gebhart/patrepeval huggingface dataset:
Prognostic value of immunohistochemical expression of p53, bax, Bcl‐2 and Bcl‐x<sub>L</sub> in resected non‐small‐cell lung cancers (2004)

This study confirms a relevant role for apoptosis-regulatory proteins in the pathogenesis of lung cancer, and highlights the possible role of Bcl-2 as a prognostic factor for this tumour.
Reduction of 1/f Noise by Switched Biasing: An Overview (2005)

MOSFETs are notorious for having strong low frequency noise (1/f noise or flicker noise). In the late 90's we discovered that this noise can be reduced if you periodically switch the bias on and off. This lead to a STW research project "Reduction of 1/f Noise in MOSFETs by Switched Bias Techniques" (TEL.4756), in which we tried to model the effect of large signal excitation on LF noise and explore its application perspective. This paper gives an overview of the main results obtained during this project. We found that the reduction of LF noise is related to capture and emission of electrons in traps, which renders Random Telegraph Noise (RTS noise). The effect of large signal excitation on LF noise can be modeled by making capture and emission time-constants dependent on the instantaneous bias voltage. We were able to show that the energy distribution of traps in the band-gap determines whether there will be significant noise reduction or not.
Identification of the genes encoding the IgM‐α and Ig‐β components of the IgM antigen receptor complex by amino‐terminal sequencing (1990)

Beside the immunoglobulin (Ig) heavy and light chains the murine B cell receptor of the IgM class contains a heterodimer of two transmembrane proteins (IgM-alpha and Ig-beta). By N-terminal sequencing of IgM-alpha and Ig-beta we have identified the genes encoding these proteins as mb-1 and B29, respectively. Both genes are B cell specific and have been previously cloned from B minus T cell subtractive cDNA libraries. We have constructed expression vectors of the two genes and demonstrate that expression of the mb-1 and B29 genes can influence the surface expression of IgM in micron-transfected myeloma cells. From the known sequences of the IgM-alpha and Ig-beta proteins and from the results of previous transfection experiments with various vectors expressing the mu chain we have developed a structural model of the B cell antigen receptor of class IgM which we compare with that of the T cell antigen receptor.
Optimizing parking prices using an agent based approach (2012)

Many cities around the globe are haunted by limited supply of parking and inefficient fee schedules, which often result in additional traffic by people cruising for parking.Pricing parking in an optimal way both from the municipality's and user's perspective in order to balance demand and supply is essential to solve this problem.We propose an agent-based approach to iteratively find such an optimal parking price.A major innovation of our parking model is, that it takes taste heterogeneity of drivers into account.By applying the model to a test scenario in the city of Zurich, we successfully demonstrate, that the model provides key figures, which are essential for supporting decision of policy makers.The paper also discusses some future work, e.g.other applications of the model in the area of parking choice and parking search modeling.
System of Systems - A Holistic Approach for Telemedicine (2011)

New pressure factors are threatening the sustainability of the modern health systems. According to the European Commission assessments A second major aspect is the population ageing -a phenomena which is affecting the developed countries. All those issues, catalyzed by the rapid development of new technologies into the fields of communication, micro and nano technologies, powerful computing capabilities at affordable prices etc. are revolutionizing the way of predict, prevent and treat illness and have triggered a major development of the telemedicine. This paper presents the developments on the telemedicine technology undertaken by UTI Group in partnership with the Faculty of Automatics and Computer Science from the "Politehnica" University of Bucharest, Romania. The partnership aim is to develop solutions to improve the access, efficiency, effectiveness, and quality of clinical and business processes utilized by healthcare and social care organizations, practitioners, patients, and consumers in an effort to improve the health status of patients. This paper is focused on the distributed system architecture, telemedicine system of system (SoS) emergent behavior and describes the main aspects of the distributed telemedicine systems efficiency evaluation.
Partial Improvement of Crystal Quality for Microgravity-Grown Apocrustacyanin C<sub>1</sub> (1997)

The protein apocrustacyanin C(1) has been crystallized by vapour diffusion in both microgravity (the NASA space shuttle USML-2 mission) and on the ground. Rocking width measurements were made on the crystals at the ESRF Swiss-Norwegian beamline using a high-resolution psi-circle diffractometer from the University of Karlsruhe. Crystal perfection was then evaluated, from comparison of the reflection rocking curves from a total of five crystals (three grown in microgravity and two earth controls), and by plotting mosaicity versus reflection signal/noise. Comparison was then made with previous measurements of almost 'perfect' lysozyme crystals grown aboard IML-2 and Spacehab-I and reported by Snell et al. [Snell, Weisgerber, Helliwell, Weckert, Hölzer & Schroer (1995). Acta Cryst. D51, 1099-1102]. Overall, the best diffraction-quality apocrustacyanin C(1) crystal was microgravity grown, but one earth-grown crystal was as good as one of the other microgravity-grown crystals. The remaining two crystals (one from microgravity and one from earth) were poorer than the other three and of fairly equal quality. Crystal movement during growth in microgravity, resulting from the use of vapour-diffusion geometry, may be the cause of not realising the 'theoretical' limit of perfect protein crystal quality.
TIMELY: Improving Labeling Consistency in Medical Imaging for Cell Type Classification (2020)

Diagnosing diseases such as leukemia or anemia requires reliable counts of blood cells. Hematologists usually label and count microscopy images of blood cells manually. In many cases, however, cells in different maturity states are difficult to distinguish, and in combination with image noise and subjectivity, humans are prone to make labeling mistakes. This results in labels that are often not reproducible, which can directly affect the diagnoses. We introduce TIMELY, a probabilistic model that combines pseudotime inference methods with inhomogeneous hidden Markov trees, which addresses this challenge of label inconsistency. We show first on simulation data that TIMELY is able to identify and correct wrong labels with higher precision and recall than baseline methods for labeling correction. We then apply our method to two real-world datasets of blood cell data and show that TIMELY successfully finds inconsistent labels, thereby improving the quality of human-generated labels.
An introduction to speech and speaker recognition (1990)

Five approaches that can be used to control and simplify the speech recognition task are examined. They entail the use of isolated words, speaker-dependent systems, limited vocabulary size, a tightly constrained grammar, and quiet and controlled environmental conditions. The five components of a speech recognition system are described: a speech capture device, a digital signal processing module, preprocessed signal storage, reference speech patterns, and a pattern-matching algorithm. Current speech recognition systems are reviewed and categorized. Speaker recognition approaches and systems are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Simultaneous reception of both quadratures of 40-Gb/s DQPSK using a simple monolithic demodulator (2005)

We demonstrate a novel device that demodulates both quadratures of the optical differential quadrature phase shift keying (DQPSK) format in a single interferometer. We present simultaneous measurements of both DQPSK quadratures at 42.7-Gb/s.
Expression of ERK signaling inhibitors <i>Dusp6</i>, <i>Dusp7</i>, and <i>Dusp9</i> during mouse ear development (2007)

The levels of fibroblast growth factor (FGF) signaling play important roles in coordinating development of the mouse inner, middle, and outer ears. Extracellular signal-regulated kinases (ERKs) are among the effectors that transduce the FGF signal to the nucleus and other cellular compartments. Attenuation of ERK activity by dephosphorylation is necessary to modulate the magnitude and duration of the FGF signal. Recently, we showed that inactivation of the ERK phosphatase, dual specificity phosphatase 6 (DUSP6), causes partially penetrant postnatal lethality, hearing loss and skeletal malformations. To determine whether other Dusps may function redundantly with Dusp6 during otic development, we surveyed the expression domains of the three ERK-specific DUSP transcripts, Dusp6, Dusp7, and Dusp9, in the embryonic mouse ear. We show that each is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development.
Growth and Characterisation of High Purity Quartz (1982)

Abstract : Quartz crystals have grown which have a purity and crystalline perfection significantly in advance of any quartz that is produced commercially today. The crystals produced were approximately 50 mms x 50 mms in area and were 30 mms thick in the growth direction. The total metal ion concentration was less than 1 ppm, with an aluminium content of less than 0.1 ppm. The crystalline perfection is demonstrated by a dislocation density of < 10 lines per square centimeters. (Author)
Correction of Barrel Distortion in Fisheye Lens Images Using Image-Based Estimation of Distortion Parameters (2019)

Images acquired by a fisheye lens camera contain geometric distortion that results in deformation of the object's shape. To correct the lens distortion, existing methods use prior information, such as calibration patterns or lens design specifications. However, the use of a calibration pattern works only when an input scene is a 2-D plane at a prespecified position. On the other hand, the lens design specifications can be understood only by optical experts. To solve these problems, we present a novel image-based algorithm that corrects the geometric distortion. The proposed algorithm consists of three stages: i) feature detection, ii) distortion parameter estimation, and iii) selection of the optimally corrected image out of multiple corrected candidates. The proposed method can automatically select the optimal amount of correction for a fisheye lens distortion by analyzing characteristics of the distorted image using neither prespecified lens design parameters nor calibration patterns. Furthermore, our method performs not only on-line correction by using facial landmark points, but also off-line correction described in subsection III-C. As a result, the proposed method can be applied to a virtual reality (VR) or augmented reality (AR) camera with two fisheye lenses in a field-of-view (FOV) of 195°, autonomous vehicle vision systems, wide-area visual surveillance systems, and unmanned aerial vehicle (UAV) cameras.
Catabolism of hyaluronan in rabbit skin takes place locally, in lymph nodes and liver (1991)

The catabolism of hyaluronan has been studied by injecting hyaluronan, labelled with 125I-tyramine cellobiose (125I-TC), subcutaneously into the hindpaw of rabbits. Following endocytosis, 125I-TC remains in the cells at the site of uptake, allowing localization of the site of catabolism. At 6 h after subcutaneous injection, 65% of the injected radioactivity was recovered. The skin at the injection site contained 47%, the popliteal gland at the side of injection 10%, and the liver 8% of the injected dose. At 48 h the three organs contained 40% of the injected dose with 17% in the skin, 10% in the lymph node and 13% in the liver. The decline in recovery could be accounted for by urinary excretion of the tracer, implying that some tracer had been released from the cells after endocytosis. Chromatography revealed that over 85% of 125I-TC-hyaluronan in the lymph nodes and liver was of low molecular mass throughout the experiment. In skin, 4% of the injected tracer was recovered with low molecular mass at 6 h, increasing to 12% of injected dose at 24 and 48 h. Thus, a minimum of 12% of the injected tracer was catabolized per 24 h at the skin injection site. If cells in skin are responsible for the subsequent release of tracer, as seen from the decrease in recovery of the injected dose, another 10-15% of the tracer could have been catabolized locally in the skin per day. The major part of the hyaluronan injected in the skin was, however, catabolized by lymphatic removal and subsequent degradation in local lymph nodes and liver.
Hole polarization and slow hole-spin relaxation in an<i>n</i>-doped quantum-well structure (1992)

We present a study of the dependence of the hole-spin relaxation on the electron density in an n-modulation-doped 75-\AA{} GaAs/${\mathrm{Al}}_{\mathit{x}}$${\mathrm{Ga}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$As quantum well by using cw and time-resolved photoluminescence techniques, at low temperature. The electron concentration has been continuously varied from ${10}^{11}$ to ${10}^{12}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}2}$. A slow hole-spin relaxation time has been found (\ensuremath{\approxeq}1 ns). A polarization decrease has also been observed when the in-plane wave vector of the photocreated holes increases. Calculations are presented which qualitatively support the latter experimental findings.
MicroRNAs: new players in IBD (2014)

MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.
Sub-bandgap defect states in polycrystalline hafnium oxide and their suppression by admixture of silicon (2005)

The crystallinity of atomic layer deposition hafnium oxide was found to be thickness dependent, with the thinnest films being amorphous and thick films being at least partially crystalline. Hafnium oxide films fabricated by metalorganic chemical vapor deposition are mostly monoclinic. Formation of hafnium silicate by admixture of 20% Si prevents crystallization. Electronic defects are reflected by an absorption feature 0.2–0.3 eV below the optical bandgap. These defects arise in polycrystalline, but not in amorphous, hafnium-based oxides.
POSTTRANSPLANT ANTIDONOR LYMPHOCYTOTOXIC ANTIBODY PRODUCTION IN RELATION TO GRAFT OUTCOME (1987)

Serial serum samples from 266 recipients of primary renal allografts were monitored posttransplant for the presence of panel reactive lymphocytotoxic antibodies (PRA). The minimum posttransplant follow-up period was 18 months. Patients were classified according to whether or not they produced PRA before and/or after transplantation. The groups were as follows: PRA negative before and after transplant, -/-, 171; PRA positive before and negative after transplant, +/-, 5; PRA positive before and positive after transplant, +/+, 27; PRA negative before and positive after transplant, -/+, 63. Actuarial graft survival at 1 year for each group was 81.3%, 100%, 70.4%, 47.6%, respectively. Fifty-five of the 63 -/+ recipients were retrospectively crossmatched with posttransplant sera against stored donor lymphocytes. Of these, 50 (91%) were posttransplant cross match positive, and 37 (67%) have lost their grafts. In 23 of the 26 cases where an anti-HLA specificity was defined, the antibody was directed against antigens present in the donor but not in the recipient. These results clearly indicate that the production of PRA in recipients of renal transplants is associated with antidonor reactivity and poor graft outcome. The fact that these PRA were often directed against donor HLA antigens emphasizes one of the hazards of mismatching for HLA at transplantation.
Wavelength modification of Al<i>x</i>Ga1−<i>x</i>As quantum well heterostructure lasers by layer interdiffusion (1983)

Data are presented showing that thermal annealing (875–-900 °C) can be used to modify the wavelength of a photopumped, low threshold AlxGa1−xAs quantum well heterostructure (QWH) laser from ∼8200 to ∼7300 Å with a threshold change from 150 to 1700 W/cm2. The energy levels of the annealed single quantum well crystal are approximated by fitting a modified Pöschl–Teller potential to the band-edge profile as modified by layer (Al–Ga) interdiffusion. The layer (Al–Ga) interdiffusion coefficient (at 875 °C) is found to be smaller, by a factor of 3–4, than previously reported. We suggest that this is due to the high quality, i.e., low defect density, of the ultralow threshold QWH crystals of this work.
Methods of Protein Digestive Stability Assay - State of the Art (2012)

The evaluation of protein stability in digestive tract is an important topic in various fields of biomedical sciences. The most straightforward task within it is the evaluation of food quality, as during the food processing the digestibility of a protein could fall dramatically. Another task, tightly connected with the previous one, is the evaluation of protein allergenicity. This parameter is shown to be dependent on protein's digestibility, the less digestible ones having the highest probability to induce immune response. Finally, the task of development of new peptide drugs also requires digestive stability check for per os drug forms that are the most convenient for a patient.
von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib. (1992)

von Willebrand factor (vWF) is a multimeric glycoprotein that mediates the adhesion of platelets to the subendothelium by binding to platelet glycoprotein Ib. For human vWF, this interaction can be induced in vitro by the antibiotic ristocetin or the snake venom protein botrocetin. A missense mutation, Gly-561-->Ser, was identified within the proposed glycoprotein Ib binding domain of vWF in the proband with von Willebrand disease type B, a unique variant characterized by no ristocetin-induced, but normal botrocetin-induced, binding to glycoprotein Ib. The corresponding mutant recombinant protein, rvWF(G561S), formed normal multimers and exhibited the same functional defect as the patient's plasma vWF, confirming that this mutation causes von Willebrand disease type B. These data show that botrocetin and ristocetin cofactor activities of vWF can be dissociated by a point mutation and confirm that these mediators promote vWF binding to platelets by different mechanisms. The normal botrocetin-induced binding and the defective ristocetin-induced binding of rvWF(G561S) suggest that the primary defect in von Willebrand disease type B may be a failure of normal allosteric regulation of the glycoprotein Ib binding function of vWF.
Inhibition by N-(Phosphonacetyl)-l-Aspartate of Aspartate Transcarbamylase Activity and Drug-induced Cell Proliferation in Mice (1974)

Abstract N-(phosphonacetyl)-l-aspartate (PALA), a transition state analogue for aspartate transcarbamylase, is an effective inhibitor of the enzyme in a number of tissues when administered to mice. After a single injection of 1 mg of [3H]PALA (1 µCi per mg), PALA concentrations reach a peak of 1.5 x 10-6 m within 2 hours in spleen, and remain at a constant level of 5 x 10-7 m for at least 72 hours in both spleen and liver. PALA concentrations in jejunum are maintained at 10-7 m for at least 72 hours following a single subcutaneous injection. More than 90% of the tissue radioactivity can be recovered as unchanged PALA. The drug is equally effective when given either orally or by subcutaneous injection. Using the activity of aspartate transcarbamylase as a measure of the effective concentration of PALA in the tissue, a single oral dose of as little as 100 µg gives maximum inhibition of the enzyme. Aspartate transcarbamylase activity is maximally inhibited within 15 min of administration and 72 hours later the enzyme activity in spleen is still substantially inhibited. Addition of 1 x 10-7 m PALA in vitro to an extract of spleen inhibits by 80% the incorporation of radioactivity from CO2 into UMP and CMP; approximately 10-6 m PALA is required to give comparable inhibition of incorporation from carbamyl-P. Mice injected with 1 mg of PALA 1 hour before injection with isoproterenol incorporated [14C]thymidine into the DNA of their submaxillary glands at a rate no greater than that of control animals, whereas incorporation by mice injected with isoproterenol alone was markedly stimulated, indicating that PALA effectively blocks the supply of pyrimidine nucleotides required for DNA synthesis in this instance of drug-stimulated proliferation.
<b>Reaction between Fluorine and Alkali Metal Halides at Elevated Pressure and Temperature</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction between Fluorine and Alkali Metal Halides at Elevated Pressure and TemperatureD. H. Kelly, B. Post, and R. W. MasonCite this: J. Am. Chem. Soc. 1963, 85, 3, 307–308Publication Date (Print):February 1, 1963Publication History Published online1 May 2002Published inissue 1 February 1963https://pubs.acs.org/doi/10.1021/ja00886a013https://doi.org/10.1021/ja00886a013research-articleACS PublicationsRequest reuse permissionsArticle Views83Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Theory and Simulation of Surface Plasmon-Coupled Directional Emission from Fluorophores at Planar Structures (2004)

A theoretical approach to surface plasmon-coupled emission (SPCE) from planar structures is developed. It is used for simulations. The results are compared to experimental findings. The match is almost perfect concerning emission angles. Power relations and decay times are reproduced qualitatively. The theory is based on Fresnel plane wave refraction at planar multilayered structures and the Weyl identity for expressing the dipolar radiation in terms of plane waves. One-dimensional integrals, used for the numerical computations, are derived for the fields, powers, and decay enhancements. This theoretical approach is shown to be well suited for design of SPCE setups and for prediction and explanation of experimental results. It also shows promise for refinement and optimization of SPCE, concerning enhancement of weak fluorophores, and usage of decay times.