gebhart/patrepeval huggingface dataset:
Unsaturated Polyester Resins from Epoxides and Anhydrides (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnsaturated Polyester Resins from Epoxides and AnhydridesH. G. Waddill, J. G. Milligan, and W. J. PeppelCite this: Ind. Eng. Chem. Prod. Res. Dev. 1964, 3, 1, 53–55Publication Date (Print):March 1, 1964Publication History Published online1 May 2002Published inissue 1 March 1964https://pubs.acs.org/doi/10.1021/i360009a014https://doi.org/10.1021/i360009a014research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A self-aligning scanning optical delay line (1984)

A self-aligning scanning optical delay line is described for use in picosecond pulse-probe experiments. The position of a retroreflected beam is monitored and the signal is fed back to motor-driven micrometers that control the retroreflector position.
<i>In vitro</i>culture of testicular germ cells: Regulatory factors and limitations (2007)

Spermatogenesis is regulated mainly by endocrine factors and also by testicular paracrine/autocrine growth factors. These factors are produced by Sertoli cells, germ cells, peritubular cells and interstitial cells, mainly Leydig cells and macrophages. The interactions and the ratio between Sertoli and germ cells in the seminiferous tubules ensure successful spermatogenesis. In order to culture spermatogonial stem cells (SSCs) in vitro, researchers tried to overcome some of the obstacles—such as the low number of stem cells in the testis, absence of specific markers to identify SSCs—in addition to difficulties in keeping the SSCs alive in culture. Recently, some growth factors important for the proliferation and differentiation of SSCs were identified, such as glial cell line derived neurotrophic factor (GDNF), stem cell factor (SCF) and leukemia inhibitory factor (LIF); also, markers for SSCs at different stages were reported. Therefore, some groups succeeded in culturing SSCs (under limitations), or more differentiated cells and even were able to produce in vitro germ cells from embryonic stem cells.Thus, success in culturing SSCs is dependent on understanding the molecular mechanisms behind self-renewal and differentiation. Culture of SSCs should be a good tool for discovering new therapeutic avenue for some infertile men or for patients undergoing chemotherapy/radiotherapy (pre-puberty or post-puberty).
Low Complexity Decoders for Constant Envelope Digital Modulations (1983)

Digital angle modulations having input symbol memory can be demodulated using maximum likelihood sequence estimation (MLSE or Viterbi decoding). The demodulation of the more bandwidth efficient of these can require a large number of computations. In this paper, lower complexity decoding approaches are presented. These decoders use a predetermined processing order and a reduced number of survivor signals, <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S</tex> , at every-time <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">NT</tex> . Processing is performed on the signal sequences using metrics (likelihoods) obtained by a matched filter bank similar to that needed for MLSE. The decoders can achieve asymptotic optimality of error rate while being computationally faster and simpler than MLSE for many modulations. In addition, error rate performance can be traded for complexity reduction. Expected performance has been verified for representative modulations.
Novel Slurry Electrolyte Containing Lithium Metasilicate for High Electrochemical Performance of a 5 V Cathode (2015)

We report a novel slurry electrolyte with ultrahigh concentration of insoluble inorganic lithium metasilicate (Li2SiO3) that is exploited for lithium ion batteries to combine the merits of solid and liquid electrolytes. The safety, conductivity, and anodic and storage stabilities of the eletrolyte are examined, which are all enhanced compared to a base carbonate electrolyte. The compatibility of the elecrolyte with a LiNi0.5Mn1.5O4 cathode is evaluated under high voltage. A discharge capacity of 173.8 mAh g(-1) is still maintained after 120 cycles, whereas it is only 74.9 mAh g(-1) in the base electrolyte. Additionally, the rate capability of the LiNi0.5Mn1.5O4 cathode is also improved with reduced electrode polarization. TEM measurements indicate that the electrode interface is modified by Li2SiO3 with a thinner solid electrolyte interphase film. Density functional theory computations demonstrate that LiPF6 is stabilized against its decomposition by Li2SiO3. A possible path for the reaction between PF5 and Li2SiO3 is also proposed by deducing the transition states involved in the process using the DFT method.
Analysis of supply chains using system dynamics, neural nets, and eigenvalues (2004)

Supply chain management is a critically significant strategy that enterprises depend on in meeting the challenges of today's highly competitive and dynamic business environments. An important aspect of supply chain management is how enterprises can detect the supply chain behavioral changes due to endogenous and/or exogenous influences and to predict such changes and their impacts in the short and long term horizons. A methodology for addressing this problem that combines system dynamics and neural networks analysis is proposed in this paper. We use neural networks' pattern recognition abilities to capture a system dynamics model and analyze simulation results to predict changes before they take place. We also describe how eigenvalue analysis can be used to enhance the understanding of the problematic behaviors. A case study in the electronics manufacturing industry is used to illustrate the methodology.
Tadalafil Augments Tumor Specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma (2015)

Abstract Purpose: To determine if phosphodiesterase 5 (PDE5) inhibitors can augment immune function in patients with head and neck cancer through inhibition of myeloid-derived suppressor cells (MDSC). Experimental Design: We performed a randomized, prospective, double blinded, placebo controlled, phase II clinical trial to determine the in vivo effects of systemic PDE5 inhibition on immune function in patients with head and neck squamous cell carcinoma (HNSCC). Results: Tadalafil augmented immune response, increasing ex vivo T-cell expansion to a mean 2.4-fold increase compared with 1.1-fold in control patients (P = 0.01), reducing peripheral MDSC numbers to mean 0.81-fold change compared with a 1.26-fold change in control patients (P = 0.001), and increasing general immunity as measured by delayed type hypersensitivity response (P = 0.002). Tumor-specific immunity in response to HNSCC tumor lysate was augmented in tadalafil-treated patients (P = 0.04). Conclusions: These findings demonstrate that tadalafil augments general and tumor-specific immunity in patients with HNSCC and has therapeutic potential in HNSCC. Evasion of immune surveillance and suppression of systemic and tumor-specific immunity is a significant feature of head and neck cancer development. This study demonstrates that a PDE5 inhibitor, tadalafil, can reverse tumor-specific immune suppression in patients with head and neck cancer, with potential for therapeutic application. Clin Cancer Res; 21(1); 30–38. ©2015 AACR.
Perinatal infection by human immunodeficiency virus type 1 (HIV–1): Relationship between proviral copy number in vivo, viral properties in vitro, and clinical outcome (1991)

Human immunodeficiency virus type 1 (HIV-1) isolates from 25 perinatally HIV-1 infected children were classified according to their capacity to replicate in vitro as rapid (R), intermediate (S/R) and slow (S) variants. R-type viruses replicated on peripheral blood mononuclear cells (PBMCs) and grew better in T-lymphoid cells, even though 9 out of 12 isolates also maintained tropism for monocytoid cells. The S/R-type isolates replicated efficiently after several days of culture, while the S-type viruses displayed only a low and transient replication activity; however, both S/R- and S-type isolates exerted viral transactivation activity in an indicator monocytoid cell line. Replication patterns in vitro were significantly associated in vivo with the number of HIV-1 copies in PBMCs as determined by polymerase chain reaction: in children with R-type isolates, the number of HIV-1 proviral DNA molecules/10(5) PBMCs ranged from 62 to 571, and in children with S/R and S isolates the range was 5-43. Seven children had severe symptomatic HIV-1 infection, and in all an R-type virus was identified; 18 children had no or only mild symptoms, and among these, S-, S/R-, and R-type isolates were found in 5, 8, and 5 cases, respectively. Besides demonstrating HIV-1 variability in perinatal infection, these findings suggest that R-type virus might be a prerequisite for disease progression.
Fast outer-loop link adaptation scheme realizing low-latency transmission in LTE-Advanced and future wireless networks (2016)

In this paper, a fast outer-loop link adaptation (OLLA) scheme is proposed to realize low-latency transmission. OLLA generally compensates for the estimated signal-to-interference-plus-noise ratio (SINR) that is used to optimize the selection of a modulation and coding scheme (MCS) based on the reception of a positive acknowledgement (ACK) or a negative acknowledgement (NAK) for a Hybrid ARQ (HARQ) initial transmission. The proposed scheme controls the size of the compensation in the estimated SINR based on the time elapsed after a user equipment (UE) transits from an idle state to an active state. The computer simulation result shows that the proposed scheme can achieve a high throughput just after UE starts its data transmission that is otherwise impossible if using the conventional scheme. This performance helps shorten the latency of transmission, especially in small-packet applications.
Structure−Activity Relationship Studies of Phenanthridine-Based Bcl-X<sub>L</sub> Inhibitors (2008)

Despite their structural similarities, the natural products chelerythrine ( 5) and sanguinarine ( 6) target different binding sites on the pro-survival Bcl-X L protein. This paper details the synthesis of phenanthridine-based analogues of the natural products that were used to probe this difference in binding profiles. The inhibitory constants for these compounds were then measured in a fluorescence polarization assay against Bcl-X L and the tagged Bak-BH3 peptide. The results led to structure-activity relationship studies, which identified the structural motifs required for binding-site specificity as well as inhibitory activity. We also identified synthetic analogues of the natural products that display similar binding modes but with more potent IC 50 values.
Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2. (2011)

AAV2-mediated retinal transduction is improved by co-injection of heparinase III or chondroitin ABC lyase. Improved transduction efficiency may allow intravitreal injection to become the preferred route for delivering gene therapy to both the inner and outer retina.
A 1024-element high-performance silicon tactile imager (2003)

A 32-*32-element capacitive silicon tactile imager has been developed for use in precision robotics applications where high density and high resolution are important. The silicon chip measures 1.8 cm*1.7 cm and is organized in an X-Y matrix of 1024 capacitor elements on 0.5-mm centers. The process uses two boron diffusions (deep and shallow) followed by a silicon-to-glass electrostatic bonding step and subsequent unmasked wafer dissolution. This results in a thick center plate for the sense capacitor supported by thinner beams. A data acquisition system used with the device offers over 7-bit force resolution with a maximum operating force of about 1 gm/element.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rumen microbial communities influence metabolic phenotypes in lambs (2015)

The rumen microbiota is an essential part of ruminants shaping their nutrition and health. Despite its importance, it is not fully understood how various groups of rumen microbes affect host-microbe relationships and functions. The aim of the study was to simultaneously explore the rumen microbiota and the metabolic phenotype of lambs for identifying host-microbe associations and potential biomarkers of digestive functions. Twin lambs, separated in two groups after birth were exposed to practices (isolation and gavage with rumen fluid with protozoa or protozoa-depleted) that differentially restricted the acquisition of microbes. Rumen microbiota, fermentation parameters, digestibility and growth were monitored for up to 31 weeks of age. Microbiota assembled in isolation from other ruminants lacked protozoa and had low bacterial and archaeal diversity whereas digestibility was not affected. Exposure to adult sheep microbiota increased bacterial and archaeal diversity independently of protozoa presence. For archaea, Methanomassiliicoccales displaced Methanosphaera. Notwithstanding, protozoa induced differences in functional traits such as digestibility and significantly shaped bacterial community structure, notably Ruminococcaceae and Lachnospiraceae lower up to 6 folds, Prevotellaceae lower by ~40%, and Clostridiaceae and Veillonellaceae higher up to 10 folds compared to microbiota without protozoa. An orthogonal partial least squares-discriminant analysis of urinary metabolome matched differences in microbiota structure. Discriminant metabolites were mainly involved in amino acids and protein metabolic pathways while a negative interaction was observed between methylotrophic methanogens Methanomassiliicoccales and trimethylamine N-oxide. These results stress the influence of gut microbes on animal phenotype and show the potential of metabolomics for monitoring rumen microbial functions.
A fast collision check algorithm EDGE for moving 3D objects (2002)

We propose an octree-based collision check algorithm EDGE for multiple manipulators with many degrees-of-freedom. The manipulator consists of many links, and therefore it should plan a collision-free sequence of motions by a collision check between two moving 3D links. In previous octree-based algorithms, we drop each patch of an object on an octree of another object to investigate their collision. In our proposed algorithm, we drop each edge of an object on an octree of another object to find the collision. With our algorithm, tracing the edge is much faster than covering the patch on the octree. For this purpose, we first develop an efficient algorithm for finding neighbor nodes (cubes) along an edge in an octree. Next, we build a collision check algorithm with the support of the neighbor finding algorithm.
Radioactive seed localization of renal cell carcinoma in a patient with Von Hippel‐Lindau disease (2016)

This report describes the case of a patient, who had successful radioactive seed localization (RSL) performed to improve the identification and excision of a renal cell carcinoma. RSL is a new method of preoperative localization, which can ease the surgical procedure, minimize tissue trauma, and ultimately benefit the patient.
Particle size distributions by laser diffraction: sensitivity of granular matter strength to analytical operating procedures (2010)

Abstract. We tested laser diffraction particle size analysis in poorly coherent carbonate platform cataclastic breccias and unfaulted quartz-rich eolian sands, representing low- and high-strength granular materials, respectively. We used two different instruments with different sample dispersion and pumping systems and several wet analytical procedures that included different pump speeds, measurement precision tests with and without sample ultrasonication, and different dispersant liquids. Results of our work indicate that high strength material is not strongly affected by analytical operating procedures, whereas low strength materials are very sensitive to the pump speed, ultrasonication intensity, and measurement run time. To reduce such a data variability, we propose a workflow of analytical tests preliminary to the set up of the most appropriate SOP.
Detection of open fractures with vertical seismic profiling (1985)

In vertical seismic profiling surveys, tube waves are generated by compressional waves impinging on subsurface fractures or permeable zones. The problem of generation of these waves by a nonnormal incident P wave for an inclined borehole intersecting a tilted parallel‐wall fracture is formulated theoretically. The amplitude of tube waves depends on the permeability, the length of the fracture, and the frequency. The relative effects of these parameters are studied individually. The problem is also formulated for a thin oblate ellipsoidal (penny‐shaped) fracture. The results for the two fracture models are compared and contrasted. Field data from Tyngsboro, Massachusetts, are shown for open fractures in granite. From tube wave amplitudes normalized to P wave amplitudes, calculated permeabilities are of the order of 100 mdarcy.
Jitter Effect on a Digital IF Transceiver for SDR-based Mobile communication Base Station (2007)

This paper outlines the time jitter effect of a sampling clock on a Software Defined Radio (SDR) technology- based-Digital Intermediate Frequency (IF) transceiver for a mobile communication base station. The implemented Digital IF transceiver is reconfigurable to three bandwidth profiles : 1.75 MHz, 3.5 MHz, and 7 MHz each incorporating the IEEE 802.16d Worldwide Interoperability for Microwave Access (WiMAX) standard and High-Speed Downlink Packet Access (HSDPA) standard. This transceiver can be reconfigured to other standard profiles through software downloaded onto identical hardware platforms, without changing any components or parts on board. This paper examines the relationship between the Signal-to- Noise Ratio (SNR) characteristics of a Digital IF transceiver with an under-sampling scheme and the sampling jitter effect on a multi-channel OFDM signal and a multi-code CDMA signal. The experimental results show that the SNR of the multi-channel OFDM system is more susceptible to sampling clock jitter compared to a multi-code HSDPA system.
SAR and 3D-QSAR Studies on Thiadiazolidinone Derivatives:  Exploration of Structural Requirements for Glycogen Synthase Kinase 3 Inhibitors (2005)

The 2,4-disubstituted thiadiazolidinones (TDZD) are described as the first ATP-noncompetitive GSK-3 inhibitors. Following an SAR study about TDZD, different structural modifications in the heterocyclic ring aimed to test the influence of each heteroatom on the biological study are here reported here. Various compounds such as hydantoins, dithiazolidindiones, rhodanines, maleimides, and triazoles were synthesized and screened as GSK-3 inhibitors. After an extensive SAR study among these different heterocyclic families, TDZDs have been revealed as a privileged scaffold for the selective inhibition of GSK-3. A CoMFA analysis was also performed highlighting the molecular electrostatic field interaction in the interaction of TDZDs with GSK-3. Moreover, first mapping studies indicate two binding modes which in turn might imply relevant differences in the mechanism that underly the inhibitory activity of TDZDs.
Medium-power GaAs field-effect transistors (1975)

Results on medium-power GaAs m.e.s.f.e.t.s. are described. Output powers as high as 300 mW at 9 GHz at 1 dB gain compression with a linear gain of 5.2 dB and drain efficiency of 30% have been obtained with single-cell m.e.s.f.e.t.s. At 4 GHz, a power output of 665 mW at 1 dB gain compression, a linear gain of 8 dB and a drain efficiency of 44.5% were realised with a 3-cell m.e.s.f.e.t. Two-tone intermodulation characteristics at 4 GHz are also described. A major innovation has been the use of a high-resistivity chromium-doped epitaxial GaAs buffer layer to isolate the device active region from the bulk-grown substrate.
Experimental characterization towards an in-fibre integrated silicon slab based all-optical modulator (2017)

Due to the industrially increasing interest in optics communication the field of all-optical modulation is becoming more and more popular. However, no in-fibre integrated miniaturized devices which provide current solutions were suggested as all-optical modulators with sufficient modulation depth and with low power consumption. In this paper, an all-optical silicon modulator with improved modulation depth is presented. The modulator will be developed as an in-fibre device for optics communication applications. The modulator is a silicon slab, 50 and 470 μm thick which is coated on both sides to get an improved Fabry-Perot resonator for laser beam at wavelength of 1550 nm. The modulator operation is based on the plasma dispersion effect which is induced by a pulsed visible laser beam acting as the pump for the creation of free charge carriers. We have proved the coating withstands high energy fluency of the laser pulse. The different recombination and heat processes are examined. Our silicon based Fabry-Perot resonator increases the intrinsic c-Si finesse to 30. The improved finesse is shown to have significant effect on the modulation depth up to 12 dB. To the best of our knowledge this is the first experimental feasibility study of an all-optical modulator with sufficient modulation depth and with low power consumption which is also an in-fibre integrated miniaturized device based upon Si slab. Extensive experimental and numerical studies presented in this paper examine the influence of thermal effects and the sample parameters on the response time and on the modulation depth and the power consumption of the in-fibre integrated device. Apart from being a modulator, the proposed device can also act as tunable spectral filter.