gebhart/patrepeval huggingface dataset:
헤어 패션 감각(感覺)에 관(關)한 연구(硏究) -수도권(首都圈) 대학(大學) 여학생(女學生)을 대상(對象)으로- (2005)

This study aims to know the deferences of hair fashion feeling group in accordance with hair styling activities, general characteristics, life styles objecting to capital area university women students and aid to hair fashion design. So the results are as belows. 1. Frequency Analysis of Categories A. Hair fashion feeling - Natural, sexy, romantic pretty, sophisticate, ethnic are 90% in total hair fashion feeling variables in sequence of frequency, so it can be said these are in vogue. B. Hair styling activities - The objections visit the hair salon once 1-2months, spend about 42,000 won a month, perform cut & wave perm to sentimental reasens & hair style changes, determine the hair style well coordinated in her image and managed easily. In her home, they manage her hair style 12 minutes a day, spend 17,000 won to buy hair aids, do hair blow dry or pin or pony tail mainly in the morning, scarcely use the hair styling aids but if use, essence or wax mainly. And the degree of interest to hair style is high. C. General Characteristics - The objections`s average age is 21.1, residence is seoul kangnam 23.3%, seoul kangbook 18.4%, other capital areas 58.4%, the degree of education is university students 94.9%, graduated student 5.1%, marriage is married 96%, unmarried 2.8%, family who live with is married are mainly man & woman and living with father & mother in low in man`s, unmarried are mainly live alone & nuclear family, personal expenses a month is 300,000 won in average, income of home is 4,000,000 won a month. D. Life style - The objections are not in interest of physical exercises but if are, do yoga & health, like drama & comedies program, watch TV or meet friend in leisure time, like balad & dance music, fashion magazine, meet friend in cafe or college. 2. Relationship of hair fashion feeling & other variables Using the x2-test, level p<0.05, Hair styling activities(frequency of hair salon coming in and out, ordinary time representing hair style, preferred hair styling aids, the amount of hair style interest), General Characteristics(age), Life style(leisure time) variables are meaningful.
Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas. (1992)

The frequency of H-ras, K-ras, and N-ras mutations and the presence of high-risk human papillomavirus (HPV 16, 18, and 33) DNA were studied in 75 paraffin-embedded specimens obtained from 68 Japanese patients with a variety of prostate carcinomas by using polymerase chain reaction and DNA hybridization with sequence-specific oligonucleotides. Ten specimens each of normal and benign hyperplastic prostatic tissues from the same number of patients were also examined for this analysis. Of 68 carcinoma cases, ras gene mutations were present in 16 cases (24%) and HPV DNAs in 28 cases (41%). Eleven mutations were detected in codon 61 of H-ras, 4 in codon 12 of N-ras, and 2 in codon 61 of K-ras. HPV 16, 18, and 33 DNAs were found in 11, 17, and 5 cases, respectively. Eight of the 16 cases with ras mutation also harbored HPV DNAs. The frequency of ras mutations and the HPV infection increased in patients with advanced stages of the tumor and with the higher Gleason score. There was the predominant presence of H-ras codon 61.2 (CAG-->CTG) mutation and HPV 18 DNA in prostatic carcinomas metastasizing to the bone. None of the normal or benign hyperplastic prostatic specimens contained either ras mutation or HPV DNA. Our results suggest that ras gene mutations and HPV infections are relatively frequent, at least in prostate carcinoma of Japanese patients. These two factors appear to be related to the progression of the tumor. Moreover, H-ras codon 61.2 mutation and HPV 18 infection may have some predictive roles for bone metastasis in prostate carcinoma.
Detecting packed executables using steganalysis (2014)

This paper proposes a novel method of detecting packed executable files using steganalysis, primarily targeting the detection of obfuscated malware through packing. Considering that over 80% of malware in the wild is packed, detection accuracy and low false negative rates are important properties of malware detection methods. Experimental results outlined in this paper reveal that the proposed approach achieving an overall detection accuracy of greater than 99%, a false negative rate of 1% and a false positive rate of 0%.
Decreased Hepatic Uroporphyrinogen Decarboxylase Activity in Porphyria Cutanea Tarda (1982)

To test whether reduced hepatic uroporphyrinogen decarboxylase activity is a specific and intrinsic defect in porphyria cutanea tarda, we measured enzymatic activity in the livers of 17 patients with porphyria cutanea tarda, 12 "normal" control patients without liver disease, and 41 patients with other forms of porphyria, alcoholic liver disease, hemochromatosis, or chronic hepatitis. Enzyme activity in all the patients with porphyria cutanea tarda was lower than in the patients without this disease, except for one patient with alcohol-induced fatty liver. Reduction of hepatic iron stores by phlebotomy did not alter the enzymatic activity in porphyria cutanea tarda. We conclude that reduced hepatic uroporphyrinogen decarboxylase activity is a specific and intrinsic hepatic defect in porphyria cutanea tarda, but modulation of uroporphyrinogen synthesis by extrinsic factors is required for the full biochemical expression of the disease.
Lipid Peroxidation and Altered Anti-oxidant Status in Breast Adenocarcinoma Patients (2014)

Increased lipid peroxidation is more pronounced in breast cancer patients and as a adaptive mechanism antioxidants system was upregulated. Therefore, measurement of oxidative stress will be an affective prognosis factor and that may aid to design new therapeutic drugs for cancer treatment.
Towards a Ready-to-Use Drivers' Vigilance Monitoring System (2008)

This paper presents a particular methodology to monitor the level of vigilance of an operator in the context of a complex human-machine system. The apparatus consider the instrumentation of a car with several sensors and HMI equipment, developed within the European project SENSATION . We present the SENSATION sensors used in this experiment, the methodology to monitor the level of vigilance and the Human Machine Interface (HMI). For the evaluation of this methodology some experiments were carried-out with car drivers in an on-road condition. Experiments show promising results for a reliable driver’s monitoring systems.
Feedback regulation is central to Delta-Notch signalling required for <i>Drosophila</i> wing vein morphogenesis (1997)

Delta and Notch are required for partitioning of vein and intervein cell fates within the provein during Drosophila metamorphosis. We find that partitioning of these fates is dependent on Delta-mediated signalling from 22 to 30 hours after puparium formation at 25 degrees C. Within the provein, Delta is expressed more highly in central provein cells (presumptive vein cells) and Notch is expressed more highly in lateral provein cells (presumptive intervein cells). Accumulation of Notch in presumptive intervein cells is dependent on Delta signalling activity in presumptive vein cells and constitutive Notch receptor activity represses Delta accumulation in presumptive vein cells. When Delta protein expression is elevated ectopically in presumptive intervein cells, complementary Delta and Notch expression patterns in provein cells are reversed, and vein loss occurs because central provein cells are unable to stably adopt the vein cell fate. Our findings imply that Delta-Notch signalling exerts feedback regulation on Delta and Notch expression during metamorphic wing vein development, and that the resultant asymmetries in Delta and Notch expression underlie the proper specification of vein and intervein cell fates within the provein.
A Solvent-Stable Nanocrystal-Silica Composite Laser (2006)

We have developed a photostable nanocrystal-silica (NC-silica) laser that is robust under different chemical environments, making it suitable for integration with a microfluidic network. We demonstrate that the optical properties of this microscale laser can be a dynamic function of its local environment, thus providing a platform for potential applications such as nonlinear optical chemosensing on a miniaturized scale.
Multidrug Resistance in <i>Salmonella enterica</i> Serotype Typhimurium from Humans in France (1993 to 2003) (2006)

The aim of this study was to determine the distribution of the antimicrobial resistance phenotypes (R types), the phage types and XbaI-pulsed-field gel electrophoresis (PFGE) types, the genes coding for resistance to beta-lactams and to quinolones, and the class 1 integrons among a representative sample of Salmonella enterica serotype Typhimurium isolates collected from humans in 2002 through the French National Reference Center for Salmonella (NRC-Salm) network. The trends in the evolution of antimicrobial resistance of serotype Typhimurium were reviewed by using NRC-Salm data from 1993, 1997, 2000, and 2003. In 2002, 3,998 isolates of serotype Typhimurium were registered at the NRC-Salm among 11,775 serotyped S. enterica isolates (34%). The most common multiple antibiotic resistance pattern was resistance to amoxicillin, chloramphenicol, streptomycin and spectinomycin, sulfonamides, and tetracycline (ACSSpSuTe R type), with 156 isolates (48.8%). One isolate resistant to extended-spectrum cephalosporins due to the production of TEM-52 extended-spectrum beta-lactamase was detected (0.3%), and one multidrug-resistant isolate was highly resistant to ciprofloxacin (MIC > 32 mg/liter). We found that 57.2% of the isolates tested belonged to the DT104 clone. The main resistance pattern of DT104 isolates was R type ACSSpSuTe (83.2%). However, evolutionary changes have occurred within DT104, involving both loss (variants of Salmonella genomic island 1) and acquisition of genes for drug resistance to trimethoprim or to quinolones. PFGE profile X1 was the most prevalent (74.5%) among DT104 isolates, indicating the need to use a more discriminatory subtyping method for such isolates. Global data from the NRC-Salm suggested that DT104 was the main cause of multidrug resistance in serotype Typhimurium from humans from at least 1997 to 2003, with a roughly stable prevalence during this period.
Thermoelastic properties of crosslinked polyurethanes (1979)

Abstract Thermoelastic (stress–temperature) measurements in elongation have been carried out on polyurethane elastomers obtained from poly(ethylene adipate), poly(ethylene maleate), poly(ethylene glycol), and 4,4′‐diphenylmethane diisocyanate. The elastomers were crosslinked by an excess of diisocynate and some of them were additionally crosslinked by dicumyl peroxide. Values of the temperature coefficient d ln r / dT of the unperturbed dimensions of the network chains and the fraction f e / f of the stress, which is due to energetic effects, were calculated from measurements of unswollen samples and samples swollen in benzene to a constant volume fraction ν 2 of about 0.6. The coefficient d ln r / dT and the ratio f e / f for unswollen samples were positive but dependent on the extension ratio α and crosslinking density. The f e / f ratio displayed a tendency to decrease with increasing α and this decrease was smaller for elastomers of higher crosslinking density. Additional crosslinking due to dicumyl peroxide reduced the dependence of f e / f on α. Swollen samples had lower positive values of f e / f ; which were somewhat independent of α and crosslinking density. Departures from the molecular theories of rubberlike elasticity are explained by intermolecular effects, which, in general, are influenced by crosslinking.
Oral delivery of nanoparticle urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI (2019)

The popular anticancer drug cisplatin causes many adverse side effects, the most serious of which is acute kidney injury (AKI). Emerging evidence from laboratory and clinical studies suggests that the AKI pathogenesis involves oxidative stress pathways; therefore, regulating such pathways may offer protection. Urolithin A (UA), a gut metabolite of the dietary tannin ellagic acid, possesses antioxidant properties and has shown promise in mouse models of AKI. However, therapeutic potential of UA is constrained by poor bioavailability. We aimed to improve oral bioavailability of UA by formulating it into biodegradable nanoparticles that use a surface-conjugated ligand targeting the gut-expressed transferrin receptor. Nanoparticle encapsulation of UA led to a sevenfold enhancement in oral bioavailability compared with native UA. Treatment with nanoparticle UA also significantly attenuated the histopathological hallmarks of cisplatin-induced AKI and reduced mortality by 63% in the mouse model. Expression analyses indicated that nanoparticle UA therapy coincided with oxidative stress mitigation and downregulation of nuclear factor erythroid 2-related factor 2- and P53-inducible genes. Additionally, normalization of miRNA (miR-192-5p and miR-140-5p) implicated in AKI, poly(ADP-ribose) polymerase 1 levels, antiapoptotic signaling, intracellular NAD<sup>+</sup>, and mitochondrial oxidative phosphorylation were observed in the treatment group. Our findings suggest that nanoparticles greatly increase the oral bioavailability of UA, leading to improved survival rates in AKI mice, in part by reducing renal oxidative and apoptotic stress.
The Papillomavirus E2 Proteins: Structure, Function, and Biology (2002)

Nearly twenty years after the first high-resolution crystal structures of specific protein-DNA complexes were determined, the stereo-chemical basis for protein-DNA recognition remains an active area of investigation. One outstanding question is, how are proteins able to detect noncontacted sequences in their binding sites? The papillomavirus E2 proteins represent a particularly suitable group of proteins in which to examine the mechanisms of "indirect readout." Coordinated structural and thermodynamic studies of the E2-DNA interaction conducted over the past five years are summarized in this review. The data support a model in which the electrostatic properties of the individual E2 proteins correlate with their affinities for intrinsically flexible or rigidly prebent DNA targets.
“Minirings” would allow many pi-pi collisions (1971)

A storage device in which particles collide over their entire orbit can be used for pi-pi collision experiments, according to Paul L. Csonka of the University of Oregon. Such devices have been talked about for several years. Csonka's apparatus, which he calls a “miniring,” could, for example, be used with a proposed proton storage ring at the Los Alamos Meson Physics Facility, to give 10 to 70 events per hour. Doing a conventional colliding-beam experiment with two pion beams, one would have to wait ten million years to see an event.
Inhibition of Glutamate:Glyoxylate Aminotransferase Activity in Tobacco Leaves and Callus by Glycidate, an Inhibitor of Photorespiration (1978)

The effect of glycidate (2,3-epoxypropionate), an inhibitor of glycolate synthesis and photorespiration in leaf tissue, was studied on glutamate:glyoxylate and serine:glyoxylate aminotransferases and glycine decarboxylase activities in particulate preparations obtained from tobacco (Nicotiana tabacum L.) callus and leaves. Glycidate specifically and effectively inhibited glutamate:glyoxylate aminotransferase. The inhibition was dependent on glycidate concentration and, to a lesser extent, on substrate concentration. The enzyme was not protected by either substrate. Even with saturating substrate concentrations the glycidate inhibition was only partially reversed. Under the in vitro assay conditions, glycidate inhibition of the aminotransferase was reversible. Glutamate:glyoxylate aminotransferase is the only enzyme of the glycolate pathway thus far examined which is severely inhibited by glycidate. However, in leaf discs, pretreatment with glycidate decreased both glutamate:glyoxylate and serine:glyoxylate aminotransferase activities suggesting binding by glycidate in vivo.Glycidate increased the pool sizes of both glutamate and glyoxylate in leaf discs. It has been shown that increases in concentration of either of these metabolites decrease photorespiration and glycolate synthesis and increase net photosynthesis. It is proposed that glycidate inhibits photorespiration indirectly by increasing the internal concentrations of glutamate and glyoxylate, as a consequence of the inhibition of glutamate:glyoxylate aminotransferase activity.
GABA Promotes Human β-Cell Proliferation and Modulates Glucose Homeostasis (2014)

γ-Aminobutyric acid (GABA) exerts protective and regenerative effects on mouse islet β-cells. However, in humans it is unknown whether it can increase β-cell mass and improve glucose homeostasis. To address this question, we transplanted a suboptimal mass of human islets into immunodeficient NOD-scid-γ mice with streptozotocin-induced diabetes. GABA treatment increased grafted β-cell proliferation, while decreasing apoptosis, leading to enhanced β-cell mass. This was associated with increased circulating human insulin and reduced glucagon levels. Importantly, GABA administration lowered blood glucose levels and improved glucose excursion rates. We investigated GABA receptor expression and signaling mechanisms. In human islets, GABA activated a calcium-dependent signaling pathway through both GABA A receptor and GABA B receptor. This activated the phosphatidylinositol 3-kinase-Akt and CREB-IRS-2 signaling pathways that convey GABA signals responsible for β-cell proliferation and survival. Our findings suggest that GABA regulates human β-cell mass and may be beneficial for the treatment of diabetes or improvement of islet transplantation.
Flip-chip bonded, back-emitting, microlensed arrays of monolithic vertical cavity lasers and resonant photodetectors (2003)

We present flip-chip bonded arrays of monolithically integrated vertical-cavity lasers (VCLs) and resonant photodetectors. The VCLs and photodetectors are integrated using a novel structure that allows through-the-substrate emission and detection without compromising device performance. Substrate-side microlenses have been integrated to take advantage of the through-the-substrate architecture. Flip-chip bonded VCLs exhibit threshold currents as low as 135 /spl mu/A with differential efficiencies of 53%. The detectors have the same operating wavelength as the VCLs and responsivities of 0.48 A/W, corresponding to 60% absorption, with optical bandwidths of 7 nm. The VCLs exhibit maximum small-signal modulation bandwidths, which are limited by parasitics, of /spl sim/9.5 GHz at 20/spl deg/C and /spl sim/8.4 GHz at 70/spl deg/C. The VCLs have the lowest reported bias currents required to reach bandwidths of up to /spl sim/8 GHz. A free-space optical link is demonstrated with these flip-chip bonded arrays of microlensed, monolithically integrated VCLs and detectors. The link is found to be tolerant to temperature differences of /spl plusmn/75/spl deg/C between the VCL and detector, with error free (BER<10/sup -12/) data transmission demonstrated in each case.
Flavonoid and Organic Acid Content in Rose Hips (Rosa L., Sect. Caninae Dc. Em. Christ.) (2012)

Flavonoid content was determined spectrophotometrically, and organic acid concentrations by HPLC. The content of the studied compounds varied greatly. Interspecific differences in the amount of flavonoids and ascorbic acid were highly significant. The most common species, Rosa canina, showed low average content of vitamin C (0.51 g/100 g of dry matter) and flavonoids (41 mg/100 g DM) and high content of citric acid (3.48 g/100 g DM). Ascorbic acid was highest in R. villosa hips (avg. 2.25 g/100 g DM), flavonoids were highest in R. rubiginosa (72 mg/100 g DM), and citric acid was highest in R. tomentosa (4.34 g/100 g DM). Flavonoid level correlated negatively with the amount of citric acid (r=-0.47, p<0.001). Cluster analysis of rose species based on the content of the investigated compounds confirmed the validity of the division of sect. Caninae into three subsections: Rubiginosae, Vestitae and Rubrifoliae. The phytochemical variation of these roses reflects their probable phylogenetic relationships as determined from morphology.
Synthesis, Characterization, and Evaluation of Phosphated Cross-Linked Konjac Glucomannan Hydrogels for Colon-Targeted Drug Delivery (2007)

Hydrogel systems of konjac glucomannan (KGM) cross-linked with trisodium trimetaphosphate (STMP) were prepared for colon-targeting drug delivery. Swelling degrees of the hydrogels were measured in artificial gastrointestinal fluids and in sodium chloride solution with different concentrations to study their dependence on the cross-linking density and the ionic strength. The absorption of methylene blue was used to characterize the degree of the KGM cross-linking. In vitro release of model drug hydrocortisone was studied in presence and absence of beta -mannanase. KGM cross-linked with STMP was able to retard the release of the poorly water-soluble drug and could be biodegraded enzymatically. Hydrocortisone release was cross-linking density dependent and controlled by degradation of the hydrogles.
Thyroid Disease in Adults (2010)

Thyroid disease in adults , Thyroid disease in adults , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
Process for producing 6-(2, 3-dichlorophenyl)-1, 2, 4-triazine 3,5-diamine(Lamotrigine) and identification, characterization of a new N-methyl impurity (2012)

Disclosed herein is the industrial scalable process for producing the 6-(2,3-dichloro-phenyl)- 1,2,4-triazine-3,5-diamine (Lamotrigine) with 99.9% HPLC purity and high yield in neutral conditions as compared to basic and acidic reaction conditions. The major impurities, A, B, C, D, E, F and G, are listed in European & US pharmacopoeias. We are reporting, an investigated and characterized new impurity (N-methyl impurity) and besides a way to control during the process.
ChemInform Abstract: MOLECULAR REQUIREMENTS OF THE ACTIVE SITES OF THE CHOLINERGIC RECEPTORS. XII. ‐METHYL‐2‐OXO‐1‐DIMETHYLAMINOMETHYLCYCLOPENTANE METHIODIDE AS A N W SELECTIVE AGONIST FOR THE NICOTINIC RECEPTOR (1980)

To investigate further the nature of the active sites of cholinergic receptors, the carbocyclic analogs of isomuscarone and isomuscarine [(IV) and (V a-d)] were synthesized and tested for their cholinergic activity. Like isomuscarines, such compounds are completely devoid of muscarinic activity which further support the hypothesis that the receptor site, corresponding to position 2 of the ring, cannot accept groups larger than and/or with a dipole having a different direction from that of an ether oxygen. On the other hand nicotinic activity is quite good. In this respect compound (IV) is particulary interesting, being as active as ACh and pratically devoid of muscarinic activity.