gebhart/patrepeval huggingface dataset:
DAB389IL2 diphtheria fusion toxin produces clinical responses in tumor stage cutaneous T cell lymphoma (1998)

Four patients with late stage cutaneous T cell lymphoma (IB-IVA) who had failed at least two previous therapies were treated with DAB389IL2 at 9 or 18 microg/kg as 15-min intravenous infusions daily for 5 days every 3 weeks for eight cycles. Mild vascular leak syndrome (VLS) with transient edema, hypoalbuminemia, weight gain, and myalgias was observed in two of the patients lasting 7-10 days and only occurring on the first cycle. One stage IB patient had a pathologic complete remission (CR) lasting 11+ months from treatment initiation, one stage IIB patient had a complete clinical remission (CCR) lasting >6 months with complete clearing of a large tumor lasting >18 months, and one stage IIB and the one stage IVA patient had partial remissions (80-99% reduction in tumor masses) lasting 5 months. While IL2 receptor (IL2R) was expressed on 20-50% of tumor cells prior to therapy, recurrent tumor was IL2R negative in three of the patients. DAB389IL2 at tolerable doses decreased tumor burden in each of these four standard treatment refractory CTCL patients and may offer an important alternative to standard palliative chemotherapy regimens.
Additive and Multiplicative Noise Reduction by Back Propagation Neural Network (2007)

A novel filter is proposed by applying back propagation neural network (BPNN) ensemble where the noisy signal and the reference one are the same. The neural network(NN) ensemble filter not only well reduces additive and multiplicative white noise inside signals, but also preserves signals' characteristics. It is proved that while power of noise is larger, the reduction of noise using NN ensemble filter is better than the improved ¿ nonlinear filter and single NN filter, and compared with the improved ¿ nonlinear filter, degradation o the capability for reduction of noise by NN ensemble due to the increase of noise power is much suppressed. Furthermore, it is presented of the relationship between noise reduction and bandwidth of noises. The performance of the NN ensemble filter is demonstrated in computer simulations and actual electroencephalogram (EEG) signals processing.
Teaching the Skills of Interpreting Pictorial Material (1953)

Journal Article Teaching the Skills of Interpreting Pictorial Material Get access Russel H. Fowler Russel H. Fowler 1Communication Skills Division, Stephens College, Columbia, Missouri Search for other works by this author on: Oxford Academic Google Scholar Journal of Communication, Volume 3, Issue 2, November 1953, Pages 77–80, https://doi.org/10.1111/j.1460-2466.1953.tb01077.x Published: 07 February 2006
Practical Energy Harvesting for Batteryless Ambient Backscatter Sensors (2018)

This work studies the performance of two methods for providing power to an ultra-low power, ambient backscatter tag, omitting the need for any battery. RF energy harvesting from a dedicated source and energy harvesting from ambient light using a single photodiode are compared. Extensive measurement results from tests conducted under real world conditions are offered for both harvesting methods. It is concluded that for a total cost of under 7 Euros the need for a battery can be eliminated, by using a single photodiode element along with a suitable boost converter. The ultra-low power character of the utilized tag enables the use of multiple harvesting methods and paves the way towards truly battery-less wireless sensor systems.
The Holographic Honeycomb Microlens (1985)

A honeycomb close-packed microstructure can be recorded in a positive photoresist layer by a simultaneous exposure of three coherent laser beams. The structure consists of parabolic shaped depressions in the surface. By replication and embossing techniques, it is possible to impress the mirror image of the microstructure into plastic, such that the top surface consists of parabolic shaped posts, or microlenses. The size of each microlens can be varied from around one micrometer to a millimeter or more. There are wide-ranging applications for such regularly-spaced and precise structures, extending from solar concentrators to three-dimensional imaging devices.
A novel technique for optimal efficiency control of a current-source inverter-fed induction motor (1988)

A technique that optimizes flux level to improve the efficiency of an induction motor is discussed. When harmonics and saturation effects are considered, the slip of minimum loss, or optimal slip, depends on both the speed and the load torque. The measurements of speed and torque are achieved without conventional torque and speed sensors, using motor terminal quantities. The control strategy is divided into two stages. First, the optimal slip is searched by trial and error, and the results are tabulated in microprocessor memory. Then the motor is operated at optimal efficiency by simply tracking the optimal slip given in the table. Experimental results show good performance in energy saving and dynamic responses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Thermal radiation from two-dimensionally confined modes in microcavities (2001)

A two-dimensional array of a microcavity with a high aspect ratio is made on a Cr-coated Si surface using the micromachining technology. The thermal emission spectra whose wavelength is close to the dimension of cavity aperture (5 μm) are measured on samples with a different aspect ratio. The clear selective emission bands corresponding to the two-dimensionally confined electromagnetic modes are demonstrated experimentally. It is found that the low emissivity of the base material is essential to obtain the high spectral selectivity of thermal radiation. The direction and polarization properties are also examined. The dominant peaks of the emission spectra can be explained by a simple cavity resonator model.
Batch solvent extraction of flavanolignans from milk thistle (<i>Silybum marianum</i> L. Gaertner) (2005)

Seeds of milk thistle (Silybum marianum L. Gaertner) contain silymarins and ca. 25% (w/w) of oil. A pre-treatment step involving refluxing with petroleum ether is usually performed before extraction of the silymarins using organic solvents. This paper compares the extraction of whole and defatted milk thistle seeds in various solvents as a function of temperature. The extraction of whole seeds of milk thistle with water at 50, 70 and 85 degrees C was also examined: the yield of silymarin increased with increasing water temperature. In most cases, ethanol at 60 degrees C recovered the largest quantities of silymarins. However, boiling water proved to be an efficient extraction solvent for the more polar silymarins such as taxifolin and silychristin, even when using whole seeds. Extractions of defatted seed meal with boiling ethanol returned maximum yields of 0.62, 3.89, 4.04, and 6.86 mg/g defatted seed of taxifolin, silychristin, silybinin A and silybinin B, respectively. When extracting defatted seed meal with ethanol, yields of taxifolin, silybinin A and silybinin B were, respectively, 6.8-, 0.95-, 1.7- and 1.6-fold higher than when extracting whole seeds. When extracting with boiling water, the yields of silychristin, silybinin A, and silybinin B were 380, 47 and 50% higher for whole seeds compared with defatted seeds.
Intercalary Flexor Tendon Grafts:<i>A Morphological Study of Intrasynovial and Extrasynovial Donor Tendons</i> (1992)

Intercalary intrasynovial and extrasynovial flexor tendon graft donors were placed within the synovial sheaths of the medial and lateral forepaw digits of 22 dogs and treated with early controlled passive mobilization. Specimens were studied by light and transmission electron microscopy at 10 and 21 days. Early repair in the extrasynovial tendons occurred by an ingrowth of connective tissue from the digital sheath. Adhesions obliterated the gliding surface and occupied the space between the tendon's gliding surface and surrounding tissues. There was no epitenon response noted in the extrasynovial tendon grafts. While there was considerable new collagen fibril formation within the repair site at the ultrastructural level, there was a lack of longitudinal remodeling. In contrast, the intrasynovial tendon grafts showed early healing, with minimal adhesion formation, by a proliferation and migration of cells from the epitenon. These cells showed greater cellular activity and collagen production at 10 and 21 days compared to cells in extrasynovial tendons at the same intervals. The findings of this study suggest that the use of intrasynovial autogenous tendon graft donors, coupled with early controlled motion, stimulates an intrinsic repair process in both the tendon stump and autogeneous tendon graft. These findings differ significantly from the experimental findings in which extrasynovial, paratenon-covered grafts are used.
Valerian-Hops Combination and Diphenhydramine for Treating Insomnia: A Randomized Placebo-Controlled Clinical Trial (2005)

The findings show a modest hypnotic effect for a valerian-hops combination and diphenhydramine relative to placebo. Sleep improvements with a valerian-hops combination are associated with improved quality of life. Both treatments appear safe and did not produce rebound insomnia upon discontinuation during this study. Overall, these findings indicate that a valerian-hops combination and diphenhydramine might be useful adjuncts in the treatment of mild insomnia.
2,8′-Disubstituted-1,1′-Binaphthyls: A New Pattern in Chiral Ligands (2002)

The title binaphthyls 19 and 26, which are the positional isomers of 2-methoxy-2'-(diphenylphosphino)-1,1'-binaphthyl (MOP, 19) and 2-amino-2'-hydroxy-1,1'-binaphthyl (NOBIN, 26), have been synthesized by Suzuki coupling as the key step (10 + 15-->18), followed by functional group transformations, involving C-P and C-N bond formation (18-->19 and 18-->23). Racemic intermediate 22 was resolved by co-crystallization with N-benzylcinchonidinium chloride and the absolute configuration determined by X-ray crystallography. These novel binaphthyls are configurationally stable and, as such, potentially usable as chiral ligands in asymmetric reactions. Michael addition of the glycine-derived enolate 40 to methyl acrylate, carried out in the presence of (R)-(-)-27 as the chiral phase-transfer catalyst, afforded L-glutamic acid (S)-(+)-43 of 92% ee (after hydrolysis of the primary product).
Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells (2016)

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Pterostilbene, a natural dimethylated analog of resveratrol, has been shown to possess diverse pharmacological activities, including anti-inflammatory, antioxidant and anticancer properties. However, to the best of our knowledge, there has been no study of the effects of pterostilbene upon hematological malignancies. Herein, we report the antitumor activity and mechanism of pterostilbene against DLBCL cells both in vitro and in vivo. We found that pterostilbene treatment resulted in a dose-dependent inhibition of cell viability. In addition, pterostilbene exhibited a strong cytotoxic effect, as evidenced not only by reductions of mitochondrial membrane potential (MMP) but also by increases in cellular apoptotic index and reactive oxygen species (ROS) levels, leading to arrest in the S-phase of the cell cycle. Furthermore, pterostilbene treatment directly up-regulated p-p38MAPK and down-regulated p-ERK1/2. In vivo, intravenous administration of pterostilbene inhibited tumor development in xenograft mouse models. Overall, the results suggested that pterostilbene is a potential anti-cancer pharmaceutical against human DLBCL by a mechanism involving the suppression of ERK1/2 and activation of p38MAPK signaling pathways.
Freezing Molecular Orientation under Stretch for High Mechanical Strength but Anisotropic Hydrogels (2016)

The poor mechanical strength of hydrogels has largely limited their wide applications, and improving hydrogels' mechanical strength is a hot and important topic in the hydrogel research field. Although many successful strategies have been proposed to improve hydrogels' mechanical strength during the past decades, a hydrogel with a tensile stress surpassing dozens of mega Pascal is desirable, yet still a big challenge. To address this issue, the Fe(3+) -mediated physical crosslinking formed under stretch conditions was employed in a chemically crosslinked poly (acrylamide-co-acrylic acid) network to achieve a dual-crosslinked hydrogel. The expected molecular orientation occurs under stretch and allows the maximumu chelating interaction between pendant carboxylic anions and Fe(3+) and molecules conformation being frozen, leading to the mechanical strength improving dramatically. As a result, an unprecedentedly high mechanical strength, but anisotropic dual-crosslinked hydrogel was obtained. By optimizing the experimental parameters, the nominal tensile stress along pre-stretching direction can reach as high as ≈40 MPa with elastic modulus of ≈40 MPa at large strain (>200%). In addition, the molecular orientation also leads to big difference of mechanical performance between parallel and perpendicular direction.
Electronic absorption spectroscopy of jet-cooled molecules (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic absorption spectroscopy of jet-cooled moleculesVeronica VaidaCite this: Acc. Chem. Res. 1986, 19, 4, 114–120Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ar00124a003https://doi.org/10.1021/ar00124a003research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dietary Protein Restriction Lowers Plasma Insulin-Like Growth Factor I (IGF-I), Impairs Cortical Bone Formation, and Induces Osteoblastic Resistance to IGF-I in Adult Female Rats (2000)

Dietary protein deficiency, common in elderly, is associated with decreased areal bone mineral density and plasma insulin-like growth factor I (IGF-I). To investigate the early adaptation of bone cells to protein restriction, 6-month-old female rats were pair-fed with isocaloric 15% (control) or 2.5% casein diets for 14 days. Animals were then treated daily with rhIGF-I/IGFBP-3 (1:4, 2.5 mg IGF-I/kg BW) or with vehicle for 10 days. After double-labeling, proximal metaphysis and mid-diaphysis of the tibia were analyzed histomorphometrically. Plasma osteocalcin, IGF-I, and urinary deoxypyridinoline were quantified. After 14 days of protein restriction, significant drops in plasma osteocalcin (13%) and IGF-I (37%), in periosteal formation (83%) and mineral apposition (49%) rates are observed, indicating a
A robust approach to the permutation problem of frequency-domain blind source separation (2004)

This paper presents a robust and precise method for solving the permutation problem of frequency-domain blind source separation. It is based on two previous approaches: the direction of arrival estimation approach and the inter-frequency correlation approach. We discuss the advantages and disadvantages of the two approaches, and integrate them to exploit the both advantages. We also present a closed form formula to calculate a null direction, which is used in estimating the directions of source signals. Experimental results show that our method solved permutation problems almost perfectly for a situation that two sources were mixed in a room whose reverberation time was 300 ms.
Geographic aspects concerning amelioration of the soils degradation in the district of Timis (1973)

Timisoara, Romania
Alfred Magazine, April 2006 (2012)

In each issue of The Alfred Magazine, in each story we tell at Reunion, in each email we write to our classmates, there's an underlying theme: The strength of Alfred connections that tie us to each other.I, like so many Alfred alumni, have stories that characterize my own unique set of Alfred connections.Whether it be how I came to choose Alfred University in my senior year of high school, my representing AU last October at a presidential inauguration in Virginia, or hearing about others' AU connections while on business at the University of Richmond in late January of this year.A personal AU Connection: As a senior in high school I had not even heard of Alfred let alone considered applying for admission.A long-time family friend and personal mentor of mine, Dr
Electrooptic Inspection of Vector Leakage in Radiofrequency Multichip Modules (2013)

This paper demonstrates a new approach for the measurement of vector electromagnetic leakage within tightly integrated electronic subsystems. Specifically, the effect of shielding and encapsulation techniques commonly used in radiofrequency (RF) multichip modules is investigated using an electrooptic (EO) near-field measurement system. The test vehicle used for this study is a single-chip 50-W microwave power amplifier integrated into a multilayer low-temperature cofired ceramic module. The measured near-field data show power intensity at 2.5 GHz with up to 0.2-mm resolution for each of the three x-, y-, and z-directed electric field vectors. The resulting images illustrate 1) the polarization-dependent shortcomings of the ubiquitous “via-fence” shielding technique and 2) the formation of surface waves in microstrip substrates due to impedance mismatch. These results are evidence of the applicability of the EO technique to the diagnosis of electromagnetic compatibility issues within compact RF multichip modules.
Fabrication of Honeycomb Film of an Amphiphilic Copolymer at the Air−Water Interface (2002)

We report a new fabrication method of a thin polymer film with regular array of micropores (honeycomb film). A honeycomb film was fabricated by depositing a dilute solution of an amphiphilic polymer on water surface. The honeycomb film transferred onto a solid substrate was characterized by atomic force microscopy. By this fabrication method, it was possible to control film area, pore diameter, and film thickness. The pore size depended upon the evaporation time of the polymer solution spread on water surface. The thickness of a honeycomb film was controlled by spreading area of the polymer solution. The spreading behavior was influenced by the water temperature. The film area was proportional to the volume of spread polymer solution and controlled by changing the sub-phase temperature, too. When the polymer solution was simply cast on a solid substrate, a thin polymer layer remained in the bottom of the honeycomb pores. On the other hand, the honeycomb film fabricated on water surface has no bottom layer in its pores. A self-standing honeycomb mesh is formed by the “on-water spreading” method.
Synthesis of conjugated trienoic fatty acids by a cell‐free preparation of tung endosperm (1972)

Abstract An acetone‐insoluble fraction that catalyzes the synthesis of conjugated trienoic fatty acid was prepared from maturing tung nuts. Greatest synthesis with the enzymic fraction occurred in the presence of CoASH, NADH and either ATP or ADP.
Genetic Alterations in Childhood Medulloblastoma Analyzed by Comparative Genomic Hybridization (2002)

Despite intensive therapy, the survival of children with medulloblastoma remains disappointing. Moreover, children who survive are affected by serious long-term sequelae of treatment that impair their quality of life. In search of chromosomal aberrations indicative of sites involved in oncogenic transformation and in an attempt to find reliable prognostic markers, the authors analyzed 15 medulloblastomas by comparative genomic hybridization. All neoplasms showed chromosomal abnormalities. The most frequent losses were 17p (7/15 tumors), 8p and 11p (6/15), 10p, 1lq, 16q, and 20q (5/15), and 20p (4/15). Gains were recurrently found at 7q (10/15 tumors), 17q and 18q (9/15 tumors), 7p and 13q (7/15), 18p (6/15), and 1q, 4q, 6q. and 9p (5/15 tumors). Four tumors showed loss of 17p together with gain of 17q, suggesting an isochromosome 17q. High-level amplifications were seen at 1p34, 5p15, 13q34, and 18p11 (one tumor each), and at 2p15 in two tumors, one of which was proven to be N-Myc amplification. The overall pattern of alterations found in this study confirms the findings of other studies and adds two novel regions with chromosomal gains, at 13q and 18q. Previous reports on the relation between 17q gain and survival could not be confirmed, whereas amplification of N-myc or L-myc seems to indicate poor clinical outcome.
Control Channel Design for Many-Antenna MU-MIMO (2015)

Many-antenna MU-MIMO faces a critical, previously unaddressed challenge: it lacks a practical control channel. At the heart of this challenge is that the potential range of MU-MIMO beamforming systems scales with up to the square of the number of base-station antennas once they have channel state information (CSI), whereas the range of traditional control channel operations remains constant since they take place before or during CSI acquisition. This range gap between no-CSI and CSI modes presents a critical challenge to the efficiency and feasibility of many-antenna base stations, as their operational range is limited to the no-CSI mode. We present a novel control channel design for many-antenna MU-MIMO, Faros, that allows the number of base-station antennas to scale up to 100s in practice. Faros leverages a combination of open-loop beamforming and coding gains to bridge the range gap between the CSI and no-CSI modes. Not only does Faros provide an elegant and efficient control channel for many-antenna MU-MIMO, but on a more fundamental level it exposes flexible, fine-grained, control over space, time, and code resources, which enables previously impossible optimizations. We implement our design on the Argos many-antenna base station and evaluate its performance in bridging the range gap, synchronization, and paging. With 108 antennas, Faros can provide over 40 dB of gain, which enables it to function reliably at over 250 meters outdoors with less than 100 μW of transmit power per antenna, 10 mW total, at 2.4 GHz.
Plowing: Interactive Stretching and Compaction in Magic (1984)

The Magic layout editor provides a new operation called plowing, for stretching and compacting Manhattan VLSI layouts. Plowing works directly on the mask-level representation of a layout, allowing portions of it to be rearranged while preserving connectivity and layout-rule correctness. The layout and connectivity rules are read from a file, so plowing is technology independent. Plowing is fast enough to be used interactively. This paper presents the plowing operation and the algorithm used to implement it.