gebhart/patrepeval huggingface dataset:
Interactions between Important Regulatory Proteins and Human αB Crystallin (2007)

Protein pin arrays assessed interactions between alphaB crystallin and 12 regulatory proteins, including EGF, FGF-2, IGF-1, NGF-beta, TGF-beta, VEGF, insulin, beta-catenin, caspase-3, caspase-8, Bcl-2, and Bcl-xL, which are important in cellular differentiation, proliferation, signaling, cytoskeletal assembly, and apoptosis. FGF-2, NGF-beta, VEGF, insulin, and beta-catenin had strong interactions with human alphaB crystallin peptides, and the alphaB crystallin interactive sequences for these proteins were identified. The seven remaining proteins (EGF, IGF-1, TGF-beta, caspase-3, caspase-8, BCl-2, and Bcl-xL) did not interact with alphaB crystallin. The alphaB crystallin sequences that interacted with FGF-2, NGF-beta, VEGF, insulin, and beta-catenin overlapped with sequences that selectively interact with partially unfolded proteins, suggesting a common function for alphaB crystallin in chaperone activity and the regulation of cell growth and differentiation. Chaperone assays conducted with full-length alphaB crystallin and synthetic alphaB crystallin peptides confirmed the ability of alphaB crystallin to protect against the aggregation of FGF-2 and VEGF, suggesting that alphaB crystallin protects these proteins against unfolding and aggregation under conditions of stress. This is the first report in which sequences involved in interactions with regulatory proteins, including FGF-2, NGF-beta, VEGF, insulin, and beta-catenin, were identified in a small heat shock protein.
ChemInform Abstract: Catalytic Asymmetric Synthesis (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A developed algorithm for oscillometric blood pressure measurement (2013)

A developed method to measure blood pressure (BP) based on oscillometric theory is presented in this paper. Estimating mean pressure (MP) during inflation is applied to set a suitable occluded pressure of cuff. In order to simplify the hardware, moving window median filter (MWMF) is used to extract oscillation pulses from cuff signal. Then, Gaussian-Fitting Method (GFM) is introduced to fit the curve of oscillation pulse envelope. Finally, systolic pressure (SP) and diastolic pressure (DP) is calculated in two different ways according to the quality of signal, which is decided by a proposed mechanism of signal quality decision using correlation coefficient. Experiments have proved the algorithm with high precision and accuracy BP results.
Transcranial magnetic stimulation for the treatment of seizures (2002)

The effect of TMS on seizure frequency was mild and short lived.
Lineage-specific Gene Expression in the Sea Urchin Embryo (1985)

Within a few days of fertilization, the sea urchin embryo develops into a small differentiated organism consisting of about 1800 cells and capable of feeding, swimming, and the further ontogenic transformations required in the succeeding weeks of larval growth. A number of distinct cell lineages that are clearly specialized at the morphological and functional levels can be discerned in the advanced embryo, and many of these can be traced back to particular sets of early blastomeres. Classical cell lineage and experimental studies (Hörstadius 1939; for review, see Angerer and Davidson 1984) have shown that certain of these lineages appear to be specified, at least in part, in consequence of the maternal components inherited in those regions of egg cytoplasm occupied by their progenitor cells. Specification of others among the early cell lineages clearly depends on inductive interactions that occur between blastomeres during cleavage. For the molecular biologist, as for his predecessors, this rapidly developing and simply constructed embryo offers the advantages of experimental accessibility. Thus, in respect to direct molecular-level analyses of gene activity in the embryo, for both specific genes and overall transcript populations and their protein products, the sea urchin is at present the best known embryonic system (e.g., reviews of Hentschel and Birnstiel 1981; Davidson et al. 1982; Angerer and Davidson 1984).
On the Mechanism of Lithium Insertion into A<sub>2</sub>Ti<sub>6</sub>O<sub>13</sub> (A = Na, Li) (2012)

A combined structural and electrochemical study of the compounds Na 2 Ti 6 O 13 and Li 2 Ti 6 O 13 titanates as anode electrodes for Li-ion batteries is presented. The structural differences between both titanates, where Na and Li atoms are located in an eightfold and [3+1] coordination, respectively, play a crucial role in the electrochemical behavior. Two-dimensional difference Fourier synthesis maps of Li x Na 2 Ti 6 O 13 and Li x Li 2 Ti 6 O 13 using NPD data provide valuable information about the possible reaction mechanism. In the first stages of Li insertion into Na2Ti6O13, Li enters the central tunnel site position (0.5, 0.5, 0.5), whereas the site of truly inserted Li in Li 2 Ti 6 O 13 could not yet be unequivocally assessed. The different electrochemical behavior of Na 2 Ti 6 O 13 and Li 2 Ti 6 O 13 as electrodes in lithium rechargeable batteries is thought to be determined by the structural difference arising from the tunnel alkali metals Na+ and Li+.
Increased Vascular Smooth Muscle Contractility in <i>TRPC6</i><sup>−</sup><sup>/</sup><sup>−</sup> Mice (2005)

Among the TRPC subfamily of TRP (classical transient receptor potential) channels, TRPC3, -6, and -7 are gated by signal transduction pathways that activate C-type phospholipases as well as by direct exposure to diacylglycerols. Since TRPC6 is highly expressed in pulmonary and vascular smooth muscle cells, it represents a likely molecular candidate for receptor-operated cation entry. To define the physiological role of TRPC6, we have developed a TRPC6-deficient mouse model. These mice showed an elevated blood pressure and enhanced agonist-induced contractility of isolated aortic rings as well as cerebral arteries. Smooth muscle cells of TRPC6-deficient mice have higher basal cation entry, increased TRPC-carried cation currents, and more depolarized membrane potentials. This higher basal cation entry, however, was completely abolished by the expression of a TRPC3-specific small interference RNA in primary TRPC6(-)(/)(-) smooth muscle cells. Along these lines, the expression of TRPC3 in wild-type cells resulted in increased basal activity, while TRPC6 expression in TRPC6(-/-) smooth muscle cells reduced basal cation influx. These findings imply that constitutively active TRPC3-type channels, which are up-regulated in TRPC6-deficient smooth muscle cells, are not able to functionally replace TRPC6. Thus, TRPC6 has distinct nonredundant roles in the control of vascular smooth muscle tone.
Laser-assisted chemical vapour deposition of TiSi<sub>2</sub>: aspects of deposition and etching (1993)

Lines of TiSi2 were written on Si(100) substrates by using a focused Ar+-laser. The reaction gas mixture consisted of TiCl4 and H2 and the substrate was used as the silicon source. The laser deposited TiSi2 lines were examined as a function of the deposition parameters. Especially the initial reactions have been studied by varying the the writing speed in a wide range. The C-54 phase of TiSi2 was observed in all experiments. The geometrical shape and the surface profile of the deposited TiSi2 were complicated functions of the process parameters and the growth process itself. Substrate reactions increased the substrate etching initially. After a sufficiently thick layer of TiSi2 had been grown, thus protecting the substrate from the reaction gas mixture, the etch process stopped. By minimizing the initial substrate reactions, flat lines with respect to the substrate surface could be grown.
Fungal and Bacterial Isolation from Inflamed Guttural Pouches; Drug Susceptibility of the Isolates (2000)

An endoscope was used to perform isolations for fungi and bacteria from the guttural pouches of 14 thoroughbred horses. Drug susceptibilities of the isolates were investigated.Emericella nidulansandAspergillus fumigatuswere isolated from 4 horses. Only the former was isolated from 3 horseseuthanized because of terminal prognosis.E. nidulanswas confirmed as the major causative agent ofguttural-pouch mycosis. Since 19 strains of bacteria were isolated from 13 horses, some of which demonstrated mycosis, itwas suggested that bacterial infection is common in cases of mycotic inflammation of the guttural pouch.Drug-susceptibility tests showed miconazole to be the most active antifungal agent (MIC =3.1μg/ml) againstE.nidulans, whereas amikacin and miocycline in combination were most effective against 30 bacterial isolates (100% sensitivity with this combination.) These 3 drugs, therefore, are thought to be useful in antibiotictreatment of equine guttural-pouch infection.
Treatment of Humeral Shaft Fractures with Humeral Locked Nail and Comparison with Plate Fixation (1998)

Humeral locked nailing offered a less invasive surgical technique and more favorable treatment results than did plate fixation. Correct nailing direction, precise surgical techniques, less bulky hardware, and stable transfixing screws are the keys to a successful treatment. Further prospective, randomized comparative study is warranted.
Dormant Mode Host Alerting ("IP Paging") Problem Statement (2001)

This memo describes paging, assesses the need for IP paging, and presents a list of recommendations for Seamoby charter items regarding work on paging.The results are specifically directed toward the task undertaken by the design team, and are not meant to be the definitive word on paging for all time, nor to be binding on Seamoby or other working groups, should the situation with regard to IP mobility protocols or radio link support undergo a major change.
Low voltage comparator for high speed ADC (2010)

This paper presents a design of a high-speed, low-voltage, low power consumption comparator with S-R latch for High speed ADC. The comparator is the most important part in the Flash ADC, since the speed and the resolution is determined by the comparator. In this paper, we do the analysis of the traditional comparator and propose a better structure combing sense amplifier and symmetric S-R latch, which can run faster and provide more stable output signal than the traditional structure. The comparator is composed of a latch based amplifier and a S-R latch which provides stable output. There are many issues in the design of the comparator, we will discuss those design issues in this paper.
ORG 10172: a low molecular weight heparinoid anticoagulant with a long half‐life in man. (1987)

ORG 10172 is a heparinoid with mean molecular weight 6500 daltons. Intravenous bolus injections of ORG 10172 were compared with placebo and heparin injections in 91 separate studies in 83 healthy male subjects. 6400 units ORG 10172 produced a mean maximum change of 14.7 s in kaolin cephalin time (c.f. greater than 120 s for 5000 units heparin). Changes in prothrombin time were minimal (1.6 s for 6400 units ORG 10172 and 4.5 s after 5000 units heparin). A dose-related increase in bleeding time occurred after ORG 10172 and at high doses (greater than 3200 units) some secondary bleeding, which was never serious, occurred at between 1 and 4 h after incision. A dose-dependent reduction in ex vivo platelet adhesiveness was found at 10 min after ORG 10172 injection. ORG 10172 promoted a much smaller release of lipoprotein lipase as compared with heparin. The effect of ORG 10172 on plasma factor Xa activity (one measure of its action) was described by a biexponential decay with a mean distribution half-life of 2.34 (s.e. mean 0.16) h and mean disposition half-life of 17.6 (s.e. mean 1.1) h. It thus has a much longer duration of effect than heparin. There was a linear relationship of plasma anti-Xa response to increasing dose although there was some variability only partly explained by differences in body weight or surface area. ORG 10172 administration by bolus intravenous injection was well tolerated and there was no evidence of adverse effects on clinical chemistry or haematology tests.
Estimation of Triphosphoric and Pyrophosphoric Acids in Presence of Ortho- and Metaphosphoric Acids (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEstimation of Triphosphoric and Pyrophosphoric Acids in Presence of Ortho- and Metaphosphoric AcidsR. N. BellCite this: Anal. Chem. 1947, 19, 2, 97–100Publication Date (Print):February 20, 1947Publication History Published online1 May 2002Published inissue 20 February 1947https://pubs.acs.org/doi/10.1021/ac60002a008https://doi.org/10.1021/ac60002a008research-articleACS PublicationsRequest reuse permissionsArticle Views180Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Heterocyst Pattern Formation Controlled by a Diffusible Peptide (1998)

Many filamentous cyanobacteria grow as multicellular organisms that show a developmental pattern of single nitrogen-fixing heterocysts separated by approximately 10 vegetative cells. Overexpression of a 54-base-pair gene, patS, blocked heterocyst differentiation in Anabaena sp. strain PCC 7120. A patS null mutant showed an increased frequency of heterocysts and an abnormal pattern. Expression of a patS-gfp reporter was localized in developing proheterocysts. The addition of a synthetic peptide corresponding to the last five amino acids of PatS inhibited heterocyst development. PatS appears to control heterocyst pattern formation through intercellular signaling mechanisms.
Obtaining More Precise Descriptions of Peats by Use of Oriented Microtome Sections (1983)

A procedure is described for making relatively undistorted, oriented microtome sections of peat for microscopic analysis. This simple procedure results in a permanent sample from which data can be produced that are precise, statistically reproducible, and easily transmitted and compared with data from other sources. Highly accurate fiber-to-matrix ratios, porosities, and mineral contents can be quickly and easily determined from area point-counts of these peat sections. The terms fibric, hemic, and sapric, which have been widely used in the United States for describing peats, can be very precisely applied to peat samples in which fiber contents are determined in this way. Color and translucency of peatified tissues can be measured from unstained microtome sections; or microtome sections may be differentially stained to bring out chemical or physical difference between tissues at different levels. Optical birefringence and fluorescence are two characteristics of peat tissues which can also be accurately measured. Both can be related to source substances and degree of decomposition. This microtome sectioning technique has been used to describe and classify peats from the Everglades-Mangrove Region of Florida, the Okefenokee Swamp of Georgia, the Snuggedy Swamp of South Carolina, and the Albemarle-Pamlico Peninsular Swamps of North Carolina. The technique worked equally well on peats ranging in physical characteristics from coarsely-fibrous or woody (fibric) to finely-granular (sapric).
High nontransferrin bound iron levels and heart disease in thalassemia major (2008)

Although the presence of nontransferrin bound plasma iron (NTBI) in transfusional iron overload is well documented, knowledge about its clinical significance is limited. We assessed NTBI levels in a large and homogeneous series of thalassemia patients on regular transfusion and chelation and explored the hypothesis that NTBI levels may be associated with relevant clinical outcomes: in particular, heart disease. Among 174 patients with thalassemia major and intermedia, we showed the presence NTBI in 145 of 174 or 83.3% of cases. NTBI levels correlated with transferrin saturation, age, and ALT, and not with serum ferritin or liver iron concentrations. At a multiple regression analysis, transferrin saturation and heart disease but not age was independent predictors of NTBI. Patients with heart disease had NTBI levels significantly higher than those without. All patients with heart disease had transferrin saturation above 70%, and all were NTBI positive. Conversely, none of the patients without NTBI and/or with transferrin saturation less than 70% had preclinical or clinical heart disease. To our knowledge, this is the first documentation of a link between the presence of NTBI in thalassemic patients with transfusional iron overload and heart disease. Further investigation from these preliminary findings may clarify whether NTBI assessment may have a role in evaluating the risks and optimizing treatment for transfusion-dependent patients.
Advanced Deepwater Monitoring System (2013)

This study investigates new methods to improve deepwater monitoring and addresses installation of advanced sensors on “already deployed” risers, flowlines, trees, and other deepwater devices. A major shortcoming of post installed monitoring systems in subsea is poor coupling between the sensor and structure. This study provided methods to overcome this problem. Both field testing in subsea environments and laboratory testing were performed. Test articles included actual flowline pipe and steel catenary risers up to twenty-four inches in diameter. A monitoring device resulting from this study can be installed in-situ on underwater structures and could enhance productivity and improve safety of offshore operations. This paper details the test results to determine coupling methods for attaching fiber optic sensor systems to deepwater structures that have already been deployed. Subsea attachment methods were evaluated in a forty foot deep pool by divers. Afterword, structural testing was conducted on the systems at the NASA Johnson Space Center. Additionally a 7,000 foot deep sensor station was attached to a flowline with the aid of a remote operated vehicle. Various sensor to pipe coupling methods were tested to measure tensile load, shear strength and coupling capability. Several adhesive bonding methods in a subsea environment were investigated and subsea testing yielded exceptionally good results. Tensile and shear properties of subsea application were approximately 80 percent of those values obtained in dry conditions. Additionally, a carbide alloy coating was found to increase the shear strength of metal to metal clamping interface by up to 46 percent. This study provides valuable data for assessing the feasibility of developing the next generation fiber optic sensor system that could be retrofitted onto existing subsea pipeline structures.
What Role Does the Route of Immunization Play in the Generation of Protective Immunity against Mucosal Pathogens? (2009)

The route of vaccination is important in influencing immune responses at the initial site of pathogen invasion where protection is most effective. Immune responses required for mucosal protection can differ vastly depending on the individual pathogen. For some mucosal pathogens, including acute self-limiting infections, high-titer neutralizing Abs that enter tissue parenchyma or transude into the mucosal lumen are sufficient for clearing cell-free virus. However, for pathogens causing chronic infections such as HIV, hepatitis C virus, herpes viruses, mycobacteria, and fungal and parasitic infections, a single arm of the immune response generated by systemic vaccination may be insufficient for protection. Induction of the mucosal innate and adaptive immune systems, including CD4+ T help, Th17, high avidity CD8+ CTL, and secretory IgA and IgG1 neutralizing Abs, at the site of pathogen entry may be required for effective protection against highly invasive pathogens that lead to chronic infection and may be generated predominantly by mucosal vaccination.
Tailoring Wavelets for Chaos Control (2002)

Chaos is a class of ubiquitous phenomena and controlling chaos is of great interest and importance. In this Letter, we introduce wavelet controlled dynamics as a new paradigm of dynamical control. We find that by modifying a tiny fraction of the wavelet subspaces of a coupling matrix, we could dramatically enhance the transverse stability of the synchronous manifold of a chaotic system. Wavelet controlled Hopf bifurcation from chaos is observed. Our approach provides a robust strategy for controlling chaos and other dynamical systems in nature.
A Consumer Behavior Based Approach to Multi-Stage EV Charging Station Placement (2015)

This paper presents a multi-stage approach to the placement of charging stations under the scenarios of different electric vehicle (EV) penetration rates. The EV charging market is modeled as the oligopoly. A consumer behavior based approach is applied to forecast the charging demand of the charging stations using a nested logit model. The impacts of both the urban road network and the power grid network on charging station planning are also considered. At each planning stage, the optimal station placement strategy is derived through solving a Bayesian game among the service providers. To investigate the interplay of the travel pattern, the consumer behavior, urban road network, power grid network, and the charging station placement, a simulation platform (The EV Virtual City 1.0) is developed using Java on Repast.We conduct a case study in the San Pedro District of Los Angeles by importing the geographic and demographic data of that region into the platform. The simulation results demonstrate a strong consistency between the charging station placement and the traffic flow of EVs. The results also reveal an interesting phenomenon that service providers prefer clustering instead of spatial separation in this oligopoly market.
Pulmonary aspergilloma—clinical immunology (1973)

Summary Twenty‐eight selected patients with pulmonary aspergilloma and many with respiratory symptoms were investigated. Their atopic status was evaluated and immunological reactivity to extracts of A. fumigatus studied by means of skin, serological and inhalation challenge tests. The findings suggested that immunological mechanisms may have played a role in producing symptoms in 75% of these patients. Based on these findings, corticosteroids may have a place in treatment of some patients with pulmonary aspergilloma. Care in the use of corticosteroids is recommended because of the prevalence of bacterial infection. Suggestions are offered for selecting patients likely to respond to corticosteroid drugs.