gebhart/patrepeval huggingface dataset:
Fatty acyl amidases from Dictyostelium discoideum that act on lipopolysaccharide and derivatives. II. Aspects of substrate specificity. (1982)

The substrate specificities of two fatty acyl amidases partially purified from the slime mold Dictyostelium discoideum have been studied. The amidase act on lipopolysaccharide derivatives, such as (4'-O-phosphoryl-N-beta-hydroxymyristyl-D-glucosaminyl)-beta-(1 leads to 6)-N-beta-hydroxymyristyl-D-glucosamine-1-phosphate (III) in a sequential manner. Amidase-I removes the beta-hydroxymyristyl residue present on the amino group adjacent to the 1-phosphate and the product formed is a substrate for amidase-II; the latter removes the remaining beta-hydroxymyristyl residue from the distal amino group. Compound III itself is resistant to amidase-II. Removal of the C-1 or C-4 phosphate groups does not influence recognition by the amidases or their sequential action. Both amidases are specific for long chain fatty amide linkages. Thus, a formyl group on the glucosamine amino group adjacent to the C-1 phosphate is not hydrolyzed by amidase-I; however, this substituent does not hinder the action of amidase-II on the distal fatty acyl amide. The presence of the beta-hydroxyl group in myristyl-amide residues is not required for hydrolysis. Further, while amidase-I requires disaccharide structures for its action, amidase-II acts on monosaccharides as well. Finally, the effects of a variety of substrate analogs and divalent ions on the activity of the enzymes are reported.
The Cognitive Failures Questionnaire (CFQ) and its correlates (1982)

This paper describes a questionnaire measure of self-reported failures in perception, memory, and motor function. Responses to all questions tend to be positively correlated, and the whole questionnaire correlates with other recent measures of self-reported deficit in memory, absent-mindedness, or slips of action. The questionnaire is however only weakly correlated with indices of social desirability set or of neuroticism. It is significantly correlated with ratings of the respondent by his or her spouse, and accordingly does have some external significance rather than purely private opinion of the self. The score is reasonably stable over long periods, to about the same extent as traditional measures of trait rather than state. Furthermore, it has not thus far been found to change in persons exposed to life-stresses. However, it does frequently correlate with the number of current psychiatric symptoms reported by the same person on the MHQ; and in one study it has been found that CFQ predicts subsequent MHQ in persons who work at a stressful job in the interval. It does not do so in those who work in a less stressful environment. The most plausible view is that cognitive failure makes a person vulnerable to showing bad effects of stress, rather than itself resulting from stress.
Temperature effect on carbon partitioning in two commercial cultivars of sugarcane (2010)

The effect of temperature upon plant growth and partitioning of dry matter in sugarcane (Saccharum spp.) was determined. Sugarcane plants of two commercial cultivars, Q117 and Q138 were grown under constant conditions for 72 days then subjected to one of four different ambient temperature regimes, 14, 18, 22 or 26°C. Plants were harvested before the imposition of the treatments, then at 85, 120, 155 and 190 days after planting (DAP) for biomass and sugar partitioning. Following the imposition of temperature treatments, the increase in stalk length and node number was linear and notably different between the temperature regimes for both cultivars. When the data was described in terms of thermal time (growth temperature (°C) × number of days), the number of internodes produced per unit of thermal time was the same irrespective of the temperature in which the plants were grown and internode number increased in a linear manner with an increase in total thermal input. Stalk dry matter accumulation over time was linear at the log-scale and highly significant, (P &lt; 0.001) for both Q117 and Q138. The linear rate of accumulation increased with temperature ranging from 1.39 g day–1 at 14°C to 5.31 g day–1 at 26°C for Q117, whereas in Q138 it ranged from 2.24 g day–1 to 4.39 g day–1 at temperatures of 14 and 26°C, respectively. The pattern of total sucrose accumulation also followed an exponential trend, with little difference evident until 155 DAP where rates increased with temperature for both varieties. However, the increase between 14 and 26°C was more profound for Q117. The sucrose/hexose ratio also differed between the cultivars. This difference was most pronounced in plants grown at both 14 and 18°C where the ratio of sucrose/hexose in Q117 was double that measured in Q138. The production of phytomeric units in sugarcane is clearly a function of accumulated degree-days and influenced by cultivar. The elongation of internodes is influenced by temperature and varietal interaction but is not a function of degree-days.
Analysis of Corrosion Processes at the Surface of Diamond-Like Carbon Protected Zinc Selenide Waveguides (2004)

A detailed surface analytical study on the corrosion behavior of unprotected and diamond-like carbon (DLC)-coated mid-infrared (MIR) waveguides used in remote sensing applications at strongly oxidizing conditions is presented. High-quality DLC films, with a thickness of 100 nm serving as MIR-transparent corrosion barrier, have been produced at the surface of zinc selenide (ZnSe) attenuated total reflection waveguides via pulsed laser deposition techniques. IR microscopy and atomic force microscopy are applied to investigate the chemical inertness of DLC-based membranes against aqueous solutions of hydrogen peroxide. These stability studies show that uncoated ZnSe waveguides are subject to severe chemical surface modifications, while DLC-protected waveguides maintain their optical properties and chemical integrity. In situ studies on the corrosion behavior by a recently developed approach combining scanning electrochemical microscopy (SECM) with Au/Hg amalgam ultramicroelectrodes in a scanning stripping voltammetry experiment provides additional insight into the mechanisms of the corrosion process. It is demonstrated that the combination of surface analytical techniques and, in particular, the innovative application of SECM with amalgam electrodes provides superior information on corrosion processes at the surface of optical waveguides. This detailed study confirms the efficiency of protective DLC coatings deposited onto IR-transparent optical waveguides, rendering this novel concept ideal for sensing applications in harsh environments.
Notes on Breeding Activities and on Gular Sacs in the Pine Grosbeak (1954)

Notes on Breeding Activities and on Gular Sacs in the Pine Grosbeak Get access Norman R. French Norman R. French Division of Biology, University of Utah, Salt Lake City, Utah Search for other works by this author on: Oxford Academic Google Scholar The Condor, Volume 56, Issue 2, 1 March 1954, Pages 83–85, https://doi.org/10.2307/1364663 Published: 01 March 1954
Diagnóstico salivar mediante nanotecnología, proteómica y genómica (2006)

Antecedentes. La capacidad de monitorizar el estado, la aparicion y progreso de la enfermedad, y los resultados del tratamiento, por medios no invasivos, es un objetivo altamente deseable en la promocion y oferta sanitaria a los ciudadanos. El fluido oral es un medio ideal a considerar para el seguimiento de la salud y de las enfermedades. Metodos. Se dan dos requisitos previos al logro del objetivo del diagnostico salivar identificacion de biomarcadores especificos asociados con un estado particular de salud o enfermedad y desarrollo de las tecnologias que pueden discriminar entre los biomarcadores. Una iniciativa reciente del National Institute of Dental and Craniofacial Research (Instituto Nacional de Investigacion Dental y Craneofacial) ha establecido una hoja de ruta para poder alcanzar dichos objetivos por medio del uso de los fluidos orales como medio de analizar el estado de salud y/o enfermedad del paciente. Ello ofrece una oportunidad ideal para optimizar los biosensores de vanguardia basados en saliva que muestran diferencias entre las distintas enfermedades. Resultados. Siete grupos tecnologicos estan desarrollando diferentes tecnologias de diagnostico salivar a utilizar en el centro de asistencia. Tres grupos trabajan conjuntamente para llegar a descifrar el PROTEOME salivar. Conclusion. Estos esfuerzos colectivos junto con la convergencia de las tecnologias de diagnostico salivares y el PROTEOMA salivar resultaran en oportunidades sin parangon en la exploracion del potencial diagnostico de la saliva en las enfermedades orales y sistemicas. Palabras clave. Fluido oral, saliva, cancer oral, nanotecnologia, proteomica, genomica.
Magnetostatic Wave Frequency Selective Limiters (2013)

Frequency selective limiters (FSLs), which selectively attenuate above threshold signals while allowing low power signals to pass with little attenuation, have potential application in maintaining the dynamic range of RF receivers in the presence of interference. Stripline FSLs, fabricated using thick yttrium iron garnet (YIG) films, are suitable for broadband, microwave applications but have typical threshold power levels of 0 dBm which is too high for many RF applications. Here magnetostatic wave (MSW) FSLs are described with frequency selectivity and threshold power levels at least 10 times lower than achieved with stripline devices. The performance of an MSW FSL operating in the UHF band will be presented and compared with a model for threshold power. Based on these results the performance limits of FSLs will be discussed with emphasis on reducing threshold power levels significantly below -40 dBm as required in potential GPS applications.
The transannular electrophilic reaction of alkenyl nitroso compounds and the stereochemistry of nitrosyl chloride addition (1979)

Nitrosyl chloride reacted with 1,5-cyclooctadiene and trans,trans,trans-1,5,9-cyclododecatriene in methylene chloride by the cis-addition to give chloronitroso alkenes with cis and threo (trans) configuration, respectively. These enantiomorphic C-nitroso compounds were isolated as a single compound for the former, and a mixture for the latter, of dl and (or) meso dimers, the presence of which was readily monitored by 13 C nmr spectroscopy. The former can assume a conformation to place the π-bonds of the nitroso and olefinic groups in interacting vicinity and undergo an acid catalyzed intramolecular electrophilic cyclization to give bicyclic hydroxylamines which are readily air oxidized to the corresponding nitroxide radicals. Rearrangement in acetic anhydride – methylene chloride afforded good yields of the stable bicyclic hydroxyl-amine acetates which served as precursors to generate the corresponding nitroxides under mild conditions. Photoaddition of N-nitrosopiperidine to 1,5-cyclooctadiene also partly afforded the cis-aminonitroso adduct which underwent the intramolecular addition to give hydroxylamines. The threo(trans)-chloronitroso alkenes failed to cyclize in similar fashion under comparable conditions. Nitrosylchloride added exclusively to the trans-double bond of trans,cis-1,5-cyclo- decadiene without regiospecificity but was believed to follow the stereospecific cis-addition; this chloronitroso compound also underwent the acid catalyzed transannular reaction to give similar hydroxylamines that were not isolated in pure states.
Efficient and Dynamic Simplification of Line Drawings (2008)

Abstract In this paper we present a pipeline for rendering dynamic 2D/3D line drawings efficiently. Our main goal is to create efficient static renditions and coherent animations of line drawings in a setting where lines can be added, deleted and arbitrarily transformed on‐the‐fly. Such a dynamic setting enables us to handle interactively sketched 2D line data, as well as arbitrarily transformed 3D line data in a unified manner. We evaluate the proximity of screen projected strokes to simplify them while preserving their continuity. We achieve this by using a special data structure that facilitates efficient proximity calculations in a dynamic setting. This on‐the‐fly proximity evaluation also facilitates generation of appropriate visibility cues to mitigate depth ambiguities and visual clutter for 3D line data. As we perform all these operations using only line data, we can create line drawings from 3D models without any surface information. We demonstrate the effectiveness and applicability of our approach by showing several examples with initial line representations obtained from a variety of sources: 2D and 3D hand‐drawn sketches and 3D salient geometry lines obtained from 3D surface representations.
Visualisation and analysis of proteomic data from the procyclic form of <b> <i>Trypanosoma brucei</i> </b> (2005)

We have undertaken a large scale study of the proteins expressed in the procyclic form of the parasite Trypanosoma brucei, which causes African sleeping sickness, using 2-DE and MS. The complete data set encompasses over 2000 identifications, of which 770 are distinct proteins. We have discovered that multiple protein isoforms appear to be common in T. brucei, as most proteins have been matched to more than one gel spot. We have developed visualisation software to investigate the differences between isoforms, based on the information from the results of database searches with MS data. We are able to highlight instances where PTMs are the most likely cause of variant forms. In other cases, spots that appear reproducibly across replicates contain fragments of proteins, arising either as experimental artefacts or as part of protein degradation. We are also able to classify clusters of gel spots into different groups based on the pattern of peptides that have been matched from MS data. The entire data set is stored within a relational database system that allows complex queries ( http://www.gla.ac.uk/functionalgenomics). Using specific proteins as examples, we demonstrate how the visualisation software and the database query facilities can be used.
Activation of NF‐κB by ER stress requires both Ca<sup>2+</sup> and reactive oxygen intermediates as messengers (1996)

The eukaryotic transcription factor NF-kappaB is activated by a large variety of stimuli. We have recently shown that ER stress, caused by an aberrant accumulation of membrane proteins within this organelle, also activates NF-kappaB. Here, we show that activation of NF-kappaB by ER stress requires an increase in the intracellular levels of both reactive oxygen intermediates (ROIs) and Ca2+. Two distinct intracellular Ca2+ chelators and a panel of structurally unrelated antioxidants prevented NF-kappaB activation by various ER stress-eliciting agents, whereas only antioxidants but not the Ca2+ chelators prevented NF-kappaB activation by the inflammatory cytokine TNF-alpha. Consistent with an involvement of calcium, the ER-resident Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid (CPA), which trigger a rapid efflux of Ca2+ from the ER, also potently activated NF-kappaB. Pretreatment with a Ca2+ chelator abrogated this induction. The Ca2+ chelator BAPTA-AM inhibited ROI formation in response to thapsigargin and CPA treatment, suggesting that the Ca2+ increase preceded ROI formation during NF-kappaB activation. The selective inhibitory effect of the drug tepoxalin suggests that the peroxidase activity of cyclooxygenases or lipoxygenases was responsible for the increased ROI production in response to Ca2+ release by thapsigargin.
<scp>XIV</scp>. Yeast sequencing reports. The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from <i>Saccharomyces cerevisiae</i> (1995)

We have determined the complete nucleotide sequence of a 44 420 bp DNA fragment from chromosome XIV of Saccharomyces cerevisiae. The sequence data revealed 23 open reading frames (ORFs) larger than 300 bp, covering 73.5% of the sequence. The ORFs N2418, N2428, N2441, N2474 and N2480 correspond to previously sequenced S. cerevisiae genes coding respectively for the mitochondrial import protein Mas5, the nucleolar protein Nop2, the outer mitochondrial membrane porin Por1, the cytochrome c oxidase polypeptide VA precursor CoxA and the yeast protein tyrosine phosphatase Msg5. Translation products of three other ORFs N2406, N2411 and N2430 exhibit similarity to previously known S. cerevisiae proteins: the ribosomal protein YL9A, the protein Nca3 involved in the mitochondrial expression of subunits 6 and 8 of the ATP synthase and actin; in addition N2505 presents strong similarity to an ORF of chromosome IX. The predicted protein products of ORFs N2417 and N2403 present similarities with domains from proteins of other organisms: the Candida maltosa cycloheximide-resistance protein, the human interleukin enhancer-binding factor (ILF-2). The 12 remaining ORFs show no significant similarity to known proteins. In addition, we have detected a DNA region very similar to the yeast transposon Ty 1-15 of which insertion has disrupted a tRNA(Asp) gene.
Postprocessing of Velocity Distributions in Real-Time Ultrasonic Color Velocity Imaging (1994)

A robust processing scheme is proposed that improves the presentation of 2-dimensional velocity distributions in real-time ultrasonic color velocity images. Essentially, the algorithm is a modification of a first order recursive filter, processing each velocity signal in the spatial distribution separately from the others. It restores the sudden holes and notches in the velocity profiles that occur whenever the observed blood velocity is incidentally close to zero. At the same time, unlike conventional persistence filters, it does not influence any of the true velocity information that is measured. The result is a consistent sequence of color velocity images with smooth transitions between the borders of the consecutive velocity profiles and with an improved definition of the regions containing blood.
Théorie dynamique de la diffraction des rayons X par les cristaux déformés (1964)

La théorie dynamique classique de la diffraction des rayons X est étendue au cas des cristaux ayant subi une déformation quelconque et des ondes non planes. La méthode consiste à résoudre les équations de Maxwell en considérant les déformations et la courbure des ondes comme des perturbations du premier ordre. On obtient ainsi un système différentiel simple dont la résolution n'est en général possible que numériquement. Une application particulière est faite au cas des cristaux courbés. On en déduit une méthode numérique simple de calcul du pouvoir réflecteur des cristaux courbés. Le résultat de mesures absolues est en bon accord avec la théorie. On expose ensuite une méthode approximative de calcul de l'augmentation du pouvoir réflecteur due à la présence de dislocations. La comparaison avec les mesures est satisfaisante. Enfin on donne quelques résultats de la résolution numérique directe du système fondamental dans le cas de dislocations isolées. Ceci permet de prévoir la structure des images de dislocations obtenues par transmission. Ici encore on note un accord satisfaisant avec les expériences faites par plusieurs autres auteurs.
Two-Component Waterborne Epoxy Coatings (1997)

The chemistry and properties of two component, waterborne epoxy coatings are reviewed. The coatings are classified by the type of epoxy resin employed. Type I utilize low molecular weight, liquid epoxy resin, and type II use pre-formed dispersions of higher molecular weight, solid epoxy resins. The physical and coatings chemistry of waterborne epoxy coatings is discussed, with particular emphasis on the film formation process. After a description of the general structure-property requirements for the coatings components and the surfactant properties of amine hardeners, a detailed description of the chemistry of the binders for both type I and type II systems is provided, based mostly on the patent literature. General principles of coatings formulation are then provided.
Dobutamine for Inotropic Support during Emergence from Cardiopulmonary Bypass (1976)

Dobutamine, a recently introduced derivative of dopamine, is reported to retain inotropic properties with less pronounced chronotropic and arrhythmogenic effects than isoproterenol. The drug was evaluated in two doses, 5 mug/kg/min and 10 mug/kg/min, in two groups of ten patients each, during emergence from cardiopulmonary bypass. A third group of five patients was studied similarly with isoproterenol, 0.02 mug/kg/min. Cardiac index increased 16 and 28 per cent eith the two doses of dobutamine, respectively, and 9 per cent with isoproterenol. Heart rate, in contrast, increased 6 and 15 per cent with dobutamine (not significant) and 44 per cent with isoproterenol (significant). Dobutamine seemed to associated with fewer arrhythmias than isoproterenol. It is concluded that dobutamine, 5-10 mug/kg/min, is suitable for use during emergence from cardiopulmonary bypass and may possess advantages over isoproterenol.
A Wideband ΔΣ Digital-RF Modulator for High Data Rate Transmitters (2007)

A wideband software-defined digital-RF modulator targeting Gb/s data rates is presented. The modulator consists of a 2.625-GS/s digital DeltaSigma modulator, a 5.25-GHz direct digital-RF converter, and a fourth-order auto-tuned passive LC RF bandpass filter. The architecture removes high dynamic range analog circuits from the baseband signal path, replacing them with high-speed digital circuits to take advantage of digital CMOS scaling. The integration of the digital-RF converter with an RF bandpass reconstruction filter eliminates spurious signals and noise associated with direct digital-RF conversion. An efficient passgate adder circuit lowers the power consumption of the high-speed digital processing and a quadrature digital-IF approach is employed to reduce LO feedthrough and image spurs. The digital-RF modulator is software programmable to support variable bandwidths, adaptive modulation schemes, and multi-channel operation within a frequency band. A prototype IC built in 0.13-mum CMOS demonstrates a data rate of 1.2 Gb/s using OFDM modulation in a bandwidth of 200 MHz centered at 5.25 GHz. In-band LO and image spurs are less than -59 dBc without requiring calibration. The modulator consumes 187 mW and occupies a die area of 0.72 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .