gebhart/patrepeval huggingface dataset:
Terpolymerization of acrylonitrile, styrene, and 2,3‐dibromopropyl acrylate (1983)

Abstract The terpolymerization of acrylonitrile with styrene and 2,3‐dibromopropyl acrylate in emulsion and dimethyl formamide solution was investigated. Polymerizations, when stopped at low conversions, yielded terpolymers that showed good agreement between experimental and theoretical copolymerization composition data, calculated from the Alfrey‐Goldfinger equation. The relationship between monomer feed and terpolymer compositions is displayed on triangular coordinate graphs proposed by Slocombe. By using a computer program the lines of unique composition and binary azeotropic composition for both systems were established. In the case of emulsion polymerization the azeotropic ternary point was determined at a molar ratio for acrylonitrile/styrene/2,3‐dibromopropyl acrylate of 0.27/0.61/0.12. The experimental results of emulsion terpolymerization fit the calculated curves satisfactorily over a wide range of monomer compositions up to high conversions. The influence of 2,3‐dibromopropyl acrylate on the thermal and flammability characteristics of the terpolymers is described.
Alterations in metabolism and gap junction expression may determine the role of astrocytes as “good samaritans” or executioners (2005)

Our knowledge of astroglia and their physiological and pathophysiological role(s) in the central nervous system (CNS) has grown during the past decade, revealing a complex picture. It is becoming increasingly clear that glia play a significant role in the homeostasis and function of the CNS and that neurons should no longer be considered the only cell type that responds, both rapidly and slowly, to electrochemical activity. We discuss recent advances in the field with an emphasis on the impact of hypoxia and ischemia on astrocytic metabolism and the functional relationship between glucose metabolism and gap junctions in astrocytes. We also address the controversy over whether astrocytic gap junctions mediate protection or killing of neurons during or after hypoxic or ischemic insults.
Art and “Perversion” (1991)

On April 25, 1990, Jock Sturges returned home from swimming at the University of San Francisco pool to find his house and studio overrun by FBI agents and San Francisco police officers. Sturges was being investigated for producing “child pornography”—in this case, portraits of nude pubescent and prepubescent girls.1 In a raid that lasted most of the day, law-enforcement officials removed nearly all of Sturges's camera, darkroom, and studio equipment, his computer and business records, personal diaries, correspondence, address books, a copy of NabokoVapos;s Lolita, and hundreds of thousands of negatives and photographs, nudes and non-nudes alike.2
The fragile X mental retardation protein inhibits translation via interacting with mRNA (2001)

Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMRP. The function of FMRP is unknown, as is the mechanism by which its loss leads to cognitive deficits. Recent studies have determined that FMRP is a selective RNA-binding protein associated with polyribosomes, leading to the hypothesis that FMRP may be involved in translational regulation. Here we show that purified recombinant FMRP causes a dose-dependent translational inhibition of brain poly(A) RNA in rabbit reticulocyte lysate without accelerated mRNA degradation. In our translation reaction FMRP interacts with other messenger ribonucleoproteins and pre-exposure of FMRP to mRNA significantly increased the potency of FMRP as a translation inhibitor. Translation suppression by FMRP is reversed in a trans-acting manner by the 3'-untranslated portion of the Fmr1 message, which binds FMRP, suggesting that FMRP inhibits translation via interacting with mRNA. Consistently FMRP suppresses translation of the parathyroid hormone transcript, which binds FMRP, but not the beta-globin transcript, which does not bind FMRP. Moreover, removing the FMRP-binding site on a translation template abolishes the inhibitory effect of FMRP. Taken together, our results support the hypothesis that FMRP inhibits translation via interactions with the translation template.
Arterial Smooth Muscle Cell Heterogeneity (2003)

During atheromatous plaque formation or restenosis after angioplasty, smooth muscle cells (SMCs) migrate from the media toward the intima, where they proliferate and undergo phenotypic changes. The mechanisms that regulate these phenomena and, in particular, the phenotypic modulation of intimal SMCs have been the subject of numerous studies and much debate during recent years. One view is that any SMCs present in the media could undergo phenotypic modulation. Alternatively, the seminal observation of Benditt and Benditt that human atheromatous plaques have the features of a monoclonal or an oligoclonal lesion has led to the hypothesis that a predisposed, medial SMC subpopulation could play a crucial role in the production of intimal thickening. The presence of a distinct SMC population in the arterial wall implies that under normal conditions, SMCs are phenotypically heterogeneous. The concept of SMC heterogeneity is gaining wider acceptance, as shown by the increasing number of publications on this subject. In this review, we discuss the in vitro studies that demonstrate the presence of distinct SMC subpopulations in arteries of various species, including humans. Their specific features and their regulation will be highlighted. Finally, the relevance of an atheroma-prone phenotype to intimal thickening formation will be discussed.
Hydrogen Sulfide Maintains Mitochondrial DNA Replication <i>via</i> Demethylation of <i>TFAM</i> (2015)

CSE/H2S system contributes to mtDNA replication and cellular bioenergetics and provides a novel therapeutic avenue for cardiovascular diseases.
A Case Study for Fault Tolerance Oriented Programming in Multi-core Architecture (2009)

The multi-core architecture brings more and more challenges and means to common software developers. Reliable software system design approaches can give a high confidence that long-running online software systems run correctly. But anyway these approaches will certainly cause the loss of the efficiency. We found that the multi-core architecture is a quite suitable platform to support reliable software system design and can make the cost acceptable because of its advantages of the parallel performance and prevalence. In this paper we make use of the multi-core architecture to support software fault tolerance. This approach will make the integration of software fault tolerance and the multi-core architecture as a common design choice. According to the idea of software fault tolerance, for some key software units in a system we can develop N separate versions of them with equivalent functionalities. Each version is developed independently by an isolated group to prevent identical faults among versions. All implemented versions run separately from same initial conditions and inputs. Outputs of all redundant versions are submitted to a decision module that determines a single result from multiple results as the correct output. In this paper, we give a case study to show that with the multi-core architecture, the redundant versions of a key software unit can run in parallel on different cores to improve the efficiency.
Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins (2001)

By screening a yeast two-hybrid library with COOH-terminal fragments of vinculin/metavinculin as the bait, we identified a new protein termed raver1. Raver1 is an 80-kD multidomain protein and widely expressed but to varying amounts in different cell lines. In situ and in vitro, raver1 forms complexes with the microfilament-associated proteins vinculin, metavinculin, and alpha-actinin and colocalizes with vinculin/metavinculin and alpha-actinin at microfilament attachment sites, such as cell-cell and cell matrix contacts of epithelial cells and fibroblasts, respectively, and in costameres of skeletal muscle. The NH2-terminal part of raver1 contains three RNA recognition motifs with homology to members of the heterogeneous nuclear RNP (hnRNP) family. Raver1 colocalizes with polypyrimidine tract binding protein (PTB)/hnRNPI, a protein involved in RNA splicing of microfilament proteins, in the perinucleolar compartment and forms complexes with PTB/hnRNPI. Hence, raver1 is a dual compartment protein, which is consistent with the presence of nuclear location signal and nuclear export sequence motifs in its sequence. During muscle differentiation, raver1 migrates from the nucleus to the costamere. We propose that raver1 may coordinate RNA processing and targeting as required for microfilament anchoring in specific adhesion sites.
Development of a Turbine Rotor of Silicon Nitride (1977)

Abstract Description of the development of ceramic turbine rotor consisting of a hot pressed silicon nitride hub and reaction sintered silicon nitride blade ring. Three different fabrication concepts are being investigated. At room temperature, prototype rotors have attained circumferential speeds up to 385 m/s. Simplified blade rings have survived gas temperature changes of 500 K/s. At temperatures of 1170 K, oxidation may reduce the strength of a reaction sintered component.
-Lipoic acid and -lipoamide prevent oxidant-induced lysosomal rupture and apoptosis (2001)

Alpha-lipoic acid (LA) and its corresponding derivative, alpha-lipoamide (LM), have been described as antioxidants, but the mechanisms of their putative antioxidant effects remain largely uncharacterised. The vicinal thiols present in the reduced forms of these compounds suggest that they might possess metal chelating properties. We have shown previously that cell death caused by oxidants may be initiated by lysosomal rupture and that this latter event may involve intralysosomal iron which catalyzes Fenton-type chemistry and resultant peroxidative damage to lysosomal membranes. Here, using cultured J774 cells as a model, we show that both LA and LM stabilize lysosomes against oxidative stress, probably by chelating intralysosomal iron and, consequently, preventing intralysosomal Fenton reactions. In preventing oxidant-mediated apoptosis, LM is significantly more effective than LA, as would be expected from their differing capacities to enter cells and concentrate within the acidic lysosomal compartment. As previously reported, the powerful iron-chelator, desferrioxamine (Des) (which also locates within the lysosomal compartment), also provides protection against oxidant-mediated cell death. Interestingly, although Des enhances the partial protection afforded by LA, it confers no additional protection when added with LM. Therefore, the antioxidant actions of LA and LM may arise from intralysosomal iron chelation, with LM being more effective in this regard.
"Gentle Student Bend Thine Ear To My Speech" An Essay About Sojourner Truth, Abolitionist and Feminist (1994)

Sojourner Truth provides a powerful model of advocacy for the social work profession. This paper offers an analysis of this important historical figure that centers around the implications of being a doubly oppressed minority. An analysis of the nineteenth century chattel slavery system sets the stage for understanding the social environment. A brief biography of her life and evolution from enslaved chattel to feminist activist will highlight her social, spiritual, and personal development. Her philosophy, which is compatible with the modern feminist movement, is outlined by an analysis of her speeches.
Markov chain Monte Carlo estimation of exponential random graph models (2002)

This paper is about estimating the parameters of the exponential random graph model, also known as the p # model, using frequentist Markov chain Monte Carlo (MCMC) methods. The exponential random graph model is simulated using Gibbs or Metropolis-Hastings sampling. The estimation procedures considered are based on the Robbins-Monro algorithm for approximating a solution to the likelihood equation.
A Valveless Pneumatic Fluid Transfer Technique Applied To Standard Additions on a Centrifugal Microfluidic Platform (2011)

This paper demonstrates a valveless pneumatic fluid transfer technique applicable to centrifugal microfluidic platforms. The technique involves using compressed gas to generate a pneumatic force, which works together with the centrifugal force to control and direct fluid flow. Fluid can be pneumatically transferred from chamber to chamber, greatly decreasing the number of conventional valves required in a multistep process. By varying the rotational frequency of the centrifugal microfluidic platform while pneumatic force is applied, sequential fluid transfer steps can be achieved. The effectiveness of this fluid transfer method is demonstrated by performing a standard additions calibration. This technique is shown to be robust, easy to implement, and greatly reduces the design limitations traditionally associated with centrifugal microfluidic platforms.
Unrefined Corn Oil Improves the Mycoherbicidal Activity of<i>Colletotrichum truncatum</i>for Hemp Sesbania (<i>Sesbania exaltata</i>) Control (1994)

In greenhouse experiments, unrefined corn oil was tested as an adjuvant with the mycoherbicidal fungus, Colletotrichum truncatum. A1:1 (V/V) fungus/corn oil tank mixture extended by at least 70 h the period of time in which the fungus remains infective between inoculation and the onset of dew. This formulation also reduced the dew period requirements for optimal weed pathogenesis and mortality from 12 h to 2 h, and reduced the required spray volume by 100-fold, from 500 L/ha to 5 L/ha. These results suggest that formulating C. truncatum in unrefined corn oil greatly improves the bioherbicidal potential of this pathogen.
Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and Postpartum The American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum (2011)

Pregnancy has a profound impact on the thyroid gland and thyroid function. The gland increases 10% in size during pregnancy in iodine-replete countries and by 20%– 40% in areas of iodine deficiency. Production of thyroxine (T4) and triiodothyronine (T3) increases by 50%, along with a 50% increase in the daily iodine requirement. These physiological changes may result in hypothyroidism in the later stages of pregnancy in iodine-deficient women who were euthyroid in the first trimester. The range of thyrotropin (TSH), under the impact of placental human chorionic gonadotropin (hCG), is decreased throughout pregnancy with the lower normal TSH level in the first trimester being poorly defined and an upper limit of 2.5 mIU/L. Ten percent to 20% of all pregnant women in the first trimester of pregnancy are thyroid peroxidase (TPO) or thyroglobulin (Tg) antibody positive and euthyroid. Sixteen percent of the women who are euthyroid and positive for TPO or Tg antibody in the first trimester will develop a TSH that exceeds 4.0 mIU/L by the third trimester, and 33%–50% of women who are positive for TPO or Tg antibody in the first trimester will develop postpartum thyroiditis. In essence, pregnancy is a stress test for the thyroid, resulting in hypothyroidism in women with limited thyroidal reserve or iodine deficiency, and postpartum thyroiditis in women with underlying Hashimoto’s disease who were euthyroid prior to conception. Knowledge regarding the interaction between the thyroid and pregnancy/the postpartum period is advancing at a rapid pace. Only recently has a TSH of 2.5 mIU/L been accepted as the upper limit of normal for TSH in the first trimester. This has important implications in regards to interpretation of the literature as well as a critical impact for the clinical diagnosis of hypothyroidism. Although it is well accepted that overt hypothyroidism and overt hyperthyroidism have a deleterious impact on pregnancy, studies are now focusing on the potential impact of subclinical hypothyroidism and subclinical hyperthyroidism on maternal and
Sethoxydim and Broadleaf Herbicide Interaction Effects on Annual Grass Control in Peanuts (<i>Arachis hypogaea</i>) (1991)

Control of Texas panicum and southern crabgrass with sethoxydim was reduced under field conditions when bentazon, acifluorfen, bentazon + acifluorfen, pyridate, or naptalam plus 2,4-DB was added. The addition of lactofen to sethoxydim did not result in antagonism. Complete control of annual grasses did not appear to be a necessity in order to improve peanut yields. Peanut yields in plots with 70 to 80% control of annual grasses were comparable to those where annual grass control was 99%.
Regulation of Mitochondrial Cholesterol Metabolism (1997)

Cholesterol is required for the growth and replication of mammalian cells. As an integral component of membranes, particularly the plasmalemma, cholesterol facilitates membrane curvature and increases resistance to physical damage. The insertion of cholesterol into membranes increases fluidity (Chapman, 1975), a property closely correlated with the cholesterol/phospholipid (C/PL) ratio. Cholesterol is also the substrate for the production of bile acids and steroid hormones. Because of cholesterol’s importance to cellular function, intracellular cholesterol concentrations are highly regulated (Yeagle, 1985; Lange and Ramos, 1983). Indeed, increases or decreases in this sterol can produce major alterations in cell physiology.
Activity Coefficients and Volumetric Properties for the NaBr + Maltose + Water System at 298.15 K (2005)

Activity coefficients and volumetric properties for the NaBr + maltose + water system were determined at 298.15 K by cell potential and density measurements, respectively. The activity coefficients were evaluated respectively from the cell potential data using the Debye−Hückel and the Pitzer equations, and they are in quite agreement with each other. Infinite-dilution apparent molar volumes for maltose ( ) in aqueous NaBr and those for NaBr ( ) in aqueous maltose were evaluated, respectively. Free energy and volumetric interaction parameters (gES and vES) were also obtained. These results were discussed in terms of the stereochemistry of saccharide molecules and the group additivity model.
Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells (2014)

Fifteen percent of tumors utilize recombination-based alternative lengthening of telomeres (ALT) to maintain telomeres. The mechanisms underlying ALT are unclear but involve several proteins involved in homologous recombination including the BLM helicase, mutated in Bloom's syndrome, and the BRCA1 tumor suppressor. Cells deficient in either BLM or BRCA1 have phenotypes consistent with telomere dysfunction. Although BLM associates with numerous DNA damage repair proteins including BRCA1 during DNA repair, the functional consequences of BLM-BRCA1 association in telomere maintenance are not completely understood. Our earlier work showed the involvement of BRCA1 in different mechanisms of ALT, and telomere shortening upon loss of BLM in ALT cells. In order to delineate their roles in telomere maintenance, we studied their association in telomere metabolism in cells using ALT. This work shows that BLM and BRCA1 co-localize with RAD50 at telomeres during S- and G2-phases of the cell cycle in immortalized human cells using ALT but not in cells using telomerase to maintain telomeres. Co-immunoprecipitation of BRCA1 and BLM is enhanced in ALT cells at G2. Furthermore, BRCA1 and BLM interact with RAD50 predominantly in S- and G2-phases, respectively. Biochemical assays demonstrate that full-length BRCA1 increases the unwinding rate of BLM three-fold in assays using a DNA substrate that models a forked structure composed of telomeric repeats. Our results suggest that BRCA1 participates in ALT through its interactions with RAD50 and BLM.
An experimental evaluation of the performance of two-branch space and polarization diversity schemes at 1800 MHz (1995)

Determines the mean signal level and envelope cross-correlation of 1800 MHz base station signals received in two-branch spatial and polarization diversity schemes. Measurements have been conducted with the experimental base site located in (i) two urban sites, (ii) a residential area, (iii) a rural area, and (iv) near a motorway. In each location, the effect of the random orientation of a typical mobile radio telephone handset has been studied by examining the characteristics of signals received from a mobile collinear antenna inclined at angles of 0/spl deg/, 30/spl deg/, 45/spl deg/, 60/spl deg/, and 90/spl deg/ to the vertical. Furthermore, the diversity gain at 90% signal reliability has been evaluated for each diversity scheme by simulating selection, equal-gain and maximal-ratio combining techniques using the recorded signals as inputs. Results have shown that 20/spl lambda/ separation in the horizontal plane or 15/spl lambda/ in the vertical plane is sufficient to obtain a cross-correlation of less than 0.7 for most of the time at 1800 MHz. Similar cross-correlation results were obtained for polarization diversity. When the antenna is inclined at 45/spl deg/, a 6 dB degradation in signal level was recorded for space diversity schemes. However, the diversify gain is unaffected by tilt and remains unchanged at 5-6 dB for horizontal and 3.5-4.5 dB for vertical separation. For polarization diversity, only a little degradation is experienced because most of the energy lost on the vertical branch is recovered on the horizontal branch. The diversity gain is between 1-2 dB at 0/spl deg/ tilt and increases to 3-5.2 dB at 45/spl deg/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Finite and boundary element approach to process simulation with conjugate gradient-based method (1987)

An efficient numerical scheme for obtaining the two dimensional impurity profile and structural features of the semiconductor devices is proposed. The finite element method (FEM) is used to solve the drift-diffusion equation of impurities in silicon. The thermal oxidation using a model based on steady-state oxidant diffusion is dealt with the boundary element method (BEM). Both methods are employed for calculating the complicated geometry and the boundary conditions in the simulation, where these methods are simultaneously used for the oxidizing condition. For the finite element analysis, mass lumping is introduced to get the stable result. The matrix obtained is asymmetric and irregular sparse, the matrix is solved by the Conjugate Gradient-Squared method (CGS) with preconditioning-conditioning (Incomplete LDU factorization). Thus a more economical calculation method is obtained than the conventional FEM and BEM analysis, using Gaussian elimination method.
Ester Synthesis by NAD<sup>+</sup>-dependent Dehydrogenation of Hemiacetal: Production of Methyl Formate by Cells of Methylotrophic Yeasts (1997)

A water-soluble ester, methyl formate, was detected as a metabolite in the culture medium of methylotrophic yeasts. Methyl formate synthase, which catalyses NAD(+)-dependent dehydrogenation of the hemiacetal adduct of methanol and formaldehyde, catalyses the ester synthesis. The enzyme activity was induced on a methanol medium and was increased further by the addition of formaldehyde. In the reaction system using intact cells of Pichia methanolica AKU 4262, 135 mM (8.1 g/liter) methyl formate was produced from 2 M methanol. This is a new biological process for ester synthesis that couples spontaneous formation of hemiacetal and alcohol dehydrogenase.