gebhart/patrepeval huggingface dataset:
Characterization of Distinct Angiotensin II Binding Sites in Rat Adrenal Gland and Bovine Cerebellum Using Selective Nonpeptide Antagonists (1991)

We investigated the characteristics of 125I-AII binding to rat adrenal and bovine cerebellar membranes in the presence and absence of new nonpeptide angiotensin II (All) receptor ligands. The imidazole All ligands, DUP753 and WL19, both produced biphasic competition curves to 125I-All binding in rat adrenal glomerulosa and adrenal medulla particles, suggesting the existence of two distinct All binding sites. Antagonist affinity (Ki) and binding capacity (Bmax) for each binding site was determined using nonlinear analysis of competition data fit to a two-site model. The high capacity site (68% of total specific 125I-All bound) in glomerulosa had high affinity for DUP753 (4.6 ± 0.8 nM) and low affinity for WL19 (29 ± 3 μM), and the low capacity site had high affinity for WL 19 (3.3 ± 1.4 nM) and low affinity for DUP753 (51 ± 9 μM). Conversely, in medulla, the high capacity site (77% total binding) had high affinity for WL 19 (19 ± 6 nM) and low affinity for DUP753 (29 ± 8 μM), and the low capacity site had low affinity for WL19 (25 ± 7 μM) but a high affinity for DUP753 (2.8 ± 2.0 nM). In glomerulosa, binding parameters for the nonpeptide ligands at each site derived from monophasic competition curves obtained in the presence of either 0.3 μM DUP753 or WL 19 to selectively block the high or low capacity binding site, respectively, were similar to values determined from the biphasic competition curves. Unlike the nonpeptide inhibitors, unlabeled All yielded monophasic inhibition curves. WL19 and DUP753 also blocked 125I-All binding to bovine cerebellar membranes (Ki = 0.14 ± 0.03 and 170 ± 21 μM, respectively), and both displayed monophasic competition curves. All-induced contraction of rabbit aorta was potently and competitively blocked by DUP753 (K = 3.9 ± 0.4 nM) but not by WL 19. Thus, the Ki values for DUP753 at the DUP753-sensitive binding site in rat adrenal glomerulosa and medulla are similar to the affinity of DUP753 for All receptors in rabbit aorta, suggesting a similarity among these sites. The Ki values for WL19 at the WL19-sensitive site in rat adrenal gland and bovine cerebellum differ from 7–40-fold and represent binding site(s) distinct from the DUP753-sensitive site.
Lymphocyte Adherence to High Endothelial Venules: Characterization of a Modified <i>in Vitro</i> Assay, and Examination of the Binding of Syngeneic and Allogeneic Lymphocyte Populations (1979)

Abstract Mouse lymphocytes incubated on fresh frozen sections of mesenteric lymph nodes adhere specifically to the endothelium of high endothelial venules (HEV), specialized vessels through which lymphocytes normally enter lymph nodes from the blood. An assay of the specific binding of lymphocytes to HEV in frozen sections is characterized and is used to compare the capacity of various syngeneic and allogeneic lymphocyte populations to adhere to HEV in mouse mesenteric lymph nodes. The relative adherence of lymphocyte populations to HEV in this in vitro system correlates highly with their localization in HEV a) during single-pass perfusion through the lymph node at 37°C, or b) in vivo 15 min after i.v. injection. With this assay we have shown that the binding of mesenteric node lymphocytes (MNL) to syngeneic mesenteric node HEV is constant: no significant variation was observed between individual mice, between sexes, between mice of various ages (3 weeks to 9 months), or after treatment of the lymphocyte donor with hydrocortisone acetate. B lymphocytes adhered as well as T lymphocytes and exhibited no preference for HEV bordering on B areas in the lymph node section. In general, other syngeneic cell populations bind in proportion to their content of mature lymphocytes. MNL exhibited no preferential adherence to syngeneic as opposed to allogeneic HEV, but A/J and BALB/c MNL demonstrated greater binding than C57BL/6J and AKR/Cum MNL, regardless of the HEV donor strain.
A 6 ns 4 Mb ECL I/O BiCMOS SRAM with LV-TTL mask option (2003)

The authors report on a 4-Mb BiCMOS SRAM which achieves 6-ns and 8-ns access times with ECL (emitter coupled logic) and TTL (transistor-transistor logic) I/O interfaces, respectively, using: (1) a BinMOS converter directly connecting the ECL level to the CMOS level, (2) a high-speed BinMOS circuit with low-threshold voltage nMOSFETs, (3) an optimum word decoder, and (4) high-speed bipolar sensing circuits with a 3.3-V supply. The SRAM is applicable to either an ECL 100 K interface (VCC=0 V, VEE=4.5 V) or an LV-TTL interface (VCC=3.3 V, VEE=0 V), depending on the mask option used.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Cumulative Cisplatin Dose Affects the Long-Term Survival Outcomes of Patients with Nasopharyngeal Carcinoma Receiving Concurrent Chemoradiotherapy (2016)

The prognostic value of the cumulative cisplatin dose (CCD) remains controversial for patients with nasopharyngeal carcinoma (NPC) receiving only concurrent chemoradiotherapy (CCRT). We retrospectively reviewed 549 consecutive patients with non-metastatic, histologically-proven NPC treated using intensity-modulated radiotherapy (IMRT) at Sun Yat-sen university cancer center. Patient survival between different CCD groups were compared. The cut-off value of pre-treatment plasma EBV DNA (pre-DNA) and CCD based on disease-free survival (DFS) were 1460 copies/ml (AUC, 0.691; sensitivity, 0.717; specificity, 0.635) and 240 mg/m(2) (AUC, 0.506; sensitivity, 0.526; specificity, 0.538), respectively. Of the entire cohort, 92/549 (16.8%) patients received a CCD ≥ 240 mg/m(2) and 457 (83.2%) patients, < 240 mg/m(2). For CCD ≥ 240 mg/m(2) vs. < 240 mg/m(2), the estimated 4-year DFS, overall survival (OS), locoregional-free survival (LRFFS) and distant metastasis-free survival (DMFS) rates were 89.1% vs. 81.3% (P = 0.097), 92.4% vs. 90.0% (P = 0.369), 95.6% vs. 91.2% (P = 0.156), and 91.3% vs. 88.4% (P = 0.375), respectively. For the whole cohort, multivariate analysis identified the CCD was an independent prognostic factor for DFS (HR, 0.515; 95% CI, 0.267-0.995; P = 0.048). However, CCD (≥ 240 mg/m(2)) had no prognostic value in subgroup analysis with stratification by the cut-off value of pre-DNA (P > 0.05 for all rates).
PEER EVALUATION MODEL FOR ENHANCING WRITING PERFORMANCE OF STUDENTS WITH LEARNING DISABILITIES (1998)

Cooperative learning and peer coaching are popular vehicles for interactive instructional enrichment and can be fine tuned as a means for peer involvement in the assessment of the written work of classmates with learning disabilities. Factors that influence the outcome of peer participation in the process of authentic assessment are reviewed. Emphasis is placed on enriching the ability of students with learning disabilities to participate in cooperative learning experiences, structuring the peer evaluation process to enhance the input peers can provide their classmates, and identifying writing performance indicators that can be incorporated into an evaluation form that helps students improve their writing skills.
Mechanistic studies of protein fractionation by precipitation with carboxymethyl cellulose (1988)

The properties of aggregates formed by the precipitation of egg white proteins by carboxymethyl cellulose (CMC) were examined. Both the final level and the number of incremental additions of the polyelectrolyte were varied. The protein and lysozyme recoveries, particle zeta potential, and protein composition of the precipitate were found to vary with only the final CMC level. Particle size and size distributions were dependent on both the polymer dosage and manner of addition. Overdosed systems, or systems in which the CMC dosage exceeded that required for optimal total protein removal, produced the smallest particles with size increasing as the number of incremental polymer additions increased. Optimally dosed systems produced the largest particles.
Macromol. Biosci. 4/2007 (2007)

Back Cover: The schematic representation and the scanning electron microscope image of poly(hydroxyethyl methacrylate) microgel particles crosslinked with acetal based crosslinkers. Further details can be found in the article by V. Bulmus, * Y. Chan, Q. Nguyen, and H. L. Tran on page 446.
A fast match for continuous speech recognition using allophonic models (1992)

In a large vocabulary real-time speech recognition system, there is a need for a fast method for selecting a list of candidate words from the vocabulary that match well with a given acoustic input. The authors describe a highly accurate fast acoustic match for continuous speech recognition. The algorithm uses allophonic models and efficient search techniques to select a set of candidate words. The allophonic models are derived by constructing decision trees that query the context in which each phone occurs to arrive at an allophone in a given context. The models for all the words in the vocabulary are arranged in a tree structure and efficient tree search algorithms are used to select a list of candidate words using these models. Using this method, the authors are able to obtain over 99% accuracy in the fast match for a continuous speech recognition task which has a vocabulary of 5000 words.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Oxypropylation of fatty alcohols, and the sulfation products (1966)

Abstract Reaction of propylene oxide, rather than ethylene oxide, with fatty alcohols, gives a higher yield (50%) of mono‐oxyalkylation product because the secondary alcohol formed is less reactive than the primary alcohol formed with ethylene oxide. Rate of further reaction is about half the rate of the parent primary alcohol. Distributuon of propylene oxide reaction products follows the Weibull‐Nycander equation. Analysis of reaction products was accomplished by gas‐liquid chromatography of the acetylated ether alcohol mixtures. Pure mono‐oxypropylated alcohols ROCH 2 CHOHCH 3 and in some cases dioxypropylated alcohols R[OCH 2 CH(CH 3 )] 2 OH were separated by fractional distillation. Individual ether alcohols and products with a known average number of oxypropyl groups were sulfated and evaluated in terms of Krafft point, critical micelle concentration, detergency, foam height and lime soap dispersing properties. Incorporation of one oxypropyl group was more effective than the same degree of oxyethylation, and improved solubility with no significant loss in foaming and detergency. Ether alcohol sulfates from propylene oxide are stable to alkaline hydrolysis and nearly equal to the sulfates from ethylene oxide in their stability to acid hydrolysis.
ChemInform Abstract: Structure and Dynamics of Exchanged Cations in Zeolites as Investigated by Molecular Dynamics and Computer Graphics (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Micro thin-film li-ion battery stacking challenge by backside via last TSV technology (2017)

Telecommunication and sort-range communication will be more expansion by the internet of things. Especially, body area network (BAN) or smart-agriculture solution is able to realize the “Managed-ICT (Information and Communication Technology)” society. However, there are main three technical barriers to make this society. First is ASIC and MEMS staked sensor device fabrication. Second is a new communication protocol, which has power-saving standby, high speed and low-latency transport, and high reliability, is essential. And finally is small stand-alone battery. That is long-lifecycle, high capacity, flexible and secondary battery. The wafer/panel level packaging (WLP/PLP) technology is main solution about fusion (ASIC and MEMS-sensor) device fabrication. And, the method of wireless multi-hop network with event-driven system based on the physical layer of IEEE 802.15.4 is one of the key solutions about problem of communication protocol. This paper will describe the technology development of the process integration to make a small-die of the high-density micro thin-film lithium ion secondary stand-alone battery using by 3D packaging technologies. The thin-film battery (TFB), which structure is Ni / a-Si / LiPON / LiCoO2 / Pt / Ti / Si sub., has been developed by sputtering technology. The highly-accurate “LiPON”, “LiCoO2” and backside TSV etching technologies are necessary to miniaturization and 3D-staked. TSV etching has been developed by “Scallop-free” etching. In this research, a process for stacking functional chips using backside via technology was surveyed, mainly for platform construction of future 3D heterogeneous integration (Figure 1) to realize the “Managed - ICT” applications using by novel high-density packaging technologies.
Association of seed size with genotypic variation in the chemical constituents of soybeans (1995)

Abstract Ten soybean genotypes grown in 1992 with seed size ranging from 7.6 to 30.3 g/100 seeds and maturity group V or VI were selected and tested for oil and protein content and for fatty acid composition. In these germplasm, protein varied from 39.5 to 50.2%, oil, 16.3 to 21.6%, and protein plus oil, 59.7 to 67.5%. Percentages of individual fatty acids relative to total fatty acids varied as follows: palmitic, 11.0 to 12.8; stearic, 3.2 to 4.7; oleic, 17.6 to 24.2; linoleic, 51.1 to 56.3 and linolenic, 6.9 to 10.0. Seed size showed no significant correlations with individual saturated fatty acids, protein or oil content. However, significant correlations were found between seed size and individual unsaturated fatty acids: positive with oleic, and negative with linoleic and linolenic. Oil and protein content were negatively correlated with each other. Among the major fatty acids, only the unsaturated were significantly correlated with each other: negative between oleic and linoleic or linolenic, and positive between linoleic and linolenic. A subsequent study with soybeans grown in 1993 generally confirmed these findings. Variation in relative percentages of unsaturated fatty acids and r values for most pairs of relationships were even higher than those obtained from the 1992 crop.
Pulsed Overload Tolerance of Si/Cr, Ni/Cr and Mo/Si Thin Film Resistors on Integrated Circuits (1976)

The maximum Fusing Voltage (FV) (for 0.1-10 μs pulses) of Mo/Si, Ni/Cr, and Si/Cr resistors formed on oxidized Si substrates has been experimentally shown to be essentially independent of the following parameters: 1) resistive film material, 2) passivation film material (but a crack-free film is important for Ni/Cr resistors) and 3) the thickness of the oxide fim between the resistor and silicon substrate (0.5-1.5 μm). The FV depends on the resistor geometry, substrate material, and post fabrication annealing of the resistors. The most commonly used resistor geometry is adequate for use on ICs. The most dramatic change in FV obtained in the study was for resistors formed on glass substrates. The FV was reduced by almost a factor of 2 for 0.1 μs pulses over that of resistors on Si substrates. Post fabrication annealing resulted in marked increases in FV for each material for the 0.1 μs pulses but had diminishing effects for 1.0 and 10 μs. Annealing for times greater than 60 minutes or temperatures greater than 470° didn't result in important further increases.
Cognitive functioning and brain magnetic resonance imaging in children with sickle Cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease. (1996)

These results substantiate the importance of careful evaluation, educational planning, and medical intervention for CNS-related complications in children with sickle cell disease.
Amino acid substitutions at tryptophan 388 and tryptophan 412 of the HepG2 (Glut1) glucose transporter inhibit transport activity and targeting to the plasma membrane in Xenopus oocytes. (1992)

All 6 tryptophan residues in the human HepG2-type glucose transporter (Glut1) were individually altered by site-directed mutagenesis to investigate the role of these residues in transport function. Tryptophan residues in positions 48, 65, 186, 363, 388, and 412 of Glut1 were changed to either a glycine or leucine residue. Mutant mRNAs were synthesized and injected into Xenopus laevis oocytes. Transporter function as assessed by uptake of 2-deoxy-D-[3H]glucose or transport of 3-O-[3H]methylglucose was decreased in the 388 and 412 mutants but was unaltered in all other mutants. The amount of the mutant transporters expressed in total membrane and plasma membrane fractions was measured using Glut1-specific antibodies. Calculation of the intrinsic transport activity of each of the mutants using these data demonstrated that the reduced transport activity of the 412 mutants was caused entirely by a dramatic decrease in the intrinsic activity of the mutant proteins whereas the reduced activity of the 388 mutants was a result of a decreased level of the protein in oocytes, decreased targeting to the plasma membrane, and a modest decrease in the intrinsic activity. Protease/glycosidase mapping of in vitro translation products indicated that the effects of the 388 and 412 point mutations could not be attributed to a disruption in the ability of the mutant proteins to insert properly into the membrane. The ID50 for cytochalasin B inhibition of 2-deoxyglucose uptake was increased from 5 x 10(-7) M for the wild-type Glut1 to 4 x 10(-6) M in the 388 mutants but was unaltered in the 412 mutants. These observations suggest that 1) Trp-412 may comprise part of a hexose binding site or is involved in maintaining a local tertiary structure critical for transport function; 2) Trp-388 is involved in stabilizing the equilibrium binding of cytochalasin B to the transporter. Trp-388 may therefore lie near a substrate binding site and also appears to participate in stabilization of local tertiary structure important for full catalytic activity and efficient targeting to the Xenopus plasma membrane.
Enabling Collaborative Edge Computing for Software Defined Vehicular Networks (2018)

Edge computing has great potential to address the challenges in mobile vehicular networks by transferring partial storage and computing functions to network edges. However, it is still a challenge to efficiently utilize heterogeneous edge computing architectures and deploy large-scale IoV systems. In this article, we focus on the collaborations among different edge computing anchors and propose a novel collaborative vehicular edge computing framework, called CVEC. Specifically, CVEC can support more scalable vehicular services and applications by both horizontal and vertical collaborations. Furthermore, we discuss the architecture, principle, mechanisms, special cases, and potential technical enablers to support the CVEC. Finally, we present some research challenges as well as future research directions.
Collaborative Work with Volumetric Data Using Augmented Reality (2002)

The augmented reality videoconferencing system is a novel remote collaboration tool combining a desktop-based AR system and a videoconferencing module. The novelty of our system is the combination of these tools i.e. superimposing AR applications on live video background displaying the conference parties' real environment, thus merging the advantages of videoconferencing (natural face-to-face communication) and AR (interaction with distributed virtual objects using tangible physical artifacts). We demonstrate the system's collaborative features with a volume rendering application that allows users to display and examine volumetric data simultaneously and to highlight or explore slices of the volume by manipulating an optical marker as a cutting plane interaction device.
The outer membrane as the penetration barrier against mupirocin in Gram-negative enteric bacteria (1992)

Journal Article The outer membrane as the penetration barrier against mupirocin in Gram-negative enteric bacteria Get access MARTTI VAARA MARTTI VAARA Department of Bacteriology and Immunology, University of HelsinkiHaartmaninatu 3,00290 Helsinki. Finland Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 29, Issue 2, February 1992, Pages 221–222, https://doi.org/10.1093/jac/29.2.221 Published: 01 February 1992
Randomized resonators as uniquely identifiable anti-counterfeiting tags (2008)

We discuss how LC circuits with randomized properties can be used as anti-counterfeiting tags. Work in progress is presented. Test circuits made using thin film technology easily achieve 20 to 3 bits of identification capacity. We describe our experimental setup, the radiofrequent response curves, and the stable features that can be extracted from them.
Modular Checkpointing for Atomicity (2007)

Transient faults that arise in large-scale software systems can often be repaired by re-executing the code in which they occur. Ascribing a meaningful semantics for safe re-execution in multi-threaded code is not obvious, however. For a thread to correctly re-execute a region of code, it must ensure that all other threads which have witnessed its unwanted effects within that region are also reverted to a meaningful earlier state. If not done properly, data inconsistencies and other undesirable behavior may result. However, automatically determining what constitutes a consistent global checkpoint is not straightforward since thread interactions are a dynamic property of the program. In this paper, we present a safe and efficient checkpointing mechanism for Concurrent ML (CML) that can be used to recover from transient faults. We introduce a new linguistic abstraction called stabilizers that permits the specification of per-thread monitors and the restoration of globally consistent checkpoints. Global states are computed through lightweight monitoring of communication events among threads (e.g. message-passing operations or updates to shared variables). Our checkpointing abstraction provides atomicity and isolation guarantees during state restoration ensuring restored global states are safe. Our experimental results on several realistic, multithreaded, server-style CML applications, including a web server and a windowing toolkit, show that the overheads to use stabilizers are small, and lead us to conclude that they are a viable mechanism for defining safe checkpoints in concurrent functional programs. Our experiments conclude with a case study illustrating how to build open nested transactions from our checkpointing mechanism.
System of Centromeric, Episomal, and Integrative Vectors Based on Drug Resistance Markers for <i>SacCharomyces Cerevisiae</i> (2006)

Integrative, centromeric, and episomal plasmids are essential for easy, fast, and reliable genetic manipulation of yeast. We constructed a system of shuttle vectors based on the widely used plasmids of the pRS series. We used genes conferring resistance to Geneticin (kanMX4), nourseothricin (natNT2), and hygromycin B (hphNT1) as markers. The centromeric and episomal plasmids that we constructed can be used the same way as the traditional auxotrophic marker-based shuttle vectors (pRS41x and pRS42x series). Additionally, we created a set of nine yeast integrative vectors with the three dominant markers. These plasmids allow for direct integration in the LEU2, URA3, and HIS3 locus of any yeast strain and the concomitant partial deletion of the gene. This prevents multiple integrations and allows for the rapid identification of correct integrants. The set of new vectors considerably enhances the flexibility of genetic manipulations and gene expression in yeast. Most notably, the new vectors allow one to work with natural yeast isolates, which do not contain auxotrophic markers.