gebhart/patrepeval huggingface dataset:
Lossless Conditional Schema Evolution (2004)

Conditional schema changes change the schema of the tuples that satisfy the change condition. When the schema of a relation changes some tuples may no longer fit the current schema. Handling the mismatch between the intended schema of tuples and the recorded schema of tuples is at the core of a DBMS that supports schema evolution. We propose to keep track of schema mismatches at the level of individual tuples, and prove that evolving schemas with conditional schema changes, in contrast to database systems relying on data migration, are lossless when the schema evolves. The lossless property is a precondition for a flexible semantics that allows to correctly answer general queries over evolving schemas. The key challenge is to handle attribute mismatches between the intended and recorded schema in a consistent way. We provide a parametric approach to resolve mismatches according to the needs of the application. We introduce the mismatch extended completed schema (MECS) which records attributes along with their mismatches, and we prove that relations with MECS are lossless.
Butyrate‐stable monosaccharide derivatives induce maturation and apoptosis in human acute myeloid leukaemia cells (1998)

The rapid degradation and subsequent lack of efficacy of n-butyric acid in vivo has been improved by the synthesis of monosaccharide stable pro-drugs of butyric acid. We studied the effects of D1 (O-n-butanoyl-2,3-O-isopropylidene-alpha-D-mannofuranoside), G1 (1-O-n-butanoyl-D,L-xylitol), and F1 (1-O-n-butanoyl 2,3-O-isopropylidene-D,L-xylitol) on the maturation and proliferation of AML cell lines HL 60 and FLG 29.1 and of purified blast cells from 10 cases of de novo acute myeloid leukaemia (AML). AML cell maturation was measured by surface antigen expression, morphology and cytochemistry. Toxicology in mice was also evaluated (DL50 1000 mg/kg). In HL 60 cells G1 and D1 increased the expression of CD15 and CD11a (presenting 62% of promyelo-metamyelocytes), and in 7/10 cases of primary AMLs that of CD11a, CD11b, CD15, and myeloperoxidase. D1, G1 and F1 induced a dose-dependent inhibition of tritiated thymidine uptake. Apoptosis (evaluated by flow cytometry and agarose gel electrophoresis) was induced in AML blasts by D1 and F1 (79% and 94% respectively for HL 60 cells) and, with less effect, by G1 (27%). The persistence of maturative and apoptotic activity in these new pro-drugs of butyric acid, hydrolysed only inside the tumour cell, suggests a possible use in differentiation therapy of myelodysplastic syndromes and AMLs.
Classification, Investigation, and Management of Midfoot Sprains (2002)

Weightbearing radiographs and bone scintigrams are sensitive, reproducible, and relatively inexpensive methods of investigation of these injuries. Restoration and maintenance of the anatomic alignment of the Lisfranc joint is the key to appropriate treatment of injury to the midfoot.
The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans (2011)

Kisspeptin-10 stimulates gonadotropin release in men as well as women during the preovulatory phase of menstrual cycle but fails to stimulate gonadotropin release in women during the follicular phase. The sexual dimorphism of the responsiveness of healthy men and women to kisspeptin-10 administration has important clinical implications for the potential of kisspeptin-10 to treat disorders of reproduction.
Statistical Simulator for Block Coded Channels with Long Residual Interference (2007)

In this paper, we present a simple statistical simulation technique for channels with long memory operating under coded data. The proposed technique employs a divide-and-conquer approach, both at the level of the channel response and the individual codeword. We introduce an efficient algorithm for parity tracking during the generation and combining of the voltage distributions computed in individual sub-problems. The resulting computational complexity increases linearly both with the channel and the codeword length, keeping the number of parity bits constant. The complexity increases exponentially with the number of parity bits in a codeword. Thus, the technique is of most use for high-rate codes. Finally, the technique is applied to examine the effect of coding on high-speed links which operate at BERs smaller than 1e-15 and where residual interference typically spans several hundreds of bits. This simulator enables systematic evaluation of power-performance trade-offs in introducing error correction/detection codes into high-speed link systems.
Conflating Rules, Norms, and Ethics in Intercollegiate Forensics (2005)

This paper explores the concepts of rules, norms, and ethics as they pertain to intercollegiate forensic competition. The perspective is taken that these concepts tend to be conflated. Definitions of rules and ethics are drawn primarily from the National Forensics Association (NFA). The pertinent literature is reviewed, methods are explained, and results are reported and discussed. The conclusions pertain to the idea that forensics coaches and students alike are hesitant to accept universal rules and ethics, and prefer more contextualized standards. Suggestions for future research are also offered.
Distributed heterogeneous knowledge data base for control system design: multiagent development and support (2002)

It is proposed to construct an automatic control system design environment with engineering knowledge-based management as an integral part. The control design environment consists of a set of control design modules and a number of control systems models that have to be designed or are to be designed. The knowledge objects are distributed in multiple heterogeneous data sources. A multi-agent system approach to the design of resource management components in the heterogeneous environment is discussed. Cooperative agents communicate through networked environment. The database structure is determined dynamically by XML tools. Meta-knowledge is described as an RDF-file that makes it possible for intelligent retrieval of information. Communications are established using CORBA.
Effects of ionotropic glutamate receptor blockade and 5-HT1A receptor activation on spreading depression in rat neocortical slices (1999)

The effect of the AMPA antagonist NBQX (10 microM), NMDA antagonist ketamine (100 microM) and 5-HT1A agonist 8-OH-DPAT (1, 10 and 100 microM) on the properties of a KCl-induced spreading depression (SD) was studied in parietal cortical slices of adult rats. Whereas NBQX did not significantly affect the SD, ketamine significantly (p < 0.01) reduced the amplitude of the first SD peak (12.8 +/- 4.6 mV) and blocked the second SD peak when compared with the controls (19.8 +/- 5.2 mV and 25 +/- 5 mV, respectively). Ketamine also decreased the SD duration at half maximal amplitude from 34.9 +/- 12.4 s to 22.2 +/- 12 s (p < 0.05). 8-OH-DPAT attenuated the duration of the SD from 42 +/- 15.6 s to 21.2 +/- 10.6 s (p < 0.05, 100 microM). These data indicate that not only NMDA receptor blockade, but also activation of the 5-HT1A receptor attenuates the SD and may be beneficial in the reduction of ischemic injury following focal cerebral ischemia.
Measurement and modeling of propagation losses in brick and concrete walls for the 900-MHz band (2003)

The prediction of wall losses is a fundamental aspect in the planning of cellular systems. The broad variety of building materials and construction codes makes accurate attenuation prediction very difficult without the support of specific construction data or measurements. In this paper, the attenuation and equivalent electric parameters /spl epsiv/ and /spl sigma/ of brick and doubly reinforced concrete walls are estimated for the 900-MHz band by fitting simple ray tracing models to empirical transmission data. The measurement setup is described, and extensive experimental results justifying the quasioptical modeling are presented.
The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells (2005)

Our findings indicate that ezrin is required for breast cancer metastasis, and that c-Src and phosphatidylinositol 3-kinase/Akt are effectors of ezrin in the cell motility and invasion stages of the metastatic process. Together, these results suggest that blocking ezrin function may represent a novel and effective strategy for preventing breast cancer metastasis.
An integrated services token-controlled ring network (1989)

A ring protocol is proposed that allows voice and data traffic to coexist within the ring. This ring has the following distinct features: (1) it allows synchronous traffic such as voice and video to have a definite access to the channel within each packetization period (or frame); (2) it allows data messages to have a higher channel access priority provided that the synchronous traffic is not delayed by more than one frame; (3) it supports variable rate data circuits. Simulation results show that the data-message delay is much smaller than for other integrated services schemes. Urgent messages can be transmitted with a higher priority over voice. Since the voice packet delay is bounded within one packetization period, no time-stamping is needed and the voice loss can be completely avoided by reserving a sufficient number of slots. Continual speech reception is possible by synchronizing the speech regeneration process to the end of each frame. Since the ring is synchronized, gateway switching to external circuit-switched and packet-switched networks is very simple.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor‐β receptor inhibitor on extravasation of nanoparticles from neovasculature (2008)

There are a number of kinase inhibitors that regulate components of the neovasculature. We previously reported the use of transforming growth factor (TGF)-beta inhibitor on neovasculature in stroma-rich tumor models to increase the intratumoral distribution of nanoparticles. Here, we compared the effects of two other kinase inhibitors, imatinib and sorafenib, with TGF-beta inhibitor (LY364947) on extravasation of a modeled nanoparticle, 2 MDa dextran. We first used a mouse model of neoangiogenesis, the Matrigel plug assay, to compare neovasculature formed inside of and around Matrigel plugs (intraplug and periplug regions, respectively). Intraplug vasculature was more strongly pericyte covered, whereas periplug vasculature was less covered. In this model, TGF-beta inhibitor exhibited the most potent effect on intraplug vasculature in increasing the extravasation of dextran, whereas sorafenib had the strongest effect on periplug vasculature. Although imatinib and TGF-beta inhibitor each reduced pericyte coverage, imatinib also reduced the density of endothelium, resulting in a decrease in overall delivery of nanoparticles. These findings were confirmed in two tumor models, the CT26 colon cancer model and the BxPC3 pancreatic cancer model. The vasculature phenotype in the CT26 model resembled that in the periplug region, whereas the latter resembled that in the intraplug region. Consistent with this, sorafenib most potently enhanced the accumulation of nanoparticles in the CT26 model, whereas TGF-beta inhibitor did in the BxPC3 model. In conclusion, the appropriate strategy for optimization of tumor vasculature for nanoparticles may differ depending on tumor type, and in particular on the degree of pericyte coverage around the vasculature.
A rough comparison of the IETF and ATM service models (1995)

There is much in common between the models of traffic management being devised by the IETF and ATM Forum working groups. The authors' goal is to demonstrate that because of this convergence, there are a number of ways that each can take advantage of the other. The authors discuss service models, link sharing, network provision models, traffic service class hierarchies, borrowing and replacement strategies, delays and throughput, ordering and routing with particular application to the Internet.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Enhanced charge-transport in surfactant-free PbSe quantum dot films grown by a laser-assisted spray process (2009)

A laser-assisted spray process was developed to deposit surfactant-free PbSe quantum dot (QD) films directly on a substrate. These QDs are in close contacts with each other, forming a percolation path for charge transport. Absorption spectroscopy confirmed the quantum confinement of the deposited particles. Room temperature current-voltage measurements across a 2 μm tunnel junction formed by the QDs produced a power-law dependence of the form I∝V2.25, which describes a percolation path of dimensionality slightly above two dimensions. Temperature dependent conductance studies showed thermally activated transport at high temperatures and temperature independent tunneling, followed by previously unobserved metallic conduction at low temperatures.
[Differences in income distribution data between the population census and household surveys (PNAD): conceptual and operational aspects]. (1991)

"The [purpose] of this article is to explain the main differences between the concepts and the [collection procedures] of income distribution data used in [the] 1980 demographic census and in [the] 1979 and 1981 household surveys in Brazil. The article also comments [on] some differences about the data information on income distribution produced by census and household surveys." (SUMMARY IN ENG)
Advanced Video Coding for Next-Generation Multimedia Services (2013)

This book aims to bring together recent advances and applications of video coding. All chapters can be useful for researchers, engineers, graduate and postgraduate students, experts in this area, and hopefully also for people who are generally interested in video coding. The book includes nine carefully selected chapters. The chapters deal with advanced compression techniques for multimedia applications, concerning recent video coding standards, high efficiency video coding (HEVC), multiple description coding, region of interest (ROI) coding, shape compensation, error resilient algorithms for H.264/AVC, wavelet-based coding, facial video coding, and hardware implementations. This book provides several useful ideas for your own research and helps to bridge the gap between the basic video coding techniques and practical multimedia applications. We hope this book is enjoyable to read and will further contribute to video coding.
Formation and Thermal Properties of Amorphous Ti<sub>40</sub>Cu<sub>40</sub>Ni<sub>10</sub>Al<sub>10</sub>Alloy by Mechanical Alloying (2009)

The amorphization process and the thermal properties of amorphous Ti<TEX>$_{40}$</TEX>Cu<TEX>$_{40}$</TEX>Ni<TEX>$_{10}$</TEX>Al<TEX>$_{10}$</TEX> powder during milling by mechanical alloying were examined by X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and transmission electron microscopy (TEM). The chemical composition of the samples was examined by an energy dispersive X-ray spectrometry (EDX) facility attached to the scanning electron microscope (SEM). The as-milled powders showed a broad peak (2<TEX>$\theta$</TEX> = 42.4<TEX>$^{\circ}$</TEX>) with crystalline size of about 5.0 nm in the XRD patterns. The entire milling process could be divided into three different stages: agglomeration (0 < t<TEX>$_m$</TEX> <TEX>$\leq$</TEX> 3 h), disintegration (3 h < t<TEX>$_m$</TEX> <TEX>$\leq$</TEX> 20 h), and homogenization (20 h < t<TEX>$_m$</TEX> <TEX>$\leq$</TEX> 40 h) (t<TEX>$_m$</TEX>: milling time). In the DSC experiment, the peak temperature T<TEX>$_p$</TEX> and crystallization temperature T<TEX>$_x$</TEX> were 466.9<TEX>$^{\circ}C$</TEX> and 444.3<TEX>$^{\circ}C$</TEX>, respectively, and the values of T<TEX>$_p$</TEX>, and T<TEX>$_x$</TEX> increased with a heating rate (HR). The activation energies of crystallization for the as-milled powder was 291.5 kJ/mol for T<TEX>$_p$</TEX>.
Is there enough evidence with evolocumab and alirocumab (antibodies to proprotein convertase substilisin-kexin type, PCSK9) on cardiovascular outcomes to use them widely? (2015)

In OSLER and ODYSSEY LONG TERM, there were very few cardiovascular outcomes, but the trials do suggest that evolocumab and alirocumab may reduce these outcomes. However, there are also some safety concerns with both of these antibodies. Large clinical outcome trials are underway with both evolocumab and alirocumab, which will probably clarify both the safety concerns and any cardiovascular benefits with these antibodies. In our opinion, these antibodies may be suitable for use in subjects with familial hypercholesterolemia, who are uncontrolled with their present medications, provided intensive safety and cardiovascular monitoring is being undertaken. However, evolocumab and alirocumab should be used with caution in other subjects, until outcome studies in higher numbers of subjects have shown acceptable safety and cardiovascular profiles.
Structure of a peptide oxazolone: 2-(1'-benzyloxycarbonylamino-1'-methylethyl)-4,4-dimethyl-5-oxazolone (1980)

C16H20N204, monoclinic, P21, a = 6.270 (1),b= 11.119(3),c= ll.640(4)A, fl= 100.7 (2)°,Dm = 1-27 (flotation), Dc = 1-26 Mg m -3, Z = 2. The structure has been refined to a final R value of 0.041 for 1584 independent counter-measured reflections. The oxazolone ring in the molecule is nearly planar. The exocyclic O atom is 0.065 A out of the plane defined by the other four atoms in the ring belonging to the lactone group. The difference in length between the two
adjacent C-O bonds in the ring is small, but significant.
The crystal structure is stabilized by van der Waals interactions and a N--H... N hydrogen bond.
Oral hypoglycemic agents: insulin secretagogues, α-glucosidase inhibitors and insulin sensitizers (2001)

In this review we present the agents that are in use in the treatment of type 2 diabetes. Sulfonylureas of the 1st and 2nd generation increase insulin secretion but can induce hyperinsulinemia and sometimes prolonged hypoglycemia. Glimepiride is a new 3rd generation sulfonylurea with some advantages over the other members of this group, such as a lower risk of hypoglycemia, no interaction with cardiovascular KATP-channels and a possibility that it may increase insulin sensitivity. There are also newer insulin secretagogues (such as neteglinide and repaglinide) with a rapid onset of action on the beta-cell, therefore inducing a more physiological profile of insulin secretion during meals. The category of insulin sensitizers includes metformin and thiazolidinediones. Metformin effectively reduces hyperglycemia, hyperlipidemia and macroangiopathy in patients with type 2 diabetes. This agent increases the sensitivity of the liver and peripheral tissues to insulin and, therefore, it could be considered as a drug of choice for the prevention of type 2 diabetes. Thiazolidinediones (rosiglitazone and pioglitazone) increase the sensitivity of the tissues to insulin. This mechanism of action makes them powerful therapeutic tools for the treatment of type 2 diabetes (and possibly other insulin resistant states) either alone or in combination with other oral agents. The category of agents that interfere with the absorption of glucose and lipids includes alpha-glucosidase inhibitors (acarbose and miglitol) and lipase inhibitors (or-listat). alpha-Glucocidase inhibitors improve the time relationship between plasma insulin and glucose increases after a meal. Therefore, these agents may be used in the treatment of patients with type 2 diabetes, either alone at a very early stage of this disease (when insulin secretion is still adequate), or in combination with insulin secretagogues. alpha-Glucosidase inhibition may also prove useful as a supplement to insulin therapy in patients with type 1 diabetes mellitus. The inhibitor of gastrointestinal lipase orlistat may prove a useful adjunct to hypocaloric diets in patients with type 2 diabetes and obesity.
1 alpha,25-Dihydroxy-20-epi-vitamin D3: an extraordinarily potent inhibitor of leukemic cell growth in vitro (1994)

We have evaluated seven recently synthesized vitamin D3 analogs for their abilities to inhibit clonal growth of leukemic cells, to induce leukemic cell differentiation, to stimulate clonal growth of normal myeloid committed stem cells, and to transactivate a reporter gene having a 1,25(OH)2D3 response element (VDRE). The 1,25(OH)2–20-epi-D3 showed extraordinary activity; at 10(-11) mol/L it inhibited clonal growth of 87% of HL-60 myeloblast cells, 60% of S-LB1 cells (human T- cell lymphotropic virus type 1 [HTLV-1]-immortalized human T-lymphocyte cell line) and 50% of leukemic clonogenic cells (colony-forming unit- leukemia) obtained from patients with acute myelogenous leukemia. No effect of either 1,25(OH)2D3 or 1,25(OH)2–20-epi-D3 was observed on the clonal proliferation of an HTLV-1-immortalized human T-lymphocyte cell line (Ab-VDR) having nonfunctional 1,25 (OH)2D3 cellular receptors (VDR). The abilities of 1,25(OH)2–20-epi-D3 to induce differentiation of HL-60 cells, as measured by generation of superoxide and nonspecific esterase production, was less than its antiproliferative activities. This analog stimulated colony-forming unit-granulocyte-macrophage growth from normal human bone marrow. To gain insights into the remarkable antileukemic activities of 1,25(OH)2–20-epi-D3, we examined its ability to enter HL-60 cells, bind to the VDR, and interact with a transfected VDRE attached upstream of a TK promoter-driven reporter gene (chloramphenicol acetyl transferase [CAT]). The 1,25(OH)2–20-epi- D3 potently increased CAT activity (> 16-fold, as compared with cells transfected with control receptor having no VDRE); paradoxically, 1,25(OH)2–20-epi-D3 was of equal potency to 1,25(OH)2D3 in transactivating the VDRE-containing reporter gene, even though the analog had a 1,000-fold greater antileukemic effect as compared with 1,25(OH)2D3. In summary, we have identified an extremely potent 1,25(OH)2D3 analog with antiproliferative and differentiating effects on leukemic cells and that may be clinically useful. This analog appears to generate biologic responses via the classical VDR pathway, but further studies are required to elucidate the mechanism by which this analog produces its prominent activities.
Structured nucleosome fingerprints enable high-resolution mapping of chromatin architecture within regulatory regions (2015)

Transcription factors canonically bind nucleosome-free DNA, making the positioning of nucleosomes within regulatory regions crucial to the regulation of gene expression. Using the assay of transposase accessible chromatin (ATAC-seq), we observe a highly structured pattern of DNA fragment lengths and positions around nucleosomes in Saccharomyces cerevisiae, and use this distinctive two-dimensional nucleosomal "fingerprint" as the basis for a new nucleosome-positioning algorithm called NucleoATAC. We show that NucleoATAC can identify the rotational and translational positions of nucleosomes with up to base-pair resolution and provide quantitative measures of nucleosome occupancy in S. cerevisiae, Schizosaccharomyces pombe, and human cells. We demonstrate the application of NucleoATAC to a number of outstanding problems in chromatin biology, including analysis of sequence features underlying nucleosome positioning, promoter chromatin architecture across species, identification of transient changes in nucleosome occupancy and positioning during a dynamic cellular response, and integrated analysis of nucleosome occupancy and transcription factor binding.