gebhart/patrepeval huggingface dataset:
A new cytotoxin from <i>Bacillus cereus</i> that may cause necrotic enteritis (2000)

A cytotoxin (CytK) has been isolated from a Bacillus cereus strain that caused a severe food poisoning outbreak killing three people. A protein of 34 kDa was highly cytotoxic, and the addition of other secreted proteins gave no synergistic effect. CytK was also necrotic and haemolytic. No known B. cereus enterotoxins were produced by this strain. A DNA sequence from 1.8 kb upstream to 0.2 kb downstream of the toxin gene was sequenced. The deduced amino acid sequence of the toxin showed similarity to Staphylococcus aureus leucocidins, gamma-haemolysin and alpha-haemolysin, Clostridium perfringens beta-toxin and B. cereus haemolysin II, all belonging to a family of beta-barrel channel-forming toxins. There was no sequence similarity between CytK and enterotoxins of B. cereus. The upstream sequence contained a partial sequence of a putative histidine kinase gene. A recognition site for PlcR, which regulates the transcription of enterotoxins HBL and Nhe of B. cereus, was found in the promoter region of the toxin. This new cytotoxin may be responsible for a disease that is similar to, although not as severe as, the necrotic enteritis caused by the beta-toxin of C. perfringens type C.
Electronic Circuits for High Bit Rate Digital Fiber Optic Communication Systems (1978)

This paper describes electronic components for digital fiber optic transmitters and receivers with bit rates from several hundred Mbits/s up into the Gbits/s range. In particular, drivers and multiplexers suitable for direct laser modulation were developed for use in the transmitter units. A laser light output control circuit for independent stabilization of the minimum and peak to peak laser light output levels is described. A demultiplexer and clock regenerator circuit was developed for optical receivers. All high speed components were realized in thin film hybrid integrated technology using silicon bipolar transistors, Schottky diodes and step recovery diodes.
Resistance to <scp>d</scp> -Cycloserine in the Tubercle Bacilli: Mutation Rate and Transport of Alanine in Parental Cells and Drug-Resistant Mutants (1971)

A single transport system was found to accumulate l- and d-alanine, glycine and d-serine in Mycobacterium tuberculosis. The results of inhibition experiments suggested that the antibiotics d-cycloserine and O-carbamyl-d-serine were also transported by the alanine-glycine-d-serine system. A d-cycloserine-resistant permease-competent (d-CS(r)/perm(+)) mutant and a d-cycloserine-resistant permease-defective (d-CS(r)/perm(-)) mutant were isolated. The d-CS(r)/perm(-) mutant was not found to be more resistant to the drug than was the d-CS(r)/perm(+) mutant. The data were consistent with the conclusion that resistance to d-cycloserine in the tubercle bacilli is primarily due to mutations in the gene(s) controlling the enzyme d-alanyl-d-alanine synthetase. The mutation rate was calculated to be about 10(-10) mutations per bacterium per generation.
Fractionation and Characterization of Mitogenic and Anti-Complementary Active Fractions from Kampo (Japanese Herbal) Medicine “Juzen-Taiho-To”<sup>1</sup> (1990)

"Juzen-Taiho-To" (TJ-48), which is a kampo (Japanese herbal) medicine prepared by decocting a prescription of ten kinds of herbs, has several immunostimulating activities. In order to characterize the active substances for anti-complementary and mitogenic activities, TJ-48 was fractionated. Anti-complementary activity was observed in the water- and methanol-insoluble fraction (F-2) and the crude polysaccharide fraction (F-5), whereas mitogenic activity was only found in F-5. However, other low molecular mass fractions did not show both activities. Methylation analysis indicated that F-2 mainly contained amylopectin-like polysaccharides. Both Pronase digestion and periodate oxidation decreased the anti-complementary activity of F-2, and the beta-amylase-resistant fraction of F-2 still retained the potent anti-complementary activity. When F-5, which has the most potent of both activities, was further fractionated, only the major acidic polysaccharide fraction, F-5-2, showed potent mitogenic activity. Endo-alpha-(1----4)-polygalacturonase digestion showed that F-5-2 mainly contained pectic polysaccharides, and the endo-polygalacturonase treatment of F-5-2 reduced the mitogenic activity but not the anti-complementary activity. F-2 and F-5 each activated the complement system by a different mode of action.
Bi-directional Translation of Relational Data into Virtual RDF Stores (2010)

A vast majority of the world's valuable data currently exists in relational databases and other legacy storage systems. In order for Semantic Web applications to access such legacy data without replication or synchronization of the same, the gap between the two needs to be bridged. Several efforts exist that publish relational data as Resource Description Framework (RDF) triples, however almost all current work in this arena is uni-directional, presenting the existing and new data from an underlying relational database into a corresponding virtual RDF store in a read-only manner. This paper expands on previous relational-to-RDF bridging work, by enabling the bridge to be bi-directional and allowing data updates specified as triples to be propagated back to the relational database as tuples. Algorithms to translate the triples to be updated/inserted/deleted into equivalent relational attributes/tuples whenever possible are presented. A widely embraced open-source tool called D2RQ is enhanced with these algorithms to serve as evidence of the bi-directionality of our translation process.
Silicon micro-ring resonator based 16-QAM modulator for WDM transmission systems (2013)

In this paper a silicon micro-ring resonator assisted 16-QAM modulator suitable for WDM application has been proposed. We have demonstrated successful operation of the proposed 16-QAM modulator operating at 10 Gbps and 20 Gbps bit-rate per channel for a three channel WDM system. The performance of the modulator for different channel separation has also been investigated using detailed numerical simulations.
Ring C conformation of 6.beta.-naltrexol and 6.alpha.-naltrexol. Evidence from proton and carbon-13 nuclear magnetic resonance (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing C conformation of 6.beta.-naltrexol and 6.alpha.-naltrexol. Evidence from proton and carbon-13 nuclear magnetic resonanceGeorge A. Brine, Doriswamy Prakash, Carolyn King Hart, Dennis J. Kotchmar, Charles G. Moreland, and Frank I. CarrollCite this: J. Org. Chem. 1976, 41, 21, 3445–3448Publication Date (Print):October 1, 1976Publication History Published online1 May 2002Published inissue 1 October 1976https://pubs.acs.org/doi/10.1021/jo00883a027https://doi.org/10.1021/jo00883a027research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gamma dosimetry with Al<sub>2</sub>O<sub>3</sub> thermoluminescent phosphor (1976)

Preparation of thermoluminscence (TL) dosimetric grade A12O3 powder and pellets five times more sensitive than TLD-100 is described. Glow peaks at 50, 125, 250, 325, 475 and 625 degrees C with emission in the blue region have been observed; Si and Ti have been identified as the impurities responsible for TL in this phosphor. Studies of the TL growth rate with exposure showed that the 250 degrees c peak grew linearly up to 400 R and then at a supralinear rate of (exposure). The growth of the 475 degrees c peak was almost linear at a rate of (exposure) 1-05, while that for the 625 degrees C peak was sublinear at (exposure) 0-85. The 250 and 475 degrees peaks together show a linear response up to 40 000 R. The phosphor had no light sensitivity and is very well suited for gamma dosimetry as pellets or powder. Studies of sensitization and supralinearity, with sensitizing exposure, sensitizing anneal temperature and test gamma and alpha exposures are reported. Initially filled 625 degrees C TL related traps were found to be essential for sensitizaiton. Supralinearity and sensitization in Al2O3 phosphor could be consistently explained by the deep trap model.
Performance comparison of Protein A affinity‐chromatography sorbents for purifying recombinant monoclonal antibodies (1999)

We describe the performance characteristics of five Protein A affinity-chromatography sorbents (Sepharose Fast Flow, Poros 50, Poros LP, Prosep and Streamline) for purifying a recombinant humanized monoclonal antibody from clarified Chinese hamster ovary cell culture fluid. We measured the dynamic capacity at varying flow rates, maximum capacity, pressure drop and production rate. For purified antibody, we measured yield and purity (by SDS/PAGE, the amount of DNA, the amount of host-cell proteins and the amount of Protein A). We found that, whereas all sorbents provided significant and essentially equivalent antibody purification, there were differences in capacity and pressure drop, which affected the production rate and had implications for process applications.
Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits. (2002)

These results demonstrate that INS37217 enhances subretinal fluid reabsorption in experimental retinal detachment in rabbits and support the development of INS37217 for stimulating subretinal fluid reabsorption in conditions that result in retinal detachment or retinal edema.
Short‐Term Immobilization of Fertilizer Nitrogen at the Surface of No‐Till and Plowed Soils (1984)

Abstract Immobilization of (NH 4 ) 2 SO 4 in no‐till and conventionally tilled soils was monitored after application of 15 N enriched material to the surface of 20‐cm diameter plots on three soil types. Soils were collected periodically up to 35 d and 15 N in organic and inorganic fractions was measured. On all three soils there was more immobilization in no‐till. After 35 d, the percentage of fertilizer applied that was immobilized was 21 and 11 on Maury silt loam, 13 and 6 on Tilsit silt loam, and 24 and 15 on Cavode silt loam for no‐till and conventional tillage, respectively. There were no consistent trends or statistically significant differences between tillage treatments with regard to total N recovery (organic plus inorganic). The increased potential for immobilization of N at the surface of no‐till soils may significantly reduce crop recovery of fertilizer N.
A VISI Smart Sensor For Fast Range Imaging (2005)

VLSI technology makes possible a powerful new sensing methodology--the smart sensor. In a smart sensor, transducers are integrated with processing circuitry so that desired information can be intelligently extracted at the point of sensing. Physical limitations force traditional systems to artificially partition sensing and processing functions. By eliminating such partitioning, VLSI smart sensing adds a new dimension to the design of both sensors and sensing algorithms.
In this research, a high-performance VLSI range-image sensor has been built using the smart sensing methodology. This sensor measures range via light-stripe triangulation, a mature technology widely used in robotic systems. VLSI-based smart sensing made practical a cell-parallel implementation of the light-stripe method. Experiments with the cell-parallel sensor show that its performance is substantially better than that of traditional light-stripe systems. Range image acquisition time is decreased by two orders of magnitude. Furthermore, the range measurement process is qualitatively different, providing more robust and more accurate 3-D measurements. The success of the cell-parallel sensor can be attributed directly to the use of smart sensing and convincingly demonstrates the power of the technique.
One of the most distinguishing features of this work is that it is not just a re-implementation of established algorithms using VLSI. Rather, this thesis demonstrates that intelligent data acquisition makes possible new approaches to sensing that can significantly improve sensor performance.
Semantic prioritization of novel causative genomic variants (2017)

Discriminating the causative disease variant(s) for individuals with inherited or de novo mutations presents one of the main challenges faced by the clinical genetics community today. Computational approaches for variant prioritization include machine learning methods utilizing a large number of features, including molecular information, interaction networks, or phenotypes. Here, we demonstrate the PhenomeNET Variant Predictor (PVP) system that exploits semantic technologies and automated reasoning over genotype-phenotype relations to filter and prioritize variants in whole exome and whole genome sequencing datasets. We demonstrate the performance of PVP in identifying causative variants on a large number of synthetic whole exome and whole genome sequences, covering a wide range of diseases and syndromes. In a retrospective study, we further illustrate the application of PVP for the interpretation of whole exome sequencing data in patients suffering from congenital hypothyroidism. We find that PVP accurately identifies causative variants in whole exome and whole genome sequencing datasets and provides a powerful resource for the discovery of causal variants.
Performance of eleventh district banks in 1989: progress but not profits (1990)

Commercial banks in the Eleventh Federal Reserve District reduced their losses substantially in 1989 but still collectively reported a loss for the year. The improvement primarily resulted from increases in fee income. In addition, Eleventh District banks reduced their nonperforming loans and the costs associated with these loans. Despite the improvement, District banks still have relatively large holdings of nonperforming loans and repossessed real estate. ; Balance sheets of Eleventh District banks show the effects of correcting the problems of low-quality assets. Charging off nonperforming loans reduced capital at District banks. In response to reduced capital, banks contracted their lending activity and invested in liquid assets. Asset growth has been very weak, and this growth resulted primarily from banks acquiring failed savings and loan associations.
“Roger that!” — The Value of Adding Social Feedback in Audio-Mediated Communications (2013)

Losing track of who is in a conversation, and what is being said, is always a problem especially on audio-only conference calls. This paper investigates how domain-independent social feedback can support such interactions, and improve communication, through the use of audio cues. In particular, we show how an agent can improve people’s ability to accurately identify and distinguish between speakers, reassure users about the presence of other collaborators on the line, and announce events like entry & exit with minimum impact on users cognitive ability.
Oxidation of gold by ultraviolet light and ozone at 25 °C (1995)

Gold surfaces have been found to be hydrophilic only after exhaustive preparation and with the ultimate care in sample preparation and treatment. The use of a combination of ultraviolet (UV) light and ozone has been described as a viable method of producing a clean, hydrophilic, gold surface. We have found that gold surfaces, which have been either stored in the laboratory after vacuum deposition or purchased as high purity standards, are oxidized by a combination of UV light and ozone generated from a mercury lamp. The samples were characterized with x-ray photoelectron spectroscopy (XPS) and ion scattering spectroscopy (ISS) prior to and after exposure to UV/ozone in a stainless steel box in laboratory air. After the cleaning process gold surfaces were found by XPS to contain less carbon and to be enriched in oxygen. The O 1s on the cleaned surface, which was not present on the untreated surface, consisted of two peaks that are attributed to gold oxide and hydroxyl. The oxide layer was found to be 17±4 Å thick by variable angle XPS depth profiling with an initial stoichiometry of Au2O3. The oxide was found to be stable to extended exposure to UHV and water and ethanol rinses. ISS compositional depth profiles confirmed the oxide layer thickness and that the hydrated surface layer is removed in the initial sputtering of the oxidized gold. Implications of these results related to the mechanism of self-assembly of thiols on gold are discussed.
Mathematical models of energy homeostasis (2008)

Diabetes and obesity present a mounting global challenge. Clinicians are increasingly turning to mechanism-based mathematical models for a quantitative definition of physiological defects such as insulin resistance, glucose intolerance and elevated obesity set points, and for predictions of the likely outcomes of therapeutic interventions. However, a very large range of such models is available, making a judicious choice difficult. To better inform this choice, here we present the most important models published to date in a uniform format, discussing similarities and differences in terms of the decisions faced by modellers. We review models for glucostasis, based on the glucose-insulin feedback control loop, and consider extensions to long-term energy balance, dislipidaemia and obesity.
ChemInform Abstract: Dynamic Combinatorial Chemistry (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Transient Interactions between Collagen-tailed Acetylcholinesterase and Sulfated Proteoglycans Prior to Immobilization on the Extracellular Matrix (1996)

Heparin is capable of solubilizing a subset of collagen-tailed (A12) acetylcholinesterase (AChE) molecules from skeletal basal lamina (Rossi, S. G., and Rotundo, R. L. (1993) J. Biol. Chem. 268, 19152-19159). In the present study, we used tissue-cultured quail myotubes to show that, like adult fibers, neither heparin- nor high salt-containing buffers detached AChE molecules from cell-surface clusters. Prelabeling clustered AChE molecules with anti-AchE monoclonal antibody 1A2 followed by incubation in heparin-containing medium showed that there was no reduction in the number or size of preexisting AChE clusters. In contrast, incubation of myotubes with culture medium containing heparin for up to 4 days reversibly blocked the accumulation of new cell-surface AChE molecules without affecting the rate of AChE synthesis or assembly. Newly synthesized A12 AChE becomes tightly attached to the extracellular matrix following externalization. However, in the presence of heparin, blocking the initial interactions between A12 AChE and the extracellular matrix results in release of AChE into the medium with a t1/2 of approximately 3 h. Together, these results suggest that once A12 AChE is localized on the cell surface, initially attached via electrostatic interactions, additional factors or events are responsible for its selective and more permanent retention on the basal lamina.
A Survey on Security Threats for Cloud Computing (2012)

Cloud Computing provides an efficient and flexible way for services to meet escalating business needs. Cloudshared infrastructure and associated services make it cost effective alternative to traditional approaches. However, they may also introduce security breaches and privacy issues. As more cloud based applications keep evolving, the associated security threats are also growing. Many research works on cloud security exist in partial forms of either specifically on cloud issues or virtualization-related security issues. In this paper, an attempt has been made to consolidate the various security threats in a classified manner and to illustrate how cloud and virtualization vulnerabilities affect the different cloud service models.
Inhibition of host protein synthesis by vaccinia virus: fate of cell mRNA and synthesis of small poly (A)-rich polyribonucleotides in the presence of actinomycin D (1975)

Purified vaccinia virus rapidly inhibited HeLa cell protein synthesis in the presence of actinomycin D. Under these conditions host polyribosomes were extensively degraded but the mRNA was stable as indicated by a greater than 90% recovery of prelabeled polyadenylylated RNA. Although actinomycin D prevented the synthesis of host mRNA and poly(A) in uninfected cells, incorporation of adenosine into poly(A) was inhibited by less than 50% in infected cells. Further analysis indicated that there was little or no normal size viral mRNA but that a unique class of small poly(A)-rich RNA was made in the presence of actinomycin D. From measurements of the RNase resistance and base composition of the RNA, approximately 40% of the nucleotide sequence was estimated to be poly(A). The poly(A)-rich RNA was found associated with small polyribosomes and monoribosomes that were inactive in protein synthesis. It was suggested that the poly(A) segment of the RNA is formed by the poly(A) polymerase previously found in vaccinia virus cores and that the inactive RNA, by competing with host mRNA, may contribute to the virus-mediated inhibition of host protein synthesis observed in the presence of actinomycin D.
Effect of intraocular lens optic design on posterior capsular opacification (1990)

Secondary capsular opacification is a common complication of extracapsular cataract extraction. We have done a retrospective study of 1,040 consecutive posterior chamber implants using four optic designs. The annual incidence of capsular opacification requiring capsulotomy was calculated to see if the optic design was a possible factor. The laser ridge and laser "peg" optics each had a cumulative capsulotomy rate of over 40.0% at three years and the convex-plano optic, over 40.0% at five years. Optics of plano-convex/biconvex designs had a cumulative capsulotomy rate of 5.0% at three years and 6.5% at five years. These results strongly suggest that capsular opacification is retarded when there is broad adhesion of the lens optic to the posterior capsule.
Improved efficiency, IP3-bandwidth and robustness of a microwave Darlington amplifier using 0.5/spl mu/m ED PHEMT and a new circuit topology (2005)

This paper reports on the first results of a self-biased e-mode PHEMT Darlington amplifier. The e-mode PHEMTs enable a FET Darlington implementation while a new Darlington active bias topology reduces bias variation over temperature and supply, and improves overall efficiency by reducing supply operation. A 3.3V-75mA amplifier achieves a BW of 0.1-14GHz, 12.3dB gain, NF of 3.5dB, IP3 and P1dB of 33.1dBm and 16dBm @ 2GHz, respectively. A 5V-75mA amplifier achieves a 0.1-10 GHz BW, 20.2 dB gain, NF of 2.9 dB, IP3 and P1dB of 34.2dBm and 21.8dBm @ 2 GHz, respectively. The new PHEMT Darlington amplifier design enables a factor of 2 better IP3-bandwidth product and lower voltage operation capability compared to InGaP-based Darlington amplifiers.
Polyethylene-Glycol-Ferrioxamine A New Magnetic Resonance Contrast Agent (1990)

SCHULTHESS, G. K. VON MD, PHD; DUEWELL, S. MD; JENNY, H-B. PHD; WÜTHRICH, R. MD; PETER, H. H. PHD Author Information