gebhart/patrepeval huggingface dataset:
Capturing Dense Environmental Range Information with a Panning, Scanning Laser Rangefinder (1998)

Abstract|We use a laser rangender with a scanning mir-ror on a panning platform to acquire range data in a local environment (range &lt; 15m). In this paper, we discuss the hardware components, the software, show several examples of the range data, and discuss problematic issues such as material properties. We conclude with our future plans for improving the data and integrating it into our research pro-gram.
Characterization of a Mutant Calcineurin Aα Gene Expressed by EL4 Lymphoma Cells (1995)

The calmodulin-stimulated phosphatase calcineurin plays a critical role in calcium-dependent T-lymphocyte activation pathways. Here, we report the identification of a missense mutation in the calcineurin A alpha gene expressed by EL4 T-lymphoma cells. This mutation changes an evolutionarily conserved aspartic acid to asparagine within the autoinhibitory domain of the calcineurin A alpha protein. A comparison of wild-type and mutant autoinhibitory peptides indicates that this amino acid substitution greatly reduces inhibition of calcineurin phosphatase activity. Additional peptide inhibition studies support a pseudosubstrate model of autoinhibitory function, in which the conserved aspartic acid residue may serve as a molecular mimic of either phosphoserine or phosphothreonine. Expression of the mutant calcineurin appears to affect cellular signal transduction pathways, as EL4 cells can be activated by suboptimal concentrations of calcium ionophore in the presence of phorbol esters. Moreover, this phenotype can be transferred to Jurkat T cells by transfection of the mutated calcineurin gene. These findings implicate a conserved aspartic acid in the mechanism of calcineurin autoinhibition and suggest that mutation of this residue is associated with aberrant calcium-dependent signaling in vivo.
Out-of-core compression for gigantic polygon meshes (2003)

Polygonal models acquired with emerging 3D scanning technology or from large scale CAD applications easily reach sizes of several gigabytes and do not fit in the address space of common 32-bit desktop PCs. In this paper we propose an out-of-core mesh compression technique that converts such gigantic meshes into a streamable, highly compressed representation. During decompression only a small portion of the mesh needs to be kept in memory at any time. As full connectivity information is available along the decompression boundaries, this provides seamless mesh access for incremental in-core processing on gigantic meshes. Decompression speeds are CPU-limited and exceed one million vertices and two million triangles per second on a 1.8 GHz Athlon processor.A novel external memory data structure provides our compression engine with transparent access to arbitrary large meshes. This out-of-core mesh was designed to accommodate the access pattern of our region-growing based compressor, which - in return - performs mesh queries as seldom and as local as possible by remembering previous queries as long as needed and by adapting its traversal slightly. The achieved compression rates are state-of-the-art.
Real-Time Quantitative Analysis of Telomerase Activity in Breast Tumor Specimens Using a Highly Specific and Sensitive Fluorescent-Based Assay (2002)

Telomerase activity has been associated with almost 90% of malignant human cancers from a variety of tissue sources, making it one of the most prominent molecular cancer markers known to date. As such, telomerase has become a very attractive diagnostic and therapeutic target. The advent of the telomeric repeat amplification protocol (TRAP) has allowed for the semiquantitative detection of telomerase from limiting sample amounts. Both the standard TRAP assay and a real-time assay using Amplifluor technology with primers designed specifically for telomerase activity amplification were used to quantitatively assess telomerase activity in primary tumors and tumor-derived cell lines. We have adapted the recently developed TRAPeze XL telomerase detection kit (Intergen, Gaithersburg, MD) for use with real-time polymerase chain reaction for more accurate quantification and high-throughput capabilities. In doing so, the reliability, assay time, and accuracy of quantitation have all been dramatically improved. A comparison of the quantitative analysis for the standard TRAP assay versus the real-time assay using 19 breast tumors revealed telomerase quantitation and standardization using the real-time assay was superior to the standard assay. Our data suggest that this assay will be useful for clinical and research studies involving detection of telomerase activity as it relates to cancer diagnosis.
Functional magnetic resonance imaging studies of emotional processing in normal and depressed patients: effects of venlafaxine. (1997)

While preliminary, these results demonstrate the power of using fMRI to study emotional processes in normal and depressed subjects and to examine mechanisms of action of antidepressant drugs.
DIGITAL ROAD MAPPING WITH GPS AND GIS (1991)

Describes research and development that integrates GPS, GIS, and electronic charting technologies to map road and street networks
Storage and Control of Optical Photons Using Rydberg Polaritons (2013)

We use a microwave field to control the quantum state of optical photons stored in a cold atomic cloud. The photons are stored in highly excited collective states (Rydberg polaritons) enabling both fast qubit rotations and control of photon-photon interactions. Through the collective read-out of these pseudospin rotations it is shown that the microwave field modifies the long-range interactions between polaritons. This technique provides a powerful interface between the microwave and optical domains, with applications in quantum simulations of spin liquids, quantum metrology and quantum networks.
Photochlorination in a tubular reactor (1966)

Abstract A method of describing the behavior of a single‐phase, photochemical reaction in a tubular flow reactor is given. A simplified form of the equations is applied to experimental data for the chlorination of propane. The results indicate that the reaction rate is second order in chlorine concentration and first order in light intensity at the wall. Independent experimental actinometer measurements permit the determination of absolute values of the kinetic constants. Such data are rarely available for photochemical reactions. Filter solutions flowing through a jacket around the reactor is shown to be a practical method for studying the effects of light intensity, as well as for cooling the reactor. The optical efficiency of the reactor lamp system was 11%.
Analysis, design, and experimental results of a 1-kW ZVS-FB-PWM converter employing magamp secondary-side control (1998)

The design and breadboard implementation of a constant-frequency, zero-voltage-switched, full-bridge pulsewidth modulation converter delivering a 12-V-at-1-kW output from a 350-450-VDC input bus is described. The zero-voltage switching characteristic is maintained over a wide operating range by utilizing the transformer magnetizing inductance as an energy storage element. Output voltage regulation is accomplished entirely on the secondary side through magamp control, thus simplifying the methods used for maintaining control and isolation.
Spectral Clustering and Feature Selection for Microarray Data (2009)

Microarray datasets comprise a large number of gene expression values and a relatively small number of samples. Feature selection algorithms are very useful in these situations in order to find a compact subset of informative features. We propose a redundancy control method for algorithms in the recently proposed SPEC family of spectral-based feature selection algorithms. This method is applied to find relevant genes in order to cluster samples corresponding to three kinds of cancer: lung, breast and colon.
Dynamics and Directional Sensitivity of Neck Muscle Spindle Responses to Head Rotation (1987)

Y. S. Chan, J. Kasper, and V. J. Wilson, “Dynamics and Directional Sensitivity of Neck Muscle Spindle Responses to Head Rotation.” Taiwan was incorrectly added to the present address of Y. S. Chan on page 1728. The correct address is Dept. of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong.
265 PLASMA MICRORNAS AS BIOMARKERS FOR PLATELET INHIBITION (2013)

Introduction MicroRNAs (miRNAs) are small non-coding RNAs that are also detectable in the blood. Circulating levels of miRNAs have been measured in various epidemiological studies, but the effects of medication are unclear. To address these uncertainties, we aimed to (1) compare the levels of miRNAs in different sample types, (2) assess how miRNAs change in response to platelet inhibition and (3) correlate their plasma levels with existing markers of platelet activation. Methods MiRNAs were assessed by real-time polymerase chain reaction in the following cohorts: Study population Mean age, y Male, % 9 volunteers participating in a dose-escalation study <40 100% 33 patients with symptomatic carotid stenosis 72.1 ± 1.9 82% 129 patients post myocardial infarction 59.7 ± 10.4 81% Result (1) Profiling for 377 miRNAs was performed in platelets, platelet microparticles, platelet-rich plasma, platelet-poor plasma, and serum. Platelet-rich plasma showed markedly higher levels of miRNAs than serum and platelet-poor plasma. Few abundant platelet miRNAs, such as miR-24, miR-197, miR-191, and miR-223, were also increased in serum compared with platelet-poor plasma. (2) Antiplatelet therapy significantly reduced miRNA levels. Using custom-made quantitative real-time polymerase chain reaction plates, 92 miRNAs were assessed in a dose-escalation study in healthy volunteers at 4 different time points: at baseline without therapy, at 1 week with 10 mg prasugrel, at 2 weeks with 10 mg prasugrel plus 75 mg aspirin, and at 3 weeks with 10 mg prasugrel plus 300 mg aspirin. Findings in healthy volunteers were confirmed by individual TaqMan quantitative real-time polymerase chain reaction assays. Validation was performed in an independent cohort of patients with symptomatic atherosclerosis, who received low-dose aspirin at baseline. Plasma levels of platelet miRNAs, such as miR-223, miR-191, and others, that is, miR-126 and miR-150, decreased on further platelet inhibition. (3) In a cohort of patients on dual anti-platelet therapy 30 days post myocardial infarction, plasma levels of most platelet miRNAs were positively correlated to the vasodilator-stimulated phosphoprotein phosphorylation (VASP) assay. Levels of miR-126 were also significantly associated with results from the VerifyNow P2Y 12 aggregation assay. No association was observed with optical aggregometry either with arachidonic acid or with ADP. Conclusions Our study provides evidence for a correlation of plasma miRNAs with commonly used methods in platelet testing. It highlights that miRNA levels are sensitive to medication, in particular antiplatelet therapy, and preparation of blood samples. This has to be taken into account when designing a study to investigate the relation of circulating miRNAs with cardiovascular disease.
Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs (2013)

We demonstrate that Hh pathway, through EMT-induction, leads to reduced sensitivity to EGFR-TKIs in NSCLCs. Therefore, targeting Hh pathway may lead to the reversal of EMT phenotype and improve the therapeutic efficacy of EGFR-TKIs in NSCLC patients.
Historical development and potential uses of tumor antigens as markers of human cancer growth. (1980)

During the past 30 years, the rapidly developing and changing concepts and technology of the discipline of immunobiology have been applied to studies in oncology. After the definitive demonstration of so-called tumor-specific transplantation antigens in chemically and virally induced tumors in syngeneic rodent and murine species, numerous efforts were then directed toward the demonstration of comparable materials in human tumors. After a number of false starts in an overzealous search for a marker that would serve as a panacea for human cancer diagnosis, more rational approaches have been taken to the problem and valuable information from the points of view of both the cell biologist and clinical oncologist has been forthcoming. The present paper presents an overview of human tumor antigens as biological markers of tumor growth. Reference is made to the fact that normally occurring biological materials of known function that are qualitatively and/or quantitatively altered during the process of malignant transformation may be most useful in the diagnosis and management of the cancer patient. The role of the presently available radioimmunoassays for carcinoembryonic antigen in clinical medicine is outlined.
Fiber Supercapacitors Utilizing Pen Ink for Flexible/Wearable Energy Storage (2012)

A novel type of flexible fiber/wearable supercapacitor that is composed of two fiber electrodes - a helical spacer wire and an electrolyte - is demonstrated. In the carbon-based fiber supercapacitor (FSC), which has high capacitance performance, commercial pen ink is directly utilized as the electrochemical material. FSCs have potential benefits in the pursuit of low-cost, large-scale, and efficient flexible/wearable energy storage systems.
Problems Caused by Ion Sputtering for the Mesh-Replica Method and Caution in Measuring Sputtered Surface Profiles (2005)

The Mesh-Replica Method has been proposed to estimate a sputtering rate of an actual material instead of that of a reference calibration material because this method is easy and convenient. It, however, involves several problems such as (1) a mesh sliding with the specimen assemble wrapped with aluminum foil, (2) formation of a micro-trench at the side of the crater bottom, (3) generation of an artificial profile of sputtered surface mainly due to image processing in AFM (atomic force microscopy) measurements, and (4) leveling difficulty of line profiling with a stylus profilometer because of insufficient retrained areas. In this paper, these examples are demonstrated using proximity observation techniques. In order to solve these problems, we examined the Mesh-Replica Method using an isolated aperture in a thin metal plate, resulting in good stylus profiles with less effort. Finally we propose an asymmetric assortment of apertures that is useful for stylus measurements and assignment of the incident direction of ion beam.
Growth of III-V compounds on vicinal planes by molecular beam epitaxy (1990)

The dynamics of growth of III-V compounds by molecular beam epitaxy can be evaluated experimentally using the temporal variation of the intensity of reflection high-energy electron diffraction patterns. The use of substrate surfaces which are slightly misoriented from an exact low-index plane (vicinal planes) enables direct measurements to be made of cation migration parameters, but a correct analysis requires both step anisotropy and nucleation on the terraces to be taken into account. The experimental results are strongly supported by Monte Carlo simulations of growth, especially with regard to growth mode changes and the anisotropy of cation incorporation at steps. The direct growth of quantum wires (structures giving quantum confinement of carriers in two dimensions) on vicinal planes has been achieved experimentally and it is shown here how the wire quality, as determined by its compositional integrity, can be obtained by the simulation technique. The effects of flux, temperature, misorientation direction and interruptions of growth on quality are demonstrated.
The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37). (1993)

Using the glucose-responsive hamster beta-cell line (hamster insulin tumor cells), we examined the cellular mechanisms by which gastric inhibitory polypeptide (GIP) and glucagon-like peptide I(7-37) (GLP-I) potentiate glucose-stimulated insulin secretion. Glucose alone increased insulin secretion and increased the free cytosolic calcium levels ([Ca2+]i) without altering cAMP content. When added to glucose-stimulated cells, GIP and GLP-I increased cAMP levels and further increased insulin secretion. At 4 mM but not 0.4 mM glucose, both peptides triggered a dose-dependent rise in [Ca2+]i with ED50s of 0.4 and 0.2 nM for GIP and GLP-I, respectively. The increase in [Ca2+]i was blocked by either chelation of extracellular Ca2+ with EGTA or nimodipine, the voltage-dependent Ca2+ channel blocker. Nimodipine also inhibited the potentiation of glucose-stimulated insulin secretion by GIP and GLP-I without inhibition of the stimulatory effect of these two peptides on cAMP accumulation. Neither peptide altered phosphoinositide metabolism, further underlining that the mobilization of intracellular Ca2+ from endoplasmic reticulum is not involved in the GIP and GLP-I signal transduction pathways. This study establishes that GIP and GLP-I potentiate glucose-stimulated insulin secretion by increasing extracellular Ca2+ influx through voltage-dependent Ca2+ channels.
Passive Inter-Domain Routing Monitor Based on Routing Interaction (2006)

Monitoring inter-domain route timely and dynamically is a hard issue. The paper introduces a BGP passive model, and analyzes the possible BGP network events above the established model, proposes a novel approach to monitor BGP network and analyzes BGP dynamics based on the BGP routing interaction. A monitor agent (MA) partially implementing BGP protocol engine is introduced, so that it can listen and receive BGP routing update message by peering with any BGP speaker in the managed BGP network. Based on the collected routing information, the MA can re-construct the BGP topology, and dynamically reflect the topology change triggered by the incoming routing update message, and analyze the BGP network route flap with the inter-arrival time. Comparing with conventional approaches, the proposed approach has better feature in timeliness and dynamicity, and lower overhead incurring in both network and routers.
Poly(vinyl alcohol)/Liquid Crystal Composite Films with Low Driving Voltage (1994)

A poly(vinyl alcohol) (PVA)/liquid crystal (LC) composite film with a low driving voltage of 6 V r m s , a low hysteresis of less than 0.2 V r m s , and a fast response time of 11 ms at the operating voltage of 6 V r m s was formed from the emulsion composed of a mixture of water with methanol (WM-mixture), PVA, LC, and a photocrosslinkable mixture of nonaoxyethylenediacrylate (9EG-A) with perfluorooctylethylacrylate (FA-108). It was found in the composite film that the liquid crystal droplets, surrounded by a thin layer of the photocured polymer, were deformed as well as disordered, which enhanced light scattering.
Mixed Micells: A New Problem-Free Solution for co-123I-Heptadecanoic Acid in Comparison (1984)

The most commonly used reagents for solubilization of 123I fatty acids have very serious drawbacks. Human serum albumin solubilizes the fatty acid only slowly and TWEEN 80 is not free of stability problems. Furthermore adverse reactions in human applications cannot be excluded. In comparison, the newly introduced mixed micells look very favourable: fast solubilization, good stability and no adverse reactions. Biodistribution experiments on rats show an adequate performance of the micells . Hitherto this solution has been applied in more than 200 patients without any complication.
A Framework for Real-Time Service-Oriented Architecture (2009)

Service-oriented architectures (SOA), though widely accepted in a variety of industries, must be enhanced to support real-time activities in order to gain even greater adoption. We present RT-Llama, a novel architecture for real-time SOA to support predictability in business processes. Based on a user-specified process and deadline, our architecture, containing global resource management and business process composition components, can reserve resources in advance for each service in the process to ensure it meets its end-to-end deadline. This is facilitated by also creating a real-time enterprise middleware that manages utilization of local resources by using efficient data structures and handles service requests via reserved CPU bandwidth. We demonstrate that RT-Llama's reservation components are both efficient and adaptable to dynamic real-time environments.
Implantation of the Urethral Stent for Treatment of Complex Urethral Strictures (1991)

We describe the results after implantation of a urethral stent in 6 patients with recurrent urethral strictures. Four patients had strictures located in close vicinity to the external sphincter. In 3 of these 4 patients open urethroplasty procedures had failed. The treatment was successful in 5 of the 6 patients with a follow-up of 6-10 months. However, in 1 patient who had a complex stricture close to the sphincter, dense fibrotic strictures recurred at the proximal end of the stent where a short segment of the stricture was left uncovered in order to preserve continence. We conclude that implantation of the stent is a valuable treatment for complex strictures in the vicinity of the sphincter on condition that the stent covers the whole stricture.
Sinus or not: a new beat detection algorithm based on a pulse morphology quality index to extract normal sinus rhythm beats from wrist-worn photoplethysmography recordings (2018)

The developed algorithm consistently detects normal sinus rhythm beats in a PPG signal by rejecting artefacts and, as a first of its kind, arrhythmic beats. This increases the reliability in the extraction of features which are adversely influenced by the presence of non-sinus pulses, whether related to inter-beat intervals or to pulse morphology, from wrist-worn PPG signals recorded in free-living conditions.
Analysis of Turbofan Design Options for an Advanced Single-Aisle Transport Aircraft (2009)

The desire for higher engine efficiency has resulted in the evolution of aircraft gas turbine engines from turbojets, to low bypass ratio, first generation turbofans, to today's high bypass ratio turbofans. It is possible that future designs will continue this trend, leading to very-high or ultra-high bypass ratio (UHB) engines. Although increased bypass ratio has clear benefits in terms of propulsion system metrics such as specific fuel consumption, these benefits may not translate into aircraft system level benefits due to integration penalties. In this study, the design trade space for advanced turbofan engines applied to a single-aisle transport (737/A320 class aircraft) is explored. The benefits of increased bypass ratio and associated enabling technologies such as geared fan drive are found to depend on the primary metrics of interest. For example, bypass ratios at which fuel consumption is minimized may not require geared fan technology. However, geared fan drive does enable higher bypass ratio designs which result in lower noise. Regardless of the engine architecture chosen, the results of this study indicate the potential for the advanced aircraft to realize substantial improvements in fuel efficiency, emissions, and noise compared to the current vehicles in this size class.
A Radiofrequency-Assisted Minimal Blood Loss Liver Parenchyma Dissection Technique (2007)

The 'sequential coagulate-cut' RF-assisted liver resection technique is a safe liver transection technique associated with minimal blood loss and it has facilitated tissue-sparing liver resection.