gebhart/patrepeval huggingface dataset:
[Adoptive immunotherapy and metastasized cancer of the kidney. Regulator effects of interleukin-4 on tumor infiltrating lymphocytes (TIL)]. (1991)

Adoptive immunotherapy is a new therapeutic approach of the treatment of advanced renal cell cancer. Experimental studies have shown that the cells with the highest cytolytic activity are tumor infiltrating lymphocytes (TIL). The effects of interleukin-4 (IL-4) on the expansion, proliferation, phenotype and antitumor activity of TIL were studied. Cultures were obtained from three primary renal tumors and one group of tumor invaded, regional lymph nodes. IL-4 induced a significant increase in lymphocytes expansion and proliferation, but the response was dependent of the concurrent dose of IL-2 in culture. TIL grown in the presence of IL-4 significantly reduced the level of non specific, non MHC restricted antitumor activity while exhibiting no effect on the level of autologous killing. The effects of irradiated autologous tumor stimulation on TIL cultures were also evaluated. Addition of autologous tumor increased expansion and proliferation of all cultures and significantly enhanced levels of autologous killing. IL-4 and autologous tumor stimulation are effective growth factors when used in combination with a lose dose IL-2 regimen and may be of significant benefit in the expansion of TIL for clinical trials.
Interactive consistency in quasi-asynchronous systems (2002)

In order to make a dependable distributed computer system resilient to arbitrary failures of its processors, deterministic interactive consistency algorithms (ICAs) are required. Thus far, in order to guarantee interactive consistency, all ICAs found in the literature require that all correct processors in the system start the algorithm simultaneously. In a distributed system, it is hard to satisfy this requirement. Therefore, in this paper, we describe a new class of self-synchronizing ICAs that guarantee interactive consistency without the above-mentioned requirement.
Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation (2013)

About 8,000 years ago in the Fertile Crescent, a spontaneous hybridization of the wild diploid grass Aegilops tauschii (2n = 14; DD) with the cultivated tetraploid wheat Triticum turgidum (2n = 4x = 28; AABB) resulted in hexaploid wheat (T. aestivum; 2n = 6x = 42; AABBDD). Wheat has since become a primary staple crop worldwide as a result of its enhanced adaptability to a wide range of climates and improved grain quality for the production of baker's flour. Here we describe sequencing the Ae. tauschii genome and obtaining a roughly 90-fold depth of short reads from libraries with various insert sizes, to gain a better understanding of this genetically complex plant. The assembled scaffolds represented 83.4% of the genome, of which 65.9% comprised transposable elements. We generated comprehensive RNA-Seq data and used it to identify 43,150 protein-coding genes, of which 30,697 (71.1%) were uniquely anchored to chromosomes with an integrated high-density genetic map. Whole-genome analysis revealed gene family expansion in Ae. tauschii of agronomically relevant gene families that were associated with disease resistance, abiotic stress tolerance and grain quality. This draft genome sequence provides insight into the environmental adaptation of bread wheat and can aid in defining the large and complicated genomes of wheat species.
Multivalent Binding of p53 to the STAGA Complex Mediates Coactivator Recruitment after UV Damage (2008)

The recruitment of transcriptional coactivators, including histone modifying enzymes, is an important step in transcription regulation. A typical activator is thought to interact with several cofactors, presumably in a sequential manner. The common use of several cofactors raises the question of how activators achieve both cofactor selectivity and diversity. Human STAGA is a multiprotein complex with the acetyltransferase GCN5L as the catalytic subunit. Here, we first show, through RNA interference-mediated knock-down and chromatin immunoprecipitation assays, that GCN5 plays a role in p53-dependent gene activation. We then employ p53 mutagenesis, in vitro binding, protein-protein cross-linking, and chromatin immunoprecipitation assays to establish a novel role for the second p53 activation subdomain (AD2) in STAGA recruitment and, further, to demonstrate that optimal binding of STAGA to p53 involves interactions of STAGA subunits TAF9, GCN5, and ADA2b, respectively, with AD1, AD2, and carboxy-terminal domains of p53. These results provide concrete evidence for mediation of transcription factor binding to coactivator complexes through multiple interactions. Based on our data, we propose a cooperative and modular binding mode for the recruitment of coactivator complexes to promoters.
Correlated pattern mining in quantitative databases (2008)

We study mining correlations from quantitative databases and show that this is a more effective approach than mining associations to discover useful patterns. We propose the novel notion of quantitative correlated pattern (QCP), which is founded on two formal concepts, mutual information and all-confidence. We first devise a normalization on mutual information and apply it to the problem of QCP mining to capture the dependency between the attributes. We further adopt all-confidence as a quality measure to ensure, at a finer granularity, the dependency between the attributes with specific quantitative intervals. We also propose an effective supervised method that combines the consecutive intervals of the quantitative attributes based on mutual information, such that the interval-combining is guided by the dependency between the attributes. We develop an algorithm, QCoMine , to mine QCPs efficiently by utilizing normalized mutual information and all-confidence to perform bilevel pruning. We also identify the redundancy existing in the set of QCPs and propose effective techniques to eliminate the redundancy. Our extensive experiments on both real and synthetic datasets verify the efficiency of QCoMine and the quality of the QCPs. The experimental results also justify the effectiveness of our proposed techniques for redundancy elimination. To further demonstrate the usefulness and the quality of QCPs, we study an application of QCPs to classification. We demonstrate that the classifier built on the QCPs achieves higher classification accuracy than the state-of-the-art classifiers built on association rules.
A Nonlinear Model for the Spatial Characteristics of the Human Visual System (1977)

Several recent papers have presented data from experimental investigations of the human ivsual system (HVS) which support the general hypothesis that the HVS is composed of spatial frequency channels. It has been pointed out, however, that a linear systems analysis of the entire system is not valid. Furthermore, a nonlinear model consisting of a log-bandpass filter produced some experimental results with deviations at high spatial frequencies. A new structure for a nonlinear mathematical model which is easily quantifiable, produces results which compare with experimental data, and has a physiological correlate is presented. The significance of this model is that the bandwidth of the visual system decreases as contrast increases. Thus the system appears to maximize the signal to noise ratio while attempting to maintain a constant " perceptual" spatial-frequency fidelity.
Outcomes for Patients With COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-Analysis (2020)

Kidney dysfunction is common among patients with COVID-19, and patients who develop AKI have inferior outcomes<i>.</i> Additional research into management and potential mechanisms of this association is needed.
Ototoxicity of the antiseptic combination (1986)

Literature concerning the ototoxicity of the antiseptic combination chlorhexidine/cetrimide (Savlon) is reviewed. The ototoxic effects are illustrated by the results of our own experiments in guinea pigs. The impetus for this article was the observation of vestibular dysfunction in 15 clinical cases (12 dogs and 3 cats), in 8 of which it was confirmed that the ear canal had been rinsed with this drug combination in the presence of a ruptured tympanic membrane.
A Methodology for Systems Requirements Specification and Traceability for Large Real Time Complex Systems (1991)

Abstract : This document describes the beginnings of a methodology for requirements specification and traceability of real-time, large-scale, complex computer-intensive systems. The method is aimed at better understanding, the top-level system requirements and how they relate to the system under design. The methodology will cover the requirements aspects of system development over the entire system development life cycle, beginning with the specification of the requirements and tracing those requirements to the design and final implementation.
[Clinical study on treating asthma of cold type with wenyang tongluo mixture]. (1996)

Sixty-eight asthma patients of Cold type were randomly divided into two groups, 34 for each group. The treated group was treated with Chinese herbal medicine Wenyang Tongluo Mixture (WYTLM), the control group was treated with Salbutamol orally and beclomethasone dipropionate aerosol. After 8 weeks of treatment, the results showed that there was no significant difference between the short-term total effective rate of the two groups (P > 0.05). Results of followup 1 year after withdrawal of treatment, showed that 9 patients (26.47%) in the treated group and 2 (5.88%) in the control group were cured clinically, it indicated that the long-term curative rate of the former group was higher than that of the latter group significantly (P < 0.05). And the effect of treated group on eliminating Asthenia-Cold symptoms, improving pulmonary ventilation function, regulating adrenergic beta-receptors of peripheral blood lymphocyte and decreasing the serum level of 5-hydroxytryptamine was more superior to that of control group (P < 0.05-0.01). This study provided some objective basis for using WYTLM in preventing and treating asthma of Cold type.
Analysis of variation of piston temperature with piston dimensions and undercrown cooling (1948)

From Summary: "A theoretical analysis is presented that permits estimation of the changes in piston-temperature distribution induced by variations in the crown thickness, the ring-groove-pad thickness, and the undercrown surface heat-transfer coefficient. The analysis consists of the calculation of operating temperatures at various points in the piston body on the basis of the experimentally determined surface heat-transfer coefficients and boundary-region temperatures, as well as arbitrarily selected surface coefficients."
A Portable Gas Analyzer With Wireless Transmission of Gas Concentrations and GPS Coordinates (2007)

A new 4-channel analyzer (one to four sensors in the unit), the Model 106, was introduced by PID Analyzers in 2005. The Analyzer consists of a readout unit that contains the processor board, 2 line by 16 character display readout, 4 channel by 16 bit ADC wit multiplixer, battery and pump. The Snap On Head contains a 4 or 5 channel amp board, a sensor board sensor caps and tubing. The amplifiers can measure nanoamps, microvolts, potentiomentric, amperometric, or fuel sensors and a Wheatstone bridge can be used for a thermal conductivity, combustible gas or infrared sensors. The user can select from more than 40 different sensors and technologies such as Photo-Ionization Detector (PID), Infrared (IR), ThermalConductivity Detector (TCD), Combustible Gas (CG), capacitance, temperature, and electrochemical sensors. This microprocessor-based analyzer calculates and displays the concentrations on its screen, and it has the capability of logging >7,000 points or automatically. The data can be downloaded to a PC via the RS232 port & the Grapher software that is provided.
Does an immunoscintigraphy with OC 125 affect the prognosis of ovarian cancer? (1997)

In a retrospective study, a total of 120 ovarian cancer patients were paired in terms of staging, grading, patent age, and operative and cytostatic therapy. Half of the patients underwent radioimmunoscintigraphy for diagnostic purposes. From the point of view of possible adjuvant immunological therapy, we investigated to what extent patients with treated ovarian cancer benefit from the application of OC 125 in terms of survival time. In our study we have been able to show that at favorable stages (FIGO II) the patient benefitted more from a radioimmunoscintigraphy than at prognostically unfavorable stages (FIGO IV). Even within FIGO stage III we have been able to show, thanks to the large number of cases, that patients with an NED situation benefitted significantly more form radioimmunoscintigraphy in terms of survival than those with residual tumors. Throughout FIGO stage III, patients with radioimmunoscintigraphy showed significantly superior 5-year survival rates (p < 0.05) than those without radioimmunoscintigraphy. These data would appear to justify prospective studies to establish to what extent ovarian cancer patients benefit from an adjuvant application of OC 125 in terms of the 5-years survival rate and the relapse-free interval.
Die Verminderung des Kobaltgehaltes in Aufschweißlegierungen (1941)

Möglichkeit der Senkung des Kobaltgehaltes in Aufschweißlegierungen mit üblicherweise rd. 1,25% C, 65% Co, 28% Cr und 4% W ohne wesentliche Veränderung der Verschleißfestigkeit, Warmhärte und Korrosionsbeständigkeit. Härte bei Temperaturen bis 700°, Gefüge und Wärmeausdehnung von Legierungen mit 0,75 bis 2,0% C, 0 bis 46,3% Co, 15,6 bis 31,3% Cr, 9,6 bis 65% Fe, 0,4 bis 1,5% Mn, 0 bis 5,1% Mo, 0 bis 10,1% Ni, 1,4 bis 3,7% Si und 3,6 bis 6,6% W. Ausscheidungshärtung der Legierungen. Austausch der üblichen Legierung mit 65% Co durch eine solche mit 19% Co, 28% Cr, 5% Mo und 5% W erscheint gegeben.
Preferential excision of the 5' proximal intron from mRNA precursors with two introns as mediated by the cap structure. (1987)

We have studied the effect of the 5' cap structure on the splicing of precursor mRNAs containing three exons and two introns within a single molecule in a HeLa nuclear extract. When a precursor mRNA was capped, the upstream intron was spliced out more efficiently than the downstream intron. The differential splicing reactions of the two introns are not due to differences in the intrinsic efficiency of splicing of each intron, since the preferential excision of the upstream intron was also observed when the positions of the two introns relative to the cap structure were reversed. When uncapped precursor mRNA was used as substrate, the downstream intron was spliced out appreciably, but splicing of the upstream intron was greatly reduced. Preincubation of the extract with cap analogues inhibited splicing of the upstream intron but not the downstream intron. Thus, the cap structure exerts its effect primarily on the 5' proximal intron.
Toward a Sociology of the Network Society (2000)

The Call to Sociology The twenty-first century of the Common Era did not necessarily have to usher in a new society. But it did. People around the world feel the winds of multidimensional social change without truly understanding it, let alone feeling a grasp upon the process of change. Thus the challenge to sociology, as the science of study of society. More than ever society needs sociology, but not just any kind of sociology. The sociology that people need is not a normative meta-discipline instructing them, from the authoritative towers of academia, about what is to be done. It is even less a pseudo-sociology made up of empty word games and intellectual narcissism, expressed in terms deliberately incomprehensible for anyone without access to a French-Greek
Immunogenicity of vaccines from a virulent and an a virulent strain of Aeromonas salmonicida (1985)

Abstract. Injected vaccines consisting of formalin‐killed cells and extracellular antigens prepared from a virulent and an avirulent strain of Aeromonas salmonicida were tested for their efficacy in protecting juvenile coho salmon. Oncorhychus kisutch (Walbaum). Against experimental furunculosis following active and passive immunization. Sera used in the passive immunization experiments were raised in subadult coho salmon and in rabbits. Results indicated that the avirulent strain was inferior to the virulent strain in its immunogenicity for coho salmon. Thus, even though avirulent cells possessed at least one immunogen–an immunogen that was show in passive immunization experiments to be well recognized by rabbits–the immunogen was only inefficiently protection when vaccinated with avirulent cells. Furher, extracellular antigens of the avirulent strain were not protective for coho salmon even though they elicited the production of anti‐ A. salmonicida agglutinins. In contrast, the killed cells and extracellular antigens of the virulent strain were both immunogenic in coho salmon. By passively immunizing coho salmon with rabbit sera raised against the virulent and the virulent strain produced at least two immunogens, only one of which was shared in common with the avirulent strain. The extra immunogen possessed by the virulent strain is presumably responsible for its superior immunogenicity in coho salmon; the immunogen had the properties of a protein and is believed to be the A‐protein.
Distribution of neurofilament subunits in neurons and neuronal processes: immunohistochemical studies of bovine cerebellum with subunit-specific monoclonal antibodies. (1985)

The distribution of individual neurofilament (NF) subunits in bovine cerebellar neurons was examined using monoclonal antibodies (MAs) raised against bovine NF. MAs with immunochemically defined specificities for one or more NF subunits were used. Seven were specific for the Mr 68,000 NF subunit, five were specific for the Mr 150,000 NF subunit, nine were specific for the Mr 200,000 NF subunit, and 30 recognized both high molecular weight subunits. Fresh bovine cerebellum was fixed and processed by five different protocols and subjected to four different immunohistochemical procedures. MAs from each group stained neuronal perikarya and processes. NF immunoreactivity in Purkinje cells was evaluated in detail. Adjacent Purkinje cell bodies and dendrites exhibited variable NF immunoreactivity to the same MA, ranging from intensely positive to completely negative. Similar variability in axonal staining was not observed. Application of the same MA to tissue subjected to different fixation and/or immunohistochemical protocols also resulted in variability in NF subunit immunoreactivity. We conclude that MAs recognize each of the three NF subunits in neuronal perikarya, axons, and dendrites. Variability in NF subunit immunoreactivity appears to reflect both NF microheterogeneity and fixation-dependent modifications of NF subunits.
Performance Evaluation and Life Testing of the SPT-100 (1993)

A cyclic endurance test of the Russian 1.35 kW Stationary Plasma Thruster SPT-100 is described.
Processing Eddy Current Signals for the Detection of Deep Voids in Copper (2004)

Eddy current (EC) technique for the detection and characterization of deep voids in copper is presented in the paper. Results were obtained using a specially designed muti‐differential deep penetrating probe. The detection ability of the probe was evaluated using a specially designed sandwich specimen. The specimen was designed to simulate voids of different volumes (holes and slots), located in copper at different depths. It has the form of sandwich consisting of three layers: the upper layer simulating given depth, the middle layer consisting voids, and the bottom plate. EC responses of the probes were acquired for a number of artificial voids with different depths and volumes using an automatic scanner. An automatic method for estimating phase angle of an EC pattern is proposed and verified. The method calculates matrix of central moments and its eigenvectors for each EC pattern. It is shown that the detection of 1 mm artificial voids located at the depth of 4 mm is possible at the test frequency of approx. 700 Hz. It appeared that defect characterization is a relatively simple task consisting of two steps, estimating defect depth based on the phase angle of its response, and using EC amplitude for estimating defect cross section.
Synthesis and photocleavage of a new dimeric bis(o-nitrobenzyl) diether tether (2004)

A new photocleavable linker, 4,4'-bis(alkoxymethyl-3,3'-dinitro)biphenyl, is reported that undergoes photolysis at two positions to release two equivalents of primary, secondary, or benzylic alcohol in yields that are higher than those obtained from the analogous monomeric o-nitrobenzyl ethers.
Characterization of vanadium bromoperoxidase from Macrocystis and Fucus: reactivity of vanadium bromoperoxidase toward acyl and alkyl peroxides and bromination of amines (1990)

Vanadium bromoperoxidase (V-BrPO) has been isolated and purified from the marine brown algae Fucus distichus and Macrocystis pyrifera. V-BrPO catalyzes the oxidation of bromide by hydrogen peroxide, resulting in the bromination of certain organic acceptors or the formation of dioxygen. V-BrPO from F. distichus and M. pyrifera have subunit molecular weights of 65,000 and 74,000, respectively, and specific activities of 1580 units/mg (pH 6.5) and 1730 units/mg (pH 6) for the bromination of monochlorodimedone, respectively. As isolated, the enzymes contain a substoichiometric vanadium/subunit ratio; the vanadium content and specific activity are increased by addition of vanadate. V-BrPO (F. distichus, M. pyrifera, and Ascophyllum nodosum) also catalyzes the oxidation of bromide using peracetic acid. In the absence of an organic acceptor, a mixture of oxidized bromine species (e.g., hypobromous acid, bromine, and tribromide) is formed. Bromamine derivatives are formed from the corresponding amines, while 5-bromocytosine is formed from cytosine. In all cases, the rate of the V-BrPO-catalyzed reaction is much faster than that of the uncatalyzed oxidation of bromide by peracetic acid, at pH 8.5, 1 mM bromide, and 2 mM peracetic acid. In contrast to hydrogen peroxide, V-BrPO does not catalyze formation of dioxygen from peracetic acid in either the presence or absence of bromide. V-BrPO also uses phenylperacetic acid, m-chloroperoxybenzoic acid, and p-nitroperoxybenzoic acid to catalyze the oxidation of bromide; dioxygen is not formed with these peracids. V-BrPO does not catalyze bromide oxidation or dioxygen formation with the alkyl peroxides ethyl hydroperoxide, tert-butyl hydroperoxide, and cuminyl hydroperoxide.
Insect-Protected Event DAS-81419-2 Soybean (<i>Glycine max</i>L.) Grown in the United States and Brazil Is Compositionally Equivalent to Nontransgenic Soybean (2015)

The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated.
Yb<sup>3+</sup>-doped double-clad fibers and lasers (2000)

We present results of the research and development of double-clad Yb<SUP>3+</SUP>-doped fibers for high-power fiber lasers. The quality of the fabricated fibers and optimization of reflecting Bragg gratings allowed us to demonstrate fiber lasers with a quantum efficiency close to 90%. These fiber lasers were used in Raman converters emitting at various wavelengths.