gebhart/patrepeval huggingface dataset:
Demonstration of complex-conjugate-resolved harmonic Fourier-domain optical coherence tomography imaging of biological samples (2007)

Complex-conjugate-resolved Fourier-domain optical coherence tomography, where the quadrature components of the interferogram are obtained by simultaneous acquisition of the first and second harmonics of the phase-modulated interferogram, is applied to multisurface test targets and biological samples. The method provides efficient suppression of the complex-conjugate, dc, and autocorrelation artifacts. A complex-conjugate rejection ratio as high as 70 dB is achieved.
Analysis of Splice Variants of the Immediate-Early 1 Region of Human Cytomegalovirus (2004)

The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) produces multiple mRNAs through differential splicing and polyadenylation. Reverse transcriptase PCR was used to characterize transcripts from exons 1, 2, 3, and 4 (immediate-early 1 [IE1]). The expected IE72 and IE19 mRNAs were detected, as well as two heretofore-uncharacterized transcripts designated IE17.5 and IE9. The IE72, IE19, and IE17.5 transcripts utilized the same 5'-splice site in exon 3. IE9 utilized a cryptic 5'-splice site within exon 3. The IE19, IE17.5, and IE9 transcripts all used different 3'-splice sites within exon 4. These spliced species occur in infected human foreskin fibroblast (HFF) cells, with accumulation kinetics similar to those of IE72 mRNA. IE19 and IE9 RNAs were much more abundant than IE17.5 RNA. Transfection of CV-1 cells with cDNAs resulted in IE19 and IE17.5 proteins detectable by antibodies to either N-terminal or C-terminal epitopes. No IE9 protein product has been detected. We have not been able to detect IE19, IE17.5, or IE9 proteins during infection of HFF, HEL, or U373MG cells. Failure to detect IE19 protein contrasts with a previous report (M. Shirakata, M. Terauchi, M. Ablikin, K. Imadome, K. Hirai, T. Aso, and Y. Yamanashi, J. Virol. 76:3158-3167, 2002) of IE19 protein expression in HCMV-infected HEL cells. Our analysis suggests that an N-terminal breakdown product of IE72 may be mistaken for IE19. Expression of IE19 or IE17.5 from its respective cDNA results in repression of viral gene expression in infected cells. We speculate that expression of these proteins during infection may be restricted to specific conditions or cell types.
Efficient update data generation for DBMS benchmarks (2012)

It is without doubt that industry standard benchmarks have been proven to be crucial to the innovation and productivity of the computing industry. They are important to the fair and standardized assessment of performance across different vendors, different system versions from the same vendor and across different architectures. Good benchmarks are even meant to drive industry and technology forward. Since at some point, after all reasonable advances have been made using a particular benchmark even good benchmarks become obsolete over time. This is why standard consortia periodically overhaul their existing benchmarks or develop new benchmarks. An extremely time and resource consuming task in the creation of new benchmarks is the development of benchmark generators, especially because benchmarks tend to become more and more complex. The first version of the Parallel Data Generation Framework (PDGF), a generic data generator, was capable of generating data for the initial load of arbitrary relational schemas. It was, however, not able to generate data for the actual workload, i.e. input data for transactions (insert, delete and update), incremental load etc., mainly because it did not understand the notion of updates. Updates are data changes that occur over time, e.g. a customer changes address, switches job, gets married or has children. Many benchmarks, need to reflect these changes during their workloads. In this paper we present PDGF Version 2, which contains extensions enabling the generation of update data.
Projektbericht Vergleichsuntersuchung MESSENGER - FULCRUM (2000)

Available from TIB Hannover: RS 2324(18) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische Informationsbibliothek
Simultaneous loss of bacteriophage receptor and coaggregation mediator activities in Actinomyces viscosus MG-1 (1985)

Actinomyces bacteriophages were used as tools to study coaggregation between actinomyces and streptococci. Four bacteriophage isolates, phages AV-1, AV-2, AV-3, and 1281, bound to coaggregation group A Actinomyces viscosus and to group E A. naeslundii. No binding to groups B, C, D, or F was observed. Only A. viscosus MG-1 was capable of supporting a productive infection by these phages. Spontaneously occurring bacteriophage-resistant mutants of A. viscosus MG-1 were isolated and were shown to fall into two classes. Class I mutants were resistant to all four phages, whereas class II mutants were resistant only to phage AV-3. In each case, strains resistant to a particular phage were unable to bind that phage, suggesting that a loss or alteration of the cell surface phage receptor had occurred. Both classes of mutants were unable to coaggregate with streptococci representing coaggregation group 1 and had also lost the ability to mediate one type of coaggregation with group 4 streptococci. Class II mutants also were unable to coaggregate with group 2 streptococci. Lactose-inhibitable interactions with other streptococci (groups 3 and 4) were unchanged in the mutants. The simultaneous loss of sensitivity to phage AV-3 and the ability to coaggregate with coaggregation group 1 streptococci suggests the possibility of a relationship between these two cell surface structures.
Cycloaddition reactions of cyclopropenones. 4. Reaction of some 2-aminopyridines with methylphenylcyclopropenone (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCycloaddition reactions of cyclopropenones. 4. Reaction of some 2-aminopyridines with methylphenylcyclopropenoneAlbert Kascheres, Concetta Kascheres, J. Augusto R. Rodrigues, and Ana Rita A. SantanaCite this: J. Org. Chem. 1976, 41, 22, 3546–3549Publication Date (Print):October 1, 1976Publication History Published online1 May 2002Published inissue 1 October 1976https://pubs.acs.org/doi/10.1021/jo00884a012https://doi.org/10.1021/jo00884a012research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electronic Compensation Technique to Mitigate Nonlinear Phase Noise (2004)

Nonlinear phase noise, often called the Gordon-Mollenauer effect, can be compensated electronically by subtracting from the received phase a correction proportional to the received intensity. The optimal scaling factor is derived analytically and found to be approximately equal to half of the ratio of mean nonlinear phase noise and the mean received intensity. Using optimal compensation, the standard deviation of residual phase noise is halved, doubling the transmission distance in systems limited by nonlinear phase noise.
PlasMapper: a web server for drawing and auto-annotating plasmid maps (2004)

PlasMapper is a comprehensive web server that automatically generates and annotates high-quality circular plasmid maps. Taking only the plasmid/vector DNA sequence as input, PlasMapper uses sequence pattern matching and BLAST alignment to automatically identify and label common promoters, terminators, cloning sites, restriction sites, reporter genes, affinity tags, selectable marker genes, replication origins and open reading frames. PlasMapper then presents the identified features in textual form and as high-resolution, multicolored graphical output. The appearance and contents of the output can be customized in numerous ways using several supplied options. Further, PlasMapper images can be rendered in both rasterized (PNG and JPG) and vector graphics (SVG) formats to accommodate a variety of user needs or preferences. The images and textual output are of sufficient quality that they may be used directly in publications or presentations. The PlasMapper web server is freely accessible at http://wishart.biology.ualberta.ca/PlasMapper.
Malignant Disease of the Thyroid Gland: A Clinico-Pathological Analysis of 54 Cases of Thyroid Malignancy (1934)

The material presented in this paper represents a careful clinico-pathological study of the 54 cases of thyroid malignancy which have been reported by the pathological laboratory of the New York Hospital during the past thirteen years, supplementing a previous report (9). During this period a total of approximately 100,000 admissions to the hospital have been made. Of this number, slightly over 28,000 have had surgical specimens diagnosed pathologically. Among these 28,000 surgical specimens, some 1,600 have been thyroid glands; 855 of which have represented thyroid tumors, an incidence of a little more than 50 per cent. In this group of tumors 42 have been histologically and clinically malignant and are included in this report. The other 12 cases have come from outside sources, chiefly through the kindness of Dr. John Rogers, to whom we are indebted both for the material and for the clinical histories. One case, of particular interest as representing an intermediate phase between adenoma and subsequent pseudo-sarcomatous malignant degeneration, was sent us through Dr. John Scott of Louisville, Kentucky.

Analyzing these figures, we see that the incidence of thyroid malignancy in the New York Hospital series represents almost exactly 2.5 per cent of all thyroid specimens, and about 4.7 per cent of all thyroid tumors. These percentages are quite comparable to those of other observers. In 1929, one of us (LWS) reported another series of 67 cases of thyroid malignancy from the Lahey Clinic, in which the incidence was 1.68 per cent. In the Mayo Clinic, the figure runs about the same: 1.6 per cent of all thyroid specimens from 1910 to 1916. Graham in Cleveland reports a similar figure, as do Craver (4) and Haagensen (7) from the Memorial Hospital in New York.
Functional imaging in the study of recovery patterns in bilingual aphasia (2001)

There is no causal account of recovery patterns in bilingual aphasia. We propose that the causal mechanisms can be partially revealed by combining neuropsychological and neuroimaging methods. We briefly review the potentials and limitations associated with functional neuroimaging experiments on normal and neurologically impaired patients and then focus on the different levels of description required to reveal the causal basis of recovery patterns in bilingual aphasics. Finally, we suggest how functional imaging investigations might be meaningfully undertaken with bilingual aphasic patients. We illustrate our argument with respect to five different patterns of recovery and consider the theoretical and practical implications of such research.
Serum-derived exosomes from non-viremic animals previously exposed to the porcine respiratory and reproductive virus contain antigenic viral proteins (2016)

PRRSV is the etiological agent of one of the most important swine diseases with a significant economic burden worldwide and limitations in vaccinology. Exosomes are 30-100 nm vesicles of endocytic origin. Remarkably, immunizations with exosomes containing antigens from tumors or pathogens are capable of eliciting protective immune responses, albeit variably, in cancer and infectious diseases. Here we describe the isolation, molecular composition and immunogenicity of serum-derived exosomes from naïve animals, from PRRSV viremic animals and from animals previously PRRSV infected but already free of viruses (non viremic). Exosomes were isolated through size exclusion chromatography and characterized by different methodologies. Exosome-enriched fractions from naïve and natural infected animals contained classical tetraspanin exosomal markers (CD63 and CD81) and high concentrations of particles in the size-range of exosomes as detected by nanoparticle tracking analysis and cryo-TEM. NanoLC-MS/MS was used to identify viral antigens associated to exosomes. PRRSV-proteins were detected in serum samples from only viremic animals and from animals previously infected already free of viruses (non-viremic), but not in controls. Moreover, immune sera from pigs previously exposed to PRRSV specifically reacted against exosomes purified from non-viremic pig sera in a dose-dependent manner, a reactivity not detected when naïve sera was used in the assay. To facilitate future studies, a scaling-up process was implemented. To the best of our knowledge, this is the first molecular characterization of serum-derived exosomes from naïve pigs and pigs actively or previously infected with PRRSV. The presence of antigenic viral proteins in serum-derived exosomes free of virus, suggest their use as a novel vaccine approach against PRRSV.
Comparison between Auditory and Visual Simple Reaction Times (2010)

Objective: The purpose of this study was to find out whether the simple reaction time was faster for auditory or visual stimulus and the factors responsible for improving the performance of the athlete. Methodology: 14 subjects were as- signed randomly into groups consisting of 2 members. Both the members from each group performed both the visual and auditory tests. The tests were taken from the DirectRT software program from a laptop. The DirectRT software consists of Testlabvisual and Testlabsounds to test the reaction times to visual and auditory stimuli. The 2 members from each group completed both the visual and auditory reaction times, the data was taken and the mean reaction time was calculated excluding the first and last values. Results: The results show that the mean visual reaction time is around 331 milliseconds as compared to the mean auditory reaction time of around 284 milliseconds. Conclusion: This shows that the auditory reaction time is faster than the visual reaction time. And also males have faster reaction times when compared to females for both auditory as well as visual stimuli.
Reducing barriers for e-business in SME's through an open service oriented infrastructure (2006)

The Danish Ministry of Science, Technology and Innovation wishes to establish the necessary services needed in a national service oriented architecture. A key piece of technology in this vision is a hierarchy of addressing services based on registries.The ministry will register all public sector institutions with their UBL-based1 invoice services in a master registry. This guarantees a critical mass of public sector institutions and offers a good value proposition to the SME's. Not only can they send all invoices to the public sector electronically but they also have the ability to send electronic invoices to other private companies registered in the registry.The ministry believes that this solution will demonstrate the advantages of a service oriented architecture [1] and infrastructure based on registries and that this demonstration will generate the broad use of registries for other services.The proposed solution [2] consists of elements normally associated with a web service architecture. What differentiates this proposal is not the content but the approach to lowering barriers by limiting implementation choices and ensuring a critical mass of service providers.
A LÍNGUA DE COMUNICAÇÃO CIENTÍFICA: UM ESTUDO SOBRE AS PUBLICAÇÕES NA REVISTA EVENTOS PEDAGÓGICOS (2012)

Este artigo trata das experiencias vivencias pela professora que organiza a Revista Eventos Pedagogicos, revista do Departamento de Pedagogia do Campus Universitario de Sinop – UNEMAT. A revista e organizada a partir dos artigos produzidos pelo 7o semestre de Pedagogia sobre suas pesquisas realizadas para os Trabalhos de Conclusao de Curso e, tambem, pelosartigos da comunidade. Este texto trata do contexto academico que se cria no momento de organizar uma edicao da revista em que o aluno se coloca como autor de um artigo cientifico, como cientista divulgador de sua producao de conhecimento e como organizador de umapublicacao.
Effect of surface roughness on the secondary ion yield in ion sputtering (1998)

There is extensive experimental evidence that, at low temperatures, surface erosion by ion bombardment roughens the sputtered substrate, leading to a self-affine surface. These changes in the surface morphology also modify the secondary ion yield. Here, we calculate analytically the secondary ion yield in terms of parameters characterizing the sputtering process and the interface roughness.
1.2 µm highly strained GaInAs/GaAs quantumwell lasers for singlemode fibre datalink (1999)

The potential use of highly strained GaInAs/GaAs quantum well lasers in high capacity singlemode fibre datalinks is discussed. Heatsink-free CW operation of 1.2 µm GaInAs/GaAs ridge waveguide lasers is demonstrated, with a characteristic temperature T0 of 140 K. The lasing wavelength was > 1.25 µm, which is the longest wavelength reported so far for GaInAs/GaAs systems. A preliminary experiment using 12 µm lasers for singlemode fibre data transmission is also performed.
Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery (2018)

To date, IL-17A antibodies remain the only therapeutic approach to correct the abnormal activation of the IL-17A/IL-17R signaling complex. Why is it that despite the remarkable success of IL-17 antibodies, there is no small molecule antagonist of IL-17A in the clinic? Here we offer a unique approach to address this question. In order to understand the interaction of IL-17A with its receptor, we combined peptide discovery using phage display with HDX, crystallography, and functional assays to map and characterize hot regions that contribute to most of the energetics of the IL-17A/IL-17R interaction. These functional maps are proposed to serve as a guide to aid in the development of small molecules that bind to IL-17A and block its interaction with IL-17RA.
Localization of ligands for L-selectin in mouse peripheral lymph node high endothelial cells by colloidal gold conjugates (1994)

L-selectin, a Ca(2+)-dependent lectin-like receptor, mediates lymphocyte attachment to high endothelial venules (HEV) of peripheral lymph nodes (PLN) during the process of lymphocyte homing. Two endothelial-derived ligands for L-selectin, known as GlyCAM-1 (Sgp50) and CD34 (Sgp90), have been identified by affinity precipitation of lymph node extracts with a chimeric molecule that combines the extracellular domains of L-selectin with the human IgG1 Fc region (L-selectin-IgG) (J Cell Biol 110:2221, 1990). Here, using a histologic probe based on colloidal gold conjugated to L-selectin-IgG (LS-Ig), we performed morphologic mapping of the HEV ligands in PLN at both the light and electron microscopic levels. With a postembedding labeling method, intense LS-Ig-gold staining of PLN HEV was observed, while the HEV of Peyer's patches (PP) were negative. The specificity of LS-Ig-gold staining was established by pretreatment of sections with sialidase and coincubation of sections with EGTA, fucoidin, or L-selectin-IgG itself. In ultrastructural studies of high endothelial cells(HEC), gold particles were bound to the trans-Golgi network(TGN) and to peripheral vesicles in the cytoplasm. Gold labeling was also detected in a patchy distribution on the entire luminal vascular surface of HEC. Although the perivascular fibroreticular sheath of HEV was frequently labeled limited labeling was observed on the basolateral surfaces of the HEC. In most cases, the HEC membrane surrounding migrating lymphocytes was negative. These results show that L-selectin ligands pass through the Golgi apparatus during their biosynthesis, are stored in secretory granules, and are expressed on the vascular luminal surface of the HEC. A polyclonal antiserum to GlyCAM-1 intensely stained intracellular organelles in the biosynthetic pathway including cytoplasmic vesicles, but failed to stain the cell surface of HEC. Given its presence in serum as a soluble factor, GlyCAM-1 is likely to be a secretory product.
The Origin and Development of the <i>*es-</i> VS. <i>*wes-</i> Suppletion in the Germanic Copula (2002)

Preview this article: The Origin and Development of the *es- VS. *wes- Suppletion in the Germanic Copula: From a Non-Brugmannian Standpoint, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/nowele.40.01tan-1.gif
Nuclear Import of the Stem–Loop Binding Protein and Localization during the Cell Cycle (2005)

A key factor involved in the processing of histone pre-mRNAs in the nucleus and translation of mature histone mRNAs in the cytoplasm is the stem-loop binding protein (SLBP). In this work, we have investigated SLBP nuclear transport and subcellular localization during the cell cycle. SLBP is predominantly nuclear under steady-state conditions and localizes to the cytoplasm during S phase when histone mRNAs accumulate. Consistently, SLBP mutants that are defective in histone mRNA binding remain nuclear. As assayed in heterokaryons, export of SLBP from the nucleus is dependent on histone mRNA binding, demonstrating that SLBP on its own does not possess any nuclear export signals. We find that SLBP interacts with the import receptors Impalpha/Impbeta and Transportin-SR2. Moreover, complexes formed between SLBP and the two import receptors are disrupted by RanGTP. We have further shown that SLBP is imported by both receptors in vitro. Three sequences in SLBP required for Impalpha/Impbeta binding were identified. Simultaneous mutation of all three sequences was necessary to abolish SLBP nuclear localization in vivo. In contrast, we were unable to identify an in vivo role for Transportin-SR2 in SLBP nuclear localization. Thus, only the Impalpha/Impbeta pathway contributes to SLBP nuclear import in HeLa cells.
A New Kind of Hybrid Cache Coherence Protocol for Multiprocessor with D-Cache (2011)

This paper introduces a new kind of hybrid Cache coherence protocol-MECSIF, which applicants for multiprocessor environment, based on hybrid cache line write strategy. Through the introduction of a small dictionary-D-Cache in system architecture, protocol overcomes the shortcoming of snoopy coherence protocol that data request was undifferentiated broadcasted. Protocol extends data block state so that eliminates "ping-pang" phenomenon, uses hybrid cache line write strategy to reduce L1 cache miss ratio. Simulation results show that the MECSIF protocol extent improves the efficiency of processor data access comparing with MESI protocol.