gebhart/patrepeval huggingface dataset:
FRIEDEL AND CRAFTS' REACTION. THE CARBOMETHOXY-BENZOYL CHLORIDES WITH AROMATIC HYDROCARBONS AND ALUMINUM CHLORIDE. (1921)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFRIEDEL AND CRAFTS' REACTION. THE CARBOMETHOXY-BENZOYL CHLORIDES WITH AROMATIC HYDROCARBONS AND ALUMINUM CHLORIDE.Maurice E. SmithCite this: J. Am. Chem. Soc. 1921, 43, 8, 1920–1924Publication Date (Print):August 1, 1921Publication History Published online1 May 2002Published inissue 1 August 1921https://pubs.acs.org/doi/10.1021/ja01441a020https://doi.org/10.1021/ja01441a020research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phototheranostic Porphyrin Nanoparticles Enable Visualization and Targeted Treatment of Head and Neck Cancer in Clinically Relevant Models (2015)

Head and neck cancer is the fifth most common type of cancer worldwide and remains challenging for effective treatment due to the proximity to critical anatomical structures in the head and neck region, which increases the probability of toxicity from surgery and radiotherapy, and therefore emphasizes the importance of maximizing the targeted ablation. We have assessed the effectiveness of porphysome nanoparticles to enhance fluorescence and photoacoustic imaging of head and neck tumors in rabbit and hamster models. In addition, we evaluated the effectiveness of this agent for localized photothermal ablative therapy of head and neck tumors. We have demonstrated that porphysomes not only enabled fluorescence and photoacoustic imaging of buccal and tongue carcinomas, but also allowed for complete targeted ablation of these tumors. The supremacy of porphysome-enabled photothermal therapy over surgery to completely eradicate primary tumors and metastatic regional lymph node while sparing the adjacent critical structures' function has been demonstrated for the first time. This study represents a novel breakthrough that has the potential to revolutionize our approach to tumor diagnosis and treatment in head and neck cancer and beyond.
Semaphorin 7A plays a critical role in TGF-β1–induced pulmonary fibrosis (2007)

Semaphorin (SEMA) 7A regulates neuronal and immune function. In these studies, we tested the hypothesis that SEMA 7A is also a critical regulator of tissue remodeling. These studies demonstrate that SEMA 7A and its receptors, plexin C1 and beta1 integrins, are stimulated by transforming growth factor (TGF)-beta(1) in the murine lung. They also demonstrate that SEMA 7A plays a critical role in TGF-beta(1)-induced fibrosis, myofibroblast hyperplasia, alveolar remodeling, and apoptosis. TGF-beta(1) stimulated SEMA 7A via a largely Smad 3-independent mechanism and stimulated SEMA 7A receptors, matrix proteins, CCN proteins, fibroblast growth factor 2, interleukin 13 receptor components, proteases, antiprotease, and apoptosis regulators via Smad 2/3-independent and SEMA 7A-dependent mechanisms. SEMA 7A also played an important role in the pathogenesis of bleomycin-induced pulmonary fibrosis. TGF-beta(1) and bleomycin also activated phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB)/AKT via SEMA 7A-dependent mechanisms, and PKB/AKT inhibition diminished TGF-beta(1)-induced fibrosis. These observations demonstrate that SEMA 7A and its receptors are induced by TGF-beta(1) and that SEMA 7A plays a central role in a PI3K/PKB/AKT-dependent pathway that contributes to TGF-beta(1)-induced fibrosis and remodeling. They also demonstrate that the effects of SEMA 7A are not specific for transgenic TGF-beta(1), highlighting the importance of these findings for other fibrotic stimuli.
Using Web search engines to find and refind information (2005)

To inform the design of next-generation Web search tools, researchers must better understand how users find, manage, and refind online information. Synthesizing results from one of their studies with related work, the authors propose a search engine use model based on prior task frequency and familiarity.
Investigation of the application of RANS turbulence models to the calculation of nonisothermal low-Prandtl-number flows (2015)

The RANS turbulence models intended for modeling turbulent low-Prandtl-number flows are described. With reference to the example of sodium liquid-metal heat-transportmedium the specialized models presented are compared with the standard RANS models having the highest rating. The adequacy of modeling heat transfer using the specialized models is studied with reference to the example of a heated backward-facing step for which both thermal and dynamic parameters are evaluated.
A robust classifier of high predictive value to identify good prognosis patients in ER-negative breast cancer (2008)

This seven-gene classifier could be used in a polymerase chain reaction-based clinical assay to identify ER- patients with a good prognosis, who may therefore benefit from less aggressive treatment regimens.
Neutrophil-Platelet Adhesion: Relative Roles of Platelet P-Selectin and Neutrophil β2 (CD18) Integrins (1998)

Neutrophils and platelets interact both physically and metabolically during inflammation and thrombosis, but the mechanisms responsible for their adhesion remain incompletely understood. Neutrophil-platelet adhesion was measured after specific stimulation of neutrophils, platelets, or both and quantified by flow cytometry. Specific stimulation of either the neutrophil or the platelet led to a marked increase in the percentage of neutrophils that bound platelets, although platelet stimulation led to a large increase and neutrophil stimulation to only a small increase in the number of platelets per neutrophil. Stimulation of both cells further increased the number of neutrophil-platelet adhesive events and led to large numbers of platelets binding to each neutrophil. Confirming previous observations, blocking antibodies to platelet P-selectin (CD62P) partially inhibited adhesion. However, blockade of the neutrophil beta2 integrin CD11b/CD18 also inhibited the percentage of neutrophils that bound platelets. Combining P-selectin and CD11b/18 blockade further inhibited the stimulated increase in the percentage of neutrophils binding platelets and the increased number of platelets per neutrophil. Both cell adhesion molecules were active even when only a single cell type was primarily activated, supporting physiologically important transcellular activation. These data suggest that: (1) neutrophil-platelet adhesion can be initiated by specific activation of either the neutrophil or the platelet and that specific activation of either cell type leads to distinct patterns of adhesion, and (2) neutrophil-platelet adhesion uses both platelet P-selectin and the neutrophil beta2 integrin CD11b/CD18 when the cells are primarily or secondarily activated.
A new solution expressed in terms of UTD coefficients for the multiple diffraction of spherical waves by a series of buildings (2007)

A new formulation expressed in terms of Uniform Theory of Diffraction (UTD) coefficients for the prediction of the multiple diffraction caused by a series of buildings modeled as wedges, considering spherical‐wave incidence, is presented. The solution, which has a certain heuristic nature, is validated with numerical results from technical literature and the particular cases of diffraction by buildings modeled as absorbing knife edges, as well as the one in which the mentioned buildings are replaced by flat‐roofed parallel rows of blocks (building rows in cross sections considered to be rectangular in shape) are also analyzed. The computing time is reduced over existing formulations, especially when the number of buildings is large, and the results can be applied in the development of theoretical models, in order to predict a more realistic path loss in urban environments when multiple‐building diffraction has to be considered.
A <i>BCR–JAK2</i> fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia (2005)

Chronic myeloid leukemia (CML) is characterized by the presence of a t(9;22)(q34;q11.2), which leads to the well-known BCR-ABL1 fusion protein. We describe a patient who was diagnosed clinically with a typical CML but on cytogenetic analysis was found to have a t(9;22)(p24;q11.2). Chromosomal fluorescence in situ hybridization showed that the BCR gene locus spanned the breakpoint at band 22q11.2 but that the ABL1 gene was not rearranged. By means of a candidate gene approach, the JAK2 gene, at 9p24, was identified as the fusion partner of BCR in this case. The BCR-JAK2 fusion protein contains the coiled-coil dimerization domain of BCR and the protein tyrosine kinase domain (JH1) of JAK2. The patient's disease did not respond to Imatinib, and this unresponsiveness was most likely a result of the BCR-JAK2 fusion protein.
Hindmilk Improves Weight Gain in Low-Birth-Weight Infants Fed Human Milk (1994)

*Sections of Neonatology, Houston, Texas, U.S.A. †Pediatric Gastroenterology, Houston, Texas, U.S.A. †Department of Pediatrics, Children's Nutrition Research Center, Houston, Texas, U.S.A. §Baylor College of Medicine, Houston, Texas, U.S.A. ¶Texas Children's Hospital, Houston, Texas, U.S.A.
A Framework for Decentralising Multi-Cell Cooperative Processing on the Downlink (2008)

Multi-cell cooperative processing (MCP) is well acknowledged for significantly improving spectral efficiency and fairness amongst users. Nevertheless MCP comes together with some shortcomings which have also been recognised. Cooperating Base Stations (BSs) need to be inter-connected via a Control Unit (CU) which gathers channel state information (CSI). CU is the entity responsible for performing MS scheduling and defining the transmission parameters. Under a practically feasible linear preceding framework, CU performs user scheduling and designs the beamforming matrix for the chosen users. Therefore MCP implementation adds a very significant infrastructure cost as it requires a CU and low latency links connecting cooperating BSs with it. Furthermore this entails an important protocol complexity in order for all this signaling to be coordinated. In this paper a new framework is proposed that allows MCP on the downlink without the need of costly modifications on the infrastructure comparing to the existing cellular networks. The needed operations are performed in a distributed fashion by the cooperating BSs and this is shown to be a good alternative facilitating MCP implementation.
BERTScore: Evaluating Text Generation with BERT (2020)

We propose BERTScore, an automatic evaluation metric for text generation. Analogously to common metrics, BERTScore computes a similarity score for each token in the candidate sentence with each token in the reference sentence. However, instead of exact matches, we compute token similarity using contextual embeddings. We evaluate using the outputs of 363 machine translation and image captioning systems. BERTScore correlates better with human judgments and provides stronger model selection performance than existing metrics. Finally, we use an adversarial paraphrase detection task and show that BERTScore is more robust to challenging examples compared to existing metrics.
A Framework for Detecting MAC and IP Spoofing Attacks with Network Characteristics (2016)

This paper presents a spoofing attack detection framework based on physical network characteristics (e.g., received signal strength indicator round trip time and link quality indicator) that cannot easily be mimicked by artificial means. Unlike most previous studies that are sensitive to changes in network conditions, we propose a spoofing attack detection method, which is highly robust to the changes of network conditions over time. The proposed framework can monitor devices' physical network characteristics in real time and check if any significant changes have been made in the monitored measurements to effectively detect device spoofing attacks. To demonstrate the feasibility of the proposed framework, we analyzed how the RSSI values of packets were changed with varying physical distances in a real ZigBee (IEEE 802.15.4) network environment.
Long-term results of artificial chordae implantation in patients with mitral valve prolapse. (1997)

MVR with artificial chordae provided satisfactory valve function for up to nine years. Gore-Tex chordae are less prone to deterioration than pericardial chordae. Follow up observations support the use e-PTFE chordae to correct diffuse leaflet prolapse.
Management of cardiovascular disease (1999)

Advances in technology, pharmacotherapy and preventive strategies continue apace
Reversible Tuning Luminescent Color and Emission Intensity: A Dipeptide‐Based Light‐Emitting Material (2012)

A smart luminescent material whose emission color and emission intensity can be separately modulated by external force is demonstrated. The rational manipulation of rich noncovalent interactions and fluorophore packing style promotes an in-depth understanding between supramolecular structure and photophysical property and offers an effective strategy to modulate the light-emitting property in a predicative way.
Use of Human Immunodeficiency Virus-1 Protease Inhibitors Is Associated With Atherogenic Lipoprotein Changes and Endothelial Dysfunction (2001)

Use of HIV PIs is associated with atherogenic lipoprotein changes and endothelial dysfunction. Because these metabolic and vascular changes predispose to atherosclerosis, monitoring and treatment of dyslipidemia in patients taking these medications is warranted.
Chicken MAR binding protein p120 is identical to human heterogeneous nuclear ribonucleoprotein (hnRNP) U (1994)

We have previously identified two proteins from chicken oviduct nuclei that specifically bind to matrix/scaffold attachment regions (MARs/SARs). Here one of these proteins, named p120 due to its apparent molecular weight, is purified to near homogeneity and shown to be identical to a previously described component of heterogeneous nuclear ribonucleoprotein particles, hnRNP U, on the basis of amino acid sequence analysis of tryptic peptides. p120 binds to multiple MAR fragments provided they have a minimal length of approximately 700 bp. Binding of MAR fragments is specifically competed by homoribopolymers poly(G) and poly(I), which form four-stranded structures. Our results suggest that p120/hnRNP U may serve a dual function, first as a component of hnRNP particles, and second as an element in the higher-order organization of chromatin.
Hypoxanthine measurement in assessing freshness of chilled channel catfish (Ictalurus punctatus) (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHypoxanthine measurement in assessing freshness of chilled channel catfish (Ictalurus punctatus)Larry R. BeuchatCite this: J. Agric. Food Chem. 1973, 21, 3, 453–455Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://pubs.acs.org/doi/10.1021/jf60187a020https://doi.org/10.1021/jf60187a020research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Field sampling strategies for studies of alfalfa forage quality (2001)

Information is scarce on sampling techniques for field studies of alfalfa forage quality. Standard formulas are available for estimating the number of samples needed for reducing error in a study, but little is known about the impact of plot sampling on forage quality. Our objectives were to compare the strategy of manual harvesting from small areas within plots with that of grab sampling mechanically harvested forage, and to determine whether the within-plot location of sampling affected forage quality in any systematic way. Alfalfa forage was sampled from swaths of mechanically clipped forage (grab samples) and from hand-clipped areas within field plots (area samples). Systematic sample location within a plot had no discernable effect on forage quality. Calculations of predicted standard errors and required sample numbers indicated that one area or one grab sample per plot with three replicates would provide an acceptable standard error for comparison of alfalfa entries for protein and fiber concentration. Within-plot variability was greater at late-summer harvests than earlier harvests, but at all harvests one sample per plot with three replicates gave adequate precision for forage quality comparisons. Higher forage quality from grab samples than from area samples at spring harvests suggested the need for caution when comparing forage quality studies done with different harvest methods; however, there were few entry × sampling strategy interactions, which suggests that relative performance of entries would be similar regardless of the method of sampling. Key words: Alfalfa, forage quality, Medicago sativa L.; field sampling, bootstrap
Human IgG Monoclonal Anti-αIIbβ3-Binding Fragments Derived from Immunized Donors Using Phage Display (2002)

Previous studies of the immune response in polytransfused Glanzmann thrombasthenia (GT) patients and in autoimmune thrombocytopenic purpura (AITP) have relied on serum analysis and have shown the frequent development of Abs directed against the alpha(IIb)beta(3) integrin. However, little is known about the molecular diversity of the humoral immune response to alpha(IIb)beta(3) due to the paucity of mAbs issuing from these pathologies. We have isolated human IgG anti-alpha(IIb)beta(3) binding fragments using combinatorial libraries of single-chain IgG created from the B cells of a GT and an AITP patient, both with serum Abs. Ab screening was performed using activated platelets or activated alpha(IIb)beta(3)-expressing Chinese hamster ovary cells. Sequencing of selected phage Abs showed that a broad selection of genes from virtually all V gene families had been used, indicating the diversity of the immune response. About one-half of the V(H) and V(L) segments of our IgG anti-alpha(IIb)beta(3) fragments displayed extensive hypermutations in the complementarity-determining region, supporting the idea that an Ag-driven immune response was occurring in both patients. The H chain complementarity-determining region 3 analysis of phage Abs revealed motifs other than the well-known RGD and KQAGDV integrin-binding sequences. To our knowledge, our study is the first to illustrate multiple human IgG anti-alpha(IIb)beta(3) reactivities and structural variations linked to the anti-platelet human immune response. Human alpha(IIb)beta(3) Abs preferentially directed against the activated form of the integrin were further characterized because platelet alpha(IIb)beta(3) inhibitors are potential therapeutic reagents for treating acute coronary syndromes. Currently available alpha(IIb)beta(3) antagonists do not specifically recognize the activated form of the integrin.
Copper(<scp>I</scp>)‐Directed Formation of a Cyclic Pseudorotaxane Tetramer and Its Trimeric Homologue (2005)

A matter of concentration: Cyclic pseudorotaxanes are formed by the addition of copper(I) ions to a ligand consisting of a ring containing a chelating unit and, appended to the ring, a rigid fragment containing another chelating unit. The tetramer is formed as the major product in concentrated solution, and the analogous trimer prevails in more dilute solution; both species are connected through a concentration-dependent slow equilibrium. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503163_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Events-Based Exception Handling in Supply Chain Management using Web Services (2006)

In this paper, a generic model MNC-SMS (Monitor, Notify, Control, Simulate, Measure, Subscription) is proposed in handling events-based exceptions that occur in complex supply chain management business processes. This model is proposed to resolve any "unexpected events" to enhance business process automation and minimize any human intervention. Events-based exceptions represent businesslevel exceptions in this paper. A real case study scenario of order fulfillment in a typical supply chain has been prototyped using Web services. A prototype is developed as a proof of concept using Microsoft BizTalk Server 2004.
Monolithic integration of an InP/InGaAs four-channel transimpedance optical receiver array (1990)

Fully functional four-channel transimpedance receiver array OEICs have been fabricated on 2″ diameter InP substrates. Each receiver channel has a bandwidth of 200 MHz and an average input equivalent noise current of around 6pA/√(Hz). The array chip is 3.7 mm × 3.2 mm in size and contains 88 components. This is believed to represent the highest level of optoelectronic integration yet reported on InP.
Weekly intravenous nanoparticle albumin-bound paclitaxel for elderly patients with stage IV non-small-cell lung cancer: a series of 20 cases (2012)

The purpose of this study was to evaluate the efficacy and safety of nanoparticle albumin-bound paclitaxel as a rescue regimen in the treatment of patients with advanced non-small-cell lung cancer. We retrospectively reviewed the medical records of 20 patients with stage IV non-small-cell lung cancer. The patients had progressive disease after standard antitumor therapy and subsequently received intravenous albumin-bound paclitaxel at the dose of 100 mg/m(2) in weekly schedule. Cumulative findings showed that the overall response rate was 30.0%, the disease control rate amounted to 40%, and the 1 year survival rate was 30%. In addition, the median time to progression and the median survival time reached 5 and 10 months, respectively. Meanwhile, no severe hypersensitivity reactions and grade 4 adverse effects were reported. In summary, weekly-administered albumin-bound paclitaxel seems to be an effective and safe regimen for elderly patients with stage IV non-small-cell lung cancer who were refractory to conventional therapy.