gebhart/patrepeval huggingface dataset:
Randomized, comparative study of oral cefadroxil and cephalexin in lower respiratory infections in adults (1982)

Journal Article Randomized, comparative study of oral cefadroxil and cephalexin in lower respiratory infections in adults Get access C. Weingarten C. Weingarten Huntington HospitalHuntington, N. Y., U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 10, Issue suppl_B, 1982, Pages 109–113, https://doi.org/10.1093/jac/10.suppl_B.109 Published: 01 January 1982
The hormonal profile in ectopic pregnancies. (1994)

The hormonal profile in a patient with an ectopic pregnancy (EP) differs in many respects from that of a patient with a normal intrauterine pregnancy (IUP). Although there are several reports using different hormones for early diagnosis of ectopic pregnancy most of the results are contradictory. In this study, therefore, we prospectively investigated the maternal serum level of beta-human chorionic gonadotropin (beta-hCG), progesterone (P), estradiol (E2), human placental lactogen (HPL), alfafetoprotein (AFP) and cancer antigen 125 (CA 125) during the first trimester of normal and abnormal pregnancies. Serum samples were obtained from 20 women with normal IUPs, 15 women whose pregnancies complicated with spontaneous abortion and 31 women with surgically and pathologically confirmed EPs. The mean serum levels of beta-hCG, E2 and p in patients with EPs (9490.55 +/- 3071.2 mlU/ml, 100.1 +/- 22.09 pg/ml, 4.18 +/- 1.19 ng/ml, respectively) were significantly lower than those measured in normal IUPs (73796.8 +/- 15554.7 mlU/ml, 500.15 +/- 98.84 pg/ml, 19.2 +/- 2.8 ng/ml, respectively p < 0.001) and significantly lower than in patients with spontaneous abortion (22524 +/- 6213 mlU/ml, p < 0.05, 339.8 +/- 112.16 pg/ml, p < 0.01, 10.59 +/- 3.03 ng/ml, p < 0.05 respectively). No significant difference was recorded with respect to serum levels of HPL, AFP and CA 125 among the groups. We also investigated the diagnostic value of simple E2 and P in patients with EPs. We could not identify a discriminatory cutoff value because there was a considerable overlap in serum P and E2 levels between the patients with IUPs and EPs.(ABSTRACT TRUNCATED AT 250 WORDS)
Frajunolides E−K, Briarane Diterpenes from <i>Junceella fragilis</i> (2008)

Chemical investigation of the gorgonian octocoral Junceella fragilis, collected in Taiwan, resulted in the isolation of seven new briarane-type diterpenes, frajunolides E-K (1-7), in addition to 14 known briaranes, praelolide, junceellin, junceellolides A-E, and K, 11a,20a-epoxy-4-deacetoxyjunceelolide D, umbraculolide A, junceellonoid A, and juncins Y, Z, and ZI, as well as ergosterol peroxide. The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated.
A two-port SRAM for real-time video processor saving 53% of bitline power with majority logic and data-bit reordering (2006)

We propose a low-power two-port SRAM suitable for real-time video processing. In order to minimize discharge power on a read bitline, a majority-logic decides if input data are inverted in a write cycle, so that "1"s are in the majority. In video data, since more significant bits of adjacent pixel data are fortunately lopsided to either "0" or "1" with higher probability, the data bits in the pixels are reordered in each digit group to exploit the majority logic. The speed and area overheads are 4% and 11% in a 90-nm process technology, respectively. The proposed SRAM achieves 53% power reduction on the bitlines, and saves 43% of a total power when considered as an H.264 reconstructed-image memory.
Mysterious link between iron overload and CDKN2A/2B (2010)

Persistent oxidative stress has been associated with carcinogenesis. Iron overload is considered one such condition that causes oxidative stress. Epidemiological studies support a close link between iron overload and carcinogenesis. Reportedly, regular semiannual phlebotomies reduced cancer risk in an otherwise normal population. More specifically, genetic hemochromatosis, chronic viral hepatitis, ovarian endometriosis and asbestosis induce iron overload, which can lead to hepatocellular carcinoma, ovarian carcinoma or mesothelioma in humans. Through a combination of animal experiments and microarray analyses, homozygous deletion of CDKN2A/2B has been recognized as one of the major target genes involved in iron overload-induced carcinogenesis. CDKN2A/2B are the second most frequently inactivated tumor suppressing genes in human cancers. Currently, when infection is becoming sufficiently controlled worldwide, iron regulation may be the next target for human longevity.
Group A streptococci in the 1990s (2000)

The last decade has witnessed a remarkable change in the epidemiology of group A streptococcal infections. There has been a marked increase globally in the reporting of invasive infections caused by Streptococcus pyogenes, Lancefield group A streptococci. Many of these cases were deep-seated infections associated with shock and multi-organ failure and are defined as streptococcal toxic shock syndrome. In addition, reports of streptococcal sequelae, in particular, acute rheumatic fever, have re-emerged and remain a serious health threat in developed countries. It appears that these infections are related to the type distributions of the organism among the general population, with the re-emergence of more 'virulent' strains, such as the M1 serotype which in earlier decades was primarily seen in cases of either superficial disease or scarlet fever. Population-based surveillance studies have clearly indicated the importance and relevance of type identification for epidemiological purposes. There have also been suggestions that certain extracellular products and toxins play a major role in the so-called 'increased virulence' of the organism; these include cell surface molecules such as the M protein, opacity factor, the hyaluronic acid capsule, C5a peptidase and streptococcal inhibitor of complement (SIC), in addition to secreted proteins, pyrogenic exotoxins, cysteine proteinase, streptolysins O and S, hyaluronidase, streptokinase and other enzymes. All these factors, and events during the last decade, strongly emphasize the need for a better understanding of the epidemiology, pathogenesis, treatment and prevention of group A streptococcal infections.
A Simple Method For Preparation Of Nonthrombogenic Prothrombin Complex (1981)

Prothrombin complex concentrate (PCC) when infused into patients may produce thrombotic episodes, presumably due to the presence of some thrombogenic material. In order to prepare a safer PCC we have investigated whether the addition of purified antithrombin III (AT III) during an early stage of the isolation process would be effective in reducing thrombogenicity as assessed by the Wessler stasis model. By our method the cryosupernatant of plasma is adsorbed with DEAE-Sephadex (1.5 g/L), the unadsorbed fraction removed, the DEAE-cake washed with 0.7-1.0 plasma volume of citrate saline, followed by elution with 0.1 plasma volume of 0.03 M citrate containing 2 M NaCl and 0.25 AT III unit/ml, at pH 6.8. The eluted PCC is then concentrated and desalted by ultrafiltration, filtered, dispensed and lyophilized. In a bench-scale experiment starting from 6 L cryosupernatant, a PCC was obtained at 43% recovery and 50-fold purification over plasma based on Factor IX activity. The recoveries of Factors II, VII and X were 44, 23 and 64% respectively. The concentrate was free of detectable thrombin and plasmin and contained about 1 unit of AT III (determined immunologically) per 25 units of Factor IX. In the Wessler stasis model this PCC was nonthrombogenic at 100 Factor IX units per kilo body weight of the rabbit. Higher doses were not tried. A control PCC prepared without the addition of AT III to the DEAE-eluting buffer was nonthrombogenic at 50, but thrombogenic at 75 Factor IX units per kilo body weight of the rabbit. Subsequent incubation with AT III did not eliminate this thrombogenicity. These results suggest that AT III can be effective in preventing thrombogenicity in PCC but not in abolishing it if already developed.
Pulse polarography - theory and application. (1976)

Classical do polarography has been used widely for chemical analysis for both inorganic and organic compounds, and has an extensive literature (1). However, do polarography is not satisfactory at concentrations below about 10-5M, and resolution becomes very poor in the presence of a relatively large concentration of a more easily reduced depolarizer. For the purposes of improvement in sensitivity and resolution, a number of variations on do polarography have been developed (2). One of the best of these variations is pulse polarography. Pulse polarography was first developed by Barker (3) as the outgrowth of his work with square wave polarography. Several general articles on pulse polarography have been published (4-7). We present here the theory and applications of pulse polarography from an analytical point of view.
Binding of <i>Staphylococcus aureus</i> to milk fat globules increases resistance to penicillin-G (1997)

The susceptibility to penicillin-G of Staphylococcus aureus strains that cause mastitis was tested in milk and in Iso-sensitest broth (ISB): The minimal inhibitory concentrations (MIC) of beta-lactamase-positive strains in milk were 10-100-fold those in ISB, whereas the MIC of beta-lactamase-negative strains in milk were some 10-fold those in ISB; beta-lactamase production was induced by milk in beta-lactamase-positive strains. Much of the increase in resistance to penicillin-G caused by milk can be attributed to milk fat globules; the increase in resistance was related to the binding capacity of the bacteria to milk fat globules as well as to capsule formation by the bacteria. It appears that the binding of the staphylococci to the fat globules and bacterial capsule formation resulted in a biofilm type of growth. In this case, the staphylococci behaved differently from the planktonic type of growth in artificial broth medium in which antibiotic susceptibility testing is usually carried out.
The eyes and optic paths of the catfish, ameiurus (1941)

No Abstract.
Ribavirin Induces Polyamine Depletion via Nucleotide Depletion to Limit Virus Replication (2019)

Common antivirals include nucleoside or nucleotide analogs with base prodrugs. The antiviral ribavirin, a US Food and Drug Administration (FDA)-approved nucleoside antimetabolite, halts guanine production, mutagenizes viral genomes, and activates interferon signaling. Here, we find that ribavirin induces spermidine-spermine N1-acetyltransferase (SAT1), a polyamine catabolic enzyme. Polyamines are small, positively charged molecules involved in cellular functions such as transcription and translation. Previous work showed that SAT1 activation and polyamine depletion interfere with RNA virus replication. We show ribavirin depletes polyamines via SAT1, in conjunction with its known mechanisms. SAT1 transcripts, protein, and activity are induced in a dose-dependent manner, which depletes polyamine levels and reduces viral titers. Inhibition of SAT1 activity, pharmacologically or genetically, reduces ribavirin's effectiveness against three virus infection models. Additionally, ribavirin-mediated polyamine depletion results from nucleotide pool depletion. These data demonstrate another mechanism of ribavirin that inform its clinical effectiveness, which may provide insight for improved therapies.
Iron-Catalyzed Cross-Coupling of Primary and Secondary Alkyl Halides with Aryl Grignard Reagents (2004)

An iron-catalyzed cross-coupling reaction of a primary or secondary alkyl halide with an aryl Grignard reagent proceeds under mild conditions to give the corresponding coupling product in quantitative yield.
Optical bistability in amorphous Si–C alloys and amorphous alloy interference filters (1991)

Optical bistability with milliwatt cw switching powers was observed in tuned interference filters, based on band-gap-selected amorphous Si–C alloys in combination with layers of amorphous silicon nitride. Thermally induced optical switching by Ar-ion (514 nm) and He–Ne (633 nm) laser irradiation was demonstrated with fast switching speeds of 10–20 μsec. The thermo-optic coefficient dn/dT was measured to be 1.5 × 10−4 K−1 at 635 nm for a bulk sample with n = 2.0 and Eopt = 2.4 eV Values for the nonlinear index n2 and estimated sample temperature rises are also reported.
Fusion on 3D seismic exploration and seafloor geochemical survey (2006)

MH21 Research Consortium (Research Consortium for Methane Hydrate Resources in Japan) has conducted seafloor geochemical survey as an auxiliary method for exploration of methane hydrate reservoirs in the eastern Nankai Trough, offshore Japan. However, the geological and geochemical settings between methane hydrate reservoirs and seafloor in the eastern Nankai Trough are complex. Thus a geological and geochemical model in consideration of various settings in shallow formation is strongly required for success of seafloor geochemical survey to explore for methane hydrate reservoirs. MH21 Research Consortium conducted high-resolution 3D seismic survey to explore methane hydrate reservoirs in the eastern Nankai Trough. Because the high-resolution 3D seismic survey was designed for shallow formation where methane hydrates exist, excellent information about geological settings in shallow formation was obtained. Especially it provided us information about seafloor manifestations and migration conduits of hydrocarbon-bearing fluids in shallow formation. We carefully compared methane seep sites observed by submersibles with high-resolution 3D seismic sections data. There were some characteristic reflectors showing methane hydrate reservoirs and gas accumulations below seafloor at the sites. Bathymetric chart and seafloor reflection amplitude map constructed by waves reflected from seafloor provided detailed information about seafloor manifestations. The relationships between methane hydrate reservoirs and seafloor manifestations are becoming clear by interpretations of high-resolution 3D seismic data. MH21 Research Consortium will continue to conduct seafloor geochemical survey based on the geological and geochemical model constructed by high-resolution 3D seismic data in the future. In this paper, we introduce an attempt for exploration of methane hydrate reservoirs by ‘Fusion on 3D seismic exploration and seafloor geochemical survey’ in Japan.
Panoramic video stabilization based on rotational damping filter (2016)

Videos captured from handheld devices are commonly suffered from frame to frame jitter due to unintentional camera movements. Therefore a motion smoothing algorithm is required to produce stabilized video. In this paper a new method is proposed to stabilize panoramic videos from jitter using horizontal, vertical and rotational damping filters. Firstly speeded up robust features (SURF) are extracted from each frame of video sequence and motion estimation information is then obtained from two consecutive frames. Horizontal, vertical and rotational damping filters are applied on estimated motion to separate the intentional and unintentional motion in horizontal, vertical and rotational direction respectively. A motion compensated frame is created by translating the original frame using estimated unintentional motion information. It is evident from results that the proposed video stabilization algorithm outperforms the state-of-the-art method in terms of motion trajectories and interframe transformation fidelity for both panoramic and 3D video datasets.
A Multiple Inoculating Device for Bacteria (1967)

A Multiple Inoculating Device for Bacteria Get access Richard A. Murphy, M.S., Richard A. Murphy, M.S. College of Medicine, Department of Microbiology, University of Illinois at the Medical Center, Chicago, Illinois Search for other works by this author on: Oxford Academic Google Scholar Riaz-Ul Haque, Ph.D. Riaz-Ul Haque, Ph.D. College of Medicine, Department of Microbiology, University of Illinois at the Medical Center, Chicago, Illinois Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 47, Issue 4_ts, April 1967, Pages 554–555, https://doi.org/10.1093/ajcp/47.4_ts.554 Published: 01 April 1967 Article history Received: 27 June 1966 Published: 01 April 1967
Quantitative measurement of octopamines and synephrines in urine using capillary column gas chromatography negative ion chemical ionization mass spectrometry (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative measurement of octopamines and synephrines in urine using capillary column gas chromatography negative ion chemical ionization mass spectrometryKamal E. Ibrahim, Margaret W. Couch, Clyde M. Williams, Mary Beth. Budd, Richard A. Yost, and John M. MidgleyCite this: Anal. Chem. 1984, 56, 9, 1695–1699Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://pubs.acs.org/doi/10.1021/ac00273a037https://doi.org/10.1021/ac00273a037research-articleACS PublicationsRequest reuse permissionsArticle Views181Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor. (1976)

The mechanisms by which human high molecular weight kininogen (HMKrK) contributes to the surface-dependent activation of the Hageman factor systems have been studied. The ability of various mixtures of purified human Hageman factor (coagulation factor XII), HMrK, prekallikrein, and kaolin to activate coagulation factor XI was determined with factor XIa (activated factor XI) clotting assays. Hageman factor, HMrK and prekallikrein were required for maximal rates of activation of factor XI. A certain optimal mixture of purified Hageman factor, HMrK, prekallikrein, and kaolin gave the same rapid initial rate of activation of purified factor XI as an equivalent aliquot of factor XI-deficient plasma. This suggests that potent, surface-mediated activation of factor XI in plasma is explicable in terms of Hageman factor, HMrK, and prekallikrein. By studying separately some of the surface-dependent reactions involving Hageman factor, it was found that HMrK accelerated by at least an order of magnitude the following reactions: (i) the activation of factor XI by activated Hageman factor; (ii) the activation of prekallikrein by activated Hageman factor; and (iii) the activation of Hageman factor by kallikrein. Stoichiometric rather than catalytic amounts of HMrK gave optimal activation of factor XI. These results are consistent with the hypothesis that HMrK and Hageman factor form a complex on kaolin which renders Hageman factor more susceptible to proteolytic activation by kallikrein and which facilitates the action of activated Hageman factor on its substrate proteins, factor XI and prekallikrein.
Temporal information integration for video semantic segmentation (2020)

We present a temporal Bayesian filter for semantic segmentation of a video sequence. Each pixel is a random variable following a discrete probabilistic distribution function representing possible semantic classes. Bayesian filtering consists in two main steps: 1) a prediction model and 2) an observation model (likelihood). We propose to use a datadriven prediction function derived from a dense optical flow between images t and t + 1 achieved by a deep neural network [1]. Moreover, the observation function uses a semantic segmentation network. The resulting approach is evaluated on the public dataset Cityscapes. We show that using the temporal filtering increases the accuracy of the semantic segmentation.
Intrapartum Surveillance of IUGR Fetuses with Cardiotocography and Fetal Pulse Oximetry (2003)

In IUGR fetuses, FSPO2 values less than 34% represent an acidotic status, while values of > or =35% are well tolerated. Fetal pulse oximetry proved reliable, according to umbilical cord blood measurements and Apgar scores, reducing cesarean deliveries in cases of nonreassuring cardiotocographic patterns in IUGR fetuses.
Enhanced Toxic Metal Accumulation in Engineered Bacterial Cells Expressing <i>Arabidopsis thaliana</i> Phytochelatin Synthase (2003)

Phytochelatins (PCs) are metal-binding cysteine-rich peptides, enzymatically synthesized in plants and yeasts from glutathione in response to heavy metal stress by PC synthase (EC 2.3.2.15). In an attempt to increase the ability of bacterial cells to accumulate heavy metals, the Arabidopsis thaliana gene encoding PC synthase (AtPCS) was expressed in Escherichia coli. A marked accumulation of PCs was observed in vivo together with a decrease in the glutathione cellular content. When bacterial cells expressing AtPCS were placed in the presence of heavy metals such as cadmium or the metalloid arsenic, cellular metal contents were increased 20- and 50-fold, respectively. We discuss the possibility of using genes of the PC biosynthetic pathway to design bacterial strains or higher plants with increased abilities to accumulate toxic metals, and also arsenic, for use in bioremediation and/or phytoremediation processes.
Land multiple attenuation — The future is bright (2006)

The application of multiple elimination technology on land seismic data is not always straightforward. Contrary to marine environment, land multiple attenuation requires careful preprocessing and innovative thinking. A complex near‐surface, combined with poor signal‐to‐noise and source/receiver coupling issues, are key obstacles which deteriorate the performance of multiple attenuation algorithms. In this paper, we briefly review model‐based and data‐driven algorithms for the suppression of multiple energy on land seismic data. We then propose a novel, model‐based methodology rooted to the path‐summation technology, which takes into account the unique characteristics of land seismic data. Finally, we conclude with some comments related to the new inverse data approach and its applicability for land multiple elimination.