gebhart/patrepeval huggingface dataset:
A machine learning approach to acronym generation (2005)

This paper presents a machine learning approach to acronym generation. We formalize the generation process as a sequence labeling problem on the letters in the definition (expanded form) so that a variety of Markov modeling approaches can be applied to this task. To construct the data for training and testing, we extracted acronym-definition pairs from MEDLINE abstracts and manually annotated each pair with positional information about the letters in the acronym. We have built an MEMM-based tagger using this training data set and evaluated the performance of acronym generation. Experimental results show that our machine learning method gives significantly better performance than that achieved by the standard heuristic rule for acronym generation and enables us to obtain multiple candidate acronyms together with their likelihoods represented in probability values.
Effects of Meloxicam Compared to Acetylsalicylic Acid in Human Articular Chondrocytes (1997)

Meloxicam is a new nonsteroidal anti-inflammatory drug (NSAID) derived from enolic acid, which has displayed potent anti-inflammatory properties in animal studies combined with low gastrointestinal toxicity. Other NSAIDs have been shown, in vitro, to have a variety of effects on cartilage repair processes in diseased articular cartilage. The aim of this study was to ascertain the effects of meloxicam on some of these processes using in vitro models. Acetylsalicylic acid, a NSAID whose characteristics have been previously elucidated in the models, was used as an active comparator. The effects of meloxicam were different from those of acetylsalicylic acid on chondrocyte clusters. At pharmacologically active concentrations, meloxicam was a potent inhibitor of prostaglandin-E2 production. However, all chondroformative processes were unaffected by meloxicam as indicated by a lack of effect on DNA synthesis and on type-II collagen and proteoglycan levels in chondrocyte culture medium and clusters, while acetylsalicylic acid decreased proteoglycan production and cell proliferation. Consequently, these in vitro findings suggest that meloxicam does not adversely affect the reparative processes active within the cartilage matrix of a diseased joint. This study represents a sound basis for future studies to establish the effects of meloxicam on osteoarthritis disease progression.
Participation of pterins in the control of lymphocyte stimulation and lymphoblast proliferation. (1983)

Biopterin accumulation had been demonstrated as the result of normal and, especially, of malignant hemopoietic cell proliferation (Ziegler, I. et al. Blut, 44: 231-240, and 261-270, 1982). Among 13 major intermediates of pterin metabolism and two lumazines, xanthopterin (but not dihydroxanthopterin) was found to inhibit cell proliferation (half-maximum inhibition at 1.8 X 10(-5) M) during concanavalin A-induced lymphocyte activation in pre-stimulated lymphocytes and in a lymphoid cell line grown in continuous culture (LS-2). LS-2 cells exposed to maximum inhibitor concentrations largely maintained the initial thymidine incorporation rate for about 40 hr but failed to enter logarithmic growth. Isoxanthopterin inhibition was found only in serum-free medium, since it is trapped by the alpha-acid glycoprotein present in the serum. The reduced biopterin derivatives, sepiapterin, dihydrobiopterin, and tetrahydrobiopterin, are costimulators during concanavalin A-induced lymphocyte activation. Their costimulatory effect follows an optimum curve and peaks at 1.5 to 3 X 10(-5) M. It is highest at the suboptimal and supraoptimal concanavalin A concentration. The D-erythro isomer dihydroneopterin was inactive. The results indicate that the anabolic-reduced biopterin derivatives are not simply lymphocytic products, but, in combination with the catabolites xanthopterin and isoxanthopterin, they also participate in the regulation of lymphocyte activation. Hence, they fulfill the criteria for lymphokines.
Practical Camera Auto Calibration using Semidefinite Programming (2007)

We describe a novel approach to the camera auto calibration problem. The uncalibrated camera is first moved in a static scene and feature points are matched across frames to obtain the feature tracks. Mismatches in these tracks are identified by computing the fundamental matrices between adjacent frames. The inlier feature tracks are then used to obtain a projective structure and motion of the camera using iterative perspective factorization scheme. The novelty of our approach lies in the application of semidefinite programming for recovering the camera focal lengths and the principal point. Semidefinite programming was used in our earlier work [1] to recover focal lengths under the assumption of known principal points. In this paper, we relax the constraint of known principal point and do an exhaustive search for the principal points. Moreover, we describe an end-to-end system for auto calibration and present experimental results to evaluate our approach.
Feedback connection for deep neural network-based acoustic modeling (2017)

The use of auxiliary features is an effective way to improve the performance of deep neural network (DNN)-based acoustic models. Most approaches use auxiliary features that represent the speaker or the environment. These auxiliary features are usually computed independently of the acoustic model. This paper investigates a types of auxiliary features obtained from the output of a hidden layer that feeds back to the input layer of the network. Since the auxiliary features are extracted from the hidden layer of the network no external information is required such as the speaker or the environment. Experimentally, by forcing the extraction of the auxiliary features from the same networks, we can further improve the performance of the overall network and reduce the total number of parameters used. We tested this approach with different deep neural network architectures including: deep neural networks, convolutional neural networks and unfolded recurrent convolutional networks. We confirmed the effectiveness of this approach on the CHiME3 dataset.
Adipose Tissue Collagen VI in Obesity (2009)

These results are consistent with basic science data, suggesting that COL6A3 might contribute to adipose tissue inflammation.
Repair of acetone‐ and sodium lauryl sulphate‐damaged human skin barrier function using topically applied emulsions containing barrier lipids (2002)

The investigative methods used in this study show that ceramides combined with other skin lipids can improve barrier repair after damage.
BGP-reflection functors and cluster combinatorics (2005)

We define Bernstein-Gelfand-Ponomarev reflection functors in the cluster categories of hereditary algebras. They are triangle equivalences which provide a natural quiver realization of the "truncated simple reflections" on the set of almost positive roots $Φ_{\ge -1}$ associated to a finite dimensional semisimple Lie algebra. Combining with the tilting theory in cluster categories developed in [4], we give a unified interpretation via quiver representations for the generalized associahedra associated to the root systems of all Dynkin types (a simply-laced or non-simply-laced). This confirms the conjecture 9.1 in [4] in all Dynkin types.
Mechanisms of Resistance to Quinupristin-Dalfopristin among Isolates of <i>Enterococcus faecium</i> from Animals, Raw Meat, and Hospital Patients in Western Europe (2000)

Twenty-eight quinupristin-dalfopristin-resistant isolates of Enterococcus faecium from hospital patients and nonhuman sources in European countries were studied. High-level resistance (MICs, >/=32 microg/ml) was associated with the presence of vat(E) (satG) (14 isolates ¿50%) or vat(D) (satA) (6 isolates ¿21%). These genes were not detected in eight (29%) isolates with lower levels of quinupristin-dalfopristin resistance (MICs, 4 to 16 microg/ml). This suggests the presence of further mechanisms of resistance to quinupristin-dalfopristin in E. faecium.
A specific, high-affinity binding site for the hepta-beta-glucoside elicitor exists in soybean membranes. (1991)

The presence of a specific binding site for a hepta-beta-glucoside elicitor of phytoalexin accumulation has been demonstrated in soybean microsomal membranes. A tyramine conjugate of the elicitor-active hepta-beta-glucoside was prepared and radiolabeled with 125I. The labeled hepta-beta-glucoside-tyramine conjugate was used as a ligand in binding assays with a total membrane fraction prepared from soybean roots. Binding of the radiolabeled hepta-beta-glucoside elicitor was saturable, reversible, and with an affinity (apparent Kd = 7.5 x 10(-10) M) comparable with the concentration of hepta-beta-glucoside required for biological activity. A single class of hepta-beta-glucoside binding sites was found. The binding site was inactivated by proteolysis and by heat treatment, suggesting that the binding site is a protein or glycoprotein. Competitive inhibition of binding of the radiolabeled hepta-beta-glucoside elicitor by a number of structurally related oligoglucosides demonstrated a direct correlation between the binding affinities and the elicitor activities of these oligoglucosides. Thus, the hepta-beta-glucoside-binding protein fulfills criteria expected of a bona fide receptor for the elicitor-active oligosaccharin.
Real-time speech enhancement system using envelope expansion technique (1989)

A real-time system for the enhancement of speech signals degraded by additive broadband noise is described. The enhancement process employed is a multiband envelope expansion technique derived from a recent speech dereverberation method and the system is implemented on a Texas Instruments TMS32O-C25 processor.
The use of bacteriophage T4 as a set of molecular weight and isoelectric point markers for two‐dimensional electrophoresis (1981)

Abstract We have studied the use of bacteriophage T4 coat proteins as a complete set of molecular weight and isoelectric point markers for two‐dimensional electrophoresis. We present data which support the feasibility of this approach. The potential utility and advantages of this concept are discussed.
Efficacy of Bovine Transfer Factor to Protect Neonatal Calves against Experimentally Induced Clinical Cryptosporidiosis (1987)

R. Fayer, P. H. Klesius, C. Andrews, Efficacy of Bovine Transfer Factor to Protect Neonatal Calves against Experimentally Induced Clinical Cryptosporidiosis, The Journal of Parasitology, Vol. 73, No. 5 (Oct., 1987), pp. 1061-1062
Plasma Enhanced Chemical Vapor Deposition on Powders in a Low Temperature Plasma Fluidized Bed (1998)

Low temperature plasmas, including plasma enhanced chemical vapor deposition (PECVD), play a special role in the deposition of thin films; however, until now no satisfactory process for coating temperature sensitive powders and granules existed. The authors present the coating of a significant amount of particles in a fluidized bed under low temperature plasma conditions using PECVD.
Components for multiple wavelength systems in polymer optoboard technology (2002)

Multiple wavelength systems obviously require more optical components than single wavelength systems. Not only the necessary multiplexing and de-multiplexing functions add component complexity, but more importantly, the addition of extra space switching components enables the implementation of sophisticated routing mechanisms, offering superb operational network flexibility. In order to arrive at a reliable and cost effective solution for such wavelength routing, integration of several functionality's in a single packaged component will become a necessity. At least two technologies have the potential to provide such solutions: III-V semiconductors and polymer optoboards. The latter option will be described below, covering wavelength multiplexing and space switching based on polymer waveguides. The combination of multiplexers and switches on a single substrate will be a major improvement in system reliability and performance. Both functions have individually been demonstrated with good performance.
A partially switched-opamp technique for high-speed low-power pipelined analog-to-digital converters (2006)

This paper presents a partially switched-opamp technique for a high-speed, low-power pipelined analog-to-digital converter (ADC). Unlike a conventional switched-opamp technique, only the second stage of a two-stage opamp is switched with the enhanced power efficiency and the drawbacks of an opamp sharing technique and a conventional switched-opamp technique are addressed. The prototype of 8-bit 200-MS/s pipelined ADC is implemented in a 0.18-/spl mu/m CMOS process technology. This converter achieves 55.8-dB spurious free dynamic range, 47.3-dB signal-to-noise-plus-distortion ratio, 7.68 effective number of bits for a 90-MHz input at full sampling rate, and consumes 30-mW from a 1.8-V supply. The active area of the ADC is 0.15 mm/sup 2/.
Event-related potentials and cognition: A critique of the context updating hypothesis and an alternative interpretation of P3 (1988)

Abstract P3 is the most prominent of the electrical potentials of the human electroencephalogram that are sensitive to psychological variables. According to the most influential current hypothesis about its psychological significance [E. Donchin's], the “context updating” hypothesis, P3 reflects the updating of working memory. This hypothesis cannot account for relevant portions of the available evidence and it entails some basic contradictions. A more general formulation of this hypothesis is that P3 reflects the updating of expectancies. This version implies that P3-evoking stimuli are initially unexpected but later become expected. This contradiction cannot be resolved within this formulation. The alternative “context closure” hypothesis retains the concept of “strategic information processing” emphasized by the context updating hypothesis. P3s are evoked by events that are awaited when subjects deal with repetitive, highly structured tasks; P3s arise from subjects' combining successive stimuli into larger units. The tasks in which P3s are elicited can accordingly be classified in terms of their respective formal sequences of stimuli. P3 may be a physiological indicator of excess activation being released from perceptual control areas.
Intracellular Signaling of gp34, the OX40 Ligand: Induction of c- <i>jun</i> and c- <i>fos</i> mRNA Expression Through gp34 upon Binding of Its Receptor, OX40 (1999)

We investigated the intracellular signaling events of OX40 ligand (gp34), a member of the TNF family. To elucidate the intracellular signaling via gp34, we prepared a model system in which a human gp34-transfected mouse epithelial cell line was stimulated with a recombinant soluble form of OX40. We demonstrated that OX40 binding resulted in increase in c-jun and c-fos mRNA levels in this transfectant by Northern blot analysis, which was blocked by the pretreatment with anti-gp34 Ab. The studies with various gp34 deletion mutants showed that the cytoplasmic portion including the amino acid sequence 16-21 (RPRFER) was required for the induction of c-jun and c-fos mRNA expression. Furthermore, OX40 binding induced c-jun mRNA expression also in HUVECs, which in our previous study have been shown to express gp34 and interact with activated T cells through the OX40/gp34 pathway. On the other hand, c-fos mRNA was detectable neither in unstimulated HUVECs nor in gp34-stimulated HUVECs. These results indicate that the OX40/gp34 system generates two-way signals and may elicit biological effects on vascular endothelial cells.
Collagen cross-linking. Isolation of cross-linked peptides from collagen of chicken bone (1973)

Cross-linked peptides were isolated from chicken bone collagen that had been digested with CNBr or with bacterial collagenase. Analyses of (3)H radioactivity in disc electrophoretic profiles of the CNBr peptides from bone collagens that had been treated with NaB(3)H indicated that a major site of intermolecular cross-linking in chicken bone collagen is located between the carboxy-terminal region of an alpha1 chain and a small CNBr peptide, probably situated near the amino-terminus of an alpha1 or alpha2 chain in an adjacent collagen molecule. A small amount of this cross-linked CNBr peptide was isolated from a CNBr digest of chicken bone collagen by column chromatography. Amino acid analysis showed that the CNBr peptide, alpha1CB6B, the carboxy-terminal peptide of the alpha1 chain, was the major CNBr peptide in the preparation, and the reduced cross-linking components were identified as hydroxylysinohydroxynorleucine (HylOHNle), with a smaller amount of hydroxylysinonorleucine (HylNle). However, the composition and the low recovery of the cross-linking amino acids suggested that the preparation was a mixture of CNBr peptides alpha1CB6B and alpha1CB6B cross-linked to a small CNBr peptide whose identity could not be determined. A small cross-linked peptide was isolated from chicken bone collagen that had been reduced with NaB(3)H(4) and digested with bacterial collagenase. This peptide was the major cross-linked peptide in the digest and contained a stoicheiometric amount of the reduced cross-linking compounds. A peptide which had the same amino acid composition, but contained the cross-linking compounds in their reducible forms, was isolated from a collagenase digest of chicken bone collagen that had not been treated with NaBH(4). The absence of the reduced cross-links from this peptide indicates that, at least for the cross-linking site from which the peptide derives, natural reduction is not a significant pathway for biosynthesis of stable cross-links. However, most of the reducible cross-linking component in the peptide appeared to stabilize in the bone collagen by rearrangement from aldimine to ketoamine form.
Neural induction promotes large-scale chromatin reorganisation of the<i>Mash1</i>locus (2005)

Determining how genes are epigenetically regulated to ensure their correct spatial and temporal expression during development is key to our understanding of cell lineage commitment. Here we examined epigenetic changes at an important proneural regulator gene Mash1 (Ascl1), as embryonic stem (ES) cells commit to the neural lineage. In ES cells where the Mash1 gene is transcriptionally repressed, the locus replicated late in S phase and was preferentially positioned at the nuclear periphery with other late-replicating genes (Neurod, Sprr2a). This peripheral location was coupled with low levels of histone H3K9 acetylation at the Mash1 promoter and enhanced H3K27 methylation but surprisingly location was not affected by removal of the Ezh2/Eed HMTase complex or several other chromatin-silencing candidates (G9a, SuV39h-1, Dnmt-1, Dnmt-3a and Dnmt-3b). Upon neural induction however, Mash1 transcription was upregulated (>100-fold), switched its time of replication from late to early in S phase and relocated towards the interior of the nucleus. This spatial repositioning was selective for neural commitment because Mash1 was peripheral in ES-derived mesoderm and other non-neural cell types. A bidirectional analysis of replication timing across a 2 Mb region flanking the Mash1 locus showed that chromatin changes were focused at Mash1. These results suggest that Mash1 is regulated by changes in chromatin structure and location and implicate the nuclear periphery as an important environment for maintaining the undifferentiated state of ES cells.
SOME FERTILE HYBRIDS OF BUNCH AND MUSCADINE GRAPES (1962)

Journal Article SOME FERTILE HYBRIDS OF BUNCH AND MUSCADINE GRAPES Get access ROBERT T. DUNSTAN ROBERT T. DUNSTAN Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 53, Issue 6, November 1962, Pages 299–303, https://doi.org/10.1093/oxfordjournals.jhered.a107200 Published: 01 November 1962
An Expert System for Electric Operating Note Genesis and Network Computer Supported Cooperative Work (2002)

With an aim at the demands by the remote control management of the automation of power grid operation in power plant and the unmaned transformer station,this paper presents an expert system for the computer operating note intelligent processing as well as a decision support system(DSS) with modern network remote computer supported cooperative work(CSCW).This system has such functions as machine learning,knowledge transaction or processing and validation aided with graphics;and its database designing can meet with the auto submission of multi point operation data connection and upkeep configures in different times. This system has also a friendly interface between persons and machines and agile message driving mechanism,convenience for maintenance and operation and features and effects of agile message driving mechanism flexibility via the network communication and the remote analogous display of the workaround state.
Mechanisms of Nanoparticle-Mediated siRNA Transfection by Melittin-Derived Peptides (2013)

Traditional peptide-mediated siRNA transfection via peptide transduction domains exhibits limited cytoplasmic delivery of siRNA due to endosomal entrapment. This work overcomes these limitations with the use of membrane-destabilizing peptides derived from melittin for the knockdown of NFkB signaling in a model of adult T-cell leukemia/lymphoma. While the mechanism of siRNA delivery into the cytoplasmic compartment by peptide transduction domains has not been well studied, our analysis of melittin derivatives indicates that concurrent nanocomplex disassembly and peptide-mediated endosomolysis are crucial to siRNA transfection. Importantly, in the case of the most active derivative, p5RHH, this process is initiated by acidic pH, indicating that endosomal acidification after macropinocytosis can trigger siRNA release into the cytoplasm. These data provide general principles regarding nanocomplex response to endocytosis, which may guide the development of peptide/siRNA nanocomplex-based transfection.
Advantages of using thin sodium iodide detectors for thyroid monitoring of personnel working with 125I. (1980)

Measurements of neck count-rates for personnel who regularly iodinated proteins with 125I showed that, generally, count rates were higher after iodination than before. The major pathway for the intake of 125I during iodination was through skin that was exposed to the free-iodine atmosphere of the fume hood. Neck count-rates were measured in 34 other subjects who were working with 125I. The rates for 25 of them were significantly greater than for a control group of 36 subjects. Significant activities were also detected in seven of nine subjects who had never worked directly with 125I but who were located within areas where it was used extensively. To minimize thyroid burdens of 125I, it is essential that neck count-rates be measured routinely, in order to monitor the safety of procedures involving the use of 125I.
Multiresolution Bilateral Filtering for Image Denoising (2008)

The bilateral filter is a nonlinear filter that does spatial averaging without smoothing edges; it has shown to be an effective image denoising technique. An important issue with the application of the bilateral filter is the selection of the filter parameters, which affect the results significantly. There are two main contributions of this paper. The first contribution is an empirical study of the optimal bilateral filter parameter selection in image denoising applications. The second contribution is an extension of the bilateral filter: multiresolution bilateral filter, where bilateral filtering is applied to the approximation (low-frequency) subbands of a signal decomposed using a wavelet filter bank. The multiresolution bilateral filter is combined with wavelet thresholding to form a new image denoising framework, which turns out to be very effective in eliminating noise in real noisy images. Experimental results with both simulated and real data are provided.