gebhart/patrepeval huggingface dataset:
[Establishment of immuno-PCR technique for the detection of tumor associated antigen MG7-Ag on the gastric cancer cell line]. (1994)

The gastric cancer associated antigen McAb MG7-Ag was detected by means of a newly established method, termed immuno-PCR. A McAb-recombinant DNA chimeric molecule was made which possesses bispecific binding affinity for antigen that had been immobilized on microtiter wells and the segment of the attached DNA was amplified by PCR. The antigen of gastric cancer cell line KATO III was monitored by this method. Analysis of PCR products by agarose gel electrophoresis after staining with ethidium bromide allowed as few as 20 cells to be detected readily and reproducibly. Immuno-PCR showed a 10(4) enhancement in detection sensitivity compared with ELISA assay. When the same numbers of cells (2 x 10(6)/ml) were immobilized and then the serial diluted chimeric molecule was added, 3.8 x 10(-14) moles and 3.0 x 10(-11) moles were needed to give positive results with the immuno-PCR and ELISA assay, respectively. Therefore, immuno-PCR could give an enormous amplification capability with good specificity, and has a sensitivity much higher than any existing techniques for antigen detection.
Thermal properties of commercial thermoelectric modules (2002)

This paper shows the results of testing two commercial thermoelectric modules, one is the typical 12 V, Tmax=80/spl deg/C and the other, designed for high temperature, is a 50 W, Tmax=200/spl deg/C. All the results have been obtained experimentally using a test bench designed and built for this purpose. Special procedures were applied in order to be able to control the temperature in both sides of the thermoelectric module during the experiments. A description of the test bench (which is very easy to build for any laboratory) and the procedures for testing modules in a convenient way are also included. The results obtained correspond to a wide range of working conditions: a temperature from -15/spl deg/C to 190/spl deg/C, a range of heat power from 10 W to 50 W, and electric power from 0.1 W to 80 W.
Comparative morphology of changeable skin papillae in octopus and cuttlefish (2013)

A major component of cephalopod adaptive camouflage behavior has rarely been studied: their ability to change the three-dimensionality of their skin by morphing their malleable dermal papillae. Recent work has established that simple, conical papillae in cuttlefish (Sepia officinalis) function as muscular hydrostats; that is, the muscles that extend a papilla also provide its structural support. We used brightfield and scanning electron microscopy to investigate and compare the functional morphology of nine types of papillae of different shapes, sizes and complexity in six species: S. officinalis small dorsal papillae, Octopus vulgaris small dorsal and ventral eye papillae, Macrotritopus defilippi dorsal eye papillae, Abdopus aculeatus major mantle papillae, O. bimaculoides arm, minor mantle, and dorsal eye papillae, and S. apama face ridge papillae. Most papillae have two sets of muscles responsible for extension: circular dermal erector muscles arranged in a concentric pattern to lift the papilla away from the body surface and horizontal dermal erector muscles to pull the papilla's perimeter toward its core and determine shape. A third set of muscles, retractors, appears to be responsible for pulling a papilla's apex down toward the body surface while stretching out its base. Connective tissue infiltrated with mucopolysaccharides assists with structural support. S. apama face ridge papillae are different: the contraction of erector muscles perpendicular to the ridge causes overlying tissues to buckle. In this case, mucopolysaccharide-rich connective tissue provides structural support. These six species possess changeable papillae that are diverse in size and shape, yet with one exception they share somewhat similar functional morphologies. Future research on papilla morphology, biomechanics and neural control in the many unexamined species of octopus and cuttlefish may uncover new principles of actuation in soft, flexible tissue.
A determinant of bone architecture. The minimum effective strain. (1983)

Minimum effective strain (MES), a hypothesis since 1964, has achieved experimental support. The range is about 0.0008-0.002 unit bone surface strain. Strains below the MES apparently do not evoke adaptive architectural bone modeling, but those above it do. As a key property of living lamellar bone and its intermediary organization, MES offers the potential to predict exactly when and where mechanical loads will cause bone architectural adaptations. MES represents a step toward the goal of constructing a specific, predictive, and quantitative theory of the mechanical determinants of skeletal architecture.
Morphological Basis of Directional Sensitivity of the Outer Hair Cells in the Organ of Corti (1962)

Electron-microscope studies of cross sections of hair bundles on the outer hair cells in the organ of Corti show a consistent orientation of the sensory hairs. In the cuticle, a basal body is regularly found on the side of the cell toward the Hensen's cells. The sensory hairs are organized in the shape of w pointing towards the basal body. The morphological polarization of the hair cells in the organ of Corti is discussed in the light of similar polarization of the hair cells in the vestibular sensory epithelia and the lateral-line canal organs. A close relation is to be found between the morphological and electrophysiological polarization of the mechanoreceptors in the sense organs of hearing and equilibrium.
A Moral Voice for the Restoration Lady: A Comparative View of Allestree and Vives (1986)

Following the civil strife of the 1640s and the Interregnum of the 1650s, Anglican England felt the necessity of spiritual housecleaning to tighten its hold on the godly and to ferret out dissenting influences. Evidence of renewed authoritarianism is seen in Richard Allestree's early appointment in the 1660s as a lecturer for the city of Oxford, where his task was to establish the faith and to root out schismatical opinions propagated by "false" teachers of the Interregnum. In 1662 Charles was to pass measures, albeit reluctantly, requiring strict conformity concerning practices in the church not unlike those enforced by Laud. The surplice and the organ re-entered the church at Oxford and adherence to a stricter prayer book was a requisite for a preacher's position in the church. Further, the two thousand "schismatics" who were ejected at this time were, in 1665, forbidden to come within five miles of their former parishes. As Nicholas Jose has stated in his recent book on "ideas" of the Restoration, The backlash against the rule of the saints, and even against the moderate presbyterians who, despite their loyalism, were suspiciously regarded as instigators of the rebellion, was triumphant, forceful and authoritarian...(21).
Digital television: Transmission and coding (1985)

Digital television involves a wide range of coding requirements along the television chain, from picture source to home receiver. All parts of this chain are likely to become digital in some future. This paper concentrates on systems descriptions, state of the present developments of equipments, and state of the international discussions. The production and related activities are first considered (CCIR world standard, parallel and serial interfaces, digital video-tape recorder). Then, the structure of the television systems for mid and long-distance transmission links are presented. Complementing this system approach, we recall some general aspects related to television coding: specificity of television pictures and sequences, properties of the human visual system, aspects of optimization procedures. The results obtained for television signals by intraframe and interframe bit-rate reduction coding techniques are presented. The paper then considers the links of the television chain closer to the user: digital broadcasting and local distribution. The last part is devoted to some aspects of compatibility for coding and transmission standards taking into account their compatibility along the TV system chain and between alternative distribution situations or other picture services that will ultimately come to the user's TV set.
High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics (2013)

The ever-increasing speed and resolution of modern microscopes make the storage and post-processing of images challenging and prevent thorough statistical analyses in developmental biology. Here, instead of deploying massive storage and computing power, we exploit the spherical geometry of zebrafish embryos by computing a radial maximum intensity projection in real time with a 240-fold reduction in data rate. In our four-lens selective plane illumination microscope (SPIM) setup the development of multiple embryos is recorded in parallel and a map of all labelled cells is obtained for each embryo in <10 s. In these panoramic projections, cell segmentation and flow analysis reveal characteristic migration patterns and global tissue remodelling in the early endoderm. Merging data from many samples uncover stereotypic patterns that are fundamental to endoderm development in every embryo. We demonstrate that processing and compressing raw image data in real time is not only efficient but indispensable for image-based systems biology.
Influence of the Arene Ligand, the Number and Type of Metal Centers, and the Leaving Group on the<i>in Vitro</i>Antitumor Activity of Polynuclear Organometallic Compounds (2009)

Dinuclear ruthenium complexes were shown to exhibit strong antiproliferative properties in human tumor cell lines. In order to extend the structure−activity relationships (SARs), a series of new RuII(arene)X complexes (X = Cl, Br, I) linked by pyridinone-based spacers were synthesized and assayed for their in vitro antineoplastic effect. The SARs were established in terms of the arene ligand, the leaving group (the halide ligand), and the nature and number of the metal centers. It was demonstrated that, besides the previously shown effect of the spacer length, the nature of the metal center has the biggest influence on the in vitro anticancer activity. The halide ligand had no effect on the cytotoxicity, due to rapid formation of the same aquation product for all evaluated compounds. Furthermore, nearly identical activity was observed when varying the arene ligand from p-cymene to biphenyl. However, the number of metal centers was found to be important, with the dinuclear compound being more active than the analogous mono- and trinuclear species.
Lesion detection of electronic gastroscope images based on multiscale texture feature (2012)

Electronic gastroscope has been playing an important role in the examination of gastrointestinal tract. However, due to its great dependence on the doctor's experience and skills, the rate of misdiagnosis is still high. Therefore, an automatic lesion detection system is a huge help for doctors. In this paper, we design a new scheme for gastroscopic image lesion detection. Two new multiscale texture features are utilized and compared which combine contourlet transform with gray level co-occurrence matrix (GLCM) and local binary pattern (LBP) respectively. Combined with color feature and with AdaBoost as a classifier, experiments show that it is promising to utilize the proposed scheme to detect lesions in gastroscopic images. The best performance comes from the combination of color feature and contourlet based local binary pattern feature with false negative rate of 11.94%, false positive rate of 16.10%, and error rate of 13.99%.
Daily Subcutaneous Administration of Human Growth Hormone in Growth Hormone Deficient Children (1986)

Sixteen children (10 boys, 6 girls) on treatment for some years with i.m. injections twice or thrice weekly of human growth hormone (hGH; Crescormon Kabi Vitrum), participated in a prospective study. The weekly amount of hGH (8, 12, or 16 IU) was kept the same in each child, but divided into daily (7) s.c. injections at bedtime. The growth rate increased in all children during the first year on s.c. daily hGH (5.3 to 7.4 cm/year; 1.95 to 4.27 SDS). This increased growth rate did not persist during the second year on daily s.c. hGH, but an increased growth rate did not persist during the second year on daily s.c. hGH, but an increased predicted final height was found. The plasma profile of hGH was followed: i.m. injected hGH gave mostly a high (200 mU/l) plasma level of some hours (wide intra- and interpatient variation), and s.c. injected hGH a lower max level of longer duration (wide inter patient variation). The daily s.c. regimen of hGH was extremely well accepted by the children and their parents and no GH-antibodies or other adverse effects were found. We recommend daily s.c. injection of hGH as an alternative in the treatment of GH-deficient children.
Double Hysteresis Loop of BaTi<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>at the Curie Point (1953)

It is known that the Curie point $\ensuremath{\theta}$ of the ferroelectric BaTi${\mathrm{O}}_{3}$ shifts to higher temperatures when a dc bias field is applied. If the crystal shows a sharp transition, we expect by applying an ac field at the Curie temperature that the crystal would become alternately ferroelectric and nonferroelectric in the cycle of the ac field. This can be seen in the shape of the hysteresis loop at temperatures slightly above $\ensuremath{\theta}$. In the center of the polarization $P$ versus field $E$ plot, we observe a linear behavior corresponding to the paraelectric state of BaTi${\mathrm{O}}_{3}$ above $\ensuremath{\theta}$. At both high voltage ends, however, we observe a hysteresis loop corresponding to the ferroelectric state. A change in temperature causes a change in size and shape of the double hysteresis loops, ranging from a line with curves at the ends (higher temperature) to two overlapping loops (lower temperature). The results obtained allow us to calculate the different constants in the free-energy expression of Devonshire and Slater. One of the results shows that the transition is of the first order since the ${P}^{4}$ term turns out to be negative. The properties of the hysteresis loops are discussed, especially the large spontaneous electrical polarization and the low coercive field strength.
Battle‐scarred pancreas: Role of alcohol and pancreatic stellate cells in pancreatic fibrosis (2006)

Pancreatic stellate cells (PSC) are now recognized as the key mediators of pancreatic fibrosis, a characteristic feature of chronic pancreatitis. The role of PSC in alcoholic pancreatic fibrosis has been examined in vivo (using pancreatic tissue from patients with alcohol-induced chronic pancreatitis and from animal models of experimental pancreatitis) and in vitro (using PSC in culture). These studies indicate that PSC are activated early in the course of pancreatic injury and are the predominant source of collagen in the fibrotic pancreas. The factors responsible for mediating PSC activation during chronic alcohol exposure include ethanol, its metabolite acetaldehyde, oxidant stress and cytokines (released during episodes of alcohol-induced pancreatic necroinflammation). Most recently, the intracellular signaling mechanisms regulating ethanol-induced PSC activation have been identified and include the mitogen-activated protein kinase (MAPK) pathway, phosphatidylinositol-3-kinase (PI3K) and protein kinase C (PKC), and the transcription factor activator protein-1 (AP-1).
Polyurethane foam process development. A systems engineering approach (1972)

Abstract A seven‐step systems engineering approach is described and applied to the integral‐skin foam system. Through the use of a hybrid computer simulation of a dynamic mathematical model, the two process variables with the greatest lever on the skin‐forming process are determined. These data are then utilized to develop a new foam concept which makes it possible to control skin thickness and core foam density independently.
Optical Properties of a New Nonlinear Optical Material: Tl_3AsSe_3 (1972)

We report on the synthesis and the measurement of the properties of large single crystals of a new synthetic nonlinear optical material of the sulfosalt type, Tl(3)AsSe(3). The crystal space group is R3m; the refractive indices range from 3.14 to 3.44 with n(0) - n(e) = 0.18 (negative uniaxial), and the material is transparent from 1.26 microm to beyond 17 microm. The nonlinear optical susceptibilities are of the order of three times those of Ag(3)AsS(3) (proustite), in reasonable agreement with Miller's rule, and the measured phase-match angle for frequency doubling of the CO(2) laser output (10.6 microm) is theta(m) = 22 +/- 2 degrees . Calculations of tuning curves for parametric oscillation indicate the possibility of angle tuning over the entire transparency range of the crystal; pumping at 2.06 microm (Ho(3+)-doped YAG or SOAP) appears to be a promising technique for obtaining efficient tunable parametric oscillation in the 3-5-microm region.
Genetic, structural and functional properties of an IgG DNA-binding monoclonal antibody from a lupus patient with nephritis (1998)

Antibodies binding to double-stranded (ds) DNA are strongly associated with renal involvement in patients with systemic lupus erythematosus (SLE). We have generated two new IgG DNA-binding monoclonal antibodies (mAb), RH-14 and DIL-6, from the peripheral blood lymphocytes of two SLE patients with glomerulonephritis using the heteromyeloma cell line CB-F7. RH-14 is an IgG1 lambda antibody which also bound to single-stranded DNA, histones and nucleosomes. DIL-6 is an IgG3 lambda antibody with restricted antigen binding specificity. cDNA encoding the variable regions of the heavy (V(H)) and light (V(L)) chains of RH-14 was sequenced and the antigen binding site of this mAb was computer modelled. Sequence analysis of V(H) and V(L) regions of RH-14 showed that V(H) is derived from germ-line gene V3-7, a member of the V(H)3 family, and V(L) is derived from DPL 11, a member of the V(lambda)2 family. Somatic mutations and basic amino acid residues are identified in the complementarity-determining regions of both V(H) and V(L) regions. The nephritogenic properties of these mAb were analyzed by implanting and growing the hybridoma cells secreting the mAb in the peritoneum of SCID mice. The animals that received the RH-14 hybridoma produced higher levels of proteinuria (3 to > or = 4) (p < 0.001) compared to the groups that received DIL-6 (trace to > or = 1) or CB-F7 (trace). Electron microscopy of kidney sections from all the RH-14-implanted animals showed granular immunoglobulin deposition in the renal glomerular capillaries and mesangium. In this study we have shown for the first time using electron microscopy that a human IgG anti-dsDNA mAb, RH-14, is nephritogenic and that deposition of such an antibody alone is sufficient to induce renal damage.
Multilayer holographic data multiplexing with random encoded reference beam (1999)

In this paper we demonstrate the scheme for volume holographic data multiplexing by using the features of shift selectivity of a random encoded speckle reference wave. The proposed recording method results in a more efficient use of the recording medium volume and increases the storage density in comparison with spherical or plane-wave reference beams. The mechanism of lateral and longitudinal shift selectivity are described theoretically and shown to agree with experimental measurements for holographic data multiplexing in the volume of the FetLiNbCE crystal.
Weakly Supervised Dense Event Captioning in Videos (2018)

Dense event captioning aims to detect and describe all events of interest contained in a video. Despite the advanced development in this area, existing methods tackle this task by making use of dense temporal annotations, which is dramatically source-consuming. This paper formulates a new problem: weakly supervised dense event captioning, which does not require temporal segment annotations for model training. Our solution is based on the one-to-one correspondence assumption, each caption describes one temporal segment, and each temporal segment has one caption, which holds in current benchmark datasets and most real-world cases. We decompose the problem into a pair of dual problems: event captioning and sentence localization and present a cycle system to train our model. Extensive experimental results are provided to demonstrate the ability of our model on both dense event captioning and sentence localization in videos.
Treatment of Hyperlipemia in Diabetic Patients on Dialysis with a Physiological Substance (1991)

Hyperlipemia is a very frequent complication of the diabetic patient on dialysis. There is difficulty of treatment with the diet, because the dietary restriction already imposed on these patients and the secondary effects and toxicity of the available drugs in uremics aggravate the problem. We have treated 22 diabetic patients on dialysis (8 on hemodialysis and 14 on continuous ambulatory peritoneal dialysis) suffering from hyperlipemia with pantethine, a physiological substance and coenzyme A precursor in the Krebs cycle. With the administration of an oral dose of 900 mg/day we obtained a reduction of total cholesterol (275 +/- 72 vs. 231 +/- 54 mg/dl; p less than 0.001), very-low-density lipoprotein (VLDL)-cholesterol (66 +/- 36 vs. 46 +/- 18 mg/dl; p less than 0.01) and triglycerides (332 +/- 182 vs. 227 +/- 90 mg/dl; p less than 0.01) at 2 months. High-density lipoprotein (HDL)-cholesterol did not change, but the total cholesterol/HDL-cholesterol ratio decreased significantly (p less than 0.05). Total cholesterol, VLDL and triglycerides showed a progressive and significant reduction at 4 and 6 months. No changes were observed in serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, uric acid, blood glucose and glycosylated hemoglobin. Gastric discomfort in 2 patients and pruritus in another one were the secondary effects related. Pantethine was shown to be a very effective hypolipemic agent in diabetic patients on dialysis with a great tolerance.
Radioimmunoassay of Serum Levels of Luteinizing Hormone Throughout the Estrous Cycle in Pigs (1970)

A double antibody radioimmuno-assay has been developed to measure porcine luteinizing hormone (LH). Porcine follicle-stimulating hormone, porcine thyroid-stimulating hormone, or the components of serum per se did not appear to influence the assay. The levels of LH could be reliably measured at any time during the estrous cycle in 200 x002F;l of serum. A peak in serum levels of LH occurred on the day of estrus when blood samples were obtained at daily intervals. The peak in levels of LH coincided with the onset of estrus when serum samples were collected and checks for estrus were made at 4-hr intervals. (Endocrinology 87: 576, 1970)
A high resolution physical map of 2.5 Mbp of the Down syndrome region on chromosome 21 (1994)

The region surrounding D21S55 in band 21q22 of human chromosome 21 has been implicated in the etiology of Down syndrome (DS). In this paper, we report the construction of a high resolution map of a 2.5 Mb region around the marker D21S55. Characterization of YAC clones by accurate size determination, end isolation and marker assignment was used to build a refined YAC-based map. The YAC clones were then used to isolate 284 cosmid clones, covering 2.3 Mb, from a chromosome 21-specific cosmid library. The cosmid clones were ordered into overlapping groups and a restriction map of each group was determined. The groups of cosmids were then ordered and oriented with respect to the YAC-based map. This high resolution map provides the framework for further analysis of the region by transcribed sequence mapping and sequence determination.