gebhart/patrepeval huggingface dataset:
Insulin Receptor Substrate-2 Binds to the Insulin Receptor through Its Phosphotyrosine-binding Domain and through a Newly Identified Domain Comprising Amino Acids 591–786 (1996)

We compared the interaction between the insulin receptor (IR) and the IR substrate (IRS) proteins IRS-1 and IRS-2) using the yeast two-hybrid system. Both IRS proteins interact specifically with the cytoplasmic portion of the IR and the related insulin-like growth factor-I receptor, and these interactions require receptor tyrosine kinase activity. Alignment of IRS-1 and IRS-2 revealed two conserved domains at the NH2 terminus, called IH1PH and IH2PTB, which resemble a pleckstrin homology (PH) domain and a phosphotyrosine binding (PTB) domain, respectively. The IH2PTB binds to the phosphorylated NPXY motif (Tyr-960) in the activated insulin receptor, providing a specific mechanism for the interaction between the receptor and IRS-1. Although the IH2PTB of IRS-2 also interacts with the NPEY motif of the insulin receptor, it is not essential for the interaction between the insulin receptor and IRS-2 in the yeast two-hybrid system. IRS-2 contains another interaction domain between residues 591 and 786, which is absent in IRS-1. This IRS-2-specific domain is independent of the IH2PTB and does not require the NPEY motif; however, it requires a functional insulin receptor kinase and the presence of three tyrosine phosphorylation sites in the regulatory loop (Tyr-1146, Tyr-1150, and Tyr-1151). Importantly, this novel domain mediates the association between IRS-2 and insulin receptor lacking the NPXY motif and may provide a mechanism by which the stoichiometry of regulatory loop autophosphorylation enhances IRS-2 phosphorylation.
Evaluation of plasma sprayed YSZ thermal barrier coatings with the CMAS deposits infiltration using impedance spectroscopy (2012)

The yttria-stabilized zirconia (YSZ) thermal barrier coatings (TBCs) prepared by atmospheric plasma spraying with different heat treatment period at the temperature of 1250 °C were studied in the present investigation. Electrochemical impedance spectroscopy (EIS) was employed to non-destructively examine the impedance and capacitance behavior of free standing YSZ coatings deposited by plasma spray with CMAS (calcium–magnesium–alumino-silicate) infiltration. Equivalent circuit was established on the basis of the biomodal structure in coatings. The sintering behavior of the coatings can be reflected by the changes of resistance and capacitance of the coating. By EIS, the microstructure evolution of the coating with CMAS deposits was discussed in detail.
Coupled photonic crystal nanobeam cavities (2009)

We describe the design, fabrication, and spectroscopy of coupled, high quality (Q) factor silicon nanobeam photonic crystal cavities. We show that the single nanobeam cavity modes are coupled into even and odd superposition modes, and we simulate the frequency and Q factor as a function of nanobeam spacing, demonstrating that a differential wavelength shift of 70 nm between the two modes is possible while maintaining Q factors greater than 106. For both on substrate and freestanding nanobeams, we experimentally monitor the response of the even mode as the gap is varied, and measure Q factors as high as 2×105.
Resolution limits to object tracking with subpixel accuracy (2012)

Subpixel methods increase the accuracy and efficiency of image detectors, processing units, and algorithms and provide very cost-effective systems for object tracking. Published methods achieve resolution increases up to three orders of magnitude. In this Letter, we demonstrate that this limit can be theoretically improved by several orders of magnitude, permitting micropixel and submicropixel accuracies. The necessary condition for movement detection is that one single pixel changes its status. We show that an appropriate target design increases the probability of a pixel change for arbitrarily small shifts, thus increasing the detection accuracy of a tracking system. The proposal does not impose severe restriction on the target nor on the sensor, thus allowing easy experimental implementation.
Fast Audio Fingerprinting System Using GPU and a Clustering-Based Technique (2016)

In this paper, we present our audio fingerprinting system that detects a transformed copy of an audio from a large collection of audios in a database. The audio fingerprints in this system encode the positions of salient regions of binary images derived from a spectrogram matrix. The similarity between two fingerprints is defined as the intersection of their elements (i.e. positions of the salient regions). The search algorithm labels each reference fingerprint in the database with the closest query frame and then counts the number of matching frames when the query is overlaid over the reference. The best match is based on this count. The salient regions fingerprints together with this nearest-neighbor search give excellent copy detection results. However, for a large database, this search is time consuming. To reduce the search time, we accelerate this similarity search by using a graphics processing unit (GPU). To speed this search even further, we use a two-step search based on a clustering technique and a lookup table that reduces the number of comparisons between the query and the reference fingerprints. We also explore the tradeoff between the speed of search and the copy detection performance. The resulting system achieves excellent results on TRECVID 2009 and 2010 datasets and outperforms several state-of-the-art audio copy detection systems in detection performance, localization accuracy and run time. For a fast detection scenario with detection speed comparable to the Ellis' Shazam-based system, our system achieved the same min NDCR as the NN-based system, and significantly better detection accuracy than Ellis' Shazam-based system.
SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF NEOVASCULAR MACULAR TELANGIECTASIA TYPE 2 (2015)

To image subretinal neovascularization in proliferative macular telangiectasia Type 2 (MacTel2) using swept source optical coherence tomography based microangiography (OMAG).Patients with macular telangiectasia Type 2 were enrolled in a prospective, observational study known as the MacTel Project and evaluated using a high-speed 1,050 nm swept-source OCT prototype system. The OMAG algorithm generated en face flow images from three retinal layers, and the region bounded by the outer retina and Bruch membrane, the choriocapillaris, and the remaining choroidal vasculature. The en face OMAG images were compared with images from fluorescein angiography and indocyanine green angiography.Three eyes with neovascular macular telangiectasia Type 2 were imaged. The neovascularization was best identified from the en face OMAG images that included a layer between the outer retinal boundary and Bruch membrane. Optical coherence tomography based microangiography images identified these abnormal vessels better than fluorescein angiography and were comparable to the images obtained using indocyanine green angiography. In all 3 cases, OMAG identified choroidal vessels communicating with the neovascularization, and these choroidal vessels were evident in the 2 cases with indocyanine green angiography imaging. In 1 case, monthly injections of bevacizumab reduced the microvascular complexity of the neovascularization, and the telangiectatic changes within the retinal microvasculature. In another case, less frequent bevacizumab therapy was associated with growth of the subretinal neovascular complex.Optical coherence tomography based microangiography imaging provided detailed, depth-resolved information about subretinal neovascularization in macular telangiectasia Type 2 eyes demonstrating superiority to fluorescein angiography imaging, and similarities to indocyanine green angiography imaging for documenting the retinal microvascular changes, the size and extent of the neovascular complex, the communications between the neovascular complex and the choroidal circulation, and the response to monthly bevacizumab therapy.
Development of high-efficiency solar cells on thin silicon through design optimization and defect passivation (2009)

The overall goal of this research is to improve fundamental understanding of the hydrogen passivation of defects in low-cost silicon and the fabrication of high-efficiency solar cells on thin crystalline silicon through low-cost technology development. A novel method was developed to estimate the flux of hydrogen, released from amorphous silicon nitride film, into the silicon. Rapid-firing-induced higher flux of hydrogen was found to be important for higher defect passivation. This was followed by the fabrication of solar cell efficiencies of ~ 17% on low-cost, planar cast multicrystalline silicon. Solar cell efficiencies and lifetime enhancement in the top, middle, and bottom regions of cast multicrystalline silicon ingots were explained on the basis of impurities and defects generally found in those regions. In an attempt to further reduce the cost, high-efficiency solar cells were fabricated on thin crystalline silicon wafers with full area aluminum-back surface field. In spite of loss in efficiency, wafer thinning reduced the module cost. Device modeling was performed to establish a roadmap towards high-efficiency thin cells and back surface recombination velocity and back surface reflectance were identified as critical parameters for high-efficiency thin cells. Screen-printed solar cells on float zone material, with efficiencies > 19% on 300 μm and > 18% on 140 μm were fabricated using a novel low-cost fabrication sequence that involved dielectric rear passivation along with local contacts and back surface field.
Seismic monitoring feasibility on Bu-Hasa field (2007)

Abstract Summary A 4D seismic feasibility study has been performed on carbonate reservoirs of the Bu Hasa field onshore Abu Dhabi. It concludes to the feasibility of the method as a reservoir injection monitoring tool, an interesting result when several recent papers [1] have suggested that 4D seismic may not be applicable to Middle East carbonate reservoirs due to their rock physics characteristics. 2D full wave equation and 3D convolutional modelling approaches have been combined in this study in order to maximize the reliability of the predictions while optimizing the cost effectiveness of the study. Because the assessment of repeatability noise indicated a realistically irreducible threshold for high resolution 4D surface seismic and a possible limitation for WAG monitoring, a 4D well seismic exercise was simulated which overcame those limitations. Introduction The Bu Hasa Field, onshore Abu Dhabi, is a super giant carbonate oil field. The Lower Cretaceous Shu'aiba member of the Thamama formation is the main reservoir with porosity above 30%. This field has been producing since 1963 and production mechanism is involving peripheral water injection and crestal gas and water injection. (Figure 1) The "monitoring" of this field is essential to optimize the production parameters and the value of using seismic information (4D) as an additional reservoir monitoring tool has been assessed [2]. Although seismic is not always considered as fit for purpose for limestone reservoir monitoring because of the stiffness of the rocks, Bu Hasa field is a favourable case because of the high porosities encountered. (up to 30%) Bu-Hasa oil is light and very compressive; therefore, the mechanical behaviour of the oil is closer to gas than water. This means injected water front movements should be more easily detected than injected gas front (in the oil).
Versatile Synthesis and Fungicidal Activities of 6‐Amino‐3‐Alkylthio‐1,5‐dihydro‐1‐phenyl‐pyrazolo[3,4‐d]pyrimidin‐4‐one Derivatives. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Treatment of experimental osteomyelitis with antibiotic‐impregnated bone graft substitute (1993)

The model of Norden was used to induce osteomyelitis in the left tibia of New Zealand White rabbits. Twenty-one days following inoculation, the animals had primary debridement and then were randomized into one of three treatment groups. Group I received no additional treatment; in Group II, plain hydroxyapatite beads were packed into the defect; and in Group III, gentamicin crobefat-loaded hydroxyapatite beads were packed into the defect. The animals were observed for 40 days after the primary debridement and then were killed. The intensity of infection was determined by swab cultures and quantitative bacterial cultures of the debrided material. At primary debridement, all of the animals in each group were equally infected. At the time of secondary debridement, only the animals in Group III had a statistically significant reduction in infection (p < 0.001). In this study, we demonstrated that an antibiotic-loaded osteoinductive ceramic bead can effectively eliminate bacteria from an osteomyelitic cavity.
Small-Resistance and High-Quality-Factor Magnetic Integrated Inductors on PCB (2009)

We have designed and fabricated both single-coil and parallel-coil magnetic integrated inductors with extremely small resistances and high quality factors on an 8-in-round printed circuit board (PCB) substrate for microprocessor power delivery applications. The dc resistances of these inductors are less than 12 mOmega. Soft magnetic material CoFeHfO was successfully integrated into the inductor fabrication to increase the inductance. The quality factors are more than 80 in a frequency range of 1.5-2 GHz for air-core inductors and more than 23 in a range of 200-300 MHz for magnetic inductors. The net inductance improvement of the magnetic inductor over air-core inductor is about 12%, which could be further enhanced with a thicker magnetic core, according to our theoretic calculation and HFSS simulation. We also characterized the permeability spectra of CoFeHfO material on the PCB substrate, simulated the high-frequency performance of the magnetic integrated inductor by HFSS, and, for the first time, reached a good agreement with the experimental data. The experimental and simulation results of the magnetic inductors as compared to those of the air-core inductors point out the future direction to further optimize magnetic integrated inductors.
Digital Radio Mondiale: key technical features (2002)

Digital Radio Mondiale (DRM) is a system that promises to reinvigorate the use of the broadcasting bands below 30 MHz. It offers a dramatic improvement in audio quality, not only improving the audio bandwidth and signal-to-noise ratio, but also countering the effects of selective fading and audible interference from other stations. It is also designed to support various features that will make receiver operation more user-friendly. This article describes the basic 'mechanics' of DRM and its features, which include station identification, alternative frequency lists and support for time-varying frequency schedules-of particular importance in HF broadcasting.
Spectral Analysis of the High Resolution QRS Complex During Exercise‐Induced Ischemia (1996)

Background: The effect of acute myocardial infarction and regional ischemia on the frequency content of the ECG signal has been described by several investigators. In the present study, the feasibility of assessing changes in the QRS spectrum during exercise testing, and whether these changes are related to the occurrence of ischemia were examined. Methods: Spectral analysis of the high resolution ECGs from leads V 3 , V 4 , V 5 , and V 6 were performed in two groups of male subjects before, during, and following treadmill exercise testing. Group A included 32 coronary artery disease (CAD) patients, with arteriographically proven >75% obstruction of at least two main coronary arteries, and group B included 30 healthy subjects, without history or symptoms of CAD. Signal averaging and filtering techniques were used in order to enhance the signal‐to‐noise ratio of the recorded ECGs. The power spectrum of the averaged QRS waveform for the different stages of the exercise testing was computed using a Fast Fourier Transform, and the slope of the linear regression line was found in the frequency range 7.81–249.92 Hz on the plot of log((amplitude) 2 ) versus log(frequency). Results: Regression line slopes immediately after peak exercise were significantly lower for the CAD group than for the healthy subjects in 3 of the 4 examined leads. No significant changes in slopes were found between the two groups at rest or during late recovery. Comparing the differences between slopes at different stages of the test revealed that the difference between postexercise slope and rest slope has lower mean values for the CAD group in all four leads, with a significant difference in lead V6, and for the difference between postexercise slope and recovery slope, lower mean values were found for the CAD group in all four leads, with a significant difference in V5 and V6. Conclusions: These findings indicate that ischemic changes affect the power spectrum of the QRS complex, and result in a steeper regression line on a log‐log scale.
Molecular Tools to Study<i>Physcomitrella patens</i> (2005)

The moss Physcomitrella patens has become a suitable model plant system for the analysis of diverse aspects of modern plant biology. The research strategies have been influenced by the implementation of state-of-the-art cell culture and molecular biology techniques. The forthcoming completion of the Physcomitrella genome sequencing project will generate many open questions, the examination of which will rely on a diverse set of molecular tools. Within this article, we intend to introduce the essential cell culture and molecular biology techniques which have been adopted in recent years to make Physcomitrella amenable to a wide range of genetic analyses. Many research groups have made valuable contributions to improve the methodology for the study of Physcomitrella. We would like to apologise to all colleagues whose important contributions could not be cited within this manuscript.
Characterization of surface mobility in MOS structures containing interfacial cesium ions (1989)

The degradation of inversion-layer electron and hole mobility in silicon MOS devices by interface charge at 295 and 77 K is discussed. The charge was controllably introduced using cesium implanted into the gate oxide and subsequently diffused to the oxide-substrate interface. The charged-impurity-scattering component of the mobility has been extracted and characterized as a function of inversion charge density and cesium dose.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Osmotic pressure regulates abg-rENaC expressed in Xenopus oocytes (1998)

Ji, Hong-Long, Catherine M. Fuller, and Dale J. Benos. Osmotic pressure regulates abg-rENaC expressed in Xenopus oocytes. Am. J. Physiol. 275 (Cell Physiol. 44): C1182–C1190, 1998.—The hypothesis that amiloride-sensitive Na1 channels (ENaC) are involved in cell volume regulation was tested. Anisosmotic ND-20 media (ranging from 70 to 450 mosM) were used to superfuse Xenopus oocytes expressing abg-rat ENaC (abg-rENaC). Whole cell currents were reversibly dependent on external osmolarity. Under conditions of swelling (70 mosM) or shrinkage (450 mosM), current amplitude decreased and increased, respectively. In contrast, there was no change in current amplitude of H2O-injected oocytes to the above osmotic insults. Currents recorded from abg-rENaC-injected oocytes were not sensitive to external Cl2 concentration or to the K1 channel inhibitor BaCl2. They were sensitive to amiloride. The concentration of amiloride necessary to inhibit one-half of the maximal rENaC current expressed in oocytes (Ki; apparent dissociation constant) decreased in swollen cells and increased in shrunken oocytes. The osmotic pressure-induced Na1 currents showed properties similar to those of stretch-activated channels, including inhibition by Gd31 and La31, and decreased selectivity for Na1. abg-rENaC-expressing oocytes maintained a nearly constant cell volume in hypertonic ND-20. The present study is the first demonstration that abg-rENaC heterologously expressed in Xenopus oocytes may contribute to oocyte volume regulation following shrinkage.
Submersible Outboard Electric Motor/Propulsor (1989)

Mr. Taylor has more than 18 years of experience in the field of research and development engineering. Since joining Westinghouse in 1974 he has been involved in the design and development of advanced electrical machinery including large, high power density motors for electric drive ship propulsion, pulsed homopolar generators for electromagnetic launchers, high current density contacts for switching applications, research in automated manufacturing, and robotic system development. He is currently managing a section that deals with rotating power equipment for military applications, with emphasis on thermal and electromagnetic modeling. ABSTRACT A demonstration submersible outboard electric motor/ propulsor has been designed, built, and successfully tested. This concept involves mounting a propeller directly inside a rotor of a specially designed induction motor. This motor/ propulsor has the advantages of direct seawater cooling and bearing lubrication, direct drive, shrouded propeller, variable positioning, easy access, and high maneuverability. The motor/propulsor is readily adaptable to dual, independently‐controlled and contra‐rotating propellers without the need for gears. The concept has been investigated conceptually for application to primary propulsion, secondary propulsion, and pod drives, for amphibious, surface, and undersea vehicles.
Bone Marrow Transplantation Temporarily Improves Pancreatic Function in Streptozotocin-Induced Diabetes: Potential Involvement of Very Small Embryonic-Like Cells (2010)

These data suggest that VSEL cells are mobilized into injured pancreatic tissue and contribute to beta-cell regeneration. Transplantation of BM-derived cells improves the function of injured pancreas, although the response is not sufficient to restore sustained normoglycemia.
Prediction of drug response using genomic signatures from the Cancer Cell Line Encyclopedia (2010)

Abstract Accurate prediction of patient drug response is required for successful personalized medicine. Cancer is a disease resulting from myriad genetic alterations. Accordingly, it should be possible to predict drug response of specific cancers using genetic and molecular signatures. To aid this effort, an ongoing collaboration established between Novartis and the Broad Institute called the Cancer Cell Line Encyclopedia (CCLE) has (i) comprehensively characterized genome-scale mRNA expression, copy number alteration and mutation profiles for nearly 1000 cancer cell line models spanning many tumor types and (ii) profiled ~500 of these cell lines against ~1000 anticancer compounds. Using these data, we are developing a scalable, extensible predictive modeling framework based on various supervised learning methods that include both categorical classification and linear regression approaches to predict compound sensitivity. By cross-validation of the generated models against test data sets, we quantitatively estimated model performance. Our initial results validate several preexisting genetic predictors of sensitivity. In addition, our models reported 70% or higher sensitivity and specificity for a number of compounds and yielded interesting potentially novel predictive features that, in some cases, outperform previously existing genetic predictors of sensitivity. Our integrative approach demonstrates that pharmacological profiling of large, genomically annotated cancer model systems, coupled with systematic predictive modeling, can uncover novel predictors of drug response and may ultimately aid patient stratification. This talk is also presented as Poster A4.