gebhart/patrepeval huggingface dataset:
Antioxidant Effects of Polyphenols in Chocolate on Low-Density Lipoprotein both In Vitro and Ex Vivo. (2000)

Cacao is rich in polyphenols such as (-)-epicatechin, and a colored component of cacao (cacao-red) is polyphenol, which is an antioxidant. These properties stimulated an investigation of the effects of cacao liquor polyphenols (CLP) on low-density lipoprotein (LDL) oxidation. The 2.2 '-azobis(4-methoxy-2,4-dimethylvaleronitrile) (AMVN-CH2O)-induced oxidizability of LDL was assessed by monitoring the absorbance at 234 nm. In vitro. 0.1-0.5 mg/dL CLP prolonged the oxidation lag time of LDL in a dose-dependent manner. Compared with the controls, it was prolonged 1.7-fold in the presence of 0.1 mg/dL CLP, 2.9-fold at 0.2 mg/dL, 3.8-fold at 0.3 mg/dL, 5.4-fold at 0.4 mg/dL, and 6.4-fold at 0.5 mg/dL. Furthermore, we enlisted 13 male volunteers to consume 35 g delipidated cocoa. Venous blood samples were taken before and at 2 h and 4 h after consuming the cocoa. The oxidation lag time of LDL before cocoa ingestion was 59.0 +/- 6.3 min, but it was prolonged at 2 h after cocoa (68.3 +/- 6.0 min); before returning to the initial lag time (61.7 +/- 5.7 min) before consumption. Thus we have shown that cocoa inhibited LDL oxidation both in vitro and ex vivo.
Solvent Structure, Dynamics, and Ion Mobility in Aqueous Solutions at 25 °C (1998)

We calculate the mobilities ui of the metal cations Li+, Na+, K+, Rb+, Cs+, and Ca2+ and the halides F-, Cl-, Br-, and I- at infinite dilution by molecular dynamics simulation using the SPC/E model for water at 25 °C and a reaction field for the long-range interactions. The ion mobilities show the same trends as the experimental results with distinct maxima for cations and anions. The mobilities (defined by ui = Di/kT) of the corresponding uncharged species are also determined by simulation and are in qualitative agreement with Stokes' law. The mobilities of Li+, Na+, K+, Rb+ and F- increase on discharge, whereas Cl, Br, and I have smaller mobilities than the corresponding anions. The mobility of the fictitious I+ ion, which differs from I- only in its charge, lies between that of I- and I in the order uI < uI+ < uI−. The residence time of water in the first solvation shell of small cations (Li+ and Na+) and Ca2+ decreases when the ions are discharged, while the opposite is observed on neutralizing I-, suggesting the formation of a solvent cage around the large uncharged I which partially breaks up on charging, increasing the mobility of the corresponding ion. The cage breakup is greater for I- than for I+ which correlates with the asymmetry in the entropies of solvation of I- and I+, in SPC/E water on charge reversal, providing an explanation for the trends in the mobilities of I, I-, and I+. The residence times of water in the primary hydration shell around cations pass through a minimum as a function of size that correlates with the maximum in the corresponding solvation entropy, suggesting different types of hydration, i.e., electrostatic ion solvation (hydrophilic) and cage formation (hydrophobic) respectively for small and large cations. The results are in accord with recent calculations of the solvation entropy and free energy as continuous functions of the charge and size (Lynden-Bell, R. M.; Rasaiah, J. C. J. Chem. Phys. 1997, 107, 1981). Hydrophilic and hydrophobic solvation are reflected in the exchange dynamics of the water in the hydration shells around charged and uncharged solutes. The solvation dynamics of individual cations and anions are distinct at short times but characterized by the solvent at long times. Solvent dynamics, structure, and caging modulated by the charge and size of the ions are strongly implicated in determining their mobilities.
Grundlagen der Kautschukextrusion (2007)

No AccessPraxis der KautschukextrusionMar 2007Grundlagen der KautschukextrusionLothar Köster, Hans Perz, Georg TsiwikisLothar Köster, Hans Perz, Georg Tsiwikishttps://doi.org/10.3139/9783446411609.001SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2007Pages: 1-38Print ISBN: 978-3-446-40772-5eISBN: 978-3-446-41160-9 Copyright & Permissions© 2007 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Spectroscopic and Dynamic Studies of the Epidermal Chromophores <i>trans</i>-Urocanic Acid and Eumelanin (2000)

Photoaging and skin cancer can result from the exposure of skin to ultraviolet A (UV-A, 320-400 nm) radiation. The detailed chemical mechanisms by which these processes occur are not known, but they must begin with the absorption of a UV-A photon by one or more photoreceptor(s) within the skin. The situation is complicated by the lack of understanding of the photoreactions of many of the UV-A-absorbing molecules in skin. In this Account, we describe recent research efforts directed at elucidating the UV-A-induced photoreactivity of two light-absorbing epidermal photoreceptors: trans-urocanic acid and eumelanin.
Frequency driven repeater insertion for deep submicron (2004)

Repeaters now widely used to decrease delay and increase the performance of long interconnects. The maximum operating frequency is limited by the longest wire between two repeaters. The main goal of repeater insertion is to reduce the delay of the interconnects in a circuit. Increasing the number of repeaters on an interconnect increases the slew rate and the operating frequency but decreases the design performance in terms of area and power. This paper presents a new methodology of repeater insertion considering the circuit operating frequency to improve the slew rate and reduce the area overhead of the repeaters. We propose a mathematical treatment for finding the number and position of repeaters while keeping the same size of the optimal repeater size. Experimental results are shown for different frequencies and repeater sizes to indicate the improvements of slew rate and saving area overheard.
The family culture of negotiation—a result of changing parent‐child relationships (1994)

Abstract Case studies of parent‐child relations in three different European regions—West Germany, East Germany and the Netherlands—offer material for the comparative analysis of the ongoing intra‐familial process of modernization and civilization in post‐war West European societies. The data are drawn from extended narrative interviews with twelve‐year‐olds and from parallel but separate semi‐structured ‘mirrored’ interviews with the same children and their parents. The results of the analysis show that family relations in general, and parent‐child relations in particular, are increasingly marked by a familial ‘culture of negotiation’. This suggests that the balance of intergenerational power relations is currently in the process of change. To a greater or lesser extent, contemporary family relations are characterized by situationally grounded processes of negotiation between parents and children.
Simple electrode configuration for uv initiated high-power TEA laser discharges (1973)

A simple Rogowski electrode configuration with capacitively coupled arcs on the sides of the discharge is described. With this configuration the authors have succeeded in dumping up to 500 J/1 into a gas mixture with as little as 41% He. The resulting small-signal gain characteristics and discharge current waveform are described. A 3-m oscillator has yielded output power &gt; 1 GW and output energy of 125 J.
Adaptation to non-ammoniagenic medium and selective substrate feeding lead to enhanced yields in animal cell cultures (1990)

Methods for the adaptation of three animal cell lines to media in which glutamine is replaced with either glutamate or 2-oxoglutarate are described. The cell lines differ in their rate of adaptation. The consequences of the adaptation of the McCoy cell line to a glutamate-based medium was measured in terms of: cell yield (increased by 17%), ammonia accumulation (reduced by 70%), glucose consumption (decreased by greater than 70%) and lactate accumulation (decreased by greater than 75%). The value of such adaptation and concomitant changes in energy metabolism lies in the potential for increased cell yields. Batch feeding of adapted cells in a microcarrier culture with a cocktail of glucose and amino acids resulted in increases in cell yields of 80% compared to unfed controls.
Asphalt binders modified by SBS and SBS/nanoclays: effect on rheological properties (2012)

In this work, it was investigated the effect of organically modified vermiculite and montmorillonite (OVMT and OMMT, respectively) in asphalt binders (AB) modified by SBS (styrene-butadiene-styrene). The physical and rheological properties were performed for AB, 4.0% SBS MB and nanocomposite AB modified by 2.5% SBS with 2.5% of organoclays. The modified binders (MB) result in the enhancement of complex modulus (G*) and reduction of phase angle (d), which means greater resistance to permanent deformation. The viscosity, penetration and thermal susceptibility were appropriate. The black diagrams show that the effect of nanoclays OVMT and OMMT was similar to the effect of Cloisite®. The rheological properties of the nanocomposite were comparable to the 4.0% SBS MB, identifying a cost reduction due to the potential of replacing polymer with clay. The presence of OVMT improved the storage stability of SBS MB, an important result, as the phase separation is a major obstacle to the use of SBS in paving.
An architectural decision modeling framework for service oriented architecture design (2009)

In this thesis, we investigate whether reusable architectural decision models can support Service-Oriented Architecture (SOA) design. In the current state of the art, architectural decisions are captured ad hoc and retrospectively on projects; this is a labor-intensive undertaking without immediate benefits. On the contrary, we investigate the role reusable architectural decision models can play during SOA design: We treat recurring architectural decisions as first-class method elements and propose an architectural decision modeling framework and a reusable architectural decision model for SOA which guide the architect through the SOA design. Our approach is tool supported. Our framework is called SOA Decision Modeling (SOAD). SOAD provides a technique to systematically identify recurring decisions. Our reusable architectural decision model for SOA conforms to a metamodel supporting reuse and collaboration. The model organization follows Model-Driven Architecture (MDA) principles and separates long lasting platform-independent decisions from rapidly changing platform-specific ones. The alternatives in a conceptual model level reference SOA patterns. This simplifies the initial population and ongoing maintenance of the decision model. Decision dependency management allows knowledge engineers and software architects to check model consistency and prune irrelevant decisions. Moreover, a managed issue list guides through the decision making process. To update design artifacts according to decisions made, decision outcome information is injected into design model transformations. Finally, a Web-based collaboration system provides tool support for the framework steps and concepts. The SOAD framework is not only applicable to enterprise application and SOA design, but also to other application genres and architectural styles. SOAD supports use cases such as education, knowledge exchange, design method, review technique, and governance instrument.
NetAuth: supporting user-based network services (2008)

In User-Based Network Services (UBNS), the process servicing requests from user U runs under U ’s ID. This enables (operating system) access controls to tailor ser-vice authorization toU. Like privilege separation, UBNS partitions applications into processes in such a way that each process ’ permission is minimized. However, be-cause UBNS fundamentally affects the structure of an application, it is best performed early in the design pro-cess. UBNS depends on other security mechanisms, most notably authentication and cryptographic protections. These seemingly straightforward needs add considerable complexity to application programming. To avoid this complexity, programmers regularly ignore security is-sues at the start of program construction. However, after the application is constructed, UBNS is difficult to ap-ply since it would require significant structural changes to the application code. This paper describes easy-to-use security mechanisms supporting UBNS, and thus significantly reducing the complexity of building UBNS applications. This sim-plification enables much earlier (and hence more effec-tive) use of UBNS. It focuses the application developer’s attention on the key security task in application develop-ment, partitioning applications so that least privilege can be effectively applied. It removes vulnerabilities due to poor application implementation or selection of security mechanisms. Finally, it enables significant control to be externally exerted on the application, increasing the abil-ity of system administrators to control, understand, and secure such services. 1
Planar monopole in wrapped structure for low-profile GSM/DCS mobile phone antenna (2002)

A novel planar monopole consisting of two sub-patches and wrapped into a compact structure with a height of 10 mm for 900 and 1800 MHz operation is presented. The antenna can be mounted on the top portion of a mobile phone housing a small distance (4 mm) from the ground plane, resulting in a low profile of 14 mm (about 4.2% of the wavelength at 900 MHz), and the obtained 10 dB return-loss impedance bandwidths cover the GSM (880–860 MHz) and DCS (1710–1880 MHz) bands.
Transcranial doppler sonography to monitor cerebral vasculitis. (1996)

We describe a patient with cerebral vasculitis treated with prednisone and cyclophosphamide and followed by serial transcranial Doppler sonography and arteriography. Proximal cerebral angiographic abnormalities correlated with transcranial Doppler abnormalities. The abnormalities gradually normalized with treatment and correlated with the findings of followup arteriography, which also showed improvement in the vascular morphology. Transcranial Doppler sonography is useful in following proximal cerebral vascular abnormalities in some cases of cerebral vasculitis.
Coordinating Autonomous Planning Agents with Temporal Constraints (2006)

We address the problem of coordinating autonomous agents that have to come up with a joint plan and schedule for a set of tasks. These tasks are interdependent and temporally constrained and are distributed over the agents. We start with investigating the scheduling part of the problem: How to achieve, given the constraints, a joint solution to the distributed scheduling problem where each of the agents is allowed to determine its own schedule for the set of tasks assigned to it. Here, the problem is to ensure that whatever individual schedule each agent comes up with, these schedules always can be combined into a global schedule satisfying all constraints. Next, we investigate a more complex problem where, before scheduling, the agents are allowed to make their own plan to achieve the tasks assigned to them. That is, they are allowed to choose autonomously some additional precedence constraints to their assigned tasks. We have to provide the necessary coordination mechanisms to ensure that no conflicts will arise between the resulting plans. The solution we provide is to reduce the temporal constraints of the individual tasks to a set of precedence constraints between tasks and virtual tasks and we solve the resulting coordination problem for tasks with precedence constraints. The solution thus obtained enables us to solve the plan coordination problem with temporal constraints. 1
Role of mecA transcriptional regulation in the phenotypic expression of methicillin resistance in Staphylococcus aureus (1996)

The gene required for methicillin resistance in staphylococci, mecA, encodes the low-affinity penicillin-binding protein 2a (PBP2a). Transcriptional regulation of mecA is accomplished in some isolates by mecR1 and mecI, cotranscribed chromosomal genes that encode a putative signal transducer and a transcriptional repressor, respectively. Two Staphylococcus aureus strains that have identical mecR1-mecI nucleotide sequences, BMS1 and N315P, both exhibit low-level, heterotypic expression of methicillin resistance and contain no beta-lactamase coregulatory sequences. mecR1-mecI was amplified from BMS1 by PCR and was shown to be functional on a high-copy-number plasmid when introduced into an S. aureus strain with a deleted mecR1-mecI locus. Cloned mecR1-mecI repressed phenotypic expression of methicillin resistance, mecA transcription and PBP2a production and mediated PBP2a induction in response to certain beta-lactam antibiotics. However, mecR1-mecI had different regulatory activities in its native chromosomal location in N315P compared with those in BMS1. Uninduced mecA transcription was markedly repressed in N315P, and mecI inactivation increased mecA transcription and PBP2a production 5- and 40-fold, respectively. Furthermore, the N315P phenotype changed from low-level, heterotypic resistance with intact mecI to high-level, homotypic resistance in strains with disrupted mecI. In contrast, uninduced BMS1 produced abundant mecA transcript and PBP2a, while the disruption of mecI had no effect on phenotype and little effect on mecA transcription or PBP2a production. Thus, mecI-mediated repression of mecA appears to be dysfunctional in BMS1 because of the presence or absence of additional regulatory cofactors. Furthermore, heterotypic resistance expression in this strain is independent of mecA transcriptional regulation.
A New Stabilized Zero - Crossing Representation In The Wavelet Transform Domain And Its Application To Image Processing (1996)

Publication in the conference proceedings of EUSIPCO, Trieste, Italy, 1996
Two paths to interoperable metadata (2003)

This paper describes a prototype for a Web service that translates between pairs of metadata schemas. Despite a current trend toward encoding in XML and XSLT, we present arguments for a design that features a more distinct separation of syntax from semantics. The result is a system that auomates routine processes, has a well-defined place for human input, and achieves a clean separation of the document data model, the document translations, and the machinery of the application.
Motion planning based on hierarchical knowledge using genetic programming (2003)

There are many researches about the motion planning problem. In this field, main research is to generate the motion for specific robot and task without the previously acquired motions. We consider the motion planning by reusing knowledge. It is our object to realize the hierarchical knowledge with reusing. In this paper, we adopt tree-based representation for expressing the knowledge of the motion and adopt genetic programming as a learning method. We construct the motion planning system using the hierarchical knowledge. We apply the proposed method to the six legged locomotion robot to show its availability.
Vitamin D Deficiency in Cystic Fibrosis (2020)

Cystic Fibrosis is the most common inherited genetic respiratory disorder in the Western World. Hypovitaminosis D is almost universal in CF patients, likely due to a combination of inadequate absorption, impaired metabolism, and lack of sun exposure. Inadequate levels are associated with the high prevalence of bone disease or osteoporosis in CF patients, which is associated with increased morbidity including fractures, kyphosis, and worsening pulmonary status. Treatment goals include regular monitoring 25 hydroxyvitamin D (25OHD) levels with aggressive treatment for those with levels <75 nmol/L (<30 ng/mL). More research is needed to determine optimal supplementation goals and strategies.
Improved rate of convergence in Kohonen neural network (2002)

The neighborhood interaction function selection in the Kohonen self-organizing feature map neural network is analyzed for improving the rate of convergence. The definition of the neighborhood interaction function is motivated by anatomical evidence as opposed to what is currently used, which is a uniform neighborhood interaction set. By selecting a neighborhood interaction function with a neighborhood amplitude of interaction which is decreasing in the spatial domain the topological order is always enforced and the rate of self-organization to final equilibrium state is improved. A simulation is carried out to show the convergence rate improvement achieved using a neighborhood interaction function vs. using a neighborhood interaction set. An error measure functional is further defined to compare the two approaches quantitatively.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Bovine T lymphocytes. I. Generation and maintenance of an interleukin-2-dependent, cytotoxic T-lymphocyte cell line. (1986)

Primary and secondary bovine allogeneic mixed leucocyte cultures were examined for the generation of antigen-specific cytotoxic leucocytes. While optimal generation of murine and human cytotoxic T lymphocytes typically requires 4-8 days, alloantigen-specific cytotoxic bovine leucocytes were demonstrated consistently only after prolonged incubation periods, optimally found to be about 15 days. Restimulation of long-term bovine mixed leucocyte cultures with the original stimulator population revealed responder cells demonstrating augmented alloantigen-specific lytic activity. When placed into human recombinant interleukin-2, responder cells expanded and required passaging every 3-4 days. The same was not true of cells placed into interleukin-2-free medium. Cells cultured in interleukin-2-containing medium retained alloantigen specificity after 10 weeks of culture. Moreover, they continued to display total dependence on human, simian or bovine interleukin-2 for growth.
<i>In Vivo</i>Biodistribution of Nanoparticles (2011)

Nanoparticles have potential applications in diagnostics, imaging, gene and drug delivery and other types of therapy. Iron oxide nanoparticles, gold nanoparticles and quantum dots have all generated substantial interest and their properties and applications have been thoroughly studied. Yet, metal-containing particles raise biodistribution and toxicity concerns because they can be quickly cleared from the blood by the reticuloendothelial system and can remain in organs, such as the liver and spleen, for prolonged periods of time. Design considerations, such as size, shape, surface coating and dosing, can be manipulated to prolong blood circulation and enhance treatment efficacy, but nonspecific distribution has thus far been unavoidable. Renal excretion of nanoparticles is possible and is size dependent, but the need to incorporate coatings to particles for increased circulation can hinder such excretion. Further long-term studies are needed because recent work has shown varying degrees of in vivo toxicity as well as varying levels of nanoparticle excretion over time. The interaction of these particles with immune cells and their effect on the innate and adaptive immune response also needs further characterization. Finally, more systematic in vitro approaches are needed to both guide in vivo work and better correlate nanoparticle properties to their biological effects.
Electronic Data Transfer: (1994)

Abstract This article provides an overview of Electronic Data Interchange as it applies to serials acquisitions. and examines the steps followed in planning to link two systems, Bibliotech, an inlegated library system, and EBSCONET. the Ebsco Subscription Service on-line service, at Raweon's Equipment Division Technical Information Center. Benefits of electronic data interchange are discussed and the role of the serials librarian as a manager of computer to computer data transmission is addressed.