gebhart/patrepeval huggingface dataset:
Ultrasonic tagging of photon paths in scattering media:?parallel speckle modulation processing (1999)

Tagging of photon trajectories in scattering media is possible by application of a localized ultrasonic field to the sample and by measurement of the induced speckle modulation. Instead of using a single optical detector, which integrates the signal of many speckle grains, we propose a more efficient detection scheme that uses a CCD camera and parallel lock-in detection to record the full modulation of the speckle. The advantage of this multiplex detection is demonstrated, as well as the imaging capabilities of the process for biological tissues.
137. The synthesis of α-picolylisoquinolines as possible antimalarials. Part I (1936)

G. R. Clemo, H. McIlwain and W. McG. Morgan, J. Chem. Soc., 1936, 610 DOI: 10.1039/JR9360000610
Composite TiSi<sub>2</sub>/n + poly-Si low-resistivity gate electrode and interconnect for VLSI device technology (1982)

A composite polycide structure consisting of refractory metal silicide film on top of polysilicon has been considered as a replacement for polysilicon as a gate electrode and interconnect line in MOSFET integrated circuits. This paper presents fine-line patterning techniques and device characteristics of MOSFET's with a TiSi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> polycide gate. A coevaporated TiSi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> polycide gate was chosen for this study because it had 2 to 5 times lower resistivity as compared to other silicides. Polycide formation by electron-beam coevaporation is chosen in preference to sputtered TiSi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> because of lower oxygen contamination. The coevaporation technique to form TiSi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> polycide with a sheet resistivity of 1 Ω/square (bulk resistivity of 21 µΩ.cm) is described. Anisotropic etching of nominally 1-µm lines with a 15:1 etch selectivity against oxide is reported. Measurements of metal-semiconductor work function, fixed oxide charge density, dielectric strength, oxide defect density, mobile-ion contamination, threshold voltage, and mobility have been made on polycide structures with 25-nm gate oxides. These MOS parameters correspond very closely to those obtained for n+ poly-Si gates. In addition, the specific contact resistivity between Al and TiSi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> polycide is lower than the contact resistivity between Al and polysilicon by one order of magnitude.
A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism (1999)

Sixty-six hirsute women were randomized and treated with 1) flutamide (n = 15), 250 mg/day; 2) finasteride (n = 15), 5 mg/day; 3) ketoconazole (n = 16), 300 mg/day; and 4) ethinyl estradiol (EE)-cyproterone acetate (CPA; n = 20), 0.01 mg EE/day for the first week, 0.02 mg EE/day for the second week, and 0.01 mg EE/day for the third week, followed by a pause of 7 days, then 12.5 mg CPA/day added during the first 10 days of every month for 12 months. Hirsutism was evaluated by the Ferriman-Gallwey score, and hair diameter and hair growth rate were determined by a special image analysis processor in basal conditions and after 90, 180, 270, and 360 days of treatment. All treatments produced a significant decrease in the hirsutism score, hair diameter, and daily hair growth rate: flutamide, -55 +/- 13%, -21 +/- 14%, and -37 +/- 18%; finasteride, -44 +/- 13%, -16 +/- 12%, and -27 +/- 14%; ketoconazole, -53 +/- 18%, -14 +/- 12%, and -30 +/- 21%; and EE-CPA, -60 +/- 18%, -20 +/- 11%, and -28 +/- 21%. Some differences existed among treatments with regard to effectiveness; EE-CPA and flutamide seem to be the most efficacious in improving hirsutism. For the hirsutism score, a greater decrease was seen with EE-CPA (-60 +/- 18%) than with finasteride (-44 +/- 13%; P < 0.01) and a greater decrease was seen with flutamide (-58 +/- 18%) than with finasteride (-44 +/- 13%; P < 0.05). Flutamide is the fastest in decreasing hair diameter; EE-CPA is the fastest in slowing down hair growth, even though at the end of the treatment there was a significant difference between flutamide and finasteride only (-41 +/- 18% vs. -27 +/- 14%; P < 0.05). Flutamide, ketoconazole, and EE-CPA induced a significant decrease in total and free testosterone, 5alpha-dihydrotestosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione plasma levels. During the EE-CPA treatment, gonadotropins were suppressed, and the sex hormone-binding globulin level increased. Finasteride induced a decrease in dehydroepiandrosterone sulfate and 5alpha-dihydrotestosterone and an increase in testosterone levels. Very few side-effects were observed during treatment with low doses of flutamide, EE-CPA, and particularly finasteride. Flutamide induced a decrease whereas EE-CPA induced an increase in triglycerides and cholesterol, showing higher values within the normal range. Ketoconazole induced several side-effects and complications, and several people dropped out of the study. Despite different modalities of action and significantly different effects on androgen levels, low doses of flutamide, finasteride, and EE-CPA constitute very satisfactory alternative therapeutic regimens in the treatment of hirsutism.
Implementation of detection and tracking mechanism for small UAS (2016)

Unmanned Aircraft Systems (UAS) are being used commonly for video surveillance, providing valuable video data and reducing the risks associated with human operators. Thanks to its benefits, the UAS traffic is nearly doubling every year. However, the risks associated with the UAS are also growing. According to the FAA, the volume of air traffic will grow steadily, doubling in the next 20 years. Paired with the exponential growth of the UAS traffic, the risk of collision is also growing as well as privacy concerns. An effective UAS detection and/or tracking method is critically needed for air traffic safety. This research is aimed at developing a system that can identify/detect a UAS, which will subsequently enable counter measures against UAS. The proposed system will identify a UAS through various methods including image processing and mechanical tracking. Once a UAS is detected, a countermeasure can be employed along with the tracking system. In this research, we describe the design, algorithms, and implementation details of the system as well as some performance aspects. The proposed system will help keep the malicious or harmful UAS away from the restricted or residential areas.
Interpretation of ultrasonic echo amplitude (1961)

An equation is deduced for the amplitude S of the signal received by a transducer, radius a, from a circular discontinuity, radius T, which is plane and parallel to the transducer face at a distance R, where k = 2?/? and x = kat/R, S0 being an arbitrary reference amplitude. Experiments verifying the equation are described, and the results quoted. The equation is shown to be more generally applicable than one recently put forward by Krautkr?mer. It is shown that the equation obviates the use of the many test-blocks at present used in ultrasonic inspection.
High-speed switch scheduling for local-area networks (1993)

Current technology trends make it possible to build communication networks that can support high-performance distributed computing. This paper describes issues in the design of a prototype switch for an arbitrary topology point-to-point network with link speeds of up to 1 Gbit/s. The switch deals in fixed-length ATM-style cells, which it can process at a rate of 37 million cells per second. It provides high bandwidth and low latency for datagram traffic. In addition, it supports real-time traffic by providing bandwidth reservations with guaranteed latency bounds. The key to the switch's operation is a technique called parallel iterative matching , which can quickly identify a set of conflict-free cells for transmission in a time slot. Bandwidth reservations are accommodated in the switch by building a fixed schedule for transporting cells from reserved flows across the switch; parallel iterative matching can fill unused slots with datagram traffic. Finally, we note that parallel iterative matching may not allocate bandwidth fairly among flows of datagram traffic. We describe a technique called statistical matching , which can be used to ensure fairness at the switch and to support applications with rapidly changing needs for guaranteed bandwidth.
Pharmacology of Leukotriene Receptor Antagonists and 5‐Lipoxygenase Inhibitors in the Management of Asthma (1997)

The leukotrienes (LTs), a family of inflammatory mediators arising from the metabolism of arachidonic acid via the 5-lipoxygenase pathway, are prominently implicated in the pathobiology of asthma. Two classes of LTs, the cysteinyl LTs (LTC4, LTD4, and LTE4) and the dihydroxy-LT (LTB4) have been identified, with each class acting via distinct receptors. Inhibition of LT-mediated inflammation can be achieved by either interruption of 5-lipoxygenase action, thereby preventing formation of the LTs, or inhibition at specific LT receptor sites in the airway. Both the 5-lipoxygenase inhibitors and the cysLT receptor antagonists have thus far demonstrated the capacity to improve pulmonary function and reduce symptoms in clinical models of asthma, such as exercise-, aspirin-, or antigen-induced bronchoconstriction, and to improve pulmonary function in patients with mild-to-moderate, chronic stable asthma. The LTs are therefore critical effector molecules in some patients with asthma and important targets in the pharmacologic management of this disease.
Enhanced and Reversible Contact Angle Modulation of Ionic Liquids in Oil and under AC Electric Field (2010)

Ambience matters: Electrowetting behavior of ionic liquids in oil and under AC electric field shows greatly enhanced and reversible contact angle modulation as compared to that in air or under DC electric field (see picture). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Both <scp>CRISPR</scp>/<scp>C</scp>as‐based nucleases and nickases can be used efficiently for genome engineering in <i><scp>A</scp>rabidopsis thaliana</i> (2014)

Engineered nucleases can be used to induce site-specific double-strand breaks (DSBs) in plant genomes. Thus, homologous recombination (HR) can be enhanced and targeted mutagenesis can be achieved by error-prone non-homologous end-joining (NHEJ). Recently, the bacterial CRISPR/Cas9 system was used for DSB induction in plants to promote HR and NHEJ. Cas9 can also be engineered to work as a nickase inducing single-strand breaks (SSBs). Here we show that only the nuclease but not the nickase is an efficient tool for NHEJ-mediated mutagenesis in plants. We demonstrate the stable inheritance of nuclease-induced targeted mutagenesis events in the ADH1 and TT4 genes of Arabidopsis thaliana at frequencies from 2.5 up to 70.0%. Deep sequencing analysis revealed NHEJ-mediated DSB repair in about a third of all reads in T1 plants. In contrast, applying the nickase resulted in the reduction of mutation frequency by at least 740-fold. Nevertheless, the nickase is able to induce HR at similar efficiencies as the nuclease or the homing endonuclease I-SceI. Two different types of somatic HR mechanisms, recombination between tandemly arranged direct repeats as well as gene conversion using the information on an inverted repeat could be enhanced by the nickase to a similar extent as by DSB-inducing enzymes. Thus, the Cas9 nickase has the potential to become an important tool for genome engineering in plants. It should not only be applicable for HR-mediated gene targeting systems but also by the combined action of two nickases as DSB-inducing agents excluding off-target effects in homologous genomic regions.
Kinetics of Formation of Ca<sup>2+</sup> Complexes of Acyclic and Macrocyclic Poly(amino carboxylate) Ligands:  Bimolecular Rate Constants for the Fully-Deprotonated Ligands Reveal the Effect of Macrocyclic Ligand Constraints on the Rate-Determining Conversions of Rapidly-Formed Intermediates to the Final Complexes (1997)

The apparent bimolecular rate constants, k(1) (M(-)(1) s(-)(1)), for the formation of Ca(2+) complexes of a series of acyclic (edta, egta, cdta) and macrocyclic (dota, teta, do3a) poly(amino carboxylate) ligands were determined in the pH range 7-13 using the fluorescent ligand quin2 in a stopped-flow apparatus to monitor the ligand competition reaction. The k(1) values are observed to reach maximum constant values at high pH, characteristic of reactions involving the fully-deprotonated ligand species. Bimolecular formation constants k(Ca)(L), k(Ca)(HL), and k(Ca)(H)()2(L), characteristic of the reaction of the fully-deprotonated and mono- and diprotonated ligands, respectively, were derived from the pH dependence of the k(1) values. The k(Ca)(L) values of the acyclic ligands are edta, 4.1 x 10(9) M(-)(1) s(-)(1); egta, 2.1 x 10(9) M(-)(1) s(-)(1); and cdta, 2.3 x 10(9) M(-)(1) s(-)(1), while the corresponding values for the macrocyclic ligands are dota, 4.7 x 10(7) M(-)(1) s(-)(1); teta, 1.1 x 10(7) M(-)(1) s(-)(1); and do3a, 1.0 x 10(8) M(-)(1) s(-)(1). The smaller values for the macrocyclic ligands are consistent with ligand-dictated constraints imposed on the conversion of a stable intermediate to the final complex, a process which involves the simultaneous stripping of several water molecules from the first-coordination sphere of the Ca(2+) ion.
Large-Scale Image Retrieval with Attentive Deep Local Features (2017)

We propose an attentive local feature descriptor suitable for large-scale image retrieval, referred to as DELE (DEep Local Feature). The new feature is based on convolutional neural networks, which are trained only with image-level annotations on a landmark image dataset. To identify semantically useful local features for image retrieval, we also propose an attention mechanism for key point selection, which shares most network layers with the descriptor. This frame-work can be used for image retrieval as a drop-in replacement for other keypoint detectors and descriptors, enabling more accurate feature matching and geometric verification. Our system produces reliable confidence scores to reject false positives–in particular, it is robust against queries that have no correct match in the database. To evaluate the proposed descriptor, we introduce a new large-scale dataset, referred to as Google-Landmarks dataset, which involves challenges in both database and query such as background clutter, partial occlusion, multiple landmarks, objects in variable scales, etc. We show that DELE outperforms the state-of-the-art global and local descriptors in the large-scale setting by significant margins.
Paired‐pulse depression of monosynaptic GABA‐mediated inhibitory postsynaptic responses in rat hippocampus. (1990)

1. Intracellular recording techniques were used to characterize monosynaptic inhibitory postsynaptic potentials (IPSPs) and currents (IPSCs) in rat hippocampal slices and to study the mechanism of paired-pulse depression of these synaptic responses. This was achieved by stimulation in stratum radiatum close (less than 0.5 mm) to an intracellularly recorded CA1 neurone after pharmacological blockade of all excitatory synaptic transmission. 2. Under these conditions, low-frequency stimulation (0.033 Hz) evoked a pure biphasic IPSP, which had a short and constant latency to onset. This IPSP was blocked by tetrodotoxin (1 microM) suggesting that it resulted from the electrical stimulation of the axons and/or cell bodies of a monosynaptic inhibitory pathway. 3. Picrotoxin (100 microM) abolished the early component of the biphasic IPSP/C. It left an intact, pure late IPSP/C (IPSP/CB) which had a latency to onset of 29 +/- 2 ms, latency to peak of 139 +/- 4 ms, a duration of 723 +/- 135 (range 390-1730) ms and a reversal potential of -93 +/- 2 mV. The duration was highly dependent on the stimulus intensity whereas the latency to onset was largely independent of the stimulus intensity. The IPSP/CB was reduced or abolished by 1 mM-phaclofen. 4. Phaclofen (1 mM) and 2-hydroxy-saclofen (0.1-1.0 mM) reversibly depressed (60-100%) the late component of the biphasic IPSP/C and, where maximally effective, left a pure, early IPSP/C (IPSP/CA). The IPSP/CA had a latency to onset of 3 ms or less, a latency to peak of 17 +/- 1 ms, a duration of 225 +/- 3 ms and a reversal potential of -75 +/- 2 mV. 5. Two shocks of identical strength were applied in close succession to characterize, and to study the mechanisms underlying, frequency-dependent depression of inhibitory synaptic responses. Paired-pulse depression was seen for both phases of the biphasic IPSP/C and of the pure IPSP/CB, recorded in the presence of picrotoxin. Paired-pulse depression was not accompanied by changes in the reversal potential of either component, indicating that it was caused by a reduction in the two synaptic conductances. Paired-pulse depression was greater when high stimulus intensities were employed. 6. Paired stimuli were applied at separation intervals of between 5 ms and 10 s to determine the temporal profile of frequency-dependent depression. Paired-pulse depression of both IPSCA and IPSCB was most pronounced at an interstimulus interval of 100-125 ms and ceased to occur at intervals greater than 5 10s.(ABSTRACT TRUNCATED AT 400 WORDS)
Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340) (2015)

Dysregulation of pre-mRNA splicing machinery activity has been related to the biogenesis of several diseases. The serine/arginine-rich protein kinase family (SRPKs) plays a critical role in regulating pre-mRNA splicing events through the extensive phosphorylation of splicing factors from the family of serine/arginine-rich proteins (SR proteins). Previous investigations have described the overexpression of SRPK1 and SRPK2 in leukemia and other cancer types, suggesting that they would be useful targets for developing novel antitumor strategies. Herein, we evaluated the effect of selective pharmacological SRPK inhibition by N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide (SRPIN340) on the viability of lymphoid and myeloid leukemia cell lines. Along with significant cytotoxic activity, the effect of treatments in regulating the phosphorylation of the SR protein family and in altering the expression of MAP2K1, MAP2K2, VEGF and FAS genes were also assessed. Furthermore, we found that pharmacological inhibition of SRPKs can trigger early and late events of apoptosis. Finally, intrinsic tryptophan fluorescence emission, molecular docking and molecular dynamics were analyzed to gain structural information on the SRPK/SRPIN340 complex. These data suggest that SRPK pharmacological inhibition should be considered as an alternative therapeutic strategy for fighting leukemias. Moreover, the obtained SRPK-ligand interaction data provide useful structural information to guide further medicinal chemistry efforts towards the development of novel drug candidates.
Execution of data mappers (2004)

Data mappers are essential operators for implementing data transformations supporting schema mapping and integration scenarios such as legacy data migration, ETL processes for data warehousing, data cleaning activities, and business integration initiatives. Despite their widespread use, no formalization of this important operation has been proposed so far. In this paper we propose the data mapper operator as an extension to the relational algebra. We supply a set of algebraic rewriting rules for optimizing queries that combine standard relational operators with data mappers. Finally, we propose algorithms for their efficient physical execution.
A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis (2010)

Lymphocyte perforin and serine protease granzymes are well-recognized extrinsic mediators of apoptosis. We now demonstrate that cytotoxic lymphocyte granule components profoundly augment the myeloid cell inflammatory cytokine cascade in response to TLR4 ligation. Whereas caspase-1-deficient mice were completely resistant to LPS, reduced serum cytokine production and resistance to lethal endotoxicosis were also obtained with perforin-deficient mice, indicating a role for granzymes. Consistently, a lack of granzyme M (GrzM) resulted in reduced serum IL-1alpha, IL-1beta, TNF, and IFN-gamma levels and significantly reduced susceptibility to lethal endotoxicosis. These altered responses were also observed in granzyme A-deficient but not granzyme B-deficient mice. A role for APC-NK cell cross-talk in the inflammatory cascade was highlighted, as GrzM was exclusively expressed by NK cells and resistance to LPS was also observed on a RAG-1/GrzM-double deficient background. Collectively, the data suggest that NK cell GrzM augments the inflammatory cascade downstream of LPS-TLR4 signaling, which ultimately results in lethal endotoxicosis. Most importantly, these data demonstrate that granzymes should no longer be considered solely as mediators of apoptosis, but additionally as potential key regulators of inflammation.
Cobalamin-Dependent Methyltransferases (2001)

Cobalamin cofactors play critical roles in radical-catalyzed rearrangements and in methyl transfers. This Account focuses on the role of methylcobalamin and its structural homologues, the methylcorrinoids, as intermediaries in methyl transfer reactions, and particularly on the reaction catalyzed by cobalamin-dependent methionine synthase. In these methyl transfer reactions, the cobalt(I) form of the cofactor serves as the methyl acceptor. Biological methyl donors to cobalamin include N5-methyltetrahydrofolate, other methylamines, methanol, aromatic methyl ethers, acetate, and dimethyl sulfide. The challenge for chemists is to determine the enzymatic mechanisms for activation of these unreactive methyl donors and to mimic these amazing biological reactions.