gebhart/patrepeval huggingface dataset:
Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy (2015)

Oxidative stress is implicated in the pathogenesis of diabetic kidney injury. SS-31 is a mitochondria-targeted tetrapeptide that can scavenge reactive oxygen species (ROS). Here, we investigated the effect and molecular mechanism of mitochondria-targeted antioxidant peptide SS-31 on injuries in diabetic kidneys and mouse mesangial cells (MMCs) exposed to high-glucose (HG) ambience. CD-1 mice underwent uninephrectomy and streptozotocin treatment prior to receiving daily intraperitoneal injection of SS-31 for 8 wk. The diabetic mice treated with SS-31 had alleviated proteinuria, urinary 8-hydroxy-2-deoxyguanosine level, glomerular hypertrophy, and accumulation of renal fibronectin and collagen IV. SS-31 attenuated renal cell apoptosis and expression of Bax and reversed the expression of Bcl-2 in diabetic mice kidneys. Furthermore, SS-31 inhibited expression of transforming-growth factor (TGF)-β1, Nox4, and thioredoxin-interacting protein (TXNIP), as well as activation of p38 MAPK and CREB and NADPH oxidase activity in diabetic kidneys. In vitro experiments using MMCs revealed that SS-31 inhibited HG-mediated ROS generation, apoptosis, expression of cleaved caspase-3, Bax/Bcl-2 ratio, and cytochrome c (cyt c) release from mitochondria. SS-31 normalized mitochondrial potential (ΔΨm) and ATP alterations, and inhibited the expression of TGF-β1, Nox4, and TXNIP, as well as activation of p38 MAPK and CREB and NADPH oxidase activity in MMCs under HG conditions. SS-31 treatment also could reverse the reduction of thioredoxin (TRX) biologic activity and upregulate expression of thioredoxin 2 (TRX2) in MMCs under HG conditions. In conclusion, this study demonstrates a protective effect of SS-31 against HG-induced renal injury via an antioxidant mechanism in diabetic nephropathy.
A Model Checking Approach for Multi-core Time Partitions Design (2010)

In many areas of safety-critical applications multiple applications must execute on a common machine without disturbing each other. Thus spatial and temporal isolation of each application must be guaranteed. In this paper we address the temporal isolation aspect which can be tackled using time partitioning. We propose a technique for automated design of multi-core time partitions based on characteristics of application workload. The work goes beyond recent work in the literature by effectively computing the parameters of multi-core time partitions, a task which is traditionally done manually by the system designer.
Using Association Metrics to Help Users Navigate API Documentation (2010)

In the past decade there has been spectacular growth in the number and size of third-party libraries, frameworks, toolkits and other Application Programming Interfaces (APIs) available to modern software developers. However, the time-saving advantages of code re-use are commonly hampered by the difficulty in finding the correct methods for a given task among the thousands of irrelevant ones. We have developed a tool called Apatite that helps address this issue by letting programmers browse APIs by viewing associations between their components. Apatite indicates which items of an API are popular in different contexts and allows browsing by initially selecting verbs (methods and actions) in addition to classes and packages. The associations are calculated by leveraging existing search engine data and source code, and verbs are identified by parsing the documentation descriptions. Apatite is available on the web and is being used by developers worldwide on a regular basis.
Amyloid-β and Tau (2014)

The defining features of Alzheimer disease (AD) include conspicuous changes in both brain histology and behavior. The AD brain is characterized microscopically by the combined presence of 2 classes of abnormal structures, extracellular amyloid plaques and intraneuronal neurofibrillary tangles, both of which comprise highly insoluble, densely packed filaments. The soluble building blocks of these structures are amyloid-β (Aβ) peptides for plaques and tau for tangles. Amyloid-β peptides are proteolytic fragments of the transmembrane amyloid precursor protein, whereas tau is a brain-specific, axon-enriched microtubule-associated protein. The behavioral symptoms of AD correlate with the accumulation of plaques and tangles, and they are a direct consequence of the damage and destruction of synapses that mediate memory and cognition. Synapse loss can be caused by the failure of live neurons to maintain functional axons and dendrites or by neuron death. During the past dozen years, a steadily accumulating body of evidence has indicated that soluble forms of Aβ and tau work together, independently of their accumulation into plaques and tangles, to drive healthy neurons into the diseased state and that hallmark toxic properties of Aβ require tau. For instance, acute neuron death, delayed neuron death following ectopic cell cycle reentry, and synaptic dysfunction are triggered by soluble, extracellular Aβ species and depend on soluble, cytoplasmic tau. Therefore, Aβ is upstream of tau in AD pathogenesis and triggers the conversion of tau from a normal to a toxic state, but there is also evidence that toxic tau enhances Aβ toxicity via a feedback loop. Because soluble toxic aggregates of both Aβ and tau can self-propagate and spread throughout the brain by prionlike mechanisms, successful therapeutic intervention for AD would benefit from detecting these species before plaques, tangles, and cognitive impairment become evident and from interfering with the destructive biochemical pathways that they initiate.
Specific inhibition of c- <i>myc</i> protein biosynthesis using an antisense synthetic deoxy-oligonucleotide in human T lymphocytes. (1988)

C-myc protein expression in human T cells was specifically inhibited by a 15-mer deoxy-oligonucleotide complementary to the 5' end of the human c-myc gene second exon. The oligonucleotide penetrates the cells without any treatment, with a plateau of cell association reached in 2 h. The oligonucleotide specifically blocked the de novo synthesis of c-myc protein, induced by PHA in human resting peripheral T cells, without impairing the overall synthesis of other proteins, as shown by two-dimensional analysis of [35S]methionine pulse-labeled proteins. The specific inhibition of c-myc protein synthesis prevented the entry into S phase of resting T cells, induced to proliferate by PHA, or IL-2-dependent T cells induced by IL-2, as shown by [3H]thymidine incorporation. The inhibition of proliferation was specific since it was not observed with the corresponding sense-oligonucleotide and was reversed by preincubation of the cells with an excess of sense oligonucleotide. These results clearly support a role for c-myc protein in the proliferation process and show that inducible protein expression can be blocked by means of synthetic oligonucleotides complementary to a coding exon.
Effectiveness of OLAP-Based Sales Analysis in Retail Enterprises (2008)

Data warehouse and online analytical processing (OLAP) are two significant information technology (IT) strategies. To commercial enterprises, merchandise sales play important and special role. With the market competition getting fierce, managers see information as a critical resource and require methods that let them exploit it for competitive advantage. The development of data warehouse and OLAP make it possible to use these technologies to help managers' analysis and decision making. In this study, we take the case of a drugs retail enterprise, propose a drugs sales data cube and attempt to apply it to drugs sales data OLAP analysis. We give an OLAP structure based on Web. This paper provides the method to realize OLAP data analysis from Web pages through bedding office Web components, and realizes the OLAP multidimensional data analyses.
Species-specific detection of Mycoplasma hyorhinis using DNA probes. (1984)

Two specific DNA fragments from a genomic library of Mycoplasma hyorhinis demonstrated species-specific Southern and dot hybridization using a panel of different mycoplasmas. These probes selectively recognized M. hyorhinis sequences in purified DNA, broth-grown organisms, and infected cell cultures, providing a direct method for differential detection of this mycoplasma species without prior purification of the organism.
FWM penalty reduction in dense WDM systems through channel detuning (2002)

The impact of four wave mixing (FWM) as a function of the channel alignment is studied. A channel plan is proposed which minimizes FWM penalties while still agreeing with the ITU grid. We have shown that in order to demonstrate system performance under the effect of FWM it is necessary to control the alignment of the WDM channels with an accuracy significantly better than the bandwidth of the RX.
Lacemaking by Bedfordshire Paupers in the Late Eighteenth Century (1974)

(1974). Lacemaking by Bedfordshire Paupers in the Late Eighteenth Century. Textile History: Vol. 5, No. 1, pp. 111-118.
NOVA: state assignment of finite state machines for optimal two-level logic implementation (1990)

The problem of encoding the states of a synchronous finite state machine (FSM) so that the area of a two-level implementation of the combinational logic is minimized is addressed. As in previous approaches, the problem is reduced to the solution of the combinatorial optimization problems defined by the translation of the cover obtained by a multiple-valued logic minimization or by a symbolic minimization into a compatible Boolean representation. The authors present algorithms for this solution, based on a novel theoretical framework that offers advantages over previous approaches to develop effective heuristics. The algorithms are part of NOVA, a program for optimal encoding of control logic. Final areas averaging 20% less than other state assignment programs and 30% less than the best random solution have been obtained. Literal counts averaging 30% less than the best random solutions have been obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
One-Pot Synthesis of Ureas from Boc-Protected Amines (2014)

A practical one-pot synthesis of ureas is described. Boc-protected amines can be transformed into nonsymmetrical and symmetrical disubstituted and trisubstituted ureas utilizing 2-chloropyridine and trifluoromethanesulfonyl anhydride for the in situ generation of an isocyanate, which reacts with an amine. A variety of amines can be employed successfully, leading to high yields of isolated ureas.
Effect of Chromium Supplementation on Blood Glucose and Lipid Levels in Type 2 Diabetes Mellitus Elderly Patients (2004)

Intervention trials have shown the beneficial effects of chromium supplementation in type 2 diabetes (non-insulin-dependent diabetes mellitus). This study investigated the effects of chromium picolinate on elderly diabetic patients within a rehabilitation program. Thirty-nine diabetic subjects, average age 73 years (18 males and 21 females), undergoing rehabilitation following stroke or hip fracture, were recruited to participate in this study. An additional 39 diabetic patients constituted the control group. Along with standard treatment for diabetes, the study group received 200 microg of chromium twice a day for a three-week period. Blood samples, dietary intake, and anthropometric data were collected prior to and post-intervention. Throughout the study period, participants received a diet of approximately 1500 kcal/day. Significant differences in the fasting blood level of glucose compared to the baseline (190 mg/dL vs 150 mg/dL, p < 0.001) were found at the end of the study. HbA1c also improved from 8.2% to 7.6% (p < 0.01). Total cholesterol was also reduced from 235 mg/dL to 213 mg/dL (p < 0.02). A trend towards lowered triglyceride levels was also observed (152 mg/dL vs 136 mg/dL). We conclude that, in this population of elderly, diabetic patients undergoing rehabilitation, dietary supplementation with chromium is beneficial in moderating glucose intolerance. In addition, chromium intake appears to lower plasma lipid levels.
MACOP-B Chemotherapy for the Treatment of Diffuse Large-Cell Lymphoma (1985)

Between April 1981 and May 1984, 61 patients with advanced diffuse large-cell lymphoma completed treatment with MACOP-B (methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin), an innovative pilot chemotherapy program emphasizing weekly treatment, antibiotic prophylaxis, daily corticosteroid treatments, and brief duration (12 weeks). Fifty-one patients (84%) achieved a complete response and 10 patients (16%) had a partial response. Over a median follow-up after treatment of 23 months, the actuarial overall survival for the entire group has been 76%; for complete responders the relapse-free survival has been 90%. Toxicity was modest with one treatment-related death and seven episodes of serious infection. The most frequent toxicity was mucositis. Thus, MACOP-B is an effective treatment for large-cell lymphoma that can be delivered in 12 weeks with an acceptable incidence of toxicity. This regimen can achieve results similar and possibly superior to those of other presently used regimens of longer duration.
Characterizations of Modified Silica Nanoparticles(I) (2012)

(3-mercaptopropyl)trimethoxysilane (MPTMS) was used as a silylation agent, and modified silica nanoparticles were prepared by solution polymerization. 2.0 g of silica nanoparticles, 150 ml of toluene, and 20 ml of MPTMS were put into a 300 ml flask, and these mixtures were dispersed with ultrasonic vibration for 60 min. 0.2 g of hydroquinone as an inhibitor and 1 to 2 drops of 2,6-dimethylpyridine as a catalyst were added into the mixture. The mixture was then stirred with a magnetic stirrer for 8 hrs. at room temperature. After the reaction, the mixture was centrifuged for 1 hr. at 6000rpm. After precipitation, 150 ml of ethanol was added, and ultrasonic vibration was applied for 30 min. After the ultrasonic vibration, centrifugation was carried out again for 1 hr. at 6000rpm. Organo-modification of silica nanoparticles with a <TEX>${\gamma}$</TEX>-methacryloxypropyl functional group was successfully achieved by solution polymerization in the ethanol solution. The characteristics of the <TEX>${\gamma}$</TEX>-mercaptopropyl modified silica nanoparticles (MPSN) were examined using X-ray photoelectron spectroscopy (XPS, THERMO VG SCIENTIFIC, MultiLab 2000), a laser scattering system (LSS, TOPCON Co., GLS-1000), Fourier transform infrared spectroscopy (FTIR, JASCO INTERNATIONL CO., FT/IR-4200), scanning electron microscopy (SEM, HITACHI, S-2400), an elemental analysis (EA, Elementar, Vario macro/micro) and a thermogravimetric analysis (TGA, Perkin Elmer, TGA 7, Pyris 1). From the analysis results, the content of the methacryloxypropyl group was 0.98 mmol/g and the conversion rate of acrylamide monomer was 93%. SEM analysis results showed that the organo-modification of ultra-fine particles effectively prevented their agglomeration and improved their dispensability.
Nonchemical Approach for Reducing Antinutritional Factors in Rapeseed (<i>Brassica campestris</i>Var. Toria) and Characterization of Enzyme Phytase (1997)

Antinutritional factors, viz. glucosinolates, phenols, and phytic acid, decreased with germination of rapeseed. Protein content declined during the first 24 h after imbibition and thereafter increased. Phytase activity increased with germination with a parallel decrease in phytic acid content. Two phytase fractions were separated during elution on DEAE-cellulose column, showing purifications of 26.75- and 19.96-fold, respectively. Optimum pH and temperature for both fractions were 5.2 and 50 °C, respectively. Enzyme stability decreased considerably after 50 °C, and phytase 2 was stable for a longer time. Mn, Co, Ca, and EDTA promoted the enzyme activity, whereas ions of Zn, Fe, Cu, fluoride, molybdate, and arsenate were inhibitory. Keywords: Antinutritional factors; characterization; germination; phytase
Tris((hexamethyldisilyl)amido)uranium(III): preparation and coordination chemistry (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTris((hexamethyldisilyl)amido)uranium(III): preparation and coordination chemistryRichard A. AndersenCite this: Inorg. Chem. 1979, 18, 6, 1507–1509Publication Date (Print):June 1, 1979Publication History Published online1 May 2002Published inissue 1 June 1979https://pubs.acs.org/doi/10.1021/ic50196a021https://doi.org/10.1021/ic50196a021research-articleACS PublicationsRequest reuse permissionsArticle Views1560Altmetric-Citations150LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Combined high resolution chromatographic techniques (FPLC and HPLC) and mass spectrometry-based identification of peptides and proteins in Grana Padano cheese (1997)

P Ferranti
Performance of downlink control information signals using decision-feedback channel estimation for EPDCCH (2014)

In the Release (Rel.) 11 Long Term Evolution (LTE)-Advanced radio interface, the Enhanced Physical Downlink Control Channel (EPDCCH) is specified, which transmits downlink control information (DCI) signals. The EPDCCH is frequency-domain-multiplexed with data symbols and is used to transmit more DCI signals than the Physical Downlink Control Channel (PDCCH) for Rel. 8 LTE due to the application of multiuser multiple-input multiple-output (MIMO) and coordinated multi-point (CoMP) transmission and reception. This paper presents the effect of decision-feedback channel estimation (DFCE) using soft-symbol estimation of the DCI signals for the EPDCCH. We propose a DFCE method that improves the channel estimation accuracy by using soft-symbol estimation of the control signals based on the a posteriori log-likelihood ratio (LLR) at the soft output Viterbi algorithm (SOVA) for convolutional coding in addition to the demodulation reference signals (DM-RSs). Computer simulation results show that the DFCE is effective in decreasing the transmission power of the DM-RSs to approximately half compared to that for only conventional DM-RSs to achieve the same target block error rate from a low to high Doppler frequency region in a frequency-selective Rayleigh fading channel.
Avermectin B1: Ingestion and Contact Toxicity Against Spodoptera eridania and Heliothis virescens (Lepidoptera: Noctuidae) and Potentiation by Oil and Piperonyl Butoxide (1986)

Journal Article Avermectin B1: Ingestion and Contact Toxicity Against Spodoptera eridania and Heliothis virescens (Lepidoptera: Noctuidae) and Potentiation by Oil and Piperonyl Butoxide Get access T. E. Anderson, T. E. Anderson Search for other works by this author on: Oxford Academic PubMed Google Scholar J. R. Babu, J. R. Babu Search for other works by this author on: Oxford Academic PubMed Google Scholar R. A. Dybas, R. A. Dybas Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Mehta H. Mehta Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 79, Issue 1, 1 February 1986, Pages 197–201, https://doi.org/10.1093/jee/79.1.197 Published: 01 February 1986 Article history Received: 08 March 1985 Accepted: 12 September 1985 Published: 01 February 1986
Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle (2010)

Muscle specific miRNAs, myomiRs, have been shown to control muscle development in vitro and are differentially expressed at rest in diabetic skeletal muscle. Therefore, we investigated the expression of these myomiRs, including miR-1, miR-133a, miR-133b and miR-206 in muscle biopsies from vastus lateralis of healthy young males (n = 10) in relation to a hyperinsulinaemic–euglycaemic clamp as well as acute endurance exercise before and after 12 weeks of endurance training. The subjects increased their endurance capacity, VO2max (l min−1) by 17.4% (P < 0.001), and improved insulin sensitivity by 19% (P < 0.01). While myomiR expression remained stable during a hyperinsulinaemic–euglycaemic clamp, an acute bout of exercise increased mir-1 (P < 0.05) and mir-133a (P < 0.05) expression before, but not after, training. In resting biopsies, endurance training for 12 weeks decreased basal expression of all four myomiRs (P < 0.05). Interestingly, all myomiRs reverted to their pre-training expression levels 14 days after ceasing the training programme. Components of major pathways involved in endurance adaptation such as MAPK and TGF-β were predicted to be targeted by the myomiRs examined. Tested predicted target proteins included Cdc42 and ERK 1/2. Although these proteins were downregulated between post-training period and 2 weeks of cessation, an inverse correlation between myomiR and target proteins was not found. In conclusion, our data suggest myomiRs respond to physiological stimuli, but their role in regulating human skeletal muscle adaptation remains unknown.
Separation and bearing estimation of co-channel signals (2003)

The authors describe a technique for simultaneously estimating the bearing of and separating (copying) multiple cochannel signals received by a multielement antenna array. The method uses a combination of adaptive beamformers and signal cancelers to sequentially lock onto and remove emitters one by one from the element signals. Inherent to the technique is the generation of a direction vector for each of the isolated emitters. The technique requires neither prior knowledge of emitter bearings nor array calibration is required only to map direction vectors into bearing estimates. The technique is computationally simple and easily amenable to hardware implementation. For reasonably narrowband signals (<50 kHz), the method is simple enough to make real-time implementation using programmable digital signal processing hardware possible. Computer simulations are presented to demonstrate the technique's operation and robustness.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Neural Network for nanoscale architecture (2006)

In this paper, we investigate the use of analog neural networks to implement small logic function like Look Up Tables (LUT) in FPGA circuits (Field Programmable Gate Arrays). For that purpose, we present an architecture using tunable resistors or, alternatively, an original CNT-FET based synaptic cell. Finally, simulations demonstrate that learning using the Boltzmann machine algorithm can correct a defective circuit.