gebhart/patrepeval huggingface dataset:
Storage and Quality Assessment of Platelets (1998)

Platelet concentrates stored for 5 days under currently optimal conditions at 22 C demonstrate approximately a 20-30% loss of viability as determined by CCI measurements in thrombocytopenic patients and radiolabeling studies with healthy volunteers. The functionality of platelets is substantially lost during storage. This loss appears, for most part, to be reversible upon infusion. In view of this, stored platelets should be acceptable for prophylactic treatment of thrombocytopenic patients in whom immediate hemostatic function is not critical. However, whether stored platelets are functionally adequate for immediate arrest of perioperative bleeding in surgical patients remain uncertain. Currently, a fully adequate and appropriate test that evaluates the hemostatic function of a stored platelet product is not available. In view of this, a desired goal in research and development of new platelet products may then be to attain a platelet product that is similar to fresh platelets in various haemostatic functions. Whether this is an obtainable or relevant goal remains to be seen.
Capacity of Petroleum Asphaltenes to Complex Heavy Metals. (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCapacity of Petroleum Asphaltenes to Complex Heavy Metals.J. Gordon Erdman and Phillip H. HarjuCite this: J. Chem. Eng. Data 1963, 8, 2, 252–258Publication Date (Print):April 1, 1963Publication History Published online1 May 2002Published inissue 1 April 1963https://pubs.acs.org/doi/10.1021/je60017a036https://doi.org/10.1021/je60017a036research-articleACS PublicationsRequest reuse permissionsArticle Views183Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A bone sialoprotein-binding protein from Staphylococcus aureus: a member of the staphylococcal Sdr family (2000)

Staphylococcus aureus bacteria, isolated from bone and joint infections, specifically interact with bone sialoprotein (BSP), a glycoprotein of bone and dentine extracellular matrix, via a cell-surface protein of M(r) 97000 [Yacoub, Lindahl, Rubin, Wendel, Heinegârd and Rydén, (1994) Eur. J. Biochem. 222, 919-925]. Amino acid sequences of seven trypsin fragments from the 97000-M(r) BSP-binding protein were determined. A gene encoding a protein encompassing all seven peptide sequences was identified from chromosomal DNA isolated from S. aureus strain O24. This gene encodes a protein with 1171 amino acids, called BSP-binding protein (Bbp), which displays similarity to recently described proteins of the Sdr family from S. aureus. SdrC, SdrD and SdrE encode putative cell-surface proteins with no described ligand specificity. Bbp also shows similarity to a fibrinogen-binding protein from S. epidermidis called Fbe. A serine-aspartic acid repeat sequence was found close to the cell-wall-anchoring Leu-Pro-Xaa-Thr-Gly sequence in the C-terminal end of the protein. Escherichia coli cells were transformed with an expression vector containing a major part of the bbp gene fused to the gene for glutathione S-transferase. The affinity-purified fusion protein bound radiolabelled native BSP, and inhibited the binding of radiolabelled BSP to staphylococcal cells. Serum from patients suffering from bone and joint infection contained antibodies that reacted with the fusion protein of the BSP-binding protein, indicating that the protein is expressed during an infection and is immunogenic. The S. aureus Bbp protein may be important in the localization of bacteria to bone tissue, and thus might be of relevance in the pathogenicity of osteomyelitis.
Fats and Factors: Lipid Profiles Associate with Personality Factors and Suicidal History in Bipolar Subjects (2012)

Polyunsaturated fatty acids (PUFA) have shown efficacy in the treatment of bipolar disorder, however their specific role in treating the illness is unclear. Serum PUFA and dietary intakes of PUFA associate with suicidal behavior in epidemiological studies. The objective of this study was to assess serum n-3 and n-6 PUFA levels in bipolar subjects and determine possible associations with suicidal risk, including suicidal history and relevant personality factors that have been associated with suicidality. We studied 27 bipolar subjects using the NEO-PI to assess the big five personality factors, structured interviews to verify diagnosis and assess suicidal history, and lipomics to quantify n-3 and n-6 PUFA in serum. We found positive associations between personality factors and ratios of n-3 PUFA, suggesting that conversion of short chain to long chain n-3s and the activity of enzymes in this pathway may associate with measures of personality. Thus, ratios of docosahexaenoic acid (DHA) to alpha linolenic acid (ALA) and the activity of fatty acid desaturase 2 (FADS2) involved in the conversion of ALA to DHA were positively associated with openness factor scores. Ratios of eicosapentaenoic acid (EPA) to ALA and ratios of EPA to DHA were positively associated with agreeableness factor scores. Finally, serum concentrations of the n-6, arachidonic acid (AA), were significantly lower in subjects with a history of suicide attempt compared to non-attempters. The data suggest that specific lipid profiles, which are controlled by an interaction between diet and genetics, correlate with suicidal history and personality factors related to suicidal risk. This study provides preliminary data for future studies to determine whether manipulation of PUFA profiles (through diet or supplementation) can affect personality measures and disease outcome in bipolar subjects and supports the need for further investigations into individualized specific modulations of lipid profiles to add adjunctive value to treatment paradigms.
Chemical functionalization of carbon nanotubes with 3-methacryloxypropyltrimethoxysilane (3-MPTS) (2004)

Multiwalled carbon nanotubes (MWNTs) were functionalized by oxidation with potassium permanganate using a phase transfer catalyst. The functionalized nanotubes (f-CNTs) were allowed to react with a functional chemical such as 3-methacryloxypropyltrimethoxysilane (3-MPTS). The f-CNTs and the reaction product of f-CNTs and 3-MPTS (fs-CNTs) were characterized by Fourier transform infrared and energy dispersion spectroscopy and also by scanning electron microscopy and transmission electron microscopy analysis. The MWNTs attached to the organofunctional moieties have a greater versatility for further utilization of nanotubes in different applications.
Investigation on WDM Nonlinear Impairments Arising From the Insertion of 100-Gb/s Coherent PDM-QPSK Over Legacy Optical Networks (2009)

In the perspective of smooth capacity upgrades of legacy systems, we experimentally investigate the performance of one 100-Gb/s coherent polarization-division-multiplexed quaternary-phase-shift-keying (PDM-QPSK) channel inserted in a 10-Gb/s ultra-long-haul (ULH) wavelength-division-multiplexing system relying on nonzero dispersion-shifted fibers. The impact of copropagating 10-Gb/s nonreturn-to-zero (NRZ) channels operating ULH distances onto the operational power range of the inserted 100-Gb/s coherent PDM-QPSK channel is analyzed. Moreover, the performance penalties brought by copropagating 10-Gb/s NRZ channels onto 100-Gb/s PDM-QPSK data are also analyzed depending on the number of channels in the multiplex and on the introduction of guardbands between both type of channels.
Effect of Storage on Germinability and Metabolism of Seeds from Different Whorls of Sunflower Head (2009)

Percent germination and vigour index of sunflower seeds decreased with storage period of 180 days. However, the seeds obtained from different whorls of mature sunflower head showed higher values for percent germination and vigour index for peripheral and middle positions as compared to those located at central whorls. The dry matter and oil content of cotyledons and embryonic axis was higher at 180 days as compared to ‘zero’ day. The amount of starch decreased and total soluble sugars and reducing sugars increased in cotyledons of germinating seeds collected from different positions of sunflower head. The starch and reducing sugars content was higher in embryonic axis of seeds from peripheral whorls as compared to seeds from central whorls. However, in embryonic axis, the values for these parameters were less with increased activity of invertase and decreased activity of amylases at 180 days of storage as compared to ‘zero’ day. Data suggested that seeds from peripheral positions seem to be more vigorous as compared to those from middle and central positions on sunflower head.
Collagen XXVII Organises the Pericellular Matrix in the Growth Plate (2011)

In order to characterise the function of the novel fibrillar type XXVII collagen, a series of mice expressing mutant forms of the collagen were investigated. Mice harboring a glycine to cysteine substitution in the collagenous domain were phenotypically normal when heterozygote and displayed a mild disruption of growth plate architecture in the homozygous state. Mice expressing an 87 amino acid deletion in the collagenous domain of collagen XXVII were phenotypically normal as heterozygotes whereas homozygotes exhibited a severe chondrodysplasia and died perinatally from a lung defect. Animals expressing the 87 amino acid deletion targeted specifically to cartilage were viable but severely dwarfed. The pericellular matrix of proliferative chondrocytes was disrupted and the proliferative cells exhibited a decreased tendency to flatten and form vertical columns. Collagen XXVII plays an important structural role in the pericellular extracellular matrix of the growth plate and is required for the organisation of the proliferative zone.
Endotoxin-induced ileal mucosal hyperpermeability in pigs: role of tissue acidosis (1994)

Administration of lipopolysaccharide (LPS) to experimental animals leads to diminished mesenteric perfusion, increased ileal mucosal [H+] , and increased gut epithelial permeability to hydrophilic solutes. We sought to determine whether these phenomena are causally related. Experiments were performed in anesthetized pigs. Permeability was assessed by measuring the plasma-to-lumen clearance of fluorescein isothiocyanate dextran (4,000 Da; FD-4) by a segment of ileum perfused with Ringer lactate solution. Mucosal perfusion (Qmuc) and [H4+] were estimated using laser-Doppler flowmetry and tonometry, respectively. In an initial series of experiments, we showed that mucosal permeability was linearly correlated with mucosal [H+] in animals subjected to graded degrees of mechanically induced mesenteric ischemia (n = 14, R2 = 0.58, P < 0.002) or injected with graded doses of LPS (n = 11, R2 = 0.93, P < 0.0001). In a second series of experiments, we induced mucosal acidosis in normal pigs by mechanical ventilation with either a hypoxic (n = 7) or a hypercapnic (n = 5) gas mixture. In both groups, ileal mucosal permeability to FD-4 increased significantly (P < 0.05), although transmesenteric release of lactate increased significantly only in the hypoxic group. Qmuc was unchanged in both groups. These data suggest that mucosal acidosis, even in the absence of tissue ischemia or hypoxia, increases intestinal permeability to a macromolecular hydrophilic solute. Tissue acidosis may be an important factor contributing to LPS-induced gut mucosal hyperpermeability.
Advances in constant envelope coded modulation (1991)

An overview is given of recent advances in constant envelope combined coding and modulation. Modulation codes and trellises are discussed, and major classes of trellis modulation codes are described. Continuous phase modulation is defined, and concatenations of phase codes and convolutional codes are examined. The ultimate capability of phase modulation coding and the size of CPM trellis codes are addressed. Implementation issues are considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Evaluation of ultra-low-volume insecticide dispensing systems for use in single-engined aircraft and their effectiveness against Aedes aegypti populations in South-East Asia. (1970)

An evaluation study of ultra-low-volume (ULV) spraying of insecticide from aircraft was carried out in Thailand, to determine if this technique could be used for the emergency control of Aedes aegypti, the major vector of haemorrhagic fever. A small, single-engined aircraft, a Cessna-180, was used in the trials and 2 types of spraying equipment were tested; both were found to be equally effective. The aircraft was fitted with 6 spraying nozzles and flew at an altitude of 150 feet (46 m) at a speed of 100 miles/h (161 km/h). The insecticide used was 95% technical grade malathion and swaths 75 feet wide (22.8 m) were laid down; the rate of application was 3 US fl oz/acre (219 ml/ha).Trials were made in 3 villages near Bangkok and it became apparent that a small aircraft could not produce the required even distribution of insecticide; the rate of application was therefore increased to 6 US fl oz/acre (438 ml/ha). This increased rate appeared to compensate for the narrow width of the swath and produced very satisfactory mortalities in caged mosquitos as well as in natural populations.The size and distribution of droplets was monitored by the use of oil-sensitive red dye cards which showed that there was a good penetration of insecticide into dwellings, etc. Trial results were evaluated by biting counts, bioassays of Aedes and Culex adults and larvae, Culex dips and ovitraps. Biossays indicated that the 6 US fl oz/acre rate of application was almost 100% effective in the open and produced satisfactory mortalities inside markets and dwellings.It was concluded that larger aircraft would be required to treat areas of more than 1000 acres (405 ha) and congested city areas but that the rate of application of insecticide could be considerably lower. Nevertheless, small aircraft can be useful in smaller and less congested areas.
OJ Simpson trial: we are all guilty (1996)

In analysing die OJ Simpson case, AARONETTE WHITE criticises the reactions of both white and African Americans. She believes both groups are guilty of reinforcing division and oppression by ignoring the connnections between race, gender and class
Synthesis of Benzyl Esters Using 2-Benzyloxy-1-methylpyridinium Triflate (2007)

Triethylamine (Et3N) mediates esterification reactions between the title reagent (1) and carboxylic acids. Alcohols, phenols, amides, and other sensitive functionality are not affected; a dual role for Et3N as a promoter and a scavenger is postulated. Benzyl esters are obtained from substrates including amino acid and sugar derivatives.
The leak testing program of the doublet III project (1982)

Vacuum integrity of large fusion tokamaks has become increasingly important as the complexity and requirements for cleanliness have increased. Doublet III is a large noncircular tokamak (R = 1.43 m, V = 27 m3) designed for a base pressure of 2×10−8 T and a leak rate of 5×10−6 T⋅l/s. Initial leak testing of the vacuum chamber used conventional techniques. After final assembly, leak testing became more difficult as diagnostic systems, coil systems, and heating blankets enveloped the vacuum vessel. Methods were developed to locate and quantify vacuum leaks in this difficult environment. A residual gas analyzer was used for temporal response to gases flowed at various points outside the vessel. Leaks occurring in the primary vessel wall were measured by pumping on gas cooling channels adjacent to the primary vacuum wall. Air in these channels was also displaced by other gases at a constant rate to give location of leaks to within 50 cm. Vacuum leaks occurred during machine operations due to applied stresses, plasma‐material interactions, and diagnostic equipment failures. Machine vents to fix these leaks involve a significant loss of time, particularly in returning to clean wall conditions. Methods other than venting the vessel have been used, such as helium ’’patches,’’ if these leaks are sufficiently small.
Multihop Wireless Communications with non regenerative relays (2006)

This paper evaluates the interest of a non regenerative relay in a multihop wireless communications channels in indoor environment at 60 GHz. We develop an expression of the multipaths channel and noise at the receiver in ad hoc network and amplify-and-forward relay allows to have energy for a given signal to noise ratio (SNR) at the receiver input
The retinoic acid receptor-beta 2 contains two separate cell-specific transactivation domains, at the N-terminus and in the ligand-binding domain. (1993)

In contrast to other members of the steroid/thyroid hormone superfamily, not much is known about the regions involved in transactivation of the receptors for retinoic acid. To determine the transactivation function of RARs, fusion proteins between the DNA-binding domain of the yeast transcription factor GAL4 and retinoic acid receptor-alpha (RAR alpha) or RAR beta were made. Transfection of these constructs resulted in RA-induced activation of a GAL4-responsive element-containing promoter. Deletion analysis revealed that RAR beta-2 has two transcription activation functions (TAFs). TAF-1 activates transcription constitutively and was mapped to the first 32 amino acids of the A-region. TAF-2 is located in the ligand-binding domain between amino acids 137 and 410 and activated transcription only in the presence of RA. The presence of two TAFs was confirmed by cotransfection of RAR beta deletion constructs with the human RAR beta-2 promoter as reporter, showing that the absence of RAR beta TAF-1 causes a decrease in transactivation, whereas truncation of TAF-2 completely blocks this function. Internal deletions in the ligand-binding domain in both GAL-RAR beta and RAR beta expression constructs resulted in a nonfunctional receptor, indicating that the complete ligand-binding domain is required for its transactivation function. Furthermore, we have shown that the contribution of the two TAFs in transcription activation varies among different cell lines, suggesting that they act in a cell-specific manner.
Improving accuracy of automated 3-D building models for smart cities (2017)

Photorealistic three-dimensional (3-D) models are important tools for urban and disaster management planning because they contain useful visual and spatial information for assessing the situation and responding accordingly. Thus, it is crucial for 3-D city models to maintain a high level of accuracy in portraying 3-D geometric objects. Despite that, significant research with respect to 3-D city models has been conducted; however, it is still difficult to create accurate 3-D representations, particularly across a wide area. Thus, this research is aimed at developing an automated 3-D city modeling application that utilizes a combination of aerial photographs, terrestrial light detection and ranging, and total station techniques for particularly dense urban areas. To enable the development of an automated 3-D city model, this research developed application software programmed in C++. This application enables users to generate 3-D images of buildings. Specifically, the 3-D city models are generated using the aerial photographs. The positional accuracy of the model is highly improved by comparing building models produced using a photogrammetric plotting instrument. Once created using a combination of aerial photos and terrestrial instruments, the 3-D city model is quantitatively assessed for completeness and suitability for commercial or public use.
Game-Theoretic Patrolling with Dynamic Execution Uncertainty and a Case Study on a Real Transit System (2014)

Attacker-Defender Stackelberg security games (SSGs) have emerged as an important research area in multi-agent systems. However, existing SSGs models yield fixed, static, schedules which fail in dynamic domains where defenders face execution uncertainty, i.e., in domains where defenders may face unanticipated disruptions of their schedules. A concrete example is an application involving checking fares on trains, where a defender's schedule is frequently interrupted by fare evaders, making static schedules useless. To address this shortcoming, this paper provides four main contributions. First, we present a novel general Bayesian Stackelberg game model for security resource allocation in dynamic uncertain domains. In this new model, execution uncertainty is handled by using a Markov decision process (MDP) for generating defender policies. Second, we study the problem of computing a Stackelberg equilibrium for this game and exploit problem structure to reduce it to a polynomial-sized optimization problem. Shifting to evaluation, our third contribution shows, in simulation, that our MDP-based policies overcome the failures of previous SSG algorithms. In so doing, we can now build a complete system, that enables handling of schedule interruptions and, consequently, to conduct some of the first controlled experiments on SSGs in the field. Hence, as our final contribution, we present results from a real-world experiment on Metro trains in Los Angeles validating our MDP-based model, and most importantly, concretely measuring the benefits of SSGs for security resource allocation.
The Eighth FIII Domain of Human Fibronectin Promotes Integrin α5β1 Binding via Stabilization of the Ninth FIII Domain (2001)

Binding of the extracellular matrix molecule fibronectin to the integrin receptor alpha(5)beta(1) elicits downstream signaling pathways that modulate cell function. Fibronectin-alpha(5)beta(1) interaction occurs via the conserved RGD sequence in the tenth FIII (FIII10) domain of fibronectin. A synergistic site containing the sequence PHSRN in the adjacent FIII9 domain has also been identified. Here we investigate the function of the eighth FIII domain in integrin-mediated cell adhesion using a wide range of methods, including biochemical, biological, and biophysical assays of integrin binding, cell adhesion, and protein denaturation. Mutation of the FIII9 synergistic site (PHSRN to PHAAA) in FIII9-10 reduced the binding activity for integrin alpha(5)beta(1) to levels observed for FIII10 alone, but the corresponding mutant in FIII8-9-10 showed no loss of binding activity. Cell adhesion assays also demonstrated enhanced functional activity of constructs containing FIII8. Equilibrium chemical denaturation studies indicated that FIII8 confers conformational stability upon FIII9, but only if the exposed loops, PHSRN and VKNEED on FIII9 and FIII8, respectively, are intact. These results demonstrate that the loss of integrin binding activity, observed upon alteration of the PHSRN synergistic site of FIII9-10, results partly from a loss of conformational stability of FIII9. Our data suggest a mechanism for integrin alpha(5)beta(1)-fibronectin interaction, which in addition to the primary RGD binding event, involves a conformation-sensitive scanning by the integrin for accessible sites on the ligand, whereupon full activation of downstream signaling occurs.