gebhart/patrepeval huggingface dataset:
Specific postsynaptic density proteins bind tubulin and calmodulin-dependent protein kinase type II. (1986)

Cytoskeletal interactions which contribute to the assembly of the postsynaptic density (PSD) were investigated. PSDs bound 125I-tubulin specifically with an apparent Km of 2 X 10(-7) M and a Bmax of about 1 nmol/mg of protein. 125I-Tubulin blots revealed that a group of polypeptides between Mr 135,000 and 147,000 (P-140) was a major tubulin-binding PSD component. The P-140 polypeptides were highly enriched in the PSD fraction of purified synaptosomes and could not be detected in crude brain cytoplasm preparations. These polypeptides were subject to phosphorylation by endogenous calmodulin-dependent protein kinase type II, with a concomitant reduction in 125I-tubulin binding. The tubulin-binding polypeptides could also associate with the radiolabeled alpha- and beta-subunits of the calmodulin-dependent protein kinase. These observations are consistent with a role for the P-140 polypeptides in organizing the molecular structure of the PSD. The data also suggest that this structure may be modified by Ca2+-sensitive phosphorylation, thus permitting neuronal activity to modulate the cytoskeletal interactions of the PSD.
Aromatic Substitution of Olefins by Palladium Salts (1973)

This review deals with the aromatic substitution of olefins by palladium salts. The scope and usefulness of the reaction, beginning with its discovery and including its application to the synthesis of aromatic substituted olefins are discussed under the following topics. 1. Reactions of the Styrene-Palladium(II) Chloride Complex 2. Reactions of Olefins with Palladium(II) Acetate 3. Catalytic Aspects of the Reaction 4. Reactions of Olefins with Organomercury Compounds
Changes in the agglutinating antibody titer and serum protein composition of colored carp after immunization with Aeromonas hydrophila. (1987)

Aeromonas hydrophila のホルマリン死菌を抗原として免疫したニシキゴイの血清中における凝集抗体価とタンパクの変化を,ゲルろ過と電気泳動によって分析し,次の結果を得た。1.免疫したニシキゴイの血清中の凝集抗体価は,1週間後から急速に上昇し,4週間後には1:2,048～8,192となり,ピークに達した。2.セルロースアセテート膜電気泳動では,免疫魚と非免疫魚の間に,とくに差異が認められなかった。3.寒天ゲル免疫電気泳動では,免疫魚の血清のアルブミンからα-グロブリン領域の沈降線が陽極側に長く延びる変化を示した。4.ポリアクリルアミドゲルディスク電気泳動ではRm値0.10～0.15付近のバンドが,免疫に伴って濃度が増すことが認められた。5.免疫魚と非免疫魚の血清をSephadex G-200を用いてゲルろ過したところ,4画分に分けられた。凝集抗体活性はこれらのうち最も分子量の大きな画分にのみ認められ,2-ME処理により消失した。
Ultrasonic Measurement of Respiratory Flow (1980)

We review ultrasonic measurement of fluid flow with emphasis on ultrasonic pneumotachometers (UPTM's). For PTM's we discuss specifications such as dynamic range, resistance, and frequency response. We review fluid flow principles and point out the problems of nonultrasonic PTM's For UPTM's we describe transducer construction, attenuation versus frequency, reflection at interfaces, and acoustic field patterns. We present four principle types: 1) time of flight, 2) sing around, 3) phase shift, and 4) phase-locked frequency shift. For each, we detail principles, advantages, disadvantages, and potential for future development.
One-Pot Syntheses of Dissymmetric Diamides Based on the Chemistry of Cyclic Monothioanhydrides. Scope and Limitations and Application to the Synthesis of Glycodipeptides (2009)

Opening cyclic monothioanhydrides by amines provides a convenient entry into amido thioacids that can be trapped in situ by 2,4-dinitrobenzenesulfonamides, by electron-deficient azides, or by amines in the presence of Sanger's reagent leading, in each case, to dissymmetric diamides in what can be considered a one-pot, three-component coupling sequence. The use of monothiomaleic anhydride and bifunctional nucleophiles such as amino thiols provides access to heterocyclic amides. The low reactivity of cyclic monothioanhydrides toward alcohols enables the use of methanol as solvent and obviates the need for the protection of alcohols in the various reaction components. Reaction of N-benzyloxycarbonyl-l-aspartic monothioanhydride with unprotected glycosyl amines, followed by capture of the thioacid intermediate with N-sulfonyl amino acid derivatives results in a three-component convergent synthesis of glycosylated peptides.
Seeing through the appearance: Body shape estimation using multi-view clothing images (2015)

We propose a learning-based algorithm for body shape estimation, which only requires 2D clothing images taken in multiple views as the input data. Compared with the use of 3D scanners or depth cameras, although our setting is more user friendly, it also makes the learning and estimation problems more challenging. In addition to utilizing ground truth body images for constructing human body models at each view of interest, our work uniquely associates the anthropometric measurements (e.g., body height or leg length) across different views. For performing body shape estimation using multi-view clothing images, the proposed algorithm solves an optimization task which recovers the body shape with image and measurement reconstruction guarantees. In the experiments, we will show that the use of our proposed method would achieve satisfactory estimation results, and performs favorably against single-view or other baseline approaches for both body shape and measurement estimation.
Formation of black tea aroma (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of black tea aromaGary W. Sanderson and Harold N. GrahammCite this: J. Agric. Food Chem. 1973, 21, 4, 576–585Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://doi.org/10.1021/jf60188a007Request reuse permissionsArticle Views1283Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Synthesis, Biological Testing, and Binding Mode Prediction of 6,9-Diarylpurin-8-ones as p38 MAP Kinase Inhibitors (2007)

Based on the purine scaffold of ATP, derivatives of 6,9-diarylpurine-8-one were prepared and tested for their ability to inhibit p38 MAP kinase, a key enzyme in the cellular regulation of proinflammatory cytokines. The inhibitor design combines the purine system of the authentic cosubstrate ATP with various phenyl moieties to explore the selectivity for the two hydrophobic regions of the kinase's ATP-binding cleft. The present study indicates a new binding mode of our scaffold to p38 MAP kinase, which comprises the desired structural features of ATP and the N-phenyl-N-purin-6-yl ureas previously published by Wan et al. Combinations of Autodock and FlexX docking with different scoring functions were used to assess the postulated binding mode. The predictive power of different docking-scoring combinations was determined. The presented results may form a solid basis for further optimization cycles since our theoretical findings are consistent with our experimental binding data and supported by the literature.
Site Specificity of Atherosclerosis (2003)

Atherosclerosis is a complex disease process that affects very specific sites of the vasculature. It is recognized that hemodynamic forces are largely responsible for dictating which vascular sites are either susceptible or resistant to developing atherosclerosis. In addition, a number of systemic and local factors also modulate the pathogenesis of the disease. By studying the development of atherosclerosis in mice, investigators have gained insights into the molecular mechanisms of this disease, although studies have largely focused on a single vascular site. Here, we review those recent studies in which vascular site-specific effects on atherosclerosis were reported when more than 1 site was examined. We assess the hypothesis that regional differences in the hemodynamic profile prime the endothelial phenotype to respond distinctly to such systemic risk factors as hypercholesterolemia, genetics, immune status, gender, and oxidative stress. Because a given treatment may differentially affect the development of atherosclerotic lesions throughout the vasculature, the sites chosen for study are critically important. By accounting for the complex interplay of factors that may operate at these different sites, a more complete understanding of the overriding mechanisms that control the initiation and progression of the atherosclerotic lesion may be realized.
Linezolid safety, tolerability and efficacy to treat multidrug- and extensively drug-resistant tuberculosis (2011)

diminished central motor output required to drive the respiratory muscles. Thus, the associated perceived effort required to generate a given ventilation during exercise is similarly reduced. The deeper, slower breathing pattern after radiation therapy and delay in the onset of tachypnoea reflect the recruitment of IC both at rest and during exercise as a result of lung volume deflation. Thus, the patient could increase tidal volume and ventilation during exercise to a greater extent than previously, before reaching critical mechanical constraints. For this reason, the onset of intolerable dyspnoea was delayed and the limits of tolerance extended.
A Chemotype That Inhibits Three Unrelated Pathogenic Targets: The Botulinum Neurotoxin Serotype A Light Chain, <i>P. falciparum</i> Malaria, and the Ebola Filovirus (2011)

A 1,7-bis(alkylamino)diazachrysene-based small molecule was previously identified as an inhibitor of the botulinum neurotoxin serotype A light chain metalloprotease. Subsequently, a variety of derivatives of this chemotype were synthesized to develop structure-activity relationships, and all are inhibitors of the BoNT/A LC. Three-dimensional analyses indicated that half of the originally discovered 1,7-DAAC structure superimposed well with 4-amino-7-chloroquinoline-based antimalarial agents. This observation led to the discovery that several of the 1,7-DAAC derivatives are potent in vitro inhibitors of Plasmodium falciparum and, in general, are more efficacious against CQ-resistant strains than against CQ-susceptible strains. In addition, by inhibiting β-hematin formation, the most efficacious 1,7-DAAC-based antimalarials employ a mechanism of action analogous to that of 4,7-ACQ-based antimalarials and are well tolerated by normal cells. One candidate was also effective when administered orally in a rodent-based malaria model. Finally, the 1,7-DAAC-based derivatives were examined for Ebola filovirus inhibition in an assay employing Vero76 cells, and three provided promising antiviral activities and acceptably low toxicities.
Cyclin E and Prognosis in Patients with Breast Cancer (2002)

An early and essential event in the evolution of cancer is loss of the normal control mechanisms responsible for the orderly progression of cells through the cell cycle, with consequent reduced fidelity of DNA replication and inappropriate cell division. Cyclins are the regulatory partners of the cyclin-dependent kinases (CDKs), which form the molecular control mechanisms responsible for cell-cycle progression.An advanced understanding of cell-cycle control has evolved over the past decade, since it became apparent that the underlying machinery of this fundamental biologic process was conserved during evolution. Indeed, the importance of these control mechanisms and their relevance to human . . .
Liquid-crystal waveguides for integrated optics (1977)

Liquid-crystal optical waveguides may be modulated or switched with high sensitivity by electrooptic, magnetooptic or acoustooptic effects. Such guides, however, have relatively slow response times and relatively high scattering losses so that they currently appear limited to special-purpose applications. A review is given on a variety of liquid-crystal optical switches or modulators. Specific work is then described on the analysis and experiment on thin-film nematic liquid-crystal guides with propagation constant controlled by means of an applied voltage across the films. A dynamic scattering switch is also demonstrated. Recent results show switchable grating directions in films having mixtures of nematic and cholesteric liquid crystals. The controlling variable is the frequency of the applied electric field.
Thallium 201 myocardial imaging in patients with pulmonary hypertension. (1976)

The appearance of the right ventricular myocardium on thallium 201 myocardial perfusion images was evaluated in patients with chronic pulmonary hypertension and compared to patients without pulmonary hypertension. Four groups of patients were studied: 1) eight normals, 2) five patients with angiographically documented coronary artery disease and normal pulmonary artery pressures, 3) ten patients with moderate to severe pulmonary parenchymal or vascular disease and documented pulmonary hypertension and 4) eight patients with chronic left ventricular dysfunction and pulmonary hypertension discovered during cardiac catheterization. The right ventricular free wall was visualized on the thallium 201 myocardial perfusion image in only one of eight normals (group 1) and in only one of the five patients with coronary artery disease (group 2) and measured 0.5 cm and 0.9 cm in thickness, respectively. In patients with documented pulmonary hypertension the right ventricle was visualized on low contrast thallium 201 myocardial perfusion image in all patients. The apparent right ventricular free wall thickness measured from the ungated thallium 201 myocardial perfusion images was 1.7 +/- 0.3 cm in group 3 and 1.5 +/- 0.2 cm in group 4. Right ventricular hypertrophy was detected by electrocardiography in only five of ten patients in group 3 and only one of eight patients in group 4. Thallium 201 myocardial perfusion imaging appears to be a useful technique for assessing the effects of chronic pulmonary hypertension on the right ventricular myocardium.
Tolerance-Based Wafer Verification Methodologies with a Die-to-Database Inspection System (2009)

With a die-to-database inspection system using electron beam, we have constructed state-of-the-art verification methodologies for the design for manufacturability (DfM), process proximity correction (PPC), minimization of process errors and process fluctuations, and so on. The experimental methodologies make it possible to extract exact hotspots and result in short development turnaround time (TAT) in low k1 lithography. In the methodologies, the die-to-database inspection system, NGR-2100, has remarkable features for the full-chip inspection within reasonable operating time. This system is equipped with tolerance-based "verifiers" and provides higher hotspot extraction accuracy than the conventional optical inspection tool. As a result, hotspots extracted using the system included all killer hotspots extracted by electrical and physical analyses. In addition, the new methodologies are highly advantageous in that they shorten the development TAT by two to four months. In the application to 65-nm-node complimentary metal oxide semiconductor (CMOS) devices, we verified yield improvement using the proposed methodologies.
Effect of Preheating and Post-Curing Time on the Mechanical Properties of Epoxy Resin (2013)

The purpose of this study is to compare the mechanical properties in the form of ultimate tensile strength, ultimate tensile strain and Young's modulus of an epoxy resin at different curing cycles. The work carried out consisted of investigating the effect of preheating time and then the effect of post-curing time at the same temperature. Five repeats of static tensile tests were then carried out using universal test machine. Results indicated that compared to a shorter epoxy resin preheat duration of 15 min at 80°C, a longer duration of 30 min at 80°C of preheating degrades the material ultimate tensile strength and ultimate tensile strain leading to a suffer material. However, compared to no further post-curing of the epoxy resin, a two-hour post-cure duration at 80°C slightly increased the ultimate tensile strength and significantly decreased the ultimate tensile strain making the material even suffer than in the case of preheating. The implication is that in-house cure cycle tests should be carried out to characterize the resin instead of exclusively relying on resin manufacturer proposed cure cycles.
Comparative Immunogenicity of Heat-Killed and Living Oral <i>Salmonella</i> Vaccines (1972)

CD-1 mice were vaccinated intragastrically or intramuscularly with one or two doses of 200 mug of heat-killed Salmonella enteritidis 5694. Control mice were vaccinated with sublethal doses of living S. enteritidis Se795. The mice were challenged intragastrically with approximately 10(6)S. enteritidis 5694 SM(R) 7 to 14 days later, and the growth of the challenge population in the liver, spleen, mesenteric lymph nodes, lungs, and intestine was measured quantitatively. Mice receiving two doses of heat-killed vaccine by mouth were able to delay the systemic emergence of a gastrically introduced salmonella infection by 1 to 2 days. The corresponding liver and spleen populations were slightly lower than those seen in the normal controls. On the other hand, mice receiving the living, attenuated vaccine (either intravenously or intragastrically) developed an effective anti-salmonella immunity against subsequent reinfection.
<title>Noise reduction in ultrasound images using multiple linear regression in a temporal context</title> (1991)

An algorithm is presented for speckle reduction in time varying images. The algorithm operates in the time domain and is based on a subdivision of the time evolution of each pixel in the image into homogenous zones. The algorithm operates on a finite time window. The intensity evolution in this window is processed individually for each pixel in the image. The restored time evolution is defined as a piecewise linear function with a predefined maximal number of linear segments. The maximal number of segments is a parameter of the algorithm. Dynamic programming has been applied to obtain the piecewise linear function that minimizes the mean square error. For more than one segment the algorithm finds the optimal way to subdivide the time evolution into homogenous zones. Ordinary linear curve regression is used within each homogenous time segment. Several alternatives for temporal filtering based on discontinuity detection are discussed. The proposed algorithm reduces nonstationary speckle and increases the image contrast.
Histone deacetylase (2003)

分子標的としてのヒストンデアセチラーゼ(HDAC)がいま大変注目されている. ヒストンアセチル化は転写など, DNAの機能制御に関わるクロマチンの構造機能の調節システムとして重要である. HDACは発癌や腫癌血管新生に関与し, その阻害剤の臨床試験がはじまっている. 本稿ではHDACの多様な生理機能とその阻害剤の分子作用機構を解説し, さらに次世代のHDAC阻害剤への展望について述べたい.
Coupling a Single Trapped Atom to a Nanoscale Optical Cavity (2013)

Hybrid quantum devices, in which dissimilar quantum systems are combined in order to attain qualities not available with either system alone, may enable far-reaching control in quantum measurement, sensing, and information processing. A paradigmatic example is trapped ultracold atoms, which offer excellent quantum coherent properties, coupled to nanoscale solid-state systems, which allow for strong interactions. We demonstrate a deterministic interface between a single trapped rubidium atom and a nanoscale photonic crystal cavity. Precise control over the atom's position allows us to probe the cavity near-field with a resolution below the diffraction limit and to observe large atom-photon coupling. This approach may enable the realization of integrated, strongly coupled quantum nano-optical circuits.
Prevention and Treatment of Skin Aging (2006)

Skin aging is a complex biological process that is a consequence of both intrinsic or genetically programmed aging that occurs with time, and extrinsic aging caused by environmental factors. The dramatic increase in the aging population and the psychosocial impact of skin aging has created a demand for effective interventions. The advances that have been made in the past 25 years in our understanding of the clinical, biochemical, and molecular changes associated with aging have led to the development of many different approaches to reduce, postpone, and in some cases, repair the untoward effects of intrinsic programmed aging and extrinsic environmental injury.
Gene Expression Profiling and Genetic Markers in Glioblastoma Survival (2005)

Despite the strikingly grave prognosis for older patients with glioblastomas, significant variability in patient outcome is experienced. To explore the potential for developing improved prognostic capabilities based on the elucidation of potential biological relationships, we did analyses of genes commonly mutated, amplified, or deleted in glioblastomas and DNA microarray gene expression data from tumors of glioblastoma patients of age >50 for whom survival is known. No prognostic significance was associated with genetic changes in epidermal growth factor receptor (amplified in 17 of 41 patients), TP53 (mutated in 11 of 41 patients), p16INK4A (deleted in 15 of 33 patients), or phosphatase and tensin homologue (mutated in 15 of 41 patients). Statistical analysis of the gene expression data in connection with survival involved exploration of regression models on small subsets of genes, based on computational search over multiple regression models with cross-validation to assess predictive validity. The analysis generated a set of regression models that, when weighted and combined according to posterior probabilities implied by the statistical analysis, identify patterns in expression of a small subset of genes that are associated with survival and have value in assessing survival risks. The dominant genes across such multiple regression models involve three key genes-SPARC (Osteonectin), Doublecortex, and Semaphorin3B-which play key roles in cellular migration processes. Additional analysis, based on statistical graphical association models constructed using similar computational analysis methods, reveals other genes which support the view that multiple mediators of tumor invasion may be important prognostic factor in glioblastomas in older patients.
TheaterLoc: a case study in building an information integration application (1999)

While there has been much written about various information integration technologies, there has been little said regarding how to combine these technologies together to build an entire application. In this paper, we describe the design and implementation of TheaterLoc, an information integration application that allows users to retrieve information about theaters and restaurants for cities in the Los Angeles area, including an interactive map depicting their relative locations and video trailers of the movies playing at the various area theaters. The data retrieved by TheaterLoc comes from five distinct heterogeneous and distributed sources. The enabling technology used to achieve the integration includes: the Ariadne information mediator, wrappers for each of the web-based data sources, and a video server to stream the movie trailers. We focus in detail on the mediator technologies, such as data modeling, source axiom compilation, and query planning. We also describe how the wrappers present an interface for querying data on web sites, aiding in information retrieval used during data integration. Finally, we discuss some of the major integration problems we encountered, as well as our plans to deal with them.