gebhart/patrepeval huggingface dataset:
The stroma of higher plant plastids contain ClpP and ClpC, functional homologs of Escherichia coli ClpP and ClpA: an archetypal two-component ATP-dependent protease. (1995)

A cDNA representing the plastid-encoded homolog of the prokaryotic ATP-dependent protease ClpP was amplified by reverse transcription-polymerase chain reaction, cloned, and sequenced. ClpP and a previously isolated cDNA designated ClpC, encoding an ATPase related to proteins encoded by the ClpA/B gene family, were expressed in Escherichia coli. Antibodies directed against these recombinant proteins recognized proteins in a wide variety of organisms. N-terminal analysis of the Clp protein isolated from crude leaf extracts showed that the N-terminal methionine is absent from ClpP and that the transit peptide is cleaved from ClpC. A combination of chloroplast subfractionation and immunolocalization showed that in Arabidopsis, ClpP and ClpC localize to the stroma of the plastid. Immunoblot analyses indicated that ClpP and ClpC are constitutively expressed in all tissues of Arabidopsis at levels equivalent to those of E. coli ClpP and ClpA. ClpP, immunopurified from tobacco extracts, hydrolyzed N-succinyl-Leu-Tyr-amidomethylcoumarin, a substrate of E. coli ClpP. Purified recombinant ClpC facilitated the degradation of 3H-methylcasein by E. coli ClpP in an ATP-dependent fashion. This demonstrates that ClpC is a functional homolog of E. coli ClpA and not of ClpB or ClpX. These data represent the only in vitro demonstration of the activity of a specific ATP-dependent chloroplast protease reported to date.
Automatic Counterflow Detection in Subway Corridors by Image Processing (2001)

The purpose of our study is to provide an automatic tool for the detection of abnormal individual or crowd motion in subway corridors, in particular counterflows in one way corridors. First, we developed a motion estimation method that takes into account two difficulties: real time constraint and non-rigid moving objects (the pedestrians). We chose three techniques, for this purpose. Each belongs to a specific class of methods. These are block matching (matching technique), optical flow (differential technique) and Gabor filtering (frequential technique). We then attempted to improve both the speed and performance of each algorithm. As a result, we produced a very efficient optical flow technique. The obtained motion vectors were then filtered and used for the construction of motion trajectories. The trajectories were finally used to detect counterflows.
The Population Dynamics, Ecological and Seasonal Activity of Paederus fuscipes Curtis (Staphylinidae; Coleoptera) in the Punjab, Pakistan (2012)

Inspite of its multiferious (scavenger, predator and medical importance) role which it plays in the ecosystem, its ecology is rarely investigated. So, the present study aims to investigate and relate Paederus fuscipes assemblages to cultivated soils and forest parameters of the Punjab, Pakistan during 2008-2009 with six different collecting methods (pitfall traps, light traps, flight intercept traps, Berlese funnel traps, sweep net and visual observation). Maximum population was collected with the help of pitfall trap. It was recorded only from cropped areas mainly having decayed organic matter. Not a single individual was recorded from forest areas. It was mainly recorded from maize (Zea maize) and berseem (Trifolium alexandrinum) crops due to presence of soft bodied insects. It preferred damp soil rich in organic matter for egg laying under natural conditions. Maximum activity was observed near the ground. Maximum population was recorded during March and July-August. Light had attractive effect on it, so maximum activity was observed during night also. Its activity is greatly influenced by light and soil moisture contents.
RasGRP1 Is Required for Human NK Cell Function (2009)

Cross-linking of NK activating receptors activates phospholipase-gamma and subsequently induces diacylglycerol and Ca(2+) as second messengers of signal transduction. Previous studies reported that Ras guanyl nucleotide-releasing protein (RasGRP) 1, which is activated by diacylglycerol and Ca(2+), is crucial for TCR-mediated Ras-ERK activation. We now report that RasGRP1, which can also be detected in human NK cells, plays an essential role in NK cell effector functions. To examine the role of RasGRP1 in NK cell functions, the expression of RasGRP1 was suppressed using RNA interference. Knockdown of RasGRP1 significantly blocked ITAM-dependent cytokine production as well as NK cytotoxicity. Biochemically, RasGRP1-knockdown NK cells showed markedly decreased ability to activate Ras, ERK, and JNK. Activation of the Ras-MAPK pathway was independently shown to be indispensable for NK cell effector functions via the use of specific pharmacological inhibitors. Our results reveal that RasGRP1 is required for the activation of the Ras-MAPK pathway leading to NK cell effector functions. Moreover, our data suggest that RasGRP1 might act as an important bridge between phospholipase-gamma activation and NK cell effector functions via the Ras-MAPK pathway.
Outcomes of Patients Admitted for Observation of Chest Pain (2012)

Most patients who are admitted with low-risk chest pain undergo stress testing, regardless of pretest probability, but abnormal test results are uncommon and rarely acted on. Ordering stress tests based on pretest probability could improve efficiency without endangering patients.
Therapeutic efficiency of topiramate alone and co-administration in children epilepsy (2005)

topiramate was used in 69 children with newly diagnosed epilepsy or as supplementary therapy for those poorly controlled patients frequency of after full dose toprimate was studied based on episode 3 month before topiramate therapy or ≥2 times episode patients and then calculate effective percentage. The total effectiveness of topiramate for childhood epilepsy is 85.5% with 56.5% in topiramate use alone and 52.2% in those of topiramate supplement therapy. There is 33.3% cases.in minor manifestation except 2 with frequent onset. Topiramate may be used as a first line drug for childhood epilepsy for its effectiveness and safety.
3D Graphitic Foams Derived from Chloroaluminate Anion Intercalation for Ultrafast Aluminum‐Ion Battery (2016)

A 3D graphitic foam vertically aligned graphitic structure and a low density of defects is derived through chloroaluminate anion intercalation of graphite followed by thermal expansion and electrochemical hydrogen evolution. Such aligned graphitic structure affords excellent Al-ion battery characteristics with a discharge capacity of ≈60 mA h g<sup>-1</sup> under a high charge and discharge current density of 12 000 mA g<sup>-1</sup> over ≈4000 cycles.
Experimental performance data for slowed-down adaptive algorithms† (1982)

Abstract Considerable savings in hardware and computation time can be achieved very simply by slowing down the adaptive algorithm for an adaptive digital filter either by updating weights loss often than every sample (typically every n samples, where n is the number of fitter weights), or by updating only one weight per sample cyclically repeating every n samples. This technique has the advantage of being useful with any of the many adaptive algorithms including the LMS non-recursive algorithm and the Stearns-White recursive algorithm. Experiments verify that the slowed down algorithms not only save hardware and computation time, but actually improve filter performance. Notes †This work was supported in part by the United States Air Force Office of Scientific Research (AFOSR) under Grant AFOSR800189. Additional informationNotes on contributorsM. C. VIGIL M. C. Vigil now with Hewlett-Packard, Santa Clara, CA, J. J. Buteau now with Dictaphone Corp., South Norwalk, CT, and J. K. Kelley now with Link-A-Bit Corp., San Diego, CA.
Consistency of the EKF-SLAM Algorithm (2006)

This paper presents an analysis of the extended Kalman filter formulation of simultaneous localisation and mapping (EKF-SLAM). We show that the algorithm produces very optimistic estimates once the "true" uncertainty in vehicle heading exceeds a limit. This failure is subtle and cannot, in general, be detected without ground-truth, although a very inconsistent filter may exhibit observable symptoms, such as disproportionately large jumps in the vehicle pose update. Conventional solutions - adding stabilising noise, using an iterated EKF or unscented filter, etc., - do not improve the situation. However, if "small" heading uncertainty is maintained, EKF-SLAM exhibits consistent behaviour over an extended time-period. Although the uncertainty estimate slowly becomes optimistic, inconsistency can be mitigated indefinitely by applying tactics such as batch updates or stabilising noise. The manageable degradation of small heading variance SLAM indicates the efficacy of submap methods for large-scale maps
A Primal-Dual Randomized Algorithm for Weighted Paging (2012)

We study the weighted version of the classic online paging problem where there is a weight (cost) for fetching each page into the cache. We design a randomized O (log k )-competitive online algorithm for this problem, where k is the cache size. This is the first randomized o ( k )-competitive algorithm and its competitive ratio matches the known lower bound for the problem, up to constant factors. More generally, we design an O (log( k /( k − h + 1)))-competitive online algorithm for the version of the problem where the online algorithm has cache size k and it is compared to an optimal offline solution with cache size h ≤ k . Our solution is based on a two-step approach. We first obtain an O (log k )-competitive fractional algorithm based on an online primal-dual approach. Next, we obtain a randomized algorithm by rounding in an online manner the fractional solution to a probability distribution on the possible cache states. We also give an online primal-dual randomized O (log N )-competitive algorithm for the Metrical Task System problem (MTS) on a weighted star metric on N leaves.
A late embryogenesis abundant protein <scp>HVA</scp>1 regulated by an inducible promoter enhances root growth and abiotic stress tolerance in rice without yield penalty (2014)

Regulation of root architecture is essential for maintaining plant growth under adverse environment. A synthetic abscisic acid (ABA)/stress-inducible promoter was designed to control the expression of a late embryogenesis abundant protein (HVA1) in transgenic rice. The background of HVA1 is low but highly inducible by ABA, salt, dehydration and cold. HVA1 was highly accumulated in root apical meristem (RAM) and lateral root primordia (LRP) after ABA/stress treatments, leading to enhanced root system expansion. Water-use efficiency (WUE) and biomass also increased in transgenic rice, likely due to the maintenance of normal cell functions and metabolic activities conferred by HVA1 which is capable of stabilizing proteins, under osmotic stress. HVA1 promotes lateral root (LR) initiation, elongation and emergence and primary root (PR) elongation via an auxin-dependent process, particularly by intensifying asymmetrical accumulation of auxin in LRP founder cells and RAM, even under ABA/stress-suppressive conditions. We demonstrate a successful application of an inducible promoter in regulating the spatial and temporal expression of HVA1 for improving root architecture and multiple stress tolerance without yield penalty.
Genomic organization, chromosomal localization, and developmentally regulated expression of the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei. (1990)

The surface of the bloodstream form of the African trypanosome, Trypansoma brucei, is covered with about 10(7) molecules of the variant surface glycoprotein (VSG), a protein tethered to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) membrane anchor. This anchor is cleavable by an endogenous GPI-specific phospholipase C (GPI-PLC). GPI-PLC activity is down regulated when trypanosomes differentiate from the bloodstream form to the procyclic form found in the tsetse fly vector. We have mapped the GPI-PLC locus in the trypanosome genome and have examined the mechanism for this developmental regulation in T. brucei. Southern blot analysis indicates a single-copy gene for GPI-PLC, with two allelic variants distinguishable by two NcoI restriction fragment length polymorphisms. The gene was localized solely to a chromosome in the two-megabase compression region by contour-clamped homogeneous electric field gel electrophoresis. No rearrangement of the GPI-PLC gene occurs during differentiation to procyclic forms, which could potentially silence GPI-PLC gene expression. Enzymological studies give no indication of a diffusible inhibitor of GPI-PLC activity in procyclic forms, and Western immunoblot analysis reveals no detectable GPI-PLC polypeptide in these forms. Therefore, it is highly unlikely that the absence of GPI-PLC activity in procyclic forms is due to posttranslational control. Northern (RNA) blot analysis reveals barely detectable levels of GPI-PLC mRNA in procyclic forms; therefore, regulation of GPI-PLC activity in these forms correlates with the steady-state mRNA level.
Optical Waveform Probing – Strategies for Non-Fllpchlp Devices and Other Applications (2001)

Abstract Optical waveform probing is a critical component in flipchip diagnostics. There is a dramatic increase in the need for backside silicon probing of non-flipchip packaged devices. The effective way to implement this strategy is to package the die in a BGA carrier that allows backside analysis. Optical waveform probing has been used primarily as a digital waveform timing analysis tool. The capability of optical waveform probers can be extended to failsite isolation and qualitative analog signal analysis.
Advanced automatic train protection system (2002)

Presents a new automatic train protection system. Such messages as the distance to the preceding train or the speed restriction on switches are transmitted to each train instead of the limit speed set for the train. This is done through the rails using digital codes. An on-board processor generates a braking pattern using these messages and the braking performance. And if the speed exceeds the calculated value, the brake is applied. As this system controls the train speed in one step from full speed to stop, it can shorten the train headway. And it can effectively cope with a mixture of trains with different braking performances.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Site-specific mutagenesis of murine anti-human TNF-alpha Fab gene and its expression in E.coli]. (2003)

We get soluble expression products of humanized Fab, which provides a sound basis for future research on its activity and purification.
Bioelectrical impedance phase angle as a prognostic indicator in breast cancer (2008)

This study demonstrates that BIA-derived phase angle is an independent prognostic indicator in patients with breast cancer. Nutritional interventions targeted at improving phase angle could potentially lead to an improved survival in patients with breast cancer.
One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing (2016)

The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects the genetic information of animal germ cells from the deleterious effects of molecular parasites, such as transposons. Discovered nearly a decade ago, this small RNA silencing system comprises PIWI-clade Argonaute proteins and their associated RNA-binding partners, the piRNAs. In this review, we highlight recent work that has advanced our understanding of how piRNAs preserve genome integrity across generations. We discuss the mechanism of piRNA biogenesis, give an overview of common themes as well as differences in piRNA-mediated silencing between species, and end by highlighting known and emerging functions of piRNAs.
Enhancement of Chemotherapeutic Efficacy by Small Molecule Inhibition of NF-&#954; B and Checkpoint Kinases (2007)

Apoptosis or programmed cell death is a cellular mechanism used to regulate cell number and eliminate damaged or mutated cells. Many chemotherapeutic agents and ionizing radiation induce not only apoptotic signaling pathways, but also survival responses such as DNA damage responses and cell cycle arrest, which allow for DNA repair. These survival responses determine the toxicity as well as the efficacy of the cancer treatment. Two main DNA damage responses include the activation of the anti-apoptotic transcription factor NF-kappaB and the activation of cell cycle checkpoint kinases. Strategies of combining chemotherapeutics with (a) inhibitors of NF-kappaB or (b) inhibitors of checkpoint kinases, may therefore enhance the efficacy of current cancer therapies. This review will be focused on recent progress made in combining traditional chemotherapeutic drugs with small molecule inhibitors of NF-kappaB and the checkpoint kinases, Chk1 and Chk2.
LSP Modification Using CR-LDP (2002)

This document presents an approach to modify the bandwidth and possibly other parameters of an established CR-LSP (Constraint-based Routed Label Switched Paths) using CR-LDP (Constraint-based Routed Label Distribution Protocol) without service interruption. After a CR-LSP is set up, its bandwidth reservation may need to be changed by the network operator, due to the new requirements for the traffic carried on that CR-LSP. The LSP modification feature can be supported by CR-LDP by use of the _modify_value for the _action indicator flag_ in the LSPID TLV. This feature has application in dynamic network resources management where traffic of different priorities and service classes is involved.
Learning More with Less (2019)

Accurate Computer-Assisted Diagnosis, associated with proper data wrangling, can alleviate the risk of overlooking the diagnosis in a clinical environment. Towards this, as a Data Augmentation (DA) technique, Generative Adversarial Networks (GANs) can synthesize additional training data to handle the small/fragmented medical imaging datasets collected from various scanners; those images are realistic but completely different from the original ones, filling the data lack in the real image distribution. However, we cannot easily use them to locate disease areas, considering expert physicians' expensive annotation cost. Therefore, this paper proposes Conditional Progressive Growing of GANs (CPGGANs), incorporating highly-rough bounding box conditions incrementally into PGGANs to place brain metastases at desired positions/sizes on 256 X 256 Magnetic Resonance (MR) images, for Convolutional Neural Network-based tumor detection; this first GAN-based medical DA using automatic bounding box annotation improves the training robustness. The results show that CPGGAN-based DA can boost 10% sensitivity in diagnosis with clinically acceptable additional False Positives. Surprisingly, further tumor realism, achieved with additional normal brain MR images for CPGGAN training, does not contribute to detection performance, while even three physicians cannot accurately distinguish them from the real ones in Visual Turing Test.
Stabilization of xLi[sub 2]MnO[sub 3]⋅(1−x)LiMO[sub 2] Electrode Surfaces (M=Mn, Ni, Co) with Mildly Acidic, Fluorinated Solutions (2008)

It has been demonstrated previously that -stabilized electrodes [, , , ] can provide anomalously high electrochemical capacities if charged to high potentials . High-voltage charging results in an irreversible capacity loss on the initial charge/discharge cycle; it also damages the electrode surface, leading to a high cell impedance. In this paper, we report that preconditioning electrode powders [alternatively in notation] with extremely mild acidic solutions of , , and salts in water and methanol (pH 6–6.5) leads to remarkable cycling stability of both lithium half-cells and full lithium-ion cells when repeatedly charged to high voltages . The enhanced electrochemical performance is attributed to stabilized electrode surfaces that are etched and passivated by fluorinated species. The low-temperature behavior of unconditioned and preconditioned electrodes is presented.
Electron Distribution in Molecules. II. Proton and Fluorine Magnetic Resonance Shifts in the Halomethanes (1953)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTElectron Distribution in Molecules. II. Proton and Fluorine Magnetic Resonance Shifts in the HalomethanesL. H. Meyer and H. S. GutowskyCite this: J. Phys. Chem. 1953, 57, 5, 481–486Publication Date (Print):May 1, 1953Publication History Published online1 May 2002Published inissue 1 May 1953https://pubs.acs.org/doi/10.1021/j150506a001https://doi.org/10.1021/j150506a001research-articleACS PublicationsRequest reuse permissionsArticle Views202Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Supporting Mixed Presence Groupware in Tabletop Applications (2006)

In this paper, we present the transparent input device layer framework to extend Java applications with support for multiple distributed input devices, a major requirement for tabletop applications. This overcomes a key restriction of current graphical environments to support only a single system cursor and one keyboard, and allows the cursor and keyboard control of applications to be performed by input devices that are connected to other hosts on the network. Applications can be developed with this framework and therefore allow operations such as simultaneous drag and drop by multiple users. Additionally, we have created a wrapper application to inject support for multiple input devices into legacy applications at runtime - without the need for code alteration or recompilation. We present two tabletop applications that make use of our framework: one is a graphical front end to a military course of action scheduling application and was developed with the framework. The second application, a component based data visualisation application, employs the injection wrapper application to gain support for distributed multiple input devices at runtime.
ADP dissociation from actomyosin subfragment 1 is sufficiently slow to limit the unloaded shortening velocity in vertebrate muscle. (1985)

The rate constant for dissociation of ADP from actomyosin subfragment 1 (S1) has been measured in this laboratory and elsewhere for a variety of vertebrate muscle types. We have made the following observations: (i) In solution, the dissociation of ADP from actomyosin-S1 limits the rate of dissociation of actomyosin-S1-ADP by ATP and, presumably, also limits the rate of crossbridge detachment in contracting muscle. (ii) For muscle types in which the rate of ADP dissociation from actomyosin-S1 is slow enough to measure using stopped-flow methods, the rate constants are nearly the same as the theoretical value for the minimum allowable rate constant for dissociation of an attached crossbridge. Therefore, ADP dissociation is sufficiently slow to be the molecular step that limits the maximum shortening velocity of these muscles. (iii) Variation with muscle type of the rate constant for ADP dissociation may be a general phylogenetic mechanism for regulating shortening velocity.