gebhart/patrepeval huggingface dataset:
Autosomal Dominant Growth Hormone (GH) Deficiency Type II: The Del32–71-GH Deletion Mutant Suppresses Secretion of Wild-Type GH<sup>1</sup> (2000)

Familial isolated GH deficiency type II is an autosomal dominant form of short stature, associated in some families with mutations that result in missplicing to produce del32-71-GH, a protein that cannot fold normally. The mechanism by which this mutant suppresses the secretion of wild-type GH encoded by the normal allele is not known. Coexpression of del32-71-GH with wild-type human GH in transient transfections of the neuroendocrine cell lines GH4C1 and AtT20 suppressed accumulation of wild-type GH. The suppression of wild-type GH accumulation by del32-71-GH was a posttranslational effect on wild-type GH caused by decreased stability, rather than decreased synthesis, of wild-type GH. Coexpression of del32-71-GH with human PRL did not suppress accumulation of PRL, indicating that there was not a general suppression of secretory pathway function. Accumulation of del32-71-GH protein was not necessary for the suppression of wild-type GH, because del32-71-GH did not accumulate in the neuroendocrine cell lines in which suppression of accumulation of wild-type GH was observed. Del32-71-GH did accumulate in transfected COS and CHO cells, but did not suppress the accumulation of wild-type GH in these cells. These studies suggest that del32-71-GH may cause GH deficiency in somatotropes of heterozygotes expressing both wild-type and del32-71-GH by decreasing the intracellular stability of wild-type GH.
Distribution of Isomorphous Salts between Aqueous and Solid Phases in Fractional Crystallization. Nickel Ammonium Sulfate-Magnesium Ammonium Sulfate-Water and Barium Nitrate-Lead Nitrate-Water Systems (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDistribution of Isomorphous Salts between Aqueous and Solid Phases in Fractional Crystallization. Nickel Ammonium Sulfate-Magnesium Ammonium Sulfate-Water and Barium Nitrate-Lead Nitrate-Water SystemsA. S. Ananda Murthy and D. S. MahadevappaCite this: Ind. Eng. Chem. Process Des. Dev. 1970, 9, 2, 260–263Publication Date (Print):April 1, 1970Publication History Published online1 May 2002Published inissue 1 April 1970https://doi.org/10.1021/i260034a016RIGHTS & PERMISSIONSArticle Views42Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (387 KB) Get e-Alerts
“O My Language, Help me to Learn / So That I May Embrace the Universe”: Transnational Feminist Communities in the Work of Palestinian Women Writers (2024)

In the title quote, Mahmoud Darwish (1941-2008) expresses his desire for a space that preserves Palestinian identity within a wider culture. Rather than leaving ties to Palestine behind, Darwish, like writers included in this article – Susan Abulhawa, Hala Alyan, Randa Jarrar, and Naomi Shihab Nye, to name a few – puts his homeland within a framework of diasporic space. Similarly, Rana Barakat views exile as both an individual “shipwreck” and a communal journey, a stance that reflects intersectional feminist values. Negotiating “the isolation of the individual within our shared collective condition,” Barakat offers what Anna Ball terms a “transnational feminist approach”. She joins a larger body of post 1948 writers who construct what the “poet of witness” Caroline Forché calls “assembled communities”, groups of friends who, she says, are “varied in the universe” but come together via various kinds of communication in order to discuss common issues. This article seeks to explore a variety of transformative dialogues which transcend difference by standing together for justice, equality, and peace. How might feminist writers and activists negotiate a balance between connecting to their homeland but also recognize the potential that arises from the transnationalism of Avtar Brah’s concept of “diasporic space?” As a place marked by hybridity, where tradition is continually transformed, this theoretical concept addresses the confluence of migrating populations, capital, commodities and culture. This article also builds on Steven Salaita’s Inter/Nationalism: Decolonizing Native America and Palestine (2016), a work that explores how such dialogues across borders offer a viable means of resistance. As Cynthia Franklin, editor of Biography’s special issue “Life in Occupied Palestine” (2014), notes, while sumoud (steadfastness) is a Palestinian tradition, it gains strength when Palestinians ally with social groups who are interconnected via various means of oppression.
Influence of reconstruction iterations on 18F-FDG PET/CT standardized uptake values. (2005)

The OSEM algorithm converges sooner for avgSUV than for maxSUV. The likely reason is that avgSUV depends on low-frequency features that are recovered with fewer iterations. The differences in maxSUV were likely due to noise, which increased with the number of iterative updates, and to increased resolution and recovery of high-frequency features (i.e., tumor heterogeneity) with a larger number of iterations. Factors that determine the quantitative accuracy of iterative reconstruction may have played an additional role. Given the continued change in maxSUV with iterations, great care must be taken in selecting the number of iterative updates when using it to assess tumors and their response to chemotherapy and radiation therapy. Because 2-5 iterations with 8-28 subsets are being used in clinical settings, these data are pertinent when comparing the SUVs of a tumor before and after therapy.
ChemInform Abstract: High Pressure Synthesis and Crystal Structure of Al3Au8. (1989)

Abstract The title intermetallic phase, synthesized by melting the elements at 2 kbar in a modified Belt‐type apparatus, crystallizes in the rhombohedral system, space group R3c, Z=12.
Ten Tips for Safer Suctioning (1995)

1Research coordinator on the Medical Respiratory Intensive Care Unit at the Medical College of Virginia Hospitals in Richmond 2Assistant professor at Virginia Commonwealth University School of Nursing, also in Richmond
Nucleocytoplasmic shuttling of phospholipase C‐δ<sub>1</sub>: A link to Ca<sup>2+</sup> (2005)

Phosphoinositides (PIs) and proteins involved in the PI signaling pathway are distributed in the nucleus as well as at the plasma membrane and in the cytoplasm, although their nuclear localization mechanisms have not been clarified in detail. Generally, proteins that shuttle between the cytoplasm and nucleus contain nuclear localization signal (NLS) and nuclear export signal (NES) sequences for nuclear import and export, respectively. They bind to specific carrier proteins of the importin/exportin family and are transported to and from the nucleus. Thus there is a steady state shuttling of the cargo molecules to and from the nucleus, and the shift in equilibrium determines their nuclear or cytoplasmic localization. Our previous studies have shown that phospholipase C (PLC)-delta1, regarded as having cytoplasmic- or plasma membrane-bound localization, accumulates in the nucleus when its NES sequence is disrupted. In addition, a cluster of positively charged residues on the surface of the catalytic barrel is important for nuclear import. In quiescent cells, the shuttling equilibrium seems to be shifted to the nuclear export of PLCdelta1. In this review, recent findings regarding the molecular machineries and mechanisms of the nucleocytoplasmic shuttling of PLCdelta1 will be discussed. It is important to know when and how they are regulated. A shift in the equilibrium in a certain stage of the cell cycle or by external stimuli is possible and resulting changes in the intra-nuclear environments (or architectures) may alter proliferation and differentiation patterns. Evidences support the idea that an increase in the levels of intracellular Ca2+ shifts the equilibrium to the nuclear import of PLCdelta1. A myriad of external stimuli have also been reported to change the nuclear PI metabolism following accelerated accumulation in the nucleus of other phospholipases such as phospholipase A2 and phospholipase D in addition to PLC isoforms such as PLCbeta1 and PLCgamma1. The consequence of the nuclear accumulation of PLC is also discussed.
Development of Radiation Hard Fiber for IFOGs (2006)

This paper will report on the development of fiber for IFOG sense coils and fiber light sources deployed in radiation environments. Radiation hard polarization-maintaining fibers have been demonstrated.
Characterization of Cystic Lesions by Spectral Mammography (2016)

Discriminating cystic from solid lesions with spectral mammography demonstrates promising results with the potential to reduce mammographic recalls. It is estimated that for each missed cancer at least 625 cystic lesions would have been correctly identified and hence would not have been needed to be recalled. Our results justify undertaking a larger reader study to refine the algorithm and determine clinically relevant thresholds to allow safe classification of cystic lesions by spectral mammography.
Experimental Performance of a Trochoidal Propeller with High-Aspect-Ratio Blades (1989)

Open-water experiments were done on a model of a cycloidal-type propeller with a trochoidal blade motion. This propeller had three blades with an aspect ratio of 10. These experiments included the measurement of thrust and torque of the propeller over a range of advance ratios. Tests were done for forward and reverse operation, and at zero speed (the bollard pull condition). Results from these tests are presented and compared with: a multiple stream-tube theoretical prediction of the performance of the propeller; and a prediction of the performance of a single blade of the propeller, oscillating in heave and pitch, using unsteady small-amplitude hydrofoil theory with corrections for finite amplitude motion, finite span, and frictional drag. At present, neither of these theories gives a completely accurate prediction of propeller performance over the whole range of advance ratios, but a combination of these approaches, with an allowance for dynamic stall of the blades, should lead to a reliable simple theory for overall performance prediction. Application of a propeller of this type to a small ship is discussed. The aim of the design is to produce a lightly loaded propeller with a high efficiency of propulsion.
The Relationship between Wide Reading and Listening Comprehension of Written Language (1995)

This study was the first to examine the relationship between wide reading and listening comprehension in the first language. It answered two questions concerning this relationship. First, higher levels of wide reading were associated with stronger listening comprehension ability. Second, there was indirect evidence to suggest that wide readers may be increasing their listening comprehension ability. One hundred and twenty fourth graders were measured on general language ability, estimated amount of wide reading, and reading-related language ability. A hierarchical regression logic was used to isolate the relationship between wide reading and reading-related language development. Further research that more directly investigates the relationship between wide reading and reading-related language development is called for.
Studies on the Xylanase from Streptomyces (1965)

Xylanase from Streptomyces xylophagus nov. sp. has been purified by ammonium sulfate fractionation and chromatography on DEAE-cellulose column. The purification of the enzyme was 276-fold with a yield of 18.6% on the basis of the activity per weight of total nitrogen. The purified enzyme was homogeneous on moving-boundary electrophoresis. Optimum pH and temperature for the enzyme activity were 6.2 and 55_??_60°C, respectively. The enzyme was stable up to 40°C and in the range of pH from 5.3 to 7.3, but inactivated at higher than 50°C and at extreme pH values of 2.4 and 9.4. Hydrolyzed products of xylan by the enzyme were xylose and xylobiose.
Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of <i>Crithidia fasciculata</i> trypanothione reductase (1995)

The enzyme trypanothione reductase (TR), together with its substrate, the glutathione-spermidine conjugate trypanothione, plays an essential role in protecting parasitic trypanosomatids against oxidative stress and is a target for drug design. Here we show that a naturally occurring spermine derivative, the antihypertensive agent kukoamine A [N1N12-bis(dihydrocaffeoyl)-spermine] inhibits TR as a mixed inhibitor (Ki = 1.8 microM, Kii = 13 microM). Kukoamine shows no significant inhibition of human glutathione reductase (Ki > 10 mM) and thus provides a novel selective drug lead. The corresponding N1N8-bis(dihydrocaffeoyl)spermidine derivative was synthesized and acted as a purely competitive inhibitor with Ki = 7.5 microM. A series of mono- and di-acylated spermines and spermidines were synthesized to gain an insight into the effect of polyamine chain length, the nature and position of the acyl substituent and the importance of conformational mobility. These compounds inhibited TR with Ki values ranging from 11 to 607 microM.
Arc Faults in Photovoltaic Systems (2010)

In photovoltaic systems a large amount of electrical connectors has been used in the combination of serial and parallel structures of the modules. Due to the high DC voltages and the aging of the systems, long-lasting arc faults can occur which may cause serious fires. As an initial step to develop sensor-devices for detecting arc faults in photovoltaic systems, a test set-up consisting of several modules, a solar inverter, and a unit for creating artificial arc faults was installed. The analysis of the measured signals in time and frequency domain showed the following: Parallel arcing involves significant changes in the current at the primary side of the converter and is therefore easily detectable. Series arc faults, however, can usually not be detected by a low frequency analysis of current and voltage signals due to the specific characteristic curve of the photovoltaic modules, the control-concept of the converter for maximum power tracking, and possibly changing solar irradiance. Sensors and methods considering the higher spectral components of the arc effects are necessary.
El laberinto de los sueños (1998)

It has been suggested that sleep may have a positive effect on morning motor symptoms in Parkinson's disease (PD). We examined this possibility and also looked at common sleep disorders in PD. Seventy-eight PD patients and 43 normal elderly subjects answered a questionnaire. Of the PD patients, 43.6% reported improved motor symptoms in the morning, 37.2% worse, and 19.2% unchanged compared to the rest of the day. No difference was found between morning-better and -worse groups with respect to age, duration or stage of PD; antiparkinsonian medications utilized, and predominant motor symptoms. However, the morning-same group had a shorter duration of PD and less severe disease and required fewer dopaminergic medications. Sleep disorders were seen with equal frequency in the morning-better and -worse groups. Our results suggest that sleep does not have a direct effect on morning motor function. Alterations in morning motor symptomatology probably represent a manifestation of motor fluctuations. Sleep fragmentation and spontaneous daytime dozing occurred much more frequently in PD patients than controls. In addition, nocturnal vocalizations and daytime hallucinations occurred only in the PD group.
Rationales for holonic manufacturing systems in chemical process industries (2002)

Examines the rationale for applying so-called holonic manufacturing principles as a technological solution to a number of growing business concerns of chemical process industries. A requirements deployment process coupled with a vision for a "holonic process plant" is used to illustrate how a holonic approach might reform the conventional engineering and control design methods in chemical processes.
Compact Monopole Antenna With Band-Notched Characteristic for UWB Applications (2010)

A compact planar monopole antenna with standard band-notched characteristic suitable for ultrawideband (UWB) applications is presented. This microstrip-fed antenna, consisting of a square slot patch with a vertical coupling strip, only occupies a small size of 15 (L) × 15 (W) × 1.6 (H) mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> . By properly designing the strip placed at the center of the patch, good frequency rejection performance of the antenna with a wide operating band from 3.05 to 11.15 GHz can be obtained. Compared to other designs, the antenna has a quite simple structure to make the band-notched property to reduce the effect caused by the frequency interference. Furthermore, fairly good omnidirectional radiation patterns and transmission responses both indicate that the proposed antenna is well suited to be integrated within various portable devices for UWB operation.
Respiratory mechanics in mechanically ventilated patients with respiratory failure (1985)

In 11 mechanically ventilated patients, respiratory mechanics were measured 1) during constant flow inflation and 2) following end-inflation airway occlusion, as proposed in model analysis (J. Appl. Physiol. 58: 1840-1848, 1985. During the latter part of inflation, the relationship between driving pressure and lung volume change was linear, allowing determination of static respiratory elastance (Ers) and resistance (RT). The latter represents in each patient the maximum resistance value that can obtain with the prevailing time constant inhomogeneity. Following occlusion, Ers and RT were also obtained along with RT (min) which represents a minimum, i.e., resistance value that would obtain in the absence of time constant inhomogeneity. A discrepancy between inflation and occlusion Ers and RT was found only in the three patients without positive end-expiratory pressure, and could be attributed to recruitment of lung units during inflation. In all instances Ers and RT were higher than normal. RT(min) was lower in all patients than the corresponding values of RT, indicating that resistance was frequency dependent due to time constant inequalities. Changes in inflation rate did not affect Ers, while RT increased with increasing flow.
Thermally stable multilared organic electroluminescent devices using novel starburst molecules, 4,4′,4″‐Tri(<i>N</i>‐carbazolyl)triphenylamine (TCTA) and 4,4′,4″‐Tris(3‐methylphenylphenylamino)triphenylamine (<i>m</i>‐MTDATA), as hole‐transport materials (1994)

Organic electroluminescent devices with improced thermal stability and good performance characteristics are reported. The hole‐transport material is a novel π‐electron “starburst” molecule, TCTA (see Figure), whose glass‐transition temperature is increased by the introduction of a structurally rigid moiety. magnified image
Defining Dignity and Its Place in Human Rights (2014)

The concept of dignity is widely used in society, particularly in reference to human rights law and bioethics. Several conceptions of dignity are identified, falling broadly within two categories: full inherent dignity (FID) and non-inherent dignity (NID). FID is a quality belonging equally to every being with full moral status, including all members of the human natural kind; it is permanent, unconditional, indivisible and inviolable. Those beings with FID ought to be treated deferentially by others by virtue of their belonging to a noble caste. FID grounds fundamental human rights, such as the rights to freedom and equality.The concept of dignity forms a network of interconnected ideas related to worth and value particularly within legal and ethical discourse; it is a rich and meaningful concept, irreducible to one or two quasi-legal principles. Fundamentally, dignity matters because it forms the foundation of civilized society; without it, serious abuse of people is more likely to occur.
Expression of the Haemophilus influenzae transferrin receptor is repressible by hemin but not elemental iron alone (1993)

The absolute requirement for elemental iron and the porphyrin nucleus for growth of Haemophilus influenzae led us to investigate the role of iron and hemin in regulation of expression of the H. influenzae transferrin receptor. H. influenzae type b strain H1689 was grown in brain heart infusion broth supplemented with beta-NAD and either 10 or 0.1 microgram of hemin ml-1. Transferrin-binding ability was determined with a dot blot assay using human transferrin-horseradish peroxidase conjugate. Cells grown in media with 0.1 microgram of hemin ml-1 bound transferrin, but organisms grown in media with 10 micrograms ml-1 did not. In hemin-restricted media, transferrin binding occurred despite addition of up to 10 mM ferric nitrate, ferric citrate, or ferric PPi, whereas addition of 10 micrograms of hemoglobin ml-1 repressed expression. The breadth of species distribution of this mode of regulation was determined with strains previously characterized by multilocus enzyme electrophoresis. When grown in hemin-restricted media, 24 of 28 type b strains and 52 of 57 serologically nontypeable strains exhibited transferrin binding, although none did so in hemin- and iron-sufficient media. Strain H1689 and serologically nontypeable strain HI1423 grown in heat-inactivated pooled normal human serum, human cerebrospinal fluid, or human breast milk exhibited transferrin binding. Growth in these fluids with 10 micrograms of added hemin ml-1 abolished transferrin binding, whereas addition of 10 mM ferric nitrate did not. These data suggest that the transferrin receptor of H. influenzae is regulated by levels of hemin but not elemental iron alone and that this property is widely distributed among several major cloned families in the species.