gebhart/patrepeval huggingface dataset:
Necrotic enteritis predisposing factors in broiler chickens (2016)

Necrotic enteritis in chickens develops as a result of infection with pathogenic strains of Clostridium perfringens and the presence of predisposing factors. Predisposing factors include elements that directly change the physical properties of the gut, either damaging the epithelial surface, inducing mucus production, or changing gut transit times; factors that disrupt the gut microbiota; and factors that alter the immune status of birds. In the past research into necrotic enteritis predisposing factors was directed by the simple hypothesis that low-level colonization of C. perfringens commonly occurred within the gut of healthy chickens and the predisposing factors lead to a proliferation of those bacteria to produce disease. More recently, with an increasing understanding of the major virulence factors of C. perfringens and the application of molecular techniques to define different clades of C. perfringens strains, it has become clear that the C. perfringens isolates commonly found in healthy chickens are generally not strains that have the potential to cause disease. Therefore, we need to re-evaluate hypotheses regarding the development of disease, the origin of disease causing isolates of C. perfringens, and the importance of interactions with other C. perfringens strains and with predisposing factors. Many predisposing factors that affect the physical and immunological characteristics of the gastrointestinal tract may also change the resident microbiota. Research directed towards defining the relative importance of each of these different actions of predisposing factors will improve the understanding of disease pathogenesis and may allow refinement of experiment disease models.
Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer (1994)

The authors concluded that the immunohistochemical staining pattern of cathepsin B may be a useful predictor of survival for human lung cancer.
Construction and Photoluminescence of Monophase Hybrid Materials Derived from a Urea‐Based Bis‐Silylated Bipyridine (2008)

Abstract A urea‐based bis‐silylated bipyridine ligand derived from 4,4′‐diamino‐2,2′‐bipyridine has been prepared. Organic–inorganic hybrid materials with a high loading of lanthanide 2,2‐bipyridine moieties were obtained by using the silylated bipyridine as the only siloxane network precursor in the presence of lanthanide ions (or lanthanide complexes). The in‐situ formation of lanthanide complexes from lanthanide ions and the silylated bipyridine during the sol–gel processing was confirmed by the luminescence behavior of the obtained hybrid materials and that of the corresponding pure lanthanide complex [Ln(bpy) 2 Cl 3 · 2H 2 O]. Tris(2‐thenoyltrifluoroacetonato)europium(III) dihydrate complexes were coupled to the hybrid materials via adduct formation with the nitrogen atoms from bis‐silylated bipyridine, and the coordinated water molecules were expelled from the first coordination sphere of the lanthanide(III) ion as revealed by the much longer lifetime of the hybrid material compared with that of the pure tris(2‐thenoyltrifluoroacetonato)europium(III). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Field enhancement of Optical Nanoantenna for 0.55μm Wavelength by Using OptiFDTD Simulation (2014)

Abstract In this research we choose the design of Dipole nanoantenna with the adoption of finite difference time domain method. The design result of 0.55μm optical antenna and its performance are presented. The optimal parameters are: [Gap=(10, 15, 20, 25, 30)nm & Length=(200, 240, 280, 320, 360)nm]. The influence of the geometrical parameters (gap dimension , nanoantenna length) on the antenna field enhancement and spectral response is discussed. We found the field enhancement be bigger when the gap be very small at dipole nanoantenna, where in the Gap=10nm the field enhancement more than in the Gaps (15, 20, 25, 30)nm.
A New Up-Scaled Wormhole Model Grounded on Experimental Results and in 2-Scale Continuum Simulations (2019)

Abstract The optimum design of matrix acidizing treatments in carbonate reservoirs requires accurate modeling of wormhole propagation. While there are several wormhole correlation models available, most are developed based on small core scale experiments, and result in significant deviation when upscaled to field treatment design. There also exists simulation models (e.g. Two-Scale Continuum or Pore Network models). These models are not practical for field design because of the extensive computation effort involved. Large variations in the wormholing behavior are observed in laboratory experiments using different core sizes and geometries (radial flow versus linear flow). This variation is not captured in the previous models. This work proposes a new multiscale wormhole model that represents the physics of wormholing behavior in matrix acidizing of carbonates both at core and field scales. The derivation of the new semi-empirical model is formulated to represent the experimental data for different core dimensions and flow geometries, as well as field results. In core flooding experiments with different core sizes, the obtained pore volumes to breakthrough and optimal injection velocity are different for each core size. The same behavior is observed in numerical simulations using the Two-Scale Continuum model. That behavior is correctly calculated with the proposed model, which accounts for the dimensions in a function with dependence of the correlation parameters on the wormholed region scale and geometry. Upscaling procedures to linear, radial, elliptical, spherical, and ellipsoidal geometries are presented. The model's results are validated by the Two-Scale Continuum numerical simulations for both linear and radial flow and verified with experimental results with different core sizes and geometries (both linear and radial flow). We further developed the model for field application, and procedure of using the model is illustrated in the paper. The different flow geometries allow predicting the acidizing behavior in common completions, such as openhole, cased and perforated, and limited entry. The model prediction compares very well to the outcome of field cases. The new model reproduces the fractal behavior of the dominant wormhole growth above optimal injection rate, and predicts the injection pressure dependence on time as measured experimentally. The model correctly captured the physics of wormhole propagation phenomenon.
Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments (1981)

Mid-aged rats were either adrenalectomized and chronically maintained, or left intact and treated daily for a 9- to 10-month period with a potent analog of the peptide adrenocorticotropin (residues 4 to 9), which has some stimulant properties, or with the neural stimulant pentylenetetrazole. All three treatments reduced hippocampal morphologic correlates of brain aging (neuronal loss, glial reactivity). The pentylenetetrazole and peptide treatments also improved reversal learning. These results suggest that certain endogenous peptides, with stimulant properties, may also exert long-term, trophic effects on brain structure and function.
Comprehensive Analysis of Ultrasonic Vocalizations in a Mouse Model of Fragile X Syndrome Reveals Limited, Call Type Specific Deficits (2012)

Fragile X syndrome (FXS) is a well-recognized form of inherited mental retardation, caused by a mutation in the fragile X mental retardation 1 (Fmr1) gene. The gene is located on the long arm of the X chromosome and encodes fragile X mental retardation protein (FMRP). Absence of FMRP in fragile X patients as well as in Fmr1 knockout (KO) mice results, among other changes, in abnormal dendritic spine formation and altered synaptic plasticity in the neocortex and hippocampus. Clinical features of FXS include cognitive impairment, anxiety, abnormal social interaction, mental retardation, motor coordination and speech articulation deficits. Mouse pups generate ultrasonic vocalizations (USVs) when isolated from their mothers. Whether those social ultrasonic vocalizations are deficient in mouse models of FXS is unknown. Here we compared isolation-induced USVs generated by pups of Fmr1-KO mice with those of their wild type (WT) littermates. Though the total number of calls was not significantly different between genotypes, a detailed analysis of 10 different categories of calls revealed that loss of Fmr1 expression in mice causes limited and call-type specific deficits in ultrasonic vocalization: the carrier frequency of flat calls was higher, the percentage of downward calls was lower and that the frequency range of complex calls was wider in Fmr1-KO mice compared to their WT littermates.
Do knowledge and attitudes about influenza and its immunization affect the likelihood of obtaining immunization? (1992)

A telephone survey was conducted on 190 patients in Barcelona, Spain, at high-risk for influenza to evaluate the relationship between their knowledge and attitudes toward influenza and influenza immunization and whether they received the immunization. A discriminant function correlates (r = 0.86) with the immunization behavior and predicts the behavior before flu immunization in 84% of cases if we know the previous immunization behavior and adequately classifies the behavior in 82% if we don't know it (r = 0.75). Modifiable factors that predict immunization are self-identification as high-risk, belief that the immunization will not cause discomfort, intention to be immunized, and physician assigned. Those not immunized had a prevalent feeling that the shot is not effective, that they are not susceptible to the illness, and that the health center does not offer satisfactory organization to provide immunization. Furthermore, they felt that they had received controversial information through the mass media. We therefore believe that health education activities regarding influenza immunization should be specifically directed to increasing awareness of those who belong to a high-risk group, as well as to emphasizing susceptibility to the illness and the innocuousness of the immunization.
Effect of contact lens wear on photorefractive keratectomy. (1993)

This study compares refractive effect and epithelial healing after photorefractive keratectomy among patients who wore contact lenses before surgery versus those who wore glasses before surgery. Data were reviewed on 130 photorefractive keratectomy cases at the 1-week, 2-week, and 4- to 6-month postoperative visits. The patients were divided into three groups based on whether or not they wore contact lenses before surgery: 1) rigid gas permeable lens wearers; 2) soft lens wearers; 3) no contact lens wear. There were no significant differences in epithelial healing among the groups. Some regression of refractive effect was observed both in mean spherical equivalent and in mean keratometry in all the groups from 2 weeks to 6 months postoperatively. There was no significant difference in the regression of each group. In addition, the changes of spherical equivalent and keratometry before surgery and 4 to 6 months after surgery were compared among the groups with no significant differences. Based upon these results, we conclude that contact lens wearing does not seem to influence epithelial healing after photorefractive keratectomy surgery and also does not affect the refractive effect in the early postoperative period.
ORC5L, a New Member of the Human Origin Recognition Complex, Is Deleted in Uterine Leiomyomas and Malignant Myeloid Diseases (1998)

A new member of the human origin recognition complex (ORC) was cloned and identified as ORC5L. HsORC5p is a 50-kDa protein whose sequence is 38% identical and 62% similar to ORC5p from Drosophila melanogaster. Two alleles of ORC5L were identified, one with and one without an evolutionarily conserved purine nucleotide binding motif. HsORC5p is precipitated from cell extracts with HsORC2p and HsORC4p, indicating that it is part of the putative human ORC. The bulk of HsORC5p is in an insoluble nuclear fraction, whereas the other known human ORC subunits (HsORC1p, HsORC2p, and HsORC4p) are easily extracted in the nuclear-soluble fractions and in S100 (HsORC1p). In addition, we identified an alternatively spliced mRNA from the same locus (HsORC5T). HsORC5Tp also formed a complex with HsORC4p but not with HsORC2p, suggesting it may play a regulatory role in the assembly of different ORC subcomplexes. HsORC5, HsORC5T, and HsORC4 transcripts are abundant in spleen, ovary, and prostate in addition to tissues with high levels of DNA replication like testes and colon mucosa, implicating the human ORC proteins in functions besides DNA replication. Finally, the gene for ORC5L is located at chromosome 7, band q22, in the minimal region deleted in 10% of uterine leiomyomas and in 10-20% of acute myeloid leukemias and myelodysplastic syndromes.
Multi-wavelength diode-pumped broadband Raman amplifiers (2002)

Recent development on diode pumped Raman fibre amplifiers for WDM fibre networks are reviewed. Design issues of multiwavelength pumping scheme to obtain a broadband, flat and high gain by using diode lasers, are discussed with simulation and experimental results.
Developments in protoplast fusion in fungi. (1987)

Protoplasts have proved to be valuable tools in fungal genetics. Removal of the cell wall is clearly very significant because this organelle has an important role in cell-cell interactions. Using the molecular 'glue' polyethylene glycol or electrofusion methods, protoplasts can be fused in intraspecies and interspecies and intergeneric combinations. The technique has therefore opened up an important new area of study which has both fundamental and applied importance.
Design of packet transmission scheduler for high speed downlink packet access systems (2003)

This paper proposes a packet scheduler for high speed downlink packet access (HSDPA) systems. In designing the scheduler, we consider the delay constraint of packets from the user's point of view and throughput performance in whole systems, as well as the throughput fairness between mobiles. The performance of the proposed scheme is evaluated by simulation.
Fabrication of ZnO-based film bulk acoustic resonatordevices using W/SiO <sub>2</sub> multilayer reflector (2000)

A ZnO-based film bulk acoustic resonator (FBAR) with a W/SiO2 multilayer reflector has been fabricated using a two-step ZnO deposition. The FBAR showed a large return loss of 35 dB at ~2 GHz and a high quality factor (high-Q) of ~4000. The resonance characteristics depended largely on the multilayer reflector and ZnO film.
Diazirines. I. Some Observations on the Scope of the Ammonia-Hydroxylamine-O-sulfonic Acid Diaziridine Synthesis. The Preparation of Certain Steroid Diaziridines and Diazirines (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiazirines. I. Some Observations on the Scope of the Ammonia-Hydroxylamine-O-sulfonic Acid Diaziridine Synthesis. The Preparation of Certain Steroid Diaziridines and DiazirinesRobert F. R. Church, Andrew S. Kende, and Martin J. WeissCite this: J. Am. Chem. Soc. 1965, 87, 12, 2665–2671Publication Date (Print):June 1, 1965Publication History Published online1 May 2002Published inissue 1 June 1965https://doi.org/10.1021/ja01090a025RIGHTS & PERMISSIONSArticle Views1091Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (793 KB) Get e-Alertsclose Get e-Alerts
Transcriptional Regulation of The Human Monocyte Chemoattractant Protein-1 Gene (1997)

Human monocyte chemoattractant protein-1 (human MCP-1) mRNA accumulated in THP-1 cells 2 h after lipopolysaccharide (LPS) stimulation. DNase I footprinting revealed that LPS stimulation induced protein binding to the two closely located NF-kappaB sites, A1 and A2. By electrophoretic gel mobility shift assay and supershift assay, the binding of (p65)2, c-Rel/p65, p50/p65, and p50/c-Rel to the A2 oligonucleotide probe was detected after LPS stimulation. In contrast, 12-o-tetradecanoylphorbol 13-acetate did not induce a significant amount of MCP-1 mRNA in THP-1 cells 2 h after stimulation, and only p50/p65 bound to the A2 probe. trans-Activity of each NF-kappaB/Rel dimer was investigated by transfecting P19 cells with p65, p50, and/or c-Rel expression vectors, and a luciferase construct containing the enhancer region of the human MCP-1 gene. Expression of recombinant p65 or p65 and c-Rel resulted in elevated luciferase activities, indicating that (p65)2 and c-Rel/p65 had trans-activity. The binding of (p65)2 and/or c-Rel/p65 to the A2 probe was also detected from 12-o-tetradecanoylphorbol 13-acetate-stimulated HeLa, HOS, and A172 cells in which expression of MCP-1 mRNA was elevated. Finally, the role of the A1 site was investigated. Both (p65)2 and c-Rel/p65 bound to the A1 probe by electrophoretic mobility shift assay and a mutation in the A1 or A2 site resulted in a loss of the enhancer activity. These results suggest that the binding of (p65)2 and c-Rel/p65 to the A1 and A2 sites of this gene is important for the tissue- and stimulus-specific transcription of the human MCP-1 gene.
Computer simulation of a polymer electrolyte: Lithium iodide in amorphous poly(ethylene oxide) (1995)

Systems of lithium iodide dissolved in poly(ethylene oxide), which are prototypes of polymer electrolytes used, for example, in batteries were studied by means of molecular dynamics simulations. Investigations were aimed at the molecular driving force behind the salt uptake, the mechanism of ion transport, participation of the polymer in ion transport, ion clustering, change of polymer properties by the presence of ions, and ionic conductivity. Particular attention has been given to the differences in behavior between (previously studied) neutral and ionic species dissolved in polymers.
Reactions of Elemental Sulfur. IV. Catalytic Effects in the Reaction of Sulfur with Triphenylphosphine (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Elemental Sulfur. IV. Catalytic Effects in the Reaction of Sulfur with TriphenylphosphinePaul D. Bartlett, Eugene F. Cox, and Robert Earl DavisCite this: J. Am. Chem. Soc. 1961, 83, 1, 103–109Publication Date (Print):January 1, 1961Publication History Published online1 May 2002Published inissue 1 January 1961https://pubs.acs.org/doi/10.1021/ja01462a020https://doi.org/10.1021/ja01462a020research-articleACS PublicationsRequest reuse permissionsArticle Views1190Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nanoscale Deposition of Single‐Molecule Magnets onto SiO<sub>2</sub> Patterns (2007)

Manipulation of molecules with nanoscale accuracy is important in nanotechnology. In the novel process reported here, electrostatic interactions direct the deposition of polycationic Mn12 single-molecule magnets into a predefined region of a 1 cm2 silicon chip with 40 nm accuracy (see figure). The process is based on the integration of local oxidation nanolithography with surface functionalization of the Si substrate. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c1999_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Regenerable Bacterial Membrane Electrode for L-Aspartate (1977)

Abstract The use of living bacteria held at the surface of an NH3 gas sensing membrane electrode permits the construction of a potentiometric sensor for L-aspartate. It is shown that the bacterial electrode, when stored in nutrient media, can have an appreciably longer lifetime than the corresponding electrode based on isolated L-aspartase enzyme. The response range and dynamic properties of the bacterial electrode are comparable to those of the enzyme electrode.
Addition reactions of heterocyclic compounds. Part XLIV. The synthesis and photoisomerism of some quinolizine esters (1971)

Deuterium labelling experiments have shown that the thermal conversion of tetramethyl 4aH-benzo[c]quinolizine-1,2,3,4-tetracarboxylate into the 1H-isomer is an intramolecular process, whereas the photochemical conversion in methanol involves deuterium exchange with the solvent. Mechanisms are discussed.Dimethyl acetylenedicarboxylate, when treated with 2-isopropyl-, 2-styryl-, and 2,3-trimethylene-quinoline, and with 1,2,3,4-tetrahydroacridine gave 4a-alkyl-4aH-benzo[c]quinolizines and other products. Irradiation of these quinolizines, and other quinolizines with bridgehead hydrogen atoms or alkyl groups and obtained from pyridines and isoquinoline, caused migration of the bridgehead group to position 1 in sterically favourable cases. Pyrroloazepines were also formed in some instances.
An integrated time-driven scheduler for the ARTS kernel (2003)

The authors have developed a novel scheduling model, called integrated time-driven scheduler (ITDS), for the ARTS kernel, which is a distributed real-time kernel currently under development. The ITDS model is based on the integration of hard real-time scheduling policies and a value-function-based time-driven scheduler. For the hard real-time tasks, the model can be used to predict whether the deadlines can be met or not at the system design stage. For the soft real-time tasks, the model schedules the tasks based on their value functions, which represent the semantic importance value as a function of time. A description is given of the ITDS model and the implementation of the ITDS scheduler, which is based on the policy/mechanism separation concept. They also discuss the development environment, including the real-time tool set and the experimental performance of the ITDS scheduler.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>