gebhart/patrepeval huggingface dataset:
Buried heterostructure quantum cascade lasers with high continuous-wave wall plug efficiency (2007)

The authors report on the development of λ∼4.7μm strain-balanced InP-based quantum cascade lasers with high wall plug efficiency and room temperature continuous-wave operation. The use of narrow-ridge buried heterostructure waveguides and thermally optimized packaging is presented. Over 9.3% wall plug efficiency is reported at room temperature from a single device producing over 0.675W of continuous-wave output power. Wall plug efficiencies greater than 18% are also reported for devices at a temperature of 150K, with continuous-wave output powers of more than 1W.
CBAM: Convolutional Block Attention Module (2018)

We propose Convolutional Block Attention Module (CBAM), a simple yet effective attention module for feed-forward convolutional neural networks. Given an intermediate feature map, our module sequentially infers attention maps along two separate dimensions, channel and spatial, then the attention maps are multiplied to the input feature map for adaptive feature refinement. Because CBAM is a lightweight and general module, it can be integrated into any CNN architectures seamlessly with negligible overheads and is end-to-end trainable along with base CNNs. We validate our CBAM through extensive experiments on ImageNet-1K, MS~COCO detection, and VOC~2007 detection datasets. Our experiments show consistent improvements in classification and detection performances with various models, demonstrating the wide applicability of CBAM. The code and models will be publicly available.
Ileal resection-induced gallstones: altered bilirubin or cholesterol metabolism? (1984)

Ileal resection has been shown to increase the risk of cholelithiasis. Earlier studies in humans suggested that ileal resection increases the cholesterol saturation index. Recent data from patients on long-term parenteral nutrition and from animals, however, have suggested that ileal resection predisposes to pigment gallstone formation. We therefore tested the hypothesis that ileal resection alters bile calcium and bilirubin metabolism without affecting the cholesterol saturation index. Adult male prairie dogs underwent either sham laparotomy (eight prairie dogs) or ileal resection (16 prairie dogs). All animals were fed a trace cholesterol (nonlithogenic) diet before and for 4 weeks after operation. Pigment gallstones were present in 44% of the ileal-resected animals and in none of the sham animals (p less than 0.05). Calcium bilirubinate crystals were present in 94% of the ileal-resected animals and in none of the sham animals (p less than 0.01). Gallbladder bile calcium (25.6 +/- 2.4 versus 17.2 +/- 1.1 mg/dl; p less than 0.05) and total bilirubin (29.3 +/- 4.0 versus 9.4 +/- 1.8 mg/dl; p less than 0.01) concentrations were significantly greater in ileal-resected animals. The cholesterol saturation index of gallbladder bile, however, was no different in ileal-resected (0.53 +/- 0.04) and in sham-operated animals (0.50 +/- 0.04). Although initial studies suggested that the cholesterol saturation index of hepatic bile was increased after ileal resection, a second set of experiments demonstrated that this phenomenon resulted from washout of bile salts that were already in extremely low concentrations in hepatic bile. We conclude that alterations in bilirubin, but not cholesterol, metabolism result in pigment gallstone formation after ileal resection.
Novel tunable semiconductor lasers using continuously chirped distributed feedback gratings with ultrahigh spatial precision (1994)

We present experimental and theoretical results obtained from a new type of tunable two- and three-section semiconductor distributed feedback (DFB) laser using tailored chirped DFB gratings. The chirped gratings are defined by bent waveguides on homogeneous grating fields with ultrahigh spatial precision using bent waveguides. Arbitrary and continuous chirping functions can be obtained by appropriate mathematical bending functions. Our method is applied for tunable lasers with optimized bending shapes revealing a considerably enlarged wavelength tuning range of 5.5 nm without wavelength gaps.
Purification and Characterization of a New Lipase from<i>Fusarium</i>sp. YM-30 (1995)

The extracellular lipase from Fusarium sp. YM-30 was purified by a procedure involving ultrafiltration, ammonium sulfate precipitation, and DEAE-Toyopearl 650M, CM-Toyopearl 650M, and Butyl-Toyopearl 650M column chromatographies. The purified lipase was homogeneous with 12kDa of molecular mass by SDS-PAGE, and had high specificities for mono- and diacylglycerols, but low toward triacylglycerols. The enzyme had maximum activity at pH 7.0 to 8.0 and 37 degrees C, and hydrolyzed digalactosyl diglyceride too.
Identifying document topics using the Wikipedia category network (2009)

In the last few years the size and coverage of Wikipedia, a community edited, freely available on-line encyclopedia has reached the point where it can be effectively used to identify topics discussed in a document, similarly to an ontology or taxonom
Analysis and synthesis of facial image sequences in model-based image coding (1994)

This paper proposes new methods for analyzing image sequences and updating textures of the three-dimensional (3-D) facial model. It also describes a method for synthesizing various facial expressions. These three methods are the key technologies for the model-based image coding system. The input image analysis technique directly and robustly estimates the 3-D head motions and the facial expressions without any two-dimensional (2-D) entity correspondences. This technique resolves the 2-D correspondence mismatch errors and provides quality reproduction of the original images by fully incorporating the synthesis rules. To verify the analysis algorithm, the paper performs quantitative and subjective evaluations. It presents two methods for updating the texture of the facial model to improve the quality of the synthesized images. The first method focuses on the facial parts with large change of brightness according to the various facial expressions for reducing the transmission bit rates. The second method focuses on all changes of brightness caused by the 3-D head motions as well as the facial expressions. The transmission bit rates are estimated according to the update methods. For synthesizing the output images, it describes rules that simulate the facial muscular actions because the muscles cause the facial expressions. These rules more easily synthesize the high-quality facial images that represent the various facial expressions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Selective N-alkylation of amines using nitriles under hydrogenation conditions: facile synthesis of secondary and tertiary amines (2011)

Nitriles were found to be highly effective alkylating reagents for the selective N-alkylation of amines under catalytic hydrogenation conditions. For the aromatic primary amines, the corresponding secondary amines were selectively obtained under Pd/C-catalyzed hydrogenation conditions. Although the use of electron poor aromatic amines or bulky nitriles showed a lower reactivity toward the reductive alkylation, the addition of NH(4)OAc enhanced the reactivity to give secondary aromatic amines in good to excellent yields. Under the same reaction conditions, aromatic nitro compounds instead of the aromatic primary amines could be directly transformed into secondary amines via a domino reaction involving the one-pot hydrogenation of the nitro group and the reductive alkylation of the amines. While aliphatic amines were effectively converted to the corresponding tertiary amines under Pd/C-catalyzed conditions, Rh/C was a highly effective catalyst for the N-monoalkylation of aliphatic primary amines without over-alkylation to the tertiary amines. Furthermore, the combination of the Rh/C-catalyzed N-monoalkylation of the aliphatic primary amines and additional Pd/C-catalyzed alkylation of the resulting secondary aliphatic amines could selectively prepare aliphatic tertiary amines possessing three different alkyl groups. According to the mechanistic studies, it seems reasonable to conclude that nitriles were reduced to aldimines before the nucleophilic attack of the amine during the first step of the reaction.
The Cuban Crisis and Disarmament (1963)

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Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1 (2015)

Poly(ADP-ribose)polymerase 1 (PARP-1) is a key eukaryotic stress sensor that responds in seconds to DNA single-strand breaks (SSBs), the most frequent genomic damage. A burst of poly(ADP-ribose) synthesis initiates DNA damage response, whereas PARP-1 inhibition kills BRCA-deficient tumor cells selectively, providing the first anti-cancer therapy based on synthetic lethality. However, the mechanism underlying PARP-1's function remained obscure; inherent dynamics of SSBs and PARP-1's multi-domain architecture hindered structural studies. Here we reveal the structural basis of SSB detection and how multi-domain folding underlies the allosteric switch that determines PARP-1's signaling response. Two flexibly linked N-terminal zinc fingers recognize the extreme deformability of SSBs and drive co-operative, stepwise self-assembly of remaining PARP-1 domains to control the activity of the C-terminal catalytic domain. Automodification in cis explains the subsequent release of monomeric PARP-1 from DNA, allowing repair and replication to proceed. Our results provide a molecular framework for understanding PARP inhibitor action and, more generally, allosteric control of dynamic, multi-domain proteins.
Modern robust statistical methods: An easy way to maximize the accuracy and power of your research. (2008)

Classic parametric statistical significance tests, such as analysis of variance and least squares regression, are widely used by researchers in many disciplines, including psychology. For classic parametric tests to produce accurate results, the assumptions underlying them (e.g., normality and homoscedasticity) must be satisfied. These assumptions are rarely met when analyzing real data. The use of classic parametric methods with violated assumptions can result in the inaccurate computation of p values, effect sizes, and confidence intervals. This may lead to substantive errors in the interpretation of data. Many modern robust statistical methods alleviate the problems inherent in using parametric methods with violated assumptions, yet modern methods are rarely used by researchers. The authors examine why this is the case, arguing that most researchers are unaware of the serious limitations of classic methods and are unfamiliar with modern alternatives. A range of modern robust and rank-based significance tests suitable for analyzing a wide range of designs is introduced. Practical advice on conducting modern analyses using software such as SPSS, SAS, and R is provided. The authors conclude by discussing robust effect size indices.
Network formation in colloid–liquid crystal mixtures studied by confocal microscopy (2004)

We studied the formation of particle networks in colloid + liquid crystal mixtures cooled below the isotropic–nematic transition temperature by time-resolved laser scanning confocal microscopy. Our observations confirm a recent suggestion that alkane impurities play a crucial role in slowing down the speed of the isotropic–nematic interface. This enables the growing nematic droplets to 'push' particles into increasingly concentrated regions, ultimately resulting in a cellular network solid. We also found that faster cooling rates resulted in increasingly hierarchical cellular structures.
Wearable sensors for human health monitoring (2006)

Wearable sensors for continuous monitoring of vital signs for extended periods of weeks or months are expected to revolutionize healthcare services in the home and workplace as well as in hospitals and nursing homes. This invited paper describes recent research progress in wearable health monitoring technology and its clinical applications, with emphasis on blood pressure and circulatory monitoring. First, a finger ring-type wearable blood pressure sensor based on photo plethysmogram is presented. Technical issues, including motion artifact reduction, power saving, and wearability enhancement, will be addressed. Second, sensor fusion and sensor networking for integrating multiple sensors with diverse modalities will be discussed for comprehensive monitoring and diagnosis of health status. Unlike traditional snap-shot measurements, continuous monitoring with wearable sensors opens up the possibility to treat the physiological system as a dynamical process. This allows us to apply powerful system dynamics and control methodologies, such as adaptive filtering, single- and multi-channel system identification, active noise cancellation, and adaptive control, to the monitoring and treatment of highly complex physiological systems. A few clinical trials illustrate the potentials of the wearable sensor technology for future heath care services.
Services for the Multiply Severely Handicapped in Japan (1986)

There has been great social and administrative progress in services for the multiply severely handicapped in Japan. The present state of the handicapped in terms of their main diseases(ethiological classification), and their activities in daily life(ADL)is described. This description is based on the data on outpatients accumulated by the National Welfare Association of Severely Handicapped children in their research on 56 facilities in Japan in 1985. An example of medical and educational rehabilitation conducted at one facility is also described.
Effect of strain and surface composition on Young's modulus of optical fibers (1988)

In recent years the required in-service stress for optical fibers has risen dramatically. In the case where fibers are loaded to high stress levels (>200 kpsi), in bending, for example, it is generally assumed that material properties such as the Young’s modulus remain invariant with strain.
Iron-mediated Aggregation and a Localized Structural Change Characterize Ferritin from a Mutant Light Chain Polypeptide That Causes Neurodegeneration (2008)

Nucleotide insertions in the ferritin light chain (FTL) polypeptide gene cause hereditary ferritinopathy, a neurodegenerative disease characterized by abnormal accumulation of ferritin and iron in the central nervous system. Here we describe for the first time the protein structure and iron storage function of the FTL mutant p.Phe167SerfsX26 (MT-FTL), which has a C terminus altered in sequence and extended in length. MT-FTL polypeptides assembled spontaneously into soluble, spherical 24-mers that were ultrastructurally indistinguishable from those of the wild type. Far-UV CD showed a decrease in alpha-helical content, and 8-anilino-1-naphthalenesulfonate fluorescence revealed the appearance of hydrophobic binding sites. Near-UV CD and proteolysis studies suggested little or no structural alteration outside of the C-terminal region. In contrast to wild type, MT-FTL homopolymers precipitated at much lower iron loading, had a diminished capacity to incorporate iron, and were less thermostable. However, precipitation was significantly reversed by addition of iron chelators both in vitro and in vivo. Our results reveal substantial protein conformational changes localized at the 4-fold pore of MT-FTL homopolymers and imply that the C terminus of the MT-FTL polypeptide plays an important role in ferritin solubility, stability, and iron management. We propose that the protrusion of some portion of the C terminus above the spherical shell allows it to cross-link with other mutant polypeptides through iron bridging, leading to enhanced mutant precipitation by iron. Our data suggest that hereditary ferritinopathy pathogenesis is likely to result from a combination of reduction in iron storage function and enhanced toxicity associated with iron-induced ferritin aggregates.
H-ras-1 gene mutations in basal cell carcinoma: automated direct sequencing of clinical specimens. (1993)

Ras oncogenes are activated by point mutations occurring in codons 12, 13 or 61 and almost any base pair mutation occurring within the first two positions of any of these codons results in activation of the gene. Although ras point mutations have been reported to occur in several skin neoplasms including squamous carcinoma, keratoacanthoma and melanoma, their frequency of occurrence in basal cell carcinoma is not known. We examined basal cell carcinomas from 13 patients for activating mutations in the H-ras-1 gene by automated direct sequencing of polymerase chain reaction assay amplified targets. We amplified sequences in exon 1 that flanked codons 12 and 13 and amplified sequences in exon 2 that flanked codon 61. The PCR products were centrifuged and directly sequenced using antisense primers in an automated sequencer using fluorescent dideoxyterminators. One tumor was found to show an activating G to A transversion in codon 13 which code for aspartic acid instead of glycine. Although H-ras mutations may be found in some skin tumors, they are not frequent in basal cell carcinomas. From this study we believe that direct sequencing of clinical material is of value and has advantages over other techniques. Additional studies need to be undertaken to understand the true clinical significance of ras mutations in basal cell carcinomas when they occur.
Hydrophobic surfaces of tubulin probed by time-resolved and steady-state fluorescence of nile red. (1990)

Binding of Nile Red to tubulin enhances and blue-shifts fluorescence emission to about 623 nm with a "shoulder" around 665 nm. Binding is reversible and saturable with an apparent Kd of approximately 0.6 microM. Nile Red does not alter tubulin polymerization, and polymerization in 2-(N-morpholino)ethanesulfonic acid (Mes) buffer does not alter the spectrum of the Nile Red-tubulin complex. In contrast, polymerization in glutamate buffer results in a red shift, reduction of intensity, and a decrease in lifetime, suggesting an increase in "polarity" of the binding environment. Lifetimes of 4.5 and 0.6 ns fluorescence in Mes buffer are associated with the 623-nm peak and the 665-nm shoulder, respectively. Indirect excitation spectra for these components are distinct and the 4.5-ns component exhibits tryptophan to Nile Red energy transfer. Acrylamide quenching yields linear Stern-Volmer plots with unchanged lifetimes, indicating static quenching. Apparent quenching constants are wavelength-dependent; global analysis reveals a quenchable component corresponding to the 4.5 ns component and an "unquenchable" component superposing the 0.6-ns spectrum. Analysis of anisotropy decay required an "associative" model which yielded rotational correlation times of greater than 50 ns for the 4.5-ns lifetime and 0.3 ns for the 0.6-ns lifetime. Dilution of tubulin in Mes results in an apparent red shift of emission without lifetime changes, due only to loss of the 623-nm component. These data are reconciled in terms of a model with two binding sites on the tubulin dimer. The more "nonpolar" site is located in a region of subunit-subunit contact which accounts for the fluorescence changes upon dilution; this permits estimation of a subunit dissociation constant of 1 microM.
XIV. Researches on the refraction, dispersion, and sensitiveness of liquids (1863)

Abstract In a previous paper “On the Influence of Temperature on the Refraction of Light,” we started some inquiries which have been since pursued, and we now lay before the Royal Society some of the later results. The same apparatus has been employed, with a hollow prism of 61° 0' angle, and the method of observation has been essentially the same. But experience has led to some modifications, the most important of which is this: instead of attempting to take the angular measurements at certain foredetermined temperatures, as 10° C., 20° C., they were taken first at the temperature of the room, whatever that might be, and then at such other temperatures as seemed to offer the most trustworthy results. This involved more calculation, but it still saved time, and secured greater accuracy. The plan of measuring to 10" was abandoned as a useless nicety; but, as a rule, two or more observations of each fixed line at each temperature were taken, and if they differed slightly the mean was adopted, but if the discrepancy amounted to 2' or 3' the observation was repeated. The average of these observations of the lines A, D, and H at different temperatures gave the refractive indices which are placed together in the Table that constitutes Appendix I., and they afford the data for nearly all the comparisons about to be instituted. Appendix II. contains the mean determinations made of the refractive indices of some of these liquids for a larger number of the lines at the temperature of the room. To it have been added some observations on other liquids, and deter­minations published in our former papers, so as to render it as complete as possible for any who may desire to investigate the irrationality of the spectrum, or the truth of the formulae of Cauchy.
One-sided switching networks composed of partial access switching blocks (1988)

A new structure of one-sided digital switching networks composed of triangular switches is proposed. The structure is based on partial access switching blocks. The proposed networks contain fewer elements than those currently known.
Dealing with other parties (1992)

You are upstairs in your study at home. Your spouse or partner is in the kitchen below. You receive a 'phone call from work: you have to cancel the holiday which the two of you have been looking forward to all year because you are needed at work.
Time multiplexing super resolution using a Barker-based array (2015)

We propose the use of a new encoding mask in order to improve the performance of the conventional time multiplexing super resolution method. The resolution improvement is obtained using a 2D Barker-based array that is placed upon the object and shifted laterally. The Barker-based array is a 2D generalization of the standard 1D Barker code. The Barker-based array has stable autocorrelation sidelobes, making it ideal for the encoding process. A sequence of low resolution images are captured at different positions of the array, and are decoded properly using the same array. After removing the low resolution image from the resulting reconstruction, a high resolution image is established. The proposed method is presented analytically, demonstrated via numerical simulation, and validated by laboratory experiment.