gebhart/patrepeval huggingface dataset:
Autoimmune hemolytic anemia following T cell-depleted allogeneic bone marrow transplantation. (1996)

The development of immune-mediated hemolytic anemia is a well-recognized complication after allogeneic bone marrow transplantation (BMT). The majority of reported cases, however, have been alloimmune in origin due to ABO or minor red blood cell antigen incompatibilities between the donor and recipient. In this study, we report seven adult patients who developed autoimmune hemolytic anemia (AIHA) between June 1985 and January 1993. These patients were identified from a total of 236 adult patients who received T cell-depleted (TCD) grafts as graft-versus-host disease (GVHD) prophylaxis. The onset of AIHA was at a median of 10 months (range 7-25 months) post-transplant and occurred in 5% of all patients transplanted with TCD grafts who survived at least 6 months. Six patients had a warm reacting autoantibody, while one patient had a cold-reacting antibody with a thermal amplitude up to 30 degrees C. All were receiving immunosuppressive treatment for GVHD at the time of diagnosis. Initial treatment in all patients consisted of steroids. Three of the seven had a partial response while the four remaining patients failed to respond to corticosteroids. Splenectomy was performed in three patients with two partial responses. Four patients were treated with additional therapeutic interventions, including plasmapheresis, immunoglobulin infusions, staphylococcus protein A column, or other immunosuppressive agents. In five cases, erythropoietin was administered as adjunctive treatment to maintain adequate hematocrit levels. Two patients are presently in complete remission after prolonged courses of steroids, while a third patient has compensated hemolysis requiring low-dose steroids. Four patients died due to either infectious complications or disseminated intravascular coagulation secondary to cold agglutinin disease. These data indicate that AIHA is a clinically significant and not infrequent complication in allogeneic marrow transplant recipients. The response to conventional treatment is generally unsatisfactory as even patients who ultimately remit require prolonged courses of immunosuppressive therapy.
Reweighting strategies in seismic deconvolution (1997)

Reweighting strategies have been widely used to diminish the influence of outliers in inverse problems. In a similar fashion, they can be used to design the regularization term that must be incorporated to solve an inverse problem successfully. Zero-order quadratic regularization, or damped least squares (pre-whitening) is a common procedure used to regularize the deconvolution problem. This procedure entails the definition of a constant damping term which is used to control the roughness of the deconvolved trace. In this paper I examine two different regularization criteria that lead to an algorithm where the damping term is adapted to successfully retrieve a broad-band reflectivity. Synthetic and field data examples are used to illustrate the ability of the algorithm to deconvolve seismic traces.
Elucidation of the Reaction Mechanism for the Palladium‐Catalyzed Synthesis of Vinyl Acetate (2005)

Finding the right pathway: Reaction of isotopomers of ethylene with acetate species (see scheme) adsorbed on a Pd(111) surface in ultrahigh vacuum has shown that vinyl acetate is produced by insertion of ethylene into the acetate species to form an acetoxyethyl intermediate, which decomposes by β-hydride elimination to yield vinyl acetate.
Higher Prevalence of Elevated Albumin Excretion in Youth With Type 2 Than Type 1 Diabetes (2007)

Youth with type 2 diabetes have a higher prevalence of elevated ACR than youth with type 1 diabetes, in an association that apparently does not completely depend on age, duration of diabetes, race/ethnicity, sex, level of glycemic control, or features of insulin resistance.
Determination ofin vitro permeability of drug candidates through a Caco-2 cell monolayer by liquid chromatography/tandem mass spectrometry (2000)

Studying the permeability of compounds across a Caco-2 cell monolayer is an established in vitro model to screen for oral absorption and to evaluate the mechanism of transport. This assay can also be used to evaluate compounds as potential P-glycoprotein substrates and/or inhibitors. The traditional methods of sample analysis (high-performance liquid chromatography (HPLC) with a UV or fluorescence detector) limit the throughput and sensitivity of this assay. Data are presented here describing the use of liquid chromatography/tandem mass spectrometry (LC/MS/MS) for the analysis of samples derived from the Caco-2 cell studies. During the analysis an automatic switching valve was used to divert the flow from the HPLC column to waste for the first minute, preventing the early eluting salts from entering and contaminating the LC/MS interface. This approach allows the rapid and accurate determination of drug transport across the Caco-2 cell monolayer. The high sensitivity and specificity of LC/MS/MS make this technique an ideal candidate for the low concentration and high throughput routine analysis of Caco-2 cell solutions, especially if multiple compounds are administered and analyzed simultaneously. Thus, the use of LC/MS/MS will increase the value of the Caco-2 cell assay as an in vitro screening tool.
Risk of Hepatocellular Cancer in HCV Patients Treated With Direct-Acting Antiviral Agents (2017)

Among patients treated with DAA, SVR was associated with a considerable reduction in the risk of HCC. We did not find any evidence to suggest that DAAs promote HCC. However, in patients with SVR, the absolute risk of HCC remained high in patients with established cirrhosis. These patients should be considered for ongoing HCC surveillance.
Trends of the Portrayal of Yahweh in the Hebrew Bible (2014)

Kenneth Price explores trends of the portrayal of Yahweh in the Hebrew bible in this essay written for the Integrated Writing course ENG 2040: Great Books, Bible and Western Culture, taught by Dr. Heidi Wendt at Wright State University.
ANDROID IN PRACTICE (2011)

SummaryAndroid in Practice is a treasure trove of Android goodness, with over 90 tested, ready-to-use techniques including complete end-to-end example applications and practical tips for real world mobile application developers. Written by real world Android developers, this book addresses the trickiest questions raised in forums and mailing lists. Using an easy-to-follow problem/solution/discussion format, it dives into important topics not covered in other Android books, like advanced drawing and graphics, testing and instrumentation, building and deploying applications, and using alternative languages. About the BookIt's not hard to find the information you need to build your first Android app. Then what? If you want to build real apps, you will need some how-to advice, and that's what this book is about.Android in Practice is a rich source of Android tips, tricks, and best practices, covering over 90 clever and useful techniques that will make you a more effective Android developer. Techniques are presented in an easy-to-read problem/solution/discussion format. The book dives into important topics like multitasking and services, testing and instrumentation, building and deploying applications, and using alternative languages. What's InsideTechniques covering Android 1.x to 3.x Android for tablets Working with threads and concurrency Testing and building Using location awareness and GPS Styles and themesAnd much more!This book requires a working knowledge of Java, but no prior experience with Android is assumed. Source Code can be found at https://code.google.com/p/android-in-practice/ Table of ContentsPART 1 BACKGROUND AND FUNDAMENTALS Introducing AndroidAndroid application fundamentalsManaging lifecycle and state PART 2 REAL WORLD RECIPES Getting the pixels perfect Managing background tasks with Services Threads and concurrency Storing data locally Sharing data between apps HTTP networking and web services Location is everything Appeal to the senses using multimedia 2D and 3D drawing PART 3 BEYOND STANDARD DEVELOPMENT Testing and instrumentation Build management Developing for Android tablets
Mass Spectra of 7H-Thiazolo[3, 2-a]Pyridine Derivatives (1978)

Mass spectra of 7H-thiazolo[3, 2-a]pyridine derivatives were measured by electronimpact ionization mass spectrometry. The substituents on the phenyl group were H, p-CH3, p-OCH3, p-Cl, p-NO2. The methyl or ethyl esters were also examined. The fragmentation patterns were deduced with the aid of the shift of the peaks by substituted groups and by deuterated derivatives. And they were confirmed by metastable peaks. Substituent effect of the phenyl groups on the fragmentation was only observed in the change of intensity of fragment ions, but not observed as the change of fragmentation pathway. On the other hand, fragmentation pathway was changed by the ester groups.
A regression model for forecasting microwave radio fading at Palmetto, GA (1986)

Refractive fading degrades telecommunications transmissions on microwave radio systems. Since fading occurrence is highly variable from one night to the next, forecasts of the probability of fading occurring at a given location on the upcoming night would be useful for reducing the adverse impact of fading on transmission performance. In this work logistic regression analysis was used to develop an empirical formula for forecasting refractive fading probability from meteorological parameters forecast by the National Weather Service's numerical forecast models. The formula was developed using 40 months of daily meteorological and fading measurements collected near Palmetto, GA. The performance of the method was evaluated using eight and one-half months of meteorological forecast data. For days when fading was forecast to be relatively unlikely (0-40 percent probability), 90 percent of those days experienced less than 3 s of fading below -20 dB. For days when fading was forecast to be relatively likely (80-100 percent probability), 75 percent of those days experienced more than 3 s of fading below - 20 dB. These results demonstrate the feasibility of forecasting microwave refractive fading a day in advance.
Efficacy of novel hybrid powders to quench body malodors (1990)

A hybrid powder consisting of a spherical resin core, with its surface uniformly covered with either zinc oxide or aluminum chlorohydrate, was developed to quench offensive body odors. This hybridization technique nables us to overcome some of the aesthetic shortcomings that deodorizing actives possess, without sacrificing any deodorizing efficacy. Improvement in powder texture of zinc oxide and aluminum chlorohydrate when hybridized with spherical polyethylene powder is demonstrated by applying them directly to skin and also by measuring their coefficients of kinetic friction. The effect of hybridization on deodorizing efficacy was also investigated by headspace gas chromatography.
Equilibrium model for ion exchange between multivalent cations and zeolite‐A in a molten salt (2006)

Abstract A two‐site equilibrium model that previously only accommodated monovalent cations has been extended to include divalent and trivalent cations for ion exchange between zeolite‐A and molten chloride salts, a process being considered for concentrating nuclear fission products into high level waste forms. Equilibrium constants were determined by fitting the model to equilibrium data sets for ion exchange between zeolite‐A and Cs ternary salt (CsCl‐LiCl‐KCl), Rb ternary salt (RbCl‐LiCl‐KCl), Na ternary salt (NaCl‐LiCl‐KCl), Sr ternary salt (SrCl 2 ‐LiCl‐KCl), and U ternary salt (UCl 3 ‐LiCl‐KCl). The results reveal a good fit between the experimental data sets and the model. The two ion exchange sites, framework sites and occluded sites, demonstrate different relative selectivities for the cations. It was found that Sr 2+ is the preferred cation in the ion exchange site, and Cs + is the preferred cation in the occlusion site. Meanwhile, Li + has the highest combined selectivity when both ion exchange and occlusion sites are considered. Interestingly, divalent and trivalent species are more preferred in the ion exchange site than the monovalent species with the exception of Li + . © 2006 American Institute of Chemical Engineers AIChE J, 2006
A consensus sequence for binding of Lrp to DNA (1995)

Lrp (leucine-responsive regulatory protein) is a major regulatory protein involved in the expression of numerous operons in Escherichia coli. For ilvIH, one of the operons positively regulated by Lrp, Lrp binds to multiple sites upstream of the transcriptional start site and activates transcription. An alignment of 12 Lrp binding sites within ilvIH DNA from two different organisms revealed a tentative consensus sequence AGAAT TTTATTCT (Q. Wang, M. Sacco, E. Ricca, C.T. Lago, M. DeFelice, and J.M. Calvo, Mol. Microbiol. 7:883-891, 1993). To further characterize the binding specificity of Lrp, we used a variation of the Selex procedure of C. Tuerk and L. Gold (Science 249:505-510, 1990) to identify sequences that bound Lrp out of a pool of 10(12) different DNA molecules. We identified 63 related DNA sequences that bound Lrp and estimated their relative binding affinities for Lrp. A consensus sequence derived from analysis of these sequences, YAGHAWATTWT DCTR, where Y = C or T, H = not G, W = A or T, D = not C, and R = A or G, contains clear dyad symmetry and is very similar to the one defined earlier. To test the idea that Lrp in the presence of leucine might bind to a different subset of DNA sequences, we carried out a second selection experiment with leucine present during the binding reactions. DNA sequences selected in the presence or absence of leucine were similar, and leucine did not stimulate binding to any of the sequences that were selected in the presence of leucine. Therefore, it is unlikely that leucine changes the specificity of Lrp binding.
Bayesian Document Generative Model with Explicit Multiple Topics (2007)

In this paper, we proposed a novel probabilistic generative model to deal with explicit multiple-topic documents: Parametric Dirichlet Mixture Model(PDMM). PDMM is an expansion of an existing probabilistic generative model: Parametric Mixture Model(PMM) by hierarchical Bayes model. PMM models multiple-topic documents by mixing model parameters of each single topic with an equal mixture ratio. PDMM models multiple-topic documents by mixing model parameters of each single topic with mixture ratio following Dirichlet distribution. We evaluate PDMM and PMM by comparing F-measures using MEDLINE corpus. The evaluation showed that PDMM is more effective than PMM.
RF QUADRUPOLE BEAM DYNAMICS DESIGN STUDIES (1979)

The radio-frequency quadrupole (RFQ) linear accelerator structure is expected to permit considerable flexibility in achieving linac design objectives at low velocities. Calculational studies show that the RFQ can accept a high-current, low-velocity, dc beam, bunch it with high efficiency, and accelerate it to a velocity suitable for injection into a drift-tube linac. Although it is relatively easy to generate a satisfactory design for an RFQ linac for low beam currents, the space-charge effects produced by high currents dominate the design criteria. Methods have been developed to generate solutions that make suitable compromises between the effects of emittance growth, transmission efficiency, and overall structure length. Results are given for a test RFQ linac operating at 425 MHz.
Strength of different meniscus suturing techniques (1997)

We measured and compared the primary stabilities of five different meniscal suturing techniques. The techniques tested were horizontal mattress, vertical mattress, knot-end, vertical, and vertical loop. Twenty bovine medial menisci were cut to simulate peripheral longitudinal tears and repaired with one of the five suture techniques. Then the two parts of the meniscus were pulled using the Instron Tensometer until failure occurred. Knot-end techniques gave inferior results (mean ultimate failure strength 64 +/- 5 N) compared with the other techniques. Vertical mattress failed at 130 +/- 3 N, vertical loop at 128 +/- 4.5 N, horizontal mattress at 98 +/- 5 N and vertical suturing at 136 +/- 2.7 N. This study shows the superior mechanical characteristic of the vertical suturing technique.
The Short Life Span of <i>Saccharomyces cerevisiae sgs1</i> and <i>srs2</i> Mutants Is a Composite of Normal Aging Processes and Mitotic Arrest Due to Defective Recombination (2001)

Evidence from many organisms indicates that the conserved RecQ helicases function in the maintenance of genomic stability. Mutation of SGS1 and WRN, which encode RecQ homologues in budding yeast and humans, respectively, results in phenotypes characteristic of premature aging. Mutation of SRS2, another DNA helicase, causes synthetic slow growth in an sgs1 background. In this work, we demonstrate that srs2 mutants have a shortened life span similar to sgs1 mutants. Further dissection of the sgs1 and srs2 survival curves reveals two distinct phenomena. A majority of sgs1 and srs2 cells stops dividing stochastically as large-budded cells. This mitotic cell cycle arrest is age independent and requires the RAD9-dependent DNA damage checkpoint. Late-generation sgs1 and srs2 cells senesce due to apparent premature aging, most likely involving the accumulation of extrachromosomal rDNA circles. Double sgs1 srs2 mutants are viable but have a high stochastic rate of terminal G2/M arrest. This arrest can be suppressed by mutations in RAD51, RAD52, and RAD57, suggesting that the cell cycle defect in sgs1 srs2 mutants results from inappropriate homologous recombination. Finally, mutation of RAD1 or RAD50 exacerbates the growth defect of sgs1 srs2 cells, indicating that sgs1 srs2 mutants may utilize single-strand annealing as an alternative repair pathway.
LiCoO[sub 2] Electrode Particles Coated with Li[sub 2]S–P[sub 2]S[sub 5] Solid Electrolyte for All-Solid-State Batteries (2010)

Electrode/electrolyte composite materials for all-solid-state lithium secondary batteries were prepared by coating the (mol %) solid electrolyte onto electrode particles using the pulsed laser deposition method. Cross-sectional transmission electron microscopy images showed that the solid electrolyte layer was formed on the particles. The all-solid-state cell using the particles coated with the solid electrolyte was charged and discharged, and exhibited good cycle performance. This suggests that the electrolyte coatings provide a lithium-ion conduction path to , and the technique is effective in the development of all-solid-state cells.
Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis. American College of Gastroenterology, Practice Parameters Committee. (1997)

Guidelines for clinical practice are intended to suggest preferable approaches to particular medical problems as established by interpretation and collation of scientifically valid research, derived from extensive review of published literature. When data are not available that will withstand objective scrutiny, a recommendation may be made based on a consensus of experts. Guidelines are intended to apply to the clinical situation for all physicians without regard to specialty. Guidelines are intended to be flexible, not necessarily indicating the only acceptable approach, and should be distinguished from standards of care that are inflexible and rarely violated. Given the wide range of choices in any health care problem, the physician should select the course best suited to the individual patient and the clinical situation presented. These guidelines are developed under the auspices of the American College of Gastroenterology and its Practice Parameters Committee. These guidelines are also approved by the governing boards of American College of Gastroenterology and Practice Parameters Committee. Expert opinion is solicited from the outset for the document. Guidelines are reviewed in depth by the committee, with participation from experienced clinicians and others in related fields. The final recommendations are based on the data available at the time of the production of the document and may be updated with pertinent scientific developments at a later time. The following guidelines are intended for adults and not for pediatric patients.
<i>Clostridium difficile</i> toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex (2013)

Clostridium difficile infection (CDI) is a leading cause of health care-associated diarrhea and has increased in incidence and severity over the last decade. Pathogenesis is mediated by two toxins, TcdA and TcdB, which cause fluid secretion, inflammation, and necrosis of the colonic mucosa. TcdB is a potent cytotoxin capable of inducing enzyme-independent necrosis in both cells and tissue. In this study, we show that TcdB-induced cell death depends on assembly of the host epithelial cell NADPH oxidase (NOX) complex and the production of reactive oxygen species (ROS). Treating cells with siRNAs directed against key components of the NOX complex, chemical inhibitors of NOX function, or molecules that scavenge superoxide or ROS confers protection against toxin challenge. To test the hypothesis that chemical inhibition of TcdB-induced cytotoxicity can protect against TcdB-induced tissue damage, we treated colonic explants with diphenyleneiodonium (DPI), a flavoenzyme inhibitor, or N-acetylcysteine (NAC), an antioxidant. TcdB-induced ROS production in colonic tissue was inhibited with DPI, and both DPI and NAC conferred protection against TcdB-induced tissue damage. The efficacy of DPI and NAC provides proof of concept that chemical attenuation of ROS could serve as a viable strategy for protecting the colonic mucosa of patients with CDI.
Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A (2012)

Chromogranin A (ChgA) has been identified as the antigen target for three NOD-derived, diabetogenic CD4 T-cell clones, including the well-known BDC-2.5. These T-cell clones respond weakly to the peptide WE14, a naturally occurring proteolytic cleavage product from ChgA. We show here that WE14 can be converted into a highly antigenic T-cell epitope through treatment with the enzyme transglutaminase (TGase). The WE14 responses of three NOD-derived CD4 T-cell clones, each with different T-cell receptors (TCRs), and of T cells from BDC-2.5 TCR transgenic mice are increased after TGase conversion of the peptide. Primary CD4 T cells isolated from NOD mice also respond to high concentrations of WE14 and significantly lower concentrations of TGase-treated WE14. We hypothesize that posttranslational modification plays a critical role in the generation of T-cell epitopes in type 1 diabetes.
Electric Field Exposure from Electric Blankets (1987)

Comparisons of the 60 Hz electric field exposures associated with high voltage transmission lines to those associated with common household sources can provide an important input to regulatory decisions that involve transmission line fields. Electric blankets are of interest in this context because the exposures they produce are among the most intense and prolonged of any of the household sources of 60 Hz electric field exposure. This paper presents a theoretical analysis of the body surface fields induced by electric blankets. Electric blanket exposure intensities are compared to those associated with transmission lines.