gebhart/patrepeval huggingface dataset:
Tenascin-R Inhibits the Growth of Optic Fibers<i>In Vitro</i>But Is Rapidly Eliminated during Nerve Regeneration in the Salamander<i>Pleurodeles waltl</i> (1999)

Tenascin-R is a multidomain molecule of the extracellular matrix in the CNS with neurite outgrowth inhibitory functions. Despite the fact that in amphibians spontaneous axonal regeneration of the optic nerve occurs, we show here that the molecule appears concomitantly with myelination during metamorphosis and is present in the adult optic nerve of the salamander Pleurodeles waltl by immunoblots and immunohistochemistry. In vitro, adult retinal ganglion cell axons were not able to grow from retinal explants on a tenascin-R substrate or to cross a sharp substrate border of tenascin-R in the presence of laminin, indicating that tenascin-R inhibits regrowth of retinal ganglion cell axons. After an optic nerve crush, immunoreactivity for tenascin-R was reduced to undetectable levels within 8 d. Immunoreactivity for the myelin-associated glycoprotein (MAG) was also diminished by that time. Myelin was removed by phagocytosing cells at 8-14 d after the lesion, as demonstrated by electron microscopy. Tenascin-R immunoreactivity was again detectable at 6 months after the lesion, correlated with remyelination as indicated by MAG immunohistochemistry. Regenerating axons began to repopulate the distal lesioned nerve at 9 d after a crush and grew in close contact with putative astrocytic processes in the periphery of the nerve, close to the pia, as demonstrated by anterograde tracing. Thus, the onset of axonal regrowth over the lesion site was correlated with the removal of inhibitory molecules in the optic nerve, which may be necessary for successful axonal regeneration in the CNS of amphibians.
Oxytocin Makes a Face in Memory Familiar (2009)

Social recognition is the basis of all social interactions. Here, we show that, in humans, the evolutionarily highly conserved neuropeptide oxytocin, after intranasal administration, specifically improves recognition memory for faces, but not for nonsocial stimuli. With increased oxytocin levels, previously presented faces were more correctly assessed as "known," whereas the ability of recollecting faces was unchanged. This pattern speaks for an immediate and selective effect of the peptide strengthening neuronal systems of social memory.
Designing for Learning Using Social Networking (2017)

Abstract Social networking platforms such as Facebook have infiltrated the lives of many students, and as such it is natural to consider how they can be effectively used to enhance learning. This chapter provides a comprehensive review of social networking in education from a design perspective. Social networking is defined based on Boyd & Ellison’s seminal definition of connected profiles, and is distinguished from social media for the purposes of investigation. Facebook, Edmodo, and other social networking platforms are briefly described, before summarizing the wide variety of social networking usage reported in the research literature. The various benefits of social networking in education are distilled from the literature, including their capacity to facilitate community building, collaboration, reflection, and expedient access to learning. Issues surrounding the educational use of social networking are also organized into themes, for instance privacy concerns, distraction, cyber-safety, and technical constraints. The implications of findings from the social networking literature are synthesized into learning design and implementation recommendations. The chapter concludes with a discussion of open questions and areas for further investigation.
Loss of heterozygosity in chondrosarcomas for markers linked to hereditary multiple exostoses loci on chromosomes 8 and 11. (1995)

Hereditary multiple exostoses (EXT; MIM 133700) is an autosomal dominant condition characterized by growth of multiple benign cartilage-capped tumors. EXT greatly increases the relative risk to develop chondrosarcoma, although most chondrosarcomas are sporadic. This observation suggests that, like the genes responsible for retinoblastoma and other dominantly inherited cancer susceptibility disorders, the genes that cause EXT may have tumor-suppressor function and may play a role in the pathogenesis of the related sporadic tumors. To investigate this hypothesis, we evaluated chondrosarcomas for loss of constitutional heterozygosity (LOH) at polymorphic loci linked to three recently identified genomic regions containing genes involved in EXT. LOH for markers linked to EXT1 on chromosome 8 was detected in a chondrosarcoma that arose in a man with EXT. Four of 17 sporadic tumors showed LOH for markers linked to EXT1, and 7 showed LOH for markers linked to EXT2 on chromosome 11. In all, LOH was observed for markers linked to EXT1 or EXT2 in 44% of the 18 tumors, whereas heterozygosity was retained for markers on 19p linked to EXT3. These findings support the hypothesis that genes on 8q and the pericentromeric region of 11 have tumor-suppressor function and play a role in the development of chondrosarcomas.
Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD (2002)

Intimal enlargement of pulmonary arteries is an early change in chronic obstructive pulmonary disease (COPD). The cellular and extracellular components that are involved in this enlargement are unknown. The present study was designed to characterize the structural changes occurring in pulmonary muscular arteries in the initial disease stages. Lung specimens from patients with moderate COPD (n=8; forced expiratory volume in one second (FEV1), 66 +/- 10% predicted) and smokers without airflow obstruction (n=7; FEV1, 86 +/- 6% pred), were investigated by histochemistry to characterize extracellular matrix proteins and by immunohistochemistry to identify intrinsic cells of the vascular wall. In both COPD patients and smokers, the majority of cells present in the enlarged intimas were stained by specific smooth muscle cell (SMC) markers. No staining with endothelial or fibroblast markers was shown. A proportion of SMCs did not stain with desmin, suggesting cellular heterogeneity in this population. Elastin was the most abundant extracellular matrix protein and collagen was seen in a lower proportion. The amount of collagen was related to the intimal thickness (p<0.001). The findings demonstrated smooth muscle cell proliferation, as well as elastin and collagen deposition, in the thickened intimas of pulmonary arteries in moderate chronic obstructive pulmonary disease patients and smokers, suggesting that these abnormalities may originate at an early stage in cigarette smoke-induced respiratory disease.
Visual influences on auditory spatial learning (2008)

The visual and auditory systems frequently work together to facilitate the identification and localization of objects and events in the external world. Experience plays a critical role in establishing and maintaining congruent visual-auditory associations, so that the different sensory cues associated with targets that can be both seen and heard are synthesized appropriately. For stimulus location, visual information is normally more accurate and reliable and provides a reference for calibrating the perception of auditory space. During development, vision plays a key role in aligning neural representations of space in the brain, as revealed by the dramatic changes produced in auditory responses when visual inputs are altered, and is used throughout life to resolve short-term spatial conflicts between these modalities. However, accurate, and even supra-normal, auditory localization abilities can be achieved in the absence of vision, and the capacity of the mature brain to relearn to localize sound in the presence of substantially altered auditory spatial cues does not require visuomotor feedback. Thus, while vision is normally used to coordinate information across the senses, the neural circuits responsible for spatial hearing can be recalibrated in a vision-independent fashion. Nevertheless, early multisensory experience appears to be crucial for the emergence of an ability to match signals from different sensory modalities and therefore for the outcome of audiovisual-based rehabilitation of deaf patients in whom hearing has been restored by cochlear implantation.
PVC reservation on shared buffer type ATM switch for data communication (2002)

This paper describes an ATM switch with a PVC (permanent virtual connection) reservation function, which reserves a PVC identifier when each cells stream arrives at the switch unless the sum of the peak bandwidths of the cell streams exceeds the output link throughput of the switch. Only reserved PVC cell streams can pass through the switch completely without interference from unreserved streams. We have already developed one-board ATM switch forming 128 queues on the 4,000-cell shared buffer for bandwidth control. It is feasible to achieve a PVC reservation by allotting one PVC cell stream to one queue at the switch forming multiple queues for each output port.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hippocampal Network Hyperactivity After Selective Reduction of Tonic Inhibition in GABA<sub>A</sub> Receptor α5 Subunit–Deficient Mice (2006)

Functionally, gamma-aminobutyric acid receptor (GABAR)-mediated inhibition can be classified as phasic (synaptic) and tonic (extrasynaptic). The GABARs underlying tonic inhibition assemble from subunits different from those responsible for phasic inhibition. We wanted to assess the excitability of hippocampal pyramidal cell (PC) networks following a selective impairment of tonic inhibition. This is difficult to accomplish by pharmacological means. Because the GABAR alpha5 subunits mostly mediate the tonic inhibition in CA1 and CA3 PCs, we quantified changes in tonic inhibition and examined network excitability in slices of adult gabra5-/- mice. In gabra5-/- CA1 and CA3 PCs tonic inhibitory currents were 60 and 53%, respectively, of those recorded in wild type (WT), with no alterations in phasic inhibition. The amount of tonic inhibition recorded in slices was significantly affected by the method of slice storage (interface or submerged chamber). Field recordings in gabra5-/- CA3 pyramidal layer showed an increased network excitability that was decreased by the GABAR agonist muscimol at a concentration that restored the tonic inhibition of gabra5-/- PCs to the WT level without altering phasic inhibition. Through a battery of pharmacological experiments, we have identified delta subunit-containing GABARs as the mediators of the residual tonic inhibition in gabra5-/- PCs. Our study is consistent with an important role of tonic inhibition in the control of hippocampal network excitability and highlights selective enhancers of tonic inhibition as promising therapeutic approaches for diseases involving network hyperexcitability.
Neural Modularity Helps Organisms Evolve to Learn New Skills without Forgetting Old Skills (2015)

International audience
Home Care- For Patients or for Profit? (1985)

No abstract available for this article.
Qualification of a Time-of-Flight Camera as a Hazard Detection and Avoidance Sensor for a Moon Exploration Microrover (2018)

This paper describes the methodology used for the implementation of a time-of-flight (ToF) camera in a lunar exploration microrover as a hazard detection and avoidance (HDA) sensor. Each frame from the ToF camera provides a 3D point cloud of the environment. Such data have unique advantages for autonomous hazard detection. First, we investigate the durability of the ToF camera system to survive the launch and space environment and report the results of qualification tests: a vibration test, thermal vacuum test, and radiation test. Second, we focus on the critical optical performance under lunar surface illumination conditions. We present the rationale and implementation of the first improvement made to the commercial version of the sensor to better suit strong illumination conditions. We conducted optical testing to verify that the quality of the 3D point cloud is sufficiently reliable for input into the HDA algorithm. Finally, we implemented a proof-of-concept algorithm and performed field testing of the integrated detection, analysis and command chain. Through this research, a terrestrial sensor is qualified and customized to provide the data quality capable of autonomous hazard detection and avoidance on the lunar surface.
High-Efficiency Convolutional Ternary Neural Networks with Custom Adder Trees and Weight Compression (2018)

Although performing inference with artificial neural networks (ANN) was until quite recently considered as essentially compute intensive, the emergence of deep neural networks coupled with the evolution of the integration technology transformed inference into a memory bound problem. This ascertainment being established, many works have lately focused on minimizing memory accesses, either by enforcing and exploiting sparsity on weights or by using few bits for representing activations and weights, to be able to use ANNs inference in embedded devices. In this work, we detail an architecture dedicated to inference using ternary {−1, 0, 1} weights and activations. This architecture is configurable at design time to provide throughput vs. power trade-offs to choose from. It is also generic in the sense that it uses information drawn for the target technologies (memory geometries and cost, number of available cuts, etc.) to adapt at best to the FPGA resources. This allows to achieve up to 5.2k frames per second per Watt for classification on a VC709 board using approximately half of the resources of the FPGA.
Adaptive power control in CDMA cellular communication systems (2005)

Power control is an essential radio resource management method in CDMA cellular communication systems, where co-channel interference is the primary capacity-limiting factor. Power control aims to control the transmission power levels in such a way that acceptable quality of service for the users is guaranteed with lowest possible transmission powers. All users benefit from the minimized interference and the preserved signal qualities.\n\nIn this thesis new closed loop power control algorithms for CDMA cellular communication systems are proposed. To cope with the random changes of the radio channel and interference, adaptive algorithms are considered that utilize ideas from self-tuning control systems. The inherent loop delay associated with closed loop power control can be included in the design process, and thus alleviated with the proposed methods. Another problem in closed-loop power control is that extensive control signaling consumes radio resources, and thus the control feedback bandwidth must be limited. A new approach to enhance the performance of closed-loop power control in limited-feedback-case is presented, and power control algorithms based on the new approach are proposed.\n\nThe performances of the proposed algorithms are evaluated through both analysis and computer simulations, and compared with well-known algorithms from the literature. The results indicate that significant performance improvements are achievable with the proposed algorithms.
Alarm Algorithms in Critical Care Monitoring (2006)

The alarms of medical devices are a matter of concern in critical and perioperative care. The frequent false alarms not only are a nuisance for patients and caregivers but can also compromise patient safety and effectiveness of care. The development of alarm systems has lagged behind the technological advances of medical devices over the last 20 years. From a clinical perspective, major improvements of alarm algorithms are urgently needed. We give an overview of the current clinical situation and the underlying problems and discuss different methods from statistics and computational science and their potential for clinical application.
Fluid flow aspects of twin-screw extruder process: numerical simulations of TSE rheomixing (2003)

This paper presents a brief review of the twin-screw extruder (TSE) process, analyses the fluid flow aspects of a new application of TSE in rheomixing casting, and simulates fundamental micro-mechanisms of the rheological behaviour of metallurgical alloys. The TSE is widely used as a mixing tool in the polymer industry. The numerical simulation of the TSE process is complex and there are only few simulation packages to provide an insight into TSE processing for viscoelastic flows. This study involves the systematic analysis of flow features of immiscible alloys in the TSE rheomixing process, the establishment of a simplified flow field, and simulation of the microstructure of immiscible alloy drops by the piecewise linear interface construction/volume-of-fluid method. It is noted that the microstructure of immiscible alloys is strongly influenced by the viscosity of the system, which dominates the interaction between droplets. The numerical results show good qualitative agreement with experimental results, and are useful for further optimization design of prototypical rheomixing processes.
Comorbidities of Diabetes and Hypertension: Mechanisms and Approach to Target Organ Protection (2011)

Up to 75% of adults with diabetes also have hypertension, and patients with hypertension alone often show evidence of insulin resistance. Thus, hypertension and diabetes are common, intertwined conditions that share a significant overlap in underlying risk factors (including ethnicity, familial, dyslipidemia, and lifestyle determinants) and complications. These complications include microvascular and macrovascular disorders. The macrovascular complications, which are well recognized in patients with longstanding diabetes or hypertension, include coronary artery disease, myocardial infarction, stroke, congestive heart failure, and peripheral vascular disease. Although microvascular complications (retinopathy, nephropathy, and neuropathy) are conventionally linked to hyperglycemia, studies have shown that hypertension constitutes an important risk factor, especially for nephropathy. The familial predisposition to diabetes and hypertension appears to be polygenic in origin, which militates against the feasibility of a "gene therapy" approach to the control or prevention of these conditions. On the other hand, the shared lifestyle factors in the etiology of hypertension and diabetes provide ample opportunity for nonpharmacologic intervention. Thus, the initial approach to the management of both diabetes and hypertension must emphasize weight control, physical activity, and dietary modification. Interestingly, lifestyle intervention is remarkably effective in the primary prevention of diabetes and hypertension. These principles also are pertinent to the prevention of downstream macrovascular complications of the two disorders. In addition to lifestyle modification, most patients will require specific medications to achieve national treatment goals for hypertension and diabetes. Management of hyperglycemia, hypertension, dyslipidemia, and the underlying hypercoagulable and proinflammatory states requires the use of multiple medications in combination.
Wireless portals with wifidog (2005)

Wifidog teaches WIFI hotspots new tricks. Leave your Wi-Fi access point open, but control and monitor its use.
Interleukin-6 Stimulates Hepatic Insulin-Like Growth Factor Binding Protein-4 Messenger Ribonucleic Acid and Protein (2001)

Sepsis and bacterial lipopolysaccharide (LPS) injection decrease circulating concentrations of insulin-like growth factor (IGF)-I and induce an increase in IGFBP-1 and IGFBP-4 that may have impact upon IGF-I anabolic actions. Although the mechanisms responsible for the IGFBP-1 increase in response to LPS have already been unraveled, the cause for the IGFBP-4 elevation is still unknown. The aim of this study was to characterize the regulation of IGFBP-4 by proinflammatory cytokines and glucocorticoids. In rat primary cultured hepatocytes, interleukin (IL)-6 strongly stimulated IGFBP-4 messenger RNA (mRNA) and protein levels in a dose- and time-dependent way (mRNA levels: 9-fold, P: < 0.01 and protein levels: approximately 3-fold at 24 h, with IL-6 10 ng/ml). Interleukin (IL)-1ss and tumor necrosis factor (TNF)-alpha blunted the IL-6 stimulation of IGFBP-4 mRNA (66% and 46% decrease, respectively) and protein levels (82% and 68% decrease, respectively). In contrast, dexamethasone induced IGFBP-4 mRNA and protein and potentiated the effect of IL-6 on IGFBP-4 mRNA (2.5-fold, P: < 0.01 vs. IL-6 alone). Both actinomycin and cycloheximide prevented the IL-6 induction of IGFBP-4 mRNA suggesting that the IL-6 effect on IGFBP-4 gene occurs probably at the transcriptional level and needs an ongoing protein synthesis. Administration of IL-6 to rats caused a 3-fold increase in liver IGFBP-4 mRNA (P: < 0.001) reflected in serum levels of IGFBP-4 (P: < 0.05). In conclusion, our results show that IL-6 stimulates hepatic IGFBP-4 gene expression and production in vitro and in vivo, thereby suggesting another mechanism by which cytokines could control IGF-I action.
Cardiovascular Effects of Sodium Nitroprusside in Cerebral Aneurysm Surgery (1980)

Cardiovascular effects of sodium nitroprusside (SNP) were studied in 17 patients undergoing cerebral aneurysm surgery under controlled hypotension. In 10 patients oxygen uptake was also calculated. Mean arterial blood pressure was decreased from 91 to 58 mmHg by SNP due to reductions in both total peripheral resistance (29%) and cardiac output (15%). Mean right atrial and pulmonary capillary wedge pressures were reduced during hypotension. Total oxygen uptake remained constant throughout the procedure. There was no significant change in arterial oxygen tension in the hypotensive period, but after discontinuation of SNP infusion it was significantly increased. The haemodynamic effects of SNP in patients with a recent subarachnoid haemorrhage and its effect on blood oxygenation are discussed. It is concluded that the fall in cardiac output is related to a reduction of central blood volume and might be more pronounced in these patients than in normal subjects.
Universal quantum gates for photon-atom hybrid systems assisted by bad cavities (2015)

We present two deterministic schemes for constructing a CNOT gate and a Toffoli gate on photon-atom and photon-atom-atom hybrid quantum systems assisted by bad cavities, respectively. They are achieved by cavity-assisted photon scattering and work in the intermediate coupling region with bad cavities, which relaxes the difficulty of their implementation in experiment. Also, bad cavities are feasible for fast quantum operations and reading out information. Compared with previous works, our schemes do not need any auxiliary qubits and measurements. Moreover, the schematic setups for these gates are simple, especially that for our Toffoli gate as only a quarter wave packet is used to interact the photon with each of the atoms every time. These atom-cavity systems can be used as the quantum nodes in long-distance quantum communication as their relatively long coherence time is suitable for multi-time operations between the photon and the system. Our calculations show that the average fidelities and efficiencies of our two universal hybrid quantum gates are high with current experimental technology.