gebhart/patrepeval huggingface dataset:
The future of saphenous vein as a coronary artery bypass conduit (1989)

Continuing widespread use of autologous saphenous vein for coronary artery bypass grafting seems unavoidable despite its poor-term patency. We review here the evidence that platelet activation is responsible for early and late vein graft occlusion and conclude that other mechanisms probably contribute to late occlusions. We suggest that a rational strategy to improve vein graft patency should include: improved endothelial preservation during surgical implantation; use of better antiplatelet agents, in particular those which prevent platelet adhesion as well as aggregation; reduction of risk factors including serum cholesterol; and application of agents (e.g. heparin) which inhibit smooth muscle cell proliferation directly. We draw parallels between the pathogenesis of vein graft occlusion and coronary atherosclerosis and suggest that testing strategies for improving vein graft patency may also shed light on atherogenesis.
Role of Protein Aggregation in Neurodegenerative Diseases (2013)

Proteins and peptides are essential complex macromolecules of organisms and participate in actually every process within cells. Three dimensional structures of proteins play a critical role for biological functions. Therefore, they must be properly folded for performing these functions. Three dimensional structures are determined by composition of amino acid se‐ quence. In addition to hydrophobic forces, covalent and weak interactions direct the forma‐ tion of native protein conformation [1].
Effect of concurrent administration of aspirin and indomethacin on serum concentrations (1974)

Because of a suggested interaction between salicylates and indomethacin, 6 healthy volunteers were given salicylate by mouth and indomethacin by rectum at different intervals. Serum concentrations were determined. The results show that the serum concentrations of salicylate and indomethacin are independent of their concurrent administration and presence in the serum.
Hepatic Expression of Hepatitis B Virus Genome in Chronic Hepatitis B Virus Infection (1996)

The expression of hepatitis B virus (HBV) DNA in the liver was studied by nonisotopic in situ hybridization and correlated with liver histology, different phases in the natural evolution of chronic hepatitis B, and hepatic expression of HBV antigens in 251 Chinese patients with chronic HBV infection. A good correlation was found between the detection of HBV-DNA by in situ hybridization and serum HBV-DNA (P < .01). Chronic active hepatitis had the highest HBV-DNA detected in cytoplasm and nuclei, compared with livers showing minimal change, chronic persistent hepatitis, cirrhosis, and hepatocellular carcinoma. HBV-DNA in cytoplasm exceeded HBV-DNA in nucleus in all patients except in livers with hepatocellular carcinoma. Hepatic HBV-DNA correlated with disease activity (P < .02) and the correlation was highly significant with intralobular activity (P < .001). Patients in the early viral replicative phase of infection had higher levels of cytoplasmic and nuclear HBV-DNA compared with the late viral nonreplicative phase. Cytoplasmic and nuclear HBV-DNA correlated with hepatic expression of HBcAg and HBsAg (P < .05 in both cases), but not with HBeAg. These data indicate that hepatic expression of HBV-DNA follows the natural history of chronic HBV infection and is associated with active liver disease.
Say What? The Activity of the Polyamine Biosynthesis Inhibitor Difluoromethylornithine in Chemoprevention Is a Result of Reduced Thymidine Pools? (2013)

In this issue of Cancer Discovery, Witherspoon and colleagues use an unbiased metabolite profiling approach to study the effects of polyamine depletion by 2-difluoromethylornithine in colon cancer cells. Their surprising findings indicate that it is a decrease in thymidine pools resulting from altered tetrahydrofolate availability rather than decreases in polyamines that produces cytostasis.
Efficient organic light-emitting diodes through up-conversion from triplet to singlet excited states of exciplexes (2012)

Enhanced electroluminescence efficiency is achieved in organic light-emitting diodes through delayed fluorescence of the exciplex state formed between 4,4′,4′′-tris[3-methylphenyl(phenyl)amino]-triphenylamine (m-MTDATA) as an electron-donating material and 2,8-bis(diphenylphosphoryl)dibenzo-[b,d]thiophene (PPT) as an electron-accepting material. The devices exhibited maximum external electroluminescence quantum and power efficiencies of 10.0% and 47.0 lm/W, respectively.
<i>p</i>-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTp-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical StructureCorwin. Hansch and Toshio. FujitaCite this: J. Am. Chem. Soc. 1964, 86, 8, 1616–1626Publication Date (Print):April 1, 1964Publication History Published online1 May 2002Published inissue 1 April 1964https://pubs.acs.org/doi/10.1021/ja01062a035https://doi.org/10.1021/ja01062a035research-articleACS PublicationsRequest reuse permissionsArticle Views4630Altmetric-Citations1842LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Robocasting of biomimetic hydroxyapatite scaffolds using self-setting inks (2014)

Low temperature self-setting ceramic inks have been scarcely investigated for solid freeform fabrication processes. This work deals with the robocasting of alpha-tricalcium phosphate/gelatine reactive slurries as a bioinspired self-setting ink for the production of biomimetic hydroxyapatite/gelatine scaffolds. A controlled and totally interconnected pore network of ∼300 μm was obtained after ink printing and setting, with the struts consisting of a micro/nanoporous matrix of needle-shaped calcium deficient hydroxyapatite crystals, with a high specific surface area. Gelatine was effectively retained by chemical crosslinking. The setting reaction of the ink resulted in a significant increase of both the elastic modulus and the compressive strength of the scaffolds, which were within the range of the human trabecular bone. In addition to delaying the onset of the setting reaction, thus providing enough time for printing, gelatine provided the viscoelastic properties to the strands to support their own weight, and additionally enhanced mesenchymal stem cell adhesion and proliferation on the surface of the scaffold. Altogether this new processing approach opens good perspectives for the design of hydroxyapatite scaffolds for bone tissue engineering with enhanced reactivity and resorption rate.
Klotho, the long sought-after elixir and a novel tumor suppressor? (2006)

No abstract available.
Super continuum generation at 800 nm in highly nonlinear photonic crystal fibers with normal dispersion (2002)

More than 90 nm broad self-phase modulation (SPM) induced pulses have been created from both 25 and 50 fs pulses in just 12.5 cm of fiber. The broadening is more than 2.5 times that observed in standard SMF. SPM broadening in PCFs has several advantages over more complex super continuum generation (SCG) effects in fibers with zero or positive dispersion at the pumping wavelength. The output is very stable, there is no loss of power to unwanted wavelengths and the spectral shape is relatively insensitive to fluctuations in pumping power. This also makes the output suitable for subsequent compression, for 10 fs-range pulse generation. By shifting the zero-dispersion and pumping wavelength to the telecom range, WDM sources become a potential application.
Multi-reflected enhancement of fourth harmonic DUV laser generation at 266 nm (2010)

The stable compact operation in the deep ultraviolet laser at 266 nm is reported from a diode-end-pumped acoustic-optic Q-switched Nd:YVO4/KTP/BBO laser. Fourth harmonic is generated by employing multiple reflections of 532 nm light for taking full advantage of the green beam. An ultraviolet laser at 266 nm with average power of 388.5 mW is obtained with a repetition-rate of 20 kHz, a pulse width of about 59.80 ns, and the corresponding optical to optical conversion efficiency of 11.9% from green to UV. High conversion efficiency and a circular spot of 266 nm laser beam have been achieved in an unfocused beam arrangement.
A DirectFET based high-frequency fuel-cell inverter (2009)

In this paper, the design guideline for a high-power-density inverter for fuel-cell applications is presented. Such an inverter can lead to savings in volume and weight due to high-frequency operation. Also, we present a guideline to determine the optimal size of the input filter. It is also illustrated that, for such a topology, an optimal choice of transformer leakage inductance is necessary to achieve low power loss and to establish a balance between efficiency and reliability. Transient load condition, which may degrade fuel-cell-stack reliability, is handled through a battery-sourced energy-buffering unit. Experimental results demonstrating the nominal operations of inverter and energy buffering unit are presented.
A 75-Year-Old Man With Congestive Heart Failure (1999)

DR DELBANCO: Mr C is a 75-year-old retired fisherman who came to the United States from the West Indies more than 10 years ago. He and his wife live in Boston, Mass, with their daughter, who has been an important source of support for him. He has Medicare and supplemental commercial insurance.
TRIHEXYPHENIDYL (1949)

This paper relates the experience of my colleagues and myself using the new antispasmodic compound trihexyphenidyl (artane,® 3-[1-piperidy1]-1-pheny1-1-cyclohexy1-1-propano1 hydrochloride 1 ) in the treatment of parkinsonism and several of the related disorders of movement. trial of a new treatment of an old disease calls to mind a recent statement of A. C. Ivy, 2 who commented, The physician practices medicine today, and because the response of different patients to the same therapy will always vary to some extent, the physician will always practice medicine on his patient. No physician can honestly guarantee that he will cure a disease or that his treatment will not cause undesirable symptoms or temporary discomfort. Faced with the present lack of knowledge regarding the specific cause of parkinsonism, spasmodic torticollis, blepharospasm and other of the disabling disorders of movement, what should be the physician's therapeutic goal? In the belief that each of the diseases forming
DISCOVERY AND CONTRACTING OF SEMANTIC WEB SERVICES (2005)

The automatic location of services that fulfill a given need is recognized as a key step towards dynamic and scalable integration. In order to achieve such automation, a model that considers the dynamic aspects of service provision and how they affect service descriptions, and that enables an efficient and accurate discovery and contracting of relevant services, is required. In this paper we propose such a model, paying special attention to the distinction between services and Web services and how these two concepts relate to each other. The border between Web service discovery and service contracting is discussed, and what kind of descriptions can be expected at each step is analyzed. We outline requirements on frameworks for semantic description of Web Services in the light of our model, and propose techniques for realizing the dicovery and contracting steps.
The Design and Use of Sensitive Pressure-Jump Sensors to Detect Thunderstorm Gust Fronts. Part I : Pressure- Jump Detector Design (1977)

Abstract We outline the known properties of atmospheric pressure jumps, including rise-time and pressure-amplitude statistics, and we indicate how these statistics guide the choice of pressure-jump detector components.We review design considerations and test procedures and discuss the practical constraints of inside and outside installations of such detectors. Our tentative conclusion is that a pressure switch with a threshold of 0.5mb, used with a high-pass filter with about a 3 min time constant, can detect sudden pressure increases reliably. The final choice of components and the evaluation of the sensor for thunderstorm gust-front detectionwill depend upon the accumulation of operating experience under well-defined meteorological conditions.
On ‘Spinal cord stimulation for chronic, intractable pain: superiority of ‘multi-channel’ devices’ by North et al., in Pain (1991) 119–130 (1991)

Department of Anaesthesia, Section Pain Clinic, University Hospital, 9000 GentBelgium ∗Correspondence to: Dr. Jacques Devulder, Department of Anaesthesia, Section Pain Clinic, University Hospital, De Pintelaan 185, 9000 Gent, Belgium. Submitted March 6, 1991; accepted May 8, 1991.
Influence of a Cell-Wall-Associated Protease on Production of α-Amylase by <i>Bacillus subtilis</i> (1998)

AmyL, an extracellular alpha-amylase from Bacillus licheniformis, is resistant to extracellular proteases secreted by Bacillus subtilis during growth. Nevertheless, when AmyL is produced and secreted by B. subtilis, it is subject to considerable cell-associated proteolysis. Cell-wall-bound proteins CWBP52 and CWBP23 are the processed products of the B. subtilis wprA gene. Although no activity has been ascribed to CWBP23, CWBP52 exhibits serine protease activity. Using a strain encoding an inducible wprA gene, we show that a product of wprA, most likely CWBP52, is involved in the posttranslocational stability of AmyL. A construct in which wprA is not expressed exhibits an increased yield of alpha-amylase. The potential role of wprA in protein secretion is discussed, together with implications for the use of B. subtilis and related bacteria as hosts for the secretion of heterologous proteins.
A Bray-Curtis Weighted Automaton for Detecting Malicious Code Through System-Call Analysis (2009)

Malicious code detection is one of the top subjects of interest for intrusion detection systems in today's computer security research areas. In this paper we propose a new heuristic method for detecting malicious code through system call matching, which also takes in consideration the time of the system call, by using an adaptive search for an extended Aho-Corasick automaton supporting a subset of the regular expressions language, through the use of a normalization technique known as the Bray-Curtis (Sorensen) distance. We will also discuss how this technique can be applied to enrich the set of existing rules from the knowledge base for improving the detection rate.
Application of the Ion Microprobe Mass Analyzer to Problems in Steels (1974)

Application of secondary ion analysis to iron and steel was investigated by using the ion microprobe mass analyzer. The spatial distribution of light elements was examined. The methods of various sample preparation were compared, and the surface polished with Al2O3 powder was found to be most suitable for in-depth analysis. This technique was applied to analysis of surface segregation of Al in Fe-0.1%Al alloys. In low alloy steels, it was found that the chemical composition of the sample could be determined with good accuracy by measuring the relative ion intensity ratios.
Formation of Embedded Monocrystalline NiSi<sub>2</sub> Grid Layers in Silicon by MBE (1984)

Overgrowth of monocrystalline silicon films has been achieved by the molecular beam epitaxy technique on patterned NiSi 2 layers which were epitaxially grown on Si(111) substrates. The embedded NiSi 2 grid layer can be used as the gate in a permeable base transistor and can form buried electrodes in other novel devices.
TIVO-3: A phase III, randomized, controlled, multicenter, open-label study to compare tivozanib to sorafenib in subjects with refractory advanced renal cell carcinoma (RCC). (2019)

541 Background: Tivozanib (T) is a biochemically potent and highly selective VEGF tyrosine kinase receptor inhibitor in clinical development in RCC. The TIVO-1 trial in treatment naïve or prior cytokine-treated subjects with metastatic (m) RCC showed a median progression free survival (mPFS) of 11.9 months (mos) for T compared to 9.1 mos for sorafenib (S) (p = 0.042, HR = 0.797). However, overall survival (OS) favored sorafenib, likely due to imbalanced crossover to active treatments. TIVO-3 was conducted to confirm the PFS results from TIVO-1. Methods: Subjects with mRCC who failed 2 or 3 prior systemic regimens, one of which included a VEGFR TKI other than S or T, were stratified by IMDC risk category and type of prior therapy (two TKIs; TKI plus checkpoint; TKI + other) then randomized in a 1:1 ratio to T or S. The primary objective was to compare PFS by blinded independent radiological review. 350 subjects were enrolled to yield 244 events with ~88% power to detect a difference of 6 mos vs. 4 mos with a two-sided p-value of 0.05 by the log-rank test. Secondary endpoints were OS, safety, objective response rate (ORR), and duration of response. Results: The two arms were well balanced for demographics and prior cancer history.60% of subjects had 2 prior lines of therapy and 40% had 3 prior lines. 28% had prior treatment with a checkpoint inhibitor. T demonstrated a statistically significant improvement in mPFS compared to S, 5.6 (95% CI 7.3-5.3) v. 3.9 mos (95% CI 5.6-3.7; HR 0.73; p=0.02). PFS rate at 2 years was 18% for T compared to 5% for S. ORR was 18% for T compared to 8% for S. 44% of T treated subjects experienced a grade 3 treatment-related adverse event compared to 55% for S. Subjects on T were less likely to require a dose reduction (24% v. 38%), interruption (48% v. 63%), or discontinuation (21% v. 29%) due to an adverse event than subjects on S. Conclusions: T is superior to S as measured by PFS; 2-year PFS, and ORR in this pre-treated population and is better tolerated than S. OS data will be updated prior to presentation. Clinical trial information: NCT02627963.
Cloned, Random Chromosomal Sequences as Probes to Identify Salmonella Species (1986)

We have developed and evaluated a new technique--chromosomal probe fingerprinting--to differentiate between strains of Salmonella species by using sequences of cloned chromosomal DNA as probes to highlight restriction site heterogeneity. Chromosomal probe fingerprint patterns were compared with other strain-typing methods and epidemiological data. Seventeen isolates of Salmonella typhimurium recovered from 11 outbreaks had six unique chromosomal probe fingerprint patterns. Most strains of Salmonella dublin, including some that had identical plasmid profiles and restriction endonuclease analysis patterns, could be distinguished by this method. On the other hand, eight of nine isolates of Salmonella enteritidis had a common chromosomal probe fingerprint pattern, although there were differences in plasmid profiles and the isolates had been collected over a lengthy time interval from widely disparate geographic locations. These results suggest clonal dissemination of some Salmonella serovars.
High-reflectivity HfO_2/SiO_2 ultraviolet mirrors (2002)

High-reflectivity dense multilayer coatings were produced for the ultraviolet spectral region. Thin-film single layers and UV mirrors were deposited by ion plating and plasma ion-assisted deposition high-energetic technologies. Optical characterizations of HfO2 and SiO2 single layers are made. The optical constants obtained for these two materials are presented. HfO2 and SiO2 mirrors with a reflectance of approximately 99% near 250 nm are reported.
Providing polyurethane foams with functionality: a kinetic comparison of different “click” and coupling reaction pathways (2012)

For high-tech applications, polyurethane (PU) materials require additional surface properties and functionality, which can be achieved by incorporation of “clickable” groups in the PU structure, allowing for polymer post-modification via chemical coupling with desired molecules. Therefore, in this study, various “click” and coupling reactions, consisting of the copper(I) catalyzed Huisgen 1,3-dipolar alkyne–azide, thermally and photo-initiated thiol–ene/thiol–yne and Diels–Alder reactions, have been used for surface functionalization of PU foams. As a result of diffusional effects, the reaction rate was considerably depressed and thus, the reaction parameters, including the temperature and the concentration of reagents and the “click” compound, were optimized for each click/coupling approach to obtain high functionalization yields. As such, a kinetic comparison study of the different chemistries used was performed, using in situ FT-IR and offline 1H NMR methods. This work not only reveals kinetic trends but also compares promising and limiting aspects of the different click/coupling pathways employed, which is envisaged to be also useful for functionalizing other cross-linked polymeric materials.
The C-terminal end of R-Ras contains a focal adhesion targeting signal (2003)

R-Ras promotes cell adhesion and activation of integrins through a process that is yet unknown. We show here that active R-Ras (38V) promotes the formation of focal adhesions and a spread cell shape. By contrast, the dominant-negative mutant of R-Ras (43N) reduces the number of focal adhesions, leading to the formation of refractile cells. In adherent cells wild-type R-Ras, activated (38V) R-Ras and endogeous R-Ras were preferentially targeted to focal adhesions, whereas the dominant-negative mutant (43N) of R-Ras was excluded from these structures. Activated mutants of H-Ras and K-Ras were not found in focal adhesions. We dissected R-Ras to find out the determinants that are important for the targeting process. The outermost region in the N-terminus of R-Ras, as well as the intact proline-rich sequence in the C-terminus of RRas that mediates binding to Nck, were not essential. Mutating the potential palmitoylation site (C213A) of RRas results in depalmitoylation and accumulation of R-Ras in the Golgi. Using H-Ras/R-Ras, R-Ras/H-Ras and RRas/K-Ras hybrid molecules we showed that the C-termini (175-218 amino acids) of R-Ras contains the signal for focal adhesions targeting. Exchanging the hypervariable region of H-Ras to R-Ras inhibited the targeting of R-Ras to focal adhesions, whereas H-Ras obtained the ability to localize to focal adhesions after receiving the hypervariable region of R-Ras. This indicates that R-Ras targeting is mediated both by the nucleotide binding status as well as through a specific region in the C-terminus of R-Ras. These results indicate that targeting and activation of R-Ras are linked processes in the formation of focal adhesions.