gebhart/patrepeval huggingface dataset:
Myocardial ischemia, stunning, inflammation, and apoptosis during cardiac surgery: a review of evidence (2004)

Cardiac surgery (CS), in particular cardiopulmonary bypass and cardioplegia, have been reported to trigger myocardial inflammation and apoptosis. This surgery-related inflammatory reaction appears to be of extreme complexity with regard to its molecular, cellular and tissue mechanisms. Both experimental and clinical studies have ascertained the role of several hormonal mediators, mitochondria, cardioplegia and extracorporeal circulation temperature, apoptosis and even genetic modulators of damage. However, the correlations between these factors in vivo and post-surgery outcome and prognosis have not yet been systematically investigated. In animal models of myocardial cardioplegia and/or ischemia-reperfusion, experimental drugs such as antioxidants have been documented to provide amelioration of post-intervention cardiac performance and reduction of apoptosis suggesting the possibility of new therapeutic strategies. However, these findings have been only partially confirmed in humans. Moreover, markers for the differential detection of early and late phases of apoptosis are subjects of intense investigations. This review will provide an overview of the major studies about the link between ischemia, myocardial inflammation and apoptosis during and after CS, with particular regard to the markers and methods for apoptosis detection.
Extreme Classification in Log Memory (2018)

We present Merged-Averaged Classifiers via Hashing (MACH) for K-classification with ultra-large values of K. Compared to traditional one-vs-all classifiers that require O(Kd) memory and inference cost, MACH only need O(d log K) (d is dimensionality )memory while only requiring O(K log K + d log K) operation for inference. MACH is a generic K-classification algorithm, with provably theoretical guarantees, which requires O(log K) memory without any assumption on the relationship between classes. MACH uses universal hashing to reduce classification with a large number of classes to few independent classification tasks with small (constant) number of classes. We provide theoretical quantification of discriminability-memory tradeoff. With MACH we can train ODP dataset with 100,000 classes and 400,000 features on a single Titan X GPU, with the classification accuracy of 19.28%, which is the best-reported accuracy on this dataset. Before this work, the best performing baseline is a one-vs-all classifier that requires 40 billion parameters (160 GB model size) and achieves 9% accuracy. In contrast, MACH can achieve 9% accuracy with 480x reduction in the model size (of mere 0.3GB). With MACH, we also demonstrate complete training of fine-grained imagenet dataset (compressed size 104GB), with 21,000 classes, on a single GPU. To the best of our knowledge, this is the first work to demonstrate complete training of these extreme-class datasets on a single Titan X.
Using Electrical Stimulation to Enhance the Efficacy of Cell Transplantation Therapies for Neurodegenerative Retinal Diseases: Concepts, Challenges, and Future Perspectives (2017)

Disease or trauma-induced loss or dysfunction of neurons in any central nervous system (CNS) tissue will have a significant impact on the health of the affected patient. The retina is a multilayered tissue that originates from the neuroectoderm, much like the brain and spinal cord. While sight is not required for life, neurodegeneration-related loss of vision not only affects the quality of life for the patient but also has societal implications in terms of health care expenditure. Thus, it is essential to develop effective strategies to repair the retina and prevent disease symptoms. To address this need, multiple techniques have been investigated for their efficacy in treating retinal degeneration. Recent advances in cell transplantation (CT) techniques in preclinical, animal, and in vitro culture studies, including further evaluation of endogenous retinal stem cells and the differentiation of exogenous adult stem cells into various retinal cell types, suggest that this may be the most appropriate option to replace lost retinal neurons. Unfortunately, the various limitations of CT, such as immune rejection or aberrant cell behavior, have largely prevented this technique from becoming a widely used clinical treatment option. In parallel with the advances in CT methodology, the use of electrical stimulation (ES) to treat retinal degeneration has also been recently evaluated with promising results. In this review, we propose that ES could be used to enhance CT therapy, whereby electrical impulses can be applied to the retina to control both native and transplanted stem cell behavior/survival in order to circumvent the limitations associated with retinal CT. To highlight the benefits of this dual treatment, we have briefly outlined the recent developments and limitations of CT with regard to its use in the ocular environment, followed by a brief description of retinal ES, as well as described their combined use in other CNS tissues.
Democratic Centralism: A Hybrid Blockchain Architecture and Its Applications in Energy Internet (2017)

Blockchain is attracting more and more attentions from many kinds of fields, such as finance, industry, and theory researchers. Rather than viewing blockchain as a novel technology, we should think it as an innovation for managing digital society, which provides fundamental principles to support democratically distributed applications. Based on the design and application of the Energy Internet, this paper analyzes the core architecture of the initial blockchain technology, and combines the security of the public chain with the efficiency of the private chain, solving the poor efficiency problem of the initial blockchain by using the high efficiency of private chain. At the same time, it inherits the security and non-tampering of initial blockchain. This paper designs a new hybrid blockchain storaging mode that is Block Static Storage(BSS, internal structure is N+X hybrid blockchain, following can be referred to as N+X HBC),for purpose that improving the overall efficiency of the Internet running, achieving decentralized supervision, and provoding a credible, safe and efficient performance of the Energy Internet in the storage of its massive data, as well as a huge business system.
Emerging technologies for WLAN (2015)

New technologies continue to be introduced for WLAN applications at a robust pace. We review the value proposition for some of the key features of 802.11ac such as larger bandwidth, higher order modulation, and MIMO and MUMIMO transmission modes, explaining how each feature translates to improved user experience. We present channel measurements and prototype performance data to demonstrate the gains of MIMO and MU-MIMO in an indoor environment. Next, we discuss the value proposition of some key features of 802.11ah. Measurement data of 802.11ah performance is provided, showing how it is a compelling technology for the growing Internet of Things market. We conclude with a preview of emerging technologies that promise to improve user experience - 802.11ai for fast network acquisition and 802.11ax for high-efficiency networking in dense indoor and outdoor networks.
Spin-Electricity Conversion Induced by Spin Injection into Topological Insulators (2014)

We report successful spin injection into the surface states of topological insulators by using a spin pumping technique. By measuring the voltage that shows up across the samples as a result of spin pumping, we demonstrate that a spin-electricity conversion effect takes place in the surface states of bulk-insulating topological insulators Bi(1.5)Sb(0.5)Te(1.7)Se(1.3) and Sn-doped Bi(2)Te(2)Se. In this process, the injected spins are converted into a charge current along the Hall direction due to the spin-momentum locking on the surface state.
Image Retrieval and Re-Ranking Techniques - A Survey (2014)

There is a huge amount of research work focusing on the searching, retrieval and re-ranking of images in the image database. The diverse and scattered work in this domain needs to be collected and organized for easy and quick reference.
Measurement of the Optical Properties of Apples by Hyperspectral Imaging for Assessing Fruit Quality (2006)

Absorption and reduced scattering coefficients are two fundamental optical properties forturbid materials. The objective of this research was to use a newly developed hyperspectral imagingtechnique for determining the absorption and reduced scattering coefficients of apples and to relatethem to fruit firmness and soluble solids content. Hyperspectral images were acquired from 650Golden Delicious apples. The absorption and reduced scattering coefficients of the apples weredetermined using an inverse algorithm to fit the diffusion theory model to individual scattering profilesover the wavelengths of 530-950 nm. Values of the absorption and reduced scattering coefficientswere in the range of 0.0-0.3 cm-1 and 11- 19 cm-1, respectively. For most apples, there was apredominant peak around 675 nm due to chlorophyll absorption. Spectra of the reduced scatteringcoefficient decreased monotonically with the increasing wavelength. Both absorption and reducedscattering coefficients were correlated with fruit firmness, with the correlation coefficient of 0.56-0.66.Poor correlation between fruit soluble solids content and the absorption coefficient was obtained,which could be due to relatively high fitting errors for the absorption coefficient. Improvements inhardware and computational algorithm are needed for more accurate, reliable measurements of theoptical properties of food and agricultural products.
Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells (2008)

Oxidative stress and inflammation are implicated in the pathogenesis of many age-related diseases. Stress-induced overproduction of inflammatory cytokines, such as interleukin-8 (IL-8), is one of the early events of inflammation. The objective of this study was to elucidate mechanistic links between oxidative stress and overproduction of IL-8 in retinal pigment epithelial (RPE) cells. We found that exposure of RPE cells to H(2)O(2), paraquat, or A2E-mediated photooxidation resulted in increased expression and secretion of IL-8. All of these oxidative stressors also inactivated the proteasome in RPE cells. In contrast, tert-butylhydroperoxide (TBH), a lipophilic oxidant that did not stimulate IL-8 production, also did not inactivate the proteasome. Moreover, prolonged treatment of RPE cells with proteasome-specific inhibitors recapitulated the stimulation of IL-8 production. These data suggest that oxidative inactivation of the proteasome is a potential mechanistic link between oxidative stress and up-regulation of the proinflammatory IL-8. The downstream signaling pathways that govern the production of IL-8 include NF-kappaB and p38 MAPK. Proteasome inhibition both attenuated the activation and delayed the turnoff of NF-kappaB, resulting in biphasic effects on the production of IL-8. Prolonged proteasome inhibition (>2 h) resulted in activation of p38 MAPK via activation of MKK3/6 and increased the production of IL-8. Chemically inhibiting the p38 MAPK blocked the proteasome inhibition-induced up-regulation of IL-8. Together, these data indicate that oxidative inactivation of the proteasome and the related activation of the p38 MAPK pathway provide a potential link between oxidative stress and overproduction of proinflammatory cytokines, such as IL-8.
Immunoglobulin Analysis Tool: A Novel Tool for the Analysis of Human and Mouse Heavy and Light Chain Transcripts (2012)

Sequence analysis of immunoglobulin (Ig) heavy and light chain transcripts can refine categorization of B cell subpopulations and can shed light on the selective forces that act during immune responses or immune dysregulation, such as autoimmunity, allergy, and B cell malignancy. High-throughput sequencing yields Ig transcript collections of unprecedented size. The authoritative web-based IMGT/HighV-QUEST program is capable of analyzing large collections of transcripts and provides annotated output files to describe many key properties of Ig transcripts. However, additional processing of these flat files is required to create figures, or to facilitate analysis of additional features and comparisons between sequence sets. We present an easy-to-use Microsoft(®) Excel(®) based software, named Immunoglobulin Analysis Tool (IgAT), for the summary, interrogation, and further processing of IMGT/HighV-QUEST output files. IgAT generates descriptive statistics and high-quality figures for collections of murine or human Ig heavy or light chain transcripts ranging from 1 to 150,000 sequences. In addition to traditionally studied properties of Ig transcripts - such as the usage of germline gene segments, or the length and composition of the CDR-3 region - IgAT also uses published algorithms to calculate the probability of antigen selection based on somatic mutational patterns, the average hydrophobicity of the antigen-binding sites, and predictable structural properties of the CDR-H3 loop according to Shirai's H3-rules. These refined analyses provide in-depth information about the selective forces acting upon Ig repertoires and allow the statistical and graphical comparison of two or more sequence sets. IgAT is easy to use on any computer running Excel(®) 2003 or higher. Thus, IgAT is a useful tool to gain insights into the selective forces and functional properties of small to extremely large collections of Ig transcripts, thereby assisting a researcher to mine a data set to its fullest.
Effects of Fentanyl on Respiratory Pressure‐Volume Relationship in Supine Anesthetized Children (1981)

The effects of fentanyl on total respiratory pressure-volume relationship were studied in 12 supine, anesthetized (thiopental, succinylcholine, halothane, N2O/O2) children, 5, 10 and 15 min after administration of fentanyl, 3 micrograms/kg (Group F) and at similar intervals in 11 control, anesthetized children who did not receive fentanyl (Group C). Lung and chest wall pressure-volume relationships were measured in five children from Group F and in six from Group C. Compliance values were estimated from the linear part of PVR curves. In Group F, a significant decrease was observed at 5, 10 and 15 min (maximum 29%) for total compliance and at 15 min (maximum 26%) for lung compliance. Chest wall compliance was reduced (maximum 45%) at 15 min, but not significantly. In Group C, no change in compliances was noted. The comparison between the two groups for total, chest wall and lung compliances showed a significant decrease in these three parameters at 15 min in children receiving fentanyl. The decrease of chest wall compliance can be explained by increased muscle tone, but the mechanism of decreased lung compliance awaits further study.
GABA<sub>A</sub>Receptor Pharmacology and Subtype mRNA Expression in Human Neuronal NT2-N Cells (1998)

Human NT2 teratocarcinoma cells differentiate into neuron-like NT2-N cells when treated with retinoic acid. GABA evoked concentration-dependent whole-cell currents in NT2-N cells with an EC50 of 21.8 microM and a Hill slope of 1.2. GABAA receptor (GABAR) currents reversed at ECl- and did not display voltage-dependent rectification. GABAR single channels opened in bursts to a 23 pS main conductance level and a 19 pS subconductance level, with infrequent openings to a 27 pS conductance level. Kinetic properties of the main conductance level were similar to other native and recombinant GABAR channels. Diazepam and zolpidem enhanced GABAR currents with moderate affinity, whereas methyl-6, 7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate inhibited GABAR currents. Loreclezole enhanced GABAR currents with high affinity, but furosemide antagonized GABAR currents with low affinity. The neurosteroids alphaxalone and pregnenolone sulfate appropriately modulated GABAR currents. Zinc blocked GABAR currents with low affinity, but lanthanum did not significantly alter NT2-N GABAR currents. Reverse transcription PCR (RT-PCR) performed on RNA from NT2-N cells clearly detected transcripts encoding human alpha2, alpha3, alpha5, beta3, gamma3, and pi subtypes. The combined pharmacological and RT-PCR results are most consistent with a single or predominant GABAR isoform composed of an alpha2 and/or alpha3 subtype combined with the beta3 and gamma3 subtypes. The data do not rule out receptors containing combinations of alpha2 and/or alpha3 subtypes with the alpha5 subtype or receptors with both beta1 and beta3 subtypes. The presence or absence or the pi subunit in functionally expressed receptors could not be determined.
Regulation of the hemA gene during 5-aminolevulinic acid formation in Pseudomonas aeruginosa (1995)

The general tetrapyrrole precursor 5-aminolevulinic acid is formed in bacteria via two different biosynthetic pathways. Members of the alpha group of the proteobacteria use 5-aminolevulinic acid synthase for the condensation of succinyl-coenzyme A and glycine, while other bacteria utilize a two-step pathway from aminoacylated tRNA(Glu). The tRNA-dependent pathway, involving the enzymes glutamyl-tRNA reductase (encoded by hemA) and glutamate-1-semialdehyde-2,1-aminomutase (encoded by hemL), was demonstrated to be used by Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas stutzeri, Comamonas testosteroni, Azotobacter vinelandii, and Acinetobacter calcoaceticus. To study the regulation of the pathway, the glutamyl-tRNA reductase gene (hemA) from P. aeruginosa was cloned by complementation of an Escherichia coli hemA mutant. The hemA gene was mapped to the SpeI A fragment and the DpnIL fragment of the P. aeruginosa chromosome corresponding to min 24.1 to 26.8. The cloned hemA gene, coding for a protein of 423 amino acids with a calculated molecular mass of 46,234 Da, forms an operon with the gene for protein release factor 1 (prf1). This translational factor mediates the termination of the protein chain at the ribosome at amber and ochre codons. Since the cloned hemA gene did not possess one of the appropriate stop codons, an autoregulatory mechanism such as that postulated for the enterobacterial system was ruled out. Three open reading frames of unknown function transcribed in the opposite direction to the hemA gene were found. hemM/orf1 and orf2 were found to be homologous to open reading frames located in the 5' region of enterobacterial hemA genes. Utilization of both transcription start sites was changed in a P. aeruginosa mutant missing the oxygen regulator Anr (Fnr analog), indicating the involvement of the transcription factor in hemA expression. DNA sequences homologous to one half of an Anr binding site were detected at one of the determined transcription start sites.
Weight Lifting in Women with Breast-Cancer–Related Lymphedema (2009)

In breast-cancer survivors with lymphedema, slowly progressive weight lifting had no significant effect on limb swelling and resulted in a decreased incidence of exacerbations of lymphedema, reduced symptoms, and increased strength. (ClinicalTrials.gov number, NCT00194363.)
Review Paper: Efficient numerical methods for the solution of stiff initial-value problems and differential algebraic equations (2003)

In recent years, after a prolonged period of intense activity, the study of numerical methods for solving stiff initial-value problems for ordinary differential equations and differential algebraic equations has reached a certain maturity. There now exist some excellent codes which are both efficient and reliable for solving these particular classes of problems. In this paper, we sketch some of the main theory which underpins stiff integration methods and we use this to describe, and put into context, some of the best codes currently available. By referencing only codes which have been thoroughly tested and are widely available, our aim is to direct users of numerical software to those codes which they should try initially if faced with the problem of solving ordinary differential equations of this type. An additional feature is that the codes which we propose serve as benchmarks against which any new codes can be evaluated.
Immunopathogenesis of Atherosclerosis (2001)

Nonspecific stimulation of the innate immune system accelerates cholesterol-induced atherosclerosis. These data support the concept that atherosclerosis has an immunopathological component and render it improbable that a single infectious agent should assume particular importance in its initiation or progression.
Recommendation for pair-wise key establishment schemes using discrete logarithm cryptography (2009)

This Recommendation specifies key establishment schemes using integer factorization cryptography, based on ANS X9.44, Key Establishment using
High‐Power Density Piezoelectric Energy Harvesting Using Radially Strained Ultrathin Trigonal Tellurium Nanowire Assembly (2013)

A high-yield solution-processed ultrathin (<10 nm) trigonal tellurium (t-Te) nanowire (NW) is introduced as a new class of piezoelectric nanomaterial with a six-fold higher piezoelectric constant compared to conventional ZnO NWs for a high-volume power-density nanogenerator (NG). While determining the energy-harvesting principle in a NG consisting of t-Te NW, it is theoretically and experimentally found that t-Te NW is piezoelectrically activated only by creating strain in its radial direction, along which it has an asymmetric crystal structure. Based upon this mechanism, a NG with a monolayer consisting of well-aligned t-Te NWs and a power density of 9 mW/cm(3) is fabricated.
Gender Differences in Adolescent Attitudes and Receptivity to Sexual Abstinence Education (2005)

This article reports on a study conducted to assess the effect of gender on pre- and postintervention attitudes about sexual abstinence after an abstinence education intervention. Gender had a statistically significant effect on the pretest response for each item. Gender had a statistically significant effect on the posttest response for most of the items. Gender had no effect on items related to the negative impact on future endeavors of having sex and having children. Overall, boys entered the program with stronger attitudes against abstinence than did girls but demonstrated more change toward pro-abstinence beliefs after the intervention. In conclusion, the authors suggest the creation of gender-specific health promotion modules and further research on the efficacy of these modules.
Base-promoted silver-catalyzed protodeboronation of arylboronic acids and esters (2015)

The first base-promoted silver-catalyzed efficient protodeboronation of arylboronic acids and esters in aqueous media was developed.
A System-on-Chip Crystal-Less Wireless Sub-GHz Transmitter (2017)

This paper presents a fully integrated system-onchip wireless transmitter that has no need for an external quartz crystal frequency reference. Instead, a nontrimmable LC oscillator (LCO) is implemented, operating at a fixed frequency of roughly 3.2 GHz. This LCO serves as the accurate frequency reference of the transmitter and is used to derive a frequency in the sub-GHz range for wireless applications via a fractional phase-locked loop. The digital functionality required for the frequency generation and thus for the wireless operation is performed by an 8-b microcontroller. The calibration data as well as the application specific firmware are stored in an integrated EEPROM. An initial frequency accuracy of ±52 ppm over a temperature of -20 °C to 85 °C is achieved using only two temperature insertions for the calibration. The device covers a continuous frequency range of 10-960 MHz and provides an ASK and GFSK operation. A low harmonic power amplifier was implemented to overcome design issues due to injection modulation effects. The chip is implemented in a 130 nm standard CMOS process and constitutes a new approach for a fully integrated wireless sub-GHz transmitter that is competitive to state-of-the-art quartz crystal-based transmitters as well as to already existing crystal-less architectures.