gebhart/patrepeval huggingface dataset:
Resarch into Christ the King Church's archives in Gliwice view of the future development of this church (2009)

Ab s t r a c t The paper is focused on the results of archival research into the history and architecture of Christ the King Church in Gliwice from 1935, derived from the Rectory’s annals and other resources, including photographs of construction works, drawings, designs and the data recorded in the Church’s Chronicle. The Church was designed by an Austrian architect Karl Mayr, whose other works are also mentioned for the sake of comparison. The study also presents earlier concepts of the Church building designed by Dominikus Bohm and includes the analysis of the architectural form of the Church against the background of other sacral buildings constructed in the 1930s and belonging to Austrian and German architectural circles. Possible future developments of the Church are also discussed, especially in view of the students’ competition for the design of a new Church tower imposed by poor technical condition of the present superstructure of the building.
ROOM‐TEMPERATURE FLUORESCENCE PROPERTIES OF THE POLYNUCLEOTIDE POLYdA POLYdT (1991)

The room-temperature fluorescence spectrum of the non-alternating polynucleotide polydA.polydT is found to have its maximum at about 325 nm and, when exciting in the spectral region where both adenine (A) and thymine (T) absorb, to coincide with that obtained for excitation at 293 nm where thymine is selectively excited. The fluorescence anisotropy is found to be equal to 0.18 and independent of the excitation and emission wavelengths. These observations are consistent with: (i) emission stemming from T; and (ii) transfer of electronic energy from A to T being not efficient. These inferences are also supported by the observed dependence of the fluorescence quantum yield on the excitation wavelength.
User-oriented approach to control of tone reproduction for electronic reprographic systems (1992)

Electronic reprographic systems are those which reproduce images through digital means. These systems offer the possibility of more flexible tonal control over pictorial reproduction than earlier analog systems. One challenge of electronic reprographics is to design a method of pictorial tone reproduction control that is simple to operate and that does not require operator knowledge of image processing. Described here is one such method which has been applied to Xerox's DocuTech Production Publisher. All electronic reprographic systems have three major components: a digital scanner, an image processor, and a digital printer. The imaging characteristics of all of these components could be altered to effect the system's tone reproduction. With the described method, scanner and printer imaging characteristics are held rigidly constant through rigorous process controls. This permits direct calculation of image processing characteristics to meet the tone reproduction requirements specified by the customer. The method allows lower cost hardware and faster processing by a reduction in the number of gray levels per pixel. A userfriendly interface and the availability of multiple halftone screens also contribute to meeting customer requirements.
FUNDAMENTALS OF IMMOBILISED YEAST CELLS FOR CONTINUOUS BEER FERMENTATION: A REVIEW (1998)

Recent fundamental research conducted on immobilised cells with a focus on continuous primary beer fermentation is presented in this review. The knowledge of whole-cell immobilisation, continuous fermentation, yeast biochemistry associated with beer flavour production, and bioreactor engineering design is required to apply immobilised yeast cells for industrial scale beer production. Understanding how immobilisation and continuous bioreactor operation affect yeast cell metabolism and viability will provide the groundwork for optimising beer quality. The latest studies on immobilised cell carriers, viability, vitality, mass transfer characteristics and bioreactor design indicate that an industrial scale immobilised cell system for primary beer fermentation may soon be a reality in the modern brewery.
A Cellular FRET-Based Sensor for β-O-GlcNAc, A Dynamic Carbohydrate Modification Involved in Signaling (2006)

beta-O-N-Acetyl-d-glucosamine (O-GlcNAc) is a dynamic carbohydrate modification that is involved in cell signaling and has been implicated in a variety of disease states, including Alzheimer's and type-II diabetes. Despite the importance of this modification, little is known about the spatial and temporal localization of O-GlcNAc during signaling. This is due to the lack of methods for the study of O-GlcNAc in living cell systems. Herein we report the first genetically encoded FRET-based sensor for the detection of O-GlcNAc dynamics in live mammalian cells.
Comprimidos bucodispersables: ventajas terapéuticas y tecnológicas de elaboración (2009)

Orally Disintegrating Tablets are defined as non-coated tablets that are placed in the mouth, where they are rapidly disintegrated before being swallowed. These formulations are known by the acronym FDDT's (Fast Dissolving Disintegrating Tablets). They are useful for
Diabetic Macular Edema: Fundus Autofluorescence and Functional Correlations (2010)

PURPOSE. Diabetic macular edema (DME) shows variable clinical characteristics with unpredictable results to local treatment, probably reflecting different phenotypes. The purpose of this study was to evaluate the role of structural and functional macular imaging in the characterization of DME patterns. METHODS. One hundred fifty-one eyes of 92 diabetic patients with untreated clinically significant macular edema (CSME) underwent best corrected visual acuity (BCVA) determination (logMAR), slit lamp biomicroscopy; fluorescein angiography; optical coherence tomography (OCT; mean central retinal thickness [CRT], volume, and DME pattern); fundus autofluorescence (FAF; absent or increased [i] FAF, single or multiple spots; iFAF area quantification); and microperimetry. Linear correlation, data agreement and three-way analysis of covariance were used for statistics. RESULTS. Thirty-five (23.2%) eyes had normal FAF; and 116 eyes had iFAF: 48 (31.8%) single-spot iFAF, 68 (45%) multiple-spot iFAF. Retinal sensitivity in areas with iFAF was 11.5 +/- 5.3 dB (vs. 15.1 +/- 3.9 dB in normal areas, P < 0.005). Retinal sensitivity of the central field was 15.1 +/- 3.9 dB in normal FAF, 12.4 +/- 4.8 dB in single-spot iFAF and 11.4 +/- 4.9 dB in multiple-spot iFAF (P < 0.05). OCT CRT and volume were not significantly different between the FAF groups. OCT volume correlated to OCT CRT (r = 0.68), retinal sensitivity in iFAF (r = -0.50) and BCVA (r = 0.42). Cystoid OCT pattern and FA edema patterns correlated with iFAF presence (P < 0.0001). CONCLUSIONS. In CSME, FAF correlates better with OCT patterns and central field microperimetry rather than with visual acuity. FAF is a rapid, noninvasive technique that may give new insight into the evaluation of DME. The validity of FAF in the follow-up and treatment outcomes in DME remain to be assessed. (Invest Ophthalmol Vis Sci. 2011;52:442-448) DOI:10.1167/iovs.105588
Distinct Regions of Sp1 Modulate DNA Binding and Transcriptional Activation (1988)

Sp1 is a sequence-specific DNA binding protein that activates RNA polymerase II transcription from promoters that contain properly positioned GC boxes. A series of deletion mutants of Sp1 were expressed in Escherichia coli and used to identify separate regions of the protein that are important for three different biochemical activities. The sequence-specificity of DNA binding was conferred by Zn(II) fingers, whereas a different region of Sp1 appeared to regulate the affinity of DNA binding. The E. coli-synthesized Sp1 was able to stimulate initiation of RNA synthesis in vitro, and at least two distinct segments of the protein contributed to its transcriptional activity.
Immunoelectrophoresis of red blood cells performed on microcapillary chips (2002)

Immunoanalysis of blood cells on a microcapillary electrophoresis (nuCE) chip has been studied using sheep erythrocytes (ShE) as an example. Two different buffer solutions, the phosphate-buffered saline (PBS) and the gelatin veronal buffer (GVB) were examined in regard to the electrokinetic transport behavior of ShE suspended in these solutions inside the rectangular channel engraved on a quartz chip. This clarified two advantages of the use of GVB for on-chip cell electrophoresis: gelatin coatings prevent (i) nonspecific sticking of ShE on the channel wall, and cause (ii) an appreciable reduction in the zeta potential of the wall suppressing the electroosmotic flow of the buffer solution. As a result ShE suspended in the GVB can smoothly migrate from the cathode to the anode, which is the opposite flow direction of immunoglobulin G (IgG) antibodies under the physiological pH condition of 7.4. Based on these results, on-chip capillary cell immunoelectrophoresis of ShE and rabbit anti ShE antibodies (IgG) have been proposed and successfully accomplished using the GVB. It is demonstrated that the variation of the cell migration velocity originating from the change in the surface charge after binding antibodies is applicable to the fast detection of immune reactions and also to single-cell typing.
Finite-length analysis of various low-density parity-check ensembles for the binary erasure channel (2003)

We investigate the average erasure probability of the belief propagation algorithm over the binary erasure channel (BEC) for various finite-length low-density parity-check (LDPC) ensembles. In particular, we give tight upper bounds on the "error floor", i.e., on the contribution to the erasure probability stemming from relatively small deficiencies in the graph. We also define and analyse "expurgated" ensembles and give upper bounds on the error floor of "typical" codes. Finally, we show that typical codes of properly chosen ensembles have an erasure correcting radius which grows linearly in the block length. The presented method provides valuable insight into how finite-length codes should be designed. Although the standard ensemble can achieve capacity on the BEC, the construction of good finite-length codes requires careful control of the structure of the degree two variable nodes. In this paper, we investigate the standard ensemble, the Poisson ensemble, an ensemble in which degree two nodes are added in a cycle, and an ensemble in which different degree two variable nodes have distinct neighboring check nodes.
Local democracy and empowerment of the underpriviledged - an analysis of democratic decentralization in India (2004)

Poverty alleviation efforts are facilitated by democratic decentralization. For a country as big and as diverse as India, anti-poverty programs can become highly problematic unless the elected local government institutions (LGI) participate in their delivery. The crucial importance of the LGIs in the reduction of poverty lies in better targeting of the poor and in providing cost-effective and need-based goods and services at the local level, stimulating growth and thus reduces poverty. There is no guarantee, however, that local democracy will function well in all contexts. It is prone to misuse by powerful sections of the community; it may lack an effective accountability mechanism; and it may provide little space for the poor to participate in local decision-making. In some cases, LGI leaders may not have enough motivation or incentive to accommodate the development needs of vulnerable groups.
Special cantilever geometry for the access of higher oscillation modes in atomic force microscopy (2006)

Employing higher oscillation modes of microcantilevers promises higher sensitivity when applied as sensors, for example, for mass detection or in atomic force microscopy. Introducing a special cantilever geometry, we show that the relation between the resonance frequencies of the first and second resonance modes can be modified to separate them further or to bring them closer together. In atomic force microscopy the latter is of special interest as the photodiode of the beam deflection detection limits the accessible frequency range. Using finite element simulations, we optimized the design of the modified cantilever geometry for a maximum reduction of the frequency of the second oscillation mode with respect to the first mode. Cantilevers were fabricated by silicon micromachining and subsequently utilized in an ultrahigh vacuum Kelvin probe force microscope imaging the surface potential of C60 on graphite.
Measurements on NASA Langley Durable Combustor Rig by TDLAT: Preliminary Results (2013)

Detailed knowledge of the internal structure of high-enthalpy flows can provide valuable insight to the performance of scramjet combustors. Tunable Diode Laser Absorption Spectroscopy (TDLAS) is often employed to measure temperature and species concentration. However, TDLAS is a path-integrated line-of-sight (LOS) measurement, and thus does not produce spatially resolved distributions. Tunable Diode Laser Absorption Tomography (TDLAT) is a non-intrusive measurement technique for determining two-dimensional spatially resolved distributions of temperature and species concentration in high enthalpy flows. TDLAT combines TDLAS with tomographic image reconstruction. Several separate line-of-sight TDLAS measurements are analyzed in order to produce highly resolved temperature and species concentration distributions. Measurements have been collected at the University of Virginia's Supersonic Combustion Facility (UVaSCF) as well as at the NASA Langley Direct-Connect Supersonic Combustion Test Facility (DCSCTF). Measurements collected at the DCSCTF required significant modifications to system hardware and software designs due to its larger measurement area and shorter test duration. Initial LOS measurements from the NASA Langley DCSCTF operating at an equivalence ratio of 0.5 are presented. Results show the capability of TDLAT to adapt to several experimental setups and test parameters.
Estimating the Area Under a Receiver Operating Characteristic Curve For Repeated Measures Design (2003)

The receiver operating characteristic (ROC) curve is widely used for diagnosing as well as for judging the discrimination ability of different statistical models. Although theories about ROC curves have been established and computation methods and computer software are available for cross-sectional design, limited research for estimating ROC curves and their summary statistics has been done for repeated measure designs, which are useful in many applications, such as biological, medical and health services research. Furthermore, there is no published statistical software available that can generate ROC curves and calculate summary statistics of the area under a ROC curve for data from a repeated measures design. Using generalized linear mixed model (GLMM), we estimate the predicted probabilities of the positivity of a disease or condition, and the estimated probability is then used as a bio-marker for constructing the ROC curve and computing the area under the curve. The area under a ROC curve is calculated using the Wilcoxon non-parametric approach by comparing the predicted probability of all discordant pairs of observations. The ROC curve is constructed by plotting a series of pairs of true positive rate (sensitivity) and false positive rate (1- specificity) calculated from varying cuts of positivity escalated by increments of 0.005 in predicted probability. The computation software is written in SAS/IML/MACRO v8 and can be executed in any computer that has a working SAS v8 system with SAS/IML/MACRO.
IEEE P1149 Proposed Standard Testability Bus-An update with case histories (2003)

The author outlines the history of the IEEE P1149 proposed standard testability bus and describes the latest version of the bus, which is now structured to include four distinct subsets (any or all of which may be used in any combination). Included are illustrations of implementations of the proposed bus using circuitry dedicated to the testability bus and also using circuitry that performs both needed circuit functions and the testability interface functions. Built-in test examples are also included. The author concludes with a summary of the time-to-market and economic advantages of using the testability bus and a description of the current status of the P1149 effort plus plans and the timetable for the future.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
<scp>D</scp>‐amino acid residues in peptides and proteins (2003)

We have investigated the D-amino acid residues present in Protein Data Bank (PDB) entries, categorizing them into "real" D-residues and artifacts. In polypeptide chains of more than 20 residues, only a single instance of a "real" D-residue, other than those deliberately designed or engineered, was found. This example was the result of a slow chemical epimerization process. Another 12 designed D-residues were found in these longer polypeptide chains. Smaller peptides of 20 or fewer residues contained 479 "real" D-residues, the majority in various gramicidin, actinomycin, or cyclosporin structures. We found 148 PDB entries with "real" D-residues and a further 186, in which all apparent D-residues are artifacts. Investigating the (phi, psi) preferences of the "real" D-residues, we found that the region around (-60 degrees, -45 degrees ) was almost completely unoccupied, even though it is not formally disallowed. We link the low propensity to occupy this region with the alpha-helix destabilizing properties of D-residues.
An interline transfer CCD imager (1984)

This paper will report on the developmemt of a 492 × 398 element interline transfer CCD imager with a large capacity phOtodiode structure for a single chip 1/2" color camera. The imager has a dynamic range of 75dB.
Solid Supported Chemical Syntheses of Both Components of the Lantibiotic Lacticin 3147 (2011)

Lantibiotics are antimicrobial peptides produced by bacteria. Some are employed for food preservation, whereas others have therapeutic potential due to their activity against organisms resistant to current antibiotics. They are ribosomally synthesized and posttranslationally modified by dehydration of serine and threonine residues followed by attack of thiols of cysteines to form monosulfide lanthionine and methyllanthionine rings, respectively. Chemical synthesis of peptide analogues is a powerful method to verify stereochemistry and access structure-activity relationships. However, solid supported synthesis of lantibiotics has been difficult due to problems in generating lanthionines and methyllanthionines with orthogonal protection and good stereochemical control. We report the solid-phase syntheses of both peptides of a two-component lantibiotic, lacticin 3147. Both successive and interlocking ring systems were synthesized on-resin, thereby providing a general methodology for this family of natural products.
One-Step Synthesis of Highly Luminescent Carbon Dots in Noncoordinating Solvents (2010)

A novel one-step approach for synthesizing highly luminescent oil soluble carbon dots (quantum yield: 53%) and water-soluble carbon dots is introduced. The superior luminescence efficiency, together with the simple, rapid, and reproducible synthesis method will facilitate fundamental studies and promising practical applications of these carbon-based quantum dots.
A method to control the dispersion of carbon black in an immiscible polymer blend (2003)

Abstract The dispersion of carbon black ( CB ) in an immiscible polymer blend of poly‐(methyl methacrylate) (PMMA) and polypropylene (PP) was studied as the viscosity of PMMA increased. It was found that the dispersion of carbon black was strongly influenced by the viscosity of PMMA. The CB was dispersed in the PMMA phase when the viscosities of PMMA and PP are comparable, as predicted by Sumita's model. As the viscosity of PMMA increases, the CB was found to be located at the interface between the PMMA and PP phases. On further increase in the viscosity of PMMA, the CB was found to be dispersed in the PP phase. In addition, the CB dispersion in the PP/PMMA blends can significantly influence the positive temperature coefficient (PTC) intensity of the blends.
Droplet target for laser-produced plasma light sources (2012)

The present work is related to the field of droplet-based laser-produced plasmas (LPP) in soft X-ray and, more specifically, extreme ultraviolet (EUV) sources.EUV sources generate light at 13.5 nm and are employed in EUV lithography, which is the leading candidate to become the semiconductor manufacturing technology for post-193nm immersion lithography.One of the key factors, which limits the operating time of EUV sources, is the generation of tin droplets within the required specifications, such as large droplet spacing, micrometer droplet size and high stability.This work is conducted in the context of the development of a fully functional tin droplet-based high power LPP light source at the Laboratory for Energy Conversion, ETH Zurich.The first objective of this work is to develop, manufacture and assess the performance of a tin droplet dispenser, which is required to generate a monodisperse stream of droplets with frequencies above 10 kHz in the harsh vacuum and plasma environment of an EUV source.Preliminary droplet requirements demand droplet sizes in the range of tens of micrometers, maximized droplet spacings and high temporal and spatial stability with respect to the laser focus.Droplet generation is based
Gene transfer into hematopoietic progenitor and stem cells: Progress and problems (1994)

Gene transfer to hematopoietic cells for the purpose of "gene therapy" is a new and rapidly developing field with clinical trials in progress. A fundamental goal of research in this field is the incorporation of exogenous genes into the chromosomes of the most primitive hematopoietic progenitor cells--stem cells. Recombinantly engineered retroviral vectors are the best characterized and are currently the only vector type in clinical trials directed at the hematopoietic system. High efficiency gene transfer and expression in murine stem cells and their progeny is now routine, but in larger animal models such as dogs or primates and preliminary clinical trials, gene transfer has been less successful. Problems such as retroviral efficiency, gene expression, insertional mutagenesis and helper virus contamination are being addressed. A promising new vector, the adeno-associated virus (AAV), has shown promise and may allow production of high titer, stable, recombinant virions without helper contamination and with potentially better safety parameters. However, the technology for AAV gene transfer is currently underdeveloped, and issues related to the reproducible production of vectors must be addressed. Other non-viral vector systems are being explored, but little data are available on applications to hematopoietic cells. Better preclinical models are needed to study gene targeting and expression in human cells. An overview of recombinant retroviral and adeno-associated viral vector production, preclinical data and preliminary clinical data will be given, and problems needing to be addressed at all stages of development before broad clinical utility can be achieved will be discussed.
Clinical Experience with the Intraparenchymal Intracranial Pressure Monitoring Codman MicroSensor System (2005)

In our hands, the CMS device is reliable and easy to use. The ICP recordings are stable over time, and there is only a minor zero drift. The device is today our standard method for ICP measurements.