gebhart/patrepeval huggingface dataset:
Subtype specific internalization of P2Y<sub>1</sub> and P2Y<sub>2</sub> receptors induced by novel adenosine 5′‐O‐(1‐boranotriphosphate) derivatives (2004)

P2Y-nucleotide receptors represent important targets for drug development. The lack of stable and receptor specific agonists, however, has prevented successful therapeutic applications. A novel series of P-boronated ATP derivatives (ATP-alpha-B) were synthesized by substitution of a nonbridging O at P(alpha) with a BH(3) group. This introduces a chiral center, thus resulting in diastereoisomers. In addition, at C2 of the adenine ring a further substitution was made (Cl- or methylthio-). The pairs of diastereoisomers were denoted here as A and B isomers. Here, we tested the receptor subtype specificity of these analogs on HEK 293 cells stably expressing rat P2Y(1) and rat P2Y(2) receptors, respectively, both attached to the fluorescent marker protein GFP (rP2Y(1)-GFP, rP2Y(2)-GFP). We investigated agonist-induced receptor endocytosis, [Ca(2+)](i) rise and arachidonic acid (AA) release. Agonist-induced endocytosis of rP2Y(1)-GFP was more pronounced for the A isomers than the corresponding B counterparts for all ATP-alpha-B analogs. Both 2-MeS-substituted diastereoisomers induced a greater degree of agonist-induced receptor endocytosis as compared to the 2-Cl-substituted derivatives. Endocytosis results are in accordance with the potency to induce Ca(2+) release by these compounds in HEK 293 cells stably transfected with rP2Y(1). In case of rP2Y(2)-GFP, the borano-nucleotides were very weak agonists in comparison to UTP and ATP in terms of Ca(2+) release, AA release and in inducing receptor endocytosis. The different ATP-alpha-B derivatives and also the diastereoisomers were equally ineffective. Thus, the new agonists may be considered as potent and highly specific agonist drug candidates for P2Y(1) receptors. The difference in activity of the ATP analogs at P2Y receptors could be used as a tool to investigate structural differences between P2Y receptor subtypes.
Effects of vestibular stimulation on acetylcholine release from rat hippocampus: an in vivo microdialysis study (1994)

1. The effects of electrical stimulation to the round window of the inner ear and caloric vestibular stimulation on the in vivo release of acetylcholine (ACh) from rat hippocampus were investigated, using brain microdialysis coupled with high performance liquid chromatography-electrochemical detection. 2. Hippocampal ACh release was increased to 152% of the basal release by 1-Hz, 200-ms, and 500-microA electrical stimulation to the round window. This effect was dependent on current intensity. 3. Microinjection of 6,7-dinitroquinoxaline-2,3-dione (DNQX) (10 nmol/0.2 microliter), an antagonist of the non-N-methyl-D-aspartate (non-NMDA) type of glutamate receptor, into the medial vestibular nucleus blocked the increase of hippocampal ACh release by electrical stimulation to the round window. In contrast, microinjection of DNQX (10 nmol/0.2 microliter) into the ventral cochlear nucleus did not inhibit the increase of hippocampal ACh release by electrical stimulation to the round window. 4. Electrical stimulation of the round window increased histamine release from the medial septum, which is the origin of the hippocampal cholinergic terminals. However, the depletion of neuronal histamine by alpha-fluoromethylhistidine (100 mg/kg ip) did not suppress the vestibular-evoked release of hippocampal ACh. 5. Although caloric stimulation with water at 37 degrees C did not affect the hippocampal ACh release, the release was increased to 131% of the basal release by caloric stimulation with hot water at 45 degrees C and was also increased to 160% of the basal release by caloric stimulation with ice water, suggesting that the changes in activities of vestibular afferents increased the hippocampal ACh release.(ABSTRACT TRUNCATED AT 400 WORDS)
High gain, wide margin Josephson junction OR and AND gates (1981)

A new group of high gain and wide margin Josephson Junction direct coupled isolation devices using a novel amplification scheme is described. The group includes a three Josephson Junction OR (3J/OR) gate and a four Josephson Junction AND (4J/AND) gate. DC threshold curves of both devices have been calculated. The optimized threshold for the 3J/OR shows a 30 percent improvement in margin with respect to that of Direct Coupled Logic (DCL). For the 4J/AND, the gain is improved by a factor of 2 over that of the non-linear current injection interferometer devices and the discrimination between one and two inputs is preserved. Simulations of both the 3J/OR and 4J/AND exhibit approximately square current transfer curves with good input and output isolation. For a fan-in of two and a fan-out of three, the 3J/OR gate gives an average switching delay of 31ps and a power dissipation of 3.6µw, and the 4J/AND gate gives a switching delay of 41ps and a power dissipation of 3.8µw.
Characteristics of a high-current, high-voltage Shockley diode (1970)

This paper describes design, development, characterization, and operation of a two-terminal, high-current, high-voltage silicon four-layer diode. The main feature of this new four-layer diode is a voltage-current characteristic which is, prior to switching, similar to that of an avalanche diode. This property is achieved by short-circuiting one emitter-base junction, resulting in a grid-type emitter geometry. The short-circuiting takes place over the entire device area in order to maintain uniform turn-on and uniform current conduction. Devices switching at 1000 volts or higher, with peak pulse current capability of 1000 amperes or more, are described. To achieve very high switching voltages, the stacking of two or three silicon chips was found to be useful. Extended tests Were performed at various combinations of pulsewidths (0.5 to 12 µs), repetition rates (0.2 to 2000 pulses per second), and operating times (0.1 to 2500 hours). The test circuits and the resulting turn-on and recovery times are summarized, Failure analysis establishes hot spot development or thermal fatigue as possible failure mechanisms. Since series operation of many devices is possible without complicated dividing networks, the complexity of pulse modulator circuitry is reduced, and resonantly charged circuits can exhibit a high degree of operation reliability and temperature insensitivity.
Inhibition of Experimental Dental Caries in the Rat by Fluoride and Iodoacetic Acid (1938)

Sodium fluoride and iodoacteic acid added to a caries-producing diet fed to albino rats diminished greatly the incidence of carious lesions in the molar teeth.
The Natural Food Grade Inhibitor, Lacticin 3147, Reduced the Incidence of Mastitis After Experimental Challenge with Streptococcus dysgalactiae in Nonlactating Dairy Cows (1999)

Lacticin 3147 is a broad-spectrum bacteriocin produced by the food-grade organism Lactococcus lactis. Lacticin 3147 is active at a neutral pH and has been shown to be bactericidal to streptococci and staphylococci in vitro. The effectiveness of an intramammary teat seal formulation, and a teat seal containing lacticin 3147 was evaluated at drying off in 68 uninfected quarters of 18 cows. Following infusion of either teat seal or lacticin 3147 combined with teat seal, a deliberate infection challenge of Streptococcus dysgalactiae (1.5 10 4 cfu per teat) was administered by direct inoculation into the teat sinus. During an 8-d experimental period following inoculation, 61% of control quarters and 6% of the treatment quarters either developed clinical mastitis or were shedding the challenge organism. Randomly amplified polymorphic DNA polymerase chain reaction genetic typing was used to confirm that both the new infections and the bacteria surviving in the teats at the end of the experiment were the challenge strain. The combination of teat seal and lacticin 3147 was well tolerated within the udder and elicited only a temporary increase in somatic cell count to 5.7 10 5 / ml (88 h after infusion) in a previously uninfected lactating udder quarter. Therefore, we concluded that this nonantibiotic approach to mastitis prevention may contribute to a reduction in the routine application of antibiotics at drying off in the future.
Wavelength-multiplexed bit synchronization in optical transmission (2002)

An experiment using wavelength division multiplexing (WDM) for bit synchronization is discussed. At the transmitter, the clock and data bit streams that are generated on lasers of two different wavelengths are wavelength multiplexed together onto the same optical fiber. At the receiver, these signals are wavelength demultiplexed. The demultiplexed clock signal at the receiver is used as a strobe to bit synchronize the incoming data stream. Application of this technique to an experimental photonic switching system is described. Design issues associated with the use of the WDM technique for bit synchronization are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Braiding Majoranas in a five qubit experiment (2016)

Currently, the mainstream approach to quantum computing is through surface codes. One way to store and manipulate quantum information with these to create defects in the codes which can be moved and used as if they were particles. Specifically, they behave as exotic particles known as Majoranas, which are a kind of non-Abelian anyon. By exchanging these particles, important gates for quantum computation can be implemented. Here we investigate the simplest possible exchange operation for two surface code Majoranas. This is found to act non-trivially on only five qubits. The system is then truncated to these five qubits, so that the exchange process can be run on the IBM 5Q processor. The results demonstrate the expected effect of the exchange. This paper has been written in a style that should hopefully be accessible to both professional and amateur scientists.
Efficient detection of empty-result queries (2006)

Frequently encountered in query processing, empty query results usually do not provide users with much useful information. Yet, users might still have to wait for a long time before they disappointingly realize that their results are empty. To significantly reduce such unfavorable delays, in this paper, we propose a novel method to quickly detect, without actual execution, those queries that will return empty results. Our key idea is to remember and reuse the results from previously-executed, empty-result queries. These results are stored in the form of so-called atomic query parts so that the (partial) results from multiple queries can be combined together to handle a new query without incurring much overhead. To increase our chance of detecting empty-result queries with only a limited storage, our method (1) stores the most valuable information about empty-result queries, (2) removes redundant information among different empty-result queries, (3) continuously updates the stored information to adapt to the current query pattern, and (4) utilizes a set of special properties of empty results. We evaluate the efficiency of our method through a theoretical analysis and an initial implementation in PostgreSQL. The results show that our method has low overhead and can often successfully avoid executing empty-result queries.
Mining association rules in tree structured XML data (2009)

XML is increasingly popular for knowledge representations. However, mining association rules from them is a challenging issue since XML data is usually poorly supported by the current database systems due to its tree structure. Several encouraging attempts at developing methods for mining rules in tree dataset have been proposed, but simplicity and efficiency still remain significant impediments for further development. What is needed is a clear and simple methodology for finding the rules that are hidden in the heterogeneous tree data. In this paper, we adjust and fine-tune the label projection method which has been recently published to compute association rules from trees. The suggested approach avoids the computationally intractable problem caused by the number of nodes contained in the tree dataset.
Image filtering using multiresolution representations (1991)

It is shown how multiresolution representations can be used for filter design and implementation. These representations provide a coarse frequency decomposition of the image, which forms the basis for two filtering techniques. The first method, based on image pyramids, is used for approximating the convolution of an image with a given mask. In this technique, a filter is designed using a least-squares procedure based on filters synthesized from the basic pyramid equivalent filters. The second method is an adaptive noise reduction algorithm. An optimally filtered image is synthesized from the multiresolution levels, which in this case are maintained at the original sampling density. Individual pixels of the image representation are linearly combined under a minimum mean square error criterion. This uses a local signal-to-noise ratio estimate to provide the best compromise between noise removal and resolution loss.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mitochondrial bioenergetics and structural network organization (2007)

Mitochondria form a dynamic network, and it remains unclear how the alternate configurations interact with bioenergetics properties. The metabolic signals that link mitochondrial structure to its functional states have not been fully characterized. In this report, we analyze the bidirectional relationships between mitochondrial morphology and function in living human cells. First, we determined the effect of mitochondrial fission on energy production by using small interfering RNA (siRNA) targeting DRP1, which revealed the importance of membrane fluidity on the control of bioenergetics. Second, we followed the effect of rotenone, a specific inhibitor of respiratory chain complex I, which causes large structural perturbations, once a threshold was reached. Last, we followed changes in the mitochondrial network configuration in human cells that had been treated with modulators of oxidative phosphorylation, and in fibroblasts from two patients with mitochondrial disease where the respiratory rate, DeltaPsi and the generation of reactive oxygen species (ROS) were measured. Our data demonstrate that the relationship between mitochondrial network organization and bioenergetics is bidirectional, and we provide a model for analyzing the metabolic signals involved in this crosstalk.
Practical issues related to the application of the electromechanical impedance technique in the structural health monitoring of civil structures: I. Experiment (2008)

The advent of smart materials such as the piezo-impedance transducer (lead zirconate titanate, PZT) and optical fiber (FBG) has ushered in a new era in the field of structural health monitoring (SHM) based on non-destructive evaluation (NDE). So far, successful research and investigations conducted on the electromechanical impedance (EMI) technique employing a piezo-impedance transducer are often laboratory based and mainly theoretical. Real-life application of the technique, especially under harsh environments, has frequently been questioned. In this research project, investigative studies were conducted to evaluate the problems involved in real-life applications of the EMI technique, attempting to reduce the gap between theory and application. This two-part paper presents a series of experimentation (part I) and numerical verification (part II) on various issues related to real-life application, including the durability of PZT transducers, and the effects of bonding and temperature under conceivable nominal construction site conditions. The repeatability of electrical admittance signatures acquired from the PZT patches surface bonded on aluminum structures was found to be excellent up to a period of one and a half years. Experimental investigations revealed that the bonding thickness should preferably be thinner than one-third of the patch to avoid any adverse effect caused by the PZT patch's resonance on the admittance signatures which reflect the host structural behavior. On the other hand, the effect of temperature on the admittance signatures was found to be closely related to the thickness of bonding, as an increase in temperature would reduce the stiffness of the bonding layer, thus affecting strain transfer. It was concluded that PZT patches with thick bonding thickness and high frequency of excitation are undesirable, especially at elevated temperatures.
Evaluation of titanium ultralight manual wheelchairs using ANSI/ RESNA standards. (2008)

Comfortable propulsion and support, light weight, and small dimensions are important features that help preserve upper-limb integrity of manual wheelchair users and improve accessibility. The titanium wheelchair is a product developed in response to these goals, but none of the test results of titanium wheelchairs had been disclosed before this study was performed. We hypothesized that these titanium wheelchairs would be in compliance with American National Standards Institute (ANSI)/Rehabilitation Engineering and Assistive Technology Society of North America (RESNA) standards. We tested 12 ultralight titanium rigid-frame wheelchairs (4 models) using ANSI/RESNA testing procedures and compared the test results with previously tested ultralight and lightweight aluminum wheelchairs. All wheelchairs passed the forward braking effectiveness test, but eight wheelchairs tipped backward before inclining to 7 degrees in the rearward braking effectiveness test. All wheelchairs passed the impact strength tests, but six wheelchairs failed in the static strength tests. Three wheelchairs successfully completed the fatigue tests, but the remaining wheelchairs failed prematurely. This group of titanium wheelchairs had less equivalent cycles and value than the ultralight aluminum wheelchairs that were tested in a previous study. The failure modes revealed important design issues of each model. Our results suggest that manufacturers may need to perform more careful analyses before commercializing new products.
Electrocatalytic detection of cobalt separated by ion exchange chromatography (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrocatalytic detection of cobalt separated by ion exchange chromatographyYoshinori. Takata, Fumio. Mizuniwa, and Chiaki. MaekoyaCite this: Anal. Chem. 1979, 51, 14, 2337–2339Publication Date (Print):December 1, 1979Publication History Published online1 May 2002Published inissue 1 December 1979https://pubs.acs.org/doi/10.1021/ac50050a011https://doi.org/10.1021/ac50050a011research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Role for Substance P–Based Nociceptive Signaling in Progenitor Cell Activation and Angiogenesis During Ischemia in Mice and in Human Subjects (2012)

Our data highlight the role of SP in reparative neovascularization. Nociceptive signaling may represent a novel target of regenerative medicine.
From Photons to Bits (1992)

There are many ways to record optical images. One might describe Paleolithic cave paintings as the earliest imaging technology. As significant as they probably were to those who made and lived with them, these depictions were limited by the artist's skill and time, and only persons who entered the cave could benefit from them. It was not until the coming of the printing press that a particular image could be made available to a wide audience. But even then one was still dependent on the artistic skill and subjective vision of the individual artist.
Identification of QTL controlling post-flowering period in soybean (2012)

The length of the reproductive period affects the grain yield of soybean (Glycine max [L.] Merr), and genetic control of the period might contribute to yield improvement. To detect genetic factor(s) controlling the reproductive period, a population of recombinant inbred lines (RILs) was developed from a cross between Japanese landrace 'Ippon-Sangoh' and, Japanese cultivar 'Fukuyutaka' which differ in their duration from flowering to maturation (DFM) relative to the difference in the duration from sowing to flowering (DSF). In the RIL population, the DFM correlated poorly (r = -0.16 to 0.34) with the DSF in all field trials over 3 years. Two stable QTLs for the DFM on chromosomes (Chr-) 10 and 11 as well as two stable QTLs for the DSF on Chr-10 and -16 were identified. The QTL on Chr-11 for the reproductive period (designated as qDfm1; quantitative trait locus for duration from flowering to maturation 1) affected all three trials, and the difference in the DFM between the Fukuyutaka and Ippon-Sangoh was mainly accounted for qDfm1, in which the Fukuyutaka allele promoted a longer period. qDfm1 affected predominantly the reproductive period, and thus it might be possible to alter the period with little influence on the vegetative period.
QUEUE SPILLOVERS IN TRANSPORTATION NETWORKS WITH A ROUTE CHOICE (1997)

This paper explores some of the traffic phenomena that arise when drivers have to navigate a network in which queues back up past diverge intersections. If a diverge provides two alternative routes to the same destination and the shorter route has a bottleneck that generates a queue, one would expect that queue to stabilize at an equilibrium level where the travel time on both routes is roughly equal. If the capacity of the alternative route is unlimited then this network can accommodate any demand level. However, if the bottleneck is so close to the upstream end of the link that the equilibrium queue cannot be contained in the link, then the trip time on the queued route cannot grow to match that on the alternate route. This means that the alternative route can never be attractive, even if the queue spills back past the diverge, and that drivers approaching the diverge will act as if the alternative route did not exist. As a result, a steady flow into the system greater than the capa...
Chapter V (2008)

<sc>nd</sc> so here’s Rugby, sir, at last, and you’ll be in plenty of time for dinner at the School- house,* as I tell’d you,” said the old guard, pulling...
Synthesis of an <i>N</i>-Mesityl Substituted Chiral Imidazolium Salt for NHC-Catalyzed Reactions (2008)

A new synthetic approach to chiral imidazolium salts makes possible the first synthesis of an N-mesityl substituted, aminoindanol-derived N-heterocyclic carbene precursor, 1.ClO4. The successful synthesis allows the first direct comparison of otherwise identical imidazolium and triazolium precursors across a number of NHC-catalyzed processes. These studies confirm striking differences in reactivity and mechanism between the two classes.