gebhart/patrepeval huggingface dataset:
Translocations Involving MUM1 are Rare in Diffuse Large B-cell Lymphoma (2010)

Diffuse large B-cell lymphoma (DLBCL) comprises a diverse group of neoplasms that have recently been subdivided by gene expression profiling and immunohistochemical studies into at least 2 subgroups [germinal center (GC) type and non-GC type]. The non-GC subtype has a post-GC activated phenotype and typically expresses MUM1 by immunohistochemistry. We hypothesized that MUM1 may be dysregulated/up-regulated in these tumors by a chromosomal translocation, as is seen in many cases of plasma cell myeloma [where MUM1 is juxtaposed with the immunoglobulin heavy chain gene (IgH)]. Therefore, using a novel MUM1 break-apart probe constructed in our laboratory, we performed fluorescence in situ hybridization on 33 cases of DLBCL (17 GC type and 16 non-GC type) for a MUM1 translocation. We identified 1 case of a MUM1 translocation out of 31 cases with successful fluorescence in situ hybridization. This case was a non-GC DLBCL (1/15). We conclude that genetic abnormalities involving MUM1 are rare in DLBCL and that a mechanism of deregulation of the MUM1 protein other than by a translocation event is involved in the majority of non-GC cases.
ChemInform Abstract: A New Combined Purification/Phosphorylation Procedure for Oligodeoxynucleotides. (1990)

Abstract The phosphoramidite (I) is synthesized, which allows the introduction of a purification handle into synthetic oligodeoxynucleotides during their synthesis on a solid support and proves to be useful in a simple purification procedure for oligodeoxynucleotides.
Effect of Intermittent Cold Exposure on Brown Fat Activation, Obesity, and Energy Homeostasis in Mice (2014)

Homeotherms have specific mechanisms to maintain a constant core body temperature despite changes in thermal environment, food supply, and metabolic demand. Brown adipose tissue, the principal thermogenic organ, quickly and efficiently increases heat production by dissipating the mitochondrial proton motive force. It has been suggested that activation of brown fat, via either environmental (i.e. cold exposure) or pharmacologic means, could be used to increase metabolic rate and thus reduce body weight. Here we assess the effects of intermittent cold exposure (4°C for one to eight hours three times a week) on C57BL/6J mice fed a high fat diet. Cold exposure increased metabolic rate approximately two-fold during the challenge and activated brown fat. In response, food intake increased to compensate fully for the increased energy expenditure; thus, the mice showed no reduction in body weight or adiposity. Despite the unchanged adiposity, the cold-treated mice showed transient improvements in glucose homeostasis. Administration of the cannabinoid receptor-1 inverse agonist AM251 caused weight loss and improvements in glucose homeostasis, but showed no further improvements when combined with cold exposure. These data suggest that intermittent cold exposure causes transient, meaningful improvements in glucose homeostasis, but without synergy when combined with AM251. Since energy expenditure is significantly increased during cold exposure, a drug that dissociates food intake from metabolic demand during cold exposure may achieve weight loss and further metabolic improvements.
Preparation and Characteristics of Conducting Polymer-Coated MWCNTs as Electromagnetic Interference Shielding Materials (2011)

The conducting polymer-coated multi-walled carbon nanotubes (MWCNTs) were prepared by template polymerization of aniline and pyrrole on the surface of MWCNTs in order to develop the novel electromagnetic interference (EMI) shielding materials. The conducting polymer phases formed on the surface of MWCNTs were confirmed by field emission-scanning electron microscopy and field emission-transmission electron microscopy. Both permittivity and permeability were significantly improved for the conducting polymer-coated MWCNTs due to the intrinsic electrical properties of MWCNTs and the conducting properties of coated polymers. The electromagnetic waves were effectively absorbed based on the permittivity nature of conducting polymer and MWCNTs preventing the secondary interference from reflecting the electromagnetic waves. The highly improved EMI shielding efficiency was also obtained for the conducting polymer-coated MWCNTs showing the synergistic effects by combining MWCNTs and the conducting polymers.
Critical appraisal of the evidence for tributyltin-mediated endocrine disruption in mollusks (1998)

Abstract This article reviews the field and laboratory evidence for endocrine disruption in gastropod mollusks caused by tributyltin (TBT). Abundant and undisputed field data link TBT with an irreversible sexual abnormality of female neogastropod snails known as “imposex.” This phenomenon is a masculinization process involving the development of male sex organs, notably a penis and a vas deferens; in certain species the imposition of a vas deferens disrupts oviducal structure and function, preventing normal breeding activity and causing population disappearance. In some species, oogenesis is supplanted by spermatogenesis. A related condition referred to as “intersex” has been reported in littorinid mesogastropods, and these too become unable to lay eggs. Field evidence clearly associates these syndromes with the use of TBT as an antifoulant, chiefly on boat hulls, and dose-related effects can be replicated in laboratory exposures to environmentally relevant concentrations of TBT compounds. It has now been established that imposex and intersex are forms of endocrine disruption caused by elevated testosterone titers that masculinize TBT-exposed females. The precise mechanism by which increased levels of testosterone are produced has not been fully described, but the weight of evidence suggests that TBT acts as a competitive inhibitor of cytochrome P450-mediated aromatase. Some recent data suggest that TBT may also inhibit the formation of sulfur conjugates of testosterone and its active metabolites, thus interfering with its excretion. In summary, TBT-induced masculinization in gastropods, imposex and intersex, is the clearest example of endocrine disruption described in invertebrates to date that is unequivocally linked to a specific environmental pollutant.
Preeclampsia Rates in the United States, 1980 to 2010 (2014)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious Issues Collections Obstetric Airway ManagementMaternal EmbolismRegional Anesthesia for Cesarean SectionGeneral Anesthesia for Cesarean SectionAnalgesia for LaborObstetric HemorrhagePre-Eclampsia/EclampsiaPharmacologyTraumaInfection and SepsisMaternal ObesityMaternl Morbidity and MortalityNeonatal Morbidity and MortalityObstetric ComplicationsAnesthetic ComplicationsNon-Obstetric Maternal DiseaseCritical CareDrug Abuse in PregnancyEthicsSystems Based Practice For Authors Information for AuthorsLanguage Editing ServicesLippincott® Preprints Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Dexamethasone Attenuates Staphylococcal Enterotoxin B-Induced Hypothermic Response and Protects Mice from Superantigen-Induced Toxic Shock (2005)

The superantigenic staphylococcal enterotoxins are important virulence factors and contribute to various diseases, including food poisoning and toxic shock. Dexamethasone, an anti-inflammatory agent, attenuated staphylococcal enterotoxin B (SEB)-induced hypothermia and serum proinflammatory cytokines and improved survival from 0% to 86% in a lethal mouse model of SEB-mediated shock.
ALIPHATIC CHEMISTRY OF FLUORENE:PART IV. PREPARATION AND ALKYLATION OF SOME SULPHIDES AND SULPHONES (1960)

The preparations are described of some 9-fluorenyl sulphides which have been oxidized with peracetic acid to the corresponding sulphones.9-Fluorenyl p-tolyl sulphone has been alkylated with a range of alkyl halides; other sulphones, including 2-nitro-9-fluorenyl p-tolyl sulphone, have been methylated.Methyl fluorene-9-carboxylate anion was reduced by p-toluenesulphonyl chloride to dimethyl 9,9′-difluorenyl-9,9′-dicarboxylate.
Production and Properties of Carbide Dispersion-strengthened Coppers by Compocasting. (1991)

An investigation was made on the electrical and mechanical properties of ~ispersion-Strengthened (DS) coppers compocast at 25 revlsec with the addition of fine carbide particles in the range of 0.5 to 30 masso/o WC. TaC. VC. TiC. NbC. ZrC. M02C.Cr3C2and Al4C3' Homogeneous dispersion of carbides was observed in the microstructures of the compocastDScoppers except with the addition of M02C.Cr3C2Or Al4C3' The measuredvalues of electrical conductivity of the DScoppers were 77.90/01ACSat 20 masso/o WC. 73.40/01ACS at 20 masso/o TaC, 72.00/01ACSat 10masso/o NbC, 85.20/01ACSat 5masso/o TiC and 68.90/01ACSat 5 masso/o VC. The values of Vickers ha!dness were HV197 at 30 masso/o WC.HV155 at 30masso/o NbC. HV110 at 30 masso/o TaC. HV158 at 20 masso/o VCand HV1 21 at 20 masso/o TiC. Ultimate tensile strength values were 402 MPa at 30 masso/o NbC, 357 MPa at 20 masso/o TiC, 330 MPa at 20 masso/o WC,269 MPa at 20 masso/o TaCand 323 MPa at 10masso/o VC. The values of elongation were 12.90/0 at 20masso/o TaC. 10 .90/0 at 20 masso/o WC, 25.20/0 at IO masso/o NbC, 21 .80/0 at I O masso/o VCand 1 7.50/0 at 5 masso/o TiC.
[Comparison of shape recovery ratios in various IOL haptics]. (1991)

We examined shape recovery ratios of various IOL haptics (polypropylene, polyvinylidene fluoride, polymethylmethacrylate) under conditions resembling clinical use. Experiments were carried out using Ascon lens-holding forceps and compression tests in cylindrical holders. The experimental results indicated that PVDF haptics were superior to PP and 3-piece PMMA haptics. This would suggest the need for surgeons to establish safer implantation techniques in the future by taking into consideration the shape recovery characteristics of the haptics involved. At the same time, further research and development of haptic materials is required by manufacturers.
A radiation-hard phase-locked loop (2004)

Phase-locked loops (PLLs) are often used as frequency multiplier for generating high frequency clock signals. In space application, however, performance of the normal PLL is degraded due to the radiation effects. In this paper, several aspects of a rad-hard PLL are investigated, including radiation effects, radiation hardening techniques, PLL building blocks and the overall performance. This circuit is developed using the Peregrine 0.50 /spl mu/m SOS/SOI process. The post-layout simulation result indicates that the circuit can be used to generate 100 M - I80 MHz programmable clock signal under radiation conditions with process, temperature and voltage variations. The maximum peak to peak jitter is less than 100 ps while the maximum lock-in time is less than 20 us under typical conditions.
Dietary habits and gastro-intestinal cancers: a comparative case-control study of stomach and large intestinal cancers in Nagoya, Japan. (1985)

A simultaneous case-control study on stomach cancer and colo-rectal cancer involving 93 cases with stomach cancer, 93 cases with colo-rectal cancer and 186 controls was conducted using a common questionnaire at the Aichi Cancer Center Hospital in 1981-83. A fondness for salty tastes, especially salted foods such as pickled hakusai (vegetable) and dried & salted fishes, which are typical traditional Japanese foods showed a significantly positive association with stomach cancer (relative risk(RR) = 2.60, P less than 0.01). On the other hand, the habit of eating a western-style breakfast, particularly for 10 years or more made a significant contribution to the risk of colon cancer (RR = 2.24, P less than 0.05) but conversely decreased the risk of stomach cancer (RR = 0.50, not significant (NS)) and rectal cancer (RR = 0.40, NS). In this study, relatively frequent intakes (4 times/week) of some vegetables, i.e. pumpkin, green pepper, onion and cabbage, showed high relative risks for both stomach and colon cancers, contrary to the findings of previous epidemiological studies. Cigarette smoking increased the risk of stomach cancer (RR = 1.99, NS) but decreased that of colon cancer (RR = 0.61, NS). There was no positive relation between drinking and cancer at any site. Some other factors with opposite effects on the two contrasting cancers and some independent factors were identified in this comparative case-control study.
Sentiment analysis of Twitter data for predicting stock market movements (2016)

Predicting stock market movements is a well-known problem of interest. Now-a-days social media is perfectly representing the public sentiment and opinion about current events. Especially, Twitter has attracted a lot of attention from researchers for studying the public sentiments. Stock market prediction on the basis of public sentiments expressed on Twitter has been an intriguing field of research. Previous studies have concluded that the aggregate public mood collected from Twitter may well be correlated with Dow Jones Industrial Average Index (DJIA). The thesis of this work is to observe how well the changes in stock prices of a company, the rises and falls, are correlated with the public opinions being expressed in tweets about that company. Understanding author's opinion from a piece of text is the objective of sentiment analysis. The present paper have employed two different textual representations, Word2vec and N-gram, for analyzing the public sentiments in tweets. In this paper, we have applied sentiment analysis and supervised machine learning principles to the tweets extracted from Twitter and analyze the correlation between stock market movements of a company and sentiments in tweets. In an elaborate way, positive news and tweets in social media about a company would definitely encourage people to invest in the stocks of that company and as a result the stock price of that company would increase. At the end of the paper, it is shown that a strong correlation exists between the rise and falls in stock prices with the public sentiments in tweets.
The glia‐derived protease nexin 1 persists for over 1 year in rat brain areas selectively lesioned by transient global ischaemia (1993)

The re-expression of the developmentally regulated serine protease inhibitor glia-derived nexin (GDN) was investigated 1 year after transient global ischaemia induced by the four-vessel occlusion technique in rats. The CA1 sector of the hippocampus was severely shrunken due to the absence of pyramidal cells, but still clearly discernible due to the continued presence of the parvalbumin-containing GABAergic neurons. In this partially neuron-depleted hippocampus, GDN immunoreactivity was found in reactive astrocytes containing glial fibrillary acidic protein. GDN-positive astrocytes were also found in other lesioned areas, the reticular thalamic nucleus and the cerebellar cortex. Thus, the re-expression of GDN in the adult excitotoxically lesioned brain described previously in the gerbil model of ischaemia persists. The continued presence of the protease inhibitor might disturb the proteolytic balance and lead to the deposition of pathological breakdown products of proteins, e.g. beta-amyloid.
Highly Efficient Enzymatic Synthesis of 2‐Monoacylglycerides and Structured Lipids and their Production on a Technical Scale (2007)

We report here a two-step process for the high-yield enzymatic synthesis of 2-monoacylglycerides (2-MAG) of saturated as well as unsaturated fatty acids with different chain lengths. The process consists of two steps: first the unselective esterification of fatty acids and glycerol leading to a triacylglyceride followed by an sn1,3-selective alcoholysis reaction yielding 2-monoacylglycerides. Remarkably, both steps can be catalyzed by lipase B from Candida antarctica (CalB). The whole process including esterification and alcoholysis was scaled up in a miniplant to a total volume of 10 l. With this volume, a two-step process catalyzed by CalB for the synthesis of 1,3-oleoyl-2-palmitoylglycerol (OPO) using tripalmitate as starting material was established. On a laboratory scale, we obtained gram quantities of the synthesized 2-monoacylglycerides of polyunsaturated fatty acids such as arachidonic-, docosahexaenoic- and eicosapentaenoic acids and up to 96.4% of the theoretically possible yield with 95% purity. On a technical scale (>100 g of product, >5 l of reaction volume), 97% yield was reached in the esterification and 73% in the alcoholysis and a new promising process for the enzymatic synthesis of OPO was established.
Design, Synthesis, and Evaluation of a Novel Class of Enantioselective Electrophilic Fluorinating Agents:  <i>N</i>-Fluoro Ammonium Salts of <i>cinchona</i> Alkaloids (F-CA-BF<sub>4</sub>) (2000)

The first enantiopure N-fluoro quaternary ammonium salts of cinchona alkaloids as enantioselective fluorinating agents are reported. A one-step transfer-fluorination on the naturally occurring cinchona alkaloids gave the fluorinating agents F-CA-BF(4). This new generation of fluorinating agents exhibited asymmetric induction up to 61% on fluorination of enolates and silyl enol ethers of 2-methyl-1-tetralone.
ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective (2017)

The occurrence of more than 200 diseases, including cancer, can be attributed to alcohol drinking. The global cancer deaths attributed to alcohol-consumption rose from 243,000 in 1990 to 337,400 in 2010. In 2010, cancer deaths due to alcohol consumption accounted for 4.2% of all cancer deaths. Strong epidemiological evidence has established the causal role of alcohol in the development of various cancers, including esophageal cancer, head and neck cancer, liver cancer, breast cancer, and colorectal cancer. The evidence for the association between alcohol and other cancers is inconclusive. Because of the high prevalence of ALDH2*2 allele among East Asian populations, East Asians may be more susceptible to the carcinogenic effect of alcohol, with most evidence coming from studies of esophageal cancer and head and neck cancer, while data for other cancers are more limited. The high prevalence of ALDH2*2 allele in East Asian populations may have important public health implications and may be utilized to reduce the occurrence of alcohol-related cancers among East Asians, including: 1) Identification of individuals at high risk of developing alcohol-related cancers by screening for ALDH2 polymorphism; 2) Incorporation of ALDH2 polymorphism screening into behavioral intervention program for promoting alcohol abstinence or reducing alcohol consumption; 3) Using ALDH2 polymorphism as a prognostic indicator for alcohol-related cancers; 4) Targeting ALDH2 for chemoprevention; and 5) Setting guidelines for alcohol consumption among ALDH2 deficient individuals. Future studies should evaluate whether these strategies are effective for preventing the occurrence of alcohol-related cancers.
From neuron to brain (1976)

Introduction to the Fifth Edition PART I: INTRODUCTION TO THE NERVOUS SYSTEM Principles of Signaling and Organization Signaling in the Visual System Functional Architecture of the Visual Cortex PART II: ELECTRICAL PROPERTIES OF NEURONS AND GLIA Ion Channels and Signaling Structural Basis of Ion Channel Function The Ionic Basis of the Resting Potential The Ionic Basis of the Action Potential Electrical Signaling in Neurons Transport across Cell Membranes Properties and Functions of Neuroglian Cells PART III: INTERCELLULAR COMMUNICATION Mechanisms of Direct Synaptic Transmission Indirect Mechanisms of Synaptic Transmission Release of Neurotransmitters Neurotransmitters in the Central Nervous System Transmitter Synthesis, Transport, Storage, and Inactivation Synaptic Plasticity PART IV: INTEGRATIVE MECHANISMS Autonomic Nervous System Cellular Mechanisms of Behavior in Ants, Bees, and Leeches PART V: SENSATION AND MOVEMENT Sensory Transduction Transduction and Transmission in the Retina Touch, Pain, and Texture Sensation Auditory and Vestibular Sensation Constructing Perception Circuits Controlling Reflexes, Respiration, and Coordinated Movements PART VI: DEVELOPMENT AND REGENERATION OF THE NERVOUS SYSTEM Development of the Nervous System Critical Periods in Sensory Systems Regeneration of Synaptic Connections after Injury PART VII: CONCLUSION Open Questions Clinical relevance emphasized Appendices Current Flow in Electrical Circuits Metabolic Pathways for the Synthesis and Inactivation of Low Molecular Weight Transmitters Structures and Pathways of the Brain
Optimized design of a back-to-back NPC converter to be used as interface for renewable energies (2005)

As the number of wind power with power electronics interfaces in the grid increases, it becomes unacceptable to disconnect the generating units every time a disturbance occurs, as was a common practice in the past. Keeping the converter online during unbalanced voltage and guaranteeing the actual standards of the converter connected to the grid becomes a very critical issue. From these goals, the design of a robust back-to-back NPC (three levels) converter of 100 KVA is researched in this work. The converter is divided into two main parts: the power electronics system and the control electronics system. In both designs, some important contributions are shown. Concerning the first part, the paper presents primarily the converter limitations to compensate unbalanced dips, the grid filter design and the DC-bus capacitor design. Concerning the control electronics system, the chosen electronic structure and the tasks distribution between the chosen processors are shown.
Design of an Arterial Line Insertion Simulator (2012)

Arterial access is used to accurately measure and monitor blood pressure in real time. An arterial line insertion simulator was designed to be an educational tool used to help train medical professionals to insert radial arterial lines. This simulator was designed to be compatible with the Seldinger or guidewire technique. An arm was constructed to have a radial artery with realistic pulsatile flow. The simulator had a palpable pulse and flashback was present upon cannulation. This simulator was compatible the placement of a radial arterial line using a 21 gauge needle, 0.018Â” guidewire and a 5 French catheter.