gebhart/patrepeval huggingface dataset:
Transfection of human astrocytoma cells with glial fibrillary acidic protein complementary DNA: analysis of expression, proliferation, and tumorigenicity. (1993)

Glial fibrillary acidic protein (GFAP) is a M(r) 50,000 intracytoplasmic filamentous protein that constitutes a portion of, and is specific for the cytoskeleton of the astrocyte. GFAP appears to stabilize the astrocyte's cytoskeleton, and helps maintain normal astrocyte cell shape through complex interactions between it and the nuclear and plasma membranes. A critical observation from histopathological studies is that there is progressive loss of GFAP expression with increasing astrocytic anaplasia. To determine how GFAP expression affects human malignant astrocytoma cells that are GFAP-deficient, we have stably transfected GFAP-negative SF-126 human astrocytoma cells with a eukaryotic expression vector into which a complementary DNA for the entire coding sequence of the human GFAP protein has been inserted. Positive transformants were selected for neomycin resistance, and GFAP-positive astrocytoma cells have been identified by indirect immunofluorescence using anti-GFAP antibodies. Upon successful transfection, 5 stably transfected SF-126 astrocytoma cell clones were selected that produced GFAP, formed elongated processes in cell culture, and demonstrated decreased proliferation in a tritiated thymidine uptake assay when compared to the control. In addition, the 5 astrocytoma cell clones demonstrated marked reduction in the number and growth of colonies in soft agar when compared to the control. Southern analysis revealed extra copies of the GFAP complementary DNA that had become integrated into the SF-126 astrocytoma cell genome. Northern analysis revealed variable expression of a 3.5-kilobase GFAP mRNA transcript among the 5 cell clones. The amount of GFAP mRNA expression and immunoreactivity by the stably transfected SF-126 astrocytoma cell clones was found to correlate inversely with astrocytoma proliferation and growth in soft agar. The restoration of GFAP expression to GFAP-negative human astrocytoma cells has affected tumor cell morphology, proliferation, and growth in soft agar in this experimental cell system.
Cloning and expression of human corneal calgranulin C (CO-Ag) (1998)

CO-Ag is identical to calgranulin C, a neutrophil protein found on the surface of filarial nematodes. A host-parasite interaction may cause autoimmunity to CO-Ag (CaGC) in the cornea resulting in a Mooren's ulcer.
A Rapid and Economic In-House DNA Purification Method Using Glass Syringe Filters (2009)

This method provides DNA yield and quality similar to that obtained with commercial kits, but is more rapid and less costly.
Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors (2014)

Improved understanding of molecular drivers of carcinogenesis has led to significant progress in the management of lung cancer. Patients with non-small-cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK) gene rearrangements constitute about 4%-5% of all NSCLC patients. ALK+ NSCLC cells respond well to small molecule ALK inhibitors such as crizotinib; however, resistance invariably develops after several months of treatment. There are now several newer ALK inhibitors, with the next generation of agents targeting resistance mutations. In this review, we will discuss the prevalence and clinical characteristics of ALK+ lung cancer, current treatment options, and future directions in the management of this subset of NSCLC patients.
Explicit and Implicit Syntactic Features for Text Classification (2013)

Syntactic features are useful for many text classification tasks. Among these, tree kernels (Collins and Duffy, 2001) have been perhaps the most robust and effective syntactic tool, appealing for their empirical success, but also because they do not require an answer to the difficult question of which tree features to use for a given task. We compare tree kernels to different explicit sets of tree features on five diverse tasks, and find that explicit features often perform as well as tree kernels on accuracy and always in orders of magnitude less time, and with smaller models. Since explicit features are easy to generate and use (with publicly available tools), we suggest they should always be included as baseline comparisons in tree kernel method evaluations. 1
Gadara: dynamic deadlock avoidance for multithreaded programs (2008)

Deadlock is an increasingly pressing concern as the multicore revolution forces parallel programming upon the average programmer. Existing approaches to deadlock impose onerous burdens on developers, entail high runtime performance overheads, or offer no help for unmodified legacy code. Gadara automates dynamic deadlock avoidance for conventional multithreaded programs. It employs whole-program static analysis to model programs, and Discrete Control Theory to synthesize lightweight, decentralized, highly concurrent logic that controls them at runtime. Gadara is safe, and can be applied to legacy code with modest programmer effort. Gadara is efficient because it performs expensive deadlock-avoidance computations offline rather than online. We have implemented Gadara for C/Pthreads programs. In benchmark tests, Gadara successfully avoids injected deadlock faults, imposes negligible to modest performance overheads (at most 18%), and outperforms a software transactional memory system. Tests on a real application show that Gadara identifies and avoids both previously known and unknown deadlocks while adding performance overheads ranging from negligible to 10%.
An Efficient Strategy for Collision Resolution in Hash Tables (2014)

This paper presents NFO, a new and innovative technique for collision resolution based on single dimensional arrays. Hash collisions are practically unavoidable when hashing a random subset of a large set of possible keys and should be seen as an event that can disrupt the normal operations or flow of hash functions computing an index into an array of buckets or slots. Hash tables provide efficient table implementations but then its performance is greatly affected if there are high loads of collisions. This new approach intends to manage these collisions effectively and properly although there are some algorithms for handling collisions currently. NFO incorporates certain features to resolve some problems of existing techniques. The performance of our approach is quantified via analytical modeling and software simulations. Efficient implementations that are easily realizable and productive in modern technologies are discussed. The performance benefits are significant and require machines with moderate memory and speed specifications. Depending on observations of the results of implementation of the proposed approach or technique on a set of real data of several types, all results are registered and analyzed.
Fighting Phishing with Trusted Email (2010)

Phishing is the combination of social engineering and technical exploits designed to convince a victim to provide personal information, usually for the monetary gain of the attacker (phisher). Attempts to stop phishing by preventing a user from interacting with a malicious web site have shown to be ineffective. We introduce a method to aid in the prevention of phishing by combining automatic and transparent email signing with an email client plugin. The plugin can detect unsigned spoofed messages. In this manner, the user is prevented (or at least discouraged) from visiting malicious web sites, thus stopping the data-gathering phase of the phishing attack before it begins. We describe the system, implementation, weaknesses, and our ongoing user experiments.
Games Uniforms Unveiled (2008)

The uniforms for Beijing Olympics’ workers, technical staff and volunteers have been unveiled to mark the 200-day countdown to the Games. The uniforms feature the key element of the clouds of promise and will be in three colors:red for Beijing Olympic Games Committee staff, blue
39GHz GaN front end MMIC for 5G applications (2017)

This paper presents the design and the measured results of a GaN-based T/R MMIC suitable for millimeter-wave 5G applications. The design successfully integrated a PA, an LNA, and a T/R switch in one IC. At 39GHz, the transmit path achieved an average output power of 26dBm with 9% PAE and -30dBc ACPR under a 64QAM OFDM signal. The receive path achieved 16dB gain with 4dB NF. The fabricated MMIC is packaged in a low cost surface mount package in both single and dual channel versions to support multi-element phased array applications.
Electromagnetic analysis of diffraction gratings by the finite-difference time-domain method (1998)

Diffraction gratings with feature sizes comparable to the wavelength are analyzed with a finite-difference time-domain method, which is a unique approach to electromagnetic problems in the time domain. The diffraction efficiencies obtained are in good agreement with other commonly used numerical methods in the frequency domain. As a further application, diffraction problems with pulsed light are also investigated.
Searching biomedical databases on complementary medicine: the use of controlled vocabulary among authors, indexers and investigators (2003)

Searching biomedical databases for CAM is challenging due to inconsistent use of controlled vocabulary and indexing procedures in different databases. A standard terminology should be used by investigators in conducting their search strategies and authors when writing titles, abstracts and submitting keywords for publications.
Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94 (2013)

Peptide selectivity is a feature of inhibitory receptors for MHC class I expressed by natural killer (NK) cells. CD94-NKG2A operates in tandem with the polymorphic killer cell Ig-like receptors (KIR) and Ly49 systems to inhibit NK cells. However, the benefits of having two distinct inhibitory receptor-ligand systems are not clear. We show that noninhibitory peptides presented by HLA-E can augment the inhibition of NKG2A(+) NK cells mediated by MHC class I signal peptides through the engagement of CD94 without a signaling partner. Thus, CD94 is a peptide-selective NK cell receptor, and NK cells can be regulated by nonsignaling interactions. We also show that KIR(+) and NKG2A(+) NK cells respond with differing stoichiometries to MHC class I down-regulation. MHC-I-bound peptide functions as a molecular rheostat controlling NK cell function. Selected peptides which in isolation do not inhibit NK cells can have different effects on KIR and NKG2A receptors. Thus, these two inhibitory systems may complement each other by having distinct responses to bound peptide and surface levels of MHC class I.
Analysis of repeated unequally spaced channels for FDM lightwave systems (2000)

In long-haul optical frequency-division-multiplexing (FDM) systems, transmission characteristics are degraded by four-wave mixing (FWM). To overcome this problem, repeated unequally spaced (RUS) channels have been recently proposed as a new frequency allocation. In this paper, frequency distribution and intensity of generated FWM lights, and a total bandwidth of signal lights of RUS channels are compared with those of already known equally spaced (ES) and unequally spaced (US) channels. It is found that intensities of generated FWM lights of RUS are less than those of ES when the number of channels and a total bandwidth of signals are common in both channels. It is also revealed that RUS has a narrower total bandwidth than US when the number of channels and the minimum channel spacing are common in both channels. Since RUS simultaneously satisfies a low FWM light intensity and a narrow signal bandwidth, it is considered that RUS is suitable for FDM lightwave transmission systems.
Resource placement and assignment in distributed network topologies (2013)

We consider the problem of how to place and efficiently utilize resources in network environments. The setting consists of a regionally organized system which must satisfy regionally varying demands for various resources. The operator aims at placing resources in the regions as to minimize the cost of providing the demands. Examples of systems falling under this paradigm are 1) A peer supported Video on Demand service where the problem is how to place various video movies, and 2) A cloud-based system consisting of regional server-farms, where the problem is where to place various contents or end-user services. The main challenge posed by this paradigm is the need to deal with an arbitrary multi-dimensional (high-dimensionality) stochastic demand. We show that, despite this complexity, one can optimize the system operation while accounting for the full demand distribution. We provide algorithms for conducting this optimization and show that their complexity is pretty small, implying they can handle very large systems. The algorithms can be used for: 1) Exact system optimization, 2) deriving lower bounds for heuristic based analysis, and 3) Sensitivity analysis. The importance of the model is demonstrated by showing that an alternative analysis which is based on the demand means only, may, in certain cases, achieve performance that is drastically worse than the optimal one.
EOS AM-1 GaAs/Ge flexible blanket solar array (2002)

The Earth Observing System (EOS) AM-1 solar array will be the first operational flexible blanket array to use gallium arsenide on germanium (GaAs/Ge) solar cells. It will be one of the first arrays of any kind to use thin GaAs/Ge solar cells and to produce power at high voltage. The array thereby represents a significant advance in spacecraft array technology. This paper describes the progress made and the problems encountered since Kimber et al. (1993) reported on the tradeoffs that led to the array's configuration.
Logic representation of programs to detect arithmetic anomalies (2002)

Much interest, especially by banks and insurance companies is paid to detect arithmetic anomalies and inexactness of arithmetic expressions. Numerous examples in the past show that although mathematical methods for correct implementation of arithmetic expressions exist and are well understood, many programs contain arithmetic anomalies, impreciseness or faults. Software tests based on conventional coverage criteria (F. Belli, 1998) and functional tests are not well suited for detection of these faults. The detection of arithmetic anomalies by these methods strongly depends on the adequateness of test cases. The selection of effective test cases needs a lot of effort to detect context-sensitive arithmetic inexactness. The authors introduce a novel approach for detecting arithmetic anomalies. The method is based on the specification of fault classes combined with the transformation of the program under test into a predicate logic model. The number of potential context-sensitive faults is deployed as a criterion to precisely select modules in large software systems to increase the test effectiveness.
Years of life lost (YLL) from cancer is an important measure of population burden — and should be considered when allocating research funds (2005)

Recently, cancer mortality has been compared to research spending by the National Cancer Research Institute (NCRI), whose research budget is approximately pound sterling 250 million. The analysis shows a mis-match between mortality and research spending. As well as crude mortality rates, other measures of cancer burden should be considered because they contribute additional information. 'Years of life lost' (YLL) summed over each individual dying after a diagnosis of cancer represents a population-based mortality indicator of the impact of that disease on society. Years of life lost divided by the number of deaths for each cancer site produces an additional statistic, the average years of life lost (AYLL), which is a measure of the burden of cancer to the individual patient. For 17 cancer sites where data are available, four tumour sites have a rather large difference in mortality, comparing YLL to crude mortality. Years of life lost shows the population burden from cancers of the ovary, cervix, and CNS to be rather larger than suggested by crude mortality, despite screening programmes for cervix cancer. Using YLL, the underprovision of funding for lung cancer research is similar to that reported using percentage mortality. Breast cancer and leukaemia receive a relatively higher research spend than the population burden of these cancers, and the spending on leukaemia is quite extreme. Prostate cancer has a low per cent YLL but attracts a moderate amount of research spending. The use of AYLL as an indicator of individual cancer burden considerably changes the ranking of the mortality from different tumours. The mean AYLL is 12.5 years. Prostate cancer has the lowest AYLL, only 6.1 years; brain tumour patients have the highest, at just over 20 years. Comparing AYLL to research spending suggests four 'Cinderella' cancer sites with high individual cancer burden but low research spending: CNS tumours, cervix and kidney cancers, and melanoma. Breast cancer and leukaemia have roughly average AYLL but a considerable excess of research spending. YLL emphasises the discrepancy between research spending and mortality, and may be helpful for decisions concerning research support. Average years of life lost measures the burden to individual patients and may be helpful where individuals' needs are relevant, such as palliative care. As well as crude mortality, more subtle and comprehensive calculations of mortality statistics would be useful in debates on research funding and public health issues.
<i>In Vitro</i>Modeling of Human Bocavirus 1 Infection of Polarized Primary Human Airway Epithelia (2013)

Human bocavirus 1 (HBoV1) is an emerging human-pathogenic respiratory virus. We characterized two important features of HBoV1 infection in polarized primary human airway epithelia (HAE). Apical HBoV1 infection of HAE at a low multiplicity of infection causes disruption of the tight junction barrier, loss of cilia, and epithelial cell hypertrophy, which are hallmarks of the airway epithelial damage caused by HBoV1 infection. HBoV1 also infects HAE from the basolateral surface productively, although less efficiently, and this also leads to the characteristic airway epithelial damage.
Multiple-output resonant inverter topology for multi-inductor loads (2010)

Multiple-inductor systems are widely present in the current technology. These systems require controlling either the supplied voltage or power to several loads with different requirements simultaneously. As a consequence, the cost and size of the power stage may increase beyond the admissible limits for certain applications. Considering multiple-inductor loads, a novel multiple-output series resonant inverter (MOSRI) topology is proposed to obtain a cost-effective and high-power-density solution. The converter is based on a common inverter block and a resonant-load block. The performed analysis includes the description of the operation modes and the control strategy analysis. Domestic induction heating has been considered for application due to its special cost and size requirements, and the extensive inductor use. The proposed converter has been designed and validated experimentally through a prototype, which includes the power converter and the FPGA-based control architecture.
IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells (2015)

Indoleamine 2,3-dioxygenase-1 (IDO) is an immune regulatory enzyme expressed by most human tumors. IDO levels in tumor cells correlate with increased metastasis and poor patient outcome and IDO is linked to tumor cell resistance to immunotherapy, radiation therapy, and chemotherapy. Knowledge of tumor cell-autonomous effects of IDO, independent of its well-known role in regulating and suppressing anti-tumor immune responses, is limited. Clonal populations of A549 human lung adenocarcinoma cells stably transfected with anti-IDO shRNA or scrambled control shRNA were used to study IDO effects on drug sensitivity and resistance. IFNγ was used to induce IDO in those cells. We show, for the first time, that IDO mediates human tumor cell resistance to the candidate anticancer drugs FK866 (an NAD+ inhibitor), methoxyamine (MX, a base excision repair [BER] inhibitor) and approved anticancer drugs pemetrexed (a folate anti-metabolite) and gemcitabine (a nucleoside analogue), and combined treatment with pemetrexed and MX, in the absence of immune cells. Concurrent knockdown of IDO and thymidylate synthase (TS, a key rate-limiting enzyme in DNA synthesis and repair) sensitizes human lung cancer cells to pemetrexed and 5FUdR to a greater degree than knockdown of either target alone. We conclude that BER in IDO-expressing A549 cells plays a major role in mediating resistance to a range of approved and candidate anticancer drugs. IDO inhibitors are undergoing clinical trials primarily to improve antitumor immune responses. We show that targeting IDO alone or in combination with TS is a potentially valuable therapeutic strategy for cancer treatment, independent of immune activity and in combination with conventional chemotherapy.
Pulsed-to-Continuous Read Signal Converter for Increasing Read Signal-to-Noise Ratio (2008)

The signal-to-noise ratio (SNR) of the read signal from an optical disc was improved by using a new signal conversion technology. Using this technology, a pulsed read signal was converted into a continuous signal without signal amplitude loss, which was unavoidable using conventional method. The technology was tested on a spin-stand, and it was demonstrated that the SNR can be improved by decreasing the incident laser pulse duty and the feasibility of improving the bit error rate over two magnitudes.
[The role of malaria in febrile diseases in the urban environment of Ouagadougou (Burkina Faso, West Africa)]. (1991)

We studied from January to December 1988 the part played by malaria in the etiology of febrile diseases observed in three community clinics of Ouagadougou city (Burkina Faso, West Africa). The diagnosis of malaria attacks was based on the association of a body temperature equal or above 38 degrees C and a parasite density equal or above 10,000 parasitized red blood cells per mm3. We observed that fever attacks were primarily caused by malaria. Among the 5-14 years age group, malaria attacks were responsible for more than 50% of febrile cases and occurred mainly during the rainy season and at the beginning of the dry season (July to October). Ear, nose, throat and lung infections were the other dominant causes of fever attacks and were found during the whole year but especially during the dry season (February, March, September). They were followed by urinary and gastrointestinal infections and other tropical febrile diseases. Clinical diagnosis only of malaria attacks and even more so of fever attacks is poorly reliable.
Discriminant analysis of promoter regions in Escherichia coli sequences (1988)

We have previously developed a general method based on the statistical technique of discriminant analysis to predict splice junctions in eukaryotic mRNA sequences [Nakata, K., Kanehisa, M. and DeLisi, C. (1985) Nucleic Acids Res., 13, 5327-5340]. In order to evaluate further applicability of this method, we now analyze the promoter region of Escherichia coli sequences. The attributes used for discrimination include the accuracy of consensus sequence patterns measured by the perceptron algorithm, the thermal stability map, the base composition and the Calladine-Dickerson rules for helical twist angle, roll angle, torsion angle and propeller twist angle. When applied to selected E. coli sequences in the GenBank database, the method correctly identifies 75% of the true promoter regions.