gebhart/patrepeval huggingface dataset:
Bridging the I/O performance gap for big data workloads: A new NVDIMM-based approach (2016)

The long I/O latency posts significant challenges for many data-intensive applications, such as the emerging big data workloads. Recently, the NVDIMM (Non-Volatile Dual In-line Memory Module) technologies provide a promising solution to this problem. By employing non-volatile NAND flash memory as storage media and connecting them via DIMM (Dual Inline Memory Module) slots, the NVDIMM devices are exposed to memory bus so the access latencies due to going through I/O controllers can be significantly mitigated. However, placing NVDIMM on the memory bus introduces new challenges. For instance, by mixing I/O and memory traffic, NVDIMM can cause severe performance degradation on memory-intensive applications. Besides, there exists a speed mismatch between fast memory access and slow flash read/write operations. Moreover, garbage collection (GC) in NAND flash may cause up to several millisecond latency. This paper presents novel, enabling mechanisms that allow NVDIMM to more effectively bridge the I/O performance gap for big data workloads. To address the workload heterogeneity challenge, we develop a scheduling scheme in memory controller to minimize the interference between the native and the I/O-derived memory traffic by exploiting both data access criticality and resource utilization. For NVDIMM controller, several mechanisms are designed to better orchestrate traffic between the memory controller and NAND flash to alleviate the speed discrepancy issue. To mitigate the lengthy GC period, we propose a proactive GC scheme for the NVDIMM controller and flash controller to intelligently synchronize and transfer data involving in forthcoming GC operations. We present detailed evaluation and analysis to quantify how well our techniques fit with the NVDIMM design. Our experimental results show that overall the proposed techniques yield 10%~35% performance improvements over the state-of-the-art baseline schemes.
A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice. (1992)

We have previously reported that T cells bearing T cell receptors (TCRs) of gamma/delta type appear at a relatively early stage of primary infection with Listeria monocytogenes in mice. To characterize the early-appearing gamma/delta T cells during listeriosis, we analyzed the specificity and cytokine production of the gamma/delta T cells in the peritoneal cavity in mice inoculated intraperitoneally with a sublethal dose of L. monocytogenes. The early-appearing gamma/delta T cells, most of which were of CD4-CD8- phenotype, proliferated and secreted IFN-gamma and macrophage chemotactic factor in response to purified protein derivative from Mycobacterium tuberculosis, or recombinant 65-kD heat-shock protein derived from M. bovis but not to heat-killed Listeria. To further elucidate the potential role of the gamma/delta T cells in the host-defense mechanism against primary infection with Listeria, we examined the effects of in vivo administration of monoclonal antibodies (mAbs) against TCR-gamma/delta or TCR-alpha/beta on the bacterial eradication in mice infected with Listeria. Most of alpha/beta T cells or gamma/delta T cells were depleted in the peripheral lymphoid organs at least for 12 d after an intraperitoneal injection of 200 micrograms TCR-alpha/beta mAb or 200 micrograms TCR-gamma/delta mAb, respectively. An exaggerated bacterial multiplication was evident at the early stage of listerial infection in the gamma/delta T cells-depleted mice, whereas the alpha/beta T cell-depleted mice exhibited much the same resistance level as the control mice at this stage although the resistance was severely impaired at the late stage after listerial infection.(ABSTRACT TRUNCATED AT 250 WORDS)
OLAP Query Processing in Grids ∗ (2008)

Abstract. OLAP query processing is critical for enterprise grids. Capitalizing on our experience with the ParGRES database cluster, we propose a middleware solution, GParGRES, which exploits database replication and inter- and intra-query parallelism to efficiently support OLAP queries in a grid. GParGRES has been partially implemented as database grid services on Grid5000. We give preliminary experimental results obtained with two clusters of Grid5000 using queries of the TPC-H Benchmark. The results show linear or almost linear speedup in query execution, as more nodes are added in all tested configurations. 1.
Celiac Disease Association with CD8+ T Cell Responses: Identification of a Novel Gliadin-Derived HLA-A2-Restricted Epitope (2003)

One of the diagnostic hallmarks of the histological lesions associated with celiac disease is the extensive infiltration of the small intestinal epithelium by CD8(+) T cells of unknown Ag specificity. In this study, we report recognition of the gliadin-derived peptide (A-gliadin 123-132) by CD8(+) T lymphocytes from celiac patients. A-gliadin 123-132-specific IFN-gamma production and cytotoxic activity were detected in PBMCs derived from patients on gluten-free diet, but not from either celiac patients on gluten-containing diet or healthy controls. In contrast, A-gliadin 123-132-specific cells were isolated from small intestine biopsies of patients on either gluten-free or gluten-containing diets. Short-term T cell lines derived from the small intestinal mucosa and specific for the 123-132 epitope recognized human APC pulsed with either whole recombinant alpha-gliadin or a partial pepsin-trypsin gliadin digest. Finally, we speculate on a possible mechanism leading to processing and presentation of class I-restricted gliadin-derived epitopes in celiac disease patients.
Functionalization of saturated hydrocarbons. Part 4. The Gif system for selective oxidation using molecular oxygen (1986)

Various systems for the selective oxidation of saturated hydrocarbons have been developed. These are based on the idea of an iron catalyst which is reduced by electron transfer and oxidized by molecular oxygen simultaneously in the presence of a source of protons. Four modifications of this system (the Gif system) have been devised of which the best (Gif IV) consists of an iron catalyst with metallic zinc as the reductant, acetic acid as the proton source and pyridine as the solvent. At room temperature, using oxygen or air saturated hydrocarbons are oxidized selectively to ketones in isolated yields superior to those reported for comparable model systems.
ChemInform Abstract: Industrial Synthesis of the Key Precursor in the Synthesis of the Antiinfluenza Drug Oseltamivir Phosphate (Ro 64‐0796/002, GS‐4104‐02): Ethyl (3R,4S,5S)‐4,5‐Epoxy‐3‐(1‐ethyl‐propoxy)‐cyclohex‐1‐ene‐1‐carboxylate. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In-vitro matured metaphase-I oocytes have a lower fertilization rate but similar embryo quality as mature metaphase-II oocytes after intracytoplasmic sperm injection (1999)

About 4% of all the oocytes denuded prior to intracytoplasmic sperm injection (ICSI) are in metaphase-I (MI). Frequently, these oocytes achieve meiosis after a few hours of in-vitro culture and are available for ICSI on the day of oocyte retrieval. In this retrospective study, the aim was to evaluate the fertilization rate and the developmental capacity of these in-vitro matured MI oocytes. After controlled ovarian stimulation using human menopausal gonadotrophin (HMG) and human chorionic gonadotrophin (HCG) in 896 ICSI cycles, 1210 MI-to-MII-matured oocytes were injected approximately 4 h after in-vitro culture and 8803 MII oocytes were injected immediately, or later, after denudation. The fertilization rate of in-vitro matured oocytes was significantly lower than that of mature MII oocytes (52.7 and 70.8% respectively, P < 0.00l). Embryo quality was only slightly different as regards the numbers of good quality embryos: 47.4% good quality embryos were obtained in the in-vitro matured oocyte group, whereas 53.2% good quality embryos were obtained in the MII oocyte group (P < 0.05). The same proportions of excellent (5.7 and 7.0%, NS) and fair quality (17.6 and 15.3%, NS) embryos were obtained for in-vitro matured and mature oocytes respectively. Embryos derived from in-vitro matured oocytes were transferred only if they were of better quality or if there were not enough mature oocyte derived embryos available. Fifteen transfers involved only embryos derived from in-vitro matured oocytes: 11 single embryo transfers and four transfers of two embryos, resulting in one singleton pregnancy and the birth of a healthy baby. It may be concluded that in cycles with few MII oocytes it might be worthwhile to inject in-vitro matured MI oocytes in order to increase the number of embryos available for transfer.
Acute and Recurrent Infection with Herpes Simplex Virus in the Mouse: a Model for Studying Latency and Recurrent Disease (1975)

Nineteen recent isolated and three laboratory strains of herpes simplex virus types 1 and 2 were tested for their ability to produce clinical signs in mice following intradermal inoculation in the ear. All viruses produced erythema at the inoculation site; this was the most sensitive clinical sign of infection. Virus multiplication in the ear tissue was similar for both types 1 and 2 up to the fifth day after inoculation but type 2 viruses persisted for longer. Latent infection was demonstrated in cervical dorsal root ganglia. Type 1 viruses required a much higher dose than type 2 to produce neurological signs and death after intradermal inoculation but the difference was less after intracerebral inoculation. Erythema of the inoculated ear recurred sporadically during several months observation in about half the mice that survived intradermal infection with a selected type 1 isolate. The presence of virus in the ear tissue during such recurrences was confirmed by electron microscopy and isolation of infectious virus. The system of ear infection in the mouse is presented as a new model for studying neurovirulence, and latent and recurrent infection with herpes simplex virus.
Fuzzy associative memory optimization using genetic algorithms (1994)

Recently genetic algorithms (GAs) have been used to search high performance fuzzy membership functions in increasing number of control applications. They differ primarily in the ways the search space is encoded and the objective function is targeted. In this paper, we focus on the effectiveness of GAs to optimize the fuzzification step in the fuzzy rule generation method of Wang-Mendel (1991). The method generates a fuzzy rule base from a set of numerical training data organizing it into a fuzzy associative-memory (FAM) bank, and produces a mapping from input space to output space based on the FAM bank using a defuzzifying procedure. The fuzzification step in the method partitions both the input and output spaces into fuzzy regions. Results show that by optimizing the membership functions via GAs, the total error between desired output data and defuzzified output data can be reduced by as much as 50%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Steroid Hormone Transforming Aldo‐Keto Reductases and Cancer (2009)

Prostate and breast cancer are hormone-dependent malignancies of the aging male and female and require the local production of androgens and estrogens to stimulate cell proliferation. Aldo-keto reductases (AKR) play key roles in this process. In the prostate, AKR1C3 (type 5 17beta-HSD) reduces Delta(4)-androstene-3,17-dione to yield testosterone while AKR1C2 (type 3 3alpha-HSD) eliminates 5alpha-dihydrotestosterone (5alpha-DHT), and AKR1C1 forms 3beta-androstanediol (a ligand for ERbeta). In the breast, AKR1C3 forms testosterone, which is converted to 17beta-estradiol by aromatase or reduces estrone to 17beta-estradiol directly. AKR1C3 also acts as a prostaglandin (PG) F synthase and forms PGF(2alpha) and 11beta-PGF(2alpha), which stimulate the FP receptor and prevent the activation of PPARgamma by PGJ(2) ligands. This proproliferative signaling may stimulate the growth of hormone-dependent and -independent prostate and breast cancer.
Interactive contrast enhancement using an electronic hardware system (1984)

An electronic system for the enhancement of video image contrast in real time is described and examples of its application are shown. The system achieves high speed and flexibility through the use of microprocessor-controlled digital hardware, rendering it useful as an interactive tool for image processing at relatively low cost. Several stretching techniques are demonstrated, including an interactive method whereby an elaborate contrast transfer function may be specified manually.
Bias dependence of magnetic exchange interactions: Application to interlayer exchange coupling in spin valves (2009)

We study how a bias voltage changes magnetic exchange interactions. We derive a general expression for magnetic exchange interactions for systems coupled to reservoirs under a bias potential and apply it to spin valves. We find that for metallic systems, the interlayer exchange coupling shows a weak oscillatory dependence on the bias potential. For tunneling systems, we find a quadratic dependence on the bias potential and derive an approximate expression for this bias dependence for a toy model. We give general conditions for when the interlayer exchange coupling is a quadratic function of bias potential.
Zero Energy Buildings: A Critical Look at the Definition (2006)

A net zero-energy building (ZEB) is a residential or commercial building with greatly reduced energy needs through efficiency gains such that the balance of energy needs can be supplied with renewable technologies. Despite the excitement over the phrase “zero energy,” we lack a common definition, or even a common understanding, of what it means. In this paper, we use a sample of current generation low-energy buildings to explore the concept of zero energy: what it means, why a clear and measurable definition is needed, and how we have progressed toward the ZEB goal. The way the zero energy goal is defined affects the choices designers make to achieve this goal and whether they can claim success. The ZEB definition can emphasize demand-side or supply strategies and whether fuel switching and conversion accounting are appropriate to meet a ZEB goal. Four well-documented definitions—net-zero site energy, net-zero source energy, net-zero energy costs, and net-zero energy emissions—are studied; pluses and minuses of each are discussed. These definitions are applied to a set of low-energy buildings for which extensive energy data are available. This study shows the design impacts of the definition used for ZEB and the large difference between definitions. It also looks at sample utility rate structures and their impact on the zero energy scenarios.
DEVELOPMENT OF A NOVEL STEERABLE BOUGIE (2016)

This paper describes the development of a new airway device that will improve the speed and safety of endotracheal intubation in anaesthesia and critical care. Case of need, design specification and fabrication of the steerable bougie mechanism is discussed.
Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution. (1996)

The yeast Prp9p, Prp11p, Prp21p proteins form a multimolecular complex identified as the SF3a splicing factor in higher eukaryotes. This factor is required for the assembly of the prespliceosome. Prp21p interacts with both Prp9p and Prp11p, but the molecular basis of these interactions is unknown. Prp21p, its human homologue, and the so-called SWAP proteins share a tandemly repeated motif, the surp module. Given the evolutionary conservation and the role of SWAP proteins as splicing regulators, it has been proposed that surp motifs are essential for interactions between Prp21p and other splicing factors. In order to characterize functional domains of Prp21p and to identify potential additional functions of this protein, we isolated a series of heat-sensitive prp21 mutants. Our results indicate that prp21 heat-sensitive mutations are associated with defects in the interaction with Prp9p, but not with Prp11p. Interestingly, most heat-sensitive point mutants associate a strong splicing defect with a pre-mRNA nuclear export phenotype, as does the prp9-1 heat-sensitive mutant. Deletion analyses led to the definition of domains required for viability. These domains are responsible for the interaction with Prp9p and Prp11p and are conserved through evolution. They do not include the most conserved surp1 module, suggesting that the conservation of this motif in two families of proteins may reflect a still unknown function dispensable in yeast under standard conditions.
Air Damping Analysis of a Micro-Coriolis Mass Flow Sensor (2022)

A micro-Coriolis mass flow sensor is a resonating device that measures small mass flows of fluid. A large vibration amplitude is desired as the Coriolis forces due to mass flow and, accordingly, the signal-to-noise ratio, are directly proportional to the vibration amplitude. Therefore, it is important to maximize the quality factor Q so that a large vibration amplitude can be achieved without requiring high actuation voltages and high power consumption. This paper presents an investigation of the Q factor of different devices in different resonant modes. Q factors were measured both at atmospheric pressure and in vacuum. The measurement results are compared with theoretical predictions. In the atmospheric environment, the Q factor increases when the resonance frequency increases. When reducing the pressure from 1 bar to 0.1 bar, the Q factor almost doubles. At even lower pressures, the Q factor is inversely proportional to the pressure until intrinsic effects start to dominate, resulting in a maximum Q factor of approximately 7200.
High-peak-power, pulsed CO_2 laser light delivery by hollow glass waveguides (1997)

Flexible hollow glass waveguides with internal metallic and dielectric coatings have been used to deliver high-peak-power transversely excited atmosphere CO(2) laser energy. The straight guide loss is as low as 0.17 dB/m for 1000-mum-bore guides and 0.46 dB/m for 530-mum-bore guides propagating the HE(11) mode. The loss increases to 0.93 and 1.36 dB/m, respectively, when guides are bent to a radius of 0.25 m. The hollow glass waveguides have been used to deliver pulsed CO(2) laser energy successfully with a peak power of 0.7 MW and an energy of 350 mJ per pulse with a gas purge through the hollow core. The delivered average power is as high as 27 W. It is concluded that these waveguides are promising candidates for pulsed CO(2) laser delivery in medical and surgical applications.
Grip forces and load forces in handovers (2012)

In this study, we investigate and characterize haptic interaction in human-to-human handovers and identify key features that facilitate safe and efficient object transfer. Eighteen participants worked in pairs and transferred weighted objects to each other while we measured their grip forces and load forces. Our data show that during object transfer, both the giver and receiver employ a similar strategy for controlling their grip forces in response to changes in load forces. In addition, an implicit social contract appears to exist in which the giver is responsible for ensuring object safety in the handover and the receiver is responsible for maintaining the efficiency of the handover. Compared with prior studies, our analysis of experimental data show that there are important differences between the strategies used by humans for both picking up/placing objects on table and that used for handing over objects, indicating the need for specific robot handover strategies as well. The results of this study will be used to develop a controller for enabling robots to perform object handovers with humans safely, efficiently, and intuitively.
Automatic generation of model based tests for a class of security properties (2007)

This paper is a contribution to the problem of getting confident in the fact that an implementation correctly meets a security policy assigned to it. To do so, we compute tests that exercise security properties issued from the security policy. We proceed by model based testing. Classically, we use a functional model that formalizes the functional specification. But we also use a second model, in the shape of security properties, that formalize a part of the security policy. Tests are computed from the security properties, with the formal functional model as an oracle.
Support-Enhanced Selective Aerobic Alcohol Oxidation over Pd/Mesoporous Silicas (2011)

The influence of silica mesostructure upon the Pd-catalyzed selective oxidation of allylic alcohols has been investigated for amorphous and surfactant-templated SBA-15, SBA-16, and KIT-6 silicas. Significant rate enhancements can be achieved via mesopore introduction, most notably through the use of interconnected porous silica frameworks, reflecting both improved mass transport and increased palladium dispersion; catalytic activity decreases in the order Pd/KIT-6 ≈ Pd/SBA-16 > Pd/SBA-15 > Pd/SiO2. Evidence is presented that highly dispersed palladium oxide nanoparticles, not zerovalent palladium, are the catalytically active species.
Catalytic Cracking with FCCT Loaded with Tin Metal Traps. Adsorption Constants for Gas Oil, Gasoline and Light Gases (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic Cracking with FCCT Loaded with Tin Metal Traps. Adsorption Constants for Gas Oil, Gasoline and Light GasesHany Farag, Alberto Blasetti, and Hugo de LasaCite this: Ind. Eng. Chem. Res. 1994, 33, 12, 3131–3140Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/ie00036a031https://doi.org/10.1021/ie00036a031research-articleACS PublicationsRequest reuse permissionsArticle Views169Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts