gebhart/patrepeval huggingface dataset:
A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice (2011)

Mutations of SQSTM1 occur in about10% of patients with Paget's disease of bone (PDB), but it is unclear whether they play a causal role or regulate susceptibility to an environmental trigger. Here we show that mice with a proline to leucine mutation at codon 394 of mouse sqstm1 (P394L), equivalent to the P392L SQSTM1 mutation in humans, develop a bone disorder with remarkable similarity to PDB. The P394L mutant mice developed focal bone lesions with increasing age and by 12 months, 14/18 (77%) heterozygotes and 20/21 (95%) homozygotes had lesions, compared with 0/18 (0%) wild-type littermates (P< 0.001). Lesions predominantly affected the lower limbs in an asymmetric manner and were characterized by focal increases in bone turnover, with increased bone resorption and formation, disruption of the normal bone architecture and accumulation of woven bone. Osteoclasts within lesions were larger and more nucleated than normal and some contained nuclear inclusions similar to those observed in human PDB. Osteoclast precursors from P394L mutant mice had increased sensitivity to RANKL in vitro resulting in the generation of osteoclasts that were larger and more nucleated than those generated from wild-type littermates. There was increased expression of sqstm1, autophagy-related gene 5 (atg5) and light chain 3 gene (lc3) in osteoclast precursors and increased LC3-II protein levels in Bafilomycin-treated osteoclasts from P394L mutant mice compared with wild-type suggesting dysregulation of autophagy and enhanced autophagosome formation. These studies demonstrate that SQSTM1 mutations can cause a PDB-like skeletal disorder in the absence of an additional trigger and provide a new disease model for PDB.
Preparation of Giant-Grain Seed Layer for Poly-Silicon Thin-Film Solar Cells (1999)

A silicon thin-film with giant grains has been formed on a stacked substrate having a low melting point metallic layer and a low heat capacitance layer. Grains as large as 17 µm could be fabricated by application of a single shot of an excimer-laser light pulse with light intensity gradient to this structure. This technology seems attractive for the fabrication of giant-grain poly-Si thin-film solar cells.
Identification and Function of the <i>pdxY</i> Gene, Which Encodes a Novel Pyridoxal Kinase Involved in the Salvage Pathway of Pyridoxal 5′-Phosphate Biosynthesis in <i>Escherichia coli</i> K-12 (1998)

pdrK encodes a pyridoxine (PN)/pyridoxal (PL)/pyridoxamine (PM) kinase thought to function in the salvage pathway of pyridoxal 5'-phosphate (PLP) coenzyme biosynthesis. The observation that pdxK null mutants still contain PL kinase activity led to the hypothesis that Escherichia coli K-12 contains at least one other B6-vitamer kinase. Here we support this hypothesis by identifying the pdxY gene (formally, open reading frame f287b) at 36.92 min, which encodes a novel PL kinase. PdxY was first identified by its homology to PdxK in searches of the complete E. coli genome. Minimal clones of pdxY+ overexpressed PL kinase specific activity about 10-fold. We inserted an omega cassette into pdxY and crossed the resulting pdxY::omegaKan(r) mutation into the bacterial chromosome of a pdrB mutant, in which de novo PLP biosynthesis is blocked. We then determined the growth characteristics and PL and PN kinase specific activities in extracts of pdxK and pdxY single and double mutants. Significantly, the requirement of the pdxB pdxK pdxY triple mutant for PLP was not satisfied by PL and PN, and the triple mutant had negligible PL and PN kinase specific activities. Our combined results suggest that the PL kinase PdxY and the PN/PL/PM kinase PdxK are the only physiologically important B6 vitamer kinases in E. coli and that their function is confined to the PLP salvage pathway. Last, we show that pdxY is located downstream from pdxH (encoding PNP/PMP oxidase) and essential tyrS (encoding aminoacyl-tRNA(Tyr) synthetase) in a multifunctional operon. pdxY is completely cotranscribed with tyrS, but about 92% of tyrS transcripts terminate at a putative Rho-factor-dependent attenuator located in the tyrS-pdxY intercistronic region.
Memory allocation and mapping in high-level synthesis - an integrated approach (2003)

With the increasing design complexity and performance requirement, data arrays in behavioral specification are usually mapped to memories in behavioral synthesis. This paper describes a new algorithm that overcomes two limitations of the previous works on the problem of memory-allocation and array-mapping to memories. Specifically, its key features are a tight link to the scheduling effect, which was totally or partially ignored by the existing memory synthesis systems, and supporting nonuniform access speeds among the ports of memories, which greatly diversify the possible (practical) memory configurations. Experimental data on a set of benchmark filter designs are provided to show the effectiveness of the proposed exploration strategy in finding globally best memory configurations.
Structure and Mechanism of Formation of Human Lens Fluorophore LM-1 (1999)

Human lens crystallins become progressively yellow-brown pigmented with age. Both fluorescent and non-fluorescent protein adducts and cross-links are formed, many of which result from the advanced Maillard reaction. One of them, LM-1, is a blue fluorophore that was earlier tentatively identified as a cross-link involving lysine residues (1). A two-step chromatographic system was used to unequivocally identify and quantitatively prepare a synthetic fluorescent cross-link with lysine residues that had identical UV, fluorescent, and chromatographic properties with both acetylated and non-acetylated LM-1. Proton, (13)C NMR, and molecular mass of the synthetic compound were identical with vesperlysine A, a fluorescent cross-link discovered by Nakamura et al. (2). The fragmentation patterns of vesperlysine A and LM-1 were identical as determined by NMR/mass spectrometry. Lenticular levels of vesperlysine A increase curvilinearly with age and reach 20 pmol/mg at 90 years. Levels correlate with degree of lens crystallin pigmentation and fluorescence and are increased in diabetes, in contrast to N(epsilon)-(carboxymethyl)lysine and pentosidine. Ascorbate, D-pentoses, and D-threose, but neither D-glucose under oxidative conditions, DL-glyceraldehyde, methylglyoxal, glyoxal, nor glycolaldehyde, are precursors. However, addition of C-2 compounds greatly catalyzes vesperlysine A formation from ribose. Thus, vesperlysine A/LM-1 is a novel product of the advanced Maillard reaction in vivo and a specific marker of a diabetic process in the lens that is different from glyco- and lipoxidation.
GreenBag: Energy-Efficient Bandwidth Aggregation for Real-Time Streaming in Heterogeneous Mobile Wireless Networks (2013)

Modern mobile devices are equipped with multiple network interfaces, including 3G/LTE and WiFi. Bandwidth aggregation over LTE and WiFi links offers an attractive opportunity of supporting bandwidth-intensive services, such as high-quality video streaming, on mobile devices. However, achieving effective bandwidth aggregation in mobile environments raises several challenges related to deployment, link heterogeneity, network fluctuation, and energy consumption. We present GreenBag, an energy-efficient bandwidth aggregation middleware that supports real-time data-streaming services over asymmetric wireless links, requiring no modifications to the existing Internet infrastructure and servers. GreenBag employs several techniques, including medium load balancing, efficient segment management, and energy-aware mode control, to resolve such challenges. We implement a prototype of GreenBag on Android-based mobile devices which hosts, to the best knowledge of the authors, the first LTE-enabled bandwidth aggregation prototype for energy-efficient real-time video streaming. Our experiment results in both emulated and real-world environments show that GreenBag not only achieves good bandwidth aggregation to provide QoS in bandwidth-scarce environments but also efficiently saves energy on mobile devices. Moreover, energy-aware GreenBag can minimize video interruption while consuming 14-25% less energy than the non-energy-aware counterpart in real-world experiments.
Ethylene Hydrogenation over Platinum Nanoparticle Array Model Catalysts Fabricated by Electron Beam Lithography:  Determination of Active Metal Surface Area (2002)

Pt nanoparticle array model catalysts with 28 ± 2 nm diameters and 100 ± 2 nm interparticle spacing have been fabricated with electron beam lithography on alumina supports. A novel method for cleaning the Pt nanoparticle arrays, involving low dosages of NO2 and CO and mild temperature flashing, was established. This cleaning procedure was crucial for measuring reaction rates over the nanoparticle arrays. The reactivity of the Pt/Al2O3 arrays was compared to a Pt(111) single crystal for the ethylene hydrogenation reaction. The activation energy and the pressure dependence of the H2 and C2H4 on the nanoparticle array were in excellent agreement with the kinetic data on the Pt(111) single-crystal model catalyst. Because the ethylene hydrogenation reaction is structure insensitive, the rate equation for Pt(111) can be applied to the Pt nanoparticle arrays. The calculated turnover frequency led to a calculated active metal surface area that compared very well with an active metal surface area on the basis of geometry. This reaction can therefore be used to determine the active metal surface area of the Pt nanoparticle array model catalysts. The arrays were characterized with AFM, SEM, XPS, and AES before and after being exposed to reaction conditions.
Dynamic Fiber-Optic Shape Sensing Using Fiber Segment Interferometry (2017)

Dynamic fiber-optic shape sensing, often also referred to as curvature or bend sensing, is demonstrated using fiber segment interferometry, where chains of fiber segments, separated by broadband Bragg grating reflectors, are interrogated using range-resolved interferometry. In this paper, the theory of interferometric curvature sensing using fiber segments is developed in detail, including techniques to infer lateral displacements from the measured differential strain data and methods for directional calibration of the sensor. A proof-of-concept experiment is performed, where four fiber strings, each containing four fiber segments of gauge length 20 cm each, are attached to the opposing sides of a flexible support structure and the resulting differential strain measurements are used to determine the lateral displacements of a 0.8 m cantilever test object in two dimensions. Dynamic tip displacement measurements at 40 nm · Hz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-0.5</sup> noise levels over a 21 kHz bandwidth demonstrate the suitability of this approach for highly sensitive and cost-effective fiber-optic lateral displacement or vibration measurements.
The chatbot feels you - a counseling service using emotional response generation (2017)

Early study tries to use chatbot for counseling services. They changed drinking habit of who being consulted by leading them via intervene chatbot. However, the application did not concerned about psychiatric status through continuous conversation with user monitoring. Furthermore, they had no ethical judgment method that about the intervention of the chatbot. We argue that more reasonable and continuous emotion recognition will make better mental healthcare experiment. It will be more proper clinical psychiatric consolation in ethical view as well. This paper suggests a introduce a novel chatbot system for psychiatric counseling service. Our system understands content of conversation based on recent natural language processing (NLP) methods with emotion recognition. It senses emotional flow through the continuous observation of conversation. Also, we generate personalized counseling response from user input, to do this, we use additional constrains to generation model for the proper response generation which can detect conversational context, user emotion and expected reaction.
Scope, Kinetics, and Mechanistic Aspects of Aerobic Oxidations Catalyzed by Ruthenium Supported on Alumina (2003)

The Ru/Al(2)O(3) catalyst was prepared by modification of the preparation of Ru(OH)(3).n H(2)O. The present Ru/Al(2)O(3) catalyst has high catalytic activities for the oxidations of activated, nonactivated, and heterocyclic alcohols, diols, and amines at 1 atm of molecular oxygen. Furthermore, the catalyst could be reused seven times without a loss of catalytic activity and selectivity for the oxidation of benzyl alcohol. A catalytic reaction mechanism involving a ruthenium alcoholate species and beta-hydride elimination from the alcoholate has been proposed. The reaction rate has a first-order dependence on the amount of catalyst, a fractional order on the concentration of benzyl alcohol, and a zero order on the pressure of molecular oxygen. These results and kinetic isotope effects indicate that beta-elimination from the ruthenium alcoholate species is a rate-determining step.
The influence of topology selection on the design of EV/HEV propulsion systems (2003)

The adoption of the 42 V Powernet standard has focused substantial research effort into the design of electric machines for hybrid vehicles. This letter investigates the potential performance benefits afforded by adopting a cascaded inverter topology on the overall system and motor performance. As a particular design example, this letter shows that a cascaded inverter driving an open winding motor can increase the high-speed power density of an induction motor by 73%. For an interior permanent magnet motor, the cascaded topology can increase low-speed torque by 9% and high-speed power by up to 300%. In all cases, the power increase is achieved without increasing the phase current over a more traditional system.
A four-point electrical measurement technique for characterizing mask superposition errors on semiconductor wafers (1978)

Data are obtained using a microelectronic van der Pauw resistor structure in conjunction with automated test, computing, and graphic display equipment. Computer-drawn vector displacement maps, equivalue contour maps, and histograms are used to display the data in a format which assists in the interpretation of sources of MSE. A six-parameter model which takes into account mask translation, rotation, and expansion is shown to fit successfully the data obtained from test wafers masked using conventional alignment equipment. A comparative evaluation of the performance of a group of aligners used for manufacturing integrated circuits is given, and an investigation of the consequences of masking silicon wafers which have been subjected to high-temperature processing is performed.
Successful bystander-administered intranasal naloxone reversal of opioid overdose between two veterans: A case report (2017)

Opioid overdose-related morbidity and mortality remain one of the most pressing public health crises. Overdose education and naloxone distribution have emerged as an effective initiative for mitigating overdose deaths. This case highlights areas of patient education essential to optimizing treatment outcome when using a naloxone reversal kit. The patient is a 46-year-old white male with a past medical history significant for opioid use disorder, alcohol use disorder, stimulant use disorder, sedative-hypnotic use disorder, and posttraumatic stress disorder. The patient received an intranasal naloxone kit during residential substance abuse treatment. Five months later, the patient requested a new kit and was asked about the disposition of his previous kit. The patient recounted how he was telephoned to pick up an unconscious friend (and fellow veteran) from a nonresidential location. Upon arrival, the patient recognized opioid products near his friend and took steps to reverse the suspected opioid overdose with his 2 mg/2 mL naloxone intranasal kit. The reversal was successful, but many critical rescue response steps were omitted. This case report may guide future changes to educating patients on appropriate responses to opioid overdoses with naloxone. A PubMed search located one other case report of successful naloxone reversal of opioid overdose in the veteran population, which involved fentanyl sold as heroin. In our case report, a veteran successfully used his naloxone kit to reverse a suspected opioid overdose in another veteran, but he incompletely provided the rescue response. This experience may influence content changes for future overdose education and naloxone distribution training.
Monte Carlo investigation of imprisonment of resonance radiation with partial frequency redistribution (1988)

A Monte Carlo simulation based on the physical processes described by a partial redistribution function has been developed. Results are in good agreement with analytical calculations. The simulation has been tested for the rare gases Ar, Kr and Xe in the pressure range between 0.01 and 10 Torr.
Learning Novelty-Aware Ranking of Answers to Complex Questions (2019)

Result ranking diversification has become an important issue for web search, summarization, and question answering. For more complex questions with multiple aspects, such as those in community-based question answering (CQA) sites, a retrieval system should provide a diversified set of relevant results, addressing the different aspects of the query, while minimizing redundancy or repetition. We present a new method, DRN , which learns novelty-related features from unlabeled data with minimal social signals, to emphasize diversity in ranking. Specifically, DRN parameterizes question-answer interactions via an LSTM representation, coupled with an extension of neural tensor network, which in turn is combined with a novelty-driven sampling approach to automatically generate training data. DRN provides a novel and general approach to complex question answering diversification and suggests promising directions for search improvements.
ADVANCED GLYCATION END-PRODUCTS IN PATIENTS WITH CHRONIC ALCOHOL MISUSE (2004)

Our findings suggest a more complex relationship among advanced glycation, oxidative stress and metabolism of ethanol and their link to nutrition and nutrition-associated parameters. AGE as a result of oxidative stress might be similarly linked to increased cardiovascular risk of heavy alcohol drinkers, as are malnutrition and inflammation; however, further studies are needed to confirm this hypothesis.
Spiral imaging artifact reduction: A comparison of two k‐trajectory measurement methods (2009)

We introduce MFM as an effective and accurate correction technique for spiral imaging, where a comparison of MFM and DCT has shown that both techniques are accurate correction techniques for spiral imaging.
A case study of CES: a distributed collaborative editing system implemented in Argus (1992)

Experience implementing CES, a distributed collaborative editing system, is described. CES was written in Argus, a language that was designed to support the construction of reliable distributed programs, and exhibits a number of requirements typical of distributed applications. The authors' experience illustrates numerous areas in which the support provided by Argus for meeting those requirements was quite helpful, but also identifies several areas in which the support provided by Argus was inadequate. Some of the problems arise because of the distinction in Argus (and in other systems) between locally and remotely accessible data and the mechanisms provided for implementing each. Others arise because of limitations of the mechanisms for building user-defined data types. The authors discuss the problems they encountered, including the implications for other systems. They also suggest solutions to the problems, or in some cases further research directed at finding solutions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Characteristics of the Ionic Wind Generation with Corona Electrodes Installed in Form of the Ring (2014)

The electric power can be converted into the mechanical power by a corona discharge system. This way has not stronger force than a electric motor. But it has been applied in various industrial fields because of many advantages, no moving parts, smaller noise, simpler structure, minimizing et al. In this paper, corona discharge system with multiple corona electrode installed in form of the ring, has been studied by focusing on the electrical and mechanical characteristics. Intensity of the corona discharge depends on applied electric field, and electric field is related to the applied voltage, discharge gap spacing(s), distance between each corona electrodes(d). As a result, in the case d/s=0.9, most intensive discharge occurred in this experiments. In the region of d/s<0.9, ionic wind velocity has saturation value in spite of decreasing corona current, because each ion velocities increase by the increasing electric field.
The flood‐hydrograph and valley‐storage (1943)

In a paper presented last year by Professor BARROWS [see 1 of “References” at end of paper] the flood inflow‐hydrograph was developed from the flood‐hydrograph by the use of a storage‐relation determined from the recession‐curve. The chief criticism made in the discussion of this paper was of the basic assumption that the storage figured from, the recession‐curve is applicable to the rising stage. The writer does not take exception to this, as will be described later. He has found, however, that the flood‐hydrograph does not lend itself in this way to a determinate‐result for the inflow.
Volume fraction measurements of water in oil by an ultrasonic technique (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleVolume fraction measurements of water in oil by an ultrasonic techniqueCostas Tsouris and Lawrence L. TavlaridesCite this: Ind. Eng. Chem. Res. 1993, 32, 5, 998–1002Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ie00017a035https://doi.org/10.1021/ie00017a035research-articleACS PublicationsRequest reuse permissionsArticle Views305Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts