gebhart/patrepeval huggingface dataset:
Regulatory T Cells and the Development of Cancer Post Renal Transplantation (2012)

Aims: Kidney Transplant Recipients (KTR) have an increased risk of both cutaneous squamous cell cancer (SCC) and non-lymphoid cancer (NLC). High numbers of regulatory T cells (Tregs, ie. CD3+CD4+FOXP3+CD25highCD127low) and low numbers of Natural Killer (NK, ie. CD3-CD19-CD56+CD16+) cells have been shown to predict SCC development in KTR from the United Kingdom. These KTR were utilising predominantly calcineurin (CNI) and azathioprine (AZA) based immunosuppression regimens. This study investigated the Treg and NK cell immune phenotype in Australian KTR and the interaction with immunosuppressive regimen (CNI, AZA, mycophenolate (MMF) and mammalian target of rapamycin inhibitors (mTORi)) and cancer type (SCC and NLC). Methods: A cohort of 100 KTR were analyzed: 25 KTR with a history of cancer, 25 KTR with current cancer were matched by age, gender and duration of immunosuppression (±5 years) to 50 KTR without any history of cancer. Cancer types included: aggressive/high risk or metastatic SCC (n=32) and NLC (n=18). Twenty three KTR with cancer were prospectively followed to determine if cancer resection affected immune phenotype. The immune phenotype was assessed using multi-parameter flow cytometry with the operator blinded to the clinical status of the subjects. Results: The CD4+ lymphocyte count was significantly lower in KTR with history of cancer or current cancer when compared to KTR without cancer (p=0.013 and p< 0.001, respectively). The Treg proportions were higher in KTR with history of cancer or current cancer in comparison to KTR without cancer (p=0.003 and p< 0.001 respectively). Due to the relative CD4 lymphopenia, numbers of Treg were only higher in current cancer when compared to the KTR without cancer (p=0.006). When the KTR cohort was split into cancer type: SCC and NLC they were both significantly different to KTR without cancer (p=0.037 for both). NK cell numbers were not different between KTR with a history of cancer or current cancer in comparison to KTR without cancer. There were no differences in NK cell numbers across the cancer or immunosuppression groups. In general immunosuppressive regimen did not significantly affect Treg immune phenotype. However, CNI usage in KTR without cancer was associated with reduced Treg number. After cancer resection Treg numbers decreased significantly (p=0.014) but NK cell numbers were unchanged. There were no significant differences in immune phenotype in those KTR with current cancer who subsequently died of their malignancy. Conclusion: High numbers of Treg in KTR peripheral blood associates with not only high risk SCC but also NLC. Current cancer in KTR is associated with CD4 lymphopenia and increased Treg number, which decreased after cancer resection. This is the first report of decreased Treg numbers after cancer resection in KTR and suggests the tumor may affect immune phenotype. Studies are ongoing at our centre to determine the prognostic power of Treg monitoring in KTR on variable immunosuppressive regimens.
Effects of the protein corona on liposome–liposome and liposome–cell interactions (2016)

Claudia Corbo,1,2 Roberto Molinaro,1 Francesca Taraballi,1 Naama E Toledano Furman,1 Michael B Sherman,3 Alessandro Parodi,1 Francesco Salvatore,2,4 Ennio Tasciotti1,5 1Center for Biomimetic Medicine, Houston Methodist Research Institute, Houston, TX, USA; 2CEINGE-Biotecnologie Avanzate s.c.a r.l., Naples, Italy; 3Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA; 4Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy; 5Department of Orthopedics, Houston Methodist Hospital, Houston, TX, USA Abstract: A thorough understanding of interactions occurring at the interface between nanocarriers and biological systems is crucial to predict and interpret their biodistribution, targeting, and efficacy, and thus design more effective drug delivery systems. Upon intravenous injection, nanoparticles are coated by a protein corona (PC). This confers a new biological identity on the particles that largely determines their biological fate. Liposomes have great pharmaceutical versatility, so, as proof of concept, their PC has recently been implicated in the mechanism and efficiency of their internalization into the cell. In an attempt to better understand the interactions between nanocarriers and biological systems, we analyzed the plasma proteins adsorbed on the surface of multicomponent liposomes. Specifically, we analyzed the physical properties and ultrastructure of liposome/PC complexes and the aggregation process that occurs when liposomes are dispersed in plasma. The results of combined confocal microscopy and flow cytometry experiments demonstrated that the PC favors liposome internalization by both macrophages and tumor cells. This work provides insights into the effects of the PC on liposomes’ physical properties and, consequently, liposome–liposome and liposome–cell interactions. Keywords: liposomes, protein corona, macrophages, cancer cells
Intelligent Drug Delivery Systems (2009)

ADVERTISEMENT RETURN TO ISSUECommentNEXTIntelligent Drug Delivery SystemsYu-Kyoung Oh, Peter D. Senter, and Soo-Chang SongView Author Information School of Pharmacy, Seoul National University, Sinlim-dong, Kwanak-gu, Seoul 151-742, South Korea Seattle Genetics, 21823 30th Drive SE, Bothell, Washington 98021 Division of Life Science, Korea Institute of Science and Technology, Seoul 130-650, South Korea*[email protected]Cite this: Bioconjugate Chem. 2009, 20, 10, 1813–1815Publication Date (Web):September 3, 2009Publication History Received12 June 2009Revised28 July 2009Published online3 September 2009Published inissue 21 October 2009https://pubs.acs.org/doi/10.1021/bc900260xhttps://doi.org/10.1021/bc900260xarticle-commentaryACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views3726Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cancer therapy,Drug delivery,Drug release,Peptides and proteins,Pharmaceuticals Get e-Alerts
Resource management strategies for SDR clouds (2011)

This paper analyzes different resource management strategies for SDR base stations implemented as SDR clouds. SDR clouds describe distributed antennas that connect to a data center for digital signal processing. The data center employs cloud computing technology, providing a virtualized computing resource pool. The service area of a single SDR cloud may be a medium sized metropolitan area with a high user density. Hence, the data center will execute thousands of SDR applications—waveforms associated to different radio cells—in parallel. Whenever a user initiates or terminates a wireless communications session, computing resources need to be allocated or deallocated in real time. We therefore propose a hierarchical resource management approach and present simulation results that demonstrate its feasibility
Synthese von cytostatisch wirkenden Estern des 1‐Äthylenimino‐2‐hydroxy‐butens‐(3) (1962)

Abstract Cytostatisch wirkende Carbonsäure‐ und Carbamidsäure‐ester von 1‐Äthylenimino‐2‐hydroxy‐buten‐(3) („Tetramin”︁) wurden nach der Imidazolidmethode synthetisiert.
Accuracy improvement and cost reduction of 3-step search block matching algorithm for video coding (1994)

Proposes three modifications on the 3-step hierarchical search for video coding: the multiple-candidate search that improves the estimation accuracy, a method of subsampling that reduces computation and input data amount, and an overlapping strategy to improve the accuracy of a large-area search. Experimental results show that combining these techniques provides high-speed and high-precision motion estimators with reduced on-chip buffers and lower input bandwidth requirements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Organised Crime and Common Transit Networks (2002)

The Australian Institute of Criminology has produced a diverse range of studies on illicit markets, including those in drugs, diamonds, stolen vehicle parts, abalone, plastic payment cards and antiquities. This paper draws together information on one aspect that these markets have in common— networks of transportation. In view of the common structure of these networks for transporting and distributing illicit goods, and the common nature of the skills required to successfully operate underground trading links, this paper questions whether the same personnel are involved in the movement of all or some of these goods and, if so, what implications this might have for crime prevention and detection initiatives.
A Cell System with Targeted Disruption of the SMNGene (2001)

The motor neuron degenerative disease spinal muscular atrophy is caused by reduced expression of the survival motor neuron (SMN) protein. Here we report a genetic system developed in the chicken pre-B cell line DT40, in which the endogenous SMN gene is disrupted by homologous recombination, and SMN protein is expressed from a chicken SMN cDNA under control of a tetracycline (tet)-repressible promoter. Addition of tet results in depletion of SMN protein and consequent cell death, which directly demonstrates that SMN is required for cell viability. The tet-induced lethality can be rescued by expression of human SMN, indicating that the function of SMN is highly conserved between the two species. Cells expressing low levels of SMN display slow growth proportional to the amount of SMN they contain. Interestingly, the level of the SMN-interacting protein Gemin2 decreases significantly following depletion of SMN, supporting the conclusion that SMN and Gemin2 form a stable complex in vivo. This system provides a powerful setting for studying the function of SMN in vivo and for screening for potential therapeutics for spinal muscular atrophy.
Characteristic spin fluctuations in Y(Mn<sub>1-x</sub>Al<sub>x</sub>)<sub>2</sub> (1987)

The thermal expansion and magnetic susceptibility have been measured for Y(Mn1-xAlx)2 pseudobinary Laves phase intermetallic compounds. A large volume change at TN and a remarkable enhancement of the thermal expansion coefficient above TN were observed in YMn2. The substitution of Al for Mn makes these anomalies less clear. The temperature dependence of the susceptibility, being almost temperature independent for YMn2, becomes of the Curie-Weiss type as the Al content increases. Such behaviour is explained as the characteristic features of spin fluctuations. The amplitude of local spin fluctuations at the Mn site has been estimated on the basis of the phenomenological theory of magnetovolume effects. It has been revealed that the magnetic ground state of Al-substituted compounds is a spin glass.
Descriptions of new species of turtles of the genus Testudo, collected from the Miocene by the Carnegie Museum; together with a description of the skull of Stylemys nebrascensis (1906)

This species has as its type No.
Combined Process of CO<sub>2</sub> Capture by Potassium Carbonate and Production of Basic Zinc(II) Carbonates: CO<sub>2</sub> Release from Bicarbonate Solutions at Room Temperature and Pressure (2008)

The absorption of CO2 in aqueous solutions of K2CO3 has been investigated at six different temperatures in the range 10–60 °C and at atmospheric pressure. The CO2 absorption is fast and occurs with high efficiency without any added catalytic activator. The CO2 capture ranges between 83 and 99% expressed as the percentage of absorbed CO2 with respect to the neat CO2 flowing through the absorbent solution. The efficiency of CO2 removal increases with the temperature, which contrasts with the exoenthalpic nature of the reaction between CO2 and CO32− and the diminished solubility of CO2 at high temperature. Our finding indicates that the increase of the CO2/CO32− reaction rate with the temperature prevails over the opposite effect on the equilibrium due to the temperature increase. The stripping of pure CO2 from the HCO3− solutions has been achieved by adding a zinc(II) salt to the absorbed solutions which releases the captured CO2 rapidly and completely at room temperature and pressure with the simultaneous separation of solid compounds identified as mixtures of commercially valuable basic zinc carbonates. Although the exact evaluation of the overall merits of the proposed CO2 capturing technology would require a complete analysis of the energy profile of the process, it is obvious that any improvement of the CO2 capture process resulting in the associated synthesis of a valuable product without additional energy burdening reduces the cost of CO2 capture and maximizes the neat balance CO2(captured) − CO2(emitted) where CO2(emitted) represents the total energy bill (electrical, thermal, mechanical) required to sustain the entire cycle of CO2 abatement.
Concentration effect of sodium carbonate and sodium aluminate as accelerator and H2O mixing against physical properties: Flow ability, setting time, and strength in low cement castable refractory product (Case study: PT. Indoporlen) (2017)

The research was intended to analyze effect of comparison concentration between accelerator and H2O mixing against characterization of flow ability, setting time and strength at low cement castable refractory product (case study at PT. Indoporlen Refractory), Shown the kinds of accelerator sodium aluminate and sodium carbonate have good characterization result against flow ability and setting time while additional H2O mixing conclude to good strength with different kinds of temperature at 110 °C, 900 °C and 1450 °C which revealed the measurement are above to allowed specification and as well the strength test coming from accelerator of sodium aluminate and sodium carbonate in various concentration 0.01% until 0.04% and with various of H2O mixing 5.0 until 6.5% achieves the strength above in allowed specification of PT. Indoporlen.
Speed and power factor controller for AC adjustable speed drives (1991)

The speed and power factor of an adjustable speed slip power recovery drive are controlled in order to optimize the operation. This is accomplished by means of a variable-voltage-variable-frequencies power converter. The function of the digital controller of the power converter is to provide the online speed and power factor regulation. The hardware and software are described. This scheme has an accurate voltage output with very low harmonic content, a good resolution for the phase angle regulation and the frequency control with the possibility of range extension.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
44.2: Mass Manufacturing of Full Color Passive‐Matrix and Active‐Matrix PLED Displays (2004)

Abstract Philips is preparing the mass production of passive‐ and active‐matrix full‐color polymer OLED displays with ink jet printing. Several major technical challenges had to be solved en route to mass production: First, a reliable and fast full‐color inkjet printing process had to be developed for high‐resolution displays. Second, material lifetimes had to be brought to sufficient levels under real application conditions using inkjet printing. Finally, the necessary mass production equipment had to made available including the accurate stage, the plate handling, and the print heads.
Trabecular Carcinoma of the Skin (1972)

Five patients had trabecular carcinomas of the skin. The growths originate within the dermis or in the immediate subcutis, and display a uniform morphology. They are composed of solid trabeculae that lack definite acini. A derivation from cells that are capable of reproducing primitive sudoriferous structures is postulated. The lesions have been encountered in elderly patients of both sexes, and the larger tumors have disseminated actively by lymphatic pathways. Trabecular carcinomas may occasion diagnostic difficulty, for they may be misinterpreted as cutaneous metastases from visceral cancers. The histological features of these tumors are not sufficiently distinctive to permit differentiation from anaplastic metastatic carcinomas. Confirmation of their primary dermal origin is dependent upon the clinical outcome. Familiarity with their existence is, however, of importance in the evaluation of cutaneous malignancy.
High tibial osteotomy with fixation by a blade plate for medial compartment osteoarthritis of the knee. (1989)

Surgical techniques were described on tibial osteotomy above the tuberosity, the fragments of which were fixed with a Koshino blade plate. Postoperative clinical results on 176 knees with medial compartment osteoarthritis of 138 patients with an average age of 62.1 years were excellent in 110 and good in 55 knees with an average of 5.5 years' follow-up. The best knee score was obtained in the knee with postoperative limb alignment of 6 to 15 degree valgus angulation (standing). The results were satisfactory, especially in postoperative management, which was much easier with the Koshino blade plate fixation than with other methods. The sinking of the osteotomy site was checked through observation of screw movement in the slot of the plate during postoperative management in 53 selected knees, and the averaged distance of sinking was 3.9 +/- 2.5 mm. The time of mechanical bone union judged by cessation of sinking averaged 12.9 +/- 6.2 weeks after osteotomy.
Design of wide energy range coded aperture mask of an environment radiation monitoring system (2007)

It is of significant importance to develop an environment radiation monitoring system since the tracking and management of radiation sources are becoming more and more important in many sectors such as nuclear power plants, hospitals, isotope production facilities, research laboratories and so on. In this paper, we designed a coded aperture mask used in an environment radiation monitoring system, which is able to locate gamma-ray sources in the environment as well as to do the spectrum analysis of them. We determine the parameters of the coded aperture system through existed coded aperture theories and Monte-Carlo simulation to achieve high sensitivity, large field of view (FOV), best image quality in a wide energy range, and also acceptable spatial resolution. We defined a new figure of merit (FoM) which is different from the conventional FoM to evaluate the quality of the reconstructed images of the Monte-Carlo simulation. Using the anti-symmetric mask pattern (i.e. the mask exchange the blocked and hole pixels in the mask upon a 90 degree rotation, except the pixel in the center), the system is able to overcome the unavoidable detector deficiency and also has the potential to be used in a near-field situation with little near-field artifact. According to preliminary simulations, the mask design could enable Cs-137 and Co-57 imaging at an excellent image quality.
Rotavirus Vaccines: an Overview (2008)

Rotavirus infection is the most common cause of severe diarrhea disease in infants and young children worldwide and continues to have a major global impact on childhood morbidity and mortality. Vaccination is the only control measure likely to have a significant impact on the incidence of severe dehydrating rotavirus disease. In 1999, a highly efficacious rotavirus vaccine licensed in the United States, RotaShield, was withdrawn from the market after 14 months because of its association with intussusception. Two new live, oral, attenuated rotavirus vaccines were licensed in 2006: the pentavalent bovine-human reassortant vaccine (RotaTeq) and the monovalent human rotavirus vaccine (Rotarix). Both vaccines have demonstrated very good safety and efficacy profiles in large clinical trials in western industrialized countries and in Latin America. Careful surveillance has not revealed any increased risk of intussusception in the vaccinated groups with either vaccine. The new rotavirus vaccines are now introduced for routine use in a number of industrialized and developing countries. These new safe and effective rotavirus vaccines offer the best hope of reducing the toll of acute rotavirus gastroenteritis in both developed and developing countries.
Synthesis and structure of thermotropic main-chain polyethers based on bis(4-hydroxyphenoxy)-p-xylene (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structure of thermotropic main-chain polyethers based on bis(4-hydroxyphenoxy)-p-xyleneHaakan Jonsson, Per Erik Werner, Ulf W. Gedde, and Anders HultCite this: Macromolecules 1989, 22, 4, 1683–1689Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/ma00194a031https://doi.org/10.1021/ma00194a031research-articleACS PublicationsRequest reuse permissionsArticle Views152Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts