gebhart/patrepeval huggingface dataset:
Elevated expression of S100P, CAPL and MAGE 3 in doxorubicin-resistant cell lines (1998)

Subtractive suppressive hybridization (SSH) and mRNA differential display reverse transcription-polymerase chain reaction (DDRT-PCR) were compared for their ability to detect the expression of drug-resistance associated genes in a doxorubicin-resistant and -sensitive colon carcinoma cell line (LoVo H67P). The expression pattern of more than 9000 bands obtained by DDRT-PCR were identical in both cell lines by more than 95%. Of the remaining differentially expressed DDRT-PCR products, 21 cDNA fragments were further analyzed after cloning. A total of 210 clones were sequenced resulting in 40 different sequences of which only five were differentially expressed as revealed by Northern blot analysis. SSH, on the other hand, resulted in 30 different sequences of 37 clones analyzed. Thirteen of 30 sequences (43%) could be identified by databank analysis (excluding expressed sequence tags) in contrast to nine of 40 clones (23%) obtained by DDRT-PCR. Of the clones identified by SSH, 60% exhibited a differential expression comparing the doxorubicin-resistant and -sensitive cell line, respectively, as compared to only 13% of the DDRT-PCR derived clones. The application of SSH resulted in the identification of differentially expressed genes in three doxorubin-resistant cell lines (LoVo DxR, ARH D60 and KB-V1) as compared to the sensitive parental cell lines. A significant higher expression of S100P, a protein involved in calcium metabolism, as well as MAGE 3 (melanoma antigen gene) was found in the resistant cell lines using this methodology. The expression of CAPL, a second protein involved in calcium metabolism, was only moderately elevated in the doxorubicin-resistant cells. We found that subtractive suppressive hybridization proved to be a more rapid and reliable method for the detection of differentially expressed mRNAs in our system.
Design and Manufacturing of Hierarchical Multi-Functional Materials Via High Resolution additive Manufacturing (2017)

This master's thesis deals with the challenges of undesirable thermal expansion in lightweight materials. Thermal expansion of parts or components can lead to malfunction or breakdowns of complete systems in demanding environment where a large temperature gradient often exists. This work investigates a class of lightweight materials of which the thermal expansion coefficient can be controlled. Moreover, an additive manufacturing approach to produce these thermal management materials with high fidelity and reliability are critical to reach this goal. To achieve these two major research objectives analytic predictions, simulations, and measurement of thermal expansion coefficient with respect to temperature changes are conducted. Design and optimization of a high precision multi-material manufacturing apparatus has been conducted, leading to significant increase in production quality including reliability, efficiency, and costs.
A Framework for Integration of Radio Frequency Identification and Rich Internet Applications (2007)

Maturation and proliferation of radio frequency identification (RFID) and Web technologies has paved way for convergence of these hitherto separate technological branches. Near field communication (NFC), a derivative of RFID, has been introduced in mobile phones to enable short-range contactless identification in consumer services. Coming of age of Internet has brought along several fully fledged and standardized technologies, including JavaScript, CSS, DOM, and XML, for development of interactive and responsive browser applications, referred to as rich internet applications (RIA). In this paper we present and evaluate a framework for integration of NFC and rich Internet applications.
Bone Marrow Transplantation for Nonmalignant Diseases (2002)

Bone marrow transplantation (BMT) has emerged as a major therapeutic option for a number of nonmalignant disorders affecting the bone marrow and leading to clinical manifestations most likely affecting distant organs. Disorders such as autoimmune diseases, metabolic disorders, hemoglobinopathies, immunodeficiencies, and others have been the target of high-dose therapy and autologous or allogeneic bone marrow, stem cell, or cord blood transplantation. Successful results have been reported in a large number of these disorders. In most instances the goal of transplantation is to provide sufficient degree of marrow engraftment to allow long-term amelioration of disease phenotype. For many of these disorders, early diagnosis is crucial in achieving the desired results as transplantation becomes difficult when significant end-organ damage sets in. Major unsolved problems, including toxicity of conditioning regimens, graft-versus-host disease, and donor availability, need to be addressed. We attempt to provide a comprehensive review of BMT and discuss unique features of this modality for treatment of nonmalignant disorders.
Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation (2016)

A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.
Impact of Oil Prices on Stock Market Performance: Evidence from Top Oil Importing Countries (2019)

This study aims to analyze the impact of oil price on stock market performance in top oil importing countries. We used balanced panel data over a sample period of 1995 to 2017 with annual frequency. The sample data was gathered from World Development Indicator (WDI), Global Financial Indicator (GFDI) and West Texas Intermediate (WTI). The sample data were analyzed using regression test under the assumptions of Hausman test. Findings obtained from the fixed effect model suggest that oil price has a negative and insignificant impact on stock market. Similarly, the exchange rate also showed negative and insignificant impact while inflation
Clinical applications of acoustic rhinometry. (2000)

The clinical value of acoustic rhinometry (AR) is its ability to measure the dimensions of the nasal cavity in terms of a curve describing the cross-sectional areas as a function of distance. This curve describes nasal airway patency and gives an impression of the degree of nasal obstruction. The method provides values before and after decongestion which allow to evaluate the cause of the nasal obstruction as mainly skeletal or mucosal. This makes AR a tool for diagnosis and follow-up of treatment in both rhinology and rhinosurgery. Similarly, AR is a reliable method to show the dimensional changes of the nasal cavity before and after a given treatment. In the evaluation of a surgical intervention it is reasonable to use decongested values. Turbinate surgery, septo- and rhinoplasty, orthognatic surgery and paranasal sinus surgery and their influence on the dimensions of the nasal cavity may be reflected by AR. The absolute minimum cross-sectional area, and cross-sectional areas and volumes at fixed distances are the recommended parameters to show dimensional changes after nasal surgery. The predictive value of AR, in relation to nasal obstruction, should have high specificity and sensitivity to be used in a clinical setting. It seems that the single variables do not provide enough information for the diagnosis of obstruction, and it has been stressed that the results should be interpreted together with rhinoscopy and subjective complaints. A statistical model based on questionnaire, rhinoscopic findings and several variables from AR has been proposed to increase the diagnostic specificity and sensitivity of AR.
Time-Delay Compensation in Environment Construction Using Laser Range Finder (2013)

Teleoperation is operating at a distance and thus extending human capabilities to performing tasks remotely by providing the operator with similar conditions as those at the remote location. Generally, operator should be supported in real-time with an accurate data about the teleoperation environment. This paper proposes a time-delay compensation method for real-time environment construction for vehicle teleoperation as a part of the work for modifying the well-developed Autonomous Ground Vehicle of Beijing Institute of Technology (BIT AGV) to be teleoperated using the Laser scanner data. The proposed Time-Delay Compensation Algorithm includes aprediction process of the vehicle position in the future time and an environment construction w. r. t. the predicted position when the vehicle is still in the current time. Results of the real and simulation experiments for the algorithm illustrate the simplicity in calculations, performance and effectiveness of the algorithm to compensate time-delay in environment construction for Vehicle Teleoperation.
Computer storage and retrieval of generic chemical structures in patents. 2. GENSAL, a formal language for the description of generic chemical structures (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComputer storage and retrieval of generic chemical structures in patents. 2. GENSAL, a formal language for the description of generic chemical structuresJohn M. Barnard, Michael F. Lynch, and Stephen M. WelfordCite this: J. Chem. Inf. Comput. Sci. 1981, 21, 3, 151–161Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/ci00031a010https://doi.org/10.1021/ci00031a010research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Effect of Sr Substitution on Structure and Thermal Diffusivity ofBa1-xSrxTiO3 Ceramic (2009)

Problem statement: The aim of this research was to study the effect of Sr substitution on structure and thermal diffusivity of Bal-xSrxTiO3 ceramic at room temperature. Approach: Structural and thermal diffusivity of Ba1-xSrxTiO3 were studied by performing X-ray diffraction and photoflash measurements. The effects of Sr substitution on the structure and on the thermal diffusivity of Ba1-xSrxTiO3 (0≤x≤1) were investigated. All samples were prepared by standard solid state reaction technique. Results: The results showed that by substituting of Ba2+ ion with the Sr2+ the crystallite size decreased. The effect made the thermal diffusivity of Ba1-xSrxTiO3 decreased from 11.30x10-3 cm2 sec-1 (for BaTiO3) to 6.467x10-3 cm2 sec-1 (for SrTiO3) as x varied from 0-1. Conclusion: This study showed a significant effect of structure on thermo-physical property of materials.
The nexus between Czech non-state actors and domestic foreign policy making in the EU presidency context (2011)

Holding the EU Council Presidency presented the Czech Republic with an unprecedented opportunity to leave its imprint on, among others, EU foreign policy making by co-shap- ing the EU's political agenda. Due to the predominantly intergovernmental character of EU foreign policy, understanding its initial step, namely domestic foreign policy preference formation, becomes crucial. Consequently, in a liberal intergovernmentalist fashion, this article studies whether non-state actors, namely non-governmental organizations and think- tanks, entered the process of preference formation in the Czech Republic in the period preceding the Presidency and during the Presidency itself. Alternatively, it studies whether the lack of access points at the national administration level results in an elitist, govern- ment-driven foreign policy preference formation. Based on two empirical case studies - on the Eastern Partnership initiative and EU energy security - this study finds that certain Czech non-state actors are more than only passive bystanders, as they use both (semi-)in- stitutionalized and ad-hoc access points to advocate their own interests and agendas at the state level.
Centralized mobility load balancing scheme in LTE systems (2011)

MLB (Mobility Load Balancing) is one of the use cases of SON (Self-Organizing Network) discussed in NGMN and 3GPP. The objective of MLB is to reduce the number of low throughput users and the call blocking rate, when cell loads such as radio resources are unbalanced among cells, by adjusting handover parameters. In this paper, we focus on adjusting the HO margin which is one of the handover parameters and propose a centralized solution for MLB where a central server decides optimal HO margins considering load distribution among cells. In addition, we also present simulations results to demonstrate that our proposed solution reduces the number of low throughput users compared with a distributed solution.
Blind equalization based on radius directed adaptation (2002)

A blind equalization algorithm, termed radius directed equalization (RDE), for quadrature amplitude modulation (QAM) signals based on the known modulus of the constellation symbol radii is described. For example, 16 QAM has three radii and 32 QAM has five radii. The algorithm uses the error between the equalizer output modulus and the nearest symbol radius to update the equalizer weights. The RDE algorithm provides faster convergence than the constant modulus algorithm (CMA) for QAM signals and is independent of the carrier offset. The algorithm is described in the context of blind carrier and baud clock recovery schemes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Early events in the immunopathogenesis of feline retrovirus infections (1991)

Feline leukemia virus and feline immunodeficiency virus (FIV) are lymphotropic retroviruses that cause a wide range of diseases in domestic cats. Although it is known that both viruses are capable of infecting T lymphocytes and that infected cats are lymphopenic, it was not known how infection with either virus might alter specific lymphocyte subpopulations. Using a panel of monoclonal antibodies to feline lymphocyte subpopulations, we examined, by use of flow cytometric analysis, lymphocyte changes in cats naturally infected with FeLV or FIV and explored the early stages in the immunopathogenesis of experimentally induced infection with these viruses. Both groups of naturally infected cats had T-cell lymphopenia. In the FIV-infected cats, the T-cell decrease was principally attributable to loss of CD4+ cells, whereas CD8+ and B-cell numbers remained normal. This led to inversion of the CD4+ to CD8+ ratio in these cats. In contrast, the T-cell lymphopenia in FeLV-infected cats resulted from decrease in CD4+ and CD8+ cells, which led to a CD4+ to CD8+ ratio within normal limits. Experimentally induced infection with these 2 viruses supported these findings. Infection with FIV induced early (10 weeks after infection), chronic inversion of the CD4+ to CD8+ ratio. In contrast, infection with FeLV did not alter CD4+ to CD8+ ratio in the first 20 weeks after infection.
Assessment of an <sup>18</sup>F-Labeled Phosphoramidate Peptidomimetic as a New Prostate-Specific Membrane Antigen–Targeted Imaging Agent for Prostate Cancer (2009)

(18)F-labeled phosphoramidate (3) is a representative of a new class of PSMA targeting peptidomimetic molecules that shows great promise as imaging agents for detecting PSMA+ prostate tumors.
The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes (2001)

The agouti gene codes for agouti signaling protein (ASP), which is temporally expressed in wild-type mouse follicular melanocytes where it induces pheomelanin synthesis. Studies using purified full-length agouti signaling protein has shown that it competes with (&agr;)-melanocyte stimulating hormone for binding to the melanocortin 1 receptor. We have investigated whether ASP binds exclusively to the melanocortin 1 receptor expressed on mouse melanocytes in primary culture, or additionally activates a receptor that has not been identified yet. We have compared the responses of congenic mouse melanocytes derived from C57 BL/6J-E(+)/E(+), e/e, or E(so)/E(so) mice to (alpha)-MSH and/or ASP. E(+)/E(+) melanocytes express the wild-type melanocortin 1 receptor, e/e melanocytes express a loss-of-function mutation in the melanocortin 1 receptor that results in a yellow coat color, and E(so)/E(so) is a mutation that causes constitutive activation of the melanocortin 1 receptor and renders melanocytes unresponsive to (alpha)-melanocyte stimulating hormone. Mouse E(+)/E(+) melanocytes, but not e/e or E(so)/E(so) melanocytes, respond to agouti signaling protein with decreased basal tyrosinase activity, and reduction in levels of tyrosinase and tyrosinase-related proteins 1 and 2. Only in E(+)/E(+) melanocytes does agouti signaling protein abrogate the stimulatory effects of (alpha)-melanocyte stimulating hormone on cAMP formation and tyrosinase activity. These results indicate that a functional melanocortin 1 receptor is obligatory for the response of mammalian melanocytes to agouti signaling protein.
Identification of a tyrosinasse from a periphytic marine bacterium (1990)

A newly isolated periphytic marine bacterium has been shown to synthesize a true tyrosinase. The enzyme exhibited both cresolase and catecholase functions and catalyzed the biosynthesis of melanin from l-tyrosine. Enzyme activity was enhanced in the presence of oxidants and was inhibited by copper chelating agents such as diethyldithiocarbamic acid and cyanide. The apparent molecular weigth of the 2–40 tyrosinase (67 000) makes this enzyme the largest known procaryote tyrosinase.
Homelessness Research - the Office of Housing Perspective (2007)

Research is critical to ensuring the Office of Housing (OoH) policy and programs are fully informed and responsive to the needs of those who experience homelessness. A strong and robust body of research on homelessness is of great benefit to all stakeholders in the response to homelessness in Victoria.
Kinetics of Protein-Nucleic Acid Interactions: Use of Salt Effects to Probe Mechanisms of Interactio (1986)

The kinetics of protein-nucleic acid interactions are discussed with particular emphasis on the effects of salt concentration and valence on the observed rate constants. A general review is given of the use of experimentally determined salt dependences of observed kinetic parameters as a tool to probe the mechanism of interaction. Quantitative analysis of these salt dependences, through the application of polyelectrolyte theory, can be used to distinguish reactions which occur in a single step from those reactions which involve distinct intermediates. For those rate constants which display a large salt dependence, in either the association or dissociation reaction, this is due to the high concentration of counterions (e.g., Na+) in the vicinity of the nucleic acid which are subsequently released (or bound in the case of dissociation) at some point before the rate limiting step of the reaction. A general discussion of other features which affect protein-nucleic acid kinetics, such as nucleic acid length and the ratio of nonspecific to specific DNA binding sites (in the case of sequence specific binding proteins), is also given. The available data on the nucleic acid binding kinetics of small ligands (ions, dyes, oligopeptides), nonspecific binding proteins (T4 gene 32 protein, fd gene 5 and Escherichia coli SSB), and sequence specific binding proteins (lac repressor, RNA polymerase, Eco RI restriction endonuclease) are discussed with emphasis on the interpretation of the experimentally determined salt dependences.
The role of cordless communications in PCS (2002)

PCS is often identified with mobile/cellular systems, e.g. DCS1800 (sometimes referred to as PCN, it is a standard for GSM on 1800 MHz). Personal Communications Systems aiming for a broad subscriber basis must however comprise many systems (existing and future). As cordless system provides very high capacity (DECT /spl ap/ 10,000 Erlang/km//sup 2/floor), they are likely to be considerable part of PCS. Advanced cordless systems as DECT (Digital European Cordless Telecommunications) are easy to adapt to and integrate with other systems as ISDN, GSM, PSTN etc. This paper describes the main features and applications of DECT and the concept of "profiles" in DECT facilitating a deep integration with other systems.
Models of Muscle Pain: Carrageenan Model and Acidic Saline Model (2004)

Carrageenan or acidic saline injected unilaterally into the gastrocnemius muscle or triceps muscle produces a robust and long-lasting hyperalgesia in rats and mice, which is reversible with systemic administration of opioid or anti-inflammatory drugs. This unit describes detailed protocols for inducing and measuring hyperalgesia, and provides information on validation of these models. These models are useful for assessing new compounds for their analgesic activity in muscular pain.
Aqueous Solubility Prediction Based on Weighted Atom Type Counts and Solvent Accessible Surface Areas (2009)

In this work, four reliable aqueous solubility models, ASM-ATC (aqueous solubility model based on atom type counts), ASM-ATC-LOGP (aqueous solubility model based on atom type counts and ClogP as an additional descriptor), ASM-SAS (aqueous solubility model based on solvent accessible surface areas), and ASM-SAS-LOGP (aqueous solubility model based on solvent accessible surface areas and ClogP as an additional descriptor), have been developed for a diverse data set of 3664 compounds. All four models were extensively validated by various cross-validation tests, and encouraging predictability was achieved. ASM-ATC-LOGP, the best model, achieves leave-one-out correlation coefficient square (q2) and root-mean-square error (RMSE) of 0.832 and 0.840 logarithm unit, respectively. In a 10,000 times 85/15 cross-validation test, this model achieves the mean of q2 and RMSE being 0.832 and 0.841 logarithm unit, respectively. We believe that those robust models can serve as an important rule in druglikeness analysis and an efficient filter in prioritizing compound libraries prior to high throughput screenings (HTS).