gebhart/patrepeval huggingface dataset:
Triazole‐Linked DNA as a Primer Surrogate in the Synthesis of First‐Strand cDNA (2011)

A phosphate-eliminated nonnatural oligonucleotide serves as a primer surrogate in reverse transcription reaction of mRNA. Despite of the nonnatural triazole linkages in the surrogate, the reverse transcriptase effectively elongated cDNA sequences on the 3'-downstream of the primer by transcription of the complementary sequence of mRNA. A structure-activity comparison with the reference natural oligonucleotides shows the superior priming activity of the surrogate containing triazole-linkages. The nonnatural linkages also protect the transcribed cDNA from digestion reactions with 5'-exonuclease and enable us to remove noise transcripts of unknown origins.
Absence of increased blood decanoic acid levels in children with epilepsy treated with classic ketogenic diet (2019)

Recently, decanoic acid (C10), a medium-chain fatty acid, was shown to be a direct inhibitor of the AMPA receptor. Accordingly, C10 has been suggested as a potential anticonvulsant factor in the ketogenic diet (KD) or the medium-chain triglyceride KD. Here, we tested whether C10 serum levels correlate with the response to KD in five children (1.5 ± 0.6 years of age) with epilepsy. The serum levels of C10 were measured before and after KD initiation (n=2 at one month, n=3 at three months, and n=1 at six months after initiation) by gas chromatography-mass spectrometry. After three months on KD, two patients were found to be responders. The mean serum level before KD initiation was 63.2 μM. Only one patient, who was a non-responder, showed an increase (5%) in C10 serum level after a month of KD. The remaining four patients (two responders) showed a decrease in the C10 level from -5.3% to -75.5%. Our preliminary data show that KD does not lead to an increase in C10 serum levels, suggesting that increased concentration of C10 might not be directly involved in the anticonvulsant effects of classic KD.
Chromosomal localisation of a gene(s) for Turner stigmata on Yp. (1993)

Although recent cytogenetic and molecular studies in patients with Turner stigmata are consistent with a gene(s) for Turner stigmata being present on both Xp and Yp, the precise location has not been determined. In this report, we describe a phenotypically female infant with Turner stigmata and a partial Yp deletion and review genotype-phenotype correlations of the putative Turner gene(s) in non-mosaic patients with Y chromosome rearrangements resulting from chromosomal breakage at Yp or Yc (pericentromeric region). The results indicate that the putative Turner gene(s) on Yp is located in the Y specific region from interval 1A1A to interval 2B. In addition, assessment of ZFX/ZFY and RPS4X/RPS4Y in the context of the Turner gene(s) suggests that ZFX/ZFY rather than RPS4X/RPS4Y could be a candidate gene for the Turner stigmata.
Effects of vitamin D on calcium regulation in vitamin-D-deficient pigs given a phytate-phosphorus diet (1986)

1. Vitamin-D-deficient pigs were fed on a phytate-phosphorus diet and treated with vitamin D3 (+D) to examine the time-course of adaptative changes in plasma minerals, vitamin D metabolites, parathyroid hormone (PTH) and calcium balance and intestinal Ca-binding protein (CaBP). 2. The 5-week vitamin D repletion (25 micrograms cholecalciferol/kg diet) regimen restored plasma Ca, P and alkaline phosphatase (EC 3.1.3.1) to normal, decreased PTH and markedly and rapidly increased plasma 25-hydroxycholecalciferol (25-OHD, sevenfold after 4 d) and 1,25-dihydroxycholecalciferol (1, 25(OH)2D3, 1.8-fold after 4 d). 3. CaBP concentrations were markedly elevated all along the digestive tract, especially in the distal regions. 4. Ca absorption and retention were enhanced (fourfold and sixfold respectively) by the +D diet. 5. The improved Ca absorption, coupled with increased CaBP and 1,25(OH)2D3 levels, suggest that vitamin D metabolism in phytate-P-fed pigs is sensitive to the depressed Ca availability due to phytate feeding. It also indicates that CaBP may play an important role in the adaptation of Ca absorption. 6. Persistent hypercalciuria indicates that mineral metabolism was still affected by the phytate nature of the dietary P in spite of the vitamin D treatment.
Network bandwidth configuration tool for Xen virtual machines (2010)

Performance differentiation has always been a requirement in virtualized environments, especially in case where virtualization is used in high-end data center applications. In this paper, we present a command-line tool for Network bandwidth differentiation in Xen, which is an open source solution for virtualization. Though the CPU credit scheduler in Xen can be configured using command-line tools to specify weights and caps for a virtual machine, no such tools exist to specify the network bandwidth limits. Through our tool, xmsetbw, network bandwidth limits for a virtual machine in Xen can be specified and dynamically reconfigured (without kernel recompilation). Experimental evaluations show that bandwidth utilization is limited within specified values.
Kirchhoff modeling, inversion for reflectivity, and subsurface illumination (2000)

Abstract Because of its computational efficiency, prestack Kirchhoff depth migration is currently one of the most popular algorithms used in 2-D and 3-D subsurface depth imaging. Nevertheless, Kirchhoff algorithms in their typical implementation produce less than ideal results in complex terranes where multipathing from the surface to a given image point may occur, and beneath fast carbonates, salt, or volcanics through which ray-theoretical energy cannot penetrate to illuminate underlying slower-velocity sediments. To evaluate the likely effectiveness of a proposed seismic-acquisition program, we could perform a forward-modeling study, but this can be expensive. We show how Kirchhoff modeling can be defined as the mathematical transpose of Kirchhoff migration. The resulting Kirchhoff modeling algorithm has the same low computational cost as Kirchhoff migration and, unlike expensive full acoustic or elastic wave-equation methods, only models the events that Kirchhoff migration can image. Kirchhoff modeling is also a necessary element of constrained least-squares Kirchhoff migration. We show how including a simple a priori constraint during the inversion (that adjacent common-offset images should be similar) can greatly improve the resulting image by partially compensating for irregularities in surface sampling (including missing data), as well as for irregularities in ray coverage due to strong lateral variations in velocity and our failure to account for multipathing. By allowing unstacked common-offset gathers to become interpretable, the additional cost of constrained least-squares migration may be justifiable for velocity analysis and amplitude-variation-with-offset studies. One useful by-product of least-squares migration is an image of the subsurface illumination for each offset. If the data are sufficiently well sampled (so that including the constraint term is not necessary), the illumination can instead be calculated directly and used to balance the result of conventional migration, obtaining most of the advantages of least-squares migration for only about twice the cost of conventional migration.
Assigning And Visualizing Music Genres By Web-Based Co-Occurrence Analysis. (2006)

[TODO] Add abstract here.
Resonance Raman spectra of nitrosyl heme proteins and of porphyrin analogs (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTResonance Raman spectra of nitrosyl heme proteins and of porphyrin analogsJ. D. Stong, J. M. Burke, P. Daly, P. Wright, and T. G. SpiroCite this: J. Am. Chem. Soc. 1980, 102, 18, 5815–5819Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/ja00538a019https://doi.org/10.1021/ja00538a019research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hub arc selection for less-than-truckload consolidation (2008)

The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.
Autism: the micro-movement perspective (2013)

The current assessment of behaviors in the inventories to diagnose autism spectrum disorders (ASD) focus on observation and discrete categorizations. Behaviors require movements, yet measurements of physical movements are seldom included. Their inclusion however, could provide an objective characterization of behavior to help unveil interactions between the peripheral and the central nervous systems (CNSs). Such interactions are critical for the development and maintenance of spontaneous autonomy, self-regulation, and voluntary control. At present, current approaches cannot deal with the heterogeneous, dynamic and stochastic nature of development. Accordingly, they leave no avenues for real time or longitudinal assessments of change in a coping system continuously adapting and developing compensatory mechanisms. We offer a new unifying statistical framework to reveal re-afferent kinesthetic features of the individual with ASD. The new methodology is based on the non-stationary stochastic patterns of minute fluctuations (micro-movements) inherent to our natural actions. Such patterns of behavioral variability provide re-entrant sensory feedback contributing to the autonomous regulation and coordination of the motor output. From an early age, this feedback supports centrally driven volitional control and fluid, flexible transitions between intentional and spontaneous behaviors. We show that in ASD there is a disruption in the maturation of this form of proprioception. Despite this disturbance, each individual has unique adaptive compensatory capabilities that we can unveil and exploit to evoke faster and more accurate decisions. Measuring the kinesthetic re-afference in tandem with stimuli variations we can detect changes in their micro-movements indicative of a more predictive and reliable kinesthetic percept. Our methods address the heterogeneity of ASD with a personalized approach grounded in the inherent sensory-motor abilities that the individual has already developed.
Essential design and Risk Management for a next generation ocean dry mate connector (2013)

Dry mate connectors perform essential power and communications interconnect functions. An equally critical function for subsea connectors is to protect the cable and sensitive electronics from flooding, thereby minimizing risk for large, capital intensive projects. This paper will address the technology needed to reduce risk, leap forward in design, and incorporate the very latest design attributes, while demonstrating compliance to evolving industry standards, such as ISO and API. This paper will broadly review the industry's current dry mate connector options, with a focus on reliability and functionality. A Failure Mode and Criticality Analysis (FMECA) will be presented, which will be used to examine typical dry mate connector failure modes. An analysis of these failure modes will be presented, with a focus on the attributes that can be improved on, from the current design state. The paper will then introduce a next generation dry mate connector, which addresses the current design issues, promising to take the next leap in high reliability, interconnect technology for ocean dry mate connectors. Starting with a fresh, ground up look at the requirements from industry, this paper will begin with a blank slate design, and then develop the desired interconnect attributes after a close look at both mil-spec as well as commercial requirements, and the products that are currently on the market. Designed to be a dry mate connector that is ISO/API compliant, the AMETEK SCP dry mate connector is designed to be fully modular. This modularity allows the incorporation of interchangeable electrical or optical circuits, with exceptionally high performance. This modular design then takes a step further, and makes possible the use of a standard approach for either hard cable termination designs, as well as pressure balanced oil filled designs. This new product leaps forward from current industry offerings, and makes a number of improvements and enhancements that reset the bar. Modularity for electrical and optical contacts is one improvement, as is the incorporation of an option for a higher performing fiber optic connection, which incorporates angled polished contacts. These higher performing contacts afford greatly enhanced optical performance, specifically with improved back reflection. This enhancement will help satisfy an increasing industry demand for distributed sensing systems. These types of systems are coming online now as a part of Intelligent Well System designs, and other emerging, distributed acoustic and temperature monitoring systems. Poised to enter both Defense and Oil Gas markets, and improve the status quo, this new product offering takes stock of where the industry is, considers risk elements, and provides a fully up to date design, with options that actually fit industry needs, while reducing risk. This paper will review existing technology, and then introduce this new product, while pointing out improvements over existing designs, explaining the incorporated design attributes, clearly a leap forward in technology.
Design of Adaptive Hot-spot Generator for DMB Contents (2008)

DMB devices, the representative products of convergence between broadcasting and telecommunication, are widely spread over Korea with quite a large user base. With the devices, the audience is able to watch TV with interactive communication capability on the go. However, the usage is limited to video/audio contents due to lack of killer applications for data services. Recently, some authoring tools have appeared supporting only individual services without direct connection to the video content, and Hotspot generation in a simple freeze-frame. It is not feasible to generate Hot-spots with these tools for a dynamic video streaming environment. In this research, we develop an easy Hot-spot generator for a dynamic video streaming environment. We also suggest a system that adapts itself to the input video to achieve a fine quality result.
Planning a green belt around an industrial complex in Uttar Pradesh. (1983)

Based on Bombay High naptha available from Mathura refinery, the Govt. of India is setting up a Petro-chemical complex at Salempur on Mathura-Barellly Highway, District Aligarh, U.P. Unless timely action is taken during the design of construction and operation to contain the same, such complexes have the possibi1ity of thermal and chemical pollution of environment. The project planning authorities mooted the idea of creating a green belt around the proposed complex to be developed by the U. P. Forest Department in consultalion with F. R. I. Trees play an important role in the maintenance and amelioration of environment; they not only improve the atmosphere through absorption of carbon-dioxide and other obnoxious gases and release oxygen, but also help in trapping dust particles and etfuluents in water discharges. Evapo-transpirational processes also moderate temperature to some extent. While doing so, trees also provide aesthetic beauty. In view of the above, it was decided to conduct an indepth study on extent and quality of green belt and the manner in which the same could be achieved most elfeelively. Keeping in view the constraints imposed by locality factors, such as alkaline soil, water logging etc. as also the impact of proposed petrochemical complex, a strategy for establishing of green belt is being evolved. This paper describes the considerations of the choice of species, planting techniques and manner in which the green belt need be maintained. Such an approach will ensure development with the least ecological disturbance i.e. development with out destruction and will provide much needed data base for integrating tree planting while planning major industrial complexes.
Abnormal Glutamate Metabolism in an Adult-Onset Degenerative Neurological Disorder (1982)

In patients with recessive, adult-onset olivopontocerebellar degeneration associated with a partial deficiency of glutamate dehydrogenase, the concentration of glutamate in plasma was significantly higher than that in controls. Plasma alpha-ketoglutarate was significantly lower. Oral administration of monosodium glutamate resulted in excessive accumulation of this amino acid in plasma and lack of increase in the ratio of plasma lactate to pyruvate in the glutamate dehydrogenase-deficient patients. Decreased glutamate catabolism may result in an excess of glutamate in the nervous system and cause neuronal degeneration.
HDMAC coding for MAC compatible broadcasting of HDTV signals (1990)

The authors consider the problem of bandwidth reduction needed to allow HDTV (high-definition television) signals to be transmitted through the narrow DBS (direct broadcast by satellite) channel and to simultaneously fulfil the compatibility requirement with the European DBS transmission standard, the MAC/packet family. This problem is studied in the context of the EUREKA 95 project. The HDMAC coding system is outlined; it is a three-mode system (stationary 80 ms, tracking 40 ms, and dynamic 20 ms modes) with motion compensation used in the 40 ms mode. The system was built in hardware and has been demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Development of V-6 3.5-liter Engine Adopting New Direct Injection System (2006)

<div class="htmlview paragraph">A new V-6 3.5-liter gasoline engine (2GR-FSE) uses a newly developed stoichiometric direct injection system with two fuel injectors in each cylinder (D-4S: Direct injection 4-stroke gasoline engine system Superior version). One is a direct injection injector generating a dual-fan-shaped spray with wide dispersion, while the other is a port injector. With this system, the engine achieves a power level among the highest for production engines of this displacement and a fuel economy rating of 24mpg on the EPA cycle. Emissions are among the lowest level for this class of sedans, meeting Ultra Low Emission Vehicle standards (ULEV-II).</div> <div class="htmlview paragraph">The dual-fan-shaped spray was adopted to improve full-load performance. The new spray promotes a homogeneous mixture without any devices to generate intense in-cylinder air-motion at lower engine speeds. For this reason the engine has improved volumetric efficiency compared to engines having these charge motion devices, resulting in improved full-load performance throughout the engine speed range. Together with Dual VVT-i (Variable intake and exhaust Valve Timing intelligence), the engine achieves specific power near the top of all naturally aspirated production gasoline engines in the world: 66kW/L, 228kW at 6400r/min.</div> <div class="htmlview paragraph">Fuel economy is improved compared to a conventional DISI engine with both injectors optimized to improve combustion. As for improvement of the exhaust emissions, simultaneous injection by the two injectors is effective in reduction of HC emissions during cold start.</div>
On the automation of physical database design (1993)

The design of an optimol physical database entails art exponential time complexity. This is the main reason which haa shifted the attention of researchers to the problem of determining a good physical database design. Two kinds of approaches have been proposed to find a good physical design, an optimizer and a knowledge based approach. An optimizer based approach is characterizti by generating physical dsigns on basis of extracted information from the optimizer. The knowledge baaed approach is characterized by represertting the knowledge of experts, not necessarily knowledge with regard to optimizers, into rules. In this paper we will propose a framework of a tool based on a combination of both approaches which can assist in finding a good physical design. In our approach we deal in a fundamental way with knowledge based aspects such as how to represent knowledge into rules and how to combine different rules. Knowledge based approaches for physical design take ad hoc deciaiona for these subjects. We believe that these kinds of decisions are essential for a knowledge based approach because the generated solutions are determined by the rules and combkiation of rules. We will present a technique how to model knowledge in a more proper way into rules. This makes it possible to combine rules in a founded way with the Dempster-Shafer theory, finally leading to a good proposrd for physical design.
Switched Multi-Radio Transmission Diversity for Non-Collocated Radio Accesses (2006)

We evaluate the spectral efficiency gains observed through multi-radio transmission diversity (MRTD), whereby packets of data are jointly scheduled for downlink transmission over multiple independent radio accesses. We specifically address downlink switched MRTD employed across macro- and pico-cellular radio accesses with non-collocated base stations in a hierarchical cell structure. It is shown that while significant gains can be achieved via MRTD among collocated macro-cell (or pico-cell) base stations, tight cooperation across non-collocated macro-and pico-cell base stations is only beneficial for a small subset of possible geometries. The impact of CQI reporting delays is also investigated
In Situ Precipitation of Gold Nanoparticles onto Glass for Potential Architectural Applications (2004)

The optical properties of in situ deposited gold nanoparticle coatings are investigated for potential application in architectural glass. It is found that the optical properties of the coating can be controlled by the pH of the deposition solution. At a pH of 5.1, the color of the coatings develops from pink, through violet, to blue in transmission. This is due to a plasmon resonance peak at 520 nm from isolated particles, and one at about 700 nm due to near-field dipole interactions, with an intermediate zone of the coexistence of the two, which produces the violet color. However, the two peaks do not coexist in the spectra of coatings produced at pH 8.0 or 10.0, with the peak due to the 520 nm resonance being swamped by the development of the resonance due to particle−particle interactions. In all cases the 700 nm peak could be broadened and red-shifted by increasing the deposition time. The reasons for these differences are explored and are shown to be attributable to the smaller, more aggregated morphology of nanoparticles precipitated at the higher pHs. The wavelength of maximum plasmon resonance is examined as a function of the volume fraction of nanoparticles. Significant deviations from the well-known Genzel−Martin analytical model are observed. The reasons for deviation of the model are discussed. Finally, it is shown how coatings that are blue or blue-gray in transmission can be obtained by exploiting this deviation. Such coatings may be more suitable for architectural application than the conventional pink-hued coatings obtained with colloidal gold nanoparticles.