gebhart/patrepeval huggingface dataset:
Selective aerobic oxidative dehydrogenation of alcohols and amines catalyzed by a supported molybdenum-vanadium heteropolyanion salt Na5PMo2V2O40 (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective aerobic oxidative dehydrogenation of alcohols and amines catalyzed by a supported molybdenum-vanadium heteropolyanion salt Na5PMo2V2O40Ronny Neumann and Michal LevinCite this: J. Org. Chem. 1991, 56, 19, 5707–5710Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/jo00019a047https://doi.org/10.1021/jo00019a047research-articleACS PublicationsRequest reuse permissionsArticle Views1391Altmetric-Citations152LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
POSAML: A Visual Modeling Framework for Middleware Provisioning (2007)

Effective provisioning of next generation distributed applications hosted on diverse middleware platforms incurs significant challenges due to the applications' growing complexity and quality of service (QoS) requirements. An effective provisioning of the middleware platform includes a composition and configuration of the middleware services that meets the application QoS requirements under expected workloads. Traditional techniques for middleware provisioning tend to use non-intuitive, low-level and technology-specific approaches, which are tedious, error prone, non-reusable and not amenable to ease of QoS validation. Additionally, most often the configuration activities of the middleware platform tend to be decoupled from the QoS validation stages resulting in an iterative trial-and-error process between the two phases. This paper describes the design of a visual modeling language called POSAML (patterns oriented software architecture modeling language) and associated tools that provide an intuitive, higher level and unified framework for provisioning middleware platforms. POSAML provides visual modeling capabilities for middleware-independent provisioning while allowing automated middleware-specific QoS validation
A Distributed Measurement System for Locating Transient-Voltage Sources (2006)

The use of a distributed measurement system to locate the source of transient voltages is discussed in this paper. The system implements a method based on the measurement of the starting instants of a transient in the nodes of the monitored network. The method performance is investigated by simulating the system operation. Results in the case of both faults and insertion of capacitors in a IEEE test network are presented and discussed.
Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells (2009)

Inheritance of epigenetic information encoded by cytosine DNA methylation patterns is crucial for mammalian cell survival, in large part through the activity of the maintenance DNA methyltransferase (DNMT1). Here, we show that SET7, a known histone methyltransferase, is involved in the regulation of protein stability of DNMT1. SET7 colocalizes and directly interacts with DNMT1 and specifically monomethylates Lys-142 of DNMT1. Methylated DNMT1 peaks during the S and G(2) phases of the cell cycle and is prone to proteasome-mediated degradation. Overexpression of SET7 leads to decreased DNMT1 levels, and siRNA-mediated knockdown of SET7 stabilizes DNMT1. These results demonstrate that signaling through SET7 represents a means of DNMT1 enzyme turnover.
A new route to 2‐amino‐ or 2‐hydroxy‐3‐pyridinecarboxylic acid derivatives (1989)

Abstract Schiff's bases derived from ketones and t ‐butylamine ( 1 ) reacted with methyl methoxymethylenemalonate to give 2‐hydroxy‐3‐pyridinecarboxylates. Similarly, treatment of 1 with ethoxymethylenemalononitrile gave 2‐amino‐3‐pyridinecarbonitriles. Compounds 1 on reaction with ethyl 2‐cyano‐3‐ethoxypropenoate afforded 2‐amino‐3‐pyridinecarboxylates.
注意“颜”外之意 (2006)

英语中表示颜色的词除了表示色彩外，还有其他一些用法．常见的如表示姓名：Mr Green（格林先生），Mrs White（怀特夫人），Miss Black（布莱克小姐），Mr Brown（布朗先生）等。
Applications of a CMOS current squaring circuit in analog signal processing (2015)

Applications of a CMOS squaring circuit in analog signal processing is studied in this paper. The circuit is based on the dual translinear loop and square-law characteristic of MOS transistor in saturation region. The reconfigurable circuit is employed as a basic analog cell for the implementation of several building blocks including multiplier, logarithmic, divider and exponential function generator circuits. It is proposed a solution for implamentation of the analog logarithmic and exponential functions, which are not an easily accessible characteristic in CMOS technology, as well as their integration in a configurable cell. Current-mode implementation of the circuits leads to straightforward and intuitive configurations. To study the performance of the circuit, effects of channel-length modulation as well as the mismatch in the threshold voltages are thoroughly discussed. The proposed circuits are designed and simulated using HSPICE simulator by level 49 parameters (BSIM3v3) in 0.35 μm standard CMOS technology. MATLAB results validate the simulation results which are obtained by HSPICE.
Tests for resistivity boundary changes at Ohaaki, New Zealand (1994)

Close-spaced resistivity measurements along ten traverse lines crossing the resistivity boundary of the Ohaaki Geothermal Field, New Zealand, were first measured in 1975 and remeasured in 1992. The 1992 resistivity profiles were similar in shape to the original ones. On both occasions very sharp resistivity boundaries were delineated along the southern and southwestern edges of the field where apparent resistivity rises sharply over a horizontal distance of a few hundred metres from 2-5 ohm m on the inside of the field to 20-50 ohm m on the outside. On two of the southern lines the resistivity boundary appears to have moved outwards by about 100 m, which may be caused by southward movement of reinjected waste water from nearby drillholes. On the other southern lines the outward movement appears to be less than about 25 m, which is the limit of resolution of the survey. Over the 17 year interval apparent resistivity values have dropped slightly at most measurement sites. The decrease is more pronounced on the inside of the field boundary where apparent resistivities have declined by up to about 40 percent. Some of this decrease is attributed to reinjection of conductive waste water near the field boundary causing a drop in ground resistivity. Part of this change may be due to calibration errors and measurement difficulties, including the disturbing effects of the new drillholes, steam pipes and an earthing mat that have been installed since 1975.
Osteonectin, bone proteoglycan, and phosphophoryn defects in a form of bovine osteogenesis imperfecta. (1984)

Bovine osteogenesis imperfecta is a congenital disease in Holstein cattle having several characteristics in common with human osteogenesis imperfecta syndromes. In particular, affected calves have multiple bone fractures and friable teeth. Bone collagen isolated from the affected animals (Texas variant) showed slightly decreased alpha 1(I) and alpha 2(I) chain electrophoretic mobility and increased hydroxylysine content. Overall collagen was present in the affected bones at 80-90% of normal values. However, osteonectin, a 32,000 Mr bone-specific protein found previously to promote collagen mineralization in vitro and present in abundance (approximately equal to 3% of total protein) in normal calf bone, was severely depleted (less than 2% of normal levels) in the osteogenesis imperfecta bone and dentin. The bone proteoglycan was similarly depleted. In contrast, the bone sialoprotein was not as severely affected. Further, the diseased teeth lacked (less than 10% of normal values) phosphophoryn, a dentin-specific protein normally present as 4-5% of the total calf dentin matrix. The data suggest multiple hard tissue matrix protein deletions, perhaps due to impaired cell development.
Abstract C169: Intermittent dosing of Imetelstat Sodium, a telomerase inhibitor, induces drug exposure consistent with <i>in vivo</i> tumor growth inhibition (2009)

Abstract Background: Telomerase maintains telomere length (TL) of dividing cells, and is essential for cell immortalization. Telomerase is upregulated in tumors, particularly in cancer progenitor cells. Imetelstat (GRN163L), the first targeted telomerase inhibitor in clinical trials, is a 13-mer lipidated oligonucleotide that binds to the template RNA strand of telomerase. With weekly dosing, thrombocytopenia was dose limiting and MTD was 4.8 mg/kg. To increase drug exposure and maintain tolerability, we tested an intermittent dosing schedule of imetelstat. Methods: Patients (pts) with advanced solid cancers were given imetelstat as a single agent by 2 hr. i.v. infusions on D1 and D8 of 21-Day cycles (Cy), starting at 4.8 mg/kg. A 3+3 dose escalation was used. Pre-treatment granulocyte TL (PMN TL), a surrogate of hematopoietic progenitor TL, was measured by Flow-FISH. Results: 31 pts have been treated, with 4 currently on study. Mean number of prior cytotoxic regimens reported for 26 pts was 3.6 and 16 pts had prior irradiation. Dose escalation proceeded to 11.7 mg/kg, which was judged to be in excess of the MTD due to cytopenias. Three pts had been previously treated with 9.4 mg/kg without DLT, and the 9.4 mg/kg cohort was subsequently expanded to 12 pts, maintaining q21 D dosing. To date, severe myelosuppression has been observed in only 1 pt, and all 12 completed Cy 1. Three pts had doses held in Cy 2 for thrombocytopenia. Eight pts discontinued treatment after completing 1 to 4 Cy, 6 for PD, 1 for a hypersensitivity reaction and 1 for an unrelated SAE. Four pts are currently on treatment and have completed 2 to 3 Cy. Hypersensitivity reactions were observed in 5 of 31 pts dosed to date and were associated with biochemical evidence of complement activation; one was managed with secondary prophylaxis with steroids and antihistamines, and routine primary prophylaxis was subsequently instituted for all patients. Transient (&lt;24hr) prolongation of aPTT occurs without clinical sequelae. Other AEs were non-specific, mild to moderate and of dubious causality. Mean ± SD (N) imetelstat AUC-inf from pts treated with 7.5, 9.4 and 11.7 mg/kg were 1036 ± 359 (3), 1219 ± 109 (2) and 1408 ± 812 (6), respectively. By comparison, antitumor effects were noted in xenograft models with AUC-inf of 819. Preliminary analysis of pre- and post-treatment hair follicle samples for pharmacodynamic activity suggests a trend for telomerase inhibition. As previously noted*, thrombocytopenia correlated with short baseline PMN TL among 17 pts. Conclusions: Intermittent dosing of imetelstat at 9.4 mg/kg was well tolerated for multiple cycles. Drug exposures were in a range associated with antitumor activity in preclinical models and preliminary evidence of a pharmacodynamic effect has been observed. Hematologic toxicity is doselimiting, and may be mechanism-based. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):C169.
Ž. B. Šaknys Jaunimo brandos apeigos Lietuvoje XIX a. pabaigoje- XX a. pirmojoje pusėje Lietuvos etnologija, I, Vilnius, 1996. 212 p./Ž. B. Šaknys, Youth Initiation Rites in Lithuania (end of the nineteentth- first half of the twentieth centuries) Lietuvos etnologija, I, Vilnius, 1996. 212 pp. (1997)

"Ž. B. Šaknys Jaunimo brandos apeigos Lietuvoje XIX a. pabaigoje- XX a. pirmojoje pusėje Lietuvos etnologija, I, Vilnius, 1996. 212 p./Ž. B. Šaknys, Youth Initiation Rites in Lithuania (end of the nineteentth- first half of the twentieth centuries) Lietuvos etnologija, I, Vilnius, 1996. 212 pp." published on 30 Nov 1997 by Brill | Schöningh.
ANALOG MAXIMUM POWER POINT CIRCUIT APPLIED TO THERMOGENERATORS (2008)

The objective of maximum power point tracking (MPPT) circuits is to find automatically the MPP and therefore extract the maximum amount of power available in the energy supplier (e.g. TEGs, solar cells). Nowadays, the most common techniques of MPPT employ DSPs or microcontrollers. However, simpler solutions employing analog circuits already exist but the power consumption and complexity of these solutions is still not fully optimized. This paper presents a MPPT circuit implemented with four low-power operational amplifiers.
Cooperation and Coordination Between Fuzzy Reinforcement Learning Agents in Continuous State Partially Observable Markov Decision Processes (1999)

Successful operations of future multi-agent intelligent systems require efficient cooperation schemes between agents sharing learning experiences. We consider a pseudo-realistic world in which one or more opportunities appear and disappear in random locations. Agents use fuzzy reinforcement learning to learn which opportunities are most worthy of pursuing based on their promise rewards, expected lifetimes, path lengths and expected path costs. We show that this world is partially observable because the history of an agent influences the distribution of its future states. We consider a cooperation mechanism in which agents share experience by using and-updating one joint behavior policy. We also implement a coordination mechanism for allocating opportunities to different agents in the same world. Our results demonstrate that K cooperative agents each learning in a separate world over N time steps outperform K independent agents each learning in a separate world over K*N time steps, with this result becoming more pronounced as the degree of partial observability in the environment increases. We also show that cooperation between agents learning in the same world decreases performance with respect to independent agents. Since cooperation reduces diversity between agents, we conclude that diversity is a key parameter in the trade off between maximizing utility from cooperation when diversity is low and maximizing utility from competitive coordination when diversity is high.
Beneficial effects of probiotics in upper respiratory tract infections and their mechanical actions to antagonize pathogens (2012)

Probiotics are live micro-organisms with beneficial effects on human health, which have the ability to counteract infections at different locations of the body. Clinical trials have shown that probiotics can be used as preventive and therapeutic agents in upper respiratory tract infections (URTIs) and otitis. Their mechanical properties allow them to aggregate and to compete with pathogens for nutrients, space and attachment to host cells. Consequently, they can directly antagonize pathogens and thus exert beneficial effects without directly affecting the metabolism of the host. An overview of the probiotics with such traits, tested up to date in clinical trials for the prevention or treatment of URTIs and otitis, is presented in this review. Their mechanical properties in the respiratory tract as well as at other locations are also cited. Species with interesting in vitro properties towards pharyngeal cells or against common respiratory pathogens have also been included. The potential safety risks of the cited species are then discussed. This review could be of help in the screening of probiotic strains with specific mechanical properties susceptible to have positive effects in clinical trials against URTIs.
ChemInform Abstract: Structural and Electrochemical Performances of Li<sub>4</sub>Ti<sub>5‐x</sub>Zr<sub>x</sub>O<sub>12</sub> as Anode Material for Lithium‐Ion Batteries. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The control of globin and other eukaryotic genes (1982)

The hypothesis is advanced that eukaryotes control different parts of their genomes by the selective use of origins of replication. Replication of a gene from an origin upstream of the gene is postulated to open it for transcription under appropriate circumstances; replication of a gene from an origin downstream of the gene closes it. The applicability of this hypothesis to the control of the human beta-globin cluster of genes is considered.
Energy Management in Smart Distribution Systems With Vehicle-to-Grid Integrated Microgrids (2016)

In modern electric power systems, plug-in electric vehicle (PEV) with vehicle-to-grid (V2G) potential are becoming reliable and flexible resources for energy balancing under varying energy supply and demand scenarios. In this evolving paradigm, designing energy management strategies for feasible and cost-effective utilisation of V2G is one of the several challenges faced by the utility operators and regulators. This paper proposes two energy management strategies to effectively utilize V2G potential of PEVs in managing energy imbalances in grid-connected microgrids. The contributions of this paper are in twofold. First, it proposes a novel bidding strategy for PEVs offering V2G by including the projected battery degradation cost to integrate them into microgrid operation. Second, two energy management strategies are proposed for inclusion of V2G into the microgrid operation based on the forecast accuracy on energy supply and demand, and market prices. The proposed V2G integration strategies are implemented using a multi-agent system developed in Java agent development framework and applied to a microgrid case study system. The simulation results and their analysis show that V2G can be used to maximum depth of discharge levels if the electricity price variation is high and battery cost of PEVs is low.
Transceiving antenna for homogeneous heating andradiometric thermometry during hyperthermia (2000)

The authors describe a conformal microwave applicator fabricated from thin, flexible, multi-layer printed circuit board material that facilitates the hyperthermic heating of surface areas covering contoured regions of the anatomy. An antenna structure which combines the axial beam characteristics of an Archimedian spiral antenna with the omni-directional radiation pattern of an annular slot dual concentric conductor antenna is studied with the aim of achieving homogeneous heating simultaneously with non-invasive thermometry of tissue under the applicator.
A Modified Electro-Mechanical Impedance Model of Piezoelectric Actuator-Sensors for Debonding Detection of Composite Patches (2002)

A modified electro-mechanical impedance model of piezoelectric actuator-sensors is presented in this study. The presented model treats the bonding layer between a piezoelectric patch and a host structure as a spring-mass-damper system in the coupled electro-mechanical analysis. The effect of bonding layers on the dynamic interaction between piezoelectric actuator-sensors and host structures is thus taken into account. The model is then used for debonding detection of composite patches. A debonding model is accordingly developed. The debonding model uses infinitesimal-length springs to model the joint between a composite patch and its base structure. The spring stiffness varies with the joint rigidity and directly influences the structural mechanical impedance as well as the piezoelectric electric admittance. A numerical example is provided to reveal the effect of bonding layers and demonstrate the feasibility of the proposed detection method.
A Novel <i>cis</i> -Acting Element Required for Lipopolysaccharide-Induced Transcription of the Murine Interleukin-1β Gene (1995)

Regulatory elements important for transcription of the murine interleukin-1 beta (IL-1 beta) gene lie within a DNase I-hypersensitive region located > 2,000 bp upstream from the transcription start site. We have identified within this region a novel positive regulatory element that is required for activation of an IL-1 beta promoter-chloramphenicol acetyltransferase (CAT) fusion gene in the murine macrophage line RAW264.7. Electrophoretic mobility shift analysis of the 3' portion (-2315 to -2106) of the hypersensitive region revealed at least two nuclear factor binding sites, one of which is located between positions -2285 and -2256. Competitive inhibition studies localized the binding site to a 15-bp sequence between -2285 and -2271. Nuclear factor binding was lost by mutation of the 6-bp sequence from -2280 to -2275. The specific retarded complex formed with RAW264.7 nuclear extract was not detected under similar conditions with nuclear extracts from RLM-11, a murine T-cell line which does not express IL-1 beta RNA. Mutation of the 6-bp sequence (-2280 to -2275) in the chimeric IL-1 beta promoter -4093 +I CAT plasmid virtually eliminated the activation of this reporter gene by lipopolysaccharide (LPS) in transfected RAW264.7 cells. Multimerization of the 15-bp sequence containing the core wild-type 6-bp sequence 5' of minimal homologous or heterologous promoters in CAT reporter plasmids resulted in significant enhancement of CAT expression compared with parallel constructs containing the mutant 6-bp core sequence. This element was LPS independent and position and orientation dependent. The multimerized 15-bp sequence did not enhance expression in RLM-11 cells. Methylation interference revealed contact residues from -2281 to -2271, CCAAAAAGGAA. Because a search of the NIH TFD data bank with the 11-bp binding site sequence found no homology to known nuclear factor binding sites, we have designated this sequence the IL1 beta -upstream nuclear factor 1 (IL1 beta -UNF1) target. UV cross-linking and sodium dodecyl sulfate-polyacrylamide electrophoresis identified an IL1 beta -UNF1-specific binding factor approximately 85 to 90 kDa in size.
Stability analysis for a semiconductor laser in an external cavity (1984)

A detailed theoretical analysis of stability is presented for a semiconductor laser in an external cavity. The limits of stable operation are determined as a function of the external cavity parameters and the linewidth enhancement factor α. Instability is related to jumps of the laser frequency between external cavity modes (frequency bistability) or to feedback-induced intensity pulsations due to the carrier density dependence of the refractive index. The limit of bistability is derived from the steady-state solutions of the rate equations and the intensity pulsation limit is obtained from a small-signal analysis. This analysis also gives the location of zeros in the system determinant and the resulting FM noise spectrum. For practical applications we emphasize the determination of the stable tuning range for the phase in the external cavity and the classification of the possible types of instability for various feedback levels.