gebhart/patrepeval huggingface dataset:
Analysis of gamma delta resolvase mutants in vitro: evidence for an interaction between serine-10 of resolvase and site I of res. (1986)

The resolvase encoded by the transposon gamma delta mediates a site-specific recombination between the two copies of gamma delta in a cointegrate molecule to yield the final products of transposition. Several mutants of resolvase that lack recombinational activity have been isolated previously, and one of these, which has a serine-to-leucine change at position 10, we have characterized in vitro. We also have constructed a serine-to-cysteine change at position 10 by in vitro mutagenesis and have analyzed this mutant protein in vitro. We find that the cysteine-10 mutant is defective in recombinational activity but binds to the recombinational site, res, similarly to wild-type, as assayed by gel electrophoresis of the protein-DNA complexes. In contrast, the leucine-10 mutant has a specific defect in complex formation with site I, which contains the recombinational crossover point, although it can bind and provide the ancillary functions of resolvase at sites II and III. It has been shown that a phosphoserine linkage is made to the DNA during recombination; because serine-10 is absolutely conserved amongst the family of homologous site-specific recombination proteins, it is a good candidate for the active-site serine. The properties of these resolvase mutants with substitutions at position 10 are consistent with this hypothesis and suggest that serine-10 is in close contact with the DNA at site I.
Differential localization of protein kinase C isozymes in U937 cells: evidence for distinct isozyme functions during monocyte differentiation (1995)

U937 human promonocytic leukemia cells express PKC isozymes beta 1, beta 2, epsilon and zeta. Indirect immunocytofluorescence using affinity-purified PKC-specific antibodies indicates that each of the endogenous PKC isozymes in U937 cells display a unique compartmentalization within the intact cell. PKC-beta 1 is distributed between two identifiable pools: a cytoplasmic pool which redistributes to the plasma membrane upon activation with acute phorbol ester-treatment, and a membrane-bound pool associated with intracellular vesicles containing beta 2-integrin adhesion molecules, cd11b and cd11c. The vesicle-associated PKC-beta 1 translocates with the secretory granules to the plasma membrane upon agonist-stimulated activation. PKC-beta 2 is associated with the microtubule cytoskeleton in resting cells. PKC overlay assays indicate that PKC-beta 2 binds to proteins associated with microtubules, and not directly to tubulin. PKC-epsilon is associated with filamentous structures in resting cells and redistributes to the perinuclear region upon activation with phorbol esters. In differentiated U937 cells, PKC-beta 1 remains associated with vesicles translocating from the trans-Golgi region to the plasma membrane and PKC-epsilon is primarily associated with perinuclear and plasma membranes. PKC-zeta, which does not respond to phorbol ester treatment, is primarily cytosolic in undifferentiated cells and accumulates in the nucleus of differentiated cells blocked in the G2 phase of the cell cycle. The data clearly demonstrate that individual PKCs localize to different subcellular compartments and promote the hypothesis that PKC subcellular localization is indicative of unique functions for individual PKC isozymes.
Atom Collision-Induced Resistivity of Carbon Nanotubes (2005)

We report the observation of unusually strong and systematic changes in the electron transport in metallic single-walled carbon nanotubes that are undergoing collisions with inert gas atoms or small molecules. At fixed gas temperature and pressure, changes in the resistance and thermopower of thin films are observed that scale as roughly M(1/3), where M is the mass of the colliding gas species (He, Ar, Ne, Kr, Xe, CH4, and N2). Results of molecular dynamics simulations are also presented that show that the maximum deformation of the tube wall upon collision and the total energy transfer between the colliding atom and the nanotube also exhibit a roughly M(1/3) dependence. It appears that the transient deformation (or dent) in the tube wall may provide a previously unknown scattering mechanism needed to explain the atom collision-induced changes in the electrical transport.
The Lower Extremity Functional Scale (LEFS): scale development, measurement properties, and clinical application. North American Orthopaedic Rehabilitation Research Network. (1999)

The LEFS is reliable, and construct validity was supported by comparison with the SF-36. The sensitivity to change of the LEFS was superior to that of the SF-36 in this population. The LEFS is efficient to administer and score and is applicable for research purposes and clinical decision making for individual patients.
Association of HPA axis genes with suicidal behaviour in schizophrenia (2008)

Family, adoption and twin studies show that genetics influences suicidal behaviour, but do not indicate specific susceptibility variants. Stress response is thought to be mediated by the corticotrophin-releasing hormone (CRH), which is known to be a regulator of the hypothalamic-pituitary-adrenal pathway (HPA). Alterations in HPA system have been related to impulsivity, aggression and suicidal behaviour, common feature in schizophrenia. CRH is the hypothalamic factor that stimulates the pituitary gland. To search for markers conferring genetic susceptibility to suicide, we typed six HPA axis genes (CRH, CRHR1, CRHR2, CRHBP, MC2R, NC3R1) in a cohort of 231 subjects with schizophrenia in which 81 attempted suicide. The genotype analyses yielded significant association between CRH binding protein (CRHBP) and suicide attempt (P = 0.035). The genotype analysis for quantitative measures of suicidal behaviour showed no association. The interaction analysis showed a significant interaction between CRH receptor type 1 (CRHR1) and CRH binding protein (CRHBP) in influencing suicide attempt and the severity of suicidal behaviour. Current results show that genetic variation in HPA axis genes could be associated with suicidal behaviour in schizophrenia. This is to our knowledge the first study on suicidal behaviour investigating the interaction among the HPA axis genes.
Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition. (2008)

Previous studies have shown that 17,19,21-tri-N-methyl-Abeta16-22 peptide (Abeta16-22m), and a peptide analogue containing alpha,alpha-disubstituted amino acids (alphaalpha AA) in the hydrophobic core domain of Abeta, termed AMY-1, effectively inhibited full-length Abeta aggregation in vitro. To investigate the amyloid-modifying effects of these agents in vivo, we injected these compounds into the hippocampus of 13-month-old amyloid precursor protein (APP) transgenic mice, a model of amyloid deposition. After 7 days, brain tissues were stained for immunohistochemistry to detect total Abeta and thioflavine-S (THIO-S) to measure Abeta compact plaques. Both diffuse Abeta deposits and compact amyloid plaques were significantly increased when injecting 0.3 nmol Abeta16-22m compared to the PBS vehicle. The amyloid aggregation-modifying peptide AMY-1 showed a slight reduction of Abeta deposition in the injection area at a dose of 0.3 nmol, but neuronal toxicity, measured by Fluoro-Jade and Nissl stains, appeared when higher doses (3 nmol) were tested. Our data indicate that, unlike observations reported in vitro, the Abeta16-22m increased deposition of Abeta in the brain of APP transgenic mice in vivo. Possible explanations for this outcome include unique influences of the brain environment and/or modification of Abeta production or clearance by the administered agent. The AMY-1 peptide showed a trend for reducing Abeta deposits, but led to toxicity at higher doses. These data emphasize the need for evaluating potential Abeta aggregation inhibitors with in vivo models of amyloid deposition before assuming they will have benefit in treating Alzheimer's disease patients.
The damaging punch. (1985)

The mechanical properties of a boxing punch have been determined using several techniques. The results are consistent with the medical consequences of boxing discussed in the report of the Board of Science and Education Working Party on boxing. Data were gathered from a world ranked British professional heavyweight, Frank Bruno, as he punched an instrumented, padded target mass suspended as a ballistic pendulum. Within 0.1 s of the start the punch had travelled 0.49 m and attained a velocity on impact of 8.9 m/s. The peak force on impact of 4096N (0.4 ton), attained within 14 ms of contact, represents a blow to the human head of up to 6320N (0.63 ton). The transmitted impulse generated an acceleration of 520 m/s2 (53 g) in the target head. For comparison an equivalent blow would be delivered by a padded wooden mallet with a mass of 6 kg (13 lbs) if swung at 20 mph.
Was Edwin Drood Murdered? Part One (1949)

Research Article| September 01 1949 Was Edwin Drood Murdered? Part One Richard M. Baker Richard M. Baker Search for other works by this author on: This Site PubMed Google Scholar Trollopian (1949) 4 (2): 111–128. https://doi.org/10.2307/3044142 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Richard M. Baker; Was Edwin Drood Murdered? Part One. Trollopian 1 September 1949; 4 (2): 111–128. doi: https://doi.org/10.2307/3044142 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentNineteenth-Century Literature Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
A review of research and innovation in garment sizing, prototyping and fitting (2015)

Achieving well fitting garments matters to consumers and, therefore, to product development teams, garment manufacturers and fashion retailers when creating clothing that fits and functions both for individuals and for a retailer's target populations. New tools and software for body scanning and product development enhance the ways that sizing and fitting can be addressed; they provide improved methods for classifying and analysing the human body and new ways of garment prototyping through virtual product development.Recent technological developments place a growing demand on product development teams to reconsider their approach to prototyping, sizing and fitting. Significant, related changes are also being made in the fashion retail environment, including innovations in virtual fit to enable consumers to engage with fit online. For best effect in the short term, such advances need to relate well to existing manufacturing practices and to the methods that have, over many years, become embedded by practitioners into the processes involved in clothing product development and those used for establishing garment fit.The high rate of technological advance, however, places an urgent need on practitioners to change; established principles of pattern theory need to be recognised explicitly and followed consistently, otherwise, new techniques for developing and assessing products will not be able to be fully exploited. Practitioners will be pressed to adopt more data-rational approaches to product development, including adopting engineering principles into the practice of clothing product development. For example, comparisons made between the traditional two-dimensional garment pattern and the three-dimensional environment accessible through 3-D body scanning technology, provide both the stimulus and the data required to support a re-examination of how the measurements required for clothing product development should be defined. This should be coupled with a more explicit recognition of ease as a factor requiring quantification within clothing engineering. New methods of categorising the body in terms of its form also allow recognition of the restrictions of proportional theories in pattern construction; they afford promising opportunities for advancing the practices of sizing and fitting in clothing product development.
Cognitive Impairment in Bipolar Disorder and Schizophrenia: A Systematic Review (2013)

Patients with BD might exhibit a cognitive impairment that could be similar to SZ in terms of their profile, although patients with SZ may have more severe and widespread impairments.
Low-complexity depth map compression in HEVC-based 3D video coding (2015)

In this paper, a low-complexity algorithm is proposed to reduce the complexity of depth map compression in the high-efficiency video coding (HEVC)-based 3D video coding (3D-HEVC). Since the depth map and the corresponding texture video represent the same scene in a 3D video, there is a high correlation among the coding information from depth map and texture video. An experimental analysis is performed to study depth map and texture video correlation in the coding information such as the motion vector and prediction mode. Based on the correlation, we propose three efficient low-complexity approaches, including early termination mode decision, adaptive search range motion estimation (ME), and fast disparity estimation (DE). Experimental results show that the proposed algorithm can reduce about 66% computational complexity with negligible rate-distortion (RD) performance loss in comparison with the original 3D-HEVC encoder.
Hypocholesterolemic actions of atorvastatin are associated with alterations on hepatic cholesterol metabolism and lipoprotein composition in the guinea pig (1996)

Guinea pigs were fed 15% (w/W) fat, high in lauric and myristic acids, a diet known to produce hypercholesterolemia in these animals. The diet was given alone or in combination with four doses of atorvastatin equivalent to 1, 3, 10, and 20 mg/kg per day. Atorvastatin reduced plasma LDL cholesterol concentrations by 46, 50, 53, and 70%, respectively (P < 0.001). Plasma apoB concentrations were reduced by atorvastatin (P < 0.001) and compositional changes occurred in VLDL and LDL with reductions of the relative proportion of cholesteryl ester and increases in triacylglycerol. A reduction in hepatic cholesteryl ester (66%) was observed only with the highest atorvastatin dose (20 mg/kg per day) while microsomal cholesterol was reduced by 30% with 3-20 mg/kg per day. Hepatic ACAT activity was down-regulated and apoB/E receptor number was increased by atorvastatin. In contrast, HMG-CoA reductase activity and cholesterol 7 alpha-hydroxylase were not affected by the drug. VLDL apoB secretion rates were decreased by atorvastatin treatment 59 and 76% with 3 and 20 mg/kg per day, respectively. Nascent VLDL particles were larger after drug treatment, showing an increased number in triacylglycerol molecules. These results support the hypothesis that the plasma LDL lowering induced by atorvastatin is due to a decreased secretion of apoB in combination with an increase of hepatic apoB/E receptors.
FECk: A New Efficient Clustering Algorithm for the Events Correlation Problem in Telecommunication Networks (2007)

In this paper we introduce an efficient clustering algorithm embedded in a novel approach for solving the problem of faults identification in large telecommunication networks. Our algorithm is especially designed for the event correlation problem taking into account comprehensive information about the system behaviour. Although alarms are usually useful for identifying faults in such systems, their large number overloads the current management systems, making it extremely difficult to provide an answer within a reasonable response time. The alarm flow presents some interesting characteristics like alarm storm and alarm cascade. For instance, a single fault may result in a large number of alarms, and it is often very difficult to isolate the true cause of the fault. One way of overcoming this problem is to analyze, interpret and reduce the number of these alarms before trying to localize the faults. In this paper, we present FEC <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</sub> , and we compare it with some available clustering algorithms by experimenting them with some samples from both simulated and real data from Ericsson's network.
An object-oriented nano-kernel for operating system hardware support (2002)

The nano-kernel in the /spl mu/Choices operating system provides hardware support for the operating system. The nano-kernel is a single, modular subsystem that encapsulates the hardware and presents an idealized machine architecture to the rest of the system. Higher levels of the system that implement policy access the nano-kernel through a single interface. Thus the /spl mu/Choices nano-kernel is fully decoupled from higher level abstractions such as virtual memory or process paradigms. Within the nano-kernel, the hardware is modeled as a collection of abstract classes in a hardware support framework that are subclassed for particular hardware platforms. This architecture provides a highly modular and portable design making the system vastly easier to work with than previous versions of Choices. We have implemented a prototype of /spl mu/Choices that runs on UNIX.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Identification of Hexose Transporter-Like Sensor <i>HXS1</i> and Functional Hexose Transporter <i>HXT1</i> in the Methylotrophic Yeast <i>Hansenula polymorpha</i> (2008)

We identified in the methylotrophic yeast Hansenula polymorpha (syn. Pichia angusta) a novel hexose transporter homologue gene, HXS1 (hexose sensor), involved in transcriptional regulation in response to hexoses, and a regular hexose carrier gene, HXT1 (hexose transporter). The Hxs1 protein exhibits the highest degree of primary sequence similarity to the Saccharomyces cerevisiae transporter-like glucose sensors, Snf3 and Rgt2. When heterologously overexpressed in an S. cerevisiae hexose transporter-less mutant, Hxt1, but not Hxs1, restores growth on glucose or fructose, suggesting that Hxs1 is nonfunctional as a carrier. In its native host, HXS1 is expressed at moderately low level and is required for glucose induction of the H. polymorpha functional low-affinity glucose transporter Hxt1. Similarly to other yeast sensors, one conserved amino acid substitution in the Hxs1 sequence (R203K) converts the protein into a constitutively signaling form and the C-terminal region of Hxs1 is essential for its function in hexose sensing. Hxs1 is not required for glucose repression or catabolite inactivation that involves autophagic degradation of peroxisomes. However, HXS1 deficiency leads to significantly impaired transient transcriptional repression in response to fructose, probably due to the stronger defect in transport of this hexose in the hxs1Delta deletion strain. Our combined results suggest that in the Crabtree-negative yeast H. polymorpha, the single transporter-like sensor Hxs1 mediates signaling in the hexose induction pathway, whereas the rate of hexose uptake affects the strength of catabolite repression.
The concentration distributions of some metabolites in the exhaled breath of young adults (2007)

The concentrations of ammonia, acetone, methanol, ethanol, propanol and hydrogen cyanide have been measured in the exhaled breath of 26 young adults of age 17/18 years, using selected ion flow tube mass spectrometry (SIFT-MS). Thus the concentration distributions have been constructed and are seen to be essentially log normal with median values in parts per billion (ppb), being ammonia, 317; acetone, 363; methanol, 238; ethanol, 104; propanol, 13; hydrogen cyanide (HCN), 8. There is a clear separation in the median breath ethanol levels between those volunteers who had ingested sugary food/drinks (109 ppb) and those who had not (48 ppb). These data are compared with the results of a study of the same breath compounds, excepting HCN, for a similar sized cohort of healthy volunteers within the age range of 20 to 60 years, which shows that the median levels of these compounds are lower in the young adult volunteer cohort. These HCN measurements are the first to be made in the breath of healthy individuals. The potential implications of these combined results for clinical diagnosis are alluded to.
Xl erg: Expression pattern and overexpression during development plead for a role in endothelial cell differentiation (1999)

The ets gene family encodes transcription factors related to the proto-oncogene c-ets-1 and involved in cell proliferation, differentiation, and oncogenic transformation. We have characterized the Xenopus homologue of the human erg gene, an ets-related-gene, and its expression has been examined throughout early embryonic development. Xl erg encodes at least two proteins, resulting from alternative splicing events. The transcripts are restricted to the forming endocardium, the endothelial cells of the blood vessels and to the neural crest-derived mesenchyme cells of the pharyngial arches. When Xl ERG is expressed ectopically in Xenopus embryos by microinjection of synthetic mRNA, multiple developmental defects are observed. Dorsally injected embryos have their AP axis shortened and present severe defects in eye and somite morphogenesis. Ventrally injected embryos show a posteriorization of the cells having received the message together with ectopic endothelial cell differentiation as revealed by the accumulation of X-msr transcripts. In both cases, accumulation of erythrocytes in structures not connected with the blood circulatory system can be observed. Our data suggest that Xl erg may be involved in cell motility and in the development of the circulatory system.
Privacy-Preserving Transactions Protocol Using Mobile Agents with Mutual Authentication (2007)

This article introduces a new transaction protocol using mobile agents in electronic commerce. The authors first propose a new model for transactions in electronic commerce, mutual authenticated transactions using mobile agents. They then design a new protocol by this model. Furthermore, the authors analyse the new protocol in terms of authentication, construction, and privacy. The aim of the protocol is to guarantee that the customer is committed to the server, and the server is committed to the customer. At the same time, the privacy of the customer is protected.
Growth inhibition of yeast by compactin (ML-236B) analogues. (1988)

Compactin (ML-236B) (Fig.
Dimensional limitations of silicon nanolines resulting from pattern distortion due to surface tension of rinse water (1995)

In a nanometer-scale regime, high-aspect-ratio Si lines running in parallel bend plastically toward each other during the drying process after being rinsed in water. Pattern distortion occurs when the line distance is smaller than the product of the squared aspect ratio and a constant k dependent on the condition of the Si surface, i.e., (distance)&lt;k×(aspect ratio)2. This relationship can be derived theoretically on the assumption that water remains between lines and the water pressure is reduced due to the surface tension of water.