gebhart/patrepeval huggingface dataset:
Immunomodulatory Effects of Ambroxol on Airway Hyperresponsiveness and Inflammation (2016)

Ambroxol is used in COPD and asthma to increase mucociliary clearance and regulate surfactant levels, perhaps through anti-oxidant and anti-inflammatory activities. To determine the role and effect of ambroxol in an experimental model of asthma, BALB/c mice were sensitized to ovalbumin (OVA) followed by 3 days of challenge. Airway hyperresponsiveness (AHR), lung cell composition and histology, and cytokine and protein carbonyl levels in bronchoalveolar lavage (BAL) fluid were determined. Ambroxol was administered either before the first OVA challenge or was begun after the last allergen challenge. Cytokine production levels from lung mononuclear cells (Lung MNCs) or alveolar macrophages (AM) were also determined. Administration of ambroxol prior to challenge suppressed AHR, airway eosinophilia, goblet cell metaplasia, and reduced inflammation in subepithelial regions. When given after challenge, AHR was suppressed but without effects on eosinophil numbers. Levels of IL-5 and IL-13 in BAL fluid were decreased when the drug was given prior to challenge; when given after challenge, increased levels of IL-10 and IL-12 were detected. Decreased levels of protein carbonyls were detected in BAL fluid following ambroxol treatment after challenge. In vitro, ambroxol increased levels of IL-10, IFN-γ, and IL-12 from Lung MNCs and AM, whereas IL-4, IL-5, and IL-13 production was not altered. Taken together, ambroxol was effective in preventing AHR and airway inflammation through upregulation of Th1 cytokines and protection from oxidative stress in the airways.
Neuere Entwicklungen auf dem Gebiet der Raffination der Speiseöle (1986)

Abstract Die Voraussetzungen der physikalischen Raffination von Speiseölen werden durchleuchtet. Eine Hauptvoraussetzung ist die weitgehende Entfernung von Phospholipiden, Lipoproteinen, freien und gebundenen Kohlehydraten, Schwermetallspuren und organischen Farbstoffen. Mit diesem Hintergrund werden saure Entschleimungsverfahren wie Super‐Degumming, Special‐Degumming sowie das Alcon‐Verfahren auf ihren Mechanismus und Wirksamkeit untersucht. Darüber hinaus wird das Verfahren der Ultrafiltration von Speiseölmiscella als eine neue Raffinationsmethode vorgestellt, die die Voraussetzungen der physikalischen Raffination sehr gut erfüllt. Dieses Verfahren nutzt das Prinzip der Umkehrosmose aus und trennt die Phospholipide und zahlreiche andere, in Rohmiscella vorkommende Verunreinigungen des Öles in einem einzigen Verfahrensschritt ab. Das Prinzip dieses Verfahrens und die Variationsmöglichkeiten dieses Verfahrens werden erläutert.
Hypoxia and podocyte-specific<i>Vhlh</i>deletion confer risk of glomerular disease (2007)

Hypoxia is a potent regulator of a multitude of cellular processes, including metabolism and cell survival. The transcriptional response to oxygen deprivation is mainly mediated by hypoxia-inducible factors (HIFs), which are targeted for proteasomal degradation by the von Hippel-Lindau tumor suppressor protein (pVHL) under normoxia. Podocytes, as part of the glomerular filtration barrier, are prone to hypoxic injury during diseases affecting the glomerulus. VHL and HIF1 were functional in mature murine podocytes in vivo and in vitro, with HIF1 protein stabilization and target gene transcription under both hypoxia and VHL deficiency. Podocyte-specific Vhlh gene loss, mimicking podocyte hypoxia, in young mice of mixed background led to glomerulomegaly and occasional glomerulosclerosis, despite preserved glomerular development. In parallel, hypoxia effects on podocytes in cell culture included increased susceptibility to apoptosis, associated with nuclear translocation of apoptosis-inducing factor (AIF). Similarly, Vhlh gene inactivation in podocytes in vitro resulted in a significant survival disadvantage, particularly in conjunction with additional proapoptotic stimuli. Evaluation of the global transcriptional response to hypoxia in podocytes by microarray analysis revealed a typical upregulation of HIF target genes as well as the induction of genes relevant for stress response, cell-cell, and cell-extracellular matrix interaction. While the lack of a prominent phenotype in young mice with VHL-deficient podocytes is consistent with the absence of specific glomerular manifestations in human VHL disease, a low-oxygen environment of podocytes may contribute to the progression of glomerular disease by altering cellular metabolism and survival.
Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles (2020)

Oligonucleotide therapeutics hold promise for the treatment of muscle- and heart-related diseases. However, oligonucleotide delivery across the continuous endothelium of muscle tissue is challenging. Here, we demonstrate that docosanoic acid (DCA) conjugation of small interfering RNAs (siRNAs) enables efficient (~5% of injected dose), sustainable (>1 month), and non-toxic (no cytokine induction at 100 mg/kg) gene silencing in both skeletal and cardiac muscles after systemic injection. When designed to target myostatin (muscle growth regulation gene), siRNAs induced ~55% silencing in various muscle tissues and 80% silencing in heart, translating into a ~50% increase in muscle volume within 1 week. Our study identifies compounds for RNAi-based modulation of gene expression in skeletal and cardiac muscles, paving the way for both functional genomics studies and therapeutic gene modulation in muscle and heart.
Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes. (1994)

We examined whether apoptosis occurs in cardiomyocytes by hypoxia in vitro. Neonatal rat cardiomyocytes and nonmyocytes were cultured in 95% N2-5% CO2 atmosphere to produce hypoxic conditions. DNA fragmentation into integer multiples of the internucleosomal DNA length was observed in cardiomyocytes as early as 12 hours, whereas nonmyocytes did not show fragmentation of DNA up to 72 hours. DNA fragmentation of cardiomyocytes induced by hypoxia was also confirmed by nick-end labeling in situ. Messenger RNA for Fas antigen, a mediator of apoptotic cell death, was expressed in both cardiomyocytes and nonmyocytes as revealed by Northern blotting and in situ hybridization. In hypoxic condition, Fas messenger RNA levels in cardiomyocytes were upregulated by twofold over controls, whereas those of nonmyocytes were downregulated. These results indicate that cardiomyocyte death by hypoxia can occur via apoptosis and that Fas antigen may be associated with the mechanism of this apoptotic process.
Circularly polarised antenna arrays (1989)

This chapter is concerned with various techniques for circularly polarised microstrip arrays. Circular polarisation is effective for many radio systems, such as communications, remote sensing, navigation and radar systems. In particular, at present, mobile-satellite-communication and direct-broadcasting satellite systems use circular polarisation, because they do not need polarisation tracking.
Thickness measurements with electron energy loss spectroscopy (2008)

Measurements of thickness using electron energy loss spectroscopy (EELS) are revised. Absolute thickness values can be quickly and accurately determined with the Kramers-Kronig sum method. The EELS data analysis is even much easier with the log-ratio method, however, absolute calibration of this method requires knowledge of the mean free path of inelastic electron scattering lambda. The latter has been measured here in a wide range of solids and a scaling law lambda approximately rho(-0.3) versus mass density rho has been revealed. EELS measurements critically depend on the excitation and collection angles. This dependence has been studied experimentally and theoretically and an efficient model has been formulated.
Acorns: A Framework for Accelerating Deep Neural Networks with Input Sparsity (2019)

Deep neural networks have been employed in a broad range of applications, including face detection, natural language processing, and autonomous driving. Yet, the neural networks with the capability to tackle real-world problems are intrinsically expensive in computation, hindering the usage of these models. Sparsity in the input data of neural networks provides an optimizing opportunity. However, harnessing the potential performance improvement on modern CPU faces challenges raised by sparse computations of the neural network, such as cache-unfriendly memory accesses and efficient sparse kernel implementation. In this paper, we propose Acorns, a framework to accelerate deep neural networks with input sparsity. In Acorns, sparse input data is organized into our designed sparse data layout, which allows memory-friendly access for kernels in neural networks and opens the door for many performance-critical optimizations. Upon that, Acorns generates efficient sparse kernels for operators in neural networks from kernel templates, which combine directions that express specific optimizing transformations to be performed, and straightforward code that describes the computation. Comprehensive evaluations demonstrate Acorns can outperform state-of-the-art baselines by significant speedups. On the real-world detection task in autonomous driving, Acorns demonstrates 1.8-22.6× performance improvement over baselines. Specifically, the generated programs achieve 1.8-2.4× speedups over Intel MKL-DNN, 3.0-8.8× speedups over TensorFlow, and 11.1-13.2× speedups over Intel MKL-Sparse.
Drawing the red line in Java (2003)

Software-based protection has become a viable alternative to hardware-based protection in systems based on languages such as Java, but the absence of hardware mechanisms for protection has been coupled with an absence of a user/kernel boundary. We show why such a "red line" must be present in order for a Java virtual machine to be as effective and as reliable as an operating system. We discuss how the red line can be implemented using software mechanisms, and explain the ones we use in the Java system that we are building.
CMOS and Beyond (2014)

Get up to speed with the future of logic switch design with this indispensable overview of the most promising successors to modern CMOS transistors. Learn how to overcome existing design challenges using novel device concepts, presented using an in-depth, accessible, tutorial-style approach. Drawing on the expertise of leading researchers from both industry and academia, and including insightful contributions from the developers of many of these alternative logic devices, new concepts are introduced and discussed from a range of different viewpoints, covering all the necessary theoretical background and developmental context. Covering cutting-edge developments with the potential to overcome existing limitations on transistor performance, such as tunneling field-effect transistors (TFETs), alternative charge-based devices, spin-based devices, and more exotic approaches, this is essential reading for academic researchers, professional engineers, and graduate students working with semiconductor devices and technology.
Pharmacokinetics and red cell utilization of <sup>52</sup>Fe/<sup>59</sup>Fe‐labelled iron polymaltose in anaemic patients using positron emission tomography (2003)

Parenteral iron-polysaccharide complexes are increasingly applied. The pharmacokinetics of iron sucrose have been assessed by our group using positron emission tomography (PET). A single intravenous injection of 100 mg iron as iron (III) hydroxide-polymaltose complex, labelled with a tracer in the form of 52Fe/59Fe, was similarly assessed in six patients using PET for about 8 h. Red cell utilization was followed for 4 weeks. Iron polymaltose was similarly distributed to the liver, spleen and bone marrow. However, a larger proportion of this complex was rapidly distributed to the bone marrow. The shorter equilibration phase for the liver, about 25 min, indicates the minimal role of the liver for direct distribution. Splenic uptake also reflected the reticuloendothelial handling of this complex. Red cell utilization ranged from 61% to 99%. Despite the relatively higher uptake by the bone marrow, there was no saturation of marrow transport systems at this dose level. In conclusion, high red cell utilization of iron polymaltose occurred in anaemic patients. The major portion of the injected dose was rapidly distributed to the bone marrow. In addition, the reticuloendothelial uptake of this complex may reflect the safety of polysaccharide complexes. Non-saturation of transport systems to the bone marrow indicated the presence of a large interstitial transport pool, which might possibly be transferrin.
An evaluation method for Business Process Management products (2009)

Business Process Management (BPM) is a management discipline aimed at describing and managing the business processes in an organization. The goal of Business Process Management is to achieve the organization‟s objectives by aligning the business processes with these objectives and to continually improve these processes. Even though there are many vendors that supply BPM products, there is no scientific method available today to evaluate these products and to compare them. This thesis proposes an evaluation method for Business Process Management products. This method was developed by creating a framework on BPM by analyzing the state of the literature regarding BPM. This framework contains literature and criteria that have been extracted from this literature
Spectroscopic and Electrochemical Studies of U(IV)−Hexachloro Complexes in Hydrophobic Room-Temperature Ionic Liquids [BuMeIm][Tf<sub>2</sub>N] and [MeBu<sub>3</sub>N][Tf<sub>2</sub>N] (2005)

The behavior of U(IV) octahedral complexes [cation]2[UCl6], where the [cation]+ is [BuMeIm]+ and [MeBu3N]+, is studied using UV/visible spectroscopy, cyclic staircase voltammetry, and rotating disk electrode voltammetry in hydrophobic room-temperature ionic liquids (RTILs) [BuMeIm][Tf2N] and [MeBu3N][Tf2N], where BuMeIm+ and MeBu3N+ are 1-butyl-3-methylimidazolium and tri-n-butylmethylammonium cations, respectively, and Tf2N- is the bis(trifluoromethylsulfonyl)imide anion. The absorption spectra of [cation]2[UCl6] complexes in the RTIL solutions are similar to the diffuse solid-state reflectance spectra of the corresponding solid species, indicating that the octahedral complex UCl6(2-) is the predominant chemical form of U(IV) in Tf2N--based hydrophobic ionic liquids. Hexachloro complexes of U(IV) are stable to hydrolysis in the studied RTILs. Voltammograms of UCl(6)2- at the glassy carbon electrode in both RTILs and at the potential range of -2.5 to +1.0 V versus Ag/Ag(I) reveal the following electrochemical couples: UCl6-/UCl6(2-) (quasi-reversible system), UCl(6)2-/UCl6(3-) (quasi-reversible system), and UCl(6)2-/UCl6(Tf2N)x-3+x (irreversible reduction). The voltammetric half-wave potential, Ep/2, of the U(V)/U(IV) couple in [BuMeIm][Tf2N] is positively shifted by 80 mV compared with that in [MeBu3N][Tf2N]. The positive shift in the Ep/2 value for the quasi-reversible U(IV)/U(III) couple is much greater (250 mV) in [BuMeIm][Tf2N]. Presumably, the potential shift is due to the specific interaction of BuMeIm+ with the uranium-hexachloro complex in ionic liquid. Scanning the negative potential to -3.5 V in [MeBu3N][Tf2N] solutions of UCl6(2-) reveals the presence of an irreversible cathodic process at the peak potential equal to -3.12 V (at 100 mV/s and 60 degrees C), which could be attributed to the reduction of U(III) to U(0).
UhpT, the sugar phosphate antiporter of Escherichia coli, functions as a monomer. (1990)

We have characterized the minimal functioning unit of UhpT, the secondary carrier that mediates exchange of phosphate and glucose 6-phosphate in Escherichia coli. Membranes of a UhpT overproducing strain were solubilized with 1.25% octyl beta-D-glucopyranoside, in the presence of 0.1% E. coli phospholipid and with 20% glycerol as the osmolyte stabilant. That soluble UhpT could bind its natural substrates was indicated by the protections afforded by sugar phosphates against thermal inactivation or chemical modification with pyridoxal 5'-phosphate. Moreover, the degree of protection correlated with the strength of interaction between UhpT and the test substrate (2-deoxyglucose 6-phosphate = glucose 6-phosphate greater than galactose 6-phosphate = glucose 1-phosphate much greater than glucose 6-sulfate). Other experiments demonstrated that soluble UhpT existed as a monomer. For example, during both high performance liquid chromatography and conventional gel permeation chromatography, the elution pattern of UhpT activity was measured directly by a rapid reconstitution technique. In both cases, and in the presence and absence of substrate, UhpT activity traveled as a single component of Mr 53,000, corresponding closely to the sequence prediction of 50,600. Finally, reconstitution was studied at protein to lipid ratios low enough to achieve between 0.075 and 1.5 UhpT monomers/proteoliposome. Specific activity was constant throughout this range, a finding consistent with the idea of a functional monomer. Mitochondria and chloroplasts provide the only other anion exchange carriers described at this level of biochemical resolution, and these organelle antiporters function as dimers. By contrast, work summarized here places their bacterial counterpart, UhpT, in the same class as the lactose carrier of E. coli and the glucose carrier of the human erythrocyte, both of which function as monomers. Consideration of this pattern in conjunction with the known hydropathy profiles of these proteins suggests a novel scheme for the classification of all secondary carriers, with implications for both the structure and origin of these transport proteins.
Design of two architectures of asynchronous binary neural networks using linear programming (1990)

A novel design technique for asynchronous binary neural networks is proposed. This design uses linear programming to design two architectures: (i) a fully connected network that reads a N-digit cue and classifies it into a category represented by a N-digit pattern: and (ii) a two-layer network (with lateral connections) that has M neurons in the first layer and L neurons in the second layer; the network reads an M-digit cue to the first layer and associates it with a second-layer L-digit pattern. In both cases, the objective function is a weighted sum of the number of errors that can be corrected by the network. A cue with this number of errors (or fewer) is guaranteed to converge to the correct pattern. An economical VLSI realization of the designed networks can be easily accomplished.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105 (2007)

As all immune responses have potential for damaging the host, tight regulation of such responses--in amplitude, space, time and character--is essential for maintaining health and homeostasis. It was thus inevitable that the initial wave of papers on the role of Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs) in activating innate and adaptive immune responses would be followed by a second wave of reports focusing on the mechanisms responsible for restraining and modulating signaling by these receptors. This overview outlines current knowledge and controversies about the immunobiology of the RP105/MD-1 complex, a modulator of the most robustly signaling TLR, TLR4.
THE USE OF PLATINUM OXIDE AS A CATALYST IN THE REDUCTION OF ORGANIC COMPOUNDS. IV. REDUCTION OF FURFURAL AND ITS DERIVATIVES<sup>1</sup> (1923)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE USE OF PLATINUM OXIDE AS A CATALYST IN THE REDUCTION OF ORGANIC COMPOUNDS. IV. REDUCTION OF FURFURAL AND ITS DERIVATIVES1W. E. Kaufmann and Roger AdamsCite this: J. Am. Chem. Soc. 1923, 45, 12, 3029–3044Publication Date (Print):December 1, 1923Publication History Published online1 May 2002Published inissue 1 December 1923https://pubs.acs.org/doi/10.1021/ja01665a033https://doi.org/10.1021/ja01665a033research-articleACS PublicationsRequest reuse permissionsArticle Views793Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Qualitative Political Communication| To Implement or Not to Implement? Participatory Online Communication in Swiss Cities (2015)

Social media platforms and other digital interactive media hold great potential for political communication. This study explores perceptions about this potential and the motivations to adopt participatory tools and assesses both motivations and challenges that local administrations face in the process of technology adoption for political communication. Switzerland is a critical case for local communication, because, on the one hand, media structures, media usage patterns, political culture, and legal regulations make it likely to find high levels of participatory online communication. On the other hand, the formalized participation opportunities of direct democracy may undermine the potential of online participation. Our analysis, based on interviews and document analysis, addresses the implementation of participatory online communication from the theoretical perspectives of rational choice and neoinstitutionalism. We found diffuse rather than specific motivations, role conflicts, frictions between informal online participation and formal decision-making processes, and low demand and resonance from citizens to be important challenges to the implementation of online participation.
Disruption of hepatocellular tight junctions by vascular endothelial growth factor (VEGF): a novel mechanism for tumor invasion (2004)

VEGF induces disruption of tight junctions in a PKC-alpha dependent manner. In addition to its known angioneogenic properties, VEGF may promote HCC spreading into normal liver parenchyma. The data may provide another rationale for the use of VEGF antagonists for tumor therapy.
GENETICS OF SESAME (1947)

Journal Article GENETICS OF SESAME Get access D. G. LANGHAM D. G. LANGHAM Biological Laboratories, Harvard University Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 38, Issue 11, November 1947, Pages 347–352, https://doi.org/10.1093/oxfordjournals.jhered.a105670 Published: 01 November 1947
Gadolinium-based Contrast Agent Accumulates in the Brain Even in Subjects without Severe Renal Dysfunction: Evaluation of Autopsy Brain Specimens with Inductively Coupled Plasma Mass Spectroscopy (2015)

Even in subjects without severe renal dysfunction, GBCA administration causes gadolinium accumulation in the brain, especially in the DN and GP.