gebhart/patrepeval huggingface dataset:
Creation of a polymer backbone in lipid bilayer membrane-based nanotubes for morphological and microenvironmental stabilization (2014)

We report a novel method for morphological and microenvironmental stabilization of single-walled bilayer nanotubes, which involves construction of a polymer backbone between the monolayers by intercalating a monomer, followed by <italic>in situ</italic> polymerization.
Identification of hormone-binding regions of the luteinizing hormone/human chorionic gonadotropin receptor using synthetic peptides. (1992)

A comprehensive series of overlapping synthetic peptides have been used to study the relationship between the primary structure of the ovarian receptor for LH/human CG (hCG) and hormone binding. Twenty-four consecutive, overlap peptides that replicate the entire extracellular domain of the rat luteal receptor have been synthesized by standard solid-phase techniques on an automated synthesizer. Eight additional peptides from the extracellular domain and three peptides replicating the putative extracellular loop regions have also been synthesized. Each peptide was evaluated in RRAs for interaction with hCG by measuring its ability to competitively inhibit binding of 125I-hCG to membrane receptor. Twelve peptides were found to be potent in RRAs and caused a reduction of half-maximal binding of 125I-hCG at concentrations of 10-250 x 10(-6) M. The 12 active peptides (and adjacent inactive peptides) defined at least 4 independent receptor regions that can interact with hormone. One site near the NH2-terminus was localized to receptor residues Arg21-Pro38. Two more sites of hormone interaction were identified by peptides replicating residues Arg102-Thr115 and Tyr253-Phe272. A fourth binding region was identified in the third putative extracellular loop, replicated by rat luteal receptor peptide Lys573-Lys583. The amino acid sequences of the four active rat LH/hCG receptor regions were aligned and compared with published sequences for other glycoprotein hormone receptors. Three regions (Arg102-Thr115, Tyr253-Phe272, and Lys573-Lys583) showed high sequence homology with the human LH/hCG receptor, human TSH receptor, and rat FSH receptor and may represent contact sites for the alpha-subunit of hormone. The other binding region, Arg21-Pro38 had low sequence homology with the other glycoprotein hormone receptors and is postulated to be a binding determinant for beta-hCG/LH. This report demonstrates that synthetic overlap peptides of confirmed sequence can be used to successively identify hormone interaction sites of glycoprotein hormone receptors.
Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndrome (1992)

Abstract We studied serum anti‐glycolipid antibodies by enzymelinked immunosorbent assay and thin‐layer chromatography–enzyme immunoassay in six consecutive patients with typical Miller Fisher syndrome. In all six, increased activity of IgG antibody against ganglioside GQ1b was present in the early phase and reduced with time, whereas such activity was not detected in normal control subjects and disease control subjects including those with Guillain‐Barrë syndrome. Anti‐GQ1b IgG antibody is a new possible diagnostic marker of Miller Fisher syndrome and could well be related to the disease process itself.
Altered pH lysine signalling mutants of <i>cadC</i>, a gene encoding a membrane‐bound transcriptional activator of the <i>Escherichia coli cadBA</i> operon (1994)

The Escherichia coli CadC protein is required for activation of cadBA transcription under conditions of low external pH and exogenous lysine. cadBA encodes proteins involved in the decarboxylation of lysine to cadaverine, and cadaverine excretion. Sequence analysis suggested that CadC contains a single transmembrane segment separating a DNA-binding domain in the amino terminus from a periplasmic domain. Western analysis of subcellular fractions demonstrated that CadC is expressed and concentrated in the cytoplasmic membrane in cells grown either at an inducing pH (pH 5.8) or at a non-inducing pH (pH 7.6). Eight cadC mutants were isolated based on their ability to confer expression of a cadA-lacZ fusion independent of low external pH or exogenous lysine. Five of these mutants expressed the cadA-lacZ fusion at both pH 5.8 and pH 7.6, but retained the requirement for the lysine signal while the other three mutants displayed pH independence at pH 5.8 but not at pH 7.6. These results support a model in which CadC is a membrane-bound transcriptional activator of the cadBA operon capable of sensing (directly or indirectly) signals generated outside the cytoplasmic membrane as a consequence of acidic pH and lysine.
Post-Coital Contraceptive Effects of an Agonistic Analogue of Luteinizing Hormone Releasing Hormone (1976)

An analogue of synthetic hypothalamic LRH, D-[ALA]6-DES-[GLY]10-PRO9-ethylamide-LRH (Wy-18,481) was evaluated for agonistic (in vivo LH-releasing and ovulation-inducing), post-coital contraceptive and reproductive target organ effects. Both LRH and the analogue terminated pregnancy; there appeared to be a direct relationship between agonistic and post-coital contraceptive potency and activity. The analogue proved to be a potent agonist and both a pre-and post-implantational post-coital anti-fertility agent. In contrast to LRH, the congener did not produce a uterotrophic effect in the hypophysectomized rat. The data suggest that agonist analogue(s) of LRH can terminate pregnancy via hyperstimulation of the pituitary-ovarian-reproductive complex and the use of members of this neurohormonal class as potential clinical pro-fertility agents should be weighted with caution.
Robust data equalization, fractional tap spacing and the Zak transform. (1987)

To counter intersymbol interference and noise, a data equalizer must be dimensioned in accordance with the characteristics of the transmission channel that it operates upon. Adaptive techniques can be a suitable means provided that the equalizer is sufficiently flexible. Prior knowledge about the ensemble of possible characteristics may be exploited to equip a non-adaptive equalizer with a sufficiently robust dimensioning to withstand all possible parameter variations. For the most commonly applied types of data equalizer, viz. the linear quantizer, its partial response variants and the decision feedback equalizer, this paper presents a unified derivation of their optimum adaptive and robust versions, using a mean-square measure of performance. The analysis is carried out by using the Zak transform, which is a linear time-frequency signal representation stemming from quantum mechanics.
Kinetic Traits and Enzyme Form Patterns of <i>(R)</i>‐2‐(2,4‐Dichlorophenoxy)propionate/α‐Ketoglutarate Dioxygenase (RdpA) after Expression in Different Bacterial Strains (2006)

Abstract The rdpA gene of strains Delftia acidovorans MC1, Rhodoferax sp. P230, and Sphingobium herbicidovorans MH proved to be identical. However, when RdpA [( R )‐2‐(2,4‐dichlorophenoxy)propionate/α‐ketoglutarate dioxygenase] was investigated after purification from the various strains, significant differences in the kinetics and some chemical properties of the enzymes were observed. The preference for substrates ranged in the order ( R) ‐2‐(2,4‐dichlorophenoxy)propionate (2,4‐DP) > (R) ‐2‐(4‐chloro‐2‐methylphenoxy)propionate (MCPP) >> 2,4‐dichlorophenoxyacetate (2,4‐D) ∼ 4‐chloro‐2‐methylphenoxyacetate (MCPA), but detailed kinetic investigations revealed significant strain‐dependent differences in the k cat and K M values. While the K M values of RdpA from the various strains were low and their range rather narrow with 2,4‐DP (19–60 μM) and MCPP (35–64 μM), larger differences were observed with phenoxyacetates which were distinctly higher and spanned a wider range with 2,4‐D (237–935 μM) and MCPA (164–510 μM). The lowest K M values with 2,4‐D and MCPA were found for RdpA originating from strain P230. Investigation of the enzymes from the various sources by 2D gel electrophoresis revealed up to three monomeric enzyme forms which differed in the pI value. The 2D‐patterns were similar with RdpA from strains MC1 and MH, and after heterologous expression of the enzyme in Escherichia coli , but differed significantly from that of strain P230. The presence of enzyme forms and their different composition coincided apparently with the differences observed in the kinetic properties of RdpA in the various strains. The effects are discussed in terms of posttranslational modification of RdpA which appears to be different in extent and kind in the various strains.
Highly Selective Adsorption for Ethylene, Propylene, and Carbon Dioxide in Silver-Ionized Microporous Polyimide (2018)

This paper presents the sulfonation and silver-ionization modifications using aromatic microporous polyimide (MPI) as precursor to obtain a new Ag+-decorated porous polyimide material (MPI-Ag). FTIR, XPS, and EDX spectra demonstrate the chemical structure of the resultant MPI-Ag and the homogeneously distribution of silver ions within the porous network. The evolution of porosity parameters and elemental compositions of the postmodified polymers and their effects on adsorption/separations of C1–C3 hydrocarbons and CO2 gas are studied in detail. The results show that the modified MPI-Ag exhibits the enhanced affinity for CO2 and the unsaturated hydrocarbons like C2H4 and C3H6 as evidenced by the significantly increased enthalpies of adsorption, Henry’s constants and first virial coefficients. Consequently, at 273 K, the adsorption selectivities of C2H4/C2H6 (0.9) and C3H6/C3H8 (2.0) for MPI dramatically rise to 3.5 and 16.5 for MPI-Ag, respectively. Moreover, the selectivities of C3H6/CH4 (3785) and CO2/CH4 (65.3) are achieved for MPI-Ag, which are among the highest values reported to date for porous materials. The excellent selective adsorptions for unsaturated alkenes and CO2 gas endow MPI-Ag with potential applications in stripping CO2 from natural gas and landfill gas as well as the purification of C2H4 and C3H6 from their mixtures with CH4, C2H6, and C3H6 impurities.
ChemInform Abstract: Chemical Signatures of Fossilized Resins and Recent Plant Exudates. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Low-power high-slew-rate CMOS buffer amplifier for flat panel display drivers (2006)

A new high-slew-rate CMOS buffer amplifier consuming a very small quiescent current is proposed. This buffer amplifier recursively copies the output driving current and increases the tail current of the input differential pair during slewing. Since the proposed buffer has a possible slew rate higher than 10 V/µs for a load capacitance of 1 nF almost independently of static currents as low as 1 µA, this buffer amplifier is promising for column driver ICs of flat panel displays that require low static power consumption, high current driving capabilities, and small silicon areas.
Intracranial Self-Stabbing (2010)

Intracranial self-stabbing appears to be an under-recognized form of self-harm that is associated with, but not limited to, psychotic illness.
SSD vs HDD – data recovery and destruction (2013)

A great deal has been written recently about Solid State Drives (SSDs) and their role in enterprise storage. Articles include several comparisons of solid state drives and mechanical drives in RAID arrays for enterprise applications. While most address several key areas of comparison – cost, performance, capacity, power, cooling and reliability – they often neglect to consider the critical areas of data recovery, data destruction and asset disposal. Solid State Drives (SSDs) have become very popular, not just for laptops but also for enterprise storage. However, most of the debate around them has focused on issues like cost and performance. Little attention has been paid to data recovery and data destruction/asset disposal. The long-established methods used to back up, recover and securely erase data on traditional hard disks don't necessarily work with SSDs. Organisations need to understand these differences if they want to ensure that data is not leaked when assets are disposed of, and that they can recover effectively from disasters, explains Robert Winter of Kroll Ontrack.
Australian Goblin Spiders of the Genus<i>Ischnothyreus</i>(Araneae, Oonopidae) (2014)

Goblin spiders of the genus Ischnothyreus are characterized by small, heavily sclerotized male pedipalps, reduced dorsal and ventral scutes, and heavy spination of the first and second legs. Species of this genus may be distinguished from each other by the variation in the embolic region of the male palp, female genitalia, color, degree and shape of dorsal and ventral sclerotization, and specializations of the chelicerae and endites in the male. A total of 34 Australian species of Ischnothyreus Simon are recognized, all of which are endemic and found throughout the tropical, monsoonal, and subtropical regions of the country. Ischnothyreus darwini Edward and Harvey is the only previously described species, and 33 are newly described: I. arcus, I. barratus, I. bifidus, I. binorbis, I. boonjee, I. bualveus, I. bupariorbis, I. collingwoodi, I. comicus, I. corniculatum, I. cornuatus, I. crenulatus, I. culleni, I. digitus, I. eacham, I. eungella, I. florence, I. hamatus, I. hoplophorus, I. julianneae, I. ker, I. meidamon, I. monteithi, I. nourlangie, I. ovinus, I. piricius, I. pterodactyl, I. puruntatamerii, I. raveni, I. rixi, I. stauntoni, I. tragicus, and I. tumidus. Many of the described species have extremely small geographic ranges, and the genus shows high diversity over relatively small areas. A key, detailed illustrations, and digital images are provided for all Australian species of Ischnothyreus.
Dynamic characteristic of frequency control by rotary frequency converter to link wind farm and power system (2004)

This work proposes an application of rotary frequency converter for a wind farm system. Wind power is getting attention for prospective renewal energy sources, and introduction of wind farm generation will solve environmental matters and energy exhaust problem. However, the quality of power system frequency will be degraded as the capacity of wind power generator increases. Attenuation of mismatch between the served power and load demand is most important problem in order to increase number of wind generators. Here, a large rotary frequency converter is proposed as a buffer to connect the wind farm and the power system. This provides energy storage function of the output power associated with irregular wind power. The converter has a synchronous generator and a doubly-fed machine. The synchronous motor is connected to the wind farm to supply AC voltage for induction generators of wind power generation units. The shaft of the doubly-fed machine is mechanically jointed to the synchronous motor, and rotates together. Tuning the current of the secondary winding supplied by cycloconverter or self-corn mutated inverter controls the output power. At present, doubly-fed machine is commonly used in pumped storage hydraulic power plants recently constructed. The proposed scheme is an expansion from the present application. For the evaluation of the proposed scheme, two simulation tests are carried out. One is load reference setting test for discussion of the power exchange response to a power grid. Other is load frequency control test in order to discuss required capacity for the rotary frequency converter to improve the frequency quality.
Measurement of Ultrasonic Wave Velocities and Elastic Moduli for Small Solid Specimens at High Temperatures (1959)

An improved buffer rod-specimen unit is described for measuring longitudinal wave velocities in solids at temperatures up to 350°C. The method is particularly useful in determining elastic moduli of single crystals since very small path lengths in any prescribed direction can be employed. The use of molten metals to provide coupling at still higher temperatures is discussed. Two methods involving mode conversion at an impedance discontinuity are described for measuring shear wave velocities. Application to crystals of cubic symmetry is detailed, with a note on possible extension to less symmetrical crystals of any orientation. Data for fused silica and single crystal germanium are listed for temperatures up to 300°C in illustration of the methods described.
Brain-CODE: A Secure Neuroinformatics Platform for Management, Federation, Sharing and Analysis of Multi-Dimensional Neuroscience Data (2018)

Historically, research databases have existed in isolation with no practical avenue for sharing or pooling medical data into high dimensional datasets that can be efficiently compared across databases. To address this challenge, the Ontario Brain Institute's "Brain-CODE" is a large-scale neuroinformatics platform designed to support the collection, storage, federation, sharing and analysis of different data types across several brain disorders, as a means to understand common underlying causes of brain dysfunction and develop novel approaches to treatment. By providing researchers access to aggregated datasets that they otherwise could not obtain independently, Brain-CODE incentivizes data sharing and collaboration and facilitates analyses both within and across disorders and across a wide array of data types, including clinical, neuroimaging and molecular. The Brain-CODE system architecture provides the technical capabilities to support (1) consolidated data management to securely capture, monitor and curate data, (2) privacy and security best-practices, and (3) interoperable and extensible systems that support harmonization, integration, and query across diverse data modalities and linkages to external data sources. Brain-CODE currently supports collaborative research networks focused on various brain conditions, including neurodevelopmental disorders, cerebral palsy, neurodegenerative diseases, epilepsy and mood disorders. These programs are generating large volumes of data that are integrated within Brain-CODE to support scientific inquiry and analytics across multiple brain disorders and modalities. By providing access to very large datasets on patients with different brain disorders and enabling linkages to provincial, national and international databases, Brain-CODE will help to generate new hypotheses about the biological bases of brain disorders, and ultimately promote new discoveries to improve patient care.
Interconnection technologies for multichip assemblies (ITMA)-A UK Information Technology Engineering Directorate hybrid wafer scale project (2002)

The Interconnection technology for multichip assemblies (ITMA) project is addressing the application of a silicon-substrate-based multichip module (MCM) technology to the requirements of parallel computing applications in the UK. The program involves activities on MCM design methodology, silicon substrate process technology, device assembly, module packaging technology, the design of VLSI devices specifically for MCM applications, and the implementation of advanced MCM demonstrator modules in parallel computing systems. The objectives of the ITMA project are described, and the technologies employed within the project to realize high-performance MCMs and hybrid wafer scale integration (HWSI) modules are reviewed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
High Performance Media for Phase Change Optical Recording (1999)

We discuss various mechanisms that lead to a high crystallization rate of the recording layer in a phase change disk. The role of interface layers, recording layer composition and its thickness is especially emphasized. Disks with a data bit rate beyond 40 Mbit/s have been realized.
Angiotensin-Converting Enzyme 2 Inhibits Apoptosis of Pulmonary Endothelial Cells During Acute Lung Injury Through Suppressing MiR-4262 (2015)

ACE2-induced suppression of miR-4262 partially contribute to the inhibition of the PEC apoptosis after ALI through Bcl-2. MiR-4262 may be a novel promising treatment target for ALI and ARDS.
Studies of the mechanistic diversity of sodium cyanoborohydride reduction of tosylhydrazones (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies of the mechanistic diversity of sodium cyanoborohydride reduction of tosylhydrazonesVaughn P. Miller, Ding Yah Yang, Theresa M. Weigel, Oksoo Han, and Hung Wen LiuCite this: J. Org. Chem. 1989, 54, 17, 4175–4188Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/jo00278a035https://doi.org/10.1021/jo00278a035research-articleACS PublicationsRequest reuse permissionsArticle Views3673Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts