gebhart/patrepeval huggingface dataset:
Transforming Growth Factor β Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17 (2008)

Overexpression of the immunosuppressive cytokine transforming growth factor beta (TGF-beta) is one strategy that tumors have developed to evade effective immunesurveillance. Using transplantable models of breast and colon cancer, we made the unexpected finding that CD8+ cells in tumor-bearing animals can directly promote tumorigenesis, by a mechanism that is dependent on TGF-beta. We showed that CD8+ splenocytes from tumor-bearing mice expressed elevated interleukin (IL)-17 when compared with naive mice, and that CD8+ T cells could be induced to make IL-17 on addition of TGF-beta and IL-6 in vitro. Treatment of mice with anti-TGF-beta antibodies in vivo reduced IL-17 expression both in the tumor and the locoregional lymph nodes. Although IL-17 has not previously been shown to act as a survival factor for epithelial cells, we found that IL-17 suppressed apoptosis of several tumor cell lines in vitro, suggesting that this altered T-cell polarization has the potential to promote tumorigenesis directly, rather than indirectly through inflammatory sequelae. Consistent with this hypothesis, knockdown of the IL-17 receptor in 4T1 mouse mammary cancer cells enhanced apoptosis and decreased tumor growth in vivo. Thus, in addition to suppressing immune surveillance, tumor-induced TGF-beta may actively subvert the CD8+ arm of the immune system into directly promoting tumor growth by an IL-17-dependent mechanism.
Bringing civility in governance (2003)

This handbook series comprises six volumes: The first volume focused on incentives that insure accountability of the public sector, measuring government performance in the delivery of public services, addressing social issues in government decision making, improving governance through better policy and expenditure evaluations, principles and practices of intergovernmental fiscal relations, and harmonizing fiscal decentralization with regional disparities and fiscal constraints.
The National Ignition Facility Project. Revision 1 (1994)

The mission of the National Ignition Facility is to achieve ignition and gain in inertial confinement fusion targets in the laboratory. The facility will be used for defense applications such as weapons physics and weapons effects testing, and for civilian applications such as fusion energy development and fundamental studies of matter at high temperatures and densities. This paper reviews the design, schedule, and costs associated with the construction project.
Signal Processing with Charge-Coupled Devices (1978)

The purpose of this paper is to discuss applications of charge-coupled devices in signal processing systems. Both analog and digital CCD concepts are considered. Recent developments in high-speed (~100 MHz) CCD's are discussed, and the uses of high-speed CCD and surface-acoustic wave (SAW) devices together are considered. Examples of the applications of CCD's in electro-optical systems, secure voice communication systems, sonar systems and radar systems are given. Finally, projections for future uses of CCD's in signal processing systems are presented.
Is Digital Health Intervention Effective in Inflammatory Bowel Disease Patients? (2021)

Technological advances now permit self-management strategies using mobile applications which could greatly benefit patient care. The purpose of this study was to investigate whether the use of the inflammatory bowel disease (IBD) digital health monitoring platform, HealthPROMISE, leads to better quality of care and improved health outcomes in IBD patients. IBD patients were recruited in gastroenterology clinics and asked to install the HealthPROMISE application onto their smartphones. Patient satisfaction, quality of care, quality of life, patient symptoms, and resource utilization metrics were collected throughout the study and sent directly to their healthcare teams. Patients with abnormal symptom/SIBDQ scores were flagged for their physicians to follow up. After one-year, patient outcome metrics were compared to baseline values. Overall, out of 59 patients enrolled in the study, 32 patients (54%) logged into the application at least once during the study period. The number of IBD-related ER visits/hospitalizations in the year of use compared to the prior year demonstrated a significant decrease from 25% of patients (8/32) to 3% (1/32) (p = 0.03). Patients also reported an increase in their understanding of the nature/causes of their condition after using the application (p = 0.026). No significant changes were observed in the number of quality indicators met (p = 0.67) or in SIBDQ scores (p = 0.48). Given the significant burden of IBD, there is a need to develop effective management strategies. This study demonstrated that digital health monitoring platforms may aid in reducing the number of ER visits and hospitalizations in IBD patients.
Water–fat MRI for assessing changes in bone marrow composition due to radiation and chemotherapy in gynecologic cancer patients (2013)

Water-fat MRI is sensitive to changes in red/yellow marrow composition, and can be used for quantitative and qualitative assessment of treatment-induced marrow damage.
Hemodynamic Improvement after Oral Hydralazine in Left Ventricular Failure (1977)

Hydralazine was administered in a single oral dose of 50 to 100 mg in 16 patients with left ventricular failure due to cardiomyopathy. It produced sustained effects for at least 4 h characterized by a significant increase in cardiac output, a reduction in arterial and pulmonary arterial pressure, and a slight rise in heart rate. When compared to nitroprusside infusion in these same patients, hydralazine produced a similar reduction in systemic vascular resistance but a slightly greater increase in cardiac index (0.74 versus 0.95 litres/min-m2), with a lesser fall in mean arterial pressure (7.8 versus 13.6 mm Hg, P less than 0.01), mean pulmonary arterial pressure (4.2 versus 11.3 mm Hg, P less than 0.001), and pulmonary wedge pressure (5.5 versus 9.9 mm Hg, P less than 0.001). Forearm venous tone decreased and venous compliance increased during nitroprusside infusion, but they were unchanged after hydralazine therapy. These data suggest that hydralazine may be a useful agent in the treatment of chronic left ventricular failure.
The Transition from the Continental Congress to the Congress of the Confederation (1932)

Research Article| June 01 1932 The Transition from the Continental Congress to the Congress of the Confederation Frank Harmon Garver Frank Harmon Garver Search for other works by this author on: This Site PubMed Google Scholar Pacific Historical Review (1932) 1 (2): 221–234. https://doi.org/10.2307/3633693 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Frank Harmon Garver; The Transition from the Continental Congress to the Congress of the Confederation. Pacific Historical Review 1 June 1932; 1 (2): 221–234. doi: https://doi.org/10.2307/3633693 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentPacific Historical Review Search This content is only available via PDF. Copyright 1932 The Arthur H. Clark Company Article PDF first page preview Close Modal You do not currently have access to this content.
Controlled Atmosphere and Antioxidant Effects on External CO2 Injury of `Empire' Apples (1997)

The histology of external CO 2 injury of the skin of `Empire' apples and postharvest factors affecting occurrence of injury were investigated. Injury was greater in a 5% CO 2 /2% O 2 atmosphere than in 2% CO 2 /2% O 2 , but incidence was affected by orchard source. Susceptibility to injury was highest during the first 4 weeks of storage, while a postharvest treatment with diphenylamine prevented the disorder. Ethanol reduced injury, but ascorbic acid increased incidence of the disorder. Keeping fruit in air cold storage for 10 days before application of CO 2 markedly reduced incidence of CO 2 injury. Histological studies showed that external CO 2 injury begins at the hypodermis—cortex boundary and spreads outward into the upper hypodermis and inward into outer cortex cells, although the cuticle and epidermis appear unaffected and unbroken. Radial walls of affected cells collapse and become pleated, so that the skin surface sinks below nearby normal regions. Other cellular events include loss of cytoplasmic integrity, coagulation of the protoplast, loss of organelle structure, and cell wall separation. Nondigested starch can be found in cells of affected fruit at the hypodermis—cortex boundary. We conclude that several factors affect fruit susceptibility to CO 2 injury, including orchard, antioxidant treatment, and delays before application of CO 2 .
Atom-Based Vector Microwave Electrometry Using Rubidium Rydberg Atoms in a Vapor Cell (2013)

It is clearly important to pursue atomic standards for quantities like electromagnetic fields, time, length, and gravity. We have recently shown using Rydberg states that Rb atoms in a vapor cell can serve as a practical, compact standard for microwave electric field strength. Here we demonstrate for the first time that Rb atoms excited in a vapor cell can also be used for vector microwave electrometry by using Rydberg-atom electromagnetically induced transparency. We describe the measurements necessary to obtain an arbitrary microwave electric field polarization at a resolution of 0.5°. We compare the experiments to theory and find them to be in excellent agreement.
A framework for object-oriented fuzzy expert systems (2002)

In recent years, the fuzzy logic has been widely used in the field of AI. Many successful fuzzy expert systems and fuzzy control systems have been developed. In general, these systems adopt the rule-based knowledge representation. On the other hand, it is also suitable to adopt the object-oriented paradigm for representing knowledge. This paper proposes a framework that integrates the fuzzy inference model and the object-oriented paradigm for building expert systems. This framework embeds the properties of object-oriented paradigm, e.g., encapsulation, inheritance, message passing and polymorphism, into the model of fuzzy expert systems. It also includes a partial inheritance model, so that the child object may inherits the property of parent object partially. The inheritance process is viewed as a process of evolution, and the partial inheritance is treated as a special kind of fuzzy implication.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Study of Gas‐Liquid Two‐Phase Flow in a Horizontal Tube Under Microgravity (2002)

A better understanding of the effect of gravity level on two-phase flow characteristics is crucial for designing two-phase heat transport systems and thermal control systems for space. Hence, an experiment was conducted aboard MU-300 aircraft, as well as at normal gravity using the same horizontal tube, 10mm internal diameter and flow conditions. The experimental results, obtained under Earth, hypergravity (2g), and microgravity environments were compared with previous models. Flow pattern data were compared with data from models for predicting microgravity flow pattern transitions. The mean void fraction under microg and 1g conditions was also compared with the Inoue-Aoki model for vertical upward annular flow at normal gravity. Frictional pressure drop fitted well with the Lockhart-Martinelli model, slightly influenced by the change in gravity levels (microg, 1g, and 2g); however, the effect of changing gravity on the pressure drop was insignificant for turbulent flow.
Detecting ventricular fibrillation (1995)

The short time Fourier transform (STFT), smoothed pseudo Wigner Ville distribution (SPWVD), and cone-shaped kernel distribution (CKD) have been used to compare the time-frequency distribution of normal sinus rhythm, ventricular tachycardia, ventricular flutter, and ventricular fibrillation signals. This work is a pilot study to illustrate that the CKD and SPWVD have better time and frequency resolution than the STFT. It demonstrates that accurate methods of computing the time-frequency domain should be found for ECG signals. Only then should future work be done to design discriminatory features and classifiers for arrhythmias.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Battery-free Wireless Communication for Video Capsule Endoscopy (2019)

Wireless capsule endoscopy is an advanced application of using ICT in healthcare and medicine. It is a non-invasive method to examine the gastrointestinal (GI) for early diagnosis and treatment. The capsule is equipped with a camera, light source, processing, control unit, and a transmitter to send the captured pictures or videos wirelessly to an external receiver system. The capsule is used to monitor small bowel diseases, esophageal diseases, and colonic diseases. The current data rate of the capsule endoscopes is limited to 1-2 Mbps with 2-3 frames per second and significant compression rates are applied to provide an operation time at least 8 hours inside the body. The data and frame rates might be sufficient for a capsule without locomotion, in which the capsule travels slowly, and the gastric wall movements mainly manage the speed. However, the next generation of the capsules will need remote locomotion and orientation control for fast and precise diagnosis. This application requests high data rate and low image or video compression rates with high frame rates for real-time navigation and control. Such a communication system becomes power hungry and limits the longevity of the device. Design of an ultra-low power wireless transmission scheme can assist the capsule device to save energy to handle the technology requirements. In this paper, we assess the communication systems of the capsule endoscopes and propose a battery-free high data rate backscatter wireless transmission scheme. The proposed system has been tested inside biological phantom in order to measure the path loss over different capsule depths. The average attenuation in a backscatter link inside biological phantom is 4.1 dB/cm in which is a linear function of capsule depth. According to link budget calculations, by using a 20 dBm transmitter at the outside of the body we can receive 8 Mbps data from the capsule at 10 cm depth. Our proposed system demonstrates superior performance compared to state-of-the-art systems in the literature.
Supercritical CO<sub>2</sub>-Based Formation of Silica Nanoparticles Using Water-in-Oil Microemulsions (2003)

A novel method is proposed for the precipitation of silica nanoparticles using supercritical CO2, in which supercritical CO2 acts both as the antisolvent and as a reactant. A water-in-oil microemulsion of an aqueous sodium silicate solution in n-heptane or isooctane is injected into supercritical CO2 by means of a micronozzle, forming small droplets. Supercritical CO2 rapidly extracts the solvent from the droplets and reacts with the exposed surfactant-supported aqueous sodium silicate reverse micelles, forming silica nanoparticles sodium carbonate, byproduct and water. The precipitated silica nanoparticles are washed with water and the surfactant and sodium carbonate free particles are obtained using ultrafiltration. Process parameters affecting silica nanoparticle size such as water and surfactant concentrations, the type of solvent used in the microemulsion, and the CO2 pressure are investigated. Microstructure and size analyses of the precipitated silica nanoparticles are carried out using transmission electron microscopy and dynamic light scattering. The proposed method is demonstrated by the precipitation of silica nanoparticles having sizes in the range of 20−800 nm.
Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies (2016)

Lassa fever is a significant health threat to West African human populations with hundreds of thousands of annual cases. There are no approved medical countermeasures currently available. Compassionate use of the antiviral drug ribavirin or transfusion of convalescent serum has resulted in mixed success depending on when administered or the donor source, respectively. We previously identified several recombinant human monoclonal antibodies targeting the glycoprotein of Lassa virus with strong neutralization profiles in vitro. Here, we demonstrate remarkable therapeutic efficacy using first-in-class human antibodies in a guinea pig model of Lassa infection thereby presenting a promising treatment alternative.
Lamellarins O and P: New Aromatic Metabolites From the Australian Marine Sponge <i>Dendrilla cactos</i> (1994)

A specimen of Dendrilla cactos collected during trawling operations in Bass Strait, Australia, has yielded two new alkaloids, lamellarin-O (17) and lamellarin-P (18). Both these metabolites are examples of the lamellarin structure class, previously reported from tunicates and a mollusc; however, in these examples the pyrrole ring system is not fused to adjacent aromatic rings. The structures of (17) and (18) were secured by spectroscopic analysis and partial synthesis.
Synthesis and characterization of indolocarbazole-quinoxalines with flat rigid structure for sensing fluoride and acetate anions (2008)

A new series of indolocarbazole-quinoxalines (ICQ, receptors 6 and 7) are prepared and characterized for effective fluoride and acetate anion sensing. The new indole-based system has a highly flat rigid structure with a large pi system, and exhibits high binding affinity and sensitivity for acetate and fluoride anions. Receptors 6 and 7 give abundant and unique spectral features in dimethyl sulfoxide (DMSO). Both fluoride and acetate anions cause a bathochromic shift of the absorption peaks of receptor 7 in DMSO, whereas only fluoride anion results in a remarkable shift of the absorption peak of receptor 6 in DMSO. Receptors 6 and 7 can also operate as efficient colorimetric sensors for naked-eye detection of fluoride and acetate anions, and their combined use also offers a simple way for distinguishing these two anions by the naked-eye. The analysis of a Job's plot for the binding of receptor 7 and F(-), single crystal structures of 7.TBACl and 7.TBACH(3)COO confirm 1:1 binding stoichiometry. Notably, the ICQ system offers novel and excellent receptors for acetate anion both in solution and in crystalline solid through the formation of two hydrogen bonds.
Frequent expression of Bcl-2 in renal-cell carcinomas carrying wild-type p53 (1996)

The p53 tumor-suppressor gene is the most commonly mutated gene in cancer. However, p53 gene alterations are infrequent in renal-cell cancer (RCC). Bcl-2 has been shown to inhibit apoptosis triggered by wild-type p53 and an inverse correlation between Bcl-2 expression and p53 mutation has been observed in breast cancer and glioma. To characterize the expression of bcl-2 in RCC and its relationship to the p53 status, we analyzed 25 RCCs by immunohistochemistry for Bcl-2 and p53, Southern hybridization for bcl-2, and PCR-SSCP and sequencing for p53. Positive Bcl-2 staining was detected in 17 of 25 RCCs, whereas positive p53 staining was seen in only 1. Amplification of bcl-2 or p53 mutation was not detected in any of the tumors. Bcl-2 protein was expressed in all 7 RCC cell lines examined. Only one of the 7 lines had p53 mutation. These results suggest that overexpression of bcl-2, rather than p53 mutation, may prevent apoptosis during RCC development.
Mechanisms for the operation of thin film transistors on ferroelectrics (1995)

Abstract The electric field emanating from the surface of a poled ferroelectric can control the conduction properties of an overlying semiconducting film; this combination of materials can thus serve as a non-destructive readout, non-volatile memory device. Here we will describe a variety of experimental studies of these devices designed to probe the physics of their operation. The experimental systems included sputtered, n-type semiconductor (SC) films of In2O3 and ZnO deposited on bulk PLZT ferroelectrics (FE) and thin PZT FE films. Two distinctly different types of device response were measured in this study; in the first, the change in SC film conductance observed in the remanent FE state is in the direction expected from the remanent polarization vector in the ferroelectric. In the second, typically seen in thin film FE devices, the opposite behavior is observed. We find that these two general cases of behavior, including the observed variations of the SC film conductances and carrier mobilities, can be described by a general model which takes into account not only the FE displacement vector, but also charge injected from the semiconductor into the ferroelectric during biasing of the gate.
Instruction level profiling and evaluation of the IBM/6000 (1991)

results from using goblin, a new instruction level profiling system, to evaluate the IBM RISC System/6000 architecture.
Monitoring data visualization and agent-based software management for the Grid (2005)

In this paper, we present our results in the areas of monitoring data visualization and software management for the Grid.
5-Substituted isophthalate-based organic electrochromic materials (2008)

A new series of isophthalate-based electrochromic materials were prepared. The functional groups at the 5-position of isophthalate have a significant influence on the observed color. In particular, an electrochemically active nitro group induced a multi-color display, indicating that further electrochromic properties could be manipulated using more diverse 5-substituted isophthalate derivatives.
Studies on Phenylketonuria (1957)

Phenylketonuria is a condition in which there is an inherited biochemical defect in the normal oxidation of phenylalanine to tyrosine. This abnormality was first recognized and described by Fölling<sup>1</sup>in 1934; the term phenylketonuria, suggested by Penrose and Quastel,<sup>2</sup>has been used by many recent investigators. Extensive clinical reports<sup>3-8</sup>and further chemical investigations of urine,<sup>9-13</sup>blood,<sup>4,5,7,11-18</sup>spinal fluid,<sup>14</sup>and brain<sup>19,20</sup>have been published subsequently. Persons with this defect are almost always mentally retarded, usually to a severe degree. Most authors make no comment, or only incidental mention, of seizures in patients with phenylketonuria, but Cowie,<sup>16</sup>Woolf and Vulliamy,<sup>4</sup>and Bosma and associates<sup>8</sup>have commented upon the frequency of coincident epilepsy. Penrose<sup>21</sup>mentioned in 1946 that some affected children had seizures but that he had never observed them in phenylketonuric adults. The incidence of this disease in the population at
Accelerating the cloud with heterogeneous computing (2011)

Heterogeneous multiprocessors that combine multiple CPUs and GPUs on a single die are posed to become commonplace in the market. As seen recently from the high performance computing community, leveraging a GPU can yield performance increases of several orders of magnitude. We propose using GPU acceleration to greatly speed up cloud management tasks in VMMs. This is only becoming possible now that the GPU is moving on-chip, since the latency across the PCIe bus was too great to make fast, informed decisions about the state of a system at any given point. We explore various examples of cloud management tasks that can greatly benefit from GPU acceleration. We also tackle tough questions of how to manage this hardware in a multi-tenant system. Finally, we present a case study that explores a common cloud operation, memory deduplication, and show that GPU acceleration can improve the performance of its hashing component by a factor of over 80.