gebhart/patrepeval huggingface dataset:
Endogenous Rhythms in Plants (1956)

Crop loss due to soil salinization is an increasing threat to agriculture worldwide. This review provides an overview of cellular and physiological mechanisms in plant responses to salt. We place cellular responses in a time- and tissue-dependent context ...Read More
The Use of Transient Expression Systems for the Rapid Production of Virus-like Particles in Plants (2013)

Advances in transient expression technologies have allowed the production of milligram quantities of proteins within a matter of days using only small amounts (tens of grams) of plant tissue. Among the proteins that have been produced using this approach are the structural proteins of viruses which are capable of forming virus-like particles (VLPs). As such particulate structures are potent stimulators of the immune system, they are excellent vaccine candidates both in their own right and as carriers of additional immunogenic sequences. VLPs of varying complexity derived from a variety of animal viruses have been successfully transiently expressed in plants and their immunological properties assessed. Generally, the plant-produced VLPs were found to have the expected antigenicity and immunogenicity. In several cases, including an M2e-based influenza vaccine candidate, the plant-expressed VLPs have been shown to be capable of stimulating protective immunity. These findings raise the prospect that low-cost plant-produced vaccines could be developed for both veterinary and human use.
A delivery scheduling system by the distributed cooperative multiple agents (2002)

In this paper, we propose a practical method for solving the delivery scheduling problem with multiple agents and discuss its implementation. The method is based on the distributed cooperative problem solving. In the delivery scheduling system, the covered region is partitioned into multiple subregions and each subregion is assigned a subproblem solving agent which solves the problem of scheduling of drivers and trucks in the subregion. Integrating those subproblem solving agents, an integration-and-evaluation agent solves the total problem. By employing the distributed cooperative problem solving framework for the delivery scheduling problem, we achieved an easy incorporation of various evaluation parameters in the process of scheduling, efficient use and management of scheduling knowledge of various levels, and reduction of computer processing by division of the problem into subproblems.
Resistant Starches Types 2 and 4 Have Differential Effects on the Composition of the Fecal Microbiota in Human Subjects (2010)

Our results demonstrate that RS2 and RS4 show functional differences in their effect on human fecal microbiota composition, indicating that the chemical structure of RS determines its accessibility by groups of colonic bacteria. The findings imply that specific bacterial populations could be selectively targeted by well designed functional carbohydrates, but the inter-subject variations in the response to RS indicates that such strategies might benefit from more personalized approaches.
Roles of CUB domain‐containing protein 1 signaling in cancer invasion and metastasis (2011)

Tumor metastasis is a complex multistep process by which cells from the primary tumor invade tissues, move through the vasculature, settle at distant sites and eventually grow to form secondary tumors. Altered tyrosine phosphorylation signals in cancer cells contribute to a number of aberrant characteristics involved in tumor invasion and metastasis. CUB domain-containing protein 1 (CDCP1) is a substrate of Src family kinases and has been shown to regulate anoikis resistance, migration and matrix degradation during tumor invasion and metastasis in a tyrosine phosphorylation-dependent manner. Knockdown of CDCP1 blocks tumor metastasis or peritoneal dissemination in vivo, without significantly affecting cell proliferation. Moreover, expression levels of CDCP1 are of prognostic value in several cancers. Here, we summarize the studies on CDCP1, focusing on structure and signal transduction, to gain insight into its role in cancer progression. Understanding the signaling pathways regulated by CDCP1 could help establish novel therapeutic strategies against the progression of cancer.
The Comedies of Shakespeare. The Histories and Poems of Shakespeare. The Tragedies of Shakespeare (1951)

Journal Article W. J. Craig, ed., The Works of Shakespeare Get access The Comedies of Shakespeare. The Histories and Poems of Shakespeare. The Tragedies of Shakespeare. London, New York, Toronto: Oxford University Press, 1951. Pp. [xxxix] — 1128; [v] — 1214; [v] — 1313. 3 vols. $45.00. J. G. M. J. G. M. Search for other works by this author on: Oxford Academic Google Scholar Shakespeare Quarterly, Volume 2, Issue 4, Autumn 1951, Page 367, https://doi.org/10.2307/2866263 Published: 01 October 1951
Building Domain-Specific Languages for Model-Driven Development (2007)

Today, the popularity of dynamic languages such as Python and Ruby is growing beyond their use as scripting languages. In fact, Sun, Microsoft, and other companies are supporting some dynamic languages on their development platforms. Developers increasingly find that dynamic languages' features help them enhance their productivity, while common misconceptions about them, such as poor performance and reliability, are disappearing. Embedding domain-specific language in a dynamic language rather than constructing a compiler or interpreter can improve program readability and development time.
Molecular Cloning, Genomic Organization, Promoter Activity, and Tissue-Specific Expression of the Mouse Ryudocan Gene (1997)

Ryudocan, a ubiquitous heparan sulfate proteoglycan, is a member of the syndecan family of cell surface proteoglycans. The full-length cDNA encoding the murine ryudocan core protein has now been cloned and sequenced. The deduced primary structure of mouse ryudocan, including the three glycosaminoglycan attachment sites in the extracellular domain as well as the transmembrane and cytoplasmic regions, is highly similar to those of the rat, human, and chicken proteins. Northern analysis detected a 2.7-kb transcript in all mouse tissues examined, with the highest concentrations apparent in liver, kidney, and lung. The mouse ryudocan gene was shown to span approximately 19.7 kb of genomic DNA and to contain five exons, with an intron-exon organization identical to that of the human gene. The promoter region of the mouse gene contains various cis-acting elements, including a TATA-like box and a GC box as well as potential binding sites for the transcription factors NF-IL6, MyoD, GATA, C/EBP, AP-2, NF-kappaB, AP-1, and Sp1. Transient transfection experiments with a construct containing the 690 bp upstream of the transcription start site fused to a luciferase reporter gene showed functional promoter activity. Deletion analysis suggested that the proximal promoter region including the TATA-like box, the GC box, and other Sp1 binding sites was required for full transcriptional activity. These findings will be useful for the study of ryudocan gene regulation and the generation of mice with targeted disruption of the gene.
200 MHz video compression macrocells using low-swing differential logic (2002)

Improving the performance of fully dedicated macrocells is key to realizing HDTV-resolution video de/compression LSIs operating at more than 100 MHz, having reasonable power consumption and chip size small enough for consumer applications. Existing circuit techniques are either not sufficiently fast or are area consuming. However, these problems are overcome by using low-swing differential logic to realise such macrocells.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Q-DRAM: QoE-Based Dynamic Rate Adaptation Mechanism for Multicast in Wireless Networks (2009)

The deployment of real-time and multimedia applications over wireless LAN has gained a growing interest in this last decade. These applications, e.g. video streaming, require tight guarantee on quality of service (QoS). Also, they use multicast communication in order to reduce the bandwidth consumption. However, in WLAN, multicast packets are sent with the basic rate (lowest rate); which results in capacity wasting because of longer channel occupancy. Moreover the lack of feedback mechanism makes it difficult to deal with reliability or service quality. In this paper, we propose to rely on the WLAN multi-rate capability, in order to transmit multicast packets with higher and dynamic rate than the basic rate. Unlike other existing protocols that use a static-threshold to decide when to change transmission rate, we propose a novel dynamic rate-adaptation mechanism based on quality of experience (QoE), namely Q-DRAM. According to the clients' feedback on QoE, we adapt the multicast rate: (i) when users had bad QoE we reduce the multicast transmission rate; (ii) when users had good QoE, we increase the multicast transmission rate. Simulation results show that Q-DRAM increases the wireless channel utilization and maximizes users' QoE, compared to existing solutions as well as to the IEEE 802.11 standard.
Intracellular labeling of T‐cells with superparamagnetic contrast agents (1993)

Isolated rat T-cells have been labeled intracellularly, using endocytosis uptake of two superparamagnetic contrast agents, AquaMag100 and BMS180549, which are both iron-oxide particles coated with dextran. No deterioration of cell proliferation response to mitogen stimulation was observed after labeling with either superparamagnetic contrast agent. AquaMag100 particles show aggregation and co-precipitation in culture media for T-cells. BMS180549 particles not only produce no observable aggregation or co-precipitation, but also have a higher efficiency for labeling T-cells than AquaMag100. The efficiency of cell labeling was determined by measuring the decrease in the spin-spin relaxation time of the water proton in cell samples containing 1 x 10(7) labeled T-cells/milliliter of 2% w/w gelatin. After optimization of the labeling procedures, a shortening of the spin-spin relaxation time by a factor of approximately 7 to 10 has been demonstrated. Under the present experimental conditions, the up-regulation of low density lipoprotein receptor does not increase the labeling efficiency by endocytosis. Our results suggest that intracellular labeling of specific cell types can be achieved with good efficiency and the labeled cells can be detected by magnetic resonance imaging in rat testicles in vivo.
Activity-centred Search in Email. (2008)

We consider activity-centered tasks in email, including the novel task of predicting future involvement of persons from an enterprise in an ongoing activity represented by a folder, and a novel task where we identify email messages that are related to a to-do item. We also evaluate the task of email tagging to folders, where multiple choice is allowed, and an inverse task, of finding messages relevant to a folder associated with an ongoing project. Empirical evaluation using real world email data, applying a graph based link analysis method and a vector-space model, shows potential utility to facilitate activity management in email. 1
MEETING FUTURE EMISSION STANDARDS WITH LEADED FUELS (1971)

THE ARTICLE DISCUSSES FEDERAL EXHAUST EMISSION REQUIREMENTS FOR 1975 AND 1976, AND THE DISADVANTAGES THAT ARISE FROM USING THE SUGGESTED UNLEADED FUELS. THE PROPOSAL OF THE ETHYL CORPORATION IS TO RETAIN THE ADVANTAGES OF HIGH-COMPRESSION ENGINES AND LEADED FUELS BY DEVISING A FUEL METERING SYSTEM THAT PERMITS OPERATION ON A VERY LEAN MIXTURE. A THREE-VENTURI CARBURETTOR HAS BEEN DEVELOPED THAT IS CLAIMED TO GIVE FUEL ATOMIZATION AND AIR MIXING; WHEN USED IN CONJUNCTION WITH INSULATED EXHAUST PARTS AND STAINLESS STEEL REACTOR MANIFOLDS, IT VERY NEARLY MEETS THE FEDERAL REQUIREMENTS. DEVELOPMENT WORK IS IN PROGRESS FOR FURTHER REDUCTION IN EXHAUST GAS EMISSION USING THIS LEAN- REACTOR SYSTEM.
Liquid chromatography‐mass spectrometry method for quantification of caspofungin in clinical plasma samples (2007)

Caspofungin [(CASPO) MK-0991] is the first broad-spectrum anti-fungal agent of the echinocandin class approved for clinical use. Measurement of CASPO levels in blood might help monitor therapy in patients who are critically ill, in particular, if high-dose regimens or combinations of CASPO with other anti-fungals are used. The objective of this study was to develop a fast method for the measurement of CASPO levels in clinical blood samples using liquid chromatography coupled to a triple-quadrupole mass spectrometer. Stock solutions were prepared in plasma to avoid CASPO adsorption to glass and plastic surfaces during processing. CASPO and the internal standard (IS) were extracted from 100 microl of plasma using acetonitrile protein precipitation. The supernatant was diluted and directly injected into an analytical column (C8; 2.1 x 30 mm). The total run time was 15 min. CASPO was ionized by electrospray in the positive mode. CASPO and IS [M + 2H]2+ parent ions (m/z 547.3 and 547.8, respectively) and specific product ions (m/z 137.1 and 62.2, respectively) were used for the ion transitions. No carry over or cross-talk was observed on the column. The mean method recovery was 90 +/- 3%. Neither blood from different individuals (n = 6) nor the presence of concomitant drugs (n = 33) in plasma samples interfered with CASPO quantification. Quantification over time of the CASPO levels in plasma and whole blood was investigated at different pre-analysis storage conditions. The calibration curve included the clinically relevant CASPO concentration range from 0.04 to 20 microg/ml. Mean intra- and inter-day accuracy was 96.1 +/- 2.2% and 102.5 +/- 2.4%, respectively. Mean intra- and inter-day precision was 7.9 +/- 3.2% and 6.3 +/- 1.8%, respectively. This simple and robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method may easily be implemented for monitoring CASPO therapy.
Formation of fine magnetite particles by oxidation of aqueous suspensions of ferrous hydroxide (1990)

Abstract Fine magnetite particles were prepared by oxidation of aqueous ferrous hydroxide suspensions in a bubble column equipped with an internal concentric draft tube. The oxidation reaction rate could be expressed apparently as zero‐order with respect to the concentration of total ferrous species and first‐order with respect to the concentration of dissolved oxygen. The final particle size generally decreased with increasing reaction rate. The geometric Standard deviation of size‐distribution ranged from 1.20 to 1.35 under the present experimental conditions, and increased with an increase in reaction rate.
Effects of Deuterium-Plasma Treatment at the a-Si:H/a-SiN:H Interface on the Field-Effect Mobility of a Thin-Film Transistor (2015)

The effects of deuterium-plasma treatment on the electrical characteristics of an inverted staggered thin-film transistor (TFT) were investigated. The deuterium-plasma treatment was applied at the a-Si:H/a-SiN:H interface, and its effects were compared with those for a hydrogen-plasma treatment under the same plasma-treatment conditions. The thin-film transistor without plasmatreatment of the a-SiN:H exhibited a field effect mobility of 0.09 cm2/V??s while the TFT with hydrogen-plasma treatment for 20 min had a mobility of 0.38 cm2/V??s, and the TFT with using deuterium-plasma treatment for 20 min had a higher mobility of 0.54 cm2/V??s. The surface roughness of a-SiN:H was found to be closely connected with the field-effect mobility, and deuterium plasma treatment at the a-Si:H/a-SiN:H interface was found to be an effective way to increase the field effect mobility of an a-Si:H TFT.
Ribosome-Inactivating and Related Proteins (2015)

Ribosome-inactivating proteins (RIPs) are toxins that act as N-glycosidases (EC 3.2.2.22). They are mainly produced by plants and classified as type 1 RIPs and type 2 RIPs. There are also RIPs and RIP related proteins that cannot be grouped into the classical type 1 and type 2 RIPs because of their different sizes, structures or functions. In addition, there is still not a uniform nomenclature or classification existing for RIPs. In this review, we give the current status of all known plant RIPs and we make a suggestion about how to unify those RIPs and RIP related proteins that cannot be classified as type 1 or type 2 RIPs.
Concrete early-age strength monitoring using embedded piezoelectric transducers (2006)

At early ages of concrete structures, strength monitoring is important to determine the structures' readiness for service. Piezoelectric-based strength monitoring methods provide an innovative experimental approach to conduct concrete strength monitoring at early ages. In this paper, piezoelectric transducers in the form of 'smart aggregates' are embedded into the concrete specimen during casting. Piezoceramic materials can be used as actuators to generate high frequency vibrating waves, which propagate within concrete structures; meanwhile, they can also be used as sensors to detect the waves. The smart aggregate is a one cubic inch, pre-cast concrete block with a wired, embedded PZT (lead zirconate titanate, a type of piezoceramic) patch. The strength development of concrete structures is monitored by observing the development of harmonic response amplitude from the embedded piezoelectric sensor at early ages. From experimental results, the amplitude of the harmonic response decreases with increasing concrete strength. The concrete strength increases at a fast rate during the first few days and at a decreasing rate after the first week. Concordantly, the amplitude of the harmonic response from the piezoelectric sensor drops rapidly for the first week and continues to drop slowly as hydration proceeds, matching the development of the concrete strength at early ages. Concrete is heterogeneous and anisotropic, which makes it difficult to analyze mathematically. Fuzzy logic has the advantage of conducting analysis without requiring a mathematical model. In this paper, a fuzzy logic system is trained to correlate the harmonic amplitude with the concrete strength based on the experimental data. The experimental results show that the concrete strength estimated by the trained fuzzy correlation system matches the experimental strength data. The proposed piezoelectric-based monitoring method has the potential to be applied to strength monitoring of concrete structures at early ages.
Triaxial magnetic field gradient system for microcoil magnetic resonance imaging (2000)

There is a great advantage in signal to noise ratio (S/N) that can be obtained in nuclear magnetic resonance (NMR) experiments on very small samples (having spatial dimensions ∼100 μm or less) if one employs NMR “micro” receiver coils, “microcoils,” which are of similarly small dimensions. The gains in S/N could enable magnetic resonance imaging (MRI) microscopy with spatial resolution of ∼1–2 μm, much better than currently available. Such MRI microscopy however requires very strong (&gt;10 T/m), rapidly switchable triaxial magnetic field gradients. Here, we report the design and construction of such a triaxial gradient system, producing gradients substantially greater than 15 T/m in all three directions, x, y, and z (and as high as 50 T/m for the x direction). The gradients are switchable within time ∼10 μs and adequately uniform (within 5% over a volume of [600μm3] for microcoil MRI of small samples.
The Association of Imidazole with the Ions of Zinc and Cupric Copper<sup>1a,b,c</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Association of Imidazole with the Ions of Zinc and Cupric Copper1a,b,cJohn T. Edsall, Gary Felsenfeld, DeWitt S. Goodman, and Frank R. N. GurdCite this: J. Am. Chem. Soc. 1954, 76, 11, 3054–3061Publication Date (Print):June 1, 1954Publication History Published online1 May 2002Published inissue 1 June 1954https://pubs.acs.org/doi/10.1021/ja01640a068https://doi.org/10.1021/ja01640a068research-articleACS PublicationsRequest reuse permissionsArticle Views1645Altmetric-Citations148LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cardiovascular and Electrodermal Response Patterns in Heart Rate Reactive Individuals During Psychological Stress (1980)

ABSTRACT The goal of this research was to examine the cardiovascular and electrodermal response patterns of heart rate reactive and nonreactive individuals to psychological stress. Sixty males were tested while resting, listening to tones, identifying tone patterns, and performing mental arithmetic. Dependent variables were blood pressure, heart rate (HR), and skin conductance responses. Based on the change in HR from baseline to the first minute of mental arithmetic, two extreme reactivity groups of 15 subjects each were formed. Results indicated that HR reactive subjects had higher systolic blood pressure and HR than nonreactives. Reactives showed greater HR lability during all the tasks and a phasic acceleration to tones, while nonreactives showed a deceleration. Finally, comparisons of skin conductance responses indicated that subjects who were nonreactive when measuring HR were more reactive when measuring skin conductance. The HR reactivity seen in these subjects has been linked to predisposition to psychosomatic illness, and the current findings are discussed in that light.
The Development of Transgenic Crops to Improve Human Health by Advanced Utilization of Seed Storage Proteins (2011)

Seed storage proteins are a major component of mature seeds. They are utilized as protein sources in foods. We designed seed storage proteins containing bioactive peptides based on their three-dimensional structures. Furthermore, to create crops with enhanced food qualities, we developed transgenic crops producing seed storage proteins with bioactive peptides. This strategy promises to prevent lifestyle-related diseases by simple daily food consumption. In this review, we discuss a strategy to develop transgenic crops to improve human health by advanced utilization of seed storage proteins.
Formation, growth and ageing of clathrate hydrate crystals in a porous medium (2006)

An experimental study was performed to visually observe the driving force dependence of hydrate growth in a porous medium filled with either liquid water and dissolved CO2 or liquid water and gaseous CO2. The given system subcooling, ΔT sub, i.e. the deficiency of the system temperature from the triple CO2−hydrate−water equilibrium temperature under a given pressure, ranged from 1.7 K to 7.3 K. The fine dendrites initially formed at ΔT sub = 7.3 K changed quickly into particulate crystals. For ΔT sub = 1.7 K, faceted hydrate crystals grew and the subsequent morphological change was hardly identified for an eight-day observation period. These results indicate that the physical bonding between hydrate crystals and skeletal materials becomes stronger with decreasing driving force, suggesting that the fluid dynamic and mechanical properties of hydrate-bearing sediments vary depending on the hydrate crystal growth process.