gebhart/patrepeval huggingface dataset:
MRI and CSF biomarkers in normal, MCI, and AD subjects (2009)

CSF and MRI biomarkers independently contribute to intergroup diagnostic discrimination and the combination of CSF and MRI provides better prediction than either source of data alone. However, MRI provides greater power to effect cross-sectional groupwise discrimination and better correlation with general cognition and functional status cross-sectionally. We therefore conclude that although MRI and CSF provide complementary information, MRI reflects clinically defined disease stage better than the CSF biomarkers tested.
The Correspondence of Vocal Tract Resonance With Volumes Obtained From Magnetic Resonance Images (1992)

The increasing availability of magnetic resonance imaging (MRI) as a research, and even clinical, tool in speech production makes possible a wide range of quantitative methods in vocal tract measurement. In these initial stages of application, it is essential that the limits of the method be identified. The present investigation was designed to apply the techniques of digital image analysis and volumetric measurement to MRIs obtained for the vocal tract during production of continuant speech sounds, and to apply these measures to a well-established and thoroughly tested model of acoustic transmission (Stevens & House, 1955). The results demonstrated that, although there were several sources of relatively large error and measurement bias, the vocal tract volumes obtained from MRIs were significantly predictive of vocal tract resonance frequencies. These results are discussed with respect to limits and potential for future application of MRI to speech production research.
Performance of 18 Polymers in Aluminum Citrate Colloidal Dispersion Gels (1995)

ABSTRACT Colloidal dispersion gels are made up of low concentrations of polymer and aluminum citrate in water. These gels, which are mixed as a homogeneous solution at the surface, provide a valuable tool for in-depth blockage of high permeability regions of rock in heterogeneous reservoirs. Performance of colloidal dispersion gels depends strongly on the type and quality of polymer used. This paper provides an overview of the performance of 18 different polymers in colloidal dispersion gels. 14 of the polymers were partially hydrolyzed polyacrylamides or AMPS polymers in dry crystalline form with varying degrees of hydrolysis and molecular weight. The group also includes one cationic polyacrylamide, one carboxymethyl cellulose, one partially hydrolyzed polyacrylamide in emulsion form and one polysaccharide in dry form. Gels were mixed with the polymers at two polymer concentrations, three polymer:aluminum ratios and in different concentrations of potassium chloride. The gels were quantitatively tested at 1, 7, 14 and 28 days after crosslinking using the transition pressure test, which is a screen flow resistance test. Of the six polymer types tested, only the dry partially hydrolyzed polyacrylamides and AMPS polymers formed colloidal dispersion gels. Gel strength generally increased with increasing anionic charge and molecular weight; however, the manner in which the polymer is manufactured and the impurities present in the polymer also play roles which are more significant than originally expected.
Assessing the clinical applicability of prior head imaging in patients with chronic rhinosinusitis (2017)

Background Patients often have received some modality of head imaging prior to being evaluated for chronic sinonasal complaints, and the clinical significance of these scans on current sinonasal symptomatology is unknown. Methods We performed a retrospective, cohort study of 578 patients with chronic sinonasal indications for maxillofacial computed tomography scans (CTs) in 2016. Patients were included if previous head cross‐sectional imaging had been performed. Lund‐McKay (LM) scores were calculated on the prior CT scan for each patient and compared to LM scores of the most recent scan. Scans with LM scores ≤3 were deemed normal, scores >3 were deemed positive, and Δ >3 was deemed a significant change. Results Of 578 patients, 153 (26.5%) patients had previous imaging. Overall, a strong correlation was noted between scans ( r = 0.791, p < 0.001). Significant correlations remained with the subset of positive prior scans ( r = 0.743, p < 0.001). The 3 most common prior imaging modalities were maxillofacial CT, head CT, and brain magnetic resonance imaging (MRI). Correlations between these modalities and subsequent maxillofacial CTs range from strong to moderately strong. Women were significantly more likely to have negative prior imaging ( p = 0.048). Patients with negative prior imaging (80/153) were significantly more likely to remain unchanged (71/80) compared to patients with positive prior scans (56/73) ( p = 0.023). Conclusion Prior head imaging highly correlates to future maxillofacial CT in patients with chronic sinonasal complaints, and patients with prior negative scans are likely to remain negative on future imaging. If prior head scans exist, practitioners may want to avoid ordering additional scans in the absence of changing symptoms.
The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons (2006)

In response to behaviorally salient stimuli, dopamine (DA) neurons fire in bursts. Burst firing induces a large transient increase in synaptic DA and is regarded as the functionally relevant mode of transmission that signals reward and modulates goal-directed behavior. DA neuron burst firing is dynamically regulated by afferent inputs, and it is not present in vitro because of severing of afferent processes. However, what afferents are requisite for burst firing in vivo is not known. Here, we show that tonic input from the laterodorsal tegmental nucleus (LDTg) is required for glutamate-elicited burst firing in ventral tegmental area DA neurons of anesthetized rats. Also, after LDTg inactivation, DA neurons fire as they do in vitro (i.e., as pacemakers); even direct glutamate application fails to cause them to burst fire under these conditions. These data show that the LDTg is critical to normal DA function, and thus, pathology within this region may lead to aberrant DA signaling.
Event Detection in Crowded Videos (2007)

Real-world actions occur often in crowded, dynamic environments. This poses a difficult challenge for current approaches to video event detection because it is difficult to segment the actor from the background due to distracting motion from other objects in the scene. We propose a technique for event recognition in crowded videos that reliably identifies actions in the presence of partial occlusion and background clutter. Our approach is based on three key ideas: (1) we efficiently match the volumetric representation of an event against oversegmented spatio-temporal video volumes; (2) we augment our shape-based features using flow; (3) rather than treating an event template as an atomic entity, we separately match by parts (both in space and time), enabling robustness against occlusions and actor variability. Our experiments on human actions, such as picking up a dropped object or waving in a crowd show reliable detection with few false positives.
Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy (2000)

Diabetic polyneuropathy is a serious complication in patients with diabetes mellitus. In addition to the maintenance of a sufficient metabolic control, alpha-lipoic acid (ALA) (Thioctacid, Asta Medica) is known to have beneficial effects on diabetic polyneuropathy although the exact mechanism by which ALA exerts its effect is unknown. In order to study the effect of ALA on microcirculation in patients with diabetes mellitus and peripheral neuropathy one group of patients (4 female, 4 male, age 60+/-3 years, diabetes duration 19+/-4 years, BMI 24.8+/-1.3 kg/m2) received 1200 mg ALA orally per day over 6 weeks (trial 1). A second group of patients (5 female, 4 male, age 65+/-3 years, diabetes duration 14+/-4 years, BMI 23.6+/-0.7 kg/m2) was studied before and after they had received 600 mg ALA or placebo intravenously over 15 minutes in order to investigate whether ALA has an acute effect on microcirculation (trial 2). Patients were investigated by nailfold video-capillaroscopy. Capillary blood cell velocity was examined at rest and during postreactive hyperemia (occlusion of the wrist for 2 minutes, 200 mmHg) which is a parameter of the perfusion reserve on demand. The oral therapy with ALA resulted in a significant decrease in the time to peak capillary blood cell velocity (tpCBV) during postocclusive hyperemia (trial 1: 12.6+/-3.1 vs 35.4+/-10.9 s, p<0.05). The infusion of ALA also decreased the tpCBV in patients with diabetic neuropathy (trial 2: before: 20.8+/-4,5, ALA: 11.74+/-4.4, placebo: 21.9-5.0 s, p<0.05 ALA vs both placebo and before infusions) indicating that ALA has an acute effect on microcirculation. Capillary blood cell velocity at rest (rCBV), hemodynamic parameters, hemoglobinA1c and local skin temperature remained unchanged in both studies. These results demonstrate that in patients with diabetic polyneuropathy ALA improves microcirculation as indicated by an increased perfusion reserve on demand. The observed effects are apparently acute effects. With the restriction of the pilot character of this investigation the findings support the assumption that ALA might exert its beneficial effects at least partially by improving microcirculation which is likely to occur also at the level of the vasa nervorum.
Designing telecommunications networks using genetic algorithms and probabilistic minimum spanning trees (1994)

In this paper we investigate genetic algorithms (GA) as a .heuristic technique for obtaining near optimal solutions to the probabilistic minimum spanning tree (PMST) problem. The PMST problem is a natural generalization of the classical minimum spanning tree (MST) problem and is frequently a more realistic model. The PMST problem addresses the circumstances that arise when not all nodes are deterministically present but, rather, nodes are present with known probabilities. Although there are some special cases that are solvable in polynomial time, it is known that the PMST problem is NP-complete.
The neuropathology of intervertebral discs removed for low‐back pain (1980)

Thirty lower lumbar intervertebral discs (IVDs) removed for low-back pain were examined. There is a profuse non-myelinated axonal network and abundant free nerve terminals in the outer (lateral) half of the annulus fibrosus. The inner annulus and the nucleus pulposus did not contain nerve terminals. No significant changes in the nerve networks could be demonstrated in degenerate IVDs: in particular, ingrowth of nerve terminals into foci of granulomatous tissue was not seen. Early foci of degeneration are clearly shown by Marshall's silver method for metalophil cells. Mucinous filaments are argyrophilic and can be mistaken for axonal structures in the nucleus pulposus.
Civil Justice: A Model for the Community (2000)

I n association with the School of Law, C ivil Justice Inc. (C] ) enables recent graduates to gain experience while serving the community. A growing network of more than two dozen attorneys, CJ provides high-quali ty low-cost representation for lowto moderate-income clients. CJ was established in September 1998 th rough a grant from the Open Society Institute of the Soros Foundation, a group that funds programs worldwide and wo rks fo r legal reform. Currently, attO rneys in the program are worki ng tOward providing low-cost settlement representation to first-time home buyers. CJ assembles a panel oflawyers to represent clients so they wouldn' t be subjected to fraudulent practices. his happens qui te often, acco rding to Denis Murphy, C]'s executive directOr and a boa rd member, most first-time home buyers don' t consult with a lawyer before settlement due to the extra expense. In addition to helping clients, CJ a great resource for new and solo practitioners, M urphy explains. Through the network, recent graduates are able to bounce questions and suggestions off each other, which proves (0 be helpful when they are just starting out. Nevett Steele J r. '67, board member and acting chairperson of CJ, agrees. H aving this network also takes the loneliness and fright out of being a solo practitioner. Each CJ attorney has an Internet connection and may log on daily for online discussions. T his cooperative group effort has helped make the program a success. Ann M. Lembo '95, who began her own practice two years ago and considers herself a commu nity attOrney, hopes the networking sys tem wiLl continue to grow. As we build our practices and become more experienced, we should need less support from Civil Justice. T hen our roles will change, and we will become the mentOrs. T he network will be an incubatO r for new attOrneys who want to do well while doing good for the comm uni ty. Denis M urphy says that while current funding is generous, the program operates on a grant requiring annual renewal. And because there are no guarantees for future
A 35-177 mum Tunable Intersubband Emitter for the Far-Infrared (1998)

Under the influence of a perpendicular electric field the mini-bands of a superlattice break up and from localised electron states within each quantum well. The energy separation between adjacent well states is proportional to the field and the system has become known as a Stark Ladder. This work investigates the potential of superlattices within the Stark Ladder regime as tunable intersubband emitters for the far-infrared region of the spectrum.
Sir Thomas West and the Statute of Rapes, 1382 (1980)

Sir Thomas West and the Statute of Rapes, 1382 Get access J. B. POST J. B. POST Search for other works by this author on: Oxford Academic Google Scholar Bulletin of the Institute of Historical Research, Volume 53, Issue 127, May 1980, Pages 24–30, https://doi.org/10.1111/j.1468-2281.1980.tb01726.x Published: 12 October 2007
Contribution à l'étude de la synchronisation des oscillateurs : intégration des oscillateurs synchrones dans les systèmes radiofréquences en technologie silicium (2000)

Ce memoire de these s'interesse aux problemes poses par l'integration dans les technologies silicium des synthetiseurs de frequence dans la gamme 1-5 GHz. Il est montre que l'integration des architectures classiques n'est pas envisageable car la consommation excessive et le bruit de phase obtenus sont incompatibles avec les specifications des applications radiofrequences modernes. Dans ce memoire, un oscillateur original capable de se verrouiller sur l'harmonique d'un signal d'entree basse frequence appele Oscillateur Synchrone (OS) est presente. Une etude theorique permettant de prevoir la plage de synchronisation de l'OS est proposee rendant ainsi possible une conception optimisee. D'autre part elle confirme les proprietes attendues des OS, en particulier la recopie du bruit de phase du signal de synchronisation, au facteur de multiplication pres. Deux prototypes d'OS, integres dans une technologie BiCMOS 0,8 μm, sont decrits. Le premier oscille aux alentours de 2,4 GHz et est synchronise par un signal de frequence voisine de 400 MHz.. Sa plage de synchronisation de 12 MHz . Le deuxieme prototype est une version optimisee, a partir de la theorie developpee, oscillant aux alentours de 2 GHz. Il est synchronise par un signal de frequence voisine de 330 MHz. Sa plage de synchronisation est de 112 MHz environ permettant de couvrir la plage de reception ou d'emission de l'application UMTS2000. Ces deux prototypes confirment les avantages de l'OS dans une architecture de synthetiseur a boucle double par le report des contraintes de bruit de phase sur la boucle basse frequence et par sa consommation bien moins elevee qu'une boucle a verrouillage de phase fonctionnant a la meme frequence. Un dernier prototype implante dans la technologie CMOS 0,25 μm de STMicroelectronics est ensuite decrit. Cet OS oscille a 5,2 GHz et presente une plage de synchronisation de 160 MHz lorsqu'un signal a 900 MHz est applique sur son entree (6eme sous harmonique).
Retroviral‐mediated transfer of a dystrophin minigene into <i>mdx</i> mouse myoblasts in vitro (1992)

We have demonstrated expression of a 6.3 kb Becker muscular dystrophy (BMD) human dystrophin cDNA following retroviral-mediated transduction of cultured myoblasts from the dystrophin-deficient mdx mouse. The truncated dystrophin protein was localised to the sarcolemma of differentiated myotubes by antibodies against the C-terminus of the molecule, and produced an identical immunostaining pattern to that observed in control myotubes expressing normal endogenous dystrophin. These results indicate that retroviral-mediated gene transfer may be useful for experimental in vivo studies on the complementation of dystrophin gene mutations.
Cerebrospinal fluid tau and amyloid-β<sub>1-42</sub>in patients with dementia (2015)

Progressive cognitive decline in combination with a cerebrospinal fluid biomarker pattern of low levels of amyloid-β1-42 and high levels of total tau and phosphorylated tau is typical of Alzheimer's disease. However, several neurodegenerative disorders may overlap with Alzheimer's disease both in regards to clinical symptoms and neuropathology. In a uniquely large cohort of dementia patients, we examined the associations of cerebrospinal fluid biomarkers for Alzheimer's disease molecular pathology with clinical dementia diagnoses and disease severity. We cross-referenced the Swedish Dementia Registry with the clinical laboratory database at the Sahlgrenska University Hospital. The final data set consisted of 5676 unique subjects with a clinical dementia diagnosis and a complete set of measurements for cerebrospinal fluid amyloid-β1-42, total tau and phosphorylated tau. In cluster analysis, disregarding clinical diagnosis, the optimal natural separation of this data set was into two clusters, with the majority of patients with early onset Alzheimer's disease (75%) and late onset Alzheimer's disease (73%) assigned to one cluster and the patients with vascular dementia (91%), frontotemporal dementia (94%), Parkinson's disease dementia (94%) and dementia with Lewy bodies (87%) to the other cluster. Frontotemporal dementia had the highest cerebrospinal fluid levels of amyloid-β1-42 and the lowest levels of total tau and phosphorylated tau. The highest levels of total tau and phosphorylated tau and the lowest levels of amyloid-β1-42 and amyloid-β1-42:phosphorylated tau ratios were found in Alzheimer's disease. Low amyloid-β1-42, high total tau and high phosphorylated tau correlated with low Mini-Mental State Examination scores in Alzheimer's disease. In Parkinson's disease dementia and vascular dementia low cerebrospinal fluid amyloid-β1-42 was associated with low Mini-Mental State Examination score. In the vascular dementia, frontotemporal dementia, dementia with Lewy bodies and Parkinson's disease dementia groups 53%, 34%, 67% and 53% of the subjects, respectively had abnormal amyloid-β1-42 levels, 41%, 41%, 28% and 28% had abnormal total tau levels, and 29%, 28%, 25% and 19% had abnormal phosphorylated tau levels. Cerebrospinal fluid biomarkers were strongly associated with specific clinical dementia diagnoses with Alzheimer's disease and frontotemporal dementia showing the greatest difference in biomarker levels. In addition, cerebrospinal fluid amyloid-β1-42, total tau, phosphorylated tau and the amyloid-β1-42:phosphorylated tau ratio all correlated with poor cognitive performance in Alzheimer's disease, as did cerebrospinal fluid amyloid-β1-42 in Parkinson's disease dementia and vascular dementia. The results support the use of cerebrospinal fluid biomarkers to differentiate between dementias in clinical practice, and to estimate disease severity.
Regional lymph node metastases in carcinoma of the left side of the colon and rectum: CT demonstration. (1992)

The distribution of regional lymph node metastases in carcinoma of the left side of the colon, rectum, and anus can be well shown by routine CT of the abdomen and pelvis. Recognition of the location of nodes in the mesocolic, left colic, and IMA nodal groups can help in developing a systematic approach to the detection of nodal metastasis. This can be especially important in preoperative planning for cases in which resection may be curative. In addition, an understanding of the distribution of nodal metastasis will make it possible to recognize early recurrent nodal disease, particularly with an increase in associated increase in levels of carcinoembryonic antigen, and to predict certain clinical sequences such as hydronephrosis of the left kidney associated with left colic nodal metastases.
Alzheimer´s Disease and Oxidative Stress: A Review (2013)

Alzheimer´s disease (AD) is a neurodegenerative disorder with no known cure and rapid rise in incidence. The predominant cognitive impairment is currently treated using cognitive enhancers like cholinesterase inhibitors. The two molecular hallmarks of AD are amyloid plaques created from an amyloid precursor protein and hyperphosphorylated tau protein that is deposited as neurofibrillary tangles inside neurons. A number of pathological mechanisms follow or precede these formations. Alteration in mitochondrial function and deposition of heavy metals are reported. The disease progression is enhanced by oxidative stress. However, the role of oxidative stress is not universally accepted. The current review covers and discusses the basic evidence and role of oxidative stress in AD development.
Seismic wavelet estimation constrained by well data using artificial neural networks (2000)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2000Seismic wavelet estimation constrained by well data using artificial neural networksAuthors: Zhengping LiuJ. P. CastagnaZhengping LiuUniversity of Oklahoma and J. P. CastagnaUniversity of Oklahomahttps://doi.org/10.1190/1.1815962 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1815962FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 2000ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2000 Pages: 2484 publication data© 2000 Copyright © 2000 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 04 Jan 2005 CITATION INFORMATION Zhengping Liu and J. P. Castagna, (2000), "Seismic wavelet estimation constrained by well data using artificial neural networks," SEG Technical Program Expanded Abstracts : 2460-2463. https://doi.org/10.1190/1.1815962 Plain-Language Summary PDF DownloadLoading ...
THE FREE ENERGY OF HYDROCHLORIC ACID IN AQUEOUS SOLUTION. (1916)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTTHE FREE ENERGY OF HYDROCHLORIC ACID IN AQUEOUS SOLUTION.James H. EllisCite this: J. Am. Chem. Soc. 1916, 38, 4, 737–762Publication Date (Print):April 1, 1916Publication History Published online1 May 2002Published inissue 1 April 1916https://pubs.acs.org/doi/10.1021/ja02261a001https://doi.org/10.1021/ja02261a001research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts