gebhart/patrepeval huggingface dataset:
The design of a high performance information filtering system (1996)

A high performance information filtering system has three main requirements: it must be effective in supplying users with useful information, it must do so in a timely fashion, and it must be able to handle a large throughput of information and a large number of user profiles efficiently. These three requirements pose a difficult problem, and to our knowledge no existing system is capable of meeting all three. In this paper we describe a system which combines a number of techniques from other information retrieval and filtering systems, and is capable of providing high performance on a typical workstation platform. We provide estimates of computing resource usage, and show that our system is also scalable.
Implementation of a systematic distribution transformer load management in Taipower (2009)

The practice of transformer load management (TLM) in Taipower to determine the daily power profile and the peak loading of distribution transformers by integration of customer information systems (CISs) such as, automated mapping/facilities management/geographic information system and load survey system is presented. The load survey study is conducted by selecting 672 customers for installation of digital power meters to measure the customer power consumption within 15 min intervals. The typical load patterns of low-voltage residential, commercial and industrial customer classes are derived by executing statistic analysis of power consumption of test customers. A narrow-band power line carrier-based identifier is developed to identify all of the customers served by each distribution transformer. The hourly power consumption of each customer is determined by allocating the monthly energy consumption according to the typical load pattern of the corresponding customer class. The peak loading of each distribution transformer is then estimated by integrating the power consumption of all customers served. The overloading flags and peak loading levels of all transformers are then displayed on the digital mapping system. The TLM program proposed in this study has effectively assisted Taipower distribution engineers to identify the potentially overloading transformers for load reduction to mitigate the transformer damage during the hot summer season.
Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus (2017)

Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi.
Performance of 200 V CMOS compatible auxiliary cathode lateral insulated gate transistors (2002)

The authors report the performance of various anode-shorted auxiliary cathode lateral insulated gate transistor (ACLIGT) structures fabricated using a 2.5 mu m digital CMOS compatible HVIC process. The reverse breakdown voltage of the ACLIGT is comparable to that of an equivalent anode shorted lateral insulated gate transistor (LIGT). The results indicate that, by placing an auxiliary cathode and an extended p-buried layer of an anode-shorted LIGT, the holes flowing into the p-well can be diverted to overcome the latch-up problems of the LIGT in an ACLIGT. The LIGT shows latch-up at 140 mA, which corresponds to a current density of 340 A/cm/sup 2/ while the ACLIGT structures do not show latch-up. The measured turn-off characteristics of the ACLIGT reveal a turn-off time of less than 250 ns while an equivalent LIGT shows a turn-off time of 350 ns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Thiolated DNA-Based Chemistry and Control in the Structure and Optical Properties of Plasmonic Nanoparticles with Ultrasmall Interior Nanogap (2014)

The design, synthesis and control of plasmonic nanostructures, especially with ultrasmall plasmonically coupled nanogap (∼1 nm or smaller), are of significant interest and importance in chemistry, nanoscience, materials science, optics and nanobiotechnology. Here, we studied and established the thiolated DNA-based synthetic principles and methods in forming and controlling Au core-nanogap-Au shell structures [Au-nanobridged nanogap particles (Au-NNPs)] with various interior nanogap and Au shell structures. We found that differences in the binding affinities and modes among four different bases to Au core, DNA sequence, DNA grafting density and chemical reagents alter Au shell growth mechanism and interior nanogap-forming process on thiolated DNA-modified Au core. Importantly, poly A or poly C sequence creates a wider interior nanogap with a smoother Au shell, while poly T sequence results in a narrower interstitial interior gap with rougher Au shell, and on the basis of the electromagnetic field calculation and experimental results, we unraveled the relationships between the width of the interior plasmonic nanogap, Au shell structure, electromagnetic field and surface-enhanced Raman scattering. These principles and findings shown in this paper offer the fundamental basis for the thiolated DNA-based chemistry in forming and controlling metal nanostructures with ∼1 nm plasmonic gap and insight in the optical properties of the plasmonic NNPs, and these plasmonic nanogap structures are useful as strong and controllable optical signal-generating nanoprobes.
Chapter 11. Synthetic methods (1984)

A. P. Davis, Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 1984, 81, 247 DOI: 10.1039/OC9848100247
Adjusting the frameworks of polymeric silver(i) complexes with 2-aminopyrimidyl ligands by changing the counterions (2006)

The complexes [Ag2(L)2(SO4)]∞, (L = 2-aminopyrimidine) 1, [Ag(L)1.5(ClO4)]∞, 2, and [Ag(L)(OAc)·2H2O]∞, 3, were prepared by layering the aqueous solution of the corresponding Ag(I) salt with L in ethanol, while [Ag(L′)(NO3)]∞, 4, and [Ag(L′)(ClO4)·H2O]∞, 5, were prepared by refluxing AgNO3 and AgClO4, respectively, with 2-amino-4,6-dimethylpyrimidine (L′) in H2O. Reaction of Ag2SO4 with L′ in methanol afforded the complex [Ag4(L′)2(SO4)2(H2O)4]∞, 6. In complex 1, the L ligands are coordinated to the Ag(I) metal centers in new tridentate fashions, forming 2-D pleated molecular sheets which are interlinked by the SO42− anions to form a 3-D layer structure. Complex 2 forms a pleated molecular sheet consisting of twenty four-membered metallocycles, involving six Ag ions which are bridged by six L ligands through the pyrimidyl nitrogen atoms. Complex 3 forms linear chains with sinusoidal geometry, which are interlinked through extensive Ag⋯Ag interactions (Ag⋯Ag = 3.102 Å) to form 2-D wavy rectangular grids. Complex 4 forms single-strained helical coordination polymers, which are interlinked through a series of Ag⋯O interactions (2.667 and 2.699 Å) to form 2-D chair like grids. The silver atoms of 5 are bound to the nitrogen atoms of two symmetry-related L′ ligands in a distinctly non-linear geometry, forming zigzag chains. The structure of 6 consists of clusters of the formula [Ag8(L′)4(SO4)4(H2O)8], which are interlinked through L′ ligands to form 2-D sheets. The μ1-O, μ2-O′- bonding mode of the SO42− anion in complex 6 is unique for Ag(I) complexes. Their thermal properties have been investigated by using differential scanning calorimetry (DSC) and thermogravimetric analyses (TGA)
Characterization of Functional Polymers by Temperature Programmed Pyrolysis-Mass Spectrometry. (1998)

A temperature programmed pyrolysis-mass spectrometric (TPPy-MS) system was developed for evolved gas analysis for polymeric materials. In this system, a temperature programmable micro-furnace pyrolyzer was directly coupled with a quadrupole mass spectrometer via a highly deactivated metal capillary. Thus developed system was applied to the following characterization of various functional polymers:a) Thermal degradation process of a flame-retarded poly(butylene terephthalate) (FR-PBT) with a synergistic flame-retardant system based on a brominated polycarbonate (Br-PC) and Sb2O3 was investigated. During the degradation of FR-PBT, the evolution of brominated phenols and HBr proved to be closely related to the synergistic effect of Sb2O3 on the decomposition of Br-PC in the flame retardant system. Furthermore, the evolution of the flame poisoning SbBr3 caused by the synergistic effect of Sb2O3 with Br-PC was also able to be monitored.b) Chitin derivative/poly(vinyl chloride) (PVC) blends were characterized mainly in terms of their miscibility and sites of the intermolecular interactions. Stepwise degradation apparently in three stages was commonly observed for the blends corresponding to the degradation of the respective blending polymers. However, each degradation peak temperature proved to change correlating to the miscibility of the blends. Moreover, during the dehydrochlorination stage for PVC at relatively lower temperatures below 300°C, the evolution of many characteristic products formed from the chitin derivative was also observed, suggesting that the intimate intermolecular interactions between the chitin derivative and PVC were triggering the degradation of the chitin derivatives which should be stable up to ca. 350°C.
Cytotoxicity of nonionic amphiphilic copolymers (2012)

The purpose of this study is to ascertain the relationship between the structure of an amphiphilic nonionic polymer and its toxicity for cells (cytotoxicity) growing in a culture. To this end, 16 polymers of different architectures and chemical structures are tested, namely, linear triblock copolymers of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronics); diblock copolymers of propylene oxide, ethylene oxide, and hyperbranched polyglycerol; alternating and diblock copolymers of ethylene oxide and dimethylsiloxane; and two surfactants containing linear (Brij-35) or branched (Triton X-100) aliphatic chains. Polymer-cell interaction is assayed in a culture medium in the absence of serum. Effective concentrations of the polymers causing 50% cell death, EC50, vary within three orders of magnitude. Toxic concentrations of the alternating copolymer, Triton X-100, and Brij-35 are lower than their CMC values. In contrast, all block copolymers, regardless of their chemical structures, become toxic at concentrations above the CMC; that is, they acquire cytotoxicity only in the micellar form. The EC50 values of the copolymers depend on their hydrophilic-liphophilic balance (HLB) through the following empirical formula: EC50 × 106 = 8.71 × HLB2.1. This relationship makes it possible to predict the cytotoxic concentration region of a block copolymer of a known structure.
A novel SIC-PIC iterative detector with turbo code under multipath Rayleigh fading MIMO channel (2005)

In the multiinput multioutput (MIMO) wireless communication system, especially in the V-BLAST, the received signal vectors detection is the crucial part that impacts the system performance. This paper introduces a new V-BLAST detector that can gain more diversity gain. This detector utilizes the successive interference canceling (SIC) and parallel interference canceling (PIC), during the iteration of SIC and PIC, turbo code is used to guarantee the reliability of PIC. Compared with other detection algorithm, this new iterative detector can enhance the receive diversity. This paper simulates the algorithm with OFDM modulation under multipath Rayleigh MIMO channel. From the simulation results, the system performance can be improved and the complexity of this iterative detector is very low.
Carotenoid composition in the fruits of black paprika (Capsicum annuum variety longum nigrum) during ripening (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarotenoid composition in the fruits of black paprika (Capsicum annuum variety longum nigrum) during ripeningJozsef. Deli, Zoltan. Matus, and Jozsef. SzabolcsCite this: J. Agric. Food Chem. 1992, 40, 11, 2072–2076Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/jf00023a008https://doi.org/10.1021/jf00023a008research-articleACS PublicationsRequest reuse permissionsArticle Views238Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tortuosity Triggers Platelet Activation and Thrombus Formation in Microvessels (2011)

Tortuous blood vessels are often seen in humans in association with thrombosis, atherosclerosis, hypertension, and aging. Vessel tortuosity can cause high fluid shear stress, likely promoting thrombosis. However, the underlying physical mechanisms and microscale processes are poorly understood. Accordingly, the objectives of this study were to develop and use a new computational approach to determine the effects of venule tortuosity and fluid velocity on thrombus initiation. The transport, collision, shear-induced activation, and receptor-ligand adhesion of individual platelets in thrombus formation were simulated using discrete element method. The shear-induced activation model assumed that a platelet became activated if it experienced a shear stress above a relative critical shear stress or if it contacted an activated platelet. Venules of various levels of tortuosity were simulated for a mean flow velocity of 0.10 cm s(-1), and a tortuous arteriole was simulated for a mean velocity of 0.47 cm s(-1). Our results showed that thrombus was initiated at inner walls in curved regions due to platelet activation in agreement with experimental studies. Increased venule tortuosity modified fluid flow to hasten thrombus initiation. Compared to the same sized venule, flow in the arteriole generated a higher amount of mural thrombi and platelet activation rate. The results suggest that the extent of tortuosity is an important factor in thrombus initiation in microvessels.
Full‐color photo‐addressable electronic paper using cholesteric liquid crystals and organic photoconductors (2008)

Abstract— Full‐color photo‐addressable electronic paper using cholesteric liquid crystals and organic photoconductors was developed. The electronic paper is comprised of two stacked photo‐addressable elements displaying blue/green and red images, respectively. Each photo‐addressable element was independently controlled by two different color‐addressing lights. Furthermore, blue and green images were selectively switched by one organic photoconductor using the threshold characteristics of cholesteric liquid crystals. A highly reflective polymer‐dispersed cholesteric liquid‐crystal (PDCLC) layer was obtained by a new formation process based on the sol‐gel transition behavior of a gelatin matrix and an agar overcoat layer. The PDCLC layer had a close‐packed honeycomb‐like monolayer structure with a flat surface. The A6‐sized prototype had paper‐like features and showed full‐color bistable images instantly written with a viewer‐type writing apparatus.
Monolithically integrated optical link using photonic crystal laser and photodetector (2013)

We have demonstrated monolithic integration of photonic crystal (PhC) laser and photodetector. By employing an embedded active region structure, PhC laser exhibits ultra-low threshold current. Integrated optical link exhibits ultra-low operating energy of 28.5 fJ/bit.
Cryptanalysis and improvement of an ID-based ad-hoc anonymous identification scheme at CT-RSA 05. (2005)

An ad-hoc anonymous identification scheme is a new multiuser cryptographic primitive that allows participants from a user population to form ad hoc groups, and then prove membership anonymously in such groups. Recently, Nguyen [11] proposed an ID-based ad-hoc anonymous identification scheme from bilinear pairings. However, in this paper, we propose an attack on Nguyen&apos;s ID-based ad-hoc anonymous identification scheme. We show that any one can impersonate a valid group member to perform the anonymous identification protocol successfully.
Delivery of Cas9 Protein into Mouse Zygotes through a Series of Electroporation Dramatically Increases the Efficiency of Model Creation (2016)

Previously we established Zygote Electroporation of Nucleases (ZEN) technology as an efficient and high-throughput way to generate genetically modified mouse models. However, there were significant variations of the targeting efficiency among different genomic loci using our previously published protocol. In this study, we improved the ZEN technology by delivering Cas9 protein into mouse zygotes through a series of electroporation. Using this approach, we were able to introduce precise nucleotide substitutions, large segment deletion and short segment insertion into targeted loci with high efficiency.
Optimization of Non-ATP Competitive CDK/Cyclin Groove Inhibitors through REPLACE-Mediated Fragment Assembly (2013)

A major challenge in drug discovery is to develop and improve methods for targeting protein-protein interactions. Further exemplification of the REPLACE (REplacement with Partial Ligand Alternatives through Computational Enrichment) strategy for generating inhibitors of protein-protein interactions demonstrated that it can be used to optimize fragment alternatives of key determinants, to combine these in an effective way, and this was achieved for compounds targeting the cyclin-dependent kinase 2 (CDK2) substrate recruitment site on the cyclin regulatory subunit. Phenylheterocyclic isosteres replacing a critical charge-charge interaction provided new structural insights for binding to the cyclin groove. In particular, these results shed light onto the key contributions of a H-bond observed in crystal structures of N-terminally capped peptides. Furthermore, the structure-activity relationship of a bis(aryl) ether C-terminal capping group mimicking dipeptide interactions was probed through ring substitutions, allowing increased complementarity with the primary hydrophobic pocket. This study further validates REPLACE as an effective strategy for converting peptidic compounds to more pharmaceutically relevant compounds.
Heat‐shocked Neuronal PC12 Cells Reveal Alzheimer's Disease—associated Alterations in Amyloid Precursor Protein and Tau (1993)

The Alzheimer's disease (AD) brain contains many abnormal protein modifications. These include the abnormal processing of amyloid precursor protein (APP) to form the amyloidogenic beta/A4 peptide and the abnormal phosphorylation of tau to form A68, the major constituent of the neurofibrillary tangle. In addition, many of the biochemical alterations found in the AD brain are also found in heat-shocked or stressed cells. We used heat-shocked neuronal PC12 cells to investigate the effects of stress on APP and tau. We found that by simply exposing neuronal PC12 cells to an elevated temperature (45 degrees C) for 30 minutes, they exhibited several features characteristic of the heat shock response. These included a 45% reduction in total protein synthesis, the induction of heat shock protein (hsp) 72, and increased phosphorylation of the protein synthesis initiation factor eIF-2 alpha. The heat-shocked cells also exhibited alterations in the metabolism and phosphorylation of APP. Under heat shock conditions, we found two additional APP-like polypeptides not present in controls and a significant decrease in the phosphorylation state of APP. We also found that an A68-like protein is formed in neuronal PC12 cells when subjected to elevated temperature. This A68-like protein was formed with heat shock even in the absence of protein synthesis, suggesting that its production occurred post-translationally. The tau/A68 polypeptides were identified as phosphoproteins, and the phosphorylation of tau to form A68 was reversed with recovery of the cells from heat shock. Immunoprecipitation of lysates from heat shocked cells with antibodies to hsp72/73 resulted in co-precipitation of tau, but not A68 with hsp72 indicating a stable complex formation between these two proteins. These results suggest that heat shock proteins may play either a protective or promoting role in the formation of A68 and/or the amyloidogenic C-terminal fragment of APP.
An ultrasensitive and low-cost graphene sensor based on layer-by-layer nano self-assembly (2011)

The flexible cancer sensor based on layer-by-layer self-assembled graphene reported in this letter demonstrates features including ultrahigh sensitivity and low cost due to graphene material properties in nature, self-assembly technique, and polyethylene terephthalate substrate. According to the conductance change of self-assembled graphene, the label free and labeled graphene sensors are capable of detecting very low concentrations of prostate specific antigen down to 4 fg/ml (0.11 fM) and 0.4 pg/ml (11 fM), respectively, which are three orders of magnitude lower than carbon nanotube sensors under the same conditions of design, manufacture, and measurement.
Low Temperature Scanning Force Microscopy of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>Si</mml:mi><mml:mo>(</mml:mo><mml:mn>111</mml:mn><mml:mo>)</mml:mo><mml:mi>−</mml:mi><mml:mo>(</mml:mo><mml:mn>7</mml:mn><mml:mo>×</mml:mo><mml:mn>7</mml:mn><mml:mo>)</mml:mo></mml:math>Surface (2000)

A low temperature scanning force microscope (SFM) operating in a dynamic mode in ultrahigh vacuum was used to study the Si(111)- (7x7) surface at 7.2 K. Not only the twelve adatoms but also the six rest atoms of the unit cell are clearly resolved for the first time with SFM. In addition, the first measurements of the short range chemical bonding forces above specific atomic sites are presented. The data are in good agreement with first principles computations and indicate that the nearest atoms in the tip and sample relax significantly when the tip is within a few A of the surface.
Jacques Allain/Isabelle Fauduet/Marie Tuffreau-Libre, La necropole gallo-romaine du «Champ de l’Image» ä Argentomagus (Saint-Marcel, Indre) suivid’uneetude sur la necropole des «Ripottes» (2019)

Rezension zu: Jacques Allain/Isabelle Fauduet/Marie Tuffreau-Libre, La necropole gallo-romaine du «Champ de l’Image» ä Argentomagus (Saint-Marcel, Indre) suivid’uneetude sur la necropole des «Ripottes». Avec la collaboration de R. Albert, V. Arveiller-Dulong, L. Brissaud, L. Chaix, S. Deyts, B. Fischer, C. et J. Lorenz, G. Patry, P. Pinon, Th. Poulain-Josien, J.-L. Roche, M. Rouvier-Jeanlin. Memoire I du Musee d’Argentomagus = 3C Supplement ä la Revue Archeologique du Centre de la France, Saint-Marcel 1992. ISBN 2-909184-00-5. 240 Seiten mit 104 Abbildungen, 24 Tabellen und zahlreichen Katalogabbildungen