gebhart/patrepeval huggingface dataset:
Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis. (2010)

This study offers further evidence that SETD2 behaves like a tumour suppressor gene. Our hypothesis links SETD2 mode of action with telomerase regulation through human telomerase reverse transcriptase (hTERT). Several studies have emphasised the importance of histone methylation of hTERT promotor in telomerase regulation. SETD2 function of histone methylation could be the missing link in this chain which could explain the potential tumour suppressor function of SETD2.
Exploiting Spatial Variability for Disparity Estimation. (2006)

Abstract—In this correspondence a block-matching strategy for disparity estimation is introduced. In the proposed approach the size of the matching window is adapted according to the spatial variability of the matching areas. That is, the window size is constrained by the variations of the image intensity. A modified semivariogram function is proposed to measure the spatial variability of concerned sampling positions. Results of computer experiments aimed at validating the performance of the proposed approach are reported. As expected, using adaptive matching window size provides better disparity estimations than those obtained by using a fixed window. Index Terms—Adaptive window size, block matching, motion/disparity estimation, semivariogram function.
Phospholamban-to-SERCA2 ratio controls the force-frequency relationship (1999)

The force-frequency relationship (FFR) describes the frequency-dependent potentiation of cardiac contractility. The interaction of the sarcoplasmic reticulum Ca2+-adenosinetriphosphatase (SERCA2) with its inhibitory protein phospholamban (PLB) might be involved in the control of the FFR. The FFR was analyzed in two systems in which the PLB-to-SERCA2 ratio was modulated. Adult rabbit cardiac myocytes were transduced with adenovirus encoding for SERCA2, PLB, and beta-galactosidase (control). After 3 days, the relative PLB/SERCA2 values were significantly different between groups (SERCA2, 0.5; control, 1.0; PLB, 4.5). SERCA2 overexpression shortened relaxation by 23% relative to control, whereas PLB prolonged relaxation by 39% and reduced contractility by 47% (0.1 Hz). When the stimulation frequency was increased to 1.5 Hz, myocyte contractility was increased by 30% in control myocytes. PLB-overexpressing myocytes showed an augmented positive FFR (+78%), whereas SERCA2-transduced myocytes displayed a negative FFR (-15%). A more negative FFR was also found in papillary muscles from SERCA2 transgenic mice. These findings demonstrate that the ratio of phospholamban to SERCA2 is an important component in the control of the FFR.
Leptin Is Present in Human Cord Blood (1997)

It has recently been reported that the ob gene receptor was expressed on human and murine hematopoietic stem cells and that the ob gene product leptin stimulated hemato- and lymphopoiesis at the stem cell level. These findings suggest a role for leptin in hemato- and lymphopoiesis during fetal development. There is at present no evidence, however, that leptin is synthesized and released by the fetus. To investigate this possibility, we have measured plasma leptin concentrations in the cord blood of 78 newborn infants. We found that leptin was present in all 78 infants in concentrations comparable with those found in adults (0.6-55.7 ng/ml). Overall, plasma leptin concentrations in the cord blood of infants correlated with birth weight (r = 0.74, P < 0.001). These observations show that leptin is synthesized and released by fetal fat cells. In addition, they are compatible with the concept that leptin may play a role in human fetal hematopoiesis.
Anatomic Femoral and Tibial Tunnel Placement During Anterior Cruciate Ligament Reconstruction: Anteromedial Portal All‐Inside and Outside‐In Techniques (2017)

Tunnel malposition is one of the most common technical reasons for anterior cruciate ligament reconstruction failure. Small changes in tunnel placement can result in significant differences in outcome. More anatomic placement of the tunnels can lead to greater knee stability and a more accurate reproduction of native knee kinematics. This Technical Note describes 2 tibial tunnel-independent methods to obtain anatomic femoral tunnel placement. The all-inside anteromedial portal technique requires only minimal surgical incisions but allows precise femoral tunnel placement. However, hyperflexion of the knee is required, adequate surgical assistance is necessary, and this technique may be susceptible to graft-tunnel mismatch. The outside-in technique may be more beneficial in obese patients, skeletally immature patients, or revision cases. On the downside, it does require an additional 2-cm surgical incision. This article also provides surgical pearls to fine-tune tibial tunnel placement.
Voltammetric, coulometric, mercury-199 NMR, and other studies characterizing new and unusual mercury complexes produced by electrochemical oxidation of mercury(II) diethyldithiocarbamate. Crystal and molecular structure of octakis(N,N-diethyldithiocarbamato)pentamercury(II) perchlorate (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVoltammetric, coulometric, mercury-199 NMR, and other studies characterizing new and unusual mercury complexes produced by electrochemical oxidation of mercury(II) diethyldithiocarbamate. Crystal and molecular structure of octakis(N,N-diethyldithiocarbamato)pentamercury(II) perchlorateAlan M. Bond, Ray Colton, Anthony F. Hollenkamp, Bernard F. Hoskins, and Katherine McGregorCite this: J. Am. Chem. Soc. 1987, 109, 7, 1969–1980Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/ja00241a012https://doi.org/10.1021/ja00241a012research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Determination of Arabidopsis floral meristem identity by AGAMOUS. (1997)

Determinate growth of floral meristems in Arabidopsis requires the function of the floral regulatory gene AGAMOUS (AG). Expression of AG mRNA in the central region of floral meristems relies on the partially overlapping functions of the LEAFY (LFY) and APETALA1 (AP1) genes, which promote initial floral meristem identity. Here, we provide evidence that AG function is required for the final definition of floral meristem identity and that constitutive AG function can promote, independent of LFY and AP1 functions, the determinate floral state in the center of reproductive meristems. Loss-of-function analysis showed that the indeterminate central region of the ag mutant floral meristem undergoes conversion to an inflorescence meristem when long-day-dependent flowering stimulus is removed. Furthermore, gain-of-function analysis demonstrated that ectopic AG function results in precocious flowering and the formation of terminal flowers at apices of both the primary inflorescence and axillary branches of transgenic Arabidopsis plants in which AG expression is under the control of the 35S promoter from cauliflower mosaic virus. Similar phenotypes were also observed in lfy ap1 double mutants carrying a 35S-AG transgene. Together, these results indicate that AG is a principal developmental switch that controls the transition of meristem activity from indeterminate to determinate.
Enhancement of Adenovirus‐Mediated Gene Transfer into Dermal Fibroblasts <i>In vitro</i> and <i>In vivo</i> by Polyethylene Glycol 6000 (2000)

Gene therapy directed to the skin requires efficient transfer of the desired gene into cutaneous cells. In this study, we examined several chemical substances present in various ointments by enhancement of virus infectivity. The recombinant adenovirus vector, AxCALacZ, was used to infect dermal fibroblasts with some chemicals both in vitro and in vivo, and the expression of the LacZ gene was determined by X-Gal reaction. As the result, it was shown that PEG 6000 had the highest ability to enhance the exogenous gene expression in cultured fibroblasts with little toxicity. In vivo, it was also demonstrated that fibroblasts in mouse skin were efficiently gene transfer by adenovirus vector and 20% PEG 6000-treatment. These results suggest that this chemical treatment appears to be a simple, safe, convenient, and effective method for facilitating virus-mediated gene therapy in the skin.
Comparative Anatomical Study of Ventrolateral Thalamic Mass in Humans and Monkeys (1993)

Cytoarchitecture and enzyme activity in the ventrolateral thalamic mass of humans and monkeys were examined using conventional Nissl, myelin stain and histochemical methods. According to the data obtained from cytometric analysis, the histogram patterns of cell dimensions and cell density in each ventrolateral thalamic nucleus in humans and monkeys were very similar. Moreover, acetylcholinesterase-stained sections revealed a parcellation of the ventrolateral thalamic nuclei that could be correlated with that in the monkey thalamus. Apart from differences of size, the nuclei of the human and monkey thalamus are remarkably similar. We proposed accordingly that a new parcellation of human thalamic nuclei be based on cytometric analysis and histochemical staining.
ConPath: Scaffold Analysis Tool Using Mate-Pair Information for Genome Sequencing (2007)

We have developed a Windows-based program, ConPath, as a scaffold analyzer which constructs scaffolds by ordering and orienting separate sequence contigs by exploiting the mate-pair information between contig-pairs. Our algorithm builds directed graphs from link information and traverses them to find out the longest acyclic graphs. Using end-read pairs of fixed-sized mate-pair library, ConPath determines relative orientations of all contigs, estimates the gap size of each adjacent contig pairs, and reports wrong assembly information by validating orientations and gap sizes. We have utilized ConPath in more than 10 microbial genome projects, including M. succiniciproducens [12] and V.vulinificus, where we have verified contig assembly by finding out some erroneous contigs with four kinds of error types defined in ConPath. It also supports some convenient features and viewers to investigate each contig in detail, like contig viewer, scaffold viewer, edge information list, mate-pair list, printing complex scaffolds structures, and so on.
Influence of a magnesium‐fluoride coating of magnesium‐based implants (MgCa0.8) on degradation in a rabbit model (2010)

MgCa0.8 cylinders (2.5 x 25 mm(2)) were coated with a magnesium-fluoride layer and implanted in the marrow cavities of both tibiae of 10 New Zealand White rabbits. The implantation duration was 3 and 6 months. The implants were clinically well tolerated. Micro-computed tomography revealed a new bone formation at the edges of the implants as well as an endosteal and periosteal remodeling. Using EDX-analysis, a calcium and phosphorus rich degradation layer could be found on the implant surface. It was covered by an incomplete layer containing fluoride. The analysis by weight before implantation and after 3 and 6 months, respectively, showed a slight decrease in volume in comparison to uncoated implants. When compared with uncoated implants, the mechanical properties of the coated implants exhibited a reduction in strength after 3 months. After 6 months, the strength of the coated implants was higher than that of uncoated cylinders.
The synthesis of benzofuroquinolines. VIII. Some halobenzofuro[2,3‐<i>c</i>]quinoline derivatives (1990)

Abstract Three 2‐halo‐6(5 H )‐benzofuro[2,3‐ c ]quinolinones 1 (X = F, Cl, Br) were synthesized in two procedures, photocyclization of N ‐benzyl‐ N ‐( p ‐halophenyl)‐2‐benzofurancarboxamides 3 (X = F, Cl, Br) and condensation of 2‐amino‐2′‐hydroxybenzophenones 7 (X = F, Cl, Br) with chloroacetonitrile. Three 2‐halo‐6‐methylbenzofuro[2,3‐ c ]quinolines 2 (X = F, Cl, Br) were also synthesized by the condensation of 2‐amino‐5‐halo‐2′‐hydroxybenzophenones 7 (X = F, Cl, Br) with chloroacetone.
ChemInform Abstract: Electrophilic Fluorination of Carbon‐Hydrogen Bonds (in Organic Molecules) (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Immunostimulation by a partially modified retro-inverso-tuftsin analog containing Thr1.sum..psi.[NHCO](R,S)Lys2 modification (1991)

The tuftsin retro-inverso analogue H-Thr psi[NHCO](R,S)Lys-Pro-Arg-OH was synthesized through a novel procedure for the high-yield incorporation of isolated retro-inverso bonds into peptide chains and the use of the new Meldrum's acid derivative (CH3)2C(OCO)2CH(CH2)4NHCOCF3 followed by its efficient coupling in solution to trimethylsilylated H-D-Thr(t-Bu)NH2. Closely related peptide impurities were eliminated both from the crude final peptide and the fully protected tetrapeptide amide precursor via ion-exchange and reversed-phase displacement chromatography, respectively. The tuftsin retro-inverso analogue proved to be completely resistant to enzymatic degradation in vitro, either against isolated aminopeptidases or human plasma proteolytic enzymes. When administered either orally or intravenously, it was significantly more active than normal tuftsin in increasing the number of specific antibody secreting cells in spleen of mice immunized with sheep erythrocytes. Furthermore, the analogue exerted an enhanced stimulatory effect on the cytotoxic activity of splenocytes against YAC-1 tumor cells. Finally, retro-inverso-tuftsin was about 10-fold more potent than the native peptide in reducing rat adjuvant arthritis. The resistance of the retro-inverso analogue to peptidases might explain the increased in vivo activities and allows its further immunopharmacological characterization.
Joint maximum a posteriori adaptation of transformation and HMM parameters (2001)

Model adaptation techniques are an efficient way to reduce the mismatch that typically occurs between the training and test condition of any speech recognizer. Adaptation techniques can usually be divided into two families of approaches. On one hand, direct model adaptation attempts to directly reestimate the model parameters, for example using MAP adaptation. Since direct adaptation only reestimates model parameters of the corresponding units appearing in the adaptation data, a large amount of such data is needed to observe any significant improvement in performance. However, nice asymptotic properties are usually observed, meaning that the performance improves as the amount of adaptation data increases. On the other hand, indirect model adaptation applies a general transformation on some clusters of model parameters. Because each individual model is transformed, the approach is quite effective when a small amount of adaptation data is available. However, as the amount of adaptation data increases, the performance improvement quickly saturates. We propose to jointly estimate model parameters and transformation parameters using a single estimation criterion based on Bayesian statistics. We show that by providing a prior distribution for the model parameters and the transformation parameters, it is possible to jointly estimate these two sets of parameters using maximum a posteriori estimation (MAP). Experimental evaluation on nonnative speaker and channel adaptation illustrates the effectiveness of the proposed approach.
A circuit technique to compensate PVT variations in a 28 nm CMOS cascode power amplifier (2015)

This paper presents a method to compensate CMOS process-, voltage-, and temperature (PVT) variations in a linear two-stage RF power amplifier (PA). The proposed circuit technique mitigates bias point fluctuations caused by non-controllable uncertainties like wafer-dependent electron mobility, increasing die temperature due to substrate self-heating, or supply voltage deviations. A scaled PA replica cascode circuit and a controlled current mirror form a feedback loop which stabilizes the PA operation point over a wide range of PVT variations. As demonstrated by simulations and verified by measurements, the PA operating conditions have been stabilized over a temperature range of 90°C and more than 0.5V supply change. The proposed biasing scheme has been implemented using a 28nm standard CMOS process. The PA is able to deliver more than one Watt of RF output power at a peak power-added efficiency (PAE) of 33% at 1.8GHz center frequency operation.
ChemInform Abstract: TRYPANOZIDE DIAMIDINE MIT VIER RINGEN IN EINEM ODER ZWEI RINGSYSTEMEN (1973)

Abstract Die try anoziden Ei enschaften der Diamidine vom Typ (I) werden durch Starrheit des Molekülgerüstes und durch seine Flächenvergrößerung beeinträchtigt, wie die Untersuchung der nach bekannten Methoden dargestellten Diamidine (II)‐(VIII) zeigte.
A cDNA clone encoding HBP-1b homologue in<i>Arabidopsis thaliana</i> (1992)

Journal Article A cDNA clone encoding HBP-1b homologue in Arabidopsis thaliana Get access Takefumi Kawata, Takefumi Kawata 1Division of Developmental Biology, National Institute for Basic BiologyOkazaki 444, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Takuya Imada, Takuya Imada 3Department of Botany, Kyoto UniversityKyoto 606-01, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Hideaki Shiraishi, Hideaki Shiraishi 2Division of Gene Expression and Regulation I, National Institute for Basic BiologyOkazaki 444, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Kiyotaka Okada, Kiyotaka Okada 2Division of Gene Expression and Regulation I, National Institute for Basic BiologyOkazaki 444, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshiro Shimura, Yoshiro Shimura 2Division of Gene Expression and Regulation I, National Institute for Basic BiologyOkazaki 444, Japan4Department of Biophysics, Faculty of Science, Kyoto UniversityKyoto 606-01, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Masaki Iwabuchi Masaki Iwabuchi 1Division of Developmental Biology, National Institute for Basic BiologyOkazaki 444, Japan3Department of Botany, Kyoto UniversityKyoto 606-01, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 20, Issue 5, 11 March 1992, Page 1141, https://doi.org/10.1093/nar/20.5.1141 Published: 11 March 1992 Article history Accepted: 17 January 1992 Published: 11 March 1992
BioSEAL: In-Memory Biological Sequence Alignment Accelerator for Large-Scale Genomic Data (2019)

Genome sequences contain hundreds of millions of DNA base pairs. Finding the degree of similarity between two genomes requires executing a compute-intensive dynamic programming algorithm, such as Smith-Waterman. Traditional von Neumann architectures have limited parallelism and cannot provide an efficient solution for large-scale genomic data. Approximate heuristic methods (e.g. BLAST) are commonly used. However, they are suboptimal and still compute-intensive. In this work, we present BioSEAL, a Biological SEquence ALignment accelerator. BioSEAL is a massively parallel non-von Neumann processing-in-memory architecture for large-scale DNA and protein sequence alignment. BioSEAL is based on resistive content addressable memory, capable of energy-efficient and high-performance associative processing. We present an associative processing algorithm for entire database sequence alignment on BioSEAL and compare its performance and power consumption with state-of-art solutions. We show that BioSEAL can achieve up to 57x speedup and 156x better energy efficiency, compared with existing solutions for genome sequence alignment and protein sequence database search.
The<i>relA/spoT</i>-Homologous Gene in<i>Streptomyces coelicolor</i>Encodes Both Ribosome-Dependent (p)ppGppSynthesizing and -Degrading Activities (1998)

Streptomyces coelicolor (p)ppGpp synthetase (Rel protein) belongs to the RelA and SpoT (RelA/SpoT) family, which is involved in (p)ppGpp metabolism and the stringent response. The potential functions of the rel gene have been examined. S. coelicolor Rel has been shown to be ribosome associated, and its activity in vitro is ribosome dependent. Analysis in vivo of the active recombinant protein in well-defined Escherichia coli relA and relA/spoT mutants provides evidence that S. coelicolor Rel, like native E. coli RelA, is functionally ribosome associated, resulting in ribosome-dependent (p)ppGpp accumulation upon amino acid deprivation. Expression of an S. coelicolor C-terminally deleted Rel, comprised of only the first 489 amino acids, catalyzes a ribosome-independent (p)ppGpp formation, in the same manner as the E. coli truncated RelA protein (1 to 455 amino acids). An E. coli relA spoT double deletion mutant transformed with S. coelicolor rel gene suppresses the phenotype associated with (p)ppGpp deficiency. However, in such a strain, a rel-mediated (p)ppGpp response apparently occurs after glucose depletion, but only in the absence of amino acids. Analysis of ppGpp decay in E. coli expressing the S. coelicolor rel gene suggests that it also encodes a (p)ppGpp-degrading activity. By deletion analysis, the catalytic domains of S. coelicolor Rel for (p)ppGpp synthesis and degradation have been located within its N terminus (amino acids 267 to 453 and 93 to 397, respectively). In addition, E. coli relA in an S. coelicolor rel deletion mutant restores actinorhodine production and shows a nearly normal morphological differentiation, as does the wild-type rel gene, which is in agreement with the proposed role of (p)ppGpp nucleotides in antibiotic biosynthesis.
Advertising and Product Quality: Are Heavily Advertised Products Better? (1976)

It is often conceded that heavily advertised products cost more than those that are not advertised extensively. But there is considerable disagreement concerning what this difference means. Advertising's critics often claim it is evidence of monopolistic control over supply and prices, while advertising's defenders generally contend it reflects the higher quality of advertised brands. Surprisingly, there has been almost no research into whether or not heavily advertised goods are of better quality. As a preliminary inquiry into this interesting question, this paper attempts to examine the relationship between advertising expenditures and product quality.