gebhart/patrepeval huggingface dataset:
Reducing the Paging Overhead in Highly Directional Systems (2021)

New Radio (NR) supports operations at high-frequency bands (e.g., millimeter-wave frequencies) by using narrow beam based directional transmissions to compensate high propagation losses at such frequencies. Due to the limited spatial coverage with each beam, the broadcast transmission of paging in NR is performed using beam sweeping, which takes multiple time slots. Thus, the paging procedure used in NR would substantially increase the downlink resource overhead of the network with directional transmissions. Such overhead would further increase as we move higher in the frequency bands, such as terahertz bands, which is being viewed as one of the potential candidates for future generation networks. Therefore, the NR based paging solution is infeasible for supporting highly directional systems. In this paper, we propose a novel minimal feedback enabled paging mechanism, which instead of using all the beams for paging transmissions, only activates sub-set of beams having one or more UEs under the coverage. UE presence indications are implemented to identify the correct set of beams to be activated. Our analytical analysis and simulations show that the proposed solution significantly reduces the downlink paging overhead compared to the NR based solution (e.g., more than 80% gain for a system supporting 64 number of beams at a UE density of 200 UEs per paging occasion) while incurring minimal energy cost at the UE side.
Huntingtin contains a highly conserved nuclear export signal (2003)

Huntington's disease (HD), is a genetic neurodegenerative disease characterized by a DNA CAG triplet repeat expansion in the first exon of the disease gene, HD. CAG DNA expansion results in a polyglutamine tract expansion in mutant huntingtin protein. Wild-type and mutant full-length huntingtin have been detected in the nucleus, but elevated levels of mutant huntingtin and huntingtin amino-terminal proteolytic fragments are seen to accumulate in the nuclei of HD-affected neurons. The presence of huntingtin in both the nucleus and the cytoplasm suggested that huntingtin may be dynamic between these compartments. By live cell time-lapse video microscopy, we have been able to visualize polyglutamine-mediated aggregation and the transient nuclear localization of huntingtin over time in a striatal cell line. A classical nuclear localization signal could not be detected in huntingtin, but we have discovered a nuclear export signal (NES) in the carboxy-terminus of huntingtin. Leptomycin B treatment of clonal striatal cells enhanced the nuclear localization of huntingtin, and a mutant NES huntingtin displayed increased nuclear localization, indicating that huntingtin can shuttle to and from the nucleus. The huntingtin NES is strictly conserved among all huntingtin proteins from diverse species. This export signal may be important in Huntington's disease because this fragment of huntingtin is proteolytically cleaved away during HD. The huntingtin NES therefore defines a potential role for huntingtin as a member of a nucleocytoplasmic dynamic protein complex.
Doppler-free three-photon coherence in Doppler-broadened diamond-type atomic system (2017)

We investigated the relationship between three-photon electromagnetically induced absorption (TPEIA) and four-wave mixing (FWM) in the 5S<sub>1/2</sub>-5P<sub>3/2</sub>-5D<sub>5/2</sub> transition of <sup>87</sup>Rb atoms. When the driving field was additionally coupled to the ground and intermediate states of a lower V-type configuration in a typical ladder-type electromagnetically induced transparency (EIT) system, Doppler-free TPEIA and FWM spectra were simultaneously observed and then analyzed from the perspective of multi-photon atomic coherence. Comparing the TPEIA and FWM spectra according to the laser frequency detuning and laser intensity, we found that the enhanced TPEIA signal is strongly correlated with the generated FWM light. Analytical and numerical calculations for the analysis of the relationship are presented.
The role of the seminal vesicles, coagulating glands and prostate glands on the fertility and fecundity of mice (1979)

Female mice were allowed to mate with males which had been sham-operated (Group 1); had seminal vesicles, coagulating glands and ventral and dorsal prostate glands removed (Group 2); had the seminal vesicles removed (Group 3); had the coagulating glands removed (Group 4) or had the ventral and dorsal prostate gland removed (Group 5). The pregnancy rate was normal in Groups 1 and 4, severely reduced in Groups 2 and 3 and less so in Group 5. Litter size was reduced in Groups 2 and 3 but not in Group 5. It is suggested that the seminal vesicles and possibly the prostate glands are important in the production of young in mice.
Update on the management of cutaneous lupus erythematosus (2004)

This paper reviews the latest treatments for cutaneous lupus erythematosus. It focuses on evidence-based guidance for the management of cutaneous lupus erythematosus, with identification of the strength of evidence available at this time. In addition, I have briefly reviewed the epidemiological aspects, diagnosis and evaluation of patients with cutaneous lupus erythematosus. This review reflects data available from the Cochrane Library, Medline, literature searches, and the experience of the author managing patients with cutaneous lupus erythematosus for over 25 years.
The developmental origins of adipose tissue (2013)

Adipose tissue is formed at stereotypic times and locations in a diverse array of organisms. Once formed, the tissue is dynamic, responding to homeostatic and external cues and capable of a 15-fold expansion. The formation and maintenance of adipose tissue is essential to many biological processes and when perturbed leads to significant diseases. Despite this basic and clinical significance, understanding of the developmental biology of adipose tissue has languished. In this Review, we highlight recent efforts to unveil adipose developmental cues, adipose stem cell biology and the regulators of adipose tissue homeostasis and dynamism.
ISOWN: accurate somatic mutation identification in the absence of normal tissue controls (2017)

In this work, we describe the development, implementation, and validation of ISOWN, an accurate algorithm for predicting somatic mutations in cancer tissues in the absence of matching normal tissues. ISOWN is available as Open Source under Apache License 2.0 from https://github.com/ikalatskaya/ISOWN .
New Industrial Products from Starch (1988)

Abstract The industrial (non‐food) use of starch and starch‐based products as renewable raw materials is discussed together with examples, in the following application areas: –Starch as auxiliary raw material: binder, adhesive, thickener, protective colloid. –Starch as raw material for new products in chemical or biotechnical processes: polyols, acids, polysaccharides, enzymes. –Starch as filler with specific functionality for synthetic polymers to improve application properties in e. g. polyethylene, polypropylene, polystyrene, polyurethane‐foams, styrene/butadiene copolymers, polyvinylchloride. –Starch as reactive component to be incorporated during production of synthetic polymers leading to synergistic effects: urea/formaldehyde resins, phenolic resins, alkyd‐ and melamine resins. –Starch‐based active materials which either exhibit direct functionality themselves, (e. g. as surfactants, sequestrants and bleaching boosters) or which represent building blocks for the synthesis of chiral compounds for the pharmaceutical or the agro‐industries.
Reconstructing non-stationary articulated objects in monocular video using silhouette information (2008)

This paper presents an approach to reconstruct non-stationary, articulated objects from silhouettes obtained with a monocular video sequence. We introduce the concept of motion blurred scene occupancies, a direct analogy of motion blurred images but in a 3D object scene occupancy space resulting from the motion/deformation of the object. Our approach starts with an image based fusion step that combines color and silhouette information from multiple views. To this end we propose to use a novel construct: the temporal occupancy point (TOP), which is the estimated 3D scene location of a silhouette pixel and contains information about duration of time it is occupied. Instead of explicitly computing the TOP in 3D space we directly obtain itpsilas imaged(projected) locations in each view. This enables us to handle monocular video and arbitrary camera motion in scenarios where complete camera calibration information may not be available. The result is a set of blurred scene occupancy images in the corresponding views, where the values at each pixel correspond to the fraction of total time duration that the pixel observed an occupied scene location. We then use a motion de-blurring approach to de-blur the occupancy images. The de-blurred occupancy images correspond to a silhouettes of the mean/motion compensated object shape and are used to obtain a visual hull reconstruction of the object. We show promising results on challenging monocular datasets of deforming objects where traditional visual hull intersection approaches fail to reconstruct the object correctly.
Theory of cascaded quarter wave shifted distributed feedback resonators (1992)

The theory of lambda /4 shifted DFB resonators, both series coupled and side coupled, is developed. The theory is limited to loss-free high-Q resonators. If the actual losses are too high, the internal losses of the structures, all of which are compatible with laser diode structures, can be compensated by gain via carrier injection. The theory of a simple transmission resonator is reviewed and extended to a side-coupled resonator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Calcium intake, calcium bioavailability and bone health (2002)

Calcium accounts for 1-2 % of adult human body weight. Over 99 % of total body Ca is found in the teeth and bones. Therefore, in addition to the obvious structural role of the skeleton, it also serves as a reservoir for Ca. Dietary Ca intake has an important impact on bone metabolism and bone health. Chronic Ca deficiency resulting from inadequate intake or poor intestinal absorption is one of several important causes of reduced bone mass and osteoporosis. It is vital, therefore, that adequate dietary Ca is consumed at all stages of life - in early life so that the genetically programmed peak bone mass can be reached and in later adulthood so that the skeletal mass can be maintained and age-related bone loss minimised. Unfortunately, there is wide variation in the estimates of daily Ca requirements made by different expert authorities. Furthermore, there is evidence that many individuals are not consuming these recommended levels. The consequence of this for bone health will be discussed in the present review. Besides the amount of Ca in the diet, the absorption of dietary Ca in foods is also a critical factor in determining the availability of Ca for bone development and maintenance. Thus, there is a need to identify food components and/or functional food ingredients that may positively influence Ca absorption in order to ensure that Ca bioavailability from foods can be optimised. This approach may be of particular value in individuals who fail to achieve the dietary recommended level of Ca.
IMMUNITY TO STREPTOCOCCUS EQUI (1975)

Using the long chain test, and in some cases the bactericidal test, to measure antibody, the development of the immune response in horses to Str. equi has been followed. Long chain indices in excess of 5.0, accompanied by strong bactericidal capacity, were recorded in serums after the full 3-dose immunisation course with a commercial vaccine. The full course elicited the most satisfactory antibody titres declined within the 12 month post-vaccination period, thus providing support for the recommendation that yearly booster doses should be administered. The immune response in horses during 2 strangles outbreaks was compared with the response following vaccination. Recovered animals showed declining antibody levels 9 weeks after infection, and the evidence does not support longevity of the immune response after natural infection. Reaction to vaccination was observed in those animals with high initial antibody titre.
Self deployable deep sea moorings (1992)

development effort in the fi e 1 d of moored arrays
Radiation Dosimetry for<sup>177</sup>Lu-PSMA I&T in Metastatic Castration-Resistant Prostate Cancer: Absorbed Dose in Normal Organs and Tumor Lesions (2016)

Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy is increasingly used in metastatic castration-resistant prostate cancer. We aimed to estimate the absorbed doses for normal organs and tumor lesions using <sup>177</sup>Lu-PSMA I&T (I&T is imaging and therapy) in patients undergoing up to 4 cycles of radioligand therapy. Results were compared with pretherapeutic Glu-NH-CO-NH-Lys-(Ahx)-[<sup>68</sup>Ga(HBEDCC)] (<sup>68</sup>Ga-PSMA-HBED-CC) PET. <b>Methods:</b> A total of 34 cycles in 18 patients were analyzed retrospectively. In 15 patients the first, in 9 the second, in 5 the third, and in 5 the fourth cycle was analyzed, respectively. Whole-body scintigraphy was performed at least between 30-120 min, 24 h, and 6-8 d after administration. Regions of interest covering the whole body, organs, and up to 4 tumor lesions were drawn. Organ and tumor masses were derived from pretherapeutic <sup>68</sup>Ga-PSMA-HBED-CC PET/CT. Absorbed doses for individual cycles were calculated using OLINDA/EXM. SUVs from pretherapeutic PET were compared with absorbed doses and with change of SUV. <b>Results:</b> The mean whole-body effective dose for all cycles was 0.06 ± 0.03 Sv/GBq. The mean absorbed organ doses were 0.72 ± 0.21 Gy/GBq for the kidneys; 0.12 ± 0.06 Gy/GBq for the liver; and 0.55 ± 0.14 Gy/GBq for the parotid, 0.64 ± 0.40 Gy/GBq for the submandibular, and 3.8 ± 1.4 Gy/GBq for the lacrimal glands. Absorbed organ doses were relatively constant among the 4 different cycles. Tumor lesions received a mean absorbed dose per cycle of 3.2 ± 2.6 Gy/GBq (range, 0.22-12 Gy/GBq). Doses to tumor lesions gradually decreased, with 3.5 ± 2.9 Gy/GBq for the first, 3.3 ± 2.5 Gy/GBq for the second, 2.7 ± 2.3 Gy/GBq for the third, and 2.4 ± 2.2 Gy/GBq for the fourth cycle. SUVs of pretherapeutic PET moderately correlated with absorbed dose (<i>r</i> = 0.44, <i>P</i> < 0.001 for SUV<sub>max</sub>; <i>r</i> = 0.43, <i>P</i> < 0.001 for SUV<sub>mean</sub>) and moderately correlated with the change of SUV (<i>r</i> = 0.478, <i>P</i> < 0.001 for SUV<sub>max</sub>, and <i>r</i> = 0.50, <i>P</i> < 0.001 for SUV<sub>mean</sub>). <b>Conclusion:</b> Organ- and tumor-absorbed doses for <sup>177</sup>Lu-PSMA I&T are comparable to recent reports and complement these with information on an excellent correlation between the 4 therapy cycles. With the kidneys representing the critical organ, a cumulative activity of 40 GBq of <sup>177</sup>Lu-PSMA I&T appears to be safe and justifiable. The correlation between pretherapeutic SUV and absorbed tumor dose emphasizes the need for PSMA-ligand PET imaging for patient selection.
Device-level early floorplanning algorithms for RF circuits (1998)

High-frequency circuits are notoriously difficult to lay out because of the tight coupling between device-level placement and wiring. Given that successful electrical performance requires careful control of the lowest-level geometric features—wire bends, precise length, proximity, planarity, etc.—we suggest a new layout strategy for these circuits: early floorplanning at the device level. This paper develops a floorplanner for RF circuits based on a genetic algorithm (GA) that supports fully simultaneous placement and routing. The GA evolves slicing-style floorplans comprising devices and planned areas for wire meanders. Each floorplan candidate is fully routed with a gridless, detailed maze-router which can dynamically resize the floorplan as necessary. Experimental results demonstrate the ability of this approach to successfully optimize for wire planarity, realize multiple constraints on net lengths or phases, and achieve reasonable area in modest CPU times.
Efficient Video Similarity Measurement and Search (2002)

The amount of information on the world wide web has grown enormously since its creation in 1990. Duplication of content is inevitable because there is no central management on the web. Studies have shown that many similar versions of the same text documents can be found throughout the web. This redundancy problem is more severe for multimedia content such as web video sequences, as they are often stored in multiple locations and different formats to facilitate downloading and streaming. Similar versions of the same video can also be found, unknown to content creators, when web users modify and republish original content using video editing tools. Identifying similar content can benefit many web applications and content owners. For example, it will reduce the number of similar answers to a web search and identify inappropriate use of copyright content. In this dissertation, they present a system architecture and corresponding algorithms to efficiently measure, search, and organize similar video sequences found on any large database such as the web.
Interaction among autoregulation, CO<sub>2</sub> reactivity, and intracranial pressure: a mathematical model (1998)

The relationships among cerebral blood flow, cerebral blood volume, intracranial pressure (ICP), and the action of cerebrovascular regulatory mechanisms (autoregulation and CO2 reactivity) were investigated by means of a mathematical model. The model incorporates the cerebrospinal fluid (CSF) circulation, the intracranial pressure-volume relationship, and cerebral hemodynamics. The latter is based on the following main assumptions: the middle cerebral arteries behave passively following transmural pressure changes; the pial arterial circulation includes two segments (large and small pial arteries) subject to different autoregulation mechanisms; and the venous cerebrovascular bed behaves as a Starling resistor. A new aspect of the model exists in the description of CO2 reactivity in the pial arterial circulation and in the analysis of its nonlinear interaction with autoregulation. Simulation results, obtained at constant ICP using various combinations of mean arterial pressure and CO2 pressure, substantially support data on cerebral blood flow and velocity reported in the physiological literature concerning both the separate effects of CO2 and autoregulation and their nonlinear interaction. Simulations performed in dynamic conditions with varying ICP underline the existence of a significant correlation between ICP dynamics and cerebral hemodynamics in response to CO2 changes. This correlation may significantly increase in pathological subjects with poor intracranial compliance and reduced CSF outflow. In perspective, the model can be used to study ICP and blood velocity time patterns in neurosurgical patients in order to gain a deeper insight into the pathophysiological mechanisms leading to intracranial hypertension and secondary brain damage.
Estimating the equity premium (1999)

Accurate estimation of the equity premium (the expected difference between the returns to a well-diversified stock market portfolio and a riskfree asset) is of central importance in many applications of finance theory including project appraisal and portfolio selection. The standard approach is to take the average observed excess returns to the market over some recent time period (sometimes referred to as the ex post equity premium) and apply this as an unbiased estimate of the ex ante equity premium. The paper reviews the problems associated with such an approach and contrasts it with alternative theoretical techniques.
Stability and Reversibility of Thermal Denaturation Are Greatly Improved by Limiting Terminal Flexibility of Escherichia coli Dihydrofolate Reductase (1996)

Short peptides which contained a single Cys residue were introduced into both N- and C-termini of the Cys-free mutant of DHFR (Cys85 --> Ala, Cys152 --> Ser double mutant) by a recombinant DNA method, then the terminal regions were connected through a disulfide bond by oxidation. The oxidized form and reduced form proteins have as high enzymatic activity as wild-type DHFR. There is no detectable difference between the CD spectra of the reduced and oxidized forms at low (15 degrees C, native condition) and high temperature (80 degrees C, unfolded condition). The thermal transition of the oxidized proteins at the concentration of 0.15 mg/ml (8.5 microM) is completely reversible as demonstrated by the CD spectra. No aggregated materials were detected in the oxidized protein on gel-filtration HPLC after heat treatment up to the protein concentration of 0.5 mg/ml. The reduced protein, however, even in the presence of reducing agent, showed only partial reversibility, with as much as 55 and 95% of the heat-treated protein at the concentrations of 0.15 and 0.5 mg/ml being eluted as the high molecular aggregated form, respectively. The apparent transition temperatures (Tm) of the oxidized forms were 5-7 degrees C higher than those of the reduced counterparts. The oxidized protein that had been denatured with guanidine-HCl was eluted later than the denatured reduced protein on gel-filtration HPLC in the presence of 5 M guanidine-HCl. The limitation of spatial movement of the termini may prevent intermolecular interaction of exposed domains during denaturation-renaturation process, giving rise to the irreversible denaturation. The flexibility of the terminal is also suggested to be an important factor for improving thermal stability of proteins.
Monte Carlo sampling of solutions to inverse problems (1995)

Probabilistic formulation of inverse problems leads to the definition of a probability distribution in the model space. This probability distribution combines a priori information with new information obtained by measuring some observable parameters (data). As, in the general case, the theory linking data with model parameters is nonlinear, the a posteriori probability in the model space may not be easy to describe (it may be multimodal, some moments may not be defined, etc.). When analysing an inverse problem, obtaining a maximum likelihood model is usually not sufficient, as we normally also wish to have information on the resolution power of the data. In the general case we may have a large number of model parameters, and an inspection of the marginal probability densities of interest may be impractical, or even useless. But it is possible to pseudorandomly generate a large collection of models according to the posterior probability distribution and to analyse and display the models in such a way that information on the relative likelihoods of model properties is conveyed to the spectator. This can be accomplished by means of an efficient Monte Carlo method, even in cases where no explicit formula for the a priori distribution is available. The most well known importance sampling method, the Metropolis algorithm, can be generalized, and this gives a method that allows analysis of (possibly highly nonlinear) inverse problems with complex a priori information and data with an arbitrary noise distribution.