gebhart/patrepeval huggingface dataset:
Identification of <i>Cryptococcus neoformans</i> Temperature-Regulated Genes with a Genomic-DNA Microarray (2004)

The ability to survive and proliferate at 37 degrees C is an essential virulence attribute of pathogenic microorganisms. A partial-genome microarray was used to profile gene expression in the human-pathogenic fungus Cryptococcus neoformans during growth at 37 degrees C. Genes with orthologs involved in stress responses were induced during growth at 37 degrees C, suggesting that a conserved transcriptional program is used by C. neoformans to alter gene expression during stressful conditions. A gene encoding the transcription factor homolog Mga2 was induced at 37 degrees C and found to be important for high-temperature growth. Genes encoding fatty acid biosynthetic enzymes were identified as potential targets of Mga2, suggesting that membrane remodeling is an important component of adaptation to high growth temperatures. mga2Delta mutants were extremely sensitive to the ergosterol synthesis inhibitor fluconazole, indicating a coordination of the synthesis of membrane component precursors. Unexpectedly, genes involved in amino acid and pyrimidine biosynthesis were repressed at 37 degrees C, but components of these pathways were found to be required for high-temperature growth. Our findings demonstrate the utility of even partial-genome microarrays for delineating regulatory cascades that contribute to microbial pathogenesis.
Scalp Necrosis in a Neonate Treated with Cultured Autologous Keratinocytes (1991)

A neonate compromised by a stressful labor, low birth weight, anemia, seizures, and enterocolitis developed necrosis of a caput succedaneum of the calvaria. Coverage with cultured autologous keratinocytes was successful and represents a treatment modality with minimal morbidity compared with conventional split-thickness skin grafts.
Plaque-hyaluronidase-responsive high-density-lipoprotein-mimetic nanoparticles for multistage intimal-macrophage-targeted drug delivery and enhanced anti-atherosclerotic therapy (2017)

Increasing evidence has highlighted the pivotal role that intimal macrophage (iMΦ) plays in the pathophysiology of atherosclerotic plaques, which represents an attractive target for atherosclerosis treatment. In this work, to address the insufficient specificity of conventional reconstituted high-density lipoprotein (rHDL) for iMΦ and its limited cholesterol efflux ability, we designed a hyaluronan (HA)-anchored core-shell rHDL. This nanoparticle achieved efficient iMΦ-targeted drug delivery via a multistage-targeting approach, and excellent cellular cholesterol removal. It contained a biodegradable poly (lactic-co-glycolic acid) (PLGA) core within a lipid bilayer, and apolipoprotein A-I (apoA-I) absorbing on the lipid bilayer was covalently decorated with HA. The covalent HA coating with superior stability and greater shielding was favorable for not only minimizing the liver uptake but also facilitating the accumulation of nanoparticles at leaky endothelium overexpressing CD44 receptors in atherosclerotic plaques. The ultimate iMΦ homing was achieved via apoA-I after HA coating degraded by hyaluronidase (HAase) (abundant in atherosclerotic plaque). The multistage-targeting mechanism was revealed on the established injured endothelium-macrophage co-culture dynamic system. Upon treatment with HAase in vitro, the nanoparticle HA-(C)-PLGA-rHDL exhibited a greater cholesterol efflux capacity compared with conventional rHDL (2.43-fold). Better targeting efficiency toward iMΦ and attenuated liver accumulation were further proved by results from ex vivo imaging and iMΦ-specific fluorescence localization. Ultimately, HA-(C)-PLGA-rHDL loaded with simvastatin realized the most potent anti-atherogenic efficacies in model animals over other preparations. Thus, the HAase-responsive HDL-mimetic nanoparticle was shown in this study to be a promising nanocarrier for anti-atherogenic therapy, in the light of efficient iMΦ-targeted drug delivery and excellent function of mediating cellular cholesterol efflux.
Simultaneous Determination of Conductance and Thermopower of Single Molecule Junctions (2011)

We report the first concurrent determination of conductance (G) and thermopower (S) of single-molecule junctions via direct measurement of electrical and thermoelectric currents using a scanning tunneling microscope-based break-junction technique. We explore several amine-Au and pyridine-Au linked molecules that are predicted to conduct through either the highest occupied molecular orbital (HOMO) or the lowest unoccupied molecular orbital (LUMO), respectively. We find that the Seebeck coefficient is negative for pyridine-Au linked LUMO-conducting junctions and positive for amine-Au linked HOMO-conducting junctions. Within the accessible temperature gradients (<30 K), we do not observe a strong dependence of the junction Seebeck coefficient on temperature. From histograms of thousands of junctions, we use the most probable Seebeck coefficient to determine a power factor, GS(2), for each junction studied, and find that GS(2) increases with G. Finally, we find that conductance and Seebeck coefficient values are in good quantitative agreement with our self-energy corrected density functional theory calculations.
A 55nm Ultra Low Leakage Deeply Depleted Channel technology optimized for energy minimization in subthreshold SRAM and logic (2016)

This paper presents an Ultra-Low Leakage (ULL) 55nm Deeply Depleted Channel (DDC) process technology for low power Internet of Things (IoT) applications. The DDC ULL devices provide 67% reduction in threshold (VT) variation due to Random Dopant Fluctuation (RDF). Circuit techniques such as subthreshold operation and reverse body biasing (RBB) are co-designed with the technology to maximize the energy/power saving. A test chip implements a 1Kb 6T SRAM, an FIR filter, and a 51-stage RO to showcase how the technology works with circuit techniques to minimize energy. The 6T SRAM array operates reliably down to 200mV with a reduced leakage power of 7nW (85% lower compared to non-DDC devices). The FIR filter consumes just 4.5pJ/cycle operating at 0.36V at 200 KHz.
Zero-Valent Metals Provide Possible Solution To Groundwater Problems (1995)

RETURN TO ISSUEPREVNewsNEXTZero-Valent Metals Provide Possible Solution To Groundwater Problems▪ Permeable underground barrier containing iron is proving to be an efficient and cost-effective remediation technologyELIZABETH K. WILSONView Author Information C&EN West Coast News BureauCite this: Chem. Eng. News 1995, 73, 27, 19–22Publication Date (Print):July 3, 1995Publication History Published online12 November 2010Published inissue 3 July 1995https://pubs.acs.org/doi/10.1021/cen-v073n027.p019https://doi.org/10.1021/cen-v073n027.p019newsACS PublicationsCopyright © 1995 American Chemical SocietyArticle Views25Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Groundwaters,Iron,Manufacturing,Metals,Semiconductors Get e-Alerts
Discrimination of Anterograde From Retrograde Atrial Electrograms for Physiologic Pacing (1988)

The morphology of bipolar electrograms recorded in the right atrium was examined in nine patients in an attempt to discriminate retrograde from anterograde atrial signals to an extent that would be useful for physiologic pacing. Peak-to-peak amplitude, duration, square root of energy (energy), maximum slew rate, mean slew rate, and polarity were examined in the time domain. Maximum frequency, half-power frequency, Fourier amplitude peak, and frequency of peak were measured in the frequency domain. There was a significant difference between anterograde and retrograde signals for all variables related to amplitude; these variables are peak-to-peak amplitude, energy, Fourier amplitude peak, maximum slew rate and mean slew rate. In seven of nine patients there was at least one variable sufficiently discriminating to insure reliable detection of anterograde signals while systematically rejecting retrograde signals. However, no individual variable was able to effect this discrimination in more than four patients and at least three variables were needed for all seven patients: maximum frequency, one of either energy and Fourier amplitude peak, and one of either frequency of peak or half-power frequency (six possible combinations). Thus, although differences between anterograde and retrograde atrial activity can be demonstrated in most patients, no single parameter displays sufficient discriminating power to facilitate physiologic pacing in patients exhibiting retrograde activity.
Compact and comprehensive database for ion-implanted As profile (2000)

We succeeded in explaining dose dependent As ion implantation profiles with a Monte Carlo simulation, and extracted parameters for our proposed analytical profile model from the systematic Monte Carlo data. We proposed a compact database to cover energy, dose, rotation, and oxide thickness dependence.
Interleukin-17 inhibition in psoriatic arthritis. (2015)

Greater understanding of the underlying disease process has led to the development of targeted therapeutic agents and innovative strategies in the treatment of psoriatic arthritis (PsA). This report addresses novel medications targeting the T helper 17 cell pathway, specifically those inhibiting interleukin-17A and its receptor, and discusses their role as effective therapies in the management of PsA.
Experimental Comparison of 32- and 64-QAM Constellation Shapes on a Coherent PDM Burst Mode Capable System (2011)

By introduction of an OFDM-based, data independent synchronization symbol, we implement a burst mode capable coherent transmission system. Experimental comparison of differently shaped 32-/64-QAM-constellations show a benefit up to 3 dB in OSNR-sensitivity for circular patterns.
Query Expansion Through Relevance Feedback and Local Context Analysis (2001)

Relevance feedback is the most popular query reformulation strategy. in a relevance feedback cycle, the user is presented with a list of the retrieved documents and, after examining them, marks those which are relevant In practice, only the top 10(or 20) ranked documents need to be examined. The main idea consists of selecting important terms, or expressions, attached to the documents that have been identified as relevant by the user, and of enhancing the importance of these terms in a new query formulation, The expected effect is that the new query will be moved towards the relevant documents and away from the non-relevant ones. Local analysis techniques are interesting because they take advantage of the local context provided with the query. In this regard, they seem more appropriate than global analysis techniques. In a local strategy, the documents retrieved for a given query q are examined at query time to determine terms for query expansion. This is similar to a relevance feedback cycle but might be done without assistance from the user.
Multitargeting by curcumin as revealed by molecular interaction studies (2011)

Curcumin (diferuloylmethane), the active ingredient in turmeric (Curcuma longa), is a highly pleiotropic molecule with anti-inflammatory, anti-oxidant, chemopreventive, chemosensitization, and radiosensitization activities. The pleiotropic activities attributed to curcumin come from its complex molecular structure and chemistry, as well as its ability to influence multiple signaling molecules. Curcumin has been shown to bind by multiple forces directly to numerous signaling molecules, such as inflammatory molecules, cell survival proteins, protein kinases, protein reductases, histone acetyltransferase, histone deacetylase, glyoxalase I, xanthine oxidase, proteasome, HIV1 integrase, HIV1 protease, sarco (endo) plasmic reticulum Ca(2+) ATPase, DNA methyltransferases 1, FtsZ protofilaments, carrier proteins, and metal ions. Curcumin can also bind directly to DNA and RNA. Owing to its β-diketone moiety, curcumin undergoes keto-enol tautomerism that has been reported as a favorable state for direct binding. The functional groups on curcumin found suitable for interaction with other macromolecules include the α, β-unsaturated β-diketone moiety, carbonyl and enolic groups of the β-diketone moiety, methoxy and phenolic hydroxyl groups, and the phenyl rings. Various biophysical tools have been used to monitor direct interaction of curcumin with other proteins, including absorption, fluorescence, Fourier transform infrared (FTIR) and circular dichroism (CD) spectroscopy, surface plasmon resonance, competitive ligand binding, Forster type fluorescence resonance energy transfer (FRET), radiolabeling, site-directed mutagenesis, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), immunoprecipitation, phage display biopanning, electron microscopy, 1-anilino-8-naphthalene-sulfonate (ANS) displacement, and co-localization. Molecular docking, the most commonly employed computational tool for calculating binding affinities and predicting binding sites, has also been used to further characterize curcumin's binding sites. Furthermore, the ability of curcumin to bind directly to carrier proteins improves its solubility and bioavailability. In this review, we focus on how curcumin directly targets signaling molecules, as well as the different forces that bind the curcumin-protein complex and how this interaction affects the biological properties of proteins. We will also discuss various analogues of curcumin designed to bind selective targets with increased affinity.
Image reconstruction for an electrical capacitance tomography system based on a least-squares support vector machine and a self-adaptive particle swarm optimization algorithm (2011)

The task of image reconstruction for an electrical capacitance tomography (ECT) system is to determine the permittivity distribution and hence the phase distribution in a pipeline by measuring the electrical capacitances between sets of electrodes placed around its periphery. In view of the nonlinear relationship between the permittivity distribution and capacitances and the limited number of independent capacitance measurements, image reconstruction for ECT is a nonlinear and ill-posed inverse problem. To solve this problem, a new image reconstruction method for ECT based on a least-squares support vector machine (LS-SVM) combined with a self-adaptive particle swarm optimization (PSO) algorithm is presented. Regarded as a special small sample theory, the SVM avoids the issues appearing in artificial neural network methods such as difficult determination of a network structure, over-learning and under-learning. However, the SVM performs differently with different parameters. As a relatively new population-based evolutionary optimization technique, PSO is adopted to realize parameters' effective selection with the advantages of global optimization and rapid convergence. This paper builds up a 12-electrode ECT system and a pneumatic conveying platform to verify this image reconstruction algorithm. Experimental results indicate that the algorithm has good generalization ability and high-image reconstruction quality.
Eukaryotic systems broaden the scope of synthetic biology (2009)

Synthetic biology aims to engineer novel cellular functions by assembling well-characterized molecular parts (i.e., nucleic acids and proteins) into biological "devices" that exhibit predictable behavior. Recently, efforts in eukaryotic synthetic biology have sprung from foundational work in bacteria. Designing synthetic circuits to operate reliably in the context of differentiating and morphologically complex cells presents unique challenges and opportunities for progress in the field. This review surveys recent advances in eukaryotic synthetic biology and describes how synthetic systems can be linked to natural cellular processes in order to manipulate cell behavior and to foster new discoveries in cell biology research.
Android Application Development Processes and Tool Chains for Intel® Architecture (2014)

This chapter introduces Android† application development on Intel hardware platforms. Developing Android system applications requires some special development, debugging, and performance analysis tools, and the development environment and object formats are different from those of general-purpose desktop computers. Before developing Android applications, we need to learn about the development process of Android system applications.
The thermocoax cable as the microwave frequency filter for single electron circuits (1995)

We have analyzed the possibility of using the resistive coaxial cable, Thermocoax(R) Philips as a microwave cryofilter for single electron experiments performed in a top-loading system dilution refrigerator. The biasing and signal lines made of this cable are assumed to link a single electron device kept at the lowest temperature Td to the rf filter having a temperature Tf of several kelvin. The attenuation in a wide frequency range has been calculated and it turned out that a 40-cm-long piece of this cable with an outer diameter of 0.5 mm could drastically reduce the effect of noise from the 50 Ω source anchored at Tf (below 25 K), making its effect comparable with the effect of the thermal fluctuations in the device for Td≊40 mK. The calculated attenuation is in reasonable agreement with the data measured at frequencies up to 18 GHz.
Key Role of the Lewis Base Position in Asymmetric Bifunctional Catalysis:  Design and Evaluation of a New Ligand for Chiral Polymetallic Catalysts (2006)

New chiral ligands for asymmetric polymetallic catalysts were designed on the basis of the assumption that the higher-order assembly structure is stabilized by modifying the modular unit. The designed ligands 6 and 7 contained a scaffolding cyclohexane ring with a Lewis base phosphine oxide directly attached to the scaffold. A module in the polymetallic complex contains two metals per ligand, and a stable 6-, 5-, 5-membered fused chelation ring system should be generated. Synthesis of these ligands is simple and high yielding, using a catalytic dynamic kinetic resolution promoted by the Trost catalyst as a key step. Ligand function was assessed in a catalytic asymmetric ring-opening reaction of meso-aziridines with TMSCN, a useful reaction for the synthesis of optically active β-amino acids. The Gd complex generated from Gd(OiPr)3 and the ligand was a highly active and enantioselective catalyst in this reaction. Enantioselectivity was reversed compared to the previously reported d-glucose-derived catalyst containing the same chirality of the individual module. ESI-MS analysis and X-ray crystallographic studies indicate that the assembly state of the modules in the polymetallic catalysts differs depending on the chiral ligand. The difference in the higher-order structure stems from a subtle change (one carbon) in the position of the Lewis base relative to the Gd metal. The change in the higher-order structure of the polymetallic complex led to a dramatic reversal of the enantioselectivity and increased catalyst activity.
Process mining in business process management: Concepts and challenges (2013)

Process mining is an emerging research area that aims to improve the analysis of Business Process Models (BPMs) by extracting knowledge from event logs. What actually happened in the organization is set forth for consideration, not what people think about the organization. Therefore, it can be used in various industrial and scientific applications. This paper aims to provide information about the process mining concept, by revealing the differences with data mining, which is more commonly known in the literature, to point out the challenges in the use of BPM, to introduce the studies on this subject, to serve as a guide and to provide meta-information for researchers, scientists, software developers, etc. who are interested in the process mining.
2211 Study on Path Tracking Control Using Four-Wheel Steering System (2000)

This paper proposes a vehicle path tracking control system for vehicle equipped with four-wheel steering (4WS) system. Although conventional front-wheel steering vehicle can be employed for path tracking, it is impossible to achieve desirable control performance in both lateral and yaw motion from the viewpoint of vehicle dynamics and control. On the other hand, steering the rear wheels permits the vehicle path and attitude to be controlled independently of each other. Based on this merit, 4WS path tracking control system is designed via coordinate transformation to decouple lateral motion and yaw motion during path tracking maneuver. Finally, its validation and effectiveness are investigated by computer simulation.
ChemInform Abstract: High‐Enantioselective Synthesis of Pyrrolidine Derivatives as Chiral Building Blocks. (1990)

Abstract Starting with the Z‐benzyloxypentenol (I) or its E‐isomer (IX), the diastereomeric epoxides (II) and (X) are prepared.
Towards an “Internet of Things” framework for financial services sector (2016)

The ability to apply state-of-the-art Internet of Things (IoT) technology to extract customer insights through analytics by shaping the information into consumables for other connected systems is creating a lot of opportunities for banking and financial services. This paper presents an architecture based on Internet of Things for banking and finance sector by managing, mobile, household devices, wearable sensors and other sensing devices for various applications including retail banking, insurance, and investments. We have presented a case study of different banking applications flow with IoT-intelligence by analyzing users' data. In addition, we have a mapping of the proposed architecture onto the various applications of banks and financial services.
Fundamental Electronic Properties and Applications of Single-Walled Carbon Nanotubes (2002)

Recent scanning tunneling microscopy studies of the intrinsic electronic properties of single-walled carbon nanotubes (SWNTs) are overviewed in this Account. A brief theoretical treatment of the electronic properties of SWNTs is developed, and then the effects of finite curvature and broken symmetry on electronic properties, the unique one-dimensional energy dispersion in nanotubes, the interaction between local spins and carriers in metallic nanotubes systems, and the atomic structure and electronic properties of intramolecular junctions are described. The implications of these studies for understanding fundamental one-dimensional physics and future nanotube device applications are also discussed.
Compact stub type microstrip bandpass filter using defected ground plane (2004)

Usually a defected ground plane structure (DGS) provides only a band-reject response. However, in this work we introduce a simple band-accept circuit element in the DGS and developed a microstrip stub type compact 3-pole bandpass filter (BPF) at 4.2 GHz. The BPF has bandwidth and insertion loss 38% and 0.6 dB respectively. It has better than 25 dB rejection in the stopband up to 12 GHz.