gebhart/patrepeval huggingface dataset:
Transformed cells exhibit altered response to db cycle amp-mediated modulation of protein phosphorylation and different endogenous phosphoprotein acceptors. (1981)

Endogenous protein phosphorylation has been studied in extracts from rat cells transformed by temperature-sensitive derivatives of Rous sarcoma virus which can reversibly express a transformed behavior at 33 degrees C and reacquire "normal" properties at 39 degrees C. The expression of transformation appeared associated with marked alterations in the type of phosphoprotein acceptors and with an increased protein kinase activity, particularly in detergent solubilized fractions. A comparison of the effect of dibutyryl cyclic AMP on protein phosphorylation revealed a transformation-dependent response, as well as a different effect of the cycle nucleotide in cytoplasmic and detergent solubilized fractions. Our studies suggest that the processes leading to malignant transformation are accompanied by altered response of the phosphorylating system to cyclic nucleotide-mediated modulation and by marked alteration in phosphoprotein acceptors.
Continuous assessment of a Unix configuration: integrating intrusion detection and configuration analysis (2002)

Computer security is a topic of growing concern because, on the one hand, the power of computers continues to increase at exponential speed and all computers are virtually connected to each other and because, on the other hand, the lack of reliability of software systems may cause dramatic and unrecoverable damage to computer systems and hence to the newly emerging computerized society. Among the possible approaches to improve the current situation, expert systems have been advocated to be an important one. Typical tasks that such expert systems attempt to achieve include finding system vulnerabilities and detecting malicious behaviour of users. We extend our intrusion detection system ASAX with a deductive subsystem that allows us to assess the security level of a software configuration on a real time basis. By coupling the two subsystems-intrusion detection and configuration analysis-we moreover achieve a better tuning of the intrusion detection since the system has only to enable intrusion detection rules that are specifically required by the current state of the configuration. We also report some preliminary performance measurements, which suggest that our approach can be practical in real life contexts.
Osmolytes stimulate the reconstitution of functional 50S ribosomes from in vitro transcripts of Escherichia coli 23S rRNA (2002)

Functional Escherichia coli 50S ribosomal subunits can be reconstituted from their natural rRNA and protein components. However, when the assembly is performed with in vitro-transcribed 23S rRNA, the reconstitution efficiency is diminished by four orders of magnitude. We tested a variety of chemical chaperones (compounds that are typically used for protein folding), putative RNA chaperones (proteins) and ribosome-targeted antibiotics (small-molecule ligands) that might be reasoned to aid in folding and assembly. Addition of the osmolyte trimethylamine-oxide (TMAO) and the ketolide antibiotic telithromycin (HMR3647) to the reconstitution stimulates its efficiency up to 100-fold yielding a substantially improved system for the in vitro analysis of mutant ribosomes.
Modified Ritz Method (1934)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults (2017)

In contrast with prevailing recommendations, OH measurements performed within 1 minute of standing were the most strongly related to dizziness and individual adverse outcomes, suggesting that OH be assessed within 1 minute of standing.
Power 모형을 이용한 비정상성 확률강수량 산정 (2014)

In this study, we performed a non-stationary frequency analysis using a power model and the model was applied for Seoul, Daegu, Daejeon, Mokpo sites in Korea to estimate the probable precipitation amount at the target years (2020, 2050, 2080). We used the annual maximum precipitation of 24 hours duration of precipitation using data from 1973 to 2009. We compared results to that of nonstationary analyses using the linear and logistic regression. The probable precipitation amounts using linear regression showed very large increase in the long term projection, while the logistic regression resulted in similar amounts for different target years because the logistic function converges before 2020. But the probable precipitation amount for the target years using a power model showed reasonable results suggesting that power model be able to reflect the increase of hydrologic extremes reasonably well.
Identification of a putative tumor marker in breast and colon cancer. (1993)

Application of a recently developed phospholipid saponification procedure to malignant colon or breast tissue produces an unidentified phosphodiester resonance in the 31P nuclear magnetic resonance spectrum which appears to correlate with malignancy. Glycerol phosphodiesters were prepared from a malignant breast tumor by a Folch extraction of the tissue followed by saponification of the resulting phospholipids. These compounds were separated by ion exchange chromatography and the compound responsible for this new resonance was isolated and identified as glycerol 2-phosphoglycerol by high resolution nuclear magnetic resonance spectroscopy. Confirmation of this structure was achieved by chemical synthesis of glycerol 2-phosphoglycerol. Attempts to isolate the phospholipid responsible for this resonance showed that it is not derived from a new class of phospholipids but is most likely an artifact of the new saponification procedure used. Glycerol 2-phosphoglycerol is formed via glycerol 2,3-(cyclic) phosphate derived from phosphatidylcholine followed by reaction with glycerol. Malignant tissue is more prone to produce this compound than is nonmalignant tissue and the differences between these tissue types may be a form of phosphatidylcholine that is present in higher concentrations in malignant tumor membranes than in those of normal tissue.
George and Djuruna (1950)

George and Djuruna, Nangiljuna, Admiral, spearing crocodile at Bussilimba? Crocs on shallow water amongst rocks.
Monotherapy Trials of New Antiepileptic Drugs (1997)

A number of clinical trials that test the efficacy and safety of the newer antiepileptic drugs (AEDs) have recently been concluded. Two dose-response trials in inpatients with refractory partial seizures and outpatients with newly diagnosed partial epilepsy established the efficacy of gabapentin as monotherapy. Lamotrigine was found to have efficacy similar to that of phenytoin and carbamazepine (CBZ) and to be better tolerated than CBZ in patients with newly diagnosed epilepsy. It was also shown to have efficacy as monotherapy in partial seizures, based on the results of an active controlled trial, and in the treatment of absence seizures, based on the results of a responder-enriched study. Topiramate as monotherapy was found to be efficacious for treatment of partial-onset seizures, based on the results of a single-center dose-response trial. A dose-response trial that tested the efficacy of tiagabine monotherapy in patients with refractory partial epilepsy was uninformative. Oxcarbazepine was found to be safe and efficacious in four comparative trials in patients with newly diagnosed epilepsy as well as in one placebo-controlled inpatient trial in patients with refractory partial seizures.
A purely ultracapacitor energy storage system for hybrid electric vehicles utilizing a microcontroller-based DC-DC boost converter (2004)

The design and testing of a purely ultracapacitor energy storage system for the improvement of hybrid electric vehicles is presented. The system utilizes two large ultracapacitor banks for energy storage and a dc-dc boost converter that is capable of supplying 8 kW for voltage regulation. The system provides greater roundtrip efficiency over batteries, improves a vehicle's ability to recapture energy from regenerative braking, and is controlled and protected by a microcontroller. The paper presents design considerations, simulation, and hardware results of the system.
Availability performance comparisons of combined Loran-C/GPS and standalone GPS approach navigation systems (2002)

Operational air navigation systems not only must provide adequate position estimates, but they also must be available to the user when needed, and able to warn the user in a timely manner when the system becomes unusable. The paper addresses the availability of a combination Loran-C and GPS radionavigation system during nonprecision approach (NPA). Also, GPS by itself cannot meet the sole means integrity requirements for NPA. Simulation models were developed to quantify statistically the availability of the Loran-C/GPS system and to compare it with GPS alone. The results presented in the paper show that the combination Loran-C/GPS navigation system enhances the availability of either standalone system by at least a factor of ten. Loran-C also enhances the integrity of GPS. Loran-C can use the same approach geometry and cockpit display instruments now allowed for GPS.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Convex Decomposition of Simple Polygons (1984)

An algorithm is described for the decomposition of a bounded concave region of E2 space into a settheoretic combination of convex regions. This algorithm finds the convex hull of the region and then recurses to find the convex hulls of the difference between the original region and its convex hull, until such regions are convex. It exhibits a linear-time complexity for regions whose difference with their convex hull consists of only convex inner regions, a quadratic worst-case complexity, and an average complexity a little worse than linear.
A matrix-multiply unit for posits in reconfigurable logic leveraging (open)CAPI (2018)

In this paper, we present the design in reconfigurable logic of a matrix multiplier for matrices of 32-bit posit numbers with es=2 [1]. Vector dot products are computed without intermediate rounding as suggested by the proposed posit standard to maximally retain precision. An initial implementation targets the CAPI 1.0 interface on the POWER8 processor and achieves about 10Gpops (Giga posit operations per second). Follow-on implementations targeting CAPI 2.0 and OpenCAPI 3.0 on POWER9 are expected to achieve up to 64Gpops. Our design is available under a permissive open source license at https://github.com/ChenJianyunp/Unum_matrix_multiplier. We hope the current work, which works on CAPI 1.0, along with future community contributions, will help enable a more extensive exploration of this proposed new format.
Advances in approximate Bayesian computation with modified pseudo-likelihood roots (2013)

The likelihood function plays a central role in the theory of\nhigher-order asymptotics both for Bayesian and frequentist inference. This theory provides accurate\napproximations to posterior distributions and to related quantities, even for small sample sizes.\nMoreover, these approximations give rise to a simple simulation\nscheme, alternative to MCMC, for Bayesian computation of marginal\nposterior distributions for a scalar parameter.\\\\\nHowever, in complex models or in the presence of minimal\nassumptions on the model, the likelihood function may be unfeasible and\npseudo-likelihood functions (such as the composite, the empirical, the\nquasi- and the partial likelihood) may be used as a basis\nfor Bayesian inference. This paper aims to discuss higher-order\nasymptotics for Bayesian computation of pseudo-posterior distributions,\ne.g. posterior distributions based on suitable pseudo-likelihood\nfunctions, and to the corresponding tail area probabilities, for practical\nuse in Bayesian analysis. The method is illustrated by two examples.
An investigation of the antigenic structure of <i>Toxoplasma gondii</i> (1981)

Mechanical fragmentation has been the prime method for preparing soluble Toxoplasma gondii antigens for use in serodiagnosis. The three methods most commonly used (lysis-in-water, sonication and freeze-thawing) all yielded three antigenic peaks (4, 5 and 6) on crossed immunoelectrophoresis. Antigen 6 has been shown to be heat stable (56 degrees C/1 h) and appears to be a major antigen in the indirect haemagglutination test (IHAT). Saponin and octyl glucoside were found to be the most effective detergents for solubilization when used in combination, yielding between 7 and 11 antigens. Using a new triple-staining technique, antigen 3 has been characterized as a glycoprotein, antigen 7 as a lipopolysacchiaride and antigens 1, 2, 4, 5, 6 and 8 to 11 as proteins. Molecular weight determination by gel filtration has been carried out and the majority of the antigens have a mol. wt of 10(5) to 1.5 x 10(5) daltons. Crossed immunoelectrofocusing has shown that all the antigens are isoelectric at acidic pH. The findings of this preliminary investigation into the basic antigenic structure of T. gondii are discussed in relation to future work and the rational development of serodiagnostic tests.
Laser-assisted three-dimensional rotation of microscopic objects (2004)

We describe an approach for laser-assisted three-dimensional rotation of microscopic objects that is rather simple to implement. In our approach a tangential force is applied on the object to cause its rotation by focusing a pulsed near infrared laser beam at a point on the periphery of the object. Rotation of a leaf tissue section in three dimensions about various axes including those orthogonal to the beam propagation axis could be demonstrated using this approach. Further, with this approach an optically trapped dividing chloroplast could be oriented to permit imaging from different angles of view.
The Key Word Is Survival (1978)

Inspired by Gilbert Weldy's article "The Busy Principal Syn drome" (NASSP Bulletin, December 1977), this author offers his own tongue-in-cheek advice on how to survive the princi palship.
Effect of extraction temperature on cream and extractability of black tea [<i>Camellia sinensis</i> (L.) O. Kuntze] (2003)

Abstract Tea cream and haze in black tea infusions increased with the rise in the tea extraction temperature. The temperature at which substances involved in cream and haze formation began to be extensively extracted into the tea infusion was between 50 and 60 °C. The tea cream particle volume concentration in infusions extracted at 50 °C or below formed less tea cream particles, and their particle sizes were larger and more heterogeneous than those extracted at 60 °C and second infusions extracted at 90 °C from the residual leaves that were previously extracted at 40–50 °C. High-performance liquid chromatography confirmed that constituents with pyrogallol groups are involved in tea creaming, and the effect of caffeine on tea cream and haze depends on whether these constituents are sufficiently present. The extractability of tea increased with the rise in extraction temperature. Two-stage extraction of tea in ready-to-drink tea processing and its effects on colorimetric indicators were also examined.
Telomere length in early life predicts lifespan (2012)

The attrition of telomeres, the ends of eukaryote chromosomes, is thought to play an important role in cell deterioration with advancing age. The observed variation in telomere length among individuals of the same age is therefore thought to be related to variation in potential longevity. Studies of this relationship are hampered by the time scale over which individuals need to be followed, particularly in long-lived species where lifespan variation is greatest. So far, data are based either on simple comparisons of telomere length among different age classes or on individuals whose telomere length is measured at most twice and whose subsequent survival is monitored for only a short proportion of the typical lifespan. Both approaches are subject to bias. Key studies, in which telomere length is tracked from early in life, and actual lifespan recorded, have been lacking. We measured telomere length in zebra finches (n = 99) from the nestling stage and at various points thereafter, and recorded their natural lifespan (which varied from less than 1 to almost 9 y). We found telomere length at 25 d to be a very strong predictor of realized lifespan (P < 0.001); those individuals living longest had relatively long telomeres at all points at which they were measured. Reproduction increased adult telomere loss, but this effect appeared transient and did not influence survival. Our results provide the strongest evidence available of the relationship between telomere length and lifespan and emphasize the importance of understanding factors that determine early life telomere length.
Corneal reepithelialization and anti-inflammatory agents. (1982)

These studies have demonstrated that nonsteroidal anti-inflammatory agents (cyclooxygenase and lipoxygenase inhibitors) can inhibit PMN arrival in the tear fluid following corneal injury but do not inhibit the reepithelialization either by corneal epithelial cells or by conjunctival epithelial cells. Therefore, they can be used safely in ocular inflammatory conditions even when corneal epithelial defects are present. Corticosteroids, on the other hand, inhibit reepithelialization by conjunctival epithelial cells and not by corneal epithelial cells in the doses tested. This inhibition does not occur with pretreatment prior to injury, suggesting that corticosteroids can be used clinically in conditions that have intact corneal epithelium without fear of slowing down wound healing should epithelial defects occur when not on steroid therapy. Furthermore, the steroid inhibition is temporary since there is a breakthrough in steroid inhibition with time, and occurs only if the steroids have been used shortly after deepithelialization. The steroid inhibition can be reversed by specific steroid antagonist, indicating that the steroid effect is mediated through specific receptors. An exciting and new hypothesis proposes that corticosteroids induce the formation of an inhibitory protein that inhibits the phospholipase enzyme to cause a block in arachidonic acid release from cell membranes. This mechanism of action may also be prevalent in the steroid effect on corneal reepithelialization, and experiments are under way to isolate this inhibitory protein from steroid-treated conjunctival epithelium. This isolation and pharmacologic characterization of this inhibitory protein is of obvious advantage to the field of ophthalmic therapeutics since this protein may have the anti-inflammatory potential of the steroids without their steroid sideeffects.
Cholesteric polarisers: simulated performance in PLLCDs (1998)

Abstract In order to assess the performance limitations of cholesteric polarisers in photoluminescent liquid crystal displays, we have calculated their optical characteristics using a 4×4 matrix formalism combined with the concept of integrated transmission. Fixed‐pitch polarisers are considered under controlled illumination conditions. High extinction and transmission can be achieved using narrow‐band low‐divergence illumination.
Interferon-β Treatment Eliminates Cardiotropic Viruses and Improves Left Ventricular Function in Patients With Myocardial Persistence of Viral Genomes and Left Ventricular Dysfunction (2003)

A 6 months, IFN-beta treatment was safe in patients with myocardial enteroviral or adenoviral persistence and LV dysfunction and resulted in elimination of viral genomes (22 of 22 patients) and improved LV function (15 of 22 patients).
Metal(II) <i>d</i>-Tartrates Catalyzed Asymmetric Ring Opening of Oxiranes with Various Nucleophiles (1988)

Abstract The asymmetric ring opening of meso-2,3-disubstituted oxiranes with thiols, aniline, and trimethylsilyl azide was studied by the use of metal(II) d-tartrates as heterogeneous chiral Lewis acid catalysts. The enantioselectivity varied widely with the combination of oxirane, nucleophile, and metal(II) d-tartrate, and Zn(II) d-tartrate gave the best enantioselectivity in the respective reactions of 1,2-epoxycyclohexane with 1-butanethiol, aniline, and trimethylsilyl azide to afford the corresponding adducts in 85, 58, and 42% ee, respectively. Furthermore, the kinetic resolution of racemic oxiranes with thiols catalyzed by Zn(II) d-tartrate was studied.
Femtosecond Ultraviolet Pulse Generation in β-BaB 2 O 4 (1988)

Almost all current results on ultrafast processes are derived from femtosecond lasers in the visible or near infrared. There is a clear need to extend the wavelength range of high repetition rate femtosecond pulses into the ultraviolet (uv). Frequency doubling (SHG), both extra1- and intracavity2, represents one technique for generating such pulses. However, the results achieved so far have been far short of what have been achieved in the visible. In this talk, we report an intracavity doubling experiment using the new nonlinear optical crystal β-BaB2O4 (BBO) that results in nearly complete recovery of the normal visible fundamental output power in the form of femtosecond uv pulses at the second harmonic. Recent success in our laboratory in growing and fabricating high quality BBO crystals3 has enabled us to generate the shortest uv pulses reported so far, less than 45 fs at 315 nm.
Relative Mass Defect Filtering of High-Resolution Mass Spectra for Exploring Minor Selenium Volatiles in Selenium-Enriched Green Onions (2006)

In this study, the presence of minor Se-containing volatiles in Se-enriched green onions (Allium fistulosum) was investigated using the combination of high-resolution mass spectrometry, inductively coupled plasma mass spectrometry, and a simple relative mass defect-based algorithm to aid trace level analysis of unknown components. This confirmed the structures of volatiles reported previously, along with several unreported small molecular weight Se-containing volatiles from plants, such as MeSeSeSMe. This data analysis technique was also useful to link the results obtained from molecular and elemental mass spectrometry thus aiding in the search for new trace level Se-containing volatiles.