gebhart/patrepeval huggingface dataset:
[Expression of cystic fibrosis transmembrane conductance regulator in human endometrium]. (2004)

The expression of CFTR in human endometrium presented in glandular cells and the amounts were varied cyclically. The abundant CFTR mRNAs and proteins around the ovulatory period may drive Na(+) and fluid from plasma into the uterine lumen to make optimal electrolyte composition and sufficient fluid volume for sperm migration.
Surgical Treatment of Mitral Insufficiency by Total Circumferential "Purse-String" Suture of the Mitral Ring (1957)

A new surgical procedure for correction of mitral insufficiency is presented. The clinical and hemodynamic results in 12 cases are discussed.
Angiogenic Factors in the Central Nervous System (2003)

The past decade has seen considerable advances in the understanding of angiogenesis. Blood vessel development and growth in the central nervous system are tightly controlled processes that are regulated by angiogenic factors. Angiogenic factors have been implicated in the pathogenesis of a wide variety of disorders, including primary and metastatic brain tumors, aneurysms, arteriovenous malformations, and cavernous malformations. The potential clinical applications of angiogenesis research include inhibition of angiogenesis to control brain tumors and therapeutic angiogenesis to promote collateral blood vessel formation among patients at risk of ischemia. This article summarizes the processes of blood vessel formation in the brain, examines the angiogenic factors that are prominent in the central nervous system, reviews the clinical use of angiogenesis inhibitors, and identifies areas for future investigation.
Energy efficiency analysis of small cell networks (2013)

Small cell networks have recently been proposed as an important evolution path for the next-generation cellular networks. While such approach has the potential of meeting the growing network throughput requirement, the energy efficiency of small cell networks is of great concern as the base station (BS) density will be significantly increased. The objective of this paper is to analyze the energy efficiency in small cell networks. To do so, we adopt a random spatial network model, where BSs and users are modeled as two independent spatial Poisson point processes (PPPs). We shall derive analytical results for the network energy efficiency, which show that the BS power consumption model plays a critical role. In particular, it will be shown that increasing the BS density can actually improve the energy efficiency if the BS power consumption that is not related to signal transmission is less than a certain threshold. By comparing the cases between single-antenna and multi-antenna BSs, we find that single-antenna BSs provide a higher energy efficiency if the circuit power is larger than a threshold. Simulation results will demonstrate that our conclusions which are based on the random network model also hold in a regular grid-based model.
Concentration—Response Relationships of Sweeteners (1991)

Sweetness intensity ratings were made by a trained panel for a range of concentrations of nineteen sweeteners. Panelists were trained to make sweetness ratings relative to six sucrose standards (2%-16%). The shapes of the concentration-response plots were sweetener-dependent. Sugars and sugar alcohols yielded linear concentration-response relationships for intensities up to that of a 16% sucrose standard. Highpotency sweeteners including aspartame, acesulfame-K and alitame yielded hyperbolic concentration-response plots.
Self-holding photochromic polymer Mach–Zehnder optical switch (1994)

A self-holding and optical–optical 2×2 switch using a Mach–Zehnder interferometer with a thermally irreversible photochromic (PC) guest/host polymer cladding is reported. The device was fabricated using a silica-based integrated optic Mach–Zehnder interferometer with a PC cladding polymer. Cross-bar switching was achieved by using ultraviolet (313 nm) and visible (≳500 nm) light. The switching state was self-holding in the dark. Switching was observed with a crosstalk ratio of −12 dB and an excess loss of 7 dB at 1.55 μm.
Bruxelles 2000: un cadre d’ajustements (2000)

Reprise sous une forme légèrement modifiée
Current paths and electrolysis efficiency in bipolar packed-bed electrodes. (1982)

The characteristics of bipolar packed-bed electrodes were studied by using copper deposition reaction from a copper sulfate solution. Ferrite pellets were used as a particulate phase and were packed in three kinds of mode. The Faradaic current in the particulate phase, the by-pass current in the electrolyte phase and the short-circuiting current were measured separately. The minimum bipolar cell voltage was a function of decomposition voltage, distance between two plate electrodes, pellet diameter, and solid holdup. For regularly packed bipolar electrodes, the interaction between Faradaic and by-pass current was small, and a simplified parallel current model is proposed. For randomly packed bipolar electrodes, the interaction was not negligible at higher cell voltages. The minimum value of energy consumption was observed at a particular cell voltage which was a function of pellet size and packing mode. Because of increase in the short-circuiting current due to copper deposition, the energy consumption in the randomly packed bed increased with increase in electrolysis time. The regularly packed bed where the direction of current was parallel to the plain faces of the pellets was found to be the most efficient under the present experimental conditions.
Development and calibration of a load sensing cervical distractor capable of withstanding autoclave sterilization (2004)

In surgery of the cervical spine, a Caspar pin distractor is often used to apply a tensile load to the spine in order to open up the disc space. This is often done in order to place a graft or other interbody fusion device in the spine. Ideally a tight interference fit is achieved. If the spine is over distracted, allowing for a large graft, there is an increased risk of subsidence into the endplate. If there is too little distraction, there is an increased risk of graft dislodgement or pseudoarthrosis. Generally, graft height is selected from preoperative measurements and observed distraction without knowing the intraoperative compressive load. This device was designed to give the surgeon an assessment of this applied load. Instrumentation of the device involved the application of strain gauges and the selection of materials that would survive standard autoclave sterilization. The device was calibrated, sterilized and once again calibrated to demonstrate its suitability for surgical use. Results demonstrate excellent linearity in the calibration, and no difference was detected in the pre- and post-sterilization calibrations.
Simple Working Key for the Classification and Identification of Named Taxa Included in the International Streptomyces Project (1972)

A simple diagnostic key, consisting of 13 tables, for the classification and identification of 274 named taxa included in the International Streptomyces Project (ISP) is presented. By means of the few criteria used in the ISP studies it is possible to identify organisms belonging to most of the named species included in that study. In a few cases, additional characters are required.
Paranodal junction formation and spermatogenesis require sulfoglycolipids (2002)

Mammalian sulfoglycolipids comprise two major members, sulfatide (HSO3-3-galactosylceramide) and seminolipid (HSO3-3-monogalactosylalkylacylglycerol). Sulfatide is a major lipid component of the myelin sheath and serves as the epitope for the well known oligodendrocyte-marker antibody O4. Seminolipid is synthesized in spermatocytes and maintained in the subsequent germ cell stages. Both sulfoglycolipids can be synthesized in vitro by using the isolated cerebroside sulfotransferase. To investigate the physiological role of sulfoglycolipids and to determine whether sulfatide and seminolipid are biosynthesized in vivo by a single sulfotransferase, Cst-null mice were generated by gene targeting. Cst(-/-) mice lacked sulfatide in brain and seminolipid in testis, proving that a single gene copy is responsible for their biosynthesis. Cst(-/-) mice were born healthy, but began to display hindlimb weakness by 6 weeks of age and subsequently showed a pronounced tremor and progressive ataxia. Although compact myelin was preserved, Cst(-/-) mice displayed abnormalities in paranodal junctions. On the other hand, Cst(-/-) males were sterile because of a block in spermatogenesis before the first meiotic division, whereas females were able to breed. These data show a critical role for sulfoglycolipids in myelin function and spermatogenesis.
Adaptive nearest neighbor pattern classification (1991)

A variant of nearest-neighbor (NN) pattern classification and supervised learning by learning vector quantization (LVQ) is described. The decision surface mapping method (DSM) is a fast supervised learning algorithm and is a member of the LVQ family of algorithms. A relatively small number of prototypes are selected from a training set of correctly classified samples. The training set is then used to adapt these prototypes to map the decision surface separating the classes. This algorithm is compared with NN pattern classification, learning vector quantization, and a two-layer perceptron trained by error backpropagation. When the class boundaries are sharply defined (i.e., no classification error in the training set), the DSM algorithm outperforms these methods with respect to error rates, learning rates, and the number of prototypes required to describe class boundaries.
Crystal Structure of the Measles Virus Nucleoprotein Core in Complex with an N-Terminal Region of Phosphoprotein (2015)

Measles virus is an important, highly contagious human pathogen. The nucleoprotein N binds only to viral genomic RNA and forms the helical ribonucleocapsid that serves as a template for viral replication. We address how N is regulated by another protein, the phosphoprotein (P), to prevent newly synthesized N from binding to cellular RNA. We describe the atomic model of an N-P complex and compare it to helical ribonucleocapsid. We thus provide insight into how P chaperones N and helps to start viral RNA synthesis. Our results provide a new insight into mechanisms of paramyxovirus replication. New data on the mechanisms of phosphoprotein chaperone action allows better understanding of virus genome replication and nucleocapsid assembly. We describe a conserved structural interface for the N-P interaction which could be a target for drug development to treat not only measles but also potentially other paramyxovirus diseases.
Specific Temporal Profile of Matrix Metalloproteinase Release Occurs in Patients After Myocardial Infarction (2006)

A specific temporal pattern of MMP/TIMPs occurred in post-MI patients that included an early and robust rise in MMP-9 and MMP-8 and a uniform fall in TIMP-4. These findings suggest that a specific MMP/TIMP plasma profile occurs after MI and holds both prognostic and diagnostic significance.
Determination of the Active Site Protonation State of β-Secretase from Molecular Dynamics Simulation and Docking Experiment:  Implications for Structure-Based Inhibitor Design (2003)

Memapsin 2 (BACE) is an aspartyl protease known as beta-secretase that acts on the production of the beta-amyloid peptide in the human brain, a key event in the pathogenesis of Alzheimer's disease. Although it is expected that the net charge of the catalytic Asp diad would be -1 as in other kinds of aspartyl proteases, the exact protonation states of Asp32 and Asp228 have not been known without ambiguity. Two independent molecular dynamics (MD) simulations of BACE in complex with the potent inhibitor OM99-2 are carried out to determine the preferred protonation state of the Asp diad in the context that is consistent with the previous X-ray crystal structure. The results show that a strong hydrogen bond between the inhibitor hydroxyl group and Asp228 can be maintained only when Asp32 is neutral and Asp228 is ionized. The preference of this protonation state is further supported from the energetic and structural features found in the docking experiment of a novel potent inhibitor with the BACE active site. Thus, both MD and docking studies suggest that the role of hydrogen bond acceptor for the hydroxyl and piperazine groups of the inhibitors should be played by Asp228 instead of Asp32. This may be a key piece of information for the structure-based design/discovery of new inhibitor drugs.
Carbodiimide Insertion into Organoaluminum Compounds and Thermal Rearrangement of the Products (1998)

A series of carbodiimide insertion products were prepared using various aluminum reagents (viz., AlR3 (R = Me, Et), AlX2Y (X = Cl, R; Y = Cl, NR'2)) and 1,3-diisopropyl- and 1,3-di-tert-butylcarbodiimides in various stoichiometric ratios. The resulting products 1−20 were isolated either as colorless liquids or as solids. These compounds were characterized by 1H NMR, 13C NMR, IR, and mass spectral data. Elemental analysis data for some of the representative compounds were obtained. The crystal structures of two of the compounds (compounds 8'' and 10) were determined by single-crystal X-ray diffraction. The competitive migration of the alkyl, chloro, or amino group attached to the aluminum atom onto the carbon of the carbodiimide is also reported.
Volksheelkunde in den Indischen Archipel (1915)

De behoefte dood den
EGFR, HER2 and Kras as predictive factors for cetuximab sensitivity in colorectal cancer (2007)

4021 Background: In colorectal cancer, biological mechanisms underlying response or resistance to cetuximab, a monoclonal antibody against the extracellular domain of the EGFR are not defined. Small retrospective studies suggested that EGFR increased gene copy number measured by fluorescence in situ hybridization (FISH) or presence of KRAS mutations were associated with cetuximab response or resistance, respectively. This study aimed to identify biological predictors for sensitivity/resistance to cetuximab treatment in colorectal cancer. We also compared biomarker results in primary tumors and corresponding metastases. Methods: We analyzed EGFR (IHC, FISH), HER2 (FISH), and KRAS (mutation) in paraffin embedded tumor blocks from 85 colorectal cancer patients treated with cetuximab. For FISH analyses, a positive result was defined according to criteria described in breast (Wolff et al. J Clin Oncol 2007), lung (Cappuzzo et al. JNCI 2005) and colorectal cancer (Moroni et al. Lancet Oncology 2005). EGFR, HER2 and PIK3CA mutation analyses are ongoing. Results: EGFR FISH positive patients (N=41), defined as ratio EGFR/nucleus =3, had a significantly higher RR (29.3% versus 6.8%, p=0.007) and TTP (6.6 versus 3.7 months, p=0.053) than EGFR FISH negative (N=44). No difference for clinical endpoints was observed using other scoring systems. EGFR expression assessed by IHC was not associated with any clinical end-point. Increased HER2 gene copy number was associated with shorter TTP (p=0.09) and survival (p=0.03). Compared to patients with wild type KRAS (N=49), KRAS mutation carriers (N=32) had a significantly lower RR (6.3% versus 26.5%, p= 0.02), shorter TTP (3.7 versus 6.3 months, p=0.07) and shorter survival (8.3 versus 10.8 months, p=0.2). In 22 patients with available primary and metastatic tumor tissue, there was no difference between these sites for EGFR FISH, HER2 FISH and KRAS results. Conclusions: This study, the largest biomarker analysis in colorectal cancer patients treated with cetuximab, shows a significant benefit in response and TTP for EGFR FISH positive patients. KRAS mutation analysis identifies a group of patients with the lowest chance to benefit from the therapy. Increased HER2 gene copy number predicts early escape from cetuximab therapy. No significant financial relationships to disclose.
Artificial annelid robot driven by soft actuators (2007)

The annelid provides a biological solution of effective locomotion adaptable to a large variety of unstructured environmental conditions. The undulated locomotion of the segmented body in the annelid is characterized by the combination of individual motion of the muscles distributed along the body, which has been of keen interest in biomimetic investigation. In this paper, we present an annelid-like robot driven by soft actuators based on dielectric elastomer. To mimic the unique motion of the annelid, a novel actuation method employing dielectric elastomer is developed. By using the actuator, a three-degree-of-freedom actuator module is presented, which can provide up-down translational motion, and two rotational degree-of-freedom motion. The proposed actuation method provides advantageous features of reduction in size, fast response and ruggedness in operation. By serially connecting the actuator modules, a micro-robot mimicking the motion of the annelid is developed and its effectiveness is experimentally demonstrated.
Policy based electronic transmission of prescriptions (2004)

We describe the PERMIS PMI role based authorisation policy, and show how it has been applied to the electronic transfer of prescriptions (ETP). The assignment of roles is distributed to the appropriate authorities in the health care and government sectors. This includes the assignment of both professional roles such as doctor and dentist, as well as patient roles that entitle patients to free prescriptions. All roles are stored as X.509 attribute certificates (ACs) in LDAP directories, which are managed by the assigning authorities. The PERMIS policy based decision engine subsequently retrieves these role ACs in order to make granted or denied access control decisions required by the ETP applications. The source of authority for setting the ETP policy is assumed to be the Secretary of State for Health. The ETP policy says what roles are recognised, who is authorised to assign the roles, what privileges are granted to each role and what conditions are attached to these privileges. The ETP policy is then formatted in XML, embedded in an X.509 attribute certificate, digitally signed by the Secretary of State for Health, and then stored in an LDAP directory. From here it can be accessed by all the ETP applications in the UK National Health Service that contain embedded policy based PERMIS decision engines.
Nested Effects (1995)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Analysis of Volatile Compounds in Exhaled Breath Condensate in Patients with Severe Pulmonary Arterial Hypertension (2014)

These findings indicate the utility of EBC VOC analysis to discriminate between severe IPAH and a healthy population; additionally, we identified potential novel biomarkers that correlated with IPAH pulmonary hemodynamic variables that may be important in screening for less severe forms IPAH.
A General Neural Network Hardware Architecture on FPGA (2017)

Field Programmable Gate Arrays (FPGAs) plays an increasingly important role in data sampling and processing industries due to its highly parallel architecture, low power consumption, and flexibility in custom algorithms. Especially, in the artificial intelligence field, for training and implement the neural networks and machine learning algorithms, high energy efficiency hardware implement and massively parallel computing capacity are heavily demanded. Therefore, many global companies have applied FPGAs into AI and Machine learning fields such as autonomous driving and Automatic Spoken Language Recognition (Baidu) [1] [2] and Bing search (Microsoft) [3]. Considering the FPGAs great potential in these fields, we tend to implement a general neural network hardware architecture on XILINX ZU9CG System On Chip (SOC) platform [4], which contains abundant hardware resource and powerful processing capacity. The general neural network architecture on the FPGA SOC platform can perform forward and backward algorithms in deep neural networks (DNN) with high performance and easily be adjusted according to the type and scale of the neural networks.
How well can data temporal consistency be maintained? (2003)

A model of hard real-time systems where tasks access shared data is presented, and temporal consistency is defined in terms of the age and dispersion of data. Based on this model, two variants of a multiversion lock-based concurrency control algorithm and two priority-driven preemptive scheduling algorithms, rate-monotone and earliest-deadline-first, are evaluated. Simulation results indicate how well data temporal consistency is maintained for different workload characteristics. These results can be used to guide the design of applications; by avoiding undesirable parameters, it is made easier to maintain data temporal consistency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dual Targeting of EWS-FLI1 Activity and the Associated DNA Damage Response with Trabectedin and SN38 Synergistically Inhibits Ewing Sarcoma Cell Growth (2013)

These results provide the basis and rationale for translating this drug combination to the clinic. In addition, the study highlights an approach that utilizes a targeted agent to interfere with an oncogenic transcription factor and then exploits the resulting changes in gene expression to develop a molecularly targeted combination therapy.
Friendly-Jamming: An Anti-Eavesdropping Scheme in Wireless Networks of Things (2016)

In this paper, we propose a novel anti- eavesdropping scheme by introducing friendly jammers to a wireless network of things (WNoT). In particular, we establish a theoretical framework to evaluate the eavesdropping risk of WNoT with friendly jammers and the eavesdropping risk of WNoT without jammers. Our theoretical model takes into account various channel conditions such as the path loss and Rayleigh fading as well as the placement schemes of jammers. Our extensive numerical results show that using jammers in WNoT can effectively reduce the eavesdropping risk. Besides, our results also show that the eavesdropping risk heavily depends on both the channel conditions and the placements of jammers.
Media processor core architecture for realtime, bi-directional MPEG4/H.26X codec with 30 fr/s for CIF-video (2002)

We have developed a media processor core for MPEG4/H.26X codec LSI, which realizes a real-time bi-directional encoding/decoding for CIF-resolution video at the frame rate of 30 fr/s. The core processor contains 6.3 M-transistors on only 14 mm silicon area and consumes 280 mW at 1.8 V. It features an MPEG-oriented hybrid architecture which incorporates a SIMD processor optimized for matrix-operation, a programmable VLC engine and two-dimensional multifunction DMA. Another features are a memory reduction approach by hardware assist and an operand isolation scheme, which realizes low cost and low power characteristics, respectively.