gebhart/patrepeval huggingface dataset:
Increased expression of a set of genes enriched in oxygen binding function discloses a predisposition of breast cancer bone metastases to generate metastasis spread in multiple organs (2012)

Bone is the preferential site of distant metastasis in breast carcinoma (BrCa). Patients with metastasis restricted to bone (BO) usually show a longer overall survival compared to patients who rapidly develop multiple metastases also involving liver and lung. Hence, molecular predisposition to generate bone and visceral metastases (BV) represents a clear indication of poor clinical outcome. We performed microarray analysis with two different chip platforms, Affymetrix and Agilent, on bone metastasis samples from BO and BV patients. The unsupervised hierarchical clustering of the resulting transcriptomes correlated with the clinical progression, segregating the BO from the BV profiles. Matching the twofold significantly regulated genes from Affymetrix and Agilent chips resulted in a 15-gene signature with 13 upregulated and two downregulated genes in BV versus BO bone metastasis samples. In order to validate the resulting signature, we isolated different MDA-MB-231 clonal subpopulations that metastasize only in the bone (MDA-BO) or in bone and visceral tissues (MDA-BV). Six of the signature genes were also significantly upregulated in MDA-BV compared to MDA-BO clones. A group of upregulated genes, including Hemoglobin B (HBB), were involved in oxygen metabolism, and in vitro functional analysis of HBB revealed that its expression in the MDA subpopulations was associated with a reduced production of hydrogen peroxide. Expression of HBB was detected in primary BrCa tissue but not in normal breast epithelial cells. Metastatic lymph nodes were frequently more positive for HBB compared to the corresponding primary tumors, whereas BO metastases had a lower expression than BV metastases, suggesting a positive correlation between HBB and ability of bone metastasis to rapidly spread to other organs. We propose that HBB, along with other genes involved in oxygen metabolism, confers a more aggressive metastatic phenotype in BrCa cells disseminated to bone.
Biocatalytic Esterification in Supercritical Carbon Dioxide by Using a Lipid-coated Lipase (1998)

Abstract A lipid-coated lipase is soluble and acts as a more efficient catalyst for triglyceride syntheses in supercritical carbon dioxide (scCO2) than in conventional organic solvents, and the reactivity can be controlled reversibly by changing pressure and temperature in scCO2.
Acetylated saponins with molluscicidal activity from <i>Sapindus rarak</i> : Unambiguous structure determination by proton nuclear magnetic resonance and quantitative analysis (1992)

Abstract Four monodesmosidic triglycosides, bearing up to two acetyl moieties on the terminal sugar, have been isolated from the pericarp of fruits of Sapindus rarak DC (Sapindaceae). The positions of the acetyl groups and interglycosidic linkages have been established by proton nuclear magnetic resonance spectroscopy, including double‐quantum filtered phase‐sensitive COSY and homonuclear Overhauser enhancement difference measurements. A method for the qualitative analysis of saponins by reversed phase high pressure liquid chromatography (HPLC) has been developed. The total saponin content was determined by HPLC analysis of hederagenin liberated by acidic hydrolysis of the methanolic extract. The molluscicidal activity (LC 100/24h ) of the saponins ranges from 6.25 to 12.5 ppm.
Fertilization of zona‐drilled mouse oocytes treated with a monoclonal antibody to the zona glycoprotein, ZP3 (1988)

Opening a small aperture in the zona pellucida of mouse oocytes by using micromanipulation and a stream of acidified Tyrode's solution (zona drilling) improved the efficiency of in vitro fertilization at low sperm concentrations without adversely affecting development to the blastocyst stage. Zona drilling also permitted in vitro fertilization and development when sperm penetration through the zona was blocked by a monoclonal antibody to the protein core of the zona glycoprotein, ZP3. These results provide a direct demonstration that sperm entry occurs through the aperture and also suggest that zona drilling of human oocytes may offer a therapeutic approach when autoantibodies to the zona pellucida are suspected as a cause of infertility.
Control strategy and site selection of a shunt active filter for damping of harmonic propagation in power distribution systems (1997)

This paper deals with a shunt active filter which will be installed by an electric utility, putting much emphasis on the control strategy and the best point of installation of the shunt active filter on a feeder in a power distribution system. The objective of the shunt active filter is to damp harmonic propagation, which results from harmonic resonance between many capacitors for power factor improvement and line inductors in the feeder, rather than to minimize voltage distortion throughout the feeder. Harmonic mitigation is a welcome "by-product" of the shunt active filter, which comes from damping of harmonic propagation. This paper concludes that the shunt active filter based on detection of voltage at the point of installation is superior in stability to others, and that the best site selection is not the beginning terminal but the end terminal of the primary line in the feeder. Computer simulation is performed to verify the validity and effectiveness of the shunt active filter by means of an analog circuit simulator, which is characterized by installing it on a feeder of a radial distribution system in a residential area.
Effectiveness of the single‐shot dual‐energy subtraction technique for portal images (2011)

The aim of the present study was to evaluate the clinical efficacy of the single-shot dual-energy subtraction technique for obtaining portal images. We prepared two storage phosphor plates for this study. A 1 mm thick tungsten sheet was placed between the two storage phosphor plates. A single use of the double-exposure technique provides two portal images simultaneously (i.e., a standard image and a low-contrast image), using the same patient position and with no additional radiation delivered to the patient. A bone-enhanced image is created by image subtraction between these two images. For evaluation of clinical efficacy, three treatment sites--the brain, lung, and pelvis--were imaged. Ten sets of images were obtained for each site, and five landmarks were selected for each treatment site. The visibility of each landmark and the ease of overall verification for the selected treatment sites were assessed separately for the standard and bone-enhanced images. Four observers consisting of one radiation oncologist and three radiation therapists participated in the present study. For most of the landmarks studied, the bone-enhanced images were significantly superior to the standard images. Regarding the ease of overall verification, the bone-enhanced images were significantly superior to the standard images at all sites. The p-values of mean rating for the brain, lung, and pelvis were 0.002, 0.012, and 0.003, respectively. The bone-enhanced images obtained using our technique increased the image quality in terms of bone visibility, and are considered useful for routine clinical practice.
Measurement of Complex Ion Stability by the Use of Ion Exchange Resins (1956)

This chapter contains sections titled: Introduction Theoretical Basis of Ion Exchange Method Experimental Concluding Comments
Can Markets Learn to Avoid Bubbles? (2002)

One of the most striking results in experimental economics is the ease with which market bubbles form in a laboratory setting and the difficulty of preventing them. This article re-examines bubble experiments in light of the results of an earlier series of market experiments that show how learning occurs in markets characterized by an asymmetry of information between buyers and sellers, such as found in Akerlof's lemons model and Spence's signaling model. Markets with asymmetric information are incomplete because they lack markets for specific levels of product quality. Such markets either lump all qualities together (lemons) or using external indications of quality to separate them (signaling). Similarly, the markets used in bubble experiments are incomplete in that they are lacking a complete set of forward or futures markets, depriving traders of the information supplied by the prices in those markets. Preliminary experimental results suggest that the addition of a single forward market can sometimes mitigate bubble formation and this article suggests more extensive research in this direction is warranted. Market bubbles outside of the laboratory usually are found in markets in which forward and futures markets are either legally restricted or otherwise limited. Experimentation in markets with asymmetric information also indicates that the ability of subjects to learn how to send and receive signals can be enhanced by changing the way that market information is presented to them. We explore how this result might be used to help asset markets learn to avoid bubbles
Atrial Contractile Dysfunction After Short-term Atrial Fibrillation Is Reduced by Verapamil but Increased by BAY K8644 (1996)

Atrial contractile dysfunction after short-term atrial fibrillation is reduced by the calcium antagonist verapamil, which suggests that transsarcolemmal calcium influx contributed to this dysfunction. The calcium agonist BAY K8644 increased postfibrillation atrial contractile dysfunction. Atrial ischemia was not observed during fibrillation.
Inside Moire patterns (1997)

Moire patterns are produced by the interaction of two overlaid patterns. With a little geometry, it is easy to understand where they come from and how to create and control them. To demonstrate Moire effects the author uses a very simple set of patterns: sheets of parallel lines, called gratings.
Amyloid beta peptide 1–40 enhances the action of Toll‐like receptor‐2 and ‐4 agonists but antagonizes Toll‐like receptor‐9‐induced inflammation in primary mouse microglial cell cultures (2005)

The interaction of endogenous and exogenous stimulators of innate immunity was examined in primary cultures of mouse microglial cells and macrophages after application of defined Toll-like receptor (TLR) agonists [lipopolysaccharide (LPS) (TLR4), the synthetic lipopeptide Pam3Cys-Ser-Lys4 (Pam3Cys) (TLR2) and single-stranded unmethylated CpG-DNA (CpG) (TLR9)] alone and in combination with amyloid beta peptide (Abeta) 1-40. Abeta1-40 stimulated microglial cells and macrophages primed by interferon-gamma in a dose-dependent manner. Co-administration of Abeta1-40 with LPS or Pam3Cys led to an additive release of nitric oxide (NO) and tumour necrosis factor alpha (TNF-alpha). This may be one reason for the clinical deterioration frequently observed in patients with Alzheimer's disease during infections. In contrast, co-application of Abeta1-40 with CpG led to a substantial decrease of NO and TNF-alpha release compared with stimulation with CpG alone. Abeta1-40 and CpG did not co-localize within the same subcellular compartment, making a direct physicochemical interaction as the cause of the observed antagonism very unlikely. This suggests that not all TLR agonists enhance the stimulatory effect of A beta on innate immunity.
Augmented reality based on driving situation awareness in vehicle (2015)

In this paper, we introduce a vehicle augmented reality (AR) system to present information of driving situation awareness in a vehicle. Today, manufacturers related with vehicles have been pointing to AR as a next-generation visualization technology for in-car driving displays. Such in-vehicle AR-based display systems are helpful in reducing driver distractions, thereby increasing driver safety, and provide intelligent interactions for enhancing driver convenience. The proposed system offers information of driving situation and warning to a driver through the augmented reality using head-up display. The system consists of several sub-modules such as sensor, vehicle/pedestrian recognition, vehicle state information, driving information, time to collision (TTC), threat assessment, warning strategy, and display modules. We have defined the threat level and the presentation of AR information based on TTC values and driver's preference throughout experiments. The proposed system have been installed to a test vehicle with a vehicle AR information system prototype and carried out in the real road environments. The proposed system demonstrates to offer intuitively danger information according to the presentation rules to a driver on real road.
Photonic Interconnects for Interposer-based 2.5D/3D Integrated Systems on a Chip (2016)

Instead of a single die per chip (package) multiple dies stacked vertically (3D) and placed on an interposer (2.5D), is emerging as the building block for the future in both mobile and high-performance applications. We identify that bandwidth, energy per bit, and the ability to support a large amount of memory, are the key requirements of the inter-die Network on Chip (NoC). We propose to use an interposer with optical interconnections exploiting AWGR (Arrayed Waveguide Grating Router) wavelength routing to realize a 16x16 photonic NoC with a bisection bandwidth of 16 Tb/s. We propose a baseline network, which consumes 2.81 pJ/bit assuming 100% utilization. We show that the power is dominated by the electro-optical interface of the transmitter, which can be reduced by a more aggressive design that improves the energy per bit to 0.437 pJ/bit at 100% utilization. The networks exhibit very low latency as they are based on an optical crossbar topology and are scalable to multiple chips to support 1 TB of memory or more to meet the requirements of Exascale computing.
ChemInform Abstract: Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α‐Reductase. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supercritical Fluid Chromatography – Theoretical Background and Applications on Natural Products (2015)

The use of supercritical fluid chromatography for natural product analysis as well as underlying theoretical mechanisms and instrumental requirements are summarized in this review. A short introduction focusing on the historical development of this interesting separation technique is followed by remarks on the current instrumental design, also describing possible detection modes and useable stationary phases. The overview on relevant applications is grouped based on their basic intention, may it be (semi)preparative or purely analytical. They indicate that supercritical fluid chromatography is still primarily considered for the analysis of nonpolar analytes like carotenoids, fatty acids, or terpenes. The low polarity of supercritical carbon dioxide, which is used with modifiers almost exclusively as a mobile phase today, combined with high efficiency and fast separations might explain the popularity of supercritical fluid chromatography for the analysis of these compounds. Yet, it has been shown that more polar natural products (e.g., xanthones, flavonoids, alkaloids) are separable too, with the same (if not superior) selectivity and reproducibility than established approaches like HPLC or GC.
Image metrology and system controls for scanning beam interference lithography (2001)

We are developing scanning beam interference lithography (SBIL) for writing and reading large gratings with nanometer level distortion. Our distortion goals require fringe locking to a moving substrate with subnanometer spatial phase error while measuring and controlling the fringe period to approximately one part per million. In this article, we describe the SBIL optical system design along with some major subsystems. The design incorporates measurements and controls of the parameters that limit the accuracy of our system. We describe in detail a novel image metrology scheme, which uses interferometry to measure in situ both the period and the phase of the grating image formed by the interference of two laser beams. For a grating period of approximately 2 μm, experiments demonstrate a period measurement repeatability of three parts per ten thousand, one sigma. Phase measurement indicates a slow fringe drift at 0.25 mrad/s. Both the repeatability error and the phase drift are expected to improve by about three orders of magnitude after several improvements including the installation of an environmental enclosure and thermally stable metrology frames.
A Bottom-Following Preview Controller for Autonomous Underwater Vehicles (2006)

The paper addresses the problem of bottom-following for autonomous underwater vehicles by taking into account the terrain characteristics ahead of the vehicle, as measured by two echo sounders. The methodology used to solve this problem amounts to posing it as a discrete time path following control problem where a conveniently defined error state space model of the plant is augmented with bathymetric (i.e. depth) preview data. A piecewise affine parameter-dependent model representation is used to accurately describe the AUV linearized error dynamics for a pre-defined set of operating regions. For each region, the synthesis problem is stated as a state feedback H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> control problem for affine parameter-dependent systems and solved using Linear Matrix Inequalities (LMIs). The resulting nonlinear controller is implemented within the scope of gain-scheduled control theory using the D-methodology. Simulation results obtained with a full nonlinear model of the INFANTE AUV are presented and discussed
Telomerase in gynecologic cancers (1997)

Telomerase activity might be a valuable diagnostic and prognostic tool in gynecologic and other types of cancer, and telomerase inhibition might prove to be a significant therapeutic approach for some types of cancer. Better understanding of the relation between telomerase activation, tumor suppressor genes, and oncogenes might clarify several aspects of early tumorigenesis and result in development of novel approaches to early cancer detection and prevention.
Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor (2013)

The phosphate-dependent transition between enzymatically inert dimers into catalytically capable tetramers has long been the accepted mechanism for the glutaminase activation. Here, we demonstrate that activated glutaminase C (GAC) self-assembles into a helical, fiber-like double-stranded oligomer and propose a molecular model consisting of seven tetramer copies per turn per strand interacting via the N-terminal domains. The loop (321)LRFNKL(326) is projected as the major regulating element for self-assembly and enzyme activation. Furthermore, the previously identified in vivo lysine acetylation (Lys(311) in humans, Lys(316) in mouse) is here proposed as an important down-regulator of superoligomer assembly and protein activation. Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide, a known glutaminase inhibitor, completely disrupted the higher order oligomer, explaining its allosteric mechanism of inhibition via tetramer stabilization. A direct correlation between the tendency to self-assemble and the activity levels of the three mammalian glutaminase isozymes was established, with GAC being the most active enzyme while forming the longest structures. Lastly, the ectopic expression of a fiber-prone superactive GAC mutant in MDA-MB 231 cancer cells provided considerable proliferative advantages to transformed cells. These findings yield unique implications for the development of GAC-oriented therapeutics targeting tumor metabolism.
Real-Time Ultrasound Segmentation, Analysis and Visualisation of Deep Cervical Muscle Structure (2016)

Despite widespread availability of ultrasound and a need for personalised muscle diagnosis (neck/back pain-injury, work related disorder, myopathies, neuropathies), robust, online segmentation of muscles within complex groups remains unsolved by existing methods. For example, Cervical Dystonia (CD) is a prevalent neurological condition causing painful spasticity in one or multiple muscles in the cervical muscle system. Clinicians currently have no method for targeting/monitoring treatment of deep muscles. Automated methods of muscle segmentation would enable clinicians to study, target, and monitor the deep cervical muscles via ultrasound. We have developed a method for segmenting five bilateral cervical muscles and the spine via ultrasound alone, in real-time. Magnetic Resonance Imaging (MRI) and ultrasound data were collected from 22 participants (age: 29.0±6.6, male: 12). To acquire ultrasound muscle segment labels, a novel multimodal registration method was developed, involving MRI image annotation, and shape registration to MRI-matched ultrasound images, via approximation of the tissue deformation. We then applied polynomial regression to transform our annotations and textures into a mean space, before using shape statistics to generate a texture-to-shape dictionary. For segmentation, test images were compared to dictionary textures giving an initial segmentation, and then we used a customized Active Shape Model to refine the fit. Using ultrasound alone, on unseen participants, our technique currently segments a single image in [Formula: see text] to over 86% accuracy (Jaccard index). We propose this approach is applicable generally to segment, extrapolate and visualise deep muscle structure, and analyse statistical features online.
Single polymer dynamics under large amplitude oscillatory extension (2016)

The dynamics of single polymers in large-amplitude oscillatory extensional flow are studied over a wide range of flow strengths and cycle frequencies using a combination of single-molecule experiments and Brownian dynamics simulations.
Miniaturised coplanar waveguide-fed antenna and band-notched design for ultra-wideband applications (2009)

A miniaturised coplanar waveguide-fed ultra-wideband (UWB) antenna is presented here. The wideband operation is obtained through an optimised curvature of the radiating element. The input impedance of the antenna is matched using an elliptically tapered coplanar waveguide line. A high-band rejection characteristic at wireless local area network frequencies is achieved by inserting an ω-shaped slot on the antenna surface. The frequency domain dispersion characteristic is studied by means of the antenna transfer function both numerically and experimentally. Time domain characteristic of the antenna is investigated in detail for both UWB single-band and multiband schemes. In order to efficiently characterise the antenna system for an arbitrary pulse source excitation, the pole/residue model of the antenna system transfer function is presented using the matrix-pencil method.
[A rapid method for detecting seven kinds of American ginseng tea bags by FTIR spectroscopy]. (2002)

A rapid and non-destructive method, was used to identify seven commercial American Ginseng Tea bags by Fourier-transform infrared spectroscopy (FTIR) in this paper. It could be seen from the results, that each sample has its own characteristic infrared spectrum. Also, the seven tea bags could be divided into two groups: one is made from pure Ginseng powders, and the other is made by Ginseng extractives and additives. The information of additives used by factories could be identified by IR spectra. For example, some factories use glucose, and the others use sucrose as the additives. Furthermore, the quality of the tea bags was identified by the intensity ratio of Ginsengs and additives. In HPLC, the total saponin in tea bags made from Ginseng powders is 4 times higher than that made by Ginseng extractives. Therefore, HPLC analysis gave the same result with FTIR. It is proved that FTIR is a very fast, simple and reliable method to identify Chinese medicine.