gebhart/patrepeval huggingface dataset:
Sustained‐release (+)‐PHNO [MK‐458 (HPMC)] in the treatment of Parkinson's disease: Evidence for tolerance to a selective D<sub>2</sub>‐receptor agonist administered as a long‐acting formulation (1990)

4-Propyl-9-hydroxynaphthoxazine, or MK-458 (HPMC), a selective, nonergot D2 agonist administered orally twice a day in sustained-release form, was studied as adjunctive therapy with carbidopa-levodopa (Sinemet) in 12 Parkinson's disease patients with motor response fluctuations. The dosage of agonist was gradually increased over 12 weeks to a maximum tolerated level of up to 60 mg/day, and that of Sinemet was reduced concurrently. After 8 weeks, reduction of Sinemet averaged 45.1%, but over the next 4 weeks, despite a continued increase in dosage of the agonist, patients were unable to decrease their Sinemet further, and by 12 weeks mean reduction in Sinemet was only 32%. Only five patients completed the planned 24-week study, mostly due to progressive loss of efficacy. The MK-458 is capable of partially substituting for Sinemet in dosages employed in this study. Reduced sensitivity to the drug can appear over a relatively short time, perhaps as a result of down-regulation of postsynaptic dopamine receptors.
Kinetic method for the determination of nanogram amounts of lead(II) using its catalytic effect on the reaction of manganese(II) with 5,10,15,20-tetrakis(4-sulphonatophenyl)porphine (1987)

Lead(II) accelerates the reaction of manganese(II) with 5,10,15,20-tetrakis(4-sulphonatophenyl)porphine (H2tspp). The kinetics and mechanism of this reaction were studied at pH 6–8.7, 25 °C and l= 0.1 (NaNO3). Lead(II) rapidly forms PbII(tspp) as a reaction intermediate; PbII(tspp) is 7200 times as reactive as the free base porphyrin (H2tspp) in the reaction with manganese(II). Lead(II) concentrations as low as 10–7 mol dm–3 can be determined from the decrease in absorbance at 413 nm (λmax. of H2tspp) at a fixed time after the start of the reaction of manganese(II) with H2tspp. After the separation of lead(II) from iron and silicate by solvent extraction using n-decanoic acid, the proposed method is highly selective and free from interference from most substances usually encountered in the samples studied if carried out in the presence of cyanide as a masking agent for cadmium(II). The molar absorptivity and Sandell's sensitivity calculated from the calibration graph 15 min after the start of the reaction are 2.75 × 105 mol–1 dm3 cm–1 and 0.75 ng cm–1, respectively. The method was applied to the determination lead(II) in rain and drain water.
Active ingredients of the therapeutic relationship that promote client change: A research perspective (2007)

A good relationship between client and therapist is, at the very least, considered to be the base from which all therapeutic work takes place. This
circumscribed view of the therapeutic relationship is often taken by cognitive
and behavioural therapists and is described as ``professional skills'' in the
most widely used instrument for assessing therapist competence in cognitive
and behavioural therapy (CBT) (Cognitive Therapy Scale; Young & Beck,
1988). For other psychotherapy schools, the therapeutic relationship is seen
as one of the main therapeutic tools for achieving client change (Luborsky,
1994; Klerman, Weissman, Rounsville, & Chevron, 1984). Whatever therapeutic processes are involved in the client±therapist relationship, research
has consistently shown a signi®cant association between this relationship
and outcome. For example, Norcross (2002) summarised the literature on
predictors of outcome in psychotherapy and stated that 15% of outcome is
due to expectancy effects, 15% to techniques, 30% to ``common factors''
which primarily involve the therapeutic relationship, and 40% to extratherapeutic change.
Hospitalists taking comprehensive approach to improve care of children with asthma (2012)

The hospitalization of a child with asthma may be considered a sentinel event — a marker of potentially preventable lapses in the child’s care. Unfortunately, this scenario is common as asthma is among the top three reasons for hospitalization in children.

While understanding of the barriers to
Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues (2002)

MS-1, a high-molecular-mass protein expressed by non-continuous and angiogenic endothelial cells and by alternatively activated macrophages (Mphi2), and the hepatic sinusoidal endothelial hyaluronan clearance receptor are similar with respect to tissue distribution and biochemical characteristics. In the present study we purified these proteins by immuno- and hyaluronan-affinity chromatography respectively, sequenced tryptic peptides and generated full-length cDNA sequences in both mouse and human. The novel genes, i.e. stabilin-1 and stabilin-2, code for homologous transmembrane proteins featuring seven fasciclin-like adhesion domains, 18-20 epidermal-growth-factor domains, one X-link domain and three to six B-(X(7))-B hyaluronan-binding motifs. Northern-blotting experiments revealed the presence of both stabilins in organs with predominant endothelial sinuses such as liver, spleen and lymph node: stabilin-1 mRNA was also detected in organs with predominant Mphi2 cells, such as placenta, and in interleukin-4/glucocorticoid-stimulated Mphi2 cells in vitro. A polyclonal antibody made against human recombinant stabilin-1 confirmed the expression of stabilin-1 protein in splenic sinus endothelial cells in vivo and in Mphi2 in vitro. On the basis of high similarity at the protein level and the unique domain composition, which differs from that of all other known fasciclin-like proteins and hyaluronan receptors, stabilin-1 and stabilin-2 define a novel family of fasciclin-like hyaluronan receptor homologues that might play a role in cell-cell and cell-matrix interactions in vascular function and inflammatory processes.
Effect of pretreating samples with boric acid before liquid-chromatographic determination of urinary catecholamines. (1987)

Isolation of catecholamines on prepacked gravity-fed ion-exchange columns in conjunction with liquid-chromatographic separation is occasionally subject to disturbances of unknown origin, especially after injection of H3BO3 eluates from the ion-exchange columns onto the chromatography column. Peak spreading, sometimes even peak splitting, has been observed in many laboratories--effects easily confused with those sometimes caused by voided columns or by impurities. To elucidate the origins of these interferences, we performed a combined voltammetric and chromatographic investigation. We show that complexation of the catechol group by borate ions and dissociation of those pH-labile complexes in the course of the chromatographic separation is the cause of those peak distortions. Addition of a small volume of diluted HCI to the borate eluates eliminates such interference and leads to reproducible, easily interpretable chromatographic separations.
Kettenverlängerung von Kohlenhydraten mit Hilfe von <i>C</i>‐Phenylglycin (1986)

Abstract Durch Ketenverlängerung mit Hilfe von C ‐Phenylglycin lassen sich peracetylierte Glycon‐und Glycuronsäuren mit Polyprenyl‐ und anderen Allylresten verknüpfen. Man erhält die β,γ‐ungesättigten Ketone 3 , die nach Schutzgruppenabspaltung in die Ketosen 4 übergeführt werden können. Die Reaktionssequenz erlaubt damit den formalen Ersatz eines Wasserstoffatoms am anomeren Zentrum einer Hexopyranose durch einen substituierten Allylrest.
Highly modified spontaneous emissions in YVO4:Eu3+ inverse opal and refractive index sensing application (2012)

Here, we present strong modification of photonic crystals on the spontaneous emissions of Eu3+ ions in YVO4:Eu3+ inverse opal. It is interesting that due to the effect of local field, the 5D0-7FJ radiative lifetimes of Eu3+ ions in the PCs are all prolonged ∼2.5 times in contrast to the grinded reference (REF) in air, consistent with the empty cavity model. The photonic stop band and the radiative lifetime are both highly sensitive to the refractive index of the infiltrated solutions, in accordance with the real cavity model.
A Review of the Polymer for Cryogenic Application: Methods, Mechanisms and Perspectives (2021)

Recently, the application of polymer-based composites at cryogenic conditions has become a hot topic, especially in aerospace fields. At cryogenic temperature, the polymer becomes more brittle, and the adverse effect of thermal stress induced by temperature is more remarkable. In this paper, the research development of thermoset and thermoplastic polymers for cryogenic applications are all reviewed. This review considers the literature concerning: (a) the cryogenic performance of modified thermoset polymers and the improving mechanisms of the reported modification methods; (b) the cryogenic application potential of some commercial thermoplastic polymers and the cryogenic performance of modified thermoplastic polymers; (c) the recent advance in the use of polymer for special cryogenic environment-liquid oxygen. This paper provides a comprehensive overview of the research development of the polymer for cryogenic application. Moreover, future research directions have been proposed to facilitate its practical applications in aerospace.
Vision-Based Hand Gesture Recognition Using PCA+Gabor Filters and SVM (2009)

In this paper we present a novel method for hand gesture recognition based on Gabor filters and support vector machine (SVM). Gabor filters are first convolved with images to acquire desirable hand gesture features. The principal components analysis (PCA) method is then used to reduce the dimensionality of the feature space. With the reduced Gabor features, SVM is trained and exploited to perform the hand gesture recognition tasks. To confirm the robustness of the proposed method, a dataset with large posed-angle (>45 deg.) of hand gestures is created. The experiment result shows that the recognition rate of 95.2% can be achieved when SVM is used. A real-time video system for hand gesture recognition is also presented with a processing rate of 0.2 s for every frame. This result proves the efficiency and superiority of the proposed Gabor-SVM method.
Wide-band, time-resolved photoacoustic study of electron-transfer reactions: photoexcited magnesium porphyrin and quinones (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWide-band, time-resolved photoacoustic study of electron-transfer reactions: photoexcited magnesium porphyrin and quinonesJehuda Feitelson and David C. MauzerallCite this: J. Phys. Chem. 1993, 97, 32, 8410–8413Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://doi.org/10.1021/j100134a009RIGHTS & PERMISSIONSArticle Views67Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (476 KB) Get e-Alerts
Catecholamines in diabetic retinopathy. (1983)

An attempt has been made to correlate the catecholamines and diabetic retinopathy. Plasma catecholamines and their urinary metabolite, vanillylmandelic acid, were measured in 53 cases of different stages of diabetic retinopathy and the results compared with the 30 cases of the control group. The study revealed a rise in total plasma catecholamines that was significant in the preretinopathic stage and highly significant in the early as well as in the late stages of diabetic retinopathy. Thus, catecholamines may play an important role in the pathogenesis of diabetic retinopathy by stimulating the counterregulatory hormones, namely growth hormone and glucagon.
Viscoelastic Properties of Isomeric Alkylglucoside Surfactants Studied by Surface Light Scattering (2005)

Surface light scattering (SLS) by capillary waves was used to investigate the adsorption behavior of non-ionic sugar surfactants at the air/liquid interface. SLS by the subphase (water) followed predictions from hydrodynamic theory. The viscoelastic properties (surface elasticity and surface viscosity) of monolayers formed by octyl beta-glucoside, octyl alpha-glucoside, and 2-ethylhexyl alpha-glucoside surfactants were quantified at submicellar concentrations. It is further concluded that a diffusional relaxation model describes the observed trends in high-frequency, nonintrusive laser light scattering experiments. The interfacial diffusion coefficients that resulted from fitting this diffusional relaxation model to surface elasticity values obtained with SLS reflect the molecular dynamics of the subphase near the interface. However, differences from the theoretical predictions indicate the existence of effects not accounted for such as thermal convection, molecular rearrangements, and other relaxation mechanisms within the monolayer. Our results demonstrate important differences in molecular packing at the air-water interface for the studied isomeric surfactants.
Weight similarity measurement model based, object oriented approach for bug databases mining to detect similar and duplicate bugs (2009)

In this paper data mining is applied on bug database to discover the similar and duplicate bugs. Whenever a new bug will be entered in the bug database through bug tracking system, it will be matched against the existing bugs and duplicate and similar bugs will be mined from the bug database. Similar kind of bugs are resolved in almost in same manners. So if a bug is found somewhere similar to other existing bug which is already resolved then its resolution will take less time, since some of the bug analysis part is similar to existing one, hence it will save time. In the existing tradition developers must have to manually identify duplicate bug reports, but this identification process is time-consuming and exacerbates the already high cost of software maintenance. So if the similar and duplicate bugs can be found out using some approach it will be a cost and time saving activity. Based on this concept a weight similarity measurement model based object orinted approach is described here in this paper to discover similar and duplicate bugs in the bug database.
The science behind percutaneous hemodynamic support: A review and comparison of support strategies (2012)

Patients in a variety of cardiovascular disease states may benefit from temporary percutaneous cardiac support, including those in acute decompensated heart failure, fulminant myocarditis, acute myocardial infarction with or without cardiogenic shock and those undergoing high-risk percutaneous coronary intervention. The ideal percutaneous cardiac support device is safe, easy to use and versatile enough to meet the needs of various clinical situations and patient cohorts. In addition, it should provide maximal hemodynamic support and protection against myocardial ischemia. With these goals in mind, the scientific principles that govern hemodynamic effectiveness and myocardial protection as they pertain to acute support devices are reviewed.
Ex Vivo and In Vivo Evaluation of Overexpressed VLA-4 in Multiple Myeloma Using LLP2A Imaging Agents (2016)

(64)Cu-LLP2A and LLP2A-Cy5 demonstrated binding specificity for VLA-4 in an immune-competent murine MM model. (64)Cu-LLP2A displayed favorable dosimetry for human studies and is a potential imaging candidate for overexpressed VLA-4.
Distinct mesenchymal progenitor cell subsets in the adult human synovium (2009)

We report for the first time the co-existence, within the synovium, of progenitor cell subsets with distinct mesenchymal differentiation potency. Our findings further emphasize the need for strategies to purify cell populations with the clinically desired tissue formation potentials.
Computed waveforms in transversely isotropic media II. Horizontal point force (1982)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1982Computed waveforms in transversely isotropic media II. Horizontal point forceAuthors: J. E. WhiteChalermkiat TongtaowCarol MonashJ. E. WhiteColorado School of Mines, Chalermkiat TongtaowColorado School of Mines, and Carol MonashColorado School of Mineshttps://doi.org/10.1190/1.1826871 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1826871FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1982ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1982 Pages: 520 publication data© 1982 Copyright © 1982 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 24 Mar 2005 CITATION INFORMATION J. E. White, Chalermkiat Tongtaow, and Carol Monash, (1982), "Computed waveforms in transversely isotropic media II. Horizontal point force," SEG Technical Program Expanded Abstracts : 167-169. https://doi.org/10.1190/1.1826871 Plain-Language Summary PDF DownloadLoading ...
Effect of Cu on Structural and FF-Behavior of NiTi Shape Memory Alloy (2010)

The functional fatigue behavior of Ti50Ni30Cu20 (at. %) shape memory alloy was investigated after subjecting to cold working and heat-treatment. Copper addition modified the phase transformation behavior with the introduction of B19-phase in the binary NiTi alloy. It was observed that aging after annealing and thermal cycling (-60 to 100)°C significantly effect the transformation temperatures. Observations in optical microscope and scanning electron microscope reveal inhomogeneity in the composition in the form of coarse Cu+Ti-rich precipitates. Investigations under transmission electron microscope showed growth of internally twined martensitic plates in solution treated sample. The phase transformation temperatures were determined with differential scanning calorimeter. The transformation temperatures were shifted towards lower side. Dislocations introduced during cold working and fine precipitation after aging, may be responsible for this change in the transformation characteristics of the material.
Optimal cooperative motion planning for vehicles at intersections (2013)

We consider the problem of cooperative intersection management. It arises in automated transportation systems for people or goods but also in multi-robots environment. Therefore many solutions have been proposed to avoid collisions. The main problem is to determine collision-free but also deadlock-free and optimal algorithms. Even with a simple definition of optimality, finding a global optimum is a problem of high complexity, especially for open systems involving a large and varying number of vehicles. This paper advocates the use of a mathematical framework based on a decomposition of the problem into a continuous optimization part and a scheduling problem. The paper emphasizes connections between the usual notion of vehicle priority and an abstract formulation of the scheduling problem in the coordination space. A constructive locally optimal algorithm is proposed. More generally, this work opens up for new computationally efficient cooperative motion planning algorithms.
Mine hoisting in deep shafts in the 1 st half of 21 st Century (2002)

Ťažne zariadenia v hlbokých sachtach v prvej polovici 21 storocia V prispevku su uvedene vseobecne informacie o hlbokých sachtach prevadzkovaných v Juhoafrickej republike. Prispevok sa tiež venuje opisu možnosti riesenia zvislej dopravy v sachtach hĺbky do 4300 m. Uvedene su aj rozne druhy použivaných ťažných strojov, pricom pozornosť je venovana ťažným strojom typu Blaira. Opisane su jednotlive problemy vyplývajuce z použivania dlhých ťažných lan (ich konstrukcie, nosnosti) a použivani dopravný zariadeniach.
Central effects of N-substituted derivatives of 2,6-dioxopiperidine in mice. (1988)

Pharmacological activities of N-allyl, N-benzyl and N-o-xylyl derivatives of both 2,6-dioxopiperidine (DOP = glutarimide) and 4-ethyl-4-methyl-2,6-dioxopiperidine [bemegride(BG)] were studied in mice. Convulsant activity, hypnotic activity, anticonvulsant activity, acute toxicity and interactions with some hypnotics were used as pharmacological indexes. N-Benzyl-2,6-dioxopiperidine (ByDOP) and N-o-xylyl-2,6-dioxopiperidine (o-XyDOP) exhibited some hypnotic activity. N-Allyl-2,6-dioxopiperidine (ADOP), ByDOP and o-XyDOP prolonged the pentobarbital (PB)-induced sleep by 2.5-, 9- and 4-fold, respectively, as compared with the control at a dose of 80 mg/kg, i.p. On the other hand, N-allylbemegride (ABG) exhibited convulsant activity at a high dose. N-Benzylbemegride (ByBG) and N-o-xylylbemegride (o-XyBG) also showed some hypnotic and anticonvulsant activities. BG (20 mg/kg, i.p.) shortened the amobarbital (AB)- and thiopental (TP)-induced sleep, whereas ABG (80 mg/kg, i.p.) significantly shortened only the barbital (B)-induced sleep, in spite of showing with 20 and 80 mg/kg, i.p. the prolonging effect on the AB- and PB-induced sleep. At a dose of 80 mg/kg, i.p., ByBG significantly prolonged the phenobarbital (PheB)-, AB-, PB-, TP- and glutethimide (GI)-induced sleep, and o-XyBG also showed the prolonging effect on the PheB-, AB-, TP- and GI-induced sleep. These results indicate that ByDOP and o-XyDOP possess some central depressant effect, ABG has antagonistic effect on the B-induced sleep and that substitution of aromatic groups on the N position of BG reduces the convulsant activity but increases the depressant activity.
Poling dynamics and relaxation of polar order in guest/host polymers by second-harmonic generation (1994)

A detailed study of the decay of the second-harmonic generation (SHG) signals of several guest–host nonlinear optical polymer systems has been carried out. The decay of the SHG signal is found to be affected by surface and trapped space charges. A fast component is observed at a low poling field and is found to be mainly due to surface charges which orient the chromophores near the surface. A second component, associated with macroscopic polarization, is induced at high field. The intensity of the second component, which decays considerably slower than the fast component, rapidly increases when the poling field is greater than a threshold voltage. Above the temperature of glass transition Tg, a single exponential function gives a good fit to the shape of the second component of the SHG intensity decay curve. The time constant of the slow component is found to increase with successive poling-decay cycles and reaches a steady-state value after several cycles have been performed. This lengthening effect is found both above and below Tg. Furthermore, the relaxation time of the slow component is also found to depend on the poling field strength: when the host is polymethylmethacrylate, it is found that the relaxation time increases with increasing poling field strength; on the other hand, it decreases with the poling field when polysulfone is used as the host. The temperature dependence of the steady-state relaxation time is not Arrhenius; the Vogel–Fulcher–Tammann equation gives a satisfactory fit to the temperature dependence data.