gebhart/patrepeval huggingface dataset:
Genome-wide analysis of PDX1 target genes in human pancreatic progenitors (2018)

Our data provide stage-specific target genes of PDX1 during in vitro differentiation of stem cells into pancreatic progenitors that could be useful to identify pathways and molecular targets that predispose for diabetes. In addition, we show that T2DM-associated SNPs are enriched in active chromatin regions at the pancreatic progenitor stage, suggesting that the susceptibility to T2DM might originate from imperfect execution of a β-cell developmental program.
증례 : 신장이식 후 발생한 루푸스양 증후군 1예 (2010)

Systemic erythematous lupus is a systemic inflammatory autoimmune disease that develops from drug, viral, or chemical irritants. We report a case of lupus-like syndrome after kidney transplantation with an unknown cause. A 55-year-old woman was admitted with severe myalgia, fever, and arthralgia 2 days previously. She had received a kidney transplantation 8 years ago, because an acute kidney injury had progressed to chronic kidney disease. After transplantation, she had no problems. We performed blood, urine, and sputum cultures but could found no microorganisms. We suspected a connective tissue disease, such as adult Still`s disease, and performed autoantibody testing. As a result, antinuclear antibody was positive, and we diagnosed her with lupus-like syndrome due to an unknown cause. We increased the prednisolone dose and her symptoms improved.
A Genetic Algorithm-Based Level Set Curve Evolution for Prostate Segmentation on Pelvic CT and MRI Images (2010)

A novel genetic algorithm (GA) is presented here that performs level set curve evolution using texture and shape information to automatically segment the prostate on pelvic images in computed tomography and magnetic resonance imaging modalities. Here, the segmenting contour is represented as a level set function. The contours in a typical level set evolution are deformed by minimizing an energy function using the gradient descent method. In these methods, the computational complexity of computing derivatives increases as the number of terms (needed for curve evolution) in the energy function increase. In contrast, a genetic algorithm optimizes the level-set function without the need to compute derivatives, thereby making the introduction of new curve evolution terms straightforward. The GA developed here uses the texture of the prostate gland and its shape derived from manual segmentations to perform curve evolution. Using these high-level features makes automatic segmentation possible.
A rotation, scale and translation resilient public watermark (1999)

Summary form only given. Watermarking algorithms that are robust to the common geometric transformations of rotation, scale and translation (RST) have been reported for cases in which the original unwatermarked content is available at the detector so as to allow the transformations to be inverted. However, for public watermarks the problem is significantly more difficult since there is no original content to register with. Two classes of solution have been proposed. The first embeds a registration pattern into the content while the second seeks to apply detection methods that are invariant to these geometric transformations. This paper describes a public watermarking method which is invariant (or bares a simple relation) to the common geometric transforms of rotation, scale, and translation. It is based on the Fourier-Mellin transform which has previously been suggested. We extend this work, using a variation based on the Radon transform. The watermark is inserted into a projection of the image. The properties of this projection are such that RST transforms produce simple or no effects on the projection waveform. When a watermark is inserted into a projection, the signal must eventually be back projected to the original image dimensions. This is a one to many mapping that allows for considerable flexibility in the watermark insertion process. We highlight some theoretical and practical issues that affect the implementation of an RST invariant watermark. Finally, we describe preliminary experimental results.
Rapid, simple method for typing isolates of Mycobacterium tuberculosis by using the polymerase chain reaction (1993)

To develop a molecular typing method for Mycobacterium tuberculosis based on the polymerase chain reaction, oligonucleotide primers were designed to the ends of the insertion sequence IS6110 in an attempt to amplify DNA between clusters of this element on the genome. Although in many strains the copy number of this element is low and is distributed throughout the genome, most strains examined produced a banding pattern which varied between isolates including strains with one copy of IS6110. With strains isolated from patients in epidemiologic clusters of tuberculosis, the banding patterns were similar within each cluster but distinct from those in strains from different clusters. Similarly, multiple isolates from the same patient yielded a consistent banding pattern. Sequencing of four polymerase chain reaction products revealed that amplification was occurring between copies of IS6110 in two of the products and from a single copy of IS6110 to a nonspecific priming site in the other two. This technique provides a rapid and simple means of typing M. tuberculosis isolates for epidemiologic studies.
G<sub>1</sub> Cyclin Degradation: the PEST Motif of Yeast Cln2 Is Necessary, but Not Sufficient, for Rapid Protein Turnover (1994)

The 545-residue Cln2 protein, like the other G1 cyclins of Saccharomyces cerevisiae, is a very unstable protein. This instability is thought to play a critical role in regulating cell cycle progression. The carboxyl-terminal domains of Cln2 and the other G1 cyclins contain sequences rich in Pro, Glu (and Asp), Ser, and Thr (so-called PEST motifs) that have been postulated to make up the signals that are responsible for the rapid degradation of these and other unstable proteins. To test this hypothesis, the carboxyl-terminal 178 residues of Cln2 were fused to the C terminus of a reporter enzyme, a truncated form of human thymidine kinase (hTK delta 40). The resulting chimeric protein (hTK delta 40-Cln2) retained thymidine kinase activity but was markedly less stable than hTK, hTK delta 40, or an hTK-beta-galactosidase fusion protein, as judged by enzyme assay, immunoblotting with anti-hTK antibodies, pulse-chase analysis of the radiolabeled polypeptides, and ability to support the growth of a thymidylate auxotroph (cdc21 mutant) on thymidine-containing medium. Thus, the presence of the Cln2 PEST domain was sufficient to destabilize a heterologous protein. Furthermore, the half-life of hTK delta 40-Cln2 was similar to that of authentic Cln2, and the rate of degradation of neither protein was detectably enhanced by treatments known to cause G1 arrest, including exposure of MATa haploids to alpha-factor mating pheromone and shifting cdc28ts and cdc34ts mutants to the restrictive temperature. These results suggest that the major signals responsible for Cln2 instability are confined to its C-terminal third. Because hTK delta 40-Cln2 and Cln2 were expressed from heterologous promoters yet their half-lives both in asynchronous cultures and when arrested at various cell cycle stages were always similar, the Cln2 PEST domain contains a signal for rapid protein turnover that is constitutively active and operative throughout the cell cycle. Removal of the 37 codons that encode the most prominent PEST-like segment from either hTK delta 40-Cln2 or Cln2 decreased the turnover rate of the resulting proteins, as expected; however, an hTK delta 40 chimera containing only this 37-residue segment was not detectably destabilized, suggesting that this PEST sequence, when removed from its normal context, is not a self-contained determinant of protein instability.
Retinoids, Retinoic Acid Receptors, and Cancer (2011)

Retinoids (i.e., vitamin A, all-trans retinoic acid, and related signaling molecules) induce the differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but not all of the effects of retinoids. Retinoid signaling is often compromised early in carcinogenesis, which suggests that a reduction in retinoid signaling may be required for tumor development. Retinoids interact with other signaling pathways, including estrogen signaling in breast cancer. Retinoids are used to treat cancer, in part because of their ability to induce differentiation and arrest proliferation. Delivery of retinoids to patients is challenging because of the rapid metabolism of some retinoids and because epigenetic changes can render cells retinoid resistant. Successful cancer therapy with retinoids is likely to require combination therapy with drugs that regulate the epigenome, such as DNA methyltransferase and histone deacetylase inhibitors, as well as classical chemotherapeutic agents. Thus, retinoid research benefits both cancer prevention and cancer treatment.
The Identification of Blue Diffusion-Treated Sapphires (1990)

Blue diffusion-treated sapphires are becoming more prevalent than ever before. The diffusion technique, which involves the addition of color-causing chemicnls during heat trentment, results in a thin layer of color at the surface of colorless or light-colored sapphire. The color was found to be stable to routine cleaning procedures; however, it may be partially or completely-removed if the stone is repolished pf, recut. Recently, significant quantities o f so-called "deep" diffusiontreated sapphires have entered the market. This article documents the properties of these and other blue diffusion-treated sapphires, and presents means o f identifying this method using simple gemological tests.
Plasma endogenous sodium pump inhibitor in essential hypertension. (1983)

The presence of circulating Na+ pump inhibitors was investigated in hypertensive subjects using inhibition of ouabain binding to the pump and of Na+, K+-ATPase activity as tests. Plasma extracts from nearly half the normotensive subjects who were offspring of hypertensive parents as well as the essential hypertensive subjects were potent inhibitors. Three fractions, extracted from plasma, exhibited ouabain-like properties concerning competition for binding, inhibition of the Na+, K+-ATPase and of Na+-dependent serotonin uptake by platelets. When injected intracerebroventricularly, one of these fractions also induces a rise in blood pressure, as does ouabain. These results demonstrate the presence in some plasma of digitalis-like substances.
A MEMS variable Faraday cage as tuning element for integrated silicon micromachined cavity resonators (2010)

This paper reports the design and the realization of a variable-sized MEMS-based Faraday cage, used to tune the resonant frequency of a silicon micromachined cavity resonator. The Faraday cage is defined by a 2D-array of electrostatically controllable metal cantilevers. The cantilever array effectively shields an enclosed (air) volume (forming the Faraday cage) located inside the micromachined cavity resonator. The Faraday cage perturbs the electromagnetic field distribution inside the cavity resonator and provides a means to electrically tune the resonant frequency of the resonator. In this realization, the cavity resonator was micromachined using bulk KOH etching in silicon and assembled in a low temperature die-to-wafer soldering process. The electrical feeding was realized in thin-film metallizations and the resonator is formed as a two-chip assembly. We measured a maximal frequency tuning of 1.2 GHz at 60 GHz with a tuning voltage of 16 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DC</sub> .
KLRG1 Negatively Regulates Natural Killer Cell Functions through the Akt Pathway in Individuals with Chronic Hepatitis C Virus Infection (2013)

In this study, we demonstrate that killer cell lectin-like receptor subfamily G member 1 (KLRG1), a transmembrane protein preferentially expressed on T cells, is highly expressed on CD56(+) NK cells, which are significantly reduced in their numbers and functions in the peripheral blood of patients with chronic hepatitis C virus (HCV) infection compared to subjects without infection. KLRG1 expression is also upregulated on healthy NK cells exposed to Huh-7 hepatocytes infected with HCV in vitro. Importantly, the expression levels of KLRG1 are inversely associated with the capacity of NK cells to proliferate and to produce gamma interferon (IFN-γ) but positively associated with apoptosis of NK cells in response to inflammatory cytokine stimulation. KLRG1(+) NK cells, including CD56(bright) and CD56(dim) subsets, exhibit impaired cell activation and IFN-γ production but increased apoptosis compared to KLRG1(-) NK cells, particularly in HCV-infected individuals. Importantly, blockade of KLRG1 signaling significantly recovered the impaired IFN-γ production by NK cells from HCV-infected subjects. Blockade of KLRG1 also enhanced the impaired phosphorylation of Akt (Ser473) in NK cells from HCV-infected subjects. Taken together, these results indicate that KLRG1 negatively regulates NK cell numbers and functions via the Akt pathway, thus providing a novel marker and therapeutic target for HCV infection.
The skin fungus‐induced Th1‐ and Th2‐related cytokine, chemokine and prostaglandin E<sub>2</sub> production in peripheral blood mononuclear cells from patients with atopic dermatitis and psoriasis vulgaris (2002)

AD patients manifest Th2-skewed responses to MF, CA and TR, which may be partially attributable to the enhanced PGE2 responses to these fungi. PV patients manifest Th1-skewed responses to MF.
Design of a new portable fork detector for research reactor spent fuel (1995)

There are many situations in nonproliferation and international safeguards when one needs to verify spent research-reactor fuel. Special inspections, a reactor coming under safeguards for the first time, and failed surveillance are prime examples. Several years ago, Los Alamos developed the FORK detector for the IAEA and EURATOM. This detector, together with the GRAND electronics package, is used routinely by inspectors to verify light-water-reactor spent fuels. Both the FORK detector and the GRAND electronics technologies have been transferred and are now commercially available. Recent incidents in the world indicate that research-reactor fuel is potentially a greater concern for proliferation than light-water-reactor fuels. A device similar to the FORK/GRAND should be developed to verify research-reactor spent fuels because the signals from light-water-reactor spent fuel are quite different than those from research-reactor fuels.
Finite element analysis of underwater capacitor micromachined ultrasonic transducers (2002)

A simple electro-mechanical equivalent circuit model is used to predict the behavior of capacitive micromachined ultrasonic transducers (cMUT). Most often, cMUTs are made in silicon and glass plates that are in the 0.5 mm to 1 mm range in thickness. The equivalent circuit model of the cMUT lacks important features such as coupling to the substrate and the ability to predict cross-talk between elements of an array of transducers. To overcome these deficiencies, a flnite element model of the cMUT is constructed using the commercial code ANSYS. Calculation results of the complex load impedance seen by single capacitor cells are presented, then followed by a calculation of the plane wave real load impedance seen by a parallel combination of many cells that are used to make a transducer. Cross-talk between 1-D array elements is found to be due to two main sources: coupling through a Stoneley wave propagating at the transducer-water interface and coupling through Lamb waves propagating in the substrate. To reduce the cross-talk level, the effect of structural variations of the substrate are investigated, which includes a change of its thickness and etched trenches or polymer walls between array elements.
100-Gbit/s optical-packet self-routing by self serial-to-parallel conversion (2002)

For the first time, self-SPC has been demonstrated for a 100-Gb/s optical packet. Two bits in the packet had automatic output which was parallel by using an all-optical SPC module capable of 18-ch parallel conversion and a control optical pulse created by the single pulse generator. We also demonstrated 1/spl times/4 self-routing based on 2-bit label recognition by self-SPC. This experiment was restricted to only 2-bit label recognition, but we believe that, by using an 18-ch receiver array and CMOS address recognition circuits with an address table, the label recognition of more than a quarter of a million addresses on ultrafast burst optical packets could be achieved by a self-SPC system.
Liquid nitrogen cooled HTS motor for ship propulsion (2006)

A pod propulsion system has been receiving attention as a measure to satisfy the Kyoto Protocol, which was activated in February 2005. A high-temperature superconducting motor is thought to maximize the merit of the pod propulsion system. Sumitomo Electric, University of Fukui, IHI and other organizations have developed the world's first liquid nitrogen cooled high-temperature superconducting motor for the pod propulsion system. The employed axial gap motor structure is explained by comparing the conventional radial gap motor. The merits of the axial gap motor using high-temperature superconductor are explained. Merits of iron core installation also explained. Two prototype motors have been manufactured and demonstrated. These motor employs commercialized bismuth based superconductor, which is supplied by Sumitomo Electric. A 400 kW motor production is planned and a prototype copper motor has been manufactured and tested. The results show good agreement with the simulation
Cognitive functionality in next generation wireless networks: standardization efforts (2008)

This article discusses recent standardization efforts related to cognitive radio focusing on the work of IEEE Standards Coordinating Committee 41, formerly known as IEEE 1900. Some important tasks to be performed by the CR standardization community also are presented. These tasks will expedite the introduction of CR devices to the market while promoting a fair use of scarce radio resources. Some avenues for using the currently available standards for rapid deployment of CR devices, such as ISO standards, also are discussed.
Investigation of Heat Stabilizers for Nitrocellulose Film. (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigation of Heat Stabilizers for Nitrocellulose Film.G. P. Sollott and Fred EinbergCite this: J. Chem. Eng. Data 1959, 4, 3, 266–272Publication Date (Print):July 1, 1959Publication History Published online1 May 2002Published inissue 1 July 1959https://pubs.acs.org/doi/10.1021/je60003a020https://doi.org/10.1021/je60003a020research-articleACS PublicationsRequest reuse permissionsArticle Views120Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Proteome Reference Map and Proteomic Analysis of Bifidobacterium longum NCC2705 (2006)

A comprehensive proteomic study was carried out to identify and characterize proteins expressed by Bifidobacterium longum NCC2705. A total of 708 spots representing 369 protein entries were identified by MALDI-TOF-MS and/or ESI-MS/MS. Isoelectric point values estimated by gel electrophoresis matched closely with their predicted ones, although some discrepancies exist suggesting that post-translational protein modifications might be common in B. longum. The identified proteins represent 21.4% of the predicted 1727 ORFs in the genome and correspond to 30% of the predicted proteome. Moreover 95 hypothetical proteins were experimentally identified. This is the first compilation of a proteomic reference map for the important probiotic organism B. longum NCC2705. The study aimed to define a number of cellular pathways related to important physiological processes at the proteomic level. Proteomic comparison of glucose- and fructose-grown cells revealed that fructose and glucose are catabolized via the same degradation pathway. Interestingly the sugar-binding protein specific to fructose (BL0033) and Frk showed higher levels of expression in cells grown on fructose than on glucose as determined by semiquantitative RT-PCR. BL0033 time course and concentration experiments showed that the induction time and fructose concentration correlates to increased expression of BL0033. At the same time, an ABC (ATP-binding cassette) transporter ATP-binding protein (BL0034) was slightly up-regulated in cells grown on fructose compared with glucose. All of the above results suggest that the uptake of fructose into the cell may be conducted by a specific transport system in which BL0033 might play an important role.
Pathways to success (2000)

Evidence linking Down Syndrome with Alzheimer’s Disease means that specialist services must put in place a comprehensive screening process if people are to receive appropriate support. In this article, Karen McKenzie and her colleagues describe how a multi disciplinary care pathway was developed for adults with Down Syndrome in one area.
An Assessment of the Business Case for Communications-Based Train Control (2015)

This study examines the retrofit of Communications-Based Train Control (CBTC) on two North American transit properties, namely New York City Transit (NYCT) and the Southeastern Pennsylvania Transportation Authority (SEPTA), with the objective of assessing the benefits realized and implementation challenges experienced. The study validates broader industry experience that CBTC offers benefits that cannot be achieved with prior generations of signaling technology. The study also highlights that the challenges in upgrading the signaling/train control systems on an existing high-capacity mass transit system should not be underestimated. To this end, the study recommends that an increased emphasis on a Systems Engineering process be adopted throughout the life-cycle of a CBTC upgrade project. This study provides transit agencies contemplating a CBTC upgrade program with a better understanding of CBTC technology, as well as a tool to assist in the planning, business case development, and management of CBTC projects.
Artificial neural networks (1988)

Examines the following questions associated with artificial neural networks: why people are interested in artificial neural networks; what artificial neural networks are, from the point of view of electronic circuits, and how they work; how they can be programmed and made to solve particular problems; and whether interesting problems can actually be put on such networks. The author then describes the current state of artificial neural network technology and the resulting challenges to people working on electronic devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>