gebhart/patrepeval huggingface dataset:
The Drug-Free Workplace Act of 1988 (1992)

With the influx of the 80's anti-drug movement into the workplace, in the fonm of the Drug-Free Workplace Act of 1988, private contractors concerned about compliance with the Act may turn in increasing numbers to Employee Assistance Programs. To determine if such a trend already exists, a survey of 44 small businesses was completed, to discover if an awareness of the Act and its requirements, along with the perceived need or intent to comply, would be associated with the increased presence of EMS, drug testing, drug policies or drug awareness programs. The participants were also asked how they would respond to an identified drug user in the workplace. As predicted, the results showed that companies who were aware of the Act and its requirements, or who believed they are accountable, were more likely to implement various drug program elements, such as EAPs. Also as predicted, the combined use of both treatment and discipline in response to workplace drug abuse was more likely to be found in companies that were aware of and accountable to the recent legislation. Further questions are raised about the long-term results of federal legislation on the private sector, EAPs and chemically dependent employees.
Temperature-sensitive Mutant of the Caenorhabditis elegans Neurotoxic MEC-4(d) DEG/ENaC Channel Identifies a Site Required for Trafficking or Surface Maintenance (2005)

DEG/ENaC channel subunits are two transmembrane domain proteins that assemble into heteromeric complexes to perform diverse biological functions that include sensory perception, electrolyte balance, and synaptic plasticity. Hyperactivation of neuronally expressed DEG/ENaCs that conduct both Na+ and Ca2+, however, can potently induce necrotic neuronal death in vivo. For example, Caenorhabditis elegans DEG/ENaC MEC-4 comprises the core subunit of a touch-transducing ion channel critical for mechanosensation that when hyperactivated by a mec-4(d) mutation induces necrosis of the sensory neurons in which it is expressed. Thus, studies of the MEC-4 channel have provided insight into both normal channel biology and neurotoxicity mechanisms. Here we report on intragenic mec-4 mutations identified in a screen for suppressors of mec-4(d)-induced necrosis, with a focus on detailed characterization of allele bz2 that has the distinctive phenotype of inducing dramatic neuronal swelling without being fully penetrant for toxicity. The bz2 mutation encodes substitution A745T, which is situated in the intracellular C-terminal domain of MEC-4. We show that this substitution renders both MEC-4 and MEC-4(d) activity strongly temperature sensitive. In addition, we show that both in Xenopus oocytes and in vivo, substitution A745T disrupts channel trafficking or maintenance of the MEC-4 subunit at the cell surface. This is the first demonstration of a C-terminal domain that affects trafficking of a neuronally expressed DEG/ENaC. Moreover, this study reveals that neuronal swelling occurs prior to commitment to necrotic death and defines a powerful new tool for inducible necrosis initiation.
Determining Hydrogen Fluoride Mirror Reflectances With The Cavity Phase Shift Method (1984)

Current work with the cavity phase shift (CAPS) method concentrates on hydrogen fluoride laser wavelengths between 2.6 and 3.0 um. This method and continued advancements in experimental techniques are described. With use of a cavity dither the accuracy of reflectance measurements has been improved over previous work to ±0.0004 for reflectances around 0.995. Results of measurements on dielectric-coated elements are reported, as are studies on metallic monolayers placed on nontransmitting substrates. The required CAPS configuration in these cases is a three-mirror arrangement permitting angle-of-incidence variation. In this mode the CAPS method becomes a verification technique for optical coatings on particular resonator designs.
Messaging Forensic Framework for Cybercrime Investigation (2011)

Online predators, botmasters, and terrorists abuse the Internet and associated web technologies by conducting illegitimate activities such as bullying, phishing, and threatening. These activities often involve online messages between a criminal and a victim, or between criminals themselves. The forensic analysis of online messages to collect empirical evidence that can be used to prosecute cybercriminals in a court of law is one way to minimize most cybercrimes. The challenge is to develop innovative tools and techniques to precisely analyze large volumes of suspicious online messages. We develop a forensic analysis framework to help an investigator analyze the textual content of online messages with two main objectives. First, we apply our novel authorship analysis techniques for collecting patterns of authorial attributes to address the problem of anonymity in online communication. Second, we apply the proposed knowledge discovery and semantic anal ysis techniques for identifying criminal networks and their illegal activities. The focus of the framework is to collect creditable, intuitive, and interpretable evidence for both technical and non-technical professional experts including law enforcement personnel and jury members. To evaluate our proposed methods, we share our collaborative work with a local law enforcement agency. The experimental result on real-life data suggests that the presented forensic analysis framework is effective for cybercrime investigation.
Molecular Weight Distribution of (Semi-) Commercial Lignin Derivatives (1993)

Abstract Absolute molecular weights of several commercially and semi-commercially available lignins were determined by gel permeation chromatography (GPC with a differential viscosity detector (DV). Solubility in THF was assured by acetylation. Polystyrene molecular weight standards were used for establishing a universal calibration curve. The lignins included those from hardwood, softwood, and sugar cane bagasse; and these were isolated by the kraft or organosolv pulping process, or by steam explosion/autohydrolysis. All lignins exhibited more or less uniform distributions with weight average molecular weights (Mw) between 3, 000 and 20, 000; with polydispersities (Mw/Mn)between 2 and 12; with Mark-Houwink-Sakurada exponential factors (α) between 0.17 and 0.35; and with intrinsic viscosities between 0.037 and 0.08 dLg−1. A significant relationship between Mw/Mn and Mw was discovered that had a correlation factor of 0.92. This relationship has the form of Mw/Mn = 0.45 (Mw 10−3 + 0.85.
PocketThumb (2017)

We present PocketThumb, a wearable touch interface for smart-eyewear that is embedded into the fabrics of the front trouser pocket. The interface is reachable from outside and inside of the pocket to allow for a combined dual-sided touch input. The user can control an absolute cursor with their thumb sliding along the fabric from the inside, while at the same time tapping or swiping with fingers from the outside to perform joint gestures. This allows for resting the hand in a comfortable and quickly accessible position, while performing interaction with a high expressiveness that is feasible in mobile scenarios. In a cursor-based target selection study, we found that our introduced dual-sided touch interaction is significantly faster in comparison to common single-sided absolute as well as relative touch interaction (~19%, resp. ~23% faster). The effect is largest in the mobile conditions standing and walking (up to ~31% faster).
Alpha-synuclein truncation and disease (2012)

Alpha-synuclein is the major component of Lewy bodies, insoluble protein aggregates, found in patients with Parkinson’s disease, diffuse Lewy body disease, and the Lewy body variant of Alzheimer’s disease. Alpha-synuclein has been found within Lewy bodies to contain many different modifications, including nitration, phosphorylation, ubiquitination, and truncation. C-terminally truncated forms of alpha-synuclein aggregate faster than the full-length protein in vitro, and are thus believed to play a role in Lewy body formation and disease progression. Pathological studies of post mortem brain tissue and the generation of transgenic mouse models further support a role of C-terminally truncated forms of alpha-synuclein in disease. Several enzymes, some of which function extracellularly, have been implicated in the production of these C-terminally truncated forms of alpha-synuclein. However, the enzymes responsible for alphasynuclein truncation in vivo have not yet been firmly established.
How to manage Pseudomonas aeruginosa infections (2018)

Infections with <i>Pseudomonas aeruginosa</i> have become a real concern in hospital-acquired infections, especially in critically ill and immunocompromised patients. The major problem leading to high mortality lies in the appearance of drug-resistant strains. Therefore, a vast number of approaches to develop novel anti-infectives is currently pursued. Diverse strategies range from killing (new antibiotics) to disarming (antivirulence) the pathogen. In this review, selected aspects of <i>P. aeruginosa</i> antimicrobial resistance and infection management will be addressed. Many studies have been performed to evaluate the risk factors for resistance and the potential consequences on mortality and attributable mortality. The review also looks at the mechanisms associated with resistance - <i>P. aeruginosa</i> is a pathogen presenting a large genome, and it can develop a large number of factors associated with antibiotic resistance involving almost all classes of antibiotics. Clinical approaches to patients with bacteremia, ventilator-associated pneumonia, urinary tract infections and skin soft tissue infections are discussed. Antibiotic combinations are reviewed as well as an analysis of pharmacokinetic and pharmacodynamic parameters to optimize <i>P. aeruginosa</i> treatment. Limitations of current therapies, the potential for alternative drugs and new therapeutic options are also discussed.
Design, fabrication, installation, and testing of high energy sweeper (2006)

A room temperature high-energy sweeper had been designed, fabricated, and installed at the postacceleration section of the Tandem accelerator. The sweeper, a part of the new pulsing system, is being used to inject the bunched beam without dark current into the linear accelerator acting as a booster of the Tandem. The resonance frequency of the sweeper was set at 6.0625MHz and a quality factor of ∼1300 was achieved. During off-line testing of the sweeper, a deflector voltage of ∼30kV had been measured for an input power of 300W. A pair of indigenously fabricated capacitors is used for fine-tuning of the resonance frequency. The silver plated coil of the tank circuit was fabricated with two concentric copper tubes. During the successful beam test of the sweeper, a peak to dark current ratio of 97% has been achieved.
Activation of arginine and tyrosine esterase in serum from patients with hereditary angio‐oedema (1972)

1. The role of clotting factor XII in the activation of the complement subunit C1s to C1 esterase was examined.2. In sera from patients with hereditary angio-oedema who lack the alpha(2)-glycoglobulin C1 inhibitor, silicates and other potent activators of clotting factor XII induced far less C1 esterase activity than did the weaker factor XII activators, carrageenin and cellulose sulphate. In contrast, the intensity of the induced plasma kallikrein activity corresponded more closely to the clot-promoting effect of the factor XII activators.3. Spontaneous generation of C1 esterase activity was only slightly delayed in hereditary angio-oedema sera previously depleted of factor XII. In normal sera, C1 esterase did not develop spontaneously and could not be induced.4. Experiments with inhibitors suggested that the spontaneous activation of C1s may consist of two phases: factor XII and other plasma proteases first activate small amounts of C1s; the resulting C1 esterase then activates the bulk of C1s. The observed spontaneous activation suggests that when fully activated, the C1s present in 1 ml of human serum will hydrolyse 1-2 mumol of ATEe/minute.
Partial Purification and Characterization of Thyrotropin Binding Inhibitory Immunoglobulins from Normal Human Plasma* (1983)

Whole human plasma contains a factor that inhibits the binding of bovine TSH to human thyroid membranes. To determine whether this activity is attributable to the presence of small amounts of immunoglobulin G (IgG) molecules that bind specifically to the thyroid, we have extracted from normal human plasma by a process of selective membrane adsorption a subfraction of IgG that is much more potent in TSH binding inhibition that the starting IgG. The enriched fraction was shown to be IgG by multiple criteria: precipitation in ammonium sulfate, elution by the anion exchange resin DEAE-cellulose, and electrophoresis in sodium dodecyl sulfate-urea polyacrylamide gel. Pretreatment with staphylococcal protein A, with specifically binds IgG, completely removed its activity. Significant TSH binding inhibition was retained under salt conditions, which have been shown to optimize the sensitivity and specificity of the TSH receptor. The enriched fraction was not an antimicrosomal or antithyroglobulin antibody, and did not bind to the TSH label. A similar enriched subfraction of bovine TSH binding inhibitory IgG could be prepared using membranes obtained from kidney and liver, suggesting that the membrane antigen with which it bound was not thyroid specific. These data indicate that in the plasma of individuals presumed to be free of thyroid disease there circulates low concentrations of an IgG which reacts with a thyroid membrane antigen(s). It may be an autoantibody or a normal constituent of plasma with specific binding properties.
Open Source Software Hosting Platforms: A Collaborative Perspective’s Review (2017)

Open source software (OSS) has been gaining large attention lately. In fact, several studies have shown that the collaboration is a remarkably major factor influencing the OSS quality. In addition, there are several existing platforms providing mediums for collaborative development of the OSS projects and involve advanced features that assist in boosting the collaboration process. Such platforms which can be called as open source software hosting platforms are rich of collaborative workflows. Therefore, in this research a comprehensive investigation of the current OSS hosting platforms is held for the sake of studying their collaboration capabilities as well as pointing out any limitations related to collaboration that might hinder OSS from meeting high quality. The review has shown that the current OSS hosting platforms have some potential limitations. The identified limitations have been shared through a survey with developers working on OSS platforms and the results have generally revealed that there is a necessity to overcome these limitations.
Stable pushing: mechanics, controllability, and planning (1995)

We would like to give robots the ability to position and orient parts in the plane by pushing, particularly when the parts are too large or heavy to be grasped and lifted. Unfortunately, the motion of a pushed object is generally unpredictable due to unknown support friction forces. With multiple pushing contact points, however, it is possible to find pushing directions that cause the object to remain fixed to the manipulator. These are called stable pushing directions. In this article we consider the problem of planning pushing paths using stable pushes. Pushing imposes a set of nonholonomic velocity constraints on the motion of the object, and we study the issues of local and global controllability during pushing with point contact or stable line contact. We describe a planner for finding stable pushing paths among obstacles, and the planner is demon strated on several manipulation tasks.
Video signal processing LSI for MUSE/NTSC converter (1990)

Applying 1.2- mu m CMOS technology, the authors have developed video signal processing LSIs for the MUSE/NTSC converter. A MUSE/NTSC converter can be constructed easily by adding an A/D converter, a D/A converter, memory, audio signal processing, and an I/O analog processing circuit to the video signal LSI. Picture quality obtained with this converter is superior to that of the conventional NTSC system. The functions and characteristics of the LSIs are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Development of radio frequency induction plasma generators for neutral beams (1986)

The techniques, operational aspects, and experimental results of a radio frequency induction plasma generator, with an internal rf power coupler, intended for intense neutral beam applications are described. One of the development sources suitable for 10×10-cm2 extraction optics was operated to a deuterium ion current density of 250 mA/cm2, uniform to 5%, over a circular extraction area 15 cm in diameter with a coupled rf power of 20 kW. Temporal fluctuation levels in the extracted ion current were measured to be typically 1% of the dc level. A second developmental source suitable for 10×40-cm2 grid sets was operated to 200 mA/cm2, uniform to ±8% over a 10×40 cm2 area, with 40-kW coupled rf power.
Toward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation (AD). 1. Kinetics (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTToward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation (AD). 1. KineticsHartmuth C. Kolb, Pher G. Andersson, and K. Barry SharplessCite this: J. Am. Chem. Soc. 1994, 116, 4, 1278–1291Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://doi.org/10.1021/ja00083a014RIGHTS & PERMISSIONSArticle Views2689Altmetric-Citations183LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (5 MB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Concurrent off-phase built-in self-test of dormant logic (2003)

Concurrent off-phase built-in self-test is described, which permits the operation of built-in self-test hardware designed for offline testing concurrently with normal system operations. It takes advantage of the logic dormancy characteristic of designs which use two-phase clocking. This method provides online detection for permanent faults and can be used in conjunction with a time-redundant concurrent test method to detect transient and intermittent as well as permanent faults. Also, the method provides guaranteed self-test for self-checking circuits. Concurrent off-phase BIST requires duplication of storage elements but otherwise makes use of BIST hardware used for noncurrent, offline testing. Also, there may be an associated time penalty which, for the given example of CMOS technology with a symmetric phase clock period of 50 ns, is estimated to be an 11.6% increase in the clock period.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Embedded image-domain adaptive compression of simple images (2002)

Popular transform coding techniques provide excellent lossy compression for natural images but fall short with "simple" images, i.e., images represented by only a small portion of the available intensity values. In this paper we propose a novel image-domain compression technique aiming at simple images, or, more generally, simple regions within a compound image. The proposed method is a context-adaptive bit-plane coder based on a binary arithmetic coder. The context information allows us to exploit the strong correlation across the bit-planes of simple images. Given the bit-plane coding structure our coder produces an SNR-scalable embedded bit stream which can be lossless when completely decoded.
Surface reactions of oxygen ions. 5. Oxidation of alkanes and alkenes by O2- on magnesium oxide (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface reactions of oxygen ions. 5. Oxidation of alkanes and alkenes by O2- on magnesium oxideMasakazu Iwamoto and Jack H. LunsfordCite this: J. Phys. Chem. 1980, 84, 23, 3079–3084Publication Date (Print):November 1, 1980Publication History Published online1 May 2002Published inissue 1 November 1980https://pubs.acs.org/doi/10.1021/j100460a022https://doi.org/10.1021/j100460a022research-articleACS PublicationsRequest reuse permissionsArticle Views319Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A* planning in discrete configuration spaces of autonomous systems (1996)

This thesis presents a powerful, modular framework that uses the A* algorithm to plan motions for an autonomous system. We also introduce Differential A*, a new and complementary method that can be used in the framework for quickly addressing changes in the environment.