gebhart/patrepeval huggingface dataset:
The Landscape of <i>C. elegans</i> 3′UTRs (2010)

Three-prime untranslated regions (3'UTRs) of metazoan messenger RNAs (mRNAs) contain numerous regulatory elements, yet remain largely uncharacterized. Using polyA capture, 3' rapid amplification of complementary DNA (cDNA) ends, full-length cDNAs, and RNA-seq, we defined approximately 26,000 distinct 3'UTRs in Caenorhabditis elegans for approximately 85% of the 18,328 experimentally supported protein-coding genes and revised approximately 40% of gene models. Alternative 3'UTR isoforms are frequent, often differentially expressed during development. Average 3'UTR length decreases with animal age. Surprisingly, no polyadenylation signal (PAS) was detected for 13% of polyadenylation sites, predominantly among shorter alternative isoforms. Trans-spliced (versus non-trans-spliced) mRNAs possess longer 3'UTRs and frequently contain no PAS or variant PAS. We identified conserved 3'UTR motifs, isoform-specific predicted microRNA target sites, and polyadenylation of most histone genes. Our data reveal a rich complexity of 3'UTRs, both genome-wide and throughout development.
Progressive Age-Related Impairment of the Late Long-Term Potentiation in Alzheimer's Disease Presenilin-1 Mutant Knock-in Mice (2010)

Presenilin 1 (PS1) mutations are responsible for many early-onset familial Alzheimer's disease (FAD) cases. While increasing evidence points to impaired synaptic plasticity as an early event in AD, PS1 mutant mice exhibit a paradoxical increase in hippocampal long-term potentiation (LTP). Among PS1 mouse models, PS1 M146V mutant knock-in mice (PS1KI) are particularly interesting in that they exhibit memory impairment in spatial tasks. Here we investigated the effects of aging on two forms of LTP in PS1KI mice, the widely-studied early phase of LTP (E-LTP) and a particular form of LTP called late-LTP (L-LTP) which requires transcription and protein synthesis. L-LTP is thought to be critical for long-term memory. We found a lower L-LTP maintenance phase in PS1KI mice compared to wild type littermates at 3 months of age. As the mice age, they exhibit impairment of both the induction and maintenance phases of LTP. When E-LTP and NMDA receptor-mediated transmission were analyzed, PS1KI mice displayed an increase at 3 months compared to wild type littermates; this difference did not persist at older ages and finally decreased at 12 months. These results reveal an L-LTP decrease in PS1 mutant mice at an early stage, which occurs coincidently with a paradoxical enhancement of E-LTP. The observation of a decrease in both forms of LTP during aging supports the view that PS1KI mice are a valuable model for the study of age-dependent synaptic dysfunction and cognitive decline in AD.
A New Agenda for APEC: Setting Up the 'Building Blocks' of Free Trade (1994)

For more about the East-West Center, see <a href="http://www.eastwestcenter.org/">http://www.eastwestcenter.org/</a>
Percutaneous Collagen Induction Therapy: An Alternative Treatment for Scars, Wrinkles, and Skin Laxity (2008)

Percutaneous collagen induction was started in 1997 and has proved to be a simple and fast method for safely treating wrinkles and scars. As opposed to ablative laser treatments, the epidermis remains intact and is not damaged. For this reason, the procedure can be repeated safely and is also suited to regions where laser treatments and deep peels cannot be performed.
Explaining First Impressions: Modeling, Recognizing, and Explaining Apparent Personality from Videos (2018)

Explainability and interpretability are two critical aspects of decision support systems. Within computer vision, they are critical in certain tasks related to human behavior analysis such as in health care applications. Despite their importance, it is only recently that researchers are starting to explore these aspects. This paper provides an introduction to explainability and interpretability in the context of computer vision with an emphasis on looking at people tasks. Specifically, we review and study those mechanisms in the context of first impressions analysis. To the best of our knowledge, this is the first effort in this direction. Additionally, we describe a challenge we organized on explainability in first impressions analysis from video. We analyze in detail the newly introduced data set, the evaluation protocol, and summarize the results of the challenge. Finally, derived from our study, we outline research opportunities that we foresee will be decisive in the near future for the development of the explainable computer vision field.
Fish oil supplementation enhanced CPT-11 (irinotecan) efficacy against MCF7 breast carcinoma xenografts and ameliorated intestinal side-effects (1999)

The cancer chemotherapeutic efficacy of the topoisomerase I inhibitor, CPT-11 (irinotecan) is often limited by the induction of severe delayed diarrhoea. In animal studies, CPT-11 use is associated with histopathological damage to the mucosa of the small and large intestines. Results from the present study demonstrate that 60 mg CPT-11 per kg body weight (i.v. q4d x 6) halted the growth, but did not cause significant regression, of MCF7 human breast carcinoma xenografts in mice fed a diet containing 7% corn oil. However, when the diet of the MCF7-bearing mice was supplemented with 3% or 6% fish oil, the same CPT-11 treatment caused significant regression of the MCF7 xenograft. Histomorphometric analyses of intestinal mucosa of mice treated with CPT-11 and fed the diet containing 7% com oil indicated that treatment with CPT-11 induced structural changes in the intestinal mucosa which persisted at least 5 days after the last dose of CPT-11. The intestinal mucosal architecture of mice that were treated with CPT-11 and fed the diets containing fish oil was largely unchanged from the architecture of the group of mice which did not receive CPT-11. These findings indicate that fish oil supplements may be a useful adjunct to CPT-11 treatment.
Understanding and Using the Implicit Association Test: II. Method Variables and Construct Validity (2004)

The Implicit Association Test (IAT) assesses relative strengths of four associations involving two pairs of contrasted concepts (e.g., male-female and family-career). In four studies, analyses of data from 11 Web IATs, averaging 12,000 respondents per data set, supported the following conclusions: (a) sorting IAT trials into subsets does not yield conceptually distinct measures; (b) valid IAT measures can be produced using as few as two items to represent each concept; (c) there are conditions for which the administration order of IAT and self-report measures does not alter psychometric properties of either measure; and (d) a known extraneous effect of IAT task block order was sharply reduced by using extra practice trials. Together, these analyses provide additional construct validation for the IAT and suggest practical guidelines to users of the IAT.
Segmentation and Word Spotting Methods for Printed and Handwritten Arabic Texts: A Comparative Study (2012)

This paper presents a comparative study for word spotting techniques according to holistic approach. So, the current work consists in experimenting word image segmentation, characterization and matching to show the most reliable techniques. The experimental process is done in the same printed and handwritten Arabic dataset. Our aim is to realize an effective system of information retrieval.
Synthesis of an optically active .alpha.-aminophosphonic acid (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of an optically active .alpha.-aminophosphonic acidW. Franklin Gilmore and Hilmer A. McBrideCite this: J. Am. Chem. Soc. 1972, 94, 12, 4361Publication Date (Print):June 1, 1972Publication History Published online1 May 2002Published inissue 1 June 1972https://pubs.acs.org/doi/10.1021/ja00767a065https://doi.org/10.1021/ja00767a065research-articleACS PublicationsRequest reuse permissionsArticle Views367Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Music Based Harmony Search (MBHS) approach to Optimal Power Flow with reactive power loss optimization (2010)

This paper presents a new optimization algorithm, Music Based Harmony Search (MBHS) applied to the Optimal Power flow (OPF) problem with line constraints for minimizing the Fuel costs together with Generator Reactive power losses. The proposed method is compared with other optimization techniques like Simple Genetic Algorithm (SGA), Adaptive Genetic Algorithm (AGA) and Particle Swarm Optimization (PSO) to prove its supremacy. The algorithm is tested on a standard IEEE 30 bus test bed and numerous analyses viz., the effect on taps; shunt reactors etc., with different MBHS parameters are demonstrated. It is found that MBHS offers a computationally faster (75.83 times) and robust solution for OPF problem.
Research on the Problem of Translating Natural Language Sentences into Algebra (2015)

N/A
Applying QR Code in Mobile Banking Use (2021)

The QR technology has changed the payment industry especially in retail market. More and more companies introduce their easy payment through QR payment. The fast penetration in the market has made QR payment become necessary payment for major SME industries to survive in the market. QR payment has become essential substitution to current cash or debit card payment. Although QR payment has convenience experience, it poses to security threats associated with its system design. Many mobile applications still have many difficulties to balance to adopt its benefits and managing threats. The article takes case study of a well-known banking mobile banking application in applying QR system. The outcome of the article is expected to provide reference for mobile application to apply QR system.
Development of a technique for separating Raman scattering signals from background emission with single-shot measurement potential (1997)

Raman scattering is a powerful technique for quantitatively probing high temperature and high speed flows. However, this technique has typically been limited to clean hydrogen flames because of the broadband fluorescence interference which occurs in hydrocarbon flames. Fluorescence can also interfere with the Raman signal in clean hydrogen flames when broadband UV lasers are used as the scattering source. A solution to this problem has been demonstrated. The solution to the fluorescence interference lies in the fact that the vibrational Q-branch Raman signal is highly polarized for 90 deg. signal collection and the fluorescence background is essentially unpolarized. Two basic schemes are available for separating the Raman from the background. One scheme involves using a polarized laser and collecting a signal with both horizontal and vertical laser polarizations separately. The signal with the vertical polarization will contain both the Raman and the fluorescence while the signal with the horizontal polarization will contain only the fluorescence. The second scheme involves polarization discrimination on the collection side of the optical setup. For vertical laser polarization, the scattered Q-branch Raman signal will be vertically polarized; hence the two polarizations can be collected separately and the difference between the two is the Raman signal. This approach has been used for the work found herein and has the advantage of allowing the data to be collected from the same laser shot(s). This makes it possible to collect quantitative Raman data with single shot resolution in conditions where interference cannot otherwise be eliminated.
Kinetics of Soluble Chromium Removal from Contaminated Water by Zerovalent Iron Media:  Corrosion Inhibition and Passive Oxide Effects (2001)

Permeable reactive barriers containing zerovalent iron are being increasingly employed for in situ remediation of groundwater contaminated with redox active metals and chlorinated organic compounds. This research investigated the effect of chromate concentration on its removal from solution by zerovalent iron. Removal rates of aqueous Cr(VI) by iron wires were measured in batch experiments for initial chromium concentrations ranging from 100 to 10 000 microg/L. Chromate removal was also measured in columns packed with zerovalent iron filings over this same concentration range. Electrochemical measurements were made to determine the free corrosion potential and corrosion rate of the iron reactants. In both the batch and column reactors, absolute rates of chromium removal declined with increasing chromate concentration. Corrosion current measurements indicated that the rate of iron corrosion decreased with increasing Cr(VI) concentrations between 0 and 5000 microg/L. At a Cr(VI) concentration of 10 000 microg/L, Tafel polarization diagrams showed that chromium removal was affected by its diffusion rate through a passivating oxide film and by the ability of iron to release Fe2+ at anodic sites. In contrast, water reduction was not mass transfer limited, but chromium did decrease the exchange current for the hydrogen evolution reaction. Even at the most passivating concentration of 10 000 microng/L, effluent Cr(VI) concentrations in the column reactors reached a steady state, indicating that passivation had also reached a steady state. Although chromate contributes to iron surface passivation, the removal rates are still sufficiently fast for in situ iron barriers to be effective for Cr(VI) removal at most environmentally relevant concentrations.
Enhanced Rotational Invariant Fingerprint Matching Al-gorithm based on Minutiae (2013)

Fingerprint characterstic of every human are unique and stable, therefore widely accepted for personal identification. Online and real time applications require minimum response time for the matching process. In this paper an enhanced algorithm is introduced to make the matching prcess rotational invariant.The proposed algorithm is robust to match two identical fingerprint images which are spatially aligned at different rotational angles and gives better FMR and FNMR ratio for images rotated at different angles.
Automatic Equalized Data Modem. (1969)

The objective of this contract was the development and construction of an experimental model of an automatically equalized data modem of full duplex design capable of operation over nominal Schedule 4B (now Schedule C2) telephone voice circuits at rates of 1200, 2400 or 4800 bits/sec. The use of a feedback channel was not allowed. When completed the modem was tested over simulated and leased Schedule 4B telephone circuits and met or exceeded bit error rates required by the contract. The modem was also tested over simulated Schedule 4 and 4A lines with excellent results. (Author)
Small-Molecule Drugs Mimicking DNA Damage: A New Strategy for Sensitizing Tumors to Radiotherapy (2009)

These data validate the concept of introducing small DNA molecules, which mimic DNA damage, to trigger "false" signaling of DNA damage and impair DNA repair of damaged chromosomes. This new strategy could provide a new method for enhancing radiotherapy efficiency in radioresistant tumors.
Effects of Extracellular DNA on Plasminogen Activation and Fibrinolysis (2011)

The increased levels of extracellular DNA found in a number of disorders involving dysregulation of the fibrinolytic system may affect interactions between fibrinolytic enzymes and inhibitors. Double-stranded (ds) DNA and oligonucleotides bind tissue-(tPA) and urokinase (uPA)-type plasminogen activators, plasmin, and plasminogen with submicromolar affinity. The binding of enzymes to DNA was detected by EMSA, steady-state, and stopped-flow fluorimetry. The interaction of dsDNA/oligonucleotides with tPA and uPA includes a fast bimolecular step, followed by two monomolecular steps, likely indicating slow conformational changes in the enzyme. DNA (0.1-5.0 μg/ml), but not RNA, potentiates the activation of Glu- and Lys-plasminogen by tPA and uPA by 480- and 70-fold and 10.7- and 17-fold, respectively, via a template mechanism similar to that known for fibrin. However, unlike fibrin, dsDNA/oligonucleotides moderately affect the reaction between plasmin and α(2)-antiplasmin and accelerate the inactivation of tPA and two chain uPA by plasminogen activator inhibitor-1 (PAI-1), which is potentiated by vitronectin. dsDNA (0.1-1.0 μg/ml) does not affect the rate of fibrinolysis by plasmin but increases by 4-5-fold the rate of fibrinolysis by Glu-plasminogen/plasminogen activator. The presence of α(2)-antiplasmin abolishes the potentiation of fibrinolysis by dsDNA. At higher concentrations (1.0-20 μg/ml), dsDNA competes for plasmin with fibrin and decreases the rate of fibrinolysis. dsDNA/oligonucleotides incorporated into a fibrin film also inhibit fibrinolysis. Thus, extracellular DNA at physiological concentrations may potentiate fibrinolysis by stimulating fibrin-independent plasminogen activation. Conversely, DNA could inhibit fibrinolysis by increasing the susceptibility of fibrinolytic enzymes to serpins.
<title>MODIS stray light simulation</title> (1996)

The moderate resolution imaging spectroradiometer (MODIS) will be one of the primary instruments observing the earth on the Earth Observing System (EOS) scheduled for launch at the end of this decade. Its 36 spectral bands ranging from 0.4 to 14.4 microns will image the entire earth. The radiometric requirements are such that the contributions to the optical point spread function from optical ghosts, scattered light and cross-talk in the very small spectral filters, located near the focal planes, must be characterized very well and kept to a minimum. This paper describes a series of Monte Carlo simulations of the propagation of light through the optics in order to determine the extent of the ghosting and scattered light. These results are also compared with experimental data.
The Measurement of Linear Chroma Distortion in NTSC TV Facilities (1972)

The concept of linear chroma distortion permits us to express in numbers the subjective quality of the color in a TV picture. The MOD 12.5T pulse is the signal with which these distortions can be measured. The MOD 12.5T pulse, with its composition and frequency spectrum, is presented, together with measurement methods for the relative chroma level (RCL) and the relative chroma time (RCT).
Erratum: Sequence Space Localization in the Immune System Response to Vaccination and Disease [Phys. Rev. Lett.<b>91</b>, 068101 (2003) (2003)

Received 21 August 2003DOI:https://doi.org/10.1103/PhysRevLett.91.229902©2003 American Physical Society
Cancer-Selective Targeting and Cytotoxicity by Liposomal-Coupled Lysosomal Saposin C Protein (2009)

Saposin C-dioleoylphosphatidylserine nanovesicles offer promise as a novel, nontoxic, cancer-targeted, antitumor agent for treating a broad range of cancers.
Theoretical Performance Analysis of Metal Hydride Fuel Additives for Rocket Propellant Applications (2011)

Metal hydrides gained interest as propellant additives in the 1960s, but were dismissed due to their sensitive nature. Recently, the main focus of metal hydride research has been on their use in hydrogen storage, but due to advancements in material synthesis, processing, stabilization and handling, their use as a propellant additive is being revisited. A comprehensive theoretical performance investigation was conducted to determine the affect of metal hydride additives on the performance of both hybrid and liquid propellants. Thermo-chemistry equilibrium calculations were performed to produce theoretical rocket performance properties for each propellant formulation. Dicyclopentadiene (DCPD) and RP-1 were chosen as the hybrid and bi-propellant fuels that would be augmented by the metal hydrides. These fuels were selected for their ability to prevent material dehydrogenation and degradation. The use of specific metal hydride fuel additives is shown to raise a propellant formulation’s overall specific impulse, by as much as 17% when beryllium hydride is considered. Other metal hydrides, such as alane and lithium aluminum hydride, increase propellant specific impulse by approximately 4%. Density specific impulse is seen to increase by 6% and 7% with zirconium hydride and titanium hydride, respectively. By examining each formulation’s performance dependence on its hydrogen content it is revealed that specific impulse tends to increase with volumetric hydrogen density and gravimetric hydrogen content. Density specific impulse on the other hand tends to increase with volumetric hydrogen density, but decrease with increased gravimetric hydrogen content.
Bottom-up approach for microstructure optimization of sound absorbing materials (2008)

Results from a numerical study examining micro-/macrorelations linking local geometry parameters to sound absorption properties are presented. For a hexagonal structure of solid fibers, the porosity phi, the thermal characteristic length Lambda('), the static viscous permeability k(0), the tortuosity alpha(infinity), the viscous characteristic length Lambda, and the sound absorption coefficient are computed. Numerical solutions of the steady Stokes and electrical equations are employed to provide k(0), alpha(infinity), and Lambda. Hybrid estimates based on direct numerical evaluation of phi, Lambda('), k(0), alpha(infinity), Lambda, and the analytical model derived by Johnson, Allard, and Champoux are used to relate varying (i) throat size, (ii) pore size, and (iii) fibers' cross-section shapes to the sound absorption spectrum. The result of this paper tends to demonstrate the important effect of throat size in the sound absorption level, cell size in the sound absorption frequency selectivity, and fibers' cross-section shape in the porous material weight reduction. In a hexagonal porous structure with solid fibers, the sound absorption level will tend to be maximized with a 48+/-10 microm throat size corresponding to an intermediate resistivity, a 13+/-8 microm fiber radius associated with relatively small interfiber distances, and convex triangular cross-section shape fibers allowing weight reduction.