gebhart/patrepeval huggingface dataset:
Biomechanics in Orthopedic Trauma: Bone Fracture and Fixation (1994)

Basic concepts in biomechanics of fractures and fixation fractures affecting the strength of bone mechanisms of fracture of bone the environment for fracture healing basic implants the upper extremity the spine and pelvis the lower extremity.
Relationship between drug exposure and the efficacy and safety of bupropion sustained release for smoking cessation (2001)

A population pharmacokinetic and pharmacodynamic analysis evaluated the relationships of dose, plasma concentrations of bupropion and metabolites, and patient covariates with the safety and efficacy of bupropion sustained release (SR) for smoking cessation. A total of 519 outpatient chronic cigarette smokers were randomized to one of three bupropion SR doses: 100, 150, or 300 mg/day or placebo. The bupropion plasma concentration time data were fit and subject-specific bayesian estimates of clearance were obtained. Logistic regression analyses evaluated the role of dose, concentrations, and covariates in predicting efficacy and safety endpoints. For the evaluation of efficacy, patients were classified as quitters or non-quitters on the basis of a 4-week quit variable (defined as complete abstinence for weeks 4-7 of the study). For the evaluation of safety, patients were classified into two categories for each adverse event evaluated, corresponding to whether the patient ever experienced the adverse event during the course of the study or never experienced the event, regardless of whether the event was treatment-emergent. The efficacy of bupropion SR in facilitating smoking cessation was found to be related to dose and a mean metabolite concentration, and quitting in general was found to be related to the number of cigarettes smoked per day at baseline. Smoking cessation was 1.42, 1.69, and 2.84 times more likely in patients receiving 100, 150, and 300 mg/day of bupropion SR, respectively, as compared to placebo (p = 0.0001). As the baseline number of cigarettes smoked per day increased, the likelihood of quitting decreased regardless of the treatment condition. Insomnia and dry mouth were positively associated with mean metabolite concentrations, and dry mouth was inversely related to patient weight. Anxiety was inversely related to predicted steady-state concentration (Cpss), suggesting a positive effect on this withdrawal symptom. Bupropion SR exhibits a statistically significant dose/plasma level-response relationship for smoking cessation. Dry mouth and insomnia, related to concentrations, may be managed with dose reduction, with the realization that smoking cessation may be impaired.
Studies on the Utilization of Hydrocarbons by Microorganisms (1970)

In order to convert fumaric acid to l-malic acid continuously by hydrocarbon fermentation, the cultivation of Candida utilis IAM 4215 or Pichia membranaefaciens IAM 4122 which have a high fumarase activity was combined with fumaric acid fermentation by Candida hydrocarbofumarica. Forty strains of yeasts were tested for their fumarase activities. P. membranaefaciens IAM 4122 and C. utilis IAM 4215 indicated the high activity. After C. hydrocarbofumarica was incubated in n-paraffin medium for 5 days, fumaric acid produced was converted to l-malic acid by the associated culture with P. membranaefaciens IAM 4122 for 4 or 5 days. Yields of l-malic acid based on n-paraffin were 72 % and 70 % by P. membranaefaciens and C. utilis, respectively.
Effects of ritobegron (KUC-7483), a novel β<sub>3</sub>-adrenoceptor agonist, on both rat bladder function following partial bladder outlet obstruction and on rat salivary secretion: a comparison with the effects of tolterodine (2012)

The objective of this study was to investigate the effects of the β3-adrenoceptor (AR) agonist ritobegron on rat bladder function following partial bladder outlet obstruction and on rat salivary secretion. In addition, the effects of ritobegron were compared with those of the anti-muscarinic agent tolterodine. After a 6-week partial bladder outlet obstruction (BOO), drug effects on bladder functions were evaluated using cystometrography. Effects on carbachol (CCh)-induced salivary secretion were evaluated in urethane-anesthetized rats. Ritobegron significantly decreased the frequency of non-voiding contractions (NVC), while both ritobegron and tolterodine each significantly decreased the amplitude of NVC. Ritobegron had no effect on either the micturition pressure (MP) or the residual volume (RV). In contrast, tolterodine dose-dependently decreased MP and increased RV. Ritobegron had no effect on CCh-induced salivary secretion, whereas tolterodine dose-dependently decreased it. Ritobegron decreased both the frequency and amplitude of NVC, which is similar to its effect on the contractions associated with detrusor overactivity (DO) in patients with an overactive bladder (OAB), without affecting MP, RV, or CCh-induced salivary secretion. Although tolterodine reduced the amplitude of NVC, it also markedly increased RV and significantly inhibited CCh-induced salivary secretion. These results suggest that use of ritobegron, a β3-AR agonist, is unlikely to lead to the residual urine and dry mouth symptoms that are associated with anti-muscarinic drugs, and that ritobegron may hold promise as a safe and effective agent for OAB treatment.
Learning Sparse Image Codes using a Wavelet Pyramid Architecture (2000)

We show how a wavelet basis may be adapted to best represent natural images in terms of sparse coefficients. The wavelet basis, which may be either complete or overcomplete, is specified by a small number of spatial functions which are repeated across space and combined in a recursive fashion so as to be self-similar across scale. These functions are adapted to minimize the estimated code length under a model that assumes images are composed of a linear superposition of sparse, independent components. When adapted to natural images, the wavelet bases take on different orientations and they evenly tile the orientation domain, in stark contrast to the standard, non-oriented wavelet bases used in image compression. When the basis set is allowed to be overcomplete, it also yields higher coding efficiency than standard wavelet bases. 1 Introduction The general problem we address here is that of learning efficient codes for representing natural images. Our previous work in this...
Modelling the vertical UL 94 test: competition and collaboration between melt dripping, gasification and combustion (2014)

Summary An experimental and numerical investigation of the effect of bisphenol A bis(diphenyl phosphate) (BDP) and polytetrafluoroethylene (PTFE) on the fire behaviour of bisphenol A polycarbonate/acrylonitrile butadiene styrene (PC/ABS) in the vertical UL 94 scenario is presented. Four PC/ABS blends were discussed, which satisfy different UL 94 classifications due to the competing effects of gasification, charring, flame inhibition and melt flow/dripping. For numerical investigation, the particle finite element method (PFEM) is used. Its capability to model the complex fire behaviour of polymers in the UL 94 is analysed. The materials' properties are characterised, in particular the additives impact on the dripping behaviour during thermal exposure. BDP is an efficient plasticiser; adding PTFE prevents dripping by causing a flow limit. PFEM simulations reproduce the dripping and burning behaviour, in particular the competition between gasification and dripping. The thermal impact of both the burner and the flame is approximated taking into account flame inhibition, charring and effective heat of combustion. PFEM is a promising numerical tool for the investigation of the fire behaviour of polymers, particularly when large deformations are involved. Not only the principal phenomena but also the different UL 94 classifications and the extinction times are well predicted. Copyright © 2014 John Wiley & Sons, Ltd.
Growth Hormone and Dexamethasone Stimulate Lipolysis and Activate Adenylyl Cyclase in Rat Adipocytes by Selectively Shifting Gi 2 to Lower Density Membrane Fractions (1999)

GH, in the presence of glucocorticoid, produces a delayed increase in lipolysis in rat adipose tissue, but the biochemical mechanisms that account for this action have not been established. Other lipolytic agents rapidly activate adenylyl cyclase (AC) and the resulting production of cAMP initiates a chain of reactions that culminates in the activation of hormone-sensitive lipase. We compared responses of segments of rat epididymal fat or isolated adipocytes to 30 ng/ml GH and 0.1 μg/ml dexamethasone (Dex) with 0.1 ng/ml isoproterenol (ISO), which evoked a similar increase in lipolysis. All measurements were made during the fourth hour after the addition of GH+Dex or immediately after the addition of ISO to cells or tissues that had been preincubated for 3 h without hormone. Although no significant increases in cAMP were discernible in homogenates of GH+Dex-treated tissues, RP-cAMPS (RP-adenosine 3′5′-phosphothioate), a competitive inhibitor of cAMP, was equally effective in decreasing lipolysis induced by GH+Dex or ISO. The proportion of PKA that was present in the active form was determined by measuring the incorporation of 32P from[γ -32P]ATP into kemptide in the absence and presence of saturating amounts of cAMP. GH+Dex and ISO produced similar increases in protein kinase A activity in tissue extracts. Treatment with GH+Dex did not change the total forskolin-stimulated AC present in either a crude membrane pellet sedimented at 16K × g or a less dense membrane pellet sedimented at 100K × g, but doubled the AC activity in the 16K pellet when assayed in the absence of forskolin. To evaluate possible effects on G proteins, pellets obtained from centrifugation of adipocyte homogenates at 16K × g and 100K × g were solubilized and subjected to PAGE and Western analysis. GH+Dex decreased Giα2 by 44% (P < 0.02) in the 16K pellets and increased it by 52% (P < 0.01) in the 100K pellets. Gsα in the 16K pellet was unaffected by GH+Dex and was decreased (P < 0.05) in the 100K pellet. Sucrose density fractionation of the 16K pellets revealed a similar GH+Dex-dependent shift of Giα2 to less dense fractions as determined by both Western analysis and[ 32P]NAD ribosylation catalyzed by pertussis toxin. No such changes were seen in the distribution of Gsα or 5′-nucleotidase. Colchicine (100 μm) blocked the GH+Dex-dependent shift of Giα2 from the 16K to the 100K pellet and blocked the lipolytic effects of GH+Dex, but not those of ISO. We conclude that by modifying the relationship between AC and Giα2, GH+Dex relieves some inhibition of cAMP production and consequently increases lipolysis.
Near Infrared Light-Powered Janus Mesoporous Silica Nanoparticle Motors (2016)

We describe fuel-free, near-infrared (NIR)-driven Janus mesoporous silica nanoparticle motors (JMSNMs) with diameters of 50, 80, and 120 nm. The Janus structure of the JMSNMs is generated by vacuum sputtering of a 10 nm Au layer on one side of the MSNMs. Upon exposure to an NIR laser, a localized photothermal effect on the Au half-shells results in the formation of thermal gradients across the JMSNMs; thus, the generated self-thermophoresis can actively drive the nanomotors to move at an ultrafast speed, for instance, up to 950 body lengths/s for 50 nm JMSNMs under an NIR laser power of 70.3 W/cm(2). The reversible "on/off" motion of the JMSNMs and their directed movement along the light gradient can be conveniently modulated by a remote NIR laser. Moreover, dynamic light scattering measurements are performed to investigate the coexisting translational and rotational motion of the JMSNMs in the presence of both self-thermophoretic forces and strong Brownian forces. These NIR-powered nanomotors demonstrate a novel strategy for overcoming the necessity of chemical fuels and exhibit a significant improvement in the maneuverability of nanomotors while providing potential cargo transportation in a biofriendly manner.
Chromosomal Integration of Klebsiella Nitrogen Fixation Genes in Escherichia coli (1974)

SUMMARY Escherichia coli, c-m7, a His+Nif+ hybrid obtained by intergeneric mating with a Klebsiella pneumoniae donor strain, also inherited the unselected markers gnd and rfb. The R factor, R144drd3, which had been used to confer fertility on the donor, was present, detectable as covalently closed circular DNA of molecular weight 69 × 106 daltons. No other species of supercoiled DNA were isolated and the elimination of R144drd3 did not result in the loss of Klebsiella genes. Segregation analysis of donor markers indicated that the Klebsiella DNA was integrated at the his region of the E. coli chromosome in the probable order his-gnd-nif-rfb. Strain c-m7 produced a nitrogenase physiologically identical to that of K. pneumoniae, but synthesized a heteromeric species of gluconate-6-phosphate dehydrogenase.
Risk of Sick Leave Associated with Outdoor Air Supply Rate, Humidification, and Occupant Complaints (2000)

We analyzed 1994 sick leave for 3,720 hourly employees of a large Massachusetts manufacturer, in 40 buildings with 115 independently ventilated work areas. Corporate records identified building characteristics and IEQ complaints. We rated ventilation as moderate (approximately 25 cfm/person, 12 ls-1) or high (approximately 50 cfm/person, 24 ls-1) outdoor air supply based on knowledge of ventilation systems and CO2 measurements on a subset of work areas, and used Poisson regression to analyze sick leave controlled for age, gender, seniority, hours of non-illness absence, shift, ethnicity, crowding, and type of job (office, technical, or manufacturing worker). We found consistent associations of increased sick leave with lower levels of outdoor air supply and IEQ complaints. Among office workers, the relative risk for short-term sick leave was 1.53 (95% confidence 1.22-1.92) with lower ventilation, and 1.52 (1.18-1.97) in areas with IEQ complaints. The effect of ventilation was independent of IEQ complaints and among those exposed to lower outdoor air supply rates the attributable risk of short-term sick leave was 35%. The cost of sick leave attributable to ventilation at current recommended rates was estimated as $480 per employee per year at Polaroid. These findings suggest that net savings of $400 per employee per year may be obtained with increased ventilation. Thus, currently recommended levels of outdoor air supply may be associated with significant morbidity, and lost productivity on a national scale could be as much as $22.8 billion per year. Additional studies of IEQ impacts on productivity and sick leave, and the mechanisms underlying the apparent association are needed.
High-Resolution Three-Dimensional Microelectrode Brain Mapping Using Stereo Microfocal X-ray Imaging (2008)

Much of our knowledge of brain function has been gleaned from studies using microelectrodes to characterize the response properties of individual neurons in vivo. However, because it is difficult to accurately determine the location of a microelectrode tip within the brain, it is impossible to systematically map the fine three-dimensional spatial organization of many brain areas, especially in deep structures. Here, we present a practical method based on digital stereo microfocal X-ray imaging that makes it possible to estimate the three-dimensional position of each and every microelectrode recording site in "real time" during experimental sessions. We determined the system's ex vivo localization accuracy to be better than 50 microm, and we show how we have used this method to coregister hundreds of deep-brain microelectrode recordings in monkeys to a common frame of reference with median error of <150 microm. We further show how we can coregister those sites with magnetic resonance images (MRIs), allowing for comparison with anatomy, and laying the groundwork for more detailed electrophysiology/functional MRI comparison. Minimally, this method allows one to marry the single-cell specificity of microelectrode recording with the spatial mapping abilities of imaging techniques; furthermore, it has the potential of yielding fundamentally new kinds of high-resolution maps of brain function.
Clinical remission of systemic lupus erythematosus after human immunodeficiency virus infection. (2007)

Human immunodeficiency virus (HIV) infection during the course of systemic lupus erythematosus (SLE) is unusual. The clinical manifestations of SLE can be influenced by the HIV infection. Worsening of HIV has been documented after the use of immunosuppressives. We describe a case of a 37-year-old male patient who underwent complete clinical remission of SLE after serologic conversion.
Nutritional Needs in Cold and High-Altitude Environments (1996)

This book reviews the research pertaining to nutrient requirements for working in cold or in high-altitude environments and states recommendations regarding the application of this information to military operational rations. It addresses whether, aside from increased energy demands, cold or high-altitude environments elicit an increased demand or requirement for specific nutrients, and whether performance in cold or high-altitude environments can be enhanced by the provision of increased amounts of specific nutrients.
Mobile Cloud Computing Security as a Service using Android (2014)

Cloud Computing is from one of the most prominent technologies that are used today. A lot of business is growing using the computational resources on pay per use model. As more and more enterprise applications are shifting to mobile these days security becomes a big issue to be answered. This paper will give a review for how mobile cloud computing is getting in an upper edge. The security concerns are shown in this paper and an security mechanism is proposed which will secure the data on the Smartphone's using the computation of the cloud..
Three-dimensional trajectory optimization for aircraft (1990)

A solution method for determining three-dimensional minimum-time aircraft trajectories for aircraft is described. The method is based on Euler-Lagrange optimization theory and energy state approximations. The optimal controls are found by either maximizing or minimizing a modified Hamiltonian. The starting extremum operation and the switching conditions from one extremum operation to the other are determined. The solution is computed by iteration on the two constant adjoint variables. The solution convergence, however, is sensitive to these parameters. A method based on the characteristics of the heading adjoint variable is used to reduce this sensitivity. A roll angle chattering solution, which occurs during the minimum power energy loss segment of the trajectory and causes computational problems, is removed by including a penalty on the roll angle magnitude in the performance criterion. A number of specific problems are then solved.
Fifty years of cancer incidence: CI5 I–IX (2010)

The Cancer Incidence in Five Continents (CI5) series comprises nine volumes that bring together peer-reviewed results from population-based cancer registries worldwide. The aim of each is to make available comparable data on cancer incidence from as wide a range of geographical locations as possible. In addition, the existence of long time series of data allows the evolution of risk in different populations over time to be studied. The CI5 I-IX database brings together the results from all nine volumes, spanning a period of some 50 years. In addition, unpublished annual data, with more diagnostic detail, are made available for many cancer registries with 15 or more years of recent data. We describe the construction and composition of the CI5 databases, and provide examples of how they can be used to prepare tables and graphs comparing incidence rates between populations. This is the classical role of descriptive statistics: to allow formulation of hypotheses that might explain the observed differences (geographically, over time, in population subgroups) and that can be tested by further study. Such statistics are also essential components in the planning and evaluation of cancer control programmes.
A Highly Sensitive Fiber-Optic Microphone Based on Graphene Oxide Membrane (2017)

We present a fiber-optic microphone (FOM) based on graphene oxide (GO) membrane in this study. A Fabry-Perot cavity consisting of a single-mode fiber and a piece of GO membrane works as the acoustic sensing structure. Using the GO as the core acoustic sensing component, the fabricating process of the FOM is demonstrated to be simple and efficient. Acoustic tests show that this FOM achieves an average minimum detectable pressure of 10.2 μPa/Hz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sup> , while maintaining a linear acoustic pressure response and a flat frequency response in the range of 100 Hz to 20 kHz. These results indicate the excellent suitability of this FOM for acoustic detection in the audible range with high sensitivity and high fidelity.
식품 매트릭스 중의 농약성분 확인을 위한 고감도이며 새로운 정성적 접근 (2018)

Consumer concerns and federal regulations make pesticide residue analysis an important component of ensuring food safety. Also with growing global trade as well as varying international regulations, the need for multi-analyte screening procedures to efficiently detect violating residues is ever increasing. It is desirable to rapidly and reliably screen samples for a large number of pesticides with sensitive and confirmatory methods as possible. Limitations may exist due to the complexity of sample matrices and differing physicochemical characteristics of contaminating compounds, thus requiring replication of work, to ensure all residues of interest can be targeted. This work reports the development of a screening method for the determination of multi-class and multi-residue pesticides from agricultural processes in complex foodstuffs. All solvent standards, matrix matched standards and sample extracts were analyzed using UPLC coupled with a high sensitivity tandem quadrupole mass spectrometer. Further enhancements in analytical efficiencies were achieved utilizing the functionality of the ESI source versus UniSpray, operated at atmospheric pressure. Exploiting the key functionality of the high velocity droplet stream, ionization efficiency is increased while extending the scope of multiclass analytes screened to excelled levels of detection in a single workflow. Also a novel confirmatory strategy (Product Ion Confirmation Scanning, PICS) was assessed to ensure the method that was acquired using multi reaction monitoring (MRM) on a tandem quadrupole mass spectrometer.
A Comprehensive Genetic Association Study of Alzheimer Disease in African Americans (2011)

Some genes contribute to AD pathogenesis in both white and African American cohorts, although it is unclear whether the causal variants are the same. A larger African American sample will be needed to confirm novel gene associations, which may be population specific.