gebhart/patrepeval huggingface dataset:
Operation of Membrane Bioreactor with Powdered Activated Carbon Addition (2006)

Abstract The effect of powdered activated carbon (PAC) addition to the activated sludge (AS) in a membrane bioreactor (MBR) has been investigated. The long term nature of the tests allowed the PAC to gradually incorporate into the biofloc forming biologically activated carbon (BAC). One series of tests involved 4 bench scale (2 L) MBRs operated at sludge retention times (SRTs) of 30 days with PAC inventories of 0, 1, 3 and 5 g/L and steady state biomass concentrations of 12.0±1.0 g/L. The characteristics of the mixed liquors (MLSS) from the 4 reactors were compared. Short term filtration tests, including measurement of specific cake resistance (SCR), flux decline profile, and irreversible fouling resistance in an unstirred cell and “sustainable” flux (by monitoring transmembrane pressure (TMP) rise) in a crossflow cell all showed better filtration performance for the MLSS with BAC compared with the AS alone. In terms of SCR and flux decline profile the 1 g/L PAC addition performed best, but in terms of minimizing irreversible membrane fouling and maximizing “sustainable” flux the 5 g/L PAC was best. All 4 systems showed lower total organic carbon (TOC) in the permeate compared to the bioreactors, but the lowest permeate TOC (and the best removal) was for the highest PAC loading. The benefit of PAC addition was confirmed in a second series of tests with two 20 L MBRs with submerged hollow fibers, one operated without PAC, the MBR(AS), and the other with 5 g/L PAC, the MBR(BAC). For an SRT of 30 days (which involved 3.3% sludge wastage per day and 3.3% new PAC addition per day) and a fixed flux of 21 L/m2hr the MBR(AS) showed a TMP rise of about 2.4 kPa/day whereas the MBR(BAC) showed a rise of only 0.8 kPa/day. However when the MBRs were operated without wastage the performance of the MBR(BAC) was worse than the MBR(AS). Thus the improved performance of the MBR(BAC) requires regular replenishment of aged BAC with fresh PAC.
Planar <i>p</i>-on-<i>n</i> HgCdTe heterostructure photovoltaic detectors (1993)

We report a process to fabricate planar Hg1−yCdyTe/Hg1−xCdxTe (x&lt;y) heterostructure photodiodes with the p-on-n configuration. The material used for this demonstration was grown by molecular beam epitaxy. The p-on-n planar devices consist of an arsenic-doped p-type epilayer (y=0.28) on top of a long wavelength infrared n-type epilayer (x=0.225, λ=10 μm). The planar junctions were formed by selective pocket diffusion of arsenic deposited by ion implantation. The detailed analysis of the current-voltage characteristics of these diodes as a function of temperature show that they have high performance and that their dark currents are diffusion limited down to 52 K. The results also show that the R0A values for these devices are highly uniform at 77 K.
The association of the sebum excretion rate with melasma, erythematotelangiectatic rosacea, and rhytides (2015)

Continuing research with facial modeling and measurement systems will allow for development of more objective facial assessments. Future studies need to assess the role of technology in stratifying the severity and subtypes of rosacea and melasma. Furthermore, the role of sebaceous regulation may have important implications in photoaging.
In Silico Analysis of Gene Function and Transcriptional Regulators Associated with Endoplasmic Recticulum (ER) Stress (2009)

ER stress에 관련된 유전자의 기능변화와 전사조절인자 분석하기 위해 ER stress를 유도한 간세포에서 expression microarray로 유전자 발현을 확보한 후 GSECA로 분석하였다. ER stress가 유도되면, ER에 주어지는 과도한 부하를 감소시키는 기능들이 증가하는 반면, ER stress가 더 증가함에 따라 ATP 생성이나 DNA repair, 더 나아가 세포분열의 기능이 감소하는 등 세포가 damage을 받음을 알 수 있었다. ER stress에 관련된 전사조절인자로는 FOX04, AP-1, FOX03, HNF4, IRF-1, GATA 등의 전사조절인자들이 ER stress에 의해 발현이 증가하는 유전자들의 promoter에 공통적으로 존재하였으며, E2F, Nrf-1, Elk-1, YY1, CREB, MTF-1, STAT-1, ATF 등의 전사인자들이 발현이 감소하는 유전자들의 promoter에서 공통적으로 존재하여, 이들의 전사인자들이 ER stress에 의한 유전자의 발현조절에 중요한 역할을 하는 전사조절인자임을 알 수 있었다. It has been postulated that endoplasmic (ER) stress is involved in the development of several diseases. However, the detailed molecular mechanisms have not been fully understood. Therefore, we characterized a genetic network of genes induced by ER stress using cDNA microarray and gene set expression coherence analysis (GSECA), and identified gene function as well as several transcription regulators associated with ER stress. We analyzed time-dependent gene expression profiles in thapsigargin-treated Sk-Hep1 using an oligonucleotide expression chip, and then selected functional gene sets with significantly high expression coherence which was processed into functional clusters according to the expression similarities. The functions related to sugar binding, lysosome, ribosomal protein, ER lumen, and ER to golgi transport increased, whereas the functions with mRNA processing, DNA replication, DNA repair, cell cycle, electron transport chain and helicase activity decreased. Furthermore, functional clusters were investigated for the enrichment of regulatory motifs using GSECA, and several transcriptional regulators associated with regulation of ER-induced gene expression were found.
Reduction Des Groupes Fonctionnels Nitroaromatiques Par L'Hydrogene en Presence de Palladium Sur Charbon (1974)

Abstract En utilisant la méthode de réduction habituelle ďhydrogénation catalysée par le palladium sur charbon sur des composés nitroaromatiques, nous nous sommes aperçus que la vitesse ďabsorption ďhydrogène décroissait en fonction du temps et que ces réactions n'étaient qu'exceptionnelement complètes. Certains auteurs1 signalent que cette réaction est plus rapide et plus sélective en milieu neutre qu'en milieu acide ou basique.
Determination of film thickness and refractive index in one measurement of phase-modulated ellipsometry (2006)

Ellipsometry is often used to determine the refractive index and/or the thickness of a polymer layer on a substrate. However, simultaneous determination of these parameters from a single-wavelength single-angle measurement is not always possible. The present study determines the sensitivity of the method to errors of measurement for the case of phase modulated ellipsometry and identifies conditions for decoupling film thickness and refractive index. For a specific range of film thickness, both the thickness and the refractive index can be determined from a single measurement with high precision. This optimal range of the film thickness is determined for organic thin films, and the analysis is tested on hydrogel-like polymer films in air and in water.
Persistency semantics of the Intel-x86 architecture (2019)

Emerging non-volatile memory (NVM) technologies promise the durability of disks with the performance of RAM. To describe the persistency guarantees of NVM, several memory persistency models have been proposed in the literature. However, the persistency semantics of the ubiquitous x86 architecture remains unexplored to date. To close this gap, we develop the Px86 (‘persistent x86’) model, formalising the persistency semantics of Intel-x86 for the first time. We formulate Px86 both operationally and declaratively, and prove that the two characterisations are equivalent. To demonstrate the application of Px86, we develop two persistent libraries over Px86: a persistent transactional library, and a persistent variant of the Michael–Scott queue. Finally, we encode our declarative Px86 model in Alloy and use it to generate persistency litmus tests automatically.
Influence of fuel sulfur on the composition of aircraft exhaust plumes: The experiments SULFUR 1–7 (2002)

The series of SULFUR experiments was performed to determine the aerosol particle and contrail formation properties of aircraft exhaust plumes for different fuel sulfur contents (FSC, from 2 to 5500 μg/g), flight conditions, and aircraft (ATTAS, A310, A340, B707, B747, B737, DC8, DC10). This paper describes the experiments and summarizes the results obtained, including new results from SULFUR 7. The conversion fraction ε of fuel sulfur to sulfuric acid is measured in the range 0.34 to 4.5% for an older (Mk501) and 3.3 ± 1.8% for a modern engine (CFM56‐3B1). For low FSC, ε is considerably smaller than what is implied by the volume of volatile particles in the exhaust. For FSC ≥ 100 μg/g and ε as measured, sulfuric acid is the most important precursor of volatile aerosols formed in aircraft exhaust plumes of modern engines. The aerosol measured in the plumes of various aircraft and models suggests ε to vary between 0.5 and 10% depending on the engine and its state of operation. The number of particles emitted from various subsonic aircraft engines or formed in the exhaust plume per unit mass of burned fuel varies from 2 × 10 14 to 3 × 10 15 kg −1 for nonvolatile particles (mainly black carbon or soot) and is of order 2 × 10 17 kg −1 for volatile particles >1.5 nm at plume ages of a few seconds. Chemiions (CIs) formed in kerosene combustion are found to be quite abundant and massive. CIs contain sulfur‐bearing molecules and organic matter. The concentration of CIs at engine exit is nearly 10 9 cm −3 . Positive and negative CIs are found with masses partially exceeding 8500 atomic mass units. The measured number of volatile particles cannot be explained with binary homogeneous nucleation theory but is strongly related to the number of CIs. The number of ice particles in young contrails is close to the number of soot particles at low FSC and increases with increasing FSC. Changes in soot particles and FSC have little impact on the threshold temperature for contrail formation (less than 0.4 K).
ENF based location classification of sensor recordings (2013)

The Electric Network Frequency (ENF) signal can be captured in multimedia signals recorded in areas of electrical activity. This has led to the emergence of many forensic applications based on the use of ENF signals such as validating the time-of-recording of an ENF-containing multimedia signal or estimating its recording location based on concurrent reference signals from power grids. In this paper, we examine a novel application based on the use of the ENF signal that seeks to estimate the power grid in which an ENF-containing multimedia signal was recorded without relying on the availability of concurrent power references. We derive features based on the statistical differences in ENF variations between different grids to serve as signatures for the grid-of-recording of an ENF-containing signal. We use these features in a multiclass machine learning system that is able to identify the grid-of-recording of a signal with a high accuracy.
Crystallization and Properties of a Low k Glass Composite (1995)

The effect of gallium oxide on crystallization, thermal expansion and dielectric behaviors of a binary glass composite which contains a low-softening Pyrex borosilicate glass and a high-softening high silica glass has been studied. It is found that on sintering, cristobalite precipitates out of the initial amorphous binary glass mixture; however, the addition of gallium oxide prevents this. The above result is further supported by microstructural observation, thermal expansion and dielectric constant measurements.
2D simultaneous spatial and temporal focusing as a fast-scanning two-photon excited fluorescence microscopy (2013)

We propose a two-dimensional simultaneous spatial and temporal focusing (SSTF) microcopy employing a VIPA and a grating, which can improve both axial resolution and background noise compared to 1-D SSTF microscopy.
SIMPSON'S PARADOX AND CORNFIELD'S CONDITIONS (1999)

Simpson's Paradox occurs when an observed association is spurious – reversed after taking into account a confounding factor. At best, Simpson's Paradox is used to argue that association is not causation. At worst, Simpson's Paradox is used to argue that induction is impossible in observational studies (that all arguments from association to causation are equally suspect) since any association could possibly be reversed by some yet unknown confounding factor. This paper reviews Cornfield's conditions – the necessary conditions for Simpson's Paradox – and argues that a simple -difference form of these conditions can be used to establish a minimum effect size for any potential confounder. Cornfield's minimum effect size is asserted to be a key element in statistical literacy. In order to teach this important concept, a graphical technique was developed to illustrate percentage-point difference comparisons. Some preliminary results of teaching these ideas in an introductory statistics course are presented.
Tetracycline administration normalizes the structure and acid phosphatase activity of osteoclasts in streptozotocin‐induced diabetic rats (1990)

Diabetes induces osteopenia, which is characterized by a deficiency of osteoid and decreased activity of osteoblasts. We recently found that tetracyclines prevent the loss of osteoid and bone matrix and the degeneration of osteoblasts in diabetic rats by a mechanism independent of their antimicrobial efficacy. However, bone remodeling requires the activity of osteoclasts as well as osteoblasts. To determine the in vivo effects of tetracycline on osteoclasts in long bones, either a tetracycline (minocycline, TC) or its chemically modified non-antibiotic analogue (CMT), 4-de-dimethylaminotetracycline, was administrated daily to streptozotocin-induced diabetic rats by oral intubation. After 21 days, the rats were perfusion-fixed with a mixture of formaldehyde and glutaraldehyde, and the humeri were dissected and processed for ultracytochemical demonstration of acid trimetaphosphatase (ACPase) activity. In untreated non-diabetic (control) rats, the osteoclasts at the zone of provisional ossification exhibited abundant mitochondria and cisterns of rough endoplasmic reticulum (RER) throughout the cytoplasm, prominent stacks of Golgi membranes, and lysosomes in the perinuclear cytoplasm, and numerous various pale vacuoles in the cytoplasmic area adjacent to well-developed ruffled border. Intense ACPase activity was observed in the Golgi saccules, lysosomes, pale vacuoles, and the extracellular canals of ruffled border. The reaction products were also noted along the resorbing bone surfaces associated with the osteoclast ruffled border. The osteoclasts in the untreated diabetic rats showed a cytoplasmic organization similar to that of the non-diabetic control rats, but showed little or no ruffled border which was replaced by a broad clear zone in some of these cells. However, most of the osteoclasts on bone matrix in the diabetics were devoid of both a ruffled border and a clear zone. ACPase activity was detected in the osteoclast cytoplasm of diabetic rat, as in the controls, but to a much lesser extent along the broad clear zone facing the resorbing bone surfaces. The osteoclasts in TC-treated diabetic rats possessed both a clear zone and a small ruffled border. However, in some cases, they lacked both structures reminiscent of the untreated diabetic cells. The osteoclasts of CMT-treated diabetic rats exhibited structural and enzymatic features essentially identical to those of the non-diabetic control rats. These results suggest that the diabetes-induced osteopenia results, at least in part, from degeneration of osteoclasts (as well as atrophic osteoblasts) and that tetracyclines may be effective in preventing these abnormalities by a mechanism not dependent on the drugs' antimicrobial properties.
Nonlinear single wavelength polarization switching in InGaAs/InP quantum well waveguides (1995)

The existence of two polarization dependent band edges in InGaAs/InP quantum well material has been used to demonstrate single wavelength all-optical switching in a nonlinear guided wave Fabry–Perot resonator. The device had a single quantum well embedded in the optical waveguide and was characterized as a function of input pump power and laser wavelength using laser pulses of about 45 ps duration at a repetition rate of 82 MHz. A signal gain factor of over two was obtained for pump pulses of 1.2 pJ and the optimum operating wavelength of 1.51 μm was found to coincide with the heavy hole exciton absorption resonance.
Surgical treatment of distant metastatic melanoma indications and results (1985)

A retrospective study was made of the surgical treatment of distant metastases from melanoma in 143 patients. The determinants of survival benefit were: (1) successful complete resection of all clinical disease; (2) single versus multiple metastatic site; and (3) anatomic location of disease. Complete resection was achieved with single- and multiple-site lesions in 67% and 31% of the patients, respectively, yielding corresponding 5-year survival rates of 33% and 9%, respectively. Incomplete resection yielded little survival benefit. Soft tissue and extraregional nodal lesions were completely resectable in 70%, whereas pulmonary, extrahepatic abdominal visceral, and osseous lesions were in 40% of the patients, resulting in similar 5-year survival rates of 17% to 22%. The operative mortality rate was 1.4% (2/143). Unsuccessful resection frequently led to very long hospitalization periods for complications and disease, with some patients spending more than 50% of their remaining survival time in the hospital. These observations suggest that, with proper selection of patients, guided by these determinants, surgical resection can offer a reasonable expectation of prolonged survival.
Pre-early functions of bacteriophage T5 and its relatives (2015)

SummaryColiphage T5 injects its DNA in 2 steps: the first step transfer (FST) region 7.9% is injected and its genes are expressed and only then does the remainder (second step transfer, SST) of its DNA enter the cell. In the FST region, only 2 essential genes (A1 and A2) have been identified and a third (dmp) non-essential gene codes for a deoxyribonucleotide 5′ monophosphatase. Thirteen additional putative ORFs are present in the FST region. Numerous properties have been attributed to FST region, including SST, host DNA degradation, inhibition of host RNA and protein synthesis, restriction insensitivity and protection of T5 DNA. These effects do not occur following infection with an A1 mutant. The A2 gene seems only to be involved in SST transfer. This is puzzling since there are more seemingly unrelated effects than there are essential genes to accomplish them and it is possible that some important genes were not identified. This review attempts to analyze these problems that were first identified in the 1970–80 s. In particular, an attempt is made to determine which potential ORFs are conserved in evolution (and thus likely to be important); by comparing T5 to 10 newly isolated and completely sequenced T5-like phages. A similar approach is used to identify conserved repeats, inverted repeats and palindromes that occur in all T5-like phages in the region containing the injection stop signal (iss) and the terminase substrate. Finally, an attempt is made to re-analyze the mechanism whereby T5 protects itself from the enzymes that degrade host DNA, from the RecBCD nuclease and from restriction enzymes. For all of these FST effects new hypotheses and possible new genetic and biochemical approaches are envisaged.
Diastereoselectivity and asymmetric induction in the Diels–Alder reaction of <i>o</i>-quinodimethanes (1986)

The extent of asymmetric induction in the bimolecular Diels–Alder reactions of chiral o-quinodimethanes with dimethyl fumarate, methyl acrylate, and maleic anhydride has been studied. o-Quinodimethanes with chiral α-alkoxy groups were prepared from 1-alkoxy-1,3-dihydrobenzo[c]thiophene-2,2-dioxides 4a–f or 1-alkoxy-3-phenyl-1,3-dihydrobenzo[c]thiophene-2,2-dioxides 4g–h by thermolysis. These alkoxybenzosulfones were prepared from the corresponding hydroxybenzosulfones 8 and 1-phenylethanol, 2-phenyl-1-propanol, 4-phenyl-2-butanol, 1-phenyl-2-propanol, 3,3-dimethyl-2-butanol, or 1-cyclo-hexylethanol. The 1-phenylethoxy substituent yielded the largest asymmetric induction. The absolute configurations of the major cycloadducts of methyl acrylate with the o-quinodimethanes generated from 1-(R- 1-phenylethoxy)- and 1-(S-1-phenylethoxy)-1,3-dihydrobenzo[c]thiophene-2,2-dioxides 4i and 4j have been determined to be 1S,2S-1-(R-1-phenylethoxy)- and 1R,2R-1-(S-1-phenylethoxy)-2-carbomethoxy-1,2,3,4-tetrahydronaphthalene 11i and 11j, respectively. The proposition that a chiral alkoxy substituent can block one face of the o-quinodimethane towards addition of a dienophile is discussed.
Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. (1989)

Defensins are small, cysteine-rich antimicrobial peptides that are abundant in human, rabbit, and guinea pig neutrophils (PMN). Three defensins (human neutrophil peptide defensin [HNP]-1, HNP-2, and HNP-3) constitute between 30 and 50% of the total protein in azurophil granules of human PMN. We examined the mechanism of HNP-mediated bactericidal activity against Escherichia coli ML-35 (i-, y-, z+) and its pBR322-transformed derivative, E. coli ML-35p. Under conditions that supported bactericidal activity, HNP-1 sequentially permeabilized the outer membrane (OM) and inner membrane (IM) of E. coli. Coincident with these events, bacterial synthesis of DNA, RNA, and protein ceased and the colony count fell. Although these events were closely coupled under standard assay conditions, OM permeabilization was partially dissociated from IM permeabilization when experiments were performed with E. coli that had been plasmolyzed by mannitol. Under such conditions, the rate and extent of bacterial death more closely paralled loss of IM integrity than OM permeabilization. Electron microscopy of E. coli that had been killed by defensins revealed the presence of striking electron-dense deposits in the periplasmic space and affixed to the OM. Overall, these studies show that HNP-mediated bactericidal activity against E. coli ML-35 is associated with sequential permeabilization of the OM and IM, and that inner membrane permeabilization appears to be the lethal event.
M-DNA/Transition Metal Dichalcogenide Hybrid Structure-based Bio-FET sensor with Ultra-high Sensitivity (2016)

Here, we report a high performance biosensor based on (i) a Cu<sup>2+</sup>-DNA/MoS<sub>2</sub> hybrid structure and (ii) a field effect transistor, which we refer to as a bio-FET, presenting a high sensitivity of 1.7 × 10<sup>3</sup> A/A. This high sensitivity was achieved by using a DNA nanostructure with copper ions (Cu<sup>2+</sup>) that induced a positive polarity in the DNA (receptor). This strategy improved the detecting ability for doxorubicin-like molecules (target) that have a negative polarity. Very short distance between the biomolecules and the sensor surface was obtained without using a dielectric layer, contributing to the high sensitivity. We first investigated the effect of doxorubicin on DNA/MoS<sub>2</sub> and Cu<sup>2+</sup>-DNA/MoS<sub>2</sub> nanostructures using Raman spectroscopy and Kelvin force probe microscopy. Then, we analyzed the sensing mechanism and performance in DNA/MoS<sub>2</sub>- and Cu<sup>2+</sup>-DNA/MoS<sub>2</sub>-based bio-FETs by electrical measurements (I<sub>D</sub>-V<sub>G</sub> at various V<sub>D</sub>) for various concentrations of doxorubicin. Finally, successful operation of the Cu<sup>2+</sup>-DNA/MoS<sub>2</sub> bio-FET was demonstrated for six cycles (each cycle consisted of four steps: 2 preparation steps, a sensing step, and an erasing step) with different doxorubicin concentrations. The bio-FET showed excellent reusability, which has not been achieved previously in 2D biosensors.