gebhart/patrepeval huggingface dataset:
Coherence and Phase Sensitive Measurements in a Quantum Dot (1995)

Via a novel interference experiment, which measures magnitude and phase of the transmission coefficient through a quantum dot in the Coulomb regime, we prove directly, for the first time, that transport through the dot has a coherent component. We find the same phase of the transmission coefficient at successive Coulomb peaks, each representing a different number of electrons in the dot; however, as we scan through a single Coulomb peak we find an abrupt phase change of \ensuremath{\pi}. The observed behavior of the phase cannot be understood in the single particle framework.
Premature labor, Part I: Risk assessment, etiologic factors, and diagnosis. (1992)

Risk factors for preterm labor, which include items related to the pregnant woman's demographic characteristics, history, daily habits, and current pregnancy, have been combined into scoring systems commonly used by clinicians and researchers to single out women at risk for preterm delivery. When such systems are tested in obstetric populations, results show variable success in predicting preterm labor or birth. These inconsistent results could be due, in part, to important factors that have often been omitted from scoring systems, such as chemical abuse, poor nutrition, little social support, demanding work, multiple sexual partners, past or current sexually transmitted diseases, and other gynecologic infections. Women who are considered high risk for preterm labor can benefit from participating in preterm birth prevention programs that incorporate home monitoring, patient education regarding the signs and symptoms of preterm labor, frequent contacts with health professionals, and cervical examinations.
Stem cells in veterinary medicine (2011)

The stem cell field in veterinary medicine continues to evolve rapidly both experimentally and clinically. Stem cells are most commonly used in clinical veterinary medicine in therapeutic applications for the treatment of musculoskeletal injuries in horses and dogs. New technologies of assisted reproduction are being developed to apply the properties of spermatogonial stem cells to preserve endangered animal species. The same methods can be used to generate transgenic animals for production of pharmaceuticals or for use as biomedical models. Small and large animal species serve as valuable models for preclinical evaluation of stem cell applications in human beings and in veterinary patients in areas such as spinal cord injury and myocardial infarction. However, these applications have not been implemented in the clinical treatment of veterinary patients. Reviews on the use of animal models for stem cell research have been published recently. Therefore, in this review, animal model research will be reviewed only in the context of supporting the current clinical application of stem cells in veterinary medicine.
AT-101 or placebo (P) with docetaxel (D) in second-line NSCLC with gene signature biomarker development (2009)

3577 Background: AT-101 inhibits the Bcl-2 protein family (Bcl-2, Bcl-xL, Mcl-1, Bcl-W) with broad preclinical activity including synergy with D. Methods: We conducted a randomized, double-blind, P-controlled phase 2 study. Patients had received 1 prior chemotherapy regimen for advanced NSCLC. Patients received AT-101 (40 mg b.i.d. days 1–3) or P with D (75 mg/m 2 day 1) Q 21 days. Primary endpoint was progression-free survival (PFS) by independent review (IR). Secondary endpoints were overall survival (OS) and investigator determined PFS. 102 patients were planned for 70 events (80% power, HR 0.6, 1-sided alpha 0.1). A biomarker of AT-101 activity was developed by treating 55 NSCLC cell lines with AT-101 and using the corresponding gene expression data to identify a genomic predictor of sensitivity to AT-101. Results: 106 patients were randomized. Baseline factors were balanced. Median OS for patients on AT-101+D was 7.3 months versus 5.6 months for P + D arm (HR 0.60, p = 0.05). The median investigator determined PFS was 12.6 weeks and 10.7 weeks for AT-101+D and P+D arms respectively (HR 1.0, p = 0.49); IR is ongoing. Common adverse events were fatigue (18%), anemia (18%), and dyspnea (18%). Grade 1/2 headaches occurred more frequently in the AT-101 arm. Analysis of gene expression data by Bayesian regression revealed a robust 500 gene predictor of sensitivity to AT-101 that was cross validated in a leave one out analysis and in an independent cohort of 32 NSCLC cell lines. Validation of the predictor in patient samples from the trial is ongoing. Conclusions: In this phase II trial AT-101, an oral pan Bcl-2 family inhibitor, had favorable OS compared to placebo when combined with docetaxel in previously treated NSCLC and was well tolerated. A genomic predictor of AT-101 sensitivity is likely to enrich for responders and identify novel therapeutic combinations for future [Table: see text]
Efficient Implementation and Processing of a Real-Time Panorama Video Pipeline (2013)

High resolution, wide field of view video generated from multiple camera feeds has many use cases. However, processing the different steps of a panorama video pipeline in real-time is challenging due to the high data rates and the stringent requirements of timeliness. We use panorama video in a sport analysis system where video events must be generated in real-time. In this respect, we present a system for real-time panorama video generation from an array of low-cost CCD HD video cameras. We describe how we have implemented different components and evaluated alternatives. We also present performance results with and without co-processors like graphics processing units (GPUs), and we evaluate each individual component and show how the entire pipeline is able to run in real-time on commodity hardware.
Orthogonal-Blendshape-Based Editing System for Facial Motion Capture Data (2008)

The authors present a novel data-driven 3D facial motion capture data editing system using automated construction of an orthogonal blendshape face model and constrained weight propagation, aiming to bridge the popular facial motion capture technique and blendshape approach. In this work, a 3D facial-motion-capture-editing problem is transformed to a blendshape-animation-editing problem. Given a collected facial motion capture data set, we construct a truncated PCA space spanned by the greatest retained eigenvectors and a corresponding blendshape face model for each anatomical region of the human face. As such, modifying blendshape weights (PCA coefficients) is equivalent to editing their corresponding motion capture sequence. In addition, a constrained weight propagation technique allows animators to balance automation and flexible controls.
On the Radiation of Sound from an Unflanged Circular Pipe (1948)

A rigorous and explicit solution is obtained for the problem of sound radiation from an unflanged circular pipe, assuming axially symmetric excitation. The solution is valid throughout the wave-length range of dominant mode (plane wave) propagation in the pipe. The reflection coefficient for the velocity potential within the pipe and the power-gain function, embodying the characteristics of the radiation pattern, are evaluated numerically. The absorption cross section of the pipe for a plane wave incident from external space, and the gain function for this direction, are found to satisfy a reciprocity relation. In particular, the absorption cross section for normal incidence is just the area of the mouth. At low frequencies of vibration, the velocity potential within the pipe is the same as if the pipe were lengthened by a certain fraction of the radius and the open end behaved as a loop. The exact value of the end correction turns out to be 0.6133.
L'"entreprise État" et les discours sur la réforme des lois de finances (2003)

Forest Frédéric. L'"entreprise État" et les discours sur la réforme des lois de finances. In: Quaderni, n°53, Hiver 2003/2004. La convivialité, fable contemporaine. pp. 13-21.
The Gaussian wire-tap channel (1978)

Wyner's results for discrete memoryless wire-tap channels are extended to the Gaussian wire-tap channel. It is shown that the secrecy capacity Cs is the difference between the capacities of the main and wire.tap channels. It is further shown that Rd= Cs is the upper boundary of the achievable rate-equivocation region.
Discovery of Pyrazolo[1,5-<i>a</i>]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent (2016)

This work describes a scaffold hopping exercise that begins with known imidazo[1,2-a]pyrazines, briefly explores pyrazolo[1,5-a][1,3,5]triazines, and ultimately yields pyrazolo[1,5-a]pyrimidines as a novel class of potent TTK inhibitors. An X-ray structure of a representative compound is consistent with 1(1)/2 type inhibition and provides structural insight to aid subsequent optimization of in vitro activity and physicochemical and pharmacokinetic properties. Incorporation of polar moieties in the hydrophobic and solvent accessible regions modulates physicochemical properties while maintaining potency. Compounds with enhanced oral exposure were identified for xenograft studies. The work culminates in the identification of a potent (TTK K i = 0.1 nM), highly selective, orally bioavailable anticancer agent (CFI-402257) for IND enabling studies.
High Performance Micellar Liquid Chromatography with Silica Micro-Particles Having Surface-Bound Cationic Surfactant Moieties. I. Comparison with Octadecylsilica and Applications to the Separation of Dansyl Amino Acids, Herbicides, and Catecholamines (1995)

Abstract The usefulness of silica microparticles having surface-bound cationic surfactant ligands in reversed phase chromatography (RPC) and micellar liquid chromatography (MLC) was examined, and the influence of surfactant type on retention and separation selectivity was studied. Different selectivities were observed by using silica microparticles having surface-bound cationic surfactant ligands, such as noctadecyldimethyl(propylsilyl)ammonium groups (C18N+(Me)2Pr) when compared to a C18-silica column in the separation of dansyl amino acids (Dns-AA), herbicides and catecholamines by RPC and MLC. The presence of surface-bound charged moieties affected the amount of surfactant adsorbed onto the surface of the stationary phase from a given micellar mobile phase, which in turn influenced the retention behavior of neutral and charged species, thus leading to a unique chromatographic selectivity.
A High-Efficient CMOS RF Power Amplifier With Automatic Adaptive Bias Control (2006)

A 2.4-GHz Doherty power amplifier (PA) is developed in 0.18- <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$mu$</tex> m CMOS technology. An automatic adaptive bias control circuit is integrated with the auxiliary PA to improve the overall performance of the PA. Operated at 3V, the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$P_1 dB$</tex> and associated power-added-efficiency (PAE) of the PA are 21dBm and 33%, respectively. At the output power 6-dB backoff from <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$P_1 dB$</tex> , the PAE remains 21%. The limited PAE degradation at backoff power levels makes the PA suitable for the applications with high peak-to-average power ratio.
Integrated Sample Pretreatment System for N-Linked Glycosylation Site Profiling with Combination of Hydrophilic Interaction Chromatography and PNGase F Immobilized Enzymatic Reactor via a Strong Cation Exchange Precolumn (2011)

An integrated sample pretreatment system, composed of a click maltose hydrophilic interaction chromatography (HILIC) column, a strong cation exchange (SCX) precolumn, and a PNGase F immobilized enzymatic reactor (IMER), was established for the simultaneous glycopeptide enrichment, sample buffer exchange, and online deglycosylation, by which the sample pretreatment for glycoproteome could be performed online automatically, beneficial to improve the efficiency and sensitivity of the N-linked glycosylation site identification. With such a system, the deglycosylated glycopeptide from the digests of avidin with the coexistence of 50 times (mass ratio) BSA could be selectively detected, and the detection limit as low as 5 fmol was achieved. Moreover, the sample pretreatment time was significantly shortened to ~1 h. Such a system was further successfully applied for analyzing the digest of the soluble fraction extracted from rat brain. A total of 120 unique glycoprotein groups and 196 N-linked glycosylation sites were identified by nanoreversed phase liquid chromatography-electrospray ionization-tandem mass spectrometry (nanoRPLC-ESI-MS/MS), with the injected digests amount as 6 μg. All these results demonstrate that the integrated system is of great promise for N-linked glycosylation site profiling and could be further online coupled with nanoHPLC-ESI-MS/MS to achieve high-throughput glycoproteome analysis.
Paper-Based Sensor for Monitoring Sun Exposure (2016)

An easy to use and easy to fabricate sun exposure sensor was prepared via the inkjet printing of titanium dioxide (TiO2), polyvinylpyrrolidone (PVP), and food dye on paper. The sun exposure sensor works by employing titanium dioxide (TiO2) as a photocatalyst to degrade the food dyes resulting in gradual discoloration of this film. The PVP serves as a binder to allow film formation. The discoloration can be observed by the naked eye or quantitatively monitored using UV–vis reflectance spectra. Finally, discoloration of the films was calibrated to match UV exposure time of different skin types, by using different UV neutral density filters with the ability to transmit between 1.5% and 70% of the irradiant UV light from the sources to the photoactive film.
Efficient and Chirally Specific Synthesis of Phenanthro‐Indolizidine Alkaloids by Parham‐Type Cycloacylation (2009)

Abstract A concise, efficient and modular route involving Parham‐type cycloacylation as the key step has been used to synthesize six enantiopure phenanthro‐indolizidine alkaloids 1a – c . The preparation of enantiomerically pure tylophora alkaloids and their seco analogues on a large‐scale is now feasible. The alcohol intermediates 8a – c , which are difficult to prepare by other synthetic methodologies, have been synthesized by a metallation–cyclization–reduction sequence in excellent yields.
Status and future of GaN-based vertical-cavity surface-emitting lasers (2015)

Vertical-cavity surface-emitting lasers (VCSELs) offer distinct advantages over conventional edge-emitting lasers, including lower power consumption, single-longitudinal-mode operation, circularly symmetric output beams, waferlevel testing, and the ability to form densely packed, two-dimensional arrays. High-performance GaN-based VCSELs are well suited for applications in high-density optical data storage, high-resolution printing, lighting, displays, projectors, miniature atomic clocks, and chemical/biological sensing. Thus far, the performance of these devices has been limited by challenges associated with the formation of high-reflectance distributed Bragg reflectors (DBRs), optical mode confinement, carrier transport, lateral current spreading, polarization-related electric fields, and cavity-length control. This manuscript discusses the state-of-the-art results for electrically injected GaN-based VCSELs and reviews approaches to overcome the key challenges currently preventing higher performance devices. The manuscript also describes the development of nonpolar GaN-based VCSELs on free-standing GaN. Nonpolar orientations exhibit anisotropic optical gain within the quantum well plane and uniquely enable VCSELs with a well-defined and stable polarization state. In addition, a detailed description of a band-gap-selective photoelectrochemical etching (BGS PECE) process for substrate removal and fine cavity length control on free-standing GaN substrates is provided.
Allylic Amination and 1,2‐Diamination with a Modified Diimidoselenium Reagent (1996)

Replacing the tosyl with a nosyl (Ns) group—that is the key to an improved method for both allylic amination of olefins and 1,2-diamination of 1,3-dienes. The protecting group recently introduced by Fukuyama et al., the 0-nitrobenzenesulfonyl (nosyl) group, can be employed with diimidoselenium reagents. The resulting nosyl-amides can be converted into primary and secondary amines in good to excellent yields. An example of this approach is sketched below in reaction (a) (R  Me, CH2CHCH2, CH2Ph).
Concurrent D-algorithm on reconfigurable hardware (1999)

In this paper, a new approach for generating test vectors that detects faults in combinational circuits is introduced. The approach is based on automatically designing a circuit which implements the D-algorithm, an automatic test pattern generation (ATPG) algorithm, specialized for the combinational circuit. Our approach exploits fine-grain parallelism by performing the following in three clock cycles: direct backward/forward implications, conflict checking, selecting next gate to propagate fault or to justify a line, decisions on gate inputs, loading the state of the circuit after backup. In this paper, we show the feasibility of this approach in terms of speed, and how it compares with software based techniques.
Colorimetric Detection of Dengue by Single Tube Reverse-Transcription-Loop-Mediated Isothermal Amplification (2015)

Dengue is usually diagnosed by isolation of the virus, serology or molecular diagnostic methods. Several commercial kits for the diagnosis of dengue are existing, but concerns have arisen regarding to the affordability and performance characteristics of these kits. Hence, the loop-mediated isothermal amplification (LAMP) is potentially ideal to be used especially in resource limited environments. Serum was collected from healthy donors and patients diagnosed with dengue infection. RNA extracted from the serum samples were tested by reverse-transcription-LAMP assay developed based on 3'-NCR gene sequences for DENV 1-4. Results were interpreted by a turbidity meter in real time or visually at the end of the assay. Sensitivity and specificity of RT-LAMP results were calculated and compared to qRT-PCR and ELISA. RT-LAMP is highly sensitive with the detection limit of 10 RNA copies for all serotypes. Dengue virus RNA was detected in all positive samples using RT-LAMP and none of the negative samples within 30-45 minutes. With continuing efforts in the optimization of this assay, RT-LAMP may provide a simple and reliable test for detecting DENV in areas where dengue is prevalent.
Isotactic polymerization of propene: stereoregularity of the insertion of the first monomer unit as a fingerprint of the catalytic active site (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsotactic polymerization of propene: stereoregularity of the insertion of the first monomer unit as a fingerprint of the catalytic active siteAdolfo Zambelli, Paolo Locatelli, Maria Carmela Sacchi, and I. TrittoCite this: Macromolecules 1982, 15, 3, 831–834Publication Date (Print):May 1, 1982Publication History Published online1 May 2002Published inissue 1 May 1982https://doi.org/10.1021/ma00231a027RIGHTS & PERMISSIONSArticle Views102Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (479 KB) Get e-Alerts Get e-Alerts
Passive Sensing of Driver Intoxication (2006)

<div class="htmlview paragraph">A sensor that passively monitors the driver for intoxication has been demonstrated. The driver's blood alcohol concentration (BAC) is obtained by sensing alcohol and CO<sub>2</sub> in air drawn from the vehicle cabin. With a legally drunk driver, the steady state alcohol concentration can be as low as 0.3 ppm, even with the doors and windows closed. The sensor uses infrared transmission to quantify alcohol vapor and CO<sub>2</sub>. A vapor concentrator increases alcohol sensitivity - an adsorber collects alcohol vapor and releases it as a concentrated burst at 1 minute intervals. A valid measure of driver BAC is ordinarily available 1.5 minutes after the driver gets in. Sensed CO<sub>2</sub> must be above a threshold for a valid measurement.</div>
Performance of Field Emission Cathodes in Xenon Electric Propulsion System Environments (2000)

Colleen M. Marrese* and James E. polkt Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California Kevin L. ens en* Naval Research Laboratory, Washington, D.C. Alec D. ~al l imorel University of Michigan, Ann Arbol; Michigan Capp A. spindt SRI International, Palo Alto, California Richard L. ink** Field Emission Picture Element Technology, Austin, Texas and W. Devereux palmertt Microelectronics Center of North Carolina, Research Triangle Park, North Carolina
Validity of an adaptation of the Framingham cardiovascular risk function: the VERIFICA study (2006)

The Framingham function adapted to local population characteristics accurately and reliably predicted the 5-year CHD risk for patients aged 35-74 years, in contrast with the original function, which consistently overestimated the actual risk.
How to extract maximum information from event-driven topology updates (2002)

Link-state updating in communication networks undergoing topological changes is addressed. It is concluded that the best way of disseminating link-state information is through event-driven (ED) updating, and it is shown how to overcome the traditional drawbacks of ED updating. An efficient algorithm that extracts the maximum implicit information from ED topology updates by computing the latest time for which each processing node can be certain of the state of each network link is given. It is shown that the information obtained is equivalent to that obtained by continuous flooding of link-state information. A method that allows each node to refresh the above information continuously without running the algorithm more than once for each received update is presented, as is an approximate version of the algorithm that reduces communication overhead by limiting the radii of propagation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The CTCF Insulator Protein Is Posttranslationally Modified by SUMO (2008)

The CTCF protein is a highly conserved zinc finger protein that is implicated in many aspects of gene regulation and nuclear organization. Its functions include the ability to act as a repressor of genes, including the c-myc oncogene. In this paper, we show that the CTCF protein can be posttranslationally modified by the small ubiquitin-like protein SUMO. CTCF is SUMOylated both in vivo and in vitro, and we identify two major sites of SUMOylation in the protein. The posttranslational modification of CTCF by the SUMO proteins does not affect its ability to bind to DNA in vitro. SUMOylation of CTCF contributes to the repressive function of CTCF on the c-myc P2 promoter. We also found that CTCF and the repressive Polycomb protein, Pc2, are colocalized to nuclear Polycomb bodies. The Pc2 protein may act as a SUMO E3 ligase for CTCF, strongly enhancing its modification by SUMO 2 and 3. These studies expand the repertoire of posttranslational modifications of CTCF and suggest roles for such modifications in its regulation of epigenetic states.