gebhart/patrepeval huggingface dataset:
Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies (2017)

Thymoquinone (TQ), the main bioactive component of Nigella sativa, has been found to exhibit anticancer effects in numerous preclinical studies. Due to its multitargeting nature, TQ interferes in a wide range of tumorigenic processes and counteracts carcinogenesis, malignant growth, invasion, migration, and angiogenesis. Moreover, TQ can specifically sensitize tumor cells toward conventional cancer treatments (e.g., radiotherapy, chemotherapy, and immunotherapy) and simultaneously minimize therapy-associated toxic effects in normal cells. In this review, we summarized the adjuvant potential of TQ as observed in various <i>in vitro</i> and <i>in vivo</i> animal models and discussed the pharmacological properties of TQ to rationalize its supplementary role in potentiating the efficacy of standard therapeutic modalities namely surgery, radiotherapy, chemotherapy, and immunotherapy. Altogether, we suggest further comprehensive evaluation of TQ in preclinical and clinical levels to delineate its implied utility as a novel complementary adjuvant therapy for cancer treatment.
DNA binding and transcription activation by chicken interferon regulatory factor-3 (chIRF-3) (2000)

Interferon regulatory factors (IRFs) are a family of transcription factors involved in the cellular response to interferons and viral infection. Previously we isolated an IRF from a chicken embryonic liver cDNA library. Using a PCR-based binding site selection assay, we have characterised the binding specificity of chIRF-3. The optimal binding site (OBS) fits within the consensus interferon-stimulated response element (ISRE) but the specificity of chIRF-3 binding allows less variation in nucleotides outside the core IRF-binding sequence. A comparison of IRF-1 and chIRF-3 binding to ISREs in electrophoretic mobility shift assays confirmed that the binding specificity of chIRF-3 was clearly distinguishable from IRF-1. The selection assay also showed that chIRF-3 is capable of binding an inverted repeat of two half OBSs separated by 10-13 nt. ChIRF-3 appears to bind both the OBS and inverted repeat sites as a dimer with the protein-protein interaction requiring a domain between amino acids 117 and 311. In transfection experiments expression of chIRF-3 strongly activated a promoter containing the OBS. The activation domain was mapped to between amino acids 138 and 221 and a domain inhibitory to activation was also mapped to the C-terminal portion of chIRF-3.
Simulation of Viscoelastic Polymer Flooding - From the Lab to the Field (2018)

Abstract Experimental data in numerous publications show that viscoelastic polymers can significantly reduce residual oil saturation under favorable conditions. The effect of viscoelasticity is in addition to improved sweep efficiency of polymer flooding. The residual oil saturation decreases with increasing dimensionless Deborah number (a measure of the relative elasticity). We used these extensive coreflood data to develop a new model that is referred to here as an Elastic Desaturation Curve (EDC). The new EDC model was implemented into a reservoir simulator and used to simulate polymer floods at both the lab and field scales. The simulated coreflood results match the experimental oil cut, oil recovery and pressure drop data. The simulator was then used to predict the effectiveness of polymer floods in a quarter five-spot well pattern under favorable field conditions. The field-scale simulations show that a viscoelastic polymer flood can recover significantly more oil (12% OOIP for the base case simulation) compared to an inelastic polymer flood of the same polymer viscosity. A sensitivity analysis shows that polymer concentration, salinity, well spacing, permeability, heterogeneity and injection rate affect the incremental oil recovery due to elasticity. The results suggest that the use of viscoelastic polymers could be a beneficial enhanced oil recovery strategy at the field scale under favorable conditions.
Nebulisers for bronchiectasis (1997)

from scanty to copious. Patients with bronchiectasis have a number of other symptoms ‐ pectorated fluid/mucus by a small amount, similar to the weight of the nebulised solution some are breathless with impaired lung function, usually predominantly an obstructive (only a 25% increase in the expectorated weight compared with physiotherapy alone). Interestventilatory defect, and asthma is frequent with an incidence of 28% (10 of 36) and 39% (nine ingly, nebulised terbutaline also increased the radioaerosol clearance rate in patients with
Microfiltration of Buttermilk and Washed Cream Buttermilk for Concentration of Milk Fat Globule Membrane Components (2007)

Buttermilk, the by-product from butter manufacture, has gained much attention lately because of the application potential of its milk fat globule membrane (MFGM) components as health ingredients. Microfiltration (MF) has been studied for buttermilk fractionation because of its ability to separate particles from dissolved solutes. However, the presence in this by-product of skim milk solids, especially casein micelles, restricts concentration of MFGM. The use of cream washed with skim milk ultrafiltrate to produce buttermilk with lower casein content was studied as well as fractionation of this buttermilk by MF. Results have shown that washing the cream prior to churning yields buttermilk with 74% less protein than normal cream buttermilk. Analysis of the protein profile of washed cream buttermilk revealed that caseins and whey proteins were the main classes of proteins removed. The MF of washed cream buttermilk resulted in permeation fluxes 2-fold higher than with normal cream buttermilk. The second separation of the cream induced high losses of phospholipids in the skim phase. However, retention of remaining phospholipids in washed cream buttermilk by the MF membrane was higher resulting in a phospholipids concentration factor 66% higher than that of normal cream buttermilk. The results presented in this study highlight the impact of casein micelles on the separation of MFGM components as well as their effect on permeation flux during MF.
Decentralized detection in sensor networks (2003)

In this paper, we investigate a binary decentralized detection problem in which a network of wireless sensors provides relevant information about the state of nature to a fusion center. Each sensor transmits its data over a multiple access channel. Upon reception of the information, the fusion center attempts to accurately reconstruct the state of nature. We consider the scenario where the sensor network is constrained by the capacity of the wireless channel over which the sensors are transmitting, and we study the structure of an optimal sensor configuration. For the problem of detecting deterministic signals in additive Gaussian noise, we show that having a set of identical binary sensors is asymptotically optimal, as the number of observations per sensor goes to infinity. Thus, the gain offered by having more sensors exceeds the benefits of getting detailed information from each sensor. A thorough analysis of the Gaussian case is presented along with some extensions to other observation distributions.
Osteoblast attachment to a textured surface in the absence of exogenous adhesion proteins (2003)

The present study investigated whether osteoblasts could attach to a culture substratum through a surface texture-dependent mechanism. Four test groups were used: (A) untextured, and three texture groups with maximum feature sizes of (B) <0.5 microm, (C) 2 microm, and (D) 4 microm, respectively. All surfaces were coated with the nonadhesive protein bovine serum albumin (BSA). Osteoblasts were allowed to adhere in serum-free medium for either 1 or 4 h, at which time nonadherent cells were removed. At 4 h, untextured surface A exhibited no cell attachment, while textured surfaces B, C, and D exhibited 9%, 32%, and 16% cell adhesion, respectively. At 16 h of incubation, adherent osteoblasts on textured surface C exhibited focal adhesion contacts and microfilament stress-fiber bundles. These results indicate that microtextured surfaces in the absence of exogenous adhesive proteins can facilitate osteoblast adhesion.
An energy efficient power control mechanism for base stations in mobile communication systems (2011)

The development of ICT (Information and Communication Technology) industry has emerged as one of the major sources of world energy consumption Especially, energy consumption on base station is a large portion of total energy consumption In this paper we study with energy efficient power control mechanism for base station in mobile communication systems. We proposed a efficient sector power control based on distance between base station and mobile node. Also we proposed a sleep mode energy control mechanism In sleep mode energy saving protocol, each sector monitors the number of user in sector cell. If number of mobile node falls down a given threshold in sector cell, base station shuts down power. Simulation demonstrate the Tx energy of proposed algorithms and the tradeoff between energy saving and cell coverage
20 Gbit/s optically regenerated transmission over 40 mm based on polarisation-independent, push-pull InP Mach-Zehnder modulator (2002)

Validation of a new polarisation-independent InP Mach-Zehnder interferometer providing adjustable phase/intensity optical modulation as a soliton regenerator is made through loop experiments. Error-free 20 Gbit/s transmission over 40,000 km is obtained in push-pull mode to compare with 8,000 km under single-electrode control.
The human PAF complex coordinates transcription with events downstream of RNA synthesis (2005)

The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. We report the isolation and functional characterization of the human PAF (hPAF) complex. hPAF shares four subunits with yPAF (hCtr9, hPaf1, hLeo1, and hCdc73), but contains a novel higher eukaryotic-specific subunit, hSki8. RNAi against hSki8 or hCtr9 reduces the cellular levels of other hPAF subunits and of mono- and trimethylated H3-Lys 4 and dimethylated H3-Lys 79. The hSki8 subunit is also a component of the human SKI (hSKI) complex. Yeast SKI complex is cytoplasmic and together with Exosome mediates 3'-5' mRNA degradation. However, hSKI complex localizes to both nucleus and cytoplasm. Immunoprecipitation experiments revealed that hPAF and hSKI complexes interact, and ChIP experiments demonstrated that hSKI associates with transcriptionally active genes dependent on the presence of hPAF. Thus, in addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control.
A New Semiconductor Tetrode-The Surface-Potential Controlled Transistor (1961)

The theory and operating characteristics of a new semiconductor tetrode is discussed in this paper. This semiconductor junction device has the usual geometry of the planar transistor, but with an additional metal electrode placed on the oxide which covers the surface of the emitter-base junction. This electrode serves as a grid. The grid-base voltage controls the surface potential, surface recombination rate and the size of the surface channel, and thereby the current gain of the transistor. In the common emitter connection the grid serves as a second input in addition to the base input. Input impedance of the grid is typically in the range of 1 to 100 pf and 1015 ohms. Transconductances dIC/dVGE of several thousand micromhos have been achieved in the common emitter connection. The cutoff frequency of the transconductance is approximately the same as that of the hfe.
Role of tol genes in cloacin DF13 susceptibility of Escherichia coli K-12 strains expressing the cloacin DF13-aerobactin receptor IutA (1993)

IutA is the outer membrane protein receptor for ferric aerobactin and the bacteriocin cloacin DF13. Although the same receptor is shared, ferric aerobactin transport across the outer membrane in Escherichia coli is TonB dependent, whereas cloacin DF13 transport is not. We have recently observed that tolQ is required for cloacin DF13 susceptibility (J.A. Thomas and M.A. Valvano, FEMS Microbiol. Lett. 91:107-112, 1992). In this study, we demonstrate that the genes tolQ, tolR, and tolA, but not tolB, tolC, and ompF, are required for the internalization of cloacin DF13 and they are not involved in the transport of ferric aerobactin.
Jena: a semantic Web toolkit (2002)

HP Labs developed the Jena toolkit to make it easier to develop applications that use the semantic Web information model and languages. Jena is a Java application programming interface that is available as an open-source download from www.hpl.hp.com/semweb/jena-top.html.
Phase-Based UHF RFID Tracking With Nonlinear Kalman Filtering and Smoothing (2011)

In this paper, we present an UHF RFID location tracking system, which is based on measuring the phases of back scattered signals from RFID tag using multiple spatially distributed antennas at a single carrier frequency. The wavelength ambiguity of the phase measurements is resolved by using the extended Kalman filter (EKF) and the Rauch-Tung-Striebel (RTS) smoother, where the state includes the position, velocity and the phase offsets of antennas. The performance of the method is experimentally verified at 890 MHz using a commercially available RFID reader.
Multilateral Filter Denoising Method Based on Meanshift for Point-Sampled Model (2009)

In order to remove the noise in point-sampled model, and prevent vertex drift and over-smoothing phenomenon, a multilateral filter denoising algorithm based on Meanshift for point-sample model is presented. First of all, the algorithm defines the neighborhood for each sampling point based on Euclidean distance; normals and curvatures of vertices in the neighborhood are estimated by covariance matrix analysis and the local optimal neighborhood of sampled point is determined by using Meanshift method. Then, the pre-smoothing normals of sampled points are calculated in the neighborhood to obtain the filter reference plane. Finally, by moving vertices to new locations, the final model after denoising is obtained. The experimental results show that our algorithm can effectively remove the noise, and can maintain local geometric characteristics of the model.
MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. (2006)

Patterns of injury detected by standard anatomic imaging sequences, DTI sequences, and proton MR spectroscopy varied considerably during the first 2 weeks after injury. The appearance of new areas of reduced diffusion simultaneous with the pseudonormalization of areas that had reduced diffusion at earlier times can result in an entirely different pattern of injury on diffusivity maps acquired at different time points. Awareness of these evolving patterns is essential if studies are performed and interpreted during this critical period of time.
The Basic Helix-Loop-Helix/PAS Factor Sim Is Associated with hsp90: (1995)

Sim is a Drosophila developmental basic helix-loop-helix (bHLH) transcription factor containing a Per-Arnt-Sim (PAS) region of homology. Here we demonstrate that Sim, in analogy to the structurally related bHLH/PAS dioxin receptor, was stably associated with the molecular chaperone hsp90. In the case of the dioxin receptor, release of hsp90 and derepression of receptor function appear to be regulated by ligand binding and dimerization with Arnt, a non-hsp90-associated bHLH/PAS factor. Dimerization with Arnt very efficiently disrupted Sim-hsp90 interaction, a process that required both the bHLH and PAS dimerization motifs of Arnt. Moreover, hsp90 was also released upon dimerization of Sim with the Drosophila PAS factor Per, whereas the hsp90-associated dioxin receptor failed to interact with Sim. These results indicate that hsp90 may play a role in conditional regulation of Sim function, and that Per and possibly bHLH/PAS partner factors may activate Sim by inducing release of hsp90 during the dimerization process.
Quasi-optical millimeter-wave band-pass filters using high-T/sub c/ superconductors (1991)

Quasioptical millimeter-wave band-pass filters using YBa/sub 2/Cu/sub 3/O/sub 7/ high-T/sub c/ superconducting films were fabricated on MgO and LaAlO/sub 3/ substrates. Transmitted power through the filter was investigated in the 75 GHz to 110 GHz frequency range at temperatures ranging from 15 to 300 K. At 15 K the measured center frequency and the bandwidth of the superconducting filter were 92 GHz and 0.85 GHz, respectively. Measurements of YBa/sub 2/Cu/sub 3/O/sub 7/ filters were compared with similar filters fabricated using gold. At 15 K and 92 GHz, an improvement of 75% in the quality factor of the superconducting filter was obtained compared with a similar gold filter.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Quaternary ammonium salts : their use in phase-transfer catalysed reactions (2001)

Preface Abbreviations General Principles Simple Nucleophilic Exchange Reactions and Aromatic Substitution Reactions Formation of C--O Bonds Formation of C--S Bonds and Related Reactions Formation of C--N Bonds and Related Reactions Formation of C--C Bonds Preparation and Synthetic Applications of Carbenes Carbonylation and Other Reactions Elimination Reactions, Cleavage and Rearrangement Reactions Isomerism and H/D Exchange Reactions Oxidation of Organic Compounds Reduction of Organic Compounds Stereoselective Control in Phase-Transfer Catalyzed Reactions
Puerarin inhibits M2 polarization and metastasis of tumor-associated macrophages from NSCLC xenograft model via inactivating MEK/ERK 1/2 pathway (2017)

Non-small cell lung carcinoma (NSCLC) metastasis is responsible for most of cancer-related mortality. The tumor associated macrophages (TAMs) are known to be crucial cells in lung cancer and are usually divided into two antagonistic types, M1 and M2. Puerarin has a wide spectrum of pharmacological properties. The present study explores puerarin on macrophage polarization and metastasis of NSCLC. The results demonstrated that puerarin inhibited tumor growth and tumor volumes in NSCLC xenograft model, increased M1 markers [CD197+, inducible nitric oxide synthase (iNOS)+, CD40+)] and reduced M2 markers (CD206+, Arg-1+ and CD163+). Besides, puerarin elevated the level of pro-inflammatory cytokine interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin (IL)-12, decreased the expression of pro-tumor cytokines IL-10, IL-4 and transforming growth factor (TGF)-β. To explore whether puerarin directly acts on macrophages, we purified macrophages from NSCLC model, the results showed that puerarin inhibited macrophages polarized to M2 phenotype and did not require the auxiliary of other cells. In addition, puerarin suppressed the invasion and migration of NSCLC macrophages, restrained the expression of angiogenesis factors. Puerarin also inhibited the activation of mitogen-activated extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) 1/2 pathway through inhibition of ERK nucleus translocation. Finally, IL-4 induced M2 macrophage polarization and metastasis were partially offset by puerarin through inactivating the MEK/ERK 1/2 pathway. Taken together, this study validated that puerarin is able to skew macrophage populations back to M1 subsets to stimulate antitumor effects and suggests puerarin is a negative metastatic regulator of NSCLC.
Lens Matching And Distortion Testing In A Multi-Stepper, Sub-Micron Environment (1989)

Step and repeat camera optical systems today exhibit greater resolution, numerical aperture and field sizes than in the past. It has become necessary to control lens distortion and matching errors to less than one-tenth micron across the entire usable field. The quality of the optics has risen to the point that fifth order distortion modeling has become a necessary component of the stepper matching procedure. Methods of data gathering and analysis vary significantly in the industry. In this paper we investigate four methods of overlay measurement including electrical, optical coherence probe, automated optical and optical vernier techniques. Precision to tolerance ratios and throughput for the measurement methods are discussed. Three methods of data analysis are compared including KLASS II for KLA 2020* data, EM1** for electrical data and SASO*** for both. A novel multi-substrate calibration technique is presented. In any matching situation the required sample size for accurate estimation of the lens components is important. Our study reviews the results of analyses of variances due to daily repeatability, wafer films, the number of measurement sites on each wafer and stepped field. Two methods of artifact generation were investigated, that of stage referenced matching and matching to a 'golden standard'. Finally, the expansion of the model to include seventh order distortions and the significance of this for the now emerging high numerical aperture, large field g-line lens designs is discussed.
Stereochemical Analysis of the Reaction Catalyzed by Human Protein Geranylgeranyl Transferase (2001)

Protein geranylgeranyltransferase type I (PGGTase-I) catalyzes the nucleophilic substitution reaction between the C(20) geranylgeranyl diphosphate (GGPP) and a protein-derived thiol to form a thioether linkage. Here, we describe the stereochemical outcome, at the isoprenoid C1, of the reaction catalyzed by human PGGTase-I. To accomplish this, the pentapeptide N-dansyl-GCVLL was first enzymatically prenylated by human PGGTase-I with either (S)-[1-(2)H]farnesyl diphosphate or (S)-[1-(2)H]GGPP. The prenylated products were then degraded to dipeptides using carboxypeptidase Y. After HPLC purification, the prenylated dipeptide products were analyzed by (1)H NMR spectroscopy. The final spectra were compared with the spectra from the same product obtained via chemical synthesis to deduce the stereochemistry of the PGGTase-I-catalyzed reaction. This comparison showed that the reaction proceeds with inversion of configuration with no detectable (< 6%) racemization. These results are more consistent with an associative-type mechanism, but they cannot be used to rule out a dissociative mechanism involving a rigid, solvent-sequestered, tight ion pair.
Characteristics of staggered InGaN quantum wells light-emitting diodes emitting at 480&#x2013;525 nm (2009)

In this work, we present simulation and experimental studies of staggered InGaN QWs LEDs emitting at 480nm and 525-nm spectral regimes. The staggered InGaN QW design can be realized by employing combination of high In-content and low In-content InGaN layers to form the QW with significantly improved electron-hole wave function overlap. This leads to the enhancement in radiative efficiency of nitride LEDs.The power-dependent cathodoluminescence measurements exhibited enhancement of 2.5-times for staggered InGaN QWs. The electroluminescence output power for electrically-injected staggered InGaN QW LEDs exhibited improvement by 2.5-3.5 times for emission in the green spectal regime.