gebhart/patrepeval huggingface dataset:
Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-gamma-producing (Th1) cells (1992)

As a model for understanding in vivo immune responses, we have exposed mice to aqueous haptenated-protein Ag, and examined immune responses to subsequent immunization with Ag in adjuvant. Pretreating mice with soluble, TNP-conjugated Ag induces selective nonresponsiveness to Ag for both humoral and cell-mediated immune functions. Specific T cell proliferation in response to Ag is inhibited, and Ag-induced secretion of the lymphokines IL-2 and IFN-gamma, but not IL-4, is reduced. B cell responses after pretreatment are also affected. Although levels of TNP-specific IgG1 and IgE are similar in treated and untreated mice, soluble Ag pretreatment diminishes production of TNP-specific IgG2a and IgG2b. This is due to lack of T cell help and is not caused by tolerance in the B cell compartment. These results indicate that pretreatment of mice with aqueous Ag induces selective unresponsiveness in Th1-like Th cells, which secrete IL-2 and IFN-gamma, but not in Th2-like Th cells, which secrete IL-4.
Duration of immunity to reinfection with tick-transmitted Borrelia burgdorferi in naturally infected mice (1997)

The ability of naturally infected and cured mice to resist reinfection with tick-transmitted Borrelia burgdorferi was tested over a 1-year period. All of the mice were resistant to reinfection when they were challenged at 1.5 months after cure. The majority of animals were resistant to reinfection for up to 10.5 months after cure, but this resistance was lost at 1 year after cure. Both protected and unprotected animals showed a diverse array of antibodies on Western immunoblots. Protection was not associated with the killing of spirochetes in ticks, and naturally infected mice produced no antibodies to outer surface protein A (OSP A). The titers to whole Borrelia sonicate and OSP C, however, remained high throughout the 1-year study period. The levels of borreliacidal antibodies were highest in the 1.5 month-after-cure group. Natural immunity to reinfection with B. burgdorferi is limited in time, is complex, and may involve both humoral and cellular components.
Perchlorate Chemistry: Implications for Analysis and Remediation (1998)

Since the discovery of perchlorate in the ground and surface waters of several western states, there has been increasing interest in the health effects resulting from chronic exposure to low (parts per billion [ppb]) levels. With this concern has come a need to investigate technologies that might be used to remediate contaminated sites or to treat contaminated water to make it safe for drinking. Possible technologies include physical separation (precipitation, anion exchange, reverse osmosis, and electrodialysis), chemical and electrochemical reduction, and biological or biochemical reduction. A fairly unique combination of chemical and physical properties of perchlorate poses challenges to its analysis and reduction in the environment or in drinking water. The implications of these properties are discussed in terms of remediative or treatment strategies. Recent developments are also covered.
Membrane Systems Associated with the Plasmalemma of Plant Cells (1968)

Vesicular and membranous structures associated with the plasmalemma in both higher and lower plants have been examined using different methods of fixation; this, together with an analysis of similar structures illustrated in other published results, has led to the conclusion that such formations are not artifacts. It is suggested that all membranous or vesicular structures associated with the plasmalemma are classified under the general term—paramural body—regardless of their origin. These paramural bodies are subdivided into two classes according to their derivation. Lomasomes are derived from cytoplasmic membranes, while plasmalemmasomes are formed entirely from the plasmalemma. Paramural bodies may in some cases be involved in wall synthesis, either as a transitory stage during the incorporation of wall precursors or as the site of incorporation of enzymes for extracellular syntheses. Analysis of cell membranes using a microdensitometer lends support to the postulated derivation of paramural body membranes, as also do observations on the apparent polarity of paramural body membranes compared with the polarity of the plasmalemma.
In vitro fertilization: an overview. (1989)

The advanced reproductive technologies are an acceptably safe but invasive method to treat infertility. The decision to proceed with IVF/ET should be based on 1) a complete infertility investigation, 2) an understanding by the couple of the emotional, physical and financial aspects of the process and 3) an understanding by physicians of the real advantages and disadvantages of the procedures.
Enhancing Positioning Accuracy in Urban Terrain by Fusing Data from a GPS Receiver, Inertial Sensors, Stereo-Camera and Digital Maps for Pedestrian Navigation (2012)

The paper presents an algorithm for estimating a pedestrian location in an urban environment. The algorithm is based on the particle filter and uses different data sources: a GPS receiver, inertial sensors, probability maps and a stereo camera. Inertial sensors are used to estimate a relative displacement of a pedestrian. A gyroscope estimates a change in the heading direction. An accelerometer is used to count a pedestrian's steps and their lengths. The so-called probability maps help to limit GPS inaccuracy by imposing constraints on pedestrian kinematics, e.g., it is assumed that a pedestrian cannot cross buildings, fences etc. This limits position inaccuracy to ca. 10 m. Incorporation of depth estimates derived from a stereo camera that are compared to the 3D model of an environment has enabled further reduction of positioning errors. As a result, for 90% of the time, the algorithm is able to estimate a pedestrian location with an error smaller than 2 m, compared to an error of 6.5 m for a navigation based solely on GPS.
Subband speech coding and matched convolutional channel coding for mobile radio channels (1991)

The effects of digital transmission errors on a family of variable-rate embedded subband speech coders (SBC) are analyzed in detail. It is shown that there is a difference in error sensitivity of four orders of magnitude between the most and the least sensitive bits of the speech coder. As a result, a family of rate-compatible punctured convolutional codes with flexible unequal error protection capabilities have been matched to the speech coder. These codes are optimally decoded with the Viterbi algorithm. Among the results, analysis and informal listening tests show that with a 4-level unequal error protection scheme transmission of 12 kb/s speech is possible with very little degradation in quality over a 16 kb/s channel with an average bit error rate (BER) of 2*10/sup -2/ at a vehicle speed of 60 m.p.h. and with interleaving over two 16 ms speech frames.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes. (1994)

We describe a double-label in situ hybridization protocol based on the optimized synthesis of biotin-labeled RNA probes. Biotin-labeled probes are used in conjunction with digoxigenin-labeled probes to simultaneously visualize two different transcripts. One transcript is hybridized with a biotin-labeled RNA probe and visualized as a brown peroxidase reaction product, and the other transcript is hybridized with a digoxigenin-labeled RNA probe and visualized as a blue alkaline phosphatase reaction product. We present several examples in which this double-labeling method has proven useful in determining the spatial and temporal relationships between various transcripts expressed during Drosophila embryogenesis, indicating that this method should be of general use in establishing the relationship of two independent transcription patterns.
HVPE of Orientation-Patterned Gallium Phosphide (OP-GaP) with Novel Quasi-Phasematched Device Structures (2018)

We report the successful growth and fabrication of engineered quasi-phasematched grating structures - parallel gratings, tandem gratings, linear- and curved fan gratings, and chirped gratings - in the new nonlinear optical semiconductor OP-GaP.
Spectrophotofluorometric Determination of Porphyrins in Urine (1971)

Abstract A rapid procedure has been developed in which an anion-exchange resin and spectrophotofluorometry are used to determine total porphyrins in urine. After porphyrins are eluted from the resin with 3N HCl, their fluorescence at 646 nm is measured with an Aminco-Bowman Spectrophotofluorometer. About 10 min are required per analysis by a skilled technician. Added to urine specimens, 95.3 ± 4.9% of uroporphyrin and 94.7 ± 9.6% of coproporphyrin, were accounted for. Eighteen normal urine samples contained an average of 0.063 µmol of porphyrin per liter (range, 0.028-0.176 µmol/liter). The coefficient of variation, 2.9%, indicates the precision to be very satisfactory.
HMOG: A New Biometric Modality for Continuous Authentication of Smartphone Users. (2015)

In this paper, we introduce Hand Movement, Orientation, and Grasp (HMOG), a behavioral biometric to continuously authenticate smartphone users. HMOG unobtrusively captures subtle micro-movement and orientation dynamics resulting from how a user grasps, holds, and taps on the smartphone. We evaluated the authentication and biometric key generation (BKG) performance of HMOG features on typing data collected from 100 subjects. Data was collected under two conditions: sitting and walking. We achieved authentication EERs as low as 6.92% (walking) and 10.20% (sitting) when we combined HMOG, tap, and keystroke features. We performed additional experiments to investigate why HMOG features perform well during walking. Our results suggest that this is due to the ability of HMOG features to capture distinctive body movements caused by walking, in addition to the hand-movement dynamics from taps. With BKG, we achieved EERs of 13.7% using HMOG combined with taps. In comparison, BKG using tap, key hold, and swipe features led to EERs between 31.3% and 36.7%. We also analyzed the energy consumption of HMOG feature extraction and computation. Our analysis shows that HMOG features extracted at 16Hz sensor sampling rate incurred a minor overhead of 7.9% without sacrificing authentication accuracy.
M3: Multiscale, Deterministic and Reconfigurable Macro-Micro Assembly System for Packaging of MEMS (2007)

This paper presents recent results in configuring a multiscale (macro-micro) robotic assembly platform with modular and reconfigurable characteristics. M3 is a multi-robot system capable of spanning across the macro-meso-micro scales, and has been specifically designed to package MOEMS (Micro Opto Electro Mechanical Systems). The emphasis on packaging (as opposed to assembly) is inclusive of the latter, but it also recognizes that bonding, sealing and attachment processes must also be controlled, and will greatly influence the reliability of the microsystem. The system components include precision robots, microstages, end-effectors and fixtures that accomplish assembly tasks in a shared workspace. The system components are systematically characterized in terms of accuracy and repeatability, and assembly plans are performed using kinematic identification, visual servoing, inverse kinematics, and dynamic vibration suppression. As an application packaging problem, various micro and mesoscale parts are assembled into a MEMS device. The tolerance budget of assembly ranges from 4 microns to 300 microns, while the size of components in the assembly ranges from 126 microns to 30mm. Various end-effectors and fixtures have been designed for use with off-the-shelf hardware (robots and microstages) and were tested for precision performance. The robots are calibrated to accuracies of 10 microns or less. In this paper we present experimental results of precision robot calibration and visual servoing for fiber pigtailing with one of the robots within M3
Mechanism for Intercalation of Kaolinite by Alkali Acetates (1966)

The relative strengths of the hydrogen bonds in kaolinite-alkali salt-water systems control kaolinite-salt interactions. A new technique for intercalation results in formation of a kaolinite-salt complex free of excess salt.
Modified Wiener estimation of diffuse reflectance spectra from RGB values by the synthesis of new colors for tissue measurements (2012)

We present a new method for the accurate estimation of diffuse reflectance spectra from RGB values based on Wiener estimation. In the proposed method, a system matrix obtained from the original RGB values is combined with a set of synthetic optical filters to generate another three values corresponding to new colors. A modified Wiener matrix can then be created with the original RGB values and the new color values, which will yield a more accurate estimation because of the new color information that has been incorporated. This method was tested on in vivo color measurements from 200 skin sites in 10 volunteers. The results show that the proposed method is able to improve the estimation accuracy significantly compared with the traditional Wiener estimation method. The fast speed of this method may enable the estimation of diffuse reflectance spectra at multiple tissue locations from color images in real time, which provides a cost-effective alternative to spectral imaging with the additional advantage of high spectral resolution.
An optimal k-exclusion real-time locking protocol motivated by multi-GPU systems (2021)

Graphics processing units (GPUs) are becoming increasingly important in today's platforms as their growing generality allows for them to be used as powerful co-processors. In previous work, the authors showed that GPUs may be integrated into real-time systems by treating GPUs as shared resources, allocated to real-time tasks through mutual exclusion locking protocols. In this paper, an asymptotically optimal k-exclusion locking protocol is presented for globally-scheduled job-level static-priority (JLSP) systems. This protocol may be used to manage a pool of resources, such as GPUs, in such systems.
Parallel pseudospectral electronic structure: I. Hartree-Fock calculations (1998)

We present an outline of the parallel implementation of our pseudospectral electronic structure program, Jaguar, including the algorithm and timings for the Hartree–Fock and analytic gradient portions of the program. We also present the parallel algorithm and timings for our Lanczos eigenvector refinement code and demonstrate that its performance is superior to the ScaLAPACK diagonalization routines. The overall efficiency of our code increases as the size of the calculation is increased, demonstrating actual as well as theoretical scalability. For our largest test system, alanine pentapeptide [818 basis functions in the cc-pVTZ(-f) basis set], our Fock matrix assembly procedure has an efficiency of nearly 90% on a 16-processor SP2 partition. The SCF portion for this case (including eigenvector refinement) has an overall efficiency of 87% on a partition of 8 processors and 74% on a partition of 16 processors. Finally, our parallel gradient calculations have a parallel efficiency of 84% on 8 processors for porphine (430 basis functions). © 1998 John Wiley & Sons, Inc. J Comput Chem 19: 1017–1029, 1998
Identification of a Major Non-structural Protein in the Nuclei of Rift Valley Fever Virus-infected Cells (1982)

A non-structural protein of mol. wt. 34 X 10(3) was demonstrated in the nuclei of Rift Valley fever virus-infected Vero cells by SDS-polyacrylamide gel electro-phoresis. The protein appears to correspond to the virus-induced antigen demonstrated by indirect immunofluorescence in intranuclear inclusions.
Restricted T cell receptor expression by human T cell clones specific for mycobacterial 65‐kDa heat‐shock protein: Selective <i>in vivo</i> expansion of T cells bearing defined receptors (1993)

We have examined the T cell receptor (TcR) expression of clones specific for epitopes of mycobacterial 65-kDa heat-shock protein (hsp65) in the context of two different HLA molecules, and used this system as a model to assess the selection of T cells responsive to this antigen in vivo. DR3-restricted clones were raised from both the synovial fluid (SF) and peripheral blood (PB) of a patient with reactive arthritis in three separate cloning events. Five of five SF-derived clones tested expressed either V beta 5.2 or a closely related beta chain, V beta 5.6. The alpha chains expressed by V beta 5.2+ and V beta 5.6+ clones were from different families, V alpha 2.4 and V alpha 23.2, respectively. Nine of ten clones derived from two cloning procedures on PB taken 3 years later also expressed either V beta 5.2 or V beta 5.6. This suggests that the TcR repertoire for recognizing this major histocompatibility complex/peptide complex is relatively restricted and favors the use of V beta 5. Conservation of the beta chain third complementarity-determining region (CDR3) sequence was not evident, however. Sequencing alpha and beta chains of representative V beta 5.2+ and V beta 5.6+ PB-derived clones revealed TcR which were identical to those utilized by the SF-derived clones, showing that the repertoire for recognition of this antigen is stable over time. Similar studies of TcR expression were carried out on hsp65-specific, DP4-restricted clones derived from the SF of a patient with rheumatoid arthritis by two independent cloning procedures. There was conservation of alpha chain usage, since all clones expressed a member of the V alpha 1 family, but again CDR3 sequence conservation was not apparent. beta chain usage was not restricted since different clones expressed V beta 6.7, V beta 22.3 and V beta 12. Subtle differences in epitope specificity were detected for two clones with differing TcR. Once more, T cell clones with identical alpha and beta TcR chains were obtained from the separate cloning procedures, suggesting oligoclonalty of T cells with this defined specificity in the patient's SF.
Prosaposin is a novel androgen‐regulated gene in prostate cancer cell line LNCaP (2006)

Androgen-regulated genes (ARG) are implicated in normal and neoplastic growth of the prostate. Recently, we reported genomic amplification and/or overexpression of a previously known neurotrophic factor, prosaposin, in androgen-independent (AI) or metastatic prostate cancer (PCa) cells and tissues. Prosaposin and/or its known active molecular derivatives (e.g., saposin C) function as a pluripotent growth factor with diverse biological activities that favor malignant phenotypes in PCa cells. In addition, prosaposin or saposin C upregulates androgen receptor (AR) and AR-target genes (i.e., prostate-specific antigen, Probasin) expression and activity in LNCaP cells. Here, we examined prosaposin as an ARG. We report that DHT treatment of LNCaP cells increases prosaposin expression. In addition, we demonstrate androgen-responsiveness of prosaposin promoter and AR occupancy to a hormone-responsive element located in the proximal region of the prosaposin promoter. Our data for the first time identify prosaposin as an ARG. This observation, together with the pleiotropic growth factor activity of prosaposin, might suggest a role for this molecule in AR-dependent progression of prostate cancer at its early or late AI-state.
Design of a Dynamic Priority-Based Fast Path Architecture for On-Chip Interconnects (2007)

In modern multi-core system-on-chip (SoC) architectures, the design of innovative interconnection fabrics is indispensable. The concept of the network-on-chip (NoC) architecture has been proposed recently to better suit this requirement. Especially, the router architecture has a significant effect on the overall performance and energy consumption of the chip. We propose a dynamic path management scheme that exploits network traffic information during switch arbitration. Consequently, flits transferred across frequently used paths are expedited by traversing a reduced router pipeline. This technique, based on pipeline bypassing, is simulated and evaluated in terms of network latency and average power consumption. Simulation results with real-world application traces show that the architecture improves the performance up to 30% while incurring only minimal area/power overhead.
The Respiratory Metabolism of Collembola Species from a Danish Beech Wood (1981)

The respiratory rates of 11 species or species-groups were measured at three temperatures by open gradient respirometry. The relationship between respiratory rate and dry weight agrees with the allometric equation: R = a * Wb. A pooled estimate of b was calculated for each species based on the lack of significance between the exponents found at each of the three temperatures. Most species have respiration-weight exponents between 0.75 and 0.85 which agree with the values most frequently recorded for poikilotherms. The pooled exponent of 0.96 for Tomocerus flavescens (Tullberg) indicates weight-proportional respiration. The elevation of the log respiratory/log dry weight regression line for deeper living species lies lower than for more superficially living species. A single function cannot describe the relationship between respiratory rate adjusted to metabolically effective body size and temperature for different species, but a preliminary exponential relationship is adopted. The Q10 values (range 1.9-3.4) agree for most species with published values for arthropods, but Tomocerus flavescens differs significantly by a high Q 10 of 5.2.
Celestial polarization patterns during twilight (2006)

Scattering of sunlight produces patterns of partially linearly polarized light in the sky throughout the day, and similar patterns appear at night when the Moon is bright. We studied celestial polarization patterns during the period of twilight, when the Sun is below the horizon, determining the degree and orientation of the polarized-light field and its changes before sunrise and after sunset. During twilight, celestial polarized light occurs in a wide band stretching perpendicular to the location of the hidden Sun and reaching typical degrees of polarization near 80% at wavelengths >600 nm. In the tropics, this pattern appears approximately 1 h before local sunrise or disappears approximately 1 h after local sunset (within 10 min. after the onset of astronomical twilight at dawn, or before its end at dusk) and extends with little change through the entire twilight period.
Practical Multigram Synthesis of 3,3,3',3'-Tetramethyl-1,1'-spirobisindane-5,5'-diamino-6,6'-diol (2013)

with a spirobisindanemoiety have been developed. One of the key monomers is3,3,3',3'-tetramethyl-1,1'-spirobisindane-5,5'-diamino-6,6'-diol (6) as shown in Scheme 1. A few known syntheticmethods of 6 are a direct nitration of 3,3,3',3'-tetramethyl-1,1'-spirobisindane-6,6'-diol (2) with nitric acid followed byreduction using HCO
The Validity of the Equation <i>P = Tdv/dT</i> in Thermo-Electricity (1918)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Functional reactivity of 5-HT receptors in human umbilical cord and maternal subcutaneous fat arteries after normotensive or pre-eclamptic pregnancy (2006)

In both UCA and SFA, 5-HT1B/1D and 5-HT2A receptors mediate vasoconstriction. The sensitivity of 5-HT1B/1D receptors increases in the last trimester in the UCA in normal pregnancies, which seems to be expedited in pre-eclamptic patients. Further studies on 5-HT1B/ID receptors will thus give new insights into the foetal development and pathophysiology of pre-eclampsia.