gebhart/patrepeval huggingface dataset:
Finding Needle in a Million Metrics: Anomaly Detection in a Large-scale Computational Advertising Platform (2016)

Online media offers opportunities to marketers to deliver brand messages to a large audience. Advertising technology platforms enables the advertisers to find the proper group of audiences and deliver ad impressions to them in real time. The recent growth of the real time bidding has posed a significant challenge on monitoring such a complicated system. With so many components we need a reliable system that detects the possible changes in the system and alerts the engineering team. In this paper we describe the mechanism that we invented for recovering the representative metrics and detecting the change in their behavior. We show that this mechanism is able to detect the possible problems in time by describing some incident cases.
USDA's 1998 Ethanol Cost-of-Production Survey (2002)

In 2003, the U.S. Department of Agriculture surveyed 21 dry-mill ethanol plants to estimate their 2002 production costs, including both variable (feedstock and plant operation) and capital expenses. These plants produced about 550 million gallons of ethanol in 2002. Net feedstock costs for the surveyed plants ranged from 39 to 68 cents per gallon in 2002. For cash operating expenses, the average energy expenditure was 17.29 cents per gallon. Labor costs ranged from 3 to 11 cents per gallon, maintenance costs from 1 to 7 cents, and administrative costs from 1 to 18 cents. For capital expenditures, new plant construction costs from $1.05 to $3.00 per gallon of ethanol. Average investment to expand existing ethanol production capacity was 50 cents per gallon; hence, expansion tends to cost less than new capacity. Comparison with a 1998 survey of ethanol producers showed that total operating costs in 2002 had changed very little from 1998. It also showed that the average cost of building new plants had dropped, possibly due to designs that emphasize economies of scale.
Femtosecond laser induced surface swelling in poly-methyl methacrylate (2013)

We show that surface swelling is the first step in the interaction of a single femtosecond laser pulse with PMMA. This is followed by perforation of the swollen structure and material ejection. The size of the swelling and the perforated hole increases with pulse energy. After certain energy the swelling disappears and the interaction is dominated by the ablated hole. This behaviour is independent of laser polarization. The threshold energy at which the hole size coincides with size of swelling is 1.5 times that of the threshold for surface swelling. 2D molecular dynamics simulations show surface swelling at low pulse energies along with void formation below the surface within the interaction region. Simulations show that at higher energies, the voids coalesce and grow, and the interaction is dominated by material ejection.
Dysfunction of Simian Immunodeficiency Virus/Simian Human Immunodeficiency Virus-Induced IL-2 Expression by Central Memory CD4+ T Lymphocytes (2005)

Production of IL-2 and IFN-gamma by CD4+ T lymphocytes is important for the maintenance of a functional immune system in infected individuals. In the present study, we assessed the cytokine production profiles of functionally distinct subsets of CD4+ T lymphocytes in rhesus monkeys infected with pathogenic or attenuated SIV/simian human immunodeficiency virus (SHIV) isolates, and these responses were compared with those in vaccinated monkeys that were protected from immunodeficiency following pathogenic SHIV challenge. We observed that preserved central memory CD4+ T lymphocyte production of SIV/SHIV-induced IL-2 was associated with disease protection following primate lentivirus infection. Persisting clinical protection in vaccinated and challenged monkeys is thus correlated with a preserved capacity of the peripheral blood central memory CD4+ T cells to express this important immunomodulatory cytokine.
Optical projection lithography at half the Rayleigh resolution limit by two photon exposure (2002)

In recent years, with the advent of femtosecond pulse technology, two-photon absorption has commenced to be used for exposing photo-resists. It is natural to ask then, what is the spatial resolution of two-photon lithography? There has already been some discussion of resolution limits in two-photon, scanning confocal fluorescence microscopy. We will find that ordinary two-photon exposure of photo-resist merely enhances the photographic contrast, or gamma. While this improves the spatial resolution somewhat, it does so at the expense of a requirement for tighter control over the incident light intensity. Instead, we introduce a new type of exposure system employing a multiplicity of 2-photon excitation frequencies which interfere with one another to produce a super-resolution stationary image, exhibiting a true doubling of the spatial resolution.
[Effective alendronate therapy against a bone metastasis occurring during docetaxel therapy for breast cancer--a case report]. (1999)

A 65-year-old woman underwent radical operation for breast cancer in December, 1992. Between September, 1994 and January, 1997, she developed local recurrences four times as well as a supraclavicular lymph node recurrence. Each recurrence was treated with surgery and various types of chemoendocrine therapy, including anthracycline-containing chemotherapy. In April, 1997, she had developed a liver metastasis, which showed a partial response to docetaxel therapy. However, she developed a bone metastasis in January, 1998 (9 months after the initiation of docetaxel therapy). In addition to the docetaxel therapy, she was treated with a potent bisphosphonate, alendronate, 10 mg of which was infused every two weeks. Eight alendronate infusions resulted in a marked improvement in the bone metastasis, and the liver metastasis has been in regression for 13 months in response to the docetaxel therapy. In conclusion, alendronate is a promising agent against bone metastases which occur during docetaxel therapy for breast cancer.
Thromboembolization Associated with Sudden Increases in Flow in a Coronary Stent Ex Vivo Shunt Model (2000)

To observe the dynamics of thromboembolism (TE) in an animal model, a carotid-carotid arterial ex vivo shunt was developed. A coronary stent deployed in a 3.5 mm polyvinylchloride (PVC) tubing segment was used as a model device in the shunt. A light-scattering microemboli detector monitored the embolic content of the blood flowing through the shunt at 50-150 ml/min as determined by a clamp-on ultrasound flow probe. The stent was found to actively develop thrombi and release emboli for 1-3 hours when the activated clotting time (ACT) was maintained between 125 and 150 seconds. The shunt flow rate fluctuated considerably (from 50 to 150 ml/min) depending on the animal's activity. When the time profile of this fluctuating flow rate was super imposed on the time profile of embolization, it was noted that sudden increases in flow rate were associated with incidents of embolization. Statistically, sudden flow rate increases of 100% or more were accompanied by embolic events 95% of the time (p < 0.01). Based on the results of this study, it was postulated that the increased embolization may be due to the fluid forces associated with accelerating flow. To explore this postulate, in vitro studies were conducted to compare the effects of pulsatile flow with steady flow on stent induced TE. Results of this study suggested a significant increase (100%) in both stent thrombosis and embolism during pulsatile flow compared with steady flow.
Novel Orthogonal Synthesis of a Tagged Combinatorial Triazine Library via Grignard Reaction (2009)

To expand the diversity of 1,3,5-triazine libraries to aryl and alkyl functionalities through the C–C bond, we employed a novel orthogonal synthesis via Grignard monoalkylation or monoarylation of cyanuric chloride in solution to prepare aryl- or alkyl-substituted triazine building blocks. These aryl- or alkyl-substituted triazine building blocks were captured by a resin-bound amine, followed by amination and acidic cleavage with high purity. Herein, we demonstrate a novel orthogonal synthesis of a tagged aryl- and alkyl-triazine library on solid support, utilizing building blocks prepared via Grignard reaction in solution. Through incorporation of a triethylene glycol linker at one of the alternate sites on the triazine scaffold we explored an intrinsic tagged library approach.
Structure and Expression of Rat and Mouse mRNAs for Zn- α2 -Glycoprotein1 (1994)

Rat and mouse cDNAs for Zn-alpha 2-glycoprotein (Zn alpha 2gp) were isolated from liver libraries (lambda gt11) and compared with the human one. The lengths of cDNA inserts analyzed were 1,233 and 1,273 nucleotides for rat and mouse, respectively. The deduced amino acid sequences suggested that rat and mouse Zn alpha 2gp proteins consist of 279 and 290 amino acid residues in the mature form, respectively. They have 59.4% (rat) and 58.6% (mouse) identities in amino acid sequence with the human counterpart, and between rat and mouse the identity is 88.5%. Among the three domains, domain B is best conserved; the identities are 74.7, 73.6, and 95.6% between human and rat, human and mouse, and rat and mouse, respectively. Four cysteine and eight tryptophan residues are all conserved, and two of the three asparagine residues that carry a glycan in the human protein are conserved. Analysis of rat tissues by Northern blot suggested that its mRNA is expressed in liver, and, to a much lesser extent in submandibular gland, lung, kidney, and stomach. A more detailed study by in situ hybridization demonstrated that some epithelial cells of renal tubules and the isthmus and the neck zone cells of gastric fundic glands express Zn alpha 2gp mRNA.
Analysis of Variations in Farm Real Estate Prices Over Homogeneous Market Areas in the Southeast (1983)

This article presents an analysis of factors influencing farm real eatate prices in the southeastern United States. The first step in the analysis is the use of a multivariate criterion to segment the regional market into homogeneous land resource components.
Positive-end expiratory pressure reduces incidence of ventilator-associated pneumonia in nonhypoxemic patients* (2008)

These findings indicate that application of prophylactic PEEP in nonhypoxemic ventilated patients reduces the number of hypoxemia episodes and the incidence of ventilator-associated pneumonia.
Endothelial Dysfunction and Damage in Congestive Heart Failure (2004)

Ample evidence of endothelial cell damage/dysfunction in CHF cannot be fully explained by the variance in plasma BNP per se. Therefore, the routes by which these indexes influence the pathophysiology of CHF as well as predict adverse outcomes may be independent.
Chemistry and Biology of the Initial Steps in Vision: The Friedenwald Lecture (2014)

Visual transduction is the process in the eye whereby absorption of light in the retina is translated into electrical signals that ultimately reach the brain. The first challenge presented by visual transduction is to understand its molecular basis. We know that maintenance of vision is a continuous process requiring the activation and subsequent restoration of a vitamin A-derived chromophore through a series of chemical reactions catalyzed by enzymes in the retina and retinal pigment epithelium (RPE). Diverse biochemical approaches that identified key proteins and reactions were essential to achieve a mechanistic understanding of these visual processes. The three-dimensional arrangements of these enzymes' polypeptide chains provide invaluable insights into their mechanisms of action. A wealth of information has already been obtained by solving high-resolution crystal structures of both rhodopsin and the retinoid isomerase from pigment RPE (RPE65). Rhodopsin, which is activated by photoisomerization of its 11-cis-retinylidene chromophore, is a prototypical member of a large family of membrane-bound proteins called G protein-coupled receptors (GPCRs). RPE65 is a retinoid isomerase critical for regeneration of the chromophore. Electron microscopy (EM) and atomic force microscopy have provided insights into how certain proteins are assembled to form much larger structures such as rod photoreceptor cell outer segment membranes. A second challenge of visual transduction is to use this knowledge to devise therapeutic approaches that can prevent or reverse conditions leading to blindness. Imaging modalities like optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) applied to appropriate animal models as well as human retinal imaging have been employed to characterize blinding diseases, monitor their progression, and evaluate the success of therapeutic agents. Lately two-photon (2-PO) imaging, together with biochemical assays, are revealing functional aspects of vision at a new molecular level. These multidisciplinary approaches combined with suitable animal models and inbred mutant species can be especially helpful in translating provocative cell and tissue culture findings into therapeutic options for further development in animals and eventually in humans. A host of different approaches and techniques is required for substantial progress in understanding fundamental properties of the visual system.
High‐Efficiency Dielectric Huygens’ Surfaces (2015)

Optical metasurfaces have developed as a breakthrough concept for advanced wave‐front engineering enabled by subwavelength resonant nanostructures. However, reflection and/or absorption losses as well as low polarization‐conversion efficiencies pose a fundamental obstacle for achieving high transmission efficiencies that are required for practical applications. Here, for the first time to our knowledge, highly efficient all‐dielectric metasurfaces are demonstrated for NIR frequencies using arrays of silicon nanodisks as metaatoms. The main features of Huygens' sources are employed, namely, spectrally overlapping crossed electric and magnetic dipole resonances of equal strength, to demonstrate Huygens' surfaces with full transmission‐phase coverage of 360° and near‐unity transmission. Full‐phase coverage combined with high efficiency in transmission are experimentally confirmed. Based on these key properties, all‐dielectric Huygens' metasurfaces can become a new paradigm for flat optical devices, including beam‐steering, beam‐shaping, and focusing, as well as holography and dispersion control.
Studies of Cardiotonic Agents. 8. Synthesis and Biological Activities of Optically Active 6-(4-(Benzylamino)-7-quinazolinyl)-4,5-dihydro-5-methyl- 3(2<i>H</i>)-pyridazinone (KF15232) (1996)

We previously reported that (+/-)-6-(4-(benzylamino)-7-quinazolinyl)-4,5- dihydro-5-methyl-3(2H)-pyridazinone (+/-)-1, KF15232) showed potent cardiotonic activity with a strong myofibrillar Ca(2+)-sensitizing effect. As an extension of our work, we attempted to synthesize optically active 1. (+/-)-4-(4-(Benzylamino)-7-quinazolinyl)-3-methyl-4-oxobutyric acid (-)-menthyl ester (6) was separated into both diastereoisomers, and each was converted to optically pure 1 (> 99% ee) in an enantioselective manner. In order to determine the absolute configuration of the isomers, an alternative synthesis of optically active 1 was employed. The precursor of (-)-1 ((+)-9) was obtained by enantioselective synthesis from (R)-D-alanine. Consequently, we concluded that the absolute configuration of (-)-1 at the 5-position of the pyridazinone ring was R. The cardiotonic effects and inhibitory activities to PDE III and V of racemic 1 and (-)-1 were more potent than those of (+)-1. These compounds also demonstrated greater vasorelaxant effects in guinea pig aorta. In contrast, (+)-1 showed only weak cardiotonic and vasodilating effects, although the compound displayed potent Ca(2+)-sensitizing activity. Racemic and (-)-1 attracted our interest for the treatment of congestive heart failure.
H. Hugh Corbin at the University of Adelaide School of Forestry, 1912–1925 (2013)

Hugh Corbin developed the first degree-level university-affiliated forestry course in Australia as Lecturer in Forestry at the University of Adelaide. From its beginnings in 1912 to 1925, the University of Adelaide graduated twenty forestry professionals. Simultaneously Corbin was busy with promotional, consultancy and research work. The future of the school became entwined in the protracted debate over a central forestry school for all Australia. For a time Corbin believed Adelaide would fill this role, but this proved a forlorn hope—in 1925 the Adelaide course closed after it was announced that the Commonwealth Government would fund a new Australian Forestry School, whereupon he departed to become Professor of Forestry at Auckland University College in New Zealand.
Exploiting Tractable Substructures in Intractable Networks (1995)

We develop a refined mean field approximation for inference and learning in probabilistic neural networks. Our mean field theory, unlike most, does not assume that the units behave as independent degrees of freedom; instead, it exploits in a principled way the existence of large substructures that are computationally tractable. To illustrate the advantages of this framework, we show how to incorporate weak higher order interactions into a first-order hidden Markov model, treating the corrections (but not the first order structure) within mean field theory. 1 INTRODUCTION Learning the parameters in a probabilistic neural network may be viewed as a problem in statistical estimation. In networks with sparse connectivity (e.g. trees and chains), there exist efficient algorithms for the exact probabilistic calculations that support inference and learning. In general, however, these calculations are intractable, and approximations are required. Mean field theory provides a framework for app...
Another Journal on Nanomaterials? (2010)

It is my great pleasure to welcome you to Nanomaterials, a new open access journal, which is dedicated to the fabrication, characterization, functionalization, modeling and application of nanomaterials. In answer to the title question, I would like to (mis)quote one of my favourite pieces of literature: I "[We] hold these truths to be self-evident, that all men ... are endowed ... with certain unalienable rights, that among these are ..." free access to information and education. The prime goal of Nanomaterials is to publish first-class, original research articles under an open access policy with minimal fees for the authors. The quality of the published articles will be assured by a fast yet rigorous peer-review process. [...].
The occurrence of duplicate lysyl-tRNA synthetase gene homologs in Escherichia coli and other procaryotes (1995)

The lysyl-tRNA synthetase (LysRS) system of Escherichia coli K-12 consists of two genes, lysS, which is constitutive, and lysU, which is inducible. It is of importance to know how extensively the two-gene LysRS system is distributed in procaryotes, in particular, among members of the family Enterobacteriaceae. To this end, the enterics E. coli K-12 and B; E. coli reference collection (ECOR) isolates EC2, EC49, EC65, and EC68; Shigella flexneri; Salmonella typhimurium; Klebsiella pneumoniae; Enterobacter aerogenes; Serratia marcescens; and Proteus vulgaris and the nonenterics Pseudomonas aeruginosa and Bacillus megaterium were grown in AC broth to a pH of 5.5 or less or cultured in SABO medium at pH 5.0. These growth conditions are known to induce LysRS activity (LysU synthesis) in E. coli K-12. Significant induction of LysRS activity (twofold or better) was observed in the E. coli strains, the ECOR isolates, S. flexneri, K. pneumoniae, and E. aerogenes. To demonstrate an association between LysRS induction and two distinct LysRS genes, Southern blotting was performed with a probe representing an 871-bp fragment amplified from an internal portion of the coding region of the lysU gene. In initial experiments, chromosomal DNA from E. coli K-12 strain MC4100 (lysS+ lysU+) was double digested with either BamHI and HindIII or BamHI and SalI, producing hybridizable fragments of 12.4 and 4.2 kb and 6.6 and 5.2 kb, respectively. Subjecting the chromosomal DNA of E. coli K-12 strain GNB10181 (lysS+ delta lysU) to the same regimen established that the larger fragment from each digestion contained the lysU gene. The results of Southern blot analysis of the other bacterial strains revealed that two hybridizable fragments were obtained from all of the E. coli and ECOR collection strains examined and S. flexneri, K. pneumoniae, and E. aerogenes. Only one lysU homolog was found with S. typhimurium and S. marcescens, and none was obtained with P. vulgaris. A single hybridizable band was found with both P. aeruginose and B, megaterium. These results show that the dual-gene LysRS system is not confined to E. coli K-12 and indicate that it may have first appeared in the genus Enterobacter.
Remote manipulator and its teleoperated guide vehicle for hazardous waste sampling operations (2002)

A remote manipulator and its teleoperated guide vehicle were developed for laser-aided surface sampling operations at hazardous waste sites. This equipment was designed to reduce or eliminate human interaction with the hazardous contaminants. The 3 degree-of-freedom (DOF) remote manipulator with a sampling probe mounted on the end of the robotic arm is operated either by a master/slave controller or a computer keyboard command. The teleoperated guide vehicle moves by remote control the manipulator (mounted on a trailer) into the desired sampling locations in the contaminated field. This paper deals with the mechanical design considerations, control system, and capabilities of both the manipulator and the teleoperated guide vehicle. The results of field tests are also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Apology and Organizations: Exploring an Example from Medical Practice (2000)

In this Article, I focus on injuries committed by members of organizations, such as corporations, and examine distinct issues raised by apology in the organizational setting. In particular, I consider: (i) the process of learning to prevent future errors; (ii) the divergent interests stemming from principal-agent tensions in employment, risk preferences and sources of insurance; (iii) the non-pecuniary benefits to corporate morale, productivity and reputation; (iv) the standing and scope of apologies; and (v) the articulation of policies toward injuries to others.
The Impact of Corporate Social Responsibility on Human Resource Management: GDF SUEZ’s Case (2013)

This paper aims to analyse GDF SUEZ’s sustainable development report, focusing on its involvement in socially responsible Human Resource Management practices. We seek to know how Corporate Social Responsibility (CSR) affects HR functions, roles, and activities. According to Fortune magazine, GDF SUEZ ranks first among companies in the world in terms of social responsibility and is among the top 10 global companies across all sectors. Our research focuses on the following practices: recruitment and employment access, training and career development, and well-being in the workplace. These HRM practices seem important to analyse given the context in which companies will have to evolve: ageing of the population, risks of labour shortage, or the war for talent. Our results imply that CSR has a positive influence on employees’ advocacy role (Ulrich & Brockbank, 2005) because the Group integrates concerns regarding equal treatment, health and safety, and diversity. We also believe that GDF SUEZ Group desires to develop its brand further by presenting itself as a responsible employer to harvest the benefits that flow from that label.