gebhart/patrepeval huggingface dataset:
Cardiac Progenitor Cells and Bone Marrow-Derived Very Small Embryonic-Like Stem Cells for Cardiac Repair After Myocardial Infarction (2010)

Heart failure after myocardial infarction (MI) continues to be the most prevalent cause of morbidity and mortality worldwide. Although pharmaceutical agents and interventional strategies have contributed greatly to therapy, new and superior treatment modalities are urgently needed given the overall disease burden. Stem cell-based therapy is potentially a promising strategy to lead to cardiac repair after MI. An array of cell types has been explored in this respect, including skeletal myoblasts, bone marrow (BM)-derived stem cells, embryonic stem cells, and more recently, cardiac progenitor cells (CPCs). Recently studies have obtained evidence that transplantation of CPCs or BM-derived very small embryonic-like stem cells can improve cardiac function and alleviate cardiac remodeling, supporting the potential therapeutic utility of these cells for cardiac repair. This report summarizes the current data from those studies and discusses the potential implication of these cells in developing clinically-relevant stem cell-based therapeutic strategies for cardiac regeneration.
Josephson-CMOS Hybrid Memories (2013)

Abstract : Lack of high-density, fast and memory has been a long-standing problem in superconducting digital electronics. Alternative Josephson-junction-based memory cells and peripheral circuits have intrinsic problems which impede the application of that kind of memory. The CMOS-Josephson hybrid memory idea was proposed in 1992 to circumvent this problem. In the present work we have designed and demonstrated a 64-kb CMOS-Josephson hybrid memory working at 1 GHz. In order to make the hybrid idea practical, a complete and comprehensive 4 K short-channel CMOS model for digital circuits was developed for this dissertation. It has been used in the design of the memory core and peripheral circuits. A fast hybrid interface circuit that transforms single-flux-quantum millivolt 2-ps pulse signals to CMOS volt-level signals has been studied and the optimized design has been completed. Using a nonvolatile cryogenic 3-T DRAM cell, the memory core is designed in such a way that the access time is much less than for room-temperature operation, not only because of the performance upgrade due to the temperature decrease but also because of a different reading mechanism. Fabricated by commercial submicron CMOS processes (0.25 microns and 0.18 microns) and a Nb/AlOx/Nb Josephson-junction process with 2.5 kA/cm2 tunneling current density, the memory chips were bonded together by direct wire-bonding and by flip-chip bump-bonding and tested at low frequencies, high frequencies, respectively. A subnanosecond access time is obtained both from simulations and experiments. The power for an interface circuit is measured to be 0.6 mW. The memory core consumes even less power. The total power consumption depends on the operation mode of the memory and is calculated to be 10 mW for reading and 28 mW for writing. Simulations also indicate that, with more advanced semiconductor and superconductor technologies, larger and faster hybrid memories are expected to be achievable in the future.
Essentials of Diagnostic Virology (1999)

Preface Acknowledgement Methodological overview Specimen Collection and transport Central Nervous System Respiratory Gastrointestinal Skin and mucous membranes Genital Hepatitis Cardiac Ocular Urinary Tract Mononucleosis Viral Infections of Childhood Congenital Infections Viral Infections in the immunocompromised host Viral Hemorrhagic Fevers and Other Geo-graphically localized viral infections HIV and other human retroviruses Antiviral Susceptibility Testing Molecular Typing, Subtyping and analysis of viruses Discovery of New Viral Pathogens Appendices
CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers (2013)

This work suggests that CETN1 is a novel CTA with expression in cancer of the prostate and pancreas. In cell lines, the expression is probably regulated by promoter methylation, while the method of regulation in normal adult tissues remains unknown.
Estimation of dynamically varying displacement derivatives using fringe projection technique (2011)

This paper presents a pseudo Wigner-Ville-distribution-based method in fringe projection for analyzing temporal behavior of the displacement derivative for a continuously deformed object. In the proposed method, a computer generated fringe pattern is projected on an object undergoing dynamic deformation, and the reflected intensity is recorded in the form of video, i.e., a stack of images are captured sequentially by a CCD camera. Each image represents a recorded fringe pattern at a particular time instant whose phase contains information about the instantaneous out-of-plane displacement or deformation with respect to the undeformed object, and the corresponding spatial phase derivative relates to the displacement derivative. Subsequently, pseudo Wigner-Ville distribution is used for instantaneous phase derivative estimation from the stack of images. Simulation and experimental results are presented to demonstrate the method's potential.
Synthesis and Biological Evaluation of 3-Deazacytidine and 3-Deazauridine Derivatives (1986)

Abstract The synthesis of new 5-and 6- subsituted 3-deazapyrimidine ribonucleosides has been performed by reacting the silylated bases and 1-0-acetyl-2, 3, 5-tri-O-benzoyl-β-D-ribofuranose in dichloroethane in the presence of stannic chloride. None of these compounds exhibited any antiviral activity in vitro against HSV1 and RV31.
Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats. (1990)

Insulin resistance is one of pathogenic factors for non-insulin-dependent diabetes mellitus (NIDDM). Pioglitazone (5-[4-[2-(5-ethyl-2-pyridyl)-ethoxy]benzyl]-2,4-thiazolidinedione, AD-4833, also known as U-72, 107E) is a promising candidate to lower hyperglycemia by reducing insulin resistance. The genetically obese-hyperglycemic rats. Wistar fatty, were used to test the action of pioglitazone, because they develop severe insulin resistance in the peripheral tissues (muscle and adipose tissue) and liver. Pioglitazone administered orally (0.3-3 mg/kg/d for 7 days) dose dependently reduced hyperglycemia, hyperlipidemia, and hyperinsulinemia in male fatty rats. Pioglitazone improved glucose tolerance and augmented the glycemic response to exogenous insulin and clearance of plasma triglyceride. These effects on glucose and lipid metabolism seem to be due to increased insulin sensitivity and responsiveness in the peripheral tissues, because pioglitazone increased insulin-stimulated glycogen synthesis and glycolysis in the isolated soleus muscles, and insulin-stimulated glucose oxidation and lipogenesis in adipocytes. The latter effects were not accompanied by any changes in insulin binding. The actions of insulin mimickers (vanadate and vitamin K5), which act on the post-insulin binding sites, on these metabolic events were also potentiated by pioglitazone. These findings suggest that pioglitazone can improve glucose and lipid metabolism by reducing insulin resistance on the post-binding system. Therefore, pioglitazone may be efficacious for treating human NIDDM.
Head-operating mechanism improves delayed coker safety, efficiency (1989)

Improved operator safety and process operations have been accomplished by the installation of an automatic mechanism for unheading coke drums at Champlin Refining and Chemicals Petroleum Co.'s Corpus Christi, Tex., refinery. The mechanism hydraulically opens and closes a hinged coke-drum bottom head. Automatic bottom head opening improved safety by allowing the operators to be away from the full coke drum during deheading. This is particularly important when shot coke is produced, or when incomplete water draining from the drum has not been accomplished. The automatic operation of the head-opening mechanism improves coking operations by making drum switching more efficient.
Avocado (Persea americana Mill.) Phenolics, In Vitro Antioxidant and Antimicrobial Activities, and Inhibition of Lipid and Protein Oxidation in Porcine Patties (2011)

The first aim of the present work (study 1) was to analyze ethyl acetate, 70% acetone, and 70% methanol extracts of the peel, pulp, and seed from two avocado (Persea americana Mill.) varieties, namely, 'Hass' and 'Fuerte', for their phenolic composition and their in vitro antioxidant activity using the CUPRAC, DPPH, and ABTS assays. Their antimicrobial potential was also studied. Peels and seeds had higher amounts of phenolics and a more intense in vitro antioxidant potential than the pulp. Peels and seeds were rich in catechins, procyanidins, and hydroxycinnamic acids, whereas the pulp was particularly rich in hydroxybenzoic and hydroxycinnamic acids and procyanidins. The total phenolic content and antioxidant potential of avocado phenolics was affected by the extracting solvent and avocado variety. The avocado materials also displayed moderate antimicrobial effects against Gram-positive bacteria. Taking a step forward (study 2), extracts (70% acetone) from avocado peels and seeds were tested as inhibitors of oxidative reactions in meat patties. Avocado extracts protected meat lipids and proteins against oxidation with the effect on lipids being dependent on the avocado variety.
Low temperature transport properties and heat capacity of single-crystal Na<sub>8</sub>Si<sub>46</sub> (2010)

The low temperature thermal conductivity, resistivity, and Seebeck coefficient of single-crystal Na(8)Si(46) are investigated revealing the intrinsic low temperature transport properties of this material. Metallic conduction is observed, with a higher residual resistance ratio than any other known type I clathrate. Heat capacity together with thermal conductivity provide insight into the Na disorder inside the polyhedra formed by the Si framework. Single-crystal structural refinement and thermal property analyses reveal anisotropic disorder for Na inside the tetrakaidecahedra due to a reduction in the symmetry inside these polyhedra, unlike that for Na inside the dodecahedra.
Optical Studies of Injected Carriers. II. Recombination Radiation in Germanium (1953)

The radiation produced by the direct recombination of electrons and holes in germanium is studied. The observed spectral distribution is in fair agreement with theory. For injection into high resistivity, as well as into doped material, the radiation is observed to be a linear function of injection current. Possible explanations for this are discussed. Magnetic concentration of carriers produced changes in the radiation intensity. Polarization of the radiation at oblique angles of emergence is observed.
Development Situations and Countermeasures of Low Carbon Ecological Circular Agriculture: A Case Study of Nantong City (2012)

Developing the low carbon ecological circular agriculture is an effective approach to realizing low carbon development of agriculture. Through investigation on existing measures and performance of development of low carbon type ecological circular agriculture in Nantong City, we analyzed the potential and problems of Nantong City in developing low carbon type ecological circular agriculture. Finally, with reference to domestic and foreign research achievements and practical experience, we put forward countermeasures for developing low carbon type ecological circular agriculture in Nantong City from building technical system and government guidance.
La liberté d'indifférence et le déterminisme psychologique (1904)

Mercier D. La liberté d'indifférence et le déterminisme psychologique. In: Revue néo-scolastique. 11ᵉ année, n°41, 1904. pp. 5-17.
Design of Experiments (1993)

Presents a novel approach to the statistical design of experiments, offering a simple way to specify and evaluate all possible designs without restrictions to classes of named designs. The work also presents a scientific design method from the recognition stage to implementation and summarization.
Optical Absorption Edge of Ternary Semiconducting Silicide Ba<sub>1-x</sub>Sr<sub>x</sub>Si<sub>2</sub> (2006)

Polycrystalline Ba1-xSrxSi2 films with Sr composition x varying from 0 to 0.52 were grown on transparent fused silica substrates by molecular beam epitaxy. Optical absorption spectra measured at room temperature showed that the indirect absorption edge of Ba1-xSrxSi2 increases almost linearly with increasing x and reaches approximately 1.40 eV when x is 0.52. This result suggests that the band gap of Ba1-xSrxSi2 is increased by Sr addition.
Comparison of the Specific IgM and IgG Antibody Response in Humans Induced by Antigen (Tetanus Toxoid) or a Polyclonal Activator (EBV) in vitro (1983)

Culture conditions were established for the reproducible induction of specific antibody responses in vitro using peripheral blood lymphocytes from tetanus toxoid (TT) immunized donors. Maximum anti-TT antibody responses (250-350 ng/ml) were detected on day 9 of culture, with optimum quantities of antigen (0.1-1.0 micrograms/ml TT) or Epstein-Barr virus (EBV). The antigen-driven antibody response unlike the EBV-induced polyclonal response was both T-cell and monocyte-dependent. TT stimulated mainly the IgM class of anti-TT antibody whereas EBV stimulated both IgM and IgG. A combination of TT and EBV caused a partially additive IgM response but suppressed the IgG class of anti-TT antibody. Transfer of cells from 9-day EBV-stimulated cultures to fresh cultures suppressed the anti-TT antibody response, possibly due to elevated levels of OKT8+ suppressor/cytotoxic cells found in culture after EBV infection. These results provide a reliable system for studying B-cell regulation in man.
Pre-mixed partially alloyed iron powder for warm compaction: KIP clean mix HW series (2002)

Kawasaki Steel has developed Japan 's first iron powder pre-mix Clean Mix HW Series specially designed for warm compaction by incorporating KW-wax, a lubricant with high performance during warm compaction process. KW-wax realized the powder characteristics-flow rate and apparent density-stable in the wide temperature range from room temperature to 423 K. Because of this stability, HW Series does not require the rigid control of the powder temperature in the compacting process of mass production. It was also found by the study about compacting process that KW-wax promoted particles rearrangement during compaction and gave green density higher than 7.3 Mg/m 3 , having pore structures homogeneous in size and shape. The homogeneous structure of green compacts resulted in the improvement of mechanical strength of sintered and heat-treated compacts.
System for audience participation in event scoring at the 2004 Olympic Games (2004)

In this paper we describe a system for audience participation in gymnastics and diving events scoring at the 2004 Olympics in Athens, Greece. The proposed system has six primary design goals: ease-of-use, scalability, low cost, scoring accuracy, portability and resistance to tampering. The system provides a simple and portable system that can be used for any sporting event where judge scores are reviewed by an audience. The supporting database design provides for statistical analysis and portability as well by providing a generalized database structure that can be easily adapted to any event as necessary. By using off-the-shelf technologies and open-source software, the solution provides for simple implementation, inexpensive hardware requirements, and easy software development.
The Ethics of Teaching Physicians Electronic Fetal Monitoring: And Now for the Rest of the Story (2017)

Electronic fetal monitoring (EFM) does not predict or prevent cerebral palsy (CP), but this myth remains entrenched in medical training and practice. The continued use of this ineffectual diagnostic modality increases the cesarean section rate with concomitant harms to mothers and babies alike. EFM, as it is used in defensive medical practice, is a violation of patient autonomy and raises serious ethical concerns. This review addresses the need for improved graduate medical education so that physicians and medical residents are taught both sides of the EFM-CP story.
Biosurfactant as an Enhancer of Geologic Carbon Storage: Microbial Modification of Interfacial Tension and Contact Angle in Carbon dioxide/Water/Quartz Systems (2017)

Injecting and storing of carbon dioxide (CO<sub>2</sub>) in deep geologic formations is considered as one of the promising approaches for geologic carbon storage. Microbial wettability alteration of injected CO<sub>2</sub> is expected to occur naturally by microorganisms indigenous to the geologic formation or microorganisms intentionally introduced to increase CO<sub>2</sub> storage capacity in the target reservoirs. The question as to the extent of microbial CO<sub>2</sub> wettability alteration under reservoir conditions still warrants further investigation. This study investigated the effect of a lipopeptide biosurfactant-surfactin, on interfacial tension (IFT) reduction and contact angle alteration in CO<sub>2</sub>/water/quartz systems under a laboratory setup simulating <i>in situ</i> reservoir conditions. The temporal shifts in the IFT and the contact angle among CO<sub>2</sub>, brine, and quartz were monitored for different CO<sub>2</sub> phases (3 MPa, 30°C for gaseous CO<sub>2</sub>; 10 MPa, 28°C for liquid CO<sub>2</sub>; 10 MPa, 37°C for supercritical CO<sub>2</sub>) upon cultivation of <i>Bacillus subtilis</i> strain ATCC6633 with induced surfactin secretion activity. Due to the secreted surfactin, the IFT between CO<sub>2</sub> and brine decreased: from 49.5 to 30 mN/m, by ∼39% for gaseous CO<sub>2</sub>; from 28.5 to 13 mN/m, by 54% for liquid CO<sub>2</sub>; and from 32.5 to 18.5 mN/m, by ∼43% for supercritical CO<sub>2</sub>, respectively. The contact angle of a CO<sub>2</sub> droplet on a quartz disk in brine increased: from 20.5° to 23.2°, by 1.16 times for gaseous CO<sub>2</sub>; from 18.4° to 61.8°, by 3.36 times for liquid CO<sub>2</sub>; and from 35.5° to 47.7°, by 1.34 times for supercritical CO<sub>2</sub>, respectively. With the microbially altered CO<sub>2</sub> wettability, improvement in sweep efficiency of injected and displaced CO<sub>2</sub> was evaluated using 2-D pore network model simulations; again the increment in sweep efficiency was the greatest in liquid CO<sub>2</sub> phase due to the largest reduction in capillary factor. This result provides novel insights as to the role of naturally occurring biosurfactants in CO<sub>2</sub> storage and suggests that biostimulation of biosurfactant production may be a feasible technique for enhancement of CO<sub>2</sub> storage capacity.
Hydrophilic strips for preventing air bubble formation in a microfluidic chamber (2015)

In a microfluidic chamber, unwanted formation of air bubbles is a critical problem. Here, we present a hydrophilic strip array that prevents air bubble formation in a microfluidic chamber. The array is located on the top surface of the chamber, which has a large variation in width, and consists of a repeated arrangement of super- and moderately hydrophilic strips. This repeated arrangement allows a flat meniscus (i.e. liquid front) to form when various solutions consisting of a single stream or two parallel streams with different hydrophilicities move through the chamber. The flat meniscus produced by the array completely prevents the formation of bubbles. Without the array in the chamber, the meniscus shape is highly convex, and bubbles frequently form in the chamber. This hydrophilic strip array will facilitate the use of a microfluidic chamber with a large variation in width for various microfluidic applications.
A Subambient Open Roof Surface under the Mid‐Summer Sun (2015)

<b>A novel material open to warm air</b> stays below ambient temperature under maximum solar intensities of mid-summer. It is found to be 11 °C cooler than a commercial white cool roof nearby. A combination of specially chosen polymers and a silver thin film yields values near 100% for both solar reflectance, and thermal emittance at infrared wavelengths from 7.9 to 13 μm.
Chymostatin can combine with pepstatin to eliminate extracellular protease activity in cultures of Aspergillus niger NRRL-3 (2006)

Aspergillus strains are being considered as potential hosts for recombinant heterologous protein production because of their excellent extracellular enzyme production characteristics. However, Aspergillus proteases are problematic in that they modify and degrade the heterologous proteins in the extracellular medium. In previous studies we observed that media adjustments and maintenance of a filamentous morphology greatly reduced protease activity and that a low concentration of the aspartic protease inhibitor pepstatin inhibited the latter protease activity to the extent of approximately 90%. In this paper we report that when the serine protease inhibitor chymostatin is used in combination with pepstatin 99-100% of total protease activity in Aspergillus cultures is inhibited. In protease assays a concentration of 30 microM chymostatin combined with 0.075 microM pepstatin was required for maximum inhibition. Inhibitor concentrations of chymostatin and pepstatin of 120 and 0.3 microM, respectively, when added to Aspergillus cultures, has no significant effect on biomass production, glucose utilization or culture pH pattern. The potential of using these protease inhibitors in cultures of recombinant Aspergillus strains producing heterologous proteins will now be investigated to determine if the previously observed recombinant protein denaturing effects of Aspergillus proteases can be negated.
High Speed Acoustic Telemetry Network Enables Real-Time Along String Measurements, Greatly Reducing Drilling Risk (2011)

Abstract A unique multi-node acoustic telemetry network capable of transmitting data at over 30 bits per second has been developed and successfully deployed in drilling applications. This paper details the lessons learned and value derived from early use of the acoustic telemetry network while drilling medium radius build sections of multiple horizontal wells. Particular focus is given to discussion of overall network reliability, ease of well-site implementation and delivery of pressure data from multiple along-string measurement locations with or without fluid circulation. Low latency, high-speed, real-time transmission of pressure data (from near the bit and other key locations along the borehole) allows highly accurate, potentially automated management of annular pressure to avoid unintentional formation fracture or fluid influx during drilling and non-drilling activities. This data can also be utilized to understand hole cleaning effectiveness in different sections of a well, allowing focused corrective action to be taken at the first sign of cuttings build-up, potentially avoiding costly stuck pipe incidents. In addition, continuous data transmission without the need for fluid circulation enables significant risk reduction when addressing well control incidents. Highly reliable tools placed up to 2,500 meters apart establish the acoustic telemetry network within existing drill strings and in conjunction with all bottom hole assembly components. It is virtually transparent to all rig operations and, as a result, significantly decreases the implementation time and cost when compared to along string measurement solutions delivered by wired drill string technology. This is the first publication of information from such field deployments and the first display of multi-node pressure data delivered via acoustic telemetry while drilling.