gebhart/patrepeval huggingface dataset:
The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4 <sup>+</sup> T Cell Decline and High Viral Load during Acute Infection (2011)

An understanding of how broadly neutralizing activity develops in HIV-1-infected individuals is needed to guide vaccine design and immunization strategies. Here we used a large panel of 44 HIV-1 envelope variants (subtypes A, B, and C) to evaluate the presence of broadly neutralizing antibodies in serum samples obtained 3 years after seroconversion from 40 women enrolled in the CAPRISA 002 acute infection cohort. Seven of 40 participants had serum antibodies that neutralized more than 40% of viruses tested and were considered to have neutralization breadth. Among the samples with breadth, CAP257 serum neutralized 82% (36/44 variants) of the panel, while CAP256 serum neutralized 77% (33/43 variants) of the panel. Analysis of longitudinal samples showed that breadth developed gradually starting from year 2, with the number of viruses neutralized as well as the antibody titer increasing over time. Interestingly, neutralization breadth peaked at 4 years postinfection, with no increase thereafter. The extent of cross-neutralizing activity correlated with CD4(+) T cell decline, viral load, and CD4(+) T cell count at 6 months postinfection but not at later time points, suggesting that early events set the stage for the development of breadth. However, in a multivariate analysis, CD4 decline was the major driver of this association, as viral load was not an independent predictor of breadth. Mapping of the epitopes targeted by cross-neutralizing antibodies revealed that in one individual these antibodies recognized the membrane-proximal external region (MPER), while in two other individuals, cross-neutralizing activity was adsorbed by monomeric gp120 and targeted epitopes that involved the N-linked glycan at position 332 in the C3 region. Serum antibodies from the other four participants targeted quaternary epitopes, at least 2 of which were PG9/16-like and depended on the N160 and/or L165 residue in the V2 region. These data indicate that fewer than 20% of HIV-1 subtype C-infected individuals develop antibodies with cross-neutralizing activity after 3 years of infection and that these antibodies target different regions of the HIV-1 envelope, including as yet uncharacterized epitopes.
Preparation of benzocyclobutenols from o-halostyrene oxides (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of benzocyclobutenols from o-halostyrene oxidesKasturi L. Dhawan, Barbara D. Gowland, and Tony DurstCite this: J. Org. Chem. 1980, 45, 5, 922–924Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/jo01293a033https://doi.org/10.1021/jo01293a033research-articleACS PublicationsRequest reuse permissionsArticle Views919Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
VASOPRESSIN SECRETION AND MEMORY IMPAIRMENT IN ALCOHOLIC KORSAKOFF'S SYNDROME (1995)

The response of arginine vasopressin (AVP) to an intravenous hypertonic saline infusion was investigated in 19 patients with alcoholic Korsakoff's syndrome, 17 non-amnesic alcoholics and 21 non-alcoholic controls. Compared with non-alcoholic controls the Korsakoff patients had elevated basal AVP levels and showed erratic fluctuation of AVP secretion, not related to changes in serum sodium levels. The non-amnesic alcoholics had a similar, but less severe derangement. Neuropsychological tests revealed significant correlations between basal AVP levels and memory performance in the non-amnesic alcoholics, raising the possibility of a common lesion--most likely in the diencephalon--for memory impairment and AVP dysregulation in chronic alcoholics.
[Sublingual salivary gland granuloma as a husbandry-induced disease in a Timor gray parrot]. (1990)

Psittacines kept as pets show a predisposition to vitamin A deficiency conditions. The lack of a varied diet, over-long storage times for seed and no knowledge regarding species specific feeding behaviour all lead to squamous cell epithelium metaplasia in the region of beak, oesophagus and trachea. The submandibular tumour of the sublingual salivary glands in parrots also belongs to this group of deficiency conditions. A granuloma of the right sublingual salivary gland in a Timor African Grey Parrot (Psittacus erythacus timneh) is described. It was classed as husbandry-dependent on the basis of an appropriate case history and a thorough assessment of the environment. The clinical appearance, the surgical procedure, follow-up treatment and the occurrence of this tumour are related with the use of illustrations.
Porous Implant Systems for Prosthesis Stabilization (1972)

HOMSY, CHARLES A. SC.D.; CAIN, THOMAS E. M.D.; KESSLER, FRED B. M.D.; ANDERSON, M. SIDNEY M.D.; KING, JOE W. M.D. Author Information
Structure of Dianosides C, D, E and F, Triterpenoid Saponins of<i>Dianthus superbus</i>var.<i>longicalycinus</i>Herb<sup>1</sup> (1984)

On the basis of chemical and spectroscopic evidence, the structures of four triterpenoid saponins, dianosides C, D, E and F, from DIANTHUS SUPERBUS var. LONGICALYCINUS herb, have been elucidated as shown in formulas 1, 2, 3 and 4, respectively.
The ETB Dosemeter, A Passive Integrating Radon Dosemeter Combining Activated Charcoal and TLD (1983)

A passive integrating radon dosemeter is described. The radon dosemeter is based on radon adsorption on activated charcoal. By placing TLD crystals inside an open charcoal container, the beta radiation from radon daughters, produced by the decay of adsorbed radon, is detected continuously during the exposure time. After closing the container, radiation will still be detected by the TLD crystal. Calibration procedures are reported and the suitability of the dosemeter is discussed. The dosemeter proved to be suitable for measurements during periods from a few days to two weeks both in domestic and mine atmospheres.
Transient increase of the labile iron pool in HepG2 cells by intravenous iron preparations (2003)

Intravenous iron, used for the treatment of anemia in chronic renal failure and other diseases, represents a possible source of free iron in tissue cells, particularly in the liver. In this study we examined the effect of different sources of intravenous iron (IVI) on the labile iron pool (LIP) which represents the nonferritin-bound, redox-active iron that is implicated in oxidative stress and cell injury. Furthermore, we examined the role of the LIP for the synthesis of ferritin. We used HepG2 cells as a well known model for hepatoma cells and monitored the LIP with the metal-sensitive fluorescent probe, calcein-AM, the fluorescence of which is quenched on binding to iron. We showed that steady state LIP levels in HepG2 cells were increased transiently, up to three-fold compared to control cells, as an adaptive response to long-term IVI exposure. In relation to the amount of iron in the LIP, the ferritin levels increased and the iron content of ferritin decreased. As any fluctuation in the LIP, even when it is only transient (e.g. after exposure to intravenous iron in this study), may result either in impairment of synthesis of iron containing proteins or in cell injury by pro-oxidants. Such findings in nonreticuloendothelial cells may have important implications in the generation of the adverse effects of chronic iron exposure reported in dialysis patients.
Frequency-domain method for the computation of propeller acoustics (1988)

In the present study an analytical description of the acoustic field of a propeller in a uniform flow is derived. Instead of applying the usual Ffowcs-Williams-Hawkings version of the acoustic analogy, here we formulate sources on a surface enclosing the propeller and its adjacent nonlinear flowfield. This approach, which avoids the laborious evaluation of quadrupole source terms, is to be considered as a generalization of the Kirchhoff-Helmholtz theorem of acoustics. By describing the fundamental solution as a spectral Fourier-Bessel decomposition, the resulting sound field is readily given in the appropriate series of harmonic amplitudes. The method is validated by a comparison of numerical results with experimental data of a propeller in an acoustic wind tunnel. A good agreement both in amplitude and phase is found between theory and experiment.
Practical hints for hemostasis in laparoscopic surgery (2007)

With the developments achieved in recent years in laparoscopic surgery, the field has acquired a host of new techniques to achieve haemostasis, allowing the surgeon to tackle complex procedures. These techniques include physical modalities (as simple as compression or suturing and as sophisticated as endovascular staples), thermal modalities (such as bipolar coagulation, laser or ultrasonic dissectors), and topical sealants (e.g. Fibrin glue or gelatine matrix). It is up to the laparoscopic surgeon to be familiar with all these different modalities and their proper use and limitations. It should also be kept in mind that the best approach to haemostasis in laparoscopy is prevention by thorough case preparation and meticulous dissection technique. We herein expose an overview of the available techniques to achieve haemostatic control in laparoscopic surgery in the emergency as well as the elective setting. Representative surgeries are used for illustrative purposes to describe special manoeuvres.
Vapor-Liquid Equilibria from Total-Pressure Measurements. A New Apparatus (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor-Liquid Equilibria from Total-Pressure Measurements. A New ApparatusRichard E. Gibbs and Hendrick C. Van NessCite this: Ind. Eng. Chem. Fundamen. 1972, 11, 3, 410–413Publication Date (Print):August 1, 1972Publication History Published online1 May 2002Published inissue 1 August 1972https://pubs.acs.org/doi/10.1021/i160043a022https://doi.org/10.1021/i160043a022research-articleACS PublicationsRequest reuse permissionsArticle Views749Altmetric-Citations157LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Nucleotide sequence and phylogeny of the tet(L) tetracycline resistance determinant encoded by plasmid pSTE1 from Staphylococcus hyicus (1992)

The nucleotide sequence of the tetracycline resistance (tet) gene and its regulatory region, encoded by the plasmid pSTE1 from Staphylococcus hyicus, was determined. The tet gene was inducible by tetracycline and encoded a hydrophobic protein of 458 amino acids. Comparisons between the predicted amino acid sequences of the pSTE1-encoded Tet from S. hyicus and the previously sequenced Tet K variants from Staphylococcus aureus, Tet L variants from Bacillus cereus, Bacillus stearothermophilus, and Bacillus subtilis, Tet M variants from Streptococcus faecalis and Staphylococcus aureus as well as Tet O from Streptococcus mutans were performed. An alignment of Tet amino acid sequences revealed the presence of 30 conserved amino acids among these Tet variants. On the basis of the alignment, a phylogenetic tree was constructed. It demonstrated large evolutionary distances between the Tet M and Tet O variants on one hand and the Tet K and Tet L variants on the other hand. The pSTE1-encoded Tet proved to be closely related to the Tet L proteins originally found on small Bacillus plasmids. The observed extensive similarities in the nucleotide sequences of the tet genes and in the deduced Tet amino acid sequences allowed the assignment of the pSTE1-encoded Tet to the Tet proteins of class L.
A Framework for Dataset Benchmarking and Its Application to a New Movie Rating Dataset (2016)

Rating datasets are of paramount importance in recommender systems research. They serve as input for recommendation algorithms, as simulation data, or for evaluation purposes. In the past, public accessible rating datasets were not abundantly available, leaving researchers no choice but to work with old and static datasets like MovieLens and Netflix. More recently, however, emerging trends as social media and smartphones are found to provide rich data sources which can be turned into valuable research datasets. While dataset availability is growing, a structured way for introducing and comparing new datasets is currently still lacking. In this work, we propose a five-step framework to introduce and benchmark new datasets in the recommender systems domain. We illustrate our framework on a new movie rating dataset—called MovieTweetings—collected from Twitter. Following our framework, we detail the origin of the dataset, provide basic descriptive statistics, investigate external validity, report the results of a number of reproducible benchmarks, and conclude by discussing some interesting advantages and appropriate research use cases.
Active control of a flexible, two-mass rotor : the use of complex notation (1986)

Thesis: Sc. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 1987
Millimeter wave propagation: spectrum management implications (2005)

The millimeter wave spectrum at 30-300 GHz is of increasing interest to service providers and systems designers because of the wide bandwidths available for carrying communications at this frequency range. Such wide bandwidths are valuable in supporting applications such as high speed data transmission and video distribution. Planning for millimeter wave spectrum use must take into account the propagation characteristics of radio signals at this frequency range. While signals at lower frequency bands can propagate for many miles and penetrate more easily through buildings, millimeter wave signals can travel only a few miles or less and do not penetrate solid materials very well. However, these characteristics of millimeter wave propagation are not necessarily disadvantageous. Millimeter waves can permit more densely packed communications links, thus providing very efficient spectrum utilization, and they can increase security of communication transmissions. This article reviews characteristics of millimeter wave propagation, including free space propagation and the effects of various physical factors on propagation.
In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs (2012)

Idiosyncratic adverse drug reactions (IADRs) in humans can result in a broad range of clinically significant toxicities leading to attrition during drug development as well as postlicensing withdrawal or labeling. IADRs arise from both drug and patient related mechanisms and risk factors. Drug related risk factors, resulting from parent compound or metabolites, may involve multiple contributory mechanisms including organelle toxicity, effects related to compound disposition, and/or immune activation. In the current study, we evaluate an in vitro approach, which explored both cellular effects and covalent binding (CVB) to assess IADR risks for drug candidates using 36 drugs which caused different patterns and severities of IADRs in humans. The cellular effects were tested in an in vitro Panel of five assays which quantified (1) toxicity to THLE cells (SV40 T-antigen-immortalized human liver epithelial cells), which do not express P450s, (2) toxicity to a THLE cell line which selectively expresses P450 3A4, (3) cytotoxicity in HepG2 cells in glucose and galactose media, which is indicative of mitochondrial injury, (4) inhibition of the human bile salt export pump, BSEP, and (5) inhibition of the rat multidrug resistance associated protein 2, Mrp2. In addition, the CVB Burden was estimated by determining the CVB of radiolabeled compound to human hepatocytes and factoring in both the maximum prescribed daily dose and the fraction of metabolism leading to CVB. Combining the aggregated results from the in vitro Panel assays with the CVB Burden data discriminated, with high specificity (78%) and sensitivity (100%), between 27 drugs, which had severe or marked IADR concern, and 9 drugs, which had low IADR concern, we propose that this integrated approach has the potential to enable selection of drug candidates with reduced propensity to cause IADRs in humans.
Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta. (1991)

Regulation of the human type 1 plasminogen activator inhibitor (PAI-1) promoter by transforming growth factor-beta (TGF beta) was studied. An 800-base pair fragment from the PAI-1 promoter and 5'-flanking region was fused to the firefly luciferase reporter gene and transfected into Hep3B human hepatoma cells. Treatment of the cells with TGF beta induced luciferase activity by more than 50-fold. Transfection studies using constructs with 5' or 3' deletions through this region revealed that two sequences were important in the TGF beta response. The first sequence was located in the proximal promoter (-49 to -87) and mediated an 11-fold induction with TGF beta, while the second more distal region (-636 to -740) contained two sequences which together mediated a 50-fold or greater response. Sequence comparison indicated that both of the responsive regions contained sequences with high homology to the AP-1 consensus binding site. Moreover, gel retardation analysis experiments demonstrated that both sequences bound a common nuclear protein, and that an oligonucleotide containing a consensus AP-1 sequence was able to compete for the binding of this common protein. Thus, the response of the PAI-1 gene to TGF beta is mediated by at least two separate regions, and both of these regions contain DNA sequences homologous to the AP-1 binding site.
Design considerations for a financial management system for rural, semi-literate users (2003)

In this paper, we describe the design process, results, and general observations obtained in designing a user interface for managing community-based micro-finance institutions in rural India. The primary users studied were semi-literate village women. We discuss our contextual study observations and conclude by presenting a grounded design approach that best leverages the existing learning patterns of the users.
DSC and TBA studies of the curing behavior of two dicy‐containing epoxy resins (1979)

Abstract The curing behavior of two commercial dicy‐containing resins (I & II), both with recommended cures of 127°C/2 h, has been studied by differential scanning calorimetry (DSC), torsional braid analysis (TBA) and Fourier Transform infrared spectroscopy. Compositional analysis reveals that the two resins differ primarily in the amine/epoxy ratio and the nature of the main epoxy components. Factors contributing to the complex curing behavior observed with II are identified. Isothermal kinetic runs by DSC and TBA lead to estimates for the conversion at the gel point, and to results which suggest that the reactions of epoxy with amine and hydroxyl occur with similar activation energies and similar heats of reaction.
Oral Communication Skills and the Black Urban Child in the Seventies (1972)

No AccessLanguage, Speech, and Hearing Services in SchoolsResearch Article1 Oct 1972Oral Communication Skills and the Black Urban Child in the Seventies Bertha R. Smith Bertha R. Smith Google Scholar More articles by this author https://doi.org/10.1044/0161-1461.0304.68 SectionsAboutPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In Additional Resources FiguresReferencesRelatedDetails Volume 3Issue 4October 1972Pages: 68-72 Get Permissions Add to your Mendeley library History Published in issue: Oct 1, 1972 Metrics Topicsasha-topicsasha-article-typesCopyright & PermissionsCopyright © 1972 American Speech-Language-Hearing AssociationLoading ...
Equivalent Conditions of K-uniformly Convex Banach Space (2007)

In this paper,a equivalent condition of K-uniformly convex Banach space is given by using functional.Then a new definition of K-uniformly convex Banach space is introduced,and a new equivalent condition of K-uniformly convex Banach space is obtained.Moreover,the corresponding results in the local K-uniformly convex Banach space is established.
Reconstruction of magnetic resonance images by iterative methods (1992)

Abstract In MRI based on the time‐varying gradient magnetic field, the image must be reconstructed from the sampled values which are distributed in k ‐space with nonuniform intervals. If there exists any static field inhomogeneity, gradient field nonlinearity, or patient motion, the image must be reconstructed considering these effects, thereby preventing the deterioration of the reconstructed image. This paper proposes a new MRI image reconstruction method to cope with the forementioned problems in a unified way. The proposed method of reconstruction is based on the principle whereby the imaging equation representing the relation between the spin density distribution and FID signal is solved directly by an iterative least‐squares method. The proposed reconstruction method strictly considers that mathematically the measured data are the finite number of sampled values of the FID signal. The minimum norm solution is obtained as the reconstructed image. Also, a method is proposed which improves the convergence of the iterative least‐squares method by utilizing the information concerning the density of the sampling point distribution in k ‐space. An image reconstruction experiment is shown assuming the spiral k ‐trajectory.
Free-standing Ag/C coaxial hybrid electrodes as anodes for Li-ion batteries (2013)

Free-standing coaxially structured Ag/carbon hybrid electrodes were prepared as potential anodes for micro-Li-ion batteries, which show excellent electrochemical performance, being essentially due to the beneficial effect of the unique structure, i.e. the Ag-core enhances the flexibility and electrochemical kinetics, while the carbon shell buffers volumetric change during cycling.