gebhart/patrepeval huggingface dataset:
Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness. (2000)

Although mood disorders have traditionally been conceptualized as "neurochemical disorders," considerable literature from a variety of sources demonstrates significant reductions in regional central nervous system (CNS) volume and cell numbers (both neurons and glia) in persons with mood disorders. It is noteworthy that recent advances in cellular and molecular biology have resulted in the identification of 2 novel, hitherto completely unexpected targets of lithium's actions, discoveries that may have a major impact on the future use of this unique cation in biology and medicine. Chronic lithium treatment has been demonstrated to markedly increase the levels of the major neuroprotective protein bc1-2 in rat frontal cortex, hippocampus, and striatum. Similar lithium-induced increases in bc1-2 are also observed in cells of human neuronal origin and are observed in rat frontal cortex at lithium levels as low as approximately 0.3 mM. Bc1-2 is widely regarded as a major neuroprotective protein, and genetic strategies that increase bc1-2 levels have demonstrated not only robust protection of neurons against diverse insults, but have also demonstrated an increase in the regeneration of mammalian CNS axons. Lithium has also been demonstrated to inhibit glycogen synthase kinase 3beta (GSK-3beta), an enzyme known to regulate the levels of phosphorylated tau and beta-catenin (both of which may play a role in the neurodegeneration observed in certain forms of Alzheimer's disease). Consistent with the increases in bc1-2 levels and inhibition of GSK-3beta, lithium has been demonstrated to exert robust protective effects against diverse insults both in vitro and in vivo. These findings suggest that lithium may exert some of its long-term beneficial effects in the treatment of mood disorders via underappreciated neurotrophic and neuroprotective effects. To date, lithium remains the only medication demonstrated to markedly increase bc1-2 levels in several brain areas; in the absence of other adequate treatments, an investigation of the potential efficacy of lithium in the long-term treatment of several neurodegenerative disorders is warranted. Additionally, we suggest that a reconceptualization of the use of lithium in mood disorders may be warranted-namely, that the use of lithium as a neurotrophic/neuroprotective agent should be considered in the long-term treatment of mood disorders, irrespective of the "primary" treatment modality being used for the condition.
Proposal of a Database Type and Aggregation Function for Accelerating Medical Genomics Study on RDBMS (2016)

Next generation sequencing (NGS) and the recent development of efficient algorithms for genomic analysis are contributing to the understanding of human genetic variation and thus to personalized medicine. Among those genomic analysis, disease-causal gene analysis that finds genes relevant to specific diseases has received much attention. In this paper, we present our work on extending the PostgreSQL open source relational database management system (RDBMS) to efficiently handle genomic analysis. We introduced a new genome data type and a genome type aggregation function that drastically improved the performance of a typical query for disease-causal gene analysis by a factor of 50 to 360.
CORDIC based algorithm for frequency offset estimation (2010)

This paper proposed a new Modified algorithm under the Vectoring Mode CORDIC algorithm called MVM-CORDIC algorithm, which is used to calculate the angle of frequency offset estimation in the communications system. From the simulation result, we can see that under the certain accuracy the MVM-CORDIC algorithm can reduce the iteration number by contrasting to the conventional CORDIC algorithm, meanwhile the total execution time of hardware implement of MVM-CORDIC is less than conventional CORDIC algorithm. Finally, MVM-CORDIC algorithm is implemented on Xilinx Virtex4 FPGA.
Hydroboration. XI. The Hydroboration of Acetylenes—A Convenient Conversion of Internal Acetylenes into cis-Olefins and of Terminal Acetylenes into Aldehydes (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydroboration. XI. The Hydroboration of Acetylenes—A Convenient Conversion of Internal Acetylenes into cis-Olefins and of Terminal Acetylenes into AldehydesHerbert C. Brown and George ZweifelCite this: J. Am. Chem. Soc. 1961, 83, 18, 3834–3840Publication Date (Print):September 1, 1961Publication History Published online1 May 2002Published inissue 1 September 1961https://pubs.acs.org/doi/10.1021/ja01479a024https://doi.org/10.1021/ja01479a024research-articleACS PublicationsRequest reuse permissionsArticle Views1483Altmetric-Citations179LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Procalcitonin in patients with acute myocardial infarction. (2002)

Acute myocardial infarction induces an inflammatory reaction. We related conventional inflammatory parameters including C-reactive protein, erythrocyte sedimentation rate, white blood cell count and axillary temperature to plasma concentrations of procalcitonin in patients with acute myocardial infarction. In a prospective-descriptive study, we evaluated 54 patients with acute myocardial infarction. During a time period of 8 days following myocardial infarction, C-reactive protein, erythrocyte sedimentation rate, white blood cell count and axillary temperature as well as the plasma concentrations of procalcitonin were measured. Maximal procalcitonin remained normal (below 0.5 microgram/L) in patients with uncomplicated acute myocardial infarction. This contrasted with results obtained from patients additionally afflicted by pulmonary edema and cardiogenic shock, in whom maximal procalcitonin increased up to 5.24 micrograms/L. Resuscitation after cardiac arrest and/or concomitant bacterial infection increased procalcitonin to a maximal value of 134 micrograms/L, which was independent of the severity of left heart failure. Conventional inflammatory parameters were all significantly increased even in the absence of cardiac and non-cardiac complications of acute myocardial infarction. In conclusion, procalcitonin increases in patients with acute myocardial infarction only if associated with severe left heart failure, resuscitation after cardiac arrest or in the presence of bacterial infections. Thus, procalcitonin may help to elucidate the etiology of systemic inflammatory response during the early course of acute myocardial infarction.
Nitridation and Layered Assembly of Hollow TiO<sub>2</sub> Shells for Electrochemical Energy Storage (2013)

The nitridation of hollow TiO 2 nanoshells and their layered assembly into electrodes for electrochemical energy storage are reported. The nitridated hollow shells are prepared by annealing TiO 2 shells, produced initially using a sol–gel process, under an NH 3 environment at different temperatures ranging from 700 to 900 °C, then assembled to form a robust monolayer film on a water surface through a quick and simple assembly process without any surface modification to the samples. This approach facilitates supercapacitor cell design by simplifying the electrochemical electrode structure by removing the need to use any organic binder or carbon‐based conducting materials. The areal capacitance of the as‐prepared electrode is observed to be ≈180 times greater than that of a bare TiO 2 electrode, mainly due to the enhanced electrical conductivity of the TiN phase produced through the nitridation process. Furthermore, the electrochemical capacitance can be enhanced linearly by constructing an electrode with multilayered shell films through a repeated transfer process (0.8 to 7.1 mF cm –2 , from one monolayer to 9 layers). Additionally, the high electrical conductivity of the shell film makes it an excellent scaffold for supporting other psuedocapacitive materials (e.g., MnO 2 ), producing composite electrodes with a specific capacitance of 743.9 F g –1 at a scan rate of 10 mV s –1 (based on the mass of MnO 2 ) and a good cyclic stability up to 1000 cycles.
Synthesis of L-Tryptophan from Indole and DL-Serine by Tryptophan Synthetase Entrapped in Fibres (1974)

Optimal culture conditions for microbial production of tryptophan synthetase were studied. It was found that on cultivation of Escherichia coli 476, a tryptophan auxotroph, in a medium containing 5g/liter glycerol as C source, supplemented with 1g/liter of acid treated peptone, cells with high tryptophan synthetase activity could be obtained. The enzyme was extracted from cells and 3-fold purified by heat treatment and ammo nium sulfate precipitation. The overall yield of the isolation procedure was 60%. The partially purified tryptophan synthetase was entrapped in cellulose triacetate fibres. Under storage conditions, in refrigerator, the entrapped enzyme was stable at least for 6 months. The activity of the entrapped enzyme was about 75% with respect to the free enzyme. Similar behaviour for the free and entrapped enzyme was observed as to the effect of temperature and pH on the enzymic activity. The operational stability of the entrapped tryptophan synthetase was very good (activity unchanged after 50 days) provided the accumulation of indole on the fibres was avoided.
Potassium Concentration after Ischaemia of Muscle (1943)

namely, by improvement of the ophthalmic services of the country, by education of the public on ophthalmic matters, and by further research into aetiology and therapeutics.
Silica‐Based Mesoporous Organic–Inorganic Hybrid Materials (2006)

Mesoporous organic-inorganic hybrid materials, a new class of materials characterized by large specific surface areas and pore sizes between 2 and 15 nm, have been obtained through the coupling of inorganic and organic components by template synthesis. The incorporation of functionalities can be achieved in three ways: by subsequent attachment of organic components onto a pure silica matrix (grafting), by simultaneous reaction of condensable inorganic silica species and silylated organic compounds (co-condensation, one-pot synthesis), and by the use of bissilylated organic precursors that lead to periodic mesoporous organosilicas (PMOs). This Review gives an overview of the preparation, properties, and potential applications of these materials in the areas of catalysis, sorption, chromatography, and the construction of systems for controlled release of active compounds, as well as molecular switches, with the main focus being on PMOs.
A Bibliometric Analysis of Research Journal ‘Asian Journal of Management, 2010–2017’ (2017)

In this study, an attempt has been made to investigate the ‘Asian Journal of Management, the period of 2010 to 2017’. This study analysis the year and volume-wise distribution of articles, year-wise references, and countrywise distribution of articles, forms of cited documents, authorship patterns of research contributions, single and multi authors of research contributions. The study has found that the contributions of articles to Asian Journal of Management were not only from in India but also from foreign countries. For the analysis of the study 08 volumes containing 28 issues have been taken up. It is found that 387 papers were published during the period of study. The maximum number of articles 87 (22.48%) articles was published in 2014. The average degree of collaboration is 0.563.
Discovery of genuine functional dependencies from relational data with missing values (2018)

Functional dependencies (FDs) play an important role in maintaining data quality. They can be used to enforce data consistency and to guide repairs over a database. In this work, we investigate the problem of missing values and its impact on FD discovery. When using existing FD discovery algorithms, some genuine FDs could not be detected precisely due to missing values or some non-genuine FDs can be discovered even though they are caused by missing values with a certain NULL semantics. We define a notion of genuineness and propose algorithms to compute the genuineness score of a discovered FD. This can be used to identify the genuine FDs among the set of all valid dependencies that hold on the data. We evaluate the quality of our method over various real-world and semi-synthetic datasets with extensive experiments. The results show that our method performs well for relatively large FD sets and is able to accurately capture genuine FDs.
Short communication: Examination of milk filters by real-time PCR as a herd-level indicator of the presence of Mycobacterium avium subspecies paratuberculosis in dairy herds (2012)

The aim of this study was to assess the suitability of real-time quantitative PCR (qPCR) for the detection of Mycobacterium avium ssp. paratuberculosis (MAP) in milk filters as a herd level indicator of paratuberculosis infection. Seventy-nine samples from textile or metal milk filters from 15 herds with defined MAP prevalence (infection status = noninfected, 0-5%, 5-10%, or >10% of animals with clinically confirmed paratuberculosis) were analyzed. The MAP DNA was isolated by a modified commercially available protocol for feces, and detection and quantification of the pathogen was performed by the IS900 qPCR. Mycobacterium avium ssp. paratuberculosis DNA was detected in 63 (79.7%) samples. Determination of MAP infection established by fecal and tissue culture was correctly confirmed by the analysis of milk filters on 11 of 12 infected farms; MAP was not detected in filters from 3 farms where paratuberculosis was never diagnosed. Statistical analysis of the data supports the evidence that milk filters can be used as a template for the direct detection of MAP on the herd level. The probability of successful MAP detection in milk filters in a herd with MAP-infected cows is at least 94.3%. Absolute numbers of MAP detected on the milk filter can be used for a rough estimation of paratuberculosis prevalence >10% in the herd. Analysis of milk filters for the presence of MAP can be a useful tool for the detection of paratuberculosis on the herd level before any individual control strategies.
Reliability of a quantitative interpretation of sputum cytology slides. (1990)

A sputum cytology method has been developed in which eight cytologic components associated with stimulation of the bronchial airways are quantified. The extent to which cytotechnologists could reliably and consistently utilize this system was measured. In an initial study (study A), four cytotechnologists had an overall intraobserver agreement of 90.2% and an interobserver agreement of 76.3%. There was an overall agreement with the laboratory standard of 85.6%. The most difficult components to consistently rate were mucous spirals and metaplastic, dysplastic and columnar cells. Study B was initiated after the implementation of a training program designed to better define both cytologic criteria and our system of quantitation. Two of the original cytotechnologists and a newly trained cytotechnologist participated in study B. The overall intraobserver agreement increased to 97.8% while the overall interobserver agreement increased to 97.5%. The overall agreement with the laboratory standard was 98.3%. These results indicate that a cytologic rating system employed for quantitative sputum cytology can be taught and applied reliably and consistently.
On the Origin of a Permanent Dipole Moment in Nanocrystals with a Cubic Crystal Lattice:  Effects of Truncation, Stabilizers, and Medium for CdS Tetrahedral Homologues (2006)

A large anomalous dipole moment has previously been reported for nanocrystals with a cubic crystal lattice. By considering truncations of a regular tetrahedral CdS nanocrystal, the hypothesis that shape asymmetry is responsible for the observed dipole moment was tested and verified. The location and degree of the truncations were systematically varied, and corresponding dipole moments were calculated by using a PM3 semiempirical quantum mechanical algorithm. The calculated dipole moment of 50-100 D is in good agreement with a variety of experimental data. This approach also affords simple evaluation of the potential effect of the media for aqueous dispersions of nanocrystals. The substitution of the truncated corner(s) by molecules of H2O typically results in a substantial increase of the dipole moment, and often, in the reversal of its direction. The molecular modeling approach presented here is suitable for detailed theoretical studies of the dipole moments of II-VI and other nanoparticles and interparticle interactions in fluids. The data obtained from these calculations can be the starting point for modeling of agglomeration and self-organization behavior of large nanoparticle ensembles.
A Synthesis of Triptoquinones D, E, and F from Podocarpic Acid (1998)

The First total synthesis of enantiopure triptoquinone F (6) starting from podocarpic acid (10) is reported, as well as formal syntheses of enantiopure triptoquinones D (4) and E (5). An acid-promoted Fries rearrangement of a benzannulated lactone (14) has been used as a direct, moderately high yielding route for introduction of C11 functionality. Treatment of methyl 12-methoxypodocarpa-8,11,13-trien-19-oate (11) with t-butylhydroperoxide and a catalytic amount of ruthenium(III) chloride gives a mixture (1 : 1) of diastereomeric t-butylcyclohexadienones (26) and (28).
CONTACT DERMATITIS FROM PENICILLIN (1944)

In November 1943 a penicillin section was established at the Gardiner General Hospital. The medical officer in charge, who undertook to prepare the various solutions as well as to administer the drug to patients, noted shortly thereafter that he had a mild marginal blepharitis and conjunctivitis with some blurring of vision on reading. Glasses were prescribed for the condition, but the blepharitis persisted and soon there developed a dermatitis which began on the bridge of the nose and spread to involve adjacent areas of the forehead and the central oval of the face. The eruption had the characteristics of a relatively acute dermatitis due to contact with an irritant, and its source was thought to be in the plastic frames of the newly acquired glasses. These glasses were discarded, but the dermatitis became progressively worse despite topical treatment with bland preparations, and in the course of a few weeks similar
A piezoelectric method of measuring the vertical contact stress beneath the human foot (1982)

A new piezoelectric device has been developed for measuring the vertical contact stresses generated between the plantar surface of the foot and the insole of a shoe during walking and running. This paper describes the device and its associated data processing and display system and presents an example of the sort of detailed information that can be obtained from it.
TM-pass electro-optic APC-CPW polymeric modulators with poling-induced waveguides and self-aligned electrodes (2004)

In this paper, TM-pass polymer Mach-Zehnder modulators with self-aligned electrodes were fabricated using a poling-induced writing method in APC-CPW1. A single-arm, 3-cm long electrode device shows a V/sub /spl pi// of 3.5 V. Measured driving voltages at 1.55 /spl mu/m show promising values, which could be further reduced by a push-pull electrode configuration.
MBAL: A Mobile Beacon-Assisted Localization Scheme for Wireless Sensor Networks (2007)

Localization is one of the critical issues on wireless sensor networks. Localization schemes are classified into range-based and range-free according to the method of whether to use range information. In this paper, we propose a novel range-based localization scheme which involves a movement strategy of mobile beacon, called mobile beacon-assisted localization (MBAL). Contrary to many research activities which have been carried out to design localization schemes using mobile beacons only based on random movement method, we consider totally a new scheme providing movement path selection with a low computational complexity. A new range check technique is also adopted into the MBAL as a useful solution to the position-ambiguity problem of bilateration in order to improve the performance of the proposed localization scheme. Simulation results verify that the MBAL impressively achieves energy efficiency because of its mobile beacon based approach using the proposed movement strategy and range check technique.
EAP Key Management Framework (2003)

The rate of gastric emptying of different liquid solutions was measured in 80 voluntary normal young male subjects (mean age 19.9 +/- 1.6 years) by direct real-time ultrasonic imaging. Multiple US scans were repeated at regular intervals (15-30 minutes) until complete gastric emptying was established, after ingestion of 500 cc of 8 different liquid test meals: isotonic saline, 50% glucose, 5% glucose, 40 g of proteins, 20 g of protein, 40 g of fat, 20 g of fat and mixed (carbohydrates, proteins and fat). Eight groups of ten subjects were studied, each one with a different test meal. Three types of gastric emptying were identified: slow (177 +/- 12 minutes) in subjects receiving 50% glucose, 40 and 20 grs of proteins and mixed test meals; intermediate (83 +/- 9 minutes) with 5% glucose, 40 and 20 g of fat; rapid (40 +/- 6 minutes) with isotonic saline. The mixed diet had the slowest emptying time (210 +/- 6 min). Our results are in accordance with published data regarding gastric motor physiology and demonstrates the usefulness of ultrasound in the study of gastric emptying of fluids.
Boundary Control of a Coupled Nonlinear Flexible Marine Riser (2009)

In this paper, boundary control for a coupled nonlinear flexible marine riser with two actuators in transverse and longitudinal directions is developed to reduce the riser's vibrations. The dynamic behavior of the flexible riser is represented by a distributed parameter system with partial differential equations (PDEs) and the control is applied at the top boundary of the riser based on Lyapunov's direct method to regulate the riser's vibrations. With the proposed boundary control, uniform boundedness under ocean current disturbance, and exponential stability under free vibration condition can be achieved. The proposed control is independent of system parameters, which ensures the robustness of the system to variations in parameters. Numerical simulations for demonstrating the effectiveness of the proposed control are presented.