Hypertension Associated with Endothelin-Secreting Malignant Hemangioendothelioma (1991)

Brief Reports1 February 1991Hypertension Associated with Endothelin-Secreting Malignant HemangioendotheliomaKoji Yokokawa, MD, Hideki Tahara, MD, Masakazu Kohno, MD, Koh-ichi Murakawa, MD, Kenichi Yasunari, MD, Koichi Nakagawa, MD, Toshio Hamada, MD, Shuzo Otani, MD, Masashi Yanagisawa, MD, Tadanao Takeda, MDKoji Yokokawa, MD, Hideki Tahara, MD, Masakazu Kohno, MD, Koh-ichi Murakawa, MD, Kenichi Yasunari, MD, Koichi Nakagawa, MD, Toshio Hamada, MD, Shuzo Otani, MD, Masashi Yanagisawa, MD, Tadanao Takeda, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-3-213 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEndothelin-1, a potent vasoconstrictor peptide that has recently been isolated from the supernatant of cultured porcine aortic endothelial cells (1), is involved in some vascular disorders (2). Malignant hemangioendothelioma, a rare malignant vascular neoplasm, is characterized by intravascular proliferation of atypical endothelium. Patients with malignant hemangioendothelioma usually die with metastases to the lungs and brain or with vascular involvement in the brain or coronary arteries (3). We measured plasma levels of endothelin-1 in two patients with malignant hemangioendothelioma of the scalp before and after surgical excision.Materials and MethodsEndothelin-1 was extracted from EDTA-plasma or prepared tissue samples (4) through...References1. YanagisawaKuriharaKimura MHS. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411-5. CrossrefMedlineGoogle Scholar2. MiyauchiYanagisawaTomizawa TMT. Increased plasma concentration of endothelin-1 and big endothelin-1 in acute myocardial infarction [Letter]. Lancet. 1989;2:53-4. CrossrefMedlineGoogle Scholar3. PetitoGottliebDoughertyPetito CGJF. Neoplasmic angioendotheliosis: ultrastructural study and review of the literature. Ann Neurol. 1978;3:393-9. CrossrefMedlineGoogle Scholar4. NakaoSugawaraMorii KAN. Radioimmunoassay for α-human and rat atrial natriuretic polypeptide. Biochem Biophys Res Commun. 1984;124:815-21. CrossrefMedlineGoogle Scholar5. KohnoMurakawaYasunari MKK. Prolonged blood pressure elevation after endothelin administration in bilaterally nephrectomized rats. Metabolism. 1989;38:712-3. CrossrefMedlineGoogle Scholar6. KohnoYasunariMurakawa MKM. Plasma immunoreactive endothelin in essential hypertension. Am J Med. 1990;88:614-8. CrossrefMedlineGoogle Scholar7. ChomczynskiSacchi PN. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-9. CrossrefMedlineGoogle Scholar8. VierhapperWagnerNowotnyWaldhausl HOPW. Effect of endothelin-1 in man. Circulation. 1990;81:1415-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Osaka City University Medical School, Osaka, Japan; and the Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCirculating Levels of Endothelin-1 and Big Endothelin-1 in Patients with Essential HypertensionThe Causal Relationship between Endothelin-1 and Hypertension: Focusing on Endothelial Dysfunction, Arterial Stiffness, Vascular Remodeling, and Blood Pressure RegulationThe endothelin system as target for therapeutic interventions in cardiovascular and renal diseaseEndothelin: 30 Years From Discovery to TherapyEndothelial dysfunction and vascular disease - a 30th anniversary updateEndothelin Antagonism and Hypertension: An Evolving TargetCurrent state of endothelin receptor antagonism in hypertension and pulmonary hypertensionTreatment of Hypertension in Older Persons: What Is the Evidence?Endothelin antagonists in hypertension and kidney diseaseAn assessment of the relationship between excess fluoride intake from drinking water and essential hypertension in adults residing in fluoride endemic areasEndothelin Receptor Antagonists in Cardiovascular Medicine: Challenges and OpportunitiesEndothelinTherapeutic potential of endothelin receptor antagonists for chronic proteinuric renal disease in humansEndothelin—Biology and diseaseHypertension: Is It Overtreated in the Elderly?Hormones of the Cardiovascular SystemEndothelin: 20 years from discovery to therapyThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin.Kinins and EndothelinThe genetic basis for altered blood vessel function in disease: large artery stiffeningEndothelin in HypertensionThe potential of endothelin antagonism as a therapeutic approachEndothelin-dependent modulation of vasoconstrictor action in the coronary circulation in early salt-induced experimental hypertensionNew therapeutics that antagonize endothelin: promises and frustrationsEvidence for microvascular dysfunction after prenatal dexamethasone at 0.7, 0.75, and 0.8 gestation in sheepParticipation of renal and circulating endothelin in salt-sensitive essential hypertensionVascular Protective Effects of Angiotensin Converting Enzyme Inhibitors and their Relation to Clinical EventsRole of endogenous endothelin on coronary flow in health and diseaseEndothelin gene variants and aortic and cardiac structure in never-treated hypertensivesEndothelin as a Therapeutic Target in the Treatment of Cardiovascular DiseaseEndothelin System: The Double-Edged Sword in Health and DiseaseEndokrine HypertonieEndothelins and Endothelin Receptor AntagonistsTissue Endothelin-Converting Enzyme Activity Correlates With Cardiovascular Risk Factors in Coronary Artery DiseaseThe renoprotective potential of endothelin receptor antagonistsDysfunctional Renal Nitric Oxide Synthase as a Determinant of Salt-Sensitive HypertensionEndothelin antagonists in renal diseasePolymyalgia rheumatica as a manifestation of a large hepatic cavernous hemangiomaEndothelial Modulation of Vascular TonePlasma Endothelin Concentrations in HypertensionA Dopamine-Secreting PheochromocytomaEndothelin receptor antagonists: novel agents for the treatment of hypertension?Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertensionAngiotensin Converting Enzyme Inhibitors and Vascular Protection in HypertensionAngiotensin Converting Enzyme Inhibitors and Vascular Protection in HypertensionPerioperative Plasma Endothelin-1 and Big Endothelin-1 Concentrations in Elderly Patients Undergoing Major Surgical ProceduresENDOTHELIN-1 AS A MEDIATOR IN CARDIOVASCULAR DISEASEEndothelin receptor antagonists influence cardiovascular morphology in uremic ratsEndothelin and its antagonists in hypertension: Can we foresee the future?Endothelin in cardiovascular control: The role of endothelin antagonistsEndothelin antagonistsEndothelin-1 receptor antagonism does not influence myocardial function in hypertensive dogsA role for endothelin in the pathogenesis of hypertension: Fact or fiction?Endothelin as a regulator of cardiovascular function in health and diseaseHandgrip Increases Endothelin-1 Secretion in Normotensive Young Male Offspring of Hypertensive Parents 11This study was supported by Grant 5/15/02/003 from the Ministero Università e Ricerca Scientifica e Tecnologica-Italia, Rome.Structure of Human Endothelin-2 Gene and Demonstration of Common Expression in Human Right Atrial TissueEndothelin‐secreting angiosarcoma occurring at the site of an arteriovenous fistula for haemodialysis in a renal transplant recipientEndothelin in Primate Pregnancy and an Experimental Preeclampsia-Like SyndromeEndothelial Dysfunction: Does It Matter? Is It Reversible?Endothelin in Human Cardiovascular Physiology and PathophysiologyEndothelin in Hypertension: A Role in Vascular Hypertrophy?The EndothelinsEndothelin in renal pathophysiology: From experimental to therapeutic applicationNeurohormonal factors in the pathogenesis of essential hypertensionInfantile Hemangioendothelioma of the Liver in a NeonateThe Endothelin PeptidesEndothelins in breast cancerEndothelin and endothelin antagonists: Potential role in cardiovascular and renal diseaseThe endothelin system and its potential as a therapeutic target in cardiovascular diseasePlasma Endothelin-1 Levels in Patients with Aldosterone-Producing Adenoma and PheochromocytomaThe role of nitric oxide and other endothelium-derived vasoactive substances in vascular diseaseIdentification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostatePlasma endothelin-1 levels in patients with systemic sclerosis: influence of pulmonary or systemic arterial hypertension.EndothelinsEndothelin: Potential Role in Hypertension and Vascular HypertrophyInhibition of Endothelin Production by Adrenomedullin in Vascular Smooth Muscle CellsEndothelin Production in Cultured Mesangial Cells of Spontaneously Hypertensive RatsENDOTHELIN-1 AND THE REGULATION OF VASCULAR TONENitric oxide and endothelin in pathophysiological settingsEndothelin Production in Cultured Mesangial Cells of Spontaneously Hypertensive RatsCharacterization and Functional Analysis of the Rat Endothelin-1 PromoterEndothelin and Endothelin Antagonists: Pharmacology and Clinical ImplicationsEndothelin Receptor Antagonists as New Tools to Inhibit Endothelin induced Vasoconstriction in Humans: Comparison with Calcium Channel BlockersEndothelin in Hypertension and Vascular Hypertrophy: Experimental StudiesEndothelin Receptor AntagonismPatent Update: Cardiovascular & Renal: Endothelin receptor antagonistsEndothelial Regulation of Vascular ToneThe solution structure of sarafotoxin-c. Implications for ligand recognition by endothelin receptors.Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1Major Issues in Geriatrics over the Last Five YearsRole of endothelin in hypertensionHeparin inhibits endothelin-1 production in cultured rat mesangial cellsEndothelioma Cells Express and Secrete Endothelin-1 and Inhibit Platelet Aggregation through Nitric Oxide FormationEndothelins in the Kidney: Physiology and PathophysiologyThiol and hydroxamic acid containing inhibitors of endothelin converting enzymeEndothelins as regulators of growth and function in endocrine tissuesInsulin modulates circulating endothelin-1 levels in humansEpithelioid angiosarcoma of the intestinal tract with endothelin-1-like immunoreactivityIs endothelin involved in the pathogenesis of hypertension?Potential role of endothelin in hypertension. Controversy on endothelin in hypertension.Sarafotoxins and endothelins: evolution, structure and functionL'endothéline: vasoconstricteur des années 1990?Essential hypertension: a renal disease? A review and update of the evidence.Paraendocrine SyndromesEndothelin as a neuropeptide. Cardiovascular effects in the brainstem of normotensive rats.Endothelial regulation of vascular tone.Physiology and pharmacology of endothelinsGenetic regulation of endothelin-1 in vascular endothelial cellsEndothelin-1 stimulates the Na+/H+ and Na+/HCO3- transporters in rabbit renal cortexSalt-dependency of endothelin-induced, chronic hypertension in conscious rats.Captopril prevents chronic hypertension produced by infusion of endothelin-1 in rats.C-type natriuretic peptide inhibits thrombin- and angiotensin II-stimulated endothelin release via cyclic guanosine 3',5'-monophosphate.EndothelinsEndothelin Peptides: Biological Activities, Cellular Signalling and Clinical SignificanceSouthwestern Internal Medicine Conference: The Endothelium—A Key Regulator of Vascular ToneMolecular and cellular mechanism of endothelin regulation. Implications for vascular function.Biological actions and pathophysiologic significance of endothelin in the kidneyEndothelin-dependent hypertensionEndothelin 1 February 1991Volume 114, Issue 3Page: 213-215KeywordsBiochemistryBlood plasmaBrainCoronary arteriesDermatologyEndothelial cellsEndotheliumHypertensionLungsPharmacology Issue Published: 1 February 1991 PDF downloadLoading ...