gebhart/patrepeval huggingface dataset:
Normal values of pulmonary capillary wedge pressure and the blood pressure response to the Valsalva manoeuvre in healthy elderly subjects (2005)

The blood pressure response to the Valsalva manoeuvre is related to pulmonary capillary wedge pressure (PCWP) and can be used to diagnose heart failure. However, this has never been studied specifically in the elderly, in whom the prevalence of heart failure is highest. Furthermore, normal values of the Valsalva manoeuvre are lacking. We aimed to obtain normal values of PCWP and the blood pressure response to the Valsalva manoeuvre in elderly subjects. Therefore, 28 healthy subjects, aged 70 +/- 4 years, performed Valsalva manoeuvres before and after anti-G garment inflation, which was used for temporary increase of PCWP. Before inflation, PCWP was 9.8 +/- 1.9 mmHg in supine and 8.9 +/- 2.1 in semi-recumbent position. From the blood pressure response, measured with Finapres, the systolic blood pressure ratio (SBPR), pulse pressure ratio (PPR), stroke volume ratio (SVR) and heart rate ratio (HRR) were calculated. In supine position, SBPR was 0.76 +/- 0.11, PPR 0.51 +/- 0.16, SVR 0.42 +/- 0.11, and HRR 1.17 +/- 0.12. Semi-recumbently, SBPR was 0.74 +/- 0.10, PPR 0.46 +/- 0.14, SVR 0.41 +/- 0.10, and HRR 1.24 +/- 0.23. After inflation of the anti-G garment, the areas under the Receiver Operator Characteristics curves of SBPR, PPR and SVR for elevated (> or = 15 mmHg) PCWP were >0.85 in supine position. In conclusion, this is the first study to obtain normal values of the blood pressure response to the Valsalva manoeuvre and PCWP in healthy elderly subjects, which is essential for the interpretation of patient data. The Valsalva manoeuvre showed significant discriminatory power in the detection of elevated PCWP, which underscores its potential in the non-invasive diagnosis of heart failure.
Approximate Entropy from Overnight Pulse Oximetry for the Obstructive Sleep Apnea Syndrome (2005)

The aim of this preliminary study was to asses whether a time series analysis from overnight pulse oximetry by means of Approximate Entropy (ApEn) could yield essential information on the diagnosis of obstructive sleep apnea (OSA) syndrome. We analyzed the oxygen saturation (SaO2) signals of 74 patients (44 with a positive diagnosis of OSA and 30 with a negative diagnosis of OSA) by means of ApEn, which quantified the regularity (or complexity) of time series. Results showed that recurrence of apnea events in patients with OSA determined a significant increase in ApEn values with a mean .. standard deviation (SD) of 1.07 +/- 0.30. A mean +/-SD ApEn value of 0.47 +/- 0.25 was estimated in patients without OSA. We obtained an area under the ROC curve of 0.94. The optimum threshold was selected at 0.81, where we achieved a 79,5% sensitivity and 90% specificity. Further analyses are necessary with new and larger data set to test the potential value of our methodology prospectively.
The Effect of Initial Head Position on Active Cervical Axial Rotation Range of Motion in Two Age Populations (1996)

The results suggest that varying the starting sagittal head position may affect the anatomic structures involved in restraining axial rotation. This supports the clinical approach to range of motion assessment in combined movement patterns.
Disorders of Thrombosis and Hemostasis: Clinical and Laboratory Practice (1992)

Physiology of Hemostasis Rodger L. Bick and Genesio MuranoPatients with Hemorrhage Rodger L. BickHereditary and Acquired Vascular Thrombohemorrhagic Disorders Rodger L. BickPlatelet Function Defects Rodger L. BickThrombocytopenia and Thrombocytosis Eugene P. FrenkelHereditary Coagulation Protein Defects Frank Nizzi, Suneeti Sapatnekar and Rodger L. BickDisseminated Intravascular Coagulation Rodger L. BickThrombohemorrhagic Defects in Liver and Renal Diseases Eberhard F. MammenThrombotic and Hemorrhagic Problems During Cardiovascular Bypass Surgery and Cardiovascular Procedures Rodger L. BickAcquired Blood Coagulation Inhibitors Yale S. Arkel and De-Hui W. KuClinical Approach to the Patient with Thrombosis, Thromboembolus, and Pulmonary Embolus Rodger L. Bick and William F. BakerThrombohemorrhagic Defects Associated with Malignancy Eugene P. Frenkel and Rodger L. BickHereditary Thrombophilic Disorders Rodger L. Bick and William F. Baker, Jr.Acquired Thrombophilia Rodger L. Bick and William F. BakerThromboprophylaxis and Thrombosis in Medical, Surgical, Trauma and Obstetrical/Gynecological Patients Rodger L. Bick and Sylvia HaasOral Antithrombotic Therapy: Warfarins and Related Compounds Graham Pineo and Russell D. HullHeparin and Low-Molecular-Weight Heparins Rodger L. BickAntiplatelet Therapy Hans Klaus BreddinThrombolytic Therapy William F. Baker, Jr.Hemostatic Factors in Atherothrombotic Disease Yale S. Arkel and De-Hui W. Ku Inde
<title>Comparison of hot-pressing, rate-controlled sintering, and microwave sintering of magnesium aluminate for optical applications</title> (1999)

There are several crystalline materials that transmit electromagnetic radiation in the visible and IR portion of the spectrum. At this time, single-crystal sapphire, aluminum oxynitride (ALON), and spinel show promise for applications, including advanced electromagnetic windows and transparent armor. These applications require materials with high strength, hardness, and the ability to withstand high temperatures. Because of lower processing temperatures and shorter processing times, it is reasonable to assume that spinel should ultimately be less costly to produce than ALON or sapphire. Despite many attempts to commercialize spinel, it is not available today as an optical materials due to difficulties in reliably obtaining the desired transparently. To help develop a commercial source for transparent spinel, the US Army Research Laboratory and Ceramic Composites Inc. of Annapolis have signed a Cooperative Research and Development Agreement on the 'Development and Dual-Use Assessment of Transparent Spinel'. The advent of commercially available, highly pure spinel powders should lead to improvements in processing spinel to transparency. This investigation compares the advantages and limitations of hot-pressing, microwave sintering, and rate- controlled sintering and compares the limited property data available from each of these fabrication techniques.
Performance analysis of an integrated eye gaze tracking / electromyogram cursor control system (2007)

Eye Gaze Tracking (EGT) systems allow individuals with motor disabilities to quickly move a screen cursor on a PC. However, there are limitations in the steadiness and the accuracy of cursor control and clicking capabilities they provide. On the other hand, a cursor control system to step the cursor up, down, left or right in response to voluntary contractions of specific facial muscles, developed by our group, provides steady and precise, albeit slow, cursor control, along with a reliable clicking mechanism. This system identifies muscle contractions by performing digital processing of the Electromyogram (EMG) signals generated by the facial muscles. Based on the complementary nature of the strengths of these two cursor control modalities we have developed an integrated EGT/EMG system in an attempt to consolidate the advantages of both input modalities. We have compared the selection accuracy and speed of an EGT-only cursor control implementation, our integrated EGT/EMG cursor control system and a standard handheld mouse in point-and click trials.
A Probabilistic Particle-Control Approximation of Chance-Constrained Stochastic Predictive Control (2010)

Robotic systems need to be able to plan control actions that are robust to the inherent uncertainty in the real world. This uncertainty arises due to uncertain state estimation, disturbances, and modeling errors, as well as stochastic mode transitions such as component failures. Chance-constrained control takes into account uncertainty to ensure that the probability of failure, due to collision with obstacles, for example, is below a given threshold. In this paper, we present a novel method for chance-constrained predictive stochastic control of dynamic systems. The method approximates the distribution of the system state using a finite number of particles. By expressing these particles in terms of the control variables, we are able to approximate the original stochastic control problem as a deterministic one; furthermore, the approximation becomes exact as the number of particles tends to infinity. This method applies to arbitrary noise distributions, and for systems with linear or jump Markov linear dynamics, we show that the approximate problem can be solved using efficient mixed-integer linear-programming techniques. We also introduce an important weighting extension that enables the method to deal with low-probability mode transitions such as failures. We demonstrate in simulation that the new method is able to control an aircraft in turbulence and can control a ground vehicle while being robust to brake failures.
Reduction of Left Ventricular Hypertrophy After Exercise and Weight Loss in Overweight Patients With Mild Hypertension (2002)

In a cohort of overweight, sedentary men and women, exercise and weight loss reduced blood pressure and induced favorable changes in left ventricular structure.
Robustness of RF MEMS Capacitive Switches With Molybdenum Membranes (2009)

This paper compares the characteristics of an RF microelectromechanical systems (MEMS) capacitive switch with a molybdenum membrane versus that of a switch with similar construction but with an aluminum membrane. In comparison, the molybdenum switch exhibits a significantly reduced sensitivity to ambient temperature change so that its pull-in voltage varies by less than 0.035 V/°C. In addition, large-signal RF performance of the switches was compared under both continuous wave and pulse conditions. The results show that under large RF signals, the self-biasing effect is exacerbated by the self-heating effect and the self-heating effect is in turn amplified by nonuniform current and temperature distributions on the membrane. Measurements of both molybdenum and aluminum switches demonstrate a hot-switched power-handling capacity of approximately 600 mW. Since aluminum has been used as a membrane material for over a decade while molybdenum is new, the above results indicate that molybdenum is a promising membrane material for RF MEMS capacitive switches.
C<sub>61</sub>Br<sub>2</sub>: a new synthesis of dibromomethanofullerene and mass spectrometric evidence of the carbon allotropes C<sub>121</sub>and C<sub>122</sub> (1996)

The new preparative synthesis and the characterization of 1′,1′-dibromo-1,2-methano[60]fullerene 1a using a Seyferth reagent and the mass spectrometric evidence of the novel dumb-bell shaped molecular carbon allotropes C121 2 and C122 3 obtained via a proposed intermediate C60C: carbene generated from 1a are reported.
A high performance video server for karaoke systems (1994)

A high performance and low cost video server architecture is proposed for karaoke systems which can store more than 200 Gbytes of video and support up to 30 concurrent users simultaneously. Moreover, a novel caching strategy, called head caching, is proposed which can significantly reduce the initial delay. With this strategy, the initial delay can be dramatically reduced without increasing the cache size. Besides, using head caching scheme, the proposed system can act as a general video server which can support fast-forward, rewind, and dynamic panning controls.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Trilaciclib prior to chemotherapy and atezolizumab in patients with newly diagnosed extensive‐stage small cell lung cancer: A multicentre, randomised, double‐blind, placebo‐controlled Phase <scp>II</scp> trial (2020)

Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were evaluated in a randomised, double-blind, placebo-controlled Phase II study in patients with newly diagnosed extensive-stage small cell lung cancer (ES-SCLC) (NCT03041311). The primary endpoints were duration of severe neutropenia (SN; defined as absolute neutrophil count <0.5 × 10<sup>9</sup> cells per L) in Cycle 1 and occurrence of SN during the treatment period. Other endpoints were prespecified to assess the effects of trilaciclib on additional measures of myelopreservation, patient-reported outcomes, antitumour efficacy and safety. Fifty-two patients received trilaciclib prior to E/P/A and 53 patients received placebo. Compared to placebo, administration of trilaciclib resulted in statistically significant decreases in the mean duration of SN in Cycle 1 (0 vs 4 days; P < .0001) and occurrence of SN (1.9% vs 49.1%; P < .0001), with additional improvements in red blood cell and platelet measures and health-related quality of life (HRQoL). Trilaciclib was well tolerated, with fewer grade ≥3 adverse events compared with placebo, primarily due to less high-grade haematological toxicity. Antitumour efficacy outcomes were comparable. Administration of trilaciclib vs placebo generated more newly expanded peripheral T-cell clones (P = .019), with significantly greater expansion among patients with an antitumour response to E/P/A (P = .002). Compared with placebo, trilaciclib administered prior to E/P/A improved patients' experience of receiving treatment for ES-SCLC, as shown by reduced myelosuppression, and improved HRQoL and safety profiles.
A probabilistic learning approach to motion planning (1995)

In this paper a new paradigm for robot motion planning is proposed. We split the motion planning process into two phases: the learning phase and the query phase. In the learning phase we construct a probabilistic roadmap in configuration space. This roadmap is a graph where nodes correspond to randomly chosen configurations in free space and edges correspond to simple collision-free motions between the nodes. These simple motions are computed using a fast local method. The longer we learn, the denser the roadmap becomes and the better it is for motion planning. In the query phase we can use this roadmap to find paths between different pairs of configurations. If a possible path is not found one can always extend the roadmap by learning further. This gives a very flexible scheme in which learning time and success for queries can be balanced. We will demonstrate the power of the paradigm by applying it to various instances of motion planning : free flying planar robots, plan...
Squamous Cell Carcinoma of the Nail Bed: Three Case Reports (2004)

Squamous cell carcinoma of the nail bed is rare, and the disease is often misdiagnosed as a benign condition. Digital amputation is often performed because of the delay in diagnosis and the involvement of the distal phalanx. Between March 1999 and March 2002, 3 patients presented to the Pamela Youde Nethersole Eastern Hospital, Hong Kong, with squamous cell carcinoma of the nail bed. Two of the patients underwent a digit-salvaging procedure-namely, wide local excision and flap coverage-and their functional outcome was satisfactory. The remaining patient received partial amputation of the thumb without significant functional loss. A high degree of suspicion is thus needed to detect squamous cell carcinoma of the nail bed; a biopsy of chronic recurrent nail bed lesions should be performed.
Reaction of triflic anhydride with Grignard reagents. Oxidizing properties of triflic anhydride (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of triflic anhydride with Grignard reagents. Oxidizing properties of triflic anhydrideXavier CrearyCite this: J. Org. Chem. 1980, 45, 13, 2727–2729Publication Date (Print):June 1, 1980Publication History Published online1 May 2002Published inissue 1 June 1980https://pubs.acs.org/doi/10.1021/jo01301a042https://doi.org/10.1021/jo01301a042research-articleACS PublicationsRequest reuse permissionsArticle Views1015Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Concurrent Transmission MAC Protocol for Enhancing Throughout and Avoiding Spectrum Sensing in Cognitive Radio (2007)

For the cognitive radio (CR) network, a fundamental issue is how to identify the spectrum opportunities. First, each CR node determines whether there exists transmission opportunities on unlicensed bands. If not, this node will find other opportunity on licensed bands. Thus, increasing the opportunities of concurrent transmissions in unlicensed bands can reduce the overhead of wide-band sensing. In this paper, based on the carrier sensing multiple access protocol, the paper proposed a novel concurrent transmissions MAC (CT-MAC) protocol to identify the possibility of establishing the second link in the presence of the first link in the unlicensed band. In addition to reducing the overhead of wide-band sensing, the proposed CT-MAC scheme can enhance overall throughput and is backward compatible with the IEEE 802.11 standard.
Smart Polymer Based Delivery Systems for Peptides and Proteins (2007)

Biodegradable polymeric systems represent promising means for delivering many bioactive agents, including peptide and protein drugs. The importance of these systems grew with the advancement in the understanding of peptide and protein pharmacology as well as the ability to mass-produce these compounds. Some polymers undergo sol-gel transition once administered. In situ gel formation happens in response to one or a combination of two or more stimuli. These stimuli include UV-irradiation, pH change, temperature change, and solvent exchange. These smart polymeric systems have several advantages over conventional methods, such as ease of manufacturing, ease of administration, biodegradability, and the ability to alter release profiles of the incorporated agents. In the past few years, an increasing number of in situ gel-forming systems have been investigated and many patents for their use in various biomedical applications, including drug delivery, have been reported. In this article, we introduce the different strategies that have been developed and patented for the use of smart polymers in delivering peptide and protein drugs. The advantage, disadvantages, possibilities, and limitations of each of the smart polymer systems have been discussed.
The Microcirculation Is Unchanged in Neonates with Severe Respiratory Failure after the Initiation of ECMO Treatment (2012)

Purpose. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is known to improve cardiorespiratory function and outcome in neonates with severe respiratory failure. We tested the hypothesis that VA-ECMO therapy improves the microcirculation in neonates with severe respiratory failure. Methods. This single-center prospective observational pilot study took place in an intensive care unit of a level III university children's hospital. Twenty-one-term neonates, who received VA-ECMO treatment, were included. The microcirculation was assessed in the buccal mucosa, using Orthogonal Polarization Spectral imaging, within 24 hours before (T1) and within the first 24 hours after initiation of ECMO treatment (T2). Data were compared to data of a ventilated control group (N = 7). Results. At baseline (T1), median functional capillary density (FCD), microvascular flow index (MFI), and heterogeneity index (HI) did not differ between the ECMO group and the control group. At T2 the median FCD was lower in the control group (median [range]: 2.4 [1.4-4.2] versus 4.3 [2.8-7.4] cm/cm(2); P value <0.001). For MFI and HI there were no differences at T2 between the two groups. Conclusion. The perfusion of the microcirculation does not change after initiation of VA-ECMO treatment in neonates with severe respiratory failure.
Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA (2008)

Short continuous regions of VAR2CSA with affinity for multiple types of CSA were defined. A number of these regions localize to CSA-binding domains and to surface-exposed regions within these domains and a synthetic peptide corresponding to a peptide sequence in DBL2 was shown to bind to CSA and not to CSC. It is likely that some of these epitopes are involved in native parasite CSA adhesion. However, antibodies directed against single epitopes did not inhibit parasite adhesion. This study supports phage display as a technique to identify CSA-binding regions of large proteins such as VAR2CSA.
Sampling (1969)

Sampling requirements for prospective landed extraterrestrial geological and biological instruments performing on-site analyses are satisfied by three general classes of samplers: bulk, selective particulate, and hard rock. Bulk samplers are noted as the type preferred by some, both for geological and biological experiments, but are more complex and require more processing steps than the simpler selective particulate samplers which reject oversize particulate material at the acquisition step. The steps required in sample acquisition and processing, and various methods of implementing them, are explained. Criteria for sampler selection are noted.
A new approach to imaging with low-frequency electromagnetic fields (1993)

Abstract We present a new method for interpreting electromagnetic (EM) data using ray tomography. Direct application of ray tomography to low-frequency EM data is difficult because of the diffusive nature of the field. Diffusive EM fields can, however, be mathematically transformed to wavefields defined in a time-like variable. The transform uniquely relates a field satisfying a diffusion equation in time, or in frequency, to an integral of the corresponding wavefield. If the corresponding wavefields can be computed from low-frequency EM data, one should be able to interpret these data using techniques developed for the wavefields.To test the idea, numerically calculated transient magnetic fields were first transformed to wavefields. The typical window of the time-domain data required for the transform is 1.5 decades. Traveltimes from a source to the receivers were estimated from the reconstructed wavefields. Time-domain data with a Gaussian noise of 3 percent gave a traveltime resolution of better than one percent.For the tomographic inversion, the cross-section between the transmitter and receiver boreholes is divided into a number of rectangular elements, and a continuous slowness is assigned to each of these elements. A functional is formulated by invoking Fermat's principle for the traveltime data. Imposing a stationary condition on the functional gives an iterative procedure for the slowness model. Rays are allowed to bend smoothly within each cell. Incorporating smoothly bending rays is extremely important when the velocity contrast is large. A model with a conductivity contrast of ten (10) has been successfully imaged in 120 iterations with 5 CPU hours on a SUN SPARCstation 2.