gebhart/patrepeval huggingface dataset:
Resource bounded searches in an information marketplace (2000)

Over the past five years, we have been developing a Web-based, resource-bounded, information-gathering agent-called BIG, for Bounded Information Gathering-to support a human decision process. Although its techniques are general enough to apply to a wide range of domains, BIG specifically helps clients pick software packages. For example, a client can instruct BIG to recommend a database package for Windows 98 and specify constraints on both the search process and the product characteristics. BIG will then formulate a plan, locate and extract relevant information from both structured and unstructured documents, and return a recommendation to the client, along with supporting data. Our focus is on a recently developed capability, namely, to schedule information-gathering activity in a way that controls the money spent on acquiring information from sites that charge a fee for access. This capability supports an information marketplace on the Web, which we feel will eventually supersede (but obviously not completely replace) the current model of free information access supported by advertising fees.
Owner compliance with short term antimicrobial medication in dogs (1996)

The degree to which dog owners complied with instructions to administer a 5 to 10 day course of antimicrobial medication to their pets was assessed using microprocessor based monitoring devices. Twenty two clients gave an average of 84% of prescribed doses of amoxycillin-clavulanate. No difference was found between twice and thrice daily dosing regimens in the overall percentage of prescribed doses given. However, timing of doses was far from ideal in many cases and only 34% of doses were given within the designated optimum time period. Adherence to desired dosing intervals tended to be better with twice daily than with thrice daily dosing, although the difference was statistically insignificant.
Apoptosis in Maternal Peripheral Blood during Pregnancy (2000)

Apoptosis is stimulated in maternal peripheral blood during pregnancy, possibly accounting partly for the presence of free fetal DNA in maternal serum. The increased apoptosis rate in pregnancies with chromosomally abnormal fetuses may have additional clinical importance.
Integrated approach of multiple face detection for video surveillance (2003)

For applications such as video surveillance and human computer interfaces, we propose an efficiently integrated method to detect and track faces. Various visual cues are combined with the algorithm: motion, skin color, global appearance and facial pattern detection. The ICA (independent component analysis)-SVM (support vector machine) based pattern detection is performed on the candidate region extracted by motion, color and global appearance information. Simultaneous execution of detection and short-term tracking also increases the rate and accuracy of detection. Experimental results show that our detection rate is 91% with very few false alarms running at about 4 frames per second for 640 by 480 pixel images on a Pentium IV 1 GHz.
Hydration of the Carbonyl Group. A Theoretical Study of the Cooperative Mechanism (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydration of the Carbonyl Group. A Theoretical Study of the Cooperative MechanismSaul Wolfe, Chan-Kyung Kim, Kiyull Yang, Noham Weinberg, and Zheng ShiCite this: J. Am. Chem. Soc. 1995, 117, 15, 4240–4260Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/ja00120a005https://doi.org/10.1021/ja00120a005research-articleACS PublicationsRequest reuse permissionsArticle Views657Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
A Real Time Embedded Face Detector on FPGA (2006)

Intelligent computing systems demand human computer interfaces that detect and recognize the faces of human users at human interaction speeds. A real-time face detector accurately locates human faces in real-time video streams. While software implementations are effective with regards to accuracy and ease of integration, they suffer from low detection throughput on realtime video signals. In this paper we identify benefits and drawbacks of evolving face detection from software to hardware. We illustrate these tradeoffs by detailing the implementation of an artificial neural network face detector on a midsize FPGA. The prototype achieves 94% detection accuracy at real-time detection rates.
Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses. (1996)

A number of investigations have established the critical role of interleukin 4 (IL-4) in mediating the development of T helper (Th)2 effector cells in vitro and in vivo. Despite intensive study, the origin of the IL-4 required for Th2 priming and differentiation remains unclear. Natural killer (NK)1.1+ alpha/beta T cell receptor+ T(NT) cells, a unique lineage of cells capable of producing large amounts of IL-4 after activation in vivo, are important candidates for directing Th2 priming. These cells are selected by the nonpolymorphic major histocompatibility complex (MHC) class I molecule, CD1, and are deficient in beta 2-microglobulin (beta 2m)-null mice. We used beta 2m-deficient mice on both BALB/c and C57BL/6 backgrounds to examine their capacity to mount Th2 immune responses after challenge with a number of well-characterized antigens administered by a variety of routes. As assessed by immunization with protein antigen, infection with Leishmania major, embolization with eggs of Schistosoma mansoni, intestinal infection with Nippostrongylus brasiliensis, or induction of airway hyperreactivity to aerosolized antigen, beta 2m-deficient mice developed functional type 2 immune responses that were not substantially different than those in wild-type mice. Production of IL-4 and the generation of immunoglobulin E (IgE) and eosinophil responses were preserved as assessed by a variety of assays. Collectively, these results present a comprehensive analysis of type 2 immune responses in beta 2m-deficient mice, and indicate that beta 2m-dependent NT cells are not required for Th2 development in vivo.
Antiviral and Neuroprotective Role of Octaguanidinium Dendrimer-Conjugated Morpholino Oligomers in Japanese Encephalitis (2010)

Administration of Vivo-Morpholino effectively resulted in increased survival of animals and neuroprotection in a murine model of JE. Hence, these oligomers represent a potential antiviral agent that merits further evaluation.
Reduction of crystalline defects to 50/cm/sup 2/ in epitaxial layers over porous silicon for ELTRAN/sup R/ process (2002)

As the design rules of large scale integrated circuits (LSIs) progress, excellent gate oxide integrity (GOI) is demanded despite the requirement for thinner gate oxides. Crystal originated particles (COPs) are currently reported as killer defects for GOI on Czochralski-silicon (CZ-Si) wafers; however, an epitaxial layer on the CZ substrate gives quite good GOI characteristics because of the significantly small amount of COPs in it. It is expected that the epitaxial layer would be used in silicon-on-insulator (SOI), which is one of the candidates for high speed and low power consumption LSIs. We have already reported the epitaxial layer transfer (ELTRAN) method (Yonehara et al, 1994, and Sato et al, 1995), in which the epitaxial layer on porous Si was transferred on to a handle wafer to form an SOI wafer by bonding and etching back of porous Si with extremely high etching selectivity. In this paper, it is reported that the density of stacking faults, which is the major defect in these wafers, is significantly reduced to 50/cm/sup 2/ by controlling both the porous structure and the prebaking step before growth.
Proton conducting composite materials at intermediate temperatures (1995)

Composite materials offer one way to prepare an intermediate temperature superprotonic conductor. Composite materials based on proton conducting oxyacid salts can combine the optimised structure and conductivity of the salt with the mechanical strength, chemical stability etc. of the oxide material.
A comparative electromyographic analysis of the shoulder during pitching (1987)

Dynamic, fine-wire, intramuscular electromyography (EMG) was performed on 12 different shoulder muscles in 13 normal male subjects as they pitched a baseball. Seven were major league baseball pitchers and six were amateur pitchers. The act of pitching a fast ball was filmed at 450 frames per second with the EMG signals recorded synchronously. The subscapularis, supraspinatus, and infraspinatus muscles were tested in 13 subjects, the biceps brachii muscle was tested in 12, and other shoulder muscles were tested variously among the subjects. Two groups of muscles were identified. Group I muscles, the supraspinatus, infraspinatus, teres minor, deltoid, trapezius, and biceps brachii, served primarily to position the shoulder and elbow for the delivery of the pitch. These muscles were found to have greater activity during the early and late cooking stages, with less activity during acceleration. Group II muscles accelerated the arm and baseball forward in space. These muscles, the pectoralis major, serratus anterior, subscapularis, and latissimus dorsi, had stronger activity during the propulsive phase of the pitch. The professional pitchers were able to use the muscles about the shoulder in an efficient manner to achieve greater pitching velocities. The subscapularis and latissimus dorsi muscles of Group II had stronger activity among the professionals, whereas the supraspinatus, teres minor, and biceps brachii muscles of Group I had only minimal activity. The amateurs, on the other hand, continued to use all of the rotator cuff muscles and the biceps brachii muscle of Group I through the acceleration stage of the pitch.(ABSTRACT TRUNCATED AT 250 WORDS)
Effectiveness of Fluoroquinolones Against Mycobacterium abscessus In Vivo (2006)

Moxifloxacin, and to a lesser extent levofloxacin and ciprofloxacin, demonstrated significant effectiveness for reducing the number of M. abscessus in vivo, suggesting the potential usage of these agents in prevention of M. abscessus keratitis.
A Concise and Flexible Diastereoselective Approach to Heteroring-Fused Isoindolinones (2010)

A variety of poly and diversely substituted isoindoli­nones fused with six-membered heterocyclic moieties has been readily assembled through a sequence involving metalation of N-chloroalkylated models, subsequent interception with appropriate electrophiles and ultimate intramolecular annulation reaction.
Suffering from buffering? Detecting QoE impairments in live video streams (2017)

Fueled by increasing network bandwidth and decreasing costs, the popularity of over-the-top large-scale live video streaming has dramatically increased over the last few years. In this paper, we present a measurement study of adaptive bitrate video streaming for a large-scale live event. Using server-side logs from a commercial content delivery network, we study live video delivery for the annual Academy Awards event that was streamed by hundreds of thousands of viewers in the United States. We analyze the relationship between Quality-of-Experience (QoE) and user engagement. We first study the impact of buffering, average bitrate, and bitrate fluctuations on user engagement. To account for interdependencies among QoE metrics and other confounding factors, we use quasi-experiments to quantify the causal impact of different QoE metrics on user engagement. We further design and implement a Principal Component Analysis (PCA) based technique to detect live video QoE impairments in real-time. We then use Hampel filters to detect QoE impairments and report 92% accuracy with 20% improvement in true positive rate as compared to baselines. Our approach allows content providers to detect and mitigate QoE impairments on the fly instead of relying on post-hoc analysis.
Design And Performance Of Blocked-Impurity-Band Detector Focal Plane Arrays (1986)

Blocked-Impurity-Band (BIB) extrinsic silicon (Si:As) detectors have demonstrated high sensitivity and quantum efficiency in the long wavelength infrared (LWIR) spectral region (to 28 microns) as well as wide frequency response, low optical crosstalk, nuclear radiation hardness, and stable, predictable performance. Furthermore, it has been demonstrated that SWItched mosFET (SWIFET) multiplexers provide a low noise readout approach for use with BIB detectors. This paper describes the state-of-the-art of multiplexed BIB detector hybrid focal plane arrays (HFPAs). The principle of operation and performance of optimized BIB and Back Illuminated BIB (BIBIB) detectors are presented. The SWIFET multiplexer, including necessary circuitry for BIBIB detector readout, has been designed and fabricated using a newly developed process for cryogenic (<20K) MOS electronics which avoids anomalies (lack of device isolation, excess noise, and long time constants) associated with conventional silicon processes. A description of the design and operation of this multiplexer is given. A number of uniform, highly responsive, 500 element HFPAs have been fabricated and their performance evaluated. The characterization measurements, to be described in the paper, include evaluation of detector dark current, responsivity, noise for various operating conditions, and uniformity of array characteristics. The results obtained and presented demonstrate that focal plane arrays with excellent, unprecedented, LWIR performance have been realized with Blocked-Impurity-Band detector technology.
Calcium and The Control of Mammalian Cortical Granule Exocytosis (2001)

At fertilization, the release of intracellular calcium is necessary and sufficient for most, if not virtually all, of the major events of egg activation that are responsible for the onset of embryonic development. In mammalian eggs, repetitive calcium oscillations stimulate egg activation events through calcium-dependent effectors, such as calmodulin, protein kinases, and specific proteins involved in exocytosis. One of the earliest calcium-dependent events is the exocytosis of cortical granules (CGs), a secretory event resulting in the block to polyspermy and the prevention of triploidy. Emerging studies suggest that CG release in mature eggs is dependent upon calcium-dependent proteins similar to those in somatic cells employed to undergo calcium-regulated exocytosis. In contrast, pre-ovulatory oocytes are incompetent to undergo CG exocytosis due to deficiencies in the ability to release and respond to increases in intracellular calcium. The development of competence to release and respond to calcium is relevant to both animal and human in vitro fertilization programs that largely utilize ovarian oocytes not all of which are fully activation competent.
Development of Low NOx Combustion System with EGR for 1700°C-class Gas Turbine (2013)

*1 Takasago Research & Development Center, Technology & Innovation Headquarters *2 Deputy Manager, Gas Turbine Engineering Department, Power Systems *3 Chief Staff Manager, Takasago Research & Development Center, Technology & Innovation Headquarters *4 Deputy Director, Gas Turbine Engineering Department, Power Systems *5 Gas Turbine Engineering Department, Power Systems Development of Low NOx Combustion System with EGR for 1700°C-class Gas Turbine
In Vivo Regulation of Experimental Autoimmune Encephalomyelitis by NK Cells: Alteration of Primary Adaptive Responses (2008)

Innate immune responses provide the host with its first line of defense against infections. Signals generated by subsets of lymphocytes, including NK cells, NKT cells, and APC during this early host response determine the nature of downstream adaptive immune responses. In the present study, we have examined the role of innate NK cells in an autoimmune model through the use of primary immunization with the myelin oligodendrocyte glycoprotein peptide to induce experimental autoimmune encephalomyelitis (EAE). Our studies have shown that in vivo depletion of NK cells can affect the adaptive immune responses, because NK cells were found to regulate the degree of clinical paralysis and to alter immune adaptive responses to the myelin oligodendrocyte glycoprotein peptide. The requirement for NK cells was reflected by changes in the T cell responses and diminished clinical disease seen in mice treated with anti-NK1.1, anti-asialo GM1, and selected Ly49 subtype-depleted mice. In addition to alteration in T cell responses, the maturational status of dendritic cells in lymph nodes was altered both quantitatively and qualitatively. Finally, examination of TCR Vbeta usage of the brain lymphocytes from EAE mice indicated a spectra-type change in receptor expression in NK- depleted mice as compared with non-NK-depleted EAE mice. These findings further establish a recently postulated link between NK cells and the generation of autoreactive T cells.
A program form based on data dependency in predicate regions (1983)

A new program representation is presented which permits certain optimizations to be performed at less expense than with other forms. This paper describes code motion, common subexpression elimination and induction variable detection. Scalar propagation and constant folding are sketched here, but detailed elsewhere. The powerful code motion strategy allows entire regions of the program to be moved. The representation described may be used as a compiler intermediate form or simply as a model for program analysis. It has great potential for use in translation for parallel machines.
Ca2+-stimulated, Mg2+-dependent ATPase activity in neutrophil plasma membrane vesicles. Coupling to Ca2+ transport. (1984)

Low concentrations of free Ca2+ stimulated the hydrolysis of ATP by plasma membrane vesicles purified from guinea pig neutrophils and incubated in 100 mM HEPES/triethanolamine, pH 7.25. In the absence of exogenous magnesium, apparent values obtained were 320 nM (EC50 for free Ca2+), 17.7 nmol of Pi/mg X min (Vmax), and 26 microM (Km for total ATP). Studies using trans- 1,2-diaminocyclohexane- N,N,N',N',-tetraacetic acid as a chelator showed this activity was dependent on 13 microM magnesium, endogenous to the medium plus membranes. Without added Mg2+, Ca2+ stimulated the hydrolysis of several other nucleotides: ATP congruent to GTP congruent to CTP congruent to ITP greater than UTP, but Ca2+-stimulated ATPase was not coupled to uptake of Ca2+, even in the presence of 5 mM oxalate. When 1 mM MgCl2 was added, the vesicles demonstrated oxalate and ATP-dependent calcium uptake at approximately 8 nmol of Ca2+/mg X min (based on total membrane protein). Ca2+ uptake increased to a maximum of approximately 17-20 nmol of Ca2+/mg X min when KCl replaced HEPES/triethanolamine in the buffer. In the presence of both KCl and MgCl2, Ca2+ stimulated the hydrolysis of ATP selectively over other nucleotides. Apparent values obtained for the Ca2+-stimulated ATPase were 440 nM (EC50 for free Ca2+), 17.5 nmol Pi/mg X min (Vmax) and 100 microM (Km for total ATP). Similar values were found for Ca2+ uptake which was coupled efficiently to Ca2+-stimulated ATPase with a molar ratio of 2.1 +/- 0.1. Exogenous calmodulin had no effect on the Vmax or EC50 for free Ca2+ of the Ca2+-stimulated ATPase, either in the presence or absence of added Mg2+, with or without an ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N',-tetraacetic acid pretreatment of the vesicles. The data demonstrate that calcium stimulates ATP hydrolysis by neutrophil plasma membranes that is coupled optimally to transport of Ca2+ in the presence of concentrations of K+ and Mg2+ that appear to mimic intracellular levels.
Antigen-specific immune responsiveness and lymphocyte recruitment in leukocyte adhesion deficiency type II (1997)

The leukocyte adhesion deficiency syndrome type II (LAD-II) is caused by a general defect in fucose metabolism, which leads to the absence of fucosylated sugar determinants such as the selectin ligand SLe(x). In view of the important role of selectins in lymphocyte migration and homing, we have explored the in vivo immune responsiveness and lymphocyte recruitment to the skin, in response to the neo-antigen keyhole limpet hemocyanin (KLH) in a LAD-II patient. We observed a normal priming of KLH-specific T cells as well as a strong in vivo anti-KLH antibody response, both indicative of a normal T-B cell function and collaboration. Skin biopsies from the patient's skin taken prior to antigenic challenge showed the presence of normal numbers and subsets of T cells. Upon KLH injection, a large number of T cells were found to be recruited to the site of challenge, which was paralleled by up-regulation of the endothelial adhesion molecules ICAM-1 (CD54), VCAM-1 (CD106) and E-selectin (CD62E). The recruited T cell showed a normal subset distribution but lacked cutaneous lymphocyte antigen (CLA), the cutaneous homing receptor. However, the clinical symptoms of delayed-type hypersensitivity in the patient (redness and swelling) were severely depressed compared to that in the controls. In conclusion, the LAD-II patient showed a normal T cell priming and T cell-dependent antibody response, a normal baseline skin homing, and a significant T cell recruitment to the site of KLH challenge, indicating that fucosylated sugar determinants such as SLe(x) and CLA are not strictly required for adequate immune responsiveness and (skin) homing.
The B-Alkyl Suzuki-Miyaura Cross-Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis (2001)

The development of new reactions that facilitate the creative and efficient synthesis of molecular structures with desirable properties continues to fascinate chemists. The test of a significant contribution is its acceptance over time by the scientific community. The B-alkyl Suzuki-Miyaura cross-coupling reaction appears to be one such reaction. Since its disclosure by Suzuki and Miyaura in 1986, this reaction has been an attractive solution to challenging synthetic problems.