gebhart/patrepeval huggingface dataset:
Dynamic Reconfiguration of Real-Time Network Interfaces (2005)

The programmable resources of reconfigurable computing architectures are commonly used to support application specific processing. Dynamic reconfiguration enables hardware adaptation even during run-time. This paper concentrates on extending the application of dynamically reconfigurable logic to the area of network interface logic. The benefits and consequences of implementing even low-level networking functions in programmable hardware over fixed realizations are explained, and the possibilities arising from reconfigurable network interfaces are shown. Concerning reconfiguration of the network interface subsystem at run-time, maintaining connections, preventing packet loss, and guaranteeing response times during reconfiguration is crucial. Methods for dynamically replacing network interface hardware are described, and the current prototype is shown.
Mycobacterium abscessus Glycopeptidolipid Prevents Respiratory Epithelial TLR2 Signaling as Measured by HβD2 Gene Expression and IL-8 Release (2011)

Mycobacterium abscessus has emerged as an important cause of lung infection, particularly in patients with bronchiectasis. Innate immune responses must be highly effective at preventing infection with M. abscessus because it is a ubiquitous environmental saprophyte and normal hosts are not commonly infected. M. abscessus exists as either a glycopeptidolipid (GPL) expressing variant (smooth phenotype) in which GPL masks underlying bioactive cell wall lipids, or as a variant lacking GPL which is immunostimulatory and invasive in macrophage infection models. Respiratory epithelium has been increasingly recognized as playing an important role in the innate immune response to pulmonary pathogens. Respiratory epithelial cells express toll-like receptors (TLRs) which mediate the innate immune response to pulmonary pathogens. Both interleukin-8 (IL-8) and human β-defensin 2 (HβD2) are expressed by respiratory epithelial cells in response to toll-like receptor 2 (TLR2) receptor stimulation. In this study, we demonstrate that respiratory epithelial cells respond to M. abscessus variants lacking GPL with expression of IL-8 and HβD2. Furthermore, we demonstrate that this interaction is mediated through TLR2. Conversely, M. abscessus expressing GPL does not stimulate expression of IL-8 or HβD2 by respiratory epithelial cells which is consistent with "masking" of underlying bioactive cell wall lipids by GPL. Because GPL-expressing smooth variants are the predominant phenotype existing in the environment, this provides an explanation whereby initial M. abscessus colonization of abnormal lung airways escapes detection by the innate immune system.
Nitric oxide signaling in ischemic heart (1995)

The results suggest for the first time that NO plays a significant role in transmembrane signaling in the ischemic myocardium. The signaling seems to be transmitted via cGMP and opposes the effects of phosphodiesterases by inhibiting the ischemia/reperfusion-induced phosphodiesteratic breakdown. This signaling effect appears to be reduced as reperfusion progresses. These results, when viewed in the light of free radical chemistry of NO, suggest that such on- and off-signaling of NO may be linked to its interaction with the superoxide radical generated during the reperfusion of ischemic myocardium.
A comparison of three commercially available antiseptics against opportunist gram-negative pathogens. (1976)

Two test methods, a skin replica test and the Kelsey Sykes test have been used to compare the efficacy of three antiseptics against three Gram-negative micro-organisms in an attempt to select the most suitable. The results of both tests showed that an antiseptic containing added ethylenediaminetetraacetic acid was superior to the other two. The skin test showed that this superiority was apparent in both the immediate and the persistant bactericidal activity of the antiseptic towards all three Gram-negative micro-organisms.
A New Monoterpene from the Leaves of a Radiation Mutant Cultivar of Perilla frutescens var. crispa with Inhibitory Activity on LPS-Induced NO Production (2017)

The leaves of <i>Perilla frutescens</i> var. <i>crispa</i> (Lamiaceae)-known as 'Jureum-soyeop' or 'Cha-jo-ki' in Korean, 'ZI SU YE' in Chinese, and 'Shiso' in Japan-has been used as a medicinal herb. Recent gamma irradiated mutation breeding on <i>P. frutescens</i> var. <i>crispa</i> in our research group resulted in the development of a new perilla cultivar, <i>P. frutescens</i> var. <i>crispa</i> (cv. Antisperill; PFCA), which has a higher content of isoegomaketone. The leaves of PFCA were extracted by supercritical carbon dioxide (SC-CO₂) extraction, and phytochemical investigation on this extract led to the isolation and identification of a new compound, 9-hydroxy-isoegomaketone [(2<i>E</i>)-1-(3-furanyl)-4-hydroxy-4-methyl-2-penten-1-one; <b>1</b>]. Compound <b>1</b> exhibited inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 cells with an IC<sub>50</sub> value of 14.4 μM. The compounds in the SC-CO₂ extracts of the radiation mutant cultivar and the original plant were quantified by high-performance liquid chromatography with diode array detection.
Using a randomized path planner to generate 3D task demonstrations of robot operations (2010)

In this paper we describe a new randomized path-planning approach presenting two novel features that are useful in various complex real-world applications. First, it handles zones in the robot workspace with different degrees of desirability. Given the random quality of paths that are calculated by traditional randomized approaches, this provides a mean to specify a sampling strategy that controls the search process to generate better paths by simply annotating regions in the free workspace with degrees of desirability. Second, our approach can efficiently re-compute paths in dynamic environments where obstacles and zones can change shape or move concurrently with the robot. The new path planner is implemented within an automated planning application for generating 3D tasks demonstrations involving a teleoperated robot arm on the International Space Station (ISS). A typical task demonstration involves moving the robot arm from one configuration to another. Our objective is to automatically plan the position of cameras to film the arm in a manner that conveys the best awareness of the robot trajectory to the user. For a given task, the robot trajectory is generated using the new path planner. The latter not only computes collision free paths but also takes into account the limited direct view of the ISS, the lighting conditions and other safety constraints about operating the robot. A suitable camera planning system is then used to find the best sequence of camera shots following the robot on its path.
Unsupervised extraction of template structure in web search queries (2012)

Web search queries are an encoding of the user's search intent and extracting structured information from them can facilitate central search engine operations like improving the ranking of search results and advertisements. Not surprisingly, this area has attracted a lot of attention in the research community in the last few years. The problem is, however, made challenging by the fact that search queries tend to be extremely succinct; a condensation of user search needs to the bare-minimum set of keywords. In this paper we consider the problem of extracting, with no manual intervention, the hidden structure behind the observed search queries in a domain: the origins of the constituent keywords as well as the manner the individual keywords are assembled together. We formalize important properties of the problem and then give a principled solution based on generative models that satisfies these properties. Using manually labeled data we show that the query templates extracted by our solution are superior to those discovered by strong baseline methods.
Reading canonical and modified nucleobases in 16S ribosomal RNA using nanopore native RNA sequencing (2019)

The ribosome small subunit is expressed in all living cells. It performs numerous essential functions during translation, including formation of the initiation complex and proofreading of base-pairs between mRNA codons and tRNA anticodons. The core constituent of the small ribosomal subunit is a ~1.5 kb RNA strand in prokaryotes (16S rRNA) and a homologous ~1.8 kb RNA strand in eukaryotes (18S rRNA). Traditional sequencing-by-synthesis (SBS) of rRNA genes or rRNA cDNA copies has achieved wide use as a 'molecular chronometer' for phylogenetic studies, and as a tool for identifying infectious organisms in the clinic. However, epigenetic modifications on rRNA are erased by SBS methods. Here we describe direct MinION nanopore sequencing of individual, full-length 16S rRNA absent reverse transcription or amplification. As little as 5 picograms (~10 attomole) of purified E. coli 16S rRNA was detected in 4.5 micrograms of total human RNA. Nanopore ionic current traces that deviated from canonical patterns revealed conserved E. coli 16S rRNA 7-methylguanosine and pseudouridine modifications, and a 7-methylguanosine modification that confers aminoglycoside resistance to some pathological E. coli strains.
Antitumor Drug Delivery by Dextran Derivatives Immobilizing Platinum Complex (II) Through Coordination Bond (1998)

cis-Dichloro(cyclohexane-trans-l-1,2-diamine)platinum (II): Dach-Pt(chlorato) is a platinum complex which is expected to exhibit higher antitumor activity than typical antitumoral platinum complexes. However, its strong side-effects and low water-solubility have been noted. We have reported that polymer/antitumor drug conjugates showed reduced side-effects and high antitumor activity. In order to provide a macromolecular prodrug of Dach-Pt having reduced side-effects and high water-solubility, we synthesized polymer conjugate of Dach-Pt by immobilizing Dach-Pt via a chelate-type coordination bond to dextran derivatives containing dicarboxylic acid groups, oxidized-dextran(OX-dextran)/Dach-Pt conjugate and dicarboxymethyl-dextran(DCM-Dex)/Dach-Pt conjugate. We investigated the release behavior of the platinum complex from the conjugates and the cytotoxic activity of the conjugates against p388D1lymphocytic leukemia cells in vitro compared with the carboxymethyl-dextran(CM-Dex)/Dach-Pt conjugate. The conjugates showed almost the same level of cytotoxic activity as free Dach-Pt(chlorato) or Dach-Pt(malonato). Although the cytotoxic activity of free Dach-Pt(chlorato) was decreased by incubation in a medium with serum, the conjugates kept their cytotoxic activity in higher level after certain period of incubation in a medium with serum. Moreover, we investigated in vivo antitumor activity of OX-Dex/Dach-Pt conjugate against colon 26 tumor bearing mice. The conjugate showed effective growth inhibitory effect against tumor cells.
Reflected optical harmonics from dielectric mirrors (1994)

Optical second and third harmonics were generated in reflection from commercially available laser dielectric mirrors. Although most dielectric coatings on laser mirrors are centrosymmetric, the inversion symmetry is broken at the dielectric-air interface. When intense femtosecond laser pulses are reflected off the dielectric mirrors, a second-order dipole contribution to surface second-harmonic generation can exist and is detected. More dramatically, at a laser fluence of ∼10 GW/cm(2) the normally much weaker electric-dipole-allowed third-harmonic generation that originated in the bulk accentuates the second-harmonic generation. These reflected harmonics are, in some cases, nonnegligible in many sensitive experiments.
Phytochemicals and Antioxidant Properties in Wheat Bran (2004)

Bran samples of seven wheat varieties from four different countries were examined and compared for their phytochemical compositions and antioxidant activities. Phenolic acid composition, tocopherol content, carotenoid profile, and total phenolic content were examined for the phytochemical composition of wheat bran, whereas the measured antioxidant activities were free radical scavenging properties against 2,2-diphenyl-1-picrylhydrazyl radical, radical cation 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, peroxide radical anion O(2)(.-), and oxygen radical and chelating capacities. The results showed that the tested wheat bran samples differed in their phytochemical compositions and antioxidant properties. Ferulic acid, with a concentration range of 99-231 microg/g, was the predominant phenolic acid in all of the tested bran samples and accounted for about 46-67% of total phenolic acids on a weight basis. The concentrations for alpha-, delta-, and gamma- tocopherols were 1.28-21.29, 0.23-7.0, and 0.92-6.90 microg/g, respectively. In addition, lutein and cryptoxanthin were detected in all of the tested bran samples with levels of 0.50-1.80 and 0.18-0.64 microg/g, respectively. Zeaxanthin was detected in the six bran samples, and the greatest zeaxanthin concentration of 2.19 microg/g was observed in the Australian general purpose wheat bran. Beta-carotene was detected in four of the tested bran samples at a range of 0.09-0.40 microg/g. These data suggest that wheat and wheat bran from different countries may differ in their potentials for serving as dietary sources of natural antioxidants.
BeadArray <sup>™</sup> Technology: Enabling an Accurate, Cost-Effective Approach to High-Throughput Genotyping (2002)

The Human Genome Project has opened the door to personalized medicine, provided that human genetic diversity can be analyzed in a high-throughput and cost-effective way Illumina has developed a genotyping system that combines very high throughput and accuracy with low cost per SNP analysis. The system uses our BeadArray platform, a high level of multiplexing, and modular, scalable automation to meet the requirements for cost-effective, genome-wide linkage disequilibrium studies. As implemented in a high-throughput genotyping service facility at Illumina, the system has a current capacity of one million SNP assays per day and is easily expandable. Each SNP call is associated with a quality score that correlates with accuracy
IOP-Induced Lamina Cribrosa Displacement and Scleral Canal Expansion: An Analysis of Factor Interactions Using Parameterized Eye-Specific Models (2010)

IOP-related LCD and SCE result from a complex combination of factors, including geometry and material properties of the LC and sclera. This work lays the foundation for interpreting the range of individual sensitivities to IOP and illustrates that predicting individual ONH response to IOP will require the measurement of multiple factors.
The effect of rubber particle size on the mechanical properties of high-impact polystyrene (1978)

Resins having different rubber particle sizes were prepared by polymerizing impact polystyrene using different agitation rates but keeping all other parameters constant. Also, samples were made varying the amount and type of rubber and type of agitation. The impact and tensile properties of the prepared resins are studied in relation to existing theories of rubber particle reinforcement. The particle size dependence of energy absorption in impact (high intensity) and tensile (low intensity) testing appear to be opposite in nature. Energy absorption increases with increasing particle size in the high-intensity mode and decreases in low-intensity testing. Different mechanisms are, therefore, postulated to be operative in each of these two test methods.
Antibody-Drug Conjugates: Where the Action Is: ADCs - The New Frontier. (2012)

Next generation antibody-drug conjugates, like T-DM1, are meant to kill the cancer - not the patient.
A molecularly imprinted nanocavity-based fluorescence polarization assay platform for cortisol sensing (2016)

We prepared core-shell-type molecularly imprinted polymer particles (MIP-NPs) for cortisol using cortisol-21-monomethacrylate as a template molecule, itaconic acid as an additional functional monomer, styrene as a comonomer and divinylbenzene as a crosslinker, and established a fluorescence polarization-based sensing nano-platform for the competitive binding assay of cortisol using dansyl-labeled cortisol (dansyl-cortisol). Before the preparation of MIP-NPs, the binding behavior of bulk MIPs prepared by conventional radical polymerization was preliminarily characterized. NIPs prepared with methacrylic acid instead of cortisol-21-monomethacrylate showed less binding activity than the MIPs, revealing that the molecular imprinting process enhanced the affinity toward cortisol. Since the imprinting effect was confirmed in this system, the fluorescence polarization-based sensing nano-platform for cortisol was constructed using MIP-NPs with dansyl-cortisol, where the binding event of cortisol was transduced into the fluorescence anisotropy change of dansyl-cortisol from the bound-state to the free-state, on the basis of the concentration-dependent competitive replacement of dansyl-cortisol by cortisol added on MIP-NPs. The complex of MIP-NPs with dansyl-cortisol was more effectively formed than that of the reference polymer particles (R-MIP-NPs) prepared without itaconic acid, suggesting that the itaconic acid and cortisol-21-monomethacrylate-derived methacrylic acid residues can work cooperatively. Highly sensitive cortisol detection was achieved by the proposed molecularly imprinted nanocavity-based fluorescence polarization assay for cortisol sensing with dansyl-cortisol, and the apparent limit of detection was estimated to be ca. 80 nM.
Peer Reviewed: FTIR Images (2001)

ADVERTISEMENT RETURN TO ISSUEPREVFeatureNEXTPeer Reviewed: FTIR ImagesA new technique produces images worth a thousand spectra.Jack L. Koenig, Shi-Qing Wang, and Rohit BhargavaCite this: Anal. Chem. 2001, 73, 13, 360 A–369 APublication Date (Web):July 1, 2001Publication History Published online1 July 2001Published inissue 1 July 2001https://pubs.acs.org/doi/10.1021/ac012471phttps://doi.org/10.1021/ac012471pnewsACS Publications. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1894Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (102 MB) Get e-Alertsclose SUBJECTS:Fourier transform infrared spectroscopy Get e-Alerts
The magnetization reversal process in amorphous wires (1995)

The most outstanding property of amorphous wires is their capability to magnetized through a single Barkhausen jump giving rise to squared hysteresis loop. This phenomenon is spontaneously shown in large magnetostriction wires in the as-quenched state. According to the previous model, such a Barkhausen jump arises from the magnetization reversal inside core having axial easy magnetization axis. In this work, we review some recent results leading to a refinement of the previous model paying particular attention to the domain structure close to wires having different lengths. The existence of "closure" domains in such regions and the ends of existence of their variation when applied fields up to a critical value for magnetization reversal process. To deepen the knowledge of the dynamics of the wall responsible for the magnetization two experimental studies were performed namely, the conventional Sixtus-Tonks experiment and the magnetization reversal under homogeneous applied field along the sample. The main conclusions are: (a) the reversal process is spontaneously initiated close to the end of the wire where the wall is depinned and propagates along the entire wire, (b) the starting end alternates in each reversal or remains the same depending on an additional external applied field, and (c) the wall during the reversal approaches a planar shape.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A histomorphological study of tendon reconstruction to a hydroxyapatite‐coated implant: Regeneration of a neo‐enthesis in vivo (2004)

The attachment of tendons and ligaments to massive endoprostheses remains a clinical challenge due to the difficulty in achieving a soft tissue implant interface with a mechanical strength sufficient to transmit the forces necessary for locomotion. We have used an in vivo animal model to study patellar tendon attachment to an implant surface. The interface generated when the patellar tendon was attached to a hydroxyapatite (HA) coated implant was examined using light microscopy and a quantitative histomorphological analysis was performed. In the Autograft Group, the interface was augmented with autogenous cancellous bone and marrow graft, and at six weeks an indirect-like insertion was observed. At twelve weeks, the interface was observed to be a layered neo-enthesis, whose morphology was similar to a normal direct tendon insertion. In the HA Group, the tendon-implant interface was not augmented, and the implant was enveloped by a dense collagenous fibrous tissue. This study shows that a tendon-implant neo-enthesis can develop in situ by employing a suitable implant surface in association with biological augmentation.