gebhart/patrepeval huggingface dataset:
Preparation and adsorption properties for metal ions of chitin modified by <scp>L</scp>‐cysteine (2003)

Abstract A new adsorbent for heavy metal ions, cys‐chitin, was produced by modifying chitin in THF with L ‐cysteine in the presence of sulfuric acid as a catalyst. Its structure was confirmed by elemental analysis and FTIR spectra analysis. The adsorption properties of cys‐chitin for Cu II , Cd II , Pb II , Zn II , and Ni II were investigated. The effect of pH value on adsorption and adsorption kinetics was examined. The results indicate that the cys‐chitin has much better adsorption for Cd II , Pb II , and Zn II than chitin itself. The adsorption capacities of cys‐chitin for Cd II , Pb II , and Zn II were 214.6, 351.5, and 107.0 mg/g, respectively. It also had good adsorption properties for heavy metal ions. The adsorption capacities were also affected by the acidity of medium. The adsorbed Cd II , Pb II could be eluted by diluted nitric acid. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 2575–2579, 2003
Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients. (1996)

This report concerns the evaluation of various estrogens, estrone (El), estradiol (E2), and estrone sulfate (E1S), as well as E1S-sulfatase and aromatase activities in pre- and postmenopausal women with breast cancer. The levels (in picomoles per g; mean +/- SEM) of the various estrogens in the breast tissue from premenopausal patients (n = 11) are: El, 1.4 +/- 0.5; E2, 1.2 +/- 0.6; and E1S, 1.2 +/- 0.3. In postmenopausal patients (n = 23), the values are, respectively, 1.0 +/- 0.4, 1.4 +/- 0.7, and 3.3 +/- 1.9. These concentrations of estrogens in the tumors of postmenopausal patients are significantly higher than those found in plasma. The activity of E1S-sulfatase in both pre- and postmenopausal patients was 50-200 times higher than that of aromatase. E1S-sulfatase and aromatase activities are significantly higher in post-menopausal than in cycling patients. It is concluded that despite the low levels of circulating estrogens in postmenopausal patients, the tissue concentrations of these steroids are several-fold higher than those in plasma, suggesting tumor accumulation of these estrogens. The physiopathology and clinical significance of these high levels of the various estrogens (E1, E2, and E1S) as well as sulfatase and aromatase activities in postmenopausal patients with breast cancer is yet to be explored.
An overview on anti-inflammatory properties and chemo-profiles of plants used in traditional medicine (2010)

Plant drugs have been the major source for treatment of diseases for a long time. They have been used in traditional medicine on the basis of experiences and practice. With the advent of modern systems of medicine need has been felt to investigate the active constituents present in these plants. Various molecules have been isolated, characterized and tested for their related pharmacological activities. The active molecules have provided significant leads in the development of more effective synthetic molecules. Inflammation is the major condition associated with various diseases. Rheumatoid arthritis is one of the challenging disorders associated with inflammatory conditions. Various molecules have been isolated from plant drugs which have been proven very effective in such conditions. For example: a potent anti-inflammatory analgesic molecule Aspirin was developed from Salicin, a compound isolated from bark of Salix alba Linn. This paper provides an overview on the recent findings on some plants having anti-inflammatory activity and chemical constituents isolated from them.
Application of telomerase assay for the screening of cervical lesions. (1997)

Telomerase is a ribonucleoprotein that synthesizes telomeric DNA onto chromosomal ends. The expression of telomerase is thought to be required for cellular immortality and oncogenesis. Telomerase activity has been detected not only in most cancers but also in some types of premalignant lesions, such as squamous intraepithelial lesions (SILs). In the present study, we used the telomerase assay to detect uterine cervical lesions in cervical scraping samples. A total of 82 cervical scraping samples were obtained from women with or without cervical lesions and examined by nonradioisotope telomeric repeat amplification protocol assay. Fifteen of 17 (88%) cervical cancer specimens exhibited telomerase activity, whereas 5 of 8 (63%) and 14 of 24 (58%) specimens from low-grade and high-grade SILs, respectively, also exhibited telomerase activity. In contrast, 3 of 33 (9%) specimens from normal cervices exhibited telomerase activity. Dilution telomeric repeat amplification protocol assay was performed to estimate telomerase activity; it revealed that high levels of activity were often expressed in cervical cancer. Cytological examination was also performed by Pap smear test, and 4 of 8 (50%) low-grade SILs, 21 of 24 (88%) high-grade SILs, and 16 of 17 (94%) cervical cancers were found to have cytological abnormalities. There were discordances in some cases between findings of smear abnormality and telomerase positivity. In particular, we found five cases of SILs without smear abnormality but with telomerase activity, suggesting that some lesions with false negative cytology can be detected by telomerase assay. These findings suggest that telomerase assay using cervical scrapings might be a useful screening method for cervical lesions especially when combined with a Pap smear test.
Reproductive Malformation of the Male Offspring Following Maternal Exposure to Estrogenic Chemicals (2000)

Recently, significant concerns have been placed on the widespread use of chemicals with persistent estrogenic activity for their long-term effects on human health. In this communication, we investigated whether fetal exposure to some of these chemicals at doses consumed by people, has any long-term effect on the reproductive functions of the male offspring. Thus, time-pregnant CD-1 mice were fed diethylstilbestrol (DES), bisphenol A (BPA), and aroclor (aroclor 1016) at an average concentration of 100 ng/kg/day, 50 microg/kg/day, and 50 microg/kg/day, respectively, during Days 16-18 of gestation. A high dose of DES (200 microg/kg/day) was also tested to compare the results of the current study with those of others using the high dose only. The offspring were examined at Day 3, Day 21, and Day 60 following birth. We demonstrated that BPA, aroclor, and the lower dose of DES enhanced anogenital distance, increased prostate size, and decreased epididymal weight. No effect was found on the testicular weight or size. The chemicals also permanently increased androgen receptor (AR) binding activity of the prostate at this dosage. This is the first demonstration that environmental chemicals program AR function permanently at the dosage consumed by the general population. The higher dosage of DES, on the other hand, produced an opposite effect, decreasing prostate weight, prostate AR binding, and anogenital distance, thus confirming the previous reports. To investigate whether the above mentioned effects of the chemicals represent direct or indirect effects, we also tested the effect of the chemicals on prostate development in vitro. Thus fetal urogenital sinus (UGS), isolated at the 17th day of gestation was cultured with the chemicals in the presence and absence of testosterone (10 ng/ml) for 6 days, and prostate growth was monitored by determining the size and branching of the specimen following histology. Results showed that these chemicals induced prostate growth in the presence and absence of testosterone. They also increased androgen-binding activity. Thus, the results of the in vivo studies were reproduced in the in vitro experiments, suggesting a direct effect of these chemicals on the development of fetal reproductive organs. This is the first demonstration that estrogenic chemicals induce reproductive malformation by direct interference with the fetal reproductive organs and not by interfering with the maternal or fetal endocrine system. The chemicals are able to induce malformation even in the absence of fetal testosterone; however, they are more effective in the presence of testosterone.
Stem Cells in Cardiac Repair (2010)

Myocardial infarction is the leading cause of death among people in industrialized nations. Although the heart has some ability to regenerate after infarction, myocardial restoration is inadequate. Consequently, investigators are currently exploring the use of human embryonic stem cells (hESCs), skeletal myoblasts and adult bone marrow stem cells to limit infarct size. hESCs are pluripotent cells that can regenerate myocardium in infarcted hearts, attenuate heart remodeling and contribute to left ventricle (LV) systolic force development. Since hESCs can form heart teratomas, investigators are differentiating hESCs toward cardiac progenitor cells prior to transplantation into hearts. Large quantities of hESCs cardiac progenitor cells, however, must be generated, immune rejection must be prevented and grafts must survive over the long term to significantly improve myocardial performance. Transplanted autologous skeletal myoblasts can survive in infarcted myocardium in small numbers, proliferate, differentiate into skeletal myofibers and increase the LV ejection fraction. These cells, however, do not form electromechanical connections with host cardiomyocytes. Consequently, electrical re-entry can occur and cause cardiac arrhythmias. Autologous bone marrow mononuclear cells contain hematopoietic and mesenchymal stem cells. In several meta-analyses, patients with coronary disease who received autologous bone marrow cells by intracoronary injection show significant 3.7% (range: 1.9-5.4%) increases in LV ejection fraction, decreases in LV end-systolic volume of -4.8 ml (range: -1.4 to -8.2 ml) and reductions in infarct size of 5.5% (-1.9 to -9.1%), without experiencing arrhythmias. Bone marrow cells appear to release biologically active factors that limit myocardial damage. Unfortunately, bone marrow cells from patients with chronic diseases propagate poorly and can die prematurely. Substantial challenges must be addressed and resolved to advance the use of stem cells in cardiac repair including identifying the optimal stem cell(s) that permit transplantation without requirements for host immune suppression; timing of stem cell transplantation that maximizes chemoattraction of stem cells to infarcts; and determining the optimal technique for injecting stem cells for cardiac repair. Techniques must be developed to enhance survival and propagation of stem cells in the myocardium. These studies will require close cooperation and interaction of scientists and clinicians. Cell-based cardiac repair in the 21st century will offer new hope for millions of patients worldwide with myocardial infarctions who, otherwise, would suffer from the relentless progression of heart disease to heart failure and death.
Data access architecture in object oriented applications using design patterns (2004)

This paper describes the data access architecture in a modern object-oriented application. Complex application solutions have multiple, parallel data sources. Each data source has many specific properties and ways for data access. This architecture, by using the already tried solutions, ensures a simple and flexible way to access the different data sources. It also describes the singleton, data access object and abstract the factory patterns and their interaction in achieving the flexible and scalable data access architecture.
Trajectory prediction in cluttered voxel environments (2010)

Trajectory planning and optimization is a fundamental problem in articulated robotics. It is often viewed as a two phase problem of initial feasible path planning around obstacles and subsequent optimization of a trajectory satisfying dynamical constraints. There are many methods that can generate good movements when given enough time, but planning for high-dimensional robot configuration spaces in realistic environments with many objects in real time remains challenging. This work presents a novel way for faster movement planning in such environments by predicting good path initializations. We build on our previous work on trajectory prediction by adapting it to environments modeled with voxel grids and defining a frame invariant prototype trajectory space. The constructed representations can generalize to a wide range of situations, allowing to predict good movement trajectories and speed up convergence of robot motion planning. An empirical comparison of the effect on planning movements with a combination of different trajectory initializations and local planners is presented and tested on a Schunk arm manipulation platform with laser sensors in simulation and hardware.
ChemInform Abstract: Identification of a Selective Small Molecule Inhibitor of Breast Cancer Stem Cells. (2012)

Abstract A class of acyl hydrazones is identified by a high‐throughput screen (HTS) to be selectively lethal to breast cancer stem cell (CSC) enriched populations.
Boron-based small molecules in disease detection and treatment (2013–2016) (2017)

Abstract Recent years have seen tremendous development in the design and synthesis of boron-based compounds as potential therapeutics and for detection applications. The present review highlights the most recent development of these boron-based small molecules, covering clinically used ixazomib, tavaborole, crisaborole and other molecules from 2013 to 2016.
Hydride, alkyl, and alyl complexes of bis(.pi.-cyclopentadienyl)thitanium(III) (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydride, alkyl, and alyl complexes of bis(.pi.-cyclopentadienyl)thitanium(III)Hans. BrintzingerCite this: J. Am. Chem. Soc. 1967, 89, 26, 6871–6877Publication Date (Print):December 1, 1967Publication History Published online1 May 2002Published inissue 1 December 1967https://pubs.acs.org/doi/10.1021/ja01002a011https://doi.org/10.1021/ja01002a011research-articleACS PublicationsRequest reuse permissionsArticle Views414Altmetric-Citations125LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SAW-Less Analog Front-End Receivers for TDD and FDD (2013)

A multistandard SAW-less receiver is designed exploring a current-mode architecture. A class-AB common-gate transformer-based low-noise transconductor amplifier (LNTA) is used to provide high linearity and harmonic filtering. A resonant passive mixer is adopted in order to allow the current-mode operation and improve the harmonic rejection. A low-power divider with intrinsic 25% duty-cycle is introduced to drive the passive mixer. A second-order Rauch biquad with complex poles makes-up the IQ blocker tolerant baseband. The receiver is designed to be suitable for SAW-less TDD and typical FDD applications with 3.8 and 1.9 dB of NF and > 18 and > 16 dBm of IIP3, respectively, using only 32 mW for each receiver.
Results of Periprosthetic Hip and Knee Infections Caused by Resistant Bacteria (2002)

Seventy patients with deep periprosthetic hip or knee infections were treated between May 1997 and March 2001. Thirty-five patients had periprosthetic infections of their total hip arthroplasties and 35 patients had periprosthetic infections of their total knee arthroplasties. The patients were subdivided into two subgroups: patients who had infections with Staphylococcal bacterial strains that were sensitive to methicillin and patients who had infections with bacteria that were resistant to methicillin (methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis). Treatment was considered successful if the patient was able to retain his or her hip or knee prosthesis either as a result of irrigation and debridement procedures alone or after excision of the infected total hip or knee prosthesis followed by successful reimplantation. Treatment was considered a failure if the patient eventually required arthrodesis, amputation, or was left with a permanent excision arthroplasty. Hip replacements that were infected with antibiotic-sensitive bacteria were treated successfully in 81% of cases. In contrast, hip replacements infected with resistant organisms were treated successfully in only 48% of cases. Similarly, knee replacements infected with sensitive organisms had a success rate of 89%, compared with only 18% of the total knee replacements that were infected with resistant bacterial strains.
RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery (2019)

Our results, which outline a robust FFPE-RNA-seq pipeline for broad use, support utilizing FFPE tissues to address key questions in the breast cancer field, including the delineation between indolent and life-threatening disease, biological stratification and molecular mechanisms of treatment resistance.
Dual-Band Circularly Polarized Shared-Aperture Array for $C$ -/ $X$ -Band Satellite Communications (2017)

A novel method of achieving a single-feed circularly polarized (CP) microstrip antenna with both broad impedance bandwidth and axial ratio (AR) bandwidth is presented. The CP characteristics are generated by employing a resonator to excite the two orthogonal modes of the patch via two coupling paths and the required 90° phase difference is achieved by using the different orders of the two paths. The presented method, instead of conventional methods that power dividers and phase delay lines are usually required, not only significantly enhances the bandwidths of the antenna but also results in a compact feed, reduced loss and high gain. Based on this method, a dual-band shared-aperture CP array antenna is implemented for C-/X-band satellite communications. The antenna aperture includes a 2 × 2 array at C-band and a 4 × 4 array at X-band. To accommodate the C-X-band elements into the same aperture while achieving a good isolation between them, the C-band circular patches are etched at the four corners. The measured results agree well with the simulations, showing a wide impedance bandwidth of 21% and 21.2% at C-band and X-band, respectively. The C-band and X-band 3 dB AR bandwidths are 13.2% and 12.8%. The array also exhibits a high aperture efficiency of over 55%, low sidelobe (C-band: -12.5 dB and X-band: -15 dB), and high gain (C-band: 14.5 dBic and X-band: 17.5 dBic).
A peptidoglycan hydrolase similar to bacteriophage endolysins acts as an autolysin in <i>Neisseria gonorrhoeae</i> (1997)

We have identified a gene encoding an autolysin (atlA) from Neisseria gonorrhoeae. The deduced amino acid sequence of AtlA shows significant similarity to the peptidoglycan degrading transglycosylases (endolysins) of bacteriophages lambda and P2, suggesting that the encoded protein also functions in peptidoglycan hydrolysis. An atlA mutant was identical to the wild-type strain in exponential growth rate, but demonstrated reduced lysis and peptidoglycan turnover in the stationary phase of growth. When transferred into a buffer solution, at a pH non-permissive for other gonococcal autolysins, an autolytic activity was detectable in the wild-type strain that was not present in the mutant. The most dramatic phenotype of the mutant occurred after extended time in stationary phase. After approximately 16h in stationary phase, both strains underwent an apparent replication event, after which the wild-type strain died rapidly whereas the atlA mutant survived considerably longer. Even after both the wild-type and mutant cells were dead, many of the mutant cells maintained intact morphology, whereas the wild-type cells were lysed. These results suggest that AtlA is a peptidoglycan transglycosylase related to bacteriophage endolysins and acts as an autolysin in the stationary phase.
Ejectors for Boosting Low-Pressure Oil Wells (1999)

Summary The first field installation of a multiphase surface ejector was successfully accomplished in the Villafortuna oilfield (Italy) in 1996. The ejector increased the oil production rate by 30% and demonstrated the viability ofthe system as a reliable low cost-small size boosting system that had minimal impact on existing facilities, and is suitable for applications in existing fields or for new development both onshore and offshore. The article describes the main steps ofthe R&D project, developed in collaboration with the University of Ancona, as well as the testing process in which different ejector geometries were extensively tested with crude oil and gas in the Agip's multiphase loop of Trecate. The article describes the installation in the Villafortuna field as well as other studies under development.
A cellular form of prion protein (PrPC) exists in many non-neuronal tissues of sheep (1995)

A cellular form of the prion protein (PrPC) is thought to be a substrate for an abnormal isoform of th eprion protein (PrPSc) in scrapie. PrPC is abundant in tissues of the central nervous system, but little is known about the distribution of PrPC in non-neuronal tissues of sheep, the natural host of scrapie. This study investigated the tissue distribution of PrPC in sheep. Although PrPC was abundant in neuronal tissues, it was detected in non-neuronal tissues such as spleen, lymph node, lung, heart, kidney, skeletal muscle, uterus, adrenal gland, parotid gland, intestine, proventriculus, abomasum and mammary gland. Neither PrPC nor PrP mRNA was detected in the liver. The tissue distribution of PrPC appears to be inconsistent with the tissues which possess scrapie infectivity, suggesting that factor(s) specific to certain cell types may be required to support multiplication of the scrapie agent.
Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract (1998)

Extracellular glutathione peroxidase (EGPx) is a glycosylated selenoprotein capable of reducing hydrogen peroxide, organic hydroperoxides, free fatty acid hydroperoxides, and phosphatidylcholine hydroperoxides. We found that human large intestinal explant cultures synthesize EGPx and cellular glutathione peroxidase (CGPx) and secrete EGPx. The level of EGPx mRNA expression relative to alpha-tubulin was similar throughout the mouse gastrointestinal tract. EGPx mRNA transcripts have been localized to mature absorptive epithelial cells in human and mouse large intestine. Western blot analysis of mouse intestinal protein has demonstrated the presence of EGPx protein in the small intestine, cecum, and large intestine, with the highest protein levels found in the cecum. Immunohistochemistry studies of human large intestine and mouse small and large intestine sections demonstrated the presence of EGPx protein within mature absorptive epithelial cells. In human large intestine and mouse small intestine, EGPx protein is also present in the extracellular milieu. These results suggest a role for EGPx in protection of the intestinal tract from peroxidative damage and/or in intercellular metabolism of peroxides.