gebhart/patrepeval huggingface dataset:
Wireless Sensor Networks for Cost-Efficient Residential Energy Management in the Smart Grid (2011)

Wireless sensor networks (WSNs) will play a key role in the extension of the smart grid towards residential premises, and enable various demand and energy management applications. Efficient demand-supply balance and reducing electricity expenses and carbon emissions will be the immediate benefits of these applications. In this paper, we evaluate the performance of an in-home energy management (iHEM) application. The performance of iHEM is compared with an optimization-based residential energy management (OREM) scheme whose objective is to minimize the energy expenses of the consumers. We show that iHEM decreases energy expenses, reduces the contribution of the consumers to the peak load, reduces the carbon emissions of the household, and its savings are close to OREM. On the other hand, iHEM application is more flexible as it allows communication between the controller and the consumer utilizing the wireless sensor home area network (WSHAN). We evaluate the performance of iHEM under the presence of local energy generation capability, prioritized appliances, and for real-time pricing. We show that iHEM reduces the expenses of the consumers for each case. Furthermore, we show that packet delivery ratio, delay, and jitter of the WSHAN improve as the packet size of the monitoring applications, that also utilize the WSHAN, decreases.
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. (1995)

The mechanism of mitogen-activated protein (MAP) kinase activation by pertussis toxin-sensitive Gi-coupled receptors is known to involve the beta gamma subunits of heterotrimeric G proteins (G beta gamma), p21ras activation, and an as-yet-unidentified tyrosine kinase. To investigate the mechanism of G beta gamma-stimulated p21ras activation, G beta gamma-mediated tyrosine phosphorylation was examined by overexpressing G beta gamma or alpha 2-C10 adrenergic receptors (ARs) that couple to Gi in COS-7 cells. Immunoprecipitation of phosphotyrosine-containing proteins revealed a 2- to 3-fold increase in the phosphorylation of two proteins of approximately 50 kDa (designated as p52) in G beta gamma-transfected cells or in alpha 2-C10 AR-transfected cells stimulated with the agonist UK-14304. The latter response was pertussis toxin sensitive. These proteins (p52) were also specifically immunoprecipitated with anti-Shc antibodies and comigrated with two Shc proteins, 46 and 52 kDa. The G beta gamma- or alpha 2-C10 AR-stimulated p52 (Shc) phosphorylation was inhibited by coexpression of the carboxyl terminus of beta-adrenergic receptor kinase (a G beta gamma-binding pleckstrin homology domain peptide) or by the tyrosine kinase inhibitors genistein and herbimycin A, but not by a dominant negative mutant of p21ras. Worthmannin, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K) inhibited phosphorylation of p52 (Shc), implying involvement of PI3K. These results suggest that G beta gamma-stimulated Shc phosphorylation represents an early step in the pathway leading to p21ras activation, similar to the mechanism utilized by growth factor tyrosine kinase receptors.
The IN-VIVO Occurrence of Z DNA (1983)

The energetics of the B-Z transition of two different types of cloned alternating purine/pyrimidine DNA sequences have been analysed by a two dimensional electrophoretic technique. Since the transition between right handed and left handed forms of these polymers is detected by alterations of electrophoretic mobilities of topoisomers of the plasmid DNA molecules, the method is not dependent on Z-DNA binding ligands. The measurements reflect intrinsic properties of the DNA unperturbed by the free energy of binding such a ligand. Direct evidence from the analysis of topoisomer distributions is presented which shows that d(GC)n.d(GC)n sequence elements within an E. coli plasmid will adopt a Z conformation in-vivo under conditions of blocked protein synthesis. Evidence for the in-vivo occurrence of Z-DNA was not detected in plasmid DNA isolated from bacterial cells growing in the absence of protein synthesis inhibitors. A model is proposed for a function for the B-Z transition in ensuring the correct pairing of homologous chromosomes during meiosis.
Influence of Alcohol on the Release of Tramadol from 24-h Controlled-Release Formulations During In Vitro Dissolution Experiments (2008)

Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram ER tablets and T-long capsules was significantly increased in the presence of ethanol. Conversely, a decrease in the rate of tramadol release was seen from Tridural extended-release tablets in the presence of alcohol.
Preparation of a single atom in an optical microtrap (2013)

We investigate the use of light assisted collisions for the deterministic preparation of individual atoms in a microtrap. Blue detuned light is used in order to ensure that only one of the collision partners is lost from the trap. We obtain a 91% loading efficiency of single 85Rb atoms. This can be achieved within a total preparation time of 542 ms. A numerical model of the process quantitatively agrees with the experiment giving an in-depth understanding of the dynamics of the process and allowing us to identify the factors that still limit the loading efficiency. The fast loading time in combination with the high efficiency may be sufficient for loading quantum registers at the size required for competitive quantum computing.
Waalbot: An Agile Small-Scale Wall Climbing Robot Utilizing Pressure Sensitive Adhesives (2006)

This paper proposes a small-scale agile wall climbing robot able to navigate on smooth surfaces of any orientation, including vertical and inverted surfaces, which uses adhesive elastomer materials for attachment. Using two actuated legs with rotary motion and two passive revolute joints at each foot the robot can climb and steer in any orientation. Due to its compact design, a high degree of miniaturization is possible. It has onboard power, sensing, computing, and wireless communication which allow for semi-autonomous operation. Various aspects of a functioning prototype design and performance are discussed in detail, including leg and feet design and gait control. The current prototype can climb 90deg slopes at a speed of 6 cm/s and steer to any angle. This robot is intended for inspection and surveillance applications and, ultimately, space missions
Synthesis of Novel Fatty Acid Derivatives of Etidronic Acid (2005)

Synthesis of (1-acyloxyethylidene)-1,1-bisphosphonic acids, where the acyl group is decanoyl (1a), lauroyl (1b), palmitoyl (1c), stearoyl (1d) or oleoyl (1e) have been described. Preparation of (1-oleoyloxyethylidene)-1,1-bisphosphonic acid tetramethyl ester (2) and its P,P′-dimethyl ester (disodium salt 3 and acid form 4) in multigram scale has also been reported. Solubility of 1e in organic solvents and water was tested.
Characterization of Mutations in Barley fch2 Encoding Chlorophyllide a Oxygenase (2012)

The barley (Hordeum vulgare L.) mutants fch2 and clo-f2 comprise an allelic group of 14 Chl b-deficient lines. The genetic map position of fch2 corresponds to the physical map position of the gene encoding chlorophyllide a oxygenase. This enzyme converts chlorophyllide a to chlorophyllide b and it is essential for Chl b biosynthesis. The fch2 and clo-f2 barley lines were shown to be mutated in the gene for chlorophyllide a oxygenase. A five-base insertion was found in fch2 and base deletions in clo-f2.101, clo-f2.105, clo-f2.2800 and clo-f2.3613. In clo-f2.105 and clo-f2.108, nonsense base exchanges were discovered. All of these mutations led to a premature stop of translation and none of the mutants formed Chl b. The mutant clo-f2.2807 was transcript deficient and formed no Chl b. Missense mutations in clo-f2.102 (leading to the amino acid exchange D495N) and clo-f2.103 (G280D) resulted in a total lack of Chl b, whereas in the missense mutants clo-f2.107 (P419L), clo-f2.109 (A94T), clo-f2.122 (C320Y), clo-f2.123 (A94T), clo-f2.133 (A376V) and clo-f2.181 (L373F) intermediate contents of Chl b were determined. The missense mutations affect conserved residues, and their effect on chlorophyllide a oxygenase is discussed. The mutations in clo-f2.102, clo-f2.103, clo-f2.133 and clo-f2.181 may influence electron transfer as illustrated in the active site of a structural model protein. The changes in clo-f2.107, clo-f2.109, clo-f2.122 and clo-f2.123 may lead to Chlb deficiency by interfering with the regulation of chlorophyllide a oxygenase. The correlation of mutations and phenotypes strongly supports that the barley locus fch2 encodes chlorophyllide a oxygenase.
Estrogen regulation of proto-oncogenes coding for nuclear proteins. (1993)

Estrogen hormones are known to exert a complex influence on development and function of the female reproductive organs of vertebrates by regulating cell growth and differentiation, as well as to be implicated in oncogenesis and maintenance of tumor growth. Estrogen acts on cells via interaction with an intracellular receptor, which, like all receptors for steroid hormones, is a trans-acting transcription enhancer factor activated by the cognate ligand and capable of binding to specific, cis-acting enhancer elements usually located within the 5'-flanking regions of target genes. Additionally, estrogen regulates gene expression by influencing mRNA stability or via interaction of the estrogen receptor with transcription regulatory factors. This article reviews data indicating that estrogen directly activates (primary activation) expression of proto-oncogenes codifying for nuclear proteins that, in turn, are responsible for indirect (secondary) activation of other genes. This cascade mechanism of gene activation is likely to progress for several more steps and allows us to envisage how estrogen can direct a complex task such as cell reproduction. Among proto-oncogenes codifying for nuclear proteins, we focus on fos, jun, myc, and related genes. The mechanisms of regulation of these genes by estrogen, including regulation of transcription, messenger RNA stabilization, and protein-protein interaction, are reviewed.
Ophthalmic Manifestations of HIV: An Update (2001)

A variety of ocular disease processes have been identified in HIV-antibody positive persons, especially in people with AIDS. The most common sight-threatening disease in this population is cytomegalovirus (CMV) retinitis. Effective therapies are available to treat CMV retinitis. However, such therapies carry potentially challenging toxicities. Highly active antiretroviral therapy (HAART) has improved immune system functioning in many of its adherents, decreasing the incidence and improving the clinical course of CMV retinitis. However, a recent phenomenon associated with HAART, immune recovery uveitis (IRU), has been noted with additional, often problematic ocular manifestations in many persons with CMV retinitis. Periodic ophthalmic examination is prudent for all persons with HIV and especially for people with AIDS.
Frequent and early loss of chromosome 9p in cutaneous melanoma (1993)

Fountain, J. W.; Graw, S. L.; Kao, W. H.; Dracopoli, N. C.; Housman, D. E. Author Information
Simplest Cases (1965)

Now let us see how, on first principles, we can differentiate some simple algebraical expression.
Towards Trust-Aware Resource Management in Grid Computing Systems (2003)

Resource management is a central part of a Grid computing system. In a large-scale wide-area system such as the Grid, security is a prime concern. One approach is to be conservative and implement techniques such as sandboxing, encryption, and other access control mechanisms on all elements of the Grid. However, the overhead caused by such a design may negate the advantages of Grid computing. This study examines the integration of the notion of "trust" into resource management such that the allocation process is aware of the security implications. We present a formal definition of trust and discuss a model for incorporating trust into Grid systems. As an example application of the ideas proposed, a resource management algorithm that incorporates trust is presented. The performance of the algorithm is examined via simulations.
Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward (2020)

Peptide receptor radionuclide therapy (PRRT) is a highly effective anti-cancer treatment modality for patients with non-resectable, metastasized neuroendocrine tumors (NETs). During PRRT, specific receptors that are overexpressed on the cancer cells are targeted with a peptide labeled with a DNA-damaging radionuclide. Even though PRRT is a powerful treatment for metastasized NET patients, the majority still cannot be cured at this stage of the disease. Hence, many investigators focus on improving the therapeutic efficacy of this therapy. Improving PRRT can, for example, be achieved by using other radionuclides with different physical properties, by combining PRRT with radiosensitizing agents or by radiolabeling peptides with different characteristics. However, due to lack of extensive knowledge of radiobiological responses of cancer cells to PRRT, biological parameters that influence absorbed dose or that might even elicit insensitivity to therapy remain elusive and the context in which these improvements will be successful warrants further investigation. In this review, we will discuss the development of PRRT, its clinical merits in current treatment and future perspectives. We will highlight different radionuclides and their benefits and pitfalls, as well as different peptide-conjugates that hold these radionuclides. We will zoom in on the latest developments regarding combinatorial treatments and how investigators from different disciplines such as dosimetry and radiobiology are now joining forces to improve PRRT for NETs.
pMPES: A Modular Peptide Expression System for the Delivery of Antimicrobial Peptides to the Site of Gastrointestinal Infections Using Probiotics (2016)

Antimicrobial peptides are a promising alternative to traditional antibiotics, but their utility is limited by high production costs and poor bioavailability proﬁles. Bacterial production and delivery of antimicrobial peptides (AMPs) directly at the site of infection may offer a path for effective therapeutic application. In this study, we have developed a vector that can be used for the production and secretion of seven antimicrobial peptides from both Escherichia coli MC1061 F' and probiotic E.coli Nissle 1917. The vector pMPES (Modular Peptide Expression System) employs the Microcin V (MccV) secretion system and a powerful synthetic promoter to drive AMP production. Herein, we demonstrate the capacity of pMPES to produce inhibitory levels of MccV, Microcin L (MccL), Microcin N (McnN), Enterocin A (EntA), Enterocin P (EntP), Hiracin JM79 (HirJM79) and Enterocin B (EntB). To our knowledge, this is the ﬁrst demonstration of such a broadly-applicable secretion system for AMP production. This type of modular expression system could expedite the development of sorely needed antimicrobial technologies.
Effect of IL‐2‐Bax, a novel interleukin‐2‐receptor‐targeted chimeric protein, on bleomycin lung injury<sup>1</sup> (2005)

The role of lymphocytes in the pathogenesis of lung fibrosis is not clear, but the weight of the evidence supports a pro-fibrotic effect for lymphocytes. The high-affinity interleukin-2 receptor (haIL-2R) is expressed on activated, but not quiescent, T lymphocytes. This selective expression of haIL-2R provides the basis for therapeutic strategies that target IL-2R-expressing cells. We hypothesized that elimination of activated lymphocytes by IL-2R-targeted chimeric proteins might ameliorate lung fibrosis. We investigated the effects of IL-2-Bax, a novel apoptosis-inducing IL-2R-targeted chimeric protein, on bleomycin-induced lung injury in mice. Treatment groups included (i) a single intratracheal instillation of bleomycin and twice-daily intraperitoneal injections of IL-2-Bax; (ii) intratracheal bleomycin and intraperitoneal IL-2-PE66(4Glu), an older-generation chimeric protein; (iii) intratracheal bleomycin/intraperitoneal PBS; (iv) intratracheal saline/intraperitoneal PBS. Lung injury was evaluated 14 days after intratracheal instillation by cell count in bronchoalveolar lavage (BAL) fluid, semi-quantitative and quantitative histomorphological measurements and by biochemical analysis of lung hydroxyproline. Bleomycin induced a BAL lymphocytosis that was significantly attenuated by IL-2-Bax and IL-2-PE66(4Glu). However, morphometric parameters and lung hydroxyproline were unaffected by the chimeric proteins. These results show that IL-2-Bax reduces the lymphocytic infiltration of the lungs in response to bleomycin, but this effect is not accompanied by a decrease in lung fibrosis.
Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells (2008)

Leukotrienes (LTs) are powerful proinflammatory lipid mediators that may play a central role in cardiovascular diseases, including arteriosclerosis, myocardial infarction, and stroke. Owing to restricted expression of 5-lipoxygenase (5-LO), the enzyme required for their synthesis, LTs are almost exclusively produced by myeloid cells. Here, we report that human cytomegalovirus (HCMV) infection of human vascular smooth muscle cells (SMCs) increases 5-LO mRNA levels by up to 170-fold in a dose- and time-dependent manner. Infected cells expressed 5-LO protein, as shown by immunohistochemistry, enabling them to synthesize bioactive LTB(4). HCMV-infected vascular SMCs expressing 5-LO protein were readily detected in tissue samples from CMV-infected patients with inflammatory bowel disease or AIDS. Thus, pathogen-induced LT production in HCMV-infected tissues may contribute to local inflammation, consistent with the ability of HCMV to control cellular and immunological functions. HCMV-induced LT biosynthesis in SMCs offers a molecular mechanism to explain HCMV-induced pathogenesis in inflammatory diseases.
Nanostructured metal oxide/conjugated polymer hybrid solar cells by low temperature solution processes (2007)

In this article, we have proposed a nanostructured photovoltaic device based on the ZnO nanostructures/poly(3-hexylthiophene)(P3HT):TiO2 nanorod hybrid by solution processes at low temperature. An array of ZnO nanorods with a larger size of ∼50 nm in diameter and ∼180 nm in length are grown to provide direct pathways for efficient charge collection. TiO2 nanorods with a size of ∼5 nm in diameter and ∼20–30 nm in length are incorporated into polymers to facilitate charge separation and transport by providing an increased interfacial area and a more effective transport pathway. The device performance with the inclusion of TiO2 nanorods exhibits a seven times increase in the short circuit current with respect to that without TiO2 nanorods. The device performance can be further enhanced after completely removing the residual surfactant on the TiO2 nanorods using the ligand exchange method, giving a short circuit current density of 2.67 mA cm−2 and a power conversion efficiency of 0.59% under Air Mass 1.5 (100 mW cm−2) illumination.
83 • El diagnóstico integral en la rehabilitación oral (2019)

Para realizar una rehabilitación integral del Sistema Estomatognático (SE) se toma al diagnóstico como punto de partida y condicionante de los tratamientos. Llevar a cabo la misma supone una secuencia de trabajo ordenada e interdisciplinaria que permita tener en cuenta todos los componentes del sistema y no alterar el organigrama de trabajo. A continuación se propone revisar los conceptos actuales para arribar a un correcto diagnóstico del SE.
9.8 Receiver with integrated magnetic-free N-path-filter-based non-reciprocal circulator and baseband self-interference cancellation for full-duplex wireless (2016)

Full-duplex (FD) is an emergent wireless communication paradigm where the transmitter (TX) and the receiver (RX) operate at the same time and at the same frequency. The fundamental challenge with FD is the tremendous amount of TX self-interference (SI) at the RX. Low-power applications relax FD system requirements [1], but an FD system with -6dBm transmit power, 10MHz signal bandwidth and 12dB NF budget still requires 86dB of SI suppression to reach the -92dBm noise floor. Recent research has focused on techniques for integrated self-interference cancellation (SIC) in FD receivers [1-3]. Open challenges include achieving the challenging levels of SIC through multi-domain cancellation, and low-loss shared-antenna (ANT) interfaces with high TX-to-RX isolation. Sharedantenna interfaces enable compact form factor, translate easily to MIMO, and ease system design through channel reciprocity.
Enhancement of <i>sp</i>3/<i>sp</i>2 ratio in plasma deposited amorphous hydrogenated carbon films by the addition of ammonia (1992)

Ammonia (NH3) and nitrogen (N2) were added to the hydrocarbon precursor 1,3 butadiene (C4H6) during rf plasma deposition of hydrogenated amorphous carbon (a:C-H) films. The effect of the additives on the film characteristics was determined by IR spectroscopy, solid state 13C cross polarization magic angle spinning nuclear magnetic resonance, and etching in an oxygen plasma. Nitrogen incorporation in the films was studied by Auger electron spectroscopy. Compared to films deposited in the presence of N2, the films deposited from a C4H6/NH3 plasma had an sp3/sp2 ratio that was 40% higher. IR spectra of the films confirm the higher sp3/sp2 ratio. Also, the films deposited from C4H6/NH3 mixtures exhibited lower etch rates in an oxygen plasma. The larger sp3/sp2 ratio is due to the higher concentration of NHx and H species in a C4H6/NH3 plasma.
Soft Word Sense Disambiguation (2004)

Word sense disambiguation is a core problem in many tasks related to language processing. In this paper, we introduce the notion of soft word sense disambiguation which states that given a word, the sense disambiguation system should not commit to a particular sense, but rather, to a set of senses which are not necessarily orthogonal or mutually exclusive. The senses of a word are expressed by its WordNet synsets, arranged according to their relevance. The relevance of these senses are probabilistically determined through a Bayesian Belief Network. The main contribution of the work is a completely probabilistic framework for word-sense disambiguation with a semi-supervised learning technique utilising WordNet. WordNet can be customized to a domain using corpora from that domain. This idea applied to question answering has been evaluated on TREC data and the results are promising.
A general purpose 1024-stage electronically programmable transversal filter (1980)

The architecture, design, and performance of a filter implemented in CCD/NMOS technology is described. The device features programmability of the reference signal, the filter length, and weighting coefficient resolution. Off-chip circuitry is minimized by incorporating both analog and digital support circuitry, such as clock logic, drivers, amplifiers, and microprocessor interface circuitry on chip. This results in a monolithic analog signal processing system that has the flexibility to be operated in nine programmable configurations, from 1024 stages by 1 bit, to 128 stages by 8 bits. The versatility of the device makes it suitable for a wide range of applications, from matched filtering with chirp signals and very long binary sequences, to image correlation and chirp signals and very long binary sequences, to image correlation and programmable filtering.