gebhart/patrepeval huggingface dataset:
Low-cost optical sub-assemblies for metro access applications (2004)

The fiber optic communications industry is experiencing significant change as datacom 10 Gb/s Ethernet (10 GbE) networks merge with telecom SONET 10G networks in the drive to reach metro access applications. Lower data rate (1G Ethernet, 1G and 2G fiber channel, and SONET OC-48) applications have already merged to some extent as various versions are available within the SFF or SFP standard transceiver form factors. Traditional 10 Gb/s optical subassemblies (OSAs), developed for SONET OC-192 applications, used variations of the expensive butterfly type package. However, smaller form factor modules (such as the XFP that uses SFF optical connectors and LC duplex optical connectors) require much smaller OSAs. To meet the size limitation of packaging 10G OSAs into the XFP transceiver and also meet the 10 GbE market challenge of providing low-cost solutions, new 10 Gb/s OSA components are needed.
Analysis of IP Network Path Capacity Estimation Using a Variable Packet Size Method (2005)

Capacity estimation effective in an IP network path is a key enabling technology for proactive and reactive resource management as well as intelligent planning in next generation IP networks. We analyze capacity measurements at different Internet destinations. Particularly, we use the variable packet size (VPS) method to measure the per-hop capacity in some network paths. This method is based on round trip time (RTT) measurements as well as on the Internet control message protocol, ICMP. The RTT delay is approximated by a gamma distribution. We observe how the measurement accuracy of this active probing is affected by factors such as layer 2 device latencies, limited clock resolution at the probing host, or queuing delay. These factors cause non linearity on the RTT curves obtained and, consequently, inaccuracies on the estimation of path capacities. The use of robust regression to improve linear approximation in the VPS method is proposed. As a result, we obtain better qualitative and quantitative results.
Trans-Selective Conversions of γ-Hydroxy-α,β-Alkynoic Esters to γ-Hydroxy-α,β-Alkenoic Esters (2004)

Gamma-hydroxy-alpha,beta-acetylenic esters are used as precursors to prepare gamma-hydroxy-alpha,beta-alkenoic esters by means of trans-selective additions of two hydrogen atoms or one hydrogen atom and one iodine atom across the triple bonds. These methods allow for the preparation of beta-substituted and alpha,beta-disubstituted alkenoic esters in highly stereoselective manners. [reaction--see text]
Aging Skeletal Muscle (1994)

The mass of many weight-bearing muscles declines in old rats, secondary to the atrophy of fibers, particularly of type IIb, with relatively little loss of muscle fibers during most of the adult life span. In humans, muscle atrophy is the result of a combination of progressive fiber loss and fiber atrophy. In both species, the proportion of histochemically determined fiber types is relatively stable across the adult portion of the life span. The loss of strength in old age is predominantly accounted for by reduced muscle mass in humans and rats. Resistance training leads to increased muscle mass and strength in old humans and rats, primarily by increasing fiber CSA. Muscle capillarity is unchanged in old rats but decreases in old dogs. Apparently, capillarity declines in truly sedentary older people. Endurance training enhances capillarity, and old rats and humans can attain levels of capillarity comparable to their active young counterparts, even when performing considerably less exercise. Blood flow during contractile activity is reduced in male rats and humans but not in old female rats or dogs. Oxidative capacity declines in many muscles of sedentary old rats and humans. With endurance training, old individuals from both species attain levels of muscle oxidative capacity quite similar to those in identically training young individuals. Muscle insulin-stimulated glucose transport is enhanced in rats after a bout of exercise, regardless of age. Endurance training elevates muscle GLUT-4 levels in young and middle-aged, but not old, rats, perhaps because the old rats trained at slower treadmill speeds. Middle-aged (47-62 yr) men and women can substantially increase muscle GLUT-4 with relatively brief (12-14 wk) endurance training; older humans (> 70-80 yr) have not been studied. Endurance training leads to reduced LDH activity without altering PFK or phosphorylase in old rats and humans. Muscle glycogen depletion, CP depletion, and lactate accumulation during contractile activity are exaggerated in old rats, apparently secondary to reduced muscle oxidative capacity and blood flow. Resting muscle glycogen concentration is diminished in older humans, probably in part because of a more sedentary lifestyle. Although several months of endurance training raises muscle glycogen concentration in older people, it does not restore it to youthful levels. Endurance training can greatly improve endurance in old age, at least in part by the same mechanism originally described in youth, i.e., an increase in muscle oxidative capacity, which contributes to reduced glycogen depletion.(ABSTRACT TRUNCATED AT 400 WORDS)
User Preference for Product Information in Remote Purchase Environments. (2002)

While the appeal of shopping online is enormous, successful methods of attracting and keeping customers remain elusive. Product offerings, service, and price are important considerations in online shopping, and a useful and satisfying Web site is also a consideration for on-line success. This research investigates product presentation in remote purchase environments and whether to accommodate user preferences for information processing in that presentation. After simulating an on-line shopping experience, users were asked about their satisfaction with it. Results indicate that regardless of the individual information processing style, the sentential style Web site was preferred over the diagrammatic style of product presentation. However, a combination site including both pictures and text was preferred over the others. These results address a conflict between goals of fast download time and thorough product presentation. Pictures may represent confirmation of the verbal description and provides a holistic view of the product, which slightly increases satisfaction.
Cross-layer design for wireless networks (2003)

As the cellular and PCS world collides with wireless LANs and Internet-based packet data, new networking approaches will support the integration of voice and data on the composite infrastructure of cellular base stations and Ethernet-based wireless access points. This article highlights some of the past accomplishments and promising research avenues for an important topic in the creation of future wireless networks. We address the issue of cross-layer networking, where the physical and MAC layer knowledge of the wireless medium is shared with higher layers, in order to provide efficient methods of allocating network resources and applications over the Internet. In essence, future networks will need to provide "impedance matching" of the instantaneous radio channel conditions and capacity needs with the traffic and congestion conditions found over the packet-based world of the Internet. Furthermore, such matching will need to be coordinated with a wide range of particular applications and user expectations, making the topic of cross-layer networking increasingly important for the evolving wireless buildout.
Toughness Governs the Rupture of the Interfacial H-Bond Assemblies at a Critical Length Scale in Hybrid Materials (2013)

The geometry and material property mismatch across the interface of hybrid materials with dissimilar building blocks make it extremely difficult to fully understand the lateral chemical bonding processes and design nanocomposites with optimal performance. Here, we report a combined first-principles study, molecular dynamics modeling, and theoretical derivations to unravel the detailed mechanisms of H-bonding, deformation, load transfer, and failure at the interface of polyvinyl alcohol (PVA) and silicates, as an example of hybrid materials with geometry and property mismatch across the interface. We identify contributing H-bonds that are key to adhesion and demonstrate a specific periodic pattern of interfacial H-bond network dictated by the interface mismatch and intramolecular H-bonding. We find that the maximum toughness, incorporating both intra- and interlayer strain energy contributions, govern the existence of optimum overlap length and thus the rupture of interfacial (interlayer) H-bond assemblies in natural and synthetic hybrid materials. This universally valid result is in contrast to the previous reports that correlate shear strength with rupture of H-bonds assemblies at a finite overlap length. Overall, this work establishes a unified understanding to explain the interplay between geometric constraints, interfacial H-bonding, materials characteristics, and optimal mechanical properties in hybrid organic-inorganic materials.
On the theory of difference frequency generation and light rectification in the scanning tunnelling microscope (1992)

The problem of currents induced in the scanning tunnelling microscope due to incident laser radiation is analysed. The authors uses a light-binding description of the microscope tunnelling junction, and the interaction with the laser field is taken into account by an effective time-dependent coupling between tip and sample. The currents generated at frequencies that are linear combinations of the incident frequencies are then obtained with the help of a nonequilibrium Green's function formalism. Particular attention is paid to the rectification and difference frequency generation effects. In this work they extend previous results for the rectified current to the case where a direct bias is applied in addition to the laser field. It is shown that in the limit of very low frequencies the dynamical response may be deduced from the static characteristic curve. In order to compare with recent experimental data, they perform model calculations for a graphite sample and study the induced photocurrent as a function of bias voltage, tip-sample distance and photon energy. The limitations of the adiabatic approximation are discussed. Finally, they present results for the rectified current in the presence of an adsorbed molecule with a characteristic vibrational mode. The contribution from inelastic processes is obtained to the lowest order in the electron-phonon coupling. It is shown that the onset of inelastic tunnelling should be reflected as a singularity in the rectified current as a function of both bias voltage and photon energy.
Dentoalveolar morphology: evaluation of natural root form versus cylindrical implant fixtures. (1997)

The function of implant-supported restorations is now routinely achieved. As a result, the emphasis in restorative implant dentistry has shifted from function to aesthetics and the biocompatibility of the materials utilized. The learning objective of this article is to review the three major components essential to achieving natural aesthetics in implant-supported restorations--hard tissue dynamics, soft tissue dynamics, and dental aesthetics. Particular emphasis is directed to the dentoalveolar anatomy and morphology. Analysis of the tooth root morphology and dimensions has resulted in the design and fabrication of restorative components with dimensions that closely resemble the natural tooth anatomy and aesthetics. A system of transmucosal abutments has been designed, and its utilization is presented in this review.
OPTIMIZATION OF MUD HAMMER DRILLING PERFORMANCE - A PROGRAM TO BENCHMARK THE VIABILITY OF ADVANCED MUD HAMMER DRILLING (2002)

No abstract prepared.
HIV-1 Replication Is Differentially Regulated by Distinct Clinical Strains of Mycobacterium tuberculosis (2009)

These results provide a precedent for TB strain-specific effects upon HIV-1 replication and thus for TB strain-specific pathogenesis in the outcome of HIV-1/TB co-infection. MTb strain-specific factors and mechanisms involved in the regulation of HIV-1 during co-infection will be of importance in understanding the basic pathogenesis of HIV-1/TB co-infection.
Complex model simplification algorithm with improved error evaluation (2005)

Given the framework of incremental mesh simplification based on edge colapse, the paper proposes a mesh simplification algorithm using an improved approach for measuring simplification error. The algorithm uses edge collapse to simplify the triangle mesh and maintains surface error approxinations using c-error for the faces which have changed after edge collapse and d-error for the faces which become degenerated after edge collapse. Also, we report some results using a variety of computer graphics models, which can show that the algorithm can achieve the desired simplification effect.
Evidence for two different P<sub>2</sub>‐purinoceptors on β cell and pancreatic vascular bed (1987)

1 The effects of a 2-substituted analogue of adenosine 5'-triphosphate (ATP), 2-methylthioadenosine triphosphate (2-methylthio ATP) have been studied on insulin secretion and flow rate of the isolated pancreas of the rat, perfused in the presence of glucose (8.3 mM). 2 2-Methylthio ATP (16.5-1650 nM) increased insulin secretion in a biphasic and concentration-dependent manner; the kinetics were comparable to those previously obtained with ATP. A comparison of relative potency between ATP and 2-methylthio ATP showed that 2-methylthio ATP was 45 times more potent than ATP. 3 2-Methylthio ATP also provoked a transient decrease of the flow rate in a concentration-dependent manner but at concentrations (165-825 microM) about 1000 fold higher than those needed to increase insulin secretion. A comparison of relative potency between the natural derivative and 2-methylthio ATP showed that 2-methylthio ATP was only twice as potent as ATP. 4 These and other previous results (with phosphate-modified analogues of ATP) provide evidence for two different types of P2-purinoceptors on endocrine cell and vessel cells of the pancreas. A P2Y subtype, mediating an increase of insulin secretion, is present on the beta cell of the pancreas. A P2X subtype, mediating vasoconstriction, is present on the vascular bed of the rat pancreas.
Prevention of base excision repair by TRC102 (methoxyamine) potentiates the anti-tumor activity of pemetrexed in vitro and in vivo (2007)

13005 Background: TRC102 (methoxyamine) reverses resistance to alkylating agents by inhibiting base excision repair (BER; a mechanism of DNA repair), thereby increasing DNA strand breaks and potentiating the anti-tumor activity of alkylating agents without additional toxicity, Based on these data, TRC102 is currently being studied in combination with temozolomide in a phase 1 trial. We hypothesized that inhibition of BER by TRC102 would also increase DNA strand breaks and improve the anti-tumor activity of anti-metabolite chemotherapeutics, including pemetrexed, because these agents also produce AP sites that are recognized and repaired by BER. Methods: Pemetrexed- induced AP sites and BER inhibition was quantified using an apurinic/apyrimidinic (AP) site assay in vitro. Single and double DNA strand breaks were quantified by the Comet assay in vitro and anti-tumor activity was assessed in an in vivo xenograft study of subcutaneously implanted H460 human lung cancer cells. Results: Pemetrexed induced and TRC102 reduced the number of available AP sites in pemetrexed- treated H460 cells (by 60–80%), indicating successful inhibition of BER. TRC102 treatment increased DNA strand breaks in pemetrexed-treated H460 cells (2 fold increase versus treatment with pemetrexed alone). Premetrexed treatment alone and in combination with TRC 102 delayed tumor growth in vivo (tumor growth delay of 4.7 days in the 150 mg/m 2 pemetrexed alone group, 5.7 days in the 150 mg/m 2 pemetrexed + 2 mg/m 2 TRC102 group and 6.9 days in the 150 mg/m 2 pemetrexed + 4 mg/m 2 TRC102 group); in vivo systemic toxicity was not increased. TRC102 alone had no effect in vitro or in vivo. Conclusions: TRC102 effectively inhibits BER in lung cancer cells treated with pemetrexed. Inhibition of DNA repair by TRC102 results in an increase in DNA strand breaks and improved anti-tumor activity versus treatment with pemetrexed alone. Given its preclinical efficacy and safety profile, study of TRC102 combined with pemetrexed in a phase 1 trial is warranted. No significant financial relationships to disclose.
Synthesis of 1,4-Bis(phenylethynyl)benzenes and Their Application as Blue Phase Liquid Crystal Composition (2013)

A number of 1,4-bis(phenylethynyl)benzene derivatives (BPEBs) and their analogues with different numbers of side-substitute fluorine atoms on benzene rings, and alkyl chains, ethoxyl groups, fluorine atoms and trifluoromethyl groups as the end groups have been synthesized. The effects of the different substituents on their properties such as thermal behavior of melting point and clearing point, the temperature of nematic phase, optical anisotropy and dielectric anisotropy have been well investigated, and it has been found that some BPEBs have a wide range of the nematic phase temperature with high optical anisotropy (Δn) and acceptable dielectric anisotropy (Δε), which have been applied as the crucial compositions to constitute a liquid crystal mixture having the properties of Δε = 29.0 and Δn = 0.283 at 25 °C. With the addition of the chiral dopant to the obtained liquid crystal mixture, blue phase liquid crystal with a blue phase temperature range of 8 °C has been achieved.
Improved hepatocyte in vitro maintenance in a culture model with woven multicompartment capillary systems: Electron microscopy studies (1995)

Primary pig hepatocytes form a tissuelike structure in an in vitro culture model that has provision for three-dimensional cell orientation, cell aggregation, decentralized cell perfusion with low metabolite gradients, integral oxygenation, and nonparenchymal cell coculture. Scanning electron microscopy (SEM) has shown that hepatocytes spontaneously form aggregates in a three-dimensional structure between and on the surface of artificial capillaries. Transmission electron microscopy (TEM) has shown that after 7 weeks of in vitro perfusion, the cell ultrastructure remains similar to that of the parenchyma in vivo. Golgi complexes, active membrane processes, reorganization of cell junctions, and bile canaliculi-like intercellular spaces were demonstrated.
Evidence for type II cells as cells of origin of K-Ras–induced distal lung adenocarcinoma (2012)

Identifying the cells of origin of lung cancer may lead to new therapeutic strategies. Previous work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct junction as a cancer cell of origin when a codon 12 K-Ras mutant is induced via adenoviral Cre inhalation. In the present study, we use two "knock-in" Cre-estrogen receptor alleles to inducibly express K-RasG12D in CC10(+) epithelial cells and Sftpc(+) type II alveolar cells of the adult mouse lung. Analysis of these mice identifies type II cells, Clara cells in the terminal bronchioles, and putative bronchoalveolar stem cells as cells of origin for K-Ras-induced lung hyperplasia. However, only type II cells appear to progress to adenocarcinoma.
The loop antenna as a probe (1964)

The properties of circular and square loop antennas as probes for measuring the magnetic field are investigated. The response of an electrically small loop to the magnetic and the electric components of a given electromagnetic field is determined theoretically for singly- and doubly-loaded loops in terms of suitably defined constants. A system error ratio is defined as a measure of the ability of a given probe to discriminate against the effects of the electric field. An experimental procedure for measuring loop sensitivities in the elliptically polarized near field of a quarter-wave monopole is described. Experimental and theoretical results are compared. It is concluded that very large errors are possible when a singly-loaded loop is used to measure magnetic fields unless its diameter is less than <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.01\lambda</tex> . The doubly-loaded probe may be used with comparable accuracy when its diameter is as large as <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.15\lambda</tex> .
Selective Area Metal–Organic Vapor Phase Epitaxy of Nitride Semiconductors for Multicolor Emission (2009)

Selective area metal-organic vapor phase epitaxy (SA-MOVPE) allows in-plane control of emission wavelength by tailored width of masks. For InGaN/GaN multiple quantum wells (MQWs), modulation of luminescence wavelength was achieved based on a balance between vapor-phase diffusion of group-III precursors and their surface incorporation. For the basic understanding of the SA-MOVPE of nitride semiconductors, thickness profiles of GaN, InN, AlN, and InGaN layers around relatively wide (>10 mum) masks were investigated. The effective lateral diffusion length D/k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> , which is the ratio of the vapor-phase mass diffusivity of a precursor to its surface incorporation rate constant, was extracted for GaN and InN. The value was much larger for InN due to smaller surface incorporation rate. In the SA-MOVPE of InGaN bulk layer at around 800degC, indium incorporation rate seems to be limited by the surface flux of a gallium precursor, resulting in no variation in the indium content. Varied width of the InGaN wells by the existence of masks seems to govern the shift in the luminescence wavelength from InGaN/GaN MQWs. Therefore, design of the thickness distribution of GaN based on the quantitative model is essential to the controlled in-plane color modulation of solid-state lighting devices using SA-MOVPE.