gebhart/patrepeval huggingface dataset:
Analysis of 1,25-Dihydroxyvitamin D<sub>3</sub> Genomic Action Reveals Calcium-Regulating and Calcium-Independent Effects in Mouse Intestine and Human Enteroids (2020)

Although vitamin D is critical for the function of the intestine, most studies have focused on the duodenum. We show that transgenic expression of the vitamin D receptor (VDR) only in the distal intestine of VDR null mice (KO/TG mice) results in the normalization of serum calcium and rescue of rickets. Although it had been suggested that calcium transport in the distal intestine involves a paracellular process, we found that the 1,25-dihydroxyvitamin D<sub>3</sub> [1,25(OH)<sub>2</sub>D<sub>3</sub>]-activated genes in the proximal intestine associated with active calcium transport (<i>Trpv6</i>, <i>S100g</i>, and <i>Atp2b1</i>) are also induced by 1,25(OH)<sub>2</sub>D<sub>3</sub> in the distal intestine of KO/TG mice. In addition, <i>Slc30a10</i>, encoding a manganese efflux transporter, was one of the genes most induced by 1,25(OH)<sub>2</sub>D<sub>3</sub> in both proximal and distal intestine. Both villus and crypt were found to express <i>Vdr</i> and VDR target genes. RNA sequence (RNA-seq) analysis of human enteroids indicated that the effects of 1,25(OH)<sub>2</sub>D<sub>3</sub> observed in mice are conserved in humans. Using <i>Slc30a10</i><sup>-/-</sup> mice, a loss of cortical bone and a marked decrease in <i>S100g</i> and <i>Trpv6</i> in the intestine was observed. Our findings suggest an interrelationship between vitamin D and intestinal Mn efflux and indicate the importance of distal intestinal segments to vitamin D action.
Pro JSF and HTML5: Building Rich Internet Components (2013)

Pro JSF and HTML5 shows you how to leverage the full potential of JavaServer Faces (JSF) and HTML5. This book is for Java developers who aspire to build sophisticated, enterprise-grade web experiences with HTML5-enabled JSF. Written by JSF experts and verified by established community figures, this book will serve as your primary resource, helping you build or integrate well-designed HTML5-enabled JSF components into your rich internet applications. Pro JSF and HTML5 starts by giving you a firm grounding in the design principles of component-based frameworks and the basics of JSF. It then details recent advancements in JSF 2.2 that make it friendlier, faster, and more productive than ever before. And it covers HTML5-enabled components, integration with JEE7 standards, 3rd party component libraries, security, and performance. The book concludes with a real-world application that puts everything you learned into practice. In this book youâll learn Foundational JSF topics such as the component life cycle, framework architecture, managed beans and CDI, expression language, conversion and validation, JSF events and view parameters. Leveraging new features in JSF 2.2 such as Faces Flow, Resource Library Contracts, and Ajax file uploading. Developing Advanced HTML5 enabled components in JSF 2.2. Creating JSF 2.2 applications that utilize Java EE 7 technologies (CDI, JPA 2.1 and EJB 3.2) for bean management, transaction management and persistence. Building advanced real-world JSF applications with considerations for security, performance, and usability. If youâre a Java developer interested in the world of component-based frameworks, Pro JSF and HTML5 is for you.
Control of a series-input, parallel-output cell balancing system for electric vehicle battery packs (2015)

Cell balancing circuits are required in battery packs to equalize the state-of-charge (SOC) of series-connected cells. This paper presents a control strategy for a modular cell balancing architecture based on low-voltage bypass dc-dc converters that perform real-time active cell balancing using a shared low-voltage (LV) bus. Each bypass converter includes an autonomous controller, which employs a faster loop with a standard PI compensator to regulate the LV bus voltage and a slower loop with droop control to regulate SOC of each cell. The control strategy results in balanced LV load current sharing among bypass converters. Design and stability analysis details are provided for the cell balancing system and bypass converters. The control approach is verified by experimental results for a three series-connected Li-ion NMC battery cell system with three digitally controlled dual-active bridge bypass converters.
Measurement of Attenuation and Speed of Sound in Soils (2002)

The potential application of this work is the detection and imaging of buried objects using acoustic methodology. To image buried artifacts, it is vital to know speed and attenuation of sound in the particular soil being examined because they vary in different soil types and at different moisture contents. To that end, our research involved six soils representing a range of properties expected to influence acoustic response. Clay ranged from 2 to 38%, silt from 1 to 82%, sand from 2 to 97%, and organic matter from 0.1 to 11.7%. Signals from an acoustic source were passed through soil samples and detected by an acoustically coupled hydrophone. From a total of 231 evaluations, we determined the acoustic attenuation coefficient and the propagation speed of sound in the soil samples as a function of four levels of soil moisture and two levels of compaction. Attenuation coefficients determined over frequencies of 2 to 6 kHz ranged from 0.12 to 0.96 dB cm −1 kHz −1 Lower attenuation tended to be in loose dry samples. Correlation coefficients were 0.35 ( P = 0.01) and 0.31 ( P = 0.03) between attenuation and soil water content and soil bulk density, respectively. Propagation speeds ranged from 86 to 260 m s −1 The correlation coefficient with speed was −0.28 ( P = 0.05) for soil water content and −0.42 ( P = 0.002) for total porosity. Given the acoustic properties, it is theoretically possible to detect an object down to ∼40 cm below the soil surface.
Design and construction of a high-speed high-performance direct-drive handpiece (1987)

The electrical and mechanical design of a precision handpiece (or handtool) delivering 10 W at 150 000 rev/min is described. The 2-pole synchronous drive motor has a samarium-cobalt rotor magnet of axial length 7 mm and diameter 3 mm. The motor has mumetal laminations and a bar winding which is supplied at 2.5 kHz by three toroidal transformers built into the unit. An equivalent circuit and experimental data are given from a prototype constructed according to the design procedure.
Combination of a Time Reversal Process and a Consecutiv Outlier Analysis for Baseline-free Damage Diagnosis (2007)

A structural health monitoring system is developed for continuous online monitoring of delamination initiation and growth in composite structures. Structural health monitoring problems are often cast in the context of a statistical pattern recognition paradigm, in which a damage state of a structure is inferred by comparing test data with baseline data. However, subtle signal changes due to damage can often be masked by larger ambient variation of operational and environmental conditions of an in-service structure. Therefore, it is critical for the development of a robust monitoring system to minimize false-positive indications of damage caused by the undesired operational and environmental variation of the structure. The issue of minimizing damage misclassification has been addressed in this article by developing an instantaneous damage detection scheme that does not rely on past baseline data. The proposed instantaneous damage diagnosis is based on the concepts of time reversal acoustics and consecutive outlier analysis, and the proposed damage diagnosis has been tested for detecting delamination in composite plates.
Type 73 human papillomavirus in esophageal squamous cell carcinoma: A novel association (1996)

Squamous cell carcinoma in situ of the esophagus may be associated with infection by HPV-73.
Gas chromatographic techniques and applications (2001)

Developments in sample preparation for capillary GC analysis Sample injection systems Advances in column technology Detectors for quantitative gas chromatography Detectors for compound identification Method validation in gas chromatography Faster gas chromatography Multidimensional and comprehensive multidimensional gas chromatography On-line and at-line gas chromatography References Index.
Identification of a Group of Cellular Cofactors That Stimulate the Binding of RNA Polymerase II and TRP-185 to Human Immunodeficiency Virus 1 TAR RNA (1996)

A double-stranded RNA structure transcribed from the HIV-1 long terminal repeat known as TAR is critical for increasing gene expression in response to the transactivator protein Tat. Two cellular factors, RNA polymerase II and TRP-185, bind specifically to TAR RNA, but require the presence of cellular proteins known as cofactors which by themselves are unable to bind to TAR RNA. In an attempt to determine the mechanism by which these cofactors stimulate binding to TAR RNA, we purified these factors from HeLa nuclear extract and amino acid microsequence analysis performed. Three proteins were identified in the cofactor fraction including two previously described proteins, elongation factor 1alpha (EF-1alpha) and the polypyrimidine tract-binding protein (PTB), and a novel protein designated the stimulator of TAR RNA-binding proteins (SRB). SRB has a high degree of homology with a variety of cellular proteins known as chaperonins. Recombinant EF-1alpha, PTB, and SRB produced from vaccinia expression vectors stimulated the binding of RNA polymerase II and TRP-185 to TAR RNA in gel retardation analysis. These studies define a group of cellular factors that function in concert to stimulate the binding of TRP-185 and RNA polymerase II to HIV-1 TAR RNA.
<title>Dispersion compensation for acousto-optic scanning two-photon microscopy</title> (2002)

In laser scanning microscopy, acousto-optic (AO) deflection provides a means to quickly position a laser beam to random locations. Compared to conventional scanning using galvanometer-driven mirrors, this approach increases the frame rate and signal-to-noise ratio, and reduces time spent illuminating sites of no interest. However, AO scanning has not yet been applied to multi-photon microscopy, primarily, because the femtosecond laser pulses employed are subject to significant amounts of both temporal and spatial dispersion upon propagation through common AO materials. Temporal dispersion of ultrashort pulses - also known as group velocity dispersion (GVD) - is commonly compensated by the inclusion of a pre-chirper. However, because of the large GVD of AO materials, commonly used pre-chirper designs entail a rather large footprint (> 2 meters). Spatial dispersion of the scanned beam - arising from AO deflection being a wavelength-dependent diffraction process - limits the achievable spatial resolution. To address these problems, we developed: 1) a novel four-pass double-decker pre-chirper geometry that reduces the assembly's footprint by another factor of two relative to current designs, and 2) a single diffraction grating scheme for significantly reducing spatial dispersion. The presented findings enable the construction of an acousto-optic two-photon microscope (AO-TPM).
Internal model generation for evolutionary acceleration of automated robotic assembly optimization (2009)

While machine learning algorithms have been successfully applied to a myriad of task configurations for parameter optimization, without the benefit of a virtual representation to permit offline training, the learning process can be costly in terms of time being spent and components being worn or broken. Parameter spaces for which the model is not known or are too complex to simulate stand to benefit from the generation of model approximations to reduce the evaluation overhead. In this paper, we describe a computational learning approach for dynamically generating internal models for Genetic Algorithms (GA) performance optimization. Through the process of exploring the parameter gene pool, a stochastic search method can effectively build a virtual model of the task space and improve the performance of the learning process. Experiments demonstrate that, in the presence of noise, neural network abstractions of the mappings of sequence parameters to their resulting performances can effectively enhance the performance of stochastic parameter optimization techniques. And results are presented that illustrate the benefits of internal model building as it pertains to simulated experiments of complex problems and to physical trials in robot assembly utilizing an industrial robotic arm to put together an aluminum puzzle.
Facebook users have become much more private: A large-scale study (2012)

We investigate whether Facebook users have become more private in recent years. Specifically, we examine if there have been any important trends in the information Facebook users reveal about themselves on their public profile pages since early 2010. To this end, we have crawled the public profile pages of 1.4 million New York City (NYC) Facebook users in March 2010 and again in June 2011. We have found that NYC users in our sample have become dramatically more private during this period. For example, in March 2010 only 17.2% of users in our sample hid their friend lists, whereas in June 2011, just 15 months later, 52.6% of the users hid their friend lists. We explore privacy trends for several personal attributes including friend list, networks, relationship, high school name and graduation year, gender, and hometown. We find that privacy trends have become more pronounced for certain demographics. Finally, we attempt to determine the primary causes behind the dramatic decrease in the amount of information Facebook users reveal about themselves to the general public.
Nonpeptidic Foldamers from Amino Acids:  Synthesis and Characterization of 1,3-Substituted Triazole Oligomers (2005)

Nonpeptidic foldamers capable of displaying protein-like functionality were prepared by swapping amide bonds with 1,2,3-triazole rings. The overall conformation of these triazole oligomers is largely dictated by dipole-dipole interactions between adjacent rings. Solution NMR studies suggest that a zigzag conformation, which closely mimics the beta-strand structure, predominates in two different tetramers.
Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria (2017)

The majority of routinely given vaccines require two or three immunisations for full protective efficacy. Single dose vaccination has long been considered a key solution to improving the global immunisation coverage. Recent infectious disease outbreaks have further highlighted the need for vaccines that can achieve full efficacy after a single administration. Viral vectors are a potent immunisation platform, benefiting from intrinsic immuno-stimulatory features while retaining excellent safety profile through the use of non-replicating viruses. We investigated the scope for enhancing the protective efficacy of a single dose adenovirus-vectored malaria vaccine in a mouse model of malaria by co-administering it with vaccine adjuvants. Out of 11 adjuvants, only two, Abisco<sup>®</sup>-100 and CoVaccineHT<sup>TM</sup>, enhanced vaccine efficacy and sterile protection following malaria challenge. The CoVaccineHT<sup>TM</sup> adjuvanted vaccine induced significantly higher proportion of antigen specific central memory CD8<sup>+</sup> cells, and both adjuvants resulted in increased proportion of CD8<sup>+</sup> T cells expressing the CD107a degranulation marker in the absence of IFNγ, TNFα and IL2 production. Our results show that the efficacy of vaccines designed to induce protective T cell responses can be positively modulated with chemical adjuvants and open the possibility of achieving full protection with a single dose immunisation.
Zeeman-Doppler imaging of active stars. III: Instrumental and technical considerations (1993)

An account is given of the instrumental setup and observational procedure that led to the qualifying of Zeeman-Doppler imaging and to new detections of magnetic fields on four stars HR 1099, σ 2 CrB, II Peg and UX Ari
Acyclic diene metathesis copolymerization of 1,5-hexadiene and 1,9-decadiene (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcyclic diene metathesis copolymerization of 1,5-hexadiene and 1,9-decadieneK. B. Wagener, J. G. Nel, J. Konzelman, and J. M. BoncellaCite this: Macromolecules 1990, 23, 24, 5155–5157Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/ma00226a022https://doi.org/10.1021/ma00226a022research-articleACS PublicationsRequest reuse permissionsArticle Views480Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Central role of radical cations in metabolic activation of polycyclic aromatic hydrocarbons (1995)

1. Development of the chemistry of polycyclic aromatic hydrocarbon (PAH) radical cations has provided evidence that these intermediates play a major role in the metabolism of PAHs by P450 and in their binding to DNA. 2. Fluoro substitution of benzo[a]pyrene (BP) represents a suitable probe for studying mechanisms of oxygen transfer in the P450-catalysed formation of quinones and phenols from BP. Formation of BP-1,6-, -3,6- and -6,12-dione from the metabolism of 6-fluoroBP (6-FBP) is mediated by the intermediate 6-FBP+. Similarly, metabolism of 1-FBP and 3-FBP by rat liver microsomes produces BP-1,6-dione and BP-3,6-dione respectively. These results demonstrate that formation of quinones and phenols occurs via an initial electron transfer from BP to P450 and subsequent transfer of oxygen from the iron-oxo complex of P450 to BP. 3. Radical cations also play a major role in the formation of DNA adducts by the potent carcinogens 7,12-dimethylbenz[a]anthracene (DMBA), BP and dibenzo[a,l]pyrene (DB[a,l]P). In the binding of BP both in vitro and in vivo, 80% of the adducts are formed by one-electron oxidation, namely, 8-(BP-6-yl)guanine (BP-6-C8Gua), BP-6-N7Gua and BP-6-N7adenine (Ade), and are lost from the DNA by depurination. For DB[a,l]P, depurinating adducts formed from the radical cation, DB[a,l]P-10-C8Gua, DB[a,l]P-10-N7Gua, DB[a,l]P-10-N7Ade, and DB[a,l]P-10-N3Ade comprise 50% of the total DNA adducts. For DMBA, 99% of the adducts are depurinating adducts formed from the radical cation, 7-CH3BA-12-CH2-N7Gua and 7-CH3BA-12-CH2-N7Ade. 4. In summary, radical cations of PAHs play a major role in both the metabolism and metabolic activation leading to formation of DNA adducts that are critical in the mechanism of tumour initiation.
Bayesian classification of protein structural elements (2002)

Heuristic Bayesian classification is applied to the problem of defining and enumerating structural motifs present in protein macromolecular systems. The classification system used, Autoclass III, estimates the most probable number of classes and describes class membership in terms of both mean attribute value and expected variance. A database of 9556 protein structure segments, each five amino acids in length, was compiled from high resolution, high quality X-ray crystal structures in the Brookhaven Protein Databank. Coordinates for these segments were transformed to a translationally and rotationally invariant local reference frame, then classified.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Thermal Stability Study of a Solder-Impregnated No-Insulation HTS Coil Via a Raman-Based Distributed Optical Fiber Sensor System (2019)

Mechanical stability of no-insulation (NI) high-temperature superconducting (HTS) coils will be greatly enhanced after using a solder impregnation (SIM) method. For superconducting high-field magnet applications, besides the mechanical stability, the thermal stability of SIM coils is also a crucial parameter which needs to be investigated. Due to its high insulation, convenient installation, distributed temperature measurement, and insensitive to stress, a Raman-based optical distributed temperature sensor (RmDTS) system is an ideal option for monitoring the temperature of SIM coils. In this study, an NI HTS coil and an optical fiber were successfully impregnated together by solder. The critical current of SIM coil determined by the central magnetic field is 69 A. To create quench process, a dc current of 240 A was injected into an SIM coil, and the temperature of the coil was monitored by the RmDTS simultaneously. The test results show that the temperature of the SIM coil was unchanged although a four times Ic was applied.
Formylation of aromatic compounds with carbon monoxide in HSO3F-SbF5 uner atmospheric pressure (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormylation of aromatic compounds with carbon monoxide in HSO3F-SbF5 uner atmospheric pressureMutsuo Tanaka, Jun Iyoda, and Yoshie SoumaCite this: J. Org. Chem. 1992, 57, 9, 2677–2680Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/jo00035a024https://doi.org/10.1021/jo00035a024research-articleACS PublicationsRequest reuse permissionsArticle Views476Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts