gebhart/patrepeval huggingface dataset:
Local synchronous capacity allocation schemes for guaranteeing message deadlines with the timed token protocol (2002)

The problem of guaranteeing synchronous message deadlines in communication networks using the timed token medium access control protocol is studied. To ensure the transmission of synchronous messages before their deadlines, synchronous capacities must be properly allocated to individual nodes. A class of local synchronous capacity allocation schemes, which allocate the synchronous capacity to a node without using information about messages on the other nodes, is developed, analyzed, and evaluated in terms of the ability of the schemes to guarantee message deadlines. It is shown that one of the local allocation schemes proposed can achieve the same performance as that of the best global allocation scheme known to date.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A new immunoenzymometric assay for bioactive N-terminal human parathyroid hormone fragments and its application in pharmacokinetic studies in dogs. (1998)

Advances in the treatment of clinical disorders of mineral in homeostatis and metabolic bone disease with intact parathyroid hormone 1-84 or one of the biologically active N-terminal fragments require a precise and sensitive measurement in serum. Therefore, a two-site immunoenzymometric assay for the quantitative determination of bioactive hPTH-1-37 (human parathyroid hormone) at picomolar concentrations was developed. Monoclonal antibodies (mAB) against hPTH-1-37 were raised by hybridoma cells in serum-free cell culture. Furthermore, sequence-specific polyclonal antibodies were obtained by immunisation of rabbits using multiple antigenic peptides (MAP) representing the conspicuous regions of the primary structure of hPTH-1-37. The polyclonal and monoclonal antibodies were characterised by epitope mapping. The combination of a monoclonal antibody (13C63/5) recognising hPTH fragment 16-24 with a polyclonal antibody (k2) showing a predominant binding sequence at hPTH-1-5 led to a sandwich assay specific for N-terminally intact and therefore biologically active hPTH. The validated assay ranging from 4 to 1000 pmol/l was applied to pharmacokinetic studies of hPTH-1-37. After s.c. administration of 30 mu g/kg in 5 beagles, the maximum serum concentrations of hPTH-1-37 ranging at 2139 +/- 857 pmol/l were observed 45 min after the injection. Clearance of the peptide calculated from the exponential disappearance curve was 32.0 +/- 9.1 ml/min/kg with a mean t1/2 of 37 +/- 10 min.
Strategies for data reengineering (2003)

This paper describes and analyzes a series of strategies to migrate data-intensive applications from a legacy data management system to a modern DMS. Considering two ways to migrate the data and three ways to propagate the corresponding perturbation to the program code, the paper identifies six reference strategies that provide different levels of quality and induce different costs. Three of them are discussed in detail and illustrated by the conversion of COBOL files into a SQL database.
One‐pot Synthesis of Oxindoles through C−H Alkylation and Intramolecular Cyclization of Azobenzenes with Internal Olefins (2017)

Abstract The rhodium(III)‐catalyzed site‐selective C−H alkylation of azobenzenes and internal olefins, such as maleimides, maleates and fumarates, followed by reductive intramolecular cyclization is described. A cationic rhodium catalyst in the presence of acetic acid additive in dichloroethane solvent was found to be the optimal catalytic system for the construction of ortho ‐alkylated azobenzenes, which smoothly underwent the intramolecular cyclization leading to the formation of C3‐functionalized oxindoles in the presence of zinc powder and acetic acid. The formed oxindole scaffold could be an important asset towards the development of novel bioactive compounds. magnified image
Preparation and Properties of Some Hexadecyl Hydrogen Esters of Dibasic Acids (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Properties of Some Hexadecyl Hydrogen Esters of Dibasic AcidsW. Frederick Huber and E. S. LuttonCite this: J. Am. Chem. Soc. 1957, 79, 14, 3919–3920Publication Date (Print):July 1, 1957Publication History Published online1 May 2002Published inissue 1 July 1957https://doi.org/10.1021/ja01571a079RIGHTS & PERMISSIONSArticle Views97Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (268 KB) Get e-Alerts Get e-Alerts
Evidence Supporting a Key Role of Lp-PLA2-Generated Lysophosphatidylcholine in Human Atherosclerotic Plaque Inflammation (2012)

The associations among Lp-PLA2, lysoPCs, LPA, and proinflammatory cytokines in human plaques suggest that lysoPCs play a key role in plaque inflammation and vulnerability. Our findings support Lp-PLA2 inhibition as a possible strategy for the prevention of cardiovascular disease.
Inhibitors of Cytokine Signal Transduction (2004)

Cytokines are secreted proteins that regulate diverse biological functions by binding to receptors at the cell surface to activate complex signal transduction pathways including the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. Stringent mechanisms of signal attenuation are essential for ensuring an appropriate, controlled cellular response. Three families of proteins, the SH2-containing phosphatases (SHP), the protein inhibitors of activated STATs (PIAS), and the suppressors of cytokine signaling (SOCS), inhibit specific and distinct aspects of cytokine signal transduction. The analysis of mice lacking genes for members of the SHP and SOCS families has shed much light on the roles of these proteins in vivo. In recent in vitro studies, the protein modifiers ubiquitin and SUMO (small ubiquitin-like modifier) have emerged as key players in the strategies employed by SOCS and PIAS to repress signaling.
Azure SQL Database (2016)

Microsoft Azure SQL Database is a relational database service in Microsoft Azure based on the Microsoft SQL Server engine, with almost all the mission-critical capabilities of SQL Server. Windows Azure SQL Database is designed to deliver highly available and scalable database as a service with predictable performance, business continuity, and data protection capabilities. SQL Database is a platform as a server offering, and it requires very little administrative overhead and can significantly reduce the time-to-market for applications requiring database backend support. Since the service is based on the SQL Server engine, it works with most of the SQL Server tools and APIs available, making it easier to migrate existing applications to Azure.
Microstructure and Sinterability of Nano-Crystal Tungsten Powders (2005)

Tungsten (W) is a useful material because of its high performances such as high melting temperature (Tm: 3653 K) and high strength (Young's modulus: 403 GPa). However, its high melting temperature requires high sintering temperature for producing a bulk W material, and it has a high Ductile-Brittle Transition Temperature which leads to brittleness at room temperature. To improve such negative properties, a nano grain structure formation is very effective. In the present study, a Mechanical Milling (MM) process is applied to W powder and W-Re powder mixtures. The MM process enables to produce a nano grain microstructure very easily and has been applied to many powder materials. Pure W powder or W-3 mass% or 10 mass% Re powder mixture is charged into steel vials with steel balls and rotated using a planetary ball milling at 200 rpm for 360 ks under Ar atmosphere. The MM powders are then sintered by spark plasma sintering (SPS) equipment at the temperature range of 1273 K to 1873 K under the compaction pressure of 50 MPa. The compacts and powders are examined by means of XRD, SEM and TEM/EDS. As a result, in the MM powder a nano grain structure, whose grain size is approximately 10 nm, is obtained after MM for 360 ks. The MM process enables sintering of the powders at 1273 K, while approximately 1673 K is necessary for non-MM powder to be sintered. Re addition prevents grain growth during sintering and thus increases hardness of the compacts.
Imidazol-1-yl and pyridin-3-yl derivatives of 4-phenyl-1,4-dihydropyridines combining Ca2+ antagonism and thromboxane A2 synthase inhibition (1993)

A series of derivatives of 4-phenyl-1,4-dihydropyridine bearing imidazol-1-yl or pyridin-3-yl moieties on the phenyl ring were synthesized with the aim of combining Ca2+ antagonism and thromboxane A2 (TxA2) synthase inhibition in the same molecule. Some of these compounds showed significant combined Ca2+ antagonism and TxA2 synthase inhibition in vitro, while others showed only one single activity. Structural requirements for significant single or combined activities are discussed. Theoretical conformational analysis, by molecular mechanics and semiempirical AM1 calculations, was performed for 1,4-dihydro-2,6-dimethyl-4-[3-(1H-imidazol-1-yl)phenyl]- 3,5-pyridinedicarboxylic acid, diethyl ester (FCE 24265) and two close congeners. FCE 24265, which inhibited TxB2 production in rat whole blood with IC50 = 1.7 x 10(-7) M and antagonized K+ induced contraction in guinea pig aorta with IC50 = 6.0 x 10(-8) M, was selected for further pharmacological evaluation. Our results show that this compound is less potent than nifedipine both in vitro and in vivo yet presents a favorable profile in vivo, lowering blood pressure without inducing reflex tachycardia. Moreover, its additional potent and selective TxA2 synthase inhibitory activity makes this compound an interesting pharmacologic tool in pathologies where both enhanced TxA2 synthesis and cellular Ca2+ overload are involved.
Continuous Analysis of Collaborative Design (2017)

In collaborative design, architects' individual design decisions may conflict and, when joined, may violate system consistency rules or non-functional requirements. These design conflicts can hinder collaboration and result in wasted effort. Proactive detection of code-level conflicts has been shown to improve collaborative productivity, however, the computational resource requirements for proactively computing design conflicts have hindered its applicability in practice. Our survey and interviews of 50 architects from six large software companies find that 60% of their projects involve collaborative design, that architects consider integration costly, and that design conflicts are frequent and lead to lost work. To aid collaborative design, we re-engineer FLAME, our prior design conflict detection technique, to use cloud resources and a novel prioritization algorithm that, together, achieve efficient and nonintrusive conflict detection, and guarantee a bound on the time before a conflict is discovered. Two controlled experiments with 90 students trained in software architecture in a professional graduate program, demonstrate that architects using FLAME design more efficiently, produce higher-quality designs, repair conflicts faster, and prefer using FLAME. An empirical performance evaluation demonstrates FLAME's scalability and verifies its time-bound guarantees.
A design representation for hardware/software co-synthesis (2002)

This paper presents a design representation for digital designs consisting of both hardware and software components. The design representation is used to capture designs during the synthesis process from a high-level behavioural specification to its structural implementation. It is based on timed Petri nets which are used for representing the control flow. These are extended with a formal notation to capture data manipulation by both software and hardware. Based on the representation, a hardware/software co-design environment is being built, which includes procedures for design evaluation, hardware/software partitioning, and movement of functionality from hardware to software and vice versa.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A new concept of a hybrid trapped field magnet lens (2018)

In this paper, a new concept of a hybrid trapped field magnet lens (HTFML) is proposed. The HTMFL exploits the 'vortex pinning effect' of an outer superconducting bulk cylinder, which is magnetized as a trapped field magnet (TFM) using field-cooled magnetization (FCM), and the 'diamagnetic shielding effect' of an inner bulk magnetic lens to generate a concentrated magnetic field higher than the trapped field from the TFM in the bore of the magnetic lens. This requires that, during the zero-field-cooled magnetization process, the outer cylinder is in the normal state (T> superconducting transition temperature, T c) and the inner lens is in the superconducting state (T < T c) when the external magnetizing field is applied, followed by cooling to an appropriate operating temperature, then removing the external field. This is explored for two potential cases: (1) exploiting the difference in T c of two different bulk materials ('case-1'), e.g. MgB2 (T c = 39 K) and GdBaCuO (T c = 92 K) or (2) using the same material for the whole HTFML, e.g., GdBaCuO, but utilizing individually controlled cryostats, the same cryostat with different cooling loops or coolants, or heaters that keep the outer bulk cylinder at a temperature above T c to achieve the same desired effect. The HTFML is verified using numerical simulations for 'case-1' using an MgB2 cylinder and GdBaCuO lens pair and for 'case-2' using a GdBaCuO cylinder and GdBaCuO lens pair. As a result, the HTFML could reliably generate a concentrated magnetic field B c = 4.73 T with the external magnetizing field B app = 3 T in the 'case-1', and a higher B c = 13.49 T with higher B app = 10 T in the 'case-2', respectively. This could, for example, be used to enhance the magnetic field in the bore of a bulk superconducting NMR/MRI system to improve its resolution.
Priming with Interferon-α <sub>1</sub> or Interferon-α <sub>2</sub> Enhances the Production of Both Subtypes Simultaneously (1995)

A short period of incubation with interferon-alpha ("priming") increases the amounts of IFN-alpha formed by human peripheral blood leukocytes when subsequently induced with a virus. We investigated specifically the effect of priming on the production of two individual subtypes, IFN-alpha 1 and IFN-alpha 2. The rate of interferon synthesis and the amounts formed were equally potentiated in leukocytes primed with either IFN-alpha 1 or IFN-alpha 2. Whichever of these was used for priming had no selective effect on the relative increased production of IFN-alpha 1 or IFN-alpha 2.
Treatment of Mice with Dextran Sulfate Sodium-Induced Colitis with Human Interleukin 10 Secreted by Transformed<i>Bifidobacterium longum</i> (2011)

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) the etiology of which has not yet been fully clarified. Cytokine interleukin-10 (IL-10) plays a central role in downregulating inflammatory cascade in UC and is likely a candidate for therapeutic intervention. However, its intravenous administration is costly and inconvenient. Therefore, we established a novel IL-10 delivery system by transforming a hIL-10-containing plasmid into B. longum (BL-hIL-10) and investigated its effects on 5% dextran sulfate sodium (DSS)-induced ulcerative colitis in mice and the possible underlying mechanism. Our results show that (1) hIL-10 was expressed and secreted into the culture supernatant of BL-hIL-10 after L-arabinose induction in vitro as examined by Western blot, enzyme-linked immunosorbent assay (ELISA) and RT-PCR; (2) addition of BL-hIL-10 culture supernatant had no cytotoxic effect and morphological alteration, but significantly inhibited the enhancement of proinflammatory cytokines by lipopolysaccharide (LPS) in THP-1 cells; (3) oral administration of BL-hIL-10 alleviated colitis syndrome of the model mice, attenuated colitis-activated NF-κB pathway measured by DNA-binding assay and colitis-elevated expression of proinflammatory cytokines examined with CCK cytotoxic kits, and upregulated CD4+CD25+Foxp3+ Treg in blood and mesenteric lymph nodes measured by flow cytometry. In conclusion, BL-hIL-10 as a novel oral hIL-10 delivery system has been successfully established and oral administration of BL-hIL-10 alleviated inflammatory damage of colonic tissue in the model mice by blocking the colitis-activated NF-κB pathway and upregulating CD4+CD25+Foxp3+ Treg in blood and mesenteric lymph nodes in mice.
Oridonin alters the expression profiles of MicroRNAs in BxPC-3 human pancreatic cancer cells (2015)

Our data indicates that oridonin inhibits BxPC-3 cells probably through regulating the expression of miRNAs. Interruption of miRNA profiling may provide new therapeutic methods for the clinical treatment of pancreatic cancer.
Clonidine: irritant and allergic contact dermatitis assays (1985)

Clonidine in petrolatum, clonidine transdermal device, and its placebo device were assayed for relative irritancy potential (21-day cumulative irritancy assay) and allergic contact dermatitis potential (Draize repeat insult patch test assay). Both clonidine in petrolatum and the clonidine transdermal device appear to be of minimal irritancy potential. Only the clonidine device demonstrated, in the Draize assay (and in clinical trials), allergic contact dermatitis potential. Its relatively delayed onset of demonstration of allergic contact sensitization in clinical trials requires investigation as to mechanism.
Anion Exchange Membranes (2017)

This chapter focuses on the chemical stability of anion exchange membranes (AEMs) and synthetic approaches to mitigate the chemical degradation. It discusses the chemical degradation mechanisms of cationic groups and polymer backbones in AEMs. The chapter outlines the synthetic approaches to chemically stable AEM materials and provides examples. The chemical degradation of AEMs can occur in cationic functional groups and polymer backbones, including polymer–cationic-group linkages. AEMs can be quite stable if appropriately structured cationic groups and polymer backbones are chosen. The chapter discusses the preparation of various stable, high-performing AEMs. The chemical stability of AEMs under high-pH conditions plays a critical role in alkaline-membrane-based electrochemical devices. The stability of organic compounds under basic conditions has been investigated for decades, and substantial research progress has been made towards understanding the stability of cationic groups and polymer backbones.
MultiNet (2012)

This demo presents MultiNet, a novel method for joining devices to a domestic Wi-Fi network. MultiNet dynamically reconfigures the network to accept each device, rather than configuring each device to fit the network as is the norm. It does so by assuming that each device is pre-configured with a cryptographically generated WPA2 network SSID/passphrase pair, and then providing a lightweight interaction through which the user creates a new network for each device. This approach makes securely adding devices to a wireless network straightforward without compromising security or burdening the user, and maintaining backward compatibility with existing deployed standards and protocols.
Secondary prevention of stroke: does dipyridamole add to aspirin? (1994)

Aspirin used alone reduces secondary occurrence of vascular events in cerebrovascular patients. There is no evidence, however, of a reduction of fatal events (vascular deaths and fatal strokes). In contrast, aspirin in combination with dipyridamole reduces non-fatal as well as fatal events. These results as well as the indirect comparisons of the risk reductions suggest that the combination of aspirin with dipyridamole may be superior to aspirin alone; this hypothesis is presently tested in a large randomized trial.
Investigation of ionospheric electron content variations before earthquakes in southern California, 2003–2004 (2007)

It has been proposed that earthquakes are preceded by electromagnetic signals detectable from ground‐ and space‐based measurements. Ionospheric anomalies, such as variations in the electron density a few days before earthquakes, are one of the precursory signals proposed. Since Global Positioning System (GPS) data can be used to measure the ionospheric total electron content (TEC), the technique has received attention as a potential tool to detect ionospheric perturbations related to earthquakes. Here, we analyze 2 years (2003–2004) of data from the Southern California Integrated GPS Network (SCIGN), a dense network of 265 continuous GPS stations centered on the Los Angeles basin, for possible precursors. This time period encompasses the December 2003, M6.6, San Simeon and September 2004, M6.0, Parkfield earthquakes. We produce TEC time series at all SCIGN sites and apply three different statistical tests to detect anomalous TEC signals preceding earthquakes. We find anomalous TEC signals but no statistically significant correlation, in time or in space, between these TEC anomalies and the occurrence of earthquakes in southern California for the 2003–2004 period. This result does not disprove the possibility of precursory phenomena but show the signal‐to‐noise ratio of a hypothetical TEC precursor signature is too low to be detected by the analysis techniques employed here. Precursors may still be revealed for future large earthquakes in well instrumented areas such as California and Japan, if the tests can be developed into techniques that can better separate external influences from the actual TEC signal.
HEAT FLUX AT BURNOUT (1959)

BS> The heat flux that causes burnout of electrically heated surfaces that are water-cooled by forced convection was determined for both annular and rectangular coolant passages. The data are correlated by (Q/A/sub Burnout/ = 266,000 (1 + 0.0365V)(1 + 0.00914T/sub s/) (1 + O.O131P), where Q/A is the heat flux in pcu/(hr) (ft/sup2/), V is the water velocity in ft/sec, T/sub 2/ is the subcooling in degrees C, and P is the pressure in psia. Surface curvature, equivalent diameter, and material of heated surface are shown to have a negligible effect on the heat flux at burnout for the ranges studied. (auth)