gebhart/patrepeval huggingface dataset:
Neural Basis of Endogenous and Exogenous Spatial Orienting: A Functional MRI Study (1999)

Whole-brain functional magnetic resonance imaging (MRI) was used to examine the neural substrates of internally (endogenous) and externally (exogenous) induced covert shifts of attention. Thirteen normal subjects performed three orienting conditions: endogenous (location of peripheral target predicted by a central arrow 80% of the time), exogenous (peripheral target preceded by noninformative central cue). Behavioral results indicated faster reaction times (RTs) for valid than for invalid trials for the endogenous condition but slower RTs for valid than for invalid trials for the exogenous condition (inhibition of return). The spatial extent and intensity of activation was greatest for the endogenous condition, consistent with the hypothesis that endogenous orienting is more effortful (less automatic) than exogenous orienting. Overall, we did not observe distinctly separable neural systems associated with the endogenous and exogenous orienting conditions. Both exogenous and endogenous orienting, but not the control condition, activated bilateral parietal and dorsal premotor regions, including the frontal eye fields. These results suggest a specific role for these regions in preparatory responding to peripheral stimuli. The right dorsolateral prefrontal cortex (BA 46) was activated selectively by the endogenous condition. This finding suggests that voluntary, but not reflexive, shifts of attention engage working memory systems.
Image Analysis Based On Soft Computing And Applied On Space Shuttle Safety During The Liftoff Process (2008)

Imaging techniques based on Soft Computing (SC) and developed at Kennedy Space Center (KSC) have been implemented on a variety of prototype applications related to the safety operation of the Space Shuttle during the liftoff process. These SC-based prototype applications include detection and tracking of moving Foreign Objects Debris (FOD) during the Space Shuttle liftoff, visual anomaly detection on slidewires used in the emergency egress system for the Space Shuttle at the laJlIlch pad, and visual detection of distant birds approaching the Space Shuttle launch pad. This SC-based image analysis capability developed at KSC was also used to analyze images acquired during the accident of the Space Shuttle Columbia and estimate the trajectory and velocity of the foam that caused the accident.
Shear Strength Behaviors of Ceramic Matrix Composites at Elevated Temperatures (2006)

This chapter contains sections titled: Introduction Experimental Procedures Experimental Reults Discussion Conclusions
JEWS AND DEVILS: ANTI-SEMITIC STEREOTYPES OF LATE MEDIEVAL AND RENAISSANCE ENGLAND (1990)

JEWS AND DEVILS: ANTI-SEMITIC STEREOTYPES OF LATE MEDIEVAL AND RENAISSANCE ENGLAND Get access Frank Felsenstein Frank Felsenstein Search for other works by this author on: Oxford Academic Google Scholar Literature and Theology, Volume 4, Issue 1, March 1990, Pages 15–28, https://doi.org/10.1093/litthe/4.1.15 Published: 01 March 1990
Anti-mutagenic Activity of DNA Damage-binding Proteins Mediated by Direct Inhibition of Translesion Replication (1997)

DNA lesions that block replication can be bypassed in Escherichia coli by a special DNA synthesis process termed translesion replication. This process is mutagenic due to the miscoding nature of the DNA lesions. We report that the repair enzyme formamido-pyrimidine DNA glycosylase and the general DNA damage recognition protein UvrA each inhibit specifically translesion replication through an abasic site analog by purified DNA polymerases I and II, and DNA polymerase III (alpha subunit) from E. coli. In vivo experiments suggest that a similar inhibitory mechanism prevents at least 70% of the mutations caused by ultraviolet light DNA lesions in E. coli. These results suggest that DNA damage-binding proteins regulate mutagenesis by a novel mechanism that involves direct inhibition of translesion replication. This mechanism provides anti-mutagenic defense against DNA lesions that have escaped DNA repair.
Target architecture oriented high-level synthesis for multi-FPGA based emulation (2000)

This paper presents a new approach on combined highlevel synthesis and partitioning for FPGA-based multi-chip emulation systems. The goal is to synthesize a prototype with maximal performance under the given area and interconnection constraints of the target architecture. Interconnection resources are handled similarly to functional resources, enabling the scheduling and the sharing of interchip connections according to their delay. Moreover, data transfer serialization is performed completely or partially, depending on the mobility of the data transfers, in order to satisfy the given interconnection constraints. In contrast to conventional partitioning approaches, the constraints of the target architecture are fulfilled by construction.
The Bloom's Syndrome Helicase Unwinds G4 DNA (1998)

BLM, the gene that is defective in Bloom's syndrome, encodes a protein homologous to RecQ subfamily helicases that functions as a 3'-5' DNA helicase in vitro. We now report that the BLM helicase can unwind G4 DNA. The BLM G4 DNA unwinding activity is ATP-dependent and requires a short 3' region of single-stranded DNA. Strikingly, G4 DNA is a preferred substrate of the BLM helicase, as measured both by efficiency of unwinding and by competition. These results suggest that G4 DNA may be a natural substrate of BLM in vivo and that the failure to unwind G4 DNA may cause the genomic instability and increased frequency of sister chromatid exchange characteristic of Bloom's syndrome.
Alfalfa in Livestock Feeding Programs (1985)

A magazine article entitled "Bidders Paid More For Quality at Wisconsin Hay Auction" caught my attention. Did they really pay more money for higher quality. I could not help but think of some hay sales which I have witnessed. One dollar per bale, large bales, small round bales, sixty dollars per ton, and $275 per ton are all some quotes I have heard recently in connection with hay purchases. Not much is said about quality. We may hear relative terms such as good, not much grass, cut early, not rained on or others but not much about nutrient content or feed value.
Protein-Protein Coupling/Uncoupling Enables Dopamine D<sub>2</sub>Receptor Regulation of AMPA Receptor-Mediated Excitotoxicity (2005)

here is considerable evidence that dopamine D2 receptors can modulate AMPA receptor-mediated neurotoxicity. However, the molecular mechanism underlying this process remains essentially unclear. Here we report that D2 receptors inhibit AMPA-mediated neurotoxicity through two pathways: the activation of phosphoinositide-3 kinase (PI-3K) and downregulation of AMPA receptor plasma membrane expression, both involving a series of protein-protein coupling/uncoupling events. Agonist stimulation of D2 receptors promotes the formation of the direct protein-protein interaction between the third intracellular loop of the D2 receptor and the ATPase N-ethylmaleimide-sensitive factor (NSF) while uncoupling the NSF interaction with the carboxyl tail (CT) of the glutamate receptor GluR2 subunit of AMPA receptors. Previous studies have shown that full-length NSF directly couples to the GluR2CT and facilitates AMPA receptor plasma membrane expression. Furthermore, the CT region of GluR2 subunit is also responsible for several other intracellular protein couplings, including p85 subunit of PI-3K. Therefore, the direct coupling of D2-NSF and concomitant decrease in the NSF-GluR2 interaction results in a decrease of AMPA receptor membrane expression and an increase in the interaction between GluR2 and the p85 and subsequent activation of PI-3K. Disruption of the D2-NSF interaction abolished the ability of D2 receptor to attenuate AMPA-mediated neurotoxicity by blocking the D2 activation-induced changes in PI-3K activity and AMPA receptor plasma membrane expression. Furthermore, the D2-NSF-GluR2-p85 interactions are also responsible for the D2 inhibition of ischemia-induced cell death. These data may provide a new avenue to identify specific targets for therapeutics to modulate glutamate receptor-governed diseases, such as stroke.
The Composite Digital Format and its Applications (1987)

Two schools of thought exist regarding component versus composite digital video recording: that one recording method will “win” in the marketplace, or that, in the next decade at least, each format will find a place in different applications. The authors take the latter position in describing the composite format and comparing it to the component D-1 format. Encoding and mechanical parameters, record content, longitudinal tracks, and media are described, followed by a detailed comparison with the D-1 format, highlighting important differences. Emphasis is placed on how the composite format meets the needs of the user who records and distributes video in composite form.
Experimental measurement of the effective dielectric in the hydrophobic core of a protein (1997)

The dielectric inside a protein is a key physical determinant of the magnitude of electrostatic interactions in proteins. We have measured this dielectric phenomenologically, in terms of the dielectric that needs to be used with the Born equation in order to reproduce the observed pKa shifts induced by burial of an ionizable group in the hydrophobic core of a protein. Mutants of staphylococcal nuclease with a buried lysine residue at position 66 were engineered for this purpose. The pKa values of buried lysines were measured by difference potentiometry. The extent of coupling between the pKa and the global stability of the protein was evaluated by measuring pKa values in hyperstable forms of nuclease engineered to be 3.3 or 6.5 kcal mol-1 more stable than the wild type. The crystallographic structure of one mutant was determined to describe the environment of the buried lysine. The dielectrics that were measured range from 10 to 12. Published pKa values of buried ionizable residues in other proteins were analyzed in a similar fashion and the dielectrics obtained from these values are consistent with the ones measured in nuclease. These results argue strongly against the prevalent use of dielectrics of 4 or lower to describe the dielectric effect inside a protein in structure-based calculations of electrostatic energies with continuum dielectric models.
The<sup>10</sup>B(<i>n</i>,α<sub>0</sub>)/<sup>10</sup>B(<i>n</i>,α<sub>1</sub>γ) Branching Ratio (2007)

The 10B(n,α0)/10B(n,α1γ) branching ratio has been measured at the Geel linear accelerator based time-of-flight spectrometer in the incident neutron energy range from 0.1 keV up to 2 MeV. A twin Frisch-grid ionization chamber has been used with two very thin 10B samples mounted back-to-back on the common cathode. This type of ionization chamber made it possible to measure both the energy and the angular distribution of the emitted reaction products (alpha particles and 7Li nuclei) with a clear separation of both reaction channels: emission to the ground state (α0) and first excited state (α1). The branching ratio 10B(n,α0)/10B(n,α1γ) was found to be in good agreement with the ENDF/B-VI evaluation up to ˜1 MeV incident neutron energy. At higher energies (>1 MeV), a clear deviation is observed. The present branching ratio data have been entered into the ongoing International Atomic Energy Agency Coordinated Research Project on “Improvement of the Standard Cross Sections for Light Elements.” A preliminary R-matrix calculation reproduces the measured branching ratio in the whole energy range up to ˜2 MeV.
Synthesis of 2,3-dihydro-1H-phenothiazin-4(10H)-ones (1975)

S. Miyano, N. Abe and K. Sumoto, J. Chem. Soc., Chem. Commun., 1975, 760a DOI: 10.1039/C3975000760A
Structures Related to Morphine. XXVIII.<sup>1</sup> Alternative Syntheses of α- and β-2,9-Dimethyl-2'-hydroxy-5-propyl-6,7-benzomorphan (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructures Related to Morphine. XXVIII.1 Alternative Syntheses of α- and β-2,9-Dimethyl-2'-hydroxy-5-propyl-6,7-benzomorphanColin F. Chignell, J. Harrison Ager, and Everette L. MayCite this: J. Med. Chem. 1965, 8, 2, 235–238Publication Date (Print):March 1, 1965Publication History Published online1 May 2002Published inissue 1 March 1965https://doi.org/10.1021/jm00326a020RIGHTS & PERMISSIONSArticle Views68Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (564 KB) Get e-Alerts Get e-Alerts
ANTI-HIV ACTIVITY OF NOVEL PHOSPHONATE DERIVATIVES OF AZT, d4T, AND ddA (2001)

Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T and ddA. For d4T phosphonate derivatives the most active was 2',3'-Dideoxy-2',3'-didehydrothymidine 5'-isopropylphosphite and among the AZT phosphonate derivatives highest activity was shown by 2',3'-Dideoxy-3'-azidothymidine 5'-cyclohexylphosphite.
High-performance fluidic adaptive lenses (2004)

High-performance fluidic lenses with an adjustable focal length spanning a very wide range (30 mm to infinite) are demonstrated. We show that the focal length, F-number, and numerical aperture can be dynamically controlled by changing the shape of the fluidic adaptive lens without moving the lens position mechanically. The shortest focal length demonstrated is less than 30 mm for a 20-mm lens aperture. The fluidic adaptive lens has a nearly perfect spherical profile and shows a resolution better than 40 line pairs/mm in a plano-convex structure and 57 line pairs/mm in a biconvex structure.
Five-Year Outcomes From the Randomized, Phase III Trials CheckMate 017 and 057: Nivolumab Versus Docetaxel in Previously Treated Non–Small-Cell Lung Cancer (2021)

At 5 years, nivolumab continued to demonstrate a survival benefit versus docetaxel, exhibiting a five-fold increase in OS rate, with no new safety signals. These data represent the first report of 5-year outcomes from randomized phase III trials of a programmed death-1 inhibitor in previously treated, advanced NSCLC.
Glass of high refractive index for optics and optical fiber (1997)

Halide-chalcogenide glasses whose properties make them suitable for applications in modern optics and optical fiber technique are investigated. The object of examination were oxygen-free glasses in the Sb2Se3-BaCl2-PbCl2 system. Because of the unconventional method of obtaining these glasses (great difficulties connected with passing into the glassy state) a special method of synthesizing these glasses is developed. Their characteristic temperatures and thermal stabilities are determined. Structural investigations using IR spectroscopy are carried out and the phase composition following the crystallization of the glasses is established by x-ray examination. Certain properties of the glasses are investigated, giving special consideration to the optical properties (refractive index and transmission in the far-IR range). The investigation results reveal the possibility of producing stable glasses, a few millimeters thick, using a special method of synthesis. The absorption bands in the IR spectra of the examined glasses are attributed to the symmetric and asymmetric vibrations of the Sb-Se-Sb bridge. The transmission range of the obtained glasses falls within the limit 0.65 to 50 ?m, at the level of 38 to 60%, and the refractive index is n > 2.5. Material of such properties offers the possibility to obtain optical fibers of very high numerical aperture and special applications are possible because of a wide transmission range.
High B. T. U. Gas (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh B. T. U. GasG. C. WilliamsCite this: Ind. Eng. Chem. 1960, 52, 7, 575–576Publication Date (Print):July 1, 1960Publication History Published online1 May 2002Published inissue 1 July 1960https://pubs.acs.org/doi/10.1021/ie50607a023https://doi.org/10.1021/ie50607a023research-articleACS PublicationsRequest reuse permissionsArticle Views34Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Utilization of Modified NFL Combine Testing to Identify Functional Deficits in Athletes Following ACL Reconstruction (2011)

These findings indicate that, while unilateral deficits are present in individuals following ACL reconstruction, they may not be evident during bipedal performance or during modified versions of double-limb performance activities. Isolation of the involved limb with unilateral hopping tasks should be used to identify deficits in performance.
A Comparison of Oral Ketorolac and Hydrocodone-Acetaminophen for Analgesia After Ambulatory Surgery (1997)

This multicenter study compared the analgesic efficacy and side effects of ketorolac and hydrocodone-acetaminophen when administered orally after ambulatory arthroscopic or laparoscopic tubal ligation procedures. After awakening from general anesthesia, 252 patients experiencing moderate or severe postoperative pain were randomly assigned to receive one of three analgesic treatments according to a placebocontrolled, double-blind protocol. Group 1 (n = 83) received oral ketorolac 10 mg every 6 h for up to 3 days, Group 2 (n = 82) received hydrocodone 7.5 mg plus acetaminophen 750 mg every 6 h for up to 3 days, and Group 3 (n = 87) received placebo capsules followed by ketorolac 10 mg every 6 h for up to 3 days. Severity of pain was recorded using a 4-point categorical score and visual analog scale (VAS) at 0.5 h and subsequently at hourly intervals for 6 h, as well as daily for up to 3 days. Pain relief was recorded using a 5-point categorical scale at the same time points. In the patients undergoing arthroscopic surgery, both ketorolac and hydromorphone-acetaminophen provided superior pain relief compared with the placebo. Although the categorical summed pain intensity difference (SPID), VASSPID, and total pain relief scores were higher in the ketorolac group compared with the hydrocodone-acetaminophen group, the differences were not statistically significant. In the patients undergoing laparoscopic tubal ligation surgery, the three treatment groups displayed similar responses to the study medications. However, the ketorolac group scored higher in terms of overall tolerability than the hydrocodone-acetaminophen group. In conclusion, there was no difference in the efficacy between oral ketorolac and hydrocodone-acetaminophen combination in controlling pain after outpatient arthroscopic surgery procedures. Neither oral analgesic proved to be very effective after laparoscopic tubal ligation. (Anesth Analg 1997;85:37-43)
Prion-inducing domain 2–114 of yeast Sup35 protein transforms <i>in vitro</i> into amyloid-like filaments (1997)

The yeast non-Mendelian genetic factor [PSI], which enhances the efficiency of tRNA-mediated nonsense suppression in Saccharomyces cerevisiae, is thought to be an abnormal cellular isoform of the Sup35 protein. Genetic studies have established that the N-terminal part of the Sup35 protein is sufficient for the genesis as well as the maintenance of [PSI]. Here we demonstrate that the N-terminal polypeptide fragment consisting of residues 2-114 of Sup35p, Sup35pN, spontaneously aggregates to form thin filaments in vitro. The filaments show a beta-sheet-type circular dichroism spectrum, exhibit increased protease resistance, and show amyloid-like optical properties. It is further shown that filament growth in freshly prepared Sup35pN solutions can be induced by seeding with a dilute suspension of preformed filaments. These results suggest that the abnormal cellular isoform of Sup35p is an amyloid-like aggregate and further indicate that seeding might be responsible for the maintenance of the [PSI] element in vivo.
Laser surface interactions of high-T(sub c) superconductors (1990)

During the past two years, one of the most exciting research fields in science has been the study of the newly discovered high-T(sub c) metal oxide superconductors. Although many theoretical models were proposed, there is no general agreement on any theory to explain these materials. One of the peculiar features of these high-T(sub c) materials is the noninteger number of oxygen atoms. The oxygen content is extremely critical to the superconductive properties. Take YBa2Cu3O(7-x) as an example. Its superconductive properties disappear whenever x is larger than 0.5. The existence of Cu(+ 3) was considered to account for x less than 0.5. However, results from mass spectroscopy of laser desorbed species indicate that significant quantities of oxygen molecules are trapped in the bulk of these high-T(sub c) superconductors. It appears that these trapped oxygen molecules may play key roles in superconductive properties. Preparation of superconductive thin films are considered very important for the applications of these new superconductors for the electronics industry. Fluorescence spectra and ion spectra following laser ablation of high-temperature superconductors were obtained. A real time monitor for preparation of superconductive thin films can possibly be developed.
Development of an Indoor Navigation System Using NFC Technology (2011)

Existing indoor navigation systems face with many different technical and usability problems. In this paper we present a Near Field Communication (NFC) based indoor navigation system called NFC Internal in order to eliminate the current indoor navigation problems. NFC Internal enables an easy data transfer for indoor navigation systems just by touching tags spread over a building or a complex. The proposed system has several benefits and has potential to increase the usability of these systems. We discuss the system requirements and explain the phases of NFC Internal through use cases.