gebhart/patrepeval huggingface dataset:
Degradation of Cytochrome Oxidase Subunits in Mutants of Yeast Lacking Cytochrome c and Suppression of the Degradation by Mutation of yme1 (1995)

We have confirmed by spectral analysis that cytochrome oxidase is not present in strains of the yeast Saccharomyces cerevisiae having a primary deficiency in cytochrome c, and we have demonstrated by immunological procedures that such strains lack the mitochondrially encoded subunits I, II, and III of cytochrome oxidase. Furthermore, pulse-chase experiments demonstrated that subunit II is rapidly degraded in vivo. This degradation can be at least partially suppressed by disruption of the nuclear gene YME1, which encodes a putative ATP-Zn(2+)-dependent protease. We suggest that the cytochrome oxidase subunits are not properly assembled in the absence of cytochrome c, and that Yme1 and possibly other proteases degrade the unassembled mitochondrial-encoded subunits of cytochrome oxidase.
Drift Transport in Al<sub>2</sub>O<sub>3</sub>-Sheathed 3-D Transparent Conducting Oxide Photoanodes Observed in Liquid Electrolyte-Based Dye-Sensitized Solar Cells (2014)

It has long been taken for granted that electron transport in liquid-electrolyte-based dye-sensitized solar cells (DSSCs) undergoes an ambipolar diffusive transport due to the strong coupling between electrons in the photoanode and the nearby mobile cations in liquid electrolyte, which, therefore, screens off any electric field in the photoanodes and consequently eliminates the possibility for drift transport. In this work, we demonstrate the existence of drift transport in liquid electrolyte-based DSSCs using a thin Al2O3-sheathed 3-dimentional (3-D) fluorinated tin oxide (FTO), as photoanodes. The electron diffusion rate in such 3-D TCO based DSSC exhibits a striking enhancement to the value of ∼10–2 cm2/s, about 104 times faster than that of the TiO2 nanoparticle-based DSSCs. The electron diffusion coefficient is independent of the photoelectron density, while intensity modulated photocurrent spectroscopy (IMPS) suggests that the time constants of electron transport exhibit a linear dependence on the bias voltage, a strong indication of drift transport behavior in this 3-D FTO hollow nanobeads-based DSSC, despite the use of liquid I–/I3– electrolyte.
<italic>Why so many people</italic>? Explaining Nonhabitual Transport Overcrowding With Internet Data (2015)

Public transport smartcard data can be used for detection of large crowds. By comparing statistics on habitual behavior (e.g., average by time of day), one can specifically identify nonhabitual crowds, which are often very problematic for transport systems. While habitual overcrowding (e.g., peak hour) is well understood both by traffic managers and travelers, nonhabitual overcrowding hotspots can become even more disruptive and unpleasant because they are generally unexpected. By quickly understanding such cases, a transport manager can react and mitigate transport system disruptions. We propose a probabilistic data analysis model that breaks each nonhabitual overcrowding hotspot into a set of explanatory components. The potential explanatory components are initially retrieved from social networks and special events websites and then processed through text-analysis techniques. Finally, for each such component, the probabilistic model estimates a specific share in the total overcrowding counts. We first validate with synthetic data and then test our model with real data from the public transport system (EZLink) of Singapore, focused on three case study areas. We demonstrate that it is able to generate explanations that are intuitively plausible and consistent both locally (correlation coefficient, i.e., CC, from 85% to 99% for the three areas) and globally (CC from 41.2% to 83.9%). This model is directly applicable to any other domain sensitive to crowd formation due to large social events (e.g., communications, water, energy, waste).
A new CMOS electronically tunable current conveyor and its application to current-mode filters (2006)

In this paper, a new CMOS high-performance electronically tunable second-generation current conveyor (ECCII) is presented. The current gain of the proposed ECCII can be controlled electronically by adjusting the ratio of dc bias currents of the ECCII. The output terminal of the proposed ECCII has high impedance, which enables easy cascadability. Also, as an application, the proposed ECCII is used for realizing a universal current-mode filter. The filter realizes low-pass, bandpass, and high-pass responses simultaneously. The low-pass response is obtained at high impedance output and its gain can be independently tuned by changing the current gain of the relevant CC. SPICE simulation results using TSMC 0.35-/spl mu/m CMOS process model shows excellent performance for the proposed ECCII. The proposed circuit consumes average power of 6.6 mW using /spl plusmn/1.5-V supply voltages.
Pedestrian Detection Using Multi-layer LIDAR (2017)

To avoid the potential risk of collision between pedestrians and egovehicle, we propose a new pedestrian detection algorithm based on multi-layer LIDAR. First, the points are clustered based on point-distance segmentation, and non-pedestrian clusters are eliminated with physical attributes of pedestrian. Then pedestrian probability is calculated using Bayes rules, and non-parametric kernel density likelihood function estimation model is established to estimate the pose of pedestrian. Moreover, linear Kalman filter is utilized to track the pedestrian which improves the detection accuracy at part occlusion situation. The experiment validates that our algorithm can accurately detect pedestrians in front of ego-vehicle, and the recognition results based on the fusion of detection and tracking processes is better than those from single pedestrian attribute detection.
Sodium dodecyl sulfate‐insoluble oligomers are involved in polyglutamine degeneration (2008)

In polyglutamine (polyQ) degeneration, disease protein that carries an expanded polyQ tract is neurotoxic. Expanded polyQ protein exists in different conformations that display distinct solubility properties. In this study, an inducible transgenic Drosophila model is established to define the pathogenic form of polyQ protein at an early stage of degeneration in vivo. We show that microscopic polyQ aggregates are neither pathogenic nor protective. Further, no toxic effect of sodium dodecyl sulfate (SDS) -soluble polyQ protein is observed in our model. By means of filtration, 2 forms of SDS-insoluble protein species are identified according to their size. Coexpression of an ATPase-defective form of the molecular chaperone Hsc70 (Hsc70-K71S) selectively reduces the abundance of the large SDS-insoluble polyQ species, but such modulation has no modifying effects on degeneration. Notably, we detect a distinct Hsc70-K71S-resistant, small, SDS-insoluble polyQ oligomeric species that is closely correlated with degeneration. Our data highlight the toxic role of SDS-insoluble oligomers in polyQ degeneration in vivo.
Laurence-Moon-Biedl Syndrome (1948)

The association of retinitis pigmentosa with polydactylism was recorded in 1860 by Laurence and Moon and the Fr6hlich syndrome in 1901.Biedl in 1921 described the pentad of polydactylism, obesity, hypogenitalia, retinitis pigmentosa, and mental retardation, with a familial occur- rence; the association being now known as the Laurence- Moon-Biedl syndrome.Variants have also been described by Biesmond, Van Bogaert, and by Delhaye in which coloboma of the iris replaced the retinal degeneration.Graefe in 1866 described optic atrophy as complicating oxycephaly, but not of the pigmentary degenerative type (Duke-Elder, 1940; Ridley and Sorsby, 1940).Mann (1937), however, records oxycephaly as one of the skeletal abnormalities which may be present with the syndrome.Retinitis pigmentosa occurs much more often as an isolated disability than in combination with other dis- abilities.Nettleship worked out many pedigrees in which there was no other defect.Usher obtained similar results when searching especially for combined defects.In the Eugenics Laboratory Memoirs (1922) is reported a series of 914 cases, in 656 of which the patients suffered from retinitis pigmentosa alone.Deaf-mutism, or mental deficiency, occurred in 96 cases (10.41 %), and was the commonest associated affliction.In only 9 cases (less than %) was polydactylism noted; such a combination is therefore rare.The genealogical tables constructed showed that retinitis pigmentosa could apparently be transmitted as an inherited Mendelian dominant, or recessive, or sex-linked character, whereas the Laurence-Moon-Biedl syndrome occurred as a recessive Mendelian type (Eugenics Laboratory Memoirs, 1922).Pathological evidence of pituitary abnormality has gener- ally been indefinite and disappointing.Dax (1938), how- ever, reported the presence in the blood and urine, but not in the cerebrospinal fluid, of a substance which was melanophore-expanding in frogs and caused a visible
Increased cyclic guanosine monophosphate production and overexpression of atrial natriuretic peptide A-receptor mRNA in spontaneously hypertensive rats. (1993)

Atrial natriuretic peptide (ANP) specifically stimulates particulate guanylate cyclase, and cyclic guanosine monophosphate (cGMP) has been recognized as its second messenger. Spontaneously hypertensive rats (SHR) have elevated plasma ANP levels, but manifest an exaggerated natriuretic and diuretic response to exogenous ANP when compared to normotensive strains. In isolated glomeruli, the maximal cGMP response to ANP corresponds to a 12- to 14-fold increase over basal levels in normotensive strains (Wistar 13 +/- 2; Wistar-Kyoto 12 +/- 2; Sprague-Dawley 14 +/- 2) while a maximal 33 +/- 3-fold elevation occurs in SHR (P < 0.001). This hyperresponsiveness of cGMP is reproducible in intact glomeruli from SHR from various commercial sources. Furthermore, this abnormality develops early in life, even before hypertension is clearly established, and persists despite pharmacological modulation of blood pressure, indicating that it is a primary event in hypertension. In vitro studies have revealed a higher particulate guanylate cyclase activity in membranes from glomeruli and other tissues from SHR. This increase is not accounted for by different patterns of ANP binding to its receptor subtypes between normotensive and hypertensive strains, as assessed by competitive displacement with C-ANP102-121, an analog which selectively binds to one ANP receptor subtype. The hyperactivity of particulate guanylate cyclase in SHR and its behavior under basal, ligand (ANP), and detergent-enhanced conditions could be attributed either to increased expression or augmented sensitivity of the enzyme. Radiation-inactivation analysis does not evoke a disturbance in the size of regulatory elements normally repressing enzymatic activity, while the expression of particulate guanylate cyclase gene using mutated standard of A- and B-receptors partial cDNAs, quantified by polymerase chain reaction (PCR) transcript titration assay, manifests a selective increase of one guanylate cyclase subtype. Our data suggest that in hypertension, genetic overexpression of the ANP A-receptor subtype is related to the exaggerated biological response to ANP in this disease.
Transdermal Absorption of Dimethindene in Man (1995)

Dimethindene and its metabolite N-demethyldimethindene were determined in human urine after dermal administration of dimethindene. The HPLC-method used was previously described. Data of 8 volunteers are presented. After 32 h an average of 0.023% of the administered dose of dimethindene and 0.022% of N-demethyldimethindene were excreted into urine. Since also after oral administration of dimethindene only about 1% of unmetabolised dimethindene is found in urine it can be concluded that a certain amount of dimethindene is absorbed through the skin after dermal administration.
A single-chip 75 GHz/0.35 μm SiGe BiCMOS W-CDMA homodyne transceiver for UMTS mobiles (2004)

A single-chip, fully-integrated 3G UMTS/W-CDMA transceiver has been implemented in a standard 75-GHz/0.35 /spl mu/m SiGe BiCMOS process for use in FDD mobile terminals. The design comprises two integer-N/fractional-N synthesizers with fully integrated CMOS VCOs, on-chip tuning and PLL, a zero-IF receiver and a direct-conversion transmitter. The zero-IF receiver includes a differential-input, bipolar, low-noise amplifier (2nd LNA), a down-converter with CMOS Gilbert type mixers followed by a low-noise buffer amplifier, an analog active baseband filter of 5th-order with automatic on-chip filter calibration and interleaved with a programmable gain amplifier, and a programmable baseband output buffer. The direct-conversion transmitter includes a 4th-order analog active baseband filter, a bipolar direct modulation up-converter, and a variable gain RF amplifier with >80 dB gain control range, and a 3 dBm power amplifier driver. The transceiver is fully-programmable via two serial 3-wire-bus interfaces.. The device operates at 2.7-3.0 V supply and consumes 35 mA and 53-78 mA, in the receive mode and in the transmit mode, respectively. The transceiver is mounted in a small outline, 40-pin, leadless, 5.5/spl times/6.5 mm/sup 2/ surface mount package and fully complies with ARIB W-CDMA and UMTS standards.
Paper 19: Slow Transient Compressible Flow through Orifices (1967)

The discharge of compressed air from a cylinder has been studied experimentally. The effect of initial pressure and of orifice geometry on the expansion in the cylinder and on the transient flow through the orifice has been examined in detail. During expansion, radial and axial temperature gradients are established which result in departures from isentropic behaviour. The state can be reproduced analytically only by using a variable polytropic index whose values are dependent on the history of the expansion. From dimensional considerations the effects of fluid dynamical variables and of heat transfer on the transient flow have been isolated.
Bacillopeptins, New Cyclic Lipopeptide Antibiotics from Bacillus subtilis FR-2. (1995)

Bacilopeptins, new iturin-group antifungal antibiotics, were isolated from the culture broth of Bacillus subtilis FR-2 obtained from the rhizosphere of garlic suffering from the basal rot caused by Fusarium oxysporum. Their structures were elucidated to be cyclic lipopeptides similar to bacillomycin L by NMR and mass spectral studies coupled with amino acid analysis. The absolute configuration of each amino acid residue was determined by chiral HPLC.
A comparison of successful and failed protein interface designs highlights the challenges of designing buried hydrogen bonds (2012)

The accurate design of new protein-protein interactions is a longstanding goal of computational protein design. However, most computationally designed interfaces fail to form experimentally. This investigation compares five previously described successful de novo interface designs with 158 failures. Both sets of proteins were designed with the molecular modeling program Rosetta. Designs were considered a success if a high-resolution crystal structure of the complex closely matched the design model and the equilibrium dissociation constant for binding was less than 10 μM. The successes and failures represent a wide variety of interface types and design goals including heterodimers, homodimers, peptide-protein interactions, one-sided designs (i.e., where only one of the proteins was mutated) and two-sided designs. The most striking feature of the successful designs is that they have fewer polar atoms at their interfaces than many of the failed designs. Designs that attempted to create extensive sets of interface-spanning hydrogen bonds resulted in no detectable binding. In contrast, polar atoms make up more than 40% of the interface area of many natural dimers, and native interfaces often contain extensive hydrogen bonding networks. These results suggest that Rosetta may not be accurately balancing hydrogen bonding and electrostatic energies against desolvation penalties and that design processes may not include sufficient sampling to identify side chains in preordered conformations that can fully satisfy the hydrogen bonding potential of the interface.
No visible electrochromism in high-quality e-beam evaporated In_2O_3:Sn films (1985)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. S. E. M. Svensson and C. G. Granqvist, "No visible electrochromism in high-quality e-beam evaporated In2O3:Sn films," Appl. Opt. 24, 2284-2285 (1985) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
INFLUENCE OF CONSTITUTION ON ADHESION (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTINFLUENCE OF CONSTITUTION ON ADHESIONW. A. ZismanCite this: Ind. Eng. Chem. 1963, 55, 10, 18–38Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ie50646a003https://doi.org/10.1021/ie50646a003research-articleACS PublicationsRequest reuse permissionsArticle Views1423Altmetric-Citations438LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Highly correlated systems. Excitation energies of first row transition metals Sc–Cu (1989)

The low-lying dns2→dn+1s1 excitation energies of the first row transition metal atoms Sc–Cu are calculated using fourth-order M≂ller–Plesset perturbation theory (MP4) as well as quadratic configuration interaction (QCI) techniques with large spd and spdf basis sets. The MP4 method performs well for Sc–Mn but fails dramatically for Fe–Cu. In contrast, the QCI technique performs uniformly for all excitation energies with a mean deviation from experiment of only 0.14 eV after including relativistic corrections. f functions contribute 0.1–0.4 eV to the excitation energies for these systems. The highly correlated d10 state of the Ni atom is also considered in detail. The QCI technique obtains the d9s1→d10 splitting of the Ni atom with an error of only 0.13 eV. The results show that single-configuration Hartree–Fock based methods can be successful in calculating excitation energies of transition metal atoms.
Macrophage Stimulation Activity of the Polysaccharide Fraction from a Marine Alga (<i>Porphyra yezoensis</i>): Structure-Function Relationships and Improved Solubility (1995)

The polysaccharide fraction from Porphyra yezoensis (PASF) has already been shown to stimulate murine phagocytic functions in vivo and in vitro [Y. Yoshizawa et al., Biosci. Biotech. Biochem., 57, 1862-1866 (1993)]. In this study, various treatments were applied to PASF to assess its structure-function relationships. Desulfation of PASF decreased in vitro macrophage-stimulation activity, while further sulfation of PASF did not change the activity. Among 7 fractions obtained by anion-exchange chromatography of PASF, stronger activity was found in the fractions having a lower or higher sulfate content than in those having a medium sulfate content. Digests of PASF with beta-agarase showed higher activity and solubility, and lower viscosity, than undigested PASF. These results indicate that the sulfate groups in PASF, probably porphyran, contributed to the macrophage stimulating activity, although a larger number of sulfate groups did not always cause stronger activity.
Zymogen activation as a sensitive enzymeamplifying assay for a protease with tryptic specificity (1970)

A protease, ;trypsinogenase', secreted in small amounts by the sea-urchin blastula, is assayed in two steps as an example of enzyme-amplifying kinetics. In reaction 1 the trypsinogenase catalyses the activation of trypsinogen to trypsin. In reaction 2 the trypsin catalyses the hydrolysis of N-alpha-toluene-p-sulphonylarginine methyl ester, at a rate that is linear with trypsinogenase concentration over a 20-fold range. Results are reproducible within a batch of zymogen, but each batch requires a separate standard curve.
Market Guide to Fleet Telematics Services: Creating a Consumer's Guide to Currently Available Aftermarket Solutions (2012)

This report documents an effort to review the currently available, aftermarket telematics solutions. The project involved: (a) a survey of the current telematics market; (b) a review of the available telematics systems; (c) an analysis of the usefulness of each identified system; and (d) the creation of a findings summary document formatted as a consumer market guide to telematics systems. The detailed consumer market guide is included and follows the report.
Design of HIFU Transducers for Generating Specified Nonlinear Ultrasound Fields (2016)

Various clinical applications of high-intensity focused ultrasound have different requirements for the pressure levels and degree of nonlinear waveform distortion at the focus. The goal of this paper is to determine transducer design parameters that produce either a specified shock amplitude in the focal waveform or specified peak pressures while still maintaining quasi-linear conditions at the focus. Multiparametric nonlinear modeling based on the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation with an equivalent source boundary condition was employed. Peak pressures, shock amplitudes at the focus, and corresponding source outputs were determined for different transducer geometries and levels of nonlinear distortion. The results are presented in terms of the parameters of an equivalent single-element spherically shaped transducer. The accuracy of the method and its applicability to cases of strongly focused transducers were validated by comparing the KZK modeling data with measurements and nonlinear full diffraction simulations for a single-element source and arrays with 7 and 256 elements. The results provide look-up data for evaluating nonlinear distortions at the focus of existing therapeutic systems as well as for guiding the design of new transducers that generate specified nonlinear fields.
A Method of Time-Coded Parallel Planes of Light for Depth Measurement (1981)

Lark-Loop suture technique has biomechanical properties comparable to Krackow and superior to the Lasso-Loop in terms of suture displacement, ultimate load to failure, and stiffness. Therefore, the Lark-Loop suture fixation technique may be beneficial for arthroscopic biceps tenodesis.