gebhart/patrepeval huggingface dataset:
Optimizing dendritic cell‐based immunotherapy in multiple myeloma: intranodal injections of idiotype‐pulsed CD40 ligand‐matured vaccines led to induction of type‐1 and cytotoxic T‐cell immune responses in patients (2010)

Vaccination with idiotype (Id) protein-pulsed dendritic cells (DCs) has been explored in multiple myeloma and the results have been disappointing. To improve the efficacy of DC vaccination in myeloma, we investigated the use of Id- and keyhole limpet haemocyanin (KLH)-pulsed, CD40 ligand-matured DCs administered intranodally. Nine patients with smouldering or stable myeloma without treatment were enrolled and DC vaccines were administered at weekly intervals for a total of four doses. Following vaccination, all patients mounted Id-specific gamma-interferon T-cell response. Interleukin-4 response was elicited in two, and skin delayed-type hypersensitivity reaction occurred in seven patients. More importantly, Id-specific cytotoxic T-cell responses were also detected in five patients. Most if not all patients mounted a positive T-cell response to KLH following vaccination. At 1-year follow-up, six of the nine patients had stable disease, while three patients had slowly progressive disease even during the vaccination period. At 5-year follow-up, four of the six patients continued with stable disease. No major side effects were noted. In summary, intranodal administration of Id-pulsed CD40 ligand-matured DCs was able to induce Id-specific T and B-cell responses in patients. Current efforts are geared towards breaking tumour-mediated immune suppression and improving clinical efficacy of this immunotherapy.
Dynamic interactions of the asialoglycoprotein receptor subunits with coated pits. Enhanced interactions of H2 following association with H1. (1994)

Lateral mobility studies comparing native and mutated membrane proteins, combined with treatments that alter clathrin lattice structure, can measure membrane protein-coated pit interactions in intact cells (Fire, E., Zwart, D., Roth, M. G., and Henis, Y. I. (1991) J. Cell Biol. 115, 1585-1594). We applied this approach to study the interactions of the H1 and H2 human asialoglycoprotein receptor subunits with coated pits. The lateral mobilities of singly expressed and coexpressed H1 and H2B (the H2 species that reaches the cell surface) were measured by fluorescence photobleaching recovery. They were compared with mutant proteins, H1(5A) (Tyr-5 replaced by Ala) and H2(5A) (Phe-5 replaced by Ala). While the mobile fractions of H1, H2B, and their mutants were similar, the lateral diffusion rate (measured by D, the lateral diffusion coefficient) was significantly slower for H1, whether expressed alone or with H2B. Coexpression with H1 reduced D of H2B to that of H1. Disruption of the clathrin lattices by hypertonic medium elevated D of H1, H1(5A), H2B, and H2(5A) to the same final level, without affecting their mobile fractions. Cytosol acidification, which retains altered clathrin lattices attached to the membrane and prevents coated vesicle formation, immobilized part of the H1 molecules, reflecting stable entrapment in "frozen" coated pits. H1(5A), H2B, and H2(5A) were not affected; however, coexpression of H2B with H1 conferred the sensitivity to cytosol acidification on H2B. Our results suggest that H1 lateral mobility is inhibited by dynamic interactions with coated pits in which Tyr-5 is involved. H2B resembles H1(5A) rather than H1, and its interactions with coated pits are weaker; efficient interaction of H2B with coated pits depends on complex formation with H1.
DYNAMIC ROUTING POLICIES FOR MULTISKILL CALL CENTERS (2008)

We consider the problem of routing calls dynamically in a multiskill call center. Calls from different skill classes are offered to the call center according to a Poisson process. The agents in the center are grouped according to their heterogeneous skill sets that determine the classes of calls they can serve. Each agent group serves calls with independent exponentially distributed service times. We consider two scenarios. The first scenario deals with a call center with no buffers in the system, so that every arriving call either has to be routed immediately or has to be blocked and is lost. The objective in the system is to minimize the average number of blocked calls. The second scenario deals with call centers consisting of only agents that have one skill and fully cross-trained agents, where calls are pooled in common queues. The objective in this system is to minimize the average number of calls in the system. We obtain nearly optimal dynamic routing policies that are scalable with the problem instance and can be computed online. The algorithm is based on one-step policy improvement using the relative value functions of simpler queuing systems. Numerical experiments demonstrate the good performance of the routing policies. Finally, we discuss how the algorithm can be used to handle more general cases with the techniques described in this article.
Numerical Investigation of Transmission Lines and Components in Damascene Technology (2002)

The development of multilayered, highly integrated circuit boards using damascene technology and copper as a conductor material is a promising way to achieve small and compact modules with high functionality. As copper as conductor can carry much higher current densities as aluminium, the size of transmission lines can be reduced down to a minimum value of 2.5 μm in width and 0.4 μm height. Different types of lines can be developed in this technology. Due to the small dimensions comparable to the skin depth of the realized structures conductor loss has to be taken into account. Therefore accurate simulation tools, capable of considering also the field inside the conductors, are necessary. Common tools for planar circuit design are not applicable. In this contribution the numerical investigation and comparative study of different transmission lines, done by a mode matching approach and the method of lines, will be presented. Line types with dimensions most suitable to be realized in this technology, are shown.
Fragile H.R. 10 coalition may fall apart (1999)

Abstract When Congress reconvenes, the fragile coalition that supported the bill may fall apart.
A diagnostic genetic test for the physical mapping of germline rearrangements in the susceptibility breast cancer genes BRCA1 and BRCA2 (2012)

The BRCA1 and BRCA2 genes are involved in breast and ovarian cancer susceptibility. About 2 to 4% of breast cancer patients with positive family history, negative for point mutations, can be expected to carry large rearrangements in one of these two genes. We developed a novel diagnostic genetic test for the physical mapping of large rearrangements, based on molecular combing (MC), a FISH-based technique for direct visualization of single DNA molecules at high resolution. We designed specific Genomic Morse Codes (GMCs), covering the exons, the noncoding regions, and large genomic portions flanking both genes. We validated our approach by testing 10 index cases with positive family history of breast cancer and 50 negative controls. Large rearrangements, corresponding to deletions and duplications with sizes ranging from 3 to 40 kb, were detected and characterized on both genes, including four novel mutations. The nature of all the identified mutations was confirmed by high-resolution array comparative genomic hybridization (aCGH) and breakpoints characterized by sequencing. The developed GMCs allowed to localize several tandem repeat duplications on both genes. We propose the developed genetic test as a valuable tool to screen large rearrangements in BRCA1 and BRCA2 to be combined in clinical settings with an assay capable of detecting small mutations.
A Phase I Study of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib (LEE011) in Patients with Advanced Solid Tumors and Lymphomas (2016)

Ribociclib demonstrated an acceptable safety profile, dose-dependent plasma exposure, and preliminary signs of clinical activity. Phase I-III studies of ribociclib are under way in various indications. Clin Cancer Res; 22(23); 5696-705. ©2016 AACR.
Stress generation by electromigration (1976)

Stresses in aluminum thin films on TiN were studied in situ by transmission x-ray topography. Stress gradients were seen to build up in thin aluminum films during passage of electrical currents. The stresses are more compressive in the anode regions. These stress gradients seem to be a concomitant of the backflow responsible for the reported threshold in electromigration, and can probably be correlated quantitatively with it.
CH. Darwin, L’Origine des espèces (Verviers 1973), 571 p. (1973)

info:eu-repo/semantics/published
Epigenetic Features of Human Mesenchymal Stem Cells Determine Their Permissiveness for Induction of Relevant Transcriptional Changes by SYT-SSX1 (2009)

Our observations suggest that epigenetic features may define the cellular microenvironment in which SYT-SSX displays its functional effects.
Charged Macromolecules in External Fields. 2. Preliminary Remarks on the Cylinder (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharged Macromolecules in External Fields. 2. Preliminary Remarks on the CylinderMarshall FixmanCite this: Macromolecules 1980, 13, 3, 711–716Publication Date (Print):May 1, 1980Publication History Published online1 May 2002Published inissue 1 May 1980https://pubs.acs.org/doi/10.1021/ma60075a043https://doi.org/10.1021/ma60075a043research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of englitazone on K<sub>ATP</sub> and calcium‐activated non‐selective cation channels in CRI‐G1 insulin‐secreting cells (1997)

1. The effects of englitazone sodium, an antidiabetic agent, on ion channel activity in the CRI-G1 insulin secreting cell line was examined by use of the patch clamp technique. 2. Application of englitazone to the outside of CRI-G1 cells in the whole-cell recording configuration produced concentration-dependent inhibition of KATP currents with an IC50 value of 8 microM. The inhibition of the K+ current was not affected by the removal of Mg2+ ions from or the addition of trypsin to the solution bathing the intracellular surface of the cell membrane. 3. Englitazone also inhibited KATP channel activity in recordings from inside out excise membrane patches. The concentration-dependence of inhibition was identical to that observed in whole-cell recordings and was voltage-independent. Single channel recordings confirmed that neither the absence or presence of Mg2+ ions nor the addition of trypsin at the intracellular surface of the membrane influenced the inhibition of KATP channels by englitazone. 4. Englitazone also inhibited Ca(2+)-activated non-selective cation (NSCa) channels in inside-out patches in a concentration-dependent and voltage-independent manner with an IC50 value of 10 microM. In comparison, the non-sulphonylurea KATP channel blocker ciclazindol produced a slight voltage-dependent inhibition of the NSCa channel at a concentration of 20 microM. 5. In whole-cell recordings englitazone, at a relatively high concentration (50 microM) in comparison with that required to block KATP and NSCa channels, inhibited voltage-activated Ca2+ currents by 33% but did not inhibit voltage-activated K+ and Na+ currents. 6. It is concluded that englitazone is a novel blocker of NSCa and KATP channels. The inhibition of KATP channels occurs following procedures that dissociate sulphonylurea receptor coupling to the channel. The equipotent and voltage-independent inhibition of NSCa and KATP channels by englitazone may indicate a common mechanism of block.
Comparison of the axial resolution of practical Nipkow‐disk confocal fluorescence microscopy with that of multifocal multiphoton microscopy: theory and experiment (2002)

We compare the axial sectioning capability of multifocal confocal and multifocal multiphoton microscopy in theory and in experiment, with particular emphasis on the background arising from the cross-talk between adjacent imaging channels. We demonstrate that a time-multiplexed non-linear excitation microscope exhibits significantly less background and therefore a superior axial resolution as compared to a multifocal single-photon confocal system. The background becomes irrelevant for thin (< 15 microm) and sparse fluorescent samples, in which case the confocal parallelized system exhibits similar or slightly better sectioning behaviour due to its shorter excitation wavelength. Theoretical and experimental axial responses of practically implemented microscopes are given.
Human Immunodeficiency Viruses (1999)

This chapter covers: human parvovirus; B19; erythrovirus; pathogenesis; epidemiology; clinical features; diagnosis; treatment; and prevention.
Comparison of short-term diet and exercise on insulin action in individuals with abnormal glucose tolerance (1999)

The effects of a 10-day low-calorie diet (LCD; n = 8) or exercise training (ET; n = 8) on insulin secretion and action were compared in obese men (n = 9) and women (n = 7), aged 53 +/- 1 yr, with abnormal glucose tolerance by using a hyperglycemic clamp with superimposed arginine infusion and a high-fat drink. Body mass (LCD, 115 +/- 5 vs. 110 +/- 5 kg; ET, 111 +/- 7 vs. 109 +/- 7 kg; P < 0. 01) and fasting plasma glucose (LCD, 115 +/- 10 vs. 99 +/- 4 mg/dl; ET, 112 +/- 4 vs. 101 +/- 5 mg/dl, P < 0.01) and insulin (LCD, 23.9 +/- 5.6 vs. 15.2 +/- 3.9 microU/ml; ET, 17.6 +/- 1.9 vs. 13.9 +/- 2. 4 microU/ml; P < 0.05) decreased in both groups. There was a 40% reduction in plasma insulin during hyperglycemia (0-45 min) after LCD (peak: 118 +/- 18 vs. 71 +/- 14 microU/ml; P < 0.05) and ET (69 +/- 14 vs. 41 +/- 7 microU/ml; P < 0.05) and trends for reductions during arginine infusion and a high-fat drink. The 56% increase in glucose uptake after ET (4.95 +/- 0.90 vs. 7.74 +/- 0.82 mg. min-1. kg fat-free mass-1; P < 0.01) was significantly (P < 0.01) greater than the 19% increase (5.72 +/- 1.12 vs. 6.80 +/- 0.94 mg. min-1. kg fat-free mass-1; P = not significant) that occurred after LCD. The marked increase in glucose disposal after ET, despite lower insulin levels, suggests that short-term exercise is more effective than diet in enhancing insulin action in individuals with abnormal glucose tolerance.
CORE: Augmenting regenerating-coding-based recovery for single and concurrent failures in distributed storage systems (2013)

Data availability is critical in distributed storage systems, especially when node failures are prevalent in real life. A key requirement is to minimize the amount of data transferred among nodes when recovering the lost or unavailable data of failed nodes. This paper explores recovery solutions based on regenerating codes, which are shown to provide fault-tolerant storage and minimum recovery bandwidth. Existing optimal regenerating codes are designed for single node failures. We build a system called CORE, which augments existing optimal regenerating codes to support a general number of failures including single and concurrent failures. We theoretically show that CORE achieves the minimum possible recovery bandwidth for most cases. We implement CORE and evaluate our prototype atop a Hadoop HDFS cluster testbed with up to 20 storage nodes. We demonstrate that our CORE prototype conforms to our theoretical findings and achieves recovery bandwidth saving when compared to the conventional recovery approach based on erasure codes.
Direct Electrical Measurement of the Self-Assembled Nickel Silicide Nanowire (2006)

We present results from the direct electrical measurement of an as-grown nanowire. The nickel silicide (NiSi) nanowire was spontaneously grown across a trench between two electrodes used for measurement. The NiSi nanowire, 58 nm in diameter and 2.9 microm in length, showed a low resistance characteristic of 147.9 Omega. This unique method is straightforward and does not require removal of a grown nanowire to be moved into a measurement environment.
Polymer Adsorption at the Ocular Surface (1975)

A new method for measuring ocular adsorption of polymers in solution and their resistance to removal by rinsing has been developed. The adsorptive properties of artificial tear solutions and mucin have been determined. Several solutions display properties similar to mucin and two seem to resist removal by rinsing.
The Anodic Oxidation of GaAs in Aqueous H[sub 2]O[sub 2] Solution (1973)

The characteristics of anodization at constant applied voltage, V, in a concentrated (30%) electrolyte are examined in detail. Uniform oxides, with a refractive index of 1.8 and oxide thickness, t, proportional to V, are grown over the pH range 1–6. The pH can be adjusted by the addition of or to the electrolyte but the presence of other common acids at concentrations of a few parts per million can transform the anodization process into an etching procedure. In 10 min anodizations at of oxide are grown and are consumed on chemically polished surfaces (for ). The resistance of the electrolyte causes significant voltage drops in the electrolyte at all pH values and limits the initial current flow. Most of the oxide is grown during the initial anodization (typically in the first minute) where the current is decreasing rapidly with time and the voltage drop across the oxide is increasing. The oxide is insoluble in the but is soluble in most other acids and bases. Limited MOS measurements yield a dielectric constant of 5.4 and a breakdown field of . The use of the oxide as a mask for chemical etching was demonstrated by forming passive optical waveguides in epitaxial layers.
CTE characterization of ZERODURÂ® for the ELT century (2009)

This review paper summarizes the extensive investigations that have been performed at SCHOTT to achieve a deeper understanding of the CTE homogeneity of ZERODUR® within single blanks and the casted formats (boules). Especially for the upcoming Extremely Large Telescope (ELT) projects like E-ELT or TMT with at least several hundreds of mirror segments the reproducibility of the mean CTE, CTE homogeneity and axial gradient is very important while keeping the CTE quality assurance process economic at the same time. Statistics of CTE homogeneity measurements on a ZERODUR® boule suitable for an economical production of ELT mirror substrates using the improved dilatometer will be presented. It will be shown, that it is possible to achieve tight CTE specifications by utilisation of processes existing at SCHOTT, while at the same time guaranteeing a long term reproducibility. The CTE measurement is optimized for a temperature interval from 0°C to 50°C. We developed a model to extrapolate the CTE behaviour to specific temperature conditions at the telescope site.
Retinal dysplasia associated with skeletal abnormalities in Labrador Retrievers. (1977)

The clinical, radiographic, and pathologic features of skeletal and ocular dysplasia in 6 Labrador Retrievers were studied. Abnormalities in the appendicular skeleton included retarded growth in the radius, ulna, and tibia; ununited and hypoplastic anconeal and coronoid processes; hip dysplasia, and delayed development of epiphyses. Ocular changes were characterized by retinal dysplasia, with retinal detachment and cataract formation. Dogs from 4 litters were affected.
Parkinson's disease and α‐synuclein expression (2011)

Genetic studies of Parkinson's disease over the last decade or more have revolutionized our understanding of this condition. α-Synuclein was the first gene to be linked to Parkinson's disease, and is arguably the most important: the protein is the principal constituent of Lewy bodies, and variation at its locus is the major genetic risk factor for sporadic disease. Intriguingly, duplications and triplications of the locus, as well as point mutations, cause familial disease. Therefore, subtle alterations of α-synuclein expression can manifest with a dramatic phenotype. We outline the clinical impact of α-synuclein locus multiplications, and the implications that this has for Parkinson's disease pathogenesis. Finally, we discuss potential strategies for disease-modifying therapies for this currently incurable disorder.
Medical Heavy Ion Accelerator Proposals (1985)

The potential efficacy of energetic, charged particles in the treatment of human disease has long been recognized. For several decades, accelerators designed primarily for research in nuclear and high energy physics have been adapted for biomedical research including radiotherapeutic treatment of human diseases such as pituitary disorders, cancer, and, more recently, arteriovascular malformations. The particles used in these treatments include pions, protons and heavier ions such as carbon, neon, silicon and argon. Maximum beam energies must be available to penetrate into an equivalent of about 30 cm of water, requiring treatment beams of 250 to 1000 MeV/nucleon. Certain special treatments of superficial melanoma, however, require that beam energies as low as 70 MeV/nucleon also be available. Intensities must be adequate to complete a 100 rad treatment fraction in about 1 minute. For most heavy ion treatments, this corresponds to 107-109 ions/second at the patient. Because this research is best conducted in a dedicated, hospital-based facility, and because of the clinical need for ultra-high reliability, the construction of new and dedicated facilities has been proposed. Heavy ion accelerators can provide a variety of ions and energies, permitting treatment plans that exploit the properties of the ion best suited to each individual treatment, and that employ radioactive beams (such as 11C and 19Ne) to precisely confirm the dose localization. The favored technical approach in these proposals utilizes a conventional, strong-focusing synchrotron capable of fast switching between ions and energies, and servicing multiple treatment rooms.