gebhart/patrepeval huggingface dataset:
1-Phenylcycloalkylamine derivatives. II. Synthesis and pharmacological activity (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-Phenylcycloalkylamine derivatives. II. Synthesis and pharmacological activityAsher Kalir, Habib Edery, Zvi Pelah, D. Balderman, and Gila PorathCite this: J. Med. Chem. 1969, 12, 3, 473–477Publication Date (Print):May 1, 1969Publication History Published online1 May 2002Published inissue 1 May 1969https://pubs.acs.org/doi/10.1021/jm00303a030https://doi.org/10.1021/jm00303a030research-articleACS PublicationsRequest reuse permissionsArticle Views674Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Controlled Freeze Zone™ for developing sour gas reserves (2011)

The Controlled Freeze Zone™ technology removes CO2 and H2S from natural gas in a single step cryogenic distillation process. Removal and management of acid gas impurities from natural gas pose significant challenges in developing sour gas fields. In many cases CFZ™ is capable of processing sour gases with a wide range of CO2 and H2S compositions at a lower cost than conventional technologies. The acidic components are removed as a high pressure liquid that can be injected into reservoirs for geosequestration or, when of suitable composition, to improve oil recovery. In either case, sulfur production from H2S and release of CO2 to the atmosphere can be eliminated. CFZ™ technology was successfully demonstrated through earlier pilot plant operations. Currently, ExxonMobil Upstream Research Company is advancing CFZ™ to large scale commercial readiness through a commercial demonstration plant in Wyoming, USA. By building the commercial demonstration plant at ExxonMobil’s world-class Shute Creek gas treating and acid gas injection facility, integration of CFZ™ with acid gas injection, will also be demonstrated when the unit is operated in 2010–2011.
Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus. (1994)

Pemphigus vulgaris (PV) is an autoimmune blistering disease, in which autoantibodies against PV antigen (PVA or Dsg3) play a pathogenic role in inducing blister formation. Bacterial fusion proteins of PVA failed to absorb pathogenic autoantibodies from PV patients' sera probably because they did not represent the proper conformation. Therefore, a chimeric protein, PVIg, consisting of the whole extracellular domain of PVA and the constant region of human IgG1, was produced in either in COS7 or in insect Sf9 eucaryotic cells. Both PVIg-COS7 and PVIg-Sf9 were recognized by all of the 35 PV sera tested, but not by any of 10 pemphigus foliaceus (PF), 16 Brazilian PF, 10 bullous pemphigoid, or five normal control sera. Incubation of PV patients' sera with PVIg-Sf9 removed heterogeneous autoantibodies and significantly reduced their immunofluorescence titers on normal human epidermis, although PVIg-Sf9 did not affect the titers of PF sera at all. Furthermore, PVIg-Sf9 absorbed pathogenic autoantibodies from patients' sera and prevented gross blister formation in a neonatal mouse model for pemphigus. These results indicate that this baculovirus product has the proper conformation of the authentic PVA and that its conformation is important in pathogenicity of pemphigus.
Optical quasicylindrical waves at dielectric interfaces (2011)

Much effort has been recently devoted to the study of the electromagnetic field launched on a metal-dielectric interface by one-dimensional (1D) subwavelength indentations. In this work, we consider the wave launched on a semiconductor surface that does not support any surface modes, in contrast to the metallic case. Through analytical calculations performed for polarized 2D Dirac line sources, we show that the waves launched by the two orthogonal polarizations (parallel and perpendicular to the surface) have approximately the same form, differing only in phase and magnitude. This finding implies that the wave launched on the surface by an arbitrary subwavelength indentation under an arbitrary illumination, either at grazing, normal, or oblique incidence, is always the same and possesses universal characteristics. We further observe this wave on a silicon substrate with a near-field probe. Through fitting with a simple model, the measured field is found to exhibit characteristics that are reminiscent of quasicylindrical waves on metal surfaces.
Synthesis of Some Substituted Biphenyls (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Some Substituted BiphenylsRussell Melby, Robert K. Brown, and Reuben B. SandinCite this: J. Am. Chem. Soc. 1950, 72, 2, 1032Publication Date (Print):February 1, 1950Publication History Published online1 May 2002Published inissue 1 February 1950https://pubs.acs.org/doi/10.1021/ja01158a513https://doi.org/10.1021/ja01158a513research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Automatic re-contouring in 4D radiotherapy (2006)

Delineating regions of interest (ROIs) on each phase of four-dimensional (4D) computed tomography (CT) images is an essential step for 4D radiotherapy. The requirement of manual phase-by-phase contouring prohibits the routine use of 4D radiotherapy. This paper develops an automatic re-contouring algorithm that combines techniques of deformable registration and surface construction. ROIs are manually contoured slice-by-slice in the reference phase image. A reference surface is constructed based on these reference contours using a triangulated surface construction technique. The deformable registration technique provides the voxel-to-voxel mapping between the reference phase and the test phase. The vertices of the reference surface are displaced in accordance with the deformation map, resulting in a deformed surface. The new contours are reconstructed by cutting the deformed surface slice-by-slice along the transversal, sagittal or coronal direction. Since both the inputs and outputs of our automatic re-contouring algorithm are contours, it is relatively easy to cope with any treatment planning system. We tested our automatic re-contouring algorithm using a deformable phantom and 4D CT images of six lung cancer patients. The proposed algorithm is validated by visual inspections and quantitative comparisons of the automatic re-contours with both the gold standard segmentations and the manual contours. Based on the automatic delineated ROIs, changes of tumour and sensitive structures during respiration are quantitatively analysed. This algorithm could also be used to re-contour daily images for treatment evaluation and adaptive radiotherapy.
Evaluation of tactual displays for flight control (1973)

Manual tracking experiments were conducted to determine the suitability of tactual displays for presenting flight-control information in multitask situations. Although tracking error scores are considerably greater than scores obtained with a continuous visual display, preliminary results indicate that inter-task interference effects are substantially less with the tactual display in situations that impose high visual scanning workloads. The single-task performance degradation found with the tactual display appears to be a result of the coding scheme rather than the use of the tactual sensory mode per se. Analysis with the state-variable pilot/vehicle model shows that reliable predictions of tracking errors can be obtained for wide-band tracking systems once the pilot-related model parameters have been adjusted to reflect the pilot-display interaction.
Molecular Cloning of kpcA Gene Encoding a Kex2p-like Endoprotease from Aspergillus nidulans (2001)

We cloned and sequenced a gene, kpcA (Kex2p-like proprotein convertase A), from a genomic library of Aspergillus nidulans. The kpcA gene encodes an 820-residue protein, named KpcA, which contains a putative subtilisin-like catalytic domain (residues 136-466) homologous to that of the subtilisin serine protease family. KpcA shows 56, 73, and 47% amino acid identities with Saccharomyces cerevisiae Kex2p, Aspergillus niger KexB, and mouse furin within the subtilisin-like catalytic domain, respectively. The sequences around the proposed active site Asp, His, and Ser residues of KpcA are similar to those of other Kex2p family members. The KpcA mRNA transcript with an expected size of approximately 2.8 kb was detected in A. nidulans. The substrate specificity of KpcA, expressed in CHO cells, is similar to that of A. niger KexB and yeast Kex2p. We conclude that KpcA is a resident Kex2p-like proprotein that processes endoprotease in A. nidulans.
Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism (2018)

A substantial number of individuals have long-lasting adverse effects from a traumatic brain injury (TBI). Depression is one of these long-term complications that influences many aspects of life. Depression can limit the ability to return to work, and even worsen cognitive function and contribute to dementia. The mechanistic cause for the increased depression risk associated with a TBI remains to be defined. As TBI results in chronic neuroinflammation, and priming of glia to a secondary challenge, the inflammatory theory of depression provides a promising framework for investigating the cause of depression following a TBI. Increases in cytokines similar to those seen in depression in the general population are also increased following a TBI. Biomarker levels of cytokines peak within hours-to-days after the injury, yet pro-inflammatory cytokines may still be elevated above physiological levels months-to-years following TBI, which is the time frame in which post-TBI depression can persist. As tumor necrosis factor α and interleukin 1 can signal directly at the neuronal synapse, pathophysiological levels of these cytokines can detrimentally alter neuronal synaptic physiology. The purpose of this review is to outline the current evidence for the inflammatory hypothesis of depression specifically as it relates to depression following a TBI. Moreover, we will illustrate the potential synaptic mechanisms by which tumor necrosis factor α and interleukin 1 could contribute to depression. The association of inflammation with the development of depression is compelling; however, in the context of post-TBI depression, the role of inflammation is understudied. This review attempts to highlight the need to understand and treat the psychological complications of a TBI, potentially by neuroimmune modulation, as the neuropsychiatric disabilities can have a great impact on the rehabilitation from the injury, and overall quality of life.
Cortical thymocyte differentiation in thymomas: an immunohistologic analysis of the pathologic microenvironment. (1987)

Four monoclonal antibodies (BH11, T2/30, AG3, and BC3) were produced against different epithelial components of the normal thymus. An immunohistologic study was performed on 13 thymomas by the use of these and other stromal and lymphocyte-specific reagents. The aim of this study was to find possible relationships between the proliferating thymoma epithelial cell type and the T cell composition of thymomas. Our results indicate that cortical T cell differentiation is present in thymomas, and that this differentiation is induced in the absence of detectable levels of MHC class II antigens on the epithelial component in most cases. The role of the MHC class II antigens cannot be excluded, however, because these antigens were always present on macrophages. Analysis of the selected group of thymomas, each of which contained epithelial cells homogeneously stained by at least one of the described monoclonal antibodies, showed that the cortical type T cell inducer capacity of thymomas is independent of the epithelial type predominant in the tumor.
Polymerase Exchange During Okazaki Fragment Synthesis Observed in Living Cells (2011)

DNA replication machineries have been studied extensively, but the kinetics of action of their components remains largely unknown. We report a study of DNA synthesis during replication in living Escherichia coli cells. Using single-molecule microscopy, we observed repetitive fluorescence bursts of single polymerase IIIs (Pol IIIs), indicating polymerase exchange at the replication fork. Fluctuations in the amount of DNA-bound single-stranded DNA-binding protein (SSB) reflect different speeds for the leading- and lagging-strand DNA polymerases. Coincidence analyses of Pol III and SSB fluctuations show that they correspond to the lagging-strand synthesis and suggest the use of a new Pol III for each Okazaki fragment. Based on exchanges involving two Pol IIIs, we propose that the third polymerase in the replisome is involved in lagging-strand synthesis.
Dynamic Network Surgery for Efficient DNNs (2016)

Deep learning has become a ubiquitous technology to improve machine intelligence. However, most of the existing deep models are structurally very complex, making them difficult to be deployed on the mobile platforms with limited computational power. In this paper, we propose a novel network compression method called dynamic network surgery, which can remarkably reduce the network complexity by making on-the-fly connection pruning. Unlike the previous methods which accomplish this task in a greedy way, we properly incorporate connection splicing into the whole process to avoid incorrect pruning and make it as a continual network maintenance. The effectiveness of our method is proved with experiments. Without any accuracy loss, our method can efficiently compress the number of parameters in LeNet-5 and AlexNet by a factor of $\bm{108}\times$ and $\bm{17.7}\times$ respectively, proving that it outperforms the recent pruning method by considerable margins. Code and some models are available at https://github.com/yiwenguo/Dynamic-Network-Surgery.
Enhanced Peptide Delivery into Cells by Using the Synergistic Effects of a Cell-Penetrating Peptide and a Chemical Drug to Alter Cell Permeability (2015)

Cell-penetrating peptides (CPPs) are short, often hydrophilic peptides that can deliver many kinds of molecules into cells and that are likely to serve as a useful tool of future biotherapeutics. However, CPPs application is limited because of insufficient transduction efficiency and unpredictable cellular localization. Here, we investigated the enhancement of 1,2-benzisothiazolin-3-one (BIT) on the uptake of a synthetic fluorescent TAT and a TAT-conjugated green fluorescent protein (GFP) or pro-apoptotic peptide KLA and evaluated its toxicity in various cell lines. Our results showed that BIT pretreatment can enhance the penetration efficiency of TAT and its fusion peptide. In addition, the fluorescence of the peptide conjugate at effective doses was well-distributed in the intracellular of different cell lines without membrane perforation or detectable cytotoxicity. The internalization of the peptides was serum-dependent and temperature-independent. These findings imply that BIT may serve as a newly found delivery enhancer that is suitable for improving the penetration of CPPs.
Enhancing the radio link protocol for VoIP session establishment signalling over satellite-UMTS (2005)

Session initiation protocol (SIP) is an application layer signalling protocol used in the IP-based UMTS network for establishing multimedia sessions. With a satellite component identified to play an integral role in UMTS, there is a need to support SIP-based session establishment over satellite-UMTS (S-UMTS) as well. Due to the inherent characteristics of SIP, the transport of SIP over an unreliable wireless link with a larger propagation delay is inefficient. To improve the session setup performance, a link layer retransmission, based on radio link control acknowledgement mode (RLC-AM) mechanisms, is utilised. However, the current UMTS RLC-AM procedure is found to cause undesirable redundant retransmission when applied over satellite. As such, the paper proposes an enhancement to the RLC protocol through a timer-based retransmission scheme. Simulation results reveal that not only can the system capacity be improved through this redundant retransmission avoidance scheme, but also better system performances, in terms of session setup delay and failure, are gained.
Reactive Oxygen Species and Signal Transduction (2001)

Increasing evidence suggests a role for intracellular reactive oxygen species (ROS) as mediators of normal and pathological signal transduction pathways. In particular, a growing list of recent reports have demonstrated a rapid and significant increases in intracellular ROS following growth factor or cytokine stimulation. These ROS appear essential for a host of downstream signaling events. Biochemical characterization of this ligand-activated ROS production has revealed important information regarding the molecular composition of the cellular oxidases and the regulation of their activity by small GTPases. Work is proceeding on identifying strategies to identify how ROS might specifically regulate signaling pathways by altering the activity of direct target molecules. This review will focus on the progress in the rapid emerging area of oxidant or redox-dependent signal transduction and speculate how these insights might alter our view and treatment of diseases thought to be caused by oxidative stress.
Blood pressure and lipid lowering effects of terazosin. (1989)

Treatment of hypertension reduces the risk of developing stroke, renal failure and left ventricular failure but not that of coronary heart disease. The reasons for the less favourable results of antihypertensive regimens on coronary heart disease are manifold and unresolved. Antihypertensive treatments which in addition to their blood pressure lowering effects also favourably influence serum lipids offer greater promise to lower coronary heart disease. The long-acting postsynaptic alpha-blocker terazosin was assessed in terms of multifactorial aspects of patients with various risk profiles. The results of clinical trials underline that terazosin changes blood lipids in a beneficial direction and therefore has the potential to lower coronary heart disease more effectively than conventional antihypertensive medications.
Accelerated hydrazone formation in charged microdroplets (2016)

Reaction acceleration in droplets is attributed to solvent evaporation leading to increased surface to volume ratios. An acceleration factor of 10(4) , measured relative to the bulk reaction at short times, is readily achieved by simply increasing the droplet distance of flight showing that the same ionization source can be used to monitor reactions with or without acceleration. Copyright © 2016 John Wiley & Sons, Ltd.
Frame assisted H2O electrolysis induced H2 bubbling transfer of large area graphene grown by chemical vapor deposition on Cu (2013)

An improved technique for transferring large area graphene grown by chemical vapor deposition on copper is presented. It is based on mechanical separation of the graphene/copper by H2 bubbles during H2O electrolysis, which only takes a few tens of seconds while leaving the copper cathode intact. A semi-rigid plastic frame in combination with thin polymer layer span on graphene gives a convenient way of handling- and avoiding wrinkles and holes in graphene. Optical and electrical characterizations prove the graphene quality is better than that obtained by traditional wet etching transfer. This technique appears to be highly reproducible and cost efficient.
Diabetes: complications, prevention and treatment (2011)

Managing patients with diabetes can be challenging; preventing complications and reducing morbidity and mortality are the main treatment goals. Complications of diabetes can be: acute such as diabetic ketoacidosis, hyperosmolar coma and hypoglycaemia; and chronic, including retinopathy, nephropathy, neuropathy and cardiovascular disease. This article will look at the complications, prevention and treatment of diabetes mellitus. The national service framework and Diabetes UK survey will be addressed.
A 3-D super computer architecture (2011)

3D-IC will be the ultimate architecture of the IC design. When it leads to the 3D-Computer, no PCB no package no cable and even no connector are needed. It also has the benefit of small size light weight high speed and less power consumption to meet the global warming regulation. With the 3 dimensional IC circuit design concept a 3-D super computer can be designed with its data signal and instructions processing power millions time faster than the present computer we know of.
Obligate intracellular bacterial parasites of acanthamoebae related to Chlamydia spp (1997)

The phylogeny of obligate intracellular coccoid parasites of acanthamoebae isolated from the nasal mucosa of humans was analyzed by the rRNA approach. The primary structures of the 16S and 23S rRNA molecules of one strain were determined in almost full length. In situ hybridization with a horseradish peroxidase-labeled oligonucleotide probe targeted to a unique signature site undoubtedly correlated the retrieved 16S rRNA sequence to the respective intracellular parasite. This probe also hybridized with the second strain, suggesting a close relationship between the two intracellular parasites. Comparative sequence analysis demonstrated a distinct relationship to the genus Chlamydia. With 16S rRNA similarities of 86 to 87% to the hitherto-sequenced Chlamydia species, the intracellular parasites are likely not new species of this genus but representatives of another genus in the family of the Chlamydiaceae. Consequently, it is proposed to provisionally classify the endoparasite of Acanthamoeba sp. strain Bn9 as "Candidatus Parachlamydia acanthamoebae." From an epidemiological perspective, the results suggest that small amoebae could be environmental reservoirs and vectors for a variety of potentially pathogenic bacteria including members of the Chlamydiaceae.