gebhart/patrepeval huggingface dataset:
Ontogeny and behaviour of early macrophages in the zebrafish embryo (1999)

In the zebrafish embryo, the only known site of hemopoieisis is an intra-embryonic blood island at the junction between trunk and tail that gives rise to erythroid cells. Using video-enhanced differential interference contrast microscopy, as well as in-situ hybridization for the expression of two new hemopoietic marker genes, draculin and leucocyte-specific plastin, we show that macrophages appear in the embryo at least as early as erythroid cells, but originate from ventro-lateral mesoderm situated at the other end of the embryo, just anterior to the cardiac field. These macrophage precursors migrate to the yolksac, and differentiate. From the yolksac, many invade the mesenchyme of the head, while others join the blood circulation. Apart from phagocytosing apoptotic corpses, these macrophages were observed to engulf and destroy large amounts of bacteria injected intravenously; the macrophages also sensed the presence of bacteria injected into body cavities that are isolated from the blood, migrated into these cavities and eradicated the microorganisms. Moreover, we observed that although only a fraction of the macrophage population goes to the site of infection, the entire population acquires an activated behaviour, similar to that of activated macrophages in mammals. Our results support the notion that in vertebrate embryos, macrophages endowed with proliferative capacity arise early from the hemopoietic lineage through a non-classical, rapid differentiation pathway, which bypasses the monocytic series that is well-documented in adult hemopoietic organs.
H<sub>2x</sub>Mn<sub>x</sub>Sn<sub>3‐x</sub>S<sub>6</sub> (x = 0.11–0.25): A Novel Reusable Sorbent for Highly Specific Mercury Capture Under Extreme pH Conditions (2009)

Abstract The H 2x Mn x Sn 3‐x S 6 (x = 0.11–0.25) is a new solid acid with a layered hydrogen metal sulfide (LHMS). It derives from K 2x Mn x Sn 3–x S 6 (x = 0.5–0.95) (KMS‐1) upon treating it with highly acidic solutions. We demonstrate that LHMS‐1 has enormous affinity for the very soft metal ions such as Hg 2+ and Ag + which occurs via a rapid ion exchange process. The tremendous affinity of LHMS‐1 for Hg 2+ is reflected in very high distribution coefficient K d Hg values (>10 6 mL g −1 ). The large affinity and selectivity of LHMS‐1 for Hg 2+ persists in a very wide pH range (from less than zero to nine) and even in the presence of highly concentrated HCl and HNO 3 acids. LHMS‐1 is significantly more selective for Hg 2+ and Ag + than for the less soft cations Pb 2+ and Cd 2+ . The Hg 2+ ions are immobilized in octahedral sites between the sulfide layers of the materials via Hg–S bonds as suggested by pair distribution function (PDF) analysis. LHMS‐1 could decrease trace concentrations of Hg 2+ (e.g. <100 ppb) to well below the acceptable limits for the drinking water in less than two min. Hg‐laden LHMS‐1 shows a remarkable hydrothermal stability and resistance in 6 M HCl solutions. LHMS‐1 could be regenerated by treating Hg‐loaded samples with 12 M HCl and re‐used without loss of its initial exchange capacity.
A threshold logic full adder based on resonant tunneling transistors (1998)

Resonant tunneling transistors and circuit architectures with enhanced computational functionality are promising candidates for future nano-scale integration. In this paper we propose a full adder cell based on multiple terminal linear threshold gates. The threshold gates are composed of monolithically integrated resonant tunneling diodes and heterostructure field effect transistors. Together with a bit-level pipelining scheme this leads to an efficient implementation with a minimal logic depth of two circuit layers.
Using a model railroad to teach digital process control (1988)

This paper describes experiences with a course designed to introduce undergraduate students to the design and implementation of real-time systems for the monitoring and control of laboratory and industrial processes. A model railroad is suggested as an inexpensive process to control. A variety of laboratory exercises involving such a model railroad are presented.
Contributions for Mandatory Pension Insurance and Legal Regulation of the European Union (2014)

Mirovine predstavljaju jedan od kljucnih segmenata modernog drustva i njegovog pravnog uređenja. Navedena tvrdnja je pogotovo primjenjiva u kontekstu Europe, u kojoj starenje stanovnistva iziskuje sve veca izdvajanja za mirovinske sustave. Iz navedenog razloga, regulacija mirovina, bilo njihove prihodovne, bilo rashodovne strane, predstavlja jedno od najvažnijih podrucja djelatnosti europskih država na pocetku 21. stoljeca. Sukladno tome, države clanice zadržale su primarne nadležnosti za reguliranje doprinosa za obvezno mirovinsko osiguranje u odnosu na Europsku uniju. Ipak, propisi EU u znatnoj mjeri ogranicavaju opisanu autonomiju država clanica u reguliranju ovih doprinosa. Svrha ovog clanka je analizirati regulatornu autonomiju država clanica u podrucju doprinosa za obvezno mirovinsko osiguranje ukljucujuci osnovicu, stopu i obveznike placanja, obveze koje im u tome namece pravna stecevina EU, te ucinak navedenog stanja na obveznike placanja doprinosa. Zakljucak je da situacija u kojoj EU ima vrlo skucene mogucnosti vlastitog regulatornog djelovanja i normiranja sustava socijalne sigurnosti i doprinosa dovodi do nedostatka pravne sigurnosti i jasnoce zakonodavnog procesa na europskoj razini. Ovi nedostaci se ocituju u reguliranju podrucja mirovina i doprinosa na temelju pravnih osnova koje nisu izvorno namijenjene toj funkciji, vec reguliranju određenih drugih podrucja, kao sto je zajednicko tržiste Unije.
Easy and Fast Sensor Fault Detection and Isolation Algorithm for Electrical Drives (2011)

This paper focuses on sensor fault detection and isolation (FDI) for electrical systems. A new, easy and fast FDI algorithm is proposed, keeping system performances unchanged under certain faulty sensor conditions when reconfigurations are available. The proposed FDI algorithm is derived from a parity space approach and is based on temporal redundancies. It is insensitive to parameter variations since no model knowledge is required. Also, it is available for a large class of electrical systems such as single- or three-phase power converters, dc or ac electrical drives, etc. Moreover, the residual threshold used for FDI is accurately defined and is suitable for the whole operating range. Simulations results are presented to illustrate the good functionality of theoretical developments. Numerous experimental results are also shown to validate the effectiveness of the proposed FDI algorithm and to highlight its advantages for the control of electrical systems.
Electrochemistry of quinones (2010)

This chapter contains sections titled: Introduction Half-Wave Potentials Electrochemistry in Non-Aqueous Solvents Electrochemistry in Aqueous Solutions Photoelectrochemistry of Quinones
Pay-Cloak: A Biometric Back Cover for Smartphones (2017)

Continuous improvements in technology and quality of life have had a strong impact on the development of payment techniques. With the evolution of near-field communication (NFC) technology, contactless payment has received recent attention because of its short-range, conducive nature. As mobile computing made great leaps due to enormous development in the smartphone platform, companies like Google, Samsung, and Apple embedded NFC in smartphones to provide on-the-go payment capabilities, eliminating the need for payment cards. But due to interoperability and high cost, these technologies are not available to everyone.
Female Sexual Side Effects Associated with Selective Serotonin Reuptake Inhibitors: A Descriptive Clinical Study of 33 Patients (1995)

With some limitations in interpreting the data, the findings of this study suggest that SSRI-associated female sexual dysfunction occurs at a higher rate than we previously thought, equal potentials in implicating female sexual side effects among three SSRIs, and the absence or the low incidence of female sexual adverse effects from bupropion, and that these side effects can be managed by waiting for a spontaneous remission, dosage reduction of SSRIs, substitution with bupropion and other antidepressants, or the use of an antidote.
Evaluation of <i>Glycine</i> Germplasm for Nulls of the Immunodominant Allergen P34/Gly m Bd 30k (2006)

Soybean [ Glycine max (L.) Merr.] seed contains an immunodominant human allergen P34 or Gly m Bd 30k (mentioned as P34) of the cysteine protease family. of approximately 16 266 accessions from USDA soybean germplasm screened, 12 P34 null lines were identified among soybean ( G. max ), wild annual ( Glycine soja Sieb. and Zucc.), and wild perennial Glycine spp. Glycine soja were low P34 expressers, while G. max and wild perennial species had nondetectable levels of the allergenic protein. Further investigation of G. max nulls by 2D‐IEF/SDS PAGE showed all primary seed proteins present indicating that the loss of P34 was not due to large scale restructuring of protein content. Southern and northern analysis showed no large insertions or deletions to render the gene nonfunctional. The cDNA of both G. max nulls each showed the same six point mutations indicating the two nulls have a single origin. of these six single nucleotide changes, four are predicted to result in an amino acid alteration. One such alteration results in a serine being replaced by a cysteine residue. The introduction of a cysteine residue might produce a mismatched disulfide bond formation producing an unstable P34 protein in the null soybean accessions. The isolation and introgression of soybean lines with low allergen levels will provide the basis for developing a low allergen line incorporated with other agronomically desirable traits in a breeding program.
An auroral model for the NCAR thermospheric general circulation model (TGCM) (1987)

A model of high latitude auroral processes has been developed for use in the NCAR TGCM. The ion drift pattern associated with magnetospheric convection is specified by the empirical model of Heelis et al. (1982) considering offset geographic and geomagnetic poles. An analytic prescription of particle precipitation in the auroral oval is developed that enables rapid numerical evaluation of auroral ionization rates and global aurora power input. An analytic expression has been derived for the total ionization rate and an ion chemical scheme is used to calculate the electron density enhancements and ion density distributions caused by auroral particle precipitation. The results of TGCM runs with and without auroral particle precipitation show the importance of auroral ionization in determining the dynamic structure of the winter hemisphere lower thermosphere.
Chemical Surface Treatment of Alumina, Titania and Talc and Their Surface Natures (1992)

チタネートカップリング剤およびセタノール, シランカップリング剤によるアルミナ, チタニアおよびタルクの表面処理条件, 表面性状が炭素含量, 表面積, 分散性並びに分散嗜好性, 赤外線吸収スペクトルおよび熱分解から検討された。これらの結果から, これらの処理剤はアルミナ, チタニアおよびタルクに対し程度の差はあるがそれぞれ有効に処理されること, 反応はこれら酸化物粉体の表面水酸基がこれら処理剤と脱水または脱アルコール縮合することで進行し, 表面官能基はアルコキシ, オクタデシルジヒドロキシシリル, イソステアロイルチタニル基からなることが認められることおよびタルクの反応に関与する水酸基はSi-O層, Mg-O層に直角な破断側面に形成される水酸甚であることが示唆された。
TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling (2010)

We recently reported that TNFR-associated factor (TRAF)3, a ubiquitously expressed adaptor protein, promotes mature B cell apoptosis. However, the specific function of TRAF3 in T cells has remained unclear. In this article, we report the generation and characterization of T cell-specific TRAF3(-/-) mice, in which the traf3 gene was deleted from thymocytes and T cells. Ablation of TRAF3 in the T cell lineage did not affect CD4 or CD8 T cell populations in secondary lymphoid organs or the numbers or proportions of CD4(+),CD8(+) or double-positive or double-negative thymocytes, except that the T cell-specific TRAF3(-/-) mice had a 2-fold increase in FoxP3(+) T cells. In striking contrast to mice lacking TRAF3 in B cells, the T cell TRAF3-deficient mice exhibited defective IgG1 responses to a T-dependent Ag, as well as impaired T cell-mediated immunity to infection with Listeria monocytogenes. Surprisingly, we found that TRAF3 was recruited to the TCR/CD28 signaling complex upon costimulation and that TCR/CD28-mediated proximal and distal signaling events were compromised by TRAF3 deficiency. These findings provide insights into the roles played by TRAF3 in T cell activation and T cell-mediated immunity.
Src homology 2 domain deletion mutants of p60v-src do not phosphorylate cellular proteins of 120-150 kDa. (1989)

We have constructed seven deletions in the src homology 2 (SH2) domain of the Rous sarcoma virus src gene and have expressed them and wild-type v-src (wt v-src) in Rat 1 fibroblasts. Transfected cells containing mutant DNAs have reduced focus forming activity when compared to cells containing the wt v-src DNA. In most cases, established cell lines that express these mutants have altered growth properties in soft agar. The src proteins isolated from mutant cell lines have reduced tyrosine kinase activity. We also see differences in the phosphorylation of cellular proteins in vivo. Unlike the wt protein kinase, the SH2 domain mutant kinases do not phosphorylate a set of cellular proteins ranging in size from 120-150 kDa.
Poster: Sliding Viewport for Head Mounted Displays in Interactive Environments (2008)

The ability to manipulate objects is fundamental to most virtual reality (VR) applications. A multitude of metaphors have been developed to facilitate object selection and manipulation, including the virtual hand metaphor, which remains by far the most popular technique in this category. The utility of the virtual hand depends on the user's ability to see it. Unfortunately, ensuring this is not always easy, especially in immersive systems which employ head mounted displays (HMD) with limited field of view (FOV), typically ranging from 40 to 60 degrees diagonally.
A Hybrid Adaptive Feedback Based Prefetcher (2009)

We present a hybrid adaptive prefetching scheme in this paper. The scheme consists of a hybrid stride/sequential prefetching mechanism which adapts its aggressiveness based on feedback metrics collected dynamically during program execution. Metrics such as prefetching accuracy and prefetching lateness are used to adjust aggressiveness in terms of prefetch distance (how far ahead of the current miss it fetches) and prefetch degree (the number of prefetches issued). The scheme is applied separately at both the L1 and L2 cache levels. For a set of 15 SPEC CPU 2006 benchmarks, our scheme achieves a geometric mean CPI improvement of 29 % compared to no prefetching and 6 % compared to a stride prefetcher. The performance improvement over a set of memory intensive benchmarks is 45 % over no prefetching and 9 % over stride. 1.
CASCADE: A phase 3, randomized, double-blind study of vadastuximab talirine (33A) versus placebo in combination with azacitidine or decitabine in the treatment of older patients with newly diagnosed acute myeloid leukemia (AML). (2017)

TPS7066 Background: AML is associated with poor survival rates in patients (pts) who are not eligible for intensive chemotherapy or allogeneic stem cell transplant (allo-SCT) due to advanced age, comorbidities, and/or disease risk factors. Non-intensive therapies, such as the hypomethylating agents (HMAs) azacitidine and decitabine, are frequently employed in this setting; however, response rates and survival remain suboptimal in this pt population. Vadastuximab talirine (33A) is a CD33-directed antibody conjugated to pyrrolobenzodiazepine (PBD) dimers. Upon binding, 33A is internalized and transported to the lysosomes where PBD is released via proteolytic cleavage of the linker, leading to DNA crosslinking and cell death. In preclinical studies, HMA priming followed by 33A exposure upregulated CD33 expression, increased DNA incorporation of the PBD dimer, and enhanced cytotoxicity. In a phase 1 study, 33A plus HMA was generally well tolerated without a significant pattern of off-target toxicity. Activity of the combination was markedly improved compared to historical data of HMA monotherapy, with a high MRD-negative remission rate and activity maintained in the highest risk subgroups (Fathi et al, ASH 2016). Methods: This phase 3, randomized, double-blind, placebo-controlled global study was designed to compare overall survival between pts treated with 33A plus HMA vs. pts treated with placebo plus HMA (NCT02785900). Secondary endpoints include composite complete remission rate (CR/CRi), event-free survival, and safety. Approximately 500 pts will be randomized in a 1:1 manner to one of the study arms. Investigators may select either HMA (azacitidine or decitabine). Eligible pts are adults with newly diagnosed, previously untreated, de novo or secondary AML, and have intermediate or adverse cytogenetic risk. Pts must not have AML associated with favorable risk karyotype or be a candidate for allo-SCT. Combination treatment may be repeated every 4 weeks until disease progression, leukemic recurrence, or unacceptable toxicity. Study enrollment began in June 2016.
Proposing and empirically validating change impact analysis metrics (2018)

Dit PhD-project richt zich op het voorstellen van methoden en hulpmiddelen voor het beoordelen van veranderbaarheid en instabiliteit. Deze twee kwaliteitsattributen zijn van groot belang voor het uitvoeren van een efficiënte analyse van de veranderingseffecten, die van vitaal belang is tijdens de onderhoudsfase van de software. Wijzigingsimpactanalyse is belangrijk, zowel vóór als na de toepassing van de wijziging. Het project houdt rekening met bestaande literatuur, waarin we specifieke beperkingen hebben geïdentificeerd: (a) gebrek aan metrieken in de fasen van het architectonisch ontwerp en de vereisten, (b) gebrek aan nauwkeurigheid van de gegevens bij de implementatie en gedetailleerde ontwerpfasen, en (c) gebrek aan hulpmiddelen die het proces van de berekening ervan kunnen automatiseren. Rekening houdend met de bovengenoemde beperkingen, stelt het project vier nieuwe metrieken voor om de gevoeligheid en instabiliteit van veranderingen te kwantificeren op het niveau van eisen, architectuurontwerp en broncode. Alle statistieken zijn strikt gevalideerd met behulp van empirische methoden, zoals casestudy's over open source en industriële software, evenals wiskundige bewijzen. Empirische validatie is uitgevoerd op basis van de IEEE-standaard voor softwaremeting. De resultaten van alle onderzoeken suggereerden dat de voorgestelde meetwaarden de meest accurate voorspellers zijn van veranderlijkheid en instabiliteit. Op basis van de bevindingen zijn verschillende bruikbare resultaten voor zowel behandelaars als onderzoekers naar voren gekomen. Om de toepasbaarheid van de voorgestelde methoden in de praktijk te ondersteunen, worden alle statistieken vergezeld van een bijbehorende tool die hun berekening voor Java-projecten automatiseert.
Variability Management in IaaS (2016)

Flexible IT landscapes and efficient management of resources are key issues for enterprises. In cloud computing, varying requirements are discussed at application and platform level. In contrast, variability at cloud infrastructure level is seldom discussed. We have identified several variability requirements at infrastructure level from customer perspective. From service provider perspective, we also highlight which technical means needed to be employed to manage the variability. For elaboration, we provide examples for variability requirements and solutions. We also show with the help of a case study that how we can provide and manage variability using the software configuration tool Puppet. In the end, we summarize our paper and provide an outlook for future work.
A REAL-TIME TRACKING SYSTEM COMBINING TEMPLATE-BASED AND FEATURE-BASED APPROACHES (2007)

In this paper we propose a complete real-time model-based tracking system for piecewise-planar objects which combines template-based and feature-based approaches. Our contributions are an extension to the ESM algorithm (Benhimane and Malis, 2004) used for template-based tracking and the formulation of a feature-based tracking approach, which is specifically tailored for use in a real-time setting. In order to cope with highly dynamic scenarios, such as illumination changes, partial occlusions and fast object movement, the system adaptively switches between the template-based tracking, the feature-based tracking and a global initialization phase. Our tracking system achieves real-time performance by applying a coarse-to-fine optimization approach and includes means to detect a loss of track.
Mineralization of the dibenzothiophene biodegradation products 3-hydroxy-2-formyl benzothiophene and dibenzothiophene sulfone (1988)

Dibenzothiophene is degraded to 3-hydroxy-2-formyl benzothiophene by various bacteria, including a strain of Pseudomonas putida that also forms dibenzothiophene sulfone via an alternate pathway. By using these end products as substrates, mixed enrichment cultures that could degrade 3-hydroxy-2-formyl benzothiophene and dibenzothiophene sulfone with the formation of CO2 were established.
Anterior Cruciate Ligament Reconstruction with the Leeds-Keio Artificial Ligament (2000)

The Leeds-Keio (L-K) artificial ligament, developed for knee ligament reconstruction, is made of polyester with a maximum tensile strength of 2200 N. This implant works not only as a ligament but also as a scaffold onto which natural tissue grows from synovium. In an animal experiment, each strand of the L-K ligament was covered with new tissue by 2-3 weeks after anterior cruciate ligament reconstruction. Eight weeks postoperatively, abundant fibrous tissue with extensive vascularity covered the implant, which was still histologically immature. After 16 weeks, vascularization and tissue induction began to subside, and histologic analysis showed dense fibers running longitudinally and parallel. By 36 weeks, the new ligament looked like a natural anterior cruciate ligament, although histologically more cells could be seen than in the natural ligament. This maturation was observed only when the substitute was implanted under good tension. Clinically, the surgical procedure has been improved over the past 10 years, to the current practice in which the tape-in-tube double L-K ligament employs a small piece of autogenous tissue to promote early tissue induction and maturation. Using this practice (n = 135), more than 85% of the patients were satisfied subjectively, objectively, and arthroscopically at the 5-year postoperative FU period. Few patients had joint effusion postoperatively. Sacrifice of autogenous tissue is minimal. The patient can return to activities of daily living within 2 weeks, and more than 50% of them to sports within 10 weeks, and the new ligament is expected to keep its function for a long period as ingrowth completes the structure biologically.
STATISTICAL ISSUES IN THE CLUSTERING OF GENE EXPRESSION DATA (2001)

Abstract: This paper illustrates some of the problems which can occur in any data set when clustering samples of gene expression profiles. These include a possible high degree of dependence of results on choice of clustering algorithm, further dependence of results on the choices of genes and samples to be included in the clustering (for example, whether or not to include control samples), and difficulty in assessing the validity of the grouping. We also demonstrate the use of Cox regression as a tool to identify genes influencing survival.