gebhart/patrepeval huggingface dataset:
Identification and Kinetics of Accumulation of Proteins Induced by Ethylene in Bean Abscission Zones (1992)

A two-dimensional gel electrophoresis system that combines a cationic polyacrylamide gel electrophoresis at pH near neutrality with sodium dodecyl sulfate-polyacrylamide gel electrophoresis was used to analyze the spectrum of basic polypeptides that accumulate in bean (Phaseolus vulgaris) abscission zones after treatment with ethylene. Results showed that, as abscission progressed, at least seven basic proteins accumulated in the abscission zone prior to the accumulation of 9.5 cellulase. Six of the seven proteins correspond to pathogenesis-related (PR) proteins. Among them, two isoforms of beta-1,3-glucanase and multiple isoforms of chitinase were identified. A 22 kilodalton polypeptide that accumulated to high levels was identified as a thaumatin-like protein by analysis of its N-terminal sequence (up to 20 amino acids) and its serological relationship with heterologous thaumatin antibodies. A 15 kilodalton polypeptide serologically related to PR P1 (p14) from tomato was identified as bean PR P1 (p14)-like protein. The kinetics of accumulation of glucanases, chitinases, thaumatin-like and PR P1 (p14)-like proteins during ethylene treatment were similar and they showed that PR proteins accumulated in abscission zones prior to the increase in 9.5 cellulase. Addition of indoleacetic acid, a potent inhibitor of abscission, reduced the accumulation of these proteins to a similar extent (60%). The synchronized accumulation of this set of PR proteins, early in the abscission process, may play a role in induced resistance to possible fungal attack after a plant part is shed. The seventh protein does not correspond to any previously characterized PR protein. This new 45 kilodalton polypeptide accumulated in abscission zones on exposure to ethylene concomitantly with the increase in 9.5 cellulase. Its N-terminal sequence (up to 15 amino acids) showed some homology with the amino terminal sequence of chitinase. Polyclonal antibodies against chitinase recognized the 45 kilodalton polypeptide, but polyclonal antibodies against the 45 kilodalton protein recognized chitinase weakly. When abscission was inhibited by addition of indoleacetic acid, the accumulation of the 45 kilodalton protein was strongly inhibited (80%). This result suggests that the 45 kilodalton polypeptide may play a more direct role in abscission.
The control and evaluation of blue shift in GaInAs/GaInAsP multiple quantum well structures for integrated lasers and Stark-effect modulators (1993)

The authors report on the structural and optical characterization of nominally lattice-matched GaInAs/GaInAsP multiple quantum well (MQW) structures grown on (100) InP substrates by metalorganic chemical vapour deposition (MOCVD) which undergo a 'blue shift' in photoluminescence upon thermal annealing. Electron microscope and magneto-optical analyses show that the shifts are principally due to layer interdiffusion, which results in a change in composition of the well centres. These compositional variations are quantitatively measured by high-resolution analytical electron microscopy. This analysis demonstrates that the diffusion of the group V elements in the undoped MQWS is faster than that of the group III elements, resulting in the incorporation of excess coherency strain in the material. Analysis of a number of samples grown on a variety of substrates shows that the wavelength shift is particularly large when the substrates are S doped, although the substrate dopant does not participate directly in the diffusion mechanism. The authors attribute this behavior to the typically low dislocation density of S-doped substrates. They report, for the first time, a direct measurement of the correlation between the spatial variation in the magnitude of the blue shift and the presence of dislocations in the MQWS.
A 160-MHz analog front-end IC for EPR-IV PRML magnetic storage read channels (1996)

A front-end IC for EPR-IV partial-response maximum likelihood (PRML) detection systems used in magnetic recording systems is developed. Reorganization of the front-end architecture reduces clock acquisition time and lowers chip complexity and power. A new six-pole 80-MHz continuous-time filter equalizes waveforms to the desired ERR-IV target. The equalizer is tuned in quality-factor and frequency to a synthesized system clock, reducing drifts due to processing and temperature variations. An on-chip timing recovery circuit, incorporating a 160-MHz sampled-analog phase detector and 200-MHz voltage-controlled oscillator (VCO) regenerates the data clock. The phase detector used is appropriate for (1, 7) code, and can be extended to operate on (0, k) codes. During head seeks, a secondary loop incorporating the VCO locks to the write clock and acquires the anticipated read-clock frequency. All signal paths are serial and fully differential. The chip is fabricated in a 1-/spl mu/m CMOS process.
The Angelchik antireflux prosthesis: long-term clinical and technical follow-up. (1994)

The second generation of the Angelchik prosthesis, resulted in a reduced rupture rate of the prosthesis. Nevertheless the high complication and the failure rates militate against continued implantation of the prosthesis.
Reality orientation therapy combined with cholinesterase inhibitors in Alzheimer's disease: randomised controlled trial (2005)

Reality orientation enhances the effects of donepezil on cognition in Alzheimer's disease.
Actional-Structural Graph Convolutional Networks for Skeleton-Based Action Recognition (2019)

Action recognition with skeleton data has recently attracted much attention in computer vision. Previous studies are mostly based on fixed skeleton graphs, only capturing local physical dependencies among joints, which may miss implicit joint correlations. To capture richer dependencies, we introduce an encoder-decoder structure, called A-link inference module, to capture action-specific latent dependencies, i.e. actional links, directly from actions. We also extend the existing skeleton graphs to represent higher-order dependencies, i.e. structural links. Combing the two types of links into a generalized skeleton graph, We further propose the actional-structural graph convolution network (AS-GCN), which stacks actional-structural graph convolution and temporal convolution as a basic building block, to learn both spatial and temporal features for action recognition. A future pose prediction head is added in parallel to the recognition head to help capture more detailed action patterns through self-supervision. We validate AS-GCN in action recognition using two skeleton data sets, NTU-RGB+D and Kinetics. The proposed AS-GCN achieves consistently large improvement compared to the state-of-the-art methods. As a side product, AS-GCN also shows promising results for future pose prediction.
Safety and pharmacokinetics of paclitaxel and the oral mTOR inhibitor everolimus in advanced solid tumours (2009)

Everolimus displays antiproliferative effects on cancer cells, yields antiangiogenic activity in established tumours, and shows synergistic activity with paclitaxel in preclinical models. This study assessed the safety and the pharmacokinetic interactions of everolimus and paclitaxel in patients with advanced malignancies. Everolimus was dose escalated from 15 to 30 mg and administered with paclitaxel 80 mg m(-2) on days 1, 8, and 15 every 28 days. Safety was assessed weekly, and dose-limiting toxicity (DLT) was evaluated in cycle 1. A total of 16 patients (median age 54.5 years, range 33-69) were entered; 11 had prior taxane therapy for breast (n=5), ovarian (n=3), and vaginal cancer (n=1) or angiosarcoma (n=2). Grade 3 neutropenia in six patients met the criteria for DLT in two patients receiving everolimus 30 mg weekly. Other drug-related grade 3 toxicities were leucopenia, anaemia, thrombocytopenia, stomatitis, asthenia, and increased liver enzymes. Tumour stabilisation reported in 11 patients exceeded 6 months in 2 patients with breast cancer. Everolimus showed an acceptable safety profile at the dose of 30 mg when combined with weekly paclitaxel 80 mg m(-2), warranting further clinical investigation.
ChemInform Abstract: REACTIONS OF AROMATIC SULPHENYL COMPOUNDS WITH ORGANOTIN COMPOUNDS (1975)

Abstract Die aromatischen Sulfenylhalogenide und ‐thiocyanate (I) reagieren mit den Tributylzinnaromaten (II) in siedendem Dichloräthan unter Spaltung der Aryl‐Zinn‐Bindungen zu den Sulfiden (III) und den Zinnverbindungen (IV).
Postnatal Tissue-specific Disruption of Transcription Factor FoxN1 Triggers Acute Thymic Atrophy (2009)

The transcription factor FoxN1 is essential for differentiation of thymic epithelial cell (TEC) progenitors during thymic organogenesis. However, limited information is available on the postnatal contribution of FoxN1 to thymic maintenance. To address this question, we generated a loxP-floxed FoxN1 (fx) mouse with three different promoter-driven inducible CreER(T) transgenes. Postnatal ubiquitous deletion of FoxN1 caused dramatic thymic atrophy in 5 days and more severe deterioration in medullary TECs (mTECs) than in cortical TECs (cTECs). Induction of FoxN1 deletion selectively in K5 promoter-driven somatic epithelial cells (mostly mTECs and possibly some adult epithelial stem cells) was sufficient to cause significant thymic atrophy, whereas FoxN1 deletion in K18 promoter-driven somatic epithelial cells (mostly cTECs) was not. Thymic atrophy resulted from increased apoptosis and was associated with activation of the p53 gene in mature mTECs. Although FoxN1 is required for the development of both mTECs and cTECs in thymic organogenesis, it is most important for the maintenance of mTECs in the postnatal thymus, which are in turn necessary to prevent thymic atrophy.
Nuclear-heated steam rocket using lunar ice (1997)

A first-order derivation and estimates of the power-permass and specific impulse yield requirements for a nuclear-heated steam rocket (NSR) to deliver payloads to lunar escape from the lunar south pole. The NSR would use lunar-derived water directly as its rocket propellant. Estimates of the ice and cryofuel processing infrastructure masses for the cryofuel alternative provide a reference for comparison. Low Performance, Baseline and High Performance NSR examples calculate payloads delivered and propellant used, given a range of specific power assumptions. Issues of nuclear fuel element temperature and power density are discussed. Results suggest that power density of order 75 megawatts per ton of rocket at a specific impulse of 195 seconds (mixed mean outlet temperature of order 1100 K) are both achievable and will provide highly competitive payloads. For example, a 2 ton, Low Performance NSR tanker making 3 trips per day would deliver of order 240 tons of payload per month to lunar escape. Compared to a cryofueled system, Baseline NSR requires between 150 and 720 times less infrastructure to deliver a given payload to lunar escape. This could imply a dramatic drop in mission cost.
Therapeutic potential of proteasome inhibitors in congenital erythropoietic porphyria (2013)

Congenital erythropoietic porphyria (CEP) is a rare autosomal recessive disorder characterized by uroporphyrinogen III synthase (UROS) deficiency resulting in massive porphyrin accumulation in blood cells, which is responsible for hemolytic anemia and skin photosensitivity. Among the missense mutations actually described up to now in CEP patients, the C73R and the P248Q mutations lead to a profound UROS deficiency and are usually associated with a severe clinical phenotype. We previously demonstrated that the UROS(C73R) mutant protein conserves intrinsic enzymatic activity but triggers premature degradation in cellular systems that could be prevented by proteasome inhibitors. We show evidence that the reduced kinetic stability of the UROS(P248Q) mutant is also responsible for increased protein turnover in human erythroid cells. Through the analysis of EGFP-tagged versions of UROS enzyme, we demonstrate that both UROS(C73R) and UROS(P248Q) are equally destabilized in mammalian cells and targeted to the proteasomal pathway for degradation. We show that a treatment with proteasomal inhibitors, but not with lysosomal inhibitors, could rescue the expression of both EGFP-UROS mutants. Finally, in CEP mice (Uros(P248Q/P248Q)) treated with bortezomib (Velcade), a clinically approved proteasome inhibitor, we observed reduced porphyrin accumulation in circulating RBCs and urine, as well as reversion of skin photosensitivity on bortezomib treatment. These results of medical importance pave the way for pharmacologic treatment of CEP disease by preventing certain enzymatically active UROS mutants from early degradation by using proteasome inhibitors or chemical chaperones.
Nasal Obstruction as a Common Side-Effect of Sildenafil Citrate (2006)

Sildenafil citrate is an effective oral drug for erectile dysfunction. The main action of sildenafil is the enhancement of the effect of nitric oxide (NO) by inhibiting the cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase-5 (PDE-5), an enzyme responsible for degradation of cGMP. NO is also present in the nasal mucosa and is responsible for vasodilation causing congestion and nasal obstruction. The aim of this study was to detect the effect of sildenafil on nasal mucosa in terms of nasal obstruction. A total of 16 patients presented to urology clinic suffering from impotence and medicated with sildenafil were included in the study. Before and after oral administration of 50 mg sildenafil, in all of the patients the nasal patency was examined by active anterior rhinomanometry (a method of assessing nasal resistance) using air pressure of 150 Pascal. In addition, all patients were asked about their sensation of nasal patency to detect the symptomatic nasal obstruction. There was a significant decrease in nasal air flow values (cm(3)/s) (p < 0.05). Except for three cases, all patients indicated that they had the sensation of nasal obstruction after the use of sildenafil (p < 0.05). Nasal obstruction is a common complaint for the patients using Sildenafil.
<b>Ovarian atypical endometriosis: its close association with malignant epithelial tumours</b> (1997)

The incidence of ovarian atypical endometriosis and its association with malignant epithelial tumours in a consecutive series of cases during the period 1987 to 1995 were studied. Atypical glandular changes were observed in four (1.7%) of 255 ovarian endometriosis cases and one patient with ovarian atypical endometriosis developed subsequent endometrioid carcinoma in the abdominal wall. Fifty-four (24.1%) of the 224 ovarian cancers were associated with ovarian endometriosis; 21 with typical and 33 with atypical endometriosis. Clear cell carcinomas and endometrioid carcinomas were most frequently associated with endometriosis, with 54% (27 of 50 cases) and 41.9% (13 of 31), respectively. Atypical endometriosis was found in 18 clear cell carcinomas, in seven endometrioid carcinomas, in four serous carcinomas, in three mucinous borderline tumours, and in one serous borderline tumour. In 13 cases, the atypical endometriosis was in contiguity with malignant epithelial tumours. We consider that atypical endometriosis possesses a precancerous potential or is most frequently associated with clear cell and endometrioid carcinomas. Close screening of cellular atypia or hyperplasia in ovarian endometriosis and careful long-term follow-up of patients with atypical endometriosis is required.
AMA - Vaccination debate: 'No jab, no play' campaign flawed (2013)

Health experts and anti-vaccination lobby groups have slammed the push to prevent non-immunised kids' admission to childcare centres and schools - but for vastly different reasons.
Lacunarity of geophysical well logs in the Cantarell oil field, Gulf of Mexico (2006)

En este trabajo fueron analizadas las variaciones fractales y de lagunaridad de los registros geofísicos de pozo, con el fin de asociarlos con las propiedades estratigráficas y petrofísicas del yacimiento naturalmente fracturado de Cantarell, en el Golfo de México. Los registros considerados fueron: porosidad neutrón (NPHI), densidad (RHOB, DRHO, PEF), resistividad (LLD, LLS, MSFL), radiactividad natural (GR, CGR, URAN, POTA, THOR) y caliper (CALI). Los registros de resistividad produjeron valores de lagunaridad notablemente altos, especialmente en las rocas generadoras y almacenadoras, a diferencia de los demás registros, cuya homogeneidad de traza implicó una baja lagunaridad. Los resultados indican que la lagunaridad observada depende de la resolución y profundidad radial de penetración del método geofísico estudiado y aumenta sistemáticamente en el siguiente orden: (RHOB) < (CALI) < (PEF) < (URAN) < (GR) < (NPHI) < (POTA) < (CGR) < (THOR) < (MSFL) < (DRHO) < (LLS) < (LLD).
<title>"Schottky-Barrier Infrared Charge-Coupled Device Focal Plane Arrays"</title> (1983)

Recent development of high-performance Pd2Si and PtSi Schottky-barrier IR-CCD image sensors make these monolithic focal plane arrays attractive for many SWIR and thermal imaging applications. PtSi Schottky-barrier detectors operated at 80K have quantum efficiency of several percent in the 3 to 5 μm spectral range and cut-off wavelength of about 6.0 μm. Pd2Si Schottky-barrier detectors operated between 120 and 140K have cut-off wavelength of 3.6 μm and quantum efficiency in the range of 1.0 to 8.0% in the SWIR band. High-quality thermal imaging was achieved with a 64x128-element PtSi Schottky-barrier IR-CCD imager in a TV compatible IR camera operated with 60 frames per second. This paper reviews the Schottky-barrier IR-CCD technology developed at RCA. A model for photoyield of Schottky-barrier detectors (SBDs) is reviewed and compared with experimen-tal data. The architecture and design trade-offs of the SBD IR-CCD imagers are discussed. Also included is a discussion of the quantum efficiency requirements for staring thermal imagers and the performance achievable with the Schottky-barrier IR-CCD arrays.
Automatic recognition of speakers from their voices (1976)

This paper presents a survey of automatic speaker recognition techniques. The paper indudes a discussion of the speaker-dependent properties of the speech signal, methods for selecting an efficient set of speech measurements, results of experimental studies illustrating the performance of various methods of speaker recognition, and a comparision of the performance of automatic methods with that of human listeners. Both text-dependent as well as text-independent speaker-recognition techniques are discussed.
ATP‐dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by <i>mdr1</i> P‐glycoprotein (1994)

The ATP-dependent transport of the three 3H-labeled, amphiphilic cations quinidine, N-(n-pentyl)-quinidinium, and N-(4',4'-azo-n-pentyl)-21-deoxyajmalinium was studied in rat canalicular plasma membrane vesicles. N-Alkylation of quinidine with an n-pentyl residue resulted in a permanently charged cationic substrate for ATP-dependent transport which exhibited a 10-fold higher transport rate relative to quinidine. The Km value was 0.4 microM for N-(n-pentyl)-quinidinium and 5 microM for quinidine. The permanently cationic and photolabile derivative of ajmaline, N-(4',4'-azo-n-pentyl)-21-deoxyajmalinium, was also an efficient substrate and served to label canalicular membrane proteins with molecular masses of 143 kDa and 108 kDa. ATP-dependent transport of the permanently charged amphiphilic cations was inhibited by the P-glycoprotein inhibitors and substrates quinidine, verapamil, and daunorubicin. The data demonstrate that N-alkylation of quinidine and ajmaline results in most efficient substrates for mdr1 P-glycoprotein-mediated ATP-dependent transport.
CSF‐adrenaline ‐ low in “somatizing depression” (1987)

Cerebrospinal fluid (CSF) adrenaline and noradrenaline were measured in 14 depressed patients and in seven controls. CSF-adrenaline, but not noradrenaline, was significantly reduced in the depressed patients. Moreover, a significantly negative correlation between "anxiety, somatic", "hypochondriasis", evaluated as single items on the Hamilton Depression Scale, and CSF-adrenaline concentrations, was found.
Hypoglycemia Warning Signal and Glucose Sensors: Requirements and Concepts (2003)

Hypoglycemia is the most feared side effect of diabetes therapy with blood glucose-lowering agents. The fear of hypoglycemia often contributes to poor metabolic control of patients with diabetes. Therefore, integration of a hypoglycemia warning signal into continuous glucose monitoring systems represents an important additional help for patients with diabetes. The warning signal can be triggered at a preset level based on the current glucose values (as provided with the presently available glucose monitoring systems) or on prospective trend analysis offering the possibility to predict the risk of a hypoglycemic event in an anticipatory manner. Using the approach of a "Finite State Machine," such a more advanced warning system can completely be described as a finite collection of four states and possible transitions in-between. Most of the currently available glucose monitoring systems measure glucose in the interstitial fluid (ISF) of the dermal or subcutaneous tissue but are calibrated to blood glucose levels. This requires a number of factors to be taken into account: precision and accuracy of the glucose measurements, physiological and physical lag time, and calibration of the glucose monitoring system. From our point of view, the analytical performance of the system should be such that the majority of all hypoglycemic episodes are correctly diagnosed (>75%). Inconsistent findings regarding physiological discrepancies between blood and ISF glucose, which usually are described as a physiological lag time, range from some seconds up to 15 min. They can be observed especially during dynamic blood glucose changes (>3 mg/dL/min) and may represent major challenges for the development of a reliable hypoglycemia warning signal. In addition to possible physiological time lags, device-inherent physical lag times must be considered when selecting the threshold for the warning signal. Despite these problems, most probably all patients with diabetes who are treated with blood glucose-lowering agents will benefit from such a system since their safety and quality of life can be greatly improved, including an optimized metabolic control and lowered diabetes-related mortality. The benefit will be greatest for patients with hypoglycemia unawareness or impaired perception of hypoglycemic symptoms. The risks related to the use of a hypoglycemia warning signal seem to be low if certain precautionary measures are taken. In any case, additional clinical-experimental studies in healthy subjects as well as long-term clinical studies in diabetic patients are necessary to further evaluate the efficacy, benefits, and risks of different hypoglycemia warning concepts implemented in the different continuous glucose monitoring systems.
The Effectiveness of Dental Floss in Reducing Gingival Inflammation (1979)

Unwaxed and waxed dental floss were clinically evaluated for effectiveness in reducing gingival inflammation. Two different scoring methods were employed. Both types of floss, when administered by a dental hygienist, were very effective, but no significant differences between them could be found. Both scoring methods led to the same conclusions, but one was more sensitive and provided more detailed information.