gebhart/patrepeval huggingface dataset:
Native Data Representation: an Efficient Wire Format for High Performance Computing (2001)

Flexible and high-performance data exchange is becoming increasingly important. This trend is due in part to the growing interest among highperformance researchers in tool- and component-based approaches to software development. In trying to reap the well-known benets of these approaches, the question of what communications infrastructure should be used to link the various application components arises. Traditional HPC-style communication libraries such as MPI oer good performance, but are not intended for loosely-coupled systems. Object- and metadatabased approaches like XML oer the needed plug-and-play exibility, but with signicantly lower performance. We observe that the exibility and baseline performance of data exchange systems are strongly determined by their `wire formats&apos;, or by how they represent data for transmission in the heterogeneous environments. Upon examining the performance implications of using a number of dierent wire formats, we propose an alternative approach to exible high-performance data exchange, Native Data Representation, and evaluate its current implementation in the Portable Binary I/O library. 1
Phosphoenolpyruvate Carboxylase of Escherichia coli. Specificity of Some Compounds as Activators at the Site for Fructose 1,6-Bisphosphate, One of the Allosteric Effectors12 (1984)

An investigation was performed to elucidate some unusual phenomena which had been observed with phosphoenolpyruvate (PEP) carboxylase [EC 4.1.1.31] of Escherichia coli. (i) Fructose 1,6-bisphosphate (Fru-1,6-P2) and GTP--the allosteric activators--were competitive with each other in the activation. (ii) Some analogs of PEP such as DL-2-phospholactate and 2-phosphoglycolate, which behaved as inhibitors in the presence of the activator (acetyl-CoA or dioxane), activated the enzyme to some extent in the absence of the activator. (iii) Ammonium sulfate deprived the enzyme of sensitivity to Fru-1,6-P2 or GTP but had no effect on the sensitivity to other effectors. It was found that the activation by the analogs was lost upon desensitization of the enzyme to Fru-1,6-P2 by reaction with 2,4,6-trinitrobenzene sulfonate. The activation by the analogs was not observed in the presence of 200 mM ammonium sulfate. In the presence of lower concentrations (0.1 mM) of PEP, ammonium sulfate activated the enzyme at concentrations less than 700 mM but had an inhibitory effect on the desensitized enzyme. These findings suggest that the unusual phenomena described above are a result of binding of the phosphate esters and sulfate ions with the Fru-1,6-P2 site of the enzyme or the active site depending on the reaction conditions.
Review of thermo-physical properties, wetting and heat transfer characteristics of nanofluids and their applicability in industrial quench heat treatment (2011)

The success of quenching process during industrial heat treatment mainly depends on the heat transfer characteristics of the quenching medium. In the case of quenching, the scope for redesigning the system or operational parameters for enhancing the heat transfer is very much limited and the emphasis should be on designing quench media with enhanced heat transfer characteristics. Recent studies on nanofluids have shown that these fluids offer improved wetting and heat transfer characteristics. Further water-based nanofluids are environment friendly as compared to mineral oil quench media. These potential advantages have led to the development of nanofluid-based quench media for heat treatment practices. In this article, thermo-physical properties, wetting and boiling heat transfer characteristics of nanofluids are reviewed and discussed. The unique thermal and heat transfer characteristics of nanofluids would be extremely useful for exploiting them as quench media for industrial heat treatment.
Hyaluronic acid stimulates neutrophil function in vitro and in vivo. A review of experimental results and a presentation of a preliminary clinical trial. (1980)

Hyaluronic acid (HA) stimulates normal neutrophil function both in vitro and in vivo Stimulation was also achieved by subcutaneous administration of HA to patients with extreme susceptibility to bacterial infections. Clinical improvement of some patients was obtained in connection to the administration. It is premature at this time to conclude any therapeutic effect of HA in patients with extreme infection propensity. The data presented here, however, for certain merit further investigation on this matter.
Structural Insights into Carbonic Anhydrase IX Isoform Specificity of Carbohydrate-Based Sulfamates (2014)

Carbonic anhydrase IX (CA IX) is an extracellular transmembrane homodimeric zinc metalloenzyme that has been validated as a prognostic marker and therapeutic target for several types of aggressive cancers. CA IX shares a close homology with other CA isoforms, making the design of CA IX isoform selective inhibitors challenging. In this paper, we describe the development of a new class of CA IX inhibitors that comprise a sulfamate as the zinc binding group, a variable linker, and a carbohydrate "tail" moiety. Seven compounds inhibited CA IX with low nM Ki values of 1-2 nM and also exhibited permeability profiles to preferentially target the binding of extracellular CA IX over cytosolic CAs. The crystal structures of two of these compounds in complex with a CA IX-mimic (a variant of CA II, with active site residues that mimic CA IX) and one compound in complex with CA II have been determined to 1.7 Å resolution or better and demonstrate a selective mechanism of binding between the hydrophilic and hydrophobic pockets of CA IX versus CA II. These compounds present promising candidates for anti-CA IX drugs and the treatment for several aggressive cancer types.
A New Extremely Wideband Lumped Six-Port Reflectometer (1990)

The six-port reflectometer structure has been invented which may consist solely of lumped elements, is inherently dissipative but extremely broadband, covering bandwidths up to 3 decades of frequency. The contribution outlines the principle of operation of the device and presents some experiments with a GaAs monolithically integrated implementation operating in the frequency range 80 MHz - 7 GHz.
Cytokine Therapies in Crohns Disease: Where are We Now and where should We Go? (2011)

In the gut of patients with Crohn's disease (CD), one of the major forms of inflammatory bowel diseases in humans, distinct subsets of T helper (Th) cells produce large amounts of cytokines, which are supposed to orchestrate the immuno-inflammatory process leading to the tissue damage. Indeed, cytokine blockers, including the three licensed anti-TNF-alpha and the neutralizing IL-12/p40 antibodies, have already been tested with success in CD. More than one third of patients do not respond to these treatments and response can wane with time. Moreover, blockade of such cytokines has been reported to associate with development of severe side effects and/or new immune-mediated pathologies. These findings and our better understanding of cytokine-associated effector pathways of tissue destruction suggest the necessity of novel cytokine-based therapies in CD.
Extravasation into synovial tissue induces CCL20 mRNA expression in polymorphonuclear neutrophils of patients with rheumatoid arthritis. (2005)

Recruitment of PMN to the synovial microenvironment induces expression of CCL20 mRNA independent of the concentrations of TNF-alpha accumulating in SF of patients with RA.
Muscle-actuated biomimetic hydrogel-based 3D microskeleton (2017)

This paper reports on a biomimetic microskeleton actuated by muscle fibers (figure 1(a)). The 3D microskeleton is based on concatenated rib elements fabricated by two-photon polymerization of a custom-made hydrogel (figure 1(b)). For the first time, micrometer-sized skeletons were fabricated, overgrown with functional muscle fibers, and contracted at significant amplitudes. Compared to planar biomimetic structures, 3D microskeletons can be shaped into arbitrary complex geometries, thereby opening pathways towards muscle-driven biohybrid microrobots.
Bioactivation of Selective Estrogen Receptor Modulators (SERMs) (2006)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTBioactivation of Selective Estrogen Receptor Modulators (SERMs)Tamara S. Dowers, Zhi-Hui Qin, Gregory R. J. Thatcher, and Judy L. BoltonView Author Information Department of Medicinal Chemistry and Pharmacognosy (M/C 781), College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612-7231 Cite this: Chem. Res. Toxicol. 2006, 19, 9, 1125–1137Publication Date (Web):August 15, 2006Publication History Received9 June 2006Published online15 August 2006Published inissue 1 September 2006https://pubs.acs.org/doi/10.1021/tx060126vhttps://doi.org/10.1021/tx060126vreview-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views781Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anatomy,Bioactivation,Cancer,Metabolism,Quinones Get e-Alerts
The Novel Synthesis of <scp>l</scp>-Hydroxyproline from <scp>d</scp>-Glutamic Acid (1974)

Abstract l-Hydroxyproline (1) and d-allo-hydroxyproline (2) were synthesized from d-glutamic acid (3) using the asymmetric center of 3 as that at C4 of 4-hydroxyproline. When the aqueous solution of 1 or 2 was heated at 200 °C for 2 hr, a solution in the equilibrium state, containing 55% of 1 and 45% of 2, was obtained. From this mixture, 1 was obtained by fractional crystallization.
HP Certified: HP-UX System Administration (2000)

The all-in-one authorized reference for HP certified, HP-UX system administration certification!If you are preparing for HP Certified, HP-UX System Administration certification, here's your all-in-one, authorized reference and preparation guide! The only preparation book approved by HP Education, HP Certified, HP-UX System Administration covers every exam objective in HP's three-part HP-UX System Administration exam (3HO-002). Best of all, this comprehensive book won't just help you prepare for the exam: it'll help you manage your systems for maximum efficiency today, tomorrow, and for years to come! Coverage includes all this, and more: UNIX and HP-UX fundamentals: installation, startup, logins, shells, processes, file systems, and more Managing users, groups, and accounts Security, auditing, performance management, and optimization HP-UX networking: configuring LAN devices, IP addresses, NFS, DNS, NIS, and more Printing, backup, storage management, kernel patches, peripherals, and more Essential shell programming and job automation techniques HP Certified: HP-UX System Administration contains detailed lists of exam objectives, summaries of key points and challenging review questions after every chapter, plus a complete sample exam. If you run HP-UX, this book is all you need to get certified. Even better, it's all you need to get results.
Regulation of vitamin D and calcium metabolism after gastrectomy. (1985)

Fifteen men, who had undergone Billroth I gastrectomy and 19 men who had undergone Billroth II gastrectomy were studied with respect to vitamin D and other indices of calcium metabolism. The Billroth I group had hypocalcaemia, raised concentration of serum alkaline phosphatase, and reduced bone mineral content. The same biochemical disturbances were found in the Billroth II group, but bone mineral content was normal. In neither of the groups was found signs of increased bone resorption. The calcium absorption was situated in the lower part of the normal range and the fractional absorption and elimination rates were normal. The 25OHD concentrations in both groups were reduced (p less than 0.05-0.01) and the 1.25(OH)2D concentrations raised (p less than 0.01-0.001). The 1,25(OH)2D concentrations were inversely related to bone mineral content, but directly related to signs of bone turnover and calcium absorption. We suggest that the high 1,25(OH)2D concentration is the result of a compensatory process with the aim of preventing hypocalcaemia.
Enhancement of Enzyme Activity in Supercritical Carbon Dioxide via Changes in Acid‐Base Conditions (2002)

Enzyme performance is often impaired in supercritical carbon dioxide. We were able to enhance enzyme activity in this medium via changes in acid-base conditions by using ion-exchange materials (solid H(+)/Na(+) buffer pairs and a zeolite), which were selected on the basis of the response of an organosoluble acid-base indicator. The concentration of ion-exchange materials had an important effect on the catalytic activity of subtilisin Carlsberg cross-linked enzyme crystals (CLECs), and this was related to the protonation and hydration states of the enzyme. The buffer Na(2)CO(3)/NaHCO(3) gave the highest enhancement in enzyme activity (by a factor of 54), probably as a result of its high basicity and capacity to counteract the deleterious effect of carbonic acid to a greater extent than the other materials tested.
A COMPARISON OF THE EFECTS OF TOPICAL CYCLOSPORINE AND TOPICAL STEROID ON RABBIT CORNEAL ALLOGRAFT REJECTION (1985)

A comparison was made of the effects of topically applied cyclosporine, and topically applied prednisolone acetate, on the prolongation of corneal allograft survival in a recently developed prevascularized rabbit eye model. Animals were treated four times daily for 28 days postgrafting. Both drugs prolonged graft survival when compared with placebo or no treatment but the corticosteroid was significantly more effective than cyclosporine. Furthermore, anterior segment inflammation and graft vascularization were considerably less marked in animals treated with steroid. No cyclosporine could be detected by radioimmunoassay in anterior chamber fluid removed by paracentesis from grafted animals treated with cyclosporine, suggesting poor absorption of the drug across the cornea.
Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei. (1990)

Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to the 24-hr day/night cycle by periodic environmental light cues. We show that light alters the immunoreactive levels of a transcriptional regulatory protein, Fos, in the suprachiasmatic nuclei of albino rats. Photic regulation of Fos immunoreactivity does not occur in other retino-recipient brain areas except for the intergeniculate leaflet, which appears to be involved in mediating some of the complex effects of light on expressed circadian rhythms. Our results point to a promising new functional marker for the cellular effects of light and suggest that the expression of Fos or a related nuclear protein may be part of the mechanism for photic entrainment of the circadian clock to environmental light/dark cycles.
Honey and Its Uses in the Home (1915)

Report discussing the home production, use, and nutritional value of honey. Includes recipes.
Dual-ALU Structure Processor for Speech Recognition (2006)

This paper proposed a low-cost dual-ALU processor for speech recognition. It does not give an emphasis on sophistication but on low-cost solution. The dual-ALU architecture provides parallel calculation capability. For the consideration of chip size, the area of the second ALU is only half of the first ALU. We use hardware-software codesign method to implement the speech recognition. The feature extraction bases on LPC-cepstrum coefficients, and template matching employs hidden Markov models (HMM). The processor is designed to process the HMM and connect with the ASIC of LPC-cepstrum.
Geiger-mode operation of ultraviolet avalanche photodiodes grown on sapphire and free-standing GaN substrates (2010)

GaN avalanche photodiodes (APDs) were grown on both conventional sapphire and low dislocation density free-standing (FS) c-plane GaN substrates. Leakage current, gain, and single photon detection efficiency (SPDE) of these APDs were compared. At a reverse-bias of 70 V, APDs grown on sapphire substrates exhibited a dark current density of 2.7×10−4 A/cm2 whereas APDs grown on FS-GaN substrates had a significantly lower dark current density of 2.1×10−6 A/cm2. Under linear-mode operation, APDs grown on FS-GaN achieved avalanche gain as high as 14 000. Geiger-mode operation conditions were studied for enhanced SPDE. Under front-illumination the 625-μm2-area APD yielded a SPDE of ∼13% when grown on sapphire substrates compared to more than 24% when grown on FS-GaN. The SPDE of the same APD on sapphire substrate increased to ∼30% under back-illumination—the FS-GaN APDs were only tested under front illumination due to the thick absorbing GaN substrate.
Electromechanically driven and sensed parametric resonance in silicon microcantilevers (2006)

We report on the design and experimental measurements of an integrated driving and sensing technique in parametrically excited silicon microcantilevers. The design involves actuation with axial Lorentz forces and sensing with magnetomotive forces, both of which are enabled by a chip-scale permanent magnet. In this demonstration the micromechanical parametric resonance is measured electrically. This system has applications to resonant parametric sensing.
Application of RF Discharges to Sputtering (1970)

The operation of rf discharges is described and the internal distribution of voltages is considered. The significance of this with respect to sputtering, particularly of insulators, is then discussed. An equivalent circuit for the discharge is presented and the influence of such parameters as pressure and magnetic field on the components of this circuit is described. Finally, energy distributions for positive ions, electrons, and negative ions incident at the substrate during deposition are given.
Cloning and sequence analysis of cDNA for corticotropin-releasing factor precursor from the teleost fish Catostomus commersoni. (1988)

The sequence of a cDNA encoding the corticotropin-releasing factor precursor has been identified by screening lambda gt11 libraries constructed from poly(A)+ RNA of the hypothalamic region of the white sucker Catostomus commersoni brain with synthetic oligonucleotide probes deduced from the sequence of the rat corticotropin-releasing factor. The amino acid sequence of corticotropin-releasing factor of the sucker is strikingly conserved when compared to its counterpart from rat and differs only in two positions at the carboxyl terminus; in contrast, there is little similarity between their cryptic regions.
Video post processing architectures (2008)

This PhD thesis is not the work of a single man.Many people contributed in many ways.
New bioactive motifs and their use in functionalized self-assembling peptides for NSC differentiation and neural tissue engineering (2012)

Developing functionalized biomaterials for enhancing transplanted cell engraftment in vivo and stimulating the regeneration of injured tissues requires a multi-disciplinary approach customized for the tissue to be regenerated. In particular, nervous tissue engineering may take a great advantage from the discovery of novel functional motifs fostering transplanted stem cell engraftment and nervous fiber regeneration. Using phage display technology we have discovered new peptide sequences that bind to murine neural stem cell (NSC)-derived neural precursor cells (NPCs), and promote their viability and differentiation in vitro when linked to LDLK12 self-assembling peptide (SAPeptide). We characterized the newly functionalized LDLK12 SAPeptides via atomic force microscopy, circular dichroism and rheology, obtaining nanostructured hydrogels that support human and murine NSC proliferation and differentiation in vitro. One functionalized SAPeptide (Ac-FAQ), showing the highest stem cell viability and neural differentiation in vitro, was finally tested in acute contusive spinal cord injury in rats, where it fostered nervous tissue regrowth and improved locomotor recovery. Interestingly, animals treated with the non-functionalized LDLK12 had an axon sprouting/regeneration intermediate between Ac-FAQ-treated animals and controls. These results suggest that hydrogels functionalized with phage-derived peptides may constitute promising biomimetic scaffolds for in vitro NSC differentiation, as well as regenerative therapy of the injured nervous system. Moreover, this multi-disciplinary approach can be used to customize SAPeptides for other specific tissue engineering applications.
Structure activity relationship of antiproliferative N-acyl-beta-alanine amides. (2001)

Starting from the antiproliferative N-homofarnesoyl-beta-alanine amide 1 as a lead structure we have demonstrated that the homofarnesoyl residue of 1 can be replaced by several aliphatic and aromatic acyl moieties which offer advantages in terms of availability and stability over the original homofarnesoyl residue. The N-(2,3-dimethylphenyl) aminosulfonylphenyl moiety of 1 turned out to be essential for antiproliferative activity and cannot be replaced without complete loss of activity.
Directed assembly of carbon nanotube electronic circuits by selective area chemical vapor deposition on prepatterned catalyst electrode structures (2000)

Electron-beam lithography was used to pattern Fe thin film electrode structures on silicon dioxide covered Si wafers. The Fe film also serves as a catalyst in subsequent chemical vapor deposition of carbon nanotubes. Chemical vapor deposition was performed in a stainless steel chamber using acetylene at a partial pressure of 100 mTorr and a substrate temperature of 660 °C. Transmission electron microscopy images reveal that the carbon nanotubes grown by this method are multiwalled. The carbon nanotubes selectively grow only on the catalyst film and eventually bridge the intentionally designed micron size electrode gap forming carbon nanotube electronic circuits. The resulting devices were characterized by electronic transport measurements in a temperature range from room temperature down to 2 K.