gebhart/patrepeval huggingface dataset:
Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin (1998)

Glial cells produce myelin and contribute to axonal morphology in the nervous system. Two myelin membrane proteolipids, PLP and DM20, were shown to be essential for the integrity of myelinated axons. In the absence of PLP-DM20, mice assembled compact myelin sheaths but subsequently developed widespread axonal swellings and degeneration, associated predominantly with small-caliber nerve fibers. Similar swellings were absent in dysmyelinated shiverer mice, which lack myelin basic protein (MBP), but recurred in MBP*PLP double mutants. Thus, fiber degeneration, which was probably secondary to impaired axonal transport, could indicate that myelinated axons require local oligodendroglial support.
A review of the findings on computed cranial tomography following intravenous contrast media. (1977)

The magnetic reversal of epitaxial Fe/Cr/Fe trilayer samples grown on GaAs is studied. In wedged samples both long and short period coupling oscillations associated with Ruderman–Kittel–Kasuya–Yosida (RKKY) coupling in Cr are seen in the easy axis saturation fields. By using vector vibrating sample magnetometry and both longitudinal and transverse magneto-optical Kerr effect magnetometry we are able to determine the exact reversal path of both the magnetic layers. Changes in the reversal behavior are seen with sub-monolayer changes of the thickness of the Cr interlayer. The two main reversal paths are described in terms of whether the reversal is dominated by bilinear RKKY coupling, which leads to an antiparallel state at remanence or by biquadratic coupling which leads to a 90 degree alignment of layers at remanence. The changing reversal behaviour is discussed with respect to the possibility of using such systems for multilayer memory applications and, in particular, the limits on the required accuracy of the sample growth.
Stereoblock Copolymers and Tacticity Control in Controlled/Living Radical Polymerization (2003)

Three controlled/living radical polymerization processes, atom transfer radical polymerization (ATRP), reversible addition-fragmentation transfer (RAFT) polymerization, and nitroxide-mediated polymerization (NMP), were investigated for the polymerization of N,N-dimethylacrylamide in the presence of Lewis acids known to enhance isotacticity, such as yttrium trifluoromethanesulfonate (Y(OTf)(3)) and ytterbium trifluoromethanesulfonate (Yb(OTf)(3)). Poly(N,N-dimethylacrylamide) with controlled molecular weight, low polydispersity (M(w)/M(n) < 1.2), and a high proportion of meso dyads ( approximately 85%) was prepared by ATRP (with initiating system methyl 2-chloropropionate/CuCl/Me(6)TREN) and RAFT (with cumyl dithiobenzoate transfer agent) in the presence of Y(OTf)(3). The combination of NMP (using N-tert-butyl-1-diethylphosphono-2,2-dimethylpropyl nitroxide, SG1) and a Lewis acid complexation technique led to less precise control over chain architecture and microstructure ( approximately 65% meso dyads), as compared to RAFT/Y(OTf)(3) or ATRP/Y(OTf)(3). The latter two systems were used for the first one-pot synthesis of stereoblock copolymers by radical polymerization. Well-defined stereoblock copolymers, atactic-b-isotactic poly(N,N-dimethylacrylamides), were obtained by adding Y(OTf)(3) at a given time to either RAFT or ATRP polymerizations, initially started without the presence of the Lewis acid.
O avesso do avesso do avesso. Linhas retas e oblíquas da paródia na telenovela brasileira (2017)

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PCR ribotyping of Clostridium difficile isolates originating from human and animal sources (2005)

Molecular typing of Clostridium difficile isolates from animals and humans may be useful for evaluation of the possibility for interspecies transmission. The objective of this study was to evaluate C. difficile isolates from domestic animals and humans using PCR ribotyping. Isolates were also tested using PCR for the presence of genes encoding toxins A and B. One hundred and thirty-three isolates of C. difficile from dogs (n = 92), horses (n = 21) and humans (n = 20), plus one each from a cat and a calf, were evaluated. Overall, 23 ribotypes were identified. Of these, nine were identified from dogs, 12 from horses, seven from humans and one each from the cat and calf. In dogs, humans and horses, one or two different ribotypes predominated. Overall, 25 % of isolates from humans were indistinguishable from isolates from one or more animal species. Genes encoding C. difficile toxins A and B were detected in all human, equine and bovine isolates, and in 69 % of canine isolates. While different ribotypes appear to predominate in different mammalian species, several indistinguishable strains may be found in multiple species. This suggests that there is a potential for interspecies transmission of C. difficile and epidemiological studies are warranted.
Elucidation of the function of lipoprotein-sorting signals that determine membrane localization (2002)

Escherichia coli lipoproteins are anchored to the inner or outer membrane depending on the residue at position 2. Aspartate at this position makes lipoproteins specific to the inner membrane, whereas other residues cause the release of lipoproteins from the inner membrane in a manner dependent on both ATP binding cassette (ABC) transporter LolCDE and molecular chaperone LolA, followed by LolB-dependent localization in the outer membrane. The function of lipoprotein-sorting signals was examined in proteoliposomes reconstituted from LolCDE and lipoproteins. The release of outer membrane-specific lipoproteins was inhibited on reconstitution with other outer membrane-specific, but not inner membrane-specific, lipoproteins. Outer membrane-specific lipoproteins stimulated ATP hydrolysis by LolCDE whereas inner membrane-specific ones did not. LolA was not required for the stimulation of ATP hydrolysis. These results revealed a previously undocumented function of aspartate at position 2, i.e., lipoproteins having this signal avoid being recognized by LolCDE, thereby remaining in the inner membrane.
Artemisinin (qinghaosu): a new type of antimalarial drug (1992)

A. R. Butler and Y. Wu, Chem. Soc. Rev., 1992, 21, 85 DOI: 10.1039/CS9922100085
Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts (2010)

The emergence and global spread of carbapenemase-producing Enterobacteriaceae is of great concern to health services worldwide. These bacteria are often resistant to all beta-lactam antibiotics and frequently co-resistant to most other antibiotics, leaving very few treatment options. The epidemiology is compounded by the diversity of carbapenem-hydrolysing enzymes and the ability of their genes to spread between different bacterial species. Difficulties are also encountered by laboratories when trying to detect carbapenemase production during routine diagnostic procedures due to an often heterogeneous expression of resistance. Some of the resistance genes are associated with successful clonal lineages which have a selective advantage in those hospitals where antimicrobial use is high and opportunities for transmission exist; others are more often associated with transmissible plasmids. A genetically distinct strain of Klebsiella pneumoniae sequence type (ST) 258 harbouring the K. pneumoniae carbapenemases (KPC) has been causing epidemics of national and international proportions. It follows the pathways of patient referrals, causing hospital outbreaks along the way. Simultaneously, diverse strains harbouring New Delhi metallo-beta-lactamase (NDM-1) are repeatedly being imported into Europe, commonly via patients with prior medical exposure in the Indian subcontinent. Since the nature and scale of carbapenem-non-susceptible Entrobacteriaceae as a threat to hospital patients in Europe remains unclear, a consultation of experts from 31 countries set out to identify the gaps in diagnostic and response capacity, to index the magnitude of carbapenem-non-susceptibility across Europe using a novel five-level staging system, and to provide elements of a strategy to combat this public health issue in a concerted manner
Banned in Detroit (1973)

Other| March 01 1973 Banned in Detroit Jamie Miller Jamie Miller Search for other works by this author on: This Site PubMed Google Scholar Afterimage (1973) 1 (6): 12. https://doi.org/10.1525/aft.1973.1.6.12 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Jamie Miller; Banned in Detroit. Afterimage 1 March 1973; 1 (6): 12. doi: https://doi.org/10.1525/aft.1973.1.6.12 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAfterimage Search This content is only available via PDF. © 1973 by The Regents of the University of California1973 Article PDF first page preview Close Modal You do not currently have access to this content.
High-speed microprogrammable asynchronous controller modules (1994)

A unique family of high-speed, microprogrammable asynchronous controller (MAC) modules is described in this correspondence. Each MAC module consists of two fundamental mode machines that communicate by means of a handshake interface that permits it to be driven by any programmable logic device including ROM's. Any state machine controller designed with a MAC module will operate free of critical races, essential hazards and output race glitches, and will have static hazard-free state variables. A multiplicity of programmable logic devices can be used to drive one or more MAC modules to achieve complex, but reliable, asynchronous, time-shared and/or parallel processing of data. Individual MAC modules having state variables numbering l,m,n,...can be cascaded to produce an available system state capacity of 2/sup lspl times/2/sup mspl times/2/sup nspl times/...states with up to (l+m+n+...)-way transition capability, all without compromising speed or reliability.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
In Vitro Cardiovascular System Emulator (Bioreactor) for the Simulation of Normal and Diseased Conditions With and Without Mechanical Circulatory Support (2013)

This article presents a new device designed to simulate in vitro flow rates, pressures, and other parameters representing normal and diseased conditions of the human cardiovascular system. Such devices are sometimes called bioreactors or "mock" simulator of cardiovascular loops (SCVLs) in literature. Most SCVLs simulate the systemic circulation only and have inherent limitations in studying the interaction of left and right sides of circulation. Those SCVLs that include both left and right sides of the circulation utilize header reservoirs simulating cycles with constant atrial pressures. The SCVL described in this article includes models for all four chambers of the heart, and the systemic and pulmonary circulation loops. Each heart chamber is accurately activated by a separate linear motor to simulate the suction and ejection stages, thus capturing important features in the perfusion waveforms. Four mechanical heart valves corresponding to mitral, pulmonary, tricuspid, and aortic are used to control the desired unidirectional flow. This SCVL can emulate different physiological and pathological conditions of the human cardiovascular system by controlling the different parameters of blood circulation through the vascular tree (mainly the resistance, compliance, and elastance of the heart chambers). In this study, four cases were simulated: healthy, congestive heart failure, left ventricular diastolic dysfunction conditions, and left ventricular dysfunction with the addition of a mechanical circulatory support (MCS) device. Hemodynamic parameters including resistance, pressure, and flow have been investigated at aortic sinus, carotid artery, and pulmonary artery, respectively. The addition of an MCS device resulted in a significant reduction in mean blood pressure and re-establishment of cardiac output. In all cases, the experimental results are compared with human physiology and numerical simulations. The results show the capability of the SCVL to replicate various physiological and pathological conditions with and without MCS.
Isolation of Human Prostatic Epithelial Plasma Membranes for Proteomics Using Mirror Image Tissue Banking of Radical Prostatectomy Specimens (2006)

We have successfully isolated purified epithelial plasma membranes from benign and malignant human prostates and provided validation data for the accuracy of our protocol in a prostate-specific antigen-screened cohort. Our method also enabled the retrieval of banked tissues for clinical purposes with the retention of good histologic and immunohistochemical quality.
MySQL and mSQL (1999)

From the Book:
This book teaches you how to use MySQL and mSQL, two popular, easy-to-use databases forLinux and UNIX systems that support key subsets of SQL. Anyone who knows basic C, Java, Perl,or Python can write a program to interact with a database, either as a stand-alone application orthrough a Web page. This book takes you through the whole process, from installation andconfiguration to programming interfaces and basic administration. Includes ample tutorial material.
Bretherick's handbook of reactive chemical hazards (2007)

Bretherick's handbook of reactive chemical hazards , Bretherick's handbook of reactive chemical hazards , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
Flag fault-tolerant error correction, measurement, and quantum computation for cyclic Calderbank-Shor-Steane codes (2020)

Flag qubits have recently been proposed in syndrome extraction circuits to detect high-weight errors arising from fewer faults. The use of flag qubits allows the construction of fault-tolerant protocols with the fewest number of ancillas known to date. In this work, we prove some critical properties of Calderbank-Shor-Steane (CSS) codes constructed from classical cyclic codes that enable the construction of a flag fault-tolerant error correction scheme. We then develop fault-tolerant protocols as well as a family of circuits for flag fault-tolerant error correction and operator measurement, requiring only four ancilla qubits and applicable to cyclic CSS codes of distance 3. The measurement protocol can be further used for logical Clifford gate implementation via quantum gate teleportation. We also provide examples of cyclic CSS codes with large encoding rates.
Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase ζ/β by the yeast substrate-trapping system (2001)

We used a genetic method, the yeast substrate-trapping system, to identify substrates for protein tyrosine phosphatases zeta (PTPzeta/RPTPbeta). This method is based on the yeast two-hybrid system, with two essential modifications: conditional expression of protein tyrosine kinase v-src (active src) to tyrosine-phosphorylate the prey proteins and screening by using a substrate-trap mutant of PTPzeta (PTPzeta-D1902A) as bait. By using this system, several substrate candidates for PTPzeta were isolated. Among them, GIT1/Cat-1 (G protein-coupled receptor kinase-interactor 1/Cool-associated, tyrosine-phosphorylated 1) was examined further. GIT1/Cat-1 bound to PTPzeta-D1902A dependent on the substrate tyrosine phosphorylation. Tyrosine-phosphorylated GIT1/Cat-1 was dephosphorylated by PTPzeta in vitro. Immunoprecipitation experiments indicated that PTPzeta-D1902A and GIT1/Cat-1 form a stable complex also in mammalian cells. Immunohistochemical analyses revealed that PTPzeta and GIT1/Cat-1 were colocalized in the processes of pyramidal cells in the hippocampus and neocortex in rat brain. Subcellular colocalization was further verified in the growth cones of mossy fibers from pontine explants and in the ruffling membranes and processes of B103 neuroblastoma cells. Moreover, pleiotrophin, a ligand for PTPzeta, increased tyrosine phosphorylation of GIT1/Cat-1 in B103 cells. All these results indicate that GIT1/Cat-1 is a substrate molecule of PTPzeta.
Measurement of Minority Carrier Lifetime and Surface Effects in Junction Devices (1955)

The characteristics of junction devices are influenced to a considerable degree by the lifetime of the minority carriers. Accordingly, methods for the measurement of this quantity are of considerable importance. Methods have been described for the measurement of the lifetime of minority carriers when these carriers are produced within the volume of a semiconductor. When the minority carriers are introduced near the surface of a semiconductor the resulting effective lifetime may be determined to a large extent by the nature of the surface. For most junction devices, it is the effective lifetime that is of primary importance. This paper describes a simple method for the measurement of effective lifetimes of injected minority carriers. The measurements may be applied to practical junction structures as, for example, an alloyed junction transistor. Measurements may be made on either completed or partially completed devices. The resulting data are potentially of value as quality controls during the fabrication of transistors and similar devices. In many cases, the effective lifetime is a good indication of the surface conditions, and immediate evaluation of these conditions may be obtained at various stages of device processing. With selected geometries, the measurement method may be applied to determine absolute values of surface recombination velocities and should therefore be in studying surface conditions and treatments. The measurement method is described in terms of junction devices using germanium as the semiconductor. However, the method is equally applicable to junction devices made with other semiconductor materials.
Recent advances in the development of gene delivery systems (2019)

The goal of the research for gene delivery system is to develop the clinically relevant vectors such as viral and non-viral vectors that use to combat elusive diseases such as AIDS, cancer, Alzheimer, etc. Next step research will focus on advancing DNA and RNA molecular technologies to become the standard treatment options in the clinical area of biomedical application.
Compliance Checking of Shipment Request by Utilizing Process Mining Concepts: An Evaluation of Smart Auditing Framework (2017)

Risk regulations and compliance management require business controls automation. Business processes execution yield event logs and analysis of these logs can produce valuable knowledge for organizational product and/or service improvements. In this paper we have explored a monitoring scenario of shipment request and evaluated it on the basis of Smart auditing framework. A combination of process mining techniques and business process ontologies is evaluated on simulated data in order to identify the auditing/monitoring capability of PROM plug-in's. The initial evaluation revealed that rule based audit is successful on machine-crafted data in PROM tool. Moreover, this paper also highlights lack of automated rule translation in LTL-checker (PROM plug-in) for smart audit frameworks evaluations.
Broad-band high-power amplifier using spatial power-combining technique (2003)

High power, broad bandwidth, high linearity, and low noise are among the most important features in amplifier design. The broad-band spatial power-combining technique addresses all these issues by combining the output power of a large quantity of microwave monolithic integrated circuit (MMIC) amplifiers in a broad-band coaxial waveguide environment, while maintaining good linearity and improving phase noise of the MMIC amplifiers. A coaxial waveguide was used as the host of the combining circuits for broader bandwidth and better uniformity by equally distributing the input power to each element. A new compact coaxial combiner with much smaller size is investigated. Broad-band slotline to microstrip-line transition is integrated for better compatibility with commercial MMIC amplifiers. Thermal simulations are performed and an improved thermal management scheme over previous designs is employed to improve the heat sinking in high-power application. A high-power amplifier using the compact combiner design is built and demonstrated to have a bandwidth from 6 to 17 GHz with 44-W maximum output power. Linearity measurement has shown a high third-order intercept point of 52 dBm. Analysis shows the amplifier has the ability to extend spurious-free dynamic range by N/sup 2/3/ times. The amplifier also has shown a residual phase floor close to -140 dBc at 10-kHz offset from the carrier with 5-6-dB reductions compared to a single MMIC amplifier it integrates.
Experimental flux shuttle (1973)

We report the operation of an experimental model of the Josephson junction shift register known as the flux shuttle.
Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases (2012)

Lymphoid neogenesis, or the development of lymphoid structures in nonlymphoid organs, is frequently observed in chronically inflamed tissues, during the course of autoimmune, infectious, and chronic graft rejection diseases, in which a sustained lymphocyte activation occurs in the presence of persistent antigenic stimuli. The presence of such ectopic lymphoid structures has also been reported in primary lung, breast, and germline cancers, but not yet in melanoma. In this study, we observed ectopic lymphoid structures, defined as lymphoid follicles comprising clusters of B lymphocytes and follicular dendritic cells (DC), associated with high endothelial venules (HEV) and clusters of T cells and mature DCs, in 7 of 29 cutaneous metastases from melanoma patients. Some follicles contained germinal centers. In contrast to metastatic lesions, primary melanomas did not host follicles, but many contained HEVs, suggesting an incomplete lymphoid neogenesis. Analysis of the repertoire of rearranged immunoglobulin genes in the B cells of microdissected follicles revealed clonal amplification, somatic mutation and isotype switching, indicating a local antigen-driven B-cell response. Surprisingly, IgA responses were observed despite the nonmucosal location of the follicles. Taken together, our findings show the existence of lymphoid neogenesis in melanoma and suggest that the presence of functional ectopic lymphoid structures in direct contact with the tumor makes the local development of antimelanoma B- and T-cell responses possible.