gebhart/patrepeval huggingface dataset:
Cue integration for the perception and control of self-movement in ageing and Alzheimer's disease (2006)

The perception and control of self-movement relies on visual cues derived from the radial patterns of optic flow and from the relative motion of objects within view. Optic flow and object motion processing impairments might limit independent self-movement in a manner like that seen in ageing and in Alzheimer's disease. We used optic flow and object motion stimuli to simulate aspects of the self-movement scene. Stimulus salience was individualized to present comparable stimuli to young [n = 18; mean age = 25.6, standard error of measurement (SEM) = 1.4], middle-aged (n = 17; mean age = 53.9, SEM = 0.9), older adult (n = 30; mean age = 72.4, SEM = 1.4) and Alzheimer's disease (n = 15; mean age 75.2, SEM = 1.6) subjects. All groups were tested in two tasks: pointing towards the simulated direction of self-movement and steering the simulated self-movement towards a straight-ahead direction. We found that young and middle-aged subjects show similar pointing accuracy using either optic flow or object motion, but steer better with object motion than with optic flow. Older adult subjects show better performance with optic flow than object cues for pointing (P < 0.001), but their performance improves when both cues are combined in the pointing (P = 0.012) and steering (P = 0.02) tasks. Alzheimer's disease patients show poorer performance with optic flow and object motion than all other groups and do not benefit from the combined presentation of cues for either pointing or steering. We conclude that ageing and Alzheimer's disease are associated with distinct profiles of visual processing deficits that limit the ability to use optic flow and object motion to perceive and control self-movement.
Breast cancer breakthroughs (2002)

Explore innovative breast cancer initiatives, including ductal lavage, digital mammography, sentinel lymph node biopsy, chemoprevention, radiation therapy, hormonal therapies, and targeted therapies.
Improving geometric accuracy in the presence of susceptibility difference artifacts produced by metallic implants in magnetic resonance imaging (2005)

Geometric and intensity distortions due to the presence of metallic implants in magnetic resonance imaging impede the full exploitation of this advanced imaging modality. The aim of this study is to provide a method for (a) quantifying and (b) reducing the implant distortions in patient images. Initially, a set of reference images (without distortion) was obtained by imaging a custom-designed three-dimensional grid phantom. Corresponding test images (containing the distortion) were acquired with the same imaging parameters, after positioning a specific metallic implant in the grid phantom. After determining: 1) the nonrecoverable; 2) the distorted, but recoverable; and 3) the unaffected areas, a point-based thin-plate spline image registration algorithm was employed to align the reference and test images. The calculated transformation functions utilized to align the image pairs described the implant distortions and could therefore be used to correct any other images containing the same distortions. The results demonstrate successful correction of grid phantom images with a metallic implant. Furthermore, the calculated correction was applied to porcine thigh images bearing the same metallic implant, simulating a patient environment. Qualitative and quantitative assessments of the proposed correction method are included.
American Journal of Diseases of Children: volume 8, No. 6, December, 1914, Pages 399-405 (2009)

Infantile Scurvy: The Blood, the Blood-Vessels and the Diet Alfred F. Hess, M.D., Alfred F. Hess, M.D. New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Mildred Fish Mildred Fish New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Nutrition Reviews, Volume 35, Issue 1, January 1977, Pages 12–14, https://doi.org/10.1111/j.1753-4887.1977.tb06479.x Published: 01 January 1977
Gas‐phase polymerization of propylene with a highly active ziegler‐natta catalyst (1999)

Abstract The polymerization of propylene in the gas phase has been studied with the same high‐activity catalyst as was used for liquid‐phase polymerizations in earlier work. Catalyst injection, the influence of the support bed, and precontacting of the catalyst with the cocatalyst and the electron donor have been investigated. Furthermore, different ways of prepolymerization were tested. The kinetics can be described with the same model as was used for the liquid‐phase polymerizations. The reaction rate was proportional to the pressure at pressures above 5 bar; at lower pressures the rates are lower. Comparison of the reaction rates in the gas phase and liquid phase showed the rates in the gas phase were still lower than in the liquid phase. The fast decay observed in the gas‐phase polymerizations indicated that thermal runaway and deactivation may occur at temperatures above 40–45°C.
A compact representation for file versions: a preliminary report (2003)

A system is presented for the compact representation of multiple versions of a file. The presentation is in terms of vectors and matrices, which results in conceptual simplicity. Algebraic transformations enable the retrieval process to be optimized for any given version or set of versions, in contrast to always optimizing for the most recent or least recent version. Moreover, any version can be added or deleted without affecting any other. File differencing and dictionary compaction are unified, and data compression can be included. A compact representation for the (sparse) matrices is presented, and the main algorithms are described in terms of this representation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Biomedical applications of diamond‐like carbon coatings: A review (2007)

Owing to its superior tribological and mechanical properties with corrosion resistance, biocompatibility, and hemocompatibility, diamond-like carbon (DLC) has emerged as a promising material for biomedical applications. DLC films with various atomic bond structures and compositions are finding places in orthopedic, cardiovascular, and dental applications. Cells grew on to DLC coating without any cytotoxity and inflammation. DLC coatings in orthopedic applications reduced wear, corrosion, and debris formation. DLC coating also reduced thrombogenicity by minimizing the platelet adhesion and activation. However, some contradictory results (Airoldi et al., Am J Cardiol 2004;93:474-477, Taeger et al., Mat-wiss u Werkstofftech 2003;34:1094-1100) were also reported that no significant improvement was observed in the performance of DLC-coated stainless stent or DLC-coated femoral head. This controversy should be discussed based on the detailed information of the coating such as atomic bond structure, composition, and/or electronic structure. In addition, instability of the DLC coating caused by its high level of residual stress and poor adhesion in aqueous environment should be carefully considered. Further in vitro and in vivo studies are thus required to confirm its use for medical devices.
Kernel performance in meeting hard real-time system characteristics (the ARTOS real-time kernel) (1996)

\n\t\t\t\t\tDescribes the design and implementation of an operating system kernel specifically designed to support real-time applications. It emphasises portability and aims to support state-of-the-art concepts in real-time programming. Discusses architectural aspects of the ARTOS kernel, and introduces new concepts on the areas of interrupt processing, scheduling, mutual exclusion and inter-task communication. Also explains the programming environment of ARTOS kernal and its task model, defines the real-time task states and system data structures and discusses exception handling mechanisms which are used to detect missed deadlines and take corrective action.\n\t\t\t\t
Antibody response to cytomegalovirus polypeptides captured by monoclonal antibodies on the solid phase in enzyme immunoassays (1985)

Antibodies to different cytomegalovirus (CMV) polypeptide antigens, captured by monoclonal antibodies coated on the solid phase of an enzyme immunoassay test, were analyzed in 42 serum pairs submitted for serodiagnosis of CMV infection. Three CMV antigens, captured on the solid phase by three monoclonal antibodies of different specificities, designated CH92-1, CH65-1, and CH16-1, were glycoproteins A (gA), gC, and gD, respectively; and one antigen, captured by CH23, was a polypeptide with an apparent molecular weight of 150,000, possibly associated with the nucleocapsid. Of these four CMV antigens, gA captured by CH92-1 was most effective in eliciting an antibody response. Antibody to this antigen was present in serum samples at a higher concentration in primary and reactivated infection and persisted longer than did antibody to the other tested antigens. In contrast, antibody to antigen captured by CH23 was at a lower concentration, rose more slowly in infection, and persisted for a shorter time than did antibody to the other antigens. Antibody response to gC and gD was intermediate in concentration and temporal appearance compared with the antibody response to gA and to the polypeptide bound by CH23. An enzyme immunoassay on paired serum samples with the captured glycoproteins as antigen was equal for the detection of current infection to an enzyme immunoassay with the whole CMV antigen from infected cell lysates. Enzyme immunoassays with either the CMV glycoproteins or the whole CMV antigen from infected cell lysates were superior to a complement fixation test with a glycine extract antigen for serodiagnosis of current infection.
A Mini-intronic Plasmid (MIP): A Novel Robust Transgene Expression Vector In Vivo and In Vitro (2013)

The bacterial backbone (BB) sequences contained within a canonical plasmid DNA dampen exogenous transgene expression by tenfold to 1,000-fold over a period of a few weeks following transfection into quiescent tissues such as the liver. Minicircle DNA vectors devoid of bacterial plasmid backbone sequences overcome transgene silencing providing persistent transgene expression. Because, we recently established that the length rather than sequence of the DNA flanking the transgene expression cassette is the major parameter affecting transgene silencing, we developed an alternative plasmid propagation process in which the essential bacterial elements for plasmid replication and selection are placed within an engineered intron contained within the eukaryotic expression cassette. As with the minicircle vector, the mini-intronic plasmid (MIP) vector system overcomes transgene silencing observed with plasmids but in addition provides between 2 and often 10 times or higher levels of transgene expression compared with minicircle vectors containing the same expression cassette in vivo and in vitro. These improved plasmids will benefit all studies involving gene transfer/therapy approaches.
The effect of subunit or modified live bovine herpesvirus-1 vaccines on the efficacy of a recombinant Pasteurella haemolytica vaccine for the prevention of respiratory disease in feedlot calves. (1992)

The efficacy of a Pasteurella haemolytica vaccine (PhV) administered once to calves within 24 hours of arrival at a feedlot was tested for the ability to prevent morbidity and mortality from all bovine respiratory disease (BRD) and specifically from fibrinous pneumonia mortality. The PhV consisted of two immunizing ingredients: outer membrane proteins extracted from P. haemolytica, plus genetically attenuated leukotoxin produced by recombinant DNA technology. This double blind study was conducted at a large Saskatchewan feedlot using 2,324 high-risk calves purchased at auction markets and kept under typical commercial feedlot conditions. The trial design included four vaccine test groups: 1) PhV and a bovine herpesvirus type-1 (BHV-1) subunit vaccine comprised only of the virus glycoprotein IV (gIV); 2) PhV and a commercial modified live vaccine (MLV) containing BHV-1 and parainfluenza-3 viruses; 3) gIV alone; and 4) MLV alone. Calves were assigned to vaccine groups in a random systematic manner, individually identified, and monitored for 90 days after vaccination. The vaccines were given once, on arrival, to reflect common feedlot practice, although vaccination prior to expected risk would be more appropriate.The PhV in combination with gIV reduced BRD morbidity by 20% (p < 0.05) compared to gIV alone and 24% (p < 0.05) compared to MLV alone, and reduced BRD mortality by 88% (p < 0.05) and fibrinous pneumonia mortality by 100% (p < 0.05) when compared to either gIV or MLV alone. Vaccination with PhV in combination with MLV significantly reduced the efficacy of the PhV in preventing BRD morbidity, BRD mortality, and fibrinous pneumonia mortality and also reduced the antibody response to P. haemolytica leukotoxin. These results suggest that the MLV interfered with the protective capacity of the PhV.
Immunogenicity of an Escherichia coli (Serotype O1) Pili Vaccine in Chickens (1985)

Immunogenicity of an oil-emulsified Escherichia coli (serotype O1) pili vaccine was evaluated in chickens. Chickens were vaccinated with 116 micrograms or 29 micrograms of pili protein and challenged with the homologous E. coli via the posterior thoracic air sac. Unvaccinated chickens were challenged to serve as positive controls or left unchallenged to serve as negative controls. Vaccinated chickens were protected against challenge because they suffered low or no mortality; had mild gross lesions in air sacs, pericardial sacs, and livers, and the scored values were significantly (P less than or equal to 0.05) lower than those in the positive controls; and eliminated E. coli from tissues more efficiently than the positive controls.
California's experience with low MS‐AFP results (1988)

The California AFP Screening Program was developed to offer pregnant women the opportunity to have their pregnancies screened for open neural tube defects (NTD). Because it is unwise to withhold potentially important clinical information about low MS-AFP results from the screened women and their physicians, follow-up diagnostic evaluations and counseling were offered to women with low MS-AFP results in addition to those with high results or positive family histories of NTD. Between April 7, 1986 and September 30, 1987, over 275,000 women voluntarily participated in the screening program. During the first year of the program 3,939 women were seen for follow-up evaluations due to low MS-AFP results. These evaluations occurred at state-approved AFP follow-up centers where ultrasonographic dating led to reinterpretation of 35% of the results. Of the remaining 2,552 (65%), 1,940 women (76%) had an amniocentesis. Sixteen Down syndrome fetuses were detected for a yield of 1/121 amniocenteses. Additional chromosome abnormalities included trisomies 18 and 13, Ullrich-Turner syndrome, (45,X), Klinefelter syndrome (47,XXY) and triploidy. The total yield of significant chromosome abnormalities was 1/78 amniocenteses.
ACID/HNN: clustering hierarchies of neural networks for context-dependent connectionist acoustic modeling (2002)

We present the ACID/HNN framework, a principled approach to hierarchical connectionist acoustic modeling in large vocabulary conversational speech recognition (LVCSR). Our approach consists of an agglomerative clustering algorithm based on information divergence (ACID) to automatically design and robustly estimate hierarchies of neural networks (HNN) for arbitrarily large sets of context-dependent decision tree clustered HMM states. We argue that a hierarchical approach is crucial in applying locally discriminative connectionist models to the typically very large state spaces observed in LVCSR systems. We evaluate the ACID/HNN framework on the Switchboard conversational telephone speech corpus. Furthermore, we focus on the benefits of the proposed connectionist acoustic model, namely exploiting the hierarchical structure for speaker adaptation and decoding speed-up algorithms.
Field trial of Tiramisu (2011)

Crowd-sourcing social computing systems represent a new material for HCI designers. However, these systems are difficult to work with and to prototype, because they require a critical mass of participants to investigate social behavior. Service design is an emerging research area that focuses on how customers co-produce the services that they use, and thus it appears to be a great domain to apply this new material. To investigate this relationship, we developed Tiramisu, a transit information system where commuters share GPS traces and submit problem reports. Tiramisu processes incoming traces and generates real-time arrival time predictions for buses. We conducted a field trial with 28 participants. In this paper we report on the results and reflect on the use of field trials to evaluate crowd-sourcing prototypes and on how crowd sourcing can generate co-production between citizens and public services.
Expedited Access to Vinaxanthone and Chemically Edited Derivatives Possessing Neuronal Regenerative Effects through Ynone Coupling Reactions (2015)

The natural product vinaxanthone has demonstrated a remarkable capability to promote nerve growth following injury or transplantation. In rats following total transection of the spinal cord delivery of vinaxanthone enhanced axonal regeneration, remyelination and angiogenesis at the site of injury all leading to an improved reinstatement of motor function. Through the development of a new ynone coupling reaction, chemically edited derivatives of vinaxanthone have been prepared and studied for improved activity. The coupling reaction allows rapid access to new derivatives, wherein n ynone precursors provide n(2) vinaxanthone analogues. These compounds have been tested for their ability to promote neuronal regrowth using laser axotomy, severing axonal connections in Caenorhabditis elegans. This precise microsurgery using C. elegans allows a new in vivo approach for medicinal chemistry based optimization of neuronal growth promoting compounds.
Immunotherapy in gram-negative bacterial infections. (1995)

Endotoxins are responsible for initiation of septic shock which increases the number of fatalities in Gram-negative bacteremia among hospital patients. The mortality from septic shock is still high despite recent developments in antibiotic therapy because antibiotics are unable to decrease the level of free lipopolysaccharide in the blood stream. Another approach to the treatment and prevention of septicaemia involves stimulation of an immune response against LPS. It was found that immunization with the core structures of endotoxin conjugated with proteins protected animals against infections and endotoxic shock. Anticonjugate sera are of great interest because they are directed against conserved parts of LPS and therefore could have cross-reactive and cross-protective properties with respect to many Gram-negative rods.
Important role of cardiac spect imaging in patients undergoing percutaneous transluminal coronary angioplasty. (1999)

To examine the utilization and contribution of cardiac perfusion scans to patients undergoing percutaneous transluminal coronary angioplasty.From July 1996 to January 1998, 34 patients underwent percutaneous transluminal coronary angioplasty and cardiac SPECT imaging was studied. Twenty-five patients had pre-procedure SPECT scans. The agreement between angioplasty strategies and SPECT findings of ischemia and hypokinesia was examined.When radionuclide imaging was performed before revascularization procedures, 84% of the patients had intervention strategies guided by scan findings. Perfusion scan findings including extent and severity of ischemia, degree of hypokinesia directed the selection of target vessel for angioplasty in the patient subgroup with multi-vessel disease. Post-angioplasty radionuclide cardiac scans were performed only on symptomatic patients, demonstrating ischemia and hypokinesia in most of them, conceivably reflected the selection bias.We recommend routine pre- and post-angioplasty radionuclide imaging with multigated scans for wall motion assessment for all patients receiving coronary intervention.
A Framework for supporting DBMS-like indexes in the cloud (2011)

To support "Database as a service" (DaaS) in the cloud, the database system is expected to provide similar functionalities as in centralized DBMS such as efficient processing of ad hoc queries. The system must therefore support DBMS-like indexes, possibly a few indexes for each table to provide fast location of data distributed over the network. In such a distributed environment, the indexes have to be distributed over the network to achieve scalability and reliability. Each cluster node maintains a subset of the index data. As in conventional DBMS, indexes incur maintenance overhead and the problem is more complex in the distributed environment since the data are typically partitioned and distributed based on a subset of attributes. Further, the distribution of indexes is not straight forward, and there is therefore always the question of scalability, in terms of data volume, network size, and number of indexes. In this paper, we examine the problem of providing DBMS-like indexing mechanisms in cloud DaaS, and propose an extensible, but simple and efficient indexing framework that enables users to define their own indexes without knowing the structure of the underlying network. It is also designed to ensure the efficiency of hopping between cluster nodes during index traversal, and reduce the maintenance cost of indexes. We implement three common indexes, namely distributed hash indexes, distributed B + -tree-like indexes and distributed multi-dimensional indexes, to demonstrate the usability and effectiveness of the framework. We conduct experiments on Amazon EC2 and an in-house cluster to verify the efficiency and scalability of the framework.
Overexpression of Id3 induces apoptosis of A549 human lung adenocarcinoma cells (2011)

Overexpression of Id3 triggered apoptosis in A549 human lung adenocarcinoma cells, implicating Id3 in negative control of tumour growth. These Id3-induced pro-apoptotic signalling pathways require further study, but this preliminary investigation suggests that Id3 regulation could be exploited in anti-tumour therapies.
Structural Variations of <i>N</i>‐Acetylneuraminic Acid, 10. Synthesis of 2,7‐, 2,8‐, and 2,9‐Dideoxy‐ and 2,4,7‐Trideoxy‐2,3‐didehydro‐<i>N</i>‐acetylneuraminic Acids and Their Behavior Towards Sialidase from <i>Vibrio cholerae</i> (1989)

Abstract The peracetylated methyl ester derivatives of 7‐deoxy‐Neu5Ac ( 2a ), 8‐deoxy‐Neu5Ac ( 3a , 9‐deoxy‐Neu5Ac ( 4a ), and 4,7‐dideoxy‐Neu5Ac ( 5a ) were transformed by trimethylsilyl trifluoromethanesulfonate into the corresponding 2‐deoxy‐2,3‐didehydro derivatives 2b–5b . As additional products, the 4,5‐oxazolino derivatives 6b–8b were formed. Hydrolysis of 2b–5b yielded the free acids 7‐deoxy‐Neu5Ac2en ( 2c ), 8‐deoxy‐Neu5Ac2en ( 3c ), 9‐deoxy‐Neu5Ac2en ( 4c ), and 4,7‐dideoxy‐Neu5Ac2en ( 5c ). They showed significantly different inhibitory influences on the hydrolysis of 4‐methylumbelliferyl‐α‐Neu5Ac by sialidase from Vibrio cholerae . The comparison of their evaluated α‐side profiles with that of Neu5Ac2en ( 1c ) enables a suitable explanation of their different inhibitory potencies.