gebhart/patrepeval huggingface dataset:
Use of machine learning to shorten observation-based screening and diagnosis of autism (2012)

The Autism Diagnostic Observation Schedule-Generic (ADOS) is one of the most widely used instruments for behavioral evaluation of autism spectrum disorders. It is composed of four modules, each tailored for a specific group of individuals based on their language and developmental level. On average, a module takes between 30 and 60 min to deliver. We used a series of machine-learning algorithms to study the complete set of scores from Module 1 of the ADOS available at the Autism Genetic Resource Exchange (AGRE) for 612 individuals with a classification of autism and 15 non-spectrum individuals from both AGRE and the Boston Autism Consortium (AC). Our analysis indicated that 8 of the 29 items contained in Module 1 of the ADOS were sufficient to classify autism with 100% accuracy. We further validated the accuracy of this eight-item classifier against complete sets of scores from two independent sources, a collection of 110 individuals with autism from AC and a collection of 336 individuals with autism from the Simons Foundation. In both cases, our classifier performed with nearly 100% sensitivity, correctly classifying all but two of the individuals from these two resources with a diagnosis of autism, and with 94% specificity on a collection of observed and simulated non-spectrum controls. The classifier contained several elements found in the ADOS algorithm, demonstrating high test validity, and also resulted in a quantitative score that measures classification confidence and extremeness of the phenotype. With incidence rates rising, the ability to classify autism effectively and quickly requires careful design of assessment and diagnostic tools. Given the brevity, accuracy and quantitative nature of the classifier, results from this study may prove valuable in the development of mobile tools for preliminary evaluation and clinical prioritization-in particular those focused on assessment of short home videos of children--that speed the pace of initial evaluation and broaden the reach to a significantly larger percentage of the population at risk.
A comparative evaluation between flat and traditional energy directors for ultrasonic welding of CF/PPS thermoplastic composites (2015)

Energy directors, responsible for local heat generation in ultrasonic welding, are neat resin protrusions traditionally moulded on the surfaces to be welded. This study evaluates an alternative energy directing solution for ultrasonic welding of thermoplastic composites based on the usage of a loose flat layer of neat resin at the welding interface, referred to as ‘flat energy director’. Analysis of dissipated power, displacement of the sonotrode, welding energy and time as well as weld strength compared to more traditional energy directing solutions showed that flat energy directors, which significantly simplify ultrasonic welding of thermoplastic composites, do not have any substantial negative impact in the welding process or the quality of the welded joints.
Endothelial cell protein C receptor plays an important role in protein C activation in vivo (2001)

Endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex about 5-fold in vitro. Augmentation is EPCR concentration dependent even when the EPCR concentration is in excess of the thrombomodulin. EPCR is expressed preferentially on large blood vessel endothelium, raising questions about the importance of protein C-EPCR interaction for augmenting systemic protein C activation. In these studies, this question was addressed directly by infusing thrombin into baboons in the presence or absence of a monoclonal antibody to EPCR that blocks protein C binding. Activated protein C levels were then measured directly by capturing the enzyme on a monoclonal antibody and assaying with chromogenic substrate. Blocking protein C-EPCR interaction resulted in about an 88% decrease in circulating activated protein C levels generated in response to thrombin infusion. Leukocyte changes, fibrinogen consumption, fibrin degradation products, and vital signs were similar between the animals infused with thrombin alone and those infused with thrombin and the anti-EPCR antibody. The results indicate that EPCR plays a major role in protein C activation and suggest that defects in the EPCR gene might contribute to increased risk of thrombosis.
Combined Blockade of IL-17A and IL-17F May Prevent the Development of Experimental Colitis (2013)

The contribution of Th17 cells to the development of colitis is well described. The effector cytokines IL-17A and IL-17F have been proposed as potential therapeutic targets for the treatment of patients with inflammatory bowel disease. In a proof-of-concept study for the treatment of patients with Crohn's disease, secukinumab, a monoclonal antibody directed against IL-17A, was ineffective and associated with more adverse events than placebo. Wedebye Schmidt et al. propose that blockade of both IL-17A and IL-17F, rather than either cytokine alone, attenuates the development of colitis in a T-cell transfer model of experimental colitis. These findings suggest that combined blockade of IL-17A and IL-17F may be an effective strategy for the treatment of patients with inflammatory bowel disease.
Root Zone Temperature, Plant Growth, and Fruit Yield of Tomatillo as Affected by Plastic Film Mulch (2005)

Tomatillo ( Physalis ixocarpa Brot. ex Hornem) is a popular crop in Mexico and other Latin American countries. There is an increasing demand for this vegetable in the United States, particularly from the growing Latino population. However, there is limited information about tomatillo production. The objectives of this study were to determine the effects of plastic mulches on plant growth, yield, and root zone temperature in two cultivars of tomatillo. The study was conducted in Spring and Summer 2000. The design was a randomized complete block with a split plot arrangement, where plastic film mulch (black, gray, and silver mulches, and bare soil) was the main plot and cultivar (`Toma Verde' and `Verde Puebla]) the subplot. In the spring, mulch treatments had little effect on plant growth during the first 30 days after transplanting and there were no significant differences in fruit yields. In the summer planting, both early growth and fruit yields were greatest with the silver and gray mulch treatments and lowest on bare soil. Plant growth during the establishment was related with subsequent plant growth and yield. In mature plants, vegetative top fresh weight and total fruit yield were higher ( P < 0.01) in the spring than in the summer. Total fruit yield (both seasons), marketable yield (spring) and cull yield (spring) were lower in `Toma Verde' than in `Verde Puebla'. Root zone temperatures (RZTs) in the spring (mean = 26.4 °C) were lower than in the summer (mean = 29.3 °C). In both seasons, mean RZT was highest under black mulch and lowest in bare soil. In the summer, plant growth and fruit yields tended to decrease with increasing RZTs. Tomatillo plants grown on mulches with a mean seasonal RZT of 30 °C had fruit yields that were 65% (`Toma Verde') or 50% (`Verde Puebla') lower respectively than those of plants on mulches with a RZT of 27 °C. There were no significant differences in foliar concentrations of N, Ca, Mg, S, B, Zn, Cu and Na among mulches. Foliar concentrations of the majority of mineral nutrients were not related with the mean RZT for the season.
PLC technology of KEPCO (2005)

In this paper, we introduce powerline communication systems in KEPCO is a unique utility and has been leading the Korea PLC technology development. This article provides PLC trial carried out in MV and LV powerline. It contains various information related to system architecture, characteristics of developed devices. Also the future plan is presented.
Robot motion by simultaneously wheel and leg propulsion (2001)

Legged locomotion is effective in extreme ground conditions, but less effective with high speed on flat hard ground where wheeled locomotion is effective. We introduce a way to combine legged and wheeled locomotion (rolking) to gain effective mobility for mobile robot which has to operate in variable conditions including both natural terrain and structured environment. In addition to effective mobility, rolking mode enables possibility to measure the shapes and unevenness of the ground by probing it with the wheel-leg.
Rapid Identification of Fungi by Using the ITS2 Genetic Region and an Automated Fluorescent Capillary Electrophoresis System (1999)

Invasive fungal disease often plays an important role in the morbidity and mortality of immunocompromised patients. The poor sensitivity of current fungal blood culture and histological practices has led to the development of highly sensitive and specific molecular techniques, such as the PCR. Sequence variability of the internal transcribed spacer 2 (ITS2) region of fungi is potentially useful in rapid and accurate diagnosis of clinical fungal isolates. PCR with fungus-specific primers targeted toward conserved sequences of the 5.8S and 28S ribosomal DNA (rDNA) results in amplification of the species-specific ITS2 regions, which are variable in amplicon length. We have made use of the ABI PRISM 310 genetic analyzer and the ABI PRISM 310 GeneScan analysis software for the determination of variable size differences of the ITS2 region of clinically important fungi, including Candida and non-Candida yeasts, Aspergillus species, and a variety of dermatophytes. No cross-reaction occurred when samples were tested against human and bacterial genomic DNA. We have found that most clinically significant fungal isolates can be differentiated by this method, and it therefore serves to be a promising tool for the rapid (<7 h) diagnosis of fungemia and other invasive fungal infections.
Anharmonic effects in light scattering due to optical phonons in silicon (1983)

Systematic measurements by light scattering of the linewidth and frequency shift of the $\stackrel{\ensuremath{\rightarrow}}{\mathrm{q}}=0$ optical phonon in silicon over the temperature range of 5-1400 K are presented. Both the linewidth and frequency shift exhibit a quadratic dependence on temperature at high temperatures. This indicates the necessity of including terms in the phonon proper self-energy corresponding to four-phonon anharmonic processes.
Single-organelle tracking by two-photon conversion (2007)

Spatial and temporal information about intracellular objects and their dynamics within a living cell are essential for dynamic analysis of such objects in cell biology. A specific intracellular object can be discriminated by photoactivatable fluorescent proteins that exhibit pronounced light-induced spectral changes. Here, we report on selective labeling and tracking of a single organelle by using two-photon conversion of a photoconvertible fluorescent protein with near-infrared femtosecond laser pulses. We performed selective labeling of a single mitochondrion in a living tobacco BY-2 cell using two-photon photoconversion of Kaede. Using this technique, we demonstrated that, in plants, the directed movement of individual mitochondria along the cytoskeletons was mediated by actin filaments, whereas microtubules were not required for the movement of mitochondria. This single-organelle labeling technique enabled us to track the dynamics of a single organelle, revealing the mechanisms involved in organelle dynamics. The technique has potential application in direct tracking of selective cellular and intracellular structures.
Rethink the Design of Flash Translation Layers in a Component-Based View (2017)

NAND flash memory is a popular memory device that has many advantages such as high-density, lightweight, shock-resistance, non-volatile, and low-power features. Although NAND flash memory has many attractive features, it still has several limitations due to its architectural characteristics, such as out-of-place update, erase-before-write feature, and limit of erase count. Therefore, various flash translation layers (FTLs) have been proposed to handle the characteristics. An FTL consists of three main functions, such as address translation, garbage collection, and wear-leveling effect. In order to facilitate developers to realize and design the main functions of FTLs, we propose a component-based view to rethink the design of FTLs. With the component-based view, developers can replace inappropriate components to form a new FTL and dynamically replace the present FTL. Therefore, we also propose the transformation of FTLs to adaptively transform a present FTL to a suitable one. In the experiments, we can demonstrate that the revised FTL (by replacing some components) can improve its original performance and the transformed FTL can also improve the performance under the current workload.
Recognition Of Fish Categories Using Deep Learning Technique (2019)

Nowadays the most crucial aspect in Fisheries is the classification and localization of Fish. Due to Segmentation problems, noise and changes in the environmental conditions, it is difficult to classify the images with good accuracy. However, the object recognition with greater accuracy is in great demand. So, in order to solve this problem, the Convolutional Neural Network is used which helps to classify and localize the images with better accuracy. Fish classification is made by training the dataset and the level of accuracy has been improved by using different activation functions. Several comparisons have been made and finally a better method has been identified, thereby the accuracy is improved. Localization helps to generate Region proposals and class labels successfully. Finally, image classification and localization has been made with greater accuracy.
A Backpropagation Neural Network for Computer Network Security (2006)

In this paper, an efficient and scalable technique for computer network security is presented. On one hand, the decryption scheme and the public key creation used in this work are based on a multi-layer neural network that is trained by backpropagation learning algorithm. On the other hand, the encryption scheme and the private key creation process are based on Boolean algebra. This is a new potential source for public key cryptographic schemes which are not based on number theoretic functions and have small time and memory complexities. This paper along with test results show that the possibility of guessing keys is extremely weaker than using the Data Encryption Standard method (DES), which is a widely-used method of data encryption. The presented results are obtained through the use of MATLAB 6.5.1 software.
Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes (1987)

3H-5-Hydroxytryptamine (5-HT) binding sites were analyzed in bovine brain membranes. The addition of either the 5-HT1A-selective drug 8-OH-DPAT (100 nM) or the 5-HT1C-selective drug mesulergine (100 nM) to the assay resulted in a 5-10% decrease in specific 3H-5-HT binding. Scatchard analysis revealed that the simultaneous addition of both drugs decreased the Bmax of 3H-5-HT binding by 10-15% without affecting the KD value (1.8 +/- 0.3 nM). Competition studies using a series of pharmacologic agents revealed that the sites labeled by 3H-5-HT in bovine caudate in the presence of 100 nM 8-OH-DPAT and 100 nM mesulergine appear to be homogeneous. 5-HT1A selective agents such as 8-OH-DPAT, ipsapirone, and buspirone display micromolar affinities for these sites. RU 24969 and (-)pindolol are approximately 2 orders of magnitude less potent at these sites than at 5-HT1B sites which have been identified in rat brain. Agents displaying nanomolar potencies for 5-HT1C sites such as mianserin and mesulergine are 2-3 orders of magnitude less potent at the 3H-5-HT binding sites in bovine caudate. In addition, both 5-HT2- and 5-HT3-selective agents are essentially inactive at these binding sites. These 3H-5-HT sites display nanomolar affinity for 5-carboxyamidotryptamine, 5-methoxytryptamine, metergoline, and 5-HT. Apparent Ki values of 10-100 nM are obtained for d-LSD, RU 24969, methiothepin, tryptamine, methysergide, and yohimbine, whereas I-LSD and corynanthine are significantly less potent. In addition, these 3H-5-HT labeled sites are regulated by guanine nucleotides and calcium. Regional studies indicate that this class of sites is most dense in the basal ganglia but exists in all regions of bovine brain. These data therefore demonstrate the presence of a homogeneous class of 5-HT1 binding sites in bovine caudate that is pharmacologically distinct from previously defined 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2, and 5-HT3 receptor subtypes. We therefore suggest that this class of sites be designated the 5-HT1D subtype of binding sites labeled by 3H-5-HT.
Synthesis and Characterisation of Some Novel Indeno[1,2-c]pyrazoles (2005)

1-(Benzothiazol-2-yl)-4-phenylindeno [1,2-c]pyrazoles (1) and 1-(4-arylthiazol-2-yl)-4-phenylindeno[1,2-c]pyrazoles (2) have been synthesised by the reaction between 1-oxo-3-phenylindan-2-carboxaldehyde (4) and 2-hydrazinobenzothiazoles or 2-hydrazinothiazoles.
The static analysis of Cobol programs (1980)

article Free Access Share on The static analysis of Cobol programs Authors: M. A. Hennell University of Liverpool, Liverpool, U.K. University of Liverpool, Liverpool, U.K.View Profile , W. M. McNicol United Biscuits Ltd., Liverpool, U.K. United Biscuits Ltd., Liverpool, U.K.View Profile , J. Hawkins United Biscuits Ltd., Liverpool, U.K. United Biscuits Ltd., Liverpool, U.K.View Profile Authors Info & Claims ACM SIGSOFT Software Engineering NotesVolume 5Issue 4October 1980 pp 17–25https://doi.org/10.1145/1010884.1010889Online:01 October 1980Publication History 1citation208DownloadsMetricsTotal Citations1Total Downloads208Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
1996-2001 CHI local SIGs column sampler (2001)

No abstract available.
Characterization of Binding Mode for Human Coagulation Factor XI (FXI) Inhibitors (2013)

The human coagulation factor XI (FXI) is a serine protease that plays a significant role in blocking of the blood coagulation cascade as an attractive antithrombotic target. Selective inhibition of FXIa (an activated form of factor XI) disrupts the intrinsic coagulation pathway without affecting the extrinsic pathway or other coagulation factors such as FXa, FIIa, FVIIa. Furthermore, targeting the FXIa might significantly reduce the bleeding side effects and improve the safety index. This paper reports on a docking-based three dimensional quantitative structure activity relationship (3D-QSAR) study of the potent FXIa inhibitors, the chloro-phenyl tetrazole scaffold series, using comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) methods. Due to the characterization of FXIa binding site, we classified the alignment of the known FXIa inhibitors into two groups according to the docked pose: S1-S2-S4 and S1-S1'-S2'. Consequently, highly predictive 3D-QSAR models of our result will provide insight for designing new potent FXIa inhibitors.
In Vitro and in Vivo Analyses of a Phe/Tyr Switch Controlling Product Specificity of Histone Lysine Methyltransferases (2004)

The functional significance of mono-, di-, and tri-methylation of lysine residues within histone proteins is under investigation. Evidence from several model organisms suggests that different methylated states of H3 Lys(9) (H3K9) are generated by specific histone methyltransferases (MTases) to mark distinct types of silent chromatin. Sequence alignment of all histone lysine MTases with known product specificity suggested that a key residue in the active site determines how many methyl groups they add. We examined this possibility both in vitro and in vivo and found that a Phe at the position equivalent to Phe(281) of Neurospora crassa DIM-5 or Phe(1205) of human G9a allows the enzyme to perform di and tri-methylation, whereas a Tyr at this position is restrictive, inhibiting tri-methylation and thus yielding a mono- or di-MTase. Phe to Tyr mutants of both DIM-5 and G9a restrict product specificity in vitro and in vivo without compromising overall catalysis. These mutants were employed to probe the biological significance of mono-, di-, and tri-methylation of H3K9 in both mouse embryonic stem cells and N. crassa. G9a F1205Y, when expressed in G9a (-/-) embryonic stem cells, rescued only H3K9 mono-methylation, but not di-methylation, to wild-type levels yet silenced Mage-a gene expression. When expressed in dim-5 strains, DIM-5 F281Y generated significant levels of mono- and di-H3K9 methylation (which are not observed in wild type Neurospora) as well as tri-methyl H3K9. The altered DIM-5 rescued the growth defect characteristic of dim-5 N. crassa but did not fully rescue the gross DNA hypomethylation of dim-5 strains.
Requirement of B7-mediated costimulation in the induction of experimental autoimmune anterior uveitis. (2001)

The costimulatory signal delivered through CD28-B7 is required for the induction and pathogenesis of EAAU. In the absence of this signal, antigen-specific expansion of MAA reactive T cells as well as production of TNF-alpha is inhibited. Abrogation of this costimulatory signal may be an important therapeutic option for EAAU.
What is Higher Education in Prison? Introduction to Radical Departures: Ruminations on the Purposes of Higher Education in Prison (2018)

For far too long, “correctional education” has served as an umbrella framework for all educational opportunities offered inside prisons and jails throughout the United States. In community with students, scholars, and practitioners, we wish to engage and highlight scholarship on higher education in prison in much the same way we theorize higher education in society more broadly, by focusing on the purposes for why we should engage this work. The authors in this volume pose a direct challenge to the notion that higher education on non-carceral campuses and higher education in prisons should be guided by significantly different philosophies of higher education and in this Introduction, we outline the philosophies of education that should guide higher education in prison.
Particle−Rod Hybrids:  Growth of Arachidic Acid Molecular Rods from Capped Cadmium Selenide Nanoparticles (2004)

This communication describes a spin-coating method to nucleate organic molecular rods of uniform size from an inorganic nanoparticle at a solid surface. The particle-rod hybrid structure spontaneously forms when a film is spin coated from a mixed 2-propanol solution of arachidic acid (AA) and nanoparticles of cadmium selenide capped by mercaptoundecanoic acid (MUA-CdSe) on graphite. AFM images show that MUA-CdSe nanoparticles nucleate single crystalline rods of AA with a cross section of a single unit cell of the C-form. The solution-based process potentially allows the precise tuning of the wetting profile of the solution on the surface-attached nanoparticle, which provides the reservoir for the growth of the single crystalline rods. The results suggest that nanoparticles can be regarded as nanoseeds for the nucleation of guest crystals. It should be possible to further functionalize the AA rods by electrostatic complexation with metal or organic ions.