gebhart/patrepeval huggingface dataset:
Arginine vasopressin potentiates adrenocorticotropin release induced by ovine corticotropin-releasing factor. (1984)

Arginine vasopressin (AVP) stimulates ACTH release in man and acts synergistically with synthetic ovine corticotropin-releasing factor (oCRF) in vitro. This study was designed to examine in man the combined effects of synthetic AVP (10 U intramuscularly) and oCRF (1 micrograms/kg intravenously) on ACTH release. Five normal male volunteers participated in five separate experiments: (a) AVP alone; (b) oCRF alone; (c) AVP followed by oCRF 15 min later; (d) simultaneous AVP and oCRF; and (e) insulin-induced hypoglycemia. Plasma immunoreactive ACTH (IR-ACTH) and IR-cortisol were measured for 4 h after injection of each hormone; basal levels for all subjects were less than or equal to 9 +/- 1.2 pg/ml and 4.9 +/- 0.4 micrograms/dl (mean +/- SE), respectively. AVP and oCRF, when given individually, caused rapid rises in IR-ACTH to similar peak levels of 25 +/- 6.6 and 33 +/- 4.6 pg/ml, respectively. AVP given 15 min before oCRF caused a 2.6-fold potentiation of the oCRF response, with a peak IR-ACTH of 85 +/- 4.6 pg/ml. AVP given at the same time as oCRF produced a fourfold potentiation of the peak IR-ACTH response to 132 +/- 11 pg/ml. These ACTH responses were far greater than those previously observed after 30-fold greater doses of oCRF alone. By way of comparison, insulin-induced hypoglycemia caused a peak IR-ACTH of 169 +/- 20 pg/ml. IR-ACTH returned to base line at 60-90 min after AVP alone, whereas the prolonged effect of oCRF was apparent whether it was given alone or in combination with AVP. The mean peak IR-cortisol responses to AVP, oCRF, and AVP given 15 min before oCRF were similar (16.5 +/- 0.9, 16.4 +/- 2.3, and 18.5 +/- 0.8 micrograms/dl, respectively), but the peak IR-cortisol responses to AVP and oCRF given simultaneously and to insulin-induced hypoglycemia were 1.5 and 1.7 times greater, respectively. IR-cortisol returned to base line within 2-3 h after AVP alone, but remained elevated for at least 4 h after oCRF alone or in combination with AVP. These results indicate that AVP acts synergistically with oCRF to release ACTH in man and suggest that AVP may play a physiologic role in modulating the ACTH response mediated by corticotropin-releasing factor.
Kinetics, isotope effects, and mechanism of the hydrogenation of carbon monoxide on a supported palladium catalyst (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics, isotope effects, and mechanism of the hydrogenation of carbon monoxide on a supported palladium catalystToshiaki Mori, Hiroyuki Masuda, Hisao Imai, Akira Miyamoto, Ren Hasebe, and Yuichi MurakamiCite this: J. Phys. Chem. 1983, 87, 19, 3648–3652Publication Date (Print):September 1, 1983Publication History Published online1 May 2002Published inissue 1 September 1983https://pubs.acs.org/doi/10.1021/j100242a016https://doi.org/10.1021/j100242a016research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Data processing and quasi-3D optoacoustic imaging of tumors in the breast using a linear arc-shaped array of ultrasonic transducers (2008)

We developed an improved signal and image processing of optoacoustic data collected by our laser optoacoustic imaging system designed for breast cancer detection (LOIS-B). The implemented wavelet-based signal processing allowed significant reduction of the low-frequency acoustic noise, improved contrast and localization of the optoacoustic sources of interest. The system was able to differentiate phantoms mimicking breast tumors based on the contrast and morphology of their images. The implemented wavelet-based signal processing also facilitated high (0.5 mm) resolution of the phantoms mimicking parallel blood vessels in the presence of large-amplitude low-frequency acoustic artifacts. The application of the 3D radial back projection image reconstruction algorithm allowed visulaization of the tumor phantoms located beyond the imaging slice of the arc-shaped array of transducers. The visualization of slices parallel to the array of transducers with individual adjustment of the image palette for each particular slice eliminated the image artifacts caused by the large gradient of the laser fluence orthogonal to the array of transducers.
La population âgée hémodialysée : évaluer et prendre en charge le risque de déclin cognitif (2006)

Epidemiological data suggest a large prevalence of cognitive impairment in elderly patients on haemodialysis. They are frequently exposed to pathologies that affect the brain, and hold a plurality of risk factors for neurodegenerative and vascular dementia. Cognitive dysfunctions, because of their medical and socio-economical consequences, may led to discuss the indication for haemodialysis and its profit for the elderly patient. These facts highlight the advantage of a regular assessment of cognitive functions in this population. They also suggest the need in the future of a multidisciplinary intervention for these patients, for a better evaluation of interventions aimed on primary and secondary prevention of cognitive decline in the elderly group.
Peptide‐specific ctl in tumor‐infiltrating lymphocytes from metastatic melanomas expressing mart‐1/melan‐a, gp100 and tyrosinase genes: A study in an unselected group of hla‐a2.1‐positive patients (1995)

Peptide specificity of cultured tumor-infiltrating lymphocytes (TIL) was systematically investigated in a group of HLA-A2.1+ metastatic melanoma patients consecutively referred to our department for surgical treatment. Seven samples from 6 patients were studied. All surgical specimens showed evidence of gp 100, MART-1/Melan-A and Tyrosinase gene expression as detectable by reverse PCR (rPCR). Cultured TIL from 2 patients displayed cytotoxic activity against autologous or HLA-matched EBV-transformed cells previously pulsed with MART-1/Melan-A27-35 peptide. In contrast, no CTL activity against gp100(280-288) or tyrosinase1-9 peptides could be observed. TIL were then repeatedly stimulated in vitro with the same peptides. After 6 restimulation courses at weekly intervals, specific recognition of gp100(280-288) and MART-1/Melan-A peptides was detectable in 3 and 5 TIL populations, respectively. In one case Tyrosinase1-9-specific CTL could be demonstrated. Two TIL populations from metastases resected from a melanoma patient at 6 months' distance showed a different peptide specificity pattern, and no specific CTL could be generated from simultaneously sampled peripheral blood mononuclear cells (PBMC). All peptide-specific CTL populations also displayed significant cytotoxic activity against HLA-A2.1 matched melanoma cell lines expressing the antigens under investigation. Our data indicate that CTL specific for MART-Melan-A27-35, gp100(280-288) or Tyrosinase1-9 peptides could be expanded with varying frequency from TIL derived from 4 out of 6 HLA-A2.1+ patients whose tumors expressed the genes encoding these tumor-associated antigens (TAA).
Stability, Disposition, and Penetration of Catalytic Antioxidants Mn-Porphyrin and Mn-Salen and of Methylprednisolone in Spinal Cord Injury (2012)

This study measured the time courses of concentration changes following administration of the catalytic antioxidants Mn (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) and Mn (III) 3-methoxy N, N' bis (salicyclidene) ethylenediamine chloride (EUK-134) in blood and cerebrospinal fluid (CSF) of rats with a spinal cord injury (SCI) and sham controls. Parallel measurements were made for methylprednisolone, the only drug presently used clinically for treating SCI. The time courses kinetically characterized the agents in their stability, disposition, and ability to penetrate the blood-spinal cord barrier (BSB). In both the SCI and control groups, MnTBAP was stable in CSF and in blood across the collection periods (10 h and 24 h, respectively) following administration. In the blood, [EUK-134] and [methylprednisolone] rapidly declined to near basal concentrations at 4 h and 2 h, respectively, post-administration. Therefore the order of stability in CSF and blood was MnTBAP >> EUK-134 > methylprednisolone. The maximum CSF/blood concentration ratios for EUK-134, methylprednisolone and MnTBAP post-administration were: 32 ± 3.1%, 19.2 ± 6.4%, and 4.42 ± 0.73% in the injured rats, and 22 ± 6.5%, 17.8 ± 2.9%, and 1.0 ± 0.5% in the sham control animals. This suggests an order of BSB penetration of EUK-134 > methylprednisolone >> MnTBAP. Despite much lower penetration by MnTBAP compared with EUK-134 and methylprednisolone, a lower dose of MnTBAP because of its stability provided a higher concentration in CSF than did the other agents given at higher doses. This finding supports further exploration of MnTBAP as a potential treatment for SCI.
Iterative demodulation and decoding for parallel combinatorial SS systems (2002)

This paper proposes iterative demodulation/decoding for parallel combinatorial spread spectrum (PC/SS) systems. The PC/SS systems convey the information data by a combination of pre-assigned spreading sequences with polarity. Convolutional coding with a random interleaver is implemented as channel coding, like serial concatenated coding. A 'soft-in/soft-out' PC/SS demodulator, based on an a posteriori probability algorithm, is proposed to perform the iterative demodulation and decoding. Simulation results demonstrate that the proposed iterative demodulation and decoding bring significant improvement in the bit error rate performance.
A monoclonal antibody that recognizes a cluster of a disaccharide, NeuAc alpha(2—-6)GalNAc, in mucin-type glycoproteins. (1988)

The structure of an epitopic carbohydrate recognized by a monoclonal antibody, MLS 102, was determined. A disaccharide, NeuAc alpha (2----6)GalNAc, the major prosthetic group of ovine submaxillary mucin (OSM) and related synthetic glycosides, NeuAc alpha(2----6)GalNAc alpha----Ser, NeuAc alpha(2----6)GalNAc beta----Ser, and NeuAc alpha (2----6)GalNAc beta----propyl, reacted with MLS 102 to similar extents, but the reaction was considerably weaker compared to that of OSM. This difference in reactivity could be ascribed to the occurrence of a cluster of the disaccharide on OSM. Purification of MLS 102-reactive antigens from a Triton X-100 extract of LS 180 cells by means of immunoaffinity chromatography gave mucin fractions (cMLS 102 antigen) with an OSM-like domain. Correlation between the content of the disaccharide, NeuAc alpha(2----6)GalNAc, in mucins and their reactivity with MLS 102 was observed.
Gestural interface to a visual computing environment for molecular biologists (2002)

In recent years there has been tremendous progress in 3-D, immersive display and virtual reality (VR) technologies. Scientific visualization af data is one of many applications that has benefited from this progress. To fully exploit the potential of these applications in the new environment there is a need for "natural" interfaces that allow the manipulation of such displays without burdensome attachments. This paper describes the use of visual hand gesture analysis enhanced with speech recognition for developing a bimodal gesture/speech interface for controlling a 3-D display. The interface augments an existing application, VMD, which is a VR visual computing environment for molecular biologists. The free hand gestures are used for manipulating the 3-D graphical display together with a set of speech commands. We concentrate on the visual gesture analysis techniques used in developing this interface. The dual modality of gesture/speech is found to greatly aid the interaction capability.
Collisions need not be dangerous for elliptical and flexible vehicles (2002)

We claim collisions need not be harmful for vehicles. If vehicles are designed to be elliptical and flexible, they need not suffer from damage due to collision. Additionally, wheel slippage can be reduced or avoided, if the vehicle's motors are switched off immediately when a collision occurs. This is because an appropriate elliptical shape transforms the repulsive collision force onto the vehicle's surface into a repulsive torque about the vehicle's center of rotation (COR). This torque turns the vehicle away from the collision region, thereby releasing the contact pressure and reducing the collision force. We realized such an elliptical, flexible vehicle by attaching an elliptical, flexible bumper system (TUMBLER) to our small-sized experimental mobile robot YAMABICO. We confirmed by simulation the slippage-avoiding behavior in vehicle-wall collisions up to a speed of 0.5 m/s. We further confirmed by real vehicle-vehicle collision experiments the damage-avoidance feature up to a speed of 0.75 m/s. A similar behavior for large-sized vehicles and higher velocities (e.g. street vehicles) can be expected.
A Comparison of Income Level and Work-Related Fatalities for Finding Causes and Measures for Construction Sector (2014)

소득수준이 높으면 이와 함께 사회 경제 문화적 기대수준도 함께 향상되는 것이 일반적이며, 산업안전에 대한 기대수준도 함께 높아질 것이다. 그러나 우리나라는 소득수준은 그동안 많이 향상되었으나, 산재사망률은 OECD국가 중 가장 높은 수준이며 산재사망이 지난 10여년간 전혀 줄어들고 있지 않고 있다. 본 연구는 우리나라의 소득수준 대비 산재사망률을 관련 국가들과 비교하고 그 차이점을 분석하여 근로자 중심의 산재예방 대책의 문제점을 파악하고 이에 대한 적절한 대책을 제시하는 것을 목적으로 하여 진행되었으며, 이를 위해 소득반영 산재사망지수를 제시하였다. 그 결과 우리나라의 경우 비교국가 중에 그 수치가 가장 높게 나타났으며, 그 원인에 대한 분석의 일환으로 산업재해에 대한 법집행실적에 대한 비교를 한 결과 위반 사업주에 대한 법집행에 중점을 두는 영국의 경우와는 달리 우리나라의 법집행 실적은 상대적으로 낮은 편으로 나타나 건설공사의 안전성 향상을 위해서는 향후 법집행 강화의 필요한 것으로 나타났다. As the income level of a country gets improved, people's social, economic, and cultural expectation will grow at the same time. Although the income level of Korea has been remarkably improved, her work-related fatality rate is the highest among OECD countries. Moreover, the rate hasn't been reduced for more than 10 years. This study aims to provide appropriate measures for work-related fatality reduction by comparing the income levels and the work-related fatality rates of countries and by analysing the problems of our worker-oriented accident prevention policy. For the comparison of income level and work-related fatalities, this study suggests income-level incorporated fatality rate, and it turned out that the rate of Korea is the highest among the countries. In order to find out the causes of that result, this study has found that our law enforcement is much weaker than that of UK, which implicates more strict law enforcement policy is needed to improve our work-related safety.
No Longer Confidential: Estimating the Confidence of Individual Regression Predictions (2012)

Quantitative predictions in computational life sciences are often based on regression models. The advent of machine learning has led to highly accurate regression models that have gained widespread acceptance. While there are statistical methods available to estimate the global performance of regression models on a test or training dataset, it is often not clear how well this performance transfers to other datasets or how reliable an individual prediction is-a fact that often reduces a user's trust into a computational method. In analogy to the concept of an experimental error, we sketch how estimators for individual prediction errors can be used to provide confidence intervals for individual predictions. Two novel statistical methods, named CONFINE and CONFIVE, can estimate the reliability of an individual prediction based on the local properties of nearby training data. The methods can be applied equally to linear and non-linear regression methods with very little computational overhead. We compare our confidence estimators with other existing confidence and applicability domain estimators on two biologically relevant problems (MHC-peptide binding prediction and quantitative structure-activity relationship (QSAR)). Our results suggest that the proposed confidence estimators perform comparable to or better than previously proposed estimation methods. Given a sufficient amount of training data, the estimators exhibit error estimates of high quality. In addition, we observed that the quality of estimated confidence intervals is predictable. We discuss how confidence estimation is influenced by noise, the number of features, and the dataset size. Estimating the confidence in individual prediction in terms of error intervals represents an important step from plain, non-informative predictions towards transparent and interpretable predictions that will help to improve the acceptance of computational methods in the biological community.
Eminent Domain: Slum Clearance and Low-Cost Housing Program as Public Use (1936)

A New York statute set up a public corporation with power to investigate and study housing conditions in the city, and to plan and carry out projects for the clearance of slums and the providing of housing accommodations for persons of low income. The corporation sought to condemn certain property owned by the defendant, who resisted the proceeding on the ground that the taking was not for a public use and therefore violative of the Fourteenth Amendment and a similar provision in the state constitution. Held, that the taking was for a public benefit and that therefore the constitutional limitation of "public use" was not violated. New York City Housing Authority v. Muller, 270 N. Y. 333, 1 N. E. (2d) 153 (1936).
The physical nature of weak shock wave reflection (2005)

For weak shock waves and small wedge angles the application of three-shock (von Neumann) theory gives no physically realistic solutions and yet experiments clearly show a pattern of reflection of three shocks meeting at a triple point. This disagreement is referred to as the von Neumann paradox, and the reflection pattern as von Neumann reflection (vNR). Some recent numerical computations have indicated the existence of an expansion wave immediately behind the reflected wave as originally suggested by Guderley over fifty years ago. Furthermore, a recent solution of the inviscid transonic equations has indicated the possible existence of a very small, multi-wave structure immediately behind the three-shock confluence. A special shock tube has been constructed which allows Mach stem lengths to be obtained which are more than an order of magnitude larger than those obtainable in conventional shock tubes. Schlieren photographs do indeed show a structure consisting of an expansion wave followed by a small shock situated behind the confluence point, with some indication of smaller scale structures in some tests. This indicates that some of the earlier models of vNR, in the parameter space tested, are incorrect. The size of the region influenced by this small wave system is about 2% of the Mach stem length and it is therefore not surprising that it has not been detected before in conventional shock tube facilities.
Anti-cancer effects of Kochia scoparia fruit in human breast cancer cells (2014)

These results suggest that MEKS inhibits cell proliferation and induces apoptosis in breast cancer cells and that MEKS may have potential chemotherapeutic value for the treatment of human breast cancer.
Nursing and the 5As guideline to smoking cessation interventions. (2006)

Nurses, especially those in acute care settings, are either reluctant to or have little knowledge of how to provide brief, specific counselling for smoking cessation. This clinical update outlines how the nationally endorsed 5As model for smoking cessation may be implemented. (non-author abstract)
London Salerooms (1981)

London Salerooms Get access GRAHAM WELLS GRAHAM WELLS Search for other works by this author on: Oxford Academic Google Scholar Early Music, Volume 9, Issue 1, January 1981, Pages 85–88, https://doi.org/10.1093/earlyj/9.1.85 Published: 01 January 1981
Lactantiana (1960)

LACTANTIANA BY D. R. SHACKLETON BAILEY DIVINAE INSTITUTIONES I. 18. 17 rapient saevient et iniuriis insolenter inlatis humanae societatis foedus inrumpent, ut habere hostem possint, quem sceleratius deleant quam lacessierint. So Brandt. But Thilo's non is quite unnecessary. What Lactantius means is that the lovers of military glory will commit all sorts of crimes in order to provoke an enemy so that they may add the still greater crime of destroying him. I. 20. 40 facto itaque Capitolio supra ipsum Terminum foramen est in tecto relictum, ut quia non cesserat, libero caelo frueretur: quo ne ipsi quidem f ruebantur qui
Zone-doubled Fresnel zone plates for high-resolution hard X-ray full-field transmission microscopy (2012)

Full-field transmission X-ray microscopy is a unique non-destructive technique for three-dimensional imaging of specimens at the nanometer scale. Here, the use of zone-doubled Fresnel zone plates to achieve a spatial resolution better than 20 nm in the hard X-ray regime (8-10 keV) is reported. By obtaining a tomographic reconstruction of a Ni/YSZ solid-oxide fuel cell, the feasibility of performing three-dimensional imaging of scientifically relevant samples using such high-spatial-resolution Fresnel zone plates is demonstrated.
Rate of Change in Physical Fitness and Quality of Life and Depression Following Exercise Training in Patients With Congestive Heart Failure (2012)

Exercise training appears to improve peak oxygen consumption (VO(2) ) and quality of life (QOL) in heart failure patients, although disease etiology, patient demographics and medication may alter the rate of adaptation. The authors sought to identify rate of change from baseline in fitness, QOL, and depression following exercise training in a cohort of patients with congestive heart failure. Thirty male systolic heart failure patients (aged 63.8±8.3 years, baseline peak VO(2) 12.2±4.8 mL/kg/min, left ventricular ejection fraction 28.2±9.4%, New York Heart Association class II/II 22/8) undertook 52 weeks of exercise training, 16 weeks as an outpatient and a further 36 weeks of home exercise. Peak VO(2) and QOL was measured using the Minnesota Living With Heart Failure (MLWHF) questionnaire and depression using the Hare-Davis scale. The authors analyzed the rate of change in peak VO(2) and MLWHF after grouping patients according to clinical, demographic, and pharmacologic characteristics. Peak VO(2) measurements varied over time, with no effect of disease pathology or β-blocker on peak VO(2) . The rate of change in physical MLWHF score was significantly greater (improved) during 0 to 16 weeks in patients with dilated pathology, but was not significantly affected by β-blocker use or age. The exercise training venue and supervision, or lack thereof, is the major determinant of adaptation to the intervention in heart failure patients, although age, β-adrenergic medication, and heart failure etiology also explain some of the variation in adaptive responses observed.