gebhart/patrepeval huggingface dataset:
Molecular Genetics Molecular Genetics of Plants and Animals Kathleen Downey Richard W. Voellmy Fazal Ahmad Julius Schultz (1985)

Molecular Genetics Get access Molecular Genetics of Plants and Animals. Advances in Gene Technology, vol. 20. Proceedings of the Miami Winter Symposium, January 1983. Kathleen Downey Voellmy Richard W. Ahmad Fazal Schultz Julius, eds. Academic Press, New York, 1983. 604 pp., illus. $48.00 (cloth). John Bennett John Bennett Biology Department, Brookhaven National Laboratory, Upton, NY 11973 Search for other works by this author on: Oxford Academic Google Scholar BioScience, Volume 35, Issue 8, September 1985, Pages 509–510, https://doi.org/10.2307/1309820 Published: 01 September 1985
VCSEL polarization control by optical injection (2003)

The stability of the polarization-resolved (PR) light output of a commercial vertical-cavity surface-emitting laser (VCSEL) has been studied with and without the presence of external optical injection in a master-slave configuration. Pulsations in the PR light output are observed in the solitary laser at certain bias current. It has been observed here for the first time that optical injection can stabilize the polarization of a VCSEL operating in a pulsation regime.
On training the recurrent neural network encoder-decoder for large vocabulary end-to-end speech recognition (2016)

Recently, there has been an increasing interest in end-to-end speech recognition using neural networks, with no reliance on hidden Markov models (HMMs) for sequence modelling as in the standard hybrid framework. The recurrent neural network (RNN) encoderdecoder is such a model, performing sequence to sequence mapping without any predefined alignment. This model first transforms the input sequence into a fixed length vector representation, from which the decoder recovers the output sequence. In this paper, we extend our previous work on this model for large vocabulary end-to-end speech recognition. We first present a more effective stochastic gradient decent (SGD) learning rate schedule that can significantly improve the recognition accuracy. We then extend the decoder with long memory by introducing another recurrent layer that performs implicit language modelling. Finally, we demonstrate that using multiple recurrent layers in the encoder can reduce the word error rate. Our experiments were carried out on the Switchboard corpus using a training set of around 300 hours of transcribed audio data, and we have achieved significantly higher recognition accuracy, thereby reduced the gap compared to the hybrid baseline.
High-Q nanocavity with a 2-ns photon lifetime (2007)

We have succeeded in fabricating a photonic crystal nanocavity with a photon lifetime of 2.1 ns, which corresponds to a quality factor of 2.5 x 10(6). This lifetime is the longest recorded thus far in photonic crystal cavities, and was brought about by improvements in the fabrication process. Comparing our experimental quality factor with the results of calculations shows that we have suppressed variations in the radii and positions of the air holes composing a nanocavity such that their standard deviations are less than 1 nm.
Traveling-wave analysis of a bifilar scanning helical antenna (2000)

The bifilar scanning helical antenna is analyzed by considering the structure to carry a single traveling wave. It is shown that the relative phase velocity (v/c) must equal unity to yield the scanning features shown by numerical experiment. This is at complete odds with monofilament helices (Kraus), which display a slow wave structure.
Multiple collaborative kernel tracking (2005)

This paper presents a novel multiple collaborative kernel approach to visual tracking. This approach treats kernel-based tracking in a more general setting, i.e., a relaxation and constraints formulation, in which a complex motion is represented by a set of inter-correlated simpler motions. With this formulation, we present a rigorous analysis on a critical issue of kernel observability and obtain a criterion, based on which we propose a new method using collaborative kernels that has the theoretical guarantee of enhanced observability. This new method has been shown to be computationally efficient in both theory and practice, which can be readily applied to complex motions such as articulated motions.
Evaluation of RxNorm in Ambulatory Electronic Prescribing. (2011)

Drug prescriptions need to accurately identify the medications that prescribers intend for pharmacists to dispense. However, the set of computer-interpretable identifiers currently used in electronic prescribing (e-prescribing) does not support the specific needs of the prescribers and pharmacists who conduct e-prescribing transactions. RxNorm, a drug nomenclature from the National Library of Medicine, assigns a rigorously derived, centrally maintained, and publicly available unique identifier to each clinically distinct drug. It therefore has the potential to greatly improve drug identification in e-prescribing transactions. Through laboratory research and pilot testing, the authors evaluated RxNorm's potential to improve how medications are represented in e-prescribing transactions. They found that RxNorm is highly complete for prescription drugs used in ambulatory practice that are within its scope and that it offers substantial efficiency and parsimony gains for communicating health plan formulary information to prescribers. The errors that arose during use were of low clinical significance. In live pilot testing, RxNorm identifiers were successfully added to prescription transactions sent between participating prescribers and pharmacies, and the pharmacies were able to use this information to check for dispensing errors or to disambiguate prescriptions. The authors found that RxNorm appears to provide drug identifiers that more accurately reflect the prescriber's intent than the drug identifier set currently used.
Communications- Cycloaddition of Ketenes to Enamines (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCommunications- Cycloaddition of Ketenes to EnaminesR Hasek and J MartinCite this: J. Org. Chem. 1961, 26, 11, 4775–4776Publication Date (Print):November 1, 1961Publication History Published online7 March 2003Published inissue 1 November 1961https://pubs.acs.org/doi/10.1021/jo01069a602https://doi.org/10.1021/jo01069a602research-articleACS PublicationsRequest reuse permissionsArticle Views109Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vapor pressure formulation for ice (1977)

A new fonn ulation is presenl ed for Ih e vapor press ure of ice from Ihe triple point to -100C based on thermodynamic calculations. Use is made of Ih e d efinilive ex pe rim e nlal value of the vapor pressure of waler a t its triple poinl recentl y oblain ed by Cuildner , Johnson, and Jones. A tab le is given of Ihe vapor press ure as a function of le mpe rature at O.I-d egree inl e rv a ls ove r Ihe range 0 10 -100 C, logel he r wilh Ihe values of Ih e lemperature derivative at I-degree inl e rvals . T he formu laLion is compa red with published ex perime nlal meas urement s and vapor pressure equaLi ons. It is eslima led Ih at Ihi s formu lalion predi cls Ihe vapor pressure of ice wit h an ove rall unce rtainl y Ihal vari es from 0.016 pe rce nl al the Iripl e poinl 10 0.50 percenl a l -100 C. K ey wo rd s: C lausius-C lapey ron equation; sa turation vapor press ure over ice; th e rm a l properti es of ice; vapor pressure; vapor pressure at th e triple point; vapor pressure of ice; waler vapor. Pa Pa c m 3 / g c m 3 /g c m 3 /c m 3 Pa cm 3 /cm 3 Pa J/gK J/gK
An interactive high-level debugger for control-flow optimized programs (Summary) (1983)

The transformations performed by an optimizing compiler have traditionally impeded interactive debugging in source language terms. A prototype system called Navigator has been developed for debugging optimized programs written in Cedar, an Algol-like language. Navigator can be used to monitor program execution flow in the presence of two optimizations: inline procedure expansion and cross-jumping (merging identical tails of code paths that join). This paper describes the problems that these two optimizations create for debugging and Navigator's solutions to these problems. The selected approach collects extra information during the optimization phases of compilation. At runtime, Navigator uses the additional information to hide the effects of the optimizations from the programmer.
Average current-mode control and charge control for PWM converters (1994)

Two control schemes for PWM converters, average current-mode (ACM) control and charge control, are studied in this dissertation. The small-signal models are derived for continuous-conduction mode PWM converters employing these two controls. Sampled-data modeling is applied to the current loop modeling, and the obtained models are accurate up to half the switching frequency. The relationships between current loop instability and converter operating conditions for both controls are found for the first time. The derived models are verified by both time-domain simulations and experiments. The models can be used for both voltage loop and current loop analysis and designs. Comprehensive design guidelines for PWM converters with both controls are also provided. The small-signal characteristics of these two controls are compared with those of peak current-mode control. The applications of ACM control and charge control to power factor correction (PFC) circuits are studied. Charge control is applied to continuous-conduction mode flyback converter to achieve a single-stage PFC. The current loop instability in PFC circuit and its effect on the input EMI filter design are investigated. The trade-off between the current loop stability nlargin and line current distortion is also discussed.
New 4‐Amino‐7,8‐dimethoxy‐5<i>h</i>‐pyrimido[5,4‐<i>b</i>]indole Derivatives: Synthesis and Studies as Inhibitors of Phosphodiesterases (1993)

A series of 4-amino-7,8-dimethoxy-5H-pyrimido[5,4-b]indole derivatives has been synthesized. These compounds resemble carbazeram and other pyridazino compounds with activity in the cardiovascular system. Some of these new compounds possess inotropic activity (Table 2), with a complementary effect on the inhibition of different CGI-PDE (Table 3). The most active compounds 5, 6d, and 7 also possess activity as vasodilators (Table 4). Some of these new compounds inhibit blood platelet aggregation induced by ADP and AA and are active as inhibitors of human platelet PDEs (Tables 5 and 6).
Phantom based flow analysis by means of dynamic angiography, CFD and laser-doppler-velocimetry (2007)

In this paper we investigate the dynamics of contrast agent concentration as blood flow estimation method utilizing contributions from three different fields: morphologic and dynamic angiographic X-ray scans, computational fluid dynamics (CFD) simulations and Laser-Doppler-Velocimetry (LDV) measurements. Based on dynamic angiographic X-ray measurements we exploit dedicated CFD simulations, carried out specifically for each target object, for the adaptation of the plain video densitometric results. Finally, a comparison with LDV is presented.
Morphology of Pig Retinal Pigment Epithelium Maintained in Organ Culture (1988)

Exoplants of porcine retinal pigment epithelium (RPE) attached to Bruch's membrane, choroid, and sclera were maintained in organ culture for up to four weeks. Four-millimeter round buttons of eye wall that contained RPE, choroid, and sclera were trephined from freshly enucleated pig eyes and incubated at 37 degrees C in Eagle's minimum essential medium with 10% fetal calf serum. The RPE cells remained as a monolayer for at least four weeks in organ culture, and individual RPE cells became taller and dome shaped. The RPE cells retained several prominent ultrastructural features, including apical microvilli, intracellular melanosomes and mitochondria, and intercellular tight junctions. Since the cellular substratum can exert important influences on cell behavior, the ability to maintain RPE cells attached to Bruch's membrane provides a new in vitro tool for studying the metabolic activity of this tissue and its response to external stimuli, including laser photocoagulation.
Thrombin receptor (PAR-1) antagonists as novel antithrombotic agents (2006)

In addition to its central role in haemostasis and wound healing, thrombin activates platelets and smooth muscle cells by proteolytic activation of cell surface protease-activated receptor-1 (PAR-1), which is also known as the thrombin receptor. Thrombin is the most potent activator of human platelets and, as such, a thrombin receptor antagonist is likely to exert potent antithrombotic effect in platelet-rich arterial thrombosis. As thrombin receptor antagonism does not inhibit the ability of thrombin to generate fibrin, such an agent is likely to have less bleeding liability than conventional anticoagulants. The proof-of-concept of the antithrombotic effect of PAR-1 antagonists has been established in several non-human primate models. The current success of PAR-1 research is underscored by the advancement of two candidates into clinical trails for acute coronary syndrome by Schering-Plough and Eisai Company.
A 4.2bsd Interprocess Communication Primer (1983)

This report describes the internal structure of the networking facilities developed for the version of the UNIX operating system for the VAX. These facilities are based on several central abstractions which structure the external (user) view of network communication as well as the internal (system) implementation. The report documents the internal structure of the networking system. The 4.2BSD System Manual provides a description of the user interface to the networking facilities.
Sensory factors limiting horizontal and vertical visual span for letter recognition (2014)

Reading speed for English text is slower for text oriented vertically than horizontally. Three possible sensory determinants of the size of the visual span are: resolution (decreasing acuity at letter positions farther from the midline), mislocations (uncertainty about the relative position of letters in strings), and crowding (interference from flanking letters in recognizing the target letter). In the present study, we asked which of these factors is most important in determining the size of the visual span, and likely in turn in determining the horizontal/vertical difference in reading when letter size is above the critical print size for reading. We used a decomposition analysis to represent constraints due to resolution, mislocations, and crowding as losses in information transmitted (in bits) about letter recognition. Across vertical and horizontal conditions, crowding accounted for 75% of the loss in information, mislocations accounted for 19% of the loss, and declining acuity away from fixation accounted for only 6%. We conclude that crowding is the major factor limiting the size of the visual span, and that the horizontal/vertical difference in the size of the visual span is associated with stronger crowding along the vertical midline.
Computational Simulation on Performance Enhancement of Cold Gas Dynamic Spray Processes With Electrostatic Assist (2008)

A real-time computational simulation on the entire cold spray process is carried out by the integrated model of compressible flow field, splat formation model, and coating formation model, in order to provide the fundamental data for the advanced high performance cold gas dynamic spray process with electrostatic acceleration. In this computation, viscous drag force, flow acceleration added mass, gravity, Basset history force, Saffman lift force, Brownian motion, thermophoresis, and electrostatic force are all considered in the particle equation of motion for the more realistic prediction of in-flight nano∕microparticle characteristics with electrostatic force and also for the detailed analysis of particle-shock-wave-substrate interaction. Computational results show that electrostatic acceleration can broaden the smallest size of applicable particle diameter for successful adhesion; as a result, wider coating can be realized. The utilization of electrostatic acceleration enhances the performance of cold dynamic spray process even under the presence of unavoidable shock wave.
Mitosis-Specific Phosphorylation of Nucleolin by p34 <sup>cdc2</sup> Protein Kinase (1990)

Nucleolin is a ubiquitous multifunctional protein involved in preribosome assembly and associated with both nucleolar chromatin in interphase and nucleolar organizer regions on metaphasic chromosomes in mitosis. Extensive nucleolin phosphorylation by a casein kinase (CKII) occurs on serine in growing cells. Here we report that while CKII phosphorylation is achieved in interphase, threonine phosphorylation occurs during mitosis. We provide evidence that this type of in vivo phosphorylation involves a mammalian homolog of the cell cycle control Cdc2 kinase. In vitro M-phase H1 kinase from starfish oocytes phosphorylated threonines in a TPXK motif present nine times in the amino-terminal part of the protein. The same sites which matched the p34cdc2 consensus phosphorylation sequence were used in vivo during mitosis. We propose that successive Cdc2 and CKII phosphorylation could modulate nucleolin function in controlling cell cycle-dependent nucleolar function and organization. Our results, along with previous studies, suggest that while serine phosphorylation is related to nucleolin function in the control of rDNA transcription, threonine phosphorylation is linked to mitotic reorganization of nucleolar chromatin.
Genomic Analysis of a Spontaneous Model of Breast Cancer Metastasis to Bone Reveals a Role for the Extracellular Matrix (2005)

A clinically relevant model of spontaneous breast cancer metastasis to multiple sites, including bone, was characterized and used to identify genes involved in metastatic progression. The metastatic potential of several genetically related tumor lines was assayed using a novel real-time quantitative RT-PCR assay of tumor burden. Based on this assay, the tumor lines were categorized as nonmetastatic (67NR), weakly metastatic to lymph node (168FARN) or lung (66cl4), or highly metastatic to lymph node, lung, and bone (4T1.2 and 4T1.13). In vitro assays that mimic stages of metastasis showed that highly metastatic tumors lines were more adhesive, invasive, and migratory than the less metastatic lines. To identify metastasis-related genes in this model, each metastatic tumor was array profiled against the nonmetastatic 67NR using 15,000 mouse cDNA arrays. A significant proportion of genes relating to the extracellular matrix had elevated expression in highly metastatic tumors. The role of one of these genes, POEM, was further investigated in the model. In situ hybridization showed that POEM expression was specific to the tumor epithelium of highly metastatic tumors. Decreased POEM expression in 4T1.2 tumors significantly inhibited spontaneous metastasis to the lung, bone, and kidney. Taken together, our data support a role for the extracellular matrix in metastatic progression and describe, for the first time, a role for POEM in this process.
<i>N</i>-(3-oxohexanoyl)-<scp>l</scp>-homoserine lactone regulates carbapenem antibiotic production in <i>Erwinia carotovora</i> (1992)

Erwinia carotovora A.T.C.C. 39048 produces the antibiotic 1-carbapen-2-em-3-carboxylic acid. A number of mutants with a carbapenem-non-producing phenotype were selected as part of an investigation into the molecular and genetic basis of carbapenem biosynthesis. Cross-feeding studies revealed that the mutants fell into two discrete groups. Group 1 mutants were found to secrete a diffusible low-molecular-mass compound which restored carbapenem production in group 2 mutants. This compound was isolated from the spent culture supernatant of a group 1 mutant using solvent extraction, hydrophobic-interaction chromatography and silica-gel chromatography, and finally purified by reverse-phase semipreparative h.p.l.c. M.s. and n.m.r. spectroscopy revealed that the compound was N-(3-oxohexanoyl)homoserine lactone. Both D- and L-isomers were synthesized, and subsequent analysis by c.d. established that the natural product has the L-configuration. Although carbapenem production was restored by both isomers, dose-response curves indicated that the L-isomer has greater activity, with an induction threshold of about 0.5 micrograms/ml. N-(3-Oxohexanoyl)-L-homoserine lactone is, therefore, an autoregulator of carbapenem biosynthesis rather than a biosynthetic intermediate. This compound is already known for its role in autoinduction of bioluminescence in the marine bacterium Vibrio fischeri. It is also structurally-related to the A- and I-factors which are known to regulate production of antibiotics in some Streptomyces species. Its association in this work with the regulation of carbapenem biosynthesis implies a broader role for autoregulator-controlled gene expression in prokaryotes.
Heterostructure acoustic charge transport devices on molecular-beam epitaxy grown GaAs/(Al,Ga)As epitaxial layers (1990)

Molecular-beam epitaxy (MBE) has been used to grow very high quality layers for the confinement and transport of electrons in heterostructure acoustic charge transport (HACT) devices. In this paper the HACT device concept is reviewed, details of the layer structure and growth techniques are presented, and the performance of transversal filters produced with this material are discussed. It is demonstrated that the MBE growth techniques and epilayer design are adequate to produce charge transport efficiencies in excess of 0.9999 on HACT devices 1 cm (3.3 μs) long with 480 sensing taps. Considerable effort has been made to produce epilayers meeting the extremely demanding requirements of this large area device, and some details of this effort are discussed.
Simple, efficient<i>in vitro</i>synthesis of capped RNA useful for direct expression of cloned eukaryoti genes (1982)

A simple and efficient method for direct in vitro synthesis of capped transcripts of cloned eukaryotic genes is described. As an example capped transcripts were made from a plasmid containing the human fibroblast interferon gene cloned under the control of a prokaryotic promoter. These transcripts were translated in vivo in Xenopus laevis oocytes and in vitro in reticulocyte and in wheat germ cell-free protein synthesizing systems.
Possible mechanism for modulating cardiovascular system during running in humans (2005)

Cardiovascular response to running exercise was studied with a simple pulsatile cardiovascular model. Published experimental data during graded exercise were used to tune the model parameters. Study results show that cardiac output is modulated by rhythmic muscle contractions during running. It oscillates when step rate and heart rate are not synchronised but stabilises when they are synchronised. A maximum cardiac output can be achieved by synchronising step rate with heart rate at an optimal phase delay.