gebhart/patrepeval huggingface dataset:
Catalytic effect of tetrabutylammonium fluoride in the preparation of secoribo‐nucleosides (1989)

Abstract A general and rapid procedure is developed for the preparation of secoribo‐nucleoside analogues. Bu 4 NF has a marked effect on the condensation of guanine ( 5 ) with 2‐(chloromethoxy)ethyl benzoate ( 2 ) or 1‐halo‐2‐(chloromethoxy)ethanes 12 and 16 . Condensation and deprotection of the acyl protecting group and nucleophilic displacement of the halogen atoms to yield 9‐[(2‐hydroxyethoxy)methyl] guanine ( 9 ) occurred in one step.
Congenital central hypoventilation syndrome: Mutation analysis of the receptor tyrosine kinase RET (1996)

Congenital central hypoventilation syndrome (CCHS) usually occurs as an isolated phenotype. However, 16% of the index cases are also affected with Hirschsprung disease (HSCR). Complex segregation analysis suggests that CCHS is familial and has the same inheritance pattern with or without HSCR. We postulate that alteration of normal function of the receptor tyrosine kinase, RET, may contribute to CCHS based on RET's expression pattern and the identification of RET mutations in HSCR patients. To further explore the nature of the inheritance of CCHS, we have undertaken two main routes of investigation: cytogenetic analysis and mutation detection. Cytogenetic analysis of metaphase chromosomes showed normal karyotypes in 13 of the 14 evaluated index cases; one index case carried a familial pericentric inversion on chromosome 2. Mutation analysis showed no sequence changes unique to index cases, as compared to control individuals, and as studied by single strand conformational polymorphism (SSCP) analysis of the coding region of RET. We conclude that point mutations in the RET coding region cannot account for a substantial fraction of CCHS in this patient population, and that other candidate genes involved in neural crest cell differentiation and development must be considered.
Analysis of Demand for Dairy Product in Central American Countries under the CAFTA (2015)

A double-log model was estimated on demand for cheese and fluid milk and for the aggregation of imported cheese, fluid milk, and powdered milk in Costa Rica, El Salvador, Guatemala, Honduras, and Nicaragua using time series data 1994-2012. Cheese and fluid milk were price and income inelastic in all countries, except for income in El Salvador. On the other hand, import prices for cheese and fluid milk were often found elastic, but that of powdered milk was inelastic. An increase in incomes augmented imports of fluid milk and cheese, compared to powdered milk. Overall, the substitution effect suggested that increment in imports prices of cheese and fluid milk increased the purchase of powdered milk.
Expression of Rous sarcoma virus transforming protein pp60v-src in Saccharomyces cerevisiae cells. (1987)

The Rous sarcoma virus (RSV) pp60v-src protein was expressed in Saccharomyces cerevisiae cells either from a plasmid vector carrying the v-src gene or in yeast cells containing a single-copy v-src gene chromosomally integrated. In both yeast strains, v-src gene transcription is regulated by the galactose-inducible GAL10 promoter. Growth in galactose-containing medium resulted in constitutive expression of pp60v-src in the integrated strain and transient expression of higher levels of pp60v-src in the plasmid-bearing strain. The concentration of pp60v-src in the plasmid-bearing strain at its peak of expression was approximately threefold lower than that found in RSV-transformed mammalian cells. pp60v-src synthesized in yeast cells was phosphorylated in vivo on sites within the amino and carboxyl halves of the molecule. In immune complex kinase assays, the yeast pp60v-src was autophosphorylated on tyrosine and was able to phosphorylate exogenous substrates such as casein and enolase. The specific activity of pp60v-src synthesized in yeast cells was approximately 5- to 10-fold higher than that made in mammalian cells. Induction of pp60v-src caused the death of the plasmid-bearing yeast strain and transient inhibition of growth of the single-copy strain. Concomitantly, this induction resulted in high levels of tyrosine phosphorylation of yeast cell proteins. This indicates that pp60v-src functions as a tyrosine-specific phosphotransferase in yeast cells and suggests that hyperphosphorylation of yeast proteins is inimical to cell growth.
The Symmetric Perturbation of a Spherical Cavity† (1967)

ABSTRACT Group-theoretical methods are applied to the calculation of the eigen-frequencies and eigenvectors of a spherical cavity, which is perturbed by a boundary modification of definite symmetry. A first-order perturbation theory is developed, which can be applied to the degenerate sets of modes associated with the spherical cavity. An example of D2 symmetry is discussed in detail, and practical applications are suggested.
Character recognition in a sparse distributed memory (1991)

P. Kanerva's (1988) sparse distributed memory model is applied to character recognition. The results of recognizing corrupted characters, using a sparse distributed memory with fewer than 10000 locations, is described: 100 corrupted test patterns were generated to recognize 18 template patterns. The performance of the model is evaluated. Insights about the behavior of sparse distributed memories as well as the model's applicability to character recognition are provided. It was found that a sparse distributed memory of small size can recognize patterns with considerable noise.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Unbiased Scene Graph Generation from Biased Training (2020)

Today's scene graph generation (SGG) task is still far from practical, mainly due to the severe training bias, e.g., collapsing diverse "human walk on / sit on / lay on beach" into "human on beach". Given such SGG, the down-stream tasks such as VQA can hardly infer better scene structures than merely a bag of objects. However, debiasing in SGG is not trivial because traditional debiasing methods cannot distinguish between the good and bad bias, e.g., good context prior (e.g., "person read book" rather than "eat") and bad long-tailed bias (e.g., "near" dominating "behind / in front of"). In this paper, we present a novel SGG framework based on causal inference but not the conventional likelihood. We first build a causal graph for SGG, and perform traditional biased training with the graph. Then, we propose to draw the counterfactual causality from the trained graph to infer the effect from the bad bias, which should be removed. In particular, we use Total Direct Effect (TDE) as the proposed final predicate score for unbiased SGG. Note that our framework is agnostic to any SGG model and thus can be widely applied in the community who seeks unbiased predictions. By using the proposed Scene Graph Diagnosis toolkit on the SGG benchmark Visual Genome and several prevailing models, we observed significant improvements over the previous state-of-the-art methods.
Electrolytic Destruction of Lung Tissue in the Rabbit (1980)

Tissue destruction was produced by electrolysis after insertion of electrodes into the rabbit lung. The anode was the active electrode and the best electrode material was platinum. The lesions formed around the electrode were well demarcated and their size varied in relation to the charge applied. Complications were few and the lesions healed quickly. Tissue injury occurs as the result of chlorine liberation at the anode, the basis for which is chloride ion oxidation.
The c-kit Ligand, Stem Cell Factor, Can Enhance Innate Immunity Through Effects on Mast Cells (1998)

Mast cells are thought to contribute significantly to the pathology and mortality associated with anaphylaxis and other allergic disorders. However, studies using genetically mast cell-deficient WBB6F1-KitW/KitW-v and congenic wild-type (WBB6F1-+/+) mice indicate that mast cells can also promote health, by participating in natural immune responses to bacterial infection. We previously reported that repetitive administration of the c-kit ligand, stem cell factor (SCF), can increase mast cell numbers in normal mice in vivo. In vitro studies have indicated that SCF can also modulate mast cell effector function. We now report that treatment with SCF can significantly improve the survival of normal C57BL/6 mice in a model of acute bacterial peritonitis, cecal ligation and puncture (CLP). Experiments in mast cell-reconstituted WBB6F1-KitW/KitW-v mice indicate that this effect of SCF treatment reflects, at least in part, the actions of SCF on mast cells. Repetitive administration of SCF also can enhance survival in mice that genetically lack tumor necrosis factor (TNF)-alpha, demonstrating that the ability of SCF treatment to improve survival after CLP does not solely reflect effects of SCF on mast cell- dependent (or -independent) production of TNF-alpha. These findings identify c-kit and mast cells as potential therapeutic targets for enhancing innate immune responses.
High-Speed Optical Wireless Communication System for Indoor Applications (2011)

A novel high-speed optical wireless communication system for indoor personal area networking applications is proposed and studied. A proof-of-concept experiment at 12.5-Gb/s wireless transmission has been successfully demonstrated with limited mobility. When integrated with a WiFi-based localization system, high-speed optical wireless communication with a mobility feature can be achieved over the entire room. The performance trade-offs between the maximum beam footprint and overall bit rate have also been studied and quantified experimentally and the results show that error-free (BER<;10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> ) reception can always be achieved for a wide range of bit rates from 1 to 12.5 Gb/s.
Display Holography's Digital Second Act (2012)

Holography, with its stunning 3-D realism and its expressive potential, in the 1970s and 1980s seemed poised to become the next step in the evolution of visual display. Yet apart from certain specialized niches, display holograms are perhaps more rarely encountered in everyday life than they were 20 or 30 years ago. But the recent resurgence of interest in 3-D video for entertainment applications has underlined the limitations of left/right stereoscopic imaging and created a desire for more natural 3-D imagery in which no glasses are required and all perceptual cues to depth are provided in a consistent fashion. Could holography-whose transition from darkroom to digital has taken some years longer than that of photography-capitalize on this opportunity? In this paper, I examine digital developments in holographic printing, holographic projection, and holographic television, and explore connections between holographic imaging and areas such as integral imaging and telepresence.
Use of keratin antibodies in tumor diagnosis. (1990)

The tissue specific expression shown by intermediate filament proteins, their ease of extraction and their antigenicity has led to the use intermediate filament antibodies in diagnostic pathology, particularly antibodies to keratin intermediate filaments because of the predominant involvement of epithelia in cancers. We review the principles of differentiation-specific keratin expression and detail 100 of the best-known monoclonal antibodies to keratins which are currently in use: in many circumstances antibodies can now be reliably used as in situ markers of keratin expression. We also suggest a database scheme for better dissemination of information on available monoclonal antibodies to keratins in the future.
Neuronal release of D‐serine: a physiological pathway controlling extracellular D‐serine concentration (2010)

D-serine is thought to be a glia-derived transmitter that activates N-methyl D-aspartate receptors (NMDARs) in the brain. Here, we investigate the pathways for D-serine release using primary cultures, brain slices, and in vivo microdialysis. In contrast with the notion that D-serine is exclusively released from astrocytes, we found that D-serine is released by neuronal depolarization both in vitro and in vivo. Veratridine (50 microM) or depolarization by 40 mM KCl elicits a significant release of endogenous D-serine from primary neuronal cultures. Controls with astrocyte cultures indicate that glial cells are insensitive to veratridine, but release D-serine mainly by the opening of volume-regulated anion channels. In cortical slices perfused with veratridine, endogenous D-serine release is 10-fold higher than glutamate receptor-evoked release. Release of D-serine from slices does not require internal or external Ca(2+), suggesting a nonvesicular release mechanism. To confirm the neuronal origin of D-serine, we selectively loaded neurons in cortical slices with D-[(3)H]serine or applied D-alanine, which specifically releases D-serine from neurons. Depolarization with veratridine promotes D-serine release in vivo monitored by high temporal resolution microdialysis of the striatum. Our data indicate that the neuronal pool of D-serine plays a major role in D-serine dynamics, with implications for the regulation of NMDAR transmission.
Dam monitoring using combined terrestrial imaging systems (2009)

Abstract: Thousands of registered large concrete and embankment dams have now more than five decades of operation and age related problems. Structural safety condition assessment is the main aim of dam monitoring activities and a concern for authorities. Laser scanners combined with digital calibrated reflex cameras provide accurate and very dense 3D numerical models as well as spatially continuous high-resolution RGB information of the objects under study. These combined terrestrial imaging systems (CTIS) provide a huge amount of geometric and radiometric well structured data in a short period of time. A 3D scanning company, Artescan, and a research organization (LNEC, Laboratório Nacional de Engenharia Civil, in Portugal) have been, since 2003, developing positional monitoring methodologies for embankment dams and assisted visual inspection methodologies for concrete dams. Interesting results have been achieved in what concerns positional accuracy, system reliability and cost-effectiveness of this approach to enhance dam monitoring capabilities. This paper presents different examples of the developed methodologies as applied to dam monitoring. 1.
A Critical Review of Naphthalene Sources and Exposures Relevant to Indoor and Outdoor Air (2010)

Both the recent classification of naphthalene as a possible human carcinogen and its ubiquitous presence motivate this critical review of naphthalene's sources and exposures. We evaluate the environmental literature on naphthalene published since 1990, drawing on nearly 150 studies that report emissions and concentrations in indoor, outdoor and personal air. While naphthalene is both a volatile organic compound and a polycyclic aromatic hydrocarbon, concentrations and exposures are poorly characterized relative to many other pollutants. Most airborne emissions result from combustion, and key sources include industry, open burning, tailpipe emissions, and cigarettes. The second largest source is off-gassing, specifically from naphthalene's use as a deodorizer, repellent and fumigant. In the U.S., naphthalene's use as a moth repellant has been reduced in favor of para-dichlorobenzene, but extensive use continues in mothballs, which appears responsible for some of the highest indoor exposures, along with off-label uses. Among the studies judged to be representative, average concentrations ranged from 0.18 to 1.7 microg m(-3) in non-smoker's homes, and from 0.02 to 0.31 microg m(-3) outdoors in urban areas. Personal exposures have been reported in only three European studies. Indoor sources are the major contributor to (non-occupational) exposure. While its central tendencies fall well below guideline levels relevant to acute health impacts, several studies have reported maximum concentrations exceeding 100 microg m(-3), far above guideline levels. Using current but draft estimates of cancer risks, naphthalene is a major environmental risk driver, with typical individual risk levels in the 10(-4) range, which is high and notable given that millions of individuals are exposed. Several factors influence indoor and outdoor concentrations, but the literature is inconsistent on their effects. Further investigation is needed to better characterize naphthalene's sources and exposures, especially for indoor and personal measurements.
DELETERIOUS EFFECTS OF DELAYED GRAFT FUNCTION IN CADAVERIC RENAL TRANSPLANT RECIPIENTS INDEPENDENT OF ACUTE REJECTION1,2,3 (1998)

DGF is an important independent predictor of poor graft survival. Newer immunosuppressive strategies must minimize nonimmune and immune renal injury if long-term graft survival is to improve.
Arabidopsis <i>glabra2</i> mutant seeds deficient in mucilage biosynthesis produce more oil (2011)

Seed oil, one of the major seed storage compounds in plants, is of great economic importance for human consumption, as an industrial raw material and as a source of biofuels. Thus, improving the seed oil yield in crops is an important objective. The GLABRA2 (GL2) gene in Arabidopsis thaliana encodes a transcription factor that is required for the proper differentiation of several epidermal cell types. GL2 has also been shown to regulate seed oil levels, as a loss-of-function mutation in the GL2 gene results in plants with a higher seed oil content than wild-type. We have extended this observation by showing that loss-of-function mutations in several positive regulators of GL2 also result in a high seed oil phenotype. The GL2 gene is expressed in both the seed coat and embryo, but the embryo is the main site of seed oil accumulation. Surprisingly, our results indicate that it is loss of GL2 activity in the seed coat, not the embryo, that contributes to the high seed oil phenotype. One target of GL2 in the seed coat is the gene MUCILAGE MODIFIED 4 (MUM4), which encodes a rhamnose synthase that is required for seed mucilage biosynthesis. We found that mum4 mutant seeds, like those of gl2 mutants, have an increased seed oil content in comparison with wild-type. Therefore, GL2 regulates seed oil production at least partly through its influence on MUM4 expression in the seed coat. We propose that gl2 mutant seeds produce more oil due to increased carbon allocation to the embryo in the absence of seed coat mucilage biosynthesis.
The scanning electron microscope (1967)

The scanning electron microscope combines the techniques of the cathode-ray tube and the conventional electron microscope-both considered indispensable to modern technology. The SEM, which presents a picture having a distinct three-dimensional appearance, is finding application in the examination of wood fibers in connection with paper manufacture, of surfaces undergoing ionic bombardment, and of corrosion. At the present time, one of the most pressing problems is to reduce its total cost.
Percutaneous Absorption, Excretion and Metabolism of All-<i>trans</i>-Retinoyl β-Glucuronide and of AII-<i>trans</i>-Retinoic Acid in the Rat (1996)

The purpose of these studies was to compare directly the percutaneous absorption,excretion and metabolism of all-trans-retinoyl beta-glucuronide (RAG), a nontoxic retinoid, with all-trans-retinoic acid (RA) in the rat. Previously, it was demonstrated that topical treatment of human acne with either RAG or RA in cream resulted in a significant reduction of lesions. Whereas 0.1% RA showed adverse effects, concentrations of RAG up to 2.4% did not cause any adverse reactions. In the present studies, radiolabeled RAG or RA, dispersed in a water-based cream, was applied to the shaved dorsal skin of vitamin A-sufficient rats. Both RAG and RA were absorbed from the skin in a similar way. In both cases, radioactivity peaked in the plasma within 2-4 h and within the liver at 4-12 h. During a 7-day period, the overall excretion of radioactivity derived from RA and RAG in the feces and urine were similar, e.g. 17 and 12%, respectively. it is concluded that: (1) the transport, metabolism and excretion of topically applied radioactive RA and RAG are similar, although not identical, in the rat and (2) the toxic skin manifestations induced by RA but not by RAG cannot be attributed to major differences in their overall absorption, metabolism and excretion.
Does halting make hardware trace collection inaccurate? a study using pentium 4 performance counters and SPEC2000 (2005)

Processor address traces are invaluable for characterizing workloads and testing proposed memory hierarchies. Long traces are needed to exercise modern cache designs and produce meaningful results, but are difficult to collect with hardware monitors because microprocessors access memory too frequently for disks or other large storage to keep up. The small, fast buffers of the monitors fill quickly; in order to obtain long contiguous traces, the processor must be stopped while the buffer is emptied. This halting may perturb the traces collected, but this cannot be measured directly, since long uninterrupted traces cannot be collected. We make the case that hardware performance counters, which collect runtime statistics without influencing execution, can be used to measure halting effects. We use the performance counters of the Pentium 4 processor to collect statistics while halting the processor as if traces were being collected. We then compare these results to the statistics obtained from unhalted runs. We present our results in terms of which counters are affected, why, and what this means for trace-collection systems.
Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation (2010)

Increasing evidence shows that reactive oxygen species (ROS) may be critical mediators of liver damage during the relative hypoxia of ischemia/reperfusion injury (IRI) associated with transplant surgery or of the tissue microenvironment created as a result of chronic hepatic inflammation or infection. Much work has been focused on Kupffer cells or liver resident macrophages with respect to the generation of ROS during IRI. However, little is known about the contribution of endogenous hepatocyte ROS production or its potential impact on the parenchymal cell death associated with IRI and chronic hepatic inflammation. For the first time, we show that human hepatocytes isolated from nondiseased liver tissue and human hepatocytes isolated from diseased liver tissue exhibit marked differences in ROS production in response to hypoxia/reoxygenation (H-R). Furthermore, several different antioxidants are able to abrogate hepatocyte ROS-induced cell death during hypoxia and H-R. These data provide clear evidence that endogenous ROS production by mitochondria and nicotinamide adenine dinucleotide phosphate oxidase drives human hepatocyte apoptosis and necrosis during hypoxia and H-R and may therefore play an important role in any hepatic diseases characterized by a relatively hypoxic liver microenvironment. In conclusion, these data strongly suggest that hepatocytes and hepatocyte-derived ROS are active participants driving hepatic inflammation. These novel findings highlight important functional/metabolic differences between hepatocytes isolated from normal donor livers, hepatocytes isolated from normal resected tissue obtained during surgery for malignant neoplasms, and hepatocytes isolated from livers with end-stage disease. Furthermore, the targeting of hepatocyte ROS generation with antioxidants may offer therapeutic potential for the adjunctive treatment of IRI and chronic inflammatory liver diseases.