gebhart/patrepeval huggingface dataset:
Five- and Six-Coordinate Group 4 Compounds Stabilized by <i>β</i>-Ketiminate and Diketiminate Ligands:  Syntheses and Comparisons between Solid-State and Solution Structures (1999)

The preparation and reaction chemistry of beta-diketiminate titanium and zirconium complexes is described. Amine elimination reactions work well for introducing Tolnacnac or Tolnacac to the metal centers (TolnacnacH = 2-(p-tolylamino)-4-(p-tolylimino)-2-pentene; TolnacacH = 4-p-toluidinopent-3-en-2-one). In certain cases, the iminium salt of the diketimine can be used to circumvent the unfavorable reaction kinetics. Salt elimination reactions starting from group 4 metal halides and beta-diketiminate lithium reagents are the most versatile method for introducing beta-diketiminate ligands to the metal. For (beta-diketiminate)MCl(3) compounds (M = Ti, Zr) eta(5)- and eta(2)-coordination modes can be controlled by modifying the diketiminate ligands. Several structures of five- and six-coordinate metal complexes were solved by X-ray diffraction methods. Five-coordinate metal complexes adopt both trigonal bipyramidal and square pyramidal geometries, and the six-coordinate metal complexes possess pseudooctahedral metal centers. For (Tolnacnac)(2)ZrX(2) (X = Cl, OR, NMe(2)) the activation parameters for Lambda/Delta conversion have been probed by dynamic NMR and are consistent with a Bailar-twist mechanism. At a common temperature, the isomerization rates follow the order Cl > OR > NMe(2).
New cyclopentenone fatty acids formed from linoleic and linolenic acids in potato (2000)

[1-14C]Linoleic acid was incubated with a whole homogenate preparation from potato stolons. The reaction product contained four major labeled compounds, i.e., the alpha-ketol 9-hydroxy-10-oxo-12(Z)-octadecenoic acid (59%), the epoxy alcohol 10(S),11(S)-epoxy-9(S)-hydroxy-12(Z)-octadecenoic acid (19%), the divinyl ether colneleic acid (3%), and a new cyclopentenone (13%). The structure of the last-mentioned compound was determined by chemical and spectral methods to be 2-oxo-5-pentyl-3-cyclopentene-1-octanoic acid (trivial name, 10-oxo-11-phytoenoic acid). Steric analysis demonstrated that the relative configuration of the two side chains attached to the five-membered ring was cis, and that the compound was a racemate comprising equal parts of the 9(R),13(R) and 9(S),13(S) enantiomers. Experiments in which specific trapping products of the two intermediates 9(S)-hydroperoxy-10(E),12(Z)-octadecadienoic acid and 9(S),10-epoxy-10,12(Z)-octadecadienoic acid were isolated and characterized demonstrated the presence of 9-lipoxygenase and allene oxide synthase activities in the tissue preparation used. The allene oxide generated from linoleic acid by action of these enzymes was further converted into the cyclopentenone and alpha-ketol products by cyclization and hydrolysis, respectively. Incubation of [1-14C]linolenic acid with the preparation of potato stolons afforded 2-oxo-5-[2'(Z)-pentenyl]-3-cyclopentene-1-octanoic acid (trivial name, 10-oxo-11,15(Z)-phytodienoic acid), i.e., an isomer of the jasmonate precursor 12-oxo-10,15(Z)-phytodienoic acid. Quantitative determination of 10-oxo-11-phytoenoic acid in linoleic acid-supplied homogenates of different parts of the potato plant showed high levels in roots and stolons, lower levels in developing tubers, and no detectable levels in leaves.
Central nervous system agents. 4. Analogs of 3-amino-2-phenylpropiophenone (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCentral nervous system agents. 4. Analogs of 3-amino-2-phenylpropiophenoneRobert Bruce Moffett and Jackson B. HesterCite this: J. Med. Chem. 1972, 15, 12, 1243–1247Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://pubs.acs.org/doi/10.1021/jm00282a010https://doi.org/10.1021/jm00282a010research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Systemic and Local Inflammation in Peritoneal Dialysis: Mechanisms, Biomarkers and Effects on Outcome (2009)

Thanks to the technological development in peritoneal dialysis (PD) during the last three decades, the most important problem nowadays for the nephrologists is the maintenance of the long-term function of the peritoneal membrane. Although PD may exert an early survival benefit as compared with hemodialysis (HD), long-term PD is often associated with histopathological alterations in the peritoneal membrane that are linked to peritoneal ultrafiltration deficit and increased mortality risk. These alterations are closely related to the presence of a chronic activated (local and systemic) inflammatory response. PD itself may have other factors associated that could further modulate the inflammatory response, such as the bioincompatibility of dialysis solutions, fluid overload and changes in the body composition. Understanding the pathophysiology of inflammation in PD is essential for the adoption of adequate strategies to improve both membrane and patient survival.
Static Analysis for Computing Escapability and Mutability for Java Components (2006)

A common theme in information security is protection of trusted software components against unauthorized access by untrusted users. In the context of distributed object technologies, such as Enterprise Java Beans, this means preventing leaks of sensitive information to untrusted users, as well as preventing untrusted users from modifying sensitive information. In this paper, we propose an approach for identification and classification of potentially sensitive information that can leak out of trusted software components to untrusted parties. Unlike the current approaches to securing information flow by extending the type system, our technique is based on static points-to, data- and control-dependence, and object mutability analyses.
The coin lesion of the lung: A review of 955 resected coin lesions (1983)

The retrospective study of 955 coin lesions of the lung showed 49% to be malignant. The proportion of malignant lesions increased with age. In patients older than 60 years of age, 65% of the lesions were malignant; in this group, bronchogenic carcinoma was the most frequent lesion. The delay prior to resection was especially pronounced in both younger patients and in patients with smaller lesions.
Improving the Safety, Scalability, and Efficiency of Network Function State Transfers (2015)

Several frameworks have been proposed to orchestrate the transfer of internal state between network function (NF) instances. Unfortunately, these frameworks suffer from safety, efficiency, and scalability problems due to their excessive use of packet buffering. We propose two novel enhancements, packet reprocessing and peer-to-peer transfers, to address these issues. We show these enhancements reduce the average per-packet latency overhead by up to 92% and state transfer times by up to 70%.
HIGH TITERS OF IgG ANTIBODIES AGAINST PLASMODIUM FALCIPARUM SERINE REPEAT ANTIGEN 5 (SERA5) ARE ASSOCIATED WITH PROTECTION AGAINST SEVERE MALARIA IN UGANDAN CHILDREN (2006)

Plasmodium falciparum serine repeat antigen (SERA5) is a promising asexual blood stage malaria candidate vaccine. However, there is a paucity of information about natural immune responses to SERA5 in children from malaria-endemic regions. We undertook a hospital-based case-control study of severe malaria in Apac District, Northern Uganda, in children 6-59 months of age. The commonest symptoms observed in children with severe malaria (SM) were respiratory distress (53.4%) and prostration (40.4%) followed by circulatory collapse (7.4%), severe anemia (Hb < 5 g/dL, 7.0%), and seizures (2.6%). None of the SM children had impaired consciousness, coma, or cerebral malaria. We measured serum IgG antibodies using a recombinant construct of SERA5 (SE36) in enzyme-linked immunosorbent assays. High titers of IgG anti-SE36 were associated with protection against severe malaria in children under 5 years old.
Administración de la jurisdicción (1967)

Una mala jugada de nuestra memoria infiel nos ha sustraido el nombre del autor de la frase que sirve de titulo a este modesto trabajo. Anticipamos esto para dejar a salvo la paternidad de la misma, sumamente acertada por lo que tiene de expresiva y sintetica. Esta expresividad sirve de adelantado para que el lector, desde un primer momento, se haga cargo del tema que vamos a desarrollar: el de un determinado tipo de actividad administrativa al servicio de la Jurisdiccion. El tema para nosotros es doblemente sugestivo, en cuanto que pone en juego materias intimamente ligadas a nuestro cotidiano profesional quehacer. Lo importante, sin embargo, es que sea atrayente para los demas, para la mayoria de los juristas, o, por lo menos, para los que de una u otra forma se relacionan con la actividad jurisdiccional. Sobre todo, y aun a riesgo de pasar por presuntuoso, el tema lo encontramos oportuno, como punto de meditacion, con miras a un perfeccionamiento del Poder judicial de nuestro pais (1). Es un tema, pues, no solamenle relevante desde el punto de vista teorico, sino util, si se piensa en la praxis judicial espanola. Queremos destacar, de otro lado, que el tema elegido obliga a un examen de la Administracion desde un plano singular y objetivo : en su con-
[Geometrical dummy used for ergonomic evaluation on early stage cockpit conceptual design]. (2001)

Objective. Basing on the need of cockpit ergonomic design, to set up a geometrical dummy. Method. Surface partition of the dummy, source of the curved face data, express of the curved face, degree of freedom of the human joint, coordinate system of the parts, position of the human segment centroid and weight of the human segment were cleared up first, then geometrical dummy was displayed with three-dimensional software. Result. The geometrical dummy could simulate some basic body movements and postures for ergonomic analysis. Conclusion. The geometrical dummy was suitable for present study and engineering design.
Increased expression of protein C-mannosylation in the aortic vessels of diabetic Zucker rats (2004)

C-Mannosylation is a novel type of glycosylation in proteins. There are several examples of proteins in which the specific motif Trp-X-X-Trp is mannosylated at the first Trp to produce C-mannosylated Trp (CMW). Although C-mannosylation modifies Trp-X-X-Trp, predicted to be a functional motif of various integral proteins such as cytokine receptors, the physiological or pathological relevance of C-mannosylation in the cell is still not known. In this study, to characterize C-mannosylation in biological samples, we generated specific polyclonal antibodies against CMW by using a chemically synthesized CMW as an antigen. Using the antibody, we investigated the effect of hyperglycemic conditions on protein C-mannosylation in cultured cells and diabetic Zucker fatty rats. We found that protein C-mannosylation was increased in macrophage-like RAW264.7 cells under hyperglycemic conditions compared to low-glucose conditions. Furthermore, C-mannosylation was increased in the aortic vessel wall of Zucker fatty rats. Thrombospondin-1 was identified as a protein modified with C-mannosylation, and its expression was also increased in the aortic tissues of Zucker fatty rats. These results indicate that C-mannosylation is increased in specific tissues or cell types under hyperglycemic conditions, suggesting a pathological role for the increased C-mannosylation in the development of diabetic complications.
Analysis of the Internet Key Exchange protocol using the NRL Protocol Analyzer (2003)

We show how the NRL Protocol Analyzer, a special-purpose formal methods tool designed for the verification of cryptographic protocols, was used in the analysis of the Internet Key Exchange (IKE) protocol. We describe some of the challenges we faced in analyzing IKE, which specifies a set of closely related subprotocols, and we show how this led to a number of improvements to the Analyzer. We also describe the results of our analysis, which uncovered several ambiguities and omissions in the specification which would have made possible attacks on some implementations that conformed to the letter, if not necessarily the intentions, of the specifications.
Efficient GAN-Based Anomaly Detection (2018)

Generative adversarial networks (GANs) are able to model the complex highdimensional distributions of real-world data, which suggests they could be effective for anomaly detection. However, few works have explored the use of GANs for the anomaly detection task. We leverage recently developed GAN models for anomaly detection, and achieve state-of-the-art performance on image and network intrusion datasets, while being several hundred-fold faster at test time than the only published GAN-based method.
Synthesis of 2-Amino-4-(4-pyridinyl)-1,3,5-triazine and Its Novel Reaction with Isocyanates (1992)

The reaction of the sodium salt of 2-amino-4-(4-pyridiny1)-1,3,5-triazine (4) with L-hutyl, isopropyl, phenyl, and E-chlorophenyl isocyanates formed the corresponding N-(alkyl or ary1)-2-amino-4-(4-pyr-idiny1)-1,3,5-triazines (6) whereas the reaction with methyl isocyanate and propyl isocyanate formed the expected E-alkyl-E'-14-(4-pyridiny1)- 1.3.5-triazin-2-yllureas(7).1 Several years ago, we reported the synthesis and entiallergic activity of E-alkyl-E'-12-1
SMART Mobility. Advanced Fueling Infrastructure Capstone Report (2020)

The U.S. Department of Energy’s Systems and Modeling for Accelerated Research in Transportation (SMART) Mobility Consortium is a multiyear, multi-laboratory collaborative, managed by the Energy Efficient Mobility Systems Program of the Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office, dedicated to further understanding the energy implications and opportunities of advanced mobility technologies and services. The first three-year research phase of SMART Mobility occurred from 2017 through 2019 and included five research pillars: Connected and Automated Vehicles, Mobility Decision Science, Multi-Modal Freight, Urban Science, and Advanced Fueling Infrastructure. A sixth research thrust integrated aspects of all five pillars to develop a SMART Mobility Modeling Workflow to evaluate new transportation technologies and services at scale. This report summarizes the work of the Advanced Fueling Infrastructure Pillar. This Pillar investigated the charging infrastructure needs of electric ride-hailing and car-sharing vehicles, automated shuttle buses, and freight-delivery truck fleets. For information about the other Pillars and about the SMART Mobility Modeling Workflow, please refer to the relevant Pillar’s Capstone Report.
Characteristics of peptide and major histocompatibility complex class I/beta 2-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2). (1994)

The transporter proteins associated with antigen processing (TAP proteins) transport antigenic peptides across the endoplasmic reticulum membrane where they can assemble with newly synthesized major histocompatibility complex (MHC) class I/beta 2-microglobulin (beta 2m) dimers. We have shown previously that TAP possesses a peptide-recognition site with broad specificity and that MHC class I/beta 2m dimers physically associate with TAP. Here, we further characterize the nature of the peptide-binding site on TAP, and the site of interaction of TAP with MHC class I/beta 2m dimers. TAP photoaffinity labeling experiments revealed that both TAP1 and TAP2 are photolabeled by two distinct photopeptide analogues, suggesting that elements of both TAP1 and TAP2 compose the peptide-recognition site. TAP photolabeling analysis on transfectant cell lines that express TAP1 and TAP2 both individually and together revealed that efficient formation of the peptide-binding site occurs only when TAP1 and TAP2 are coexpressed, which correlates with the finding that peptide translocation via TAP occurs only in the presence of both TAP1 and TAP2. These data strongly support the notion that TAP functions as a heterodimer. MHC class I/beta 2m dimers were shown to associate with individual TAP1 chains but were not detectable with individual TAP2 chains. This result suggests that the site of interaction for MHC class I/beta 2m dimers with TAP is on TAP1.
Ion-selective electrodes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIon-selective electrodesMark E. Meyerhoff and Yvonne M. FraticelliCite this: Anal. Chem. 1982, 54, 5, 27–44Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://doi.org/10.1021/ac00242a004Request reuse permissions Article Views698Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) Get e-Alertsclose Get e-Alerts
<title>HSI mapping of marine and coastal environments using the advanced airborne hyperspectral imaging system (AAHIS)</title> (1997)

The advanced airborne hyperspectral imaging system (AAHIS) is an operational, high signal-to-noise ratio, high resolution, integrated hyperspectral imaging spectrometer. The compact, lightweight and portable AAHIS system is normally flown in Piper Aztec aircraft. AAHIS collect 'push- broom' data with 385 spatial channels and 288 simultaneous spectral channels from 433 nm to 832 nm, recording at 12 bits up to 55 frames/second. Typical operation incorporates on-chip pixel binning of four pixels spectrally and two pixels spatially, increasing the signal-to-noise ratio and reducing data rate. When binned, the spectral resolution is 5.5 nm and the instantaneous field-of-view is 1 mrad, resulting in a ground sample distance of 0.5 m from 500 m altitude. The sensor is optimized for littoral region remote sensing for a variety of civilian and defense applications including ecosystem surveying and inventory, detection and monitoring of environmental pollution, infrastructure mapping, and surveillance. Since August 1994, AAHIS has acquired over 120 GB of hyperspectral image data of littoral, urban, desert and tropical scenes. System upgrades include real-time spectral image processing, integrated flight navigation and 3-axis image stabilization. A description of the sensor system, its performance characteristics, and several processed images demonstrating material discrimination are presented. The remote assessment, characterization, and mapping of coral reef health and species identification and floral species at Nu'upia Ponds, are shown and compared to extensive ground truthing in and around Kaneohe Bay, Oahu, Hawaii. SETS emphasizes providing georegistered, GIS-integrated, value- added data products for customers to help them solve real- world problems.
Long-term antihistamine use: making the right choice for your patient (2015)

Spring is in the air, and with it:
• Sneezing
• Postnasal drip and coughing
• Runny noses
• Itching of the nose, eyes, throat and ears
• Nasal congestion
• General irritability and fatigue.

These symptoms are reported by patients with allergic rhinitis. Allergic rhinitis is often ignored, misdiagnosed or mistreated, and has a negative impact on quality of life, quality of sleep and productivity, and can also cause or worsen asthma. Although allergic rhinitis mostly occurs as a seasonal condition, it can also persist throughout the year. It may even be a lifelong condition for some people, with the symptoms waxing and waning over time. Therefore, the trend is to treat these patients with long-term therapy, rather than treating them intermittently. Antihistamines reduce itching, sneezing and a runny nose, but have less of an effect on nasal congestion. Since they are among the most widely prescribed and safest drugs in the world, second-generation antihistamines remain the first-line option for the oral treatment of many allergic conditions.
<title>Multispectral infrared Stokes imaging polarimeter</title> (1999)

We describe the design and development of an imaging polarimeter that will simultaneously measure Stokes vector images in the mid-wave IR and long-wave IR wavebands. We present an analysis of the expected errors that arise due to spectral variations in the polarization elements of the instrument across each waveband. FInally, instrument calibration and polarization images acquired in the MWIR waveband are presented.
Diphtheria toxin and its ADP-ribosyltransferase-defective homologue CRM197 possess deoxyribonuclease activity. (1990)

The cytotoxic mechanism of diphtheria toxin (DTx) is associated with its ability to inhibit protein synthesis by ADP-ribosylation of elongation factor 2. Although DTx intoxication leads to internucleosomal DNA cleavage and cell lysis, these events do not occur when protein synthesis is inhibited by alternative treatments (e.g., cycloheximide). Here we show that endonucleolytic degradation of DNA is an intrinsic activity of DTx and also of the crossreactive mutant protein CRM197. Assays using DNA-impregnated gels as well as linear and supercoiled DNA in solution revealed not only that CRM197 has nuclease activity but also that its specific activity is actually significantly greater than that of the wild-type molecule. Since CRM197 contains a single amino acid substitution that renders it incapable of ADP-ribosylation, we propose that the active sites for ADP-ribosyltransferase and nuclease activities are distinct.