gebhart/patrepeval huggingface dataset:
Determination of naphthenic acids in California crudes and refinery wastewaters by fluoride ion chemical ionization mass spectrometry (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of naphthenic acids in California crudes and refinery wastewaters by fluoride ion chemical ionization mass spectrometryIsmet. Dzidic, A. C. Somerville, J. C. Raia, and H. V. HartCite this: Anal. Chem. 1988, 60, 13, 1318–1323Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ac00164a015https://doi.org/10.1021/ac00164a015research-articleACS PublicationsRequest reuse permissionsArticle Views392Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein (2008)

The trafficking of normal cellular prion protein (PrPC) is believed to control its conversion to the altered conformation (designated PrPSc) associated with prion disease. Although anchored to the membrane by means of glycosylphosphatidylinositol (GPI), PrPC on neurons is rapidly and constitutively endocytosed by means of coated pits, a property dependent upon basic amino acids at its N-terminus. Here, we show that low-density lipoprotein receptor-related protein 1 (LRP1), which binds to multiple ligands through basic motifs, associates with PrPC during its endocytosis and is functionally required for this process. Moreover, sustained inhibition of LRP1 levels by siRNA leads to the accumulation of PrPC in biosynthetic compartments, with a concomitant lowering of surface PrPC, suggesting that LRP1 expedites the trafficking of PrPC to the neuronal surface. PrPC and LRP1 can be co-immunoprecipitated from the endoplasmic reticulum in normal neurons. The N-terminal domain of PrPC binds to purified human LRP1 with nanomolar affinity, even in the presence of 1 muM of the LRP-specific chaperone, receptor-associated protein (RAP). Taken together, these data argue that LRP1 controls both the surface, and biosynthetic, trafficking of PrPC in neurons.
Electioneering: Vietnamese Style (1962)

Research Article| November 01 1962 Electioneering: Vietnamese Style Nguyen Tuyet Mai Nguyen Tuyet Mai Search for other works by this author on: This Site PubMed Google Scholar Memorandum (Institute of Pacific Relations, American Council) (1933) 2 (9): 11–18. https://doi.org/10.2307/3023533 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Nguyen Tuyet Mai; Electioneering: Vietnamese Style. Memorandum (Institute of Pacific Relations, American Council) 10 May 1933; 2 (9): 11–18. doi: https://doi.org/10.2307/3023533 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAsian Survey Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
On the optimality of parsing in dynamic dictionary based data compression (1999)

This paper considers the following question: once a (dynamic) dictionary construction scheme is selected, is there an efficient dynamic parsing method that results with the smallest number of phrases possible for the selected scheme, for all input strings. It is shown that greedy parsing, a method used in almost all dictionary based algorithms (including unix compress, gif image compression, and fax and modem standards), can be far from optimal for certain input strings. On the positive side, a simple parsing method is introduced which, for any selected dictionary scheme which has the prefix property (this includes virtually all the variations on Lempel-Ziv algorithms), is optimal with respect to the selected scheme for any input string. Also introduced is a simple data structure that enables an efficient dynamic implementation of the parsing method, in O(1) time per character and optimal space requirement.
Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer (2004)

Tumor tissues and adjacent normal tissues in 12 colorectal cancers were examined for quantitative differences in: i) activity of DNA-dependent protein kinase (DNA-PK), which functions in DNA double-strand breads repair, and ii) protein and mRNA levels of Ku70, Ku80, DNA-PKcs and transcriptional factor Sp1. DNA-PK activity and protein/mRNA levels of Ku70, Ku80, DNA-PKcs and Sp1 were significantly higher in the tumor tissues compared with the normal tissues. Significant correlations between DNA-PK activity and protein/mRNA levels of Ku70, Ku80, DNA-PKcs and Sp1 were observed. Because Ku80 and DNA-PKcs have consensus Sp1 recognition elements in their promoter region, the DNA sequence of Ku70 promoter region was analyzed. Analysis of Ku70 promoter region reveled that Ku70 gene has consensus Sp1 recognition elements in its promoter region. mRNA levels of Ku70, Ku80 and DNA-PKcs were correlated with one another, and significant correlations between Sp1 protein level and mRNA levels of Ku70 and Ku80 were observed. These results suggest that DNA-PK activity and protein- and mRNA-levels of Ku70, Ku80 and DNA-PKcs were elevated in tumor tissues in patients with colorectal cancer because of elevated Sp1 protein levels in tumor tissues.
Acute inflammation (1991)

It is well documented in animal and human research that unaccustomed eccentric muscle action of sufficient intensity and/or duration causes disruption of connective and/or contractile tissue. In humans, this appears to be associated with the sensation of delayed onset muscle soreness (DOMS). During the late 1970's, it was proposed that this sensation of soreness might be associated with the acute inflammatory response. However, subsequent research failed to substantiate this theory. The present article suggests that the results of much of the research concerning DOMS reflect events typically seen in acute inflammation. Similarities between the two events include: the cardinal symptoms of pain, swelling, and loss of function; evidence of cellular infiltrates, especially the macrophage; biochemical markers such as increased lysosomal activity and increased circulating levels of some of the acute phase proteins; and histological changes during the initial 72 h. In the final section of this paper, a theoretical sequence of events is proposed, based on research involving acute inflammation and DOMS.
A novel p21 attenuator which is structurally related to sorafenib (2013)

p21 is a member of the cyclin kinase inhibitor family of proteins and plays pivotal roles in cellular proliferation as well as in the regulation of apoptosis, and thus has diverse functions in diseases as varied as cancer and atherosclerosis. In light of its pleiotropic effects and potential clinical relevance, new methods of attenuation of p21 protein levels by selective inhibitors are therefore powerful tools to probe malignant, infectious and other diseases. Here we introduce a novel p21 attenuator, UC2288, which possesses consistent and relatively selective activity for p21. UC2288 was synthesized based on the chemical model of sorafenib, a multikinase inhibitor that also attenuates p21, but unlike sorafenib, UC2288 did not inhibit Raf kinases or alter p-ERK protein levels. UC2288 decreased p21 mRNA expression independently of p53, and attenuated p21 protein levels with minimal effect on p21 protein stability. In addition, UC2288 inhibits cell growth in the kidney cancer cell lines (GI50 = approximately 10 µM) as well as multiple other cancer cell lines. Thus, this novel p21 inhibitor will be indispensable for exploring the function of p21, and upon further study may be translatable to the clinic.
Dysplastic Nevus Syndrome (1984)

AbstractAn almost fortuitous discovery of a close association between a familial subtype of malignant melanoma and the dysplastic nevus syndrome not only has facilitated early diagnosis and cure of some melanomas but has provided oncologists with a highly useful and observable human model for studying evolution of malignant diseases from premalignant precursors.
Rotating field collector subsystem Phase I study and evaluation (1982)

The rotating field collector system is an alternative concept in which all heliostats are mounted on a single large platform which rotates around a tower to track the azimuthal angle of the sun. Each heliostat is mounted to the platform with appropriate pivots, linkage, and controls to provide the additional positioning required to properly direct the solar radiation onto the receiver. The results are presented of the first phase of a study to investigate the technical and economic merits of a particular type of rotating field collector subsystem. The large pie-shaped platform would revolve over an array of support pedestals by means of a roller at the top of each pedestal. Several heliostats were built to demonstrate their construction features, and the operation of both flat and amphitheater rotating fields was studied. Work included an analysis of the concepts, development of modifications and additions to make the system comply with design criteria, and cost estimates to be used for comparison with other heliostat subsystems. Because of considerably high cost estimates, the focus of a large part of the study was directed toward developing lower cost designs of major components. (LEW)
[Medical application of nano-materials]. (2002)

The application of Nanotechnology will play important roles in clinical medicine, wound repair and basic research for the traditional Chinese medicine.
Core-scale experimental study of relative permeability properties of CO2 and brine in reservoir rocks (2009)

Experimental studies of both drainage and imbibition displacements are needed to improve our fundamental understanding of multi-phase flow and trapping in CO2-brine systems and effectively take advantage of the large storage capacity of saline aquifers. Very few relative permeability measurements have been made and even fewer with in situ saturation measurements. Two new sets of steady state relative permeability measurements have been made in two different rock samples, and over a range of injection flow rates. These studies show that multi-phase brine displacement efficiency is strongly affected by the heterogeneity of the core. Moreover, we observe that, at any given fractional flow, different flow rates result in different CO2 saturations. Similarly, different flow rates lead to different relative permeability curves. Numerical simulations of two phase displacement are performed on one sample, and at one fractional flow of CO2. Numerical simulations demonstrate that some of the features of the saturation distributions can be qualitatively replicated. However, improvements in the correlations between porosity, saturation and capillary pressure will be needed to replicate the saturation distributions measured in the experiments.
Identification of phase-specific antigenic fractions of Coxiella burnetti by enzyme-linked immunosorbent assay (1986)

Antigenic fractions of Coxiella burnetii phase variants were identified with an enzyme-linked immunosorbent assay (ELISA). Immune sera from guinea pigs immunized with Formalin-inactivated phase I or phase II whole cells were used to measure the antigenic activity of whole cells and various soluble and particulate preparations. Phase-specific antigens of C. burnetii whole cells and fractions were compared by dose-response curves at different (antigen and antibody) dilutions. Water-soluble extracts prepared by meta-periodate, ether, and phenol extraction of phase I whole cells yielded antigenic fractions which reacted with anti-phase I antibodies. The extraction of phase I whole cells with dimethyl sulfoxide, trichloracetic acid, and Formalin yielded antigenic fractions which detected antibodies in both anti-phase I and -phase II sera. Interestingly, the trichloracetic acid extract of phase I whole cells also contained a component which bound nonimmune immunoglobulin. The sera of animals immunized with whole cells of the phase II Australian QD strain reacted with lipopolysaccharides of the phase I and phase II Nine Mile strains. Therefore, variations in lipopolysaccharide structure among phase variants of C. burnetii were detected as cross-reactions with immune sera from an interspecific strain. Comparisons of immunofluorescence, microagglutination, and the complement fixation assays with the ELISA indicated greater sensitivity and specificity of the ELISA for the measurement of phase-specific antigens and antibodies.
Landowner Attitudes Toward Introduced Wild Turkeys in Northwestern Minnesota (2012)

Wild turkeys (Meleagris gallopavo) were introduced to northwestern Minnesota, USA, in 2006 and 2007. This provided an opportunity to examine landowner feelings for a wildlife species not endemic to the region. In 2007, we mailed surveys to 200 landowners to evaluate landowner interactions, feelings, and concerns with turkeys. Overall response rate was 76%. Eighty-nine percent of respondents in northwestern Minnesota reported positive feelings toward turkeys, 9% were indifferent, and 2% reported negative feelings. The introduced turkeys were not perceived to be problematic:
Matrix metalloproteinases in development and disease (2006)

Matrix metalloproteinases (MMPs) are key modulators of many biological processes during pathophysiological events, such as skeletal formation, angiogenesis, cellular migration, inflammation, wound healing, coagulation, lung and cardiovascular diseases, arthritis, and cancer. Twenty-four members of the MMP family have been identified in humans, degrading many components of the extracellular matrix, cellular receptors, and cytokines. This review describes the molecular structure, activation and inhibition, and substrate specificity of MMPs, and their biological function in development and disease.
An implementation of time synchronization in low-power wireless sensor networks (2011)

Time synchronization plays an important role in wireless sensor networks, enabling correlation of diverse measurements from distributed sensor nodes, shared channel communication, and energy conservation. When designing time synchronization algorithms for wireless sensor networks, a number of parameters needs to be carefully considered, including precision, processing time overheads, memory requirements, and energy costs. In this paper we describe an implementation of time synchronization on a wireless sensor network custom designed for traffic monitoring applications. Each node consists of a magnetic sensor, a microcontroller, and a low-power Nordic nRF24L01+ radio chip. We describe various aspects of our time synchronization implementation, including hardware interfacing, low-level event time-stamping, time synchronization mechanism, and software implementation. We discuss the results of our experimental study focusing on precision and performance overhead.
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions (2012)

Many cellular responses during development are regulated by interactions between integrin receptors and extracellular matrix proteins (ECMPs). Although the majority of recent studies in human embryonic stem cell (hESC) differentiation have focused on the role of growth factors, such as FGF, TGFβ, and WNT, relatively little is known about the role of ECMP-integrin signaling in this process. Moreover, current strategies to direct hESC differentiation into various lineages are inefficient and have yet to produce functionally mature cells in vitro. This suggests that additional factors, such as ECMPs, are required for the efficient differentiation of hESCs. Using a high-throughput multifactorial cellular array technology, we investigated the effect of hundreds of ECMP combinations and concentrations on differentiation of several hPSC lines to definitive endoderm (DE), an early embryonic cell population fated to give rise to internal organs such as the lung, liver, pancreas, stomach, and intestine. From this screen we identified fibronectin (FN) and vitronectin (VTN) as ECMP components that promoted DE differentiation. Analysis of integrin expression revealed that differentiation toward DE led to an increase in FN-binding integrin α5 (ITGA5) and VTN-binding integrin αV (ITGAV). Conditional short hairpin RNA-mediated knockdown of ITGA5 and ITGAV disrupted hESC differentiation toward DE. Finally, fluorescence-based cell sorting for ITGA5 and ITGAV significantly enriched cells with gene expression signatures associated with DE, demonstrating that these cell surface proteins permit isolation and enrichment of DE from hESCs. These data provide evidence that FN and VTN promote endoderm differentiation of hESCs through interaction with ITGA5 and ITGAV, and that ECMP-integrin interactions are required for hESC differentiation into functionally mature cells.
Cysteine as an inhibitor of enzymic browning. 1. Isolation and characterization of addition compounds formed during oxidation of phenolics by apple polyphenol oxidase (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCysteine as an inhibitor of enzymic browning. 1. Isolation and characterization of addition compounds formed during oxidation of phenolics by apple polyphenol oxidaseFlorence C. Richard, Pascale M. Goupy, Jacques J. Nicolas, Jean Michel Lacombe, and Andre A. PaviaCite this: J. Agric. Food Chem. 1991, 39, 5, 841–847Publication Date (Print):May 1, 1991Publication History Published online1 May 2002Published inissue 1 May 1991https://pubs.acs.org/doi/10.1021/jf00005a004https://doi.org/10.1021/jf00005a004research-articleACS PublicationsRequest reuse permissionsArticle Views880Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deep-Ultraviolet Nonlinear-Optical Material K<sub>3</sub>Sr<sub>3</sub>Li<sub>2</sub>Al<sub>4</sub>B<sub>6</sub>O<sub>20</sub>F: Addressing the Structural Instability Problem in KBe<sub>2</sub>BO<sub>3</sub>F<sub>2</sub> (2017)

A beryllium-free deep-ultraviolet (DUV) nonlinear-optical (NLO) material, K<sub>3</sub>Sr<sub>3</sub>Al<sub>4</sub>Li<sub>2</sub>B<sub>6</sub>O<sub>20</sub>F, has been synthesized and characterized. Unlike KBe<sub>2</sub>BO<sub>3</sub>F<sub>2</sub> (KBBF), the reported NLO material does not require the use of toxic BeO in the synthesis, and through the judicious selection of cations, strong interlayer interactions are observed that facilitate the crystal growth. K<sub>3</sub>Sr<sub>3</sub>Al<sub>4</sub>Li<sub>2</sub>B<sub>6</sub>O<sub>20</sub>F exhibits second-harmonic generation (SHG) at both 1064 and 532 nm with efficiencies of 1.7KH<sub>2</sub>PO<sub>4</sub> and 0.3β-BaB<sub>2</sub>O<sub>4</sub> and has an absorption edge of 190 nm. Because of the strong interlayer interactions, we were able to grow well-faceted large crystals, 8 × 8 × 5 mm<sup>3</sup>, through a top-seeded-solution-growth technique. With these crystals, we determined a birefringence of 0.0574 at 1064 nm and a type I phase-matching SHG limit of 224 nm.
A Dual-Band Dual-Polarised Stacked Patch Antenna for 28 GHz and 39 GHz 5G Millimetre-Wave Communication (2019)

Rapid developments in wireless communications demand an antenna that can operate at dual frequency bands in a compact size. In this work, a dual-band dual-polarised antenna is proposed for future 5G wireless communications that can operate at 28 GHz and 39 GHz 5G frequency bands. The proposed antenna is a stacked capacitive coupled patch antenna with bend parasitic elements having a dual-polarisation capability. The design principles and the antenna performance are discussed in detail. The antenna covers 25.75-30.25 GHz and 36.5-41.5 GHz and has a broad bandwidth in both the frequency bands. The proposed antenna element has a peak gain of 7.14 dBi in the lower band and 6.44 dBi in the higher band. The antenna element has a compact size of 3.8 mm × 3.8 mm × 1 mm making it suitable for implementation of antenna arrays in mobile devices.