gebhart/patrepeval huggingface dataset:
Rapid intravenous infusion of d-1 sotalol: time to onset of effects on ventricular refractoriness, and safety (1995)

Journal Article Rapid intravenous infusion of d-1 sotalol: time to onset of effects on ventricular refractoriness, and safety Get access D. S. W. Ho, D. S. W. Ho Cardiology Unit, Westmead Hospital, Westmead, Sydney, NSW, 2145, Australia Correspondence: Dr David S. W. Ho, Cardiology Unit, Westmead Hospital, Westmead, Sydney, NSW, 2145, Australia. Search for other works by this author on: Oxford Academic PubMed Google Scholar R. P. Zecchin, R. P. Zecchin Cardiology Unit, Westmead Hospital, Westmead, Sydney, NSW, 2145, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar M. J. Cooper, M. J. Cooper Cardiology Unit, Westmead Hospital, Westmead, Sydney, NSW, 2145, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar D. A. B. Richards, D. A. B. Richards Cardiology Unit, Westmead Hospital, Westmead, Sydney, NSW, 2145, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar J. B. Uther, J. B. Uther Cardiology Unit, Westmead Hospital, Westmead, Sydney, NSW, 2145, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar D. L. Ross D. L. Ross Cardiology Unit, Westmead Hospital, Westmead, Sydney, NSW, 2145, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar European Heart Journal, Volume 16, Issue 1, January 1995, Pages 81–86, https://doi.org/10.1093/eurheartj/16.1.81 Published: 01 January 1995
Effect of brimonidine on pupil diameter (2005)

We read with interest the articles by Thordsen and coauthors1 and Kesler and coauthors2 regarding the effect of brimonidine tartrate on pupil diameter. Brimonidine is a selective α2 agonist, and stimulation of α2 receptors on presynaptic sympathetic nerve terminals decreases the production, storage, and release of norepinephrine. Unsurprisingly, brimonidine in both 0.2% and 0.15% concentrations will blunt the normal sympathetically mediated pupil dilation that occurs when environmental illumination is reduced. Thordsen and coauthors and Kesler and coauthors propose that brimonidine may palliate low-light vision disturbances after refractive surgery in patients with effective optical zones smaller than their dark-adapted pupils. Thordsen and coauthors further suggest that the response to brimonidine could be incorporated into the preoperative assessment and consent process so individuals with large pupils could be informed that “they may require drops postoperatively to help minimize symptoms.” Tonic reduction of norepinephrine levels in the synaptic junction leads to up-regulation of α1 receptors on the iris dilator muscle. In a study of 10 normal subjects, Brown and coauthors3 showed that once-daily dosing with brimonidine 0.15% initially blocked the pupil dark response, but this effect was blunted within 5 to 11 days (tachyphylaxis); when the medication was discontinued, rebound mydriasis (dark-adapted pupil larger than at baseline) resulted when up-regulated α1 receptors were exposed to normal levels of norepinephrine (Figure 1). Tachyphylaxis was seen in 100% of subjects who showed an initial response. One of us (S.M.B.) performed the same trial on herself using brimonidine 0.2% and experienced tachyphylaxis within 3 days, followed by rebound mydriasis. Rebound mydriasis could be functionally devastating to refractive surgery patients who suffer from disruptive levels of glare disability.Figure 1.: Pupil diameter after dark adaptation at 1 lux for 5 minutes. The right eye was treated with brimonidine 0.15% once daily at noon, and photographs were taken 4 to 6 hours later. Tachyphylaxis began between 5 days and 11 days, and rebound mydriasis occurred when brimonidine was discontinued. This subject's data were collected as part of a previous study.3Since brimonidine cannot be used chronically for the relief of low-light visual symptoms, its usefulness in the preoperative-assessment and informed-consent process for refractive surgery is uncertain. Patients should not be given to understand that brimonidine will reliably and consistently reduce their dark-adapted pupil diameters when needed if such a need might arise on a daily or frequent basis. Sandra M. Brown MD Arshad M. Khanani MD aConcord, North Carolina, USA bLubbock, Texas, USA
Design of Porous Scaffolds for Cartilage Tissue Engineering Using a 3D fiber-deposition Technique (2004)

In this study, we present and characterize a fiber deposition technique for producing three-dimensional poly(ethylene glycol)-terephthalate—poly(butylene terephthalate) (PEGT/PBT) block co-polymer scaffolds with a 100% interconnecting pore network for engineering of articular cartilage. The technique allowed us to “design-in” desired scaffold characteristics layer by layer by accurately controlling the deposition of molten co-polymer fibers from a pressure-driven syringe onto a computer controlled x–y–z table. By varying PEGT/PBT composition, porosity and pore geometry, 3D-deposited scaffolds were produced with a range of mechanical properties. The equilibrium modulus and dynamic stiffness ranged between 0.05–2.5 and 0.16–4.33 MPa, respectively, and were similar to native articular cartilage explants (0.27 and 4.10 MPa, respectively).

3D-deposited scaffolds seeded with bovine articular chondrocytes supported a homogeneous cell distribution and subsequent cartilage-like tissue formation following in vitro culture as well as subcutaneous implantation in nude mice. This was demonstrated by the presence of articular cartilage extra cellular matrix constituents (glycosaminoglycan and type II collagen) throughout the interconnected pore volume. Similar results were achieved with respect to the attachment of expanded human articular chondrocytes, resulting in a homogenous distribution of viable cells after 5 days dynamic seeding.

The processing methods and model scaffolds developed in this study provide a useful method to further investigate the effects of scaffold composition and pore architecture on articular cartilage tissue formation.
Dynamic Resource Partitioning for Downlink Femto-to-Macro-Cell Interference Avoidance (2010)

Femto-cells consist of user-deployed Home Evolved NodeBs (HeNBs) that promise substantial gains in system spectral efficiency, coverage, and data rates due to an enhanced reuse of radio resources. However, reusing radio resources in an uncoordinated, random fashion introduces potentially destructive interference to the system, both, in the femto and macro layers. An especially critical scenario is a closed-access femto-cell, cochannel deployed with a macro-cell, which imposes strong downlink interference to nearby macro user equipments (UEs) that are not permitted to hand over to the femto-cell. In order to maintain reliable service of macro-cells, it is imperative to mitigate the destructive femto-cell to macro-cell interference. The contribution in this paper focuses on mitigating downlink femto-cell to macro-cell interference through dynamic resource partitioning, in the way that HeNBs are denied access to downlink resources that are assigned to macro UEs in their vicinity. By doing so, interference to the most vulnerable macro UEs is effectively controlled at the expense of a modest degradation in femto-cell capacity. The necessary signaling is conveyed through downlink high interference indicator (DL-HII) messages over the wired backbone. Extensive system level simulations demonstrate that by using resource partitioning, for a sacrifice of 4% of overall femto downlink capacity, macro UEs exposed to high HeNB interference experience a tenfold boost in capacity.
Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice. (1988)

Human rIL-1 alpha and human rIL-1 beta were examined for their ability to potentiate the lethal and hypothermic effects of mouse rTNF-alpha in mice. The LD50 of rTNF-alpha was 1.5 micrograms/mouse, whereas the LD50 of rTNF-alpha was reduced to 0.4 micrograms/mouse and 0.5 micrograms/mouse when rTNF-alpha was administered in combination with a nonlethal dose of rIL-1 alpha or rIL-1 beta, respectively. A similar rTNF-alpha enhancing effect of the rIL-1 was observed on the temperature response. The results show that the rIL-1 markedly potentiate the effects of rTNF-alpha on lethality and temperature in mice, and support our suggestion that TNF-alpha and IL-1 may have synergistic lethal effect in human septic shock.
Chronic fatigue syndrome (1995)

This review considers the latest information concerning chronic fatigue syndrome. Changes in the research case definition broaden the study population and suggest relevant subgroups. Studies of suspect viral etiologic agents, immunologic mediators, and health outcomes are beginning to shed some light on this baffling illness.
Total Synthesis of (±)‐γ‐Rubromycin on the Basis of Two Aromatic Pummerer‐Type Reactions (2007)

Double or nothing: In a convergent synthesis of the title compound, a potent inhibitor of human telomerase, two different aromatic Pummerer-type reactions were employed to construct the pivotal bisbenzannelated spiroketal skeleton from the two fragments shown in the scheme. This methodology offers convenient access to a wide range of substituted bisbenzannelated spiroketals from naphthol derivatives. MOM=methoxymethyl.
Phytochemical analysis, antioxidant and antibacterial effects of sea buckthorn berries. (2011)

Sea buckthorn berries are therapeutically used as folk medicine for a variety of diseases, however, the scientific evidence is hardly available to support their role. This study explored their chemical constituents and their role as antioxidant and antibacterial agents. Three common solvents such as petroleum ether (40° - 60°C), chloroform and methanol were successively used for the extraction of active principles from sea buckthorn berries. Five major fractions (F1-F5) were isolated from the active methanol extract by column and thin layer chromatography. An attempt was made to identify the chemical nature of pooled fractions by available spectral means. Antioxidant potential of methanol extract and its fractions was measured by DPPH, formation of phosphomolybdenum complex and TBA methods. The hole-plate diffussion method was used to find out the antibacterial activity. A very brief structure-activity relationship of the potent antioxidant and antimicrobial compounds is discussed. Methanolic extract and its fractions contain numerous phenolic compounds such as flavonoids, which may be responsible for antioxidant and antibacterial effects.
Fingertip Pulse Wave (PPG signal) Analysis and Heart Rate Detection (2012)

Abstract- To study heart beat pulse wave propagation in real time and to evaluate the vascular blood flow resistance an important physiological parameter for vascular diagnostics. Photoplethysmography is a non-invasive technique that measures relative blood volume changes in the blood vessels close to the skin. PPG analysis emphasizes the importance of early evaluation of the diseases We present the results of analysis of photoplethysmography (PPG) signal having motion artifacts which are as alike Gaussian noise in nature. We have proposed a methodology in detecting Heart rate and respiration rate after performing noise cancellation i.e. removing the motion artifacts of the PPG signal. Significance of different Wavelets such as db4, bior3.3, coif1, sym2, haar discussed for removing the motion artifacts. A novel beat rate extraction algorithm (BREA) is implemented monitor the heart rate and respiratory rate of peripheral pulse which has a steep rise and notch on falling slope in the subjects and a more gradual rise and fall and very small dicrotic notch.
Regulation of autophagy by amino acids and MTOR-dependent signal transduction (2014)

Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction which controls the major metabolic pathways. Among these is the pathway of autophagy which takes care of the degradation of long-lived proteins and of the elimination of damaged or functionally redundant organelles. Proper functioning of this process is essential for cell survival. Dysregulation of autophagy has been implicated in the etiology of several pathologies. The history of the studies on the interrelationship between amino acids, MTOR signaling and autophagy is the subject of this review. The mechanisms responsible for the stimulation of MTOR-mediated signaling, and the inhibition of autophagy, by amino acids have been studied intensively in the past but are still not completely clarified. Recent developments in this field are discussed.
Recurrence risk after first febrile seizure and effect of short term diazepam prophylaxis. (1985)

In a prospective randomised study, 289 children admitted consecutively to hospital with their first febrile seizure were allocated, by date of admission, to short term diazepam prophylaxis (n = 152) or to no prophylaxis (n = 137) and followed for 18 months. In untreated children, five major risk factors for recurrent febrile convulsions were identified: age 15 months or less at the time of the first febrile seizure, epilepsy in first degree relatives, febrile convulsions in first degree relatives, a first complex febrile seizure, and day nursery care. The 18 month recurrence rate was 80 to 100% if three to five risk factors were present, 50% if two factors were identified, 25% where one factor was found, and 12% if there were no predictors. During prophylaxis the recurrence rate was uniformly low (mean 12%) in all risk groups. In high (three or more factors) and intermediate (two factors) risk children prophylaxis provided effective seizure control and reduced the recurrence rate from 80%, or more, to 12% and 50% to 12%, respectively. In children with one risk factor 50% of all recurrences were prevented (25% to 12%). Prophylaxis was ineffective in very low risk children (12% to 12%).
Motion Activated Video Surveillance Using TI DSP (1999)

Traditional video surveillance takes a huge amount of storage space. Recording everything captured by a surveillance camera consumes excessively the storage space and hence limits the duration of video that can be stored. In addition, recording everything makes it time-consuming for a human to review the stored video. All these disadvantages limit the effectiveness of traditional video surveillance. In this paper, we propose to solve these problems by recording only video that contains important information, i.e., video that contains motion in the scene. This can be done with a digital video camera and a DSP algorithm that detects motion. The TI DSP ‘C54 is perfect for this application, since it is small, cheap and requires very low power. In this paper, we report a video surveillance system we developed based on TI DSP ‘C54. In this system, reliable motion detection is a non-trivial task. Especially, when the lighting condition changes, it is difficult to distinguish real motion from lighting changes. We present our algorithm that robustly distinguishes motion from lighting changes by removing the mean from the frame difference signal.
Managing elevated intracranial pressure (2004)

The treatment strategy to manage increased intracranial pressure includes decisions about anaesthetics, ventilation, head and body position, hypothermia, the use of osmotic drugs and surgical procedures. Propofol seems to be suitable for the sedation of patients with elevated intracranial pressure. Sudden increases in intracranial pressure can be treated using hyperosmotic agents, high-dose thiopental, or short episodes of mild hyperventilation. Surgical decompression of the cranium seems to improve the outcome in patients below the age of 50 years, especially children.
How pre-service teachers incorporate technology into lessons during their practice teaching experience: An intrinsic case study (2000)

How to prepare students to teach has long been a subject of debate and research. Finding the right formula to incorporate coursework, field experiences, technology and assessment so that a level of competency is achieved leading to certification has been at the center of that debate and research of teacher preparation programs. Very little has been done to determine the effectiveness of the technology aspect of their pre-service training. Instructional technology was defined for this study as anything that is accessed through or connected to a computer. Requiring students to meet technology standards judged as appropriate for teachers is becoming more common. But the effectiveness in preparing them to use technology in their teaching is what we, as educators needed to understand. Little information has been disseminated in the literature about pre-service teachers' use of technology in their practice teaching experience. Pre-service teachers involved in their practice teaching experiences at three different levels—elementary, middle and high school, were studied. Of particular interest were their experiences of incorporating technology into the lessons taught in the practice teaching settings to which they had been assigned. Participants were purposefully selected because of their pre-service training in technology, their availability and their willingness to participate in the study. Data collection was through observations, interviews and the review of related documents. Data analysis was conducted simultaneously with the data collection. Emerging themes were sorted and coded to provide a framework for the writing. Member checks, an external audit and triangulation all validated the findings. Limiting the generalizability of the findings to this group and limiting the possibility of replicating the study served as validation also. The confidentiality of the participants was protected by the use of pseudonyms. The findings will be especially helpful in the reform of teacher preparation programs and to those who are responsible for hiring teachers. The themes identified in this study that influenced the use of instructional technology by the pre-service teachers were personal enjoyment, student interest, teacher preparation programs, modeling by the cooperating teacher and access. Recommendations include teaching the use of technology in the content area of teacher preparation programs; screening cooperating teachers for instructional technology competencies; modeling by university professors; and a follow up study of these participants to determine the impact of the cooperating teacher's role in shaping their teaching practices.
Introduction to microwave circuits: radio frequency and design applications (2001)

Preface Acknowledgments Microwave Circuits Models, Modeling, and Characterization S - Parameter Measurement Methods Multiport and Differential - Mode Scattering Parameters Stability, Stabilization, and Gain Matching Networks, Attenuators, and Phase Shifters RF/Microwave Power Generation Considerations Resonators and Oscillators Microwave Filter Design Noise Considerations for Microwave Circuits Detection and Mixing Microwave Components Pulsed Microwave Circuit Analysis Nonlinear Effects in Microwave Circuits Amplifier, Oscillator, and Filter Circuit Design Examples Appendix A: An Approximate Formula for the Characteristic Impedance of a Microstrip Line Appendix B: Some Complex Variable Facts Appendix C: Matric Multiplication Appendix D: Resistor, Capacitor, and Inductor Component Modeling Appendix E: Chip Resistor Sizes - Nominal Sizes Only Appendix F: S Parameters (Scattering Parameters - Current Referenced) Appendix G: Modeling Using an Equivalent Mechanical Model Bibliography Index About the Author.
Coherent combination of four laser beams in a multi-axis Fourier cavity using a diffractive optical element (2001)

Thermal aberrations in diode-pumped solid-state laser media are well known. To avoid these effects we propose to end-pump separated zones of a laser crystal with elementary beams of moderate power. We present a multi-axis laser cavity with a single-gain medium longitudinally pumped by four fibre-coupled laser diodes. The four elementary laser beams are coherently combined inside the cavity by a diffractive optical element. 82% of the laser power is focused in a single diffraction limited beam.
An Immunohistochemical Analysis of PD-L1 Protein Expression in Surgically Resected Small Cell Lung Cancer Using Different Antibodies and Criteria. (2016)

The results of this study provided detailed evidence on the frequency of PD-L1 expression in surgically resected SCLC, which may be a useful reference for identifying patients with PD-L1-expressing SCLC.
Nonintercepting emittance monitor (1983)

A nonintercepting emittance monitor is a helpful device for measuring and improving particle beams in accelerators and storage rings as it allows continuous monitoring of the beam's distribution in phase space, and perhaps closed loop computer control of the distributions. Stripline position monitors are being investigated for use as nonintercepting emittance monitors for a beam focused by a FODO array in the first 100 meters of our linear accelerator. The technique described here uses the signal from the four stripline probes of a single position monitor to measure the quadrupole mode of the wall current in the beam pipe. This current is a function of the quadrupole moment of the beam, sigma/sup 2//sub x/ - sigma/sup 2//sub y/. In general, six independent measurements of the quadrupole moment are necessary to determine the beam emittance. This technique is dependent on the characteristically large variations of sigma/sup 2//sub x/ - sigma/sup 2//sub y/ in a FODO array. It will not work in a focusing system where the beam is round at each focusing element.
Parenteral vs. oral sumatriptan and naratriptan: plasma levels and efficacy in migraine. A comment (2007)

The clinical efficacy in migraine was compared for oral and subcutaneous sumatriptan and naratriptan. Doses of the two administration forms were chosen as resulting in comparable blood concentrations. Subcutaneous administrations of the drugs were superior for efficacy than the oral forms. This most likely due to a quicker rise in blood concentrations after subcutaneous injections.. In designing new therapies for migraine one should aim at a quick absorption of the drug, which will probably result in an increased efficacy.
A unified OpenCL-flavor programming model with scalable hybrid hardware platform on FPGAs (2014)

Hardware accelerators are capable of achieving significant performance improvement. However, designing hardware accelerators lacks the flexibility and the productivity. Combining hardware accelerators with multiprocessor system-on-chip (MPSoC) is an alternative way to balance the flexibility, the productivity, and the performance. In this work, we present a unified hybrid OpenCL-flavor (HOpenCL) parallel programming model on MPSoC supporting both hardware and software kernels. By integrating the HOpenCL hardware IPs and software libraries, the same kernel function can execute as either hardware kernels on the dedicated hardware accelerators or software kernels on the general-purpose processors. Using the automatic design flow, the corresponding hybrid hardware platform is generated along with the executable. We use the matrix multiplication of 512×512 to examine the potential of our hybrid system in terms of performance, scalability, and productivity. The results show that hardware kernels reach more than 10 times speedup compared with the software kernels. Our prototype platform also demonstrates a good performance scalability when the number of group computation units (GCUs) increases from 1 to 6 until it becomes a memory bound problem. Compared with the hard ARM core on the Zynq 7045 device, we find that the performance of one ARM core is equivalent to 2 or 3 GCUs with software kernel implementations. On the other hand, a single GCU with hardware kernel implementation is 5 times faster than the ARM core.