gebhart/patrepeval huggingface dataset:
The Major Studies on Vincent de Paul (1985)

The real Vincent de Paul, versus the legendary one, was not known for several centuries because his communities restricted his writings to themselves. This article categorizes and critiques the major works on him. It begins with the four institutional biographies from before the twentieth century by Louis Abelly, Pierre Collet, Michel-Ulysse Maynard, and Louis-Victor-Emile Bougaud. Twentieth century works are then evaluated, starting with those of Pierre Coste. Historical studies of the Church and spirituality during and after Vincent’s time place him in social, political, and ecclesial context. Other efforts examine how his works and spirituality may be applied to contemporary social problems. Three authors, Henri Bremond, Jean Calvet, and Andre Dodin, approach Vincent from a historical-spiritual perspective; two, Igino Giordani and Jose-Maria Ibanez-Burgos, have a historical-social focus.
A novel mechanism of sulfur transfer catalyzed by<i>O</i>-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of<i>Wolinella succinogenes</i> (2011)

O-Acetylhomoserine sulfhydrylase (OAHS) is a pyridoxal 5'-phosphate (PLP) dependent sulfide-utilizing enzyme in the L-cysteine and L-methionine biosynthetic pathways of various enteric bacteria and fungi. OAHS catalyzes the conversion of O-acetylhomoserine to homocysteine using sulfide in a process known as direct sulfhydrylation. However, the source of the sulfur has not been identified and no structures of OAHS have been reported in the literature. Here, the crystal structure of Wolinella succinogenes OAHS (MetY) determined at 2.2 Å resolution is reported. MetY crystallized in space group C2 with two monomers in the asymmetric unit. Size-exclusion chromatography, dynamic light scattering and crystal packing indicate that the biological unit is a tetramer in solution. This is further supported by the crystal structure, in which a tetramer is formed using a combination of noncrystallographic and crystallographic twofold axes. A search for structurally homologous proteins revealed that MetY has the same fold as cystathionine γ-lyase and methionine γ-lyase. The active sites of these enzymes, which are also PLP-dependent, share a high degree of structural similarity, suggesting that MetY belongs to the γ-elimination subclass of the Cys/Met metabolism PLP-dependent family of enzymes. The structure of MetY, together with biochemical data, provides insight into the mechanism of sulfur transfer to a small molecule via a protein thiocarboxylate intermediate.
The viable but nonculturable state in bacteria. (2005)

It had long been assumed that a bacterial cell was dead when it was no longer able to grow on routine culture media. We now know that this assumption is simplistic, and that there are many situations where a cell loses culturability but remains viable and potentially able to regrow. This mini-review defines what the "viable but nonculturable" (VBNC) state is, and illustrates the methods that can be used to show that a bacterial cell is in this physiological state. The diverse environmental factors which induce this state, and the variety of bacteria which have been shown to enter into the VBNC state, are listed. In recent years, a great amount of research has revealed what occurs in cells as they enter and exist in this state, and these studies are also detailed. The ability of cells to resuscitate from the VBNC state and return to an actively metabolizing and culturable form is described, as well as the ability of these cells to retain virulence. Finally, the question of why cells become nonculturable is addressed. It is hoped that this mini-review will encourage researchers to consider this survival state in their studies as an alternative to the conclusion that a lack of culturability indicates the cells they are examining are dead.
Highly Efficient <i>N</i>‐Monomethylation of Primary Aryl Amines (2009)

Abstract A highly efficient method for specific synthesis of N ‐monomethylarylamines is presented. Anilines were treated with acetic anhydride and triethylamine in dry CH 2 Cl 2 to give the corresponding acetamides. The subsequent N ‐monomethylation of acetyl aryl amines with methyl iodide and NaH in THF introduced methyl group. Acid hydrolysis of the N ‐methyl acetanilides in ethylene glycol generated the corresponding N ‐methyl‐ N ‐aryl amines in high yields. This method was also used to synthesize ( E )‐2‐bromo‐5‐(4‐methylaminostyryl)pyridine that may be useful as an amyloid imaging agent for Alzheimer's disease.
Computer Application in Appliance Testing (1975)

The system developed for component testing at an appliance manufacturing facility is described. The complete installation consists of minicomputers that control several test stands and report the test results to a central quality assurance station. The various system components are 1) a disk-based central computer quality assurance station, 2) three computerized test stands for simultaneous testing of 48 ``infinite switches'' used in electric range surface heater control, 3) air-fluidized aluminum oxide temperature baths, and 4) a snap-disk thermostat test stand, equipped with its own minicomputer and communications capability with the central station.
Query execution strategies for missing data in distributed heterogeneous object databases (2002)

The problem of missing data arises in the distributed heterogeneous object databases because of the missing attribute conflict and the existence of null values. A set of algorithms are provided in this paper for query processing when the predicates in global queries involve missing data. For providing more informative answers to the users, the maybe results due to missing data are presented in addition to the certain results. One algorithm is designed based on the centralized approach in which the data are sent to the same site for integration and then processing. On the other hand, for reducing the response time, the localized approaches evaluate the predicates in different component databases in parallel. The proposed algorithms are compared and discussed by the simulation result on the total execution time and response time.
Effective Strategies for Teaching Fluency. (1991)

With the growing number of scientific publications, practitioners can use scientific knowledge synthesis, including Clinical Practice Guidelines (CPG). The practical use of a CPG implies considering the context, that is the local healthcare system and the patient. Thus, the CPG can never replace the expertise of the practitioner! Diabetes is a wide public health issue and the canton of Vaud established the cantonal Diabetes Program (cDP), to optimize the care of diabetic patients. The cDP has many projects including the adaptation of reliable CPG to local needs. We present the pros and cons of the CPG in the cDP and the methods to adapt it to the regional healthcare context, and also at an individual level.
BSN-Care: A Secure IoT-Based Modern Healthcare System Using Body Sensor Network (2015)

Advances in information and communication technologies have led to the emergence of Internet of Things (IoT). In the modern health care environment, the usage of IoT technologies brings convenience of physicians and patients, since they are applied to various medical areas (such as real-time monitoring, patient information management, and healthcare management). The body sensor network (BSN) technology is one of the core technologies of IoT developments in healthcare system, where a patient can be monitored using a collection of tiny-powered and lightweight wireless sensor nodes. However, the development of this new technology in healthcare applications without considering security makes patient privacy vulnerable. In this paper, at first, we highlight the major security requirements in BSN-based modern healthcare system. Subsequently, we propose a secure IoT-based healthcare system using BSN, called BSN-Care, which can efficiently accomplish those requirements.
Exploiting user models and context-awareness to support personal daily activities (2001)

In experiments on HepG2 cells, we studied the effect of the original domestic neurotropic drugs omberacetam, fabomotizole, and ethylmethylhydroxypyridine succinate (EMHPS) (1-500 μM) on the activity and content of organic anion transporting polypeptides OATP1B1 and OATP1B3. It was shown that omberacetam (500 μM) increased the content of OATP1B1 and OATP1B3, fabomotizole did not affect the level of both transporters, and EMHPS (500 μM) increased the content of OATP1B1 compared to the control and did not affect the level of OATP1B3. The tested substances also reduced the OATP1B1/OATP1B3 ratio, as evidenced by a decrease in the penetration of atorvastatin, a substrate of the transporters, into HepG2 cells in the presence of omberacetam (100-500 μM), fabomotizole (500 μM), and EMHPS (10-500 μM). Evaluation of clinical significance of the obtained results, according to the FDA approach based on the calculation of the C<sub>max</sub>/IC<sub>50</sub> ratio, showed that the effect of the tested substances on OATP1B1/OATP1B3 is clinically insignificant.
The Tricyclic Antidepressant Desipramine Causes Proteolytic Degradation of Lysosomal Sphingomyelinase in Human Fibroblasts (1994)

The effect of the tricyclic antidepressant desipramine on the processing of lysosomal sphingomyelinase (EC 3.1.4.12) was investigated by pulse-chase studies on [35S]methionine labeled cultured human skin fibroblasts. Desipramine induced rapid intracellular degradation of mature acid sphingomyelinase when added to the cells in the micromolar range, concomitantly abolishing the enzyme activity. Pulse chase labeling revealed the disappearance of mature enzyme forms when fibroblasts were treated with 25 microM desipramine. Incubation of cells with 25 microM leupeptin, an inhibitor of thiol proteases, 24 h prior to desipramine intoxication prevented this drug-induced effect. From these results we conclude that desipramine and possibly also similarly acting tricyclic antidepressants induce proteolytic degradation of acid sphingomyelinase.
Velocity Profiles and Roughness Effects in Annular Pipes (1964)

Friction factors and velocity distributions have been measured for a fluid flowing past a rough surface, which formed the core of a rough-smooth annulus. Pressure drops along and velocity profiles across the annulus were measured for annular Reynolds numbers of up to 4 times 10 4 . A transformation suggested by Hall (1)† was then used to isolate the effects of the rough inner surface from those of the smooth outer surface. When the velocity profiles for the rough part of the annulus were plotted in universal form, with all radial dimensions reduced to an effective diameter form, the results agreed well with data for circular pipes. When the friction factor-Reynolds number relationships were compared with those of Nikuradse (2) in his experiments with sand-roughened pipes, it was seen that a close resemblance in the roughness type existed.
Fluorescence lidar multicolor imaging of vegetation (1994)

Multicolor imaging of vegetation fluorescence following laser excitation is reported for distances of 50 m. A mobile laser-radar system equipped with a Nd:YAG laser transmitter and a 40-cm-diameter telescope was utilized. The laser light was Raman shifted to 397 nm with pulse energies of ˜ 30 mJ. An image-intensified CCD camera with a specially designed split-mirror Cassegrainian telescope was utilized for the simultaneous recording of fluorescence images of leaves and branches in four different spectral bands. Additionally, fluorescence spectra at selected points within the detection area were measured with an image-intensified diode array system. Image processing permits extraction of information related to the physiological status of the vegetation and might prove useful in forest decline research.
Multicast FullHD H.264 Intra Video Encoder Architecture (2015)

High throughput demands have resulted in enormous increase in complexity of multicast video applications, which require multiple video encoders to simultaneously compress individual views. In this paper, we present an approach to encode independent videos using H.264 intra encoder on a single hardware platform, where the hardware resources are shared by independent encoders in a time-multiplexed manner. In addition to lowering the latency introduced by multicasting, we address the strong sequential data dependencies within the encoder. At 25 frames/s, 150 MHz prototype of the proposed encoder and multiple video capture/display on a mid-range field programmable gate array is also presented.
Biochemical Analysis of Recombinant Fungal Mutanases (2000)

Nucleotide sequence analysis shows that<i>Trichoderma harzianum</i> and <i>Penicillium purpurogenum</i> α1,3-glucanases (mutanases) have homologous primary structures (53% amino acid sequence identity), and are composed of two distinct domains: a NH<sub>2</sub>-terminal catalytic domain and a putative COOH<i>-</i>terminal polysaccharide-binding domain separated by a <i>O-</i>glycosylated Pro-Ser-Thr-rich linker peptide. Each mutanase was expressed in <i>Aspergillus oryzae</i> host under the transcriptional control of a strong α-amylase gene promoter. The purified recombinant mutanases show a pH optimum in the range from pH 3.5 to 4.5 and a temperature optimum around 50–55 °C at pH 5.5. Also, they exhibit strong binding to insoluble mutan with <i>K</i> <sub>D</sub> around 0.11 and 0.13 μm at pH 7 for the <i>P. purpurogenum</i> and<i>T. harzianum</i> mutanases, respectively. Partial hydrolysis showed that the COOH<i>-</i>terminal domain of the <i>T. harzianum</i> mutanase binds to mutan. The catalytic domains and the binding domains were assigned to a new family of glycoside hydrolases and to a new family of carbohydrate-binding domains, respectively.
Comparative Study of Multiplet Structures of Mn<sup>4+</sup> in K<sub>2</sub>SiF<sub>6</sub>, K<sub>2</sub>GeF<sub>6</sub>, and K<sub>2</sub>TiF<sub>6</sub> Based on First-Principles Configuration–Interaction Calculations (2012)

We performed first-principles configuration–interaction calculations of multiplet energies for Mn 4+ in K 2 SiF 6 , K 2 GeF 6 , and K 2 TiF 6 crystals. The results indicate that corrections based on a single-electron calculation are effective for the prediction of 4 A 2 → 4 T 2 and 4 A 2 → 4 T 1a transition energies, while such corrections are not necessary for the prediction of the 4 A 2 → 2 E transition energy. The cluster size dependence of the multiplet energies is small. However, the 4 A 2 → 2 E transition energy is slightly improved by using larger clusters including K ions. The theoretical multiplet energies are improved further by considering the lattice relaxation effect. As a result, the characteristic multiplet energy shifts depending on the host crystal are well reproduced without using any empirical parameters. Although K 2 GeF 6 and K 2 TiF 6 have lower symmetry than K 2 SiF 6 , the results indicate that the variation of the multiplet energy is mainly determined by the Mn–F bond length.
Avalanche Transistor Pulser for Fast-Gated Operation of Microchannel Plate Image-Intensifiers (1978)

Transistors operated in the avalanche mode are employed to generate a 1000 volt 10 to 30 nsec wide pulse with < 4 nsec rise and fall times. This pulse is resistively attenuated to ≃ 270 volts and drives the image intensifier tube which is a load of ≃ 200 pf. To reduce stray inductance and capacitance, transistor chips were assembled on a thick-film hybrid substrate. Circuit parameters, operating conditions, and coupling to the microchannel plate image-intensifier (MCPI2) tube are described. To provide dc operating voltages and control of transient voltages on the MCPI2 tube a resistance-capacitance network has been developed which (a) places the MCPI2 output phosphor at ground, (b) provides programmable gains in "f-stop" steps, and (c) minimizes voltage transients on the MCPI2 tube.
Circuits for Digital X‐Ray Imaging: Counting and Integration (2009)

This chapter contains sections titled: Introduction Circuit Implementation Experimental Results Conclusion References
Advances in elliptical-core two-mode optical fiber sensors (1990)

Methods designed to improve the practicality of the elliptical-core two-mode optical fiber sensors for use in real-life applications are presented. The improvements include the development of insensitive lead fibers and an optical device which allows fringe counting at the output of the sensor. The insensitive leads eliminate extraneous perturbations and effectively isolate the sensing region. The fringe counting optics are designed to generate quadrature-phase shifted signals, thereby allowing the determination of whether the strain is increasing or decreasing. Work performed to advance the understanding of the effect of sensor placement within a composite specimen is also presented. Optical fiber sensors are embedded between different laminae of a graphite-epoxy composite panel, and the outputs of the sensors are shown to be proportional to the distance of the sensor from the neutral axis.
mRNA Cap Modification through Carbamate Chemistry: Synthesis of Amino‐ and Carboxy‐Functionalised Cap Analogues Suitable for Labelling and Bioconjugation (2015)

Abstract A simple and efficient synthesis of dinucleotide mRNA 5′ cap analogues functionalised by the addition of an amine or carboxylic acid group onto one of the ribose rings is reported. Selection of the modification sites was dictated by the recognition specificity for the 5′ cap by various cap‐binding proteins, including eIF4E, DcpS, and Dcp2, as well as by bacteriophage RNA polymerase, which enables the incorporation of the synthetic cap into the mRNA chain. Some analogues were further modified by O‐to‐CH 2 substitution in the triphosphate bridge to confer resistance to specific hydrolases. Spatial crowding and structural rigidity were balanced by use of diamines and amino acids of different lengths attached to the ribose through a carbamate moiety. The impact of these substitutions on the conformational equilibria of the ribose components was investigated by 1 H NMR spectroscopy. The utility of the analogues for labelling with fluorescent dyes and affinity tags was demonstrated with the aid of NHS activation chemistry.
Study on the Thermal Shock Resistance of Si<sub>3</sub>N<sub>4</sub>/TiC Nanocomposite Ceramic Tool Materials (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
HETEROSIS IN SUMMER RAPE (<i>Brassica napus</i> L.) (1983)

The degree of heterosis for seed yield in F 1 hybrids of summer rape (Brassica napus L.) was examined in replicated yield trials during 2 yr (1980 and 1981) using intervarietal hybrids produced by manual crossing. The seed yields from the F 1 hybrids of crosses between Marnoo and Regent, and Karat and Regent exceeded those of Regent by 38 and 43%, respectively. With the possible exception of maturity, which was 1 day later than Regent, the agronomic and quality characteristics of these hybrids appeared to be within the ranges acceptable in commercial rapeseed cultivars. However, the successful development of hybrid rapeseed cultivars still depends upon the development of a suitable cytoplasmic, genetic or chemical (male gametocide) pollination control system.Key words: Brassica napus L., canola, intervarietal hybrids
Slit‐flow ektacytometry: Laser diffraction in a slit rheometer (2005)

The newly developed slit ektacytometer can measure RBC deformability with ease and accuracy. In addition, the slit ektacytometer can be easily used in a clinical setting owing to the incorporation of a disposable element that holds the blood sample.
Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models (2012)

Brain microvascular endothelial cells (BEC) constitute the blood-brain barrier (BBB) which forms a dynamic interface between the blood and the central nervous system (CNS). This highly specialized interface restricts paracellular diffusion of fluids and solutes including chemicals, toxins and drugs from entering the brain. In this study we compared the transcriptome profiles of the human immortalized brain endothelial cell line hCMEC/D3 and human primary BEC. We identified transcriptional differences in immune response genes which are directly related to the immortalization procedure of the hCMEC/D3 cells. Interestingly, astrocytic co-culturing reduced cell adhesion and migration molecules in both BECs, which possibly could be related to regulation of immune surveillance of the CNS controlled by astrocytic cells within the neurovascular unit. By matching the transcriptome data from these two cell lines with published transcriptional data from freshly isolated mouse BECs, we discovered striking differences that could explain some of the limitations of using cultured BECs to study BBB properties. Key protein classes such as tight junction proteins, transporters and cell surface receptors show differing expression profiles. For example, the claudin-5, occludin and JAM2 expression is dramatically reduced in the two human BEC lines, which likely explains their low transcellular electric resistance and paracellular leakiness. In addition, the human BEC lines express low levels of unique brain endothelial transporters such as Glut1 and Pgp. Cell surface receptors such as LRP1, RAGE and the insulin receptor that are involved in receptor-mediated transport are also expressed at very low levels. Taken together, these data illustrate that BECs lose their unique protein expression pattern outside of their native environment and display a more generic endothelial cell phenotype. A collection of key genes that seems to be highly regulated by the local surroundings of BEC within the neurovascular unit are presented and discussed.
Terephthalic Acid, Dimethyl Terephthalate, and Isophthalic Acid (2000)

The article contains sections titled: 1. Introduction 2. Physical Properties 3. Production 3.1. Amoco Oxidation 3.2. Amoco Purification 3.3. Multistage Oxidation 3.4. Dynamit-Nobel (Witten) Process 3.5. Esterification of Terephthalic Acid 3.6. Hydrolysis of Dimethyl Terephthalate 3.7. Alternative and Past Technologies 4. Environmental Protection 5. Quality Specifications 6. Storage and Transportation 7. Uses 8. Economic Aspects 9. Toxicology and Occupational Health
Prevalence of Chronic Pain in a Representative Sample in the United States (2008)

The population prevalence of chronic pain in the United States was lower than previously reported, with smaller sex-related differences and some variation by race/ethnicity.
Elastic properties of the titanium alloy Ti-6Al-4V (2015)

The manuscript presents results of Young's modulus (E) measurements for two-phase titanium alloy Ti-6Al-4V. The estimation of elasticity modulus (E) was made using three independent methods: standard mechanical tests (tensile test) on an electronic dynamometer “Instron”, the method measurement of sound speed propagation and the method of nanoindentation using nanohardness – testing scanning machine “Nanoscan3D”. The elastic properties were studied for Ti-6Al-4V alloy in different structural states: nanostructured (NS), microcrystalline (MC) and coarse-grained (CG). The elastic modulus α - and β - phases were measured by means of nanoindatation methods. It is shown that a value of elasticity modulus E for the Ti – 6Al – 4V alloy in the CG state is less than in the NS state by more than 20% that is likely to be attributed to the change in amount ratio between α and β phases characterized by different elastic properties.