gebhart/patrepeval huggingface dataset:
Coinfection with herpesviruses in young children of HIV-infected women. (1995)

Coinfection with herpesviruses in young children born to human immunodeficiency virus (HIV)-infected women was studied with blood samples from children who were 9-12 months and 15-24 months of age. Three groups of children were included: (I) HIV-uninfected, asymptomatic (HIV-); (II) polymerase chain reaction (PCR) and/or culture-positive and asymptomatic or mildly symptomatic (HIV+ asymptomatic); and (III) PCR and/or culture-positive and symptomatic (HIV+ symptomatic). Significantly more of the HIV+ symptomatic patients had cytomegalovirus (CMV) antibody than the HIV patients. In addition, CMV antibody levels were significantly higher in the HIV+ symptomatic patients than in either of the other two groups. Human herpesvirus 7 (HHV-7) antibody titers were significantly different among the three groups of patients; however, no pairwise comparisons were significant. No differences were found for HHV-6 or Epstein-Barr virus (EBV) antibody frequencies or titers. These findings suggest that infection with CMV is a cofactor or an opportunistic infection causing symptomatic HIV infections in young children.
DNA Aptamer Selected against Pancreatic Ductal Adenocarcinoma for <i>in vivo</i> Imaging and Clinical Tissue Recognition (2015)

In this work, we have developed a truncated DNA aptamer, termed XQ-2d, with high affinity and specificity for pancreatic ductal adenocarcinoma (PDAC). Aptamer XQ-2d selectively binds to PL45 cells with a dissociation constant in the nanomolar range, as determined by its recognition of PL45 tumor cells in mice. Moreover, XQ-2d shows better recognition ratio for 40 tissue sections of clinical PDAC samples (82.5%) compared to the initial cell-SELEX selection library (5%). Therefore, XQ-2d can be considered a promising candidate as a tool for PDAC diagnosis and treatment.
The actions of capsaicin applied topically to the skin of the rat on C‐fibre afferents, antidromic vasodilatation and substance P levels (1992)

1. Single applications of solutions of capsaicin were made to the intact skin of anaesthetized rats and the effects on cutaneous blood flow and the firing of C-nociceptor afferents determined. Blood flow was measured by laser-Doppler flowmetry. C-fibre activity was recorded from filaments dissected from the saphenous nerve. 2. Following the application of a capsaicin solution (concentration > or = 1 mM) to rat saphenous skin, low frequency firing occurred in C-polymodal nociceptors that sometimes continued for > 10 min. At the some time, large increases in skin blood flow occurred exceeding 300% in some instances. 3. After the initial excitation, some C-polymodal nociceptors lost their sensitivity to pressure whilst their sensitivity to heat was lost or enhanced depending on the vehicle used. 4. Sensitivity of C-polymodal nociceptors to heat recovered in < 1 day following a single application of 33 mM capsaicin. Thresholds to mechanical pressure, however, were still significantly elevated by 123% on day 1, but had recovered on day 2. 5. Vasodilatation in response to saphenous nerve stimulation ('antidromic vasodilatation') was significantly reduced by 35%, 2 days after a single application of 33 mM capsaicin, but was normal at 4 days. 6. Following a single application of 33 mM capsaicin, skin substance P levels fell to only half the normal value at day 1 and remained at this level throughout the 4 day period examined. 7. It is suggested that the ability of relatively low concentrations of capsaicin to desensitize C-fibre nociceptors may underlie the analgesic action of topical capsaicin in man.
Elastoviscous substances with analgesic effects on joint pain reduce stretch-activated ion channel activity in vitro (2002)

Activation by noxious mechanical stimuli of sensory nerve fibres that signal joint pain takes place through stretch-activated ion channels, which open in response to increased membrane tension. It has been suggested that the analgesic effect of hyaluronan solutions used for intra-articular treatment of joint pain in humans are mediated by a reduction of the sensitivity of mechanosensory ion channels of nociceptive nerve terminals. We have investigated whether cross-linked hyaluronan solutions (hylans) of different elastoviscosities modify the response characteristics of stretch-activated ion channels of Xenopus laevis oocytes. Patch-clamp recordings on intact oocytes and in excised membrane patches (outside-out and inside-out configurations) were performed in Barth's solution (control condition) and after exposure to hylans of different elastoviscosities. For mechanical stimulation, monitored suction was applied through the microelectrode and the activity of stretch-activated channels was recorded. The activity of stretch-activated channels was significantly reduced in the presence of high elastoviscous hylan A (0.8% polymer content, molecular weight 6M) and of a mixture of hylan A (90% by weight) and hylan B (10% by weight), 0.9% total polymer content, a clinically used hylan product. In contrast, solutions of hylan A with the same chemical composition but reduced elastoviscosity (0.8% polymer content, molecular weight 96000) were found ineffective. It is concluded that stretch-activated channels have a decreased mechanical sensitivity in the presence of elastoviscous solutions of hylan, but not in the presence of non-elastoviscous solutions of hylan of the same concentration. These data suggest that the analgesic effects of intra-articular injections of elastoviscous solutions of hylans are due to a reduction of the sensitivity to mechanical forces of stretch-activated channels present in the membrane of joint mechanonociceptors.
Sequence-independent DNA binding and replication initiation by the human origin recognition complex (2003)

We report that a highly purified human origin recognition complex (HsORC) has intrinsic DNA-binding activity, and that this activity is modestly stimulated by ATP. HsORC binds preferentially to synthetic AT-rich polydeoxynucleotides, but does not effectively discriminate between natural DNA fragments that contain known human origins and control fragments. The complex fully restores DNA replication to ORC-depleted Xenopus egg extracts, providing strong evidence for its initiator function. Strikingly, HsORC stimulates initiation from any DNA sequence, and it does not preferentially replicate DNA containing human origin sequences. These data provide a biochemical explanation for the observation that in metazoans, initiation of DNA replication often occurs in a seemingly random pattern, and they have important implications for the nature of human origins of DNA replication.
Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in <i>Xenopus</i> oocytes (1982)

Messenger RNA extracted from the electric organ of Torpedo was injected into Xenopus oocytes. This led to the synthesis and incorporation of functional acetylcholine receptors into the membrane of the oocyte. When activated by acetylcholine these Torpedo acetylcholine receptors in the oocyte membrane opened channels whose ionic permeability resembled that of nicotinic receptors in other cells.
On the theory of planar spectrographs (1992)

The theory of planar spectrographs is presented. It is proven that by no means all aberrations up to the order of x/sup 4/ can be corrected over a finite spectral range. A general procedure to construct gratings with two stigmatic points of (nearly) arbitrary wavelength and location is proposed. Rowland-type and flatfield spectrographs are discussed as numerical examples.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hepatitis B virus genotyping: current methods and clinical implications (2010)

Hepatitis B virus (HBV) is a major cause of liver cirrhosis and hepatocellular carcinoma (HCC). Eight different HBV genotypes have been identified with distinct geographical distributions. Different genotyping methods exist including sequencing, INNO-LiPA, restriction fragment polymorphism (RFLP), multiplex PCR, serotyping, oligonucleotide microarray chips, reverse dot blot, restriction fragment mass polymorphism (RFMP), invader assay, and real-time PCR. Several investigators have studied the influence of HBV genotypes on clinical outcomes in chronic HBV patients. This review describes the current genotyping techniques, as well as their advantages and limitations. It also presents the clinical evidence that correlates HBV genotypes to clinical outcomes including disease severity, HCC development, response to therapy, disease chronicity, transplantation outcomes, and occult infection.
Condensation polymerization of diphenyl 2,2′‐diiodobiphenyl‐4,4′‐dicarboxylate with some di‐ and tetraamino compounds (1980)

Abstract In connection with the research for new thermostable high molecular weight materials several polybenzimidazoles were prepared by condensing diphenyl 2,2′‐diiodobiphenyl‐4,4′‐dicarboxylate ( 1 ) with 3,3′‐diaminobenzidine ( 2 ), bis(3,4‐diaminophenyl) ether, 3,3′,4,4′‐tetraaminobenzophenone, 1,2,5,6‐tetraaminoanthraquinone, and 1,2,4,5‐tetraaminobenzene. Depending on the reaction time and temperature, partial replacement of iodine atoms by phenoxy groups occurred in the polymers. Model compounds were prepared by condensation of ester 1 with o ‐phenylenediamine, 2,3‐diaminopyridine, and 3,4‐diaminopyridine. IR, UV, and 1 H NMR spectra of the model compounds were taken. The high thermostability of the polymers could be shown by thermogravimetry.
Hydraulic Fracturing and Shale Gas Production: Technology, Impacts, and Regulations (2012)

Abstract not provided
Comparison of some mechanical and flow properties of linear and tetrachain branched “monodisperse” polystyrenes (1965)

Abstract The strength and flow properties of narrow distribution polystyrenes have been studied as functions of molecular weight and branching (tetrachain star‐type molecules). Most of the mechanical properties of linear and branched narrow distribution polystyrenes were essentially the same as those for a broad distribution general‐purpose polystyrene. For the narrow distribution linear polymers the value of a given property increased rapidly with molecular weight until ca. M = 1.6 × 10 5 . Thereafter the magnitude of the property increased only slightly for rather large increases in M and asymptotically approached a maximum. The same was true of the branched polymers except that certain properties, e.g., tensile strength, were found to level off in value at higher molecular weights than for the corresponding linear polymers. Studies of apparent melt viscosity, η, made with a capillary rheometer showed that at low shear rates ( \documentclass{article}\pagestyle{empty}\begin{document}$ (\dot \gamma < 10) $\end{document} sec. −1 ), the branched polymers exhibited much lower apparent values of η than linear polymers of the same total molecular weight. At high shear rates ( \documentclass{article}\pagestyle{empty}\begin{document}$ (\dot \gamma \sim 2000) $\end{document} sec. −1 ), this difference essentially disappeared and η approached a constant value independent of \documentclass{article}\pagestyle{empty}\begin{document}$ \dot M(1.5 \times 10^5 - 4.5 \times 10^5) $\end{document} and branching. Melt viscosity data for both the linear and branched narrow distribution polymers when plotted in the form of reduced viscosities versus a function of \documentclass{article}\pagestyle{empty}\begin{document}$ \dot \gamma $\end{document} (as suggested by Bueche) fell upon one master curve.
Antidiabetic and adaptogenic properties of <i>Momordica charantia</i> extract: An experimental and clinical evaluation (1993)

Abstract The hypoglycaemic properties of Mormodica charantia (bitter gourd) water extract was tested on alloxan diabetic rats experimentally. A fall of blood sugar after 3 week's treatment with aqueous extract of fruits of the herb was found to be significant ( p <0.01). The aqueous extract of fruit was more effective in diabetes (fall of blood sugar 54% after 3 week's therapy) than the powder of the dried fruit (fall 25% nonsignificant). Hypoglycaemic effects in diabetic patients were found to be highly significant ( p <0.01) at the end of the trial but were cumulative and gradual, unlike that produced by insulin. Adaptogenic properties are indicated by the delay in the appearance of cataracts, the secondary complications of diabetes and relief in neurological and other common symptoms even before the hypoglycaemia occurred.
Measurement of Total Alkaline Phosphatase Activity in Human Serum (1975)

<P>Abstract copyright UK Data Service and data collection copyright owner.</P>These are a series of surveys containing questions asked of a monthly representative sample of 1000 adults about their financial well-being and expectations by the British Market Research Bureau.
ChemInform Abstract: Octahedral Molecular Sieves: Preparation, Characterization, and Applications. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identification of<i>NTN4, TRA1</i>, and<i>STC2</i>as Prognostic Markers in Breast Cancer in a Screen for Signal Sequence Encoding Proteins (2007)

This article describes the identification of three secreted proteins, NTN4, TRA1, and STC2, as potential novel prognostic markers in breast cancer.
Immune Response to Recombinant Mycobacterial Proteins in Patients with Tuberculosis Infection and Disease (1996)

The capacity of four Mycobacterium tuberculosis recombinant antigens to elicit proliferation and cytokine production by human T cells was evaluated. Proliferative responses of peripheral blood mononuclear cells (PBMC) to all antigens were greater in healthy tuberculin reactors than in pulmonary tuberculosis patients, and proliferative responses of pleural fluid cells were greater than those of PBMC from patients with tuberculous pleuritis. The proliferative responses to the four recombinant antigens were similar in all patient groups, and there was no selective unresponsiveness to any antigen in pulmonary tuberculosis patients. The 38-kDa antigen induced less interferon-gamma than did the 10-, 30-, and 65-kDa antigens, and all four antigens induced similar amounts of interleukin-10. These results suggest that none of the four recombinant antigens are immunodominant, and that the 10-, 30-, and 65-kDa antigens are similar in their capacity to induce a potentially protective Th1-like response.
Demonstration of a dual-depletion-region electroabsorption modulator at 1.55-/spl mu/m wavelength for high-speed and low-driving-voltage performance (2005)

We demonstrate a novel structure of electroabsorption modulator (EAM) at a 1.55-μm wavelength: the dual-depletion-region EAM. After an n/sup +/ delta-doped layer was inserted into the thick intrinsic region (550 nm) of a tradition p-i-n modulator, the tradeoff between driving-voltage and electrical bandwidth performance can be released effectively. This new structure can also release the burden imposed on downscaling the width or length of high-speed EAM with low driving-voltage performance. The microwave and electrical-to-optical measurement of this novel device with traveling-wave electrodes show very convincing results.
Replication in mobile database environments: a client-oriented approach (2004)

In mobile C/S database environments a service for replication is needed to guarantee availability of data also in disconnected mode. We propose a new client-oriented replication service for relational databases. Using these service mobile applications can (re)define replicated data and replication options situation-dependent on demand.
M281, an Anti‐FcRn Antibody: Pharmacodynamics, Pharmacokinetics, and Safety Across the Full Range of IgG Reduction in a First‐in‐Human Study (2018)

M281 is a fully human, anti-neonatal Fc receptor (FcRn) antibody that inhibits FcRn-mediated immunoglobulin G (IgG) recycling to decrease pathogenic IgG while preserving IgG production. A randomized, double-blind, placebo-controlled, first-in-human study with 50 normal healthy volunteers was designed to probe safety and the physiological maximum for reduction of IgG. Intravenous infusion of single ascending doses up to 60 mg/kg induced dose-dependent serum IgG reductions, which were similar across all IgG subclasses. Multiple weekly doses of 15 or 30 mg/kg achieved mean IgG reductions of ≈85% from baseline and maintained IgG reductions ≥75% from baseline for up to 24 days. M281 was well tolerated, with no serious or severe adverse events (AEs), few moderate AEs, and a low incidence of infection-related AEs similar to placebo treatment. The tolerability and consistency of M281 pharmacokinetics and pharmacodynamics support further evaluation of M281 in diseases mediated by pathogenic IgG.
Nano-GLADIATOR: real-time detection of copy number alterations from nanopore sequencing data (2019)

Supplementary data are available at Bioinformatics online.
Obtaining the Correspondence Between Bayesian and Neural Networks (1998)

We present in this paper a novel method for eliciting the conditional probability matrices needed for a Bayesian network with the help of a neural network. We demonstrate how we can obtain a correspondence between the two networks by deriving a closed-form solution so that the outputs of the two networks are similar in the least square error sense, not only when determining the discriminant function, but for the full range of their outputs. For this purpose we take into consideration the probability density functions of the independent variables of the problem when we compute the least square error approximation. Our methodoloy is demonstrated with the help of some real data concerning the problem of risk of desertification assessment for some burned forests in Attica, Greece where the parameters of the Bayesian network constructed for this task are successfully estimated given a neural network trained with a set of data.
Abnormal craniofacial growth and early mandibular osteoarthritis in mice harbouring a mutant type II collagen transgene (1997)

Skull morphology and histology in the heterozygous offspring of a transgenic founder mouse Del1, harbouring 6 copies of deletion mutation in Col2a1 gene, were compared with those in normal siblings. On visual observation and roentgenocephalometric examination the heads of heterozygous Del1 mice were smaller than normal. Histologically the sizes of cartilaginous structures of the cranial base were reduced. Severe defects were seen in the temporomandibular joint as progressive osteoarthritic lesions. These observations elucidate the relationship between the genotype and phenotype and demonstrate that heterozygous Del1 mice are a useful model for studies on a genetic disturbance where 'clinical' manifestations are not evident until adult age.
Effectiveness of methoprene-impregnated baits in the control of Monomorium pharaonis ant populations infesting health establishment and households. (1983)

The use of baits consisting of dried egg yolks and impregnated with 0.5% of methoprene, loosely applied twice within 8-12 days at the rate of 1 g of bait per 3-6 m2 of floor surface area at each application was found to result consequently in a complete eradication of M. pharaonis ant populations in two medium-size health establishments and in one apartment house. Under more favorable conditions in another health establishment the use of methoprene-impregnated baits applied twice at the average dose of 1 g per as many as 46 m2 floor area proved equally effective in ensuring permanent eradication of ants. Providing that all colonies on the premises can be affected by bait a complete eradication of ants can be expected within 100 days after the first application of bait.
Removal of colour and turbidity in pulp and paper mill effluents using polyelectrolytes. (2001)

The present study was undertaken for removal of the colour, turbidity and COD from pulp and paper mill effluents using polyelectrolytes for pollution control and its safe disposal. Based on the pH of effluent and nature of colour imparting substance, suitable polyelectrolytes have been selected and used. A novel method of treating the above effluent with 0.2 ml/L of Rishlyte 80 L for the removal of colour, turbidity and COD has been found to be optimal and techno-economically viable when compared with the conventional method of treatment with alum.
An Easy and Convenient Synthesis of Weinreb Amides and Hydroxamates (2001)

ADVERTISEMENT RETURN TO ISSUEPREVNoteAn Easy and Convenient Synthesis of Weinreb Amides and HydroxamatesLidia De Luca, Giampaolo Giacomelli, and Maurizio TaddeiView Author Information Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy [email protected]Cite this: J. Org. Chem. 2001, 66, 7, 2534–2537Publication Date (Web):March 10, 2001Publication History Received15 January 2001Published online10 March 2001Published inissue 1 April 2001https://pubs.acs.org/doi/10.1021/jo015524bhttps://doi.org/10.1021/jo015524bbrief-reportACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views9480Altmetric-Citations121LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amides,Anions,Mixtures,Organic acids,Reagents Get e-Alerts