gebhart/patrepeval huggingface dataset:
Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: role of the S1 and M2 genes (1996)

The mammalian reoviruses are capable of inhibiting cellular DNA synthesis and inducing apoptosis. Reovirus strains type 3 Abney (T3A) and type 3 Dearing (T3D) inhibit cellular DNA synthesis and induce apoptosis to a substantially greater extent than strain type 1 Lang (T1L). We used T1L x T3A and T1L x T3D reassortant viruses to identify viral genes associated with differences in the capacities of reovirus strains to elicit these cellular responses to viral infection. We found that the S1 and M2 genome segments determine differences in the capacities of both T1L x T3A and T1L x T3D reassortant viruses to inhibit cellular DNA synthesis and to induce apoptosis. These genes encode viral outer-capsid proteins that play important roles in viral attachment and disassembly. To extend these findings, we used field isolate strains of reovirus to determine whether the strain-specific differences in inhibition of cellular DNA synthesis and induction of apoptosis are also associated with viral serotype, a property determined by the S1 gene. In these experiments, type 3 field isolate strains were found to inhibit cellular DNA synthesis and to induce apoptosis to a greater extent than type 1 field isolate strains. Statistical analysis of these data indicate a significant correlation between the capacity of T1L x T3A and T1L x T3D reassortant viruses and field isolate strains to inhibit cellular DNA synthesis and to induce apoptosis. These findings suggest that reovirus-induced inhibition of cellular DNA synthesis and induction of apoptosis are linked and that both phenomena are induced by early steps in the viral replication cycle.
Effect of Helium-Neon Laser on Musculoskeletal Trigger Points (1986)

Cold lasers have been proposed recently as a therapeutic tool for treating a wide variety of pathological conditions, including wounds, arthritis, orthopedic problems, and pain. These proposed therapeutic effects largely have been unsubstantiated by research. A randomized, double blind study was undertaken to ascertain the effect of a helium-neon (He-Ne) laser on the resistance of areas of skin overlying musculoskeletal trigger points. These areas usually demonstrate decreased skin resistance when compared with the surrounding tissue. Thirty patients with musculoskeletal trigger points were assigned randomly to either an experimental or a placebo group. In addition to standard physical therapy, each patient received three 15-second applications of a He-Ne laser or placebo "stimulation" from an identical unit that did not emit a laser. The results of a two-way analysis of covariance with one repeated measure showed a statistically significant increase (p less than .007) in skin resistance. This increase in an abnormal skin resistance pattern may accompany the resolution of pathological conditions.
Cross-Talk Limits of Highly Segmented Semiconductor Detectors (2011)

Cross-talk limits of monolithic highly-segmented semiconductor detectors for high-resolution X-gamma spectrometry are investigated. Cross-talk causes false signal components yielding amplitude losses and fold-dependent shifts of the spectral lines, which partially spoil the spectroscopic performance of the detector. Two complementary electrical models are developed, which describe quantitatively the inter-channel cross-talk of monolithic segmented detectors whose electrodes are read out by charge-sensitive preamplifiers. The first is here designated as Cross-Capacitance (CC) model, the second as Split-Charge (SC) model. The CC model builds around the parasitic capacitances C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ij</sub> linking the preamplifier outputs and the neighbor channel inputs. The SC model builds around the finite-value of the decoupling capacitance C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</sub> used to read out the high-voltage detector electrode. The key parameters of the models are individuated and ideas are shown to minimize their impact. Using a quasi-coaxial germanium segmented detector it is found that the SC cross-talk becomes negligible for decoupling capacitances larger than 1 nF, where instead the CC cross-talk tends to dominate. The residual cross-talk may be reduced by minimization of stray capacitances C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ij</sub> , through a careful design of the layout of the Printed Circuit Board (PCB) where the input transistors are mounted. C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ij</sub> can be made as low as ~5 fF, but it is shown that even in such case the impact of the CC cross-talk on the detector performance is not negligible. Finally, an algorithm for cross-talk correction is presented and elaborated.
THE PHARMACOLOGY OF PANCURONIUM BROMIDE (ORG.NA97), A NEW POTENT STEROIDAL NEUROMUSCULAR BLOCKING AGENT (1968)

The incorporation of a biologically active group into a naturally occurring structure is an interesting approach to new pharmacological agents. For example, when an acetylcholine-like structure is incorporated in ring-A of 5a-androstane-17-one or 5a-pregnan-20-one, neuromuscular blocking agents of up to one-fifteenth the potency of tubocurarine are obtained (Lewis, Martin-Smith, Muir & Ross, 1967). Although of limited clinical value, such compounds present useful leads for further chemical exploration, particularly the synthesis of bisquaternary amino-steroidal salts. A series of 2,8,16,3-diamino-5a-androstane-3a,17p-diol dimethohalide derivatives was described by Buckett, Hewett & Savage (1967). One of them, 2ft,16,/-dipiperidino-5a-androstane-3a,17,8-diol diacetate dimethobromide (code number Org.NA97; approved name pancuronium bromide), is a potent neuromuscular blocking agent and in the experiments described in this paper its actions were compared with those of tubocurarine chloride. OAc ",,MeI N Me Acd H 2Br-,H20 METHODS Nerve-muscle preparations
The Short-Term Effects of High-Dose Testosterone on Sleep, Breathing, and Function in Older Men (2003)

Androgen therapy may precipitate obstructive sleep apnea in men. Despite increasing androgen use in older men, few studies have examined sleep and breathing. Randomized, double-blind, placebo-controlled studies examining effects of testosterone simultaneously on sleep, breathing, and function in older men are not available. Seventeen community-dwelling healthy men over the age of 60 yr were randomized to receive three injections of im testosterone esters at weekly intervals (500 mg, 250 mg, and 250 mg) or matching oil-based placebo and then crossed over to the other treatment after 8 wk of washout. Polysomnography, anthropometry, and physical, mental, and metabolic function were assessed at baseline and after each treatment period. Testosterone treatment reduced total time slept ( approximately 1 h), increased the duration of hypoxemia ( approximately 5 min/night), and disrupted breathing during sleep (total and non-rapid eye movement respiratory disturbance indices both increased by approximately seven events per hour) (all P < 0.05). Despite expected effects on body composition (increase in total and lean mass, reduction in fat mass, P < 0.05, bioimpedance method), upper airway dimensions did not change (acoustic reflectometry). Driving ability (computer simulation), physical activity (accelerometry, Physical Activity Scale in the Elderly), quality of life (SF36, Functional Outcomes of Sleep Questionnaire), mood (Profile of Mood States Questionnaire), sleepiness (Epworth, Stanford scales), and insulin resistance (homeostasis model) also were not changed by treatment. Short-term administration of high-dose testosterone shortens sleep and worsens sleep apnea in older men but did not alter physical, mental, or metabolic function. These changes did not appear to be due to upper airway narrowing. Further study of longer-term lower-dose androgen therapy on sleep and breathing is needed to evaluate its safety in older men.
Herbicide-tolerant Transgenic Pineapple (Ananas comosus) Produced by Microprojectile Bombardment (2001)

Transformed plants of the commercially important Thai pineapple (Ananas comosus `Phuket') were produced following microprojectile-mediated delivery of the plasmid AHC25, carrying the b-glucuronidase (gus) reporter gene and the bialaphos resistance (bar) gene for herbicide tolerance, into leaves of micropropagated shoots. Transformed plants were regenerated from bombarded leaf bases on Murashige and Skoog-based medium containing 0 . 5 mg l 1 2,4-dichlorophenoxyacetic acid, 2 . 0 mg l 1 6-benzylamino purine and 0 . 5 mg l 1 phosphinothricin. Integration and expression of the bar gene in regenerated plants was conrmed by Southern analysis and RT-PCR, respectively. Regenerated plants were assessed in vitro and under glasshouse conditions for their tolerance to the commercial herbicide Basta 2 , containing glufosinate ammonium as the active component. Plants sprayed with Basta 2 containing concentrations of glufosinate ammonium up to 1400 mg l 1 remained healthy and retained their pigmentation. The generation of herbicide-tolerant pineapple will facilitate more ecient weed control in this widely cultivated tropical crop.
Phenolic and sugar components of Armavireo variety sunflower (Helianthus annuus) seed meal (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhenolic and sugar components of Armavireo variety sunflower (Helianthus annuus) seed mealKenneth L. Mikolajczak, Cecil Randolph. Smith, Jr., and Iuan A. WolffCite this: J. Agric. Food Chem. 1970, 18, 1, 27–32Publication Date (Print):January 1, 1970Publication History Published online1 May 2002Published inissue 1 January 1970https://pubs.acs.org/doi/10.1021/jf60167a026https://doi.org/10.1021/jf60167a026research-articleACS PublicationsRequest reuse permissionsArticle Views198Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cornulin, a marker of late epidermal differentiation, is down‐regulated in eczema (2008)

CRNN mRNA expression is decreased in eczematous skin. Further studies are needed to verify whether the associated cornulin polymorphism contribute to the genetic susceptibility in eczema.
Subnanosecond electrical modulation of light with hydrogenated amorphous silicon (1981)

A silicon thin-film interferometer structure is used to demonstrate subnanosecond electrical modulation of light. Both thermally and electrically induced modulations are reported. An electrically induced change in refractive index of 4.7×10−4 is observed.
Review of underground coal gasification field experiments at Hoe Creek (1983)

In three underground coal gasification experiments at the Hoe Creek site near Gillette, WY, LLNL applied three different linking methods: explosive fracture, reverse burning, and directional drilling. Air was injected in all three experiments; a steam/oxygen mixture, during 2 days of the second and most of the third experiment. Comparison of results show that the type of linking method did not influence gas quality. The heat of combustion of the product gas was higher with steam/oxygen injection, mainly because of reduced inert diluent. Gas quality was generally independent of other operating parameters but declined from its initial value over a period of time because of heat loss to the wet overburden and extensive roof collapse in the second and third experiments.
Recyclable Hypervalent‐Iodine‐Mediated Dehydrogenative α,β′‐Bifunctionalization of β‐Keto Esters Under Metal‐Free Conditions (2015)

We have developed a method for recyclable hypervalent-iodine-mediated direct dehydrogenative α,β'- bifunctionalization of β-ketoesters and β-diketones under metal-free conditions, which affords a straightforward way to synthesize benzo-fused 2,3-dihydrofurans. This efficient, mild method, which has a wide substrate scope and good functional-group tolerance, was used for the multistep synthesis of the protected aglycone of a naturally occurring phenolic glycoside. A mechanism involving Michael addition to an enone intermediate and subsequent oxidative cyclization is proposed.
TinyChecker: Transparent protection of VMs against hypervisor failures with nested virtualization (2012)

The increasing amount of resources in a single machine constantly increases the level of server consolidation for virtualization. However, along with the improvement of server efficiency, the dependability of the virtualization layer is not being progressed towards the right direction; instead, the hypervisor level is more vulnerable to diverse failures due to the increasing complexity and scale of the hypervisor layer. This makes tens to hundreds of production VMs in a machine easily risk a single point of failure. This paper tries to mitigate this problem by proposing a technique called TinyChecker, which uses a tiny nested hypervisor to transparently protect guest VMs against failures in the hypervisor layer. TinyChecker is a very small software layer designated for transparent failure detection and recovery, whose reliability can be guaranteed by its small size and possible further formal verification. TinyChecker records all the communication context between VM and hypervisor, protects the critical VM data, detects and recovers the hypervisors among failures. TinyChecker is currently still in an early stage, we report our design consideration and initial evaluation results.
Purification, properties, and sequence specificity of SslI, a new type II restriction endonuclease from Streptococcus salivarius subsp. thermophilus (1991)

SslI, a type II restriction endonuclease, was purified from Streptococcus salivarius subsp. thermophilus strain BSN 45. SslI is an isoschizomer of BstNI. SslI activity was maximum at pH 8.8, 0 to 50 mM NaCl, 2 to 8 mM Mg2+, and 42 degrees C. Activity against phage DNA in vitro was demonstrated.
Effect of YSZ thin film coating thickness on the strength of a ceramic substrate (2007)

Although ceramics are used for many different biomedical applications they are brittle materials that can be compromised by surface defects when under stress. The objective of this study was to evaluate the effect of surface modification with an yttria-stabilized zirconia (YSZ) thin film coating on the strength of a machinable dental ceramic. Fifty bars (2 mm x 2 mm x 15 mm) were cut from ProCAD (Ivoclar-Vivadent) blocks. Specimens were wet-polished through 1200-grit SiC abrasive. One surface of each bar was sandblasted with 50 microm Al(2)O(3) abrasive (0.34 MPa). Specimens were further modified through the deposition of a sputtered YSZ thin film on the sandblasted surface. Different thin film thicknesses were evaluated: 1, 3, 5, and 7 microm. Depositions were performed using a radio frequency magnetron sputter system (working pressure of 15 mT, 150 degrees C, 30:1 Ar/O(2) gas ratio). Flexural strength measurements were carried out by three-point bending (span = 10 mm) in a servo-electric material testing system in DI water (37 degrees C). The results showed that the strength of porcelain significantly increased with the deposition of a 3-microm YSZ thick coating. A nonlinear relationship was observed between film thickness and strength. Strengthening of porcelain is shown through the application of a sputtered YSZ thin film. It is presumed that the strengthening mechanism is due to modification of surface flaws and/or surface residual stress by the applied thin film.
Chemistry of Polymers (1997)

The Chemistry of Polymers, 5th Edition, is fully updated with the latest developments in polymer science providing a highly readable textbook for those requiring a broad overview of the subject. Like previous editions, the book continues to explore the subject from an applications point of view, providing a comprehensive introduction to all aspects of polymer science including synthesis, structure, properties, degradation and dendrimers. Recent advances in special topics in polymer chemistry and polymers and the environment are also discussed in an informative and up-to-date manner. The new edition features additional content on recent developments in new polymer synthesis techniques including reversible addition-fragmentation chain transfer (RAFT) polymerization, atom transfer radical polymerization (ATRP) and ring-opening metathesis polymerization (ROMP). The book also contains new content on the latest developments in polymer characterisation methods as well as applications of polymers including co-ordination polymers and lithium-polymer batteries. The book is essential reading for university students, teachers and scientists who wish to acquire an up-to-the-minute overview of polymer science and its many specialised topics in an informative and easy to read style.
AROMA PROFILE OF THYMUS VULGARIS L. GROWING WILD IN TURKEY (2004)

The establishment of aromatic profile of essential oil isolated by hydrodistillation of the overground parts of Thymus vulgaris was examined by a combination of GC and GC/MS. Identified were thirty components. They constituted approximately 100 % of the main elements of the essential oil, as follows: thymol (46.2%), γ-terpinene (14.1%), p-cymene (9.9%), lina- lool (4.0%), myrcene (3.5%), α- pinene (3.0%) and α-thujene (2.8%). The essential T.vulgaris characteristic was its high content of thymol (46.2%).
Scaling Graph-based Semi Supervised Learning to Large Number of Labels Using Count-Min Sketch (2013)

Graph-based Semi-supervised learning (SSL) algorithms have been successfully used in a large number of applications. These methods classify initially unlabeled nodes by propagating label information over the structure of graph starting from seed nodes. Graph-based SSL algorithms usually scale linearly with the number of distinct labels (m), and require O(m) space on each node. Unfortunately, there exist many applications of practical significance with very large m over large graphs, demanding better space and time complexity. In this paper, we propose MAD-Sketch, a novel graph-based SSL algorithm which compactly stores label distribution on each node using Count-min Sketch, a randomized data structure. We present theoretical analysis showing that under mild conditions, MAD-Sketch can reduce space complexity at each node from O(m) to O(log m), and achieve similar savings in time complexity as well. We support our analysis through experiments on multiple real world datasets. We observe that MAD-Sketch achieves similar performance as existing state-of-the-art graph-based SSL algorithms, while requiring smaller memory footprint and at the same time achieving up to 10x speedup. We find that MAD-Sketch is able to scale to datasets with one million labels, which is beyond the scope of existing graph-based SSL algorithms.
Self‐Healing Polyurethanes with Shape Recovery (2014)

Two new thermoresponsive self‐healing polyurethanes (1DA1T and 1.5DA1T) based on the Diels–Alder (DA) reaction between furan and maleimide moieties are developed that use the shape‐memory effect to bring crack faces into intimate contact such that healing can take place. Unlike other self‐healing polymers, these polymers do not require external forces to close cracks but rather they use the shape‐memory effect to autonomously close the crack. Both polyurethanes have a stable polymer structure and comparable mechanical properties to commercial epoxies. A differential scanning calorimeter is employed to check the glass transition temperature of the polymers as well as the DA and retro‐DA (rDA) reaction temperatures. These DA and rDA reactions are confirmed with variable‐temperature proton nuclear magnetic resonance. Healing efficiency is calculated using a measurement of the failure load from compact tension testing. The results show that the shape‐memory effect can replace external forces to close two crack surfaces and the DA reaction can be repeatedly employed to heal the cracks.
Diamond synthesis in oxygen-acetylene flames: Inhomogeneities and the effects of hydrogen addition (1991)

Micro-Raman spectroscopy, scanning electron microscopy and a surface density counting technique have been used to probe the inhomogeneities of diamond crystallites grown with an oxygen-acetylene flame on a scratched Si(100) surface. The surface temperature profile was measured using a thermal imaging camera and compared with the observed inhomogeneities in the diamond crystallites. It is concluded that the flame species flux to the surface is the dominant factor contributing to the diamond crystallite inhomogeneities. Hydrogen addition to the oxygen-acetylene flame was studied. The addition of hydrogen reduced the amount of ‘‘amorphous’’ carbon contained in the diamond crystallites as measured with Raman spectroscopy. Growth density profiles were determined as a function of the inner flame front to substrate distance. For uniform growth density in the oxygen-acetylene flame the substrate must be placed in the acetylene feather at a sufficient distance from the inner flame to avoid annular growth.
The Present and Future of Fractional Flow Reserve (2014)

Revascularization of coronary artery stenosis should be based on objective evidence of ischemia. Fractional flow reserve (FFR) is an invasive physiologic index that can be easily measured in the cardiac catheterization laboratory to assess the functional significance of coronary stenosis. FFR-guided revascularization strategy has been proven to be better than angiography-guided strategy in patients with coronary artery disease. Recent development of more convenient ways to induce hyperemia will reduce the barrier to measuring FFR and further expand its clinical applicability. Invasive physiologic indices without hyperemia are also under active investigation. Moreover, a novel noninvasive FFR measurement based on coronary CT angiography and computational fluid dynamics has been developed and will soon be incorporated into clinical practice. Given the rapid adoption of invasive and noninvasive physiologic indices in daily practice, a review of the current status of FFR and future perspectives is presented.
A low complexity impulse radio based UWB transceiver model for automated arrhythmia analysis (2008)

In this paper, a 4GHz clock synchronized transceiver model is proposed for the transmission of biomedical sensor signals like ECG to perform an automated diagnosis of arrhythmia. The system is based on non-coherent architecture which enables the receiver to be extremely simple and largely insensitive to the transmitted pulse shape. By using energy collection approach, a bank of integrators is used to determine the energy of the signal for specific intervals of time, thus making the receiver efficient in a multipath environment. Detection of arrhythmia requires an accurate estimation of the R-R interval of the ECG signal. The proposed model estimates R-R interval and detects different catastrophic arrhythmias.