gebhart/patrepeval huggingface dataset:
The LEGO MINDSTORMS NXT 2.0 Discovery Book: A Beginner's Guide to Building and Programming Robots (2010)

Why this book? The LEGO MINDSTORMS EV3 robotics set offers unlimited possibilities to build and program robots, but exploring beyond the instructions included in the set can be a bit overwhelming when youre just getting started. The LEGO MINDSTORMS EV3 Discovery Book is designed to help you discover the power of LEGO MINDSTORMS as you learn to invent, build, and program your very own robots. How does this book work? This book assumes no previous experience with either building or programming LEGO MINDSTORMS, and each chapter presents a mix of robot building, programming theory, and challenges to help you really understand the concepts. Youll learn basic programming techniques at the same time that you make your first robot move, and youll learn about more advanced programming as you build increasingly sophisticated robots. The challenges, called Discoveries, encourage you to expand the example programs, modify the mechanical design, or even invent completely new robots! A Guided Tour The LEGO MINDSTORMS EV3 Discovery Book is divided into six parts: Part I: Getting Started takes you through the contents of the EV3 robotics set and shows you how to build your first robot. Youll meet the EV3 software and basic programming blocks that youll use to make your robot move. You'll also learn essential programming techniques, such as making your robot repeat actions and do more than one thing at the same time. Part II: Programming Robots with Sensors teaches you all about sensors, which are essential components of MINDSTORMS robots. Youll add the Touch Sensor to the robot you built earlier, and youll explore the functions of the Color Sensor, the Infrared Sensor and the infrared beacon, and the Rotation Sensors inside each of the motors. Part III: Robot Building Techniques covers the LEGO Technic building elements that come with your EV3 set. Youll learn to use beams, axles, connector blocks, and gears effectively in your own robots. Part IV: Vehicle and Animal Robots puts your skills with motors and sensors to the test as you build two new robotsthe Formula EV3 Race Car and ANTY, a robotic ant. Part V: Creating Advanced Programs is devoted to advanced programming concepts. Youll learn about data wires, how to process sensor values and do math on the EV3, and how to make the robot remember things with variables. Finally, you'll combine all of these programming techniques to create a robot that lets you play games on the EV3 screen. Part VI: Machine and Humanoid Robots combines everything youve learned to guide you through creating two complex robots. Youll build and program the SNATCH3R, an autonomous robotic arm that can find, grab, lift, and move the infrared beacon autonomously, and the LAVA R3X, the walking, talking humanoid shown on the front cover.
A Practical Web-Based NSS Framework for E-Business Negotiation (2005)

As a requisite to the complete e-business revolution, Negotiation Support System (NSS) today hasn't been widely adopted in real e-Business negotiation practices, despite years of research on it. On the basis of our former work on NSS, this paper focuses on the implementation of theories, models and technologies into practice. The web-based negotiation support framework presented in this paper is practical, in that: a) different negotiation protocols can be adopted; b) business negotiations can be supported dynamically according to participants' settings; c) the framework offers easy-to-maintain business logic and decision models; d) the system may be hopefully integrated into corporate information systems. A common negotiation protocol is designed; and a linear negotiation mediation models is given. An implementation that enables the outstanding features of this framework is discussed as well.
JNJ-61186372 (JNJ-372), an EGFR-cMet bispecific antibody, in EGFR-driven advanced non-small cell lung cancer (NSCLC). (2019)

9009 Background: JNJ-372 binds EGFR and cMet to block ligand binding, promote receptor degradation, and trigger antibody-dependent cellular cytotoxicity in models of EGFR-mutated (EGFRm) NSCLC. Here we describe the ongoing phase 1 safety, pharmacokinetics (PK), and activity of JNJ-372 in patients (pts) with NSCLC, including 3 rd generation tyrosine kinase inhibitor (3GTKI)-relapsed EGFRm NSCLC and EGFR Exon20ins disease. Methods: Pts received JNJ-372 (140–1400 mg) IV weekly for the first 28-day cycle and biweekly thereafter. 1050–1400 mg doses are being explored in dose expansion. Blood samples were collected for PK analyses. Efficacy by investigator per RECIST v1.1 in pts with EGFRm NSCLC treated at ≥700 mg is presented. Tumors were characterized by next-generation sequencing of circulating tumor (ct)DNA and/or tumor tissue. Results: As of 17 Jan 2019, 116 enrolled pts with NSCLC were treated. Median age was 63 years, 38% were male, 77% were Asian, and 97% had EGFR mutations. Mean duration of treatment was 3.8 months, longest exposure was 20 cycles. The PK data set included pts from Korea (77%) and the US (23%). At the 1050 mg dose, 72% of pts achieved average concentrations above the EC 90 based on preclinical models. Adverse events (AEs; ≥20%) were rash (59%), infusion related reaction (58%), paronychia (28%), and constipation (22%). Additional EGFR/cMet-related AEs include stomatitis (17%), pruritis (15%), peripheral edema (11%), and diarrhea (7%). Grade ≥3 AEs were reported in 34% (8% treatment-related) with dyspnea (6%) and pneumonia (3%) most frequently observed. Among response-evaluable pts, 25/88 (28%) achieved best timepoint response of partial response (PR). 10/47 pts with prior 3GTKI therapy had best timepoint response of PR (6 confirmed), including 4 with C797S, 1 with cMet amplification, and 5 without identifiable EGFR/cMet-dependent resistance. 6/20 pts with Exon20ins had best timepoint response of PR (3 confirmed). Conclusions: JNJ-372 has a manageable safety profile consistent with EGFR and cMet inhibition. Preliminary responses were achieved in 3GTKI-relapsed disease, including C797S and cMet amplification, and Exon20ins disease; enrollment in dose expansion is ongoing. Clinical trial information: NCT02609776.
Real-time performance of textile electrodes in electromyogram pattern-recognition based prosthesis control (2012)

Textile electrode is flexible, folding, washable and biocompatible with skin. With these advantages, the textile electrodes should be an ideal alternative for electromyogram (EMG) recordings in clinical applications. In this study, a textile electrode system was used for EMG signal recordings and its usability and performance in classifying different arm and hand movements were evaluated through real-time pattern recognition control of virtual myoelectric arm. Our results showed that the offline average classification accuracy over seven able-bodied subjects for all ten movements was 91.81%, compared to 96.54% for six basic movements. The real-time performance in operating a virtual arm was quantified with three measures: selection time, completion time, and completion time. Averagely, the seven subjects achieved a motion selection time of approximately 0.36 s, and a completion time of less than 2 s, and a completion rate of around 82%. These pilot results suggest that the textile electrodes could work well in real-time control of multifunctional myoelectric prosthesis.
Epigenetics in development (2007)

It has become increasingly evident in recent years that development is under epigenetic control. Epigenetics is the study of heritable changes in gene function that occur independently of alterations to primary DNA sequence. The best-studied epigenetic modifications are DNA methylation, and changes in chromatin structure by histone modifications, and histone exchange. An exciting, new chapter in the field is the finding that long-distance chromosomal interactions also modify gene expression. Epigenetic modifications are key regulators of important developmental events, including X-inactivation, genomic imprinting, patterning by Hox genes and neuronal development. This primer covers these aspects of epigenetics in brief, and features an interview with two epigenetic scientists.
Disinfection of bore well water with chlorine dioxide/sodium hypochlorite and hydrodynamic cavitation (2014)

The effect of hydrodynamic cavitation (HC) on potable water disinfection of chemicals was investigated. The bore well water was introduced into HC set-up to examine the effect of HC alone and combination of HC and chemicals such as chlorine dioxide and sodium hypochlorite. The effect of inlet pressure and geometrical parameters on disinfection was studied using HC alone and the results showed that increasing inlet pressure and using more and bigger holes of orifice plates can result in a higher disinfection rates. When HC was combined with chemicals, HC can reduce the doses of the chemicals and shorten the time of disinfection. It was also found that the decrease in bacteria concentration followed a first-order kinetic model. As for the experiment of combination of HC and sodium hypochlorite for disinfection, HC not only improves the disinfection rate but also degrades natural organic matter and chloroform. Compared with only sodium hypochlorite disinfection, combined processes get higher disinfection rate and lower production of chloroform, particularly the pretreatment with HC enhances the disinfection rate by 32% and there is a simultaneous reduction in production of chloroform by 39%.
Membrane sphingolipids as essential molecular signals for <i>Bacteroides</i> survival in the intestine (2010)

As predominant intestinal symbiotic bacteria, Bacteroides are essential in maintaining the health of the normal mammalian host; in return, the host provides a niche with plentiful nutrients for the symbionts. However, the intestinal environment is replete with chemical, physical, and biological challenges that require mechanisms for prompt and adept sensing of and responses to stress if the bacteria are to survive. Herein we propose that to persist in the intestine Bacteroides take advantage of their unusual bacterial sphingolipids to mediate signaling pathways previously known to be available only to higher organisms. Sphingolipids convey diverse signal transduction and stress response pathways and have profound physiological impacts demonstrated in a variety of eukaryotic cell types. We propose a mechanism by which the formation of specific sphingolipid membrane microdomains initiates signaling cascades that facilitate survival strategies within the bacteria. Our preliminary data suggest that sphingolipid signaling plays an important role in Bacteroides physiology, enabling these bacteria to persist in the intestine and to perform other functions related to symbiosis.
Re: Effectiveness of Silicone Sheets in the Prevention of Hypertrophic Breast Scars (1997)

Department of Plastic, Reconstructive and Hand Surgery University Hospital Utrecht PO Box 85500, 3508 GA Utrecht The Netherlands
An Alkaline D-Stereospecific Endopeptidase with β-Lactamase Activity from Bacillus cereus (1996)

We purified a novel extracellular D-stereospecific endopeptidase, alkaline D-peptidase (D-stereospecific peptide hydrolase, EC 3.4.11.-), to homogeneity from the culture broth of the soil bacterium Bacillus cereus strain DF4-B. The Mr of the enzyme was 37,952, and it was composed of a single polypeptide chain. The optimal pH for activity was approximately 10.3. The enzyme was strictly D-stereospecific toward oligopeptides composed of Dphenylalanine such as (D-Phe)3 and (D-Phe)4. The enzyme also acted to a lesser extent on (D-Phe)6, Boc-(D-Phe)4 (where Boc is tert-butoxycarbonyl), Boc-(D-Phe)4 methyl ester, Boc-(D-Phe)3 methyl ester, Boc-(D-Phe)2, (D-Phe)2, and others, but not upon their corresponding peptides composed of L-Phe, (D-Ala)n (n = 2-5), (D-Val)3, and (D-Leu)2. The mode of action of the enzyme was clarified with synthetic substrates ((D-Phe)2-D-Tyr and D-Tyr-(D-Phe)2) and eight stereoisomers of (Phe)3. The enzyme had beta-lactamase activity toward ampicillin and penicillin G, although carboxypeptidase DD and D-aminopeptidase activities were undetectable. The gene coding for alkaline D-peptidase (adp) was cloned into plasmid pUC118, and a 1164-base pair open reading frame consisting of 388 codons was identified as the adp gene. The predicted polypeptide was similar to carboxypeptidase DD from Streptomyces R61, penicillin-binding proteins from Streptomyces lactamdurans and Bacillus subtilis, and class C beta-lactamases. Thus, the enzyme was categorized as a new "penicillin-recognizing enzyme."
Reoperation for myocardial revascularization (1978)

Abstract At The Cleveland Clinic Foundation, reoperations for myocardial revascularization make up 2.7% of all cardiac operations. Major indications for reoperation include: (a) graft failure, (b) progressive atherosclerosis in grafted or ungrafted vessels, (c) previous incomplete revascularization, and (d) combinations of the other 3. Almost one‐half of the candidates satisfy more than 1 of the first 3 indications. Although few in number, late graft closure due to atherosclerosis is seen with increasing frequency. Systemic hypothermia coupled with intermittent cold cardioplegia shortens operating time, enhances myocardial protection, and markedly reduces the occurrence of low cardiac output postoperatively. Recent methods of blood conservation and their potential effect on morbidity are discussed . In the first 219 patients operated on through mid‐1975, the operative mortality rate was 3.7%, and in subsequent years it was 2%. Although complete relief of angina is achieved less frequently after reoperation, in a follow‐up period of 2.5 years, 87% of the 202 surviving patients improved at least one functional class. Relief of angina is virtually the same for each indication category. Those with progressive atherosclerosis had essentially the same clinical result as those operated on for graft failure. A successful result depends on selection of patients with adequate vessel caliber and runoff. Internal mammary artery (IMA) grafting is the procedure of choice for a failed anterior descending vein graft. Although complete revascularization is ideal, many of those who still have perfusion deficits because of diffuse disease can be improved clinically .
An Efficient Synchronous Collaborative Editing System Employing Dynamic Locking of Varying Granularity in Generalized Document Trees (2006)

The primary goals in a synchronous collaborative editing system (CES) involve ensuring a high level of concurrent access while maintaining the properties of the CCI model. We revisit the idea of applying lock-based concurrency control algorithms to manage access to a shared document; this research overcomes the traditional problem of reduced concurrent access inherent in pessimistic concurrency control by dynamically managing the size of the portion of document locked based upon user demand, scaling up and down the lock granularity to accommodate user write requests. We present algorithms to efficiently maximize concurrent access while utilizing caching techniques to reduce communication costs. We also discuss how OT and other optimistic concurrency control techniques may be incorporated within our approach ? leveraging best practices of both techniques. We conclude with an analysis of the communication and computational costs of our approach and compare these costs to costs incurred using OT-based concurrency control.
Visual Correlation Analysis of Numerical and Categorical Data on the Correlation Map (2014)

Correlation analysis can reveal the complex relationships that often exist among the variables in multivariate data. However, as the number of variables grows, it can be difficult to gain a good understanding of the correlation landscape and important intricate relationships might be missed. We previously introduced a technique that arranged the variables into a 2D layout, encoding their pairwise correlations. We then used this layout as a network for the interactive ordering of axes in parallel coordinate displays. Our current work expresses the layout as a correlation map and employs it for visual correlation analysis. In contrast to matrix displays where correlations are indicated at intersections of rows and columns, our map conveys correlations by spatial proximity which is more direct and more focused on the variables in play. We make the following new contributions, some unique to our map: (1) we devise mechanisms that handle both categorical and numerical variables within a unified framework, (2) we achieve scalability for large numbers of variables via a multi-scale semantic zooming approach, (3) we provide interactive techniques for exploring the impact of value bracketing on correlations, and (4) we visualize data relations within the sub-spaces spanned by correlated variables by projecting the data into a corresponding tessellation of the map.
An investigation of zirconium(iv)–glycine(CP-2) hybrid complex in bovine serum albumin protein matrix under varying conditions (2011)

The morphological and structural transformation process of the water soluble zirconium–glycine hybrid cluster [Zr6(O)4(OH)4(H2O)8(Gly)8]12+ (CP-2) in a bovine serum albumin (BSA) protein matrix was comprehensively investigated. Based on the zeta-potential analysis, positive CP-2 clusters tend to adsorb onto the surface of the backbone of BSA, forming BSA–CP-2 hybrids through direct mixing. After aging the solution at 37 °C for several weeks, white floccules appeared in solution indicating the phase transformation of BSA–CP-2 bio–inorganic hybrid. A series of characterizations (zeta-potential measurements, dynamic light scattering measurements, transmission and scanning electron microscopy, X-ray diffraction, and so on) were carried out to analyze the interaction between CP-2 and BSA under varying pH value and salt concentrations in order to demonstrate the transformation of the CP-2 to amorphous ziconium hydroxide. The coagulant action of CP-2 with BSA indicates that the zirconium(IV)–glycine complex may be efficacious as an antiperspirant and in water treatment.
Synthese von durchhydrierten Dipiperidazino‐tetrazin, ‐tetrazepin‐ und ‐tetrazozinderivaten (1966)

Abstract Aus Piperidazin (I) konnte mit Formaldehyd Dipiperidazino‐(1′,2′‐a; 1″,2″‐d)‐perhydro‐1,2,4,5‐tetrazin (III) synthetisiert werden; mit Benzaldehyd entstand Dipiperidazino‐(1,2′‐a; 1″,2″‐d)3,6‐diphenylhexahydro‐1,2,4,5‐tetrazin (IV). Aus dem als Nebenprodukt bei der Synthese von I anfallenden 1‐Carbäthoxy‐piperidazin (II) konnte unter analogen Bedingungen Bis(1,1′‐Carbäthoxypiperidazyl‐2,2′‐)methan (V) erhalten werden. Zum Aufbau des 1,2‐Bis(1‐piperidazyl)‐äthan (VIII) wurde I mit Oxalester zu Bis(1‐piperidazyl)‐oxamid (VII) umgesetzt, das sich mit LiAlH 4 zu VIII reduzieren ließ. VIII konnte auch direkt aus I und Dibromäthan erhalten werden. Mit Formaldehyd konnte der mittlere Siebenring geschlossen werden zu Dipiperidazino‐(1′,2′‐a; 1″,2″‐d)‐perhydro‐1,2,4,5‐tetrazepin (IX). Zur Synthese des 3,4‐Dioxodipiperidazino‐(1′,2″‐a; 1″,2″‐e)‐perhydro‐1,2,5,6‐tetrazozins (X) wurde VIII mit Oxalylchlorid umgesetzt. Die Reduktion von X mit LiAlH 4 ergab Dipiperidazino‐(1′,2′‐a; 1″,2″‐e)‐perhydro‐1,2,5,6‐tetrazozin (XI).
Emergence of nanotechnology in the oil and gas industry: Emphasis on the application of silica nanoparticles (2017)

The application of nanotechnology in the oil and gas industry is on the rise as evidenced by the number of researches undertaken in the past few years. The quest to develop more game-changing technologies that can address the challenges currently facing the industry has spurred this growth. Several nanoparticles, of different sizes and at different concentrations, have been used in many investigations. In this work, the scope of the study covered the application of nanotechnology in drilling and hydraulic fracturing fluids, oilwell cementing, enhanced oil recovery (which includes transport study, and foam and emulsion stability), corrosion inhibition, logging operations, formation fines control during production, heavy oil viscosity reduction, hydrocarbon detection, methane release from gas hydrates, and drag reduction in porous media. The observed challenges associated with the use of nanoparticles are their stability in a liquid medium and transportability in reservoir rocks. The addition of viscosifier was implemented by researchers to ensure stability, and also, surface-treated nanoparticles have been used to facilitate stability and transportability. For the purpose of achieving better performance or new application, studies on synergistic effects are suggested for investigation in future nanotechnology research. The resulting technology from the synergistic studies may reinforce the current and future nanotechnology applications in the oil and gas industry, especially for high pressure and high temperature (HPHT) applications. To date, majority of the oil and gas industry nanotechnology publications are reports of laboratory experimental work; therefore, more field trials are recommended for further advancement of nanotechnology in this industry. Usually, nanoparticles are expensive; so, it will be cost beneficial to use the lowest nanoparticles concentration possible while still achieving an acceptable level of a desired performance. Hence, optimization studies are also recommended for examination in future nanotechnology research.
Electron Cyclotron Resonance Plasma Etching of AlGaN in Cl2/Ar and BCl3/Ar Plasmas (1997)

A comparison of etch rates for alloys was performed in /Ar and /Ar electron cyclotron resonance plasmas. The etch rates were generally found to decrease with increasing AlN concentration, due to the increasing average bond strengths at higher Al compositions. The fastest rates were found in the /Ar chemistry, with rates of ∼3500 Å/min for GaN, 1700 Å/min for AlN, 2500 Å/min for , and 3300 Å/min for . The etched surfaces were also smoother with the /Ar plasma chemistry than the /Ar plasma chemistry. The etch selectivities for GaN over , and AlN were quite low, ⩽5 for all conditions, and this is due to the ion‐driven nature of the removal mechanism.
Twisting of Conjugated Oligomers and Polymers: Case Study of Oligo‐ and Polythiophene (2007)

Interring twisting (change in the dihedral angle between conjugated rings) of polythiophene was studied theoretically using periodic boundary conditions (PBC) at the B3LYP/6-31G(d) level. We find that the band gap of polymers is strongly dependent on the interring twist angle; yet twisting requires very little energy. A twist of 30 degrees increases the band gap by 0.75 eV in polythiophene, while requiring only 0.41 kcal mol(-1) per monomer unit. Such a small energetic value is of the order of crystal packing or van der Waals forces. These results are compared with calculations performed on model oligomers. Sexithiophene, its radical cations, and its dication are optimized at 0-180 degrees end-to-end twist angles (which correspond to 0-36 degrees interring dihedral angles) using the B3LYP/6-31G(d) method. The theoretical results suggest that the HOMO-LUMO gap, ionization potential, and charge distribution of oligomers are strongly dependent on twisting, whereas, similar to the case of polythiophene, twisting of neutral oligothiophenes costs very little energy. In the case of the radical cation, the lowest energy transition is shifted to a longer wavelength region on twisting, while the second-lowest energy transition is shifted to a shorter wavelength region. This implies that twisted, doped conducting polymers (modeled here by an oligomer radical cation), in contrast to planar, doped polymers, should be transparent within a certain optical window (in the far-visible region, at approximately 1.5 eV). This observation is explained on the basis of changes in the shape and overlap of the frontier molecular orbitals.