gebhart/patrepeval huggingface dataset:
Improved accuracy of component alignment with the implementation of image‐free navigation in total knee arthroplasty (2007)

Accuracy of implant positioning and reconstruction of the mechanical leg axis are major requirements for achieving good long-term results in total knee arthroplasty (TKA). The purpose of the present study was to determine whether image-free computer navigation technology has the potential to improve the accuracy of component alignment in TKA cohorts of experienced surgeons immediately and constantly. One hundred patients with primary arthritis of the knee underwent the unilateral total knee arthroplasty. The cohort of 50 TKAs implanted with conventional instrumentation was directly followed by the cohort of the very first 50 computer-assisted TKAs. All surgeries were performed by two senior surgeons. All patients received the Zimmer NexGen total knee prosthesis (Zimmer Inc., Warsaw, IN, USA). There was no variability regarding surgeons or surgical technique, except for the use of the navigation system (StealthStation) Treon plus Medtronic Inc., Minnesota, MI, USA). Accuracy of implant positioning was measured on postoperative long-leg standing radiographs and standard lateral X-rays with regard to the valgus angle and the coronal and sagittal component angles. In addition, preoperative deformities of the mechanical leg axis, tourniquet time, age, and gender were correlated. Statistical analyses were performed using the SPSS 15.0 (SPSS Inc., Chicago, IL, USA) software package. Independent t-tests were used, with significance set at P < 0.05 (two-tailed) to compare differences in mean angular values and frontal mechanical alignment between the two cohorts. To compute the rate of optimally implanted prostheses between the two groups we used the chi(2) test. The average postoperative radiological frontal mechanical alignment was 1.88 degrees of varus (range 6.1 degrees of valgus-10.1 degrees of varus; SD 3.68 degrees ) in the conventional cohort and 0.28 degrees of varus (range 3.7 degrees -6.0 degrees of varus; SD 1.97 degrees ) in the navigated cohort. Including all criteria for optimal implant alignment, 16 cases (32%) in the conventional cohort and 31 cases (62%) in the navigated cohort have been implanted optimally. The average difference in tourniquet time was modest with additional 12.9 min in the navigated cohort compared to the conventional cohort. Our findings suggest that the experienced knee surgeons can improve immediately and constantly the accuracy of component orientation using an image-free computer-assisted navigation system in TKA. The computer-assisted technology has shown to be easy to use, safe, and efficient in routine knee replacement surgery. We believe that navigation is a key technology for various current and future surgical alignment topics and minimal-invasive lower limb surgery.
Ge nFET with high electron mobility and superior PBTI reliability enabled by monolayer-Si surface passivation and La-induced interface dipole formation (2015)

Monolayer-Si-passivated Ge nFETs with high electron mobility (175 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs at Ns=5×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> ) and superior PBTI reliability (max. V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ov</sub> = |V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> | of 0.28V at 125°C) at 0.95-nm-EOT are demonstrated on a 300 mm Si wafer platform. The electron mobility is increased by optimizing the Si thickness while significant improvement in PBTI reliability is realized by band engineering using La-induced interface dipole and defect passivation using laser annealing. This is a significant step forward for the introduction of Ge nFET as high mobility device in advanced technology nodes.
Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes (2019)

Selatogrel was rapidly absorbed following subcutaneous administration in CCS patients, providing prompt, potent, and consistent platelet P2Y12 inhibition sustained for ≥8 h and reversible within 24 h. Further studies of subcutaneous selatogrel are warranted in clinical scenarios where rapid platelet inhibition is desirable.
Biodegradation of monoaromatic hydrocarbons by aquifer microorganisms using oxygen, nitrate, or nitrous oxide as the terminal electron acceptor (1991)

Microcosms were prepared from aquifer material, spiked with monoaromatic hydrocarbons, and amended with oxygen, nitrate, and nitrous oxide. Benzene and alkylbenzenes were degraded to concentrations below 5 micrograms/liter within 7 days under aerobic conditions, whereas only the alkylbenzenes were degraded when either nitrate or nitrous oxide was used. With limited oxygen, monoaromatic hydrocarbons were degraded but removal ceased once oxygen was consumed. However, when nitrate was also present, biodegradation of the alkylbenzenes continued with no apparent lag. Although benzene was still recalcitrant, levels were reduced compared with levels after treatment with nitrate or limited oxygen alone.
IUPHAR-DB: updated database content and new features (2012)

The International Union of Basic and Clinical Pharmacology (IUPHAR) database, IUPHAR-DB (http://www.iuphar-db.org) is an open access, online database providing detailed, expert-driven annotation of the primary literature on human and rodent receptors and other drug targets, together with the substances that act on them. The present release includes information on the products of 646 genes from four major protein classes (G protein-coupled receptors, nuclear hormone receptors, voltage- and ligand-gated ion channels) and ∼3180 bioactive molecules (endogenous ligands, licensed drugs and key pharmacological tools) that interact with them. We have described previously the classification and curation of data for small molecule ligands in the database; in this update we have annotated 366 endogenous peptide ligands with their amino acid sequences, post-translational modifications, links to precursor genes, species differences and relationships with other molecules in the database (e.g. those derived from the same precursor). We have also matched targets with their endogenous ligands (peptides and small molecules), with particular attention paid to identifying bioactive peptide ligands generated by post-translational modification of precursor proteins. Other improvements to the database include enhanced information on the clinical relevance of targets and ligands in the database, more extensive links to other databases and a pilot project for the curation of enzymes as drug targets.
GA approach to scheduling of generator units (2000)

This paper presents a genetic algorithm (GA) approach for solving the generators scheduling problem and modifications are adopted to improve the performance of the GA for the scheduling problem. Solving the problem is able to determine a start-up and shut-down schedule for all available generators in a power system over a period of time to meet the forecasted load demand at minimum cost. From the schedule, near optimum production cost is achieved while satisfying a large set of operating constraints. The operating constraints including fuel cost, start-up costs, minimum start-up time and shutdown time must be met for the generators schedule. Owing to the nonconvex and combinatorial nature of the scheduling problem, conventional programming methods are difficult to solve this problem. However, the application of GA is suitable for solving the problem. GAs are adaptive search techniques to determine the global optimal solution of a combinatorial optimization problem which are based on the mechanics of natural genetics and natural selection.
Tool support for reverse engineering multi-lingual software (2002)

Multi-lingual software systems are those in which the component modules are implemented in multiple languages. Reverse engineering such systems raises several issues, particularly with regard to providing automated tool support for the process. GRASP is a prototype software engineering tool designed to provide visualization of software control structure, complexity, and architecture. The paper describes GRASP and its use in reverse engineering multi-lingual software systems.
Development and Application of a Salmonid EST Database and cDNA Microarray: Data Mining and Interspecific Hybridization Characteristics (2004)

We report 80,388 ESTs from 23 Atlantic salmon (Salmo salar) cDNA libraries (61,819 ESTs), 6 rainbow trout (Oncorhynchus mykiss) cDNA libraries (14,544 ESTs), 2 chinook salmon (Oncorhynchus tshawytscha) cDNA libraries (1317 ESTs), 2 sockeye salmon (Oncorhynchus nerka) cDNA libraries (1243 ESTs), and 2 lake whitefish (Coregonus clupeaformis) cDNA libraries (1465 ESTs). The majority of these are 3' sequences, allowing discrimination between paralogs arising from a recent genome duplication in the salmonid lineage. Sequence assembly reveals 28,710 different S. salar, 8981 O. mykiss, 1085 O. tshawytscha, 520 O. nerka, and 1176 C. clupeaformis putative transcripts. We annotate the submitted portion of our EST database by molecular function. Higher- and lower-molecular-weight fractions of libraries are shown to contain distinct gene sets, and higher rates of gene discovery are associated with higher-molecular weight libraries. Pyloric caecum library group annotations indicate this organ may function in redox control and as a barrier against systemic uptake of xenobiotics. A microarray is described, containing 7356 salmonid elements representing 3557 different cDNAs. Analyses of cross-species hybridizations to this cDNA microarray indicate that this resource may be used for studies involving all salmonids.
Effect of Thermal Annealing on the GaN Metal-Oxide-Semiconductor Capacitors with Gallium Oxide Gate Layer (2010)

In this study, gallium nitride (GaN)-based metal-oxide-semiconductor diodes with a gallium oxide gate layer formed by ac bias-assisted photoelectrochemical oxidation of n-type GaN in were demonstrated. A typical flatband voltage of 4.35 V was obtained by capacitance–voltage measurement. The observed curves shifted toward the negative voltage side when the heterostructures were annealed in ambient oxygen . This result could be tentatively attributed to the fact that the negative effective charges existing in the layer and/or in the interface could be reduced due to the ambient annealing process. A negative value of the effective charge density of , which corresponds to an effective insulator charge number density of around , was obtained.
Safety of synthetic l‐ergothioneine (Ergoneine®) as a novel food pursuant to Regulation (EC) No 258/97 (2016)

Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on synthetic L-ergothioneine, marketed as Ergoneine , as a novel food submitted pursuant to Regulation (EC) No 258/97 of the European Parliament and of the Council. The novel food, synthetic L-ergothioneine, is produced by a one-pot patented manufacturing process. Chemically, L-ergothioneine is a derivative of thiolhistidine, and it is naturally present in a number of foodstuffs such as mushrooms, some varieties of black and red beans, offal and cereals. The production process for the novel food is sufficiently described and does not raise concerns about the safety of the novel food. The information on the composition, specifications, batch-to-batch variability and stability of the novel food is sufficient and does not raise safety concerns. The applicant intends to use the novel food in quantities of up to 5 mg per serving in alcohol-free beverages, cereal bars, milk, fresh dairy products and chocolate. The applicant also proposes to provide the novel food as a food supplement, with a daily dose of up to 30 mg/day for adults and 20 mg/day for children. The target population is children above 3 years of age and the general adult population, except pregnant and breastfeeding women. Considering the NOAEL of 800 mg/kg bw per day, which was based on two subchronic toxicity studies in rats, and the maximum estimated intake levels for L-ergothioneine from all sources, the Panel concludes that the margins of safety of 470 for adults (except pregnant and breastfeeding women) and of 216 for children above 3 years of age are sufficient. The Panel concludes that the novel food, synthetic L-ergothioneine (marketed as Ergoneine ), is safe under the intended conditions of use as specified by the applicant.
An Anatomically Based Model of Transient Coronary Blood Flow in the Heart (2002)

An efficient finite difference model of blood flow through the coronary vessels is developed and applied to a geometric model of the largest six generations of the coronary arterial network. By constraining the form of the velocity profile across the vessel radius, the three-dimensional Navier--Stokes equations are reduced to one-dimensional equations governing conservation of mass and momentum. These equations are coupled to a pressure-radius relationship characterizing the elasticity of the vessel wall to describe the transient blood flow through a vessel segment. The two step Lax--Wendroff finite difference method is used to numerically solve these equations. The flow through bifurcations, where three vessel segments join, is governed by the equations of conservation of mass and momentum. The solution to these simultaneous equations is calculated using the multidimensional Newton--Raphson method. Simulations of blood flow through a geometric model of the coronary network are presented demonstrating physiologically realistic flow rates, washout curves, and pressure distributions.
Novel Aspects in Acute Lymphoblastic Leukemia (2011)

Acute lymphoblastic leukemia (ALL) has turned from a universally fatal to a highly curable disease in little more than four decades. Even though differences in outcome continue to exist between children and adults, intense efforts are under way to overcome this discrepancy and improve the prognosis of adult patients as well. This exemplary progress in ALL therapy has been possible by the combination of an increasingly better understanding of the biology of the disease, availability of a range of effective drugs, and astute designs and relentless executions of many clinical trials. ALL is a complex disease requiring complex therapy. Whereas this book cannot provide a comprehensive review of every one of its many facets, the chapters from many investigators from around the world nevertheless cover a number of relevant topics: aspects of the epidemiology of ALL in Hispanics, ophthalmologic manifestations of ALL, overviews of current therapy and drug-resistance mechanisms, novel biological pathways and targets, new drugs in development, and long-term consequences of CNS prophylaxis and therapy. The publishers and editor therefore hope that the prospective readers will find enough insight and information for their own endeavors.
A Systematic Approach to Synthesizing Multi-Input DC–DC Converters (2009)

The objective of this paper is to propose a general approach for developing multi-input converters (MICs). The derived MICs can deliver power from all of the input sources to the load either individually or simultaneously. By analyzing the topologies of the six basic pulsewidth modulation (PWM) converters, the method for synthesizing an MIC is inspired by adding an extra pulsating voltage or current source to a PWM converter with appropriate connection. As a result, the pulsating voltage source cells (PVSCs) and the pulsating current source cells (PCSCs) are proposed for deriving MICs. According to the presented synthesizing rules, two families of MICs, including quasi-MICs and duplicated MICs, are generated by introducing the PVSCs and the PCSCs into the six basic PWM converters.
Analysis of the GAL3 signal transduction pathway activating GAL4 protein-dependent transcription in Saccharomyces cerevisiae. (1990)

The Saccharomyces cerevisiae GAL/MEL regulon genes are normally induced within minutes of galactose addition, but gal3 mutants exhibit a 3-5-day induction lag. We have discovered that this long-term adaptation (LTA) phenotype conferred by gal3 is complemented by multiple copies of the GAL1 gene. Based on this result and the striking similarity between the GAL3 and GAL1 protein sequences we attempted to detect galactokinase activity that might be associated with the GAL3 protein. By both in vivo and in vitro tests the GAL3 gene product does not appear to catalyze a galactokinase-like reaction. In complementary experiments, Escherichia coli galactokinase expressed in yeast was shown to complement the gal1 but not the gal3 mutation. Thus, the complementation activity provided by GAL1 is not likely due to galactokinase activity, but rather due to a distinct GAL3-like activity. Overall, the results indicate that GAL1 encodes a bifunctional protein. In related experiments we tested for function of the LTA induction pathway in gal3 cells deficient for other gene functions. It has been known for some time that gal3gal1, gal3gal7, gal3gal10, and gal3 rho- are incapable of induction. We constructed isogenic haploid strains bearing the gal3 mutation in combination with either gal15 or pgi1 mutations: the gal15 and pgi1 blocks are not specific for the galactose pathway in contrast to the gal1, gal7 and gal10 blocks. The gal3gal5 and gal3pgi1 double mutants were not inducible, whereas both the gal5 and pgi1 single mutants were inducible. We conclude that, in addition to the GAL3-like activity of GAL1, functions beyond the galactose-specific GAL1, GAL7 and GAL10 enzymes are required for the LTA induction pathway.
Simulation based OPC for contact pattern using 193 nm lithography (2005)

For state of the art technologies, rule based optical proximity correction (OPC) together with conventional illumination is commonly used for contact layers, because it is simple to handle and processing times are short. However, as geometries are getting smaller it becomes more difficult to accurately control critical dimension (CD) variations influenced by nearby pattern. This applies in particular for irregularly arranged contact holes. Here simulation based OPC is more effective. We present a procedure for application of simulation based OPC for a 193 nm lithography contact hole layer with rectangular contact holes of different sizes in different proximities, using attenuated phase shift masks. In order to further improve the accuracy of the simulation based OPC process, characteristics of the mask, like mask corner rounding are incorporated in the OPC process. We build an OPC model, use it for OPC processing of DRAM design data and investigate the process window of the printing contacts. The results show an overlapping process window for length and width of isolated and dense small contact holes of different length and width, which is sufficient for volume production.
Pycnometric vs. densimetric measurements of highly viscous protein solutions (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPycnometric vs. densimetric measurements of highly viscous protein solutionsJ. Bernhardt and H. PaulyCite this: J. Phys. Chem. 1980, 84, 2, 158–162Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/j100439a007https://doi.org/10.1021/j100439a007research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Feedback control framework for car-like robots using the unicycle controllers (2011)

SUMMARY The paper introduces a novel general feedback control framework, which allows applying the motion controllers originally dedicated for the unicycle model to the motion task realization for the car-like kinematics. The concept is formulated for two practically meaningful motorizations: with a front-wheel driven and with a rear-wheel driven. All the three possible steering angle domains for car-like robots—limited and unlimited ones—are treated. Description of the method is complemented by the formal stability analysis of the closed-loop error dynamics. The effectiveness of the method and its limitations have been illustrated by numerous simulations conducted for the three main control tasks, namely, for trajectory tracking, path following, and set-point regulation.
Optimization of the Lactococcus lactis nisin-controlled gene expression system NICE for industrial applications (2005)

Protein production with the NICE gene expression system in L. lactis strongly depends on the medium composition, the fermentation parameters and the amount of nisin added for induction. Careful optimization of key parameters lead to a significant increase in the yield of the target protein.
Die Rückseite des Spiegels (1990)

In den letzten Jahren habe ich meinem Sohn Andrew und seinem Freund oft beim Spielen mit Bauklötzern zugesehen. Bis zu einem bestimmten Alter stapeln Kinder einfach Stein auf Stein, doch dann beginnen sie plötzlich — nach einem von Piaget beschriebenen Entwicklungssprung — Strukturen mit ausgesprochener Links-Rechts-Symmetrie zu konstruieren. Wenn solche Kinder eines Tages zu Architekten herangewachsen sind, werden sie vielleicht Bauwerke errichten, wie sie in den Abbildungen 5, 6 und 7 dargestellt sind. Die ganze Architektur beruht praktisch auf der bilateralen Symmetrie, und asymmetrische Gebäude werden als erklärungsbedürftige Kuriositäten betrachtet. Die Kathedrale von Chartres beispielsweise zeigt eine ausgeprägte Asymmetrie: Ihr Bau dauerte so lange, daß sich in dieser Zeit der Baustil veränderte.
Development of a novel air-back wafer carrier with an integrated endpoint detector for copper CMP application (2003)

This study presents the development of a novel air-back polishing carrier with an integrated Linear Variable Differential Transformer Endpoint Detector (LVDT EPD). In the course of this study, uniformity evaluation was performed on blanket PETEOS oxide and blanket copper wafers and dishing/erosion multi-step polish on patterned wafers. Employment of an air-back polishing carrier resulted in non-uniformity <3% 1/spl sigma/. The LVDT EPD showed an excellent S/N ratio. The combination of LVDT EPD and air-back polishing carrier significantly enhanced the process performance in Cu CMP.