gebhart/patrepeval huggingface dataset:
Abstract 820: Molecular markers for head and neck cancer detection (2010)

Abstract Introduction: Fifty thousand new cases of HNSCC are diagnosed in the United States each year. Unfortunately, most of these cases are advanced and only cured about 40% of the time. Cure rates could reach over 80% if diagnosed in earlier stages. We are developing a simple and inexpensive molecular screening test for the early detection of HNSCC. The markers under investigation are detectable in oral rinses and include soluble CD44 (solCD44), hyaluronic acid (HA) and total protein. Materials and Methods: To study the population most likely to benefit from this early detection test, high-risk controls were identified by their smoking and/or drinking behavior from primary care clinics. They received a complete head and neck exam and had no clinical evidence of malignancy or premalignancy. Low-risk controls were normal volunteers. All subjects completed a detailed questionnaire including demographic, socioeconomic, risk factor and general health information. Oral samples were collected using a previously described swish and gargle method. We performed the solCD44, HA and protein assays in blinded fashion on oral rinses from 18 HNSCC cases, 18 frequency-matched high-risk controls and 21 low-risk controls using previously reported ELISA and ELISA-like assays. Results: We statistically assessed the adequacy of matching between the cases and high-risk controls with respect to age, gender, race, socioeconomic status, tobacco and alcohol exposure and oral health. There were no significant differences between cases and controls for any of these variables except for a borderline significant difference in race. Log2solCD44 levels were significantly higher in cancer cases (2.42 ng/ml) and high-risk controls (2.12 ng/ml) compared to low risk controls (0.64 ng/ml, p&lt;0.05). Log2protein levels were also higher in cancer cases (0.88 mg/ml) and high-risk controls (0.97 mg/ml) compared to low-risk controls (0.52, p&lt;0.05). Following receiver operating curve analysis, the AUC for distinguishing high-risk controls from low-risk controls was 0.94 for solCD44 and 0.82 for protein. The AUC for distinguishing cancer from low-risk controls was 0.95 for solCD44 and 0.77 for protein. After adjusting for race, the AUC for distinguishing cancer from high-risk controls was 0.76 for solCD44 and 0.68 for protein. Both of these were better for the nonwhite group (0.84 for solCD44 and 0.83 for protein). Conclusions: In this preliminary data set, the solCD44 and protein test appear to effectively distinguish HNSCC cases from high and low-risk controls. Race may have an impact on results. Further work including more subjects with longer follow-up must be done to confirm or refute these findings. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 820.
Combination of interferon induction therapy and ribavirin in chronic hepatitis C (2001)

The initial clearance of hepatitis C virus (HCV) during interferon-alfa therapy is dose-dependent. Therefore, higher initial interferon doses (induction therapy) may improve treatment results. This concept was tested in a prospective, randomized controlled trial. Previously untreated patients with chronic hepatitis C were randomized to receive 3 different interferon doses during the first 14 weeks of therapy (Group A, n = 130: 10 MU IntronA [AESCA-Schering Plough, Traiskirchen, Austria]/day for 2 weeks, followed by 10 MU/2 days for 12 weeks; Group B, n = 124: 5 MU/day for 14 weeks; Group C, n = 119; 5 MU/2 days for 14 weeks) followed in all by 5 MU/2 days for 24 weeks. Throughout the whole study all patients received 1 to 1.2 g ribavirin/day. On treatment, no differences in viral clearance rates were observed. Sustained response rates were also not different among the groups (A: 48.5%, B and C: 41.3%, intent to treat). When data were analyzed according to genotypes, sustained response was almost twice as high in patients with genotype 1 receiving high-dose interferon induction therapy (A: 44.2%, B: 28.6%, C: 27%, P <.05). In contrast, results were not different in genotype 3a patients (A: 61.3%, B: 75.9%, C: 56.3%; P >.1). These data indicate that high-dose interferon induction therapy may improve the outcome of interferon/ribavirin combination therapy in genotype 1 patients.
Optimal routing in mixed media networks with integrated voice and data traffic (2003)

A large mixed-media network which consists of a low-delay terrestrial subnetwork and a high-bandwidth satellite subnetwork is considered. Voice and data traffic are transmitted and routed through the same network. It is shown how to route both types of traffic via ground and/or satellite links by means of static, deterministic procedures. Two common voice/data integrated protocols, namely the fixed boundary and the movable boundary schemes, for the satellite channel are investigated, and the performance of both is evaluated. The optimal splitting ratios for voice and data at the SIMPs (Satellite Interface Message Processors) are found using a powerful numerical optimization package, (FSQP).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Comparison of Mydriatic Effect Between Two Drugs of Different Mechanism (2009)

Our study showed that 1% tropicamide, with its parasympathetic antagonistic mechanism of action, was more effective at inducing pupillary dilation than 2.5% phenylephrine, and the combination of 1% tropicamide and 2.5% phenylephrine was more effective than multiple drops of single eye drops.
The PII protein in the cyanobacterium Synechococcus sp. strain PCC 7942 is modified by serine phosphorylation and signals the cellular N-status (1994)

The glnB gene product (PII protein) from Synechococcus sp. has previously been identified among 32P-labeled proteins, and its modification state has been observed to depend on both the nitrogen source and the spectral light quality (N. F. Tsinoremas, A. M. Castets, M. A. Harrison, J. F. Allen, and N. Tandeau de Marsac, Proc. Natl. Acad. Sci. USA 88:4565-4569, 1991). As shown in this study, modification of the PII protein primarily responds to the N-status of the cell, and its light-dependent variations are are mediated through nitrate metabolism. Modification of the PII protein results in the appearance of three isomeric forms with increasing negative charge. Unlike its homolog counterparts characterized so far, PII in Synechococcus sp. is modified by phosphorylation on a serine residue, which represents a unique kind of protein modification in bacterial nitrogen signalling pathways.
LSC 2013 abstract - Defining the bacterial microbiota of adult non-CF bronchiectasis (2013)

Background: Despite its prevalence and contribution to morbidity, the microbiology of non-CF bronchiectasis is poorly defined. We present an in depth, cross-sectional, analysis of the bacteria present in the lower airways in this condition.

Methods: Paired induced sputum and bronchoalveolar lavage samples were obtained from 42 adult non-CF bronchiectasis patients and 16 healthy individuals. The bacterial species in these samples were detailed by 16S rRNA gene pyrosequencing, with meta-analysis use to distinguish 'core' and 'satellite' populations.

Results: Over 140 bacterial species were identified, including those associated with respiratory tract and opportunistic infections. Detected species included many that would be unlikely to be reported through standard diagnostic surveillance, such as those requiring anaerobic conditions for growth. Substantial species overlap was observed for paired samples. A core group of species, detected frequently and in high abundance, was defined. Within this group, Haemophilus influenzae made the greatest contribution to non-CF bronchiectasis sample similarity, though a range of respiratory pathogens and oral cavity species were also detected. A relatively small group of rare and low abundance satellite species were identified. The comparative contribution of core and satellite groups suggests a low level of random species acquisition.

Conclusions: This study has shown a complex and defined bacterial microbiota is present in non-CF bronchiectasis that is distinct from other respiratory contexts, and provides a basis for further investigations into the potential contribution of these bacteria to disease.
A NEW ALGORITHM FOR ADAPTIVE NOISE CANCELLATION USING SINGULAR VALUE DECOMPOSITION (1986)

A new algorithm for noise cacellation using singular value decomposition of matrix is presented in this paper. By this algorithm, the impulse response of an adaptive filter from. an auto-correlation function and cross-correlation function of reference input and primary input is first estimated, and then using singular value decomposition of matrix, the coefficients of the filter is obtained. A recursive algorithm for calculating the impulse response of the adaptive filter is also (presented. Simulation results illustrate the behavior of the algorithm.
Design of metal oxide nanoparticles: Control of size, shape, crystalline structure and functionalization by aqueous chemistry (2010)

The aim of this paper is to show that a very simple but well controlled chemistry in an aqueous medium allows one to efficiently control the main characteristics of oxide nanoparticles. Examples concerning titania, alumina, iron and manganese oxides are discussed to illustrate various effects on the control of size, shape and structure of nanoparticles. Some examples of functionalization of these particles are also illustrated. Experimental data, procedures and detailed references can be found in the cited literature.
Cellulose/DNA Hybrid Nanomaterials (2009)

Cellulose nanocrystals (CNXLs) have drawn attention from researchers for their remarkable reinforcing abilities and excellent mechanical properties. CNXLs typically have high aspect ratios of around 20-50 (length/width), low density of around 1.6 g/cc, high stiffness (135 to 155 GPa), and strength (estimated at 7500 MPa). Here we utilize CNXLs in a bottom-up hierarchical assembly to produce a macroscale material. Single-stranded oligonucleotides with an amino modifier were successfully grafted on CNXLs. The molecular recognition ability of the oligomeric base pairs was then utilized by duplexing complementary oligonucleotides grafted onto separate CNXL populations. The resulting hybrid nanomaterials were analyzed using dynamic light scattering, atomic force microscopy, and UV spectroscopy.
Optical Spatial Filtering with the Least Mean-Square-Error Filter* (1969)

Experimental studies dealing with the restoration of photographic images by optical spatial-filtering techniques are reported. The spatial filters are of a class incorporating predictions of optimum-filtering theory in the presence of random additive noise. This theory was derived using the criterion of least-mean-square error. Measured-modulation-transfer-function curves of both filtered and unfiltered scenes are presented, as well as restorations of continuous tone and binary (Sayce) images distorted by linear motion during exposure. Results show that this type of filtering is superior to that of the infinite signal-to-noise-ratio spatial filter.
Urological Endoscopic Surgery Under Local Anesthesia: A Cost-Reducing Idea (1984)

With the new resectoscope injection needle adequate local anesthesia was obtained in 81 selected patients who underwent transurethral incision and resection of the prostate, visual urethrotomy, ureteral meatotomy, and resection of primary and recurrent bladder tumors, as well as for the immediate relief of postoperative pain when transurethral resection of the prostate was performed with the patient under general anesthesia.
Expression of Lymphocytes and Lymphocyte Subsets in Patients with Severe Acute Respiratory Syndrome (2003)

In a cohort of 38 patients with severe acute respiratory syndrome (SARS), we observed leukopenia in 47% of patients, lymphopenia in 84%, and T lymphopenia in 95%. CD4(+) T lymphocyte levels were reduced in 100% of patients, CD8(+) T lymphocyte levels were reduced in 87%, B lymphocyte levels were reduced in 76%, and natural killer cell levels were reduced in 55%. Our data suggested that these patients' immune systems were impaired during the course of SARS. The absolute counts of lymphocyte subsets demonstrated a clinical significance for patients with SARS.
Chemical model studies on the mutagenesis of benzofuran dioxetanes in the Ames test: evidence for the benzofuran epoxide as ultimate mutagen (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical model studies on the mutagenesis of benzofuran dioxetanes in the Ames test: evidence for the benzofuran epoxide as ultimate mutagenW. Adam, L. Hadjiarapoglou, T. Mosandl, C. R. Saha-Moeller, and D. WildCite this: J. Am. Chem. Soc. 1991, 113, 21, 8005–8011Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/ja00021a029https://doi.org/10.1021/ja00021a029research-articleACS PublicationsRequest reuse permissionsArticle Views385Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Properties of ultralow energy boron implants using octadecaborane (2008)

The material properties of junctions formed by implanting ultralow energy octadecaborane (B18H22+) followed by spike and flash annealings are reported. Along with providing significant drift mode beam current improvements at sub-1-keV energies, the B18H22 implants form an amorphous layer due to the large mass of the material. The authors have found that the thickness of the amorphous layer is dependent on the beam current of the implant, and that upon millisecond annealing, results in a shallow junction that is free of end-of-range damage. The authors have also investigated other issues critical to integrating B18H22 into standard complementary metal-oxide semiconductor processing. Dose retention and sputtering of silicon have been examined using secondary-ion-mass spectroscopy for implants ranging from 50eVto2keV. Of considerable concern is the ability to effectively strip photoresist from wafers without removing dopant that is placed within 1–2nm of the surface. The use of fluorine-free downstream ashing in combination with proper wet-cleaning techniques is shown to minimize undesirable dopant loss from the cleaning process.
(Hexamethylbenzene)ruthenium(II) complexes: synthesis and coordination chemistry of a novel tridentate ligand with an O,O,Cl-donor set (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(Hexamethylbenzene)ruthenium(II) complexes: synthesis and coordination chemistry of a novel tridentate ligand with an O,O,Cl-donor setWolfgang Klaeui and Elke BuchholzCite this: Inorg. Chem. 1988, 27, 20, 3500–3506Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/ic00293a014https://doi.org/10.1021/ic00293a014research-articleACS PublicationsRequest reuse permissionsArticle Views280Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of Race of Attractiveness Ratings and Individuals Physical Attractiveness Stereotypes (2014)

The purpose of this research project was to investigate the “physical attractiveness stereotype”. Previous research suggests that the physical attractiveness plays an important role in how we ascribe certain personality traits. Weiten (2002) for example, noted the stereotype as people’s tendency “to ascribe socially desirable personality traits to individuals who are considered to be more attractive, seeing them as more sociable, poised, and well adjusted than those who are less attractive”. However, very little research has been conducted to explore the role race may have on the concept. The current study was conducted to explore the validity of the physical attractiveness stereotype and determine how influential the role of race may be. In this study, twelve subjects were given a series of cards, each with four pictures on them, and were asked to match certain personality traits (some positive and some negative) to the pictures that were presented on the cards. The pictures on the cards actually represented people of different race and varying attractiveness. Data was then collected and analyzed to determine if race can in fact influence the physical attractiveness stereotype.
Synthesis and characterization of a new fluorescent probe for measuring potassium (1990)

A new fluorescent probe, 6,7-(4-methyl)coumaro-[2.2.2] cryptand, has been developed for measuring K+. This compound was made by fusing [2.2.2] cryptand with 4-methylcoumarin through 2 ethoxy bridges at the 6 and 7 positions. The probe has a fluorescent excitation peak at 340 nm and an emission peak at 420 nm. In aqueous solutions, increasing the K+ concentration from 0 to 10 mM causes the fluorescence intensity to increase by 143%. The dissociation constant (Kd) for K+ in aqueous solutions is 1.9 mM. In 100% methanol, the Kd for K+ decreases to 0.012 mM, making it possible to measure K+ concentrations in the micromolar range. Na+, tetramethylammonium, NH4+, Ca2+, and Mg2+ have a minimal affect on the fluorescence of the probe in the absence of K+. The coefficient of variation for the measurement of K+ by use of this new dye is less than 1%. In this report, the synthetic procedure is described and the spectral properties of the probe are characterized. Experiments are described demonstrating the use of this probe 1) in measuring K+ in aqueous solutions from 0 to 10 mM and in a microfluorometric assay to measure K+ from 0.0005 to 0.003 mM and 2) in monitoring K+ transport in rabbit proximal tubule brush-border membrane vesicles.
Growth of thick CdTe films by close-space-sublimation technique (2005)

High resistivity CdTe thick films (50 to 300µm) have been deposited by using close-space-sublimation technique with very high growth rate of about 5-10 µm/min. In certain deposition conditions, bulk-like free-standing thick films are obtained. The resistivity of deposited films is in the order of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> Ωcm without any intentional doping. The current voltage characteristic shows a typical space charge limited behavior at bias voltages higher than 1 V. The effective hole mobility of 0.2 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs is estimated. In addition, the films show clear photo-response to short laser pulse excitation, indicating feasibility for X-ray imaging devices.
Metabotropic glutamate type 5, dopamine D<sub>2</sub> and adenosine A<sub>2a</sub> receptors form higher‐order oligomers in living cells (2009)

G protein-coupled receptors are known to form homo- and heteromers at the plasma membrane, but the stoichiometry of these receptor oligomers are relatively unknown. Here, by using bimolecular fluorescence complementation, we visualized for the first time the occurrence of heterodimers of metabotropic glutamate mGlu(5) receptors (mGlu(5)R) and dopamine D(2) receptors (D(2)R) in living cells. Furthermore, the combination of bimolecular fluorescence complementation and bioluminescence resonance energy transfer techniques, as well as the sequential resonance energy transfer technique, allowed us to detect the occurrence receptor oligomers containing more than two protomers, mGlu(5)R, D(2)R and adenosine A(2A) receptor (A(2A)R). Interestingly, by using high-resolution immunoelectron microscopy we could confirm that the three receptors co-distribute within the extrasynaptic plasma membrane of the same dendritic spines of asymmetrical, putative glutamatergic, striatal synapses. Also, co-immunoprecipitation experiments in native tissue demonstrated the existence of an association of mGlu(5)R, D(2)R and A(2A)R in rat striatum homogenates. Overall, these results provide new insights into the molecular composition of G protein-coupled receptor oligomers in general and the mGlu(5)R/D(2)R/A(2A)R oligomer in particular, a receptor oligomer that might constitute an important target for the treatment of some neuropsychiatric disorders.
Purification and structural characterization of bacillomycin F produced by a bacterial honey isolate active against<i>Byssochlamys fulva</i>H25 (2008)

The antifungal compound produced by a bacterial strain isolated from honey was determined to be stable over a broad pH range and was stable to heat treatments up to 100 degrees C. This is the first report of honey microflora producing bacillomycin F or any antifungal compound.