gebhart/patrepeval huggingface dataset:
A Built-In Self-Testing Method for Embedded Multiport Memory Arrays (2005)

With recent advances in semiconductor technologies, the design and use of memories for realizing complex system-on-a-chip (SoC) is very widespread. The growing need for storage in computer, communication, and network appliances has motivated new advancements in faster and more efficient ways to test memories. Efficient testing schemes for single-port memories have been readily available. Multiport memories are widely used in multiprocessor systems, telecommunication application-specific integrated circuits (ASICs), etc. Research papers which define multiport memory fault models and give march tests for the same are currently available. However, little work has been done to use the power of serial interfacing for testing multiport memories. In this paper, we develop a powerful test architecture for two-port memories using the serial interfacing technique. Based on the serial testing mechanism, we propose new march algorithms which can prove effective to reduce hardware cost considerably for a chip with many two-port memories. Once we understand how serial interfacing helps test two-port memories, one possible extension is to use serial interfacing for p-port memories (p > 2). The proposed method based on the serial interfacing technique has the advantages of high fault coverage, low hardware overhead, and tolerable test application time.
ChemInform Abstract: SYNTHESIS OF ERYTHRININ‐A AND RELATED ISOFLAVONES (1985)

Abstract Durch Prenylierung des Desoxybenzoins (I) wird ein Gemisch aus (IIIa), (IIIb) und (IIIc) erhalten.
The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis) (2016)

Increased fetal hemoglobin levels lessen the severity of symptoms and increase the lifespan of patients with sickle cell disease. Hydroxyurea, the only drug currently approved for the treatment of sickle cell disease, is not effective in a large proportion of patients and therefore new pharmacological agents that increase fetal hemoglobin levels have long been sought. Recent studies identifying LSD-1 as a repressor of γ-globin expression led to experiments demonstrating that the LSD-1 inhibitor RN-1 increased γ-globin expression in the sickle cell mouse model. Because the arrangement and developmental stage-specific expression pattern of the β-like globin genes is highly conserved between man and baboon, the baboon model remains the best predictor of activity of fetal hemoglobin-inducing agents in man. In this report, we demonstrate that RN-1 increases γ-globin synthesis, fetal hemoglobin, and F cells to high levels in both anemic and non-anemic baboons with activity comparable to decitabine, the most potent fetal hemoglobin-inducing agent known. RN-1 not only restores high levels of fetal hemoglobin but causes the individual 5' Iγ- and 3' Vγ-globin chains to be synthesized in the ratio characteristic of fetal development. Increased fetal hemoglobin was associated with increased levels of acetylated Histone H3, H3K4Me2, H3K4Me3, and RNA polymerase II at the γ-globin gene, and diminished γ-globin promoter DNA methylation. RN-1 is likely to induce clinically relevant levels of fetal hemoglobin in patients with sickle cell disease, although careful titration of the dose may be required to minimize myelotoxicity.
Analysis and application of a new control method for continuous-mode boost converters in power factor correction circuits (2002)

Most unity power factor rectifiers require a current control loop in order to realize a sinusoidal mains current. This contribution deals with a realization of a new control method which is characterized through a sinusoidal mains current for continuous-mode boost converters by controlling only their DC-output voltage.
On the kernel MUSIC algorithm (2002)

The kernel MUSIC (multiple signal classification) algorithm was proposed as an improvement over the existing MUSIC algorithm. The proposed algorithm is based on the orthogonality between the image and kernel space of an Hermitian mapping constructed from a signal. The major part of the computation is Gaussian elimination of a matrix, the required processing time as a function of data number grows slower than that of the existing MUSIC based on eigenstate analysis. And thus this algorithm is advantageous for processing large size data. This algorithm was applied to image reconstruction process of a laser radar and its superior spatial resolution higher than that limited by the wavelength scanning range was demonstrated.
PLASTIC TRACHEOSTOMY BUTTON (1957)

Patients, after laryngectomy, sometimes have difficulty maintaining an adequate size of tracheal stoma. Various reasons for this are (1) a poorly constructed stoma, (2) postoperative infection at the skin mucosal line leading to a contracture ring, (3) spontaneous keloid formation, (4) poor healing in patients who have previously undergone irradiation for cancer of the larynx, and (5) refusal by the patient to undergo tracheal stomal revision. Obviously, the best treatment for a constricting tracheal stoma is operative revision of the stoma. In most cases this is successful, if careful skin-to-mucosa approximation is achieved without postoperative infection. The handling of this problem is well discussed by Martin.<sup>1</sup>The ideal tracheal stoma, of course, closely approximates the diameter of the trachea itself and requires no tubing. However, for the reasons listed above, a few patients do not secure an adequate tracheal-skin opening. Unless they wear standard tracheostomy tubes, the stoma soon
The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols (2011)

Since Dnnmt3a has been associated with development, cancer and brain function, these data suggest a biochemical mechanism for the beneficial health effect of black tea and coffee and a possible molecular mechanism for the improvement of brain performance and mental health by dietary polyphenols.
76 GHz post-wall waveguide fed parallel plate slot array with 45 degree linear polarization (2002)

We propose a new configuration of one radiating slot and two reflection-canceling slots for degree linear polarization in post-wall waveguide fed parallel plate slot arrays. Uniform aperture field has been obtained in a 76 GHz model antenna with a 5 cm-square area. Cross polarization is suppressed below -26 dB in the boresight. A peak gain of 29.8 dBi is realized with 46.4% efficiency.
Different patterns of hyperalgesia induced by experimental inflammation in human skin (1994)

Different types of hyperalgesia were studied after experimental induction of inflammation in small skin areas of healthy volunteers either by topical application of capsaicin solution (1% in 70% ethanol) or by briefly freezing a skin area of similar size to -28 degrees C. Sensory tests were performed 30 min after capsaicin application and 22 h after freeze lesions. Heat pain thresholds were lowered after both treatments, probably due to nociceptor sensitization. Hyperalgesia to four types of mechanical stimulation was studied. (i) Hyperalgesia to punctate stimuli was encountered at the skin site directly affected by the noxious chemical or freeze stimulus (1 degree zone) and in the surrounding skin (2 degrees zone) in both models though the area of 2 degrees hyperalgesia to punctate stimuli after freezing was smaller than after capsaicin. (ii) Hyperalgesia to gently brushing the skin was prominent after capsaicin in 1 degree and 2 degrees zone, but almost absent after freezing. It was concluded that both hyperalgesia to punctate stimuli and brush-evoked pain are due to central nervous plasticity changes rather than nociceptor sensitization. As revealed by differential nerve blocks, brush-evoked pain is mediated by low threshold mechanosensitive A beta-fibres, whilst hyperalgesia to punctate stimuli can be elicited when only C-fibres conduct. In contrast to hyperalgesia to punctate stimuli it requires continuous background discharges in nociceptor units. (iii) Pressure hyperalgesia to tonic stimulation with a blunt probe was encountered in the 1 degree zone of both types of inflammation and is probably due to recruitment of sensitized nociceptor units. (iv) Impact hyperalgesia was studied by shooting small bullets against the skin at predetermined velocities. It was found in the 1 degree zone after freezing and absent in the capsaicin model. Differential nerve blocks revealed that it is probably mediated by sensitized C-fibres. In conclusion, different types of inflammatory changes may result in characteristic different patterns of hyperalgesia.
von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish (2010)

Biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene predisposes human patients to the development of highly vascularized neoplasms in multiple organ systems. We show that zebrafish vhl mutants display a marked increase in blood vessel formation throughout the embryo, starting at 2 days post-fertilization. The most severe neovascularization is observed in distinct areas that overlap with high vegfa mRNA expression, including the vhl mutant brain and eye. Real-time quantitative PCR revealed increased expression of the duplicated VEGFA orthologs vegfaa and vegfab, and of vegfb and its receptors flt1, kdr and kdr-like, indicating increased vascular endothelial growth factor (Vegf) signaling in vhl mutants. Similar to VHL-associated retinal neoplasms, diabetic retinopathy and age-related macular degeneration, we show, by tetramethyl rhodamine-dextran angiography, that vascular abnormalities in the vhl(-/-) retina lead to vascular leakage, severe macular edema and retinal detachment. Significantly, vessels in the brain and eye express cxcr4a, a marker gene expressed by tumor and vascular cells in VHL-associated hemangioblastomas and renal cell carcinomas. VEGF receptor (VEGFR) tyrosine kinase inhibition (through exposure to sunitinib and 676475) blocked vhl(-/-)-induced angiogenesis in all affected tissues, demonstrating that Vegfaa, Vegfab and Vegfb are key effectors of the vhl(-/-) angiogenic phenotype through Flt1, Kdr and Kdr-like signaling. Since we show that the vhl(-/-) angiogenic phenotype shares distinct characteristics with VHL-associated vascular neoplasms, zebrafish vhl mutants provide a valuable in vivo vertebrate model to elucidate underlying mechanisms contributing to the development of these lesions. Furthermore, vhl mutant zebrafish embryos carrying blood vessel-specific transgenes represent a unique and clinically relevant model for tissue-specific, hypoxia-induced pathological angiogenesis and vascular retinopathies. Importantly, they will allow for a cost-effective, non-invasive and efficient way to screen for novel pharmacological agents and combinatorial treatments.
Polymorphism of the Bovine POU1F1 Gene: Allele Frequencies and Effects on Milk Production in Three Iranian Native Breeds and Holstein Cattle of Iran (2007)

The aim of this study was to estimate the allele frequencies in polymorphic site of exon six of POU1F1 gene in three Iranian native and Holstein cattle. Genomic DNA was extracted from 3 Iranian native cattle breeds, including 97 Mazandarani, 87 Sarabi, 112 Golpaygani and also 110 Holstein cattle. A 451 bp fragment of intron 5 and exon 6 were amplified and digested with HinfI restriction enzyme. Frequencies of allele A were 0.37, 0.27, 0.34 and 0.21 for Mazandarani, Sarabi, Golpaygani and Holstein cattle, respectively. Significant differences in genotype frequencies were found between Mazandarani or Golpaygani and Holstein cattle. No significant differences in genotype frequencies were found between Sarabi and Holstein cattle. Transition A to G in nucleotide 1256 is responsible for HinfI(-) allele. No significant association was observed between POU1F1 polymorphism and milk production. Differences in allelic frequency between native Bos indicus breeds (Mazandarani, Golpaygani) and Holstein at the present study might be due to differences in origin breeds, low number of samples and/or as the effect of natural selection in native breeds.
Development of the electromagnetic technology for broken rail detection from a mobil platform (2016)

Timely detection of breaks in running rails remains a topic of significant importance for the railroad industry. GE has been investigating new ideas of the Rail Integrity Monitoring or RIM technology that can be implemented on a wide range of the rolling stock platforms including locomotives, passenger and freight cars. The focus of the project is to establish a simple, non-contact, and inexpensive means of nondestructive inspection by fusion of known solutions with new technology development that can result in detection with high reliability. A scaled down model of a typical locomotive-track system has been developed at GE Global research for detailed study of the detection process. In addition, a finite element model has been established and used to understand distribution of the magnetic field and currents in such a system. Both models have been using the rails and wheel-axles geometry to establish a realistic model that would provide the electric current and magnetic field distribution close to the real world phenomenon. Initial magnetic field maps were obtained by scanning a 1:15 model constructed of steel bars using a 3D scanner and an inductive coil. Sensitivity to a broken rail located between two locomotive axles simulated by an opening in this metallic frame was demonstrated. Further investigation and optimization was conducted on a larger, 1:3 scale, physical model and by running mathematical simulations. Special attention was paid to consistency between the finite element and physical model results. The obtained results allowed establishment of a working frequency range, inductive current injection into the rail-wheel-axle loop and measuring the electromagnetic response to a broken rail. The verification and full scale system prototype tests are following the laboratory experiments and mathematical simulations.
Cell entry and exit by periodontal pathogen via recycling pathway (2011)

In the oral cavity, gingival epithelial cell (GEC) layers function as an innate host defense system to prevent intrusion by periodontal bacteria. Nevertheless, Porphyromonas gingivalis, the most well-known periodontal pathogen, can enter GECs and pass through the epithelial barrier into deeper tissues. An intracellular location is considered advantageous for bacteria to escape from immune surveillance by the host as well as antibiotic pressure, leading to intracellular persistence, multiplication, and dissemination to adjacent tissues. P. gingivalis are invaginated by gingival epithelial cells via the endocytic pathway, and some intracellular bacteria are sorted to lytic compartments, including autolysosomes and late endosomes/lysosomes, while a considerable number of the remaining organisms are sorted to Rab11- and RalA-positive recycling endosomes, followed by bacterial exit from the cells. Exited bacteria can re-enter fresh cells. However, dominant negative forms and RNAi-knockdown of Rab11, RalA, and exocyst complex subunits (Sec5, Sec6, and Exo84) significantly disturb the exit of P. gingivalis. These are the first known results to show that the endocytic recycling pathway mediates bacterial exit from infected cells to neighboring cells and may provide important information regarding the exit mechanisms of various invasive pathogens.
PDDG/PM3 and PDDG/MNDO: Improved semiempirical methods (2002)

Abstract Two new semiempirical methods employing a Pairwise Distance Directed Gaussian modification have been developed: PDDG/PM3 and PDDG/MNDO; they are easily implemented in existing software, and yield heats of formation for compounds containing C, H, N, and O atoms with significantly improved accuracy over the standard NDDO schemes, PM5, PM3, AM1, and MNDO. The PDDG/PM3 results for heats of formation also show substantial improvement over density functional theory with large basis sets. The PDDG modifications consist of a single function, which is added to the existing pairwise core repulsion functions within PM3 and MNDO, a reparameterized semiempirical parameter set, and modified computation of the energy of formation of a gaseous atom. The PDDG addition introduces functional group information via pairwise atomic interactions using only atom‐based parameters. For 622 diverse molecules containing C, H, N, and O atoms, mean absolute errors in calculated heats of formation are reduced from 4.4 to 3.2 kcal/mol and from 8.4 to 5.2 kcal/mol using the PDDG modified versions of PM3 and MNDO over the standard versions, respectively. Several specific problems are overcome, including the relative stability of hydrocarbon isomers, and energetics of small rings and molecules containing multiple heteroatoms. The internal consistency of PDDG energies is also significantly improved, enabling more reliable analysis of isomerization energies and trends across series of molecules; PDDG isomerization energies show significant improvement over B3LYP/6‐31G* results. Comparison of heats of formation, ionization potentials, dipole moments, isomer, and conformer energetics, intermolecular interaction energies, activation energies, and molecular geometries from the PDDG techniques is made to experimental data and values from other semiempirical and ab initio methods. © 2002 Wiley Periodicals, Inc. J Comput Chem 23: 1601–1622, 2002
Capsular polysaccharide regulates neutrophil complement receptor interactions with type III group B streptococci (1993)

The capsular polysaccharide of type III group B streptococci contributes substantially to the virulence of this organism. We explored the extent to which capsular polysaccharide influences neutrophil complement receptor interactions by using a poorly encapsulated strain (COH 31r/s), two well-encapsulated strains (M732 and M912), and strains produced from COH 31r/s by transposon mutagenesis that lacked capsule (COH 31-15) or had capsular polysaccharide lacking terminal sialic acid residues (COH 31-21). When tested with normal human serum, each strain had initially high bactericidal indices (85 to 96%). Monoclonal antibody blockade of neutrophil complement receptor 3 (CD11b/CD18) inhibited opsonophagocytosis to a significantly greater extent for the well-encapsulated strain than for the poorly encapsulated, asialo, or unencapsulated mutant strain. The addition of antibody with specificity for capsular polysaccharide reduced the inhibitory effect significantly for the encapsulated but not for the mutant strains. Blockade of neutrophil complement receptor 1 (CD35) effected only low-level inhibition. However, simultaneous blockade of complement receptors 1 and 3 augmented the inhibitory effect. When hypogammaglobulinemic serum was used as an antibody-free complement source, the initial bactericidal index was low (30% +/- 15%) for an encapsulated strain and was not affected for the mutant strains. Blockade of either neutrophil complement receptor 1 or 3 or the combination fully inhibited killing of the encapsulated strain. These results demonstrate that the type III group B streptococcal capsular polysaccharide regulates interactions with neutrophil complement receptors. We conclude that efficient phagocytic killing of encapsulated group streptococci in nonimmune serum requires ligation of complement receptors 1 and 3.
Permanent magnet array for the magnetic refrigerator (2002)

Recent research into the development of magnetic refrigeration (MR) operating at room temperature has shown that it can provide a reliable, energy-efficient cooling system. To enhance the cooling power of the magnetic refrigerator, it is required to use a magnetic refrigerant material with large magnetocaloric effect (MCE) at the appropriate temperature. Most advanced magnetic refrigerant materials show largest MCE at high applied magnetic fields generated by a superconducting magnet. For application of MCE to air conditioners or household refrigerators, it is essential to develop a permanent magnet array to form a compact, strong, and energy-efficient magnetic field generator. Generating a magnetic field well above the remanence of a permanent magnet material is hard to achieve through conventional designs. A permanent magnet array based on a hollow cylindrical flux source is found to provide an appropriate geometry and magnetic field strength for MR applications.
On Symbol Mapping for Binary Physical-Layer Network Coding with PSK Modulation (2011)

In a system employing physical-layer network coding, the superimposed constellation at the relay may have ambiguity where one received signal is associated with more than one possible combination of users' data. We find the necessary and sufficient condition on a user bit mapping which removes this ambiguity for phase shift keying modulation. Further, we introduce the concept of semi-Gray mapping which improves the system BER performance and achievable rate. The necessary and sufficient condition of having a semi-Gray mapping is also found. Interestingly, the widely used binary reflected Gray mapping does not satisfy the semi-Gray mapping condition resulting in a poorer performance compared to our proposed semi-Gray scheme.
CHROMOSOME NUMBERS OF POINSETTIA (1960)

CHROMOSOME NUMBERS OF POINSETTIA: Euphorbia pulcherrima Klotzsch Get access L. C. EWART, L. C. EWART Search for other works by this author on: Oxford Academic PubMed Google Scholar D. E. WALKER D. E. WALKER *Graduate Assistant and Associate Professor of Plant Breeding, respectively, Department of Horticulture, Pennsylvania State University. Present address of senior auhor: Joseph Harris Company, Inc., Rochester, New York. Authorized for publication on March 10, 1959, as paper No. 2348 in the Journal Series of the Pennsylvania Agricultural Experiment Station. The cultivar material was donated by Paul Ecke Inc., Encinitas, California. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 51, Issue 5, September-October 1960, Pages 203–208, https://doi.org/10.1093/oxfordjournals.jhered.a106989 Published: 01 September 1960
Quantitative measurements of soft tissue structures using image-features in navigated endoscopy (2016)

Below we present a new method to obtain quantitative measurements in medical images of a tracked video endoscope. Such quantitative measurements can be critical biomarkers during endoscopic diagnosis, e.g. for the classification of tumors and polyps. Size-based classifications are often achieved by mere visual estimation which can be imprecise and subjective. To this day established systems of quantitative size measurement are restricted to specific anatomical structures and require additional tools next to the endoscope. We present a system of quantitative measurement during an endoscopic procedure based on a virtual model by utilizing methods from computer vision as well as structure from motion and combining those with an optical tracking system in a novel way. Our experiments show that quantitative measurements of anatomic structures can be reliably attained by our system with an accuracy which exceeds the reported accuracy of visual estimation.