gebhart/patrepeval huggingface dataset:
Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. (1992)

The effect of fish oil on the course of ulcerative colitis was investigated in a randomised blinded controlled study. Eighty seven patients received supplements of 20 ml HiEPA fish oil as triglyceride (4.5 g of eicosapentaenoic acid) or olive oil placebo daily for one year. The oils were given in addition to standard drug therapy and trial entry was stratified for disease activity. Fish oil significantly increased the eicosapentaenoic acid content of rectal mucosa to 3.2% of total fatty acids at six months, compared with 0.63% for patients on olive oil. This was associated with increased synthesis of leukotriene B5, and 53% suppression of leukotriene B4 synthesis by ionophore--stimulated neutrophils. Leukotriene B4 suppression persisted for at least two months after treatment was stopped. Treatment with fish oil resulted in measurable, but only limited clinical benefit. For patients entering the trial in relapse (n = 53), there was a significant reduction in corticosteroid requirement after one and two months treatment. There was a trend towards achieving remission (off corticosteroids) faster in the patients on fish oil, although differences were not significant. For patients in remission at trial entry or during the trial (n = 69), there was no significant difference in the rate of relapse by log rank analysis. We conclude that fish oil supplementation produces a modest corticosteroid sparing effect in active disease, but there is no benefit in maintenance therapy.
Job Scheduling Optimization of High Performance Computing in Biological Gene Sequencing Based on Workload Analysis (2017)

Mining job scheduling features based on extraction and analysis of workload trace in high performance computing clusters can be used to optimize scheduling strategy and enhance system performance. Based on detailed analysis of workload trace from a gene sequencing high performance computing system, this paper proposes a multi-queue backfilling scheduling algorithm, which is based on traditional backfilling scheduling. While optimizing for memory resource demands, this algorithm provides queue level load balancing to deal with the innate load imbalance characteristics of high performance systems. Experimental results based on practical gene sequencing workload trace clearly demonstrate that compared with traditional scheduling algorithms, the algorithm proposed in this paper is a good strategy to reduce the job waiting time and improve resource utilization.
A New Simple Method of Preparing Actin from Chicken Gizzard1 (1985)

A simple method for preparing actin from chicken gizzard was described. This method takes advantage of a property of gizzard tropomyosin, that is, that it does not form Mg paracrystals readily.
Polymers with Inherent Microporosity (2011)

This chapter contains sections titled: Introduction Hypercrosslinked Polymers Polymers of Intrinsic Microporosity Covalent Organic Frameworks Conclusions References
XBP1 is Critical to Protect Cells from Endoplasmic Reticulum Stress: Evidence from Site-2 Protease-deficient Chinese Hamster Ovary Cells (2006)

XBP1 is a transcription factor downstream of IRE1, a transmembrane protein in the endoplasmic reticulum (ER) which functions as a sensor and transducer of ER stress. XBP1 mRNA is constitutively expressed at a low level as an intron-containing precursor mRNA (unspliced mRNA), which is subject to IRE1-mediated splicing reaction upon ER stress to produce the active form of XBP1, pXBP1(S). Because the XBP1 promoter carries a perfect ER stress-response element, namely, the cis-acting element responsible for the induction of ER chaperones, and XBP1 mRNA is induced in response to ER stress with a time course similar to that of ER chaperone mRNAs, it is conjectured that transcription factor ATF6, activated immediately upon ER stress, induces the transcription of not only ER chaperone genes but also of XBP1 gene, such that pXBP1(S) produced by the splicing of an increased level of XBP1 mRNA escapes from proteasome-mediated degradation. Here, we examined this notion by determining the induction of XBP1 mRNA and pXBP1(S) in mutant Chinese hamster ovary (M19) cells deficient in Site-2 protease, which executes the last step of ER stress-induced activation of ATF6. We found that the induction of XBP1 mRNA and pXBP1(S) was greatly reduced in M19 cells as compared with wild-type cells, leading to a marked reduction in the extent of induction of XBP1-target gene. M19 cells were much more sensitive to ER stress than wild-type cells. Importantly, overexpression of XBP1 unspliced mRNA in M19 cells reversed all of these phenotypes. We concluded that ATF6-mediated induction of XBP1 mRNA is important to the production of pXBP1(S), activation of XBP1-target genes, and protection of cells from ER stress.
Use of fire in land clearing: Selection and preparation of the area to be cleared by planned application and confinement of fire important (1951)

The second of five articles reporting the findings in investigations in the effectiveness, the safety and the cost of the use of controlled burning as a tool for land clearing. No attempt is made to provide one formula for prescribed burning in California; each fire is an individual case to be planned at site of burn.
New program for new times - Pre-service teacher education at QUT (2003)

The Faculty of Education at Queensland University of Technology has engaged in a process of reconceptualising its pre-service teacher education programs; and 2003 has seen the implementation of the first year of the new four-year Bachelor of Education program. The process of reconceptualisation led initially to a vision statement, which reads in part: The vision of this reconceptualised course is to graduate pre-service teacher education students who are: life long learners who possess a strong knowledge of the content and discourses of the disciplines from which their projected teaching areas are derived, and who will be able to contribute to the framing of new knowledge communities and areas of inquiry high level thinkers, capable of understanding the complex knowledges that shape the work of educators, particularly in reference to how students engage in high quality learning, and educators who actively reflect upon and investigate the dynamic socio-cultural and socio-political constructs in which their work is embedded. The course is designed to graduate beginning teachers and educators who are well respected in their field through their professional work, commitment to learning, expertise in current curriculum knowledge and leadership, refined repertoire of pedagogical practices, skills in knowledge facilitation and the construction of diverse, culturally-responsive learning environments that best facilitate enhanced learning for a variety of learners....
A Reliable CMOS Receiver for Power Line Communications in Integrated Circuits (2012)

Power line communications (PLC) in integrated circuits (ICs) was proposed by Dr. Dong S. Ha's group in 2005. Their goal was to utilize the power distribution network for data communications as well as delivery of power, so that the routing overhead can be avoided and the number of pins in the chip can be reduced. Dr. Ha's group demonstrated through measurements the existence of pass-bands in the power distribution networks and the feasibility of power line communications in ICs. Several PLC receivers were developed to recover data superimposed on the power lines of an IC. This thesis research investigated a new PLC receiver to improve shortcomings of previous PLC receivers, specifically to improve the reliability while reducing power dissipation. The proposed PLC system adopts an amplitude shift keying (ASK) modulation to transmit and detect data through power distribution networks. The proposed PLC receiver consists of three main sub-blocks. The first sub-block is a level shifter, which lowers the offset voltage of the supply voltage to approximately 0.5VDD. The second sub-block is a signal extractor, which detects a data signal superimposed on the power line. The signal extractor is a differential amplifier, in which one input is connected through an RC low-pass filter. The DC voltage of the data signal varies in accordance with the supply voltage fluctuations and droop. The low-pass filter intends to pass only the DC term of the data signal. Since the DC voltage is common for both inputs of the differential amplifier, it is removed from the data signal through the common mode rejection of the differential amplifier. Therefore, the signal extractor can mitigate supply voltage fluctuations and droops. The last sub-block is the logic restorer, which converts the differential signal to a logic value based on a Schmitt trigger. The hysteresis of the Schmitt trigger improves the noise immunity of the receiver The proposed PLC receiver is designed and fabricated in CMOS 0.18 µm technology under the supply voltage of 1.8 V. Measurement results of the three sub-blocks and the entire PLC receiver are presented and compared with simulation results. The data rate for the measurements is set to 10.0 Mbps, and the ASK modulation scheme adopts VDD (= 1.8 V) for logic 0 and 90 mV above VDD for logic 1. The measurements show that the PLC receiver can tolerate the supply voltage drop by 0.423 V or 23.0%. The power dissipation for the receiver is 3.2 mW under 1.8 V supply. The core area of the receiver is 72.2 µm x 74.9 µm.
Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands (2019)

Androgen receptor (AR) is a validated therapeutic target for the treatment of metastatic castration-resistant prostate cancer (mCRPC). We report herein our design, synthesis, and biological characterization of highly potent small-molecule proteolysis targeting chimera (PROTAC) AR degraders using a potent AR antagonist and E3 ligase ligands with weak binding affinities to VHL protein. Our study resulted in the discovery of <b>11</b> (ARD-266), which effectively induces degradation of AR protein in AR-positive (AR+) LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC<sub>50</sub> values of 0.2-1 nM. ARD-266 is capable of reducing the AR protein level by >95% in these AR+ prostate cancer cell lines and effectively reduces AR-regulated gene expression suppression. For the first time, we demonstrated that an E3 ligand with micromolar binding affinity to its E3 ligase complex can be successfully employed for the design of highly potent and efficient PROTAC degraders and this finding may have a significant implication for the field of PROTAC research.
Strain-Dependent Differences in Murine Susceptibility to Coccidia (1979)

Differences in susceptibility of strains of mice to Eimeria ferrisi were observed by infecting eight strains of mice with six infectious dose levels and comparing the mortality rate among the strains for a period of 12 days. Mice of the C57BL/6 and HA/ICR strains were susceptible, and those of A/He, AKR, BALB/c, CBA, C3H/Anf, and DBA/2 strains were resistant to coccidial infection. Resistance was a dominant genetic expression, as indicated by the resistant response of F(1) hybrids of susceptible C57BL/6 and resistant CBA, C3H/Anf, or DBA/2 strains. An E. ferrisi infection in congenitally athymic nu/nu mice and phenotypically normal heterozygous nu/+ mice was used to determine how thymus-dependent immunoincompetence in cell-mediated immunity of the nu/nu mouse affected resistance to infection in a genetic background of the resistant BALB/c mouse. Results of primary and challenge infections in these two strains of mice suggested that resistance is thymus dependent. Furthermore, impairment of thymus-dependent cell-mediated immunity in resistant AKR mice by treatment with mouse antithymus serum led to partial susceptibility. However, susceptible C57BL/6 and HA/ICR strains are phenotypically normal mice, and previous evidence showed that C57BL/6 mice are not completely immunoincompetent in cell-mediated reactivity to coccidia. Collectively, our data show that cell-mediated immunity is necessary for resistance but may be subjected to modification by genetic expression of the host. The possible role of immune response genes in the control of coccidial immunity is discussed.
Text Mining in Organizational Research (2017)

Despite the ubiquity of textual data, so far few researchers have applied text mining to answer organizational research questions. Text mining, which essentially entails a quantitative approach to the analysis of (usually) voluminous textual data, helps accelerate knowledge discovery by radically increasing the amount data that can be analyzed. This article aims to acquaint organizational researchers with the fundamental logic underpinning text mining, the analytical stages involved, and contemporary techniques that may be used to achieve different types of objectives. The specific analytical techniques reviewed are (a) dimensionality reduction, (b) distance and similarity computing, (c) clustering, (d) topic modeling, and (e) classification. We describe how text mining may extend contemporary organizational research by allowing the testing of existing or new research questions with data that are likely to be rich, contextualized, and ecologically valid. After an exploration of how evidence for the validity of text mining output may be generated, we conclude the article by illustrating the text mining process in a job analysis setting using a dataset composed of job vacancies.
Comparison of the Matrix and DC-link Converter Topologies in a Hybrid Electric Vehicle (2003)

<div class="htmlview paragraph">Both the Matrix and the DC-link converters have qualities making each attractive in a Hybrid Electric Vehicle (HEV) application. This paper compares some of the advantages and disadvantages of each approach when used in a conceptual 13.6 Kg (15-ton), six-wheeled, combat HEV. This system consisting of a compact, 300 kW, 30 Krpm, permanent magnet synchronous generator, battery storage, and six, 42 kW, permanent magnet traction motors. Due to the confided space of the HEV, the key criterion in the motor drive selection process was determining which presented the minimum system volume. Our study compares the active components count, the size of the reactive components, and power routing topologies.</div>
Comparison of naming schema in ICN (2016)

Information-Centric Networking (ICN) treats content as a first-class entity - each content has a unique identity and ICN routers forward traffic based on content identity rather than the locations of the content. This provides benefits like dynamic request routing, caching and mobility support. The choice of naming schema (flat vs. hierarchical) is a fundamental design choice in ICN which determines the functional separation between the network layer and the application layer. With hierarchical names, the network layer is cognizant of the semantics of hierarchical names. Name space management is also part of network layer. ICN architectures using flat names leave these to the application layer. The naming schema affects the performance and scalability of the network in terms of forwarding efficiency, routing table size and name space size. This paper provides both qualitative and quantitative comparison on the two naming schemas using these metrics, noting that they are interdependent. We seek to understand which naming schema would be better for a high-performance, scalable ICN architecture.
'Toxic strep syndrome'. A manifestation of group A streptococcal infection (1988)

• Three patients presented with multisystem disease that shared many of the features of toxic shock syndrome. Bacteriologic and serologic evidence strongly suggested that group A β-hemolytic<i>Streptococcus</i>had caused the illnesses. Group A streptococcal infection may be an underdiagnosed cause of a toxic streptococcal syndrome, a syndrome of multisystem disease apparently mediated by toxins. (<i>Arch Intern Med</i>1988;148:1421-1424)
Heart Rate Turbulence after Ventricular and Atrial Premature Beats in Subjects without Structural Heart Disease (2003)

HR behavior is different in response to APBs and VBPs among subjects without structural heart disease. Different definitions and calculation formulas should be used in the analysis of HR turbulence after APBs and VPBs.
Strategies for the Controlled Electronic Doping of Colloidal Quantum Dot Solids (2015)

Over the last several years tremendous progress has been made in incorporating colloidal quantum dot (CQD) solids as photoactive components in optoelectronic devices. A large part of this progress is associated with significant advancements made in controlling the electronic doping of CQD solids. Today, a variety of strategies exists towards that purpose; this Minireview aims to survey the major published works in this subject. Additional attention is given to the many challenges associated with the task of doping CQDs, as well as to the realization of optoelectronic functionalities and applications upon successful light and heavy electronic doping of CQD solids.
IDIOPATHIC POLYPOIDAL CHOROIDAL VASCULOPATHY (IPCV) (1990)

Eleven patients, 40 to 71 years old, had a choroidal vasculopathy that led to hemorrhagic and exudative macular degeneration. The patients had peculiar polypoidal, subretinal, vascular lesions associated with serous and hemorrhagic detachments of the retinal pigment epithelium. This macular disorder, which we have named idiopathic polypoidal choroidal vasculopathy (IPCV), appears to represent a distinct entity that differs clinically and demographically from age-related macular degeneration (AMD) and other macular diseases associated with subretinal neovascularization. Recognition of this condition is important because it may have specific risk factors, natural course, and management considerations that differ from those of age-related macular degeneration.
Pharmacokinetics and metabolism of gabapentin in rat, dog and man. (1986)

This paper describes the pharmacokinetic studies of 1-(aminomethyl)-cyclohexane acetic acid (gabapentin, Gö 3450, CI-945) conducted with the 14C-labelled substance following intravenous and intragastric administration to rats and dogs and oral administration to humans. Gabapentin is well absorbed in rats, dogs and in humans, with maximum blood levels, reached within 1-3 h after peroral administration. Following i.v. administration to rats, similar blood and brain levels of gabapentin are observed after a short distribution phase, whereby concentrations in cerebrum and cerebellum are comparable. The highest concentrations are found in the pancreas and kidneys and the lowest values in adipose tissue. No binding of gabapentin to human plasma proteins or human serum albumin is observed. The distribution coefficient (octanol/buffer pH 7.4) is 7.5 X 10(-2). In man, no biotransformation of gabapentin is observed. In rats, biotransformation is only minor. In dogs, however, a remarkable formation of N-methyl-gabapentin is found. Elimination half-lives range between 2-3 h in rats, 3-4 h in dogs, and 5-6 h in man. Gabapentin is nearly exclusively eliminated via the kidneys. Renal elimination was up to 99.8% in rats and approx. 80% in man following oral administration. The blood level-time course after i.v. administration to rats can well be described by a three-compartment open model. Experiments in rats and dogs demonstrate that pharmacokinetics are not sex-dependent and are not changed after multiple dosage. Pharmacokinetics are shown to be linear in the range tested of 4 to 500 mg/kg i.v. in rats.
High similarity of IgG antibody profiles in blood and saliva opens opportunities for saliva based serology (2019)

Saliva based diagnostics is a rapidly evolving field due to the large diagnostic potential and simple sample collection. Currently only few individual molecules were investigated for their diagnostic capabilities in saliva. A systematic comparison of IgG antibody profiles in saliva and plasma is still missing in scientific literature. Our hypothesis is that IgG profiles in plasma and saliva are highly similar for each individual. As a consequence, one could implement practically any plasma based IgG assay (classical serology) as saliva based assay. In other words, the IgG antibodies found in blood are also accessible from saliva. We confirm our hypothesis by comparing IgG reactivities towards protein and peptide antigens. We isolated saliva IgG with high purity and demonstrate that plasma IgG reactivities (classical serology) can be inferred from saliva. As a showcase we perform Hepatitis B virus antibody (plasma-)titer determination from saliva. Additionally we show that plasma and saliva IgG profiles of 20 individuals are highly similar for 256 peptide antigens and match (unsupervised) with high probabilities. Finally, we argue for generalisation to the complete IgG antibody profile. The presented findings could contribute greatly to the development of saliva based diagnostic methods of numerous antibody based tests.
Electrochemical carbon nanotube filters for water and wastewater treatment (2016)

Abstract Electrochemically active carbon nanotube (CNT) filters have been developed as a highly efficient technology for water and wastewater treatment during the last few years. CNT filters have been widely used to adsorb chemical and biological contaminants due to their high stability, great flexibility, and large specific surface area. Electrochemically active CNT filters provide additional electrooxidation of the adsorbed contaminants and have been proven to be a highly effective treatment technology in a few recent lab-scale studies. The working principles, impacting factors, and some of the latest development of electrochemically active CNT filters are reviewed in this paper. The existing challenges and future perspectives are also discussed.
Incorporation of Single Fiber Reflectance Spectroscopy into Ultrasound-Guided Endoscopy (EUS-FNA) of Mediastinal Lymph Nodes (2010)

We have incorporated a single fiber reflectance spectroscopy device into the EUS-FNA procedure. Here, we present quantitative metrics that describe the vascular physiology within normal and metastatic lymph nodes in patients undergoing EUS-FNA.
A conifer genomics resource of 200,000 spruce (Picea spp.) ESTs and 6,464 high-quality, sequence-finished full-length cDNAs for Sitka spruce (Picea sitchensis) (2008)

This paper provides detailed annotation and quality assessment of a large EST and FLcDNA resource for spruce. The 6,464 Sitka spruce FLcDNAs represent the third largest sequence-verified FLcDNA resource for any plant species, behind only rice (Oryza sativa) and Arabidopsis (Arabidopsis thaliana), and the only substantial FLcDNA resource for a gymnosperm. Our emphasis on capturing FLcDNAs and ESTs from cDNA libraries representing herbivore-, wound- or elicitor-treated induced spruce tissues, along with incorporating normalization to capture rare transcripts, resulted in a rich resource for functional genomics and proteomics studies. Sequence comparisons against five plant genomes and the non-redundant GenBank protein database revealed that a substantial number of spruce transcripts have no obvious similarity to known angiosperm gene sequences. Opportunities for future applications of the sequence and clone resources for comparative and functional genomics are discussed.
Prothrombin time is predictive of low plasma prothrombin concentration and clinical outcome in patients with trauma hemorrhage: analyses of prospective observational cohort studies (2017)

Admission PT is predictive of low prothrombin concentration and clinical outcome. PT could therefore be used as a surrogate for prothrombin concentration and further evaluation of point-of-care devices for faster PT analysis is warranted.