gebhart/patrepeval huggingface dataset:
Comparative characterization of the leukocidic and hemolytic activity of Moraxella bovis (1990)

The cytotoxic effect of Moraxella bovis 118F on bovine neutrophils was evaluated and characterized by use of a 51Cr release assay. Neutrophils harvested from healthy adult cattle were labeled with 51Cr. The leukocidic activity produced by M bovis 118F, a hemolytic strain of M bovis, was heat-labile. A live culture of strain 118F, at a ratio of 100 bacteria/neutrophil, released 97.7% of the 51Cr from labeled neutrophils. Neither a heat-killed preparation of M bovis 118F nor a live or heat-killed preparation of M bovis IBH63 (a nonhemolytic and nonpathogenic strain) induced significant (P greater than 0.05) release of 51Cr. Moraxella bovis 118F broth culture filtrates prepared for evaluation of leukocidic activity also were evaluated for hemolytic activity. These 2 toxic activities had several characteristics in common. Both were filterable, heat-labile, produced by a hemolytic strain, and were released during early logarithmic phase growth from broth cultures. Leukocidic and hemolytic activities were protected from degradation by phenylmethyl sulfonyl fluoride, a serine protease inhibitor. Leukocidic and hemolytic activities were dependent on calcium ions. Filtrate resulted in 54.1% 51Cr release from labeled neutrophils and contained 646.7 hemolytic U/ml, respectively, when saline (0.85% NaCl) + 10 mM CaCl2 solution was used as diluent. Neither saline solution nor saline + 10 mM MgCl2 solution supported leukocidic or hemolytic activity. Serum, obtained from several calves 10 to 38 days after M bovis inoculation, substantially neutralized leukocidic and hemolytic activities, compared with paired preinoculation serum samples.(ABSTRACT TRUNCATED AT 250 WORDS)
Digital Control Loading - A Modular Approach (1983)

Reflectone has recently completed final development of a high quality digital feedback control system used to control forces developed by a hydrostatic actuator based flight control loading system for a flight simulator. This system represents a significant advance in the state of the art over the commonly used analog systems. This paper will present the basic design and capabilities of the technique, as well as point out various steps taken during design and development to insure a low cost, low maintenance, highly reliable system capable of extremely high fidelity simulation of a wide variety of aircraft.
Medication adherence and cognition. Medical, personal and economic factors influence level of adherence in older adults. (2006)

Medication adherence is increasingly being recognized as a significant issue in treating geriatric patients. A report by the Institute of Medicine1 identified medication nonadherence as a notable source of medical errors.

Poor adherence has been shown to decrease the effects of prescribed medications or other treatments and to increase the likelihood of poor outcomes.2 Adherence has been related to intermediate clinical outcomes in several diseases. An increased incidence of adverse events has been linked to nonadherence in the elderly.3

Elders' adherence to prescribed medications is a complex phenomenon that depends on an interaction of medical, medication, personal, and economic factors.


Medical factors that affect adherence include cognitive abilities, as well as overall health status (eg, number of chronic conditions).


Medication factors related to adherence include the characteristics of the medication (eg, dosing frequency or presence of side effects).


Personal factors that affect adherence include: 

personal beliefs about the condition for which the medication is prescribed (eg, how serious the condition is and how likely the medication is to have a positive effect).


individual cognitive abilities, including memory, overall intellectual ability, organization skills, and health literacy. Health literacy has emerged as an important factor that affects older persons' capacity, for example, to make health care choices.4





Economic factors pertinent to medication adherence include whether patients have insurance or other financial resources to pay for the medication.


Patients' relationship with their physician as well as the physician's communication style can affect adherence.5


In the older adult with memory problems, we have found that whether patients depend on themselves or a caregiver can have a significant impact on adherence.6 Not all caregivers take responsibility for a patient's medication, and family members' beliefs about a medication can also affect the patient's adherence.



Evaluation of elders' medication adherence as a factor in treatment success or failure is thus potentially complex, difficult, and time consuming.
SONET/SDH: A Sourcebook of Synchronous Networking (1996)

From the Publisher:
Gain a comprehensive and up-to-date knowledge of SONET/SDH synchronous networking with this edited anthology of new, original contributions and classic, seminal papers from the foremost leaders in the field. Accurate, logically formatted, and complete with excellent diagrams, this book will be invaluable to communication network and switching engineers who want to stay on the cutting edge of this developing technology. It is adopted by virtually all leading global carriers and equipment.
A Single 16S Ribosomal RNA Substitution Is Responsible for Resistance to Amikacin and Other 2‐Deoxystreptamine Aminoglycosides in<i>Mycobacterium abscessus</i>and<i>Mycobacterium chelonae</i> (1998)

Twenty-six clinical isolates of Mycobacterium abscessus resistant to amikacin were identified. Most isolates were from patients with posttympanostomy tube placement otitis media or patients with cystic fibrosis who had received aminoglycoside therapy. Isolates were highly resistant (MICs > 1024 microg/mL) to amikacin, kanamycin, gentamicin, tobramycin, and neomycin (all 2-deoxystreptamine aminoglycosides) but not to streptomycin. Sequencing of their 16S ribosomal (r) RNA revealed that 16 (94%) of 17 had an A-->G mutation at position 1408. In vitro-selected amikacin-resistant mutants of M. abscessus and Mycobacterium chelonae had the same resistance phenotype, and 15 mutants all had the same A-->G substitution at position 1408. Introducing an rRNA operon from Mycobacterium smegmatis with a mutated A-->G at this position into a single functional allelic rRNA mutant of M. smegmatis produced the same aminoglycoside resistance phenotype. These studies demonstrate this 16S rRNA mutation is responsible for amikacin resistance in M. abscessus, which has only one copy of the rRNA operon.
Solubility of Carcinogenic and Related Hydrocarbons in Water (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of Carcinogenic and Related Hydrocarbons in WaterW. W. Davis, M. E. Krahl, and G. H. A. ClowesCite this: J. Am. Chem. Soc. 1942, 64, 1, 108–110Publication Date (Print):January 1, 1942Publication History Published online1 May 2002Published inissue 1 January 1942https://pubs.acs.org/doi/10.1021/ja01253a028https://doi.org/10.1021/ja01253a028research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Contribució al coneixement del bivalve eocènic Eufistulana chiae (Vidal, 1882) (1998)

The endothelium profoundly affects subjacent vascular smooth muscle function. An analogous relationship between endothelial endocardial cells (EEC) and the myocardium is suggested by Brutsaert et al.'s observation that EEC modulate the contractility of subjacent myocardium. Prostanoids are a major product by which vascular endothelium affects smooth muscle, but similar prostanoid production by EEC has not been described. To determine whether both right and left ventricular EEC produce prostacyclin (PGI2) and prostaglandin E2 (PGE2), ovine EEC were cultured. EEC prostanoid production was measured under basal conditions and after stimulation with arachidonic acid or calcium ionophore A23187. EEC from both ventricles demonstrated sustained prostacyclin and PGE2 production. Prostacyclin production was 10 times greater than PGE2. These results suggest that endocardial prostanoid production could act both locally, to modulate platelet and myocardial function, and distally, on downstream vascular tone.
Nitric Oxide-Releasing Xerogel-Based Fiber-Optic pH Sensors (2006)

A xerogel-based optical pH sensor capable of releasing low levels of nitric oxide (NO) and measuring changes in solution pH is reported. Through simple dip-coating procedures, aminoalkoxysilane-based xerogel films modified with N-diazeniumdiolate NO donor precursors and the fluorescent pH indicator seminaphthorhodamine-1 carboxylate (SNARF-1) were sequentially deposited onto optical fibers. The resulting sensors were characterized by fast and linear response to pH throughout the physiological range (pH 7.0-7.8). Real-time chemiluminescence measurements confirmed that the presence of the overlying SNARF-1-containing TMOS layer did not have an inhibitory effect on N-diazeniumdiolate formation or NO release, and the NO-releasing coatings were capable of maintaining NO fluxes >0.4 pmol/cm(2) s up to 16 h. In vitro blood compatibility studies using porcine platelets confirmed the expected thromboresistivity of the NO-releasing xerogel coatings.
Attention Deficit Hyperactivity Disorder in adulthood (1999)

A thorough review of the literature for adults with ADHD was carried out and generally the outlook was discouraging. It was clear that childhood ADHD posed a risk for adverse outcome, including a continuation of core cognitive and behavioural deficits. However, a shortage of data about adults was revealed as most studies in the literature examine the disorder in childhood and follow them up only into adolescence. Issues of comorbidity and precise neuropsychological deficits in adulthood were unknown. It was hypothesised that clinically referred adults with ADHD would present with academic underachievement, poor occupational adjustment, antisocial and criminal behaviour, poor social interaction and relationship difficulties. It was hypothesised that they would have comorbid personality disorder, make a greater number of errors on cognitive measures of attention and impulsiveness, and overestimate on a time estimation task. These hypotheses were examined in a clinically referred sample of (1) ADHD adults, comparing them with (2) a matched clinically referred control group and (3) a matched community control group. Generally the hypotheses were supported and the pattern of results emphasised the developmental nature of the disorder. The ADHD group was significantly more impaired than the normal control group on all measures. The ADHD group was more impaired than the clinic control group on childhood measures of academic underachievement, antisocial and criminal behaviour. There was a suggestion that antisocial personality problems were present in adulthood. Cognitive testing clearly differentiated the ADHD group from the control groups, they made more error scores and were more impaired in their perception of time. Adult diagnosis was validated by relating a behavioural diagnosis of ADHD in adulthood and predicting this to their cognitive deficits. The long-term consequence of ADHD is a source of concern, particularly considering that it is largely understood to be a problem of childhood and not commonly recognised or accepted by clinicians as a disorder of adulthood. The implications of the results for research and clinical practice are discussed in the conclusion.
Heterocycle-Activated Aromatic Nucleophilic Substitution of AB<sub>2</sub> Poly(aryl ether phenylquinoxaline) Monomers. 3 (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTHeterocycle-Activated Aromatic Nucleophilic Substitution of AB2 Poly(aryl ether phenylquinoxaline) Monomers. 3S. Srinivasan, R. Twieg, J. L. Hedrick, and C. J. HawkerView Author Information IBM Research Division, Almaden Research Center, 650 Harry Road, San Jose, California 95120-6099Cite this: Macromolecules 1996, 29, 26, 8543–8545Publication Date (Web):December 16, 1996Publication History Received1 July 1996Revised16 September 1996Published online16 December 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ma960939yhttps://doi.org/10.1021/ma960939ybrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views400Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ethers,Monomers,Polymerization,Polymers,Solvents Get e-Alerts
Lithography budget analysis at the process module level (2006)

A simple experimentally characterized lumped-parameter budget model is developed with the goal of quantifying the most significant components of critical dimension (CD) variation through an integrated process module. Tracked components include mask fabrication budgets, mask error factor, scanner field variation, optical proximity correction error, CD errors over chip topography, wafer-to-wafer and lot-to-lot variation. The components of variation are quantified for lithography and etch where appropriate and are fed into a simple interaction model to construct an overall patterning module CD budget. Normalized experimental results for this budget analysis are presented for 65 nm technology node contact patterning processes.
Multi-MHz FDML OCT: snapshot retinal imaging at 6.7 million axial-scans per second (2012)

We demonstrate the acquisition of densely sampled wide-field 3D OCT datasets of the human retina in 0.3s. This performance is achieved with a multi-MHz Fourier domain mode-locked (FDML) laser source operating at 1050nm. A two-beam setup doubles the 3.35MHz laser sweep rate to 6.7MHz, which is 16x faster than results achieved with any non-FDML source used for retinal OCT. We discuss two main benefits of these high line rates: First, large datasets over an ultra-wide field of view can be acquired with a low probability of distortions. Second, even if eye movements occur, now the scan rate is high enough to directly correct even the fastest saccades without loss of information.
Gemcitabine: Future Prospects of Single-Agent and Combination Studies (1997)

Gemcitabine (2'2'-difluorodeoxycytidine, Gemzar) is a deoxycytidine analog with excellent antitumor activity against a number of solid tumors. Gemcitabine needs to be activated by deoxycytidine kinase and other kinases to its triphosphate, gemcitabine triphosphate, which can be incorporated into RNA and DNA. The latter effect is considered to be responsible for its antitumor effect and causes masked chain termination and inhibition of DNA repair. This effect may be of importance for combination with DNA interacting agents. In phase I trials daily, twice weekly, weekly and every two weeks schedules have been evaluated. At the weekly schedule of 1,000-1,250 mg/m² significant antitumor activity was observed in bladder, breast, ovary, and pancreatic cancer, non-small cell lung cancer (NSCLC), and small cell lung cancer of 31%, 33%, 22%, 11%, 22% and 27% total response rates, respectively. Gemcitabine also showed considerable improvement in clinical symptoms, while toxicity was not severe with mild myelosuppression. Due to its ability to inhibit DNA replication, combination studies were initiated with DNA damaging agents. For the various combinations with cisplatin in phase II studies on NSCLC, response rates varied from 42%-54%, with a median survival of generally more than 12 months. Also, combinations with taxanes, etoposide, doxorubicin and vindesin seem promising. Gemcitabine is an important agent for the management of several relatively chemoresistant cancer types, both with respect to anti-tumor activity and clinical benefit. Future research on combination studies deserves high priority considering the high response rates in NSCLC and bladder cancer.
Each to his own (2011)

This paper compares five different ways of interacting with an attribute-based recommender system and shows that different types of users prefer different interaction methods. In an online experiment with an energy-saving recommender system the interaction methods are compared in terms of perceived control, understandability, trust in the system, user interface satisfaction, system effectiveness and choice satisfaction. The comparison takes into account several user characteristics, namely domain knowledge, trusting propensity and persistence. The results show that most users (and particularly domain experts) are most satisfied with a hybrid recommender that combines implicit and explicit preference elicitation, but that novices and maximizers seem to benefit more from a non-personalized recommender that just displays the most popular items.
Dissolved PCBs, PAHs, and HCB in Pore Waters and Overlying Waters of Contaminated Harbor Sediments (2003)

Aqueous concentrations of polychlorinated biphenyls (PCBs), polyaromatic hydrocarbons (PAHs), pentachlorobenzene, and hexachlorobenzene (HCB) were determined by exposing low-density polyethylene (LDPE) strips to the pore waters and the overlying water in two contaminated harbors. LDPE strips were also exposed in the laboratory to sediment slurries and to stagnant sediments collected at the same locations. Surprisingly short equilibration time scales (1-60 days for log K(ow) < 7) were observed for the exposures to sediment slurries. This was a result of a profound decrease in transport resistance, due to the presence of particles in the aqueous boundary layer. Concentrations in the pore water were calculated from the initial uptake rates and the dissipation rates of performance reference compounds. Good correspondence existed with concentrations estimated from the equilibrium amounts in the strips and LDPE-water partition coefficients. Sediment-water partition coefficients for PAHs were higher than for PCBs and chlorobenzenes by approximately 1 order of magnitude. A one-dimensional diffusion model was used to describe contaminant uptake by LDPE strips from stagnant sediments. The results indicated that 95% of the PAHs and 50% of the PCBs were immobile on a time scale of two months. A comparison of concentrations in pore waters and water columns indicated that a fair degree of equilibrium existed for PCBs and that one sediment was a potential source of PAHs. Concentrations of HCB near a former discharge site were higher by a factor of 6 compared to reference locations.
Macroreticular Polymeric Adsorbents (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMacroreticular Polymeric AdsorbentsD. C. KennedyCite this: Ind. Eng. Chem. Prod. Res. Dev. 1973, 12, 1, 56–61Publication Date (Print):March 1, 1973Publication History Published online1 May 2002Published inissue 1 March 1973https://pubs.acs.org/doi/10.1021/i360045a008https://doi.org/10.1021/i360045a008research-articleACS PublicationsRequest reuse permissionsArticle Views214Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Isolation, Identification, and Antioxidant Activity of Three Stilbene Glucosides Newly Extracted from <i>Vitis vinifera </i>Cell Cultures (1998)

Suspension cultures of Vitis vinifera L. (Vitaceae) produce many hydroxylated stilbene glucosides found in red wine. From these cells, we isolated and characterized glycosylated stilbenes, (Z)-piceatannol (3,5,3',4'-tetrahydroxystilbene) -3-O-beta-d-glucopyranoside (6) and (E)- and (Z)-resveratrol (3,5, 4'-trihydroxystilbene)-4'-O-beta-d-glucopyranoside (2 and 7, respectively), which have not previously reported to be constituents of Vitis vinifera or wine. The ability of these compounds to act as radical scavengers was investigated using 1,1 diphenyl-2-picryl-hydrazyl, a stable free radical. Antioxidant activities were assessed by their capacity to prevent Cu2+-induced lipid peroxidation in human low-density lipoprotein.
Design and Evaluation of Composite Fuselage Panels Subjected to Combined Loading Conditions (2005)

Methodologies used in industry for designing transport aircraft composite fuselage structures are discussed. Several aspects of the design methodologies are based on assumptions from metallic fuselage technology, which requires that full-scale structures be tested with the actual loading conditions to validate the designs. Composite panels that represent crown and side regions of a fuselage structure are designed by the use of this approach and tested in biaxial tension. Descriptions of the state-of-the-art test facilities used for this structural evaluation are presented. These facilities include a pressure-box test machine and a D-box test fixture in a combined loads test machine, which are part of a combined loads test system. Nonlinear analysis results for a reference shell and a stiffened composite panel tested in the pressure-box test machine with and without damage are presented. The analytical and test results are compared to assess the ability of the pressure-box test machine to simulate a shell stress state with and without damage. A combined loads test machine for testing aircraft primary structures is described. This test machine includes a D-box test fixture to accommodate curved stiffened panels, and the design features of this test fixture are presented. Finite element analysis results for a curved panel to be tested in the D-box test fixture are also discussed.