gebhart/patrepeval huggingface dataset:
Analysis of the anti-p53 antibody response in cancer patients. (1993)

Mutations in the p53 tumor suppressor gene giving rise to mutant p53 proteins are among the most common genetic alterations associated with tumor cells. Mutant p53 gene products lose the wild type ability to suppress transformation in vitro or regulate cellular gene transcription. Mutant and wild type p53 protein conformations differ and mutant p53 is often present at high levels in the tumor cell relative to the low levels found in normal cells. Despite the major advances made to characterize the structure and biology of mutant and wild type p53, the humoral immune response against mutant p53s remains to be clearly defined. In the present study we have examined the anti-p53 response from cancer patients against the native and denatured state of mutant and wild type p53. Western blot analysis, immunoprecipitation analysis, and dilution analysis demonstrate that the anti-p53 sera recognize both wild type and mutant p53 conformational and denaturation resistant epitopes. There was no evidence that the mutant p53 molecules contain dominant antigenic epitopes which are not present on the wild type p53 protein. We also demonstrate that patients with ovarian cancer are also among those which can produce anti-p53 antibodies.
Rayleigh scattering of silica core optical fiber after heat treatment (1998)

We investigated the Rayleigh scattering of silica core optical fibers, parts of which were heat treated at various temperatures, in relation to their fictive temperatures (T(f)). The scattering intensities from short fiber segments were clearly reduced by heat treatment compared with those of the unheated parts. The T(f) values of the heated parts of the fibers were determined by measuring the infrared reflection spectrum for cleaved end surfaces and were also reduced by controlling the heating temperature. The reduction in the scattering intensity correlates well with the reduction in T(f).
Band-structure description of Mott insulators (NiO, MnO, FeO, CoO) (1990)

The unoccupied-states potential correction (USPC) in the local spin-density-functional (LSDF) formalism is proposed as a way to take correlation effects into account approximately. The method is based on using different potentials for the electrons in valence and conduction bands. When applied to antiferromagnetic transition-metal oxides (NiO, MnO, FeO, CoO), it solved the long-standing problem of reproducing the experimental values of the band gaps, which are underestimated in normal LSDF calculations. FeO and CoO become insulators, in contrast to the metallic ground state obtained in the usual LSDF calculations. Moreover, the calculated magnetic properties improved considerably due to the introduction of the USPC. It is shown that band-structure calculations using the USPC provide a correct description of available data from spectral measurements (ultraviolet photoelectron spectroscopy, X-ray photoelectron spectroscopy, bremsstrahlung isochromate spectroscopy) for these compounds.
Using likely invariants for automated software fault localization (2013)

We propose an automatic diagnosis technique for isolating the root cause(s) of software failures. We use likely program invariants, automatically generated using correct inputs that are close to the fault-triggering input, to select a set of candidate program locations which are possible root causes. We then trim the set of candidate root causes using software-implemented dynamic backwards slicing, plus two new filtering heuristics: dependence filtering, and filtering via multiple failing inputs that are also close to the failing input. Experimental results on reported software bugs of three large open-source servers show that we are able to narrow down the number of candidate bug locations to between 5 and 17 program expressions, even in programs that are hundreds of thousands of lines long.
Conical Boron Nitride Nanorods Synthesized Via the Ball‐Milling and Annealing Method (2005)

A boron nitride (BN) nanostructure, conical BN nanorod, has been synthesized in a large quantity on Si substrates for the first time via the ball‐milling and annealing method. Nitridation of milled boron carbide (B 4 C) powders was performed in nitrogen gas at 1300°C on the surface of the substrates to form the BN nanorods. The highly crystallized nanorods consist of conical BN basal layers stacked along the nanorod axis. Ball milling of the B 4 C powders can significantly enhance the nitridation of the powders and thus facilitate the formation of nanorods during the annealing process.
<scp>GPBA</scp>: a <scp>GPCR</scp> for bile acids and an emerging therapeutic target for disorders of digestion and sensation (2013)

Bile acids (BAs) are digestive secretions that are necessary for the emulsification and absorption of dietary fats. Given the episodic nature of BA secretion and intestinal re-absorption, the circulating and tissue levels of BAs, like those of the gut hormones, fluctuate in fasting and fed states, and BA levels and forms are markedly affected by disease. BAs exert widespread hormonal-like effects by activating receptors in the nucleus and at the plasma membrane. The nuclear steroid receptors mediate the genomic actions of BAs on BA, glucose and lipid homeostasis. GPBA (TGR5) is a G-protein coupled plasma membrane receptor for BAs that mediates many of the rapid, non-genomic actions of BAs. GPBA has been implicated in the control of glucose homeostasis, inflammation and liver functions. Recent observations have revealed an unexpected role for GPBA in the nervous system. GPBA is expressed by enteric neurons and enterochromaffin cells that control peristalsis, and GPBA mediates the prokinetic actions of BAs in the colon that have been known for millennia. GPBA is also present on primary spinal afferent and spinal neurons that are necessary for sensory transduction. BA-induced activation of GPBA in the sensory nervous system promotes scratching behaviours and analgesia, which may contribute to the pruritus and painless jaundice that are observed in some patients with chronic cholestatic disease, where circulating BA concentrations are markedly increased. Thus, GPBA has emerged as an intriguing target for diverse metabolic, inflammatory, digestive and sensory disorders, where agonists and antagonists may be of value.
A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the Proliferation, Immune response and RNA splicing modules in breast cancer (2008)

The study revealed that the nine signatures perform similarly but exhibit a large degree of discordance in prognostic group assignment. Functional analyses indicate that proliferation is a common cellular process, but that other functional categories are also enriched and show independent prognostic ability. We provide new evidence of the potentially promising prognostic impact of immunity and RNA-splicing processes in breast cancer.
Effects of Naloxone on Opioid-induced Hyperalgesia and Tolerance to Remifentanil under Sevoflurane Anesthesia in Rats (2013)

An ultra-low dose of naloxone blocked remifentanil-induced hyperalgesia but did not change opioid tolerance under inhalant anesthesia. Moreover, the MAC increase associated with hyperalgesia was also blocked by naloxone.
Soluble NKG2D ligands in hepatic autoimmune diseases and in benign diseases involved in marker metabolism. (2007)

While hepatic autoimmune diseases have no general impact on the amount of circulating sMICA and sMICB, acute bacterial infections, renal insufficiency and cholestasis can lead to notably elevated serum levels of the NKG2D ligands.
Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif (1990)

A human term placental cDNA library was screened at low stringency with a human prolactin cDNA probe. One of the cDNAs isolated hybridizes to a 1.8 kb mRNA present in all four tissues of the placenta as well as to every nucleated tissue and cell line tested. The sequence of the full-length cDNA was determined. An extended open reading frame predicted an encoded protein product of 20.5 kDa. This was directly confirmed by the in vitro translation of a synthetic mRNA transcript. Based upon the characteristic placement of cysteine (C) and histidine (H) residues in the predicted protein structure, this molecule contains four putative zinc fingers. The first and third fingers are of the C4 class while the second and fourth are of the C2HC class. Based upon sequence similarities between the first two and last two zinc fingers and sequence similarities to a related rodent protein, cysteine-rich intestinal protein (CRIP), these four finger domains appear to have evolved by duplication of a preexisting two finger unit. Southern blot analyses indicate that this human cysteine-rich protein (hCRP) gene has been highly conserved over the span of evolution from yeast to man. The characteristics of this protein suggest that it serves a fundamental role in cellular function.
Effect of form of the surface reactivity of differently prepared zinc oxides (1989)

The relationships between the from of crystallites and their adsorption properties have been investigated on ZnO samples of various origins by means of electron microscopy, X-ray diffraction and adsorption calorimetry. Three polycrystalline ZnO samples have been studied: one obtained by ignition of zinc metal (Kadox) and the others obtained by decompositon of zinc carbonate and oxalate. The higher surface reactivity found on Kadox ZnO in comparison with that found on ex-salt ZnO is not due to the preferential development of crystal planes at the surface but to the presence of better defined single microcrystals with sharp edges. In all the cases examined the preparation route leads to a difference in morphology and consequently a difference in reactivity. Carbon monoxide and hydrogen have been used as surface probes for active sites: CO is coordinated onto cations exposed at the edges between the (0001) and (10text-decoration:overline10) planes; H2 is adsorbed in different forms, one of which, type I, occurs on sites located at the same edge as CO. Prereduction of ZnO reduces the adsorption activity towrds both gases; the extent of this reduction also depends upon the actual morphology.
Hue shifts in unrelated and related colours (1989)

Abstract Published data on the dependence of hue on luminance (the Bezold‐Brücke effect) is analysed in terms of changes of hue angle instead of changes in wavelength so as to assess their visual importance. For unrelated colours, for a given monochromatic wavelength, the changes in hue caused by altering the luminance vary appreciably according to whether the colours are seen side‐by‐side continuously, or side‐by‐side in flashes, or one‐at‐a‐time in flashes. For related colours, for a given chromaticity, the changes in hue caused by changing the luminance factor are examined in the Munsell and NCS systems; although systematic variations occur, they are different in the two systems, and in neither case is there any similarity to the situation for unrelated colours. Changes in illuminance on related colours do not seem to have any systematic effect on hue for a given chromaticity. It is concluded that the Bezold‐Brücke effect for unrelated colours is not relevant when related colours are considered.
FutureGrid Image Repository: A Generic Catalog and Storage System for Heterogeneous Virtual Machine Images (2011)

Future Grid (FG) is an experimental, high-performance test bed that supports HPC, cloud and grid computing experiments for both application and computer scientist. Future Grid includes the use of virtualization technology to allow the support of a wide range of operating systems in order to include a test bed for various cloud computing infrastructure as a service frameworks. Therefore, efficient management of a variety of virtual machine images becomes a key issue. Current cloud frameworks do not provide a way to manage images for different IaaS frameworks. They typically provide their own image repositories, but in general they do not allow us to store the needed metadata to handle other IaaS images. We present a generic catalog and image repository to store images of any type. Our image repository has a convenient interface that distinguishes image types. Therefore, it is not only useful for Future Grid, but also for any application that needs to manage images.
Rail and armature current distributions in electromagnetic launchers (1982)

The current and magnetic field distributions in the rails and armature of an electromagnetic launcher are obtained in closed form for the steady state. These solutions assume that the armature moves with a steady velocity and account fully for the two-dimensional skin effect caused by the relative motion between the rails and the armature. Both solid and laminated armatures are considered. It is found in the case of the laminated armature that the phenomenon can be described by a single dimensionless parameter, <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\frac{\ell}{w}\frac{\sigma_{o}}{\sigma_{r}}\sqrt{\frac{u\ell}{\pi\eta_{r}}}</tex> .
Reduction of ovarian adhesions by the use of interceed (1995)

Treatment of ovaries with Interceed significantly reduced the occurrence and severity of postsurgical ovarian adhesions.
A spin rotator for spin-polarized scanning electron microscopy (2004)

A Wien filter, which is a common energy analyzer, was modified as a spin rotator for use in a spin-polarized scanning electron microscope. By switching the spin rotator on and off, magnetic domain images of all three magnetization vectors can be produced in one scan. The electrodes and the magnetic pole pieces were specially designed by using a three-dimensional computer simulation for electric and magnetic fields, electron trajectories, and spin rotation; the broad beam of the secondary electrons passes through to the spin detector with a 90° rotation. The structure is simple with only two electrodes that have hyperbolically curved surfaces to create a stigmatic focusing effect, while the surfaces of the magnetic pole pieces are flat to enable a uniform rotation of all electron spins. The performance was tested and confirmed to be effective by observing the magnetic domain structures of Fe(001) with in-surface-plane magnetization and a TbFeCo magneto-optical medium with surface normal magnetization.
A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity (2008)

A conundrum of innate antiviral immunity is how nucleic acid-sensing Toll-like receptors (TLRs) and RIG-I/MDA5 receptors cooperate during virus infection. The conventional wisdom has been that the activation of these receptor pathways evokes type I IFN (IFN) responses. Here, we provide evidence for a critical role of a Toll-like receptor 3 (TLR3)-dependent type II IFN signaling pathway in antiviral innate immune response against Coxsackievirus group B serotype 3 (CVB3), a member of the positive-stranded RNA virus family picornaviridae and most prevalent virus associated with chronic dilated cardiomyopathy. TLR3-deficient mice show a vulnerability to CVB3, accompanied by acute myocarditis, whereas transgenic expression of TLR3 endows even type I IFN signal-deficient mice resistance to CVB3 and other types of viruses, provided that type II IFN signaling remains intact. Taken together, our results indicate a critical cooperation of the RIG-I/MDA5-type I IFN and the TLR3-type II IFN signaling axes for efficient innate antiviral immune responses.
Magnetic Fields and Reactive Oxygen Species (2017)

Reactive oxygen species (ROS) ubiquitously exist in mammalian cells to participate in various cellular signaling pathways. The intracellular ROS levels are dependent on the dynamic balance between ROS generation and elimination. In this review, we summarize reported studies about the influences of magnetic fields (MFs) on ROS levels. Although in most cases, MFs increased ROS levels in human, mouse, rat cells, and tissues, there are also studies showing that ROS levels were decreased or not affected by MFs. Multiple factors could cause these discrepancies, including but not limited to MF type/intensity/frequency, exposure time and assay time-point, as well as different biological samples examined. It will be necessary to investigate the influences of different MFs on ROS in various biological samples systematically and mechanistically, which will be helpful for people to get a more complete understanding about MF-induced biological effects. In addition, reviewing the roles of MFs in ROS modulation may open up new scenarios of MF application, which could be further and more widely adopted into clinical applications, particularly in diseases that ROS have documented pathophysiological roles.
Ontario Child Health Study: Prevalence of Attention Deficit Disorder with Hyperactivity (1989)

The objective of this paper is to present data from the Ontario Child Health Study on the prevalence of attention deficit disorder with hyperactivity (ADDH). The overall prevalence of ADDH was 9.0% in boys and 3.3% in girls. There were no significant differences in the prevalence of ADDH by age or urban-rural status, but the disorder was significantly more common in boys than in girls. The prevalence of various subtypes of ADDH was also explored: attention deficit with and without hyperactivity, situational vs pervasive ADDH, and ADDH with and without other disorders. The clinical implications of these findings are discussed.
Asymmetric Organocatalytic Protonation of Silyl Enolates Catalyzed by Simple and Original Betaines Derived from <i>Cinchona</i> Alkaloids (2013)

Abstract The asymmetric protonation of silyl enolates derived from tetralone, benzosuberone, and cyclohexanone has been successfully achieved by using simple and original betaine catalysts derived from Cinchona alkaloids (quinine and quinidine series) to afford the desired α‐substituted ketones in high yields and moderate enantioselectivities. The ease of implementation of this approach along with the easy accessibility of the betaine catalyst (four steps from cheap and commercially available quinine or quinidine) make this approach very appealing for the preparation of enantioenriched α‐monosubstituted carbonyl compounds.
Intrathecal trastuzumab: immunotherapy improves the prognosis of leptomeningeal metastases in HER-2+ breast cancer patient (2015)

We describe the clinical and therapeutic course of a 51-year-old woman with HER-2+ breast cancer who developed leptomeningeal (LM) and spinal cord metastases after 8 years of stable disease on combination therapy with intravenous (IV) trastuzumab. Due to progressive CNS disease, intrathecal (IT) trastuzumab was introduced to enhance HER-2+ therapy into the CSF space. A combination HER-2+ targeted approach achieved clinical remission with stable disease in our patient 46 months after she was diagnosed with LM metastases. However, spinal cord C-1 metastasis was not fully controlled with IT trastuzumab, ultimately leading to the patient's respiratory compromise. In our patient, IT trastuzumab immunotherapy improved prognosis and was an effective strategy to manage HER-2+ LM disease. Given alone or alongside other anti-HER-2+ therapeutics with sufficient CNS penetration, IT trastuzumab could extend the lifespan of patients with leptomeningeal and CNS metastases.
Flashover in picture tubes and methods of protection (1969)

The aim of this paper is to bring forward and analyse phenomena occurring in a television receiver as a result of a flashover inside a picture tube, and to evolve a systematic approach to a method of protection. The paper first reviews the behaviour of a picture tube under flashover conditions, its effect on receiver circuitry, and a suggestion is made for a possible equivalent circuit. It then establishes a comprehensive method of protection against the large transients generated by a flashover which affect primarily a portion of the receiver directly connected to the base of the picture tube. This protection consists of a separate path for flashover currents, which is switched into circuit for the duration of flashover by means of spark-gaps assisted by series resistors. It is connected in such a way as to provide a minimum disturbance to the rest of the receiver. Further, the paper considers overloads imposed on the e.h.t. generator as a result of discharge of the e.h.t. capacitor by a flashover of the picture tube or other agency. Proposals are made for suitable limiters to protect the output transistor. Finally, a description of some measuring techniques of particular interest in flashover work is given.
Materials and Compounds (2012)

No AccessEngineering with RubberFeb 2012Materials and CompoundsG. R. HamedG. R. HamedSearch for more papers by this authorhttps://doi.org/10.3139/9783446428713.002SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2011Pages: 11-36Print ISBN: 978-3-446-42764-8eISBN: 978-3-446-42871-3 Copyright & Permissions© 2012 Carl Hanser Verlag GmbH & Co. KGPDF DownloadLoading ...
Purification to Homogeneity of Pyrroline-5-Carboxylate Reductase of Barley (1986)

An enzyme has been purified to homogeneity from barley seedlings which has ;proline dehydrogenase' and the pyrroline-5-carboxylic acid reductase activities. The purification achieved is 39,000-fold as calculated from the proline dehydrogenase activity. The subunit molecular weight of the protein is 30 kilodaltons. The native enzyme has molecular weights up to 480 kilodaltons, depending on the buffer environment. From the pH profiles, the specific activities and thermodynamic considerations, it is concluded that the plant proline dehydrogenase functions in vivo as a pyrroline-5-carboxylate reductase.
Effect of Probiotic on Some Physiological Parameters in Broiler Breeders (2011)

The study was conducted to evaluate the effect of probiotic diet supplementation on som e physiological parameters in Broiler Breeders. 30 Cobb Breeder hens were used (46 week aged), divided into 3 groups (10 hens each). The 1st group was reared on standard ration (control), the 2nd and the 3rd groups were given 10 and 20 gm of probiotic/kg ration for 4 weeks. The results revealed that the probiotic treatment causes a significant increase in LH and FSH serum levels (3rd group) and in T3 levels in (2nd and 3rd group) as compared with control group at p <0.05. Also the probiotic treatment causes a significan t decrease in serum triglyceride levels and a significant increase in serum Uric acid level as compared with control. The above effects reflected in improvement of the egg weight, yolk weight and egg production % as compared with control. In conclusion, the probiotic supplementation of Broiler Breeders diet will improve the hormonal status and enhance the productivity.