gebhart/patrepeval huggingface dataset:
A reconfigurable multi-function computing cache architecture (2000)

A considerable portion of a chip is dedicated to a cache memory in a modern microprocessor chip. However, some applications may not actively need all the cache storage, especially the computing bandwidth limited applications. Instead, such applications may be able to use some additional computing resources. If the unused portion of the cache could serve these computation needs, the on-chip resources would be utilized more efficiently. This presents an opportunity to explore the reconfiguration of a part of the cache memory for computing. In this paper, we present a cache architecture to convert a cache into a computing unit for either of the following two structured computations, FIR and DCT/IDCT. In order to convert a cache memory to a function unit, we include additional logic to embed multi-bit output LUTs into the cache structure. Therefore, the cache can perform computations when it is reconfigured as a function unit. The experimental results show that the reconfigurable module improves the execution time of applications with a large number of data elements by a large factor (as high as 50 and 60). In addition, the area overhead of the reconfigurable cache module for FIR and DCT/IDCT is less than the core area of those functions. Our simulations indicate that a reconfigurable cache does not take a significant delay penalty compared with a dedicated cache memory. The concept of reconfigurable cache modules can be applied at Level-2 caches instead of Level-1 caches to provide an active-Level-2 cache similar to active memories.
Inhibition of Acrosin Activity with a Trypsin Inhibitor Blocks Human Sperm Penetration of the Zona Pellucida (1993)

To evaluate the role of acrosin in human sperm penetration of the zona pellucida (ZP), sperm-oocyte interaction was studied after acrosin activity was blocked with soybean trypsin inhibitor (SBTI). Oocytes that had failed to fertilize because of sperm pathology in a clinical in vitro fertilization program were used to assess sperm binding to and penetration into the ZP. The acrosome reaction of sperm bound to the ZP was determined using fluorescein-labeled Pisum sativum agglutinin after sperm were removed from the ZP. Acrosin activity, determined by a gelatin substrate film method, was severely inhibited by 2 mg/ml SBTI. Sperm motility and movement characteristics, assessed by a Hamilton-Thorn motility analyzer, were unchanged after 6-h incubation with SBTI. Inhibition of acrosin activity did not affect the number of sperm bound to the ZP but completely blocked sperm penetration of the ZP after a 5-h incubation. SBTI did not influence the spontaneous acrosome loss of sperm in culture medium after 6-h and 20-h incubations, but the percentage of acrosome-reacted sperm bound to the ZP was significantly reduced. It was concluded that acrosin activity plays a key role in sperm-zona interaction in humans. Motile sperm are unable to penetrate the ZP when acrosin activity is inhibited. This might result from interference with a phase of the sperm-ZP binding reaction or with a lytic action of acrosin. Also, acrosin may be involved in the acrosome reaction induced by sperm binding to the ZP.
Wastewater treatment with diamond electrodes (2000)

Boron doped diamond films have been deposited by large area hot-filament CVD (HFCVD) on silicon, silicon carbide, and different industrial electrode materials, like niobium, tantalum, titanium, tungsten, zirconium, and graphite on areas up to 40 cm * 60 cm. These diamond electrodes have been characterized with regard to their material and electrochem. properties. The oxidn. of org. compds. has been studied using alcs., org. acids and halogenated arom. mols. These org. model mols. are oxidized to CO2 without major amts. of other detectable byproducts even at very low concns. (< 3 ppm). Concd. (1 M) and dild. (3.1 * 10-4 M) cyanide solns. have been oxidized on diamond electrodes both in the presence and in the absence of chloride ions. At low concns., the oxidn. process is strongly catalyzed by the presence of Cl-. These exptl. data demonstrate the applicability of diamond electrodes for industrial processes of wastewater treatment. [on SciFinder (R)]
Differential Roles of NMDA Receptor Subtypes NR2A and NR2B in Dendritic Branch Development and Requirement of RasGRF1 (2010)

N-methyl-D-aspartate receptors (NMDARs) are known to regulate axonal refinement and dendritic branching. However, because NMDARs are abundantly present as tri-heteromers (e.g., NR1/NR2A/NR2B) during development, the precise role of the individual subunits NR2A and NR2B in these processes has not been elucidated. Ventral spinal cord neurons (VSCNs) provide a unique opportunity to address this problem, because the expression of both NR2A and NR2B (but not NR1) is downregulated in culture. Exogenous NR2A or NR2B were introduced into these naturally NR2-null neurons at 4 DIV, and electrophysiological recordings at 11 DIV confirmed that synaptic NR1NR2A receptors and NR1NR2B receptors were formed, respectively. Analysis of the dendritic architecture showed that introduction of NR2B, but not NR2A, dramatically increased the number of secondary and tertiary dendritic branches of VSCNs. Whole cell patch-clamp recordings further indicated that the newly formed branches in NR2B-expressing neurons were able to establish functional synapses because the frequency of miniature AMPA-receptor synaptic currents was increased. Using previously described mutants, we also found that disruption of the interaction between NR2B and RasGRF1 dramatically impaired dendritic branch formation in VSCNs. The differential role of the NR2A and NR2B subunits and the requirement for RasGRF1 in regulating branch formation was corroborated in hippocampal cultures. We conclude that the association between NR1NR2B-receptors and RasGRF1 is needed for dendritic branch formation in VSCNs and hippocampal neurons in vitro. The dominated NR2A expression and the limited interactions of this subunit with the signaling protein RasGRF1 may contribute to the restricted dendritic arbor development in the adult CNS.
Detecting dings and dents on specular car body surfaces based on optical flow (2017)

This paper introduces a new approach to detect defects cataloged as dings and dents on car body surfaces, which is currently one of the most important issues facing quality control in the automotive industry. Using well-known optical flow algorithms and the deflectometry principle, the method proposed in this work is able to detect all kind of anomalies on specular surfaces. Hence, our method consists of two main steps: first, in the pre-processing step, light patterns projected on the body surface sweep uniformly the area of inspection, whilst a new image fusion law, based on optical flow, is used to obtain a resulting fused image holding the information of all variations suffered by the projected patterns during the sweeping process, indicating the presence of anomalies; second, a new post-processing step is proposed that avoids the need of using pre-computed reference backgrounds in order to differentiate defects from other body features such as style-lines. To that end, the image background of the resulting fused image is estimated in the first place through a method based on blurring the image according to the direction of each pixel. Afterwards, the estimated image background is used in a new subtraction law through which defects are well differentiated from other surface deformations, allowing the detection of defects in the entire illuminated area. In addition, since our approach, together with the system used, computes defects in less than 15 s, it satisfies the assembly plants time requirements. Experimental results presented in this paper are obtained from the industrial automatic quality control system QEyeTunnel employed in the production line at the Mercedes-Benz factory in Vitoria, Spain. A complete analysis of the algorithm performance will be shown here, together with several tests proving the robustness and reliability of our proposal.
Structural and Functional Roles of Asparagine 175 in the Cysteine Protease Papain (1995)

The role of the asparagine residue in the Cys-His-Asn "catalytic triad" of cysteine proteases has been investigated by replacing Asn175 in papain by alanine and glutamine using site-directed mutagenesis. The mutants were expressed in yeast and kinetic parameters determined against the substrate carbobenzoxy-L-phenylalanyl-(7-amino-4-methylcoumarinyl)- L-arginine. At the optimal pH of 6.5, the specificity constant (k(cat)/KM)obs was reduced by factors of 3.4 and 150 for the Asn175-->Gln and Asn175-->Ala mutants, respectively. Most of this effect was the result of a decrease in k(cat), as neither mutation significantly affected KM. Substrate hydrolysis by these mutants is still much faster than the non-catalytic rate, and therefore Asn175 cannot be considered as an essential catalytic residue in the cysteine protease papain. Detailed analyses of the pH activity profiles for both mutants allow the evaluation of the role of the Asn175 side chain on the stability of the active site ion pair and on the intrinsic activity of the enzyme. Alteration of the side chain at position 175 was also found to increase aggregation and proteolytic susceptibility of the proenzyme and to affect the thermal stability of the mature enzyme, reflecting a contribution of the asparagine residue to the structural integrity of papain. The strict conservation of Asn175 in cysteine proteases might therefore result from a combination of functional and structural constraints.
Seizure disorders: Part 1. Classification and diagnosis (2001)

Seizures are the most common acute neurologic problem in the United States Epilepsy (recurrent seizures) is the third most common serious neurologic disorder, following stroke and Alzheimer's disease. The age-adjusted incidence of newly diagnosed epilepsy is 44 per 100,000 person-years.
Depletion of intracellular Ca <sup>2+</sup> stores, phosphorylation of eIF2α, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole (1998)

Regulation of translation initiation plays a critical role in the control of cell growth and division in eukaryotic cells. Translation of many growth regulatory proteins including cyclins depends critically on translation initiation factors because their mRNAs are translated inefficiently. We report that clotrimazole, a potent antiproliferative agent both in vitro and in vivo, inhibits cell growth by interfering with translation initiation. In particular, clotrimazole causes a sustained depletion of intracellular Ca2+ stores, which results in activation of PKR, phosphorylation of eIF2alpha, and thereby in inhibition of protein synthesis at the level of translation initiation. Consequently, clotrimazole preferentially decreases the expression of the growth promoting proteins cyclin A, E and D1, resulting in inhibition of cyclin-dependent kinase activity and blockage of cell cycle in G1.
New Insights into the Lifestyle of the Cold-Loving SM1 Euryarchaeon: Natural Growth as a Monospecies Biofilm in the Subsurface (2006)

In the surface waters of sulfidic springs near Regensburg, Bavaria, Germany, the SM1 euryarchaeon, together with filamentous bacteria, forms the recently described unique string-of-pearls community. In addition to naturally occurring string-of-pearls communities, the growth of these communities was also observed on polyethylene nets provided as an artificial attachment material in the streamlets of springs. In order to learn more about the distribution and origin of the SM1 euryarchaeon and its possible occurrence in the subsurface, polyethylene nets were incubated as deeply as possible in different spring holes. After a short residence time, slime-like, milky drops, almost completely composed of SM1 euryarchaeon, were attached to the nets, indicating that this organism grows independent of a partner in deeper earth layers. A newly designed in situ biofilm trapping system allowed the quantitative harvesting of organisms exhibiting this newly discovered lifestyle of the SM1 euryarchaeon for detailed biological studies. The discovery of naturally occurring archaeal biofilms extends our knowledge of the biology and ecological significance of archaea in their environments.
Role of Protease Inhibitors in Preventing Recurrent Oral Candidosis in Patients With HIV Infection: A Prospective Case-Control Study (1999)

This study was conducted to evaluate the efficacy of highly active anti-retroviral therapy (HAART) in preventing recurrence of oral candidosis (OC) associated with HIV. A prospective case-controlled observational study was performed in an inner-city university-hospital HIV/AIDS clinic. Ninety-three HIV-positive study subjects with a history of recurrent OC were divided into two groups: protease inhibitors (PI)-treated patients (group 1, n = 30) and non-PI-treated patients (group 2, n = 63). Study subjects were matched for sex, age, stage of HIV infection, and peripheral CD4+ T-cell counts. The non-PI-treated group was further subdivided into the following three subgroups: HIV-positive study subjects treated with reverse transcriptase inhibitors (RTI; groups 2a and 2c) and HIV-positive study subjects not treated with RTIs (group 2b). Group 2c met the same inclusion criteria as group 2a had but was matched 6 months after the beginning of the study. We also assessed in vitro peripheral blood mononuclear cells (PBMC) and their lymphoproliferative response, as well as cutaneous delayed-type hypersensitivity (DTH) response to Candida-associated antigens in a randomly selected sample of study subjects divided into those treated with PIs and those who were not. During a 1-year follow-up, OC was diagnosed in 2 (7%) PI-treated and 23 (36%) non-PI-treated patients (p<.001). In addition to comparing findings in group 1 with those in group 2c, OC was detected in 14 (50%) non-PI-treated patients compared with no HAART-treated study subjects (p<.001). Only 41% of PI-treated study subjects had positive lymphoproliferative response in PBMCs and none was positive in terms of DTH to Candida antigens (p = not significant versus non-PI-treated study subjects). While objectively demonstrating a beneficial effect of HAART in preventing recurrence of OC infections, our findings suggest this effect cannot be not fully accounted for by reconstitution of anti-Candida cell-mediated immunity, given that other mechanisms, even of a nonimmune nature, could have some effect.
Instrumental Crispness and Crunchiness of Roasted Hazelnuts and Correlations with Sensory Assessment (1999)

ABSTRACT Crispness and crunchiness of 15 samples of roasted hazelnuts were investigated. Force deformation curves from compression cell testing were analyzed and mechanical response variables were determined for roasted hazelnuts. Regression equations based on roasting air temperature, air velocity, and roasting time explained (R 2 _0.9 –0.98, p < 0.001) the mechanical response variables. Samples were also evaluated by a quantitative descriptive panel. Among the mechanical response variables, the first fracture point (F 1 ) observed on the force deformation curve and the slope (S 2 ) for the line between the first and second fracture points strongly correlated (inverse) with sensory crispness (R =–0.96) and crunchiness (R _–0.92), respectively.
Simulation of Magnetically Triggered ${\rm MgB}_{2}$ Switches (2010)

Superconducting synchronous machines require Direct Current (DC) excitation for their field windings which can be achieved via brushless exciters or by direct connection to current leads. However, the resulting heat loads limit their application. An excitation system consisting of a High-temperature Superconducting (HTS) full wave rectified flux pump eliminates these issues and enables operation at high currents. Rectification is achieved through superconducting magnetic switches, which also allow persistent current operation. Initial experimental results demonstrated that magnetic switching in MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> can be achieved without any significant temperature increase, enabling a fast recovery of the switches to the superconducting state. An empirical model has been developed which allows estimating MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> switch performance over the operational range needed for rotating machine excitation. The model uses measured critical current densities and n-values of commercially available MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> conductor and enables the design of optimized switches for field winding excitation and other applications.
Regulation of fructose-6-phosphate 2-kinase by phosphorylation and dephosphorylation: possible mechanism for coordinated control of glycolysis and glycogenolysis. (1982)

The kinetic properties and the control mechanism of fructose-6-phosphate 2-kinase (ATP: D-fructose-6-phosphate 2-phosphotransferase) were investigated. The molecular weight of the enzyme is approximately 100,000 as determined by gel filtration. The plot of initial velocity versus ATP concentration is hyperbolic with a Km of 1.2 mM. However, the plot of enzyme activity as a function of fructose-6-phosphate is sigmoidal. The apparent K0.5 for fructose-6-phosphate is 20 microM. Fructose-6-phosphate 2-kinase is inactivated by the catalytic subunit of cyclic AMP-dependent protein kinase, and the inactivation is closely correlated with phosphorylation. The enzyme is also inactivated by phosphorylase kinase in the presence of Ca2+ and calmodulin. The phosphorylated fructose-6-phosphate 2-kinase, which is inactive, is activated by phosphorylase phosphatase and alkaline phosphatase. The possible physiological significance of these observations in the coordinated control of glycogen metabolism and glycolysis is discussed.
Detoxifying symbiosis: microbe-mediated detoxification of phytotoxins and pesticides in insects (2018)

Covering: up to 2018 Insects live in a world full of toxic compounds such as plant toxins and manmade pesticides. To overcome the effects of these toxins, herbivorous insects have evolved diverse, elaborate mechanisms of resistance, such as toxin avoidance, target-site alteration, and detoxification. These resistance mechanisms are thought to be encoded by the insects' own genomes, and in many cases, this holds true. However, recent omics analyses, in conjunction with classic culture-dependent analyses, have revealed that a number of insects possess specific gut microorganisms, some of which significantly contribute to resistance against phytotoxins and pesticides by degrading such chemical compounds. Here, we review recent advances in our understanding on the symbiont-mediated degradation of natural and artificial toxins, with a special emphasis on their underlying genetic basis, focus on the importance of environmental microbiota as a resource of toxin-degrading microorganisms, and discuss the ecological and evolutionary significance of these symbiotic associations.
Mass transfer during osmotic dehydration using acoustic cavitation (2005)

An experimental study on intensifying osmotic dehydration was carried out in a state of nature and with acoustic cavitation of different cavitating intensity (0.5A, 0.7A and 0.9A) respectively, in which the material is apple slice of 5mm thickness. The result showed that acoustic cavitation remarkably enhanced the osmotic dehydration, and the water loss was accelerated with the increase of cavitating intensity. The water diffusivity coefficients ranged from 1.8×10^(-10)m^2•s^(-1) at 0.5A to 2.6×10^(-10)m^2•s^(-1) at 0.9A, and solute diffusivity coefficients ranged from 3.5×10^(-11)m^2•s^(-1) at 0.5A to 4.6×10^(-11)m^2•s^(-1) at 0.9A. On the basis of experiments, a mathematical model was established about mass transfer during osmotic dehydration, and the numerical simulation was carried out. The calculated results agree well with experimental data, and represent the rule of mass transfer during osmotic dehydration intensified by acoustic cavitation.
Real scale experimental devices for stator core fault analysis (2011)

That paper presents two real scale experimental devices manufactured to study the stator interlaminar short circuit fault in large generators. The first one is based on a stack of lamination in which faulty sheets can be inserted. The second one is a partial exciter of a real 125MW turbo generator. These devices are useful to validate experimental procedures for detection of stator core faults.
Determining the adventitious leakage of buildings at low pressure. Part 1: uncertainties (2007)

Part 1 of this paper examines the uncertainties (errors) inherent in the determination of the low-pressure leakage of a building envelope. Current procedures use high-pressure data (typically 50 Pa) as a measure of the infiltration potential of an envelope. In reality, infiltration occurs at much lower pressures (typically 4 Pa). As a consequence, large uncertainties are inherent in the current procedures. It is shown that a technique for direct measurement of Q 4 could reduce the uncertainty by a factor of three or more. One of the keys to such a measurement is to consecutively measure Dp with and without an imposed flow in a short time. In Part 2 of this paper, a technique is described that enables such measurements to be made.
Two-dimensional DNA fingerprinting of human individuals. (1989)

The limiting factor in the presently available techniques for the detection of DNA sequence variation in the human genome is the low resolution of Southern blot analysis. To increase the analytical power of this technique, we applied size fractionation of genomic DNA restriction fragments in conjunction with their sequence-dependent separation in denaturing gradient gels; the two-dimensional separation patterns obtained were subsequently transferred to nylon membranes. Hybridization analysis using minisatellite core sequences as probes resulted in two-dimensional genomic DNA fingerprints with a resolution of up to 625 separated spots per probe per human individual; by conventional Southern blot analysis, only 20-30 bands can be resolved. Using the two-dimensional DNA fingerprinting technique, we demonstrate in a small human pedigree the simultaneous transmission of 37 polymorphic fragments (out of 365 spots) for probe 33.15 and 105 polymorphic fragments (out of 625 spots) for probe 33.6. In addition, a mutation was detected in this pedigree by probe 33.6. We anticipate that this method will be of great use in studies aimed at (i) measuring human mutation frequencies, (ii) associating genetic variation with disease, (iii) analyzing genomic instability in relation to cancer and aging, and (iv) linkage analysis and mapping of disease genes.
Small signal impedance measurement in droop controlled AC microgrids (2014)

Stable operation of microgrids is highly influenced by characteristics of generators due to their small size and inertia and fast and variable dynamics. Recent work has shown that microgird stability can be determined by analysis of small signal impedances at the point of interconnection. The purpose of small signal impedance measurement is to verify the analytical models of single devices and to provide measured impedances where analytical models are not available, so that stability may be established. Small signal impedance measurement typically involves in-situ injection of currents or voltages superimposed upon the operating system. In droop-controlled microgrids, since the frequency is a function of the power demand, the injection has to be independent of the frequency. In this paper an injection approach is proposed using a three phase buck converter. Analytical models using dynamic phasors are compared to measurement results obtained in a laboratory microgrid. The injection method and the incremental phasor models of passive loads are verified and small signal impedance measurements of an islanded and grid-connected microgrid are obtained including a voltage source PWM converter.