gebhart/patrepeval huggingface dataset:
Rapid, Regioselective Living Ring‐Opening Metathesis Polymerization of Bio‐Derivable Asymmetric Tricyclic Oxanorbornenes (2018)

The synthesis of a range of alkyl esters (methyl, n-butyl, and n-decyl) prepared via Steglich esterification of the thermodynamically controlled exo, exo Diels-Alder adduct of furfuryl alcohol and maleic anhydride is reported. Subsequent ring-opening metathesis polymerization of these bio-derivable tricyclic oxanorbornene analogs delivers polymers with targeted molar mass and low molar mass dispersity. The polymerizations are rapid with complete monomer conversion achieved within 15 min. Significantly, the presence of the cyclic lactone at the bridgehead of these monomers leads to polymers with high regioregularity (>85% head-to-tail) and high stereoregularity (>75% trans). The resultant polymers display both high thermal stability and high glass transition temperatures. This new class of oxanorbornene monomer, accessed from bio-derivable furfuryl alcohol and maleic anhydride, may be further tailored to incorporate a range of functional moieties. Furthermore, the exceptional properties of the derived polymers indicate potential in a range of applications.
Emerging Analytical Techniques for Rapid Pathogen Identification and Susceptibility Testing (2019)

In the face of looming threats from multi-drug resistant microorganisms, there is a growing need for technologies that will enable rapid identification and drug susceptibility profiling of these pathogens in health care settings. In particular, recent progress in microfluidics and nucleic acid amplification is pushing the boundaries of timescale for diagnosing bacterial infections. With a diverse range of techniques and parallel developments in the field of analytical chemistry, an integrative perspective is needed to understand the significance of these developments. This review examines the scope of new developments in assay technologies grouped by key enabling domains of research. First, we examine recent development in nucleic acid amplification assays for rapid identification and drug susceptibility testing in bacterial infections. Next, we examine advances in microfluidics that facilitate acceleration of diagnostic assays via integration and scale. Lastly, recentdevelopments in biosensor technologies are reviewed. We conclude this review with perspectives on the use of emerging concepts to develop paradigm-changing assays.
Spherulitic Crystallization Behavior of Poly(ε-caprolactone) with a Wide Range of Molecular Weight (1997)

Poly(ε-caprolactone) (PCL) with a wide range of molecular weight (MW) has been prepared via fractionation by either precipitating PCL/chloroform solutions into different amounts of methanol or adding methanol into PCL/tetrahydrofuran (THF) solutions. The samples with Mn ranging from 1900 to 64 700 were used to investigate the MW effects on the spherulite growth rate, nucleation density, and equilibrium melting point (Tm0) of PCL. The variation of spherulite growth rate with MW exhibited a maximum rather than a conventional monotonic drop. The existence of such a maximum was rationalized by considering the interplay between the effects of MW on Tm0 and segmental mobility. A growth kinetic formula proposed by Hoffman was employed to extract the crystal surface free energy product (σσe). In contrast to the conventional Lauritzen−Hoffman analysis which was based on the growth rates measured at different crystallization temperatures (Tc) for a given MW, the present analysis was based on the growth rates measured for different MW at a given Tc. The spherulite nucleation density was found to be higher for the sample with larger MW, and this observation was interpreted based on the individual effects of MW on the primary nucleation rate and spherulite growth rate. An increase in MW promoted the nucleation rate much more significantly compared with its effect on the growth rate, and this in turn led to a higher nucleation density. An unusual morphology due to the segregation of uncrystallizable short chains into the interfibrillar regions of the spherulites was also observed for PCL with Mn = 1900.
Toxicity of Pine Monoterpenes to Mountain Pine Beetle (2017)

The mountain pine beetle (Dendroctonus ponderosae; MPB) is an eruptive bark beetle species affecting pine forests of western North America. MPB are exposed to volatile monoterpenes, which are important host defense chemicals. We assessed the toxicity of the ten most abundant monoterpenes of lodgepole pine (Pinus contorta), a major host in the current MPB epidemic, against adult MPB from two locations in British Columbia, Canada. Monoterpenes were tested as individual volatiles and included (-)-β-phellandrene, (+)-3-carene, myrcene, terpinolene, and both enantiomers of α-pinene, β-pinene and limonene. Dose-mortality experiments identified (-)-limonene as the most toxic (LC<sub>50</sub>: 32 μL/L), and (-)-α-pinene (LC<sub>50</sub>: 290 μL/L) and terpinolene (LC<sub>50</sub>: >500 μL/L) as the least toxic. MPB body weight had a significant positive effect on the ability to survive most monoterpene volatiles, while sex did not have a significant effect with most monoterpenes. This study helps to quantitatively define the effects of individual monoterpenes towards MPB mortality, which is critical when assessing the variable monoterpene chemical defense profiles of its host species.
Linking named entities in Tweets with knowledge base via user interest modeling (2013)

Twitter has become an increasingly important source of information, with more than 400 million tweets posted per day. The task to link the named entity mentions detected from tweets with the corresponding real world entities in the knowledge base is called tweet entity linking. This task is of practical importance and can facilitate many different tasks, such as personalized recommendation and user interest discovery. The tweet entity linking task is challenging due to the noisy, short, and informal nature of tweets. Previous methods focus on linking entities in Web documents, and largely rely on the context around the entity mention and the topical coherence between entities in the document. However, these methods cannot be effectively applied to the tweet entity linking task due to the insufficient context information contained in a tweet. In this paper, we propose KAURI, a graph-based framework to collectively link all the named entity mentions in all tweets posted by a user via modeling the user's topics of interest. Our assumption is that each user has an underlying topic interest distribution over various named entities. KAURI integrates the intra-tweet local information with the inter-tweet user interest information into a unified graph-based framework. We extensively evaluated the performance of KAURI over manually annotated tweet corpus, and the experimental results show that KAURI significantly outperforms the baseline methods in terms of accuracy, and KAURI is efficient and scales well to tweet stream.
<i>Cdx2</i> is essential for axial elongation in mouse development (2004)

Inactivation of Cdx2 leads to preimplantation embryonic lethality. Rescue of the implantation defect by tetraploid fusion established that Cdx2 is necessary for trophoblastic development, vasculogenesis in the yolk sac mesoderm, allantoic growth, and chorioallantoic fusion. "Rescued" Cdx2 mutants die at late gastrulation stages because of failure of placental development. Cdx2 is also needed for the completion of the normal process of gastrulation and tail bud elongation. Presegmental paraxial mesoderm is severely restricted in amount and somites posterior to somite 5 are abnormal. The Cdx2 mutation, like mutations impairing Wnt and Fgf signaling, causes posterior truncations and disturbs axial patterning of the embryonic structures, indicated by changes in the Hox expression domains. The gene appears to be important in the integration of the pathways controlling embryonic axial elongation, and anterior-posterior patterning.
Immunohistochemistry of a prostate membrane specific protein during development and maturation of the human prostate (1997)

An antiserum against secretory vesicles from human seminal fluid (prostasomes) was used to study the localisation and distribution of the respective antigen(s) during prenatal development and pubertal maturation of the human prostate. The crude antiserum stained both secretory and membrane proteins in the adult prostate and other glands, such as pancreas and parotid gland. An immunoaffinity purified fraction from the antiserum selectively reacted with the apical plasma membrane of prostatic epithelium adluminal cells, recognizing a 100 kDa antigen (PMS). Even in the earliest stages of embryonic prostate specimens studied, the adluminal plasma membrane of the epithelial cells from developing glandular anlagen reacted strongly. The occurrence of PMS immunoreactivity in prostatic anlagen was directly correlated with lumen formation. As the antigen is an androgen-independently synthesised membrane protein of the prostate, it may possibly be used as a marker of cell polarity in the normal and pathologically altered prostate.
Air Conditioning System Sizing for Pure Electric Vehicle (2015)

Emission standards have grown increasingly stricter, consequently triggering greater interest in issues surrounding environmental pollution. The customer needs for green car without toxic exhaust gas has also become natural and it is represented by pure EV (Electric Vehicle). However, the driving range of EV suffers from A/C (Air Conditioning) for occupant comfort especially in very hot or cold weather. Therefore, the sizing of A/C system is more important than the case of conventional internal combustion engine vehicle. Specifically, EV consumes electric power of battery pack in order to control the comfortability of passenger compartment due to not only the absence of engine heat rejection for interior heating, but no working power of compressor from engine for interior cooling. Therefore, energy consumption for cabin cooling/heating must be optimized for the energy efficiency of EV. In this paper, we concentrate on the refrigerating system sizing because indoor air temperature in hot weather is more sensitive to passenger’s thermal comfort.
Mechanism of Formation of Carbonyl Iron Electrodes in Alkaline Batteries (2012)

Abstract not Available.
Assignment of the human skeletal muscle α-tropomyosin gene (TPM1) to band 15q22 by fluorescence in situ hybridization (1995)

A sequence-tagged site (STS) was developed for the human skeletal muscle alpha-tropomyosin gene (TPM1) and used to isolate a genomic clone, lambda TPM1.1, containing part of the TPM1 gene. Fluorescence in situ hybridization of this clone to metaphase chromosome spreads localised TPM1 to chromosome band 15q22. This localisation in humans is consistent with that recently described for the mouse.
Mild cognitive impairment (2003)

Mild cognitive impairment is not an established diagnosis but a concept for which different criteria have been proposed and modified over time. Mild cognitive impairment refers to the transitional zone between normal ageing and dementia. The mild cognitive impairment stage may be one of the optimum stages at which to intervene with preventive therapies. The heterogeneity of the term has been recognized. Multiple sources of heterogeneity have been described for mild cognitive impairment, including biological factors, clinical symptoms and clinical course. It is still not possible to consider mild cognitive impairment as an explicit predictor of Alzheimer's disease with the current criteria. The heterogeneity within mild cognitive impairment has been noted, and a classification has been proposed: amnestic or single memory mild cognitive impairment, multiple domains mild cognitive impairment, and single non-memory mild cognitive impairment. Future research should be focussed on redefining the criteria of the mild cognitive impairment entity. This could enable the better development of appropriate therapeutic interventions.
Measurement of antibody to Jo-1 by ELISA and comparison to enzyme inhibitory activity. (1987)

Antibody to the Jo-1 antigen (histidyl-tRNA synthetase) is found almost exclusively in myositis patients, usually those with adult PM, but has been found in only 30% of that group by immunodiffusion or other techniques thus far reported. We have reexamined the prevalence of antibody to Jo-1 in sera from 130 patients and 82 controls by using the sensitive ELISA technique. The ELISA used affinity-purified, enzymatically active bovine Jo-1 antigen. A wide range of antibody level by ELISA was found among 24 immunodiffusion positive sera. Six myositis and two control sera had apparent specific antibody detectable only by ELISA. Overall, however, the antibody continued to show high myositis specificity with predominance in adult PM (35.8% in that group). Because the antibody inhibits enzymatic activity of the synthetase antigen, we also studied the quantitative inhibitory activity of these sera to compare with the antibody activity as determined by ELISA. Twenty-four immunodiffusion-positive sera, 29 immunodiffusion-negative sera, and 15 normal sera were tested at 1/50 dilution in the reaction mixture. There was background inhibition by all normal sera tested that averaged 30.5%. All but one immunodiffusion negative myositis sera (a high binder by ELISA) inhibited less than 50% of the average with normal serum. Twenty-three of 24 immunodiffusion positive sera inhibited greater than 80% of this normal average; the other inhibited 66%. The serum dilution giving 50% inhibition was highly correlated (R = 0.83) with the ELISA activity. Thus, inhibition of histidyl-tRNA synthetase activity is a relatively accurate measure of Jo-1 antibody. This method should be applicable to measuring antibody to other aminoacyl-tRNA synthetases.
Combined Attacks and Countermeasures (2010)

Logical attacks on smart cards have been used for many years, but their attack potential is hindered by the processes used by issuers to verify the validity of code, in particular bytecode verification. More recently, the idea has emerged to combine logical attacks with a physical attack, in order to evade bytecode verification. We present practical work done recently on this topic, as well as some countermeasures that can be put in place against such attacks, and how they can be evaluated by security laboratories.
Multivariate Analysis on Fruit Morphological Characteristics and Estimation on Selection Effect of Selected Individuals of Sorbus alnifolia (Sieb. et Zucc.) K. Koch (2014)

본 연구는 팥배나무의 열매에 대한 우수개체 선발을 위한 기초자료를 얻고자 11개 집단에서 총 107개체를 선발하여 선발목 열매의 형태적 특성 변이를 조사하고 주성분 분석과 군집분석을 실시하였으며 열매 특성에 의한 선발효과를 추정하였다. 주성분 분석 결과, 제4 주성분까지 75.4%의 설명력을 나타냈으며 군집분석에서는 4 그룹으로 구분되어짐을 알 수 있었다. 열매 수확량과 관련된 특성인 열매 폭과 길이 그리고 송이 당 수확량 특성을 대상으로 광교산1, 2와 덕유산7 그리고 마니산 29, 30 등 5개체의 우수개체 후보목을 선발하였다. 선발개체 5본에 대해서 전체 평균 형질과 비교하여 선발효과를 추정한 결과, 열매 폭은 122.8%, 열매 길이는 115.5%, 송이 당 수확량은 182.7%의 선발효과를 추정할 수 있었다. In order to select superior trees based on fruit characteristics and provide basic informations necessary for their improvement, total 107 individual trees of Sorbus alnifolia (Sieb. et Zucc.) K. Koch were selected from 11 wild populations in South Korea. After collecting normal fruit branch, we investigated morphological characteristics of fruit and then considered its relationship among the 11 populations by multivariate analysis method. Results from principal compound analysis showed that it represented 85.8% accumulated explanation from five principal compounds. According to cluster analysis based on fruit characteristics, the natural S. alnifolia populations were classified into four groups and Mt. Mani population was different from other populations. Selection effect with outstanding candidate trees including superior 5 individual trees (Gwangyo 1, Gwangyo 2, Deogyu 7, Mani 29, Mani 30) was estimated at 122.8%, 115.5% and 182.7% in fruit width, length and yield per fruit bunch, respectively. The object of this results will give us invaluable information about breeding by selection of S. alnifolia in south Korea.
Granulomatous Peritonitis Due to Cellulose Fibers From Disposable Surgical Fabrics:Laboratory Investigation and Clinical Implications (1974)

Two patients with postoperative granulomatous peritonitis were found to have lesions with a distinctive type of foreign body. Laboratory investigation revealed this foreign body to be cellulose, morphologically identical with fibers derived from disposable surgical gowns and drapes, and cotton. The same type of foreign body granulomas was produced experimentally by introducing lint prepared from these gowns and drapes into the peritoneal cavities of rats. Since disposable gowns and drapes are being used with increasing frequency, cellulose lint derived from these sources should be added to the list of hazardous foreign materials which are potential wound contaminants.
Angiotensin II Inhibits Cortical Cholinergic Function (1990)

In the present studies we have shown that angiotensin II (AT II), in a concentration-dependent manner in rat tissue (10(-9)-10(-5) M) or at a single concentration in human tissue (10(-6) M), can inhibit potassium-stimulated release of [3H]acetylcholine ( [3H]Ach) from slices of rat entorhinal cortex and human temporal cortex preloaded with [3H]choline for the biochemical analyses. The inhibitory effects of AT II (10(-6) M) were antagonised by the specific AT II receptor antagonist [1-sarcosine, 8-threonine]AT II in a concentration-dependent manner in rat tissue (10(-11)-10(-8) M) and at the single concentration employed in the human studies (10(-7) M). Also demonstrated were other components of the angiotensin system in the human temporal cortex; ACE activity was present (1.03 nmol min-1 mg-1 protein), as were AT II recognition sites (Bmax = 8.6 fmol mg-1 protein). It is hypothesised that the potential cognitive enhancing properties of ACE inhibitors may reflect their action to prevent the formation of AT II and so remove an inhibitory modulator of cholinergic function.
COMPULSIVE FEATURES IN A PATIENT WITH LEBER'S DISEASE (1939)

ALTHOUGH reports of cases of Leber's disease (hereditary optic atrophy) have been published by British, French, and German authors, very few such reports are to be found in the American literature. The unusual findings of neurotic manifestations of a compulsive nature in a female patient with this disease appears to justify their presentation.
Packaging Glass with a Hierarchically Nanostructured Surface: A Universal Method to Achieve Self-Cleaning Omnidirectional Solar Cells (2015)

Fused-silica packaging glass fabricated with a hierarchical structure by integrating small (ultrathin nanorods) and large (honeycomb nanowalls) structures was demonstrated with exceptional light-harvesting solar performance, which is attributed to the subwavelength feature of the nanorods and an efficient scattering ability of the honeycomb nanowalls. Si solar cells covered with the hierarchically structured packaging glass exhibit enhanced conversion efficiency by 5.2% at normal incidence, and the enhancement went up to 46% at the incident angle of 60°. The hierarchical structured packaging glass shows excellent self-cleaning characteristics: 98.8% of the efficiency is maintained after 6 weeks of outdoor exposure, indicating that the nanostructured surface effectively repels polluting dust/particles. The presented self-cleaning omnidirectional light-harvesting design using the hierarchical structured packaging glass is a potential universal scheme for practical solar applications.
Multimedia multicast in mobile computing (2002)

With rapid technological advances being made in the area of wireless communications it is expected that, in the near future, mobile users will be able to access a wide variety of services such as multicast distribution of multimedia streams. These services are characterized by the integrated processing of different media types, such as audio and video. Different multimedia streams must be played out in a synchronized way. However, due to the asynchronous nature of the communication (packets or radio), some problems can disrupt the synchronization such as delay jitter. We present a synchronization protocol for multicast streams. It allows a mobile host to playback continuously a multimedia stream. When a mobile host moves from cell to cell, the scheme allows non-stop playback. The mechanism used is based on the pre-buffering of media units. We present a computation of the handoff time and a mechanism for the restoration of the initial buffer size. Simulation results show that, when resources are already reserved, the handoff time is bounded and the buffer takes again its initial size.
Iron, Copper, and Zinc Concentrations in Normal Skin and in Various Nonmalignant and Malignant Lesions (1986)

The concentrations of zinc (Zn), copper (Cu), and iron (Fe) in the skin have been noninvasively determined in vivo by diagnostic x-ray spectrometry. The skin of healthy controls was divided into two major groups based upon the distribution of the concentrations of these elements. In the face and upper neck, the following wet weight concentrations were recorded: Fe, 14.2 +/- 3.3 ppm; Cu, 1.3 +/- 0.3 ppm; and Zn, 6.7 +/- 1.1 ppm. In the chest, abdomen, arm, axilla, and lower neck, the concentrations of these elements were as follows: Fe, 10.2 +/- 2.5 ppm; Cu, 0.8 +/- 0.3 ppm; and Zn, 4.5 +/- 1.7 ppm. In most lesions of solar dermatitis, solar keratosis, basal and squamous cell carcinomas, variable elevations of Zn and Fe (up to significant levels) were recorded in most of the contralateral, apparently uninvolved skin. In the majority of pigmented nevi and malignant melanomas, the levels of Fe and Zn were elevated. In some of these, the Cu concentration also was increased.
Surface roughness effects on the terahertz reflectance of pure explosive materials (2008)

We studied the effect of surface roughness on terahertz reflectance spectra of explosives at both quasinormal and oblique incidence by Fourier-transform spectroscopy. The optical constants of 1,3,5,7-tetranitro-1,3,5,7-tetrazacyclooctane and 1,3,5 trinitro-1,3,5 triazacyclohexane were determined from the reflectance spectra of pure optically flat pellets and clear spectral signatures were found in the 0.5–8THz range. In the case of a realistic surface roughness of several tens of microns, the observation of the spectral signatures at quasinormal incidence is hindered by the specular reflectance roll-off at terahertz frequencies. On increasing the angle of incidence, the roll-off occurred at higher frequency and the surface roughness was optically measured. Oblique incidence geometries can benefit the development of terahertz standoff detection devices.
Numerical Analysis And Experimental Validation Of A Downhole Stress/Strain Measurement Tool (2013)

Real-time measurement of applied forces, like tension, compression, torsion, and bending moment, identifies the transferred energies being applied to the bottomhole assembly (BHA). These forces are highly detrimental to measurement/logging-while-drilling tools and downhole equipment. Real-time measurement of the dynamic downhole behavior, including weight, torque, bending on bit, and vibration, establishes a real-time feedback loop between the downhole drilling system and drilling team at the surface. This paper describes the numerical analysis of the strain data acquired by the measurement tool at different locations on the strain pockets. The strain values obtained by FEA for various loading conditions (tension, compression, torque, and bending moment) are compared against experimental results obtained from an identical experimental setup. Numerical analyses results agree with experimental data within 8% and, therefore, substantiate and validate the FEA model. This FEA model can be used to analyze the combined loading conditions that reflect the actual drilling environment.