gebhart/patrepeval huggingface dataset:
FMCW-LIDAR with tunable twin-guide laser diode (1994)

The realisation of a coherent frequency modulated continuous wave LIDAR used for the accurate measurement of short distances employing a tunable twin-guide laser diode is demonstrated for the first time. A relative accuracy of distance measurement of 4×10-3 has been achieved at a distance of some centimetres.
Environmental stress cracking resistance of polyethylene: The use of CRYSTAF and SEC to establish structure–property relationships (2000)

Nineteen commercial high-density polyethylene resins made with different polymerization processes and catalyst types were analyzed by high-temperature size exclusion chromatography and crystallization analysis fractionation. The information obtained with these characterization techniques on the polymer chain structure was correlated to environmental stress cracking resistance. Environmental stress cracking resistance increases when the molecular weight and concentration of polymer chains that crystallize in trichlorobenzene between 75 and 85 °C increase. Polymer chains present in this crystallization range are assumed to act as tie molecules between crystal lamellae. © 2000 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 38: 1267–1275, 2000
Proceedings of the 29th Annual Symposium on User Interface Software and Technology (2016)

We are very excited to welcome you to the 29th Annual ACM Symposium on User Interface Software and Technology (UIST), held from October 16-19th 2016, in Tokyo, Japan. UIST is the premier forum for the presentation of research innovations in the software and technology of human-computer interfaces. Sponsored by ACM's special interest groups on computer-human interaction (SIGCHI) and computer graphics (SIGGRAPH), UIST brings together researchers and practitioners from diverse areas including graphical & web user interfaces, tangible & ubiquitous computing, virtual & augmented reality, multimedia, new input & output devices, fabrication, wearable computing and CSCW. UIST 2016 received 384 technical paper submissions. After a thorough review process, the 42- member program committee accepted 79 papers (20.6%). Each anonymous submission that entered the full review process was first reviewed by three external reviewers, and a meta-review was provided by a program committee member. If, after these four reviews, the submission was deemed to pass a rebuttal threshold, a second member of the program committee was asked to review the paper and we then asked the authors to submit a short rebuttal addressing the reviewers' concerns. The program committee met in person in Seattle, Washington, USA on June 23rd and 24th, 2016, to select the papers to invite for the program. Submissions were accepted only after the authors provided a final revision addressing the committee's comments. In addition to papers, our program includes 29 posters, 52 demonstrations, and 8 student presentations in the twelfth annual Doctoral Symposium. Our program also features the eighth annual Student Innovation Contest -- teams from all over the world will compete in this year's contest, which focuses on the development of new haptic sensations using Electrical Muscle Stimulation. UIST 2016 will feature two keynote presentations. The opening keynote will be given by Takeo Kanade (Carnegie Mellon University) on new computer-vision technology combining a projector and camera. Naoto Fukasawa (Naoto Fukasawa Design) will deliver the closing keynote on product design. We welcome you to Tokyo, a city of rich tradition and vibrant modern culture. We hope that you will find the technical program interesting and thought-provoking. We also hope that UIST 2016 will provide you with enjoyable opportunities to engage with fellow researchers from both industry and academia, from institutions around the world.
Preimplantation embryology (1996)

Human preimplantation embryos, gametes and cumulus cells were studied for expression of the complement-binding proteins CD46 (membrane cofactor protein), CD55 (decay accelerating factor) and CD59 (membrane attack complex inhibitory factor) as well as complement receptors type 1 (CRI), type 2 (CR2) and type 3 (CR3). Both the CD55 and CD59 glycosyl phosphatidylinositol (GPI)-anchored proteins were expressed by the plasma membrane and zona pellucida of oocytes, early embryos and expanded preimplantation blastocysts; in contrast, CD46 was expressed only on the plasma membrane. Cumulus cells consistently expressed CD46 and, most strongly, CD59 whereas CD55 expression was variable. Monoclonal antibodies (mAbs) to CRI, CR2 and CR3 epitopes gave only occasional reactivity on oocytes and were unreactive with blastocysts, spermatozoa and cumulus cells. CD46 is expressed only on the spermatozoal inner acrosomal membrane, and CD59 on the plasma membrane; CD55 expression was confirmed on the plasma membrane as well as the inner acrosomal membrane. Control mAbs specific for factor H were usually unreactive with gametes, blastocysts and cumulus cells. These data support the concept that gametes and early embryonic cells are protected from complement-mediated attack by expression of CD46, CD55 and CD59, although these complement-binding proteins may have additional roles in reproductive events.
EZH2 and Histone 3 Trimethyl Lysine 27 Associated with Il4 and Il13 Gene Silencing in TH1 Cells (2005)

Differentiation of naïve CD4 T cells toward the T helper 1 (T(H)1) and T helper 2 (T(H)2) fates involves the transcriptional repression and enhancement, respectively, of Il4 and Il13, adjacent chromosome 11 genes encoding the canonical T(H)2 cytokines interleukin-4 and interleukin-13. Proper execution of this developmental fate choice during immune responses is critical to host defense and, when misregulated, leads to susceptibility to infectious microbes and to allergic and autoimmune diseases. Here, using chromatin immunoprecipitation and real time reverse transcription PCR we identify the Polycomb family histone methyltransferase EZH2 as the enzyme responsible for methylating lysine 27 of histone H3 at the Il4-Il13 locus of T(H)1 but not T(H)2 cells, implicating EZH2 in the mechanism of Il4 and Il13 transcriptional silencing.
Distributed platoon assignment and lane selection for traffic flow optimization (2008)

This paper presents an approach to lane assignment for highway vehicles that increases traffic throughput while ensuring vehicles can exit successfully at their destinations. To enhance traffic safety and increase lane capacities, vehicles can be organized into platoons with the objective of maximizing the travel distance that platoons stay intact and then apply lane assignment to these platoons. The goal of this research is to form a distributed control strategy to select lanes for platoons using inter-vehicle communication. We evaluate the current platoon lane assignment strategy and compare its improvement over average vehicle travel time with the lane assignment for single vehicles reported in our previous work. Simulation results show that while cooperate control for single vehicle lane assignment does lead to decreased vehicle travel times, the implementation of cooperative lane assignment for platooning vehicles leads to an even greater reduction.
Saikosaponin a and Saikosaponin d Inhibit Proliferation and Migratory Activity of Rat HSC-T6 Cells (2013)

The proliferation and migration of hepatic stellate cells (HSCs) profoundly impact the pathogenesis of liver inflammation and fibrogenesis. As a perennial herb native to China, Bupleurum falcatum is administered for its anti-inflammatory, antipyretic, and antihepatotoxic effects. Saikosaponin a (SSa) and Saikosaponin d (SSd) are the major active components of triterpene saponins in Bupleurum falcatum. This study analyzes how SSa and SSd affect rat HSC-T6 cell line proliferation and migration. Experimental results indicate that, in addition to suppressing HSC-T6 proliferation, wound healing activity and cell migration in a time- and dose-dependent manner, SSa and SSd significantly induce apoptosis. Additionally, SSa and SSd decreased the expressions of extracellular matrix-regulated kinase 1/2 (ERK1/2), platelet-derived growth factor receptor 1 (PDGFR1), and subsequently transforming growth factor-β1 receptor (TGF-β1R), α-smooth muscle actin, TGF-β1 and connective tissue growth factor. They also decreased phosphorylation of p38 (p-p38) and ERK1/2 (p-ERK1/2) of HSC-T6. Furthermore, both SSa and SSd can block PDGF-BB and TGF-β1-induced cell proliferation and migration of HSC-T6. These results suggest that SSa and SSd may inhibit proliferation and activation of HSC-T6, and the modulated mechanisms warrant further study.
YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model (2015)

Ewing sarcoma is an aggressive tumor of bone and soft tissue affecting predominantly children and young adults. Tumor-specific chromosomal translocations create EWS-FLI1 and similar aberrant ETS fusion proteins that drive sarcoma development in patients. ETS family fusion proteins and over-expressed ETS proteins are also found in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) patients. Transgenic expression of EWS-FLI1 in mice promotes high penetrance erythroid leukemia with dense hepatic and splenic infiltrations. We identified a small molecule, YK-4-279, that directly binds to EWS-FLI1 and inhibits its oncogenic activity in Ewing sarcoma cell lines and xenograft mouse models. Herein, we tested in vivo therapeutic efficacy and potential side effects of YK-4-279 in the transgenic mouse model with EWS-FLI1 induced leukemia. A two-week course of treatment with YK-4-279 significantly reduced white blood cell count, nucleated erythroblasts in the peripheral blood, splenomegaly, and hepatomegaly of erythroleukemic mice. YK-4-279 inhibited EWS-FLI1 target gene expression in neoplastic cells. Treated animals showed significantly better overall survival compared to control mice that rapidly succumbed to leukemia. YK-4-279 treated mice did not show overt toxicity in liver, spleen, or bone marrow. In conclusion, this in vivo study highlights the efficacy of YK-4-279 to treat EWS-FLI1 expressing neoplasms and support its therapeutic potential for patients with Ewing sarcoma and other ETS-driven malignancies.
Further Observations on the Alcoholysis of Diethyl Diiminomalonate Monohydrochloride. Some New Pyrimidines (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFurther Observations on the Alcoholysis of Diethyl Diiminomalonate Monohydrochloride. Some New PyrimidinesS. M. McElvain and Bryce E. TateCite this: J. Am. Chem. Soc. 1951, 73, 6, 2760–2764Publication Date (Print):June 1, 1951Publication History Published online1 May 2002Published inissue 1 June 1951https://pubs.acs.org/doi/10.1021/ja01150a096https://doi.org/10.1021/ja01150a096research-articleACS PublicationsRequest reuse permissionsArticle Views365Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High Definition Television Studies on Compatible Basis with Present Standards (1981)

Present day television systems do not offer the optimum picture quality which is possible within the given standards. Compatible improvements are proposed which use digital preprocessing at the transmitter and signal postprocessing at the receiver. It is the author's opinion that, before any new standards for HDTV-Systems will be defined, the possible improvements within the given standards should be examined.
Parikshan: Live Debugging of Production Systems in Isolation (2015)

Modern 24x7 SOA applications rely on short deployment cycles, and fast bug resolution to maintain their services. Hence, time-to-bug localization is extremely important for any SOA application. We present live debugging, a mechanism which allows debugging of production systems (run test-cases, debug, or profile, etc.) on-the-fly. We leverage user-space virtualization technology (OpenVZ/LXC), to launch containers cloned and migrated from running instances of an application, thereby having two containers: production (which provides the real output), and debug (for debugging). The debug container provides a sandbox environment for debugging without any perturbation to the production environment. Customized network-proxy agents replicate or replay network inputs from clients to both the production and debug-container, as well as safely discard all network output from the debug-container. We used our system, called Parikshan, to do live debugging on several real-world bugs, and effectively reduced debugging complexity and time.
Effects of alterations in calcium homeostasis on apoptosis during neoplastic progression. (1997)

Our previous studies showed that early, stage I preneoplastic cells (sup+ I) are highly susceptible to apoptosis, whereas the later, stage II preneoplastic cells (sup- II) are relatively resistant. To examine possible mechanisms that might explain these differences in the regulation of apoptosis, Ca2+ homeostasis was analyzed and comparisons were made between these two Syrian hamster embryo cell lines. The Ca2+ indicator, fura-2, and fluorescent microscopy were used to measure intracellular free calcium concentrations, [Ca2+]i. The results indicated that the [Ca2+]i level in logarithmically growing sup+ I cells (approximately 100 nM) was considerably lower than that observed in sup- II cells (approximately 260 nM). Serum removal resulted in a reduction of [Ca2+]i in the sup+ I cells (approximately 82 nM), whereas the [Ca2+]i level in sup- II cells did not change. Endoplasmic reticulum (ER) calcium levels were determined by measuring thapsigargin-releasable Ca2+. Reduced ER calcium was consistently observed in cells induced to undergo apoptosis. Specifically, thapsigargin-releasable Ca2+ was greatly reduced in sup+ I cells (45 nM) as compared to sup- II cells (190 nNM) after 4 h in low serum. When sup- II cells were placed under conditions that resulted in apoptosis (thapsigargin or okadaic acid), decreased ER calcium was observed. To determine whether reduced ER calcium had a causative effect in apoptosis, ER calcium levels were exogenously increased in sup+ I cells by raising extracellular Ca2+ to 3 mM; ER calcium levels were maintained, and apoptosis was blocked. Studies were performed to determined whether the decrease in ER calcium could be attributed to reduced Ca2+ influx at the plasma membrane. To measure directly whether Ca2+ entry was decreased in sup+ I cells in 0.2% serum, Mn2+ uptake was used to monitor Ca2+ influx. The data show that in low serum, the rate of thapsigargin-induced Mn2+ entry in sup+ I cells was approximately 50% lower than that of sup- II cells, demonstrating that capacitative entry is reduced in sup+ I cells. In further support of this hypothesis, thapsigargin-treated sup+ I cells (0.2% serum) showed decreased Ca2+ entry upon raising extracellular Ca2+ from 0 to 2 mM. We report the novel finding that early preneoplastic cells, which exhibit a high propensity to undergo apoptosis, have decreased calcium entry at the plasma membrane, resulting in decreased ER calcium pools. This study provides new insight into mechanisms that can be involved in the regulation/dysregulation of apoptosis during neoplastic progression. Furthermore, the data imply that preneoplastic cells, which have developed a mechanism to maintain ER calcium, would be less susceptible to apoptosis and would thus have an increased potential for becoming transformed.
Control of pathogenic CD8<sup>+</sup> T cell migration to the brain by IFN‐γ during experimental cerebral malaria (2008)

Previous studies have shown that IFN-gamma is essential for the pathogenesis of cerebral malaria (CM) induced by Plasmodium berghei ANKA (PbA) in mice. However, the exact role of IFN-gamma in the pathway (s) leading to CM has not yet been described. Here, we used 129P2Sv/ev mice which develop CM between 7 and 14 days post-infection with PbA. In this strain, both CD4(+) and CD8(+) T cells were involved in the effector phase of CM. When 129P2Sv/ev mice deficient in the IFN-gamma receptor alpha chain (IFN-gammaR1) were infected with PbA, CM did not occur. Migration of leucocytes to the brain at the time of CM was observed in wild type (WT) but not in deficient mice. However, in the latter, there was an accumulation of T cells in the lungs. Analysis of chemokines and their receptors in WT and in deficient mice revealed a complex, organ-specific pattern of expression. Up-regulation of RANTES/CCL5, IP-10/CCL3 and CCR2 was associated with leucocyte migration to the brain and increased expression of MCP-1/CCL2, IP-10/CCL3 and CCR5 with leucocyte migration to the lung. This shows that IFN-gamma controls trafficking of pathogenic T cells in the brain, thus providing an explanation for the organ-specific pathology induced by PbA infection.
Effects of Hot Water Extracts of Several Kanpo-Prescriptions on Macrophage Procoagulant Activity. I (1984)

The effects of decoctions of four Kanpo-prescriptions (Keishi-Ni-Eppi-Ittoh-Ka-Ryoh-Jutsu-Bu, Keishi-Ka-Jutsu-Bu-Toh, Keishi-Shakuyaku-Tchimo-Toh, and Yokuinin-Toh), which are widely used in Japan for the therapy of rheumatoid arthritis, on macrophage procoagulant activity was investigated. Peritoneal exudate cell of guinea pig was used as a macrophage source. These four decoctions were added to the macrophage suspensions in vitro, and each suspension was incubated for 14 h at 37°C. Macrophage procoagulant activity was measured by the method similar to that of determination of the recalcification time of the plasma. It was found that the decoctions of these four Kanpoprescriptions potentiated remarkably the macrophage procoagulant activity. In addition, we examined similarly the effect on the macrophage procoagulant activity of 18 kinds of crude drug including the constituents of these four prescriptions, and the decoctions of three kinds of crude drug, Byakujutsu, Sohjutsu, and Maoh, had apparent enhancing effect on it. Since every four Kanpo-prescription described above includes Byakujutsu or Maoh, their potentiating activity on macrophage procoagulant activity was dependent on the active substances of Byakujutsu and Maoh.
The autism-mutated ADNP plays a key role in stress response (2019)

Activity-dependent neuroprotective protein (ADNP), discovered and first characterized in our laboratory (IG), is vital for mammalian brain formation and presents one of the leading genes mutated de novo causing an autistic syndrome, namely the ADNP syndrome. Furthermore, a unique mouse model of Adnp-haploinsufficiency was developed in the laboratory (IG), with mice exhibiting cognitive and social deficiencies. ADNP is regulated by vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase-activating peptide (PACAP). In this respect, PACAP was independently identified as a sexual divergent master regulator of the stress response. Here, we sought to determine the impact of the Adnp genotype and the efficacy of PACAP pre-treatment when subjecting Adnp<sup>+/-</sup> mice to stressful conditions. Significant sex differences were observed with Adnp<sup>+/-</sup> males being more susceptible to stress in the object and social recognition tests, and the females more susceptible in the open field and elevated plus maze tests. Splenic Adnp expression and plasma cortisol levels in mice were correlated with cognition (male mice) and anxiety-related behavior. These findings were further translated to humans, with observed correlations between ADNP expression and stress/cortisol content in a young men cohort. Altogether, our current results may establish ADNP as a marker of stress response.
Fully Integrated Digital Average Current-Mode Control Voltage Regulator Module IC (2017)

This paper introduces a fully integrated 12-to-1.xV voltage regulator module IC. A fully synthesizable digital two-loop controller has been realized through hardware description language tools. Several new IP blocks have been developed and described in detail: a window delay-line-based analog to digital converter (DL-ADC), two independent PI compensators with shared hardware for calculations, high-resolution digital pulsewidth modulation (PWM), and a programmable dead-time module. To fully exploit the benefits of digital electronics, reduce power consumption, and save area, all units of the digital controller have been designed through asynchronous architecture, eliminating the need of high-speed clock. High-performance synchronized, fixed frequency, PWM operation is enabled by a digital programmable time-base generator and system governor, which has been developed as well. In addition, to extend the capabilities of the window DL-ADC to support the full range of the load with minimal hardware penalty, adaptive reference of the current compensation is introduced. The mixed-signal IC has been fabricated on a 0.18-μm 5-V CMOS process. It incorporates the digital controller and periphery as well as a synchronous buck power stage, including a drive circuitry that enables operation up to several megahertz from a 12-V input. The digital core has been realized by an automated synthesis process and place-and-route tools, resulting in an effective silicon area of 0.16 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Experimental results of the fabricated IC operating in closed loop are provided, demonstrating the performance and benefits of the new controller for meeting the requirements of tight output voltage regulation over wide load range.
Cu‐Decorated ZnO Nanorod Array Integrated Structured Catalysts for Low‐Pressure CO<sub>2</sub> Hydrogenation to Methanol (2017)

Abstract CO 2 conversion into valuable chemicals and fuels, such as methanol, is one of the most practical routes for utilizing emitted CO 2 and mitigating global warming. Herein, a 3D Cu‐decorated ZnO nanorod array based structured catalysts for efficient thermochemical CO 2 hydrogenation to methanol at relatively low pressures (<10 atm) is successfully fabricated and demonstrated. This new type of nanorod array integrated structured catalysts has yielded a methanol formation rate of 1.9 mol h −1 kg −1 with a methanol selectivity of 56%, rivaling the state‐of‐the‐art powder‐form catalysts. The well‐dispersed copper species on the array structure as well as the array‐structure‐enhanced interfacial effect are key factors that improve the activity of the nanorod array catalysts in CO 2 hydrogenation. The Cu‐ZnO nanorod array interface also suppresses reverse water‐gas shift reaction, reducing the selectivity to CO. Further improvement of the performance of the nanorod array based catalysts is demonstrated by tuning the ZnO nanorod array length. The developed nanorod array integrated monolithic catalysts also exhibit good stability during a long‐time continuous operation, demonstrating the potential and the feasibility of their practical implementation in industrial situation.