gebhart/patrepeval huggingface dataset:
Serial Determinations of Absolute Plasma Volume with Indocyanine Green during Hemodialysis (2003)

Hemodynamic stability during hemodialysis depends largely on plasma volume (PV) preservation during ultrafiltration (UF). Current estimates of blood volume (BV) are indirect or involve the use of radioactive tracers, which does not allow repeated measurements during hemodialysis. Indocyanine green was used to measure PV during hemodialysis. After an initial pilot phase (phase I), PV values were determined before dialysis, repeatedly during isovolemic hemodialysis (phase II), and during stepwise UF (phase III). Absolute BV values were calculated from PV and hematocrit values. Patients were monitored for extracellular fluid volume (bioimpedance monitoring) and relative BV changes (ultrasonic monitoring). Phase I demonstrated dye stability in plasma, peak absorbance at 805 nm, and a short half-life (4.53 +/- 1.5 min). Ten milligrams of dye (2.5 mg/ml) were injected for each PV measurement. Eight plasma samples were obtained beginning 3 min after injection, at 1-min intervals, for assessment of decay characteristics. The isovolemic hemodialysis PV measurements demonstrated excellent reproducibility (r(2) = 0.98; method SD, 356 ml; mean coefficient of variation, 4.07%) and a difference of only 149 +/- 341 ml (mean +/- SD), compared with predialysis PV values (Bland-Altman method). PV values at the beginning of dialysis were significantly correlated with body surface area (r(2) = 0.82, P < 0.001) and extracellular fluid estimates (r(2) = 0.73, P < 0.001). BV prediction formulae significantly underestimated absolute BV at the start of dialysis (P < 0.0001). The findings demonstrate that this method can be used for repeated PV determinations during hemodialysis, with excellent reproducibility. It is a potential tool for further research on hemodynamic stability during UF.
Putative receptor binding sites on alphaviruses as visualized by cryoelectron microscopy. (1995)

The structures of Sindbis virus and Ross River virus complexed with Fab fragments from monoclonal antibodies have been determined from cryoelectron micrographs. Both antibodies chosen for this study bind to regions of the virions that have been implicated in cell-receptor recognition and recognize epitopes on the E2 glycoprotein. The two structures show that the Fab fragments bind to the outermost tip of the trimeric envelope spike protein. Hence, the same region of both the Sindbis virus and Ross River virus envelope spike is composed of E2 and is involved in recognition of the cellular receptor.
COE Design of Cement Stabilized Base Courses for Airfield Pavements (1991)

The U.S. Army Corps of Engineers (COE) develops design criteria, guide specifications, and other tehcnical guidance information that are used for pavement design and contract specifications preparation. Changes and new concepts introduced in the area of the design of pavements with cement stabilized base courses are discussed in this paper. Four technical manuals (TM) applicable in the design of cement stabilized base courses are considered. They are as follows: TM 5-822-4 - Soil Stabilization for Pavements; TM 5-825-2 - Flexible Pavement Design for Airfields; TM 5-8253 - Rigid Pavements for Airfields; TM 5-818-2 Pavement Design for Seasonal Frost Conditions.
Coronary thrombosis in pathogenesis of acute myocardial infarction. Histopathological study of coronary arteries in 108 necropsied cases using serial section. (1978)

An extensive histopathological study was carried out on the hearts of 108 patients with electrocardiographically proven acute myocardial infarction dying after admission to a coronary care unit. The occluded or the narrowest segments of the coronary arteries were examined at intervals of 100 mu using serial sections. Serial sectioning is important in such a study because the pathology of the lumen can vary considerably within a 2 to 3 mm segment. A high incidence (80.3%) of thrombus formation corresponding to the site of infarction was observed. These thrombi occluded the vessel lumen, were usually found proximally in the coronary arteries, and were associated with a ruptured atheromatous plaque in 90.8 per cent of cases. It is postulated that an increase of intraplaque pressure resulting from a honeycomb-like accumulation of foam cells, cholesterol clefts, and blood infiltration through the injured endothelial cells is the cause of rupture of the atheromatous plaque. This rupture into the vessel lumen may precede, and be responsible for, formation of thrombus and the onset of acute myocardial infarction.
Femtosecond pulse shaping adds a new dimension to mass spectrometry (2007)

Phase-shaped femtosecond laser pulses and mass spectrometry were implemented as a tool for improving molecular identification. We demonstrate that the specific lines in the mass spectra of several chemical warfare simulants are sensitive to the phase characteristics of the incident laser field. The deviation in the relative yield of fragment ions observed upon pulse shaping (enhancement or suppression) adds a new dimension to mass spectrometry that improves molecular identification and can be used to quantitatively analyze mixtures of isomers.
Determination of Amoebicidal Activities of Multipurpose Contact Lens Solutions by Using a Most Probable Number Enumeration Technique (2003)

Six multipurpose contact lens solutions [All-in-One, All-in-One (Light), ReNu MultiPlus, Optifree Express, Complete, and Solo-care soft] were tested for their efficacies against Acanthamoeba castellanii trophozoites and cysts by using a most probable number (MPN) technique for amoebic enumeration. Against trophozoites, All-in-One, ReNu Multiplus, and Optifree Express achieved total kill (log reduction of >3) after the manufacturer's minimum recommended disinfection time (MMRDT), with the remaining solutions failing to reach a log reduction of 1. After 24 h of exposure, all solutions proved trophozoiticidal, achieving, with the exception of Complete (log reduction of 3.13), total kill. Against cysts, All-in-One gave a log reduction of >3 within the MMRDT, with all other solutions failing to achieve a log reduction of 1. After 24 h of exposure, All-in-One achieved total kill of cysts (log reduction of 3.74), ReNu MultiPlus gave a log reduction of 3.15, and the remaining solutions reached log reductions of between 1.09 and 2.27. The MPN technique provides a simple, reliable, and reproducible method of amoebic enumeration that depends on simply establishing the presence or absence of growth on culture plates inoculated with a series of dilutions and determining the MPN of amoebae present from statistical tables. By use of this technique, two of the multipurpose solutions tested, ReNu MultiPlus and Optifree Express, demonstrated effective trophozoiticidal activities within the recommended disinfection times; however, only All-in-One proved effective against both trophozoites and cysts over the same time period. This MPN technique, which uses axenically produced trophozoites and mature, double-walled cysts, has the potential to form the basis of a national standard for amoebicidal efficacy testing of multipurpose contact lens disinfecting solutions.
The effects of cache architecture on the performance of operating systems in multithreaded processors (2002)

Multithreading is well accepted as a technique to hide latency in non-blocking cache architectures. By switching execution from a blocked thread to another, the CPU can perform useful work, while waiting for long requests to be processed by the memory hierarchy. In this paper we study four memory hierarchy organizations, and we find that the performance of the operating system, in terms of response time, greatly depends on the cache configuration and memory hierarchy. For a simple cache design, the OS response time can be below 50%, which can only be improved by increasing the cache size or associativity. We find that the best way to guarantee OS response time in multithreaded processors is to use pipelined memory, which reduces the miss penalty and thus the uncertainty in response time.
Music-Enhanced CFAR for High Frequency Over-the-Horizon Radar (2007)

To increase the number of location options for an HF surface-wave radar (HFSWR) there is significant interest in reducing the physical size of the receive array. Reducing the aperture results in a degradation of both sensitivity and azimuth information. Azimuth accuracy may be retained by the use of high-resolution methods (such as MUSIC) that have a significantly smaller beamwidth than standard beamforming. It is expected that the application of these high-resolution methods will help retain azimuth information with reduced aperture size. This paper evaluates the effects of reducing the physical aperture of the linear receive array used in HFSWR and using post-detection azimuth re-estimation by high-resolution methods to maintain azimuth resolution, accuracy, and hence tracking performance. This paper is limited to evaluating the effect of increased azimuth beamwidth and does not address the issue of reduced radar sensitivity. Data for the evaluation was obtained from an HFSWR system located at Cape Race, Newfoundland, Canada. The accuracy of the detection centroid for a full 16-element array is compared to the accuracy for a half-aperture 8-element array. It is shown that similar accuracy can be achieved from the shortened array employing the MUSIC-Enhanced CFAR compared to the full size array using the conventional CFAR processing.
The use of music in managing pain for hospitalized children (1998)

A study of the research literature indicate neurological, physiological and psychological links between music and pain. Various theories are presented to describe the effect of music on pain perception. Music therapy techniques used to alleviate pain for hospitalized children are illustrated through case studies. (author abstract)
Biodegradable electrical insulation fluids (2002)

Utilities and other users of liquid filled transformers have shown an interest in biodegradable insulating fluids as alternatives to currently available dielectric fluids. This interest is based on the low biodegradability levels of currently available dielectric fluids and the environmental concerns that could result from spills of these fluids. This paper discusses the use of vegetable oils for use in transformers. An acceptable fluid called BIOTEMP is described which has high temperature stability.
Steroid control of porphyrin and heme biosynthesis: a new biological function of steroid hormone metabolites. (1967)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
The analgesic effect of epidural nalbuphine in post surgical patients; A double blind controled study (1984)

1Department of Anesthesiology, Veteran General Hospital, Taipei, Taiwan, R.O.C. 2Harbor/UCLA Medical Center, Torrance, CA, 90509, U.S.A.
Characterization of the 35-kilodalton Treponema pallidum subsp. pallidum recombinant lipoprotein TmpC and antibody response to lipidated and nonlipidated T. pallidum antigens (1991)

The gene encoding the 35-kDa immunogenic Treponema pallidium subsp. pallidum (T. pallidum) membrane protein C, TmpC, was cloned, sequenced, and expressed in Escherichia coli. The deduced amino acid sequence carries on N-terminal signal sequence with a four-amino-acid motif, which is characteristic for bacterial lipoproteins. Metabolic labeling with radioactive palmitic acid of E. coli expressing TmpC revealed incorporation of the fatty acid into the antigen. The antigen was overproduced, purified to near homogeneity and used in an enzyme-linked immunosorbent assay (ELISA) to evaluate its potential for the serodiagnosis of syphilis. Although all sera from untreated secondary syphilis patients were reactive in this TmpC ELISA, only a minority of the serum samples from untreated patients in the primary or early latent stage of the disease contained significant anti-TmpC antibodies. To study the influence of the lipid moiety on the antigenic properties of the TmpC, TmpA, and TpD lipoproteins, plasmids encoding nonlipidated forms of these antigens were constructed. In addition, a plasmid expressing a lipidated form of the otherwise non-lipid-modified antigen TmpB was constructed. Immunization and absorption experiments with these lipidated and nonlipidated antigens showed that antibodies against the lipid moiety of lipoproteins could not be detected on immunoblots, neither in sera from infected rabbits nor in sera from animals immunized with the lipoproteins. In addition, we were unable to demonstrate cross-reactivity between antibodies against the T. pallidum lipoproteins and those reactive to the Venereal Diseases Research Laboratories test, suggesting that antibodies reactive to the Venereal Diseases Research Laboratories test are unrelated to antilipoprotein antibodies.
On the Use of 3-D Accelerometers for Road Quality Assessment (2018)

Lack of comprehensive and up-to-date information on degrading road conditions is only exacerbating the already inefficient, expensive and labor-expensive methods associated with road maintenance and repair. Among many sensing modalities that are currently being explored, MEMS accelerometers are increasingly becoming popular in the task of road quality assessment, especially in large-scale crowdsourced data gathering efforts. In this paper, recent results on the use of accelerometers for detection of road abnormalities is presented. In particular, with an emphasis on developing a low-cost yet robust road abnormality detection system, predictive effectiveness of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">features</i> generated from acceleration sensors is explored. By utilizing a signal transmission model that captures the system dynamics and low-pass filtering effects associated with vehicle suspension system, a simplified approach towards the `reconstruction' of road surface conditions from vertical acceleration measurements is presented. Furthermore, with this particular signal transmission model in place, predictive effectiveness of features derived from acceleration sensors is explored via the use of a statistical approach referred to as <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">relief algorithm</i> . The signal model and feature analysis approach is demonstrated via a <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">real-life</i> dataset.
End-to-end quality of service in multi-class service high-speed networks via optimal least weight routing (2003)

We propose the use of the optimal least weight routing (OLWR) algorithm for routing QoS flows in high-speed networks. The main principle of our algorithm is that the choice of the most appropriate route, is based on a set of parameters that estimate the impact that, the acceptance and routing decision of a call request belonging to a specific class, would have on the network and other classes of service. The performance evaluation results demonstrated that OLWR outperforms both the multi-hop least-loaded routing algorithms and the multihop most-loaded routing algorithms in terms of both revenue and carried load.
COUP‐TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction (2009)

During embryonic lymphatic development, Prox1 homeobox transcription factor is expressed in a subset of venous blood vascular endothelial cells (BECs) in which COUP-TFII orphan nuclear receptor is highly expressed. Prox1 induces differentiation of BECs into lymphatic endothelial cells (LECs) by inducing the expression of various LEC markers including vascular endothelial growth factor receptor 3 (VEGFR3). However, the molecular mechanisms of how transcriptional activities of Prox1 are regulated are largely unknown. In the present study, we show that COUP-TFII plays important roles in the regulation of the function of Prox1. In BECs and LECs, Prox1 promotes the proliferation and migration toward VEGF-C by inducing the expression of cyclin E1 and VEGFR3, respectively. Gain-of-function studies showed that COUP-TFII negatively regulates the effects of Prox1 in BECs and LECs whereas loss-of-function studies showed that COUP-TFII negatively and positively regulates Prox1 in BECs and LECs, respectively. We also show that endogenous Prox1 and COUP-TFII physically interact in LECs and that both Prox1 and COUP-TFII bind to the endogenous cyclin E1 promoter. These results suggest that COUP-TFII physically and functionally interact during differentiation and maintenance of lymphatic vessels.
Role of <i>N</i>-glycosylation for the plasma clearance of rat liver secretory glycoproteins (1989)

Conference Article| February 01 1989 Role of N-glycosylation for the plasma clearance of rat liver secretory glycoproteins VOLKER GROSS; VOLKER GROSS *Medizinische Klinik der Universität Freiburg, D-7800 Freiburg, F.R.G. Search for other works by this author on: This Site PubMed Google Scholar KLAUS STEUBE; KLAUS STEUBE †Biochemisches Institut der Universität Freiburg, D-7800 Freiburg, F.R.G. Search for other works by this author on: This Site PubMed Google Scholar THUY-ANH TRAN-THI; THUY-ANH TRAN-THI †Biochemisches Institut der Universität Freiburg, D-7800 Freiburg, F.R.G. Search for other works by this author on: This Site PubMed Google Scholar WOLFGANG GEROK; WOLFGANG GEROK *Medizinische Klinik der Universität Freiburg, D-7800 Freiburg, F.R.G. Search for other works by this author on: This Site PubMed Google Scholar PETER C. HEINRICH PETER C. HEINRICH ‡ †Biochemisches Institut der Universität Freiburg, D-7800 Freiburg, F.R.G. ‡To whom correspondence should be addressed Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: August 08 1988 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1989 Biochemical Society1989 Biochem Soc Trans (1989) 17 (1): 21–23. https://doi.org/10.1042/bst0170021 Article history Received: August 08 1988 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation VOLKER GROSS, KLAUS STEUBE, THUY-ANH TRAN-THI, WOLFGANG GEROK, PETER C. HEINRICH; Role of N-glycosylation for the plasma clearance of rat liver secretory glycoproteins. Biochem Soc Trans 1 February 1989; 17 (1): 21–23. doi: https://doi.org/10.1042/bst0170021 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Uncoiling the Modern Sino-American Relationship (2011)

We propose a biodiversity credit system for trading endangered species habitat designed to minimize and reverse the negative effects of habitat loss and fragmentation, the leading cause of species endangerment in the United States. Given the increasing demand for land, approaches that explicitly balance economic goals against conservation goals are required. The Endangered Species Act balances these conflicts based on the cost to replace habitat. Conservation banking is a means to manage this balance, and we argue for its use to mitigate the effects of habitat fragmentation. Mitigating the effects of land development on biodiversity requires decisions that recognize regional ecological effects resulting from local economic decisions. We propose Landscape Equivalency Analysis (LEA), a landscape-scale approach similar to HEA, as an accounting system to calculate conservation banking credits so that habitat trades do not exacerbate regional ecological effects of local decisions. Credits purchased by public agencies or NGOs for purposes other than mitigating a take create a net investment in natural capital leading to habitat defragmentation. Credits calculated by LEA use metapopulation genetic theory to estimate sustainability criteria against which all trades are judged. The approach is rooted in well-accepted ecological, evolutionary, and economic theory, which helps compensate for the degree of uncertainty regarding the effects of habitat loss and fragmentation on endangered species. LEA requires application of greater scientific rigor than typically applied to endangered species management on private lands but provides an objective, conceptually sound basis for achieving the often conflicting goals of economic efficiency and long-term ecological sustainability.
Synthesis and properties of perovskite BiFeO3-K0.5Na0.5NbO3 ceramics by solid-state reaction (2010)

Rhombohedrally distorted perovskite BiFeO3–K0.5Na0.5NbO3 ceramics with ferroelectricity and ferromagnetism were synthesized by solid-state reaction. The effect of K0.5Na0.5NbO3 content on the crystal structure, electrical and magnetic properties of a BiFeO3–K0.5Na0.5NbO3 system was examined with a view to achieving multiferroic BiFeO3-based ceramics. Perovskite BiFeO3–K0.5Na0.5NbO3 single phase was obtained by formation of solid solution with K0.5Na0.5NbO3, whereas pure BiFeO3 ceramics contained a small amount of a second phase, such as Bi36Fe2O57. The crystallographic symmetry of BiFeO3–K0.5Na0.5NbO3 changed from rhombohedral to cubic when the content of K0.5Na0.5NbO3 exceeded 15 mol %. The rhombohedrally distorted BiFeO3–K0.5Na0.5NbO3 showed a high Curie temperature (>770°C) and weak ferromagnetism at room temperature. Dielectric properties of the resultant ceramics were improved by controlling the amount of Mn doping to facilitate ferroelectric measurements.
[Impact of depth and moisture to diesel degradation in sand layer of vadose zone]. (2011)

Through the experiment simulated sand columns, the biodegradation characteristics of diesel in sand layers (including fine sand, medium sand and coarse sand) with different depths and moisture contents were studied. The results show that the depth and moisture content of medium are important factors in affecting the efficiency of diesel degradation. In the same medium conditions, the higher moisture content of the medium, the higher biological activity, and biological degradation efficiency of diesel are observed. The nature of medium affects the efficiency of diesel degradation in vadose zone. The finer particles of the medium, the higher ability of diesel degradation is. It is expressed as: fine sand > medium sand > coarse sand. Volatilization and biodegradation are important factors in affecting natural attenuation of diesel in vadose zone.
A ring-closing metathesis-mediated route to novel enantiopure conformationally restricted cyclic amino acids (2000)

A combination of palladium-catalysed N,O-acetal formation, ruthenium-catalysed ring-closing metathesis and N-sulfonyliminium ion-mediated C–C bond formation constitutes an efficient and versatile route to a set of enantiomerically pure 2,6-disubstituted unsaturated pipecolic acid derivatives.