gebhart/patrepeval huggingface dataset:
The Emergence of Sociopolitical Complexity at Gournia: Local and Regional Perspectives (2012)

Between 2200 and 1900 B.C.E., the coastal site of Gournia on Crete grew substantially in size and population, eventually emerging as a regional center for production and export. At the same time, other sites in the Mirabello region were destroyed, and new sites were established in defensible locations. People from the Cycladic islands fled to Crete and established new settlements on the north coast, possibly in response to a climatic upheaval. How did Gournia manage to emerge as a prosperous center, amidst the turmoil and chaos sweeping through the Mirabello region at this time? This article proposes that by successfully integrating immigrant populations into a new lower class, elites at Gournia reorganized craft production, which fueled economic prosperity. Recent excavations at Gournia support this hypothesis. There is new evidence for intensive ceramic production at the northern periphery of the site in the Late Prepalatial period. In the Protopalatial period, an expansive new architectural complex with craft workshops was constructed near an elaborate residence, suggesting that elites played an important role in the centralization of production and redistribution at Gournia.
Wavelength-selective true time delay for optical control of phased-array antenna (2000)

Performance of an optically controlled phased-array antenna system employing novel single-chip optical wavelength selective true time-delay devices is reported. High-resolution time-delays are demonstrated using integrated delay lines. Extension to two-dimensional (2-D) antenna arrays with independent control of azimuth and elevation by using mid-stage optical wavelength conversion is proposed and demonstrated. An optical true-time-delay steered two-element X-band antenna was assembled to verify the wide instantaneous bandwidth operation.
Blue light-emitting diode fabrication of an InGaN/GaN epilayer bonded on a Si substrate by laser liftoff (2002)

We report that a blue LED was successfully fabricated oil a bounded InGaN/GaN/Si wafer, in which the InGaN/GaN epilayer was originally grown on a sapphire substrate then bonded and transferred to a Si substrate by laser liftoff technique.
Question-Answering Using Semantic Relation Triples. (1999)

This paper describes the development of a prototype system to answer questions by selecting sentences from the documents in which the answers occur. After parsing each sentence in these documents, databases are constructed by extracting relational triples from the parse output. The triples consist of discourse entities, semantic relations, and the governing words to which the entities are bound in the sentence. Database triples are also generated for the questions. Question-answering consists of matching the question database records with the records for the documents. The prototype system was developed specifically to respond to the TREC-8 Q&amp;A track, with an existing parser and some existing capability for analyzing parse output. The system was designed to investigate the viability of using structural information about the sentences in a document to answer questions. The CL Research system achieved an overall score of 0.281 (i.e., on average, providing a sentence containing a correct...
VLSI based analog power system emulator for fast contingency analysis (2004)

This paper is concerned with the development of a fast, programmable, and reconfigurable power system emulator using an analog/mixed-signal VLSI microchip. The proposed microchip is capable of emulating behaviors of large power system networks under various conditions with faster than real-time computation time that is independent of the size of the power system network. The proposed model focuses on static security analysis, where the main objective is to access the existing operating state of the system. If the state is found to be secure, contingency analysis is performed to evaluate system vulnerability and time necessary to obtain such results. This time is compared to traditional computational techniques to evaluate static security of a power system. This paper discusses the design methodology of the proposed microchip and describes a smaller scale prototype of the analog emulator that is currently being developed on printed circuit boards (PCBs).
Stratified phase II trial to establish the usefulness of the collagen gel droplet embedded culture-drug sensitivity test (CD-DST) for advanced gastric cancer (2013)

CD-DST predicts the outcome of patients undergoing chemotherapy for advanced gastric cancer, presumably through evaluating chemosensitivity.
Autoantibodies against type XVII collagen C-terminal domain in a patient with bullous pemphigoid associated with psoriasis vulgaris (2008)

Journal Article Autoantibodies against type XVII collagen C‐terminal domain in a patient with bullous pemphigoid associated with psoriasis vulgaris Get access D. Inokuma, D. Inokuma Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kita‐ku, Sapporo 060‐8638, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Kodama, K. Kodama Sapporo Railway Hospital, Sapporo, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Natsuga, K. Natsuga Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kita‐ku, Sapporo 060‐8638, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Kasai, M. Kasai Sapporo Railway Hospital, Sapporo, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Abe, M. Abe Sapporo Railway Hospital, Sapporo, Japan Search for other works by this author on: Oxford Academic Google Scholar W. Nishie, W. Nishie Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kita‐ku, Sapporo 060‐8638, Japan Search for other works by this author on: Oxford Academic Google Scholar R. Abe, R. Abe Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kita‐ku, Sapporo 060‐8638, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Hashimoto, T. Hashimoto Department of Dermatology, Kurume University School of Medicine, Kurume, Japan E‐mail: inokuma@med.hokudai.ac.jp Search for other works by this author on: Oxford Academic Google Scholar H. Shimizu H. Shimizu Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kita‐ku, Sapporo 060‐8638, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 2, 1 February 2009, Pages 451–454, https://doi.org/10.1111/j.1365-2133.2008.08961.x Published: 01 February 2009
Learning, extracting, inserting and verifying grammatical information in recurrent neural networks (1993)

Recurrent neural networks can be trained from string examples to behave like deterministic finite-state automata (DFA's) and pushdown automata (adapts) i.e. they recognize respectively deterministic regular and context-free grammars (DCFG's). The author discusses some of the successes and failures of this type of 'recurrent neural network' grammatical inference engine, as well as some of the issues of effectively using a priori symbolic knowledge in training dynamic networks. The author presents a method for networks with second-order weights where inserting prior knowledge into a network becomes a straight-forward mapping (or programming) of grammatical rules into weights. A more sophisticated hybrid machine was also developed, denoted as a neural network pushdown automata (NNPDA)-a recurrent net connected to a stack memory. This NNPDA learns to operate an external stack and recognize simple DCFG's from string examples. When hints about the grammars are given during training, the NNPDA is capable of learning more sophisticated DCFG's. >
The pharmacokinetics and metabolic disposition of tacrolimus: A comparison across ethnic groups (2001)

Significant differences in tacrolimus pharmacokinetics exist among the three different ethnic groups. Our results indicate that this may result from differences in intestinal CYP3A or P-glycoprotein activities.
Molecular Determinants of Vectofusin-1 and Its Derivatives for the Enhancement of Lentivirally Mediated Gene Transfer into Hematopoietic Stem/Progenitor Cells (2015)

Gene delivery into hCD34+ hematopoietic stem/progenitor cells (HSPCs) using human immunodeficiency virus, type 1-derived lentiviral vectors (LVs) has several promising therapeutic applications. Numerous clinical trials are currently underway. However, the efficiency, safety, and cost of LV gene therapy could be ameliorated by enhancing target cell transduction levels and reducing the amount of LV used on the cells. Several transduction enhancers already exist, such as fibronectin fragments or cationic compounds. Recently, we discovered Vectofusin-1, a new transduction enhancer, also called LAH4-A4, a short histidine-rich amphipathic peptide derived from the LAH4 family of DNA transfection agents. Vectofusin-1 enhances the infectivity of lentiviral and γ-retroviral vectors pseudotyped with various envelope glycoproteins. In this study, we compared a family of Vectofusin-1 isomers and showed that Vectofusin-1 remains the lead peptide for HSPC transduction enhancement with LVs pseudotyped with vesicular stomatitis virus glycoproteins and also with modified gibbon ape leukemia virus glycoproteins. By comparing the capacity of numerous Vectofusin-1 variants to promote the modified gibbon ape leukemia virus glycoprotein-pseudotyped lentiviral vector infectivity of HSPCs, the lysine residues on the N-terminal extremity of Vectofusin-1, a hydrophilic angle of 140° formed by the histidine residues in the Schiffer-Edmundson helical wheel representation, hydrophobic residues consisting of leucine were all found to be essential and helped to define a minimal active sequence. The data also show that the critical determinants necessary for lentiviral transduction enhancement are partially different from those necessary for efficient antibiotic or DNA transfection activity of LAH4 derivatives. In conclusion, these results help to decipher the action mechanism of Vectofusin-1 in the context of hCD34+ cell-based gene therapy.
Derivatized cardo-polyetherketone anion exchange membranes for all-vanadium redox flow batteries (2014)

The stability of cardo-poly(etherketone) based anion exchange membranes was investigated by performing 1-D and 2-D HMQC NMR spectroscopy.
Expression patterns of the E2F family of transcription factors during murine epithelial development. (1997)

The E2F family of transcription factors includes five E2F and three DP forms. E2F is involved in the regulation of cell proliferation, but little is known about E2F function during vertebrate development. We have explored the regulation of E2F expression during mouse organogenesis by in situ hybridization. We find selective up-regulation of E2F-2, E2F-4, and E2F-5 transcripts in epidermis and intestinal epithelium at important developmental stages. E2F-4 transcript levels are high in early, undifferentiated single-cell-layer ectoderm, and later in 13.5-14.5-day-postcoitus (dpc) embryo epithelium, which contains several layers of proliferating cells. E2F-2 is up-regulated following the onset of E2F-4 expression and is first apparent in undifferentiated epithelium at 13.5-14.5 days of gestation. In contrast, E2F-5 transcripts are detected later in gestation, once the epidermis shows evidence of stratification. Stratification of the epidermis into basal, proliferating cells and suprabasal, terminally differentiating cells at 15.5-19.5 days of gestation coincides with expression of E2F-2 and E2F-4 in basal cells and of E2F-5 in suprabasal cells. Similarly, in intestinal epithelium, E2F-4 up-regulation in pseudostratified epithelium at 13.5 days of gestation precedes appearance of E2F-2 transcripts, in 14.5-dpc embryos, in the proliferating, intervillus epithelium. In 16.5-19.5-dpc embryos, no E2F-2 transcripts were detected at the tip of the developing villi, which contain terminally differentiating cells. In contrast, E2F-5 transcripts were limited to the upper half of the villi and were absent in the intervillus epithelium. This suggests that E2F-2 and E2F-4 may participate in maintaining epithelial cells in a proliferative, undifferentiated phenotype, whereas E2F-5 may be important to maintain the differentiated state. Thus, selective regulation of E2F forms occurs during murine epithelial development, irrespective of the ectodermal or endodermal origin of such epithelia.
M-PPM noncoherent receivers for UWB applications (2006)

The paper investigates ultra-wideband receivers for applications in sensor and control networks, M-ary pulse position modulation is considered and the detector operates with no knowledge of the channel response. It is shown that the optimum decision rule consists of comparing the signal energies received in the M possible pulse positions in a symbol interval and deciding for that position corresponding to the maximum energy. Simple synchronization algorithms are proposed and their performance is assessed by simulation over realistic multipath channels. The algorithms are non-data-aided (blind) and have a feedback structure in which the error signal is based on energy measurements from the received waveform. The receiver performance degradations due to timing errors are found to be marginal
Purification, crystallization and preliminary X-ray crystallographic analysis of the nucleocapsid protein of Bunyamwera virus (2006)

Bunyamwera virus (BUNV) is the prototypic member of the Bunyaviridae family of segmented negative-sense RNA viruses. The BUNV nucleocapsid protein has been cloned and expressed in Escherichia coli. The purified protein has been crystallized and a complete data set has been collected to 3.3 angstroms resolution at a synchrotron source. Crystals of the nucleocapsid protein belong to space group C2, with unit-cell parameters a = 384.7, b = 89.8, c = 89.2 angstroms, beta = 94.4 degrees . Self-rotation function analysis of the X-ray diffraction data has provided insight into the oligomeric state of the protein as well as the orientation of the oligomers in the asymmetric unit. The structure determination of the protein is ongoing.
Introspective semantic segmentation (2014)

Traditional approaches for semantic segmentation work in a supervised setting assuming a fixed number of semantic categories and require sufficiently large training sets. The performance of various approaches is often reported in terms of average per pixel class accuracy and global accuracy of the final labeling. When applying the learned models in the practical settings on large amounts of unlabeled data, possibly containing previously unseen categories, it is important to properly quantify their performance by measuring a classifier's introspective capability. We quantify the confidence of the region classifiers in the context of a non-parametric k-nearest neighbor (k-NN) framework for semantic segmentation by using the so called strangeness measure. The proposed measure is evaluated by introducing confidence based image ranking and showing its feasibility on a dataset containing a large number of previously unseen categories.
Electron-Beam Induced Growth of Bare Silver Nanowires from Zeolite Crystallites (2001)

Silver nanowires grow from highly Ag+-loaded zeolitesat the impact of the electron beam from a transmission electron microscope. Both bent, polycrystalline (see Figure), and straight single crystal wires (15 to 150 nm wide, and up to tens of μm long) can be obtained. Their formation can be rationalized as the reduction of Ag+ within the zeolite, accumulation of Ag metal in mesopores, and finally the breaching of the crystallite surface (see the collage of images on the inside front cover).
New Method for Synthesis of Methylenebis(diarylphosphine) Monoxides (1991)

Synthesis of methylenebis(diphenyl- and methylenebis(di-p-tolylphosphine) monoxides, via the reaction of diarylphosphines with formic acid in presence of concentrated hydrochloric acid is described. Methylenebis(diphenylphosphine) monoxide is oxidized with hydrogen peroxide and sulfur into the corresponding methylenebis(diphenylphosphine) dioxide and methylenebis(diphenylphosphine) monoxide monosulfide. Attempts to carry out this reaction with butylphenyl- and dibutylphosphines failed.
Double Michael Addition Reaction of Bischalcone under Ultrasound (2004)

The Michael addition of 1,5-diaryl-1,4-pentadien-3-ones with active methylene compounds has been the subjects of many investigations. Ultrasound has increasingly been used in organic synthesis in the last three decades. Compared with traditional methods, this method is more convenient and easily controlled. A large number of organic reactions can be carried out in higher yield, shorter reaction time or milder conditions under ultrasonic irradiation. KF/Al2O3 as a useful solid supported catalyst has received considerable attention because of their high level of chemoselectivity and environmental compatibility as well as simplicity of operation and their ready availability at low cost. Herein we report the double Michael addition of dibenzalacetone with active methlene compounds such as dimethyl malonate, diethyl malonate,methyl cyanoacetate and ethyl cyanoacetate catalyzed by KF/Al2O3 under ultrasound irradiation.……
Flow Rate Measurement Inside Polymer Microfluidic Systems Using Carbon Nanotube Sensors (2006)

We have demonstrated a carbon nanotube (CNT) based thermal flow sensor array capable of detecting air flow inside a polymethylmethacrylate (PMMA) micro fluidic chamber. The micro sensors are fabricated on a PMMA substrate using an AC electrophoretic technique to form bundled multi-walled carbon nanotube (MWNT) sensing elements between microelectrodes and then embedded inside the PMMA chamber which is fabricated using SU-8 molding/hot-embossing technique. We have tested the sensors using a hot-film anemometry constant current configuration for dynamic characterization. Preliminary results indicated that the MWNT sensors were capable of sensing input fluid flow variations inside the chamber. We have also measured the I-V characteristic of the resulting device and the results revealed that the sensor could be operated in /spl mu/W range, which is three orders of magnitude lower than conventional MEMS polysilicon based shear stress sensors. Based on these experimental evidences, we propose that carbon nanotubes is a novel material for fabricating micro flow sensors on polymer substrates - polymer-based devices which may serve as alternative sensors for silicon based flow sensors when bio-compatibility and low-cost applications are required.
<i>Cis</i>- and<i>trans</i>-acting factors regulating transcription of the BGT1 gene in response to hypertonicity (1998)

We have previously identified a tonicity-responsive enhancer (TonE) in the promoter region of the canine BGT1 gene. TonE mediates hypertonicity-induced stimulation of transcription. Here, we characterize TonE and TonE binding proteins (TonEBPs) to provide a biochemical basis for cloning of the TonEBPs. Mutational analysis applied to both hypertonicity-induced stimulation of transcription and TonEBP binding reveals that TonE is 11 base pairs in length, with the consensus sequence of (C/T)GGAAnnn(C/T)n(C/T). Activity of the TonEBPs increases in response to hypertonicity with a time course similar to that of transcription of the BGT1 gene. Studies with inhibitors indicate that translation, but not transcription, is required for activation of the TonEBPs. Phosphorylation is required for the stimulation of transcription but not for activation of DNA binding by the TonEBPs. In vivo methylation by dimethyl sulfate reveals that the TonE site of the BGT1 gene is protected with a time course like that of activity of the TonEBPs and activation of transcription. Ultraviolet cross-linking indicates that the TonEBPs share a DNA binding subunit of 200 kDa.
Orbital Fibroblasts From Thyroid Eye Disease Patients Differ in Proliferative and Adipogenic Responses Depending on Disease Subtype (2013)

We have demonstrated that OFs from TED patients have heterogeneous responses to proproliferative and proadipogenic stimulators in vitro in a manner that corresponds to their different clinical manifestations. Furthermore, we demonstrated a differential effect of COX inhibitors on type I and type II OF proliferation and adipogenesis.
Cyclosporine inhibition of calcineurin activity in human leukocytes in vivo is rapidly reversible. (1995)

Despite increasing information about the mechanism of action of cyclosporine A (CsA), little is known about the way lymphocytes recover from CsA. Recovery is central to understanding the pharmacodynamics of CsA in vivo. We studied the recovery of calcineurin phosphatase (CN) activity in CsA-treated cells. Single dose kinetics in renal transplant patients showed that inhibition of CN activity in PBL increased and fell concomitant with CsA blood vessels. In vitro, control PBL treated with CsA 100 micrograms/l, washed, and resuspended in CsA-free medium showed little recovery (0-20%) after 24 h. Erythrocytes or anti-CsA Ab added to the recovery medium increased recovery to 50% within 4 h. Similar recovery was seen in the ability of cells to produce IFN-gamma after OKT3 stimulation. Recovery of CN activity was associated with the efflux of [3H]CsA, was not blocked by cycloheximide and was temperature sensitive. A cell line with high expression of surface P glycoprotein (PGP), showed rapid recovery. However, PGP blockade did not prevent recovery in PBL, indicating a different PGP-independent mechanism. In PBL, recovery from CsA is slow and limited in vitro, but rapid in vivo, where CsA equilibrates among a complex set of extralymphocytic binding sites.
Nonthoracotomy Implantation of Cardioverter Defibrillators: Preliminary Experience with a Defibrillation Lead Placed at the Right Ventricular Outflow Tract (1996)

This article reports the preliminary observation that placement of defibrillation leads to the RV outflow tract in humans was possible and without dislodgment. RV outflow tract offers an alternative for placement of defibrillation leads, which may improve on the success of nonthoracotomy defibrillator implantation.
Covert channels in multiplayer first person shooter online games (2008)

Covert channels aim to hide the existence of communication between two or more parties. Such channels typically utilise pre-existing (overt) data transmissions to carry hidden messages. Internet-based covert channels often encode new information into unused (or loosely specified) IP packet header fields, or the time intervals between IP packet arrivals. We propose a novel covert channel embedded within the traffic of multiplayer, first person shooter online games. We encode covert bits as slight, yet continuous, variations of a playerpsilas characterpsilas movements. Movement information is propagated to all clients attached to a given game server, yet the channel remains covert so long as the variations are visually imperceptible to the human players. A modified version of Quake III Arena is used to demonstrate our concept. We empirically analyse the covert channelpsilas bit rate, and compare the statistical characteristics of unmodified game traffic with those of game traffic carrying covert information.