gebhart/patrepeval huggingface dataset:
Formation of Host-Guest Complexes of β-Cyclodextrin and Perfluorooctanoic Acid (2011)

Structural characterization and dynamic properties of solid-state inclusion complexes of β-cyclodextrin (β-CD) with perfluorooctanoic acid (PFOA) were investigated by (19)F/(13)C solid-state and (19)F/(1)H solution NMR spectroscopy. The complexes in the solid state were prepared using dissolution and slow cool methods, where thermal analyses (DSC and TGA), PXRD, and FT-IR results provided complementary support that inclusion complexes were formed between β-CD and PFOA with variable stoichiometry and inclusion geometry. (19)F DP (direct polarization) and (13)C CP (cross-polarization) with magic-angle spinning (MAS) solids NMR, along with (19)F/(1)H solution NMR were used to characterize the complexes in the solid and solution phases, respectively. The dynamics of the guest molecules in the inclusion complexes (ICs) were studied using variable temperature (VT) (19)F DP/MAS NMR experiments in the solid state. The guest molecules were observed to be in several different molecular environments, providing strong evidence of variable host-guest stoichiometry and inclusion geometry, in accordance with the preparation method of the complex and the conformational preference of PFOA. It was concluded from PXRD that β-CD and PFOA form inclusion complexes with "channel-type" structures. Variable spin rate (VSR) (19)F DP/MAS NMR was used to assess the phase purity of the complexes, and it was revealed that slow cooling resulted in relatively pure phases. In the solution state, (1)H and (19)F NMR complexation-induced chemical shifts (CISs) of β-CD and PFOA, respectively, provided strong support for the formation of 1:1 and 2:1 β-CD/PFOA inclusion complexes. The dynamics of the guest molecule in the β-CD/PFOA complexes in D(2)O solutions were probed using VT (19)F NMR and revealed some guest conformational and exchange dynamics as a function of temperature and the relative concentrations of the host and guest.
Multi-stream voice over IP using packet path diversity (2002)

We propose multi-stream transmission of real-time voice over best-effort packet networks such as today's Internet, where multiple redundant descriptions of the voice stream are sent over independent network paths. At the receiver, multi-stream adaptive playout scheduling is employed to improve the tradeoff among delay, late loss rate, and speech quality. Experiments over the Internet suggest largely uncorrelated statistical characteristics, such as erasure probability and delay jitter, for different network paths, which leads to a noticeable path diversity gain. We have obtained significant reductions in mean end-to-end latency and loss rates compared to FEC protected single-path transmission at the same data rate. The speech quality perceived by the receiver is evaluated using the recently standardized objective quality measure PESQ. In our experiments, we observe gains of more than 0.4 PESQ score for voice transmission with packet path diversity.
Oasa: An Active Storage Architecture for Object-based Storage System (2012)

Active storage can largely reduce the network traffic and application execution time. In this paper, we present the design and implementation of an active storage architecture called Oasa for object-based storage system. Compared with previous work, Oasa has the following features.(1) It provides a flexible and efficient way for user to process data. User functions can process data of one user object or multiple objects at a time. (2) Oasa supports multiple patterns of user functions: both the input and output of the functions can a) come from network or disk or b) go to network or disk. (3) It keeps compatible with the current T10 OSD standard and requires little extra modification to execute user functions. Using the extended OSD commands, user can conveniently create, delete, associate and execute user functions with user objects. We also evaluate the performance of Oasa by running a typical application-data selection. It is a representative data analysis application widely used in solving real problems. Experimental results show that when the proposed active storage functions are enabled for object-based storage system, the client can obtain upto 61.9% reduction of application execution time.
Murine and human in vivo penclomedine metabolism. (1996)

Penclomedine is a multichlorinated alpha-picoline derivative which has shown prominent activity in murine breast cancer models and is currently undergoing clinical development. Previous in vitro research has identified several penclomedine metabolites. In this study, human and murine in vivo penclomedine metabolism was examined. Upon i.v. administration to mice, no penclomedine was detectable in plasma at time points as early as 1 h postinfusion. The principle metabolite was demethyl-penclomedine [3, 5-dichloro-2-methoxy-4-hydroxy-6-(trichloromethyl)pyridine]. Both penclomedine and demethyl-penclomedine could be recovered from tissues. Greater than 60% of the penclomedine dose remaining in the body at 22 h was indelibly bound to tissue and plasma proteins. Urinary metabolites of penclomedine consisted mainly of penclomic acid and additional polar metabolites. The results obtained after p. o. administration were nearly identical to i.v. administration with respect to the extent, level, and type of metabolites found in the plasma, tissues, and urine and with respect to the extent of protein binding. In human subjects administered penclomedine daily for 5 consecutive days, demethyl-penclomedine could be detected in plasma and accumulated with successive doses of penclomedine, reaching peak plasma concentrations of up to 10 times that of penclomedine itself and plasma exposures of nearly 400 times that of the parent drug. It appears that patients eliminate penclomedine largely through metabolism and that this drug may be amenable to p.o. administration.
Machine learning for learning how the brain recognizes speech and language. (2010)

Over the past several decades, automatic speech recognition has made great progress through the application of statistics and machine learning, combined with perceptual and structural knowledge about speech and language, as well as its variability. This paper reviews some recent work that applies some of these approaches to cortical processing of speech and language in the human brain to better understand how it functions. Specific experiments demonstrate feasibility for the discrimination of small sets of words (83% on 10 spoken words) and semantic categories (76% on 2 categories). This speech and language information is broadly distributed both spatially and temporally across the brain.
[A case of progressive systemic sclerosis and Sjögren's syndrome complicated by parkinsonism with special reference to the beneficial effect of corticosteroid]. (1991)

A 79-year-old woman was consulted by us because of 2 years' history of difficulty in neck flexion and frozen gait. On admission, the neurological examination disclosed findings compatible with parkinsonism such as bradykinesia and muscle rigidity. In addition, she felt thirsty and hard skin, cyanosis and Raynaud phenomenon in the limbs. These were consistent with diagnosis of progressive systemic sclerosis and Sjögren's syndrome, which was then confirmed by high titers of anti-nuclear antibody and anti-ENA antibody and abnormal sialogram; marked decrease of saliva and tear secretion was demonstrated. Brain CT and angiography showed no evidence of ischemic stroke. Parkinson symptoms were not relieved by a month's treatment with L-dopa, but was improved by 3 weeks' administration of corticosteroids; the latter also provided a benefit to the poor circulation in her finger tips. Parkinsonism in the present case is likely related to Sjögren's syndrome. Our report proposes a possibility of autoimmune disease as one of underlying causes for drug-resistant parkinsonism.
The Design of Electric Power Information Equipment Management System Based on RFID Technology (2011)

This article describes an information management system for the design of equipment and carried out in the power state companies. From software design to software development, and ultimately the results of completion,this system is of integration of today&apos;s most advanced technology RFID, with a three-dimensional structure, the use of personnel to operate on it. The system has the quick search features such as faults and statistics, this can shorten the time for fault location, greatly improved work efficiency.
지연과 대역폭이 민감한 망에서의 효율적인 링크 집단화 방법 (2011)

본 논문에서는 계층적 QoS 라우팅을 위해 소스 라우팅 방식을 채택하고 있는 전달망에서 집단화된 링크 상태 정보의 정확성을 높이기 위한 서비스경계라인 근사법을 제안한다. 이 방법은 기존 집단화 과정에서 몇몇 경로 가중치들의 소멸로 높아지는 정보 왜곡을 줄이기 위해 주요 경로 가중치를 선정한 후 집단화 정보와 함께 외부망에 전달하는 것으로 지연과 대역폭을 동시에 QoS 파라미터로 갖는 집단화에 유용하다. 본 논문에서는 주요 경로 가중치를 가외치(outlier)로 정의한다. 제안 방법은 링크 당 집단화된 상태 정보를 저장하기 위해서 2k+5개의 파라미터를 갖는다. k는 가외치 개수로 가외치 선정 방법에 따라 달라진다. 모의 실험 결과 제안 방법이 가외치 선정이란 특수성 때문에 기존 방법들에 비해 1.5~2배 이상의 저장 공간을 갖지만 저장 공간과 정보 정확성 증가 비율로 고려한다면 제안 방법이 정보 정확성이 높음을 알 수 있었다.
Double bond oxidation of unsaturated fatty acids (1988)

Abstract Different oxidizing agents for performing the cleavage oxidation of the double bond of the unsaturated fatty acids are presented, and their economic performance is analyzed. Ozone and sodium hypochlorite are the most commercially efficient oxidants. Laboratory work for the oxidation of oleic acid to azelaic and pelargonic acids using hypochlorite as oxidant is described. The advantages of working in an emulsion system and using RuCl 3 as a catalyst are discussed, and a possible mechanism of the reaction is presented. A flow sheet for an industrial process based on this concept is proposed. A simulation of a plant using this technology is made by a computerized model, and the economic parameters obtained permit us to conclude that the sodium hypochlorite can be an interesting reagent for industrial oxidations of double bonds in fatty acids.
Synthesis and pharmacological properties of some 2-pyrrolidinone Mannich bases. (1983)

N-aminoalkyl derivatives of 2-pyrrolidinone (1-5) and methylene-bis-amino derivatives (7-9) as intermediary products formed during aminoalkylation were described. Compounds 2 and 3, in doses over 30 and 20 mg/kg resp., displayed analgesic properties; compound 3 exerted also a weak anti-inflammatory action (37 mg/kg po) in the carrageenin test.
Reduction of non-digestible oligosaccharides in soymilk: application of engineered lactic acid bacteria that produce alpha-galactosidase. (2004)

Human consumption of soy-derived products has been limited by the presence of non-digestible oligosaccharides (NDO), such as the alpha-galactooligosaccharides raffinose and stachyose. Most mammals, including man, lack pancreatic alpha-galactosidase (alpha-Gal), which is necessary for the hydrolysis of these sugars. However, such NDO can be fermented by gas-producing microorganisms present in the cecum and large intestine, which in turn can induce flatulence and other gastrointestinal disorders in sensitive individuals. The use of microorganisms expressing alpha-Gal is a promising solution to the elimination of NDO before they reach the large intestine. In the present study, lactic acid bacteria engineered to degrade NDO have been constructed and are being used as a tool to evaluate this solution. The alpha-Gal structural genes from Lactobacillus plantarum ATCC8014 (previously characterized in our laboratory) and from guar have been cloned and expressed in Lactococcus lactis. The gene products were directed to different bacterial compartments to optimize their possible applications. The alpha-Gal-producing strains are being evaluated for their efficiency in degrading raffinose and stachyose: i) in soymilk fermentation when used as starters and ii) in situ in the upper gastrointestinal tract when administered to animals orally, as probiotic preparations. The expected outcomes and possible complications of this project are discussed.
Mercury control in municipal waste combustors and coal‐fired utilities (1997)

Abstract Control of mercury (Hg) emissions from municipal waste combustors (MWCs) and coal‐fired utilities has attracted attention due to current and potential regulations. Among several techniques evaluated for Hg control, dry sorbent injection (primarily injection of activated carbon) has shown promise for consistently removing high levels of Hg from MWC or coal flue gas. However, the performance in terms of amount of Hg removed per amount of sorbent varies widely between the MWC and coal‐fired applications and from unit to unit. In this study, we have conducted bench‐scale experiments under conditions simulating MWCs and coal‐fired units to study Hg capture by dry sorbents. The effect of reaction temperature on the capture of different Hg species [Hg 0 and Hg(II)] by various types of dry sorbents was the focus of bench‐scale tests. An attempt has also been made in this study to compare the bench‐scale results with results obtained from pilot studies and to explain disparities in fuel‐ and unit‐specific performance. Our investigations showed that the reaction temperature and Hg species strongly affect Hg control. The results obtained in this suggested the two following mechanisms for Hg capture: Capture of Hg 0 by activated carbons is limited by sorption kinetics, and Capture of mercuric chloride (HgCl 2 ) by activated carbons is limited by collision with carbon particles.
[Complications of antitumor and antileukemic chemotherapy. 1]. (1982)

The recent development of chemotherapy in the treatment of cancer and leukemia requires that all practitioners involved have a thorough knowledge of the sometimes life-threatening side-effects of chemotherapeutic agents. All these agents, whether used alone or in a combination, carry a risk because of their lack of specificity which make active on normal cells, especially those with a rapid turn-over such as the hematopoietic cells or the cells of the digestive tract. Prior to the prescription of a chemotherapeutic regimen, the acceptable risk must always be clearly defined, according to the seriousness of the disease and to the patient's age, physical condition and psychological status. During the course continuous monitoring adjusted to the specific toxicity of the agents used is requisite. More or less prominent asthenia and weight loss are common, as the result of various physiopathological mechanisms. Digestive disorders may consist only of nausea and emesis or include mucosal lesions with diarrhea as the main feature. Vincristine and vindesine are responsible for constipation. Hepatic toxicity, which is less common, is usually due to L-asparaginase. Transient hair loss is the most frequent cutaneous side-effect. Hyperpigmentation, photosensitivity, nail lesions, cellulitis and ulcerations may occur, as well as specific lesions with bleomycin. High fever during injection often occurs with this last agent.
T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease (2008)

In HNSCC, Tr1 cell generation is promoted at the tumor site. Tr1 cells use TGF-beta and IL-10 to mediate suppression. They expand during disease progression and also following cancer therapy in patients with no evident disease.
A Comprehensive Study of Effects of Carbon Coating on Li[sub 4]Ti[sub 5]O[sub 12] Anode Material for Lithium-Ion Batteries (2010)

Carbon coating is an important technique used to improve the electrochemical performance of many electrode materials in lithium-ion batteries. In the present work, was selected as the probe material and a series of carbon-coated samples was prepared to discuss the effects of graphitization and thickness of the coated carbon layer on its rate capability for lithium-ion intercalation. The apparent diffusion coefficient and rate capability were studied by cyclic voltammetry experiments using a powder microelectrode. The results show that a higher carbon coating temperature could promote the graphitization of the surface carbon, thus enhancing the electronic conductivity of the electrodes while hindering the lithium-ion diffusion. The thickness of carbon layer is demonstrated to have a major influence on ion diffusion while slightly affecting the electronic conductivity. Considering both the electronic conductivity and ion diffusion in the carbon layer, an optimal condition for carbon coating to achieve a good rate capability is determined to be performed at with a thickness of ca. .
SINGLE-WALLED CARBON NANOTUBES: APPLICATIONS IN HIGH FREQUENCY ELECTRONICS (2006)

In this paper, we review the potential applications of single-walled carbon nanotubes in three areas: passives (interconnects), actives (transistors), and antennas. In the area of actives, potential applications include transistors for RF and microwave amplifiers, mixers, detectors, and filters. We review the experimental state of the art, and present the theoretical predictions (where available) for ultimate device performance. In addition, we discuss fundamental parameters such as dc resistance as a function of length for individual, single-walled carbon nanotubes.
Metallobiomolecules. The basis of life, the challenge of atomic spectroscopy (2004)

An outline of recent advances in metalloproteomics (structural and functional characterization of metal-binding proteins and their structural metal-binding moieties) and metallomics (characterization of the entirety of metal and metalloid species within a cell or tissue type) is presented. ICP-MS allows the specific detection of heteroelements after separation using techniques traditionally associated with biochemistry, such as gel electrophoresis or capillary chromatography. The element specificity, independence of matrix effects, and wide linear range make ICP-MS an attractive complementary technique to ESI/MALDI-MS for the analysis of sulfur-, selenium- and phosphorus-containing proteins, metal-complexes with nucleic acids, carbohydrates and proteins, and metal-tagged biomolecules in general.
Design and implementation of path generation algorithm for controlling autonomous driving and parking (2012)

The autonomous valet parking technology is a vehicle and IT convergence technology which drives automatically to the target parking lot without any human intervention. To realize auto-valet parking service, the movement of the vehicle is able to be controlled and spatial environments should be recognized in real-time by sensor fusion. Most fundamental technology for autonomous driving and parking service is to generate path to goal parking lot and generate control command continuously to follow the path. The path has to be generated as considering the dynamics of the vehicle and the driving path and the parking path are generated with different data structure and algorithm because the vehicle is able to follow the parking path which is short distance under 5km/hr slowly. And the smooth curve fitting is needed to follow the driving path but not to follow the parking path. In this paper, we have designed and implemented the path generation algorithms which are able to be followed parking after driving continuously as considering vehicle kinematics.
Enantioselective oxidation of O-methyl-N-hydroxylamines using monoamine oxidase N as catalyst (2007)

Enantioselective oxidation of racemic O-methyl-N-hydroxycyclohexylethylamine, using a variant of monoamine oxidase N (MAO-N) from Aspergillus niger, yields unreacted (R)-enantiomer (e.e. = 99%) together with the oxime exclusively in the (E)-configuration.
Pharmacokinetics and Pharmacodynamics of Recombinant Human Interferon-β in Healthy Male Volunteers (1996)

The pharmacokinetics and pharmacodynamics of recombinant human interferon-beta (rHuIFN-beta 1a) were assessed following administration to 12 healthy male volunteers. Each subject received, in a double-blind, balanced, random-order, crossover sequence, single doses of 6 MIU of rHuIFN-beta 1a (Rebif) i.v., i.m., and s.c. or matching placebo on four occasions separated by washout periods of 1 week. Blood samples were collected at preset times for the measurement of serum IFN-beta levels and of intracellular 2'-5'-oligoadenylate synthetase levels. Blood pressure, sitting heart rate, respiratory rate, oral body temperature, and tolerance were monitored regularly. All administrations of rHuIFN-beta 1a were well tolerated, although about half of the subjects had a flu-like syndrome, as expected. After i.v. bolus injection, the pharmacokinetics of rHuIFN-beta 1a were well described by a classic two-compartment model. Mean total clearance of rHuIFN-beta 1a was about 100 L.h-1. The distribution half-life was 5 min, and the terminal half-life was approximately 5 h. After i.m. or s.c. injection, serum IFN-beta profiles were rather flat, and about one sixth of the administered dose was available systemically. Extent and duration of clinical and biologic effects were independent of the route of administration and of the IFN-beta serum levels. Biologic pharmacodynamic effects persisted even when IFN-beta serum levels had returned to baseline and were still significantly elevated 3 days after a single dose. Because of the independence of the extent and duration of clinical and biologic pharmacodynamic effects from the route of administration and from the IFN-beta serum levels, the s.c route of administration is preferred in indications in which primarily an immunomodulatory action is sought. Predominantly antiviral and antiproliferative activity is enhanced by the i.v. route to provide adequate drug levels at the site of pathology, although its application is limited on practical grounds.
Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study (2018)

Pending external validation, the identified combinations could be used to identify individuals at high risk of AKI immediately after cardiac surgery and could facilitate clinical trials of renoprotective agents.
Laser Power Multiplication in a Parametric Frequency Converter with a Cavity Dumper (1981)

It is shown theoretically that by using a parametric frequency converter with a cavity dumper, power enhanced laser pulses of moderately compressed pulse-duration, shorter wavelength and broader bandwidth can be obtained efficiently from relatively long fundamentals, resulting in useful laser-fusion driver pulses.