gebhart/patrepeval huggingface dataset:
[Regulation of matrix-degrading enzymes in gynecologic cancer tissues and cells]. (1996)

We have examined the gelatinolytic activity in gynecologic normal and cancer tissues by zymography and reverse zymography. Ovarian, cervical, and endometrial cancer tissues demonstrated higher gelatinolytic activity than normal tissues. The major gelatinases were those with molecular weight of 92 and 72kD, which corresponded to MMP-9 and MMP-2, respectively. The ratio of MMP 9 to MMP-2 was significantly higher in 3 types of cancer tissues than in normal tissues. Reverse zymography demonstrated that TIMP-1 and TIMP-2 were present in all tissues, and the ratio of TIMP-1 to TIMP-2 was significantly higher in 3 types of cancer tissues than in normal tissues. These findings suggested that MMP-9 and TIMP-1 were more associated with cancer phenotype than other types of MMP and TIMP. The influence of human stromal tissues (peritoneum, myometrium, ovary) on the secretion of MMPs and TIMPs was examined by addition of these stromal tissues culture medium to human ovarian cancer cells (SAOV). All conditioned medium of stromal tissues could increase in both MMP-2, MMP-9, TIMP-1, and TIMP-2 activity in SAOV cells. Fraction (> 100kD) of conditioned medium of peritoneum could increase remarkably in MMP-9, and this increase could be inhibited by anti alpha 5 antibody, which is the most popular receptor of fibronectin. Furthermore, the addition of fibronectin to SAOV cells induced increase in the secretion of MMP-9. These results demonstrated that one of the factors included in conditioned medium of peritoneum was fibronectin. We found that interferon beta could suppressed the secretion of MMP-2 and invasion in choriocarcinoma cells. However, no effect of interferon beta was observed in SAOV cells. Several flavonoids were screened to have ability to suppress the secretion of MMPs. All trans retinoic acid (RA) could suppress the secretion of MMPs in SAOV cells in time and concentration dependent manners. Further, RA could inhibited the invasion of SAOV cells by invasion assay using boyden chamber coated with matrigel.
Star-Branched Polymers. 2. The Reaction of Dienyllithium Chains with the Isomers of Divinylbenzene (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStar-Branched Polymers. 2. The Reaction of Dienyllithium Chains with the Isomers of DivinylbenzeneR. N. Young and L. J. FettersCite this: Macromolecules 1978, 11, 5, 899–904Publication Date (Print):September 1, 1978Publication History Published online1 May 2002Published inissue 1 September 1978https://pubs.acs.org/doi/10.1021/ma60065a011https://doi.org/10.1021/ma60065a011research-articleACS PublicationsRequest reuse permissionsArticle Views203Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluating the Advisory Flags and Machine Scoring Difficulty in the <i>e‐rater</i>® Automated Scoring Engine (2016)

Abstract Successful detection of unusual responses is critical for using machine scoring in the assessment context. This study evaluated the utility of approaches to detecting unusual responses in automated essay scoring. Two research questions were pursued. One question concerned the performance of various prescreening advisory flags, and the other related to the degree of machine scoring difficulty and whether the size of the human–machine discrepancy could be predicted. The results suggested that some advisory flags operated more consistently across measures and tasks in detecting responses that the machine was likely to score differently from human raters than did other flags, and relatively little scoring difficulty was found for three of the four tasks examined in this study, with the relationship between machine and human scores being reasonably strong. Limitations and future studies are also discussed.
George Steiner, Diez (Posibles) Razones para la Tristeza Del Pensamiento, trad. María Condor (2019)

Reseña del libro, Diez (Posibles) Razones para la Tristeza Del Pensamiento, trad. María Condor, Fondo de Cultura Económica/Siruela, México, 2007, 85 pp., ISBN 978-968- 16-8402-0.
ChemInform Abstract: THE SYNTHESIS OF 2,5‐DIAMINO‐6‐HYDROXY‐1,2,3,4‐TETRAHYDRO‐1‐NAPHTHALENOL DERIVATIVES (1978)

Abstract Ausgehend von dem Methoxytetralon (Ia) werden auf dem im Formelschema angegebenen Weg die Aminotetralole (VII) und (VIII) erhalten.
Dynamically Updatable Ternary Segmented Aging Bloom Filter for OpenFlow-Compliant Low-Power Packet Processing (2018)

OpenFlow, the main protocol for software-defined networking, requires large-sized rule tables and frequent updating. For fast packet processing, rule tables are often implemented with ternary content-addressable memory (TCAM) in the OpenFlow. To deal with TCAM power problems, many network applications employ bloom filters (BFs) to reduce the redundant operations of table-lookup and for low power consumption. However, applying traditional BFs to an OpenFlow switch leads to problems, such as unsupported dynamic update, large space overhead, and the rule-set expansion of ternary data. In this paper, we propose a dynamically updatable ternary segmented aging bloom filter (TSA-BF). The TSA-BF consists of two parts: a segmented aging BF algorithm (SA-BF) and a ternary prefix-tagging encoder (TPE). First, in the SA-BF, we develop an automatic update scheme using the mechanisms of content-aging and buffer-segmenting. The SA-BF ages and deletes its contents automatically, thus eliminating the costly communication overhead and enabling dynamic updating. It also achieves space efficiency by the developed partial-deletion mechanism. Second, in the TPE, we encode ternary prefix-rules into uniquely decodable binary code words. The TPE prevents the rule-set expansion of ternary-data in the OpenFlow environment. Simulation results show that the SA-BF alone can save 37% of space overhead, compared with state-of-the-art techniques. In an environment with the ternary prefix-rules, the TSA-BF can save another 93% of space overhead, compared with the best-performance scheme. Hence, the proposed TSA-BF is highly suited to the requirements of emerging high-performance TCAM-based packet processing in the OpenFlow, which considers dynamic update and power efficiency.
Fluorescence Properties of Calmodulin-Binding Peptides Reflect Alpha-Helical Periodicity (1987)

A basic amphiphilic alpha-helix is a structural feature common to many calmodulin-binding peptides and proteins. A set of fluorescent analogues of a very tight binding inhibitor (dissociation constant of 200 picomolar) of calmodulin has been synthesized. The fluorescent amino acid tryptophan has been systematically moved throughout the sequence of this peptide. The fluorescence properties for the peptides repeat every three to four residues and are consistent with the periodicity observed for an alpha-helix.
NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL (2008)

Heterodimerization domain (HD) mutations in NOTCH1 induce ligand-independent activation of the receptor and contribute to the pathogenesis of one-third of human T-cell lymphoblastic leukemias (T-ALLs). Here we report a novel class of activating mutations in NOTCH1 leading to aberrant activation of NOTCH1 signaling in T-cell lymphoblasts. These so-called juxtamembrane expansion (JME) alleles consist of internal duplication insertions in the vicinity of exon 28 of the NOTCH1 gene encoding the extracellular juxtamembrane region of the receptor. Notably, structure-function analysis of leukemia-derived and synthetic JME mutants demonstrated that the aberrant activation of NOTCH1 signaling is dependent on the number of residues introduced in the extracellular juxtamembrane region of the receptor and not on the specific amino acid sequence of these insertions. JME NOTCH1 mutants are effectively blocked by gamma-secretase inhibitors and require an intact metalloprotease cleavage site for activation. Overall, these results show a novel mechanism of NOTCH1 activation in T-ALL and provide further insight on the mechanisms that control the activation of NOTCH1 signaling.
Investigating the effects of antenna directivity on wireless indoor communication at 60 GHz (1997)

This paper investigates the nature of the indoor radio channel at 60 GHz, with regard to its use for future high bit-rate broadband wireless networks. It is proposed that, for operation in the millimetre-wave indoor channel, directional antennas can be used to mitigate multipath effects, thus reducing the need for complex equalisation or multi-carrier techniques. An image based, ray-tracing prediction model is used to study the channel characteristics and to analyse the variation in received power, RMS delay spread and k-factor within a typical operating environment. The performances of different antenna combinations are investigated and narrowbeam, suitably aligned antennas are shown to reduce received delay spread for both LOS and non-LOS locations. The effects of non-optimal antenna alignment are observed, and system outage is determined for certain system design criteria. The results suggest that it will feasible to combat multipath effects using switched-beam directional antennas.
Sampling Characteristics of an Aircraft-Borne Aerosol Inlet System (2001)

When sampling aerosol particles from aircraft, the inlet system is the most critical item because it can strongly modify the number concentration, size distribution, and chemical composition of the particles. In this investigation, the authors describe a new aircraft-borne aerosol inlet and its sampling characteristics for submicrometer particle measurements in the upper troposphere and lower stratosphere. The new inlet is flown regularly on board a civil aircraft (Boeing 767 300ER) as part of the CARIBIC project. To investigate the sampling characteristics of the new inlet, a wind-tunnel study has been performed. Furthermore, particle transport losses in the sampling line have been calculated. Combining these results, an overall size-resolved inlet system sampling efficiency is given. During transport of the aerosol from the ambient environment to the measurement devices inside the aircraft, the aerosol experiences a strong heating within a few tenths of a second. To estimate the effects of this heating on the size distribution of the sampled particles, model calculations have been performed assuming the sampled particles to consist of sulfuric acid and water. The results show that a significant amount of water evaporates from the sampled particles, whereas sulfuric acid evaporation is so slow that it is negligible for particles larger than 4 nm.
Enhanced Intergrain Tunneling Magnetoresistance in Half-Metallic CrO <sub>2</sub> Films (1997)

Low-field tunneling magnetoresistance was observed in films of half-metallic CrO2 that were grown by high-pressure thermal decomposition of CrO3. High-temperature annealing treatments modified the intergrain barriers of the as-grown films through surface decomposition of CrO2 into insulating Cr2O3, which led to a threefold enhancement of the low-field magnetoresistance. This enhancement indicates the potential of this simple method to directly control the interface barrier characteristics that determine the magnetotransport properties.
Three-dimensional self-consistent simulation of interface and dopant disorders in delta-doped grid-gate quantum-dot devices (1997)

We study the influence of interface roughness and dopant disorder on the electronic and charging properties of a δ-doped Al1−xGaxAs/GaAs quantum-dot grid-gate device by computer simulation. The analysis is performed for a device unit cell at T=4.2 K by self-consistent adiabatic one-dimensional (1D) Schrödinger and 3D Poisson’s simulation, within the local density approximation. Random boundary conditions that accounts for cell-to-cell influence of disorder is considered as well. The random effect of interface roughness produces very short-ranged potential distortions over distances of the order of a monolayer, resulting in a maximum deviation of 20% in the charging energy. Sensitivity analysis of the device to both random fluctuations in the number and positioning of the dopant ions shows that dopant number variations from device to device can result in fluctuations in the charging energy of as much as 50% per dopant. Isolated acceptor point charges in the quantum well change the modes of electron confinement, giving rise to fluctuations in the charging energy of the order of 25%.
Narrow-Width Inductive Power Transfer System for Online Electrical Vehicles (2011)

A new inductive power transfer system with a narrow rail width, a small pickup size, and a large air gap for online electric vehicles is proposed in this paper. By introducing a new core structure, the orientation of the magnetic flux alternates along with the road; hence, an inductive power transfer system with a narrow rail width of 10 cm, a large air gap of 20 cm, and a large lateral displacement about 24 cm was implemented. The resonant circuit of the inductive power transfer system, driven by a current source, was fully characterized. The experimental results showed that the maximum output power was 35 kW and that the maximum efficiency was 74% at 27 kW. The proposed system was found to be adequate for electric vehicles, allowing them to drive freely on specially implemented roads by obtaining power from the buried power supply rail.
Surfactant-Free Method for the Synthesis of Poly(vinyl acetate) Masterbatch Nanocomposites as a Route to Ethylene Vinyl Acetate/Silicate Nanocomposites (2007)

Poly(vinyl acetate) (PVAc)/silicate nanocomposites have been prepared using a novel surfactant-free method comprising a copolymer of 2-(acryloxyethyl)trimethylammonium chloride (AETMC) and vinyl acetate (VAc) as the modifier for layered silicates. The nanocomposites maintained the exfoliated morphology even at silicate contents greater than 20 wt % as evidenced by the absence of peaks in the X-ray diffraction (XRD) patterns and absence of silicate bundles in the transmission electron microscopy (TEM) images. These high silicate-containing PVAc nanocomposites served as masterbatches for the preparation of ethylene vinyl acetate (EVA)/silicate nanocomposites by solution blending with EVA. A combination of XRD and TEM studies confirmed mostly exfoliated morphology for the final nanocomposites containing varying amounts of silicate. Thermogravimetric analysis (TGA) in both nitrogen and air revealed that thermal stability of the nanocomposites in air was enhanced. Dynamic mechanical analysis (DMA) of the EVA/silicate nanocomposites over a temperature range of −70 to 50 °C showed that the storage moduli of the nanocomposites above the glass transition temperature were higher than those of the pure EVA and the corresponding intercalated EVA/silicate nanocomposites. The improvement in storage modulus of the nanocomposites was attributed to the exfoliated morphology and synergistic effect of both the PVAc copolymer and the silicate. Thus, the EVA nanocomposite containing 5 wt % silicate showed a storage modulus fourfold higher than that of pure EVA and twofold higher than that of EVA/PVAc blend.
Compensating for eye tracker camera movement (2006)

An algorithm was developed to improve prediction of eye position from video-based eye tracker data. Eye trackers that determine eye position relying on images of pupil and corneal reflection positions typically make poor differentiation between changes in eye position and movements of the camera relative to the subject's head. The common method employed by video-based eye trackers to determine eye position involves calculation of the vector difference between the center of the pupil and the center of the corneal reflection under the assumption that the centers of the pupil and the corneal reflection change in unison when the camera moves with respect to the head. This assumption was tested and is shown to increase prediction error. Also, predicting the corneal reflection center is inherently less precise than that of the pupil due to the reflection's small size. Typical approaches thus generate eye positions that can only be as robust as the relatively noisy corneal reflection data. An algorithm has been developed to more effectively account for camera movements with respect to the head as well as reduce the noise in the final eye position prediction. This algorithm was tested and is shown to be particularly robust during the common situation when sharp eye movements occur intermixed with smooth head-to-camera changes.
Development of the hypochord and dorsal aorta in the zebrafish embryo Danio rerio (2000)

ABSTRACT The hypochord of the zebrafish embryo (Danio rerio) emerges at the 9-somite stage as a single row of cells in the dorsomedial endoderm immediately ventral to the notochord. It is recognizable from the 2nd or 3rd somite and extends along the trunk to the same extent as the somites. A basal lamina surrounds the hypochord and its cells are slightly larger than the nearby endoderm cells. TEM studies have shown that the hypochord cells contain, in addition to mitochondria, well-developed rough endoplasmic reticula and Golgi networks, indicating synthetic activity. Once formed, the hypochord will stay in close association with the notochord, and this axial complex gradually moves dorsally, separating the hypochord from the endoderm as a one-cell-wide, rod-like structure that is bean-shaped in transverse section. This is the situation in the 15-somite embryo, at the level of the 4–5th somites. In the gap between the hypochord and the endoderm, angioblast cells aggregate and start to form the dorsal aorta, which becomes intimately associated with the hypochord. In the 17-somite embryo the aortic rudiment is established just ventral to the hypochord as a tube with a lumen. As development proceeds, the size of the hypochord decreases. In the pec fin embryo the hypochord is still recognizable in the posterior trunk, but has apparently vanished in anterior regions. The temporal correlation between the appearance of the hypochord and the formation of the dorsal aorta, coupled with the intimate relationship between these structures, suggest that the hypochord may play a role in the positioning of the dorsal aorta. J. Morphol. 244:167–176, 2000 © 2000 Wiley-Liss, Inc.
High aspect ratio etching of nanopores in PECVD SiC through AAO mask (2013)

We present in this work the fabrication of high aspect ratio nanopores in 500 nm PECVD SiC films through AAO (anodic aluminum oxide) mask. The initial AAO thin film is 180 nm thick and the diameter of nanopores is 33 ± 7 nm. We have used three plasma chemistries: CF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> , Cl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Ar, and SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> /O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> to study the pattern transfer process into SiC at sub-50 nm scale by deep reactive ion etching. CF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> and Cl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Ar etchings show highly anisotropic features. Vertical pores with similar diameter as the AAO mask (33 ± 12 nm) and as deep as 400 nm (aspect ratio > 10) can be achieved by CF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> reactant. As comparison, SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> /O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> chemistry generates very different etching profiles, causing trenches both in vertical and lateral directions. Our PECVD SiC nanopores are promising candidates for robust biosensing and nanofiltration applications.
Dynamics of Autohumidifed PEM Fuel Cell Operation (2006)

Start-up and dynamic responses to changes in load are reported for a dry feed, autohumidified polymer electrolyte membrane fuel cell (PEMFC). The fuel cell current can be ignited by water injection; criteria are derived for the required water injection as functions of fuel cell size, temperature, and reactant feed rates. Steady-state multiplicity is observed where the fuel cell current can be either high ("ignited") or low ("extinguished") with the same flow rates, temperature, pressure, and load. Different steady-state voltages were obtained for the same current depending on the operational history. The steady-state multiplicity results from a positive feedback between the membrane resistance and water production. Membrane water content is determined from the balance of water produced and water removed by convection. Current ignition occurs when the water produced is greater than its removal, hydrating the membrane; current extinction occurs when the water produced is less than its removal, which dehydrates the membrane. Through the use of mass balances and constitutive equations, design criteria are obtained for sizing and operating autohumidified PEMFCs.