gebhart/patrepeval huggingface dataset:
Nucleic Acid Related Compounds. 87. Nucleophilic Functionalization of Cytidine and 2'-Deoxycytidine Derivatives via Elaboration of the 4-Amino Group into a Readily Displaced 1,2,4-Triazol-4-yl Substituent (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleic Acid Related Compounds. 87. Nucleophilic Functionalization of Cytidine and 2'-Deoxycytidine Derivatives via Elaboration of the 4-Amino Group into a Readily Displaced 1,2,4-Triazol-4-yl SubstituentRobert W. Miles, Vicente Samano, and Morris J. RobinsCite this: J. Org. Chem. 1995, 60, 21, 7066–7069Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/jo00126a078https://doi.org/10.1021/jo00126a078research-articleACS PublicationsRequest reuse permissionsArticle Views263Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Slug Regulates Integrin Expression and Cell Proliferation in Human Epidermal Keratinocytes (2006)

The human epidermis is a self-renewing epithelial tissue composed of several layers of keratinocytes. Within the epidermis there exists a complex array of cell adhesion structures, and many of the cellular events within the epidermis (differentiation, proliferation, and migration) require that these adhesion structures be remodeled. The link between cell adhesion, proliferation, and differentiation within the epidermis is well established, and in particular, there is strong evidence to link the process of terminal differentiation to integrin adhesion molecule expression and function. In this paper, we have analyzed the role of a transcriptional repressor called Slug in the regulation of adhesion molecule expression and function in epidermal keratinocytes. We report that activation of Slug, which is expressed predominantly in the basal layer of the epidermis, results in down-regulation of a number of cell adhesion molecules, including E-cadherin, and several integrins, including alpha3, beta1, and beta4. We demonstrate that Slug binds to the alpha3 promoter and that repression of alpha3 transcription by Slug is dependent on an E-box sequence within the promoter. This reduction in integrin expression is reflected in decreased cell adhesion to fibronectin and laminin-5. Despite the reduction in integrin expression and function, we do not observe any increase in differentiation. We do, however, find that activation of Slug results in a significant reduction in keratinocyte proliferation.
Stem cell‐based cell therapy for Huntington disease: A review (2007)

Huntington disease (HD) is a devastating neurodegenerative disorder and no proven medical therapy is currently available to mitigate its clinical manifestations. Although fetal neural transplantation has been tried in both preclinical and clinical investigations, the efficacy is not satisfactory. With the recent explosive progress of stem cell biology, application of stem cell-based therapy in HD is an exciting prospect. Three kinds of stem cells, embryonic stem cells, bone marrow mesenchymal stem cells and neural stem cells, have previously been utilized in cell therapy in animal models of neurological disorders. However, neural stem cells were preferably used by investigators in experimental HD studies, since they have a clear capacity to become neurons or glial cells after intracerebral or intravenous transplantation, and they induce functional recovery. In this review, we summarize the current state of cell therapy utilizing stem cells in experimental HD animal models, and discuss the future considerations for developing new therapeutic strategies using neural stem cells.
Regulation of NF-κB RelA Phosphorylation and Transcriptional Activity by p21 and Protein Kinase Cζ in Primary Endothelial Cells (1999)

The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation.
Visual exposure to large and small portion sizes and perceptions of portion size normality: Three experimental studies (2015)

Portion sizes of many foods have increased in recent times. In three studies we examined the effect that repeated visual exposure to larger versus smaller food portion sizes has on perceptions of what constitutes a normal-sized food portion and measures of portion size selection. In studies 1 and 2 participants were visually exposed to images of large or small portions of spaghetti bolognese, before making evaluations about an image of an intermediate sized portion of the same food. In study 3 participants were exposed to images of large or small portions of a snack food before selecting a portion size of snack food to consume. Across the three studies, visual exposure to larger as opposed to smaller portion sizes resulted in participants considering a normal portion of food to be larger than a reference intermediate sized portion. In studies 1 and 2 visual exposure to larger portion sizes also increased the size of self-reported ideal meal size. In study 3 visual exposure to larger portion sizes of a snack food did not affect how much of that food participants subsequently served themselves and ate. Visual exposure to larger portion sizes may adjust visual perceptions of what constitutes a 'normal' sized portion. However, we did not find evidence that visual exposure to larger portions altered snack food intake.
The Relationship Between Diabetic Retinopathy and Diabetic Nephropathy in a Population-Based Study in Korea (KNHANES V-2, 3) (2014)

In DM patients, we observed a prevalence of 20.0% for any DR and 3.8% for proliferative diabetic retinopathy (PDR). Microalbuminuria prevalence was 19.3% and overt nephropathy prevalence was 5.5%. The risk factors of microalbuminuria were presence of hypertension; higher systolic blood pressure, serum hemoglobin A1c (HbA1c), and serum blood urea nitrogen level; as well as the presence of PDR. The risk factors of overt nephropathy were long duration of DM; high levels of HbA1c, systolic blood pressure, total cholesterol, and serum creatinine; as well as the presence of DR CONCLUSIONS: Proliferative diabetic retinopathy is associated with microalbuminuria and DR is associated with overt nephropathy in Korean DM patients. Our findings suggest that when an ophthalmologist finds the presence of DR or PDR, timely evaluation of the patient's renal status should be recommended.
Comparing degree programs using unadjusted performance indicators. Assessing the bias from the Potential Confounding Factors (2012)

The Italian central government distributes part of the university annual\nfunding on the basis of a ranking between academic institutions. The ranking is based on the values of indicators observed in each institution. From that issue it arises the demand to assess the performances of academic institutions taking into account not only the output of the educational process but also the so called input factors that\nmay act within a system as Potential Confounding Factors. The purpose of this work is to assess the role played by students’ characteristics that act as Potential Confounding Factors and to build up adjusted performance indicator.
ERNI-3D : a technology-generic tool for interconnect reliability projections in 3D integrated circuits (2001)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2001.
The Problem of Externalities (2001)

The most commonly recognized reason for markets to produce “inefficient” or non-wealth-maximizing results is “transaction costs” that prevent some costs and some benefits from being brought to bear on the actions or decision making of market participants. The consequence of this failure is often described as an externality. Pollution is a standard example of a negative externality; a beautiful landscape freely observable by the public exemplifies a positive externality. If negative impacts of an activity are not brought to bear on the decision making of the actor, the predictable result is too much of an activity. The converse is true for positive externalities; if positive effects are not brought to bear, not made into an incentive, the result is too little of the activity. Failure to bring these effects to bear can also lead the actor to behave in a less than optimal manner (e.g., to fail to install a cheap and effective pollution control device).
Selective subtraction when the scene cannot be learned (2011)

Background subtraction techniques model the background of the scene using the stationarity property and classify the scene into two classes of foreground and background. In doing so, most moving objects become foreground indiscriminately, except for perhaps some waving tree leaves, water ripples, or a water fountain, which are typically “learned” as part of the background using a large training set of video data. We introduce a novel concept of background as the objects other than the foreground, which may include moving objects in the scene that cannot be learned from a training set because they occur only irregularly and sporadically, e.g. a walking person. We propose a “selective subtraction” method as an alternative to standard background subtraction, and show that a reference plane in a scene viewed by two cameras can be used as the decision boundary between foreground and background. In our definition, the foreground may actually occur behind a moving object. Furthermore, the reference plane can be selected in a very flexible manner, using for example the actual moving objects in the scene, if needed. We present diverse set of examples to show that: (i) the technique performs better than standard background subtraction techniques without the need for training, camera calibration, disparity map estimation, or special camera configurations; (ii) it is potentially more powerful than standard methods because of its flexibility of making it possible to select in real-time what to filter out as background, regardless of whether the object is moving or not, or whether it is a rare event or a frequent one.
Long-Term Protective and Antigen-Specific Effect of Heat-Killed <i>Mycobacterium vaccae</i> in a Murine Model of Allergic Pulmonary Inflammation (2002)

This report examines the effect of heat-killed Mycobacterium vaccae in a mouse model of allergic pulmonary inflammation. The s.c. administration of M. vaccae 3 wk before the immunization significantly reduced Ag-induced airway hyperreactivity and the increase in the numbers of eosinophils observed in the bronchoalveolar lavage fluid, blood, and bone marrow, even though no detectable changes in either cytokine (IL-4, IL-13, IL-5, and IFN-gamma) or total IgE levels were observed. Furthermore, transfer of splenocytes from OVA-immunized and M. vaccae-treated mice into recipient, OVA-immunized mice significantly reduced the allergen-induced eosinophilia by an IFN-gamma-independent mechanism, clearly indicating that the mechanism by which M. vaccae induces its inhibitory effect is not due to a redirection from a predominantly Th2 to a Th1-dominated immune response. The protective effect of M. vaccae on the allergen-induced eosinophilia lasted for at least 12 wk after its administration, and the treatment was also effective in presensitized mice. Moreover, the allergen specificity of the inhibitory effect could be demonstrated using a double-immunization protocol, where M. vaccae treatment before OVA immunization had no effect on the eosinophilic inflammation induced by later immunization and challenge with cockroach extract Ag. Taken together, these results clearly demonstrate that M. vaccae is effective in blocking allergic inflammation by a mechanism independent of IFN-gamma, induces long term and Ag-specific protection, and therefore has both prophylactic and therapeutic potential for the treatment of allergic diseases.
A combined FPAA-FPGA platform for mixed-signals design space exploration (2005)

Fast analog circuit design and rapid prototyping is increasingly required in mixed-signal designs to keep pace with the digital part in order to meet stringent time to market constraints. In order to achieve these goals heavy reliance on analog design automation and prototyping platforms is required. This paper presents an analog circuit multiobjective design methodology combined with a reconfigurable analog platform. The complete prototyping system is composed of field-programmable analog arrays (FPAAs) and Field Programmable Gate Arrays (FPGAs) on which the synthesized designs are implemented and validated in order to optimize the desired analog circuit. Compared with simulation based methodologies important gains in total design time are achieved. We applied this methodology on a case study of a rejecter filter.
A New Variant Form of Phenylketonuria (1979)

We report a family (parents and two sets of twin girls) in which the propositus presented as a case of phenylketonuria with a somewhat less severe degree of phenylalanine intolerance than occurs in patients with classical phenylketonuria and whose phenylalanine tolerance was further impaired by giving cotrimoxazole. The trimethoprim component of cotrimoxazole reduces the phenylalanine tolerance of normal subjects but does not augment the degree of phenylalanine intolerance in patients with classical phenylketonuria. The results of the present study of the phenylalanine tolerance and the way in which cotrimoxazole modifies it in the members of this family are compatible with the segregation of an abnormal gene which causes a previously unrecognized type of phenylketonuria when it is present in the homozygous state. The possible relationship of this to other inherited biochemical lesions of the phenylalanine hydroxylase system is briefly discussed.
New Targeted Treatments for Fragile X Syndrome (2019)

Fragile X Syndrome (FXS) is the most common cause of inherited intellectual disability with prevalence rates estimated to be 1:5,000 in males and 1:8,000 in females. The increase of >200 Cytosine Guanine Guanine (CGG) repeats in the 5' untranslated region of the Fragile X Mental Retardation 1 (FMR1) gene results in transcriptional silencing on the FMR1 gene with a subsequent reduction or absence of fragile X mental retardation protein (FMRP), an RNA binding protein involved in the maturation and elimination of synapses. In addition to intellectual disability, common features of FXS are behavioral problems, autism, language deficits and atypical physical features. There are still no currently approved curative therapies for FXS, and clinical management continues to focus on symptomatic treatment of comorbid behaviors and psychiatric problems. Here we discuss several treatments that target the neurobiological pathway abnormal in FXS. These medications are clinically available at present and the data suggest that these medications can be helpful for those with FXS.
Prefetching: A Survey (2011)

Current Web is a huge repository, with its explosion in both the range and quantity of web content. Even, when the speed of Internet has improved with the reduced costs, the traffic is getting heavier. The enormous information makes it difficult to find the relevant information quickly. This led to the effort to improve the speed, by reducing the latency, make the web more relevant and meaningfully connected. Prefetching is the method for reducing Latencies. This area of research gains importance since, an user always expects an interactive response, better satisfaction and quality of output. This paper presents the various issues in Prefetching.
Cytokines in Reproduction (1993)

A growing body of evidence indicates that, in addition to the hormones of hypothalamic, pituitary and gonadal origin, autocrine/paracrine regulators play important roles in the reproductive functions. Cytokines, originally known as immunoregulatory proteins, may affect the neuroendocrine events of reproduction, ovarian/testis function, endometrium, the developing embryo, placenta and parturition. Cytokines can modulate and mediate the actions of hormones at their target cells and, in the opposite way, hormones may regulate the production and action of cytokines at three different levels: cytokine secretion, cytokine receptor expression and cellular responses. Cytokines may also function in an endocrine manner affecting distant targets. As many of the cyclic changes that occur in the ovary and endometrium during the normal menstrual cycle are similar to those associated with the inflammatory and regenerative processes, it is likely that cytokines are involved in these reactions. Furthermore, cytokines secreted by endometrial white blood cells may influence embryo development and trophoblast growth and may play a fundamental role in the mechanisms of immunological reproductive failure. Cytokines have also been implicated in the mechanisms responsible for the onset of parturition.
Targeting Cancer Stem Cell Plasticity Through Modulation of Epidermal Growth Factor and Insulin-Like Growth Factor Receptor Signaling in Head and Neck Squamous Cell Cancer (2014)

Emerging data suggest that cancer stem cells (CSCs) exist in equilibrium with differentiated cells and that stochastic transitions between these states can account for tumor heterogeneity and drug resistance. The aim of this study was to establish an in vitro system that recapitulates stem cell plasticity in head and neck squamous cell cancers (HNSCCs) and identify the factors that play a role in the maintenance and repopulation of CSCs. Tumor spheres were established using patient-derived cell lines via anchorage-independent cell culture techniques. These tumor spheres were found to have higher aldehyde dehydrogenase (ALD) cell fractions and increased expression of Kruppel-like factor 4, SRY (sex determining region Y)-box 2, and Nanog and were resistant to γ-radiation, 5-fluorouracil, cisplatin, and etoposide treatment compared with monolayer culture cells. Monolayer cultures were subject to single cell cloning to generate clones with high and low ALD fractions. ALDHigh clones showed higher expression of stem cell and epithelial-mesenchymal transition markers compared with ALDLow clones. ALD fractions, representing stem cell fractions, fluctuated with serial passaging, equilibrating at a level specific to each cell line, and could be augmented by the addition of epidermal growth factor (EGF) and/or insulin. ALDHigh clones showed increased EGF receptor (EGFR) and insulin-like growth factor-1 receptor (IGF-1R) phosphorylation, with increased activation of downstream pathways compared with ALDLow clones. Importantly, blocking these pathways using specific inhibitors against EGFR and IGF-1R reduced stem cell fractions drastically. Taken together, these results show that HNSCC CSCs exhibit plasticity, with the maintenance of the stem cell fraction dependent on the EGFR and IGF-1R pathways and potentially amenable to targeted therapeutics.
Bevelling technique for low surface roughness based on CMP (2002)

Chemical-mechanical polishing (CMP) has been applied and optimised for bevelling of semiconductor heterojunctions for the first time. The optimised technique, based on the use of a glass pad, results in a dramatically decreased surface roughness. The technique is compared to mechanical bevelling. The advantage of this smooth bevel for different material characterisation techniques is discussed.
ChemInform Abstract: Preparation and Application of Inorganic Layered Compounds for Anion Exchanged Reaction (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Temporal Decision Trees: Model-based Diagnosis of Dynamic Systems On-Board (2003)

The automatic generation of decision trees based on off-line reasoning on models of a domain is a reasonable compromise between the advantages of using a model-based approach in technical domains and the constraints imposed by embedded applications. In this paper we extend the approach to deal with temporal information. We introduce a notion of temporal decision tree, which is designed to make use of relevant information as long as it is acquired, and we present an algorithm for compiling such trees from a model-based reasoning system.
Fetal lung maturity analysis using ultrasound image features (2002)

This pilot study was carried out to find the feasibility of analyzing the maturity of the fetal lung using ultrasound images. Data were collected from normal pregnant women at intervals of two weeks from the gestation age of 24 to 38 weeks. Images were acquired at two centers located at different geographical locations. The total data acquired consisted of 750 images of immature and 250 images of mature class. A region of interest of 64 x 64 pixels was used for extracting the features. Various textural features were computed from the fetal lung and liver images. The ratios of fetal lung to liver feature values were investigated as possible indexes for classifying the images into those from mature (reduced pulmonary risk) and immature (possible pulmonary risk) lung. The features used are fractal dimension, lacunarity, and features derived from the histogram of the images. The following classifiers were used to classify the fetal lung images as belonging to mature or immature lung: nearest neighbor, k-nearest neighbor, modified k-nearest neighbor, multilayer perceptron, radial basis function network, and support vector machines. The classification accuracy obtained for the testing set ranges from 73% to 96%.