gebhart/patrepeval huggingface dataset:
General-purpose LSM learning processor architecture and theoretically guided design space exploration (2015)

This paper presents a general-purpose liquid state machine based neuromorphic learning processor with integrated training and recognition for real world pattern recognition problems. The proposed architecture consists of a generic preprocessor and one or multiple task processors. The pre-processor, or the reservoir, consists of a recurrent spiking neural network with fixed synaptic weights. Task processors are light weight and comprise a set of readout spiking neurons with plastic weights, which are tuned by a biologically plausible supervised learning rule. Importantly, we leverage the unique computational structure of the reservoir for highly efficient implementation of multiple tasks on the same learning processor. A novel theoretical measure of computational power, which is strongly correlated with the true learning performance, is proposed to facilitate fast design space exploration of the recurrent reservoir. We demonstrate the application of our processor architecture by mapping four recognition tasks onto a reconfigurable FPGA processor platform.
Differential access points for indoor location estimation (2009)

Location positioning systems using Wi-Fi infrastructure are considered cost effective and practical solutions for indoor location tracking and estimation. However, accuracy deterioration due to environmental factors and the need for manual offline calibration limit the application of these systems. In this paper, a new method based on differential operation access points is proposed to eliminate the adverse effects of environmental factors on location estimation using Wi-Fi based systems. Experimental measurement results indicate that the proposed method can effectively reduce the positioning errors introduced by path loss variation over time due to changes in environmental dynamics.
Peritonitis: Update on Pathophysiology, Clinical Manifestations, and Management (1997)

by directly traversing the intact intestinal wall. In an animal Although primary peritonitis may occur in children without model, Escherichia coli passes from the bowel into the peritopredisposing disease, it is especially associated with post- neal cavity after the introduction of hypertonic solutions into necrotic cirrhosis and nephrotic syndrome. In adults, primary the peritoneum. The infrequent occurrence of bacteremia and peritonitis develops in up to 25% of patients with alcoholic the multiplicity of species in peritoneal fluid when anaerobic cirrhosis but has also been reported to occur in adults with bacteria are involved suggest that transmural migration of bacpostnecrotic cirrhosis, chronic active hepatitis, acute viral hepa- teria is the probable route of infection of ascitic fluid in most of these patients. In prepubertal girls, the pathogenesis of primary peritonitis is likely related to an ascending infection of genital origin, as
Effect of Added Moisture on the Heat Resistance of <i>Salmonella anatum</i> in Milk Chocolate (1970)

The heat resistance of Salmonella anatum in milk chocolate at a processing temperature (71 C) was greatly decreased by adding 1 to 4% moisture.
Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9 (2016)

Progressive multifocal leukoencephalopathy (PML) is a debilitating disease resulting from infection of oligodendrocytes by the JC polyomavirus (JCPyV). Currently, there is no anti-viral therapeutic available against JCPyV infection. The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system (CRISPR/Cas9) is a genome editing tool capable of introducing sequence specific breaks in double stranded DNA. Here we show that the CRISPR/Cas9 system can restrict the JCPyV life cycle in cultured cells. We utilized CRISPR/Cas9 to target the noncoding control region and the late gene open reading frame of the JCPyV genome. We found significant inhibition of virus replication and viral protein expression in cells recipient of Cas9 together with JCPyV-specific single-guide RNA delivered prior to or after JCPyV infection.
An approach to consistent jitter modeling for various jitter aspects and measurement methods (2002)

Timing jitter, period jitter, long term jitter, jitter spectrum, SSB phase noise, etc. are terms that have been used to describe various aspects of jitter phenomena. While several jitter measurement techniques have been proposed with associated jitter models and modeling techniques, the relationship among various jitter aspects, and therefore, the relationship among various jitter measurement techniques is not very obvious. This paper analytically clarifies their relationship, and reviews several jitter measurement techniques based on the results of our analytical studies.
Effect of curcumin on apoptosis and bFGF expression in lymphoma Raji cells (2013)

OBJECTIVE:To detect the effects of curcumin on apoptosis and bFGFs′expression in Raji cells,and provide a theory evidence for therapy of anti-vessel neogenesis.METHODS:After Raji cells were treated with curcumin at different concentrations and different time,the morphological changes of cells were observed by inverted phase contrast microscope,and the cell apoptosis was tested by flow cytometry;the change of bFGF contents in cultured supernatants of Raji cells treated with different concentratins of curcumin were measured by ELISA.RESULTS:The morphological changes of cells were observed by inverted phase contrast microscope,the Raji cells turned into disorder from conglobation,the cell population obviously was decreased and the cell volume shrinked,the refraction weakened,the cell membrance disrupted,cell debris existed.The apoptosis rate of Raji cells was increased as the concentration of curcumin and action time were increased.When curcumin concentrations were 10 and 25 μmol/L,the apoptosis rate of Raji cells were(11.12±1.05)%,(25.07±5.40)% after 24 h,(14.74±0.46)%,(33.50±5.89)% after 48 h and(25.11±1.43)%,(55.98±7.41)% after 72 h,which were higher than that of control group [(1.75±0.28)%,(2.25±0.29)%,(2.77±0.61)%] and there was a significant difference(P0.01).The change of bFGF contents in cultured supernatants of Raji cells treated with different concentratins of curcumin(10,25 μmol/L),in different time(24,48,72 h)were measured by ELISA,the 10 μmol/L curcumin group levels of bFGF were(212.76±20.07),(173.23±14.76) and(107.21±12.37) ρg/mL;the 25 μmol/L curcumin group levels of bFGF were(95.32±11.59),(71.24±10.03) and(36.41±7.58) ρg/mL,significantly lower than that of the control groups(643.41±57.12),(732.26±60.19) and(931.27±81.04) ρg/mL.CONCLUSIONS:Curcumin can promote the Raji cells apoptosis,inhibit bFGF secretion of Raji cells and this function is relied on concentrations and times.These results suggest that curcumin may be anti-vessel neogenesis.
Creating Effective Nanoreactors on Carbon Nanotubes with Mechanochemical Treatments for High‐Areal‐Capacity Sulfur Cathodes and Lithium Anodes (2018)

Abstract Li‐S batteries can potentially deliver high energy density and power, but polysulfide shuttle and lithium dendrite formations on Li metal anode have been the major hurdle. The polysulfide shuttle becomes severe particularly when the areal loading of the active material (sulfur) is increased to deliver the high energy density and the charge/discharge current density is raised to deliver high power. This study reports a novel mechanochemical method to create trenches on the surface of carbon nanotubes (CNTs) in free‐standing 3D porous CNT sponges. Unique spiral trenches are created by pressures during the chemical treatment process, providing polysulfide‐philic surfaces for cathode and lithiophilic surfaces for anode. The Li‐S cells made from manufacturing‐friendly sulfur‐sandwiched cathodes and lithium‐infused anodes using the mechanochemically treated electrodes exhibit a strikingly high areal capacity as high as 13.3 mAh cm −2 , which is only marginally reduced even with a tenfold increase in current density (16 mA cm −2 ), demonstrating both high “cell‐level” energy density and power. The outstanding performance can be attributed to the significantly improved reaction kinetics and lowered overpotentials coming from the reduced interfacial resistance and charge transfer resistance at both cathodes and anodes. The trench–wall CNT sponge simultaneously tackles the most critical problems on both the cathodes and anodes of Li‐S batteries, and this method can be utilized in designing new electrode materials for energy storage and beyond.
<title>Combined photoacoustic and fluorescent quenching studies on organic dyes</title> (1992)

The development of deconvolution techniques in pulsed-laser, time-resolved photoacoustics has opened the possibility of accurately distinguishing between processes occurring on different time scales, and has given photoacoustics better resolution in determining reaction enthalpies and quantum yields. While fluorescent signals are usually generated by a single de- excitation pathway in the fluorophore, photoacoustic signals usually arise from different sources, such as excited singlet and triplet deactivation, occurring on well-distinguished time scales. The understanding of the effect of quenching on photoacoustic signals therefore requires careful analysis of the data. In this work, a model is developed to describe the effect of fluorescence quenching on photoacoustic signals. The model takes advantage of the time resolution in pulsed-laser photoacoustics. Both static and dynamic quenching are taken into account. Important photophysical parameters (fluorescence and intersystem crossing quantum yields, the bimolecular quenching rate constant, and the volume of the sphere of action) appear in the expressions describing the dependence of photoacoustic signal on quencher concentration. Data from both steady-state fluorescence and time-resolved photoacoustic quenching measurements are analyzed simultaneously using a set of equations containing common parameters. Experimental data on the quenching of organic dyes are presented which support the validity of the model.
Synthesis of Enantiomerically Pure (−)-Wine Lactone Based on a Palladium-Catalyzed Enantioselective Allylic Substitution (2000)

The first enantioselective synthesis of enantiomerically pure (−)-wine lactone, (−)-1a, a fragrance constituent of various white wines, and its epimer (+)-1b, was carried out. The key steps are allylic substitution of (±)-2-cyclohexen-1-yl acetate (2) with dimethylmalonate using palladium complexes of phosphanyldihydrooxazol L1 or of the phosphanylcarboxylic acid L2 as catalyst, subsequent decarboxylation, iodolactonization and elimination, furnishing enantiomerically pure bicyclic lactone (+)-7 in 47% overall yield. The diastereoselective introduction of methyl groups by SN2′-type substitution with an organocopper compound and by enolate alkylation gave lactone (−)-1a in 43% overall yield from (+)-7.
The Mainlandization of Hong Kong (2008)

On July 1, 1997, Hong Kong was returned of its sovereignty from Britain to the People's Republic of China (PRC). Since its freedom from the British reign, its political development proved to be turbulent. This chapter examines the different factors contributing to the crisis in Hong Kong's governance. Of the several factors fuelling the governance crisis in HKSAR is the existence of tension between convergence and divergence. While the concept of “one country” has been pushing Hong Kong to toward a system politically similar to PRC, the demands of maintaining the concept of “two systems” proved to be a hindrance to the policy intentions of Beijing and Hong Kong. This chapter begins with a discussion on the latter period of the Tung Chee-hwa administration. The succeeding sections tackle the theory of convergence and explore how the political and economic dimensions of convergence unfolded in Hong Kong since its devolution. In addition, the chapter discusses the mainlandization strategy of the Donald Tsang administration including the dilemmas of recolonizing Hong Kong polity, and the consequences of the Hong Kong's politico-economic convergence with mainland China.
Axe–Txe, a broad‐spectrum proteic toxin–antitoxin system specified by a multidrug‐resistant, clinical isolate of <i>Enterococcus faecium</i> (2003)

Enterococcal species of bacteria are now acknowledged as leading causes of bacteraemia and other serious nosocomial infections. However, surprisingly little is known about the molecular mechanisms that promote the segregational stability of antibiotic resistance and other plasmids in these bacteria. Plasmid pRUM (24 873 bp) is a multidrug resistance plasmid identified in a clinical isolate of Enterococcus faecium. A novel proteic-based toxin-antitoxin cassette identified on pRUM was demonstrated to be a functional segregational stability module in both its native host and evolutionarily diverse bacterial species. Induced expression of the toxin protein (Txe) of this system resulted in growth inhibition in Escherichia coli. The toxic effect of Txe was alleviated by co-expression of the antitoxin protein, Axe. Homologues of the axe and txe genes are present in the genomes of a diversity of Eubacteria. These homologues (yefM-yoeB) present in the E. coli chromosome function as a toxin-antitoxin mechanism, although the Axe and YefM antitoxin components demonstrate specificity for their cognate toxin proteins in vivo. Axe-Txe is one of the first functional proteic toxin-antitoxin systems to be accurately described for Gram-positive bacteria.
Infoseek's experiences searching the internet (1998)

article Infoseek's experiences searching the internet Share on Author: Steven Kirsch Infoseek Corp., Sunnyvale, CA Infoseek Corp., Sunnyvale, CAView Profile Authors Info & Claims ACM SIGIR ForumVolume 32Issue 2Sept. 1998 pp 3–7https://doi.org/10.1145/305110.305112Online:01 September 1998Publication History 33citation513DownloadsMetricsTotal Citations33Total Downloads513Last 12 Months7Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Transient and steady-state antenna pattern characteristics for arbitrary time signals (1964)

Abstract : This report presents a simplified method for the analytical determination of the transient and steady state pattern characteristics of an antenna for arbitrary time signals and arbitrary aperture distributions. For uniform aperture illumination, the pattern response of an antenna for any time signal, no matter how complicated, can be found through simple shifts of the signal, and both the transient and the steady-state behavior can be determined without performing any integration. Examples are given for responses to suddenly applied excitations, to rectangular pulses, to excitations for electronic scanning, and to time signals in a pulse compression system. For pulse signals, a steady state is not reached in any given direction, theta, if the duration of the pulse T is less than (a/c) sin theta, where a is maximum aperture dimension and c is velocity of light. Graphical representations for easy interpretation of the different states of pattern characteristics are included.
Validation of a Novel Approach for Dose Individualization in Pharmacotherapy Using Gabapentin in a Proof of Principles Study (2013)

IDCs display the risk of a patient violating the target concentration range for any dosage regimen. They can be used as a clinical-bedside decision-support tool in a patient-physician partnership to decide on a dose amount and dosing interval that are medically acceptable while practical and convenient to ensure compliance. By using the assumption-free Bayesian approach and the OSS, the number of samples required from a new patient to individualize the dosage regimen can be reduced significantly while preserving high levels of sensitivity and specificity. Prospective studies are being planned to validate the encouraging results. This approach can be extended to any drug if PK data and a target concentration range are available for either therapeutic drug monitoring or target concentration intervention.
FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion (2016)

Gastric cancer is the fourth most common type of cancer and second leading cause of cancer-related death in the world. Since patients are often diagnosed at a late stage, very few effective therapies are left in the arsenal. FGF19, as a hormone, has been reported to promote tumor growth in various types of cancer; however, its function in gastric cancer remains unknown. In the current study, we showed that FGF19 is overexpressed in gastric cancer and is associated with depth of invasion, lymph node metastasis, and TNM stage. In addition, in vitro experiments demonstrated that FGF19 is able to enhance migration and invasion abilities of gastric cancer cells. Given its great potency in gastric cancer progression, FGF19 may be an effective target of treatment for advanced gastric cancer patients.
Interactive task planning in virtual assembly (1999)

We propose a task planner that incorporates with a virtual reality interface for 3D immersive interaction of CAD models and high-level task planning of mating processes. The planner is constructed with the following objectives: 3D immersive VR interface, assembly analysis, feature/constraint update, and assembly path planning.
Integrated Imaging Approach with MEG and DTI to Detect Mild Traumatic Brain Injury in Military and Civilian Patients (2009)

Traumatic brain injury (TBI) is a leading cause of sustained impairment in military and civilian populations. However, mild (and some moderate) TBI can be difficult to diagnose due to lack of obvious external injuries and because the injuries are often not visible on conventional acute MRI or CT. Injured brain tissues in TBI patients generate pathological low-frequency neuronal magnetic signal (delta waves 1-4 Hz) that can be measured and localized by magnetoencephalography (MEG). We hypothesize that abnormal MEG delta waves originate from gray matter neurons that experience de-afferentation due to axonal injury to the underlying white matter fiber tracts, which is manifested on diffusion tensor imaging (DTI) as reduced fractional anisotropy. The present study used a neuroimaging approach integrating findings of magnetoencephalography (MEG) and diffusion tensor imaging (DTI), evaluating their utility in diagnosing mild TBI in 10 subjects in whom conventional CT and MRI showed no visible lesions in 9. The results show: (1) the integrated approach with MEG and DTI is more sensitive than conventional CT and MRI in detecting subtle neuronal injury in mild TBI; (2) MEG slow waves in mild TBI patients originate from cortical gray matter areas that experience de-afferentation due to axonal injuries in the white matter fibers with reduced fractional anisotropy; (3) findings from the integrated imaging approach are consistent with post-concussive symptoms; (4) in some cases, abnormal MEG delta waves were observed in subjects without obvious DTI abnormality, indicating that MEG may be more sensitive than DTI in diagnosing mild TBI.
Preface (2014)

UOJM Volume 4 Issue 2 marks a significant milestone for UOJM. For the first time, UOJM has sustained activity over the summer due to increased interest and submissions, which has resulted in the release of multiple issues in a year. Our second issue reflects an increase in awareness and support for UOJM both internally at the University of Ottawa and externally. We have made several infrastructure upgrades to accommodate the high volume of submissions, including the implementation of the Open Journal Systems platform hosted through the University of Ottawa Library as a peer review management platform, content manager, anddigital archive. We have also expanded our effort to use social media platforms such as Facebook, Twitter, LinkedIn and Google+ to provide day-to-day communication to our followers around the world.
Development of a High-Throughput Screening Assay for Inhibitors of Small Ubiquitin-Like Modifier Proteases (2013)

Small ubiquitin-like modifier (SUMO1-3) is a small group of proteins that are ligated to lysine residues in target proteins. SUMO conjugation is a highly dynamic process, as SUMOylated proteins are rapidly deconjugated by SUMO proteases. SUMO conjugation/deconjugation plays pivotal roles in major cellular pathways and is associated with a number of pathological conditions. It is therefore of significant clinical interest to develop new strategies to screen for compounds to specifically interfere with SUMO conjugation/deconjugation. Here, we describe a novel high-throughput screening (HTS)-compatible assay to identify inhibitors of SUMO proteases. The assay is based on AlphaScreen technology and uses His-tagged SUMO2 conjugated to Strep-tagged SUMO3 as a SUMO protease substrate. A bacterial SUMOylation system was used to generate this substrate. A three-step purification strategy was employed to yield substrate of high quality. Our data indicated that this unique substrate can be readily detected in the AlphaScreen assays in a dose-dependent manner. Cleavage reactions by SUMO protease with or without inhibitor were monitored based on AlphaScreen signals. Furthermore, the assay was adapted to a 384-well format, and the interplate and interday variability was evaluated in eight 384-well plates. The average Z' factor was 0.83 ± 0.04, confirming the suitability for HTS applications.
Reactivation of Androgen Receptor–Regulated <i>TMPRSS2:ERG</i> Gene Expression in Castration-Resistant Prostate Cancer (2009)

It seems clear that androgen receptor (AR)-regulated expression of the TMPRSS2:ERG fusion gene plays an early role in prostate cancer (PC) development or progression, but the extent to which TMPRSS2:ERG is down-regulated in response to androgen deprivation therapy (ADT) and whether AR reactivates TMPRSS2:ERG expression in castration-resistant PC (CRPC) have not been determined. We show that ERG message levels in TMPRSS2:ERG fusion-positive CRPC are comparable with the levels in fusion gene-positive primary PC, consistent with the conclusion that the TMPRSS2:ERG expression is reactivated by AR in CRPC. To further assess whether TMPRSS2:ERG expression is initially down-regulated in response to ADT, we examined VCaP cells, which express the TMPRSS2:ERG fusion gene, and xenografts. ERG message and protein rapidly declined in response to removal of androgen in vitro and castration in vivo. Moreover, as observed in the clinical samples, ERG expression was fully restored in the VCaP xenografts that relapsed after castration, coincident with AR reactivation. AR reactivation in the relapsed xenografts was also associated with marked increases in mRNA encoding AR and androgen synthetic enzymes. These results show that expression of TMPRSS2:ERG, similarly to other AR-regulated genes, is restored in CRPC and may contribute to tumor progression.