gebhart/patrepeval huggingface dataset:
Learning Subjective Adjectives from Corpora (2000)

Subjectivity tagging is distinguishing sentences used to present opinions and evaluations from sentences used to objectively present factual information. There are numerous applications for which subjectivity tagging is relevant, including information extraction and information retrieval. This paper identifies strong clues of subjectivity using the results of a method for clustering words according to distributional similarity (Lin 1998), seeded by a small amount of detailed manual annotation. These features are then further refined with the addition of lexical semantic features of adjectives, specifically polarity and gradability (Hatzivassiloglou &amp; McKeown 1997), which can be automatically learned from corpora. In 10-fold cross validation experiments, features based on both similarity clusters and the lexical semantic features are shown to have higher precision than features based on each alone.
Fast atom bombardment mass spectrometry of cobalamines (1981)

Fast atom bombardment, a new method of ionizing molecules for mass spectrometry, has been found to be particularly applicable to molecules of an involatile nature. The mass spectra of vitamin B12 and related cobalamines are reported together with the mass spectrum of the coenzyme of vitamin B12. Fully resolved spectra, containing both molecular species and structurally significant fragmentation are reported for the first time.
Bishexa-<i>p</i><i>eri</i>-hexabenzocoronenyl:  A “Superbiphenyl” (2000)

The alkyl-substituted bishexa-peri-hexabenzocoronenyls 3a and 3b as well as the related alkyl-substituted dihexa-peri-hexabenzocoronenyldodecane 4 were synthesized. The good solubility of these compounds allowed a comprehensive spectroscopic characterization in solution. Both 3a and 4 form liquid crystalline phases, while only in the case of 4 could a highly ordered columnar structure with a hexagonal superstructure be observed. Photophysical studies in solution revealed a strong intramolecular interaction of the aromatic cores of 3a, in contrast to 4, where only weak intramolecular interactions could be observed. Compound 3a forms monomolecular adsorbate layers on graphite which were characterized by scanning tunneling microscopy.
Exploring Layer Trajectory LSTM with Depth Processing Units and Attention (2018)

Traditional LSTM model and its variants normally work in a frame-by-frame and layer-by-layer fashion, which deals with the temporal modeling and target classification problems at the same time. In this paper, we extend our recently proposed layer trajectory LSTM (ltLSTM) and present a generalized framework, which is equipped with a depth processing block that scans the hidden states of each time-LSTM layer, and uses the summarized layer trajectory information for final senone classification. We explore different modeling units used in the depth processing block to have a good tradeoff between accuracy and runtime cost. Furthermore, we integrate an attention module into this framework to explore wide context information, which is especially beneficial for uni-directional LSTMs. Trained with 30 thousand hours of EN-US Microsoft internal data and cross entropy criterion, the proposed generalized ltLSTM performed significantly better than the standard multi-layer time-LSTM, with up to 12.8% relative word error rate (WER) reduction across different tasks. With attention modeling, the relative WER reduction can be up to 17.9%. We observed similar gain when the models were trained with sequence discriminative training criterion.
The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAP<sub>c</sub> largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1 (1998)

The RNA polymerases II and III snRNA gene promoters contain an octamer sequence as part of the enhancer and a proximal sequence element (PSE) as part of the core promoter. The octamer and the PSE bind the POU domain activator Oct-1 and the basal transcription factor SNAPc, respectively. Oct-1, but not Oct-1 with a single E7R mutation within the POU domain, binds cooperatively with SNAPc and, in effect, recruits SNAPc to the PSE. Here, we show that SNAPc recruitment is mediated by an interaction between the Oct-1 POU domain and a small region of the largest subunit of SNAPc, SNAP190. This SNAP190 region is strikingly similar to a region in the B-cell-specific Oct-1 coactivator, OBF-1, that is required for interaction with octamer-bound Oct-1 POU domain. The Oct-1 POU domain-SNAP190 interaction is a direct protein-protein contact as determined by the isolation of a switched specificity SNAP190 mutant that interacts with Oct-1 POU E7R but not with wild-type Oct-1 POU. We also show that this direct protein-protein contact results in activation of transcription. Thus, we have identified an activation target of a human activator, Oct-1, within its cognate basal transcription complex.
A type 5 acid phosphatase gene from Arabidopsis thaliana is induced by phosphate starvation and by some other types of phosphate mobilising/oxidative stress conditions (1999)

Low phosphorous availability, a common condition of many soils, is known to stimulate phosphatase activity in plants; however, the molecular details of this response remain mostly unknown. We purified and sequenced the N-terminal region of a phosphate starvation induced acid phosphatase (AtACP5) from Arabidopsis thaliana, and cloned its cDNA and the corresponding genomic DNA. The nucleotide sequence of the cDNA predicted that AtACP5 is synthesised as a 338 amino acid-long precursor with a signal peptide. AtACP5 was found to be related to known purple acid phosphatases, especially to mammal type 5 acid phosphatases. Other similarities with purple acid phosphatases, which contain a dinuclear metal centre, include the conservation of all residues involved in metal ligand binding and resistance to tartrate inhibition. In addition, AtACP5, like other type 5 acid phosphatases, displayed peroxidation activity. Northern hybridisation experiments, as well as in situ glucuronidase (GUS) activity assays on transgenic plants harbouring AtACP5:GUS translational fusions, showed that AtACP5 is not only responsive to phosphate starvation but also to ABA and salt stress. It is also expressed in senescent leaves and during oxidative stress induced by H2O2, but not by paraquat or salicylic acid. Given its bifunctionality, as it displays both phosphatase and peroxidation activity, we propose that AtACP5 could be involved in phosphate mobilisation and in the metabolism of reactive oxygen species in stressed or senescent parts of the plant.
Endoplasmic Reticulum Stress Causes Thyroglobulin Retention in this Organelle and Triggers Activation of Nuclear Factor-κB Via Tumor Necrosis Factor Receptor-Associated Factor 2 (2002)

Perturbing the endoplasmic reticulum homeostasis of thyroid cell lines with thapsigargin, a specific inhibitor of the sarcoendoplasmic reticulum Ca(2+) adenosine triphosphatases, and tunicamycin, an inhibitor of the N-linked glycosylation, blocked Tg in the endoplasmic reticulum. This event was signaled outside the endoplasmic reticulum and resulted in activation of the c-Jun N-terminal kinase (JNK)/stress-activated protein kinase and nuclear factor-kappa B (NF-kappa B) stress response pathways. Activation of the JNK/stress-activated protein kinase signaling pathway was assessed by measuring the amount of phospho-JNK and the activity of JNK by kinase assays. Activation of the NF-kappa B signaling pathway was assessed by measuring the level of inhibitory subunit I kappa B alpha, DNA binding, and transcriptional activity of NF-kappa B. Cycloheximide treatment, at a dose able to profoundly inhibit protein synthesis in FRTL-5 cells, obliterated the decrease in the level of the inhibitory subunit I kappa B alpha produced by thapsigargin and tunicamycin. Therefore, protein synthesis was required to generate a signal from stressed endoplasmic reticulum. This substantiates the hypothesis that endoplasmic reticulum retention of newly synthesized Tg and other cargo (secretory and membrane) proteins functions upstream of signal activation. Dominant negative TNF receptor-associated factor 2 (TRAF2) inhibited activation of NF-kappa B, which was also inhibited in embryonic fibroblasts derived from TRAF2(-/-) mice, respect to their normal counterpart. These data extend the recent demonstration that TRAF2 mediated JNK activation in response to endoplasmic reticulum stress and strongly strengthened the idea that endogenous stress signals initiated in the endoplasmic reticulum proceed by a pathway similar to that initiated by plasma membrane receptors in response to extracellular signals.
Cloning and characterization of Rrp1, the gene encoding<i>Drosophila</i>strand transferase: carboxy-terminal homology to DNA repair endo/exonucleases (1991)

We previously reported the purification of a protein from Drosophila embryo extracts that carries out the strand transfer step in homologous recombination (Lowenhaupt, K., Sander, M., Hauser, C. and A. Rich, 1989, J. Biol. Chem. 264, 20568). We report here the isolation of the gene encoding this protein. Partial amino acid sequence from a tryptic digest of gel purified strand transfer protein was used to design a pair of degenerate oligonucleotide primers which amplified a 635 bp region of Drosophila genomic DNA. Recombinant bacteriophage were isolated from genomic and embryo cDNA libraries by screening with the amplified DNA fragment. These bacteriophage clones identify a single copy gene that expresses a single mRNA transcript in early embryos and in embryo-derived tissue culture cells. The cDNA nucleotide sequence contains an open reading frame of 679 amino acids within which are found 5 tryptic peptides from the strand transfer protein. Expression of this cDNA in E. coli produces a polypeptide with the same electrophoretic mobility as the purified protein. The deduced protein sequence has two distinct regions. The first 427 residues are basic, rich in glutamic acid and lysine residues and unrelated to known proteins. The carboxy-terminal 252 residues are average in amino acid composition and are homologous to the DNA repair proteins, Escherichia coli exonuclease III and Streptococcus pneumoniae exonuclease A. This protein, which we name Rrp1 (Recombination Repair Protein 1), may facilitate recombinational repair of DNA damage.
Efficient History Matching of Thermally Induced Fractures Using Coupled Geomechanics and Reservoir Simulation (2020)

Waterflooding is a common recovery method used to maintain reservoir pressure and improve reservoir oil sweep efficiency. However, injecting cold water into a reservoir alters the state of in-situ formation stress and can result in the formation fracturing. In other words, it can cause the initiation and growth of thermally induced fractures (TIFs), even when the original fracture propagation pressure is not exceeded. TIFs can cause non-uniform distribution of the fluid flow in wellbores, a reduction in sweep efficiency, and early water breakthrough in nearby production wells. Modelling and history matching workflows that consider the dynamic nature of the TIF problem are critical. These workflows improve and validate reservoir and geomechanical models, identify and confirm observed TIF onset and propagation periods, and provide a history-matched sector model with the rock mechanical and thermal properties and stress gradients that can be used with confidence for subsequent studies. Modelling and the underlining assumptions of fluid flow in the TIF and reservoir matrix, as well as geomechanical changes due to cooling of the reservoir during injection, are detailed below. A 3D reservoir simulator coupled with 2D finite element TIF and geomechanical models were used to manually history match an injector (NI6) in the N Field sector reservoir model in which a TIF was observed. In this study, history matching workflows were developed to consider the dynamic nature of TIF development during waterflooding. The reservoir and geomechanical models were improved and validated via the observed TIF onset and propagation periods. The history-matched models produced can be used with confidence in subsequent studies. The practical workflows and guidelines developed here can be used in waterflooding operations during the modelling, design, and planning stages. The novelty of this study is the coupling approach of different complex processes done in order to capture dynamic changes during waterflooding operations. A similar history matching study could not be found in the literature.
The Cytoplasmic Domain of Igα Is Necessary and Sufficient to Support Efficient Early B Cell Development (2004)

The B cell receptor complex (BcR) is essential for normal B lymphocyte function, and surface BcR expression is a crucial checkpoint in B cell development. However, functional requirements for chains of the BcR during development remain controversial. We have used retroviral gene transfer to introduce components of the BcR into chicken B cell precursors during embryonic development. A chimeric heterodimer, in which the cytoplasmic domains of chicken Igalpha and Igbeta are expressed by fusion with the extracellular and transmembrane domains of murine CD8alpha and CD8beta, respectively, targeted the cytoplasmic domains of the BcR to the cell surface in the absence of extracellular BcR domains. Expression of this chimeric heterodimer supported all early stages of embryo B cell development: bursal colonization, clonal expansion, and induction of repertoire diversification by gene conversion. Expression of the cytoplasmic domain of Igalpha, in the absence of the cytoplasmic domain of Igbeta, was not only necessary, but sufficient to support B cell development as efficiently as the endogenous BcR. In contrast, expression of the cytoplasmic domain of Igbeta in the absence of the cytoplasmic domain of Igalpha failed to support B cell development. The ability of the cytoplasmic domain of Igalpha to support early B cell development required a functional Igalpha immunoreceptor tyrosine-based activation motif. These results support a model in which expression of surface IgM following productive V(D)J recombination in developing B cell precursors serves to chaperone the cytoplasmic domain of Igalpha to the B cell surface, thereby initiating subsequent stages of development.
Timing phase estimator overcoming Rayleigh fading for OFDM systems (2001)

A timing offset estimator robust to a Rayleigh fading channel and a fast Fourier transform (FFT) window selection algorithm that can remove inter symbol interference (ISI) are proposed for an orthogonal frequency division multiplexing (OFDM) system. Conventional algorithms using the scattered pilots for timing offset estimation only use phase information, whereas the proposed algorithm utilizes both phase and amplitude information. The use of amplitude information in the proposed algorithm means that the influence of distorted pilots due to fading becomes insignificant when estimating a timing offset. As a result, the proposed algorithm is robust to multipath fading channels and produces a superior performance with less computational complexity compared to conventional algorithms. The proposed FFT window selection algorithm based on the cyclic extension property of the OFDM structure can remove the ISI problems caused by multipath fading channels, thereby significantly improving the receiver performance without any additional computational requirements. The paper uses the DVB-T standard to evaluate the algorithms.
ChemInform Abstract: Preparation of Dialkyl Disulfides via Reduction of Alkylthiocyanates with TiCl4/Sm System. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fast, Acid-Free, and Selective Lactamization of Lactones in Ionic Liquids (2008)

A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both gamma-lactams and delta-lactams were, despite the complete absence of a Brønsted acid, obtained in useful to excellent yields after only 35 min of microwave processing.
Power Interval Communication Technology Over Turn Circuit (1997)

<div class="htmlview paragraph">Presented in this paper is a new multiplex communications technology that economically permits a two-way transfer of information (data) between a tractor and trailer(s) through the standard SAE J560 connector. Power Interval Communications Technology (PICT) is a single wire, serial communication system that is transmitted over the existing turn signal circuit.</div> <div class="htmlview paragraph">This paper will show the basic approach of the PICT system and the major advantages it offers. PICT allows the use of the current SAE J560 connector to provide an in-cab trailer ABS fault indication. PICT, transmitted over the turn circuit, is compatible with all tractor and trailers, old and new, because this circuit is common to all vehicles. PICT is a very economical solution because no twisted pair communications wiring is required, no in-line switched communications techniques are required, no sophisticated interface circuitry is required, and no additional connections are required between the tractor and trailer. The PICT system utilizes the standard SAE J560 connector, existing tractor and trailer wiring, and electronic modules that communicate with one another via the turn signal circuit.</div> <div class="htmlview paragraph">The PICT communication system also has the capability of achieving productivity and safety increases for tractor/trailer owners. PICT's 2-way communication allows additional features in the trailer such as door ajar. tire pressure, brake pressure. reefer temperature, dome lamp control and another power switching function, plus a number of other functions that can be controlled and monitored in the cab.</div>
Trickle‐bed reactors: A review (1983)

Abstract Fixed‐bed, catalytic reactors in which gas and liquid phases flow concurrently downward, termed trickle beds, are becoming more widely used in chemical processing, particularly in the petrochemical industry. Shah (1979) has summarized the advantages of trickle‐bed reactors and mentioned some of the processes in which the reactors are used. Shah's monograph and earlier reviews (Satterfield, 1975; Goto et al., 1977; Hofmann, 1978; Gianetto et al., 1978) have discussed factors affecting reactor performance. In the last few years additional experimental and theoretical studies that contribute to improved design and scaleup of trickle‐bed reactors have been published. The scope of this paper is to review critically these improvements. Progress in understanding local rates of reaction is considered first. Then recent developments in reactor design are analyzed.
Multidimensional scaling (2012)

The concept of similarity, or a sense of 'sameness' among things, is pivotal to theories in the cognitive sciences and beyond. Similarity, however, is a difficult thing to measure. Multidimensional scaling (MDS) is a tool by which researchers can obtain quantitative estimates of similarity among groups of items. More formally, MDS refers to a set of statistical techniques that are used to reduce the complexity of a data set, permitting visual appreciation of the underlying relational structures contained therein. The current paper provides an overview of MDS. We discuss key aspects of performing this technique, such as methods that can be used to collect similarity estimates, analytic techniques for treating proximity data, and various concerns regarding interpretation of the MDS output. MDS analyses of two novel data sets are also included, highlighting in step-by-step fashion how MDS is performed, and key issues that may arise during analysis. WIREs Cogn Sci 2013, 4:93-103. doi: 10.1002/wcs.1203 This article is categorized under: Psychology > Perception and Psychophysics.
Is software quality visible in the code (1998)

Finding and fixing software code defects is crucial to product quality. It also, however, often proves difficult and time-consuming, especially late in the development cycle. While some believe that code analysis provides a simple way to detect quality defects, the authors argue otherwise. To prove their point, they analyzed data from error reports, and their results show that code analysis detects only a small percentage of meaningful defects.
Distal radius fracture and the distal radioulnar joint--anatomical considerations. (1994)

The ulna represents the non-rotating, stable and weightbearing part of the forearm around which the radius rotates in pronation and supination. The distal radioulnar joint is the distal half of an articulation, the proximal half of which is the proximal radioulnar joint. In spite of the distance between the two, the distal and proximal radioulnar joints together form a bi-condylar joint, the "forearm joint", with the axis of rotation running from the centre of the radial head out distally into the interosseous space towards the centre of the ulnar head. The end of the radius together with the hand and what is held in the hand will rest against the stable, immobile ulnar head, which acts as the keystone of the wrist. Mobility and stability of the distal radioulnar joint is accomplished by the combined action between fully congruent articulating surfaces and intact radioulnar ligaments. Following a distal radius fracture, the semilunar notch of the radius will no longer be congruent to the ulnar head due to the displacement of the distal fracture fragment of the radius into either dorsal angulation, radial angulation, or both. The stabilizing ligaments will tear. Any posttraumatic disabling dysfunction of the distal radioulnar joint should accordingly be treated by a corrective osteotomy of the radius at the fracture site in order to achieve full congruity between the semilunar notch and the ulnar head. Resection of the ulnar head deprives the wrist its keystone and should therefore be avoided.
Therapeutic potential of octyl gallate isolated from fruits of<i>Terminalia bellerica</i>in streptozotocin-induced diabetic rats (2013)

OG might have augmented the secretion of insulin by the modulation of cAMP and intracellular calcium levels in the β cells of the pancreas. Our findings indicate that OG isolated first time from the fruit rind of T. bellerica has potential antidiabetic effect as it augments insulin secretion and normalizes the altered biochemical parameters in experimental diabetic rat models.
Characterization of human tissue carnosinase (1985)

Human tissue carnosinase (EC 3.4.13.3) had optimum activity at pH9.5 and was a cysteine peptidase, being activated by dithiothreitol and inhibited by p-hydroxymercuribenzoate. By optimizing assay conditions, the activity per g of tissue was increased 10-fold compared with values in the literature. The enzyme was present in every human tissue assayed and was entirely different from serum carnosinase. Highly purified tissue carnosinase had a broader specificity than hog kidney carnosinase. Although tissue carnosinase was very strongly inhibited by bestatin, it did not hydrolyse tripeptides, and thus appears to be a dipeptidase rather than an aminopeptidase. It had a relative molecular mass of 90 000, an isoelectric point of 5.6, and a Km value of 10 mM-carnosine. Two forms of kidney and brain carnosinase were separated by high-resolution anion-exchange chromatography, although only one form was detected by various electrophoretic methods. Homocarnosinase and Mn2+-independent carnosinase were not detected in human tissues, although these enzymes are present in rat and hog kidney.