gebhart/patrepeval huggingface dataset:
The Vibration of Rectangular Plates (1954)

In this paper are considered the free transverse vibrations of rectangular plates with all possible boundary conditions obtained by combining free, freely-supported, and fixed edges. The Rayleigh method, assuming waveforms similar to those of beams, is used to derive a simple approximate frequency expression for all modes of vibration. The terms in this expression depend on the nodal pattern and the boundary conditions; they are tabulated for fifteen boundary conditions—all four edges free, freely-supported, or fixed and the twelve cases in which some of the edges have one condition and the rest another. The expression can also be used to obtain frequencies for a plate which has a combination of all three boundary conditions. The effect on frequency of an edge being supported and partially restrained is discussed. For some boundary conditions it is possible to compare derived frequencies with those obtained by various methods of accurate analysis and by experiment; except for a few cases, the results from the approximate expression and accurate analysis agree closely. For rectangular plates and for most boundary conditions and modes of square plates, the nodal pattern consists of lines approximately parallel to the sides of the plate. The exceptions are discussed and the gradual transition from these non-parallel patterns characteristic of a square plate to those of a rectangular plate is traced. The frequencies of extensional vibrations of rectangular plates are derived for two boundary conditions.
Gesture recognition using depth-based hand tracking for contactless controller application (2012)

This paper proposes a gesture recognition system capable of providing a contactless controller via depth-based hand tracking. Main proposal is a hand tracking algorithm in depth image by calculating a hand weighted probability. An implementation of the proposed system into a contactless controller application demonstrated its effectiveness.
<b>OptimalCutpoints</b>: An<i>R</i>Package for Selecting Optimal Cutpoints in Diagnostic Tests (2014)

Continuous diagnostic tests are often used for discriminating between healthy and diseased populations. For the clinical application of such tests, it is useful to select a cutpoint or discrimination value c that defines positive and negative test results. In general, individuals with a diagnostic test value of c or higher are classified as diseased. Several search strategies have been proposed for choosing optimal cutpoints in diagnostic tests, depending on the underlying reason for this choice. This paper introduces an R package, known as OptimalCutpoints, for selecting optimal cutpoints in diagnostic tests. It incorporates criteria that take the costs of the different diagnostic decisions into account, as well as the prevalence of the target disease and several methods based on measures of diagnostic test accuracy. Moreover, it enables optimal levels to be calculated according to levels of given (categorical) covariates. While the numerical output includes the optimal cutpoint values and associated accuracy measures with their confidence intervals, the graphical output includes the receiver operating characteristic (ROC) and predictive ROC curves. An illustration of the use of OptimalCutpoints is provided, using a real biomedical dataset.
Human Resources Policies and Practices for Advancing Women in Canadian Organisations(1) (1993)

During the past twenty years there has been a dramatic increase in the number of women who are pursuing managerial and professional careers. Many of these women have prepared themselves for careers by undertaking university education in professional schools such as business, accountancy and law. Women are gaining the necessary experience and paying their dues. Despite these academic credentials, and increased experience, women are failing to move into the ranks of senior management (Burke & McKenn, 1992). This pattern has been observed in both public and private sector organisations in all developed countries (Adler & Israeli, 1988; Morrison & Von Glinow, 1990).
Multivalent Presentation of Mannose on Hyperbranched Polyglycerol and their Interaction with Concanavalin A Lectin (2011)

We describe the synthesis of multivalent mannose derivatives by using hyperbranched polyglycerols (hPG) as a scaffold with different linker structures. Grafting of protected mannose (Man) units is achieved by using Cu(I) -catalyzed Huisgen click chemistry with either an anomeric azide or propargyl ether onto complementarily functionalized alkyne or azido polymer surfaces. NMR spectroscopy, dynamic light scattering (DLS), IR spectroscopy, size-exclusion chromatography (SEC), and elemental analysis have been used to characterize the hPG-Man compounds. The surface availability and bioactivity of Man-modified polymers were evaluated by using a competitive surface plasmon resonance (SPR)-based binding assay by interactions of the glycopolymers with concanavalin A (Con A), a lectin that binds mannose containing molecules. The results indicated that the novel glycoarchitectures presented in this work are efficient inhibitors of Con A-mannose recognition and resulted in inhibitor concentrations (mean IC(50)) from the micro- to the nanomolar range, whereas the corresponding monovalent mannoside (methyl-Man) requires millimolar concentrations. The results provide an interesting structure-activity relationship for libraries of materials that differ in the linkage of the sugar moiety presented on a biocompatible polyglycerol scaffold.
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria (2018)

Individuals with sporadic colorectal cancer (CRC) frequently harbor abnormalities in the composition of the gut microbiome; however, the microbiota associated with precancerous lesions in hereditary CRC remains largely unknown. We studied colonic mucosa of patients with familial adenomatous polyposis (FAP), who develop benign precursor lesions (polyps) early in life. We identified patchy bacterial biofilms composed predominately of <i>Escherichia coli</i> and <i>Bacteroides fragilis</i> Genes for colibactin (<i>clbB</i>) and <i>Bacteroides fragilis</i> toxin (<i>bft</i>), encoding secreted oncotoxins, were highly enriched in FAP patients' colonic mucosa compared to healthy individuals. Tumor-prone mice cocolonized with <i>E. coli</i> (expressing colibactin), and enterotoxigenic <i>B. fragilis</i> showed increased interleukin-17 in the colon and DNA damage in colonic epithelium with faster tumor onset and greater mortality, compared to mice with either bacterial strain alone. These data suggest an unexpected link between early neoplasia of the colon and tumorigenic bacteria.
Research of braking mode of permanent magnet brushless motors without special brake devices (2014)

A subject of this paper is an automatic braking method of the permanent magnet brushless motors (PMBD) equipped with a two-stage frequency converter without special brake devices. The most important feature of the PMBD is an ability to control the position of stator current vector relative to the position of motor rotor field vector. An automatic voltage controller when braking limits the DC-link capacitor voltage to the safe level by the direct stator current component increase. Thus, the surplus of braking power is dissipated in motor stator windings. The proposed braking control approach minimizes the hardware of electric drives. Computation example of automatic braking process characteristics is given.
Improving the timing jitter of a superconducting nanowire single-photon detection system (2017)

Low timing jitter is a unique merit of superconducting nanowire single-photon detectors (SNSPDs) for time-correlated applications. Quantitative analysis was performed for the SNSPD system. Aided by an oscilloscope with an optimal signal amplitude, we were able to measure a full width at half-maximum system timing jitter as low as 14.2 ps for a high-switching-current SNSPD using a room-temperature low-noise amplifier. When using a time-correlated single-photon counting module, the system timing jitter was 17.3 ps. The detector’s intrinsic timing jitter was estimated at ∼12.0  ps.
Low power damping control of a resonant sensor using back action in silicon nanowires (2016)

This paper reports the damping control of a MEMS resonator, vibrating at several kilohertz, using tiny p-doped piezoresistive silicon nanowires (SiNW). Due to thermal piezoresistive back action (TPBA), DC-current biasing of the nanobeams induces a strong increase of the damping rate, about 2 decades above the intrinsic damping rate of the resonator. Intrinsic quality factor (QF) around 3.104 is here reduced to 450 thanks to an outstanding efficient TPBA. It is worth noting that QF can be here finely controlled for DC-current as low as a few tens μA, which leads to very low power consumption at constant voltage generator circuitry. This property is highly suitable for numerous applications, such as amplitude modulated resonant sensors (gyrometers, accelerometers...) or high performance resonant sensors, for which an accurate and repeatable control of the QF is required. Furthermore, the proposed mechanism allows bandwidth tuning and temperature compensation of the QF, without inducing parasitic crosstalk signals.
Interaction of silver nitrate with readily identifiable groups: relationship to the antibacterialaction of silver ions (1997)

Microbiologically it was demonstrated that amino acids, e.g. cysteine (CySH), and other compounds, e.g. sodium thioglycollate, containing thiol groups neutralized the activity of silver nitrate against Pseudomonas aeruginosa PAO1. Amino acids with disulphide bonds were inactive, with the exception of L-cystine dimethyl ester, as were all amino acids with no sulphur groups. Iodoacetamide reacted with CySH to produce a CyS-acetamide complex that was unable to quench the activity of Ag+. Chemical analyses using cyclic voltammetry demonstrated that high coordination numbers (3.1) were obtained with thiol-containing amino acids and low numbers (0.28-0.4) with other amino acids. Both microbiologically and chemically, the results imply that interaction of Ag+ with thiol groups plays an essential role in bacterial inactivation.
Organic Microcavity Photodiodes (2003)

Abstract The interaction of light and matter lies at the heart of the principle of optoelectronic devices. By tuning the strength of the electric field component of the light wave, one can gain control over this interaction. A simple way of achieving this is by employing microcavities, which are one‐dimensional photonic structures. These give rise to an effective quantization of the light field in one direction. The largest enhancements in the strength of light–matter coupling are achieved for cavities with dimensions on the order of the effective wavelength of light. As organic materials have the very large oscillator strengths required for light–matter coupling, as well as excellent thin film forming properties, they are ideal materials with which to exploit tunable electron–photon coupling. We demonstrate the influence of the optical field strength in organic microcavity photodiodes. Besides allowing tunability of the response spectrum by varying the effective resonator thickness, a large increase in the photocurrent sensitivity is observed below the absorption threshold of the optically active material. The microcavity induced field enhancement plays a particularly important role under two‐photon excitation. In this case we observe a 500‐fold increase in the photocurrent response with respect to a non‐cavity device. This opens up a range of applications for organic microcavity photodiodes as nonlinear detector elements.
Cognitive, Extrapyramidal, and Magnetic Resonance Imaging Predictors of Functional Impairment in Nondemented Older Community Dwellers: The Sydney Older Person Study (2005)

This study has shown that many nondemented very old people living in the community are losing capacity to perform IADL functions and that areas of incapacity are associated with the presence of EP signs and impaired cognition. These results highlight the need for health workers to include an assessment of EP and cognitive status in their evaluation of older persons living in the community, even in the context of a lack of dementia diagnosis. Furthermore, it signifies the need to directly evaluate IADL function to identify need for intervention and support if required. This group of old-old individuals may now be considered the "survivors" of their cohort, and early detection of the difficulties they are experiencing will enable clinicians to respond appropriately, thus providing them a higher quality of life for their years to come.
Biologic Characteristics of a Continuous Kidney Cell Line Derived from the African Green Monkey (1963)

Discussion and Summary A continuous cell line derived from kidney tissue of the African green monkey, Cercopithecus aethiops and designated BS-C-1, has been maintained through 142 subcultures. Cultures of the BS-C-1 line support the growth of simian virus 40 to the same extent as do primary Cercopithecus kidney cell cultures; moreover, the pathognomonic vacuolating changes induced by this virus are as apparent in the continuous cell line as in the primary cell cultures. The BS-C-1 cell cultures are suitable for propagating several viruses, including polio, measles, Rift Valley fever, respiratory syncytial, Coxsackie A9, O'Malley's A-1 agent, and simian agents 1, 4 and 5. In contrast, several strains of influenza A and B viruses and of adenoviruses 3, 4 and 7 as well as simian virus 2 failed to multiply in BS-C-1 cells. No change in the susceptibility of the BS-C-1 cultures of SV40 virus was detected throughout 142 passages of the cell line. On the other hand, during this period of culture the cell line changed its chromosomal characteristics. Thus, the pattern remained diploid, i.e., 60 chromosomes, beyond the 20th subculture, and became subdiploid by the 41st passage after which it continued to change its characteristics with a majority of the cells in the 52nd passage having 59 chromosomes and the remainder 58; most of the cells had a dicentric chromosome. By the 111th passage, most of the cells approached the hypotetraploid state with 83% of the cells having 114 to 117 chromosomes. To our knowledge, this represents the first instance in which continuous observations have been made on the susceptibility of a tissue culture cell system to a given virus during a period when its cells changed from the diploid to the polyploid state. In this particular system the changes in chromosomal pattern were not associated with change in susceptibility to the virus. The BS-C-1 line is apparently free of extraneous microbial agents; seed cultures can be maintained in the frozen state; it grows rapidly and is not fastidious in its nutritional requirements. The BS-C-1 continuous cell line provides the virologist with another tool for diagnostic and research work and perhaps for the large scale cultivation of viral agents for vaccines. As regards the last mentioned possibility the employment of continuous cell lines has recently received a cautious endorsement (22) for use in carefully planned, progressively expanding studies.
Prolactin stimulates cell proliferation through a long form of prolactin receptor and K+ channel activation (2004)

PRL (prolactin) has been implicated in the proliferation and differentiation of numerous tissues, including the prostate gland. However, the PRL-R (PRL receptor) signal transduction pathway, leading to the stimulation of cell proliferation, remains unclear and has yet to be mapped. The present study was undertaken to develop a clear understanding of the mechanisms involved in this pathway and, in particular, to determine the role of K(+) channels. We used androgen-sensitive prostate cancer (LNCaP) cells whose proliferation is known to be stimulated by PRL. Reverse transcriptase PCR analysis showed that LNCaP cells express a long form of PRL-R, but do not produce its intermediate isoform. Patch-clamp techniques showed that the application of 5 nM PRL increased both the macroscopic K(+) current amplitude and the single K(+)-channel open probability. This single-channel activity increase was reduced by the tyrosine kinase inhibitors genistein, herbimycin A and lavandustine A, thereby indicating that tyrosine kinase phosphorylation is required in PRL-induced K(+) channel stimulation. PRL enhances p59( fyn ) phosphorylation by a factor of 2 after a 10 min application in culture. In addition, where an antip59( fyn ) antibody is present in the patch pipette, PRL no longer increases K(+) current amplitude. Furthermore, the PRL-stimulated proliferation is inhibited by the K(+) channel inhibitors alpha-dendrotoxin and tetraethylammonium. Thus, as K(+) channels are known to be involved in LNCaP cell proliferation, we suggest that K(+) channel modulation by PRL, via p59( fyn ) pathway, is the primary ionic event in PRL signal transduction, triggering cell proliferation.
A 1 V DSP for wireless communications (2002)

Modern cellular phones are placing increasingly stringent demands on battery life and, therefore, on the power dissipation of the embedded DSP circuitry. At the same time, greater computational throughput is being required of the DSP, for example to implement more sophisticated speech and channel coding algorithms. Earlier low-power DSPs were reported. However, further improvements in power and performance are required. This paper describes a full-function, 1.6M-transistor, fixed-point programmable DSP designed for wireless communication applications to address these dual constraints of lower power and higher throughput. This is achieved by operating at 1V and using a dual-V process to maintain high performance.
Recent Patents on Anti-Telomerase Cancer Therapy (2011)

Telomerase, a specialised RNA-directed DNA polymerase extends and stabilises the telomeres at the ends of the eukaryotic chromosomes. The progressive loss of telomeres results in limited number of cell divisions and has been linked to the mechanism of human cellular ageing. Tumour cells marked by indefinite proliferation have stable telomere length maintained by telomerase. The differential expression of the telomerase enzyme in normal and cancer cells have led to the evolution of tumour specific anti-telomerase approaches which inhibit the telomerase enzyme activity so as to destabilise and shorten the telomeres leading to senescence in cancer cells. In the current review, we have selected nine tumour specific anti-telomerase approaches based on their mechanism of action or the target components of the human telomerase enzyme: Antisense-oligonucleotides, hammerhead ribozymes, dominant negative hTERT, reverse-transcriptase inhibitors, immunotherapy, G-quadruplex stabilisers, gene therapy, small molecule inhibitors and RNA interference. Recent research developments for each of the anti-telomerase approaches with the detailed analysis of specific granted patents from the perspective of different claims and downstream applications have been provided. A comprehensive list of patents for the different anti-telomerase approaches which includes information regarding the authors and institutional ownership along with the year of issue of the patent has also been provided.
The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases (2016)

Olfactory deficits are present in numerous neurodegenerative disorders and are accompanied by pathology in related brain regions. In several of these disorders, olfactory disturbances appear early and are considered as prodromal symptoms of the disease. In addition, pathological protein aggregates affect olfactory regions prior to other regions, suggesting that the olfactory system might be particularly vulnerable to neurodegenerative diseases. Exposed to the external environment, the olfactory epithelium and olfactory bulb allow pathogen and toxin penetration into the brain, a process that has been proposed to play a role in neurodegenerative diseases. Determining whether the olfactory bulb could be a starting point of pathology and of pathology spread is crucial to understanding how neurodegenerative diseases evolve. We argue that pathological changes following environmental insults contribute to the initiation of protein aggregation in the olfactory bulb, which then triggers the spread of the pathology within the brain by a templating mechanism in a prion-like manner. We review the evidence for the early involvement of olfactory structures in neurodegenerative diseases and the relationship between neuropathology and olfactory function. We discuss the vulnerability and putative underlying mechanisms by which pathology could be initiated in the olfactory bulb, from the entry of pathogens (promoted by increased permeability of the olfactory epithelium with aging or inflammation) to the sensitivity of the olfactory system to oxidative stress and inflammation. Finally, we review changes in protein expression and neural excitability triggered by pathogenic proteins that can promote pathogenesis in the olfactory bulb and beyond.
A method to predict the Raman gain spectra of germanosilicate fibers with arbitrary index profiles (2002)

In this letter, we present a technique for calculating the Raman gain spectra of germanosilicate fibers from their index profiles. The gain spectra depend on radial profiles of the guided optical modes and the glass composition, in particular the distribution of Si-O-Si and Ge-O-Si bridging bonds. We have obtained spectral coefficients, which represent the contributions from these bonds using Raman gain measurements made on a set of calibration fibers with well-characterized index profiles. We describe how these spectral coefficients can be used in the design of Raman gain fibers, and we demonstrate the accuracy of our technique over a broad range of fiber types.
Inverse relationship between the titre of TT virus DNA and the CD4 cell count in patients infected with HIV (2001)

TTV is highly prevalent and high-titred in HIV-infected patients. The TTV viral load may reflect the degree of immune status of these immunocompromised hosts.
Solution processed transition metal sulfides: application as counter electrodes in dye sensitized solar cells (DSCs) (2011)

A solution processed method for fabricating transition metal sulfides on fluorine doped tin oxide (FTO) as efficient counter electrodes in iodine/iodide based solar cells has been demonstrated. Conversion efficiencies of 7.01% and 6.50% were obtained for nickel and cobalt sulfides, respectively, comparable to the conventional thermally platinised FTO electrodes (7.32%). A comparable charge transfer resistance of Ni(3)S(2) and Co(8.4)S(8) to conventional Pt was found to be a key factor for such high efficiencies. Cyclic voltammetry, Kelvin probe microscopy, Electrochemical Impedance Spectroscopy, and Tafel polarization were performed to study the underlying reasons behind such efficient counter electrode performance.