gebhart/patrepeval huggingface dataset:
Composite Materials Based on Ultra High Molecular Polyethylene: Properties, Application Prospects (2010)

Results are presented concerning the obtaining and properties of ultra high molecular weight polyethylene (UHMWPE) as the material withstanding severe operation conditions, unlike usual polymer modifications. It was demonstrated that modifying UHMWPE via introducing ultra fine particles of inorganic materials promotes an increase in operational performance of ware made of UHMWPE. The results of research in the field of developing the technologies for obtaining ware made of composite materials based on modified UHMWPE are generalized. Novel rubber/polymeric materials were obtained based on modified UHMWPE, butadiene-nitrile, cis-izoprene and divinyl rubbers. Owing to record breaking low abradability and due to increased operation resource under extreme service conditions concerning the ware made of the materials developed, the composite materials obtained could find wide application in various areas of engineering.
Religious coping, stress, and depressive symptoms among adolescents: A prospective study. (2011)

This study examined prospective associations between religious coping, stress, and depressive symptoms in a community sample of 111 adolescents (80 female). We hypothesized that religious coping would moderate the relationship between stress and depressive symptoms, with negative religious coping exacerbating the effects of stress on depressive symptoms and positive religious coping buffering the effects of stress on depressive symptoms. We further expected that the moderating effects of religious coping on outcomes would be strongest for youth with high personal religious commitment. Study hypotheses were tested in a prospective 12-week study. Youth selfreported their use of positive and negative religious coping strategies and personal religious commitment at baseline and then reported stressors and depressive symptoms weekly for eight weeks with an additional assessment at 12 weeks. Data were analyzed using hierarchical linear modeling. Results indicated that, as expected, negative religious coping significantly moderated the effects of stress on depressive symptoms across the 12-week study, with depressive symptoms being highest among youth with high stress exposure and high negative religious coping. The exacerbating effects of negative religious coping on the stress-depression relationship were strongest for youth with high personal religious commitment. Positive religious coping only marginally buffered the effects of stress on depressive symptoms. The results confirm and extend previous findings on the association between religious coping strategies and stress in predicting depressive symptoms.
Electron Transfer from a Polythiophene Derivative to Compounds I and II of Peroxidases (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron Transfer from a Polythiophene Derivative to Compounds I and II of PeroxidasesTetsu. Tatsuma, Kaoru. Ariyama, and Noboru. OyamaCite this: Anal. Chem. 1995, 67, 2, 283–287Publication Date (Print):January 15, 1995Publication History Published online1 May 2002Published inissue 15 January 1995https://pubs.acs.org/doi/10.1021/ac00098a008https://doi.org/10.1021/ac00098a008research-articleACS PublicationsRequest reuse permissionsArticle Views83Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Aurora-B Phosphorylation in Vitro Identifies a Residue of Survivin That Is Essential for Its Localization and Binding to Inner Centromere Protein (INCENP) in Vivo (2004)

The chromosomal passengers, aurora-B kinase, inner centromere protein (INCENP), and survivin, are essential proteins that have been implicated in the regulation of metaphase chromosome alignment, spindle checkpoint function, and cytokinesis. All three share a common pattern of localization, and it was recently demonstrated that aurora-B, INCENP, and survivin are present in a complex in Xenopus eggs and Saccharomyces cerevisiae. The presence of aurora-B kinase in the complex and its ability to bind the other components directly suggest that INCENP and survivin could potentially be aurora-B substrates. This hypothesis was recently proven for INCENP in vitro. Here we report that human survivin is specifically phosphorylated in vitro by aurora-B kinase at threonine 117 in its carboxyl alpha-helical coil. Mutation of threonine 117 to alanine prevents survivin phosphorylation by aurora-B in vitro but does not alter its localization in HeLa cells. By contrast, a phospho-mimic, in which threonine 117 was mutated to glutamic acid, was unable to localize correctly at any stage in mitosis. Mutation at threonine 117 also prevented immunoprecipitation of INCENP with survivin in vivo. These data suggest that phosphorylation of survivin at threonine 117 by aurora-B may regulate targeting of survivin, and possibly the entire passenger complex, in mammals.
A 3mpixel ROIC with 10μm pixel pitch and 120Hz frame rate digital output (2013)

A 1920x1536 matrix ROIC (Readout IC) for 10x10 μm<sup>2</sup> P-on-N InSb photodiode array is reported. The ROIC features several conversion gain options implemented at the pixel level. A 2-by-2 pixel binning feature is implemented at the pixel level as well, improving SNR and enabling higher frame rates by a factor of four. A new column ADC is designed for low noise and low power consumption, while reaching 95 kSps sampling rate. Since 3840 column ADCs are integrated on chip, the total conversion rate is over 360Mpxl/sec. The ROIC achieves 120 Hz frame rate at the full format, with power consumption of less than 400mW. A high speed digital video interface is developed to output the required data bandwidth at a reasonable pin count.
Bags of Strokes Based Approach for Classification and Indexing of Drop Caps (2011)

This paper proposes an approach to process drop cap images - images of decorated letter that begin chapters of old documents that are preserved in libraries, museums - in the domain of characterization, classification and indexing of old documents. The originality of our proposal is based on the fact that we do not try to extract the letter of drop caps but to classify the drop caps according to period, author and style. The drop caps are characterized by using relevant visual features such as length, thickness, orientation, complexity and change of direction on their primitive elements: strokes. The purpose of this approach is to efficiently extract information embedded in the drop caps for the classification and the indexing of old documents. These new visual features based on bags of strokes are more easily calculable and generally applicable than texture or shape features. Experiments based on characterization, classification and indexing phases demonstrate the performance of our propositions and the advances that they represent in terms of content-based drop caps retrieval.
Temporal Moments Analysis of Transport in Chemically Heterogeneous Porous Media (1998)

Temporal moments analysis is used to study the impact of chemical heterogeneity on the one-dimensional transport of a pollutant that undergoes linear kinetic adsorption. We make an important simplifying assumption by considering that the aquifer is physically homogeneous, but chemically heterogeneous. The aquifer is assumed to be comprised of distinct reactive and nonreactive zones; in the reactive zones the pollutant undergoes linear kinetic adsorption. The distribution of reactive sites along the porous medium is characterized using two different approaches, stochastic and deterministic. A Bernoulli random process is used in the first approach, whereas a Fourier series is used in the second. In the stochastic approach the adsorption rate constant is also allowed to vary randomly. An approximate analytical solution for the temporal moments of the stochastic problem and an exact solution for the periodic problem are obtained. Temporal moments derived from this analysis are used to compute effective parameters (velocity and dispersion) as a function of the distance from the initial contaminant injection. Our results show that the overall effective dispersion coefficient is a sum of three terms accounting for the processes of equilibrium adsorption, kinetic adsorption, and chemical heterogeneity, respectively. We examine the impact of the adsorption rate parameter upon overall spreading and show that the magnitude of this rate parameter governs the relative contribution of chemical heterogeneity. A comparison between the effective parameters for the stochastic and periodic problem and the sensitivity of the results to physical and chemical parameters are also addressed.
Short-channel effects in SOI MOSFETs (1989)

Short-channel effects in thin-film silicon-on-insulator (SOI) MOSFETs are shown to be unique because of dependences on film thickness and body and back-gate (substrate) biases. These dependences enable control of threshold-voltage reduction, channel-charge enhancement due to a drain bias, carrier velocity saturation, channel-length modulation and its effect on output conductance, as well as device degradation due to hot carriers in short-channel SOI MOSFETs. A short-channel effect exclusive to SOI MOSFETs, back-surface charge modulation, is described. Because of the short-channel effects, the use of SOI MOSFETs in VLSI circuits provides the designer with additional flexibility as compared to bulk-MOSFET design. Various design tradeoffs are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Maize CRINKLY4 Receptor Kinase Controls a Cell-Autonomous Differentiation Response (2001)

The maize (Zea mays) CRINKLY4 (cr4) gene encodes a receptor-like kinase that controls a variety of cell differentiation responses, particularly in the leaf epidermis and in the aleurone of the endosperm. In situ hybridization indicated that the cr4 transcript is present throughout the shoot apical meristem and young leaf primordia. A genetic mosaic analysis was conducted to test whether CR4 signal transduction directly regulated the cellular processes associated with differentiation or whether differentiation was controlled through the production of a secondary signal. Genetic mosaics were created using gamma-rays to induce chromosome breakage in a cr4/Cr4+ heterozygote. The mutant cr4 allele was marked with the albino mutation, Oy-700. Breakage and loss of the chromosome arm carrying the wild-type alleles created a sector of albino, cr4 mutant tissue in an otherwise normal leaf. Analysis of such sectors indicated that cr4 functions cell autonomously to regulate cell morphogenesis, implying that CR4 signal transduction regulates cell differentiation through strictly intracellular functions and not the production of secondary intercellular signals. However, several sectors altered cell patterning in wild-type tissue adjacent to the sectors, suggesting that cr4 mutant cells are defective in the production of other lateral signals.
Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy (2015)

Globoid cell leukodystrophy (GLD) is a demyelinating lysosomal storage disease due to the deficiency of the galactocerebrosidase (GALC) enzyme. The favorable outcome of hematopoietic stem and progenitor cell (HSPC)-based approaches in GLD and other similar diseases suggests HSPC gene therapy as a promising therapeutic option for patients. The path to clinical development of this strategy was hampered by a selective toxicity of the overexpressed GALC in the HSPC compartment. Here, we presented the optimization of a lentiviral vector (LV) in which miR-126 regulation was coupled to codon optimization of the human GALC cDNA to obtain a selective and enhanced enzymatic activity only upon transduced HSPCs differentiation. The safety of human GALC overexpression driven by this LV was extensively demonstrated in vitro and in vivo on human HSPCs from healthy donors. No perturbation in the content of proapoptotic sphingolipids, gene expression profile, and capability of engraftment and mutlilineage differentiation in chimeric mice was observed. The therapeutic potential of this LV was then assessed in a severe GLD murine model that benefited from transplantation of corrected HSPCs with longer survival and ameliorated phenotype as compared to untreated siblings. This construct has thus been selected as a candidate for clinical translation.
Adaptive Variation of the Transfer Unit in a Storage Hierarchy (1978)

Consider a paged storage hierarchy with at least two levels L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> and L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> , where L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> denotes main storage and L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> secondary storage. Suppose that the unit of replacement for L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> is a single page, and that the L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> -to-L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> transfer unit, given a page fault, is an integer number of pages. Then, given a suitable replacement policy for L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> , increasing the unit of transfer often results in a lower miss ratio at the expense of increased paging traffic. This paper explores the possibility of adaptively varying the L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> -to-L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> transfer unit as a function of the reference history of the data to be fetched. Experiments on traces drawn from two large data base systems suggest that such adaptation can result in improved tradeoffs between miss ratios and paging traffic.
Pneumococcal disease in a medium-sized community in the United States (1982)

To assess the importance of bacteremic pneumococcal disease among the population of one "average" American community, we studied all hospitalized patients who had<i>Streptococcus pneumoniae</i>isolated from blood, CSF, pleural fluid, or ascitic fluid during the years 1978 through 1981 in Huntington, WVa, and environs. Seventeen patients were children younger than 13 years, and 71 were adults. The case fatality rate from bacteremic pneumococcal disease among adults was 30%, and among children it was 6%. It was much higher (88%) in adults older than 50 years with extrapulmonary disease. Approximately four fifths of the typed isolates from adults or children were types included in the current vaccine. Eighty-nine percent of the adults who died of pneumococcal infection had been candidates for pneumococcal vaccine, but only one patient had received vaccine, just before becoming ill with pneumococcal disease. These data provide a basis for widespread use of pneumococcal vaccine in high-risk groups. (<i>JAMA</i>1982;248:1486-1489)
Comparison of the technical and clinical performance of the Elecsys® HBsAg II assay with the Architect®, AxSym®, and Advia® Centaur HBsAg screening assays (2010)

South East Asia has some of the highest prevalence rates of hepatitis B virus (HBV) infection (>or=8%) in the world, and the emergence of hepatitis B surface antigen (HBsAg) mutant strains is a growing problem. Assays with the highest levels of sensitivity, including mutant detection, should be used for routine HBsAg screening. In this large multicenter study, the clinical and technical performance of the fully automated Elecsys HBsAg II assay was compared with the Architect, AxSYM, and Advia Centaur HBsAg assays for HBsAg screening. Nine laboratories (three each from Thailand, Korea, and Singapore) compared the Elecsys HBsAg II assay with their routine HBsAg screening assay against a range of stored and routine clinical samples, including recombinant mutants. The Elecsys HBsAg II assay demonstrated equivalent sensitivity and specificity to the Architect HBsAg assay. However, the Elecsys HBsAg II assay recognized a native mutant sample (L94S, L97V, L98V, T123A) that the Architect HBsAg assay failed to detect. The AxSYM and Advia Centaur HBsAg assays appeared less sensitive for the detection of early HBV infection and also failed to detect some of the recombinant mutant strains. There was almost complete agreement between the Elecsys HBsAg II assay and comparator assays with respect to routine serum samples. The results of this study demonstrate that the Elecsys HBsAg II assay is a highly sensitive and specific screening assay for HBsAg and detects reliably the most important and clinically relevant HBV mutants and genotypes. It is suitable for routine HBsAg screening in Asia.
Crankshaft Torsional and Damping Simulation - An Update and Correlation with Test Results (1986)

<div class="htmlview paragraph">In recent years, interests in crankshaft analysis are renewed due to crankshaft difficulties in nuclear standby engine generator sets and elsewhere. Difficulties are caused by either deficiency in analysis procedure or in the nature of the fast-start application, or both. The continuous upgrading of the engine rating is another factor. Several advanced torsional calculation methods were developed in the U.S. to cope with this crankshaft crisis. These new methods were needed as neither the classical Holzer-Forced Vibration method nor the conventional classification rules seem rigid enough to determine the magnitude of the safety margin. These obsolete methods are not capable of pinpointing where the failures would be.</div> <div class="htmlview paragraph">Since 1983, PEI Consultants has been working actively in developing advanced torsional computer codes to simulate more closely what is actually happening in a shaft system. Several simulation codes were developed for the torsional and damping behaviors of an operating engine-generator system. This paper describes the mathematical derivation of the new codes and its good check with experimental results.</div> <div class="htmlview paragraph">In addition to crankshaft torsional and damper simulation, the potential use of torsional response for engine combustion diagnosis is also revised. This paper, 861226-A, is a revised version of that presented in the September, 1986, Milwaukee meeting.</div>
Otosclerotic Stapes: Morphological and Microchemical Correlates (1977)

A total of 32 otosclerotic stapes is thin-sectioned without decalcification and examined using transmission and scanning electron microscopes, with a nondispersive x-ray analyzer attached to the latter. These otosclerotic stapes are classified as spongiotic, sclerotic, or preotosclerotic, according to their pathologic characteristics and state of mineralization. Either diffuse or patchy demineralization in the ground substance appears to be the initial stage of otosclerosis, and this area coincides with preotosclerotic lesions (also known as blue mantle) in light microscopy. Therefore, it is interpreted that demineralization precedes the destruction of ground substance in the preotosclerotic lesion. Bone mineral deposits in new otosclerotic bone appear to be related to the collagen fibrils that are embedded in the ground substance. No mineral deposit could be seen without the ground substance deposition; therefore, it is suggested that this ground substance is the single most important factor in the poor mineralization of the otosclerosis. The sclerotic lesions are well mineralized and show a typical pattern of hydroxyapatite by x-ray diffraction study. We could not confirm the notion that the sclerotic lesion is hypermineralized as compared to the normal stapes. The spongiotic lesions are poorly mineralized, with low calcium salt. Using the Ca/P ratio and x-ray diffraction pattern as criteria, it was determined that spongiotic lesions belong to unstable, immature bone.
Association of Insulin Receptor Substrate 1 with Simian Virus 40 Large T Antigen (1995)

Mouse embryo cells expressing a wild-type number of insulin-like growth factor I receptors (IGF-IR) (W cells) can be transformed either by simian virus 40 large T antigen (SV40 T) or by overexpressed insulin receptor substrate 1 (IRS-1), singly transfected. Neither SV40 T antigen nor IRS-1, individually, can transform mouse embryo cells with a targeted disruption of the IGF-IR genes (R- cells). However, cotransfection of SV40 T antigen and IRS-1 does transform R- cells. In this study, using different antibodies and different cell lines, we found that SV40 T antigen and IRS-1 are coprecipitated from cell lysates in a specific fashion, regardless of whether the lysates are immunoprecipitated with an antibody to SV40 T antigen or an antibody to IRS-1. The same antibody to SV40 T antigen, however, fails to coprecipitate another substrate of IGF-IR, the transforming protein Shc, and two other signal-transducing molecules, Grb2 and Sos. Finally, an SV40 T antigen lacking the amino-terminal 250 amino acids fails to coprecipitate IRS-1 and also fails to transform R- cells overexpressing mouse IRS-1. These experiments indicate that IRS-1 associates with SV40 T antigen and that this association plays a critical role in the combined ability of these proteins to transform R- cells. This finding is discussed in light of the crucial role of the IGF-IR in the establishment and maintenance of the transformed phenotype.
A decision support tool to optimize scheduling of IT changes (2007)

Change management is one of the most critical processes in IT management. Some of the reasons are the sheer number of changes and the difficulty of evaluating the impact of changes on the IT services being provided. Through carrying out a survey with IT managers and practitioners, we have found that, among the activities performed during change management, change scheduling (allocating changes to change windows) is the most problematic one. In this paper we solve the change scheduling problem by using a business-driven approach that evaluates the impact of a change schedule in terms of the financial loss imposed on the service provider. Toward this aim, we model the impact of SLA violations when the implementation of changes is done after their deadline. A change scheduling optimization problem is then formalized and its solution is applied to a typical scenario. The results show that optimizing the scheduling of changes can result in significant savings to an IT support organization.