gebhart/patrepeval huggingface dataset:
Intercellular Communication in Marine<i>Vibrio</i>Species: Density-Dependent Regulation of the Expression of Bioluminescence (2014)

This chapter focuses on the different molecular mechanisms two model luminous bacteria, Vibrio fischeri (a symbiont) and V. harveyi (a free-living microbe), use for regulating lux expression. Expression of luminescence in most bacteria is tightly regulated by the density of the population. In V. fischeri, the regulatory genes involved in density-dependent control of luminescence are adjacent to the luxCDABEG operon encoding the luciferase enzymes. The regulatory genes that control luminescence in V. harveyi are different from those of V. fischeri. One complementation group of V. harveyi dim mutants could be restored to full light production by a family of recombinant cosmids containing a subset of common restriction fragments. Initial HAI-1 and HAI-2 signal recognition by LuxN and LuxQ could activate a series of phosphotransfer reactions. Two-component circuits have been characterized in which a single protein contains both a sensor kinase and a response regulator domain (similar to LuxN and LuxQ) and a second protein contains both a response regulator domain and a DNA binding motif (similar to LuxO). The differences between the regulatory circuits controlling density-dependent expression of luminescence in V. fischeri and V. harveyi are striking. Subsequent mutations and gene duplications and rearrangements generated new and multiple autoinducers, receptivities, and regulatory connections, finally resulting in a bacterium with the properties of V. harveyi.
Directed Growth of Ordered Arrays of Small‐Diameter ZnO Nanowires (2004)

Array growth of small-diameter (10–15 nm) zinc oxide (ZnO) nanowires by patterning and template-directed growth methods is reported. The ZnO nanowire arrays (see Figure) were patterned over large areas (∼1 cm2), and exhibited photoluminescence—a characteristic of highly crystalline materials.
Prenatal smoke exposure, <scp>DNA</scp> methylation, and childhood atopic dermatitis (2013)

The effect of prenatal tobacco smoke exposure on the risk for AD may be mediated through DNA methylation.
STRIPE-a high-speed VLSI bipolar technology featuring self-aligned single-poly base and submicron emitter contacts (1990)

Experimental results are presented for a high-performance silicon bipolar transistor structure utilizing a single layer of polysilicon for both the base and emitter contacts. This structure, called STRIPE (self-aligned trench-isolated polysilicon electrodes), provides a 2.0-μm emitter/base polysilicon contact separation. A 0.4-μm emitter width is achieved with conventional 0.8-μm optical lithography. These dimensions are comparable to those achievable with double-poly structures. Using the STRIPE structure, transistors have been fabricated with cutoff frequency as high as 33.8 GHz
A study of solvent and substituent effects on the redox potentials and electron-transfer rate constants of substituted iron meso-tetraphenylporphyrins (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA study of solvent and substituent effects on the redox potentials and electron-transfer rate constants of substituted iron meso-tetraphenylporphyrinsK. M. Kadish, M. M. Morrison, L. A. Constant, L. Dickens, and D. G. DavisCite this: J. Am. Chem. Soc. 1976, 98, 26, 8387–8390Publication Date (Print):December 1, 1976Publication History Published online1 May 2002Published inissue 1 December 1976https://pubs.acs.org/doi/10.1021/ja00442a013https://doi.org/10.1021/ja00442a013research-articleACS PublicationsRequest reuse permissionsArticle Views870Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MicroRNA-212 displays tumor-promoting properties in non-small cell lung cancer cells and targets the hedgehog pathway receptor <i>PTCH1</i> (2012)

Dysexpression of microRNAs has been found in many tumors, including lung cancer. The hedgehog (Hh) signaling pathway plays an important role during normal development, and the abnormal regulation of its members has also been related to many tumors. However, little is known about the relationship between microRNA and the Hh pathway. In this paper, we report microRNA-212 (miR-212) playing a role in non-small cell lung cancer (NSCLC) and targeting PTCH1, a receptor of the Hh pathway. We found that miR-212 was up-regulated when cells were treated with 4ß-12-O-tetradecanoylphorbol-13-acetate (TPA). We ectopically expressed miR-212 in NSCLC cell lines to examine the influence of miR-212 overexpression. The results showed that overexpression of miR-212 in NSCLC cells promoted cell cycle progression and cell proliferation, migration, and invasion. The promoting effects of miR-212 on cell proliferation, migration, and invasion were partially reversed by the miR-212 inhibitor anti-miR-212. These results suggested that miR-212 might have tumor-promoting properties. Potential targets of miR-212 were predicted, and we showed tumor suppressor PTCH1 was a functional target of miR-212. PTCH1 may be responsible for the effect of miR-212 on cell proliferation. Altogether, our results indicated that miR-212 was involved in tumorigenesis, and the oncogenic activity of miR-212 in NSCLC cells was due, in part, to suppression of PTCH1.
Quantitative Analysis of OCT Characteristics in Patients with Achromatopsia and Blue-Cone Monochromatism (2006)

Quantitative OCT image analysis reveals distinct patterns for controls subjects and patients with ACH and BCM, respectively. Quantitative analysis of OCT imaging can be useful in differentiating retinal diseases affecting photoreceptors. Foveal thickness is similar in both normal subjects and patients with ACH but is decreased in patients with BCM.
Multiple Molecular Forms of Acid-Stable Plasmin InhibitorDerived from Human Urinary Trypsin Inhibitor (1983)

It was found that cyanogen bromide (BrCN) treatment of the highly purified human urinary trypsin inhibitors (H-UTI; specific activity 1,897 U/mg protein, and L-UTI; specific activity 1,850 U/mg protein) readily produced new plasmin inhibitors with almost no loss of UTI activity. Five multiple forms of chemically cleaved inhibitors (UTIB-I, UTIB-II, UTIB-III, UTIB-IV and UTIB-V) could be isolated from BrCN-treated L-UTI by isoelectric focusing and gel filtration. These inhibitors were very acid-stable and their isoelectric points (pI) were 4.5, 4.6, 4.9, 5.1 and 6.4, respectively. The molecular weights by SDS-polyacrylamide gel electrophoresis were almost the same at about 23,000 +/- 3,000. Although these inhibitors showed both anti-plasmin and anti-trypsin activities, much higher anti-plasmin/anti-trypsin activities were observed in the cleaved inhibitors than in the parent UTI. They competitively inhibited human plasmin with Ki values of 3.0-4.1 X 10(-8) mol/l (H-D-Val-Leu-Lys-pNA substrate).
NEURONET: a distributed real-time system for monitoring neurophysiologic function in the medical environment (1991)

A specific medical application, namely repair of a narrow aorta in children, served by Neuronet, a large software package integrated with 80 computer workstations and instrumentation, is considered to demonstrate the offline and real-time capabilities of the package. An overview of the system is given, and a case example is presented. The system's remote capabilities, signal processing, user interface, and database are discussed. Reliability and upgradeability are considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The subjective effect of BRIR length perceived headphone sound externalisation and tonal colouration (2014)

Binaural room impulse responses (BRIRs) of various lengths were convolved with stereophonic audio signals. Listening tests were conducted to assess how the length of BRIRs affected the perceived externalisation effect and tonal colouration of the audio. The results showed statistically significant correlations between BRIR length and both externalisation and tonal colouration. Conclusions are drawn from this and in addition, reasoning, a critical evaluation and suggested further work are suggested. The experiment provides the basis for further development of an effective and efficient externalisation algorithm.
Solid-state Marx type circuit for the ISOLDE voltage target modulator (2009)

This paper describes a circuit topology proposed to replace the actual modulator circuit that supplies the 60 kV target voltage potential for the ion acceleration, at the ion source of the On-Line Isotope Mass Separator ISOLDE, located at the Proton-Synchrotron Booster PSB of the European Organisation for Nuclear Research CERN, the stability of which is critical for the mass resolution of the downstream separator. The proposed circuit uses two solid state switches, based on the Marx generator concept, to reduce the stress on the semiconductors, operating as a serial and parallel switch in order to fulfil the requirements of the target. The preliminary results of a 10 kV laboratory testing, using 1200 V IGBTs and capacitors in the two, ten stages, solid-state Marx generators are reported and discussed. (4 pages)
A novel point cloud registration using 2D image features (2017)

Since a 3D scanner only captures a scene of a 3D object at a time, a 3D registration for multi-scene is the key issue of 3D modeling. This paper presents a novel and an efficient 3D registration method based on 2D local feature matching. The proposed method transforms the point clouds into 2D bearing angle images and then uses the 2D feature based matching method, SURF, to find matching pixel pairs between two images. The corresponding points of 3D point clouds can be obtained by those pixel pairs. Since the corresponding pairs are sorted by their distance between matching features, only the top half of the corresponding pairs are used to find the optimal rotation matrix by the least squares approximation. In this paper, the optimal rotation matrix is derived by orthogonal Procrustes method (SVD-based approach). Therefore, the 3D model of an object can be reconstructed by aligning those point clouds with the optimal transformation matrix. Experimental results show that the accuracy of the proposed method is close to the ICP, but the computation cost is reduced significantly. The performance is six times faster than the generalized-ICP algorithm. Furthermore, while the ICP requires high alignment similarity of two scenes, the proposed method is robust to a larger difference of viewing angle.
Vaccines against morphine/heroine and its use as effective medication for preventing relapse to opiate addictive behaviors (2009)

Current pharmacotherapies for treating morphine/heroin dependence are designed to substitute or block addiction by targeting the drug itself rather than the brain. The heroin addict is still being exposed to addictive opiates, and consequently may develop tolerance to and experience withdrawal and drug's toxic effects from the treatment with high incidence of relapse to addictive drug consumption. As for other drugs of abuse, an alternative approach for morphine/heroin addiction is an antibody-based antagonism of heroin's brain entry. This review summarizes the literature examining important aspects of neurobiological and pharmacological processes involved in opiate dependence. Thereafter, classical pharmacological interventions for opiate dependence treatment and its major clinical limitations are reviewed. Finally, relevant preclinical studies are examined for comparisons in the design, use, immunogenic profile and efficacy of several models of morphine/heroin vaccine as immunologic interventions on the pharmacokinetics and behavioral of morphine/heroin in the rat as animal model.
Use of Real-Time Hybrid Simulation to Evaluate the Performance-Based Seismic Design of Steel MRFs with Compressed Elastomer Dampers (2010)

This paper presents an experimental program using real-time hybrid simulation to verify the performance-based seismic design of a two story, four-bay steel moment resisting frame (MRF) building with compressed elastomer dampers. The laboratory specimens, referred to as experimental substructures, are two individual compressed elastomer dampers, while the remaining part of the building is modeled as an analytical substructure. The proposed experimental technique enables an ensemble of ground motions to be applied to the building, resulting in various levels of damage, without the need to repair the experimental substructures since the damage is within the analytical substructure. Statistical experimental response results incorporating the ground motion variability show that an MRF with compressed elastomer dampers can be designed to perform better than a conventional steel special moment resisting frame (SMRF), even when the MRF with dampers is significantly lighter in weight than the conventional SMRF.
Nuclear Accumulation of p53 Protein Is Mediated by Several Nuclear Localization Signals and Plays a Role in Tumorigenesis (1990)

The basic carboxy terminus of p53 plays an important role in directing the protein into the nuclear compartment. The C terminus of the p53 molecule contains a cluster of several nuclear localization signals (NLSs) that mediate the migration of the protein into the cell nucleus. NLSI, the most active domain, is highly conserved in genetically diverged species and shares perfect homology with consensus NLS sequences found in other nuclear proteins. The other two NLSs, II and III, appear to be less effective and less conserved. Although nuclear localization is dictated primarily by the NLSs inherent in the primary amino acid sequence, the actual nuclear homing can be modified by interactions with other proteins expressed in the cell. Comparison between wild-type p53 and naturally occurring mutant p53 showed that both protein categories could migrate into the nucleus of rat primary embryonic fibroblasts by essentially similar mechanisms. Nuclear localization of both proteins was totally dependent on the existence of functional NLS domains. In COS cells, however, we found that NLS-deprived wild-type p53 molecules could migrate into the nucleus by complexing with another nuclear protein, simian virus 40 large-T antigen. Wild-type and mutant p53 proteins differentially complexed with viral or cellular proteins, which may significantly affect the ultimate compartmentalization of p53 in the cell; this finding suggests that the actual subcellular compartmentalization of proteins may differ in various cell type milieux and may largely be affected by the ability of these proteins to complex with other proteins expressed in the cell. Experiments designed to test the physiological significance of p53 subcellular localization indicated that nuclear localization of mutant p53 is essential for this protein to enhance the process of malignant transformation of partially transformed cells, suggesting that p53 functions within the cell nucleus.
In vitro aggregation assays for the characterization of α-synuclein prion-like properties (2014)

Aggregation of α-synuclein plays a crucial role in the pathogenesis of synucleinopathies, a group of neurodegenerative diseases including Parkinson disease (PD), dementia with Lewy bodies (DLB), diffuse Lewy body disease (DLBD) and multiple system atrophy (MSA). The common feature of these diseases is a pathological deposition of protein aggregates, known as Lewy bodies (LBs) in the central nervous system. The major component of these aggregates is α-synuclein, a natively unfolded protein, which may undergo dramatic structural changes resulting in the formation of β-sheet rich assemblies. In vitro studies have shown that recombinant α-synuclein protein may polymerize into amyloidogenic fibrils resembling those found in LBs. These aggregates may be uptaken and propagated between cells in a prion-like manner. Here we present the mechanisms and kinetics of α-synuclein aggregation in vitro, as well as crucial factors affecting this process. We also describe how PD-linked α-synuclein mutations and some exogenous factors modulate in vitro aggregation. Furthermore, we present a current knowledge on the mechanisms by which extracellular aggregates may be internalized and propagated between cells, as well as the mechanisms of their toxicity.
ETB receptor involvement in stimulatory and neurotoxic action of endothelin on dopamine neurones (1994)

We examined the role of endothelin (ET) receptor subtypes in mediating the transient and sustained release of dopamine (DA) evoked by ETs and ET-1-induced dopaminergic dysfunction in rat striatal slices. Both phases of the release of DA evoked by ET-1 and ET-3 were inhibited by RES-701-1 (ETB antagonist) but not BQ-123 (ETA antagonist). The high K(+)-evoked DA release from slices remained impaired following a brief exposure to ET-1, under conditions of hypoxia/hypoglycaemia. RES-701-1 but not BQ-123 led to a recovery from ET-1-induced striatal dysfunction. Therefore, ETB receptors are involved in the stimulatory and neurotoxic actions of ETs on the striatal dopaminergic system.
Late-Breaking Abstracts of the 2017 International Headache Congress (2017)

To assess the awareness of migraine (M) and previous diagnostic and therapeutic paths in naif migraineurs visited by a headache specialists in several neo-latin coutries.
사치론을 통해 본 전한 사대부들의 이풍역속 (2003)

Public morals mean unique civil order, social moral fiber, and cultural tradition as well as surface and visible things like the product of the local, a dialect, and music. The ancient Chinese considered public morals as the people`s total reaction to the statesmen political intention, and thought they could achieve their political purpose. That’s why Yi-feng-yi-su(移風易俗) that changes the public morals means the key conception from which we can grasp their value system, and their world view as well as the political purpose and ideal of the statesman at that time. This article is prepared to confirm the political ideal of Shi-da-fu(士大夫) in the Han Dunasty(漢代) through the concept of Yi-feng-yi-su(移風易俗). The objection of criticism for extravagance raised from within Shi-da-fu(士大夫) in the early Han Dynasty was to construct specific public morals. Representatively the extravagances criticized by Liu-jia(陸賈), Jia-yi(賈誼). Wen-xue(文學) in the time of Wu-di(??帝) and the Confucian bureaucracy in the time of Xuan-di (宣帝) were not about the material but about the specific political situation. Though they were a little different from each other, they all blocked the entry and participation of the Confucians in politics, and hindered the autonomy of the Confucian bureaucracy. So Yi-feng-yi-su(移風易俗) without extravagance Shi-da-fu(士大夫) thought was the status that guaranteed the entry and participation of the Confucians in politics and assured the autonomy of them. Therefore it was regarded as Yi-feng-yi-su(移風易俗) in the time of Wen-di(文帝) to establish the ruling order by Huan-lao-shu(黃老術) supporting the reduction of emperor`s power. But it was considered as Yi-feng-yi-su(移風易俗) to acquire the political rights the Confucians in the time of Wu-di (??帝) when readers started to appear in the provinces, and to obtain the identity of provincial rule in the time of Xuan-di (宣帝) when Hao-zu(??族) of the provinces started to be the regional official. And lastly, it was understood as Yi-feng-yi-su(移風易俗) to secure the absoluteness of Confucianism in the time of Yuan-di(元帝) After all, Shi-da-fu(士大夫) in the Han Dynasty intended to make the Confucianism as public morals. This is because Confucianism, especially Gona-yang-xue(公羊學) supported the autonomy of Shi-da-fu(士大夫) and had them establish make their own identity against the emperor’s power.
Choosing an Online Payment Service: Google Checkout vs. PayPal (2006)

Choosing an Online Payment System: Google Checkout vs. PayPal is a digital short cut that covers Google's new Google Checkout online payment system. It covers all aspects of using Google Checkout, for both buyers and sellers, and then compares and contrasts Google Checkout with PayPal, the current market-leader in online payments. You will learn which of the two payment systems, Google Checkout or PayPal, should be used, when given a choice. Sellers will learn which payment system is best to use for their online auctions and merchant websites.Table of Contents1. Buying and Selling Electronically: How Online Payment Systems Work: A general discussion on how PayPal, Google Checkout, and similar online payment systems work2. Using Google Checkout: For Buyers: A detailed discussion on how to use Google Checkout to purchase items online3. Using PayPal: For Buyers: A detailed discussion on how to use PayPal to purchase items online4. Buyer's Choice: Google Checkout or PayPal?: A comparison of Google Checkout with PayPal for online purchasers; also covers other payment systems an online shopper might encounter5. Using Google Checkout: For Sellers: A detailed discussion on how to add Google Checkout to your merchant website and use the service to manage customer payments6. Using PayPal: For Sellers: A detailed discussion on how to add PayPal to your merchant website and eBay auctions and use the service to manage customer payments7. Seller's Choice: Google Checkout or PayPal?: A comparison of Google Checkout with PayPal for online sellers; also covers other alternatives, such as Amazon Payments
Isolation and characterization of the proteinase inhibitor-inducing factor from tomato leaves. Identity and activity of poly- and oligogalacturonide fragments. (1984)

Mild acid hydrolysis of a small (Mr = 6 kDa) pectic polysaccharide isolated from tomato leaves, an inducer of the synthesis and accumulation of two proteinase inhibitors in excised tomato plants, yielded a alpha-D-polygalacturonic acid polymer with degree of polymerization = 20 that retained proteinase inhibitor-inducing activity. Enzymic and acid hydrolysis of this polygalacturonan yielded a series of alpha-1,4-D-galacturonic acid oligomers with degrees of polymerization from 2 to 6 which were purified to homogeneity and assayed for proteinase inhibitor-inducing activity in young excised tomato plants. All of the oligomers exhibited activity. The hexagalacturonide possessed the highest activity and the trimer the lowest. The evidence supports a possible role for plant cell wall fragments as systemic messengers that regulate the expression of proteinase inhibitor genes in plant leaves in response to pest attacks.
Ground plane identification using LIDAR in forested environments (2010)

To operate autonomously in forested environments, unmanned ground vehicles (UGVs) must be able to identify the load-bearing surface of the terrain (i.e. the ground). This paper presents a novel two-stage approach for identifying ground points from 3-D point clouds sensed using LIDAR. The first stage, a local height-based filter, discards most of the non-ground points. The second stage, based on a support vector machine (SVM) classifier, operates on a set of geometrically defined features to identify which of the remaining points belong to the ground. Experimental results from two forested environments demonstrate the effectiveness of this approach.