gebhart/patrepeval huggingface dataset:
METALLURGY DIVISION QUARTERLY PROGRESS REPORT FOR PERIOD ENDING OCTOBER 31, 1952 (1960)

Physieal Metallurgy. In the study of Th alloys, it has been found that the addition of Nb and V to Th produces a slight strengthening effect with the first small additions, but that large additions result in a lowering of strength with corresponding increases in ductility. The melting point of iodide Th was measured as being 1755 deg C. Studies of a series of Th--C alloys, with C content up to 0.13%, indicate that C does not affect the temperatures for the start and completion of recrystallization. ANP Program. Welding specifications were prepared for the joining of Inconel pipe dan fitting. for use with highly corrosive media. The production of spherical particles of alloys of U with Ni, V, Nb, and Mo is being studied. The effect of small differences in test temperature in the stress-rupture life and creep rate of Inconel was studied. The effect of different cleaning procedures on the corrosive action of the fluorides on Inconel is being studied. Additional static and dynamic tests were run in an attempt to find inhibitors for the mass transfer and corrosion exhibited in the metal-hydroxide systems. The study of the compounds formed by the interaction of Ni in the hydroxides has shown the appearance of two new compounds: NaNiO/sub 2/ and LiNiO/sub 2/. Ceramics Research. A ceramic coating was successfully applied to Ni, and a Ni radiator assembly is being coated for the ANP Project. A technique for the synthesis of hafnium carbide was developed. Fabrication Research. Production of enriched U fuel and control red elements for operation of the MTR is described. (W.L.H.)
Asymptotic analysis of the conventional decision feedback receiver in flat fading channels (2003)

The spectral efficiency presents the ultimate limit on the data rate per unit bandwidth of a certain communication system. For the DS-CDMA systems spectral efficiency has been derived for optimal and linear multiuser receivers in the case of synchronous reception, fading and non-fading environment as well as single and multi-cell cellular networks. The most pervasive model employed in all these analyses is the large system random signature model. For the decision feedback receivers the previous research handled only the non-fading case while the case of fading channels remained unknown. This paper analyses the spectral efficiency of the decision feedback receiver in a fading channel with and without power ordering. The results show that in the case of power ordering before cancellation the multiuser diversity effect previously encountered by S. Shamai (Shitz) and Verdu (see IEEE Trans. on Inform. Theory, vol.47, p.1302-27, May 2001) occurs. Multiuser diversity is the effect where the spectral efficiency of a certain multiple-access system improves in fading channels due to the multiplicity of users that share the system and provide the necessary power diversity. Also, analyzed in this paper is the case of imperfectly estimated channel gains in fading environments or the case of imperfect power control. The spectral efficiency loss incurred by this estimation error is analyzed in the case of the conventional decision feedback receiver.
Phase-Diagram Considerations of Cluster Formation When Using Nozzle-Beam Sources (1989)

In order to help understand the formation of clusters when using nozzle-beam sources, procedures for constructing and applying isentropicexpansion paths on the pressure-temperature phase diagram for the beam gas are summarized and exemplified for the case of He. The importance of using real-fluid properties in constructing expansion paths is emphasized. In the case of He, it is found that, for a significant fraction of interesting source conditions, the real-fluid properties result in isentropic paths approaching the vaporliquid line from the liquid side. Procedures for identifying appropriate source conditions for specific goals, such as expanding through the critical point, approaching the vapor-liquid line from the liquid side, and locating the beginning of phase transition relative to the orifice, are included. Recent observations of the properties of He clusters produced using a low-temperature nozzlebeam source are discussed with the aid of an appropriate phase diagram.
Spinocerebellar Ataxia and HLA Linkage (1977)

To determine the possibility of genetic linkage of spinocerebellar ataxia with the histocompatibility loci, we performed HLA typing and linkage analysis on 19 members of a kindred in which spinocerebellar ataxia was segregating in an autosomal dominant inheritance pattern. The ataxia locus was located on chromosome 6 at 12-cM distance from the HLA complex with lod score of 3.15 (odds is greater than 1400:1 favoring linkage over chance findings). Thus, the presence of the ataxia gene in members of this kindred at risk can be predicted with about 90 per cent accuracy by means of HLA typing in informative matings.
Programmed Cell Death of Embryonic Motoneurons Triggered through the FAS Death Receptor (1999)

About 50% of spinal motoneurons undergo programmed cell death (PCD) after target contact, but little is known about how this process is initiated. Embryonic motoneurons coexpress the death receptor Fas and its ligand FasL at the stage at which PCD is about to begin. In the absence of trophic factors, many motoneurons die in culture within 2 d. Most (75%) of these were saved by Fas-Fc receptor body, which blocks interactions between Fas and FasL, or by the caspase-8 inhibitor tetrapeptide IETD. Therefore, activation of Fas by endogenous FasL underlies cell death induced by trophic deprivation. In the presence of neurotrophic factors, exogenous Fas activators such as soluble FasL or anti-Fas antibodies triggered PCD of 40-50% of purified motoneurons over the following 3-5 d; this treatment led to activation of caspase-3, and was blocked by IETD. Sensitivity to Fas activation is regulated: motoneurons cultured for 3 d with neurotrophic factors became completely resistant. Levels of Fas expressed by motoneurons varied little, but FasL was upregulated in the absence of neurotrophic factors. Motoneurons resistant to Fas activation expressed high levels of FLICE-inhibitory protein (FLIP), an endogenous inhibitor of caspase-8 activation. Our results suggest that Fas can act as a driving force for motoneuron PCD, and raise the possibility that active triggering of PCD may contribute to motoneuron loss during normal development and/or in pathological situations.
Modified Dendrimer Cross-Linked Collagen-Based Matrices (2012)

Dendrimer cross-linking has been achieved with pepsin digested over 80% type-I bovine collagen to create strong hydrogels with good cell compatibility. Herein we investigate the use of commercially available collagen-based products with the dendrimer cross-linking technology. Specifically PureCol(®) (PC), a 97% bovine type-I collagen, human collagen (HC) and human extracellular matrix (hECM) were concentrated, and then cross-linked with polypropyleneimine octaamine generation two dendrimers using 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) chemistry. PC gels with 30 and 20 mg/ml bovine collagen were fabricated, and despite similar concentrations to >80% type-I bovine collagen dendrimer cross-linked gels (CG), PC gels demonstrated increased swelling and decreased stability, as determined with collagenase digestion. The highly purified bovine (PC) and human sourced-collagen (HC) gels were similar in performance, but not as stable as the CG gels, which may correlate to the manufacturer's collagen purification and storage. Finally, the addition of hECM components to PC to create PC-hECM gels, resulted in a looser gel network, compared to heparinized dendrimer cross- linked bovine >80% type-I collagen gels (CHG). However, all collagen-based gels supported 3T3 fibroblast cell growth over 4 days, indicating these gels may be suitable for tissue-engineering applications.
Mucocutaneous fungal colonization in HIV-infected children. (1995)

The prevalence of symptomatic mucocutaneous candidiasis in HIV-infected children is well documented. Information, however, of the carriage rate of potential fungal pathogens is lacking. In this study we determined the fungal colonization rate of multiple mucocutaneous sites from 13 HIV-infected and 12 control children. The rate of yeast and mould colonization and the species of fungal isolates were essentially the same for both groups of patients. However, several HIV-infected children asymptomatic for thrush proved to be colonized by Candida albicans, and disseminated colonization with Trichosporon beigelii occurred in one HIV-infected child. All cultures for dermatophytes were negative. While the carriage rate with fungi other than C. albicans was not increased in the HIV-infected group, the isolates recovered are known pathogens in the immunocompromised host and the colonization of these organisms may be a potential source of infection.
Structure and Properties of <i>fac</i>-[Re<sup>I</sup>(CO)<sub>3</sub>(NTA)]<sup>2–</sup> (NTA<sup>3–</sup> = Trianion of Nitrilotriacetic Acid) and <i>fac</i>-[Re<sup>I</sup>(CO)<sub>3</sub>(L)]<sup>n–</sup> Analogues Useful for Assessing the Excellent Renal Clearance of the <i>fac-</i>[<sup>99m</sup>Tc<sup>I</sup>(CO)<sub>3</sub>(NTA)]<sup>2–</sup> Diagnostic Renal Agent (2015)

We previously identified two new agents based on the [(99m)Tc(V)O](3+) core with renal clearances in human volunteers 30% higher than that of the widely used clinical tracer (99m)Tc-MAG3 (MAG3(5-) = penta-anion of mercaptoacetyltriglycine). However, renal agents with even higher clearances are needed. More recently, we changed our focus from the [(99m)Tc(V)O](3+) core to the discovery of superior tracers based on the fac-[(99m)Tc(I)(CO)3](+) core. Compared to (99m)Tc-MAG3, fac-[(99m)Tc(I)(CO)3(NTA)](2-) (NTA(3-) = trianion of nitrilotriacetic acid) holds great promise by virtue of its efficient renal clearance via tubular secretion and the absence of hepatobiliary elimination, even in patients with severely reduced renal function. We report here NMR, molecular (X-ray) structure, and solution data on fac-[Re(I)(CO)3(NTA)](2-) with a -CH2CO2(-) dangling monoanionic chain and on two fac-[Re(I)(CO)3(L)](-) analogues with either a -CH2CONH2 or a -CH2CH2OH dangling neutral chain. In these three fac-[Re(I)(CO)3(L)](n-) complexes, the fac-[Re(I)(CO)3(N(CH2CO2)2)](-) moiety is structurally similar and has similar electronic properties (as assessed by NMR data). In reported and ongoing studies, the two fac-[(99m)Tc(I)(CO)3(L)](-) analogues with these neutral dangling chains were found to have pharmacokinetic properties very similar to those of fac-[(99m)Tc(I)(CO)3(NTA)](2-). Therefore, we reach the unexpected conclusion that in fac-[(99m)Tc(I)(CO)3(L)](n-) agents, renal clearance is affected much more than anticipated by features of the core plus the chelate rings (the [(99m)Tc(I)(CO)3(N(CH2CO2)2)](-) moiety) than by the presence of a negatively charged dangling carboxylate chain.
Launching the yeast 23S RNA Narnavirus shows 5′ and 3′ cis-acting signals for replication (2003)

Narnavirus 23S RNA is a persistent positive-stranded RNA virus found in yeast Saccharomyces cerevisiae. The viral genome (2.9 kb) only encodes its RNA-dependent RNA polymerase, p104. Here we report the generation of 23S RNA virus, with high frequency, from a vector containing the entire viral cDNA sequence. When the conserved GDD (Gly-Asp-Asp) motif of RNA-dependent RNA polymerase was modified, the vector failed to generate the virus, indicating that an active p104 is essential for replication. Successful launching required transcripts having the proper viral 3' terminus generated in vivo. This was accomplished through in vivo processing of the primary transcripts by the hepatitis delta virus antigenomic ribozyme directly fused to the 3' terminus of the 23S RNA genome. Although the primary transcripts also contained extra nucleotides at their 5' ends derived from the vector, the launched virus possessed the authentic 5' terminus of the viral genome without these extra nucleotides. Modifications of the genome sequence at the 5' and 3' termini abolished viral generation, indicating that the viral genome has cis-acting signals for replication at both termini. The great ease to generate the virus will facilitate the identification of these cis-acting signals. Furthermore, the virus, once generated, can be transmitted to daughter cells indefinitely without the vector or any selection, which makes the 23S RNA virus-launching system particularly useful for investigating the basis for RNA virus persistence.
Altruistic scheduling in multi-resource clusters (2016)

Given the well-known tradeoffs between fairness, performance, and efficiency, modern cluster schedulers often prefer instantaneous fairness as their primary objective to ensure performance isolation between users and groups. However, instantaneous, short-term convergence to fairness often does not result in noticeable long-term benefits. Instead, we propose an altruistic, long-term approach, CARBYNE, where jobs yield fractions of their allocated resources without impacting their own completion times. We show that leftover resources collected via altruisms of many jobs can then be rescheduled to further secondary goals such as application-level performance and cluster efficiency without impacting performance isolation. Deployments and large-scale simulations show that CARBYNE closely approximates the state-of-the-art solutions (e.g., DRF [27]) in terms of performance isolation, while providing 1:26× better efficiency and 1:59× lower average job completion time.
Does submucosal diathermy to the inferior turbinates reduce nasal resistance to airflow in the long term? (1987)

The operation of submucosal diathermy is commonly performed for the relief of nasal obstruction due to mucosal swelling. In this study the effect of the procedure on nasal resistance to airflow is assessed by rhinomanometry. The results show that although the operation is effective in the short term (two months), there is no significant difference between the nasal resistances prior to surgery and at 15 months after surgery.
Modeling of silane pyrolysis in a continuous flow reactor. Low-Cost Solar Array Project (1979)

Silane pyrolysis in a continuous flow pyrolyzer is a simple process that is currently being developed for producing solar cell grade silicon. The process involves complex phenomena, however, including thermal decomposition of silane, nucleation and growth of silicon particles, and mass and heat transfer. Modeling the effects of transport phenomena on silane pyrolysis in a continuous flow pyrolyzer is discussed. One- and two-dimensional models are developed to predict velocity, temperature, and concentration profiles in the reactor. The one-dimensional model has been implemented as a computer code.
Mechanism of action of nicotine in isolated urinary bladder of guinea‐pig (1988)

1. Nicotine produced a transient contraction of isolated strips of guinea-pig urinary bladder. The response to nicotine was antagonized by the nicotinic receptor antagonist, hexamethonium but was insensitive to tetrodotoxin. 2. The nicotine-induced contraction was potentiated by the cholinesterase inhibitor, physostigmine, and was reduced to 50% and 70% by the muscarinic cholinoceptor antagonist, atropine and the sympathetic neurone blocking drug, guanethidine, respectively. Chemical denervation with 6-hydroxydopamine abolished the inhibitory effect of guanethidine. Simultaneous treatment with atropine and guanethidine did not abolish the response to nicotine, but the degree of inhibition was comparable to that obtained with atropine alone. 3. The nicotine-induced contraction was insensitive to bunazosin and yohimbine (alpha 1- and alpha 2-adrenoceptor antagonists, respectively), and exogenously applied noradrenaline did not cause a contraction even in the presence of blockade of noradrenaline uptake mechanisms with desipramine and normetanephrine and of beta-adrenoceptors with propranolol, suggesting a non-adrenergic nature of the sympathomimetic effect of nicotine in this tissue. 4. The nicotine-induced contraction in the presence of atropine was abolished after desensitization of P2-purinoceptors with alpha, beta-methylene adenosine 5'-triphosphate, a slowly degradable ATP analogue selective for P2-purinoceptors. By this desensitization, the response to ATP, but not to histamine, was also abolished. 5. A cyclo-oxygenase inhibitor flurbiprofen partially inhibited the nicotine-induced contraction. The degree of the inhibition was more pronounced in the presence of atropine than in its absence. Flurbiprofen antagonized the response to exogenously applied ATP in an unsurmountable manner, but not that to carbachol. 6. The present results suggest that nicotine might induce a contraction through an interaction with nicotinic receptors located on the terminals of, possibly, (i) parasympathetic cholinergic, (ii) sympathetic non-adrenergic and (iii) non-sympathetic purinergic nerves in guinea-pig detrusor preparations, and that a portion of the contraction due to the purine nucleotide released is possibly potentiated by intramural prostaglandin(s). Parasympathetic cholinergic output might be modulated by an unknown excitatory substance released by nicotine from sympathetic nerve. 7. Nicotine reveals a latent excitatory effect of the sympathetic hypogastric nerve which innervates guinea-pig detrusor.
Optimization Strategies for Integration Pattern Compositions (2018)

Enterprise Application Integration is the centerpiece of current on-premise, cloud and device integration scenarios. We describe optimization strategies that help reduce the model complexity, and improve the process execution using design time techniques. In order to achieve this, we formalize compositions of Enterprise Integration Patterns based on their characteristics, and propose a realization of optimization strategies using graph rewriting. The framework is successfully evaluated on a real-world catalog of pattern compositions, containing over 900 integration scenarios.
Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E‐related disorders in humans (2001)

Apolipoprotein E (apo E) deficiency (or its abnormalities in humans) is associated with a series of pathological conditions including dyslipidemia, atherosclerosis, Alzheimer's disease, and shorter life span. The purpose of this study was to characterize these conditions in apo E-deficient C57BL/6J mice and relate them to human disorders. Deletion of apo E gene in mice is associated with changes in lipoprotein metabolism [plasma total cholesterol (TC) (>+400%), HDL cholesterol (-80%), HDL/TC, and HDL/LDL ratios (-93% and -96%, respectively), esterification rate in apo B-depleted plasma (+100%), plasma triglyceride (+200%), hepatic HMG-CoA reductase activity (-50%), hepatic cholesterol content (+30%)], decreased plasma homocyst(e)ine and glucose levels, and severe atherosclerosis and cutaneous xanthomatosis. Hepatic and lipoprotein lipase activities, hepatic LDL receptor function, and organ antioxidant capacity remain unchanged. Several histological/immunohistological stainings failed to detect potential markers for neurodegenerative disease in the brain of 37-wk-old male apo E-KO mice. Apo E-KO mice may have normal growth and development, but advanced atherosclerosis and xanthomatosis may indirectly reduce their life span. Apo E plays a crucial role in regulation of lipid metabolism and atherogenesis without affecting lipase activities, endogenous antioxidant capacity, or appearance of neurodegenerative markers in 37-wk-old male mice.
Adult Reproductive Tract Morphology and Spermatogenesis in the Black Soldier Fly (Diptera: Stratiomyidae) (2019)

Abstract Large-scale production of the black soldier fly [Hermetia illucens (L.) (Diptera: Stratiomyidae)] for use as aquaculture and poultry feed has developed into a global industry. Successful commercialization of the black soldier fly relies on optimizing the production of fecund adults. However, current mass-rearing protocols result in variable production of fertile eggs. To help lay a foundation for a better understanding of factors that may play a role in this variability, the morphology of the black soldier fly male reproductive tract and spermatozoa, associated spermatogenesis process, impact of age on the process, and the female spermatheca morphology were examined with various microscopic techniques (e.g., scanning electron microscope, transition electron microscope, and dissecting scope). The gross morphology of the male reproductive tract and female spermatheca appear to be similar to those found in other brachyceran flies. Male spermatozoa are long (~860 µm overall, ~8 µm head), apparently motile, and possess flagella with a typical 9 + 9 + 2 axoneme triplets. Germ cells go through incomplete mitotic divisions surrounded by somatic cyst cells in the testes. Spermatogenesis appears to be initiated during immature development (cryptocephalic pupa stage). From <24 h to 7 d post-emergence, male aging appeared to impact sperm production.
Sensitivity enhancement of nanoplasmonic sensors in low refractive index substrates (2009)

Metal films perforated by nanoholes constitute a powerful platform for surface plasmon resonance biosensing. We find that the refractive index sensitivity of nanohole arrays increases if their resonance is red-shifted by increasing the separation distance between holes. However, an additional sensitivity enhancement occurs if the nanohole sensors are manufactured on low index substrates, despite the fact such substrates significantly blue-shift the resonance. We find a approximately 40% higher bulk refractive index sensitivity for a system of approximately 100 nm holes in 20 nm gold films fabricated on Teflon substrates (n=1.32) compared to the case when conventional glass substrates (n=1.52) are used. A similar improvement is observed for the case when a thin layer of dielectric material is deposited on the samples. These results can be understood by considering the electric field distribution induced by the so-called antisymmetric surface plasmon polariton in the thin gold films.
Bimatoprost and Bimatoprost/Timolol Fixed Combination in Patients with Open-Angle Glaucoma and Ocular Hypertension (2011)

Both BIM 0.03% and the BTFC were effective in lowering IOP in eyes with ocular hypertension and open-angle glaucoma. However, the fixed combination provided an additional statistically significant reduction in IOP compared with BIM 0.03%.
Raman fibre laser operating at 1.24 µm (1998)

A compact and efficient cascaded Raman fibre laser based on fused fibre couplers pumped by a diode-pumped ytterbium-doped fibre laser is demonstrated. The results obtained from its application to various Raman amplifier configurations at 1300 nm are reported.
Identification of the rat epididymis-secreted 4E9 antigen as protein E: Further biochemical characterization of the highly homologous epididymal secretory proteins D and E (1996)

Epididymis-secreted proteins D and E have been purified to homogeneity and partially characterized, and it is shown that monoclonal antibody (MAb) 4E9 (raised against a detergent extract of rat caudal epididymal sperm [Moore et al., 1994: Mol Reprod Dev 37(2):181-194]) recognizes protein E, but not protein D. The molecular weight of protein D (approximately 30 kD) is approximately 2 kD lower than protein E (approximately 32 kD). The NH2-terminus of each protein is blocked; however, microsequencing of internal peptides confirms earlier reports of significant sequence identity between the two proteins. High performance liquid chromatography tryptic peptide mapping showed peak differences between the two proteins, but it was not possible to obtain amino acid sequence in the peaks that were different. The epitope for MAb 4E9 was localized in the blocked NH2-terminus-CNBr peptide derived from protein E. The epitope was destroyed by protease treatment of protein E. Removal of N-linked oligosaccharides did not destroy the epitope for MAb 4E9 and did not affect the molecular weight difference between the proteins.