gebhart/patrepeval huggingface dataset:
Cell kinetics and tumor regression during radiotherapy in head and neck squamous-cell carcinomas (1996)

Head and neck squamous-cell carcinoma (HN-SCC) patient management is mainly based on TNM classification and needs be improved by considering other potentially useful prognostic factors. We examined the pre-radiotherapy tumor potential doubling time (Tpot) evaluated after in vivo infusion of bromodeoxyuridine and flow-cytometric analysis and the early clinical tumor regression after 40 Gy (40 Gy-TR). Tpot values and clinical 40 Gy-TR classes (minor and major) were available for 82 HN-SCC patients. Radiation therapy completion was done either with 1 dose per day (conventional regimen) or 2 doses per day (accelerated regimen). Local control was also available for follow-up times above 4 years. We found that major 40 Gy-TR was strongly correlated with fast tumor growth, characterized by Tpot values below 5 days, and that patients with major 40 Gy-TR showed better local control than those with minor 40 Gy-TR, independently from the radiotherapy regimen type. We also found that treatment completion with accelerated radiotherapy gave better local control for patients with major 40 Gy-TR and fast tumor growth than conventional radiotherapy. Multivariate analysis, performed on all patients, assigned an independent prognostic value to Tpot, tumor classification and 40 Gy-TR.
Graft copolymers of <i>para</i>‐hydroxybenzoic acid (PHB). I. A general method for grafting mesogenic oligo‐PHB to oligomers (1987)

Abstract A method for grafting oligo‐( p ‐hydroxybenzoic acid) to carboxyl‐functional oligomers or polymers to give copolymers having mesogenic side chains was developed. The method employs dicyclohexylcarbodiimide (DCC) to promote esterification of PHB at mild temperatures and to remove water. Pyridine is used as solvent, and catalytic amounts of p ‐TSA are added to suppress side reactions. Grafting efficiencies are estimated to range from 74 to 90%. Ungrafted oligo‐PHB and other by‐products are readily removed. Structure assignments were supported by IR, 1 H‐NMR, GPC, DSC and model compound studies. The method appears capable of grafting oligo‐PHB side chains to any pyridine soluble oligomer or polymer having carboxyl groups and no other reactive groups that could interfere.
Dependence of optical gain on crystal orientation in surface-emitting lasers with strained quantum wells (1994)

We analyze theoretically optical gains in vertical-cavity surface-emitting lasers (VCSELs) for various crystal orientations. The calculation based on the multiband effective-mass theory takes into account the effects of anisotropy and nonparabolicity on the valence subband dispersion. It is found that in VCSELs employing InGaAs/InP strained quantum wells (QWs) with non-(001) orientations except (111), the polarization in the QW plane can be controlled and high gains are obtained. In particular, the gains in VCSELs with (NN1)-oriented (N≥2) strained QWs are markedly higher than those in the equivalent (001) lasers.
Effect of source inductance on controlled var operation of 12- pulse converter (2009)

This paper presents a detailed investigation of controlled Var operation of 12-pulse thyristor converter operating under asymmetrical firing angle mode. The Converter is analyzed for constant active power operation and constant reactive power operation. The effect of source inductance on the operation for controlled p-q is analysezed. The different combinations of firing angles for converter 1 and converter 2 can be found to do such operation. The study shows that the best 12-pulse converter operation condition will be at Var level of 0.5 p.u., without source inductance which provides the widest range of active power control[2]. With source inductance the best operating condition is above 0.5p.u. The presence of 6 p ±1harmonics in the input current, THD i in the input current is more severe in asymmetrical mode as compared to the equal firing angle mode [6].
A Constant Gm CMOS Op-Amp with Rail-to-Rail input/output stage (2010)

A Constant-gm CMOS op-amp with Rail-to-Rail input and output stage is proposed in this paper. It is based on a novel configuration that consists of four MOSFETS as dummy differential pairs to select different differential pair as input pair, according to the different common-mode voltage. The constant gm is accomplished by avoiding the input NMOS and PMOS differential pairs operating synchronously, if they operate at the same time, the tail current will be halved. The gate of the dummy differential pairs is controlled by a fixed dc voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</sub> . The resulting gm is constant within 4.65%. In addition, a class-AB output stage is employed to obtain a wide output range. The scheme can work properly for 1.5V~3.3V or 2.5V~5.5V depended on the process selected. The Op Amp performs 106.6-dB dc gain, 13.85-MHz bandwidth (PM=63.86°) at 10pF//10KΩ output load and 5V power supply.
APPLICATIONS OF BIOINFORMATICS TO NON-CODING RNAS IN THE ERA OF NEXT-GENERATION SEQUENCING (2013)

The human genome encodes a large number of non-coding RNAs, which employ a new and crucial layer of biological regulation in addition to proteins. Technical advancement in recent years, particularly, the wide application of next generation sequencing analysis, provide an unprecedented opportunity to identify new non-coding RNAs and investigate their functions and regulatory mechanisms. The aim of this workshop is to bring together experimental and computational biologist to exchange ideas on non-coding RNA studies.
Correction of defective expression in MHC class II deficiency (bare lymphocyte syndrome) cells by retroviral transduction of CIITA (1997)

Retrovirus-mediated gene transfer was used to restore expression to MHC class II-negative patient cells from complementation group A(II) of MHC class II immunodeficiency or bare lymphocyte syndrome (BLS). The cells of these patients do not transcribe MHC class II genes due to a defect in the trans-acting factor, CIITA. We constructed a vector, pGAG/Ii-CIITA, with the MHC class II-associated invariant chain promoter driving CIITA expression. Cocultivation with the virus producer line was consistently shown to be the optimal method for infection of all cell types. The induction of MHC class II expression after virus infection was rapid, and high levels of expression were achieved in cell lines within 1 wk of infection. In addition, expression was easily detectable even in peripheral blood cells of a BLS patient within a few days. Cell lines maintained in vitro for several months remained positive, and the proportion of cells with surface expression of DR was correlated with the number of integrated proviruses. Moreover, transduced B lymphoblastoid cell lines readily established tumors in CB17-scid/scid mice, and the MHC class II-positive cells demonstrated a clear competitive advantage in vivo. Ultimately, we hope to use this transduction system to restore normal immune function to a BLS patient for which no other therapeutic option currently exists.
The Fy<sup>a</sup>, Fy6 and Fy3 epitopes of the Duffy blood group system recognized by new monoclonal antibodies: identification of a linear Fy3 epitope (2003)

Four new anti-Duffy murine monoclonal antibodies (MAbs): two anti-Fy6 (MIMA-107 and MIMA-108), one anti-Fya (MIMA-19) and one anti-Fy3 (MIMA-29) were characterized. Identification of epitopes by means of synthetic peptides (Pepscan) showed that the anti-Fy6 reacted most strongly with peptides containing the sequence 19QLDFEDV25 of the Duffy glycoprotein, and less strongly with peptides containing LDFEDV (MIMA-107) or LDF only (MIMA-108). The anti-Fya recognized epitope 38DGDYGA43 containing the Gly42 residue, which defines the Fya blood group antigen. MIMA-29 is the first anti-Fy3 reactive with a linear epitope 281ALDLL285 located in the fourth extracellular domain (ECD4, loop 3) of the Duffy glycoprotein. The four new antibodies extend the list of six anti-Fy MAbs formerly characterized by Pepscan analysis that allow some general conclusions. Fine specificities of various anti-Fya, or anti-Fy6 are not identical, but all of them recognize linear epitopes located around, respectively, Gly42 or between two potential N-glycosylation sites at Asn16 and Asn27. Anti-Fy3 recognize either a linear epitope located in ECD4, or a conformational epitope that includes amino acid residues of ECD4 and of other ECDs.
Interleukin-4 Enhances Pulmonary Clearance of<i>Pseudomonas aeruginosa</i> (1998)

To determine the effects of interleukin-4 (IL-4) on bacterial clearance from the mouse lung, transgenic mice expressing IL-4 in respiratory epithelial cells under the control of the Clara cell secretory protein promoter (CCSP-IL-4 mice) were infected intratracheally with Pseudomonas aeruginosa. Survival of CCSP-IL-4 mice following bacterial administration was markedly improved compared with that of control mice. While bacteria proliferated in lungs of wild-type mice, a rapid reduction in the number of bacteria was observed in the IL-4 mice as early as 6 h postinfection. Similarly, intranasal administration of IL-4 enhanced bacterial clearance from the lungs of wild-type mice. While acute and chronic IL-4 increased the numbers of neutrophils in bronchoalveolar lavage fluid, bacterial infection was associated with acute neutrophilic pulmonary infiltration, and this response was similar in the presence or absence of IL-4. Local administration or expression of IL-4 in the mouse lung enhanced pulmonary clearance of P. aeruginosa in vivo and decreased mortality following infection.
A Review and some Studies of the Effect of Sulfur on the Formation of Off-Odors in Wine (1962)

Sulfur dioxide in excess of 100 ppm in fermenting media may cause hydrogen sulfide off-odors. Elemental sulfur, as low as 5 ppm, will definitely provide residual hydrogen sulfide at the end of fermentation. Pumping over and periodic aeration will minimize the danger of hydrogen sulfide. Most of the hydrogen sulfide formed during fermentation is lost to the atmosphere, and this is facilitated by the sweeping action of carbon dioxide. Slow, cold, anaerobic fermentations encourage residual hydrogen sulfide in the wine. Sulfur applications in the vineyards are responsible for the presence of elemental sulfur in grape juices; but in wineries where the burning of sulfur wicks in barrels and tanks is still practiced, this will be another source of elemental sulfur which is chemically reduced to hydrogen sulfide during fermentation. From this investigation it appears that the grower, especially in the coast counties, should avoid sulfuring very late in the season.
Orthogonal 3D-SLAM for indoor environments using right angle corners (2007)

Soon, in many service robotic applications, a realtime localization and 3D-mapping capability will be necessary for autonomous navigation.Toward a light and practical SLAM algorithm for indoor scenarios, we propose a fast SLAM algorithm which benefits from sensor geometry for feature extraction and enhance the mapping process using dominant orthogonality in the engineered structures of man-made environments.Range images obtained using a nodding SICK are segmented into planar patches with polygonal boundaries in linear time.Right corner features are constructed based on the recognized orthogonal planes and used for robot localization.In addition to these corners, the map also contains planar patches with inner and outer boundaries for 3D modeling and recognition of the major building structures.Experiments using a mobile robot in our laboratory hallway prove the effectiveness of our approach.Results of the algorithm are compared with hand-measured ground truth.
Exact and Heuristic Scheduling Algorithms for Multiple Earth Observation Satellites Under Uncertainties of Clouds (2018)

Most earth observation satellites are equipped with optical sensors, which cannot see through clouds. Hence, many observations will be useless due to the presence of clouds. In this paper, we study the scheduling problem of multiple EOSs under uncertainties of clouds. In order to improve the possibility of completing tasks, we take the scheduling of each task to multiple resources (orbits) into account and establish a novel nonlinear mathematical model. To solve the problem efficiently, an exact algorithm based on enumeration is proposed, in which each subproblem is solved by path programming, and all the feasible solutions of subproblems are combined to solve the master problem. Furthermore, three heuristics are designed to solve the large-scale problems. From the experimental results on random samples, it is observed that the solutions of our model perform better than those of the previous studies. Besides, both our exact algorithm and a mixed-integer nonlinear programming solver-Couenne can solve our model optimally for small problems, but our algorithm is more efficient than Couenne. For large-scale problems, we reveal the strengths and weaknesses of the proposed heuristic algorithms while solving different instances of various sizes.
Blind beamforming in frequency division duplex MISO systems based on time reversal mirrors (2005)

We propose a novel method for both downlink (DL) and uplink (UL) blind channel estimation and beamforming in frequency division duplex (FDD) MISO (multiple-input single-output) antenna systems. The method is related to the concept of time reversal mirrors (TRMs). The TRM is applied so that the subscriber unit (SU) uses the UL channel "doubly", and thus there is no transmission overhead. The method's performance is close to that of optimal beamforming. With four antennas at the base station (BS) there is a gain in the range of 2-3 dB relative to a typical space-time block coder without feedback.
Reactions of Amines with Urea and its Derivatives. III (1962)

Diamines having no substituent group on the nitrogen are primary amines andthose having substituent group are secondary amines. Accordingly, the reaction of diamine and urea can easily be assumed from the reactions of primary amine and urea, and secondary amine and urea. In the reaction of aliphatic diamine and urea, a monosubstituent of urea was obtained almost selectively. Since the disubstituent is very difficult for its formation, a monourea and diurea derivatives of diamine are formed at first, followed by the reaction for formation of disubstituents or polymerization reaction. Also, some of aliphatic diamines form a cyclic compound from the reaction with urea. In this case, the cyclic compound is f romed through the process of formation of high polymer and its depolymerization. In the reaction of aromatic diamine and urea, there are the reactions of formation of a monosubstituent of urea at first, followed by the formation of its disubstituent; in this case, polymerization reaction happens at the same time of formation of monosubstituent of urea. The reaction of secondary diamine and urea gives no polymerization productas it is clear from its reaction mechanism.
A Versatile and Practical Synthesis toward the Development of Novel HIV‐1 Integrase Inhibitors (2011)

As a continuation of our previous work, which resulted in the identification of a new hit compound as an HIV-1 integrase inhibitor, three novel series of salicylic acid derivatives were synthesized using three versatile and practical synthetic strategies and were assayed for their capacity to inhibit the catalytic activity of HIV-1 integrase. Biological evaluations revealed that some of the synthesized compounds possess good inhibitory potency in enzymatic assays and are able to inhibit viral replication in MT-4 cells at low micromolar concentrations. Finally, docking studies were conducted to analyze the binding mode of the synthesized compounds within the DNA binding site of integrase in order to refine their structure-activity relationships.
Implementation and evaluation of dual stack mobile IPv6 (2007)

Abstract. Dual Stack Mobile IPv6 (DSMIPv6) is an extension of Mobile IPv6 to support IPv4 care-of address and to carry IPv4 traffic via bi-directional tunnels between mobile nodes and their home agents. Using DSMIPv6, mobile nodes only need the Mobile IPv6 protocol to manage mobility while moving within both the IPv4 and IPv6 Internet. This is an important feature for IPv6 mobility during its deployment phase because IPv6 access network is not widely deployed yet. This paper describes the DSMIPv6 implementation on BSD operating systems and presents results of the experiments using the implementation. 1
Separation of Two Functional Roles of <scp>l</scp> -Alanine in the Initiation of <i>Bacillus subtilis</i> Spore Germination (1967)

Spores of the standard transformable Marburg strain of Bacillus subtilis can be initiated to germinate by l-alanine alone. We isolated mutants which required for this process, in addition to l-alanine, the combination of d-glucose + d-fructose + K(+) or NH(4) (+) ions. In place of fructose, autoclaved or caramelized glucose could be used. Even the standard type strain required the addition of these three agents when d-alanine was present or when the temperature was raised. These findings show that l-alanine normally performs two functions during initiation, one of which is absent in the mutants or is blocked by d-alanine or elevated temperature. One of our mutants was not absolutely dependent on the addition of external l-alanine, because it could be initiated at a reduced rate by the sole addition of glucose + K(+) or NH(4) (+). When K(+) or NH(4) (+) was replaced by Na(+), the initiation rate was greatly reduced. The divalent metal ions Mg(++), Mn(++), and Ca(++) could not satisfy the cation requirement.
The synthesis of (±)-xanthorrhoein (1966)

(±)-Xanthorrhoein has been synthesised from 3-hydroxynaphthalic anhydride in ten steps. It melts at a higher temperature than (+)-xanthorrhoein, but its infrared, ultraviolet, and proton magnetic resonance spectra are identical with those of the natural product.
Study of the Dendritic Growth of NiCo Alloy Powders Electrodeposited on Cu Substrates (2009)

Abstract not Available.
Delayed Maturation of Neuronal Architecture and Synaptogenesis in Cerebral Cortex of<i>Mecp2</i>-Deficient Mice (2005)

We detected morphologic abnormalities in the cerebral cortex of Mecp2-hemizygous (Mecp2(-/y)) mice. The cortical thickness of both somatosensory and motor cortices in mutants did not increase after 4 weeks of age, as compared with that in wild-type male mice. The density of neurons in those areas was significantly higher in layers II/III and V of Mecp2(-/y) mice than in wild-type mice, particularly in layers II/ III after 4 weeks of age. In layer II/III of the somatosensory cortex of Mecp2(-/y) mice, the diameter of the apical dendrite was thin and the number of dendritic spines was small. Electron microscopy revealed that two-week-old mutants already had numerous premature postsynaptic densities. These results indicate that Mecp2(-/y) mice suffered delayed neuronal maturation of the cerebral cortex and that the initial neuronal changes were caused by premature synaptogenesis. Rett syndrome patients with a heterozygous mutation of Mecp2 display developmental disorders including cortical malfunctions such as mental retardation, autism, and epilepsy. Our results provide evidence of the similarity with Rett syndrome brains in some respects and suggest that MeCP2/Mecp2 plays some role in synaptogenesis.
Universal Pin Electronics in portable testers (2003)

The advantages of using a tester-per-pin concept in portable test stations are examined. These include: improved throughput, reduced tester size and power requirements, broadside test functions, multiport testing and reduced costs. Methods of extending digital and analog test frequencies to 75 MHz and of generating highly accurate clock subsystems are examined, along with unit-under-test (UUT) interface design considerations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hold-period accelerated cooling experiments on Nb- and Ti-HSLA steels (1977)

High-volume water sprays and air-water mixtures have been used to shorten the holdperiod(HP) in the two-stage rolling of 0.08%Nb, 0.02%Nb, and 0.09%Ti steels. The effects of gentler diffuse sprays were also roughly determined. Highvolume sprays create pronounced temperature gradients through the thickness, and subsequent rolling can produce deformed, elongated surface grains in the finished plate, depending upon steel composition, plate thickness during the HP, and spraying time. It appears that the lesser temperature gradients imposed by air-water mixtures or gentler diffuse sprays are better suited to significantly lower hold times for thick plates with larger additions of Nb or Ti. High-volume sprays can, however, be used to lower finishing temperatures in two-stage rolling in plain C-Mn (0.18C-1.28Mn) steel if adequate time is allowed after spraying to permit temperature homogenization through the thickness. The bulk mechanical properties of the HSLA steels tested were relatively unaffected by length of HP, and the 0.02%Nb steel improved markedly in strength and toughness on being oil quenched after rolling.
ChemInform Abstract: CHLORIDE, ‐HYDRIDE AND ‐BOROHYDRIDE DERIVATIVES OF DIFLUORENYL THALLIUM(III) (1975)

Abstract Das Na‐Salz von Fluoren reagiert mit Dipyridiniumpentachlorothallat in THF zu dem Derivat (Ia), das durch Na‐hydridoborat zu (Ib) umgesetzt wird.
Antiinflammatory and Immunomodulating Properties of FungalMetabolites (2005)

We discuss current information on the ability of extracts and isolated metabolites from mushrooms to modulate immune responses. This can result in a more enhanced innate and acquired disease resistance. The major immunomodulating effects of these active substances derived from mushrooms include mitogenicity and activation of immune effector cells, such as lymphocytes, macrophages, and natural killer cells, resulting in the production of cytokines, including interleukins (ILs), tumor necrosis factor alpha (TNF)-alpha, and interferon gamma (INF)-gamma. In particular, the ability of selective mushroom extracts to modulate the differentiation capacity of CD4(+) T cells to mature into T(H)1 and/or T(H)2 subsets will be discussed. As a consequence these extracts will have profound effects in particular diseases, like chronic autoimmune T(H)1-mediated or allergic T(H)2-mediated diseases. Immunosuppressive effects by mushroom components have also been observed. The therapeutic effects of mushrooms, such as anticancer activity, suppression of autoimmune diseases, and allergy have been associated with their immunomodulating effects. However, further studies are needed to determine the molecular mechanisms of the immunomodulating effects of mushrooms metabolites both individually and in complex mixtures, for example, extracts.
Image‐guided blended neighbor interpolation of scattered data (2009)

Uniformly sampled images are often used to interpolate other data acquired more sparsely with an entirely different mode of measurement. For example, downhole tools enable geophysical properties to be measured with high precision near boreholes that are scattered spatially, and less precise seismic images acquired at the earth's surface are used to interpolate those properties at locations far away from the boreholes. Image‐guided interpolation is designed specifically to enhance this process. Most existing methods for interpolation require distances from points where data will be interpolated to nearby points where data are known. Image‐guided interpolation requires non‐Euclidean distances in metric tensor fields that represent the coherence, orientations and shapes of features in images. This requirement leads to a new method for interpolating scattered data that I call blended neighbor interpolation. For simple Euclidean distances, blended neighbor interpolation resembles the classic natural neighbor interpolation.