gebhart/patrepeval huggingface dataset:
Pharmacokinetics of fluconazole following intravenous and oral administration and body fluid concentrations of fluconazole following repeated oral dosing in horses (2001)

Bioavailability of fluconazole was high after oral administration to horses. Long-term oral administration maintained plasma and body fluid concentrations of fluconazole above the mean inhibitory concentration (8.0 mg/ml) reported for fungal pathogens in horses. Fluconazole may be an appropriate agent for treatment of fungal infections in horses.
Low-Temperature Performance Advantages for Oils Using Hydrodewaxed Base Stocks (1983)

<div class="htmlview paragraph">Single and multigrade engine oils formulated with catalytic hydrodewaxed (MLDW) base stocks possess low-temperature fluidity properties superior to counterpart products using conventional solvent dewaxed base stocks. This low-temperature benefit for MLDW oils is demonstrated in CCS and MRV viscosity measurements and cold engine cranking studies. This advantage is a natural consequence of the composition differences imposed by the respective dewaxing processes. The MLDW process is more selective and more efficient than solvent dewaxing in the removal of paraffins to reduce lube oil pour point. It follows that MLDW oils have fewer paraffins available for wax-gel formation at low temperatures. The lower paraffin content is also responsible for the lower VI values for the MLDW base stocks. Thus, the superior low-temperature performance of MLDW oils is contrary to viscosity-temperature extrapolations.</div>
PET Imaging and Biodistribution of Chemically Modified Bacteriophage MS2 (2012)

The fields of nanotechnology and medicine have merged in the development of new imaging and drug delivery agents based on nanoparticle platforms. As one example, a mutant of bacteriophage MS2 can be differentially modified on the exterior and interior surfaces for the concurrent display of targeting functionalities and payloads, respectively. In order to realize their potential for use in in vivo applications, the biodistribution and circulation properties of this class of agents must first be investigated. A means of modulating and potentially improving the characteristics of nanoparticle agents is the appendage of PEG chains. Both MS2 and MS2-PEG capsids possessing interior DOTA chelators were labeled with (64)Cu and injected intravenously into mice possessing tumor xenografts. Dynamic imaging of the agents was performed using PET-CT on a single animal per sample, and the biodistribution at the terminal time point (24 h) was assessed by gamma counting of the organs ex vivo for 3 animals per agent. Compared to other viral capsids of similar size, the MS2 agents showed longer circulation times. Both MS2 and MS2-PEG bacteriophage behaved similarly, although the latter agent showed significantly less uptake in the spleen. This effect may be attributed to the ability of the PEG chains to mask the capsid charge. Although the tumor uptake of the agents may result from the enhanced permeation and retention (EPR) effect, selective tumor imaging may be achieved in the future by using exterior targeting groups.
CONEXIÓN INALÁMBRICA TOTAL Y GRATUITA, EN MARCHA (2010)

COMO UN COMPLEMENTO A LA RED INALAMBRICA UNIVERSITARIA (RIU), LA UNAM PUSO EN MARCHA EL SERVICIO DE CONEXION INALAMBRICA A INTERNET INFINITUM MOVIL, QUE PERMITIRA EL ACCESO A CONTENIDOS ACADEMICOS Y SERVICIOS DESDE DISPOSITIVOS PORTATILES. AMBOS SON GRATUITOS PARA LA COMUNIDAD DE ESTA CASA DE ESTUDIOS.
Control of capillary formation by membrane‐anchored extracellular inhibitor of phospholipase A<sub>2</sub> (2002)

Secretory phospholipase A(2) (sPLA(2)) has been reported to be involved in cell proliferation in general and in endothelial cell migration, processes required for capillary formation. Subsequently, we examined the potential control of angiogenesis by sPLA(2) inhibition, using a cell-impermeable sPLA(2) inhibitor composed of N-derivatized phosphatidyl-ethanolamine linked to hyaluronic acid. This inhibitor effectively inhibits the proliferation and migration of human bone marrow endothelial cells in a dose-dependent manner, and suppresses capillary formation induced by growth factors involved in vascularization of tumors and of atherosclerotic plaques. It is proposed that sPLA(2) inhibition introduces a novel approach in the control of cancer development and atherosclerosis.
Myofilament Protein Phosphorylation by PKC in Genetically Engineered Adult Cardiac Myocytes (2003)

Virus-based gene transfer results in the rapid and efficient expression of individual contractile proteins within the myofilaments of adult cardiac myocytes (1–3). This ability to express genetically modified contractile proteins in myocytes now makes it possible to investigate the relative phosphorylation of a given contractile protein as it resides within the intact myofilament. Contractile proteins, including troponin I (TnI), troponin T (TnT), myosin light chain 2 (MLC2), and myosin binding protein C (MyBPC) are in vitro targets for protein kinase C (PKC) phosphorylation (4). Several protocols have been developed to detect contractile protein phosphorylation using 32P-ATP and PKC preparations (5–7). However, questions remain about whether these proteins are phosphorylated by agonist-activated PKC in intact adult cardiac myocytes (5,8,9). Thus, there is a need to identify the relative phosphorylation of myofilament proteins in response to PKC activation in adult cardiac myocytes. This goal is accomplished by studying myofilament protein phosphorylation in genetically modified myocytes expressing contractile proteins with and without modified phosphorylation sites.
A Position Effect on the Expression of a tRNA Gene Mediated by the <i>SIR</i> Genes in <i>Saccharomyces cerevisiae</i> (1986)

The SIR genes of Saccharomyces cerevisiae are responsible for the position-dependent regulation of the a and alpha mating-type genes. Previous work by others has shown that the products of the SIR genes prevent the accumulation of stable transcripts of the a and alpha genes at HML and HMR. Results of this study establish that this regulation is a region-specific effect rather than a gene-specific effect since expression of a tRNA gene placed at HMR is repressed by the products of the SIR genes.
Expression of the gene encoding glycerol‐3‐phosphate dehydrogenase (<i>glpD</i>) in <i>Bacillus subtilis</i> is controlled by antitermination (1991)

The Bacillus subtilis glpD gene encodes glycerol-3-phosphate (G3P) dehydrogenase. A sigma A type promoter and the transcriptional startpoint for glpD were identified. Between the transcriptional startpoint and glpD there is an inverted repeat followed by a run of T residues. The inverted repeat prevents expression of a reporter gene, xylE, when positioned between this gene and a constitutive promoter. Expression of xylE, like expression of glpD, is induced by G3P and repressed by glucose. Induction also requires the product of the glpP gene. Our results suggest that glpD expression is controlled by antitermination of transcription. The inverted repeat appears to be a target for induction by G3P and GlpP. We speculate that glucose repression is mediated via an inhibitory effect on synthesis or activity of GlpP.
Conversion of a 2-terminal-pair bridge to a 4-terminal-pair bridge for increased range and precision in impedance measurements (2002)

A new 4-terminal-pair bridge, capable of a relative uncertainty of 1 in 10/sup 9/, has been constructed at NIST by converting a 2-terminal pair bridge. The conversion requires only addition of components which are easily removed if 2-pair measurements are to be made. The design and testing of this bridge are described.
Novel Oncogenic <i>PDGFRA</i> Mutations in Pediatric High-Grade Gliomas (2013)

Abstract The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%. Diffuse intrinsic pontine glioma (DIPG) comprise a subset of HGG that arise in the brainstem almost exclusively in children. Genome-wide analyses of copy number imbalances previously showed that platelet-derived growth factor receptor α (PDGFRA) is the most frequent target of focal amplification in pediatric HGGs, including DIPGs. To determine whether PDGFRA is also targeted by more subtle mutations missed by copy number analysis, we sequenced all PDGFRA coding exons from a cohort of pediatric HGGs. Somatic-activating mutations were identified in 14.4% (13 of 90) of nonbrainstem pediatric HGGs and 4.7% (2 of 43) of DIPGs, including missense mutations and in-frame deletions and insertions not previously described. Forty percent of tumors with mutation showed concurrent amplification, whereas 60% carried heterozygous mutations. Six different mutations impacting different domains all resulted in ligand-independent receptor activation that was blocked by small molecule inhibitors of PDGFR. Expression of mutants in p53-null primary mouse astrocytes conferred a proliferative advantage in vitro and generated HGGs in vivo with complete penetrance when implanted into brain. The gene expression signatures of these murine HGGs reflected the spectrum of human diffuse HGGs. PDGFRA intragenic deletion of exons 8 and 9 were previously shown in adult HGG, but were not detected in 83 nonbrainstem pediatric HGG and 57 DIPGs. Thus, a distinct spectrum of mutations confers constitutive receptor activation and oncogenic activity to PDGFRα in childhood HGG. Cancer Res; 73(20); 6219–29. ©2013 AACR.
A Piezo-Powered Floating-Gate Sensor Array for Long-Term Fatigue Monitoring in Biomechanical Implants (2008)

Measurement of the cumulative loading statistics experienced by an implant is essential for prediction of long-term fatigue failure. However, the total power that can be harvested using typical in-vivo strain levels is less than 1 muW. In this paper, we present a novel method for long-term, battery-less fatigue monitoring by integrating piezoelectric transduction with hot-electron injection on a floating-gate transistor array. Measured results from a fabricated prototype in a 0.5-mum CMOS process demonstrate that the array can sense, compute, and store loading statistics for over 70000 stress-strain cycles which can be extended to beyond 107 cycles. The measured response also shows excellent agreement with a theoretical model and the nominal power dissipation of the array has been measured to be less than 800 nW.
An efficient certificateless ID-based signcrption scheme based on pair public key (2010)

Signcryption is a method of cryptographic that combines both digital signature and public key encryption in one logical step. This paper analyzed the characteristics of mobile service and the special request of signcryption. Then one identity-based signcryption scheme using the bilinear pairing was presented. The proposed scheme is proved to be secured assuming the bilinear Diffle-Hellman problem is hard. This scheme combined the signcryption and certificateless public key cryptosystem, and it would be more efficient than existing signcryption schemes.
A novel n-port series divider using infinite wavelength phenomena (2005)

—A novel N-port series divider based on a composite right/left-handed (CRLH) transmission line (TL) supporting a wave with an infinite wavelength is presented. This novel divider evenly divides power in phase to an infinite number of ports at its infinite wavelength frequency. In addition, it is shown that the novel series divider’s performance is not dependent on the location of its output ports. The basic operating principle is based on the fact that a CRLH TL is able to support a wave with an infinite wavelength. As a result, all points along the CRLH TL have the same magnitude and phase. A 3-port series divider consisting of a 8 unit-cell CRLH TL is shown to exhibit 0.22 dB maximum magnitude difference and 1.32° maximum phase difference between output ports at its infinite wavelength frequency. In addition, a 5-port series divider consisting of a 13 unit-cell CRLH TL is fabricated and shown to exhibit 0.30 dB maximum magnitude difference and 6.3° maximum phase difference between output ports at its infinite wavelength frequency. Both simulation and experimental results are shown to support the authors’ claims.
Analysis of <i>Arabidopsis</i> genome-wide variations before and after meiosis and meiotic recombination by resequencing Landsberg <i>erecta</i> and all four products of a single meiosis (2011)

Meiotic recombination, including crossovers (COs) and gene conversions (GCs), impacts natural variation and is an important evolutionary force. COs increase genetic diversity by redistributing existing variation, whereas GCs can alter allelic frequency. Here, we sequenced Arabidopsis Landsberg erecta (Ler) and two sets of all four meiotic products from a Columbia (Col)/Ler hybrid to investigate genome-wide variation and meiotic recombination at nucleotide resolution. Comparing Ler and Col sequences uncovered 349,171 Single Nucleotide Polymorphisms (SNPs), 58,085 small and 2315 large insertions/deletions (indels), with highly correlated genome-wide distributions of SNPs, and small indels. A total of 443 genes have at least 10 nonsynonymous substitutions in protein-coding regions, with enrichment for disease-resistance genes. Another 316 genes are affected by large indels, including 130 genes with complete deletion of coding regions in Ler. Using the Arabidopsis qrt1 mutant, two sets of four meiotic products were generated and analyzed by sequencing for meiotic recombination, representing the first tetrad analysis with whole-genome sequencing in a nonfungal species. We detected 18 COs, six of which had an associated GC event, and four GCs without COs (NCOs), and revealed that Arabidopsis GCs are likely fewer and with shorter tracts than those in yeast. Meiotic recombination and chromosome assortment events dramatically redistributed genome variation in meiotic products, contributing to population diversity. In particular, meiosis provides a rapid mechanism to generate copy-number variation (CNV) of sequences that have different chromosomal positions in Col and Ler.
Regioselective Synthesis of 1-Benzyl- and 1-Methyl-4-vinylimidazole and Their Reactions with N-Phenylmaleimide (2003)

The regioselective synthesis of 1-benzyl-and 1-methyl-4vinylimidazole from 4,5-diiodoimidazole is described.Their Diels-Alder reactions with N-phenylmaleimide provide a variety of adducts, including the anticipated enamine and the corresponding aromatized isomer.However, additional products including ene adducts, a bis Diels-Alder adduct and oxidation products were isolated.
Practical Preparation of Optically Active O-Benzylglycidol from Optically Active Epichlorohydrin (1990)

Practical preparation of optically active O-benzylglycidol has been developed starting from optically active epichlorohydrin by employing either basic or acidic conditions in the key stage
<inline-formula><math display="inline" overflow="scroll"><mn>1</mn><mo>.</mo><mn>5</mn><mn>5</mn><mo>-</mo><mi>μ</mi><mstyle mathvariant="normal"><mtext>m</mtext></mstyle></math></inline-formula> silicon-based reflection-type waveguide-integrated thermo-optic switch (2003)

A novel rib waveguide-integrated switch is proposed and theoretically discussed. The device is based on the total internal reflection phenomenon (TIR) and the thermo-optic effect (TOE) in hydrogenated amorphous silicon (a-Si:H) and crystalline silicon (c-Si). It takes advantage of a bandgap-engineered a-Si:H layer to explore the properties of an optical interface between materials showing similar refractive indexes but different thermo-optic coefficients. In particular, thanks to modern plasma-enhanced chemical vapor deposition techniques, the refractive index of the amorphous film can be properly tailored to match that of c-Si at a given temperature. TIR may be achieved, however, at the interface by acting on the temperature, because the two materials have different thermo-optic coefficients. The switch is integrated in a 4-μm-wide and 3-μm-thick single-mode rib waveguide. The substrate is a silicon-on-insulator (SOI) wafer with an oxide thickness of 500 nm. The active middle region optimal length is 282 μm. The device performance is analyzed at a wavelength of 1.55 μm. It is shown that the output crosstalk and insertion loss are less than -26 and 3.5 dB, respectively.
Flow of Suspensions through Porous Media—Application to Deep Filtration (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlow of Suspensions through Porous Media—Application to Deep FiltrationJ. P. Herzig, D. M. Leclerc, and P. Le. GoffCite this: Ind. Eng. Chem. 1970, 62, 5, 8–35Publication Date (Print):May 1, 1970Publication History Published online1 May 2002Published inissue 1 May 1970https://pubs.acs.org/doi/10.1021/ie50725a003https://doi.org/10.1021/ie50725a003research-articleACS PublicationsRequest reuse permissionsArticle Views3019Altmetric-Citations741LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Metabolic rate in the right amygdala predicts negative affect in depressed patients (1998)

The role of the amygdala in major depression was investigated. Resting regional cerebral metabolic rate (rCMRglu) was measured with [18F]fluorodeoxyglucose positron emission tomography (PET) in two samples of subjects using two different PET cameras. The samples consisted of 10 and 17 medication-free depressives and 11 and 13 controls, respectively. Using coregistration of PET and magnetic resonance images, regions were individually delineated for the amygdala and thalamus, the latter of which was used as a control region. Within the depressed groups, right amygdalar rCMRglu was positively correlated with negative affect. Thalamic rCMRglu was not related to negative affect, and amygdalar rCMRglu accounted for a significant portion of variance in depressives' negative affect scores over and above the contribution of thalamic rCMRglu.
Perspectives on the AIN architecture (1992)

The advanced intelligent network (AIN) is examined in terms of its history, present day architecture, and future evolution. The history of the AIN is traced from predivestiture 800 and calling card service capabilities, through IN/1, IN/2, and IN/1+, leading to the various AIN releases. The present-day view of the AIN architecture includes the switching system and other network systems, as well as operations. The AIN functionality supported by this architecture is described from a customer point of view, by means of an illustrative service that could be provided from an AIN platform. The next steps in the AIN evolution are discussed. An appendix that provides detailed information about the AIN Release 1 call model is included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ARCPI resonant snubber for the neutral-point-clamped inverter (2000)

This paper reports a resonant snubber for the neutral-point-clamped (NPC) inverter using the auxiliary resonant commutated pole inverter (ARCPI) technique. The proposal guarantees zero-voltage switching of the main switches and zero-current switching of the auxiliary switches without incurring any voltage or current spikes across or through the main switches and without being subjected to any modulation constraints. The operation principle of the ARCPI NPC inverter is illustrated. A simple method dealing with the static overvoltage problem of the inner switches is described. Commutation durations and current stresses in the basic ARCPI circuit are analyzed. The results enable mathematical understanding and practical designing of the basic ARCPI circuit. In particular, the self-balancing quality and controlling possibility of the DC center potential in the basic ARCPI circuit are investigated. The proposal is verified by a 3 kW half-bridge ARCPI NPC inverter laboratory prototype.
Optical Wireless authentication for smart devices using an onboard ambient light sensor (2014)

As recent smartphone technologies in software and hardware keep on improving, many smartphone users envision to perform various mission critical applications on their smart-phones that were previously accomplished by using PCs. Hence, smartphone authentication has become one of the most critical security issues. Due to the relatively small smartphone form factor, the traditional user id and password typed authentication is considered as an inconvenient and time-taking approach. Taking advantage of various sensor technologies of smartphones, alternative authentication methods such as pattern, gesture, finger print, and face recognition have been actively researched. However, those authentication methods still pose one of speed, reliability, and usability issues. They are especially not suitable for the users in rugged conditions and with physical challenges. In this paper, we evaluate existing alternative smartphone authentication approaches in various usage scenarios to propose ambient light sensor based authentication for smartphones. We have designed and prototyped a challenge-based programmable Fast, Inexpensive, Reliable, and Easy-to-use (FIRE) hardware authentication token. FIRE token uses an onboard LED to transmit passwords via an Optical Wireless Signal (OWS) to the smartphone that captures, and interprets it via its ambient light sensor. FIRE token is a part of the challenge-response technique in the Inverse Dual Signature (IDS) that we designed to facilitate a multi-factor authentication for the mission critical smartphone applications. Our experiments validate that FIRE can authenticate a user on a smartphone in a simple, fast, and reliable way without compromising the security quality and user experience.
Use of a rodent neurotoxicity screening battery in the preclinical safety assessment of recombinant-methionyl human brain-derived neurotrophic factor. (1997)

Recent efforts to evaluate neurobehavioral function in adult rodents as part of preclinical safety studies have typically been directed at evaluating possible environmental neurotoxicants. With considerable basic and clinical research efforts focusing on neurotrophic factors in the treatment of various neurodegenerative diseases, the application of these neurobehavioral evaluations is expected to increase. This report describes a six-month safety study of recombinant-methionyl human brain-derived neurotrophic factor (r-metHuBDNF) in rodents that included a neurotoxicity screening battery and was undertaken to evaluate safety issues that might be anticipated in the clinical setting. R-metHuBDNF was well tolerated by rats over six months of daily subcutaneous administration at doses that exceeded the highest anticipated clinical dose by 100-fold. Although statistically significant behavioral changes were noted, they were isolated and not considered to be associated with r-metHuBDNF treatment. We conclude that the inclusion of a neurotoxicity screening battery was an important study parameter in the assessment of the preclinical safety of this neurotrophin.