gebhart/patrepeval huggingface dataset:
Topography of nucleic acid helices in solution. XXVI. Specific interaction of peptides with nucleic acids (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTopography of nucleic acid helices in solution. XXVI. Specific interaction of peptides with nucleic acidsEdmond J. Gabbay, Karl Sanford, and C. Stuart BaxterCite this: Biochemistry 1972, 11, 18, 3429–3435Publication Date (Print):August 1, 1972Publication History Published online1 May 2002Published inissue 1 August 1972https://pubs.acs.org/doi/10.1021/bi00768a016https://doi.org/10.1021/bi00768a016research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SBVLC: Secure barcode-based visible light communication for smartphones (2014)

As an alternative to NFC technology, 2D barcodes have been increasingly used for security-sensitive applications including payments and personal identification. However, the security of barcode-based communication in mobile applications has not been systematically studied. Due to the visual nature, 2D barcodes are subject to eavesdropping when they are displayed on the screen of a smartphone. On the other hand, the fundamental design principles of 2D barcodes make it difficult to add security features. In this paper, we propose SBVLC - a secure system for barcode-based visible light communication (VLC) between smartphones. We formally analyze the security of SBVLC based on geometric models and propose physical security enhancement mechanisms for barcode communication by manipulating screen view angles and leveraging user-induced motions. We then develop two secure data exchange schemes. These schemes are useful in many security-sensitive mobile applications including private information sharing, secure device pairing, and mobile payment. SBVLC is evaluated through extensive experiments on both Android and iOS smartphones.
Comparative drug metabolism and disposition in minor species. (1988)

The disposition of fenbendazole (FBZ) was studied in vivo in cattle (steers), goats, chickens, ducks, turkeys and rabbits, and in vitro in hepatic enzyme preparations from cattle, sheep, goats, rabbits, rats, chickens, ducks, turkeys and catfish. The major excretory metabolite when FBZ was administered either iv or po (5 mg/kg) was p-hydroxyfenbendazole (FBZ-OH). The sulfoxide (FBZ-SO) and sulfone (FBZ-SO2) appeared in plasma but were recovered in only trace amounts in urine or feces, and the amine (FBZ-NH2) was a minor metabolite appearing only occasionally in plasma. The greatest species differences were seen among the avian species, and differences in metabolite excretion correlated well with the ability of the species to metabolize the drug (especially to FBZ-OH) in vitro. Other in vitro studies measured the rate of oxidative, hydrolytic, and conjugative (glucuronide, acetate, sulfate) pathways in liver preparations.
Acyl Transfer Activity of an Amidase from <i>Rhodococcus</i> sp. Strain R312: Formation of a Wide Range of Hydroxamic Acids (1998)

The enantioselective amidase from Rhodococcus sp. strain R312 was produced in Escherichia coli and was purified in one chromatographic step. This enzyme was shown to catalyze the acyl transfer reaction to hydroxylamine from a wide range of amides. The optimum working pH values were 7 with neutral amides and 8 with alpha-aminoamides. The reaction occurred according to a Ping Pong Bi Bi mechanism. The kinetic constants demonstrated that the presence of a hydrophobic moiety in the carbon side chain considerably decreased the Km(amide) values (e.g., Km(amide) = 0.1 mM for butyramide, isobutyramide, valeramide, pivalamide, hexanoamide, and benzamide). Moreover, very high turnover numbers (kcat) were obtained with linear aliphatic amides (e.g., kcat = 333 s-1 with hexanoamide), whereas branched-side-chain-, aromatic cycle- or heterocycle-containing amides were sterically hindered. Carboxylic acids, alpha-amino acids, and methyl esters were not acyl donors or were very bad acyl donors. Only amides and hydroxamic acids, both of which contained amide bonds, were determined to be efficient acyl donors. On the other hand, the highest affinities of the acyl-enzyme complexes for hydroxylamine were obtained with short, polar or unsaturated amides as acyl donors (e.g., KmNH2OH = 20, 25, and 5 mM for acetyl-, alanyl-, and acryloyl-enzyme complexes, respectively). No acyl acceptors except water and hydroxylamine were found. Finally, the purified amidase was shown to be L-enantioselective towards alpha-hydroxy- and alpha-aminoamides.
Pulsed Direct liquid Injection ALD of TiO2 Films Using Titanium Tetraisopropoxide Precursor (2013)

Abstract TiO 2 thin films are grown by pulsed direct liquid injection atomic layer deposition with rapid thermal heating using titanium tetraisopropoxide and water vapor as precursors. The ALD growth rate is constant in the saturation zone range 35-47 ms at the temperature deposition of 280 °C. The TiO 2 growth rate of 0.018 nm/cycle was achieved in a self-limited ALD mode. SEM and AFM analysis showed the as-deposited films have a smooth surface with a low roughness. XPS analysis exhibited the stoichiometry of TiO 2 in the homogenous depth composition.
CCR9 mediates PI3K/AKT‐dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9‐CCL25 interaction enhances the cytotoxic effects of etoposide (2010)

Despite recent advances in treatment and management of prostate cancer (PCa), it remains the second leading cause of cancer-related deaths among men in the US. Chemotherapy is one of the treatment alternatives for hormone refractory metastatic PCa. However, current chemotherapeutic regimens provide palliative benefit but relatively modest survival advantage primarily due to chemo-resistance and upregulated antiapoptotic machineries in PCa cells. Therefore, blocking the mechanisms responsible for suppression of apoptosis might improve current chemotherapeutic regimens. In this study, we show that CC chemokine receptor-9 (CCR9) and its natural ligand CCL25 interaction upregulates antiapoptotic proteins (i.e., PI3K, AKT, ERK1/2 and GSK-3beta) and downregulate activation of caspase-3 in PCa cells. Significant downregulation of these CCR9-mediated antiapoptotic proteins in the presence of a PI3K inhibitor (wortmannin), further suggests that the antiapoptotic action of CCR9 is primarily regulated through PI3K. Furthermore, the cytotoxic effect of etoposide was significantly inhibited in the presence of CCL25, and this inhibitory effect of CCL25 was abrogated when CCR9-CCL25 interaction was blocked using anti-CCR9 monoclonal antibodies. In conformation to these in vitro studies, significant reduction in tumor burden was found in mice receiving CCL25 neutralizing antibodies and etoposide together as compared to both as a single agent. These results suggest that the CCR9-CCL25 axis mediates PI3K/AKT-dependent antiapoptotic signals in PCa cells and could be a possible reason for low apoptosis and modest chemotherapeutic response. Therefore, targeting CCR9-CCL25 axis with cytotoxic agents may provide better therapeutic outcomes than using cytotoxic agents alone.
Ultrafast superconducting single-photon detectors for infrared wavelength quantum communications (2003)

We have developed a new class of superconducting single-photon detectors (SSPDs) for ultrafast counting of infrared (IR) photons for secure quantum communications. The devices are operated on the quantum detection mechanism, based on the photon-induced hotspot formation and subsequent appearance of a transient resistive barrier across an ultrathin and submicron-wide superconducting stripe. The detectors are fabricated from 3.5-nm-thick NbN films and they operate at 4.2 K inside a closed-cycle refrigerator or liquid helium cryostat. Various continuous and pulsed laser sources have been used in our experiments, enabling us to determine the detector experimental quantum efficiency (QE) in the photon-counting mode, response time, time jitter, and dark counts. Our 3.5-nm-thick SSPDs reached QE above 15% for visible light photons and 5% at 1.3 - 1.5 μm infrared range. The measured real-time counting rate was above 2 GHz and was limited by the read-out electronics (intrinsic response time is <30 ps). The measured jitter was <18 ps, and the dark counting rate was <0.01 per second. The measured noise equivalent power (NEP) is 2 x 10<sup>-18</sup> W/Hz<sup>1/2</sup> at λ = 1.3 μm. In near-infrared range, in terms of the counting rate, jitter, dark counts, and overall sensitivity, the NbN SSPDs significantly outperform their semiconductor counterparts. An ultrafast quantum cryptography communication technology based on SSPDs is proposed and discussed.
A gcc-based Java implementation (2002)

While a major factor in Java's success is its use of portable byte codes, we believe it cannot become a mainstream programming language without mainstream implementation techniques, specifically an optimizing ahead-of-time compiler. This allows much better optimization and much faster application start-up times than with JIT (just-in-time) translators. Cygnus Solutions are writing a Java front-end for the GNU compiler compiler (gcc) to translate Java byte codes into machine code. This uses proved and widely-used technology. The meta-data representing a class at run-time are laid out by the compiler in static data memory, saving more start-up time. We use the GNU linker to link compiled class files into standard shared or static libraries. For the run-time environment, we are enhancing the existing Kaffe-free Java virtual memory to make it full-strength and to support linking with pre-compiled class libraries. We are enhancing the GNU debugger (gdb) to understand Java, which will provide a familiar and multi-language debugging environment.
Analysis of peptide metabolism by ruminal microorganisms (1989)

Methods were developed for the determination of oligoalanine and other short-chain peptides and peptide analogs in ruminal fluid by using reverse-phase high-pressure liquid chromatography. Chromatographic analysis of the breakdown of (Ala)3 and (Ala)4 in ruminal fluid in vitro revealed that the predominant mechanism of hydrolysis was a dipeptidyl peptidase-like activity. Hydrolysis proceeded from the N terminal of the peptide chain; N-acetyl-(Ala)3 was broken down at 11% of the rate of breakdown of (Ala)3 or (Ala)3-p-nitroanilide. (Ala)2-p-nitroanilide was hydrolyzed most rapidly of the arylamide substrates tested, but fluorogenic 4-methoxy-2-naphthylamide (MNA) compounds were more convenient and potentially more versatile substrates than p-nitroanilides. Gly-Arg-MNA was the most rapidly hydrolyzed dipeptidyl peptidase substrate, suggesting that ruminal peptidase activity was predominantly of a type I specificity.
Removal and recovery of cyanide and zinc from electroplating wastes by solvent extraction (1976)

The horrific nature of George Floyd's killing by a Minneapolis Police Department officer on May 25, 2020 sparked an enduring stretch of nationwide protests against police brutality and in support of the Black Lives Matter movement. During periods of crisis, anchor institutions may exert leadership by issuing public statements to communicate shared institutional values, enhance morale, and signal direction in the face of crisis. In our analysis of public statements issued by 56 leading U.S. medical schools, we found that nearly all identified George Floyd by name, and a majority noted the role of racism or acknowledged the Black community specifically. Fewer referenced the act resulting in Floyd's death or made explicit reference to the police. Far fewer explicitly used terms denoting active support, like "antiracism" or "Black Lives Matter." Only a minority of institutions made reference to the killing of George Floyd by the police, and most failed to address this country's targeted, historically engrained, and sustained oppression of Black people through white supremacy. Thus, there remain significant opportunities for U.S. medical schools to exert meaningful leadership in public health.
Oxidation as a Post-Translational Modification that Regulates Autophagy (2007)

The toxicity associated with accumulation of reactive oxygen species (ROS) has led to the evolution of various defense strategies to overcome oxidative stress, including autophagy. This pathway is involved in the removal and degradation of damaged mitochondria and oxidized proteins. At low levels, however, ROS act as signal transducers in various intracellular pathways. In a recent study we described the role of ROS as signaling molecules in starvation-induced autophagy. We showed that starvation stimulates formation of ROS, specifically H(2)O(2), in the mitochondria. Furthermore, we identified the cysteine protease HsAtg4 as a direct target for oxidation by H(2)O(2), and specified a cysteine residue located near the HsAtg4 catalytic site as critical for this regulation. Here we focus on Atg4, the target of regulation, and discuss possible mechanisms for the regulation of this enzyme in the autophagic process.
The Complement System in Schizophrenia (2008)

Several lines of evidence suggest that immunological factors contribute to schizophrenia. Since 1989, the role of complement, a major effector of innate immunity and an adjuvant of adaptive immunity, has been explored in schizophrenia. Increased activity of C1, C3, C4 complement components in schizophrenia has been reported by two or more groups. Two studies on different subject cohorts showed increased MBL-MASP-2 activity in patients versus controls. More then one report indicated a significant high frequency of FB*F allotype and low prevalence of the FS phenotype of complement factor B in schizophrenia. From the data reported, it is likely that the disorder is accompanied by alterations of the complement classical and lectin pathways, which undergo dynamic changes, depending on the illness course and the state of neuro-immune crosstalk. Recent findings, implicating complement in neurogenesis, synapse remodeling and pruning during brain development, suggest a reexamination of the potential role of complement in neurodevelopmental processes contributing to schizophrenia susceptibility. It is plausible that the multicomponent complement system has more than one dimensional association with schizophrenia susceptibility, pathopsychology and illness course, understanding of which will bring a new perspective for possible immunomodulation and immunocorrection of the disease.
Inexpensive electrochemical synthesis of nickel iron sulphides on nickel foam: super active and ultra-durable electrocatalysts for alkaline electrolyte membrane water electrolysis (2016)

The inexpensive fabrication of nano-honeycomb structured nickel iron sulphides on a nickel foam current collector is described and used as both anode and cathode in the alkaline membrane water electrolysis.
Hormone-sensitive Lipase Is Structurally Related to Acetylcholinesterase, Bile Salt-stimulated Lipase, and Several Fungal Lipases (1996)

Hormone-sensitive lipase is the key enzyme in the mobilization of fatty acids from adipose tissue, thereby playing a crucial role in the overall energy homeostasis in mammals. Its activity is stimulated by catecholamines through cAMP-dependent phosphorylation of a single serine, a process that is prevented by insulin. This regulatory property is unique to this enzyme among all known lipases and has been acquired during evolution through insertion of a regulatory module into an ancestral lipase. Sequence alignments have failed to detect significant homology between hormone-sensitive lipase and the rest of the mammalian lipases and esterases, to which this enzyme is only very distantly related. In the present work, we report the finding of a remarkable secondary structure homology between hormone-sensitive lipase and the enzymes from a superfamily of esterases and lipases that includes acetylcholinesterase, bile salt-stimulated lipase, and several fungal lipases. This finding, based on the identification of the secondary structure elements in the hormone-sensitive lipase sequence, has allowed us to construct a three-dimensional model for the catalytic domain of hormone-sensitive lipase. The model reveals the topological organization, predicts the components of the catalytic triad, suggests a three-dimensional localization of the regulatory module, and provides a valuable tool for the future study of structural and functional aspects of this metabolically important enzyme.
A new electrically controllable diffraction grating using polarization reflection (1976)

An electrically controllable diffraction (ECD) grating using a polarization reflection from an electro-optic (EO) material is proposed and investigated in the experiments. The fundamental characteristics of this ECD grating are given experimentally for a He-Ne 0.63-μm laser. The grating used consists of a PLZT ceramic with ten pairs of interdigital electrodes having a period of 400 μm. Applying the electric field to the electrodes, the diffraction pattern can be changed due to the deviation of the reflectance of the EO material. Near the zeroth-order diffraction peak the maximum modulation degree of 33% was obtained with an applied peak voltage of 100 V at an incident angle 60°.
Highly enantioselective asymmetric Darzens reactions with a phase transfer catalyst (2011)

A class of easily accessible and readily tunable chiral phase transfer catalysts based on 6'-OH cinchonium salts was found to efficiently catalyze an unprecedented highly enantioselective Darzens reaction of α-chloro ketones and aldehydes, which directly produces optically active chiral epoxides from readily available carbonyl compounds.
A scalable micro wireless interconnect structure for CMPs (2009)

This paper describes an unconventional way to apply wireless networking in emerging technologies. It makes the case for using a two-tier hybrid wireless/wired architecture to interconnect hundreds to thousands of cores in chip multiprocessors (CMPs), where current interconnect technologies face severe scaling limitations in excessive latency, long wiring, and complex layout. We propose a recursive wireless interconnect structure called the WCube that features a single transmit antenna and multiple receive antennas at each micro wireless router and offers scalable performance in terms of latency and connectivity. We show the feasibility to build miniature on-chip antennas, and simple transmitters and receivers that operate at 100-500 GHz sub-terahertz frequency bands. We also devise new two-tier wormhole based routing algorithms that are deadlock free and ensure a minimum-latency route on a 1000-core on-chip interconnect network. Our simulations show that our protocol suite can reduce the observed latency by 20% to 45%, and consumes power that is comparable to or less than current 2-D wired mesh designs.
Purification and Characterization of an Inhibitor of Calcium-Activated Neutral Protease from Rabbit Skeletal Muscle: Purification of 50,000-Dalton Inhibitor (1984)

An endogenous inhibitor of calcium-activated neutral protease (CANP), which was isolated from rabbit skeletal muscle under mild conditions, comprised high- and low-molecular-weight components. The latter (LMW-inhibitor; Mr=50,000) was purified to homogeneity by means of chromatography on DEAE-cellulose and phenyl-Sepharose CL-4B and chromatofocusing. The purified inhibitor is a protein composed of two polypeptide chains with molecular weights of 26,000 and 24,000 daltons. It contains large amounts of glutamic acid, alanine, and serine, and small amounts of aromatic amino acids. It was specific for CANPs having low (m-type) and high (mu-type) Ca2+-sensitivity, had no effect on any other protease examined (trypsin, alpha-chymotrypsin, bromelain, ficin, papain, thermolysin, etc.), and inhibited rabbit mCANP more effectively than rabbit muCANP or chicken mCANP. It was demonstrated that the inhibition is due to the formation of a stoichiometric complex between two molecules of rabbit mCANP and one inhibitor molecule.
Photodissociation dynamics of the N3 radical (1993)

The dissociation dynamics of the B̃ 2Σu+ state of N3 were investigated using fast radical beam photodissociation coupled with a new coincidence wedge-and-strip-anode particle detector. With this detector, detailed photofragment kinetic energy and angular distributions can be measured as a function of excitation energy. Calibration of the detector by studies of the predissociation of the O2 B 3Σu− state is discussed. Methods of extracting the center-of-mass kinetic energy and angular distributions are presented. The photodissociation results for N3 show that from the vibrationless level of the B̃ 2Σu+ state in N3, both spin-allowed [N3→N(2D)+N2(1Σg+)] and spin-forbidden [N3→N(4S)+N2(1Σg+)] dissociation processes occur. Bend excitation in the B̃ 2Σu+ state, however, enhances the spin-allowed dissociation process considerably. The kinetic energy distributions reveal partially resolved vibrational structure in the N2 fragment, and indicate substantial rotational excitation of the N2. This implies that bent geometries play a major role in the dissociation of the N3 B̃ state. Possible mechanisms for the spin-forbidden and spin-allowed dissociation channels are discussed.
A New Embedding Medium Available for Stereoscopic Observation of Semi-thin Sections under 200 kV Transmission Electron Microscope (1983)

Journal Article A New Embedding Medium Available for Stereoscopic Observation of Semi-thin Sections under 200 kV Transmission Electron Microscope Get access Hiroshi KUSHIDA, Hiroshi KUSHIDA *Electron Microscope Laboratory, Keio UniversityShinjuku-ku, Tokyo, 160 Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Tsuyuka KUSHIDA, Tsuyuka KUSHIDA **Department of Anatomy, Tokyo Women's Medical CollegeShinjuku-ku, Tokyo, 162 Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Katsuhisa YONEHARA, Katsuhisa YONEHARA ***Naka Works, Hitachi, Ltd.Katsuta, Ibaraki, 312 Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Eiko NAKAZAWA Eiko NAKAZAWA ***Naka Works, Hitachi, Ltd.Katsuta, Ibaraki, 312 Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Electron Microscopy, Volume 32, Issue 1, 1983, Pages 61–65, https://doi.org/10.1093/oxfordjournals.jmicro.a050397 Published: 01 January 1983 Article history Received: 28 October 1982 Published: 01 January 1983 Accepted: 16 February 1983