gebhart/patrepeval huggingface dataset:
Enhancement-mode AlGaN/GaN HEMTs Fabricated by Standard Fluorine Ion Implantation (2010)

Abstract: This paper presents a fabrication technology of enhancement-mode AlGaN/GaN HEMTs using standard fluorine ion implantation. An 80 nm silicon nitride layer was deposited on the AlGaN as an energy-absorbing layer that slows down the high energy (~25 keV) fluorine ions so that majority of the fluorine ions are incorporated in the AlGaN barrier. The threshold voltage was successfully shifted from-1.9 V to +0.6 V, converting depletion mode HEMTs to enhancement-mode ones. The fluorine ion distribution profile was measured by Secondary Ion Mass Spectrometry (SIMS) and is consistent with results from SRIM (The Stopping and Range of Ions in Matter) simulation. Owing to superior physical properties such as high electron saturation velocity and high electric breakdown field, GaN-based high electron mobility transistors (HEMTs)
Comparison of the aging behavior of diffused and epitaxial GaAlAs heterojunction electroluminescent diodes (1981)

Two Types of GaAlAs heterojunction electroluminescent diodes are compared. In the planar-type diffused diode the p-n homojunction is obtained by zinc diffusion in areas limited by a silicon nitride mask; the p-p heterojunction confines electrons in the bulk and avoids surface recombinations. The epitaxial diode is a conventional double heterojunction; the active area is limited by proton bombardment. The aging behaviors of these two types appear quite different. Diffused diodes degrade relatively fast; under continuous operation at 550 A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (100 mA) the device lifetime (emitted light power falling down to 50 percent of the initial value) is 10 000 to 50 000 h. Epitaxial diodes degrade much more slowly; their device lifetime is estimated at several 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> h. The degradation is followed during aging, by using electrical and optical measurements, together with SEM and TEM analyses. It is confirmed that fast degradation occurs with simultaneous growth of dark line defects (DLD) and that these DLD's result from dislocation dipoles of interstitial nature, emitted either from scratches or, more frequently, from previously existing dislocations. It is shown that epitaxial diodes are practically free of dislocations; on the contrary, in the case of planar-type p-n junctions, a large number of dislocation loops are developed at the junction periphery, resulting from the mechanical stress at the edge of the junction during processing. This is the main source of DLD's and fast degradation of planar-type diffused diodes.
Performance Analysis of Optimum Interleaver based on Prime Numbers for Multiuser Iterative IDMA Systems (2010)

In recently proposed multiple access techniques like IDMA and OFDM-IDMA, the user separation is done by user specific interleavers in contrast to the conventional CDMA scheme, where user separation is assured with user-specific signature sequences. The user specific interleavers must demonstrate minimum probability of collision amongst each other in addition to other merits, including minimal consumption of bandwidth, least hardware for their generation, and least memory requirement. In this paper, the authors propose an interleaver based on prime numbers for the generation of user specific interleavers to remove the problem of high consumption of bandwidth. The simulation results demonstrate the optimal performance of prime interleaver (PI), which is based on prime numbers, apart from other merits in comparison to random and other interleavers.
An Arduino-based EIS with a logarithmic amplifier for corrosion monitoring (2014)

Electrochemical Impedance Spectroscopy (EIS) is an interesting non-invasive technique to study the corrosion layer of metallic artifacts as well as to test the integrity of protective coatings, however commercial EIS systems are rather expensive devices. This paper describes an extremely low cost realization of an EIS system that is based on a simple commercial Arduino Board whose cost is below 50$. The instrument is able to perform impedance measurements in the range 1 kΩ to 1 GΩ, thanks to a specifically designed front end based on a logarithmic amplifier, and in the frequency range of 0.01 Hz to 100 kHz. The instrument can work as a stand-alone device or connected to a PC. The required current is of about 100 mA, thus, the USB port of a common laptop can power the instrument for several hours without external supply. It is also possible to employ several instruments at the same time for a massive parallel measurement campaign with a negligible cost. The instrument accuracy is of about 2% for impedances in the range of 1 kΩ to 100 MΩ, with uncertainty on the phase of about 2°.
CircleView (2004)

This paper introduces a new approach for visualizing multidimensional time-referenced data sets, called Circle View. The Circle View technique is a combination of hierarchical visualization techniques, such as treemaps [6], and circular layout techniques such as Pie Charts and Circle Segments [2]. The main goal is to compare continuous data changing their characteristics over time in order to identify patterns, exceptions and similarities in the data.To achieve this goal Circle View is a intuitive and easy to understand visualization interface to enable the user very fast to acquire the information needed. This is an important feature for fast changing visualization caused by time related data streams. Circle View supports the visualization of the changing characteristics over time, to allow the user the observation of changes in the data. Additionally it provides user interaction and drill down mechanism depending on user demands for a effective exploratory data analysis. There is also the capability of exploring correlations and exceptions in the data by using similarity and ordering algorithms.
Reduction in Gs?? Induces Osteogenic Differentiation in Human Mesenchymal Stem Cells (2005)

We hypothesized that a decrease in Gsalpha expression occurs with osteogenic differentiation and that when Gsalpha expression was decreased by antisense oligonucleotides or direct inhibition of protein kinase A there was a concomitant increase in Runx2/Cbfa1. We also investigated the mechanism involved in the change in Runx2/Cbfa1 levels and whether the expression of other genes known to be involved in bone formation was altered. There was a decrease in Gsalpha expression with osteogenic differentiation and antisense oligonucleotides, and protein kinase A inhibition led to increased expression and DNA binding of the osteoblast-specific Runx2/Cbfa1. Additionally, with decreased Gsalpha expression or protein kinase A inhibition, Runx2/Cbfa1 protein was serine phosphorylated and ubiquitinated less. Microarray analysis, after the addition of antisense Gsalpha, showed a more than 10-fold increase in collagen Type I Alpha 2 mRNA (a target of Runx2/Cbfa1). These data show that reduced expression of Gsalpha can induce an osteoblast-like phenotype. The results also indicate a potential pathophysiologic role in patients with heterozygous inactivating mutations in GNAS1, the gene for the alpha chain (Gsalpha) of the heterotrimeric G protein, present in three disorders with ectopic intramembranous bone: Albright's hereditary osteodystrophy, progressive osseous heteroplasia, and osteoma cutis.
Efficient Class II Major Histocompatibility Complex Presentation of Endogenously Synthesized Hepatitis C Virus Core Protein by Epstein-Barr Virus-Transformed B-Lymphoblastoid Cell Lines to CD4<sup>+</sup>T Cells (1998)

The induction of an efficient CD4(+) T-cell response against hepatitis C virus (HCV) is critical for control of the chronicity of HCV infection. The ability of HCV structural protein endogenously expressed in an antigen-presenting cell (APC) to be presented by class II major histocompatibility complex molecules to CD4(+) T cells was investigated by in vitro culture analyses using HCV core-specific T-cell lines and autologous Epstein-Barr virus-transformed B-lymphoblastoid cell lines (B-LCLs) expressing structural HCV antigens. The T- and B-cell lines were generated from peripheral blood mononuclear cells derived from HCV-infected patients. Expression and intracellular localization of core protein in transfected cells were determined by immunoblotting and immunofluorescence. By stimulation with autologous B-LCLs expressing viral antigens, strong T-cell proliferative responses were induced in two of three patients, while no substantial stimulatory effects were produced by B-LCLs expressing a control protein (chloramphenicol acetyltransferase) or by B-LCLs alone. The results showed that transfected B cells presented mainly endogenously synthesized core peptides. Presentation of secreted antigens from adjacent antigen-expressing cells was not enough to stimulate a core-specific T-cell response. Only weak T-cell proliferative responses were generated by stimulation with B-LCLs that had been pulsed beforehand with at least a 10-fold-higher amount of transfected COS cells in the form of cell lysate, suggesting that presentation of antigens released from dead cells in the B-LCL cultures had a minimal role. Titrating numbers of APCs, we showed that as few as 10(4) transfected B-LCL APCs were sufficient to stimulate T cells. This presentation pathway was found to be leupeptin sensitive, and it can be blocked by antibody to HLA class II (DR). In addition, expression of a costimulatory signal by B7/BB1 on B cells was essential for T-cell activation.
The Clinical Pathologist (1940)

The Clinical Pathologist Get access L. W. Larson L. W. Larson Bismarck, North Dakota Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 10, Issue 7, 1 July 1940, Pages 425–430, https://doi.org/10.1093/ajcp/10.7.425 Published: 01 July 1940
Enabling Rack-scale Confidential Computing using Heterogeneous Trusted Execution Environment (2020)

With its huge real-world demands, large-scale confidential computing still cannot be supported by today's Trusted Execution Environment (TEE), due to the lack of scalable and effective protection of high-throughput accelerators like GPUs, FPGAs, and TPUs etc. Although attempts have been made recently to extend the CPU-like enclave to GPUs, these solutions require change to the CPU or GPU chips, may introduce new security risks due to the side-channel leaks in CPU-GPU communication and are still under the resource constraint of today's CPU TEE.To address these problems, we present the first Heterogeneous TEE design that can truly support large-scale compute or data intensive (CDI) computing, without any chip-level change. Our approach, called HETEE, is a device for centralized management of all computing units (e.g., GPUs and other accelerators) of a server rack. It is uniquely designed to work with today's data centres and clouds, leveraging modern resource pooling technologies to dynamically compartmentalize computing tasks, and enforce strong isolation and reduce TCB through hardware support. More specifically, HETEE utilizes the PCIe ExpressFabric to allocate its accelerators to the server node on the same rack for a non-sensitive CDI task, and move them back into a secure enclave in response to the demand for confidential computing. Our design runs a thin TCB stack for security management on a security controller (SC), while leaving a large set of software (e.g., AI runtime, GPU driver, etc.) to the integrated microservers that operate enclaves. An enclaves is physically isolated from others through hardware and verified by the SC at its inception. Its microserver and computing units are restored to a secure state upon termination.We implemented HETEE on a real hardware system, and evaluated it with popular neural network inference and training tasks. Our evaluations show that HETEE can easily support the CDI tasks on the real-world scale and incurred a maximal throughput overhead of 2.17% for inference and 0.95% for training on ResNet152.
Accurate internal camera calibration using rotation, with analysis of sources of error (2002)

Describes a simple and accurate method for internal camera calibration based on tracking image features through a sequence of images while the camera undergoes pure rotation. A special calibration object is not required and the method can therefore be used both for laboratory calibration and for self calibration in autonomous robots. Experimental results with real images show that focal length and aspect ratio can be found to within 0.15 percent, and lens distortion error can be reduced to a fraction of a pixel. The location of the principal point and the location of the center of radial distortion can each be found to within a few pixels. We perform a simple analysis to show to what extent the various technical details affect the accuracy of the results. We show that having pure rotation is important if the features are derived from objects close to the camera. In the basic method accurate angle measurement is important. The need to accurately measure the angles can be eliminated by rotating the camera through a complete circle while taking an overlapping sequence of images and using the constraint that the sum of the angles must equal 960 degrees.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Automated high-resolution polymerase chain reaction fragment analysis: a method for detecting T-cell receptor gamma-chain gene rearrangements in lymphoproliferative diseases. (1998)

Southern blot analysis and the polymerase chain reaction (PCR) are powerful tools for detecting clonal antigen receptor gene rearrangements. However, a number of limitations restrict the predictive value of the results obtained by these techniques as they are commonly used. We describe a new method, automated high-resolution PCR fragment analysis, that can partially overcome many of the limitations of analyzing the T-cell receptor (TCR) gamma-chain gene. Analysis of TCR-gamma is performed using PCR with four sets of primers, previously described by others, specific for all variable (V) and joining (J) regions of the TCR gamma-chain gene. In addition, the four V region primers are 5' end-labeled with a fluorescent compound, 5-carboxyfluorescein. After amplification, the labeled PCR products are separated with an automated sequencing system, ABI 373 (Applied Biosystems, Weiterstadt, Germany). With the help of the Gene-Scan software ABI 672 (Applied Biosystems) and fluorescent-labeled DNA length markers, the exact size of each peak can be displayed and analyzed. The resolution of this method allows separation of PCR products differing in length by as little as 1 bp. Semiquantitative estimation of specific clones also can be performed. Infiltrate-specific gene rearrangement patterns can be identified and recognized in different tissue specimens at the time of diagnosis or in subsequent biopsy specimens. We conclude that automated high-resolution PCR fragment analysis allows more accurate and convenient analysis of the TCR gamma-chain gene.
Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016 (2018)

Chronic pain, one of the most common reasons adults seek medical care (1), has been linked to restrictions in mobility and daily activities (2,3), dependence on opioids (4), anxiety and depression (2), and poor perceived health or reduced quality of life (2,3). Population-based estimates of chronic pain among U.S. adults range from 11% to 40% (5), with considerable population subgroup variation. As a result, the 2016 National Pain Strategy called for more precise prevalence estimates of chronic pain and high-impact chronic pain (i.e., chronic pain that frequently limits life or work activities) to reliably establish the prevalence of chronic pain and aid in the development and implementation of population-wide pain interventions (5). National estimates of high-impact chronic pain can help differentiate persons with limitations in major life domains, including work, social, recreational, and self-care activities from those who maintain normal life activities despite chronic pain, providing a better understanding of the population in need of pain services. To estimate the prevalence of chronic pain and high-impact chronic pain in the United States, CDC analyzed 2016 National Health Interview Survey (NHIS) data. An estimated 20.4% (50.0 million) of U.S. adults had chronic pain and 8.0% of U.S. adults (19.6 million) had high-impact chronic pain, with higher prevalences of both chronic pain and high-impact chronic pain reported among women, older adults, previously but not currently employed adults, adults living in poverty, adults with public health insurance, and rural residents. These findings could be used to target pain management interventions.
Systemic Disease-Induced Salivary Biomarker Profiles in Mouse Models of Melanoma and Non-Small Cell Lung Cancer (2009)

Taken together, our data support the conclusion that upon systemic disease development, significant changes can occur in the salivary biomarker profile. Although the origins of the disease-induced salivary biomarkers may be both systemic and local, stimulation of salivary gland by mediators released from remote tumors plays an important role in regulating the salivary surrogate biomarker profiles.
Multi-purpose Impedance-based Measurement System to Automate Microinjection of Adherent Cells (2005)

This paper presents a multi-purpose measurement system developed to automate cellular microinjection. The system is based on measuring impedance between an injection solution in an injection capillary and cell culture medium where cells grow. The system can be used for detecting a contact between a cell and the injection capillary, a broken capillary, a clogged capillary, an aged measurement electrode and faulty injection solution. The measurement system facilitates the development of an expert system for guiding cellular injections, and later a fully automatic microinjection system.
Occupational contact urticaria caused by cyclic acid anhydrides (2009)

Contact urticaria may be more common than previously believed. Prick tests with HSA-acid anhydride conjugates were a useful test method for detecting immediate sensitization to acid anhydrides. The determination of the specific IgE gave almost equal results. The open application test often had to be performed with the undiluted anhydride product to obtain a positive test result.
An analysis and experimental approach to MOS controlled diodes behavior (2000)

The metal oxide semiconductor (MOS)-controlled diode (MCD) is a new class of power semiconductor diode that can achieve ideal diode performance. In this paper, experimental verification of the MCD key concept is presented for the first time by using commercially available power metal oxide semiconductor field effect transistors (MOSFETs) operating as MCDs. Measurements of the reverse recovery currents and reverse recovery charges of these "MCDs" are obtained and compared with the body diodes of the MOSFETs. These measurements suggest that MCDs can reduce the reverse recovery current, storage charge, and switching loss significantly. Optimized MCD performances at 1.2 kV, 2.4 kV, and 4.5 kV are also predicted based on numerical simulations. Ideal performance of the MCD close to that predicted by the device simulation should be obtained once an optimized MCD is developed.
Impact of gene expression profiling-based risk stratification in patients with myeloma receiving initial therapy with lenalidomide and dexamethasone (2011)

Detection of specific chromosomal abnormalities by FISH and metaphase cytogenetics allows risk stratification in multiple myeloma; however, gene expression profiling (GEP) based signatures may enable more specific risk categorization. We examined the utility of 2 GEP-based risk stratification systems among patients undergoing initial therapy with lenalidomide in the context of a phase 3 trial. Among 45 patients studied at baseline, 7 (16%) and 10 (22%), respectively, were high-risk using the GEP70 and GEP15 signatures. The median overall survival for the GEP70 high-risk group was 19 months versus not reached for the rest (hazard ratio = 14.1). Although the medians were not reached, the GEP15 also predicted a poor outcome among the high-risk patients. The C-statistic for the GEP70, GEP15, and FISH based risk stratification systems was 0.74, 0.7, and 0.7, respectively. Here we demonstrate the prognostic value for GEP risk stratification in a group of patients primarily treated with novel agents. This trial was registered at www.clinicaltrials.gov as #NCT00098475.
Delayed Secondary Phase of Peri-Infarct Depolarizations after Focal Cerebral Ischemia: Relation to Infarct Growth and Neuroprotection (2003)

In focal cerebral ischemia, peri-infarct depolarizations (PIDs) cause an expansion of core-infarcted tissue into adjacent penumbral regions of reversible injury and have been shown to occur through 6 hr after injury. However, infarct maturation proceeds through 24 hr. Therefore, we studied PID occurrence through 72 hr after both transient and permanent middle cerebral artery occlusion (MCAo) via continuous DC recordings in nonanesthetized rats. PIDs occurred an average 13 times before reperfusion at 2 hr and then ceased for an average approximately 8 hr. After this quiescent period, PID activity re-emerged in a secondary phase, which reached peak incidence at 13 hr and consisted of a mean 52 PIDs over 2-24 hr. This phase corresponded to the period of infarct maturation; rates of infarct growth through 24 hr coincided with changes in PID frequency and peaked at 13 hr. In permanent MCAo, PIDs also occurred in a biphasic pattern with a mean of 78 events over 2-24 hr. Parameters of secondary phase PID incidence correlated with infarct volumes in transient and permanent ischemia models. The role of secondary phase PIDs in infarct development was further investigated in transient MCAo by treating rats with a high-affinity NMDA receptor antagonist at 8 hr after injury, which reduced post-treatment PID incidence by 57% and provided 37% neuroprotection. Topographic mapping with multielectrode recordings revealed multiple sources of PID initiation and patterns of propagation. These results suggest that PIDs contribute to the recruitment of penumbral tissue into the infarct core even after the restoration of blood flow and throughout the period of infarct maturation.