gebhart/patrepeval huggingface dataset:
Methodology to assess fracture during crash simulation: fracture strain criteria and their calibration (2017)

The use of Advanced High Strength Steels (AHSS) has greatly increased this last decade in the automotive industry. Because of their crash performance and their weight saving potential, these grades constitute a possible solution to achieve the safety and environmental regulations objectives. Nevertheless, the increase of tensile strength of these materials is generally associated with a loss of ductility compared to conventional steels. Thus, the prediction of their failure in crash loading conditions become of great importance for the design of vehicles. This paper proposes to calibrate for any AHSS, as Dual-Phase or Press Hardened Steels, different failure criteria, available in finite element software. First, specific tests and methodologies for strain measurement needed for models calibration are exposed. Second, an overview of these tested models and the procedure applied to take into account mesh dependency are provided. Finally, simulations results are compared with experiment on a real automotive component.
Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers (2013)

Recent clinical trials of small interfering RNAs (siRNAs) highlight the need for robust delivery technologies that will facilitate the successful application of these therapeutics to humans. Arguably, cell targeting by conjugation to cell-specific ligands provides a viable solution to this problem. Synthetic RNA ligands (aptamers) represent an emerging class of pharmaceuticals with great potential for targeted therapeutic applications. For targeted delivery of siRNAs with aptamers, the aptamer-siRNA conjugate must be taken up by cells and reach the cytoplasm. To this end, we have developed cell-based selection approaches to isolate aptamers that internalize upon binding to their cognate receptor on the cell surface. Here we describe methods to monitor for cellular uptake of aptamers. These include: (1) antibody amplification microscopy, (2) microplate-based fluorescence assay, (3) a quantitative and ultrasensitive internalization method (<i>"QUSIM"</i>) and (4) a way to monitor for cytoplasmic delivery using the ribosome inactivating protein-based (RNA-RIP) assay. Collectively, these methods provide a toolset that can expedite the development of aptamer ligands to target and deliver therapeutic siRNAs <i>in vivo</i>.
Single link switching mechanism for fast recovery in tree-based recovery schemes (2008)

In this paper, we propose a Self-protected Spanning Tree (SST) construction algorithm and the corresponding single link switching mechanism (SLSM) for tree-based recovery schemes. Using SLSM, an SST can recover from any single link failure without the help of the other trees. When some link fails, SLSM transforms an SST into another spanning tree by only replacing the failed link in the tree with another normal link out of the tree. SLSM-based recovery mechanism is evaluated using the prevalent Ethernet technology, whose resilience issue is attracting much attention. Simulation results demonstrate the effectiveness of SLSM in achieving fast recovery. Another feature of SLSM is that it provides a novel load balance mechanism by fast changing the topology of SST, which can not be implemented in the previously advocated tree-based schemes.
Abnormal clot retraction, altered fibrin structure, and normal platelet function in multiple myeloma (1994)

Clot retraction, measured by serum expression, is absent in some cases of multiple myeloma. Decreased clot retraction has been attributed to platelet dysfunction. A new instrument allows simultaneous measurement of platelet-mediated force development during clot retraction and of clot elastic modulus. We report 10 patients with immunoglobulin (Ig) G myeloma in whom the abnormalities of fibrin structure were quantitatively defined and platelet-fibrin interactions were assessed. Fiber mass-to-length ratios were calculated from gel turbidity. Platelet force development and clot elastic modula were measured in platelet-rich plasma gels. Fiber mass-to-length ratios for IgG myeloma patients were smaller (means +/- SE) (0.98 +/- 0.19 x 10(13) Da/cm) than for normal controls (1.36 +/- 0.06 x 10(13) Da/cm), indicating thinner fiber formation. Elastic modula of myeloma clots (51,013 +/- 14,660 dyn/cm2) were strikingly larger than modula for normal controls (23,355 +/- 1,887 dyn/cm2), indicating that such clots are mechanically less flexible. Platelet force development 1,200 s after thrombin addition was not diminished in myeloma patients (8,315 +/- 1,155 dyn) vs. controls (6,906 +/- 606 dyn). Abnormal clot retraction in myeloma appears to be primarily due to altered clot structure rather than platelet dysfunction.
Assessing Blunt Cannulae as Replacements for Hypodermic Needles During Intravenous Therapy Safety and Utility (1997)

Metal 18-ga cannulae can be inserted through virtually all intact standard rubber vial membranes or standard Y-ports to allow safe IV access. A single prepuncture of any standard latex membrane allows economical blunt metal cannula access equally efficiently as with expensive pre-slit membranes and without loss of membrane integrity.
A Genome-Scale DNA Repair RNAi Screen Identifies SPG48 as a Novel Gene Associated with Hereditary Spastic Paraplegia (2010)

DNA repair is essential to maintain genome integrity, and genes with roles in DNA repair are frequently mutated in a variety of human diseases. Repair via homologous recombination typically restores the original DNA sequence without introducing mutations, and a number of genes that are required for homologous recombination DNA double-strand break repair (HR-DSBR) have been identified. However, a systematic analysis of this important DNA repair pathway in mammalian cells has not been reported. Here, we describe a genome-scale endoribonuclease-prepared short interfering RNA (esiRNA) screen for genes involved in DNA double strand break repair. We report 61 genes that influenced the frequency of HR-DSBR and characterize in detail one of the genes that decreased the frequency of HR-DSBR. We show that the gene KIAA0415 encodes a putative helicase that interacts with SPG11 and SPG15, two proteins mutated in hereditary spastic paraplegia (HSP). We identify mutations in HSP patients, discovering KIAA0415/SPG48 as a novel HSP-associated gene, and show that a KIAA0415/SPG48 mutant cell line is more sensitive to DNA damaging drugs. We present the first genome-scale survey of HR-DSBR in mammalian cells providing a dataset that should accelerate the discovery of novel genes with roles in DNA repair and associated medical conditions. The discovery that proteins forming a novel protein complex are required for efficient HR-DSBR and are mutated in patients suffering from HSP suggests a link between HSP and DNA repair.
An Innovative Method for the Alignment of Astronomical Telescopes (2001)

An algorithm is presented that accomplishes the optical alignment of Cassegrain and Ritchey‐Chrétien astronomical telescopes. The algorithm does an iterative comparison and minimization of the error between the ideal pattern of the transverse aberration, TA, and the actual or measured pattern of the TA of the telescope. The TA is obtained with a Hartmann mask placed on the base plate of the telescope and is detected by a CCD camera near the focal plane.
Real-time implementation of multi-band frequency compression for listeners with moderate sensorineural impairment (2012)

Widening of auditory filters in persons with sensorineural hearing impairment leads to increased spectral masking and degraded speech perception. Multi-band frequency compression of the complex spectral samples using pitchsynchronous processing has been reported to increase speech perception by persons with moderate sensorineural loss. It is shown that implementation of multi-band frequency compression using fixed-frame processing along with leastsquares error based signal estimation reduces the processing delay and the speech output is perceptually similar to that from pitch-synchronous processing. The processing is implemented on a DSP board based on the 16-bit fixed-point processor TMS320C5515, and real-time operation is achieved using about one-tenth of its computing capacity. Index Terms: sensorineural hearing loss, multi-band frequency compression, real-time processing
A seamlessly integrated microfluidic pressure sensor based on an ionic liquid electrofluidic circuit (2011)

A novel pressure sensor with electrical readout based on ionic liquid (IL) electrofluidic circuit is reported in this paper. The pressure measurement is achieved by measuring the electrical property variation of the circuit induced by the pressure inside the microfluidic devices. The sensor integrated microfluidic device is made of polydimethylsiloxane (PDMS), and can be fabricated using the well-developed multilayer soft lithography (MSL) without additional microfabrication processes. Therefore, the pressure sensor is fully disposable, and can be seamlessly integrated into PDMS microfluidic devices. Moreover, an IL electrofluidic Wheatstone bridge is designed to provide the device linear output, great long-term and thermal stability. In this paper, the sensor performance characterization using pressurized gas and liquid flowing in the microfluidic channel have been conducted. The experimental results demonstrate the advantages of the device. The developed pressure sensor has great potentials for the development of next generation sensor-integrated microfluidic systems.
A new hybrid power technique utilizing a direct Copper to ceramic bond (1976)

A new technique of bonding copper directly to ceramic, employing the copper-copper oxide eutectic melt, is described. Scanning electron micrographs (SEM) and EDAX are used to study the details of this bond. A specific utilization of these techniques is portrayed in a 2-SCR-3-diode controlled bridge. This bridge is used as a 2-hp dc motor speed control. The advantages of using these techniques over previous methods (thick film or moly-manganese) lie in the ability to bond almost any thickness of high-conductivity copper to ceramics (Al <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> , BeO, BN, ZnO, etc.) silica, dissimilar metals, or to copper itself. Incidental benefits, described in the report, include bonding copper lead frames instead of screen printing, lack of high thermal and electrical resistivity interface layers, and simplicity of manufacture. Ceramic properties found to influence bond quality were: 1) Topology in terms of a fractured surface due to lapping and/or die sticking. 2) Degree of intergranular bond strength. 3) Cleanliness of surface and degree of unbonded particulate matter (powder) on the surface. 4) Grain size. The bonding agent is characterized as a field of bonded Cu <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O nodules precipitated from the Cu-Cu <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O eutectic melt with a density much higher than expected from the 4.7-percent Cu <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O (by volume) contained in the eutectic mixture. Mechanisms to explain this behavior are described. The bond strength is noted to depend on the nodule density and the bond strength of the Cu <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O to copper and is higher than any other bonding method.
Bimodal character of polyester–solvent interactions. I. Evaluation of the solubility parameters of the aromatic and the aliphatic ester residues of poly(ethylene terephthalate) (1977)

Abstract The Hildebrand and the Hansen solubility parameters of the aromatic and the aliphatic ester residues of poly(ethylene terephthalate), PET, are evaluated and compared to those determined experimentally. The interactions of nonaqueous solvents with the aromatic and aliphatic ester residues of PET are also described in terms of their relative basicity and acidity in the Lewis sense, where the aromatic residue may be taken as a Lewis acid and the aliphatic ester residue may be taken as a Lewis base.
Early detection of human gastric cancer based on morphologic and enzymologic studies. (1982)

Atypical glandular proliferations of gastric mucosa and carcinomas were studied with histologic, cytophotometric, and enzymologic methods in 35 resected human stomachs. By the use of Feulgenis cytophotometry and a new mathematical test developed by us, aneuploid DNA content could be demonstrated in some grade II and grade III dysplasias as well as carcinomas. Alkaline phosphatase isoenzymes were detected with polyacrylamide disk gelelectrophoresis. Liver-type isoenzymes were detectable, though with varying rates, in both intact gastric mucosa and in lesions studied. The intestinal-type isoenzyme, however, did not occur in intact gastric mucosa or in inflammatory epithelial changes, in contrast to all cases of intestinal metaplasia and some of the gastric dysplasias and carcinomas, where it was present. Placental-type ALP isoenzyme (Regan enzyme) was observed only in grade II and grade III dysplasias and carcinomas. Simultaneous occurrence of Regan isoenzyme and aneuploid DNA content could be observed in 70% of dysplasias and carcinomas. In view of our observations, one can suppose that the presence of these markers in dysplasia is suggestive of malignant transformation.
A 1/3" format image sensor with refractory metal light shield for color video applications (2003)

The authors report results obtained on a full-color interline transfer CCD (charged-coupled device) image sensor with pixel dimensions of 8.6 mu m(H)*6.8 mu m(V) using 1.2- mu m design rules and a two-phase, single-polysilicon-per-phase technology. In order to reduce image smear and to provide suitable topography for integral color filters, a refractory light shield with a flowed glass overlayer was incorporated. The basic sensor and pixel architecture is shown. Image smear as a percent of full well, measured with 10% vertical illumination at saturated intensity, is shown as a function of wavelength. Smear is lowest at short wavelengths but is at an acceptable level for applications with controlled illumination.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis and Metabolism of the First Thia-Bilirubin (2001)

A symmetrical C(10)-thiabilirubin analogue, 8,12-bis(2-carboxyethyl)-2,3,17,18-tetraethyl-7,13-dimethyl-10-thia-(21H,23H,24H)-bilin-1,19-dione (1), was synthesized from 8-(2-carboxyethyl)-2,3-diethyl-7-methyl-10H-dipyrrin-1-one in one step by reaction with sulfur dichloride. The thia-rubin exhibited the expected IR, UV-vis, and NMR spectroscopic properties, which are rather similar to those of mesobilirubin-XIIIalpha. Like bilirubin and mesobilirubin, 1 adopts an intramolecularly hydrogen-bonded conformation, shaped like a ridge-tile but with a steeper pitch. The longer C-S bond lengths and smaller bond angles at C-S-C, as compared to C-CH(2)-C, lead to an interplanar angle between the two dipyrrinones of only 74 degrees -or considerably less than that of bilirubin (approximately 100 degrees). On normal- and reversed-phase chromatography, 1 is substantially less polar than bilirubin. Despite this conformational distortion, 1 is metabolized in normal rats to acyl glucuronides, which are secreted into bile. In mutant (Gunn) rats lacking bilirubin glucuronosyl transferase, 1 (like bilirubin) was not excreted in bile.
Monoclonal antibodies as probes of the structure and function of insulin receptors (1987)

Conference Article| February 01 1987 Monoclonal antibodies as probes of the structure and function of insulin receptors KENNETH SIDDLE; KENNETH SIDDLE *Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, U.K. Search for other works by this author on: This Site PubMed Google Scholar MARIA A. SOOS; MARIA A. SOOS *Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, U.K. Search for other works by this author on: This Site PubMed Google Scholar RICHARD M. O'BRIEN; RICHARD M. O'BRIEN *Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROSALIND H. GANDERTON; ROSALIND H. GANDERTON *Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROY TAYLOR ROY TAYLOR †Department of Medicine, University of Newcastle Medical School, Newcastle upon Tyne NE2 4HH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1987) 15 (1): 47–51. https://doi.org/10.1042/bst0150047 Article history Received: August 06 1986 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation KENNETH SIDDLE, MARIA A. SOOS, RICHARD M. O'BRIEN, ROSALIND H. GANDERTON, ROY TAYLOR; Monoclonal antibodies as probes of the structure and function of insulin receptors. Biochem Soc Trans 1 February 1987; 15 (1): 47–51. doi: https://doi.org/10.1042/bst0150047 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1987 Biochemical Society1987 Article PDF first page preview Close Modal You do not currently have access to this content.
How to Deal with Low-Resolution Target Structures: Using SAR, Ensemble Docking, Hydropathic Analysis, and 3D-QSAR to Definitively Map the αβ-Tubulin Colchicine Site (2013)

αβ-Tubulin colchicine site inhibitors (CSIs) from four scaffolds that we previously tested for antiproliferative activity were modeled to better understand their effect on microtubules. Docking models, constructed by exploiting the SAR of a pyrrole subset and HINT scoring, guided ensemble docking of all 59 compounds. This conformation set and two variants having progressively less structure knowledge were subjected to CoMFA, CoMFA+HINT, and CoMSIA 3D-QSAR analyses. The CoMFA+HINT model (docked alignment) showed the best statistics: leave-one-out q(2) of 0.616, r(2) of 0.949, and r(2)pred (internal test set) of 0.755. An external (tested in other laboratories) collection of 24 CSIs from eight scaffolds were evaluated with the 3D-QSAR models, which correctly ranked their activity trends in 7/8 scaffolds for CoMFA+HINT (8/8 for CoMFA). The combination of SAR, ensemble docking, hydropathic analysis, and 3D-QSAR provides an atomic-scale colchicine site model more consistent with a target structure resolution much higher than the ~3.6 Å available for αβ-tubulin.
Biometric Locker System (2011)

Storage locker system is for the temporarily keeping the goods. This study implements a storage locker system with the technique of fingerprint recognition as the way to open and close the lock. The system captures the fingerprint of the locker renter and requires a fingerprint match to reopen the locker door, ensuring that only the renter can open the locker door to remove its contents. This system not only reduces the trouble for customers to bring the key, but also increases the trust and security for customers. The implementation process and system recognition rate for the storage locker system are examined in this study.
The zebrafish klf gene family (2001)

The Krüppel-like factor (KLF) family of genes encodes transcriptional regulatory proteins that play roles in differentiation of a diverse set of cells in mammals. For instance, the founding member KLF1 (also known as EKLF) is required for normal globin production in mammals. Five new KLF genes have been isolated from the zebrafish, Danio rerio, and the structure of their products, their genetic map positions, and their expression during development of the zebrafish have been characterized. Three genes closely related to mammalian KLF2 and KLF4 were found, as was an ortholog of mammalian KLF12. A fifth gene, apparently missing from the genome of mammals and closely related to KLF1 and KLF2, was also identified. Analysis demonstrated the existence of novel conserved domains in the N-termini of these proteins. Developmental expression patterns suggest potential roles for these zebrafish genes in diverse processes, including hematopoiesis, blood vessel function, and fin and epidermal development. The studies imply a high degree of functional conservation of the zebrafish genes with their mammalian homologs. These findings further the understanding of the KLF genes in vertebrate development and indicate an ancient role in hematopoiesis for the Krüppel-like factor gene family.
Molecular beam epitaxy-grown PbSnTe-PbEuSeTe buried heterostructure diode lasers (1990)

Buried heterostructure (BH) PbSnTe-PbEuSeTe lasers with a PbSnTe active layer were fabricated for the first time using a two-stage molecular beam epitaxy (MBE) growth procedure. Lasers with 4- mu m-wide and 0.65- mu m-thick buried Pb/sub 0.961/Sn/sub Sn0.039/Te active layer and Pb/sub 0.985/Eu/sub 0.015/Se/sub 0.02/Te/sub 0.98/ cladding layers were grown. Continuous wave (CW) operating temperature of 175 K was measured with CW threshold currents of 1.6 mA (20 K), 13.6 mA (80 K), and 195 mA (160 K). Single-mode operation with 3.0-cm/sup -1/-mode tuning was measured at 1639.8 cm/sup -1/ emission.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Secure Ethernet Service (2005)

IEEE Committee 802.1 has initiated new work in the area of LAN / MAN security. These projects promise to yield LAN MAC layer security technology, which can be used as the basis for new Secure Ethernet Services. Such value added services will provider carriers with additional revenue opportunities. The goals of this paper are to summarize the relevant LAN security technology and associated standards status, define some potential network and service provider applications, and show how the requisite technology can be integrated into network elements.