gebhart/patrepeval huggingface dataset:
Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro (1994)

Recombinant growth factors and proinflammatory cytokines were added to primary cultures of human intrahepatic biliary duct epithelia to test for their ability to stimulate DNA synthesis and elicit cytokine production. Interleukin-6 and hepatocyte and epidermal growth factors were found to increase the DNA labeling index of biliary duct epithelium from fourfold to sixfold 24 hr after their addition to primary biliary duct epithelium cultures maintained in serum-free medium. The proliferative responses to all three biliary duct epithelium mitogens peaked within 24 hr, and hepatocyte growth factor was effective over a concentration range of 1.0 to 50 ng/ml, whereas interleukin-6 was effective from 1 to 1,000 U/ml. Insulin-like growth factor, phorbol myristate acetate, interleukin-1 beta and platelet-derived growth factor BB showed mild stimulatory effects, whereas interleukin-4, gamma-interferon, phytohemagglutinin and platelet-derived growth factors AA and AB did not increase DNA synthesis in biliary duct epithelium. Interleukin-1 beta and phorbol myristate acetate were also shown to induce in a dose-dependent fashion a threefold to fivefold increase of interleukin-6 production as measured by enzyme-linked immunosorbent assay in human primary biliary duct epithelium cultures, when compared with hepatocyte growth factor, epidermal growth factor, insulin-like growth factor, phytohemagglutinin, tumor necrosis factor-alpha or platelet-derived growth factor. These results show that interleukin-6 participates in growth regulation of human biliary duct epithelium. This could be exerted in a paracrine or autocrine manner.(ABSTRACT TRUNCATED AT 250 WORDS)
A dynamic depletion SOI MOSFET model for SPICE (1998)

We show, using measurements, that a transition between partial and full depletion (PD and FD) modes of operation as terminal voltages vary with time (dynamic depletion) has a strong impact on thin film SOI MOSFET characteristics. A model incorporating this effect is presented. It includes floating body, backgate, and body contact nodes, as well as impact ionization, GIDL, diode leakage and parasitic bipolar currents. Self-heating is modeled by an auxiliary R/sub th/C/sub th/ circuit. The model uses a single smooth equation over all operating regimes for each current and charge and is fully scalable with T/sub si/, T/sub box/, T/sub ox/, W, and L.
Human disc cells in monolayer vs 3D culture: cell shape, division and matrix formation (2000)

The cell's in vivo interactions with the ECM can regulate shape, gene expression and other cell functions. The shape of the annulus cell changes markedly during life: the young, healthy disc contains spindle shaped cells and abundant collagen. With aging and degeneration, many cells assume a strikingly different appearance, become rounded and are surrounded by unusual accumulations of ECM products. In vitro manipulation of disc cells provides an experimental window for testing how disc cells from given individuals respond when they are grown in environments which direct cells to have either spindle- or rounded-shapes. In vitro assessment of the response of such cells to platelet-derived growth factor and to Matrigel(tm) showed a continued influence of cell shape even in the presence of a growth factor stimulus. These findings contribute new information to the important issue of the influence of cell shape on cell behavior.
Generalizability Theory: The Software Problem (1985)

This paper outlines the problems associated with the estimation of variance components in generalizability analyses using analysis of variance software, and discusses the most useful software currently available for this specialist application: the MIVQUE method of the SAS procedure VARCOMP.
Activation of rat liver phospholipase D by the small GTP-binding protein RhoA (1994)

Stimulation of phospholipase D by guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) in rat liver plasma membranes indicates the involvement of GTP-binding proteins. We used RhoGDI, an inhibitor of GDP dissociation from small GTP-binding proteins of the Rho family, to determine the involvement of these proteins. Incubation, and subsequent washing, of plasma membranes with RhoGDI dose-dependently diminished GTP gamma S-stimulated phospholipase D activity, as determined by accumulation of phosphatidylethanol in the presence of ethanol. Incubation with RhoGDI also caused a rapid and dose-dependent appearance of RhoA in the wash, which was associated with the inhibition of phospholipase D. RhoGDI also rapidly extracted Cdc42 from membranes, but Rac1 was not extracted. Full reconstitution of GTP gamma S-stimulated phospholipase D in RhoGDI-washed membranes was achieved with recombinant RhoA. There was partial reconstitution with Rac1 and no enhancement with Cdc42 or ADP-ribosylation factor. The response to RhoA was dose-dependent (EC50 = 0.5 microM). ADP-ribosylation of RhoA by Clostridium botulinum C3 exoenzyme did not affect its ability to recover GTP gamma S-stimulated phospholipase D activity in RhoGDI-washed membranes. These findings support a role for GTP-binding proteins of the Rho family in the activation of membrane-associated phospholipase D and implicate RhoA as the major protein involved.
Fluorographic detection of radioactivity in polyacrylamide gels with 2,5-diphenyloxazole in acetic acid and its comparison with existing procedures (1983)

A fluorographic procedure was optimized which utilized acetic acid as the solvent for 2,5-diphenyloxazole (PPO). This procedure was then compared with existing fluorographic procedures which utilize PPO in dimethyl sulphoxide or sodium salicylate in water, and a commercially available fluorographic solution. En3Hance (New England Nuclear Corp.). A comparison of the four methods revealed that all of the procedures resulted in essentially the same efficiency of radioactivity detection. The acetic acid/PPO procedure was found to have several technical advantages. There is no need to pre-fix proteins in gels, and either agarose or acrylamide gels can be used. The acetic acid/PPO procedure was found to be a simple, sensitive and efficient alternative fluorographic method.
Extremal transmission at the Dirac point of a photonic band structure (2007)

We calculate the effect of a Dirac point (a conical singularity in the band structure) on the transmission of monochromatic radiation through a photonic crystal. The transmission as a function of frequency has an extremum near the Dirac point, depending on the transparencies of the interfaces with free space. The extremal transmission ${T}_{0}={\ensuremath{\Gamma}}_{0}W∕L$ is inversely proportional to the longitudinal dimension $L$ of the crystal (for $L$ larger than the lattice constant and smaller than the transverse dimension $W$). The interface transparencies affect the proportionality constant ${\ensuremath{\Gamma}}_{0}$, and they determine whether the extremum is a minimum or a maximum, but they do not affect the ``pseudodiffusive'' $1∕L$ dependence of ${T}_{0}$.
Hyperthermia Protects Against Light Damage in the Rat Retina (1988)

An increase in the synthesis of heat shock proteins that is induced in cells in vitro by hyperthermia or other types of metabolic stress correlates with enhanced cell survival upon further stress. To determine if a similar increase in stress tolerance could be elicited in vivo, rats were made hyperthermic, and then their retinas were tested for sensitivity to light damage. This treatment resulted in a marked decrease in photoreceptor degeneration after exposure to bright light as compared to normothermic animals. Concomitant with such protection was an increase in retinal synthesis of three heat shock proteins. Thus, a physiological rise in body temperature enhances the stress tolerance of nerve tissue, perhaps by increasing heat shock protein production.
Adaptive regularization using the entire solution surface (2009)

Several sparseness penalties have been suggested for delivery of good predictive performance in automatic variable selection within the framework of regularization. All assume that the true model is sparse. We propose a penalty, a convex combination of the <i>L</i><sub>1</sub>- and <i>L</i><sub>∞</sub>-norms, that adapts to a variety of situations including sparseness and nonsparseness, grouping and nongrouping. The proposed penalty performs grouping and adaptive regularization. In addition, we introduce a novel homotopy algorithm utilizing subgradients for developing regularization solution surfaces involving multiple regularizers. This permits efficient computation and adaptive tuning. Numerical experiments are conducted using simulation. In simulated and real examples, the proposed penalty compares well against popular alternatives.
Determination of Eye Torsion by Videooculography Including Cornea Optics (2006)

Influence of optical characteristics of cornea on formation of image of iris and its signature is evaluated. A mathematical model of optical characteristics of cornea is created for this purpose. The nature of changes in geometric parameters of pupil, iris and its signature images, when the rotation of eye is performed, is analyzed. We concluded that optical characteristics of cornea influence iris and its signature images and those distortions should be considered when calculating torsion by the method of correlation of signature of iris. Original videooculography method to register torsional movements of human is created. It evaluates the influence of optical characteristics of cornea on the image of iris. This model reduces standard deviation of points on Listing planes on average by approximately 14% in comparison with previously used methods. Thus, it is significant to consider the influence of optical characteristics of cornea on image of iris when calculating torsional eye movements by the method of correlation of signature of iris. Ill. 8, bibl. 7 (in English; summaries in English, Russian and Lithuanian).
3D object tracking using RGB and LIDAR data (2016)

Object tracking is one of the key components of the perception system of autonomous cars and ADASs. With tracking, an ego-vehicle can make a prediction about the location of surrounding objects in the next time epoch and plan for next actions. Object tracking algorithms typically rely on sensory data (from RGB cameras or LIDAR). In fact, the integration of 2D-RGB camera images and 3D-LIDAR data can provide some distinct benefits. This paper proposes a 3D object tracking algorithm using a 3D-LIDAR, an RGB camera and INS (GPS/IMU) sensors data by analyzing sequential 2D-RGB, 3D point-cloud, and the ego-vehicle's localization data and outputs the trajectory of the tracked object, an estimation of its current velocity, and its predicted location in the 3D world coordinate system in the next time-step. Tracking starts with a known initial 3D bounding box for the object. Two parallel mean-shift algorithms are applied for object detection and localization in the 2D image and 3D point-cloud, followed by a robust 2D/3D Kalman filter based fusion and tracking. Reported results, from both quantitative and qualitative experiments using the KITTI database demonstrate the applicability and efficiency of the proposed approach in driving environments.
Involvement of FLIP in 2-Methoxyestradiol–Induced Tumor Regression in Transgenic Adenocarcinoma of Mouse Prostate Model (2009)

Targeting Sp1-mediated FLIP signaling pathway may provide a novel approach for prostate cancer management.
Protein Tyrosine Phosphatases Are Up-regulated and Participate in Cell Death Induced by Polyglutamine Expansion (2002)

Polyglutamine expansion is the cause of several neurodegenerative diseases. An in vitro model of polyglutamine-induced neuronal cell death was developed using truncated mutant huntingtin (Htt) and PC12 cells. Cell death was specifically observed in cells expressing a truncated mutant huntingtin-green fluorescence protein (GFP) fusion protein with 118 glutamine repeats (Gln(118)), as demonstrated by the release of lactate dehydrogenase (LDH). To gain further insights into the mechanisms of polyglutamine expansion-induced cell death, the Affymetrix rat genome array U34A was used to investigate gene expression changes associated with polyglutamine-mediated protein aggregation and cell death. Among the up-regulated genes, the increase of four protein tyrosine phosphatases (PTPs) was further confirmed by real-time quantitative reverse transcription PCR. Protein expression of mitogen activated protein (MAP) kinase phosphatase 1 (MKP1) was also increased as demonstrated by Western blot. Furthermore, phosphorylation of MAP kinase extracellular signal-regulated kinase 1/2 (ERK1/2) was substantially reduced in association with protein aggregation, and two general PTP inhibitors, sodium orthovanadate and bpV(pic), dramatically rescued the cells from polyglutamine-induced cell death. These results suggest that one or more of the PTPs are involved in the polyglutamine-induced cell death.
Participation of Hyaluronic Acid in the Macrophage Disappearance Reaction (1980)

Hyaluronic acid accumulates in the peritoneal cavity of mice during the macrophage disapperance reaction. Macrophages reappear in the exudates during the depletion of hyaluronate. The disappearance reaction is simulated by the intraperitional (i.p.) injection of hyaluronic acid into normal mice. The disapperance reaction largely is inhibited by the simultaneous injection (i.p.) of specific hyaluronidase with the challenge dose of BCG. We propose that hyaluronic acid makes a major contribution to the macrophage disappearance reaction.
Email Analytics for Activity Management and Insight Discovery (2013)

Emails constitute the bulk of all official communications in any organization. Email repositories are tacit store-houses of knowledge about people, projects and processes. Mining one's own email repository can also provide interesting and valuable insights about his or her engagements and contacts along different dimensions. In this paper, we propose an email analytics framework that combines text-mining, network analysis and data analytics principles to mine email repositories for useful insights. While individuals are more attuned to looking at emails as individual items along with a history that is embedded in the trail, mining the whole collection can also lead to knowledge-discovery about similarities and dissimilarities of different engagements. This in turn can lead to valuable information like comparative status reports on various projects or deeper insights about why certain projects succeed while others don't. Given the volumes, diversity and noisy nature of e-mails, it becomes impossible for human beings to comprehend the impact of all of it unless the task is automated and approached in a structured fashion. We show that combination of text and network analytics along with temporal reasoning can provide valuable insights about task-states, actionable items, recommendations and forecasts. These insights can be exploited very effectively for project-management tasks like automated identification of bottlenecks or their causes, elimination of inefficiencies, early-warnings and suggestions about proactive measures to avoid problems. It is possible to extend the framework quite easily to analyze multiple email repositories of different users, though this work does not address the privacy or security concerns that might exist.
Notes: Simple Method for Removal of Peroxides from Diethyl Ether (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes: Simple Method for Removal of Peroxides from Diethyl EtherRobert FeinsteinCite this: J. Org. Chem. 1959, 24, 8, 1172–1173Publication Date (Print):August 1, 1959Publication History Published online11 July 2003Published inissue 1 August 1959https://pubs.acs.org/doi/10.1021/jo01090a636https://doi.org/10.1021/jo01090a636research-articleACS PublicationsRequest reuse permissionsArticle Views673Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Social competence and observer‐rated social functioning in bipolar disorder (2010)

Our study confirmed the negative relationship of bipolar depression with social functioning. A subgroup of outpatients with bipolar disorder has impaired social competence, which, when present, worsened the impact of depression and cognitive impairment on social functioning.
Improved chemical vapour deposition method for long-length optical fibre (1978)

The deformation of the supporting tube during the c.v.d. process for optical fibre fabrication is completely suppressed by controlling the internal pressure of the tube. A 14 km length single-mode fibre with attenuation loss of about 3.2 dB/km at 0.85 μm was fabricated by this improved method.
Consumer activity in social media: Managerial approaches to consumers' social media behavior (2011)

ABSTRACT Today, consumers are involved in a variety of activities, ranging from consuming content to participating in discussions, sharing knowledge with other consumers, and contributing to other consumers' activities. With the enormous interest in social media sites, such as YouTube, MySpace, Facebook, and Wikipedia, consumers are assumed to be actively contributing to marketing content. However, despite the rich opportunities for contributing, recent academic research indicates that consumers are not necessarily as active online as has been believed. The aim of this paper is to conceptualize consumers' activities in social media by examining the motivations behind the activities. By offering a more detailed description of the differences in consumer use of social media, the study extends existing research on consumer activities related to user‐created content. Based on consumer narratives of their social media activity, we identified 15 activities grouped under three themes. The conceptual framework is used to suggest managerial strategies related to different levels of consumer activity. Thus, it provides a tool for uncovering managerial challenges and for planning responses to consumer activities. Copyright © 2011 John Wiley & Sons, Ltd.
LSO-Based Single Crystal Film Scintillator for Synchrotron-Based Hard X-Ray Micro-Imaging (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> X-ray detector systems are powerful tools: in combination with tomographic methods they provide volumetric data of samples in a non-destructive manner which is of high interest for, e.g., biology, medicine or materials research. The detector able to provide images with submicrometer spatial resolution frequently consists of a scintillator screen, light microscopy optics and a digital camera. Here, the scintillator converts the X-rays into a visible light image which is projected onto the camera by the light optics. In order to perform high resolution imaging Single Crystal Film (SCF) scintillators 1 <formula formulatype="inline"><tex Notation="TeX">$\mu{\rm m}$</tex></formula> to 30 <formula formulatype="inline"><tex Notation="TeX">$\mu{\rm m}$</tex></formula> thin are required due to the limited depth of focus of the microscopy optics. Thin SCFs can be obtained via liquid phase epitaxy (LPE). A drawback is that a detector working with SCFs suffers from low efficiency (2% at 50 keV) owing to their limited thickness. The detective quantum efficiency (DQE) is here mainly limited by the low absorption of X-rays and the light yield in the thin scintillator layer. Performances, i.e absorption, light yield, afterglow of operational systems at the European Synchrotron Radiation Facility (ESRF) using YAG:Ce (<formula formulatype="inline"><tex Notation="TeX">${\rm Y} _{3} {\rm Al} _{5} {\rm O} _{12}$</tex></formula>:Ce), LAG:Eu (<formula formulatype="inline"> <tex Notation="TeX">${\rm Lu} _{3} {\rm Al} _{5} {\rm O} _{12}$</tex></formula>:Eu) and GGG:Eu (<formula formulatype="inline"><tex Notation="TeX">${\rm Gd} _{3} {\rm Ga} _{5} {\rm O}_{12}$</tex></formula>:Eu) scintillators <citerefgrp> <citeref refid="ref1"/></citerefgrp> will be presented and compared to new LSO:Tb (<formula formulatype="inline"><tex Notation="TeX">${\rm Lu} _{2} {\rm SiO} _{5}$</tex></formula>:Tb) scintillators developed in the framework of an European project <citerefgrp><citeref refid="ref2"/></citerefgrp>, <citerefgrp> <citeref refid="ref3"/></citerefgrp>. A new concept to improve the efficiency of detection in the 20 keV – 40 keV energy range with 1 <formula formulatype="inline"><tex Notation="TeX">$\mu{\rm m}$</tex></formula> spatial resolution will be presented. This concept based on multilayer scintillators is realised by the LPE process as well. First results will be illustrated with X-ray images and will demonstrate the absorption efficiency improvement of the X-ray detector. The expected performance is 7 times better than the LAG-based scintillators. </para>
Solubility and Phase Diagram of the Liquid O3–CF4 System (1963)

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Verbesina Section Ximenesia (Compositae): Biosystematics and Adaptive Variation (1974)

Section Ximenesia is native to the southwestern United States and northern Mexico. Two of its taxa, Verbesina encelioides subsp. exauriculata and V. nana, are more western and occur in arid or semiarid regions, whereas the third taxon, V. encelioides subsp. encelioides, is more eastern and occurs in relatively moist regions. A crossing program revealed the absence of isolating barriers between the subspecies of V. encelioides. It is suggested that V. encelioides and V. nana are effectively isolated genetically by differences in ploidy. The study of several morphological characters of both field-collected and garden-grown populations indicates that differential adaptation for aridity has been of primary importance in the evolution of section Ximenesia. The taxa occupying arid regions show a reduction of transpiring surface, reduced reproductive capacity, and reduced dispersibility.