gebhart/patrepeval huggingface dataset:
Microwave processing of WC-Co composities and ferroic titanates (1997)

The innovations in microwave processing of ceramics have been dominated to date by serendipitous discovery, because the interaction between such radiation as delivered via available tools and the materials of widely varying properties, sizes, and shapes is so complex that it has defied quantitative analysis. For over 10 years a wide variety of inorganic ceramic and semiconducting materials have been synthesized, sintered, and reacted in our own labs, including microwave hydrothermal synthesis of metals, ferrites, and electroceramic phases. These local results are summarized and used as the reference point for reporting on two different new advances: sintering of WC-Co composite tool bits and other similar objects in under 15 min, while retaining extremely fine microstructures, without any grain growth inhibitors; using reduced TiO2 or Ta2O5 for the synthesis of phases such as BaTiO3, Ba3MgTa2O9, and Pb(Zr.Ti)O3 in a few minutes in a 2.45 GHz field at the astonishing temperatures of 300–700 °C.
XEVENTS/XMESSAGES: Application Events and Messaging Framework for Grid (2002)

Computational Grids have gained dominance in large scale scientific and engineering research. They enable researchers to collaborate and solve problems by providing seamless access to pervasive collection of computing resources. One of the requirements in Grid computing is the need to monitor interconnected components that are part of a distributed scientific application. Event based systems pose an elegant and robust solution to make this possible. An event can be described as a message containing typed data generated by a source and delivered to any listener interested in events of that type. It may contain additional information like timestamp or sequence number used by the application or used for message management. Events can be broadly classified into two categories: lower level events such as middleware or system events and higher level events like application events. The system events are typically built into the services layer of the framework being used by the Grid application. For instance, a component may generate an event upon its instantiation or connection to another component. Events used to monitor network or host performance, as in the case of Network Weather Service (NWS), also constitute middleware events. Application events disseminate application-specific information like file activity or application state transition. In this paper, we address the following research questions: 1. How does one design a Grid-based event system that is compatible with web-services? 2. What are the design features we require to make the event delivery robust and reliable? 3. How can existing standards like SOAP/XML be leveraged to our advantage? 4. Is the system extensible and flexible enough to interoperate with diverse systems? 5. Can we construct and API simple enough to use without constricting the functionality? 6. What additional features, such as filtering and logging, would be useful to the user? In addition to satisfying the answers posed by the above questions, it would increase the credibility if such an event system has been deployed and used with distributed applications. We shall demonstrate the design of such an event system and exhibit its use in Grid applications.
Manifold Based Dynamic Texture Synthesis from Extremely Few Samples (2014)

In this paper, we present a novel method to synthesize dynamic texture sequences from extremely few samples, e.g., merely two possibly disparate frames, leveraging both Markov Random Fields (MRFs) and manifold learning. Decomposing a textural image as a set of patches, we achieve dynamic texture synthesis by estimating sequences of temporal patches. We select candidates for each temporal patch from spatial patches based on MRFs and regard them as samples from a low-dimensional manifold. After mapping candidates to a low-dimensional latent space, we estimate the sequence of temporal patches by finding an optimal trajectory in the latent space. Guided by some key properties of trajectories of realistic temporal patches, we derive a curvature-based trajectory selection algorithm. In contrast to the methods based on MRFs or dynamic systems that rely on a large amount of samples, our method is able to deal with the case of extremely few samples and requires no training phase. We compare our method with the state of the art and show that our method not only exhibits superior performance on synthesizing textures but it also produces results with pleasing visual effects.
High moment FeCoNi alloy thin films fabricated by pulsed-current electrodeposition (2001)

Soft, high moment FeCoNi thin films were fabricated by pulsed-current electrodeposition, in which the period with current flow was in the range 0.5-20 s and period with no current flow in the range 0-30 s. Film composition is determined by two concurrent phenomena, anomalous codeposition and diffusion-limited reduction of Fe, whose relative importance can be controlled by adjusting the duration of the current pulses. For short current pulses and long intervals between pulses the anomalous deposition process dominates and the films are Fe-rich. Under these conditions, the ratio of BCC/FCC phases is also higher, which increases the saturation magnetization of the film. For long current pulses and short intervals between pulses the diffusion of Fe/sup 2+/ ions in the electrolyte dominates the reduction reaction. Correspondingly, the films are Ni-rich and the ratio of BCC/FCC phases is reduced.
Synthesis of Platensimycin (2008)

In modern drug discovery, antibodies or libraries of simple synthetic organic compounds, mostly of heterocyclic origin, are favored. Natural products play an increasingly inferior role as they are considered structurally too complex, limited in quantity, and difficult to synthesize, manipulate, and derivatize. Thus it was a sensation when a Merck research group reported that classical screening of metabolites from Streptomyces platensis has unearthed a low-molecular-weight organic compound with remarkable antibiotic properties.
Functional treatment of clubfoot: a new series of 350 idiopathic clubfeet with long-term follow-up (2004)

A new series of 350 previously unreported cases of clubfoot treated by the functional method are reported. One hundred and eighteen clubfeet were unilateral and 116 were bilateral. The follow-up ranged from 11 to 18 years, with an average of 14 years. The improvements in the technique of physical therapy increased the rate of good results up to 77% compared with our previously published series. In an effort to objectively compare these results with other series, the authors assessed all clubfeet using the "at birth classification" published in 1995. Outcome evaluation was performed when the patients were 6 years old, and final evaluation at the end of growth of the foot. This is the first major series to be assessed according to such objective criteria, as much before the inception of treatment as at the end of growth. The results of this new series have been compared with those obtained in our former series.
The poems of Filicaja (1942)

Journal Article The poems of Filicaja Get access Frederic Connett White Frederic Connett White Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 183, Issue 7, 26 September 1942, Pages 195–196, https://doi.org/10.1093/nq/183.7.195b Published: 26 September 1942
Re-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA (2020)

According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century. No information regarding the ends of genomes was presented, and they are important to understand the evolutionary relationship of the different smallpox vaccine genomes during the centuries. We re-assembled the genomes, which include the largest genomes in the vaccinia lineage and one true horsepox strain. Moreover, the assemblies reveal a diverse genetic structure in the genome ends. Our data emphasize the concurrent use of horsepox and horsepox-related viruses as the smallpox vaccine in the nineteenth century.
Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer (2018)

TTK protein kinase (TTK), also known as Monopolar spindle 1 (MPS1), is a key regulator of the spindle assembly checkpoint (SAC), which functions to maintain genomic integrity. TTK has emerged as a promising therapeutic target in human cancers, including triple-negative breast cancer (TNBC). Several TTK inhibitors (TTKis) are being evaluated in clinical trials, and an understanding of the mechanisms mediating TTKi sensitivity and resistance could inform the successful development of this class of agents. We evaluated the cellular effects of the potent clinical TTKi CFI-402257 in TNBC models. CFI-402257 induced apoptosis and potentiated aneuploidy in TNBC lines by accelerating progression through mitosis and inducing mitotic segregation errors. We used genome-wide CRISPR/Cas9 screens in multiple TNBC cell lines to identify mechanisms of resistance to CFI-402257. Our functional genomic screens identified members of the anaphase-promoting complex/cyclosome (APC/C) complex, which promotes mitotic progression following inactivation of the SAC. Several screen candidates were validated to confer resistance to CFI-402257 and other TTKis using CRISPR/Cas9 and siRNA methods. These findings extend the observation that impairment of the APC/C enables cells to tolerate genomic instability caused by SAC inactivation, and support the notion that a measure of APC/C function could predict the response to TTK inhibition. Indeed, an APC/C gene expression signature is significantly associated with CFI-402257 response in breast and lung adenocarcinoma cell line panels. This expression signature, along with somatic alterations in genes involved in mitotic progression, represent potential biomarkers that could be evaluated in ongoing clinical trials of CFI-402257 or other TTKis.
A Slew Controlled LVDS Output Driver Circuit in 0.18 $\mu$m CMOS Technology (2009)

This article presents a power-efficient low-voltage differential signaling (LVDS) output driver circuit. The proposed approach helps to reduce the total input capacitance of the LVDS driver circuit and hence relaxes the tradeoffs in designing a low-power pre-driver stage. A slew control technique has also been introduced to reduce the impedance mismatch effect between the output driver circuit and the line. The pre-driver stage shows a total input capacitance of 50 fF and also controls the voltage swing and common-mode voltage at the input of the LVDS driver output stage. This makes the operation at low supply voltages using a conventional 0.18 mum CMOS technology feasible. The output driver circuit consumes 4.5 mA while driving an external 100 Omega resistor with an output voltage swing of V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OD</sub> = 400 mV, achieving a normalized power dissipation of 3.42 mW/Gbps. The area of the LVDS driver circuit is 0.067 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and the measured output jitter is sigma <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> = 4.5 ps. Measurements show that the proposed LVDS driver can be used at frequencies as high as 2.5 Gbps where the speed will be limited by the load RC time constant.
Shape-Selective Synthesis and Facet-Dependent Enhanced Electrocatalytic Activity and Durability of Monodisperse Sub-10 nm Pt−Pd Tetrahedrons and Cubes (2011)

Monodisperse single-crystalline sub-10 nm Pt-Pd nanotetrahedrons (NTs) and nanocubes (NCs) were synthesized with high shape selectivity via one-pot hydrothermal routes with small ions as efficient facet-selective agents. These alloy nanocrystals showed facet-dependent enhanced electrocatalytic activity and durability for methanol electrooxidations with commercial Pt/C catalyst as a reference. The (100)-facet-enclosed Pt-Pd NCs demonstrated a higher activity, whereas the (111)-facet-enclosed Pt-Pd NTs exhibited a better durability.
Retinol Intake and Bone Mineral Density in the Elderly: The Rancho Bernardo Study (2002)

Retinol is involved in bone remodeling, and excessive intake has been linked to bone demineralization, yet its role in osteoporosis has received little evaluation. We studied the associations of retinol intake with bone mineral density (BMD) and bone maintenance in an ambulatory community-dwelling cohort of 570 women and 388 men, aged 55-92 years at baseline. Regression analyses, adjusted for standard osteoporosis covariates, showed an inverse U-shaped association of retinol, assessed by food-frequency questionnaires in 1988-1992, with baseline BMD, BMD measured 4 years later, and BMD change. Supplemental retinol use, reported by 50% of women and 39% of men, was an effect modifier in women; the associations of log retinol with BMD and BMD change were negative for supplement users and positive for nonusers at the hip, femoral neck, and spine. At the femoral neck, for every unit increase in log retinol intake, supplement users had 0.02 g/cm2 (p = 0.02) lower BMD and 0.23% (p = 0.05) greater annual bone loss, and nonusers had 0.02 g/cm2 (p = 0.04) greater BMD and 0.22% (p = 0.19) greater bone retention. However, among supplement users, retinol from dietary and supplement sources had similar associations with BMD, suggesting total intake is more important than source. In both sexes, increasing retinol became negatively associated with skeletal health at intakes not far beyond the recommended daily allowance (RDA), intakes reached predominately by supplement users. This study suggests there is a delicate balance between ensuring that the elderly consume sufficient vitamin A and simultaneously cautioning against excessive retinol supplementation.
Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein. (1994)

The epidermal growth factor receptor, EGFR, has been implicated in cell transformation in both mammalian and avian species. The v-ErbB oncoprotein is an oncogenic form of the chicken EGFR. The tyrosine kinase activity of this oncoprotein is required for transformation, but no transformation-specific cellular substrates have been described to date. Recently activation of the ras signal transduction pathway by the EGFR has been shown to involve the Shc and Grb2 proteins. In this communication, we demonstrate that the Shc proteins are phosphorylated on tyrosine residues and are complexed with Grb2 and the chicken EGFR following ligand activation of this receptor. In fibroblasts and erythroid cells transformed by the avian erythroblastosis virus (AEV) strains H and ES4, the Shc proteins are found to be constitutively phosphorylated on tyrosine residues. The tyrosine-phosphorylated forms of the AEV strain H v-ErbB protein are found in a complex with Shc and Grb2, but the Shc proteins do not bind to the AEV strain ES4 v-ErbB protein. Mutant forms of the v-ErbB protein (in which several of the tyrosines that become autophosphorylated have been deleted by truncation) are unable to transform erythroid cells but can still transform fibroblasts. Analysis of cells transformed by one of these mutants revealed that the truncated v-ErbB protein could no longer bind to either Shc or Grb2, but this oncoprotein still gave rise to tyrosine-phosphorylated Shc proteins that complexed with Grb2 and led to activation of mitogen-activated protein (MAP) kinase. The results suggest that stable binding of Grb2 and Shc to the v-ErbB protein is not necessary to activate this signal transduction pathway and assuming that the mutant activate MAP kinase in erythroid cells in a manner similar to that of fibroblasts, that activation of this pathway is not sufficient to transform erythroid cells.
Sequential Hydrocarbon Functionalization:  Allylic C−H Oxidation/Vinylic C−H Arylation (2006)

A Pd(II)/sulfoxide-catalyzed sequential allylic C-H oxidation/vinylic C-H arylation of alpha-olefins to furnish E-arylated allylic esters in high regio- and E:Z selectivities (>20:1) is reported. The broad scope of this method with respect to the alpha-olefin, carboxylic acid, and aryl boronic acid enables the rapid assembly of densely functionalized fragments for complex molecule synthesis from cheap, abundant hydrocarbon starting materials. The Pd(II)/sulfoxide-catalyzed vinylic C-H arylation of electronically unbiased olefins with aryl boronic acids proceeds under oxidative, acidic conditions and mild temperatures (room temperature to 45 degrees C).
Food Justice in the Trump Age: Priorities for Urban Food Advocates (2017)

This essay outlines priorities for food advocates following the election of President Donald Trump. Specifically, this essay advocates for: 1. preservation of snap, 2. prevention of industry deregulation, and 3. sustainment of regional food systems. In its analysis, this essay examines each of the potential conservative-back counter proposals for these priorities.
Wave-front sensing from subdivision of the focal plane with a lenslet array (2005)

A wave-front sensing scheme based on placing a lenslet array at the focal plane of the telescope with each lenslet reimaging the aperture is analyzed. This wave-front sensing arrangement is the dual of the Shack-Hartmann sensor, with the wave front partitioned in the focal plane rather than in the aperture plane. This arrangement can be viewed as the generalization of the pyramid sensor and allows direct comparisons of this sensor with the Shack-Hartmann sensor. We show that, as with the Shack-Hartmann sensor, when subdividing in the focal plane, the quality of the wave-front estimate is a trade-off between the quality of the slope measurements over each region in the aperture and the resolution to which the slope measurements are obtained. Open-loop simulation results demonstrate that the performance of the lenslet array at the focal plane is equivalent to that of the Shack-Hartmann sensor when no modulation is applied to the lenslet array. However, when the array is modulated in a manner akin to that of the pyramid sensor, subdivision at the focal plane provides advantages when compared with the Shack-Hartmann sensor.
Classification of ß-Lactamase-Producing Bacteria (1982)

The resistance of bacteria to beta-lactam antibiotics, penicillins or cephalosporins, is usually associated with the production of beta-lactamase enzymes which are capable of inactivating these compounds. A number of recent surveys have reported a significant increase in the frequency of isolation of beta-lactamase-producing strains of bacteria from infections in general practice in the United Kingdom. A wide variety of bacterial beta-lactamases with different properties have been described and it is now recognised that most bacteria produce a chromosomally-mediated beta-lactamase which is characteristic of each species. In addition, Gram-negative bacteria may acquire beta-lactamases which are mediated by plasmids which are readily transferable by cell to cell contact. Schemes for the classification of bacterial beta-lactamases are outlined.
CS1 (CRACC, CD319) Induces Proliferation and Autocrine Cytokine Expression on Human B Lymphocytes (2007)

CS1 (CRACC, CD319), a member of the CD2 family of cell surface receptors, is implicated in the activation of NK cell-mediated cytotoxicity. Previous studies showed that CS1 is also expressed on activated B cells. However, the functional role of CS1 in human B-lymphocytes is not known. Two isoforms of CS1, CS1-L and CS1-S, are expressed in human NK cells that differentially regulate NK cell function. CS1-L contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain whereas CS1-S lacks immunoreceptor tyrosine-based switch motifs. In this study, we show that human B lymphocytes express only the CS1-L isoform, and its expression is up-regulated upon B cell activation with various stimulators. Moreover, anti-CS1 mAb strongly enhanced proliferation of both freshly isolated as well as activated B cells. The enhanced proliferation effects of CS1 were most prominent on B cells activated by anti-CD40 mAbs and/or hrIL-4. The effects of CS1 on B cell proliferation were shown on both naive and memory B cells. Human cytokine microarray and quantitative real-time PCR results indicated that CS1 activation enhanced mRNA transcripts of flt3 ligand, lymphotoxin A, TNF, and IL-14. Neutralizing Abs against lymphotoxin A, TNF-alpha, and/or flt3 ligand abolished the ability of CS1 on the B cell proliferation. These results suggest that activation of B lymphocytes, through surface CS1, may be mediated through secretion of autocrine cytokines and CS1 may play a role in the regulation of B lymphocyte proliferation during immune responses.
Demonstrations of Multi-constellation Advanced RAIM for Vertical Guidance Using GPS and GLONASS Signals (2011)

In the near future, many more navigation satellites with dual frequency L1 and L5 will be deployed. The increased number of satellites and the possibility of mitigating the ionospheric delay using dual frequency have opened the door to the possible use of RAIM for vertical guidance. For this purpose, several Advanced RAIM (ARAIM) algorithms have been proposed. Extensive simulation studies have established that with two constellations it might be possible to achieve global coverage of LPV 200, which requires a 35 meter Vertical Alert Limit. Previous work [1], [2], [3] with large amounts of receiver data has demonstrated the ability of ARAIM to compute a Vertical Protection Level (VPL) that bounds the Vertical Position Error (VPE). However, in that effort, only GPS measurements were tested for the validation of ARAIM. Therefore, multi-constellation evaluation of ARAIM performance will be necessary. In addition to GPS, the only full constellation, or nearing Final Operation Capability, is GLONASS. In this paper, we will validate ARAIM further using ten days of GPS and GLONASS measurements collected by a GLONASS capable GNSS receiver. From the stored data, we will compute all the figures of merit that are necessary for LPV-200, in particular the Vertical Protection Level (VPL) and the accuracy. We will test the ability of the algorithm to predict accuracy and its ability to compute a VPL that bounds the Vertical Protection Error. This will represent one of the first demonstrations of multi-constellation ARAIM with real data.