gebhart/patrepeval huggingface dataset:
RETRACTED: LKB1 and AMPK maintain epithelial cell polarity under energetic stress (2007)

LKB1 is mutated in both familial and spontaneous tumors, and acts as a master kinase that activates the PAR-1 polarity kinase and the adenosine 5'monophosphate-activated kinase (AMPK). This has led to the hypothesis that LKB1 acts as a tumor suppressor because it is required to maintain cell polarity and growth control through PAR-1 and AMPK, respectively. However, the genetic analysis of LKB1-AMPK signaling in vertebrates has been complicated by the existence of multiple redundant AMPK subunits. We describe the identification of mutations in the single Drosophila melanogaster AMPK catalytic subunit AMPKalpha. Surprisingly, ampkalpha mutant epithelial cells lose their polarity and overproliferate under energetic stress. LKB1 is required in vivo for AMPK activation, and lkb1 mutations cause similar energetic stress-dependent phenotypes to ampkalpha mutations. Furthermore, lkb1 phenotypes are rescued by a phosphomimetic version of AMPKalpha. Thus, LKB1 signals through AMPK to coordinate epithelial polarity and proliferation with cellular energy status, and this might underlie the tumor suppressor function of LKB1.
Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence (1981)

We studied the effects of leukotrienes on in vitro functions of neutrophil polymorphonuclear (PMN) granulocytes. Leukotriene B4 (LTB4) evoked a stimulated and directed migration of neutrophils under agarose with an optimum concentration of 10(-6)M, whereas two nonenzymatically formed isomers (compounds I and II) induced this response at 10(-5)M. Leukotriene C4 (LTC4) and 5-hydroxyeicosate-traenoic acid (5-HETE) did not affect this PMN migration. At the same optimum concentrations, LTB4 and compounds I and II augmented PMN adherence to nylon fibers. The chemotactic and adherence responses were of the same magnitude as with formal-Met-Leu-Phe (fMLP) at 10(-7)M. None of the leukotrienes influenced the spontaneous or phagocytosis-associated chemiluminescence or the ability to kill Staphylococcus aures. The cyclooxygenase inhibitor, indomethacin, inhibited only partly the fMLP-induced migration at high concentrations and stimulated migration at 2.5 x 10(-7)M, suggesting that arachidonic acid was then mainly metabolized by the lipoxygenase pathways. The lipoxygenase and cyclooxygenase inhibitor, eicosatetraynoic acid, inhibited both spontaneous and stimulated migration at greater or equal to 2.5 x 10(-5)M, but not at lower concentrations. Thus, since LTB4, and to a lesser degree compounds I and II, stimulated migration and adhesion, it is suggested that these mediators could be of importance for the emigration of neutrophils from blood vessels to areas of inflammation.
A computationally efficient Doppler compensation system for underwater acoustic communications (2000)

A Doppler compensation system is presented which is suitable for high-data-rate acoustic communication between rapidly moving platforms such as autonomous underwater vehicles. The proposed approach provides a generic preprocessor to conventional adaptive receiver structures with only a marginal increase in computational load and hardware cost. The preprocessor employs a novel Doppler estimation technique and efficient sample rate conversion to remove Doppler shift induced by platform velocity and acceleration. Performance predicted by simulation is compared to that of sea trials of a prototype communication system in the North Sea. Successful communication is demonstrated at 16 kbit/s with a transmitting platform moving at up to /spl plusmn/2.6 m/s.
Polyamine-Mediated Resistance of Uropathogenic <i>Escherichia coli</i> to Nitrosative Stress (2006)

During the course of a urinary tract infection, substantial levels of nitric oxide and reactive nitrogen intermediates are generated. We have found that many uropathogenic strains of Escherichia coli display far greater resistance to nitrosative stress than the K-12 reference strain MG1655. By selecting and screening for uropathogenic E. coli transposon mutants that are unable to grow in the presence of acidified nitrite, the cadC gene product was identified as a key facilitator of nitrosative stress resistance. Mutation of cadC, or its transcriptional targets cadA and cadB, results in loss of significant production of the polyamine cadaverine and increased sensitivity to acidified nitrite. Exogenous addition of cadaverine or other polyamines rescues growth of cad mutants under nitrosative stress. In wild-type cells, the concentration of cadaverine produced per cell is substantially increased by exposure to acidified nitrite. The mechanism behind polyamine-mediated rescue from nitrosative stress is unclear, but it is not attributable solely to chemical quenching of reactive nitrogen species or reduction in mutation frequency.
SURFACE SOIL STABILIZATION BASICS (1989)

Soil stabilization can be defined by the function of the improved soils. Those functions include surface stabilization, slope stabilization, and deep stabilization. This article covers surface stabilization, which is defined as the hardening of surface soils with various binders such as lime, cement, fly ash and asphalt. Such hardening increases the load bearing strengths of soils and permits them to carry the weight of a new facility (highway, airfield, etc.). It also provides a firm work platform for the contractor during construction. Included in the article is information on the use of lime, cement, fly ash, asphalt, polymers, and geotextiles for stabilization. Construction methods are also described.
Single-chip Integration of SRAM and Non-volatile Memory using Bit-line Sharing (2006)

A new memory architecture integrating SRAM and Flash within the same array is presented and demonstrated in a standard 0.25mum CMOS process with a memory access time of 20ns. Differential pair Flash cells with low programming current share the same bit-lines as SRAM cells within the same array. This enables row-to-row transfer of data between Flash and SRAM cells as well as access data through I/O directly, in return improving speed and lowering power. Area is saved through the shared usage of column decoding, sense-amplifier, and write-driver circuitry
Chemical Imaging of Interfaces by Sum Frequency Microscopy (1999)

We introduce a novel nonlinear optical microscope which provides interface specific, chemically and structurally resolved infrared information with the improved spatial resolution limit of a visible light microscope. High impact on the investigation of a large variety of interfaces is expected. Here, the microscope is applied in a dewetting study.
Diffraction properties of fixed gratings in photorefractive media (1990)

The diffraction properties of fixed volume gratings, including the effect of additional photorefractive energy coupling between the incident wave and the diffracted wave, are considered. Both transmission gratings and reflection gratings are treated. Analytical solutions for phase gratings are derived, and numerical solutions for absorption gratings are also obtained. The results are presented and discussed.
Meiotic recombination between two polymorphic restriction sites within the beta globin gene cluster. (1986)

Analysis of beta globin gene haplotypes for prenatal diagnosis of beta thalassaemia has revealed a recombination event within the beta globin gene cluster. Both a change in the AvaII polymorphic site within the beta globin gene and a change in the phenotype of the beta globin gene were observed. Paternity was established by the pedigree analysis of hypervariable 'minisatellite' DNA polymorphisms and the most probable explanation of the recombination event is a crossover between the psi beta globin gene and the beta globin gene. The data provide direct evidence in support of a DNA region 3' to the beta globin gene with a recombination frequency much higher than expected, and have important implications for the prenatal diagnosis of beta thalassaemia by linked restriction fragment length polymorphisms.
A review of iris recognition algorithms (2008)

Iris recognition has become a popular research in recent years. Due to its reliability and nearly perfect recognition rates, iris recognition is used in high security areas. Among its applications are border control in airports and harbors, access control in laboratories and factories, identification for Automatic Teller Machines (ATMs) and restricted access to police evidence rooms. This paper provides a review of major iris recognition researches. There are three main stages in iris recognition system: image preprocessing, feature extraction and template matching. A literature review of the most prominent algorithms implemented in each stage is presented.
Convenient Deuterium Labeling for Mass Spectrometry via Exchange of Enolizable Hydrogen on a Gas-Liquid Chromatography Column (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvenient Deuterium Labeling for Mass Spectrometry via Exchange of Enolizable Hydrogen on a Gas-Liquid Chromatography ColumnMartin Senn, Wilhelm J. Richter, and A. L. BurlingameCite this: J. Am. Chem. Soc. 1965, 87, 3, 680–681Publication Date (Print):February 1, 1965Publication History Published online1 May 2002Published inissue 1 February 1965https://pubs.acs.org/doi/10.1021/ja01081a069https://doi.org/10.1021/ja01081a069research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Data-driven. HHS unleashes wave of public health data so software developers can create tools to raise awareness, spur action. (2010)

Guided by how weather data from the National Oceanic and Atmospheric Administration fuels all kinds of weather reports, maps and forecasts, HHS officials saw parallels on how to distribute health data so software developers could create tools to be used by patients and providers. "We thought that was inspiring," said Todd Park, left, HHS' chief technology officer.
Reaction of 5-ethynyl-2'-deoxyuridylate with thiols and thymidylate synthetase (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of 5-ethynyl-2'-deoxyuridylate with thiols and thymidylate synthetasePhilip J. Barr, Morris J. Robins, and Daniel V. SantiCite this: Biochemistry 1983, 22, 7, 1696–1703Publication Date (Print):March 29, 1983Publication History Published online1 May 2002Published inissue 29 March 1983https://pubs.acs.org/doi/10.1021/bi00276a027https://doi.org/10.1021/bi00276a027research-articleACS PublicationsRequest reuse permissionsArticle Views125Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition (2015)

Cellular senescence is a widespread stress response and is widely considered to be an alternative cancer therapeutic goal. Unlike apoptosis, senescence is composed of a diverse set of subphenotypes, depending on which of its associated effector programs are engaged. Here we establish a simple and sensitive cell-based prosenescence screen with detailed validation assays. We characterize the screen using a focused tool compound kinase inhibitor library. We identify a series of compounds that induce different types of senescence, including a unique phenotype associated with irregularly shaped nuclei and the progressive accumulation of G1 tetraploidy in human diploid fibroblasts. Downstream analyses show that all of the compounds that induce tetraploid senescence inhibit Aurora kinase B (AURKB). AURKB is the catalytic component of the chromosome passenger complex, which is involved in correct chromosome alignment and segregation, the spindle assembly checkpoint, and cytokinesis. Although aberrant mitosis and senescence have been linked, a specific characterization of AURKB in the context of senescence is still required. This proof-of-principle study suggests that our protocol is capable of amplifying tetraploid senescence, which can be observed in only a small population of oncogenic RAS-induced senescence, and provides additional justification for AURKB as a cancer therapeutic target.
A monolithically integrated, intrinsically safe, 10% efficient, solar-driven water-splitting system based on active, stable earth-abundant electrocatalysts in conjunction with tandem III–V light absorbers protected by amorphous TiO<sub>2</sub> films (2015)

A monolithically integrated device, protected by a TiO<sub>2</sub> stabilization layer, splits water using sunlight.
Development of Sub-Quarter-µm MONOS (metal/oxide/nitride/oxide/semiconductor) Type Memory Transistor (1996)

A MONOS (metal/oxide/nitride/oxide/semiconductor) type nonvolatile memory transistor with a gate length of 0.23 µm has been developed. This memory transistor offers high endurance, low programming voltage and a narrow distribution of programmed threshold voltages. By introducing a rapid thermal nitridation (RTN) step into the fabrication prosecc of the ONO (oxide/nitride/oxide) layer, an enhancement in erase speed of one order of magnitude is achieved. The RTN also improves the oxidation resistance of the nitride layer, so that scaling down the thickness of the ONO film in order to reduce the programming voltage is feasible.
Membrane cofactor protein (MCP, CD46) in seminal plasma and on spermatozoa in normal and “sterile” subjects (1993)

A sperm protein of molecular mass 43 kDa (the spermatozoa membrane cofactor protein, smMCP) and a seminal plasma protein of 60 kDa (ssMCP) were identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) followed by immunoblotting with four monoclonal antibodies (mAb) against membrane cofactor protein (MCP, CD46). These proteins served as factor I cofactors for the cleavage of methylamine-treated C3 (C3ma), the activity of which was blocked by M75, an MCP cofactor-activity-blocking mAb. Thus, these semen proteins are antigenic and functional homologous of MCP. On SDS-PAGE analysis these MCP migrated as single-band proteins which differed from the two-band forms of MCP expressed on other cells. smMCP was N-glycosylated but not O-glycosylated, while ssMCP was O-glycosylated: after deglycosylation of these proteins bands were detected at 38-40 kDa and 43 kDa on SDS-PAGE, respectively. These semen MCP are therefore, structurally different from the conventional MCP. ssMCP in both normal and "sterile" subject groups was determined by sandwich enzyme-linked immunosorbent assay. Seminal plasma in the two groups contained 250-700 ng/ml ssMCP. The difference between the two groups was marginal, although samples from normal subjects tended to show higher concentrations of ssMCP than samples from "sterile" subjects. No molecular difference was observed with ssMCP and smMCP in the two groups by SDS-PAGE/immunoblotting analysis. Immunohistochemical analysis suggested that MCP was positive in glandular epithelial cells and the lumen of the prostate, and in most intra-lumen cells of the testis. Using antibody M177, solubilized prostate and testis were analyzed by immunoblotting and compared with other cell MCP. The major band of MCP in the testis, but not in the prostate, was of 60 kDa, which aligned with ssMCP. No band of testis or prostate MCP, however, aligned with smMCP. ssMCP may be produced in the testis, while the origin of smMCP remains unknown. We hypothesize that ssMCP is important in the survival of spermatozoa, protecting them against local secretion of immunoglobulin and complement in the female genital tract, and that smMCP, which is expressed on acrosome-reacted spermatozoa, plays an essential role in the interaction of spermatozoa with oocytes.
Tacrolimus treatment for infertility related to maternal‐fetal immune interactions (2019)

Many approaches have been used to achieve successful pregnancies in patients with infertility, though existing treatments remain unsatisfactory in patients with infertility caused by abnormal maternal-fetal immunity. However, our understanding of the immunological aspects of infertility has steadily progressed, aided by recent research into organ transplantation and cancer. The results of these recent analyses have led to the development and evaluation of several candidate immunological treatments, but the use of immunological treatments remains a novel approach. The current paper presents the hypothesis that tacrolimus may have potential as a candidate agent for the treatment of maternal-fetal immunity-related infertility.
Causal Attributions and Coronary Heart Disease in Women (1993)

The relationship between coronary heart-disease endpoints and attributional style in women has been previously unexamined. This study examined the attributions of 73 postmyocardial infarction (MI) women about their heart disease and explored the relationship between attributions and nonfatal coronary recurrence. Women's primary causal attributions included personal behavior (9.6%), blaming others (19.3%), stress (28.8%), luck (12.3%), and family history (13.7%). The largest proportion of recurrences occurred in women attributing their infarcts to marital problems. Of the attributional ratings, ascriptions involving spouses were the only attributions that met entry criteria for logistic regression (p = .019) after controlling for severity of first infarction.
<title>Geophysical Environmental Research Corporation 63-channel airborne imaging spectrometer and 12-band thermal scanner</title> (1990)

Two Geophysical Environmental Research Corp. (GER) scanners are discussed in this paper. The GER 63 channel airborne imaging spectrometer covers 0.4-2.5 micrometer. There are 24 channels from 500-1000 nm, 7 channels from 1-1.8 micrometer and 32 channels from 2-2.5 micrometer. The thermal scanner has one channel in 0.4-1.1 micrometer, one channel in 3-5 micrometer, 3 channels with 1 micrometer bandwidth in 8-12 micrometer, 6 channels with half micrometer bandwidth in 8-12 micrometer and one channel in 8-12 micrometer. The GER thermal scanner was first flown in January 1990. The initial results indicate that this type of scanner gives the lowest noise equivalent temperature available.
Muscular dystrophy due to dysferlin deficiency in Libyan Jews (2000)

The cluster in Jews of Libyan origin of limb-girdle muscular dystrophy type 2B due to a dysferlin 1624delG mutation is described. The carrier frequency of this mutation is calculated to be approximately 10% in this population, in which the disease prevalence is at least 1 per 1300 adults. Twenty-nine patients from 12 families were all homozygous for the same mutation. However, clinical features were heterogeneous even within the same family: in half of the patients onset was in the distal muscles of the legs, which is similar to Miyoshi myopathy, while in others onset was in the proximal musculature, which is similar to other forms of limb-girdle dystrophies. Age at onset varied from 12 to 28 years (mean 20.3 +/- 5.5 years). One patient was presymptomatic at age 28 years. Progression was slow regardless of age of onset, patients remaining ambulatory until at least 33 years. Five patients described subacute, painful enlarged calves as an early, unusual feature. The variable features in this ethnic cluster contribute to the definition of the clinical spectrum of dysferlinopathies in general. The cause of the observed heterogeneity remains unclear.
Business Continuity Strategies: Protecting Against Unplanned Disasters (2006)

About the Author. Preface. 1 Defining the Problem. Business Continuity Concerns. Characteristics of a Sound Program. Cost-Reduction Opportunities. Need for Cost-Effective Solutions. Backup. 2 Workplace Violence. Background. Liability. Prevention. Incident Response. 3 Final Reports of the Federal Building and Fire Investigation of the World Trade Center Disaster. Introduction. Increased Structural Integrity. Enhanced Fire Endurance of Structures. New Methods for Fire-Resistant Design of Structures. Improved Active Fire Protection. Improved Building Evacuation. Improved Emergency Response. Improved Procedures and Practices. Education and Training. Looking Forward. 4 New Contingency Program Paradigm. Background. Old Paradigm. New Paradigm. Transitioning to the New Paradigm. 5 Developing a Contingency Program. Management's Responsibility. How Much Market Share Could Cost You? Protect Against What? Contingency Planning Requires Specialization. Increased Technology Dependency. Corporate Issue. Contingency Program Phases. Discretionary Expense. Project Planning. Awareness Education. Business Impact Analysis. Selecting a Methodology. Implementation. Maintenance and Testing. 6 Guidelines for Developing Contingency Programs at Multiple Locations. Background. Objectives and Scope. Section I: Organization. Section II: Standards for Implementation Planning. Section III: Standards for Developing Interim Processing Strategies. Section IV: Documentation Standards. Section V: Standards for Ongoing Maintenance and Testing. 7 Conceptual Business Continuity Strategies for Loss of Computer Operations. Policy and Strategy. Executive Summary. Glossary. Index.
Extremely nondegenerate two-photon absorption in direct-gap semiconductors [Invited] (2011)

Two-photon absorption (2PA) spectra with pairs of extremely nondegenerate photons are measured in several direct-gap semiconductors (GaAs, CdTe, ZnO, ZnS and ZnSe) using picosecond or femtosecond pulses. In ZnSe, using photons with a ratio of energies of ~12, we obtain a 270-fold enhancement of 2PA when comparing to the corresponding degenerate 2PA coefficient at the average photon energy (ηω1 + ηω2)/2. This corresponds to a pump photon energy of 8% of the bandgap. 2PA coefficients as large as 1 cm/MW are measured. Thus, by using two widely different wavelengths we are able to access the large 2PA observed previously only in narrow gap semiconductors. We also calculate the corresponding enhancement of nonlinear refraction, consisting of two-photon, AC-Stark and Raman contributions. The net effect is a smaller enhancement, but exhibits very large dispersion within the 2PA regime.