gebhart/patrepeval huggingface dataset:
Eosinophil transendothelial migration induced by cytokines. III. Effect of the chemokine RANTES. (1994)

Selective eosinophil recruitment occurs after experimental Ag challenge and in tissue sites of allergic diseases. The mechanisms of selective eosinophil migration are still unknown. In our study, we examined the ability of chemokines to induce transendothelial migration (TEM) of eosinophils in vitro. Among the chemokines tested, only RANTES induced eosinophil TEM. RANTES failed to induce TEM of neutrophils. Interestingly, IL-8 induced neutrophil TEM and had no effect on eosinophil TEM. RANTES-induced TEM was concentration-dependent and was inhibited by Abs directed against the beta 2 integrin CD18. When IL-1-activated endothelial cells were utilized, RANTES-induced TEM also involved the eosinophil beta 1 integrin VLA-4. RANTES did not increase eosinophil adhesion to either resting or IL-1-activated endothelial cells, nor did the chemokine increase CD11b or decrease L-selectin expression. A gradient of RANTES appears to be required for eosinophil TEM. Pre-exposure of eosinophils to IL-5 dramatically potentiated the TEM response to RANTES. These findings suggest that the chemokine RANTES is a potent and selective inducer of eosinophil TEM. Because RANTES appears to be produced in vivo during allergic reactions or in allergic diseases, we speculate that these findings may have some direct relevance to the mechanism of selective eosinophil recruitment in vivo in humans.
Design and Stability of Cu(In,Ga)Se2-Based Solar Cell Modules (2002)

Cu(In,Ga)Se2 (CIGS) is one of the most promising semiconductor compounds for large-scale production of efficient, low-cost thin film solar cells, and several research institutes have announced their plans for CIGS production lines. But for the CIGS technology to become a commercial success, a number of issues concerning manufacturability, product definition, and long-term stability require further attention. Several studies indicate that CIGS-based modules are stable over many years in field operation. At the same time, it is shown in the present work that they may have difficulties in passing standard accelerated lifetime test procedures like the IEC 1646 damp heat test. In particular, CIGS modules are sensitive to humidity penetrating through the module encapsulation, which will increase the resistive losses in the front contact and cause severe corrosion of the back contact. It is also shown that cells experience degradation in both voltage and fill factor, and the causes of these effects are addressed. By concentrating the light falling onto a solar cell, the device will deliver a higher power output per illuminated absorber area, which can lower the electricity production costs. For CIGS-based solar cells, low-concentrated illumination could be an economically viable approach. In this work it is shown that the yearly performance of a photovoltaic system with CIGS modules can be significantly improved at a moderate cost by using parabolic aluminum mirrors as concentrating elements. However, in order to avoid detrimental power losses due to high temperatures and current densities, the modules need to be designed for the higher light intensity and to be sufficiently cooled during operation. A design where the front contact of the module is assisted by a metal grid has shown promising results, not only for concentrated illumination but also for normal operation. The benefits are enhanced window processing tolerance and throughput, as well as improved degrees of freedom of the module geometry.
Magnifying Endoscopy, Stereoscopic Microscopy, and the Microvascular Architecture of Superficial Esophageal Carcinoma (2002)

Observation of the microvascular architecture of superficial esophageal carcinoma is useful in the diagnosis of the depth of invasion.
Towards the capability of providing power-area-delay trade-off at the register transfer level (1998)

This paper presents a new register-transfer level (RT-level) power estimation technique based on technology decomposition. Given the Boolean description of a circuit function, the power consumption of two typical circuit implementations, namely the minimum area implementation and the minimum delay implementation, are estimated, respectively. This provides a capability of obtaining a full power-delay-area trade-off curve at the RT level. Our method makes it possible to capture the structural and/or functional information of a circuit without going through actual gate-level implementation. Experimental results show that the accuracy is very reasonable.
Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5‐fluorouracil‐based drugs (2006)

The development of a diagnostic method for predicting the therapeutic efficacy or toxicity of anticancer drugs is a critical issue. We carried out a gene expression analysis to identify genes whose expression profiles were correlated with the sensitivity of 30 human tumor xenografts to 5-fluorouracil (5-FU)-based drugs (tegafur + uracil [UFT], tegafur + gimeracil + oteracil [S-1], 5'-deoxy-5-fluorouridine [5'-DFUR], and N4-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine [capecitabine]), as well as three other drugs (cisplatin [CDDP], irinotecan hydrochloride [CPT-11], and paclitaxel) that have different modes of action. In the present study, we focused especially on the fluoropyrimidines. The efficacy of all anticancer drugs was assayed using human tumor xenografts in nude mice. The mRNA expression profile of each of these xenografts was analyzed using a Human Focus array. Correlation analysis between the gene expression profiles and the chemosensitivities of seven drugs identified 39 genes whose expression levels were correlated significantly with multidrug sensitivity, and we suggest that the angiogenic pathway plays a pivotal role in resistance to fluoropyrimidines. Furthermore, many genes showing specific correlations with each drug were also identified. Among the candidate genes associated with 5-FU resistance, the dihydropyrimidine dehydrogenase mRNA expression profiles of the tumors showed a significant negative correlation with chemosensitivity to all of the 5-FU based drugs except for S-1. Therefore, the administration of S-1 might be an effective strategy for the treatment of high dihydropyrimidine dehydrogenase-expressing tumors. The results of the present study may enhance the prediction of tumor response to anticancer drugs and contribute to the development of tailor-made chemotherapy.
Biofilms, Antimicrobial Resistance, and Airway Infection (2002)

The use of susceptibility testing to identify appropriate antimicrobial agents has long been an important element of the practice of infectious-disease medicine. In most clinical settings, the finding that a strain of bacteria is susceptible to a specific antibiotic is a reliable indicator of the effectiveness of that drug. An exception is the treatment of pulmonary infection in patients with cystic fibrosis. Once chronic Pseudomonas aeruginosa infection is established in the lungs of these patients, the bacteria are rarely, if ever, eradicated despite treatment with combinations of antimicrobial agents with demonstrated potency in vitro. Even direct administration of aerosolized antibiotics . . .
Towards a Quaternion Complex Logarithmic Number System (2011)

The well-known generalization of real to complex arithmetic (two reals) extends further to more obscure quaternion arithmetic (four reals), which has applications in signal processing, aerospace, graphics and virtual reality. Quaternion multiplication implements 3D rotation, but is expensive (usually 16 floating-point multiplications and 12 additions). This paper proposes an alternative quaternion representation using logarithms to reduce multiplication cost. The real Logarithmic Number System (LNS) allows fast and inexpensive multiplication and division in embedded and FPGA-based systems. Recent advances in the Complex LNS (CLNS) have made fast log-polar complex representation affordable. Although the quaternion logarithm function is also well-defined, it is not useful to simplify multiplication (in the same way real and complex logarithms are) because quaternion multiplication is not commutative but quaternion addition is. To overcome this, we propose a novel Quaternion Complex (QCLNS) representation using a pair of CLNS numbers. This representation implements quaternion multiplication using only the theoretical minimum, of 8 LNS multipliers (i.e., fixed-point adders) and two CLNS adders. Because CLNS numbers are more compact than ordinary rectangular complex representation, single-precision QCLNS occupies 10.9 percent less memory than conventional quaternion representation. Extrapolating conventional LNS and floating-point synthesis data from Fu et al., QCLNS saves on average 10 percent of FPGA resources for precisions between 13 and 45 bits.
Information arbitrage across multi-lingual Wikipedia (2009)

The rapid globalization of Wikipedia is generating a parallel, multi-lingual corpus of unprecedented scale. Pages for the same topic in many different languages emerge both as a result of manual translation and independent development. Unfortunately, these pages may appear at different times, vary in size, scope, and quality. Furthermore, differential growth rates cause the conceptual mapping between articles in different languages to be both complex and dynamic. These disparities provide the opportunity for a powerful form of information arbitrage--leveraging articles in one or more languages to improve the content in another. Analyzing four large language domains (English, Spanish, French, and German), we present Ziggurat, an automated system for aligning Wikipedia infoboxes, creating new infoboxes as necessary, filling in missing information, and detecting discrepancies between parallel pages. Our method uses self-supervised learning and our experiments demonstrate the method's feasibility, even in the absence of dictionaries.
A New Variable Microwave Attenuator (Correspondence) (1970)

The described variable attenuator utilizes p-i-n diodes and three-port hybrids. Two arrangements of the diodes are investigated. The corresponding attenuators have basically different performances. An experimental device was built in stripline technique and a measured attenuation variable from 0 to 28 dB over the entire X-band was obtained.
Importance of matrix: Analyte ratio for buffer tolerance using 2,5-dihydroxybenzoic acid as a matrix in matrix-assisted laser desorption/ionization-fourier transform mass spectrometry and matrix-assisted laser desorption/ionization-time of flight (1998)

Many biological samples destined for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) contain buffers. The presence of these buffers often inhibits the ability to obtain spectra. Here, the results of a study of the effects of six different buffers on spectra of three representative small proteins are reported utilizing 2,5-dihydroxybenzoic acid as matrix. These proteins, bovine insulin, cytochrome c, and bovine albumin have masses from approximately 5000 to 66,000 Da. Three different sample preparation techniques were investigated: aerospray, dried-drop, and acetone redeposition. Both MALDI Fourier transform and time-of-flight mass spectrometry results show that buffer tolerance of MALDI-MS samples depends upon several factors, including the relative amount of the buffer in the MALDI matrix, as well as the identity of the specific buffer. Furthermore, the rate at which buffer tolerance decreases as buffer concentration is increased varies from buffer to buffer. The current results reveal that, at very high matrix:analyte ratios, buffer tolerance of MALDI is dramatically greater than concluded in previous literature reports.
Coset partitioning for the 4-PSK space-time trellis codes (2009)

In this paper, we present a simple method to design the best 4-PSK space-time trellis codes (STTCs) for any number of transmit antennas. This method called ldquocoset partitioningrdquo is based on the set partitioning proposed by Ungerboeck for the multiple input multiple output (MIMO) systems. Thanks to this method, an exhaustive search is no more required to find the best codes. Thus, new 4-PSK codes are designed and compared with good known codes. The simulation results show that these new codes outperform the existing best codes.
Microarray Analysis of Eosinophils Reveals a Number of Candidate Survival and Apoptosis Genes (2001)

The increase in eosinophils at the site of antigen challenge has been used as evidence to suggest that this cell type plays a role in the pathophysiology of asthma. Aberrant production of several different cytokines, particularly interleukin (IL)-5, has been shown to result in eosinophilia. IL-5 influences the development and maturation of eosinophils in a number of different ways. Of note is the ability of IL-5 to act as a survival factor for eosinophils specifically inhibiting apoptosis. The precise mechanism by which IL-5 exerts its effect remains obscure. We used microarray technologies to investigate the changes in the messenger RNA expression profile of eosinophils after treatment with IL-5. Using the Affymetrix Hu6800 chip, a total of 80 genes were observed to be regulated by 2-fold or greater. Many of the genes previously identified as regulated by IL-5 were regulated in our microarray experiments. Of the 73 genes found to be upregulated, many were shown to play a role in adhesion, migration, activation, or survival of eosinophils or hematopoietic cells, whereas the function of others was unknown. To facilitate the identification of genes that govern the apoptosis and survivability of eosinophils, we used an alternative cellular model, TF1.8 cells, whose survival was also dependent on IL-5. Comparison of these models identified four genes, Pim-1, DSP-5 (hVH3, B23), CD24, and SLP-76, whose regulation was similarly coordinated in both systems. Identification of Pim-1 and SLP-76 as regulated by IL-5 led us to suggest a direct role for these proteins in the IL-5 signaling pathway in eosinophils. The tissue distribution of these genes demonstrated that Pim-1 and SLP-76 were relatively restricted to the eosinophil compared with their expression in brain, bone marrow, kidney, liver, and lung. By contrast, DSP-5 and CD24 were confirmed as ubiquitous in their expression by microarray.
Seed coat permeability in semi-hard snap bean seeds: its influence on imbibitional chilling injury (1987)

SummaryThe susceptibility of a snap bean (Phaseolus vulgaris) breeding line with the semi-hard seed (SHS) characteristic to imbibitional chilling injury was studied. SHS with greater than 10% initial moisture content imbibed water readily. However, at 6% and 8% moisture levels 18 and 6 days were required for full imbibition, respectively. Seed coat permeability of SHS was readily reversible and was moderated by the seed storage relative humidity. Seeds of cv Bush Blue Lake 47 and cv Burly and SHS were adjusted to 12% moisture, and found to be tolerant to imbibitional chilling injury. At 8% moisture only SHS was not susceptible to chilling and this was attributed to slow hydration rates. Mechanical damage of SHS with 8% moisture resulted in increased hydration rates, solute leakage and chilling injury. An improvement in field seedling emergence was measured for SHS compared to the Bush Blue Lake 47 and Burly. SHS exhibited good field emergence at both 8% and 12% moisture.
Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-alpha toxin antibody fragment and alpha toxin (2013)

Staphylococcus aureus alpha toxin (AT) has been crystallized in complex with the Fab fragment of a human antibody (MEDI4893). This constitutes the first reported crystals of AT bound to an antibody. The monoclinic crystals belonged to space group P2₁, with unit-cell parameters a=85.52, b=148.50, c=93.82 Å, β=99.82°. The diffraction of the crystals extended to 2.56 Å resolution. The asymmetric unit contained two MEDI4893 Fab-AT complexes. This corresponds to a crystal volume per protein weight (VM) of 2.3 Å3 Da(-1) and a solvent content of 47%. The three-dimensional structure of this complex will contribute to an understanding of the molecular basis of the interaction of MEDI4893 with AT. It will also shed light on the mechanism of action of this antibody, the current evaluation of which in the field of S. aureus-mediated diseases makes it a particularly interesting case study. Finally, this study will provide the three-dimensional structure of AT in a monomeric state for the first time.
Hypermutation Is a Key Factor in Development of Multiple-Antimicrobial Resistance in<i>Pseudomonas aeruginosa</i>Strains Causing Chronic Lung Infections (2005)

Pseudomonas aeruginosa is the most relevant pathogen producing chronic lung infections in patients with chronic underlying diseases such as cystic fibrosis (CF), bronchiectasis, and chronic obstructive pulmonary disease (COPD). Hypermutable (or mutator) P. aeruginosa strains, characterized by increased (up to 1,000-fold) spontaneous mutation rates due to alterations of the DNA mismatch repair (MMR) system have been found at high frequencies in the lungs of CF patients, but their role in other chronic processes is still unknown. Sixty-two P. aeruginosa isolates from 30 patients with underlying non-CF chronic respiratory diseases (22 with bronchiectasis and 8 with COPD) and documented chronic infection were studied. Antibiotic susceptibility profiles and mutation frequencies were determined, and complementation assays using the cloned wild-type mutS gene and molecular epidemiology studies (pulsed-field electrophoresis, [PFGE]) were performed with these strains. Thirty-three (53%) of the isolates were hypermutable, and 17 (57%) of the 30 patients were colonized by hypermutable strains. Strains from 11 of the 17 patients were found to be defective in the MMR mutS gene by complementation assays. Interpatient transmission of strains was ruled out by PFGE. Multiple-antimicrobial resistance was documented in 42% of the hypermutable strains in contrast to 0% resistance in the nonhypermutable strains (P < 0.0001). Hypermutable P. aeruginosa strains are extremely prevalent in chronic infections in contrast to what has been described in acute processes, suggesting a role of hypermutation in bacterial adaptation for long-term persistence. Furthermore, hypermutation is found to be a key factor for the development of multiple-antimicrobial resistance, and therefore these findings are expected to have important consequences for the treatment of chronic infections.
Electroreductive Synthesis of Polysilanes, Polygermanes, and Related Polymers with Magnesium Electrodes<sup>1</sup> (1999)

The electroreduction of alkylaryldichlorosilane carried out with Mg cathode and anode in a single compartment cell gave high molecular weight poly(alkylarylsilane) (M(n) = 5200-31000, M(w)/M(n) = 1.4-1.8) in 5-79% yield. The effects of electrode material, monomer concentration, amount of supplied electricity, and ultrasound were investigated. This electroreductive method was also successfully applied to the synthesis of polygermanes, silane-geramane copolymers, and also poly[p-(disilanylene)phenylenes].
N-gram Language Modeling using Recurrent Neural Network Estimation (2017)

We investigate the effective memory depth of RNN models by using them for $n$-gram language model (LM) smoothing. Experiments on a small corpus (UPenn Treebank, one million words of training data and 10k vocabulary) have found the LSTM cell with dropout to be the best model for encoding the $n$-gram state when compared with feed-forward and vanilla RNN models. When preserving the sentence independence assumption the LSTM $n$-gram matches the LSTM LM performance for $n=9$ and slightly outperforms it for $n=13$. When allowing dependencies across sentence boundaries, the LSTM $13$-gram almost matches the perplexity of the unlimited history LSTM LM. LSTM $n$-gram smoothing also has the desirable property of improving with increasing $n$-gram order, unlike the Katz or Kneser-Ney back-off estimators. Using multinomial distributions as targets in training instead of the usual one-hot target is only slightly beneficial for low $n$-gram orders. Experiments on the One Billion Words benchmark show that the results hold at larger scale: while LSTM smoothing for short $n$-gram contexts does not provide significant advantages over classic N-gram models, it becomes effective with long contexts ($n > 5$); depending on the task and amount of data it can match fully recurrent LSTM models at about $n=13$. This may have implications when modeling short-format text, e.g. voice search/query LMs. Building LSTM $n$-gram LMs may be appealing for some practical situations: the state in a $n$-gram LM can be succinctly represented with $(n-1)*4$ bytes storing the identity of the words in the context and batches of $n$-gram contexts can be processed in parallel. On the downside, the $n$-gram context encoding computed by the LSTM is discarded, making the model more expensive than a regular recurrent LSTM LM.
A voltage quality improvement solution using step dynamic voltage regulator (2002)

The quality of power supply is largely synonymous with voltage quality. Momentary voltage dips and fluctuations are some of the common power quality disturbances in the electrical supply networks. The effects of these disturbances transcend beyond just annoyances for the utility customers but may cause industrial-process interruptions which can incur significant financial costs. Industries affected include plants with critical processes like semiconductor manufacturing. Although distribution transformers are generally equipped with multiple taps for regulating the output voltage, the response of the conventional mechanical tap-changers is not fast enough to compensate for fast voltage variations on a millisecond time scale. This project proposes three designs of cost effective step dynamic voltage regulator (S-DVR) as forms of series compensation to compensate voltage dips and swells within half a cycle of mains frequency for any critical load. They are namely, S-DVR6, S-DVR8 and S-DVR12. The S-DVRs can counteract a wide variety of voltage fluctuations, with no limit on the duration. The S-DVR12 is simulated in a 230/66 kV network to highlight its effectiveness in overcoming power quality disturbances.
Polarization-induced fading in fiber-optic sensor arrays (1995)

The statistics of polarization-induced visibility fading is studied for fiber-optic interferometric (Michelson or Mach-Zehnder) sensor arrays made of either regular single-mode fibers or polarization-maintaining fibers. Performance is measured in terms of the probability to observe visibilities, all of which exceed a given value, for all members of the array. Very poor performance is obtained for arrays made of nonpolarization maintaining fibers, unless the input state of polarization is dynamically controlled to optimize the visibility of the worst sensor of the array. While the use of the more costly polarization-maintaining fibers could, in principle, solve this polarization-related fading problem, finite extinction ratios of couplers and splices make the performance of such arrays comparable to that of nonpolarization maintaining arrays with optimally controlled input-polarization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>