gebhart/patrepeval huggingface dataset:
Global Transcriptional Analysis of<i>clpP</i>Mutations of Type 2<i>Streptococcus pneumoniae</i>and Their Effects on Physiology and Virulence (2002)

Streptococcus pneumoniae is an important human pathogen that contains single copies of genes encoding the ClpP and FtsH ATP-dependent proteases but lacks the Lon and HslV proteases. We constructed and characterized the phenotypes of clpP, clpC, and clpX deletion replacement mutants, which lack the ClpP protease subunit or the putative ClpC or ClpX ATPase specificity factor. A DeltaclpP mutant, but not a DeltaclpC or DeltaclpX mutant, of the virulent D39 type 2 strain of S. pneumoniae grew poorly at 30 degrees C and failed to grow at 40 degrees C. Despite this temperature sensitivity, transcription of the heat shock regulon determined by microarray analysis was induced in a DeltaclpP mutant, which was also more sensitive to oxidative stress by H2O2 and to puromycin than its clpP+ parent strain. A DeltaclpP mutant, but not a DeltaclpC mutant, was strongly attenuated for virulence in the murine lung and sepsis infection models. All of these phenotypes were complemented in a DeltaclpP/clpP+ merodiploid strain. Consistent with these complementation patterns, clpP was found to be in a monocistronic operon, whose transcription was induced about fivefold by heat shock in S. pneumoniae as determined by Northern and real-time reverse transcription-PCR analyses. Besides clpP, transcription of clpC, clpE, and clpL, but not clpX or ftsH, was induced by heat shock or entry into late exponential growth phase. Microarray analysis of DeltaclpP mutants showed a limited change in transcription pattern (approximately 80 genes) consistent with these phenotypes, including repression of genes involved in oxidative stress, metal ion transport, and virulence. In addition, transcription of the early and late competence regulon was induced in the DeltaclpP mutant, and competence gene expression and DNA uptake seemed to be constitutively induced throughout growth. Together, these results indicate that ClpP-mediated proteolysis plays a complex and central role in numerous pneumococcal stress responses, development of competence, and virulence.
Photochemistry of “End-Only” Oligo-<i>p</i>-phenylene Ethynylenes: Complexation with Sodium Dodecyl Sulfate Reduces Solvent Accessibility (2013)

Cationic oligo-p-phenylene ethynylenes are very effective light-activated biocides and biosensors but degrade upon exposure to light. In this study, we explore the photochemistry of a class of "end-only" compounds from this series, which have cationic moieties on the ends of the backbone. Product characterization by mass spectrometry reveals that the photoreactivity of these molecules is higher than that of a previously studied oligomer and that the primary products of photolysis result from the addition of water or oxygen across the triple bond. In addition, a product suggesting the addition of peroxide or other reactive oxygen species across the triple bond was observed. To explore avenues by which the photodegradation of these compounds can be mitigated, the effects of complexation with sodium dodecyl sulfate micelles on their photochemistry was explored. Classical molecular dynamics simulations revealed that compounds that were protected from photolysis by SDS buried their phenylene ethynylene backbones into the interior of the micelle, protecting it from contact with water. This work has revealed a molecular basis for the protection of a novel class of light-activated biocides from irradiation that is consistent with the proposed photochemistry of these compounds. This information can be useful for developing photodegradation-resistant biocidal materials and applications for current compounds and leads to new molecular design.
β2-Microglobulin Adsorption Column Reduces Digoxin Trough Level During Hemodialysis (2004)

We have previously reported that a beta2-microglobulin adsorption column for the treatment of dialysis-related amyloidosis decreased serum digoxin concentration in renal failure patients. Because the distribution volume of digoxin is high, it is uncertain whether the repetitive use of this column influences the pharmacokinetics of digoxin in renal failure patients. We have observed 3 renal failure patients whose trough serum digoxin concentrations were significantly reduced by the repetitive use of tandem beta2-microglobulin adsorption columns for treatment of dialysis-related amyloidosis. These patients experienced symptomatic elevation of their heart rates in parallel with a significant reduction in serum digoxin concentrations. Termination of the use of the adsorption column improved the symptoms in 1 patient; however, severe arthritic pain caused by amyloidosis relapsed. Dosage of digoxin was increased in 2 other patients with continuous treatment by the column. Their digoxin concentrations increased, and their heart rates decreased without any deterioration of joint pain. We have demonstrated that the repetitive use of the beta2-microglobulin adsorption column in tandem with standard hemodialysis actually decreases trough digoxin concentration in renal failure patients. Careful monitoring and alteration of digoxin dosage regimens are needed under these circumstances.
The occurrence of postreperfusion syndrome in orthotopic liver transplantation and its significance in terms of complications and short-term survival (2011)

PRS occurrence seems to be associated with higher mortality rate and worse patient outcome. The study revealed a few risk factors that could be relevant in the prevention of PRS.
Binding of pertussis toxin to lipid vesicles containing glycolipids (1993)

The binding of pertussis toxin and its B oligomer to lipid vesicles containing glycosphingolipids was studied. Both pertussis toxin and the B oligomer bound to lipid vesicles containing ganglioside GD1a. Binding of pertussis toxin to these vesicles decreased upon treatment of the vesicles with neuraminidase, suggesting that sialic acid residues are important for efficient binding of the toxin to GD1a.
Inhibition of HBV Infection in Mouse Model by Dual Small Interfering RNA Treatment (2009)

Objective To explore the therapeutic potential of RNAi on mutation in HBV genome resulting in resistance when small interfering RNA (siRNA) is futher developed as an anti-viral drug, we express simultaneously two different 21-bp hairpin siRNA duplexes that specifically attack the HBs and HBx genes of HBV, respectively, in vivo. Methods We copied the acute HBV mice model in the study, using hydrodynamics with the mouse tail. The same technique was used to treat with interfering RNA in vivo. The antigens and DNA of HBV were determined with ELISA, Immunohistochemical staining and real-time RT-PCR. Results Dual siRNA could inhibit simultaneously the level of viral DNA and viral antigens detected in the livers and sera of the treated mice relative to control animals. Conclusion This dual siRNA system provides a more powerful tool to inhibit HBV replication in vivo.
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) (2017)

Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology. We recently disclosed in vivo chemical tool 1 (GNE-272) for the bromodomain of CBP that was moderately potent and selective over BRD4(1). In pursuit of a more potent and selective CBP inhibitor, we used structure-based design. Constraining the aniline of 1 into a tetrahydroquinoline motif maintained potency and increased selectivity 2-fold. Structure-activity relationship studies coupled with further structure-based design targeting the LPF shelf, BC loop, and KAc regions allowed us to significantly increase potency and selectivity, resulting in the identification of non-CNS penetrant 19 (GNE-781, TR-FRET IC<sub>50</sub> = 0.94 nM, BRET IC<sub>50</sub> = 6.2 nM; BRD4(1) IC<sub>50</sub> = 5100 nΜ) that maintained good in vivo PK properties in multiple species. Compound 19 displays antitumor activity in an AML tumor model and was also shown to decrease Foxp3 transcript levels in a dose dependent manner.
BROKEN SLEEP (1986)

Terri E. Weaver, RN, MSN, CS, is a pulmonary clinical nurse specialist and a doctoral student and teaching assistant at the University of Pennsylvania School of Nursing, Philadelphia. Richard P. Millman, MD, is director, pulmonary function and sleep apnea laboratories, Rhode Island Hospital, Providence.
Characterization of packetized voice traffic in ATM networks using neural networks (2002)

Asynchronous transfer mode (ATM) broadband networks support a wide range of multimedia traffic (e.g. voice, video, image and data). Accurate characterization of the multimedia traffic is essential in ATM networks, in order to develop a robust set of traffic descriptors. Such a set is required by the ATM networks for the important functions of traffic enforcement (policing) and bandwidth allocation utilizing the statistical multiplexing gain. In this paper, we present a novel approach to characterize and model the multimedia traffic using neural networks (NNs). A backpropagation NN is used to characterize the statistical variations of the packet arrival process resulting from the superposition of a number of packetized voice sources. The NN is trained to characterize the arrival process over a fixed measurement period of time, based upon sampled values taken from the previous measurement period. The accuracy of the results were verified by matching the index of dispersion for counts and the variance of the arrival process to those of the NN output. The results reported show that the NNs can be successfully utilized to characterize the complex non-renewal process resulting from the aggregate voice-packet arrival process with extreme accuracy. Hence, NNs have excellent potential as traffic descriptors for the usage parameter control algorithm used in admission control and traffic enforcement in ATM networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The optical design of the X-shooter for the VLT (2006)

The overall optical design of X-Shooter, the second generation, wide band, intermediate resolution, high efficiency, three-arms spectrograph for the VLT, is presented. We focus on the optical design of the three optimized arms, covering UVB (300-550 nm), VIS (550-1000 nm), and NIR (1000-2300 nm) wavelength ranges, including spectrographs and pre-slit optics. All spectrographs share the same original "4C" concept (Collimator Correction of Camera Chromatism). We describe also the auxiliary optics, such as dichroics, acquisition and guiding unit. Performances analysis are summarized.
The pyrethrins and related compounds: X.—The methylbenzyl chrysanthemates (1970)

Abstract New or improved routes are used to prepare all the nineteen methylbenzyl chrysanthemates, including 2,4,6‐trimethylbenzyl (+) and (−)‐ trans ‐chrysanthemates, 2,3,4,6‐tetramethyl‐and 2,3,4,5,6‐pentamethyl‐benzyl chrysanthemates, and the chrysanthemates of the new alcohols, 2,3,5‐and 3,4,5‐trimethylbenzyl alcohols.
Bipyridine Complexes (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBipyridine ComplexesG. Atkinson and J. BaumanCite this: Inorg. Chem. 1963, 2, 5, 1082Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ic50009a059https://doi.org/10.1021/ic50009a059research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Comparison of the Events and Relations Across ACE, ERE, TAC-KBP, and FrameNet Annotation Standards (2014)

Jacqueline Aguilar, Charley Beller, Paul McNamee, Benjamin Van Durme, Stephanie Strassel, Zhiyi Song, Joe Ellis. Proceedings of the Second Workshop on EVENTS: Definition, Detection, Coreference, and Representation. 2014.
가오싱지안(高行健) 영화론 - 와 를 중심으로- (2012)

This work has tried to review Gao Xing-jian`s films. Gao is Chinese French who has exiled because of political oppression on his works of art. He has directed two films: one is La Silhouette sinon l`ombre(2006), another is APRES LE DELUGE(2008). There is an objection that was already raised by myself to producing knowledge and building up discourse on Gao in Korea. For this reason I have argued intertextuality his own works, and considered the ways how the signification of the inner-texts meets some contexts in outer-texts as an advocate for contextuality and articulation for overcoming some gaps and splits between object and subject of study. Firstly it has argued the relationship of La Silhouette sinon l`ombre and APRES LE DELUGE. Despite of some differences like running time or the method of using and arranging images, APRES LE DELUGE has succeed La Silhouette sinon l`ombre from various angles something like atmosphere, style, shots, hybridity of identity. Secondly, it has also argued the signification of his films is very similar to poetic signs: they have excluded narrative and arranged images with non-lineal method. It could borrowed the argument of poetic cinema by Pier Paolo Pasolini. Especially his concept, free indirect point of view shot, a requisite of poetic cinema is discovered repeatedly in his films. However, in conclusion, it has presented those requisites of form or style could not explain some in-depth signification of his films, it would be secured from understanding context as the conditions that could created those form and styles. Gao has problematized hybridity of self identity articulating his own life history with arranging ambiguous images. And it is connected to some post-colonial interpretations.
The architecture and system method of DDM1 (1978)

An architecture for a highly modular, recursively structured class of machines is presented. DDM1 is an instance of such a machine structure, and is capable of executing machine language programs which are data driven nets. These nets may represent arbitrary amounts of concurrency as well as arbitrary amounts of pipelining. DDM1 is a fully distributed multiprocessing system composed of completely asynchronous modules. The architecture allows for limitless physical extensibility without necessitating special programming or special hardware to support individual machines of widely varying sizes. DDM1 is capable of automatically and dynamically allocating concurrent tasks to the available physical resources. The essential characteristics of the highly parallel, pipelined machine language are also described along with its method for execution on DDM1.
Fogbed: A Rapid-Prototyping Emulation Environment for Fog Computing (2018)

The fog computing paradigm extends cloud resources near data sources to overcome limitations of cloud-based IoT centralized architectures. Its involve the running of services and applications on the nodes between the IoT devices and the cloud. The prototyping and testing of these distributed software is challenging due to the fact that not only the fog service has to be tested but also its integration with management systems. Despite recent advances in fog platforms, there exists no readily available testbed which can help researchers to design and test real world fog applications. To this purpose, network simulators and cloud middleware are adapted to enable the investigation of fog solutions. This paper presents Fogbed, a framework and toolset integration for rapid prototyping of fog components in virtualized environments. Using a desktop approach, Fogbed enables the deployment of fog nodes as software containers under different network configurations. Its design meets the requirements of low cost, flexible setup and compatibility with real world technologies. Unlike current approaches, the proposed framework allows for the testing of fog components with third-party systems through standard interfaces. A scheme to observe the behavior of the environment is provided. A case study is presented to demonstrate a fog service analysis. In addition, future developments and research directions are discussed.
Electrical safety for an electrical impedance tomograph (2003)

The electrical safety requirements for patient lead currents in medical electrical equipment are reviewed. The standards set by four organizations are compared. These are the National Fire Protection Association (NFPA), the Association for the Advancement of Medical Instrumentation (AAMI), Underwriters Laboratories (UL), and the International Electrotechnical Commission (IEC). Patient lead current classification, lead-to-ground leakage and risk currents, and leakage between patient leads are discussed. Isolation transformers and optoisolators are proposed for use in an electrical impedance tomograph to meet these requirements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Measurment of astigmatism in microlithography lenses (1998)

The direction, (phi) , and magnitude, A<SUB>1</SUB>, of residual astigmatism in microlithography lenses used for semiconductor circuit fabrication is determined by measuring the focal position, F, of lines orientated at four values of (Theta) equals 0 degrees, 45 degrees, 90 degrees, 135 degrees. These parameters are related by F equals A<SUB>0</SUB> plus A<SUB>1</SUB> cos2((Theta) + (phi) ) which is solved for the four measured values of F. If the lens is axially symmetric the angle (phi) will be that of the field diameter, but real lenses have fabrication errors that may introduce non-classical astigmatism, so (phi) may have values 0 less than or equal to (phi) less than or equal to (pi) at any point in the field. It is for this reason that conventional resolution reticles with perpendicular resolution targets are inadequate to accurately measure residual astigmatism. Using such a reticle will result in under estimation of the actual astigmatism. Wafers are exposed through focus using a reticle having an array of resolution targets, each having the four orientations. Measuring the focal position of each of the four orientations by examination of their photoresist images with a dark field optical microscope enables determination of astigmatism with a standard deviation 7 nm. Application of this procedure used to evaluate the residual astigmatism in high quality lithography lens is reported.
Metabolism of polycyclic compounds. 5. Formation of 1:2-dihydroxy-1:2-dihydronaphthalenes (1949)

Research Article| January 01 1949 Metabolism of polycyclic compounds. 5. Formation of 1:2-dihydroxy-1:2-dihydronaphthalenes Joan Booth; Joan Booth 1The Chester Beatty Research Institute, Royal Cancer Hospital, London, S.W. 3 Search for other works by this author on: This Site PubMed Google Scholar E. Boyland E. Boyland 1The Chester Beatty Research Institute, Royal Cancer Hospital, London, S.W. 3 Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1949) 44 (3): 361–365. https://doi.org/10.1042/bj0440361 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation Joan Booth, E. Boyland; Metabolism of polycyclic compounds. 5. Formation of 1:2-dihydroxy-1:2-dihydronaphthalenes. Biochem J 1 January 1949; 44 (3): 361–365. doi: https://doi.org/10.1042/bj0440361 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1949 CAMBRIDGE UNIVERSITY PRESS1949 Article PDF first page preview Close Modal You do not currently have access to this content.
THERMALNET: A DEEP CONVOLUTIONAL NETWORK FOR SYNTHETIC THERMAL IMAGE GENERATION (2017)

Abstract. Deep convolutional neural networks have dramatically changed the landscape of the modern computer vision. Nowadays methods based on deep neural networks show the best performance among image recognition and object detection algorithms. While polishing of network architectures received a lot of scholar attention, from the practical point of view the preparation of a large image dataset for a successful training of a neural network became one of major challenges. This challenge is particularly profound for image recognition in wavelengths lying outside the visible spectrum. For example no infrared or radar image datasets large enough for successful training of a deep neural network are available to date in public domain. Recent advances of deep neural networks prove that they are also capable to do arbitrary image transformations such as super-resolution image generation, grayscale image colorisation and imitation of style of a given artist. Thus a natural question arise: how could be deep neural networks used for augmentation of existing large image datasets? This paper is focused on the development of the Thermalnet deep convolutional neural network for augmentation of existing large visible image datasets with synthetic thermal images. The Thermalnet network architecture is inspired by colorisation deep neural networks.