gebhart/patrepeval huggingface dataset:
Mechanisms of Ligand Recognition in Myoglobin (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanisms of Ligand Recognition in MyoglobinBarry A. Springer, Stephen G. Sligar, John S. Olson, and George N. Jr. PhillipsCite this: Chem. Rev. 1994, 94, 3, 699–714Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/cr00027a007https://doi.org/10.1021/cr00027a007research-articleACS PublicationsRequest reuse permissionsArticle Views2399Altmetric-Citations689LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Information Security Management Handbook, Volume 3 (2006)

Since 1993, the Information Security Management Handbook has served not only as an everyday reference for information security practitioners but also as an important document for conducting the intense review necessary to prepare for the Certified Information System Security Professional (CISSP) examination. Now completely revised and updated and i
Distributed feedback lasers with multiple phase-shift regions (1988)

Phase-shifted distributed-feedback (PSDFB) lasers with multiple phase-shift regions are proposed to reduce the effect of spatial hole burning in conventional PSDFB lasers where a single phase shift leads to a highly nonuniform axial distribution of the mode intensity. We analyze multiple phase-shift PSDFB lasers by solving numerically the coupled-wave equations. Our results show that the use of even two phase-shift regions can substantially reduce the axial inhomogeneity of the mode intensity. Although the gain margin is generally reduced by the use of multiple phase shifts, it is still large enough for most practical purposes if the phase shifts are suitably optimized.
Stabilizing an amorphous V<sub>2</sub>O<sub>5</sub>/carbon nanotube paper electrode with conformal TiO<sub>2</sub> coating by atomic layer deposition for lithium ion batteries (2015)

Amorphous V<sub>2</sub>O<sub>5</sub> (a-V<sub>2</sub>O<sub>5</sub>) thin films were conformally coated onto the surface of hydroxyl (–OH) functionalized multi-walled carbon nanotubes (CNTs) and carbon nanotube (CNT) paper using atomic layer deposition (ALD).
Identification and Characterization of T-Cell Epitopes Deduced from <i>RGS5</i>, a Novel Broadly Expressed Tumor Antigen (2007)

These results indicate that the RGS5 peptides represent interesting candidates for the development of cancer vaccines designed to target malignant cells and tumor vessels.
SSI: characteristics of persons receiving federally administered State supplementation only. (1983)

This article summarizes the demographic and economic characteristics of the half million persons on the rolls of the Supplemental Security Income (SSI) program in January 1981 whose only payment was a federally administered State supplement. All of these persons were ineligible for a Federal SSI payment because their countable income from other sources exceeded $258 (the Federal benefit rate plus the $20 Federal income disregard). The data indicate that 62 percent of these persons resided in California; nearly 75 percent were aged 65 or older; 81 percent were white; and 65 percent were women. Almost all of these persons received a monthly Social Security benefit, which averaged $286. The average monthly State supplementary payment for the members of this group was $84.
Why target apoptosis in cancer treatment? (2003)

Defective apoptosis (programmed cell death) represents a major causative factor in the development and progression of cancer. The ability of tumor cells to evade engagement of apoptosis can play a significant role in their resistance to conventional therapeutic regimens. Our understanding of the complexities of apoptosis and the mechanisms evolved by tumor cells to resist engagement of cell death has focused research effort into the development of strategies designed to selectively induce apoptosis in cancer cells. This article will review the underlying mechanisms of apoptosis and the ways in which tumor cells modulate these processes to promote their survival and evaluate the efficacy of current clinical approaches aimed at exploiting these defects to selectively induce apoptosis in tumor cells.
Chiral Scandium‐Catalysed Enantioselective Ring‐Opening of <i>meso</i>‐Epoxides with N‐Heterocycle, Alcohol and Thiol Derivatives in Water (2006)

Abstract In the presence of catalytic amounts of Sc(OSO 3 C 12 H 25 ) 3 and a chiral bipyridine ligand, asymmetric ring‐opening of meso ‐epoxides with aromatic N‐heterocycles, an alcohol and thiols proceeded smoothly to afford the corresponding products in moderate to good yields (34–85 %) with high to excellent enantioselectivities (74–96 % ee ). Water was used as the sole and essential solvent in these important enantioselective transformations.
Over the counter H <sub>2</sub> receptor antagonists (1994)

Improvements in living standards, particularly arising from more disposable income * Environmental improvements-for example, housing, roads * Reduction in tobacco consumption * Improvements in education and communication * Better, more effective, and easier access to health services Futuret * High standards of living and lower unemployment rates * Decline of tobacco consumption * Better health services delivering more effective treatments * Education, to include change in behaviour to reduce risk factors
Molecular Characterization and Identification of <i>Bacillus clausii</i> Strains Marketed for Use in Oral Bacteriotherapy (2001)

A substantial number of Bacillus species have been marketed for use in oral bacteriotherapy because of their purported ability to prevent or treat various gastrointestinal disorders. Recently, some of the Bacillus strains in Enterogermina, which is made up of aqueous suspensions of viable Bacillus spores, have been partially characterized and aligned with members of the Bacillus alcalophilus subgroup rather than with Bacillus subtilis, as previously reported. With a view toward verifying the original taxonomic position of the Enterogermina strains, we catalogued both phenotypic and genotypic traits exhibited by the four Bacillus strains isolated from the spore mixtures found in original commercial preparations dated 1975 and 1984 and commercial preparations now being propagated industrially. Analyses of physiological and biochemical traits, complete 16S rRNA gene sequences, DNA-DNA reassociation, tRNA intergenic spacer length polymorphism, single-strand conformation polymorphism of PCR-amplified spacer regions of tRNA genes, and randomly amplified polymorphic DNA led to the finding that all of the Enterogermina strains belong to a unique genospecies, which is unequivocally identified as the alkalitolerant species Bacillus clausii. Moreover, we provide evidence that in contrast to several reference strains of B. clausii, the strains constituting Enterogermina are characterized by a notable low level of intraspecific genome diversity and that each strain has remained the same for the last 25 years.
Heat shock. A new approach for myocardial preservation in cardiac surgery. (1992)

The results show that preconditioning the heart with HS improves postischemic ventricular performance and attenuates cellular injury. HS induces a change in cellular metabolism, prompting the expression of HSP and improving antioxidant activity, leading to improved function and reduced tissue injury during ischemia and reperfusion.
Degradation and Remodeling of Small Intestinal Submucosa in Canine Achilles Tendon Repair (2007)

Small intestinal submucosa extracellular matrix is rapidly degraded after implantation for the repair of a musculotendinous tissue in this canine Achilles tendon repair model and is replaced by the deposition and organization of host tissue that is histologically similar to that of normal tissue.
응용논문 : 산업안전보건에 대한 정부규제에 관한 연구 (2000)

The purpose of this study is to analyze the adequacy of the regulatory policies on the industrial safety and health in Korea. The proper direction of government regulation to lower the industrial accidents and occupational disease to an appropriate level
Partitioning of sugars in <i>Lolium perenne</i> (perennial ryegrass) during drought and on rewatering (1999)

Simulated swards of perennial ryegrass ( Lolium perenne ) growing in 1‐m 3 soil blocks in the glasshouse were either well watered or deprived of water for 57 d and then rewatered. The first aim was to measure effects of drought on sugar (water‐soluble carbohydrate) composition of laminae and sheaths of mature laminae, and bases and laminae of young (growing) leaves. The second aim was to use pulse labelling with 14 CO 2 to follow the partitioning of recently‐fixed assimilates, and the assembly and consumption of reserve sugars (fructans). Over the last 7 d of drought growth almost stopped, old leaves died faster than they were replaced, and total sugar (which had doubled in concentration during drought) was rapidly consumed. Leaf laminae had lower content of total sugars and of large fructan (DP>5) than did growing bases and sheaths. Drought greatly reduced the rate at which sugar was exported from the laminae to the sheaths and growing leaf bases, and the rate at which it was converted to fructan. Nevertheless, fructan accumulated over the first 50 d of drought. Rewatering did not result in depolymerization and remobilization of sugars that had been formed during the last 7 d of drought, but stimulated their further assembly into high‐DP fructans. Our hypothesis, that accumulation of neo‐kestose (a DP‐3 fructan) in droughted laminae was a symptom of sugar remobilization just before death, was disproved. It is concluded that sugar reserves contribute to drought resistance only under extreme conditions. The specific role of fructan in dry environments might be to improve regrowth when drought is relieved, rather than to enhance growth during drought.
Gene set enrichment analysis for non-monotone association and multiple experimental categories (2008)

The proposed framework captures both linear and non-linear association between gene expression level and a phenotypic endpoint and thus can be viewed as extending the current GSEA/SAFE methodology. The framework for combining results from multiple GSEA/SAFE analyses is flexible to address practical inference interests. Our methods can be applied to microarray data with continuous phenotypes with multi-level design or the meta-analysis of multiple microarray data sets.
Effects of Manufacturing Process Conditions on Sensory Attributes and Microstructure of Ice Cream (2012)

The primary process parameters of the homogenization pressure and freezing process (drawing temperature and overrun) for ice cream manufacture were examined to determine their impact on the sensory attributes and odor sensor response of ice cream. Fifteen process conditions were selected using a Box-Behnken design, while 12 sensory attributes were obtained as assessment items based on sensory evaluations using quantitative descriptive analysis (QDA). Eleven of these sensory attributes changed significantly according to process conditions, suggesting that such conditions can have a major impact on ice cream's sensory attributes, even for a fixed make-up of ingredients. Furthermore, observed correlations between the sensory attributes and microstructural attributes of the ice cream led to the conjecture that the sensory attributes were influenced by changes to the ice cream's structural conditions resulting from the process conditions. A correlation was also observed between the odor sensor response and the overrun condition, but no clear correlations were found to exist within the ice cream structure or the sensory attributes.
Production of Inorganic Nanoparticles by Microorganisms (2009)

Abstract A promising new dimension in the field of biotechnology is the use of microorganisms for the production of inorganic nanoscale particles. The interest in nanotechnology is provoked by the unique properties of nanostructured materials and their potential fields of application ranging from medicine to electronics. This review article presents a systematic overview of the microorganisms capable of producing nanoparticles, and describes cellular mechanisms and outlines cultivation conditions that turn this process into a successful synthetic pathway.
Learning action models from plan examples with incomplete knowledge (2005)

AI planning requires the definition of an action model using a language such as PDDL as input. However, building an action model from scratch is a difficult and time-consuming task even for experts. In this paper, we develop an algorithm called ARMS for automatically discovering action models from a set of successful plan examples. Unlike the previous work in action-model learning, we do not assume complete knowledge of states in the middle of the example plans; that is, we assume that no intermediate states are given. This requirement is motivated by a variety of applications, including object tracking and plan monitoring where the knowledge about intermediate states is either minimal or unavailable to the observing agent. In a real world application, the cost is prohibitively high in labelling the training examples by manually annotating every state in a plan example from snapshots of an environment. To learn action models, our ARMS algorithm gathers knowledge on the statistical distribution of frequent sets of actions in the example plans. It then builds a propositional satisfiability (SAT) problem and solves it using a SAT solver. We lay the theoretical foundations of the learning problem and evaluate the effectiveness of ARMS empirically.
Large-Scale Learning with String Kernels (2007)

This chapter contains sections titled: Introduction, String Kernels, Sparse Feature Maps, Speeding up SVM Training and Testing, Benchmark Experiments, Extensions, Conclusion
Portal indígena: Desafíos para su desarrollo y supervivencia (2009)

El 9 de agosto se lanzo el Portal Global de los Pueblos Indigenas de las Americas: www.ictindigenousportal.org. Esta iniciativa pretende formar a un grupo de comunicadores indigenas en el manejo y produccion de informaciones en Internet. Lo innovador radica en la posibilidad de tener un espacio virtual para generar, administrar y difundir sus conocimientos a partir de sus propias visiones e iniciativas.
TGF‐β1 is an organizer of responses to neurodgeneration (1993)

TGF-beta 1 mRNA and protein were recently found to increase in animal brains after experimental lesions that cause local deafferentation or neuron death. Elevations of TGF-beta 1 mRNA after lesions are prominent in microglia but are also observed in neurons and astrocytes. Moreover, TGF-beta 1 mRNA autoinduces its own mRNA in the brain. These responses provide models for studying the increases of TGF-beta 1 protein observed in beta A/amyloid-containing extracellular plaques of Alzheimer's disease (AD) and Down's syndrome (DS) and in brain cells of AIDS victims. Involvement of TGF-beta 1 in these human brain disorders is discussed in relation to the potent effects of TGF-beta 1 on wound healing and inflammatory responses in peripheral tissues. We hypothesize that TGF-beta 1 and possibly other TGF-beta peptides have organizing roles in responses to neurodegeneration and brain injury that are similar to those observed in non-neural tissues. Work from many laboratories has shown that activities of TGF-beta peptides on brain cells include chemotaxis, modification of extracellular matrix, and regulation of cytoskeletal gene expression and of neurotrophins. Similar activities of the TGF-beta's are well established in other tissues.
Cloning, characterization, and modeling of a monoclonal anti‐human transferrin antibody that competes with the transferrin receptor (1994)

In this report we describe the isolation and characterization of a monoclonal antibody against human serum transferrin (Tf) and the cloning and sequencing of its cDNA. The antibody competes with the transferrin receptor (TR) for binding to human Tf and is therefore expected to bind at or very close to a region of interaction between Tf and its receptor. From the deduced amino acid sequence, we constructed a 3-dimensional model of the variable domains of the antibody based on the canonical structure model for the hypervariable loops. The proposed structure of the antibody is a first step toward a more detailed characterization of the antibody-Tf complex and possibly toward a better understanding of the Tf interaction with its receptor. The model might prove useful in guiding site-directed mutagenesis studies, simplifying the experimental elucidation of the antibody structure, and in the use of automatic procedures to dock the interacting molecules as soon as structural information about the structure of the human Tf molecule will be available.
Testing the 400 MHz IBM generation-4 CMOS chip (2002)

This paper describes the design-for-test framework of the 400 MHz CMOS central processor (CP) used in the fourth generation (G4) of the IBM S/390(R) line of servers. It will describe details of modeling logic to achieve correct and effective tests as well as describe the test sets required to test all portions of the design. This includes built-in self-test, array self-test, weighted random pattern generation, algorithmic pattern generation, and manual patterns. Tests are used to detect faults, static and dynamic, and to debug/diagnose chip failures characteristic to the function under test. The described tests ensure the highest reliability for the components within the system and the same test patterns can be applied from manufacturing all the way to the system level.
Studies on the antiobesity activity of tetrahydrolipstatin, a potent and selective inhibitor of pancreatic lipase. (1987)

In summary, THL is a potent inhibitor of pancreatic lipase, which is both selective and irreversible in its action in vitro. It is also likely that THL inhibits pancreatic lipase in vivo, since its acute administration to mice and squirrel monkeys suppresses absorption of dietary triglycerides, without an apparent alteration in the absorption of fatty acids. The marked loss in body weight and carcass fat of DIO rats with subchronic administration of THL strongly suggests that inhibition of pancreatic lipase is a feasible strategy for the treatment of obesity. Whether obese humans will overeat in response to a reduction in body energy stores is not known. However, it is probable that compliance to a therapy which maintains the present level of food intake while inducing excretion of dietary fat, will be greater than a reducing diet alone or conjunction with the currently available antiobesity drugs.
Cancer Stem Cells (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Systematic errors in conductimetric instrumentation due to bubble adhesions on the electrodes: An experimental assessment (1985)

Systematic errors in conductimetric measurements are often encountered due to partial screening of interelectrode current paths resulting from adhesion of bubbles on the electrode surfaces of the cell. A method of assessing this error quantitatively by a simulated electrolytic tank technique is proposed here. The experimental setup simulates the bubble-curtain effect in the electrolytic tank by means of a pair of electrodes partially covered by a monolayer of small polystyrene-foam spheres representing the bubble adhesions. By varying the number of spheres stuck on the electrode surface, the fractional area covered by the bubbles is controlled; and by measuring the interelectrode impedance, the systematic error is determined as a function of the fractional area covered by the simulated bubbles. A theoretical model which depicts the interelectrode resistance and, hence, the systematic error caused by bubble adhesions is calculated by considering the random dispersal of bubbles on the electrodes. Relevant computed results are compared with the measured impedance data obtained from the electrolytic tank experiment. Results due to other models are also presented and discussed. A time-domain measurement on the simulated cell to study the capacitive effects of the bubble curtain is also explained.
Alterations in <i>TCF7L2</i> expression define its role as a key regulator of glucose metabolism (2011)

Genome-wide association studies (GWAS) have consistently implicated noncoding variation within the TCF7L2 locus with type 2 diabetes (T2D) risk. While this locus represents the strongest genetic determinant for T2D risk in humans, it remains unclear how these noncoding variants affect disease etiology. To test the hypothesis that the T2D-associated interval harbors cis-regulatory elements controlling TCF7L2 expression, we conducted in vivo transgenic reporter assays to characterize the TCF7L2 regulatory landscape. We found that the 92-kb genomic interval associated with T2D harbors long-range enhancers regulating various aspects of the spatial-temporal expression patterns of TCF7L2, including expression in tissues involved in the control of glucose homeostasis. By selectively deleting this interval, we establish a critical role for these enhancers in robust TCF7L2 expression. To further determine whether variation in Tcf7l2 expression may lead to diabetes, we developed a Tcf7l2 copy-number allelic series in mice. We show that a null Tcf7l2 allele leads, in a dose-dependent manner, to lower glycemic profiles. Tcf7l2 null mice also display enhanced glucose tolerance coupled to significantly lowered insulin levels, suggesting that these mice are protected against T2D. Confirming these observations, transgenic mice harboring multiple Tcf7l2 copies and overexpressing this gene display reciprocal phenotypes, including glucose intolerance. These results directly demonstrate that Tcf7l2 plays a role in regulating glucose tolerance, suggesting that overexpression of this gene is associated with increased risk of T2D. These data highlight the role of enhancer elements as mediators of T2D risk in humans, strengthening the evidence that variation in cis-regulatory elements may be a paradigm for genetic predispositions to common disease.