gebhart/patrepeval huggingface dataset:
The "Feldplatte" a new semiconductor magnetoresistance device (1966)

With a suitable arrangement of both semiconductor and electrodes, one can make a device of InSb, which exhibits a significant increase of ohmic resistance when placed in a magnetic field. An alloy of InSb is produced with 1.8 percent by weight of NiSb, the latter in the form of parallel arranged needles about 1 μ in diameter. Because of their high electrical conductivity) these needles eliminate the Hall effect and cause a great change of resistance when the material is subjected to a magnetic field. The field plate can be used for measuring fields between 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> G and 100 kG.
Cucurbit[6]uril: Organic Molecular Porous Material with Permanent Porosity, Exceptional Stability, and Acetylene Sorption Properties (2008)

Holely organic solid: Effective packing of the rigid macrocycle cucurbituril through CH⋅⋅⋅O hydrogen-bonding and van der Waals interactions leads to a honeycomb-like structure with unprecedented stability and porosity. It shows extraordinary sorption properties toward gases, particularly acetylene, which are comparable or superior to those of metal–organic frameworks in terms of storage capacity. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z800772_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78 (2008)

Many genes involved in cell cycle control have promoters that bind the heterotrimeric transcription factor NF-Y. Several minor-groove binding drugs have been shown to block interactions of transcription factors with cognate DNA-binding sequences. We showed previously that noncovalent minor-groove binding agents block interactions of NF-Y with the promoter of topoisomerase IIalpha (topo IIalpha). In this study, we investigated the ability of GWL-78, a pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugate, to inhibit the binding of NF-Y to DNA. Electrophoretic mobility shift assays showed that GWL-78 could displace NF-Y bound to several CCAAT motifs within promoters of genes involved in cell cycle progression. DNase I footprinting of the topo IIalpha promoter confirmed binding of GWL-78 to AT-rich sequences corresponding to the preferred binding site of NF-Y. Incubation with GWL-78 resulted in displacement of NF-Y binding to DNA. Chromatin immunoprecipitation assays on the topo IIalpha promoter showed that GWL-78 was able to enter the nucleus and interact with specific DNA sequences. Treatment of NIH3T3 cells with GWL-78 resulted in a block of cell cycle progression, which did not involve activation of p53. Thus, agents such as GWL-78 may be useful in modulating transcription and blocking cellular proliferation.
On weakly symmetric structures on a Riemannian manifold (2003)

This is a survey article on weakly symmetric structures on a Riemannian manifold. The study of weakly symmetric and weakly projective symmetric Riemannian manifold were initiated by Tamassy and Binh. Later on several authors studied weakly symmetric Riemannian manifold and analogous structures, viz. weakly Ricci symmetric, weakly projective symmetric and weakly conformally symmetric Riemannian manifolds. Here we present a brief survey of results on weakly symmetric structures on a Riemannian manifold and some applications in the theory of Relativity.
From Polarized Pluralism to Moderate Pluralism: Sartori's Model and the Italian Transition (1996)

Novel or unusual magnetism is a subject of considerable interest, particularly in metals and degenerate semiconductors. In such materials the interplay of magnetism, transport and other Fermi liquid properties can lead to fascinating physical behavior. One example is in magnetic semiconductors, where spin polarized currents may be controlled and used. We report density functional calculations predicting magnetism in doped semiconducting β-FeSi₂ and CrSi₂ at relatively low doping levels particularly for n-type. In this case, there is a rapid cross-over to a half-metallic state as a function of doping level. The results are discussed in relation to the electronic structure and other properties of these compounds.
Tumor Necrosis Factor: How to Make a Killer Molecule Tumor-Specific? (2005)

The interest in TNF, discovered at the interface between inflammation and cancer, as an anti-cancer agent, has phased out in recent years. Indeed, despite its profound cytostatic and cytotoxic effects in primary tumors, the cytokine's systemic toxicity in general and its hepatotoxic and pro-metastatic nature in particular, prevent its routine use in cancer patients. An elegant approach to circumvent these problems consists in the local application of TNF in an isolated limb or organ setting, preferentially in the presence of cytostatic and alkylating agents, such as melphalan. However, this treatment, when locally applied during the perfusion of liver tumors, results in hepatotoxicity in a significant number of the patients, by means of a still unknown mechanism. The hemorrhagic necrosis of the tumors induced by TNF seems to be predominantly mediated by an induction of apoptosis as well as by an anti-angiogenic effect in the endothelial cells of the microvasculature supplying the tumor. These cells therefore represent a prime target for the action of anti-cancer drugs. In this review, we discuss preclinical studies which elucidated the mechanism of melphalan- and TNF-associated hepatotoxicity and, as a consequence, provided insights for preventing the adverse reactions of the drug. Moreover, we review recent findings aimed at improving the TNF molecule by means of specific mutations, or searching for alternative factors lacking the systemic toxicity of TNF.
Design of Two-Terminal Balancing Networks (1943)

This paper describes a simple graphical method for designing a two-terminal network, which will simulate a given line impedance to such a degree that return losses of the order of 25 db or better will be readily obtained. The method is particularly useful in those problems in which a reasonably accurate balancing network is adequate, but a high degree of precision is not required.
[Protracted (lasting) presence of Japanese cedar pollen allergen (Cry j I) in house dust]. (1994)

We investigated the relationship between the amounts of Cry j I in house dust and airborne Cryptomeria japonica pollen in the same location. Cry j I was still detected in house dust collected two weeks after airborne C. japonica pollen had disappeared. Disappearance of Cry j I in house dust coincided with the disappearance of symptoms in the C. japonica pollinosis patients who lived in the same area. Airborne Cupressaceae pollen appeared during the latter half of the C. japonica pollen season. Disappearance of Cupressaceae pollen did not coincided with the disappearance of the symptoms in C. japonica pollinosis patients. Therefore, some symptoms of C. japonica pollinosis patients after C. japonica pollen disappeared from the air may be caused by pollen which had attached to clothes and been brought indoors.
Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation (2016)

Membrane-disrupting antimicrobial peptides provide broad-spectrum defence against localized bacterial invasion in a range of hosts including humans. The most generally held consensus is that targeting to pathogens is based on interactions with the head groups of membrane lipids. Here we show that the action of LL-37, a human antimicrobial peptide switches the mode of action based on the structure of the alkyl chains, and not the head groups of the membrane forming lipids. We demonstrate that LL-37 exhibits two distinct interaction pathways: pore formation in bilayers of unsaturated phospholipids and membrane modulation with saturated phospholipids. Uniquely, the membrane modulation yields helical-rich fibrous peptide-lipid superstructures. Our results point at alternative design strategies for peptide antimicrobials.
High numbers of Shiga toxin-producing<i>Escherichia coli</i>found in bovine faeces collected at slaughter in Japan (2004)

The prevalence and concentration of Shiga toxin-producing Escherichia coli (STEC) in cattle faeces (n= 605) at the time of slaughter was studied in Shimane Prefecture, Japan on a monthly basis between April 2000 and March 2001. Screening with stx-PCR determined a prevalence of 37.5%. After analysis of spread faeces and enriched samples on cefixime, tellurite and sorbitol-MacConkey agar using HCl treatment, 114 STEC strains were singly or concomitantly isolated from 97 cattle (15.9%). Of the 605 cattle, 31 (5.1%) harbored O26:H11, O111:H-, O121:H19 or O157:H7, which had the stx1 and/or stx2 and eae and hlyA genes, and 7 (23%) of these 31 cattle were high level carriers that contained these typical STEC at concentrations of 105-108 CFU/g of faeces. The predominant serotype was O26:H11 (20 strains) and the second most frequent was O157:H7 (9 strains). Of the 605 cattle, 68 (11.2%) harboured 36 other serotypes and 6 (5.9%) of the 67 cattle were high level carriers. As a comparison between the prevalence of STEC and the faecal pH, it was demonstrated that STEC can be isolated from cattle with a wide range of faecal pH values. The presence of a high-carriage animal at the abattoir increases the potential risk of meat contamination during the slaughtering process, regardless of faecal pH.
A cryptographic chip for ISDN and high speed multi-media applications (2002)

The design of a high-speed cryptographic coprocessor is presented. This coprocessor is named Subterranean and can be used for both cryptographic pseudorandom sequence generation (Substream) and cryptographic hashing (Subhash). In Substream mode the chip can be used for stream encryption/decryption under control of a 256-bit key. A cryptographic resynchronization mechanism is provided for fast accessibility encrypted data by legitimate parties. Application fields include the real-time encryption of digital HDTV signals as well as high speed telecommunication and networking such as ATM. The chip has been fabricated within the INVOMEC/EUROCHIP educational VLSI Design Facilities in MIETEC 2.4/spl mu/ CMOS technology. Measured samples are operating at encryption/decryption rates of 286 Mbits/sec and hashing rates of 572 Mbits/sec. The operation of the chip is demonstrated by setup showing the real-time encryption and decryption of digitized PAL color composite video signals. The designed cryptographic module can be used as a stand-alone device or embedded as a mega-block in a larger chip.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A virtual machine for energy management in WSNs (2009)

The paper suggests an operating system-based framework that provides a comprehensive approach for energy management in wireless sensor networks (WSNs). Differently from what proposed in the related literature, the suggested mechanisms decouple the logic behind energy management policies from their implementation. This novel approach allows WSN-users for easily developing their own management policy guaranteeing at the same time independency from the specific network topology, the application running on nodes and the hardware platform.
A Compact X-ray Generator Using a Nanostructured Field Emission Cathode and a Microstructured Transmission Anode (2013)

We report the design, fabrication, and preliminary characterization of a compact X-ray generator for improved X-ray absorption imaging that uses a nanostructured field emission cathode (FEC) as the electron source and a microstructured transmission anode as the X-ray generating element. FECs consume less power, respond faster, and tolerate lower vacuum than thermionic cathodes used in conventional X-ray generators. The use of a transmission anode, instead of a conventional reflection anode, allows filtering of the background radiation (brems strahlung) while allowing efficient generation of X-rays at lower voltages by exciting atomic shell transitions, resulting in emission of X-rays with narrow spectral linewidth for sharper imaging of biological tissue. The fabricated FEC contains arrays of self-aligned, gated field emitters that turn on at bias voltages under 30 V and transmit 99.5% of the electrons to the anode. The FEC emits a maximum current of 1.2 μA per field emitter (588 μA total array current) at a bias voltage of 85 V. A facility is built and tested to generate X-rays with an FEC and a transmission anode. Using the facility, we obtained an X-ray absorption image of an ex-vivos ample that clearly shows softtissue and fine bone structures.
Experimental Study of Severe Slugging in a Two-Phase-Flow Pipeline - Riser Pipe System (1980)

Abstract Slug flow was studied in a simulated, offshore, pipeline-riser pipe system. Two distinct slug flow patterns were identified: severe slugging and normal slug flow. Severe slugging, characterized by generation of slugs ranging in length from one to several riser pipe heights, occurs at low gas and liquid flow rates and for negative pipeline inclinations. A mathematical model was developed for severe slugging. Results agree well with experimental data. Choking was found to be an effective method of eliminating severe slugging.
Structural Requirements for the Binding of tRNA3Lys to Reverse Transcriptase of the Human Immunodeficiency Virus Type 1 (1995)

Reverse transcription of the human immunodeficiency virus type 1 (HIV-1) RNA genome is primed by the cellular tRNA Lys3 molecule. Packaging of this tRNA primer during virion assembly is thought to be mediated by specific interactions with the reverse transcriptase (RT) protein. Portions of the tRNA molecule that are required for interaction with the RT protein remain poorly defined. We have used an RNA gel mobility shift assay to measure the in vitro binding of purified RT to mutant forms of tRNA Lys3. The anticodon loop could be mutated without eliminating RT recognition. However, mutations in the T psi C stem were found to partially interfere with RT binding, and D arm mutants were completely inactive in RT binding. Interestingly, binding of the RT protein to tRNA Lys3 facilitates the subsequent annealing of template strand to the 3'-terminus of the tRNA molecule. Consistent with this finding, we demonstrate that mutant HIV-1 virions lacking the RT protein do contain a viral RNA genome without an associated tRNA Lys3 primer. We also found that a preformed primer tRNA-template complex is efficiently recognized by RT protein in vitro. Extension of the template molecule over the T psi C loop did result in complete inhibition of RT binding, suggesting the presence of additional recognition elements in the T psi C loop. These results, combined with a comparative sequence analysis of tRNA species present in HIV-1 virions and RNA motifs selected in vitro for high affinity RT binding, suggest that RT recognizes the central domain of the tRNA tertiary structure, which is formed by interaction of the D and T psi C loops.
Aptamers That Preferentially Bind Type IVB Pili and Inhibit Human Monocytic-Cell Invasion by <i>Salmonella enterica</i> Serovar Typhi (2005)

Salmonella enterica serovar Typhi is an important pathogen exclusively for humans and causes typhoid or enteric fever. It has been shown that type IVB pili, encoded by the S. enterica serovar Typhi pil operon located in Salmonella pathogenicity island 7, are important in the pathogenic process. In this study, by using both an adhesion-invasion assay and fluorescence quantitative PCR analysis, we demonstrated that the entry of type IVB piliated S. enterica serovar Typhi A21-6 (pil(+) Km(r)) into human THP-1 monocytic cells was greater than that of a nonpiliated S. enterica serovar Typhi pilS::Km(r) (pil mutant) strain. We have applied a systematic evolution of ligands by exponential enrichment approach to select oligonucleotides (aptamers) as ligands that specifically bind to type IVB pili. Using this approach, we identified a high-affinity single-stranded RNA aptamer (S-PS(8.4)) as a type IVB pilus-specific ligand and further found that the selected aptamer (S-PS(8.4)) could significantly inhibit the entry of the piliated strain (but not that of the nonpiliated strain) into human THP-1 cells. The binding affinities between aptamers and pre-PilS (structural protein of type IVB pili) were determined by nitrocellulose filter-binding assays, and the K(d) value was determined to be 8.56 nM for the S-PS(8.4) aptamer alone. As an example of an aptamer against type IVB pili of S. enterica serovar Typhi, the aptamer S-PS(8.4) can serve as a tool for analysis of bacterial type IVB pilus-host cell interactions and may yield information for the development of putative new drugs against S. enterica serovar Typhi bacterial infections, useful both in prevention of infection and in therapeutic treatment.
Laser-driven Sisyphus cooling in an optical dipole trap (2011)

We propose a laser-driven Sisyphus-cooling scheme for atoms confined in a far-off resonance optical dipole trap. Utilizing the differential trap-induced ac Stark shift, two electronic levels of the atom are resonantly coupled by a cooling laser preferentially near the trap bottom. After absorption of a cooling photon, the atom loses energy by climbing the steeper potential, and then spontaneously decays preferentially away from the trap bottom. The proposed method is particularly suited to cooling alkaline-earth-metal-like atoms where two-level systems with narrow electronic transitions are present. Numerical simulations for the cases of ${}^{88}$Sr and ${}^{174}$Yb demonstrate the expected recoil and Doppler temperature limits. The method requires a relatively small number of scattered photons and can potentially lead to phase-space densities approaching quantum degeneracy in subsecond time scales.
Time-Voltage QRS Area of the 12-Lead Electrocardiogram (1998)

Identification of left ventricular hypertrophy (LVH) using 12-lead ECG criteria based primarily on QRS amplitudes has been limited by poor sensitivity at acceptable levels of specificity. Because the product of QRS voltage and duration, as an approximation of the time-voltage area of the QRS complex, can improve accuracy of the 12-lead ECG for LVH, we examined the diagnostic value of true time-voltage area measurements of QRS complexes from the standard 12-lead ECG. Standard 12-lead ECGs and echocardiograms were obtained in 175 control subjects without LVH and in 74 patients with regurgitant valvular heart disease and LVH defined by echocardiographic criteria (indexed LV mass >110 g/m2 in women and >125 g/m2 in men). Standard voltage criteria, voltage-duration products (voltage multiplied by QRS duration), and true time-voltage areas of the QRS were calculated for Sokolow-Lyon criteria (SV1 +RV(5/6)) and the 12-lead sum of voltage criteria. Test sensitivities were compared using gender-specific partitions with matched specificity of 98% in the 175 subjects without LVH. Measurement of the time-voltage area significantly improved sensitivity for both criteria. The 76% sensitivity of the 12-lead sum area and 65% sensitivity of Sokolow-Lyon area were significantly greater than the 54% sensitivity of the approximation of QRS area provided by each voltage-duration product (P<.001 and P=.021) and than the 46% and 43% sensitivities of the respective simple voltage criteria (each P<.001). Comparison of receiver operating characteristic curves confirmed the superior overall performance of time-voltage area criteria compared with both voltage-duration products and simple voltage criteria. These results suggest that use of time-voltage areas can dramatically improve identification of LVH by 12-lead ECG. Further study of this approach is needed to identify optimal criteria for LVH based on the time-voltage area measurements from the 12-lead ECG.
Eicosanoid synthesis by cultured human urothelial cells: potential role in bladder cancer. (1986)

Prostaglandin (PG) H synthase and eicosanoid products of arachidonic acid metabolism have been implicated in several steps in the carcinogenic process. This study assessed these parameters using primary cultures of human urothelial cells. To determine the possible presence of permeability barriers to agonist stimulation, incubations were performed with adherent cells in the presence or absence of thioglycolate pretreatment or with cell suspensions. No evidence for permeability barriers was observed. With adherent cells in the absence of thioglycolate, radioimmunoassayable PGE2 was stimulated by epinephrine less than 12-O-tetradecanoylphorbol-13-acetate = thrombin less than bradykinin = A23187 much less than arachidonic acid. Tumor promoters but not non-tumor promoters stimulated PGE2 synthesis. 1-Oleoyl-2-acetylglycerol which like 12-O-tetradecanoylphorbol-13-acetate activates protein kinase C also increased PGE2 synthesis. Cells prelabeled with [14C]arachidonic acid were exposed to agonists and the profile of eicosanoids synthesized was assessed by high performance liquid chromatography. With bradykinin, the pattern of eicosanoids synthesized was 6-keto-PGE1 alpha (12% of total 14C label), thromboxane B2 (0.4%), PGF2 alpha (1.7%), PGE2 (18%), PGD2 (1%), leukotrienes (0.4 to 1%), 12-hydroxy-5,8,10-heptadecatrienoic acid (3%), 15-hydroxy-5,8,11,13-eicosatetraenoic acid (4%), 12-hydroxy-5,8,10,14-eicosatetraenoic acid (0%) and 5-hydroxy-5,8,12,14-eicosatetraenoic acid (2%). Thus, human urothelial cells contain both prostaglandin H synthase and lipoxygenase pathways with the former being more prominent. These pathways may participate in urinary bladder carcinogenesis.
FEASIBILITY OF FULLERENE HYDRIDE AS A HIGH CAPACITY HYDROGEN STORAGE MATERIAL (2001)

The results of recent investigation of fullerenefullerene hydride system as a potential high capacity hydrogen storage option are presented. Theoretically, C60 fullerenes can reversibly store up to 7.7 wt. % hydrogen by forming fullerene hydride C60Hx. However, high temperature and pressure are currently required to enable hydrogen exchange in this system. For example, direct hydrogenation of fullerenes in the presence of gaseous hydrogen at ~450°C and ~ 3 MPa yields fullerene hydride with ~6.1 wt. % hydrogen content. Over the past years, MER has been searching for practical ways to facilitate hydrogen storage on fullerenes at milder conditions. The main focus of the research was concentrated on optimizing catalytic system including transition-metal liquid state catalysts, as well as modifying electronic structure of fullerenes by doping them with electron-donating elements (for example, alkali metals). As a result of this investigation, certain progress was made in lowering the temperature and pressure required for hydrogenation. However, dehydrogenation parameters still remain to be optimized.