gebhart/patrepeval huggingface dataset:
Video Compression for Ocean Simulation Image Databases (2017)

Climate research requires monitoring a large range of spatial and temporal scales to understand the climate system and potential future impacts. Climate simulations are now run with very high resolution (1-10 km gridcells) ocean, sea ice, and atmosphere components, and can easily produce petabytes of output. This overloads storage systems and hinders visualization and analysis. Image databases can decrease storage sizes from petabytes of simulation output down to several hundred gigabytes of images. In this paper, we introduce video compression as a method to further decrease database sizes by 2-4 orders of magnitude. We compare compression and access speeds, compressed sizes, and compression quality over a range of settings. Quality is assessed through image quality metrics and expert feedback. Overall, we were able to show that video compression techniques provide an efficient means of storing image databases at a shareable size, while preserving image quality. This enables the wise use of available disk space, so scientists can more easily study the physical features of interest.
Use of Saliva-Based Nano-Biochip Tests for Acute Myocardial Infarction at the Point of Care: A Feasibility Study (2009)

Complementary to ECG, saliva-based tests within lab-on-a-chip systems may provide a convenient and rapid screening method for cardiac events in prehospital stages for AMI patients.
Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo (1995)

Previously we have found that sera from immunocompetent mice infected either naturally by ticks or experimentally with low numbers of Borrelia burgdorferi ZS7 bacteria lack OspA- and OspB-specific antibodies but confer optimal protection on severe combined immunodeficiency mice against challenge with spirochetes (U.E. Schaible, L. Gern, R. Wallich, M. D. Kramer, M. Prester, and M. M. Simon, Immunol. Lett. 36:219-226, 1993). We have now used the latter immune sera to identify new spirochetal structures with relevance for protection from an expression library of the virulent European strain B. burgdorferi ZS7. Here we report the cloning and characterization of a novel lipoprotein, designated pG, the gene for which is located on a 48-kb linear plasmid. Sequence analysis of the pG gene revealed an open reading frame encoding a putative lipoprotein of 196 amino acids with a calculated molecular mass of 22 kDa and a consensus cleavage sequence (Leu-X-Y-Z-Cys) recognized by signal peptidase II. Restriction fragment length polymorphism analyses of pG derived from independent B. burgdorferi isolates from different geographic areas revealed that the gene is species specific, with, however, extensive genotypic heterogeneity. Comparison of the protein sequence of pG with those of other known B. burgdorferi outer surface lipoproteins (OspA to OspF and P27) demonstrated that pG is most related to OspF. Furthermore, the upstream region of pG exhibited extensive sequence homology (> 94%) with the ospEF promoter region. Mouse immune sera to recombinant pG did not recognize a corresponding molecule in lysates of in vitro-propagated ZS7 spirochetes. However, experimental or natural infection of mice with ZS7 resulted in the induction of antibodies with reactivity for pG and the potential to delay the development of clinical arthritis. Together with the finding that sera from Lyme disease patients also contain antibodies to pG, our data suggest that the pG gene is preferentially expressed in the mammal environment.
Constrained optimal framings of curves and surfaces using quaternion Gauss maps (1998)

We propose a general paradigm for computing optimal coordinate frame fields that may be exploited to visualize curves and surfaces. Parallel transport framings, which work well for open curves, generally fail to have desirable properties for cyclic curves and for surfaces. We suggest that minimal quaternion measure provides an appropriate heuristic generalization of parallel transport. Our approach differs from minimal tangential acceleration approaches due to the addition of sliding ring constraints that fix one frame axis, but allow an axial rotational freedom whose value is varied in the optimization process. Our fundamental tool is the quaternion Gauss map, a generalization to quaternion space of the tangent map for curves and of the Gauss map for surfaces. The quaternion Gauss map takes 3D coordinate frame fields for curves and surfaces into corresponding curves and surfaces constrained to the space of possible orientations in quaternion space. Standard optimization tools provide application specific means of choosing optimal, e.g., length- or area-minimizing, quaternion frame fields in this constrained space.
English in the Commonwealth: 6—Nigeria (1963)

English in the Commonwealth: 6—Nigeria Get access P. DRUMMOND THOMPSON P. DRUMMOND THOMPSON English Language Officer, British Council, Nigeria, 1959–62 Search for other works by this author on: Oxford Academic Google Scholar ELT Journal, Volume XVII, Issue 4, July 1963, Pages 152–158, https://doi.org/10.1093/elt/XVII.4.152 Published: 01 July 1963
Virtual asymmetric multiprocessor for interactive performance of consolidated desktops (2014)

This paper presents virtual asymmetric multiprocessor, a new scheme of virtual desktop scheduling on multi-core processors for user-interactive performance. The proposed scheme enables virtual CPUs to be dynamically performance-asymmetric based on their hosted workloads. To enhance user experience on consolidated desktops, our scheme provides interactive workloads with fast virtual CPUs, which have more computing power than those hosting background workloads in the same virtual machine. To this end, we devise a hypervisor extension that transparently classifies background tasks from potentially interactive workloads. In addition, we introduce a guest extension that manipulates the scheduling policy of an operating system in favor of our hypervisor-level scheme so that interactive performance can be further improved. Our evaluation shows that the proposed scheme significantly improves interactive performance of application launch, Web browsing, and video playback applications when CPU-intensive workloads highly disturb the interactive workloads.
2A1-D03 Development of Robot System with Cylindrical Multi-touch Display(Communication Robot) (2011)

This paper describes a research for the mobile robot system which has a cylindrical multi-touch display for human-robot interface device. Using cylindrical multi-touch display, the robot can show information to people and recieve a command by people all-around. This paper shows equipment configuration and design of this robot.
The sensitivity of competitive hybridisation for the detection of mutant p53 alleles in a background of wild type (1995)

Conference Article| February 01 1995 The sensitivity of competitive hybridisation for the detection of mutant p53 alleles in a background of wild type KAREN CARPENTER; KAREN CARPENTER *Department of Surgery, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: This Site PubMed Google Scholar KEVIN MORGAN; KEVIN MORGAN 2Department of Clinical Chemistry, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: This Site PubMed Google Scholar LINDY G. DURRANT; LINDY G. DURRANT *Department of Surgery, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: This Site PubMed Google Scholar JACK D. HARDCASTLE; JACK D. HARDCASTLE *Department of Surgery, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: This Site PubMed Google Scholar NOOR KALSHEKER NOOR KALSHEKER 2Department of Clinical Chemistry, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1995) 23 (1): 129S. https://doi.org/10.1042/bst023129s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation KAREN CARPENTER, KEVIN MORGAN, LINDY G. DURRANT, JACK D. HARDCASTLE, NOOR KALSHEKER; The sensitivity of competitive hybridisation for the detection of mutant p53 alleles in a background of wild type. Biochem Soc Trans 1 February 1995; 23 (1): 129S. doi: https://doi.org/10.1042/bst023129s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1995 Biochemical Society1995 Article PDF first page preview Close Modal You do not currently have access to this content.
Raised circulating tenascin-C in rheumatoid arthritis (2012)

Raised circulating TNC levels are detected in specific inflammatory diseases. Levels are especially high in RA where they may act as a biomarker of bone erosion and a predictor of the effect of infliximab on RA patient joint pain.
Efficacy of beta-lapachone in pancreatic cancer treatment: Exploiting the novel, therapeutic target NQO1 (2005)

NAD(P)H:quinone oxidoreductase (NQO1) is elevated in human pancreatic cancers. We hypothesized that beta-lapachone, a novel 1,2-naphthoquinone with potential antitumor activity in cancer cells expressing elevated levels of NQO1, would induce cytotoxicity in pancreatic cancer cells, wherein this two-electron reductase was recently found elevated. beta-lapachone decreased clonogenic cell survival, metabolic cell viability, and anchorage- independent growth in soft agar. The cytotoxic in vitro effects of beta-lapachone were inhibited with coadministration of dicumarol, a specific inhibitor of NQO1. In preestablished human pancreatic tumor xenografts in nude mice, beta-lapachone demonstrated greater tumor growth inhibition when given intratumorally compared to when complexed with cyclodextrin to increase its bioavailability. Due to the poor prognosis of patients with pancreatic cancer and the limited effectiveness of surgery, chemotherapy, and radiation therapy, treatment regimens based on sound, tumor-specific rationales are desperately need for this disease.
ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues (2018)

High-throughput RNA-sequencing (RNA-seq) technologies provide an unprecedented opportunity to explore the individual transcriptome. Unmapped reads are a large and often overlooked output of standard RNA-seq analyses. Here, we present Read Origin Protocol (ROP), a tool for discovering the source of all reads originating from complex RNA molecules. We apply ROP to samples across 2630 individuals from 54 diverse human tissues. Our approach can account for 99.9% of 1 trillion reads of various read length. Additionally, we use ROP to investigate the functional mechanisms underlying connections between the immune system, microbiome, and disease. ROP is freely available at https://github.com/smangul1/rop/wiki .
Endogenous IGF-I regulates IGF binding protein production in human intestinal smooth muscle cells (2000)

Human intestinal smooth muscle in culture produces insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3, IGFBP-4, and IGFBP-5, which modulate the effects of IGF-I. This study examined the regulation of IGFBP production by endogenous IGF-I. R3-IGF-I, an agonist unaffected by IGFBPs, elicited concentration-dependent increase in growth, measured by [(3)H]thymidine incorporation, and production of IGFBP-3, IGFBP-4, and IGFBP-5, measured by Western blot. Antagonists of the IGF-I receptor, IGF-I Analog or monoclonal antibody 1H7, elicited concentration-dependent inhibition of growth and decrease in IGFBP-3, IGFBP-4, and IGFBP-5 production, implying that endogenous IGF-I stimulated growth and IGFBP production. R3-IGF-I-induced increase in IGFBP-3, IGFBP-4, and IGFBP-5 production was partially inhibited by a mitogen-activated protein (MAP) kinase or a phosphatidylinositol-3-kinase (PI 3-kinase) inhibitor and abolished by the combination. We conclude that endogenous IGF-I stimulates growth and IGFBP-3, IGFBP-4, and IGFBP-5 production in human intestinal smooth muscle cells. Regulation of IGFBP production by IGF-I is mediated by activation of distinct MAP kinase and PI 3-kinase pathways, the same pathways through which IGF-I stimulates growth.
Reducing the cognitive complexity of business process models (2009)

Current research on the quality of business process models mostly discusses the quality of a model mainly in terms of correctness of its behaviour. In this paper, we discuss another perspective: Because the main purpose of business process models is to be read and understood by humans, understandability is an important requirement. We present some patterns for improving the understandability by reducing the cognitive load. By applying these patterns to a repository of almost 1000 models, we have been able to improve the comprehensibility of several models.
The Action of Phosgene on Acetone<sup>1</sup> (1934)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Action of Phosgene on Acetone1Maryan P. MatuszakCite this: J. Am. Chem. Soc. 1934, 56, 9, 2007Publication Date (Print):September 1, 1934Publication History Published online1 May 2002Published inissue 1 September 1934https://pubs.acs.org/doi/10.1021/ja01324a504https://doi.org/10.1021/ja01324a504research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intensional Summaries as Cooperative Responses in Dialogue: Automation and Evaluation (2008)

Despite its long history, and a great deal of research producing many useful algorithms and observations, research in cooperative response generation has had little impact on the recent commercialization of dialogue technologies, particularly within the spoken dialogue community. We hypothesize that a particular type of cooperative response, intensional summaries, are effective for when users are unfamiliar with the domain. We evaluate this hypothesis with two experiments with cruiser, a DS for in-car or mobile users to access restaurant information. First, we compare cruiser with a baseline system-initiative DS, and show that users prefer cruiser. Then, we experiment with four algorithms for constructing intensional summaries in cruiser, and show that two summary types are equally effective: summaries that maximize domain coverage and summaries that maximize utility with respect to a user model. 1
Evaluation of hydrojacking and hydrofracturing behavior in Aghajari formation (Gotvand dam site foundation), Iran (2011)

Regarding the construction of large dams, definition of hydraulically and hydro mechanical conditions of rock mass is necessary. This paper summarizes the results and evaluation of hydraulic jacking and hydraulic fracturing tests conducted in Aghajari formation in different depths. Lugeon testing was carried out in selected boreholes in order to study the groundwater characteristics of the Aghajari formation. The results of sealing grouting and consolidation test grouting have been assessed. Hydro jacking phenomenon has the best performance among the phenomena of Aghajari formation during grouting. In addition, the hydrofracturing pressure especially in first stages has been evaluated. On the basis of these behaviors and their interpretations, appreciable changes have been observed in grouting pressures and designed mixes. However, the changes were considered for optimizing the grouting pressure and water tightness design, as well as the economics.

	 

	Key word: Hydraulic fractures, SPI, P-Q diagrams, Gotvand Dam, Aghajari formation.
A Simple Method for Quantifying Functional Selectivity and Agonist Bias (2011)

Activation of seven-transmembrane (7TM) receptors by agonists does not always lead to uniform activation of all signaling pathways mediated by a given receptor. Relative to other ligands, many agonists are "biased" toward producing subsets of receptor behaviors. A hallmark of such "functional selectivity" is cell type dependence; this poses a particular problem for the profiling of agonists in whole cell test systems removed from the therapeutic one(s). Such response-specific cell-based variability makes it difficult to guide medicinal chemistry efforts aimed at identifying and optimizing therapeutically meaningful agonist bias. For this reason, we present a scale, based on the Black and Leff operational model, that contains the key elements required to describe 7TM agonism, namely, affinity (K(A) (-1)) for the receptor and efficacy (τ) in activating a particular signaling pathway. Utilizing a "transduction coefficient" term, log(τ/K(A)), this scale can statistically evaluate selective agonist effects in a manner that can theoretically inform structure-activity studies and/or drug candidate selection matrices. The bias of four chemokines for CCR5-mediated inositol phosphate production versus internalization is quantified to illustrate the practical application of this method. The independence of this method with respect to receptor density and the calculation of statistical estimates of confidence of differences are specifically discussed.
Intent specifications: an approach to building human-centered specifications (2000)

This paper examines and proposes an approach to writing software specifications, based on research in systems theory, cognitive psychology and human-machine interaction. The goal is to provide specifications that support human problem solving and the tasks that humans must perform in software development and evolution. A type of specification, called intent specifications, is constructed upon this underlying foundation.
<title>User-configurable data acquisition systems</title> (1996)

Over the past three years we have developed a suite of software tools to support the use of systems with dynamically reconfigurable hardware by scientists and engineers who are not skilled hardware designers. A typical application for our system is the support software for a reconfigurable data acquisition card consisting of a fixed analog section and a configurable digital section built from one or more field programmable gate arrays (FPGAs), static RAM chips, and, perhaps, a dedicated processor. In this paper we discuss our software tools, the prototype data acquisition hardware that we have developed, and an example application.
Active Structural Acoustic Control of Aircraft Cabin Noise Using Optimized Actuator Arrays - Laboratory Tests (1995)

This paper presents the results of aircraft cabin noise reduction tests conducted in a full scale, furnished aft cabin test section of a DC-9 aircraft, using active structural acoustic co11trol (ASAC) techniques. The active control sources consisted of a set of 34 piezoceramic actuators bonded to the fuselage skin, combined into 16 groups (since the system controller has 16 output drive channels). The purpose of these tests was to compare the reductions obtained using a baseline actuator configuration with several optimized configurations, for harmonic excitation of the structure at several frequencies using acoustic and/or vibration sources. The baseline configuration was guided by the modal characteristics of the acoustic cavity and fuselage structure. The optimized configurations were determined using a numerical optimization routine and clustering algorithm to a suitably defined cost function. The tests showed that significant increases in noise reduction were achieved for several, but not all, excitation cases.
Modified atomic force microscopy cantilever design to facilitate access of higher modes of oscillation (2006)

The detection of higher modes of oscillation in atomic force microscopy can provide additional information on sample properties. However, the limited bandwidth of the photodiode in the beam deflection detection technique often limits the detectable frequency range. We present a novel cantilever design, which allows lowering the frequency of higher modes of oscillation, maintaining the frequency of the fundamental resonance. Simulations by finite element methods show that the ratio between the second mode and the fundamental resonance frequency can be adjusted between 2 and 10, compared to 6.3 for the regular rectangular cantilever design. Even stronger changes are observed for the third oscillation mode, corresponding to a torsional cantilever oscillation. Cantilevers with modified geometry were fabricated using silicon micromachining processes and subsequently tested, confirming the results from the simulation.
<i>Agrobacterium-</i>transformed rice plants expressing synthetic<i>cryIA(b)</i>and<i>cryIA(c)</i>genes are highly toxic to striped stem borer and yellow stem borer (1998)

Over 2,600 transgenic rice plants in nine strains were regenerated from >500 independently selected hygromycin-resistant calli after Agrobacterium-mediated transformation. The plants were transformed with fully modified (plant codon optimized) versions of two synthetic cryIA(b) and cryIA(c) coding sequences from Bacillus thuringiensis as well as the hph and gus genes, coding for hygromycin phosphotransferase and beta-glucuronidase, respectively. These sequences were placed under control of the maize ubiquitin promoter, the CaMV35S promoter, and the Brassica Bp10 gene promoter to achieve high and tissue-specific expression of the lepidopteran-specific delta-endotoxins. The integration, expression, and inheritance of these genes were demonstrated in R0 and R1 generations by Southern, Northern, and Western analyses and by other techniques. Accumulation of high levels (up to 3% of soluble proteins) of CryIA(b) and CryIA(c) proteins was detected in R0 plants. Bioassays with R1 transgenic plants indicated that the transgenic plants were highly toxic to two major rice insect pests, striped stem borer (Chilo suppressalis) and yellow stem borer (Scirpophaga incertulas), with mortalities of 97-100% within 5 days after infestation, thus offering a potential for effective insect resistance in transgenic rice plants.
Lessons from building static analysis tools at Google (2018)

For a static analysis project to succeed, developers must feel they benefit from and enjoy using it.