gebhart/patrepeval huggingface dataset:
Enantioselective synthesis of the 1.beta.-methylcarbapenems via cycloaddition of 3-siloxypentadiene and 4-acetoxyazetidinone (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantioselective synthesis of the 1.beta.-methylcarbapenems via cycloaddition of 3-siloxypentadiene and 4-acetoxyazetidinoneThomas J. Sowin and A. I. MeyersCite this: J. Org. Chem. 1988, 53, 17, 4154–4156Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/jo00252a067https://doi.org/10.1021/jo00252a067research-articleACS PublicationsRequest reuse permissionsArticle Views301Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Research of network storage system based on erasure code (2011)

Data availability is one of the most important properties of the network storage system. Data redundancy is the basic method to improve data availability. Thus some systems use replication to protect against data loss. This paper designs a network storage system based on erasure code, researches data place strategy and data read write operation flow, analyzes data availability and storage overhead of the erasure code strategy and the replication strategy, draws the conclusion that erasure code strategy can greatly improve data availability.
Domain-speciﬁc query translation for multilingual accessto digital libraries (2009)

Accurate high-coverage translation is a vital component of reliable cross language information access (CLIR) systems. This is particularly true of access to archives such as Digital Libraries which are often speciﬁc to certain domains. While general machine translation (MT) has been shown to be effective for CLIR tasks in information retrieval evaluation workshops, it is not well suited to specialized tasks where domain speciﬁc translations are required. We demonstrate that effective query translation
in the domain of cultural heritage (CH) can be achieved by augmenting a standard MT system with domain-speciﬁc phrase dictionaries automatically mined from the online Wikipedia. Experiments using our hybrid translation system with sample query logs from users of CH websites demonstrate a large improvement in the accuracy of domain speciﬁc phrase detection and translation.
HDL <sub>3</sub> Induces Cyclooxygenase-2 Expression and Prostacyclin Release in Human Endothelial Cells Via a p38 MAPK/CRE-Dependent Pathway: Effects on COX-2/PGI-Synthase Coupling (2004)

We conclude that in endothelial cells, HDL modulates COX-2/PGI-S activity via both p38 MAPK-dependent COX-2 mRNA stability and transcription and both caveolin-1-dependent PGI-synthase shuttling and COX-2 coupling. The understanding of these mechanisms may provide new insights into the antiatherogenic role of HDL.
Improved answer ranking in social question-answering portals (2011)

Community QA portals provide an important resource for non-factoid question-answering. The inherent noisiness of user-generated data makes the identification of high-quality content challenging but all the more important. We present an approach to answer ranking and show the usefulness of features that explicitly model answer quality. Furthermore, we introduce the idea of leveraging snippets of web search results for query expansion in answer ranking. We present an evaluation setup that avoids spurious results reported in earlier work. Our results show the usefulness of our features and query expansion techniques, and point to the importance of regularization when learning from noisy data.
Parallel demodulation of multidimensional signals (1992)

The design of constellations that allow a high degree of parallelism in the staged decoder structure and in addition allow soft decoding of the component algebraic codes based on a systolic algorithm amenable to VLSI implementation is considered. Combination of these multidimensional constellations with trellis-coded modulation (TCM) is also considered. Set partitioning is based on the partition of a linear code into a subcode and its cosets, and the author shows that a highly parallel demodulator structure can also be applied when TCM is used.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Paenibacillus azoreducens sp. nov., a synthetic azo dye decolorizing bacterium from industrial wastewater. (2001)

An azo-dye-reducing, endospore-forming bacterium isolated from textile industry wastewater has been taxonomically studied. Particularly interesting was the ability of this organism to decolorize the azo dye Remazol Black B by 98% within 24 h. Levels of 16S rRNA similarity between the isolate and Paenibacillus species ranged from 92.1 to 95.0%. The DNA G+C content was 46.8 mol % and anteiso-branched C15:0 was the major fatty acid. Based upon the phenotypic properties and the phylogenetic inference, it is proposed that the bacterium should be designated Paenibacillus azoreducens sp. nov. The type strain of Paenibacillus azoreducens is CM1T (= DSM 13822T = NCIMB 13761T).
Hepatoprotective and Anti-fatigue Effects of Lactic Acid Bacteria (Lactobacillus acidophilus, Bifidobacterium bifidum and Streptococcus thermophilus) (2007)

This study was carried out to investigate the effect of LAB (Lactic acid bacteria: Lactobacillus acidophilus, Bifidobacterium bifidum and Streptococcus thermophilus) on detoxication of damaged liver in carbon tetrachloride (<TEX>$CCl_4$</TEX>) and ethanol (25%)-treated rats. Rats had been daily (twice a day) pre-treated with saline (0.5 ml/kg: untreated group), <TEX>$CCl_4$</TEX> (0.5 ml/kg: other groups) for 6 days. At seventh day, after treating rat with <TEX>$CCl_4$</TEX> and then, mixture of LAB (<TEX>$10^{11}$</TEX>/0.5 ml: LAB group), saline (0.5 ml/kg: untreated group, <TEX>$CCl_4$</TEX> group), and biphenyl dimethyl dicarboxylate (DDB) (50 mg/kg: DDB group) were treated orally with <TEX>$CCl_4$</TEX> for 8 days. Ethanol is treated as the same manner instead of <TEX>$CCl_4$</TEX>. To investigate the hepatoprotective effect, rats treated with <TEX>$CCl_4$</TEX> and ethanol were analyzed with serum GOT and GPT level. The GOT and GPT levels of LAB group was lower than the level of <TEX>$CCl_4$</TEX> and DDB group. Especially, compared with data of <TEX>$CCl_4$</TEX> group, GPT activity showed statistically significant result in the significance level of p < 0.05. The LAB group treated with ethanol also showed lower level of GOT and GPT than the other control groups treated with ethanol. The triglyceride level of serum decreased more in a group treated special materials (DDB and LAB group) than ethanol group. As well, the effect of LAB on the antifatigue has been investigated. The animals (10/group) were divided into 4 groups (untreated group, Carrier group, Red-ginseng group, LAB group). Each group was given carrier (0.9 mg/0.2 ml), red ginseng extract (200 mg/kg), and mixture of LAB (<TEX>$10^{11}$</TEX>/0.2 ml). Special materials were given for three weeks. After finishing treating through oral, horizontal wire test, rotarod test, and forced swimming test were performed. The time of resistance to fatigue of the group, fed with mixture of LAB, was longer than the time when mice treated with red-ginseng that the effect was already revealed. The result of this study revealed that LAB could decrease hepatocelluar injury compared with rats treated orally with <TEX>$CCl_4$</TEX> and ethanol, and could also decrease fatigue.
Glutamate Uptake into Synaptic Vesicles: Competitive Inhibition by Bromocriptine (1989)

The ATP-dependent uptake of L-glutamate into synaptic vesicles has been well characterized, implicating a key role for synaptic vesicles in glutamatergic neurotransmission. In the present study, we provide evidence that vesicular glutamate uptake is selectively inhibited by the peptide-containing halogenated ergot bromocriptine. It is the most potent inhibitor of the agents tested: the IC50 was determined to be 22 microM. The uptake was also inhibited by other ergopeptines such as ergotamine and ergocristine, but with less potency. Ergots devoid of the peptide moiety, however, such as ergonovine, lergotrile, and methysergide, had little or no effect. Although bromocriptine is known to elicit dopaminergic and serotonergic effects, its inhibitory effect on vesicular glutamate uptake was not mimicked by agents known to interact with dopamine and serotonin receptors. Kinetic data suggest that bromocriptine competes with glutamate for the glutamate binding site on the glutamate translocator. It is proposed that this inhibitor could be useful as a prototype probe in identifying and characterizing the vesicular glutamate translocator, as well as in developing a more specific inhibitor of the transport system.
Cryopreservation of Mouse Spermatogonial Stem Cells in Dimethylsulfoxide and Polyethylene Glycol1 (2013)

Assisted reproductive techniques involving isolation, culture, and transplantation of spermatogonial stem cells (SSCs) have the potential to create transgenic livestock and to treat male infertility caused by cancer treatments such as chemotherapy or radiation. Because stem cells may need to be preserved for several years before reintroduction to the patients' testes, efficient SSC cryopreservation techniques need to be developed. SSCs can reinitiate spermatogenesis in recipient testes after freezing; however, optimal cryopreservation protocols have not been identified. The objective of this study was to develop an efficient cryopreservation method for SSCs using permeable cryoprotectant agents (PCAs) or additive cryoprotectant agents (ACAs). To identify an efficient cryopreservation method, populations of mouse testis cells enriched for SSCs were cultured in vitro and frozen using conventional freezing media containing various PCAs or ACAs for 1 wk or 1, 3, 6, 12, or 24 mo. Additionally, various molecular weights and concentrations of polyethylene glycol (PEG) were evaluated. Recovery rate, culture potential, and stem cell activity were significantly greater for cells frozen in 2.5% PEG with a molecular weight of 1000 compared to other treatment groups. These cells also retained the ability to colonize recipient testes, generate normal spermatogenesis, and contribute to viable offspring. The systematic analysis of many cryoprotectant agents indicates that 2.5% PEG (molecular weight 1000) is the most effective agent for efficient SSC cryopreservation.
Rationally Designed Micropores within a Metal−Organic Framework for Selective Sorption of Gas Molecules (2007)

A microporous metal-organic framework, MOF, Cu(FMA)(4,4'-Bpe)0.5 (3a, FMA = fumarate; 4,4'-Bpe = 4,4'-Bpe = trans-bis(4-pyridyl)ethylene) was rationally designed from a primitive cubic net whose pores are tuned by double framework interpenetration. With pore cavities of about 3.6 A, which are interconnected by pore windows of 2.0 x 3.2 A, 3a shows highly selective sorption behaviors of gas molecules.
Eliminating redundancies in sum-of-product array computations (2001)

Array programming languages such as Fortran 90, High Performance Fortran and ZPL are well-suited to scientific computing because they free the scientist from the responsibility of managing burdensome low-level details that complicate programming in languages like C and Fortran 77. However, these burdensome details are critical to performance, thus necessitating aggressive compilation techniques for their optimization. In this paper, we present a new compiler optimization called Array Subexpression Elimination (ASE) that lets a programmer take advantage of the expressibility afforded by array languages and achieve enviable portability and performance. We design a set of micro-benchmarks that model an important class of computations known as stencils and we report on our implementation of this optimization in the context of this micro-benchmark suite. Our results include a 125% improvement on one of these benchmarks and a 50% average speedup across the suite. Also we show a speedup of 32% improvement on the ZPL port of the NAS MG Parallel Benchmark and a 29% speedup over the hand-optimized Fortran version. Further, the compilation time is only negligibly affected.
Turbine Blade Cooling: The Blade Temperature Distribution (2006)

Air cooling of high-temperature gas turbines is a standard practice; the air first cools the blading by internal convection and then by external film cooling, after ejection through holes and slots in the blade surface. In some ‘conventional’ analyses of turbine blade cooling, a ‘standard blade’ is invoked, which has a uniform blade temperature equal to the average temperature of the real blade, and estimates are made of the cooling flow required to hold the standard blade temperature to a limit set by material considerations. However, early analytical work by Ainley (for convective cooling of thin-walled blades) showed that both the coolant and blade temperatures should increase along the blade span. The current paper develops Ainley's original analysis to allow for finite blade wall thickness and thermal barrier coatings, film cooling, and variation in the mainstream gas temperature along the span. This new analysis should enable more accurate estimates to be made of cooling air flow requirements.
Hysteretic response of a nine‐storey reinforced concrete building (1974)

Abstract The Millikan Library on the campus of the California Institute of Technology was strongly shaken during the San Fernando earthquake of 9 February 1971. The building was not damaged structurally, but the observed E‐W response of the building showed a fundamental period of about 1.0 sec, significantly longer than the 0.66 sec observed in pre‐earthquake vibration tests. In this study, the response of the fundamental mode was treated as that of a single‐degree‐of‐freedom hysteretic structure, and four simple models, two stationary and two with changing properties, were examined to see if they could describe the observed response. It was found that an equivalent linear model and a bilinear hysteretic model both could match the response, provided their properties were changed during the earthquake. (Four changes were used.) A linear model with constant properties and a stationary, bilinear hysteretic model did not give nearly as good agreement as the non‐stationary models. The results indicated, in general, a degrading of the stiffness and energy dissipation capacity of the building, with the suggestion that the changes were sudden rather than gradual.
Low-frequency sound generation by an individual open-ocean breaking wave (2001)

Bubble cloud resonances have been proposed as an explanation of the low-frequency acoustic radiation produced by breaking waves. A previous model [H. N. Ogũz, J. Acoust. Soc. Am. 95, 1895–1912 (1994)] considered excitation of the bubble cloud by a rigid piston at the base of a hemispherical bubble cloud. The present model considers excitation of the cloud by individual point sources within the cloud. A Green’s function is obtained for a point source displaced from the origin of a hemispherical bubble cloud beneath a pressure release surface. The method of images and superposition allow one to obtain the field generated by a distribution of point sources within the bubble cloud. The frequency-dependent radiation pattern for two distributions of point sources within the cloud is obtained. Distributing the point sources within the forward sector of the bubble cloud generates spectral characteristics consistent with measured open-ocean breaking wave spectra.
Surgical Removal of a Ventral Brain Stem Cavernous Angioma (1994)

A 21-year-old woman presented with headache, vomiting, dysarthria and mild hemiparesis on the right side. CT scan revealed a round well-circumscribed high density lesion in the ventro-lateral portion of the pons. MRI showed characteristic hemosiderin rim in T2 weighted image. Twelve days after initial bleeding, she developed conscious disturbance, right hemiplegia, MLF syndrome, left abducens and facial palsy. MRI demonstrated the new hematoma extending from the pons to the midbrain. The suboccipital transvermian approach was employed in an attempt to remove the hematoma and the angioma under monitoring of auditory evoked potential. Histological examination revealed abnormal vessels of the cavernous angioma. Surgical indication of the brain stem cavernous angioma is still controversial, especially in a patient with minor neurological deficits. Refinement of neuroradiological procedures and microsurgical technique may bring about favorable results under a more aggressive approach. However, further investigation of the natural history is mandatory in patients with these lesions.
Torsional stability of HA-coated and grit-blasted titanium dental implants. (1992)

Hydroxylapatite (HA)-coated and grit-blasted (non-HA-coated) titanium dental implants were inserted into healed extraction sites of canine mandibles. After six weeks, the animals were killed and the implants mechanically tested in torsion to failure. Interface attachment strength, implant/tissue compatibility, integrity of the HA coating, and the location of interface failure were evaluated. Mechanical testing demonstrated an interface torsional strength of 3.98 +/- 0.93 MPa for the HA-coated implants and 2.25 +/- 0.65 MPa for the grit-blasted implants. This represents a 76.9% improvement in the maximum torsional interface strength, and is statistically-significant (p = 0.0004). On qualitative histologic analysis, interface failure was seen to occur primarily at the HA/implant interface, although failure through the HA coating and regions of bone/HA interface failure were observed. The HA-coated implants had bone in direct apposition to their surface with no fibrous tissue interposition. The grit-blasted implants also had regions of direct bone-implant apposition, but these areas were limited to a smaller proportion of the total interface area. There was no evidence of breakdown or change in thickness of the HA coating.
Keratinocyte lipid fluidity under the influence of cholesterols, hydrocortisones, "active lipid", tocopherol and retinoic acid--a fluorescence polarization study with regard to physiological and pathophysiological epidermopoiesis and its therapeutic accessibility. (1991)

Lipid fluidity of freshly isolated human (H) and guinea pig (GP) keratinocytes (K) was determined as the reciprocal of diphenylhexatriene (DPH) fluorescence polarization (P-value), the temperature being kept at 25 degrees C and cell density standardized to 550,000 per ml (level of statistical significance a less than 0.05). An experimental model involving short-term incubations (2.5 hours, 37 degrees C) of GPK in 1% ethanolic lipid solutions (15 mg lipid agent per ml ethanol) was set up to investigate accumulation a) of cholesterol due to terminal differentiation of keratinocytes and b) of cholesteryl sulfate due to the lack of steroid sulfatase activity in recessive X-linked ichthyosis (RXLI). In comparison to the control including 1% ethanol (P = 0.291 +/- 0.004), significant rigidifying effects were demonstrated for cholesteryl hemisuccinate (0.331 +/- 0.005) and cholesteryl sulfate (0.310 +/- 0.002). Correspondingly, a significant increase of the P-value was also induced by cholesteryl hemisuccinate in HK. Rigidification of GPK by a preincubation with cholesteryl sulfate (P = 0.306 +/- 0.002) could be antagonized by a subsequent short-term incubation with "active lipid (mixture 721)" (0.285 +/- 0.003, a less than 0.05) which may be relevant for future therapeutic strategies in RXLI. Other steran molecules such as hydrocortisone-21-hemisuccinate or hydrocortisone acetate did not affect lipid fluidity. With regard to the therapeutic potency of retinoids in epidermopoietic disorders, incubations of HK with all-trans-retinoic-acid were compared to those with also lipophilic vitamin E, i.e. d-alpha-tocopherol, for 2.5 hours at 37 degrees C using 1% DMSO as a solvent.(ABSTRACT TRUNCATED AT 250 WORDS)
Preparation and characterization of Mitomycin-C loaded chitosan-coated alginate microspheres for chemoembolization (2005)

Mitomycin-C loaded and chitosan-coated alginate microspheres were prepared for use in chemoembolization studies. In this respect, first alginate microspheres were prepared by using a spraying method using an extrusion device with a small orifice and following suspension cross-linking in an oil phase. Chitosan-coating onto the alginate microspheres was achieved by polyionic complex formation between alginate and chitosan. CaCl(2) was used as a cross-linker for alginate microspheres. The obtained chitosan-coated alginate microspheres were spherical shaped and approximately 100-400 microm average size. The microspheres were evaluated based on their swellability and the swelling ratio was changed between 50-280%. CaCl(2) concentration, stirring rate, chitosan molecular weight, chitosan concentration and time for coating with chitosan were selected as the effective parameters on microsphere size and swelling ratio. Equilibrium swellings were achieved in approximately 30 min. On the other hand, chitosan molecular weight, chitosan concentration and time for coating with chitosan were found as the most effective parameters on both drug loading ratio and release studies. Maximum drug loading ratio of 65% was achieved with high molecular weight (HMW) chitosan, highest chitosan concentration (i.e. 1.0% v/v) and shortest time for coating with chitosan (i.e. 1 h) values.
Lumpectomy and Level I Axillary Dissection Prior to irradiation for “Operable” Breast Cancer (1984)

Between July 1, 1979 and March 1, 1984, we treated 154 women by irradiation as an alternative to mastectomy. Excision of the primary tumor without the sacrifice of a large volume of contiguous normal breast (lumpectomy) was performed, and all but ten women also underwent concomitant level I axillary node dissection. The mean node count in the level I dissection was 27 nodes, indicating that this dissection offered accurate information about axillary node status, so that the extent of radiation therapy and subsequent adjuvant chemotherapy could be planned appropriately. Subdivision of the level I nodes into anatomic groups and their separate histologic analysis suggested that less than a complete level I dissection might miss involved nodes in almost one-half the patients with clinically negative axillae but histologically positive nodes. Postoperative complications occurred in 13% of patients, not an insignificant number, most of them being either infections or the persistent accumulation of lymph in the axillary wound. Later complications, such as infection or arm edema, also occurred, just as after mastectomy. The median follow-up of these 154 patients has been only 12 months, the maximum being not quite 5 years, so that any long-term speculations are not justified. We believe that the continued use of this combination therapy is warranted preceding irradiation by lumpectomy and level I axillary dissection as described, with careful follow-up to assess the long-term results of this option.