gebhart/patrepeval huggingface dataset:
Neural circuit architectures for real-time signal processing in video rate communication systems (2002)

The authors describe the algorithms and hardware used to vector quantize predicted pixel intensity differences for real-time video compression. In this approach, both the algorithms and hardware are derived from aspects of neural network research, which can be thought of as providing new types of heuristics. The hardware is designed for rapid vector quantization performance, which entails the development of application specific associative memory circuits. The real-time associative memory is a key component of the signal processing hardware. Analog hardware is used to perform transform calculations on the source signal intensities, based on a Herault-Jutten network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Improved Adhesion of Gold Thin Films Evaporated on Polymer Resin: Applications for Sensing Surfaces and MEMS (2013)

We present and analyze a method to improve the morphology and mechanical properties of gold thin films for use in optical sensors or other settings where good adhesion of gold to a substrate is of importance and where controlled topography/roughness is key. To improve the adhesion of thermally evaporated gold thin films, we introduce a gold deposition step on SU-8 photoresist prior to UV exposure but after the pre-bake step of SU-8 processing. Shrinkage and distribution of residual stresses, which occur during cross-linking of the SU-8 polymer layer in the post-exposure baking step, are responsible for the higher adhesion of the top gold film to the post-deposition cured SU-8 sublayer. The SU-8 underlayer can also be used to tune the resulting gold film morphology. Our promoter-free protocol is easily integrated with existing sensor microfabrication processes.
Total Synthesis and Biological Evaluation of Siladenoserinol A and its Analogues (2018)

The total synthesis of siladenoserinol A, an inhibitor of the p53-Hdm2 interaction, has been achieved. AuCl<sub>3</sub> -catalyzed hydroalkoxylation of an alkynoate derivative smoothly and regioselectively proceeded to afford a bicycloketal in excellent yield. A glycerophosphocholine moiety was successfully introduced through the Horner-Wadsworth-Emmons reaction using an originally developed phosphonoacetate derivative. Finally, removal of the acid-labile protecting groups, followed by regioselective sulfamate formation of the serinol moiety afforded the desired siladenoserinol A, and benzoyl and desulfamated analogues were also successfully synthesized. Biological evaluation showed that the sulfamate is essential for biological activity, and modification of the acyl group on the bicycloketal can improve the inhibitory activity against the p53-Hdm2 interaction.
Polymer immobilised TEMPO (PIPO): an efficient catalyst for the chlorinated hydrocarbon solvent-free and bromide-free oxidation of alcohols with hypochlorite (2000)

PIPO, a readily prepared polymer immobilised TEMPO, can be employed as an efficient recyclable heterogeneous catalyst for the chlorinated hydrocarbon solvent-free and bromide-free bleach oxidation of a variety of alcohols and polyols.
lac Repressor blocks transcribing RNA polymerase and terminates transcription. (1986)

Operator sequences are essential elements in many negatively controlled operons. By binding repressors, they prevent the formation of active complexes between RNA polymerase and promoters. Here we show that the Escherichia coli lac operator-repressor complex also efficiently interrupts ongoing transcription. This observation suggests a mechanism of action for operators located distal to promoter sequences.
Finding and Indexing of Eccentric Events in Video Emanates (2010)

International audience
Integral Skin Urethane Foam (1968)

<div class="htmlview paragraph">A new process for preparing urethane foam automotive trim parts is described. The new system known as integral skin foam, forms its own continuous skin which reproduces exactly the surface of the mold. Rapid mold turnover, room temperature cure, and the elimination of plastic skin can effect an overall reduction in cost per part.</div> <div class="htmlview paragraph">In items with severe undercuts, the use of pliable, elastomeric molds may be dictated in order to eliminate the juncture lines resulting from a multipart metal mold. The use of liquid urethane elastomer in such areas is described.</div> <div class="htmlview paragraph">The new system requires post-coating, and nondiscoloring urethane types for exterior as well as interior parts are also discussed.</div>
G protein multiplicity in eukaryotic signal transduction systems (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTG protein multiplicity in eukaryotic signal transduction systemsMichael A. Lochrie and Melvin I. SimonCite this: Biochemistry 1988, 27, 14, 4957–4965Publication Date (Print):July 12, 1988Publication History Published online1 May 2002Published inissue 12 July 1988https://pubs.acs.org/doi/10.1021/bi00414a001https://doi.org/10.1021/bi00414a001research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations197LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Guided-wave acousto-optic diffraction in AlxGa1−xN epitaxial layers (2004)

The acousto-optic (AO) diffraction of guided optical waves from surface acoustic waves in AlxGa1−xN layers grown on sapphire substrates by Migration Enhanced Metalorganic Chemical Vapor Deposition (MEMGCVD™) technique was studied at the optical wavelengths of 442 and 633nm and acoustic wavelength of 16μm. In the near-to-Bragg diffraction regime, the diffraction efficiency from 90% to 95% was attained at SAW powers of 0.28 and 0.72W for the blue and red light, respectively. The simulation using photo-elastic and electro-optic constants reported in literature revealed the prevailing contribution of the photo-elastic effect to the AO diffraction. The calculated SAW power required to attain the diffraction maximum was about seven times larger than the measured values. This discrepancy implies that the photo-elastic constants of AlN and GaN available from literature are underestimated. The increase in the diffraction efficiency with the decreasing optical wavelength is in a good agreement with the theoretical prediction. This feature makes AlGaN very promising for AO applications in the deep UV region.
Abstract B267: AR-mTOR-1: A potent, selective mTORC 1/2 kinase inhibitor for the treatment of malignancy (2009)

Abstract Through alterations in the PTEN and PI3K genes, the PI3K / Akt pathway is constitutively activated in human cancers. mTOR kinase plays an unique role in this pathway as the key component of two independent signaling complexes (mTORC1 (raptor - rapamycin sensitive) and mTORC2 (rictor - rapamycin insensitive)) that are involved at multiple branch points in this signaling cascade. As such, inhibition of mTOR kinase inactivates both mTOR complexes and therefore serves as an attractive means to target this integral pathway for the treatment of human malignancy. We report the biological and pharmaceutical evaluation of our selective mTOR 1/2 kinase inhibitor AR-mTOR-1. AR-mTOR-1 inhibits mTOR kinase with an IC50 of &lt; 10 nM while maintaining selectivity against PI3K as well as a panel of additional lipid kinases, serine/threonine kinases and cytoplasmic and receptor tyrosine kinases. In mechanistic cellular assays, AR-mTOR-1 inhibits pAkt (Ser473), 4E-BP1 (Thr36/46) and pS6 (Ser235/6) with nanomolar potency, thus demonstrating inhibition of signaling from both mTORC1 and mTORC2 complexes. In line with its enzymatic selectivity over PI3K , AR-mTOR-1 does not significantly inhibit pAkt (Thr308) in cells. AR-mTOR-1 is broadly anti-proliferative in both epithelial and hematologic cancer cell lines, irrespective of mutational status, with IC50's ranging from 30 to 550 nM across 20 cell lines, suggesting the potential for broad clinical activity. Once daily dosing of AR-mTOR-1 in several mouse xenograft models, including PC3 prostate, U87 glioblastma, and H460 lung, results in robust anti-tumor activity. Finally, AR-mTOR-1 possesses desired in vitro and in vivo preclinical ADME properties including low clearance, high permeability and good absorption in three preclinical species. In total these data demonstrate that selectively targeting mTORC1 and mTORC2 with AR-mTOR-1 holds promise for broad spectrum clinical utility as a single agent across a wide array of cancer types. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):B267.
Lipids, lipoproteins, and apoproteins in serum during infection. (1986)

We studied the alterations in the concentrations of total cholesterol, high-density lipoprotein cholesterol, triglycerides, and apoproteins A and B in serum of 54 patients hospitalized for various reasons, who developed sepsis during their stay. Forty of these patients required intensive care, 14 did not. Another group of patients with the same underlying pathological conditions was used as a control. We found the following: Sepsis causes the concentrations of total cholesterol, high-density lipoprotein cholesterol, and apoproteins A and B in serum to decrease, whereas triglycerides increase. However, these changes are not related to the infectious agent, the underlying illness, or the clinical situation of the patients. The return of serum lipids to more normal concentrations parallels the recovery from sepsis. The positive correlation between the drastically decreased concentrations of high-density lipoprotein cholesterol and the severe hypoalbuminemia in these patients suggests a common pathway for these two abnormalities.
MODeRN: multicast on-demand QoS-based routing in wireless networks (2002)

Multicast route computation satisfying specified quality-of-service (QoS) requirements for wireless networks is computationally complex due to the inherent uncertainty in the wireless medium. Multicast route selection which directly corresponds to the Steiner tree computation in graphs also adds to the complexity. Hence designing an on-demand, QoS-based multicast routing scheme is an NP-hard problem. If such routing is statically done beforehand, it does not capture the dynamism of a network. We propose a genetic algorithm (GA) based path (route) computation scheme-multicast on-demand QoS-based routing in wireless networks (MODeRN), which reduces the computational cost. We also study the performance of MODeRN, and compare it with a commonly used path pre-computation method. The results demonstrate that our approach is more efficient.
<i>Graptopetalum paraguayense</i> E. Walther Leaf Extracts Protect Against Brain Injury in Ischemic Rats (2010)

As practice in folk medicine, Graptopetalum paraguayense E. Walther possesses several biological/pharmacological activities including hepatoprotective, anti-oxidant, and anti-inflammatory. We investigated the neuroprotective potential of Graptopetalum paraguayense E. Walther leaf extracts on inflammation-mediated ischemic brain injury. Water (GWE), 50% alcohol (GE50) extracts of Graptopetalum paraguayense E. Walther, and extracts obtained from further extraction of GE50 with ethyl acetate (GEE) were used. Oral administration of GEE, but not GWE or GE50, for 2 weeks protected animals against cerebral ischemia/reperfusion brain injury. The neuroprotective effect of GEE was accompanied by reductions in brain infarction, neurological deficits, caspase-3 activity, malondialdehyde content, microglia activation, and inducible nitric oxide synthase (iNOS) expression. Since microglia-mediated inflammation plays critical roles in ischemic brain injury, anti-inflammatory potential of Graptopetalum paraguayense E. Walther leaf extracts was further investigated on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma-activated BV-2 microglial cells. GEE decreased H(2)O(2)- and LPS/IFN-gamma-induced free radical generation and LPS/IFN-gamma-induced iNOS expression. Mechanistic study revealed that the neuroactive effects of GEE were markedly associated with anti-oxidative potential, activation of serine/threonine and tyrosine phosphatases, and down-regulation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38, Akt, Src, Janus kinase-1, Tyk2, signal transducer and activator of transcription-1, and NF-kappaB and might be attributed to the presence of polyphenolic compounds such as gallic acid, genistin, daidzin, and quercetin. Together, our findings point out its potential therapeutic strategies that target microglia activation, oxidative stress, and iNOS expression to reduce ischemic brain injury and suggest that Graptopetalum paraguayense E. Walther leaf extracts represent a valuable source for the development of neuroprotective agents.
EMI performance of spread spectrum clock signals with respect to the IF bandwidth of the EMC standard (2006)

Spread spectrum clock signals are used in electronic devices to reduce the electromagnetic interference (EMI). In this paper we investigate clock signals with frequency or time interval modulation, by short length sequences of arbitrary waveform. The paper focuses on the viewpoints: 1) analyzing the EMI performance with regard to the IF bandwidth, defined by the EMC standard; and 2) considering application-specific restrictions of clock signal parameters such as frequency range or minimum on and off time. As an application example a DC-DC-converter is treated. The results are compared with modulating sequences generated by chaotic maps.
Linking inflammation and coagulation (2011)

Ischemia and reperfusion are common activators of coagulation that is also accompanied by inflammation. Therefore, targeting this well orchestrated system might be of therapeutic benefit, as its mode of action is dual: clotting inhibition and anti-inflammation. This novel therapeutic approach might at least be of benefit in the treatment of systemic inflammatory syndromes following, that is, cardiovascular surgery.
Milnamide A, an unusual cytotoxic tripeptide from the marine sponge Auletta cf. constricta (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMilnamide A, an unusual cytotoxic tripeptide from the marine sponge Auletta cf. constrictaPhillip Crews, Jarrett J. Farias, Rolf Emrich, and Paul A. KeiferCite this: J. Org. Chem. 1994, 59, 11, 2932–2934Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://doi.org/10.1021/jo00090a008RIGHTS & PERMISSIONSArticle Views288Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (355 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Assessment of back-end RFI mitigation techniques in passive remote sensing (2015)

Radio-Frequency Interference (RFI) is a growing problem specially for those systems that work with low power signals such as passive remote sensing instruments. Consequently, RFI mitigation techniques are currently under development. This works aims at evaluating back-end mitigation algorithms in terms of their probability of detection and mitigation performance. Results show that Wavelet Denoising (WD), and Multiresolution Fourier Transform (MFT) are the best techniques in most scenarios, specially for GNSS-based instruments.
Competitive Translation Efficiency at the Picornavirus Type 1 Internal Ribosome Entry Site Facilitated by Viral<i>cis</i>and<i>trans</i>Factors (2006)

ABSTRACT Enteroviruses (EVs) overcome their host cells by usurping the translation machinery to benefit viral gene expression. This is accomplished through alternative translation initiation in a cap-independent manner at the viral internal ribosomal entry site (IRES). We have investigated the role of cis - and trans -acting viral factors in EV IRES translation in living cells. We observed that considerable portions of the viral genome, including the 5′-proximal open reading frame and the 3′ untranslated region, contribute to stimulation of IRES-mediated translation. With the IRES in proper context, translation via internal initiation in uninfected cells is as efficient as at capped messages with short, unstructured 5′ untranslated regions. IRES function is enhanced in cells infected with the EV coxsackievirus B3, but the related poliovirus has no significant stimulatory activity. This differential is due to the inherent properties of their 2A protease and is not coupled to 2A-mediated proteolytic degradation of the eukaryotic initiation factor 4G. Our results suggest that the efficiency of alternative translation initiation at EV IRESs depends on a properly configured template rather than on targeted alterations of the host cell translation machinery.
InP-HBT optoelectronic integrated circuits for photonic analog-to-digital conversion (2001)

A monolithically integrated optical receiver and a 4-bit flash analog-to-digital converter, all in InP HBT technology, have been implemented. The optical receiver converts an incoming optical pulse train into an electronic signal and is functional up to 10 Gsps. The electronic input 4-bit flash ADC achieves 3.8 effective bits at low input frequency and 2.1 effective bits at Nyquist input frequency when sampled at 10 Gsps. A 4-bit version has 2.8 effective bits at low-input frequency and 2.4 effective bits at Nyquist-input frequency when sampled at 10 Gsps. The 4-bit ADC operates up to 18 Gsps where it has 1.7 effective bits at Nyquist-input frequency.
Combining intratumoral Treg depletion with androgen deprivation therapy (ADT): preclinical activity in the Myc-CaP model (2017)

The immune infiltrate induced by ADT is diverse and varies over time. Therapeutic strategies focusing on depleting Tregs in the peri-castration period are of particular interest.
The influence of microwave frequencies at high temperatures on structural properties of h-BN (2011)

Abstract — The influence of microwave frequencies at high temperature on the structural properties of Boron Nitride (BN) powder had been investigated. Crystallite size, microstrain and the graphitization index (G.I.) were determined before and after the microwave measurements. The x-ray diffraction patterns showed a remarkable increase in both h(002) and h(004) reflections. This means that after the microwaves treatment the preferential orientation factor increased and the powder became more crystallized. This increase in the crystallinity was confirmed by measuring the graphitization index (G.I.), which was found to be decreasing from 1.5 to 1.24, and further established by the small red-shift of the 1363 cm-1 h-BN band in the FTIR spectrum. The SEM micrograph further confirmed this conclusion by showing the grains more closely packed with less porosity. Index Term — Hexagonal Boron Nitride, microwaves, graphitization index, dielectric properties. I.
CNS Repair Requires Both Effector and Regulatory T Cells with Distinct Temporal and Spatial Profiles (2014)

Monocyte-derived macrophages (mo-MΦs) and T cells have been shown to contribute to spinal cord repair. Recently, the remote brain choroid plexus epithelium (CP) was identified as a portal for monocyte recruitment, and its activation for leukocyte trafficking was found to be IFN-γ-dependent. Here, we addressed how the need for effector T cells can be reconciled with the role of inflammation-resolving immune cells in the repair process. Using an acute spinal cord injury model, we show that in mice deficient in IFN-γ-producing T cells, the CP was not activated, and recruitment of inflammation-resolving mo-MΦ to the spinal cord parenchyma was limited. We further demonstrate that mo-MΦ locally regulated recruitment of thymic-derived Foxp3(+) regulatory T (Treg) cells to the injured spinal cord parenchyma at the subacute/chronic phase. Importantly, an ablation protocol that resulted in reduced Tregs at this stage interfered with tissue remodeling, in contrast to Treg transient ablation, restricted to the 4 d period before the injury, which favored repair. The enhanced functional recovery observed following such a controlled decrease of Tregs suggests that reduced systemic immunosuppression at the time of the insult can enhance CNS repair. Overall, our data highlight a dynamic immune cell network needed for repair, acting in discrete compartments and stages, and involving effector and regulatory T cells, interconnected by mo-MΦ. Any of these populations may be detrimental to the repair process if their level or activity become dysregulated. Accordingly, therapeutic interventions must be both temporally and spatially controlled.
The 2015 Fulton Awards : project management construction (2015)

The winners of the prestigious Fulton Awards, which are made every two years by the Concrete Society of Southern Africa(CSSA) to recognise innovation and design excellence in the use of concrete, were announced recently at a gala dinner at the Champagne Sports Resort in the Drakensberg. This article summarises the winners per category, and we hope our readers will enjoy recognising the particular projects they've been involved in.