gebhart/patrepeval huggingface dataset:
Endoproteolytic processing of C-terminally truncated NF-κB2 precursors at κB-containing promoters (2007)

The C-terminal, partially truncated forms of the NF-kappaB2/p52 precursor p100, p100DeltaCs, manifest constitutive processing and oncogenic ability, although the responsible mechanisms remain unknown. Here, we report that p100DeltaCs are specifically processed in association with binding to promoter DNA-containing kappaB sites. In the nucleus, p100DeltaCs bind to the kappaB promoter DNA and subsequently recruit the proteasome to form a stable proteasome/p100DeltaC/DNA complex, which mediates the processing of p100DeltaCs. Notably, the processing at the kappaB promoter is initiated by a proteasome-mediated endoproteolytic cleavage at amino acid D(415) of p100DeltaCs, and the processed p52, but not the precursors themselves, is oncogenic by up-regulating a subset of target genes. Our studies demonstrate a different mechanism of p100 processing and also present evidence showing that the proteasome modulates the action of transcription factors at promoter regions through endoproteolysis.
Simultaneous Genotyping and Species Identification Using Hybridization Pattern Recognition Analysis of Generic <i>Mycobacterium </i>DNA Arrays (1998)

High-density oligonucleotide arrays can be used to rapidly examine large amounts of DNA sequence in a high throughput manner. An array designed to determine the specific nucleotide sequence of 705 bp of the rpoB gene of Mycobacterium tuberculosis accurately detected rifampin resistance associated with mutations of 44 clinical isolates of M. tuberculosis. The nucleotide sequence diversity in 121 Mycobacterial isolates (comprised of 10 species) was examined by both conventional dideoxynucleotide sequencing of the rpoB and 16S genes and by analysis of the rpoB oligonucleotide array hybridization patterns. Species identification for each of the isolates was similar irrespective of whether 16S sequence, rpoB sequence, or the pattern of rpoB hybridization was used. However, for several species, the number of alleles in the 16S and rpoB gene sequences provided discordant estimates of the genetic diversity within a species. In addition to confirming the array's intended utility for sequencing the region of M. tuberculosis that confers rifampin resistance, this work demonstrates that this array can identify the species of nontuberculous Mycobacteria. This demonstrates the general point that DNA microarrays that sequence important genomic regions (such as drug resistance or pathogenicity islands) can simultaneously identify species and provide some insight into the organism's population structure.
Liquid Crystalline Primary Benzamides (1994)

Abstract Several alkoxybenzamides are synthesized and characterized by spectroscopic and chromatographic methods. 3,4,5-Tris(alkoxy)benzamides have been found to exhibit a mesophase of a columnar or stack-like type.
On the Potential of Intent-based Access Control (IBAC) in Preventing Insider Threats (2015)

Existing access control mechanisms are based on the concepts of identity enrollment and recognition, and assume that recognized identity is synonymous with ethical actions. However, statistics over the years show that the most severe security breaches have been the results of trusted, authorized, and identified users who turned into malicious insiders. Therefore, demand exists for designing prevention mechanisms. A non-identity-based authentication measure that is based on the intent of the access request might serve that demand. \nIn this thesis, we test the possibility of detecting intention of access using involuntary electroencephalogram (EEG) reactions to visual stimuli. This method takes advantage of the robustness of the Concealed Information Test to detect intentions. Next, we test the possibility of detecting motivation of access, as motivation level corresponds directly to the likelihood of intent execution level. Subsequently, we propose and design Intent-based Access Control (IBAC), a non-identity-based access control system that assesses the risk associated with the detected intentions and motivation levels. We then study the potential of IBAC in denying access to authorized individuals who have malicious plans to commit maleficent acts. Based on the access risk and the accepted threshold established by the asset owners, the system decides whether to grant or deny access requests. \nWe assessed the intent detection component of the IBAC system using experiments on 30 participants and achieved accuracy of 100% using Nearest Neighbor and SVM classifiers. Further, we assessed the motivation detection component of the IBAC system. Results show different levels of motivation between hesitation-based vs. motivation-based intentions. Finally, the potential of IBAC in preventing insider threats by calculating the risk of access using intentions and motivation levels as per the experiments shows access risk that is different between unmotivated and motivated groups. These results demonstrate the potential of IBAC in detecting and preventing malicious insiders.
Image contrast immersion method for measuring refractive index applied to spider silks (2011)

A technique for measuring the refractive index of micron sized fibers using a series of immersion index matching oils, and image contrast measurements is proposed and demonstrated. It has been applied to radial silks of the orb web weaving spider Plebs eburnus. These have widths of ~1-2 microns. Values about 1.5500 are obtained, with birefringence values between 0.0000 and 0.0133 for individual silks. An uncertainty in the range ± 5 × 10(-4) to ± 2 × 10(-3) is achieved for these challenging samples. This accuracy is about a twenty times improvement on previously reported measurements for spider silks using other techniques. The technique is used to obtain measurements of the refractive index of spider silks as a function of wavelength, for the first time. An Abbe number for the radial silks of Plebs eburnus of ~32 is found.
Femtosecond laser-guided electric discharge in air (2000)

Summary form only given. We have studied a new type of electric discharge triggered in air by intense femtosecond IR laser pulses. When propagating in atmosphere, such pulses self-organize in the form of filaments, leaving in their wake a thin plasma column with uniform density along the axis. This plasma column can act as a trigger for electric discharges. The discharge occurs under reduced applied voltage and follows the path of the self-guided laser pulse. Its onset is reproducible, but occurs with a measurable delay. This is to be contrasted with the typical discharge initiated by a non-uniform laser-produced plasma, for which the onset of the discharge fluctuates considerably from shot to shot.
Advances in the Spectral Index Method for the Analysis of Photonic Integrated Circuits (2002)

The prolific rate at which advances in photonics have been made in recent years has increased the need for accurate and efficient computer aided design tools. New device technologies and material systems mean the designer is faced with many more degrees of freedom with which to optimise a design. Because of this versatile techniques that yield results accurately and quickly are foremost in the designers mind. \n\nThroughout this work a well proven technique, the Spectral Index (SI) method is extended and generalised to a wide variety design situations of practical importance. \n\nThe design of a novel Silicon Germanium based device was used to prove the suitability of an iterative design methodology in developing and optimising practical waveguiding components. The novel development of the SI method for the accurate analysis of waveguide losses is then presented further extending its suitability to the analysis and design of rectangular rib waveguides. Following this the generalisation of the SI method to structures of non-rectangular cross-section is presented allowing for the analysis of a wider range of optical rib waveguides. \n\nA novel implementation of the SI method is then developed for the analysis of the whispering gallery class of resonant modes supported by cylindrical dielectric disc and ring structures, allowing for the characterisation of the optical properties of this important class of devices. \n\nA 3D circuit analysis technique based upon a robust implementation of the SI method in its complex form is developed that allows for the characterisation of any waveguide system that may be represented by a number of discrete waveguide components. Finally the SI method is generalised to the full 3D exact analysis of optical waveguiding structures
Inductively shunted transmon qubit with tunable transverse and longitudinal coupling (2017)

We present the design of an inductively shunted transmon qubit with flux-tunable coupling to an embedded harmonic mode. This circuit construction offers the possibility to flux-choose between pure transverse and pure longitudinal coupling, that is, coupling to the ${\ensuremath{\sigma}}_{x}$ or ${\ensuremath{\sigma}}_{z}$ degree of freedom of the qubit. While transverse coupling is the coupling type that is most commonly used for superconducting qubits, the inherently different longitudinal coupling has some remarkable advantages both for readout and for the scalability of a circuit. Being able to choose between both kinds of coupling in the same circuit provides the flexibility to use one for coupling to the next qubit and one for readout, or vice versa. We provide a detailed analysis of the system's behavior using realistic parameters, along with a proposal for the physical implementation of a prototype device.
EFFECTIVENESS OF SALICYLAMIDE AS AN ANALGESIC AND ANTIRHEUMATIC AGENT (1955)

In view of the interest shown salicylamide for its analgesic and antirheumatic effect, it was thought advisable to study both of these under conditions that would lead to statistical evaluation with placebo and other salicylate therapy. Ichniowski and Hueper<sup>1</sup>found that in rats salicylamide, upon oral and intraperitoneal administration, exerts a slightly quicker and deeper depressing effect than aspirin. Hart<sup>2</sup>noted that the relative analgesic potencies in animals for aspirin and salicylamide were 1 and 7 respectively. Hart also noted that, in a group of 118 patients with arthritis treated with 2 gm. of salicylamide every four to eight hours, satisfactory relief was obtained in 75% of the subjects, but 22% had some untoward reaction. Studies of clinical results with salicylamide, available principally in European literature,<sup>3</sup>favored salicylamide over aspirin. It was noted, however, that large doses of salicylamide are required and that the action of the
A Multi-Task Deep Network for Person Re-Identification (2017)

Person re-identification (ReID) focuses on identifying people across different scenes in video surveillance, which is usually formulated as a binary classification task or a ranking task in current person ReID approaches. In this paper, we take both tasks into account and propose a multi-task deep network (MTDnet) that makes use of their own advantages and jointly optimize the two tasks simultaneously for person ReID. To the best of our knowledge, we are the first to integrate both tasks in one network to solve the person ReID. We show that our proposed architecture significantly boosts the performance. Furthermore, deep architecture in general requires a sufficient dataset for training, which is usually not met in person ReID. To cope with this situation, we further extend the MTDnet and propose a cross-domain architecture that is capable of using an auxiliary set to assist training on small target sets. In the experiments, our approach outperforms most of existing person ReID algorithms on representative datasets including CUHK03, CUHK01, VIPeR, iLIDS and PRID2011, which clearly demonstrates the effectiveness of the proposed approach.
Performance analysis of a multi-code CDM transmission scheme based on cyclic extended spread code as a extension of 3rd generation CDMA system (2002)

This paper proposes an adaptive multi-code CDM transmission scheme for the multipath fading environment to achieve high code utilization efficiency. In the proposed system, we apply a new parallel transmission scheme using cyclic codes generated from a modified M-sequence which inserts the guard chips before and after an M-sequence. Moreover with radio channel estimation results obtained from the downlink by this multi-code CDM transmission scheme, the number of guard chips is varied adaptively on the uplink. In a micro cellular system, the performances of the proposed system are evaluated by computer simulation. As a result, it is essential for high quality broadband mobile communications to apply adaptive transmission to the new multi-code CDM transmission system.
Lasing Effect in GeSn Photonic Crystal (2018)

A photonic crystal membrane was fabricated on a GeSn 16% layer, grown on a step-graded buffer structure. The single mode lasing observed at low temperature under optical pumping was attributed to a guided band edge mode of the photonic crystal.
The comparison of different reconstructive methods of alimentary canal for total gastrectomy (2001)

Objective To compare the clinical effects of different reconstructive alimentary canal for total gastrectomy. Methods The patients were divided into P loop/Roux-en-Y and Kuroyangai/ Roux-en-Y groups. The nutritional status of these two groups was investigated. Results The differences of body weight, hemoglobin and total albumin before and after operation in P loop group were (5.65±2.3 ) kg, (2.14±1.6) g/L and (0.95±0.7) g/L; Meanwhile those in Kuroyangai group were(4.29±1.6) kg, (1.10±0.8) g/L and (0.96±0.9) g/L respectively. These differences between two groups were not significant(P＞0.05) . Conclusion Kuroyangai/Roux-en-Y reconstructive alimentary canal for total gastrectomy is a better surgical method.
F-SNP: computationally predicted functional SNPs for disease association studies (2007)

The Functional Single Nucleotide Polymorphism (F-SNP) database integrates information obtained from 16 bioinformatics tools and databases about the functional effects of SNPs. These effects are predicted and indicated at the splicing, transcriptional, translational and post-translational level. As such, the database helps identify and focus on SNPs with potential deleterious effect to human health. In particular, users can retrieve SNPs that disrupt genomic regions known to be functional, including splice sites and transcriptional regulatory regions. Users can also identify non-synonymous SNPs that may have deleterious effects on protein structure or function, interfere with protein translation or impede post-translational modification. A web interface enables easy navigation for obtaining information through multiple starting points and exploration routes (e.g. starting from SNP identifier, genomic region, gene or target disease). The F-SNP database is available at http://compbio.cs.queensu.ca/F-SNP/.
A Neural Schema Architecture for Autonomous Robots (1998)

As autonomous robots become more complex in their behavior, more sophisticated software\narchitectures are required to support the ever more sophisticated robotics software. These\nsoftware architectures must support complex behaviors involving adaptation and learning,\nimplemented, in particular, by neural networks. We present in this paper a neural based schema\n[2] software architecture for the development and execution of autonomous robots in both\nsimulated and real worlds. This architecture has been developed in the context of adaptive\nrobotic agents, ecological robots [6], cooperating and competing with each other in adapting to\ntheir environment. The architecture is the result of integrating a number of development and\nexecution systems: NSL, a neural simulation language; ASL, an abstract schema language; and\nMissionLab, a schema-based mission-oriented simulation and robot system. This work\ncontributes to modeling in Brain Theory (BT) and Cognitive Psychology, with applications in\nDistributed Artificial Intelligence (DAI), Autonomous Agents and Robotics.
Metabolic Signatures Associated with a NAD Synthesis Inhibitor–Induced Tumor Apoptosis Identified by 1H-Decoupled-31P Magnetic Resonance Spectroscopy (2005)

The present results suggest that FK866 interferes with multiple biochemical pathways that contribute to the increased cell death (apoptosis) and subsequent radiation sensitivity observed in the mammary carcinoma that could be serially monitored by 31P MRS.
Narrow-Band Imaging in the Diagnosis of Colorectal Mucosal Lesions: A Pilot Study (2004)

These results suggest that in the examination of colonic lesions the NBI system provides imaging features additional to those of both conventional endoscopy and chromoendoscopy. For distinguishing neoplasms from non-neoplastic lesions, NBI was equivalent to chromoendoscopy.
Structure and Regulation of Calcium/Calmodulin-Dependent Protein Kinases (2001)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and Regulation of Calcium/Calmodulin-Dependent Protein KinasesThomas R. Soderling and James T. StullView Author Information Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 Cite this: Chem. Rev. 2001, 101, 8, 2341–2352Publication Date (Web):July 12, 2001Publication History Received3 January 2001Published online12 July 2001Published inissue 1 August 2001https://doi.org/10.1021/cr0002386Copyright © 2001 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1477Altmetric-Citations155LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (223 KB) Get e-AlertsSUBJECTS:Anatomy,Cell and molecular biology,Monomers,Peptides and proteins,Post-translational modification Get e-Alerts
Characterization of Eu-Doped Y[sub 2]O[sub 3] Nanoparticles Prepared in Nonionic Reverse Microemulsions in Relation to Their Application for Field Emission Display (2000)

luminescent particles were synthesized by the reaction between aqueous yttrium nitrate/europium nitrate salts and ammonium hydroxide solution by bulk precipitation and in the reverse microemulsion composed of NP-5/NP-9, cyclohexane, and water. Compared with luminescent particles formed by the bulk precipitation method, the particles prepared in microemulsion showed a narrower size distribution, spherical shape, smaller size (20-30 nm), higher crystallinity, and stronger photoluminescence. Also, Eu‐doped particles were deposited on the glass plate coated with indium tin oxide through the electrophoretic method. With these glass plates, low‐voltage cathodoluminescence (CL) was measured. The nanoparticles synthesized in reverse micro‐emulsion showed a stronger CL intensity and less current saturation than particles formed by bulk precipitation. These CL properties of particles formed in microemulsion might be attributed to the smaller particle size, the larger luminescent surface area, and more well‐developed crystalline structure of phosphor than those formed by bulk precipitation. © 2000 The Electrochemical Society. All rights reserved.
Representaciones sociales e imaginario social: Aportes para el Trabajo Social Familiar (2017)

Trabajo Fin de Grado en Trabajo Social. Curso 2016/2017. Este ensayo pretende aproximarnos a los conceptos de representaciones sociales e imaginarios sociales reflexionando sobre las aportaciones que estos enfoques teoricos pueden suponer para el Trabajo Social Familiar. En este sentido, se concretan algunas sugerencias y propuestas sustentadas en las conclusiones a las que hemos llegado tras el analisis de los contenidos aludidos.
Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3',4'-f].DELTA.6,8-tetrahydroindolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin (1987)

The resolution of the tricyclic ketone (3a + 3b) by the separation of diastereomeric adducts 4a and 4c of the precursor ketal 5 is described. The regenerated enantiomers 3a and 3b of 100% optical purity represent the key intermediates from which 20(R)-camptothecin (1a) and 20(S)-camptothecin (1b), respectively, have been prepared. The 20R analogue 1a was 10-100 times less active than the natural 20(S)-camptothecin (1b) in 9KB and 9PS cytotoxicity assays and almost inactive in in vivo L-1210 leukemia tests as compared to the highly potent and active natural compound 1b.
Cytotoxic Thiocarbamate Derivatives of Boldine (2010)

Two new boldine derivatives: the 3-thiocarbamateboldine (3) and the 2,9-O,O-diacetyl-3-thiocarbamateboldine (4) have been synthesized and their cytotoxicity evaluated.
Full ALD Al<sub>2</sub>O<sub>3</sub>/ZrO<sub>2</sub>/SiO<sub>2</sub>/ZrO<sub>2</sub>/Al<sub>2</sub>O<sub>3</sub>Stacks for High-Performance MIM Capacitors (2014)

Metal-insulator-metal (MIM) capacitors with full atomic-layer-deposition Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /ZrO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /ZrO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> stacks were explored for the first time. As the incorporated SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> film thickness increased from 0 to 3 nm, the quadratic and linear voltage coefficients of capacitance (α and β) of the MIM capacitors reduced significantly from positive values to negative ones. For the stack with 3-nm SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> film, a capacitance density of 7.40 fF/μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , α of -121 ppm/V <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and β of -116 ppm/V were achieved, together with very low leakage current densities of 3.08 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-8</sup> A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 5 V at room temperature (RT) and 5.89 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-8</sup> A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 3.3 V at 125 °C, high breakdown field of 6.05 MV/cm, and high operating voltage of 6.3 V for a 10-year lifetime at RT. Thus, this type of stacks is a very promising candidate for next generation radio frequency and analog/mixed-signal integrated circuits.