gebhart/patrepeval huggingface dataset:
CONSTRUÇÃO COLETIVA: PROPOSTA DE CAPACITAÇÃO EM QUIMIOTERAPIA (2018)

O Ministério da Saúde (MS), através da Política Nacional de Educação Permanente em Saúde (BRASIL, 2007), propõe a estratégia de mudança das práticas de formação, atenção e gestão na saúde. Guiada por esta política pública e buscando atender como rede de apoio às necessidades de conhecimentos sobre a diversidade de tratamentos e protocolos antineoplásicos, surgiu em 2016, a consultoria de Enfermagem Oncológica - Quimioterapia, realizada pelas enfermeiras do ambulatório de quimioterapia do HCPA para as unidades de internação. O objetivo deste estudo foi avaliar as consultorias realizadas por este serviço desde sua criação, propondo uma ação educativa a partir dos dados encontrados no mesmo. Trata-se de um estudo de caráter exploratório-descritivo, onde se realizou uma análise dos dados retrospectivos das consultorias de Enfermagem Oncológica – Quimioterapia, desde sua criação até maio de 2018, completando dois anos de coleta. O estudo foi submetido e aprovado pelo Comitê de Ética em Pesquisa do HCPA. Nos dois anos de funcionamento deste serviço foram realizadas 92 solicitações de consultoria, 91% destas foram atendidas e 8% foram repetidas ou erradas. O tempo de resposta em 78% dos casos ocorreu em até 3h. Os principais motivos de requisição das consultorias foram: ordem infusional (66%), orientação de cuidados (18%) e punção de portocath (12%). As condutas realizadas foram: orientações através do computador (64%), presenciais na unidade de internação (22%) e através do telefone (14%). As especialidades que se destacaram foram: a Oncologia (63%) e da Hematologia (25%). A partir dos dados encontrados foi construída uma proposta de ação educativa para suprir as necessidades encontradas através dos principais motivos de solicitação de consultoria. Observou-se uma progressão de conhecimentos após a aplicação do instrumento de avaliação da ação. O presente estudo espera contribuir na análise de que uma ação de educação permanente em saúde neste contexto potencializa o serviço prestado quando aplicado de forma contínua e dialógica.
mTORC1 Signaling Can Regulate Growth Factor Activation of p44/42 Mitogen-activated Protein Kinases through Protein Phosphatase 2A (2007)

The mTORC1 complex (mammalian target of rapamycin (mTOR)-raptor) is modulated by mitogen-activated protein (p44/42 MAP) kinases (p44/42) through phosphorylation and inactivation of the tuberous sclerosis complex. However, a role for mTORC1 signaling in modulating activation of p44/42 has not been reported. We show that in two cancer cell lines regulation of the p44/42 MAPKs is mTORC1-dependent. In Rh1 cells rapamycin inhibited insulin-like growth factor-I (IGF-I)-stimulated phosphorylation of Thr(202) but not Tyr(204) and suppressed activation of p44/42 kinase activity. Down-regulation of raptor, which inhibits mTORC1 signaling, had a similar effect to rapamycin in blocking IGF-I-stimulated Tyr(204) phosphorylation. Rapamycin did not block maximal phosphorylation of Tyr(204) but retarded the rate of dephosphorylation of Tyr(204) following IGF-I stimulation. IGF-I stimulation of MEK1 phosphorylation (Ser(217/221)) was not inhibited by rapamycin. Higher concentrations of rapamycin (> or =100 ng/ml) were required to inhibit epidermal growth factor (EGF)-induced phosphorylation of p44/42 (Thr(202)). Rapamycin-induced inhibition of p44/42 (Thr(202)) phosphorylation by IGF-I was reversed by low concentrations of okadaic acid, suggesting involvement of protein phosphatase 2A (PP2A). Both IGF-I and EGF caused dissociation of PP2A catalytic subunit (PP2Ac) from p42. Whereas low concentrations of rapamycin (1 ng/ml) inhibited dissociation of PP2Ac after IGF-I stimulation, it required higher concentrations (> or =100 ng/ml) to block EGF-induced dissociation, consistent with the ability for rapamycin to attenuate growth factor-induced activation of p44/42. The effect of rapamycin on IGF-I or insulin activation of p44/42 was recapitulated by amino acid deprivation. Rapamycin effects altering the kinetics of p44/42 phosphorylation were completely abrogated in Rh1mTORrr cells that express a rapamycin-resistant mTOR, whereas the effects of amino acid deprivation were similar in Rh1 and Rh1mTORrr cells. These results indicate complex regulation of p44/42 by phosphatases downstream of mTORC1. This suggests a model in which mTORC1 modulates the phosphorylation of Thr(202) on p44/42 MAPKs through direct or indirect regulation of PP2Ac.
The role of the chloroplast in inorganic carbon acquisition by <i>Chlamydomonas reinhardtii</i> (1991)

The role of the chloroplast in algal inorganic carbon acquisition is reviewed. Unicellular green algae possess the ability to grow photoautotrophically at very low CO 2 concentrations. The presence of a CO 2 -concentrating system that elevates the CO 2 level within the cell can account for the algae's ability to reduce photorespiration and grow under these conditions. The mechanism of this inorganic carbon transport is unclear at present, although both the plasmalemma and the chloroplast have been implicated in this process. Three aspects of the role of the chloroplast in Chlamydomonas reinhardtii inorganic carbon uptake are discussed in this review. First, the present models of inorganic carbon uptake are summarized. Second, the purity and integrity of intact chloroplast preparations are discussed. Third, an evaluation of the published data on inorganic carbon uptake by isolated intact chloroplasts is presented. Key words: Chlamydomonas reinhardtii, carbonic anhydrase, chloroplast, active CO 2 uptake.
Normal Development of Mice and Unimpaired Cell Adhesion/Cell Motility/Actin-based Cytoskeleton without Compensatory Up-regulation of Ezrin or Radixin in Moesin Gene Knockout (1999)

Ezrin/radixin/moesin (ERM) proteins are general cross-linkers between the plasma membrane and actin filaments. Because their expression is regulated in a tissue-specific manner, each ERM protein has been proposed to have unique functions. On the other hand, experiments at the cellular level and in vitro have suggested their functional redundancy. To assess the possible unique functions of ERM proteins in vivo, the moesin gene located on the X chromosome was disrupted by gene targeting in embryonic stem cells. Male mice hemizygous for the mutation as well as homozygous females were completely devoid of moesin but developed normally and were fertile, with no obvious histological abnormalities in any of the tissues examined. In the tissues of the mutant mice, moesin completely disappeared without affecting the expression levels or subcellular distribution of ezrin and radixin. Also, in platelets, fibroblasts, and mast cells isolated from moesin-deficient mice, targeted disruption of the moesin gene did not affect their ERM-dependent functions, i.e. platelet aggregation, stress fiber/focal contact formation of fibroblasts, and microvillar formation of mast cells, without compensatory up-regulation of ezrin or radixin. These findings favor the notion that ERM proteins are functionally redundant at the cellular as well as the whole body level.
Flexible, dynamic injection of structured advice using byteman (2011)

Byteman is a flexible, dynamic advice injection tool for Java. It uses an Event Condition Action rule script language to structure placement and control execution of injected Java code fragments. The Byteman agent can be loaded at application startup or into a running application and rules can be loaded, unloaded and reloaded while the application continues running.
Bayesian target selection after group pattern distortion (1996)

The following problem is considered: a group of point targets is observed via an imperfect sensor and one of the measurements chosen. The measurement of each target position is corrupted by an independent error, although every object is detected. Two processes then act to move and distort the group: one is a bulk effect that acts equally on all members of the group while the other is independent for each target. The group is observed again by a (possibly different) imperfect sensor which may not detect every target. The problem is to construct the posterior distribution of the chosen target's position, given the two sets of measurements. Probability models of the sensors and of the pattern distortion processes are assumed to be available. A formal general solution has been obtained for this problem. For the special linear-Gaussian case this reduces to a closed form analytic expression. To facilitate implementation, a hypothesis pruning technique is given. A simulation example illustrating performance is provided.
A Fast Lightweight Time-Series Store for IoT Data (2016)

With the advent of the Internet-of-Things (IoT), handling large volumes of time-series data has become a growing concern. Data, generated from millions of Internet-connected sensors, will drive new IoT applications and services. A key requirement is the ability to aggregate, preprocess, index, store and analyze data with minimal latency so that time-to-insight can be reduced. In the future, we expect real-time data collection and analysis to be performed both on small devices (e.g., in hubs and appliances) as well in server-based infrastructure. The ability to localize sensitive data to the home, and thus preserve privacy, is a key driver for small-device deployment. In this paper, we present an efficient architecture for time-series data management that provides a high data ingestion rate, while still being sufficiently lightweight that it can be deployed in embedded environments or small virtual machines. Our solution strives to minimize overhead and explores what can be done without complex indexing schemes that typically, for performance reasons, must be held in main memory. We combine a simple in-memory hierarchical index, log-structured store and in-flight sort, with a high-performance data pipeline architecture that is optimized for multicore platforms. We show that our solution is able to handle streaming insertions at over 4 million records per second (on a single x86 server) while still retaining SQL query performance better than or comparable to existing RDBMS.
A Method of Blind Separation Based on Temporal Structure of Signals. (1998)

In this article, we propose an Blind Source Separation algorithm for convolutive mixture of signals. We propose a method of separating signals in the time-frequency domain. We apply the decorrelation method proposed by Molgedey and Schuster on spectrogram and reconstruct separated signals focusing on the temporal structure of the signals. We show some results of experiments with both artificially controlled data and speech data recorded in the real environment.
Modelling of drug-release from poly-disperse microencapsulated spherical particles (2002)

The topic of this paper is the experimental and theoretical study of drug-release from a system of polydisperse microencapsulated particles that, for the sake of simplicity, are assumed to be spherical. The theoretical analysis performed yields of a mathematical model to describe the physical phenomena involved in drug-release from such a system. In particular, the model is based on the hypothesis of a progressive dissolution of the internal solid drug core (due to solvent penetration through the coating) that gives a liquid solution in the region between the coating and the dissolving solid core. The existence of a concentration gradient between the inner solution and the outer release environment determines drug diffusion through the coating. The coacervation technique was adopted to microencapsulate the solid drug cores (theophylline, a bronchodilator for the treatment of chronic asthma and chronic obstructive lung disease) by an insoluble polymeric layer of ethylcellulose. The amount of drug released from these microencapsulated particles to the external receiver phase is monitored by means of a UV spectrophotometer. As the proposed model fits the experimental results well, it was concluded that it can be a good tool to design and to study this kind of drug-release system.
Design and Implementation of Smart Billing and Automated Meter Reading System for Utility Gas (2007)

Billing automation systems for public utilities (e.g. electricity, gas and water) have been widely studied and implemented in developed countries across the world. But in Pakistan, this technology is still on its way to be implemented for domestic as well as for industrial consumers. This paper explores the design, implementation and application of billing automation system for gas consumers in Pakistan. For low gas consumption (domestic consumers), a prepaid meter has been designed which needs a prepaid card to keep the gas supply continue. Similarly for high gas consumption (industrial consumers), the gas meter is wirelessly connected with the regional billing office. In this way the billing office is able to directly communicate with the meter and records its gas consumption reading. Along with the gas, this system can easily be enhanced to measure the consumption of electricity and water.
A Method to Achieve Continuous Dimming of Low Pressure Sodium and other Gas Discharge Lamps (1981)

This work describes a method for dimming of gas discharge lamps, including problematic low pressure sodium ones. Preliminary results from experimental tests on some different lamp types are given. Some possible applications of the proposed method in the area of emergency lighting are considered.
Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice (2011)

Insulin like growth factor-1 (IGF-1) stimulates increased proliferation and survival of mammary epithelial cells and also promotes mammary tumorigenesis. To study the effects of IGF-1 on the mammary gland in vivo, we used BK5.IGF-1 transgenic (Tg) mice. In these mice, IGF-1 overexpression is controlled by the bovine keratin 5 promoter and recapitulates the paracrine exposure of breast epithelium to stromal IGF-1 that is seen in women. Studies have shown that BK5.IGF-1 Tg mice are more susceptible to mammary tumorigenesis than wild-type littermates. Investigation of the mechanisms underlying increased mammary cancer risk, reported here, revealed that IGF-1 preferentially activated the PI3K/Akt pathway in glands from prepubertal Tg mice, resulting in increased cyclin D1 expression and hyperplasia. However, in glands from postpubertal Tg mice, a pathway switch occurred and activation of the Ras/Raf/MAPK pathway predominated, without increased cyclin D1 expression or proliferation. We further showed that in prepubertal Tg glands, signaling was mediated by formation of an ERα/IRS-1 complex, which activated IRS-1 and directed signaling via the PI3K/Akt pathway. Conversely, in postpubertal Tg glands, reduced ERα expression failed to stimulate formation of the ERα/IRS-1 complex, allowing signaling to proceed via the alternate Ras/Raf/MAPK pathway. These in vivo data demonstrate that changes in ERα expression at different stages of development direct IGF-1 signaling and the resulting tissue responses. As ERα levels are elevated during the prepubertal and postmenopausal stages, these may represent windows of susceptibility during which increased IGF-1 exposure maximally enhances breast cancer risk.
CD90+ Stromal Cells are Non-Professional Innate Immune Effectors of the Human Colonic Mucosa (2013)

Immune responses at the intestinal mucosa must allow for host protection whilst simultaneously avoiding inappropriate inflammation. Although much work has focused on the innate immune functionality of hematopoietic immune cells, non-hematopoietic cell populations - including epithelial and stromal cells - are now recognized as playing a key role in innate defense at this site. In this study we examined the innate immune capacity of primary human intestinal stromal cells (iSCs). CD90(+) iSCs isolated from human colonic mucosa expressed a wide array of innate immune receptors and functionally responded to stimulation with bacterial ligands. iSCs also sensed infection with live Salmonella typhimurium, rapidly expressing IL-1 family cytokines via a RIPK2/p38MAPK-dependent signaling process. In addition to responding to innate immune triggers, primary iSCs exhibited a capacity for bacterial uptake, phagocytosis, and antigen processing, although to a lesser extent than professional APCs. Thus CD90(+) iSCs represent an abundant population of "non-professional" innate immune effector cells of the human colonic mucosa and likely play an important adjunctive role in host defense and immune regulation at this site.
Prämature Menopause (1986)

In 46 patients with the diagnosis of "premature menopause" menstrual history, clinical findings and hormonal quantitations were analysed. This clinical entity was evaluated with regard to a rapid verification of the diagnosis. The age of the investigated women with secondary failure to menstruate varied between 13 to 39 years (mean value 29 years). Menstrual history varied considerably. 20 women complained about menopausal symptoms. 5 women had adnexal operations before. Vaginal hormonal cytology, gestagen test and quantitation of the circulating oestradiol concentrations were of little value for establishing the diagnosis, since many of these women revealed premenopausal oestradiol levels. Quantitation of FSH is decisive for establishing the diagnosis. In women under the age of 40 with FSH values above 1000 ng LER 907/ml or above 40 mIU/ml premature ovarian failure can be assumed; however, in individual cases the "gonadotropin resistant ovary syndrome" must be differentiated.
[The use of therapeutic apheresis in neurological diseases and comparison between plasma exchange and immunoadsorption]. (2016)

The use of plasmapheresis in neurological diseases with immune-mediated pathogenesis is widely certified. In recent years, the technological evolution of the dialysis membranes allowed to accompany the classical plasma exchange (PEX) treatment of apheresis by means of selective adsorption (IA). It has proved to be of equal therapeutic efficacy and, at the same time, devoid of most of the PEX side effects. The recent guidelines of the American Society for Apheresis (ASFA) and, later, the American Academy of Neurology, outlined directions and diagrams for the application of the method that has found wide use in many neurological diseases on the basis of auto-antibodies; in particular in Myasthenia Gravis, Guillain-Barre Syndrome, Multiple Sclerosis and Chronic Demyelinating Polyradiculoneuropathy. We add our experience in the treatment of 13 patients suffering from Myasthenia Gravis, treated over a four years period with filters containing tryptophan immunoadsorption in polyvinyl alcohol gel. The results confirm the achievement of a rapid regression of clinical symptoms, together with the rapid fall in the levels of antibody against acetylcholine-receptor. Therefore, the method of AI is to be considered of equal therapeutic efficacy of PEX, providing greater security in its use.
Nonuniformly quantized min-sum decoder architecture for low-density parity-check codes (2008)

In this paper, we propose a novel min-sum (MS) decoder architecture using nonuniform quantization schemes for low-density parity-check (LDPC) codes. The finite word-length analysis in implementing an LDPC decoder is a very important factor since it directly impacts the size of memory to store the intrinsic and extrinsic messages and the overall hardware area in the partially parallel LDPC decoder. The proposed nonuniform quantization scheme can reduce the finite word-length while achieving similar performances compared to a conventional quantization scheme. From simulation results, it is shown that the proposed 4-bits nonuniform quantization scheme achieves an acceptable decoding performance unlike a conventional 4-bits uniform quantization scheme. In addition, the hardware implementation for the proposed nonuniform quantization scheme requires smaller area.
A reliability model for systems undergoing remanufacture (1999)

grantor: University of Toronto
A Phage Display Technique Identifies a Novel Regulator of Cell Differentiation (2002)

The formation of new bone during the process of bone remodeling occurs almost exclusively at sites of prior bone resorption. In an attempt to discover what regulatory pathways are utilized by osteoblasts to effect this site-specific formation event we probed components of an active bone resorption surface with an osteoblast phage expression library. In these experiments primary cultures of rat osteoblasts were used to construct a phage display library in T7 phage. Tartrate-resistant acid phosphatase (type V) (TRAP) was used as the bait in a biopanning procedure. 40 phage clones with very high affinity for TRAP were sequenced, and of the clones with multiple consensus sequences we identified a regulatory protein that modulates osteoblast differentiation. This protein is the TGFbeta receptor-interacting protein (TRIP-1). Our data demonstrate that TRAP activation of TRIP-1 evokes a TGFbeta-like differentiation process. Specifically, TRIP-1 activation increases the activity and expression of osteoblast alkaline phosphatase, osteoprotegerin, collagen, and Runx2. Moreover, we show that TRAP interacts with TRIP intracellularly, that activation of the TGFbeta type II receptor by TRIP-1 occurs in the presence of TRAP and that the differentiation process is mediated through the Smad2/3 pathway. A final experiment demonstrates that osteoblasts, when cultured in osteoclast lacunae containing TRAP, rapidly and specifically differentiate into a mature bone-forming phenotype. We hypothesize that binding to TRAP may be one mechanism by which the full osteoblast phenotype is expressed during the process of bone remodeling.