gebhart/patrepeval huggingface dataset:
120nm CMOS OPAMP with 690 MHz f/sub T/ and 128 dB DC gain (2005)

In this paper, an advancement to compensate multistage operational amplifiers is presented. High-gain and highspeed operational amplifiers can be realized with this approach. One example of such a high-gain amplifier with a unity-gain frequency of 693 MHz and DC gain of 128.8dB is presented. The high-speed settling is mainly reached by dominant Miller compensation via 4 stages.
Operational Research in Industry (1999)

Modelling Tools for Airline Crew Scheduling and Fleet Assignment Problems R.L.Ho, E.L.Johnson & T.L.Shaw Solving Fleet Scheduling Problems with Mixed-Integer Programming F.Uwe H.Suhl & L.M.Suhl Demand Adaptive Transit Systems F.Malucelli, M.Nonato & S.Pallottino Parallel Optimization with PC Networks R.Laundy Horizontal Marketing: Optimized One-To-One Marketing M.P.Haydock & E.Bibelnieks Data Mining Classification Problem: An LP Approach T.A.Ciriani, S.Gliozzi & M.Russo Mixed Integer Nonlinear Programming Applications J.Kallrath Lube Production Scheduling S.Barbariol, M.Lusetti, M.Mantilli & M. Scarioni Practical LP Model Behaviour L.Haverly A Continuous Time Representation for Multi-stage Factory Design and Scheduling T.Tahmassebi A Scheduling Prototype for the Factory Automation Matching OR Methodologies to the Actual Industrial Needs R.Tadei, F.Della Croce & S. Pucci Planning of Production in Semiconductor Manufacturing J.Ahmadi, R.Benson & D.Supernaw-Issen Cargo Analytical Integration in Space Engineering: A Three-Dimensional Packing Model G.Fasano Short Term Operation of an Electric Power System J.Gheury & T.Lekane The Unit Commitment Problem S.Takriti
Perfecting a text: authorial revisions in José Emilio Pacheco's "Morirás lejos" (1985)

Jos? Emilio Pacheco's first novel, Morir?s lejos, has enjoyed considerable critical acclaim and has been the subject of recent articles, dissertations, and books.1 Curiously, however, the bulk of this attention has centered almost exclusively on the second edition, described by the author as the segunda edici?n revisada, which appeared in November of 1977 and became an instant best-seller. The first edition had been published ten years earlier (November 1967), but it was largely ignored, and the 4200 copies remained in relative obscurity. This contrasting fortune of the two works calls for research which would attempt to postulate why the fate of each edition was so disparate.
Time series classification using Gaussian mixture models of reconstructed phase spaces (2004)

A new signal classification approach is presented that is based upon modeling the dynamics of a system as they are captured in a reconstructed phase space. The modeling is done using full covariance Gaussian mixture models of time domain signatures, in contrast with current and previous work in signal classification that is typically focused on either linear systems analysis using frequency content or simple nonlinear machine learning models such as artificial neural networks. The proposed approach has strong theoretical foundations based on dynamical systems and topological theorems, resulting in a signal reconstruction, which is asymptotically guaranteed to be a complete representation of the underlying system, given properly chosen parameters. The algorithm automatically calculates these parameters to form appropriate reconstructed phase spaces, requiring only the number of mixtures, the signals, and their class labels as input. Three separate data sets are used for validation, including motor current simulations, electrocardiogram recordings, and speech waveforms. The results show that the proposed method is robust across these diverse domains, significantly outperforming the time delay neural network used as a baseline.
Fast and efficient WDM network protection using p-cycles (2003)

p-Cycles are preconfigured protection cycles for meshed networks. A p-cycle protects on-cycle links, and off-cycle links having p-cycle nodes as endpoints. For WDM-networks, p-cycles can provide fast protection switching times and achieve high resource efficiency.
Urban target classifications using time-frequency micro-Doppler signatures (2007)

Moving target indicators (MTI) find important applications in urban sensing. While motion detection can be achieved using simple CW radars, characterization of moving targets can be provided by estimating the key parameters of the target micro-Doppler signature. For indoor sensing, this signature has underlying instantaneous frequency features, which may depend on the radar viewing angle. This paper considers typical animate and inanimate moving objects and presents time-frequency motion classifiers using quadratic time-frequency distributions. The distinctions between the different target micro-Doppler parameter values and bounds are delineated.
Development of Ultraviolet Taylor-Couette Reactor To Apply Non-Thermal Pasteurization On Milk (2012)

The research developed a UV Taylor Couette reactor for disinfecting milk as a model opaque fluid. The principal of the reactor was to generate laminar vortices to support efficient mixing and homogenous UV photon distribution. The UV reactor parameters were optimized to generate laminar vortices that were stabilized by modification of the unit with baffles. A model was developed to predict the UV dose required to inactivate model microbes in milk. Through verification trials it was noted the predicted UV dose underestimated that required to support a 5 log cfu reduction of microbes. It was subsequently identified that the deviation from predicted values could be attributed to fat content that enhances the UV inactivation of microbes in milk with proteins providing protection to microbes. In conclusion, the UV Taylor Couette reactor has strong potential for disinfecting opaque fluids although matrix effects need to be considered when undertaking validation trials.
Effects of 2-G exposure on temperature regulation, circadian rhythms, and adiposity in UCP2/3 transgenic mice (2000)

Altered ambient force environments affect energy expenditure via changes in thermoregulation, metabolism, and body composition. Uncoupling proteins (UCPs) have been implicated as potential enhancers of energy expenditure and may participate in some of the adaptations to a hyperdynamic environment. To test this hypothesis, this study examined the homeostatic and circadian profiles of body temperature (T(b)) and activity and adiposity in wild-type and UCP2/3 transgenic mice exposed to 1 and 2 G. There were no significant differences between the groups in the means, amplitudes, or phases of T(b) and activity rhythms at either the 1- or 2-G level. Percent body fat was significantly lower in transgenic (5.2 +/- 0. 2%) relative to the wild-type mice (6.2 +/- 0.1%) after 2-G exposure; mass-adjusted mesenteric and epididymal fat pads in transgenic mice were also significantly lower (P < 0.05). The data suggest that 1) the actions of two UCPs (UCP2 and UCP3) do not contribute to an altered energy balance at 2 G, although 2) UCP2 and UCP3 do contribute to the utilization of lipids as a fuel substrate at 2 G.
A variable-rate natural-quality parametric speech coder (2002)

A variable bit rate speech coder operating below 2 kb/s is presented which combines phonetic classification and frequency domain modeling. Each input frame is identified as one of the following classes: mixed voiced, fully voiced, unvoiced, noise, and silence. Based on the class parameter, a suitable parametric coding scheme (spectral analysis, modeling, quantization, and synthesis) is selected. The coder thereby adaptively matches a suitable coding scheme to the character of the input speech leading to variable rates ranging from 0.15 kb/s (for silence) to 2.6 kb/s (for mixed voiced). For typical conversational speech, the coder operates at an average rate of 1.4 kb/s while delivering speech quality that is subjectively preferred over Federal Standard 1016 CELP at 4.8 kb/s by a majority of listeners.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effects of Multiple-Enzyme Mixtures on Growth Performance of Broilers Fed Corn-Soybean Meal Diets (2004)

Two experiments were conducted under hot and cool seasons to investigate the effects of multiple-enzyme mixtures on the growth performance of broilers fed reduced energy corn-soybean meal diets. Broilers responded to enzyme supplementation with greater magnitude in the hot season (experiment 1) than in the cool season (experiment 2). Adding adequate activity levels of α-amylase, β-glucanase, and xylanase to broiler starter and grower corn-soybean diets with a 3% reduction in dietary ME allowed full restoration of growth performance of broilers comparable to those fed the adequate energy positive control diet regardless of season.
Secure personal data servers (2010)

An increasing amount of personal data is automatically gathered and stored on servers by administrations, hospitals, insurance companies, etc. Citizen themselves often count on internet companies to store their data and make them reliable and highly available through the internet. However, these benefits must be weighed against privacy risks incurred by centralization. This paper suggests a radically different way of considering the management of personal data. It builds upon the emergence of new portable and secure devices combining the security of smart cards and the storage capacity of NAND Flash chips. By embedding a full-fledged Personal Data Server in such devices, user control of how her sensitive data is shared by others (by whom, for how long, according to which rule, for which purpose) can be fully reestablished and convincingly enforced. To give sense to this vision, Personal Data Servers must be able to interoperate with external servers and must provide traditional database services like durability, availability, query facilities, transactions. This paper proposes an initial design for the Personal Data Server approach, identifies the main technical challenges associated with it and sketches preliminary solutions. We expect that this paper will open exciting perspectives for future database research.
<i>miR-17∼92</i> cooperates with <i>RB</i> pathway mutations to promote retinoblastoma (2011)

The miR-17~92 cluster is a potent microRNA-encoding oncogene. Here, we show that miR-17~92 synergizes with loss of Rb family members to promote retinoblastoma. We observed miR-17~92 genomic amplifications in murine retinoblastoma and high expression of miR-17~92 in human retinoblastoma. While miR-17~92 was dispensable for mouse retinal development, miR-17~92 overexpression, together with deletion of Rb and p107, led to rapid emergence of retinoblastoma with frequent metastasis to the brain. miR-17~92 oncogenic function in retinoblastoma was not mediated by a miR-19/PTEN axis toward apoptosis suppression, as found in lymphoma/leukemia models. Instead, miR-17~92 increased the proliferative capacity of Rb/p107-deficient retinal cells. We found that deletion of Rb family members led to compensatory up-regulation of the cyclin-dependent kinase inhibitor p21Cip1. miR-17~92 overexpression counteracted p21Cip1 up-regulation, promoted proliferation, and drove retinoblastoma formation. These results demonstrate that the oncogenic determinants of miR-17~92 are context-specific and provide new insights into miR-17~92 function as an RB-collaborating gene in cancer.
Novel endoscopic observation in Barrett’s oesophagus using high resolution magnification endoscopy and narrow band imaging (2007)

High resolution magnification endoscopy with NBI allows clear visualisation of microstructural and microvascular patterns within Barrett's oesophagus, and allows targeted biopsy with a high yield of SIM and high grade dysplasia.
Elimination stabilized alkyls. Part II. Neopentyl and related alkyls of chromium(IV) (1973)

Binary chromium(IV) alkyls, CrR4, R = CH2CMe3, CH2CMe2Ph, CH2CPh3, and CH3, have been prepared and characterised by electronic, i.r. and e.s.r. spectroscopy. The electronic and magnetic properties of tetrahedral chromium(IV) compounds are discussed.
Efficient aggregation for graph summarization (2008)

Graphs are widely used to model real world objects and their relationships, and large graph datasets are common in many application domains. To understand the underlying characteristics of large graphs, graph summarization techniques are critical. However, existing graph summarization methods are mostly statistical (studying statistics such as degree distributions, hop-plots and clustering coefficients). These statistical methods are very useful, but the resolutions of the summaries are hard to control.
High-resolution MR imaging of the vagina. (1997)

High-resolution magnetic resonance (MR) imaging with pelvic phased-array and endoluminal coils provides information on vaginal abnormalities heretofore not available with other imaging modalities. Congenital anomalies of the vagina can result from disorders of lateral fusion of the descending müllerian ducts and ascending urogenital sinus, developmental absence of the müllerian ducts, or disorders of vertical fusion. In these conditions, MR imaging can depict the presence or absence of the vagina, cervix, and uterus and help determine whether these structures contain a septum or are duplicated or distended with blood. Gartner duct cysts and Bartholin gland cysts have the same signal intensity characteristics, but the former are located in the anterolateral aspect of the proximal third of the vagina and the latter are in the posterolateral portion of the lower vagina. Entero-, vesico-, and ureterovaginal fistulas result from obstetric and surgical trauma, radiation therapy, or inflammatory bowel disease. MR imaging has great potential for detection and characterization of these fistulas. MR imaging can be used to detect and stage primary and secondary vaginal tumors. However, neither signal intensity nor patterns of enhancement enable confident prediction of the histologic subtype of vaginal malignancy.
Health risk of dental unit waterline system to dental patients – an issue of concern (2013)

Water delivered through dental unit waterline system (DUWS) is often reported contaminated with microbes dislodged from biofilm that forms within the tubing of a dental chair unit (DCU). ADM: The study aimed at evaluating the sanitary level of DCU water from a teaching dental clinic. Materials: The presence of pathogenic bacteria which include total coliforms, faecal coliforms, E. coli, faecal streptococci and P. aeruginosa were determined using conventional microbiological methods while PCR technique was used to identify other microbial contaminants. Result: pH of DCU water was found slightly acidic at pH 5.4-5.5 and the temperature was 23?C. Pathogenic contaminants were absent but the DCU water was highly loaded with Sphingomonas rhizogenes (17.9%), Sphingomonas dokdonesis (79.5%), Sphingomonas mucosissima (1.1%) and Methylobacterium radiotolerans (1.5%). The high load of microbes that exceeded 200 cfu/ml was of great concern as it failed to meet recommendation set by the American Dental Association.
Decoupling of a Disk Resonator From Linear Acceleration Via Mass Matrix Perturbation (2011)

Axisymmetric microelectromechanical (MEM) vibratory rate gyroscopes are designed so the central post which attaches the resonator to the sensor case is a nodal point of the two Coriolis-coupled modes that are exploited for angular rate sensing. This configuration eliminates any coupling of linear acceleration to these modes. When the gyro resonators are fabricated, however, small mass and stiffness asymmetries cause coupling of these modes to linear acceleration of the sensor case. In a resonator postfabrication step, this coupling can be reduced by altering the mass distribution on the resonator so that its center of mass is stationary while the operational modes vibrate. In this paper, a scale model of the disk resonator gyroscope (DRG) is used to develop and test methods that significantly reduce linear acceleration coupling.
Wireless Location in Non-Line-of-Sight Environments (2004)

As the wireless personal communications industry grows rapidly, there is an increasing demand for accurate position location of a mobile station (MS) to provide emergency and other value-added services.Several location techniques utilizing terrestrial wireless network elements and radio signals have been proposed over the years.However, accurate positioning in a terrestrial wireless system is impeded by non-line-of-sight (NLOS) propagation and hearability issues.Traditional location algorithms have made the assumption that a lineof-sight (LOS) path exists between the MS and each base station (BS).This assumption is seldom met in the real world.The problem with early algorithmic approaches developed to deal with NLOS errors has been the tendency to trade-off location accuracy with the number of participating BSs.These location schemes require that there exist a large number of network elements that can "hear", that is, receive signals from or transmit to, a MS with acceptable link quality.This is not feasible in practical wireless networks for a variety of reasons.The algorithms proposed in this dissertation use just the minimum number of BSs and adopt a constrained optimization approach for location estimation with NLOS error mitigation.Based on novel constraints derived from the geometry or bounds on the location errors based on measurement history, these algorithms attempt to estimate the true location parameters such as Times of Arrival (TOAs) and Angles of Arrival (AOAs).Also proposed is a novel hybrid geometrical method that utilizes the time difference of arrival (TDOA) and AOA approach for position location.Another aspect of this thesis deals with range-based statistical techniques to identify if the signal propagation is LOS or NLOS.We will present theoretical analysis and simulation results that substantiate our claims.
Local Accuracy and Global Consistency for Efficient SLAM (2012)

This thesis is concerned with the problem of Simultaneous Localisation and Mapping (SLAM) using visual data only. Given the video stream of a moving camera, we wish to estimate the structure of the environment and the motion of the device most accurately and in real-time. Two effective approaches were presented in the past. Filtering methods marginalise out past poses and summarise the information gained over time with a probability distribution. Keyframe methods rely on the optimisation approach of bundle adjustment, but computationally must select only a small number of past frames to process. We perform a rigorous comparison between the two approaches for visual SLAM. Especially, we show that accuracy comes from a large number of points, while the number of intermediate frames only has a minor impact. We conclude that keyframe bundle adjustment is superior to ltering due to a smaller computational cost. Based on these experimental results, we develop an efficient framework for large-scale visual SLAM using the keyframe strategy. We demonstrate that SLAM using a single camera does not only drift in rotation and translation, but also in scale. In particular, we perform large-scale loop closure correction using a novel variant of pose-graph optimisation which also takes scale drift into account. Starting from this two stage approach which tackles local motion estimation and loop closures separately, we develop a unified framework for real-time visual SLAM. By employing a novel double window scheme, we present a constant-time approach which enables the local accuracy of bundle adjustment while ensuring global consistency. Furthermore, we suggest a new scheme for local registration using metric loop closures and present several improvements for the visual front-end of SLAM. Our contributions are evaluated exhaustively on a number of synthetic experiments and real-image data-set from single cameras and range imaging devices.
Flexibility of dna binding domain of <i>trp</i> repressor required for recognition of different operator sequences (1996)

Trp repressor (25 kDa) is a regulatory protein that controls transcription initiation in the tryptophan biosynthetic operon and at least four other operons in Escherichia coli. An alanine to valine mutation (AV77) in the DNA binding domain is known to increase repressor activity at the trp operator in vivo, but not in vitro. We report here the amide proton exchange rates for the DNA-binding domains of both the wild-type and AV77 proteins. We find that the alanine to valine change stabilizes the flexible DNA-binding domain of the repressor. We present in vivo data showing that, although the AV77 repressor is more inhibitory at the trp operator than the wild-type repressor, it does not have increased activity at the aroH or trpR operator; repression at the aroH operator is, in fact, reduced. Our results suggest that the flexibility exhibited by the wild-type repressor allows a broader range of repressor/DNA interactions, whereas the increased rigidity resulting from the AV77 change limits the repressor's effectiveness at some operators.
Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin (2011)

A major challenge in the treatment of cancer is multidrug resistance (MDR) that develops during chemotherapy. Here we demonstrate that tiopronin (1), a thiol-substituted N-propanoylglycine derivative, was selectively toxic to a series of cell lines expressing the drug efflux pump P-glycoprotein (P-gp, ABCB1) and MRP1 (ABCC1). Treatment of MDR cells with 1 led to instability of the ABCB1 mRNA and consequently a reduction in P-gp protein, despite functional assays demonstrating that tiopronin does not interact with P-gp. Long-term exposure of P-gp-expressing cells to 1 sensitized them to doxorubicin and paclitaxel, both P-gp substrates. Treatment of MRP1-overexpressing cells with tiopronin led to a significant reduction in MRP1 protein. Synthesis and screening of analogues of tiopronin demonstrated that the thiol functional group was essential for collateral sensitivity while substitution of the amino acid backbone altered but did not destroy specificity, pointing to future development of targeted analogues.
Bar codes and their potential applications in hospital pharmacy (1985)

The technology and terminology of bar codes, the Health Industry Bar Code (HIBC) Standard, issues facing the pharmaceutical industry with respect to bar codes, and potential applications of bar codes in hospital pharmacy are reviewed. Bar codes consist of a series of parallel alternating dark lines and empty spaces. Commonly used bar codes include UPC (Universal Product Code), Interleaved 2 of 5, Codabar, Code 93, Code 128, and Code 39. There are several different types of scanners that may be used for scanning bar codes. Some of the variable features are portability, contact and noncontact, autodiscrimination, and the presence of numeric keypads. The HIBC Council (HIBCC) is a steering committee charged with developing bar-code standards for health care, assigning identification numbers to manufacturers, and providing information to interested individuals. The HIBCC Board includes representatives from health-care providers, equipment manufacturers, drug manufacturers, and wholesalers. Drug manufacturers are concerned about several issues with regard to bar codes; for example, who will pay for the cost of implementation, on what level of packaging will the bar codes be required, and are there legal implications if a poor scan results in patient harm? Bar codes have already been applied in some hospitals for coding blood containers, roentgenogram jackets, medical records, and capital equipment. The potential applications in hospital pharmacy include inventory control, verifying the accuracy of dispensing to both inpatients and outpatients, and record keeping for drug product expiration or disposal. Bar codes also offer pharmacists the ability to perform in-process dispensing controls that are not practical to perform manually. Bar-code technology offers health-care personnel the opportunity to improve work efficiency and increase the accuracy of data entry into automated systems.