gebhart/patrepeval huggingface dataset:
3D-ProWiz: An Energy-Efficient and Optically-Interfaced 3D DRAM Architecture with Reduced Data Access Overhead (2015)

This paper introduces 3D-ProWiz, which is a high-bandwidth, energy-efficient, optically-interfaced 3D DRAM architecture with fine grained data organization and activation. 3D-ProWiz integrates sub-bank level 3D partitioning of the data array to enable fine-grained activation and greater memory parallelism. A novel method of routing the internal memory bus to individual subarrays using TSVs and fanout buffers enables 3D-ProWiz to use smaller dimension subarrays without significant area overhead. The use of TSVs at subarray-level granularity eliminates the need to use slow and power hungry global lines, which in turn reduces the random access latency and activation-precharge energy. 3D-ProWiz yields the best latency and energy consumption values per access among other well-known 3D DRAM architectures. Experimental results with PARSEC benchmarks indicate that 3D-ProWiz achieves 41.9 percent reduction in average latency, 52 percent reduction in average power, and 80.6 percent reduction in energy-delay product (EDP) on average over DRAM architectures from prior work.
V3 versican isoform expression alters the phenotype of melanoma cells and their tumorigenic potential (2005)

Versican is a large chondroitin sulfate proteoglycan produced by several tumor cell types, including malignant melanoma. The expression of increased amounts of versican in the extracellular matrix may play a role in tumor cell growth, adhesion and migration. We have expressed the V3 isoform of versican in human and canine melanoma cell lines. Retroviral overexpression of V3 did not change the morphology of any of the cell lines but markedly reduces cell growth in the V3 versican expressing melanoma cells. The V3-overexpressing melanoma cells retain their diminished growth potential in vivo because primary tumors arising from these cell lines growth more slowly than their vector only counterparts. This effect was accompanied by increases in cell adhesion on hyaluronan and an enhanced ability to migrate on hyaluronan-coated transwell chambers. This enhanced migration is blocked when cells are preincubated with soluble hyaluronan, or anti-CD44 antibodies, suggesting that V3 acts by altering the hyaluronan-CD44 interaction. Hyaluronan content and CD44 expression are not altered in V3-overexpressing cells compared to vector-transduced cells. Our results show that V3 overproduction modulates the in vitro behavior of human and canine melanoma cell lines and reduces their tumorigenicity in vivo.
The Church under Communism (1953)

Journal Article The Church under Communism Get access The Church Under Communism. London, SCM Press, 1952. 79 pp. 812′​′×512′​′⁠. 5s. Robert Smith Robert Smith Search for other works by this author on: Oxford Academic Google Scholar International Affairs, Volume 29, Issue 2, April 1953, Page 206, https://doi.org/10.2307/2608989 Published: 01 April 1953
Configuration synthesis for a heterogeneous backbone cluster and a PC-interface network (1989)

The design is discussed of the Locus family of networks rendering PC interface (PCI) service. Given are the expected user workload, the hardware costs, and the performance constraints. The workload consists of three classes of users: interactive, highly-interactive, and communication-intensive. The number of PCs is given and is equal to the number of users. It is shown that the problem can be reduced to a discrete capacity and flow assignment (CFA) problem. The backbone capacity assignment is inspired by the Lagrangian decomposition approach. It starts from a backbone capacity assignment which matches the initial flow and chooses a backbone server upgrade that gives the greatest response-time reduction per dollar. At this point, the flow deviation method is applied and iteration is continuous until the constraints are met. Several computational examples of network configuration synthesis are presented that emphasize the significance and generality of the results obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
P239 Returning sexually transmitted infection results to adolescents: a review of the literature (2017)

Introduction Sexually Transmitted Infections (STIs) are an important cause of poor reproductive and sexual health in adolescents. Prompt diagnosis and treatment are key to reducing long term sequelae. We reviewed the evidence on current methods of results delivery for STIs, with a focus on adolescent services. Method The literature was reviewed systematically between June and August 2016. Six databases were searched, reference lists reviewed and authors contacted for studies on methods of results delivery for STIs to adolescents (aged 15–25 years). Titles and abstracts were reviewed and full text obtained for quality assessment and data extraction. Results Of 549 studies identified, 19 fulfilled the inclusion criteria. Seven studies focused on adolescent populations, all in high-income settings. Three studies in low- and middle-income settings and nine included adolescents as a stratified group. Twelve studies were cross-sectional, two randomised control trials, the remaining employed mixed methods. Outcome measures varied widely, percentage preferences for method of results being the commonest measure. Findings show that mobile phone call and text were the commonest methods of returning results. Other modalities including text message, email and online notification demonstrated wide variations in acceptability. Preferences varied according to type of result, population type, location, client group and previous service use. Mobile phone calls and face-to-face consultations remain highly acceptable. Discussion The use of mHealth offers promising options for STI results delivery. Methods adopted must consider the target population accounting for gender, age, ethnicity and access to technologies. Customisation is recommended to meet user requirements for optimal health care delivery.
Aetiology of ulcerative colitis. (1969)

Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles possess potent antiproliferative activity against certain cancer cells, similar to the unfluorinated 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495). In “sensitive” cancer cells, DF 203 is metabolized by, can induce expression of, and binds covalently to CYP1A1. Metabolism appears to be essential for its antiproliferative activity through DNA adduct formation. However, a biphasic dose-response relationship compromises its straightforward development as a chemotherapeutic agent. We investigated whether fluorinated benzothiazoles inhibit cancer cell growth without the biphasic dose-response, and whether the fluorinated benzothiazoles are also metabolized into reactive species, with binding to macromolecules in sensitive cancer cells. One fluorinated benzothiazole, 2-(4-amino-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) did exhibit potent, antiproliferative activity without a biphasic dose-response. The fluorinated benzothiazoles were also metabolized only in cells, which subsequently showed evidence of cell death. We used microsomes from genetically engineered human B-lymphoblastoid cells expressing cytochromes P450 (CYP1A1, CYP1A2, or CYP1B1) to clarify the basis for fluorinated benzothiazole metabolism. 5F 203 induced CYP1A1 and CYP1B1 mRNA expression in sensitive breast and renal cancer cells, whereas 5F 203 induced CYP1A1 mRNA but not CYP1B1 mRNA expression in sensitive ovarian cancer cells. 5F 203 did not induce CYP1A1 or CYP1B1 mRNA expression in any “resistant” cancer cells. The fluorinated benzothiazoles induced CYP1A1 protein expression exclusively in sensitive cells. [<sup>14</sup>C]5F 203 bound substantially to subcellular fractions in sensitive cells but only minimally in resistant cells. These data are concordant with the antiproliferative activity of fluorinated benzothiazoles deriving from their ability to become metabolized and bind to macromolecules within sensitive cells.
Spatiotemporal Interactions in the Visual Cortex Following Paired Electrical Stimulation of the Retina (2014)

Interactions between sequential stimulation of pairs of electrodes in a suprachoroidal retinal prosthesis occur for delays up to 100 ms and electrode separations of several millimeters. Knowledge of these spatiotemporal interactions is essential for developing effective patterns of stimulation for retinal prostheses.
Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease (2008)

Alzheimer's disease (AD) affects more than 18 million people worldwide and is characterized by progressive memory deficits, cognitive impairment and personality changes. The main cause of AD is generally attributed to the increased production and accumulation of amyloid-beta (Abeta), in association with neurofibrillary tangle (NFT) formation. Increased levels of pro-inflammatory factors such as cytokines and chemokines, and the activation of the complement cascade occurs in the brains of AD patients and contributes to the local inflammatory response triggered by senile plaque. The existence of an inflammatory component in AD is now well known on the basis of epidemiological findings showing a reduced prevalence of the disease upon long-term medication with anti-inflammatory drugs, and evidence from studies of clinical materials that shows an accumulation of activated glial cells, particularly microglia and astrocytes, in the same areas as amyloid plaques. Glial cells maintain brain plasticity and protect the brain for functional recovery from injuries. Dysfunction of glial cells may promote neurodegeneration and, eventually, the retraction of neuronal synapses, which leads to cognitive deficits. The focus of this review is on glial cells and their diversity properties in AD.
Further Desensitized FIR Halfband Filters (2015)

A halfband filter's sensitivity to coefficient quantization can be significantly reduced by constructing the filter as a cascade of sections. The further desensitized FIR halfband filter presented here has an increased reduction in coefficient sensitivity. This is accomplished by doubling the number of extracted (1+z <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> ) blocks in the cascade filter structure. The relationship between the resulting further-desensitized halfband filter's structure and the halfband filter's transfer function is also demonstrated through reasoning, as well as showing the same for the previous desensitized halfband filter, for which the present filter represents an improvement. Further, it is shown how such insensitivity can be exploited in the filter-design process to yield halfband filters with reduced hardware complexity, leading to lower power consumption and/or higher operating speeds.
Ku80 plays a role in non‐homologous recombination but is not required for T‐DNA integration in<i>Arabidopsis</i> (2003)

Chromosomal breaks are repaired by homologous recombination (HR) or non-homologous end joining (NHEJ) mechanisms. The Ku70/Ku80 heterodimer binds DNA ends and plays roles in NHEJ and telomere maintenance in organisms ranging from yeast to humans. We have previously identified a ku80 mutant of the model plant Arabidopsis thaliana and shown the role of Ku80 in telomere homeostasis in plant cells. We show here that this mutant is hypersensitive to the DNA-damaging agent methyl methane sulphonate and has a reduced capacity to carry out NHEJ recombination. To understand the interplay between HR and NHEJ in plants, we measured HR in the absence of Ku80. We find that the frequency of intrachromosomal HR is not affected by the absence of Ku80. Previous work has clearly implicated the Ku heterodimer in Agrobacterium-mediated T-DNA transformation of yeast. Surprisingly, ku80 mutant plants show no defect in the efficiency of T-DNA transformation of plants with Agrobacterium, showing that an alternative pathway must exist in plants.
Physico‐chemical Properties of Marine Phospholipid Emulsions (2012)

Abstract Many studies have shown that marine phospholipids (PL) have better bioavailability, better resistance towards oxidation and contain higher polyunsaturated fatty acids such as eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) than triglycerides (TAG) present in fish oil. The objective of this study was to investigate the emulsifying properties of various commercial marine PL and the feasibility of using them to prepare stable emulsions prepared with or without addition of fish oil. In addition, this study also investigated the relationship between chemical composition of marine PL and the stability of their emulsions. Physical stability was investigated through particle size distribution (PSD), zeta potential, microscopy inspection and emulsion separation (ES); while the oxidative and hydrolytic stability of emulsions were investigated through peroxide value (PV) and free fatty acids value (FFA) after 32 days storage at room temperature and at 2 °C. In conclusion, marine PL showed good emulsifying properties and it was possible to prepare marine PL emulsions with and without addition of fish oil. Emulsion with both good oxidative stability and physical stability could be prepared by using marine PL of high purity, less TAG, more PL, cholesterol and higher antioxidant content.
Composite bearing and seal materials for advanced heat engine applications to 900 degree C (1990)

Plasma sprayed composite coatings of metal-bonded chromium carbide with additions of silver and thermochemically stable fluorides were previously reported to be lubricative in pin on disk bench tests from room temperature to 900{degree}C. An early coating formulation of this type, designated as PS200, was successfully tested as a cylinder coating in a Stirling engine at a TRRT of 760{degree}C (1450{degree}F) in a hydrogen atmosphere, and as a backup lubricant for gas bearings to 650{degree}C (1250{degree}F). A subsequent optimization program as shown that tribological properties are further improved by increasing the solid lubricant content. The improved coating is designated as PS212. The same powder formulation has been used to make free-standing powder metallurgy (PM212) parts by sintering or hot isostatic pressing. The process is very attractive for making parts that cannot be readily plasma sprayed such as bushings and cylinders that have small bore diameters and/or high length to diameter ratios. The properties of coatings and free-standing parts fabricated from these powders are reviewed. 6 refs., 14 figs., 1 tab.
Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance. (2003)

Overexpression of Bcl-2 plays a role in the development of drug resistance in leukemia and other apoptosis-prone tumors. Raf isoforms areserine/threonine kinases that act as signal transducers in cascades initiated by many growth factors and mitogens. Raf isoform activation has been linked to drug resistance in leukemia. In this study we investigated effects of Bcl-2 and Raf-1 on doxorubicin-induced growth inhibition of MCF-7 breast cancer cells. In the absence of doxorubicin, overexpression of Bcl-2 or a constitutively active form of Raf-1 in MCF-7 cells did not affect proliferation rate. Overexpression of Bcl-2 increased resistance of MCF-7 cells to doxorubicin in 2-day, 5-day, and 8-week assays. Analysis of doxorubicin sensitivity of individual MCF/Bcl-2 clones showed that doxorubicin resistance was positively correlated with level of Bcl-2 overexpression. Overexpression of constitutively active Raf-1 also increased resistance to doxorubicin. Induction of Raf-1 activity in MCF-7 cells overexpressing Bcl-2 resulted in greater doxorubicin resistance than induction of Raf-1 activity in MCF-7 cells lacking Bcl-2 overexpression. Furthermore, levels of P-glycoprotein mRNA were increased in MCF-7 cells overexpressing a constitutively active Raf-1. MCF-7 cells overexpressing constitutively active Raf-1 were also more resistant to paclitaxel, which, like doxorubicin, is a substrate of P-glycoprotein. These observations suggest both independent and overlapping roles for Raf-1 and Bcl-2 oncogenes in the resistance to growth inhibition by doxorubicin.
Current Source Inverter‐Fed Drives (2005)

This chapter contains sections titled: Introduction CSI Drives with PWM Rectifiers Transformerless CSI Drive for Standard AC Motors CSI Drive with Multipulse SCR Rectifier LCI Drives for Synchronous Motors Summary References
Automation of differential blood count (2004)

A technique for automating the differential count of blood is presented. The proposed system takes, as input, color images of stained peripheral blood smears and identifies the class of each of the white blood cells (WBC), in order to determine the count of cells in each class. The process involves segmentation, feature extraction and classification. WBC segmentation is a two-step process carried out on the HSV-equivalent of the image, using k-means clustering followed by the EM-algorithm. Features extracted from the segmented cytoplasm and nucleus, are motivated by the visual cues of shape, color and texture. Various classifiers have been explored on different combinations of feature sets. The results presented are based on trials conducted with normal cells. For training the classifiers, a library set of 50 patterns, with about 10 samples from each class, is used. The test data, disjoint from the training set, consists of 34 patterns, fairly represented by every class. The best classification accuracy of 97% is obtained using neural networks, followed by 94% using SVM.
Design and development of rotor quality test system for die-cast copper rotors (2016)

It is very well known to the market that copper rotor motor can give good efficiency at par with new era motors and handle higher temperatures to qualify for electric vehicle application. Being a heavy metal; die-cast copper rotor manufacturing needs absolute care for faithful rotor production. In this paper the common faults in copper die-cast processing are being identified and sufficient monitoring methods are suggested in a three stage inspection. The final stage consists of a rotor quality test system; which detects all usual problems found in copper die-cast rotors. This rotor quality test system analysis helps to optimize the rotor manufacturing process and avoid the circumstances of fitting an inferior rotor in the motor assembly.
Intestinal Permeability and Postheparin Plasma Diamine Oxidase Activity in the Prediction of Crohnʼs Disease Relapse (1999)

A method of detecting presymptomatic relapse of Crohn's disease could allow for the selective use of maintenance or intensified medical therapy in those with an increased risk of relapse. The aim of this study was to evaluate three potential laboratory markers of relapse: intestinal and gastroduodenal permeability and plasma diamine oxidase activity. Intestinal permeability (lactulose/mannitol test), gastroduodenal permeability (urinary sucrose excretion), and postheparin plasma diamine oxidase activity were serially measured in 61 adults with Crohn's disease in remission (CDAI <150) for at least 30 days. Subjects were followed periodically for clinical relapse (CDAI >150 and increased by at least 100 points or the need for steroids or surgery). Fourteen patients (23%) relapsed. A cut-off of 0.030 for the lactulose/mannitol ratio was defined. Those with ratios above the cutoff had a 7.0 times greater risk of relapse (p<0.001). Three subjects who went from a normal ratio to an abnormal ratio relapsed, whereas none of 32 subjects with a repeatedly normal ratio relapsed. Sucrose excretion and plasma diamine oxidase activity did not predict relapse. Serial testing of intestinal permeability, but not of gastroduodenal permeability or plasma diamine oxidase activity, was useful in predicting relapse in asymptomatic patients.
Hydraulic Performance of Coanda-Effect Screens (2001)

A theoretically based computational model is presented for predicting the hydraulic performance of Coanda-effect screens. These screens use a tilted-wire, wedge-wire screen panel to remove thin layers of high-velocity flow from the bottom edge of a supercritical flow. Typical slot openings are 1 mm or less, and the screens are self-cleaning with no moving parts. The discharge characteristics of several screen materials were evaluated in laboratory tests, and a relation was developed for computing the discharge through a tilted-wire screening surface as a function of the Froude number, the specific energy, and the Reynolds and Weber numbers. A model for the performance of complete Coanda-effect screen structures predicts the wetted length of screen required to accept a given flow, or the flow rate through the screen and the bypass flow over a screen that does not accept all of the flow. Predictions from the model compare favorably to results from clean-water laboratory tests of several different prototype-size screen structures. The model will allow designers to accurately size screens and evaluate design alternatives.
Diatom-associated bacteria are required for aggregation of <i>Thalassiosira weissflogii</i> (2010)

Aggregation of algae, mainly diatoms, is an important process in marine systems leading to the settling of particulate organic carbon predominantly in the form of marine snow. Exudation products of phytoplankton form transparent exopolymer particles (TEP), which acts as the glue for particle aggregation. Heterotrophic bacteria interacting with phytoplankton may influence TEP formation and phytoplankton aggregation. This bacterial impact has not been explored in detail. We hypothesized that bacteria attaching to Thalassiosira weissflogii might interact in a yet-to-be determined manner, which could impact TEP formation and aggregate abundance. The role of individual T. weissflogii-attaching and free-living new bacterial isolates for TEP production and diatom aggregation was investigated in vitro. T. weissflogii did not aggregate in axenic culture, and striking differences in aggregation dynamics and TEP abundance were observed when diatom cultures were inoculated with either diatom-attaching or free-living bacteria. The data indicated that free-living bacteria might not influence aggregation whereas bacteria attaching to diatom cells may increase aggregate formation. Interestingly, photosynthetically inactivated T. weissflogii cells did not aggregate regardless of the presence of bacteria. Comparison of aggregate formation, TEP production, aggregate sinking velocity and solid hydrated density revealed remarkable differences. Both, photosynthetically active T. weissflogii and specific diatom-attaching bacteria were required for aggregation. It was concluded that interactions between heterotrophic bacteria and diatoms increased aggregate formation and particle sinking and thus may enhance the efficiency of the biological pump.