gebhart/patrepeval huggingface dataset:
Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window (2016)

Altogether, this review suggests a therapeutic window for mGluR5 NAMs that can be translated to the treatment of substance-related and addictive disorders.
Atlas of the spectrum of a platinum neon hollow-cathode reference lamp in the region 1130-4330 angstrom (1992)

The spectrum of a platinum hollowcathode lamp containing neon carrier gas was recorded photographically and photoelectrically with a 10.7 m normalincidence vacuum spectrograph. Wavelengths and intensities were determined for about 5600 lines in the region 1130-4330 A. An atlas of the spectrum is given, with the spectral lines marked and their intensities, wavelengths, and classifications listed. Lines of impurity species are also identified. The uncertainty of the photographically measured wavelengths is estimated to be 0.0020 A. The uncertainty of lines measured in the photoelectric scans is 0.01 A for wavelengths shorter than 2030 A and 0.02 A for longer wavelengths. Ritz-type wavelengths are given for many of the classified lines of Pt II with uncertainties varying from 0.0004 to 0.0025 A. The uncertainty of the relative intensities is estimated to be about 20%.
TGA1 and G-box binding factors: two distinct classes of Arabidopsis leucine zipper proteins compete for the G-box-like element TGACGTGG. (1992)

Regulatory elements containing the sequence ACGT are found in several plant promoters and are recognized by various basic/leucine zipper (bZIP) proteins. The Arabidopsis G-box binding factor 1 (GBF1), initially identified by its ability to bind to the palindromic G-box (CCACGTGG), also interacts with the TGACGT motif if this hexamer sequence is followed by either the dinucleotide GG--as found in the Hex motif of the wheat histone 3 promoter--or GT. Here we describe the isolation of an Arabidopsis bZIP protein, denoted TGA1, that also recognizes ACGT-containing sequences. However, TGA1 differs from members of the GBF family in the spectrum of base pair permutations flanking the ACGT sequence that are required for DNA binding. TGA1 primarily requires a TGACG motif and preferentially binds to those pentamers that are followed by a T residue. We show that although both TGA1 and GBF1 bind to the Hex motif (TGACGTGG), this binding can be distinguished on the basis of their specific DNA-protein contacts. Furthermore, TGA1 also differs from members of the GBF family in that it apparently does not form heterodimers with any member of this family.
A cognitive classification framework for 3-dimensional information visualization (1998)

ion: how does the design support information structuring and information hiding? ffl Affordances: how does the design show the users what they can do with it? The rest of this paper is divided into four sections. Section 2 discusses the three cognitive aspects used to classify 3D information visualization designs. In Section 3, fifteen important designs are described and compared using the three cognitive aspects, and Section 4 discusses some recent work in information visualization classification. The final section (Section 5) contains a discussion of 3D information visualization designs based on the comparisons in the paper. 2 Cognitive Aspects The ultimate purpose of any information visualization is to communicate properties of the information to a human. Therefore, it is important to consider human cognition when classifying information visualization designs. This report discusses cognitive aspects related to 3D information visualization, but the framework can easily be used for...
Sludge Compaction with Ash (2006)

Mixing pulp mill primary sludge from the clarifier underflow with an ash sluice stream from the bark boiler reduced the resistance to dewatering the sludge. The sludge compacted better and increased the capacity of a holding pond, which led to substantial cost savings. Similar results were obtained with mixing ash with activated sludge. Ash particles that bear a positive zeta potential neutralize the negatively charged sludge, increase the degree of agglomeration and reduce the sludge volume. No compaction occurs with negatively charged ash unless the charge on the ash is reversed, e.g. through addition of calcium.
Injection locking of microwave solid-state oscillators (1973)

Injection locking of microwave solid-state oscillators is discussed, based on the familiar theorem that the total impedance times the current is equal to the applied voltage. Both quasi-static and dynamic analyses of the locking range, large-signal injection, locking stability, and AM and FM noise are given, and recent experimental work is reviewed briefly. No applications of injection locking are discussed in detail.
Identification of a Mouse Homolog of the Human <i>BTEB2</i> Transcription Factor as a β-Catenin-Independent Wnt-1-Responsive Gene (2001)

The Wnt/Wg signaling pathway functions during development to regulate cell fate determination and patterning in various organisms. Two pathways are reported to lie downstream of Wnt signaling in vertebrates. The canonical pathway relies on the activation of target genes through the beta-catenin-Lef/TCF complex, while the noncanonical pathway employs the activation of protein kinase C (PKC) and increases in intracellular calcium to induce target gene expression. cDNA subtractive hybridization between a cell line that overexpresses Wnt-1 (C57MG/Wnt-1) and the parental cell line (C57MG) was performed to identify downstream target genes of Wnt-1 signaling. Among the putative Wnt-1 target genes, we have identified a mouse homolog of the gene encoding human transcription factor basic transcription element binding protein 2 (mBTEB2). The mBTEB2 transcript is found at high levels in mammary tissue taken from a transgenic mouse overexpressing Wnt-1 (both tissue prior to active proliferation and tumor tissue) but is barely detectable in wild-type mouse mammary glands. The regulation of mBTEB2 by Wnt-1 signaling in tissue culture occurs through a beta-catenin-Lef/TCF-independent mechanism, as it is instead partially regulated by PKC. The Wnt-1-induced, PKC-dependent activation of mouse BTEB2 in C57MG cells, as well as the ability of Wnt-1 to stabilize beta-catenin in these cells, is consistent with the hypothesis that both the noncanonical and canonical Wnt pathways are activated concomitantly in the same cell. These results suggest that mBTEB2 is a biologically relevant target of Wnt-1 signaling that is activated through a beta-catenin-independent, PKC-sensitive pathway in response to Wnt-1.
Combined 633-nm and 830-nm led treatment of photoaging skin. (2006)

633-nm and 830-nm LED treatments play a role in the treatment of photodamaged skin. LED treatments can be used as either a primary or adjunctive treatment modality.
ChemInform Abstract: Digitalis: Its Mode of Action, Receptor, and Structure‐Activity Relationships (1990)

ChemInformVolume 21, Issue 43 Reviews ChemInform Abstract: Digitalis: Its Mode of Action, Receptor, and Structure-Activity Relationships R. THOMAS, R. THOMAS Dep. Pharm., Univ., Sydney, AustraliaSearch for more papers by this authorP. GRAY, P. GRAY Dep. Pharm., Univ., Sydney, AustraliaSearch for more papers by this authorJ. ANDREWS, J. ANDREWS Dep. Pharm., Univ., Sydney, AustraliaSearch for more papers by this author R. THOMAS, R. THOMAS Dep. Pharm., Univ., Sydney, AustraliaSearch for more papers by this authorP. GRAY, P. GRAY Dep. Pharm., Univ., Sydney, AustraliaSearch for more papers by this authorJ. ANDREWS, J. ANDREWS Dep. Pharm., Univ., Sydney, AustraliaSearch for more papers by this author First published: October 23, 1990 https://doi.org/10.1002/chin.199043336Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume21, Issue43October 23, 1990 RelatedInformation
The Science and Engineering of Materials, SI Edition (2011)

The Science and Engineering of Materials Sixth Edition describes the foundations and applications of materials science as predicated upon the structure-processing-properties paradigm with the goal of providing enough science so that the reader may understand basic materials phenomena, and enough engineering to prepare a wide range of students for competent professional practice. By selecting the appropriate topics from the wealth of material provided in The Science and Engineering of Materials, instructors can emphasize materials, provide a general overview, concentrate on mechanical behavior, or focus on physical properties. Since the book has more material than is needed for a one-semester course, students will also have a useful reference for subsequent courses in manufacturing, materials, design, or materials selection.
Nonlinear Optical Processes and DUV Generation in Random Domain Structures of SBO (2015)

Random domain structures in orthorhombic strontium tetraborate (α-SBO) are capable in enhancing nonlinear optical conversion efficiency for large variety of processes throughout all transparency window of this material, down to 121 nm. Properties of the material, origin of domains, frequency doubling and autocorrelation measurements, conversion of supercontinuum to UV and continuously tunable VUV generation are described. Prospects of biphoton field generation in α-SBO are discussed.
Structural Interactions between Horseradish Peroxidase C and the Substrate Benzhydroxamic Acid Determined by X-ray Crystallography<sup>,</sup> (1998)

The three-dimensional structure of recombinant horseradish peroxidase in complex with BHA (benzhydroxamic acid) is the first structure of a peroxidase-substrate complex demonstrating the existence of an aromatic binding pocket. The crystal structure of the peroxidase-substrate complex has been determined to 2.0 A resolution with a crystallographic R-factor of 0.176 (R-free = 0. 192). A well-defined electron density for BHA is observed in the peroxidase active site, with a hydrophobic pocket surrounding the aromatic ring of the substrate. The hydrophobic pocket is provided by residues H42, F68, G69, A140, P141, and F179 and heme C18, C18-methyl, and C20, with the shortest distance (3.7 A) found between heme C18-methyl and BHA C63. Very little structural rearrangement is seen in the heme crevice in response to substrate binding. F68 moves to form a lid on the hydrophobic pocket, and the distal water molecule moves 0.6 A toward the heme iron. The bound BHA molecule forms an extensive hydrogen bonding network with H42, R38, P139, and the distal water molecule 2.6 A above the heme iron. This remarkably good match in hydrogen bond requirements between the catalytic residues of HRPC and BHA makes the extended interaction between BHA and the distal heme crevice of HRPC possible. Indeed, the ability of BHA to bind to peroxidases, which lack a peripheral hydrophobic pocket, suggests that BHA is a general counterpart for the conserved hydrogen bond donors and acceptors of the distal catalytic site. The closest aromatic residue to BHA is F179, which we predict provides an important hydrophobic interaction with more typical peroxidase substrates.
An Ethical Analysis of Pharmacy Benefit Manager (PBM) Practices (2019)

The high costs associated with pharmaceuticals and the accompanying stakeholders are being closely evaluated in the search for solutions. As a major stakeholder in the U.S. pharmaceutical market, the practices of pharmacy benefit manager (PBM) organizations have been under increased scrutiny. Examples of controversial practices have included incentives driving formulary status and prohibiting pharmacists from disclosing information on lower-cost prescription alternatives. Ethical investigations have been largely omitted within the debate on the responsibilities of these organizations in the health care system. Ethical analysis of organizational practices is justified based on the potential impact during health care delivery. The objective of this study was to analyze several specific PBM practices using multiple ethical decision-making models to determine their ethical nature. This study systematically applied multiple ethical decision-making models and codes of ethics to a variety of practices associated with PBM-related dilemmas encountered in the pharmaceutical environment. The assessed scenarios resulted in mixed outcomes. PBM practices were both ethical and unethical depending on the applied ethical model. Despite variation across applied models, some practices were predominately ethical or unethical. The point of sale rebates were consistently determined as ethical, whereas market consolidation, gag clauses, and fluctuation of pharmacy reimbursements were all predominantly determined as unethical. The application of using provider codes of ethics created additional comparison and also contained mixed findings. This study provided a unique assessment of PBM practices and provides context from a variety of ethical perspectives. To the knowledge of the authors, these perspectives have not been previously applied to PBM practices in the literature. The application of ethical decision-making models offers a unique context to current health care dilemmas. It is important to analyze health care dilemmas using ethics-based frameworks to contribute solutions addressing complexities and values of all stakeholders in the health care environment.
Security of NFC applications (2013)

Near Field Communication (NFC) refers to a communication technology that enables an effortless connection and data transfers between two devices by putting them in a close proximity. Besides contac ...
Java implementation of policy‐based bandwidth management (2003)

Abstract We describe a Java implementation of a policy based bandwidth management system using the standard policy protocols and an interface to the Linux Diffserv implementation. The useful features, such as extensibility and object orientation, of the Java implementation is illustrated by directly referring to the relevant programming codes. Through two practical experiments, we demonstrate the capability of our implementation in supporting policy‐based dynamic resource allocations in enterprise networks. Copyright © 2003 John Wiley &Sons, Ltd.
High gain ultraviolet photodetectors based on AlGaN/GaN heterostructures for optical switching (2011)

We report on the optoelectronic properties of Al0.25Ga0.75N/GaN-based ultraviolet (UV) photodetectors for the application as a high current, high gain optical switch. Due to an internal gain mechanism combined with the high conductivity of the two-dimensional electron gas at the heterostructure interface, photocurrents in the milliampere-range were obtained with UV illumination. By employing a mesa structure design with meander geometry very low dark currents below 50 nA up to a bias voltage of 100 V were achieved. Optical switching with an on/off-current-ratio of five orders of magnitude was demonstrated. The response time was determined to be 6 ms and persistent photoconductivity was observed. The photodetector is visible-blind with a cut-off wavelength of 365 nm according to the band gap energy of the GaN absorption layer. A high responsivity with a maximum of 70 A/mW at 312 nm and 100 V bias voltage was demonstrated.
Towards a generic architecture for mobile object-oriented applications (2002)

Our previous work in mobility support for CORBA applications resulted in the design and implementation of the Architecture for Location-Independent CORBA Environments (ALICE). The first version of ALICE enabled CORBA objects running on mobile devices to interact transparently with objects hosted by off-the-shelf CORBA implementations without relying on a centralised location register to keep track of their whereabouts. This paper presents the second version of ALICE on which work is ongoing. The improved architecture retains the features of the original and adds support for disconnected operation in the form of caching of server functionality on the client side. Furthermore, the architecture is being generalised beyond CORBA in order to make it applicable to other distribution infrastructures, such as Java RMI and DCOM.
Carbon-carbon heat pipe testing and elevation (1994)

This report discusses development and proof-of-concept testing of a new lightweight carbon-carbon (C-C) space radiator heat pipe developed under the NASA Civil Space Technology Initiative (CSTI) High Capacity Power Program. The heat pipe was filled with potassium working fluid and tested for 11 hours including startup from ambient temperature with the working fluid initially in the frozen state to near 700 K condenser temperature. Steady-state heat pipe input power during testing was facility limited to about 300 watts, representing about 50 percent of the design input power. Post test inspection showed the heat pipe to be in excellent condition after eight thermal cycles from ambient to steady-state operating temperature. Potential applications, ranging from small spacecraft heat rejection to aircraft and terrestrial uses, are discussed.
Changes in phospholipid metabolism during B lymphocyte activation. (1986)

We have examined phospholipid metabolism in murine B lymphocytes stimulated with anti-Ig bound to Sepharose. T cell-depleted splenic B lymphocytes cultured with Sepharose-coupled, affinity-purified goat anti-mouse Ig (GAMIg) increased the incorporation of 32PO4 into phosphatidic acid and phosphatidylinositol within 3 hr and increased [3H]-thymidine uptake at 48 hr. No increase in labeling was observed in phosphatidylethanolamine, phosphatidylcholine, or phosphatidylserine. Based on both negative and positive selection procedures, it was demonstrated that these responses occurred in B lymphocytes. In contrast to the thymidine uptake response of the GAMIg-stimulated B lymphocytes, the phospholipid response did not require the presence of accessory cells or exogenous cytokines. The same selective changes in phospholipid metabolism were observed in neoplastic B lymphocytes (BCL1) after treatment with Sepharose anti-mu, but not with Sepharose anti-Ia or Sepharose normal Ig. The dose-response relationships of 32PO4 incorporation into phosphatidic acid and phosphatidylinositol and [3H] thymidine uptake were nearly identical in BCL1 cells. The results of these experiments indicate that interaction of B lymphocytes with insolubilized anti-Ig results in prompt and selective changes in phospholipid metabolism that appear to be correlated with B lymphocyte proliferation.
Nonvariational numerical calculations of excitonic properties in quantum wells in the presence of strain, electric fields, and free carriers (1990)

In this paper we describe the properties of effective-mass excitons in quantum wells in the presence of strain, transverse electric fields, and free carriers using a nonvariational numerical technique. The technique allows us to avoid the use of a prechosen form for the excitonic wave function and can be applied to arbitrarily shaped quantum wells with external perturbations. We describe the valence band within the effective-mass approximation using a 4\ifmmode\times\else\texttimes\fi{}4 k\ensuremath{\cdot}p Hamiltonian which neglects the split-off band; the conduction band is assumed to be parabolic. Results are presented for exciton binding energies, wave functions, and oscillator strengths.
Polysiloxane Super-Toughening of Silica Gas Barrier Coatings on Polymer Substrates (2009)

Oxygen barrier performances and mechanical properties of SiOx coatings deposited on PET films by PECVD have been improved by the application of ultra-thin (10-500 nm) UV-polymerized silane compounds layers. Depending on the processing conditions, oxygen transmission rates of silane treated SiOx/ PET barrier films were measured to be twice better than witness samples, and the coating strains to failure of treated SiOx were improved from 1.5% to 5.0%. Such huge improvement in mechanical property of the silane/silica barrier coating, with a toughness as high as 80 J/m 2 , was found to be controlled by the conversion state of the silane layer with influence of temperature, UV-light intensity and photo-initiator concentration.
Master-slave control based reliable micro-Grid with back-to-back voltage source converter as master DG (2017)

Reliable and eco-friendly power demand at consumer load end leads to integration of local distributed generation (DG) based micro-grids in the electricity network. Adequate local load sharing between the DG's in the micro-grids is necessary in islanded mode under faulty grid condition. This paper presents a grid connected micro-grid system with a back-to-back voltage source converter (VSC) based DG and single VSC's based DG's. The transition from grid connected to islanded mode under faulty grid condition is presented. A master-slave load sharing control method is developed for a micro-grid in islanded mode under faulty grid condition, in which a back-to-back VSC acts as a master DG and remaining as slave DG's. This control method regulates the DC-link voltage of master DG when its DC input power is unavailable in order to overcome the micro-grid shutdown. The transient performance of the proposed micro-grid in islanded mode under load variation, failure of slave DG and unavailability of DC input power to master DG is demonstrated. The overall performance of the proposed micro-grid under both grid connected and islanded mode is verified using MATLAB simulation and OPAL-RT real time simulator.
Capsular K1 polysaccharide of Escherichia coli: relationship to virulence in newborn rats and resistance to phagocytosis (1979)

The virulence of Escherichia coli strains for newborn rats was related to opsonic requirements of the strains, sensitivity to the bactericidal activity of serum, and K1 capsular polysaccharide content. K1 E. coli strains were more virulent than non-K1 strains after intraperitoneal injection in newborn rats (P less than 0.05) and were more resistant to phagocytosis than non-K1 strains when the classical complement pathway was blocked with Mg-ethyleneglycoltetraacetic acid (P less than 0.0005). Sensitivity to the bactericidal activity of serum was similar among K1 and non-K1 E. coli strains. Two groups of K1 E. coli strains were defined on the basis of opsonic requirements. Group I strains were efficiently opsonized by the alternative complement pathway, while group II strains required the classical complement pathway for opsonization. Group I strains had less detectable K1 polysaccharide in the washed whole cell fraction than group II strains (10.3 versus 18.9 microgram of K1 polysaccharide per 10(10) colony-forming units) and were less virulent than group II strains (mortality, 44 versus 77%, P less than 0.05). The K1 capsular polysaccharide appears to play an important role in determining virulence in newborn rats and opsonic requirements of these strains, but does not contribute to the sensitivity of strains to the bactericidal activity of serum.