gebhart/patrepeval huggingface dataset:
Towards data sharing economy on Internet of Things: a semantic for telemetry data (2022)

Abstract Internet of Things (IoT) provides data processing and machine learning techniques with access to physical world data through sensors, namely telemetry data. Acquiring sensor data through IoT faces challenges such as connectivity and proper measurement requiring domain-specific knowledge, that results in data quality problems. Data sharing is one solution to this. In this work, we propose IoT Telemetry Data Hub (IoT TeleHub), a general framework and semantic for telemetry data collection and sharing. The framework is principled on abstraction, layering of elements, and extensibility and openness. We showed that while the framework is defined specifically for telemetry data, it is general enough to be mapped to existing IoT platforms with various use cases. Our framework also considers the machine-readable and machine-understandable notion in regard to resource-constrained IoT devices. We also present IoThingsHub, an IoT platform for real-time data sharing based on the proposed framework. The platform demonstrated that the framework could be implemented with existing technologies such as HTTP, MQTT, SQL, NoSQL.
Optimization of detection networks. II. Tree structures (1993)

A distributed binary detection problem with multimessage (>or=1 bit) communications is considered, wherein the nodes (sensors, decision-makers (DMs)) of the system are organized in the form of a tree with multiple root nodes. A numerical algorithm is developed for determining the optimal decision rule at each node assuming monotone cost functions imposed only on the root nodes. It is assumed that the observations of each node are conditionally independent of those of the other nodes. It is shown that the problem is equivalent to solving a nonlinear optimal control problem, and the necessary conditions of optimality using Bayes' risk as the optimization criterion are derived. The optimal control approach provides an interpretation of certain functions of the co-state variables in terms of thresholds, and leads to a computationally efficient min-H algorithm to solve for the optimal decision rule at each node. The numerical algorithm provides a tool to investigate the organizational issues of adaptation, structure, and robustness.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Fourier–Mellin transform and mammalian hearing (1978)

A combined Fourier–Mellin transform yields a representation of a signal that is independent of delay and scale change. Such a representation should be useful for speech analysis, where delay and scale differences degrade the performance of correlation operations or other similarity measures. At least two different versions of a combined Fourier–Mellin transform can be implemented. The simplest version (the ‖F‖2−‖M‖2 transform) completely eliminates spectral phase information, while a slightly more complicated version (the ?−? transform) preserves some phase information. Both versions can be synthesized with a Fourier transform and an exponential-sampling algorithm. Exponential sampling produces a frequency scale distortion that is similar to the effect of the cochlea. The ‖F‖2−‖M‖2 transform can also be implemented with a bank of proportional bandwidth filters. If the relative phase between spectral components is preserved, then a Fourier–Mellin transformer can perform compression of linear-period modulated signals. Such signals are used for echolocation by bats and cetaceans. The same approach that gives scale and delay invariance can be used to obtain other transform conbinations that provide insensitivity to a variety of distortions. The combined transforms can also be used for analyzing these distortions.
A<sub>1</sub>adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion (2004)

Controversy exists regarding the effect of A1 adenosine receptor (AR) activation in the kidney during ischemia and reperfusion (I/R) injury. We sought to further characterize the role of A1 ARs in modulating renal function after I/R renal injury using both pharmacological and gene deletion approaches in mice. A1 AR knockout mice (A1KO) or their wild-type littermate controls (A1WT) were subjected to 30 min of renal ischemia. Some A1WT mice were subjected to 30 min of renal ischemia with or without pretreatment with 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) or 2-chrolo-cyclopentyladenosine (CCPA), selective A1 AR antagonist and agonist, respectively. Plasma creatinine and renal histology were compared 24 h after renal injury. A1KO mice exhibited significantly higher creatinines and worsened renal histology compared with A1WT controls following renal I/R injury. A1WT mice pretreated with the A1 AR antagonist or agonist demonstrated significantly worsened or improved renal function, respectively, after I/R injury. In addition, A1WT mice pretreated with DPCPX or CCPA showed significantly increased or reduced markers of renal inflammation, respectively (renal myeloperoxidase activity, renal tubular neutrophil infiltration, ICAM-1, TNF-alpha, and IL-1beta mRNA expression), while demonstrating no differences in indicators of apoptosis. In conclusion, we demonstrate that endogenous or exogenous preischemic activation of A1 ARs protects against renal I/R injury in vivo via mechanisms leading to decreased necrosis and inflammation.
Permeability of Membranes to the Müllerian-Inhibiting Substance Synthesized by the Human Fetal Testis<i>in Vitro</i>: A Clue to its Biochemical Nature (1972)

The ability of the human fetal testis to inhibit the müllerian duct of the 14½-day-old fetal rat, in organ culture has been already reported. In this study, membranes were inserted between the human fetal testis and its target-organ. Müllerian inhibition proceeded normally when the rat reproductive tract was separated from the human fetal testis by the vitelline membrane of a hen's egg, thus proving that direct contact between the two organs is not necessary to the activity of the müllerian-inhibiting substance. In contrast, no inhibition of the müllerian duct took place when this structure was separated from the fetal testis by Visking cellulose, a membrane permeable to molecules under 15.000 of molecular weight. Control experiments showed that 16½-day-old androgen-dependent wolffian ducts are maintained when separated from rat fetal testes by this same membrane. Our data indicate that the müllerian-inhibiting substance is not a steroid in free form. They are compatible with the hypothesis that the müllerian-inhibiting activity is supported by a macromolecule.
Process Control: Designing Processes and Control Systems for Dynamic Performance (1995)

1 Introduction to Process Control 2 Control Objectives and Benefits 3 Mathematical Modeling Principles 4 Modeling and Analysis for Process Control 5 Dynamic Behavior of Typical Process Systems 6 Empirical Model Identification 7 The Feedback Loop 8 The Proportional-Integral-Derivative (PID) Algorithm 9 PID Controller Tuning for Dynamic Performance 10 Stability Analysis and Controller Tuning 11 Digital Implementation of Process Control 12 Practical Application of Feedback Control 13 Performance of Feedback Control Systems 14 Cascade Control 15 Feedforward Control 16 Adapting Single-Loop Control Systems for Non-Linear Processes 17 Inferential Control 18 Level and Inventory Control 19 Single-Variable Model Predictive Control 20 Multiloop ControlEffects of Interaction 21 Multiloop Control Performance Analysis 22 Variable Structure and Constraint Control 23 Centralized Multivariable Control 24 Process Control Design Definition and Decisions 25 Process Control Design Managing the Design Procedure 26 Control for Product Quality and Profit Appendices
Irradiation reduces interstitial fluid transport and increases the collagen content in tumors. (2003)

After irradiation, the decrease in K and increase in collagen type I levels could significantly hinder the convective movement and diffusion of large therapeutic agents in tumors.
A Flexible Approach to Improving System Reliability with Virtual Lockstep (2010)

There is an increasing need for fault tolerance capabilities in logic devices brought about by the scaling of transistors to ever smaller geometries. This paper presents a hypervisor-based replication approach that can be applied to commodity hardware to allow for virtually lockstepped execution. It offers many of the benefits of hardware-based lockstep while being cheaper and easier to implement and more flexible in the configurations supported. A novel form of processor state fingerprinting is also presented, which can significantly reduce the fault detection latency. This further improves reliability by triggering rollback recovery before errors are recorded to a checkpoint. The mechanisms are validated using a full prototype and the benchmarks considered indicate an average performance overhead of approximately 14 percent with the possibility for significant optimization. Finally, a unique method of using virtual lockstep for fault injection testing is presented and used to show that significant detection latency reduction is achievable by comparing only a small amount of data across replicas.
ChemInform Abstract: A New Method for the Preparation of 3‐Alkoxy‐ and 3‐Hydroxy‐3,4‐dihydro‐1H‐2‐benzopyrans. (1990)

Abstract 2‐Bromobenzaldehyde (I) is olefinated with the Wittig reagent (II) and then treated with methanol (IV) to give the acetal (V).
Theoretical and Computational Protein Design (2011)

From exponentially large numbers of possible sequences, protein design seeks to identify the properties of those that fold to predetermined structures and have targeted structural and functional properties. The interactions that confer structure and function involve intermolecular forces and large numbers of interacting amino acids. As a result, the identification of sequences can be subtle and complex. Sophisticated methods for characterizing sequences consistent with a particular structure have been developed, assisting the design of novel proteins. Developments in such computational protein design are discussed, along with recent accomplishments, ranging from the redesign of existing proteins to the design of new functionalities and nonbiological applications.
Clinical Cardiac Tolerability of Trastuzumab (2004)

Trastuzumab is associated with an increased risk of asymptomatic decreases in ejection fraction, and, in a small number of patients, CHF that is almost always responsive to medical management. This risk is greatest in patients receiving concurrent anthracyclines. More data are needed to help elucidate the pathophysiology of this syndrome.
Myocardial Necrosis from Direct Current Countershock (1974)

The effect of varying both paddle electrode size and the time interval between direct current countershock on myocardial necrosis was studied. Forty-two dogs were divided into seven groups of six dogs each. All dogs were given ten consecutive, 240 watt-second countershocks (delivered energy into a 50 ohm load). Three groups were shocked with paddle electrode diameters of 8.0 cm (standard electrodes), two groups with paddle electrode diameters of 12.8 cm (large electrodes), and two groups with paddle electrode diameters of 4.3 cm (small electrodes). The time intervals between discharges in the groups shocked with the standard electrodes were 15 seconds, one minute, and three minutes. The time interval between discharges in the groups shocked with small and large electrodes was 15 seconds and three minutes. Myocardial necrosis was quantitated by precordial electrocardiographic mapping recorded minutes after, and by gross and microscopic examination of the hearts four days after direct current countershock. When the time interval between discharges was shorter, myocardial necrosis was greater. When the time interval between discharges was constant, more necrosis was produced with smaller-sized paddle electrodes. It is concluded that large paddle electrodes should be used for delivering direct current countershocks, and that during elective cardioversion, consecutive discharges should be delivered at time intervals greater than three minutes.
Diversity in MHC class II antigen presentation (2002)

Processing exogenous and endogenous proteins for presentation by major histocompatibility complex (MHC) molecules to T cells is the defining function of antigen-presenting cells (APC) as major regulatory cells in the acquired immune response. MHC class II-restricted antigen presentation to CD4 T cells is achieved by an essentially common pathway that is subject to variation with regard to the location and extent of degradation of protein antigens and the site of peptide binding to MHC class II molecules. These subtle variations reveal a surprising flexibility in the ways a diverse peptide repertoire is displayed on the APC surface. This diversity may have profound consequences for the induction of immunity to infection and tumours, as well as autoimmunity and tolerance.
HandsDown (2010)

HandsDown is a novel technique for user identification on interactive surfaces. It enables users to access personal data on a shared surface, to associate objects with their identity, and to fluidly customize appearance, content, or functionality of the user interface. To identify, users put down their hand flat on the surface. HandsDown is based on hand contour analysis; neither user instrumentation nor external devices are required for identification. Characteristic features of the hand are initially extracted from images captured by the surface's camera system and then classified using Support Vector Machines (SVM).
Bioadhesive nanoareas in antifouling matrix for highly efficient affinity sensors (2008)

A procedure for fabricating nanopatterned surfaces at the sub-500 nm scale comprising a hexagonal close packed array of bioadhesive gold nanoareas in a protein resistant matrix (PEO-like polymer), has been optimized. The surfaces were characterized by AFM analysis and their interaction with amino functionalised gold nanoparticles as models were investigated. The AFM images show the crystalline arrangement of nanopattern array and the localized adsorption of the H2N-Au nanoparticles in the bioadhesive nanoareas. A Surface Plasmon Resonance imaging (SPRi) system was used to assess the detection performances of these surfaces when employed as a transduction platform for studying biomolecule interactions. The investigated surfaces showed an enhancement of the affinity reaction efficiency with respect to the non structured surfaces. The obtained preliminary results show that nanostructuring the surfaces improve the binding site accessibility of the immobilized biological probes without significantly modifying the native biomolecule conformation.
A tutorial on calibration measurements and calibration models for clinical prediction models (2020)

Our primary objective is to provide the clinical informatics community with an introductory tutorial on calibration measurements and calibration models for predictive models using existing R packages and custom implemented code in R on real and simulated data. Clinical predictive model performance is commonly published based on discrimination measures, but use of models for individualized predictions requires adequate model calibration. This tutorial is intended for clinical researchers who want to evaluate predictive models in terms of their applicability to a particular population. It is also for informaticians and for software engineers who want to understand the role that calibration plays in the evaluation of a clinical predictive model, and to provide them with a solid starting point to consider incorporating calibration evaluation and calibration models in their work. Covered topics include (1) an introduction to the importance of calibration in the clinical setting, (2) an illustration of the distinct roles that discrimination and calibration play in the assessment of clinical predictive models, (3) a tutorial and demonstration of selected calibration measurements, (4) a tutorial and demonstration of selected calibration models, and (5) a brief discussion of limitations of these methods and practical suggestions on how to use them in practice.
Corrosion of cast iron in concentrated sulphuric acid under potentiostatic conditions (1966)

AbstractPolarisation curves and corrosion rates have been determined for grey cast iron in 96 wt.-% sulphuric acid at temperatures varying from room temperature to the boiling point. For boiling acid, the polarisation curves have been determined in the concentration range from 90 to 100 wt.-% acid and in 96 wt.-% acid after addition of organic impurities. The polarisation curves show that grey cast iron corrodes in an active manner at the lower temperatures, but at temperatures higher than about 220° the cast iron will behave as a passive metal in the pure 96wt.-%acid. Dilution of the acid to about 93 wt.-% or the presence of reducing impurities results in an active corrosion potential. The corrosion rate in boiling acid has been measured under potentiostatic conditions, and the corrosion rate is shown to vary by a factor of 1000 by variation of the corrosion potential in a range of 300 mV.
Progress and problems in the biology, diagnostics, and therapeutics of prion diseases (2004)

The term "prion" was introduced by Stanley Prusiner in 1982 to describe the atypical infectious agent that causes transmissible spongiform encephalopathies, a group of infectious neurodegenerative diseases that include scrapie in sheep, Creutzfeldt-Jakob disease in humans, chronic wasting disease in cervids, and bovine spongiform encephalopathy in cattle. Over the past twenty years, the word "prion" has been taken to signify various subtly different concepts. In this article, we refer to the prion as the transmissible principle underlying prion diseases, without necessarily implying any specific biochemical or structural identity. When Prusiner started his seminal work, the study of transmissible spongiform encephalopathies was undertaken by only a handful of scientists. Since that time, the "mad cow" crisis has put prion diseases on the agenda of both politicians and the media. Significant progress has been made in prion disease research, and many aspects of prion pathogenesis are now understood. And yet the diagnostic procedures available for prion diseases are not nearly as sensitive as they ought to be, and no therapeutic intervention has been shown to reliably affect the course of the diseases. This article reviews recent progress in the areas of pathogenesis of, diagnostics of, and therapy for prion diseases and highlights some conspicuous problems that remain to be addressed in each of these fields.
Stimulation of Plasmodium falciparum gametocytogenesis by conditioned medium from parasite cultures. (1999)

Plasmodium falciparum gametocyte development was examined in erythrocyte monolayer cultures prepared with Cell-Tak, a cell and tissue adhesive. The monolayers, which were stable for up to 10 days in culture, supported multiple cycles of asexual growth and the development of clusters of stage IV gametocytes. Small numbers of chicken erythrocytes incorporated into the monolayers served as internal reference standards for parasite counts. This permitted quantitative assessment of gametocyte formation under different culture conditions. Gametocyte formation was limited in monolayers grown in standard culture medium but it increased slightly in monolayers cocultured with suspensions of parasitized erythrocytes. The number of gametocytes increased significantly in monolayers grown in parasite-conditioned medium. In both cases the changes resulted from increased numbers of stage II and III gametocytes in the monolayers. These results suggest that parasite conditioned medium contains a factor(s) that stimulates sexual development.
Three‐dimensional structure of moenomycin A (1998)

The first three-dimensional structure of moenomycin A in aqueous solution based on NMR-derived distance constraints and molecular dynamics simulations is presented. The antibiotic moenomycin A was obtained from the FlavomycinR complex by ultrafiltration, chromatography on a DEAE-cellulose ion exchanger and reverse-phase chromatography in 98% purity. In contrast to the previously reported behaviour, the compound gave rise to well-resolved NMR spectra in standard solvents. Using several two-dimensional experiments, a complete assignment of proton and carbon chemical shifts was achieved in (CD3)2SO, CD3OD and H2O/D2O (9:1, pH 7.3). A total of 175 interproton distances were determined from 600-MHz rotating-frame NOE (ROE) spectra and were used as restraints in molecular dynamics calculations. These restraints included 84 ROEs between protons of the moenocinol part leading to a very well-defined structure of the lipid part of the molecule. The relative orientation of the subunits was determined by 66 ROEs among different sugar rings and between the sugar rings and moenocinol. As a result of the molecular dynamics calculation, rings D, E, and F as well as the moenocinol part are very well-defined (average rms deviation over all heavy atoms 0.48 A) whereas rings A, B and C display a higher degree of conformational flexibility which might be an artefact due to the lower number of ROEs in this part of the molecule. A three-dimensional pharmacophore hypothesis comprising functional groups of rings E and F and the carboxyl group of glyceric acid is presented on the basis of the degradation and derivatization studies of Welzel and coworkers [Welzel, P., Kunisch, F., Kruggel, F., Stein, H., Scherkenbeck, J., Hiltmann, A., Duddeck, H., Müller, D., Maggio, J. E., Fehlhaber, H.-W., Seibert, G., van Heijenoort, Y. & van Heijenoort, J. (1987) Moenomycin A: Minimum structural requirements for biological activity, Tetrahedron 43, 585-598; Welzel, P. (1993) Transglycosylase inhibition, in Antibiotics and antiviral compounds--Chemical synthesis and modifications (Krohn, K., Kirst, H. A. & Maag, H., eds) pp. 373-378, VCH Weinheim].
A new reaction of fullerenes: [2+2]-photocycloaddition of enones (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new reaction of fullerenes: [2+2]-photocycloaddition of enonesStephen R. Wilson, Nikolas Kaprinidis, Yunhui Wu, and David I. SchusterCite this: J. Am. Chem. Soc. 1993, 115, 18, 8495–8496Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ja00071a088https://doi.org/10.1021/ja00071a088research-articleACS PublicationsRequest reuse permissionsArticle Views328Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Manual de Twitter 2013 (2013)

Manual de Twitter\n\nSegundo módulo de 6 del curso de Redes Sociales aplicadas al ámbito universitario, en el que se explica el uso de Twitter.