gebhart/patrepeval huggingface dataset:
Selective Histamine Piezoelectric Chemosensor Using a Recognition Film of the Molecularly Imprinted Polymer of Bis(bithiophene) Derivatives (2009)

A histamine piezoelectric (acoustic) sensor using a molecularly imprinted polymer (MIP) film has been devised and tested. The sensor comprises an electrodeposited MIP film as the recognition element and a 10 MHz AT-cut shear-thickness-mode bulk-acoustic-wave quartz crystal resonator with Pt film electrodes as the signal transducer. Preparation of the sensing film involved two consecutive electrochemical polymerizations, performed under cyclic voltammetric conditions, with the use of a supporting electrolyte of 0.1 M tetra-n-butylammonium perchlorate in acetonitrile. First, a poly(bithiophene) barrier film was deposited by electropolymerization on the Pt/quartz resonator to prevent histamine electro-oxidation and avoid possible contamination of the Pt electrode surface. Next, the histamine-templated MIP film was deposited by electropolymerization on top of this barrier film. For that purpose, two functional monomers of bis(bithiophene) derivatives, i.e., one bearing the 18-crown-6 and the other dioxoborinane substituent, were copolymerized in the presence of the histamine template. The consecutive growth of both these overlaid films was monitored with an electrochemical quartz crystal microbalance (EQCM). Subsequently, the histamine was extracted from MIP with 0.01 M NaOH for 12 h. The UV-vis and X-ray photoelectron spectroscopic measurements confirmed the completeness of the removal of the histamine template from the MIP film. The analytical performance of the chemosensor was assessed under flow injection analysis (FIA) conditions using the carrier 0.5 M HEPES buffer (pH = 7.5) solution and the piezoelectric microgravimetry detection at QCM. The negative peaks of resonant frequency linearly decreased with the increase of the histamine concentration in the range 10-100 mM for 150 microL/min flow rate, and 100 microL volume of the injected sample. The sensitivity of the chemosensor (0.33 Hz/mM) was more than twice as that of the chemosensor without the poly(bithiophene) barrier film (0.15 Hz/mM). The chemosensor performance was superior for selective histamine recognition if the poly(bithiophene) barrier film thickness exceeded 200 nm. The chemosensor discriminated histamine from functionally or structurally similar compounds, such as dopamine, tryptamine, and imidazole. Stability constants of the affinity complexes of MIP and analyte or the interfering agent were determined from kinetic studies. For the MIP-histamine complex, the stability constant thus evaluated was equal to 57.0 M(-1) being much higher than those for the MIP-tryptamine and MIP-dopamine complexes determined to be 10.7, and 6.4 M(-1), respectively. The concentration limit of detection was as low as 5 nM histamine if the carrier solution flow rate was as low as 35 microL/min and the injection sample volume as large as 1 mL.
Reduced field‐of‐view MRI using outer volume suppression for spinal cord diffusion imaging (2007)

A spin-echo single-shot echo-planar imaging (SS-EPI) technique with a reduced field of view (FOV) in the phase-encoding direction is presented that simultaneously reduces susceptibility effects and motion artifacts in diffusion-weighted (DW) imaging (DWI) of the spinal cord at a high field strength (3T). To minimize aliasing, an outer volume suppression (OVS) sequence was implemented. Effective fat suppression was achieved with the use of a slice-selection gradient-reversal technique. The OVS was optimized by numerical simulations with respect to T(1) relaxation times and B(1) variations. The optimized sequence was evaluated in vitro and in vivo. In simulations the optimized OVS showed suppression to <0.25% and approximately 3% in an optimal and worst-case scenario, respectively. In vitro measurements showed a mean residual signal of <0.95% +/- 0.42 for all suppressed areas. In vivo acquisition with 0.9 x 1.05 mm(2) in-plane resolution resulted in artifact-free images. The short imaging time of this technique makes it promising for clinical studies.
Polymerization of β-Ethynylnaphthalene (1971)

Abstract Poly (β-ethynylnaphthalene), which has not been previously prepared and characterized in detail, was prepared with a Ziegler-Natta type catalyst. The polymer is reddish in color, soluble in aromatic solvents, and gives a positive color test for conjugation with antimony trichloride. The polymer has a molecular weight of up to 2091. Its IR and W spectroscopic characteristics are in accord with a modified conjugated polyene structure. It is thermally stable up to 470°, and probably partially crystalline.
A cylindrical coding tube for 8-digit code (1963)

The cylindrical coding tube discussed in this paper has been designed for converting a sampled analog signal into a digital signal of reflected binary (Gray) code. The physical principle of the tube is one of electron-optical image formation in a coaxially symmetrical electric field, similar to 45°-focusing in a homogeneous field. This principle leads to a minimum of image errors. The voltages applied to the tube remain below 250 volts, the control voltage being smaller than 65 volts. The current pulses are decoupled on eight discrete collectors. The signal sampling frequency may go up to 10 Mc and higher. The tube is relatively sturdy in its physical construction, the cathode being designed for a long life expectancy. The tube assembly is 65 mm in diameter, 250 mm long, and has a weight of less than 300 gms.
Marital Status as an Independent Predictor of Event-Free Survival of Patients With Heart Failure (2009)

Patients with a spouse had longer event-free survival than nonmarried patients did, even in the context of depressive symptoms.
Genetic characterization of hadad, a mutant disrupting female gametogenesis in Arabidopsis thaliana. (1997)

The plant life cycle alternates between a diploid and a
haploid generation, the spore-producing sporophyte and
the gamete-producing gametophyte. Unlike in animals,
where meiotic products differentiate directly into gametes,
the haploid spores of plants divide mitotically to
form a multicellular haploid organism. The differentiation
of gametes occurs later in the development of the gametophyte.
Noise characteristics of GaAs-AlGaAs heterojunction punch-through phototransistors (2001)

Novel GaAs-AlGaAs heterojunction phototransistors with a /spl delta/-doped base have been fabricated. Very high gain and low output noise have been measured. The measured noise is composed of shot noise associated with collector quiescent bias current and amplified shot noise due to collector leak current for nonpassivated devices. The high gain and low intrinsic noise characteristics of these transistors make them very promising in weak light detection.
Waste-to-Energy Residues: The Search for Beneficial Uses (2004)

In the U.S., about 28.5 million tons of municipal solid waste are combusted annually in waste-to-energy facilities that generate 25–30% of ash by weight of the MSW feed. Since some residues were found to contain high levels of lead and cadmium prior to the 1990s, they were commonly associated with environmental pollution. However, for the last years nearly all ash samples have been tested non-hazardous. Research on the beneficial use of combustion residue has been conducted for the past few decades yet the actual ash reuse rate in the U.S. has remained close to 10%. Currently most of the ash is landfilled at considerable cost to the waste-to-energy industry. A consortium of researchers at Columbia University, the State University of New York at Stony Brook, Temple University, and other institutions seeks to develop and to advance the beneficial uses of combustion residues, such as in construction materials or remediation of contaminated abandoned mines and brownfields. This paper describes the search for beneficial use applications and provides an overview of the first year of this consortium.
Karenitecin (bnp1350) and flavopridol as radiosensitizers in malignant glioma (2016)

The poor prognosis of malignant glioma patients highlights the need to develop low toxicity, tumor specific agents with the ability to synergize with proven efficacious treatment modalities, e.g., ionizing irradiation. This paper investigates the potential of BNP1350 (karenitecin), a topoisomerase I-targeting anticancer agent, and flavopridol a cyclin-dependent kinase inhibitor as radiosensitizers at clinically relevant doses in glioblastoma cell lines. A clonogenic survival and apoptosis assays were performed to test the effect of karenitecin (0.1 nM to 10 nM), flavopridol, (50 nM to 500 nM), radiation (1 Gy to 5.5 Gy) and a combination of radiation and karenitecin or radiation and flavopridol on the glioma cell lines T986 and M059K. Cells were stained for cyclins B and D using antibodies followed by flow cytometry. Propidium Iodide staining was used to reveal the various phases of the cell cycle; cyclin staining in the G0/G1 and G2/M phase of the cell cycle was estimated as the Mean Fluorescence Intensity (MFI) after subtracting the MFI recorded by the isotype controls. Results demonstrated that in irradiated cells, pretreatment with karenitecin induced apoptosis, a transient arrest in the G2/M phase of the cell cycle and increased the expression of cyclin B1. Flavopridol treatment also induced apoptosis and a transient block in the G2/M phase of the cell cycle. The combined effects of karenitecin and flavopridol displayed synergistic effects. The unique radiosensitizing activity of orally administrable karenitecin and flavopridol is consistent with continued investigation of these compounds preclinically, as well as in the clinical setting.
Batch screening of commercial serial flash-memory integrated circuits for low-temperature applications (2015)

We present comprehensive results on the experimentally measured performance of commercial serial flash-memory integrated circuits (ICs) over a wide temperature range (−196 °C to 25 °C). We also address endurance issues because our intended low-temperature application is electronics related to long-term storage of biological material. We compared six batches of flash-memory ICs, manufactured between 2007 and 2012. Test results reveal a batch-to-batch variation of the pass rate. Typically, programming times increase by a factor of 4–6 at −196 °C. The practical relevance of our results is discussed.
HARDWARE-IN-THE-LOOP TESTING OF THE V-22 FLIGHT CONTROL SYSTEM USING PILOTED SIMULATION (1989)

1.0 ABSTRACT The V-22 Osprey tilt rotor aircraft is capable of a wide range of flight conditions ranging from low speed helicopter to high speed airplane mode. The V-22 will be the first production VSTOL aircraft with a full-authority, digital, fly-by-wire flight control system. Various means of testing and evaluating this system have been developed to ensure the safety and integrity of the vehicle. This paper describes the development af a test facility which provides the capability to perform piloted simulation with the V-22 flight control system hardware and software in the loop. Results of piloted handling qualities and failure testing studies involving the as-built flight control system are also presented. List of Acronyms
Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). (2013)

8008 Background: Human lung cancer expresses high levels of PD-L1, which may inhibit anti-cancer immune responses. MPDL3280A, a human monoclonal Ab containing an engineered Fc-domain designed to optimize efficacy and safety, targets PD-L1, blocking PD-L1 from binding its receptors, including PD-1 and B7.1. Methods: Pts with squamous or nonsquamous NSCLC received MPDL3280A IV q3w at doses between 1-20 mg/kg in a Ph I expansion study. Pts were treated for up to 1 y. Objective response rate (ORR) was assessed by RECIST v1.1. Reported ORR includes u/cCR and u/cPR. Results: As of Jan 10, 2013, 53 NSCLC pts were evaluable for safety and treated at doses of ≤1 (n=2), 10 (n=10), 15 (n=19) and 20 mg/kg (n=22). Pts had a median age of 61 y (range 24-83 y), 98% were PS 0-1, 89% had prior surgery and 55% had prior radiotherapy. 98% of pts received prior systemic therapy. Pts received treatment for a median duration of 106 days (range 1-324) of MPDL3280A. The incidence of all G3/4 AEs, regardless of attribution, was 34%, including pericardial effusion (6%), dehydration (4%), dyspnea (4%) and fatigue (4%). No G3-5 pneumonitis or diarrhea was reported. 37 NSCLC pts enrolled prior to Jul 1, 2012, were evaluable for efficacy. RECIST responses were observed at dose levels between 1 and 20 mg/kg, with all responses ongoing or improving. An ORR of 24% (9/37) was observed in pts with squamous and nonsquamous histologies, including several with rapid tumor shrinkage. Additional pts had delayed responses after apparent radiographic progression (not included in the ORR). The 24-week PFS was 48%. Analysis of biomarker data from archival tumor samples demonstrated a correlation between PD-L1 status and efficacy. Pts who were PD-L1 tumor status–positive showed an ORR of 100% (4/4) and a PD rate of 0% (0/4), while pts who were PD-L1 tumor status–negative showed an ORR of 15% (4/26) and a PD rate of 58% (15/26). Updated data will be presented. Conclusions: Treatment with MPDL3280A was well tolerated, with no pneumonitis-related deaths. Rapid and durable responses were observed. PD-L1 tumor status correlated with response to MPDL3280A. Clinical trial information: NCT01375842.
Permeability-controllable membranes. 9. Electrochemical redox-sensitive gate membranes of polypeptide films having ferrocene groups in side chains (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPermeability-controllable membranes. 9. Electrochemical redox-sensitive gate membranes of polypeptide films having ferrocene groups in side chainsYoshio Okahata and Kazuya TakenouchiCite this: Macromolecules 1989, 22, 1, 308–315Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ma00191a056https://doi.org/10.1021/ma00191a056research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Leakage-Aware Energy-Efficient Scheduling of Real-Time Tasks in Multiprocessor Systems (2006)

This work targets energy-efficient scheduling of periodic real-time tasks over multiple DVS processors with the considerations of power consumption due to leakage current. A polynomial-time algorithm with a 1.283 approximation bound is proposed when the overheads in turning on/off a processor are negligible. When the overheads are non-negligible, we develop polynomial-time algorithms with a 2 approximation bound. A series of simulation experiments was done for the performance evaluation of the proposed algorithms. The simulation results show that the proposed algorithms could derive schedules very close to optimal solutions.
A Novel Pathway to PbSe Nanowires at Room Temperature (1998)

One-dimensional (1D) structures with nanometer diameter are expected to have remarkable properties that are in principle tunable by varying the diameter and chirality. Most previous research on 1D materials concentrated on carbon-based nanomaterials and require extreme preparation conditions. Here the authors report a novel route to PbSe nanowires (see Figure) under mild conditions at room temperature.
Learning a Hierarchical Embedding Model for Personalized Product Search (2017)

Product search is an important part of online shopping. In contrast to many search tasks, the objectives of product search are not confined to retrieving relevant products. Instead, it focuses on finding items that satisfy the needs of individuals and lead to a user purchase. The unique characteristics of product search make search personalization essential for both customers and e-shopping companies. Purchase behavior is highly personal in online shopping and users often provide rich feedback about their decisions (e.g. product reviews). However, the severe mismatch found in the language of queries, products and users make traditional retrieval models based on bag-of-words assumptions less suitable for personalization in product search. In this paper, we propose a hierarchical embedding model to learn semantic representations for entities (i.e. words, products, users and queries) from different levels with their associated language data. Our contributions are three-fold: (1) our work is one of the initial studies on personalized product search; (2) our hierarchical embedding model is the first latent space model that jointly learns distributed representations for queries, products and users with a deep neural network; (3) each component of our network is designed as a generative model so that the whole structure is explainable and extendable. Following the methodology of previous studies, we constructed personalized product search benchmarks with Amazon product data. Experiments show that our hierarchical embedding model significantly outperforms existing product search baselines on multiple benchmark datasets.
Considerations for the Thermal Modeling of Lithium-Ion Cells for Battery Analysis (2016)

Recent well-publicized events involving lithium-ion batteries in laptops, electric cars, commercial aircraft and even hover boards have raised concerns regarding thermal runaway -- a phenomenon in which stored energy in a cell is rapidly released as heat along with vented effluents. If not properly managed, testing has shown that thermal runaway in a single cell can propagate to other cells in a battery and may lead to a potentially catastrophic event. Lithium-ion batteries are becoming more widely used in a number of human-rated extravehicular activity (EVA) space applications on the International Space Station. Thermal modeling in support of thermal runaway propagation mitigation in the Lithium-ion Rechargeable EVA Battery Assembly (LREBA) and the Lithium-on Pistol Grip Tool (LPGT) was pursued to inform design decisions and to understand the results of extensive development testing with the goal of enhancing safety. A correct representation of thermal runaway in battery-level thermal models requires an understanding of internal cell triggering mechanisms, heat transfer mechanisms through the cell wall, an accounting of energy transport through vented gases and effluents and proper consideration of heat transfer mechanisms within the battery. Development and refinement of internal cell multi-physics models provided heating profiles used for a simplified cell thermal network representation. A collection of simplified cells was used to formulate battery-level models of, both, the LREBA and LPGT battery configurations. Limited correlation of these models was performed using test data. An assessment of heat transport via vented gases was performed using computational fluid dynamics (CFD). Use of the models in conjunction with testing led to design enhancements for, both, the LREBA and LPGT configurations. These thermal-runaway severity-reduction measures are also being applied to other lithium-ion batteries being developed for the International Space Station, Extravehicular Mobility Unit and other programs. Modeling guidance and future efforts are discussed.
Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy (2018)

This work was funded or supported by grants from the AVM Butterfly Charity, the Wellcome Trust (UK), the Medical Research Council (UK), the UK National Institute for Health Research, the L'Oreal-Melanoma Research Alliance, the European Research Council, and the National Human Genome Research Institute (US).
CHARACTERISTICS AND DYNAMIC EVOLUTION OF INVERTED STRUCTURE IN YINGGEHAI BASIN (2012)

The Yinggehai basin is located in the juncture area between Indo-China continental block and northern continental margin of the South China Sea.The dynamical mechanism for generation and evolution of the Yinggehai basin has become a debating focus due to its complicated tectonic setting.Regional tectonic evolution which affects the development of the Yinggehai basin is systematically analyzed by integration of new regional data.It is believed that the escape structures formed by the collision of India plate and Eurasia plate,the clockwise rotation of Indo-China block and the deformation mechanism of the Red River Fault Zone in Cenozoic period controlled the generation and evolution of the Yinggehai basin directly or indirectly.There are three tectonic evolution phases in the Yinggehai basin.They are sinistral strike-slip extension phase,crust ductile extension and thermal subsidence phase,and accelerated subsidence phase.
Induced Codeposition: II. A Mathematical Model Describing the Electrodeposition of Ni‐Mo Alloys (1996)

A steady‐state mathematical model was developed to predict the behavior of the induced codeposition of Ni‐Mo alloys in the kinetic and mass‐transport controlled regions on rotating cylinder electrodes. The kinetic regions were characterized by a simple Tafel expression. A Nernst boundary layer representation described the mass transfer of ions through a diffusion layer. The governing features of the induced codeposition mechanism included soluble nickel acting as a catalyst to the molybdenum deposition and the generation of an absorbed intermediate species on the electrode surface. The resulting alloy composition was simulated for two electrolytes over a wide range of current densities and electrode rotation rates. The model predictions agreed with the observed trends in the experimental data.
Isolation of Lignans and Sesquiterpenoids from Leaves of<i>Zanthoxylum Naranjillo</i> (1996)

Abstract From the hexane crude extract of the leaves of Zanthoxylum naranjillo, fourteen compounds were isolated. Three sesquiterpenes: β-selinene, α-cyperone and (-)-juniper camphor; four furofuran lignans: (+)-sesamin, (-)-pluviatylol-4′-O-γ,γ-dimethylallyl ether, (-)-xanthoxylol-4′-O-γ,γ-dimethylallyl ether, (+)-piperitol-4′-O-γ,γ-dimethylallyl ether; four dibenzylbutyrolactone lignans: (-)-hinokinin, (-)-hibalactone, (-)-methylpluviatolide, (-)-kaerophylin; two furan lignans: (-)-cubebin and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin. Sitosterol was also present. These compounds were isolated for the first time from Z. naranjillo.