gebhart/patrepeval huggingface dataset:
TATA-Binding Protein-Like Protein (TLP/TRF2/TLF) Negatively Regulates Cell Cycle Progression and Is Required for the Stress-Mediated G<sub>2</sub> Checkpoint (2003)

The TATA-binding protein (TBP) is a universal transcription factor required for all of the eukaryotic RNA polymerases. In addition to TBP, metazoans commonly express a distantly TBP-related protein referred to as TBP-like protein (TLP/TRF2/TLF). Although the function of TLP in transcriptional regulation is not clear, it is known that TLP is required for embryogenesis and spermiogenesis. In the present study, we investigated the cellular functions of TLP by using TLP knockout chicken DT40 cells. TLP was found to be dispensable for cell growth. Unexpectedly, TLP-null cells exhibited a 20% elevated cell cycle progression rate that was attributed to shortening of the G(2) phase. This indicates that TLP functions as a negative regulator of cell growth. Moreover, we found that TLP mainly existed in the cytoplasm and was translocated to the nucleus restrictedly at the G(2) phase. Ectopic expression of nuclear localization signal-carrying TLP resulted in an increase (1.5-fold) in the proportion of cells remaining in the G(2)/M phase and apoptotic state. Notably, TLP-null cells showed an insufficient G(2) checkpoint when the cells were exposed to stresses such as UV light and methyl methanesulfonate, and the population of apoptotic cells after stresses decreased to 40%. These phenomena in G(2) checkpoint regulation are suggested to be p53 independent because p53 does not function in DT40 cells. Moreover, TLP was transiently translocated to the nucleus shortly (15 min) after stress treatment. The expression of several stress response and cell cycle regulatory genes drifted in a both TLP- and stress-dependent manner. Nucleus-translocating TLP is therefore thought to work by checking cell integrity through its transcription regulatory ability. TLP is considered to be a signal-transducing transcription factor in cell cycle regulation and stress response.
In praise of thiosulfate (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn praise of thiosulfateR. J. Tykodi Cite this: J. Chem. Educ. 1990, 67, 2, 146Publication Date (Print):February 1, 1990Publication History Received3 August 2009Published online1 February 1990Published inissue 1 February 1990https://doi.org/10.1021/ed067p146RIGHTS & PERMISSIONSArticle Views409Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alertsclose Get e-Alerts
Computer graphics instruction in VizClass (2005)

VizClass is a university classroom environment designed to offer students in computer graphics and engineering courses up-to-date visualization technologies. Three digital whiteboards and a three-dimensional stereoscopic display provide complementary display surfaces. Input devices include touchscreens on the digital whiteboards, remote keyboards, data gloves, and hand-position sensors.We use observations, interviews, and surveys to examine the pedagogical impacts of VizClass for teaching and learning computer graphics and virtual reality. Preliminary findings include positive student and teacher attitudes and greater learner engagement in after-class collaborations.
Efficacy of radiotherapy in patients on progression after treatment with ipilimumab 3 mg/kg (2014)

Background Ipilimumab, a fully human monoclonal antibody (IgG1) that promote antitumor immunity by blocking CTLA4, was the first agent which showed a long-term survival benefit, about the 20% of patients, for the treatment of metastatic melanoma. The combination of ipilimumab with other therapies might improve its efficacy. The term “abscopal effect” refers to a regression of metastatic lesions distant from the primary site of radiotherapy (RT). This new phenomenon represent the systemic response observed in patients who received ipilimumab. Here we reported the outcomes from patients treated in the ipilimumab Italian expanded access program (EAP) who received RT after ipilimumab progression. Patients and methods Patients with advanced melanoma after ipilimumab progression were selected for analysis. Patients, who failed ipilimumab therapy and for whom no other therapeutic options were available, were elegible for radiotherapy. Results
Characterization of molecular beam epitaxially grown HgCdTe on CdTe and InSb buffer layers (1986)

Molecular beam epitaxially (MBE) grown layers of (001)CdTe and (001)HgCdTe were examined by RHEED, DCRC, XTEM, and EDS to assess the effect of growth parameters on crystal perfection. The CdTe layers were further investigated via low temperature photoluminescence (PL) and SIMS analysis to determine potential impurity incorporation from InSb substrates. In both sets of analysis substrate temperatures and substrate preparation were the parameters which most influenced film growth. Double crystal x-ray rocking curve (DCRC) data showed weak substrate dependence in lattice matched (001)CdTe. PL data showed a stronger influence of substrate temperature on radiative defect incorporation. The HgCdTe alloy also showed structural dependence on substrate temperature in XTEM micrographs of precipitate formation which were confirmed by in situ EDS. Lateral compositional uniformity of alloy layers was determined by step-and-repeat infrared transmission measurements across a 3 in. GaAs wafer. The data have indicated an average 300 K cutoff wavelength of 7.05±0.5 μm across a full diameter.
This Television Monster (1955)

By providing evidence of the positive results of television in the United States, an argument is presented that the misgivings in Australia over the introduction of television are erroneous. It is suggested that the introduction of the 'Television Monster' in Australia would yield positive results by stimulating economic activity, developing the electronics industry and increasing competitiveness among telecasters to provide quality programming.
Tungsten Through-Silicon Via Technology for Three-Dimensional LSIs (2008)

Tungsten through-silicon via (W-TSV) technology is investigated for the fabrication of three-dimensional (3D) LSI chips having low-resistive TSVs with a width less than 3 µm. In our 3D integration technology, completed two-dimensional (2D) LSI chips including metal–oxide–semiconductor field-effect transistors (MOSFETs) and metal wirings are vertically stacked through a number of short vertical interconnections called TSV with lengths ranging from several microns to several tens of microns. The W-TSV technology is mainly divided into three low-temperature processes: deep-trench etching, dielectric layer formation, and filling with a conductive material. We successfully formed deep Si trenches through a 6-µm-thick SiO2 dielectric layer by the modified Bosch process. The depth of the resulting Si trenches with a dielectric layer is approximately 40 µm. A SiO2 layer was formed at the bottom and on the sidewall of the Si trenches by sub-atmospheric chemical vapor deposition (SACVD) method using tetraethylorthosilicate (TEOS) and O3. In addition, we succeeded in uniformly depositing a conformal W metal layer by time-modulated W-CVD method at 300 °C.
Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function (2011)

Glucocorticoids and mineralocorticoids are steroid hormones classically thought to be secreted exclusively by the adrenal glands. However, recent evidence has shown that corticosteroids can also be locally synthesized in various other tissues, including primary lymphoid organs, intestine, skin, brain, and possibly heart. Evidence for local synthesis includes detection of steroidogenic enzymes and high local corticosteroid levels, even after adrenalectomy. Local synthesis creates high corticosteroid concentrations in extra-adrenal organs, sometimes much higher than circulating concentrations. Interestingly, local corticosteroid synthesis can be regulated via locally expressed mediators of the hypothalamic-pituitary-adrenal (HPA) axis or renin-angiotensin system (RAS). In some tissues (e.g., skin), these local control pathways might form miniature analogs of the pathways that regulate adrenal corticosteroid production. Locally synthesized glucocorticoids regulate activation of immune cells, while locally synthesized mineralocorticoids regulate blood volume and pressure. The physiological importance of extra-adrenal glucocorticoids and mineralocorticoids has been shown, because inhibition of local synthesis has major effects even in adrenal-intact subjects. In sum, while adrenal secretion of glucocorticoids and mineralocorticoids into the blood coordinates multiple organ systems, local synthesis of corticosteroids results in high spatial specificity of steroid action. Taken together, studies of these five major organ systems challenge the conventional understanding of corticosteroid biosynthesis and function.
Cytoskeletal Integrity as a Drug Target (2005)

The cytoskeleton provides structural integrity and determines localization of proteins and organelles throughout the cell. The focus on structure and transport has overshadowed the role this ubiquitous network plays in cell signaling cascades, though it participates in transduction of signals from the plasma membrane to the nucleus. Clearly the discovery that neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brain are made up of the microtubule (MT)-associated protein tau and evidence that the toxic amyloid peptides in AD can lead to tau hyper-phosphorylation and cytoskeletal dystrophy support the assertion that disruption of the MT network is an early signaling event in neurodegenerative cascades. Thus we have been testing the hypothesis that drugs that can moderate such signals through interactions with MTs would protect neurons against Abeta toxicity. Drugs targeted to MTs are currently used as anti-cancer agents, due to their blockade of cell proliferation and induction of cell death. However, we and others have now found that low concentrations of compounds that help stabilize MTs do indeed protect post-mitotic neurons challenged with various toxic stimuli. Therefore we propose that the cytoskeletal network actually serves as a sensor for the overall state of the neurons and a first-line transducer of stress signals. Drugs that can moderate initiation of such early signaling events do protect against disruption of the cytoskeleton and neuritic dystrophy in neuronal cell cultures. In vivo proof-of-concept studies in animal models will require the development of agents that can protect cytoskeletal integrity and also cross the blood brain barrier.
Analysis of SAT Type Foot-And-Mouth Disease Virus Capsid Proteins and the Identification of Putative Amino Acid Residues Affecting Virus Stability (2013)

Foot-and-mouth disease virus (FMDV) initiates infection by adhering to integrin receptors on target cells, followed by cell entry and disassembly of the virion through acidification within endosomes. Mild heating of the virions also leads to irreversible dissociation into pentamers, a characteristic linked to reduced vaccine efficacy. In this study, the structural stability of intra- and inter-serotype chimeric SAT2 and SAT3 virus particles to various conditions including low pH, mild temperatures or high ionic strength, was compared. Our results demonstrated that while both the SAT2 and SAT3 infectious capsids displayed different sensitivities in a series of low pH buffers, their stability profiles were comparable at high temperatures or high ionic strength conditions. Recombinant vSAT2 and intra-serotype chimeric viruses were used to map the amino acid differences in the capsid proteins of viruses with disparate low pH stabilities. Four His residues at the inter-pentamer interface were identified that change protonation states at pH 6.0. Of these, the H145 of VP3 appears to be involved in interactions with A141 in VP3 and K63 in VP2, and may be involved in orientating H142 of VP3 for interaction at the inter-pentamer interfaces.
Observation of Propagating Brush Discharge on Insulating Film With Grounded Antistatic Materials (2004)

A propagating brush discharge (PBD) usually occurs on a highly charged thin film with a grounded metal backing plate and often becomes energetic enough to ignite a flammable gas/vapor and even a dust cloud. In an actual situation, a PBD is seen on the surface of a large-sized flexible intermediate bulk container (FIBC) during its filling and/or emptying processes in an industrial site when the fabric of the FIBC is highly insulating. Anticipating that a PBD could occur even on an antistatic FIBC if it were used with an insulating inner bag, various types of antistatic fabrics for FIBCs in contact with an insulating polyethylene terephthalate (PET) sheet were put to the test. An antistatic fabric was grounded, and the PET sheet on the fabric was charged with a corona charger. A PBD was then generated by approaching a grounded spherical electrode. The discharge patterns were observed, and the currents and charge amounts were measured. A thin metallic fiber woven on an insulating fabric was found to drastically enhance the transferring of charge during a PBD, probably because of the corona discharges emanating from the metallic fiber. The resistivity of the fabric also affected the charge transference. The incendiary nature of each mode of PBD was discussed.
<title>Practical air-assisted ionographic printing</title> (1990)

The Corjet1 is an air-assisted ionographic printing device that offers advantages in the design of xerographic printers over the conventional laser scanned systems. The practical implementation of this technology required the solution of certain unique problems during its evolutionalry development.
Report on the 5 <sup>th</sup> IFIP international workshop on quality of service (IWQOS'97) (1997)

This paper presents a summary of the fifth International Workshop on Quality of Service (IWQOS) which was held at Columbia University in May 1997. The goal of this three-day meeting was to foster interaction between researchers active in the area of Quality of Service(QOS) research, to reflect on past experiences and lessons learnt, and to discuss future QOS challenges. To reflect this goal, this year's workshop included a hot program made up of (i) a keynote address on "Programming Telecommunications Networks"; (ii) panels addressing "QOS for Distributed Object Computing Middleware --- Fact or Fiction?" and "Reservations about Reservations"; (iii) a workshop invited paper entitled, "Quality of Service --- Where are we?" and (iv) ten technical sessions that included new topics for IWQOS such as mobile communications, QOS routing and QOS-based transport systems. This report summarizes the technical program and captures the main themes and major areas of discussion that emerged during IWQOS'97.
Titration of Reagents (2003)

This chapter examines in more detail the necessary practical skills needed to facilitate the development and sustainability of ELISAs. Basic methodologies to set up all systems are discussed so that the reader can both investigate the possibilities of tests using his or her reagents and use with confidence reagents obtained from other sources. As with all other tests, it is vital that scientists realize the principles of the methods to allow good judgement based on quantifiable and controllable features. In other words, there should be a full understanding of what is being performed in the laboratory. The intention of this training is to produce new skills and understanding as well as to encourage critical assessment. Such a mentality is necessary and supported through the application of statistical criteria to results and to continuous monitoring of performance.
A class of population genetic questions formulated as the generalized occupancy problem. (1993)

In categorical genetic data analysis when the sampling units are classified into an arbitrary number of distinct classes, sometimes the sample size may not be large enough to apply large sample approximations for hypothesis testing purposes. Exact sampling distributions of several statistics are derived here, using combinatorial approaches parallel to the classical occupancy problem to help overcome this difficulty. Since the multinomial probabilities can be unequal, this situation is described as a generalized occupancy problem. The sampling properties derived are used to examine nonrandomness of occurrence of mutagen-induced mutations across loci, to devise tests of Hardy-Weinberg proportions of genotype frequencies in the presence of a large number of alleles, and to provide a global test of gametic phase disequilibrium of several restriction site polymorphisms.
Spray Freeze Drying in a Fluidized Bed at Normal and Low Pressure (2006)

The aim of this study is to develop the spray freeze drying process and its hardware and to investigate its capabilities to dry thermosensible substances such as pharma-proteins at normal and low pressures. As the result, the spray freeze fluidized–bed dryer was constructed. During the study, the drying kinetic comparison between classical and spray freeze–drying technologies was done. Spray freeze drying has shown short process times and allows advanced control, product particle shape and size uniformity, and high solubility. This shows that the fluidized-bed freeze-drying process could be an alternative for classical freeze-drying processes. Identified problems are the low yield of the primary drying phase and the strong electrostatic effects during the secondary drying step. However, the innovative process has shown an excellent capability to dry and stabilize the thermosensitive substances, such as pharma-proteins.
HYPSOMETRIC (AREA-ALTITUDE) ANALYSIS OF EROSIONAL TOPOGRAPHY (1952)

Research Article| November 01, 1952 HYPSOMETRIC (AREA-ALTITUDE) ANALYSIS OF EROSIONAL TOPOGRAPHY ARTHUR N STRAHLER ARTHUR N STRAHLER DEPARTMENT OF GEOLOGY, COLUMBIA UNIVERSITY, NEW YORK 27, N. Y. Search for other works by this author on: GSW Google Scholar GSA Bulletin (1952) 63 (11): 1117–1142. https://doi.org/10.1130/0016-7606(1952)63[1117:HAAOET]2.0.CO;2 Article history received: 12 Dec 1951 first online: 02 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Search Site Citation ARTHUR N STRAHLER; HYPSOMETRIC (AREA-ALTITUDE) ANALYSIS OF EROSIONAL TOPOGRAPHY. GSA Bulletin 1952;; 63 (11): 1117–1142. doi: https://doi.org/10.1130/0016-7606(1952)63[1117:HAAOET]2.0.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGSA Bulletin Search Advanced Search Abstract The percentage hypsometric curve (area-altitude curve) relates horizontal cross-sectional area of a drainage basin to relative elevation above basin mouth. By use of dimensionless parameters, curves can be described and compared irrespective of true scale. Curves show distinctive differences both in sinuosity of form and in proportionate area below the curve, here termed the hypsometric integral. A simple three-variable function provides a satisfactory series of model curves to which most natural hypsometric curves can be fitted. The hypsometric curve can be equated to a mean ground-slope curve if length of contour belt is taken into account.Stages of youth, maturity, and old age in regions of homogeneous rock give a distinctive series of hypsometric forms, but mature and old stages give identical curves unless monadnock masses are present. It is therefore proposed that this terminology be replaced by one consisting of an inequilibrium stage, an equilibrium stage, and a monadnock phase.Detailed morphometric analysis of basins in five sample areas in the equilibrium stage show distinctive, though small, differences in hypsometric integrals and curve forms. In general, drainage basin height, slope steepness, stream channel gradient, and drainage density show a good negative correlation with mean integrals. Lithologic and structural differences between areas or recent minor uplifts may account for certain curve differences. Regions of strong horizontal structural benching give a modified series of hypsometric curves.Practical applications of hypsometric analysis are foreseen in hydrology, soil erosion and sedimentation studies, and military science. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Software Pipelining for Coarse-Grained Reconfigurable Instruction Set Processors (2002)

This paper shows that software pipelining can be an effective technique for code generation for coarse-grained reconfigurable instruction set processors. The paper describes a technique, based on adding an operation assignment phase to software pipelining, that performs reconfigurable instruction generation and instruction scheduling on a combined algorithm. Although typical compilers for reconfigurable processors perform these steps separately, results show that the combination enables a successful usage of the reconfigurable resources. The assignment algorithm is the key for using software pipelining on the reconfigurable processor. The technique presented is also able to exploit spatial computation inside the reconfigurable functional unit by which the output of a processing element is directly connected to the input of another processing element without the need of an intermediate register. Results show that it is possible to reduce the cycle count by using this spatial computation.
Learning Spatiotemporal Features for Infrared Action Recognition with 3D Convolutional Neural Networks (2017)

Infrared (IR) imaging has the potential to enable more robust action recognition systems compared to visible spectrum cameras due to lower sensitivity to lighting conditions and appearance variability. While the action recognition task on videos collected from visible spectrum imaging has received much attention, action recognition in infrared (IR) videos is significantly less explored. Our objective is to exploit imaging data in this modality for the action recognition task. In this work, we propose a novel two-stream 3D convolutional neural network architecture by introducing the discriminative code layer and the corresponding discriminative code loss function. The proposed network processes IR images and the IR-based optical flow field sequences. We pretrain the 3D CNN model on the visible spectrum Sports-1M action dataset and finetune it on the Infrared Action Recognition (InfAR) dataset. We conduct an elaborate analysis of different fusion schemes (weighted average, single and double-layer neural nets) applied to different 3D CNN outputs. Experimental results demonstrate that our approach can achieve state-of-the-art average precision performances on the InfAR dataset.