gebhart/patrepeval huggingface dataset:
<title>Modulated laser line scanner for enhanced underwater imaging</title> (1999)

Current Laser Line Scanner (LLS) sensor performance is limited in turbid water and in bright solar background conditions. In turbid water, backscattered and small angle forward scattered light reaching the receiver decreases underwater target contrast and resolution. Scattered solar energy reaching the detector also decreases detection sensitivity by increasing receiver noise. Thus, a technique which rejects unwanted, scattered light while retaining image-bearing photons is needed to improve underwater object detection and identification. The approach which we are investigating is the application of radar modulation and detection techniques to the LLS. This configuration will enable us to use optical modulation to discriminate against scattered light. A nonscanning mock-up of an existing LLS, the Electro-Optic Identification sensor, has been developed with off-the-shelf components. An electro-optic modulator will be added to this system to create a modulated LLS prototype. Laboratory tank experiments will be conducted to evaluate the performance of the modulated LLS as a function of water clarity and solar background levels. The new system will be compared to its unmodulated counterpart in terms of target contrast.
Evolution of a compound droplet attached to a core-shell nozzle under the action of a strong electric field (2006)

The shape evolution of small compound droplets at the exit of a core-shell system in the presence of a sufficiently strong electric field is studied both experimentally and theoretically. It is shown that the jetting effect at the tip of the shell nozzle does not necessarily cause entrainment of the core fluid, in which case the co-electrospinning process fails to produce core-shell nanofibers. The remedy lies in extending the core nozzle outside its shell counterpart by about half the radius of the latter. The results also show that the free charges migrate very rapidly from both fluids and their interface to the free surface of the shell. This reflects the fact that most of the prejetting evolution of the droplet can be effectively described in terms of the perfect conductor model, even though the fluids can be characterized as leaky dielectrics. The stress level at the core-shell interface is of the order of 5×103g∕(cms2), the relevant value in assessing the viability of viruses, bacteria, DNA molecules, drugs, enzymes, chromophores, and proteins to be encapsulated in nanofibers via co-electrospinning.
Energy Expenditure and Physical Activity in Recovering Malnourished Infants (2009)

Background. Malnourished infants are small for age and weight. Objectives. Determine profiles in 24-hour energy metabolism in recovering malnourished infants and compare to similarly aged healthy controls. Methods. 10 malnourished infants (58.1 +/- 5.9 cm, 7.7 +/- 5.6 months) were healthy prior to spending 22 hours in the Enhanced Metabolic Testing Activity Chamber for measurement of EE (kcal/min), sleeping metabolic rate (SMR; kcal/min), respiratory quotient (RQ; VCO(2)/VO(2)), and physical activity (PA; oscillations in wt/min/kg body weight). Metabolic data were extrapolated to 24 hours (kcal/kg/d). Energy intake (kcal/kg/d) and the proportions (%) of carbohydrate, protein, and fat were calculated. Anthropometrics for malnourished infants were obtained. Statistical differences (P < .05) between groups were determined (SPSS, version 13). Results. In comparison to controls, malnourished infants were lighter (4.1 +/- 1.2 versus 7.3 +/- 0.8 kg; P < .05), had less body fat % (10.3 +/- 7.6 versus 25.7 +/- 2.5), and lower BMI (12.0 +/- 1.7 versus 15.5 +/- 1.5; P < .05). In contrast, they had greater energy intake (142.7 +/- 14.6 versus 85.1 +/- 25.8; P < .05) with a greater percentage of carbohydrates (55.1 +/- 3.9 versus 47.2 +/- 5.2; P < .05). However, malnourished infants had greater 24-hour EE (101.3 +/- 20.1 versus 78.6 +/- 8.4; P < .05), SMR (92.6 +/- 17.1 versus 65.0 +/- 3.9; P < .05), and RQ (1.00 +/- 0.13 versus 0.86 +/- 0.08; P < .05) along with a lower amount of PA (2.3 +/- 0.94 versus 4.0 +/- 1.5; P < .05). Conclusions. Malnourished infants require more energy, possibly for growth.
Diclofenac attenuates Wnt/β‐catenin signaling in colon cancer cells by activation of NF‐κB (2005)

The dysregulation of Wnt/beta-catenin signaling and subsequent upregulation of beta-catenin response transcription (CRT) occur frequently in colon cancer cells. Non-steroidal anti-inflammatory drugs (NSAIDs) can repress CRT in colorectal cancer, but little is known about the mechanism of action. We show that the NSAID diclofenac inhibits Wnt/beta-catenin signaling without altering the level of beta-catenin protein and reduces the expression of beta-catenin/TCF-dependent genes. Diclofenac induced the degradation of IkappaBalpha, which increased free nuclear factor kappaB (NF-kappaB) in cells. Also, the ectopic expression of p65, which is a component of NF-kappaB, suppressed CRT. Our findings suggest that diclofenac inhibits Wnt/beta-catenin signaling via the activation of NF-kappaB in colon cancer cells.
Catalysis by diamonds and other forms of carbon (1996)

Some activated carbons and carbon blacks are known to be good catalysts for a variety of liquid phase reactions such as selective carbon-carbon cleavage and dehalogenation of halogenated hydrocarbons. We will present data on the catalytic activity of well characterized, relatively simple forms of carbons such as diamonds and diamond-graphite composites. Both industrial and natural diamonds have been used. TEM provided detailed information on the nature of the carbons at the surface of the carbon materials used as catalysts. Clean surfaces of natural diamond particles are active catalysts in reactions such as debromination of 1-Br-naphthalene and 1-Br-adamantane.
ChemInform Abstract: REACTIONS OF PHTHALALDEHYDE WITH AMMONIA AND AMINES (1978)

Abstract Phthalaldehyd (II) reagiert mit Wasser reversibel zu einem Hydrat (I).
Sequence of horse pancreatic lipase as determined by protein and cDNA sequencing (1992)

The complete sequence of the horse pancreatic lipase was elucidated by combining polypeptide chain and cDNA sequencing. Among the structural features of horse lipase, it is worth mentioning that Lys373 is not conserved. This residue, which is present in human, porcine and canine lipases, has been assumed to be involved in p-nitrophenyl acetate hydrolysis by pancreatic lipases. Kinetic investigation of the p-nitrophenyl acetate hydrolysis by the various pancreatic lipases and by the C-terminal domain (336-449) of human lipase reveals that this hydrolysis is the result of the superimposition of independent events; a specific linear hydrolysis occurring at the active site of lipase, a fast acylation depending on the presence of Lys373 and a non-specific hydrolysis most likely occurring in the C-terminal domain of the enzyme. This finding definitely proves that pancreatic lipase bears only one active site and raises the question of a covalent catalysis by pancreatic lipases. Moreover, based on sequence comparison with the above-mentioned pancreatic lipases, three residues located in the C-terminal domain, Lys349, Lys398 and Lys419, are proposed as possible candidates for lipase/colipase binding.
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells (2012)

Lymphoid tissue development is initiated during embryogenesis by the migration of lymphoid tissue inducer (LTi) cells from the fetal liver to the periphery, where they induce the formation of lymph nodes and Peyer's patches. In the fetal liver, a subset of common lymphoid progenitors (CLPs) that expresses the integrin α4β7 gives rise to LTi cells, a process strictly dependent on the expression of the transcriptional repressor Id2 and the nuclear hormone receptor retinoic acid-related orphan receptor γ t (RORγt). In this study, we show that Id2 and RORγt are sequentially up-regulated during LTi cell development, matching two waves of differentiation with opposite requirements for Notch signaling. Both the expression of Id2 and Notch are required for the generation of α4β7(+) RORγt(-) fetal progenitors, but Notch subsequently blocks progression to the RORγt(+) stage and final maturation of LTi cells. Notch is therefore a necessary switch to engage the LTi developmental pathway, but needs to be turned off later to avoid diversion to the T cell fate.
Targeted gene inactivation in <i>Clostridium phytofermentans</i> shows that cellulose degradation requires the family 9 hydrolase Cphy3367 (2009)

Summary Microbial cellulose degradation is a central part of the global carbon cycle and has great potential for the development of inexpensive, carbon-neutral biofuels from non-food crops. Clostridium phytofermentans has a repertoire of 108 putative glycoside hydrolases to break down cellulose and hemicellulose into sugars, which this organism then ferments primarily to ethanol. An understanding of cellulose degradation at the molecular level requires learning the different roles of these hydrolases. In this study, we show that interspecific conjugation with Escherichia coli can be used to transfer a plasmid into C. phytofermentans that has a resistance marker, an origin of replication that can be selectively lost, and a designed group II intron for efficient, targeted chromosomal insertions without selection. We applied these methods to disrupt the cphy3367 gene, which encodes the sole family 9 glycoside hydrolase (GH9) in the C. phytofermentans genome. The GH9-deficient strain grew normally on some carbon sources such as glucose, but had lost the ability to degrade cellulose. Although C. phytofermentans upregulates the expression of numerous enzymes to break down cellulose, this process thus relies upon a single, key hydrolase, Cphy3367.
Glucocorticoid activity and structure activity relationships in a series of some novel 17 alpha-ether-substituted steroids: influence of 17 alpha-substituents. (1991)

A series of non-fluorinated glucocorticoids, cortienic acid analogs with a 17 beta-chloromethyl ester and various 17 alpha-ether functions, were tested for their affinity to the rat-lung type-II glucocorticoid receptor. The relative binding affinity of a set of 9 compounds was determined in a competitive experiment with [1,2,4-3H]triamcinolone acetonide. The highest binding affinities were observed with the 17 alpha-propoxy and butoxy analogs which were 1.3 times more active than the standard dexamethasone. Quantitative analysis of the results suggested that steric factors and lipophilicity of the side-chain were the major parameters affecting receptor affinity. Representative members of the series were compared to betamethasone 17 alpha-valerate in a vasonstriction test. The results paralleled those of the receptor binding experiment, indicating that the new steroids have good skin-permeation properties and good glucocorticoid activity.
Wavelength-division multi demultiplexers for two-channel single-mode transmission systems (1984)

Low-loss lensless 2-channel wavelength-division multiplexing (WDM) couplers may be produced on the beam-splitter principle with interference filters and three butt-coupled fiber ends not only for multi-mode Operation but also for single-mode transmission links. These devices are constructed with single-mode fibers-for bidirectional transmission only in the transmission channel, but for unidirectional operation in all channels. The interference filter, used in the experiment to separate the emissions of two LD's with wavelengths of 834 and 868 nm, may be implemented both as a longwave-pass (LWP) and a shortwave-pass (SWP) edge filter with high edge steepness and low polarization effects. WDM single-mode couplers exhibit very low insertion losses lying in the O.5-dB region. Their fat-end crosstalk attenuations attain values of between 15 and 30 dB and their near-end crosstalk attenuations are better than 65 dB.
Tension-type headaches. (1993)

Tension-type headaches are generally characterized by slowly progressive, dull, constant, nonpulsatile pain in the occipital and posterior neck or in a "headband" distribution. Episodic tension-type headaches occur fewer than 15 times a month, and chronic tension-type headaches occur more than 15 times a month for at least six months. Cranial radiography, computed tomographic scanning, electroencephalography and other adjunctive tests are unnecessary if the presentation is typical and the headache is not associated with seizure activity, mental status changes, neurologic deficits and other markers of potentially serious underlying disease. Treatment of episodic tension-type headaches may include topical heat or cold packs, exercise and other stress-reduction techniques, mild analgesics, muscle relaxants and trigger-point injections. Some patients may benefit from antidepressants and individual or family counseling.
Fieldbus in the process control laboratory-its time has come (2003)

Industrial process control has evolved following the path of direct digital control (DDC-1962), programmable logic controllers (PLC-1972), distributed control systems (DCS-1976), and field control systems (FCS-1994). The latest field control system evolution that is taking place is the implementation of Foundation fieldbus (FF) into the manufacturing environment. This article describes Foundation Fieldbus, its role in a plant network hierarchy, and a comparison between Foundation Fieldbus and the older DCS model. In addition, this article discusses instructional issues associated with teaching Foundation Fieldbus in a system control course and laboratory, along with an overview of the hardware and software necessary to build a network of Foundation Fieldbus devices through integration of FF on existing process trainers.
Sugar beet (Beta vulgaris L.) morphogenesis in vitro: Effects of phytohormone type and concentration in the culture medium, type of explants, and plant genotype on shoot regeneration frequency (2006)

In vitro regeneration techniques have been optimized for seven strains and cultivars of sugar beet (Beta vulgaris L.) bred in Russia. The frequency of shoot regeneration from somatic cells and tissues of sugar beet varies from 10 to 97% depending on the explant type, culture-medium composition, and genotype. The in vitro regeneration potential has been estimated in plants with different genotypes. The effect of medium composition (phytohormones and carbohydrates) on the frequency of the formation of a morphogenic callus competent for plant regeneration has been determined. The effect of the types and concentrations of various cytokines (zeatin, kinetin, and 6-benzylaminopurine) on direct shoot regeneration from cotyledon nodes has been estimated. The culture-medium composition has been optimized for direct shoot regeneration from petioles. The effects of different concentrations of abscisic acid on the frequency of shoot regeneration from a morphogenic callus has been studied. Micropropagation has been used to obtain petiole explants and reproduce the shoots obtained by direct regeneration from cotyledon nodes, petioles, and calluses. Improved shoot-regeneration methods can be used for both agrobacterial and bioballistic genetic transformation of the sugar beet genotypes studied.
Chitosan, Carbon Quantum Dot, and Silica Nanoparticle Mediated dsRNA Delivery for Gene Silencing in <i>Aedes aegypti</i>: A Comparative Analysis (2015)

In spite of devastating impact of mosquito borne pathogens on humans, widespread resistance to chemical insecticides and environmental concerns from residual toxicity limit mosquito control strategies. We tested three nanoparticles, chitosan, carbon quantum dot (CQD), and silica complexed with dsRNA, to target two mosquito genes (SNF7 and SRC) for controlling Aedes aegypti larvae. Relative mRNA levels were quantified using qRT-PCR to evaluate knockdown efficiency in nanoparticle-dsRNA treated larvae. The knockdown efficiency of target genes correlated with dsRNA mediated larval mortality. Among the three nanoparticles tested, CQD was the most efficient carrier for dsRNA retention, delivery, and thereby causing gene silencing and mortality in Ae. aegypti.
MT effects and <i>T</i><sub>1</sub> quantification in single‐slice spoiled gradient echo imaging (2008)

We investigated magnetization transfer (MT) effects on the steady-state MR signal for a sample subjected to a series of identical on-resonance RF pulses, such as would be experienced while imaging a single slice using a spoiled gradient echo sequence. The MT coupling terms for a two-pool system were added to the Bloch equations and we derived the resulting steady-state signal equation and compared this result to the conventional signal equation without MT effects. The steady-state signal is increased by a few percent of the equilibrium magnetization because of MT. One consequence of this MT effect is inaccuracy in T(1) values determined via conventional steady-state gradient echo methods. (Theory predicts greater than 10% errors in T(1) for white matter when using short TR.) A second consequence is the ability to quantify the relaxation and MT parameters by fitting the gradient echo steady state signal to the signal equation appropriately modified to include MT effects. The theory was tested in samples of MnCl(2), cross-linked bovine serum albumin (BSA), and cross-linked BSA + MnCl(2).
Reproductive Failure in Populations of the Dog-Whelk, <i>Nucella Lapillus</i>, Caused by Imposex Induced by Tributyltin from Antifouling Paints (1986)

The development of male characters, notably a penis and a vas deferens, on the female (the phenomenon of ‘imposex’) of the dog-whelk, Nucella lapillus , is described. Three stages are recognized: an ‘early’ stage involving the formation of a vas deferens and a small penis, an ‘intermediate’ stage characterized by the enlargement of the female penis to a size approaching that of the male and a ‘late’ stage during which the female opening (vulva) is occluded by overgrowth of vas deferens tissue. This blockage of the pallial oviduct prevents the release of egg capsules and renders the female sterile. The extent and cause of such reproductive failure is evident from the high incidence of females containing aborted capsules in declining populations close to sources of tributyltin (TBT) contamination. These same populations comprise fewer females than expected and it would appear that the accumulation of aborted capsules within the pallial oviduct eventually causes the premature death of the female.
The Effects of Wafer Thermal History on the 450°C Thermal Donor Formation in Cz- Grown P(100) Silicon (1984)

The rate and concentration of thermal donors generated during 450°C anneals were observed to be dependent on wafer thermal history. Oxygen thermal donors formed by the silicon-vacancy and silicon interstitial models were examined and the silicon-interstitial donor formation was observed to be the dominating mechanism for the 450°C oxygen thermal donor. Thermally induced microdefects were also observed. Depending on the wafer thermal history less than 1 × 1014 donors/cm3 to as much as 3.7 × 1014 donors/cm3 were formed during the 450°C anneals.
DERIVATIVES OF DULCIN (1931)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDERIVATIVES OF DULCINE. WertheimCite this: J. Am. Chem. Soc. 1931, 53, 1, 200–203Publication Date (Print):January 1, 1931Publication History Published online1 May 2002Published inissue 1 January 1931https://pubs.acs.org/doi/10.1021/ja01352a026https://doi.org/10.1021/ja01352a026research-articleACS PublicationsRequest reuse permissionsArticle Views211Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
EW-7197, a Novel ALK-5 Kinase Inhibitor, Potently Inhibits Breast to Lung Metastasis (2014)

Advanced tumors produce an excessive amount of transforming growth factor β (TGFβ), which promotes tumor progression at late stages of malignancy. The purpose of this study was to develop anti-TGFβ therapeutics for cancer. We synthesized a novel small-molecule TGFβ receptor I kinase (activin receptor-like kinase 5) inhibitor termed N-[[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline (EW-7197), and we investigated its potential antimetastatic efficacy in mouse mammary tumor virus (MMTV)/c-Neu mice and 4T1 orthotopic-grafted mice. EW-7197 inhibited Smad/TGFβ signaling, cell migration, invasion, and lung metastasis in MMTV/c-Neu mice and 4T1 orthotopic-grafted mice. EW-7197 also inhibited the epithelial-to-mesenchymal transition (EMT) in both TGFβ-treated breast cancer cells and 4T1 orthotopic-grafted mice. Furthermore, EW-7197 enhanced cytotoxic T lymphocyte activity in 4T1 orthotopic-grafted mice and increased the survival time of 4T1-Luc and 4T1 breast tumor-bearing mice. In summary, EW-7197 showed potent in vivo antimetastatic activity, indicating its potential for use as an anticancer therapy.
The CAR1 Gene Encoding a Cellular Receptor Specific for Subgroup B and D Avian Leukosis Viruses Maps to the Chicken <i>tvb</i> Locus (1998)

Host susceptibility to subgroup B, D, and E avian leukosis viruses (ALV) is determined by specific alleles of the chicken tvb locus. Recently, a chicken gene that encodes a cellular receptor, designated CAR1, specific for subgroups B and D ALV was cloned, and it was proposed that this gene was the s3 allele of tvb (J. Brojatsch, J. Naughton, M. M. Rolls, K. Zingler, and J. A. T. Young, Cell 87:845-855, 1996). We now report that in a backcross derived from an F1 (Jungle Fowl x White Leghorn [WL]) male mated with inbred WL females, the cloned ALV receptor gene cosegregated with two markers linked to tvb. The two markers used were a tvb(s1)-specific antigen recognized by the chicken R2 alloantiserum and restriction fragment length polymorphisms associated with the expressed sequence tag com152e. With all three markers, no crossovers were observed among 52 backcross progeny tested and LOD linkage scores of 15.7 were obtained. These data demonstrate that CAR1 is the subgroup B and D ALV susceptibility gene located at tvb(s3).