gebhart/patrepeval huggingface dataset:
Preparation of an Autolysis-Resistant Interleukin-1β Converting Enzyme Mutant (1996)

We describe the expression, purification, and characterization of human interleukin-1 beta converting enzyme (ICE) containing an affinity tag and modified to resist autoproteolysis. The point mutation Asp381 to Glu was added to eliminate the major site of autolytic degradation while maintaining catalytic activity, and an N-terminal polyhistidine tag was added in place of the ICE pro-region to facilitate purification. N-His (D381E) ICE was expressed in Escherichia coli and purified by nickel-chelating Sepharose and size-exclusion chromatography (SEC). The enzyme was stabilized greater than 80-fold against autolytic degradation relative to wild-type N-His ICE. SDS-PAGE analysis with silver-staining revealed no impurities, and 85% of the protein was catalytically active as determined by titration with a novel titrant, PD 163594 (3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino)prop ionylamino]-4- oxo-5-(2-oxo-2H-chromen-7-yloxypentanoic acid). An oxidized adduct of ICE with glutathione, formed by disulfide rearrangement with oxidized glutathione to inhibit and stabilize the enzyme during purification, was rapidly reduced upon exposure to 5 mM DTT. One mole of glutathione was released per mole of active enzyme. Of the nine cysteines in ICE, eight were present in their reduced form in the glutathione adduct. N-His (D381E) ICE cleaved Ac-YVAD-Amc with the Michaelis-Menten parameters K(M) = 14 microM and Kcat = 0.7 s-1, values essentially identical to those reported for enzyme from natural sources.
The Vesta Software Configuration Management System (2002)

Vesta is a system for software configuration management. It stores collections of source files, keeps track of which versions of which files go together, and automates the process of building a complete software artifact from its component pieces. Unlike other software configuration management systems, Vesta was specifically designed to handle very large projects—tens of millions of lines of code and beyond. Vesta’s novel approach gives it three important properties not available in other systems. First, every build is repeatable, because its component sources and build tools are stored immutably and immortally, and its configuration description completely describes what components and tools are used and how they are put together. Second, every build is incremental, because results of previous builds are cached and reused. Third, every build is consistent, because all build dependencies are automatically captured, recorded, and checked, so that a cached result from a previous build is reused only when doing so is certain to be correct. In addition, Vesta’s flexible language for writing configuration descriptions makes it easy to describe large software configurations in a modular fashion and to create variant configurations by customizing build parameters. This report describes the Vesta technology in detail and discusses the performance of our implementation.
SoC synthesis with automatic hardware-software interface generation (2003)

Design of efficient system-on-chips (SoCs) requires thorough application analysis to identify various compute intensive parts. These compute intensive parts can be mapped to hardware in order to meet the cost as well as the performance constraints. However, faster time to market requires automation of synthesis of these code segments of the application from high level specification such as C along with its interfaces. Such a synthesis system should be able to generate hardware which is easily pluggable in various types of architectures, as well as augment the application code to automatically take advantage of this new hardware component. In this paper, we address this problem and present an approach for complete SoC synthesis. We automatically generate synthesizable VHDL for the compute intensive part of the application along with necessary interfaces. Our approach is generic in the sense that it supports various processors and buses by keeping a generic hardware interface on one end and a dedicated one on the other. The generated hardware can be used in a tightly or loosely coupled manner in terms of memory and register communication. We present the effectiveness of this approach for some commonly used image processing spatial filter applications.
Simultaneous pose and reliability estimation using convolutional neural network and Rao–Blackwellized particle filter (2018)

In this study, we propose a novel localization approach that simultaneously estimates the reliability of estimation results. In the approach, a convolutional neural network (CNN) is used to make decision whether the localization process has failed or not. We train the CNN using a dataset that includes successful localization results and faults. However, the decision will contain some noise and many misdetection results may occur when the decision made by the CNN is used directly to detect faults. Therefore, we estimate both a robot's pose and reliability of the localization results based on the decision. To simultaneously estimate the robot's pose and reliability, we propose a new graphical model and implement a Rao–Blackwellized particle filter based on the model. We evaluated the proposed approach based on simulations and actual environments, which showed that the reliability estimated by the proposed approach can be used as an exact criterion for detecting localization faults. In addition, we show that the proposed approach can be applied in actual environments even when a dataset created from a simulation is used to train the CNN.
Relationship of Growth Hormone, Prolactin and Thyrotropin Secretion to Individual and Progeny Performance of Hereford Bulls3 (1987)

Six Hereford bulls from a line selected with an index of body weight and muscling score were compared with six bulls from a control line to determine if increased growth in the selected line was associated with changes in plasma levels of growth hormone (GH), prolactin (PRL) and (or) thyrotropin (TSH). The predictive value of sire hormone data for growth rate of progeny was also evaluated. Bulls of the index line were heavier at birth (P less than .02) and had higher postweaning daily gains (P less than .01) than bulls of the control line. Blood samples were collected from bulls (ages 2 and 3 yr) at 15-min intervals for 8 h. Overall plasma GH concentrations were higher (P less than .03) in the index bulls than those in the control line. All characteristics of PRL secretion examined tended to be higher in the index bulls, but only mean overall and baseline differences approached significance (P less than .10). There were no significant differences in measures of TSH secretion between lines. Sire differences in hormone characteristics accounted for significant amounts of variation in birth weight and postweaning gain of progeny, but not in gain to weaning. Also, when considered jointly, hormone characteristics generally added significantly to predictions that used sire growth rate alone. The results suggest that serum hormone characteristics in parents may provide additional predictors of growth rates of progeny.
On the morphology of cadmium sulphide epitaxial layers on germanium, observation of six‐pointed star optic figures and their explanation (1977)

Abstract The morphology was investigated of the cadmium sulphide epitaxial layers, grown on germanium substrate with orientation (111), in a quasi‐closed “sandwich” system in hydrogen atmosphere. Regular hexagonal compound pyramids were observed, tipped and truncated, with a plane slope abruptly changed. With the orientation of the layer (000) CdS ∥ (111) Ge , the orientations of the pyramid planes were determined to be of the type (01 1 3), (01 1 4) and (01 1 5). Regular six‐pointed optic stars were observed in those pyramids. Explanation of the stars observed is presented. A method is proposed for the determination of the cadmium sulphide layer thickness, using the data from the pyramids and the optic stars. The same stars were obtained with the elaborated models as well.
p-Toluenesulphonyl Derivatives of N,N'-bis-(4-quinolino-4-quinaldino/4-quinazolino and 9-acridino) Polymethylene Diamines as Hypoglycemic Agents (1975)

Organic Division, Chemistry Department, Banaras Hindu University, Varanasi-5 <em>Manuscript received 1 November </em>1971; <em>accepted </em>29 <em>April </em>1975 In view of the encouraging results shown by a number of bis-benzimidazole-2-sulphonamido derivatives as hypoglycemic agents (under communication), a series of compounds namely p-­toluenesulphonyl derivatives of N,N<sup>'</sup>-bis-(4-quinolino/4-quinaldino/4-quinazolino and 9-acridino) polymethylene diamines have been prepared and screened for their hypoglycemic activity. Some of the compounds showed significant blood sugar lowering activity in rats.
Oxygen distribution in microcirculation after arginine vasopressin-induced arteriolar vasoconstriction (2004)

The microvascular distribution of oxygen was studied in the arterioles and venules of the awake hamster window chamber preparation to determine the contribution of vascular smooth muscle contraction to oxygen consumption of the microvascular wall during arginine vasopressin (AVP)-induced vasoconstriction. AVP was infused intravenously at the clinical dosage (0.0001 IU.kg(-1).min(-1)) and caused a significant arteriolar constriction, decreased microvascular flow and functional capillary density, and a substantial rise in arteriolar vessel wall transmural Po(2) difference. AVP caused tissue Po(2) to be significantly lowered from 25.4 +/- 7.4 to 7.2 +/- 5.8 mmHg; however, total oxygen extraction by the microcirculation increased by 25%. The increased extraction, lowered tissue Po(2), and increased wall oxygen concentration gradient are compatible with the hypothesis that vasoconstriction significantly increases vessel wall oxygen consumption, which in this model appears to constitute an important oxygen-consuming compartment. This conclusion was supported by the finding that the small percentage of the vessels that dilated in these experiments had a vessel wall oxygen gradient that was smaller than control and which was not determined by changes in tissue Po(2). These findings show that AVP administration, which reduces oxygen supply by vasoconstriction, may further impair tissue oxygenation by the additional oxygen consumption of the microcirculation.
Influence of Grain Size on Thermal Conductivity of SiC Ceramics (2011)

SiC fiber reinforced-SiC ceramic matrix (SiCf/SiC) composites are one of the candidate structural materials for nuclear fusion reactors systems because of their low activation, mechanical property and chemical stability at high temperature. High thermal conductivity of SiCf/SiC composites is required to reduce heat load and to provide high thermal conversion efficiency. The objective of this study is to determine thermal conductivity on grain size dependence of SiC ceramics which is the matrix in composites. β-SiC powder was sintered by hot-press method. Al2O3 and Y2O3 were used as sintering additives. The grains size was grew with increase of holding time at 1900 °C. Thermal conductivity of SiC ceramics was gradually increased up to 112 W/mK. Thermal conductivity of SiC ceramics is dependent on growth of grain size due to the scattering of the phonon by the grain boundaries leads to a size-dependence.
Swallowing accelerometry signal feature variations with sensor displacement (2015)

Dual-axis accelerometry has recently shown promise as a non-invasive method for detecting swallowing impairment using signal processing and pattern classification algorithms. However, it is unknown whether variations in sensor placement alter signal characteristics, threatening the accuracy of signal processing classifiers for aspiration detection. To address this question, water swallows were recorded in 14 healthy adults using a dual-axis accelerometer in 13 different positions (baseline, and 2, 4, 6 and 8 mm above, below and to the right of baseline). The baseline position was midline, immediately below the thyroid cartilage during quiet breathing. After segmentation and pre-processing, signal features were extracted in multiple domains (time, frequency, time-frequency). The effect of sensor position on signal feature distributions was examined with non-parametric statistical analysis. The analysis showed that the sensor could be displaced by as much as 4 mm inferior and lateral to the baseline position and by up to 6 mm above the baseline location without significantly altering time-frequency features. In other words, when considering the baseline position as the origin, the admissible region for sensor placement spans 10 mm in the superior-inferior axis and 8 mm in the medial-lateral direction. Results of this study suggest that time-frequency representations of accelerometry signals are most robust to sensor placement variations around the baseline position. The implication of this finding is that a swallowing accelerometry classifier based on time-frequency features can likely tolerate small variations in sensor location without degradation in classification performance.
Engineering Design Data for Aluminum Alloy 7050-T73651 Plate (1973)

Abstract : Mechanical properties of aluminum alloy 7050-T73651 one-inch thick plate were determined and then compared to other high strength aluminum alloys. The fracture, fatigue crack growth, and stress corrosion properties and the flaw sensitivity index for the 7050-T73651 alloy were equal to or better than similar properties for other 7000 series aluminum alloys at similar strength levels. Conventional notched and smooth fatigue data indicated that the 7050- T73651 alloy had fatigue properties somewhat below those of 7049-T73, but equal to most other aluminum alloys. Environmental fatigue crack growth tests indicated that the crack growth rate was significantly accelerated by the presence of a 3.5 per cent sodium chloride solution environment. Changes in the specimen width were found to have an effect on the conditional fracture toughness values. (Author)
Carbon dioxide sequestration through silicate degradation and carbon mineralisation: promises and uncertainties (2018)

Abstract Turning carbon dioxide (CO 2 ) into rocks: controlling this process, which naturally operates at the Earth’s surface over geological timescales, is likely to represent a major technological challenge of this century. One of the recurring criticisms with the carbonation reactions is their sluggishness, as it is commonly admitted that converting silicates into carbonates within geologic reservoirs may take up to several thousands of years, i.e., a duration which is hardly compatible with the goal of achieving net zero emissions by mid-century. Last year, a study that generated substantial interest suggested that after 2 years, more than 95% of the CO 2 injected over the course of a pilot project of CO 2 injection in lava flows in Iceland might have been mineralised into carbonates. While such results could have been considered as a green light for industrial applications, a new high-profile study based on the same pilot experiment tempered this idea, as it revealed unexpected modifications of deep ecosystems in response to CO 2 injection, evidencing a bloom of chemolithoautotrophic bacteria, which have the ability to promote autotrophic C-fixation. Stated in other words, part of the CO 2 that was initially thought to be mineralised under the form of stable carbonates might instead have been converted into (much more labile) biomass. Assessing the respective contributions of carbonates and biomass to the C-sequestration should therefore represent a prerequisite prior to large-scale carbon capture and storage through mineral carbonation, to make sure that the cure is not worse than the disease.
A methachromatic-based experimental model for identification of bowel as the focus of an acute inflammation (2013)

Diarrhea is the most common symptom of acute inflammation in gastrointestinal tract and the patients are isolated in order to inhibit transmission and to conduct investigations. Yet there is no standard test to distinguish gastrointestinal infection from more generalized diseases at admittance which might cause delay in therapy. Hepatocyte growth factor (HGF) is produced upon injury by mesenchymal cells. On the contrary to chronic inflammation, HGF produced in the course of acute inflammation is biologically active and shows binding affinity to heparan sulphate proteoglycan (HSPG) and dextran sulphate (DS). Based on this phenomenon, an agarose gel containing DS was prepared and immobilized on loops to investigate the feces samples for the presence or absence of growth factors such as HGF with affinity to DS. The study is conducted as a clinical evaluation of an experimental model to distinguish acute infectious gastroenteritis from other causes of diarrhea. 656 fecal samples gathered consequently from patients seeking for bowel disturbances and healthy were tested by the test and the medical reports were investigated. Upon interaction with DS, methylene blue changes color to pink. This phenomenon was inhibited by HGF and converted by addition of anti-HGF antibodies to the samples. The test distinguished acute infectious gastroenteritis with high sensitivity and specificity (96% and 92% respectively) from other causes of diarrhea. We introduce a metachromatic experimental model that might distinguish acute inflammation in alimentary tract from other causes of diarrhea. This model might be used in developing rapid diagnostic tests.
High sensitivity dry film photoresist for laser direct imaging system (2003)

We here introduce the dry film photo resist (DFR) used in the UV laser direct image (LDI) photo exposure system. The LDI system has the following advantages: special resist film is not required. The circuit pattern design can be changed easily. It is possible to reduce the manufacturing cost due to mechanization of the exposure process. The quality and the yield obtained by this mechanization can be improved. However, because the laser moves at high speed when DFR is exposed, the amount of the exposure to polymerize must be less than that of the usual method. Therefore, the DFR must have high photosensitivity and this we have developed. This new DFR can be used in the usual process of manufacturing print circuit boards (PCB) as well as other products using DFR in their manufacture. This DFR has been put on the market as UL500. We also introduce the current situation of the printing industry, which is working on the introduction of the LDI system.
Inhibition of Cutaneous Anaphylaxis and Arthus Reactions in the Mouse by Antigen-Specific IgA (1981)

The nitrophenyl-specific IgA myeloma protein secreted by the MOPC-315 mouse plasmacytoma was examined for its capacity to inhibit antibody-mediated hypersensitivity reactions in the mouse. Specific inhibition of both cutaneous anaphylactic and complement-dependent (Arthus) reactions was observed in sensitised mice when the eliciting antigen was mixed with IgA prior to injection or when the mice injected with plasmacytoma cells and possessed detectable amounts of MOPC-315 IgA in their serum at the time of challenge. The possibility that IgA antibodies have a role in suppressing hypersensitivity reactions at mucosal surfaces is discussed.
Passenger flow control with multi-station coordination in subway networks: algorithm development and real-world case study (2018)

This paper addresses the problem of passenger flow control in a multi-line subway network during peak hours. A new multi-station coordinated passenger flow control model is proposed to simultaneously adjust the number of inbound and transfer passengers entering multiple stations or lines. The implementation of passenger flow control governs the redundant passengers to queue at given facilities, which is similar to ramp metering that regulates the number of vehicles entering a highway segment. The proposed model is a bi-level programming, whose upper level aims to optimize the system performance with different passenger flow control strategies, while the lower level is a logit-based stochastic user equilibrium assignment problem under a given strategy, considering passenger flow evolution, dynamic path cost, and route choice. An algorithm, integrating the method of successive averages with genetic algorithm, is developed to solve the model. A real-world case study is conducted to examine the validity.
Reconstruction of fiber grating period profiles by use of Wigner–Ville distributions and spectrograms (2000)

The grating-period profile and length of an arbitrary fiber Bragg grating structure can be reconstructed from the structure’s reflection response by use of a time–frequency signal representation based on the well-known Wigner–Ville distribution and spectrogram. We present a detailed description of this synthesis technique. By means of numerical simulations, the technique is tested with several fiber grating structures. In general, our results show good agreement between exact and reconstructed functions. The technique’s advantages and limitations are discussed. We propose and demonstrate the application of the proposed synthesis technique to distributed mechanical strain or temperature sensing.
Assessing the value of a cancer clinical nurse specialist (2007)

NHS organisations are going through challenging financial times, in line with government-directed financial and structural reforms. It is acknowledged that cost cutting measures help balance the books in the short term, but there is a danger here that the role of the cancer clinical nurse specialist (CNS) could be seen as a luxury. Any plans to reduce numbers of specialist cancer nurses would, many believe, undermine the key government policy objectives of delivering the NHS Modernisation Agenda. This paper describes how the cancer CNS can help deliver quality clinical care within tight financial limits. It is based on a focus group held with Macmillan Cancer Support CNSs discussing their impact on the delivery of the Modernisation Agency’s 10 High Impact Changes.
A new foam for support of the physically handicapped. (1975)

This article is intended to inform professionals in the fields of rehabilitation medicine and biomedical engineering of some of the more significant properities of Temper Foam, a new foam for support of the physically handicapped. The unique properties of this foam are explained in terms of its microstructure, illustrated by scanning electron micrographs and by mechanical tests using an Instron Materials Testing machine. Fourteen non-ambulatory patients with Duchenne muscular dystrophy are using this foam in custom-fitted contoured support systems. Normally, these children show increasing signs of discomfort and skin breakdown due to their inability to alternate areas of weight bearing and high local pressure such as the ischial tuberosities. In our support systems lined with Temper Foam these problems have completely dissappeared. We find that Temper Foam types T-36, T-38 and -41 are ideally suited for patients weighing up to 35 kg. T-41 may be used for patients weighing up to 70 kg.
High-speed AFM of human chromosomes in liquid (2008)

Further developments of the previously reported high-speed contact-mode AFM are described. The technique is applied to the imaging of human chromosomes at video rate both in air and in water. These are the largest structures to have been imaged with high-speed AFM and the first imaging in liquid to be reported. A possible mechanism that allows such high-speed contact-mode imaging without significant damage to the sample is discussed in the context of the velocity dependence of the measured lateral force on the AFM tip.
The Theory of Hedging and Speculation in Commodity Futures (1960)

The Theory of Hedging and Speculation in Commodity Futures Get access Leland L. Johnson Leland L. Johnson Search for other works by this author on: Oxford Academic Google Scholar The Review of Economic Studies, Volume 27, Issue 3, June 1960, Pages 139–151, https://doi.org/10.2307/2296076 Published: 01 June 1960