gebhart/patrepeval huggingface dataset:
The molecular structure of the complex of Hoechst 33258 and the DNA dodecamer d(CGCGAATTCGCG) (1988)

The crystal structure of the complex between the dodecamer d(CGCGAATTCGCG) and a synthetic dye molecule Hoechst 33258 was solved by X-ray diffraction analysis and refined to an R-factor of 15.7% at 2.25 A resolution. The crescent-shaped Hoechst compound is found to bind to the central four AATT base pairs in the narrow minor groove of the B-DNA double helix. The piperazine ring of the drug has its flat face almost parallel to the aromatic bisbenzimidazole ring and lies sideways in the minor groove. No evidence of disordered structure of the drug is seen in the complex. The binding of Hoechst to DNA is stabilized by a combination of hydrogen bonding, van der Waals interaction and electrostatic interactions. The binding preference for AT base pairs by the drug is the result of the close contact between the Hoechst molecule and the C2 hydrogen atoms of adenine. The nature of these contacts precludes the binding of the drug to G-C base pairs due to the presence of N2 amino groups of guanines. The present crystal structural information agrees well with the data obtained from chemical footprinting experiments.
Influences of laser source on phase-sensitivity optical time-domain reflectometer-based distributed intrusion sensor (2014)

This paper investigates the influences of laser source on distributed intrusion sensor based on a phase-sensitivity optical time-domain reflectometer (φ-OTDR). A numerical simulation is performed to illustrate the relationships between trace-to-trace fluctuations and frequency drift rate as well as pulse width, and fluctuations ratio coefficient (FRC) is proposed to evaluate the level of trace-to-trace fluctuations. The simulation results show that the FRC grows with increasing frequency drift rate and pulse width, reaches, and maintains the peak value when the frequency drift rate and/or the pulse width are high enough. Furthermore, experiments are implemented using a φ-OTDR prototype with a low frequency drift laser (<5 MHz/min), of which the high frequency drift rate is simulated by frequency sweeping. The good agreement of experimental with simulated results in the region of high frequency drift rate validates the theoretical analysis, and the huge differences between them in the region of low frequency drift rate indicate the place of laser frequency drift among system noises. The conclusion is useful for choosing laser sources and improving the performance of φ-OTDR.
Safety and Immunogenicity of UBI HIV-1 <sub>MN</sub> Octameric V3 Peptide Vaccine Administered by Subcutaneous Injection (1997)

Twenty-four HIV-seronegative men, at high risk of HIV infection, were recruited into a phase I/II safety and immunogenicity trial of a prototype HIV vaccine. The immunogen was a synthetic, monovalent, octameric HIV-1MN V3 peptide in an aluminum hydroxide (alum) adjuvant. The vaccine had been evaluated previously using a standard 0-, 1-, 6-month intramuscular schedule and was found to stimulate neutralizing antibody in 60-90% of volunteers. Participants were randomized to receive either 500 micrograms (n = 10; high dose) or 100 micrograms (n = 10; low dose) of immunogen or placebo (alum alone; n = 4) at 0, 1, and 6 months by subcutaneous injection. Responses to the immunogen were evaluated by enzyme-linked immunosorbent assay (ELISA)-detectable antibody and by proliferative responses. Safety was monitored by both clinical assessment and regular review with a clinical psychologist. No serious adverse experiences were observed following administration of the assigned medication. One individual (placebo) seroconverted while on study, following exposure to HIV. After the vaccination course only four individuals (three high dose and one low dose) had ELISA-detectable antibody against the immunogen. In the evaluable samples, from 19 volunteers, only 7 vaccine recipients (3 high dose and 4 low dose) had demonstrable lymphoproliferative responses to preparations of the immunogen. Subcutaneous administration of its candidate vaccine was safe but did not result in uniform or robust immunological responses.
Free and smooth boundaries in 2-D finite-difference schemes for transient elastic waves (2007)

A method is proposed for accurately describing arbitrary-shaped free boundaries in finite-difference schemes for elastodynamics, in a time-domain velocity–stress framework. The basic idea is as follows: fictitious values of the solution are built in vacuum, and injected into the numerical integration scheme near boundaries. The most original feature of this method is the way in which these fictitious values are calculated. They are based on boundary conditions and compatibility conditions satisfied by the successive spatial derivatives of the solution, up to a given order that depends on the spatial accuracy of the integration scheme adopted. Since the work is mostly done during the pre-processing step, the extra computational cost is negligible. Stress-free conditions can be designed at any arbitrary order without any numerical instability, as numerically checked. Using 10 grid nodes per minimal S-wavelength with a propagation distance of 50 wavelengths yields highly accurate results. With 5 grid nodes per minimal S-wavelength, the solution is less accurate but still acceptable. A subcell resolution of the boundary inside the Cartesian meshing is obtained, and the spurious diffractions induced by staircase descriptions of boundaries are avoided. Contrary to what occurs with the vacuum method, the quality of the numerical solution obtained with this method is almost independent of the angle between the free boundary and the Cartesian meshing.
Picosecond time-resolved circular dichroism spectroscopy: experimental details and applications (1989)

An experimental apparatus for measuring time-resolved circular dichroism (CD) with picosecond resolution is described. The time resolution of the device is determined by the laser pulse width, not the modulation frequency of an electro-optic or piezo-optic crystal as is the case for commercial CD spectrometers. The time-dependent CD signal can be monitored over the wavelength range from 280 to 850 nm. The data from single wavelength studies can be pieced together to generate time dependent spectra. The experimental approach is compared to previous time-resolved CD techniques which, for technical reasons, have been limited to, at most, nanosecond resolution. The picosecond apparatus is shown to be free of many of the polarization artifacts present in these previous devices. The utility of this technique is demonstrated by examining result on the time dependent near-UV CD of myoglobin following the photoelimination of coordinated CO from carbonmonoxymyoglobin.
Goldmann Applanation Tonometry without Fluorescein (1981)

Recently, there have been several suggestions that Goldmann applanation tonometry can be performed without fluorescein. In order to determine the clinical efficacy of performing Goldmann applanation tonometry without fluorescein, 100 consecutive patients had applanation tonometry performed without fluorescein (Ophthetic only) and with fluorescein (Fluress), according to a predetermined randomization schedule. It was found that the average difference between readings with fluorescein and without fluorescein was 7.01 mm Hg. Tonometry readings without fluorescein were lower than readings with fluorescein. In addition, regression analysis indicated that the differences between the readings with and without fluorescein increased as intraocular pressure increased. By not utilizing fluorescein in Goldmann applanation tonometry, the clinician will record lower readings. In addition, greater errors in measurement occur with increasing intraocular pressures. Because eyes with higher intraocular pressures are at a greater risk to develop glaucomatous optic atrophy and loss of visual field, the merits of Goldmann applanation tonometry without fluorescein are speculative.
Rational Design to Block Amino Acid Editing of a tRNA Synthetase [<i>J. Am. Chem. Soc.</i> <b>2002</b>, <i>124</i>, 7286−7287]. (2003)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionRational Design to Block Amino Acid Editing of a tRNA Synthetase [J. Am. Chem. Soc.2002, 124, 7286−7287].Richard S. Mursinna and Susan A. MartinisCite this: J. Am. Chem. Soc. 2003, 125, 38, 11773Publication Date (Web):August 29, 2003Publication History Published online29 August 2003Published inissue 1 September 2003https://pubs.acs.org/doi/10.1021/ja033453nhttps://doi.org/10.1021/ja033453ncorrectionACS PublicationsCopyright © 2003 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views289Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (13 KB) Get e-Alertsclose Get e-Alerts
Metalation reactions. III. Metalation of octadecynols and octadecynyl methyl ethers (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetalation reactions. III. Metalation of octadecynols and octadecynyl methyl ethersJoseph Klein and E. GurfinkelCite this: J. Org. Chem. 1969, 34, 12, 3952–3958Publication Date (Print):December 1, 1969Publication History Published online1 May 2002Published inissue 1 December 1969https://pubs.acs.org/doi/10.1021/jo01264a044https://doi.org/10.1021/jo01264a044research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Theoretische Grundlagen (1988)

Der Zustand eines festen Körpers wird durch die Angabe der sechs Spannungs- und der drei Verschiebungskomponenten für jeden Punkt seines Volumens beschrieben. Die Belastung des Körpers wird durch eine in Funktion des Ortes variable Volumenkraft und vorgeschriebene Randspannungen, die statischen Randbedingungen, berücksichtigt. Seine Lagerung wird durch vorgegebene Randverschiebungen, die kinematischen Randbedingungen, ausgedrückt.
The Role of Electrolyte Upon the SEI Formation Characteristics and Low Temperature Performance of Lithium-Ion Cells With Graphite Anodes (1998)

Quarternary lithium-ion battery electrolyte solutions containing ester co-solvents in mixtures of carbonates have been demonstrated to have high conductivity at low temperatures (< -20C). However, in some cases the presence of such co-solvents does not directly translate into improved low temperature cell performance, presumably due to the formation of ionically resistive surface films on carbonaceous anodes. In order to understand this behavior, a number of lithium-graphite cells have been studied containing electrolytes with various ester co-solvents, including methyl acetate (MA), ethyl acetate (EA), ethyl propionate (EP), and ethyl butyrate (EB). The charge/discharge characterization of these cells indicates that the higher molecular weight esters result in electrolytes which possess superior low temperature performance in contrast to the lower molecular weight ester-containing solutions, even though these solutions display lower conductivity values.
Effect of substitutional doping on the Néel temperature of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mi mathvariant="bold">Cr</mml:mi><mml:mn mathvariant="bold">2</mml:mn></mml:msub><mml:msub><mml:mi mathvariant="bold">O</mml:mi><mml:mn mathvariant="bold">3</mml:mn></mml:msub></mml:mrow></mml:math> (2013)

First-principles calculations are used to explore the possibility of enhancing the N\'eel temperature ${T}_{N}$ of the magnetoelectric antiferromagnet Cr${}_{2}$O${}_{3}$ by substitutional doping. We describe the electronic structure of transition metal (V, Ti, Mn, Fe, Co, and Ni) and anion (N and B) impurities and evaluate their effect on the exchange interaction. We find that, although transition-metal impurities and N are likely to reduce ${T}_{N}$, substitution of O by B is likely to increase it. Both N and B impurities introduce impurity states mediating strong hybridization and magnetic interaction between the neighboring Cr ions. For N impurities, this leads to magnetic frustration, but in the case of B substitution, the stability of the ground antiferromagnetic state is enhanced.
Applications of DNA Flow Cytometry and Fluorescence <i>In situ</i> Hybridization Using a Chromosome‐specific DNA Probe on Paraffin‐embedded Tissue Sections of Primary Malignant Melanomas (1994)

We have applied DNA flow cytometric analysis to paraffin-embedded tissue sections of primary malignant melanomas. Conventionally, flow cytometric analysis of paraffin-embedded tissue sections has been done by the method of Hedley et al. We added ultrasound treatment to the method of Hedley et al. and a lower value of coefficient of variation was shown. Furthermore, a new technique, fluorescence in situ hybridization with a chromosome-specific repetitive DNA probe, was used for the analysis of chromosomal numerical aberrations in the same paraffin-embedded tissue sections. The DNA flow cytometric analysis showed that in 8 cases six primary malignant melanomas were of the aneuploid pattern and two cases of lentigo maligna (melanoma in situ) were of the diploid pattern. By fluorescence in situ hybridization, the two cases with the diploid pattern had spots/nucleus of 1.28 and 1.12, and those with the aneuploid pattern had spots/nucleus from 2.01 to 2.27. Only one nodular melanoma in an aneuploid case showed spots/nucleus of 1.71. These data indicate that fluorescence in situ hybridization with chromosome-specific repetitive DNA probes can serve as a cytogenetic tool for the analysis of interphase nuclei of solid human tumors and may be useful for the study of tumor cell heterogeneity.
Increased Body Iron Stores Are Associated With Poor Outcome After Thrombolytic Treatment in Acute Stroke (2006)

Increased body iron stores are associated with poor outcome, symptomatic hemorrhagic transformation, and severe edema in patients treated with tissue plasminogen activator after ischemic stroke. These findings suggest that iron overload may offset the beneficial effect of thrombolytic therapies.
Excel® VBA Programming For Dummies® (2010)

Take control of your spreadsheets and use VBA to create your own custom Excel applicationsAuthor and Excel guru John Walkenbach, known to his devoted fans as Mr. Spreadsheet, guides you through taking your Excel skills to the next level by creating your own customized spreadsheet solutions using Visual Basic for Applications (VBA). This updated edition of this bestselling book shows you how to use VBA, write macros, customize your Excel apps to look and work the way you want, avoid errors, and more.Introduces you to a wide array of new Excel 2013 options, beginning with the most important tools and operations for the Visual Basic EditorProvides an overview of the essential elements and concepts for programming with Excel, including using VBA to customize your applications and automate functionsShares techniques for handling errors, debugging, working with range objects, controlling flow, and much moreZeroes in on creating custom dialog boxes, toolbars, and menusAdd a personal touch to your spreadsheets and present your data the way you want with Excel VBA Programming For Dummies, 3rd Edition.
Songs of War: Anglo-Canadian Popular Songs on the Home Front, 1914-1918 (2019)

This article explores the production, content, and reception of Anglo-Canadian popular songs composed during the First World War. It argues that popular songs reflected the changing attitudes of Anglo-Canadians, as composers and publishers created music to fulfill different purposes for those on the home front at various stages of the war. In the beginning, the majority of songs were patriotic marches composed to gather support for Britain and the Empire. As the war continued, there was an increase in the number of patriotic songs that expressed a growing sense of wartime Canadian nationalism to enlist recruits. Throughout the war, music was significant to the First World War experience on Canada’s home front.
Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice (2007)

The serine palmitoyl transferase inhibitor myriocin potently suppresses the development of atherosclerosis in apolipoprotein E (apoE) gene knockout (apoE(-/-)) mice fed a high-fat diet. This is associated with reduced plasma sphingomyelin (SM) and glycosphingolipid levels. Furthermore, oral administration of myriocin decreases plasma cholesterol and triglyceride (TG) levels. Here, we aimed to determine whether myriocin could inhibit the progression (or stimulate the regression) of established atherosclerotic lesions and to examine potential changes in hepatic and plasma lipid concentrations. Adult apoE(-/-) mice were fed a high-fat diet for 30 days, and lesion formation was histologically confirmed. Replicate groups of mice were then transferred to either regular chow or chow containing myriocin (0.3 mg/kg/day) and maintained for a further 60 days. Myriocin significantly inhibited the progression of established atherosclerosis when combined lesion areas (aortic sinus, arch, and celiac branch point) were measured. Although the inhibition of lesion progression was observed mainly in the distal regions of the aorta, regression of lesion size was not detected. The inhibition of lesion progression was associated with reductions in hepatic and plasma SM, cholesterol, and TG levels and increased hepatic and plasma apoA-I levels, indicating that the modulation of pathways associated with several classes of atherogenic lipids may be involved.
On the Edge of Autoimmunity (2005)

Targeting of antigens to immature dendritic cells has been shown to result in antigen-specific T-cell tolerance in vivo. In the INS-HA/TCR-HA transgenic mouse model for type 1 diabetes, we tested the potential of the dendritic cell-specific monoclonal antibody DEC-205 conjugated to the hemagglutinin (HA) antigen (DEC-HA) to prevent disease onset. Whereas untreated INS-HA/TCR-HA mice all develop insulitis, and approximately 40% of these mice become diabetic, repeated injection of newborn mice with DEC-HA protected almost all mice from disease development. Histological examination of the pancreata revealed significant reduction of peri-islet infiltrations in DEC-HA-treated mice, and the islet structure remained intact. Moreover, HA-specific CD4+ T-cells from anti-DEC-HA-treated INS-HA/TCR-HA mice exhibited increased expression of Foxp3, cytotoxic T-lymphocyte-associated antigen-4, and the immunosuppressive cytokines interleukin-10 and transforming growth factor-beta. The findings indicate that targeting of the HA antigen to immature dendritic cells in vivo leads to a relative increase of antigen-specific Foxp3+ regulatory T-cells that suppress the development of type 1 diabetes. Our results provide a basis for the development of novel strategies focusing on prevention rather than treatment of autoimmune diseases.
On the Mode-Matched Control of MEMS Vibratory Gyroscope via Phase-Domain Analysis and Design (2009)

This paper investigates a novel method for the mode-matched control of a microelectromechanical systems (MEMS) vibratory gyroscope through a phase-domain analysis. Compared with the previous works, the proposed method presents a simple and robust automatic mode tuning scheme for sensitivity enhancement. In designing the mode-matched control loop, the resonant characteristics of the driving axis are used as the reference mode. Then, the phase difference between sense and drive modes at the resonant frequency of drive mode is used to generate a control signal for phase error regulation. For the control loop design, a linear phase-locked loop is adapted. Through the simulation using practical MEMS gyroscope parameters, the mode-matching performance and robustness of the designed control loop is demonstrated. It is also shown that coupling effect yields no degradation of output sensitivity. Finally, the experimental results obtained by implementing the electronics of mode-matched control verify the feasibility of the proposed method.
Influence of the Choice of Indium Precursor and Ligand on the Synthesis of InP Nanocrystals (2007)

Well-crystallized InP nanocrystals with particle diameters ranging from 2 to 5.5nm were prepared via the reaction between tris(trimethylsilyl)phosphine and different indium precursors. The classic TOP/TOPO reaction medium was replaced by the weakly coordinating solvent diphenylether, which contained a strongly coordinating ligand at low concentrations. Different phosphine oxides, phosphines, phosphates, phosphites and phosphonates were used as ligands and their influence on the growth of InP nanocrystals was studied. The synthesis procedure allows to prepare crystalline InP quantum dots (QDs) at temperatures as low as 150°C and within short reaction times. The final size of the InP QDs is remarkably independent of the choice of ligand and indium precursor.