gebhart/patrepeval huggingface dataset:
Protein phosphatase 1H, overexpressed in colon adenocarcinoma, is associated with CSE1L (2008)

In search for a new anticancer drug target, we explored genes involved in colon adenocarcinoma development through dysregulation of a signal transduction pathway. By using the gene expression profile database, we found protein phosphatase 1H (PPM1H), belonging to the protein phosphatase 2C (PP2C) family, upregulated in colon adenocarcinomas compared with normal colon tissues. RT-PCR analysis verified the elevated level of PPM1H expression in colon cancer cell lines relative to a normal colon cell line. PPM1H encodes a protein with a molecular mass of approximately 50 kDa that resides in the cytoplasm. PPM1H fused with maltose-binding protein expressed in E. coli exhibited phosphatase activity characteristic of the PP2C family. Co-immunoprecipitation coupled with mass spectrometry analysis identified CSE1L, a proliferation and apoptosis-related protein, as a PPM1H-interacting protein. Native, but not inactive, PPM1H expressed in HeLa cells increased the mobility of CSE1L on SDS gels and a similar mobility shift was observed for purified CSE1L after treatment with PPM1H in vitro, supporting the notion that CSE1L is a substrate of PPM1H. Dominant negative PPM1H protected HeLa cells from cell death triggered by staurosporine or taxol. Additionally, knockdown of PPM1H expression with small interfering RNAs suppressed the growth of MCF-7 cells weakly but consistently. PPM1H controls cell cycle and proliferation of cancer cells potentially through dephosphorylation of CSE1L and might be a new target of anticancer drugs.
<italic>GMR Stirling Thermal Engine</italic> part of the Stirling engine story-1960 chapter (1960)

<div class="section abstract"><div class="htmlview paragraph">THIS PAPER discusses the Stirling thermal enging from four points of view: <ol class="list nostyle"> <li class="list-item"> <span class="li-label">1.</span> <div class="htmlview paragraph">The ideal, thermodynamic point of view, showing the inherent potentialities of the ideal Stirling cycle in comparison to the basic cycles of other engines.</div></li> <li class="list-item"> <span class="li-label">2.</span> <div class="htmlview paragraph">The physical engine and its method of operation with respect to the ideal cycle and the limitations of practical mechanics.</div></li> <li class="list-item"> <span class="li-label">3.</span> <div class="htmlview paragraph">Performance data from the first modern Stirling engines ever operated in the United States, evaluating the relationship between the new engine and other more familiar engines of similar sizes. This comparative discussion serves to demonstrate the advantages and disadvantages of the Stirling engine and to indicate its proper place in the 1960 family of prime movers.</div></li> <li class="list-item"> <span class="li-label">4.</span> <div class="htmlview paragraph">A look backward into the century of history behind the modern engine pointing out significant milestones in the engine's development. Particular attention is paid to Stirling's work, to the engine's American history, and to the significant, recent developments that were instrumental in producing the new Stirling engine<span class="xref">*</span></div></li></ol></div></div>
Dopamine D<sub>3</sub>Receptor Agonist Delivery to a Model of Parkinson's Disease Restores the Nigrostriatal Pathway and Improves Locomotor Behavior (2006)

The presence of endogenous stem cell populations in the adult mammalian CNS suggests an innate potential for regeneration and represents a potential resource for neuroregenerative therapy aimed at the treatment of neurodegenerative disorders, such as Parkinson's disease. However, it is first necessary to examine the microenvironmental signals required to activate these innate reparative mechanisms. The small molecule neurotransmitter dopamine has been shown to regulate cell cycle in developing and adult brain, and the D3 receptor is known to play an important role in dopaminergic development. Pharmacological activation of the dopamine D3 receptor has been shown to trigger neurogenesis in the substantia nigra of the adult rat brain. Here, we examined the cell proliferative, neurogenic, and behavioral effects of the dopamine D3 receptor agonist 7-OH-DPAT (7-hydroxy-N,N-di-n-propyl-2-aminotetralin) in a 6-hydroxydopamine model of Parkinson's disease. Consistent with previous findings, we observed a significant induction of cell proliferation in the substantia nigra pars compacta (SN(C)) with a time-dependent adoption of a neuronal dopaminergic phenotype in many of these cells. Indices of nigrostriatal integrity were also affected. Dopaminergic cell counts in the lesioned SN(C) recovered substantially in a time-dependent manner. Similarly, retrograde tracing revealed a restoration of striatal innervation from these cells, with evidence for projections arising from newly generated cells. Finally, we observed a substantial and persistent recovery of locomotor function in these animals. The results of these studies will further our understanding of the environmental signals regulating neurogenesis in the adult brain and could have significant implications for the design of novel treatment strategies for Parkinson's disease.
Multiwavelength optical networks with limited wavelength conversion (1998)

This paper proposes optical wavelength division multiplexed (WDM) networks with limited wavelength conversion that can efficiently support lightpaths (connections) between nodes. Each lightpath follows a route in a network and must be assigned a channel on each link along the route. The load /spl lambda//sub max/ of a set of lightpaths is the maximum over all links of the number of lightpaths that use the link. At least /spl lambda//sub max/ wavelengths will be needed to assign channels to the lightpaths. If the network has full wavelength conversion capabilities, then /spl lambda//sub max/ wavelengths are sufficient to perform the channel assignment. Ring networks with fixed wavelength conversion capability within the nodes are proposed that can support all lightpath sets with load /spl lambda//sub max/ at most W-1, where W is the number of wavelengths in each link. Ring networks with a small additional amount of wavelength conversion capability within the nodes are also proposed that allow the support of any set of lightpaths with load /spl lambda//sub max/ at most W. A star network is also proposed with fixed wavelength conversion capability at its hub node that can support all lightpath sets with load /spl lambda//sub max/ at most W. These results are extended to tree networks and networks with arbitrary topologies. This provides evidence that significant improvements in traffic-carrying capacity can be obtained in WDM networks by providing very limited wavelength conversion capability within the network.
S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer. (2014)

Breast cancer is the second-leading cause of oncology-related death in US women. Of all invasive breast cancers, patients with tumors lacking expression of the estrogen and progesterone hormone receptors and overexpression of human epidermal growth factor receptor 2 have the poorest clinical prognosis. These referred to as triple-negative breast cancer (TNBC) represent an aggressive form of disease that is marked by early-onset metastasis, high tumor recurrence rate, and low overall survival during the first three years post-diagnosis. In this report, we discuss a novel model of early-onset TNBC metastasis to bone and lungs, derived from MDA-MB-231 cells. Breast cancer cells injected intravenously produced rapid, osteolytic metastases in long bones and spines of athymic nude mice, with concurrent metastasis to lungs, liver, and soft tissues. From the bone metastases, we developed a highly metastatic luciferase-tagged cell line variant named MDA-231-LUC Met. In this report, we demonstrate that the Akt/mTOR/S6K1 axis is hyperactivated in these cells, leading to a dramatic increase in phosphorylation of S6 ribosomal protein at Ser235/236. Lastly, we provide evidence that inhibition of the furthest downstream kinase in the mTOR pathway, S6K1, with a highly specific inhibitor PF-4708671 inhibits cell migration, and thus may provide a potent anti-metastatic adjuvant therapy approach.
Metamaterial endoscope for magnetic field transfer: near field imaging with magnetic wires (2003)

We report on the development and use of a highly anisotropic magnetic metamaterial for near-field imaging. The material consists of an array of Swiss Roll structures, resonant near 21.3 MHz, with a peak value of relative permeability ~35. At this peak, the material transfers an input magnetic field pattern to the output face without loss of intensity and with a spatial resolution equal to the roll diameter. It behaves as a near-field imaging device consisting of a bundle of magnetic wires.
ACUSAÇÃO OU FICÇÃO? ABRINDO UMA CLAREIRA NA OPINIO DELICTI COM A VERDADE HERMENÊUTICA (2009)

Neste artigo pretende-se uma aproximação ao conceito de opinio delicti sob a perspectiva da hermenêutica filosófica de Hans-Georg Gadamer, a fim de desvelar o sentido mítico da atividade acusatória do Estado que leva em consideração a razão-em-si-e-por-si-mesma, fruto de convicção (a)histórica e atemporal do órgão acusador (Ministério Público) construída através do método. Somente a partir deste desvelamento conceitual é que será possível a reinserção do homem-acusador na história e, conseqüentemente, a devida “filtragem constitucional da acusação” (à qual denominamos “razão acusatória emancipatória”).
A New Method for Moving Object Tracking With Multi-robot (2011)

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Time Estimation and Aging: A Comparison between Young and Elderly Adults (2001)

Studies about effects of aging on the estimation of short temporal intervals are not conclusive. The aim of the present research was to evaluate age-related differences in the reproduction of a short interval (10 s) using a computerized method. The sample comprised thirteen young adults (M = 26.15 years) and twelve elderly adults (M= 79.1 years). Three parameters of time estimation were measured: estimated time, absolute error, and standard deviation. Results showed that time estimates performed by elderly participants were shorter than those of younger ones, although there were no significant differences between the two age groups in the percentage of absolute errors or standard deviations. These findings could be explained by changes in the rate of the internal clock or to an interaction between more general changes in cognitive processes.
A Random Walk Based Model Incorporating Social Information for Recommendations (2012)

Collaborative filtering (CF) is one of the most popular approaches to build a recommendation system. In this paper, we propose a hybrid collaborative filtering model based on a Makovian random walk to address the data sparsity and cold start problems in recommendation systems. More precisely, we construct a directed graph whose nodes consist of items and users, together with item content, user profile and social network information. We incorporate user's ratings into edge settings in the graph model. The model provides personalized recommendations and predictions to individuals and groups. The proposed algorithms are evaluated on MovieLens and Epinions datasets. Experimental results show that the proposed methods perform well compared with other graph-based methods, especially in the cold start case.
LIQUID GOLD MINE (2007)

RETURN TO ISSUEPREVNewsNEXTLIQUID GOLD MINEScientists in NORWAY are plumbing the seas for the next blockbuster medicineLISA M. JARVISView Author Information C&EN NORTHEAST NEWS BUREAUCite this: Chem. Eng. News 2007, 85, 41, 22–28Publication Date (Print):October 8, 2007Publication History Published online29 October 2010Published inissue 8 October 2007https://pubs.acs.org/doi/10.1021/cen-v085n041.p022https://doi.org/10.1021/cen-v085n041.p022newsACS PublicationsCopyright © 2007 AMERICAN CHEMICAL SOCIETYArticle Views12Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Gold,Liquids,Natural resources,Planets Get e-Alerts
MegaNatural <sup>®</sup> Gold Grapeseed Extract: <i>In Vitro</i> Antioxidant and <i>In Vivo</i> Human Supplementation Studies (2001)

Epidemiological studies have produced solid evidence that consumption of fruits results in a reduction of cancer and cardiovascular disease. Red wine has been hypothesized to reduce the risk of heart disease as a result of its antioxidant, endothelial relaxation, and antiplatelet aggregation mechanisms. We investigated a commercial California wine grapeseed extract, MegaNatural((R)) Gold, and compared it to grapes, grape juice, red wine, other grapeseed extracts, and commercial extracts with respect to antioxidant activity, using an oxidation-reduction colorimetric assay. The quality of the antioxidants was determined with the use of an in vitro model of heart disease, a dose-response inhibition of low-density lipoprotein oxidation. MegaNatural((R)) Gold had a superior quantity/quality antioxidant index compared with all other samples tested. In nine subjects given 600 mg of MegaNatural((R)) Gold, the plasma antioxidant activity as measured by the RANDOX assay was significantly increased by 12% after both 1 and 2 hours. This was equivalent to drinking 300 ml of red wine or consuming 1,250 mg of vitamin C, as found in a previous study. We then determined the dose-response human plasma bioavailability of one of the polyphenols in MegaNatural((R)) Gold (epicatechin) in nine human subjects after giving 200 and 300 mg of the product. The in vivo antioxidant activity was also measured. The higher dose was much more effective. A long-term human supplementation study with 2 x 300 mg/day of MegaNatural((R)) Gold was then done on 17 (9 normal and 8 hypercholesterolemic) subjects. Plasma cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol concentrations were significantly decreased in the subjects with high cholesterol. Triglycerides were significantly increased in the high-cholesterol subjects but were still in the normal range after supplementation. Plasma antioxidant capacity was significantly improved in the high-cholesterol subjects. There was no change in plasma lipids or antioxidant capacity in the normal subjects.
Alkyne isomerization reagents: mixed alkali metal amides (1984)

Addition of sodium and potassium alkoxides, particularly potassium tert-butoxide, to the lithium salts of either 1,2-diaminoethane or 1,3-diaminopropane afford alkyne isomerization reagents that effect triple bond migration to the end of a methylene chain under milder conditions and in higher yield than do previously reported reagents.
Integration of Mesh Optimization with 3D All-Hex Mesh Generation, LDRD Subcase 3504340000, Final Report (1999)

In an attempt to automatically produce high-quality all-hex meshes, we investigated a mesh improvement strategy: given an initial poor-quality all-hex mesh, we iteratively changed the element connectivity, adding and deleting elements and nodes, and optimized the node positions. We found a set of hex reconnection primitives. We improved the optimization algorithms so they can untangle a negative-Jacobian mesh, even considering Jacobians on the boundary, and subsequently optimize the condition number of elements in an untangled mesh. However, even after applying both the primitives and optimization we were unable to produce high-quality meshes in certain regions. Our experiences suggest that many boundary configurations of quadrilaterals admit no hexahedral mesh with positive Jacobians, although we have no proof of this.
A unified mobility model for device simulation (2002)

A physics-based analytical model is presented that unifies the descriptions of majority and minority carrier mobility and that includes screening of the impurities by charge carriers, electron-hole scattering, clustering of impurities, and the full temperature dependence of both majority and minority carrier mobility. The electron and hole mobilities are given as analytical functions of local variables: ionized donor, ionized acceptor, electron and hole concentrations, and the temperature. The excellent agreement between the proposed model and published experimental data on the carrier mobility in silicon reinforces the model predictions on less investigated aspects of the mobility, e.g. the temperature dependence of the minority carrier mobility, which is distinctly different from that of the majority carrier mobility. >
Meta-Analysis of Fluid Requirements for Burn Injury 1980–2002 (2003)

Journal Article Meta-Analysis of Fluid Requirements for Burn Injury 1980–2002 Get access A. Shah, MD, A. Shah, MD 1University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX Search for other works by this author on: Oxford Academic Google Scholar G. C. Kramer, PhD, G. C. Kramer, PhD 1University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX Search for other works by this author on: Oxford Academic Google Scholar J. J. Grady, PH, J. J. Grady, PH 1University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX Search for other works by this author on: Oxford Academic Google Scholar D. N. Herndon, MD, FACS D. N. Herndon, MD, FACS 1University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX Search for other works by this author on: Oxford Academic Google Scholar The Journal of Burn Care & Rehabilitation, Volume 24, Issue suppl_2, March-April 2003, Page S118, https://doi.org/10.1097/00004630-200303002-00152 Published: 01 March 2003
Le vocabulaire franco-anglo-allemand de géomorphologie, de M. Henri Baulig (1957)

Dresch Jean. Le vocabulaire franco-anglo-allemand de géomorphologie, de M. Henri Baulig. In: Annales de Géographie, t. 66, n°355, 1957. pp. 252-253.
Electrophilic Substitution at Saturated Carbon. XXXI. Effects of Attached Second-Row Elements on the Rates of Nitrogen Inversion in Aziridines (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrophilic Substitution at Saturated Carbon. XXXI. Effects of Attached Second-Row Elements on the Rates of Nitrogen Inversion in AziridinesF. A. L. Anet, Robert D. Trepka, and Donald J. CramCite this: J. Am. Chem. Soc. 1967, 89, 2, 357–362Publication Date (Print):January 1, 1967Publication History Published online1 May 2002Published inissue 1 January 1967https://doi.org/10.1021/ja00978a033RIGHTS & PERMISSIONSArticle Views250Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (695 KB) Get e-Alerts Get e-Alerts
Laboratory and clinical characteristics of attenuated strains of influenza virus. (1969)

Prior to 1967, attenuation of influenza virus was achieved by gradually lowering the incubation temperature until optimal growth at 25 degrees C was obtained. The process of attenuation of a Hong Kong strain was modified and considerably shortened. The temperature of incubation was changed abruptly from 35 degrees C to 25 degrees C and a cold variant was selected using the plaque-assay system.A set of genetic markers was developed for assessing the potential virulence of cold-passaged variants. The cold variant of the Hong Kong strain was temperature-sensitive, acid-labile and produced a small plaque in primary chick kidney cells incubated at 35 degrees C. Additional differentiating biological properties relating to the adaptation of the virus to growth at 25 degrees C and to loss of virulence in a susceptible host are presented.The cold-adapted variant was found to be relatively avirulent and highly antigenic for mice and ferrets, and virus was recovered from the nasopharynx of infected ferrets during the first 3 days. The virus recovered was still unable to grow well at 41 degrees C (rct/41-), was sensitive to acid pH and produced small plaques at 35 degrees C and larger ones at 25 degrees C.After a series of plaque purifications, the cold variant showed further loss of virulence to mice, more vigorous growth at 25 degrees C, complete failure to grow at 41 degrees C and good antigenic potency.The genetic markers were stable in the plaque-purified cold variant after at least 10 consecutive passages either in tissue culture at 35 degrees C, or in mice.Cold variants of type B influenza virus have a narrower range of temperature sensitivity compared with type A strains. Reduced plaquing efficiency and reproductive capacity occurred at 35 degrees C (rct/35-) with the attenuated type B strains instead of at 41 degrees C as with the type A strains.Clinical trials with the attenuated Hong Kong strain of influenza virus (A2/Aichi/2/68) have demonstrated the acceptability and immunogenicity of the strain in man.
Self-assembly of engineered protein nanocages into reversible ordered 3D superlattices mediated by zinc ions (2019)

Fabrication of ordered assemblies with protein nanocages as building blocks has attracted great attention. Here, we re-engineered the exterior surface of the smallest natural nanocage, DNA-binding protein from starved cells (Dps), to yield a highly ordered architecture triggered by zinc ions. The resulting architecture possesses a bcc superstructure, the assembly and disassembly of which are reversible and can be regulated by the salt concentration.
Radon-222 concentration measurements in soil using liquid scintillation and Track Etch. (1985)

To determine the health risks of Rn in residential dwellings, the first step may be a widespread Rn monitoring program. If analysis of soil for Rn exhalation from soil was to be part of a large-scale project, a simple method requiring minimal time would be necessary. The present methods of measuring exhalation from soil are time consuming, or require special equipment. The authors technique of using liquid scintillation counting for analysis of soil would allow one technician to analyze more than 100 samplers per week. Analysis of soil from 12 Maine homes using liquid scintillation counting was compared with in situ measurements of Rn concentration in soil and basement air using etched tracked detectors.