gebhart/patrepeval huggingface dataset:
Lithographically induced self-construction of polymer microstructures for resistless patterning (1999)

We have discovered and developed a method that can directly pattern polymer microstructures of arbitrary shapes without using a resist, exposure, chemical development, and etching. A mask with protruded patterns is placed a distance above an initially flat polymer film cast on a substrate. During a heating cycle that raises the temperature above the polymer’s glass transition temperature and then cooled back to the room temperature, we found that the polymer was attracted to the mask protrusions on their own, forming the mesas that have a lateral dimension identical to that of the mask protrusions, a height equal to the distance between the mask and the substrate, and a relatively steep sidewall. The method, termed lithographically induced self-construction, is important to the fabrication of polymer electronic and optoelectronic devices.
Chromosomal abnormalities in HPV-16-immortalized oral epithelialcells (1996)

Human papilloma virus (HPV) type 16 has an established association with anogenital carcinoma, and to some extent with human oral squamous cell carcinoma. We hypothesize that HPV type 16 is capable of inducing chromosomal and cell cycle changes in cultured oral epithelial cells. Normal human oral epithelia] cells were immortalized with recombinant retrovirus containing the E6/E7 open reading frames of HPV type 16. These cells have been in culture for more than 350 passages and over 4 years. Flow cytometry demonstrated an average of 42% nuclear aneuploidy in HPV 16-immortalized cells; 16% in normal controls (probably tetrasomy). Cytogenetic analysis demonstrated significant progression of chromosomal abnormalities. Cells at early passage (p10) showed trisomy 20, with no other major changes. At passage 18, trisomy 1q and monosomy 13 were seen in addition to trisomy 20. At passage 61 there were two distinct cell populations ('a' and 'b'), with multiple chromosomal changes including trisomy 5q,14,20 in one line and 7p,9q,llq in the other. Both populations had monosomy 3p, with monosomy 8p in one population and monosomy 13 in the other. At passage 136, the cells were essentially identical to population 'b' of passage 61. At this passage, mutation of the p53 gene was detected at codon 273 of exon 8, with G to T conversion (Arg to Leu). This was absent in the normal cells from which this line was developed. Passage 262 contained the two major cell populations, each with a sub-group with additional chromosomal changes such as 10p monosomy. Cells from passages 217 and 305 were injected into nude mice a year apart. Both failed to produce tumors, as did normal cells. In conclusion, we present an HPV type 16-immortalized oral epithelial cell line (IHGK) with extensive and progressive chromosomal abnormalities, invasive growth in culture and yet no tumor formation in nude mice. We suggest that the question as to whether HPV alone can induce transformation is still open.
Perfil de aminoácidos de la proteína unicelular de kluyveromyces marxianus var. Marxianus. (2008)

Resumen es: Se estudio el perfil de aminoacidos de la proteina unicelular (PUC) de la levadura Kluyveromyces marxianus var. marxianus (ATCC 8554) utilizando lactosue...
The Difficulties in Emotion Regulation Scale (DERS) (2012)

Successful emotion regulation is a key aspect of efficient social functioning and personal well-being. Difficulties in emotion regulation lead to relationship impairments and are presumed to be involved in the onset and maintenance of some psychopathological disorders as well as inappropriate behaviors. Gratz and Roemer (2004 ) developed the Difficulties in Emotion Regulation Scale (DERS), a comprehensive instrument measuring emotion regulation problems that encompasses several dimensions on which difficulties can occur. The aim of the present work was to develop a French translation of this scale and to provide an initial validation of this instrument. The French version was created using translation and backtranslation procedures and was tested on 455 healthy students. Congruence between the original and the translated scales was .98 (Tucker’s phi) and internal consistency of the translation reached .92 (Cronbach’s α). Moreover, test-retest scores were highly correlated. Altogether, the initial validation of the French version of the DERS (DERS-F) offers satisfactory results and permits the use of this instrument to map difficulties in emotion regulation in both clinical and research contexts.
.ALPHA.-Amylase of Rhizopus niveus: Its isolation and some enzymic properties. (1990)

The α-amylase usually contained in commercial Rhizopus glucoamylase preparations was isolated and purified to an electrophoretically pure state. The optimum pH of the enzyme was around 5.0-5.2 The enzyme was stable over a pH range from 3.0 to 8.0 where the stability was not affected by the presence of EDTA. On the other hand, the enzyme was sensitive at temperatures higher than 50°C, and highly sensitive to mercuric ions. The action pattern on and specificity for starch of Rhiz, α-amylase considerably differed from those of Taka amylase. In the specificity, Rhiz. α-amylase seemed to be rather similar to bacterial α-amylase of saccharifying type. On the other hand, Rhiz. α-amylase showed negligible activity in degrading raw corn starch, but accelerated the hydrolysis of starch by Rhiz. glucoamylase. This acceleration mechanism of Rhiz. α-amylase remains unsolved. However, the a-amylase was observed to make wider the holes being bored by glucoamylase on starch granules and the implication of the results was discussed.
The Quest for a Religious America (1967)

Journal Article The Quest for a Religious America Get access A Christian View of Sex and Marriage. By ANDREW R. EICKHOFF. New York: The Free Press, 1966. x+270 pages. $6.95. PAUL E. JOHNSON PAUL E. JOHNSON Indianapolis Pastoral Counseling Center Search for other works by this author on: Oxford Academic Google Scholar Journal of the American Academy of Religion, Volume XXXV, Issue 3, September 1967, Page 293, https://doi.org/10.1093/jaarel/XXXV.3.293 Published: 01 September 1967
A High-Speed Line Scanner for Use in an Electronic Switching System (1958)

A high-speed multiposition electronic switch has been developed to act as a time-division information-gathering device for the experimental electronic switching system. This switch, called the scanner, provides central control with random access to all lines and trunks terminating in the central office and permits sampling their stales for the reception of supervisory and dial pulse signals.
A Short-Step Synthesis of Orally Active Carbapenem Antibiotic CS-834. (2000)

An orally bioavailable carbapenem CS-834, which is a pivaloyloxymethyl (POM) ester-type prodrug and has (R)-5-oxopyrrolidin-3-ylthio moiety at the C-2 position of the 1 beta-methylcarbapenem skeleton, is currently under clinical trial. We accomplished a short-step synthesis of CS-834 by using phosphorus ylide from the intramolecular Wittig-type reaction in the key step for cyclization to the bicyclic carbapenem system. The POM ester group was found to be suitable for the cyclization conditions.
The PEN&PAD data entry system: from prototype to practical system. (1996)

This paper describes some of the issues addressed in the transition of the PEN&PAD from prototype clinical workstation to practical data entry system for use by general practitioners in the UK. Background and motivation of the PEN&PAD and GALEN projects are presented before the operation of the PEN&PAD user interface is described. A number of issues which have arisen in the development of the PEN&PAD Data Entry System are discussed.
High and Low Perceived Self‐Control of Epileptic Seizures (2001)

Many people with intractable seizures do not accept their epilepsy as a condition over which they have no control. Perceived self-control of seizures, however, involves a complex interaction between epilepsy and psychological factors, with health locus of control an apparently important discriminator between High and Low Controllers.
A Japanese Encephalitis Vaccine From India Induces Durable and Cross-protective Immunity Against Temporally and Spatially Wide-ranging Global Field Strains (2015)

CTRI/2011/07/001855.
Short-channel effect in fully depleted SOI MOSFETs (1989)

The short-channel effect in fully depleted silicon-on-insulator MOSFETs has been studied by a two-dimensional analytical model and by computer simulation. The calculated values agree well with the simulation results. It is found that the vertical field through the depleted film strongly influences the lateral field across the source and drain regions. The short-channel effect can be significantly reduced by decreasing the silicon film thickness.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Power efficient femtocell distribution strategies (2011)

Reducing our power consumption is an urgent issue which has important economical and ecological benefits. By using femtocell technology the mobile network can become far more energy efficient than it is today. In this paper, we describe what femtocell technology is and introduce outdoor femtocell distribution strategies that can save the network power. We also compare the usage of typical short-range base stations in place of femtocells and show that femtocells are more efficient. The results of the introduced strategies show that significant power savings of up to 92% can be achieved on a per-macrocell basis if implemented.
Analysis of Forages by Infrared Reflectance (1979)

Infrared reflectance is a rapid accurate procedure for measuring nutrients in grains and forages. Factors that affect prediction of forage quality include plant species, method of preservation, and constituents in the forage other than those being measured. Selection of wavelengths for prediction is the key. Statistical procedures are being studied to improve selection of wavelength and to lower prediction errors. Commercial instruments recently introduced have greater data processing capabilities and greater wavelength (filter) selection than earlier models, but more research is needed to determine the appropriate wavelengths for each type of forage and feedstuff. An alternative to the filter instrument would be a small monochromator-based instrument similar to the prototype we have developed. This instrument can collect, process, and select a set of wavelengths to use for prediction for each different wpe of forage or feedstuff. New applications of infrared reflectance include identification of the sample from the spectra, prediction of percent legume +10% in grass-legume mixtures, heat damaged protein (acid detergent fiber insoluble nitrogen -+.01%), phosphorous -+.04%, calcium +.14%, calcium to phosphorous ratio +.68%, po-
Relationship between Sterol/Steroid Structure and Participation in Ordered Lipid Domains (Lipid Rafts):  Implications for Lipid Raft Structure and Function (2004)

The formation and stability of ordered lipid domains (rafts) in model membrane vesicles were studied using a series of sterols and steroids structurally similar to cholesterol. In one assay, insolubility in Triton X-100 was assessed in bilayers composed of sterol/steroid mixed with dipalmitoylphosphatidylcholine (DPPC), dioleoylphosphatidylcholine, or a 1:1 mixture of these phospholipids. In a second assay fluorescence quenching was used to determine the degree of ordered domain formation in bilayers containing sterol/steroid and a 1:1 mixture of DPPC and a quencher-carrying phosphatidylcholine. Both methods showed that several single modifications of the cholesterol structure weaken, but do not fully abolish, the ability of sterols and steroids to promote ordered domain formation when mixed with DPPC. Some of these modifications included a shift of the double bond from the 5-6 carbons (cholesterol) to 4-5 carbons (allocholesterol), derivatization of the 3-OH (cholesterol methyl ether, cholesteryl formate), and alteration of the 3-hydroxy to a keto group (cholestanone). An oxysterol involved in atherosclerosis, 7-ketocholesterol, formed domains with DPPC that were as thermally stable as those with cholesterol although not as tightly packed as judged by fluorescence anisotropy. It was also found that 7-ketocholesterol has fluorescence quenching properties making it a useful spectroscopic probe. Lathosterol, which has a 7-8 carbon double bond in place of the 5-6 double bond of cholesterol, formed rafts with DPPC that were at least as detergent-resistant as, and even more thermally stable than, rafts containing cholesterol. Because lathosterol is an intermediate in cholesterol biosynthesis, we conclude it is unlikely that sterol biosynthesis continues past lathosterol in order to create a raft-favoring lipid.
Synthesis and Structure of Three Unusual Homoleptic Aryloxides of Nickel and Palladium (2002)

Homoleptic group 10 aryloxides consisting of discrete molecules have been isolated from the reaction of the sodium salts of bulky phenols with NiBr2(dme) or PdCl2(MeCN)2. The nickel 2,6-diisopropylphenolate is a trimer, displaying σ-coordinated aryloxide ligands, while the Ni and Pd derivatives of 2,6-di-tert-butylphenol are monomers that adopt an unprecedented π-allylic, sandwich-like structure.
Lagrangian Relaxation Algorithm for a Single Machine Scheduling with Release Dates (2008)

The paper considers a single machine scheduling problem with release dates to minimize the total completion times of jobs. The problem belongs to the class of NP-hard. We present a mixed-integer linear programming formulation based on slot idea. The original problem becomes an allocation problem where the main model decisions define the assignment of the time slot at which every job to be processed on a single machine. Lagrangian relaxation (LR) is proposed to solve the problem. Due to slot-based modeling, the application of LR in our problem can be extended to solve the problem with continuous-time variables, which is always confined to be used to the problem with discrete-time variables. Lagrangian-based heuristic consists of two phases: construction procedure and improvement procedure, which is based on pair-wise interchanges and kick strategy. Computational results show the Lagrangian-based heuristic is effective. The quality of the upper bounds obtained from the Lagrangian-based heuristic is advisable for the small size problem since the best feasible solutions generated are closed to the optimal values obtained by CPLEX.
The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues. (1975)

In crude extracts of adipose tissue the protein kinase dissociates slowly at 30 degrees into regulatory and catalytic subunits in the presence of 700 mug per ml of histone or 0.5 M NaCl. If the kinase is first dissociated by adding 10 muM adenosine 3':5'-monophosphate (cAMP), reassociation occurs instantaneously after removal of the cAMP by Sephadex G-25 chromatography. In contrast, in crude xtracts of heart, the protein kinase dissociates rapidly in the presence of 700 mug per ml of histone or 0.5 M NaCl and reassociates slowly after removal of cAMP. These differences are accounted for by the existence of two types of protein kinases in these tissues, referred to as types I and II. DEAE-cellulose chromatography of extracts of adipose tissue produces only one peak of cAMP-dependent protein kinase activity (type II) which elutes between 0.15 and 0.25 M NaCl. Similar chromatography of heart extracts resolves enzyme activity into two peaks; a type I enzyme which elutes between 0.05 and 0.1 M and predominates (greater than 75% of total activity), and a type II enzyme which elutes between 0.15 and 0.25 M NaCl. The dissociation properties of the types I and II enzymes from heart and adipose tissue are retained after partial purification by DEAE-cellulose and Sepharose 6B chromatography. Rechromatography of the separated peaks of the cardiac enzymes does not change the elution pattern. Sucrose density gradient centrifugation and gel filtration studies indicate that the molecular weights of these enzymes are very similar. The type II enzyme isolated by DEAE-cellulose chromatography of heart extracts resembles the adipose tissue enzyme, i.e. it undergoes slow dissociation at 30 degrees in the presence of histone or 0.5 M NaCl. The adipose tissue kinase and the heart type II kinase are not identical, however, since they do not elute at exactly the same point on DEAE-cellulose columns. A survey of several tissues indicates the presence of type I and II protein kinases similar to the enzymes in adipose tissue and heart as determined by DEAE-cellulose chromatography of crude extracts and by dissociation of the enzymes with histone. The presence of MgATP prevents dissociation of type I enzyme from heart by 0.5 M NaCl or histone. The profile of the enzyme on DEAE-cellulose, however, is not changed...
Method for the Generation of Very Fast Light Pulses (1957)

A method is described in which a visible or infrared light beam is repeatedly reflected between a rotating and stationary mirror system. The resulting sweep speed is proportional to the number of such reflections. Light pulses of 4×10−8 sec duration were measured. A considerable increase in the sweep speed appears feasible. Various applications of the system are mentioned.
Expression of urokinase‐type plasminogen activator, its receptor and type‐1 plasminogen activator inhibitor is differently regulated by inhibitors of protein synthesis in human cancer cell lines (1996)

Expression of the various components of the plasminogen activation system is under tight regulation by hormones, cytokines, and growth factors under physiologic conditions. Like early-response genes, these components are modulated by inhibitors of protein synthesis in some cell lines. To clarify the specific expression and regulation of mRNAs for urokinase (uPA), its receptor (uPAR), and type-1 plasminogen activator inhibitor (PAI-1), I analyzed RNA from four human cancer cell lines by RNA blotting after treatment with cycloheximide, anisomycin, emetine or puromycin. These inhibitors, all of which induced translational arrest, induced a very diverse response in the various transcripts, suggesting that the inhibitors mediate their effects through different molecular mechanisms. Dose-response analysis showed that, in A549 cells, anisomycin strongly induced uPAR and PAI-1 mRNA at concentrations that did not cause complete inhibition of protein synthesis, whereas cycloheximide induced these transcripts in a dose-dependent manner only at concentrations sufficient to inhibit total protein synthesis by >90%. Puromycin induced the 3.4-kb transcript of PAI-1 mRNA in A549 and RD cells, whereas it decreased the expression of both the 3.4-kb and 2.4-kb PAI-1 transcripts in HT-1080 cells. Different time patterns of induction for uPA, uPAR and PAI-1 mRNA suggest that even in the same cell type, inhibitors of protein synthesis mediate their effects on various genes through different mechanisms. Thus, induction of uPA, uPAR, and PAI-1 transcripts by inhibitors of protein synthesis was dependent on the gene, the cell line, and the type of inhibitor, and inhibition of protein synthesis per se was not sufficient for induction of these transcripts.
Synthesis, Characterization, Electronic Structure, and Photocatalytic Behavior of CuGaO<sub>2</sub> and CuGa<sub>1–<i>x</i></sub>Fe<sub><i>x</i></sub>O<sub>2</sub> (<i>x</i> = 0.05, 0.10, 0.15, 0.20) Delafossites (2011)

The photochemical reduction of CO2 to chemicals, such as CO and CH4, is a promising carbon management approach that can generate revenue from chemical sales to help offset the costs associated with the use of carbon-management technologies. Delafossite materials of the general stoichiometry ABO2 are a new class of photocatalysts being considered for this application. Symmetry breaking in these materials, by chemical substitution, modifies the band structure of the solid, which enhances optical transitions at the fundamental gap and can therefore be used to engineer the photocatalytic performance of delafossites by adjusting the alignment of band edges with chemical redox potentials and enhancing the optical activity associated with the production of photoexcited charge carriers. The photochemical activity of CuGaO2 and CuGa1–xFexO2 (x = 0.05, 0.10, 0.15, 0.20) for the reduction of CO2 has been studied. Our results show that the CuGaO2 materials investigated have an optical gap at ∼3.7 eV in agreement with previous literature reports. An optical feature is also observed at ∼2.6 eV, which is not as commonly reported due to a weak absorption cross section. Alloying at the B-site with Fe to form CuGa1–xFexO2 (x = 0.05, 0.10, 0.15, 0.20) creates new features in the visible and near-infrared region of the optical spectra for the substituted materials. Electronic density of states calculations indicate that B-site alloying with Fe creates new midgap states caused by O atoms associated with Fe substitution sites; increased Fe concentration contributes to broadening of these midgap states. The strain caused by Fe incorporation breaks the symmetry of the crystal structure giving rise to the new optical transitions noted experimentally. The photoreduction of CO2 in the presence of H2O vapor using CuGaO2 and CuGa1–xFexO2 produces CO with little evidence for other products such as H2 or hydrocarbons. The impact of Fe alloying with Ga on the band structure and photochemical activity of this delafossite system is discussed.
Insights into T‐cell dysfunction in Alzheimer's disease (2021)

T cells, the critical immune cells of the adaptive immune system, are often dysfunctional in Alzheimer's disease (AD) and are involved in AD pathology. Reports highlight neuroinflammation as a crucial modulator of AD pathogenesis, and aberrant T cells indirectly contribute to neuroinflammation by secreting proinflammatory mediators via direct crosstalk with glial cells infiltrating the brain. However, the mechanisms underlying T-cell abnormalities in AD appear multifactorial. Risk factors for AD and pathological hallmarks of AD have been tightly linked with immune responses, implying the potential regulatory effects of these factors on T cells. In this review, we discuss how the risk factors for AD, particularly Apolipoprotein E (ApoE), Aβ, α-secretase, β-secretase, γ-secretase, Tau, and neuroinflammation, modulate T-cell activation and the association between T cells and pathological AD hallmarks. Understanding these associations is critical to provide a comprehensive view of appropriate therapeutic strategies for AD.
Pharmacodynamic profile of a novel inhibitor of the hepatic glucose-6-phosphatase system (1998)

The glucose-6-phosphatase (G-6-Pase) system catalyzes the terminal enzymatic step of gluconeogenesis and glycogenolysis. Inhibition of the G-6-Pase system in the liver is expected to result in a reduction of hepatic glucose production irrespective of the relative contribution of gluconeogenesis or glycogenolysis to hepatic glucose output. In isolated perfused rat liver, S-3483, a derivative of chlorogenic acid, produced concentration-dependent inhibition of gluconeogenesis and glycogenolysis in a similar concentration range. In fed rats, glucagon-induced glycogenolysis resulted in hyperglycemia for nearly 2 h. Intravenous infusion of 50 mg . kg-1. h-1 S-3483 prevented the hyperglycemic peak and subsequently caused a further lowering of blood glucose. In 24-h starved rats, in which normoglycemia is maintained predominantly by gluconeogenesis, intravenous infusion of S-3483 resulted in a constant reduction of blood glucose levels. Intrahepatic concentrations of glucose-6-phosphate (G-6-P) and glycogen were significantly increased at the end of both in vivo studies. In contrast, lowering of blood glucose in starved rats by 3-mercaptopicolinic acid was accompanied by a reduction of G-6-P and glycogen. Our results demonstrate for the first time in vivo a pharmacologically induced suppression of hepatic G-6-P activity with subsequent changes in blood glucose levels.