gebhart/patrepeval huggingface dataset:
Machine Learning Prediction Models for Chronic Kidney Disease using National Health Insurance Claim Data in Taiwan (2020)

ABSTRACT Background and Objective Chronic kidney disease (CKD) represent a heavy burden on the healthcare system because of the increasing number of patients, high risk of progression to end-stage renal disease, and poor prognosis of morbidity and mortality. The aim of this study is to develop a machine-learning model that uses the comorbidity and medication data, obtained from Taiwan's National Health Insurance Research Database, to forecast whether an individual will develop CKD within the next 6 or 12 months, and thus forecast the prevalence in the population. Methods A total of 18,000 people with CKD and 72,000 people without CKD diagnosis along with the past two years of medication and comorbidity data matched by propensity score were used to build a predicting model. A series of approaches were tested, including Convoluted Neural Networks (CNN). 5-fold cross-validation was used to assess the performance metrics of the algorithms. Results Both for the 6 month and 12-month models, the CNN approach performed best, with the AUROC of 0.957 and 0.954, respectively. The most prominent features in the tree-based models were identified, including diabetes mellitus, age, gout, and medications such as sulfonamides, angiotensins which had an impact on the progression of CKD. Conclusions The model proposed in this study can be a useful tool for the policy-makers helping them in predicting the trends of CKD in the population in the next 6 to 12 months. Information provided by this model can allow closely monitoring the people with risk, early detection of CKD, better allocation of resources, and patient-centric management
Techniques of maintaining evolving component-based software (2000)

Component based software engineering has been increasingly adopted for software development. Such an approach using reusable components as the building blocks for constructing software, on one hand, embellishes the likelihood of improving software quality and productivity; on the other hand, it consequently involves frequent maintenance activities, such as upgrading third party components or adding new features. The cost of maintenance for conventional software can account for as much as two-thirds of the total cost, and it can likely be even more for maintaining component based software. Thus, an effective maintenance technique for component based software is strongly desired. The authors present a technique that can be applied on various maintenance activities over component based software systems. The technique proposed utilizes a static analysis to identify the interfaces, events and dependence relationships that would be affected by the modification in the maintenance activity. The results obtained from the static analysis along with the information of component interactions recorded during the execution of each test case are used to guide test selection in the maintenance phase. The empirical results show that with 19% effort our technique detected 71% of the faults in an industrial component based system, which demonstrates the great potential effectiveness of the technique.
Mechanistic Studies on the Autoxidation of α-Guaiene: Structural Diversity of the Sesquiterpenoid Downstream Products (2015)

Two unstable hydroperoxides, 6b and 10a, and 13 downstream sesquiterpenoids have been isolated from the autoxidation mixture of the bicyclic sesquiterpene α-guaiene (1) on cellulose filter paper. One of the significant natural products isolated was rotundone (2), which is the only known impact odorant displaying a peppery aroma. Other products included corymbolone (4a) and its C-6 epimer 4b, the (2R)- and (2S)-rotundols (7a/b), and several hitherto unknown epimers of natural chabrolidione A, namely, 7-epi-chabrolidione A (3a) and 1,7-epi-chabrolidione A (3b). Two 4-hydroxyrotundones (8a/b) and a range of epoxides (9a/b and 5a/b) were also formed in significant amounts after autoxidation. Their structures were elucidated on the basis of spectroscopic data and X-ray crystallography, and a number of them were confirmed through total synthesis. The mechanisms of formation of the majority of the products may be accounted for by initial formation of the 2- and 4-hydroperoxyguaienes (6a/b and 10a/b) followed by various fragmentation or degradation pathways. Given that α-guaiene (1) is well known to exist in the essential oils of numerous plants, coupled with the fact that aerial oxidation to form this myriad of downstream oxidation products occurs readily at ambient temperature, suggests that many of them have been overlooked during previous isolation studies from natural sources.
Fabrication of large area resin microlens arrays using gas-assisted ultraviolet embossing (2008)

Large-area microlens arrays are becoming important components in many applications such as LCD-TV diffusers. This paper reports a uniform pressure, low temperature process for their fabrication. The process integrates gas-assisted embossing and UV-curing embossing. During the process, the 230mm x 203mm PMMA substrate is pressed against the stainless-steel stamper coated with UV-curable resin. Under the gas pressuring and UV irradiating, a large array of microlens can be formed. By using this process, high embossing temperature and high embossing pressure can be avoided. Little residual stress is observed in the embossed PMMA substrate. The uniformity of large-area fabrication and optical properties of fabricated resin microlens array have been verified. This study has successfully shown the potential of this gas-assisted UV embossing process for the replication of large-area microstructures.
Mutation in the Magnesium Binding Site of hMSH6 Disables the hMutSα Sliding Clamp from Translocating along DNA (2000)

In human cells, binding of base/base mismatches and small insertion/deletion loops is mediated by hMutSalpha, a heterodimer of hMSH2 and hMSH6. In the presence of ATP and magnesium, hMutSalpha dissociates from the mismatch by following the DNA contour in the form of a sliding clamp. This process is enabled by a conformational change of the heterodimer, which is driven by the binding of ATP and magnesium in the Walker type A and B motifs of the polypeptides, respectively. We show that a purified recombinant hMutSalpha variant, hMutSalpha 6DV, which contains an aspartate to valine substitution in the Walker type B motif of the hMSH6 subunit, fails to undergo the conformational change compatible with translocation. Instead, its direct dissociation from the mismatch-containing DNA substrate in the presence of ATP and magnesium precludes the assembly of a functional mismatch repair complex. The "translocation-prone" conformation of wild type hMutSalpha could be observed solely under conditions that favor hydrolysis of the nucleotide and mismatch repair in vitro. Thus, whereas magnesium could be substituted with manganese, ATP could not be replaced with its slowly or nonhydrolyzable homologues ATP-gammaS or AMPPNP, respectively. The finding that ATP induces different conformational changes in hMutSalpha in the presence and in the absence of magnesium helps explain the functional differences between hMutSalpha variants incapable of binding ATP as compared with those unable to bind the metal ion.
Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab′) <sub>2</sub> (2010)

Autoimmune encephalomyelitis may be ameliorated experimentally by enhancing NK cell-mediated elimination of activated autoreactive T cells through a mutation that interrupts the interaction between Qa-1(b) and CD94/NKG2A. Here we evaluate the ability of an anti-NKG2A F(ab')(2) Ab to enhance elimination of autoreactive T cells and reduce experimental autoimmune encephalomyelitis (EAE). Anti-NKG2A F(ab')(2) treatment diminishes progression of both myelin oligodendrocyte glycoprotein (MOG)-induced EAE in intact C57BL/6 mice and after adoptive transfer of disease-causing T cells. Analyses of the underlying mechanism revealed that administration of anti-NKG2A F(ab')(2) Ab reduces CD4(+) T recall responses to MOG and skews the proportion of IL-17- and IFNgamma-producing CD4(+) T cells toward the protective IL-4- and IL-10-secreting CD4(+) T cell subpopulations. CD94/NKG2A-dependent inhibition of inflammatory damage to spinal cord is associated with decreased infiltration of T cells and reduced microglia activation in the central nervous system. Because anti-NKG2A F(ab')(2) treatment had no detectable effect on the numbers or activity of T and B lymphocytes and NK cells in peripheral lymphoid tissues, this anti-NKG2A-based approach may represent a safe and effective therapy for this CNS disorder.
15년 경과한 PC PC아파트의 누수경로 조사결과 (2014)

PC apartment house 15 years have elapsed have various deteriorations by water leakage in roof and wall. The prior investigation such as investigating of leakage repair history of PC apartment and the field investigation were carried out to solve the water leak problem in its structure. The path of water was analyzed on the parts of greatest water leak such as roof parapet, roof floor, side wall, corridor and balcony. As a result, the specific path of the water leakage was identified in various structure units.
VEGF-C and aortic cardiomyocytes guide coronary artery stem development (2014)

Coronary arteries (CAs) stem from the aorta at 2 highly stereotyped locations, deviations from which can cause myocardial ischemia and death. CA stems form during embryogenesis when peritruncal blood vessels encircle the cardiac outflow tract and invade the aorta, but the underlying patterning mechanisms are poorly understood. Here, using murine models, we demonstrated that VEGF-C-deficient hearts have severely hypoplastic peritruncal vessels, resulting in delayed and abnormally positioned CA stems. We observed that VEGF-C is widely expressed in the outflow tract, while cardiomyocytes develop specifically within the aorta at stem sites where they surround maturing CAs in both mouse and human hearts. Mice heterozygous for islet 1 (Isl1) exhibited decreased aortic cardiomyocytes and abnormally low CA stems. In hearts with outflow tract rotation defects, misplaced stems were associated with shifted aortic cardiomyocytes, and myocardium induced ectopic connections with the pulmonary artery in culture. These data support a model in which CA stem development first requires VEGF-C to stimulate vessel growth around the outflow tract. Then, aortic cardiomyocytes facilitate interactions between peritruncal vessels and the aorta. Derangement of either step can lead to mispatterned CA stems. Studying this niche for cardiomyocyte development, and its relationship with CAs, has the potential to identify methods for stimulating vascular regrowth as a treatment for cardiovascular disease.
Viscoelastic properties of polymers. 4. Thermorheological complexity of the softening dispersion in polyisobutylene (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTViscoelastic properties of polymers. 4. Thermorheological complexity of the softening dispersion in polyisobutyleneD. J. Plazek, I.-C. Chay, K. L. Ngai, and C. M. RolandCite this: Macromolecules 1995, 28, 19, 6432–6436Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ma00123a007https://doi.org/10.1021/ma00123a007research-articleACS PublicationsRequest reuse permissionsArticle Views921Altmetric-Citations179LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mixed initiative interfaces for learning tasks (2001)

Applications of machine learning can be viewed as teacherstudent interactions in which the teacher provides training examples and the student learns a generalization of the training examples. One such application of great interest to the IUI community is adaptive user interfaces. In the traditional learning interface, the scope of teacher-student interactions consists solely of the teacher/user providing some number of training examples to the student/learner and testing the learned model on new examples. Active learning approaches go one step beyond the traditional interaction model and allow the student to propose new training examples that are then solved by the teacher. In this paper, we propose that interfaces for machine learning should even more closely resemble human teacher-student relationships. A teacher&apos;s time and attention are precious resources. An intelligent studentmust proactively contribute to the learning process, by reasoning about the quality of its knowledge, collaborating with the teacher, and suggesting new examples for her to solve. The paper describes a varietyof richinteraction modes that enhance the learning process and presents a decision-theoretic framework, called DIAManD, for choosing the best interaction. We apply the framework to the SMARTedit programming by demonstration system and describe experimental validation and preliminary user feedback.
MOLECULAR CHAPERONES (1991)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Automatic target recognition using a passive multisensor suite (1992)

An ongoing study of automatic target recognition using a passive multisensor suite is presented. The multisensor suite consists of electro-optical and acoustic sensors, a radio frequency interferometer, and meteorological sensors. Three feature analysis tools-a genetic algorithm, a branch-and-bound algorithm, and a new class overlap region partitioning scheme (CORPS)-are employed for assessing the effectiveness of features extracted by several data and feature fusion concepts. Dedicated hardware has been configured for laboratory and field testing. A high-resolution graphics display has been designed for monitoring the target-acquisition-related processes and maximizing information transfer to the operator.
"Mr. Eric Chess, I Presume?" (1973)

Thus, we were very pleased when the editor of The History Teacher offered us the opportunity to introduce ourselves to the journal's readers. For those of you who are not already acquainted with the ERIC system in general and ERIC/ChESS in particular, ERIC stands for Educational Resources Information Center and ChESS stands for Clearinghouse for Social Studies/Social Science Education. We provide a variety of information services to teachers, administrators, researchers, curriculum developers, and many other sorts of people involved in education. ERIC was conceived in the mid-1960s, was developed under the auspices of the U.S. Office of Education, and is now administered by the recently established National Institute of Education. Its purpose is to provide systematic access to high-quality, but difficult-to-obtain literature related to all aspects of education. It concentrates especially on obtaining and indexing fugitive documents-curriculum guides and materials, research and evaluation reports, and other documents that have not become available to a wide and interested audience because of publishing or distribution barriers. These are the thousands of documents previously read only by financial officers of funding agencies, and a small circle of colleagues and friends of the authors.
Synthese und Charakterisierung von 1,3,5-Hexahydrotriazin-Komplexen des Mo<sup>o</sup> und Mo<sup>VI</sup> / Synthesis and Characterization of 1,3,5-Hexahydrotriazine Complexes of Mo<sup>0</sup> and M o<sup>VI</sup> (1995)

Organo-substituted 1,3,5-hexahydrotriazine complexes of the type (RNCH 2 ) 3 Mo(CO) 3 (R = CH 3 , i - C 3 H 7 and CH 2 C 6 H 5 ) are obtained by ligand displacement from η 6 -C 7 H 8 Mo(CO) 3 in high yields. These products have been characterized by 1 H, 13 C, 95 Mo NMR, IR as well as mass spectroscopy and contain an electron-rich Mo(C O) 3 center bonded to the 1,3,5-hexahydrotriazine 6e donor via three Mo -N bonds. Oxidation of the Mo 0 complex 1,3,5-(CH 3 NCH 2 ) 3 Mo(CO) 3 with H 2 O 2 under carefully controlled conditions allows isolation of 1,3,5-(CH 3 NCH 2 ) 3 MoO 3 containing a Mo VI center. Chemical and spectroscopic properties of these complexes are compared with those of related Mo complexes with neutral macrocyclic ligands containing N 3 donor sets.
Efficiently updating materialized views (1986)

Query processing can be sped up by keeping frequently accessed users' views materialized. However, the need to access base relations in response to queries can be avoided only if the materialized view is adequately maintained. We propose a method in which all database updates to base relations are first filtered to remove from consideration those that cannot possibly affect the view. The conditions given for the detection of updates of this type, called irrelevant updates, are necessary and sufficient and are independent of the database state. For the remaining database updates, a differential algorithm can be applied to re-evaluate the view expression. The algorithm proposed exploits the knowledge provided by both the view definition expression and the database update operations.
Classifier and feature set ensembles for web page classification (2015)

Web page classification is an important research direction on web mining. The abundant amount of data available on the web makes it essential to develop efficient and robust models for web mining tasks. Web page classification is the process of assigning a web page to a particular predefined category based on labelled data. It serves for several other web mining tasks, such as focused web crawling, web link analysis and contextual advertising. Machine learning and data mining methods have been successfully applied for several web mining tasks, including web page classification. Multiple classifier systems are a promising research direction in machine learning, which aims to combine several classifiers by differentiating base classifiers and/or dataset distributions so that more robust classification models can be built. This paper presents a comparative analysis of four different feature selections (correlation, consistency, information gain and chi-square-based feature selection) and four different ensemble learning methods (Boosting, Bagging, Dagging and Random Subspace) based on four different base learners (naive Bayes, K-nearest neighbour algorithm, C4.5 algorithm and FURIA algorithm). The article examines the predictive performance of ensemble methods for web page classification. The experimental results indicate that feature selection and ensemble learning can enhance the predictive performance of classifiers in web page classification. For the DMOZ-50 dataset, the highest average predictive performance (88.1%) is obtained with the combination of consistency-based feature selection with AdaBoost and naive Bayes algorithms, which is a promising result for web page classification. Experimental results indicate that Bagging and Random Subspace ensemble methods and correlation-based and consistency-based feature selection methods obtain better results in terms of accuracy rates.
Nonparametric identification of discriminative information in body surface maps (1991)

A nonparametric method, based on the Kolmogorov-Smirnov (K-S) test was used to detect significant differences between classes of body surface maps (BSPM's). By systematic application of the method throughout the cardiac cycle, discriminative spatio-temporal information can be identified. In a second method, a Sebestyen linear transformation (SLT) was derived to give estimates of pairwise, linear separability of clinical classes. The utility of the method was illustrated by the pairwise comparison of 40 normal subjects (NOR), 40 patients with anterior myocardial infarction (AMI), and 40 with inferior myocardial infarction (IMI). The application examples demonstrated that: a) diagnostic information in low potential amplitude regions may surpass that in high amplitude regions, b) probability distributions of characteristic features showed small overlap in NOR versus AMI and NOR versus IMI dichotomies although they were not linearly separable, and c) the single best separating potential sample in the K-S sense for NOR versus AMI or NOR versus IMI dichotomies recovered 88 and 73% of the SLT performance, respectively.
318. The constitution of yohimbine and related alkaloids. Part IV. A synthesis of yohimbone (1950)

G. A. Swan, J. Chem. Soc., 1950, 1534 DOI: 10.1039/JR9500001534
Datos normativos sobre aspectos psicológicos del desarrollo y de la escolaridad de la muestra de estandarización de la EIWIN-R de Puerto Rico (1992)

El proyecto para la adaptación y la normalización de la Escala de Inteligencia Wechsler para Niños, Revisada de Puerto Rico se inició en el 1987 y se completó en diciembre de 1991. La información pertinente a las características psicométricas del instrumento se presentan en el Manual de Instrucciones de la escala y en el Informe Final del proyecto EIWN-R de Puerto Rico que redactaron las autoras. (enero de 1992)
Proteases involved in generation of beta- and alpha-amylases from a large amylase precursor in Bacillus polymyxa (1991)

The genes for extracellular neutral protease (Npr) and intracellular serine protease (Isp) were cloned from Bacillus polymyxa in order to elucidate the process involved in the generation of multiple beta-amylases and an alpha-amylase from a large amylase precursor. The npr gene was composed of 1,770 bp and 570 amino acids, while the isp gene was composed of 978 bp and 326 amino acids. Both proteases produced by E. coli cleaved the amylase precursor to generate beta- and alpha-amylases. Furthermore, several other proteases produced the same products from the precursor. A 130-kDa amylase precursor has two large domain structures responsible for the generation of beta- and alpha-amylases. The junction region of approximately 200 amino acids may be exposed on the surface of the molecule and susceptible to proteolytic enzymes, which results in the formation of multiple amylases.
The Future of Autonomous Vehicle Technology as a Public Safety Tool (2015)

Every year, clever people with wonderfully innovative ideas bring legislation to their state capitols and to Congress. They have great hope that their innovations will make the world a better place. It does not always work out. Often these smart people can be seen standing in the corridor outside meeting rooms whispering to each other anxiously. They have looks of shock and disappointment on their faces, usually just after their bill was unceremoniously disemboweled in a committee hearing. The legislative process necessarily is one of compromise, and few competing interests demand more compromise than those brought to the table by Public Safety and Homeland Security representatives. This Article is a satirical exploration of how autonomous vehicle regulation may unfold in public policy forums over the next few decades. The piece will be perceived as dystopian by some, utopian by others.