gebhart/patrepeval huggingface dataset:
Probing Pathways of Neuroendocrine Regulation With Voltammetric Microelectrodes (1987)

The endocrine system represents a complex communications and control network operating throughout the entire organism for purposes of maintaining homeostasis and promoting continuance of the species. The informational units, or intercellular messengers, of this system encompass a diverse range of peptide and protein molecules (hypophysiotropic substances, growth factors, hormones) that are secreted in an episodic fashion directly into the extracellular fluid or circulatory system. Actions of these messengers may be limited to the secretory cell itself (autocrine), to neighboring cells (paracrine), or to distant target cells possessing appropriate receptors. Both synthetic and secretory activities of endocrine cells are tightly regulated by feedback loops and by central nervous system afferent input that is superimposed via a multiplicity of neurotransmitter pathways.
Methylchloropolysilanes and derivatives prepared from the redistribution of methylchlorodisilanes (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethylchloropolysilanes and derivatives prepared from the redistribution of methylchlorodisilanesRonald H. Baney, John H. Gaul Jr., and Terrence K. HiltyCite this: Organometallics 1983, 2, 7, 859–864Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/om50001a014https://doi.org/10.1021/om50001a014research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
1-Methyl-1-phenylphosphiranium triflate: synthesis, structure and reactivity (1995)

D. C. R. Hockless, M. A. McDonald, M. Pabel and S. B. Wild, J. Chem. Soc., Chem. Commun., 1995, 257 DOI: 10.1039/C39950000257
Li0.44MnO2: an intercalation electrode with a tunnel structure and excellent cyclability (1998)

Li0.44MnO2 possesses a complex tunnel structure composed of sheets of edge-sharing MnO6 octahedra and columns of edge-sharing MnO5 square pyramids both lying parallel to the c axis of the orthorhombic unit cell (space group Pbam). The sheets and columns corner share thus defining two types of tunnels. The smaller of these contains one Li+ ion site and the larger two pairs of Li+ sites. There are no less than five crystallographically distinct Mn sites. The lithium content of the host has been varied by chemical and electrochemical intercalation/deintercalation over the range LixMnO2 ; 0.25<x<0.63. The associated change in the lithium site occupancies has been determined by a combination of powder neutron diffraction and electrochemical measurements. The structure demonstrates a remarkable ability to cycle lithium with no perceptible loss of capacity when cycled over the range 2.8–3.6 V vs. Li+(1 m)/Li, at 0.5 mA cm–2 corresponding to a capacity of 85–90 mA h g–1 .
Effects of the antioxidant butylated hydroxytoluene (BHT) on retinal degeneration induced transplacentally by a single low dosage of n‐methyl‐N‐nitrosourea (MNU) (1988)

A 1 mg/kg dose of the DNA alkylating agent, N-methyl-N-nitrosourea (MNU), when administered on day 16 of gestation provokes a progressive retinal degeneration in CD-1 albino mice reared under standard fluorescent lighting conditions (12 hr light: 12 hr dark); this degeneration begins at about 4 weeks post-natally and worsens with age. It is accelerated by constant fluorescent light exposure but is retarded greatly by constant darkness, suggesting the importance of secondary insults in the post-natal period for development of the degenerative disease. To determine whether the secondary photochemical damage might be specifically blocked, MNU-exposed and control animals in the present study were fed an antioxidant-enriched diet of Purina mouse chow supplemented with 0.75% butylated hydroxytoluene (BHT). A second group of MNU-exposed and control animals were fed a non-BHT supplemented standard Purina mouse chow diet. Systematic measurements of the number of rows of photoreceptor cell nuclei, the thickness of the inner/outer segment layer, and the thickness of the whole retina were made, to quantify and degenerative changes in animals 2, 4, 6, and 8 weeks of age. By 8 weeks, retinas of BHT-fed, MNU-exposed animals were significantly thicker and had more rows of photoreceptor cell nuclei than regular-diet, MNU-exposed animals. Moreover, the retinas of BHT-fed animals, both for MNU-exposed and controls, demonstrated sporadic morphologic changes in the form of circular configurations composed of ganglion cells, arcades of nuclear and plexiform layers, and, in one control animal, a hyperplastic nodule. These experiments suggested that MNU-induced retinal degeneration may be retarded by a BHT-enriched diet; however, continuous high doses of this compound pre- and postnatally may induce other retinal abnormalities.
A Generalized Language Model as the Combination of Skipped n-grams and Modified Kneser Ney Smoothing (2014)

Rene Pickhardt, Thomas Gottron, Martin Körner, Paul Georg Wagner, Till Speicher, Steffen Staab. Proceedings of the 52nd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). 2014.
A frugal approach to reduce RCU grace period overhead (2018)

Grace period computation is a core part of the Read-Copy-Update (RCU) synchronization technique that determines the safe time to reclaim the deferred objects' memory. We first show that the eager grace period computation employed in the Linux kernel is appropriate only for enterprise workloads such as web and database servers where a large amount of reclaimable memory awaits the completion of a grace period. However, such memory is negligible in High-Performance Computing (HPC) and mostly idling environments due to limited OS kernel activity. Hence an eager approach is not only futile but also detrimental as the CPU cycles consumed to compute a grace period leads to jitter in HPC and frequent CPU wake-ups in idle environments.
Dynamical Control of Terahertz Metamaterial Resonance Response Using Bimaterial Cantilevers (2014)

Abstract — In this work, we report a novel method for the dynamical control of the resonant electrical response of terahertz (THz) metamaterials. Our approach is based on planar arrays of split-ring resonators (SRRs) coupled with microfabrication methods to create a bimaterialcantilever-based THz metamaterial switch. Our device exhibits a tunable resonant response centered at 0.75 THz and operates by modifying or shorting the SRR capacitive gap with the bimaterial cantilevers. These results demonstrate the potential of bimaterial-cantilever-based MMs for creating THz devices including, as examples, switches, dynamic filters, and phase shifters. 1.
siRNA-mediated off-target gene silencing triggered by a 7 nt complementation (2005)

A growing body of evidence suggests that siRNA could generate off-target effects through different mechanisms. However, the full impact of off-target gene regulation on phenotypic induction and accordingly on data interpretation in the context of large-scale siRNA library screen has not been reported. Here we report on off-target gene silencing effects observed in a large-scale knockdown experiment designed to identify novel regulators of the HIF-1 pathway. All of the three 'top hits' from our screen have been demonstrated to result from off-target gene silencing. Two of the three 'siRNA hits' were found to directly trigger down-regulation of hif-1alpha mRNA through a 7 nt motif, AGGCAGT, that is present in both the hif-1alpha mRNA and the siRNAs. Further analysis revealed that the generation of off-target gene silencing via this 7 nt motif depends on the characteristics of the target mRNA, including the sequence context surrounding the complementary region, the position of the complementary region in the mRNA and the copy number of the complementary region. Interestingly, the off-target siRNA against hif-1alpha was also shown to trigger mRNA degradation with high probability of other genes that possess multiple copies of the AGGCAGT motif in the 3'-untranslated region. Lessons learned from this study will be a valuable asset to aid in designing siRNAs with more stringent target selectivity and improving 'hits-follow-up' strategies for future large-scale knockdown experiments.
The physicochemical approach to drug design and discovery (QSAR) (1981)

Abstract The study of physicochemical parameters to correlate mathematically chemical structure with biological activity induced by sets of congeneric drugs is now generally referred to as QSAR (quantitative structure‐activity relationships). The ways in which the QSAR paradigm are developing are becoming more varied and complex. Many kinds of parameters are under study in many different groups; various types of mathematical models have been proposed and are being evaluated. Drug researchers are turning more to enzyme modulation to control various biological processes. It is the study of enzyme‐ligand reactions of enzymes whose x‐ray crystallographic structure is known that affords us the means for developing a deeper understanding of QSAR and, at the same time, enhancing our ability to make drugs more selective for various forms of a given enzyme. The union of x‐ray crystallography, moleculargraphics, and QSAR is one of the most exciting new areas of drug development. This report is an introduction to how QSAR is being used to gain insight into the interaction of drugs with macromolecules and macromolecular systems.
The Modelling of Information Processing on Chinese VDT. (1987)

From the fungus Stereum hirsutum have been isolated and identified two new epidioxysterols 1, 4, together with two known ones 2 and 3. Their structures were elucidated on the basis of spectroscopic analysis and chemical reactions. Epidioxysterols 1-4 have been shown to possess a significant activity against Mycobacterium tuberculosis.
Microwave generation in an optical breakdown plasma created by modulated laser radiation (1990)

It was established that when laser radiation, intensity modulated at a frequency of 2.2 GHz, interacted with an optical breakdown plasma which it had created, a microwave component appeared in the thermal emf of the plasma. The amplitude of the microwave thermal emf reached 0.7 V for a laser radiation intensity of 6 GW/cm2. Laser radiation with λL = 1.06 μm was converted to the microwave range with λmω = 13 cm in the optical breakdown plasma. A microwave signal power of ~ 0.5 W was obtained from a laser power of ~ 5 MW.
Nelfilcon A, a New Material for Contact Lenses (1999)

The synthesis and the purification of a new photo-crosslinkable poly(vinyl alcohol), Nelfilcon A, is briefly reviewed in this paper. Methods for the attachment of different functional groups to the polymer backbone are described. From the Nelfilcon A macromer, Focus® Dailies™ contact lenses are produced with a new production technology.
Review: <i>An Annotated Bibliography of Mexican Ferns</i>, by George N. Jones (1967)

Book Review| October 01 1967 Review: An Annotated Bibliography of Mexican Ferns, by George N. Jones An Annotated Bibliography of Mexican FernsGeorge N. Jones Charles T. Mason,, Jr. Charles T. Mason,, Jr. Search for other works by this author on: This Site PubMed Google Scholar The American Biology Teacher (1967) 29 (7): 568–569. https://doi.org/10.2307/4441834 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Charles T. Mason,; Review: An Annotated Bibliography of Mexican Ferns, by George N. Jones. The American Biology Teacher 1 October 1967; 29 (7): 568–569. doi: https://doi.org/10.2307/4441834 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Biology Teacher Search This content is only available via PDF. Copyright 1967 The National Association of Biology Teachers Article PDF first page preview Close Modal You do not currently have access to this content.
Effect of femoral offset on range of motion and abductor muscle strength after total hip arthroplasty (1995)

At a minimum of one year after operation, we studied 64 patients with 86 total hip arthroplasties (THA) by standard anteroposterior hip and pelvic radiographs and measurement of range of motion and of isometric abduction strength. The femoral offset correlated positively with the range of abduction (p = 0.046). Abduction strength correlated positively with both femoral offset (p = 0.0001) and the length of the abductor lever arm (p = 0.005). Using multiple regression, abduction strength correlated with height (p = 0.017), gender (p = 0.0005), range of flexion (p = 0.047) and the abductor lever arm (p = 0.060). Our findings suggest that greater femoral offset after THA allows both an increased range of abduction and greater abductor strength.
Characterisation of the Vasculature Within a Murine Adenocarcinoma Growing in Different Sites to Evaluate the Potential of Vascular Therapies (1995)

Numerous vaso-active agents can affect vasculature in experimental solid tumours growing subcutaneously (s.c.), but these models are unlikely to reflect the vasculature of metastatic disease in man. The present study describes a murine orthotopic colon tumour which metastasises to the liver. Morphology and vascular pattern of caecal tumours is similar to s.c. tumours. Vascular occlusion caused by intravenous (i.v.) noradrenaline (NA) (160 micrograms kg-1) and hydralazine (HDZ) (10 mgkg-1) was 32% and 59% respectively for the caecal tumours compared with 35% and 78% for s.c. tumours. Significant morphological differences were seen between liver metastases and systemic deposits produced by i.v. inoculation of tumour cells. Liver metastases following orthotopic transplantation contained functional vasculature but no significant occlusion was seen with NA or HDZ. The vascular development and morphological appearance of secondary disease resulting from orthotopic implantation suggests that this would be a useful model for the study of agents that act either by vascular or anti-angiogenic mechanism.
Multicriteria Similarity-Based Anomaly Detection Using Pareto Depth Analysis (2015)

We consider the problem of identifying patterns in a data set that exhibits anomalous behavior, often referred to as anomaly detection. Similarity-based anomaly detection algorithms detect abnormally large amounts of similarity or dissimilarity, e.g., as measured by the nearest neighbor Euclidean distances between a test sample and the training samples. In many application domains, there may not exist a single dissimilarity measure that captures all possible anomalous patterns. In such cases, multiple dissimilarity measures can be defined, including nonmetric measures, and one can test for anomalies by scalarizing using a nonnegative linear combination of them. If the relative importance of the different dissimilarity measures are not known in advance, as in many anomaly detection applications, the anomaly detection algorithm may need to be executed multiple times with different choices of weights in the linear combination. In this paper, we propose a method for similarity-based anomaly detection using a novel multicriteria dissimilarity measure, the Pareto depth. The proposed Pareto depth analysis (PDA) anomaly detection algorithm uses the concept of Pareto optimality to detect anomalies under multiple criteria without having to run an algorithm multiple times with different choices of weights. The proposed PDA approach is provably better than using linear combinations of the criteria, and shows superior performance on experiments with synthetic and real data sets.
Polarization scrambling using a short piece of high-birefringence optical fiber and a multifrequency laser diode (1994)

Describes a technique for avoiding system performance degradation and outages in an optical fiber system due to state of polarization mismatch between signal and polarization-sensitive system components. The technique uses a short piece of high-birefringence fiber and a multifrequency laser to create a depolarized source that can be used to transmit data without fading.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Neuroleptic Medications in the Treatment of Schizophrenia (1997)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Activation of macrophages for enhanced release of superoxide anion and greater killing of Candida albicans by injection of muramyl dipeptide. (1980)

The adjuvant muramyl dipeptide (MDP) has been shown to affect a number of macrophage functions in vitro. We studied the effect of subcutaneous injection of MDP into mice. Cultured peritoneal macrophages from treated mice displayed increased spreading, total cell protein, and specific activity of beta-glucosaminidase a constituent of macrophage lysosomes, and of lactate dehydrogenase. Generation of superoxide anion (O2-) by MDP-treated macrophages stimulated by contact with phorbol myristate acetate was enhanced by over fivefold to levels achieved by macrophages from bacillus Calmette-Guérin-infected mice. The enhancement in stimulated O2- release was noted by 1 h after injection of MDP, peaked by 3 h, and remained high for at least 48 h. Priming for enhancement of O2- release by MDP was similar in athymic nude mice and in normal littermates, suggesting that mature T lymphocytes are not involved in this MDP effect. Priming for enhanced stimulated O2- release, and morphologic and enzymic changes, were not achieved by injection of the D-D stereoisomer of MDP. Phagocytosis of Candida albicans was only slightly greater by macrophages from mice give MDP, but MDP-stimulated cells killed two times more C. albicans in vitro than did cells from untreated animals. When MDP was given 18 h before, simultaneously with, or 24 h after lethal infectious challenge with C. albicans, treated mice were protected compared with controls. These results suggest that injection of MDP effectively and rapidly activates macrophages in the recipient animal. This agent should serve as an important probe of macrophage physiology and, perhaps ultimately, as a means of enhancing host defense in humans.
A synthetic <i>Escherichia coli</i> predator–prey ecosystem (2008)

We have constructed a synthetic ecosystem consisting of two Escherichia coli populations, which communicate bi-directionally through quorum sensing and regulate each other's gene expression and survival via engineered gene circuits. Our synthetic ecosystem resembles canonical predator-prey systems in terms of logic and dynamics. The predator cells kill the prey by inducing expression of a killer protein in the prey, while the prey rescue the predators by eliciting expression of an antidote protein in the predator. Extinction, coexistence and oscillatory dynamics of the predator and prey populations are possible depending on the operating conditions as experimentally validated by long-term culturing of the system in microchemostats. A simple mathematical model is developed to capture these system dynamics. Coherent interplay between experiments and mathematical analysis enables exploration of the dynamics of interacting populations in a predictable manner.
A Low-Powered 4-Channel Physiological Radio Telemetry System for Use in Surgical Patient Monitoring (1976)

A series of 4-channel physiological radio telemetry systems with long battery life and dc response capability have been designed and built. Twenty-one of these systems are used in the operating rooms on patients undergoing surgery at the Duke University Medical Center. The features of these systems are described.
Synthesis of the Mast Cell Degranulating (MCD) Peptide from Bee Venom (1979)

Potential value in the therapy of rheumatism and other inflammation processes could attach to the MCD peptide from bee venom if it were available in larger quantities. The peptide consists of 22 amino acids and contains two disulfide bridges. Its first total synthesis has now been accomplished.
Vision-based localization of a quad-rotor system (2012)

This paper presents the localization of a quad-rotor system using a camera for indoor application. To localize the quad-rotor system with a camera, several practical issues are addressed. Firstly, radially distorted images by a convex lens should be corrected. Secondly, markers are used to detect the position and the heading angle of the system. Lastly, position with respect to different heights should be calibrated. Experimental studies confirm the localization based on a vision system.
Chemical composition, cytotoxicity and antioxidant activities of the essential oil from the leaves of Citrus aurantium L. (2011)

The species of the genus Citrus (Rutaceae) have been widely used in traditional medicine. In this study, the essential oil was extracted from the leaves of Citrus aurantium and its cytotoxicity effect on six tumor cell lines and a normal cell line was studied. Furthermore, antioxidant potential of the oil was tested by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay, hydrogen peroxide scavenging and reducing antioxidant power methods. The composition of the essential oil was also analyzed by GC–MS. Results indicate 41 components that represented 97.81% of the total oil. The major components were limonene, linalool and trans-beta-ocimene. In addition, the essential oil also exhibited strong antioxidant activity. The IC50 of the oil in DPPH assay, H2O2 scavenging and reducing antioxidant power were 1040 ± 0.9, 140 ± 1.5 and 1580 ± 1.03 µg /ml, respectively. The essential oil also had marked cytotoxicity against the all tumor cell lines, with the highest activity on Jurkat and HL60.

	 

	Key words: Citrus aurantium, essential oil, chemical composition, cytotoxicity, antioxidant effect.
The Last Frontier: Market Creation in Conflict Zones, Deep Rural Areas, and Urban Slums (2010)

By operating in war zones, urban slums, and deep rural areas, companies could not only achieve growth and profits, but could also improve the economic and social conditions of these impoverished regions. Yet how can a company operate in areas with unstable security, poor infrastructure, and little or no formal legal frameworks in place? To do so successfully, companies need to go beyond transactional alliances or legalistic business partnerships with local partners. Instead, they need to develop community buy-in and long-term personal relationships based on trust with “unorthodox” local inhabitants—the ones offering them security and protection rather than technology and business assets. Such deep social embeddedness is not cost-free. To prevent it from derailing their success, companies need to nurture and grow their local partners beyond their specific needs.