gebhart/patrepeval huggingface dataset:
MAP Kinases Mediate UVB-induced Phosphorylation of Histone H3 at Serine 28 (2001)

Histone H3 phosphorylation is related closely to chromatin remodeling and chromosome condensation. H3 phosphorylation at serine 28 is coupled with mitotic chromosome condensation in diverse mammalian cell lines. However, the pathway that mediates phosphorylation of H3 at serine 28 is unknown. In the present study, ERK1, ERK2, or p38 kinase strongly phosphorylated H3 at serine 28 in vitro. JNK1 or JNK2 was able also to phosphorylate H3 at serine 28 in vitro but to a lesser degree. UVB irradiation markedly induced phosphorylation of H3 at serine 28 in JB6 Cl 41 cells. PD 98059, a MEK1 inhibitor, and SB 202190, a p38 kinase inhibitor, efficiently repressed UVB-induced H3 phosphorylation at serine 28. Expression of dominant negative mutant (DNM) ERK2 in JB6 Cl 41 cells totally blocked UVB-induced phosphorylation of H3 at serine 28. Additionally, DNM p38 kinase or DNM JNK1 partially blocked UVB-induced H3 phosphorylation at serine 28. Furthermore, UVB-induced H3 phosphorylation at serine 28 was inhibited in Jnk1(-/-) cells but not in Jnk2(-/-) cells. These results suggest that UVB-induced H3 phosphorylation at serine 28 may be mediated by mitogen-activated protein kinases.
A 32nm SRAM reliability macro for recovery free evaluation of NBTI and PBTI (2012)

A scalable test structure for recovery free evaluation of the impact of NBTI and PBTI on read/write operation in a SRAM macro has been developed. A novel non-invasive methodology keeps the stress interrupts for measurements within a few microseconds, preventing unwanted BTI recovery, while providing a parallel stress-measure capability on 32kb sub-arrays. Measurement results in a 32nm high-κ/metal-gate silicon-on-insulator process show that proposed schemes provides 35mV better accuracy in read V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MIN</sub> and 10X accuracy in BFR.
The uniqueome: a mappability resource for short-tag sequencing (2010)

Files, scripts and supplementary data are available from http://grimmond.imb.uq.edu.au/uniqueome/; the ISAS uniqueome aligner is freely available from http://www.imagenix.com/.
Nodes Localization through Data Fusion in Sensor Network (2005)

The location of nodes in sensor network is an important problem with application in resource allocation, location sensitive browsing, and emergency communications. A key problem in sensor network location is the creation of a method that is robust to measurement quantization and measurement noise and also has a reasonable implementation cost. The RSS and TDoA are the popular distance measurement methods, but can be easy affected by noise and not independent. This paper explores a covariance intersection (CI) that fuses together location estimations obtained from power propagation loss measurements and propagation time to obtain higher accuracy location estimate. The performances of Kalman filter type estimators are severely affected by the ignored cross covariance. CI algorithm provides a mechanism to fuse two or more random variables with unknown correlation such that the computed covariance of the new estimate is consistent; therefore CI method is quite suitable for sensor network application. In simulation result shows that position estimates are correct within small ranging distance with few initial master nodes of the system.
Optically Reconfigurable Photonic Devices (2016)

<span style='white-space:pre-line'>Data set to support the published paper: Optically reconfigurable metasurfaces and photonic devices based on phase change materials Wang, Q., Rogers, E., Gholipour, B., Wang, C. H., Yuan, G. H., Teng, J. H. & Zheludev, N. I. 1 Jan 2016 In : Nature Photonics. 10, p. 60-65 </span>
Background correction in factor analysis of dynamic scintigraphic studies: necessity and implementation (1990)

In factor analysis, structures are separated on the basis of their temporal behaviour, even if there is a partial overlap. Usually, the temporal behaviour of the system under study cannot be sampled in its true form due to a total overlap by the background. In the ROI (region of interest) method, background subtraction is used as a means to correct the problem. In factor analysis, this problem has been ignored for a long time. We prove that the factor analysis method gives incorrect results when there is a total overlap of a structure. By assuming a local homogeneity of the overlapping structure, we can greatly improve the solution found. Compared with the classical ROI method, our method is operator independent and organ specific.
Carbon Syntheses with Malonic and Related Acids. I (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon Syntheses with Malonic and Related Acids. IArthur Michael and John RossCite this: J. Am. Chem. Soc. 1933, 55, 9, 3684–3695Publication Date (Print):September 1, 1933Publication History Published online1 May 2002Published inissue 1 September 1933https://doi.org/10.1021/ja01336a034Request reuse permissions Article Views187Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Clinical potential of autologous epithelial suspension (2003)

Consideration must be given to salvage all viable elements when treating burn injuries. However, when the extent of injury is such that healing using conservative treatment is prolonged, surgical intervention will be necessary to improve the quality of scar outcome. The tailoring of the surgical intervention to the injury is outlined in this article. Specifically, epidermal reconstruction using cellular autologous epithelial suspension in combination with traditional skin grafting techniques and other tissue engineering technologies is described.
Precise Timing for Multiband OFDM in a UWB System (2006)

Precise positioning is one attractive application of ultra wideband (UWB) systems. Its enormous bandwidth has generated high expectation on the spatial resolution that it could achieve. However, synchronization in the presence of dense multipath is challenging, since the first arrival is not necessarily the strongest one due to channel fading. It is unclear how high a spatial resolution can be realized in practical implementation, and how reliable it will be. We in this paper address practical synchronization algorithms for multiband OFDM UWB transmission, and analyze the performance of a maximum likelihood (ML) joint timing/channel estimation algorithm. We show that the probability of mis-timing in single band OFDM has only diversity order one. Most timing errors lie closely around the right timing, as we show that the probability of timing error equal to or greater than Delta having diversity order of min(Delta, L), where L the number of channel taps. We reveal the benefit of frequency hopping across multiple subbands that enables an N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</sub> -fold diversity increase in timing performance, where N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</sub> is the number of subbands used
Texture Effect on Magnetic Properties by Alloying Specific Elements in Non-grain Oriented Silicon Steels (2005)

The effect of texture on magnetic properties by adding specific elements of tin, antimony and boron was investigated. Texture factor was defined as the ratio of the sum of cube and Goss textures to γ fibre. Tin and antimony showed larger effect in enhancing grain size than boron for both hot rolled and cold rolled bands. Texture factor increased with an increase in grain size; that is, grain size effect on texture factor appeared larger for the addition of tin and antimony than for boron. Both tin and antimony showed large volume fractions of cube and Goss textures but low volume fraction of γ fibre compared to boron. The effect of texture factor on core loss was larger for tin and antimony added steels than for boron added steel. Magnetic flux density increased proportionally with the texture factor and the effect of texture factor on magnetic flux density was also greater in tin and antimony added steels than in boron steel.
ChemInform Abstract: AMIDINES AND RELATED COMPOUNDS PART 6, STUDIES ON STRUCTURE‐ACTIVITY RELATIONSHIPS OF ANTIHYPERTENSIVE AND ANTISECRETORY AGENTS RELATED TO CLONIDINE (1975)

Abstract Aus den Isothioharnstoffäthern (I) und Aminoacetaldehydacetal (II) entstehen die Kondensate (III), die mit HCl zu (IV) und (V) cyclisiert werden.
Corrosive effect of carbon-fibre reinforced plastic on stainless-steel screws during implantation into man (1983)

The corrosion of stainless-steel screws used to fix carbon-fibre reinforced plastic (CFRP) plates to human fractures was compared with the corrosion on similar screws used to fix stainless-steel AO plates. Corrosive changes were noted in both sets of screws with similar frequency and severity; however, the stainless-steel plates were 'in situ' almost twice as long as the CFRP ones, showing that the corrosive changes occurred more rapidly on screws in contact with CFRP. Nevertheless, over the implantation time necessary for bone healing, corrosion was very mild and there is no clinical contra-indication to the use of stainless-steel and CFRP together in this particular application.
Strength properties of separators in alkaline solutions (2002)

Cellulose-based separators have been used in alkaline battery systems for many years. In particular, Ag-Zn systems have used cellophane and fiber-reinforced regenerated cellulose manufactured via the viscose process as the main separator. There has been a reported decrease in the shelf-life of Ag-Zn batteries. One of the believed causes is degradation of the cellulosic separator by the alkaline solution (40% KOH) that is used as the electrolyte. Battery separator nonwovens that were coated with regenerated cellulose via the viscose process were subjected to storage in 40% potassium hydroxide (KOH) over a two month period. Samples were periodically checked for wet MD tensile strength. The test showed that among the nonwovens, the polyamide retained about 93% of its initial tensile strength whereas polyvinyl alcohol and cellulosic nonwovens retained only 55% and 35%, respectively. Adding a viscose coating to the nonwovens improved tensile strength retention by 20-25% for the polyvinyl alcohol and cellulosic materials. The viscose-coated polyamide retained more than 98% of its initial tensile strength.
Mouse models for preeclampsia: disruption of redox-regulated signaling (2009)

The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-O-methyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia-like symptoms (high blood pressure, albuminurea and preterm birth) resulting from extensive vasculo-endothelial pathology, primarily at the utero-fetal interface where maternal cardiac output is dramatically increased during pregnancy. Comt converts estradiol to 2-methoxyestradiol 2 (2ME2) which counters angiogenesis by depleting hypoxia inducible factor-1 alpha (HIF-1 alpha) at late pregnancy. We propose that in wild type (Comt++) pregnant mice, 2ME2 destabilizes HIF-1 alpha by inhibiting mitochondrial superoxide dismutase (MnSOD). Thus, 2ME2 acts as a pro-oxidant, disrupting redox-regulated signaling which blocks angiogenesis in wild type (WT) animals in physiological pregnancy. Further, we suggest that a lack of this inhibition under normoxic conditions in mutant animals (Comt-/-) stabilises HIF-1 alpha by inactivating prolyl hydroxlases (PHD). We predict that a lack of inhibition of MnSOD, leading to persistent accumulation of HIF-1 alpha, would trigger inflammatory infiltration and endothelial damage in mutant animals. Critical tests of this hypothesis would be to recreate preeclampsia symptoms by inducing oxidative stress in WT animals or to ameliorate by treating mutant mice with Mn-SOD-catalase mimetics or activators of PHD.
<title>New seven-sample symmetrical phase-shifting algorithm</title> (1993)

A new seven-sample algorithm has been developed which is particularly useful for phase evaluation in systems with non-sinusoidal periodic waveforms. The algorithm performs well in systems with significant amounts of second, third, fourth, and sixth harmonic content and in the presence of phase shift errors. The algorithm is characterized by an equi-spaced symmetrical sampling pattern in which the end samples are one full period apart. Principal features of the algorithm in terms of the Fourier theory of phase-shifting are presented. Performance of the seven-sample algorithm is outlined and compared with several conventional algorithms.
Modulation of Release of Proinflammatory Bacterial Compounds by Antibacterials: Potential Impact on Course of Inflammation and Outcome in Sepsis and Meningitis (2002)

Several bacterial components (endotoxin, teichoic and lipoteichoic acids, peptidoglycan, DNA, and others) can induce or enhance inflammation and may be directly toxic for eukaryotic cells. Bactericidal antibiotics which inhibit bacterial protein synthesis release smaller quantities of proinflammatory/toxic bacterial compounds than B-lactams and other cell wall-active drugs. Among the B-lactams, compounds binding to penicillin-binding protein 2 (PBP-2) release smaller amounts of bacterial substances than antibacterials inhibiting PBP-3. Generally, high antibiotic concentrations (more than 10 times the MIC) induce the release of fewer bacterial proinflammatory/toxic compounds than concentrations close to the MIC. In several in vitro and in vivo systems, bacteria treated with protein synthesis inhibitors or B-lactams inhibiting PBP-2 induce less inflammation than bacteria treated with PBP-3-active B-lactams. In mouse models of Escherichia coli peritonitis sepsis and of Streptococcus pneumoniae meningitis, lower release of proinflammatory bacterial compounds was associated with reduced mortality. In conclusion, sufficient evidence for the validity of the concept of modulating the release of proinflammatory bacterial compounds by antibacterials has been accumulated in vitro and in animal experiments to justify clinical trials in sepsis and meningitis. A properly conducted study addressing the potential benefit of bacterial protein synthesis inhibitors versus B-lactam antibiotics will require both strict selection and inclusion of a large number of patients. The benefit of this approach should be greatest in patients with a high bacterial load.
Frequency transient measurements in power systems (1959)

A RECENTLY developed frequency transient magnitude measuring system measures, accurately and conveniently with digital read out, the magnitude of frequency transients in power systems. It is not affected by the variables which normally produce inaccuracies in other frequency transient measuring systems.
Ancient Dunes along the Coast of the Japan Sea (1967)

Sand beds which mainly consist of massive, consolidated and well-sorted sand are observed along the coast of the Japan Sea and are thought to be Pleistocene dunes. The writers call these dunes the "Ancient Dunes" in contrast with "Recent Dunes" of the Holocene epoch. The Ancient Dunes can be classified into two groups: the older "Ancient Dunes I" and the other "Ancient Dunes II" according to the different ages of formation.The Ancient Dunes I consists of grey, massive and consolidated medium sand, the lower part of which is occasionally aqueous, and is overlying on the middle terrace deposits almost conformably, although partly unconformably. The dunes of this group are found all along the coast of the Japan Sea from North Kyûshû to Aomori Prefecture, the northernmost of Honshû.The Ancient Dunes II consists of pale yollow fine sand with crepe-like texture, which is a characteristic feature of loessy sand. The dunes of this group are distributed at Yasuoka in Yamaguchi Prefecture and south of it while, along the northern coasts they are not found. There is brown weathered clay or volcanic ash overlying the Ancient Dunes I, which may be the equivalent to them in age.The stratigraphic relation between the sand beds of the Ancient Dunes and the terrace deposits or volcanic ash deposits suggests that the Ancient Dunes I and II are correlated to the Riss-Würm interglacial and the Würm glacial stages respectively. They are thought to have been formed the marine regression in glacial ages.
Foreword: Public Interest Lawyering and Law School Pedagogy (2003)

University of San Diego School of Law Dean Daniel B. Rodriguez highlights the need for law schools to promote the development of public interest lawyering and the particular challenges faced by law schools in encouraging the development of the requisite curriculum.
NAD<sup>+</sup>/NADH-Sensitive Quantum Dots: Applications To Probe NAD<sup>+</sup>-Dependent Enzymes and To Sense the RDX Explosive (2008)

Phenyl boronic acid-functionalized CdSe/ZnS quantum dots (QDs) were synthesized. The modified particles bind nicotinamide adenine dinucleotide (NAD(+)) or 1,4-dihydronicotinamide adenine dinucleotide (NADH). The NAD(+)-functionalized QDs are effectively quenched by an electron transfer process, while the NADH-modified QDs are inefficiently quenched by the reduced cofactor. These properties enable the implementation of the QDs for the fluorescence analysis of ethanol in the presence of alcohol dehydrogenase. The NADH-functionalized QDs were used for the optical analysis of the 1,3,5-trinitrotriazine, RDX explosive, with a detection limit that corresponded to 1 x 10(-10) M. We demonstrate cooperative optical and catalytic functions of the core-shell components of the QDs in the analysis of RDX.
Overexpression and purification of non-glycosylated recombinant endo-β-<i>N</i>-acetylglucosaminidase F<sub>3</sub> (1995)

The gene for endo-beta-N-acetylglucosaminidase F3 was cloned into the high-expression vector pMAL c-2, and expressed in Escherichia coli as a fusion protein. A key step in the purification employed Poros II (HS) chromatography, which greatly facilitated isolation of the enzyme from crude intracellular lysates. The unfused enzyme was recovered following digestion with Factor Xa and was isolated in a homogeneous form. The enzyme is non-glycosylated and fully active, and is a very useful analytical tool for investigating the structure of asparagine-linked glycans, especially those with core-substituted alpha 1,6 fucosyl residues.
8000-V 1000-A gate turn-off thyristor with low on-state voltage and low switching loss (1990)

An 8 kV, 1 kA gate turn-off thyristor (GTO) that has been designed with a combination of a p-i-n structure and a ringed-anode short structure is discussed. The GTO has been fabricated using a diffusion and epitaxial buffer process. As a consequence, low on-state voltage and low switching loss have been achieved, solving the two major problems in high-voltage GTOs. The device's structure, the p-i-n base process, and the electrical characteristics of the GTO are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pulsed laser action in LiYF&lt;inf&gt;4&lt;/inf&gt;:Er&lt;sup&gt;3+&lt;/sup&gt;, Ho&lt;sup&gt;3+&lt;/sup&gt;at 77°K (1969)

Pulsed laser action at 77°K has been demonstrated in LiYF <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</inf> :Er <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> , Ho <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> with an emission wavelength of 2.066 μ. The laser transition is the <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I_{7} \rightarrow</tex> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> I <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</inf> in trivalent holmium, and there is evidence of energy transfer from erbium to holmium. The fluorescent lifetime is approximately 20 ms, and the pulsed threshold is 40 joules.
Renal Biopsy in Gout (1961)

Occasional dilated tub ules with eosinophil casts Atrophy and dilatation with eosino phil casts Atrophy only, marked focally Normal Slight diffuse increase, prob ably normal for juxta medullary cortex Normal Very fine collagen between tubules, probably normal Diffuse slight increase of collagen, more marked focally. No inflammatory cells Slight focal periglomerular and perivascular fibrosis Slight cellular and fine col l?ge nous increase. No inflammatory cells Very slight diffuse increase with fine collagen Slight diffuse cellular and collagenous increase. No inflammatory cells Moderate increase. No in flammatory cells
Evaluation of three simple direct or indirect carbonyl detection methods for characterization of oxidative modifications of proteins (2012)

Among disruptions induced by oxidative stress, modifications of proteins, particularly irreversible carbonylation, are associated with the development of several diseases, including cardiovascular diseases, neurodegenerative diseases, and cancer. Carbonylation of proteins can occur directly or indirectly through the adduction of lipid oxidation products. In this study, three classical and easy-to-perform techniques to detect direct or indirect carbonylation of proteins were compared. A model protein apomyoglobin and a complex mixture of rat liver cytosolic proteins were exposed to cumene hydroperoxide oxidation or adduction to the lipid peroxidation product 4-hydroxynonenal in order to test direct or indirect carbonylation, respectively. The technique using a specific anti-4-hydroxynonenal-histidine adduct antibody was effective to detect in vitro modification of model apomyoglobin and cytosolic proteins by 4-hydroxynonenal but not by direct carbonylation which was achieved by techniques using biotin-coupled hydrazide or dinitrophenylhydrazine derivatization of carbonyls. Sequential use of these methods enabled the detection of both direct and indirect carbonyl modification in proteins, although constitutively biotinylated proteins were detected by biotin-hydrazide. Although rather classical and efficient, methods for carbonyl detection on proteins in oxidative stress studies may be biased by some artifactual detections and complicated by proteins multimerizations. The use of more and more specific available antibodies is recommended to complete detection of lipid peroxidation product adducts on proteins.