gebhart/patrepeval huggingface dataset:
Microencapsulated Pancreatic Islet Allografts Into Nonimmunosuppressed Patients With Type 1 Diabetes (2006)

Time-related decline of human islet allograft (TX) function in generally immunosuppressed type 1 diabetic patients (1–5) has led us, after years of preclinical study (6), to initiate a phase 1 pilot clinical trial of microencapsulated TX into 10 nonimmunosuppressed patients with type 1 diabetes, under permission and surveillance by the Italian Ministry of Health (file no. 19382, PRE 805, 5 September 2003).

### Human islet procurement

Human islets were isolated from single-donor pancreases according to the Edmonton protocol (1). Only preparations complying with standard quality control criteria (1) were considered for TX. The islets were cultured for 24 h in HAM F12 (Celbio, Milano, Italy), supplemented with antibiotics and 1.25% human albumin (Kedrion Spa, Milano, Italy) at 37°C in 95% air/CO2.

### Microencapsulation

The islets were washed and thoroughly mixed with 1.6% endotoxin- and pyrogen-free sodium alginate (Stern Italia, Milan, Italy) that had been highly purified according to U.S. Pharmacopeia. Upon extrusion …
An Arterially Perfused Decerebrate Preparation of Suncus Murinus (House Musk Shrew) for the Study of Emesis and Swallowing (2002)

Arterially perfused, decerebrate preparations of the insectivore, Suncus murinus were made to determine whether the emetic reflex could be activated in such a preparation using a range of stimuli shown to be emetic in conscious or anaesthetised Suncus. Efferent phrenic and vagus nerve activities and electromyograms (EMGs) from the temporalis, abdominal oesophagus and trapezius muscles were recorded, as well as longitudinal shortening of the oesophagus and dorso-ventral movements of the thorax. The preparations swallowed spontaneously every 0.6 to 6.5 min. The duration of a swallow was 3.1 +/- 0.3 s (recorded as the time taken for the oesophagus to shorten and recover to its resting position) and the oesophagus shortened by 3.5 +/- 0.4 mm during a swallow. The emetic reflex was activated by electrical stimulation (30 Hz, 10-20 V, 0.2 ms pulse width, for 30 s) of abdominal vagal afferents (latency < 30 s) or by arterial perfusion with either 40 nM of the capsaicin analogue resiniferatoxin (latency 1.7 +/- 0.6 min), 6 microM nicotine (latency 1.6 +/- 0.1 min) or 1 microM of the phosphodiesterase IV inhibitor CP-80,633 (latency 8.9 +/- 3.9 min). These emetic stimuli produced somatic and visceral movements in Suncus preparations indicative of activation of the emetic reflex. There were pronounced contractions of the thorax that occurred simultaneously with oesophageal shortening and mouth opening, separated by thorax expansion and a burst of phrenic nerve activity. During emetic-like episodes, oesophageal shortenings were only 0.84 +/- 0.1 s in duration, faster than the duration of shortening observed during swallowing (cf. swallowing, 3.1 +/- 0.3 s; P < 0.0001). The shortening of the oesophagus during emetic-like episodes was 6.2 +/- 0.4 mm, which was greater than the shortening seen during swallowing (cf. swallowing, 3.5 +/- 0.4 mm; P < 0.0001). We conclude that the emetic reflex can be activated in our Suncus preparations and that this non-sentient small adult animal model can now be used to study the neurophysiology and pharmacology of swallowing and emesis.
Beyond Redundancy: How Geographic Redundancy Can Improve Service Availability and Reliability of Computer-Based Systems (2011)

"While geographic redundancy can obviously be a huge benefit for disaster recovery, it is far less obvious what benefit is feasible and likely for more typical non-catastrophic hardware, software, and human failures. Georedundancy and Service Availability provides both a theoretical and practical treatment of the feasible and likely benefits of geographic redundancy for both service availability and service reliability. The text provides network/system planners, IS/IT operations folks, system architects, system engineers, developers, testers, and other industry practitioners with a general discussion about the capital expense/operating expense tradeoff that frames system redundancy and georedundancy"--
Identification of mRNAs that continue to associate with polysomes during hypoxia (2007)

Tumors must adapt to the hypoxic environment in order to grow beyond a benign microscopic mass. In addition to transcriptional activation mediated by HIF-1alpha, hypoxia has also been reported to inhibit translation. The degree of translational inhibition is dependent on the duration as well as the severity of the hypoxic insult. Anoxia (<0.02% O(2)) seems to have a more rapid and dramatic effect on translation as compared to hypoxia. We show here that prolonged hypoxia dramatically and reversibly inhibits translation in PC-3 cells. We also found that mTOR is inactivated and eIF-2alpha is phosphorylated during hypoxic treatment but only the eIF-2alpha phosphorylation correlates with the translational repression. We further used polysome analysis and microarray technology to analyze the impact of this translational repression on gene expression. We found that 33 mRNAs were refractory to this translational repression and that there was no correlation between mRNA induction and the ability to recruit ribosomes during hypoxia. We also found that ribosomal protein encoding mRNAs are more sensitive to this translational repression as compared to the majority of mRNAs. Although other reports have analyzed the effect of translation inhibition on gene expression under anoxic conditions, we believe that this is the first report in hypoxic cells. Our results show that the translational repression that occurs during hypoxia does impact gene expression in the highly transformed prostate cancer cell line, PC-3.
Incidence and Risk Factors for Ventilator-Associated Pneumonia in 4 Multidisciplinary Intensive Care Units in Athens, Greece (2003)

VAP is a common infection and certain interventions might affect the incidence of VAP. ICU clinicians should be aware of the risk factors for VAP, which could prove useful in identifying patients at high risk for VAP and modifying patient care to minimize the risk of VAP, such as avoiding unnecessary bronchoscopy or modulating enteral feeding.
Visualization tools for Free Flight air-traffic management (2000)

Free Flight lets pilots modify their routes in real time. It requires new conflict detection, resolution, and visualization decision support tools. We describe a testbed for building and evaluating such tools.
Soluble Tac peptide is present in the urine of normal individuals and at elevated levels in patients with adult T cell leukaemia (ATL). (1988)

The T lymphocyte-derived lymphokine interleukin 2 and the cell-associated receptor for this molecule play major roles in the activation and regulation of the human immune response. An enzyme-linked immunosorbent assay has been developed to measure quantitatively a soluble form of one component of the human interleukin 2 receptor, namely the Tac peptide. In the present studies, soluble Tac peptide was measured in the urine of normal individuals (mean = 92 U/ml), a level not significantly different (0.01 less than P less than 0.05) from the corresponding serum concentrations (mean = 175). The urinary Tac peptide had a molecular weight of 40-45 kD by sodium dodecyl sulphate-polyacrylamide gel electrophoresis analysis and specifically bound interleukin 2. Elevated levels of urinary Tac peptide were found in four patients with adult T cell leukaemia who also had elevated serum levels of Tac peptide. Thus, urine may represent a valuable source of lymphokine-binding proteins that may serve as important markers of immunological activation.
Human bone marrow mesenchymal stem cell transplantation attenuates axonal injury in stroke rats (2014)

Previous studies have shown that transplantation of human bone marrow mesenchymal stem cells promotes neural functional recovery after stroke, but the neurorestorative mechanisms remain largely unknown. We hypothesized that functional recovery of myelinated axons may be one of underlying mechanisms. In this study, an ischemia/reperfusion rat model was established using the middle cerebral artery occlusion method. Rats were used to test the hypothesis that intravenous transplantation of human bone marrow mesenchymal stem cells through the femoral vein could exert neuroprotective effects against cerebral ischemia via a mechanism associated with the ability to attenuate axonal injury. The results of behavioral tests, infarction volume analysis and immunohistochemistry showed that cerebral ischemia caused severe damage to the myelin sheath and axons. After rats were intravenously transplanted with human bone marrow mesenchymal stem cells, the levels of axon and myelin sheath-related proteins, including microtubule-associated protein 2, myelin basic protein, and growth-associated protein 43, were elevated, infarct volume was decreased and neural function was improved in cerebral ischemic rats. These findings suggest that intravenously transplanted human bone marrow mesenchymal stem cells promote neural function. Possible mechanisms underlying these beneficial effects include resistance to demyelination after cerebral ischemia, prevention of axonal degeneration, and promotion of axonal regeneration.
A new approach: Low cost masking material and efficient copper metallization for higher efficiency silicon solar cells (2015)

A new approach based on the development of a new low-cost masking material and a new technique for performing fast wet processes (i.e. chemical etching and electroplating processes) are presented, back side silver removal is proposed allowing in combination with a multi-bus bar module assembly technique to boost standard silicon solar cells towards higher efficiencies at low cost. The new masking material based on a low-cost wax is able to withstand wet hot chemical treatment up to 100 °C. The developed wax composition that costs 10 times less than photoresist can be taken into consideration as an industrial masking process for solar cell for the front copper metallization process. However, the industrial applicability of the copper plating processes foresees several issues concerning the cell throughput for the plating technique at industrial level, which is directly connected to the plating speed. In this work, it is shown how using the new concept of coalescent dynamic liquid drop/meniscus is possible to plate 35 μm thick copper fingers on wax masked solar cell with a deposition speed as high as 1 μm/s. Combining the proposed technique with the back side selective plating, a silver-free silicon solar cell fabrication process is developed allowing to reach efficiencies higher than 18 % for monocrystalline silicon solar cell.
Polynomial cancellation coding and finite differences (2000)

We give a mathematical context for polynomial cancellation coding, proposed previously to reduce intercarrier interference in orthogonal frequency division multiplexing (OFDM). In particular, we analyze polynomial cancellation coding (PCC) in terms of finite differences.
Automated Disk Drive Characterization (CMU-CS-99-176) (2018)

DIXtrac is a program that automatically characterizes the performance of modern disk drives. This report describes and validates DIXtrac's algorithms, which extract accurate values for over 100 performance-critical parameters in 2 to 6 minutes without human intervention or special hardware support. The extracted data include detailed layout and geometry information, mechanical timings, cache management policies, and command processing overheads. DIXtrac is validated by configuring a detailed disk simulator with its extracted parameters; in most cases, the resulting accuracies match those of the most accurate disk simulators reported in the literature. To date, DIXtrac has been successfully used on over 20 disk drives, including eight different models from four different manufacturers.
A reference genome for pea provides insight into legume genome evolution (2019)

We report the first annotated chromosome-level reference genome assembly for pea, Gregor Mendel's original genetic model. Phylogenetics and paleogenomics show genomic rearrangements across legumes and suggest a major role for repetitive elements in pea genome evolution. Compared to other sequenced Leguminosae genomes, the pea genome shows intense gene dynamics, most likely associated with genome size expansion when the Fabeae diverged from its sister tribes. During Pisum evolution, translocation and transposition differentially occurred across lineages. This reference sequence will accelerate our understanding of the molecular basis of agronomically important traits and support crop improvement.
Failure prediction using machine learning and time series in optical network (2017)

In this paper, we propose a performance monitoring and failure prediction method in optical networks based on machine learning. The primary algorithms of this method are the support vector machine (SVM) and double exponential smoothing (DES). With a focus on risk-aware models in optical networks, the proposed protection plan primarily investigates how to predict the risk of an equipment failure. To the best of our knowledge, this important problem has not yet been fully considered. Experimental results showed that the average prediction accuracy of our method was 95% when predicting the optical equipment failure state. This finding means that our method can forecast an equipment failure risk with high accuracy. Therefore, our proposed DES-SVM method can effectively improve traditional risk-aware models to protect services from possible failures and enhance the optical network stability.
ChemInform Abstract: STUDY OF BENZOFURAN. LX. ORIENTATION OF THE ALKALINE DEGRADATION OF 3‐AROYL‐2‐ETHYLBENZOFURANS DEPENDING ON THE AROYL GROUP SUBSTITUENT (1978)

Abstract 3‐Aroyl‐2‐ethylbenzofurane (I) liefern mit Alkali über die Anionen (II) je nach dem Verlauf der Eliminierung die 2‐Ethyl‐ (III) bzw. die 2‐Aryl‐benzofurane (IV).
Microsoft SharePoint 2010 (2010)

This book provides a fresh take on Microsoft’s premier collaboration solution. A critical resource if you’re developing on the SharePoint platform, this book features a complete focus on the new featu
Preparation of CoCr thin films on polymer substrates by ion beam sputtering (1987)

CoCr thin films have been deposited on polymer substrates by ion beam sputtering. The magnetic and crystallographic properties have been investigated in the films deposited under a range of preparation parameters such as ion acceleration voltage, substrate temperature, and substrate bias voltage. The typical half-value width of the x-ray rocking curve Δθ50 is 10°. Transmission electron microscopy revealed that the films on the polyimide substrate under high substrate voltage showed columnar structure, but that without the voltage there were coarse grains and no clear columnar structure. The relations among coercive force (Hc⊥), saturation magnetization (Ms⊥), Δθ50, and Co content are discussed.
ChemInform Abstract: A Synthesis of Fused Pyrimidine Mono‐N‐oxides. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electron-impact excitation of the sodium atom (1981)

Absolute electron-impact optical-excitation functions of 26 transitions of the sharp, principal, diffuse, fundamental, and $\mathrm{nP}\ensuremath{-}4S$ series of sodium have been measured in the impact-energy range 0-150 eV. The determination of the target-atom number density was made by measuring the attenuation of sodium resonance radiation from a fluorescence cell upon passage through the collision chamber. Direct-excitation cross sections of 14 states ($4S$, $5S$, $6S$, $7S$, $3P$, $4P$, $5P$, $6P$, $3D$, $4D$, $5D$, $6D$, $6F$, and $7F$) have been determined from the measured optical-excitation cross sections with the aid of radiative-transition probabilities taken from the literature. These direct-cross-section results are compared with theoretical calculations based upon the Born approximation and the multistate-close-coupling approximation. Measurements were also made of the polarization of several sharp, principal, and diffuse series-resolved doublets, and from these results the direct-excitation functions of the separate orbital magnetic sublevels of the $3P$ state have been determined.
Timing-driven placement for hierarchical programmable logic devices (2001)

In this paper we discuss new techniques for timing-driven placement and adaptive delay computation for hierarchical PLD architectures.
A dual watermark-fingerprint system (2004)

This article proposes a multimedia content protection system in which all copies of a protected object are identically watermarked, but each user has a distinct secret detection key that differs from the secret embedding key. An attacker with access to one detection key can fool the corresponding watermark detector but not other watermark detectors. Surprisingly, analogous to a criminal action, during this attack the attacker necessarily inserts his or her fingerprint into the modified content. Even a collusion clique of relatively large size cannot entirely remove the secret marks from the protected content by colluding their detection keys. More importantly, if the clique is not large enough, traces of the detection keys of all colluders can be detected with relatively high accuracy in the attacked clip. Our proposed watermark-fingerprint system achieves a minimum collusion size K that grows linearly with the size N of the marked object. In addition, we can augment our watermark-fingerprint system with a segmentation layer. The media content is partitioned into 5 segments, in which media players as well as forensic analyzers can reliably detect a watermark or fingerprint. Only detection keys that belong to the same segment can participate in the collusion clique. With segmentation, the minimum collusion size K grows as 0(N log N). Therefore, with or without segmentation, our watermark-fingerprint system significantly improves on the best-known asymptotic resistance to (fingerprint) collusion attacks of about O(N/sup 1/4/). Because we use a new protection protocol, comparing our system to classic fingerprint systems might seem unfair. However, such a comparison is important because the two technologies share a common goal: multimedia copyright enforcement. Our aim in this article is to characterize the collusion attacks against this system under the assumption that watermark detection is robust against signal-processing attacks on the protected object.
Preparation and Characterization of MAbs Against Different Epitopes of CD226 (PTA1) (2000)

Recently the platelet and T-cell activation antigen 1 (PTA1) was assigned as CD226 at the 7th Conference and Workshop on Human Leukocyte Differentiation antigens (HLDA). PTA1 is mainly expressed on activated T cells, natural killer (NK) cells, platelets and stimulated endotheliocytes, and involved in the differentiation of cytotoxic T lymphocytes (CTL) and NK, as well as platelet activation and aggregation. We raised hybridomas secreting monoclonal antibodies (MAbs) to PTA1 by using the natural PTA1 as immunogen, which was purified from platelets via affinity chromatography. These MAbs, designated FMU1, FMU2, FMU3, FMU4, FMU5, FMU6 and FMU7, could recognize PTA1 cDNA transfected COS7 cells detected by flow cytometry (FCM), and also react with both natural PTA1 and PTA1/Ig fusion protein in indirect enzyme-linked immunoadsorbent assay (ELISA). The biosensor epitope mapping assay showed that the seven MAbs, together with previous PTA1-specific MAbs Leo A1 and New E1, could bind seven distinct epitopes of PTA1, respectively. The panel of MAbs might be new powerful tools to study the structure-function relationship of PTA1 molecule, and to search for the ligand of PTA1.
A Novel Approach for Rogue Access Point Detection on the Client-Side (2012)

There is a big risk for public Wi-Fi users being tricked into connecting to rogue access points. Rogue access point is one of the most serious threats in WLAN, since it exposes a large number of users to MITM and evil twin attack. In this paper we propose a practical method that warns users to avoid connecting to the rogue access points. Proposed method compares the gateways and the routes that a packet travels to determine whether an access point is legitimate or not. This method can easily detect Man-In-The-Middle and evil twin attack without any assistance from the WLAN operator.
Purification and characterization of GDP‐<scp>D</scp>‐mannose 4,6‐dehydratase from porcine thyroid (1985)

The enzyme GDP-D-mannose 4,6-dehydratase has been purified 1500-fold from porcine thyroid tissue. The enzyme exhibits a molecular mass of 251000 Da as determined by sedimentation techniques. Its subunit size was determined as 41500 Da by dodecyl sulfate gel electrophoresis. The enzyme has a Km of 3.3 microM with respect to GDP-D-mannose and appears specific with respect to this substrate. The enzyme appears to be inhibited by guanine nucleotides and by guanine nucleotide sugars. It is particularly susceptible to inhibition by GDP-L-fucose. It is suggested that this compound may have a physiological function as an end-product feedback inhibitor.
5-Arylthio Substituted 2-Amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine Antifolates as Thymidylate Synthase Inhibitors and Antitumor Agents (1995)

Classical antifolate inhibitors of thymidylate synthase (TS) often require the reduced folate uptake system in order to exert their antitumor effects. In addition, these analogues are polyglutamylated via the enzyme folylpoly-gamma-glutamate synthetase (FPGS), which prevents analogue efflux from the cell and usually increases their inhibitory potency against TS. Impaired function of the reduced folate uptake system and that of FPGS are potential sources of resistance to such antifolates. We designed and synthesized a classical 6-5 ring-fused analogue N-[4-[(2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3- d]pyrimidin-5-yl)thio]-benzoyl]-L-glutamic acid (5) and a nonclassical 6-5 ring-fused analogue 2-amino-6-methyl-5-(pyridin-4-ylthio)-3,4-dihydro-4-oxo-7H-pyrrolo [2,3- d]pyrimidine (6) as TS inhibitors and antitumor agents. The syntheses of analogues 5 and 6 were achieved via the oxidative addition of the sodium salt of ethyl 4-mercaptobenzoate or 4-mercaptopyridine to 2-(pivaloylamino)-6-methyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyri midine (17) in the presence of iodine. For the synthesis of 5 the ester obtained from the reaction was deprotected and coupled with diethyl L-glutamate followed by saponification. Compound 5 was a potent inhibitor of human and bacterial TS with IC50 values of 42 and 21 nM, respectively. Compound 6 was 10-fold less potent than 5 against human TS but more than 4700-fold less potent than 5 against Lactobacillus casei TS. The classical analogue 5 was neither a substrate nor an inhibitor of human FPGS derived from CCRF-CEM cells. Compound 5 was cytotoxic to CCRF-CEM and FaDu tumor cell lines as well as to an FPGS-deficient subline of CCRF-CEM. Thymidine protection studies established that TS was the primary target of 5.