gebhart/patrepeval huggingface dataset:
Soyasaponin VI, A New Maltol Conjugate from Alfalfa and Soybean (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSoyasaponin VI, A New Maltol Conjugate from Alfalfa and SoybeanGeorges Massiot, Catherine Lavaud, Mohamed Benkhaled, and Louisette Le Men-OlivierCite this: J. Nat. Prod. 1992, 55, 9, 1339–1342Publication Date (Print):September 1, 1992Publication History Published online1 July 2004Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/np50087a031https://doi.org/10.1021/np50087a031research-articleACS PublicationsRequest reuse permissionsArticle Views285Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integration of carbon sequestration into curing process of precast concrete (2010)

The feasibility of integrating carbon sequestration into the curing of precast concrete products was investigated. Research assessed the CO 2 uptake capacities of carbonation-cured concrete masonry units (CMU), concrete pavers, fibreglass-mesh reinforced cement board, cellulose-fibre board, and ladle slag fines. Three curing systems were used: (i) an open-inlet system using pressurized recovered CO 2 ; (ii) a closed system using pressurized flue gas with 14% CO 2 ; and (iii) a closed system using dilute CO 2 under atmospheric pressure. The amount of carbon dioxide that could be sequestered in the annual North American output of the various precast concrete products was estimated. The net efficiency was calculated accounting for CO 2 emissions penalty resulting from the capture, compression, and potential transport of the curing gases. Carbonation curing of the considered products could result in a net annual CO 2 sequestration in US and Canada of approximately 1.8 million tonnes if recovered CO 2 is used and one million tonnes if flue gas is used.
Evidence that a plasmid from a hyperthermophilic archaebacterium is relaxed at physiological temperatures (1992)

A plasmid of 3.45 kb (pGT5) was recently discovered in a strain of hyperthermophilic archaebacterium which was isolated from samples collected in a deep-sea hydrothermal vent. This strain (GE5) grows within a temperature range of 68 to 101.5 degrees C, and we show here that it contains a strong ATP-dependent reverse gyrase activity (positive DNA supercoiling). By comparison with eubacterial plasmids of known superhelical densities, we estimated the superhelical density of the archaebacterial plasmid pGT5 to be -0.026 at 25 degrees C. The equation which relates the change of the rotation angle of the DNA double helix with temperature was validated at 95 degrees C, the optimal growth temperature of the GE5 strain. Considering these new data, the superhelical density of plasmid pGT5 was calculated to be -0.006 at the physiological temperature of 95 degrees C, which is close to the relaxed state. This finding shows that the DNA topology of a plasmid isolated from a hyperthermophilic archaebacterium containing reverse gyrase activity is strikingly different from that of typical eubacterial plasmids.
UHF RFID shelf solution with cascaded reader antenna and positioning capability (2012)

Automatic goods inventory on the shelf is an important Ultra High Frequency (UHF) Radio Frequency Identification (RFID) application. Compared to other applications, it has some unique requirements: 1) Confined read region to avoid the cross reads to other tiers and shelves; 2) Positioning capability to know where along the shelf the tag is; 3) Low total system cost to support many shelves in the application. In this paper, an innovative UHF RFID solution is proposed for the RFID shelf. It contains two key technologies. First, the proposed near field (NF) shelf antenna in [1] is improved to provide the possibility to connect 5 cascaded antennas to one antenna port. It can save the system cost by reducing the number of needed readers. Second, a phase difference measurement based tag positioning method is proposed. To support different applications, it can provide both tier level and item level positioning for the goods on the shelf. Based on the measurement results, the proposed method can get the item level positioning accuracy with an average error of 4.16cm. It can also get 100% tier level positioning accuracy.
Dermal fibroblast culture as a model system for studies of fibrillin assembly and pathogenetic mechanisms: defects in distinct groups of individuals with Marfan's syndrome. (1996)

Most patients with Marfan's syndrome (> 95%) and 75% of patients with uncertain diagnosis can be classified into four groups (Aoyama et al, 1994, 1995) based on abnormal patterns of synthesis, intracellular transport, and/or matrix deposition of fibrillin-1 in fibroblast cultures. Herein we report a systematic study of fibrillin assembly in normal and Marfan's syndrome fibroblasts and correlations between pulse-chase, immunofluorescence, and immunoelectron microscopic data. Normal control fibroblasts were grown at confluent conditions from 2 to 10 days before passage and then maintained at hyperconfluent cell densities for an additional period of 1 to 6 days before assaying. Maximum deposition in the extracellular matrix of pulse-labeled fibrillin required at least 6 days of confluent and 4 to 5 days of hyperconfluent culture. This result is explained by immunofluorescence studies with fibrillin-1-specific antibodies, because 1 day after seeding cells at hyperconfluency, patches of regular immunostained structures were already present. Within these patches, fluorescence intensity and fibrillar material increased over 3 to 4 days, and after only 5 days, fibrillar networks extended throughout the culture. We propose that fibrillin-containing microfibrillar material is passaged together with the cells, newly synthesized fibrillin molecules are deposited onto preexisting microfibrillar assemblies, and several additional days of culture at high cell density are necessary for the cells to construct a sufficient microfibrillar network binding and detection of pulse-labeled fibrillin molecules in insoluble form during a 20-hour chase period. This fraction is decreased to a varying extent in fibroblast cultures of four biosynthetically distinct groups of Marfan's syndrome patients, but only Groups II and IV clearly showed reduction in immunostainable microfibrils. In long-term cultures, immunoelectron microscopy of the extracellular matrix with fibrillin antibodies also detected differences among these groups and in comparison to normal controls with respect to the arrangement of fibrillin-containing microfibrils, thickness of microfibrillar bundles, and the presence of amorphous material. The data support the idea of different pathogenetic mechanisms for each biosynthetically defined group of Marfan's syndrome, which depends on the nature of fibrillin-1 mutations.
Thymosin β4 and Fx, an actin-sequestering peptide, are indistinguishable (1991)

At least 50% of the actin in resting human platelets is unpolymerized, and the bulk of this unpolymerized actin is complexed with a recently identified acidic, heat-stable 5-kDa peptide, named "Fx." Purified Fx binds stoichiometrically to muscle G-actin, forming a complex identifiable by nondenaturing polyacrylamide gel electrophoresis. Formation of the complex inhibits salt-induced polymerization of G-actin. Here we report that Fx is indistinguishable from thymosin beta 4, an acidic, heat-stable 5-kDa peptide first isolated from calf thymus and thought to be a thymic hormone. The complete amino acid sequence of Fx was determined and was found to be identical with that of thymosin beta 4. Authentic thymosin beta 4 is functionally equivalent to Fx, forming a 1:1 complex with actin monomers and inhibiting polymerization. The widespread distribution and high intracellular concentration of thymosin beta 4 (Fx) strongly suggest that it plays a significant role in regulating actin polymerization in many cell types.
Blow Molded Reinforced High Density Polyethylene for Structural Applications (1983)

<div class="htmlview paragraph">The first reinforced high density polyethylene blow molding compound with engineering properties has been developed by Phillips Chemical Company in a two-year joint program with Fisher Body Division of General Motors and Ford Motor Company. Chemically coupled mica, compounded with a Marlex <sup>®</sup> high molecular weight high density polyethylene copolymer, results in a material having dramatically improved stiffness at both room temperature and elevated (180°F) temperatures.</div> <div class="htmlview paragraph">The high rigidity of this material has allowed reduced piece weight and significant cost savings in three automotive seat back panel and load floor applications. A full width seat back weighing about half of a metal frame is now being used in the Chevrolet Camaro, Chevrolet Z28 and Pontiac Firebird. A split seat back version is standard in the Pontiac Trans Am. Ford has realized impressive cost savings using a large mica reinforced high density polyethylene load floor in their Escort EXP and Lynx LN7 cars. The success of these blow molded applications has spawned promising development work in thermoforming and sheet compression molding processes.</div>
Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease (2019)

Monoamine oxidase-B (MAO-B) has recently emerged as a potential therapeutic target for Alzheimer's disease (AD) because of its association with aberrant γ-aminobutyric acid (GABA) production in reactive astrocytes. Although short-term treatment with irreversible MAO-B inhibitors, such as selegiline, improves cognitive deficits in AD patients, long-term treatments have shown disappointing results. We show that prolonged treatment with selegiline fails to reduce aberrant astrocytic GABA levels and rescue memory impairment in APP/PS1 mice, an animal model of AD, because of increased activity in compensatory genes for a GABA-synthesizing enzyme, diamine oxidase (DAO). We have developed a potent, highly selective, and reversible MAO-B inhibitor, KDS2010 (IC<sub>50</sub> = 7.6 nM; 12,500-fold selectivity over MAO-A), which overcomes the disadvantages of the irreversible MAO-B inhibitor. Long-term treatment with KDS2010 does not induce compensatory mechanisms, thereby significantly attenuating increased astrocytic GABA levels and astrogliosis, enhancing synaptic transmission, and rescuing learning and memory impairments in APP/PS1 mice.
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin (2012)

Aminoglycosides are potent antibacterials, but therapy is compromised by substantial toxicity causing, in particular, irreversible hearing loss. Aminoglycoside ototoxicity occurs both in a sporadic dose-dependent and in a genetically predisposed fashion. We recently have developed a mechanistic concept that postulates a key role for the mitochondrial ribosome (mitoribosome) in aminoglycoside ototoxicity. We now report on the surprising finding that apramycin, a structurally unique aminoglycoside licensed for veterinary use, shows little activity toward eukaryotic ribosomes, including hybrid ribosomes which were genetically engineered to carry the mitoribosomal aminoglycoside-susceptibility A1555G allele. In ex vivo cultures of cochlear explants and in the in vivo guinea pig model of chronic ototoxicity, apramycin causes only little hair cell damage and hearing loss but it is a potent antibacterial with good activity against a range of clinical pathogens, including multidrug-resistant Mycobacterium tuberculosis. These data provide proof of concept that antibacterial activity can be dissected from aminoglycoside ototoxicity. Together with 3D structures of apramycin-ribosome complexes at 3.5-Å resolution, our results provide a conceptual framework for further development of less toxic aminoglycosides by hypothesis-driven chemical synthesis.
Thin-Film Laser-to-Fiber Coupler (1974)

A laser-to-fiber coupler is described in which a thin-film waveguide is used to focus an incoming laser beam into the core of a cladded fiber. The latter is accurately aligned with respect to the waveguide by means of a V channel produced by a differential etching technique. Although over-all coupling efficiencies have not exceeded 10% so far, it is estimated that efficiencies of 50% or more should be feasible. This type of coupler may be useful in applications where compactness, ruggedness, and low cost are important.
The origin of Taraxacum agamospecies (1973)

Journal Article The origin of Taraxacum agamospecies Get access A. J. RICHARDS A. J. RICHARDS 1Department of Botany, University of Newcastle upon Tyne Newcastle upon Tyne NE1 7RU, England Search for other works by this author on: Oxford Academic Google Scholar Botanical Journal of the Linnean Society, Volume 66, Issue 3, April 1973, Pages 189–211, https://doi.org/10.1111/j.1095-8339.1973.tb02169.x Published: 28 June 2008 Article history Accepted: 01 June 1972 Published: 28 June 2008
Cardiac mapping at Duke Medical Center. (1989)

CLINICAL PERSPECTIVE: Ventricular fibrillation is a major, but little understood, cause of death. Although defibrillation with electric shock has been in use for several decades, and although many advances have been made in the design of defibrillators (including the development of implantable devices for high-risk patients), this procedure has generally been an empiric one. The mechanisms of the procedures are being intensely studied at Duke University and other institutions in the hope of developing more energy efficient and clinically effective defibrillation equipment.
Development of 111 texture in Al films grown on SiO2/Si(001) by ultrahigh-vacuum primary-ion deposition (1996)

A high degree of 111 preferred orientation with minimal mosaic spread has been shown by many researchers to be essential for electromigration resistance in Al-based interconnects. We have found that 111 texture can be greatly enhanced through the use of low-energy self-ion irradiation during deposition. In these experiments, 300-nm-thick Al layers were grown on SiO2 at 65 °C from highly ionized beams provided by an ultrahigh-vacuum primary-ion deposition (PID) source. Al+ ion energies EAl+ and ion/neutral ratios JAl+/JAl were independently varied from 10 to 120 eV and from 0% to 68%, respectively. All PID Al films exhibited very strong 111 preferred orientations, which increased with increasing EAl+ and/or JAl+/JAl, and azimuthally symmetric x-ray diffraction pole figures with no measurable tilt. The full width at half-maximum intensity Δω of 111 ω-rocking curves decreased continuously from 9.6° with EAl+=10 eV and JAl+/JAl=68% to 2.2° with JAl+/JAl=120 eV compared to 10.6° for films deposited by thermal evaporation. This was accompanied by a continuous decrease in the average grain size from 370 nm for thermal deposition to 90 nm with EAl+=120 eV. The PID Al films exhibited a columnar microstructure with weak competitive column growth. Changing the beam energy after the formation of a continuous layer had only a minor effect on film texture, indicating that the degree of ion-irradiation-induced preferred orientation is controlled during nucleation and/or coalescence while local pseudomorphic forces dominate thereafter. ω-rocking curves from a bilayer film consisting of a 20-nm-thick Al buffer layer grown by PID followed by a 280-nm-thick thermally evaporated Al overlayer were essentially identical to those obtained from 300-nm-thick single-layer PID Al films.
Dictionary of Plant Breeding (2009)

Arguably one of the oldest scientific traditions, plant breeding began in Neolithic times, with methods as simple as saving the seeds of desirable plants and sowing them later. It was not until the re-encounter with Mendel's discoveries thousands of years later that the genetic basis of breeding was understood. Developments since then have provided
ChemInform Abstract: “Carbathia” Analogues of Platelet Activating Factor (PAF). (1987)

Abstract The sulfur analogues (Ic) and (Id) of "2‐carba" PAF (Ia) and (Ib) are prepared by an eight‐step synthesis.
Multi-probe LSH: efficient indexing for high-dimensional similarity search (2007)

Similarity indices for high-dimensional data are very desirable for building content-based search systems for feature-rich data such as audio, images, videos, and other sensor data. Recently, locality sensitive hashing (LSH) and its variations have been proposed as indexing techniques for approximate similarity search. A significant drawback of these approaches is the requirement for a large number of hash tables in order to achieve good search quality. This paper proposes a new indexing scheme called multi-probe LSH that overcomes this drawback. Multi-probe LSH is built on the well-known LSH technique, but it intelligently probes multiple buckets that are likely to contain query results in a hash table. Our method is inspired by and improves upon recent theoretical work on entropy-based LSH designed to reduce the space requirement of the basic LSH method. We have implemented the multi-probe LSH method and evaluated the implementation with two different high-dimensional datasets. Our evaluation shows that the multi-probe LSH method substantially improves upon previously proposed methods in both space and time efficiency. To achieve the same search quality, multi-probe LSH has a similar time-efficiency as the basic LSH method while reducing the number of hash tables by an order of magnitude. In comparison with the entropy-based LSH method, to achieve the same search quality, multi-probe LSH uses less query time and 5 to 8 times fewer number of hash tables.
Reconstruction of Underwater Image by Bispectrum (2007)

Reconstruction of an underwater object from a sequence of images distorted by moving water waves is a challenging task. A new approach is presented in this paper. We make use of the bispectrum technique to analyze the raw image sequences and recover the phase information of the true object. We test our approach on both simulated and real-world data, separately. Results show that our algorithm is very promising. Such technique has wide applications to areas such as ocean study and submarine observation.
A bipolar ECL static RAM using polysilicon-diode loaded memory cell (1989)

A 1 K*1 bipolar ECL (emitter-coupled logic) static RAM using polysilicon-diode loaded memory cell is realized in a single-poly bipolar process technology. The use of the polysilicon diode as the load element for the memory cell is made possible by the fact that its I-V characteristics exhibit an ideality factor of two. The hold voltage for the memory cell is larger than 240 mV over a wide range of cell currents with the lower bound residing in the submicroampere range. Results show extremely stable operation against row-select sensitivity. A 1.5-ns row address access time has been obtained from the test circuit.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Biofungicides as alternative to synthetic fungicide control of grey mould (<i>Botrytis cinerea</i>) – prospects and challenges (2018)

Botrytis cinerea is one of the most destructive pathogens of ve⁠getables and fruits both in the field and storage. There have been several research activities focused on developing biocontrol strategies for the pathogen due to its resistance to the commonly used synthetic fungicides. Additionally, concerns have been raised over residual effect of current synthetic fungicides used for its control. Most of these research activities have focused on Trichoderma spp., Ulocladium spp., Bacillus subtilis, plant extracts and their essential oils with some commercial products available on the market for the control of B. cinerea disease. This review summarises some of the current published information on the use of biocontrol agents and plant-based compounds for B. cinerea control. Some limitations and future prospects were also mentioned.
PROTEINS BY DESIGN (1998)

RETURN TO ISSUEPREVNewsNEXTPROTEINS BY DESIGNScientists create proteins that curl themselves up with a unique new twistSTU BORMANCite this: Chem. Eng. News 1998, 76, 47, 9Publication Date (Print):November 23, 1998Publication History Published online12 November 2010Published inissue 23 November 1998https://doi.org/10.1021/cen-v076n047.p009Copyright © 1998 AMERICAN CHEMICAL SOCIETYArticle Views4Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (152 KB) SUBJECTS:Biochemistry,Molecular design,Order,Protein structure,Students Get e-Alerts
Structure of the troponin complex. Implications of photocross-linking of troponin I to troponin C thiol mutants. (1994)

Ca2+ regulation of vertebrate-striated muscle contraction is initiated by conformational changes in the Ca(2+)-binding protein troponin C (TnC) and subsequent changes in the interaction of TnC with the inhibitory protein TnI. We have constructed mutants of rabbit skeletal muscle TnC in which natural Cys-98 was replaced by Leu, and a single Cys residue was introduced at position 12 (TnC12) or 89 (TnC89). Cys residues of mutant TnCs were derivatized with 4-maleimidobenzophenone and photocross-linked to TnI in binary TnC.TnI complexes. After digestion with CNBr or proteases, cross-linked peptides were purified and sequenced. TnC12 cross-linked at or near TnI Met-134 in a region known to be sensitive not only to occupancy of the regulatory Ca(2+)-binding sites of TnC but also to the contractile state of the thin filament. TnC89 cross-linked to TnI(108-113) in the inhibitory region. Taken together with earlier findings, these results indicate that in the TnC.TnI complex, both domains of TnC, as well as the linker region between them, make contact with the inhibitory region of TnI. Our data also indicate that the N- and C-terminal domains of TnC interact with opposite ends of the TnI inhibitory region.