gebhart/patrepeval huggingface dataset:
Assessment of the ST segment deviation area as a potential physiological marker of the acute myocardial infarction (2012)

The purpose of this article is to present the assessment of the ST segment deviation area as a feature estimated from electrocardiographic signals to improve the current quantitative measures, which have low correlation with standard measures, such as biomarkers. In total 20 subjects were involved in the study. They were classified into two distinct groups (anterior and inferior) related to the localization of the acute myocardial infarction (AMI). The area of the ST segment was calculated by using customized software developed in Matlab®. From the analysis of this parameter it may be possible to correlate the ST deviation area with the necrosis risk area on myocardial tissue. The correlation between the ST area estimates were compared with Aldrich score, which uses the height of the J point instead of the area. It was calculated the correlation between the ST area, the Aldrich score and biomarkers of myocardial injury in patients. A Spearman correlation coefficient of 0.58 was estimated when comparing Aldrich score and the biomarkers for inferior AMI. The coefficient was 0.99 when correlating the biomarkers to the ST area. Therefore, this feature is a potential physiological marker of inferior AMI. The possibility of estimating the necrosis extent by means of electrocardiographic analysis allows for the reduction of cost and time since there may be no requirement for additional laboratorial exams, consequently improving the treatment efficacy and the prognosis of patients affected by acute myocardial infarction.
Non-Gaussian speckle caused by rough single scale phase screens (1986)

Non-Gaussian speckle can be achieved through the scattering of monochromatic light with a small area of a random phase screen. The random screen is assumed to have a Gaussian probability phase with rms >2 π rad and a lateral autocorrelation Gaussian in shape with scale parameter large compared to the rms phase. Numerical solutions for the average intensity and intensity square are presented and compared with the approximate solutions of Jakeman and McWhirter. 1 Experimental results are shown to agree with these approximations for rms phase <10 rad. A computer simulation of the same experiment for phase objects up to rms phases of 50 rad gives quantitative agreement with the theory at extreme ranges of effective number of illuminated scatterers but consistently overestimates the theory for the peak of each curve in the family of phases simulated.
A novel “chimeric” antibody class in cartilaginous fish: IgM may not be the primordial immunoglobulin (1996)

Using a degenerate oligonucleotide primer specific for immunoglobulin (Ig) constant type 1 (C-1 set) domain genes, products were amplified by the reverse transcriptase-polymerase chain reaction from nurse shark spleen cDNA. The deduced protein sequence of one of these clones reveals a novel Ig class in cartilaginous fish. A complete mRNA could encode a mature protein bearing an amino-terminal variable (V) domain, followed by six C-1 set domains, and ending in a carboxy-terminal tail typical of secreted IgM, IgA, and the new antigen receptor (NAR). The two amino-terminal C domains are orthologous to IgX (or IgR), an Ig heavy (H) chain class in the skate, and the last four domains are homologous to the carboxy-terminal four domains of NAR. We designate this "chimeric" Ig class IgNARC for Ig new antigen receptor from cartilaginous fish. Like NAR, but unlike shark IgM, IgNARC is encoded by very few V and C genes which apparently are not closely linked. The number of bands that hybridize with exon-specific probes varies with genomic DNA from individual sharks, suggestive of different numbers of IgNARC genes in different animals. A protein of approximately 95 kDa, which is likely to be the IgNARC H chain, is immunoprecipitated with both light chain-specific monoclonal antibodies and with antisera generated to a peptide comprising the IgNARC carboxy-terminal tail. We conclude that the arsenal of secreted antigen receptors in cartilaginous fish is greater than previously believed. In addition, our data cast doubt on the dogma that IgM is the primordial Ig isotype.
Amphiphilic peptides with arginines and valines for the delivery of plasmid DNA (2011)

A non-toxic and efficient gene carrier is one requirement for clinical gene therapy. In this study, amphiphilic peptides composed of arginines and valines were synthesized and characterized as plasmid DNA (pDNA) carriers. The peptides have a cationic region containing 1-4 arginines and a hydrophobic region containing 6 valines. The arginine-valine peptides (RV peptides) formed micelles in aqueous solution with a critical micelle concentration (CMC) of 1.35 mg/ml. In gel retardation assay, the RV peptides retarded all pDNA at weight ratios (pDNA:RV peptide) of 1:3 for R1V6, 1:2 for R2V6 and R3V6, and 1:1 for R4V6. A heparin competition assay showed that the R3V6 peptide formed tighter complexes with pDNA than poly-L-lysine (PLL). In vitro transfection assay into HEK293 cells showed that the R1V6 and R2V6 peptides had the highest transfection efficiencies at 1:30 weight ratios (pDNA:RV peptide), while the R3V6 and R4V6 peptides had the highest efficiencies at 1:20 weight ratios. Under optimal conditions, the R3V6 peptide had the highest transfection efficiency of all the RV peptides and PLL. MTT assay showed that the RV peptides did not have any detectable toxicity to cells. Therefore, the RV peptide may be useful for the development of non-toxic gene carriers.
A feature-based approach to an integrated CAD/CAPP system in sheet metal blanking dies (2014)

Computer–aided process planning (CAPP) is considered to be the bridge that links computer–aided design (CAD) and computer–aided manufacturing (CAM). This paper describes a new approach to introduce computer–aided process planning into sheet metal blanking dies industry. The proposed system consists of two modules which are the CAD module and CAPP module. The first module is capable of reading 2D drawings of sheet metal parts provided by AutoCAD software, extracting geometric data from the drawings, building a die geometry that would produce the sheet metal part, and producing solid models of each die component. The second module receives the 3D blanking die components in IGES format and applies an intelligent feature extraction methodology in order to extract their manufacturing characteristics and produce a machining plan for each component. The proposed system is limited to prismatic die components. Finally, a case study is presented for demonstration purposes.
Effects of chemically modified starches in suspensions and lozenges on pH of human dental plaque (1991)

The aim was to evaluate chemically modified starches (CMS) from a cariologic point of view as alternatives to gum arabic in sugar-free lozenges. Two commercial CMS, Purity Gum 40 and Capsul, were selected due to their comparatively low availability to alpha-amylase in vitro. Both gelatinized CMS suspensions and lozenges were tested in vivo by measuring plaque pH. The results showed that suspensions of Purity Gum 40 or Capsul were less available to alpha-amylase in vitro than the soluble starch reference. However, the initial phase of amylolysis was comparatively rapid also with CMS. In spite of the slower rate of hydrolysis, suspensions of the two CMS reduced pH of dental plaque in vivo to the same extent as soluble starch, but somewhat less compared with glucose. Lozenges with Purity Gum 40 also lowered plaque pH, although less than when administered as a precooked suspension. The most prominent pH drop was found with a lozenge containing Purity Gum 40-sucrose-glucose, while tablets with gum arabic-maltitol and pectin-gelatine-Lycasin somewhat increased the pH values. To conclude, it is not recommended to exchange gum arabic for CMS in sugar-free lozenges, since the cariogenic properties of the products are negatively affected.
Enhanced sectionalizing through proper testing of recloser time current curves (2002)

The recent proliferation of software packages containing computer generated time-current curves have helped to free distribution engineers from curve-tracing using transparencies on electric light tables. The new software packages offer speed, flexibility, and ease of operation that enable the distribution engineer to provide enhanced sectionalizing for radial distribution systems. Single phase hydraulic oil circuit reclosers usually comprise a large portion of rural distribution systems and hence, represent a huge percentage of the total sectionalizing scheme. Unfortunately rebuilt oil circuit reclosers do not always exhibit time-current characteristics as depicted on computer generated or manual light tables. This paper summarizes considerations for proper recloser-recloser and recloser-fuse coordination. The paper also presents an approach and method of testing time-current characteristics of single phase hydraulic reclosers with oil or vacuum interrupters. Computer light table software is used to confirm if the "as-tested" time-current characteristics fall within specified tolerance limits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mutations in the <i>Bacillus subtilis glnRA</i> Operon That Cause Nitrogen Source-Dependent Defects in Regulation of TnrA Activity (2002)

The Bacillus subtilis nitrogen transcriptional factor TnrA is inactive in cells grown with excess nitrogen, e.g., glutamine or glutamate plus ammonium, because feedback-inhibited glutamine synthetase (product of glnA) binds to TnrA and blocks its DNA-binding activity. Two conditional mutations that allow TnrA-dependent gene expression in cells grown with glutamate plus ammonium, but not in glutamine-grown cells, were characterized. One mutant contained a mutation in the glnA ribosome binding site, while the other mutant synthesized a truncated GlnR protein that constitutively repressed glnRA expression. The levels of glutamine synthetase were reduced in both mutants. As a result, when these mutants are grown with excess nitrogen in the absence of glutamine, there is insufficient production of the feedback inhibitors necessary to convert glutamine synthetase into its feedback-inhibited form and TnrA-activated genes are expressed at high levels.
Algorithms for characterizing brain metabolites in two-dimensional in vivo MR correlation spectroscopy (2011)

Traditional analyses of in vivo 1D MR spectroscopy of brain metabolites have been limited to the inspection of one-dimensional free induction decay (FID) signals from which only a limited number of metabolites are clearly observable. In this article we introduce a novel set of algorithms to process and characterize two-dimensional in vivo MR correlation spectroscopy (2D COSY) signals. 2D COSY data was collected from phantom solutions of topical metabolites found in the brain, namely glutamine, glutamate, and creatine. A statistical peak-detection and object segmentation algorithm is adapted for 2D COSY signals and applied to phantom solutions containing varied concentrations of glutamine and glutamate. Additionally, quantitative features are derived from peak and object structures, and we show that these measures are correlated with known phantom metabolite concentrations. These results are encouraging for future studies focusing on neurological disorders that induce subtle changes in brain metabolite concentrations and for which accurate quantitation is important.
<b>Kinetics and Relative Rates of the Gallium Bromide-Catalyzed Reactions of Alkyl Bromides with Aromatic Hydrocarbons in 1,2,4-Trichlorobenzene Solution</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics and Relative Rates of the Gallium Bromide-Catalyzed Reactions of Alkyl Bromides with Aromatic Hydrocarbons in 1,2,4-Trichlorobenzene SolutionSang Up. Choi and Herbert C. BrownCite this: J. Am. Chem. Soc. 1963, 85, 17, 2596–2599Publication Date (Print):September 1, 1963Publication History Published online1 May 2002Published inissue 1 September 1963https://pubs.acs.org/doi/10.1021/ja00900a016https://doi.org/10.1021/ja00900a016research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: Comparison with clinical and radiologic examinations (2002)

The fraction of cancer cells immunolabeled for PCNA or Ki67 in preoperative biopsy specimens is helpful to predict neck metastasis.
Electronic power conversion system for an advanced mobile generator set (2002)

The electronic power conversion system and control for an advanced mobile generator set is described. The military generator set uses an internal combustion diesel engine to drive a radial-gap permanent magnet alternator at variable speed. The speed of the engine is determined from a user selectable interface that for a given load and ambient thermal conditions controls the engine to run at its most efficient operating point. It is also possible to control the engine to run where it is most audibly quiet, at its least-polluting operating point, or at its most reliable, stiffest point such that it is less sensitive to load transients. The variable frequency, variable voltage produced by the permanent magnet alternator is diode-rectified to DC voltage, and an inverter is used to produce selectable frequency, controllable AC voltage. The power conversion system also incorporates a bi-directional DC-DC converter that can charge 24 V batteries that are used to start the IC engine and to power auxiliary loads. The bi-directional converter can also draw power from the batteries to help maintain the DC link during severe load transients. The design of this new generator set offers additional flexibility by being lighter, smaller, and more fuel efficient than a conventional fixed-speed gen-set.
Bounds on allowed values of the effective dielectric function of two-component composites at finite frequencies (1982)

The exact solutions for electromagnetic wave propagation in laminar microstructures lead via a waveguide mechanism to values of the effective dielectric function that lie outside the absolute Wiener quasistatic bounds as well as the more restrictive Hashin-Shtrikman limits. The results explain recent refractive-index data of Egan and Hilgeman on pressed-powder composites.
A Calibrated Phase/Frequency Detector for Reference Spur Reduction in Charge-Pump PLLs (2006)

This brief presents a new technique for minimizing reference spurs in a charge-pump phase-locked loop (PLL) while maintaining dead-zone-free operation. The proposed circuitry uses a phase/frequency detector with a variable delay element in its reset path, with the delay length controlled by feedback from the charge-pump. Simulations have been performed with several PLLs to compare the proposed circuitry with previously reported techniques. The proposed approach shows improvements over previously reported techniques of 12 and 16 dB in the two closest reference spurs
ZigBee suitability for Wireless Sensor Networks in Logistic Telemetry Applications (2006)

There has been a quick development in the wireless network area during the last decade. Mostly these days the focus in the wireless area is on very high speed and long range applications. This thesis describes how ZigBee is suitable for wireless sensor networks in logistic telemetry applications for global managing and monitoring of goods. ZigBee has been developed by the organization named as ‘ZigBee Alliance’ as a new wireless standard for the wireless solutions based upon the IEEE 802.15.4 Standard [2]. ZigBee is a new technology as compared to the other wireless technologies such as Bluetooth, but it has certain characteristics such as low cost, low power, support for mesh networking e.t.c which makes its chances to be more successful than others. The other aim of this thesis is to examine different issues related to ZigBee to see its fitness for logistic telemetry applications like multi-hop routing issues, routing strategies and design requirements. ZigBee is relatively new wireless technology, so there are great deals of promises associated with it. In this thesis, a comparison between ZigBee and Bluetooth technologies will also be made.
Human-in-the-loop experimental research for detect and avoid (2015)

This paper provides an overview of a Detect and Avoid (DAA) concept developed by the National Aeronautics and Space Administration (NASA) for integration of Unmanned Aircraft Systems (UAS) into the National Airspace System (NAS), and provides results from human-in-the-loop experiments performed to investigate interoperability and acceptability issues associated with use of the concept with these vehicles and operations. The series of experiments was designed to incrementally assess critical elements of the new concept and the enabling technologies that will be required.
Injuries to the Neonatal Larynx from Long-Term Endotracheal Tube Intubation and Suggested Tube Modification for Prevention (1975)

Since the early 1960's nasotracheal tubes have been used for neonates with primary respiratory diseases which necessitated positive pressure ventilation. This therapy may be required for extended periods of weeks to months meaning prolonged trauma to the neonatal larynx. The initial injury and long-term effects of the endotracheal tube in this age group have not been adequately investigated. The acute findings can be arytenoid and posterior commissure ulcerations and, in some cases, cartilage erosion. Long-term follow-up in these children to age 3.5 years showed a persistent arytenoid defect with chronic hoarseness. The consideration of a change in the structure of the endotracheal tube is suggested as a possible means of avoiding these injuries.
Targeted deletion of <i>Wwox</i> reveals a tumor suppressor function (2007)

The WW domain-containing oxidoreductase (WWOX) spans the second most common fragile site of the human genome, FRA16D, located at 16q23, and its expression is altered in several types of human cancer. We have previously shown that restoration of WWOX expression in cancer cells suppresses tumorigenicity. To investigate WWOX tumor suppressor function in vivo, we generated mice carrying a targeted deletion of the Wwox gene and monitored incidence of tumor formation. Osteosarcomas in juvenile Wwox(-/-) and lung papillary carcinoma in adult Wwox(+/-) mice occurred spontaneously. In addition, Wwox(+/-) mice develop significantly more ethyl nitrosourea-induced lung tumors and lymphomas in comparison to wild-type littermate mice. Intriguingly, these tumors still express Wwox protein, suggesting haploinsuffiency of WWOX itself is cancer predisposing. These results indicate that WWOX is a bona fide tumor suppressor.
Discovery of Regulatory Elements by a Computational Method for Phylogenetic Footprinting (2002)

Phylogenetic footprinting is a method for the discovery of regulatory elements in a set of orthologous regulatory regions from multiple species. It does so by identifying the best conserved motifs in those orthologous regions. We describe a computer algorithm designed specifically for this purpose, making use of the phylogenetic relationships among the sequences under study to make more accurate predictions. The program is guaranteed to report all sets of motifs with the lowest parsimony scores, calculated with respect to the phylogenetic tree relating the input species. We report the results of this algorithm on several data sets of interest. A large number of known functional binding sites are identified by our method, but we also find several highly conserved motifs for which no function is yet known.
Thiocyanation of N-arylsulfonyl-, N-aroyl-, and N-[(N-arylsulfonyl)benzimidoyl]-1,4-benzoquinone imines (2009)

Reactions of thiocyanate ion with N-aroyl-, N-arylsulfonyl-, and N-(N-arylsulfonylbenzimidoyl)-1,4-benzoquinone imines follow the 1,4-addition pattern, and the adducts undergo intramolecular cyclization to give the corresponding N-substituted 5-amino-1,3-benzoxathiol-2-ones as final products.
Cognitive Radio Technology For Flexible Spectrum Sharing (2006)

Recent study by FCC Spectrum-Policy Task Force (SPTF) found that while the available spectrum becomes increasingly scarce, the assigned spectrum is significantly underutilized. Cognitive radio (CR) technology refers to a new type of radio hat uses real-time interaction with its environment to determine transmitter parameters such as frequency, power, and modulation. This paper presents a preliminary survey of CR with the goal of quantifying spectral occupancy and thereby gaining some insight into its feasibility. Two case studies were investigated: ultra-wide bandwidth technology as a transmission technique suitable for implementing a cognitive radio system was discussed, and a comparable measurement of TV spectrum band in an urban environment is also presented.
Efficient regular path query evaluation using path indexes (2016)

We demonstrate the use of localized path indexes in generating efficient execution plans for regular path queries. This study is motivated by both the practicality of this class of queries and by the current dearth of scalable solutions for their evaluation. Our proposed solution leverages widely available relational database technology and is often orders of magnitude faster than currently known approaches. We aim in this hands-on demonstration to both highlight the promise of our approach and to stimulate further discussion and study of engineering solutions for this practical yet challenging class of graph queries.
EFFECTS OF SOIL TEMPERATURE ON THE PHYTOTOXICITY OF TRIFLURALIN TO WILD OATS (1980)

Experiments were conducted in the field and in controlled environment chambers at Beaverlodge, Alberta to determine the influence of soil temperature on the phytotoxicity of trifluralin (α,α,α-trifluoro-2,6-dinitro-N, N-dipropyl-p-toluidine) to wild oats (Avena fatua L.). In the field trifluralin reduced wild oat emergence the most in early May when soil temperatures were lowest. As soil temperatures increased in May, the effectiveness of trifluralin in reducing wild oat emergence declined. In controlled environment studies, the effectiveness of trifluralin in reducing wild oat shoot growth was greatest at 4 °C. At 7.5 °C, the effectiveness of trifluralin in reducing wild oat shoot growth declined. However, at both 10 and 20 °C, small increases in trifluralin phytotoxicity occurred. Exposure of wild oat shoots to trifluralin vapors at 7.5 and 20 °C indicated decreased shoot growth of wild oats at 7.5 °C but increased volatilization of trifluralin at 20 °C. Thus, the lack of any major differences in the effectiveness of trifluralin in reducing wild oat shoot growth at temperatures from 7.5 to 20 °C may be due to the counteraction of these two phenomena.