gebhart/patrepeval huggingface dataset:
DRYING STRATEGIES CAPABLE OF REDUCING THE STRESS LEVEL OF A STACK OF BOARDS AS DEFINED BY A COMPREHENSIVE DUAL SCALE MODEL (2008)

During drying, stresses and deformations develop in a wood board due to shrinkage fi elds which result from moisture content and temperature fi eld variations. In spite of numerous works done in wood drying modelling in the last decades, wood drying optimisation based on modelling and simulation remains far from initial expectations. Two main reasons can explain this assessment: the huge variability of wood and the variations in drying conditions throughout the board stack in a dryer. To address these two key problems, we used a dual scale numerical tool able to compute simultaneously the stress and deformation of hundreds of boards in the stack during drying. A rigorous one-dimensional mechanical formulation, based on previous works, has been used for calculating stress and deformation during drying. The mechanical model is fi tted into a module and then added to a dual scale (boardstack) model. This numerical tool has been used to improve the drying schedules recommended by the Technical Centre for Wood and Furniture in France (CTBA) for spruce. The proposed drying schedules allow the board quality to be improved. Note that the optimisation was limited to medium temperature values, so that the proposed schedule can be applied to conventional kilns.
Alcohol, snoring and sleep apnea. (1982)

We studied the effect of alcohol ingestion on sleep-induced breathing abnormalities and arterial oxyhaemoglobin saturation in seven patients with a range of sleep-induced upper airway occlusion. The characteristics of each patient's sleep-induced breathing abnormality was established on one or more control all-night studies, and then a further all-night study was done immediately following alcohol ingestion. Alcohol increased the duration and frequency of the occlusive episodes in five patients with obstructive sleep apnoea, and resulted in a marked increase in the degree of hypoxaemia in the first hour of sleep. In two patients with benign chronic snoring, alcohol induced frank obstructive sleep apnoea during the first hour of sleep. We suggest that the increased tendency to develop obstructive apnoea after alcohol is the result of alcohol-induced oropharyngeal muscle hypotonia, while the increased duration of obstructive apnea is the result of alcohol-induced depression of arousal mechanisms.
Combining partitioning and global routing in sea-of-cells design (2003)

A report is presented on the partitioning algorithm of a novel automatic layout system for the sea-of-cells design. The algorithm is based on graph partitioning. The principal novelty of the approach is that a global routing is obtained after each iteration to precisely estimate the number of nets crossing a cut. The author also report on the successful application to CMOS chips of the IBM ES/370 chip set.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Murine mesenchymal stem cells isolated by low density primary culture system (2006)

Murine mesenchymal stem cells (mMSC) and the difficult task of isolation and purification of them have been the subject of rather extensive investigation. The present study sought to isolate these cells from two different mouse strains, one outbred and the other inbred, primarily through a relatively simple but novel approach, the most important feature of which was the low density primary culture of bone marrow cells. For this purpose, mononuclear cells from either NMRI or BALB/c bone marrow were plated at about 500 cells per well of 24-well plates and incubated for 7 days. At this point, the fibroblastic clones that had emerged were pooled together and expanded through several subcultures. To investigate the mesenchymal nature, we differentiated the cells into the osteoblastic, chondrocytic and adipocytic lineages in different subcultures up to passage 10. According to the results, 1 week after culture initiation, several clones each comprising several fibroblastic cells appeared in each plate. The cells from different passages were capable of differentiating into corresponding skeletal tissues. In the present investigation, the best culture condition for maximum proliferation and also the expression of certain surface marker on isolated cells were examined. In this term the two murine strains showed some differences.
MEWLANA-mobile IP enriched wireless local area network architecture (2003)

The idea of extending mobile IP capabilities to ad hoc networks introduces fast agent discovery, increases cell coverage of access points, and extends ad hoc network size by providing connection to the Internet. We aim to show that an adaptive protocol is required since different protocols are optimum for different environments. We propose two protocols called MEWLANA-TD and MEWLANA-RD based on DSDV and a novel ad hoc routing called tree based bidirectional routing (TBBR) respectively in addition to the proposed protocols based on on-demand routing. We classify the ad hoc environment into regions and present which protocol is appropriate for which region.
BSA Immobilization on Amine-Functionalized Superparamagnetic Iron Oxide Nanoparticles (2004)

Immobilization of bovine serum albumin (BSA) on surface-modified superparamagnetic iron oxide nanoparticles (SPION) has been performed by two different double-step immobilization approaches. The first approach consists of preparation of SPION by controlled chemical coprecipitation in the presence of BSA solution, whereas the second approach includes preliminary surface modification of SPION with an amine group using a coupling agent of 3-aminepropyltrimethoxysilane (APTMS). Both procedures are followed by 1-ethyl-3-(3-dimethylaminepropyl) carbodiimide hydrochloride (EDC) activation with sequential immobilization of the layer of BSA. Additionally, an attempt to modify the surface of SPION with amine and carboxylic groups is undertaken by using l-aspartic acid (LAA). TEM shows that the particle size varies in the range 10−15 nm and does not change significantly after the coating process. The presence of BSA and amine groups on the surface of SPION is confirmed by FT-IR. Magnetic properties are investigated by VSM and results indicate that the superparamagnetic properties are retained for BSA-coated SPION while reducing the value of saturation magnetization (Ms). The binding capacity is estimated from thermogravimetric and chemical analyses. APTMS-coated SPION show higher BSA binding capacity compared to that of coprecipitated SPION in the presence of BSA. In vitro tests have been performed after the functionalization of SPION with LAA and BSA. Human dermal fibroblasts are incubated with the surface-modified SPION for 6 and 24 h to observe cell behavior, morphology, cytoskeletal organization, and interactions between cell and SPION. BSA-coated SPION incubated with cells demonstrated a cell response similar to that of control cells, with no adverse cell damage and no endocytosis, whereas LAA-coated SPION show partial endocytosis without cytoskeletal disorganization.
Force spectroscopy of polymer desorption: theory and molecular dynamics simulations (2014)

Forced detachment of a single polymer chain, strongly adsorbed on a solid substrate, is investigated by two complementary methods: a coarse-grained analytical dynamical model, based on the Onsager stochastic equation, and Molecular Dynamics (MD) simulations with a Langevin thermostat. The suggested approach makes it possible to go beyond the limitations of the conventional Bell-Evans model. We observe a series of characteristic force spikes when the pulling force is measured against the cantilever displacement during detachment at constant velocity vc (displacement control mode) and find that the average magnitude of this force increases as vc increases. The probability distributions of the pulling force and the end-monomer distance from the surface at the moment of the final detachment are investigated for different adsorption energies ε and pulling velocities vc. Our extensive MD simulations validate and support the main theoretical findings. Moreover, the simulations reveal a novel behavior: for a strong-friction and massive cantilever the force spike pattern is smeared out at large vc. As a challenging task for experimental bio-polymer sequencing in future we suggest the fabrication of a stiff, super-light, nanometer-sized AFM probe.
Oxidation of linoleic acid encapsulated with gum arabic or maltodextrin by spray-drying (2002)

Linoleic acid was emulsified with gum arabic or maltodextrin at various weight ratios of the acid to the polysaccharide in the presence or absence of a small-molecule emulsifier. The emulsions were spray-dried to produce microcapsules. Emulsions prepared with gum arabic were smaller in droplet size and more stable than those prepared with maltodextrin, and linoleic acid in a gum arabic-based microcapsule was also most resistant to oxidation than that in a maltodextrin-based microcapsule. Although the oil droplet size in the emulsion with maltodextrin decreased and the emulsion stability was improved by addition of a small-molecule emulsifier to linoleic acid, the oxidative stability of the encapsulated linoleic acid was not significantly improved. Encapsulated linoleic acid of small droplet size oxidized more slowly than that of large droplet size.
Separation of Switchgrass Bio-Oil by Water/Organic Solvent Addition and pH Adjustment (2016)

Applications of bio-oil are limited by its challenging properties including high moisture content, low pH, high viscosity, high oxygen content, and low heating value. Separation of switchgrass bio-oil components by adding water, organic solvents (hexadecane and octane), and sodium hydroxide may help to overcome these issues. Acetic acid and phenolic compounds were extracted in aqueous and organic phases, respectively. Polar chemicals, such as acetic acid, did not partition in the organic solvent phase. Acetic acid in the aqueous phase after extraction is beneficial for a microbial-electrolysis-cell application to produce hydrogen as an energy source for further hydrodeoxygenation of bio-oil. Organic solvents extracted more chemicals from bio-oil in combined than in sequential extraction; however, organic solvents partitioned into the aqueous phase in combined extraction. When sodium hydroxide was added to adjust the pH of aqueous bio-oil, organic-phase precipitation occurred. As the pH was increased, a biphasic aqueous/organic dispersion was formed, and phase separation was optimized at approximately pH 6. The neutralized organic bio-oil had approximately 37% less oxygen and 100% increased heating value than the initial centrifuged bio-oil. The less oxygen content and increased heating value indicated a significant improvement of the bio-oil quality through neutralization.
Application of Ground/Air Data Link to General Aviation Operations (1987)

The Federal Aviation Administration (FAA) is currently upgrading secondary surveillance radars with systems which will have an integral data link capability, the Mode Select (Mode S) beacon system. These new systems will allow two-way data communications between ground systems (e.g., weather databases and Air Traffic Control (ATC) systems) and aircraft that are equipped with data link compatible Mode S transponders and suitable display and input devices. Initial data link services include both weather information and ATC advisories. The MITRE Corporation* is developing an in-house capability to perform end-to-end operational evaluation of data link services. Initially, a low-cost, portable pilot position man-machine interface is being developed for use in general aviation operations. The objective is to explore operational issues in laboratory and limited flight test environments, and to demonstrate these services on a data link I/O device, a laptop portable personal computer (PC) with touch panel. A group of pilots will bench test the interface design, and the results will be incorporated into the design used in flight testing. This paper describes the project's objectives and results to date, including implementation details and pilot test results.
Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. (1998)

Barrett's esophagus is a premalignant condition arising in response to chronic reflux esophagitis. Inducible nitric oxide synthase (iNOS; NOS-2) and cyclooxygenase-2 (COX-2) are mediators of inflammation and regulators of epithelial cell growth. Expression levels of iNOS and COX-2 are high in colorectal adenomas and carcinomas, and COX-2 expression is elevated in gastric cancers. To determine the involvement of iNOS and COX-2 in Barrett's-associated neoplasia, we measured expression of these genes in metaplastic Barrett's and esophageal adenocarcinomas. We detected elevated iNOS and COX-2 mRNA levels in Barrett's mucosa compared with paired gastric control tissues in 16 of 21 (76%) and 17 of 21 (80%) patients, respectively (P < 0.001 for both genes). In esophageal adenocarcinomas, iNOS and COX-2 mRNA levels were increased in four of five and five of five cases, respectively. Furthermore, in 10 of 10 Barrett's patients, immunohistochemical staining for iNOS and COX-2 expression was strongly positive and higher than in matched gastric controls. Increased COX-2 expression was confirmed by Western blotting. These findings support the hypothesis that iNOS and COX-2 are involved early and often in Barrett's-associated neoplastic progression.
Reagent that restores galactose-1-phosphate uridylyltransferase activity in dry blood spots. (1987)

Journal Article Reagent that restores galactose-1-phosphate uridylyltransferase activity in dry blood spots. Get access H K Berry, H K Berry Search for other works by this author on: Oxford Academic Google Scholar C C Croft C C Croft Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 33, Issue 8, 1 August 1987, Pages 1471–1472, https://doi.org/10.1093/clinchem/33.8.1471 Published: 01 August 1987
Six Models of Community Intervention: A Dialectical Synthesis of Social Theory and Social Action (1990)

Two dominant theoretical perspectives-systems theory and conflict theory-underlie major approaches to community intervention. This paper presents a conceptual linkage between models of intervention for planning and organizing as developed by Rothman and elaborated by Stockdale and major sociological theories of society. Two additional models are presented to address issues of management and administration. The six models are integrated into a typology which integrates the conflict and consensus theories of society in relation to the six strategies. The result is a synthesis of six models for community engagement which is rooted in dialectically opposed theories of society, and which addresses the major functions of any system or organization—planning, organizing/implementation, and management.
Torque ripple minimization of switched reluctance motors based on fuzzy logic and sliding mode control (2013)

The torque ripple reduction control of the switched reluctance motor (SRM) is generally implemented by current control, turn-on and turn-off control based on the inductance profile. Turn-off angle control, as a complex relation between motor speed and current, is required for a wide range of operating speeds. However, these methods show limited performance. This paper presents a fuzzy logic turn-off angle control scheme with a sliding mode torque control considering complex and nonlinear characteristics of SRM. Since a turn-off angle controller cannot reduce torque ripple satisfactorily in commutation region, this paper additionally applies a sliding mode torque controller. The proposed control strategy combines fuzzy logic turn-off angle control and sliding mode torque control which does not require a complex look-up table and allows a wide speed range operation. Simulation results are presented to verify the effectiveness of the proposed torque ripple minimization technique.
Narrow spectral linewidth under wavelength tuning in thermally tunable super-structure-grating (SSG) DBR lasers (1995)

Narrow spectral linewidth characteristics are demonstrated in thermally wavelength tunable super-structure-grating distributed Bragg reflector (SSG-DBR) InGaAsP-InP lasers. SSG reflectors were fabricated with a multiple-phase-shift insertion method using electron-beam lithography. The phase distributions of the SSG's were optimized to obtain uniform reflection peaks. Incorporating thin-film Pt heaters into the lasers enables us to tune the lasing wavelength by the thermal effect. The device has a wide quasi-continuous tuning range of 40 nm with CW operation at room temperature. The spectral linewidths, frequency fluctuations, and tuning speed in thermal wavelength tuning were studied compared with those in electrical tuning. Experimental results showed that thermal tuning does not influence frequency fluctuations and spectral linewidths, but the tuning speed was slow. Narrow spectral linewidths below 400 kHz were achieved in a wide quasi-continuous tuning range of 40 mm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An NMDA Intervention Strategy in Schizophrenia With “Low-Dose” Milacemide (1991)

Drugs (e.g., PCP) which interfere with glutamatergic transmission at the N-methyl D-aspartate (NMDA) subclass of glutamate receptors precipitate both positive and negative symptoms of psychosis in humans. Based on a proposed "glutamatergic deficiency" in schizophrenia, pharmacologic facilitation of NMDA-mediated neural transmission by direct stimulation of the strychine-insensitive glycine binding site was attempted with "low-dose" milacemide, an acylated "prodrug" of glycine that readily crosses the blood brain barrier and is converted into glycine in the brain. In a prior study, "high-dose" milacemide proved to have no therapeutic utility in schizophrenia. The failure was thought, possibly, to be related to higher doses of milacemide having antagonist actions at the NMDA receptor complex. In the current study, "low-dose" milacemide (400 mg/day), as the sole pharmacotherapeutic agent, was also without significant clinical benefit. Despite our negative findings for milacemide, other strategies for facilitating NMDA-mediated neural transmission in schizophrenia might be worth pursuing.
Dielectric Characteristics of Pb(Sc 1/2-x Ta 1/2+x )O 3+x Ceramic System (1995)

PST-series specimens with stoichiometric and nonstoichiometric compositions were prepared and the effects of composition modification on phase formation and dielectric response were investigated. The phases formed on calcination were mainly perovskite and trace amount of pyrochlore(s), with an increase of the latter phase(s) as the composition became more nonstoichiometric. The sintered samples showed thermal hysteresis and diffuseness in phase transition with a small degree of frequency relaxation. Temperatures corresponding to maximum values of dielectric constant and loss were relatively insensitive to the composition change while the maximum values were very sensitive to that.
Toward Personalized Therapy for Smoking Cessation: A Randomized Placebo-controlled Trial of Bupropion (2008)

We examined whether a pretreatment phenotypic marker of nicotine metabolism rate (NMR) predicts successful smoking cessation with bupropion. Smokers (N = 414) were tested for pretreatment NMR, based on the ratio of 3′-hydroxycotinine/cotinine derived during smoking, before entering a placebo-controlled randomized trial of bupropion plus counseling. At the end of the 10-week treatment phase, slow metabolizers (1st NMR quartile) had equivalent quit rates with placebo or bupropion (32%). Fast metabolizers (4th NMR quartile) had low quit rates with placebo (10%), and these were enhanced significantly by bupropion (34%). Smokers in the 2nd quartile (placebo: 25%, bupropion: 30%) and the 3rd quartile (placebo: 20%, bupropion: 30%) did not benefit significantly from bupropion. At the 6-month follow-up, the relationship between the NMR and quitting remained similar, but was no longer statistically significant. A pretreatment assessment of NMR may identify smokers who are most and least likely to benefit from treatment with bupropion for smoking cessation. Clinical Pharmacology & Therapeutics (2008); 84, 3, 320–325 doi:10.1038/clpt.2008.57
A Geographical Observation System based on P2P Agents (2008)

In this paper, a novel design and implementation of a geographical observation system based on P2P agents is described. We propose sensor agent architecture to realize efficient and real-time notifications of sensor information. In this architecture, sensors act as agents and send updated notification messages to the observer agents which satisfy specified conditions by making use of multiple overlays. These features are implemented on P2P agent software 'PIAX'. In this implementation, Web browsers and cellular phones can act as observer agents.
Transport theory revisited - 1960–1995 (A case history) (1997)

Abstract This is the written version of an invited presentation at the Fourteenth International Conference on Transport Theory held in Beijing, China, June 12–17, 1995.
Analysis of DNS Cache Effects on Query Distribution (2013)

This paper studies the DNS cache effects that occur on query distribution at the CN top-level domain (TLD) server. We first filter out the malformed DNS queries to purify the log data pollution according to six categories. A model for DNS resolution, more specifically DNS caching, is presented. We demonstrate the presence and magnitude of DNS cache effects and the cache sharing effects on the request distribution through analytic model and simulation. CN TLD log data results are provided and analyzed based on the cache model. The approximate TTL distribution for domain name is inferred quantificationally.
Diminished Autophagy Limits Cardiac Injury in Mouse Models of Type 1 Diabetes (2013)

Cardiac autophagy is inhibited in type 1 diabetes. However, it remains unknown if the reduced autophagy contributes to the pathogenesis of diabetic cardiomyopathy. We addressed this question using mouse models with gain- and loss-of-autophagy. Autophagic flux was inhibited in diabetic hearts when measured at multiple time points after diabetes induction by streptozotocin as assessed by protein levels of microtubule-associated protein light chain 3 form 2 (LC3-II) or GFP-LC3 puncta in the absence and presence of the lysosome inhibitor bafilomycin A1. Autophagy in diabetic hearts was further reduced in beclin 1- or Atg16-deficient mice but was restored partially or completely by overexpression of beclin 1 to different levels. Surprisingly, diabetes-induced cardiac damage was substantially attenuated in beclin 1- and Atg16-deficient mice as shown by improved cardiac function as well as reduced levels of oxidative stress, interstitial fibrosis, and myocyte apoptosis. In contrast, diabetic cardiac damage was dose-dependently exacerbated by beclin 1 overexpression. The cardioprotective effects of autophagy deficiency were reproduced in OVE26 diabetic mice. These effects were associated with partially restored mitophagy and increased expression and mitochondrial localization of Rab9, an essential regulator of a non-canonical alternative autophagic pathway. Together, these findings demonstrate that the diminished autophagy is an adaptive response that limits cardiac dysfunction in type 1 diabetes, presumably through up-regulation of alternative autophagy and mitophagy.