gebhart/patrepeval huggingface dataset:
ETD Allows for Native Surface Mapping of a 150 kDa Noncovalent Complex on a Commercial Q-TWIMS-TOF Instrument (2014)

Top-down approaches for the characterization of intact proteins and macromolecular complexes are becoming increasingly popular, since they potentially simplify and speed up the assignment process. Here we demonstrate how, on a commercially available Q-TWIMS-TOF instrument, we performed top-down ETD of the native form of tetrameric alcohol dehydrogenase. We achieved good sequence coverage throughout the first 81 N-terminal amino acids of ADH, with the exception of a loop located on the inside of the protein. This is in agreement with the exposed parts of the natively folded protein according to the crystal structure. Choosing the right precursor charge state and applying supplemental activation were found to be key to obtaining a high ETD fragmentation efficiency. Finally, we briefly discuss opportunities to further increase the performance of ETD based on our results.
Vibrational properties of self-interstitials in metals (1991)

Abstract The present state of understanding of vibrational properties of self-interstitial atoms (SIAs) in metals is reviewed. The thoery of vibrations of SIAs in metals is discussed. The vibrational behaviour of <100>-dumbbell in fee metals and <110>-dumbbell in bcc metals is treated in detail with the use of Green's function method showing the occurrence of resonance modes and localized modes of SIAs. Changes of various physical properties due to SIAs—the thermodynamic properties including a critical examination of different methods of evaluation of formation entropy, diffuse inelastic scattering of neutrons, dispersion curve, and elastic constants—are discussed. The vibrations of multiple interstitials are also discussed. The vibration of SIAs in hep metals is briefly reviewed. The need for and direction of further work is indicated.
South Africa: Republic of South Africa (1999)

The Dutch first established a trading post at the Cape in 1652. The hinterland was then inhabited by the Khoisan peoples and, further east and north, by Bantu-speaking peoples. There was some white settlement over the next century. During the Napoleonic Wars, Britain took possession of the Cape and later many Boer (Dutch) settlers migrated north-east in the Great Trek. In the mid- 19th century Britain ruled the Cape Colony and Natal along the coast of southern Africa, while in the interior the Afrikaners or Boers, descendants of Dutch settlers, established their own independent republics in the Transvaal and the Orange Free State. Some Bantu African peoples remained unconquered, notably the Xhosas east of the Cape Colony and, north of Natal, the Zulus, whose leader Shaka (died 1828) had formed a powerful kingdom in a great political and demographic upheaval called the Mfecane. The Sothos, who formed another new state under Moshoeshoe, resisted the Boers’ encroachment on their land, until in 1868 Britain granted Moshoeshoe’s request for a protectorate over Basutoland. Meanwhile, British settlers emigrated to Cape Colony and Natal in the 19th century, and from the 1860s many Indians were brought to Natal as indentured labourers on the sugar plantations. The population of the Cape Colony included many Afrikaners as well as the ‘Coloured’ community, descendants of Dutch settlers and indigenous Khoisan women and of Malay slaves. Most coloureds spoke Afrikaans, the offshoot of Dutch spoken by the Boers.
A new approach to dome high tibial osteotomy. (1996)

This article describes a study that evaluates a combined arthroscopy and high tibial osteotomy treatment protocol incorporating: a new curved and double-bladed barrel vault (dome) osteotomy guide; measurement of the mechanical axis of the limb during surgery as well as measurement of the femorotibial angle and mechanical axis before and after surgery; and prior arthroscopic evaluation and debridement. Forty-five high tibial osteotomies were performed in 42 patients. All 45 knees had varus angular deformity. Arthroscopy confirmed osteoarthritis in all 45 knees and grade 4 medial compartment chondromalacia in 44 of 45 knees. Patients were evaluated preoperatively and postoperatively using a grading scale modified from that of the Hospital for Special Surgery. Follow-up of patients ranged from 1 to 6 years (mean: 3.1 years). The average clinical score was 57.4 preoperatively and 89.8 postoperatively, an improvement of 56.4%. All patients achieved and maintained pain relief compared with their preoperative status. No patient needed total knee replacement. These results indicate that in patients with unicompartmental osteoarthritis with angular deformity, high tibial barrel vault (dome) osteotomy can improve the quality of life while preserving the knee joint. There was no relationship between clinical score and either patient age or severity of lateral compartment chondromalacia. Therefore, osteotomy may be appropriate for a larger population than generally thought.
Acoustic signal recovery by thermal demodulation (2006)

One operating mode of recently developed thermoacoustic transducers is as an audio speaker that uses an input superimposed on a direct current; as a result, the audio signal occurs at the same frequency as the input signal. To extend the potential applications of these kinds of sources, the authors propose an alternative driving mode in which a simple thermoacoustic device, consisting of a metal film over a substrate and a heat sink, is excited with a high frequency sinusoid that is amplitude modulated by a lower frequency signal. They show that the modulating signal is recovered in the radiated waves due to a mechanism that is inherent to this type of thermoacoustic process. If the frequency of the carrier is higher than 30kHz and any modulating signal (the one of interest) is in the audio frequency range, only this signal will be heard. Thus, the thermoacoustic device operates as an audio-band, self-demodulating speaker.
A NOTE ON MARIE DE FRANCE'S <i>CHEVREFOIL</i> (1982)

Journal Article A NOTE ON MARIE DE FRANCE'S CHEVREFOIL Get access GLYN S. BURGESS GLYN S. BURGESS Liverpool Search for other works by this author on: Oxford Academic Google Scholar French Studies Bulletin, Volume 2, Issue 3, SUMMER 1982, Pages 1–4, https://doi.org/10.1093/frebul/2.3.1 Published: 01 July 1982
ChemInform Abstract: Crystallization in Space. Implications for Molecular Sieve Synthesis (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sex Differences in Postischemic Neuronal Necrosis in Gerbils (1991)

Twenty-four hour postischemic neuronal necrosis was compared in male vs. female Mongolian gerbils subjected to a 3-h period of severe incomplete hemispheric ischemia produced by unilateral carotid occlusion. The incidence of stroke-prone males was 42.9% versus 26.7% for the females. Among the stroke-prone animals, the males displayed significantly greater neuronal necrosis at 24 h after ischemia compared to the females in the cerebral cortex and CA1 region of the hippocampus. In the CA1 region of the stroke-prone males, only 2.0% of the normal neuronal population remained by 24 h compared to 36.8% in the stroke-prone females (p less than 0.02). In the cerebral cortex, the males had only 19.9% of normal versus 58.2% in the females (p less than 0.05). In a second series of mechanistic experiments, no differences in cortical blood flow (CBF) were disclosed between preselected male and female stroke-prone animals before, during, or for 2 h after ischemia. As with the CBF, the extent of cortical extracellular hypocalcia during ischemia did not differ significantly. However, the degree of postischemic recovery of cortical extracellular calcium was significantly better in the females from 30 min to 2 h after reperfusion. In the same experiments, hemispheric vitamin E levels were measured at the 2 h time point as an index of postischemic brain lipid peroxidation. No difference in baseline vitamin E levels was observed between male and female sham-operated gerbils. In the males subjected to 3 h of ischemia plus 2 h of reperfusion, the hemispheric vitamin E decreased by 43.5% compared to the sham-operated males.(ABSTRACT TRUNCATED AT 250 WORDS)
Experimental and Theoretical Study of a Two Phase Helium High Circulation Loop (2006)

In the framework of the cryogenic cooling system design of the 4T CMS magnet, heat and mass transfer has been experimentally studied at CEA‐Saclay on a 9‐m high helium two‐phase convection loop under atmospheric pressure. The loop includes a 5‐m high heated section surmounted by a 4.5‐m high collector and is connected to the final CMS phase separator. The heated section of the loop is composed of seven aluminum tubes placed in parallel and heated on one side to reproduce the heating configuration of the magnet cooling system. We focused in this paper on the hydraulic characteristics of the two‐phase convection loop. Evolutions of mass flow rate and vapor quality are presented and analyzed as a function of the heat flux with an equations system based on the homogeneous model.
Three Victorians in the New World: interpretations of the New World in the works of Frances Trollope, Charles Dickens, and Anthony Trollope (1992)

A critical examination of the works of three English novelists who visited the United States during the nineteenth century: Frances Trollope, Charles Dickens, and Anthony Trollope. These three produced letters, travel books, and novels, which taken together represent unique commentaries on life during the last century. Utilizing unpublished letters, diaries, and journals of Frances Trollope and Charles Dickens, and collections of letters of Dickens and Anthony Trollope, the study compares their immediate reaction to the scenes and facts of American society with the published travel books, and then with the fictional forms all three subsequently employed in utilizing American scenes or characters.
The Prandtl Wing (2005)

Passenger and cargo traffic are estimated to grow by a factor of two or three in the next two decades, especially along medium and long range routes worldwide. From the end of the 80s, an increasing interest was devoted towards airplanes bigger than B747, due to the traffic growth together with the limited number of available slots and, also, to the competition pressure on the airliner companies. In the document titled “British Airways Requirements for a new large airliner” (Proceeding of the Royal Aeronautical Society, 1992), it was written that “by the term of the century the B747 will be too small when frequency increases are not possible”. At that time, all the questions connected to the so called sustainable growth were not considered. After a decade, the scenario changed. The A380 new large airliner is going to enter into service and a new attention has been devoted to the sustainable growth in Aeronautics by the European Community which, in 2002, defined the advanced concepts for future transport aircraft. The second part of the title of the lecture series (Advanced Concepts for Future Civil Transport Aircraft) is examined first in this paper, in order to define the innovative configuration aircraft which satisfy these concepts.
ChemMine tools: an online service for analyzing and clustering small molecules (2011)

ChemMine Tools is an online service for small molecule data analysis. It provides a web interface to a set of cheminformatics and data mining tools that are useful for various analysis routines performed in chemical genomics and drug discovery. The service also offers programmable access options via the R library ChemmineR. The primary functionalities of ChemMine Tools fall into five major application areas: data visualization, structure comparisons, similarity searching, compound clustering and prediction of chemical properties. First, users can upload compound data sets to the online Compound Workbench. Numerous utilities are provided for compound viewing, structure drawing and format interconversion. Second, pairwise structural similarities among compounds can be quantified. Third, interfaces to ultra-fast structure similarity search algorithms are available to efficiently mine the chemical space in the public domain. These include fingerprint and embedding/indexing algorithms. Fourth, the service includes a Clustering Toolbox that integrates cheminformatic algorithms with data mining utilities to enable systematic structure and activity based analyses of custom compound sets. Fifth, physicochemical property descriptors of custom compound sets can be calculated. These descriptors are important for assessing the bioactivity profile of compounds in silico and quantitative structure-activity relationship (QSAR) analyses. ChemMine Tools is available at: http://chemmine.ucr.edu.
US in Vietnam: Rationale and Law (2017)

A peaceful settlement of the Vietnam War requires some initial conception of a reasonable bargaining position for both sides. In my judgment, the United States has not sufficiently shown that it understands or is prepared to negotiate on such a basis.
Stepwise Reduction of Dinitrogen Bond Order by a Low-Coordinate Iron Complex (2001)

This article discusses stepwise reduction of dinitrogen bond order by a low-coordinate iron complex.
Wide-area overlay networking to manage science DMZ accelerated flows (2014)

There is a new trend emerging across university campuses to deploy Science DMZs (demilitarized zones) to support science drivers that involve for e.g., data-intensive applications needing access to remote instrumentation or public cloud resources. Using advanced technologies such as “multi-domain” software-defined networking, zero-copy RDMA data transfers, active measurements and federated identity/access - accelerated flows are starting to be setup from Science DMZs over wide-area overlay networks, by-passing traditional campus firewalls. In this paper, we present a “campus Science DMZ reference architecture” for adaptively managing host-to-host accelerated flows of multiple researchers over wide-area overlay networks with shared underlay infrastructure components. We discuss our novel approaches in handling challenges of policy specification, security enforcement, and performance engineering within Science DMZs to support diverse accelerated flows on a scalable/extensible basis. Lastly, we present a multi-disciplinary case study of a bioinformatics science driver application in a double-ended campus Science DMZ testbed. Our case study illustrates how our reference architecture can enable new “High-Throughput Computing services” that improve remote accessibility and peer-collaboration of data-intensive science users, and simplify related operations/management for campus network service providers.
Toward Open and Programmable Wireless Network Edge (2016)

Increasingly, the last hop connecting users to their enterprise and home networks is wireless. Wireless is becoming ubiquitous not only in homes and enterprises but in public venues such as coffee shops, hospitals, and airports. However, most of the publicly and privately available wireless networks are proprietary and closed in operation. Also, there is little effort from industries to move forward on a path to greater openness for the requirement of innovation. Therefore, we believe it is the domain of university researchers to enable innovation through openness. In this thesis work, we introduce and defines the importance of open framework in addressing the complexity of the wireless network. The Software Defined Network (SDN) framework has emerged as a popular solution for the data center network. However, the promise of the SDN framework is to make the network open, flexible and programmable. In order to deliver on the promise, SDN must work for all users and across all networks, both wired and wireless. Therefore, we proposed to create new modules and APIs to extend the standard SDN framework all the way to the end-devices (i.e., mobile devices, APs). Thus, we want to provide an extensible and programmable abstraction of the wireless network as part of the current SDN-based solution. In this thesis work, we design and develop a framework, weSDN (wireless extension of SDN), that extends the SDN control capability all the way to the end devices to support client-network interaction capabilities and new services. weSDN enables the control-plane of wireless networks to be extended to mobile devices and allows for top-level decisions to be made from an SDN controller with knowledge of the network as a whole, rather than device centric configurations. In addition, weSDN easily obtains user application information, as well as the ability to monitor and control application flows dynamically. Based on the weSDN framework, we demonstrate new services such as application-aware traffic management, WLAN virtualization, and security management.
Smart Parking and Charging Management of Electric Vehicles in Public Parking Space (2018)

With rapid increase in the number of Electric Vehicles (EVs) hitting the market, there arises a need for an efficient parking and charging management technology for them. The paper presents the design and development of a public smart charging and parking system for EVs by implementing a communication network for EV, Electric Vehicle Supply Equipment(EV-SE) and charging infrastructure (electrical utility). This work involves the development of user space modules, like on-board ECU for battery management (charging, discharging and state of charge estimation) and vehicle to infrastructure (V2I) communication and android application as user interface and infrastructure modules like V2I communication based entry management, navigation management to allotted parking slot, and a centralized server for monitoring, analytics and control. The ECUs are implemented in LPC1768 based mbed microcontroller and communication network implemented using Wi-Fi modem. The proposed system can be implemented in the parking areas of shopping malls, hospitals, schools, colleges, industries or any infrastructure where vehicles will be kept parked for some fixed periods of time.
Intravenous Fluosol in the treatment of acute myocardial infarction. Results of the Thrombolysis and Angioplasty in Myocardial Infarction 9 Trial. TAMI 9 Research Group. (1994)

When given with a thrombolytic agent, Fluosol was not associated with improvement in ventricular systolic function, reduction in thallium infarct size, or overall clinical outcome. Fluosol was, however, associated with a reduction in ischemic complications and with an increase in pulmonary edema and congestive heart failure.
Wireless Sensor Network Designs (2003)

Preface About the Author 1. Networked Embedded Systems 2. Smart Sensor Networks 3. Power-Aware Wireless Sensor Networks 4. Routing in Wireless Sensor Networks 5. Distributed Sensor Networks 6. Clustering Techniques in Wireless Sensor Networks 7. Security Protocols for Wireless Sensor Networks 8. Operating Systems for Embedded Applications 9. Network Support for Embedded Applications 10. Applications of Wireless Sensor Networks References Index
Cellular cofactors affecting hepatitis C virus infection and replication (2007)

Recently identified hepatitis C virus (HCV) isolates that are infectious in cell culture provide a genetic system to evaluate the significance of virus-host interactions for HCV replication. We have completed a systematic RNAi screen wherein siRNAs were designed that target 62 host genes encoding proteins that physically interact with HCV RNA or proteins or belong to cellular pathways thought to modulate HCV infection. This includes 10 host proteins that we identify in this study to bind HCV NS5A. siRNAs that target 26 of these host genes alter infectious HCV production >3-fold. Included in this set of 26 were siRNAs that target Dicer, a principal component of the RNAi silencing pathway. Contrary to the hypothesis that RNAi is an antiviral pathway in mammals, as has been reported for subgenomic HCV replicons, siRNAs that target Dicer inhibited HCV replication. Furthermore, siRNAs that target several other components of the RNAi pathway also inhibit HCV replication. MicroRNA profiling of human liver, human hepatoma Huh-7.5 cells, and Huh-7.5 cells that harbor replicating HCV demonstrated that miR-122 is the predominant microRNA in each environment. miR-122 has been previously implicated in positively regulating the replication of HCV genotype 1 replicons. We find that 2'-O-methyl antisense oligonucleotide depletion of miR-122 also inhibits HCV genotype 2a replication and infectious virus production. Our data define 26 host genes that modulate HCV infection and indicate that the requirement for functional RNAi for HCV replication is dominant over any antiviral activity this pathway may exert against HCV.
Cooperative Regulation of the Cell Division Cycle by the Protein Kinases RAF and AKT (2004)

The RAS-activated RAF-->MEK-->extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3'-kinase (PI3'-kinase)-->PDK1-->AKT signaling pathways are believed to cooperate to promote the proliferation of normal cells and the aberrant proliferation of cancer cells. To explore the mechanisms that underlie such cooperation, we have derived cells harboring conditionally active, steroid hormone-regulated forms of RAF and AKT. These cells permit the assessment of the biological and biochemical effects of activation of these protein kinases either alone or in combination with one another. Under conditions where activation of neither RAF nor AKT alone promoted S-phase progression, coactivation of both kinases elicited a robust proliferative response. Moreover, under conditions where high-level activation of RAF induced G(1) cell cycle arrest, activation of AKT bypassed the arrest and promoted S-phase progression. At the level of the cell cycle machinery, RAF and AKT cooperated to induce cyclin D1 and repress p27(Kip1) expression. Repression of p27(Kip1) was accompanied by a dramatic reduction in KIP1 mRNA and was observed in primary mouse embryo fibroblasts derived from mice either lacking SKP2 or expressing a T187A mutated form of p27(Kip1). Consistent with these observations, pharmacological inhibition of MEK or PI3'-kinase inhibited the effects of activated RAS on the expression of p27(Kip1) in NIH 3T3 fibroblasts and in a panel of bona fide human pancreatic cancer cell lines. Furthermore, we demonstrated that AKT activation led to sustained activation of cyclin/cdk2 complexes that occurred concomitantly with the removal of RAF-induced p21(Cip1) from cyclin E/cdk2 complexes. Cumulatively, these data strongly suggest that the RAF-->MEK-->ERK and PI3'K-->PDK-->AKT signaling pathways can cooperate to promote G(0)-->G(1)-->S-phase cell cycle progression in both normal and cancer cells.
The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina Faso. (2002)

Agricultural use of insecticides is involved in the selection of resistance to these compounds in field populations of mosquitoes in Burkina Faso. Anopheles gambiae s.l. was resistant to permethrin and DDT in cotton-growing and urban areas, but susceptible in areas with limited insecticide selection pressure (rice fields and control areas). Nevertheless, resistance to these insecticides was observed in a village on the outskirts of the rice fields at the end of the rainy season, suggesting that the latter population of mosquitoes had migrated from the surrounding cotton villages into the rice fields. A seasonal variation of resistance observed in the cotton-growing area is related to the distribution of the molecular M and S forms of An. gambiae, since resistance to pyrethroids has so far only been reported in the S form. Pyrethroid resistance in west African An. gambiae was conferred by target site insensitivity through a knockdown resistance (kdr)-like mutation, which was present at high frequencies in mosquitoes in the cotton-growing and urban areas.