gebhart/patrepeval huggingface dataset:
Acetaminophen-mediated cardioprotection via inhibition of the mitochondrial permeability transition pore-induced apoptotic pathway (2007)

Our laboratory has previously reported that acetaminophen confers functional cardioprotection following cardiac insult, including ischemia/reperfusion, hypoxia/reoxygenation, and exogenous peroxynitrite administration. In the present study, we further examined the mechanism of acetaminophen-mediated cardioprotection following ischemia/reperfusion injury. Langendorff-perfused guinea pig hearts were exposed to acute treatment with acetaminophen (0.35 mM) or vehicle beginning at 15 min of a 30-min baseline stabilization period. Low-flow global myocardial ischemia was subsequently induced for 30 min followed by 60 min of reperfusion. At the completion of reperfusion, hearts were homogenized and separated into cytosolic and mitochondrial fractions. Mitochondrial swelling and mitochondrial cytochromec release were assessed and found to be significantly and completely reduced in acetaminophen- vs. vehicle-treated hearts following reperfusion. In a separate group of hearts, ventricular myocytes were isolated and subjected to fluorescence-activated cell sorting. Acetaminophen-treated hearts showed a significant decrease in late stage apoptotic myocytes compared with vehicle-treated hearts following injury (58 +/- 1 vs. 81 +/- 5%, respectively). These data, together with electron micrograph analysis, suggest that acetaminophen mediates cardioprotection, in part, via inhibition of the mitochondrial permeability transition pore and subsequent apoptotic pathway.
5-Benzoyl-4-hydroxy-6-(4-nitrophenyl)-4-trifluoromethyl-3,4,5,6-tetrahydropyrimidin-2(1<i>H</i>)-one monohydrate (2008)

The asymmetric unit of the title compound, C(18)H(14)F(3)N(3)O(5)·H(2)O, contains two independent formula units. The two heterocyclic mol-ecules differ in the orientations of the benzoyl-phenyl group with respect to the tetra-hydro-pyrimidine ring [C-C-C-C torsion angles of 64.5 (3) and 67.1 (3)°]. In both mol-ecules the pyrimidine ring adopts a half-chair conformation. The mol-ecules are linked into a two-dimensional network parallel to (001) by N-H⋯O and O-H⋯O hydrogen bonds.
Bayes-Ball: The Rational Pastime (for Determining Irrelevance and Requisite Information in Belief Networks and Influence Diagrams) (2013)

One of the benefits of belief networks and influence diagrams is that so much knowledge is captured in the graphical structure. In particular, statements of conditional irrelevance (or independence) can be verified in time linear in the size of the graph. To resolve a particular inference query or decision problem, only some of the possible states and probability distributions must be specified, the "requisite information." This paper presents a new, simple, and efficient "Bayes-ball" algorithm which is well-suited to both new students of belief networks and state of the art implementations. The Bayes-ball algorithm determines irrelevant sets and requisite information more efficiently than existing methods, and is linear in the size of the graph for belief networks and influence diagrams.
A comparison of different orbivirus proteins that could affect virulence and pathogenesis. (2010)

The factors that determine the virulence and pathogenesis characteristics of bluetongue virus (BTV), African horse sickness virus (AHSV) and other orbiviruses are not well known. With respect to the viral proteins that are expected to play a role it may be assumed that proteins, such as the outer capsid proteins VP2 and VP5, that are involved in the attachment of virus particles to target cells and influence replication efficiency are particularly important. Equally important are viral proteins such as non-structural protein NS3 that influence the release of virus particles from a target host or vector cell. The authors compare the amino acid sequence variation, structural motifs and some phenotypic characteristics of proteins VP2, VP5 and NS3 of different orbiviruses, such as AHSV, BTV and equine encephalosis virus (EEV). The most variable protein is VP2 and a pair-wise alignment of VP2 sequences of different serotypes of both BTV and AHSV indicated variation of between 48% to 64% and 46% to 52% for most isolates, respectively. Several regions of high variability can be identified. VP5 of BTV is much less variable than VP2 but still more so than the cognate AHSV VP5. In contrast, the NS3 protein of AHSV is much more variable than its BTV or EEV counterpart with maximum levels of NS3 variation up to 36% as compared to 10% for BTV. The AHSV NS3 variation is clustered into three discreet phylogenetic groups. All orbivirus NS3/NS3A proteins share a number of highly conserved structural features that include two hydrophobic domains (HD1 and HD2) that are involved in the interaction with the membrane. Most of the NS3 variation is located in HD1 and the adjacent variable region between HD1 and HD2. In the case of AHSV this region only has 13% identity compared to 64% in the case of BTV. NS3 of AHSV is also a highly toxic protein and mutation analysis has indicated that the toxicity is associated with the two hydrophobic domains. Expression of NS3 deletion mutants in bacterial cells has shown that both HD1 and HD2 are necessary for cytotoxicity and that removal of the adjacent N-terminal domains increases cytotoxicity. Preliminary results with different AHSV strains and the corresponding NS3 equivalent have indicated that the membrane permeabilisation effect of the individual NS3 proteins correlate with the permeabilisation effect of the corresponding viruses. These results would suggest that characterisation of the NS3 protein by itself might predict some phenotypic characteristics and potential membrane destabilisation effect of the corresponding virus.
Electrochemical and anticorrosion properties of 5-hydroxytryptophan on mild steel in a simulated well-acidizing fluid (2017)

The anticorrosion effect of 5-hydroxytryptophan (5-HTP) on mild steel (MS) was investigated by gravimetric and electrochemical techniques. Two different concentrations (1 M and 15%) of hydrochloric acid were used to simulate well-acidizing fluid. The results show that 10 × 10−5 M 5-HTP is 96.1% efficient in 1 M HCl and 78.1% efficient in 15% HCl at 30 °C. The efficiency decreases as the temperature increases, reaching 66.9% and 39.8% in 1 M and 15% HCl, respectively, at 90 °C. When 5-HTP is blended with potassium iodide and glutathione, the efficiency increases to above 88% and 78% in 1 M and 15% HCl, respectively, at 90 °C. Increasing the 5-HTP concentration decreases the double-layer capacitance and increases the charge-transfer resistance. 5-HTP behaves as a mixed‐type corrosion inhibitor with anodic predominance and is spontaneously adsorbed on the steel surface. Physisorption of 5-HTP is best described by the Langmuir adsorption model and is also exothermic with a resultant decrease in the entropy of the bulk solution. The results of SEM/EDAX, FTIR and UV–VIS studies support the hypothesis that a protective film of 5-HTP forms on MS facilitated by O, N and CC functionalities.
Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C (1990)

The ability of tumor-promoting phorbol diesters to inhibit both insulin receptor tyrosine kinase activity and its intracellular signaling correlates with the phosphorylation of the insulin receptor beta subunit on serine and threonine residues. In the present studies, mouse 3T3 fibroblasts transfected with a human insulin receptor cDNA and expressing greater than one million of these receptors per cell were labeled with [32P]phosphate and treated with or without 100 nM 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA). Phosphorylated insulin receptors were immunoprecipitated and digested with trypsin. Alternatively, insulin receptors affinity purified from human term placenta were phosphorylated by protein kinase C prior to trypsin digestion of the 32P-labeled beta subunit. Analysis of the tryptic phosphopeptides from both the in vivo and in vitro labeled receptors by reversed-phase HPLC and two-dimensional thin-layer separation revealed that PMA and protein kinase C enhanced the phosphorylation of a peptide with identical chromatographic properties. Partial hydrolysis and radiosequence analysis of the phosphopeptide derived from insulin receptor phosphorylated by protein kinase C indicated that the phosphorylation of this tryptic peptide occurred specifically on a threonine, three amino acids from the amino terminus of the tryptic fragment. Comparison of these data with the known, deduced receptor sequence suggested that the receptor-derived tryptic phosphopeptide might be Ile-Leu-Thr(P)-Leu-Pro-Arg. Comigration of a phosphorylated synthetic peptide containing this sequence with the receptor-derived phosphopeptide confirmed the identity of the tryptic fragment. The phosphorylation site corresponds to threonine 1336 in the human insulin receptor beta subunit.(ABSTRACT TRUNCATED AT 250 WORDS)
Horseradish Peroxidase-Driven fluorescent Labeling of Nanotubes with Quantum Dots (2006)

We describe the first enzyme-driven technique for fluorescent labeling of single-walled carbon nanotubes (SWNTs). The labeling was performed via enzymatic biotinylation of nanotubes in the tyramide-horseradish peroxidase (HRP) reaction. Both direct and indirect fuorescent labeling of SWNTs was achieved using either biotinyl tyramide or fluorescently tagged tyramides. Biotinylated SWNTs later reacted with streptavidin-conjugated fluorophores. Linking semiconductor nanocrystals, quantum dots (Q-dots), to the surface of nanotubes resulted in their fluorescent visualization, whereas conventional fluorophores bound to SWNTs directly or through biotin-streptavidin linkage, were completely quenched. Enzymatic biotinylation permits fluorescent visualization of carbon nanotubes, which could be useful for a number of biomedical applications. In addition, other organic molecules such as proteins, antibodies, or DNA can be conjugated to biotinylated SWNTs using this approach.
The Dialysis Outcomes and Practice Patterns Study (DOPPS): How Can We Improve the Care of Hemodialysis Patients? (2001)

Outcomes among dialysis patients vary considerably internationally and across regions within the United States. The Dialysis Outcomes and Practice Patterns Study (DOPPS) is a large, prospective, observational study of representative samples of hemodialysis patients in France, Germany, Italy, Japan, Spain, the United Kingdom, and the United States. The DOPPS collects a wealth of data regarding the patients' demographic characteristics, medical histories, laboratory values, prescriptions, dialysis unit practices, and outcomes. The study seeks to clarify which dialysis practices contribute to improved mortality rates, hospitalization rates, health related quality of life, and vascular access outcomes, after adjusting for the effects of comorbid disease and demographic variables. Over 18,000 patients have been enrolled to date. This paper describes the initial findings and outlines the plans to expand the trial.
Locally Adjusted Robust Regression for Human Age Estimation (2008)

Automatic human age estimation has considerable potential applications in human computer interaction and multimedia communication. However, the age estimation problem is challenging. We design a locally adjusted robust regressor (LARR) for learning and prediction of human ages. The novel approach reduces the age estimation errors significantly over all previous methods. Experiments on two aging databases show the success of the proposed method for human aging estimation.
Functional and Structural Insights of a Staphylococcus aureus Apoptotic-like Membrane Peptide from a Toxin-Antitoxin Module (2012)

We report a functional type I toxin-antitoxin (TA) module expressed by a human pathogen, Staphylococcus aureus. TA systems consist of stable toxins and labile antitoxins encoded within small genetic modules widespread in eubacteria and archaea. TA genes provide stress adaptation and protection against DNA loss or invasion. The genes encoding the SprA1 toxic peptide (PepA1) and the SprA1(AS) RNA antitoxin are within a pathogenicity island on opposite strands and possess a 3' overlap. To prevent peptide toxicity during S. aureus growth, PepA1 expression from stable (half-life > 3 h) SprA1 is repressed by elevated amounts of unstable (half-life = ∼10 mn) SprA1(AS). In vivo, PepA1 localizes at the bacterial membrane and triggers S. aureus death. Based on NMR and CD data, its solution structure was solved and is a long bent, interrupted helix. Molecular dynamics simulations indicate that PepA1 compaction and helical content fluctuate in accordance with its cytoplasm or membrane location. When inserted into the S. aureus membrane, the PepA1 conformation switches to a ∼7-nm-long continuous helix, presumably forming pores to alter membrane integrity. PepA1 expression is induced upon acidic and oxidative stresses by reducing SprA1(AS) levels. As an altruistic behavior during infection, some cells may induce the expression of that toxin that would facilitate departure from the host immune cells for spreading.
Evaluation of Capillary Pressure Methods via Digital Rock Simulations (2015)

Capillary pressure measurements are an important part of the characterization of petroleum-bearing reservoirs. Three commonly used laboratory techniques, namely the porous plate (PP), centrifuge multi-speed experiment (CM), and mercury intrusion (MICP) methods, often provide nonidentical capillary pressure curves. We use high-resolution -CT images of Fontainebleau and Bentheimer sandstones to derive saturation profiles numerically in 3D at the pore scale through morphological distance transforms to simulate the above experiments. In the invasion simulation, the capillary pressure is realized by using as structural element a ball-whose diameter is a function of a local pressure potential, which in turn is a function of radial distance in centrifuge experiment and constant throughout the sample in MICP and porous plate measurements. To assess the effect on heterogeneous rock samples, we compare the computed saturation profiles of the relatively homogeneous sandstones to a highly heterogeneous numerical model of rock generated by a mixture of a Gaussian random field approach for the large-scale features and two Poisson particle processes at the small scale. The comparison of the image-based pore-scale numerical interpretation to capillary drainage experiments reveals their match and demonstrates the influence of boundary conditions and heterogeneity on the resulting saturation profiles and capillary pressure curves. Simulated centrifuge experiments may assist in estimation of experimental equilibrium times and provide a useful tool in speed schedule design.
Embarrassment in Consumer Purchase: The Roles of Social Presence and Purchase Familiarity: Table 1 (2001)

Two field studies investigate the importance of social presence (real and imagined) and familiarity with the purchase act in producing embarrassment in the context of an embarrassing product purchase. The results indicate that awareness of a social presence during purchase selection and commitment, whether real or imagined, is a motivating factor in creating embarrassment for the consumer. Further, our results show that the more familiar consumers are with an embarrassing product purchase, the less embarrassed they are likely to feel. Familiarity with an embarrassing product purchase is also shown to have implications for the effect of social presence. That is, familiarity with purchase acts as a moderator for the relationship of real social presence and embarrassment by reducing the influence of the social presence. In the context of an imagined social presence, purchase familiarity is shown to reduce the likelihood of imagining. These findings are integrated into a discussion of the theoretical implications and the potential avenues for future research in the area. Copyright 2001 by the University of Chicago.
A new adaptive equalizer with a channel estimator for mobile radio communications (2002)

For unknown mobile radio channels with severe intersymbol interference (ISI), a maximum likelihood sequence estimator needs to handle both postcursors and precursors, like a decision feedback equalizer (DFE) having both linear and feedback filters. Consequently, such an equalizer is too complex to be practical. The paper presents the performance of a new reduced-state soft decision feedback Viterbi equalizer (RSSDFVE) and a modified reduced state sequence estimator(RSSE) with a channel estimator and predictor. Two profile Rayleigh fading channel models with a Doppler frequency shift are used in the simulation. In order to update the RSSDFVE and RSSE to track the changes of fading channels, different channel estimation techniques are discussed in this paper. The simulation results are compared with a recursive least square (RLS) decision feedback equalizer (DFE) and a maximum likelihood sequence estimator (MLSE).
Material effects on the performance and reliability of high-power molded dual-in-line packages (2003)

Materials used in the packaging of high-power-dissipation molded dual-in-line packages (MDIPs) are investigated. The selection of the correct materials is based on a finite-element stress-analysis (FESA) model. The FESA results, which are used to compare various materials and their properties, are substantiated by experimental results. Chip or die cracking due to thermal stresses within the package caused by soldering is the failure mechanism on which this study is based and which is used to judge package materials are judged. The specific material systems addressed are: leadframe composition and thickness, silicon chip thickness, and die attach composition and thickness.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Siglec-15 Regulates Osteoclast Differentiation by Modulating RANKL-Induced Phosphatidylinositol 3-Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12 (2013)

Abstract Siglecs are a family of sialic acid–binding immunoglobulin-like lectins that regulate the functions of cells in the innate and adaptive immune systems through glycan recognition. Here we show that Siglec-15 regulates osteoclast development and bone resorption by modulating receptor activator of nuclear factor κB ligand (RANKL) signaling in association with DNAX-activating protein 12 kDa (DAP12), an adaptor protein bearing an immunoreceptor tyrosine-based activation motif (ITAM). Among the known Siglecs expressed in myeloid lineage cells, only Siglec-15 was upregulated by RANKL in mouse primary bone marrow macrophages. Siglec-15–deficient mice exhibit mild osteopetrosis resulting from impaired osteoclast development. Consistently, cells lacking Siglec-15 exhibit defective osteoclast development and resorptive activity in vitro. RANKL-induced activation of phosphatidylinositol 3-kinase (PI3K)/Akt and Erk pathways were impaired in Siglec-15–deficient cells. Retroviral transduction of Siglec-15–null osteoclast precursors with wild-type Siglec-15 or mutant Siglec-15 revealed that the association of Siglec-15 with DAP12 is involved in the downstream signal transduction of RANK. Furthermore, we found that the ability of osteoclast formation is preserved in the region adjacent to the growth plate in Siglec-15–deficient mice, indicating that there is a compensatory mechanism for Siglec-15–mediated osteoclastogenesis in the primary spongiosa. To clarify the mechanism of this compensation, we examined whether osteoclast-associated receptor (OSCAR)/Fc receptor common γ (FcRγ) signaling, an alternative ITAM-mediated signaling pathway to DAP12, rescues impaired osteoclastogenesis in Siglec-15–deficient cells. The ligands in type II collagen activate OSCAR and rescue impaired osteoclastogenesis in Siglec-15–deficient cells when cultured on bone slices, indicating that Siglec-15–mediated signaling can be compensated for by signaling activated by type II collagen and other bone matrix components in the primary spongiosa. Our findings indicate that Siglec-15 plays an important role in physiologic bone remodeling by modulating RANKL signaling, especially in the secondary spongiosa. © 2013 American Society for Bone and Mineral Research.
Solution Thermodynamics from Gas-Liquid Chromatography. (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolution Thermodynamics from Gas-Liquid Chromatography.R. E. Pecsar and J. J. MartinCite this: Anal. Chem. 1966, 38, 12, 1661–1669Publication Date (Print):November 1, 1966Publication History Published online1 May 2002Published inissue 1 November 1966https://pubs.acs.org/doi/10.1021/ac60244a009https://doi.org/10.1021/ac60244a009research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ACTO TAURINO LITERARIO. EN SAN ILDEFONSO SE RINDIÓ HOMENAJE A MANOLETE, FIGURA LEGENDARIA DE LA FIESTA BRAVA (1997)

EN ANTIGUO COLEGIO DE SAN ILDEFONSO, LA PENA TAURINA UNIVERSITARIA AC ORGANIZO 28 DE AGOSTO UN ACTO TAURINO LITERARIO CON MOTIVO DEL CINCUENTENARIO DE LA MUERTE DE MANOLETE, RELEVANTE FIGURA DE LA FIESTA BRAVA. EN HOMENAJE CELEBRADO 28 DE AGOSTO PARTICIPARON LOS EMBAJADORES DE VENEZUELA, ESPANA Y ECUADOR, LOS PINTORES RAUL ANGUIANO Y MANUEL FELGUEREZ, ESCULTOR HUMBERTO PERAZA -QUIEN ESCULPIO UN BUSTO DE MANOLETE Y LO DEVELO EN FESTEJO, JUNTO CON ANGUIANO-, LOS ESCRITORES ALI CHUMACERO Y ARTURO AZUELA, Y LOS MATADORES DE TOROS ALFONSO EL CALESERO RAMIREZ Y MANOLO ARRUZA, ENTRE OTROS.
Ion Transport in Glassy Polymer Electrolytes (1999)

The existence is reported of a new class of polymer electrolytes, containing polyether backbones and pendent mesogenic groups. These are amorphous (and sometimes liquid crystalline) polymeric solids with sub-Tg conductivities approaching 10-5 S cm-1 at ambient temperatures. The apparent decoupling of ion transport from structural relaxations in the host material implies the existence of a truly “solid” polymer electrolyte, which also implies a link between ion-transport mechanisms in glasses and in polymeric materials. In future it should be possible to develop materials for a variety of electrochemical applications, based on this new design strategy.