gebhart/patrepeval huggingface dataset:
Novel polyfluoroalkylated pyrazoles from 2-polyfluoroacylcycloalkanones and hydrazines: syntheses and unequivocal molecular structure assignment (2001)

The reaction between 2-trifluoroacetylcycloalkanones and methylhydrazine or phenylhydrazine exclusively yields 3-CF 3 -pyrazoles. When the chain length of the polyfluorinated substituent in R F C(O) group increases, 5-R F -pyrazoles are isolated. The reaction of 2-trifluoroacetylcyclohexanone with 2-hydrazinopyradine gives 5-hydroxypyrazoline, an intermediate in the formation of 5-CF 3 -pyrazoles. The regiochemistry of the condensation is probably controlled by the nucleophilicity of the terminal nitrogen in the mono substituted hydrazines and by the steric requirements of the R F group in the 1,3-diketones. Polymethylene chain containing pyrazoles obtained from the 1,3-diketones in question and hydrazine prefer the 3-R F tautomeric form, irrespective of carbocyclic ring size and polyfluoroalkyl group chain length.Key words: polyfluorinated 1,3-diketones, hydrazines, isomeric pyrazoles, molecular structure.
The Electrodeposition of Aluminum from Aromatic Hydrocarbon: I . Composition of Baths and the Effect of Additives (1976)

Electroplating of aluminium on copper and steel substrates was conducted at room temperature. The bath consisted basically of and an alkali metal bromide such as dissolved in a suitable mixture of aromatic hydrocarbons. The bath was operated under conditions resembling industrial operation. Oxygen and humidity were removed by bubbling nitrogen through the bath. The effect of bath composition on the quality of the plated product is discussed in detail. Transference numbers were measured. The aluminium is shown to be present in the form of a negative ion , the transference number of which is larger than that of the solvated positive ion. The reactions taking place during deposition and dissolution of aluminium in this system are discussed in detail.
An efficient multicast routing algorithm for delay-sensitive applications with dynamic membership (2002)

We propose an algorithm for finding a multicast tree in packet-switched networks. The objective is to minimize total cost incurred at the multicast path. The routing model is based on the minimum cost Steiner tree problem. The Steiner problem is extended to incorporate two additional requirements. First, the delay experienced along the path from the source to each destination is bounded. Second, the destinations are allowed to join and leave multicasting anytime during a session. To minimize the disruption to on-going multicasting the algorithm adopts the idea of connecting a new destination to the current multicasting by a minimum cost path satisfying the delay bound. To find such a path is an NP-hard problem and an enumerative method relying on generation of delay bounded paths between node pairs is not likely to find a good routing path in acceptable computation time when network size is large. To cope with such difficulty, the proposed algorithm utilizes an optimization technique called Lagrangian relaxation method. A computational experiment is done on relatively dense and large Waxman's networks. The results seem to be promising. For sparse networks, the algorithm can find near-optimal multicast trees. Also the quality of multicast trees does not seem to deteriorate even when the network size grows. Furthermore, the experimental results shows that the computational efforts for each addition of node to the call are fairly moderate, namely the same as to solve a few shortest path problems.
Insulin given intranasally induces hypoglycaemia in normal and diabetic subjects. (1982)

Regular or crystalline insulin with sodium glycocholate as surfactant administered intranasally to normal volunteers induced hypoglycaemia and an increase in serum immunoreactive insulin concentrations. Serum C-peptide concentrations decreased or remained unchanged. Insulin administered intravenously to three of these subjects yielded a potency ratio of 1:8 for intranasal and intravenous insulin. In four insulin-dependent diabetics a cross-over study was performed on different days, insulin being administered once intranasally and once subcutaneously in a ratio of 1:9. In these patients the intranasal insulin was more effective than the subcutaneous insulin in preventing hyperglycaemia after breakfast. In four other insulin-dependent diabetics 11-hours monitoring was performed twice on two different days, insulin being administered in divided dosage sufficient to achieve a reasonable glycaemic profile. The administration during the morning, whereas subcutaneous insulin was more effective than intranasal during the afternoon.
Hollow cylindrical waveguides for use as evanescent fluorescence-based sensors: effect of numerical aperture on collected signal (1997)

Hollow cylindrical waveguide sensors permit conventional capillary injection techniques for flowing precise volumes of a liquid sample through the sensor while exciting and collecting fluorescence by use of evanescent fields. Both a ray-optics model and experimental data show that fluorescence collected from bulk or thin-layer fluorescent samples increases strongly as the numerical aperture (N.A.) increases and is maximized when the N.A. of the excitation-collection optics matches the waveguide N.A. The dependence of fluorescence on N.A. closely resembled that reported previously for solid cylindrical waveguides. Mode mixing reduced the strength of this dependence and should be minimized to increase collected fluorescence.
Human Rights Within the World Legal Order: A Reply to Sohn and McDougal (1982)

Professor Sohn is the quintessential charterist. He views the world legal order, at least as it pertains to human rights, as being a centralized structure with the United Nations Charter as its base. "The Charter is the cornerstone of international jus cogens, and its provisions prevail over all other international and domestic legislative acts." According to Sohn, the Charter creates a variety of human rights norms and authorizes their implementation and enforcement through various United Nations organs: "These provisions express clearly the obligations of all members and the powers of the organization in the field of human rights. While the provisions are general, nevertheless they have the force of positive international law and create basic duties which all members must fulfil in good faith. Moreover, any concern one might have about the generality of the Charter provisions is resolved by the Universal Declaration of Human Rights, which, Sohn concludes, "not only constitutes an authoritative interpretation of the Charter obligations but also a binding instrument in its own right, representing the consensus of the international community on the human rights which each of its members must respect, promote and observe."' Finally, in order to resolve any lingering doubt as to the reality of his claims, Sohn informs us that "[t]he practice of the United Nations confirms this conclusion, citing as evidence various resolutions of the United Nations condemning human rights violations. ...\nProfessor McDougalF shares, at least in part, Professor Sohn's optimistic view of the status of human rights within the world legal order. He claims that there presently exists\nan immense body of prescriptions-beginning with the United Nations Charter and extending through the Universal Declaration of Human Rights to the two major international covenants and numerous more specialized and ancillary formulations-which have taken on both the substance and form of the basic bills of rights long established and maintained in national communities.\nThese prescriptions, according to McDougal, await only the perfection of institutions and procedures for implementation: "The structures and procedures for applying and sanctioning these human rights prescriptions, as for other prescriptions, remain imperfect, but continuous improvement is being made in such structures and procedures ....
Transcatheter Splenic Arterial Occlusion: An Experimental Study in Dogs (1977)

Three techniques of transcatheter splenic arterial occlusion were evaluated in dogs. Angiographic, hematologic, and morphologic studies were done up to 9 weeks postocclusion. All animals showed hematologic changes characteristic of depressed splenic function; the degree and duration of these changes depended upon the technique. Alterations in histology including vascular congestion, infarction, and fibrosis, were also dependent upon the method used and the time elapsed after occlusion. Celiac angiography demonstrated the extent of collateral circulation and degree of recanalization of the occluded vessels. Potential clinical applications are discussed.
A Theoretical Framework for Conversational Search (2017)

This paper studies conversational approaches to information retrieval, presenting a theory and model of information interaction in a chat setting. In particular, we consider the question of what properties would be desirable for a conversational information retrieval system so that the system can allow users to answer a variety of information needs in a natural and efficient manner. We study past work on human conversations, and propose a small set of properties that taken together could measure the extent to which a system is conversational. Following this, we present a theoretical model of a conversational system that implements the properties. We describe how this system could be implemented, making the action space of an conversational search agent explicit. Our analysis of this model shows that while theoretical, the model could be practically implemented to satisfy the desirable properties presented. In doing so, we show that the properties are also feasible.
Formation, optical properties, and laser operation of F−2 centers in LiF (1987)

Formation conditions, optical properties, and lasing behavior of F−2 color centers in LiF crystals are investigated. The optical pumping cycle of the three-electron defect is found to involve intermediate transitions of small efficiency into some metastable energy levels (having a lifetime of several seconds). This process could either be intrinsic to the F−2 defects (e.g., intersystem crossing into quartet states) or it could be caused by (low efficiency) optical ionization of F−2 centers and electron capture in unstable traps. While cw laser oscillation is prevented by a resulting bottleneck, efficient tunable pulsed laser operation in the 1.1–1.2-μm range is possible at room temperature.
NMR structures of proteins and protein complexes beyond 20,000 M(r). (1997)

Recent advances in multidimensional NMR to obtain resonance assignments, interproton distance and torsion angle restraints, and restraints that characterize long range order, coupled with new methods of structure refinement, have permitted solution structures of proteins in excess of 250 residues to be solved.
Alleviation of cytotoxic therapy-induced normal tissue damage. (1995)

Cytotoxic chemotherapy and radiation therapy damage normal body tissues, resulting in stomatitis, conjunctivitis, esophagitis, proctitis, and dermatitis. Pursuant to this, the North Central Cancer Treatment Group has developed a series of clinical trials designed to study antidotes for these pathologic processes. These trials have demonstrated clinically helpful therapies (eg, oral cryotherapy for decreasing mucositis induced by 5-fluorouracil) and also have demonstrated lack of benefit for other proposed treatments. Results from several ongoing clinical trials should become available in the near future.
A new method of standartization of health-promoting pomegranate fruit (Punica granatum) extract. (2006)

This study analyzes the major phenolic constituents of pomegranate fruit juice and pericarp feedstock, and dry extracts thereof, using high-performance liquid chromatography. Pomegranate pericarp was extracted with water (WE) and alcohol (AE) as solvents, and liquid extracts were subsequently freeze-dried. The results indicate that ellagitannins punicalagin A and punicalagin B are the major constituents in the primary pomegranate feedstock and in both types of extracts. Ellagic acid, a common botanical constituent that is currently used to standardize pomegranate extracts, as well as ellagitannin punicalin, were found to be only minor constituents. Total punicalagins (the sum of punicalagins A+B and punicalin) and ellagic acid content in the pomegranate fruit pericarp feedstock WE were 7,6+/-0,3% and 0,2+/-0,1% by dry weight, respectively, and in the AE feedstock 7,0+/-0,2 and 0,4+/-0,1%, respectively. Total phenolic content (the sum of punicalagins and ellagic acid) in the pomegranate WE and AE were 45,8+/-1,2% and 42,3+/-1,1%, respectively. The concentrations of ellagic acid in the pomegranate WE and AE were 0,8+/-0,2% and 3,9+/-0,2%, respectively. Total phenolics in fresh single-strength pomegranate whole fruit juice contained 2,216+/-70 mg/L (95% punicalagins), whereas commercial pomegranate juice that was purchased from local stores was 317+/-13 mg/L (70% punicalagins). Our results strongly suggest that the commercially produced pomegranate extracts should be standardized to the content of total punicalagins as well as ellagic acid. The current standard uses only ellagic acid, which is unreliable, potentially misleading and vulnerable to commercial adulteration.
Interdependent lateral interactions, hydrophobicity and acid strength and their influence on the catalytic activity of nanoporous sulfonic acid silicas (2010)

A series of propylsulfonic (MCM–SO3H) and octyl co-functionalised propylsulfonic (MCM–Oc–SO3H) catalysts have been prepared by post modification of MCM-41 with mercaptopropyltrimethoxysilane (MPTS) to achieve SO3H surface coverages spanning the range 0.12–1 monolayer. Within the MCM–Oc–SO3H series, samples with submonolayer MPTS coverages were further grafted with octyltrimethoxysilane to cap bare hydroxyl sites and tune the hydrophobicity of the support. For the MCM–SO3H series NH3 calorimetry revealed acid strength increases as a function of sulfonic acid loading, with -ΔHads(NH3) increasing from 87 to 118 kJ mol−1. In contrast, MCM–Oc–SO3H exhibits a dramatic enhancement of acid strength for submonolayer SO3H coverages, with -ΔHads(NH3) found to increase to 103 kJ mol−1. In line with these acid strength measurements the per-site activity of the MCM–SO3H series in the esterification of butanol with acetic acid was found to increase with SO3H content. Incorporation of octyl groups further promotes esterification activity of all the samples within the MCM–Oc–SO3H series, such that the turn over frequency of the sample with the lowest loading of SO3H more than doubles. Molecular dynamic simulations indicate that the interaction of isolated sulfonic acid groups with the pore walls is the primary cause of the decrease in acid strength and activity of submonolayer samples within the MCM–SO3H series. Incorporation of octyl groups results in a combination of increased hydrophobicity and lateral interactions between adjacent sulfonic acid head groups, resulting in a striking enhancement of acid strength and esterification activity.
Identification of mechanical parameters at low velocities for a micropositioning stage using a velocity hysteresis model (2012)

The paper presents a velocity hysteresis friction model. This model can be used for simulation or control of an accurate micropositioning servomechanism. The mechanical and friction parameters are identified from measured signals at low velocities, and with the use of a closed loop identification method. The measured signals are very noised. The number of measurement samples available is very low. The friction model depends on position, velocity and acceleration and includes the Coulomb, Stribeck and viscous frictions. A hysteresis effect integrated by an exponential term and the acceleration is added in the model. The identified parameters are validated by applying an efficient precision method based on the sensitivity analysis of nonlinear models and a normalized mean-square-error criterion.
Review of Cardiovascular Effects of Fluoxetine, A Selective Serotonine Reuptake Inhibitor, Compared to Tricyclic Antidepressants (1998)

Fluoxetine is an antidepressant drug, a potent and specific inhibitor of serotonin reuptake (SSRI). Evidence suggests that being compared with tricyclic antidepressants, fluoxetine may cause significantly fewer anticholinergic, antihistaminergic and cardiotoxic side effects in the treatment of major depressive disorders. Chronic treatment with fluoxetine was not reported to affect the electrocardiogram (ECG). There is no clinical evidence of conduction delay and very little evidence of orthostatic hypotension. In the overdosed patients fewer cardiac symptoms were reported than with tricyclic antidepressants. However, dysrhythmia (atrial fibrillation and bradycardia) and syncope associated with fluoxetine treatment and overdose were reported. Although such reports have not been common, they do raise concerns. Thus we investigated the direct cardiovascular effects of the fluoxetine in isolated heart preparations and vessels of rats and rabbits. From 10 -6 M to 10 -4 M concentrations fluoxetine showed cardiodepressant and vasodilatory effects. These effects were similar to those of previously reported on tricyclic compounds. This review is a brief summary of possible cardiovascular effects of fluoxetine and other new SSRis antidepressants from the literature based on experience of clinical studies and our experiments with fluoxetine on isolated rat and rabbit cardiac preparations and vessels. Possible explanations of the lower incidence of cardiovascular complications with fluoxetine in humans and cardiodepressant effects in vitro are discussed.
A polycaprolactone‐based syntactic foam with bidirectional reversible actuation (2017)

ABSTRACT A polycaprolactone (PCL) based syntactic foam was prepared by incorporating 40% by volume of glass microspheres and crosslinking the PCL matrix with benzyl peroxide. FTIR, differential scanning calorimeter, scanning electron microscopy, dynamic mechanical analysis, and material testing system were employed to elucidate the chemical, thermal, surface, and mechanical properties of the syntactic foam. This crosslinked PCL (cPCL) syntactic foam displayed a clear two‐way shape memory effect (2W‐SME). Specifically, around 10% elongation upon cooling and 10% contraction upon heating were observed for the system at selected external loads and temperature windows. Programming was shown to be the key parameter to tune a prominent 2W‐SME of the cPCL syntactic foam. With the combined physical/mechanical properties (low density, ductile, high compressive strength, water tightness, etc.), together with its bidirectional reversible actuation, the system developed may be good for broad applications in different fields such as biomedical devices, soft robots, aircrafts, and sealants. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45225.
Kinetic Inhibition Patterns of Neutral Glucosidase (1973)

Conference Article| January 01 1973 Kinetic Inhibition Patterns of Neutral Glucosidase MARY D. O'DONNELL; MARY D. O'DONNELL 1Department of Medicine and Therapeutics, University College, Dublin 4, Irish Republic Search for other works by this author on: This Site PubMed Google Scholar KEVIN F. McGEENEY KEVIN F. McGEENEY 1Department of Medicine and Therapeutics, University College, Dublin 4, Irish Republic Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1973) 1 (1): 266–269. https://doi.org/10.1042/bst0010266a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation MARY D. O'DONNELL, KEVIN F. McGEENEY; Kinetic Inhibition Patterns of Neutral Glucosidase. Biochem Soc Trans 1 January 1973; 1 (1): 266–269. doi: https://doi.org/10.1042/bst0010266a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1973 Biochemical Society1973 Article PDF first page preview Close Modal You do not currently have access to this content.
Attenuated <i>Salmonella enteritidis</i> E23 as a vehicle for the rectal delivery of DNA vaccine coding for HIV‐1 polyepitope CTL immunogen (2011)

This study is focusing on elucidation of the capacity of attenuated Salmonella enteritidis E23 (cya, crp) to serve as a vehicle for the rectal delivery of the DNA vaccine. Earlier for creation HIV-1 candidate DNA vaccine we have designed the polyepitope protein TCI (T-cell immunogen), which comprises over 80 CTL epitopes from subtype A, B and C HIV-1 proteins. The gene coding for TCI protein was used to construct the eukaryotic expression plasmid pcDNA-TCI. The attenuated S. enteritidis E23 was transformed by electroporation with recombinant plasmid pcDNA-TCI and the expression of the TCI gene was determined in vitro and in vivo. BALB/c mice were rectally immunized with S. enteritidis E23/pcDNA-TCI (10⁸ cfu) twice at 4 week interval. Bacteria were not pathogenic for mice and spontaneously eliminated from mice spleen and liver to 60 days post the immunization. Detectable antibodies were generated in 2 weeks after immunization and their level increased after second immunization. The results of INF-γ ELISpot show that mice immunized with S. enteritidis E23/pcDNA-TCI elicited HIV-specific cellular immune response. This study demonstrates that attenuated S. enteritidis E23 is an effective live vector for rectal delivery of the DNA vaccine pcDNA-TCI to generate humoral and T-cellular responses against HIV-1.
Evolving complete robots with CPPN-NEAT (2011)

This paper extends prior work using Compositional Pattern Producing Networks (CPPNs) as a generative encoding for the purpose of simultaneously evolving robot morphology and control. A method is presented for translating CPPNs into complete robots including their physical topologies, sensor placements, and embedded, closed-loop, neural network control policies. It is shown that this method can evolve robots for a given task. Additionally it is demonstrated how the performance of evolved robots can be significantly improved by allowing recurrent connections within the underlying CPPNs. The resulting robots are analyzed in the hopes of answering why these recurrent connections prove to be so beneficial in this domain. Several hypotheses are discussed, some of which are refuted from the available data while others will require further examination.
Impact of the top-electrode material on the permittivity of single-crystalline Ba0.7Sr0.3TiO3 thin films (2005)

We observed significant influence of the top-electrode material on the thickness and temperature dependences of the dielectric response of single-crystalline Ba0.7Sr0.3TiO3 thin-film capacitors. For SrRuO3∕Ba0.7Sr0.3TiO3∕SrRuO3 samples, the position of dielectric maximum shifts to lower temperatures with decreasing film thickness, whereas the samples with Pt top electrodes exhibit an opposite trend. Moreover, the apparent “interfacial” capacitance, extracted from the film-thickness dependence of dielectric response, is very different for these two types of samples and strongly depends on temperature. Experimental results are analyzed theoretically in light of the depolarizing-field and strain effects on the transition temperature and permittivity of ferroelectric films.