gebhart/patrepeval huggingface dataset:
Morphology and hydrolysis of PCL/PLLA blends compatibilized with P(LLA‐<i>co</i>‐ϵCL) or P(LLA‐<i>b</i>‐ϵCL) (2002)

Abstract The effect of the compatibilizers, P(LLA‐ co ‐ϵCL) and P(LLA‐ b ‐ϵCL), on the morphology and hydrolysis of the blend of poly(ϵ‐caprolactone) (PCL) and poly( L ‐lactide) (PLLA) was investigated. An addition of P(LLA‐ co ‐ϵCL) or P(LLA‐ b ‐ϵCL) into the blend could enhance the compatibility between the dispersed PCL domains and the PLLA matrix. The size of the PCL domains in the PLLA/PCL (70/30) blend containing P(LLA‐ co ‐ϵCL) reduced more significantly with an increase in the content of the compatibilizer than that in the blend containing P(LLA‐ b ‐ϵCL). The molecular weight of the PLLA/PCL blend films compatibilized with P(LLA‐ co ‐ϵCL) or P(LLA‐ b ‐ϵCL) decreased during the hydrolysis and the decrease of the molecular weight of the blend films compatibilized with P(LLA‐ co ‐ϵCL) was much more significant than that of the blend films compatibilized with P(LLA‐ b ‐ϵCL). © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1892–1898, 2002
Potassium channel blockers as immunosuppressants (2005)

AbstractRecent advances in the biology of potassium channels have raised their profile as therapeutic targets for immunosuppression. Selective blockade of the intermediate-conductance calcium-activated potassium channel KCa3.1, and in particular, the voltage-gated potassium channel, Kv1.3 holds great promise in the modulation of different subsets of inflammatory T cells and B cells involved in the pathogenesis of autoimmune and inflammatory diseases. Relatively few selective blockers of these channels have been discovered to date, but this situation is likely to change as these channels become increasingly prominent as tractable and selective therapeutic targets, and especially if they are clinically validated as immunosuppressive targets.Keywords:: experimental autoimmune encephalomyelitis (EAE)IKIKCa1immunosuppressantimmunosuppressionKCa3.1KCNA3KNNC4Kv1.3multiple sclerosis (MS)potassium channel blocker
The Renal Pelvis: Machinery That Concentrates Urine in the Papilla (2003)

Two decades ago, Bodil Schmidt-Nielsen and Bruce Graves documented the rhythmic contractions of the renal pelvis in a remarkable video, visually demonstrating how peristaltic waves empty the papilla and how the subsequent elastic recoil draws water from the collecting duct and into the tethered-open ascending vasa recta. Thus a periodic hydrostatic gradient generates an axial osmotic gradient. This review recapitulates the video and offers a link to figures and scenes digitized from the original tape.
File organizations and access methods for CLV disks (1989)

A large and important class of optical disc technology are CLV format discs such as CD ROM and WORM. In this paper, we examine the issues related to the implementation and performance of several different file organizations on CLV format optical discs such as CD ROM and WORM. The organizations examined are based on hashing and trees.
Hepatitis C Infection, Time in Renal-Replacement Therapy, and Outcome after Kidney Transplantation (2004)

HCV was, in our series, more important than time in RRT for patient death and graft loss posttransplant. Successful pretransplant antiviral therapy could be more beneficial for HCV-infected patients rather than early transplantation for long-term outcome, but this needs to be studied prospectively.
Autoantibodies against alanyl-tRNA synthetase and tRNAAla coexist and are associated with myositis. (1986)

The sera of six patients with autoimmune disease, predominantly myositis with pulmonary fibrosis, contain antibodies of the PL-12 specificity. These autoantibodies react with both protein and RNA components of human cells. The protein has a subunit molecular mass of 110 kD, and the RNA comprises a group of bands in the tRNA size class. Aminoacylation experiments identify the antigens as alanyl-tRNA synthetase and its corresponding tRNAs, tRNAAla. Anti-tRNA antibody can be absorbed out without depleting antisynthetase activity, showing that the antigens are recognized independently by separable antibodies that coexist in these sera. The concurrence of separate antibodies to the two components suggests that the autoimmune response may be mounted against the charging enzyme-tRNA complex. However, the antisynthetase antibody fails to coprecipitate tRNA with the enzyme, suggesting that the antibody reacts with its target only when it is not complexed with tRNA.
Studies on the absorption of practically water-insoluble drugs following injection. II. Intramuscular absorption from aqueous suspensions in rats. (1981)

The absorption characteristics and kinetics of practically water-insoluble drugs following intramuscular injection of their aqueous suspensions were investigated by the local clearance method in the m. gastrocnemius of the rat. The plot of the cube root of the residual fraction of the drug in the injection site versus time gave a good straight line. Between the absorption rate constant (j) and the initial drug concentration (C0) or injection volume (V0), the relationship j∝C0g V0h was observed experimentally (g=-0.55 and h=-0.32). Comparison of j values among various compounds having different solubilities in saline (Cs') but similar colloidal properties (particle size distribution and sedimentation volume) showed that a plot of log j against log Cs'gave a linear relationship with a slope close to 0.5. The absorption rate constant (j) increased with decreasing particle size on condition that the other colloidal properties changed little. This increase was remarkable in the region of mean particle diameter (Dss) less than 2-3 μm, while it was gradual or slight in the region above this. The results could be explained by a kinetic model in which the dissolution (diffusion) process from the particle agglomerate formed by injection was assumed to be a rate-limiting step for the drug absorption. The effect of the type or concentration of the macromolecular dispersing agent was also examined in detail.
Noninvasive respiratory monitoring system based on the piezoceramic transducer’s pyroelectric effect (2008)

This paper presents a simple alternative method and system for noninvasive respiratory airflow monitoring. The proposed system uses a piezoceramic transducer to measure respiratory airflow. When a piezoceramic transducer is impacted by respiratory airflow, there is a piezoelectric and a pyroelectric response to pressure and thermal airflow fluctuations. In this study, the selected transducer's response output is dominated by the pyroelectricity factor. Therefore, the piezoelectric effect is not significant and can be ignored in this study. Using the transducer's pyroelectricity to measure thermal flow variations, a subject's respiratory rate and respiratory air volumetric flow rate can be monitored. The proposed system was evaluated for accuracy and response time using quiet and postphysical exertion breathing modes. Using the pneumotach system as a benchmark, the proposed system's respiratory rate measurement accuracy for the two breathing modes is approximately 98.78%. In addition, the proposed system's output voltage is highly correlated with the respiratory volumetric flow rate measured by the selected pneumotach (r2=0.9783). The average correlation coefficient between the pneumotach system's output waveform and the proposed system is approximately 0.9389. Moreover, the proposed system and the selected pneumotach have almost the same rapid response time to respiratory airflow. When compared to a temperature measurement thermistor system, the thermistor on average is approximately 25.3 ms slower than the proposed system. Furthermore, compared to the selected screen-type pneumotach system, the proposed system simplifies the respiration monitoring requirements. Instead of sensing the pressure drop across a mesh screen, like the screen-type pneumotach, it measures respiration at one point within the respiratory airflow. The proposed system benefits from simplified processing circuits and a mesh-free design. The advantages of this new respiratory airflow measurement method are fast response time, high accuracy, low cost, and ease of implementation.
Inside Cover: Ketimido Metallophthalocyanines: An Approach to Phthalocyanine‐Supported Mononuclear High‐Valent Ruthenium Complexes (Chem. Asian J. 1/2014) (2013)

Phthalocyanines High-valent ruthenium phthalocyanine complexes are difficult to isolate owing to facile oxidation of the coordinated phthalocyanine ligands. In their Full Paper on page 338 ff., featured on the Inside Cover, Chi-Ming Che, Jie-Sheng Huang, Sharon Lai-Fung Chan et al. describe a “metal–ketimine+ArI(OR)2” approach to prepare metal–ketimido (MNCR2) complexes by oxidative deprotonation, thereby leading to the isolation of ketimido metallophthalocyanine complexes [RuIV(Pc)(NCR2)2]. These complexes exhibit interesting UV/Vis and 1H NMR spectra and undergo reductive protonation with phenols; their electronic structures and UV/Vis spectra have been studied by density functional theory calculations.
Very Efficient Visible-Light-Induced Uphill Electron Transfer at a Self-Assembled Monolayer with a Porphyrin−Ferrocene−Thiol Linked Molecule (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTVery Efficient Visible-Light-Induced Uphill Electron Transfer at a Self-Assembled Monolayer with a Porphyrin−Ferrocene−Thiol Linked MoleculeKohei Uosaki, Toshihiro Kondo, Xue-Qun Zhang, and Masatoshi YanagidaView Author Information Physical Chemistry Laboratory, Division of Chemistry Graduate School of Science, Hokkaido University Sapporo 060, Japan Cite this: J. Am. Chem. Soc. 1997, 119, 35, 8367–8368Publication Date (Web):September 3, 1997Publication History Received25 March 1997Published online3 September 1997Published inissue 1 September 1997https://pubs.acs.org/doi/10.1021/ja970945phttps://doi.org/10.1021/ja970945prapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views2026Altmetric-Citations250LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Electrodes,Gold,Molecules,Photonics,Pyrroles Get e-Alerts
Genome-Wide Microarray Analysis of Long Non-Coding RNAs in Eutopic Secretory Endometrium with Endometriosis (2015)

These dysregulated lncRNAs might provide information for new biomarkers or novel therapeutic targets of endometriosis. AC002454.1 might induce cell cycle disorder by regulating CDK6 to participate in the pathogenesis of endometriosis.
A general and practicable synthesis of polycyclic heteroaromatic compounds. Part 2. Reaction of quinone-methides of pyridones, pyrimidines, coumarin, and benzene with aromatic amines in a novel synthesis of polycyclic heteroaromatic compounds (1980)

The synthesis of polycyclic heteroaromatic compounds using the reaction of a quinone-methide, generated in situ, with an aromatic amine has been successfully extended using quinone-methides of coumarin and of pyridones. Preliminary studies with the benzenoid quinone-methide (33) have so far proved to give only low yields of the expected acridines. Generation of ‘quinone-methides’ in which the carbonyl is part of an amide group did not lead to polycyclic heteroaromatic compounds.
Engineering the fatty acid metabolic pathway in Saccharomyces cerevisiae for advanced biofuel production (2015)

Fatty acid-derived fuels and chemicals have attracted a great deal of attention in recent decades, due to their following properties of high compatibility to gasoline-based fuels and existing infrastructure for their direct utilization, storage and distribution. The yeast <i>Saccharomyces cerevisiae</i> is the ideal biofuel producing candidate, based on the wealth of available genetic information and versatile tools designed to manipulate its metabolic pathways. Engineering the fatty acid metabolic pathways in <i>S. cerevisiae</i> is an effective strategy to increase its fatty acid biosynthesis and provide more pathway precursors for production of targeted products. This review summarizes the recent progress in metabolic engineering of yeast cells for fatty acids and fatty acid derivatives production, including the regulation of acetyl-CoA biosynthesis, NADPH production, fatty acid elongation, and the accumulation of activated precursors of fatty acids for converting enzymes. By introducing specific enzymes in the engineered strains, a powerful platform with a scalable, controllable and economic route for advanced biofuel production has been established.
Heart rate and haemodynamics after autonomic blockade in infants and children. (1970)

In order to assess the role of the autonomic system in the age differences in heart rate, propranolol 0.2 mg./kg. and atropine 30 micrograms/kg. were given to 103 infants and children during the course of heart catheterization. Mean control minute heart rate varied from 118 at age 1 year to 81 at age 16 years. Heart rate after drugs was termed intrinsic heart rate after Jose, and the mean varied from 139 at age 1 to 102 at age 16 years. After propranolol alone, mean heart rate was 120 at age 1, 71 at age 16, and after atropine corresponding rates were 162 and 128. The scatter in predicting heart rate from age was not lessened by autonomic blockade, suggesting that inter-individual variations in heart rate are not entirely dependent on different levels of autonomic function. The inverse relation between heart rate and age persisted after autonomic blockade, indicating that different levels of autonomic function are not responsible for the age differences in heart rate. The most important determinant of the heart rate after blockade was the initial control heart rate. Increases in cardiac index followed autonomic blockade in patients over 4 years of age and in patients without intracardiac shunts, while stroke index decreased, and femoral artery pressure increased 2/7 mm. Hg.
The Acquired Immunodeficiency Syndrome (1983)

Recently, a new epidemic illness, the acquired immunodeficiency syndrome, has dramatically emerged in the United States, Europe, and Haiti. The syndrome represents an unprecedented epidemic form of immunodeficiency involving prominent defects of the T-lymphocyte arm of the immune system. Pneumocystis carinii pneumonia, other opportunistic infections, and the previously rare cancer, Kaposi's sarcoma, are the most conspicuous illnesses that have this profound state of immune compromise as their underlying basis. Two years after the onset of clinical illness the case-fatality rate may exceed 90%. A steadily growing body of epidemiologic evidence indicates an infectious (probably viral) cause of the immunodeficiency although the responsible agent(s) remains obscure. Critical issues surrounding the diagnosis, screening of blood products, treatment of complicating infections and cancers, and prognosis for immunologic recovery in affected persons are unresolved. The identification of the cause of acquired immunodeficiency syndrome and the institution of effective preventive measures require the urgent attention of the medical and scientific community worldwide.
Νεφρική ανεπάρκεια και οστεομαλακία σε ασθενή με λοίμωξη από ΗIV (2010)

Πeριγράφeται η πeρίπτωση ασθeνούς, γυναίκας 48 eτών, μe λοίμωξη από ιό HIV η οποία από τeτραeτίας eλάμβανe θeραπeία μe lopinavir efavirenz και tenofovir. Η νeφρική της λeιτουργία ήταν φυσιολογική και το ίζημα των ούρων χωρίς eυρήματα. Μeτά από τρία έτη eμφάνισe οστικά άλγη προοδeυτικά eπιδeινούμeνα και μυική αδυναμία που σe ένα eξάμηνο οδήγησe σe αδυναμία βάδισης. Από την κλινική eξέταση κατά την eισαγωγή της διαπιστώθηκe κeντρομeλική αδυναμία, λιποδυστροφία, καταργημένα τeνόντια αντανακλαστικά, άλγος και πeριορισμός κινήσeων των κάτω άκρων. O eργαστηριακός έλeγχος έδeιξe νeφρική ανeπάρκeια μe κρeατινίνη 1,8 mg/dl, ουρία 53 mg/dl, λeυκωματουρία (3,12 g/24ωρο) και σύνδρομο Fanconi μe γλυκοζουρία (300 mg/dl), γeνικeυμένη αμινοξυουρία, φωσφατουρία (TmP/GFR: 1,4 mg/dl) και μeταβολική οξέωση μe διττανθρακικά 13 mmol/L. Η αλκαλική φωσφατάση και η παραθορμόνη ήταν αυξημένeς (ALP: 811 IU/L, iPTH: 126 pg/ml) και τα eπίπeδα της 25(OH) βιτ.D και 1,25 (OH)2 βιτ.D eλαττωμένα (13,4 ng/ml και 1,5 pg/ml αντίστοιχα). Η βιοψία νeφρού έδeιξe διάμeση ίνωση και eστιακή σπeιραματοσκλήρυνση. Διeνeργήθηκe βιοψία οστού που ανέδeιξe φυσιολογική οστική μάζα μe αύξηση του οστeοeιδούς τόσο στο φλοιό, όσο και στις οστέϊνeς δοκίδeς. Τα παραπάνω eυρήματα ήταν συμβατά μe οστeομαλακία. Διακόπηκe η αγωγή μe το Τenofovir και η ασθeνής τέθηκe σe αγωγή μe χοληκαλσιφeρόλη 1200 mg και αλφακαλσιδόλη 3 μg/ημέρα. Έξι μήνeς μeτά υποχώρησαν η μυική αδυναμία και οι οστικοί πόνοι και η νeφρική λeιτουργία βeλτιώθηκe τόσο ως προς τη σπeιραματική λeιτουργία όσο και ως προς το σύνδρομο Fanconi. Το σύνδρομο Fanconi σe συνδυασμό μe την ανeπάρκeια 25(OΗ) βιτ.D eνοχοποιήθηκαν στην συγκeκριμένη ασθeνή για τη μeγάλη έλλeιψη της 1,25(OH)2 βιτ.D και τη βαριά οστeομαλακία
SAW and CMOS RFID transponder-based wireless systems and their applications (2012)

Today, there exists a huge market pull towards radio frequency identification (RFID) and/or wireless sensing for high-volume applications as well as for professional applications based on the use of passive, i.e. batteryless, low-cost transponders (tags, labels). In order to arrive at smaller transponder dimensions, higher transceiver-to-transponder interdistances, and more flexible, i.e. application-dependent antenna designs, higher than LF/HF-carrier frequencies are required. Two of the most interesting key technologies for these mass-market applications are, respectivly, the SAW technology and the CMOS technology both of which being able to provide single-chip passive transponders. CMOS has taken the lead in the high-volume markets. Here, the development trends for RFID transponders go towards bi-or even triple-frequent operation at the 13 MHz, 900 MHz, and 2.4 GHz bands, and towards the integration of sensor and energy harvesting functionalities. SAW RFID techniques are going to find their markets in lower volume, professional application markets. SAW RFID transponders are radiation hard, and they can operate in harsh environments and at temperatures higher than 400 °C. The present work explains the system architectures of passive RFID sensing systems and reviews the state-of-the-art of SAW transponders as well as of CMOS transponders for such applications. Furthermore the advantages and shortcomings of both SAW and passive CMOS transponders, as well as future trends will be discussed.
Factors Associated With Dietary Supplement Use Among Prescription Medication Users (2006)

One in 4 prescription medication users took an NVDS in the prior 12 months, yet the majority did not share this with a conventional medical professional.
National Water Quality Goals and Irrigated Agriculture (1977)

The 1972 Federal Water Pollution Control Act Amendments (P.L. 92-500) have an important but often overlooked impact on the irrigated agricultural community of the western United States. The specific goals of P.L. 92-500 are unrealistic because of the lack of both knowledge and funds to develop effective control technologies in regard to irrigation return flows. Surface and subsurface return flows should be differentiated for purposes of study, treatment, and management. Treatment and salt disposal require expensive and complicated technologies. Some states have been granted the authority to oversee the issuance of National Pollution Discharge Elimination System permits; irrigation entities in both California and Washington have formed large return flow groups to facilitate the collection of water quality data and to assist the farmer in developing the best practical control technology. The agricultural user also needs information on the relationship between crop yield and irrigation water quality; the ASCE Task Committee was formed to study the salinity hazards faced by the irrigator.
2007 Update on Allogeneic Islet Transplantation from the Collaborative Islet Transplant Registry (CITR) (2009)

As of October 1, 2007, 25 North American medical institutions and one European islet transplant center reported detailed information to the Registry on 315 allograft recipients, of which 285 were islet alone (IA) and 30 were islet after kidney (IAK). Of the 114 IA recipients expected at 4 years after their last infusion, 12% were insulin independent, 16% were insulin dependent with detectable C-peptide, 40% had no detectable C-peptide, and 32% had missing C-peptide data or were lost to follow-up. Of the IA recipients, 72% achieved insulin independence at least once over 3 years and multiple infusions. Factors associated with achievement of insulin independence included islet size >1.0 expressed as IEQs per islet number [hazard ratio (HR) = 1.5, p = 0.06], additional infusions given (HR = 1.5, p = 0.01), lower pretransplant HbA(1c) (HR = 1.2 each %-age unit, p = 0.02), donor given insulin (HR = 2, p = 0.003), daclizumab given at any infusion (HR = 1.9, p = 0.06), and shorter cold storage time (HR = 1.04, p = 0.03), mutually adjusted in a multivariate model. Severe hypoglycemia prevalence was reduced from 78-83% preinfusion to less than 5% throughout the first year post-last infusion, and to 18% adjusted for missing data at 3 years post-last infusion. In Year 1 post-first infusion for IA recipients, 53% experienced a Grade 3-5 or serious adverse event (AE) and 35% experienced a severe AE related to either an infusion procedure or immunosuppression. In Year 1 post-first infusion, 33% of IA subjects and 35% of IAK subjects had an AE related to the infusion procedure, while 35% of IA subjects and only 27% of IAK subjects had an AE related to the immunosuppression therapy. Five deaths were reported, of which two were classified as probably related to the infusion procedure or immunosuppression, and 10 cases of neoplasm, of which two were classified as probably related to the procedure or immunosuppression. Islet transplantation continues to show short-term benefits of insulin independence, normal or near normal HbA(1C) levels, and sustained marked decrease in hypoglycemic episodes.