gebhart/patrepeval huggingface dataset:
SUMOylation Interferes with CCAAT/Enhancer-Binding Protein β-Mediated c- <i>myc</i> Repression, but Not IL-4 Activation in T Cells (2006)

The transcription factor C/EBPbeta transactivates the IL-4 gene in murine T lymphocytes and facilitates Th2 cell responses. In this study, we demonstrate that C/EBPbeta also acts as a repressor of T cell proliferation. By binding to the c-myc promoter(s), C/EBPbeta represses c-Myc expression and, therefore, arrests T cells in the G1 phase of the cell cycle. For C/EBPbeta-mediated repression, the integrity of its N-terminal transactivation domain is essential whereas the central regulatory domain is dispensable. This central regulatory domain is sumoylated in vivo which leads to an alteration of the activity of C/EBPbeta. Whereas sumoylation does not affect the C/EBPbeta-mediated activation of the IL-4 gene, it relieves its repressive effect on c-Myc expression and T cell proliferation. Similar to several other transcription factors, sumoylation redistributes nuclear C/EBPbeta and targets it to pericentric heterochromatin. These results suggest an important role of sumoylation in adjusting the finely tuned balance between proliferation and differentiation in peripheral T cells which is controlled by C/EBPbeta.
Environmental Odours from Australian Piggeries (1999)

Building and pond emission rates, measured as part of a project funded by the Pig Research and Development Corporation (PRDC), are combined to give high and low estimates of the total odour emissions from typical piggeries. These are used in the Gaussian dispersion model AUSPLUME to predict 99.5 percentile contours of odour concentration, that is, the odour concentrations that would be equalled or exceeded 0.5 % of the time. The paper shows that the range of emission rates possible for a piggeiy of given size, and the subsequent range in predicted odour concentration surrounding the site can lead to very different estimates of the possible odour impact of that piggery. High odour concentrations were shown to occur at very large distances from a piggery, with potentially nuisance concentrations possible at distances up to 12 km from the site. The limitations of the data and the modelling are discussed as are the implications of the high predicted concentrations.
Correlation of tubulin-binding and antitumor activities of podophyllotoxin analogs. (1978)

The tubulin-binding affinities of podophyllotoxin and 12 related compounds have been compared with the effectiveness of these drugs in three assays of antitumor activity: (1) The mastocytoma assay of inhibited tumor cell growth in vitro; (2) the 37 sarcoma assay of tumor remission in vivo; and (3) the Stentor regeneration inhibition assay which detects a requirement for microtubule polymerization. The results indicate that there is a positive Spearman rank correlation coefficient between the inhibition constant for the binding of colchicine to tubulin in the presence of these compounds and the effectiveness of the compounds in the three assays of tumor growth inhibition. It is suggested that tubulin-binding assays may be a useful step in the screening of podophyllotoxin-like compounds suspected of disrupting mitosis by binding to microtubule protein.
GP-RVM: Genetic Programing-based Symbolic Regression Using Relevance Vector Machine (2018)

This paper proposes a hybrid basis function construction method (GP-RVM) for Symbolic Regression problem, which combines an extended version of Genetic Programming called Kaizen Programming and Relevance Vector Machine to evolve an optimal set of basis functions. Different from traditional evolutionary algorithms where a single individual is a complete solution, our method proposes a solution based on linear combination of basis functions built from individuals during the evolving process. RVM which is a sparse Bayesian kernel method selects suitable functions to constitute the basis. RVM determines the posterior weight of a function by evaluating its quality and sparsity. The solution produced by GP-RVM is a sparse Bayesian linear model of the coefficients of many non-linear functions. Our hybrid approach is focused on nonlinear white-box models selecting the right combination of functions to build robust predictions without prior knowledge about data. Experimental results show that GP-RVM outperforms conventional methods, which suggest that it is an efficient and accurate technique for solving SR. The computational complexity of GP-RVM scales in $O( M^{3})$, where $M$ is the number of functions in the basis set and is typically much smaller than the number $N$ of training patterns.
Quantitative immunoassay of anti‐la antibodies using purified recombinant la antigen (1988)

A purified recombinant La fusion protein was tested in an enzyme-linked immunosorbent assay to quantitate anti-La responses. This protein contained the immunodominant region of the La molecule fused to beta-galactosidase. In solid-phase assays, recombinant La protein was solubilized in urea and bound to polystyrene wells without loss of immunoreactivity. The recombinant-based enzyme-linked immunosorbent assay proved to be a sensitive method for the detection of anti-La binding, and it accurately distinguished anti-La precipitin positive sera from normal sera.
Revision of the genera <i>Sporormia</i> and <i>Sporormiella</i> (1972)

The genus Sporormia is restricted to the type species S. fimetaria DeNot., S. fimicola Ahmed & Asah and S. mirabilis Bret. & Faur., in which the ascospores are arranged in a truncate bundle, parallel to the ascus and surrounded by a common gelatinous sheath. The cells of the ascospores are without germ slits.In Sporormiella, which is regarded as a distinct genus, the ascospores are not arranged in a truncate bundle. Each spore has a distinct and separate gelatinous sheath and each cell of the ascospore has an elongated germ slit. The type species is S. nigropurpurea Ell. & Ev.The following 35 species of Sporormia are transferred to Sporormiella: S. affinis Sacc., S. americana Griff., S. antarctica Speg., S. australis Speg., S. bipartis Cain, S. capybarae Speg., S. chaetomioides Griff., S. commutata Niessl, S. corynespora Niessl, S. dakotensis Griff., S. heptamera Auersw., S. herculea Ell. & Ev., S. insignis Niessl, S. irregularis I. Egel., S. kansensis Griff., S. lageniformis Fuckel, S. lata Griff., S. leporina Niessl, S. longispora Cain, S. megalospora Auersw., S. minima Auersw., S. muskokensis Cain, S. ontariensis Cain, S. ovina (Desm.) Sacc., S pascua Niessl, S. pentamera Oud., S. pilosa Cain, S. pilosella Cain, S. polymera Cain, S. pulchella Hansen, S. pyriformis Speg., S. scandinavica I. Egel., S. schoterriana Bret. & Faur., S. splendens Cain, S. vexans Auersw.There are 22 new species described in the genus Sporormiella, as follows: S. alloimera, S. anisomera, S. calomera, S. cylindrospora, S. cymatomera, S. decamera, S. dodecamera, S. dubia, S. euryspora, S. isomera, S. longisporopsis, S. minimoides, S. minipascua, S. octonalis, S. platymera, S. schadospora, S, septenaria, S. systenospora, S. subtilis, S. teretispora, S. tetramera, S. trogospora.These coprophilous species are from Argentina, Canada, Mexico, and the United States.A total of 66 species are described, 61 of which are illustrated. Keys to the species of Sporormia and Sporormiella are included.
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF (2003)

Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF)-related adaptor molecule (TRAM) is the fourth TIR domain-containing adaptor protein to be described that participates in Toll receptor signaling. Like TRIF, TRAM activates interferon regulatory factor (IRF)-3, IRF-7, and NF-kappaB-dependent signaling pathways. Toll-like receptor (TLR)3 and 4 activate these pathways to induce IFN-alpha/beta, regulated on activation, normal T cell expressed and secreted (RANTES), and gamma interferon-inducible protein 10 (IP-10) expression independently of the adaptor protein myeloid differentiation factor 88 (MyD88). Dominant negative and siRNA studies performed here demonstrate that TRIF functions downstream of both the TLR3 (dsRNA) and TLR4 (LPS) signaling pathways, whereas the function of TRAM is restricted to the TLR4 pathway. TRAM interacts with TRIF, MyD88 adaptor-like protein (Mal)/TIRAP, and TLR4 but not with TLR3. These studies suggest that TRIF and TRAM both function in LPS-TLR4 signaling to regulate the MyD88-independent pathway during the innate immune response to LPS.
Computing Optimal Randomized Resource Allocations for Massive Security Games (2011)

Providing security for transportation systems, computer networks, and other critical infrastructure is a large and growing problem. Central to many of these security problems is a resource allocation task. For example, a police force may have limited personnel to conduct patrols, operate checkpoints, and conduct random searches. Other scarce resources including bomb-sniffing canines, vehicles, and security cameras. The key question is how to efficiently allocate these resources to protect against a wide variety of potential threats.
Calcitonin and 1,25-dihydroxyvitamin D3 receptors in human breast cancer cell lines. (1980)

Five human breast cancer cell lines (MCF 7, T 47D, BT 20, MDA 157, and MDA 231) and a human breast epithelial cell line (HBL 100) have been found to contain specific high-affinity receptors for 1,25-dihydroxyvitamin D3, Kd values ranged from 0.6 to 2.0 X 10(-11) M and receptor concentration from 31 to 150 fmol/mg cytosol protein. Two of the breast cancer lines (MCF 7 and T 47D) contain specific high-affinity receptors for calcitonin and a calcitonin-responsive adenylate cyclase, which have been characterized with the aid of salmon, eel, and human calcitonins and in several substituted analogues of human calcitonin. The 1,25-dihydroxyvitamin D3 receptor may reflect a normal property of the breast cell. Breast cancer cell lines provide a useful source of 1,25-dihydroxyvitamin D3 receptors. Their coexistence with a calcitonin receptor and biological response in some breast cancers offers the opportunity to investigate new aspects of breast cancer endocrinology.
Organic-Inorganic CO<sub>2</sub>Selective Membranes Prepared by the Sol-Gel Process (2009)

Abstract Composite membranes prepared from mixtures of 3-glycidoxypropyl trimethoxysilane (GPTMS) and different diamines containing polyether segments were synthesized by the sol-gel process. The membranes were obtained by coating asymmetric porous polyacrylonitrile (PAN) supports with the silane solutions. The composite membranes were characterized by single and mixed gas permeation and by atomic force microscopy. The selectivity increased by increasing the molecular weight of the poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol)bis(2-aminopropyl ether) (PAPE), and also with the addition of poly(ethylene glycol) (PEG) to the coating solution. The CO2/N2 selectivity values up to 75 and the CO2/CH4 selectivity values up to 20 were measured. High gas selectivity was also confirmed by measurements with mixed gas feed, although slightly lower than in the measurements with single gases. Keywords: CO2/N2 separationepoxy silanegas separationorganic-inorganic membranessol-gel
Recent Updates of Irisinandrsquo;s Anti-Obesity Research (2020)

Obesity, one of the most common metabolic disorders, has become a worldwide disease that poses substantial health and economic burdens to individuals and society. Recently, “browning” of human white adipose tissue has become an attractive therapeutic strategy for the management of obesity and obesity-related metabolic diseases as the fat-burning brown-like beige adipose tissue enhances whole-body energy metabolism. Irisin, a hormone secreted by skeletal muscle and other organs after exercise and cold exposure, gives rise to keen interest because of its promising therapeutic potential for the browning of white adipocytes. This review will cover recent major progresses in the “anti-obesity” research of irisin with an emphasis on the browning effect of irisin in human. We further discuss emerging questions and new directions in the irisin research.
Longitudinal evaluation of cytogenetic aberrations in prostatic cancer: tumours that recur in time display an intermediate genetic status between non-persistent and metastatic tumours (1998)

Only limited data are available on chromosomes specifically involved in prostatic tumour progression. This study has evaluated the cytogenetic status of primary prostatic carcinomas, local tumour recurrences, and distant metastases, representing different time points in prostatic tumour progression. Interphase in situ hybridization (ISH) was applied with a set of (peri) centromeric DNA probes, specific for chromosomes 1, 7, 8 and Y, to routinely processed tissue sections of 73 tumour specimens from 32 patients. Longitudinal evaluation was possible in 11 cases with local recurrence and nine cases with distant metastases. The remaining 12 patients showed no evidence of local recurrence or distant metastasis after radical prostatectomy on follow-up (mean 60.5 months) and served as a reference. Numerical aberrations of at least one chromosome were found in 27 per cent of the local recurrences and 56 per cent of the distant metastases. In decreasing order of frequency, +8, +7, and -Y were observed in the recurrences and +8, +7, -Y, and +1 in the distant metastases. Evaluation of the corresponding primary tumour tissue of the recurrence group showed numerical aberrations in 45 per cent of cases. The aberrations found were, in decreasing order of frequency, -Y, +7, and +8. In the concomitant primary tumour tissue of the distant metastasis group, numerical aberrations were detected in 67 per cent of cases. The aberrations most frequently encountered were +8, -Y, followed by +7. In four cases, a concordance was found between the primary tumour and its recurrence or distant metastasis. Discrepancies might have been caused by cytogenetic heterogeneity. Comparison of the primary tumour tissue of the reference, the recurrence, and the distant metastasis groups showed a significant increase for the percentage of cases with numerical aberrations (Ptrend = 0.02). Likewise, a trend was seen for gain of chromosome 7 and/or 8 (Ptrend < 0.05). The number of DNA aneuploid tumours also increased in these different groups (Ptrend = 0.03). These data suggest that cancers which recur in time display an intermediate position between tumours of disease-free patients and metastatic cancers.
Spotted Wilt Disease Evaluation Among High-Oleic Peanut Cultivars (2013)

The release of high-oleic, United States runner and virginia market type peanut (Arachis hypogaea L.) cultivars has been steadily increasing during the past several years. Two planting dates were utilized for disease evaluation and agronomic performance among these newer high-oleic cultivars. The first planting date test was in mid-April to allow for increased incidence of spotted wilt disease caused by Tomato spotted wilt virus (TSWV). The second planting date test was in mid-May to allow for less TSWV and provide more of an optimum time by comparison. Significant differences (P ≤ 0.05) were found within each of the three (3-year) averages among cultivars for TSWV and total disease (TD) incidence, pod yield, and dollar values. Among the virginia-types, Georgia Hi-O/L, Georgia-05E, and Georgia-08V, and runner-types, Georgia-02C and Georgia-09B, consistently had the lowest TSWV and TD incidence and the highest pod yield and dollar values in both the mid-April and mid-May planting date tests. No significant differences were found between the mid-April and the mid-May planting dates when averaged across this 5-year study for TSWV and TD incidence, pod yield, and dollar values. This suggests that the high-level of TSWV-resistance among these newer high-oleic cultivars should have a greater influence than planting dates on agronomic performance. Accepted for publication 8 June 2013. Published 12 August 2013.
Matrix infrared spectra and density functional calculations of transition metal hydrides and dihydrogen complexes (2004)

Metal hydrides are of considerable importance in chemical synthesis as intermediates in catalytic hydrogenation reactions. Transition metal atoms react with dihydrogen to produce metal dihydrides or dihydrogen complexes and these may be trapped in solid matrix samples for infrared spectroscopic study. The MH(2) or M(H(2)) molecules so formed react further to form higher MH(4), (H(2))MH(2), or M(H(2))(2), and MH(6), (H(2))(2)MH(2), or M(H(2))(3) hydrides or complexes depending on the metal. In this critical review these transition metal and dihydrogen reaction products are surveyed for Groups 3 though 12 and the contrasting behaviour in Groups 6 and 10 is discussed. Minimum energy structures and vibrational frequencies predicted by Density Functional Theory agree with the experimental results, strongly supporting the identification of novel binary transition metal hydride species, which the matrix-isolation method is well-suited to investigate. 104 references are cited.
Polymerase chain reaction assay for detection of human cytomegalovirus (1989)

Direct detection of human cytomegalovirus (HCMV) from clinical specimens was examined by using the polymerase chain reaction (PCR) for amplifying HCMV DNA. The efficiency of the amplification reaction was examined by using three different buffers and concentrations of deoxynucleotide triphosphates. The PCR assay was most efficient with a reaction mixture containing 17 mM ammonium sulfate, 67 mM Tris hydrochloride (pH 8.5), 7 mM MgCl2, 10 mM 2-mercaptoethanol, 170 micrograms of bovine serum albumin per ml, and each deoxynucleotide triphosphate at a final concentration of 1.5 mM. After 35 cycles of amplification, 0.15 fg of a plasmid containing the cloned target gene (corresponding to approximately six gene copies) was detected. The PCR assay correctly identified all of 24 clinical isolates of HCMV. Virus in urine specimens could be disrupted by heating at 93 degrees C for 30 min. The viral DNA was amplified directly from 5 microliters of preheated urine, with no further treatment before amplification. We tested the PCR assay on urine specimens from patients who had undergone renal transplantation that had been screened for the presence of HCMV by enzyme-linked immunosorbent assay, hybridization assay, and direct virus isolation. Specimens that were positive by one or more of these assays were screened by PCR. HCMV was consistently detected by PCR in all specimens that were positive by at least one other test. No cross-reactivity to other herpesviruses or MRC-5 cellular DNA was observed.
New tetrodotoxin analogs from the newt Cynops ensicauda (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew tetrodotoxin analogs from the newt Cynops ensicaudaTakeshi. Yasumoto, Mari. Yotsu, Michio. Murata, and Hideo. NaokiCite this: J. Am. Chem. Soc. 1988, 110, 7, 2344–2345Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/ja00215a078https://doi.org/10.1021/ja00215a078research-articleACS PublicationsRequest reuse permissionsArticle Views616Altmetric-Citations136LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multiple shape recognition using pairwise geometric histogram based algorithms (1995)

Pairwise geometric histogram (PGH) based algorithms have previously been shown to be a robust solution for the recognition of arbitrary 2D shapes in the presence of occlusion and scene clutter (Evans et al., 1993). The method is both statistically founded and complete in the sense that a shape may be reconstructed from its PGH representation (Riocreuz et al., 1994). The generality of this method has been further reinforced by an analysis of its scaleability which concludes that, if used appropriately, it is suitable for the recognition of very large numbers of objects (Ashbrook et al., 1995). The present authors demonstrate the application of PGHs to recognition tasks involving very large model training sets.
Intention Detection Based on Siamese Neural Network With Triplet Loss (2020)

Understanding the user's intention is an essential task for the spoken language understanding (SLU) module in the dialogue system, which further illustrates vital information for managing and generating future action and response. In this paper, we propose a triplet training framework based on the multiclass classification approach to conduct the training for the intention detection task. Precisely, we utilize a Siamese neural network architecture with metric learning to construct a robust and discriminative utterance feature embedding model. We modified the RMCNN model and fine-tuned BERT model as Siamese encoders to train utterance triplets from different semantic aspects. The triplet loss can effectively distinguish the details of two input data by learning a mapping from sequence utterances to a compact Euclidean space. After generating the mapping, the intention detection task can be easily implemented using standard techniques with pre-trained embeddings as feature vectors. Besides, we use the fusion strategy to enhance utterance feature representation in the downstream of intention detection task. We conduct experiments on several benchmark datasets of intention detection task: Snips dataset, ATIS dataset, Facebook multilingual task-oriented datasets, Daily Dialogue dataset, and MRDA dataset. The results illustrate that the proposed method can effectively improve the recognition performance of these datasets and achieves new state-of-the-art results on single-turn task-oriented datasets (Snips dataset, Facebook dataset), and a multi-turn dataset (Daily Dialogue dataset).
An advanced design system: design capture, functional test generation, mixed level simulation and logic synthesis [VLSI] (1989)

A VLSI CAD (computer-aided design) system has been enhanced by adding several tools. It consists of a mixed-level simulator, logic synthesis, layout systems, a functional test generation assistance, etc. The functional simulator, which is on a laptop PC, is for a 50 K-gate class LSI, and the mixed level simulator, which is on an EWS and a mainframe, is for above-100 K-gate VLSI. In-house designer groups have reported that the design time is cut in half using the system. A functional schematic capture provides a more friendly user interface than a logic schematic capture. A novel approach to functional test generation is also provided
Sequence Variation in the Herpes Simplex Virus U<sub>S</sub>1 Ocular Virulence Determinant (2011)

These results suggest that significant sequence variation exists in the U(S)1 gene, that the α22 protein contains a conserved central core region with structurally variable regions at the amino- and carboxyl termini, that 10 amino acids are conserved in α-herpes U(S)1 homologs, and that additional host proteins may interact with the HSV-1 U(S)1 and U(S)1.5 proteins. This information will be valuable in designing further studies on structure-function relationships and on the role these play in host-range determination and keratitis.