gebhart/patrepeval huggingface dataset:
ApoB/apoA-I ratio: an independent predictor of insulin resistance in US non-diabetic subjects (2007)

In the US population, apoB/apoAI ratio is significantly associated with insulin resistance in non-diabetic subjects, independently of the traditional risk factors, metabolic syndrome components, and inflammatory risk factors. Important clinical risk information provided by apoB/apoAI ratio should be recognized and implemented in future clinical guidelines.
Adaptive overrelaxed bound optimization methods (2003)

We study a class of overrelaxed bound optimization algorithms, and their relationship to standard bound optimizers, such as Expectation-Maximization, Iterative Scaling, CCCP and Non-Negative Matrix Factorization. We provide a theoretical analysis of the convergence properties of these optimizers and identify analytic conditions under which they are expected to outperform the standard versions. Based on this analysis, we propose a novel, simple adaptive overrelaxed scheme for practical optimization and report empirical results on several synthetic and real-world data sets showing that these new adaptive methods exhibit superior performance (in certain cases by several times speedup) compared to their traditional counterparts. Our extensions are simple to implement, apply to a wide variety of algorithms, almost always give a substantial speedup, and do not require any theoretical analysis of the underlying algorithm. 1.
MUC4 expression in non-small cell lung carcinomas: relationship to tumor histology and patient survival. (2007)

MUC4 expression is common in pulmonary adenocarcinomas and may indicate a more favorable prognosis in early-stage adenocarcinomas.
Serum amyloid A-containing human high density lipoprotein 3. Density, size, and apolipoprotein composition. (1986)

Serum amyloid A protein (apo-SAA), an acute phase reactant, is an apolipoprotein of high density lipoproteins (HDL), in particular the denser subpopulation HDL3. The structure of HDL3 isolated from humans affected by a variety of severe disease states was investigated with respect to density, size, and apolipoprotein composition, using density gradient ultracentrifugation, gradient gel electrophoresis, gel filtration, and solid phase immunoadsorption. Apo-SAA was present in HDL particles in increasing amounts as particle density increased. Apo-SAA-containing HDL3 had bigger radii than normal HDL3 of comparable density. Purified apo-SAA associated readily with normal HDL3 in vitro, giving rise to particles containing up to 80% of their apoproteins as apo-SAA. The addition of apo-SAA resulted in a displacement of apo-A-I and an increase in particle size. Acute phase HDL3 represented a mixture of particles, polydisperse with respect to apolipoprotein content; for example, some particles were isolated that contained apo-A-I, apo-A-II, and apo-SAA, whereas others contained apo-A-I and apo-SAA but no apo-A-II. We conclude that apo-SAA probably associates in the circulation of acute phase patients with existing HDL particles, causing the remodeling of the HDL shell to yield particles of bigger size and higher density that are relatively depleted of apo-A-I.
Infrared reflectance spectroscopy for estimation of moisture of whole grain (1977)

IR reflectance readings measured with a tilting-filter wheel instrument were compared with oven moisture analyses of maize and sorghum grain. Correlation coefficients were 0.993 for maize and 0.959 for sorghum samples ranging in m.c. from 13 to 55%. It was concluded that the IR method showed promise for rapid estimation of m.c. in high-moisture whole grains, and modifications in instrumentation were suggested
Nitrogen Induction of Sugar Catabolic Gene Expression in Synechocystis sp. PCC 6803 (2006)

Nitrogen starvation requires cells to change their transcriptome in order to cope with this essential nutrient limitation. Here, using microarray analysis, we investigated changes in transcript profiles following nitrogen depletion in the unicellular cyanobacterium Synechocystis sp. PCC 6803. Results revealed that genes for sugar catabolic pathways including glycolysis, oxidative pentose phosphate (OPP) pathway, and glycogen catabolism were induced by nitrogen depletion, and activities of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD), two key enzymes of the OPP pathway, were demonstrated to increase under this condition. We recently showed that a group 2 sigma factor SigE, which is under the control of the global nitrogen regulator NtcA, positively regulated these sugar catabolic pathways. However, increases of transcript levels of these sugar catabolic genes under nitrogen starvation were still observed even in a sigE-deficient mutant, indicating the involvement of other regulatory element(s) in addition to SigE. Since these nitrogen activations were abolished in an ntcA mutant, and since these genes were not directly included in the NtcA regulon, we suggested that sugar catabolic genes were induced by nitrogen depletion under complex and redundant regulations including SigE and other unknown factor(s) under the control of NtcA.
Towards a framework for handling disputes in payment systems (1998)

The ability to support disputes is an important, but often neglected aspect of payment systems. In dealing with dispute support, the first step is to define how to express various dispute claims. In this report, we present a language for expressing dispute claims in a unified manner, independent of any specific payment system. We illustrate how to support claims made in this systemindependent language with evidence tokens from an example payment system. We describe an architecture for handling disputes, and present a design for incorporating dispute handling support into SEMPER [Wai96]. Our approach may be generalised to other services where accountability is a requirement. 1 Introduction 1.1 Importance of Disputes in Electronic Commerce Services in an electronic commerce system involve more than one player. An effective system guarantees that if all players behave correctly (&quot;honestly&quot;) according to some pre-defined protocol, each player obtains the services it expects. A system w...
Microwave Tissue Ablation: Biophysics, Technology, and Applications (2010)

Microwave ablation is an emerging treatment option for many cancers, cardiac arrhythmias, and other medical conditions. During treatment, microwaves are applied directly to tissues to produce rapid temperature elevations sufficient to produce immediate coagulative necrosis. The engineering design criteria for each application differ, with individual consideration for factors such as desired ablation zone size, treatment duration, and procedural invasiveness. Recent technological developments in applicator cooling, power control, and system optimization for specific applications promise to increase the utilization of microwave ablation in the future. This article reviews the basic biophysics of microwave tissue heating, provides an overview of the design and operation of current equipment, and outlines areas for future research.
Demonstration of a novel optical transmitter for high-speed differential phase-shift-keying/inverse-return-to-zero (DPSK/inv-RZ) orthogonally modulated signals (2005)

We propose and experimentally demonstrate a simple and novel optical transmitter for superimposing 10-Gb/s differential phase-shift-keying signals on a 10-Gb/s inverse-return-to-zero signal. The proposed transmitter comprises a dual-drive Mach-Zehnder intensity modulator and an optical phase modulator. Its performance has been experimentally characterized.
Clinical Evaluation of Efficacy and Tolerability of HMC05 in Healthy Subjects with Normal and High-Normal Blood Pressure: A Pilot Study (2010)

HMC05, a formulation containing eight different herbal extracts, has been used widely for several thousand years in China, Japan, and Korea as a remedy for hypertension and headache. Although its anti-inflammatory effects in mouse monocytic cell lines and anti-atherosclerotic effects in apoE-knockout mice have been reported, the pharmacodynamic effects of HMC05 in human subjects have not yet been investigated. We evaluated the efficacy and tolerability of this drug in 14 healthy male Korean subjects with normal or high-normal blood pressure (BP) in a randomized, single-blind, crossover study with a 2-week washout period. Four 500-mg tablets of HMC05 or placebo were orally administered three times daily to nine subjects with normal BP and five subjects with high-normal BP for 4 weeks. To assess the pharmacodynamic effects of HMC05, levels of high-sensitivity C-reactive protein and homocysteine, BP, and flow-mediated vasodilation were measured before and after the 4-week medication period with evaluation of tolerability. All 14 subjects completed the study, and HMC05 was well tolerated with no significant adverse events. HMC05 did not exhibit a significant BP-lowering effect in either BP group, and there were no significant differences in other pharmacodynamic values after HMC05 or placebo administration in the two groups. Further study is needed to evaluate the efficacy and tolerability of HMC05 in an adequate number of patients with hypertension.
Management of acute myocardial infarction in patients presenting with ST-segment elevation (2003)

The management of acute myocardial infarction continues to undergo major changes. Good practice should be based on sound evidence derived from well-conducted clinical trials. Because of the great number of trials on new treatments performed in recent years and because of new diagnostic tests, the European Society of Cardiology decided that it was opportune to upgrade the 1996 guidelines and appointed a Task …
Automatic signature verification using a three-axis force-sensitive pen (1983)

A performance analysis of an automatic signature-verification system based upon the use of a three-axis force-sensitive pen to transduce the dynamics of the handwritten signature into electrical signals suitable for real-time computer processing is presented. False-rejection and imposter-acceptance (i.e. type I/type II error) curves are presented for a variety of operating conditions. For typical `real world' conditions, the equal-error rate (where type I error rate equals type II error rate) is about one percent. The performance analysis was based upon a data base of 5220 true signatures obtained from 58 subjects over a four- month period, and 648 attempted forgeries obtained from 12 forgers. The forgers were given copies of the true signers' signatures, told how the verification system operates and what it measures, allowed to watch video tapes with close-up views of the signatures to be forged as they were being written, and allowed to practice for a three-week period. Particular advantages of the signature-verification system reported here are high performance, low storage requirements (typically 200 to 300 bits per user), and low-cost implementation in a stand-alone microprocessor unit.
Different Roles of EIIAB <sup>Man</sup> and EII <sup>Glc</sup> in Regulation of Energy Metabolism, Biofilm Development, and Competence in <i>Streptococcus mutans</i> (2006)

The phosphoenolpyruvate:sugar phosphotransferase system (PTS) is the major carbohydrate transport system in oral streptococci. The mannose-PTS of Streptococcus mutans, which transports mannose and glucose, is involved in carbon catabolite repression (CCR) and regulates the expression of known virulence genes. In this study, we investigated the role of EII(Glc) and EIIAB(Man) in sugar metabolism, gene regulation, biofilm formation, and competence. The results demonstrate that the inactivation of ptsG, encoding a putative EII(Glc), did not lead to major changes in sugar metabolism or affect the phenotypes of interest. However, the loss of EII(Glc) was shown to have a significant impact on the proteome and to affect the expression of a known virulence factor, fructan hydrolase (fruA). JAM1, a mutant strain lacking EIIAB(Man), had an impaired capacity to form biofilms in the presence of glucose and displayed a decreased ability to be transformed with exogenous DNA. Also, the lactose- and cellobiose-PTSs were positively and negatively regulated by EIIAB(Man), respectively. Microarrays were used to investigate the profound phenotypic changes displayed by JAM1, revealing that EIIAB(Man) of S. mutans has a key regulatory role in energy metabolism, possibly by sensing the energy levels of the cells or the carbohydrate availability and, in response, regulating the activity of transcription factors and carbohydrate transporters.
Dash or slash? Renewing the link between media and culture (2000)

Failure to visualize a kidney on radionuclide scanning using technetium-99m (99mTc) chelates and other renal radiopharmaceuticals such as iodine-131 hippuran has been described as potentially misleading in patients who have acute renal failure due to acute tubular necrosis and urinary tract obstruction. Such failure has not been described in a single kidney nor following angioplasty. The authors report a patient in whom a kidney was not visualized on 99mTc diethylenetriamine penta-acetic acid dynamic and serial scanning 3 days after renal angioplasty. The kidney was believed to be infarcted. Three months later there was almost complete recovery of renal function.
Haemodynamic and Neurohumoral Changes in Spontaneously Hypertensive Rats with Aortocaval Fistulae (1993)

1. Our aim was to evaluate the effects of an aortocaval fistula (1 mm) on cardiorenal haemodynamics, cardiac hypertrophy and neurohumoral factors in spontaneously hypertensive rats and to compare the results with those observed in Wistar rats at 2 weeks after fistulae placement. Sham-operated spontaneously hypertensive rats and Wistar rats served as controls. 2. Heart weight was significantly increased in spontaneously hypertensive rats (34%) and in Wistar rats (43%) at 2 weeks after fistula creation. Left ventricular systolic pressure and dp/dtmax. were significantly decreased (both P < 0.01) in spontaneously hypertensive rats with fistulae which had higher left ventricular end-diastolic pressure than Wistar rats with fistulae (P < 0.01). Signs of circulatory congestion (ascites, tachypnoea, prostration) were observed only in the overloaded spontaneously hypertensive rats (45%). Cardiac index was comparably increased in both fistulae groups due to an increase in stroke index, since heart rate was not increased. 3. Fistulae placement decreased renal blood flow and kidney weight, and increased blood urea nitrogen to a greater degree in spontaneously hypertensive rats (all P < 0.05); serum creatinine levels were unaltered. Plasma noradrenaline concentration was increased in spontaneously hypertensive rats with fistulae (P < 0.05), whereas plasma renin activity was not changed. 4. Thus, spontaneously hypertensive rats with fistulae developed overt haemodynamic signs of high-output heart failure with frequent ascites and dyspnoea, whereas most of these findings were milder or absent in Wistar rats. This model provides an opportunity to evaluate the pathophysiological and pharmacological responses in high-output heart failure.
Amine oxidase (1939)

Research Article| August 01 1939 Amine oxidase K. Bhagvat; K. Bhagvat 1The Biochemical and Physiological Laboratories, Cambridge, and the Central Pathological Laboratory, The Maudsley Hospital, London Search for other works by this author on: This Site PubMed Google Scholar H. Blaschko; H. Blaschko 1The Biochemical and Physiological Laboratories, Cambridge, and the Central Pathological Laboratory, The Maudsley Hospital, London Search for other works by this author on: This Site PubMed Google Scholar D. Richter D. Richter 1The Biochemical and Physiological Laboratories, Cambridge, and the Central Pathological Laboratory, The Maudsley Hospital, London Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd © 1939 CAMBRIDGE UNIVERSITY PRESS1939 Biochem J (1939) 33 (8): 1338–1341. https://doi.org/10.1042/bj0331338 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation K. Bhagvat, H. Blaschko, D. Richter; Amine oxidase. Biochem J 1 August 1939; 33 (8): 1338–1341. doi: https://doi.org/10.1042/bj0331338 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1939 CAMBRIDGE UNIVERSITY PRESS1939 Article PDF first page preview Close Modal You do not currently have access to this content.
Substrate specificity of a thymidine phosphorylase in human liver tumor. (1984)

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A Framework to Balance Privacy and Data Usability Using Data Degradation (2009)

Personal data is a valuable asset for service providers. To collect such data, free services are offered to users, for whom the risk of loosing privacy by subscribing to a service is often not clear. Although the services are free in terms of money, the user does not know how much he or she actually pays for a given service when allowing his or her data to be collected, unaware of taking a significant privacy risk by doing so. In practice, this risk is even not taken into account when deciding how long the data will be retained; the service provider simply wants to optimize the total worth of the stored data by retaining the data as long as possible. In this paper, we express the privacy risk for the user in terms of such a retention period; the user wants to optimize its privacy by allowing the data to be retained as short as possible. Now, in stead of only considering the interests of the service provider, we argue that we should optimize the common interest of both parties, and present a framework to reason about worth and privacy to find such optimum. Going one step further, we refine and generalize limited retention to data degradation, which prescribes to store data in progressively less accurate forms. Data degradation gives users and service providers a fine grained control over the price to be paid, in terms of privacy risks, and to optimize their common interest: balancing privacy and data usability.
A Stick-slip Analysis Based on Rock/Bit Interaction: Theoretical and Experimental Contribution (2000)

Abstract The purpose of this paper is to analysis bit stick-slip motion by using rock mechanics considerations coupled with field bottomhole data. The data was collected using an instrumented PDC bit. This new tool enables to measure accelerations, Weight-On-Bit (WOB) and Torque-On-Bit (TOB) directly above the bit. Tests were conducted in Montrose (Scotland) at about 700 m depth in a consolidated Devonien sandstone. During several hours of testing, the sensitivity to operating and different structural parameters was evaluated. The effect of stick-slip on Rate Of Penetration (ROP) was quantified: ROP is really affected by this dynamical phenomenon which appears above a certain Weight-On-Bit threshold. Two stages rule the drillstring behaviour. The stationary behaviour (small oscillation of the rotation bit speed around the mean value) is described by modal analysis. Experimental frequencies are in agreement with the theoretical natural ones. A perturbation of the operating parameters (generally an increasing of the WOB) makes the system bifurc towards stick-slip. The dynamical system is now governed by a non linear autonomous boundary condition, linked to the rock/bit interaction. Rock mechanics considerations justifie such a law. Numerical simulations converge on stick-slip, typical limit cycle experimentally exhibited. The last analysis is focused on an analysis of "drill-off test". In this operating stage, the rock/bit interaction function changes. Numerical simulations, justified by clearly experimental evidence, show the benefit effect of such a test, which stabilizes the system. A discussion on the effect of the stabilizers and bit type follows as well as how to attenuate this non linear phenomenon.
Wired: Wire-aware Circuit Description (2005)

As we strive towards higher abstraction levels, the designer can lose control over low-level details, which eventually turn out to have significant impact on circuit performance. In particular, it is the routing wires that dominate the non-functional properties of circuits in deep sub-micron technologies. In the proposed system, called Wired, the designer can express circuit function together with detailed placement of cells and wires, in order to get more precise control over the result. The system allows direct analysis of non-functional properties, and in fact, the result of such analyses can be used to guide instantiation decisions. Case studies show that common structures, such as parallel prefix computations, and even non-trivial versions, are described efficiently in Wired.
ERK Signaling Pathways Regulate the Osteogenic Differentiation of Human Mesenchymal Stem Cells on Collagen I and Vitronectin (2004)

Adhesion to the extracellular matrix (ECM) proteins collagen I and vitronectin is sufficient to drive human mesenchymal stem cells (hMSCs) into an osteogenic differentiation pathway, but the mechanisms underlying this stimulation are not well understood. We found that addition of beta1 and alpha(v)beta3 integrin blocking antibodies inhibited ECM-induced ERK activation, while addition of the MEK inhibitor PD98059 blocked ERK activation, serine phosphorylation of the osteogenic transcription factor runx2/cbfa-1, osteogenic gene expression, and calcium deposition. These results suggest that ERK plays an important role in driving the ECM-induced osteogenic differentiation of hMSC.
The social camera (2011)

The digital camera revolution has changed the world of photography and now most people have access to, and even regularly carry, a digital camera. Often these cameras have been designed with simplicity in mind: they harness a variety of sophisticated technologies in order to automatically take care of all manner of complex settings (aperture, shutter speed, flash etc.) for point-and-shoot ease, these assistive features are usually incorporated directly into the cameras interface. However, there is little or no support for the end-user when it comes to helping them to compose or frame a scene. To this end we describe a novel recommendation process which uses a variety of intelligent and assistive interfaces to guide the user in taking relevant compositions given their current location and scene context. This application has been implemented on the Android platform and we describe its core user interaction, recommendation technologies and demonstrate its effectiveness in a number of real-world scenarios. Specifically we report on the results of a live-user trial of the technology in a real-world tourist setting.
Real-time programmable image subtraction using a magnetooptic device (1985)

In an effort to combine the advantages of optical information processing and the flexibility of digital computers, a real-time image subtraction system has been developed. This system uses a microcomputer to control a Litton magnetooptic device and as an interface to a video camera. Since the magnetooptic device is a transmitted type spatial light modulator, it can perform real-time programmable optical signal processing. Details of the system and its performance used in image subtraction are discussed. Additionally, experimental demonstrations of the subtracted images are shown. A brief discussion of the possible use of the system in applications such as robotics vision and automated inspection is also presented.