gebhart/patrepeval huggingface dataset:
Properties of polythiourethanes prepared by thiol–isocyanate click reaction (2017)

ABSTRACT Polythiourethane networks with systematic compositional variations of thiol [ethoxylated trimethylol‐propane tri(3‐mercapto‐propionate), ETTMP1300 and pentaerythritol tetra(3‐mercapto‐propionate), PETMP] and isophorone diisocyanate (IPDI), i.e., IPDI/ETTMP1300/PETMP = 100/100/0, 100/80/20, 100/60/40, 100/40/60, 100/20/80, and 100/0/100, were prepared by base catalyzed thiol–isocyanate click type reaction where the base catalyst (tributylamine, TBA) was photolytically generated using photolatent amine (TBA·tetraphenylborate salt, TBA·HBPh 4 ). The kinetics of the polythiourethane network formation investigated using real‐time infrared indicates that the thiol–isocyanate coupling reaction was successfully triggered photolytically and the conversion of both thiol and isocyanate reached near 100% in a matter of minutes. The T g of the polythiourethane networks progressively increases (–8 to 143 °C by DMTA) as a function of the PETMP content due to the higher extent of crosslinks, also resulting in enhanced rubbery modulus. Very narrow full width at half maximum (15–28 °C) of tan δ peak was obtained for all six sets of polythiourethane networks, which is induced by the highly uniform and dense structures of thiol‐based polymeric network. Energy damping performance of polythiourethane networks measured by nondestructive impact testing exhibited remarkably high (∼95%) and the relationship with temperature was in accordance with tan δ peak. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46070.
Thread-Specific Data and Signal Handling in Multi-Threaded Applications (1997)

This second part of a series on Multi-threading deals with how to use C programs with one of the POSIX packages available for Linux to handle signals and concurrent threads
Localization of segments essential for polymerization and for calcium binding in the .gamma.-chain of human fibrinogen (1986)

We have isolated an intermediate plasmic degradation product, D2, of fibrinogen that does not inhibit the polymerization of fibrin monomer but does bind Ca2+. Fibrinogen was digested to a limited extent with plasmin in the presence of Ca2+, and a "large" fragment D (fragment D1A) was isolated with a gamma-chain remnant consisting of residues 63-411. Fragment D1A was digested further in the presence of Ca2+, yielding fragment D1 (with its gamma-chain containing residues 86-411). The digestion of fragment D1 [in the presence of ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) to complex Ca2+] led to a gradual shortening of the carboxyl-terminal portion of the gamma-chain. Fragment D2 (with its gamma-chain containing residues 86-335/356) was isolated from an intermediate digest in the presence of EGTA. The Lys-338-Cys-339 peptide bond of the gamma-chain is intact in this preparation of D2, even though it is split in the isolated peptide gamma303-355 (with an intact disulfide bond at Cys-326-Cys-339). Fragment D2 does not interfere with the polymerization of fibrin monomer, whereas fragment D1 is a potent inhibitor of this polymerization. We conclude that the gamma-chain segment 356/357-411, present in fragment D1 but absent from fragment D2, is essential for maintenance of a polymerization site located in the outer (D) nodule of fibrinogen. This segment (356/357-411) is longer than two shorter ones reported earlier [Olexa, S.A., & Budzynski, A. Z. (1981) J. Biol. Chem. 256, 3544-3549; Horwitz, B.H., Váradi, A., & Scheraga, H.A. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 5980-5984]; the data for the earlier reports are reinterpreted here. Finally, fragment D2 possesses a single Ca2+ binding site, as revealed by equilibrium dialysis binding studies. Since fragment D3 (with its gamma-chain containing residues 86-302) fails to bind Ca2+, we conclude that segment gamma 303-355/356 plays a crucial role in Ca2+ binding.
Stabilizing the Frequency of Hysteretic Current-Mode DC/DC Converters (1987)

A systematic investigation of methods to stabilize the operating frequency of hysteretic current-mode dc/dc converters through control of the current hysteresis is presented. The control laws for every power stage are derived, and two open-loop and two closed-loop circuits are shown and analized in detail. The interaction of the major voltage control loop and the frequency control circuitry is also investigated for buck converters. It is shown that, if the average inductor current is programmed, the two mechanisms are independent, while if the peak inductor current is programmed, they are not. The frequency control circuitry in the latter case decreases the phase margin of the voltage control loop and can lead to instability. Simple circuits are developed to implement the superior average inductor-current programming. As a consequence of being controlled via the current hysteresis, the operating frequency cannot be stabilized in the light mode, where VO/RL < IH/2. In the special case, where the frequency of the converter is stabilized by a phase-locked loop, a method and circuit are shown to solve this problem and achieve constant frequency operation at any load.
Wave-packet dynamics in a cyanine dye molecule excited with femtosecond chirped pulses (2000)

Femtosecond vibrational wave-packet dynamics in a cyanine molecule is observed to be strongly dependent on the chirp direction of the excitation pulse. The slow-decay component associated with an oscillatory structure, which corresponds to the excited-state lifetime and a vibrational mode of 160±10 cm−1, respectively, is measured by the femtosecond time-resolved transmission spectroscopy. The excited-state population is substantially decreased and enhanced in the cases of negatively chirped (NC) and positively chirped (PC) excitations, respectively. A quantum mechanical calculation by means of the split operator scheme is performed to reproduce the wave-packet propagation after the chirped pulse excitation. The calculation shows that the spatial distribution of the wave packet for the NC case is narrower than that for the PC case during the excitation, and that the overlap integral between the excited- and ground-state wave packets determines the efficiency of the population dumping.
Improved sensitivity and security for distribution bus and feeder relays (2002)

Traditional protective equipment does not adapt readily to distribution system reconfiguration. If new settings are needed they have to be manually changed: there are no settings in reserve. The time to make or enter and test new settings slows down emergency responses and risks human error. Sometimes relay settings are not changed for emergency or abnormal switching, because it takes too long or is too difficult. System protection is compromised. Multiple setting groups, negative-sequence overcurrent elements, alarm-directed backup, and time-overcurrent element reset options improve the fault detection sensitivity and system security provided by advanced microprocessor-based distribution bus and feeder relays.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Load Balancing in the Lp Norm (1995)

In the load balancing problem, there is a set of servers, and jobs arrive sequentially. Each job can be run on some subset of the servers, and must be assigned to one of them in an online fashion. Traditionally, the assignment of jobs to servers is measured by the L1 norm; in other words, an assignment of jobs to servers is quantified by the maximum load assigned to any server. In this measure the performance of the greedy load balancing algorithm may be a logarithmic factor higher than optimal [3]. In many applications, the L1 norm is not a suitable way to measure how well the jobs are balanced. If each job sees a delay that is proportional to the number of jobs on its server, then the average delay among all jobs is proportional to the sum of the squares of the numbers of jobs assigned to the servers. Minimizing the average delay is equivalent to minimizing the Euclidean (or L 2 ) norm. For any fixed p, 1 p ! 1, we show that the greedy algorithm performs within a constant factor of...
Hybrid ASIC/FPGA System for Fully Automatic Stereo-to-Multiview Conversion Using IDW (2015)

Recently, multiview autostereoscopic dis-plays (MADs), which enable a limited glasses-free 3D experience, have become commercially available. The main problem of MADs is that they require several (typically eight or nine) views, while most of the 3D video content is in stereoscopic 3D today. In order to bridge this gap, the research community started to devise automatic multiview synthesis (MVS) methods. These algorithms require real-time processing and should be portable to end-user devices to develop their full potential. To this end, we revisit an algorithmic solution based on image domain warping (IDW) and devise a hardware architecture of a complete synthesis pipeline, provide insights into where the computationally challenging parts are, and present implementation results of a hybrid field programmable gate array/application-specific integrated circuit prototype, which is the first hardware implementation of a complete IDW-based MVS system. Based on these results, we also estimate the complexity and energy efficiency of a fully integrated solution in 65- and 28-nm CMOS technology and show that a full-high-definition real-time solution on a single chip is within reach. The proposed architecture could be used as a coprocessor in a system-on-chip targeting 3D TV sets, thereby enabling efficient content generation with limited user interaction (e.g., depth range adjustment) in real time.
Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes (2009)

Several species of African trypanosomes cause fatal disease in livestock, but most cannot infect humans due to innate trypanosome lytic factors (TLFs). Human TLFs are pore forming high-density lipoprotein (HDL) particles that contain apolipoprotein L-I (apoL-I) the trypanolytic component, and haptoglobin-related protein (Hpr), which binds free hemoglobin (Hb) in blood and facilitates the uptake of TLF via a trypanosome haptoglobin-hemoglobin receptor. The human-infective Trypanosoma brucei rhodesiense escapes lysis by TLF by expression of serum resistance-associated (SRA) protein, which binds and neutralizes apoL-I. Unlike humans, baboons are not susceptible to infection by T. b. rhodesiense due to previously unidentified serum factors. Here, we show that baboons have a TLF complex that contains orthologs of Hpr and apoL-I and that full-length baboon apoL-I confers trypanolytic activity to mice and when expressed together with baboon Hpr and human apoA-I, provides protection against both animal infective and the human-infective T. brucei rhodesiense in vivo. We further define two critical lysines near the C terminus of baboon apoL-1 that are necessary and sufficient to prevent binding to SRA and thereby confer resistance to human-infective trypanosomes. These findings form the basis for the creation of TLF transgenic livestock that would be resistant to animal and human-infective trypanosomes, which would result in the reduction of disease and the zoonotic transmission of human infective trypanosomes.
[The clinico-morphological diagnosis of cancer of the sweat glands]. (1990)

Comprehensive clinical, morphologic, and ultrastructural studies of 12 cases with various forms of carcinoma of the sweat glands permitted distinguishing the clinical nodular and papular-cystic forms. Histologically malignant analogs of benign tumors, primary adenocarcinomas, and unclassified tumors are distinguished. The histogenetic appurtenance of the tumors of the latter group may be identified only by ultrastructural studies that help detect a number of organ specificity signs. Electron microscopy used in the diagnosis of poorly differentiated tumors of the skin helps carry out adequate therapeutic strategy and permitted a better validated prediction.
Syndecan Binding Protein (SDCBP) Is Overexpressed in Estrogen Receptor Negative Breast Cancers, and Is a Potential Promoter for Tumor Proliferation (2013)

Our results suggested that SDCBP played an important role in tumor growth of ER-negative BCas. In these tumors where the estrogen signaling pathway is not available, SDCBP probably contribute to tumor growth through an alternative signaling pathway by promoting tumor cells passing the G1/S checkpoint into the cell cycle. Suppression of SDCBP expression may have its potential to become a targeted therapy for ER-negative BCas.
Three-dimensional tracking and behaviour monitoring of multiple fruit flies (2012)

The increasing interest in the investigation of social behaviours of a group of animals has heightened the need for developing tools that provide robust quantitative data. Drosophila melanogaster has emerged as an attractive model for behavioural analysis; however, there are still limited ways to monitor fly behaviour in a quantitative manner. To study social behaviour of a group of flies, acquiring the position of each individual over time is crucial. There are several studies that have tried to solve this problem and make this data acquisition automated. However, none of these studies has addressed the problem of keeping track of flies for a long period of time in three-dimensional space. Recently, we have developed an approach that enables us to detect and keep track of multiple flies in a three-dimensional arena for a long period of time, using multiple synchronized and calibrated cameras. After detecting flies in each view, correspondence between views is established using a novel approach we call the 'sequential Hungarian algorithm'. Subsequently, the three-dimensional positions of flies in space are reconstructed. We use the Hungarian algorithm and Kalman filter together for data association and tracking. We evaluated rigorously the system's performance for tracking and behaviour detection in multiple experiments, using from one to seven flies. Overall, this system presents a powerful new method for studying complex social interactions in a three-dimensional environment.
Synthesis of chiral .alpha.-alkyl phenethylamines via organometallic addition to chiral 2-aryl-1,3-oxazolidines (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of chiral .alpha.-alkyl phenethylamines via organometallic addition to chiral 2-aryl-1,3-oxazolidinesMing Jung Wu and Lendon N. PridgenCite this: J. Org. Chem. 1991, 56, 3, 1340–1344Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/jo00003a087https://doi.org/10.1021/jo00003a087research-articleACS PublicationsRequest reuse permissionsArticle Views721Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Signaling Gradients during Paraxial Mesoderm Development (2009)

The sequential formation of somites along the anterior-posterior axis is under control of multiple signaling gradients involving the Wnt, FGF, and retinoic acid (RA) pathways. These pathways show graded distribution of signaling activity within the paraxial mesoderm of vertebrate embryos. Although Wnt and FGF signaling show highest activity in the posterior, unsegmented paraxial mesoderm (presomitic mesoderm [PSM]), RA signaling establishes a countergradient with the highest activity in the somites. The generation of these graded activities relies both on classical source-sink mechanisms (for RA signaling) and on an RNA decay mechanism (for FGF signaling). Numerous studies reveal the tight interconnection among Wnt, FGF, and RA signaling in controlling paraxial mesoderm differentiation and in defining the somite-forming unit. In particular, the relationship to a molecular oscillator acting in somite precursors in the PSM-called the segmentation clock-has been recently addressed. These studies indicate that high levels of Wnt and FGF signaling are required for the segmentation clock activity. Furthermore, we discuss how these signaling gradients act in a dose-dependent manner in the progenitors of the paraxial mesoderm, partly by regulating cell movements during gastrulation. Finally, links between the process of axial specification of vertebral segments and Hox gene expression are discussed.
ZYDG2, a Potent, Selective, and Safe GPR40 Agonist for Treatment of Type 2 Diabetes (2018)

GPR40 is a G-protein-coupled receptor predominantly expressed in pancreatic β-cells. Agonists of GPR40 are known to stimulate insulin secretion and reduces circulating glucose levels in a glucose-dependent manner. TAK-875, a GPR40 small molecule agonist developed by Takeda Pharmaceuticals showed antidiabetic efficacy in animals and humans, but its development was terminated in phase 3 due to adverse liver effects. ZYDG2 is a safer GPR40 agonist that has shown desirable profile in preclinical studies. ZYDG2 was identified as a potent and selective agonist for GPR40, exhibiting EC50 of 13 nM and 41 nM for hGPR40, in HEK-293 cell-based Ca2+ mobilization assay and IP1 ELISA assays respectively. It increased insulin secretion and showed dose-dependent improvement in glucose tolerance test in n-STZ Wistar rats, DIO mice and db/db mice. It also showed anti-hyperglycemic effects in rats unresponsive to sulfonylureas. No tachyphylaxis was observed after repeated administration for 15 weeks in n-STZ rats. ZYDG2 showed glucose-stimulated insulin secretion as revealed by significant increase in glucose infusion rate in hyperglycemic clamp study using SD rats. ZYDG2 treatment was associated with significant rise in plasma total GLP1 levels in nondiabetic and diabetic animal models which was not observed in case of TAK-875. Since TAK-875 was terminated due to hepatotoxicity associated with bile acid transporter inhibition, this aspect was studied in details. TAK-875 inhibited the hBSEP and hMRP2 at efficacy concentrations whereas ZYDG2 does not show any inhibition (up to 300 µM) for hBSEP and hMRP2. TAK-875 also showed significantly increased cholic acid levels in Sprague Dawley rat which was not shown by ZYDG2. The maximum tolerated dose for ZYDG2 was 2000 mg/kg and 28 days NOAEL was 300 mg/kg. This clearly demonstrates that ZYDG2 has a great potential to become a safe and effective candidate for treatment of type 2 diabetes. Disclosure M.R. Jain: None. S.R. Giri: None. C.J. Trivedi: None. B.B. Bhoi: None. A.C. Rath: None. R.M. Rathod: None. R. Sundar: None. D. Bandyopadhyay: None. R. Ramdhave: None. G.D. Patel: None. B.K. Srivastava: None. R.C. Desai: None.
A new family of polymerases related to superfamily A DNA polymerases and T7-like DNA-dependent RNA polymerases (2008)

Using sequence profile methods and structural comparisons we characterize a previously unknown family of nucleic acid polymerases in a group of mobile elements from genomes of diverse bacteria, an algal plastid and certain DNA viruses, including the recently reported Sputnik virus. Using contextual information from domain architectures and gene-neighborhoods we present evidence that they are likely to possess both primase and DNA polymerase activity, comparable to the previously reported prim-pol proteins. These newly identified polymerases help in defining the minimal functional core of superfamily A DNA polymerases and related RNA polymerases. Thus, they provide a framework to understand the emergence of both DNA and RNA polymerization activity in this class of enzymes. They also provide evidence that enigmatic DNA viruses, such as Sputnik, might have emerged from mobile elements coding these polymerases.
Improved Optical Enrichment of SWNTs through Extraction with Chiral Nanotweezers of 2,6-Pyridylene-Bridged Diporphyrins (2007)

Chiral single-walled carbon nanotubes (SWNTs) have left- and right-handed helical structures (M and P, respectively, according to the IUPAC nomenclature). In this report, optically active SWNTs were obtained through preferential extraction of (M)- or (P)-SWNTs with 2,6-pyridylene-bridged chiral diporphyrins 1. In the circular dichroism (CD) spectra, the SWNTs extracted with 1 exhibit much larger intensity than those extracted with 1,3-phenylene-bridged chiral diporphyrins 2, indicating an improved chiral discrimination ability of 1. In particular, (6,5)-SWNTs display the most intensified CD signals among the SWNTs extracted with 1. In addition, the SWNT extraction ability of 1 has been shown to be considerably enhanced in comparison to 2. These improved discrimination and extraction abilities of 1 are attributed to the formation of its more stable SWNT complex. Computer-calculated energy minimized structures for 1:(6,5)-SWNT complexes show that (R)- and (S)-1 form complexes preferentially with (M)- and (P)-(6,5)-SWNTs, respectively. These calculations also predict that the 1:(6,5)-SWNT complex is approximately 1.6 kcal mol-1 more stable than the corresponding complex of 2, accounting for the improved abilities of 1 in the chiral discrimination and extraction.
Blind channel estimation by least squares smoothing (2002)

A linear least squares smoothing approach is proposed for the blind channel estimation. It is shown that the single-input multiple-output moving average process has the property that the error sequence of the least squares smoother, under certain conditions, uniquely determines the channel impulse response. The relationship among the dimension of the observation space, channel order and smoothing delay is presented. A new algorithm for channel estimation based on the least squares smoothing is developed. The proposed approach has the finite-sample convergence property in the absence of the channel noise. It also has a structure suitable for recursive implementations.
Gravitational field maps and navigational errors [unmanned underwater vehicles] (2002)

Gravitational field maps are used to correct navigational errors that tend to accumulate in some navigational systems presently in use on unmanned underwater vehicles (UUVs). Two essential elements of such a system are an algorithm to calculate field maps from sparsely and irregularly sampled measured field data and an algorithm to match locally measured field values to an a priori field map. A kriging algorithm is used to calculate a variety of field maps from both simulated and measured field data that vary in resolution and in the density of data used to calculate the maps. Then, navigational errors are simulated and a novel map-matching algorithm is used with the various field maps to assess both the utility of the map-matching algorithm and the effect of map resolution and the density of measured data on the accuracy of the navigational solution. It is shown that although the accuracy of the navigational solution depends on the resolution of the field map, the number of local field samples along the UUV path, the location of the UUV path on the field map and the initial navigation errors, that a kriging algorithm may be used with sparse arrays of measured gravitational-field data.