gebhart/patrepeval huggingface dataset:
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas (2016)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTNext Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic AreasYu Zhou†, Jiang Wang†, Zhanni Gu†, Shuni Wang†, Wei Zhu†, José Luis Aceña*‡§, Vadim A. Soloshonok*‡∥, Kunisuke Izawa*⊥, and Hong Liu*†View Author Information† Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China‡ Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain§ Department of Organic Chemistry, Autónoma University of Madrid, Cantoblanco, 28049 Madrid, Spain∥ IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, 48013 Bilbao, Spain⊥ Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka, Japan 533-0024*E-mail: [email protected]*E-mail: [email protected]*E-mail: [email protected]*E-mail: [email protected]Cite this: Chem. Rev. 2016, 116, 2, 422–518Publication Date (Web):January 12, 2016Publication History Received6 July 2015Published online12 January 2016Published inissue 27 January 2016https://pubs.acs.org/doi/10.1021/acs.chemrev.5b00392https://doi.org/10.1021/acs.chemrev.5b00392review-articleACS PublicationsCopyright © 2016 American Chemical SocietyRequest reuse permissionsArticle Views31495Altmetric-Citations2070LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical structure,Fluorine,Inhibitors,Pharmaceuticals,Reaction products Get e-Alerts
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily (1991)

The present study characterizes the profile of cDNAs from the human P450IIC subfamily in a library from one individual, and it describes three new members of this subfamily (IIC17, IIC18, and IIC19) isolated from two human cDNA libraries. cDNA libraries were constructed from two human livers which differed phenotypically in the hepatic content of P450 HLx (IIC8). The library from the phenotypically low HLx individual was screened by using a cDNA for rat liver P450IIC13 and an oligonucleotide probe for human IIC8. One clone, 245c, was isolated which clearly represents a new member of the human P450IIC subfamily (IIC17). This clone lacked the first 358 nucleotides at the N-terminus but was only 91% homologous in its nucleic acid sequence to IIC9 and 79% homologous to IIC8. Near-full-length clones for IIC9 were also isolated from this library, but no clones for IIC8 were found. Northern blots indicated that the mRNA for IIC8 was low or absent in this individual. A second cDNA library (from a liver phenotypically high in HLx) was then screened. Eighty-three essentially full-length (greater than 1.8 kb) clones belonging to the IIC subfamily were isolated from this library. These include full-length clones for two additional new members of the IIC subfamily. Clones 29c and 6b appear to be allelic variants (IIC18), differing by one nucleotide (one amino acid change) in the coding region. Clone 11a represents a full-length clone for a third new P450 (IIC19).(ABSTRACT TRUNCATED AT 250 WORDS)
A study of decompiling machine languages into high-level machine independent languages (1973)

Abstract not available
El pensamiento operativo en el ejército alemán (1999)

La operacion Tormenta de/ Desierto (Deseti Storm) (1991) constato, que las ensenanzas militares y en particular las operacionales del ataque aleman ejecutado en mayo de 1940 en direccion Oeste siguen vigentes. Expresado de una manera simplificada: coordinar la mision recibida del mando politico con el empleo de las fuerzas en un marco espacial y temporal determinado, optando siempre por la via que, dentro de un amplio abanico de posibilidades, garantice el maximo exito, es el rasgo distintivo de la esencia y la tarea del mando y pensamiento operacionales.
Evaluation of Allelic Expression of Imprinted Genes in Adult Human Blood (2010)

We conclude that only a limited set of imprinted genes, including IGF2 and SNRPN, may be useful for LOI cancer biomarker studies. In addition, blood is not a good tissue to use for the discovery of new imprinted genes. Finally, lymphocyte DNA methylation status in the adult may not always be a reliable indicator of monoallelic gene expression.
Design and evaluation of the distributed software component framework for distributed communication architectures (2002)

We present our experiences with the DSC (Distributed Software Component) framework and development environment. The DSC framework supports component oriented distributed communication architecture such as TINA (Telecommunications Information Network Architecture). Within the component development environment, components can be developed and evaluated. Software components are self-contained packages of code that can be dynamically linked into a program. Operational interfaces cater for the external functionality of the component. The DSC can support both dynamic and static operational interfaces. Also, there can exist multiple instances of the same operational interface. Furthermore, components can be grouped together to form compound components. Through a common control and configuration interface the components can be configured with regard to events, properties, operational interfaces life cycle, and composition. We apply this framework to a TINA based service and network architecture called MESH (Multimedia Services an the Electronic Super Highway). An example is provided; a shared white board service is created using the DSC framework. The shared white board service can be used in multimedia conferencing applications.
Multi-step binary-weighted capacitive digital-to-analog converter architecture (2008)

We present a capacitive digital-to-analog converter (DAC) architecture combining properties of the binary-weighted and serial charge-redistribution DACs to yield high integration density and high accuracy. The architecture provides the flexibility to trade area with conversion speed based on a set of area-speed-linearity constraints. We validate the architecture using a 10-bit two-step DAC example, simulated in a standard 0.35 mum CMOS technology. The 10-bit DAC occupies 32 times less area than the conventional 10-bit binary-weighted DAC, has low INL, good matching, and high tolerance to parasitic capacitance.
Percutaneous Needle Fasciotomy Versus Collagenase Treatment for Dupuytren Contracture (2018)

Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Acoustic surface-wave transversal filters (1973)

Some basic concepts of transversal filters are reviewed. Transversal-filter structures provide a conceptually simple way for obtaining a wide range of transfer functions. However, the practical realization of such filters has, in the past, required very complex or bulky circuits because of the necessary delay line and because of the many taps and attenuators that may be needed. However, interdigital acoustic surface-wave transducers on piezoelectric substrates are seen to provide a very compact and attractive way to realize transversal filters. Acoustic waves in a solid have an extremely low velocity as compared with electromagnetic (EM) waves, so that the acoustic surface waves on the substrate provide a very compact delay line. Further, the desired set of weighted taps is readily achieved by a photoetched array of metallic fingers. Fringing electric fields from these fingers tap into the acoustic surface-wave delay line by way of the piezoelectric effect. Equivalent circuits for interdigital acoustic surface-wave transducers are discussed and equations for their transfer and input-impedance properties are presented. The application of interdigital transducers for use as conventional filters, pulse-compression filters, and general matched filters is briefly described.
Formal specification of N-modular redundancy (1986)

Article Free Access Share on Formal specification of N-modular redundancy Authors: L. Mancini Computing Laboratory, The University, Newcastle upon Tyne, NE1 7RU, U.K. Computing Laboratory, The University, Newcastle upon Tyne, NE1 7RU, U.K.View Profile , M. Koutny Computing Laboratory, The University, Newcastle upon Tyne, NE1 7RU, U.K. Computing Laboratory, The University, Newcastle upon Tyne, NE1 7RU, U.K.View Profile Authors Info & Claims CSC '86: Proceedings of the 1986 ACM fourteenth annual conference on Computer scienceFebruary 1986 Pages 199–204https://doi.org/10.1145/324634.325389Published:01 February 1986Publication History 4citation326DownloadsMetricsTotal Citations4Total Downloads326Last 12 Months9Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Database techniques for archival of solid models (2001)

This paper presents techniques for managing solid models in modern relational database management systems. Our goal is to enable support for traditional database operations (sorting, distance metrics, range queries, nearest neighbors, etc) on large databases of solid models. As part of this research, we have developed a number of novel storage and retrieval strategies that extend the state-of-the-art in database research as well as change the way in which solid modeling software developers and design and manufacturing enterprises view CAD-centric data management problems.
Reactivity of Leu-1+ tonsillar B cells to a high molecular weight B cell growth factor. (1987)

This work was focused on the responsiveness of B cells from blood and tonsils to typical B cell growth factors (BCGF) in the absence of anti-mu antibody. This direct responsiveness was not observed with small dense B cells from either organ. Large tonsillar B cells but not large blood B cells did respond directly to a high m.w. BCGF (m.w. 50,000 BCGF), whereas large B cells from both organs responded directly to the low m.w. BCGF (m.w. 20,000 BCGF). The tonsillar B cells directly responsive to the m.w. 50,000 BCGF express the 4F2 marker and thus belong to a population of in vivo-preactivated B cells. Moreover, this direct responsiveness to the m.w. 50,000 BCGF is localized in Leu-1+ tonsillar B cells. The Leu-1+ and Leu-1- tonsillar B cell subsets do not differ in their responsiveness to the m.w. 50,000 BCGF upon costimulation with anti-mu antibody and to the m.w. 20,000 BCGF regardless of the presence of anti-mu antibody. Thus, the Leu-1+ subset present in tonsils shows a particular reactivity to a high m.w. BCGF.
Web and Exchange in BP's intranet (1997)

Focuses on British Petroleum's introduction and use of World Wide Web technologies internally in BP's intranet. It considers the benefits expected of an intranet within the BP context, looks at the approach taken to its roll-out throughout the company, outlines some of the applications to which the Web is being put, draws out some of the lessons learned from BP's experience, and looks at some future opportunities. BP's roll-out of the Web coincided with (and became part of) a wider change in its IT infrastructure: the introduction of its new Common Operating Environment (COE), which includes the provision of Microsoft Exchange to all BP's desktops. Both the Web and Exchange provide users with the means of publishing documents to a large number of people across the BP Group. The paper also positions these technologies and discusses some of ways in which the Web and Exchange are being integrated and used in collaboration to deliver value to the company.
Expanding the Diversity of Mycobacteriophages: Insights into Genome Architecture and Evolution (2011)

Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable, and although sixty-two genomes have been sequenced and comparatively analyzed, these likely represent only a small portion of the diversity of the mycobacteriophage population at large. Here we report the isolation, sequencing and comparative genomic analysis of 18 new mycobacteriophages isolated from geographically distinct locations within the United States. Although no clear correlation between location and genome type can be discerned, these genomes expand our knowledge of mycobacteriophage diversity and enhance our understanding of the roles of mobile elements in viral evolution. Expansion of the number of mycobacteriophages grouped within Cluster A provides insights into the basis of immune specificity in these temperate phages, and we also describe a novel example of apparent immunity theft. The isolation and genomic analysis of bacteriophages by freshman college students provides an example of an authentic research experience for novice scientists.
Recent trends of reuse of recording paper and reversible recording media. (1993)

With the progress of an "information-based" society, the popularity of various OA equipment has become wide-spread, and consequently, significant volumes of information forms and paper are used and wasted. Efficient use of recycled paper for information forms and paper faced with a strng demand from the perspective of environmental preservation and garbage disposal problems. There has been an advance in the technology to process waste paper for reuse, and organization of a recycling system is already under way. Recently, apart from recycling of paper itself, many reports have been made which concern the use of reversible recording media. This report introduces the general and technical trends for the use of reversible recording media as one possible replacement to information forms and paper, and briefly discusses future hopes in this aspect.
Significance of Hydrogen Control in the Welding of Low Alloy Steels (1984)

As a joining operation, welding plays by far the most important role in the fabrication industry. To keep the rejection rates low, quality of welding has to be of the highest order. The present paper deals with the role of hydrogen in the welding of low alloy steels.
Integrated terahertz source based on three-wave mixing of whispering-gallery modes (2008)

We propose an integrated terahertz emitter operating at room temperature between 2.4 and 6 THz. Based on difference-frequency generation in a triply resonant Au/AlAs/GaAs/AlAs/Au microcylinder, this nonlinear source is pumped by two near-IR whispering-gallery modes that are excited by InAs quantum dots embedded in the resonator. In the vertical direction, these pump modes are due to total internal reflection at GaAs/AlAs interfaces, while the terahertz mode is confined between the metallic layers. This parametric source offers potential advantages with respect to existing terahertz sources for spectroscopic applications, such as room-temperature operation and electrical pumping.
Boosting constrained mutual subspace method for robust image-set based object recognition (2009)

Object recognition using image-set or video sequence as input tends to be more robust since image-set or video sequence provides much more information than single snap-shot about the variability in the appearance of the target subject. Constrained Mutual Subspace Method (CMSM) is one of the state-of-the-art algorithms for imageset based object recognition by first projecting the image-set patterns onto the so-called generalized difference subspace then classifying based on the principal angle based mutual subspace distance. By treating the subspace bases for each image-set patterns as basic elements in the grassmann manifold, this paper presents a framework for robust image-set based recognition by CMSMbased ensemble learning in a boosting way. The proposed Boosting Constrained Mutual Subspace Method(BCMSM) improves the original CMSM in the following ways: a) The proposed BCMSM algorithm is insensitive to the dimension of the generalized differnce subspace while the performance of the original CMSM algorithm is quite dependent on the dimension and the selecting of optimum choice is quite empirical and case-dependent; b) By taking advantage of both boosting and CMSM techniques, the generalization ability is improved and much higher classification performance can be achieved. Extensive experiments on real-life data sets (two face recognition tasks and one 3D object category classification task) show that the proposed method outperforms the previous state-ofthe-art algorithms greatly in terms of classification accuracy. 1
Digital library for mulsemedia content management (2010)

Digital Libraries are key infrastructure for document management. Until now, these documents have included multimedia objects such video, images, text, sounds. In this paper, we focus on enhanced sensorial media content management in Digital Library. Enhanced sensorial media content combines the sense of touch with other media. All mulsemedia content management requires new methods, starting from the source through storage to delivery. Digital libraries have to use all modern technologies in order to supply services of a high quality. As these efforts mature, the research emphasis is shifting from issues surrounding the development of digital library infrastructure and collections to understanding the impact of mulsemedia collections and services to users and related communities. The major consequence is that digital libraries are more and more built as enterprise knowledge ecosystem. In this paper we review the development in the field and points out the challenges of digital library for mulsemedia content management.
Oxygen-Carrying Properties of a Simple Synthetic System (1963)

An iridium compound, chloro-carbonyl-bis(triphenylphosphine)-iridium, in solution, takes up molecular oxygen-one molecule per metal atom-which is subsequently recovered by reducing the pressure. The adduct is photosensitive but otherwise stable at ambient temperatures. It is a monomeric molecular complex and probably contains a peroxo group with both oxygens bonded to the same metal atom.
Investigation of ionization gauges with carbon nanotube (CNT) field-emitter cathodes (2008)

The use of field emitter arrays (FEA) in XHV partial or total pressure measurement so far did not pass the laboratory stage. The reasons are costly manufacturing in comparison to thermionic cathodes and the susceptibility of microtip cathodes to degradation at higher pressures. Today, electron sources based on carbon nanotube (CNT) field emitters are a true alternative to FEAs with microtip cathodes. CNTs with a diameter below 20 nm possess the best field emission properties and are very robust mechanically, which justifies their use in field emission cathodes for vacuum sensors. Starting from basic research to characterize field emission properties, long term stability and stress of CNT field emitters, we present investigations of CNT field emitter electron sources of different provenance in an ionization gauge. We used emission currents of 1 mA and an upper pressure limit of 1 Pa. We compare the results with those of Dong and discuss advantages to a Bayard-Alpert gauge (BAG) with thermionic cathodes. Focus of the presentation is on the investigation of the CNT cathode for applications in ionization gauges.
Structural, magnetic and electronic state characterization of L1<sub>0</sub>-type ordered FeNi alloy extracted from a natural meteorite (2014)

To understand the hard magnetism of L10-type ordered FeNi alloy, we extracted the L10-FeNi phase from a natural meteorite, and evaluated its fundamental solid-state properties: sample composition, magnetic hysteresis, crystal structure and electronic structure. We executed multidirectional analyses using scanning electron microscopy with an electron probe micro-analyzer (SEM-EPMA), a superconducting quantum interference device (SQUID), x-ray diffraction (XRD) and magnetic circular dichroism (MCD). As a result, we found that the composition was Fe: 50.47 ± 1.98 at.%, Ni: 49.60 ± 1.49 at.%, and an obvious superlattice peak is confirmed. The estimated degree of order was 0.608, with lattice constants a = b = 3.582 Å and c = 3.607 Å. The obtained coercivity was more than 500 Oe. MCD analysis using the K absorption edge suggests that the magnetic anisotropy could originate from the orbital magnetic moment of 3d electrons in Fe; this result is consistent with that in a previous report obtained with synthetic L10-FeNi.
Ischemic Preconditioning Regulates Expression of microRNAs and a Predicted Target, MeCP2, in Mouse Cortex (2009)

Preconditioning describes the ischemic stimulus that triggers an endogenous, neuroprotective response that protects the brain during a subsequent severe ischemic injury, a phenomenon known as 'tolerance'. Ischemic tolerance requires new protein synthesis, leads to genomic reprogramming of the brain's response to subsequent ischemia, and is transient. MicroRNAs (miRNAs) regulate posttranscriptional gene expression by exerting direct effects on messenger RNA (mRNA) translation. We examined miRNA expression in mouse cortex in response to preconditioning, ischemic injury, and tolerance. The results of our microarray analysis revealed that miRNA expression is consistently altered within each group, but that preconditioning was the foremost regulator of miRNAs. Our bioinformatic analysis results predicted that preconditioning-regulated miRNAs most prominently target mRNAs that encode transcriptional regulators; methyl-CpG binding protein 2 (MeCP2) was the most prominent target. No studies have linked MeCP2 to preconditioning or tolerance, yet miR-132, which regulates MeCP2 expression, is decreased in preconditioned cortex. Downregulation of miR-132 is consistent with our finding that preconditioning ischemia induces a rapid increase in MeCP2 protein, but not mRNA, in mouse cortex. These studies reveal that ischemic preconditioning regulates expression of miRNAs and their predicted targets in mouse brain cortex, and further suggest that miRNAs and MeCP2 could serve as effectors of ischemic preconditioning-induced tolerance.