gebhart/patrepeval huggingface dataset:
Comparison of mobility-limiting mechanisms in high-mobility Si1−<i>x</i>Ge<i>x</i> heterostructures (1993)

Relaxed Si1−xGex buffers on Si have yielded record low-temperature mobilities for both electrons and holes in the Si–Ge system. We analyze various limitations on this mobility, including scattering from remote dopants, background impurities, interface roughness, alloy fluctuations, and the specific strain, morphology, and threading dislocations expected for relaxed alloy buffers. Comparison with experiments eliminates all but the first four as potential limitations on the mobility.
Ataxin-3 Is a Histone-binding Protein with Two Independent Transcriptional Corepressor Activities (2002)

The mechanisms of pathology for the family of polyglutamine disease proteins are unknown; however, recently it was shown that several of these proteins inhibit transcription suggesting that transcriptional repression may be a potential mechanism for pathology. In the present study we use cell transfections, in vitro binding, co-immunoprecipitations, and reporter assays to show that the polyglutamine disease protein, ataxin-3, interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein, p300, and p300/CREB-binding protein-associated factor and inhibits transcription by these coactivators. Importantly, endogenous ataxin-3 is co-immunoprecipitated with each of these coactivators in non-transfected cells. The C-terminal polyglutamine-containing domain of ataxin-3 inhibits coactivator-dependent transcription and is required for binding coactivators. The N-terminal domain of ataxin-3 inhibits histone acetylation by p300 in vitro and inhibits transcription in vivo. Histone binding and blocking access of coactivators to acetylation sites on histones appears to be the mechanism of inhibition. Together, our data provide a novel mechanism of transcriptional regulation by ataxin-3 that involves targeting histones, coactivators, and an independent mode of direct repression of transcription, and suggests that its physiological function and possibly pathological effects are linked to its interactions with these proteins.
Effects of low-dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials (2009)

Although low-dose enoximone appears to be safe in patients with advanced HF, major clinical outcomes are not improved.
Serological relationship of tumor necrosis factor-inducing exoantigens of Plasmodium falciparum and Plasmodium vivax (1992)

Exoantigens of Plasmodium vivax-parasitized erythrocytes stimulated macrophages to secrete tumor necrosis factor, and antisera raised against the exoantigens inhibited this secretion. The antisera also inhibited the activity of Plasmodium falciparum and Plasmodium yoelii exoantigens, and conversely, antisera against the latter cross-reacted with the exoantigens of P. vivax.
Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia (2007)

Respiratory viral infections are associated with an increased risk of asthma, but how acute Th1 antiviral immune responses lead to chronic inflammatory Th2 disease remains undefined. We define a novel pathway that links transient viral infection to chronic lung disease with dendritic cell (DC) expression of the high-affinity IgE receptor (FcepsilonRIalpha). In a mouse model of virus-induced chronic lung disease, in which Sendai virus triggered a switch to persistent mucous cell metaplasia and airway hyperreactivity after clearance of replicating virus, we found that FceRIa(-/-) mice no longer developed mucous cell metaplasia. Viral infection induced IgE-independent, type I IFN receptor-dependent expression of FcepsilonRIalpha on mouse lung DCs. Cross-linking DC FcepsilonRIalpha resulted in the production of the T cell chemoattractant CCL28. FceRIa(-/-) mice had decreased CCL28 and recruitment of IL-13-producing CD4(+) T cells to the lung after viral infection. Transfer of wild-type DCs to FceRIa(-/-) mice restored these events, whereas blockade of CCL28 inhibited mucous cell metaplasia. Therefore, lung DC expression of FcepsilonRIalpha is part of the antiviral response that recruits CD4(+) T cells and drives mucous cell metaplasia, thus linking antiviral responses to allergic/asthmatic Th2 responses.
Regulating the angiogenic balance in tissues: A potential role for the proliferative state of fibroblasts (2008)

A balance between angiogenesis inducers and inhibitors in the microenvironment controls the rate of new blood vessel formation. We hypothesized that fibroblasts, an important cellular constituent of the tissue stroma, secrete molecules that contribute to this balance. We further hypothesized that fibroblasts secrete molecules that promote angiogenesis when they are in a proliferative state and molecules that inhibit angiogenesis when they are not actively cycling (quiescent). Microarray analysis revealed that angiogenesis inducers and inhibitors are regulated as fibroblasts transition into a quiescent state and reenter the cell cycle in response to changes in serum. To assess whether changes in transcript levels result in changes in the levels of secreted proteins, we collected conditioned medium from proliferating and quiescent fibroblasts and performed immunoblotting for selected proteins. Secreted protein levels of the angiogenesis inhibitor pigment epithelium derived factor (PEDF) were higher in quiescent than proliferating fibroblasts. Conversely, proliferating fibroblasts secreted increased levels of the angiogenesis inducer vascular endothelial growth factor-C (VEGF-C). For the angiogenesis inhibitor thrombospondin-2, quiescent cells secreted a prominent 160 kDa form in addition to the 200 kDa form secreted by proliferating and restimulated fibroblasts. Using immunohistochemistry we discovered that fibroblasts surround blood vessels and that the angiogenesis inhibitor PEDF is expressed by quiescent fibroblasts in uterine tissue, supporting a role for PEDF in maintaining quiescence of the vasculature. This work takes a new approach to the study of angiogenesis by examining the expression of multiple angiogenesis regulators secreted from a key stromal cell, the fibroblast.
Awareness about the Importance of Nutrition During Pregnancy Among Women in Child Bearing Age: A Quantitative Study Among Urban Women. (2020)

Introduction An adequate nutrition pattern is of major importance for one’s health and well-being, especially during pregnancy when a woman undergoes major biological, physical, psychological and social transformations. Macronutrient and micronutrient deficiencies predispose the fetus to preterm birth, neural tube defects, and low birth weight for gestational age. This study was conducted to determine the nutrition awareness of women in childbearing age in order to provide a greater understanding of the life course perspective (LCP) in relation to nutrition behaviors and pregnancy. Methods A cross-sectional study was conducted on based on our conceptualization of nutrition awareness and questionnaire based studies of a face-to-face interview. The participants were women with age group of 17 years to 45 years participate in studies in Jeddah city. Data collection procedures A Semi-structured questionnaires prepared in English language were translated in to Arabic and then translated back to English to check for consistency. The questionnaires were pretested Human ethical committee; the questions assessed respondents’ nutrition knowledge. Results and discussion Different questions were asked to 175 selected pregnant women to be included in this study assess knowledge of pregnant mothers on nutrition and determinant factors in the study area. Most of the respondents (34.85.2%) were in 19-25 years of age group.69.1 % (n=121) women says they pay attention to the number of soft drinks they drink each day. There would be fascinating to study awareness of specific nutrients and related issues, like consumption folic acid, non-vegetarian diet, minerals and life style such as mental stress and physical exercise.
Improving wearable slot antenna performance with EBG structures (2008)

This paper presents a 2.8 GHz slot antenna over an EBG (Electromagnetic Band Gap) substrate with the objective of higher antenna efficiency, wide bandwidth and compact operation in close proximity to the human body. To achieve compact size, two different size EBGs are developed and the antenna return loss and efficiency are measured in a reverberation chamber. From these results, the EBG substrate demonstrates 60% improvement of the antenna efficiency compared to other methods in the wearable antenna scenario.
MPSA 2004 Final Report (2006)

This proposal was to support a portion of the costs of Methods in Protein Structure Analysis 2004 (MPSA2004). MPSA2004 was the 15th in the series of MPSA international conferences on protein structure analysis that began in 1974. MPSA2004 was held on the campus of the University of Washington, Seattle, WA August 29 through September 2, 2004. Twenty-four internationally recognized speakers gave invited presentations; additional participants were chosen to present short talks in the 10 topics that were addressed. The aim of MPSA conferences is to communicate the latest, cutting-edge techniques in protein structure analysis and proteomics through science success stories as told by the scientific leaders who developed the technologies. Biotechnology vendors are present to explain currently available commercial technology through workshops and demonstrations booths. The overall aim is to provide a forum for exchanging the latest methods and ideas in protein structure analysis and proteomics to current and future practitioners. The conference supported the missions of the DOE Office of Science and the Office of Biological and Environmental Research (BER) in at least two ways: by enabling the above forum, and by encouraging young researchers who might otherwise not attend to meet leading researchers and to learn about the most current ideas, technologies, products, and services relevant to protein structure analysis. Topics covered in MPSA2004 were highly relevant to the BER Genomics: GTL initiative and several National Laboratory scientists were among the invited speakers.
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility (2008)

Integrin binding to matrix proteins such as fibronectin (FN) leads to formation of focal adhesion (FA) cellular contact sites that regulate migration. RhoA GTPases facilitate FA formation, yet FA-associated RhoA-specific guanine nucleotide exchange factors (GEFs) remain unknown. Here, we show that proline-rich kinase-2 (Pyk2) levels increase upon loss of focal adhesion kinase (FAK) in mouse embryonic fibroblasts (MEFs). Additionally, we demonstrate that Pyk2 facilitates deregulated RhoA activation, elevated FA formation, and enhanced cell proliferation by promoting p190RhoGEF expression. In normal MEFs, p190RhoGEF knockdown inhibits FN-associated RhoA activation, FA formation, and cell migration. Knockdown of p190RhoGEF-related GEFH1 does not affect FA formation in FAK(-/-) or normal MEFs. p190RhoGEF overexpression enhances RhoA activation and FA formation in MEFs dependent on FAK binding and associated with p190RhoGEF FA recruitment and tyrosine phosphorylation. These studies elucidate a compensatory function for Pyk2 upon FAK loss and identify the FAK-p190RhoGEF complex as an important integrin-proximal regulator of FA formation during FN-stimulated cell motility.
Generalized Dix equation and analytic treatment of normal‐moveout velocity for anisotropic media* (1999)

Despite the complexity of wave propagation in anisotropic media, reflection moveout on conventional common‐midpoint (CMP) spreads is usually well described by the normal‐moveout (NMO) velocity defined in the zero‐offset limit. In their recent work, Grechka and Tsvankin showed that the azimuthal variation of NMO velocity around a fixed CMP location generally has an elliptical form (i.e. plotting the NMO velocity in each azimuthal direction produces an ellipse) and is determined by the spatial derivatives of the slowness vector evaluated at the CMP location. This formalism is used here to develop exact solutions for the NMO velocity in anisotropic media of arbitrary symmetry. For the model of a single homogeneous layer above a dipping reflector, we obtain an explicit NMO expression valid for all pure modes and any orientation of the CMP line with respect to the reflector strike. The contribution of anisotropy to NMO velocity is contained in the slowness components of the zero‐offset ray (along with the derivatives of the vertical slowness with respect to the horizontal slownesses) — quantities that can be found in a straightforward way from the Christoffel equation. If the medium above a dipping reflector is horizontally stratified, the effective NMO velocity is determined through a Dix‐type average of the matrices responsible for the ‘interval’ NMO ellipses in the individual layers. This generalized Dix equation provides an analytic basis for moveout inversion in vertically inhomogeneous, arbitrarily anisotropic media. For models with a throughgoing vertical symmetry plane (i.e. if the dip plane of the reflector coincides with a symmetry plane of the overburden), the semi‐axes of the NMO ellipse are found by the more conventional rms averaging of the interval NMO velocities in the dip and strike directions. Modelling of normal moveout in general heterogeneous anisotropic media requires dynamic ray tracing of only one (zero‐offset) ray. Remarkably, the expressions for geometrical spreading along the zero‐offset ray contain all the components necessary to build the NMO ellipse. This method is orders of magnitude faster than multi‐azimuth, multi‐offset ray tracing and, therefore, can be used efficiently in traveltime inversion and in devising fast dip‐moveout (DMO) processing algorithms for anisotropic media. This technique becomes especially efficient if the model consists of homogeneous layers or blocks separated by smooth interfaces. The high accuracy of our NMO expressions is illustrated by comparison with ray‐traced reflection traveltimes in piecewise‐homogeneous, azimuthally anisotropic models. We also apply the generalized Dix equation to field data collected over a fractured reservoir and show that P‐wave moveout can be used to find the depth‐dependent fracture orientation and to evaluate the magnitude of azimuthal anisotropy.
Synthetic Glycerides. IV. Esters of Aromatic and Aliphatic Acids (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic Glycerides. IV. Esters of Aromatic and Aliphatic AcidsDonald T. Jackson and C. G. KingCite this: J. Am. Chem. Soc. 1933, 55, 2, 678–680Publication Date (Print):February 1, 1933Publication History Published online1 May 2002Published inissue 1 February 1933https://pubs.acs.org/doi/10.1021/ja01329a032https://doi.org/10.1021/ja01329a032research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structure of stacking faults formed during the forward bias of 4H-SiC p-i-n diodes (2003)

Using site-specific plan-view transmission electron microscopy (TEM) and light emission imaging, we have identified stacking faults formed during forward biasing of 4H-SiC p-i-n diodes. These stacking faults (SFs) are bounded by Shockley partial dislocations and are formed by shear strain rather than by the condensation of vacancies or interstitials. Detailed analysis using TEM diffraction contrast experiments reveal SFs with leading carbon-core Shockley partial dislocations as well as with the silicon-core partial dislocations observed in plastic deformation of 4H-SiC at elevated temperatures. The leading Shockley partials are seen to relieve both tensile and compressive strain during p-i-n diode operation, suggesting the presence of a complex inhomogeneous strain field in the 4H-SiC layer.
Dry Cow Therapy: Effects of Method of Drug Administration on Occurrence of Intramammary Infection (1986)

Two methods of administering a dry cow infusion product were evaluated: 1) full insertion of infusion cannula into the teat cistern, and 2) partial insertion of infusion cannula into the teat canal. Eighty-six Jersey cows were treated at dry off; two quarters of each cow were infused using method 1, and two quarters were infused using method 2. The new quarter infection rate for method 1 with major intramammary pathogens was 9.9% (17 infections/172 quarters); that for method 2 was 4.1% (7 infections/171 quarters). Treatment efficacies against major pathogens for methods 1 and 2, were 57.9% (11 cures/19 quarters) and 85.7% (12 cures/14 quarters), respectively.
Gut inflammation and dysbiosis in human motor neuron disease (2017)

Amyotrophic lateral sclerosis (ALS) is a systemic disorder that involves dysfunction of multiple organs. Growing evidence has shown that neurodegenerative disorders with gut dysbiosis affect the central nervous system via pro-inflammatory mediators thus impacting gut-brain communications. We have demonstrated dysbiosis and increased intestinal permeability in the SOD1<sup>G93A</sup> ALS mouse model. In this study, we comprehensively examined the human gut microbiome in stool samples and evaluated infection and markers of intestinal inflammation in five patients with ALS and motor neuron disorders. Five patients we studied all had alteration in their gut microbiome characterized by a low diversity of the microbiome, compared to healthy cohorts with relatively intact abundance. <i>Firmicutes</i> and <i>Bacteroidetes are</i> the two major members of bacteria at the phylum level. Low <i>Ruminococcus spp</i> occurred in three patients with low <i>Firmicutes</i>/<i>Bacteroidetes</i> (F/B) ratio. A majority of patients had signs of intestinal inflammation. This is the first comprehensive examination of inflammatory markers in the stool of ALS patients. Studies in gut health and microbiome related to the onset and progression of ALS may reveal novel therapeutic targets for disease modulation.
Smoking-Associated Mitochondrial DNA Mutations and Lipid Peroxidation in Human Lung Tissues (1998)

To investigate the effect of cigarette smoking on mitochondrial DNA (mtDNA) mutation and lipid peroxidation in lung tissues, 152 samples from lung resections were collected. A novel deletion of 4,839 bp of mtDNA was found in 80 (52.6%) of the 152 lung samples. The breakpoints of the 4,839-bp mtDNA deletion were flanked by a nine-nucleotide direct repeat (5'-CATACACAA-3'). The frequency of occurrence and the proportion of the 4,839-bp mtDNA deletion in the lung increased significantly with the smoking index in terms of pack-years (P < 0.05). The incidence and proportion of the 4,839-bp mtDNA deletion in the lung tissues of current smokers were significantly higher than in those of nonsmokers (P < 0.05). In addition, we found that the content of lipid peroxides in the lung tissues of the smokers was significantly higher than in that of nonsmokers, and increased with the smoking index. The average malondialdehyde level in the lung tissues was 12.81 +/- 4.99 micromol/g for subjects with a smoking index of more than 50 pack-yr, and was 5.39 +/- 0.48 micromol/g for nonsmokers (P < 0.05). Multiple regression analysis showed that the smoking index, tissue lipid-peroxide content, and FEV1/FVC ratio were correlated with the proportion of the 4,839-bp mtDNA deletion in the lung. These results suggest that cigarette smoke plays an important role in the increase in mtDNA mutation and lipid peroxidation in the lung tissues of smokers.
Understanding Performance of Edge Content Caching for Mobile Video Streaming (2017)

Today's Internet has witnessed an increase in the popularity of mobile video streaming, which is expected to exceed 3/4 of the global mobile data traffic by 2019. To satisfy the considerable amount of mobile video requests, video service providers have been pushing their content delivery infrastructure to edge networks-from regional content delivery network (CDN) servers to peer CDN servers (e.g., smartrouters in users' homes)-to cache content and serve users with storage and network resources nearby. Among the edge network content caching paradigms, Wi-Fi access point caching and cellular base station caching have become two mainstream solutions. Thus, understanding the effectiveness and performance of these solutions for large-scale mobile video delivery is important. However, the characteristics and request patterns of mobile video streaming are unclear in practical wireless network. In this paper, we use real-world data sets containing 50 million trace items of nearly 2 million users viewing more than 0.3 million unique videos using mobile devices in a metropolis in China over two weeks, not only to understand the request patterns and user behaviors in mobile video streaming, but also to evaluate the effectiveness of Wi-Fi and cellular-based edge content caching solutions. To understand the performance of edge content caching for mobile video streaming, we first present temporal and spatial video request patterns, and we analyze their impacts on caching performance using frequency-domain and entropy analysis approaches. We then study the behaviors of mobile video users, including their mobility and geographical migration behaviors, which determine the request patterns. Using trace-driven experiments, we compare strategies for edge content caching, including least recently used (LRU) and least frequently used (LFU), in terms of supporting mobile video requests. We reveal that content, location, and mobility factors all affect edge content caching performance. Moreover, we design an efficient caching strategy based on the measurement insights and experimentally evaluate its performance. The results show that our design significantly improves the cache hit rate by up to 30% compared with LRU/LFU.