gebhart/patrepeval huggingface dataset:
Mechanism of Agrobacterium .beta.-glucosidase: kinetic analysis of the role of noncovalent enzyme/substrate interactions (1995)

The role of noncovalent interactions in the catalytic mechanism of the Agrobacterium faecalis beta-glucosidase was investigated by steady-state and pre-steady state kinetic analysis of the hydrolysis of a series of monosubstituted aryl glycosides, in which the hydroxyl groups on the glycone were substituted by hydrogen or fluorine. Contributions of each hydroxyl group to binding of these substrates at the ground state are relatively weak (interaction energies of 3.3 kJ/mol or smaller) but are much greater at the two transition states (glycosylation and deglycosylation). The strongest transition state interactions were at the 2 position (at least 18 and 22 kJ/mol for glycosylation and deglycosylation, respectively) with the interactions at the 3 and 6 positions contributing at least another 9 kJ/mol of binding energy at both transition states. The interaction at the 4 position is less crucial to transition state binding but important for stabilization of the glycosyl-enzyme intermediate. Comparison of observed rates with those for spontaneous hydrolysis of the same substrates provides evidence for oxocarbenium ion character at both transition states, that for deglycosylation apparently having the greater positive charge development at the anomeric center.
Meter for Sewer Flow Measurement (1975)

An experimental and analytical study was performed to develop the geometry for a Venturi type flow meter for use in sewer flow measurement. The meter consists of a constriction in the pipe which produces critical flow under open channel flow conditions and acts as a conventional Venturi meter under full flow conditions. The constriction is constructed using cylindrical segments the diameter of which are larger than that of the pipe, leaving the invert and crown clear. Head loss characteristics and experimental rating curves for both open channel and full flow conditions are described. Information is also presented to permit the selection of geometrical parameters for optimum performance for a specific installation.
INHIBITION OF TYROSINE HYDROXYLASE BY AQUAYAMYCIN (1968)

Aquayamycin was found to be a strong inhibitor of tyrosine hydroxylase. It inhibits tyrosine hydroxylase by 50 % at 3.7×10-7M. The inhibition is noncompetitive with tyrosine. The inhibition by 4×10-7 Maquayamycin increases when the concentration of 2-amino-4-hydroxy-6, 7-dimethyltetrahydropteridine is increased from 2×10-4M to 1×10-3M. The inhibition of tyrosine hydroxylase by aquayamycin is reversed by Fe++.
[Clinical observations with clarithromycin in pediatrics]. (1989)

Clarithromycin (TE-031, A-56268) was given orally to 25 children with acute bacterial infections including 5 with bronchitis, 8 with pneumonia, 4 with Mycoplasma pneumonia, 2 with pertussis and 6 with Campylobacter enteritis. Good to excellent clinical responses were obtained in 22 patients with bacterial eradication of all 10 strains. No side effect was observed. From the above clinical results, it appears that TE-031 is a useful antibiotic for the treatment of pediatrics with various bacterial infections.
Recommended Simple Security Capabilities in Customer Premises Equipment (CPE) for Providing Residential IPv6 Internet Service (2011)

This document makes specific recommendations to the makers of devices
that provide simple security capabilities at the perimeter of local-
area IPv6 networks in Internet-enabled homes and small offices.
Na+/H+ exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor (1994)

Activation of sarcolemmal Na+/H+ exchange has been proposed as a causal factor in reperfusion arrhythmogenesis. To test this hypothesis, we determined the antiarrhythmic efficacy of two structurally distinct but equipotent Na+H+ exchange inhibitors, 5-(N-ethyl-N-isopropyl)amiloride (EIPA) and the novel drug, 3-methylsulfonyl-4-piperidinobenzoyl guanidine (HOE-694), in isolated rat hearts (n = 12/group) subjected to independent dual coronary perfusion. After 15 min of aerobic perfusion of both beds, flow to the left coronary bed (LCB) was terminated for 10 min; this was followed by 5 min of reperfusion. Various concentrations of each drug were selectively infused into the LCB either during the 5-min period preceding ischemia plus during reperfusion or during reperfusion alone. With the former protocol, 0.01, 0.1, 1, and 10 microM EIPA reduced the incidence of reperfusion-induced ventricular fibrillation (VF) from 92% in controls to 83, 83, 50, and 0% (P < 0.05); the number of hearts in sinus rhythm at the end of reperfusion was increased from 17 to 42, 25, 83 (P < 0.05), and 100% (P < 0.05). HOE-694, at the same concentrations, reduced VF incidence from 92% in control to 83, 58, 50, and 8% (P < 0.05); 25, 67, 75 (P < 0.05), and 100% (P < 0.05) of hearts were in sinus rhythm, compared with 17% of controls, at the end of reperfusion. Even when infused during reperfusion alone, both drugs afforded significant protection against reperfusion-induced VF, which did not differ significantly from that observed when the drugs were also given before ischemia. The similar antiarrhythmic efficacy of EIPA and HOE-694 is consistent with an arrhythmogenic role for activation of Na+/H+ exchange during early reperfusion.
Atacama compact array antennas (2012)

The ACA (Atacama Compact Array) system is an important element of ALMA and consists of four ACA 12-m antennas and twelve ACA 7-m antennas. The ACA system aims to acquire the total power data with four 12-m antennas and the short baseline interferometer data with 7-m antennas. The ACA system also increases reliability of the interferometer maps of astronomical sources larger than the field view of the 12-m antenna. The science performance of these antennas has been extensively verified at OSF (operation support facility) at an elevation of 2900 m in Atacama desert in northern Chile since 2007. The pointing performance has been verified with a dedicated optical pointing telescope, the servo performance is tested with angle encoders, and the surface accuracy has been measured with a radio holography method. Both ACA 12-m antennas and 7-m antennas have been successfully demonstrated to meet the very stringent ALMA specifications.
<title>Lithography tricks and tribulations</title> (1996)

When considering optical lithography, there is no true substitute for the resolution enhancements afforded by a reduction in actinic radiation. However, as we move below 365 nm i-line systems, the optics and attendant materials considerations become acute. Additionally, there is an obvious economic impetus to breath new life into existing exposure systems. Various optical enhancement schemes have been developed over the past few years for these and other reasons. While many of these are well suited for the patterns and economics of memories, there are a few that enable sub 0.5 kl ASIC imaging. These include: large NA, optical proximity correction, and the deployment of sub- resolution assist features. We will demonstrate a blend of these that will support 280 nm ASIC pattern delineation with i-line (365 nm) systems and binary (non-phase-shift) masks.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Using a dog's superior olfactory sensitivity to identify Clostridium difficile in stools and patients: proof of principle study (2012)

A trained dog was able to detect C difficile with high estimated sensitivity and specificity, both in stool samples and in hospital patients infected with C difficile.
Is Cardioprotection Dead? (2017)

For >4 decades, the holy grail in the treatment of acute myocardial infarction has been the mitigation of lethal injury. Despite promising initial results and decades of investigation by the cardiology research community, the only treatment with proven efficacy is early reperfusion of the occluded coronary artery. The remarkable record of failure has led us and others to wonder if cardioprotection is dead. The path to translation, like the ascent to Everest, is certainly littered with corpses. We do, however, highlight a therapeutic principle that provides a glimmer of hope: cellular postconditioning. Administration of cardiosphere-derived cells after reperfusion limits infarct size measured acutely, while providing long-term structural and functional benefits. The recognition that cell therapy may be cardioprotective, and not just regenerative, merits further exploration before we abandon the pursuit entirely.
Effect Of Different Methods Of Soil Fertility On Grain Yield And Chickpea Quality (2010)

In order to evaluation the effects of natural, biological and chemical fertilizers on grain yield and chickpea quality, field experiments were carried out in 2007 and 2008 growing seasons. In this research the effects of different organic, chemical and biological fertilizers were investigated on grain yield and quality of chickpea. Experimental units were arranged in split-split plots based on randomized complete blocks with three replications. The highest amounts of yield and yield components were obtained in G1×N5 interaction. Significant increasing of N, P, K, Fe and Mg content in leaves and grains emphasized on superiority of mentioned treatment because each one of these nutrients has an approved role in chlorophyll synthesis and photosynthesis ability of the crop. The combined application of compost, farmyard manure and chemical phosphorus (N5) had the best grain quality due to high protein, starch and total sugar contents, low crude fiber and reduced cooking time.
Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells. (1987)

Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems. Because of its potential clinical application, we evaluated the ability of verapamil to modulate the effect of ADR and vinblastine on the in vitro cloning of fresh human tumor cells. Fifty-three tumors were cloned in a soft agar system. Continuous exposure to verapamil at concentrations of 1.0, 5.0, and 10.0 micrograms/ml, did not significantly modulate the overall inhibitory activity of ADR and vinblastine (P greater than 0.05). There was no evidence of an effect when results were analyzed by tumor type or previous treatment except in the subgroup of 13 tumors obtained from patients who previously had a clinical response to ADR but were relapsing at the time the tumor specimen was obtained. In this population, at three concentrations of ADR, there was a significant modulation of drug effect (P = 0.10, 0.03, 0.03, respectively). In each subgroup, some tumors showed marked modulation of drug effect by verapamil. These results suggest that the mechanisms of acquired in vivo resistance to ADR may be similar to those occurring in cell lines. However, the effect on human tumors was minor as compared to the results with cell lines. The in vivo significance of this finding remains to be determined.
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma (2018)

(Cancer Cell 32, 204–220; August 14, 2017) During the course of revising the manuscript, the authors inadvertently did not include the reference to a paper by Royer-Bertrand et al. in the reference list as well as the corresponding citation in the discussion of copy number variants in uveal melanoma and their consistency in high-risk primary and metastatic tumors. Royer-Bertrand et al. should have been cited in the second paragraph under the Discussion section as follows: “Prior studies have shown poorer clinical outcomes to be associated with higher chromosome 8q copy number (Royer-Bertrand et al., 2016Royer-Bertrand B. Torsello M. Rimoldi D. El Zaoui I. Cisarova K. Pescini-Gobert R. Raynaud F. Zografos L. Schalenbourg A. Speiser D. et al.Comprehensive genetic landscape of uveal melanoma by whole-genome sequencing.Am. J. Hum. Genet. 2016; 99: 1190-1198Abstract Full Text Full Text PDF PubMed Scopus (107) Google Scholar; Caines et al., 2015; Cassoux et al., 2014; Versluis et al., 2015).” The reference is now included below and has been added to the online version of the article, along with the citation. The authors apologize for the omission and any confusion it may have caused. Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal MelanomaRobertson et al.Cancer CellAugust 14, 2017In BriefRobertson et al. analyze 80 uveal melanomas (UM) and divide poor-prognosis monosomy 3 UM into subsets with divergent genomic aberrations, transcriptional features, and clinical outcomes. Somatic copy number changes and DNA methylation profiles separate better-prognosis disomy 3 UM into low or intermediate risk. Full-Text PDF Open Access
The effect of gold(<scp>i</scp>) coordination on the dual fluorescence of 4-(dimethylamino)pyridine (2015)

The reactions of 4(dimethylamino)pyridine (DMAP) with the gold(I) precursors [AuR(tht)] (R = C6F5, C6Cl2F3 or C6Cl5; tht = tetrahydrothiophene) lead to complexes [AuR(DMAP)] (R = C6F5 (1), C6Cl2F3 (2) or C6Cl5 (3)). X-ray diffraction studies of the complexes reveal the presence of discrete molecules in which aurophilic contacts are absent, with π-stacking (1) or hydrogen bond (2) interactions being responsible for the supramolecular arrangements found in the solid state. All complexes display fluorescence in solution in solvents of different polarities such as toluene, chloroform or acetonitrile. In all cases the emission energy is similar to the low-energy Twisted Intramolecular Charge Transfer (TICT) emission of free DMAP. TDDFT calculations confirm that the fluorescence of complexes 1-3 arises from the ICT excited state of bonded DMAP in which a 90° distortion of the pyridine ring and -NMe2 planes is observed. Model calculations based on experimental parameters show a higher degree of polarization of DMAP upon coordination to Au(I) organometallic fragments.
The effect of adjuvants on the efficacy of a recombinant herpes simplex virus glycoprotein vaccine. (1988)

A recombinant, truncated HSV type 1 glycoprotein D secreted by Chinese hamster ovary cells (rgD1) was used to compare the ability of several adjuvants to stimulate protective immunity in guinea pigs. Adjuvants tested included CFA, aluminum hydroxide (alum), a lipophilic derivative of muramyl tripeptide (MTP-PE), and a muramyl dipeptide (MDP) covalently conjugated to rgD1. Animals were immunized three times with rgD1 plus the various adjuvants and antibody titers were determined by ELISA. Four weeks after the last immunization, the animals were challenged intravaginally with HSV type 2 and were monitored daily for clinical signs of disease, including frequency and severity of herpetic lesions, incidence of urinary retention, and mortality during the 14-day post-challenge observation period. Animals immunized in the foot-pad with rgD1 formulated with CFA showed the highest antibody titers. Animals immunized in the footpad with rgD1 using MTP-PE in a 4% squalene formulation, alum, or rgD1 conjugated to MDP showed mean antibody titers that were 57, 16, and 13% of the CFA titers, respectively. Immunization with rgD1 plus MTP-PE, alum, or rgD1-MDP conjugate by the i.m. route elicited lower antibody titers than the footpad route of immunization. Results of the viral challenge indicated that clinical symptoms of the groups immunized with rgD1 with CFA or MTP-PE as adjuvant were similar in magnitude and were markedly reduced compared with unimmunized control groups. Animals immunized with rgD1 combined with alum or rgD1-MDP conjugate showed clinical symptoms significantly more severe than the CFA or MTP-PE groups. The protective immunity observed after i.m. immunization of animals with rgD1 and MTP-PE was only slightly lower than animals immunized with the same Ag-adjuvant combination in the footpad. The results indicate that MTP-PE is an effective adjuvant for the recombinant herpes gD vaccine.
Restoration of images of finite extent objects by a singular value decomposition technique (1982)

Extrapolation of the Fourier spectrum of an object of finite extent is treated as an algebraic restoration problem. Available samples of the spectrum or the image are modeled as arising due to a matrix transformation of the vector representing the object or the extrapolated part of the spectrum. A singular value decomposition of the matrix transformation is used to obtain a minimum norm estimate for the object. Simulation results for 1-D objects are presented.
Real or Spiel? A Decision Tree Approach for Automated Detection of Deceptive Language-Action Cues (2016)

As the use of computer-mediated communications has increased, the potential risk of online deception has grown -- as has the importance of better understanding human behavior online to mitigate these risks. Previous research has demonstrated that linguistic features provide crucial cues to detect deception, and that reasonable accuracy in detection of deception can be achieved by applying certain classification methodologies to these cues. This paper expands on this line of inquiry, and presents findings from a study conducted in the Spring of 2015. Our findings suggest a viable process for and the feasibility of using a decision-tree classification approach to develop an automated process to detect deception in computer-mediated communications.
High temperature metal atom beam sources (1995)

This paper presents a survey of the factors governing the performance and operation of high temperature subsupersonic metal atom beam sources. After an initial statement of the requirements placed on such sources a section is presented which considers the factors determining atomic beam intensities and profiles. The section which considers the materials used in source construction discusses the choice of crucible material, and in so doing presents a table of the most suitable materials, hazard assessments, and other information for all those elements which can be vaporized. Two further parts of this section are devoted to resistive heater materials and ceramics. The review of the sources is divided between resistively heated sources, sources heated by electron bombardment, and inductively heated sources. Finally there is a section which briefly discusses the monitoring of source performance.
Long-term experience with cesium beam frequency standards (2003)

Since its introduction 7 years ago, the Hewlett-Packard cesium beam frequency standard has been installed in many national laboratories. At the present, this standard represents over 70% of the number of atomic clocks reported to the Bureau International des Poids et Mesures (BIPM). Many of these are monitored on a continuous basis. Data from 160 clocks HP currently reported by BIPM is used to estimate overall frequency accuracy. Data taken at the United States Naval Observatory (USNO) on a daily basis for a period of years for in excess of 40 clocks gives a reasonably clear picture of overall life expectancy and day-to-day performance variations. For example, instances of anomalous beam current performance, which causes a premature instrument shutdown, have been observed. Data from the National Institute of Standards and Technology (NIST) gives an unbroken string of frequency deviations for over 1500 days on two clocks, and lesser time span for two other clocks. This allows an estimate of the upper limit of a frequency stability flicker floor. The accumulated data also gives further insight into cesium beam tube end-of-life behavior. Production, test, and verification data is taken routinely on every clock in the manufacturing process. The database now contains data on well over 1000 clocks. A recent analysis of data from all sources has highlighted actual clock performance in a variety of environments. The details of the analysis and the results obtained form the core of the paper.
PERSONAL SAFETY TRIGGERING SYSTEM ON ANDROID MOBILE PLATFORM (2012)

Introduction of Smart phones redefined the usage of mobile phones in the communication world. Smart phones are equipped with various sophisticated features such as Wi-Fi, GPS navigation, high resolution camera, touch screen with broadband access which helps the mobile phone users to keep in touch with the modern world. Many of these features are primarily integrated with the mobile operating system which is out of reach to public, by which the users can’t manipulate those features. Google came up with an innovative operation system termed as ANDROID, which is open system architecture with customizable third party development and debugging environment which helps the user’s to manipulate the features and to create their own customizable applications. In this paper, ‘Emergency Based Remote Collateral Tracking System’ application using Google’s Android Mobile Platform is addressed. Emergency is divided into three categories: heart beat based emergency, security threats like personal safety and road accidents. This application is targeted to a person who is driving a vehicle. Heart rate monitoring device is integrated with our application to sense the heart beat of a person driving the vehicle and if there is any abnormalities in the heart beat, then our application performs a dual role. One in which, application uses a GPS to track the location information of the user and send those location information as a message via SMS, email and post it on Facebook wall Simultaneously, an emergency signal is sent to Arduino Microcontroller. Road accidents are quite common, this application is also designed to detect the accident using the sensors in the Android Mobile. Security threat can occur anywhere, our application also answers for personal safety, when the user interacts with the application by pressing the button, then automatically the application generates the geographical information and sends that location information via SMS and email to a pre-stored emergency contact and the same information will be posted on user’s Facebook wall. This application is written in JAVA programming language which runs on Eclipse Integrated Development Kit.
Sodium-level-sensitive Sodium Channel and Salt-Intake Behavior (2005)

Mammals feel thirsty or develop an appetite for salt when the correct balance between water and sodium in the body fluid has been disrupted, but little is known about the mechanism in the brain that controls salt homeostasis. It has been postulated that the existence of both an osmoreceptor and a specific sodium receptor is required to accommodate the experimental data (Johnson and Edwards, 1990; Denton et al., 1996). Several candidate osmoreceptors have been reported (Oliet and Bourque, 1993; Wells, 1998; Liedtke et al., 2000); however, a specific sodium receptor has not been identified. The Nax channel—formerly called NaG/SCL11 (in rats), Nav2.3 (in mice) and Nav2.1 (in humans)—has been classified as a subfamily of voltage-gated sodium channels (Goldin et al., 2000). The primary structure of Nax, however, markedly differs from that of other voltage-gated sodium channel family members and includes differences in the key regions for voltage sensing and inactivation. The functional properties of the channel are poorly understood, as all attempts to induce functional expression of Nax in heterologous systems have failed. Several years ago, we generated mice in which the Nax gene was knocked-out by insertion of the lacZ gene in-frame and found that the Nax channel is expressed in cells in the circumventricular organs (CVOs) (Watanabe et al., 2000), in particular the subfornical organ (SFO) and organum vasculosum lamina terminalis (OVLT), which are important regions for the control of body fluid ionic balance; for the expression other than the CNS (see Watanabe et al., 2002). Under thirst conditions, Nax-deficient mice showed hyperactivity of the neurons in these two areas and ingested excessive salt: Wild-type mice take water and stop salt ingestion under dehydrated condition. Infusion of a hypertonic Na solution into the cerebral ventricle also induced extensive water intake and aversion to saline (0.3 M