gebhart/patrepeval huggingface dataset:
Annual Review of Work in Newspaper and Periodical History (2000)

(2000). Annual Review of Work in Newspaper and Periodical History. Media History: Vol. 6, No. 1, pp. 81-92.
Influence of format on in vitro penetration of antibody fragments through porcine cornea (2005)

Antibody fragments of different shapes and sizes can penetrate the cornea after topical administration, thereby increasing the potential of this class of proteins for topical ophthalmic use.
Modulation of Cancer Traits by Tumor Suppressor microRNAs (2013)

MicroRNAs (miRNAs) are potent post-transcriptional regulators of gene expression. In mammalian cells, miRNAs typically suppress mRNA stability and/or translation through partial complementarity with target mRNAs. Each miRNA can regulate a wide range of mRNAs, and a single mRNA can be regulated by multiple miRNAs. Through these complex regulatory interactions, miRNAs participate in many cellular processes, including carcinogenesis. By altering gene expression patterns, cancer cells can develop specific phenotypes that allow them to proliferate, survive, secure oxygen and nutrients, evade immune recognition, invade other tissues and metastasize. At the same time, cancer cells acquire miRNA signature patterns distinct from those of normal cells; the differentially expressed miRNAs contribute to enabling the cancer traits. Over the past decade, several miRNAs have been identified, which functioned as oncogenic miRNAs (oncomiRs) or tumor-suppressive miRNAs (TS-miRNAs). In this review, we focus specifically on TS-miRNAs and their effects on well-established cancer traits. We also discuss the rising interest in TS-miRNAs in cancer therapy.
Hearing loss and erythromycin pharmacokinetics in a patient receiving hemodialysis (1983)

• A left upper lobe pneumonia developed in a patient who was receiving hemodialysis; he was treated intravenously with 1 g of erythromycin lactobionate every six hours. After five doses, hearing loss was noted; this was later documented by audiogram. Erythromycin serum concentrations as high as 100 mg/L and a half-life more than three times longer than normal were observed. To our knowledge, this represents the first report of reversible hearing loss associated with elevated serum erythromycin concentrations and prolonged serum half-life. (<i>Arch Intern Med</i>1983;143:1263-1265)
Simple Method for Determining the Caloric and Fat Content of Human Milk (1980)

The Committee on Nutrition of the American Academy of Pediatrics has recently advocated breast-feeding for the normal, full-term newborn, unless contraindicated for specific reasons (including a desire by the mother not to breast-feed) or when breast-feeding is unsuccessful.1 This recommendation reflects the renewed interest throughout the world in providing human milk to the healthy infant. Further, expressed breast milk (either from the infant's mother or from donors) is being fed with increased frequency to the preterm or sick infant.2,3 The adequacy of human milk to meet the nutritional needs of all preterm babies has not been documented, however, as recently reviewed by Fleischman and Finberg.4
Piecewise Parabolic Approximate Computation Based on an Error-Flattened Segmenter and a Novel Quantizer (2021)

This paper proposes a novel Piecewise Parabolic Approximate Computation method for hardware function evaluation, which mainly incorporates an error-flattened segmenter and an implementation quantizer. Under a required software maximum absolute error (MAE), the segmenter adaptively selects a minimum number of parabolas to approximate the objective function. By completely imitating the circuit’s behavior before actual implementation, the quantizer calculates the minimum quantization bit width to ensure a non-redundant fixed-point hardware architecture with an MAE of 1 unit of least precision (ulp), eliminating the iterative design time for the circuits. The method causes the number of segments to reach the theoretical limit, and has great advantages in the number of segments and the size of the look-up table (LUT). To prove the superiority of the proposed method, six common functions were implemented by the proposed method under TSMC-90 nm technology. Compared to the state-of-the-art piecewise quadratic approximation methods, the proposed method has advantages in the area with roughly the same delay. Furthermore, a unified function-evaluation unit was also implemented under TSMC-90 nm technology.
Highly Reliable Inter/Intra-Stream FEC Method for Multi-Server Content Distribution (2010)

To establish seamless and highly robust contents distribution technology in the environment of so-called multiserver contents distribution network, we focus on the Forward Error Correction (FEC) as an error recovery method, and we have proposed the new concept, Inter-Stream FEC, that means data recovery method between several streams by introducing redundant parity streams generated by inter-stream cooperation. In this paper, we extensively improve the proposed basic method. We focus on the recovery failure events in the original InterStream FEC method, and propose its remedy. The proposed method makes existing FEC and Inter-Stream FEC cooperate deeply and this leads to higher loss recovery ratio. Besides, we evaluate the basic method and the extensively proposed method through computer simulation and confirm that proposal can improve recovery capability.
Genome, Functional Gene Annotation, and Nuclear Transformation of the Heterokont Oleaginous Alga Nannochloropsis oceanica CCMP1779 (2012)

Unicellular marine algae have promise for providing sustainable and scalable biofuel feedstocks, although no single species has emerged as a preferred organism. Moreover, adequate molecular and genetic resources prerequisite for the rational engineering of marine algal feedstocks are lacking for most candidate species. Heterokonts of the genus Nannochloropsis naturally have high cellular oil content and are already in use for industrial production of high-value lipid products. First success in applying reverse genetics by targeted gene replacement makes Nannochloropsis oceanica an attractive model to investigate the cell and molecular biology and biochemistry of this fascinating organism group. Here we present the assembly of the 28.7 Mb genome of N. oceanica CCMP1779. RNA sequencing data from nitrogen-replete and nitrogen-depleted growth conditions support a total of 11,973 genes, of which in addition to automatic annotation some were manually inspected to predict the biochemical repertoire for this organism. Among others, more than 100 genes putatively related to lipid metabolism, 114 predicted transcription factors, and 109 transcriptional regulators were annotated. Comparison of the N. oceanica CCMP1779 gene repertoire with the recently published N. gaditana genome identified 2,649 genes likely specific to N. oceanica CCMP1779. Many of these N. oceanica-specific genes have putative orthologs in other species or are supported by transcriptional evidence. However, because similarity-based annotations are limited, functions of most of these species-specific genes remain unknown. Aside from the genome sequence and its analysis, protocols for the transformation of N. oceanica CCMP1779 are provided. The availability of genomic and transcriptomic data for Nannochloropsis oceanica CCMP1779, along with efficient transformation protocols, provides a blueprint for future detailed gene functional analysis and genetic engineering of Nannochloropsis species by a growing academic community focused on this genus.
Braucht es ein Unternehmensjuristengesetz (2009)

Seit langem wird die Frage kontrovers diskutiert, ob sich eine bei einem Unternehmen angestellte Rechtsanwältin bei behördlich angeordneter Aktenedition auf ein Mitwirkungsverweigerungsrecht berufen kann. Bei dieser Diskussion werden möglicherweise verschiedene Aspekte vermischt, die getrennt voneinander dargestellt werden müssten: Insbesondere wird oft verkannt, dass nicht die strafrechtlichen Schutzbestimmungen die Grundlagen für ein Berufsgeheimnis darstellen, sondern dass diese vielmehr in den jeweiligen zivilrechtlichen Verhältnissen zu suchen sind.
Purification and characterization of the DNA polymerase of human breast cancer particles. (1977)

Previous studies have identified human breast tumor particles possessing many of the features characteristic of RNA tumor viruses. In addition to the expected size (600 S) and density (1.16 g/ml) these include possession of an outer membrane and an inner one surrounding a "core" containing a DNA polymerase and a large-molecular-weight (70S) RNA possessing detectable homology to the RNAs of the mouse mammary tumor virus (MMTV) and of the Mason-Pfizer monkey virus (MPMV). We report here the purification and characterization of the DNA polymerase from the human breast cancer particles. Its key properties are very similar to those ofthe RNA-dependent DNA nucleotidyltransferase (reverse transcriptase) found in MMTV and MPMV. Thus like these viral enzymes, the purified human breast cancer DNA polymerase exhibits the following three features that together distinguish the known viral reverse transcriptases from normal cellular DNA polymerases: (i) a strong preference for oligo(dT)-poly(rA) over oligo(dT)-poly(dA) as a template for the synthesis of poly(dT); (ii) the acceptance of the highly specific oligo(dG)-poly(rCm) as a template for the formation of poly(dG); (iii) the ability to use a viral RNA (AMV) as a template to fashion a faithful DNA complementary copy; and (iv) its preference for Mg++ over Mn++. In summary, the data described here on the enzyme of the human breast cancer particles add further evidence of similarities to the viral agents associated with the corresponding malignancies in the mouse and monkey models. To date, an enzyme with these properties has not been detected in normal breast tissues or in benign tumors of the breast.
Smart Recommendation for an Evolving E-Learning System: Architecture and Experiment (2005)

In this paper, we proposed an evolving e-learning system which can adapt itself both to the learners and the open the web and pointed out the differences of making recommendations in e-learning and other domains. We propose two pedagogy features in recommendation: learner interest and background knowledge. A description of paper value, similarity, and ordering are presented using formal definitions. We also study two pedagogy-oriented recommendation techniques: content-based and hybrid recommendations. We argue that while it is feasible to apply both of these techniques in our domain, a hybrid collaborative filtering technique is more efficient to make “just-in-time” recommendations. In order to assess and compare these two techniques, we carried out an experiment using artificial learners. Experiment results are encouraging, showing that hybrid collaborative filtering, which can lower the computational costs, will not compromise the overall performance of the RS. In addition, as more and more learners participate in the learning process, both learner and paper models can better be enhanced and updated, which is especially desirable for web-based learning systems. We have tested the recommendation mechanisms with real learners, and the results are very encouraging.
ERBB3-Independent Activation of the PI3K Pathway in EGFR-Mutant Lung Adenocarcinomas (2015)

ERBB3, a member of the EGFR family of receptor tyrosine kinases, has been implicated in activation of the PI3K pathway in human lung adenocarcinomas driven by EGFR mutations. We investigated the contribution of ERBB3 to the initiation, progression, and therapeutic response of EGFR-induced lung adenocarcinomas using tetracycline- and tamoxifen-inducible transgenic mouse models. Deletion of Erbb3 at the time of induction of mutant EGFR had no effect on tumorigenesis, demonstrating that ERBB3 is not required to initiate tumorigenesis. Tumors that developed in the absence of ERBB3 remained sensitive to EGFR tyrosine kinase inhibitors and retained activation of the PI3K-AKT pathway. Interestingly, acute loss of Erbb3 suppressed further growth of established EGFR(L858R)-mediated lung tumors. Four weeks after deletion of Erbb3, the tumors exhibited phosphorylation of EGFR, of the adaptor proteins GAB1 and GAB2, and of the downstream signaling molecules AKT and ERK, suggesting that alternative signaling pathways could compensate for loss of Erbb3. Similar to our observations with mouse tumors, we found that GAB adaptor proteins play a role in ERBB3-independent activation of the PI3K pathway by mutant EGFR in EGFR-mutant human cell lines. Finally, in such cell lines, increased levels of phosphorylation of ERBB2 or MET were associated with reduced sensitivity to acute loss of ERBB3, suggesting remarkable plasticity in the signaling pathways regulated by mutant EGFR with important therapeutic implications.
The Rationale and Management of Hyperglycemia for In-Patients with Cardiovascular Disease: Time for Change (2003)

There is increasing evidence that aggressive glycemic control for patients admitted into the hospital improves clinical outcomes, especially for patients with cardiovascular disease. There appear to be a variety of mechanisms for this. Although hyperglycemia has been shown to result in poor wound healing and more infectious complications, especially after cardiac surgical procedures, what has become clear is that the treatment of hyperglycemia with i.v. glucose, insulin, and potassium (GIK) results in better clinical outcomes even in patients without diabetes. The mechanisms for this are not year clear, but could be related to the insulin administration, perhaps due to suppression of various cytokines or free fatty acids. The practical use of insulin in these patients requires basic understanding of the use of both i.v. and s.c. insulin. Although there are several appropriate options for both of these routes of administration, it is critical that all caregivers involved in this population's care are knowledgeable about insulin strategies.
Influence de la complexation sur la réactivité de nitrates d'halogènes (1989)

Iodine nitrate or bromine nitrate in acetonitrile or in chloroform react with a variety of phenolic substrates to form both halogenated and nitrated products. In the presence of strong complexing agents of halonium ions, no reaction occurs, while in the presence of pyridine or triethylamine, only halogenated phenols exhibiting a strong ortho-directing effect of the phenolic function are produced. Keywords: phenols, iodine nitrate, bromine nitrate, halogenation, nitration.
Struktur und Entstehung der Larven- und Puppengehäuse einiger Glossosomatidae und Rhyacophilidae, insbesondere bei Synagapetus iridipennis (Trichoptera: Rhyacophiloidea) (1983)

Quand S. i. construit un nouveau fourreau larvaire, en general celui-ci est fabrique comme une annexe du precedent. Quand sa taille atteint au moins la moitie de sa longueur definitive, les jonctions de soie entre la partie ancienne et la partie nouvelle sont coupees
Molecular Neuroanatomy of 5-HT Receptors (1991)

Serotoninergic terminals are found throughout the brain, suggesting an involvement of 5-HT in many brain functions. The effects of 5-HT on a given neuron are dependent on the different types of receptors expressed by this neuron, their location on the neuron and the signal transduction mechanism used. In order to provide information on the localization of 5-HT receptors both at the regional and cellular levels, we have combined ligand binding and in situ hybridization autoradiography to identify neurons expressing the different 5-HT receptor mRNAs and to localize 5-HT binding sites. The information gathered is discussed with reference to functional data in some well characterized anatomical systems: the striato-nigral pathway, the hippocampal formation and the brainstem, with special emphasis on the cranial nerve nuclei.
Automated segmentation of gingival diseases from oral images (2017)

Periodontal diseases are the largest cause of tooth loss among people of all ages and are also correlated with systemic diseases such as endocarditis. Advanced periodontal disease comprises degradation of surrounding tooth structures, severe inflammation and gingival bleeding. Inflammation is an early indicator of periodontal disease. Early detection and preventive measures can help prevent serious occurrences of periodontal diseases and in most cases restore oral health. We report a machine learning classifier, trained with annotations from dental professionals, that successfully provides pixel-wise inflammation segmentations of color-augmented intraoral images. The classifier successfully distinguishes between inflamed and healthy gingiva and its area under the receiver operating characteristic curve is 0.746, with precision and recall of 0.347 and 0.621 respectively. Dental professionals and patients can benefit from automated point-of-care early diagnosis of periodontal diseases provided by this classifier using oral images acquired by intraoral imaging devices.
Dislocation Etch for (100) Planes in Silicon (1972)

A new etch composed of a dilute aqueous solution of an alkali dichromate and hydrofluoric acid, for suitably revealing dislocations and other lattice defects in (100) planes of silicon, is reported. The etch is fast (typically 5 min), brings out both lineage (low angle grain boundaries) and slip lines, and works over a wide range of resistivities for n‐ and p‐type material. The application of the etch is not restricted to (100) planes; dislocation etch pits are formed on all crystallographic orientations. The same etching characteristics were found with dilute aqueous solutions prepared from various chromium compounds and hydrofluoric acid.
Excitonic Effects and Optical Spectra of Single-Walled Carbon Nanotubes (2004)

Many-electron effects often dramatically modify the properties of reduced dimensional systems. We report calculations, based on an ab initio many-electron Green's function approach, of electron-hole interaction effects on the optical spectra of small-diameter single-walled carbon nanotubes. Excitonic effects qualitatively alter the optical spectra of both semiconducting and metallic tubes. Excitons are bound by approximately 1 eV in the semiconducting (8,0) tube and by approximately 100 meV in the metallic (3,3) tube. These large many-electron effects explain the discrepancies between previous theories and experiments.
Homogeneous pinhole free 1 nm Al2O3 tunnel barriers on graphene (2012)

We report on the topographical and electrical characterisations of 1 nm thick Al2O3 dielectric films on graphene. The Al2O3 is grown by sputtering a 0.6 nm Al layer on graphene and subsequentially oxidizing it in an O2 atmosphere. The Al2O3 layer presents no pinholes and is homogeneous enough to act as a tunnel barrier. A resistance-area product in the mega-ohm micrometer-square range is found. Comparatively, the growth of Al2O3 by evaporation does not lead to well-wetted films on graphene. Application of this high quality sputtered tunnel barrier to efficient spin injection in graphene is discussed.
Three-Component Coupling Synthesis of Prostaglandins: The Aldol Route (1988)

Abstract A one-pot, high yield construction of the whole prostaglandin (PG) skeleton is accomplishable by combination of the copper-mediated conjugate addition of an ω side-chain unit to a 4R-oxygenated 2-cyclopentenone derivative and aldol condensation of the in situ generated enolate with an α side-chain aldehyde. Subsequent removal of the 7-hydroxyl group from the adducts and deblocking of the protective groups give PGs of E series. PGE1 has been prepared in 56% overall yield through the five-step sequence. Selective transformation of the PGE to PGD structure can be realized simply by appropriate selection of the hydroxyl protective groups in the five-membered ring and ω side-chain units. The vicinal carba-condensation using methyl 6-formyl-5-hexynoate as the α side-chain aldehyde unit followed by deoxygenation from the aldol products gives the 5,6-didehydro-PGE2 derivatives which serve as key intermediates in the general synthesis of various natural PGs. An efficient method for resolution of 4-hydroxy-2-cyclopentenone is also described.
3D TV projection (1987)

Work being carried out at the Heinrich-Hertz Institut in Berlin could lead to the development of large-screen three-dimensional TV
Relationship between IL 2 synthesis and the proliferative response to PHA in different primary immunodeficiencies. (1982)

Abstract In PBM obtained from 24 immunodeficient patients (two severe combined immunodeficiencies, three cases of Wiskott-Aldrich syndrome, two immunodeficiencies with hyper IgM, three cases of X-linked agammaglobulinemia, and 14 common variable immunodeficiencies) and from 19 age-matched controls, we have studied 1) the proliferative response to optimal and suboptimal doses of PHA after “in vitro” supplementation of the cultures with mitogen-free supernatants containing II 2 (IL 2 Sup), and 2) the production of IL 2 in response to an optimal dose of PHA. Addition of IL 2 Sup to cultures of normal PBM stimulated with 1% or 0.05% PHA did not cause significant augmentation of proliferative response, and only at a very low PHA dose (0.02%) did the addition of IL 2 Sup induce an increment of the DNA synthesis. On the other hand, addition of IL 2 Sup to lymphocytes from immunodeficient patients stimulated with the suboptimal dose of PHA (0.05%) caused an enhancement of the DNA synthesis, which in most cases never reached the levels observed in normal individuals, and was more manifest in those patients who showed a PHA response below the normal level. The production of IL 2 was significantly lower (p &lt; 0.01) in the immunodeficient patients with a reduced proliferative response to PHA, and was in the normal range (p &lt; 0.03) in immunodeficient patients with a normal or borderline PHA response. When all the data from controls and patients were pooled for regression analysis, a significant correlation was found between DNA synthesis and IL 2 production (r = + 0.64, p &lt; 0.01 ), between DNA synthesis and its enhancement after IL 2 Sup addition (r = − 0.48, p &lt; 0.01 ), and between IL 2 production and the enhancement of DNA synthesis after IL 2 Sup addition (r = − 0.48, p &lt; 0.01). The main conclusion is that the hyporesponse to PHA, in our group of immunodeficient patients, is associated with, but not exclusively due to, a defect in the production of IL 2.
The Preparation and Characterization of 1-Phosphohistidine and 3-Phosphohistidine<sup>*</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation and Characterization of 1-Phosphohistidine and 3-Phosphohistidine*D. E. Hultquist, R. W. Moyer, and P. D. BoyerCite this: Biochemistry 1966, 5, 1, 322–331Publication Date (Print):January 1, 1966Publication History Published online1 May 2002Published inissue 1 January 1966https://pubs.acs.org/doi/10.1021/bi00865a041https://doi.org/10.1021/bi00865a041research-articleACS PublicationsRequest reuse permissionsArticle Views792Altmetric-Citations172LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts