gebhart/patrepeval huggingface dataset:
Spatial models for context-aware indoor navigation systems: A survey (2012)

This paper surveys indoor spatial models developed for research fields ranging from mobile robot mapping, to indoor location-based services (LBS), and most recently to context-aware navigation services applied to indoor environments. Over the past few years, several studies have evaluated the potential of spatial models for robot navigation and ubiquitous computing. In this paper we take a slightly different perspective, considering not only the underlying properties of those spatial models, but also to which degree the notion of context can be taken into account when delivering services in indoor environments. Some preliminary recommendations for the development of indoor spatial models are introduced from a context-aware perspective. A taxonomy of models is then presented and assessed with the aim of providing a flexible spatial data model for navigation purposes, and by taking into account the context dimensions.
Simulation of experimentally observed dilation phenomena during integral gas sorption in glassy polymers (2007)

Abstract A molecular modeling investigation of dilation effects induced by sorbed gas molecules in two glassy polymers is presented. As experimental reference, integral sorption of CO 2 and CH 4 was measured for polysulfone (PSU) and a polyimide (6FDA‐TrMPD, PI4) at 308 K and a pressure of 10 bar. Simultaneously, the gas induced swelling effect was measured with a dilatometer based on a capacitive distance sensor recorded. The experimental evidence of the (on the observed time scale and concentration levels) elastic nature of the gas induced dilation is supported by the dilation and contraction behavior observed in molecular dynamics (MD) simulations of respective detailed atomistic packing models. These models were constructed in accordance with gas concentration levels obtained from the experimental sorption results. Quantitative deviations between simulated and measured dilations are discussed as a consequence of an anelastic response of the polymer matrix which is too fast to be resolved in the experiments whose kinetics is dominated by diffusional processes. In the simulation, the initial insertion of penetrant molecules into equilibrated packing models “circumvents” the slow diffusional process of the experiment and allows a reasonable representation of the dilation process as well as a closer investigation. Our simulation approach reveals a different behavior for PSU and PI4 on the corresponding time scale. Most likely, the different chain mobility of the two polymers is responsible for the respective response to the inserted amount of gas molecules which is discussed in terms of the different chain mobilities of the two polymers. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 46: 59–71, 2008
Analysis of the optical properties of bile (2000)

Invasive bile determination is very useful in the diagnosis of many gastric pathologies. At the moment, this measurement is performed with Bilitec 2000, an optical fiber sensor, that is based on absorption by bilirubin. Nevertheless, erroneous evaluations are possible, due to the different configurations which the bilirubin molecule can adopt. The optical behavior of human samples of pure bile and bile+gastric juice has been examined using an optical fiber spectrophotometer and two suitably modified Bilitec 2000 units. A protocol has been established for the treatment of biological fluids, in order to make it possible to study the behavior of their optical properties as a function of pH and concentration without causing any alteration in the samples. The analysis of pH dependence evidenced the presence of different calibration curves at different pH values: the self-aggregation of the bilirubin molecules observed in pure bile samples was almost totally absent in the gastric samples. Measurements carried out on Bilitec 2000 showed that the most appropriate wavelength for bilirubin detection in the stomach should be 470 nm.
Synthesis and Structure−Activity Relationships of Suramin-Derived P2Y<sub>11</sub>Receptor Antagonists with Nanomolar Potency (2005)

Selective and potent P2Y(11) receptor antagonists have yet to be developed, thus impeding an evaluation of this G protein-coupled receptor mainly expressed on immune cells. Taking suramin with moderate inhibitory potency as a template, 18 ureas with variations of the methyl groups of suramin and their precursors were functionally tested at P2Y(11), P2Y(1), and P2Y(2) receptors. Fluorine substitution of the methyl groups of suramin led to the first nanomolar P2Y(11) antagonist (8f, NF157, pK(i): 7.35). For selectivity, 8f was also tested at various P2X receptors. 8f displayed selectivity for P2Y(11) over P2Y(1) (>650-fold), P2Y(2) (>650-fold), P2X(2) (3-fold), P2X(3) (8-fold), P2X(4) (>22-fold), and P2X(7) (>67-fold) but no selectivity over P2X(1). QSAR studies confirm that residues with favored resonance and size parameters in the aromatic linker region can indeed lead to an increased potency as is the case for 8f. A symmetric structure linking two anionic clusters seems to be required for bioactivity. 8f may be helpful for studies evaluating the physiological role of P2Y(11) receptors.
Mesenteric Artery Contractile Properties During Dietary Calcium Manipulation in Spontaneously Hypertensive and Wistar Kyoto Normotensive Rats (1989)

The hypothesis that elevated Ca2+ intake lowers blood pressure in the spontaneously hypertensive rat (SHR) by altering intrinsic contractile properties of vascular smooth muscle was tested. The effect of 0.5, 1, and 2% Ca2+ in the diet on systolic blood pressure, serum-ionized Ca2+, and contractile properties of mesenteric arteries isolated from SHR and normotensive Wistar-Kyoto (WKY) rats maintained on diets for 6 and 12 weeks was examined. Blood pressure was significantly elevated in SHR on 0.5% Ca2+ diets after both 6 and 12 weeks, as well as in WKY receiving 1% Ca2+. After six weeks on the diets for the SHR and 6 and 12 weeks for the WKY, serum-ionized Ca2+ was a function of the amount of Ca2+ in the diet. When contractile force generation in response tp KCl or norepinephrine was examined, small diet-related differences were detected, but no consistent linear effect associated with the level of Ca2+ in the diet was observed in either strain. When the sensitivity of the vessels to KCl and norepinephrine was examined, no effects of oral Ca2+ intake were detected. The results indicate that oral Ca2+ loading has modest effects on blood pressure at both 12 and 18 weeks of age in the SHR and WKY and in the younger rat, where Ca2+ intake modulates serum ionized Ca2+ levels. At no age does modification of Ca2+ intake have a consistent effect on mesenteric artery sensitivity or force-generating ability in response to KCl or norepinephrine. These findings do not support the hypothesis that oral Ca2+ loading lowers blood pressure in the rat by altering intrinsic contractile properties of vascular smooth muscle.
Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy. (2003)

Our results show a link between the MTHFR polymorphism and tumor response to fluoropyrimidine-based chemotherapy and suggest that MTHFR genotyping may be of predictive benefit in selecting treatment regimens.
Comparative study on paralleling schemes of converter modules for distributed power applications (1998)

Three different paralleling schemes for multimodule converters are investigated. For each paralleling scheme, benefits and limitations are addressed for distributed power applications, and guidelines for designing the feedback controller are presented. Results of the analysis are verified by both frequency and time-domain simulations.
Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release (2011)

In solid malignant tumors, lactate has been identified as a prognostic parameter for metastasis and overall survival of patients. To investigate the effects of lactate on tumor cell migration, Boyden chamber assays were applied. We could show here that lactate enhances tumor cell motility of head and neck carcinoma cell lines significantly in a dose-dependent manner. The changes in tumor cell migration could be attributed to L-lactate or a conversion of lactate to pyruvate, as only these two substances were able to increase migration. Addition of D-lactate or changes in osmolarity or intracellular pH did not alter the migratory potential of the cells investigated. Because lactate was shown earlier to impair the penetration of dendritic cells in a tumor spheroid model, which is contrary to the response of the malignant cell population in the present study, we included blood monocytes in our assay as a highly motile immune cell type and precursor of tumor-associated macrophages. Interestingly, high levels of L-lactate (20 mM) at a pH of 7.4 inhibited monocyte migration in the Boyden chamber system. In addition, cytokine release of TNF and IL-6 was inhibited. The obtained data suggest that high lactate content promotes tumor progression by contributing to the phenomenon of tumor immune escape and by enhancing the migratory potential of the malignant cell population which may directly be coupled to a higher incidence of metastasis.
Inhibition of human neutrophil receptor-mediated uptake of N-formyl-met-leu-phe by platelet factor 4 (59-70). (1985)

Human platelet factor 4 (PF4) and a substituent dodecapeptide designated PF4(59-70) elicited human neutrophil and monocyte chemotaxis with a similar concentration-dependence and maximal responses equal to that attained by chemotactic fragments of C5 (C5fr). At maximally chemotactic concentrations, PF4(59-70) stimulated the secretion by neutrophils of approximately 40% and 60% of the respective quantities of beta-glucuronidase and beta-glucosaminidase released by 10(-6) M N-formyl-methionyl-leucyl-phenylalanine (fMLP). In contrast to the deactivation of chemotaxis achieved by preincubation of neutrophils with other chemotactic factors, prior exposure to 10(-6)M PF4(59-70) for 2 min, or 20 min at 37 degrees, enhanced by 1.5- to 2-fold the chemotactic responses of neutrophils evoked by optimal concentrations of fMLP, C5fr, leukotriene B4, and PF4(59-70). Concentrations of PF4(59-70) which enhanced neutrophil chemotaxis inhibited the rate of receptor-mediated internalization of [3H]fMLP at 37 degrees and 18 degrees, but at 0 degrees failed to alter the binding affinity or the number of receptors for [3H]fMLP. Preincubation of neutrophils at 37 degrees with concentrations of PF4(59-70) which enhanced neutrophil chemotaxis also did not affect the subsequent binding of [3H]fMLP at 0 degrees. The inhibition by PF4(59-70) of the receptor-mediated internalization of [3H]fMLP was not mimicked by other positively charged compounds. The specific inhibition of receptor-mediated internalization of fMLP may explain the enhanced chemotactic responsiveness of neutrophils preincubated with PF4(59-70).
Optimization of Borehole Stability Using 3D Stress Optimization (2005)

Abstract Borehole stability has played an important role in the evolution of long and deep wells in later years. Borehole collapse and circulation losses are costly problems for the entire drilling industry. It is often assumed that high borehole inclination leads to lower mud weight margins. To investigate this aspect, a study of borehole stability in 3-dimensional space was undertaken. This paper presents results and applications of the findings in this study. The in-situ stress state plays a key role for borehole instability. The stress state is usually classified as normal fault, strike/slip fault and reverse fault stress states. One major conclusion of the study was that optimum stability was obtained for a lithostatic stress state, which is where all 3 normal borehole stresses are equal. For this case the window between fracturing and collapse was maximum. Bounds on the magnitude of the in-situ stresses were also invoked, resulting in a constrained 3-dimensional model that covered both fracturing and collapse pressures. Studying both fracturing and collapse pressures, it was found that maximum hole stability could be obtained at intermediate orientations, and that they are controlled be the magnitude and directions of the in-situ stresses. Field cases are also presented in the paper. It is shown that under optimal conditions combination of wellbore inclinations and azimuths can give the highest wellbore stability. The 3-dimensional fracture and collapse model presented is an efficient tool for well path optimization. Platform placement and planning of difficult wells can be improved by using this method. It is presented as analytical equations, and can easily be implemented in a calculator.
A Function for Kinesin I in the Posterior Transport of <i>oskar</i> mRNA and Staufen Protein (2000)

The asymmetric localization of messenger RNA (mRNA) and protein determinants plays an important role in the establishment of complex body plans. In Drosophila oocytes, the anterior localization of bicoid mRNA and the posterior localization of oskar mRNA are key events in establishing the anterior-posterior axis. Although the mechanisms that drive bicoid and oskar localization have been elusive, oocyte microtubules are known to be essential. Here we report that the plus end-directed microtubule motor kinesin I is required for the posterior localization of oskar mRNA and an associated protein, Staufen, but not for the anterior-posterior localization of other asymmetric factors. Thus, a complex containing oskar mRNA and Staufen may be transported along microtubules to the posterior pole by kinesin I.
Extremum seeking control with data-based disturbance feedforward (2014)

This paper presents a practical extension to the classical gradient-based extremum seeking control for the case when the disturbances responsible for the changes in the extremum of a related performance function can be measured. The additional information is used to improve accuracy, convergence speed and robustness of the underlying ESC scheme. Based on the disturbance measurements a map between them and the optimal inputs is iteratively constructed and used as an extremum seeking feedforward. A supervising state-machine is designed to regulate feedforward and search processes ensuring the latter is conducted in the close vicinity of an extremum. The search is based on the sinusoidal input perturbation introduced each time the disturbance is detected and removed once the optimal set-point is identified. Simulation results for the cases of photovoltaic and turbine driven electrical generator systems demonstrate the benefits of the presented design.
Thermal Properties of Aqueous Vesicle Dispersion Formed with Poly (oxyethylene) hydrogenated Castor Oil (1992)

The temperature dependence of particle size and properties on HCO-10 vesicle dispersion were studied by particle size analysis, ESR spin labelling, 1H-NMR and NIR spectra.The dehydration of oxyethylene groups in HCO-10 was found to occur with increase in temperature (above 40°C), with consequent reduction in the hydrophilicity of HCO-10. HCO-10 membranes in MLV vesicles easily coalesced each other between partiallly dehydrated polar head, finally giving rise to a large and unstable droplets by thermal agitation.
Reduced Levels of Tear Lacritin Are Associated With Corneal Neuropathy in Patients With the Ocular Component of Sjögren's Syndrome (2016)

Reduced tear lacritin levels in SS patients are highly correlated with clinical signs of dry eye, as well as decreased NFD and NFL. Lacritin and its components provide excellent diagnostic sensitivity and specificity in SS.
Multirate payload switching using a swappable optical carrier suppressed label in a packet-switched DWDM optical network (2005)

Optical packets with multirate payloads have been demonstrated for optical label switching (OLS) and transport in a multihop dense wavelength-division-multiplexed (DWDM) optical network with over 200 km fiber and a low-power penalty for the first time. The key functions for label generation, swapping, and switching have been successfully realized.
Functionalization of the Benzylic C–H Bonds in Azaarenes by Cobalt‐Catalyzed 1,4‐Addition to Enones (2014)

Abstract Functionalization of the C(sp 3 )–H bonds in azaarenes was catalyzed by CoCl 2 as an inexpensive Lewis acid catalyst. Enones were demonstrated to be good C=C electrophilic acceptors for the construction of various azaarene‐containing 1,4‐addition products in yields of up to 95 %.
LI.—<i>On a new species of the genus</i> Eupetomena (1875)

"LI.—On a new species of the genus Eupetomena." Annals and Magazine of Natural History, 16(95), p. 370
A Nb&lt;inf&gt;3&lt;/inf&gt;Sn dipole magnet reacted after winding (1985)

A 5 cm bore dia., 1-m-long dipole model magnet was constructed by winding un-reacted cable, followed by reaction and epoxy-impregnation. Experience and test results are described on the 1.7 mm dia. internal-tin wire, the eleven-strand flattened cable, fiberglass insulation, and construction of the magnet. Each half of the magnet has two double-pancake-type windings that were reacted in a single operation. The two double-pancakes were then separately vacuum impregnated after soldering the flexible Nb-Ti leads to the Nb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Sn conductors. No iron flux return yoke was used. In initial tests a central field of 8.0 T was reached at 4.4 K. However, evidence from training behavior, and 1.8 K tests indicate that premature quenching, rather than critical current of the cable, limited the field intensity. The magnet was reassembled and more rigidly clamped; additional test results are reported.
Zeaxanthin and the Heat Dissipation of Excess Light Energy in <i>Nerium oleander</i> Exposed to a Combination of High Light and Water Stress (1988)

Upon termination of watering of plants of Nerium oleander exposed to high light, photochemical efficiency became reduced as leaf water content decreased. Evidence is presented that this type of photoinhibition reflects to a substantial degree radiationless dissipation of excitation energy, probably mediated by the carotenoid zeaxanthin. During the imposition of water stress, the zeaxanthin content of leaves increased at the expense of violaxanthin and beta-carotene as a water deficit developed over a period of several days. The increase in zeaxanthin content was linearly related to an increase in the rate of radiationless energy dissipation in the antenna chlorophyll as calculated from the characteristics of chlorophyll a fluorescence measured with a pulse amplitude modulated fluorometer at room temperature. The increase in the rate of radiationless dissipation was also linearly related to a decrease in PSII photochemical efficiency as indicated by the ratio of variable to maximum fluorescence. Leaves of well-watered shade plants of N. oleander exposed to strong light showed a similar increase in zeaxanthin content as sun leaves of the same species subjected to drought in strong light. Shade leaves possessed the same capacity as sun leaves to form zeaxanthin at the expense of both violaxanthin and beta-carotene. The resistance of this species to the destructive effects of excess light appears to be related to interconversions between beta-carotene and the three carotenoids of the xanthophyll cycle.
High Temperature Creep of New L12 Containing Cobalt‐Base Superalloys (2012)

This chapter contains sections titled: Introduction Experimental Methods Microstructure and Physical Properties Single Crystal Tensile Creep Discussion Conclusions
Differential diagnosis of ovarian cancer with tumour markers CA 125, CA 15‐3 and TAG 72.3 (1993)

The risk of malignancy index incorporating CA 125, menopausal status and ultrasound is superior to the panel of three tumour markers for pre-operative differential diagnosis of the pelvic mass.
Comparison of two porcine (Sus scrofa domestica) skin models for in vivo near-infrared laser exposure. (2000)

On the basis of epidermal skin thickness measurements and melanin assessment, the flank and dorsal neck of the Yucatan minipig are better suited to laser injury studies than are the Yorkshire pig models of human skin.
Proton affinities of saturated aliphatic methyl esters (2000)

The kinetic method was used to determine the proton affinities of methyl esters of several saturated fatty acids. Decompositions of the proton-bound dimers of the methyl esters, AHB+, were observed under different conditions with two instruments. The proton affinities (PAs) of the methyl esters increase continually with increasing carbon number in the acid. Equilibrium and initial rate experiments were performed with a Fourier transform ion cyclotron resonance mass spectrometer on the methyl ester of the C22 saturated acid (methyl behenate). These experiments give values for PA (methyl behenate) that are perhaps slightly lower than those obtained with the kinetic method. The PAs of the methyl esters of the fatty acids could be correlated with the equation: PA (ester) = (40.0 +/- 2.5)*log(n) + (784.7 +/- 3.9) kJ/mol or PA (ester) = (864 +/- 2) - (479 +/- 41)/n, where n = number of atoms in the molecule. Proton affinities of smaller sets of 1-alkylamines and 1-alkanols can be fit to similar equations.
DEVELOPMENT OF PLUTONIUM-BEARING FUEL MATERIALS MONTHLY PROGRESS LETTER FOR MONTH OF JULY 1962 (1962)

Major effort during the report period was expended on the preparation and characterization of samples scheduled for in-pile screening tests. Other activities were continued on installation of hot metallographic cell installation and preparation and evaluation of UO/sub 2/-PuO/sub 2/ coprecipi tation processes. Data obtained in three preparation runs are included. A steady state intermediate production run was used to study the effects of ammonia evolved during the initial stages of mixed oxide precursor conversion on ADU precipitation. To determine whether or not selfreduction occurs, charges of the precursor were thermally decomposed in N/sub 2/ using fast and slow temperature rises on similar samples. Results are included which indicate that no significant amount of self-reduction occurs under these conditions. Effort is also continuing on development of techniques for producing spherical particles by mechanical agglomeration and sintering, and by plasma torch fusion. (J.R.D.)
Long-Term Results of Ossiculoplasty: Reasons for Surgical Failure (2005)

The overall long-term results of ossiculoplasty have not dramatically improved in recent years, in spite of all the great advances in biomedical technologies. Unless there is a breakthrough in the understanding and management of the underlying otitis media, the long-term outcome of ossiculoplasty is unlikely to improve dramatically.
Possible Correction of Defective Polymorphonuclear Cell Functions in Type‐2 Diabetes Mellitus by Met‐Enkephalin (1987)

In vitro pretreatment with Met-Enk of human PMNLs obtained from patients suffering from type-2 diabetes mellitus resulted in the normalization of the ROS generating system. It is assumed that Met-Enk has a modulating effect on the arachidonic acid metabolism, with a consecutive increase of the LTB4 release.