gebhart/patrepeval huggingface dataset:
Relative electrophysiological potencies of quinidine, 3-OH quinidine and quinidine-N-oxide in guinea-pig heart. (1989)

The relative potencies of the quinidine metabolites, 3-OH quinidine (3OHQ) and quinidine-N-oxide (QNO), to their parent drug, quinidine, were obtained electrophysiologically using guinea-pig hearts. The items examined were QT interval of local extracellular electrogram in a Langendorff's perfused heart, effective refractory period (ERP) and action potential duration at 90% repolarization (APD90) in the right papillary muscle. Quinidine (0.125-1 mg/l) and 3OHQ (0.5-4 mg/l) prolonged QT interval in a concentration-dependent manner and the relative potency of 3OHQ to quinidine was 0.25. The effect of QNO on QT interval within the range of concentration used (up to 8 mg/l) was small and the relative potency was 0.04 at the most. An apparent additive effect of 3OHQ to that of quinidine was revealed, but QNO of 4 mg/l has no effect on the concentration-effect relationship of quinidine for prolonging QT interval. These results were quite similar to those in humans reported previously. Quinidine (0.5-4 mg/l), 3OHQ (1-8 mg/l) and QNO (2-8 mg/l) prolonged APD90 in a concentration-dependent manner. These effects were accompanied by the prolongation of ERP in similar degrees. The relative potencies of 3OHQ to Q were 0.22 for APD90 and 0.27 for ERP and those of QNO were 0.087 for APD90 and 0.084 for ERP. Quinidine (10(-5) M) depressed the maximum upstroke of action potential (Vmax) in a frequency-dependent manner. 3OHQ of the same concentration also depressed it in the same manner to a much lesser extent and QNO had no effect. In conclusion, relative potencies of quinidine metabolites to quinidine for prolonging QT interval of local extracellular electrogram represent those to prolong APD90 and ERP, suggesting the relative potencies for antiarrhythmic activity in the same order. In the physiological range of concentrations of metabolites, 3OHQ may contribute to the antiarrhythmic effect of quinidine in an additive way, but QNO may have little effect when we take into account the fact that the free fraction of 3OHQ is 2.5 times that of quinidine.
Hermetically Coated Optical Fibers: Hydrogen Permeation And Fatigue Properties (1989)

Hydrogen permeation rates have been measured for fibers coated with a CVD applied amorphous carbon hermetic barrier. The H2 permeation was characterized by measuring optical loss increases at elevated temperatures at both high and low hydrogen pressures. Very low predicted values for the rates of hydrogen permeation over a wide range of operating temperatures were found, with an experimentally determined activation energy of 23.7 kcal/mole. In-situ measurements of loss increases upon exposure to hydrogen have shown the existence of a lag time where no hydrogen reaches the core of the fiber. Fiber strengths for the carbon coated hermetic fibers are typically 500-600 ksi. Fatigue properties are markedly improved by the presence of this type of hermetic coating. Dynamic fatigue results show extremely high n values on the order of 350-1000. Static fatigue tests in 21 ° C air and 50% relative humidity give n values of about 200. This is a great improvement over the fatigue results for non-hermetic fibers which exhibit n values of approximately 20.
Determination of the Distribution of Conduction Velocities in Human Nerve Trunks (1979)

A technique is described which enables the distribution of conduction velocities within the alpha fiber group of an in situ human peripheral nerve trunk to be determined. The technique is based on the analysis of the shape of compound nerve action potentials recorded from surface electrodes and is non-invasive. Velocity distributions calculated for a group of normal adults are presented and represent the first known measurements of this parameter.
Reactivation of the Paternal X Chromosome in Early Mouse Embryos (2004)

It is generally accepted that paternally imprinted X inactivation occurs exclusively in extraembryonic lineages of mouse embryos, whereas cells of the embryo proper, derived from the inner cell mass (ICM), undergo only random X inactivation. Here we show that imprinted X inactivation, in fact, occurs in all cells of early embryos and that the paternal X is then selectively reactivated in cells allocated to the ICM. This contrasts with more differentiated cell types where X inactivation is highly stable and generally irreversible. Our observations illustrate that an important component of genome plasticity in early development is the capacity to reverse heritable gene silencing decisions.
Nonlinear filters: beyond the Kalman filter (2005)

Nonlinear filters can provide estimation accuracy that is vastly superior to extended Kalman filters for some important practical applications. We compare several types of nonlinear filters, including: particle filters (PFs), unscented Kalman filters, extended Kalman filters, batch filters and exact recursive filters. The key practical issue in nonlinear filtering is computational complexity, which is often called "the curse of dimensionality". It has been asserted that PFs avoid the curse of dimensionality, but this is generally incorrect. Well-designed PFs with good proposal densities sometimes avoid the curse of dimensionality, but not otherwise. Future research in nonlinear filtering will exploit recent progress in quasi-Monte Carlo algorithms (rather than boring old Monte Carlo methods), as well as ideas borrowed from physics (e.g., dimensional interpolation) and new mesh-free adjoint methods for solving PDEs. This tutorial was written for normal engineers, who do not have nonlinear filters for breakfast.
Requirements interaction management (2003)

Requirements interaction management (RIM) is the set of activities directed toward the discovery, management, and disposition of critical relationships among sets of requirements, which has become a critical area of requirements engineering. This survey looks at the evolution of supporting concepts and their related literature, presents an issues-based framework for reviewing processes and products, and applies the framework in a review of RIM state-of-the-art. Finally, it presents seven research projects that exemplify this emerging discipline.
A rationale for predicting anterior cruciate graft impingement by the intercondylar roof (1991)

This study was designed to analyze how anterior tibial tunnel placement can result in graft impingement by the intercondylar roof. The relationship of the ACL to the intercondylar roof was studied using magnetic resonance scans. An attempt was made to predict the amount of bone that may need to be removed from the intercondylar roof to prevent impingement on a 10 mm thick ACL graft. Magnetic resonance scans of 19 normal ACLs were analyzed. The amount of bone removal required to correct roof impingement was determined for a graft placed either eccentrically or centrally within the ACL insertion, and within the bulk of the normal ACL fibers. An eccentric tibial tunnel placement required approximately 5 to 6 mm and a central placement required 2 to 3 mm of bone removal from the intercondylar roof to prevent impingement. Placing the graft within the bulk of the ACL fibers, just 3 mm posterior to the center of the ACL insertion, required little bone resection to prevent impingement. To prevent ACL graft impingement, roofplasties need to be performed in both acute and chronic ACL reconstructions if the presently accepted locations for positioning the tibial tunnel are used. A more anteriorly placed tibial tunnel requires more bone removal to prevent roof impingement than a more posteriorly positioned tibial tunnel.
Roll-to-roll atomic layer deposition process for flexible electronics encapsulation applications (2014)

At present flexible electronic devices are under extensive development and, among them, flexible organic light-emitting diode displays are the closest to a large market deployment. One of the remaining unsolved challenges is high throughput production of impermeable flexible transparent barrier layers that protect sensitive light-emitting materials against ambient moisture. The present studies deal with the adaptation of the atomic layer deposition (ALD) process to high-throughput roll-to-roll production using the spatial ALD concept. We report the development of such a process for the deposition of 20 nm thickness Al2O3 diffusion barrier layers on 500 mm wide polymer webs. The process uses trimethylaluminum and water as precursors at a substrate temperature of 105 °C. The observation of self-limiting film growth behavior and uniformity of thickness confirms the ALD growth mechanism. Water vapor transmission rates for 20 nm Al2O3 films deposited on polyethylene naphthalate (PEN) substrates were measured as a function of substrate residence time, that is, time of exposure of the substrate to one precursor zone. Moisture permeation levels measured at 38 °C/90% relative humidity by coulometric isostatic–isobaric method were below the detection limit of the instrument (&lt;5 × 10−4 g/m2 day) for films coated at web moving speed of 0.25 m/min. Measurements using the Ca test indicated water vapor transmission rates ∼5 × 10−6 g/m2 day. Optical measurements on the coated web showed minimum transmission of 80% in the visible range that is the same as the original PEN substrate.
Symptoms and impact of COPD assessed by an electronic diary in patients with moderate-to-severe COPD: psychometric results from the SHINE study (2015)

The eDiary was found to be valid, reliable, and responsive. The high correlations obtained between "shortness of breath" and the ratings of "bother" and "difficulty with activities" confirmed the relevance of this symptom in patients with COPD. Future studies will be required to explore further psychometric properties and their ability to differentiate between COPD treatments.
Profile: David Beale (2005)

David Beale is half way through a PhD in applied chemistry. Alyssa French asks this 'doc in waiting' about science, study and scuba diving.
A Perspective on Future Directions in Intelligent Health Control of Gasturbines and Auxiliaries (1999)

Despite their seemingly impressive claims, current products for Condition Monitoring, Diagnostic and Decision Support Systems (CMD&D) do not provide the reliable bottom line information that end users and operators need. Instead they confuse the issue with gigabytes of logged trends, complex cause-effect matrices, fault signatures etc. The term “Intelligent Health Control” here refers to the next generation of such systems which provide usable information on: • the existence and severity of faults; • how their severity will progress with utilization; • how this progress can be influenced or controlled. In this paper the fundamental shortcomings of current approaches are discussed prior to introducing the basics of Intelligent Health Control in terms of fault models and how they can be used to close the diagnostic, prognostic and intelligent control triangle. The industry will unavoidably shift towards an “information centric” view from the currently predominant “data centric” view. Gigabytes of performance trends will no longer be relevant. Instead, reliable bottom line information will be required on how to minimize or control the costs associated with machinery health degradation or faults. In order to keep the discussion real, the current state of the art of enabling technologies are discussed, including: • Open Information Buses; • Adding real time data server functionality to the control system; • Computational Steering, Human-in-the-Loop Optimization (or semi-automatic problem solving); • Fault Models; • Faster than real time simulation; • Neural Nets.
Active Learning and the Total Cost of Annotation. (2004)

Active learning (AL) promises to reduce the cost of annotating labeled datasets for trainable human language technologies. Contrary to expectations, when creating labeled training material for HPSG parse selection and later reusing it with other models, gains from AL may be negligible or even negative. This has serious implications for using AL, showing that additional cost-saving strategies may need to be adopted. We explore one such strategy: using a model during annotation to automate some of the decisions. Our best results show an 80% reduction in annotation cost compared with labeling randomly selected data with a single model.
Vaccination against Anthrax with Attenuated Recombinant Strains of <i>Bacillus anthracis</i> That Produce Protective Antigen (1999)

The protective efficacy of several live, recombinant anthrax vaccines given in a single-dose regimen was assessed with Hartley guinea pigs. These live vaccines were created by transforming DeltaANR and DeltaSterne, two nonencapsulated, nontoxinogenic strains of Bacillus anthracis, with four different recombinant plasmids that express the anthrax protective antigen (PA) protein to various degrees. This enabled us to assess the effect of the chromosomal background of the strain, as well as the amount of PA produced, on protective efficacy. There were no significant strain-related effects on PA production in vitro, plasmid stability in vivo, survival of the immunizing strain in the host, or protective efficacy of the immunizing infection. The protective efficacy of the live, recombinant anthrax vaccine strains correlated with the anti-PA antibody titers they elicited in vivo and the level of PA they produced in vitro.
Clinical Application of Ambient Ionization Mass Spectrometry (2017)

Ambient ionization allows mass spectrometry analysis directly on the sample surface under atmospheric pressure with almost zero sample pretreatment. Since the development of desorption electrospray ionization (DESI) in 2004, many other ambient ionization techniques were developed. Due to their simplicity and low operation cost, rapid and on-site clinical mass spectrometry analysis becomes real. In this review, we will highlight some of the most widely used ambient ionization mass spectrometry approaches and their applications in clinical study.
A Construction of Self-Tuning PID Control System and Its Application to Temperature Control of a Polystyrene Reactor (1994)

Self-tuning control strategies have been considered for systems with unknown parameters. The rapid progress of digital computer enables us to simulate complex and large-scale systems. Many control techniques have been proposed in order to improve the control performance for discrete-time control systems. However, since these control techniques are too complex, it is usually difficult to apply them to real plants and also difficult to understand a physical meaning of control parameters included in these control systems. On the other hand, PID control methods based on the classical control theory have been used widely for real control systems since they have simple control schemes. Therefore, it is necessary to consider control methods with PID control structure in the discrete-time systems. Many literatures with regard to auto-tuning and self-tuning PID control strategies have been reported up to now. But none of them gives us any results for discrete-time systems with time-delay which takes important roles for the stability of the control system and the good control performance.In this paper, we consider a self-tuning PID control algorithm for a system with a time delay element. This control method has four gains, which are proportional, integral, differential gains and a gain for modifying the reference signal. This method enables us to improve a tracking property for a reference signal in the transient state, and also to guarantee the global stability of the control system. Finally, the effectiveness of this control method is shown by applying the method to a temperature control system of a polystrene reactor. In order to show the effectiveness of this method.
A Web Service for Scholarly Big Data Information Extraction (2014)

The automatic extraction of metadata and other information from scholarly documents is a common task in academic digital libraries, search engines, and document management systems to allow for the management and categorization of documents and for search to take place. A Web-accessible API can simplify this extraction by providing a single point of operation for extraction that can be incorporated into multiple document workflows without the need for each workflow to implement and support its own extraction functionality. In this paper, we describe CiteSeerExtractor, a RESTful API for scholarly information extraction that exploits the fact that there is duplication in scholarly big data and makes use of a near duplicate matching backend. The backend stores previously extracted metadata and avoids extracting metadata from a document if it has already been extracted before. We describe the design, implementation, and functionality of CiteSeerExtractor and show how the duplicate document matching results in a difference of 8.46% in the time required to extract header and citation information from approximately 3.5 million documents compared to a baseline.
Control of Plasmonic Superradiance in Metallic Nanoparticle Assembly by Light-Induced Force and Fluctuations (2012)

The possibility of simultaneous control of the configuration and optical functions of a metallic nanoparticle (NP) assembly by light-induced force (LIF) and thermal fluctuations has been demonstrated on the basis of self-consistent theory of LIF and nonequilibrium dynamics. It has been clarified that the NPs are arranged parallel to the polarization of the focused laser beam under the balance of LIF and the electrostatic repulsive force due to the ions on the surface of NPs. Particularly, in such a NP assembly consisting of high-density NPs, the light-scattering rate (radiative decay) of localized surface plasmon polaritons (LSPPs) can be drastically enhanced to be greater than 100 meV (10 times that of single NPs), and the spectral width is also greatly broadened due to the superradiance effect. The results will provide a foundation of the principles for designing a NP assembly with controllable light scattering for highly efficient broad-band light energy conversion devices.
Diffusion Measurements in Agar Gel (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiffusion Measurements in Agar GelEdward J. Schantz and Max A. LaufferCite this: Biochemistry 1962, 1, 4, 658–663Publication Date (Print):July 1, 1962Publication History Published online1 May 2002Published inissue 1 July 1962https://pubs.acs.org/doi/10.1021/bi00910a019https://doi.org/10.1021/bi00910a019research-articleACS PublicationsRequest reuse permissionsArticle Views2042Altmetric-Citations121LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SHP-2 tyrosine phosphatase in human diseases. (2009)

SHP-2, a ubiquitously expressed Src homology 2 (SH2) domain-containing protein tyrosine phosphatase (PTP), plays a critical role in physiology and disease. SHP-2 has been clearly demonstrated to be an important molecule in various cytoplasmic signal transduction pathways. In addition, emerging evidence indicates that SHP-2 may function in the nucleus and in the mitochondria. However, the signaling mechanisms of SHP-2 are not completely understood. Interestingly, genetic mutations in SHP-2 that either enhance or inactivate its catalytic activity have been identified in human diseases with overlapping phenotypes. In light of this hint given by nature, new cell and animal models now provide the opportunity to uncover how this molecule functions in multiple cellular processes, and more importantly, how its known mutations induce human diseases.
ALTERNATIVE<i>CANDIDA ALBICANS</i>LIFESTYLES: Growth on Surfaces (2005)

Candida albicans, an opportunistic fungal pathogen, causes a wide variety of human diseases such as oral thrush and disseminated candidiasis. Many aspects of C. albicans physiology have been studied during liquid growth, but in its natural environment, the gastrointestinal tract of a mammalian host, the organism associates with surfaces. Growth on a surface triggers several behaviors, such as biofilm formation, invasion, and thigmotropism, that are important for infection. Recent discoveries have identified factors that regulate these behaviors and revealed the importance of these behaviors for pathogenesis.
Handbook of Practical Electronic Circuits (1981)

Handbook of practical electronic circuits , Handbook of practical electronic circuits , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Sequence distribution in poly(dimethylsiloxane-co-methylvinylsiloxanes) (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSequence distribution in poly(dimethylsiloxane-co-methylvinylsiloxanes)Maris J. Ziemelis and John C. SaamCite this: Macromolecules 1989, 22, 5, 2111–2116Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/ma00195a017https://doi.org/10.1021/ma00195a017research-articleACS PublicationsRequest reuse permissionsArticle Views341Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Outliers in clinical chemistry quality-control schemes. (1979)

Results submitted to large-scale quality-control schemes are commonly judged against the mean and standard deviation (SD) of the results from other laboratories. It is desirable to ignore outlying values in estimating this mean and standard deviation, and results more than 2.5 or 3 SD from the mean are commonly rejected. I show that an outlier can so inflate the estimated SD that its presence is not detected by this method. Alternative estimators that are less influenced by outliers are described, and their application to quality-control data is discussed.