gebhart/patrepeval huggingface dataset:
Ribosome and transcript copy numbers, polysome occupancy and enzyme dynamics in <i>Arabidopsis</i> (2009)

Plants are exposed to continual changes in the environment. The daily alternation between light and darkness results in massive recurring changes in the carbon budget, and leads to widespread changes in transcript levels. These diurnal changes are superimposed on slower changes in the environment. Quantitative molecular information about the numbers of ribosomes, of transcripts for 35 enzymes in central metabolism and their loading into polysomes is used to estimate translation rates in Arabidopsis rosettes, and explore the consequences for important sub-processes in plant growth. Translation rates for individual enzyme are compared with their abundance in the rosette to predict which enzymes are subject to rapid turnover every day, and which are synthesized at rates that would allow only slow adjustments to sustained changes of the environment, or resemble those needed to support the observed rate of growth. Global translation rates are used to estimate the energy costs of protein synthesis and relate them to the plant carbon budget, in particular the rates of starch degradation and respiration at night.
Antifungal Studies on Drugs. I. : Antifungal Activity of Five-membered Lactone Derivatives (1968)

Antifungal activity of seventy-one compounds having five-membered lactone were tested. Among them six (No. 10, 17, 32, 44, 65, and 67) showed a minimum growth inhibitory activities in 0.125-0.5 mg/ml against fungi. The relationships between structure and antifungal activity were also discussed.
Intrathecal administration of AYX2 DNA decoy produces a long-term pain treatment in rat models of chronic pain by inhibiting the KLF6, KLF9, and KLF15 transcription factors (2017)

These data highlight KLF6, KLF9, and KLF15 as transcription factors required for the maintenance of chronic pain and illustrate the potential therapeutic benefits of AYX2 for the treatment of chronic pain.
ASTRA creatinine reagent stability. (1984)

Journal Article ASTRA creatinine reagent stability. Get access A Posner A Posner Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 30, Issue 6, 1 June 1984, Page 1105, https://doi.org/10.1093/clinchem/30.6.1105 Published: 01 June 1984
Partial Purification and Characterization of Messenger RNA Coding 14‐3‐2 Protein from Rat Brain (1982)

14-3-2 Protein (neuron-specific enolase) is a neuron-specific protein. Using a reticulocyte lysate cell-free system for translation of 14-3-2 protein mRNA, we have partially purified this mRNA by several procedures, including formamide sucrose density centrifugation, formamide polyacrylamide gel electrophoresis (PAGE) and polyuridylic acid (poly(U))-Sepharose affinity chromatography. Using mRNA obtained by these procedures, we could increase the translation ratio of 14-3-2 protein synthesized/total soluble protein synthesized to 7.31%. The overall purification was 37.8-fold. The size of 14-3-2 protein mRNA appears to be about 19-20S, because translation activity of mRNA obtained by sucrose density gradient centrifugation or formamide PAGE was the most active in this RNA size.
The Effect of Shell Egg Pasteurization on the Protein Quality of Albumen (2001)

The effect of a low-temperature, extended-time, in-shell pasteurization process on the protein quality of egg albumen was evaluated. Ten dozen fresh chicken eggs were pasteurized in a hot-air oven at 55 C for 180 min. The eggs were refrigerated and broken out for analysis on Days 0, 7, 14, 28, 42, and 56 following pasteurization. There were no significant differences in total or soluble protein over the experimental period for the pasteurized or unpasteurized albumen. Mean protein content was 80.6 +/- 0.5% for the pasteurized albumen and 80.9 +/- 0.5% for the unpasteurized albumen. In vitro digestibility, as measured by the AOAC method, was 82.4 +/- 0.7% for the pasteurized albumen and 81.7 +/- 0.6% for the unpasteurized albumen. There were no significant differences over the experimental period in the digestibility of the samples. Free amino acids and discriminant-computed protein efficiency ratio (DC-PER) also did not differ between the pasteurized and unpasteurized albumens or over the experimental period. The in-shell pasteurization process used had no effect on the protein quality of albumen.
Defluorination of Monofluoroacetate by Bacteria (1965)

(1) Bacteria capable of assimilating FA as a source of carbon have been isolated from soil obtained at the factory producing FA. The assimilation of FA was fairly stable and very strong in this organism. It appeared to belong to a member of Pseudomonas species. (2) The enzyme that catalyzes defluorina-tion of FA to form glycolic acid and fluoride ions was induced, when bacteria were grown in a defined salt medium containing FA as a sole source of carbon. Glycolic acid was identified as a salt of S-benzylthiuronium after being isolated by a chromatography in silica colum. (3) The liberation of fluoride ions from monofluoroacetamide and monofluoropropiona-te was very small compared with the libera-tion from FA. Monochloro-, monobromo-, and monoiodoacetate were not dehalogenated by the enzyme.
SOLVENT EXTRACTION OF ANTHOCYANINS FROM WINE POMACE (1980)

ABSTRACT There is considerable interest in utilization of natural pigment as food colorants, particularly from raw materials in adequate supply, such as wine grape pomace. The rate and degree of extraction of anthocyanins from grape pomace depends upon a number of factors; this research concerned two: solvent (ethanol, methanol, water), and acid (HCl, citric, tartaric, formic, acetic, propionic). Methanol was the best extractant being 20% more effective than ethanol and 73% more effective than water. HCl was most effective with ethanol, but is also very corrosive. Of the organic acids, citric was most effective with methanol and acetic acid with water.
Safety of budesonide in saline sinonasal irrigations in the management of chronic rhinosinusitis with polyposis: lack of significant adrenal suppression. (2008)

Budesonide in saline sinonasal irrigation for the treatment of refractory CRSwP does not cause HPA axis suppression. The efficacy of this higher dose of steroid delivered locally would benefit from further study.
Abstract C127: Chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC activities (2015)

Abstract Background: Podoplanin (PDPN), a platelet aggregation-inducing transmembrane glycoprotein, is expressed in a variety of tumors, and binds to C-type lectin-like receptor-2 (CLEC-2). Overexpression of PDPN is involved in invasion and metastasis. Several anti-PDPN monoclonal antibodies (mAbs) such as NZ-1 showed antimetastatic activities by binding to platelet aggregation-stimulating (PLAG) domain of PDPN. Recently, we developed a novel mouse anti-PDPN mAb, LpMab-7 using the cancer-specific mAb (CasMab) method. LpMab-7 is more sensitive than anti-PLAG domain mAbs. Methods: We generated and characterized a mouse-human chimeric anti-PDPN mAb, chLpMab-7. We investigated antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activities in vitro. Furthermore, we evaluated the in vivo efficacy of chLpMab-7 using both xenograft models and experimental metastasis models. In xenograft models, PDPN-expressing CHO (CHO/hPDPN) or a lung cancer cell line PC-10 was engrafted into nude mice. In experimental metastasis models, CHO/hPDPN cells were inoculated into tail vein of the nude mice. Results: ChLpMab-7 antibody showed ADCC and CDC activities against CHO/hPDPN, glioblastoma, mesothelioma, or lung cancer cell lines. Treatment with chLpMab-7 abolished both tumor growth in xenograft and spontaneous pulmonary metastasis. ChLpMab-7 exhibited dramatic suppression of experimental pulmonary metastasis, even when it was injected five days after the inoculation of tumor cells. Conclusion: ChLpMab-7 suppressed tumor development and hematogenous metastasis via ADCC/CDC activities. PDPN should be useful as a novel antibody-based therapy. Citation Format: Yukinari Kato, Mika K. Kaneko. Chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC activities. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr C127.
Environmental characterization with magnetics and STOLS (1994)

The application of techniques utilizing total field magnetic anomaly measurements can contribute significantly to the environmental characterization of lands contaminated with hazardous, toxic, or radioactive wastes. By addressing the correlated problem of detection and characterization of HTRW waste containers, predominantly made of ferromagnetic materials, high-density magnetics systems can be used to characterize a wide range of buried hazardous materials. Ferromagnetic materials such as iron and steel, induce an observable secondary magnetic field which can be measured and modeled to yield estimates of location, depth, and mass of the ferromagnetic objects. As a passive geophysical technique magnetics is logistically tractable, allowing for development of systems which acquire high density data over large areas. The STOL magnetics detection system was developed for this purpose, and is outfitted with seven total field magnetometers which are integrated with a differential GPS to provide 20 Hz magnetic-field measurements positioned with nominal absolute position accuracy of 30 cm. Processing of magnetic data requires the removal of the Earth's primary field and the interpolation onto a mesh. Image processing techniques are applied to enhance and segment the data for anomaly delineation. Isolated anomalies are modeled under the point dipole assumption to produce estimates of object position, depth, and mass.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Preparation and characterization of PBNN multilayer piezoelectric actuator (2002)

The preparation and characterization of multilayer actuators with fifty layers (100 /spl mu/m in thickness) of piezoelectric [(Pb/sub (1-x/)Ba/sub x/)/sub 6-y/(NaLi)/sub y/Nb/sub 10/O/sub 30/] (PBNN) were reported, which were prepared by tape-casting and cofired with internal Pd30+Ag70 electrodes. The PBNN wafers prepared by the tape-casting technique were compared with those prepared by conventional dry-pressure techniques. Delaminations occurring in the layers of some actuators were observed and discussed. The obtained high linearity and low hysteresis in the displacement-applied field, the symmetric displacement under positive and negative applied field, were discussed in relation to the crystal and domain structure.
Kinetics of electron-transfer reactions between transition-metal complexes and the methyl viologen radical cation (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of electron-transfer reactions between transition-metal complexes and the methyl viologen radical cationKevin R. Howes, C. Greg Pippin, James C. Sullivan, Dan Meisel, James H. Espenson, and Andreja BakacCite this: Inorg. Chem. 1988, 27, 17, 2932–2934Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/ic00290a008https://doi.org/10.1021/ic00290a008research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Serial Algorithm for high-speed autofocusing of cells using Depth From Diffraction (DFDi) method (2008)

In this paper, a new serial algorithm for highspeed autofocusing of cells is proposed. The proposed algorithm extracts depth information of target cells from their diffraction patterns. High-speed focusing of yeast cells with 20 ms response time was demonstrated. Continuous autofocusing of yeast cells with a scanning microscope was also demonstrated. The successful continuous autofocusing suggests that image-based high- throughput measurement of cells could be realized using the proposed algorithm.
Image and video processing using MAJC 5200 (2002)

The newly introduced Microprocessor Architecture for Java Computing (MAJC) supports parallelism in a hierarchy of levels: multiprocessors on chip, vertical micro threading, instruction level parallelism via a very long instruction word architecture (VLIW) and SIMD. The first implementation, MAJC 5200, includes some key features of MAJC to realize a high performance multimedia processor. Two CPUs running at 500 MHz are integrated into the chip to provide 6.16 GFLOPS and 12.33 GOPS with high speed interfaces providing a peak input-output (I/O) data rate of more than 4.8 GBytes/second. The chip is suitable for a number of applications including graphics/multimedia processing for high-end set-top boxes, digital voice processing for telecommunications, and advanced imaging.
Brute force searching, the typical set and Guesswork (2013)

Consider the situation where a word is chosen probabilistically from a finite list. If an attacker knows the list and can inquire about each word in turn, then selecting the word via the uniform distribution maximizes the attacker's difficulty, its Guesswork, in identifying the chosen word. It is tempting to use this property in cryptanalysis of computationally secure ciphers by assuming coded words are drawn from a source's typical set and so, for all intents and purposes, uniformly distributed within it. By applying recent results on Guesswork, for i.i.d. sources it is this equipartition ansatz that we investigate here. In particular, we demonstrate that the expected Guesswork for a source conditioned to create words in the typical set grows, with word length, at a lower exponential rate than that of the uniform approximation, suggesting use of the approximation is ill-advised.
Concetric circle 3D: optimization of salt diapir flank imaging, UK Central North Sea (1994)

Optimal imaging of reflection energy in steep dip structural environments requires that the data be acquired and processed in such a way that the primary reflections are stacked constructively, as well as correctly migrated. In certain structural situations special acquisition geometries can be employed which substantially contribute to the overall goal of enhanced imaging of the subsurface. In 1992 the first concentric circle 3D seismic survey was shot in the North Sea. The objective of the survey was to accurately image the flanks and the top of a salt diapir. The final processed dataset was compared to data acquired using 2D radial and conventional linear 3D survey techniques. The results indicate that the concentric circle 3D dataset appears to contain more information adjacent to the diapir flanks than either the 2D radial or conventionallinear 3D datasets.
CCD imaging for optical tomography of gel radiation dosimeters (1999)

Several investigations have been carried out by a number of researchers over the past few years to evaluate the utility of imaging gel dosimeters for the three-dimensional measurement of radiation fields. These have been proposed to be of particular value in mapping radiation dose distributions associated with emerging and complex approaches to cancer treatment such as conformal (CRT), intensity modulated (IMRT), "gamma knife," and pencil beam radiotherapies. Imaging of the gels has been successfully accomplished with clinical MRI units and via laser-based optical scanning. However, neither of these methods is generally accessible to all potential users, limiting the broader study and implementation of this valuable tool. We report here the design, methodology, and results of a preliminary study carried out to evaluate the utility of a new, inexpensive, and simplified approach to tomographic imaging of gel radiation dosimeters. For the purpose of this initial investigation, an array of liquid scintillation vials was prepared, containing a ferrous sulphate xylenol orange (FSX) gelatin formulation. The FSX formulation undergoes a change in optical absorption characteristics following irradiation, and the resulting color change can be observed visually. The vials were irradiated individually to different doses. Three-dimensional imaging was accomplished by tomographic reconstruction from two-dimensional optical images acquired using a diffuse, fluorescent light source, a digital charge-coupled device camera, single-photon-emission-computed tomography software, and other simple components designed by the authors. The resulting transverse images were evaluated through a region-of-interest (ROI) analysis to obtain the average change in image density in each vial as a function of radiation dose. These measured ROI values were subjected to a linear regression analysis to fit them to a straight line, and to determine the goodness of fit. Results from multiple imaging trials are compared. The correlation coefficients obtained are typically on the order of 0.98, and the p value from analysis of variance is approximately 0.05, indicating a linear and reproducible response for the dosimeter formulation and imaging system.
Strategic Entrepreneurship – Analyse der Strukturen und Entwicklung des Forschungsfeldes (2011)

Trotz des gemeinsamen Fokus haben sich die beiden akademischen Disziplinen Strategisches Ma nagement und Entrepreneurship im Wesentlichen voneinander unabhängig entwickelt. In Zeiten der Wirtschaftskrise und Ungewissheit hinsichtlich zukünftiger Entwicklungen gewinnen unternehmerische Strategien sowohl für Start-Ups als auch für etablierte Unternehmen zunehmend an Bedeutung. Aufgrund dieser Tatsache postulieren Forscher mit zunehmender Intensität die Integration der beiden Forschungsfelder. Zudem wurde die Verbindung bzw. Überschneidungen zwischen den beiden Forschungsfeldern bislang unzureichend untersucht. Das Ziel dieses Artikels stellt die Forcierung von Transparenz sowie eines klareren Verständnisses, basieren auf existierender Literatur, dar. Der vorliegende Artikel versucht die disponiblen Werke im aufkommenden Forschungsfeld Strategisches Entrepreneurship mit Hilfe einer Zitationsanalyse von zwischen 2001 und 2009 herausgegebenen Fachzeitschriftenartikeln zum Thema zu strukturieren sowie zu synthetisieren. Durch die Analyse von 1.309 Referenzen, die durch die Ausgangs-basis von 18 Artikeln zitiert wurden, konnten vier Themencluster identifiziert werden, auf denen die bislang publizierten Werke inhaltlich aufbauen. / Despite their shared focus, the two academic disciplines of strategic management and entrepreneurship have developed largely independently of each other. In times of economic crisis and uncertainty, entrepreneurial strategies are becoming more and more important for both new as well as established enterprises. Therefore scholars increasingly call for the integration of these two fields. Nevertheless, the evident intersection between these two research fields has been largely left uncovered so far. The objective of this article is to create a better understanding of this intersection, based on an aggregation of the extant literature in the two fields. This article attempts to structure and synthesize the existing scholarly works in the emerging field of Strategic Entrepreneurship by the means of a citation analysis of the articles published from 2001 to 2009 in academic journals on the topic. By analyzing 1,309 references cited in the initial basis of 18 articles, four cluster topics were identified that the emerging research field of SE is founded upon.
Optical Bandwidth Extension in Two Dimensions Beyond the Classical Limit* (1964)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text B. Morgenstern and D. P. Paris, "Optical Bandwidth Extension in Two Dimensions Beyond the Classical Limit*," J. Opt. Soc. Am. 54, 1282-1283 (1964) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Measurement of discrete vertical in-shoe stress with piezoelectric transducers (1988)

The purpose of this investigation was to design and validate a system suitable for non-invasive measurement of discrete in-shoe vertical plantar stress during dynamic activities. Eight transducers were constructed, with small piezoelectric ceramic squares (4.83 x 4.83 x 1.3 mm) used to generate a charge output proportional to vertical plantar stress. The mechanical properties of the transducers included 2.3% linearity and 3.7% hysteresis for stresses up to 2000 kPa and loading times up to 200 ms. System design efficacy was analysed by means of a multiple day, multiple trial data collection. With the transducers placed beneath plantar landmarks, the footstrike of one subject was recorded ten times on each of five days while running at 3.58 m/s on a treadmill. Within-day and between-day proportional error (PE) was used to estimate the error contained in the mean peak stress during foot contact. Within-day PE focused on trial to trial variability associated with the subject and equipment, and averaged 3.1% (range 2.5-4.0%) across transducer location. Between-day PE provided a cumulative estimate of subject, transducer placement, and random equipment variability, but excluded trial to trial variability. It ranged from 4.9 to 15.8%, with a mean of 9.9%. Peak stress, impulse, and sequence of loading data were examined to identify discrete foot function patterns and highlight the value of discrete stress analysis.
Enhanced Förster Resonance Energy Transfer on Single Metal Particle. 2. Dependence on Donor−Acceptor Separation Distance, Particle Size, and Distance from Metal Surface (2007)

We studied the effect of metal particles on Förster resonance energy transfer (FRET) between nearby donor-acceptor pairs. The studies included the effect of donor-acceptor distance, silver particle size, and distance from the metal surface. The metal particles were synthesized with average diameters of 15, 40, and 80 nm, respectively. A Cy5-labeled oligonucleotide was chemically bound to a single silver particle with a distance of 2 or 10 nm from the surface of metal core. A Cy5.5-labeled complementary oligonucleotide was bound to the particle-conjugated oligonucleotide by hybridization. The spacer length between donor-acceptor was adjusted by the number of base pairs. FRET between the donor-acceptor pair was investigated by dual-channel single-molecule fluorescence detection. Both the emission intensities and lifetimes indicated that FRET was enhanced efficiently by the metal particles. The results showed an increase of apparent energy transfer distance with the size of silver particle and distance from the metal core. Simulations by finite-difference time-domain (FDTD) calculations were used to compare with the experimental results. The local fields at the location of the donor-acceptor pair appeared to correlate with the FRET efficiency. These results will aid in the design of metal particles for using FRET to determine biomolecule proximity at distances beyond the usual Förster distance.