gebhart/patrepeval huggingface dataset:
P‐3  Involvement of the accessory gene regulatory (<i>agr</i>) system in quorum sensing by <i>Staphylococcus intermedius</i> (2004)

Toxic exoproteins are believed to be involved in the pathogenesis of Staphylococcus intermedius pyoderma and bacterial overgrowth, although these diseases are poorly understood. This study aims to determine whether quorum sensing, a phenomenon in which cells express particular characteristics only when population densities exceed certain levels, might be involved. Production of virulence factors by S. intermedius was hypothesized to be initiated by the agr system via signalling molecules generated as cell density increased, as in S. aureus . Initial studies ( agr ‐specific PCR, genome walking) confirmed the presence of sequences in S. intermedius related to the agr of S. aureus . To test the hypothesis that expression of RNAIII (effector of the agr system) and two exotoxins, leukotoxin and enterotoxin C, are initiated by an environmental signal generated during bacterial growth, experiments were performed in which spent culture supernatants from different phases of growth were added to early exponential cultures of S. intermedius in which the genes are minimally expressed. Through real‐time quantitative PCR, it was shown that concentrated supernatant of midexponential and postexponential cultures from S. intermedius strains 3 and 27 up‐regulated expression of genes encoding for RNAIII, leukotoxin and enterotoxin in strain 3. This indicates that the activating substance accumulates in supernatant during growth. In contrast, S. intermedius was insensitive to spent medium from S. aureus strain J3964. This suggests that S. intermedius uses quorum sensing to monitor the proximity of other signal‐producing cells and thereby adjusts its expression of virulence genes appropriately to facilitate species‐specific and intraspecies cell‐cell communication. Funding: Nestlé Purina Research Company.
Social analysis : selected tools and techniques (2001)

The AXs from rice have a higher A/X ratio than the AXs from maize, suggesting more branching and a more complex side chain. The structural difference was crucial for the difference in fermentation pattern. Different <i>Bacteroides</i> species are responsible for the utilization of rice AXs and corn AXs. Although feruloylation had a minor effect on the overall fermentation pattern, it significantly affected butyrate production and alpha diversity. dRAX promoted less butyrate than RAX, which is associated with a significantly lower amount of <i>Faecalibacterium prausnitzi</i>. dCAX promoted more butyrate than CAX, which may be associated with a lower amount of <i>Bacteroides ovatus</i> and a higher amount of <i>Blautia</i> in dCAX compared to CAX. The effects of feruloylation on the fermentation pattern and the resulted microbiota shift of AX varied depending on the carbohydrate structure.
Expression and regulation of stromelysin and matrilysin by growth factors and oncogenes (1994)

Conference Article| February 01 1994 Expression and regulation of stromelysin and matrilysin by growth factors and oncogenes Susan McDonnell; Susan McDonnell ‡ *School of Biological Sciences, Dublin City University, Glasnevin, Dublin 11, Ireland ‡To whom correspondence should be addressed. Search for other works by this author on: This Site PubMed Google Scholar Jane H. Wright; Jane H. Wright †Department of Cell Biology, Vanderbilt University, Nashville TN 37232, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Mireille Gaire; Mireille Gaire †Department of Cell Biology, Vanderbilt University, Nashville TN 37232, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Lynn M. Matrisian Lynn M. Matrisian †Department of Cell Biology, Vanderbilt University, Nashville TN 37232, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1994) 22 (1): 58–63. https://doi.org/10.1042/bst0220058 Article history Received: October 06 1993 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Susan McDonnell, Jane H. Wright, Mireille Gaire, Lynn M. Matrisian; Expression and regulation of stromelysin and matrilysin by growth factors and oncogenes. Biochem Soc Trans 1 February 1994; 22 (1): 58–63. doi: https://doi.org/10.1042/bst0220058 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: MMP, matrix metalloproteinase, TIMP, tissue inhibitor of metalloproteinase, DMBA, dimethylbenz[α]anthracene, PMA, phorbol 12-myristate 13-acetate, TRE, TPA responsive element, AP-1, activator protein-1, TIE, TGF-β, inhibitory element, EGF, epidermal growth factor, PEA-3, polyoma enhancer A binding protein-3 This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Airwriting recognition using wearable motion sensors (2010)

In this work we present a wearable input device which enables the user to input text into a computer. The text is written into the air via character gestures, like using an imaginary blackboard. To allow hands-free operation, we designed and implemented a data glove, equipped with three gyroscopes and three accelerometers to measure hand motion. Data is sent wirelessly to the computer via Bluetooth. We use HMMs for character recognition and concatenated character models for word recognition. As features we apply normalized raw sensor signals. Experiments on single character and word recognition are performed to evaluate the end-to-end system. On a character database with 10 writers, we achieve an average writer-dependent character recognition rate of 94.8% and a writer-independent character recognition rate of 81.9%. Based on a small vocabulary of 652 words, we achieve a single-writer word recognition rate of 97.5%, a performance we deem is advisable for many applications. The final system is integrated into an online word recognition demonstration system to showcase its applicability.
Construction of Dual OVSF Codes with Lower Correlations (2006)

In wide-band code division multiple access (WCDMA), orthogonal variable spreading factors (OVSF) codes are assigned to different users to preserve the orthogonality between users' physical channels. In this letter, we present the dual OVSF code, which can transmit the variable data rates by suing two different modulated signals without loss of the orthogonality. The bit error rate (BER) performance under a multi-user environment suffering the additive white Gaussian noise (AWGN) channel and correlations of those codes are evaluated. The results demonstrate that the proposed dual OVSF scheme could provide flexible rates and lower correlation values with a slight increase in complexity.
Temperature-aware scheduling and assignment for hard real-time applications on MPSoCs (2008)

Thermal effects in MPSoCs may cause the violation of timing constraints in real-time systems. This paper presents a mixed integer linear programming based solution to this problem. Tasks are assigned and scheduled to an MPSoC to minimize peak temperature, subject to real-time constraints. The proposed approach outperforms existing methods, reducing peak temperature by up to 24.66°C and by an average of 8.75°C when compared to minimal-energy solutions. We also present a heuristic for use on large problem instances. Steady-state thermal analysis is used for tasks with long execution times compared to the RC thermal time constants of the cores. Transient analysis is used otherwise. The steady-state analysis based heuristic finds solutions with at most 3.40°C deviation from optimal peak temperature (0.22°C on average) while improving upon existing technique by as much as 25.71°C and 10.86°C on average. The transient analysis based heuristic further reduce peak temperature by 1°C in the best case and 0.17°C on average.
Do all ionic liquids need organic cations? Characterisation of [AlCl2·nAmide]+ AlCl4− and comparison with imidazolium based systems (2011)

The addition of a simple amide to AlCl(3) causes the formation of a liquid of the form [AlCl(2)·nAmide](+) AlCl(4)(-). The material thus produced is liquid over a wide temperature range, is relatively insensitive to water and has the properties of an ionic liquid. This ionic liquid is shown to be a suitable medium for the acetylation of ferrocene and the electrodeposition of aluminium and demonstrated that quaternary ammonium cations are not always needed to form ionic liquids.
2,4-Dienoyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation. (1990)

Several inherited disorders of fatty acid beta-oxidation have been described that relate mainly to saturated precursors. This study is the first report of an enzyme defect related only to unsaturated fatty acid oxidation and provides the first in vivo evidence that fat oxidation in humans proceeds by the reductase-dependent pathway. The patient was a black female, presenting in the neonatal period with persistent hypotonia. Biochemical studies revealed hyperlysinemia, hypocarnitinemia, normal organic acid profile, and an unusual acylcarnitine species in both urine and blood. The new metabolite was positively identified by mass spectrometry as 2-trans,4-cis-decadienoylcarnitine, derived from incomplete oxidation of linoleic acid. In spite of dietary therapy, the patient died of respiratory acidosis at four months of age. Samples of liver and muscle from the autopsy were assayed for 2,4-dienoyl-coenzyme A reductase activity. Using the substrate 2-trans,4-cis-decadienoylcoenzyme A, the reductase activity was 40% of the control value in liver and only 17% of that found in normal muscle. It is suggested that unsaturated substrates should be used for in vitro testing to cover the full range of potential beta-oxidation defects and that acylcarnitine species identification be used for in vivo detection of this disorder.
Mechanisms of sepsis-induced organ dysfunction (2007)

Current understanding of the pathophysiology underlying sepsis-induced multiple organ dysfunction highlights the multiple cell populations and cell-signaling pathways involved in this complex condition. There is an increasing appreciation of interactions existing between different cells and organs affected by the septic process. The intricate cross-talk provided by temporal changes in mediators, hormones, metabolites, neural signaling, alterations in oxygen delivery and utilization, and by modifications in cell phenotypes underlines the adaptive and even coordinated processes beyond the dysregulated chaos in which sepsis was once perceived. Many pathologic processes previously considered to be detrimental are now viewed as potentially protective. Applying systems approaches to these complex processes will permit better appreciation of the effectiveness or harm of treatments, both present and future, and also will allow development not only of better directed, but also of more appropriately timed, strategies to improve outcomes from this still highly lethal condition.
A perspective on inductive databases (2002)

Inductive databases tightly integrate databases with data mining. The key ideas are that data and patterns (or models) are handled in the same way and that an inductive query language allows the user to query and manipulate the patterns (or models) of interest.This paper proposes a simple and abstract model for inductive databases. We describe the basic formalism, a simple but fairly powerful inductive query language, some basics of reasoning for query optimization, and discuss some memory organization and implementation issues.
A plasmonic fluid with dynamically tunable optical properties (2009)

We report the first synthesis of a gold nanorod (GNR)-based nanocomposite that exhibits solid-like plasmonic properties while behaving in a liquid-like manner. Tuning the degree of GNR clustering controls the material's responsiveness to external stimuli, such as mechanical shearing, due to the sensitivity of the localized surface plasmon resonance to interparticle interactions.
Barack Obama et le “rêve américain” (2009)

est autorise que dans les limites des conditions gnrales d'utilisation du site ou, le cas chant, des conditions gnrales de la licence souscrite par votre tablissement.
A Second Domesday? (2004)

The 1279–80 hundred rolls are one of the most important but neglected sources for 13th-century English history. This book places the inquiry in its historical context among other inquiries by Edward I in England, Gascony, the Channel Islands, and Wales, and by other rulers on the Continent. It examines its purpose and whether it was conceived deliberately as a second Domesday Book. The geographical range and chronology of the inquiry are examined, how it was conducted and the way in which the returns were compiled. The book concludes with an assessment of the uses which contemporaries and modern historians have made of the returns. There are appendices providing lists of the manuscripts and printed editions of all known surviving rolls, the commission of inquiry and oath taken by commissioners and the articles of inquiry for Cambridgeshire and London.
Spectral Adiabatic Inversion Recovery (SPAIR) MR imaging of the Abdomen (2008)

Background Magnetic resonance imaging (MRI) has become a major imaging tool for the depiction and characterization of abdominal disease. Standard abdominal MRI protocols encompass different forms of T1-weighted (T1w) and T2-weighted (T2w) data acquisition. These sequences can be collected in less than 20 seconds, which typically is within the patients’ ability to suspend respiration. Hence, artifacts due to physiological motion including respiration and bowel motion can be reduced, if not avoided. While most T1-weighted imaging techniques of the abdomen include gradient echo (GRE)
Mapping Proppant Distribution in Hydraulic Fractures in Cased Wellbores Using Low Frequency Downhole Electrical Measurements (2018)

Abstract A tool concept using downhole electrical measurements for mapping electrically conductive proppant in hydraulic fractures is presented in this paper. The method relies on direct excitation of the casing, which overcomes the severe limitations of induction tools in cased wellbores. An array of insulating gaps is installed and cemented in place as a permanent part of the casing string. The electrical measurements are done by imposing a voltage across each insulating gap, one at a time, before and after hydraulic fracture operations. The voltages across other insulating gaps near the transmitter gap are recorded. The proposed tool's response to the geometry of a single fracture was modeled by solving for the electrical potential using a finite volume method. Preliminary results have shown that the electrically conductive proppant alters the path of the electrical current in the formation and this is recorded as differential signals by the string of insulating gaps surrounding the source gap. The measured differential signals are highly sensitive to a fracture's location, size, and orientation, and less sensitive to the fracture shape. However, to enable the implementation of such a practical system, various aspects of the tool need to be further investigated. Following our previous work, this paper focuses on forward modeling of the tool's response to multiple fractures, which demonstrates the influence of these fractures to the signals and provides important guidance for inverse modeling. Parametric inversion of fractures from synthetic data, generated by exciting various insulating gaps, is solved by using Very Fast Simulated Annealing (VFSA). Simulation results show that when multiple hydraulic fractures are present, the voltages measured at the receiver gaps are primarily determined by the geometry of the fracture, which is in direct contact with the excited section of casing. When two fractures touch the same casing section, they induce very similar voltages to those from a single fracture with equivalent conductance. Preliminary inversion results from synthetic data indicate that the proposed VFSA can solve for the multiple fractures' conductance and size at the same time, without requiring a large number of forward simulations. Even with noisy synthetic data, VFSA is able to make good estimates of the fractures' geometries. This indicates that the VFSA technique is a proper and robust inversion technique for the measured voltages at various receiver gaps.
Synthèse de nouvelles tryptamines substituées (1966)

Abstract 1° Les esters des acides indolyl‐3‐acétiques sont obtenus avec de bons rendements à l'aide de résine sulfonique Dowex comme catalyseur d'estérification.
Experimental hypothermia and cold perception. (1989)

Twelve subjects clothed in flotation suits were immersed in 10 degrees C cold water and their surface temperatures at the back and groin, as well as core temperatures, were continuously monitored. Subjects were unable to reliably assess how cold they were, with the highest correlation observed between perceived temperature and actual temperature reaching only 0.51. This was felt to be partially due to the uneven distribution of surface temperatures seen in this experiment and in most cold water immersions. Rapid cooling in cold water also produced the perceptual phenomenon of "overshooting" previously observed in cold air studies, characterized by sudden temperature drops being perceived as cold sensations of greater magnitude. The results suggest that subjects who are rapidly cooled in water may have considerable difficulty separating feelings of cold from feelings of pain and discomfort, which can have serious implications in survival situations and highlights the subjective and highly variable nature of cold perception. Perceived cold sensation may be a very poor, and possibly dangerous, predictor in cold water immersion situations.
Physicochemical characterization of a reverse micellar solution after loading with different drugs. (2000)

Diclofenac sodium (DS), timolol maleate (TM) and pilocarpine hydrochloride (PHCl) were solubilized in a reverse micellar solution (RMS) consisting of lecithin and middle-chain triglycerides (MCT). The influence of these drugs on the physicochemical parameters of the RMS was investigated. Although none of the drugs influenced the size of the associates, the micellar shapes varied considerably. While DS and PHCl increased the anisometry, reverse micelles with TM were spherical. The transformation of the RMS into a lamellar mesophase on contact with water was generally not prevented by any of the drugs but all drugs led to an increased number of defect structures in the liquid crystal. Furthermore the interlayer distance of the lamellar mesophase was reduced by a higher content of DS. In comparison with an RMS containing isopropylmyristate (IPM) instead of MCT, differences in the physicochemical properties of the drug-free RMS and in the influences of solubilized drugs were noticed.
DNA-Directed Coupling of Organic Modules by Multiple Parallel Reductive Aminations and Subsequent Cleavage of Selected DNA Sequences (2005)

A new method for DNA-directed assembly of organic modules by multiple parallel reductive aminations is presented. Linear oligonucleotide-functionalized modules (LOMs) consist of a rigid oligo(phenylene ethynylene) backbone with two salicylaldehyde termini, and each terminus is conjugated with an oligonucleotide sequence. The stability of the tetrahydrosalen-linked modules toward elevated temperature, low pH, nucleophiles, and metal chelators is studied and compared to the analogous metal-salen-linked modules. A linear oligonucleotide-functionalized disulfide-linked module (LOSM) containing cleavable linkers between the organic module and the two DNA sequences is coupled by DNA-directed reductive aminations to non-modified LOM modules. This enables selective cleavage of the DNA strands of a central module in a structure consisting of three modules, and the reactions are analyzed by electrophoresis and 32P-labeling of one of the DNA sequences of the central LOSM.
The History of the Darcy-Weisbach Equation for Pipe Flow Resistance (2002)

The historical development of the Darcy-Weisbach equation for pipe flow resistance is examined. A concise examination of the evolution of the equation itself and the Darcy friction factor is presented from their inception to the present day. The contributions of Chézy, Weisbach, Darcy, Poiseuille, Hagen, Prandtl, Blasius, von Kármán, Nikuradse, Colebrook, White, Rouse and Moody are described.
Myosin Specific-T Lymphocytes Mediated Myocardial Inflammation in Adoptive Transferred Rats (2006)

肌浆球蛋白 specific-T 淋巴细胞可能调停心肌的发炎并且在 AMI 以后改变。在 vitro 的 Myosinactivated 或 unactivated T 淋巴细胞分别地被变成中间广场 syngeneic 老鼠。T 淋巴细胞渗入和 myocyte apoptosis 被 H&E 和隧道探索。蛋白质和在心肌层的 cytokines (IL-1， IL-6 和 TNF-) 的 mRNA 层次被 RT-PCR 和 immunohistochemistry 决定。T 淋巴细胞渗入显然在一星期激活的 T 房间转移以后被观察。cytokines 的表情一个星期以后显著地被提高。myocyte apoptosis 在心肌层发生在 T 淋巴细胞渗入以后。我们的调查结果建议心脏的肌浆球蛋白 activated-T 淋巴细胞可以调停心肌的发炎并且改变。
The Effect of Bonded Ligand Structure on Solute Retention in Reversed-Phase High Performance Liquid Chromatography (1981)

A comparison of the chromatographic retention characteristics of nonpolar bonded stationary phases that offer a systematic change in bonded ligand geometry was undertaken. The study permits an evaluation of the influence of bonded ligand structure on stationary phase contributions to selectivity in reversed-phase systems. It was found that an n-heptyl bonded phase proved superior in terms of capacity and selectivity to bonded cyclohexyl and bicycloheptyl systems. The cyclohexyl phase, however, displayed significant differential preferability for cyclic hydrocarbon solutes as compared to linear alkane solutes.
Increased Expression of the Autocrine Motility Factor is Associated With Poor Prognosis in Patients With Clear Cell–Renal Cell Carcinoma (2015)

Glucose-6-phosphate isomerase (GPI), also known as phosphoglucose isomerase, was initially identified as the second glycolytic enzyme that catalyzes the interconversion of glucose-6-phosphate to fructose-6-phosphate. Later studies demonstrated that GPI was the same as the autocrine motility factor (AMF), and that it mediates its biological effects through the interaction with its surface receptor (AMFR/gp78). In this study, we assessed the role of GPI/AMF as a prognostic factor for clear cell renal cell carcinoma (ccRCC) cancer-specific (CSS) and progression-free survival (PFS). In addition, we evaluated the expression and localization of GPI/AMF and AMFR, using tissue microarray-based immunohistochemistry (TMA-IHC), indirect immunofluorescence (IF), and confocal microscopy analysis.Primary renal tumor and nonneoplastic tissues were collected from 180 patients who underwent nephrectomy for ccRCC. TMA-IHC and IF staining showed an increased signal for both GPI and AMFR in cancer cells, and their colocalization on plasma membrane. Kaplan-Meier curves showed significant differences in CSS and PFS among groups of patients with high versus low GPI expression. In particular, patients with high tissue levels of GPI had a 5-year survival rate of 58.8%, as compared to 92.1% for subjects with low levels (P < 0.0001). Similar findings were observed for PFS (56.8% vs 93.3% at 5 years). At multivariate analysis, GPI was an independent adverse prognostic factor for CSS (HR = 1.26; P = 0.001), and PFS (HR = 1.16; P = 0.01).In conclusion, our data suggest that GPI could serve as a marker of ccRCC aggressiveness and a prognostic factor for CSS and PFS.