gebhart/patrepeval huggingface dataset:
Distribution of water losses among fluid compartments of tissues under thermal dehydration in the rat. (1983)

Dehydration amounting to about 10% of body weight was induced in adult male rats by exposure to a hot, dry environment (D.B.T., 36 degrees C; R.H., 20%) over 6 to 8 hr. The volumes of total water (TW), extracellular fluid (ECF), and plasma (PV) were determined both on individual tissues and on the whole body using the constant dry weight as well as 51Cr-EDTA and 125I-RIHSA dilution methods. Total body water (TBW), intracellular (ICF), and interstitial (ISF) fluid volumes were calculated from these data. The 10% loss of body weight caused a decrease in TBW by 17% from the control value; 41% of this loss was from ICF, 47% from ISF, and 12% from PV. The decrease of ISF was proportional to that of PV and the water loss from ICF was caused by an increase in plasma osmolality. As to the water loss from organs, 40% of the whole body water loss came from muscle, 30% from skin, 14% from bone, and 14% from viscera. The G.I. tract had the highest tendency to lose water while the brain and liver showed the least. These findings suggest that under heat-induced dehydration, both the extra- and intracellular fluid compartments of muscle and skin play an important role in the compensation of water loss and in the maintenance of circulation to the brain and liver.
iWIRES (2009)

Man-made objects are largely dominated by a few typical features that carry special characteristics and engineered meanings. State-of-the-art deformation tools fall short at preserving such characteristic features and global structure. We introduce iWIRES, a novel approach based on the argument that man-made models can be distilled using a few special 1D wires and their mutual relations. We hypothesize that maintaining the properties of such a small number of wires allows preserving the defining characteristics of the entire object. We introduce an analyze-and-edit approach, where prior to editing, we perform a light-weight analysis of the input shape to extract a descriptive set of wires. Analyzing the individual and mutual properties of the wires, and augmenting them with geometric attributes makes them intelligent and ready to be manipulated. Editing the object by modifying the intelligent wires leads to a powerful editing framework that retains the original design intent and object characteristics. We show numerous results of manipulation of man-made shapes using our editing technique.
THE WEIGHTED MAJORITY ALGORITHM (Supersedes 89-16) (1992)

We study the construction of prediction algorithms in a situation in which a learner faces a sequence of trials, with a prediction to be made in each, and the goal of the learner is to make few mistakes. We are interested in the case that the learner has reason to believe that one of some pool of known algorithms will perform well, but the learner does not know which one. A simple and effective method, based on weighted voting, is introduced for constructing a compound algorithm in such a circumstance. We call this method the Weighted Majority Algorithm. We show that this algorithm is robust in the presence of errors in the data. We discuss various versions of the Weighted Majority Algorithm and prove mistake bounds for them that are closely related to the mistake bounds of the best algorithms of the pool. For example, given a sequence of trials, if there is an algorithm in the pool A that makes at most m mistakes then the Weighted Majority Algorithm will make at most c(log |A| + m) mistakes on that sequence, where c is fixed constant.
Selenomethionine and Selenium Yeast: Appropriate Forms of Selenium for Use in Infant Formulas and Nutritional Supplements (1998)

Because the natural selenium content of infant formulas is generally low, selenium fortification is necessary to improve the selenium status of formula-fed infants. The question as to the form of selenium to be used for this purpose is an important one. Ideally, selenium should be supplemented in the same form in which it occurs normally in human milk. Sodium selenate or sodium selenite, which are used currently, do not occur normally in foods. Virtually all the selenium present in human milk is organic and significantly in the form of selenomethionine. Selenomethionine could be added to infant formulas in the form of selenium yeast or selenium yeast hydrolyzates.
The GeneOptimizer Algorithm: using a sliding window approach to cope with the vast sequence space in multiparameter DNA sequence optimization (2010)

One of the main advantages of de novo gene synthesis is the fact that it frees the researcher from any limitations imposed by the use of natural templates. To make the most out of this opportunity, efficient algorithms are needed to calculate a coding sequence, combining different requirements, such as adapted codon usage or avoidance of restriction sites, in the best possible way. We present an algorithm where a "variation window" covering several amino acid positions slides along the coding sequence. Candidate sequences are built comprising the already optimized part of the complete sequence and all possible combinations of synonymous codons representing the amino acids within the window. The candidate sequences are assessed with a quality function, and the first codon of the best candidates' variation window is fixed. Subsequently the window is shifted by one codon position. As an example of a freely accessible software implementing the algorithm, we present the Mr. Gene web-application. Additionally two experimental applications of the algorithm are shown.
Structure-Sweetness Relationship in Thaumatin: Importance of Lysine Residues (2001)

To clarify the structural basis for the sweetness of thaumatin I, lysine-modified derivatives and carboxyl-group-modified derivatives were prepared by chemical modification followed by chromatographic purification. The sweetness of derivatives was evaluated by sensory analysis. Phosphopyridoxylation of lysine residues Lys78, Lys97, Lys106, Lys137 and Lys187 markedly reduced sweetness. The intensity of sweetness was returned to that of native thaumatin by dephosphorylation of these phosphopyridoxylated lysine residues except Lys106. Pyridoxamine modification of the carboxyl group of Asp21, Glu42, Asp60, Asp129 or Ala207 (C-terminal) did not markedly change sweetness. Analysis by far-UV circular dichroism spectroscopy indicated that the secondary structure of all derivatives remained unchanged, suggesting that the loss of sweetness was not a result of major disruption in protein structure. The five lysine residues, modification of which affected sweetness, are separate and spread over a broad surface region on one side of the thaumatin I molecule. These lysine residues exist in thaumatin, but not in non-sweet thaumatin-like proteins, suggesting that these lysine residues are required for sweetness. These lysine residues may play an important role in sweetness through a multipoint interaction with a putative thaumatin receptor.
Phase-Change Media for High-Numerical-Aperture and Blue-Wavelength Recording (2001)

We have studied the feasibility of doped eutectic SbTe alloys for practical application in digital video recording (DVR) rewritable phase-change media for high-numerical-aperture (NA=0.85) and blue-wavelength (λ=405 nm) recording. Remaining issues such as thermal cross-erase in land/groove recording and the thermal stability of recorded amorphous marks have been investigated and resolved. This work has resulted in the realisation of 22.5 GB phase-change media complying with the DVR blue format. The future of doped eutectic SbTe alloys in the phase-change recording-speed race is also promising, as the crystallisation speed and archival life stability can be optimised more or less independently by tuning the Sb/Te atomic ratio and adding Ge, respectively. We have demonstrated that a user data transfer rate of 70 Mbit/s (DVR double speed) is within reach using our current phase-change composition, and are expecting to realise data rates of over 100 Mbit/s in the near future.
Scalable Techniques for Clustering the Web (Extended Abstract) (2000)

Clustering is one of the most crucial techniques for dealing with the massive amount of information present on the web. Clustering can either be performed once offline, independent of search queries, or performed online on the results of search queries. Our offline approach aims to efficiently cluster similar pages on the web, using the technique of Locality-Sensitive Hashing (LSH), in which web pages are hashed in such a way that similar pages have a much higher probability of collision than dissimilar pages. Our preliminary experiments on the Stanford WebBase have shown that the hash-based scheme can be scaled to millions of urls.
A 100Mbps, 0.19mW asynchronous threshold detector with DC power-free pulse discrimination for impulse UWB receiver (2009)

An asynchronous threshold detector for DC-960MHz band impulse ultra-wideband (UWB) receiver is proposed in this paper. It features a DC power-free pulse discriminator. The proposed architecture in 90nm CMOS achieves the lowest power consumption of 0.19mW and energy consumption of 1.9pJ/bit at 100Mbps in the UWB receiver.
A GaN HEMT Structure Allowing Self-Terminated, Plasma-Free Etching for High-Uniformity, High-Mobility Enhancement-Mode Devices (2016)

In this letter, a plasma-free etch stop structure is developed for GaN HEMT toward enhancement-mode operation. The self-terminated precision gate recess is realized by inserting a thin AlN/GaN bilayer in the AlGaN barrier layer. The gate recess is stopped automatically at the GaN insertion layer after high-temperature oxidation and wet etch, leaving a thin AlGaN barrier to maintain a quantum well channel that is normally pinched off. With addition of an Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> gate dielectric, quasi normally OFF GaN MOSHEMTs have been fabricated with high threshold uniformity and low ON-resistance comparable with the normally ON devices on the same wafer. A high channel mobility of 1400 cm <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$^{2}/\textrm {V}\cdot \textrm {s}$ </tex-math></inline-formula> was obtained due to the preservation of the high electron mobility in the quantum-well channel under the gate.
Annular (HSURIA) resonators: some experimental studies including polarization effects (1980)

A repetitively pulsed CO(2) laser facility was developed for testing annular resonators. The large-aperture device exhibits generally uniform gain over an annular region of 18-cm o.d. and 10-cm i.d. The half-symmetric unstable resonator with internal axicon (HSURIA) was tested at equivalent Fresnel numbers up to 4.5. This resonator design incorporates a W-axicon mirror beam compactor that transforms a cylindricalmode region into an annular-mode region. Two HSURIA configurations were evaluated: (a) with a conical end mirror and (b) with a flat end mirror in the annular leg. With the conical end mirror, the aligned resonator produced a predominantly higher-order azimuthal mode with an on-axis null in the far field. The output was strongly linearly polarized with the electric-field vector tangential to the optic axis in both the near and far fields. The higher-order tangentially polarized mode appears to be the result of a geometric polarization scrambling effect caused by the conical end mirror. The boundary conitions for the conical or W-axicon mirrors imply that the radial electric field has a 180 degrees phase shift on reflection, whereas the tangential component is unchanged. Thus, a tangentially polarized mode is self-reproducing, but a linearly polarized mode is not. To eliminate the polarization scrambling effect in the HSURIA, the conical end mirror was replaced with a flat end mirror. The HSURIA with a flat end mirror produced a central spot in the far field that indicated an l = 0 mode with no spatial variations in polarization. Beam quality was measured in terms of the ratio n(2) of the theoretical (geometric-mode) power transmitted through an aperture of the central lobe diameter to the observed power; n(2) values as low as 1.2 were obtained. The variation of beam quality with tilt of the flat end mirror indicated a factor of 2 degradation in n(2) for a 20-microrad tilt, which is in good agreement with theory.
Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity (2016)

Alzheimer's disease (AD) is the most abundant tauopathy and is characterized by Aβ-derived plaques and tau-derived tangles, resulting from the unfolding of the corresponding monomeric subunits into ordered β-sheet oligomers and fibrils. Intervening in the toxic aggregation process is a promising therapeutic approach, but, to date, a disease-modifying therapy is neither available for AD nor for other tauopathies. Along these lines, we have previously demonstrated that a small naphthoquinone-tryptophan hybrid, termed NQTrp, is an effective modulator of tauopathy in vitro and in vivo. However, NQTrp is difficult to synthesize and is not very stable. Therefore, we tested whether a more stable and easier-to-synthesize modified version of NQTrp, containing a Cl ion, namely Cl-NQTrp, is also an effective inhibitor of tau aggregation in vitro and in vivo. Cl-NQTrp was previously shown to efficiently inhibit the aggregation of various amyloidogenic proteins and peptides. We demonstrate that Cl-NQTrp inhibits the in vitro assembly of PHF6, the aggregation-prone fragment of tau, and alleviates tauopathy symptoms in a transgenic Drosophila model through the inhibition of tau aggregation-engendered toxicity. These results suggest that Cl-NQTrp could be a unique potential therapeutic for AD since it targets aggregation of both Aβ and tau.
The effects of auditory stimulation with music on heart rate variability in healthy women (2013)

We suggest that relaxant baroque and excitatory heavy metal music slightly decrease global heart rate variability because of the equivalent sound level.
Long-term survival with glioblastoma multiforme (2007)

The median survival of glioblastoma patients is approximately 12 months. However, 3-5% of the patients survives for more than 3 years and are referred to as long-term survivors. The clinical and molecular factors that contribute to long-term survival are still unknown. To identify specific parameters that might be associated with this phenomenon, we performed a detailed clinical and molecular analysis of 55 primary glioblastoma long-term survivors recruited at the six clinical centres of the German Glioma Network and one associated centre. An evaluation form was developed and used to document demographic, clinical and treatment-associated parameters. In addition, environmental risk factors, associated diseases and occupational risks were assessed. These patients were characterized by young age at diagnosis and a good initial Karnofsky performance score (KPS). None of the evaluated socioeconomic, environmental and occupational factors were associated with long-term survival. Molecular analyses revealed MGMT hypermethylation in 28 of 36 tumours (74%) investigated. TP53 mutations were found in 9 of 31 tumours (29%) and EGFR amplification in 10 of 38 tumours (26%). Only 2 of 32 tumours (6%) carried combined 1p and 19q deletions. Comparison of these data with results from an independent series of 141 consecutive unselected glioblastoma patients registered in the German Glioma Network revealed significantly more frequent MGMT hypermethylation in the long-term survivor group. Taken together, our findings underline the association of glioblastoma long-term survival with prognostically favourable clinical factors, in particular young age and good initial performance score, as well as MGMT promoter hypermethylation.
Design of a Workflow-Based Grid Framework (2015)

This paper aims to present the design of the Grid Collaborative Framework which has been proposed in one of our previous work. Grid infrastructure for resources sharing is somewhat stable with the wide acceptance of the Open Grid Services Architecture (OGSA) and Web Services Resource Framework (WSRF), but Grid framework for collaboration is far from desired. Current Grid Collaborative Frameworks (GCFs) are domain specific and lack of plan-supported capability. These limitations make them less useful and narrow in scope of application. Our grid collaborative framework aims to improve these limitations. With the theoretical foundation based on the activity theory, workflow languages, and designed on top of existing OGSA infrastructure, our proposed framework aims at accelerating the development of grid collaborative systems that consider work plans as central role.
Inhibition of acetyl‐coenzyme a carboxylase by the novel grass‐selective herbicide 3‐(2,4‐dichlorophenyl)‐perhydroindolizine‐2,4‐dione (1991)

Abstract The novel herbicidal compound 3‐(2,4‐dichlorophenyl)‐perhydroindolizine‐2,4‐dione which is active as a pre‐ and post‐emergence grass‐selective herbicide is a new type of inhibitor of plant acetyl‐coenzyme A carboxylase (ACCase; E.C. 6.4.1.2). This has been demonstrated by in‐vitro experiments using isolated corn enzyme. Besides an I 50 value of 4.7 μM under the assay conditions used, a mixed‐type inhibitory activity on the enzyme is established. The compound is inactive on rat liver A CCase enzyme and shows decreased activity (pI 50 less than 3.0) on the spinach enzyme.
Social media a new way to care and communicate. (2012)

Social media's rise to prominence is changing the way we communicate with each other at a rapid rate. With the click of a button we can send and receive information instantly that can be shared with thousands of others worldwide. While many industries have embraced the benefits of social media, health care has been slow to jump on board. Kathryn Anderson investigates the opportunities and the risks social media can bring to health care and the nursing and midwifery professions.
INDUCTION OF TH1 AND TH2 CD4<sup>+</sup>T CELL RESPONSES:The Alternative Approaches (1997)

T helper lymphocytes can be divided into two distinct subsets of effector cells based on their functional capabilities and the profile of cytokines they produce. The Th1 subset of CD4+ T cells secretes cytokines usually associated with inflammation, such as IFN-gamma and TNF and induces cell-mediated immune responses. The Th2 subset produces cytokines such as IL-4 and IL-5 that help B cells to proliferate and differentiate and is associated with humoral-type immune responses. The selective differentiation of either subset is established during priming and can be significantly influenced by a variety of factors. One of these factors, the cytokine environment, has been put forward as the major variable influencing Th development and is already well reviewed by others. Instead, in the current review, we focus on some of the alternative approaches for skewing Th1/Th2 responses. Specifically, we discuss the effects on Th priming of (a) using altered peptide ligands as antigens, (b) varying the dose of antigen, and (c) altering costimulatory signals. The potential importance of each of these variables to influence immune responses to pathogens in vivo is discussed throughout.
Micropattern gas detectors (2009)

An overview of Micropattern Gas Detectors is given. Recent progress of detector research, especially in the context of Micromegas and Gas Electron Multipliers, is discussed. A particular emphasis is put on the pixelized readout with a dedicated ASIC nameed Timepix, where new results with both gas amplification stages atop this chip are presented.
Regulation of CD8<sup>+</sup>regulatory T cells: Interruption of the NKG2A–Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease (2008)

Regulation of autoreactive CD4 T cells is essential to maintain self-tolerance and prevent autoimmune disease. Although CD8 T regulatory (Treg) cells that recognize self-peptides restricted by Qa-1 (HLA-E in humans) inhibit autoreactive CD4 cells and attenuate experimental autoimmune encephalomyelitis (EAE), the mechanism of this interaction is unclear. We generated Qa-1 mutant knock-in mice that impair Qa-1 binding to the T cell receptor (TCR) and CD94/NKG2A receptors. Analysis of these mice showed that TCR-dependent recognition of Qa-1-peptide complexes on target CD4 cells is essential for suppression by CD8 Treg cells. Further analysis revealed that genetic disruption of the Qa-1-CD94/NKG2A interaction unleashes robust CD8 Treg cell activity that completely abolishes development of EAE.
Tau reduction prevents disease in a mouse model of <scp>D</scp>ravet syndrome (2014)

Tau reduction may be of therapeutic benefit in Dravet syndrome and other intractable genetic epilepsies.
EKG abnormalities in children and adolescents with symptomatic temporal lobe epilepsy (2004)

Cardiovascular dysregulation is common during temporal lobe CPSs in children. These results confirm a right hemispheric lateralization of sympathetic cardiac control.
Multi-group diagnostic classification of high-dimensional data using differential scanning calorimetry plasma thermograms (2019)

The thermoanalytical technique differential scanning calorimetry (DSC) has been applied to characterize protein denaturation patterns (thermograms) in blood plasma samples and relate these to a subject's health status. The analysis and classification of thermograms is challenging because of the high-dimensionality of the dataset. There are various methods for group classification using high-dimensional data sets; however, the impact of using high-dimensional data sets for cancer classification has been poorly understood. In the present article, we proposed a statistical approach for data reduction and a parametric method (PM) for modeling of high-dimensional data sets for two- and three- group classification using DSC and demographic data. We compared the PM to the non-parametric classification method K-nearest neighbors (KNN) and the semi-parametric classification method KNN with dynamic time warping (DTW). We evaluated the performance of these methods for multiple two-group classifications: (i) normal versus cervical cancer, (ii) normal versus lung cancer, (iii) normal versus cancer (cervical + lung), (iv) lung cancer versus cervical cancer as well as for three-group classification: normal versus cervical cancer versus lung cancer. In general, performance for two-group classification was high whereas three-group classification was more challenging, with all three methods predicting normal samples more accurately than cancer samples. Moreover, specificity of the PM method was mostly higher or the same as KNN and DTW-KNN with lower sensitivity. The performance of KNN and DTW-KNN decreased with the inclusion of demographic data, whereas similar performance was observed for the PM which could be explained by the fact that the PM uses fewer parameters as compared to KNN and DTW-KNN methods and is thus less susceptible to the risk of overfitting. More importantly the accuracy of the PM can be increased by using a greater number of quantile data points and by the inclusion of additional demographic and clinical data, providing a substantial advantage over KNN and DTW-KNN methods.