gebhart/patrepeval huggingface dataset:
Framework-Catenation Isomerism in Metal−Organic Frameworks and Its Impact on Hydrogen Uptake (2007)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTFramework-Catenation Isomerism in Metal−Organic Frameworks and Its Impact on Hydrogen UptakeShengqian Ma, Daofeng Sun, Michael Ambrogio, Jacqueline A. Fillinger, Sean Parkin, and Hong-Cai ZhouView Author Information Department of Chemistry & Biochemistry, Miami University, Oxford, Ohio 45056, and Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506 Cite this: J. Am. Chem. Soc. 2007, 129, 7, 1858–1859Publication Date (Web):January 26, 2007Publication History Received17 October 2006Published online26 January 2007Published inissue 1 February 2007https://pubs.acs.org/doi/10.1021/ja067435shttps://doi.org/10.1021/ja067435srapid-communicationACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views9785Altmetric-Citations595LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (4)»Supporting Information Supporting Information SUBJECTS:Genetics,Hydrogen,Ligands,Metal organic frameworks,Molecular structure Get e-Alerts
Oxidative stress and heart failure (2011)

Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative to antioxidant defense, has been shown to play an important role in the pathophysiology of cardiac remodeling and heart failure (HF). It induces subtle changes in intracellular pathways, redox signaling, at lower levels, but causes cellular dysfunction and damage at higher levels. ROS are derived from several intracellular sources, including mitochondria, NAD(P)H oxidase, xanthine oxidase, and uncoupled nitric oxide synthase. The production of ROS is increased within the mitochondria from failing hearts, whereas normal antioxidant enzyme activities are preserved. Chronic increases in ROS production in the mitochondria lead to a catastrophic cycle of mitochondrial DNA (mtDNA) damage as well as functional decline, further ROS generation, and cellular injury. ROS directly impair contractile function by modifying proteins central to excitation-contraction coupling. Moreover, ROS activate a broad variety of hypertrophy signaling kinases and transcription factors and mediate apoptosis. They also stimulate cardiac fibroblast proliferation and activate the matrix metalloproteinases, leading to the extracellular matrix remodeling. These cellular events are involved in the development and progression of maladaptive myocardial remodeling and failure. Oxidative stress is also involved in the skeletal muscle dysfunction, which may be associated with exercise intolerance and insulin resistance in HF. Therefore, oxidative stress is involved in the pathophysiology of HF in the heart as well as in the skeletal muscle. A better understanding of these mechanisms may enable the development of novel and effective therapeutic strategies against HF.
HTS machines as enabling technology for all-electric airborne vehicles (2007)

Environmental protection has now become paramount as evidence mounts to support the thesis of human activity-driven global warming. A global reduction of the emissions of pollutants into the atmosphere is therefore needed and new technologies have to be considered. A large part of the emissions come from transportation vehicles, including cars, trucks and airplanes, due to the nature of their combustion-based propulsion systems. Our team has been working for several years on the development of high power density superconducting motors for aircraft propulsion and fuel cell based power systems for aircraft. This paper investigates the feasibility of all-electric aircraft based on currently available technology. Electric propulsion would require the development of high power density electric propulsion motors, generators, power management and distribution systems. The requirements in terms of weight and volume of these components cannot be achieved with conventional technologies; however, the use of superconductors associated with hydrogen-based power plants makes possible the design of a reasonably light power system and would therefore enable the development of all-electric aero-vehicles. A system sizing has been performed both for actuators and for primary propulsion. Many advantages would come from electrical propulsion such as better controllability of the propulsion, higher efficiency, higher availability and less maintenance needs. Superconducting machines may very well be the enabling technology for all-electric aircraft development.
Smelling Nano Aerial Vehicle for Gas Source Localization and Mapping (2019)

This paper describes the development and validation of the currently smallest aerial platform with olfaction capabilities. The developed Smelling Nano Aerial Vehicle (SNAV) is based on a lightweight commercial nano-quadcopter (27 g) equipped with a custom gas sensing board that can host up to two in situ metal oxide semiconductor (MOX) gas sensors. Due to its small form-factor, the SNAV is not a hazard for humans, enabling its use in public areas or inside buildings. It can autonomously carry out gas sensing missions of hazardous environments inaccessible to terrestrial robots and bigger drones, for example searching for victims and hazardous gas leaks inside pockets that form within the wreckage of collapsed buildings in the aftermath of an earthquake or explosion. The first contribution of this work is assessing the impact of the nano-propellers on the MOX sensor signals at different distances to a gas source. A second contribution is adapting the 'bout' detection algorithm, proposed by Schmuker et al. (2016) to extract specific features from the derivative of the MOX sensor response, for real-time operation. The third and main contribution is the experimental validation of the SNAV for gas source localization (GSL) and mapping in a large indoor environment (160 m²) with a gas source placed in challenging positions for the drone, for example hidden in the ceiling of the room or inside a power outlet box. Two GSL strategies are compared, one based on the instantaneous gas sensor response and the other one based on the bout frequency. From the measurements collected (in motion) along a predefined sweeping path we built (in less than 3 min) a 3D map of the gas distribution and identified the most likely source location. Using the bout frequency yielded on average a higher localization accuracy than using the instantaneous gas sensor response (1.38 m versus 2.05 m error), however accurate tuning of an additional parameter (the noise threshold) is required in the former case. The main conclusion of this paper is that a nano-drone has the potential to perform gas sensing tasks in complex environments.
Computing with spin qubits at the surface code error threshold (2021)

High-fidelity control of quantum bits is paramount for the reliable execution of quantum algorithms and for achieving fault-tolerance, the ability to correct errors faster than they occur. The central requirement for fault-tolerance is expressed in terms of an error threshold. Whereas the actual threshold depends on many details, a common target is the ~1% error threshold of the well-known surface code. Reaching two-qubit gate fidelities above 99% has been a long-standing major goal for semiconductor spin qubits. These qubits are well positioned for scaling as they can leverage advanced semiconductor technology. Here we report a spin-based quantum processor in silicon with single- and two-qubit gate fidelities all above 99.5%, extracted from gate set tomography. The average single-qubit gate fidelities remain above 99% when including crosstalk and idling errors on the neighboring qubit. Utilizing this high-fidelity gate set, we execute the demanding task of calculating molecular ground state energies using a variational quantum eigensolver algorithm. Now that the 99% barrier for the two-qubit gate fidelity has been surpassed, semiconductor qubits have gained credibility as a leading platform, not only for scaling but also for high-fidelity control.
Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen (2009)

In the present study, we identified that the ectopic ATPB in tumor cellular membrane was the non-small cell lung cancer (NSCLC) associated antigen. ATPB may be a potential biomarker and therapeutic target for the immunotherapy of NSCLC.
Building Solder Bumps on GaAs Flip Chip Schottky Devices (2003)

The semiconductor industry has made astonishing improvements in decreasing circuit dimensions and more importantly, greater performance. Making connections with gold contacts on GaAs devices using solder bumps instead of silver Epoxy offers lower contact resistance and hence, better performance. Further more, solder bump application to GaAs devices is amenable to high volume production and ease of manufacturing. Benefits from using solder bumps then become obvious for connections. This paper describes a process development using our existing technology of wafer processing in both wet and dry chemistries to build solder bumps on GaAs wafer for flip chip Schottky devices. Eutectic Sn/Pb solder bumps and Pb-free solder bumps were investigated. Detailed processing and chemistry will be discussed. Reliability of solder bumps on GaAs flip chip Schottky devices will also be presented.
Emission of Acoustic Waves from Polymers under Stress (1990)

A new rheo-photoacoustic Fourier transform infrared cell has been developed to perform stress-strain studies on polymeric materials. The rheo-photoacoustic measurements lead to the enhancement of the photoacoustic signal and allow one to monitor the effect of elongational forces on the molecular structure of polymers. Propagating acoustic waves are detected as a result of infrared reabsorption and the deformational and thermal property changes upon the applied stress.
Detecting alpha spindle events in EEG time series using adaptive autoregressive models (2013)

Modeling the alpha band EEG using discounted AR models provides an efficient method for detecting oscillatory alpha activity in EEG. The method is based on statistical principles and can generally be applied to detect rhythmic activity in any frequency band or brain region.
178-Nucleotide sequence surrounding the cos site of bacteriophage lambda DNA (1978)

A nucleotide sequence of 61 nucleotides at the left end and 117 nucleotides at the right end of DNA from bacteriophage lambdacI857Sam7 was determined by the Maxam and Gilbert method. A perfect inverted repeat sequence of 10 nucleotides is near the left end, and one of 15 nucleotides is near the right end. DNA from another closely related lambda strain, lambdacI857prm116Sam7, has about 10% divergence in the sequence of the first 110 nucleotides at the right end and has a 17-member perfect inverted repeat sequence.
Design and Analysis of Testable Mutual Exclusion Elements (2015)

Mutual exclusion elements (MUTEXes) are fundamental components of asynchronous arbiters and are particularly critical to ensure metastable signals are properly filtered before reaching the arbiter outputs. However, despite their importance, the testability of these circuits is typically limited to functional testing. This paper discusses why this is not sufficient and addresses testability issues in both full-custom and standard-cell implementations. In particular, it proposes two new testable implementations that not only ensure improved coverage for single stuck-at faults but also enable testing the filtering of metastable signals. Additionally, this article quantifies the cost of the testable designs by comparing them to similar traditional designs in terms of area, power and metastability resolution time. Results show the proposed optimizations do increase area and power but have small impact on performance.
Difficult and urgent open problems in document image analysis for libraries (2004)

Open problems in document image analysis research and development relevant to digital libraries (DLs) are briefly described and their difficulty and urgency estimated. They are grouped according to the stage of processing, in the construction of DLs, where they first apply: image capture, early processing, content extraction and recognition, structure analysis, retrieval, & presentation; and in personal and interactive DLs.
T232K/K238Q Aerolysin Nanopore for Mapping Adjacent Phosphorylation Sites of a Single Tau Peptide (2020)

Abstract Tau phosphorylation shows direct clinical importance as the hyperphosphorylation and aggregation of tau exists in a range of tauopathies. However, it is still challenging to study tau phosphorylation owing to its multiple and adjacent phosphorylation sites in the tau sequence. To address this challenge, here, a designed T232K/K238Q mutant aerolysin nanopore is introduced which synergistically incorporates the enhanced electrostatic interaction at T232K site and the high repelling barrier at K238Q site. The distinct current blockages produced by a T232K/K238Q aerolysin sensor achieve nearly 100% identification accuracy for the characteristic distribution of unphosphorylated tau peptide, pS262‐, pT263‐tau peptide, and pS262/pT263‐tau peptide. The excellent sensing ability of the T232K/K238Q nanopore originates from the extremely slow translocation speed which prolongs the duration up to tens or hundreds milliseconds for a nine‐amino‐acid peptide. It is envisioned that the design ideas of the T232K/K238Q aerolysin nanopore can be further applied to analyze other protein/peptide post‐translational modification as it provides the exquisite sensitivity for identifying the modification of single amino acids.
Mycological Studies of Lake Champlain (1970)

SUMMARYAnalyses of the seasonal fluctuation of yeast populations in Lake Champlain demonstrated a standing crop composed predominantly of Cryptococcus albidus, Rhodotorula spp., Torulopsis spp., yeasts of the Candida krusei-Pichia membranaefaciens complex and the omnipresent black yeast-like fungus Aureobasidium pullulans. Cell concentrations generally were less than 20 cells/100 ml, and varied between 1 to over 400/100 ml. In sectors of the Lake affected directly by industrial or urban effluents, distinctive yeast populations regularly exceeded 300 cells/100 ml. These yeasts rarely were isolated from other regions of the Lake. In areas receiving heated wood-pulp wastes, thermoduric strains capable of growth at 45 C were isolated. Comparison of data on yeast populations with that obtained in earlier studies of subtropical waters, demonstrates the feasibility of using species distribution patterns as indicators of water quality.
Computer Viruses and Related Threats to Computer and Network Integrity. (1989)

Abstract Computer viruses, worms, Trojan horses, and other exotic-sounding computer security have become a subject of considerable interest and concern in the computing and communications communities. This brief paper discusses the kinds of threats to security that such programs represent, and suggests some reasonable actions that computer and network users and owners can take to help minimize the risks. These threats are just beginning to be thoroughly studied, and this paper will by no means provide answers to all the problems they present. It is intended only to make the reader aware of the most essential definitions and issues, and to provide some references to further reading.
Cholera toxin as a mucosal adjuvant: effects of H-2 major histocompatibility complex and lps genes (1992)

In previous studies we found that cholera toxin (CT) can act as a mucosal adjuvant; i.e., it can stimulate an intestinal secretory immunoglobulin A (S-IgA) response to an unrelated protein antigen when both are fed together to mice. The purpose of this study was to determine whether the mucosal adjuvanticity of CT is restricted by either H-2 major histocompatibility complex or lps genes by using congenic inbred strains that differ at only a single genetic locus. Groups of five mice each were fed saline, CT (10 micrograms), keyhole limpet hemocyanin (KLH) (5 mg), or both CT and KLH on four different days, and samples of intestinal secretions and plasma were obtained 1 week after the last feeding. In the mice fed both CT and KLH, the intestinal S-IgA anti-KLH response was higher in H-2b congenic strains than in H-2k congenic strains, and in addition there was a highly significant positive correlation between the intestinal S-IgA anti-KLH and S-IgA anti-CT responses in the intestinal secretions of individual mice. Similarly, in the lps congenic strains, mice of the endotoxin-responsive strain that were fed both CT and KLH had substantially higher S-IgA and plasma IgG responses to KLH than did mice of the endotoxin-unresponsive strain. The effect of CT on the induction of oral tolerance to KLH in the H-2 congenic strains was also examined. In contrast to the results above, the abrogation of oral tolerance to KLH by CT occurred in all strains regardless of H-2 haplotype. Similarly, the adjuvant effect of CT on plasma IgG anti-KLH responses after both were given together intraperitoneally was not restricted by H-2. I conclude that the mucosal adjuvanticity of CT is influenced by both the H-2 and lps genetic loci and that it appears to depend on a vigorous mucosal immune response to CT itself.
Drill Bit Noise Illuminates the San Andreas Fault (2008)

Extracting the vibration response of the subsurface from noise is a rapidly growing field of research [ Curtis et al. , 2006; Larose et al. , 2006]. We carried out broadside imaging of the San Andreas fault zone (SAFZ) using drill bit noise created in the main hole of the San Andreas Fault Observatory at Depth (SAFOD), near Parkfield, Calif. Imaging with drill bit noise is not new, but it traditionally requires the measurement of the vibrations of the drill stem [ Rector and Marion , 1991]; such measurements provide the waves radiated by the drill bit. At SAFOD, these measurements were not available due to the absence of an accelerometer mounted on the drill stem. For this reason, the new technique of deconvolution interferometry was used [ Vasconcelos and Snieder , 2008]. This technique extracts the waves propagating between seismometers from recordings of incoherent noise.
Immunotherapy for Prostate Cancer Enters Its Golden Age (2012)

In the United States, prostate cancer is the most frequent malignancy in men and ranks second in terms of mortality. Although recurrent or metastatic disease can be managed initially with androgen ablation, most patients eventually develop castration-resistant disease within a number of years, for which conventional treatments (eg, chemotherapy) provide only modest benefits. In the last few years, immunotherapy has emerged as an exciting therapeutic modality for advanced prostate cancer, and this field is evolving rapidly. Encouragingly, the US Food and Drug Administration (FDA) has recently approved two novel immunotherapy agents for patients with advanced cancer: the antigen presenting cell-based product sipuleucel-T and the anti-CTLA4 (cytotoxic T-lymphocyte antigen 4) antibody ipilimumab, based on improvements in overall survival in patients with castration-resistant prostate cancer and metastatic melanoma, respectively. Currently, a number of trials are investigating the role of various immunological approaches for the treatment of prostate cancer, many of them with early indications of success. As immunotherapy for prostate cancer enters its golden age, the challenge of the future will be to design rational combinations of immunotherapy agents with each other or with other standard prostate cancer treatments in an effort to improve patient outcomes further.
An experimental study of reliable wireless communications in vehicles (2016)

Recent works on enhancing comfortability and convenience in vehicles reveal that information collections by various wireless sensor nodes have the potential due to their easiness of install and their small size. However, the conventional wireless network standards achieve insufficient reliability for practical in-vehicle communications. In this paper, through implementing 2.4GHz devices in an actual vehicle with crews in the cabin. Based on the results, we propose a method to provide reliable multi-hop communications in a vehicle using overhearing. In the proposed method, the neighbor nodes overhear a packet sent from a source node. If the destination node does not receive the packet, neighbor nodes send the overheard packet as proxies of the source node. We evaluate the performance of the proposed method by computer simulation and experimental implementation. One of the results shows that the proposed method achieves 99.9% packet arrival ratio within 20ms.
Liver transplantation for fulminant hepatic failure: North american experience (1995)

s an indication for transplantation, fulminant A hepatic failure (FHF) accounts for approximately 7% of the liver transplantations currently performed in the United States and This percentage is very small in comparison with the number of transplants performed for chronic liver disease, but FHF dominates over other indications in terms of urgency, difficult decision-making, and the use of innovative approaches. The propensity for either precipitous deterioration or dramatic improvement in the condition of patients with this syndrome requires intensive patient monitoring and hour-byhour re-evaluation of their candidacy for transplantation. The major challenges facing clinicians are selecting in a timely fashion those patients who are not going to survive without a transplant and supporting them until a donor organ is found, which may take several days. The issues include candidacy, timing, and outcome.
Scintillation Analysis of Gamma Radiation with Crystals of Bismuth Germanate. (1982)

This report provides an introduction to the theory of scintillation counting and analysis of nuclear radiation, with particular attention to an application for bismuth germanate (Bi4Ge3O12), or BGO, scintillator crystals. Radiation damage experiments using 100 MeV electrons from a linear accelerator were conducted to evaluate the induced radiation and subsequent resolution capability of bismuth germanate and thallium activated sodium iodide scintillators. It was shown that BGO has a much higher resistance to radiation damage from electron and photon activation sources.