gebhart/patrepeval huggingface dataset:
Influence of the type of factor VIII concentrate on the incidence of factor VIII inhibitors in previously untreated patients with severe hemophilia A (2005)

Inhibitor development is the major treatment complication in children with severe hemophilia A. It is not clear whether the risk of inhibitors is higher with recombinant factor VIII or with plasma-derived factor VIII. We used multivariate analysis to compare 2 cohorts of previously untreated patients (PUPs) with severe hemophilia A: 62 patients treated with the same brand of high-purity plasma-derived FVIII (pFVIII) containing von Willebrand factor (VWF) and 86 patients treated with full-length recombinant FVIII (rFVIII). In addition to the usual end points (all inhibitors, high inhibitors), we also examined a third end point (high inhibitors and/or immune tolerance induction). The risk of inhibitor development was higher in patients treated with rFVIII than in patients treated with pFVIII, regardless of other risk factors (F8 genotype; nonwhite origin; history of inhibitors in patients with a family history of hemophilia; age at first FVIII infusion). The adjusted relative risk (RRa) for inhibitor development with rFVIII versus pFVIII was 2.4 (all inhibitors), 2.6 (high inhibitors), and 3.2 (high inhibitors and/or immune tolerance induction), respectively, depending on the end point (above). The pathophysiology of this large effect must be understood in order to improve the characteristics of recombinant products and to reduce the incidence of inhibitors to FVIII.
Biosynthesis of Storage Proteins in Developing Rice Seeds (1982)

Sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis of the starchy endosperm protein of rice (Oryza sativa L. Japonica cv Koshihikari) during seed development confirmed that storage protein begins to accumulate about 5 days after flowering. Two polypeptide groups, 22 to 23 and 37 to 39 kilodaltons, the components of glutelin, the major storage protein in rice seed, appeared 5 days after flowering. A 26-kilodalton polypeptide, the globulin component, also appeared 5 days after flowering. Smaller polypeptides (10- to 16-kilodaltons) including prolamin components, appeared about 10 days after flowering. In contrast, the levels of the 76- and 57-kilodalton polypeptides were fairly constant throughout seed development. Transmission electron microscopy and fractionation by sucrose density gradient centrifugation of the starchy endosperms at various stages of development showed that protein body type II, the accumulation site of glutelin and globulin, was formed faster than protein body type I, the accumulation site of prolamin.The 57-kilodalton polypeptide but not the glutelin subunits was labeled in a 2-hour treatment with [(14)C]leucine given between 4 and 12 days after flowering to developing ears. In vivo pulse-chase labeling studies showed the 57-kilodalton polypeptide to be a precursor of the 22 to 23 and 37 to 39 kilodalton subunits. The 57-kilodalton polypeptide was salt-soluble, but the mature glutelin subunits were almost salt insoluble.In vitro protein synthesis also showed that the mRNAs directly coding the 22 to 23 and 37 to 39 kilodalton components were absent in developing seeds and that the 57-kilodalton polypeptide was the major product. Thus, it was concluded that the two subunits of rice glutelin are formed through post-translational cleavage of the 57-kilodalton polypeptide.
Increased resistance to cationic antimicrobial peptide LL-37 in methicillin-resistant strains of Staphylococcus aureus (2008)

Clinical strains of MRSA, but not MSSA, that demonstrated an increased net charge also showed elevated resistance to LL-37, but not to hBD3.
<i>Salmonella choleraesuis</i> as an anticancer agent in a syngeneic model of orthotopic hepatocellular carcinoma (2007)

Some anaerobic and facultative anaerobic bacteria represent novel therapeutic agents that have been recently applied in cancer therapy. Previously, we found that Salmonella choleraesuis in combination with cisplatin could retard tumor growth in the murine subsutaneous hepatocellular carcinoma (HCC) model. In this regard, we investigated the antitumor activity of S. choleraesuis in the ML-1 orthotopic tumor model. Systemically administered S. choleraesuis accumulated within not only subcutaneous but also orthotopic tumors for at least 30 days, forming tumor-to-normal tissue ratios exceeding 1,000-10,000 to 1. The antitumor effects of S. choleraesuis were evaluated in mice bearing subcutaneous and orthotopic ML-1 tumors. Compared with the control treatment, S. choleraesuis significantly prolonged the animal survival, reduced the tumor size, as well as upregulated interferon (IFN)-gamma and induced IFN-inducible chemokines CXCL10 (IP-10) productions. Furthermore, immunohistochemical staining of the tumors revealed decreased intratumoral microvessel density, increased infiltration of neutrophils, CD4(+) and CD8(+) T cells, and induced cell death in tumor microenvironment. In conclusion, these results suggest that tumor-targeted therapy using S. choleraesuis, which exerts tumoricidal and antiangiogenic activities, represents a potential strategy for the treatment of HCC.
D<scp>ockground</scp> resource for studying protein–protein interfaces (2006)

DOCKGROUND is available at http://dockground.bioinformatics.ku.edu. The current first release implements the bound-bound part.
Plasticizers from Lactic Esters and Dibasic Acids (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPlasticizers from Lactic Esters and Dibasic AcidsC. E. Rehberg, T. J. Dietz, P. E. Meiss, and Marion B. DixonCite this: Ind. Eng. Chem. 1952, 44, 9, 2191–2195Publication Date (Print):September 1, 1952Publication History Published online1 May 2002Published inissue 1 September 1952https://pubs.acs.org/doi/10.1021/ie50513a058https://doi.org/10.1021/ie50513a058research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The contour of an optimal field plate-an analytical approach (1988)

An analytical relationship has been developed to calculate the field distribution at the semiconductor surface of an MOS structure with a finite rectangular metal electrode for the deep depletion mode. This relationship has been verified using two-dimensional numerical calculations. A further result of this model is a formula for the contour of an optimal field electrode.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Extending the Field of View With Phased Array Techniques: Results of European SKA Research (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The radio frequency window of the Square Kilometre Array is planned to cover the wavelength regime from centimeters up to a few meters. For this range to be optimally covered, different antenna concepts are considered. At the lowest frequency range, up to a few gigahertz, it is expected that multibeam techniques will be used, increasing the effective field-of-view to a level that allows very efficient detailed and sensitive exploration of the complete sky. Although sparse narrow-band phased arrays are as old as radio astronomy, multioctave sparse and dense arrays now considered for the SKA require new low-noise design, signal processing, and calibration techniques. The successful implementation of these new array techniques has already been introduced for the use of phased array feeds upgrading existing telescopes: enhancing aperture efficiency as well as effective field-of-view. Especially the development of low-cost array antenna design will allow a cost-effective large-scale implementation for the SKA. This paper addresses these new capabilities, emphasizing the R&D work done in Europe and aims to provide insight into the status of enabling technologies and technical research on polarization, calibration, and side-lobe control that will unleash the potential of phased arrays for future growth of radio astronomy synthesis arrays. </para>
The development of a prototype aircraft-height monitoring unit utilising an SSR-based difference in time of arrival technique (1992)

The authors describe a method of monitoring the geometric height of aircraft using an SSR-based radar technique. A research and development project is currently being carried out by Roke Manor Research and the UK National Air Traffic Services on behalf of Eurocontrol. Knowledge of the true target height of aircraft will assist in the establishment and maintenance of reduced vertical separation margin (RVSM) airspace for aircraft flying at FL290 (29000 ft) and above, providing more efficient use of airspace.
Fragments of HdhQ150 Mutant Huntingtin Form a Soluble Oligomer Pool That Declines with Aggregate Deposition upon Aging (2012)

Cleavage of the full-length mutant huntingtin (mhtt) protein into smaller, soluble aggregation-prone mhtt fragments appears to be a key process in the neuropathophysiology of Huntington's Disease (HD). Recent quantification studies using TR-FRET-based immunoassays showed decreasing levels of soluble mhtt correlating with an increased load of aggregated mhtt in the aging HdhQ150 mouse brain. To better characterize the nature of these changes at the level of native mhtt species, we developed a detection method that combines size exclusion chromatography (SEC) and time-resolved fluorescence resonance energy transfer (TR-FRET) that allowed us to resolve and define the formation, aggregation and temporal dynamics of native soluble mhtt species and insoluble aggregates in the brain of the HdhQ150 knock-in mouse. We found that mhtt fragments and not full-length mhtt form oligomers in the brains of one month-old mice long before disease phenotypes and mhtt aggregate histopathology occur. As the HdhQ150 mice age, brain levels of soluble full-length mhtt protein remain similar. In contrast, the soluble oligomeric pool of mhtt fragments slightly increases during the first two months before it declines between 3 and 8 months of age. This decline inversely correlates with the formation of insoluble mhtt aggregates. We also found that the pool-size of soluble mhtt oligomers is similar in age-matched heterozygous and homozygous HdhQ150 mouse brains whereas insoluble aggregate formation is greatly accelerated in the homozygous mutant brain. The capacity of the soluble mhtt oligomer pool therefore seems exhausted already in the heterozygous state and likely kept constant by changes in flux and, as a consequence, increased rate of insoluble aggregate formation. We demonstrate that our novel findings in mice translate to human HD brain but not HD patient fibroblasts.
Multimodal natural user interaction for multiple applications: The gesture &#x2014; Voice example (2012)

In this paper we present a natural user interface system. The device utilized for achieving natural interaction is the MS-Kinect which provides RGB, depth & audio signal. Our system is based on the theory of multimodal interaction and provides the ability to the user to interact simultaneously with different applications using vocal commands and gesture in conjunction. The difference of our system from other similar efforts is that it uses a multimodal interaction approach to manipulate multi-applications by employing a generic container, which runs at the background and serves as an intermediate between multimodal input and active applications running on a computer. We describe the architecture of the system based on multimodal interaction and its representative example using two PC applications.
Time-optimal Trajectories for an Omni-directional Vehicle (2006)

A common mobile robot design consists of three ‘omniwheels’ arranged at the vertices of an equilateral triangle, with wheel axles aligned with the rays from the center of the triangle to each wheel. Omniwheels, like standard wheels, are driven by the motors in a direction perpendicular to the wheel axle, but unlike standard wheels, can slip in a direction parallel to the axle. Unlike a steered car, a vehicle with this design can move in any direction without needing to rotate first, and can spin as it does so. The shortest paths for this vehicle are straight lines. However, the vehicle can move more quickly in some directions than in others. What are the fastest trajectories? We consider a kinematic model of the vehicle and place independent bounds on the speeds of the wheels, but do not consider dynamics or bound accelerations. We derive the analytical fastest trajectories between configurations. The time-optimal trajectories contain only spins in place, circular arcs, and straight lines parallel to the wheel axles. We classify optimal trajectories by the order and type of the segments; there are four such classes, and there are no more than 18 control switches in any optimal trajectory.
The Impossibility of Pseudo-Telepathy Without Quantum Entanglement (2002)

Imagine that Alice and Bob, unable to communicate, are both given a 16-bit string such that the strings are either equal, or they differ in exactly 8 positions. Both parties are then supposed to output a 4-bit string in such a way that these short strings are equal if and only if the original longer strings given to them were equal as well. It is known that this task can be fulfilled without failure and without communication if Alice and Bob share 4 maximally entangled quantum bits. We show that, on the other hand, they CANNOT win the same game with certainty if they only share classical bits, even if it is an unlimited number. This means that for fulfilling this particular distributed task, quantum entanglement can completely replace communication. This phenomenon has been called pseudo-telepathy. The results of this paper complete the analysis of the first proposed game of this type between two players.
Kallikrein-Related Peptidase 7 Promotes Multicellular Aggregation via the α5β1 Integrin Pathway and Paclitaxel Chemoresistance in Serous Epithelial Ovarian Carcinoma (2010)

Kallikrein-related peptidase 7 (KLK7) is upregulated in epithelial ovarian carcinoma (EOC) with high levels correlated with poor prognosis. However, the mechanisms underlying this relationship and the role of KLK7 in EOC progression are unknown. We report that two different KLK7 transcripts, KLK7-253 and KLK7-181, are simultaneously expressed in high-grade serous EOC. Multicellular aggregates (MCA), which promote cell survival and chemoresistance, were observed in SKOV-3 cells stably overexpressing KLK7-253 in particular. Importantly, these MCAs invade into a monolayer of mesothelial cells and form cancer cell foci. Blocking MCA using antibodies against KLK7 and alpha(5)beta(1) and beta(1) integrins confirmed the involvement of KLK7 and integrin-regulated cell adhesion. Increased levels of alpha(5)/beta(1) integrins and enhanced attachment to fibronectin and vitronectin, which was blocked with an anti-beta(1) integrin antibody, were also observed. Finally, Western blot and immunohistochemistry showed higher KLK7 and alpha(5)/beta(1) integrin levels in serous EOC cells from ascites and tumor samples from chemotherapy nonresponders with short postsurvival times. Additionally, both KLK7-253 and KLK7-181 clones were more resistant to paclitaxel treatment in vitro. These findings suggest a mechanism for the association of high KLK7 levels with chemoresistance and poor prognosis for serous EOC patients by promotion of peritoneal dissemination and reinvasion via increased MCA and alpha(5)beta(1) integrin-dependent cell adhesion.
Thermal Management Architecture for Future Responsive Spacecraft (2009)

This paper describes a novel thermal design architecture that enables satellites to be conceived, configured, launched, and operationally deployed very quickly. The architecture has been given the acronym SMARTS for Satellite Modular and Reconfigurable Thermal System and it involves four basic design rules: modest radiator oversizing, maximum external insulation, internal isothermalization and radiator heat flow modulation. The SMARTS philosophy is being developed in support of the DoD Operationally Responsive Space (ORS) initiative which seeks to drastically improve small satellite adaptability, deployability, and design flexibility. To illustrate the benefits of the philosophy for a prototypical multi‐paneled small satellite, the paper describes a SMARTS thermal control system implementation that uses: panel‐to‐panel heat conduction, intra‐panel heat pipe isothermalization, radiator heat flow modulation via a thermoelectric cooler (TEC) cold‐biased loop heat pipe (LHP) and maximum external multi‐layer insulation (MLI). Analyses are presented that compare the traditional “cold‐biasing plus heater power” passive thermal design approach to the SMARTS approach. Plans for a 3‐panel SMARTS thermal test bed are described. Ultimately, the goal is to incorporate SMARTS into the design of future ORS satellites, but it is also possible that some aspects of SMARTS technology could be used to improve the responsiveness of future NASA spacecraft. [22 CFR 125.4(b)(13) applicable]
The 1999 ICFP programming contest (2000)

article Free Access Share on The 1999 ICFP programming contest Authors: Norman Ramsey Harvard University Harvard UniversityView Profile , Kevin Scott University of Virginia University of VirginiaView Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 35Issue 3March 2000 pp 73–83https://doi.org/10.1145/351159.351178Online:01 March 2000Publication History 1citation179DownloadsMetricsTotal Citations1Total Downloads179Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
HIV-1 Tat Peptide Immunoconjugates Differentially Sensitize Breast Cancer Cells to Selected Antiproliferative Agents That Induce the Cyclin-Dependent Kinase Inhibitor p21<sup>WAF-1/CIP-1</sup> (2006)

In this study, we evaluated the ability of anti-p21 antibodies conjugated to 17-mer peptides [GRKKRRQRRRPPQGYGC] harboring the membrane-translocating and nuclear import sequences [underlined] of HIV-1 tat protein to inhibit the cyclin-dependent kinase inhibitor, p21(WAF-1/Cip-1) (p21) and differentially sensitize MDA-MB-468 and MCF-7 human breast cancer (BC) cells to the antiproliferative effects of treatments that induce or do not induce p21. BC cells were treated with increasing concentrations of epidermal growth factor (EGF; 0.5-10 nM), the topoisomerase I inhibitor, camptothecin (CPT; 0.1-4 muM), or increasing doses of gamma-radiation (2-20 Gy). Western blot was used to evaluate p21 expression. The effect of treatment on cell cycle distribution was studied. Growth inhibition was measured by the WST-1 assay. Expression of p21 was increased in MDA-MB-468 cells treated with EGF or CPT but not by gamma-irradiation. MCF-7 cells exhibited p21 upregulation following exposure to CPT and gamma-radiation but not EGF. EGF caused cell cycle arrest in G(1) phase for MDA-MB-468 cells. CPT caused G(1)-phase arrest in MDA-MB-468 cells and prolonged S phase in MCF-7 cells. gamma-Radiation caused an increase in cells in G(2)/M phase for MDA-MB-468 and MCF-7. MDA-MB-468 cells were growth-inhibited by EGF, CPT, and gamma-radiation. MCF-7 cells were growth-stimulated by EGF and inhibited by CPT and gamma-radiation. Combining EGF with tat-anti-p21 immunoconjugates (ICs) amplified the growth-inhibitory effect on MDA-MB-468 cells 1.2-fold to 2.3-fold, but had no effect on the growth stimulation of MCF-7 cells by EGF. Tat-anti-p21 ICs sensitized MCF-7 cells 1.4-fold to gamma-radiation but had no effect on the growth of gamma-irradiated MDA-MB-468 cells. Tat-anti-p21 ICs sensitized both MDA-MB-468 and MCF-7 cells 1.7-fold to CPT. We conclude that tat-anti-p21 ICs are promising sensitizers for cytotoxic cancer therapies and that their sensitization is dependent on treatment-related p21 expression. This general approach could potentially be extended to other growth-regulatory molecules that are associated with tumor growth and progression.
Dynamic Power Supply Current Testing for Open Defects in CMOS SRAMs (2001)

The detection of open defects in CMOS SRAM has been a time consuming process. This paper proposes a new dynamic power supply current testing method to detect open defects in CMOS SRAM cells. By monitoring a dynamic current pulse during a transition write operation or a read operation, open defects can be detected. In order to measure the dynamic power supply current pulse, a current monitoring circuit with low hardware overhead is developed. Using the sensor, the new testing method does not require any additional test sequence. The results show that the new test method is very efficient compared with other testing methods. Therefore, the new testing method is very attractive.
Ultrasonic imaging of subsurface objects using photorefractive dynamic holography (2001)

The INEEL has developed a photorefractive ultrasonic imaging technology that records both phase and amplitude of ultrasonic waves on the surface of solids. Phase locked dynamic holography provides full field images of these waves scattered from subsurface defects in solids, and these data are compared with theoretical predictions. Laser light reflected by a vibrating surface is imaged into a photorefractive material where it is mixed in a heterodyne technique with a reference wave. This demodulates the data and provides an image of the ultrasonic waves in either 2 wave or 4 wave mixing mode. These data images are recorded at video frame rates and show phase locked traveling or resonant acoustic waves. This technique can be used over a broad range of ultrasonic frequencies. Acoustic frequencies from 2 kHz to 10 MHz have been imaged, and a point measuring (non-imaging) version of the system has measured picometer amplitudes at 1 Ghz.
A class-based language model for large-vocabulary speech recognition extracted from part-of-speech statistics (1999)

A novel approach is presented to class-based language modeling based on part-of-speech statistics. It uses a deterministic word-to-class mapping, which handles words with alternative part-of-speech assignments through the use of ambiguity classes. The predictive power of word-based language models and the generalization capability of class-based language models are combined using both linear interpolation and word-to-class backoff, and both methods are evaluated. Since each word belongs to one precisely ambiguity class, an exact word-to-class backoff model can easily be constructed. Empirical evaluations on large-vocabulary speech-recognition tasks show perplexity improvements and significant reductions in word error-rate.