gebhart/patrepeval huggingface dataset:
Epilepsy and Brain Tumors: Implications for Treatment (1990)

Primary intraparenchymal tumors of the brain are important etiologic factors in partial or focal epilepsy. Indolent low-grade gliomas may be associated with a long-standing seizure disorder refractory to medical treatment. Surgical resection of the neoplasm and the epileptogenic area may render patients seizure-free. Removal of the tumor alone may also be associated with an excellent survival rate and surgical outcome. Conventional neurosurgical procedures are restricted in patients with tumors that are deep-seated lesions or involve functional cerebral cortex. Computer-assisted stereotactic surgical procedures have been developed for biopsy and resection of intra-axial brain-mass lesions. Stereotactic tumor resection may allow pathological determination of intracranial lesions and produce a worthwhile reduction in seizure activity in some patients with intractable partial epilepsy.
<title>Adaptive signal estimation using projection libraries</title> (1997)

Many results in approximation theory, nonparametric regression, and adaptive signal representation assume that the signal is a smooth function or nonstationary in some smooth sense. These assumptions are not always applicable and perhaps even more importantly the times where the signal is not smooth are themselves important features to preserve in the signal representation. Previously, computationally efficient methods were developed to implement these approaches for the relatively simple problem of estimating multiple change points from a piecewise constant signal. In this paper, this approach is presented in the modern framework of waveform dictionaries, bases libraries, and atomic decomposition.
Performance of efficient balanced codes (1991)

The problem of appraising the spectral performance of codes based on a new algorithm for generating zero-disparity codewords presented by D.E. Knuth (1986) is addressed. In order to get some insight into the efficiency of Knuth's construction technique, the authors evaluate the spectral properties of its code streams. The structure of Knuth codes allows the derivation a simple expression for (an approximation to) the sum of variance of these codes. This quantity plays a key role in the spectral performance characterization of DC-balanced codes. The authors evaluate this expression and compare the sum variance of Knuth codes with the sum variance of the polarity bit codes for fixed redundancy. Under the premise that the sum variance can serve as a quantity to judge the width of the spectral notch, the authors conclude that codes based on Knuth's algorithm offer less spectral suppression than polarity bit codes with the same redundancy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A New Method for RTS Noise of Semiconductor Devices Identification (2008)

In this paper, a new method, called the noise scattering pattern method (NSP method), for random telegraph signal noise identification in the inherent noise of semiconductor devices is described. A block diagram of a noise measurement system based on the NSP method is presented. Examples of patterns of the NSP method are included.
Large-scale production of lentiviral vector in a closed system hollow fiber bioreactor (2015)

Lentiviral vectors are widely used in the field of gene therapy as an effective method for permanent gene delivery. While current methods of producing small scale vector batches for research purposes depend largely on culture flasks, the emergence and popularity of lentiviral vectors in translational, preclinical and clinical research has demanded their production on a much larger scale, a task that can be difficult to manage with the numbers of producer cell culture flasks required for large volumes of vector. To generate a large scale, partially closed system method for the manufacturing of clinical grade lentiviral vector suitable for the generation of induced pluripotent stem cells (iPSCs), we developed a method employing a hollow fiber bioreactor traditionally used for cell expansion. We have demonstrated the growth, transfection, and vector-producing capability of 293T producer cells in this system. Vector particle RNA titers after subsequent vector concentration yielded values comparable to lentiviral iPSC induction vector batches produced using traditional culture methods in 225 cm(2) flasks (T225s) and in 10-layer cell factories (CF10s), while yielding a volume nearly 145 times larger than the yield from a T225 flask and nearly three times larger than the yield from a CF10. Employing a closed system hollow fiber bioreactor for vector production offers the possibility of manufacturing large quantities of gene therapy vector while minimizing reagent usage, equipment footprint, and open system manipulation.
Removal of cadmium and cyanide from aqueous solutions through electrodialysis (2003)

The discharge of galvanic industry wastewaters containing heavy metals and cyanide is one of the largest sources of water pollution. The use of the electrodialysis technique for the treatment of a synthetic wastewater containing approximately 0.0089 mol L-1 cadmium and 0.081 mol L-1 cyanide was studied using a five-compartment electrodialysis cell. The results demonstrate that the removal of cadmium and cyanide depends on the applied current density and it is limited by the precipitation of cadmium on the cation-exchange membrane in the diluate central cell compartment.
An automatic method for motion artifacts detection in photoplethysmographic signals referenced with electrocardiography data (2014)

This work presents an automatic motion artifact detection algorithm for photoplethysmographic (PPG) signals with synchronized electrocardiography (ECG) data. 18 features from time and frequency domain were extracted and used in a support vector machine (SVM) for automatic classification. The performance achieved by this method (SE: 87.5%, SP: 85.5% and CR: 86.8%) proves that the information extracted from the relationship between electrocardiography and PPG can be used to identify segments of motion artifacts in PPG signals.
Contributions to the Optimal Use of Human Blood (1976)

The influence of different variables on the yield of factor VIII in cryoprecipitate as prepared in the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, was studied. The following conclusions may be drawn: (1) In case blood should be stored, the use of the anticoagulant solution acid citrate dextrose (ACD) is preferable to citrate phosphate dextrose (CPD) or trisodium citrate (TSC). (2) The temperature of stored whole blood should not decrease below 8 °C because of a spontaneous precipitation of factor VIII from blood (and plasma) below this temperature. (3) Cryoprecipitate derived from rapidly frozen plasma (1 min) contains a decreased amount of proteins in comparison with cryoprecipitate prepared from slowly frozen plasma (45 min to 4 h). On the other hand, equal amounts of factor VIII activity were obtained in the precipitate after freezing of plasma at varying rates. (4) Rapid thawing of plasma results in both higher yields of factor VIII procoagulant activity and a higher specific activity of this factor in the resulting cryoprecipitate. (5) The sedimentation of cryoprecipitate is completed after 5 min centrifugation at 1,500 g. (6) At temperatures higher than 8 °C, cryoprecipitated factor VIII starts dissolving into the supernatant plasma or in buffer. (7) Factor VIII in lyophilized cryoprecipitate is stable at room temperature. At elevated temperatures it rapidly looses its activity. (8) Evidence was obtained that the improvements which are introduced in the preparation of factor VIII do not lead to a product which is less stable in vitro as well as in vivo.
Raman Scattering Studies of Electrically Active Impurities in in Situ B-Doped Silicon Nanowires: Effects of Annealing and Oxidation (2007)

The concentration of electrically active impurities in in situ boron (B)-doped silicon (Si) nanowires (SiNWs) synthesized by gold (Au)-catalyzed chemical vapor deposition (CVD) is studied by Raman spectroscopy. B-doped SiNWs exhibit an asymmetric Raman spectrum due to Fano resonance between discrete phonon Raman scattering and continuous electric Raman scattering caused by the excitation of holes in the valence band. To quantitatively evaluate the concentration of active B atoms from the asymmetric spectral shape, the spectra are fitted by a Fano resonance formula and asymmetry parameters are extracted. From the comparison of the asymmetry parameter with those obtained for reference samples, the concentration of active B atoms in SiNWs is estimated. The effects of thermal annealing in nitrogen and oxygen gases on the active B concentration are also studied. The annealing in nitrogen ambience for a short period significantly increases the concentration of active B atoms especially when the doping level is high, while longer period annealing decreases the active B concentration. The reduction of active B concentration is more significant when SiNWs are annealed in oxygen gas ambience. By combining Raman results with high-resolution transmission electron microscope observations, the growth mechanism of B-doped SiNWs is discussed. We show that the number of B atoms doped into SiNWs via Au catalysts is very limited and high B concentration layers are grown by conformal growth on the sidewall of SiNWs.
Toxic Effects of Soybean Saponin and Its Calcium Salt on the Rice Weevil1 (1972)

Soybean saponin and its calcium salt showed high toxicity to Sitophilus oryzae (L.). Saponin, an active component of soybeans, gave a high degree of protection to wheat that was dusted at 300 ppm. Dosages of 600 to 5000 ppm showed increases in effectiveness. A dosage of 600 ppm produced 100% mortality within 1 week. A dosage of 150 ppm was less effective hut still toxic to the insects. The calcium salt was slightly less toxic to the insects than was the saponin. Soybean meal and defatted soybeans also gave protection to wheat when dusted at the higher dosage levels tested.
Open spaces and molecular motions in carbon‐black‐ and silica‐loaded SBR investigated using positron annihilation (2001)

Abstract Lifetime spectra of positrons were measured for styrene–butadiene rubber (SBR) vulcanizates filled with carbon black (CB) or silica. At temperatures between 10 and 420 K, no large difference between the size of the open spaces in the CB/SBR vulcanizate and that in the specimen without the filler was observed. Above the glass‐transition temperature ( T g = 230 K), the same was true for the silica/SBR vulcanizate. Below T g , however, the size of the open spaces was reduced by the incorporation of silica as a result of the suppression of local molecular motions in the SBR. The density of the open spaces was reduced by the incorporation of the fillers. However, above 400 K it started to increase in the silica/SBR vulcanizate. For the CB/SBR vulcanizate, the introduction of open spaces was well suppressed, even at 420 K. © 2001 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 39: 835–842, 2001
Peptides adsorbed on reverse‐phase chromatographic beads as targets for femtomole sequencing by post‐source decay matrix assisted laser desorption ionization‐reflectron time of flight mass spectrometry (MALDI‐RETOF‐MS) (1997)

We here describe a procedure for concentrating peptides from solutions by adsorbing them onto reverse-phase beads that were added to these solutions. The beads are then transferred to the target disc of the matrix assisted laser desorption ionization-reflectron time of flight (MALDI-RETOF) mass spectrometer. Because of their hydrophobic nature, these beads cluster in a very small area on the target disc assuring an important concentration step. After drying, peptides are desorbed from the beads by adding a small volume of 50% acetonitrile in 0.1% trifluroacetic acid in water containing the matrix components. Hereby we focus the original amount of peptide material on the target disc on a very small surface, producing highly concentrated peptide-matrix mixtures. This permits high yield identification and sequence tagging by post-source-decay analysis on peptides derived from proteins only available in the femtomole range from one-dimensional (1-D) or two-dimensional (2-D) gels. The procedure is illustrated by the identification of 38 proteins from human thrombocyte membrane skeletons.
Tunnel FET with non-uniform gate capacitance for improved device and circuit level performance (2012)

We propose and report the significant improvement obtained by a non-uniform gate capacitance made by appropriate combination of high-k and low-k regions over the tunneling and the channel regions of a heterostucture TFET (called HKLKTFET). In addition to significantly enhanced I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> and subthreshold swing, we find that this structure offers great improvements for the dynamic switching energy (66% saving) and propagation delay (~3X fast operation) compared to a heterostructure TFET (HeTFET) due to the reduction of the Miller effect. We compare and benchmark the proposed device against a 65nm low stand-by power (LSP) CMOS technology, and we show that at a supply voltage of V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> = 0.4V , TFETs can have smaller propagation delays compared to CMOS operating in the subthreshold region.
Drawing Sensors with Ball-Milled Blends of Metal-Organic Frameworks and Graphite (2017)

The synthetically tunable properties and intrinsic porosity of conductive metal-organic frameworks (MOFs) make them promising materials for transducing selective interactions with gaseous analytes in an electrically addressable platform. Consequently, conductive MOFs are valuable functional materials with high potential utility in chemical detection. The implementation of these materials, however, is limited by the available methods for device incorporation due to their poor solubility and moderate electrical conductivity. This manuscript describes a straightforward method for the integration of moderately conductive MOFs into chemiresistive sensors by mechanical abrasion. To improve electrical contacts, blends of MOFs with graphite were generated using a solvent-free ball-milling procedure. While most bulk powders of pure conductive MOFs were difficult to integrate into devices directly via mechanical abrasion, the compressed solid-state MOF/graphite blends were easily abraded onto the surface of paper substrates equipped with gold electrodes to generate functional sensors. This method was used to prepare an array of chemiresistors, from four conductive MOFs, capable of detecting and differentiating NH₃, H₂S and NO at parts-per-million concentrations.
Application of 0-1 integer programming to multitarget tracking problems (1977)

This paper presents a new approach to the solution of multi-target tracking problems. 0-1 integer programming methods are used to alleviate the combinatorial computing difficulties that accompany any but the smallest of such problems. Multitarget tracking is approached as an unsupervised pattern recognition problem. A multiple-hypothesis test is performed to determine which particular combination of the many feasible tracks is most likely to represent actual targets. This multiple hypothesis test is shown to have the computational structure of the set packing and set partitioning problems of 0-1 integer programming. Multitarget tracking problems that are translated into this form can be rapidly solved, using well-known discrete optimization techniques such as implicit enumeration.
The mammalian circadian clock in the suprachiasmatic nuclei is reset in vitro by cAMP (1989)

A circadian clock located in the suprachiasmatic nuclei (SCN) of the hypothalamus controls the daily behavioral and physiological rhythms of mammals. While the mammalian circadian system has been the focus of research for many years, very little work has been directed at understanding its underlying biochemical mechanisms. In these experiments we used the hypothalamic brain slice technique to investigate these mechanisms, focusing specifically on the intrinsic resetting properties of the circadian clock of the rat. We monitored a primary expression of the clock or pacemaker, the circadian rhythm of electrical activity of SCN neurons. This rhythm continues the oscillatory pattern seen in vivo for up to 60 hr in vitro, with an activity peak near midday that shows very little variation among SCN from different rats. The stability of the rhythm in vitro enabled us to use the time of peak activity to monitor the phase of the underlying pacemaker. Bath application of membrane-soluble cAMP analogs in 1 hr pulses induced robust advances in the phase of the rhythm that remained stable for 2 cycles. This effect depended on the phase of the pacemaker at the time of treatment: the peak was maximally advanced (4-6 hr) by treatments during the middle of the subjective day (projected from the donor's cycle); treatments during most of the subjective night and early subjective day induced no phase changes. Half-maximal phase resetting was induced at 1 x 10(-10) M concentrations of active cAMP analog.(ABSTRACT TRUNCATED AT 250 WORDS)
Practical Entropy-Compressed Rank/Select Dictionary (2007)

Rank/Select dictionaries are data structures for an ordered set S ⊂ {0,1,…, n − 1} to compute runk(x, S) (the number of elements in S that are no greater than x), and select(i, S) (the i-th smallest element in S), which are the fundamental components of succinct data structures of strings, trees, graphs, etc‥ In these data structures, however, only asymptotic behavior has been considered and their performance for real data is not satisfactory. In this paper, we propose four novel Rank/Select dictionaries: esp, recrank, vcode and sdarray, each of which is small if the number of elements in S is small, and indeed close to nH0(S) (H0(S) < 1 is the zero-th order empirical entropy of S) in practice. Furthermore, their query times are superior to those of existing structures. Experimental results reveal the characteristics of our data structures and also show that these data structures are superior to existing implementations, both in terms of size and query time.
Value and Limitations of Thallium-201 Scintigraphy in the Acute Phase of Myocardial Infarction (1976)

We examined the diagnostic usefulness of thallium-201 scintigraphy in 200 patients with acute myocardial infarction. The scintiscans showed a defect, suggesting infarction in 165. In all 44 patients studied iwthin six hours after onset of symptoms the scintiscans indicated a defect. Frequency of positive scans was significantly higher (90 of 96) in patients studied within 24 hours after onset than in those (75 of 104) studied later (p less than 0.01).
A Specific Role for AKT3 in the Genesis of Ovarian Cancer through Modulation of G2-M Phase Transition (2006)

Ovarian cancer is the major cause of death from gynecological malignancy, and there is an urgent need for new therapeutic targets. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been strongly implicated in the genesis of ovarian cancer. However, to identify and evaluate potential targets for therapeutic intervention, it is critical to understand the mechanism by which the PI3K/AKT pathway facilitates ovarian carcinogenesis. Here, we show that AKT3 is highly expressed in 19 of 92 primary ovarian tumors. Strikingly, purified AKT3 exhibited up to 10-fold higher specific activity than AKT1, potentially amplifying the effects of AKT3 overexpression. Consistent with this finding, AKT3 levels in a range of ovarian cancer cell lines correlated with total AKT activity and proliferation rates, implicating AKT3 as a key mediator of ovarian oncogenesis. Specific silencing of AKT3 using short hairpin RNA markedly inhibited proliferation of the two cell lines with highest AKT3 expression and total AKT activity, OVCA429 and DOV13, by slowing G(2)-M phase transition. These findings are consistent with AKT3 playing a key role in the genesis of at least one subset of ovarian cancers.
Bringing Stories Alive: Generating Interactive Fiction Worlds (2020)

Interactive fictions—also called text-based games—are games in which a player interacts with a virtual world purely through textual natural language. In this work, we focus on procedurally generating interactive fiction worlds. Generating these worlds requires (a) referencing everyday and thematic commonsense priors in addition to (b) being semantically consistent, (c) interesting, (d) coherent throughout, all while (e) producing fluent natural language descriptions of places, people, and things. Using existing story plots from books as inspiration, we present a method that first extracts a partial knowledge graph encoding basic information regarding world structure such as locations and objects. This knowledge graph is then automatically completed utilizing thematic knowledge and used to guide a neural language generation model that fleshes out the rest of the world. We evaluate generated worlds with human-participant studies, comparing our technique against rule-based and human-made baselines
A systematic review of small group communication in post-secondary online courses (2012)

The purpose of this systematic review is to establish a comprehensive understanding of research trend and findings of the current studies focused on small group communication in post-secondary online courses. Comprehensive searching electronic databases and step-by-step screening procedures were performed to locate a total of eighteen journal articles published in 2000-2009 as a final data included in the review. Two independent reviewers coded the studies completely, which were mapped inductively into four main categories based on common themes of their research focuses. The findings of individual studies were sub-categorized, synthesized, and summarized. To conclude, the review provides major findings extracted from the eighteen studies and discusses gaps and limitations of existing studies to make some suggestions for future research.
Bordetella pertussis and Chronic Cough in Adults (1999)

To evaluate Bordetella pertussis as a cause of persistent cough in adults, we examined 201 patients who had a cough for 2-12 weeks and no pulmonary disease. We obtained the following at presentation: medical history, chest radiograph, respiratory function measurement, nasopharyngeal aspirate for polymerase chain reaction (PCR), nasopharyngeal swab specimen for culture, and a blood sample (acute serum). Four weeks later a second blood sample (convalescent serum) was obtained. Control sera were obtained from 164 age-matched healthy blood donors with no history of cough during the previous 12 weeks. Four patients were B. pertussis culture-positive; 11 (including the culture-positive patients) were B. pertussis PCR-positive; and 33, including 10 of the 11 PCR-positive patients, had serological evidence of recent B. pertussis infection. Pertussis-positive and -negative patients could not be discriminated by a history of cough. We conclude that B. pertussis infection is a common cause of persistent cough in adults. This is of concern, because these patients may be B. pertussis reservoirs from which transmission may occur to infants, in whom the disease can be devastating.