gebhart/patrepeval huggingface dataset:
Effect of an implant of trenbolone acetate and estradiol on growth, feed efficiency, and carcass composition of Holstein and beef steers1 (1991)

The effects of an implant of 140 mg of trenbolone acetate and 28 mg of estradiol (TBA + E2) on performance and carcass composition were evaluated with 72 individually fed steers. Holstein (n = 24), Angus (n = 24), and Angus x Simmental (n = 24) steer calves were allocated by breed and implant treatment to either an individual feeding pen (n = 36) or an electronic feeding door in a group pen (three pens with 12 animals per pen). Intake and refusal of the 85% concentrate diet were recorded daily. Animals were slaughtered when ultrasonic attenuation values of the longissimus muscle at the 12th rib reached .55, which is correlated with low Choice marbling. At slaughter, complete carcass measurements were taken and the right side of each carcass was separated into boneless wholesale cuts. Implanting with TBA + E2 improved (P less than .01) daily gain and feed efficiency. Daily gain was increased 17, 26, and 21% in Holstein, Angus, and crossbred steers, respectively. The implant increased overall daily protein and fat accretion 23%. Carcass conformation and dressing percentage were not affected (P greater than .05) by TBA + E2 treatment. Implantation with TBA + E2 had little effect on yield of wholesale boneless cuts when expressed as a percentage of carcass weight but increased absolute weight as a small degree of marbling by 6 to 40 kg.
Molecular detection and typing of human papillomavirus in laryngeal carcinoma specimens (2005)

Ten of the 31 samples (32%) were positive for HPV DNA and all of the samples were positive for human beta-globin. The genotypes identified were HPV 16 (n=3), HPV 58 (n=2) and HPV 39, 45, 51, 59, 66 and 69 (n=1 for each). The three samples positive for HPV 16 had lost region E2, meaning that the viral DNA had been integrated into the host genome.
TC-motifs at the TATA-box expected position in plant genes: a novel class of motifs involved in the transcription regulation (2010)

Our observations suggest that the TC-elements might constitute a class of novel regulatory elements participating towards the complex modulation of gene expression in plants.
Energy and Volume Relations in the Solubilities of Some Ketones in Water. (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnergy and Volume Relations in the Solubilities of Some Ketones in Water.Paul. Gross, Joseph C. Rintelen, and John H. SaylorCite this: J. Phys. Chem. 1939, 43, 2, 197–205Publication Date (Print):February 1, 1939Publication History Published online1 May 2002Published inissue 1 February 1939https://doi.org/10.1021/j150389a002RIGHTS & PERMISSIONSArticle Views56Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (437 KB) Get e-Alerts
What does the future hold for top down mass spectrometry? (2009)

Mass spectrometry (MS) research has revolutionized modern biological and biomedical fields. At the heart of the majority of mass spectrometry experiments is the use of Bottom Up mass spectrometry methods where proteins are first proteolyzed into smaller fragments before MS interrogation. The advent of electron capture dissociation and, more recently, electron-transfer dissociation, however, has allowed Top Down (analysis of intact proteins) or middle down (analysis of large polypeptides) mass spectrometry to both experience large increases in development, growth, and overall usage. Nevertheless, for high-throughput large-scale proteomic studies, Bottom Up mass spectrometry has easily dominated the field. As Top Down mass spectrometry methodology and technology continue to develop, will it genuinely be able to compete with Bottom Up mass spectrometry for whole proteome analysis? Discussed here are the current approaches, applications, issues, and future view of high-throughput Top Down mass spectrometry.
ADIPOSE-DERIVED STEM CELLS FOR THE TREATMENT OF DIABETIC ERECTILE DYSFUNCTION IN THE ZDF TYPE-II DIABETIC FATTY RAT (2009)

You have accessJournal of Urology1 Apr 2009ADIPOSE-DERIVED STEM CELLS FOR THE TREATMENT OF DIABETIC ERECTILE DYSFUNCTION IN THE ZDF TYPE-II DIABETIC FATTY RAT Maurice M Garcia, Alan W Shindel, Thomas M Fandel, Guiting Lin, Benjamin N Breyer, and Tom F. Lue Maurice M GarciaMaurice M Garcia More articles by this author , Alan W ShindelAlan W Shindel More articles by this author , Thomas M FandelThomas M Fandel More articles by this author , Guiting LinGuiting Lin More articles by this author , Benjamin N BreyerBenjamin N Breyer More articles by this author , and Tom F. LueTom F. Lue More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60137-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "ADIPOSE-DERIVED STEM CELLS FOR THE TREATMENT OF DIABETIC ERECTILE DYSFUNCTION IN THE ZDF TYPE-II DIABETIC FATTY RAT." The Journal of Urology, 181(4S), p. 44 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 44 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Maurice M Garcia More articles by this author Alan W Shindel More articles by this author Thomas M Fandel More articles by this author Guiting Lin More articles by this author Benjamin N Breyer More articles by this author Tom F. Lue More articles by this author Expand All Advertisement PDF downloadLoading ...
Compilation and prevalence of mutations associated with resistance to non-nucleoside reverse transcriptase inhibitors (2009)

The list of 44 NNRTI RAMs compiled in this study provides a comprehensive overview of mutations that play a role in HIV-1 NNRTI resistance and can be used to guide further in vitro and in vivo research on the mechanisms of HIV-1 NNRTI resistance.
Using postordering and static symbolic factorization for parallel sparse LU (2002)

In this paper we present several improvements of widely used parallel LU factorization methods on sparse matrices. First we introduce the LU elimination forest and then we characterize the L, U factors in terms of their corresponding LU elimination forest. This characterization can be used as a compact storage scheme of the matrix as well as of the task dependence graph. To improve the use of BLAS in the numerical factorization, we perform a postorder traversal of the LU elimination forest, thus obtaining larger supernodes. To expose more task parallelism for a sparse matrix, we build a more accurate task dependence graph that includes only the least necessary dependences. Experiments compared favorably our methods against methods implemented in the S* environment on the SGI's Origin2000 multiprocessor.
Mechanical and Physical Properties of Recombinant Spider Silk Films Using Organic and Aqueous Solvents (2014)

Spider silk has exceptional mechanical and biocompatibility properties. The goal of this study was optimization of the mechanical properties of synthetic spider silk thin films made from synthetic forms of MaSp1 and MaSp2, which compose the dragline silk of Nephila clavipes. We increased the mechanical stress of MaSp1 and 2 films solubilized in both HFIP and water by adding glutaraldehyde and then stretching them in an alcohol based stretch bath. This resulted in stresses as high as 206 MPa and elongations up to 35%, which is 4× higher than the as-poured controls. Films were analyzed using NMR, XRD, and Raman, which showed that the secondary structure after solubilization and film formation in as-poured films is mainly a helical conformation. After the post-pour stretch in a methanol/water bath, the MaSp proteins in both the HFIP and water-based films formed aligned β-sheets similar to those in spider silk fibers.
Soft Plasmonic Assemblies Exhibiting Unnaturally High Refractive Index (2020)

The increases in refractive indices (<i>n</i>) of materials are crucial for transformative optical technologies. With the progress of monolithic lithography, large advances have been achieved with several semiconductors, including silicon, germanium, and gallium arsenide, which generally provide higher <i>n</i> of ∼4.0 compared to those of other elements. Nevertheless, above this upper limit of naturally available <i>n</i>, the range of light-matter interactions could be unprecedentedly expanded, which in turn enriches the possible applications. Here, we present a soft self-assembly of polyhedral Au colloids as a promising method to achieve unnaturally high <i>n</i> values. The interfacial assembly of Au nanocubes provides <i>n</i> of 6.4 at the resonant wavelength (near-infrared) and 4.5 in the off-resonant regimes (mid-infrared), which have not been previously reached. The soft self-assembly of polyhedral Au colloids can be a versatile and highly effective route for the fabrication of optical metamaterials with unnaturally high <i>n</i> values.
Prototype waveform optimization for an OFDM/OQAM system with hexagonal time-frequency lattice structure (2007)

This paper deals with the optimization of the time-frequency localization of the prototype waveform for OFDM/OQAM with hexagonal time-frequency lattice. The set of orthonormal waveforms among which the optimally localized one should be searched are obtained as the orthonormalization of mother functions well localized in time-frequency. To preserve as much as possible the good localization of the original mother functions, the canonical form of the orthonormalization procedure is used. For an easy and systematic way to generate well localized mother functions, we use the orthonormal base of Hermite functions, which are known to provide, in decreasing order, the best time-frequency localization. To preserve the pi/3 rotational invariance of the hexagonal lattice in the ambiguity function of each candidate prototype function, only Hermite functions with indices multiple of 6 are allowed. The obtained numerical results show that the optimized prototype waveform outperforms in localization the best localized waveform for OFDM/OQAM with square time-frequency lattice.
Tegaserod, a 5‐HT<sub>4</sub> receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation (2001)

Based upon the results of this study, tegaserod offers rapid and sustained relief of the abdominal pain and constipation associated with irritable bowel syndrome. Tegaserod is also well tolerated.
In vivo evaluation of a novel alginate dressing (1999)

Alginate dressings are currently used in the management of epidermal and dermal wounds, and provide a moist environment that leads to rapid granulation and reepithelialization. However, a cytotoxic effect on proliferation of fibroblasts and residual material with inflammation in healing wounds have been reported recently. We have developed a new alginate dressing (AGA-100), which does not have an inhibitory effect on proliferation of fibroblasts. The purpose of this study was to evaluate the new alginate dressing with respect to wound healing in full- and partial-thickness pig wounds and with respect to biodegradation following implantation into rabbit muscle. Kaltostat and Sorbsan, both well-established commercial dressings, were used as control. The closure rate of full-thickness wounds treated with AGA-100 was significantly higher on day 15 compared with that with Kaltostat and Sorbsan. Reepithelialization rate of partial-thickness wounds treated with Sorbsan was statistically significantly lower on day 3 than those with the other two dressings. As to dressing debris remained in the healing wound, a large amount of foreign debris was noted in all the full-thickness wounds treated with Kaltostat or Sorbsan, while only about one-third of wounds treated with AGA-100 showed a little dressing debris. AGA-100 implanted into the muscle of rabbits was bioresorbed completely within 3 months. Therefore, dressing residue in AGA-100-treated full-thickness wounds might be fully absorbed in a few months. In conclusion, it is shown that our newly developed AGA-100 possesses superior properties compared with typical alginate dressings.
Powerful Two-Sample Tests Based on the Likelihood Ratio (2006)

AbstractA new approach to constructing nonparametric tests for the general two-sample problem is proposed. This approach not only generates traditional tests (including the two-sample Kolmogorov–Smirnov, Cramér–von Mises, and Anderson–Darling tests), but also produces new powerful tests based on the likelihood ratio. Although conventional two-sample tests are sensitive to the difference in location, most of them lack power to detect changes in scale and shape. The new tests are location-, scale-, and shape-sensitive, so they are robust against variation in distribution.KEY WORDS : Anderson–Darling testCramér–von Mises testKolmogorov–Smirnov testLocationPower comparisonScaleShape
Next-generation sequencing of FFPE solid tumor specimens for clinical use. (2012)

10524 Background: As more therapies targeting genomic alterations become available, genotyping (e.g., by Sequenom) is increasingly performed in tumor types where mutational status may drive treatment choice. Next-generation sequencing (NGS) technology can expand on genotyping of individual base pairs because it can detect mutations across entire exons, copy changes and fusion genes. However, for NGS to be clinically viable, it must be made compatible with FFPE tissues and shown concordant with best current diagnostic methods. Methods: To explore a potential clinical role for NGS, we selected 120 FFPE specimens (68 NSCLC, 32 CRC, 20 melanoma) previously tested for 97 oncogenic mutations in 8 oncogenes by Sequenom, and sequenced all exons of 182 cancer genes. Genotyping and sequencing were both performed in CLIA compliant labs. DNA was extracted from 4x 10μ unstained sections from the diagnostic FFPE block, followed by library construction and hybridization capture of 3230 exons and 37 commonly rearranged introns. Average coverage of >900X uniquely-mapping reads was obtained. Sequence data were analyzed for all genomic alterations and examined for potentially actionable mutations. Results: High concordance was noted between Sequenom and NGS: 103 and 105 mutations were called by the two technologies, respectively, at mutually tested sites, with 97 mutation calls in common. Notably, mutant allele frequencies in concordant calls ranged as low as 2% by NGS, highlighting the sensitivity of detection enabled by both approaches. Furthermore, in 45/120 (38%) specimens, NGS revealed additional alterations that may confer sensitivity or resistance to approved or experimental targeted therapies and thus plausibly influence treatment decisions. These included 39 copy changes or loss-of-function variants best assayed by an NGS approach. Conclusions: Our results demonstrate technical feasibility and highlight potential benefits of comprehensive cancer gene characterization through next-generation sequencing of clinical FFPE specimens. As NGS is the most practical means to detect all classes of somatic alteration in a small, clinically relevant sample, we suggest that this type of testing will become an essential component of patient care.
Substitutent Effects in the Periphery of 2,9-Bisaryl-tetraazaperopyrene Dyes (2010)

A series of 2,9-bisaryl-1,3,8,10-tetraazaperopyrene (TAPP) derivatives has been synthesized by reacting 4,9-diamino-3,10-perylenequinone diimine with a large excess of the corresponding benzoyl chloride in refluxing nitrobenzene. Among all derivatives only ortho-substituted phenyl congeners were sufficiently soluble for studying solutions of defined concentration in organic solvents. The molecular structures of the crystallized compounds, determined by X-ray diffraction of four derivatives, are determined by the planar tetraazaperopyrene core and the interplanar angle of the phenyl rings, which depends on the size of the ortho substituent (40-70°). The intermolecular packing pattern of all compounds is characterized by parallel stacks of molecules with the substituted phenyl rings rotated out of the peropyrene plane to reduce the steric repulsion. Crystals of a TAPP derivative suitable for X-ray diffraction were grown from trifluoroacetic acid (TFA) for the first time, establishing a 2-fold protonated species. The ground-state geometries of the TAPP derivatives were calculated by DFT [B3PW91/6-31g(d,p)] and the lowest unoccupied molecular orbital (LUMO) energies of derivatives possessing electron-withdrawing groups were decreased, as were the computed electron affinities. The results of the modeling study were confirmed experimentally by cyclic voltammetry to evaluate the substituent effects on the highest occupied molecular orbital (HOMO) and the LUMO of the peropyrene core. The UV-vis absorption spectra of all compounds recorded in trifluoroacetic acid are almost superimposable and display a characteristic visible absorption band between 460 and 490 nm (log ε = 4.64-5.01) with a strong vibrational progression of 1173-1475 cm(-1). Their fluorescence spectra are characterized by bands between 490 and 530 nm that are the mirror images of the absorption spectra (Stokes shifts of 10-50 nm). The luminescence quantum yields range from <0.01 to 0.30, thereby indicating a quenching effect for some substitution patterns.
Head impact conditions in the case of cyclist falls (2012)

In 2009 approximately half of the French population owned a bicycle. However, the cyclist’s accident rate is the highest of all road users. Hence, it is necessary to set up a protection system for cyclists, especially for the cephalic segment. Currently, relatively little literature has dealt with the head impact condition for this kind of accident, especially for cases of cyclist falls. Therefore, the objective of this work was to identify the initial conditions for head impact in cases of cycling fall accidents. The present paper proposes a parametric study by simulating a lot of accident scenarios. A total of 1024 simulations have been automatically carried out using Madymo ® ’s software and a specially designed program. Two situations of cycling falls have been investigated according to real accident configuration: cyclist falls due to skidding and after hitting a curb. The TNO (Dutch Organization for Applied Scientific Research, Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek) pedestrian 50th percentile human model was coupled to a city bicycle model. The analysed outputs are head impact area and head velocity before impact. The work has provided a solid information base for future work on cyclist accidents. The parametric analysis was also used to study the effects of poorly known environmental parameters, such as speed or torso inclination. The results provided estimates of the impact area and speed of the head, which helps to improve the design of safer helmets and of helmet certification standards tests.
Remaking Speech (1939)

Speech has been remade automatically from a buzzer-like tone and a hiss-like noise corresponding to the cord-tone and the breath-tone of normal speech. Control of pitch and spectrum obtained from a talker's speech are applied to make the synthetic speech copy the original speech sufficiently for good intelligibility although the currents used in such controls contain only low syllabic frequencies of the order of 10 cycles per second as contrasted with frequencies of 100 to 3000 cycles in the remade speech. The isolation of these speech-defining signals of pitch and spectrum makes it possible to reconstruct the speech to a wide variety of specifications. Striking demonstrations upon altering the pitch of the remade speech stress the contribution of the pitch to the emotional content of speech. Similarly the spectrum is shown to contribute most of the intelligibility to the speech.
Rapid detection in spinal fluid of beta-lactamase produced by ampicillin-resistant Haemophilus influenzae (1982)

The chromogenic cephalosporin nitrocefin was used to detect the presence of beta-lactamase in cerebrospinal fluid of patients suffering from ampicillin-resistant Haemophilus influenzae meningitis. Five samples of spinal fluid containing ampicillin-resistant isolates were studied, and all had beta-lactamase activity. When samples of spinal fluid containing 33 ampicillin-sensitive isolates and 234 sterile specimens were tested, no beta-lactamase activity was detected.
Two-layer Predictive Controller for V2G and G2V Services Using on Wireless Power Transfer Technology (2018)

This paper presents a comprehensive solution that allows electric vehicles (EV) to autonomously charge and discharge their batteries wirelessly during long term parking and/or the transient stops. A two-layer power-flow controller for bidirectional wireless power transfer system (BWPTS) in EVs applications is proposed. The proposed controller can manage the bidirectional power-flow between EV and surrounding infrastructures such as power grid, home microgrid, building micro-grid, road or another vehicle. It consists of two levels of control; the first is responsible for communicating with the surrounding infrastructures and gathering information from driver, charging station, power grid and battery management system and then, based on these information, it estimates the EV's psychological price as a function of its battery's state-of-charge (SOC) and compares it with the energy price to decide whether to charge, discharge or abstain, and how much the charging or discharging rate. The second layer receives the reference signal from the first one and generates the control parameters for two synchronized resonant converters (one is on the vehicle side and the other is on the grid side) to provide the requited power-flow. The proposed controller is adaptively estimating the system parameters to consider the misalignment conditions effects on the system performance. The parameter estimation is achieved using only one voltage sensor. The second layer control is designed based on a new analytical modeling for the power flow in the system. For verification purposes, a prototype for BWPTS was built and driven by the proposed controller, which was implemented using a field-programmable gate array (FPGA) integrated circuit. The proposed controller provides very fast and stable response during both the transient and steady state operation in comparison with the conventional PI controller.