gebhart/patrepeval huggingface dataset:
ChemInform Abstract: STUDIES IN POTENTIAL ANTIFERTILITY AGENTS PART 6, SYNTHESIS OF DIALKYLAMINOETHOXY DERIVATIVES OF 3,4-DIPHENYLCARBOSTYRIL, 3,4-DIPHENYLCINNOLINE, 2,3-DIPHENYL-4-QUINAZOLONE, AND 2,3-DIPHENYLQUINOXALINE (1973)

Durch Cyclisierung des Phenylacetamidobenzophenons (I) in Gegenwart von Na-äthoxid in siedendem Äthanol oder des Zimtsäureanilids (III) in Gegenwart von Polyphosphorsäure bei 150°C wird das Carbostyril (II) dargestellt.
Fully-integrated WCDMA SiGE BiCMOS transceiver (2005)

This paper describes a WCDMA transceiver integrated and in a SiGe-C 0.25um BiCMOS process featuring Ft=60GHz bipolar transistor. The receiver part includes integrated zero-IF RF-Front-End. The transmitter is based on Variable IF architecture and includes a 64 dB gain control. All required PLL's and associated VCO's are also integrated. The receiver power consumption is 37mA (PLL included) and the transmitter consumes 60mA both under 2.7V power supply generated by an internal low drop regulator (LDO) directly connected to the battery voltage. Within the receive band, the receiver measurements shown 64dB of overall gain with a 5 dB NF DSB. The transmitter maximum output power is -3 dBm.
Nominaciones brasileñas a los Juegos Olímpicos: reflexiones sobre el mito de la separación entre la política y el movimiento olímpico (2010)

Ao longo do seculo XX os Jogos Olimpicos se transformaram em um dos principais eventos culturais do planeta e sua organizacao demanda envolvimento direto do poder publico e da iniciativa privada. No principio do seculo passado o poder publico era inteiramente responsavel pela candidatura e realizacao do evento. No presente, desde o momento em que a cidade se candidata e apresenta seu projeto ela necessita criar uma infra-estrutura para viabilizar, no principio, sua postulacao, afirmar sua especificidade e, por fim, viabilizar sua capacidade para realizar o evento. Embora os eventos sejam iniciativas privadas o que se observa e o intenso envolvimento do poder publico com um nivel de transparencia que varia conforme o momento historico e o governo no poder. O objetivo deste trabalho e discutir as postulacoes brasileiras aos Jogos Olimpicos e sua relacao com as instituicoes publicas que lhe deram suporte.
Real-Time Tracking Filter Evaluation and Selection for Tactical Applications (1971)

Five important tracking filters that are often candidates for implementation in systems that must track maneuvering vehicles are compared in terms of tracking accuracy and computer requirements for tactical applications. A rationale for selecting among these filters, which include a Kalman filter, a simplified Kalman filter, an α-ß filter, a Wiener filter, and a two-point extrapolator, is illustrated by two examples taken from the authors' recent experience.
Resuscitative hypothermia (1996)

Resuscitative (postinsult) hypothermia is less well studied than protective-preservative (pre- and intra-arrest) hypothermia. The latter is in wide clinical use, particularly for protecting the brain during cardiac surgery. Resuscitative hypothermia was explored in the 1950s and then lay dormant until the 1980s when it was revived. This change occurred through the discoveries of brain damage mitigating effects after cardiac arrest in dogs, and after forebrain ischemia in rats, of mild (34 degrees C) hypothermia (which is safe), and of benefits derived from moderate hypothermia (30 degrees C) after traumatic brain injury or focal brain ischemia in various species. The idea that protection-preservation or resuscitation by hypothermia is mainly explained by its ability to reduce cerebral oxygen demand has been replaced by an increasingly documented synergism of many beneficial mechanisms. Deleterious chemical cascades during and after these insults are suppressed even by mild hypothermia. Prolonged moderate hypothermia carries some risks, e.g., arrhythmias, infection and coagulopathies. These side effects need further study. In global brain ischemia, protective-preservative mild hypothermia provides lasting mitigation of brain damage. Resuscitative mild hypothermia, however, may be beneficial in terms of long-term outcome or may merely delay the inevitable loss of selectively vulnerable neurons. Even if the latter is true, mild hypothermia may extend the therapeutic window for other interventions. This extension of the therapeutic window requires further documentation. After normothermic cardiac arrest of 11 mins in dogs, mild resuscitative hypothermia from 15 mins to 12 hrs after reperfusion plus cerebral blood flow promotion normalized functional recovery with the least histologic damage seen thus far. Optimal duration of, and rewarming methods from, resuscitative hypothermia need clarification. The earliest possible induction of mild hypothermia after cardiac arrest seems desirable. Head-neck surface cooling alone is too slow. Among many clinically feasible rapid cooling methods, carotid cold flush and peritoneal cooling look promising. After traumatic brain injury or focal brain ischemia, which seem to still benefit from even later cooling, surface cooling methods may be adequate. Resuscitative hypothermia after cardiac arrest, traumatic brain injury, or focal brain ischemia should be considered for clinical trials. (Crit Care Med 1996; 24(Suppl):S81-S89)
A new non-steroidal anti-inflammatory analgesic: gamma-oxo (1,1'-biphenyl)-4-butanoic acid (fenbufen). Chemistry and activity of analogs. (1980)

100 analogs of gamma-oxo(1,1'-biphenyl)-4-butanoic acid (fenbufen) were prepared and tested using the carrageenin, polyarthritis, and UV erythema anti-inflammatory tests and the 2-phenyl-1,4-benzoquinone writhing and inflamed paw pressure analgesic tests. Only three retained the same full spectrum of activity as fenbufen: dl-4-(4-biphenyly)-4-hydroxybutyric acid, dl-4-(4-biphenylyl)-1,4-butanediol, and 4-biphenylacetic acid. Fenbufen had the same spectrum of activity as acetylsalicylic acid (ASA), phenylbutazone, and indometacin in the five tests. In addition, dose-response derived potencies show fenbufen more potent than ASA and at least as potent as phenylbutazone in all five tests.
From Loci to Networks and Back Again (2008)

Recent developments in functional imaging as well as the emergence of new anatomical imaging techniques suited for the study of white matter have shifted investigational paradigms from a localized to a more holistic network approach. Aside from detecting local activity, functional MRI can be applied to the study of connectivity. However, the concept of "functional connectivity" remains broad, and specific designs and analyses may affect the results. In addition, connectivity cannot be viewed in isolation. Rather, from a developmental perspective, connectivity and local cortical architecture are intimately related. Therefore, combined approaches examining local organization and connectivity are the most promising avenues for elucidating disturbances of neurofunctional organization in developmental disorders. Here this approach is illustrated via data obtained from autism research that suggest impaired local cortical architecture and reduced long-range connectivity between cerebral regions.
Histone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited success (2016)

Histone deacetylase inhibitors (HDACi) are in clinical trials against a variety of cancers. Despite early successes, results against the more common solid tumors have been mixed. How is it that so many cancers, and most normal cells, tolerate the disruption caused by HDACi-induced protein hyperacetylation? And why are a few cancers so sensitive? Here we discuss recent results showing that human cells mount a coordinated transcriptional response to HDACi that mitigates their toxic effects. We present a hypothetical signaling system that could trigger and mediate this response. To account for the existence of such a response, we note that HDACi of various chemical types are made by a variety of organisms to kill or suppress competitors. We suggest that the resistance response in human cells is a necessary evolutionary consequence of exposure to environmental HDACi. We speculate that cancers sensitive to HDACi are those in which the resistance response has been compromised by mutation. Identifying such mutations will allow targeting of HDACi therapy to potentially susceptible cancers. Also see the video abstract here.
A phase-coherent numerically controlled oscillator based on pipeline architecture (2002)

A design of a pipeline architecture for a phase coherent numerically controlled oscillator (NCO) is presented. The NCO synchronously generates sampled sinusoidal waveforms A cos(2/spl pi/ft+/spl phi/) and A sin(2/spl pi/ft+/spl phi/), as 16-bit signed integer values. The pipeline architecture includes multipliers, adders, and a 64K/spl times/16 embedded ROM. The proposed NCO provides waveform phase coherency relative to the time reference over varying frequencies, which is essential for coherent radar seekers using stepped frequency in Doppler synthesis.
Case History of the 31S Peripheral Waterflood Project, Stevens Zone, Elk Hills Field, California (1996)

Abstract This paper summarizes and contrasts the peripheral waterflood performance of two reservoirs that constitute the 31S project in the Elk Hills Field, Kern County, California. The combination of light oil (36 API), favorable mobility ratio (0.4) and an anticlinal structure makes these sandstones good candidates for peripheral flooding. From 1978 until December 1995 cumulative water injection in the 31S project was 371 million barrels and cumulative recovery was 155 million barrels of oil. Early initiation of a pressure maintenance project including 117 BCF crestal gas injection has improved oil recovery. The Main Body 'B' reservoir is exhibiting a distinctly layered response with high recovery from its more permeable layers and lower recovery from tighter layers. This flood has the potential for bypassed reserves. The Western 31S reservoir has moderate to high dips and is exhibiting a less layered flood response and very efficient displacement. The gravity drainage component from the secondary gas cap is playing a significant role in the process. Aside from high recovery, the project is remarkable in demonstrating successful resaturation of a secondary gas cap. Future work will include refinement of original-oil-in-place (OOIP) estimates with a new petrophysical model and improving tight layer management by pattern waterflooding and increasing productivity and injectivity with stimulation treatments. Introduction In the literature there are a few papers describing peripheral waterfloods. The 31S project in the Elk Hills Field, California provides an opportunity to study a large, mature peripheral waterflood and to see the effects of a long term injection into two very different reservoirs. The Elk Hills Field is located about 20 miles WSW of Bakersfield, California (Fig. 1). It is one of the 10 most productive oil fields in the United States with a cumulative recovery of over one billion barrels to date. The Main Body 'B' (MBB) and Western 31S (W31S) sands occur at an average depth of 6,500 ft. The zone was discovered in 1941. The field was held in reserve and only periodically produced until 1976 when it was opened up to production at capacity. The current production from the MBB and W31S reservoirs is about 11,300 BOPD and 3,500 BOPD respectively. The mechanism for primary production from for the MBB and W31S reservoirs was a combination of solution gas, partial water drive, and some contribution from gravity drainage. The primary recovery factor was estimated to be in the range of 12% of the OOIP. Since the onset of the exploitation, secondary recovery was considered essential for the MBB and W31S reservoirs. P. 227
Wave-measurement capabilities of the surface contour radar and the airborne oceanographic lidar (1987)

The 36-gigahertz surface contour radar and the airborne oceanographic lidar were used in the SIR-B underflight mission off the coast of Chile in October 1984. The two systems and some of their wave-measurement capabilities are described. The surface contour radar can determine the directional wave spectrum and eliminate the 180-degree ambiguity in wave propagation direction that is inherent in some other techniques such as stereophotography and the radar ocean wave spectrometer. The Airborne Oceanographic Lidar can acquire profile data on the waves and produce a spectrum that is close to the nondirectional ocean-wave spectrum for ground tracks parallel to the wave propagation direction.
A Regularized Method for Peptide Quantification (2010)

Peptide abundance estimation is generally the first step in protein quantification. In peptide abundance estimation, peptide overlapping and peak intensity variation are two challenges. The main objective of this paper is to estimate peptide abundance by taking advantage of peptide isotopic distribution and smoothness of peptide elution profile. Our method proposes to solve the peptide overlapping problem and provides a way to control the variance of estimation. We compare our method with a commonly used method on simulated data sets and two real data sets of standard protein mixtures. The results show that our method achieves more accurate estimation of peptide abundance on different samples. In our method, there is a variance-related parameter. Considering the well-known trade-off between the variance and the bias of estimation, we should not only focus on reducing the variance in real applications. A suggestion about parameter selection is given based on the discussion of variance and bias. Matlab source codes and detailed experimental results are available at http://bioinformatics.ust.hk/PeptideQuant/peptidequant.htm.
Conceptual design of a lunar colony (1972)

A systems engineering study is presented for a proposed lunar colony. The lunar colony was to grow from an existent, 12-man, earth-dependent lunar surface base and was to utilize lunar resources, becoming as earth-independent as possible. An in-depth treatment of some of the aspects of the lunar colony was given. We have found that the use of lunar resources is feasible for oxygen production (both for breathing and for space tug fuel), food production, and building materials. A program is outlined for recycling waste materials developed at the colony as well as a full program for growth and research activity of the colony to a level of 180 colonists. Recommendations for the lunar colony are given.
Circular test structure for the determination of piezoelectric constants of Sc x Al 1−x N thin films applying Laser Doppler Vibrometry and FEM simulations (2014)

Piezoelectric scandium aluminium nitride (Sc <sub><i>x</i></sub> Al<sub>1-<i>x</i></sub> N) thin films offer a large potential for the application in micro electromechanical systems, as advantageous properties of pure AlN thin films are maintained, but combined with an increased piezoelectric actuation and sensing potential. Sc <sub><i>x</i></sub> Al<sub>1-<i>x</i></sub> N thin films with <i>x</i> = 27% have been prepared by DC reactive magnetron sputtering to find optimized deposition parameters to maximize the piezoelectric constants <i>d</i><sub>33</sub> and <i>d</i><sub>31</sub>. For the accurate and simultaneous measurement of these constants Laser Doppler Vibrometry has been applied and compared to finite element (FEM) simulations. The electrode design has been optimized to rotational symmetric structures enabling a 180° phase shifted excitation, so that a straight-forward comparison of experimental displacement curves with those obtained from FEM is feasible.
Diffusion-Tensor MRI at 3 T: Differentiation of Central Gland Prostate Cancer From Benign Prostatic Hyperplasia (2014)

DTI at 3 T is useful for distinguishing central gland cancers from BPH foci, with significantly different ADC and FA values. Furthermore, ADC showed greater diagnostic accuracy than FA in differentiating central gland cancers from stromal and glandular hyperplasia foci.
Effects of Flow Settling Means on the Performance of Fan Tester (2005)

In this study, the effect of flow settling means on the performance of fan tester were numerically investigated by using a computational fluid dynamics(CFD). The airflow rate was calculated from the pressure differential across a flow nozzle in the measuring plane and the flow settling means were generally installed in the chamber of the fan tester to provide proper airflow patterns ahead of the measuring plane. The predicted nozzle differential pressures with uniform inlet velocities were compared with the values of the ANSI/AMCA 210-99 to verify the performance of the commercial CFD code CFX 5.6. The influence of flow settling means on the measurement of airflow rate in a fan tester were discussed with various porosities and inlet jet velocities. The results obtained show that the proper band of porosities exist to meet the AMCA standard in a specified inlet jet velocity.
Pepsin digestibility of proteins in sorghum and other major cereals (1984)

We have shown previously that sorghum is highly digestible in the rat. However, other workers have shown that sorghum is much less digestible than wheat, maize, and rice in young children. Because the rat does not show these digestibility differences, we developed an empirical pepsin digestion method, first reported in 1981, which simulates the digestion values found in children. In this report the method has been improved and used to analyze wheat, maize, rice, millet, and sorghum and certain processed samples of millet and sorghum. The pepsin digestion values parallel those found in children for wheat, maize, rice, and sorghum. In addition, a processed sorghum product that gave a high digestion value in children also gave a high value with the in vitro pepsin method.
Preclinical characterization of a new pasteurized monoclonal antibody purified factor VIIIC. (1990)

The treatment of hemophilia A patients has progressed in the last 30 years. The development of more pure factor VIII concentrates has been encouraged by the appearance of the human immunodeficiency virus in blood supply. Monoclate was the first essentially pure form of factor VIII available for hemophilia therapy. The liquid pasteurized form of Monoclate represents a new standard for therapy that attempts to eliminate a broad spectrum of viral content in factor VIII preparations.
Physical properties of RT-LPCVD and LPCVD polysilicon thin films: application to emitter solar cell (2002)

This investigation was implemented in the framework of a novel all-low thermal budget polysilicon emitter solar cells fabrication technology. A comparative study of structural and electrical properties of thin silicon layers deposited by silane pyrolysis in a classical hot-wall furnace (LPCVD) and a cold-wall RTP reactor (RT-LPCVD) has been made. Deposition conditions and rapid thermal anneals were varied in order to improve the physical properties of RT-LPCVD polysilicon films. The structural properties have been characterized by means of grazing X-ray diffraction and cross-sectional TEM analysis. Sheet resistivity measurements performed on POCl/sub 3/-doped and subsequently rapid thermal annealed films showed the feasibility of low resistivity films particularly when the polysilicon layers are initially deposited in the amorphous state. Finally, RTCVD polysilicon emitter solar cells with various thicknesses were tested by spectral photo-response analysis.
A burst-error-correcting algorithm for Reed-Solomon codes (1992)

It is known that for a burst-error environment, the error-correcting capability of Reed-Solomon codes can be extended beyond the Singleton bound with a high degree of confidence. This is significant in that an (n, k) code with an arbitrarily small probability of a miscorrection can correct more than (n-k)/2 errors. A decoding algorithm for correcting a burst of length greater than (n-k)/2 is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
PET Image Reconstruction Using Anatomical Information Through Mutual Information Based Priors (2006)

We propose a non-parametric method for incorporating information from co-registered anatomical images into PET image reconstruction through priors based on mutual information. Mutual information between feature vectors extracted from the anatomical and functional images is used as a priori information in a Bayesian framework for the reconstruction of the PET image. The computation of mutual information requires an estimate of the joint density of the two images, which is obtained by using the Parzen window method. Preconditioned conjugate gradient with a bent Armijo line-search is used to maximize the resulting posterior density. The performance of this method is compared with that using a Gaussian quadratic penalty, which does not use anatomical information. Simulation results are presented for PET and MR images generated from a slice of the Hoffman brain phantom. These indicate that mutual information based penalties can potentially provide superior quantitation compared to Gaussian quadratic penalties
Synovial membrane expression of matrix metalloproteinases and tissue inhibitor 1 in juvenile idiopathic arthritides. (2002)

The expression of MMP-1 and MMP-3 in the synovium of patients with IA was clearly correlated with the degree of inflammation. This indicates the possible role of MMP in the pathogenesis of synovitis in this group of pediatric idiopathic arthritides. Inadequate expression of tissue inhibitors may represent a crucial event for the development and perpetuation of tissue damage.
A framework for integrating design automation with computer aided parametric estimating (CAPE) (2002)

This paper will identify a shortcoming in the Design-To-Cost (DTC) capability of the military/aerospace industry and propose an integrated product development environment (IPDE) solution based upon: the electronic integration of computer aided parametric estimating (CAPE) tools with computer aided engineering (CAE) tools the organizational integration of cost analysts and engineers via integrated product development teams (IPDT's). This solution is referred to as integrated Design-To-Cost (IDTC). An IDTC toolset consisting of two mature, commercially available products (PRICE systems PRICE enterprise CAPE tool and ascent logic's RDD-100 systems engineering tool) will be used as an example of IDTC. DARPA's rapid prototyping of application specific signal processors (RASSP) program provided the seed funding, enabling the creation of IDTC under the guidance of Lockheed Martin's Advanced Technology Laboratories (Camden, NJ).