gebhart/patrepeval huggingface dataset:
Mutations of the N-ras gene in juvenile chronic myelogenous leukemia (1994)

Juvenile chronic myelogenous leukemia (JCML), a myeloproliferative disorder of childhood, is distinct from adult-type chronic myelogenous leukemia (CML) and bears resemblance to chronic myelomonocytic leukemia (CMMoL). Since mutations in the N-ras gene have been found at high frequencies in CMMoL, but only rarely in CML, we analyzed mutations activating the N-ras gene in 20 patients with JCML. We used the strategy for analysis of gene mutations based on in vitro DNA amplification by polymerase chain reaction (PCR) followed by single-strand conformation polymorphism (SSCP) analysis and/or direct sequence analysis. Nucleotide sequence analysis showed single nucleotide substitutions involving codons 12, 13, or 61 in six of 20 patients (30%). Four of six patients with mutations were in chronic phase and the other two in blast crisis, indicating no apparent correlation with disease stage. Most of the patients with mutations were in the older age group with poor prognosis, although one patient in the younger age group also harbored the mutation. These data suggest that N-ras gene mutations may be involved in the pathogenesis and/or prognosis of JCML and provide further evidence that JCML is an entity distinct from CML.
Using Animation to Design, Document and Trace Object-Oriented Systems (1992)

Current diagramming techniques for the development and documentation of object-oriented designs largely emphasize capturing relationships among classes. Such techniques cannot capture full designs because the static nature of class relationships makes them inadequate for describing the dynamics of object collaboration. Other techniques attempt to diagram dynamic behavior but are limited by their media to producing essentially passive description of dynamic operations. What is still needed is a technique that models message ordering, changing visibility and temporal object lifetimes in a manner that is concise and immediate. We have developed an approach in which developers use animation to develop and capture object-oriented designs. This allows developers to design object-oriented scenarios in the way that they visualize them: by animating the actions of the objects in the scenario. The same animation then acts as the documentation for the design. Its playback makes immediately evident the temporal relationship of object messages, object creation, object destruction, and changing object visibility. Our technique is supported as part of a suite of object-oriented development tools we call GROOVE.
Energy Efficiency in the Future Internet: A Survey of Existing Approaches and Trends in Energy-Aware Fixed Network Infrastructures (2010)

The concept of energy-efficient networking has begun to spread in the past few years, gaining increasing popularity. Besides the widespread sensitivity to ecological issues, such interest also stems from economic needs, since both energy costs and electrical requirements of telcos' and Internet Service Providers' infrastructures around the world show a continuously growing trend. In this respect, a common opinion among networking researchers is that the sole introduction of low consumption silicon technologies may not be enough to effectively curb energy requirements. Thus, for disruptively boosting the network energy efficiency, these hardware enhancements must be integrated with ad-hoc mechanisms that explicitly manage energy saving, by exploiting network-specific features. This paper aims at providing a twofold contribution to green networking. At first, we explore current perspectives in power consumption for next generation networks. Secondly, we provide a detailed survey on emerging technologies, projects, and work-in-progress standards, which can be adopted in networks and related infrastructures in order to reduce their carbon footprint. The considered approaches range from energy saving techniques for networked hosts, to technologies and mechanisms for designing next-generation and energy-aware networks and networking equipment.
Time of Nitrogen Application: Effects on Winter Wheat and Residual Soil Nitrate (1995)

Abstract Rate and time of N fertilizer application can affect winter wheat ( Triticum aestivum L.) forage and grain yield and quality, and may influence residual NO 3 ‐N concentration and distribution in the soil profile. Objectives of this experiment were to determine the effects of N fertilizer rate and time of application on forage and grain yield, N uptake, and distribution of residual soil NO 3 ‐N. Field experiments were conducted for four consecutive years on a Teller sandy loam (fine‐loamy, mixed, thermic Udic Argiustoll) cropped to winter wheat under conventional tillage. Urea‐ammonium nitrate (UAN) was broadcast and incorporated before planting (PPI) or topdressed in December (Feekes 3), January (late Feekes 3), February (Feekes 4), or March (Feekes 5–6) at rates of 34, 67, 101, and 134 kg N ha −1 . Soil samples were taken from each plot after each grain harvest to 1.2 m and analyzed for NH 4 ‐N and NO 3 ‐N. Forage yield response (measured in late March to mid‐April) to January and December N application was comparable to PPI when adequate precipitation was received after N was applied. Applying N in February and March resulted in plant tissue damage and lower forage yields due to less early‐season growth than with other applications. Apparent fertilizer N recovery in forage was highest when N was applied at or before mid‐January. Date of N application had minimal influence on grain yields. Quadratic response surface models suggest the optimum time of N application for maximum forage and grain yields to be mid‐November and early January, respectively. Timing of N application had no effect on residual NH 4 ‐N and little influence on residual NO 3 ‐N concentration and distribution in the soil profile at the end of each cropping cycle.
Modeling and simulation of airship logistics heavy lift for military applications (2010)

BACKGROUND: The critical role of thioredoxin-interacting protein (TXNIP) in cellular sulfhydryl redox homeostasis and inflammasome activation is already widely known, however, no pan-cancer analysis is currently available. METHODS: We thus first explored the potential roles of TXNIP across thirty-three tumors mainly based on The Cancer Genome Atlas and Gene Expression Omnibus datasets. RESULTS: TXNIP is lowly expressed in most cancers, and distinct associations exist between TXNIP expression and the prognosis of tumor patients. TXNIP expression was associated with tumor mutational burden, microsatellite instability, mismatch repair genes, tumor infiltrating immune cell abundance as well as cancer-associated fibroblasts. Moreover, ubiquitin mediated proteolysis, protein post-translational modification and other related pathways were involved in the functional mechanisms of TXNIP. CONCLUSIONS: Our first pan-cancer study comprehensively revealed the carcinostatic role of TXNIP across different tumors. And this molecule may be considered as a potential immunological and prognostic biomarker. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12935-022-02639-2.
A Revised Questioning Technique in Lie-Detection Tests (1947)

(The author of this article, a member of the staff of the Chicago Police Scientific Crime Detection Laboratory, has had extensive experience in lie-detection examination of criminal suspects and witnesses. He has made two noteworthy contributions to the field of scientific lie detection, the first of which was described in a previous number of this Journal. See Simulated Blood Pressure Responses in Lie-Detection Tests and a Method for Their Detection, 36 (3) :201 (1945). The present paper describes Mr. Reid's second and equally important contribution.-EDITOR.)
Miniaturized, light-adaptive, wireless dosimeters autonomously monitor exposure to electromagnetic radiation (2019)

Exposure to electromagnetic radiation (EMR) from the sun and from artificial lighting systems represents a modifiable risk factor for a broad range of health conditions including skin cancer, skin aging, sleep and mood disorders, and retinal damage. Technologies for personalized EMR dosimetry could guide lifestyles toward behaviors that ensure healthy levels of exposure. Here, we report a millimeter-scale, ultralow-power digital dosimeter platform that provides continuous EMR dosimetry in an autonomous mode at one or multiple wavelengths simultaneously, with time-managed wireless, long-range communication to standard consumer devices. A single, small button cell battery supports a multiyear life span, enabled by the combined use of a light-powered, accumulation mode of detection and a light-adaptive, ultralow-power circuit design. Field studies demonstrate single- and multimodal dosimetry platforms of this type, with a focus on monitoring short-wavelength blue light from indoor lighting and display systems and ultraviolet/visible/infrared radiation from the sun.
Generation of optical waveforms in 1.3-μm SOA-based fiber lasers (2011)

Passive optical waveform generation is obtained in fiber lasers using a 1.3-μm semiconductor optical amplifier (SOA) as the gain medium. Various waveforms, including square wave, staircase wave, triangular wave, pulse, and dark pulse are generated in SOA-based fiber lasers by adjusting intracavity polarization controllers. The passive waveform generation might be attributed to the SOA gain dynamics and the enhanced nonlinear interaction at the 1.3-μm zero dispersion wavelength of traditional single-mode fiber (SMF), as well as the interference effect between the two sub-cavities of fiber laser. With figure-8 cavity configuration, 1250th-order harmonic pulses have been successfully demonstrated. We have also obtained a free-running SOA-based fiber laser with 3-dB spectral width of 16 nm, and the center wavelength can be tuned over 45 nm range.
Site-Specific Antiatherogenic Effect of the Antioxidant Ebselen in the Diabetic Apolipoprotein E–Deficient Mouse (2009)

Ebselen reduces atherosclerotic lesions in most regions of diabetic apoE(-/-) aorta, except within the aortic sinus, suggesting its effectiveness as a potential antiatherogenic therapy in diabetic-macrovascular disease. Ebselen may elicit its effect via modulation of transcription factors such as NF-kappaB and AP-1.
Speech enhancement based on auditory spectral change (2002)

In this paper, an adaptive approach to the enhancement of speech signals is developed based On auditory spectral change. The algorithm is motivated by sensitivity of aural, biologic systems to signal dynamics, by evidence that noise is aurally masked by rapid changes in a signal, and by analogies to these two aural phenomena in biologic visual processing. Emphasis is on preserving nonstationarity, i.e., speech transient and time-varying components, such as plosive bursts, formant transitions, and vowel onsets, while suppressing additive noise. The essence of the enhancement technique is a Wiener :filter that uses a desired signal spectrum whose estimation adapts to stationarity of the measured signal. The degree of stationarity is derived from a signal change measurement, based on an auditory spectrum that accentuates change in spectral bands, The adaptive filter is applied in an unconventional overlap-add analysis/synthesis framework, using a very short 4-ms analysis Window and a 1-ms frame interval. In informal listening the reconstructions are judged to be “crisp” corresponding to good temporal resolution of transient and rapidly-moving speech events.
Radiated emission from shielded cables by pigtail effect (1992)

Theoretical analyses and experimental results are carried out on the common mode radiated emission from a shielded cable caused by pigtails. Calculations of the radiation are introduced on the basis of transmission line theory and antenna theory, and are in excellent agreement with the experiment. Certain protective methods and techniques are presented, which exhibit at least 30-dB suppressions against the pigtail effect.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Computing Machine Based on Tree Structures (1971)

The expenditure of resources to provide via software more structure and more function in conventional machines has become excessive. The answer to this problem may consist in providing more structure and more function in hardware. With respect to structure, we describe 1) the binary tree as basic data and control structure, 2) the implementation of a binary tree by a conventional memory, and 3) the associated hardware. The most important enhancement with respect to function, the newly introduced unit of action, deals with the handling of variables and substitution.
Modeling the economic value of a Chagas’ disease therapeutic vaccine (2012)

The health burden of Chagas' disease (resulting from Trypanosoma cruzi infection) in Latin America (estimated to outweigh that of malaria by 5-fold and affect 2-6 million people in Mexico alone) has motivated development of therapeutic vaccines to prevent infection progression to severe disease. Our economic model for a Chagas' therapeutic vaccine in Mexico suggests that a vaccine would be highly cost-effective and in many cases economically dominant (providing both cost savings and health benefits) throughout a range of protection durations, severe adverse event risk, and dosing regimens and would be most likely to provide a positive return on investment if the vaccine prevented (rather than delayed) the onset of cardiomyopathy.
Were monocytes responsible for initiating the cytokine storm in the TGN1412 clinical trial tragedy? (2010)

The precise biological mechanisms that caused the TGN1412 clinical trial tragedy (also known as 'The Elephant Man Clinical Trial') in March 2006 remain a mystery to this day. It is assumed widely that the drug used in this trial (TGN1412) bound to CD28 on T lymphocytes and following activation of these cells, a massive 'cytokine storm' ensued, leading ultimately to multi-organ failure in all recipients. The rapidity of this in vivo response (within 2 h), however, does not fit well with a classical T lymphocyte response, suggesting that other 'faster-acting' cell types may have been involved. In this study we have activated purified human peripheral blood leucocyte populations using various clones of mouse monoclonal anti-CD28 presented to cells in the form of a multimeric array. Cytokines were measured in cell-free supernatants at 2 h, and specific mRNA for tumour necrosis factor (TNF)-α, thought to be the initiator of the cytokine storm, was also measured in cell lysates by reverse transcription-polymerase chain reaction (RT-PCR). Monocytes were the only cell type found to show significant (P < 0·05) up-regulation of TNF-α at 2 h. Eleven other monocyte cytokines were also up-regulated by anti-CD28 within this time-frame. It therefore seems likely that monocytes and not T cells, as widely believed, were probably responsible, at least in part, for initiating the cytokine storm. Furthermore, we propose that a multimeric antibody array may have formed in vivo on the vascular endothelium via an interaction between TGN1412 and CD64 (FcγRI), and we provide some evidence in support of this hypothesis.
Shared Epitope–Antagonistic Ligands: A New Therapeutic Strategy in Mice With Erosive Arthritis (2015)

These findings identify calreticulin as a novel therapeutic target in erosive arthritis and provide sound rationale and early structure/activity relationships for future drug design.
Strong, Rapid Binding of a Platinum Complex to Thymine and Uracil Under Physiological Conditions (1997)

Novel chelate ring-opening occurs when cytotoxic bis(aminoethylphosphanyl)platinum(II) binds rapidly to the N3 atom of the DNA base thymine (T) and RNA base uracil (U) at pH 7 in the presence of chloride ions (depicted on the right). This is in contrast to cisplatin, which shows little binding to thymine or uracil under similar conditions, and thus opens the possibility for base-specific attack on DNA and RNA.
Combining Kanban and Scrum -- Lessons from a Team of Sysadmins (2012)

In 2010 the author had an opportunity to work with a team of fantastically intelligent system administrators. Their team dynamics and project was completely different from software projects the author have worked with before. We have tried Scrum which did not work at all due to too unstable environment. We also failed using Kanban because of the lack of boundaries, which led to coming back to guerilla-style work. Over time we have learnt that it is advised to draw as much as you can from Scrum into Kanban to make it easy and sustainable for long. The team came up with a Scrum and Kanban hybrid which is suitable for teams with high level of maintenance and ad-hoc work.
Immunohistochemical Demonstration of 15-Lipoxygenase in Transplant Coronary Artery Disease (1995)

15-Lipoxygenase (15-LO) catalyzes the oxygenation of arachidonic and linoleic acids and has been implicated in the oxidative modification of low-density lipoproteins (LDL). 15-LO mRNA and protein have previously been demonstrated in macrophages of rabbit and human atherosclerotic lesions. The purpose of this study was to investigate whether 15-LO is also present in the accelerated form of coronary artery disease that can complicate cardiac transplantation (TCAD). Immunohistochemical analysis of coronary arteries with TCAD was carried out by using a rabbit polyclonal antibody raised against human recombinant 15-LO and an avidin-biotin-immunoperoxidase system. Normal coronary and pulmonary arteries showed no immunostaining for 15-LO. Two different types of TCAD were observed. One type consisted of concentric intimal proliferation of smooth muscle cells, without lipid or calcium deposits. No immunoreactivity for 15-LO was present in these lesions. The second type of graft arteriosclerosis consisted of complex atheromatous lesions, containing myointimal cells, lipid-laden foam cells, fragmented internal elastic laminae, and calcifications. 15-LO immunostaining of myointimal cells, lipid-laden foam cells, and endothelial cells was consistently present in these atheromatous lesions. The majority of the myointimal and foam cells positive for 15-LO were recognized by antisera to alpha-smooth muscle actin; the others were identified as macrophages. The results indicate that 15-LO expression is present in endothelial, myointimal, and foam cells in complex atheromatous lesions of TCAD, and suggest that 15-LO may play a role in the pathogenesis of this form of the disease.
Chemotactic activity of soluble Fas ligand against phagocytes. (1998)

A recombinant soluble form of human Fas ligand (sFasL) was tested for its chemotactic activity against human and mouse polymorphonuclear neutrophils (PMN) by the Boyden chamber method. sFasL exhibited a potent chemotactic activity against both human and mouse PMN and HL-60 cells when differentiated into neutrophils or monocytes. A neutralizing anti-FasL mAb abolished the chemotactic activity, while control mAb did not. Ligation of Fas by either IgM- or IgG-type anti-Fas mAb also induced PMN migration. PMN derived from lpr mice that express few Fas molecules did not respond to sFasL. In contrast, those derived from lpr(cg) mice that express Fas molecules with a mutated death domain normally responded to sFasL chemotaxis. These results directly indicated a chemotactic activity of sFasL against PMN and suggest a novel signaling function of Fas, which appears to be independent of the death domain-mediated apoptosis.
Introduction (1993)

Journal Article Introduction Get access Sydney M. Finegold Sydney M. Finegold Editor Search for other works by this author on: Oxford Academic PubMed Google Scholar Clinical Infectious Diseases, Volume 16, Issue 5, May 1993, Page 597, https://doi.org/10.1093/clind/16.5.597 Published: 01 May 1993
Condition monitoring of high voltage transformer oils using optical chromaticity (2014)

The motivation for the present contribution was to produce a cost effective, convenient system for the optical monitoring of degraded high voltage transformer oils using the chromaticity of polychromatic light transmitted through the oil. The technique uses readily available and portable instrumentation. Examples of results for typical oil samples have been obtained with the technique and comparisons made with the conventional technique of Colour Index. It is shown how the chromatic technique can supplement the Colour Index approach to provide additional information about changes in the transformer oil, such as the presence and extent of solid micro-particles.
A 7 k-pixel×3 line color linear sensor with single-side readout method (1995)

A 7 k-pixel/spl times/3 line color linear sensor has been developed for color image scanners. The sensor pitch, 8 /spl mu/m, is the smallest size among devices with a single-sided readout method. A wide blooming margin and dynamic range is achieved. A gain-select function and a shutter function is adopted. This sensor reads A4-size documents at a density of 800 DPI.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Brown Norway Rat as a Model of Male Reproductive Aging: Evidence for Both Primary and Secondary Testicular Failure (1994)

In man, aging is associated with both primary and secondary testicular dysfunction. In contrast, most studies in male rat models of aging have demonstrated only secondary testicular failure. We previously reported that testes from aging male F344 rats secrete excessive progesterone (P), which may suppress gonadotropin secretion and confound aging studies. To determine whether the male Brown Norway (BN) rat is a more suitable aging model, trunk blood was collected from intact (sham-operated) and orchidectomized young (3 mo), middle-aged (13 mo), old (23 mo), and senescent (28-30 mo) animals. Testosterone (T), estradiol (E2), P, prolactin (PRL), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured by RIA. In intact rats, T levels declined with aging, while LH was unchanged, and FSH increased progressively with aging. In contrast to F344 rats, no age-related increases in P or E2 occurred, nor did PRL or other steroid hormones increase. In the absence of testicular feedback (orchidectomized rats), FSH and LH declined progressively with aging. These findings suggest that, as in men, aging male BN rats manifest both primary and secondary testicular failure, and do not exhibit decreased gonadotropin levels secondary to excessive steroid or PRL secretion. Therefore, the BN rat appears to be the best available rat model for studies of male reproductive aging.
Pulse width controlled resistivity switching at room temperature in Bi0.8Sr0.2MnO3 (2009)

We report pulsed as well as direct current/voltage induced electroresistance in Bi0.8Sr0.2MnO3 at room temperature. It is shown that bilevel and multilevel resistivity switching can be induced by a sequence of pulses of varying pulse width at a fixed voltage amplitude. Resistivity increases abruptly (≈55% at 300 K) upon reducing pulse width from 100 to 25 ms for a fixed electric field (E=2 V/cm2) of 200 ms pulse period. The resistivity switching is accompanied by a periodic change in temperature, which alone cannot explain the magnitude of the resistivity change.
Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis (2015)

Pharmacological ASBT inhibition attenuates cholestatic liver and bile duct injury by reducing biliary BA concentrations in mice.