gebhart/patrepeval huggingface dataset:
Mutual coupling and sidelobe tapers in phase-only antenna synthesis for linear and planar arrays (1988)

A method of obtaining the lowest possible peak sidelobe levels, given a specified sidelobe envelope, by phase-only variation of the generator phases is presented. A generalization of earlier work by the authors, this technique involves the optimization of a piecewise differentiable objective function using the method of steepest descent to obtain desired generator phases, given prescribed excitation magnitudes. The method has been applied to both linear and planar arrays of radiators, with single-mode mutual coupling effects included to provide realistic data. Values for the various array performance indices are presented, and results indicate that introduction of sidelobe taper improves the array gain while raising the peak sidelobe level somewhat. Inclusion of mutual coupling effects alters the required phases for optimum patterns but does not significantly affect the performance indices of the array.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An Efficient Mammalian Transfer RNA Target for Bleomycin (2006)

The antitumor antibiotic bleomycin has long been believed to exert its therapeutic effects at the level of DNA cleavage. Recently, evidence has been presented to suggest that RNA cleavage may also be important and that one or more transfer RNAs may be involved. To define those tRNAs that may represent important loci for the action of bleomycin, we have fractionated chicken liver tRNAs and identified those isoacceptors most susceptible to oxidative cleavage by Fe(II).BLM. Two chicken liver tRNAs, tRNA3Lys and tRNAPhe, were found to be cleaved with exceptional facility by Fe(II).BLM, and both were cleaved predominantly at U66. The cleavage of tRNA3Lys was shown to be minimally affected by physiological concentrations of Mg2+. Chicken liver tRNA3Lys is identical in sequence with human tRNA3Lys. These findings support a possible role for a critical tRNA such as tRNA3Lys in the mechanism by which bleomycin mediates its antitumor activity.
Biocompatible, High Precision, Wideband, Improved Howland Current Source With Lead-Lag Compensation (2012)

The Howland current pump is a popular bioelectrical circuit, useful for delivering precise electrical currents. In applications requiring high precision delivery of alternating current to biological loads, the output impedance of the Howland is a critical figure of merit that limits the precision of the delivered current when the load changes. We explain the minimum operational amplifier requirements to meet a target precision over a wide bandwidth. We also discuss effective compensation strategies for achieving stability without sacrificing high frequency output impedance. A current source suitable for Electrical Impedance Tomography (EIT) was simulated using a SPICE model, and built to verify stable operation. This current source design had stable output impedance of 3.3 MΩ up to 200 kHz, which provides 80 dB precision for our EIT application. We conclude by noting the difficulty in measuring the output impedance, and advise verifying the plausibility of measurements against theoretical limitations.
Training down under: An Overview of the Australian Experience (1994)

Examines the extent and coverage of private‐sector training in Australia and offers an overview of recent Australian Government initiatives in vocational education and training. Argues that Australia′s system of industrial relations diminishes the potential for training at the workplace but suggests that recent changes in institutional arrangements may mitigate this. Indicates that the introduction of a compulsory uniform training levy has not been very successful.
Diensynthesen mit Dichlorvinylencarbonat (1972)

Abstract Unter Normaldruck verlaufende Diensynthesen des relativ schwach dienophilen Dichlorvinylencarbonats (DCVC) ( 1 ) mit Cyclopentadien, Cyclohexadien‐(1.3), Anthracen, 9.10‐Dimethyl‐anthracen und 2.3‐Dimethyl‐butadien sowie die Solvolyse dieser Addukte ( 2, 4 – 6 ) werden beschrieben. Die Hydrolyse der Addukte cyclischer Diene macht bicyclische β,γ‐ungesättigte 1.2‐Diketone ( 7, 20 ) zugänglich.
The howard savings institution - A case history in real-time data processing (1963)

Nine years ago, in 1953, The Howard Savings Institution of Newark, N. J., launched a research study into automation. Today, Howard Savings Institution customers are enjoying the benefits of the fastest, most accurate savings accounting system in the world. This paper describes the customer benefits, the electronic data processing system that makes them possible, and the advantages and disadvantages of real-time data processing for the savings bank industry.
Automated Purification of His <sub>6</sub> -Tagged Proteins Allows Exhaustive Screening of Libraries Generated by Random Mutagenesis (2000)

In the course of site-directed mutagenesis or directed evolution experiments, large numbers of protein variants are often generated. To characterize functional properties of individual mutant proteins in vitro, a rapid and reliable protein purification system is required. We have developed an automated method for the parallel purification of 96 different protein variants that takes about two hours. Using a 96-well format, the whole process can be performed automatically by a pipetting robot. Coupled with a suitable assay, again using a 96-well format, all variants can be functionally characterized within a few hours. The protein purification procedure described here is based on the interaction between His6-tagged proteins and Ni-NTA-coated microplates. Typical yields are 3-8 pmol purified protein/well, which is sufficient to analyze most enzymatic activities. Using this procedure, we have purified and characterized variants of the restriction endonuclease EcoRV, which were produced in an effort to enhance the selectivity of this enzyme. For this purpose, three amino acid residues were randomized in a region known from the co-crystal structure to be located at the protein-DNA interface. From a library of about 1200 variants, predominantly single and double mutants, more than 1000 variants were purified and characterized in parallel, which corresponds to an almost complete screening of the library.
Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement (2019)

<b>Background:</b> Spirometry is the most common pulmonary function test. It is widely used in the assessment of lung function to provide objective information used in the diagnosis of lung diseases and monitoring lung health. In 2005, the American Thoracic Society and the European Respiratory Society jointly adopted technical standards for conducting spirometry. Improvements in instrumentation and computational capabilities, together with new research studies and enhanced quality assurance approaches, have led to the need to update the 2005 technical standards for spirometry to take full advantage of current technical capabilities.<b>Methods:</b> This spirometry technical standards document was developed by an international joint task force, appointed by the American Thoracic Society and the European Respiratory Society, with expertise in conducting and analyzing pulmonary function tests, laboratory quality assurance, and developing international standards. A comprehensive review of published evidence was performed. A patient survey was developed to capture patients' experiences.<b>Results:</b> Revisions to the 2005 technical standards for spirometry were made, including the addition of factors that were not previously considered. Evidence to support the revisions was cited when applicable. The experience and expertise of task force members were used to develop recommended best practices.<b>Conclusions:</b> Standards and consensus recommendations are presented for manufacturers, clinicians, operators, and researchers with the aims of increasing the accuracy, precision, and quality of spirometric measurements and improving the patient experience. A comprehensive guide to aid in the implementation of these standards was developed as an online supplement.
The<i>Bordetella bronchiseptica</i>Type III Secretion System Inhibits Gamma Interferon Production That Is Required for Efficient Antibody-Mediated Bacterial Clearance (2006)

Several species of pathogenic microorganisms have developed strategies to survive and persist in vital organs which are normally maintained as sterile by the generation of strong immune responses. Here, we report an immunomodulation involving the Bordetella bronchiseptica type III secretion system (TTSS) which contributes to bacterial survival in the lower respiratory tract of the host. The prolonged persistence of B. bronchiseptica that was observed in gamma interferon (IFN-gamma)-/- mice indicates that the efficient clearance of bacteria from the lower respiratory tract requires not only B cells and antibodies but also IFN-gamma production. Our data also suggest that interleukin-10 (IL-10)-producing splenocytes are generated early during infection and that IL-10 inhibits IFN-gamma-producing cells and delays the clearance of B. bronchiseptica from the lungs. The TTSS of B. bronchiseptica inhibits the generation of IFN-gamma-producing splenocytes and is required for long-term bacterial persistence in the lower respiratory tract in wild-type mice. This suggests that a mechanism involving the modulation of IFN-gamma production by the TTSS facilitates B. bronchiseptica survival in the lower respiratory tract.
Alkyl Esters of Phosphoric Acid (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkyl Esters of Phosphoric AcidCarroll A. Hochwalt, J. H. Lum, J. E. Malowan, and C. P. DyerCite this: Ind. Eng. Chem. 1942, 34, 1, 20–25Publication Date (Print):January 1, 1942Publication History Published online1 May 2002Published inissue 1 January 1942https://pubs.acs.org/doi/10.1021/ie50385a005https://doi.org/10.1021/ie50385a005research-articleACS PublicationsRequest reuse permissionsArticle Views1009Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Levosimendan Improves Exercise Performance in Patients with Advanced Chronic Heart Failure (2015)

Levosimendan treatment significantly improves peak VO<sub>2</sub> and reduces VE/VCO<sub>2</sub> slope and BNP in patients with ADHF.
Syntheses of Morpholine‐2,3‐diones and 2‐Hydroxymorpholin‐3‐ones: Intermediates in the Synthesis of Aprepitant. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Comparative physiology and fermentation performance of Saaz and Frohberg lager yeast strains and the parental species <i>Saccharomyces eubayanus</i> (2013)

Two distinct genetic groups (Saaz and Frohberg) exist within the hybrid Saccharomyces pastorianus (S. cerevisiae × S. eubayanus) taxon. However, physiological/technological differences that exist between the two groups are not known. Fermentative capability of the parental S. eubayanus has likewise never been studied. Here, 58 lager strains were screened to determine which hybrid group they belonged to, and selected strains were characterized to determine salient characteristics. In 15 °P all-malt wort fermentations at 22 °C, Frohberg strains showed greater growth and superior fermentation (80% apparent attenuation, 6.5% alcohol by volume in 3-4 days) compared to all other strains and maintained highest viability values (>93%). Fermentation with S. eubayanus was poor at the same temperature (33% apparent attenuation, 2.7% alcohol by volume at 6 days and viability reduced to 75%). Saaz strains and S. eubayanus were the least sensitive to cold (10 °C), though this did not translate to greater fermentation performance. Fermentation with S. eubayanus was poor at 10 °C but equal to or greater than that of the Saaz strains. Performance of Saaz yeast/S. eubayanus was limited by an inability to use wort maltotriose. [(14)C]-Maltotriose transport assays also showed negligible activity in these strains (≤0.5 µmol min(-1) g(-1) dry yeast). Beers from Saaz fermentations were characterized by two- to sixfold lower production of the flavour compounds methyl butanol, ethyl acetate and 3-methylbutyl acetate compared to Frohberg strains. Higher alcohol and ester production by S. eubayanus was similar to that of Frohberg strains.
Dantrolene Sodium Can Increase or Attenuate Activity of Skeletal Muscle Ryanodine Receptor Calcium Release Channel (1996)

The study results suggest that at least two binding sites for DS exist on the Ry1 receptor calcium channel. A low-affinity (microM) site is associated with reduced channel gating and open-state dwell time and may relate to the established pharmacologic muscle relaxant effect of DS. The proposed high-affinity (nM) DS binding site activates the channel, producing Ca2+ release to the myoplasm, which, under environmentally adverse conditions, could damage genetically predisposed MH muscle. Such a phenomenon, if it occurs in DS treated MH patients, could generate a recrudescence of the syndrome.
Immunological responses to fed protein antigens in mice. IV. Effects of stimulating the reticuloendothelial system on oral tolerance and intestinal immunity to ovalbumin. (1983)

We have studied the role of the reticuloendothelial system (RES) in intestinal and systemic immunity in mice immunized orally with ovalbumin (OVA). Stimulation of the RES by oestradiol completely prevented the induction of systemic tolerance normally found in mice fed 25 mg OVA and this applied both to humoral immunity and delayed-type hypersensitivity (DTH). In addition, an active DTH response could be detected in the mucosa and mesenteric lymph nodes (MLN) of oestradiol-treated, OVA-fed mice on oral challenge with OVA. Oestradiol had no direct effect on lymphocyte function and we propose that RES activation may be one mechanism which predisposes to small intestinal disease associated with food hypersensitivity.
Computer Vision Assisted Autonomous Intra-Row Weeder (2018)

Vegetable crop production is the rudimentary process for the sustainability of mankind on this planet. Technological advancements have been shaping the crop production in a commendable way nonetheless, weeds play a deleterious role for the growth of the crops. Weed management has hence become the alarming solution for increasing the yield. Even though manual weeding is being practiced by many nonetheless, labor costs, time and tedium have become the major constraints for the crop production. The introduction of the chemical methods of weed control has affected the growth of crops. However, the continuous use of herbicide-resistant weedicides has a serious impact on crops and the environment. So an increasing demand for chemical-free food has led to the investigation of alternative methods of weed control. Most of the methods of mechanical weeding doesn't produce the accurate result and moreover, existing intra-row weeders have limitations. This paper proposes the construction and working of an autonomous mechanical weeder. It consists of an actuator which is developed to mechanically remove intra-row weeds. The mechanically weeding actuator consists of an integrated servo motor which is combined with the computer vision assisted system for detecting the crop plant locations and guiding the weeding actuator to execute mechanical weeding operations without damaging the crops. The image extraction is based on a novel algorithm which effectively works with the encoding system of the robot movement with a precision of plus or minus 1cm. The accuracy of the system is found to be 96.3% using haar cascade classifier using Open-CV open source framework.
Coordination infrastructure in collaborative systems (1996)

Research into collaborative software systems has recognized the importance of coordination in promoting effective interactions among collaborators. Coordination is the process of bringing groups of users together into a common action. More specifically, in the computer-supported cooperative work realm, coordination refers to the real world issues of collaborator location, awareness, rendezvous, and policy that must be addressed if collaborative software is to approach the fluidity of physical human interactions.
My research has focused on the development of software infrastructure to support the coordination needs of collaborative applications. In essence, my research examines how to bring contextual information about users and their activities into the mediated computer world, and the implications of having such information available to applications and other users.
Three specific areas of concern are user awareness, session management, and policy control. These areas are interrelated and share a commonality of implementation. This dissertation presents a taxonomy of information sharing in collaborative applications, and examines the three specific topics in detail. I also present an underlying model that can be used to implement the coordination goals provided by my infrastructure.
Colorectal carcinoma: detection with indium-111 anticarcinoembryonic-antigen monoclonal antibody ZCE-025. (1987)

A phase I and II clinical trial with indium-111-labeled anticarcinoembryonic-antigen monoclonal antibody ZCE-025 (In-111 ZCE-025) was initiated. Fifteen patients with colorectal tumors underwent external scintigraphy following the administration of 5.5 mCi (203.5 MBq) In-111 ZCE-025 at doses of 2.5-80.0 mg. Eighteen of 20 documented tumor sites, excluding those in the liver, were detected with In-111 ZCE-025. Lesions less than 1.5 cm could not be detected. Twenty-five percent of liver metastases exhibited positive accumulation of In-111 ZCE-025 at doses of 40-80 mg. No side effects were encountered. Because of the high detection rate of lymph node metastases from colorectal carcinoma with In-111 ZCE-025, this technique may be helpful in preoperative staging of patients with colorectal tumors, as well as in distinguishing recurrent tumors from postoperative or postradiation changes seen on computed tomography scans or other radiologic images.
Streptococcus phocae sp. nov., a New Species Isolated from Clinical Specimens from Seals (1994)

A new beta-hemolytic streptococcal species, Streptococcus phocae, was isolated from organ specimens obtained from seals. This taxon is described on the basis of the results of a study of 22 strains. S. phocae was serologically somewhat heterogeneous (group antigen -/F/C). Strains belonging to this species exhibited high levels of DNA-DNA homology to each other, as determined by DNA-DNA hybridization, but low levels of DNA-DNA homology to the type strains of other streptococcal species. A simple scheme for the differentiation of S. phocae from other beta-hemolytic streptococci is presented. Strain 8399 H1 (= NCTC 12719) is the type strain of S. phocae.
Intracellular pH homeostasis in the filamentous fungus <i>Aspergillus niger</i> (2002)

Intracellular pH homeostasis in the filamentous fungus Aspergillus niger was measured in real time by 31P NMR during perfusion in the NMR tube of fungal biomass immobilized in Ca2+-alginate beads. The fungus maintained constant cytoplasmic pH (pH(cyt)) and vacuolar pH (pH(vac)) values of 7.6 and 6.2, respectively, when the extracellular pH (pH(ex)) was varied between 1.5 and 7.0 in the presence of citrate. Intracellular metabolism did not collapse until a Delta pH over the cytoplasmic membrane of 6.6-6.7 was reached (pH(ex) 0.7-0.8). Maintenance of these large pH differences was possible without increased respiration compared to pH(ex) 5.8. Perfusion in the presence of various hexoses and pentoses (pH(ex) 5.8) revealed that the magnitude of Delta pH values over the cytoplasmic and vacuolar membrane could be linked to the carbon catabolite repressing properties of the carbon source. Also, larger Delta pH values coincided with a higher degree of respiration and increased accumulation of polyphosphate. Addition of protonophore (carbonyl cyanide m-chlorophenylhydrazone, CCCP) to the perfusion buffer led to decreased ATP levels, increased respiration and a partial (1 microm CCCP), transient (2 microm CCCP) or permanent (10 microm CCCP) collapse of the vacuolar membrane Delta pH. Nonlethal levels of the metabolic inhibitor azide (N3-, 0.1 mm) caused a transient decrease in pH(cyt) that was closely paralleled by a transient vacuolar acidification. Vacuolar H+ influx in response to cytoplasmic acidification, also observed during extreme medium acidification, indicates a role in pH homeostasis for this organelle. Finally, 31P NMR spectra of citric acid producing A. niger mycelium showed that despite a combination of low pH(ex) (1.8) and a high acid-secreting capacity, pH(cyt) and pH(vac) values were still well maintained (pH 7.5 and 6.4, respectively).
Capacitor motors with windings not in quadrature (1935)

Quite often the design of a split phase induction motor is such that the so-called quadrature winding is displaced at some angle other than 90 degrees from the main winding, in which event the motor behaves differently when run in opposite directions. It is the purpose of this paper to indicate a method by which the designer can predict the performance of such a motor. While the emphasis is placed upon the capacitor motor, the treatment is applicable also to motors of other types.
How to simplify the structure of administrative procedures to make them easier to write, review, produce, and use (2002)

A simplified structure for administrative procedures is described that makes them easier to write, review, and use. The simplified structure maintains a balance among the fundamental human factors considerations of sound procedures: presenting actions, conditions, and explanations concisely: maintaining consistency of information and format; and ensuring completeness and accuracy of the procedure. With these objectives met, the simplified structure permits procedures that are more clearly defined, more easily automated and more reliable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Bisector Effect on the Twisted-Nematic Cells (1998)

Bisector effects of the twisted-nematic cells are analyzed using Jones matrix method. When the incident polarization angle is at the bisector of the twist angle, the dark state voltage in the crossed-polarizer configuration is greatly reduced. The 90° and 60° twisted cells are used as examples for demonstrating the bisector effect of the transmissive and reflective displays, respectively. Owing to the increased color dispersion, this bisector effect is more suitable for projection systems than for direct-view displays.
Safety and Efficacy of Meloxicam in the Treatment of Osteoarthritis (2000)

Meloxicam is a safe and effective medication for the symptomatic treatment of OA. The data support consideration of 7.5 to 15 mg of meloxicam once daily to treat the pain and stiffness of OA, with gastrointestinal tolerability comparable to that of placebo. Arch Intern Med. 2000;160:2947-2954