gebhart/patrepeval huggingface dataset:
Modulation of IL-12 and IFN-γ Secretions by Eleutheroside E, Tortoside A, and Syringaresinol from Acanthopanax koreanum Nakai (2010)

Acanthopanax koreanum Nakai (Araliaceae) is a medicinal plant indigenous to Korea. The root and stem barks of Acanthopanax species have been used as a tonic and sedative as well as in the treatment of rheumatism and diabetes. In our study, three lignans, eleutheroside E (EE), tortoside A (TA), and syringaresinol (SY), were isolated from the stem and root of A. koreanum in an effort to study the immunomodulating effect. We treated natural killer cells and dendritic cells with lignans (EE, TA, or SY), and analyzed their cytokine (IL-12 and IFN-<TEX>${\gamma}$</TEX>) secretion. EE, TA, or SY markedly enhanced IL-12 secretion in mouse lymphoid (DC1) and myeloid type (DC2.4) dendritic cells after 48 hr of treatment. There were no significant differences in the cytokine stimulatory effects between EE, TA, or SY. Moreover, treatment of EE, TA, or SY significantly induced IFN-<TEX>${\gamma}$</TEX> secretion by human NK cells (NK92MI) confirmed by ELISA assay. This study suggests that lignans from A. koreanum modulate cytokines, and that such modulation may provide the mechanism of action for many of their therapeutic effects.
Two Synergistic Activation Mechanisms of α2β1 Integrin-mediated Collagen Binding (2007)

Activation of protein kinase C by 12-O-tetradecanoylphorbol-13-acetate (TPA) induces ligand-independent aggregation of a cell surface collagen receptor, alpha2beta1 integrin. Concomitantly, TPA increases the avidity of alpha2beta1 for collagen and the number of conformationally activated alpha2beta1 integrins. The structural change was shown using a monoclonal antibody 12F1 that recognizes the "open" (active) conformation of the inserted domain in the alpha2 subunit (alpha2I). Amino acid residue Glu-336 in alpha2 subunit is proposed to mediate the interaction between alpha2I domain and beta1 subunit. Glu-336 seems to regulate a switch between open and "closed" conformations, since the mutation alpha2E336A inhibited the TPA-related increase in the number of 12F1 positive integrins. E336A also reduced cell adhesion to collagen. However, E336A did not prevent the TPA-related increase in adhesion to collagen or alpha2beta1 aggregation. Thus, alpha2beta1 integrin avidity is regulated by two synergistic mechanisms, first an alpha2E336-dependent switch to the open alpha2I conformation, and second an alpha2E336-independent mechanism temporally associated with receptor aggregation.
Modifying chemical vapor deposited diamond films for field emission displays (1998)

A systematic investigation of deposition parameters and post-treatments was performed for the development of field emission displays based on flat chemical vapor deposited diamond films. The lowest onset field strengths were obtained for films grown at the highest substrate temperature, highest methane content, and with negatively biased substrate. Intentionally damaging the films by implantation with 50 keV and 100 keV carbon ions as well as with 4.4 MeV silicon ions usually resulted in an enhanced field emission. The emission followed the Fowler–Nordheim law up to 0.5 mA/mm2, and a current carrying ability of more than 100 mA/mm2 was detected. Considerably improved emission was achieved by short and long-term processing at higher current levels.
Efficient data-structures and parallel algorithms for association rules discovery (2004)

Discovering patterns or frequent episodes in transactions is an important problem in data mining for the purpose of infering deductive rules from them. Because of the huge size of the data to deal with, parallel algorithms have been designed for reducing both the execution time and the number of repeated passes over the database in order to reduce, as much as possible, I/O overheads. In this paper, we introduce approaches for the implementation of two basic algorithms for association rules discovery (namely Apriori and Eclat). Our approaches combine efficient data structures to code different key information (line indexes, candidates) and we exhibit how to introduce parallelism for processing such data-structures.
FSED-feature selective edge detection (2002)

We present a method that finds edges between certain image features, e.g. gray-levels, and disregards edges between other features. The method uses a channel representation of the features and performs normalized convolution using the channel values as certainties. This means that areas with certain features can be disregarded by the edge filter. The method provides an important tool for finding tissue specific edges in medical images, as demonstrated by an MR-image example.
METROPOLITAN PLANNING FOR EDUCATION (1966)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsHerman R. GoldbergThe author is superintendent of schools, Rochester, New York. The article is the major part of remarks presented as a participant at a conference of the Harvard Chapter of Pi Lambda Theta, Harvard Graduate School of Education , December 11, 1965
Electronic Structure Calculations of InP-Based Coupled Quantum Dot-Quantum Well Structures (2016)

In this work we investigate the electronic structure of coupled 0D-2D nanostructures. The respective confined state energy levels in a quantum dot-quantum well system are calculated for various conduction band offsetsbetween the quantum dot and surrounding material. The calculated electron and hole energy levels with their wave functions allow determining if the wave functions are within the injector quantum well or within the quantum dot and if the carrier positions on the energy scale are appropriate from the point of view of a possible laser structure utilizing the so-called tunnel injection scheme. It is shown that for an adequate width of an injector quantum well and the conduction band offsets designing an optimal tunnel injection structure is possible.
Crystal structure and CRISPR RNA-binding site of the Cmr1 subunit of the Cmr interference complex (2014)

A multi-subunit ribonucleoprotein complex termed the Cmr RNA-silencing complex recognizes and destroys viral RNA in the CRISPR-mediated immune defence mechanism in many prokaryotes using an as yet unclear mechanism. In Archaeoglobus fulgidus, this complex consists of six subunits, Cmr1-Cmr6. Here, the crystal structure of Cmr1 from A. fulgidus is reported, revealing that the protein is composed of two tightly associated ferredoxin-like domains. The domain located at the N-terminus is structurally most similar to the N-terminal ferredoxin-like domain of the CRISPR RNA-processing enzyme Cas6 from Pyrococcus furiosus. An ensuing mutational analysis identified a highly conserved basic surface patch that binds single-stranded nucleic acids specifically, including the mature CRISPR RNA, but in a sequence-independent manner. In addition, this subunit was found to cleave single-stranded RNA. Together, these studies elucidate the structure and the catalytic activity of the Cmr1 subunit.
Polymer–Lipid Hybrid Vesicles and Their Interaction with HepG2 Cells (2020)

Polymer-lipid hybrid vesicles are an emerging type of nano-assemblies that show potential as artificial organelles among others. Phospholipids and poly(cholesteryl methacrylate)-block-poly(methionine methacryloyloxyethyl ester (METMA)-random-2-carboxyethyl acrylate (CEA)) labeled with a Förster resonance energy transfer (FRET) reporter pair are used for the assembly of small and giant hybrid vesicles with homogenous distribution of both building blocks in the membrane as confirmed by the FRET effect. These hybrid vesicles have no inherent cytotoxicity when incubated with HepG2 cells up to 1.1 × 10<sup>11</sup> hybrid vesicles per mL, and they are internalized by the cells. In contrast to the fluorescent signal originating from the block copolymer, the fluorescent signal coming from the lipids is barely detectable in cells incubated with hybrid vesicles for 6 h followed by 24 h in cell media, suggesting that the two building blocks have a different intracellular fate. These findings provide important insight into the design criteria of artificial organelles with potential structural integrity.
Autologous implant of peritoneal mesothelium in rabbits and man. (1990)

With the purpose of studying peritoneal physiology, original biopsy methods were devised and human and rabbit peritoneal mesothelial cells cultured and characterized. It was then decided to verify whether these cells could be implanted autologously during peritoneal dialysis in cases of acute loss of mesothelial surface. Staphylococcal peritonitis was induced in 12 rabbits and after 4 days of antibiotics, 6 of them were autoimplanted with cultured mesothelial cells, previously marked in 3 cases with thymidine (H3TdR). Implanted rabbits sacrificed after 3 and 6 days showed taking of the new mesothelial cells both by direct morphological observation and by autoradiography. Four uremic CAPD patients recovering from severe peritonitis were implanted with 300 million of their own peritoneal mesothelial cells, previously cultured and frozen. Morphological signs of taking were evident by laparoscopy and from peritoneal biopsies performed 3 and 6 days after implant. The fact that such implants are possible may have interesting applications in medicine and surgery.
Cardiovascular effects of two xanthines and the relation to adenosine antagonism (1989)

We hypothesize that the hemodynamic effects of xanthine derivatives depend on their ability to antagonize the vasodilating effects of endogenous adenosine. In a randomized, double-blind, and placebo-controlled study of 10 normotensive volunteers caffeine, a xanthine with in vitro adenosine antagonistic properties, increased mean arterial pressure by 5.6 +/- 0.9 mm Hg and lowered heart rate by 5.3 +/- 1.1 beats/min. After administration of enprofylline, a xanthine without adenosine antagonism, forearm vascular resistance decreased by 5.6 +/- 3.4 IU, heart rate increased by 10.6 +/- 2.6 beats/min, and plasma adrenaline, plasma noradrenaline, and renin activity increased by 178 +/- 86%, 14 +/- 8%, and 36 +/- 13%, respectively. Adenosine infusion alone induced a dose-related increase in pulse pressure and heart rate, and it increased plasma adrenaline and noradrenaline by 186 +/- 77% and 132 +/- 55%, respectively. This response to adenosine was reduced by pretreatment with caffeine but not enprofyline. Thus opposite circulatory responses to caffeine and enprofylline occurred, with signs of vasoconstriction and vasodilation, respectively. In addition, caffeine, but not enprofylline, reduced the cardiovascular response to exogenous adenosine.
Absence of acute ocular damage in humans after prolonged exposure to intense RF EMF (2015)

The eye is considered to be a critical organ when determining safety standards for radio frequency (RF) radiation. Experimental data obtained using animals showed that RF heating of the eye, particularly over a specific threshold, can induce cataracts. During the treatment of cancer in the head and neck by hyperthermia, the eyes receive a considerable dose of RF radiation due to stray radiation from the prolonged (60 min) and intense exposure at 434 MHz of this region. In the current study, we verified the exposure guidelines for humans by determining the association between the electromagnetic and thermal dose in the eyes with the reported ocular effects. We performed a simulation study to retrospectively assess the specific absorption rate (SAR) and temperature increase in the eyes of 16 selected patients (encompassing a total of 74 treatment sessions) whose treatment involved high power delivery as well as a minimal distance between the tumor site and the eye. Our results show that the basic restrictions on the peak 10 g spatial-averaged SAR (10 W kg(-1)) and peak tissue temperature increase (1 °C) are exceeded by up to 10.4 and 4.6 times, on average, and by at least 6.2 and 1.8 times when considering the lower limit of the 95% confidence interval. Evaluation of the acute effects according to patients' feedback (all patients), the common toxicity criteria scores (all patients) and an ophthalmology investigation (one patient with the highest exposure) revealed no indication of any serious acute ocular effect, even though the eyes were exposed to high electromagnetic fields, leading to a high thermal dose. We also found that, although there is a strong correlation (R (2) = 0.88) between the predicted induced SAR and temperature in the eye, there are large uncertainties regarding the temperature-SAR relationship. Given this large uncertainty (129%) compared with the uncertainty of 3D temperature simulations (61%), we recommend using temperature simulations as a dosimetric measure in electromagnetic exposure risk assessments.
Gender, Sex and Sexuality in the Assessment of Prospective Carers (1992)

Argues that issues of gender, sex and sexuality have direct implications for children placed with carers and offers points to be kept in mind when approaching these areas with prospective carers.
Electrically Driven Automotive Air Conditioner (1987)

<div class="htmlview paragraph">In recent years, the fraction of air conditioning systems installed in American automobiles has increased to approximately 85%. Concurrently, efforts to improve fuel economy have resulted in smaller engines. The point has been reached in which load from a cycling fixed-displacement compressor can significantly affect vehicle drivability and performance. To remedy this problem, variable-capacity A/C systems have been developed with mechanically controlled compressor displacements.</div> <div class="htmlview paragraph">An alternative electronic approach to cooling capacity modulation is presented in this paper. The system utilizes a variable-speed brushless dc motor to drive a fixed-displacement compressor, thus achieving continuous control of cooling output independent of the engine drive belt. Compared to variable-displacement compressors, electrically driven A/C systems provide the following additional benefits: <ul class="list disc"> <li class="list-item"><div class="htmlview paragraph">Hermetic motor/compressor assembly (no shaft seal leakage)</div></li> <li class="list-item"><div class="htmlview paragraph">Smaller, less complex compressor</div></li> <li class="list-item"><div class="htmlview paragraph">Flexible packaging (no drive belt)</div></li> <li class="list-item"><div class="htmlview paragraph">Full cooling capacity at any engine speed</div></li> <li class="list-item"><div class="htmlview paragraph">Control of conditioned air temperature without reheat</div></li> </ul></div> <div class="htmlview paragraph">This paper deals with the development of a brushless dc drive system suitable for powering an automotive air conditioner. Two 5 hp motors were designed and built with maximum operating speeds of 6000 and 7000 rpm. These motors were then tested in a typical automotive air conditioning system over a range of operating conditions in order to determine their performance envelopes. The results are discussed, and conclusions are drawn as to the type of compressor and control strategy best suited for electric automotive A/C. Issues that are critical to the further development of electrically driven A/C systems are identified. An example simulation of annualized A/C system performance is also provided to quantify some of the benefits of cooling capacity modulation.</div>
Effectiveness of Resins in Neutralizing Antibiotic Activities in Bactec Plus Aerobic/F Culture Medium (1998)

Incorporating resins in blood culture media can effectively reduce the activities of several antibiotics. It was shown that the activities of some generally used antibiotics decreased by 80 to 90% within 2 h in Bactec Plus Aerobic/F resin-containing culture medium. Bactec vials containing resins were still found to be positive for bacteria when antibiotics were present. The addition of beta-lactamase shortened the detection time irrespective of the presence of resins.
Refinement of a DNA based Alzheimer disease epitope vaccine in rabbits (2013)

We previously demonstrated that our second-generation DNA-based Alzheimer disease (AD) epitope vaccine comprising three copies of a short amyloid-β (Aβ) B cell epitope, Aβ 11 fused with the foreign promiscuous Th epitope, PADRE (p3Aβ 11-PADRE) was immunogenic in mice. However, since DNA vaccines exhibit poor immunogenicity in large animals and humans, in this study, we sought to improve the immunogenicity of p3Aβ 11-PADRE by modifying this vaccine to express protein 3Aβ 11-PADRE with a free N-terminal aspartic acid fused with eight additional promiscuous Th epitopes. Generated pN-3Aβ 11-PADRE-Thep vaccine has been designated as AV-1955. We also delivered this vaccine using the TriGrid electroporation system to improve the efficiency of DNA transfection. This third-generation DNA epitope vaccine was evaluated for immunogenicity in rabbits in comparison to the parent construct p3Aβ 11-PADRE. AV-1955 vaccination induced significantly stronger humoral immune responses in rabbits compared with p3Aβ 11-PADRE vaccine. Anti-Aβ 11 antibodies recognized all forms of human β-amyloid peptide (monomers, oligomers and fibrils), bound to amyloid plaques in brain sections from an AD case and reduced oligomer- and fibril-mediated cytotoxicity ex vivo. These findings suggest that AV-1955 could represent an effective DNA epitope vaccine for AD therapy, pending safety and efficacy studies that are currently being conducted in Rhesus monkeys.
[Persistent vegetative state: medical, moral, legal and economic aspects]. (1998)

The classical definition of persistent vegetative state describes patient who is wakeful but not awake, and indicates intact function of the brain stem and no function of brain cortex. The presence and the degree of awareness is most difficult to assess and causes moral and legal controversies concerning the management of persistent vegetative state. The absence of the perceptual awareness may be the most important clinical characterization for diagnosis. Differential diagnosis includes coma, brain death, locked-in syndrome and minimally responsive state. The pressure of economical factors (managed care) on medical care makes this problem even more complicated.
A flexible approach to short-term hydro-thermal coordination. II. Dual problem solution procedure (1996)

The dual problem formulation is the crucial point in all Lagrangian relaxation based hydro-thermal generation coordination approaches. Such an approach is presented in Part I of this work. In this paper, an original dual problem solution procedure is presented. The dual is divided into independent thermal and hydro subproblems. Thermal subproblems are solved using the dynamic programming method. Hydro subproblems are treated by employing the special approximation in the state-space within the multi-pass dynamic programming method. Particular attention is paid to hydraulically coupled reservoirs. The special structure of these hydro subproblems is used and the successive approximation is applied to make the dynamic programming method more effective. Simulations performed on a realistic power system are presented to illustrate the efficiency of the proposed approach and the sensitivity of the dual problem solution regarding values of Lagrangian multipliers.
Noncontact sheet resistance measurement technique for wafer inspection (1995)

A new technique, MICROTHERM, has been developed for noncontact sheet resistance measurements of semiconductor wafers. It is based on the application of microwave energy to the wafer, and simultaneous detection of the infrared radiation resulting from ohmic heating. The pattern of the emitted radiation corresponds to the sheet resistance distribution across the wafer. This method is nondestructive, noncontact, and allows for measurements of very small areas (several square microns) of the wafer.
Constrained non-linear optimization by modified particle swarm optimization (2007)

This paper presents a modified particle swarm optimization (MPSO) for constrained non-linear optimization problems. Optimization problems are very complex in real life applications. The proposed modified PSO consists of problem (complexity) dependent variable number of promising values (in velocity vector), error-iteration dependent step length, unlocking the dead look of idle particles and so on. It reliably and accurately tracks a continuously changing solution of the complex function and no extra concentration/effort is needed for more complex higher order functions. Constraint management is incorporated in the modified PSO by penalty function. The modified PSO has balance between local and global searching abilities, and an appropriate fitness function helps to converge it quickly. To avoid the method to be frozen, stagnated/idle particles are reset. Finally, benchmark data and methods are used to show the effectiveness of the proposed method.
Three-dimensional nanoarchitecture of Sn–Sb–Co alloy as an anode of lithium-ion batteries with excellent lithium storage performance (2012)

A novel nanoarchitectured Sn–Sb–Co alloy electrode is reported, which was prepared by direct electrodeposition on a Cu nanoribbon array in order to target the rapidly fading capacity and the poor rate-capability issues of Sn based materials for Li-ion batteries. The SEM images indicate a three-dimensional (3D) nanoarchitectured Sn–Sb–Co alloy with an array structure. Electrochemical measurements show that the 3D nanoarchitectured Sn54Sb41Co5 alloy electrode exhibits a reversible capacity as high as 512.8 mA h g−1 at 0.2 C (1 C = 650 mA g−1) after 150 cycles. Furthermore, the 3D nanoarchitectured Sn54Sb41Co5 anode can deliver a high reversible capacity (275 mA h g−1) up to the 80th cycle at a high discharge–charge rate of 23 C (∼15 A g−1). These outstanding electrochemical properties are attributed to the unique nanoarchitectures of the Sn54Sb41Co5 electrodes, making them an excellent anode material.
Antioxidant Potential of Qizhu Tang, a Chinese Herbal Medicine, and the Effect on Cerebral Oxidative Damage after Ischemia Reperfusion in Rats. (2001)

A traditional Chinese herbal medicine, Qizhu Tang (QZT) was studied for its in vitro antioxidant activity and the effect on cerebral oxidative damage after forebrain ischemia followed by reperfusion in rats. The QZT decoction was shown to have strong hydroxyl radical (*OH) scavenging activity (approx. 0.1 mM as Trolox equivalent) when determined by ESR using DMPO as a spin trap reagent and H2O2/UV as the *OH source. When the QZT decoction was injected into rat duodenum 2 h before cerebral ischemia, the oxidative brain damage after 45 min reperfusion was strongly inhibited in terms of two biochemical indications, thiobarbituric acid reactive substance formation and the loss of glutathione peroxidase. Since the QZT formula consists of 4 herbal constituents (Rhizoma atractylodis, Poria, Radix notoginseng and Radix astragali), each of the component herbs and their combinations were also examined for their protective effects on the cerebral ischemia/reperfusion injury and the effects were compared with their in vitro antioxidant potential. Although some of the incomplete formulas showed as strong antioxidant activities as complete QZT in vitro, only the complete QZT formula was effective in preventing cerebral oxidative injury in rats, and other preparations showed limited activity in vivo.
Family physicians' interests in special features of electronic publication. (2003)

Primary care-oriented journals should consider the interests of family physicians when developing and offering electronic features for their readers.