gebhart/patrepeval huggingface dataset:
Immersive Analytics (2015)

Immersive Analytics is an emerging research thrust investigating how new interaction and display technologies can be used to support analytical reasoning and decision making. The aim is to provide multi-sensory interfaces that support collaboration and allow users to immerse themselves in their data in a way that supports real-world analytics tasks. Immersive Analytics builds on technologies such as large touch surfaces, immersive virtual and augmented reality environments, sensor devices and other, rapidly evolving, natural user interface devices. While there is a great deal of past and current work on improving the display technologies themselves, our focus in this position paper is on bringing attention to the higher-level usability and design issues in creating effective user interfaces for data analytics in immersive environments.
In search of retrotransposons: exploring the potential of the PCR. (1992)

A rapid and universal procedure for isolating reverse transcriptase encoding elements from diverse mammalian genomes using PCR is described. We have designed short, degenerate primers to conserved amino acid domains of retroviral reverse transcriptase. These primers amplify a region, predicted to be 342-396 base pairs for most mammalian retroviruses, that spans several conserved domains of reverse transcriptase. The region encoded by the amplified PCR product contains a number of highly conserved amino acids that aid in identification of either degenerate reverse transcriptase or reverse transcriptase from new, undescribed elements. Additionally, these primers allow the amplification of a piece of DNA large enough to be used for phylogenetic analysis. The primers have been used successfully to isolate a region of three related reverse transcriptases from two mammalian taxa. The generality of this approach is discussed.
Removing coherent noise in seismic data through T‐K or F‐X filtering (1993)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1993Removing coherent noise in seismic data through T‐K or F‐X filteringAuthors: R. A. MeekA. F. LinvilleR. A. MeekMobil Exploration and Production Technical Center and A. F. LinvilleMobil Exploration and Production Technical Centerhttps://doi.org/10.1190/1.1822327 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1822327FiguresReferencesRelatedDetailsCited BySteps for Improving the Utility of Land Seismic Data for Unconventional ReservoirsChristof Stork28 September 2018 SEG Technical Program Expanded Abstracts 1993ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1993 Pages: 1396 publication data© 1993 Copyright © 1993 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION R. A. Meek and A. F. Linville, (1993), "Removing coherent noise in seismic data through T‐K or F‐X filtering," SEG Technical Program Expanded Abstracts : 1177-1180. https://doi.org/10.1190/1.1822327 Plain-Language Summary PDF DownloadLoading ...
A device and an algorithm for the separation of visible and near infrared signals in a monolithic silicon sensor (2010)

The Transverse Field Detector (TFD) is a filter-less and demosaicking-less color sensitive device that easily allows the design of more than three color acquisition channels at each pixel site. The separation of light into different wavelength bands is based on the generation of transverse electric fields inside the device depleted region, and exploits the properties of the Silicon absorption coefficient. In this work we propose such a device for the joint capture of visible and near infrared (NIR) radiation, for possible applications in videoconferencing and 3D imaging. In these applications the detector is used in combination with suitably generated NIR structured light. The information of the fourth acquisition channel, mainly capturing NIR signals, can be used both for sampling NIR light intensity and for subtracting unwanted NIR crosstalk from visible channels thus avoiding the need for the IR-blocking filter. Together with the presentation of a 4-channel sensor, a suitable algorithm for the processing of signals generated in the visible and infrared bands is described. The goal of the algorithm is to minimize the crosstalk of NIR radiation inside the visible channels and, simultaneously, to maintain good color reproduction and noise performance for the sensor, while holding a good sensitivity of the NIR channel up to 900 nm. The analysis indicates that the algorithm reduces the crosstalk of infrared signals inside R, G and B channels from 31%, 12% and 5% respectively to less than 2%. Concerning noise propagation, the worst coefficient of the color conversion matrix (CCM) is -2.1, comparable to those obtained for CCM of Bayer Color Filter Arrays.
Truck management systems review (1985)

The Canada Centre for Mineral and Energy Technology (CANMET), Calgary Coal Research Laboratory and the Canadian coal mining industry are preparing a jointly funded demonstration and evaluation of an integrated truck management system. This system will be installed and tested on two rear-dump off-highway mining trucks presently operating in a producing surface coal or oil sands mine. In the paper an overview of existing truck monitoring systems, presently available on the North American market is presented. All systems are evaluated based on their functions, diagnostics and integrated system control. The non-operator dependent on-board truck management system (OBDAS) is explained and recommended for field testing. The reasoning behind the selection of the OBDAS system is provided, as well as a discussion of the field testing proposal.
Optical Coherence Tomography of Animal Models of Retinitis Pigmentosa: From Animal Studies to Clinical Applications (2019)

Despite the various abnormal structural changes found in these different animal models, progressive thinning of the outer nuclear layer (ONL) and hyperreflective change in the inner and outer segment (IS-OS) layers of the photoreceptors were commonly observed on SD-OCT. In the rapidly progressive severe photoreceptor degeneration seen in rd10 and <i>Arr1</i> <sup><i>-/-</i></sup> mice, the ONL appeared hyperreflective. Electroretinography revealed various degrees of disease severity in these animal models. <i>Discussion and Conclusion</i>: SD-OCT is sensitive enough to detect even mild changes in the photoreceptor OS. Conversely, SD-OCT cannot qualitatively differentiate the pathologic and functional differences in the photoreceptors associated with different genetic abnormalities, with the exception of the rapid progression of severe forms of photoreceptor degeneration. These findings can be of value to understand better the clinical findings and the heterogeneous degenerative processes in patients with RP.
Tunable Fabry–Perot etalon-based long-wavelength infrared imaging spectroradiometer (1999)

Imaging spectrometry enables passive, stand-off detection and analysis of the chemical composition of gas plumes and surfaces over wide geographic areas. We describe the use of a long-wavelength infrared imaging spectroradiometer, comprised of a low-order tunable Fabry-Perot etalon coupled to a HgCdTe detector array, to perform multispectral detection of chemical vapor plumes. The tunable Fabry-Perot etalon used in this research provides coverage of the 9.5-14-microm spectral region with a resolution of 7-9 cm(-1). The etalon-based imaging system provides the opportunity to image a scene at only those wavelengths needed for chemical species identification and quantification and thereby minimize the data volume necessary for selective species detection. We present initial results using a brassboard imaging system for stand-off detection and quantification of chemical vapor plumes against near-ambient-temperature backgrounds. These data show detection limits of 22 parts per million by volume times meter (ppmv x m) and 0.6 ppmv x m for dimethyl methyphosphonate and SF6, respectively, for a gas/background DeltaT of 6 K. The system noise-equivalent spectral radiance is approximately 2 microW cm(-2) sr(-1) microm(-1). Model calculations are presented comparing the measured sensitivity of the sensor to the anticipated signal levels for two chemical release scenarios.
The measurement of ubiquitin and ubiquitinated proteins (1999)

Ubiquitination of key cellular proteins involved in signal transduction, gene transcription and cell-cycle regulation usually condemns those proteins to proteasomal or lysosomal degradation. Additionally, cycles of reversible ubiquitination regulate the function of certain proteins in a manner analogous to phosphorylation. In this short review we describe the current methodology for measuring ubiquitin and ubiquitination, provide examples which illustrate how various techniques have been used to study protein ubiquination, alert the readers of pitfalls to avoid, and offer guidelines to investigators newly interested in this novel post-translational protein modification.
Assembly and characterization of colloid-based antireflective coatings on multicrystalline silicon solar cells (2006)

Evaporation from a moving meniscus was used for controlled convective assembly of colloidal silica nanoparticles into antireflective coatings (ARCs) onto the rough uneven surfaces of polycrystalline silicon solar cells. The nanocoatings reduced the reflectance of the solar cells by approximately 10% across the near UV to near IR spectral range, which provided a 17% increase in the output power of the devices (which translated to a 10% relative increase in the efficiency). Microstructural analysis via SEM showed that while the surface coverage was uniform over long ranges, the thickness of the particle coatings varied locally due to the rough, undulating substrate surface. The UV/vis reflectance data of the silica coated solar cells could be modelled with the Fresnel reflectance relation by assuming a distributed range of thicknesses for the coatings, in good agreement with the microstructural data. We show that particulate films deposited on rough surfaces can function as ARCs even though they do not attain 0% reflectance. These silica particle-based coatings can be further modified by attachment of monolayers of fluorosilanes, which may make them superhydrophobic and/or self-cleaning.
Spin injection and spin accumulation in permalloy-copper mesoscopic spin valves (2001)

We study the electrical injection and detection of spin currents in a lateral spin valve device, using permalloy (Py) as ferromagnetic injecting and detecting electrodes and copper (Cu) as non-magnetic metal. Our multi-terminal geometry allows us to experimentally distinguish different magneto resistance signals, being 1) the spin valve effect, 2) the anomalous magneto resistance (AMR) effect and 3) Hall effects. We find that the AMR contribution of the Py contacts can be much bigger than the amplitude of the spin valve effect, making it impossible to observe the spin valve effect in a 'conventional' measurement geometry. However, these 'contact' magneto resistance signals can be used to monitor the magnetization reversal process, making it possible to determine the magnetic switching fields of the Py contacts of the spin valve device. In a 'non local' spin valve measurement we are able to completely isolate the spin valve signal and observe clear spin accumulation signals at T=4.2 K as well as at room temperature. We obtain spin diffusion lengths in copper of 1 micrometer and 350 nm at T=4.2 K and room temperature respectively.
Indigoferabietone, a novel abietane diterpenoid from Indigofera longeracemosa with potential antituberculous and antibacterial activity. (2002)

From the stems of Indigofera longeracemosa, a novel abietane diterpenoid, indigoferabietone was isolated. The structure was established by spectral techniques. The inhibitory activity of indigoferabietone (1) tested against Mycobacterium tuberculosis and Candida albicans, and the antibacterial activity tested against Staphylococcus aureus, Proteus vulgaris, and Escherichia coli were found to be significant.
A 60ns 4Mb DRAM in a 300mil DIP (1987)

THIS PAPER WILL DESCRIBE A 4Mb CMOS DRAM with a 60ns RAS access time and 4.54mm x 1.4.78mm (67.1mm2) chip area assembled in a 300mil dual-in-line plastic package. The RAM has been fabricated in a twin-tub CMOS process technology with double-poly, single-polycide and single-metal using a 0.8μm design rule
Role of rituximab in first-line treatment of chronic lymphocytic leukemia (2010)

Chronic lymphocytic leukemia (CLL) is a biologically heterogeneous illness that primarily afflicts the elderly. For many decades, the initial therapy for most patients requiring treatment was limited to single-agent alkylator therapy. Within the last two decades, we have seen remarkable progress in understanding the biology of CLL and the development of more effective treatment strategies that have employed monoclonal antibodies, such as rituximab (anti-CD20). Furthermore, recognition of the synergy between fludarabine, cyclophosphamide, and rituximab (FCR) prompted investigators to explore the clinical activity of FCR in Phase II and III trials in patients with relapsed/refractory or previously untreated CLL. On the basis of these findings, the US Food and Drug Administration (FDA) recently approved rituximab in combination with fludarabine and cyclophosphamide for the treatment of patients with relapsed/refractory or previously untreated CD20-postive CLL. Recent data from a randomized Phase III trial has confirmed improved overall survival with FCR in patients with previously untreated CLL. However, FCR is not for everyone. More tolerable regimens using rituximab for the elderly and less fit patients are being pursued in clinical trials. Recent Phase II trials have explored potentially less myelosuppressive approaches by using lower doses of fludarabine and cyclophosphamide, replacing fludarabine with pentostatin, and combining rituximab with chlorambucil. Furthermore new biomarkers predictive of early disease progression have prompted investigators to explore the benefits of early treatment with rituximab combined with other agents. In addition to the proven utility of rituximab as a frontline agent for CLL, rituximab has a favorable toxicity profile both as a single agent and in combination with chemotherapy. The majority of adverse events are Grade 1 and 2 infusion-related reactions (fevers, chills, and rigors) and occur with the first dose of rituximab. The improved tolerability observed with second and subsequent infusions allows for shorter infusion times. Rituximab's proven activity and favorable toxicity profile has made it an ideal agent for expanding treatment options for patients with CLL, the majority of whom are elderly.
Saliency-guided Enhancement for Volume Visualization (2006)

Recent research in visual saliency has established a computational measure of perceptual importance. In this paper we present a visual-saliency-based operator to enhance selected regions of a volume. We show how we use such an operator on a user-specified saliency field to compute an emphasis field. We further discuss how the emphasis field can be integrated into the visualization pipeline through its modifications of regional luminance and chrominance. Finally, we validate our work using an eye-tracking-based user study and show that our new saliency enhancement operator is more effective at eliciting viewer attention than the traditional Gaussian enhancement operator.
Identification of Three Subunits of the High Affinity ω-Conotoxin MVIIC-sensitive Ca2+ Channel (1996)

N-, P- and Q-type voltage-dependent Ca2+ channels control neurotransmitter release in the nervous system and are blocked by omega-conotoxin MVIIC. In this study, both a high affinity and a low affinity binding site for omega-conotoxin MVIIC were detected in rabbit brain. The low affinity binding site is shown to be present on the N-type Ca2+ channel. Using optimized conditions for specific labeling of the high affinity omega-conotoxin MVIIC receptor and a panel of subunit specific antibodies, the molecular structure of the high affinity receptor was investigated. We demonstrate for the first time that this receptor is composed of at least alpha1A, alpha2delta, and any one of the four brain beta subunits. Such association of different beta subunits with alpha1A and alpha2delta components may produce Ca2+ channels with distinct functional properties, such as P- and Q-type.
<i>In vitro</i> immunization to KLH. II. Limiting dilution analysis of antigen-reactive cells in primary and secondary culture. (1983)

Limiting dilution analysis was used to estimate the frequency of human peripheral blood T lymphocytes that proliferate in response to in vitro immunization with keyhole limpet hemocyanin (KLH). Antigen-reactive cells (ARC) were estimated 9 days after primary immunization with KLH. The ARC frequency of lymphocytes from 12 subjects ranged from 1:23,800 to 1:52,631. Lymphocytes from five of these subjects were also primed for 12 days with KLH, rechallenged in secondary culture with fresh adherent cells and KLH, and assayed 4 days later. The ARC frequency increased to 1:1,123 to 1:7,247, indicating that T cell clones responsive to KLH had expanded during primary culture. In addition, we observed that the proliferative response of lymphocytes from 5 of the 12 subjects were inhibited at high cell concentrations. Depletion of OKT8+ T cells before culturing with KLH however did not alter the inhibitory effect of high concentrations of T cells.
Metallic Soaps for Thickening Mineral Oils (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetallic Soaps for Thickening Mineral OilsC. J. BonerCite this: Ind. Eng. Chem. 1937, 29, 1, 58–60Publication Date (Print):January 1, 1937Publication History Published online1 May 2002Published inissue 1 January 1937https://pubs.acs.org/doi/10.1021/ie50325a009https://doi.org/10.1021/ie50325a009research-articleACS PublicationsRequest reuse permissionsArticle Views163Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics’ (2013)

A major obstacle to the efficient production of antibody conjugates for therapy and diagnosis is the non-ideal performance of commonly used chemical methods for the attachment of effector-molecules to the antibody of interest. Here we demonstrate that this limitation can be simply addressed using 3,4-substituted maleimides to bridge and thus functionalize disulfide bonds to generate homogeneous antibody conjugates. This one-step conjugation reaction is fast, site-specific, quantitative and generates products with full binding activity, good plasma stability and the desired functional properties. Furthermore, the rigid nature of this modification by disulfide bridging enables the successful detection of antigen with a spin labeled antibody fragment by continuous-wave electron paramagnetic resonance (cw-EPR), which we report here for the first time. Antigen detection is concentration dependent, observable in human blood and allows the discrimination of fragments with different binding affinity. We envisage broad potential for antibody based in-solution diagnostic methods by EPR or 'spinostics'.
Training deep neural networks via direct loss minimization (2016)

Supervised training of deep neural nets typically relies on minimizing cross-entropy. However, in many domains, we are interested in performing well on metrics specific to the application. In this paper we propose a direct loss minimization approach to train deep neural networks, which provably minimizes the application-specific loss function. This is often non-trivial, since these functions are neither smooth nor decomposable and thus are not amenable to optimization with standard gradient-based methods. We demonstrate the effectiveness of our approach in the context of maximizing average precision for ranking problems. Towards this goal, we develop a novel dynamic programming algorithm that can efficiently compute the weight updates. Our approach proves superior to a variety of baselines in the context of action classification and object detection, especially in the presence of label noise.
Bidirectional Crosstalk between the Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 Signaling Pathways in Breast Cancer: Molecular Basis and Clinical Implications (2013)

The estrogen receptor (ER) and/or the human epidermal growth factor receptor 2 (HER2) signaling pathways are the dominant drivers of cell proliferation and survival in the majority of human breast cancers. As a result, targeting these pathways provides the most effective therapies in appropriately selected patients. Nevertheless, resistance to both endocrine and anti-HER2 therapies occurs frequently and represents a major clinical challenge. Compelling preclinical and clinical evidence relates this treatment resistance to the presence of a complex bidirectional molecular crosstalk between the ER and HER2 pathways. As a consequence, treatment strategies targeting either pathway are associated with up-regulation of the other one, ultimately resulting in resistance to therapy. Therefore, a more promising strategy to prevent or overcome either endocrine or anti-HER2 resistance at least in some tumors is to combine targeted treatments that simultaneously block both signaling pathways. Many clinical trials exploring this strategy have shown positive results, and many more are currently ongoing. Future clinical trials with appropriate patient selection, based on biomarker evaluation of primary tumors and possibly of recurrent lesions, are warranted for the optimization of individualized therapeutic strategies.
Characteristics of protein splicing intrans mediated by a semisynthetic split intein (1999)

Protein splicing in trans results in the ligation of two protein or peptide segments linked to appropriate intein fragments. We have characterized the trans-splicing reaction mediated by a naturally expressed, approximately 100-residue N-terminal fragment of the Mycobacterium tuberculosis intein and a synthetic peptide containing the 38 C-terminal intein residues, and found that the splicing reaction was very versatile and robust. The efficiency of splicing was nearly independent of temperature between 4 and 37 degrees C and pH between 6.0 and 7.5, with only a slight decline at pH values as high as 8.5. In addition, there was considerable flexibility in the choice of the C-terminal intein fragment, no significant difference in protein ligation efficiency being observed between reactions utilizing the N-terminal fragment and either the naturally expressed 107-residue C-terminal portion of the intein, much smaller synthetic peptides, or the 107-residue C-terminal intein fragment modified by fusion of a maltose binding protein domain to its N-terminus. The ability to use different types of the C-terminal intein fragments and a broad range of reaction conditions make protein splicing in trans a versatile tool for protein ligation.