gebhart/patrepeval huggingface dataset:
Activated Leukocyte Cell Adhesion Molecule (ALCAM) Expression is Associated with a Poor Prognosis for Bladder Cancer Patients (2003)

Objectives: Functional E-cadherin adhesion complexes are necessary to maintain the normal differentiated phenotype in bladder epithelial cells and dysfunction of molecules in this complex is associated with an invasive phenotype. Moreover, loss of functioning of E-cadherin and/or α-catenin in cancer cells is associated with a poor prognosis for bladder cancer patients. Clearly, other adhesion molecules are also involved in the process of invasion and/or metastasis. For example the expression of activated leukocyte cell adhesion molecule, ALCAM, an adhesion molecule belonging to the immunoglobulin superfamily, appeared to be correlated with malignant potential in human melanoma. Methods: The expression of ALCAM in human bladder cancer specimens was studied by immunohistochemistry and correlated with E-cadherin and α-catenin expression. Results: In normal bladder tissue, only the umbrella cells showed positive membrane staining of ALCAM. In 19 out of 52 bladder cancer specimens, we found ALCAM staining, particularly in those areas that showed aberrant expression of α-catenin and E-cadherin. Conclusions: There was a correlation between ALCAM expression in tumor cells and stage and grade, i.e. Ta-1:0/15, > T1: 19/37 (36.5%), G1: 0/5, G2: 2/14 (14.3%) and G3: 17/33 (51.5%) (Ta-1: > T1, G1:G2:G3, ). Moreover, positive ALCAM expression was strongly associated with a poor prognosis for bladder cancer patients. Multivariate analysis showed that ALCAM immunohistochemistry had additional prognostic value over pathological stage. Furthermore, it provides better prediction of prognosis when compared to grade and aberrant E-cadherin or α-catenin staining.
Electronic Conduction in Polymers. III. Electronic Properties of Polypyrrole (1963)

The electron spin resonance absorption and electrical resistivity have been measured under rigorous conditions for a series of polypyrroles prepared over the temperature range 120-500°. When plotted as a function of pyrolysis temperature the resistivity shows a maximum in the region 200-300°. Although the resistivity of the polymers prepared at 120° and 500° is roughly similar, their e.s.r. behaviour is quite different. The low-temperature polymer, containing much complexed iodine, shows a very broad signal arising from an excited state probably associated with a polypyrrole-iodine charge-transfer complex; the high temperature polymer, containing no iodine, shows a strong narrow signal arising from the ground state of the polymer. The changes in conductivity of the polymers following the adsorption of electron acceptor or donor molecules have been measured. It is concluded that, depending on the relative amounts of electron donating or attracting chemisorbed species in relation to the concentration of donor nitrogen atoms in the polypyrrole, the polymer may behave as an intrinsic or extrinsic semiconductor with n- or p-type characteristics. Charge-transfer complexes of strength sufficient to cause partial ionization induce extrinsic behaviour by changing the ratio of the number of electrons to the number of holes. Substituent groups such as the hetero atoms which interact with the p-electron system inductively or through resonance affect only the relative mobility of the charge carriers and induce intrinsic behaviour.
Human granulocyte generation of hydroxyl radical. (1978)

Human granulocytes were capable of oxidizing 2-keto-4 thiomethylbutyric acid to ethylene during phagocytosis or membrane perturbation. The reaction required hydrogen peroxide and superoxide and in addition was inhibited by various hydroxyl radical (OH) scavengers. These observations represent direct evidence for the generation of OH by human granulocytes. Further, inhibition of ethylene generation by azide and cyanide suggests that OH generation in granulocytes may be linked to myeloperoxidase.
Effect on the skin is violet color (2017)

This study compared two different research results (‘color has influence on the human body with energy wave’ vs. ‘visually stimulating color has an effect on the human body, creating a hormone response’) with the color violet. Based on the study results in which violet regenerates cells, a test was performed among 15 adult women in their 40-50s to determine the effects of moisture, pigment and wrinkles on skin. The subjects were divided into three groups (5 testees per group). In Group A, a massage was given using rose hip oil while both rose hip oil and violet colored oil were used for Group B. In Group C, the testees viewed the color with their naked eye for more than one minute before they were given a massage with rose hip oil and violet colored oil. The study results found the following: In terms of moisture, Group B showed the greatest effects. In pigments and wrinkles, on the contrary, Group C was most effective. Even though the same product was used, there was a difference between Groups B and C. These results show that the color energy wave has influence on the human body. In addition, it verifies that visually stimulating color energy has a greater effect on the human body. According to the said results, if color is properly used, it would be helpful in improving skin problems and easing diseases.
Effect of Synthetic Polylysine on Fungi (1960)

The synthetic, basic poly-alpha-amino acid, polylysine, had antifungal activity against plant pathogens (three strains of fusaria, three isolates of verticillia, and Ceratocystis fimbriata) and against the human pathogens (Trichophyton mentagrophytes, T. rubrum, and Candida albicans) in vitro. It inhibited penetration of Ceratocystis fimbriata on sweet potato slices. Polylysine inhibited the infection of tomato cuttings by Flsarium oxysporum f. lycopersici, but it was also toxic to the plants.
Bicultural responsiveness in Aotearoa New Zealand : an immigrant counsellor's perspective : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Education, Te Kupenga o te Mātauranga, Aotearoa New Zealand (2011)

This thesis examines my response, as an immigrant counsellor, counsellor educator, and member of a counsellors’ professional association, to the call by Māori for counsellors to honour and respect the indigenous culture and Te Tiriti O Waitangi, by developing bicultural responsiveness.\nApplying an autoethnographic critical research methodology I chart the shifts in my epistemology, ontology, and axiology, over the duration of this research. In this way I observe my own struggles to change my ‘ways of being’, by blending my academic, poetic and journal writing. Central to the dissertation are three articles published during the course of my doctoral research, which analyse the (re)formation of a counsellors’ professional association as a biculturally responsive organisation; the task of finding ‘common spaces’ that privilege cross-cultural ethics; and the use of Noho Marae in the (re)education of counsellors.\nThe research produced a shift in the researcher’s view of himself from being Pākehā to Tauiwi, and this change altered his perception of biculturalism and the Treaty of Waitangi. The autoethnographic research method was most suited to the task of in-depth personal analysis; and there emerged a view that the struggle to adopt counselling practices that are biculturally responsive, though difficult to achieve and prone to recidivism and regression, develops alongside the shift in an individual’s worldview and cultural identity. Non-Māori of all cultures need to collaborate with Māori, and in a three stage sequence, acknowledge our mistakes, make amends, and become wiser in the process. This thesis argues that, among other initiatives, the proposal by the counsellors’ association for bicultural consultation to become mandatory will assist with this development of bicultural responsiveness through increased opportunities for interaction and dialogue. This will create ways of deconstructing dualism and advantaging holistic views of health by reintegrating all aspects of well being; as envisioned by the concept of Hauora.
Plant genetic engineering may help with environmental cleanup. (1996)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Application of Interactive Classification System in University Study Course Comparison (2015)

The growing amount of information in the world has increased the need for computerized classification of different objects. This situation is present in higher education as well where the possibility of effortless detection of similarity between different study courses would give the opportunity to organize student exchange programmes effectively and facilitate curriculum management and development. This area which currently relies on manual time-consuming expert activities could benefit from application of smartly adapted machine learning technologies. Data in this problem domain is complex leading to inability for automatic classification approaches to always reach the desired result in terms of classification accuracy. Therefore, our approach suggests an automated/semi-automated classification solution, which incorporates both machine learning facilities and interactive involvement of a domain expert for improving classification results. The system's prototype has been implemented and experiments are carried out. This interactive classification system allows to classify educational data, which often comes in unstructured or semi-structured, incomplete and/or insufficient form, thus reducing the number of misclassified instances significantly in comparison with the automatic machine learning approach.
A GaAs distributed IMPATT diode amplifier (1984)

Stable microwave amplification has been obtained in GaAs distributed IMPATT (DIMPATT) diodes by the use of shorter than resonant length devices and appropriate input/output port terminations. CW output powers of 2 W were achieved at 9.5 GHz with 10-dB gain.
Turning Magnetic Density Separation into Green Business Using the Cyclic Innovation Model (2010)

The industrial implementation of Magnetic Density Separation (MDS) in the recycling of raw materials requires more than just the science of understanding why it works ('know-why') and the technology of how that can be accomplished ('know-how'). In addition, detailed knowledge of the market for streams of end-of-life products (supply side) and the market for recycled raw materials (demand side) are paramount to optimize the practical implementation and the design of an industrial plant. Indeed, in such a plant MDS is used to separate mixed streams of recycled materials into product streams which comply with market demands on grade and purity of the product compared with virgin streams. A recently developed non-linear innovation model is used to connect four fundamental cycles which continuously interact in the process of turning MDS technology into green business. The strength of this Cyclic Innovation Model lies in connecting technical capabilities with societal market needs. Only when a good match between the two is found a new technology such as, MDS develop into an innovation. The separation of polyolefins from end-of-life product is selected as one of the first industrial-sized applications of MDS in recycling. CIM is used to identify opportunities and challenges which need to be addressed to turn the MDS technology into an innovation that builds an economically attractive business in the context of a green society.
Globus platform‐as‐a‐service for collaborative science applications (2014)

Globus, developed as Software-as-a-Service (SaaS) for research data management, also provides APIs that constitute a flexible and powerful Platform-as-a-Service (PaaS) to which developers can outsource data management activities such as transfer and sharing, as well as identity, profile and group management. By providing these frequently important but always challenging capabilities as a service, accessible over the network, Globus PaaS streamlines web application development and makes it easy for individuals, teams, and institutions to create collaborative applications such as science gateways for science communities. We introduce the capabilities of this platform and review representative applications.
Transcatheter intravascular coil occlusion of experimental arteriovenous fistulas (1977)

Fistulas were surgically created between the carotid artery and jugular vein in dogs. They were successfully occluded by means of transcatheter placement of stainless steel coils with attached woolen strands. Angiographic studies performed prior to, immediately after, and 4 weeks after occlusion were used to evaluate the efficacy of the procedure. Specimens excised 4 weeks after occlusion revealed fibrotic encasement of the coil in the fistula, forming a permanent occlusion. The technique has clinical application, and suggestions concerning its clinical use are presented based on information gained from the animal study.
Tomato yellow leaf curl virus from sardinia is a whitefly- transmitted monoparatite geminivirus (1991)

The genome of an isolate of tomato yellow leaf curl virus from Sardinia, Italy (TYLCV-S), a geminivirus transmitted by the whitefly Bemisia tabaci, has been cloned and sequenced. The single circular DNA molecule comprises 2770 nucleotides. Genome organisation closely resembles that of the DNA A component of the whitefly-transmitted geminiviruses with a bipartite genome. A 1.8 mer of the TYLCV-S genome in a binary vector of Agrobacterium tumefaciens is infectious upon agroinoculation of tomato plants. Typical tomato yellow leaf curl disease symptoms developed about three weeks after inoculation. The disease was transmitted by the natural vector B.tabaci from agroinfected plants to test plants, reproducing in this way the full biological cycle and proving that the genome of TYLCV-S consists of only one circular single-stranded DNA molecule. Contrary to the other whitefly-transmitted geminiviruses described so far, there is no evidence for the existence nor the necessity of a second component (B DNA) in the TYLCV-S genome.
T-cell responses to peptide fragments of the BK virus T antigen: implications for cross-reactivity of immune response to JC virus (2006)

Infection with BK virus (BKV) induces both humoral and cellular immunity, but the viral antigens of T-antigen (T-ag) stimulating T-cell responses are largely unknown. To identify BKV-specific T cells in healthy individuals, peripheral blood lymphocytes were cultured with autologous dendritic cells (DCs) loaded with BKV lysate and T cells were screened for intracellular gamma interferon production after stimulation with an overlapping 15mer peptide library of the BKV T-ag. Among many immunogenic peptides identified, four T-ag peptides were identified as candidate major histocompatibility complex class I and II T-cell epitopes, restricted to human leukocyte antigen (HLA)-B*0702, -B*08, -DRB1*0301 and -DRB1*0901. Further, a candidate 9mer peptide, LPLMRKAYL, was confirmed to be restricted to HLA-B*0702 and -B*08. Because the polyomaviruses BKV, JC virus (JCV) and Simian virus 40 (SV40) share extensive sequence similarity in the immunogenic proteins T-ag and VP1, it was hypothesized that, in humans, these proteins contain conserved cytotoxic T-lymphocyte (CTL) target epitopes. Four HLA-restricted conserved epitopes of BKV, JCV and SV40 were identified: HLA-B*07, -B*08 and -DRB1*0901 for T-ag and -A*0201 for VP1. T cells cultured in vitro that were specific for one viral antigen recognized other conserved epitopes. CTLs generated from BKV T-ag and VP1 peptide were cytotoxic to DC targets pulsed with either BKV or JCV. Therefore, infection by one of the two viruses (BKV and JCV) could establish cross-immunity against the other. Although cross-cytotoxicity experiments were not performed with SV40, cross-recognition data from conserved antigen epitopes of polyomaviruses suggest strongly that cross-immunity might also exist among the three viruses.
Treatment of Antibody‐Associated Sperm With Media Containing High Serum Content: A Prospective Trial of Fertility Involving Men With High Antisperm Antibodies Following Intrauterine Insemination (1994)

Our data suggests that SM collection alters immunobead detectable ASA binding. Localization of ASA binding sites suggests that head-bound antibodies are influenced by SM treatment with little effect on tail-bound antibodies. In spite of the significant reduction of ASAs present on the sperm following SM treatment, there was no influence on pregnancy rates.
Factors Influencing the Embrittlement of Cold Worked High Alloy Materials in H2S Environments (1977)

The resistance of several high strength nickel and cobalt base alloys to embrittlement in aqueous H2S containing environments was examined. The alloys evaluated were Hastelloy Alloy C-276 and Alloy C-4, Inconel 625, and MP35N. All materials were received as tubing in the cold reduced condition and were subjected to various heat treatments ranging from 148 to 593 C (300 to 1100 F) for times from 10 minutes to over 500 hours. The effect on cracking susceptibility of: (1) cold working, (2) aging time and temperature, (3) sample orientation, (4) galvanic interaction with steel, and (5) environmental temperature and composition were determined. It was found that aging for very short periods at high temperature [482 to 593 C (900 to 1100 F)/10 minutes] or for longer times at low temperatures [148 to 204 C (300 to 400 F)/~500 hours] significantly reduced the resistance of these materials to hydrogen embrittlement. This behavior was greatly dependent on galvanic interaction with steel and on sample orientation. Failures were limited to samples that were coupled to steel and stressed in the transverse direction. No failures were observed in any longitudinally stressed specimens, even under very severe testing conditions, or in transversely stressed specimens without steel couples. Elevated temperature environments were beneficial in reducing the susceptibility to cracking and brittle failure. The results of these tests are discussed in terms of hydrogen embrittlement. Also, the metallurgical reactions occurring during aging are examined to determine their possible role in the hydrogen embrittlement behavior of these materials.
Amber: Enabling Precise Full-System Simulation with Detailed Modeling of All SSD Resources (2018)

SSDs become a major storage component in modern memory hierarchies, and SSD research demands exploring future simulation-based studies by integrating SSD subsystems into a full-system environment. However, several challenges exist to model SSDs under a full-system simulations; SSDs are composed upon their own complete system and architecture, which employ all necessary hardware, such as CPUs, DRAM and interconnect network. Employing the hardware components, SSDs also require to have multiple device controllers, internal caches and software modules that respect a wide spectrum of storage interfaces and protocols. These SSD hardware and software are all necessary to incarnate storage subsystems under full-system environment, which can operate in parallel with the host system. In this work, we introduce a new SSD simulation framework, SimpleSSD 2.0, namely Amber, that models embedded CPU cores, DRAMs, and various flash technologies (within an SSD), and operate under the full system simulation environment by enabling a data transfer emulation. Amber also includes full firmware stack, including DRAM cache logic, flash firmware, such as FTL and HIL, and obey diverse standard protocols by revising the host DMA engines and system buses of a popular full system simulator's all functional and timing CPU models (gem5). The proposed simulator can capture the details of dynamic performance and power of embedded cores, DRAMs, firmware and flash under the executions of various OS systems and hardware platforms. Using Amber, we characterize several system-level challenges by simulating different types of full-systems, such as mobile devices and general-purpose computers, and offer comprehensive analyses by comparing passive storage and active storage architectures.
The Chloromethylation of 5-Nitrosalicylaldehyde (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chloromethylation of 5-NitrosalicylaldehydeLloyd D. Taylor and Robert B. DavisCite this: J. Org. Chem. 1963, 28, 6, 1713Publication Date (Print):June 1, 1963Publication History Published online1 May 2002Published inissue 1 June 1963https://pubs.acs.org/doi/10.1021/jo01041a512https://doi.org/10.1021/jo01041a512research-articleACS PublicationsRequest reuse permissionsArticle Views441Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Glare sensitivity and visual acuity after excimer laser photorefractive keratectomy for myopia (1997)

Disability glare and a reduction in contrast sensitivity could be observed in most patients after PRK treatment with the Meditec laser system with its scanning slit. The future will show if new technology and a broader flattening area of 6 to 7 mm can minimise these postoperative complications.
Relational databases for SSC design and control (2003)

To respond to SSC (Superconducting Supercollider) data processing needs, a number of techniques, utilities, and libraries are being developed. They will allow efficient and well-managed transfer of data between the database and scientific data-collection, display, and analysis programs. They use a commercial relational database management system, Sybase, running on a Sun 2-280 dataserver, and a data discipline, SDS (self describing standard), which attaches format and context information to datasets wherever they are. Two applications are considered: management of, and access to, raw and analyzed test data from the magnet R&D laboratories and management and integrity control of the lattice design databases.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reliability modeling of gas and electric power distribution systems; similarities and differences (2006)

Due to the introduction of alternative energy carriers, such as district heating and natural gas, the Norwegian energy system is becoming more complex. Assessing the reliability of electrical distribution systems is a mature field of research, but limited work has been carried out concerning the reliability of distribution systems for alternative energy carriers. This paper proposes a methodology for assessing the reliability of natural gas distribution systems based on experiences drawn from similar analysis of electrical power distribution systems. A simple test case is presented for illustrative purposes and the basic load-point reliability indices of average interruption rate, average outage time and average annual outage time are found