gebhart/patrepeval huggingface dataset:
Sequence-Specific DNA Minor Groove Binders. Design and Synthesis of Netropsin and Distamycin Analogues (1998)

ADVERTISEMENT RETURN TO ISSUEReviewNEXTSequence-Specific DNA Minor Groove Binders. Design and Synthesis of Netropsin and Distamycin AnaloguesChristian Bailly and Jonathan B. ChairesView Author Information INSERM U-124 et Laboratoire de Pharmacologie Antitumorale Moléculaire du Centre Oscar Lambret, IRCL, Place de Verdun, 59045 Lille, France, and Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216-4505Cite this: Bioconjugate Chem. 1998, 9, 5, 513–538Publication Date (Web):June 23, 1998Publication History Received13 January 1998Revised5 May 1998Published online23 June 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/bc980008mhttps://doi.org/10.1021/bc980008mreview-articleACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views2147Altmetric-Citations216LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Conjugate acid-base pairs,Genetics,Molecules,Nucleic acid structure,Peptides and proteins Get e-Alerts
Effect of albumin supplementation during parenteral nutrition on hospital morbidity (1988)

Because several studies have shown a significant inverse correlation between depressed serum concentrations of albumin and hospital morbidity, a study with central total parenteral nutrition (TPN) with normal serum albumin (NSA) in hypoalbuminemic patients was conducted. Sixty-one patients who required central TPN were randomized into one of two groups: group 1 (n = 31) received TPN plus NSA (25 to 37.5 g/day) until their measured serum albumin was greater than 3 g/dl, and group 2 (n = 30), who received TPN alone. All patients were followed for hospital complications until discharge or death. The groups were well matched for age, sex, major diagnoses, initial serum albumin concentrations, hospital complications before TPN, and number of operative procedures. Both groups received comparable doses of energy (37.2 +/- 89 vs. 3.30 +/- 6.2 kcal/kg.day) and protein (1.6 +/- 0.4 vs. 1.6 +/- 0.3 g/kg.day). After initiation of TPN, there were significantly more hospital complications in group 2 (1 = 1.1 +/- 1.4, n = 33; 2 = 2.6 +/- 3.0, n = 80, p less than .01). When complications in the patient groups were stratified, significantly more patients in group 2 developed pneumonia (18 vs. 9, p less than .05) and septicemia (11 vs. 2, p less than .05). Increasing serum albumin concentrations with NSA in hypoalbuminemic patients receiving central TPN appears to be associated with a reduction in hospital morbidity.
Mobility analysis of the large adaptive reflector antenna reflector (2002)

The motion of the three-tethered balloon system in the large adaptive reflector antenna is analyzed. First, the motion scale of the balloon in the sky is investigated, which is composed by three different spherical surfaces. Second, different materials always cause different static and dynamic deformation of the tether, so the affect of the material to the stability of the motion of balloon is discussed by using the scaled-down model for laboratory use. Third, the influence of the motion pattern of each tether to the motion stability of the balloon is given.
Switching Roller Finger Follower Meets Lifetime Passenger Car Durability Requirements (2012)

<div class="section abstract"><div class="htmlview paragraph">An advanced variable valve actuation (VVA) system is characterized following end-of-life testing to enable fuel economy solutions for passenger car applications. The system consists of a switching roller finger follower (SRFF) combined with a dual feed hydraulic lash adjuster and an oil control valve that are integrated into a four cylinder gasoline engine. The SRFF provides discrete valve lift capability on the intake valves. The motivation for designing this type of VVA system is targeted to improve fuel economy by reducing the air pumping losses during part load engine operation. This paper addresses the durability of a SRFF for meeting passenger car durability requirements. Extensive durability tests were conducted for high speed, low speed, switching, and cold start operation. High engine speed test results show stable valvetrain dynamics above 7000 engine rpm. System wear requirements met end-of-life criteria for the switching, sliding, rolling and torsion spring interfaces. One important metric for evaluating wear is to monitor the change in valve lash. The lifetime requirements for wear showed that lash changes are within the acceptable window. The mechanical aspects exhibited robust behavior over all tests including the slider interfaces that contain a diamond like carbon (DLC) coating. A DLC coating was chosen to allow higher slider interface stresses in a compact package. Testing results show that this technology is robust and meets all lifetime requirements with some aspects extending to six times the useful life requirements.</div></div>
Mechanism of Molten KOH Etching of SiC Single Crystals: Comparative Study with Thermal Oxidation (1999)

The etching mechanism of SiC single crystals by molten KOH has been investigated. The etching process is significantly affected by the etching ambience: the etching rate is greatly reduced by a nitrogen gas purge. This result clearly suggests an essential role of dissolved oxygen in the melt. SiC{0001} surfaces show a large surface polarity dependence, where the etching rate of SiC(0001)C is about four times larger than that of SiC(0001)Si. The etching rate of SiC(0001)C exhibits an Arrhenius type temperature dependence with an activation energy of 15–20 kcal/mol. The obtained activation energy and selectivity between the (0001)C and the (0001)Si surfaces are quite similar to those for thermal oxidation, which implies that the surface oxidation process occurs during molten KOH etching of SiC and is the rate-limiting step for the etching. We have conducted a comparative study of molten KOH etching with thermal oxidation in regard to the crystal orientation, polytype and carrier concentration dependence.
Controls on topographic dependence and temporal instability in catchment‐scale soil moisture patterns (2013)

Key Points Type of topographic dependence mainly depends on soil & vegetation properties Temporal instability increases if lateral flow & radiative ET are balanced Soil & vegetation properties mainly determine if the dominant process changes
Presence of Viremia in Patients with Primary Herpetic Gingivostomatitis (2004)

PCR detected viremia in 34% of patients with primary herpetic gingivostomatitis. Presence of viremia may play a potential role in viral dissemination, providing a better understanding of the pathogenesis of HSV infections, especially of the central nervous system.
Facts and fictions about polymorphism (2015)

We present new facts about polymorphism based on (i) crystallographic data from the Cambridge Structural Database (CSD, a database built over 50 years of community effort), (ii) 229 solid form screens conducted at Hoffmann-La Roche and Eli Lilly and Company over the course of 8+ and 15+ years respectively and (iii) a dataset of 446 polymorphic crystals with energies and properties computed with modern DFT-d methods. We found that molecular flexibility or size has no correlation with the ability of a compound to be polymorphic. Chiral molecules, however, were found to be less prone to polymorphism than their achiral counterparts and compounds able to hydrogen bond exhibit only a slightly higher propensity to polymorphism than those which do not. Whilst the energy difference between polymorphs is usually less than 1 kcal mol(-1), conformational polymorphs are capable of differing by larger values (up to 2.5 kcal mol(-1) in our dataset). As overall statistics, we found that one in three compounds in the CSD are polymorphic whilst at least one in two compounds from the Roche and Lilly set display polymorphism with a higher estimate of up to three in four when compounds are screened intensively. Whilst the statistics provide some guidance of expectations, each compound constitutes a new challenge and prediction and realization of targeted polymorphism still remains a holy grail of materials sciences.
Estimation of capillary reflection coefficients and unique PS products in dog paw (1989)

Lymphatic protein flux (Js) obtained in canine hindpaws at low lymph flows were used to determine the capillary osmotic reflection coefficients (sigma d) and unique permeability surface area (PS) products for total proteins, albumin, immunoglobulin (Ig)G, and IgM. This new analysis is based on the phenomenon that when maximal diffusion occurs across the capillary membrane, the Peclet number [x = Jv(1 - sigma d)/PS] attains a unique value defined only by sigma d. The diffusive flux is maximal when the relationship between protein flux and transcapillary fluid flux (Jv) changes from a curvilinear to a linear relationship. The slope of the linear portion of this protein flux relationship was used to determine sigma d as (1 - sigma d) = delta Js/(delta JvCp), where Cp is the plasma protein concentration. With the use of sigma d, the Jv at which the maximal diffusion occurred, and the corresponding Peclet number, a unique value is obtained for the PS product. Experiments performed using lymph from canine hindpaws (n = 6) yielded sigma d's (mean +/- SD) of 0.91 +/- 0.03, 0.83 +/- 0.11, 0.96 +/- 0.03, and virtually 1 for total protein, albumin, IgG, and IgM, respectively. The corresponding PS products for total protein, albumin, and IgG were 25.0 +/- 13.2, 28.4 +/- 6.6, and 14.0 +/- 7.9 microliters.min-1.100 g-1, respectively; PS for IgM was almost zero.(ABSTRACT TRUNCATED AT 250 WORDS)
Inhibition of bioactivity of UASB biogranules by electroplating metals (1997)

Abstract
Introduction to MPEG-7: Multimedia Content Description Interface (2002)

From the Publisher:
The MPEG standards are an evolving set of standards for video and audio compression. MPEG 7 technology covers the most recent developments in multimedia search and retreival, designed to standardise the description of multimedia content supporting a wide range of applications including DVD, CD and HDTV.
Multimedia content description, search and retrieval is a rapidly expanding research area due to the increasing amount of audiovisual (AV) data available. The wealth of practical applications available and currently under development (for example, large scale multimedia search engines and AV broadcast servers) has lead to the development of processing tools to create the description of AV material or to support the identification or retrieval of AV documents. Written by experts in the field, this book has been designed as a unique tutorial in the new MPEG 7 standard covering content creation, content distribution and content consumption. At present there are no books documenting the available technologies in such a comprehensive way.
Presents a comprehensive overview of the principles and concepts involved in the complete range of Audio Visual material indexing, metadata description, information retrieval and browsingDetails the major processing tools used for indexing and retrieval of images and video sequencesIndividual chapters, written by experts who have contributed to the development of MPEG 7, provide clear explanations of the underlying tools and technologies contributing to the standardDemostration software offering step-by-step guidance to the multi-media system components and eXperimentation model (XM) MPEG reference softwareCoincides with the release of the ISO standard in late 2001.
A valuable reference resource for practising electronic and communications engineers designing and implementing MPEG 7 compliant systems, as well as for researchers and students working with multimedia database technology.
Preparation of Compounds Labeled with Tritium and Carbon‐14 (2009)

Preparation of compounds labeled with tritium and carbon-14 , Preparation of compounds labeled with tritium and carbon-14 , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
Cross-language image retrieval via spoken query (2004)

This paper studies cross-language cross-medium information retrieval. We introduce several approaches to unify the languages and media of queries and documents. We experiment on cross-language image retrieval via spoken query. Two approaches are proposed to recognize and translate spoken queries. We also propose a similarity-based approach to identify and backward transliterate named entities in a spoken query. 1.
Fluorescent proteins for single‐molecule fluorescence applications (2008)

We present single-molecule fluorescence data of fluorescent proteins GFP, YFP, DsRed, and mCherry, a new derivative of DsRed. Ensemble and single-molecule fluorescence experiments proved mCherry as an ideally suited fluorophore for single-molecule applications, demonstrated by high photostability and rare fluorescence-intensity fluctuations. Although mCherry exhibits the lowest fluorescence quantum yield among the fluorescent proteins investigated, its superior photophysical characteristics suggest mCherry as an ideal alternative in single-molecule fluorescence experiments. Due to its spectral characteristics and short fluorescence lifetime of 1.46 ns, mCherry complements other existing fluorescent proteins and is recommended for tracking and localization of target molecules with high accuracy, fluorescence resonance energy transfer (FRET), fluorescence lifetime imaging microscopy (FLIM), or multicolor applications.
Effectiveness of Text Representations in the Automatic Classification of Regional Game Design Trends in Video Game Reviews (2019)

The video game industry is one of the fastest growing segments of the global entertainment market, and thus represents the design decisions of a wide spectrum of developers. This paper seeks to show that text mining can be used to predict trends in game design by identifying the region and release date automatically from video game reviews. When framed as a multi-class classification problem, a Support Vector Machine (SVM) achieves an average predictive confidence of 30.27% for noun and verb text representations, or by individual text representation: text windowing 11.22%, noun phrases 32.15%, noun phrases without game titles 31.40%, noun phrases with verbs 29.66%, individual term 27.88%. The SVM achieved better performance of 52.93% when predicting the release date trained on nouns and verbs. By text representation, the classifier found: noun phrases 62.97%, noun phrases without game titles 55.13%, noun phrases with verbs 61.10%, individual term 36.51% features.
Cached Long Short-Term Memory Neural Networks for Document-Level Sentiment Classification (2016)

Recently, neural networks have achieved great success on sentiment classification due to their ability to alleviate feature engineering. However, one of the remaining challenges is to model long texts in document-level sentiment classification under a recurrent architecture because of the deficiency of the memory unit.
The Bcl-2 Oncoprotein Functions as a Pro-oxidant (1995)

The mechanism by which the bcl-2 oncogene exerts its anti-apoptotic and antioxidant action is unknown. We found that expression of bcl-2 in superoxide dismutase-deficient (SOD-) Escherichia coli resulted in increased transcription of the KatG catalase-peroxidase, a 13-fold increase in KatG activity and a 100-fold increase in resistance to hydrogen peroxide. In addition, mutation rate was increased 3-fold, and katG and oxyR, a transcriptional regulator of katG induction, were required for aerobic survival. These data indicate that Bcl-2 acts as a pro-oxidant in E. coli, i.e. Bcl-2 generates reactive oxygen intermediates. In support of a pro-oxidant mechanism in eukaryotic cells, we found a 73% increase in superoxide dismutase activity in a murine B-cell line overexpressing Bcl-2. Increases in reduced glutathione and in oxyradical damage to DNA, previously observed in other overexpressing cell lines, are additional evidence for a pro-oxidant mechanism. Thus, Bcl-2 does not appear to be an antioxidant. Instead, Bcl-2 appears to influence levels of reactive oxygen intermediates that induce endogenous cellular antioxidants. This activity of Bcl-2 may control entry into apoptosis.
Fractionation of Caseins Directly from Skimmilk by Gel Chromatography. 2. Elution with Phosphate Buffers (1972)

n-Casein was separated on Sephadex G-100 by eluting with 0.01 ~ borate, pH 10 at 25 C or 0.01 M phosphate, pit 11 at 4 C. Phosphate, 5 m~ with 2 mM Na ethylenediaminetetraacetate, pH 10.8, was used for continuous fractionation at 4 C to retard bacterial growth in the gel. ~-Casein was collected from the first half of the first peak. The stabilizing ability o~ the K-casein against Ca-asl-caseinate precipitation was slightly low possibly from contamination with minor members of the a~-casein group. Electrophoretically pure t-casein was obtained from the first half of the second peak after elimination of contaminating a~-easein by precipitation at pH 4.4 and 4 C. a~-Cascin was purified from the last half of the second peak by precipitating with 0.1 ~ CaClo. The phosphate method was superior to the sodium dodecylsulfate method because of faster elution, being more reproducible, and without extraction to remove bound dodecylsulfate, a~-, fl-, n-Caseins were fractionated directly from skimnfilk, however, the yield of n-casein was approximately half of that by the sodium dodecylsulfate method.
Effects of Ti-Capping on Formation and Stability of Co Silicide. I. Solid Phase Reaction of Ti to Co/Si System (2000)

We have investigated the formation and thermal stability of Co silicide on Si using a Ti‐cap. We propose that Ti retards the reaction between Co and the Si substrate and also prevents oxygen contamination. The Ti‐capped has a higher transformation temperature and thinner film thickness than TiN‐capped . A 15 nm thick Ti‐cap provides a layer with a more uniform interface and higher thermal stability compared to layers with a TiN‐cap. The increased uniformity of the silicide/Si interface results from the retarded Co‐Si reaction, due to the formation of a CoTi binary phase. The high thermal stability can be explained by a Ti‐stuffing model. From analysis of the depth profile, it is likely that surface Ti diffuses rapidly into the grain boundaries and slows the agglomeration process, thereby increasing the thermal stability. As a result, Ti‐capped Co silicide formed on a 0.15 μm wide polycrystalline Si gate shows a thermal budget limit as high as 900°C for 30 min. Based on the results of capacitance‐voltage and time‐dependent dielectric breakdown measurements, we can conclude that Ti‐capped Co silicide is a candidate as a gate electrode for high thermal budget devices such as logic with embedded dynamic random access memory. © 2000 The Electrochemical Society. All rights reserved.
Molecular characterization of the tobacco SET domain protein NtSET1 unravels its role in histone methylation, chromatin binding, and segregation (2004)

Plants contain a great number of genes encoding a distinctive class of SET domain proteins which harbor a plant-specific N-terminal part together with a C-terminal part showing highest sequence similarity to the catalytic domain of the yeast CLR4, the human SUV39H1 and G9a histone-methyltransferases (HMTases). Here we show that NtSET1, a representative member of this class from tobacco, methylated both K9 and K27 of histone H3 in vitro. Ectopic expression of NtSET1, by an inducible promoter, increased the amount of dimethylated H3K9 and induced chromosome-segregation defects in tobacco BY2 cells. Deletion analyses show that the HMTase activity, the association with specific chromatin regions and with condensed chromosomes, and the cellular effects largely depended on the C-terminal region including the SET domain of the protein. Nevertheless, the N-terminal part of NtSET1 was capable of targeting the green fluorescent protein to interphase chromatin. Finally, we show that NtSET1 bound LHP1, the Arabidopsis homolog of animal heterochromatin protein 1 (HP1), and that LHP1 co-localized with heterochromatin containing high amounts of dimethylated H3K9, suggesting a role for NtSET1 in heterochromatic function. Taken together, our results provide new insights into the molecular and global chromatin-binding activities of this particular class member of plant SET domain proteins.
Differential Chromosome Sensitivity to 5-Azacytidine in Alzheimer’s Disease (1998)

These results suggest that the demethylating action of 5-AZC could reveal differential gene activity in the Alzheimer group at the level of cellular division.
<i>In Situ</i> Preparation of TiO<sub>2</sub> Composite Layer upon Ti Alloy Substrate Using Micro-Arc Oxidation and its Photocatalytic Property (2010)

In this paper, a micro-arc oxidation (MAO) approach is introduced for “in-situ” preparing TiO2 composite layer upon the surface of titanium alloy (Ti-6Al-4V) substrate. The surface morphologies, chemical compositions, crystal microstructure and photocatalytic properties of the layers were investigated by using a field emission scanning electron microscope (FE-SEM), energy dispersive spectrometer (EDS), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), electro-chemical workstation and UV-Vis spectrophotometer. The experimental results revealed that photocatalytic performance of the TiO2 composite layers was much higher than that of the pure TiO2 layer and also exhibited absorption under the visible light irradiation.
Aluminum Mill and Engineered Wrought Products (1990)

Abstract Aluminum mill products are those that have been subjected to plastic deformation by hot- and cold-working mill processes such as rolling, extruding, and drawing, either singly or in combination. Microstructural changes associated with the working and with any accompanying thermal treatments are used to control certain properties and characteristics of the worked, or wrought, product or alloy. This article discusses the designation system, classification, product forms, corrosion and fabrication characteristics, and applications of wrought aluminum alloys. Commercial wrought aluminum products are divided into flat-rolled products (sheet, plate, and foil); rod, bar, and wire; tubular products; shapes; and forgings. The article discusses factors affecting the strengthening mechanisms, fracture toughness, and physical properties of aluminum alloys, in addition to the effects of alloying on the physical and mechanical properties. Important alloying elements and impurities are listed alphabetically as a concise review of major effects.