gebhart/patrepeval huggingface dataset:
Monoclonal antibodies against human cytochrome <i>P</i>-450 (1986)

Conference Article| June 01 1986 Monoclonal antibodies against human cytochrome P-450 TRISTAN S. BARNES; TRISTAN S. BARNES *Department of Biochemistry, University of Aberdeen, Marischal College, Aberdeen AB9 1AS, U.K. Search for other works by this author on: This Site PubMed Google Scholar PETER M. SHAW; PETER M. SHAW †Department of Pharmacology, University of Aberdeen, Marischal College, Aberdeen AB9 1AS, U.K. Search for other works by this author on: This Site PubMed Google Scholar M. DANNY BURKE; M. DANNY BURKE †Department of Pharmacology, University of Aberdeen, Marischal College, Aberdeen AB9 1AS, U.K. Search for other works by this author on: This Site PubMed Google Scholar WILLIAM T. MELVIN WILLIAM T. MELVIN *Department of Biochemistry, University of Aberdeen, Marischal College, Aberdeen AB9 1AS, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1986) 14 (3): 621. https://doi.org/10.1042/bst0140621 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation TRISTAN S. BARNES, PETER M. SHAW, M. DANNY BURKE, WILLIAM T. MELVIN; Monoclonal antibodies against human cytochrome P-450. Biochem Soc Trans 1 June 1986; 14 (3): 621. doi: https://doi.org/10.1042/bst0140621 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: PB, phenobarbitone, 3MC, 3-methylcholanthrene © 1986 Biochemical Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.
Die Kultorganisation des Japanischen Dorfes. By Josef Kreiner. Wien: Wilhelm Braumüller, 1969. 184 pp. Index. $11.00. (1972)

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Mass-Transfer Mechanism of Alumina Ceramics under Oxygen Potential Gradients at High Temperatures (2009)

The oxygen permeability of an undoped polycrystalline α-Al2O3 wafer that was exposed to oxygen potential gradients was evaluated at temperatures up to 1973 K. Oxygen preferentially permeated through the grain boundaries of α-Al2O3. The main diffusion species, which were attributed to oxygen permeation, depended on oxygen partial pressures (PO2), forming oxygen potential gradients. Under oxygen potential gradients generated by PO2 below about 1 Pa, oxygen permeation occurred by oxygen diffusing from regions of higher PO2 to regions of lower PO2. By contrast, under oxygen potential gradients generated by PO2 above about 1 Pa, oxygen permeation proceeded by aluminum diffusing from regions of lower PO2 to regions of higher PO2. In other words, O2 molecules were adsorbed onto a surface at higher PO2 and subsequently dissociated into oxygen ions (forming Al2O3), while oxygen ions on the opposite surface at lower PO2 were desorbed by association into O2 molecules (decomposition of Al2O3). The grain-boundary diffusion coefficients of oxygen and aluminum as a function of PO2 were determined from the oxygen permeation constants.
A novel algorithm for chromatogram matching in qualitative analysis (1992)

Abstract The matching of the pattern of peaks produced during gas chromatography is of importance to many applications. At present, this task is generally performed manually, but this generates the usual problems associated with human inspection, such as a lack of objectivity and reproducibility, proneness to errors, and practical restriction of the volume of data which can reasonably be processed. This paper explores the use of a novel algorithm for automation of this task. The performance of the method on well controlled simulated data sets and real chromatograms is used to show not only how problems of manual inspection can be circumvented, but also how the existence of such a powerful method should open up the possibility of many new analyses for quality control, discrimination of varieties of sample, and the identification of specific components within a sample.
Tadalafil, a phosphodiesterase type 5 inhibitor, improves bladder blood supply and restores the initial phase of lower urinary tract dysfunction in diabetic rats (2017)

Tadalafil improves bladder blood supply and lower urinary tract function in diabetic rats. Tadalafil may be a promising drug that restores lower urinary tract dysfunction in the early phase of diabetes.
High-efficiency AlGaAs/GaAs single-quantum-well semiconductor laser with strained superlattice buffer layer (1989)

The use of a strained superlattice buffer (SSLB) layer composed of a short-period (InGaAs)(GaAs) superlattice in a lattice-matched AlGaAs/GaAs system in order to reduce the internal stress is discussed. A five-times-higher photoluminescence peak intensity has been observed from a single quantum well (SQW) with the SSLB than without the SSLB. A high-quantum efficiency, a small cavity loss, and high-output power operation have been achieved in a narrow ridge-waveguide 770-nm graded-index-separate confinement heterostructure SQW laser diode with the SSLB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Why are insulators insulating and metals conducting? (2002)

At variance with what happens in metals, the electronic charge in insulators cannot flow freely under an applied dc field, and undergoes instead static polarization. These two features arise from the difference in nature of the excitation spectra, but also from the difference in organization of the electrons in their ground state: electrons are localized in insulators and delocalized in metals. Such localization, however, is hidden in a rather subtle way in the many-body wavefunction. We review the theory of the insulating state, on the basis of electron localization, addressing on the same basis all insulators: either independent electron or correlated, either crystalline or disordered. The starting point is a 1964 milestone paper by Kohn. Significant advances occurred from 1999 onwards. These advances are deeply rooted in the modern theory of polarization: localization and polarization can be regarded as two aspects of the same phenomenon, and stem from essentially the same formalism. Starting from the many-body ground wavefunction, one defines a dimensionless complex number which vanishes in metals and is finite in insulators; in the latter case, its phase (the Berry phase) yields the macroscopic polarization, while its modulus measures localization. Conductivity features are addressed within the same theoretical scheme.
<title>Autocollimating detectors of birefringence</title> (1996)

The paper describes the devices for measuring the normal- reflection birefringence with using of the photometric, balanced, compensation and interferometric methods. The suggested scheme may be used for research of optical anisotropy in optical recording disks, inner stress in transparent solid body, birefringence of crystals and for the measuring of temperature, pressure, electrical and magnetic field strength.
Decode-Time Forensic Watermarking of AAC Bitstreams (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In digital rights-management systems, forensic watermarking complements encryption and deters the capture and unauthorized redistribution of the rendered content. In this paper, we propose a novel watermarking method which is integrated into the advanced audio coding (AAC) standard's decoding process. For predefined frequency bands, the method intercepts and modifies the scale factors, which are utilized for dequantization of spectral coefficients. It thereby modulates the short-time envelope of the bandlimited audio and embeds a watermark which is robust to various attacks, such as capture with a microphone and recompression at lower bit rates. Inclusion of watermark embedding in the AAC decoder has practically no effect on the decoding complexity. As a result, the proposed method can be integrated even into resource-constrained devices, such as portable players without any additional hardware. </para>
On the Reliability of a Weighted Composite (1943)

A general formula for the reliability of a weighted composite has been derived by which that reliability can be estimated from a knowledge of the weights whatever their source, reliabilities, dispersions, and intercorrelations of the components. The Spearman-Brown formula has been shown to be a special case of the general statement. The effect of the internal consistency or intercorrelation of the components has been investigated and the conditions defining the set of weights yielding maximum reliability shown to be that the weight of a component is proportional to the sum of its intercorrelations with the remaining components and inversely proportional to its error variance.
Kernelized Locality-Sensitive Hashing (2011)

Fast retrieval methods are critical for many large-scale and data-driven vision applications. Recent work has explored ways to embed high-dimensional features or complex distance functions into a low-dimensional Hamming space where items can be efficiently searched. However, existing methods do not apply for high-dimensional kernelized data when the underlying feature embedding for the kernel is unknown. We show how to generalize locality-sensitive hashing to accommodate arbitrary kernel functions, making it possible to preserve the algorithm's sublinear time similarity search guarantees for a wide class of useful similarity functions. Since a number of successful image-based kernels have unknown or incomputable embeddings, this is especially valuable for image retrieval tasks. We validate our technique on several data sets, and show that it enables accurate and fast performance for several vision problems, including example-based object classification, local feature matching, and content-based retrieval.
<title>The KA-93 Panoramic Camera</title> (1976)

The increasing use of pods to add supplemental reconnaissance capability to attack or other aircraft imposes, new constraints on sensor design. Available space, never great even in dedicated reconnaissance aircraft, is extremely limited. Environmental ranges and vibration levels may be more hostile in pods. Ease of maintenance, an essential requirement in any system, can be complicated in pod installations by the lack of space and a less than convenient location. To meet these new requirements, CAI developed the KA-93, a self-contained, extremely compact 24-inch focal length, prismscanning panoramic camera offering high resolution on 5-inch format film, with sector scan, forward motion compensation, autofocus, and roll stabilization. Scan prisms are fabricated using a newly developed bonding technique that eliminates the temperature sensitivity traditionally associated with L.irism panor.Lmic cameras. This feature, coupled with a fully automatic focusing mechanism ensures maximum recorded resolution under all conditions. This camera offers for the first time a reconnaissance capability previously unavailable. In addition to having been flown in remote-piloted vehicles (EPV's)pods and dedicated manned aircraft, the camera has demonstrated high reliability and ease of maintenance under day-to-day field/flight conditions.
Interfacial debond of shape memory alloy composites (2005)

A theoretical model for the prediction of interfacial behaviour is successfully developed for composites with pre-strained shape memory alloy (SMA) fiber. A two-cylinder model with a thin SMA fibre surrounding by epoxy matrix is employed for a pull-out test. The material constants and thermomechanical properties of the constituents were determined from a series of tensile tests, stress-recovery tests and strain-constrained tests. All this information is then substituted into the newly developed model so as to predict the debonding behaviour, initial debond stress and critical bonded fibre length. The maximum debond stresses at different activation temperatures are predicted and compared with the experimental results obtained from the fiber pull-out test. The good agreement between experimental findings and theoretical results warrants the application of this new developed theoretical model on the design of SMA-reinforced composites and structures.
Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin (2012)

The adenylate cyclase (CyaA) toxin, one of the virulence factors secreted by Bordetella pertussis, the pathogenic bacteria responsible for whooping cough, plays a critical role in the early stages of respiratory tract colonization by this bacterium. The CyaA toxin is able to invade eukaryotic cells by translocating its N-terminal catalytic domain directly across the plasma membrane of the target cells, where, activated by endogenous calmodulin, it produces supraphysiological levels of cAMP. How the catalytic domain is transferred from the hydrophilic extracellular medium into the hydrophobic environment of the membrane and then to the cell cytoplasm remains an unsolved question. In this report, we have characterized the membrane-interacting properties of the CyaA catalytic domain. We showed that a protein covering the catalytic domain (AC384, encompassing residues 1-384 of CyaA) displayed no membrane association propensity. However, a longer polypeptide (AC489), encompassing residues 1-489 of CyaA, exhibited the intrinsic property to bind to membranes and to induce lipid bilayer destabilization. We further showed that deletion of residues 375-485 within CyaA totally abrogated the toxin's ability to increase intracellular cAMP in target cells. These results indicate that, whereas the calmodulin dependent enzymatic domain is restricted to the amino-terminal residues 1-384 of CyaA, the membrane-interacting, translocation-competent domain extends up to residue 489. This thus suggests an important role of the region adjacent to the catalytic domain of CyaA in promoting its interaction with and its translocation across the plasma membrane of target cells.
FAB Mass Spectrometry of Au<sub>25</sub>(SR)<sub>18</sub> Nanoparticles (2008)

The molecular ion of the nanoparticle Au 25(SCH 2CH 2Ph) 18 (A 25(SR) 18) is observed at 7394 Da in fast atom bombardment (FAB, Xe atoms) ionization mass spectrometry using a 3-nitrobenzyl alcohol matrix. A distinctive pattern of positive fragment ions is evident in the mass interval 5225-7394 Da, where peaks are seen for successive mass losses equivalent to R 2S entities. Because the Au 25(SCH 2CH 2Ph) 18 nanoparticle structure is crystallographically known to consist of a centered Au 13 icosahedral core surrounded by six Au 2(SR) 3 semirings, the R 2S loses are proposed to represent serial rearrangements and decompositions of the semiring structures. Mass losses equivalent to R 2S 2 and R 2 entities also appear at the lower end of this mass interval. The most intense spectral peak, at m/ z = 5246 Da, is assigned to the fragment Au 25S 10, from which all of the CH 2CH 2Ph organic units have been cleaved but from which no gold atoms have been lost. A different pattern of fragmentation is observed at lower masses, producing ions corresponding to serial losses of one gold atom and varied numbers of sulfur atoms, which continues down to a Au 9S 2 fragment. FAB mass spectra of the Au nanoparticle are much easier to interpret than laser desorption/ionization spectra, but they show more extensive fragmentation than do electrospray and low laser pulse intensity MALDI spectra. The loss of R 2S fragmentation in FAB is distinctive and unlike that seen in the other ionization modes. The FAB spectrum for the nanoparticle Au 25(S(CH 2) 9CH 3) 18 is also reported; its fragmentation parallels that for Au 25(SCH 2CH 2Ph) 18, implying that this nanoparticle has the same surprising stellated (staples) structure.
Substrate Recognition through a PDZ Domain in Tail-Specific Protease (2000)

Tail-specific protease (Tsp) is a periplasmic enzyme that selectively degrades proteins bearing a nonpolar C-terminus. Its substrate specificity suggests that Tsp may contain a substrate recognition domain, which selectively binds to the nonpolar C-termini of substrate proteins, separate from its catalytic site. In this work, we show that substrate recognition of Tsp is mediated by a PDZ domain, a small protein module that promotes protein-protein interactions by binding to internal or C-terminal sequences of their partner proteins. Partial proteolysis by V8 protease at a single peptide bond immediately N-terminal to the PDZ domain resulted in two distinct and relatively stable fragments and complete loss of catalytic activity. Photoaffinity labeling with a fluorescent nonpolar peptide caused the covalent attachment of the peptide to a single site on the Tsp protein. Systematic deletion mutagenesis of Tsp localized the binding site to amino acids 206-307, a region that completely encompasses the putative PDZ domain (217-301). The isolated PDZ domain (amino acids 206-334) is capable of folding into a well-behaved structure and binds to a nonpolar peptide with a dissociation constant (K(D)) of 1.9 microM, similar to that of the intact Tsp protein. Site-directed mutagenesis of a surface residue at the peptide binding site of the PDZ domain, valine 229, to Glu or Gln resulted in an increase in the K(M) value but had no effect on the k(cat) value. The use of a separate substrate recognition domain such as a PDZ domain may be a general mechanism for achieving selective protein degradation.
Temporal consistent fast stereo matching for advanced driver assistance systems (ADAS) (2010)

In this paper, we present a new fast method for matching stereo images acquired by a stereo sensor embedded in a moving vehicle. The method consists in exploiting the matching results obtained in one stereo pair (frame) for computing the disparity map of the following stereo pair. This can be achieved by finding a temporal relationship, which we named association, between consecutive frames. The disparity range of the current frame is deduced from the disparity map of the preceding frame and the association between the two frames. Dynamic programming technique is considered for matching the image features. The proposed approach is tested on virtual and real stereo image sequences and the results are satisfactory. The method is fast and able to provide about 20 millions disparity maps per second on a HP Pavilion dv6700 2.1GHZ.
Microwave imaging of spinning object using orbital angular momentum (2017)

The linear Doppler shift used for the detection of a spinning object becomes significantly weakened when the line of sight (LOS) is perpendicular to the object, which will result in the failure of detection. In this paper, a new detection and imaging technique for spinning objects is developed. The rotational Doppler phenomenon is observed by using the microwave carrying orbital angular momentum (OAM). To converge the radiation energy on the area where objects might exist, the generation method of OAM beams is proposed based on the frequency diversity principle, and the imaging model is derived accordingly. The detection method of the rotational Doppler shift and the imaging approach of the azimuthal profiles are proposed, which are verified by proof-of-concept experiments. Simulation and experimental results demonstrate that OAM beams can still be used to obtain the azimuthal profiles of spinning objects even when the LOS is perpendicular to the object. This work remedies the insufficiency in existing microwave sensing technology and offers a new solution to the object identification problem.
Fourier Ptychography for Brightfield, Phase, Darkfield, Reflective, Multi-Slice, and Fluorescence Imaging (2015)

Fourier ptychography (FP) is a recently developed computational framework for high-resolution multimodal imaging. In a coherent imaging setting, FP illuminates the sample with angle-varied plane waves and captures the corresponding intensity images. The captured intensity data are then iteratively synthesized in the Fourier space to recover a widefield, high-resolution complex sample image that bypasses the frequency limit of the employed objective lens. The recovery process of FP can also be extended to incoherent imaging settings where non-uniform intensity patterns are projected on the sample and the captured data are used for image reconstruction. In this paper, we will review the progress of the FP technique and discuss different implementations including LED-array illumination, liquid-crystal-display modulation, aperture-scanning approach, lensless synthetic aperture implementation, and incoherent-imaging implementation. We will also review different imaging modalities using FP and report the new developments of darkfield and epi-illuminated imaging modalities.
Extended attention span training system (1991)

Attention Deficit Disorder (ADD) is a behavioral disorder characterized by the inability to sustain attention long enough to perform activities such as schoolwork or organized play. Treatments for this disorder include medication and brainwave biofeedback training. Brainwave biofeedback training systems feed back information to the trainee showing him how well he is producing the brainwave pattern that indicates attention. The Extended Attention Span Training (EAST) system takes the concept a step further by making a video game more difficult as the player's brainwaves indicate that attention is waning. The trainee can succeed at the game only by maintaining an adequate level of attention. The EAST system is a modification of a biocybernetic system that is currently being used to assess the extent to which automated flight management systems maintain pilot engagement. This biocybernetic system is a product of a program aimed at developing methods to evaluate automated flight deck designs for compatibility with human capabilities. The EAST technology can make a contribution in the fields of medical neuropsychology and neurology, where the emphasis is on cautious, conservative treatment of youngsters with attention disorders.
Graph Convolutional Policy Network for Goal-Directed Molecular Graph Generation (2018)

Generating novel graph structures that optimize given objectives while obeying some given underlying rules is fundamental for chemistry, biology and social science research. This is especially important in the task of molecular graph generation, whose goal is to discover novel molecules with desired properties such as drug-likeness and synthetic accessibility, while obeying physical laws such as chemical valency. However, designing models to find molecules that optimize desired properties while incorporating highly complex and non-differentiable rules remains to be a challenging task. Here we propose Graph Convolutional Policy Network (GCPN), a general graph convolutional network based model for goal-directed graph generation through reinforcement learning. The model is trained to optimize domain-specific rewards and adversarial loss through policy gradient, and acts in an environment that incorporates domain-specific rules. Experimental results show that GCPN can achieve 61% improvement on chemical property optimization over state-of-the-art baselines while resembling known molecules, and achieve 184% improvement on the constrained property optimization task.