gebhart/patrepeval huggingface dataset:
Resonance energy transfer from a dye molecule to graphene (2008)

We study the distance dependence of the rate of resonance energy transfer from the excited state of a dye to the pi system of graphene. Using the tight-binding model for the pi system and the Dirac cone approximation, we obtain the analytic expression for the rate of energy transfer from an electronically excited dye to graphene. While in traditional fluorescence resonance energy transfer, the rate has a (distance)(-6) dependence, we find that the distance dependence in this case is quite different. Our calculation of rate in the case of the two dyes, pyrene and nile blue, shows that the distance dependence is Yukawa type. We have also studied the effect of doping on energy transfer to graphene. Doping does not modify the rate for electronic excitation energy transfer significantly. However, in the case of vibrational transfer, the rate is found to be increased by an order of magnitude due to doping. This can be attributed to the nonzero density of states at the Fermi level that results from doping.
Predicting the progression of ophthalmic disease based on slit-lamp images using a deep temporal sequence network (2018)

Ocular images play an essential role in ophthalmology. Current research mainly focuses on computer-aided diagnosis using slit-lamp images, however few studies have been done to predict the progression of ophthalmic disease. Therefore exploring an effective approach of prediction can help to plan treatment strategies and to provide early warning for the patients. In this study, we present an end-to-end temporal sequence network (TempSeq-Net) to automatically predict the progression of ophthalmic disease, which includes employing convolutional neural network (CNN) to extract high-level features from consecutive slit-lamp images and applying long short term memory (LSTM) method to mine the temporal relationship of features. First, we comprehensively compare six potential combinations of CNNs and LSTM (or recurrent neural network) in terms of effectiveness and efficiency, to obtain the optimal TempSeq-Net model. Second, we analyze the impacts of sequence lengths on model's performance which help to evaluate their stability and validity and to determine the appropriate range of sequence lengths. The quantitative results demonstrated that our proposed model offers exceptional performance with mean accuracy (92.22), sensitivity (88.55), specificity (94.31) and AUC (97.18). Moreover, the model achieves real-time prediction with only 27.6ms for single sequence, and simultaneously predicts sequence data with lengths of 3-5. Our study provides a promising strategy for the progression of ophthalmic disease, and has the potential to be applied in other medical fields.
Simultaneous cancellation of cross interference and ISI in CDMA mobile radio communications (2003)

In this paper, data estimation in the uplink of a synchronous mobile radio system applying CDMA is considered. In mobile radio systems applying CDMA, multipath propagation leads on the one hand to ISI and on the other hand, together with time-variance, to cross interference between the signals of different users, regardless whether the user codes are chosen orthogonal or not. A linear unbiased data estimation algorithm is presented which cancels both ISI and cross interference perfectly by jointly detecting the different user signals, thus leading to unbiased estimates of the transmitted data symbols. This algorithm is less complex than MLSE performed e.g. by the Viterbi algorithm and furthermore, the complexity does not depend on the kind of the applied linear modulation scheme, which opens a simple way to offer services with different data rates in one system. By theoretical analysis and simulation, the performance of the unbiased data estimation algorithm is examined under the assumption that the radio channel impulse responses are known at the receiver. The price to be paid for the interference cancellation is SNR-degradations, which are calculated for typical mobile radio situations in urban areas. The resulting average uncoded bit error probabilities lead to the conclusion that systems applying the unbiased data estimation algorithm are well-suited for mobile radio applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Electrochemical, Magnetic, and Structural Investigation of the Li<i><sub>x</sub></i>(Mn<i><sub>y</sub></i>Fe<sub>1</sub><sub>-</sub><i><sub>y</sub></i>)PO<sub>4</sub> Olivine Phases (2006)

A series of synthetic heterosite−purpurite, (MnyFe1-y)PO4 (y < 0.8), with negligible disorder and impurities, was obtained by chemical oxidation of the well-crystallized isotypic tryphillite−lithiophilite series, Li(MnyFe1-y)PO4 (ordered olivine structure, space group Pnma). Comparative magnetic and X-ray/neutron powder diffraction investigations of the two solid−solution lines were performed as a function of Mn content to increase understanding of the electrochemical activity loss of Mn3+/Mn2+ in the Lix(MnyFe1-y)PO4 electrode system. Introducing Mn ions into the 4c site did not cause significant change in the local geometry of M2+O6 and PO4 polyhedra, while the M3+O6 octahedra became severely distorted with an increase in the number of Jahn−Teller active Mn3+ ions. The edge-sharing geometry of M3+O6 and PO4 polyhedra fixed the shared O3‘−O3‘ interatomic distance, causing selective strong elongation of the M3+−O3‘ distance with small shrinkage of other M3+−O1, M3+−O2, and M3+−O3 bond lengths. The overall distortion of the MO6 octahedra with M = Mn3+ was much larger than the corresponding change in the unit-cell orthorombicity and significantly increased asymmetry in the M−O−M superexchange interaction. All samples exhibited antiferromagnetism; however, the trivalent series had more than a sevenfold larger decrease in Neel temperature TN (from ca. 130 K at y = 0 to ca. 50 K at y = 0.8) compared to the divalent series (from ca. 52 K at y = 0 to ca. 35 K at y =1) as a function of the Mn content y.
Mobile Supercomputers for the Next-Generation Cell Phone (2010)

AnySP demonstrates that power efficiency can be achieved on a fully programmable processor in the context of a future mobile terminal supporting 4G wireless and high-definition video coding.
Fluorescence quenching in model membranes. 1. Characterization of quenching caused by a spin-labeled phospholipid (1981)

A new method is described to evaluate contact between fluorophors and lipids in model membranes. This method utilizes a nitroxide spin-labeled phosphatidylcholine to quench th fluorescence from a variety of membrane-bound molecules by a static process. The distance dependence of the fluorescence quenching is analyzed in terms of simple models. The analysis shows that quenching of diphenylhexatriene, p-terphenyl, and molecules containing tryptophan arises only from spin-labeled phospholipid that is in contact with the fluorophor.
Bacterial bile salt hydrolase in host metabolism: Potential for influencing gastrointestinal microbe-host crosstalk (2014)

Controlled, reductionist approaches are required in order to obtain a more complete understanding of the functional capabilities of the gut microbiota. We recently identified microbial bile salt hydrolase (BSH) activity as a gut microbial activity that has the capacity to profoundly alter both local (gastrointestinal) and systemic (hepatic) host functions. Using both germ free and conventionally-raised mouse models we demonstrated that gastrointestinal expression of BSH results in local bile acid deconjugation with concomitant alterations in lipid and cholesterol metabolism, signaling functions and weight gain. Key mediators of cholesterol homeostasis (Abcg5/8), gut homeostasis (RegIIIγ) and circadian rhythm (Dbp) were influenced by elevated BSH in our study. In this addendum we discuss the implications of this work for the rational development of probiotics with the potential to modulate host weight gain.
A soft-error-immune 0.9-ns 1.15-Mb ECL-CMOS SRAM with 30-ps 120 k logic gates and on-chip test circuitry (2002)

A soft-error-immune 0.9-ns 1.15-Mb ECL-CMOS SRAM with 30-ps 120 k logic gates has been developed. To provide good testability, reliability, and stability, on-chip test circuitry, a memory-cell test technique, a highly stable current source, and a soft-error-immune memory cell are proposed.
<p>Immunotherapeutic Targets and Therapy for Renal Cell Carcinoma</p> (2020)

Over the last 20 years, different therapies have been considered as the mainstay for the treatment of patients with metastatic renal cell carcinoma (mRCC). Since angiogenesis is a key mechanism in the pathogenesis of renal carcinoma, research is still focusing on the inhibition of new vessel growth through the development of novel and potent tyrosine kinase inhibitors (TKIs), such as cabozantinib. On the other hand, a new therapeutic scenario has opened up in the forefront with immunotherapy. Immune checkpoint inhibitors (ICIs), which already represent a standard treatment option in pretreated mRCC patients, are revolutionizing the frontline therapeutic armamentarium of mRCC. Upfront combination immunotherapy as well as combinations of immunotherapy with targeted agents showed to significantly improved outcomes of mRCC patients compared to single-agent TKIs. ICIs are associated with long-lasting responses. Nonetheless, several unmet needs remain, as a small proportion of patients shows primary refractoriness to immunotherapy. Multiple treatment strategies combining different mechanisms of action or targeting immune escape pathways are emerging with the aim to improve response rates and survival outcomes. This review summarizes current immunotherapeutic targets and therapies approved for mRCC, while examining mechanisms of resistance and future directions, with the aim to address novel treatment strategies and help in improving the management of this tumor.
Visualizing the behavior of object-oriented systems (1993)

article Visualizing the behavior of object-oriented systems Share on Authors: Wim De Pauw View Profile , Richard Helm View Profile , Doug Kimelman View Profile , John Vlissides View Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 28Issue 10Oct. 1, 1993 pp 326–337https://doi.org/10.1145/167962.165919Online:01 October 1993Publication History 88citation896DownloadsMetricsTotal Citations88Total Downloads896Last 12 Months52Last 6 weeks8 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Superconducting analogue electronics for research and industry (2003)

This paper gives a brief review of superconducting electronics in research and industry. Examples will show how science benefits from the development and how superconducting devices have found their way into industry and to some commercial products. Impact in terms of enabling new research in other fields (e.g. radio astronomy, medicine), in industry (certification, safety, metrology, etc) and in terms of market will be addressed. From the examples, two fields will be emphasized: superconducting detectors for astronomy and the superconducting quantum interference devices (SQUIDs) employed for different applications.
Interleukin 6 Facilitates Corneal Epithelial Wound Closure In Vivo (1992)

Rapid corneal epithelial wound healing is essential to the maintenance of clear visual acuity. The cytokine interleukin 6 is thought to participate in the wound-healing process. We investigated the effect of interleukin 6 eye drops on the rate of corneal epithelial wound closure in rabbits in vivo. Recombinant human interleukin 6 in phosphate-buffered saline at concentrations of 0.1, 0.3, or 1 mg/L was administered immediately after the epithelium was débrided with the n-heptyl alcohol treatment and 2, 4, 6, 8, 10, 18, 20, 22, 24, 26, and 28 hours after débridement. The eyes were stained with fluorescein and photographed at baseline and at 7, 10, 18, 21, 24, 27, 30, and 43 hours after débridement. The rate of wound healing was calculated with a linear regression analysis based on the areas of the epithelial defects, which were recorded from hour 10 to hour 30. The mean (+/- SD) healing rate in the control group, which received phosphate-buffered saline alone, was 1.03 +/- 0.15 mm2/h. The administration of interleukin 6 at concentrations of 0.1, 0.3, or 1.0 mg/L increased the healing rate significantly (P less than .001) to 1.27, 1.39, or 1.44 mm2/h, respectively. Our results indicate that the administration of interleukin 6 might have clinical applications in the treatment of persistent corneal epithelial defects.
The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast transplantation and gene therapy (2002)

HLA-G is a non-classical MHC class I molecule with highly limited tissue distribution which has been attributed chiefly immune-regulatory functions. We previously have reported that HLA-G is expressed in inflamed muscle in vivo and by cultured myoblasts in vitro. Here, we used the in vitro models of human myoblasts or TE671 muscle rhabdomyosarcoma cells to characterize the functional role of HLA-G for muscle immune cell interactions. Gene transfer of the two major isoforms of HLA-G (transmembranous HLA-G1 and soluble HLA-G5) into TE671 rendered these cells resistant to alloreactive lysis by direct inhibition of natural killer (NK) cells, and CD4 and CD8 T cells. Further, HLA-G reduced alloproliferation, interfered with effective priming of antigen-specific cytotoxic T cells and reduced antigen-specific alloreactive lysis. HLA-G pre-induced on cultured myoblasts inhibited lysis by alloreactive peripheral blood mononuclear cells. This protection was reversed by a neutralizing HLA-G antibody. Interestingly, a few HLA-G-positive cells within a population of HLA-G-negative muscle target cells conveyed significant inhibitory effects on alloreactive lysis. Our results reveal further insights into the immunobiology of muscle and suggest that ectopic expression of HLA-G may promote the survival of transplanted myoblasts in the future treatment of hereditary muscle diseases. Further, HLA-G could represent a novel self-derived anti-inflammatory principle applicable in strategies against inflammatory aggression.
Synthesen mit Dicarbonsäuren, XIX. Mitteil.: Darstellung von ω‐Aminocarbonsäuren durch halbseitigen Hofmann schen Abbau von Dicarbonsäuren (1956)

Abstract ω‐Aminocarbonsäuren wurden in guter Ausbeute aus den Monoamiden aliphatischer Dicarbonsäuren durch Hofmannschen Abbau erhalten. Der Abbau von Bernstein‐ und Glutarsäure wurde in wäßriger, der von Pimelin‐, Kork‐, Azelain‐, Sebacin‐ und Tetradecandisäure in absolut methanolischer Lösung über die Urethane nach E. Jeffreys vorgenommen.
Applying collaborative filtering techniques to movie search for better ranking and browsing (2007)

We propose a new ranking method, which combines recommender systems with information search tools for better search and browsing. Our method uses a collaborative filtering algorithm to generate personal item authorities for each user and combines them with item proximities for better ranking. To demonstrate our approach, we build a prototype movie search and browsing engine called MAD6 (Movies, Actors and Directors; 6 degrees of separation). We conduct offline and online tests of our ranking algorithm. For offline testing, we use Yahoo! Search queries that resulted in a click on a Yahoo! Movies or Internet Movie Database (IMDB) movie URL. Our online test involved 44 Yahoo! employees providing subjective assessments of results quality. In both tests, our ranking methods show significantly better recall and quality than IMDB search and Yahoo! Movies current search.
Enhancing workflows by web technology (1997)

This paper presents a hybrid approach for the support of workflows in a ministerial environment that integrates a Web-based interface into a groupware platform. A scenario of the application area is examined to identify the basic requirements for an adequate user support. The basic PoLffeam approach for the support of workflows by electronic circulation folders is introduced. Focal point of the paper is the design of the Web-based interface for the interaction with electronic circulation folders and its seamless integration into the groupware platform.
The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation (2006)

Virulence of Mycobacterium tuberculosis and related pathogenic mycobacteria requires the secretion of early secretory antigenic 6 kDa (ESAT-6) and culture filtrate protein 10 (CFP-10), two small proteins that lack traditional signal sequences and are exported through an alternative secretion pathway encoded primarily by the RD1 genetic locus. Mutations affecting the synthesis or secretion of ESAT-6 or CFP-10 attenuate the virulence of M. tuberculosis in murine models of infection. However, the specific functions of these proteins and of their secretion system are currently unclear. In this study, we isolated a mutant of Mycobacterium marinum defective in the secretion of ESAT-6 and CFP-10. The mutation was localized within MM5446, which is orthologous to Rv3871 of M. tuberculosis H37Rv and encodes an ATPase that is a component of the ESAT-6/CFP-10 secretion system. The mutant bacteria were unable to replicate within J774 macrophages although their growth in 7H9 medium was equivalent to the parental strain. Phagosome maturation and acidification were analysed in infected macrophages by confocal and electron microscopy using the late endosome/lysosome marker LAMP-1, along with various fluid-phase markers such as rhodamine-dextran and ferritin and the acidotropic dye LysoTracker Red. These studies demonstrated that while the wild-type parental strain of M. marinum primarily resides in a poorly acidified, non-lysosomal compartment, a significantly higher percentage of the MM5446 mutant organisms are in acidified compartments. These results suggest that the ESAT-6/CFP-10 secretion system plays a role in preventing phagolysosomal fusion, a novel function that accounts for the ability of bacteria to survive inside host cells. This finding provides a mechanism by which the ESAT-6/CFP-10 secretion system potentiates the virulence of pathogenic mycobacteria.
SUPERSEDED - CSTR VCTK Corpus: English Multi-speaker Corpus for CSTR Voice Cloning Toolkit (2016)

# SUPERSEDED - This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/1994 . # This CSTR VCTK Corpus (Centre for Speech Technology Voice Cloning Toolkit) includes speech data uttered by 109 native speakers of English with various accents. Each speaker reads out about 400 sentences, most of which were selected from a newspaper plus the Rainbow Passage and an elicitation paragraph intended to identify the speaker's accent. The newspaper texts were taken from The Herald (Glasgow), with permission from Herald & Times Group. Each speaker reads a different set of the newspaper sentences, where each set was selected using a greedy algorithm designed to maximise the contextual and phonetic coverage. The Rainbow Passage and elicitation paragraph are the same for all speakers. The Rainbow Passage can be found in the International Dialects of English Archive: (http://web.ku.edu/~idea/readings/rainbow.htm). The elicitation paragraph is identical to the one used for the speech accent archive (http://accent.gmu.edu). The details of the speech accent archive can be found at http://www.ualberta.ca/~aacl2009/PDFs/WeinbergerKunath2009AACL.pdf . All speech data were recorded using an identical recording setup: an omni-directional head-mounted microphone (DPA 4035), 96kHz sampling frequency at 24 bits and in a hemi-anechoic chamber of the University of Edinburgh. All recordings were converted into 16 bits, downsampled to 48 kHz based on STPK, and manually end-pointed. This corpus was recorded for the purpose of building HMM-based text-to-speech synthesis systems, especially for speaker-adaptive HMM-based speech synthesis using average voice models trained on multiple speakers and speaker adaptation technologies. The file was previously available on the CSTR website, and was referenced in the Google DeepMind work on WaveNet: https://arxiv.org/pdf/1609.03499.pdf .
An introduction to electronic theories of organic chemistry (1958)

An introduction to electronic theories of organic chemistry , An introduction to electronic theories of organic chemistry , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Monolithically Integrated Inertial Sensors (2005)

This chapter contains sections titled: Introduction Integrated Polysilicon Inertial Sensors Thin-film Inertial Sensors within Foundry CMOS Metal Inertial Sensors Bulk Silicon Integrated MEMS Inertial Sensors Future Prospects References
Inhibition of factor XIIIa-mediated incorporation of fibronectin into fibrin by pulmonary surfactant (1999)

Intra-alveolar deposition of exudated plasma proteins is a hallmark of acute and chronic inflammatory lung diseases. In particular, fibrin and fibronectin may provide a primary matrix for fibrotic lung remodeling in the alveolar compartment. The present study was undertaken to explore the effect of two surfactant preparations on the incorporation of fibronectin into fibrin. We observed that surfactant phospholipids are associated with insoluble fibrin, factor XIIIa-cross-linked fibrin, and cross-linked fibrin with incorporated fibronectin. Factor XIIIa-mediated binding of fibronectin to fibrin was noticeably altered in the presence of surfactant. Coincubation with two different commercially available surfactants but not with dipalmitoylphosphatidylcholine alone resulted in a reduction of fibronectin incorporation into fibrin clots by approximately one-third. This effect was not dependent on the calcium concentration. We conclude that 1) factor XIIIa-cross-linked fibrin-fibronectin is able to incorporate surfactant phospholipids in amounts comparable to fibrin clots without fibronectin and 2) the binding of fibronectin to fibrin is partially inhibited in the presence of pulmonary surfactant.