gebhart/patrepeval huggingface dataset:
11.5 W pulsed operation of antiguided laser diode array (1992)

A 40-stripe array of antiguided laser diodes is operated to a pulsed output power of 11.5 W. At the output power of 11.5 W, the full width at half maximum of the central lobe of the in-phase far field is 1°.
Cupreines and Cupreidines: An Emerging Class of Bifunctional Cinchona Organocatalysts (2006)

In the steadily expanding field of organocatalysis, cinchona alkaloids play a prominent role. Until the late 1990s, bifunctional catalysts based on this scaffold relied exclusively on the C9-hydroxy group as the hydrogen-bond donor. Recently, new cinchona catalysts have been developed that feature a phenolic OH group in the C6' position-a structural feature that allows a diverse set of reactions to be catalyzed in a highly stereoselective fashion. This Minireview describes the scope and modes of action of this new class of asymmetric bifunctional organocatalysts.
Growth and development of tomato seedlings in sphagnum peat, vermiculite, and processed rice hull substrates (2005)

Tomato (Lycopersicum esculentum ‘Early Girl’) seedling growth was evaluated in substrates containing varying proportions of ground rice hulls. Substrates were formulated containing 0, 30, 60, and 90% ground rice hulls with one-half of the treatments also treated with a surfactant. Seedling growth in two of the ground rice hull-containing substrates was generally similar to the two controls of 90% peat or 100% vermiculite. The germination percentages for all ground rice hull-containing substrates were similar to the two controls. Ground rice hulls are a viable alternative to peat and vermiculite seedling substrates.
Assessment of CFTR Function after Gene Transfer In Vitro and In Vivo (2008)

Cystic fibrosis (CF) a monogenic lethal disease and, therefore, ideally suited for the development of gene therapy. The first clinical trials were carried out shortly after cloning the CF gene in 1989. Since then, 25 trials have been carried out. Proof of principle for low-level airway gene transfer was established in most, but not all, trials. It is currently unclear whether current gene transfer efficiency will lead to improvements in clinically relevant endpoints such as inflammation or infection. In addition to addressing this important question, we and others are further improving airway gene transfer, by modifying existing and developing new gene transfer agents. Here, we describe pre-clinical methods related to assessing correction of the CF chloride transport defect.
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies (2017)

This study expands the view of CRC cell lines as accurate molecular models of primary carcinomas, and we present integrated multi-level molecular data of 34 widely used cell lines in easily accessible formats, providing a resource for preclinical studies in CRC.
RF/mmWave Front-End Module Switch in 22nm FDSOI Process (2018)

This paper highlights 22nm FDSOI technology application in RF and mmWave Front-End modules by demonstrating a 1-dB Insertion Loss SPST switch and a reduced substrate capacitance switch with an. excellent IIP3 of 43dBm at 28GHz. Reliability measurements show the switches can handle up to 23dBm of power at mmWave frequencies under mismatched conditions, an essential requirement for antenna switches. Also, a measured Ron* Coff of 98fs at 28GHz prove the viability of 22nm FDSOI in emerging 5G markets.
Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses. (2002)

The approaches generated in these studies provide a simple, safe, and effective method for prospectively acquiring and processing breast core needle biopsies for gene expression studies. Gene expression data from these studies can be used to build accurate predictive models that separate different molecular profiles. The data establish the use and effectiveness of these approaches for future prospective studies.
Embracing heterogeneity: parallel programming for changing hardware (2009)

Computer systems are undergoing significant change: to improve performance and efficiency, architects are exposing more microarchitectural details directly to programmers. Software that exploits specialized accelerators, such as GPUs, and specialized processor features, such as software-controlled memory, exposes limitations in existing compiler and OS infrastructure. In this paper we propose a pragmatic approach, motivated by our experience with Merge [3], for building applications that will tolerate changing hardware. Our approach allows programmers to leverage different processor-specific or domain-specific toolchains to create software modules specialized for different hardware configurations, and it provides language mechanisms to enable the automatic mapping of the application to these processor-specific modules. We show this approach can be used to manage computing resources in complex heterogeneous processors and to enable aggressive compiler optimizations. 1
Extended multi‐flip‐angle <i>B</i><sub>1</sub> mapping: A 3D mapping method for inhomogeneous <i>B</i><sub>1</sub> fields (2010)

Abstract Quantitative, three‐dimensional mapping of the B 1 field per unit current is necessary for comprehensive characterization of the performance of radiofrequency coils. A mapping method with high dynamic range is required, particularly for surface and array coils with inhomogeneous B 1 fields. For many applications, the main magnetic field cannot be assumed to be uniform across the sensitive volume of the RF coil. B 1 mapping methods relying on on‐resonance conditions thus yield erroneous results. We have, therefore, developed an extension of the multi‐flip‐angle approach (ExMFA) for B 1 mapping in inhomogeneous B 0 and B 1 fields with high dynamic range. Based on simulations and experimental data, ExMFA is compared to the commonly used double‐angle and the standard multi‐flip‐angle approaches with special focus on applications in inhomogeneous excitation fields. Comparative evaluation reveals the improved performance of the ExMFA approach. © 2010 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 37B: 203–214, 2010
Resonant diffraction of synchrotron radiation by a nuclear multilayer (1993)

We report the observation of nuclear resonant diffraction of synchrotron radiation by a synthetic multilayer. The nuclear period of the ${[}^{57}$Fe(22 \AA{})/Sc(11 \AA{})/Fe(22 \AA{})/Sc(11 \AA{})\ifmmode\times\else\texttimes\fi{}25 multilayer was chosen to be twice the electronic period to obtain a pure nuclear Bragg reflection. Strong enhancement of the radiative scattering channel provided a fast time response for the $^{57}\mathrm{Fe}$ resonant scattering at the Bragg peak, with a decay time of 4 ns. The nuclear multilayer will be useful as a narrow bandpass monochromator for synchrotron radiation.
Human Endogenous Retrovirus-K and TDP-43 Expression Bridges ALS and HIV Neuropathology (2017)

Despite the repetitive association of endogenous retroviruses in human disease, the mechanisms behind their pathological contributions remain to be resolved. Here we discuss how neuronal human endogenous retrovirus-K (HERV-K) expression in human immunodeficiency virus (HIV)-infected individuals is a distinct pathological aspect of HIV-associated neurological conditions, such as HIV encephalitis and HIV-associated neurocognitive disorders. Enhanced neuronal HERV-K levels were observed in the majority of HIV-infected individuals, and to a higher degree in brain tissue marked by HIV replication. Moreover, we highlight an important neuropathological overlap between amyotrophic lateral sclerosis and HIV encephalitis, that being the formation of neurotoxic TDP-43 deposits in neurons. Herein, we argue for enhanced transdisciplinary research in the field of ERV biology, using an example of how HERV-K expression has novel mechanistic and therapeutic implications for HIV neuropathology.
The treatment of gastroparesis in the age of the gastric pacemaker: a review. (2003)

Gastroparesis is a chronic disabling condition of impaired gastric motility that results in decreased quality of life. Currently available medical therapy consists of prokinetic medication combined with antiemetic therapy, dietary modifications, and nutritional supplementation. Many patients continue to have a suboptimal clinical response despite maximal use of these modalities. Instead of surgery, which involves irreversible stomach-modifying procedures, gastric electrical stimulation (GES) with a high-frequency/low-energy stimulus was approved by the US Food and Drug Administration (FDA) and can now be used in this setting. This approach has been shown to decrease symptom frequency and severity, reduce hospitalizations and medical costs, and improve quality of life. Occurrence of complications with this device are uncommon (< 5% of patients). Preliminary studies of new gastric stimulators that restore gastric contractility are promising, but additional investigation is needed. This article reviews the pathophysiology and epidemiology of gastroparesis and the role of conventional medical therapies, and discusses GES therapy with respect to its mechanisms of action, appropriate application, results and benefits, and future directions.
Momentum control for balance (2009)

We demonstrate a real-time simulation system capable of automatically balancing a standing character, while at the same time tracking a reference motion and responding to external perturbations. The system is general to non-human morphologies and results in natural balancing motions employing the entire body (for example, wind-milling). Our novel balance routine seeks to control the linear and angular momenta of the character. We demonstrate how momentum is related to the center of mass and center of pressure of the character and derive control rules to change these centers for balance. The desired momentum changes are reconciled with the objective of tracking the reference motion through an optimization routine which produces target joint accelerations. A hybrid inverse/forward dynamics algorithm determines joint torques based on these joint accelerations and the ground reaction forces. Finally, the joint torques are applied to the free-standing character simulation. We demonstrate results for following both motion capture and keyframe data as well as both human and non-human morphologies in presence of a variety of conditions and disturbances.
T-Cell Costimulatory Pathways in Allograft Rejection and Tolerance (2005)

A key factor driving the underlying pathyphysiology of "chronic rejection" in organ transplantation is a persistent T cell-mediated alloimmune response. Members of both the B7 family (including CD28 and CTLA4) and the tumor necrosis factor (TNF) family, in which the CD40-CD154 pathway is preeminent, play key roles in the T cell response following alloantigen presentation. "Positive" costimulatory molecules promote full T cell activation, whereas a subgroup of costimulatory molecules delivers "negative" costimulatory signals that function to downregulate alloimmune responses. Emerging experimental data point to key differences between the various positive and negative costimulatory molecules in terms of their temporal and spatial expression profiles, their effects of T and B cell subsets, and on their relative importance within the hierarchy of costimulatory signals delivered to the T cell. In this review, we address the role of costimulatory pathways in allograft rejection and tolerance. We will address in particular the potential of the novel costimulatory pathways as targets for tolerance induction in CD28-independent alloresponses, and we will review emerging data that suggests a key role for parenchymal expression of negative costimulatory molecules in the termination of pathogenic immune responses.
Patterns of Brain Activation in People at Risk for Alzheimer's Disease (2000)

Patterns of brain activation during tasks requiring memory differ depending on the genetic risk of Alzheimer's disease and may predict a subsequent decline in memory.
Variability of the location of the tibial tubercle affects the rotational alignment of the tibial component in kinematically aligned total knee arthroplasty (2012)

IV.
Keyless Jam Resistance (2007)

Traditionally, omnidirectional, radio frequency (RF) communication has been made resistant to jamming by the use of a secret key that is shared by the sender and receiver. There are no known methods for achieving jam resistance without that shared key. Unfortunately, wireless communication is now reaching a scale and a level of importance where such secret-key systems are becoming impractical. For example, the civilian side of the global positioning system (GPS) cannot use a shared secret, since that secret would have to be given to all 6.5 billion potential users, and so would no longer be secret. So civilian GPS cannot currently be protected from jamming. But the FAA has stated that the civilian airline industry will transition to using GPS for all navigational aids, even during landings. A terrorist with a simple jamming system could wreak havoc at a major airport. No existing system can solve this problem, and the problem itself has not even been widely discussed. The problem of keyless jam resistance is important. There is a great need for a system that can broadcast messages without any prior secret shared between the sender and receiver. We propose the first system for keyless jam resistance: the BBC algorithm. We describe the encoding, decoding, and broadcast algorithms. We then analyze it for expected resistance to jamming and error rates. We show that BBC can achieve the same level of jam resistance as traditional spread spectrum systems, at just under half the bit rate, and with no shared secret. Furthermore, a hybrid system can achieve the same average bit rate as traditional systems.
Compact microstrip-T coupled patch antenna for dual polarisation and active antenna applications (2002)

A novel way of feeding single-layer microstrip patch antennas using electromagnetically coupled microstrip-T junctions is proposed. The measured isolation and 10 dB bandwidth of an X-band dual polarised antenna are ∼32 dB and 2.1%, respectively, on an εr 3.0 substrate. Since both ports of the antenna are electromagnetically coupled, the proposed antenna eliminates the need for capacitors in the RF path for active antenna applications.
A New Adaptive Self-Tuning Fourier Coefficients Algorithm for Periodic Torque Ripple Minimization in Permanent Magnet Synchronous Motors (PMSM) (2013)

A New Adaptive Self-Tuning Fourier Coefficients Algorithm for Periodic Torque Ripple Minimization in Permanent Magnet Synchronous Motors (PMSM) Torque ripple occurs in Permanent Magnet Synchronous Motors (PMSMs) due to the non-sinusoidal flux density distribution around the air-gap and variable magnetic reluctance of the air-gap due to the stator slots distribution. These torque ripples change periodically with rotor position and are apparent as speed variations, which degrade the PMSM drive performance, particularly at low speeds, because of low inertial filtering. In this paper, a new self-tuning algorithm is developed for determining the Fourier Series Controller coefficients with the aim of reducing the torque ripple in a PMSM, thus allowing for a smoother operation. This algorithm adjusts the controller parameters based on the component's harmonic distortion in time domain of the compensation signal. Experimental evaluation is performed on a DSP-controlled PMSM evaluation platform. Test results obtained validate the effectiveness of the proposed self-tuning algorithm, with the Fourier series expansion scheme, in reducing the torque ripple.
Diagnosis of Multiple Scan Chain Timing Faults (2008)

A diagnosis technique is presented to locate multiple timing faults in scan chains. Jump simulation is a novel parallel simulation technique which quickly searches for the upper and the lower bounds of every individual fault. The proposed technique takes into account the interaction of multiple faults so the diagnosis results are deterministic, not probabilistic. This technique is very useful in the production test environment because it requires only regular automated test pattern generator patterns, not specialized diagnosis patterns. Experiments on ISCAS'89 benchmark circuits show that this technique can successfully pinpoint almost every single one of 16 hold-time faults in a scan chain of more than 800 scan cells. The proposed technique is still effective when failure data are limited or faults are clustered.
LITURGICA (1900)

Journal Article LITURGICA Get access F. E. B. F. E. B. Search for other works by this author on: Oxford Academic Google Scholar The Journal of Theological Studies, Volume os-I, Issue 4, July 1900, Pages 630–635, https://doi.org/10.1093/jts/os-I.4.630 Published: 01 July 1900
<i>In vivo</i> Biology and Toxicology of Fullerenes and Their Derivatives (2008)

Fullerenes represent a group of nanoparticles discovered in 1985. They are spherical molecules consisting entirely of carbon atoms (C(x)) to which side chains can be added, furnishing compounds with widely different properties. Fullerenes interact with biological systems, for example, by enzyme inhibition, causing phototoxic reactions, being scavengers of reactive oxygen species and free radicals, in addition to being able to initiate free radical reactions. Absorption, distribution and excretion strongly depend on the properties of the side chains. The pristine C(60) has a very long biological half-life, whereas the most water-soluble derivatives are eliminated from the exposed animals within weeks. A long biological half-life raises concern about bioaccumulation and long-term effects. In general, the acute oral, dermal and airway toxicity is low. However, few relevant experimental studies of repeated dose toxicity, reproductive toxicity and carcinogenic effect are available. The data suggest that direct DNA damaging effects are low, but formation of reactive oxygen species may cause inflammation and genetic damage. Apparently, it is dose-dependent whether a beneficial or an adverse effect occurs.
Decreased in vivo survival of hydrogen peroxide-damaged baboon red blood cells (1990)

Abstract In this study we attempt to establish the consequence of in vitro hydrogen peroxide (H2O2)-induced membrane damage as manifested by spectrin-hemoglobin (Sp-Hb) complex formation and decreased red blood cell (RBC) deformability to in vivo RBC survival in baboons. After exposure to 135 to 581 mumols/L H2O2 and reduction with dithiothreitol (DTE), baboon RBCs were infused into the animal, and the fraction of cells remaining in circulation after 24 hours and the lifespan of surviving cells were quantitated. In a dose-dependent fashion, a positive correlation was observed between in vitro membrane alterations and the 24-hour in vivo survival. While 12% of the control cells were removed from circulation in 24 hours, 23% were removed after treatment with 339 mumols/L H2O2, and 36% following exposure to 581 mumols/L H2O2. Pretreatment with carbon monoxide before exposure with H2O2 increased the survival of oxidized RBCs. RBCs not removed from circulation in the first 24 hours had a normal lifespan. Moreover, by selectively isolating biotin-labeled, peroxide-treated cells that survived the first 24-hour posttransfusion period, a significant decrease in Sp-Hb crosslinking was observed in these cells. These results suggest that a subpopulation of cells sensitive to oxidation were removed during the first 24 hours. To identify this population, the survival of density-fractionated RBCs exposed to oxidant stress was quantitated. No differences in either the 24-hour survival or RBC life span were observed between untreated low-density (MCHC less than or equal to 32g/dL) and high-density cells (MCHC greater than or equal to 37g/dL). However, striking differences were noted after treatment with 339 mumols/L H2O2, with the 24-hour survival of high-density cells showing a marked decrease compared with low-density cells. These data support our hypothesis that during peroxidative membrane damage, Hb oxidation initiates a sequence of events resulting in skeletal changes that lead to membrane alterations and, eventually, in vivo destruction, and that the dense, dehydrated cells are more susceptible to oxidant damage.
Development of Antifouling Hyperbranched Polyglycerol Layers on Hydroxyl Poly-<i>p</i>-xylylene Coatings (2017)

Antifouling surfaces that are resistant to protein adsorption and cell adhesion are desirable for many biomedical devices, such as diagnostic devices, biosensors, and implants. In this study, we developed an antifouling hyperbranched polyglycerol (hPG) surface on hydroxyl poly-p-xylylene (PPX-OH). PPX-OH was deposited via chemical vapor deposition (CVD), and an hPG film was then developed via the ring-opening reaction of glycidol. The hPG film greatly reduced the adhesion of L929 cells and platelets as well as protein adsorption. The addition of alkenyl groups in the hPG layer allows the conjugation of biomolecules, such as peptides and biotin, and elicits specific biological interactions. Since the CVD deposition of PPX-OH could be applied to most types of materials, our approach makes it possible to decorate an antifouling hPG film on most types of materials. Our method could be applied to biosensors, diagnostics, and biomedical devices in the future.
Interactions between epididymal secretions and spermatozoa. (1998)

The interactions between spermatozoa and epididymal secretions are reviewed with respect to the nature of the interactions, the maturity of the spermatozoa and the environment in which spermatozoa mature. The estimated ionic strength of epididymal fluid is low enough for all peripheral proteins to be in close contact with the membrane. Two sorts of interactions are evident, those dependent on the state of the maturity of the spermatozoa (for example peripheral proteins and some integral proteins) and those independent of it (many integral proteins). For the former, a change in the sperm membrane charge must occur to permit recognition of peripheral proteins and the insertion of secreted charged integral membrane proteins may precede the interaction with more distally secreted products. For integral proteins, partition into the membrane may depend on the composition of the plasma membrane. Changes in the sterol content of particular domains have been documented and an array of lipid-binding proteins secreted by the epididymis may mediate these changes. The dependence of the transfer of lipid-anchored proteins to spermatozoa on membranous vesicles invites reassessment of the situation of spermatozoa within the epididymis and their contact with membranous vesicles and merocrine secretions that may be crucial to promoting physiological changes in spermatozoa.