gebhart/patrepeval huggingface dataset:
Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo (2016)

New therapies for glioblastoma (GBM) are needed, as five-year survival is <10%. The proteasome inhibitor marizomib (MRZ) has inhibitory and death-inducing properties unique from previous inhibitors such as bortezomib (BTZ), and has not been well examined in GBM. We evaluated the mechanism of death and in vivo properties of MRZ in GBM. The activation kinetics of initiator caspases 2, 8, and 9 were assessed using chemical and knockdown strategies to determine their contribution to cell death. Blood brain barrier permeance and proteasome inhibition by MRZ and BTZ were examined in an orthotopic GBM model. Blockade of caspase 9, relative to other caspases, was most protective against both MRZ and BTZ. Only MRZ increased the proteasome substrate p27 in orthotopic brain tumors after a single injection, while both MRZ and BTZ increased p21 levels after multiple treatments. Cleavage of caspase substrate lamin A was increased in orthotopic brain tumors from mice treated with MRZ or BTZ and the histone deacetylase inhibitor vorinostat. Our data indicate that MRZ induces caspase 9-dependent death in GBM, suggesting drug efficacy biomarkers and possible resistance mechanisms. MRZ reaches orthotopic brain tumors where it inhibits proteasome function and increases death in combination with vorinostat.
A structured fixed-rate vector quantizer derived from a variable-length scalar quantizer. I. Memoryless sources (1993)

A low-complexity, fixed-rate structured vector quantizer for memoryless sources is described. This quantizer is referred to as the scalar-vector quantizer (SVQ), and the structure of its codebook is derived from a variable-length scalar quantizer. Design and implementation algorithms for this quantizer are developed and bounds on its performance are provided. Simulation results show that performance close to that of the optimal entropy-constrained scalar quantizer is possible with the fixed-rate quantizer. The SVQ is also robust against channel errors and outperforms both Lloyd-Max and entropy-constrained scalar quantizers for a wide range of channel error probabilities.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Electrochemical Sodium Insertion into the 3D-framework of Na_3M_2(PO_4)_3 (M=Fe, V) (2002)

Insertion of sodium into phosphates Na_3M_2 (PO_4)_3 (M=Fe, V) were investigated electrochemically to determine the usefulness as the possible cathodes for sodium batteries. The discharge curves show that sodium ion can be accommodated into these hosts. Specific charges of up to 45mAhg^<-1> and 140mAhg^<-1> were obtained for Na/Na_3Fe_2 (PO_4)_3 and Na/Na_3V_2(PO_4)_3 cells with liquid organic electrolytes at room temperature, respectively. Intercalation processes under constant current densities of 0.1mAcm^<-2> were reversible within the range of composition 3.0<x<3.4 for Na_xFe_2 (PO_4)_3 and 1.2<x<3.8 for Na_xV_2 (PO_4)_3.
Streptococcus pneumoniae Serotype-2 Childhood Meningitis in Bangladesh: A Newly Recognized Pneumococcal Infection Threat (2012)

S. pneumoniae serotype-2 was found to possess an unusually high potential for causing meningitis and was the leading serotype-specific cause of childhood meningitis in Bangladesh over the past decade. Persisting disease occurrence or progressive spread would represent a major potential infection threat since serotype-2 is not included in PCVs currently licensed or under development.
Isoprenylation/Methylation of Proteins Enhances Membrane Association by a Hydrophobic Mechanism (1996)

ADVERTISEMENT RETURN TO ISSUENew Concepts in Bioc...New Concepts in BiochemistryNEXTIsoprenylation/Methylation of Proteins Enhances Membrane Association by a Hydrophobic Mechanism†Craig A. Parish and Robert R. RandoView Author Information Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts 02115 Cite this: Biochemistry 1996, 35, 26, 8473–8477Publication Date (Web):July 2, 1996Publication History Received11 March 1996Revised1 May 1996Published online2 July 1996Published inissue 1 January 1996https://doi.org/10.1021/bi960603gCopyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views218Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (255 KB) Get e-AlertsSUBJECTS:Membranes,Modification Get e-Alerts
Simple and low-cost silicon Fabry-Perot filter for WDM channel monitoring (2002)

We propose a simple and low-cost solution for tracking the frequency of WDM channels, based on the thermo-optic tuning of Fabry-Perot silicon optical filters. The fabricated structures exhibit, due to a suitable coating stack on both cavity sides, high finesse and narrow bandwidth. Moreover, the free spectral range is large compared to the channel spacing, allowing the monitoring of one carrier frequency at a time. By means of a heater we change the cavity refractive index and move the transmission peaks, thus scanning the WDM frequency set. In particular, in a preliminary prototype realized by using a 100-/spl mu/m-long silicon cavity we demonstrate the possibility to resolve up to seven 50-GHz-spaced channels, with a crosstalk of -10 dB, at wavelengths around 1550 nm. More channels are easily resolvable by using shorter cavities.
THE MALE CLIMACTERIC (1939)

It seems reasonable to believe that many if not all men pass through a climacteric period somewhat similar to that of women, usually in a less severe but perhaps more prolonged form. The cessation of menstruation in the female at the so-called change of life has been tangible evidence for ages that the woman is having a decline in her sex function and is approaching the end of her child-bearing period. This cessation of menstruation in the female, usually called the menopause, is not the climacteric but represents only visible evidence that the woman is having endocrine imbalance. The endocrine dysfunction, plus the imbalance of equilibrium between the two divisions of the autonomic nervous system, with evidence at times of disturbance in the psychic centers, is the climacteric. The true climacteric is due primarily to decline of function of the sex glands. Decline of sex function is not limited to
Subtractive Cloning and Characterization of DRAL, a Novel LIM-Domain Protein Down-Regulated in Rhabdomyosarcoma (1997)

A subtractive cloning procedure was used to characterize the molecular changes involved in transformation of normal myoblasts to rhabdomyosarcoma (RMS) cells. Here we describe the cloning of DRAL, a novel LIM-domain protein expressed in primary myoblasts but down-regulated in the RMS cell line RD. DRAL is a LIM-only protein with five LIM domains whereby one LIM domain consists only of the second half of the consensus motif. Interestingly, down-regulation of DRAL was not confined to the RD RMS cells, but was a phenomenon extended to other RMS cell lines of both embryonal and alveolar subtype, and to some breast cancer cell lines. Analysis of the expression pattern in normal human tissues revealed that DRAL is expressed at high levels in the heart, suggesting an important function in the specification of the terminally differentiated phenotype of heart muscle cells. Immunofluorescence studies using an antibody directed against recombinant DRAL localized the protein predominantly in the nucleus of cultured cells. On the basis of these results, we conclude that down-regulation of DRAL correlates with the tumor phenotype of RMS cells.
Predicting five-year outcome for patients with cutaneous melanoma in a population-based study (1996)

In this population-based study of 548 patients in Connecticut, tumor thickness was the most significant prognostic factor for survival of patients with localized cutaneous melanoma. Other prognostic factors studied to date have not been conclusively verified as providing any additional information beyond that of tumor thickness.
The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. (1995)

The Silent Information Regulatory proteins, Sir3 and Sir4, and the telomeric repeat-binding protein RAP1 are required for the chromatin-mediated gene repression observed at yeast telomeric regions. All three proteins are localized by immunofluorescence staining to foci near the nuclear periphery suggesting a relationship between subnuclear localization and silencing. We present several lines of immunological and biochemical evidence that Sir3, Sir4, and RAP1 interact in intact yeast cells. First, immunolocalization of Sir3 to foci at the yeast nuclear periphery is lost in rap1 mutants carrying deletions for either the terminal 28 or 165 amino acids of RAP1. Second, the perinuclear localization of both Sir3 and RAP1 is disrupted by overproduction of the COOH terminus of Sir4. Third, overproduction of the Sir4 COOH terminus alters the solubility properties of both Sir3 and full-length Sir4. Finally, we demonstrate that RAP1 and Sir4 coprecipitate in immune complexes using either anti-RAP1 or anti-Sir4 antibodies. We propose that the integrity of a tertiary complex between Sir4, Sir3, and RAP1 is involved in both the maintenance of telomeric repression and the clustering of telomeres in foci near the nuclear periphery.
Eutectic Molten Salt Thermal Storage System (1969)

Abstract : An analysis of various thermal storage materials indicated that a eutectic mixture of lithium hydroxide and lithium fluoride would provide relatively high heat capacity for a closed-cycle thermal propulsion system for deep-running underwater vehicles. In contrast with other high-heat-capacity lithium compounds, this eutectic mixture undergoes practically no expansion during fusion. It has a low melting point of 800F. It does not react chemically with water, but does absorb small amounts of water if directly exposed to steam at high pressure. LiF-LiOH corrosion tests on samples of various metals, including 304 stainless steel and Inconel 600, indicated that corrosion may occur at random at temperatures above 900F. From 900F to 1200F, Inconel 600 indicated the least corrosion of any high-strength material tested.
Characterization & analysis of a server consolidation benchmark (2008)

Virtualization is already becoming ubiquitous in data centers for the consolidation of multiple workloads on a single platform. However, there are very few performance studies of server consolidation workloads in the literature. In this paper, our goal is to analyze the performance characteristics of a representative server consolidation workload. To address this goal, we have carried out extensive measurement and profiling experiments of a newly proposed consolidation workload (vConsolidate). vConsolidate consists of a compute intensive workload, a web server, a mail server and a database application running simultaneously on a single platform. We start by studying the performance slowdown of each workload due to consolidation on a contemporary multi-core dual-processor Intel platform. We then look at architectural characteristics such as CPI (cycles per instruction) and L2 MP (L2 misses per instruction) I, and analyze the benefits of larger caches for such a consolidated workload. We estimate the virtualization overheads for events such as context switches, interrupts and page faults and show how these impact the performance of the workload in consolidation. Finally, we also present the execution profile of the server consolidation workload and illustrate the life of each VM in the consolidated environment. We conclude by presenting an approach to developing a preliminary performance model based on the performance.
Validation of the general purpose QUANTA ®3.2/CHARMm® force field (1992)

Abstract An evaluation of the CHARMm force field for small molecules is described. Using different force field conditions and computational techniques, a wide variety of compounds are analyzed. rms deviations of Cartesian coordinates for 49 diverse organic molecules taken from the Cambridge Crystallographic Data Base and internal coordinate geometries for 28 other molecules are reported. Results are described with different dielectrics, dihedral constraints, and crystal packing to allow analysis of deviations from experimental data and give precise statements of the reliability of the parameters used in the force field. Torsional barriers (rms = 0.4) and conformational energy differences (rms = 0.4) are examined and comparisons made to other force fields such as MM2, Tripos, and DREIDING. The results confirm that CHARMm is an internally consistent all purpose force field with energy terms for bonds, angles, dihedrals, and out‐of‐plane motions, as well as nonbonded electrostatic and van der Waals interactions. Reported CHARMm results (rms = 0.006 Å for bonds, rms = 1.37° for angles, and rms = 3.2° for dihedrals) are in excellent agreement with high quality electron diffraction data. © 1992 by John Wiley & Sons, Inc.
Theoretical and Experimental Study on Oil-Water Two-Phase Flow in a Downhole Venturi Meter (2012)

This paper presents a study on an oil-water two-phase flow model in a downhole Venturi meter by theoretical calculation, numerical simulation and experimental testing. The flow field and pressure characteristics with different flow and oil-water ratios in Venturi tube are investigated. It is found that the flow is stratified in the Venturi tube, the water phase accumulates in the tube center and the oil phase concentrates on the wall; the pressure drop is increased with flow; theoretical and numerical results are verified by experimental data.
掌上娱乐先锋——诺基亚N-Gage试用报告 (2004)

虽然手机整合其它功能已经似乎是习以为常，但第一款真正意义上的手机和掌上游戏机的整合产品——N-Gage的出现还是在业界引起了不小的震动，因为它标志着手机行业开始将它强大的触角伸进了年利润高达300亿美元的游戏产业。面对诺基亚的大力推广，肯定和置疑也在如潮水般涌来，毕竟
Synthesis of (E,E)-thia-4,7-cyclodecadiene and its 3-methyl derivative from D-mannitol. Stereochemical and conformational behavior (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (E,E)-thia-4,7-cyclodecadiene and its 3-methyl derivative from D-mannitol. Stereochemical and conformational behaviorVanda Cere, Claudio Paolucci, Salvatore Pollicino, Edda Sandri, Lodovico Lunazzi, and Antonino FavaCite this: J. Org. Chem. 1982, 47, 18, 3540–3544Publication Date (Print):August 1, 1982Publication History Published online1 May 2002Published inissue 1 August 1982https://pubs.acs.org/doi/10.1021/jo00139a031https://doi.org/10.1021/jo00139a031research-articleACS PublicationsRequest reuse permissionsArticle Views534Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Asymmetric Catalysis. Part 33. New Optically Active Phospholanes Derived from Tartaric Acid. (1988)

Abstract Reaction of the 1,4‐ditosylates (I) with NaPH 2 (II) or dilithium phenylphosphide (IV) gives the cyclic phosphines (III) or (V).
Embodied conversational agents: representation and intelligence in user interfaces (2001)

How do we decide how to represent an intelligent system in its interface, and how do we decide how the interface represents information about the world and about its own workings to a user? This article addresses these questions by examining the interaction between representation and intelligence in user interfaces. The rubric representation covers at least three topics in this context: (1) how a computational system is represented in its user interface, (2) how the interface conveys its representations of information and the world to human users, and (3) how the system's internal representation affects the human user's interaction with the system. I argue that each of these kinds of representation (of the system, information and the world, the interaction) is key to how users make the kind of attributions of intelligence that facilitate their interactions with intelligent systems. In this vein, it makes sense to represent a systmem as a human in those cases where social collaborative behavior is key and for the system to represent its knowledge to humans in multiple ways on multiple modalities. I demonstrate these claims by discussing issues of representation and intelligence in an embodied conversational agent -- an interface in which the system is represented as a person, information is conveyed to human users by multiple modalities such as voice and hand gestures, and the internal representation is modality independent and both propositional and nonpropositional.
Hyaluronic Acid Binding Peptides Prevent Experimental Staphylococcal Wound Infection (2006)

Staphylococcus aureus is a major cause of surgical wound infections. The development of mechanisms of antimicrobial resistance by this and other bacterial pathogens has prompted the search for new approaches to treat infectious diseases. Hyaluronic acid binding peptides have been shown to modulate cellular trafficking during host responses and were assessed for their ability to treat and possibly prevent experimental surgical wound infections caused by S. aureus. Treatment with these peptides was highly efficacious in reducing the number of S. aureus cells at the wound site and ameliorated the inflammatory host response associated with these infections. These data suggest a novel approach for the treatment and prophylaxis of staphylococcal wound infections in the clinical setting.
Towards Modeling Revision Requirements in wikiHow Instructions (2020)

wikiHow is a resource of how-to guides that describe the steps necessary to accomplish a goal. Guides in this resource are regularly edited by a community of users, who try to improve instructions in terms of style, clarity and correctness. In this work, we test whether the need for such edits can be predicted automatically. For this task, we extend an existing resource of textual edits with a complementary set of approx. 4 million sentences that remain unedited over time and report on the outcome of two revision modeling experiments.
Defects pattern recognition for flip chip solder joint quality inspection with laser ultrasound and interferometer (2003)

A defects pattern recognition system has been developed for the flip chip solder joint quality inspection by using laser ultrasound and interferometric techniques. This system extracts Error Ratio and dominant frequency as features from ultrasound waveforms. It also performs a cluster analysis of those feature vectors by applying probabilistic neural network classification algorithm. The system can automatically classify chips into different clusters, therefore can find differences between good and bad chips, as well as classifying the type of defect.
Current inversion impedance converter using operational amplifiers (1976)

A current inversion impedance converter that requires three amplifiers is presented. The residual error in the g parameters is negligible for practical applications. The network is short circuit stable at one port and open circuit stable at the other. A novel application of the circuit is also briefly described.
<title>Printer-related color processing techniques</title> (1995)

This paper reviews the color image processing techniques used in the printing industry for the color space transformation. Generally, the techniques can be classified as the color mixing models, multiple regression, 3D lookup table (LUT) with interpolation, neural network, and fuzzy logic. The following techniques are briefly discussed. (1) Color mixing models such as the Neugebauer equations, Yule-Nielsen model, Clapper-Yule model, Beer-Bouguer law, and Kubelka-Munk theory. (2) Multiple regression. (3) 3D LUT with four geometric interpolations - trilinear, prism, pyramid, and tetrahedral. (4) Artificial neural networks of the multilayer feed-forward and cascade correlation nets. (5) Fuzzy logic. These techniques are compared, whenever possible, with respect to the accuracy, memory requirement, speed, and computational cost.
Switching with photodiodes (1980)

Optoelectronic switches have demonstrated isolation in excess of 80 dB between 2 MHz and 1 GHz, and promise even better performance. The concept of optoelectronic switching is outlined and its physical basis in photodiodes is explored. A model for switching in p-i-n and avalanche photodiodes that agrees very well with observed performance is developed. On the basis of this model, the potential of the technique is assessed for near term and future applications.
An <i>HLA-DRB1</i> –Coded Signal Transduction Ligand Facilitates Inflammatory Arthritis: A New Mechanism of Autoimmunity (2012)

Particular alleles of HLA contribute to disease susceptibility and severity in many autoimmune conditions, but the mechanisms underlying these associations are often unknown. In this study, we demonstrate that the shared epitope (SE), an HLA-DRB1-coded sequence motif that is the single most significant genetic risk factor for erosive rheumatoid arthritis, acts as a signal transduction ligand that potently activates osteoclastogenesis, both in vitro and in vivo. The SE enhanced the production of several pro-osteoclastogenic factors and facilitated osteoclast (OC) differentiation in mouse and human cells in vitro. Transgenic mice expressing a human HLA-DRB1 allele that code the SE motif demonstrated markedly higher propensity for osteoclastogenesis and enhanced bone degradation capacity ex vivo. In addition, the SE enhanced the differentiation of Th17 cells expressing the receptor activator for NF-κB ligand. When the two agents were combined, IL-17 and the SE enhanced OC differentiation synergistically. When administered in vivo to mice with collagen-induced arthritis, the SE ligand significantly increased arthritis severity, synovial tissue OC abundance, and bone erosion. Thus, the SE contributes to arthritis severity by activating an OC-mediated bone-destructive pathway. These findings suggest that besides determining the target specificity of autoimmune responses, HLA molecules may influence disease outcomes by shaping the pathogenic consequences of such responses.