gebhart/patrepeval huggingface dataset:
Kinetic studies of the reduction of ferricytochrome c by ethylenediaminetetraacetatoiron(II) (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic studies of the reduction of ferricytochrome c by ethylenediaminetetraacetatoiron(II)H. Leslie Hodges, R. A. Holwerda, and Harry B. GrayCite this: J. Am. Chem. Soc. 1974, 96, 10, 3132–3137Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://pubs.acs.org/doi/10.1021/ja00817a019https://doi.org/10.1021/ja00817a019research-articleACS PublicationsRequest reuse permissionsArticle Views165Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
System identification and machine setup of color xerographic machines using multivariate modeling and multiobjective optimization (2002)

This paper describes an approach for performing system identification of the xerographic process and developing a model of the overall system. The experiment design is performed using orthogonal arrays. A nonlinear system model defining a vector mapping between the actuators and performance metrics is constructed using multivariate adaptive regression splines. These models provide a basis for providing automated and optimal machine setup on color machines. Multiobjective optimization techniques based on an underlying adaptive simulated annealing approach are discussed, which are then used for determining the Pareto-optimal set-points. The overall approach is applied to perform the automated setups of a high-end color machine-the Docucolor 40. Experimental results show that high quality machine setups can be performed in an efficient and automated manner. The use of these set-points as the basis of linearization about a nominal set-point for use in linear control algorithms are also discussed.
Pentitol metabolism of Rhodobacter sphaeroides Si4: purification and characterization of a ribitol dehydrogenase (1992)

The phototrophic bacterium Rhodobacter sphaeroides strain Si4 induced ribitol dehydrogenase (EC 1.1.1.56) when grown on ribitol- or xylitol-containing medium. This ribitol dehydrogenase was purified to apparent homogeneity by ammonium sulphate precipitation, affinity chromatography on Procion red, and chromatography on Q-Sepharose. For the native enzyme an isoelectric point of pH 6.1 and an apparent M(r) of 50,000 was determined. SDS-PAGE yielded a single peptide band of M(r) 25,000 suggesting a dimeric enzyme structure. The ribitol dehydrogenase was specific for NAD+ but unspecific as to its polyol substrate. In order of decreasing activity ribitol, xylitol, erythritol, D-glucitol and D-arabitol were oxidized. The pH optimum of substrate oxidation was 10, and that of substrate reduction was 6.5. The equilibrium constant of the interconversion of ribitol to D-ribulose was determined to be 0.33 nM at pH 7.0 and 25 degrees C. The Km-values determined for ribitol, ribulose, xylitol and NAD+ (in the presence of ribitol) were 6.3, 12.5, 77 and 0.077 mM, respectively. Because of the favourable Km for ribitol, a method for quantitative ribitol determination was elaborated.
A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters<i>in vivo</i> (2005)

Metabotropic glutamate receptor (mGluR) subtypes (mGluR1 to mGluR8) act as important pre- and postsynaptic regulators of neurotransmission in the CNS. These receptors consist of two domains, an extracellular region containing the orthosteric agonist site and a transmembrane heptahelical domain involved in G protein activation and recognition of several recently synthesized pharmacological modulators. The presynaptic receptor mGluR7 shows the highest evolutionary conservation within the family, but no selective pharmacological tool was known. Here we characterize an mGluR7-selective agonist, N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride (AMN082), which directly activates receptor signaling via an allosteric site in the transmembrane domain. At transfected mammalian cells expressing mGluR7, AMN082 potently inhibits cAMP accumulation and stimulates GTPgammaS binding (EC50-values, 64-290 nM) with agonist efficacies comparable with those of L-2-amino-4-phosphonobutyrate (L-AP4) and superior to those of L-glutamate. AMN082 (< or = 10 microM) failed to show appreciable activating or inhibitory effects at other mGluR subtypes and selected ionotropic GluRs. Chimeric receptor studies position the binding site of AMN082 in the transmembrane region of mGluR7, and we demonstrate that this allosteric agonist has little, if any, effect on the potency of orthosteric ligands. Here we provide evidence for full agonist activity mediated by the heptahelical domain of family 3 G protein-coupled receptors (which have mGluR-like structure) that may lead to drug development opportunities. Further, AMN082 is orally active, penetrates the blood-brain barrier, and elevates the plasma stress hormones corticosterone and corticotropin in an mGluR7-dependent fashion. Therefore, AMN082 is a valuable tool for unraveling the role of mGluR7 in stress-related CNS disorders.
Insulin Attenuates the Systemic Inflammatory Response to Thermal Trauma (2002)

Our data provide insight that insulin attenuates the inflammatory response by decreasing the pro- inflammatory and increasing the anti-inflammatory cas-cade, thereby restoring systemic homeostasis, which has been shown critical for organ function and survival in critically ill patients.
Efficient Approximation of Kalman Filter for Target Tracking (1986)

A Kalman filter in the Cartesian coordinates is described for a maneuvering target when the radar sensor measures range, bearing, and elevation angles in the polar coordinates at high data rates. An approximate gain computation algorithm is developed to determine the filter gains for on-line microprocessor implementation. In this approach, gains are computed for three uncoupled filters and multiplied by a Jacobian transformation determined from the measured target position and orientation. The algorithm is compared with the extended Kalman filter for a typical target trajectory in a naval gun fire control system. The filter gains and the tracking errors for the proposed algorithm are nearly identical to the extended Kalman filter, while the computation requirements are reduced by a factor of four.
Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells. (1994)

Signal transduction initiated by transforming growth factor beta 1 (TGF beta 1) was studied in two sublines of the same colon carcinoma cell line, which respond in opposite ways to TGF beta 1, by proliferation or by growth inhibition. TGF beta 1 activates ras proteins within 5 min of addition when it acts to inhibit growth but not when it acts as a mitogen. In both cases TGF beta 1 also rapidly modulates the activities of three protein kinases, detected by their in gel kinase activity on the mitogen-activated protein kinase (MAP kinase) substrate, myelin basic protein (MBP). When TGF beta 1 acts as a mitogen for U9 cells, it increases the activity of MBP kinases of 57, 105, and 130 kDa within 10 min of the addition without detectably activating ras proteins. When TGF beta 1 inhibits the growth of HD3 cells, it activates ras proteins and the 57-kDa MBP kinase within 5 min but inhibits the activity of the 105- and 130-kDa MBP kinases. In HD3 cells ras activation occurred in two signal transduction pathways, one from TGF beta 1 leading to growth inhibition and one from epidermal growth factor (EGF) leading to proliferation. In addition to ras proteins, EGF activates a different set of MBP kinases in HD3 cells than does TGF beta 1, MBP kinases of 85, 57, and 44 kDa. The latter is likely to be the 44-kDa MAP kinase extracellular signal-regulated kinase (erk) 1, because EGF treatment of HD3 cells activates erk1 by increasing its phosphotyrosine level. Therefore, in two closely related epithelial cell lines TGF beta 1 activates two different signal transduction pathways, one ras-dependent and one ras-independent, and modulates the activities of a set of MBP kinases.
La decisión. Barrio: Anatomía urbana (1999)

De como una pelicula localista rodada en cinco distritos de Madrid se convierte en la historia de cualquier ciudad europea.
Opportunities of Bacterial Cellulose to Treat Epithelial Tissues (2018)

In this mini-review, we highlight the potential of the biopolymer bacterial cellulose to treat damaged epithelial tissues. Epithelial tissues are cell sheets that delimitate both the external body surfaces and the internal cavities and organs. Epithelia serve as physical protection to underlying organs, regulate the diffusion of molecules and ions, secrete substances and filtrate body fluids, among other vital functions. Because of their continuous exposure to environmental stressors, damage to epithelial tissues is highly prevalent. Here, we first compare the properties of bacterial cellulose to the current gold standard, collagen, and then we examine the use of bacterial cellulose patches to heal specific epithelial tissues; the outer skin, the ocular surface, the oral mucosa and other epithelial surfaces. Special emphasis is made on the dermis since, to date, this is the most widespread medical use of bacterial cellulose. It is important to note that some epithelial tissues represent only the outermost layer of more complex structures such as the skin or the cornea. In these situations, depending on the penetration of the lesion, bacterial cellulose might also be involved in the regeneration of, for instance, inner connective tissue.
Case recognition and strategy classification (1993)

In a conventional expert system shell, the process of automated reasoning is generally determined by four components: the current fact situation, a goal, the content of the knowledge base, and control knowledge. This paper focuses on control knowledge. The approach taken is to obtain control knowledge from precedents which resemble the current fact situation. Control knowledge, which is here understood as both referring to search and strategy, is important because control knowledge: 1.-facilitates efficient problem solving; 1.-enables context sensitive and adequate questioning; and 3.-may actually determine the outcome of the reasoning process. With regard to the latter, we believe that one of the manifestations of the discretion a judge is provided with, is that judges often choose a particular control strategy in order to obtain a certain result. As a consequence the strategy followed is often very case-specific. If the aim of a LKBS is to simulate or predict the outcome in a particular problem situation, the system has to simulate or predict the control strategy in this specific case. The model presented uses precedents similar to the case at hand to obtain the applicable control strategy. Neural networks are used to find similar cases. One of the characteristics of the system presented, is, however, that the inferences made by neural networks are not a part of the final reasoning chain. The model is flexible in various ways. Firstly, the precedents may be applicable to a wider range of cases then the precise precedent represented in the case base. Secondly, since the precedent is a model for the control strategy rather than the solution of the case, the amount of problem solving that has to be one after case recognition may vary. This means that the precedent is a model for the type of problem solving and that the specifics of the current case may still determine the precise outcome. Thirdly, since the control strategy determines which questions the system will ask, the recognition method is able to suggest a similar case with the applicable control strategy in a very early stage of problem solving, i.e. before all information is available.
Music similarity based on sequences of descriptors tonal features applied to audio cover song identification (2007)

As music collections are growing up every day, it becomes necessary to keep them organized. Therefore, one critical block of an 'intelligent' system for doing that should deal with the concept of music similarity. From a computational point of view, this concept has been assessed from many angles, being one of the most important the purely audio content-based similarity systems. Traditionally, they have relied in methods that ignored the temporal evolution of the music audio characteristics. It is the goal of this thesis to provide some insights into the benefits of considering temporal sequences representing the musical content of an audio signal. We do that while focusing to an application that have been increasing his popularity along these last few years, as it provides a direct and objective way for evaluating music similarity cover song identification. A cover song (or simply cover) is a new version (performance, rendition or recording) of a previously recorded song. After making an extensive literature summary on related techniques, methods and systems for music similarity (with a special emphasis on cover detecting systems), and presenting our evaluation methodology, we perform several experiments on cover song identification based on state-of-the-art methods (cross-correlation and Dynamic Time Warping). We also study the blocks of these methods that can report more benefits to the final performance of the system and we make some interesting improvements on them (such as considering different PCP distances, beat tracking algorithms, key transposition methods), apart from assessing the intrinsic algorithms' parameters. Furthermore, we propose a new method for determining the similarity between tonal sequences and, therefore, to cover songs. This one is based on a novel HPCP similarity measure, and on a newly developed Dynamic Programming local alignment technique. Results confirm that the performance of the proposed system is significantly superior to the other implemented ones. Along the thesis we keep discussing important details found during the experiments done and future directions to take for accomplishing the chosen task.
Quantification of the Three-Dimensional Displacement of Normal Facial Movement (2000)

This study was undertaken to quantify 3-dimensional (3-D) facial movement in normal subjects, and to identify the individual axes in which this movement occurred. Displacement data on 42 subjects were collected and analyzed with the Expert Vision Motion Analysis System. The 3-D displacement was calculated by vectorially subtracting maximum marker movement from previously identified reference marker points. The 3-D range of normal facial movement was quantified, with the greatest displacement occurring during maximum smile. When the individual axes were examined, we found that most movement occurred in the vertical axes for the majority of expressions, followed by the anterior-posterior axis. These results may create an objective baseline from which disorders of the facial nerve, and hence, medical, surgical, and physiotherapy treatment interventions, can be analyzed in the future.
A Genomic Comparison of <i>in vivo</i> and <i>in vitro</i> Brain Microvascular Endothelial Cells (2007)

The blood-brain barrier (BBB) is composed of uniquely differentiated brain microvascular endothelial cells (BMEC). Often, it is of interest to replicate these attributes in the form of an in vitro model, and such models are widely used in the research community. However, the BMEC used to create in vitro BBB models de-differentiate in culture and lose many specialized characteristics. These changes are poorly understood at a molecular level, and little is known regarding the consequences of removing BMEC from their local in vivo microenvironment. To address these issues, suppression subtractive hybridization (SSH) was used to identify 25 gene transcripts that were differentially expressed between in vivo and in vitro BMEC. Genes affected included those involved in angiogenesis, transport and neurogenesis, and real-time quantitative polymerase chain reaction (qPCR) verified transcripts were primarily and significantly downregulated. Since this quantitative gene panel represented those BMEC characteristics lost upon culture, we used it to assess how culture manipulation, specifically BMEC purification and barrier induction by hydrocortisone, influenced the quality of in vitro models. Puromycin purification of BMEC elicited minimal differences compared with untreated BMEC, as assessed by qPCR. In contrast, qPCR-based gene panel analysis after induction with hydrocortisone indicated a modest shift of 10 of the 23 genes toward a more 'in vivo-like' gene expression profile, which correlated with improved barrier phenotype. Genomic analysis of BMEC de-differentiation in culture has thus yielded a functionally diverse set of genes useful for comparing the in vitro and in vivo BBB.
Statistical sense disambiguation with relatively small corpora using dictionary definitions (1995)

Corpus-based sense disambiguation methods, like most other statistical NLP approaches, suffer from the problem of data sparseness. In this paper, we describe an approach which overcomes this problem using dictionary definitions. Using the definition-based conceptual co-occurrence data collected from the relatively small Brown corpus, our sense disambiguation system achieves an average accuracy comparable to human performance given the same contextual information.
Radiation performance of the ERS-1 SAR EM antenna (2003)

The engineering model (EM) of the synthetic aperture radar (SAR) antenna for the European remote sensing satellite ERS-1 has been electrically tested on a dedicated planar near-field test facility. An outline description of both antenna and test facility is given. Radiation characteristics of the antenna are presented that show good electrical performances for the model antenna.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Status of standards for teleconferencing and multimedia communication (2002)

Video teleconferencing (VTC) is being successfully employed throughout the Department of Defense (DoD), in both strategic and tactical environments. It is also being deployed in a wide range of communication network infrastructures: mobile, circuit switched, ISDN, ATM, LAN, Internet, DCTN, and FTS2000. Fortunately commercial VTC standards are being employed in most of these applications thereby contributing to interoperability between these diverse terminals and networks. This paper reviews the status of VTC standards and some of the key applications throughout the DoD. Standards which are reviewed include H.320 (N-ISDN), H.323 (LAN and Internet), H.324 (POTS), H.324M (mobile), H.310 (B-ISDN), and T.120 (desktop collaboration).
Interactive Role of Trauma Cytokines and Erythropoietin and Their Therapeutic Potential for Acute and Chronic Wounds (2011)

If controllable, stem cell activation following injury has the therapeutic potential for supporting regeneration in acute or chronic wounds. Human dermally-derived stem cells (FmSCs) were exposed to the cytokines interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α) in the presence of erythropoietin (EPO). Cells were cultured under ischemic conditions and phenotypically characterized using flow cytometry. Topical EPO application was performed in three independent clinical wound healing attempts. The FmSCs expressed the receptor for EPO. EPO had a strong inhibitory effect on FmSC growth in the absence of IL-6 and TNF-α. With IL-6, the EPO effects were reversed to that of growth stimulation. TNF-α had the strongest stimulatory effect. In contrast, IL-1β had an inhibitory effect. Topically applied EPO considerably enhanced wound healing and improved wound conditions of acute and chronic wounds. Site specificity of stem cell activation is mediated by IL-6 and TNF-α. In trauma, EPO ceases its inhibitory role and reverts to a clinically relevant boosting function. EPO may be an important therapeutic tool for the topical treatment of acute and chronic wounds.
Lack of Effect of Different Cytokines on Expression of Membrane-Bound Regulators of Complement Activity on Human Uveal Melanoma Cells (1997)

Tumor cells are protected from antibody-dependent complement-mediated lysis by membrane-bound regulators of complement activation (m-RCA). m-RCA are expressed on uveal melanoma cells. We determined whether cytokine treatment affects expression of m-RCA on these cells in vitro. m-RCA expression on uveal melanoma cell lines was studied by flow cytometry, using monoclonal antibodies directed against CD46, CD55, and CD59. Cytokines studied were interferon-alpha (IFN-alpha), IFN-gamma, interleukin-1B (IL-1B), IL-12, and tumor necrosis factor-alpha (TNF-alpha). All three m-RCA were expressed on the uveal melanoma cell lines (CD59>>CD46>CD55), although in variable amounts. With a few exceptions, the cytokines had no effect on m-RCA expression. CD55 expression was not influenced by any of the cytokines. IFN-gamma downregulated expression of CD46 on one cell line (p < 0.01). TNF-alpha upregulated CD59 expression on two of the five cell lines (p < 0.012 and p < 0.001, respectively), which effect was dose dependent. IFN-alpha, IFN-gamma, IL1-beta, IL12, and TNF-alpha had limited effects on m-RCA expression on uveal melanoma cells in vitro.
Strut Coverage and Late Malapposition With Paclitaxel-Eluting Stents Compared With Bare Metal Stents in Acute Myocardial Infarction (2011)

URL: http://www.clinicaltrials.gov. Unique identifier: NCT00433966.
Utility of Thromboelastography in Managing Acquired Factor VIII Inhibitor Associated Massive Haemorrhage (2013)

Disorders of clotting and coagulation are common in the intensive care unit. Diagnosis, treatment and monitoring of these disorders are traditionally based on conventional coagulation tests such as activated partial thromboplastin time (APTT) and international normalised ratio (INR). We present here a patient who developed massive postoperative haemorrhage secondary to an acquired factor VIII inhibitor. The case highlights the utility and sensitivity of thromboelastography (TEG) in the diagnosis of the condition and monitoring the response to therapy.