gebhart/patrepeval huggingface dataset:
Expression of S‐laminin and laminin in the developing rat central nervous system (1992)

The extracellular matrix component, s-laminin, is a homologue of the B1 subunit of laminin. S-laminin is concentrated in the synaptic cleft at the neuromuscular junction and contains a site that is adhesive for motor neurons, suggesting that it may influence neuromuscular development. To ascertain whether s-laminin may also play roles in the genesis of the central nervous system, we have examined its expression in the brain and spinal cord of embryonic and postnatal rats. S-laminin was not detectable in synapse-rich areas of adults. However, s-laminin was present in discrete subsets of three laminin-containing structures: (1) In the developing cerebral cortex, laminin and s-laminin were expressed in the subplate, a transient layer through which neuroblasts migrate and cortical afferents grow. Both laminin and s-laminin disappeared as embryogenesis proceeded; however, laminin was more widely distributed and present longer than s-laminin. (2) In the developing spinal cord, laminin was present throughout the pia. In contrast, s-laminin was concentrated in the pia that overlies the floor plate, a region in which extracellular cues have been postulated to guide growing axons. (3) In central capillaries, s-laminin appeared perinatally, an interval during which the blood-brain barrier matures. In contrast, laminin was present in capillary walls of both embryos and adults. To extend our immunohistochemical results, we used biochemical methods to characterize s-laminin in brain. We found that authentic s-laminin mRNA is present in the embryonic brain, but that brain-derived s-laminin differs (perhaps by a posttranslational modification) from that derived from nonneural tissues. We also used tissue culture methods to show that glia are capable of synthesizing "brain-like" s-laminin, and of assembling it into an extracellular matrix. Thus, glia may be one cellular source of s-laminin in brain. Together, these results demonstrate that s-laminin is present in the developing central nervous system, and raise the possibility that this molecule may influence developmental processes.
DNA-DNA homology among lactose- and sucrose-fermenting transconjugants from Lactococcus lactis strains exhibiting reduced bacteriophage sensitivity (1989)

DNA-DNA homology between a reduced bacteriophage sensitivity (Rbs+) probe and DNA from both Rbs+ and Rbs- Lactococcus lactis strains was examined. Homology was detected between the probe and five plasmids (pCI750, pCC34, pEB56, pNP2, and pJS88) isolated from lactose-positive Rbs+ transconjugants and between the probe and genomic DNA of a sucrose-positive Rbs+ transconjugant. Additionally, hybridizations conducted between the probe and plasmids reported to encode abortive bacteriophage infection indicated homology with pTR2030 but not with pBF61 and pGBK17. The results suggest that a common genetic determinant(s) may be present in a variety of lactococcal plasmids coding for Rbs+.
Practical Lessons from Developing a Large-Scale Recommender System at Zalando (2017)

Developing a real-world recommender system, i.e. for use in large-scale online retail, poses a number of different challenges. Interestingly, only a small part of these challenges are of algorithmic nature, such as how to select the most accurate model for a given use case. Instead, most technical problems usually arise from operational constraints, such as: adaptation to novel use cases; cost and complexity of system maintenance; capability of reusing pre-existing signal and integrating heterogeneous data sources.
Confinement of Supported Metal Catalysts at High Loading in the Mesopore Network of Hierarchical Zeolites, with Access via the Microporous Windows (2017)

High loading on a porous support is important for preparing high-performance metal catalysts, but the increased loading often results in a loss of dispersion and limited mass transfer. We approached this problem by supporting a large amount of metal or metal oxide on a hierarchically porous zeolite. The supported catalyst formed an embedded network of nanowires along the zeolite mesopores. Although tightly filled in the mesopores, the catalyst was readily accessible through microporous windows at the encasing mesopore walls. Cobalt, nickel, and TiO2, supported in this manner, exhibited high catalytic performance in Fischer–Tropsch synthesis, benzene hydrogenation, and furfural-to-γ-valerolactone conversion, respectively.
Spinocerebellar Ataxia Type 6 Mutation Alters P-type Calcium Channel Function (2000)

Abnormal CAG repeat expansion in the alpha1A voltage-dependent calcium channel gene is associated with spinocerebellar ataxia type 6, an autosomal dominant cerebellar ataxia with a predominant loss of the Purkinje cell. A reverse transcriptase-polymerase chain reaction analysis of mRNA from mouse Purkinje cells revealed a predominant expression of the alpha1A channel lacking an asparagine-proline (NP) stretch in the domain IV (alpha1A(-NP)). Human alpha1A channels carrying various polyglutamine length with or without NP were expressed in HEK293 cells, and channel properties were compared using a whole-cell voltage clamp technique. alpha1A(-NP), corresponding to P-type channel, with 24 and 28 polyglutamines found in patients showed the voltage dependence of inactivation shifting negatively by 6 and 11 mV, respectively, from the 13 polyglutamine control. Contrarily, the alpha1A channel with NP (alpha1A(+NP)), corresponding to Q-type channel, with 28 polyglutamines exhibited a positive shift of 5 mV. These results suggest that altered function of alpha1A(-NP) may contribute to degeneration of Purkinje cells, which express predominantly alpha1A(-NP), due to the reduced Ca(2+) influx resulting from the negative shift of voltage-dependent inactivation. On the other hand, other types of neurons, expressing both alpha1A(-NP) and alpha1A(+NP), may survive because the positive shift of voltage-dependent inactivation of alpha1A(+NP) compensates Ca(2+) influx.
The biosynthesis of unsaturated fatty acids by bacilli. I. Temperature induction of the desaturation reaction. (1969)

The biosynthesis of unsaturated fatty acids in bacilli has been investigated by studying the way that various species and strains carry out the desaturation of palmitic-1-14C acid. By this method, two distinct desaturation systems have been elucidated. One system, found in six different strains, results in the conversion of palmitate to 5-hexadecenoate, with no other double bond isomers appearing. A second system, found in five strains, results in a spectrum of double bond isomers centering around position 9 but including Δ8 and Δ10 isomers, sometimes as the major constituents. The two desaturating systems are further differentiated by the manner in which they respond to temperature changes of the medium. Thus, cultures desaturating palmitic acid in positions 8, 9, or 10 show no significant change in desaturation rate when the temperature of incubation with palmitate is varied between 20° and 30° (or in the case of Bacillus stearothermophilus 12977, between 20° and 60°). On the other hand, the rate of desaturation of palmitate to 5-hexadecenoate is under strict temperature control. Bacillus megaterium 14581 and other Δ5-desaturating bacilli desaturate palmitate readily at 20° but not at 30°. The rate of desaturation of palmitate is determined by the temperature at which the cultures are incubated with this substrate and not by the temperature of growth. Thus, B. megaterium grown at either 20° or 30° desaturates palmitate at 20° but does not do so at 30°. Further investigation of the temperature effect revealed that the Δ5-desaturating enzyme of B. megaterium is not present at 30° but can be induced by previously incubating a 30° grown culture at 20° for 1 or 2 hours. Chloramphenicol, if added at the beginning of the preliminary incubation period, completely prevents induction of the enzyme but has only an inhibitory effect, increasing with time, if added after preliminary incubation. This inhibitory effect at 20° is presumably due to slow inactivation of desaturating enzyme under circumstances in which replenishment by further protein synthesis is blocked. The induced enzyme is much more rapidly destroyed at 30°. Cultures grown in medium lacking iron have no desaturating activity but activity can be restored by the addition of iron (as ferric ammonium citrate) to the incubation medium. However, iron is not necessary for the temperature induction of the desaturating enzyme but rather appears to be acting as a cofactor in the desaturating system.
Near-surface P-velocity modelling by integrated seismic, EM, and gravity data: examples from the Middle East (2008)

D. Colombo1*, M. Cogan2, S. Hallinan3, M. Mantovani3, M. Virgilio3 and W. Soyer provide some onshore Middle East illustrations of the benefits of integrating seismic, electromagnetic (EM) and gravity data to improve shallow velocity modelling.
Fourier treatment of near-field scalar diffraction theory (1979)

A general treatment of scaler diffraction theory is presented and some interesting concepts are discussed which yield new insight into the phenomena of diffraction throughout the whole space in which it occurs. The direct application of Fourier transform theory to the diffraction process results in two equivalent descriptions of the diffracted wave field: one describes the wave field as a superposition of plane-wave components and corresponds to the transfer function approach in linear systems theory, and the other describes the wave field as a superposition of hemispherical-wave components (or Huygen wavelets) and corresponds to the impulse response approach in linear systems theory. The convolution of the initial disturbance with the impulse response results in the well-known Rayleigh-Sommerfeld formula for near-field diffraction. This formula is then rewritten in the form of the Fourier transform integral of a generalized pupil function which includes phase variations in the diffracting aperture. Any departures of the actual diffracted wave field from that predicted by the Fourier transform of the aperture function are shown to have the same functional form as the conventional wave-front aberrations of imaging systems. These aberrations are precisely the effects ignored when making the usual Fresnel and Fraunhofer approximations.
Computer-aided modeling for interference analysis in urban areas (2003)

A new computer-aided approach for interference analysis in urban areas is presented. The proposed method integrates a three-dimensional (3D) geographical database, propagation path analysis by computational geometry, and diffraction and reflection modeling. Applying geometrical algorithms to 3D geographical data comprising buildings and ground elevations, interference propagation paths, including diffraction and reflection, are searched. Propagation models are investigated with field measurements to represent diffraction at building edges and reflection by building walls, including nonspecular scattering. An overall procedure integrating these techniques for interference estimation is presented together with practical applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Enhancement of Sexual Motivation in Sexually Naive Male Mice by Eurycoma longifolia (1997)

Eurycoma longifolia was preliminary investigated for aphrodisiac property on sexually naive male mice using both the modified runway-choice and open field methods. The animals were conditioned to seek, either an estrous female, a measure of right choice for sexual motivation or a male mouse, a measure of wrong choice, within two minutes. However, male mice which failed to response within the stipulated period were considered as having no choice. Oral administration of 0.5 g/kg daily of different fractions of E. longifolia viz., chloroform, methanol, water and butanol resulted in an enhancement of the sexual motivation of the animals after three days post-treatment and the effect was more prominent after eight days post-treatment.
Epidermal Growth Factor–Like Domain 7 Is a Novel Inhibitor of Neutrophil Adhesion to Coronary Artery Endothelial Cells Injured by Calcineurin Inhibition (2011)

Our study reveals that Egfl7 is a potent inhibitor of neutrophil adhesion to human coronary endothelial cells subsequent to calcineurin-inhibition-induced injury. Mechanistically, Egfl7 blocked nuclear factor-κB pathway activation and intercellular adhesion molecule-1 expression, which suggests that it may have significant antiinflammatory properties. Because Jagged1 blocked the effect of Egfl7, Notch receptor antagonism may contribute to the mechanism of action of Egfl7.
Handling system for nuclear fuel pellet inspection (1978)

HEDL is developing automated fabrication equipment for fast reactor fuel. A major inspection operation in the process is the gaging of fuel pellets. A key element in the system has been the development of a handling system that reliably moves pellets at the rate of three per second without product damage or excessive equipment wear.
Deposition of functionalized calcium phosphate nanoparticles on functionalized polymer surfaces (2006)

Abstract Calcium phosphate nanoparticles were functionalized using two polymeric additives: polyallylamine hydrochloride, PAH, giving them a positive charge, and polyacrylic acid, PAA, giving them a negative charge. These particles were deposited on surface‐functionalized polymers (polyethylene terephthalate track‐etch membranes; PET) by dip‐coating. If the charge of the nanoparticles and the charge of the polymer membrane had an opposite sign, efficient adsorption was observed, whereas on unfunctionalized polymer surfaces, no adsorption occurred.
High-speed uncooled infrared detector (1987)

Stock AL-107 and AL-115 light-emitting diodes are tested as uncooled detectors of CO/sub 2/-laser radiation. The light-emitting diodes were found to be sensitive to infrared radiation. The sensitivity and speed can be varied from 10/sup -3/ to 10/sup -5/ V/W and from 10/sup -3/ to 10/sup -8/ sec, respectively, depending on the operating conditions.
Thermoplastic polymer patterning without residual layer by advanced nanoimprinting schemes (2009)

Nanoimprinting is a fast-growing technique for nanoscale patterning. One of the remaining issues in nanoimprinting is the removal of the residual layer after nanoimprinting. Traditionally the residual layer is removed by an oxygen reactive-ion etching (RIE) step. The need for a vacuum environment and dedicated equipment in this step lowers the throughput and increases the cost of the nanoimprinting process. It also prevents the possibility of patterning isolated functional polymers because oxygen RIE destroys the functional materials. In this work, novel nanoimprinting schemes are developed to nondestructively remove the residual layer in thermal nanoimprinting by solvent developing and dewetting. Combined with a transfer-bonding technique, three-dimensional polymer scaffolds are achieved. The techniques developed here eliminate the RIE step in thermal nanoimprinting and are compatible with roller nanoimprinting for large-scale patterning of polymer micro- or nanostructures. The technique also opens up new applications for nanoimprinting in patterning isolated conjugated polymers for organic electronic devices and circuits.
Two petroleum additives deals stall on the consolidation trail (1992)

The consolidation of the lubricant and fuel additives market is turning out to be anything but a slick transition. Two deals have fallen through since the beginning of April. Ethyl Corp. (Richmond, VA) has discontinued negotiations for the acquisition of BP Chemicals` (London) Adibis petroleum additives business and Lubrizol`s (Wickliffe, OH) proposed purchase of Amoco Chemical`s petroleum additives business is stalled, and may be completely derailed by antitrust concerns. Meanwhile, a third petroleum additives business, the European joint venture between Amoco and Finzis being liquidated.
SMPTE Type C Helical-Scan Recording Format (1978)

About two years ago there was little prospect that a 1-in helical-scan videotape recorded on one manufacturer's machine could ever be played back on another manufacturer's VTR. In a single year, however, this situation has changed and the SMPTE Standards Committee has approved the basic format documents for high-quality 1-in helical-scan VTRs capable of interchanging tapes. Topics covered in detail in the paper include: the process of developing a standard, with a list of the relevant ANSI and SMPTE documents; helical video format parameters, with definitions and criteria for their selection; location of tape tracks; video and sync records, with sources and magnitudes of various time-base errors; limitation of vertical-interval dropout; the requirement for six heads; the contraints of video track straightness and longitudinal track dimensions; audio and control-track recording; and video signal processing. It is expected that the new SMPTE Type C format will provide a practical solution to the users' requirements for tape interchange.
Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis (2015)

We previously reported that i) a Western diet increased levels of unsaturated lysophosphatidic acid (LPA) in small intestine and plasma of LDL receptor null (LDLR(-/-)) mice, and ii) supplementing standard mouse chow with unsaturated (but not saturated) LPA produced dyslipidemia and inflammation. Here we report that supplementing chow with unsaturated (but not saturated) LPA resulted in aortic atherosclerosis, which was ameliorated by adding transgenic 6F tomatoes. Supplementing chow with lysophosphatidylcholine (LysoPC) 18:1 (but not LysoPC 18:0) resulted in dyslipidemia similar to that seen on adding LPA 18:1 to chow. PF8380 (a specific inhibitor of autotaxin) significantly ameliorated the LysoPC 18:1-induced dyslipidemia. Supplementing chow with LysoPC 18:1 dramatically increased the levels of unsaturated LPA species in small intestine, liver, and plasma, and the increase was significantly ameliorated by PF8380 indicating that the conversion of LysoPC 18:1 to LPA 18:1 was autotaxin dependent. Adding LysoPC 18:0 to chow increased levels of LPA 18:0 in small intestine, liver, and plasma but was not altered by PF8380 indicating that conversion of LysoPC 18:0 to LPA 18:0 was autotaxin independent. We conclude that i) intestinally derived unsaturated (but not saturated) LPA can cause atherosclerosis in LDLR(-/-) mice, and ii) autotaxin mediates the conversion of unsaturated (but not saturated) LysoPC to LPA.
The Arabidopsis<i>Somatic Embryogenesis Receptor Kinase 1</i>Gene Is Expressed in Developing Ovules and Embryos and Enhances Embryogenic Competence in Culture (2001)

We report here the isolation of the Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 1 (AtSERK1) gene and we demonstrate its role during establishment of somatic embryogenesis in culture. The AtSERK1 gene is highly expressed during embryogenic cell formation in culture and during early embryogenesis. The AtSERK1 gene is first expressed in planta during megasporogenesis in the nucellus [corrected] of developing ovules, in the functional megaspore, and in all cells of the embryo sac up to fertilization. After fertilization, AtSERK1 expression is seen in all cells of the developing embryo until the heart stage. After this stage, AtSERK1 expression is no longer detectable in the embryo or in any part of the developing seed. Low expression is detected in adult vascular tissue. Ectopic expression of the full-length AtSERK1 cDNA under the control of the cauliflower mosaic virus 35S promoter did not result in any altered plant phenotype. However, seedlings that overexpressed the AtSERK1 mRNA exhibited a 3- to 4-fold increase in efficiency for initiation of somatic embryogenesis. Thus, an increased AtSERK1 level is sufficient to confer embryogenic competence in culture.
“Communication on Copyright.” Maud Karpeles. (<i>Western Folklore</i>, Vol. XXII, No. 3, pp. 187–189, Berkeley, July, 1963.) (1964)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Joint debridement--a complement to high tibial osteotomy in the treatment of degenerative arthritis of the knee (1977)

In order to understand the promoting effect of V compd. on Rh catalysts in synthesis gas conversion, changes in reaction rates of elementary steps and the surface concn. of intermediates have been monitored. V promotion enhances the rate of CO dissocn. which is the most important effect. Reactive surface carbon is stabilized by V which results in a slightly decreased reactivity in methane formation. Transient expts. using isotopes and GCMS detection show that CO insertion is not promoted by V. The hydrogenation of ethanal to ethanol is enhanced by V while the desorption rate of ethanal is decreased
Molecular monitoring in chronic myeloid leukemia (2008)

The majority of patients with chronic-phase (CP) chronic myeloid leukemia (CML) who are treated with Bcr-Abl tyrosine kinase inhibitors such as imatinib and dasatinib achieve cytogenetic disease remission (ie, Philadelphia chromosome-positive cells undetectable by cytogenetic evaluation). However, more sensitive methods are required for monitoring residual disease (ie, molecular monitoring of BCR-ABL transcript levels). It is generally accepted that molecular responses have prognostic significance. Patients with CP CML who achieve early molecular responses are more likely to achieve durable cytogenetic responses and are less likely to experience disease progression. Rising BCR-ABL transcript levels also indicate loss of response, often as a consequence of developing BCR-ABL mutations. However, some studies have suggested that patients who achieve complete cytogenetic disease remission may not derive an additional prognostic benefit from achieving a major molecular response. Practical issues also exist for molecular monitoring with respect to restricted access and variability in methodologies and data reporting. Although molecular monitoring has a clear role in assessing residual disease and determining the risk of disease progression in patients with CML, the importance of cytogenetic monitoring should not be ignored.
Distribution of soft wheat kernel lipids into flour milling fractions (1981)

Abstract Samples of whole and manually degermed Atou wheat were milled on a micro‐mill to give straight‐run flour, coarse offal, fine offal, finished bran and bran finisher flour. The non‐starch lipids in these products were compared with non‐starch lipids in the aleurone‐free starchy endosperm, and with lipids in the germ and aleurone of the original wheat. About half of the triglyceride in flour was derived from the germ; no glycolipids or phospholipids were derived from germ, and no lipids of any kind were derived from the aleurone. Non‐starch lipids in the aleurone‐free endosperm of a mixed English soft wheat grist were then compared with the non‐starch lipids in 11 flour streams from a commercial mill. All flours had much more triglyceride than the endosperm. In flours from the reduction system there were significant correlations between flour colour grade, sterylester, triglyceride, diglyceride, free fatty acid and diacylphospholipids, but none between ash or protein and colour or any class of lipid. Analysis of the principal components of variation in a simplified matrix describing all 11 flours placed triglyceride, diglyceride, free fatty acid, and diacylphospholipids close together in one group, and all glycolipids and N ‐acylphospholipids in a separate unrelated group. Sterylester and colour were loosely associated with the first group but could also be regarded as part of a third loose group with ash and protein. The results are interpreted in terms of lipid distribution within the wheat kernel, and their significance in milling and baking practice.