gebhart/patrepeval huggingface dataset:
Electron ionization mass spectrometry of curcumin analogues: an olefin metathesis reaction in the fragmentation of radical cations (1998)

The natural compound curcumin, used in cosmetics, traditional medicines and as a spice in food, is known as a multi-factorial anti-inflammatory agent. To study the anti-inflammatory activity of curcumin derivatives, 24 analogues were synthesized and their structures were confirmed by 1H NMR and electron ionization (EI) mass spectrometry. Most signals in the EI mass spectra can be attributed to commonly known fragmentations, but the formation of ring-substituted 1,2-diphenylethene (stilbene)-type radical cations, observed in the spectra of all compounds investigated and resulting in the base peak for some compounds, requires a peculiar rearrangement. Metastable ion spectra and 13C labelling studies show that the stilbene-type ions are formed directly from the molecular ions and contain the two original aryl groups and the 1 and 7 carbon atoms of the olefinic system. It is proposed that the formation of stilbene-type ions results from an intramolecular olefin metathesis reaction; this suggestion is supported by semi-empirical (MNDO/PM3) calculations. © 1998 John Wiley & Sons, Ltd.
Realistic Dynamic Facial Textures from a Single Image Using GANs (2017)

We present a novel method to realistically puppeteer and animate a face from a single RGB image using a source video sequence. We begin by fitting a multilinear PCA model to obtain the 3D geometry and a single texture of the target face. In order for the animation to be realistic, however, we need dynamic per-frame textures that capture subtle wrinkles and deformations corresponding to the animated facial expressions. This problem is highly underconstrained, as dynamic textures cannot be obtained directly from a single image. Furthermore, if the target face has a closed mouth, it is not possible to obtain actual images of the mouth interior. To address this issue, we train a Deep Generative Network that can infer realistic per-frame texture deformations, including the mouth interior, of the target identity using the per-frame source textures and the single target texture. By retargeting the PCA expression geometry from the source, as well as using the newly inferred texture, we can both animate the face and perform video face replacement on the source video using the target appearance.
Anaphylaxis: risk factors for recurrence (2003)

In any 1 year, 1/12 patients who have suffered anaphylaxis will experience recurrence, and 1/50 will require hospital treatment or use adrenaline. Compliance with carrying and using adrenaline is poor. Occasional patients develop new triggers or suffer psychiatric morbidity.
[Normal imaging of facial sinuses]. (1991)

The high spatial resolution of computed tomography allows visualisation of the fine structures of the facial skeleton and gives precise information about the anatomy of the nasal cavity, the paranasal sinuses and their relations with adjacent structures. A detailed knowledge of the normal anatomy, particularly of the nasal cavity and ethmoid, is very useful to provide to the surgeon with a precise pre operative surgical map, before transnasal endoscopic ethmoidectomy or management of paranasal sinuses tumors.
Identification of a Two-Partner Secretion Locus of Enterotoxigenic <i>Escherichia coli</i> (2006)

Enterotoxigenic Escherichia coli (ETEC) remains a formidable cause of diarrheal illness worldwide. At present, there is no vaccine that provides broad-based protection against ETEC. A 'phoA-based self-cloning mutagenesis system, TnphoA.ts, employed to identify novel ETEC surface antigens, led to identification of an ETEC two-partner secretion locus (etpBAC) on the pCS1 virulence plasmid of prototype strain H10407. Cloning and expression of etpBAC in recombinant E. coli LMG194(pJY019) resulted in secretion of a high-molecular-weight (HMW) glycosylated exoprotein. This glycoprotein, EtpA, exhibits linear peptide sequence and predicted structural homologies with known HMW adhesins produced by other two-partner secretion loci. Antibodies directed against recombinant EtpA (anti-rEtpA.6H) recognized an HMW protein in culture supernatants of ETEC strains H10407 and LMG194(pJY019) but not in culture supernatant of strain H10407-P, which lacks the 92-kb pCS1 plasmid, or an isogenic etpA mutant. etpA mutants were deficient in adherence to intestinal epithelial cells in vitro, and anti-rEtpA.6H antibodies inhibited association of H10407 with target epithelial cells. Cloning and expression of etpB in recombinant E. coli were sufficient to confer adherence. Screening of multiple ETEC isolates for the etpBAC locus by colony hybridization and by EtpA immunoblotting suggested that EtpA is one of the most common antigens secreted by these pathogens. Together, these results indicate that the newly identified ETEC two-partner secretion locus directs the secretion of a high-molecular-weight glycosylated protein, EtpA, that in concert with the putative EtpB transporter participates in adherence of H10407 to epithelial cells, thereby expanding the repertoire of potential ETEC virulence proteins and vaccine candidates.
Survival of baboon biotin‐X‐N‐hydroxysuccinimide and <sup>111</sup>In‐oxine‐labelled autologous fresh and lyophilized reconstituted platelets (2005)

Lyophilized reconstituted baboon platelets labelled with (111)In-oxine or biotin-X-NHS before autotransfusion exhibited an in vivo circulation time of less than 15 min. Further study of the lyophilized, reconstituted platelets is required to evaluate their haemostatic function.
R2Fix: Automatically Generating Bug Fixes from Bug Reports (2013)

Many bugs, even those that are known and documented in bug reports, remain in mature software for a long time due to the lack of the development resources to fix them. We propose a general approach, R2Fix, to automatically generate bug-fixing patches from free-form bug reports. R2Fix combines past fix patterns, machine learning techniques, and semantic patch generation techniques to fix bugs automatically. We evaluate R2Fix on three projects, i.e., the Linux kernel, Mozilla, and Apache, for three important types of bugs: buffer overflows, null pointer bugs, and memory leaks. R2Fix generates 57 patches correctly, 5 of which are new patches for bugs that have not been fixed by developers yet. We reported all 5 new patches to the developers; 4 have already been accepted and committed to the code repositories. The 57 correct patches generated by R2Fix could have shortened and saved up to an average of 63 days of bug diagnosis and patch generation time.
Publisher Correction: Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly (2019)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Some Television Problems from the Motion Picture Standpoint<!--<xref ref-type="other" rid="fn1-10.5594_J14638">*</xref>--> (1939)

Certain of the characteristics of television have their counterparts in motion pictures, and motion picture film and motion picture practice are applicable to television. Some of the problems and limitations pertaining thereto are outlined, and the following television-image characteristics are briefly discussed: (1) Number of scanning lines and the relationship to image size and viewing distance; (2) number of frames; (3) interlacing. — The effect of film and optical system limitations on reproduced television images is illustrated by photographs, and curves are given showing the spectral characteristics of Iconoscopes. The screen color characteristics of Kinescopes are also discussed, and the overall range and gamma characteristics of a television system are reviewed.
The PtdIns 3-Kinase/Akt Pathway Regulates Macrophage-Mediated ADCC against B Cell Lymphoma (2009)

Macrophages are important effectors in the clearance of antibody-coated tumor cells. However, the signaling pathways that regulate macrophage-induced ADCC are poorly defined. To understand the regulation of macrophage-mediated ADCC, we used human B cell lymphoma coated with Rituximab as the tumor target and murine macrophages primed with IFNgamma as the effectors. Our data demonstrate that the PtdIns 3-kinase/Akt pathway is activated during macrophage-induced ADCC and that the inhibition of PtdIns 3-kinase results in the inhibition of macrophage-mediated cytotoxicity. Interestingly, downstream of PtdIns 3-kinase, expression of constitutively active Akt (Myr-Akt) in macrophages significantly enhanced their ability to mediate ADCC. Further analysis revealed that in this model, macrophage-mediated ADCC is dependent upon the release of nitric oxide (NO). However, the PtdIns 3-kinase/Akt pathway does not appear to regulate NO production. An examination of the role of the PtdIns 3-kinase/Akt pathway in regulating conjugate formation indicated that macrophages treated with an inhibitor of PtdIns 3-kinase fail to polarize the cytoskeleton at the synapse and show a significant reduction in the number of conjugates formed with tumor targets. Further, inhibition of PtdIns 3-kinase also reduced macrophage spreading on Rituximab-coated surfaces. On the other hand, Myr-Akt expressing macrophages displayed a significantly greater ability to form conjugates with tumor cells. Taken together, these findings illustrate that the PtdIns 3-kinase/Akt pathway plays a critical role in macrophage ADCC through its influence on conjugate formation between macrophages and antibody-coated tumor cells.
Investigating the Role of Respiration in Plant Salinity Tolerance by Analyzing Mitochondrial Proteomes from Wheat and a Salinity-Tolerant Amphiploid (Wheat × <i>Lophopyrum elongatum</i>) (2013)

The effect of salinity on mitochondrial properties was investigated by comparing the reference wheat variety Chinese Spring (CS) to a salt-tolerant amphiploid (AMP). The octoploid AMP genotype was previously generated by combining hexaploid bread wheat (CS) with the diploid wild wheatgrass adapted to salt marshes, Lophopyrum elongatum. Here we used a combination of physiological, biochemical, and proteomic analyses to explore the mitochondrial and respiratory response to salinity in these two genotypes. The AMP showed greater growth tolerance to salinity treatments and altered respiration rate in both roots and shoots. A proteomic workflow of 2D-DIGE and MALDI TOF/TOF mass spectrometry was used to compare the protein composition of isolated mitochondrial samples from roots and shoots of both genotypes, following control or salt treatment. A large set of mitochondrial proteins were identified as responsive to salinity in both genotypes, notably enzymes involved in detoxification of reactive oxygen species. Genotypic differences in mitochondrial composition were also identified, with AMP exhibiting a higher abundance of manganese superoxide dismutase, serine hydroxymethyltransferase, aconitase, malate dehydrogenase, and β-cyanoalanine synthase compared to CS. We present peptide fragmentation spectra derived from some of these AMP-specific protein spots, which could serve as biomarkers to track superior protein variants.
Comparison of two LAN bridge approaches (1988)

The authors review the differences between two media access control (MAC) bridge algorithms for local area networks (LANs) currently being specified by the IEEE 802 Standards Committee. They are the IEEE 802.5 Source Routing Scheme and the IEEE 802.1 Transparent Spanning Tree Scheme. A brief summary of the two schemes, along with the relevant technical points that cause differences in features or performance, is included. It is concluded that transparent spanning tree architecture appears to offer the best solution for bridging local area networks with regard to such factors as robustness, efficiency, stability, determinism, and simplicity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Production of fine particles by Autogenous Grinding with a Stirred Mill. (1991)

In order to study the influence of feed particle size on energy efficiency for production of fine particles, autogenous grinding tests were carried out using a stirred mill. The mill used was made of stainless steel and its volume was about 5.5 liters. The impellers were always run at a rotational speed of 69 rev/min. The sample used was limestone. The material was charged 5 kg and the feed size were 2.0-1.3, 1.3-1.O and1.0-0.67cm, respectively. The ground products were sieved in the size range from the feed size to 3μm.As a result, it was found that the energy consumption to produce the particles finer than 3μm decreased with increase in the feed size and it became minimum when the feed size was closer to the distance between the top edge of the impeller and the wall of mill.
Ozone Delignification of Pine and Eucalyptus Kraft Pulps. 1. Kinetics (1999)

The kinetics of ozone delignification of unbleached pine and eucalyptus kraft pulps is studied at ultralow consistency in a stirred reactor. Ozone consumption was monitored with sensors located in both the liquid and gas phases of the reacting medium, and the results confirm the expectations, i.e., the very high oxidation rates. The experiments were carried out following two different approaches that give rise to very different ozone concentration profiles in the pulp suspension and to significant improvements in the statistical contents of the experimental data. In the development of the delignification model, special attention was paid to its validation and thus different sets of data for training and validation were used, leading to high levels of confidence in the model. As far as the delignification is concerned, its rate can be described for both pulps by a pseudohomogeneous model with partial orders of 1 and 2 for ozone and lignin contents, respectively. However, the remaining parameters of the kinetic model are markedly different for the two pulps. The effect of temperature on the delignification rate is small and can be characterized by an activation energy close to 20 kJ/mol for both pulps.
Economic Impacts of Electric Power Outages and Evaluation of Customer Interruption Costs (2015)

Electricity has become a vital part of the modern societies. Thanks to using electrical equipment in almost every aspect of the life, in case of an interruption the daily routine is paralyzed. Whether the electricity is a social right or not is still debatable. No matter it is a social right or commodity, improving the electric power reliability so that more people (or customers) will have the opportunity to make use of this service is in favor of everyone in the market.\nEurope has been known to have robust, well developed and well planned electric power systems. This meant considerably high level of reliability for the European societies until the beginning of 2000's. Nevertheless, during the last decade there has been an increase in the number of extreme weather related disasters throughout the world. Natural disasters have become the primary threats for the continuity of electricity service in Europe and in the rest of the world.\nStudying customer interruption costs and proposing credible and practical estimation methods is a challenging task. The necessity of this research arose from the lack of widely accepted and easy to adopt approaches in the field. Each customer segment has its own distinct electric power consumption and dependence characteristics. This fact indicates the necessity of analyzing each customer group separately and proposing unique customer interruption costs estimation techniques. Having a developed power system and easiness to reach credible data for analysis, Finland is a proper country to study the economic impacts of the electric power interruptions. The ultimate goal of this research is to provide outage cost estimations which will be; customer specific, utilizing publicly declared and objective data, demanding less time, less money and less effort, easy to duplicate in any part of the world and providing credible and sound results.\nIn order to achieve these goals, in this research, the customers are divided into three main segments; industry customers, service customers and residential customers. Different and unique customer interruption costs estimation methodology has been proposed for each customer segment.
Dioxygen Activation and Substrate Oxygenation by a <i>p</i>-Nitrothiophenolatonickel Complex: Unique Effects of an Acetonitrile Solvent and the <i>p</i>-Nitro Group of the Ligand (2011)

The nickel(II) complex [Ni(Tp(Me2)) (SC(6)H(4)NO(2))] [1a; Tp(Me2) = hydrotris(3,5-dimethylpyrazol-1-yl)borate] reacts with O(2) to form the ligand oxygenation product ArSO(2)(-) in MeCN, and also 1a catalyzes the oxygenation of external substrates such as triphenylphosphine. The reactivity may correlate to the unique quinoid-like resonance structure of the thiophenolate ligand. The structure is stabilized by a p-nitro group and induced by coordination of MeCN.
Thromboxane A2 mediates cisplatin‐induced apoptosis of renal tubule cells (1997)

The purpose of this study was to elucidate the role of thromboxane A2 (TXA2) in cisplatin-induced apoptosis of mouse renal cells derived from the terminal proximal tubule (S3). RT-PCR analysis revealed that S3 cells express TXA2 receptor mRNA. A TXA2 receptor antagonist, KW-3635, dose-dependently inhibited cisplatin-induced apoptosis of S3 cells. Treatment of S3 cells with a TXA2 agonist, STA2, induced a significant decrease in their viability and resulted in the characteristic ladder pattern resulting from intranucleosomal DNA cleavage. Treatment with KW-3635 resulted in attenuation of the increase in c-fos mRNA expression level in cisplatin-treated S3 cells. In conclusion, TXA2 appears to mediate cisplatin-induced apoptosis of S3 cells by inducing an increase in the level of c-fos mRNA expression.
An Evaluation of Laryngeal Muscle Activation in Patients with Voice Tremor (1992)

Eight patients with voice tremor were studied to characterize laryngeal muscle involvement. Electromyographic (EMG) recordings were made from intrinsic laryngeal muscles, simultaneously with some extrinsic laryngeal muscles, respiratory movement, and voice recordings during respiration, whisper, and phonation. Spectral measures were used to determine the tremor frequency and the prominence of spectral peaks in the EMG, respiratory and acoustic signals, while correlation coefficients were computed between pairs of tremulous EMG signals to measure the synchrony of tremor between muscles. The intrinsic laryngeal muscles were tremulous during respiration and speech, with the thyroarytenoid most often involved. Tremor was also detected in some of the extrinsic muscle recordings and the percentage of muscles with tremor was higher during phonation than during whisper or respiration. Time delays were found between tremor oscillations in laryngeal muscles. Because the thyroarytenoid was affected in all the patients studied, botulinum toxin injections may be beneficial in treatment of this voice disorder.
Dark Fermentative Hydrogen Production from Xylose in Different Bioreactors Using Sewage Sludge Microflora (2007)

In this study, the H2-producing activity of the sewage sludge microflora using xylose as the sole carbon substrate was investigated in three bioreactor systems, including a suspended continuously stirred tank reactor (CSTR), an immobilized-cell continuously stirred anaerobic bioreactor (IC-CSABR), and a powder activated carbon-assisted agitated granular sludge bed (AGSB). For suspended-culture CSTR operations, fermentative H2 production was conducted at different hydraulic retention times (HRT = 4–12 h). The H2 production rate (HPR) was 183 mmol/L/d at HRT = 12 h, but the H2 production rate and yield decreased significantly when the HRT was shortened to 4 h due primarily to the washout of cells. To improve the operational stability of short HRTs, silicone-immobilized cells (IC-CSABR system) and powder activated carbon carriers (AGSB system) were adopted for the reactor systems to either maintain stable biomass concentration in the reactor or enhance biomass content by stimulating sludge granulation. Both IC-CSABR and AGSB showed improved biomass retention while operating at a HRT of 4 h. In particular, the biomass content in the IC-CSABR system (HRT = 2 h) went up to 8.03 g of VSS/L, leading to a drastic enhancement in the H2 production rate (1.06 mol/L/d). Bacterial community analysis by denatured gradient gel electrophoresis (DGGE) indicates a transition in bacterial composition in the CSTR under different HRT conditions. Moreover, under the same HRT (4 h), the major bacterial populations in the AGSB and IC-CSABR reactors were very different from those observed in the CSTR, indicating that the performance of H2 production seemed to be in close connection with the bacterial community structure. Several H2-producing bacterial strains (e.g., Clostridium butyricum and Klebsiella pneumoniae) were also detected in the sludge samples by DGGE and 16S rDNA sequence matching, revealing the effectiveness of the H2-producing sludge used in this study.
Genetic parameters and breed differences for feed efficiency, growth, and body composition traits of young beef bulls (2004)

Genetic associations between feed efficiency, growth, and live ultrasound measured body composition traits were studied in purebred beef bulls of six breeds in Ontario bull test stations from 1991 to 2000. Feed traits included average daily feed intake (FI), feed conversion ratio (FCR), and residual feed intake [feed intake adjusted for production alone (RFIp) or production and backfat thickness (RFIb)]. Growth traits were average daily weight gain (ADG), mid-test metabolic weight (MW), hip height (HH), and scrotal circumference (SC). Body composition traits included ultrasound backfat thickness (BF), longissimus muscle area (LMA), and predicted percentage of intramuscular fat (IFAT). Bulls were measured every 28 d for weight and individual feed intake, and at the end of test for ultrasound body composition traits. Number of records per trait ranged from 2284 (FI) to 13 319 (ADG). Fixed effects of test group, breed and end of test age (within breed), and random effects of animal and herd of origin were modeled using REML bivariate analyses for all traits. Heritability estimates were moderate for all traits (0.30 to 0.55), except for IFAT (0.14). The genetic correlation between RFIp and RFIb was high (0.99) within breeds, but breeds ranked differently with respect to RFIp and RFIb. Genetic correlations of RFIb with ADG and backfat thickness were essentially zero, which indicate that selection on residual feed intake could be implemented to reduce feed intake and improve feed conversion without compromising growth or changing levels of subcutaneous fat. Key words: Central test, genetic correlation, heritability, residual feed intake