gebhart/patrepeval huggingface dataset:
Bandwidth optimization of optical data links by use of error-control codes (2000)

A design approach to optimizing the bandwidth of optical data links while simultaneously decreasing the bit-error rate is proposed. Mathematical analysis indicates that bandwidth gains by factors of 10-60 with power gains of as much as 8.9 dB are possible. To achieve these performance levels requires several innovations. First, conventional forward error-correcting codes cannot be used because of their excessive hardware cost. A reasonably powerful multidimensional parity-based error-control code is proposed and analyzed. These codes offer excellent error detection and moderate error-correction capabilities. Most importantly, they can operate at the fast clock rates that are required. Second, a hybrid automatic-repeat-request protocol is exploited to correct complex error patterns. In thermal-noise-limited systems this unique combination allows the optical clock rate to be increased significantly, thereby resulting in large bandwidth increases. The proposed design approach can be used in optical data links in which propagation delays are moderate and is applicable to fibers that exploit wavelength-division multiplexing or time-division multiplexing, one-dimensional parallel-fiber ribbons, and two-dimensional optical data links that use free space or guided waves. Several design examples are illustrated.
Tulane virus recognizes sialic acids as cellular receptors (2015)

The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell culture model. In this study, we demonstrated that Tulane virus (TV), a cultivable primate calicivirus, also recognizes SAs in addition to the previously known TV-HBGA interactions. Evidence supporting this discovery includes that TV virions bound synthetic sialoglycoconjugates (SGCs) and that treatment of TV permissive LLC-MK2 cells with either neuraminidases or SA-binding lectins inhibited TV infectivity. In addition, we found that Maackia amurensis leukoagglutinin (MAL), a lectin that recognizes the α-2,3 linked SAs, bound LLC-MK2 cells, as well as TV, by which MAL promoted TV infectivity in cell culture. Our findings further highlight TV as a valuable surrogate for huNoVs, particularly in studying virus-host interactions that may involve two host carbohydrate receptors or co-receptors for infection.
Phosphodiesterase‐1b deletion confers depression‐like behavioral resistance separate from stress‐related effects in mice (2017)

Phosphodiesterase-1b (Pde1b) is highly expressed in striatum, dentate gyrus, CA3 and substantia nigra. In a new Floxed Pde1b × Cre<sup>CMV</sup> global knockout (KO) mouse model, we show an immobility-resistance phenotype that recapitulates that found in constitutive Pde1b KO mice. We use this new mouse model to show that the resistance to acute stress-induced depression-like phenotype is not the product of changes in locomotor activity or reactivity to other stressors (learned helplessness, novelty suppressed feeding or dexamethasone suppression), and is not associated with anhedonia using the sucrose preference test. Using tamoxifen inducible Cre, we show that the immobility-resistant phenotype depends on the age of induction. The effect is present when Pde1b is Reduced from conception, P0 or P32, but not if reduced as adults (P60). We also mapped regional brain expression of PDE1B protein and of the Cre driver. These data add to the suggestion that PDE1B may be a target for drug development with therapeutic potential in depression alone or in combination with existing antidepressants.
Cell-surface Heparan Sulfate Proteoglycans Potentiate Chordin Antagonism of Bone Morphogenetic Protein Signaling and Are Necessary for Cellular Uptake of Chordin (2004)

Signaling by bone morphogenetic proteins (BMPs) plays a central role in early embryonic patterning, organogenesis, and homeostasis in a broad range of species. Chordin, an extracellular antagonist of BMP signaling, is thought to readily diffuse in tissues, thus forming gradients of BMP inhibition that result in reciprocal gradients of BMP signaling. The latter determine cell fates along the embryonic dorsoventral axis. The secreted protein Twisted Gastrulation (TSG) is thought to help shape BMP signaling gradients by acting as a cofactor that enhances Chordin inhibition of BMP signaling. Here, we demonstrate that mammalian Chordin binds heparin with an affinity similar to that of factors known to functionally interact with heparan sulfate proteoglycans (HSPGs) in tissues. We further demonstrate that Chordin binding in mouse embryonic tissues was dependent upon its interaction with cell-surface HSPGs and that Chordin bound to cell-surface HSPGs (e.g. syndecans), but not to basement membranes containing the HSPG perlecan. Surprisingly, mammalian TSG did not bind heparin unless prebound to Chordin and/or BMP-4, although Drosophila TSG has been reported to bind heparin on its own. Results are also presented that indicate that Chordin-HSPG interactions strongly potentiate the antagonism of BMP signaling by Chordin and are necessary for the retention and uptake of Chordin by cells. These data and others regarding Chordin diffusion have implications for the paradigm of how Chordin is thought to regulate BMP signaling in the extracellular space and how gradients of BMP signaling are formed.
Using Response Models to Estimate Channel Capacity for Neuronal Classification of Stationary Visual Stimuli Using Temporal Coding (1999)

Both spike count and temporal modulation are known to carry information about which of a set of stimuli elicited a response; but how much information temporal modulation adds remains a subject of debate. This question usually is addressed by examining the results of a particular experiment that depend on the specific stimuli used. Developing a response model allows us to ask how much more information is carried by the best use of response strength and temporal modulation together (that is, the channel capacity using a code incorporating both) than by the best use of spike count alone (the channel capacity using the spike count code). This replaces dependence on a particular data set with dependence on the accuracy of the model. The model is constructed by finding statistical rules obeyed by all the observed responses and assuming that responses to stimuli not presented in our experiments obey the same rules. We assume that all responses within the observed dynamic range, even if not elicited by a stimulus in our experiment, could be elicited by some stimulus. The model used here is based on principal component analysis and includes both response strength and a coarse (+/-10 ms) representation of temporal modulation. Temporal modulation at finer time scales carries little information about the identity of stationary visual stimuli (although it may carry information about stimulus motion or change), and we present evidence that, given its variability, it should not be expected to do so. The model makes use of a linear relation between the logarithms of mean and variance of responses, similar to the widely seen relation between mean and variance of spike count. Responses are modeled using truncated Gaussian distributions. The amount of stimulus-related information carried by spike count in our data are 0.35 and 0.31 bits in primary visual and inferior temporal cortices, respectively, rising to 0.52 and 0.37 bits for the two-principal-component code. The response model estimates that the channel capacity is 1.1 and 1.4 bits, respectively, using the spike count only, rising to 2.0 and 2.2 bits using two principal components. Thus using this representation of temporal modulation is nearly equivalent to adding a second independent cell using the spike count code. This is much more than estimated using transmitted information but far less than would be expected if all degrees of freedom provided by the individual spike times carried independent information.
Communication optimizations for parallel C programs (1998)

This paper presents algorithms for reducing the communication overhead for parallel C programs that use dynamically-allocated data structures. The framework consists of an analysis phase called possible-placement analysis , and a transformation phase called communication selection .The fundamental idea of possible-placement analysis is to find all possible points for insertion of remote memory operations. Remote reads are propagated upwards, whereas remote writes are propagated downwards. Based on the results of the possible-placement analysis, the communication selection transformation selects the "best" place for inserting the communication, and determines if pipelining or blocking of communication should be performed.The framework has been implemented in the EARTH-McCAT optimizing/parallelizing C compiler, and experimental results are presented for five pointer-intensive benchmarks running on the EARTH-MANNA distributed-memory parallel architecture. These experiments show that the communication optimization can provide performance improvements of up to 16% over the unoptimized benchmarks.
High-Frequency Resonator Using A<sub>1</sub> Lamb Wave Mode in LiTaO<sub>3</sub> Plate (2019)

Acoustic wave devices utilizing plate waves in thin lithium tantalate (LiTaO<sub>3</sub>) have the potential of achieving high resonance frequency with a suitable electromechanical coupling factor and a relatively small temperature coefficient of frequency (TCF). The influence of Euler angle and plate thickness on the characteristics of plate waves has been investigated. High-frequency resonators using first antisymmetric Lamb wave mode (A<sub>1</sub>) in (0°, 42°, 0°) LiTaO<sub>3</sub> thin plates have been fabricated and optimized. The resonance frequency is as high as 5 GHz, with a relative bandwidth of 7.3% and an impedance ratio of 72 dB. Finally, the TCF of (0°, 42°, 0°) LiTaO<sub>3</sub> has been evaluated. Therefore, it is proved that A<sub>1</sub> Lamb wave mode propagating in LiTaO<sub>3</sub> at a Euler angle close to (0°, 42°, 0°) is suitable for high-frequency devices.
Ultrabroadband terahertz spectroscopy of a liquid crystal (2012)

Liquid crystals (LCs) are becoming increasingly important for applications in the terahertz frequency range. A detailed understanding of the spectroscopic parameters of these materials over a broad frequency range is crucial in order to design customized LC mixtures for improved performance. We present the frequency dependent index of refraction and the absorption coefficients of the nematic liquid crystal 5CB over a frequency range from 0.3 THz to 15 THz using a dispersion-free THz time-domain spectrometer system based on two-color plasma generation and air biased coherent detection (ABCD). We show that the spectra are dominated by multiple strong spectral features mainly at frequencies above 4 THz, originating from intramolecular vibrational modes of the weakly LC molecules.
Analysis of a Miniature Radio Frequency Ion Thruster with an Inductively Coupled Plasma Source (2013)

The performance of a 2 cm miniature ion thruster was analyzed. A thruster of this size was predicted to produce a thrust of 200 μN. The plasma density was measured against rf input power and propellant flow rate for three configurations: the ICP source by itself; the ICP source with discharge chamber; and finally, the ICP source, the discharge chamber, and the permanent magnet cusp system. Once the optimum case was determined, electrostatic grids were added and thrust measurements were taken with a set of segmented ion collector plates. The miniature rf ion thruster obtained a thrust of 22.35 μN and a specific impulse of 15.31 s at its optimum operating condition of 5W of rf power and and propellant flow rate of 5 sccm. With a beam divergence angle of 26.25 degrees and the assumption of a singly charged ion species, the total thrust correction factor was 0.90. The mass utilization efficiency of the thruster was calculated to be 0.24%. The electrical efficiency of thruster was calculated to be 16.94% with an electron-ion energy pair cost of 5.9 keV/ion. The total efficiency of the thruster was 0.033%, a factor of 1000 too low for practical use.
ChemInform Abstract: Studies Directed Toward the Synthesis of Ulapualide A. Asymmetric Synthesis of the C26‐C42 Fragment. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems (2016)

Alpha subunits of heterotrimeric G proteins (Gα) are involved in a variety of cellular functions. Here we report an optogenetic strategy to spatially and temporally manipulate Gα in living cells. More specifically, we applied the blue light-induced dimerization system, known as the Magnet system, and an alternative red light-induced dimerization system consisting of Arabidopsis thaliana phytochrome B (PhyB) and phytochrome-interacting factor 6 (PIF6) to optically control the activation of two different classes of Gα (Gα<sub>q</sub> and Gα<sub>s</sub>). By utilizing this strategy, we demonstrate successful regulation of Ca<sup>2+</sup> and cAMP using light in mammalian cells. The present strategy is generally applicable to different kinds of Gα and could contribute to expanding possibilities of spatiotemporal regulation of Gα in mammalian cells.
T cells discriminate between differentially phosphorylated forms of alphaB-crystallin, a major central nervous system myelin antigen (1998)

Factors such as developmental stage or physiological and infectious stress may change patterns of post-translational protein modification. In order to determine whether such regulated types of modification may influence T cell responsiveness to self proteins we examined the T cell response of SJL (H-2s) mice to alphaB-crystallin, a small heat shock protein that can exist in differentially phosphorylated forms. Epitope mapping revealed the presence of two T cell epitopes that are presented by I-As. One major epitope including residues 41-56 contains an amino acid residue (Ser45) that can be phosphorylated as the result of aging or stress. Accordingly, T cells from SJL mice discriminate between preparations of alphaB-crystallin that differ in their extent of phosphorylation at the level of whole protein as well as at the level of determinant-specific responses. Phosphorylation at Ser45 does not prevent binding of the peptide 41-56 to I-As and computer-assisted modelling of the peptide-MHC complex suggests that the phosphate group of the bound peptide extends outwards from the peptide-binding cleft and may thus be available for direct contact with TCR. Together, our data provide evidence that stress-inducible phosphorylation of alphaB-crystallin creates neo-determinants for T cells and, therefore, may contribute to the breakdown of peripheral tolerance to this self protein.
Molecular cloning and sequence determination of the nuclear gene coding for mitochondrial elongation factor Tu of Saccharomyces cerevisiae. (1983)

A 3.1-kilobase Bgl II fragment of Saccharomyces cerevisiae carrying the nuclear gene encoding the mitochondrial polypeptide chain elongation factor (EF) Tu has been cloned on pBR327 to yield a chimeric plasmid pYYB. The identification of the gene designated as tufM was based on the cross-hybridization with the Escherichia coli tufB gene, under low stringency conditions. The complete nucleotide sequence of the yeast tufM gene was established together with its 5'- and 3'-flanking regions. The sequence contained 1,311 nucleotides coding for a protein of 437 amino acids with a calculated Mr of 47,980. The nucleotide sequence and the deduced amino acid sequence of tufM were 60% and 66% homologous, respectively, to the corresponding sequences of E. coli tufA, when aligned to obtain the maximal homology. Plasmid YRpYB was then constructed by cloning the 2.5-kilobase EcoRI fragment of pYYB carrying tufM into a yeast cloning vector YRp-7. A mRNA hybridizable with tufM was isolated from the total mRNA of S. cerevisiae D13-1A transformed with YRpYB and translated in the reticulocyte lysate. The mRNA could direct the synthesis of a protein with Mr 48,000, which was immunoprecipitated with an anti-E. coli EF-Tu antibody but not with an antibody against yeast cytoplasmic EF-1 alpha. The results indicate that the tufM gene is a nuclear gene coding for the yeast mitochondrial EF-Tu.
Image segmentation by data driven Markov chain Monte Carlo (2002)

This paper presents a computational paradigm called Data Driven Markov Chain Monte Carlo (DDMCMC) for image segmentation in the Bayesian, statistical framework. The paper contributes to image segmentation in three aspects. Firstly, it designs effective and well balanced Markov Chain dynamics to explore the solution space and makes the split and merge process reversible at a middle level vision formulation. Thus it achieves globally optimal solution independent of initial segmentations. Secondly, instead of computing a single maximum a posteriori solution, it proposes a mathematical principle for computing multiple distinct solutions to incorporates intrinsic ambiguities in image segmentation. A k-adventurers algorithm is proposed for extracting distinct multiple solutions from the Markov chain sequence. Thirdly, it utilizes data-driven (bottom-up) techniques, such as clustering and edge detection, to compute importance proposal probabilities, which effectively drive the Markov chain dynamics and achieve tremendous speedup in comparison to traditional jump-diffusion method. Thus DDM-CMC paradigm provides a unifying framework where the role of existing segmentation algorithms, such as; edge detection, clustering, region growing, split-merge, SNAKEs, region competition, are revealed as either realizing Markov chain dynamics or computing importance proposal probabilities. We report some results on color and grey level image segmentation in this paper and refer to a detailed report and a web site for extensive discussion.
Metal-Supported Solid Oxide Fuel Cells (2008)

Abstract not Available.
Photoinduced Dynamics of TiO<sub>2</sub> Doped with Cr and Sb (2008)

Rutile particles doped by Cr and Sb with Sb/Cr ratios greater than unity were active for photocatalytic O2 evolution from an aqueous silver nitrate solution under visible light irradiation. Two vibrational bands appeared in Raman scattering resonant to the electronic absorption and were assigned to symmetric breathing modes of the CrO6 octahedron and neighboring TiO6 octahedra, on the assumption that Cr dopant atoms exactly replaced Ti cations in rutile. Electrons excited with 355-nm and 532-nm light pulses showed absorption of mid-IR light, which was traced as a function of the time delay in a microsecond domain. By optimizing the Sb/Cr ratio, electron−hole recombination was retarded compared with that in non-doped rutile. Chromium dopants when accompanied with antimony dopants are proposed to trap the charge carriers without much enhancement of the recombination. The optimized Sb/Cr ratios were common for both the visible light-induced O2 production and the retarded recombination, suggesting that the charge carriers of the retarded recombination are used to produce O2.
The Relationship Between In-Play Betting and Gambling Problems in an Australian Context of Prohibited Online In-Play Betting (2020)

Internationally, Internet gambling is increasingly permitted under regulated licensing conditions; however, the specific products that are legal varies between jurisdictions. Online sports and race wagering are now legal in many jurisdictions, but in-play betting (also referred to as "live action" or "in-the-run" betting) is often restricted. In-play betting enables bets to be placed on an event after it has commenced. Prohibitionist policies often cite the potential for this type of betting to increase risk of gambling problems. This study aimed to identify which online bettors are most likely to engage in in-play betting, and to investigate the relationship between in-play betting and gambling problems. Online survey responses were collected from 501 Australian past-month online sports bettors in the context of in-play betting only being available on offshore gambling sites or via telephone betting. Thirty-four percent of participants had placed a bet in-play in the past month. Participants placing in-play bets differed from those who had not in terms of education, employment status, ethnicity, age, and gambling involvement. Those who bet in-play had higher problem gambling severity scores than those who did not bet in-play. Problem gambling severity significantly predicting in-play betting, holding other variables constant. Findings are consistent with previous research indicating that the relationship between in-play gambling and problems holds across jurisdictions which have prohibited and legalized in-play betting. The findings suggest that in-play betting should warrant specific regulatory attention and interventions to minimize gambling harms among individuals that engage with this activity.
Reoxidized nitric oxide (ReoxNO) process and its effect on the dielectric reliability of the LOCOS edge (2002)

Reoxidation of an oxynitride gate dielectric grown by NO anneal of thermal oxide has been studied for the first time. This process results in a striking enhancement of both gate and substrate injection Q/sub BD/ by /spl sim/3-5X for active edge intensive capacitors in comparison to thermal oxide, N/sub 2/O and NO oxynitride. This improvement is attributed to reduction of mechanical stress at the active edge which leads to less local thinning of gate oxide at the field oxide edge and reduction of the local build-up of positive charge near the gate electrode at the isolation edges. Drive current of n- and p-MOSFETs with ReoxNO oxynitride is also compared to other dielectrics.
Synergistic Gene Interactions Control the Induction of the Mitochondrial Uncoupling Protein (Ucp1) Gene in White Fat Tissue (2000)

Among a selected group of mouse strains susceptible to dietary obesity, those with an enhanced capacity for Ucp1 and brown adipocyte induction in white fat preferentially lost body weight following adrenergic stimulation. Based on the generality of this mechanism for reducing obesity, a genetic analysis was initiated to identify genes that control brown adipocyte induction in white fat depots in mice. Quantitative trait locus (QTL) analysis was performed using the variations of retroperitoneal fat Ucp1 mRNA expression in progeny of genetic crosses between the A/J and C57BL/6J parental strains and selected AXB recombinant inbred strains. Three A/J-derived loci on chromosomes 2, 3, and 8 and one C57BL/6J locus on chromosome 19 were linked to Ucp1 induction in retroperitoneal fat. Although A/J-derived alleles seemed to contribute to elevated Ucp1 expression, the C57BL/6J allele on chromosome 19 increased Ucp1 mRNA to levels higher than parental values. Thus, novel patterns of C57BL/6J and A/J recombinant genotypes among the four mapped loci resulted in a transgressive variation of Ucp1 phenotypes. Although the extent of the interchromosomal interactions have not been fully explored, strong synergistic interactions occur between a C57BL/6J allele on chromosome 19 and an A/J allele on chromosome 8. In addition to selective synergistic interactions between loci, variations in recessive and dominant effects also contribute to the final levels of Ucp1 expression.