gebhart/patrepeval huggingface dataset:
Intensive enteral feeding in advanced cirrhosis: reversal of malnutrition without precipitation of hepatic encephalopathy. (1992)

Ten children with advanced cirrhosis and malnutrition (less than 90% weight for height) were fed for eight weeks with a nasogastric feed comprising whey protein (enriched with branched chain amino acids), fat as 34% medium chain and 66% long chain triglycerides, and glucose polymer. Six of the children were studied for an eight week control period before feeding. Weight, triceps skinfold thickness, mid-arm circumference, mid-arm muscle area, and fasting plasma ammonia and amino acid concentrations were measured before and after the control period and after the consequent feed period. Results showed that despite high energy and protein intakes the children remained malnourished over the control period. All anthropometric indices improved significantly during the feed period, and no child developed clinical encephalopathy. The feed period was associated with a small, and not clinically significant, increase in the plasma ammonia concentration, but no consistent trend in the plasma amino acid concentrations. Thus, in children with advanced hepatobiliary disease awaiting liver transplantation, enteral feeding improved nutritional status without adverse clinical or biochemical effects.
Bone Formation and Inflammation in Cardiac Valves (2001)

Heterotopic ossification consisting of mature lamellar bone formation and active bone remodeling is a relatively common and unexpected finding in end-stage valvular heart disease and may be associated with repair of pathological microfractures in calcified cardiac valves.
Chromophore Photoreduction in Red Fluorescent Proteins Is Responsible for Bleaching and Phototoxicity (2014)

Red fluorescent proteins (RFPs) are indispensable tools for deep-tissue imaging, fluorescence resonance energy transfer applications, and super-resolution microscopy. Using time-resolved optical spectroscopy this study investigated photoinduced dynamics of three RFPs, KillerRed, mRFP, and DsRed. In all three RFPs, a new transient absorption intermediate was observed, which decays on a microsecond-millisecond time scale. This intermediate is characterized by red-shifted absorption at 1.68-1.72 eV (λmax = 720-740 nm). On the basis of electronic structure calculations, experimental evidence, and published literature, the chemical nature of the intermediate is assigned to an unusual open-shell dianionic chromophore (dianion-radical) formed via photoreduction. A doubly charged state that is not stable in the isolated (gas phase) chromophore is stabilized by the electrostatic field of the protein. Mechanistic implications for photobleaching, blinking, and phototoxicity are discussed.
DNA Machines: Bipedal Walker and Stepper (2010)

The assembly of a "bipedal walker" and of a "bipedal stepper" using DNA constructs is described. These DNA machines are activated by H(+)/OH(-) and Hg(2+)/cysteine triggers. The bipedal walker is activated on a DNA template consisting of four nucleic acid footholds. The forward "walking" of the DNA on the template track is activated by Hg(2+) ions and H(+) ions, respectively, using the thymine-Hg(2+)-thymine complex or the i-motif structure as the DNA translocation driving forces. The backward "walking" is activated by OH(-) ions and cysteine, triggers that destroy the i-motif or thymine-Hg(2+)-thymine complexes. Similarly, the "bipedal stepper" is activated on a circular DNA template consisting of four tethered footholds. With the Hg(2+)/cysteine and H(+)/OH(-) triggers, clockwise or anticlockwise stepping is demonstrated. The operation of the DNA machines is followed optically by the appropriate labeling of the walker-foothold components with the respective fluorophores/quenchers units.
Ein breitbandiger Oszillator-Meßplatz in flexibler quasioptischer Technik für den Frequenzbereich 170 GHz bis 260 GHz (1995)

Article Ein breitbandiger Oszillator-Meßplatz in flexibler quasioptischer Technik für den Frequenzbereich 170 GHz bis 260 GHz was published on May 1, 1995 in the journal Frequenz (volume 49, issue 5-6).
Discovery of a B-Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach (2017)

B-cell lymphoma 6 (BCL6) is a transcriptional factor that expresses in lymphocytes and regulates the differentiation and proliferation of lymphocytes. Therefore, BCL6 is a therapeutic target for autoimmune diseases and cancer treatment. This report presents the discovery of BCL6-corepressor interaction inhibitors by using a biophysics-driven fragment-based approach. Using the surface plasmon resonance (SPR)-based fragment screening, we successfully identified fragment 1 (SPR K<sub>D</sub> = 1200 μM, ligand efficiency (LE) = 0.28), a competitive binder to the natural ligand BCoR peptide. Moreover, we elaborated 1 into the more potent compound 7 (SPR K<sub>D</sub> = 0.078 μM, LE = 0.37, cell-free protein-protein interaction (PPI) IC<sub>50</sub> = 0.48 μM (ELISA), cellular PPI IC<sub>50</sub> = 8.6 μM (M2H)) by a structure-based design and structural integration with a second high-throughput screening hit.
Structure and Dynamics of Block Copolymer Colloids (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and Dynamics of Block Copolymer ColloidsBenjamin ChuCite this: Langmuir 1995, 11, 2, 414–421Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/la00002a009https://doi.org/10.1021/la00002a009research-articleACS PublicationsRequest reuse permissionsArticle Views1848Altmetric-Citations369LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Unparalleled Control of Neural Activity Using Orthogonal Pharmacogenetics (2012)

Studying the functional architecture of the brain requires technologies to precisely measure and perturb the activity of specific neural cells and circuits in live animals. Substantial progress has been made in recent years to develop and apply such tools. In particular, technologies that provide precise control of activity in genetically defined populations of neurons have enabled the study of causal relationships between and among neural circuit elements and behavioral outputs. Here, we review an important subset of such technologies, in which neurons are genetically engineered to respond to specific chemical ligands that have no interfering pharmacological effect in the central nervous system. A rapidly expanding set of these "orthogonal pharmacogenetic" tools provides a unique combination of genetic specificity, functional diversity, spatiotemporal precision, and potential for multiplexing. We review the main classes of orthogonal pharmacogenetic technologies, including neuroreceptors to control neuronal excitability, systems to control gene transcription and translation, and general constructs to control protein-protein interactions, enzymatic function, and protein stability. We describe the key performance characteristics informing the use of these technologies in the brain, and potential directions for improvement and expansion of the orthogonal pharmacogenetics toolkit to enable more sophisticated systems neuroscience.
Novel porcupine (PORCN) inhibitor RXC004: Evaluation in models of RNF43 loss of function cancers. (2017)

e14094 Background: Wnt signalling initiates oncogenic pathways involved in tumour initiation, growth, differentiation and metastasis. 1 Targeting the Wnt pathway is an attractive approach to cancer treatment. Porcupine (PORCN) is a membrane-bound O-acyltransferase dedicated to the palmitoylation of Wnt ligands, an essential step in the processing of Wnt into active ligands. 2 A PORCN inhibitor may benefit patients with cancers in which Wnt signalling is implicated. It has been shown that PORCN inhibition is efficacious in cell lines with upstream mutations in this pathway, eg RNF43 loss of function. 3 Methods: Analysis of TCGA data was carried out to identify cancer types harbouring RNF43 mutations. 4 Redx PORCN inhibitor RXC004 was evaluated in vitro for Wnt pathway inhibition and anti-proliferative effects using assays previously described for early lead compounds. 5 Anti-tumour effects of RXC004 were evaluated using a pancreatic CAPAN-2 xenograft in SCID Bg. mice and a gastric PDX model in nu/nu mice. Both models have RNF43 loss of function mutations. Results: TCGA data revealed that both gastric cancer and pancreatic cancer exhibit mutations in the RNF43 gene (18% and 4% respectively), 4 expected to result in loss of function. RXC004 showed activity in preclinical models of cancers with this genetic background. RXC004 significantly inhibited tumour growth in a CAPAN-2 pancreatic cancer xenograft and in a gastric cancer PDX model when dosed orally once or twice daily. Conclusions: Taken together, these data indicate that RXC004 is a potent inhibitor of tumour growth in RNF43 loss of function preclinical cancer models. RXC004 will be evaluated in a first in human Phase 1 study in 2017. Phase 1a aims are to characterise the safety profile and PK/PD relationship in cancer patients and establish a Phase 1b dose. The efficacy of RXC004 in gastric and pancreatic cancer patients prospectively selected for RNF43 loss of function mutations will be the focus of Phase 1b expansion groups. 1 . Nat. Rev. Cancer, 2013, 13 (1): 11-26.2. J. Biol. Chem., 2012, 287 (27): 23246-23254. 3. PNAS, 2013, 110 (31): 12649-12654 4. Sci. Signal, 2013, 269 (6): 1-34; Cancer Discov., 2012, 2 (5): 401-404 5. AACR Annual Meeting, 2015, 75 (15): abs. 5071.
On video formats and coding efficiency (2001)

This paper examines the efficiency of MPEG-2 coding for interlaced and progressive video, and compares de-interlacing and picture rate up-conversion before and after coding. We found receiver side de-interlacing and picture rate up-conversion (i.e. after coding) to give better image quality at a given data rate. In contrast with some other publications, we found interlaced video coding to be better than progressive video coding for many relevant sequences, even when comparing the results on a progressive display.
Understanding Material Characteristics through Signature Traits from Helium Pycnometry (2019)

Although helium pycnometry is generally the method of choice for skeletal density measurements of porous materials, few studies have provided a wide range of case studies that demonstrate how to best interpret raw data and perform measurements using it. The examination of several different classes of materials yielded signature traits from helium pycnometry data that are highlighted. Experimental parameters important in obtaining the most precise and accurate value of skeletal density from the helium pycnometer are as high as possible percent fill volume and good thermostability. The degree of sample activation is demonstrated to affect the measured skeletal density of porous zeolitic, carbon, and hybrid inorganic-organic materials. In the presence of a significant amount of physisorbed contaminants (water vapor, atmospheric gases, residual solvents, etc.), which was the case for ZSM-5, MIL-53, and F400, but not ZIF-8, the skeletal density tended to be overestimated in the low percent volume region. In addition, the kinetic data (i.e., skeletal density vs measurement cycle) reveals distinctive traits for a properly activated vs a nonactivated sample for all examined samples: activated samples with a significant amount of mass loss show a curved down plot that eventually reaches the equilibrium value, whereas nonactivated, nonporous, or extremely hydrophobic samples exhibit a flat line. This work illustrates how helium pycnometry can provide information about the structure of a material, and that, conversely, when the structure of the material and its percent mass loss after activation (amount of physisorbed contaminants) are known, the behavior of activated and nonactivated samples in terms of skeletal density, percent fill volume, and measurement cycle can be predicted.
Applications of combinatorial designs in computer science (1989)

The theory of combinatorial designs has been used in widely different areas of computation concerned with the design and analysis of both algorithms and hardware. Combinatorial designs capture a subtle balancing property that is inherent in many difficult problems and hence can provide a sophisticated tool for addressing these problems. The role of combinatorial designs in solving many problems that are basic to the field of computing is explored in this paper. Case studies of many applications of designs to computation are given; these constitute a first survey, which provides a representative sample of uses of designs. More importantly, they suggest paradigms in which designs can be used profitably in algorithm design and analysis.
Vardenafil: efficacy, tolerability and future directions (2009)

Vardenafil is a short-acting PDE5 inhibitor used in the treatment of male erectile dysfunction. It is the most potent and specific of the three commercially available PDE5 inhbitors, which may decrease incidence of side effects, although this has not been demonstrated clinically. Although its efficacy in the treatment of erectile dysfunction has been demonstrated in several studies, recent and continuing studies have shown vardenafil's promise as an effective agent in penile rehabilitation, decreasing lower urinary tract symptoms resulting from benign prostatic hyperplasia and management of pulmonary hypertension.
Insights into the mechanisms of fault-related folding provided by volumetric structural restorations using spatially varying mechanical constraints (2009)

We use a new, mechanically based volumetric structural restoration tool to investigate the mechanics of fault-related folding using natural examples imaged in three-dimensional (3-D) seismic data. The restoration technique is based on a finite element approach that simultaneously restores folding and faulting while allowing rock properties to spatially vary during restoration. We apply these techniques to two types of structures, detachment and shear fault-bend folds, where mechanical layering is a significant factor in their development. Our examples include a detachment anticline from the Caspian Sea and a shear fault-bend fold from the deep-water Niger Delta, both of which contain syntectonic growth horizons that help to constrain the restorations. Restorations of the detachment fold most closely match displacement fields specified in the kinematic forward models when materials are defined as incompressible and rigid, yet the variation of mechanical strength in restorations is perhaps more compatible with the growth of natural structures as recorded by syntectonic growth strata. This analysis shows that the restorations of the detachment fold favor a combination of both kink-band migration and limb rotation folding mechanisms. Numerical simulations of the growth shear fault-bend fold also closely match the displacement field prescribed by the kinematics of shear fault-bend fold models when weak basal units and bedding-plane slip surfaces, enabling flexural slip, are incorporated in the model. The results demonstrate that these techniques can be used to provide full 3-D restorations that closely match established two-dimensional kinematic theories, yet allow constraint of 3-D displacement fields and strain patterns in complex structures.
Increased vagal tone accounts for the observed immune paralysis in patients with traumatic brain injury (2008)

Traumatic brain injury (TBI) is a leading cause of death and disability, especially in the younger population. In the acute phase after TBI, patients are more vulnerable to infection, associated with a decreased immune response in vitro. The cause of this immune paralysis is poorly understood. Apart from other neurologic dysfunction, TBI also results in an increase in vagal activity. Recently, the vagus nerve has been demonstrated to exert an anti-inflammatory effect, termed the cholinergic anti-inflammatory pathway. The anti-inflammatory effects of the vagus nerve are mediated by the alpha 7 nicotinic acetylcholine receptor present on macrophages and other cytokine-producing cells. From these observations, we hypothesize that the immune paralysis observed in patients with TBI may, at least in part, result from augmented vagal activity and subsequent sustained effects of the cholinergic anti-inflammatory pathway. This pathway may counteract systemic proinflammation caused by the release of endogenous compounds termed alarmins as a result of tissue trauma. However, sustained activity of this pathway may severely impair the body's ability to combat infection. Since the cholinergic anti-inflammatory pathway can be pharmacologically modulated in humans, it could represent a novel approach to prevent infections in patients with TBI.
Manufacturing Concepts for Stretchable Electronic Systems (2008)

Assembly of electronic components on rigid and/or flexible printed circuit boards is today the customary way to fabricate electronic systems in stationary, mobile and automotive applications. On the other hand, many of the demands from emerging application fields like wearable and textile electronics cannot be met if with standard technologies. These fields have therefore become mayor drivers for the development of novel technologies. Among these 'stretchable electronics' have attracted much attention recently. Especially for textile applications the potential of the electronic system to comply with the body shape and movement will considerably improve the user comfort. This paper will present a cost effective technology for the realization of stretchable systems by common printed circuit board techniques with polyurethane as a stretchable matrix material. Mastering of the adhesion between materials and the transitions region from stretchable to non-stretchable parts of the system are crucial for the mechanical performance and robustness. Technical approaches and the obtained results to tackle these issues will be presented. The described process technology bears the potential for large scale roll to roll processing. Reliability aspects for stretchable electronic systems are so far not standardized and will be discussed briefly. Electrical and mechanical functionality of test vehicles subjected to multiple stretch and mild washing cycles will be presented. A functional electronic demonstrator with embedded passives, a micro controller, and LEDs which was realized with this technology will be shown.
Sensor Fusion for Accurate Computation of Yaw Rate and Absolute Velocity (2001)

<div class="htmlview paragraph">In the presented sensor fusion approach, centralized filtering of related sensor signals is used to improve and correct low price sensor measurements. From this, we compute high-quality state information as drift-free yaw rate and exact velocity (accounting for unknown tire radius and slipping wheels on 4WD vehicles). The basic tool here is a Kalman filter supported by change detection for sensor diagnosis. Results and experience of real-time implementations are presented.</div>
A novel degradative pathway of 2-nitrobenzoate via 3-hydroxyanthranilate in<i>Pseudomonas fluorescens</i>strain KU-7 (2000)

A bacterial strain KU-7, identified as a Pseudomonas fluorescens by 16S rDNA sequencing, was one of the 12 new isolates that are able to grow on 2-nitrobenzoate as a sole source of carbon, nitrogen, and energy. Resting cells of KU-7 were found to accumulate ammonia in the medium indicating that degradation of 2-NBA proceeds through a reductive route. Metabolite analyses by thin layer chromatography and high pressure liquid chromatography indicated that 3-hydroxyanthranilate is an intermediate of 2-nitrobenzoate metabolism in KU-7 cells. This offers an alternative route to 2-nitrobenzoate metabolism since anthranilate (2-aminobenzoate) or catechol were detected as intermediates in other bacteria. Crude extracts of KU-7 cells converted 2-nitrobenzoate to 3-hydroxyanthranilate with oxidation of 2 mol of NADPH. Ring cleavage of 3-hydroxyanthranilate produced a transient yellow product, identified as 2-amino-3-carboxymuconic 6-semialdehyde, that has a maximum absorbance at 360 nm. The initial enzymes of the 2-nitrobenzoate degradation pathway were found to be inducible since succinate-grown cells produced very low enzyme activities. A pathway for 2-nitrobenzoate degradation in KU-7 was proposed.
Variable Frequency Transformer Electromagnetic Design Concept (2007)

Variable frequency transformer (VFT) is a controllable bi-directional transmission device that can transfer power between asynchronous networks. The construction of VFT is similar to conventional asynchronous machines. Electrical power is exchanged between the two networks by magnetic coupling through the air gap of the VFT. This paper gives an overview of the electromagnetic design concept of the VFT.
Enzyme-Activated Gd3+ Magnetic Resonance Imaging Contrast Agents with a Prominent Receptor-Induced Magnetization Enhancement (2001)

Clinically relevant relaxivity enhancement of a magnetic resonance imaging (MRI) contrast agent has been achieved by using prodrug Gd<sup>3+</sup> complexes (see picture, DTPA=diethylenetriaminepentaaceto). Enzymatic cleavage of lysine residues from the prodrug exposes a group that has a high affinity to human serum albumin and promotes enhanced relaxivity, thus enabling the detection of targets at submicromolar concentrations.
Orchestrated SDN-based VDC provisioning over multi-technology optical data centre networks (2017)

In this paper, we describe some scenarios and technologies that have been proposed to cope with the requirements of current and next generation data centre infrastructure. In particular, we discuss the extensions that have been implemented at both orchestration and control levels to efficiently manage the data centres resources. We put the focus on the integration between the Orchestrator and the SDN Controller by describing the communication interfaces and their interaction to provision optimized Virtual Data Centres (VDC) instances over novel data centre infrastructure, with special mention to the different solutions adopted to manage multiple optical technologies at the data plane.
Finite element modeling of single shear fastener joint specimens: a study of clamp-up, friction and plasticity effects (2011)

Thesis (M.S.)--Wichita State University, College of Engineering, Dept. of Aerospace Engineering.