gebhart/patrepeval huggingface dataset:
Methyl Jasmonate and Salicylic Acid Induced Oxidative Stress and Accumulation of Phenolics in Panax ginseng Bioreactor Root Suspension Cultures (2007)

To investigate the enzyme variations responsible for the synthesis of phenolics, 40 day-old adventitious roots of Panax ginseng were treated with 200 microM methyl jasmonate (MJ) or salicylic acid (SA) in a 5 L bioreactor suspension culture (working volume 4 L). Both treatments caused an increase in the carbonyl and hydrogen peroxide (H2O2) contents, although the levels were lower in SA treated roots. Total phenolic, flavonoid, ascorbic acid, non-protein thiol (NPSH) and cysteine contents and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical reducing activity were increased by MJ and SA. Fresh weight (FW) and dry weight (DW) decreased significantly after 9 days of exposure to SA and MJ. The highest total phenolics (62%), DPPH activity (40%), flavonoids (88%), ascorbic acid (55%), NPSH (33%), and cysteine (62%) contents compared to control were obtained after 9 days in SA treated roots. The activities of glucose 6-phosphate dehydrogenase, phenylalanine ammonia lyase, substrate specific peroxidases (caffeic acid peroxidase, quercetin peroxidase and ferulic acid peroxidase) were higher in MJ treated roots than the SA treated ones. Increased shikimate dehydrogenase, chlorogenic acid peroxidase and beta-glucosidase activities and proline content were observed in SA treated roots than in MJ ones. Cinnamyl alcohol dehydrogenase activity remained unaffected by both MJ and SA. These results strongly indicate that MJ and SA induce the accumulation of phenolic compounds in ginseng root by altering the phenolic synthesis enzymes.
A Forbidden Rearrangement (2003)

[reaction: see text] A barrelene derivative fragments to afford benzene and trappable 1,2,3-tricyanocyclopropene. The barrelene anion fragments more easily to liberate benzene and the 1,2,3-tricyanocyclopropenyl anion, which is not trappable or stable in solution. However, the major thermal product from the barrelene anion is a rearranged allyl anion that is formed by disrotatory cleavage of the cyclopropyl ring, a formally Woodward-Hoffmann-forbidden process. Several proposals are offered to rationalize this forbidden rearrangement.
PREPARATION OF POROUS THORIA BY INCORPORATION OF CARBON IN SOLS. (1968)

i t s i s a .na any wm asfinpi on 6.h@l6 of %b hrmanmhsibfi: A. hk un7 w m n W w rrpc*r*RtaMm, e*9(;ewd ?a impll*d, wSth rargacl t e fh.aocwucy, wrnahtw#,s~, w u r w b f ~c s d t h OC.mmPElrm e m m i d in this rep&, er t b i tth.u u af rsy SnbMlm, rppem*ws, nrthd, or p w r s s dpaelawd in thls rwwt may M Minga wivet.lp
Correlation between fibrinogen binding to human platelets and platelet aggregability (1980)

Fibrinogen is essential for aggregating platelets with adenosine diphosphate (ADP) and was recently shown to bind to platelets stimulated with ADP. The present work confirms the specific and saturable nature of the platelet-fibrinogen interaction. Binding of 125iodine-labeled fibrinogen to human gel-filtered platelts was maximal at 1 min, and the receptors were saturated when the fibrinogen concentration in the suspending medium approached 0.8 mg/ml. Assuming that one fibrinogen molecule interacts with a single receptor, experiments with 9 normal donors revealed the presence of 12,896 +/- 2456 receptors per platelet. Much of the bound material dissociated from platelets after incubation with apyrase or EDTA. Binding was markedly inhibited at pH 6.5, in the presence of EDTA, and with platelets from 3 thrombasthenic patients but not with those from a patient with the Bernard-Soulier syndrome. Fibrinogen binding was also virtually absent with platelets that had been incubated with EDTA for 8 min at 37 degrees C and pH 7.8. These platelets could not aggregate when mixed with ADP and adequate CaCl2 and fibrinogen, although they could still change their shape. Thus, ADP-induced binding of fibrinogen correlates with platelet aggregability.
Kinetic Measurements on Single-Molecule Disulfide Bond Cleavage (2011)

We use single-molecule force clamp spectroscopy (SMFCS) to explore the reactivity of tris(2-carboxyethyl)phosphine (TCEP), 1, 4-dl-dithiothreitol (DTT) and hydrosulfide anion (HS(-)) on disulfide bonds within a mechanically stretched polypeptide. The single-bond level bimolecular nucleophilic substitution (S(N)2) events are recorded at a series of precisely controlled temperatures so that the Arrhenius kinetic parameters, that is, the height of the activation energy barrier (E(a)) and the attempting frequency (A) of the chemical reactions, can be determined. The values of A are typically at the order of 10(7) M(-1) s(-1), which is far lower than that predicted by the transition-state theory, in which A is given by k(B)T/h and around 10(12) M(-1) s(-1) at room temperature. Furthermore, E(a) is derived to be 30-40 kJ/mol, which can be lowered by ∼6-8% with every 100 pN mechanical force applied. The correlation of the A and E(a) with the molecular structures reveals that the relative magnitude of these two parameters cannot be simply judged from the size of the molecule or the nucleophilicity of the attacking atom. The comparison of the influences on the reaction rate induced by force and temperature indicates an equivalent accelerating effect by every 50 pN or 10 K increment, giving for the first time the relationship between mechanical and thermal effects on a single-molecule S(N)2 chemical reaction.
Privacy-Preserving Outsourced Feature Extractions in the Cloud: A Survey (2017)

Large-scale multimedia data generated in our daily life have increasingly motivated companies and researchers to discover valuable knowledge and hidden information by employing machine learning techniques. It is well known that this is an inherently time consuming job to deal with massive multimedia data locally. Thanks to the rapid development of cloud computing, the data owner is highly motivated to outsource these multimedia data, along with the computationally intensive processing tasks, to the cloud by leveraging its abundant resources for cost saving and flexibility. However, due to different trust domains, privacy issues also arise from the exposure to the cloud of private information that is intrinsically embedded in the outsourced data. As a key preprocessing step in machine learning, feature extractions have been extensively studied in the framework of privacy-preserving outsourced computation for their effectiveness in removing irrelevant and redundant data, and increasing learning accuracy. In this article, we provide a comprehensive survey of privacy-preserving outsourcing computation of various feature extraction algorithms in recent literature. Following a brief overview of each scheme, we present the primary technical hurdles needed to be addressed and then compare the state-of-theart solutions in terms of security and effectiveness. Then we discuss several promising future research directions with a focus on privacy-preserving machine learning in the cloud.
Block Adaptive Beamforming via Parallel Projection Method (2005)

This paper addresses a simple, and yet effective approach to the design of block adaptive beamformers via parallel projection method (PPM), which is an extension of the classic projection onto convex set (POCS) method to inconsistent sets scenarios. The proposed approach begins with the construction of the convex constraint sets which the weight vector of the adaptive beamformer lies in. The convex sets are judiciously chosen to force the weights to possess some desirable properties or to meet some prescribed rules. Based on the minimum variance criterion and a fixed gain at the look direction, two constraint sets including the minimum variance constraint set and the gain constraint set are considered. For every input block of data, the weights of the proposed beamformer can then be determined by iteratively projecting the weight vector onto these convex sets until it converges. Furnished simulations show that the proposed beamformer provides superior performance compared with previous works in various scenarios but yet in general with lower computational overhead.
Synthesis and characteristics of a novel, high-nitrogen, heat-resistant, insensitive material (NOG<sub>2</sub>Tz) (2011)

The novel, high-nitrogen, energetic compound, 3,6-bis(3-nitro-1,2,4-oxadiazole-5-guanyl)-1,2,4,5-tetrazine (NOG2Tz, 8, N 53.08%), was synthesised and fully characterised. Thermal decomposition kinetics and several thermodynamic parameters were obtained under non-isothermal conditions by DSC. NOG2Tz exhibits a high density and was calculated to have favourable detonation properties. It is thermally stable (Tdec. 328 °C) and remarkably insensitive to impact.
Watson: design space boundary exploration and model generation for analog and RF IC design (2003)

A new method is described which gives the designer access to the design space boundaries of a circuit topology, all with transistor-level accuracy. Using multiobjective genetic optimization, the hypersurface of Pareto-optimal design points is calculated. Tradeoff analysis of competing performances at the design space boundaries is made possible by the application of multivariate regression techniques. This new methodology is illustrated with the presentation of the design space for two different types of circuits: a Miller-compensated operational transconductance amplifier and an LC-tank voltage-controlled oscillator.
UAV Task Assignment with Timing Constraints via Mixed-Integer Linear Programming (2004)

Abstract : The optimal timing of air-to-ground tasks is undertaken. Specifically, a scenario where multiple air vehicles are required to prosecute geographically dispersed targets is considered. The vehicles must perform multiple tasks on each target. The targets must be found, classified, attacked, and verified as destroyed. The optimal performance of these tasks requires cooperation amongst the vehicles such that critical timing constraints are satisfied. In this paper, an optimal task assignment and timing algorithm is developed, using a mixed integer linear program, or MILP, formulation. MILP can be used to assign all tasks to the vehicles in an optimal manner, including variable arrival times, for groups of air vehicles with coupled tasks involving timing and task order constraints. When the air vehicles have sufficient endurance, the existence of a solution is guaranteed.
Ozonization and Oxidation of Stearolic Acid to 9, 10-Diketostearic Acid (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOzonization and Oxidation of Stearolic Acid to 9, 10-Diketostearic AcidN. A. Khan and Melvin S. NewmanCite this: J. Org. Chem. 1952, 17, 7, 1063–1065Publication Date (Print):July 1, 1952Publication History Published online1 May 2002Published inissue 1 July 1952https://pubs.acs.org/doi/10.1021/jo50007a024https://doi.org/10.1021/jo50007a024research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Story Structure and Development: A Guide for Animators, VFX Artists, Game Designers, and Virtual Reality (2017)

Professor Craig Caldwell’s Story Structure and Development offers a clear approach to the essentials of story. It lays out the fundamental elements, principles, and structure for animators, designers, and artists so they can incorporate these concepts in their work. As a practical guide it includes extensive insights and advice from industry professionals. Readers will learn the universal patterns of story and narrative used in today’s movies, animation, games, and VR. With over 200 colorful images, this book has been designed for visual learners, and is organized to provide access to story concepts for the screen media professional and student. Readers will discover the story fundamentals referred to by every director and producer when they say "It’s all about story". (source : éditeur)
G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells. (1997)

UCN-01 (7-hydroxyl-staurosporine) was originally isolated as a Ca2+- and phospholipid-dependent protein kinase C selective inhibitor and now is being developed as an anticancer agent. Results from our and other laboratories have suggested that UCN-01 induces preferential G1-phase accumulation in several human tumor cell lines tested. To elucidate this mechanism, we examined the effects of UCN-01 on several cell cycle-regulatory proteins critical for G1-S-phase transition in p53-mutated human epidermoid carcinoma A431 cells. After 24 h exposure at around 50% growth-inhibitory concentrations (IC50s), 260 and 520 nM, UCN-01 induced the accumulation of pRb (the dephosphorylated retinoblastoma protein form). The protein expression of cyclin A but not cyclin E was markedly reduced and that of cyclin D1 was partially reduced under the same condition. UCN-01 also showed the concentration-dependent inhibitions of the activity of cyclin-dependent kinase 2 (CDK2) using histone H1 and pRb as substrates in vitro (IC50, 530 and 640 nM, respectively). In addition, CDK2 activities of the cells pretreated with UCN-01 for 24 h at 260 and 520 nM were markedly inhibited, giving IC50s of far less than 260 nM. When the same cell lysates were analyzed by Western blotting for CDK2, the lower band (e.g., active and phosphorylated CDK2) was remarkably reduced, in accordance with the reduced activity. Furthermore, UCN-01 induced the expression of the CDK inhibitor p21 protein and its complex formation with CDK2 after 24 h exposure at 260 and 520 nM, whereas the expression level was very low or undetectable in untreated or DNA-damaged cells. The increase of p21 mRNA levels was also induced under the same condition. UCN-01 further increased luciferase activities in A431 cells transiently transfected with p21 promoter-luciferase reporter plasmid after 24 h exposure at 260 and 520 nM. UCN-01 also increased the expression of the CDK inhibitor p27 protein after 24 h exposure at 260 and 520 nM. These results suggest that G1-phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitors p21 and p27.
Expression of Chemokines in GVHD Target Organs Is Influenced by Conditioning and Genetic Factors and Amplified by GVHR (2006)

Graft-versus-host disease (GVHD) is the most significant clinical problem that arises after allogeneic hematopoietic cell transplantation. Because chemokines induced by proinflammatory conditioning treatment may promote T-cell migration into GVHD target tissues, we addressed the influence of conditioning on chemokine expression in GVHD target organs. Our results showed that (1) conditioning leads to rapid and transient chemokine upregulation in GVHD target tissues before the time of GVHD-associated T-cell infiltration; (2) conditioning intensity and mouse strain influence chemokine expression in GVHD target organs; and (3) compared with syngeneic bone marrow transplantation, allogeneic bone marrow transplantation led to marked amplification of chemokine expression in GVHD target organs after myeloablative conditioning. This is also reflected by chemokine protein expression that is measured in the serum and colon. Intestines showed the greatest sensitivity to conditioning intensity, and chemokines affecting T-helper type 1 cells (eg, interferon gamma-inducible protein 10 [CXCL10]) were most strongly expressed there after conditioning and during GVHD. However, severity of GVHD was not significantly different between recipients of CXCR3+/+ or CXCR3-/- splenocytes, indicating that this chemokine pathway does not play a critical role. In summary, our data show that conditioning and recipient strain influence chemokine expression in GVHD target organs and that GVH alloreactivity markedly amplifies this expression, thus contributing to the inflammatory cascade associated with tissue GVHD.
Rehabilitation Interventions for Unilateral Neglect after Stroke: A Systematic Review from 1997 through 2012 (2013)

A systematic review of the effectiveness of rehabilitation for persons with unilateral neglect (UN) after stroke was conducted by searching the computerized databases from 1997 through 2012. Randomized controlled trials (RCTs) of neglect treatment strategies for stroke patients which used the Behavioral Inattention Test (BIT) as the primary outcome measure were eligible for inclusion. Out of 201 studies initially identified, 12 RCTs covering 277 participants were selected for analysis. All had the same weakness of low power with smaller samples and limitation in the blinding of the design. Prism Adaptation (PA) was the most commonly used intervention while continuous Theta-burst stimulation (cTBS) appeared to be a new approach. Meta-analysis showed that for immediate effects, the BIT conventional subscore had a significant and large mean effect size (ES = 0.76; 95% CI 0.28-1.23; p = 0.002) whereas the BIT total score showed a modestly significant mean ES (ES = 0.55; 95% CI 0.16-0.94; p = 0.006). No significant mean ES in sensitivity analysis was found for long-lasting effects across all BIT outcomes. PA appeared to be the most effective intervention based on the results of pooled analysis. More rigorous studies should be done on repetitive transcranial magnetic stimulation (rTMS) before it can be concluded that it is a promising treatment for UN.
Die Nitroparaffine als Lösungsmittel für technisch Anstriche (1956)

Abstract Ausführliche Besprechung der Eigenschaften, möglichen Anwendungen und Vorteile der Nitroparaffine, einer verhältnismäßig neuen Gruppe von Lösungsmitteln, die jetzt in großen Mengen erhältlich sind.
A Single‐Framework Synthetic Antibody Library Containing a Combination of Canonical and Variable Complementarity‐Determining Regions (2017)

Synthetic antibody libraries have been used to generate antibodies with favorable biophysical and pharmacological properties. Here, we describe the design, construction, and validation of a phage-displayed antigen-binding fragment (Fab) library built on a modified trastuzumab framework with four fixed and two diversified complementarity-determining regions (CDRs). CDRs L1, L2, H1, and H2 were fixed to preserve the most commonly observed "canonical" CDR conformation preferred by the modified trastuzumab Fab framework. The library diversity was engineered within CDRs L3 and H3 by use of custom-designed trinucleotide phosphoramidite mixes and biased towards human antibody CDR sequences. The library contained ≈7.6 billion unique Fabs, and >95 % of the library correctly encoded both diversified CDR sequences. We used this library to conduct selections against the human epidermal growth factor receptor-3 extracellular domain (HER3-ECD) and compared the CDR diversity of the naïve library and the anti-HER3 selection pool by use of next-generation sequencing. The most commonly observed CDR combination isolated, named Her3-3, was overexpressed and purified in Fab and immunoglobulin G (IgG) formats. Fab HER3-3 bound to HER3-ECD with a K<sub>D</sub> value of 2.14 nm and recognized cell-surface HER3. Although HER3-3 IgG bound to cell-surface HER3, it did not inhibit the proliferation of HER3-positive cells. Near-infrared imaging showed that Fab HER3-3 selectively accumulated in a murine HER3-postive xenograft, thus providing a lead for the development of HER3 imaging probes.
Ca <sup>2+</sup> Sparks and Their Function in Human Cerebral Arteries (2002)

This study provides evidence for local Ca2+ signaling in human arterial myocytes and suggests that these events may play an important role in control of cerebral artery diameter in humans.
Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancer. (1994)

The enhancer of Moloney murine leukemia virus (Mo-MuLV) contains an array of transcriptional control elements that direct viral gene expression in diverse cell types. The murine transcription factor Ets-1 was shown to bind to the LVb and LVc elements of the enhancer by DNase I protection and methylation interference assays. Enhancers containing disrupted Ets-1 binding sites were tested in transient expression assays in the murine T-cell line EL4.E1; alterations in the LVb element affected constitutive enhancer activity, while mutation of either the LVb or LVc element disrupted phorbol ester-induced enhancer activity. Members of the ets gene family of proteins display similar DNA-binding properties; therefore, we speculated that ets proteins other than Ets-1 also might bind these elements. Crude nuclear extracts of EL4.E1 cells were assayed to identify the protein(s) that potentially functions at the LVb element. The predominant binding activity was not Ets-1 but rather two independent DNA-protein complexes that comigrated in mobility shift assays. UV cross-linking and denaturing gel electrophoresis sized the two DNA-binding species, which we denoted p55 and p100. Immunoprecipitation combined with UV cross-linking identified p55 as the alpha subunit of GA-binding protein. The DNA-binding properties of p100 and several ets proteins were compared. Similarities suggested that p100 is also an ETS domain protein, possibly Elf-1. This strategy could be used to identify other ETS domain proteins in crude nuclear extracts. These findings suggest multiple ETS domain proteins could regulate gene expression of Mo-MuLV.
Optimized Visualization Of Stereo Images On An Omap Platform With Integrated Parallax Barrier Auto-Stereoscopic Display (2009)

Publication in the conference proceedings of EUSIPCO, Glasgow, Scotland, 2009