gebhart/patrepeval huggingface dataset:
Experiments with sub-band acoustic echo cancellers for teleconferencing (2005)

Future teleconferencing systems will use wide-band speech and will include acoustic echo control devices to achieve a sufficient quality. The classical echo cancellation algorithms involve an important amount of computations, due to the large adaptive filters identifying the impulse response of the echo path. The sub-band processing approach appears to be a reasonable way to reduce this computational burden, and it affords several other advantages. Two variants of sub-band echo cancellers havebeen implemented and tested: one is based on the two-band splitting of the speech spectrum by a QMF (Quadrature Mirror Filters) pair; the other uses pseudo-QMF banks to achieve the best reduction of the global computations. Performances obtained with both systems are reported. Main degradations due to critical sub-sampling in the pseudo-QMF banks are pointed out and illustrated. Finally, some solutions offering compromises between complexity and performances are proposed.
Serving up food safety: who wants a piece of the pie? (2001)

A total of 12 federal agencies, plus their state counterparts, contribute to the regulatory snarl that governs the safety of the American food supply. With so much federal oversight, one might expect U.S. foods to be virtually risk-free. But this is hardly the case; contaminated food is responsible for 75 million illnesses, 325,000 hospitalizations, and 5,000 deaths in the United States each year. Recent reports from the General Accounting Office and the National Research Council claim that creation of a single agency with centralized authority is the best solution to U.S. food safety problems. Some experts agree that regulatory gaps in food safety highlight the need for centralized leadership, and that more money is necessary to fund the number of inspectors needed to adequately inspect the food supply before it reaches consumers. The single-agency concept has garnered congressional, industry, and scientific support, but the idea isn't without its skeptics, who believe that consolidating food safety under a single agency eliminates checks and balances offered by the current system and, more importantly, runs the risk of politicizing the agency.
High-power drive system with advanced power circuitry and improved digital control (1993)

A drive system featuring a three-level inverter (which is also known as a neutral-point-clamped inverter) and offering new features is introduced. The circuit concept not only makes it possible to expand the power range without connecting GTOs directly in series or parallel, but it also greatly improves the voltage and current waveforms, enhances control properties, and reduces losses. In addition, this drive system features a self-commutated GTO converter on the line side. It permits free energy exchange in both directions without reactive power and with a low harmonic content of the line current. Digital, signal-processor-based vector control and new PWM methods for both convertors are ideally suited for steady-state operation as well as for conditions demanding high dynamic performance. The results of a system test in the megawatt range underscore the qualities of this drive system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes. (1994)

Intracellular sugars are more reactive glycosylating agents than glucose. In vitro nonezymatic glycosylation of basic fibroblast growth factor (bFGF) by fructose, glucose-6-phosphate (G6P), or glyceraldehyde-3-phosphate (G3P) reduced high affinity heparin-binding activity of recombinant bFGF by 73, 77, and 89%, respectively. Mitogenic activity was reduced 40, 50, and 90%. To investigate the effects of bFGF glycosylation in GM7373 endothelial cells, we first demonstrated that GLUT-1 transporters were not downregulated by increased glucose concentration. In 30 mM glucose, the rate of glucose transport increased 11.6-fold, and the intracellular glucose concentration increased sixfold at 24 h and fivefold at 168 h. The level of total cytosolic protein modified by advanced glycosylation end-products (AGEs) was increased 13.8-fold at 168 h. Under these conditions, mitogenic activity of endothelial cell cytosol was reduced 70%. Anti-bFGF antibody completely neutralized the mitogenic activity at both 5 and 30 nM glucose, demonstrating that all the mitogenic activity was due to bFGF. Immunoblotting and ELISA showed that 30 mM glucose did not decrease detectable bFGF protein, suggesting that the marked decrease in bFGF mitogenic activity resulted from posttranslational modification of bFGF induced by elevated glucose concentration. Cytosolic AGE-bFGF was increased 6.1-fold at 168 h. These data are consistent with the hypothesis that nonenzymatic glycosylation of intracellular protein alters vascular cell function.
Meteorological conditions processing for vision-based traffic monitoring (2004)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et a ̀ la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease. (1992)

The authors have previously shown that amyloid precursor protein (APP) accumulates in neurites present in senile plaques of Alzheimer's disease (AD). In this ultrastructural immunocytochemical study, we describe the subcellular site of APP accumulation. Vibratome sections of glutaraldehyde-paraformaldehyde fixed hippocampi from five cases of AD were pretreated with methanol and immunostained with an antibody raised against recombinant APP 770 by using either indirect immunogold or peroxidase methods. Immunolabeling was localized in cell processes filled with amorphous, irregular-shaped materials, which were identified as dense bodies deformed by postmortem autolysis and methanol treatment, as well as multilamellar membranous bodies. Identification of these bodies was obtained with comparative ultrastructural examination of biopsy and autopsy tissue fixed with and without methanol treatment. These electron-dense organellae were positive for the lysosomal marker, acid phosphatase. At light microscopy, acid phosphatase and APP colocalized to the same cell processes in senile plaques. Many of those cell processes contained abnormal straight or paired helical filaments supporting their neuritic nature. These results suggest that APP accumulates in the lysosomal system of the dystrophic neurites present in senile plaques and are consistent with a neuronal origin of the APP forming the amyloid in senile plaques.
Development of a Ligand-Directed Approach To Study the Pathogenesis of Invasive Aspergillosis (2005)

Invasive aspergillosis is a leading cause of infectious death in immunosuppressed patients. Here, we adapted a phage display library-based selection to screen and identify binding peptides to the surface of Aspergillus fumigatus conidia and hyphae. We identified a peptide (sequence CGGRLGPFC) that reliably binds to the surface of Aspergillus fumigatus hyphae. Binding was not Aspergillus strain specific, as it was also observed in hyphae of other Aspergillus clinical isolates. Furthermore, CGGRLGPFC-displaying phage targets Aspergillus fumigatus hyphae on formalin-fixed paraffin-embedded histopathology sections of lung tissue recovered from mice with invasive pulmonary aspergillosis. This approach may yield reagents such as peptidomimetics for novel diagnostic and therapeutic interventions in invasive aspergillosis.
Interleukin-7 Enhances Proliferation Responses to T-Cell Receptor Stimulation in Naive CD4 <sup>+</sup> T Cells from Human Immunodeficiency Virus-Infected Persons (2007)

Proliferation responses of naïve CD4(+) T cells to T-cell receptor and interleukin-7 (IL-7) stimulation were evaluated by using cells from human immunodeficiency virus-positive (HIV(+)) donors. IL-7 enhanced responses to T-cell receptor stimulation, and the magnitude of this enhancement was similar in cells from healthy controls and from HIV(+) subjects. The overall response to T-cell receptor stimulation alone or in combination with IL-7, however, was diminished among viremic HIV(+) donors and occurred independent of antigen-presenting cells. Frequencies of CD127(+) cells were related to the magnitudes of proliferation enhancement that were mediated by IL-7. Thus, IL-7 enhances but does not fully restore the function of naïve CD4(+) T cells from HIV-infected persons.
Quantitative Measurement of C <sub>6</sub> Antibody following Antibiotic Treatment of <i>Borrelia burgdorferi</i> Antibody-Positive Nonclinical Dogs (2007)

The detection of antibody to the Borrelia burgdorferi C6 peptide by use of enzyme-linked immunoassays is a widely accepted method for the diagnosis of Lyme disease spirochete infection in dogs and in humans. Antibody to the C6 peptide is highly specific for B. burgdorferi and declines following treatment of dogs and humans exposed to B. burgdorferi. A quantitative assay for determining C6 antibody levels was developed and used to measure changes in antibody levels following antibiotic treatment of B. burgdorferi antibody-positive nonclinical dogs. One hundred thirty-two client-owned dogs were used in the study; 64 were negative, 53 of 68 positive animals received treatment, and 15 were untreated controls. Test sera were collected at 3, 6, and 12 months from seropositive dogs receiving treatment and untreated controls. Dogs in the treated group were assigned to moderate-to-high (> or =29 U/ml)- and low (<29 U/ml)-C6-level groups because the change in the C6 level after treatment was dependent on the level prior to treatment. There were significant declines in the 30 dogs with moderate-to-high initial C6 levels that exceeded the maximal declines of the untreated control dogs in all cases at 6 months (16 data points) and 12 months (29 data points) posttreatment. There was little change in C6 level following antibiotic therapy in the 23 dogs with low initial C6 levels. The quantitative C6 antibody test can be used to measure changes in C6 antibody levels following treatment of antibody-positive nonclinical dogs.
Solid-Phase Synthesis of Tetrahydro-1,4-benzodiazepine-2-one Derivatives as a β-Turn Peptidomimetic Library (2004)

The beta-turn has been implicated as an important conformation for biological recognition of peptides or proteins. We adapted the concept of general Calpha atom positioning from the cluster analysis and recombination of each ideal beta-turn conformation pattern by Garland and Dean (J. Comput.-Aided Mol. Des. 1999, 13, 469) as one strategy of designing non-peptide beta-turn scaffolds. Herein, the Calpha positions of tetrahydro-1,4-benzodiazepin-2-one scaffold were analyzed after the calculation of the low-energy conformer using a semiempirical protocol. Three points of corresponding Calpha carbons for diverse substitutions in the scaffold were designated, and an efficient solid-phase synthesis of the peptidomimetic library was developed. The scaffold itself was synthesized in solution phase starting from 5-hydroxy-2-nitrobenzaldehyde and loaded to the 4-formyl-3,5-dimethoxyphenoxy (PL-FDMP) resin with high efficiency of reductive amination. Various building blocks for the derivatization of the 7-hydroxyl and N-1 amide nitrogen could be introduced via selective alkylation. Cleavage, parallel column chromatography, and NMR analysis of 62 final compounds confirmed the feasibility of this peptidomimetic library synthesis.
PARP Inhibitors in Epithelial Ovarian Cancer (2017)

PARP inhibitors have emerged as an exciting new drug class in the treatment of epithelial ovarian cancer. Ongoing studies are aimed at improving our ability to identify ideal candidates for PARP inhibitor therapy, as well as to identify and target mechanisms of drug resistance, and novel combinatorial approaches.
Membrane Lipid Integrity Relies on a Threshold of ATP Production Rate in Potato Cell Cultures Submitted to Anoxia1 (1999)

In this paper we report on our study of the changes in biomass, lipid composition, and fermentation end products, as well as in the ATP level and synthesis rate in cultivated potato (Solanum tuberosum) cells submitted to anoxia stress. During the first phase of about 12 h, cells coped with the reduced energy supply brought about by fermentation and their membrane lipids remained intact. The second phase (12-24 h), during which the energy supply dropped down to 1% to 2% of its maximal theoretical normoxic value, was characterized by an extensive hydrolysis of membrane lipids to free fatty acids. This autolytic process was ascribed to the activation of a lipolytic acyl hydrolase. Cells were also treated under normoxia with inhibitors known to interfere with energy metabolism. Carbonyl-cyanide-4-trifluoromethoxyphenylhydrazone did not induce lipid hydrolysis, which was also the case when sodium azide or salicylhydroxamic acid were fed separately. However, the simultaneous use of sodium azide plus salicylhydroxamic acid or 2-deoxy-D-glucose plus iodoacetate with normoxic cells promoted a lipid hydrolysis pattern similar to that seen in anoxic cells. Therefore, a threshold exists in the rate of ATP synthesis (approximately 10 &mgr;mol g-1 fresh weight h-1), below which the integrity of the membranes in anoxic potato cells cannot be preserved.
Adsorption of polyamides and polyamide–silane mixtures at glass surfaces (2003)

Abstract The individual and combined adsorption behavior of polyamides and two different silanes to multicomponent glass surfaces was probed with a combination of x‐ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and static contact angle measurements. Samples were analyzed with and without solvent rinsing to separate the weakly bound (physisorbed) and more strongly bound (chemisorbed) species. High‐resolution XPS on N 1s revealed that the polyamides adsorb to the glass surfaces via protonated amine species at the acidic (OH) sites on the glass surface. Angle‐resolved XPS confirmed this by showing that the alkyl portion of the polymer is oriented away from the glass interface. In competitive coadsorption studies it was found that amino‐terminated silanes preferentially adsorb to the glass surface, relegating the polyamide to a physisorbed outer layer. When mercaptoterminated silanes were competitively coadsorbed the polyamide was preferentially adsorbed even when present at a concentration twenty times less than that of the silane. Altogether, this work reveals the strong interaction between surface silanols and amino‐functionalized organics. Copyright © 2003 John Wiley & Sons, Ltd.
The Dbl Homology Domain of BCR Is Not a Simple Spacer in P210BCR-ABL of the Philadelphia Chromosome (2001)

The Dbl homology (DH) domain of BCR in P210BCR-ABL (P210/WT) has been thought to have a negative effect on the activation of BCR-ABL because P185BCR-ABL, in which this region is physically deleted, has stronger biochemical and biological activities. To study the role of the DH domain of BCR in the background of P210/WT, the region was replaced with homologous sequences derived from Dbl (P210/Dbl) or CDC24 (P210/CDC24) or with irrelevant sequences from LacZ (P210/LacZ) or luciferase (P210/Luci). Surprisingly, the abilities to transform Rat1 cells or mouse bone marrow cells and induce growth factor independence in interleukin 3-dependent mouse Ba/F3 cells were retained only in P210/Dbl. However, even P210/Dbl could not achieve the wild type level of surviving potential against genotoxins in Rat1 cells and in Ba/F3 cells. Activation of Akt correlated with the biological changes in Rat1 cells but did not correlate with the biological changes in Ba/F3 cells. The DH domain was not tyrosine-phosphorylated in vitro, nor could we find any differences in peptide mapping between in vitro phosphorylated P210/WT and P210/Dbl. Although functions of the DH domain remain to be discovered, we propose that the DH domain makes positive contributions to P210BCR-ABL.
A Comparison of the Ability of Intra-oral and Extra-oral Fibroblasts to Stimulate Extracellular Matrix Reorganization in a Model of Wound Contraction (1996)

Intra-oral wounds, like wounds in children, demonstrate privileged healing when compared with adult wounds at extra-oral sites. This study investigated whether this preferential healing is related to an increased ability of oral mucosal fibroblasts to reorganize extracellular matrix (ECM) when compared with their dermal counterparts. ECM reorganization was investigated by means of a fibroblast-populated collagen lattice (FPCL) system. The effect of donor age was also investigated in this system. Differences in ECM reorganization and FPCL contraction were evident: FPCL contraction was more rapid by oral mucosal fibroblasts than dermal fibroblasts (p < 0.01). FPCL contraction was also greater in child (donor < 10 years) than adult (donor > 18 years) oral mucosal fibroblasts (p < 0.01). These differences were not related to phenotypic differences in cell viability (p > 0.5), DNA synthesis (p > 0.05), and cell number (p > 0.5) within the FPCLs, or cellular attachment to collagen (p > 0.07). FPCL contraction was not stimulated by the addition of conditioned medium from oral mucosal or dermal fibroblasts (p > 0.05). These data show that the significantly increased ability of oral mucosal fibroblasts to reorganize ECM in vitro, when compared with dermal fibroblasts, represents a distinct phenotypic contractile difference, rather than differences in their production of soluble mediators or cell attachment to ECM.
Accumulation of Toxic α-Synuclein Oligomer within Endoplasmic Reticulum Occurs in α-Synucleinopathy<i>In Vivo</i> (2012)

In Parkinson's disease (PD) and other α-synucleinopathies, prefibrillar α-synuclein (αS) oligomer is implicated in the pathogenesis. However, toxic αS oligomers observed using in vitro systems are not generally seen to be associated with α-synucleinopathy in vivo. Thus, the pathologic significance of αS oligomers to αS neurotoxicity is unknown. Herein, we show that, αS that accumulate within endoplasmic reticulum (ER)/microsome forms toxic oligomers in mouse and human brain with the α-synucleinopathy. In the mouse model of α-synucleinopathy, αS oligomers initially form before the onset of disease and continue to accumulate with the disease progression. Significantly, treatment of αS transgenic mice with Salubrinal, an anti-ER stress compound that delays the onset of disease, reduces ER accumulation of αS oligomers. These results indicate that αS oligomers with toxic conformation accumulate in ER, and αS oligomer-dependent ER stress is pathologically relevant for PD.
Research on Medical Information System based on Service Grid (2007)

Grid is a type of parallel and distributed system that enables the sharing,selection,and aggregation of geographically distributed autonomous resources dynamically at runtime depending on their availability,capability,performance,cost,and users quality-of-service requirements.There are many obstructs on the sharing of resource in the Integrating distributed heterogeneous systems. For Medical information system based on Service Grid,it mainly discuss the sharing problem and create the service system.The paper describes the architecture of medical information system based on Service Grid.The grid development tool-Globus tookit 3.0 and some grid-related technologies are introduced. An application on medical information system based on grid is provided.
3.6 A 6-to-600MS/s Fully Dynamic Ringamp Pipelined ADC with Asynchronous Event-Driven Clocking in 16nm (2019)

At the upper end of achievable ADC operating speeds, clocking becomes a critical performance limiter. In “deep” pipelined ADCs that contain many stages, the clock tree constitutes a highly distributed network, with parasitics and mismatch creating skew between the different branches. Sufficient margin must be included in the timing generation such that all non-overlap and causal relationships are maintained. This leads to a difficult set of design tradeoffs in terms of power, speed, jitter, and reliability. Meanwhile, although residue amplifiers have traditionally dominated the power budget in deep pipelines, recent advances such as ring amplification have improved achievable efficiencies to the point that clocking is now the primary consumer in some cases [1, 2].
Shaping Naive Users' Models of Robots' Situation Awareness (2007)

This paper addresses a so far neglected area of human-robot interaction by approaching situation awareness from the point of view of naive users. In particular, we present an investigation into which naive models of robots' capabilities users carry into the interaction, how these models influence the interaction, and which means can be taken to guide users into more realistic models and behaviours if necessary. Quantitative and qualitative investigations reveal not only considerable uncertainty about robots' situation awareness, but also significant differences in dealing with this uncertainty. Three different types of users can be distinguished on the basis of the strategies they take. Finally, we describe experiments with two means of shaping the users' models into more realistic accounts of robots' capabilities. The results suggest that verbal robot output is a powerful means for guiding users subtly, unobtrusively and online into an understanding of robots' capabilities that is more realistic and adequate than users' naive models of robots' situation awareness.
Frequency-domain motion estimation using a complex lapped transform (1993)

A frequency-domain algorithm for motion estimation based on overlapped transforms of the image data is developed as an alternative to block matching methods. The complex lapped transform (CLT) is first defined by extending the lapped orthogonal transform (LOT) to have complex basis functions. The CLT basis functions decay smoothly to zero at their end points, and overlap by 2:1 when a data sequence is transformed. A method for estimating cross-correlation functions in the CLT domain is developed. This forms the basis of a motion estimation algorithm that calculates vectors for overlapping, windowed regions of data. The overlapping data window used has no block edge discontinuities and results in smoother motion fields. Furthermore, when motion compensation is performed using similar overlapping regions, the algorithm gives comparable or smaller prediction errors than standard models using exhaustive search block matching, and computational load is lower for larger displacement ranges and block sizes.
Hydration states of an expanded phlogopite in relation to interlayer cations (1967)

Abstract A 2–20 µ fraction of phlogopite has been converted to the sodium form by use of sodium tetraphenylboron-NaCl solutions. The cation exchange capacity of the treated material increases to a maximum of about 212 m-eq/100 g, which agrees well with the K 2 O + Na 2 O content of the initial mineral. Li-, Na-, Ca-, and Mg-saturated forms have been prepared and examined by X-ray diffraction and by thernogravimetric measurements in air, in vacuo , and at progressively elevated temperatures. Hydration states corresponding to double water layers are observed for the Mg- and Ca- forms, and to single water layers for the Mg-, Ca-, Na-, and Li- forms. The numbers of water molecules per unit cell and per interlayer cation are considered for the various hydration states.