gebhart/patrepeval huggingface dataset:
Solution route to inorganic nanobelt‐conducting organic polymer core‐shell nanocomposites (2005)

Abstract A facile and versatile solution‐based approach was developed to prepare semiconductor metal oxide nanobelt‐conducting organic polymer core‐shell nanocomposites. Well‐defined nanobelts of several types of oxide nanobelts were combined with conducting polymer [polypyrrole (PPy) and polyaniline (PANi)] via in situ polymerization in aqueous solution to obtain a new type of inorganic–organic composite nanostructure. Samples were characterized by using X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared, electron energy loss spectra, high‐resolution transmission electron microscopy, and ultraviolet–visible techniques. Electron energy loss spectra revealed the existence of CC and CN bonds in coating layers to prove the encapsulation of PPy or PANi. The red‐shift of absorption band at high‐energy was observed for PPy‐encapsulated composites via ultraviolet–visible spectroscopy, and significant absorption band shifts were also encountered to PANi‐encapsulated composites, which suggest possibilities of band‐gap tuning of such metal oxide‐conducting polymer composites to be applied especially in solar cell devices. However, the sacrifice of nanobelts‐core led to hollow structures of PPy and PANi, which expands the synthetic strategies to prepare conducting polymer nanotubes. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 2892–2900, 2005
Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Expression Is Decreased in Pulmonary Hypertension and Affects Endothelial Cell Growth (2003)

PPARgamma is a member of a family of nuclear receptors/ligand-dependent transcription factors, which bind to hormone response elements on target gene promoters. An antiproliferative and proapoptotic action profile of PPARgamma has been described and PPARgamma may function as a tumor suppressor gene, but little is known about the role of PPARgamma in vascular remodeling. One group of human diseases that shows impressive vascular remodeling exclusively in the lungs is the group of severe pulmonary hypertensive disorders, which is characterized by complex, endothelial cell-proliferative lesions of lung precapillary arterioles composed of clusters of phenotypically altered endothelial cells that occlude the vessel lumen and contribute to the elevation of the pulmonary arterial pressure and reduce local lung tissue blood flow. In the present study, we report the ubiquitous PPARgamma expression in normal lungs, and in contrast, a reduced lung tissue PPARgamma gene and protein expression in the lungs from patients with severe PH and loss of PPARgamma expression in their complex vascular lesions. We show that fluid shear stress reduces PPARgamma expression in ECV304 endothelial cells, that ECV304 cells that stably express dominant-negative PPARgamma (DN-PPARgamma ECV304) form sprouts when placed in matrigel and that DN-PPARgamma ECV304 cells, after tail vein injection in nude mice, form lumen-obliterating lung vascular lesions. We conclude that fluid shear stress decreases the expression of PPARgamma in endothelial cells and that loss of PPARgamma expression characterizes an abnormal, proliferating, apoptosis-resistant endothelial cell phenotype.
Probiotic <scp>VSL</scp>#3‐induced <scp>TGF</scp>‐β ameliorates food allergy inflammation in a mouse model of peanut sensitization through the induction of regulatory <scp>T</scp> cells in the gut mucosa (2013)

TGF-β, induced in the gut by VSL#3 supplementation, is capable of reducing the Th2 inflammation associated with food anaphylaxis in a mouse model of peanut sensitization. TGF-β acts through the induction/maintenance of regulatory T cells expressing FOXP3 and/or latency-associated peptide. Probiotics supplementation may represent an effective and safe strategy for treating food allergies in adult population.
Assessment of megabase-scale somatic copy number variation using single-cell sequencing (2016)

Megabase-scale copy number variants (CNVs) can have profound phenotypic consequences. Germline CNVs of this magnitude are associated with disease and experience negative selection. However, it is unknown whether organismal function requires that every cell maintain a balanced genome. It is possible that large somatic CNVs are tolerated or even positively selected. Single-cell sequencing is a useful tool for assessing somatic genomic heterogeneity, but its performance in CNV detection has not been rigorously tested. Here, we develop an approach that allows for reliable detection of megabase-scale CNVs in single somatic cells. We discover large CNVs in 8%-9% of cells across tissues and identify two recurrent CNVs. We conclude that large CNVs can be tolerated in subpopulations of cells, and particular CNVs are relatively prevalent within and across individuals.
Der Mensch und Forscher J. Ch. FABRICIUS (1967)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Investigation of the Cross-Ratios Method for Point-of-Gaze Estimation (2008)

The cross-ratios method for point-of-gaze (PoG) estimation uses the invariance property of cross-ratios in projective transformations. The inherent causes of the subject-dependent PoG estimation bias exhibited by this method have not been well characterized in the literature. Using a model of the eye and the components of a system (camera, light sources) that estimates PoG, a theoretical framework for the cross-ratios method is developed. The analysis of the cross-ratios method within this framework shows that the subject-dependent estimation bias is caused mainly by: 1) the angular deviation of the visual axis from the optic axis and 2) the fact that the virtual image of the pupil center is not coplanar with the virtual images of the light sources that illuminate the eye (corneal reflections). The theoretical framework provides a closed-form analytical expression that predicts the estimation bias as a function of subject-specific eye parameters. The theoretical framework also provides a clear physical interpretation for an existing empirically derived two-step procedure that compensates for the estimation bias and shows that the first step of this procedure is equivalent to moving the corneal reflections to a new plane that minimizes the distance from this plane to the virtual image of the pupil center.
Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells. (1991)

ras oncogene-transformed NIH 3T3 cells expressing glucocorticoid-inducible antisense c-myc cDNA transcripts at levels sufficient to deplete c-myc protein lost their transformed morphology and the ability to grow in soft agar; their ability to form tumors in nude mice was also impaired. These changes were dependent on the continuous expression of the antisense sequences. No major effects on plating efficiencies, growth rates in monolayer culture, or immortalization were observed in the revertant cells, indicating that the observed effects were not a toxic consequence of c-myc protein depletion. Transfection with the same vector expressing c-myc in the sense orientation or other control vectors had no effect on transformation. These results suggest that a certain minimum level of expression of c-myc is required for the maintenance of ras transformation in NIH 3T3 cells.
Spatio-Temporal Sensor Graphs (STSG): A data model for the discovery of spatio-temporal patterns1 (2009)

Developing a model that facilitates the representation and knowledge discovery on sensor data presents many challenges. With sensors reporting data at a very high frequency, resulting in large volumes of data, there is a need for a model that is memo
Protecting CRT RSA against Fault and Power Side Channel Attacks (2012)

The RSA cryptographic algorithm is a security tool that has achieved long cryptographic and market maturity. However, after the discovery and wide spread of Side Channel Attacks (SCA), RSA implementations are susceptible to a variety of different attacks that target the hardware structure rather than the algorithm itself. While there are a wide range of countermeasures that can be applied on the RSA structure in order to protect the algorithm from specific SCA categories, combining several such measures to produce an "all in one" SCA resistant RSA structure is not an easy endeavor. Several incompatibility issues between combined SCA protection methods lead to new SCA vulnerabilities. In this paper, we evaluate some very popular and potent SCAs against RSA, like Fault attacks (FA), Simple Power attacks (SPA), Doubling attacks (DA) and Differential Power attacks (DPA), and propose an SCA protection scheme for RSA based on Chinese Remainder Theorem (CRT) that can thwart them. The proposed scheme uses a square and always multiply approach in combination with the message blinding technique in such a way that possible vulnerabilities that may rise from this combination can no longer apply. The proposed scheme is evaluated against specific SCAs and is found to be very secure. From performance point of view, the proposed scheme favors parallelism and can calculate an RSA result with small time delay.
Approximate Planning in POMDPs with Macro-Actions (2003)

Recent research has demonstrated that useful POMDP solutions do not require consideration of the entire belief space. We extend this idea with the notion of temporal abstraction. We present and explore a new reinforcement learning algorithm over grid-points in belief space, which uses macro-actions and Monte Carlo updates of the Q-values. We apply the algorithm to a large scale robot navigation task and demonstrate that with temporal abstraction we can consider an even smaller part of the belief space, we can learn POMDP policies faster, and we can do information gathering more efficiently. 1
Robocentric mapping and localization in modified spherical coordinates with bearing measurements (2009)

In this paper, a new approach to robotic mapping is presented that uses modified spherical coordinates in a robot-centered reference frame and a bearing-only measurement model. The algorithm provided in this paper permits robust delay-free state initialization and is computationally more efficient than the current standard in bearing-only (delay-free initialized) simultaneous localization and mapping (SLAM). Importantly, we provide a detailed nonlinear observability analysis which shows the system is generally observable. We also analyze the error convergence of the filter using stochastic stability analysis. We provide an explicit bound on the asymptotic mean state estimation error. A comparison of the performance of this filter is also made against a standard world-centric SLAM algorithm in a simulated environment.
Calcium and Calpain as Key Mediators of Apoptosis-like Death Induced by Vitamin D Compounds in Breast Cancer Cells (2002)

The active form of vitamin D(3) (1,25(OH)(2)D(3)) induces an increase in the intracellular free calcium ([Ca(2+)](i)) and caspase-independent cell death in human breast cancer cells. Here we show that the treatment of MCF-7 breast cancer cells with 1,25(OH)(2)D(3) or its chemotherapeutic analog, EB 1089, releases Ca(2+) from the endoplasmic reticulum. The increase in [Ca(2+)](i) was associated with the activation of a calcium-dependent cysteine protease, mu-calpain. Interestingly, ectopic expression of a calcium-binding protein, calbindin-D(28k), in MCF-7 cells not only attenuated the elevation in [Ca(2+)](i) and calpain activation, but also reduced death triggered by vitamin D compounds. Similarly, the inhibition of calpain activity by structurally unrelated chemical inhibitors increased the survival of the cells and reduces the amount of annexin V-positive cells. Despite the complete absence of effector caspase activation, transmission electron microscopy of MCF-7 cells treated with 1,25(OH)(2)D(3) or EB 1089 revealed apoptosis-like morphology characterized by the condensed cytoplasm, nuclei, and chromatin. Overall, these results suggest that calpain may take over the role of the major execution protease in apoptosis-like death induced by vitamin D compounds. Thus, these compounds may prove useful in the treatment of tumors resistant to therapeutic agents dependent on the classical caspase cascade.
Microearthquake location: A nonlinear approach that makes use of a simplex stepping procedure (1988)

Abstract We present an earthquake location scheme that uses the simplex algorithm in the solution. This method of direct iteration is conceptually simple, does not require derivative calculations, and avoids matrix inversions. The algorithm can be programmed on a small computer and its performance compares favorably with other methods of earthquake location. The method can be used for any velocity structure for which source to geophone times can be calculated. We use a horizontally layered velocity model, and consider both critically and noncritically refracted rays. It is easy to incorporate any time residual misfit norm into the location calculation. We generally use the L1 or L2 (least-squares) norm. The routine we present is used in two different microseismic monitoring systems at two potash mines in Saskatchewan, Canada.
Mode controlled guided wave tomography using annular array transducers for SHM of water loaded plate like structures (2013)

Ultrasonic guided wave tomography utilizes an array of permanently mounted transducers to detect and image defects like corrosion, cracks and delamination in structures. It is critical for successful tomography imaging to avoid the influences from external environmental conditions like water loading and changes in temperature. Water loading is particularly challenging as it affects the guided wave propagation in the structure. However, by taking advantage of the physical properties of guided waves it is possible to reduce its effect on the tomography images. Modal points on the dispersion curves can be found that have low out-of-plane displacement in their wave structure and hence no leakage into the liquid on the structure. In this paper, the omnidirectional excitation of desired guided wave modes with annular array transducers is discussed. Guided wave tomography of a steel plate like structure with a corrosion defect is studied under water loading conditions. The influence of water loading is overcome by exciting symmetric guided wave modes (S1) in the structure. Utilizing guided wave mode control it is shown that the defects in the structure can be easily discriminated from any artifacts in the images due to the liquid layer.
Adapting Neural Text Classification for Improved Software Categorization (2018)

Software Categorization is the task of organizing software into groups that broadly describe the behavior of the software, such as "editors" or "science." Categorization plays an important role in several maintenance tasks, such as repository navigation and feature elicitation. Current approaches attempt to cast the problem as text classification, to make use of the rich body of literature from the NLP domain. However, as we will this paper, algorithms are generally not applicable off-the-shelf to source code; we found that they work well when high-level project descriptions are available, but suffer very large performance penalties when classifying sourcecode and comments only. We propose a set of adaptations to a state-of-the-art neural classification algorithm and perform two evaluations: one with reference data from Debian end-user programs, and one with a set of C/C++ libraries that we hired professional programmers to annotate. We show that our proposed approach achieves performance exceeding that of previous software classification techniques as well as a state-of-the-art neural text classification technique.
Web content adaptation for mobile device: A fuzzy-based approach (2012)

While HTML will continue to be used to develop Web content, how to effectively and efficiently transform HTML-based content automatically into formats suitable for mobile devices remains a challenge. In this paper, we introduce a concept of coherence set and propose an algorithm to automatically identify and detect coherence sets based on quantified similarity between adjacent presentation groups. Experimental results demonstrate that our method enhances Web content analysis and adaptation on the mobile Internet.
Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Gα13/RhoA-mediated Migration (2018)

G-protein-coupled receptor (GPCR) heterodimerization has emerged as a means by which alternative signaling entities can be created; yet, how receptor heterodimers affect receptor pharmacology remains unknown. Previous observations suggested a biochemical antagonism between GPCRs, CXCR4 and CB2 (CNR2), where agonist-bound CXCR4 and agonist-bound CB2 formed a physiologically nonfunctional heterodimer on the membrane of cancer cells, inhibiting their metastatic potential <i>in vitro</i> However, the reduced signaling entities responsible for the observed functional outputs remain elusive. This study now delineates the signaling mechanism whereby heterodimeric association between CXCR4 and CB2, induced by simultaneous agonist treatment, results in decreased CXCR4-mediated cell migration, invasion, and adhesion through inhibition of the Gα13/RhoA signaling axis. Activation of CXCR4 by its cognate ligand, CXCL12, stimulates Gα13 (GNA13), and subsequently, the small GTPase RhoA, which is required for directional cell migration and the metastatic potential of cancer cells. These studies in prostate cancer cells demonstrate decreased protein expression levels of Gα13 and RhoA upon simultaneous CXCR4/CB2 agonist stimulation. Furthermore, the agonist-induced heterodimer abrogated RhoA-mediated cytoskeletal rearrangement resulting in the attenuation of cell migration and invasion of an endothelial cell barrier. Finally, a reduction was observed in the expression of integrin α5 (ITGA5) upon heterodimerization, supported by decreased cell adhesion to extracellular matrices <i>in vitro</i> Taken together, the data identify a novel pharmacologic mechanism for the modulation of tumor cell migration and invasion in the context of metastatic disease.<b>Implications:</b> This study investigates a signaling mechanism by which GPCR heterodimerization inhibits cancer cell migration. <i>Mol Cancer Res; 16(4); 728-39. ©2018 AACR</i>.
A new write/erase method for the reduction of the stress-induced leakage current based on the deactivation of step tunneling sites for flash memories (2002)

This paper describes a new write/erase method to improve the read disturb characteristics by means of drastically reducing the stress-induced leakage current in the tunnel oxide. With the proposed write/erase method, the degradation of the read disturb life time after 10/sup 6/ write/erase cycles can be drastically reduced to 50% in comparison with the conventional bipolarity write/erase method. The features of the proposed write/erase method are as follows: (1) applying an additional pulse to the control gate just after completion of the write/erase operation; (2) the voltage of the additional pulse is higher than that of the control gate in a read operation, and lower than that of the control gate in a write operation; and (3) the polarity of the voltage is the same as that of the control gate voltage in the read operation. This proposed write/erase method is based on the deactivation mechanism of the leakage current, which is discussed in detail in this paper.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mode coupling in spiral fibre gratings (2001)

The coupling properties of spiral fibre gratings are presented. It is shown that LP01 modes in spiral fibre gratings couple to both LP11 even and odd modes.
Colonialism, Han, and the Transformative Spirit / Grace Ji-Sun Kim (2014)

Grace Ji-Sun Kim is a bold and eloquent writer. In this book, two issues disturb her: colonialism and its legacy, and an eco-system in crisis. Writing from an affluent North-American context, Kim derides a life-style of consumerism, which once through deliberate empire-building exploited the developing world, and now continues to manipulate it through economic means. The prevailing capitalist system, which structures the global political economy, homogenizes our world. A resentment is present both within those who are the victims of these imposed forms of labour, production, consumption, and exchange, and also within a burdened environment. This is han, a person in pain, the earth-soul wounded. Liberation from han is equity, sufficiency, harmony and an eradication of the exploitation of persons and nature.
R- chie : a web server and R package for visualizing RNA secondary structures (2012)

Visually examining RNA structures can greatly aid in understanding their potential functional roles and in evaluating the performance of structure prediction algorithms. As many functional roles of RNA structures can already be studied given the secondary structure of the RNA, various methods have been devised for visualizing RNA secondary structures. Most of these methods depict a given RNA secondary structure as a planar graph consisting of base-paired stems interconnected by roundish loops. In this article, we present an alternative method of depicting RNA secondary structure as arc diagrams. This is well suited for structures that are difficult or impossible to represent as planar stem-loop diagrams. Arc diagrams can intuitively display pseudo-knotted structures, as well as transient and alternative structural features. In addition, they facilitate the comparison of known and predicted RNA secondary structures. An added benefit is that structure information can be displayed in conjunction with a corresponding multiple sequence alignments, thereby highlighting structure and primary sequence conservation and variation. We have implemented the visualization algorithm as a web server R-chie as well as a corresponding R package called R4RNA, which allows users to run the software locally and across a range of common operating systems.