gebhart/patrepeval huggingface dataset:
A Role for Myosin VI in the Localization of Axonal Proteins (2011)

In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites. Despite their central role in shaping neuronal form and function, surprisingly little is known about the molecular processes that mediate polarized targeting of neuronal proteins. Recently, the plus-end-directed motor Myosin Va was shown to play a critical role in targeting of transmembrane proteins to dendrites; however, the role of myosin motors in axonal targeting is unknown. Here we show that Myosin VI, a minus-end-directed motor, plays a vital role in the enrichment of proteins on the surface of axons. Engineering non-neuronal proteins to interact with Myosin VI causes them to become highly concentrated at the axonal surface in dissociated rat cortical neurons. Furthermore, disruption of either Myosin VI function or expression leads to aberrant dendritic localization of axonal proteins. Myosin VI mediates the enrichment of proteins on the axonal surface at least in part by stimulating dendrite-specific endocytosis, a mechanism that has been shown to underlie the localization of many axonal proteins. In addition, a version of Channelrhodopsin 2 that was engineered to bind to Myosin VI is concentrated at the surface of the axon of cortical neurons in mice in vivo, suggesting that it could be a useful tool for probing circuit structure and function. Together, our results indicate that myosins help shape the polarized distributions of both axonal and dendritic proteins.
Sequence matching of images (2002)

We propose an inter-sequence matching method for exact and similarity matching of image sequences. Our method transforms the image sequence matching problem into matching sequences of real numbers. The method does not require sequences to be of the same length. It uses a modified version of the longest common sequence (LCS) method for actually matching two sequences. We also propose a feature-based indexing mechanism to filter out those sequences which are matching candidates with a given query sequence from a large data set. Like all other feature-based indexing methods, our method maps each sequence into a point in K dimensional space, where K is the number of extracted features for the sequence. It operates in two phases, hypothesis and verification. Lengths and moments (mean and variance) of sequences are used as features. Experimental results indicate that the features and proposed method for query processing do well as a filter.
Fractionated radioimmunotherapy with <sup>90</sup> Y‐clivatuzumab tetraxetan and low‐dose gemcitabine is active in advanced pancreatic cancer (2012)

Fractionated radioimmunotherapy with (90) Y-hPAM4 and low-dose gemcitabine demonstrated promising therapeutic activity and manageable myelosuppression in patients with advanced pancreatic ductal carcinoma.
Highly oriented (Pb,La)(Zr,Ti)O/sub 3/ thin films on amorphous substrates (2003)

PLZT (lead lanthanum zirconate titanate) thin films have been deposited on various substrates, particularly on amorphous SiO/sub 2/, and on Si or GaAs with a buffer layer such as SiO/sub 2/. Regardless of whether the substrate is single crystal or not, many films are highly oriented with one of the [100], [110], or [111] directions normal to the substrate surfaces. Depending on the PLZT composition, substrate material, and deposition conditions, there are ten different film categories. Among these films the most interesting ones are the highly oriented films deposited on amorphous SiO/sub 2/ substrate because of the possibility of monolithic integration of integrated-optical thin film devices on Si and GaAs with a nonlattice matched buffer layer of SiO/sub 2/, the best optical transparent material for waveguiding and integrated optics. The crystal structure, grain size, morphology, composition, and symmetry of the thin film on SiO/sub 2/ have been studied.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Drainage of pelvic abscesses through the greater sciatic foramen. (1986)

A computed tomographic (CT) guided transgluteal approach through the greater sciatic foramen was used to drain pelvic abscesses and fluid collections in 21 patients. Ideal catheter placement should traverse the lower portion of the greater sciatic foramen at the level of the sacrospinous ligament. This avoids the vascular and neural elements that are located slightly cephalad at the level of the piriformis muscle. Percutaneous drainage through this approach was successful in avoiding surgery in 17 patients (81%). Pain was the most common complication and was generally associated with a more cephalad approach, transgressing the piriformis and the sacral plexus. CT-guided percutaneous drainage of pelvic abscesses through the greater sciatic foramen should be used when the more standard transperitoneal approach is not possible.
Green tea polyphenols inhibit photocarcinogenesis in mice through induction of IL-12, and IL-12-mediated immune responses in skin tumors (2005)

4303 Chronic exposure of solar ultraviolet (UV) radiation is the major etiologic agent for over one million new cases of non-melanoma skin cancers in the United States each year. These cutaneous malignancies thus have a tremendous impact on public health and healthcare expenditures. The use of dietary botanical supplements has received considerable interest to protect human skin from adverse biological effects of UV radiation since the protective clothing and use of sunscreens are not adequate to protect the skin. The use of green tea polyphenols (GTP) is one of them, and has been shown to prevent UV carcinogenesis in animal models but their mechanism of photoprotection is not clearly understood specifically when administered in drinking water (d.w.). To determine the skin cancer chemopreventive mechanism of GTP in in vivo mouse model, the SKH-1 hairless mice were given GTP (0.2%, w/v) in d.w. throughout the photocarcinogenesis protocol. Oral administration of GTP resulted in prevention of UV carcinogenesis in mice in terms of tumor incidence, tumor multiplicity and tumor growth. Since UV-induced suppression of immune responses is considered as a risk factor for skin cancer, we examined the effect of GTP on various immunological parameters in tumors using immunostaining and Western blotting. Our data revealed that administration of GTP resulted in inhibition of immunosuppressive cytokine, interleukin (IL)-10, whereas increased the production of IL-12 in UV-induced tumors compared with non-GTP treated animals. The inhibition of IL-10 and induction of IL-12 was associated with the inhibition of PGE2 production in tumors. Since, IL-12 has been shown to have anti-tumor immune responses, we extended our study to examine its effect on various immunological and angiogenic biomarkers. We found that GTP down-regulated the expressions of vascular endothelial cell antigens, such as CD31 and VEGF, which are essential for tumor growth and angiogenesis. GTP inhibited the expression of PCNA in tumor cells. In further studies, GTP treatment markedly down-regulated UV-induced expression of matrix metalloproteinase (MMP)-2 and MMP-9 which play a crucial role in tumor growth, invasion and metastasis, however increased the expression of its inhibitor TIMP1. Additionally, a higher number of cytotoxic T lymphocytes (CD8+ T cells) were detected by immunofluorescence staining in GTP+UV treated tumors which indicated that GTP enhances the development of CD8+ T cells in tumor microenvironment. CD8+ T cells are tumoricidal and thus may result in the inhibition of tumor growth. Since anti-tumor immune response or activity of IL-12 has been associated with above mentioned biomarkers, our data suggest that skin cancer chemopreventive effect of GTP may be mediated through the induction of IL-12 in tumors.
Pet Ownership and Attachment as Supportive Factors in the Health of the Elderly (1989)

In order to examine pet ownership and pet attachment as factors supporting the health of the elderly, a national probability sample of Americans 65 years of age and older was drawn. Participants answered telephone survey questions regarding pet ownership, life stress, social support, depression, and recent illness. In multiple regression analyses, pet ownership failed to predict depression and illness behavior, while pet attachment significantly predicted depression but not illness experience. In a group with particularly great distress (the bereaved), pet ownership and strong attachment were significantly associated with less depression only when the number of available confidants was minimal.
Transcatheter closure of coronary artery fistula using Guglielmi detachable coil (2012)

BackgroundCoronary 动脉管(CAF ) 是一个稀罕异例。Transcatheter CAF 闭合用各种各样的材料被介绍了，但是仅仅很少数据在 Guglielmi 可拆卸的卷(GDC ) 上是可得到的。为 transcatheter CAF 闭合使用 GDC 的优点是更可控制的，因此安全得多什么时候与另外的卷相比。这份报告关于我们在用在我们的 hospital.Methods & 的 fibered GDC 的 CAF 的 transcatheter 闭合的经验；ResultsFrom 2002 到 2007，有有 CAF 的 10 个病人(年龄范围：28 ～ 56 27 岁的孩子， 7 男性) 经历了 transcatheter CAF 闭合。有发源从的 19 CAF 的一个总数恰好冠(n = 5 ) ，左降声调符号(n = 3 ) ，左前面的下降动脉(n = 10 ) 并且左主要箱子(n = 1 ) 。为每管的卷推广的中部的数字是 3 (范围：1 ～ 6 ) 。肺的动脉是 CAF 的远侧的通讯的最普通的地点(n = 14 ) ，由正确中庭列在后面(n = 3 ) ，左中庭(n = 1 ) 并且左室(n = 1 ) 。在 GDC 推广以后的立即的冠的 angiography 没在 12 揭示剩余分流(63.2%) CAF，在 5 的流动(26.3%) 的重要减小，当(10.5%) 2 不能由于小尺寸被关上时。九(90%) 病人们在 3 ～ 8 个月以内经历了重复 angiography。在 12 CAF 之中，那被堵塞立即推广以后，有有不足道的剩余流动的 2 CAF。在有显著地减少的流动的 6 CAF 之中立即推广以后， 2 在后续 angiography 完全被堵塞。总共， 12 (70.5%) CAF 完全被堵塞并且 5 (29.5%) CAF 仍然有不足道的剩余流动，它不需要任何另外的卷推广。在一个平均数期间列在后面在上面 4.3 ±；0.7 年，所有病人仍然是症状和复杂并发症 free.ConclusionsThe fibered GDC 是为 CAF 的经皮的闭合的一个安全、有效的方法。
NMOS and PMOS transistors fabricated in strained silicon/relaxed silicon-germanium structures (1992)

N- and P-MOSFETs have been fabricated in various epitaxial layer structures containing relaxed Si/sub 1-x/Ge/sub x/, and strained Si active regions. Theoretical calculations predict that the strain-splitting of the conduction bands should produce a higher bulk electron mobility in strained Si. Enhanced electron mobilities have recently been observed in n-type modulation-doped structures employing strained Si. In this work we demonstrate NMOS transistors with peak room temperature electron mobilities which are a factor of 2.2 larger than those measured in devices fabricated in CZ Si substrates. By comparing the behavior of buried- and surface-channel structures, we have observed mobility enhancements associated with both the separation of the electrons from the semiconductor/oxide interface, and the strain-induced band splitting. The room temperature performance of PMOS devices fabricated in such structures is not significantly different from that of the Si control devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Simulations of symptomatic treatments for Alzheimer's disease: computational analysis of pathology and mechanisms of drug action (2012)

This quantitative systems pharmacology approach is shown to be complementary to traditional animal models, with the potential to assess potential off-target effects, the consequences of pharmacologically active human metabolites, the effect of comedications, and the impact of a small number of well described genotypes.
Transformation of Chromosomal and Plasmid Characters in <i>Staphylococcus aureus</i> (1972)

Plasmid and probably also chromosomal characters have been genetically transformed in Staphylococcus aureus. Recipient cells show competence throughout the exponential growth phase with a maximum at early times.
Analysis of Coxiella burnetii isolates in cell culture and the expression of parasite-specific antigens on the host membrane surface. (1991)

Coxiella burnetii isolates may be classified into several groups based on plasmid character. These groups may also be correlated with disease syndrome--chronic or short-term acute. L929 mouse fibroblast cells were exposed, independently, to two members of the three major C. burnetii groups, and their growth/morphological characteristics analysed by light and electron microscopy, including High Voltage Electron Microscopy. The fates of the isolates were followed. Two acute isolates [Nine Mile (RSA 493) and Henzerling (RSA 331), QpH1-type plasmids] and two chronic isolates (S Q217 and L Q216, plasmidless) readily infected L929 cells in static culture. Priscilla (Q177) and F (Q228) isolates (QpRS-type plasmid, and implicated in causing chronic Q fever) took longer to infect cells, and, unlike the members of the other two groups, gradually disappeared when shifted to suspension culture. Cells infected with Q177 and Q228 exhibited a higher degree of vacuolation than cells infected with the other isolates. Parasite-specific antigens on the surfaces of the host cells were analysed by immunofluorescence/flow cytometry. The acute and plasmidless isolates caused the display of significantly more C. burnetii-specific antigen on the host cell membrane than the two QpRS plasmid-containing isolates. This host cell model system clearly reveals biological differences among the C. burnetii groups.
Protein and carbohydrate moieties of a preparation of β-lactamase II (1971)

1. A crystalline preparation of beta-lactamase II has been separated into two moieties by gel filtration on a column of Sephadex G-100. 2. The first moiety consisted mainly of carbohydrate and showed virtually no beta-lactamase activity. 3. The second moiety was a protein of molecular weight 22500, which was enzymically active. 4. The protein moiety, like the original protein-carbohydrate complex, required Zn(2+) for beta-lactamase activity. It did not differ significantly from the complex in its behaviour to a number of cephalosporin substrates, but was less stable to heat than the complex. 5. About 30% of the total beta-lactamase activity was lost when the protein-carbohydrate complex was separated into the two moieties. This activity was regained when the protein and carbohydrate moieties were mixed, but the mixture did not show the heat stability of the original complex.
A Multiplier Adjustment Method for the Generalized Assignment Problem (1986)

We describe a branch and bound algorithm for the generalized assignment problem in which bounds are obtained from a Lagrangian relaxation with the multipliers set by a heuristic adjustment method. The algorithm was tested on a large sample of small random problems and a number of large problems derived from a vehicle routing application. Computation times were reasonable in all cases and the branch and bound trees generated had nearly two orders of magnitude fewer nodes than for competing algorithms. Although comparison of running times on different machines is difficult, the multiplier adjustment method appears to be about one order of magnitude faster than the best previously existing algorithms for this problem.
Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skinfold model (1998)

Effect of increasing blood viscosity during extreme hemodilution on capillary perfusion and tissue oxygenation was investigated in the awake hamster skinfold model. Two isovolemic hemodilution steps were performed with 6% Dextran 70 [molecular weight (MW) = 70,000] until systemic hematocrit (Hct) was reduced by 65%. A third step reduced Hct by 75% and was performed with the same solution [low viscosity (LV)] or a high-molecular-weight 6% Dextran 500 solution [MW = 500, 000, high viscosity (HV)]. Final plasma viscosities were 1.4 and 2.2 cP (baseline of 1.2 cP). Hct was reduced to 11.2 +/- 1.1% from 46.2 +/- 1.5% for LV and to 11.9 +/- 0.7% from 47.3 +/- 2.1% for HV. HV produced a greater mean arterial blood pressure than LV. Functional capillary density (FCD) was substantially higher after HV (85 +/- 12%) vs. LV (38 +/- 30%) vs. baseline (100%). PO2 levels measured with Pd-porphyrin phosphorescence microscopy were not statistically changed from baseline until after the third hemodilution step. Wall shear rate (WSR) decreased in arterioles and venules after LV and only in arterioles after HV. Wall shear stress (WSR x plasma viscosity) was substantially higher after HV vs. LV. Increased mean arterial pressure and shear stress-dependent release of endothelium-derived relaxing factor are possible mechanisms that improved arteriolar and venular blood flow and FCD after HV vs. LV exchange protocols.
Anti-inflammatory Renoprotective Effect of Clopidogrel and Irbesartan in Chronic Renal Injury (2007)

Recent evidence suggests that platelet activation and angiotensin II may each contribute to glomerular inflammation and fibrosis. Clopidogrel inhibits platelet activation and may also reduce inflammation. This study investigated the anti-inflammatory and renoprotective effects of clopidogrel and irbesartan in the five-sixths nephrectomy rat model of chronic kidney disease. After 8 wk of treatment, 24-h proteinuria, serum creatinine, and histologic scores of glomerular sclerosis and tubulointerstitial damage were significantly lower in treated compared with untreated rats. Clopidogrel/irbesartan combination therapy had greater effects than either drug alone. Rats that underwent five-sixths nephrectomy had higher markers of platelet activation (plasma GMP-140 and renal cortical fibrin deposition) than sham-operated rats, and clopidogrel attenuated these effects. Clopidogrel and irbesartan similarly reduced the accumulation of ED-1-expressing macrophages in the cortical glomeruli and the interstitium. Combination therapy almost completely abolished macrophage infiltration and attenuated the expression of monocyte chemoattractant protein-1, intercellular adhesion molecule-1, TGF-beta(1), and connective tissue growth factor. In conclusion, combination treatment with clopidogrel and irbesartan, more so than either alone, decreases early renal injury induced by five-sixths nephrectomy by inhibiting renal inflammation.
Nonlinear analysis methods for the simulation of digital wireless communication systems (1996)

Adoption of digital modulation for many wireless communication systems has resulted in significant performance improvements over systems based on analog modulation. Concomitant with this have been changes in methods of characterizing and simulating system performance, particularly with respect to amplifier linearity. Digitally modulated signals are best represented by a power spectral density. In contrast, analog-modulated signals are adequately represented by discrete spectra. Consequently, many of the common discrete spectra nonlinear microwave analysis techniques are ill-suited to simulating systems characterized by signals with power spectral density representations. This study examines some of the common types of signals used in digital wireless communication systems, and looks at their representation and characterization. The applicability of various nonlinear analysis methods to microwave power amplifier simulation in the context of digital modulation is explored. © 1996 John Wiley & Sons, Inc.
Molecular Basis for the Recognition of Herpes Simplex Virus Type 1 Infection by Human Natural Killer Cells (2018)

Primary infection with Herpes simplex virus type 1 (HSV1) is subclinical or only mildly symptomatic in normal individuals, yet the reason for the body's effective immune defense against this pathogen in the absence of antigen-specific immunity has not been well understood. It is clear that human natural killer (NK) cells recognize and kill HSV1-infected cells, and those individuals who either lack or have functionally impaired NK cells can suffer severe, recurrent, and sometimes fatal HSV1 infection. In this article, we review what is known about the recognition of HSV1 by NK cells, and describe a novel mechanism of innate immune surveillance against certain viral pathogens by NK cells called Fc-bridged cell-mediated cytotoxicity.
Discussion on Firewall Technology (2009)

This article introduces the concept and principle of the firewall technology,as well as its classification and comparision,also it points out the disadvantages of the traditional firewall and suggests a new type of embedded firewall system.The prospects for firewall are made.
Forecasters of a more cost-effective future. Interview by Joyce Gildea. (1987)

Dr. Linda H. Aiken is The Robert Wood Johnson Foundation Vice President who evaluates health-related programs funded by this large and influential organization. In this interview, the first of several with executives of foundations whose efforts often forecast effective approaches to health care and cost problems, Dr Aiken discusses The Robert Wood Johnson Foundation's funding interests.
Theory of Poole-Frenkel conduction in low-mobility semiconductors (1972)

Abstract A new expression is derived for the current produced by a high electric field in a low-mobility semiconductor, taking into account the mechanism of Poole-Frenkel emission from a Coulombic trap, the mobility of the carrier after emission into the conduction band, and the zero-field statistical distribution of carriers between conduction band, donor states and compensating acceptor states. Differences between these and earlier formulae are examined, and arguments presented for the different regimes of applicability. Recent data on amorphous germanium are considered, using the various formulae, and it is concluded that high-field transport measurements alone are insufficient to define uniquely the parameters of such theories.
APOBEC3G upregulation by alpha interferon restricts human immunodeficiency virus type 1 infection in human peripheral plasmacytoid dendritic cells (2008)

APOBEC3G (A3G), a member of cytidine deaminase family, has potent anti-human immunodeficiency virus type 1 (HIV-1) activity. It has been demonstrated that alpha interferon (IFN-alpha) can significantly enhance the expression of A3G in human primary resting CD4(+) T-cells, macrophages and primary hepatocytes, subsequently decreasing their viral susceptibility. Plasmacytoid dendritic cells (pDCs) are key effectors in innate host immunity, mediating adaptive immune responses and stimulating IFN-alpha production in reaction to various stimuli. In this report, we demonstrate that IFN-alpha, either exogenously added to- or endogenously secreted by pDCs, can enhance the expression of A3G and its family members such as A3A, A3C and A3F. We have also shown that IFN-alpha can inhibit HIV-1 expression in pDCs. This inhibitory effect could be countered by addition of an A3G-specific short interfering RNA, indicating that IFN-alpha-induced A3G plays a key role in mediating pDCs response to HIV-1. Given the central role played by pDCs in orchestrating the IFN-alpha/A3G intercellular network and intracellular signal pathway, our data indicate that pDCs themselves are also protected by an IFN-alpha/A3G-mediated innate immunity barrier from HIV-1 infection.
Enhanced detection of buried assets (2008)

This paper reports the design of a new resonator system to enhance the identification of buried underground assets. Results from theoretical calculation, simulation, laboratory measurement, and field test are presented and practical considerations are highlighted. The proposed system has the potential to benefit future civil engineering installations.