gebhart/patrepeval huggingface dataset:
Synthesis and Structure−Activity Relationships of a New Series of Retinoid-Related Biphenyl-4-ylacrylic Acids Endowed with Antiproliferative and Proapoptotic Activity (2005)

Atypical retinoids (AR) represent a class of proapoptotic agents with promising potential in the treatment of neoplastic diseases. In the present work 4'-hydroxybiphenyl-4-ylacrylic acids were studied as a novel series of AR. The synthesized compounds were evaluated for their antiproliferative activity in a human promyelocytic leukemia cell line (NB4) and in an ovarian carcinoma cell system including IGROV-1, carrying a functional wild-type p53, and a cisplatin-resistant subline, IGROV-1/Pt-1. The presence of a bulky lipophilic group at position 3' (adamantan-1-yl being the best) and the E configuration of the acrylic moiety appear essential for activity below 1 muM. No substitution on the rings or on the double bond improved the activity. A qualitative correlation between the log P and molecular volume of the 3'-substituent and the antiproliferative activity was found. From the study of a few selected compounds, it appears that the presence of the carboxylic group is an essential requirement for apoptogenic properties but not for antiproliferative activity, this being maintained in amide derivatives. On the other hand, compounds able to induce apoptosis produced a detectable level of genotoxic damage. This observation supports the hypothesis that the genotoxic stress is a critical event mediating apoptosis induction by compounds of this class. Among the compounds investigated, E-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid (2) was chosen for further investigation.
Universal fault tolerant quantum computation on bilinear nearest neighbor arrays (2008)

Assuming an array that consists of two parallel lines of qubits and that permits only nearest neighbor interactions, we construct physical and logical circuitry to enable universal fault tolerant quantum computation under the $[[7,1,3]]$ quantum code. A rigorous lower bound to the fault tolerant threshold for this array is determined in a number of physical settings. Adversarial memory errors, two-qubit gate errors and readout errors are included in our analysis. In the setting where the physical memory failure rate is equal to one-tenth of the physical gate error rate, the physical readout error rate is equal to the physical gate error rate, and the duration of physical readout is ten times the duration of a physical gate, we obtain a lower bound to the asymptotic threshold of $1.96\times10^{-6}$.
Estimating Effects of Highway Noise on the Avian Auditory System (2005)

Our own common experience suggests that the adverse effects of noise on birds can be considered with regard to four potentially overlapping categories. First, noise might be annoying to birds. This may cause them to abandon a particular site that is otherwise ideal in terms of food availability, breeding opportunities, etc. Second, noise which lasts for very long periods of time can be stressful. Such noise levels can raise the level of stress hormones, interfere with sleep and other activities, etc. Thirdly, very intense noise (acoustic overexposure) can cause permanent injury to the auditory system. Finally, noise can interfere with acoustic communication by masking important sounds or sound components. The first two categories of investigation are probably best addressed by field experiments. The second two categories of effects are probably best addressed by laboratory experiments where precise control can be obtained. The results of some of these experiments are described in this paper.
Fatty acids in honeybee-collected pollens from six endemic Western Australian eucalypts and the possible significance to the Western Australian beekeeping industry (2002)

Western Australian eucalypt pollens in this research have low levels of lipid (0.59–1.9%) when compared with many other plant species that have evolved alongside the European honeybee. Eucalypt-pollen lipid was dominant in linoleic acid (35.7–48%). The six other major fatty acids that were present in the lipid were myristic, palmitic, stearic, oleic, linolenic and arachidic acids. Linoleic acid was dominant in eucalypt pollen at average concentrations of 2.77–5.81 mg/g pollen. These results could be of significance to the Australian beekeeping industry in refining disease-management strategies in the light that other researchers have found that 2 economically damaging bee diseases (EFB and AFB) are inhibited by certain concentrations of the acid. Redgum- or marri ( Corymbia calophylla )-pollen lipid was also dominated by 2 other known antibacterial fatty acids: myristic (0.25 mg/g pollen) and linolenic (1.06 mg/g pollen), when compared with the other eucalypts studied.
Modulation of the Biological Properties of Aspirin by Formation of a Bioorganometallic Derivative (2008)

Beyond treating headaches: The derivatization of biologically active compounds by organometallic units modulates their pharmacological properties. In studies of antitumor-related biochemical properties, the Co2(CO)6 derivative of aspirin 1 shows significantly modified influence on several relevant pathways, which might be based on an altered interaction with the target enzyme COX-2. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A light sheet confocal microscope for image cytometry with a variable linear slit detector (2016)

We present a light sheet confocal microscope (LSCM) capable of high-resolution imaging of cell suspensions in a microfluidic environment. In lieu of conventional pressure-driven flow or mechanical translation of the samples, we have employed a novel method of fluid transport, redox-magnetohydrodynamics (redox-MHD). This method achieves fluid motion by inducing a small current into the suspension in the presence of a magnetic field via electrodes patterned onto a silicon chip. This on-chip transportation requires no moving parts, and is coupled to the remainder of the imaging system. The microscopy system comprises a 450 nm diode 20 mW laser coupled to a single mode fiber and a cylindrical lens that converges the light sheet into the back aperture of a 10x, 0.3 NA objective lens in an epi-illumination configuration. The emission pathway contains a 150 mm tube lens that focuses the light onto the linear sensor at the conjugate image plane. The linear sensor (ELiiXA+ 8k/4k) has three lateral binning modes which enables variable detection aperture widths between 5, 10, or 20 μm, which can be used to vary axial resolution. We have demonstrated redox-MHD-enabled light sheet microscopy in suspension of fluorescent polystyrene beads. This approach has potential as a high-throughput image cytometer with myriad cellular diagnostic applications.
Systemic Therapy for Merkel Cell Carcinoma: What’s on the Horizon? (2014)

Merkel cell carcinoma is an aggressive neuroendocrine skin cancer that usually affects elderly patients. Despite being uncommon, incidence has been steadily increasing over the last two decades, likely due to increased awareness, better diagnostic methods and aging of the population. It is currently one of the most lethal cutaneous malignancies, with a five-year overall survival of approximately 50%. With the better understanding of the molecular pathways that lead to the development of Merkel cell carcinoma, there has been an increasing excitement and optimism surrounding novel targeted therapies, in particular to immunotherapy. Some of the concepts surrounding the novel targeted therapies and currently ongoing clinical trials are reviewed here.
Path Computation Element Communication Protocol (PCECP) Specific Requirements for Inter-Area MPLS and GMPLS Traffic Engineering (2007)

For scalability purposes, a network may comprise multiple Interior
Gateway Protocol (IGP) areas. An inter-area Traffic Engineered Label
Switched Path (TE-LSP) is an LSP that transits through at least two
IGP areas. In a multi-area network, topology visibility remains local
to a given area, and a head-end Label Switching Router (LSR) cannot
compute an inter-area shortest constrained path. One key application
of the Path Computation Element (PCE)-based architecture is the
computation of inter-area TE-LSP paths. The PCE Communication Protocol
(PCECP) is used to communicate computation requests from Path
Computation Clients (PCCs) to PCEs, and to return computed paths in
responses. This document lists a detailed set of PCECP-specific
requirements for support of inter-area TE-LSP path computation. It
complements the generic requirements for a PCE Communication Protocol.
This memo provides information for the Internet community.
Internet pricing and prioritization (2002)

Considers the problems of Internet congestion and delays from an economic viewpoint and proposes a solution that properly aligns the economic incentives for both users and providers. As currently structured, economic incentives do not promote efficient usage. Furthermore, the current structure does not provide any incentive for service providers to increase capacity, and it does not allow them to provide the better-quality service that many users would be willing to pay for. We develop a properly incentivized economic scheme and an implementation strategy, taking into account the operational details of the medium and the realities of the market. The performance of the proposed plan is analyzed according to queuing theory, producing promising results.
Adventures in pharmacology, aspirin, prostacyclin and nitric oxide. (1997)

OBJECTIVE To study the relationship between hypertensive left ventricular hypertrophy (LVH) in very old patients (> or = 80 years) with neuro-hormonal factors and ventricular arrhythmias. METHODS Heart rate variation, plasma renin (Ren), angiotensin-II (AT-II), aldosterone (Ald), insulin (Ins), Holter and ambulatory blood pressure monitoring were measured in 60 cases (> or = 80 years) which were divided into 2 groups: 30 with primary hypertension accompanied LVH in very old patients (group A); 30 with simple primary hypertension (group B). RESULTS There was no significant difference of AT-II and Ren between group A and B (P > 0.05); Ins and Ald values in group A was much higher than in group B (P all < 0.01); the data of heart rate variability, including very low frequency (VLF) and low frequency (LF) and LF/HF (high frequency) in group A were significantly higher than in group B (P < 0.01, < 0.05, < 0.05, respectively); incidence of premature ventricular contractions (PVC) and myocardial ischaemia in group A were higher than in group B patients. CONCLUSIONS Sympathetic nerve excitability in group A was greatly increased; hypertensive LVH was closely associated with Ald and Ins level, but not with AT-II and Ren. Group A is characterized by a significantly greater frequency of premature ventricular contractions and ischaemia.
Analysis of Arc-Electrode Capacitive Sensors for Characterization of Dielectric Cylindrical Rods (2011)

An arc-electrode capacitive sensor has been developed for quantitative characterization of permittivity of cylindrical dielectric rods. The material property of the cylindrical test piece can be inversely determined from the sensor output capacitance based on a theoretical model. For the modeling process, the electrostatic Green's function due to a point source exterior to a dielectric rod is derived. The sensor output capacitance is numerically calculated using the method of moments (MoM), in which the integral equation is set up based on the electrostatic Green's function. Numerical calculations on sensor configuration optimization are performed. Calculations also demonstrate the quantitative relationship between the sensor output capacitance and the test-piece dielectric and structural properties. Capacitance measurements on different dielectric rods with different sensor configurations have been performed to verify the validity of the numerical model. Very good agreement (to within 3%) between theoretical calculations and measurement results is observed.
Influence of high-resistance and high-velocity training on sprint performance (1995)

The purpose of this study is to analyze the effect of high-resistance (HR) and high-velocity (HV) training on the different phases of 100-m sprint performance. Two training groups (HR and HV) were compared with two control groups (RUN and PAS). The HR (N = 22) and HV group (N = 21) trained 3 d.wk-1 for 9 wk: two strength training sessions (HR or HV) and one running session. There was a run control group (RUN, N = 12) that also participated in the running sessions (1 d.wk-1) and a passive control group (PAS, N = 11). Running speed over a 100-m sprint was recorded every 2 m. By means of a principal component analysis on all speed variables, three phases were distinguished: initial acceleration (0-10 m), building-up running speed to a maximum (10-36 m), and maintaining maximum speed in the second part of the run (36-100 m). HV training resulted in improved initial acceleration (P < 0.05 compared with RUN, PAS, and HR), a higher maximum speed (P < 0.05 compared with PAS), and a decreased speed endurance (P < 0.05 compared to RUN and PAS). The HV group improved significantly in total 100 m time (P < 0.05 compared with the RUN and PAS groups). The HR program resulted in an improved initial acceleration phase (P < 0.05 compared with PAS).
Improving the Thermodynamic Stability of Aluminate Spinel Nanoparticles with Rare Earths (2016)

Surface energy is a key parameter to understand and predict the stability of catalysts. In this work, the surface energy of MgAl2O4, an important base material for catalyst support, was reduced by using dopants prone to form surface excess (surface segregation): Y3+, Gd3+, and La3+. The energy reduction was predicted by atomistic simulations of spinel surfaces and experimentally demonstrated by using microcalorimetry. The surface energy of undoped MgAl2O4 was directly measured as 1.65 ± 0.04 J/m2 and was reduced by adding 2 mol % of the dopants to 1.55 ± 0.04 J/m2 for Y-doping, 1.45 ± 0.05 J/m2 for Gd-doping, and 1.26 ± 0.06 J/m2 for La-doping. Atomistic simulations are qualitatively consistent with the experiments, reinforcing the link between the role of dopants in stabilizing the surface and the energy of segregation. Surface segregation was experimentally assessed using electron energy loss spectroscopy mapping in a scanning transmission electron microscopy image. The reduced energy resulted in coarsening inhibition for the doped samples and, hence, systematically smaller particle sizes (larger surface areas), meaning increased stability for catalytic applications. Moreover, both experiment and modeling reveal preferential dopant segregation to specific surfaces, which leads to the preponderance of {111} surface planes and suggests a strategy to enhance the area of desired surfaces in nanoparticles for better catalyst support activity.
Myofibroblast Involvement in the Allergen-Induced Late Response in Mild Atopic Asthma (1997)

We undertook a detailed cellular and ultrastructural examination of bronchial biopsies from seven allergic asthmatic patients and 10 nonasthmatic control subjects (five atopic and five nonatopic) to determine the nature of the inflammation that occurs during allergen-induced late-phase responses (LPRs). The asthmatic subjects had mild asthma (FEV1 = 94 +/- 9% predicted; mean +/- SEM) and required only intermittent use of beta 2-agonists. Airway mucosal biopsy specimens were obtained on a single occasion from the nonasthmatic controls and on two occasions from the asthmatic subjects, at 24 h after diluent challenge and 24 h after challenge with allergen 3 wk later. The mean maximal decrease in FEV1 during the late response after allergen challenge was 30%, and that after administration of diluent was 4%. In coded plastic sections, subepithelial cells were counted with both light and electron microscopy, and the numbers present were expressed per 0.1 mm2 of tissue. Light microscopy revealed statistically significant increases in the total number of inflammatory cells (P < 0.02) and in "activated fibroblasts" after allergen challenge (P < 0.05). Electron microscopy showed significant increases after allergen challenge in the total number of eosinophils (P < 0.05) and cells with the ultrastructural features of myofibroblasts. The latter cells constituted 1.5% of cells after administration of diluent, and this increased to 15.5% after allergen challenge (P < 0.05). Mast cells were significantly more abundant in the atopic nonasthmatic controls than in the asthmatic subjects after allergen challenge. The study demonstrates that the profile of inflammatory cells in asthma at 24 h after allergen challenge is distinct from that in stable asthma and in nonasthmatic controls, and that migratory cells with a contractile phenotype appear in greater numbers in the late response. We propose that subjects who repeatedly develop a late response have increased numbers of migrating, contractile cells that may contribute to formation of the increased bronchial smooth-muscle mass observed in fatal asthma.
Porous polymer monolith assisted electrospray from a glass microdevice (2005)

The coupling of a lab-on-a-chip microfluidic device to a nanoelectrospray ionization mass spectrometer has the potential to automate many routine analytical procedures and produce a powerful analytical tool. However, past coupling strategies have relied on complex manufacturing steps including drilling and etching the device to attach a capillary or building a nanospray emitter directly into the device. This study shows that a nanospray emitter can be easily fabricated using a porous polymer monolith (PPM) at the end of a glass microdevice. These devices are able to obtain a stable electrospray at a variety of flow rates (50-500 nL/min) but optimal results are obtained at lower flow rates (50-100 nL/min) compatible with electroosmotic flow processes. The PPM is photo-patterned so that it can be placed in any position within the channel of the device with no dead volume. The porous character and the hydrophobic nature of the PPM both aid in development of a stable electrospray process. Total ion current traces for the constant infusion of leucine-enkephalin and PPG show relative standard errors as low as 4%, and produce mass spectra with good signal-to-noise (S/N 43) from only 2 fmol of material. In addition, multiple experiments in a given day show good repeatability with variability as low as 13%, and the multiple flow paths inherent in the PPM limit sprayer clogging.
A broadband CPW-to-microstrip via-less transition for on wafer package probing applications (2003)

A broadband CPW to microstrip via-less transition is proposed and the optimal design is discussed. Simulation and measurement results are given. The results of the transition as multiline TRL calibration standards are presented.
Estimation of Solar Energy Harvested for Autonomous Jellyfish Vehicles (AJVs) (2011)

There is significant interest in harvesting ocean energy for powering the autonomous vehicles that can conduct surveillance for long durations. In this paper, we analyze the applicability of solar cells as a power source for medusa-inspired biomimetic vehicles. Since these vehicles will be operating under ocean waters and may need to dive at various depths, a systematic investigation was conducted to determine the variation of output power as a function of depth and salinity levels. We modeled solar energy harvested by flexible amorphous solar cell coated jellyfish vehicles by considering the variables bell diameter, turbidity, depth, and fineness ratio. Low fineness ratio shapes were found to be better for solar energy powered vehicles. Study of three representative species, Aurelia aurita (AA), Mastigias sp., and Cyanea capillata indicates that harvested power was proportional to bell diameter. Optimum power can be harvested by tilting the vehicle axis to face refracted sunrays. Depending on a swimming pattern, power harvested in charging mode and in propulsion mode could vary significantly. The model indicates that, under some circumstances, amorphous silicon solar cell may be a cost-effective way to power autonomous underwater vehicles (AUVs) operating in shallow-water conditions with large lateral travel distances.
Hierarchical web image classification by multi-level features (2003)

The hierarchical image classification of web content is still an open issue. In this paper, we address the problem of image classification by using not only low-level perceptual features but also high-level semantics features. We focus on the robustness and efficiency of image classification by different categorization methods on different feature sets. Our experiments reveal some characteristics in the hierarchy classification based on textual and visual features. We propose a hierarchical threshold strategy based on data structure for multi-class categorization. The evaluation results are reported and discussed.
What are the major arguments in favour of the genetic susceptibility for inflammatory bowel disease? (2003)

Epidemiological data, notably concordance rates in twin pairs and familial aggregation, have provided strong evidence for the importance of the genetic contribution in inflammatory bowel diseases. Genome wide scanning has been remarkably successful in identifying a number of susceptibility loci. The identification of the IBD1 gene on chromosome 16 as NOD2/CARD15 definitely establishes that a significant proportion of Crohn's disease has an underlying genetic cause. In addition, our knowledge of the clinical impact of other genes in modelling disease phenotypes has increased in parallel. These results have led to great optimism that important clinical applications will result from genetic research in the near future.
Long‐lived polymer radicals. IV. Reactions of poly(<i>N</i>‐methylacrylamide) and poly(<i>N</i>‐methylmethacrylamide) radicals with binary mixtures of vinyl monomers (1983)

Abstract N ‐methylacrylamide (NMAAm) and N ‐methylmethacrylamide (NMMAm) were polymerized to give polymer microspheres containing living propagating radicals. The microsphere polymer radicals were allowed to react with some binary mixtures of vinyl monomers including alternating copolymerization combinations. The reaction processes were investigated by ESR spectroscopy. In the poly(NMMAm) radical/methyl methacrylate (MMA)/styrene (St) system, the propagating radical from MMA was mainly observed at the higher MMA concentration, while polySt radical prevailed at the lower MMA concentration. In the poly(NMMAm) radical/α‐methylstyrene (α‐MeSt)/diethyl fumarate system, the α‐MeSt radical was exclusively observed, while the maleic anhydride (MAn) radical was predominantly observed in the α‐MeSt/MAn system. In the MAn/diphenylethylene system, the propagating radicals from both monomers were observed at comparable concentrations. The poly(NMAAm) microsphere radical behaved differently in the reaction with the MMA/St mixture. The poly(NMAAm) microsphere was found to incorporate preferentially St, leading to formation of the St radical. The St preference was enhanced in the St/cyclohexyl methacrylate (CHMA) system. These results were in agreement with those of block copolymerization via the reaction of poly(NMAAm) radical with the MMA/St or CHMA/St mixture, where the compositions of the resulting polymers were analyzed by pyrolysis gas chromatography.