gebhart/patrepeval huggingface dataset:
SKLB-287, a novel oral multikinase inhibitor of EGFR and VEGFR2, exhibits potent antitumor activity in LoVo colorectal tumor model (2014)

Colorectal cancer (CRC) is the third common cancer and most of the chemotherapies of CRC currently used often suffer limited efficacy and large side effects. Targeted small-molecule by anti-tumor drugs are thought a promising strategy for improving the efficacy and reducing the side effects. In this investigation, we report a novel multikinase inhibitor, termed SKLB-287, which was discovered by us recently. SKLB-287 could efficiently inhibit the activation of endothelial growth factor receptor (EGFR) and vascular endothelial growth factor receptor 2 (VEGFR2). It displayed very good anti-proliferative activity against LoVo CRC cells and considerable antiangiogenic potency in transgenic zebrafish embryos. Oral administration of SKLB-287 resulted in dose-dependent suppression of tumor growth in LoVo xenograft mouse model. Immunohistochemistry was adopted to examine the in vivo anti-tumor mechanism of action of SKLB-287.
Effect of five cysteine‐containing compounds on three lipogenic enzymes in Balb/cA mice consuming a high saturated fat diet (2004)

The in vivo effects of N-acetyl cysteine (NAC), S-allyl cysteine, S-ethyl cysteine (SEC), S-methyl cysteine (SMC), and S-propyl cysteine (SPC) against hyperlipidemia development and oxidation stress in Balb/cA mice consuming a high saturated fat diet were examined. The influence of these agents on plasma levels of glucose, insulin, uric acid, TG, cholesterol, and the activity of three lipogenic enzymes--glucose-6-phosphate dehydrogenase, malic enzyme, and FA synthase--was determined. All mice consumed the coconut oil-basd, high saturated fat diet, water, and cysteine or one of the five cysteine-containing compounds for 4 wk. The diet with 18% saturated fat significantly elevated the activity of three lipogenic enzymes and significantly increased TG and cholesterol biosynthesis in plasma and liver (P < 0.05). When compared with the water and cysteine groups, the treatments from five cysteine-containing agents significantly reduced high saturated fat diet-increased malic enzyme and FA synthase activities, and significantly lowered TG levels in plasma and liver (P< 0.05); however, only NAC, SAC, and SMC treatments significantly reduced cholesterol levels in plasma and liver (P < 0.05). The five cysteine-containing agents significantly restored high saturated fat diet-decreased glutathione peroxidase (GPX) activity in liver (P< 0.05); however, only SMC and SPC significantly restored GPX activity in heart and kidney (P< 0.05). These agents also significantly improved high saturated fat diet-related hyperglycemia, hyperuricemia, and oxidation stress (P < 0.05). These data support the hypothesis that these compounds are potential multiply-protective agents for hyperlipidemia prevention or therapy.
<i>Vegfb</i> gene knockout mice display reduced pathology and synovial angiogenesis in both antigen‐induced and collagen‐induced models of arthritis (2003)

The reduction in inflammation-associated synovial angiogenesis in Vegfb(-/-) mice implicates VEGF-B in pathologic vascular remodeling in inflammatory arthritis. VEGF-B may be an attractive target in the design of anti-angiogenic therapies for rheumatoid arthritis.
Open Ephys: an open-source, plugin-based platform for multichannel electrophysiology (2017)

The Open Ephys GUI is the first widely used application for multichannel electrophysiology that leverages a plugin-based workflow. We hope that it will lower the barrier to entry for electrophysiologists who wish to incorporate real-time feedback into their research.
Charge Trapping Properties of 3C- and 4H-SiC MOS Capacitors With Nitrided Gate Oxides (2009)

Silicon-carbide-based MOS capacitors were formed on either 3C (epitaxial on Si) or 4H substrates and using SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gate dielectrics both with and without interfacial nitrogen. The charge trapping properties of these structures were examined after exposure to ionizing radiation. In all cases interfacial nitrogen results in improved trap density and increased oxide charge trapping. For equivalent nitrogen content, 3C-based devices exhibit more charge trapping than the 4H-based equivalents.
5′ proximal sequences of a soybean ribulose-1, 5-bisphosphate carboxylase small subunit gene direct light and phytochrome controlled transcription (1987)

Two closely related ribulose-1,5-bisphosphate carboxylase small subunit (SSU) genes, SRS1 and SRS4, are transcribed at high levels in soybean plants in response to light. Transgenic petunia plants containing 5' sequences from SRS1 or SRS4 fused to the polypeptide encoding region of a neomycin phosphotransferase (NPTII) gene exhibit selectable kanamycin resistance. Deletion of three ATG codons from the region preceding the normal NPTII translation start site has little effect on the levels of kanamycin resistance in transformed plants. Run-on transcription assays in isolated nuclei demonstrate that transcription of the SRS1/NPTII chimera and the native petunia SSU11A gene subfamily is light regulated and under phytochrome control in leaves of transgenic plants. In young expanding leaves of fully light grown plants, transcription of these genes is markedly reduced within minutes of far-red treatment, while ribosomal DNA and actin gene transcription remains unchanged. This is analogous to the transcriptional response we observed for SRS1 and SRS4 in soybean seedlings. These data suggest (1) that transcription of SSU genes in both soybean and petunia require the continued presence or synthesis of phytochrome in the Pfr form and (2) that 5' sequences are sufficient to direct the phytochrome controlled transcriptional response of the SRS1 gene. In fully expanded mature leaves we found the transcription rates of the native SSU11A gene subfamily, the chimeric SRS1/NPTII gene, the rDNA genes, and several other control genes to be reduced markedly after far-red treatment or after extended periods of darkness. The contrast between results in young and mature leaves is discussed.
Integrated Approach to Drilling Fluid Optimisation for Efficient Shale Instability Management (1998)

Abstract An integrated approach to drilling fluid design and optimisation, in terms of mud weight and chemistry, for efficient shale instability management has been developed in a collaborative project. The key drilling fluid-shale interaction mechanisms included in the state-of-the-art design criteria are mud pressure penetration, chemical potential and swelling-hydrational stress. Fundamental concepts, processes, models and a range of novel test equipment and procedures for laboratory simulation of the mechanisms were developed. Shale and drilling fluid properties required for the models were determined using a range of analytical and laboratory techniques. The laboratory simulation results for various mud types were used in the refinement and verification of the models. The verified models, which have been integrated in a wellbore stability analysis software, were used to conduct analyses to demonstrate the effects of shale and drilling fluid properties on time-dependent wellbore (in)stability. They highlight the conditions in which the mechanisms are critical and need to be incorporated in the analysis. In addition, the test equipment also provide effective methods of screening drilling fluids (type and formulation) for their capacity to provide the required effective mud support with time for a given shale. The understanding of the mechanisms of drilling fluid-shale interaction and the development of the capacity to model them enabled the development of drilling fluid design charts. These charts, together with a shale property database and property correlations, provide a pragmatic and effective approach for designing optimal drilling fluids to manage shale instability efficiently. The wellbore stability analysis software and drilling fluid design charts have been used in both drilling fluid program recommendation and back-analysis of field experience. A full-scale field trial of the technology is currently being undertaken in collaboration with an operating company.
Handheld Guides in Inspection Tasks: Augmented Reality versus Picture (2017)

Inspection tasks focus on observation of the environment and are required in many industrial domains. Inspectors usually execute these tasks by using a guide such as a paper manual, and directly observing the environment. The effort required to match the information in a guide with the information in an environment and the constant gaze shifts required between the two can severely lower the work efficiency of inspector in performing his/her tasks. Augmented reality (AR) allows the information in a guide to be overlaid directly on an environment. This can decrease the amount of effort required for information matching, thus increasing work efficiency. AR guides on head-mounted displays (HMDs) have been shown to increase efficiency. Handheld AR (HAR) is not as efficient as HMD-AR in terms of manipulability, but is more practical and features better information input and sharing capabilities. In this study, we compared two handheld guides: an AR interface that shows 3D registered annotations, that is, annotations having a fixed 3D position in the AR environment, and a non-AR picture interface that displays non-registered annotations on static images. We focused on inspection tasks that involve high information density and require the user to move, as well as to perform several viewpoint alignments. The results of our comparative evaluation showed that use of the AR interface resulted in lower task completion times, fewer errors, fewer gaze shifts, and a lower subjective workload. We are the first to present findings of a comparative study of an HAR and a picture interface when used in tasks that require the user to move and execute viewpoint alignments, focusing only on direct observation. Our findings can be useful for AR practitioners and psychology researchers.
An analytical comparison to heuristic and meta-heuristic solution methods for Quadratic Assignment Problem (2010)

Quadratic Assignment Problem (QAP) is a well known problem in the facility location and layout. It belongs to NP-Complete class, so that the exact solution methods consume much computational time. There are some heuristic and meta-heuristic methods presented for this problem in the literature. In this paper we applied 3-Opt, greedy 3-Opt, 3-Opt, greedy 3-Opt and VNZ as the heuristic methods and TS (Tabu Search), SA (Simulated Annealing) and PSO (Particle Swarm Optimization) as the meta-heuristic methods for the QAP. This research dedicated to compare their gap with optimum solution for the selected data set from the QAPLIB. Results show that 3-Opt as a heuristic method and TS which belongs to meta-heuristic methods have a better solution in less computational time. Finally some more analysis has been illustrated in the paper.
Combining hypertext and structured documents in Grif (1993)

This paper presents the experience gained in developing and using the hypertext functions of the Grif systeml. Grif is a structured document editor based on the generic structure concept: each document is represented in the system by it~logical structure which is an instance of a generic structure. This notion of logical structure encompasses both hierarchical structures (as is usual in structured documents) and non-hierarchical links (as is usual in hypertext).
A Simplified Wittig Synthesis Using Solid/Liquid Transfer Processes IV - Synthesis of symmetrical and asymmetrical mono-and di-olefins from terephtalic aldehyde (1983)

Abstract Dialdehydes can give rise, through a Wittig reaction carried out in an anhydrous homogeneous medium, to the corresponding diolefins (1–3). The high reactivity of the ylides generated under these experimental conditions precludes mono olefination which therefore requires the previous protection of one of the aldehyde functions (1–3).
Computerised mass spectrometry (1980)

A consideration of data acquisition from mass spectrometers covers the description of the system as dedicated or resource-sharing, the specification of an analogue-to-digital conversion (ADC) system (dynamic range and sampling rate) and alternative discontinuously sampling ADC systems. Peak recognition routines must be able to distinguish a number of peak types from the train of incoming digital data. Full control of the mass spectrometer can be effected by operation in the stepping mode. Time-to-mass conversion procedures must be particularly closely defined when accurate mass data is required. Procedures for data reduction and data clean-up are particularly important in the processing of repetitive scan data acquired during the analysis of complex mixtures. A number of data-system-based procedures are available for the final interpretation of mass spectral data-library search, pattern recognition and interpretation of fragmentation. The calculation of elemental compositions from accurate mass data and the calculation of quantitative data are also considered.
Extraction of Topographic Map Elements with SAR Stereoscopic Measurement (2011)

SAR is one of very important topographic mapping sensors in the area where there is much cloud and brume using SAR images, because of its advantages compared to optical sensor, such as all-day, all-weather, penetrating a certain depth of ground and so on. SAR interferometry can be used to extract high precise elevation. SAR stereoscopic observation is impossible when observing the same area from different position. The basis of stereoscopic observation is ideal stereoscopic image pair. In this paper, the method generating ideal stereoscopic image pair with SAR stereo pair base on DEM from SAR interferometry is proposed. The vertical parallax between two images of the pair is eliminated, and the horizontal parallax is reconstructed by image simulation according to the DEM. Then topographic map elements, such as contour lines, ground features and so on, can be extracted under digital stereoscopic environment with ideal pair. Mapping experiment with high resolution airborne SAR images proved the method is feasible.
Correcting over-exposure in photographs (2010)

This paper introduces a method to correct over-exposure in an existing photograph by recovering the color and lightness separately. First, the dynamic range of well exposed region is slightly compressed to make room for the recovered lightness of the over-exposed region. Then the lightness is recovered based on an over-exposure likelihood. The color of each pixel is corrected via neighborhood propagation and also based on the confidence of the original color. Previous methods make use of ratios between different color channels to recover the over-exposed ones, and thus can not handle regions where all three channels are over-exposed. In contrast, our method does not have this limitation. Our method is fully automatic and requires only one single input photo. We also provide users with the flexibility to control the amount of over-exposure correction. Experiment results demonstrate the effectiveness of the proposed method in correcting over-exposure.
Effect of piroxicam gel for pain control and inflammation in Nd:YAG 1064‐nm laser hair removal (2006)

This study showed that piroxicam gel provided adequate pain relief after Nd:YAG 1064 nm laser hair removal in women volunteers. Piroxicam gel was associated with lesser inflammatory side effects when compared to placebo because of its anti-inflammatory effect after the procedure.
Three dimensional arrays of cobalt nanocrystals: Fabrication and magnetic properties (2002)

Cobalt nanocrystal three dimensional (3D) arrays were fabricated by deposition of a ferrofluid on a highly oriented pyrolitic graphite substrate and by applying a magnetic field parallel to the substrate during the deposition process. Depending on the strength of the magnetic field, regular stripes of cobalt nanocrystals are obtained. The influence of the deposition process parameters was investigated. The magnetic properties of these 3D arrays are discussed in terms of orientation of the easy axes and ferromagnetic domain formation.
Development and industrialization of liquid crystal materials (2005)

The development and industrialization of some liquid crystal materials: the ester with strong positive dielectric anisotropy for TN LCD, the tolan with large birefringence, the alkenyl with large k33/k11 elastic ratio and the azine with large birefringence and high N-I transition temperature for STN LCD, and the fluorinated liquid crystals of fused ring systems for TFT LCD, are reviewed. The work on new fluorinated naphthalene with negative dielectric anisotropy for VA LCD is introduced.
Wave-front correction of femtosecond terawatt lasers by deformable mirrors (1998)

Wave-front correction and focal spot improvement of femtosecond laser beams have been achieved, for the first time to our knowledge, with a deformable mirror with an on-line single-shot three-wave lateral shearing interferometer diagnostic. Wave-front distortions of a 100-fs laser that are due to third-order nonlinear effects have been compensated for. This technique, which permits correction in a straightforward process that requires no feedback loop, is also used on a 10-TW Ti:sapphire-Nd:phosphate glass laser in the subpicosecond regime. We also demonstrate that having a focal spot close to the diffraction limit does not constitute a good criterion for the quality of the laser in terms of peak intensity.
NOVEL MECHANISMS OF BREQUINAR SODIUM IMMUNOSUPPRESSION ON T CELL ACTIVATION (1994)

Brequinar sodium (BQR) is a novel immunosuppressive agent that acts by inhibiting the activity of dihydroorotate dehydrogenase, the fourth enzyme in the de novo pyrimidine biosynthetic pathway. The activity of BQR as an immunosuppressive agent is believed to be inhibition of antigen-induced lymphocyte proliferation through inhibition of DNA and RNA synthesis. BQR, therefore, has a different mechanism of action than cyclosporine and may potentiate the immunosuppressive effects of cyclosporine. In this study, we determined the effect of BQR on peripheral blood mononuclear cell (PBMC) activation in a series of in vitro culture systems. In these studies, BQR inhibited PHA-stimulated activation in a dose-dependent fashion beginning at 10(-6) M. The immunosuppressive effect of BQR was similar in magnitude to cyclosporine. Proliferation assays suggested an additive immunosuppression by the combination of BQR and cyclosporine. Similar inhibition of CD2-stimulated or CD3-stimulated activation of PBMC was found. The mechanisms of action of BQR were complex. BQR inhibited interleukin 2 protein production in response to mitogen stimulation. Cell surface interleukin 2 receptor expression was inhibited by BQR. BQR inhibited cell cycle progression, preventing progression from G0/G1 into S and G2 + M phases. BQR had no effect on induction of transcripts for the interleukin 2 receptor, but markedly inhibited the production of transcripts for interleukin 2. Thus, our studies indicate that BQR exerts a potent immunosuppression on mitogen-induced PBMC activation through multiple mechanisms. Consequently, BQR may be an effective agent for immunosuppression in organ transplantation or inflammatory diseases.
Spectroscopic Applications of Laser-Induced Plasmas (1992)

Abstract Recent spectroscopic applications of laser-induced plasmas are reviewed. Virtually all substances are susceptible to breakdown when illuminated by a sufficiently intense laser beam. In a plasma, matter breaks apart into atoms, ions, and electrons, producing a visible flash and an audible popping sound due to the acoustical shock wave generated by the sudden, high-velocity expansion of matter outward from the plasma volume. Useful information about the elemental composition of the target material can be obtained from analysis of the emissions emanating from the plasma volume. Among the applications currently being tested in many laboratories are studies of particulate as well as gaseous pollutants in air, toxic substances present in flowing wastewater, elemental content of alloys, composition of iron ores and coal samples, contaminants on the surface of microcircuit boards, and the contents of fluid inclusions in geological samples. The beauty of laser-induced plasma spectroscopy is sample accessibility.
A QoS Control Method Based on SLA (2013)

This study suggests a service level agreement (SLA)-based resource management method that flexibly changes resource management functions depending on mobile handset state and converged network state, applies the changed resource management functions, and thus secures optimal performance based on an administrator’s policy for operating a converged network. To effectively manage wireless resources, this study considers the SLA service model, and in order to continuously ensure quality of service (QoS) agreed to in the SLA, this study provides a maintenance function as well as the QoS level, connecting service level specifications to SLA-based QoS support.
Efficient parallel algorithms on distance-hereditary graphs (2002)

We present efficient parallel algorithms for finding a minimum weighted connected dominating set, a minimum weighted Steiner tree for a distance-hereditary graph which take O(log n) time using O(n+m) processors on a CRCW PRAM, where n and m are the number of vertices and edges of a given graph, respectively. We also find a maximum weighted clique of a distance-hereditary graph in O(log/sup 2/ n) time using O(n+m) processors on a CREW PRAM.
To Invest in Technology or Not? New Tools for Making the Decision (1992)

A new species, Synergus mongolicus Pujade-Villar & Wang n. sp., is described from galls collected on twigs of Quercus mongolica. The morphological characters useful for differentiating the new species are also discussed. Three inquilines species are recorded from China for the first time: Saphonecrus shirakashii, Synergus belizinellus and S. symbioticus. Saphonecrus tianmushanus is considered a n. syn. of S. shirakashii based on comparison of the types. Saphonecrus taiwanensis Pujade-Villar new name is proposed for Saphonecrus lithocarpii Schwéger & Melika, 2015 by homonymy with S. lithocarpi Pujade-Villar, Guo, Wang & Chen, 2015 and finally Saphonecrus chinensis Tang & Schwéger, 2015 is considered a n. syn. of S. lithocarpi Pujade-Villar, Guo, Wang & Chen, 2015.
Functional Properties of Extruded Rice Flours (2003)

ABSTRACT The functional properties of a long‐grain and a short‐grain rice flour extruded at 70 to 120°C and 22% moisture are reported. The bulk densities essentially stayed unchanged. Both water absorption and water solubility indices increased with an increase in extrusion temperature. The fat absorption indices decreased only at 55°C. The cold‐paste viscosities progressively increased, whereas the peak, breakdown, setback, and final viscosities decreased with an increase in extrusion temperature. A substitution of 25% of unextruded or 70°C extruded long‐grain rice flour into a wheat flour‐based fried snack decreased its fat absorption by 35% to 50% without affecting the overall texture.