gebhart/patrepeval huggingface dataset:
Inhibition of Hydroxyapatite Crystal Growth by Substituted Titanocenes (2000)

This paper reports a physicochemical investigation of the effect of titanocenes on hydroxyapatite crystallization in vitro. The experimental conditions resemble the physiological, at sustained supersaturation employing the constant composition method. All titanocene dihalides were found to inhibit crystal growth of hydroxyapatite, possibly through adsorption of the chloride hydrolysis products on the active growth sites. It is suggested that the growth mechanism is probably surface-diffusion-controlled spiral growth. To explain the inhibiting activity of the titanocenes, the relation of the organometallic compound stereochemistry and the crystal surface characteristics is extensively discussed.
Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition (2017)

Abstract Aberrant regulation of BCL-2 family members enables evasion of apoptosis and tumor resistance to chemotherapy. BCL-2 and functionally redundant counterpart, MCL-1, are frequently over-expressed in high-risk diffuse large B-cell lymphoma (DLBCL). While clinical inhibition of BCL-2 has been achieved with the BH3 mimetic venetoclax, anti-tumor efficacy is limited by compensatory induction of MCL-1. Voruciclib, an orally bioavailable clinical stage CDK-selective inhibitor, potently blocks CDK9, the transcriptional regulator of MCL-1. Here, we demonstrate that voruciclib represses MCL-1 protein expression in preclinical models of DLBCL. When combined with venetoclax in vivo , voruciclib leads to model-dependent tumor cell apoptosis and tumor growth inhibition. Strongest responses were observed in two models representing high-risk activated B-cell (ABC) DLBCL, while no response was observed in a third ABC model, and intermediate responses were observed in two models of germinal center B-cell like (GCB) DLBCL. Given the range of responses, we show that CIVO, a multiplexed tumor micro-dosing technology, represents a viable functional precision medicine approach for differentiating responders from non-responders to BCL-2/MCL-1 targeted therapy. These findings suggest that the combination of voruciclib and venetoclax holds promise as a novel, exclusively oral combination therapy for a subset of high-risk DLBCL patients.
The Current Treatment of Pulmonary Hypertension (2009)

The Methodist DeBakey Cardiovascular Journal provides timely updates on important topics in cardiovascular medicine with quarterly, thematic review-article issues. Each issue is curated by subject-matter-expert guest editors and includes invited reviews along with case reports, interesting multimodality images, and humanities submissions. Additional case reports, images, CME quizzes, and editorials are published on a continuous basis online. MDCVJ is geared towards cardiologists, cardiovascular surgeons, general practitioners, and CV residents and fellows and is indexed in PubMed and MEDLINE.MDCVJ is published by Houston Methodist DeBakey Heart & Vascular Center as part of DeBakey CV Education, an epicenter for cardiovascular academic and clinical education programs located in the heart of the Texas Medical Center. Along with the Journal, DeBakey CV Education offers online and hands-on training for cardiovascular healthcare professionals at all stages in their careers. DeBakey CV Education’s vast YouTube library features hundreds of training videos and live webcasts, including Journal features. Subscribe to the YouTube channel today and sign up for newsletter updates about training opportunities.
DGRID: a DHT-based resource indexing and discovery scheme for computational grids (2007)

Traditional DHT (Distributed Hash Tables) abstraction distributes data items among peer nodes on a structured overlay network. This introduces a number of issues when nodes are under different administrative authorities. In this paper, we propose DGRID, a new DHT abstraction for grid resource indexing and discovery where an administrative domain stores only its own data items. This is achieved by having each unique resource type belonging to an administrative domain to join a DHT as a node with a unique identifier. Using Chord as the underlying overlay graph, we show that DGRID lookup path length is at worst comparable with traditional DHT. However, DGRID is by design resilient to node failures without the need to replicate data items.
Analysis and Evaluation of DC-Link Capacitors for High-Power-Density Electric Vehicle Drive Systems (2012)

In electric vehicle (EV) inverter systems, direct-current-link capacitors, which are bulky, heavy, and susceptible to degradation from self heating, can become a critical obstacle to high power density. This paper presents a comprehensive method for the analysis and comparative evaluation of dc-link capacitor applications to minimize the volume, mass, and capacitance. Models of equivalent series resistance that are valid over a range of frequency and operating temperature are derived and experimentally validated. The root-mean-square values and frequency spectra of the capacitor current are analyzed with respect to three modulation strategies and various operating conditions over practical ranges of load power factor and modulation index in EV drive systems. The modeling and analysis also consider the self-heating process and resulting core temperature of the dc-link capacitors, which impacts their lifetimes. Based on an 80-kW permanent-magnet (PM) motor drive system, the application of electrolytic capacitors and film capacitors has been evaluated by both simulation and experimental tests. The inverter power density is improved from 2.99 kW/L to 13.3 kW/L, without sacrificing the system performance in terms of power loss, core temperature, and lifetime.
Merit functions for lithographic lens design (1996)

We describe a new approach to the optimization of lithography lenses where lithographic quality factors are enclosed inside the optimization loop. These quality factors are derived from an image simulation program which calculates the relevant lithography metrics each time an optimization cycle is attempted. We find lithographic merit functions strongly impact the final lens performance, and superior lithographic imaging is possible when they are employed. We also show that lens users benefit by understanding the aberration balance inherent in each lithography lens.
Sterols. LXXXVIII. Pregnanediols from Sarsasapogenin (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSterols. LXXXVIII. Pregnanediols from SarsasapogeninRussell E. Marker and Ewald RohrmannCite this: J. Am. Chem. Soc. 1940, 62, 3, 518–520Publication Date (Print):March 1, 1940Publication History Published online1 May 2002Published inissue 1 March 1940https://pubs.acs.org/doi/10.1021/ja01860a017https://doi.org/10.1021/ja01860a017research-articleACS PublicationsRequest reuse permissionsArticle Views259Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Genetically resistant mice lacking interleukin‐12 are susceptible to infection with <i>Leishmania major</i> and mount a polarized Th2 cell response (1996)

Mice with homologous disruption of the gene coding for either the p35 subunit or the p40 subunit of interleukin-12 (IL-12) and derived from a strain genetically resistant to infection with Leishmania major have been used to study further the role of this cytokine in resistance to infection and the differentiation of functional CD4+ T cell subsets in vivo. Wild-type 129/Sv/Ev mice are resistant to infection with L. major showing only small lesions which resolve spontaneously within a few weeks and develop a type 1 CD4+ T cell response. In contrast, mice lacking bioactive IL-12 (IL-12p35-/- and IL-12p40-/-) developed large, progressing lesions. Whereas resistant mice were able to mount a delayed-type hypersensitivity (DTH) response to Leishmania antigen, susceptible BALB/c mice as well as IL-12-deficient 129/Sv/Ev mice did not show any DTH reaction. To characterize the functional phenotype of CD4+ T cells triggered in infected wild-type mice and IL-12-deficient mice, the expression of mRNA for interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) in purified CD4+ lymph node cells was analyzed. Wild-type 129/Sv/Ev mice showed high levels of mRNA for IFN-gamma and low levels of mRNA for IL-4 which is indicative of a Th1 response. In contrast, IL-12- deficient mice and susceptible BALB/c mice developed a strong Th2 response with high levels of IL-4 mRNA and low levels of IFN-gamma mRNA in CD4+ T cells. Similarly, lymph node cells from infected wild-type 129 mice produced predominantly IFN-gamma in response to stimulation with Leishmania antigen in vitro whereas lymph node cells from IL-12-deficient mice and susceptible BALB/c mice produced preferentially IL-4. Taken together, these results confirm in vivo the importance of IL-12 in induction of Th1 responses and protective immunity against L. major.
The use of nanocrystal quantum dot as fluorophore reporters in molecular beacon-based assays (2016)

The utilization of molecular beacon (MB) biosensor probes to detect nucleic acid targets has received enormous interest within the scientific community. This interest has been stimulated by the operational qualities of MB-based probes with respect to their unique sensitivity and specificity. The design of MB biosensors entails not only optimizing the sequence of the loop to hybridize with the nucleic acid target or optimization of the length of the stem to tune the sensitivity but also the selection of the appropriate fluorophore reporter to generate the signal transduction read-out upon hybridization of the probe with the target sequence. Traditional organic fluorescent dyes are mostly used for signal reporting in MB assays but their optical properties in comparison to semiconductor fluorescent quantum dot (Qdot) nanocrystals are at a disadvantage. This review highlights the progress made in exploiting Qdot as fluorophore reporters in MB-based assays with the aim of instigating further development in the field of Qdot-MB technology. The development reported to date indicates that unparalleled fluorescence signal reporting in MB-based assays can be achieved using well-constructed Qdot fluorophores.
Application of coding and diversity to UHF satellite sound broadcasting systems (1988)

Results are presented of a study of alternative means by which to reduce the required link margins in a satellite sound broadcasting system, thus improving the economic feasibility of the service and increasing the possibility of sharing a radio-frequency allocation with terrestrial services. Propagation models are presented that account for the effects of shadowing and multipath in the operating environments. Comparisons are made of the performance that results using time, frequency, and space diversity to moderate the effects of shadowing and multipath for vehicular and portable receivers. It is shown that space diversity has the broadest applicability in restoring the channel performance that would otherwise be degraded by Rayleigh fading channels and by quasistationary AWGN (additive white Gaussian noise) channels. Example link budgets are given for candidate satellite sound broadcasting system designs that use analog FM and digital modulation techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development (2007)

Members of the Cas family of Src homology 3 (SH3)-domain-containing cytosolic signaling proteins are crucial regulators of actin cytoskeletal dynamics in non-neuronal cells; however, their neuronal functions are poorly understood. Here, we identify a Drosophila Cas (DCas), find that Cas proteins are highly expressed in neurons and show that DCas is required for correct axon guidance during development. Functional analyses reveal that Cas specifies axon guidance by regulating the degree of fasciculation among axons. These guidance defects are similar to those observed in integrin mutants, and genetic analysis shows that integrins function together with Cas to facilitate axonal defasciculation. These results strongly support Cas proteins working together with integrins in vivo to direct axon guidance events.
Quantitative Proteome Analysis Using Differential Stable Isotopic Labeling and Microbore LC−MALDI MS and MS/MS (2005)

We demonstrate an approach for global quantitative analysis of protein mixtures using differential stable isotopic labeling of the enzyme-digested peptides combined with microbore liquid chromatography (LC) matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS). Microbore LC provides higher sample loading, compared to capillary LC, which facilitates the quantification of low abundance proteins in protein mixtures. In this work, microbore LC is combined with MALDI MS via a heated droplet interface. The compatibilities of two global peptide labeling methods (i.e., esterification to carboxylic groups and dimethylation to amine groups of peptides) with this LC-MALDI technique are evaluated. Using a quadrupole-time-of-flight mass spectrometer, MALDI spectra of the peptides in individual sample spots are obtained to determine the abundance ratio among pairs of differential isotopically labeled peptides. MS/MS spectra are subsequently obtained from the peptide pairs showing significant abundance differences to determine the sequences of selected peptides for protein identification. The peptide sequences determined from MS/MS database search are confirmed by using the overlaid fragment ion spectra generated from a pair of differentially labeled peptides. The effectiveness of this microbore LC-MALDI approach is demonstrated in the quantification and identification of peptides from a mixture of standard proteins as well as E. coli whole cell extract of known relative concentrations. It is shown that this approach provides a facile and economical means of comparing relative protein abundances from two proteome samples.
Advanced liquid crystals for television (2004)

This review summarizes the diverse material requirements of the main Liquid Crystal Display (LCD) technologies used for televisions (TVs). We discuss recent advances in liquid crystal materials for this application. We highlight key materials and discuss synthesis, structure–property relations and LC mixture properties. For all technologies we have achieved fast switching LC mixtures (16 ms) and are en route to 8 ms thus improving the switching times for the next generation of superior performance LCD TVs.
Picosecond Chemical and Biological Events (1978)

Picosecond spectroscopy is a relatively new field of science that utilizes ultrashort laser pulses to monitor events taking place in the 10(-12) second regime. The continuing development of picosecond spectroscopy has made possible the detection and measurement of the primary events in many physical and tiological processes. This article describes a currently used picosecond spectroscopy system that is capable of reliably recording picosecond events. Two areas of picosecond research are discussed; one concerns the interaction of electrons in fluids, and the second the primary events in vision.
The clinical significance of sperm-zona pellucida binding (1998)

The development of homologous functional bio-assay for sperm quality assessment has been a focal point of reproductive biologists; in order to provide a scientific based diagnosis in cases of fertilization failure. The availability of oocytes still remains an important limiting factor for laboratories to embark on the methodology of the assay. The use of zonae pellucidae, derived from post mortem and different in vitro fertilization oocytes, enhanced to availability of zonae. Sperm-zona binding has been illustrated to be an essential requisite during human fertilization and can be measured under hemizona assay as well intact zona pellucida conditions. The sensitivity and specificity of sperm-zona binding results indicated the assay to be positively and significantly correlated with in vitro fertilization outcome. Furthermore, a highly significant correlation were illustrated to exist between the normal sperm morphology, hyperactivation, sperm creatine kinase activity and the zona binding capacity of a given sperm sample. It was concluded that andrology testing remains an ever-growing component in the work-up of the infertile couple. We enter the next millennium with many questions that remain to be answered by the hand of efficacious screening techniques and a new formidable therapy in intra cellular sperm injection.
Enhanced Dynamic Cell Selection with Muting Scheme for DL CoMP in LTE-A (2010)

CoMP JP (Coordinated Multi-Point Joint Processing) is regarded as a promising technique to improve both cell edge user throughput and cell average user throughput in LTE-A downlink. CoMP JP can be categorized as CoMP JT (Joint Transmission) and COMP DCS (Dynamic Cell Selection). Compared with CoMP JT schemes, CoMP DCS provides a good trade-off between the transmission algorithm complexity, backhaul overhead and system performance. Conventional DCS scheme can benefit cell edge users by instantaneous selecting the best severed eNB for cell edge users based on limited signaling overhead in uplink radio interface. DCS with muting scheme further apply muting to the strongest neighbor cell for decreasing interference to cell edge users. However the system spectrum efficiency may be degraded, since frequency reuse one is not maintained and radio resource (resource block and power) may not be fully used. An enhanced DCS with muting method is proposed here to further improve the frequency and power efficiency, by using adaptive muting mode selection based on capacity calculation and flexible power allocation based on muting mode selection status. Performance evaluation shows the proposed algorithm can provide about 5.5% cell average throughput gain and about 10% cell edge throughput gain respectively compared with conventional DCS schemes.
Comparison of Three DNA Extraction Methods for Feed Products and Four Amplification Methods for the 5′-Junction Fragment of Roundup Ready Soybean (2012)

Three methods of DNA extraction from feed products and four detection methods for the 5'-junction fragment of genetically modified (GM) Roundup Ready soybean (RRS) were compared and evaluated. The DNA extraction methods, including cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulfate (SDS), and guanidine hydrochloride (Kit), were assessed for their yields and purity of DNA, extraction time, and reagent cost. The DNA yields of CTAB, SDS, and Kit were 52-694, 164-1750 and 23-105 ng/mg sample, and their extraction time was 2.5-3, 2-2.5, and 1.5-2 h with reagent cost about US dollar 0.24, 0.13, and 1.9 per extraction, respectively. The SDS method was generally well suited to all kinds of feed matrices tested. The limits of detection for the four amplification protocols, including loop-mediated isothermal amplification (LAMP), hyperbranched rolling circle amplification (HRCA), conventional polymerase chain reaction (PCR), and real-time PCR, were 48.5, 4.85, 485, and 9 copies of the pTLH10 plasmid, respectively. The ranked results of the four detection methods were based on multiattribute utility theory as follows (from best to worse): HRCA, LAMP, PCR, and real-time PCR. This comparative evaluation was specifically useful for selection of a highly efficient DNA extraction or amplification method for detecting different GM ingredients.
Platelet receptor redox regulation (2008)

Several recent findings point to an important role for redox regulation of platelet responses to collagen involving the receptor, glycoprotein (GP)VI. First, the antioxidant dietary compound, quercetin, was shown to inhibit GPVI-dependent platelet activation and signaling responses to collagen. Second, collagen increased platelet production of the oxygen radical, superoxide anion (O2-), mediated by the multi-subunit enzyme nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) oxidase. In that case, O2- was implicated in regulating not initial aggregation, but collagen-induced thrombus stabilization involving release of ADP. Third, our laboratory showed that an unpaired thiol in the GPVI cytoplasmic tail undergoes rapid oxidation to form GPVI homodimers following ligand binding, preceding GPVI signaling and ectodomain metalloproteolysis, and indicating formation of an oxidative submembranous environment in activated platelets. This review examines receptor/redox regulation in other cells, and relevance to the pathophysiological function of GPVI and other platelet receptors initiating thrombus formation in haemostasis or thrombotic diseases such as heart attack and stroke.
Reactive copolymers of <i>N</i>‐(2‐hydroxypropyl)methacrylamide with <i>N</i>‐methacryloylated derivatives of <scp>L</scp>‐leucine and <scp>L</scp>‐phenylalanine, 1. Preparation, characterization, and reactions with diamines (1977)

Abstract Reactive copolymers of N ‐(2‐hydroxypropyl)methacrylamide ( 1 ) with p ‐nitrophenyl esters of N ‐methacryloylglycyl‐ L ‐leucine ( 3a ), N ‐methacryloylglycyl‐ L ‐phenylalanine ( 3b ), N ‐methacryloyl‐ε‐aminocaproyl‐ L ‐leucine ( 7a ), and N ‐methacryloyl‐ε‐aminocaproyl‐ L ‐phenylalanine ( 7b ) (i.e. copolymers 8–11 ) were synthesized. The polymers thus obtained were characterized by the content of active groups, by intrinsic viscosity [η], and by the rate constant of aminolysis with tert ‐butylamine in dimethyl sulfoxide. Polymers containing free NH 2 groups were prepared by a polymeranalogous reaction with diamines, predominantly 1,6‐hexanediamine. The effect of the copolymer structure, of diamine, and of the reaction conditions on the course of the polymeranalogous reaction was studied.