gebhart/patrepeval huggingface dataset:
Magnetron sputtered TiAlON composite thin films. I. Structure and morphology (1991)

Composite TiAlON thin films were deposited by rf magnetron sputtering from TiN–Al2O3 ceramic targets. Samples deposited under conditions that minimize the adatom mobility are attractive as decorative coatings due to their lustrous, black color and their wear resistance. The critical relationships between the processing parameters and the resulting microstructural features were investigated. Coatings with thicknesses ranging from 0.05 to 5 μm were characterized by x-ray and electron diffraction, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Thus, both the small scale ‘‘nanostructure’’ and the larger scale ‘‘microstructure’’ are described. It is shown that the observed features fit in the evolutionary model of microstructures. For ‘‘standard’’ conditions, the nanostructure consisted of crystallized grains (up to 10 nm in size) of a mixed nitride (Ti,Al)NX embedded in an amorphous mixed oxide (Ti,Al)O2. These two phases formed nanocolumns with a base diameter of 10 nm, separated by voided regions for very thin films (50 nm). These small scale features merged into microcolumns with a lateral size of 0.1 μm in films thicker than 1 μm. The low mobility regime produced important intercolumnar porosity. Increased adatom mobility induced by low energy particle bombardment affected both structural levels. The lattice parameter of the (Ti,Al)NX grains relaxed to 0.417 nm, value in the reported range for single phase metastable (Ti0.5Al0.5)N coatings. The bombardment interrupted the columnar growth and yielded a denser material. If in addition, the deposition conditions increased the energy of ejected species (for low argon pressures), segregation of metallic aluminium was observed together with the (Ti,Al)N grains. The microstructure became totally featureless up to a thickness of 1.8 μm.
Cancer and systemic sclerosis (2011)

These data suggest a model of paraneoplastic autoimmunity in which cross-reactive immune responses may target autoantigens that are expressed in both cancers and diseased autoimmune target tissues.
Performance of Flexible Sigmoidoscopy by a Clinical Nurse Specialist (1996)

According to the National Cancer Institute, 138,200 new cases and more than 55,000 deaths from colorectal cancer occurred in the U.S. in 1995. A high percentage of early cancers can be detected by screening asymptomatic persons older than age 50 with a digital rectal exam, fecal occult blood testing, and sigmoidoscopy. Evidence suggests that a decrease in mortality from colorectal cancer is associated with regular screening by sigmoidoscopy in an average risk population. As the population ages, more persons are eligible for colorectal cancer screening. Physician endoscopists are not available in all areas, and changes in reimbursement rates have caused some to discontinue this service. For these reasons, the Veterans Administration Medical Center in Buffalo, NY, developed a Colorectal Cancer Screening Program managed by a gastroenterology Clinical Nurse Specialist (CNS). Through study and supervision, the CNS has become proficient in the performance of 60-cm flexible sigmoidoscopic techniques and the diagnosis of multiple colon disorders, including sessile and pedunculated polyps, diverticulosis, tumors, hemorrhoids, and other conditions.
Optical properties of Zn3P2 (1979)

The optical properties of bulk and thin-film Zn3P2 have been measured at room temperature over the range 0.5–5.0 eV, with emphasis on the region of the interband absorption edge. The bulk absorption edge is found to be exponential in energy for values of absorption coefficient less than about 1500 cm−1. The thin-film absorption edge, when freed of spurious absorptance due to scattering, is also found to be exponential over this range although shallower in slope. Analysis of the thin-film data at higher values of absorption coefficient is inconclusive with respect to the nature of the edge. Nevertheless, indirect evidence suggests that the optical gap is probably direct and lies in the neighborhood of 1.6 eV. Measurements of refractive index in the near-infrared yield n=3.3±0.1 in the long-wavelength limit. The ultraviolet reflectivity spectrum is redetermined, and found to differ substantially from earlier reports. Results are discussed in terms of the Dow-Redfield model of exponential absorption edges, the effects of spin-orbit and crystal-field splittings, and effects arising from the equilibrium distribution of bond lengths peculiar to this material. It is concluded that the optical properties of Zn3P2 thin films are suitable for use in photovoltaic cells, provided antireflection coatings are employed.
Antagonism of 5‐HT<sub>1A</sub>receptors uncovers an excitatory effect of SSRIs on 5‐HT neuronal activity, an action probably mediated by 5‐HT<sub>7</sub>receptors (2008)

Both microdialysis and electrophysiology were used to investigate whether another serotonin (5-HT) receptor subtype next to the 5-HT(1A) autoreceptor is involved in the acute effects of a selective serotonin reuptake inhibitor on 5-HT neuronal activity. On the basis of a previous study, we decided to investigate the involvement of the 5-HT(7) receptors. Experiments were performed with the specific 5-HT(7) antagonist SB 258741 and the putative 5-HT(7) agonist AS19. In this study WAY 100.635 was used to block 5-HT(1A) receptors. Systemic administration of SB 258741 significantly reduced the effect of combined selective serotonin reuptake inhibitor and WAY 100.635 administration on extracellular 5-HT in the ventral hippocampus as well as 5-HT neuronal firing in the dorsal raphe nucleus. In the microdialysis study, co-administration of AS19 and WAY 100.635 showed a biphasic effect on extracellular 5-HT in ventral hippocampus, hinting at opposed 5-HT(7) receptor mediated effects. In the electrophysiological experiments, systemic administration of AS19 alone displayed a bell-shaped dose-effect curve: moderately increasing 5-HT neuronal firing at lower doses while decreasing it at higher doses. SB 258741 was capable of blocking the effect of AS19 at a low dose. This is consistent with the pharmacological profile of AS19, displaying high affinity for 5-HT(7) receptors and moderate affinity for 5-HT(1A) receptors. The data are in support of an excitatory effect of selective serotonin reuptake inhibitors on 5-HT neuronal activity mediated by 5-HT(7) receptors. It can be speculated, that the restoration of 5-HT neuronal firing upon chronic antidepressant treatment, which is generally attributed to desensitization of 5-HT(1A) receptors alone, in fact results from a shift in balance between 5-HT(1A) and 5-HT(7) receptor function.
A PG-LSH Similarity Search Method for Cloud Storage (2013)

LSH (Locality Sensitive Hashing) indexing is often used for similarity search in high-dimensional object set. The way of separating index and store in LSH is particularly suitable for searching encrypted data stored in the cloud. However, most LSH methods only use or improve the first phase of LSH for similarity search. In this paper, we focus on the second phase of LSH, and propose a probability guarantee LSH (PG-LSH) method based on the Multi-Probe method, and apply it to cloud storage encrypted data search. Our approach simplifies the candidate set generation process and removes pseudo-similar objects. Experimental results show that the elimination rate of PG-LSH is more than 21%. It can also effectively reduce the time and space without losing search quality.
A 1–18-Ghz attenuator calibrator (1976)

This single-channel parallel IF substitution system performs attenuator calibrations in a stepped frequency mode to 110 dB through 1–18 GHz, with the accuracy of a fixed frequency system. Measurement time is reduced and operation is simplified by use of two digitally controlled, frequency-locked oscillators as signal source and local oscillator, a 30-MHz precision digital substitution standard and an adaptive bandwidth closed-loop substitution technique. Incident power and source impedance at the insertion point are established by a precision broad-band power splitter and a leveling loop using a barretter as the microwave detector. The load impedance is established by a low mismatch masking attenuator. Measurement sequences can be controlled manually or by a programmable calculator which processes the data. The IF substitution process when under calculator control is terminated when a signal buried in the noise is recovered and the servo-loop is balanced.
A Total Population Study of Diagnosed Chromosome Abnormalities in Queensland, Australia (1983)

BELL, J.; PEARN, J.; McCARTHY, C.; JONES, L.; TROUTON, C.; HUNT, F.; BERRY, L. Author Information
Effects of Calcium and Dairy on Body Composition and Weight Loss in African‐American Adults (2005)

Substitution of calcium-rich foods in isocaloric diets reduced adiposity and improved metabolic profiles in obese African Americans without energy restriction or weight loss and augmented weight and fat loss secondary to energy restriction.
EEG, HRV and Psychological Correlates while Playing Bejeweled II: A Randomized Controlled Study. (2009)

Stress related medical disorders such as cardiovascular disease, diabetes, depression, and anxiety are serious medical issues that can cause disability and death. Interventions to prevent their development and exacerbation are needed. Casual video games (CVGs) are fun, easy to play, spontaneous and tremendously popular. People report that they play these games because they decrease their stress and improve their mood. This study tested this theory by comparing people playing Bejeweled II a popular CVG with control subjects measured under similar conditions. Electroencephalographic (EEG) changes after playing Bejeweled II were consistent with increased mood and corroborated with similar findings on psychological reports. Moreover, heart rate variability (HRV) changes consistent with autonomic nervous system relaxation or decreased physical stress were also recorded. It is concluded, therefore, that playing a CVG like Bejeweled II can increase mood and decrease stress. These finding have broad implications and include the potential development of prescriptive interventions using Bejeweled II to prevent and treat stress related medical disorders. Finally, these findings demonstrate a method using EEG, HRV and psychological correlates to understand the psychophysiological or cybernetic interconnection between participant and video game.
The characteristics of binding of human recombinant interferon-<i>gamma</i> to its receptor on human monocytes and human monocyte-like cell lines. (1985)

Interferon-gamma (IFN-gamma) induces many effector functions in macrophages, presumably through binding to cell surface receptors. Such receptors have been documented in murine macrophages. This report demonstrates that IFN-gamma interacts with a specific receptor on human monocytes and monocyte-like cell lines, U937 and HL60. Recombinant IFN-gamma (rIFN-gamma) was radioiodinated by using Bolton-Hunter reagent to high specific activity. 125I-rIFN-gamma bound in a specific and saturable manner. Saturation of binding sites occurred at 10(-9) M (300 U/ml); there were 4000 specific binding sites per cell for both monocytes and the cell lines. Purified lymphocyte-derived IFN-gamma as well as rIFN-gamma competed for binding sites with 125I-rIFN-gamma. There was no inhibition of binding of the 125I-rIFN-gamma by rIFN-alpha or rIFN-beta. The forward rate constant, k1, at 4 degrees C was about 8 X 10(5) M-1 sec-1 for each cell type studied. In the presence of excess ligand, the dissociation rate constant, k-1, was about 2 X 10(-4) sec-1. The Ka calculated from these constants (4 X 10(9) M-1) agreed closely with that calculated from experiments performed at equilibrium (8 X 10(9) M-1). Because the dissociation of rIFN-gamma from cells was enhanced in the presence of ligand, interactions between binding sites of a negative cooperative type could be operative. These studies demonstrate that rIFN-gamma binds in a specific and saturable manner and with high affinity to a receptor on human monocytes as well as monocyte-like cell lines.
Immunotherapy of HSV infections – antibody delivery (2007)

Passive immunization involves utilizing polyclonal or monoclonal antibodies as a form of immunotherapy. Antibodies can mediate their effects through several mechanisms, including opsonization and C-mediated lysis, but in particular antibody-dependent cell-mediated cytolysis (ADCC) and neutralization. Antibody immunotherapy has been demonstrated to be efficacious for the treatment and prevention of infection or disease caused by viruses other than herpes simplex virus (HSV) (Abzug et al., 1995; Reed et al., 1988; Feltes et al., 2003; Saez-Llorens et al., 1998; Subramanian et al., 1998; The IMpact-RSV Study Group, 1998). While intriguing data exist in animal models suggesting that such a therapeutic intervention may also be of benefit in the management of HSV infections, to date no controlled studies have demonstrated the benefit of such an approach in humans. This chapter explores the potential of such an approach in people, as well as the limitations in current knowledge.
Purification and catalytic properties of Ech hydrogenase from <i>Methanosarcina barkeri</i> (1999)

Methanosarcina barkeri has recently been shown to produce a multisubunit membrane-bound [NiFe] hydrogenase designated Ech (Escherichia coli hydrogenase 3) hydrogenase. In the present study Ech hydrogenase was purified to apparent homogeneity in a high yield. The enzyme preparation obtained only contained the six polypeptides which had previously been shown to be encoded by the ech operon. The purified enzyme was found to contain 0.9 mol of Ni, 11.3 mol of nonheme-iron and 10.8 mol of acid-labile sulfur per mol of enzyme. Using the purified enzyme the kinetic parameters were determined. The enzyme catalyzed the H2 dependent reduction of a M. barkeri 2[4Fe-4S] ferredoxin with a specific activity of 50 U x mg protein-1 at pH 7.0 and exhibited an apparent Km for the ferredoxin of 1 microM. The enzyme also catalyzed hydrogen formation with the reduced ferredoxin as electron donor at a rate of 90 U x mg protein-1 at pH 7.0. The apparent Km for the reduced ferredoxin was 7.5 microM. Reduction or oxidation of the ferredoxin proceeded at similar rates as the reduction or oxidation of oxidized or reduced methylviologen, respectively. The apparent Km for H2 was 5 microM. The kinetic data strongly indicate that the ferredoxin is the physiological electron donor or acceptor of Ech hydrogenase. Ech hydrogenase amounts to about 3% of the total cell protein in acetate-grown, methanol-grown or H2/CO2-grown cells of M. barkeri, as calculated from quantitative Western blot experiments. The function of Ech hydrogenase is ascribed to ferredoxin-linked H2 production coupled to the oxidation of the carbonyl-group of acetyl-CoA to CO2 during growth on acetate, and to ferredoxin-linked H2 uptake coupled to the reduction of CO2 to the redox state of CO during growth on H2/CO2 or methanol.
CHEAP AND CHEERFUL (2001)

Fastenal's strategy is to pinch every penny twice before letting it go. So far, it's working.
The Judiciary and the Academy: A Fraught Relationship (2010)

I have been a federal court of appeals judge since 1981, and before that I had been a full-time law professor since 1968.And since becoming ajudge I have continued to teach part time and do academic research and writing.The United States is unusual if not quite unique in the porousness of the membranes that separate the different branches of the legal profession.The judiciary both federal and state is a lateral-entry institution rather than a conventional civil service; and unlike the British system (though that system is loosening up and becoming more like the U.S. system), in which the judges are drawn from a narrow, homogeneous slice of the legal profession -namely, senior barristers -American judges are drawn from all the different branches of the profession, including the academic.Among appellate judges who came to the bench from academia are
Enhanced semantic priming in schizophrenia: a computer model based on excessive pruning of local connections in association cortex (2002)

This study suggests that schizophrenia arises from excessive pruning of local connections in association cortex. Its findings shed light on the mechanisms underlying cognitive priming more generally, and how it might emerge developmentally.
Optic Nerve Damage in Experimental Mouse Ocular Hypertension (2003)

Laser-induced ocular hypertension in mouse eyes can induce optic nerve axon loss that correlates with the magnitude and duration of elevated IOP.
Isolation and Characterization of a <i>Mycobacterium</i> Species Capable of Degrading Three- and Four-Ring Aromatic and Aliphatic Hydrocarbons (1999)

Mycobacterium sp. strain CH1 was isolated from polycyclic aromatic hydrocarbon (PAH)-contaminated freshwater sediments and identified by analysis of 16S rDNA sequences. Strain CH1 was capable of mineralizing three- and four-ring PAHs including phenanthrene, pyrene, and fluoranthene. In addition, strain CH1 could utilize phenanthrene or pyrene as a sole carbon and energy source. A lag phase of at least 3 days was observed during pyrene mineralization. This lag phase decreased to less than 1 day when strain CH1 was grown in the presence of phenanthrene or fluoranthene. Strain CH1 also was capable of using a wide range of alkanes as sole carbon and energy sources. No DNA hybridization was detected with the nahAc gene probe, indicating that enzymes involved in PAH metabolism are not related to the well-characterized naphthalene dioxygenase gene. DNA hybridization was not detected when the alkB gene from Pseudomonas oleovorans was used under high-stringency conditions. However, there was slight but detectable hybridization under low-stringency conditions. This suggests a distant relationship between genes involved in alkane oxidation.
A 55μW 93.1dB-DR 20kHz-BW single-bit CT ΔΣ modulator with negative R-assisted integrator achieving 178.7dB FoM in 65nm CMOS (2017)

This paper presents a 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> order single-bit CT ΔΣ modulator with active-RC integrators using negative-R assistant at virtual ground, which mitigates opamp's requirements including the thermal noise and linearity leading to a drastic power-saving. Fabricated in a 65nm CMOS process, the modulator occupies area of 0.27mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . It achieves 100.5dB SFDR and 93.1dB DR in 20kHz BW, while consuming only 55μW from a 1.2V supply. This results in Schreier FoM of 178.7dB and Walden FoM of 63.1fJ/step.
Impact of trust, security and privacy concerns in social networking: An exploratory study to understand the pattern of information revelation in Facebook (2013)

In the era of Internet technologies, social networking websites has witnessed thriving popularity. Computer mediated communication has changed the rules of social interaction and communication. Most social networking sites like Orkut, Facebook, Google+, Twitter etc. facilitates user's with the features like online interaction, sharing of information and developing new relationships etc. Online interaction and sharing of personal information in social networking sites has raised new privacy concerns. So, it requires an exploratory insight into user's behavioural intention to share information. This research aims to develop a research model, with security and privacy concerns conceptualized as an antecedent of trust in social networking site and moderator of information sharing. The study aims to understand the impact of security, trust and privacy concerns on the willingness of sharing information in social networking sites.
Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma (2010)

Romidepsin may be an effective therapeutic option for patients with CTCL who have had treatment failure with multiple standard treatment modalities.
Secretory Component‐Binding Properties of Normal Serum IgM (1990)

Our aim was to investigate why serum IgM is poorly transferred into secretions in normal subjects. Indeed, the low IgM level in secretions contrasts with the capacity of monoclonal IgM to bind to secretory component (SC), but it is not well established to what extent normal serum IgM can do so. The mean SC affinity was studied with a polyclonal IgM preparation from 250 normal subjects and with a representative pool of 100 different monoclonal IgM. The SC-binding percentages varied as a function of the IgM/SC molar ratio according to a common hyperbolic curve, with similar association constants: Ka = 4.19 +/- 2.61 x 10(7) M-1 (polyclonal pool) and Ka = 5.80 +/- 2.73 x 10(7) (monoclonal pool). It thus appears that the large difference in IgM concentrations between blood and secretions cannot be due to an SC-binding defect of serum IgM, but is probably explained by its low diffusion from blood to the extravascular compartment.
TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT (2013)

Leucine-rich repeat kinase 2 (LRRK2) mutation is the most common cause of genetic-related parkinsonism and is usually associated with Lewy body pathology; however, tau, α-synuclein, and ubiquitin pathologies have also been reported. We report the case of a patient carrying the LRRK2 G2019S mutation and a novel heterozygous variant c.370C>G, p.Q124E in exon 4 of the microtubule-associated protein tau (MAPT). The patient developed parkinsonism with good levodopa response in her 70s. Neuropathological analysis revealed nigral degeneration and Alzheimer-type tau pathology without Lewy bodies. Immunohistochemical staining using phospho-TDP-43 antibodies identified occasional TDP-43 pathology in the hippocampus, temporal neocortex, striatum, and substantia nigra. However, TDP-43 pathology was not identified in another 4 archival LRRK2 G2019S cases with Lewy body pathology available in the Queen Square Brain Bank. Among other published cases of patients carrying LRRK2 G2019S mutation, only 3 were reportedly evaluated for TDP-43 pathology, and the results were negative. The role of the MAPT variant in the clinical and pathological manifestation in LRRK2 cases remains to be determined.
Dual Electrode Thalamic Deep Brain Stimulation For The Treatment Of Posttraumatic And Multiple Sclerosis Tremor (2006)

Tremors, such as those examined in this study, that are refractory to medications and have a poor response to VIM DBS monotherapy, may respond favorably to VIM plus VOA/VOP DBS. Two electrodes may be better than one for the treatment of certain disorders; however, more study will be required to confirm this hypothesis.
Preparation and Biological Activity of Amino Acid and Peptide Conjugates of Antitumor Hydroxymethylacylfulvene (2000)

The primary hydroxyl group in hydroxymethylacylfulvene, a potent antitumor drug, is readily replaced by thiols including cysteine, N-acetylcysteine, homocysteine, and glutathione. Best yields are obtained when reaction is carried out in the presence of dilute sulfuric acid. A variety of sulfur-containing analogues have been prepared, and their toxicity to tumor cells was examined.