gebhart/patrepeval huggingface dataset:
Characteristics of Selenazolidine Prodrugs of Selenocysteine:  Toxicity and Glutathione Peroxidase Induction in V79 Cells (2003)

Novel selenazolidine prodrugs of selenocysteine are being developed as potential selenium delivery agents for cancer chemoprevention and other clinical uses. The 2-unsubstituted compound, selenazolidine-4(R)-carboxylic acid (L-SCA), and the 2-oxo- and 2-methyl analogues possessing D-stereochemistry (D-OSCA and D-MSCA, respectively) were synthesized and chemically characterized. L/D pairs, along with other organoselenium compounds and common inorganic forms, were studied in cultured V79 cells to understand their inherent toxicity and their ability to induce selenium-dependent glutathione peroxidase (GPx) activity, which indicates the provision of biologically available selenium. All of the selenazolidines were much less toxic to the cells than was sodium selenite (IC(50) approximately 17 microM) or the parent selenolamines, L- or D-selenocystine (IC(50) approximately 34 or 39 microM, respectively); OSCA was less toxic than MSCA. The stereoisomers of OSCA produced very different IC(50) values (L-OSCA, approximately 451 microM; D-OSCA, >3000 microM), while the IC(50) values derived for the stereoisomers of MSCA were of the same order of magnitude (L-MSCA, approximately 79 microM; D-MSCA, approximately 160 microM). Compounds possessing L-stereochemistry were at least as active with respect to GPx induction as was sodium selenite (2.2-fold increase at 15 microM). L-Selenocystine produced a 4.2-fold increase in GPx activity at 30 microM, while L-SCA produced a 5.9-fold increase, followed by L-OSCA (4.6-fold) and L-MSCA (2.1-fold), all at 100 microM. Compounds possessing D-stereochemistry showed minimal ability to induce GPx activity (D-selenocystine, 1.0-fold increase; D-OSCA, 1.4-fold increase; D-MSCA, 1.3-fold increase).
Miltefosine Treatment of<i>Leishmania major</i>Infection: An Observational Study Involving Dutch Military Personnel Returning from Northern Afghanistan (2009)

In a retrospective, observational study involving 34 patients with Leishmania major infection, 31 of whom had experienced unsuccessful treatment with intralesional antimony (ilSb(v)), miltefosine proved effective. Thirty patients experienced cure after receipt of miltefosine, 3 after receipt of additional ilSb(v), and 1 after 28 daily intravenous injections of antimony. Temporary diminution of ejaculate volume was reported by 21 patients.
Injection laser half adder (1967)

A functional device with the logic operation of a half adder using optical coupling in a single unit of the injection laser was fabricated. The mechanism of the operation is described and the results at 77° are shown.
Two‐Dimensional Computer Modelling of Polycrystalline Film Growth (1991)

Polycrystalline thin films, deposited from a vapour phase, often show a columnar morphology. We present computer simulations of a 2D model of the polycrystalline growth process. The model consists of randomly oriented squares, growing from a line. We find, that the characteristic length scale < Δ x > of the growing surface (average edge length projected on the substrate) diverges as a function of time according to a power law < x > ∼ t p , with p ≈ 0.52.
A two probes scanning phaseless near-field far-field transformation technique (1999)

An innovative and effective technique to determine the far-field of a radiating system from near-field intensity data is introduced, analyzed, and tested. The approach is based on the simultaneous measurement of the amplitude of the voltages received by two different probe antennas moving over a single scanning surface in the near zone and performs the phase retrieval of the near-field by assuming as unknown the plane wave spectrum of the field. The radiated field is then straightforwardly evaluated. As compared to the existing phaseless measurement techniques, the use of two different probes makes it possible to avoid the need for a second scanning surface and thus allows the use of smaller (and cheaper) anechoic chambers. Furthermore, the measurement time is essentially equal to that required by conventional techniques based on the measurement of the complex near-field. The reliability and the effectiveness' of the approach are investigated and discussed and the key factors affecting its behavior are highlighted. In particular, the relevance of the difference between the plane wave spectra (PWS) of the two probe antennas in ensuring an acceptable reliability of the solution, with respect to the starting point of the procedure, is outlined. Finally, the effectiveness of the approach is confirmed by an extensive numerical analysis, which also shows the stability of the solution against data noise.
In Situ Controllable Loading of Ultrafine Noble Metal Particles on Titania (2009)

Herein we present a novel and facile approach to controllably load ultrafine noble metal nanoparticles on titania through in situ redox reaction between the reductive titanium(III) oxide support and metal salt precursors in aqueous solution. A series of noble metal/TiO(2) nanocomposites with uniform metal dispersion, tunable metal particle size, and narrow metal particle size distribution were obtained.
The diffusion of gases and water vapor through grafted polyoxymethylene (1970)

Abstract Polyoxymethylene was successfully grafted with styrene, butadiene, and acrylonitrile by the mutual irradiation method in the monomer containing 18% of dimethyl formamide. The CO 2 and water vapor permeabilities and diffusivities were determined in the case of the butadiene‐ and acrylonitrile‐grafted products. The former grafts had higher permeabilities than the ungrafted materials. However, the acrylonitrile grafts showed considerably reduced water vapor permeability and diffusivity compared to the ungrafted polyoxymethylene. Films made by grafting to polymer powder and compression molding showed lower permeabilities compared to those made by direct grafting to polyoxymethylene films.
Reversible Watermarking for Digital Audio Based on Cochlear Delay Characteristics (2011)

There have recently been serious social issues involved in multimedia signal processing such as digital rights management, secure authentication, malicious attacks, and tampering with digital audio/speech signals. Reversible watermarking is a technique that enables these signals to be authenticated and then restored to their original signals by removing watermarks from them. We previously proposed an inaudible digital-audio watermarking approach based on cochlear delay (CD). We investigated how the proposed approach could be developed as reversible watermarking by considering blind detection for inaudible watermarks and the reversibility of audio watermarking. We evaluated inaudible and reversible watermarking with the proposed approach by carrying out three objective tests (PEAQ, LSD, and bit-detection or SNR). The results revealed that reversible watermarking based on CD could be accomplished.
InGaAsP/InP strained MQW laser with integrated mode size converter using the shadow masked growth technique (2002)

We have successfully integrated a mode size converter with a PBH strained MQW InGaAsP/InP laser diode using the SMG technique. The laser performance is hardly affected by the taper integration. Due to the taper, the coupling loss to a cleaved fibre is reduced from 9.3 dB for a non-tapered laser to 3.3 dB for a laser with a 200 /spl mu/m taper.
Fault-Tolerant Software (1979)

Limitations in the current capabilities for verifying programs by formal proof or by exhaustive testing have led to the investigation of fault-tolerance techniques for applications where the consequence of failure is particularly severe. Two current approaches, N-version programming and the recovery block, are described. A critical feature in the latter is the acceptance test, and a number of useful techniques for constructing these are presented. A system model for the recovery block is introduced, and conclusions derived from this model that affect the design of fault-tolerant software are discussed.
Metal oxides as heterogeneous catalysts for oxygen evolution under photochemical conditions (1988)

Metal oxides, in the form of dispersed powders, have been tested as potential catalysts for the four-electron oxidation of water to O2 under photochemical conditions. The most efficient catalysts were found to be IrO2, Co3O4, RuO2, NiCo2O4, Rh2O3 and Mn2O3 and, in particular, high activity was observed with IrO2. Comparison of the oxide structure with its observed rate of O2 generation under standard conditions has allowed formulation of a few general requisites for an effective catalyst. Samples of iridium oxide deposited onto the surface of a second (inert) oxide were tested for their O2-evolving capability. The efficiency of the system depended markedly upon the nature of the support. Materials that favour formation of small deposits of iridium oxide (e.g. ZnO, MgO, TiO2) are the best supports, whilst O2 production is almost completely inhibited with acidic supports. Many metal oxides can be prepared in the form of hydrates of variable composition. These materials also function as O2-evolving catalysts, the efficiency of the process depending upon any thermal pretreatment. This finding is explained in terms of changes in structure and composition of the oxide that occur upon heating.
Isolation and characterization of the Arabidopsis <i>heat‐intolerant 2</i> (<i>hit2</i>) mutant reveal the essential role of the nuclear export receptor EXPORTIN1A (XPO1A) in plant heat tolerance (2010)

*The Arabidopsis heat-intolerant 2 (hit2) mutant was isolated on the basis of its impaired ability to withstand moderate heat stress (37 degrees C). Determination of the genetic mutation that underlies the hit2 thermosensitive phenotype allowed better understanding of the mechanisms by which plants cope with heat stress. *Genetic analysis revealed that hit2 is a single recessive mutation. Map-based cloning was used to identify the hit2 locus. The response of hit2 to other types of heat stress was also investigated to characterize the protective role of HIT2. *hit2 was defective in basal but not in acquired thermotolerance. hit2 was sensitive to methyl viologen-induced oxidative stress, and the survival of hit2 seedlings in response to heat stress was affected by light conditions. The mutated locus was located at the EXPORTIN1A (XPO1A) gene, which encodes a nuclear transport receptor. Two T-DNA insertion lines, xpo1a-1 and xpo1a-3, exhibited the same phenotypes as hit2. *The results provide evidence that Arabidopsis XPO1A is dispensable for normal plant growth and development but is essential for thermotolerance, in part by mediating the protection of plants against heat-induced oxidative stress.
Supporting mobile multimedia services with intermittently available grid resources (2003)

Abstract. Advances in high quality digital wireless networks and differentiated services have enabled the development of mobile multimedia applications that can execute in global infrastructures. In this paper, we introduce a novel approach to supporting mobile multimedia services by effectively exploiting the intermittently available idle computing, storage and communication resources in a Grid infrastructure. Specifically, we develop efficient resource discovery policies that can ensure continuous access to information sources and maintain application Quality-of-Service (QoS) requirements, e.g. required network transmission bandwidth on the mobile clients. Our performance studies indicate that mobility patterns obtained via tracking or user-supplied itineraries assist in optimizing resource allocation. The proposed policies are also resilient to dynamic changes in the availability of grid resources. 1
Relato de experiência de ensino da disciplina Assistência de Enfermagem ao Adulto I na zona rural (1985)

O estudo relata uma experiência de ensino-aprendizagem da disciplina Assistência de Enfermagem ao Adulto I, da Escola de Enfermagem da Universidade Federal do Rio Grande do Sul, cuja metodologia utilizada está centrada no aluno e cliente. A experiência de ensino utiliza como um dos campos de estágio, a localidade de Itapuã, onde a Universidade desenvolve atividades multidisciplinares no programa de integração Universidade/Comunidade - Projeto Itapuã.
Epinephrine Increases the Severity of Postresuscitation Myocardial Dysfunction (1995)

In an established rodent model after resuscitation following cardiac arrest, epinephrine significantly increased the severity of postresuscitation myocardial dysfunction and decreased duration of survival. More selective alpha-adrenergic agonist or blockade of beta 1-adrenergic actions of epinephrine reduced postresuscitation myocardial impairment and prolonged survival.
Fuel Cooling Needs for Advanced Diesel Engines (1997)

<div class="htmlview paragraph">Recent design changes in high pressure diesel injection pumps have increased the heat input to the fuel beyond acceptable levels. This paper will discuss the source of the extra heat, its effects, and various ways of dissipating it. The advantages and limitations of the various methods of fuel cooling are explained.</div>
FEM Analysis of Plough Feeder Interactions (1992)

Plough feeders are extensively used in major handling systems to extract bulk solids from bins and stockpiles to conveyors. Essentially the design of the plough blade drive mechanism is controlled by the maximum torque which occurs at start-up. Using current design procedures this torque is evaluated by scaling the steady state running torque using a rule-of-thumb scaling factor based on previous experience and crude empirical correlations. In view of the significant capital cost of these units and their key function in materials handling flow systems accurate predictions of the start-up torque are necessary. These predictions are possible using methods to analyse the complex coal blade interaction present during plough start-up. It will be shown that, by incorporation of suitable non linear constitutive equations for the interacting bulk material, anticipated qualitative graphical data results. This accuracy is dependent on the mesh of nodes, material properties and the assumed form of the strain or load generation mechanism. These considerations will be highlighted by reference to a plough extracting brown coal whose properties are emulated by a homogeneous material with a non-linear stress-strain relationship. The paper will conclude by identifying further non-linear finite element analysis underway and the need for model refinements.
Interactive vision-based intelligent system for active macfouling and microfouling detection on hull (2016)

A system to detect macfouling and microfouling on the ship hull is always challenging. The proposed system uses computer vision to analyze types and amount of fouling on the hull for subsequent analysis. The graphical-user-interface in a mobile microprocessor can be accessed and remotely controlled using platforms such as Windows and Android phone. Experiments have been tested on 40 different fouling images. The results show a mean accuracy of the fouling detection of approximately 79.97%, median of around 84.20% and a standard deviation of about 18.49% followed by the underwater experiments that give a static error of approximately 0.35% of the test area.
LycoRed as an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers: A randomized controlled clinical trial (2006)

Both HRT and LycoRed had a favorable effect on serum lipids and oxidative stress markers which were comparable. LycoRed can be used as an alternative to HRT to reduce the risk of atherosclerosis in postmenopausal women.
Analysis of secreted proteins from <b><i>Aspergillus flavus</i></b> (2005)

MS/MS techniques in proteomics make possible the identification of proteins from organisms with little or no genome sequence information available. Peptide sequences are obtained from tandem mass spectra by matching peptide mass and fragmentation information to protein sequence information from related organisms, including unannotated genome sequence data. This peptide identification data can then be grouped and reconstructed into protein data. In this study, we have used this approach to study protein secretion by Aspergillus flavus, a filamentous fungus for which very little genome sequence information is available. A. flavus is capable of degrading the flavonoid rutin (quercetin 3-O-glycoside), as the only source of carbon via an extracellular enzyme system. In this continuing study, a proteomic analysis was used to identify secreted proteins from A. flavus when grown on rutin. The growth media glucose and potato dextrose were used to identify differentially expressed secreted proteins. The secreted proteins were analyzed by 1- and 2-DE and MS/MS. A total of 51 unique A. flavus secreted proteins were identified from the three growth conditions. Ten proteins were unique to rutin-, five to glucose- and one to potato dextrose-grown A. flavus. Sixteen secreted proteins were common to all three media. Fourteen identifications were of hypothetical proteins or proteins of unknown functions. To our knowledge, this is the first extensive proteomic study conducted to identify the secreted proteins from a filamentous fungus.
Nitrendipine Protects Against Aminoglycoside Nephrotoxicity in the Rat (1987)

Aminoglycoside nephrotoxicity is a common clinical problem among hospitalized patients despite close attention to pharmacokinetics and dosing schedules. The present study was designed to evaluate the potential protective effect of nitrendipine, a calcium channel blocker, on the natural history of gentamicin renal injury in the rat. Gentamicin was administered intramuscularly in a dose of 40 mg/kg/day for 12 days to adult Fischer rats. Nitrendipine was given by gavage on a b.i.d. schedule in a dose of 30 mg/kg/day or 10 mg/kg/day. Gentamicin alone caused a significant decrease in glomerular filtration rate (GFR) and renal plasma flow (RPF). Concurrent administration of nitrendipine did not influence RPF, but promoted a significant increase in GFR. Nitrendipine also prevented the increase in urinary excretion of N-acetyl-glucosaminidase and beta-glucosidase, enzymatic markers of renal tubular injury in the gentamicin-treated animals. Gentamicin-induced pathologic injury was significantly ameliorated by nitrendipine. Renal cortical gentamicin content was diminished, but not significantly, by nitrendipine. The exact mechanism of action of nitrendipine in aminoglycoside-induced renal injury remains unknown. These observations suggest a potential pharmacologic approach to preventing a common problem with substantial morbidity.
62 questions about stilbestrol answered (1963)

The first stilbestrol feeding experiment with beef cattle was conducted 10 years ago (1953) at Iowa State University. Since then nearly every state university, many foreign countries and several feed manufacturers have conducted stilbestrol research. In these studies essentially all cattle feeding conditions have been explored. Information from more than 100 cattle experiments is used in this review to answer many of the questions posed at different times by different individuals regarding stilbestrol feeding.\nSome questions were answered in 1954 in Iowa State Pamphlet 215, "Questions and Answers About Adding Stilbestrol to Feeds for Growing and Fattening Beef Cattle." Since then stilbestrol usage has spread throughout the cattle feeding industry. This use of stilbestrol feeds has continued. More questions are being asked. The more recent questions reflect the impact of stilbestrol use upon all segments of the beef industry.\nStilbestrol is incorporated into cattle feeds for purposes of increasing liveweight gains and lowering the feed cost of gains. The incorporation process consists of mixing specially compounded stilbestrol premixes into cattle supplemental feeds. Feed manufacturers produce these supplemental feeds in accordance with state and federal regulations. Each bag or batch of supplemental feed carries a label stating the amount of stilbestrol in the supplement and directions for use.
Determination of catecholamines and their 3‐<i>O</i>‐methyl metabolites in mouse plasma (2001)

The determination of catecholamines and their 3-O-methyl metabolites in a single mouse plasma is necessary to understand the role of the sympathetic nervous activity, while the inactivation of catecholamines by catechol-O-methyltransferase indicates the activity of blood pressure regulation in animals. Here we report the basal catecholamines and their 3-O-methyl metabolite concentrations obtained from 15 microL of mouse plasma utilizing semi-microcolumn high-performance liquid chromatography (HPLC)-peroxyoxalate chemiluminescence detection system. The concentrations were 6.63 +/- 1.37 pmol/mL plasma, 0.49 +/- 0.10 pmol/mL plasma, 5.25 +/- 2.30 pmol/mL plasma, 3.23 +/- 0.84 pmol/mL plasma, 0.44 +/- 0.11 pmol/mL plasma, and 3.39 +/- 1.67 pmol/mL plasma for norepinephrine, epinephrine, dopamine, normetanephrine, metanephrine and 3-methoxytyramine, respectively (n = 5-7). Further, when blood pressure was reduced by minoxidil, plasma catecholamines were found to be significantly increased by the baroreflex-mediated response in mouse.
Concept mapping vs. web page hyperlinks as an information retrieval interface: preferences of postgraduate culturally diverse learners (2003)

The principal objective of this research project was to determine if and to what extent cultural factors prescribe interface choices by learners. Concept mapping and standard hyperlinks were offered as choices for information retrieval interfaces. The methods employed were to identify a set of culturally divisive factors, and then to test two different interfaces with a group of culturally diverse, advanced learners. Some of the results had to be ignored due to small sample sizes. The remaining results indicated that most choices, almost irrespective of culture divisive factors, were made in favour of the concept mapping interface. This finding confirmed that of another author in the field. The primary conclusion reached is that concept mapping should be considered as the interface of choice to a knowledge repository to be used by Master's students in Information management.
First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055 (2006)

The lack of endometrial proliferation and improvement of climacteric complaints as well as only few gynecologic organ-related adverse events are reported for the first time after a treatment period of 1 year. Due to the improved benefit:risk ratio, it must be assumed that the Cimicifuga racemosa special extract BNO 1055 is a safe alternative for treatment of climacteric complaints.
Detecting interspecific recombination with a pruned probabilistic divergence measure (2004)

Software, data and further supplementary material are available at the following website: http://www.bioss.sari.ac.uk/~dirk/Supplements/
Synthesis of Homogeneous Pt-Bimetallic Nanoparticles as Highly Efficient Electrocatalysts (2011)

Alloying has shown enormous potential for tailoring the atomic and electronic structures, and improving the performance of catalytic materials. Systematic studies of alloy catalysts are, however, often compromised by inhomogeneous distribution of alloying components. Here we introduce a general approach for the synthesis of monodispersed and highly homogeneous Pt-bimetallic alloy nanocatalysts. Pt3M (where M = Fe, Ni, or Co) nanoparticles were prepared by an organic solvothermal method and then supported on high surface area carbon. These catalysts attained a homogeneous distribution of elements, as demonstrated by atomic-scale elemental analysis using scanning transmission electron microscopy. They also exhibited high catalytic activities for the oxygen reduction reaction (ORR), with improvement factors of 2–3 versus conventional Pt/carbon catalysts. The measured ORR catalytic activities for Pt3M nanocatalysts validated the volcano curve established on extended surfaces, with Pt3Co being the most active alloy.