gebhart/patrepeval huggingface dataset:
Hybrid Rigid-Soft Exoskeleton Design (2018)

This thesis presents a hybrid approach to exoskeleton design, a novel approach of
combining rigid and compliant elements to create capable, wearable devices. An assistive
hand exoskeleton has been designed with this hybrid approach to return the ability
to perform activities of daily living (ADLs) and improve quality of life (QOL) for a broad
population with hand impairment. This compliant, glove-like exoskeleton resides on
the spectrum between traditional rigid devices and the latest soft robotic designs. The
device is underactuated, enabling seven hand poses which support most ADLs. The design
of the softgoods includes novel ergonomic elements for power transmission and
features that ease donning and doffing. Wearable sensors enable pose estimation and
intent detection. The SeptaPose Assistive RoboGlove (SPAR Glove) is a prototype wearable
solution to overcoming hand impairment. In addition to its role as an assistive orthosis,
this exoskeleton has the potential to provide “hands-in” rehabilitation centered
on performing functional tasks. Component-level characterization of the device, such
as the force output, range of motion, and the efficacy of the power transmission, show
that the SPAR Glove exceeds the requirements of ADLs and the capabilities of state-ofthe-
art devices. System-level feedback from users performing simulated ADL suggests
that the SPAR Glove has potential to impact QOL and indicated further directions for
development. The SPAR Glove design can serve in a broad assistive role and as a testbed
for assistive device design, intent detection and user interface research.
3-Alkyl- and 3-Aryl-7H-furo[3, 2-g]-1-benzopyran-7-ones: Synthesis, Photoreactivity, and Fluorescence Properties (2002)

A series of 3-alkyl- and 3-aryl-7H-furo[3, 2-g]-1-benzopyran-7-ones, known as linear furocoumarins, was synthesized and evaluated for their dark- and photobinding (crosslink formation) with DNA as well as for their spectrophotometric and fluorescent properties, lipophilicity, and ability to photobleach N, N-dimethyl-p-nitrosoaniline (RNO) after irradiation with UVA light. 8-Methoxypsoralen (8-MOP, 9-methoxy-7H-furo[3, 2-g]-1-benzopyran-7-one) and 4, 5', 8-trimethylpsoralen (TMP, 2, 5, 9-trimethyl-7H-furo[3, 2-g]-1-benzopyran-7-one) were used as reference compounds in all tests. The investigations support the formation of a molecular complex between the furocoumarins and DNA. Crosslink formation with DNA after irradiation with UVA light was detectable for compounds with a methyl or phenyl substituent in position 3, but not for those bearing either a tert-butyl, a 4-methoxyphenyl, or a 2, 5-dimethoxyphenyl group. All furocoumarins exhibited sufficient absorption in the UVA wavelength range and are fluorescent. All compounds showed a higher lipophilicity than 8-MOP. Generally the 3-alkyl substituted furocoumarins had a capacity to photobleach RNOwhich was higher than that of the 3-aryl substituted ones. Some of the 3-aryl substituted furocoumarins displayed a photobleaching ability which was similar to or lower than that of 8-MOP.
Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties (2015)

Ferroptosis is a nonapoptotic, iron-catalyzed form of regulated necrosis that is critically dependent on glutathione peroxidase 4 (GPX4). It has been shown to contribute to liver and kidney ischemia reperfusion injury in mice. A chemical inhibitor discovered by high-throughput screening displayed inhibition of ferroptosis with nanomolar activity and was dubbed ferrostatin-1 (fer-1). Ferrostatins inhibit oxidative lipid damage, but suffer from inherent stability problems due to the presence of an ester moiety. This limits the application of these molecules in vivo, due to rapid hydrolysis of the ester into the inactive carboxylic acid. Previous studies highlighted the importance of the ethyl ester and suggested steric modifications of the ester for generating improved molecules. In this study, we report the synthesis of novel ferroptosis inhibitors containing amide and sulfonamide moieties with improved stability, single digit nanomolar antiferroptotic activity, and good ADME properties suitable for application in in vivo disease models.
Using multimedia and the Web to teach the theory of digital multimedia signals (2002)

The paper is about using multimedia via the World Wide Web in a course that teaches the theory behind digital audio and video. New course materials accessible via the Web are now used by students to explore demos that were presented in class. At Georgia Tech (and soon Rose-Hulman) a relatively new course that teaches the fundamentals of discrete signal processing (DSP) to sophomores is now required of computer engineering majors. Because DSP is involved in every aspect of multimedia information signals (coding, transmission, storage, playback etc.) the numerous in-class demos and all of the labs relate to the creation or analysis of sounds or images via computer. The course is structured so that the classroom time is used to explain theory, which is then implemented in lab to explore a given concept (e.g., sampling rates) or carry out a small design (e.g., write a MATLAB program to produce a sequence of sinusoidal waveforms that when sent to a speaker will play a song such as Ramblin' Wreck). Traditionally, reading and homework assignments provide a link between lectures and labs. In this course the lecture/lab gap is closed via follow-up demos that are run by the students via the Web. Labs are assigned that require the students to run demos that illustrate and reinforce concepts introduced in the lecture. The homework assignments are designed to help the students to make the transition from the overview/demo mode to the implementation/lab mode. This leads them to implement something via MATLAB to test their answer.
The adsorbed conformation of globular proteins at the air/water interface (2006)

External reflection FTIR spectroscopy and surface pressure measurements were used to compare conformational changes in the adsorbed structures of three globular proteins at the air/water interface. Of the three proteins studied, lysozyme, bovine serum albumin and beta-lactoglobulin, lysozyme was unique in its behaviour. Lysozyme adsorption was slow, taking approximately 2.5 h to reach a surface pressure plateau (from a 0.07 mM solution), and led to significant structural change. The FTIR spectra revealed that lysozyme formed a highly networked adsorbed layer of unfolded protein with high antiparallel beta-sheet content and that these changes occurred rapidly (within 10 min). This non-native secondary structure is analogous to that of a 3D heat-set protein gel, suggesting that the adsorbed protein formed a highly networked interfacial layer. Albumin and beta-lactoglobulin adsorbed rapidly (reaching a plateau within 10 min) and with little change to their native secondary structure.
Effects of Aggregate Size on Properties of Concrete (1960)

First Name is required invalid characters Last Name is required invalid characters Email Address is required Invalid Email Address Invalid Email Address
Colchicine for Prevention of Postpericardiotomy Syndrome and Postoperative Atrial Fibrillation (2014)

clinicaltrials.gov Identifier: NCT01552187.
Survey on Advances in Magnetic Induction-Based Wireless Underground Sensor Networks (2018)

Underground communication systems present a variety of new research challenges. Here, the goal is to establish an efficient wireless connection between the transceivers in the challenging underground medium. Typical applications for this type of communication systems include soil condition monitoring, earthquake prediction, communication in mines/tunnels, etc. These applications require a gathering of relevant information from multiple locations, which suggests the use of multiple sensor nodes that would be organized in wireless underground sensor networks (WUSNs). Due to the harsh propagation conditions in the soil medium (including rock, sand, and water sheds), traditional wireless signal propagation techniques using electromagnetic waves can only be applied for very short transmission ranges. In recent years, magnetic induction (MI)-based transmission has been proposed to overcome these issues. In this approach, induction coils are utilized as antennas in the transceivers in order to reduce the vulnerability of signal propagation to the soil properties, in particular the soil conductivity. Correspondingly, the design rules for optimum MI-WUSNs have been shown to substantially differ from the design rules for the traditional wireless communication systems due to unique properties of the transmission channel. In this survey paper, the recent advances in the area of MI-WUSNs are discussed, which range from signal transmission techniques and network design to wireless power transfer and localization. Also, new research challenges in this area are provided.
[Multidrug resistance protein (MRP)]. (1997)

Two different integral glycoproteins, the 170 kD P-glycoprotein(P-gp) and the 190 kD multidrug resistance protein (MRP), are involved in the acquisition of multidrug resistance phenotypes in cancer cells. These two proteins belong to the ATP-binding cassette (ABC) superfamily but their primary structures are quite dissimilar, sharing only approximately 15% amino acid identity. Nevertheless, MRP and P-gp confer resistance to a similar profile of chemotherapeutic agents. These two proteins seem to play a similar role in the acquirement of multidrug resistance. However, it has recently been demonstrated that MRP can specifically transport the cysteinyl leukotriene, LTC4, and some other glutathione conjugates, suggesting that MRP had a function different from P-gp. This review summarizes the current data on the structural and functional characteristics of MRP, its ability to confer multidrug resistance and its clinical relevance in drug resistant malignant disease.
Evaluation of polyacrylamides for reducing water production (1976)

This investigation of polyacrylamides focuses on determining which properties are most important for reducing the permeability to water and how these properties relate to the success of treatments in the field. The tests show that shear degradation of polyacrylamides does not necessarily reduce their effectiveness. Compatibility of the polyacrylamide solution with both the formation matrix and the formation water is important, and best results are expected in wells where water and oil are being produced from different layers. Oil production may be restricted by injudicious use of cross-linking agents, undissolved polyacrylamide, extremely high concentrations of polymer, or by treating sandstones that have high clay contents.
Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels. (1994)

Results from in vitro experiments suggest that development of nitrate tolerance is due to a depletion of vascular thiol compounds (ie, cysteine and glutathione [GSH]) necessary for the bioconversion of organic nitrates. However, it is unknown whether in vivo tolerance development is associated with changes in thiol levels. This study measures plasma and vessel tissue GSH and cysteine levels in nontolerant rats, nitrate-tolerant rats, and rats treated with the two characteristically different thiol donors N-acetyl-L-cysteine and L-2-oxothiazolidine-4-carboxylic acid (OXO). Chronically catheterized conscious rats received an intravenous infusion of either nitroglycerin (NTG, 0.2 mg/h) or matching placebo for 3 days. At day 3, the hypotensive effect of 2.5 mg NTG/kg was decreased by 74 +/- 6% (mean +/- SEM, P < .05) in the NTG-treated group (n = 7), indicating the development of tolerance. No change in the hypotensive effect of NTG was seen in the placebo group (n = 6, P > .05). Hemodynamic tolerance is not associated with changes in aorta cysteine or GSH levels as compared with the placebo group (cysteine, 77 +/- 14 versus 57 +/- 11 [mean + SEM] nmol/g; GSH, 414 +/- 62 versus 399 +/- 89 nmol/g; P > .05). However, the increase in vascular thiol levels seen after OXO treatment in nontolerant rats is completely absent in nitrate-tolerant animals.(ABSTRACT TRUNCATED AT 250 WORDS)
A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine-related hypotension after cardiopulmonary bypass (2005)

Increased bradykinin contributes to protamine-related hypotension through its B(2) receptor in ACE inhibitor-treated patients.
Global cerebral vasodilation by stimulation of rat fastigial cerebellar nucleus (1982)

The effects of electrical stimulation of the pressor area of the fastigial nucleus (FN) of cerebellum on regional cerebral blood flow (CBF) were examined in anesthetized, paralyzed rats. CBF was measured in tissue homogenates by the Kety principle using 14C-iodoantipyrine as an indicator during FN stimulation, during stimulation of the vermal cortex, or after placement of electrodes in FN (unstimulated controls). Blood gases and systemic arterial pressures were comparable in the three groups. FN stimulation elicited a widespread and significant (P less than 0.005) increase in CBF in 12 of 13 areas. Flow was maximally increased in cerebral cortex (up to 220% of control) but also rose in selected regions of telencephalon, diencephalon, mesencephalon, lower brain stem, and in white matter of the corpus callosum (172%). Flow was not increased in cerebellum. The increase in CBF persisted after transection of the spinal cord at C1 or cervical sympathectomy. In five rats, hypercarbia (PCO2 to 63 mmHg) increased CBF in all 13 regions but in a pattern differing from FN stimulation. Excitation of neurons originating in, projecting to, or passing through FN can elicit a potent and virtually global increase of CBF. The effect appears mediated by intrinsic pathways of the central nervous system.
Intelligent conflict detection and awareness for UAVs (2009)

The deployment of unmanned aerial vehicles into the airspace is directly related to their ability to detect and avoid other aircraft objects. Through the performance analysis of the conflict detection and avoidance requirement, conceptual functional architecture of the conflict detection and conflict awareness are proposed with a method to extract collision parameters. These parameters include collision points, time to collision, collision interval and collision angle. The method is based onto monitoring the environment and sharing of flight plan segments among conflicting aircraft. The detection of a potential conflict is achieved by projecting states of the conflicting aircrafts' flight plans in the near future. In addition, the method estimates a suitable time to activate avoidance model and pass extracted collision parameters to that model. That is, in order to handle the maneuvering commands and thereby avoid conflicts.
Phase III Trial of Fluorouracil, Interferon Alfa-2b, and Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Metastatic or Unresectable Urothelial Cancer (2002)

PURPOSE: Previously, we developed a novel biochemotherapy regimen combining interferon alfa-2b with fluorouracil and cisplatin (FAP). We now report the results of a prospective randomized trial comparing FAP with methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC), the standard chemotherapy regimen for locally advanced and metastatic urothelial cancer. The purpose of this study was to compare the response rates and overall survival of patients with metastatic or unresectable urothelial cancer treated with these two chemotherapy regimens. PATIENTS AND METHODS: Between October 1992 and September 1999, 172 previously untreated patients were registered and randomly assigned to treatment with either FAP or M-VAC. Patients were followed until their death. RESULTS: The pretreatment clinical characteristics of the groups were similar except for sex (P < .01). Sex did not affect prognosis or survival. The objective response rate for patients assigned to FAP was 42% (35 of 83 patients), with complete response observed in eight (10%) of 83 patients. Among the patients assigned to M-VAC, 51 (59%) of 86 had an objective response, with complete response observed in 21 (24%) of 86. The Kaplan-Meier estimate of median survival was 12.5 months for both groups. Both regimens were quite toxic, with more mucocutaneous toxicity in the FAP arm and more myelosuppression in the M-VAC arm. CONCLUSION: Although overall survival was not significantly different, patients assigned to M-VAC had a much better chance of responding to front-line therapy. Thus, FAP is very likely to be inferior to M-VAC and is certainly no less toxic. FAP cannot be recommended as part of the standard armamentarium for urothelial cancer.
Force-directed scheduling for Data Flow Graph mapping on Coarse-Grained Reconfigurable Architectures (2014)

In terms of energy and flexibility, Coarse-Grained Reconfigurable Architectures (CGRA) are proven to be advantageous over fine-grained architectures, massively parallel GPUs and generic CPUs. However the key challenge of programmability is preventing wide-spread adoption. To exploit instruction level parallelism inherent to such architectures, optimal scheduling and mapping of algorithmic kernels is essential. Transforming an input algorithm in the form of a Data Flow Graph (DFG) into a CGRA schedule and mapping configuration is very challenging, due the necessity to consider architectural details such as memory bandwidth requirements, communication patterns, pipelining and heterogeneity to optimally extract maximum performance. In this paper, an algorithm is proposed that employs Force-Directed Scheduling concepts to solve such scheduling and resource minimization problems. Our heuristic extensions are flexible enough for generic heterogeneous CGRAs, allowing to estimate the execution time of an algorithm with different configurations, while maximizing the utilization of available hardware. Beside our experiments, we compare also given CGRA configurations introduced by state-of-the-art mapping algorithms such as EPIMap, achieving optimal resource utilization by our schedule with a reduced overall DFG execution time by 39% on average.
An alternative topical treatment of osteoarthritis of the knee with cutaneous diclofenac solution (2008)

The clinical studies showed that applying the topical diclofenac solution (Pennsaid) to a painful knee with primary OA could provide symptom relief equivalent to oral diclofenac with minimal systemic side effects; however, studies are needed that compare the effectiveness of Pennsaid with different topical forms of diclofenac.
Mathematical models of metabolic systems: general principles and control of glycolysis and membrane transport in erythrocytes. (1985)

General methods for the mathematical modeling of metabolic systems are discussed. Attention is paid to the simulation of steady states as well as time dependent behaviour of biochemical reaction networks. Control coefficients are used for the quantitative evaluation of the parameter dependence of model variables. The methods are applied to the mathematical analysis of the energy metabolism of erythrocytes. New results are presented concerning the interaction of glycolysis and osmotic behaviour of the red cell (metabolic-osmotic model). A general method for the calculation of control coefficients is developed which gives the basis also for the interpretation of control coefficients using chains of causal actions.
A recommendation model for personalized book lists (2010)

In this study, we present a novel approach to recommend the personalized book lists for the university members. Our approach consists of clustering the university members into different clusters based on their recent circulation activities and discovering the interest patterns of members in the cluster. In the first step, we clustered members sharing the common interests to the same cluster by using K-means algorithm, after that we explored the possible interest patterns performed by members in each cluster by association rules. Finally, we provided the recommended book lists that satisfy their individual needs and interest patterns. A questionnaire survey was performed to evaluate the accuracy satisfaction of predicting the satisfy book list to an individual. The evaluation results reveal the possibility of using circulation activity history to predict the current interest of an individual member and construct the personalized book lists that satisfy their interests.
Probucol therapy in the prevention of restenosis after successful percutaneous transluminal coronary angioplasty. (1993)

The effect of probucol, a drug that inhibits the secretion of smooth muscle cell-derived growth factor, was evaluated in the prevention of restenosis after percutaneous transluminal coronary angioplasty (PTCA). In 67 patients who successfully underwent prospective PTCA for the first time, the effects obtained in 31 patients given 750 mg or 1000 mg of probucol daily (group P) were compared with those in 36 patients given 150 mg of dipyridamole daily (group D). Drug treatment was initiated at least 7 days before PTCA and was continued for 3 to 6 months after PTCA, at which time a follow-up angiography was performed. There were no significant differences in patient characteristics (age, sex, pre-PTCA severity of angina pectoris), the number of affected vessels undergoing dilatation, or the residual degree of stenosis. The restenosis rate was significantly lower in group P (6 cases, 19.4%) than in group D (15 cases, 41.7%). In the nonrestenosis subgroup, the degree of stenosis progressed from 28.0 +/- 13.9% just after PTCA to 32.4 +/- 20.5% at follow-up angiography in group P, while it progressed significantly from 28.6 +/- 15.6% to 40.1 +/- 21.2% in group D (P < 0.05). A significant drop in serum cholesterol was observed in group P. The restenosis rate was lower in patients with high cholesterol levels at PTCA. No adverse reactions were noted in any patient. We conclude that probucol is effective in preventing restenosis after PTCA.
Enhanced antiinflammatory capacity of a <i>Lactobacillus plantarum</i> mutant synthesizing modified teichoic acids (2005)

Teichoic acids (TAs), and especially lipoteichoic acids (LTAs), are one of the main immunostimulatory components of pathogenic Gram-positive bacteria. Their contribution to the immunomodulatory properties of commensal bacteria and especially of lactic acid bacteria has not yet been investigated in detail. To evaluate the role of TAs in the interaction between lactic acid bacteria and the immune system, we analyzed the antiinflammatory properties of a mutant of Lactobacillus plantarum NCIMB8826 affected in the TA biosynthesis pathway both in vitro (mononuclear cells stimulation) and in vivo (murine model of colitis). This Dlt- mutant was found to incorporate much less D-Ala in its TAs than the WT strain. This defect significantly impacted the immunomodulation reactions induced by the bacterium, as shown by a dramatically reduced secretion of proinflammatory cytokines by peripheral blood mononuclear cells and monocytes stimulated by the Dlt- mutant as compared with the parental strain. Concomitantly, a significant increase in IL-10 production was stimulated by the Dlt- mutant in comparison with the WT strain. Moreover, the proinflammatory capacity of L. plantarum-purified LTA was found to be Toll-like receptor 2-dependent. Consistent with the in vitro results, the Dlt- mutant was significantly more protective in a murine colitis model than its WT counterpart. The results indicated that composition of LTA within the whole-cell context of L. plantarum can modulate proinflammatory or antiinflammatory immune responses.