monitored for 6 hours after administration, and again after 24 hours. Thirty minutes after administration of lipopolysaccharide, either 15 mg/kg anti-TNF monoclonal antibody (MoAB; n = 6) or vehicle placebo (saline solution; n = 4) were given intravenously. During this short-term experiment the organ functions were not different between the treatment groups. However, anti-TNF MoAb afforded morphologic protection from heart, lung, liver, and kidney damage after lipopolysaccharide challenge. Coagulation responses (platelet count and levels of fibrinogen, antithrombin III, and thrombin-antithrombin III complex) were smaller in anti-TNF MoAB-treated monkeys. Plasma TNF levels (WEHI cell cytotoxicity assay) reached a peak (350 pg/ml) 60 minutes after lipopolysaccharide administration in vehicle control subjects but no TNF was detected in the anti-TNF MoAB-treated monkeys. All control animals died 67 +/- 30 hours after lipopolysaccharide administration from multiorgan failure. On the contrary, all anti-TNF MoAB-treated animals survived 14 days (p > 0.005 vs placebo group mortality). Thus in short-term monkey experiments our study indicates protection against lipopolysaccharide-induced endotoxin sepsis by anti-TNF MoAB, which may have clinical relevance for the treatment of human septicemia.
Pavement Asset Management (2015)

This book presents the current methodologies and practical applications of managing pavements. The book contains seven parts that include : Part I: The Evolution of Pavement Management; Part II: Data Requirements; Part III: Determining Present and Future Needs and Priority Programming of Rehabilitation and Maintenance; Part IV: Structural Design and Economic Analysis: Project Level; Part V: Implementation of Pavement Management Systems; Part VI: Examples of Working Systems; and Part VII: Looking Ahead. The chapters are: Introduction; Birth and Teen Years of Pavement Management; Pavement Management Development from 2010; Setting the Stage; Overview of Pavement Management Data Needs; Inventory Data Needs; Characterizing Pavement Performance; Evaluation of Pavement Structural Capacity; Evaluation of Pavement Surface Distress Condition Surveys; Evaluation of Pavement Safety; Combined Measures of Pavement Quality; Data Base Management; Communicating the Present Status of Pavement Networks; Establishing Criteria; Prediction Models for Pavement Deterioration; Determining Needs; Rehabilitation and Maintenance Alternatives; Priority Programming of Rehabilitation and Maintenance; Developing Combined Programs of Maintenance and Rehabilitation; A Framework for Pavement Design; The Mechanistic-Empirical Pavement Design Guide (MEPDG) Process for Pavement Design; The MEPDG for Design of New and Reconstructed Rigid Pavements; Rehabilitation of Existing Pavements; MEPDG in Practice; Economic Evaluation of Alternative Pavement Design Strategies and Selection of an Optimal Strategy; Steps and Key Components of Implementation; Role of Construction; Role of Maintenance; Research Management; Basic Features of Working Systems; Network Level Examples of Pavement Management; Project Level Examples of PMS Software; Highway Design Manual-4 (HDM-4) the Upgraded World Bank Model; City and County Pavement Management Systems; Airport Pavement Management; Analyzing Special Problems; Applications of Expert Systems Technology; New and Emerging Technologies; Institutional Issues and Barriers Related to Pavement Management Implementation; Cost and Benefits of Pavement Management; Future Direction and Need for Innovation in Pavement Management; and Developments in Asset Management.
Integrated windows-based control system for an electron microscope (1994)

A Windows application has been developed for management and operation of beam instruments such as electron or ion microscopes. It provides a facility that allows an operator to manage a complicated instrument with minimal effort, primarily under mouse control. The hardware control components used on similar instruments (e.g., the scanning transmission electron microscopes in our lab), such as toggles, buttons, and potentiometers for adjustments on various scales, are all replaced by the controls of the Windows application and are addressable on a single screen. The new controls in this program (via adjustable software settings) offer speed of response and smooth operation providing tailored control of various instrument parameters. Along with the controls offering single parameter adjustment, a two-dimensional control was developed that allows two parameters to be coupled and addressed simultaneously. This capability provides convenience for such tasks as ‘‘finding the beam’’ and directing it to a location of interest on the specimen. Using an icon-based display, this Windows application provides better integrated and more robust information for monitoring instrument status than the indicators and meters of the traditional instrument controls. As a Windows application, this program is naturally able to share the resources of the Windows system and is thus able to link to many other applications such as our image acquisition and processing programs. Computer control provides automatic protection and instant diagnostics for the experimental instrument. This Windows application is fully functional and is in daily use to control a new type of electron microscope developed in our lab.
Optical soliton transmission in a comb-like dispersion profiled fiber loop (1997)

We discuss properties of comb-like dispersion profiled fiber for optical soliton transmission and perform 10-ps soliton transmission experiment over 1000 km with the amplifier spacing of 80 km which corresponds to 3. 1 times dispersion distance.
Pyrido[2',1':2,3]imidazo[5,1-a]isoquinolinium cation (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrido[2',1':2,3]imidazo[5,1-a]isoquinolinium cationCharles K. Bradsher, John E. Boliek, and R. D. BrandauCite this: J. Org. Chem. 1970, 35, 8, 2495–2497Publication Date (Print):August 1, 1970Publication History Published online1 May 2002Published inissue 1 August 1970https://pubs.acs.org/doi/10.1021/jo00833a006https://doi.org/10.1021/jo00833a006research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
EUV characteristics of a high power and high repetition rate CO 2 laser driven Xe plasma (2005)

A CO<sub>2</sub> laser driven Xe jet plasma is presented as light source system for EUV lithography. A short-pulse TEA C0<sub>2</sub> master oscillator power amplifier system and a pre-pulse Nd:YAG laser were used for plasma generation. The dependence of EUV plasma parameters, e.g. conversion efficiency, plasma image and in-band and out-of-band spectra, on the delay time between the pre-pulse and the main pulse laser was investigated. A maximum conversion efficiency of 0.6 % was obtained at a delay time of about 200 ns. In addition, characteristics of fast ions were measured by the time-of-flight method. The peak energy of the fast ion energy distribution decreased significantly at delay times larger than 200 ns. This result is very promising with respect to collector mirror lifetime extension by magnetic field mitigation.
Core–shell TaOx@MnO<sub>2</sub>nanoparticles as a nano-radiosensitizer for effective cancer radiotherapy (2018)

Improving tumor oxygenation and concentrating X-ray radiation energy inside the tumor have received considerable attention in cancer radiotherapy. Herein, core-shell tantalum oxide@manganese dioxide (TaOx@MnO<sub>2</sub>) nanostructures are prepared as an efficient radiosensitizer for enhancing radiotherapy (RT). In these nanostructures, the TaOx core serves as a RT sensitizer that efficiently concentrates X-ray radiation energy inside the tumor, while the MnO<sub>2</sub> shell may trigger the decomposition of endogenous H<sub>2</sub>O<sub>2</sub> in the tumor microenvironment (TME) to generate oxygen and overcome hypoxia-associated radiation resistance. In vitro and in vivo experiments demonstrated that the synthesized TaOx@MnO<sub>2</sub>-PEG nanostructures could accomplish an excellent synergistic radiotherapy sensitization effect. Furthermore, TaOx@MnO<sub>2</sub>-PEG nanoparticles could also serve as promising agents for MR/CT dual-modal imaging. In brief, our study highlights a new type of multifunctional radiosensitizer agent to enhance radiotherapy treatment by means of simultaneously concentrating radiation energy inside tumors and overcoming tumor hypoxia, promising for applications in tumor radiotherapy.
Stereoselective mono- and bis-homologation of L-serinal via 2-trimethylsilylthiazole addition. The thiazole route to amino L-sugars and D-erythro-sphingosines (1988)

anti-Addition [92% diastereoselectivity (d.s.)] of 2-trimethylsilylthiazole (2) to O,N-protected L-serinal (1) and deblocking the formyl group in the resulting adduct, leads to the (2S,3S)-2,4-dihydroxy-3-aminobutanal derivative (7), which serves as a precursor both to masked 4-amino-4-deoxy-L-ribose/L-arabinose and D-erythro-C20-sphingosine.