gebhart/patrepeval huggingface dataset:
Calibration of Wi-Fi-Based Indoor Tracking Systems for Android-Based Smartphones (2019)

With the growing development of smartphones equipped with Wi-Fi technology and the need of inexpensive indoor location systems, many researchers are focusing their efforts on the development of Wi-Fi-based indoor localization methods. However, due to the difficulties in characterizing the Wi-Fi radio signal propagation in such environments, the development of universal indoor localization mechanisms is still an open issue. In this paper, we focus on the calibration of Wi-Fi-based indoor tracking systems to be used by smartphones. The primary goal is to build an accurate and robust Wi-Fi signal propagation representation in indoor scenarios.We analyze the suitability of our approach in a smartphone-based indoor tracking system by introducing a novel in-motion calibration methodology using three different signal propagation characterizations supplemented with a particle filter. We compare the results obtained with each one of the three characterization in-motion calibration methodologies and those obtained using a static calibration approach, in a real-world scenario. Based on our experimental results, we show that the use of an in-motion calibration mechanism considerably improves the tracking accuracy.
"Conscious Procreation": Neo-malthusianism in Southern Europe and Latin America in aroun 1900 (ISEE, Montreal, July 2004) (2004)

ne main concern of Ecological Economics is balance between human population and natural resources. This is rightly named the Malthusian question because Malthus predicted that human populations, if unchecked, would grow exponentially while agricultural production (and other land-based productions) would be subject to decreasing returns to labour input. This article shows that over one hundred years ago, there was in Europe and America a successful social movement that called itself Neo-Malthusianism. In contrast to Malthus' pessimism, it believed that population growth could be stopped among poor classes by voluntary decisions. Women were entitled to choose number of children they wanted to have. The movement did not appeal to State to impose restrictions on population growth. On contrary, in Southern Europe it was based on bottom up activism against governments and Catholic Church.
ntf1+ encodes a 6-cysteine zinc finger-containing transcription factor that regulates the nmt1 promoter in fission yeast. (1994)

The nmt1+ gene of the fission yeast Schizosaccharomyces pombe is subject to transcriptional repression mediated by thiamine. The promoter of nmt1+ has been used to construct a series of vectors that are now commonly used for the regulated expression of genes in S. pombe. In this report, we described ntf1+, a gene involved in regulating nmt1+ expression. The ntf1+ gene was cloned in a high copy suppressor screen that utilized a construct, nmt1:wee1+, in which expression of the mitotic inhibitor Wee1 tyrosine kinase was placed under the control of the nmt1 promoter. ntf1+ encodes a 706-amino acid protein that shares substantial homology with a family of Cys6 zinc finger-containing transcription factors typified by GAL4 from Saccharomyces cerevisiae. Increased gene dosage of ntf1+ greatly increases both the repressed and derepressed activity of the nmt1 promoter. Cells having a disrupted version of ntf1+ are viable thiamine prototrophs, but basal expression from the nmt1 promoter is greatly reduced. These data demonstrate that Ntf1 plays an important role in regulating nmt1 expression.
Line pattern retrieval using relational histograms (1999)

This paper presents a new compact shape representation for retrieving line-patterns from large databases. The basic idea is to exploit both geometric attributes and structural information to construct a shape histogram. We realize this goal by computing the N-nearest neighbor graph for the lines-segments for each pattern. The edges of the neighborhood graphs are used to gate contributions to a two-dimensional pairwise geometric histogram. Shapes are indexed by searching for the line-pattern that maximizes the cross correlation of the normalized histogram bin-contents. We evaluate the new method on a database containing over 2,500 line-patterns each composed of hundreds of lines.
Lignin Determination by FT-IR (1992)

The lignin content of pulp is determined from its diffuse reflectance infrared spectrum by an algorithm that calculates the degree of overlap between two spectra. The lignin:cellulose fraction correlates with kappa number, a titrimetric measure of lignin. Essentially no sample preparation is required, and the procedure is insensitive to variations in moisture content. The algorithm is able to detect changes induced by exposure of pulp to NO 2 .
Application of a New Model to Analyze Leakoff Tests (1999)

Abstract A leak-off test (LOT), commonly known as formation pressure integrity test (PIT), is a verification method to estimate the fracture pressure of exposed formations. After cementing each casing string, a LOT is run to verify that the casing seat can withstand the wellbore pressure required to safely drill to the next casing setting depth. Fracture pressure determined from the test is used as the maximum pressure that may be imposed on that formation. Critical drilling decisions for subsequent casing setting depths are based upon the result of a LOT. Accurate formation fracture gradient determination is critically important. Although a LOT is a simple and inexpensive test, its interpretation is not always easy, particularly in formations that give non-linear relationships between the pumped volume and the observed pump pressure. Ideally, a straight-line relationship of pump pressure to volume pumped is obtained that reflects primarily the total system compressibility, i.e., the compressibility of the drilling fluid, casing expansion, and wellbore expansion. Non-linear LOT behavior is thought to be caused by gas in the system, by borehole failure, or by leakage of drilling fluid into the cemented casing/borehole annulus. There is, however, no mathematical model explaining the non-linear LOT behavior. Disagreement on determining or interpreting actual leak-off pressure from the test data among the operators is common, especially for shallow formations. In this study, a mathematical model is derived to assist in the analysis of non-linear LOT behavior. The model has been used to predict the observed non-linear behavior of field examples. In the case of a non-linear LOT, the model has also been used to predict the maximum fracture pressure of the formation without running a test until formation fracture.
Peripheral Neuromodulation for Migraine Headache (2011)

Extremely high prevalence among general population along with the high percentage of treatment-refractory cases makes migraine headaches one of the potentially largest indications for neuromodulation. Cranial peripheral nerve stimulation targeting the occipital nerve(s) alone or in combination with others appears to be both safe and efficacious for the treatment of medically intractable migraine headaches. Although initial reports of occipital nerve stimulation for migraine headaches were very encouraging, this clinical benefit was not clearly confirmed in larger-scale prospective randomized trials. Moreover, the exact mechanism of neuromodulation effect in migraine treatment remains unclear. Significant further investigation needs to be performed to optimize our knowledge concerning patient selection, stimulation targets and parameters and device programming, and further improve clinical results. At present, neurostimulation for migraine headache pain is performed in the United States on an 'off-label' basis, but based upon our experience and the increasing evidence in the medical literature, we look forward to its approval by the FDA in the near future so that patients suffering from severe, medically intractable headache pain may gain access to these potentially important therapies.
A Working Model for Mobile Charging using Wireless Power Transmission (2018)

Portable electronic devices are very popular nowadays. Almost all portable devices are battery powered, meaning that eventually, they all must be recharged–using the wired chargers currently being used. As the usage of these portable electronic devices is increasing, the demands for longer battery life are also increasing. These batteries need to be recharged or replaced periodically. It is a hassle to charge or change the battery after a while, especially when there is no power outlet around. Now instead of plugging in a cell phone, Personal Digital Assistant (PDA), digital camera, voice recorder, mp3 player or laptop to recharge it, it could receive its power wirelessly. The technology for Wireless Power Transmission or Wireless Power Transfer or Transmission (WPT) is in the forefront of electronic development. WPT systems are designed to transmit power without using wires more efficient than transmitting it while using wires. There could be large number of applications for wireless power systems. Hence, in this work, a wireless battery charger has been proposed for mobile phone charging which is expected to eliminate all the hassles with today’s battery technology. The advantage of this device is that it can wirelessly charge up the batteries which can save time and money in a long run for the general public.
Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism (1996)

Reactive oxygen species (ROS) have been implicated in the pathogenesis of a wide variety of respiratory diseases. We investigated mechanisms of ROS-induced mucin secretion by guinea pig tracheal epithelial (GPTE) cells in primary culture, and ROS-induced activation of the second messenger-producing enzyme phospholipase C (PLC), in GPTE cells and in a virally transformed cell line (BEAS-2B) derived from human bronchial epithelium. Mucin secretion was measured by a monoclonal antibody-based enzyme-linked immunosorbent assay, and PLC activation was assessed by anion exchange chromatography. ROS generated enzymatically by xanthine oxidase (XO, 500 microM) in the presence of purine (500 microM) enhanced release of mucin by GPTE cells and activated PLC in GPTE and BEAS cells. Hypersecretion of mucin and activation of PLC in response to purine + XO appeared to occur via an intracellular pathway(s) dependent on endogenously produced nitric oxide and possibly intracellularly generated oxidants. Both responses could be blocked or attenuated by preincubation of the cells with NG-monomethyl-L-arginine, an inhibitor of the enzyme nitric oxide synthase, or with dimethylthiourea, a compound that can react with a variety of intracellular oxidant species. Reactive nitrogen species generated chemically also stimulated secretion of mucin and activated PLC via a mechanism dependent (at least in part) on intracellular oxidant-mediated process(es). The results suggest that intracellularly generated radical species of nitrogen and oxygen may be important modulators of the response of airway epithelial cells to external oxidant stress.
Arginine vasopressin V1-antagonist and atrial natriuretic peptide reduce hemorrhagic brain edema in rats. (1992)

Antagonists to arginine vasopressin V1 receptors and atrial natriuretic peptide both significantly reduce hemorrhagic brain edema, and atrial natriuretic peptide appears to protect the blood-brain barrier.
Age-Related Changes of the Population of Human Ovarian Follicles: Increase in the Disappearance Rate of Non-Growing and Early-Growing Follicles in Aging Women (1994)

The effect of aging on the number of non-growing follicles (NGF) and early-growing follicles (EGF) was studied in humans through use of a database obtained by pooling two subsets of ovarian pairs (2 x 43 pairs) collected in two distinct populations. A previously suggested model of exponential regression of NGF counts in relation to the subject's age was tested but did not adequately fit the observed data points. This lack of fit is attributable mainly to the existence of a significant relation between a woman's age and the corresponding NGF count decay rate. Consequently, various regression models were tested. Two different periods of decay rate were observed for each population of small follicles. The first corresponds to younger ages with a decay rate that is slow for both types of follicles, although faster for NGF than for EGF. The second period corresponds to older ages with an accelerated decay rate that appears similar for NGF and EGF. The changing points were found at 38.0 +/- 2.4 and 39.0 +/- 1.9 yr (mean +/- SD) for NGF and EGF, respectively. Extrapolation of the fitted model suggested the presence of approximately 402,000 healthy NGF per ovary at birth and a total exhaustion of the follicular stock at around 74 yr of age. These results support the view that depletion of the NGF pool is caused mainly by atresia in younger women but mainly by entrance of NGF into the growing pool in older women. The mechanisms triggering accelerated entrance into the growth phase of NGF are discussed in relation to the previously reported increase in FSH plasma levels that starts in the late thirties, approximately, and precedes the menopausal period by several years.
Differential Activation of the c-Jun N-Terminal Kinase Pathway in Arsenite-Induced Apoptosis and Sensitization of Chemically Resistant Compared to Susceptible B-Lymphoma Cell Lines (2002)

Various forms of inorganic arsenic are significant environmental contaminants that have multiple effects on cells, including the induction of apoptotic cell death. Induction of apoptosis in lymphoid cells can mediate immunotoxicity following exposure to chemicals. However, the mechanisms regulating the sensitivity of B-lymphocytes to arsenic-induced apoptosis are not understood. Therefore, we investigated the involvement of key mitogen-activated protein kinase pathways and apoptosis induction by sodium arsenite in a model system of chemically resistant and susceptible B-lymphoma cell lines. These studies revealed a differential requirement for the c-Jun N-terminal kinase (JNK) pathway for apoptosis induction by sodium arsenite in the resistant EW36 versus sensitive ST486 cell lines. Specifically, activation of the JNK pathway was not required for arsenite-induced apoptosis in ST486 cells, whereas JNK pathway activation was always associated with apoptosis induction in EW36 cells. Importantly, we found that EW36 cells, which overexpress the Bcl-2 protein, can be substantially sensitized to arsenite-induced apoptosis by prior exposure to nonlethal hyperthermia. Moreover, pretreatment with an inhibitor of p38 kinase acted synergistically with hyperthermia to further sensitize EW36 cells. The inhibition of p38 prolonged a transient period of JNK phosphorylation that occurred immediately after heat shock treatment and involved the persistent activation of SEK1, one of the kinases upstream of JNK. Significantly, the sensitization of resistant cells is characterized by a lowering of the threshold concentration of arsenite required to activate the JNK pathway and induce apoptosis.
From Cirrhosis to Hepatocellular Carcinoma: New Molecular Insights on Inflammation and Cellular Senescence (2013)

Sequential progression from chronic liver disease to fibrosis and to cirrhosis culminates in neoplasia in hepatocellular carcinoma (HCC). The preneoplastic setting of the cirrhotic background provides a conducive environment for cellular transformation. The role of classical inflammation in cirrhosis is widely known, but the exact mechanism linking inflammation and cancer remains elusive. Recent studies have elucidated roles for NF-κB, STAT3 and JNK as possible missing links. In addition, the "inflammasome" (a multiprotein complex and sensor of cellular damage) is a recently identified player in this field. The hallmarks of cirrhosis include necroinflammation, deposition of extracellular matrix and shortening of telomeres, leading to senescence and regeneration. Additionally, the accumulation of genetic/epigenetic changes propels atypical cells toward a malignant phenotype. This review provides recent information on the classical inflammatory pathway, together with a spotlight on inflammasomes and the immunomodulatory role of cellular senescence during the progression from cirrhosis to HCC. Moreover, lacunae in the current knowledge were identified and key questions raised on whether the observed adaptive responses are beneficial or detrimental to tissue homeostasis in a complex organ like liver.
Role of gene fadR in Escherichia coli acetate metabolism (1981)

Mutants of Escherichia coli K-12 constitutive for fatty acid degradation (fadR) showed an increased rate of utilization of exogenous acetate. Acetate transport, oxidation, and incorporation into macromolecules was approximately fivefold greater in fadR mutants than fadR+ strains during growth on succinate as a carbon source. This effect was due to the elevated levels of glyoxylate shunt enzymes in fadR mutants, since (i) similar results were seen with mutants constitutive for the glyoxylate shunt enzymes (iclR), (ii) induction of the glyoxylate shunt in fadR+ strains by growth on acetate or oleate increased the rate of acetate utilization to levels comparable to those in fadR mutants, and (iii) fadR and fadR+ derivatives of mutants defective for the glyoxylate shunt enzymes showed equivalent rates of acetate utilization under these conditions. These results suggest that the operation of the glyoxylate shunt may play a significant role in the utilization of exogenous acetate by fadR mutants.
Mature form of interleukin 18 is expressed in rheumatoid arthritis synovial tissue and contributes to interferon-gamma production by synovial T cells. (2001)

These findings suggest that mature IL-18 is expressed in RA synovia and contributes to the production of IFN-gamma by infiltrating T cells.
Photostable Luminescent Nanoparticles as Biological Label for Cell Recognition of System Lupus Erythematosus Patients (2002)

In this article, we report a method for cell recognition of system lupus erythematosus (SLE) patients that uses photostable luminescent nanoparticles as biological labels. The luminescent silica nanoparticles are prepared with a water-in-oil microemulsion (W/O) technique. The silica network is produced by the controlled hydrolysis of tetraethylorthosilicate (TEOS) in water nanodroplets with the initiation of ammonia (NH3.H2O). A luminescent compound, tris(2,2'-bipyridyl)dichlororuthenium(II)hexahydrate [Ru(II)(bpy)3]2+, is doped inside as a luminescent signaling element, and the most appropriate dye concentration for the preparation of the nanoparticles with a size of 28 +/- 4 nm has been determined. The luminescent silica nanoparticles are covalently immobilized with goat anti-human immunoglobulin G (IgG), which can recognize SmIgG+ B lymphocytes. We have used antibody-labeled nanoparticles to recognize target SmIgG+ B lymphocytes isolated from the circulating blood of SLE patients. It has been observed that a bioassay based on fluorescent nanoparticles can identify target cells selectively and efficiently. And fluorescent nanoparticle labels also exhibit high photostability. The experiment results have shown that this cell recognition method was an effective one as further proof of the diagnosis of SLE.
Molecular Pathogenesis of Neuroendocrine Tumors: Implications for Current and Future Therapeutic Approaches (2013)

The treatment landscape and biologic understanding of neuroendocrine tumors (NET) has shifted dramatically in recent years. Recent studies have shown that somatostatin analogues have the potential not only to control symptoms of hormone hypersecretion but also have the ability to slow tumor growth in patients with advanced carcinoid. The results of clinical trials have further shown that the VEGF pathway inhibitor sunitinib and the mTOR inhibitor everolimus have efficacy in patients with advanced pancreatic NETs. The efficacy of these targeted therapies in NET suggests that the molecular characterization of NETs may provide an avenue to predict both which patients may benefit most from the treatment and to overcome potential drug resistance. Recent genomic studies of NETs have further suggested that pathways regulating chromatin remodeling and epigenetic modification may play a key role in regulating NET growth. These observations offer the potential for new therapeutic and diagnostic advances for patients with NET.
Unparalleled Ease of Access to a Library of Biheteroaryl Fluorophores via Oxidative Cross-Coupling Reactions: Discovery of Photostable NIR Probe for Mitochondria (2016)

The development of straightforward accesses to organic functional materials through C-H activation is a revolutionary trend in organic synthesis. In this article, we propose a concise strategy to construct a large library of donor-acceptor-type biheteroaryl fluorophores via the palladium-catalyzed oxidative C-H/C-H cross-coupling of electron-deficient 2H-indazoles with electron-rich heteroarenes. The directly coupled biheteroaryl fluorophores, named Indazo-Fluors, exhibit continuously tunable full-color emissions with quantum yields up to 93% and large Stokes shifts up to 8705 cm(-1) in CH2Cl2. By further fine-tuning of the substituent on the core skeleton, Indazo-Fluor 3l (FW = 274; λem = 725 nm) is obtained as the lowest molecular weight near-infrared (NIR) fluorophore with emission wavelength over 720 nm in the solid state. The NIR dye 5h specifically lights up mitochondria in living cells with bright red luminescence. Typically, commercially available mitochondria trackers suffer from poor photostability. Indazo-Fluor 5h exhibits superior photostability and very low cytotoxicity, which would be a prominent reagent for in vivo mitochondria imaging.
Control of nitrogen oxide emissions from coal combustion (1990)

The paper gives a discussion of the regulatory framework currently being used to limit nitrogen oxide (NOx) emissions, with emphasis being placed on EC and UN measures. It then follows with a discussion of the procedures being adopted at present to control or limit these emissions. The topics discussed include combustion modification measures, new combustion technologies, flue gas treatment, selective catalytic reduction, selective noncatalytic reduction and combined SOx/NOx processes.
Simple toys do not alter the behavior of aged rhesus monkeys (1991)

Abstract Simple toys and sticks have frequently been suggested as inexpensive forms of environmental enrichment for nonhuman primates. Most descriptions of these items do not provide quantitative data on their use, or the effects that their presence have on general behavior. We tested wooden sticks and four different dog toys with aged and young adult rhesus monkeys to determine whether or not they led to decreases in abnormal behaviors, or increases in activity. We monitored object‐use, abnormal behaviors, and general activity in a series of three experiments. Use of all objects tested declined sharply by the second day after they were placed in the cage. High levels of use were seen each time new objects were introduced, suggesting that a regular schedule of object rotation would lead to increased interest from the monkeys. No changes in abnormal behaviors or general activity were attributed to the presence of the objects. We conclude that sticks and simple toys have limited effectiveness as environmental enrichment options for aged rhesus monkeys. Where possible, socialization and/or actively responsive enrichment devices may be more effective in enhancing the lives of captive primates. In the case of animals in zoos, responsive environments and increased social opportunities also contribute to the educational, aesthetic, and health diagnostic missions of the institutions.
Sorafenib in Combination With Intensive Chemotherapy in Elderly Patients With Acute Myeloid Leukemia: Results From a Randomized, Placebo-Controlled Trial (2013)

In conclusion, combination of standard induction and consolidation therapy with sorafenib in the schedule investigated in our trial is not beneficial for elderly patients with AML.