gebhart/patrepeval huggingface dataset:
Mechanism and function of changes in membrane-phospholipid asymmetry in platelets and erythrocytes (1993)

Conference Article| May 01 1993 Mechanism and function of changes in membrane-phospholipid asymmetry in platelets and erythrocytes Robert F. A. Zwaal; Robert F. A. Zwaal 1Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Limburg, P.O. Box 616, Maastricht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar Paul Comfurius; Paul Comfurius 1Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Limburg, P.O. Box 616, Maastricht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar Edouard M. Bevers Edouard M. Bevers 1Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Limburg, P.O. Box 616, Maastricht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (2): 248–253. https://doi.org/10.1042/bst0210248 Article history Received: November 20 1992 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Robert F. A. Zwaal, Paul Comfurius, Edouard M. Bevers; Mechanism and function of changes in membrane-phospholipid asymmetry in platelets and erythrocytes. Biochem Soc Trans 1 May 1993; 21 (2): 248–253. doi: https://doi.org/10.1042/bst0210248 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: DMPC, dimyristoylphosphatidylcholine This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
Passive perception system for day/night autonomous off-road navigation (2005)

Passive perception of terrain features is a vital requirement for military related unmanned autonomous vehicle operations, especially under electromagnetic signature management conditions. As a member of Team Raptor, the Jet Propulsion Laboratory developed a self-contained passive perception system under the DARPA funded PerceptOR program. An environmentally protected forward-looking sensor head was designed and fabricated in-house to straddle an off-the-shelf pan-tilt unit. The sensor head contained three color cameras for multi-baseline daytime stereo ranging, a pair of cooled mid-wave infrared cameras for nighttime stereo ranging, and supporting electronics to synchronize captured imagery. Narrow-baseline stereo provided improved range data density in cluttered terrain, while wide-baseline stereo provided more accurate ranging for operation at higher speeds in relatively open areas. The passive perception system processed stereo images and outputted over a local area network terrain maps containing elevation, terrain type, and detected hazards. A novel software architecture was designed and implemented to distribute the data processing on a 533MHz quad 7410 PowerPC single board computer under the VxWorks real-time operating system. This architecture, which is general enough to operate on N processors, has been subsequently tested on Pentium-based processors under Windows and Linux, and a Sparc based-processor under Unix. The passive perception system was operated during FY04 PerceptOR program evaluations at Fort A. P. Hill, Virginia, and Yuma Proving Ground, Arizona. This paper discusses the Team Raptor passive perception system hardware and software design, implementation, and performance, and describes a road map to faster and improved passive perception.
Auxetic Cellular Materials - a Review (2016)

Auxetic cellular materials are modern materials which have some unique and superior mechanical properties. As a consequence of the structural deformation of their internal cellular structure they exhibit a negative Poisson's ratio, i.e. they significantly increase in volume when stretched and vice versa. The effect of negative Poisson's ratio is useful in many applications to enhance certain physical properties such as the density, stiffness, fracture toughness, energy absorption and damping. These properties can be further tailored by using variable cell geometry and density distribution, which can be achieved with functionally graded porosity of auxetic materials. This review paper provides the state-of-the-art overview of the auxetic materials, their development, most common geometries, fabrication methods, mechanical properties, applications and further possibilities for their development.
Solving Global Cybersecurity Problems by Connecting Trust Using Blockchain (2018)

This publication explores global problem areas where properties offered by Blockchain provide workable solutions for the existing widely unsolved problems of Accountability, Traceability, Identification, Visibility vs. Privacy, and Connection of Non-Deterministic to Deterministic timed events. Using BlockChain-based transactions, we demonstrate that operations related to trust are reducible to five directly implementable cryptographic actions, which then create relationships to five categories of trust that we define in this document. The solution outlined will take the approach that the identified global problems will be solved by blockchain as cybersecurity of the future moves in a direction of individualized transactional-based security & privacy. Developers and organizations looking to implement new solutions or integrate blockchain into existing applications would be interested in this publication. Methods described provide workable solutions for implementing trust relationships using blockchain for positive use cases which can be related directly to cyber security industry solutions.
The cognitive jogthrough (1992)

Walkthrough techniques have been shown to be an effective supplement to empirical testing methods for evaluating the usability of software systems [3, 4]. Unfortunately, structured walkthrough procedures tend to be time-consuming and unpopular with evaluators when used on substantial tasks. To maximize the useful information obtained from walkthroughs while minimizing the overhead of the procedure itself, a fast-paced methodology was developed and used within the constraints of a real-world product development environment. By using video recording equipment and an informal, interactive evaluation session, the “cognitive jogthrough” procedure revealed significant user interface problems that could then be studied using other techniques.
Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders (2016)

Mood disorders, including anxiety and depression, are thought to be characterized by disrupted neuronal synapses and altered brain plasticity. The etiology is complex, involving numerous regions of the brain, comprising a multitude of neurotransmitter and neuromodulator systems. Recently, new studies on the teneurins, an evolutionary ancient family of type II transmembrane proteins have been shown to interact with latrophilins (LPHN), a similarly phylogenetically old family of adhesion G protein-coupled receptors (GPCR) forming a transsynaptic adhesion and ligand-receptor pair. Each of the four teneurin proteins contains bioactive sequences termed the teneurin C-terminal associated peptides (TCAP-1-4), which possess a number of neuromodulatory effects. The primary structures of the TCAP are most closely similar to the corticotropin-releasing factor (CRF) family of peptides. CRF has been implicated in a number of diverse mood disorders. Via an association with dystroglycans, synthetic TCAP-1 administration to both embryonic and primary hippocampal cultures induces long-term changes in neuronal structure, specifically increased neurite outgrowth, dendritic branching, and axon growth. Rodent models treated with TCAP-1 show reduced anxiety responses in the elevated plus-maze, openfield test, and acoustic startle test and inhibited CRF-mediated cocaine-seeking behaviour. Thus the teneurin/TCAP-latrophilin interaction may play a major role in the origin, development and treatment of mood disorders.
Effect of protein properties on display efficiency using the M13 phage display system. (2008)

The M13 phage display system is a powerful technology for engineering proteins such as functional mutant proteins and peptides. In this system, it is necessary that the protein is displayed on the phage surface. Therefore, its application is often limited when a protein is poorly displayed. In this study, we attempted to understand the relationship between a protein's properties and its display efficiency using the well-known pIII and pVIII type phage display system. The display of positively charged SV40 NLS and HIV-1 Tat peptides on pill was less efficient than that of the neutrally charged RGDS peptide. When different molecular weight proteins (1.5-58 kDa) were displayed on pIII and pVIII, their display efficiencies were directly influenced by their molecular weights. These results indicate the usefulness in predicting a desired protein's compatibility with protein and peptide engineering using the phage display system.
Measures and metrics (2010)

Abstract If we know the structure of a network we can calculate from it a variety of useful quantities or measures that capture particular features of the network topology. This chapter looks at some of these measures, including degree centrality, eigenvector centrality, Katz centrality, transitivity, reciprocity, and similarity. Exercises are provided at the end of the chapter.
Synthetic Testing and Interrupting Phenomena Under Short Line Fault Conditions (1972)

This paper is a contribution to work on the problems of synthetic testing under short line fault conditions. The various factors which must be taken into account when assessing validity are discussed, and the experimental evidences to support the validity of the parallel current injection method are described. The paper also deals with the severest current range in short line fault conditions for different types of circuit breakers.
The Restricted Expression of Granzyme M in Human Lymphocytes (2001)

We have analyzed the expression of human granzyme M (Gzm M) in various human leukocyte subsets using the specific mAb 4H10. Using FACS and Western blotting analysis we compared the expression of Gzm M with that of other granzymes (Gzm A and Gzm B) and the lytic protein perforin. Human Gzm M was constitutively highly expressed in NK cells as was perforin and Gzm A. Surprisingly, freshly isolated NK cells had very low (sometimes undetectable) levels of Gzm B. In contrast to Gzm B and perforin, Gzm M was not detected in highly purified CD4(+) and CD8(+) T cells either constitutively or after short term activation in vitro. However, low levels of Gzm M were observed in some T cell clones on prolonged passage in vitro. Gzm M was not detected in highly purified neutrophils, monocytes, or tumor cells of the myelomonocytic lineage. Examination of minor T cell subsets from human peripheral blood showed detectable Gzm M in CD3(+), CD56(+) T cells and gammadelta T cells. A histological staining procedure was developed that demonstrated a granular staining pattern for Gzm M and a cellular distribution similar to that observed by Western blotting. These data indicate that the expression of Gzm M does not always correlate with the lytic activity of cytotoxic cells. However, expression of Gzm M in NK cells, CD3(+), CD56(+) T cells, and gammadelta T cells suggests that this enzyme may play some role in innate immune responses.
Involvement of <i>ZFR1</i> of <i>Fusarium verticillioides</i> in kernel colonization and the regulation of <i>FST1</i> , a putative sugar transporter gene required for fumonisin biosynthesis on maize kernels (2008)

Fumonisins comprise a class of carcinogenic mycotoxins produced by Fusarium verticillioides during colonization of maize kernels. In previous work, we identified ZFR1, which is predicted to encode a Zn(II)2Cys6 zinc finger transcription factor required for fumonisin B(1) (FB(1)) production during growth on kernels. In this study, we characterized the role of ZFR1 in colonizing maize kernels and inducing FB(1) biosynthesis. The ZFR1 deletion strain (Deltazfr1) grew approximately 2.5-fold less than the wild-type on endosperm tissue and a variety of other carbon sources, including glucose and amylopectin. However, the Deltazfr1 strain displayed higher alpha-amylase activity and expression of genes involved in starch saccharification than the wild-type, thus indicating that the reduced growth of the Deltazfr1 strain was not due to inhibition of amylolytic enzymes. In the wild-type strain, expression of six genes encoding putative sugar transporters was significantly greater on endosperm tissue than on germ tissue, and expression of at least three of the six genes was negatively affected by disruption of ZFR1. Intriguingly, disruption of FST1 had no effect on growth, kernel colonization or kernel pH but decreased FB(1) production by approximately 82% on maize kernels. Based on these findings, we hypothesize that ZFR1 controls FB(1) biosynthesis by regulating genes involved in the perception or uptake of carbohydrates.
A compact rotating-mirror autocorrelator design for femtosecond and picosecond laser pulses (1998)

An interferometric rapid-scanning autocorrelator employing two antiparallel rotating mirrors in a variable arm is optimized for maximum optical path difference as a function of the separation of the two rotating mirrors. A very compact design (mirror separation≈mirror diameter) is possible without a reduction in the maximum pulse width that can be measured.
A proposal for early warning indicators to detect impending metallization failure of DMOS transistors in cyclic operation (2015)

DMOS transistors in integrated smart power technologies are often subject to cyclic power dissipation with substantial self-heating. This leads to repetitive thermo-mechanical stress, causing fatigue of the on-chip metallization and limiting the lifetime. Hence, most designs use large devices for lower peak temperatures and thus reduced stress to avoid premature failures. However, significantly smaller DMOS transistors are acceptable if the system reverts to a safer operating condition with lower stress when a failure is expected to occur in the near future. Hence, suitable early-warning sensors are required. This paper proposes a floating metal meander embedded between DMOS source and drain to detect an impending metallization failure. Measurement results of several variants will be presented and discussed, investigating their suitability as early warning indicators.
[Acceleration of the regeneration of skeletal muscles in adult rats by dextran derivatives]. (1995)

Dextran derivatives were obtained by controlled successive substitutions of carboxymethyl, carbomethyl-benzylamide and carboxymethyl-benzylamide sulfonate groups on glucose residues. Among these derivatives, RGT11 was selected since it mimicked some properties of heparin or heparan sulfate to stabilise and protect heparin binding growth factors such as FGFs and TGF-beta. Furthermore RGT11 inhibited plasmine and leukocyte elastase. In previous works, we have explained the healing effects of RGT obtained in skin or bone repair models by these protecting and inhibiting properties. We now present the results obtained after a single injection of RGT11 in a regenerating crushed extensor digitorum longus (EDL) muscle. After 8 days, RGT11 injected muscles contained 10 times the number of fibers than controlled injected muscles. Fibers were organized in bundles of normal size. Histological analysis indicated that regeneration was comparable to that observed after 3 weeks without RGT. Hence in vivo, RGT11 could act by protecting the heparin binding growth factors involved in the natural process of muscle regeneration and therefore favour their actions. This family of polymers should offer a new pharmaceutical potential for treating muscle atrophy and destruction and is worth studying further.
Fluorescence polarisation immunoassay based on a monoclonal antibody for the detection of sulphamethazine in chicken muscle (2006)

Summary A fluorescence polarisation immunoassay (FPIA) for the screening of sulphamethazine (SMZ) in chicken muscle was developed. Fluorescein‐labelled tracers for several sulphonamides were synthesised and monoclonal antibodies (Mabs) and polyclonal antibody (Pab) were produced. The Mabs and Pabs were raised against sulphonamides conjugated to bovine serum albumin by a diazo method. The most sensitive FPIA method for SMZ detection was based on a combination of the Mab against SMZ–bovine serum albumin and tracer SMZ labelled with fluorescein isothiocyanate. The limit of detection and IC 50 for SMZ were 1 and 16 ng mL −1 . Recoveries of SMZ from fortified chicken muscle samples averaged between 78% and 89%. The proposed FPIA method was applied for determining SMZ in an actual residue study.
A fuzzy-neural approach to real time plasma boundary reconstruction in tokamak reactors (2002)

A novel plasma shape identification procedure based on both neural network (NN) and fuzzy system (FS) approaches is presented. The derived processor takes firstly advantage of the fuzzy curves (FCs) concept for carrying out a guided dimensionality reduction of the available pattern of measurements (inputs of the reconstruction procedure). The mapping between the input pattern and the corresponding set of parameters describing the plasma (outputs of the procedure) is then approximated by a FS whose bank of rules is directly extracted from the relevant FCs. An extremely simplified NN is finally trained to learn the estimation error of the above mentioned fuzzy block. One of the most relevant consequences of the analysis carried out on the first phase is the possibility of using a very limited number of measurements for correcting the mapping. This may have an impact on both the rapidity of the identification in real time and the reduction of the number of sensors required to achieve a prescribed accuracy for control. As a by-product, the designed fuzzy-neural system reduces the extrapolation problems typically encountered by the researchers when using simple NN models.
Melbourne @ 5 Million and the Victorian Transport Plan: A Short Summary (2009)

The key aspects and features of the Melbourne @ 5 million and the Victorian Transport Plan are discussed. The plan's approach is to adopt a 'polycentric' metropolitan structure, with six new Central Activities Districts (CADs) counterbalancing the existing Melbourne CBD.
Stability of tidal inlets: use of hydraulic pressure for channel and bypassing stability (1988)

This paper reviews briefly existing procedures and methods of channel stabilization and bypassing. The objective in all cases is to achieve an even, non-interrupted stability of the channel in its full length and a reliable, continuous and economical bypassing which retains an essential part of the longshore drift material. Modulation of inlet sub-bottom hydraulic pressures are shown to increase bed load transport, to create major offshore traps, and to transport sand by fluidization to bypassing pumps.
A volume rendering method based on multiple segmentation results (2010)

Most volume renderings in medical application today employ one-dimensional transfer functions, which assign color and opacity to samples solely on their intensity value. The method is not effective when it is used on volumes that contain different materials sharing some common value range. The current method using multi-dimensional transfer function based on the introduction of gradient magnitude can achieve a better classified rendering result, but the implementation of the method depends on a relatively complex user-interface. An alternative method will be introduced in this article, which first takes advantage of multiple segmentation results to map the value of different materials to separate intervals, and then render the resulting volume with a typical rendering module using one-dimensional transfer functions. A clear contrast between different tissues can be achieved by setting the transfer functions by pieces according to the gray intervals standing for different materials. The implementation and the usage of the method are both quite simple.
Experimental Retinal Detachment (1984)

Unilateral chronic rhegmatogenous retinal detachments were produced in eight cynomolgus monkeys. Fellow eyes underwent total vitrectomy. Aqueous-plasma and vitreous-plasma ratios of fluorescein isothiocyanate-dextran (70,000 molecular weight) after intravenous administration were less than 0.004 in detached and fellow eyes. Intravitreal injection of fluorescein isothiocyanate-dextran in detached eyes passed into the subretinal space at a rate of 1.12 microL/min, where it was visibly sequestered for months. In fellow eyes, fluorescein isothiocyanate-dextran moved slowly from the vitreous cavity into the anterior chamber. The aqueous flow through the anterior chamber was lower in detached eyes. It is concluded that in eyes with rhegmatogenous retinal detachment, a flow of fluid exits from the posterior chamber, through the vitreous humor and retinal hole, into the subretinal space, and across the retinal pigment epithelium.
[4 + 2] Cycloaddition Reactions Catalyzed by a Chiral Oxazaborolidinium Cation. Reaction Rates and Diastereo-, Regio-, and Enantioselectivity Depend on Whether Both Bonds Are Formed Simultaneously (2010)

The reaction rates and products in enantioselective Diels-Alder reactions with a range of dienophiles correlate with the expected degree of concertedness of bond formation in the transition state.