gebhart/patrepeval huggingface dataset:
Analysis of a Sugar Response Mutant of Arabidopsis Identified a Novel B3 Domain Protein That Functions as an Active Transcriptional Repressor (2005)

A recessive mutation hsi2 of Arabidopsis (Arabidopsis thaliana) expressing luciferase (LUC) under control of a short promoter derived from a sweet potato (Ipomoea batatas) sporamin gene (Spo(min)LUC) caused enhanced LUC expression under both low- and high-sugar conditions, which was not due to increased level of abscisic acid. The hsi2 mutant contained a nonsense mutation in a gene encoding a protein with B3 DNA-binding domain. HSI2 and two other Arabidopsis proteins appear to constitute a novel subfamily of B3 domain proteins distinct from ABI3, FUS3, and LEC2, which are transcription activators involved in seed development. The C-terminal part of HSI2 subfamily proteins contained a sequence similar to the ERF-associated amphiphilic repression (EAR) motif. Deletion of the C-terminal portion of HSI2 lost in the hsi2 mutant caused reduced nuclear targeting of HSI2. Null allele of HSI2 showed even higher Spo(min)LUC expression than the hsi2 mutant, whereas overexpression of HSI2 reduced the LUC expression. Transient coexpression of 35SHSI2 with Spo(min)LUC in protoplasts repressed the expression of LUC activity, and deletion or mutation of the EAR motif significantly reduced the repression activity of HSI2. These results indicate that HSI2 and related proteins are B3 domain-EAR motif active transcription repressors.
The Impact of Driver Inattention on Near-Crash/Crash Risk: An Analysis Using the 100-Car Naturalistic Driving Study Data (2006)

The purpose of this report was to conduct in-depth analyses of driver inattention using the driving data collected in the 100-Car Naturalistic Driving Study. An additional database of baseline epochs was reduced from the raw data and used in conjunction with the crash and near-crash data identified as part of the original 100-Car Study to account for exposure and establish near-crash/crash risk. The analyses presented in this report are able to establish direct relationships between driving behavior and crash and near-crash involvement. Risk was calculated (odds ratios) using both crash and near-crash data as well as normal baseline driving data for various sources of inattention. The corresponding population attributable risk percentages were also calculated to estimate the percentage of crashes and near-crashes occurring in the population resulting from inattention. Additional analyses involved: driver willingness to engage in distracting tasks or driving while drowsy; analyses with survey and test battery responses; and the impact of driver’s eyes being off of the forward roadway. The results indicated that driving while drowsy results in a four- to six-times higher near-crash/crash risk relative to alert drivers. Drivers engaging in visually and/or manually complex tasks have a three-times higher near-crash/crash risk than drivers who are attentive. There are specific environmental conditions in which engaging in secondary tasks or driving while drowsy is more dangerous, including intersections, wet roadways, and areas of high traffic density. Short, brief glances away from the forward roadway for the purpose of scanning the driving environment are safe and actually decrease near-crash/crash risk. Even in the cases of secondary task engagement, if the task is simple and requires a single short glance the risk is elevated only slightly, if at all. However, glances totaling more than 2 seconds for any purpose increase near-crash/crash risk by at least two times that of normal, baseline driving.
THE UTILISATION OF AN EMBRYO BREEDER TECHNIQUE FOR MATURATION OF SOMATIC EMBRYOS (1998)

The formation of embryos from somatic tissue may require several transfers to different media before ripe embryos can be harvested. In a semiopen system, where fresh medium is delivered continuously to the cells through a semipermeable membrane, the problem of repeated transfer can be avoided or the number of transfers reduced. Two types of culture vessels were constructed for studying the growth and differentiation of cells on the membrane. Because cells and embryos are stationary, not moving around as in shaking cultures, it is called an embryo breeder (EB) system. This equipment allows culture periods of unlimited duration without transfer of cultured tissues and any kind of changes in nutrient composition during the culture period. In addition, selection of a membrane with an appropriate molecular weight cut-off (MWCO) enables control of molecule transfer through the membrane. The first prototype was made of Teflon® and the second one of polycarbonate. Both EBs are autoclavable and consist of upper and lower compartments separated by a semipermeable membrane. The cells to be cultured are located in the upper compartment and the nutrients are pumped slowly by a tubing pump through the lower compartment. In preliminary experiments, EBs were loaded with carrot somatic cells and globular embryos. During the culture period of 2 to 4 weeks, differentiation of so-called torpedo-stage embryos with clearly visible shoot and root initials could be observed.
Species‐specific<i>in vitro</i>pharmacological effects of the cannabinoid receptor 2 (CB<sub>2</sub>) selective ligand AM1241 and its resolved enantiomers (2007)

These findings constitute the first in vitro functional assessment of R,S-AM1241 at rodent CB(2) receptors and the first characterization of the AM1241 enantiomers in recombinant cell systems and in vivo. The greater antinociceptive efficacy of S-AM1241, the functional CB(2) agonist enantiomer of AM1241, is consistent with previous observations that CB(2) agonists are effective in relief of pain.
Personalized search using identity-based hashing (2008)

This paper presents a method to retrieve shared information on tagging systems more easily using ordinary search engines. This paper focuses on sharing multimedia data, such as photos and videos, and describes a method of personalized searches with privacy protection by using an identity-based hashing function. Secure implementation and seamless integration into current search services, without any changes, are also described. That is, this method can be used in the current computing environment. Evaluations showed that the additional storage requirement is only 10% and that the system responds in 10 seconds with 1000 dummy results for anonymization.
EINE MITTELTRAEGER-STABBOGENBRUECKE UEBER DIE SALZACH (1970)

UEBER DIE SALZACH WURDE SUEDLICH VON SALZBURG EINE AUTOBAHNBRUECKE MIT EINEM EINZIGEN STABBOGEN (LANGERSCHER BALKEN) ALS HAUPTTRAGSYSTEM FERTIGGESTELLT. DIE BRUECKE BESTEHT AUS DEM 133,5 METER WEIT GESPANNTEN STAEHLERNEN STABBOGENTRAGWERK UND DEN BEIDERSEITS ANSCHLIESSENDEN 26,7 METER LANGEN VORLANDBRUECKEN AUS SPANNBETON, DIE ALS DURCHLAUFTRAEGER UEBER JE 2 FELDER AUSGEBILDET SIND. DER MITTELTRAEGERBOGEN DES STAHLTRAGWERKES IST AN DEN ENDEN MIT DEM VERSTEIFUNGSTRAEGER BIEGESTEIF VERBUNDEN. DIE SEITLICHE ABSTUETZUNG DES BOGENS UND DIE EINLEITUNG DER LOTRECHTEN LASTEN ERFOLGT DURCH BIEGESTEIFE HAENGEPFOSTEN, WELCHE IHRERSEITS IN DEN TORSIONSKASTEN, BESTEHEND AUS DECK, VERSTEIFUNGSTRAEGER UND UNTEREM VERBAND, UEBER STARKE QUERVERBAENDE EINGESPANNT SIND. DA SICH JEDER LASTFALL IN EINEN SYMMETRISCHEN UND ANTIMETRISCHEN TEILZUSTAND ZERLEGEN LAESST, UEBERNIMMT DER SCHIEF GELAGERTE VERSTEIFUNGSTRAEGER 3 TRAGFUNKTIONEN. (A*).
Tailoring Mesopores in Monolithic Macroporous Silica for HPLC (2000)

Mesopore formation in silica gels having continuous macropores has been investigated. The macroporous wet silica gel prepared by the sol-gel process including phase separation was aged in a basic solvent making use of hydrolysis of urea in a closed condition. The mesopore structure was finally obtained by subsequent evaporation drying of solvent and heat-treatment at 600°C for 2 h. The dissolution-reprecipitation kinetics at the interfaces between wet gel skeletons and an external solvent affected the size and volume of pores formed within the skeletons. Below 120°C, mesopores suitable for various chromatographic applications have been formed typically within 24 h. On the other hand, at 200°C, the pore size attained the macropore dimensions (>50 nm), and the whole macroporous morphology was significantly modified.
Excited-State Proton Transfer in Indigo (2017)

Excited-state proton transfer (ESPT) in Indigo and its monohexyl-substituted derivative (Ind and NHxInd, respectively) in solution was investigated experimentally as a function of solvent viscosity, polarity, and temperature, and theoretically by time-dependent density functional theory (TDDFT) calculations. Although a single emission band is observed, the fluorescence decays (collected at different wavelengths along the emission band using time-correlated single photon counting (TCSPC)) are biexponential, with two identical decay times but different pre-exponential factors, which is consistent with the existence of excited-state keto and enol species. The femtosecond (fs)-transient absorption data show that two similar decay components are present, in addition to a shorter (<3 ps) component associated with vibrational relaxation. From TDDFT calculations it was shown that with both Ind and NHxInd, the reaction proceeds through a single ESPT mechanism driven by an Arrhenius-type activation through a saddle point, which is enhanced by tunneling through the barrier. From the temperature dependence of the steady-state and time-resolved fluorescence data, the activation energy for the process was found to be ∼11 kJ mol<sup>-1</sup> for Ind and ∼5 kJ mol<sup>-1</sup> for NHxInd, in close agreement with the values calculated by TDDFT: 12.3 kJ mol<sup>-1</sup> (Ind) and 3.1 kJ mol<sup>-1</sup> (NHxInd). From time-resolved data, the rate constants for the ESPT process in dimethyl sulfoxide were found to be 9.24 × 10<sup>10</sup> s<sup>-1</sup> (Ind) and 7.12 × 10<sup>10</sup> s<sup>-1</sup> (NHxInd). The proximity between the two values suggests that the proton transfer mechanism in indigo is very similar to that found in NHxInd, where a single proton is involved. In addition, with NHxInd, the TDDFT calculations, together with the viscosity dependence of the fast component, and differences in the activation energy values between the steady-state and time-resolved data indicate that an additional nonradiative process is involved, which competes with ESPT. This is attributed to rotation about the central carbon-carbon bond, which brings the system close to a conical intersection (CI). The CI is of the sloped type, where the seam is reached through an OH stretching vibration.
New challenges in content dissemination networks (2008)

Recent changes in the production and use of multimedia content have fostered development of new ways to distribute this material to consumers. In particular, the increasing demand for this content has led to the design and deployment of new content distribution networks. The latest examples of these networks take advantage of new technological underpinnings. For example, they typically make use of larger, less expensive storage, and many incorporate peer-to-peer distribution technologies. The key challenges in designing this new generation of content distribution networks involve responding to changes in not only memory and network resources, but also content availability and popularity. This letter discusses the key design constraints for modern content distribution networks and some of the ways that these constraints can be met by innovative combinations of resource control algorithms. It also describes how a simulation environment is used to analyze some of these techniques in the context of video distribution requirements.
Expression of p57/Kip2 Protein in Hepatocellular Carcinoma (2001)

Evaluation of the biological character of carcinomas requires understanding of cell cycle regulators. In the present study, we investigated the expression of p57 (Kip2) in 90 hepatocellular carcinomas and 66 noncancerous lesions. The average p57 labeling index in noncancerous lesions was 72.3 +/- 19.7. The labeling index significantly decreased (p < 0.0001) in hepatocellular carcinoma (54.9 +/- 19.7). It was significantly lower in hepatocellular carcinoma cases with high biological aggressiveness such as advanced stage (p = 0.0041), poor differentiation (p < 0.0001), larger size (p = 0.0400), portal invasion (p < 0.0001), satellite tumor (p = 0.0023), high proliferating activity (p = 0.0002) and cyclin D(1) overexpression (p = 0.0416). Furthermore, cases with low p57 expression showed worse outcomes for disease-free survival in univariate analysis (p = 0.0235), although p57 expression could not be recognized as an independent prognostic factor. These findings suggest that p57 contributes to the downregulation of cell proliferation and to the progression of hepatocellular carcinoma.
Sorption of amiodarone to polyvinyl chloride infusion bags and administration sets (1985)

The loss of amiodarone from i.v. admixtures to flexible polyvinyl chloride (PVC) infusion bags and i.v. administration sets was studied. Admixtures containing amiodarone hydrochloride 600 micrograms/mL and either 5% dextrose injection or 0.9% sodium chloride injection were stored at room temperature in glass bottles (both with and without contact of the drug solution with the rubber bottle closure), in flexible PVC bags, or in rigid PVC bottles. After 120 hours, the contents of each flexible PVC bag were emptied and replaced by methanol, which was allowed to remain in the bag for an additional 120 hours and was then analyzed for amiodarone content. To determine availability of amiodarone after infusion through a 1.8-m PVC i.v. administration set, solutions stored in glass containers were run through the set at 0.5 mL/min for 90 minutes. Samples of drug solutions were collected at appropriate intervals and analyzed by a stability-indicating high-performance liquid chromatography (HPLC) assay. Admixtures containing 0.9% sodium chloride injection were not stable; visual incompatibility was evident after 24 hours of storage in glass bottles, and no further testing was performed. In admixtures containing 5% dextrose injection that were stored in 50-mL flexible PVC bags, 60% of the initial amiodarone concentration remained after 120 hours; approximately half of the lost drug was recovered with the methanol. In effluent collected from the PVC administration set, 82% of the initial amiodarone concentration remained. Amiodarone concentrations did not decrease appreciably, after storage in glass or rigid PVC bottles, indicating that drug loss was probably affected by the plasticizer, di-2-ethylhexyl phthalate.(ABSTRACT TRUNCATED AT 250 WORDS)
Measurement of low-noise column readout circuits for CMOS image sensors (2006)

This brief describes the measurement results of high-gain column readout circuits for CMOS image sensors. The measurement results show that the double-stage noise-canceling architecture has better noise performance than that of the single-stage architecture at a first-stage gain of greater than 6. The lowest input-referred noise is measured to be 49 muVrms at a gain of 24
On Addressing the Nation in a Time of War: Two Approaches (1969)

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CCD Photometric Study of the Contact Binary TX Cnc in the Young Open Cluster NGC 2632 (2007)

Abstract TX Cnc is a member of the young open cluster NGC2632. In the present paper, four CCD epochs of light minimum and a complete $V$ light curve of TX Cnc are presented. A period investigation based on all available photoelectric or CCD data showed that it is superimposed on a long-term increase ($dP/dt=+3.97\times{10^{-8}}$d yr$^{-1}$), and weak evidence suggests that it includes a small-amplitude period oscillation ($A_3=0\rlap{.}^{\rm d} 0028$; $T_3=26.6$yr). The light curves in the $V$ band obtained in 2004 were analyzed with the 2003 version of the W-D code. It was shown that TX Cnc is an overcontact binary system with a degree of contact factor $f=24.8\% (\pm0.9\%)$. The absolute parameters of the system were calculated: $M_1=1.319\pm0.007M_{\odot}, M_2=0.600\pm0.01M_{\odot}$; $R_1=1.28\pm0.19R_{\odot}, R_2=0.91\pm0.13R_{\odot}$. TX Cnc may be on the TRO-controlled stage of the evolutionary scheme proposed by Qian (2001a, b, 2003a), and may contain an invisible tertiary component ($m_3\approx0.097M_{\odot}$). If this is true, the tertiary component has played an important role in the formation and evolution of TX Cnc by removing angular momentum from the central system (Pribulla & Rucinski 2006). In this way the contact binary configuration can be formed in the shortlife time of a young open cluster via AML.
Gibberellins Promote Flowering of Arabidopsis by Activating the <i>LEAFY</i> Promoter (1998)

The gibberellin class of plant hormones has been implicated in the control of flowering in several species. In Arabidopsis, severe reduction of endogenous gibberellins delays flowering in long days and prevents flowering in short days. We have investigated how the differential effects of gibberellins on flowering correlate with expression of LEAFY, a floral meristem identity gene. We have found that the failure of gibberellin-deficient ga1-3 mutants to flower in short days was paralleled by the absence of LEAFY promoter induction. A causal connection between these two events was confirmed by the ability of a constitutively expressed LEAFY transgene to restore flowering to ga1-3 mutants in short days. In contrast to short days, impairment of gibberellin biosynthesis caused merely a reduction of LEAFY expression when plants were grown in long days or with sucrose in the dark. As a first step toward identifying other small molecules that might regulate flowering, we have developed a rapid in vitro assay for LEAFY promoter activity.
Statistical shape model-based reconstruction of a scaled, patient-specific surface model of the pelvis from a single standard AP x-ray radiograph (2010)

It is feasible to reconstruct a scaled, patient-specific surface model of the pelvis from single standard AP x-ray radiograph using the present approach. The unknown scale of the reconstructed model can be estimated by performing a surface-based 3D/3D matching.
Beyond acid suppressants in gastro-oesophageal reflux disease (2001)

See article on page 364 

The burden of gastro-oesophageal reflux disease becomes apparent when one considers that treatment with acid suppressants accounts for a significant proportion of our national healthcare budget.1 Oh et al present evidence in this issue of Gut 2that a novel antioxidant substance (DA-9601) significantly attenuates the severity of oesophageal inflammation in a rat model of oesophagitis (see page 364). Furthermore, they demonstrated that DA-9601 was more effective in the prevention of oesophagitis than physiological concentrations of ranitidine.2 

However, before we start prescribing antioxidants for gastro-oesophageal reflux disease, several factors need to be considered. Firstly, it is not clear why the authors chose to compare antioxidants with H2 antagonists rather than with proton pump inhibitors. Large randomised controlled trials of oesophagitis suggest that whereas after eight weeks of treatment H2antagonists achieve complete healing in up to 60% of patients, proton pump inhibitors achieve endoscopically proved healing in approximately …
Resistance against <i>Trypanosoma cruzi</i> associated to anti-living trypomastigote antibodies. (1982)

A dissociation between antibodies involved in the diagnosis of Trypanosoma cruzi infections and those participating in resistance against this parasite is reported. Mice immunized with different T. cruzi antigens (frozen-thawed culture forms, glutaraldehyde-fixed blood trypomastigotes, "metabolic antigens" from blood parasites, and surface glycoprotein from epimastigotes) present only antibodies detected by conventional immunofluorescence tests (IFA) using fixed parasites. However, mice chronically infected with T. cruzi harbor both reactive IFA antibodies and antibodies against living blood forms (ALBA) detectable by complement-mediated lysis (CML). Challenge of the various groups of animals with virulent T. cruzi show that only mice presenting ALBA are strongly resistant. In addition, the antibody lytic activity is lost in mice parasitologically cured after specific treatment. Those findings strongly suggest that ALBA are good markers for monitoring protection in experiments of vaccination against T. cruzi. They also support our previous suggestion that the search for antibodies against living blood forms, detected mainly by CML, is an important element in establishing a reliable criterion of cure in human Chagas' disease.
Effect of Conductive Additives and Surface Fluorination on the Electrochemical Properties of Lithium Titanate (Li[sub 4/3]Ti[sub 5/3]O[sub 4]) (2010)

The effect of conductive additives and surface fluorination on the charge/discharge behavior of was investigated. Mixtures of acetylene black (AB) and vapor-grown carbon fiber (VGCF) gave larger first charge capacities at a high current density of 600 mA/g than those obtained when AB or VGCF was used as a conductive additive by improving the electric contact between particles and a nickel current collector. The surface fluorination of by improved the thermal stability of the electrolyte solution without decreasing first charge capacities and first coulombic efficiencies.
Patients with active Crohn's disease have elevated serum antibodies to antigens of seven enteric bacterial pathogens. (1984)

A variety of bacterial pathogens including Campylobacter, Yersinia, Listeria, Brucella, and Mycobacteria have been suggested as potential etiologic agents for Crohn's disease. To assess the role of these organisms we studied responses to eight antigens in sera from patients with active Crohn's disease and healthy age- and sex-matched controls. In complement-fixation assays, the sera from the Crohn's disease patients had enhanced reactivity compared with the control sera to all seven orally ingested pathogens studied; however, only the difference in distribution of titers to Yersinia pseudotuberculosis was statistically significant (p less than 0.0025). There was no difference between the two groups in reactivity to arabinomannan, a common mycobacterial antigen. Seroreactivity to enteric pathogens not resident in the bowel flora probably represents a nonspecific sensitization to cross-reacting antigens. Lack of response to the mycobacterial antigen suggests that widespread mycobacterial disease with high bacillary load is not present in Crohn's disease.
Stability of refrigerated and frozen solutions of tropisetron in either polyvinylchloride or polyolefin infusion bags (1997)

Tropisetron (50 microg/ml) in either 0.9% sodium chloride or 5% dextrose is chemically stable in polyvinylchloride or polyolefin bags for at least 3 months when stored in a refrigerator or in a frozen state.
Spatial pyramid mining for logo detection in natural scenes (2008)

This work introduces a novel data mining scheme, spatial pyramid mining, to discover association rules at multiple resolutions in order to identify frequent spatial configurations of local features that correspond to classes of logos appearing in real world scenes. By indexing representative examples by the mined rules we can efficiently detect a variety of different lettering or design marks associated with a brand. Features in an image are marked by matching rules to representative examples selected via a weighted cosine similarity measure. Logos are localized in an image via density-based clustering of matched features. Precision vs. recall curves are presented for experiments on a dataset of web images of nearly 1,000 images containing seven popular logo types.