gebhart/patrepeval huggingface dataset:
The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9 (2000)

Chemokines are key regulators of migration in lymphoid tissues. In the thymus, maturing thymocytes move from the outer capsule to the inner medulla and thereby interact with different types of stromal cells that control their maturation and selection. In the process of searching for molecules specifically expressed at different stages of mouse thymic differentiation, we have characterized the cDNA coding for the thymus-expressed chemokine (TECK) and its receptor CCR9. The TECK receptor gene was isolated and shown to be localized on the mouse chromosome 9F1-F4. Thymic dendritic cells have been initially thought to be a prevalent source of TECK. In contrast, our results indicate that thymic epithelial cells constitute the predominant source of TECK. Consistent with the latter distribution, the TECK receptor is highly expressed by double-positive thymocytes, and TECK can chemoattract both double-positive and single-positive thymocytes. The TECK transcript is also abundantly expressed in the epithelial cells lining the small intestine. In conclusion, the interplay of TECK and its receptor CCR9 is likely to have a significant role in the recruitment of developing thymocytes to discrete compartments of the thymus.
Treatment of Experimental Gram-Negative and Gram-Positive Bacterial Sepsis with the Hematoregulatory Peptide SK&F 107647 (1996)

SK&F 107647, a novel synthetic low-molecular-weight peptide, has demonstrated potent antiinfective activities in murine models of fungal and viral infection. To determine if the hematoregulatory activities of SK&F 107647 could offer protection over conventional antibiotic therapy or as a single agent in animal models of bacterial sepsis, rats were implanted intraperitoneally with a live bacteria-containing fibrin-thrombin clot. Rats pretreated subcutaneously or orally with SK&F 107647 and then infected with either a gram-negative (Escherichia coli) or a gram-positive (Staphylococcus aureus) bacteria-containing clot demonstrated significantly improved survival over control formulation-treated animals. Treated animals showed increased effector cell activation, measured by CD11b expression on neutrophils and monocytes, and up to 1000-fold reduction in the number of E. coli recovered from blood. Thus, the hematoregulatory activities of SK&F 107647 can increase natural host resistance to infections caused by both gram-negative and gram-positive bacteria.
POSTNATAL CHANGES IN THE CALCIUM BINDING PROTEINS OF MOUSE TESTIS (2001)

To define the changes in calcium-binding proteins (CBPs) of mouse testis during postnatal development, testicular protein extracts were analyzed by mobility shift after Ca2+ binding (MSACB) in the 2-dimensional SDS-PAGE. In the adult testis extracts, 29 kinds of protein spots showed mobility shift in the gel containing Ca2+. Among them, 2 spots showed nonspecific mobility shift and 4 spots showed Zn2+ shift. Drastic changes in expression of high-Mr CBPs (Mr > 25 kDa) were observed in testis 3 weeks after birth, suggesting that their expressions were developmentally changed. There was no obvious difference in the qualitative patterns of CBP between 4-week-old testis and adult testis. There was a large mass of CBPs (Mr = 20-25 kDa) expressed constitutively in testis throughout the postnatal development. Degree of MSACB (Mr on the diagonal line/Mr of shifted point in Ca2+ gel) of each spot was in the range of 1.1-1.7 in 12% acrylamide gel. These results suggest that changes in CBPs of testis are closely related with progression of spermatogenesis in mouse testis.
Large public display boards: a case study of an OR board and design implications. (2001)

A compelling reason for studying artifacts in collaborative work is to inform design. We present a case study of a public display board (12 ft by 4 ft) in a Level-I trauma center operating room (OR) unit. The board has evolved into a sophisticated coordination tool for clinicians and supporting personnel. This paper draws on study findings about how the OR board is used and organizes the findings into three areas: (1) visual and physical properties of the board that are exploited for collaboration, (2) purposes the board was configured to serve, and (3) types of physical and perceptual interaction with the board. Findings and implications related to layout, size, flexibility, task management, problem-solving, resourcing, shared awareness, and communication are discussed in an effort to propose guidelines to facilitate the design of electronic, computer driven display boards in the OR environment.
QoS-based resource allocation scheme for Device-to-Device (D2D) radio underlaying cellular networks (2012)

Device-to-Device (D2D) communication underlaying cellular network is considered to be a promising resource reuse technique, and it is basically developed for lots of local services. Considering the differences of the quality of services (QoS) between cellular and D2D users, the resource allocation scheme for D2D should flexibly allocate resource for D2D, rather than limiting one D2D user to share resource with one cellular user. A QoS-based resource allocation scheme for D2D users in the context of an OFDM-based air interface is proposed. This scheme exploits the QoS information, especially the rate target of users, to allocate sufficient resource as need. In addition, the system efficiency can be improved as the proposed resource allocation scheme always select the most efficient resource for D2D users. Numerical results corroborate that the proposed scheme can fulfill D2D user's QoS requirements effectively, and meanwhile accommodate different QoS requirements flexibly.
AN INTEGRATED SCORE-BASED TRAFFIC LAW ENFORCEMENT AND NETWORK MANAGEMENT IN CONNECTED VEHICLE ENVIRONMENT (2020)

The increasing number of traffic accidents and the associated traffic congestion have prompted the development of innovative technologies to curb such problems. This dissertation introduces a novel Score-Based Traffic Law Enforcement and Network Management System (SLEM), which leverages connected vehicle (CV) and telematics technologies. SLEM assigns a score to each driver which reflects her/his driving performance and compliance with traffic laws over a predefined period of time. The proposed system adopts a rewarding mechanism that rewards high-performance drivers and penalizes low-performance drivers who fail to obey traffic laws. The reward mechanism is in the form of a route guidance strategy that restricts low-score drivers from accessing certain roadway sections and time periods that are strategically selected in order to shift the network traffic distribution pattern from the undesirable user equilibrium (UE) pattern to the system optimal (SO) pattern. Hence, it not only incentivizes drivers to improve their driving performance, but it also provides a mechanism to manage network congestion in which high-score drivers experience less congestion and a higher level of safety at the expense of low-performing drivers. This dissertation is divided into twofold. iv First, a nationwide survey study was conducted to measure public acceptance of the SLEM system. Another survey targeted a focused group of traffic operation and safety professionals. Based on the results of these surveys, a set of logistic regression models was developed to examine the sensitivity of public acceptance to policy and behavioral variables. The results showed that about 65 percent of the public and about 60.0 percent of professionals who participated in this study support the real-world implementation of SLEM. Second, we present a modeling framework for the optimal design of SLEM’s routing strategy, which is described in the form of a score threshold for each route. Under SLEM’s routing strategy, drivers are allowed to use a particular route only if their driving scores satisfy the score threshold assigned to that route. The problem is formulated as a bi-level mathematical program in which the upper-level problem minimizes total network travel time, while the lower-level problem captures drivers’ route choice behavior under SLEM. An efficient solution methodology developed for the problem is presented. The solution methodology adopts a heuristic-based approach that determines the score thresholds that minimize the difference between the traffic distribution pattern under SLEM’s routing strategy and the SO pattern. The framework was applied to the network of the US-75 Corridor in Dallas, Texas, and a set of simulation-based experiments was conducted to evaluate the network performance given different driver populations, score class aggregation levels, recurrent and non-recurrent congestion scenarios, and driver compliance rates.
Envelope-finite-element (EVFE) technique - a more efficient time-domain scheme (2001)

A novel technique, called the envelope-finite element (EVFE) method, is proposed as a more efficient full-wave time-domain modeling scheme of electromagnetic waves. The EVFE method simulates the signal envelope rather than the original signal waveform by de-embedding the signal carrier from the time-domain wave equation. The de-embedded equation is then solved in the time domain using finite-element methods based on Newmark-Beta time stepping. Compared to traditional time-domain simulation techniques such as finite difference time-domain or finite element time-domain methods, only the signal envelope needs to be sampled in EVFE simulation. This method can reduce computation time when signal envelope/carrier ratios are very small. The purpose of this paper is to introduce this new concept, by presenting the two-dimensional EVFE formulations, stability conditions, and some supporting numerical examples.
A novel inorganic photoresist utilizing Ag photodoping in Se-Ge glass films (1976)

By ’’photodoping’’ with silver, chalcogenide glasses become almost insoluble in alkaline solutions. This letter examines the applicability of this effect to silicon microfabrication technology. Suitable processing techniques and exposure characteristics are investigated. It is shown that the (Ag) -Se-Ge glass system can be used as a negative-type photoresist; fine pattern photoetching of less than 1 μm line width in SiO2 is easily achieved. This inorganic photoresist has some advantages over the conventional polymer-type photoresists in resolution, etch resistance to acid solutions, and process reproducibility.
Pixelless infrared imaging utilizing a p-type quantum well infrared photodetector integrated with a light emitting diode (1997)

We present experimental results which support a recently proposed scheme for infrared imaging through the combined use of a photon frequency up-conversion device with a charge coupled device (CCD) camera. The epitaxial device consists of a long wavelength p-type GaAs/AlGaAs quantum well infrared photodetector (QWIP) on top of which is grown a shorter wavelength InGaAs/GaAs light emitting diode (LED). Upon long wavelength infrared excitation of the QWIP, near infrared light is generated by the LED whose output is directed towards a commercial CCD array where the up-converted image of the long wavelength infrared source object is formed.
Random dot markers (2011)

This paper presents a novel approach for detecting and tracking markers with randomly scattered dots for augmented reality applications. Compared with traditional markers with square pattern, our random dot markers have several significant advantages for flexible marker design, robustness against occlusion and user interaction. The retrieval and tracking of these markers are based on geometric feature based keypoint matching and tracking. We experimentally demonstrate that the discriminative ability of forty random dots per marker is applicable for retrieving up to one thousand markers.
A fast parallel multiplier architecture (2003)

A parallel multiplier architecture is presented that is both fast and small and a viable alternative to the array and tree type multipliers. The speed of this architecture is close to that of the binary and Wallace tree architectures for common sizes of multipliers, while the area is only marginally larger than that of the array multiplier. The structure of the architecture is very regular, making it ideal for automatic generation. The internal structure of this floorplan can be generated very easily from a set of seven VLSI leafcells requiring no extra routing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Identification and preliminary characterization of external membrane-bound nuclease activities in Mycoplasma pulmonis (1986)

Mycoplasma pulmonis has substantial DNase activity exposed on the cell surface. At least part of this activity is attributable to an endonuclease. The activity is destroyed at 56 degrees C and inhibited by either 5 mM EDTA or 10 mM zinc chloride. It can also be eliminated by treatment of intact organisms with trypsin and is regenerated by incubation of the treated organisms in a medium that supports protein synthesis. DNase exposed at the cell surface constitutes 20% of the total DNase activity present in M. pulmonis extracts.
Using a manipulator for force display in molecular docking (2003)

A real-time molecular docking system is developed that uses an electrically coupled remote manipulator as a force display. The system, which uses integrates interactive computer graphics and high-speed calculation of the interaction forces between a drug and a receptor site in a molecule, is designed to be a tool for molecular scientists. The manipulator is used to generate the forces and torques exerted on the drug molecule when it is aligned with the receptor site by the user's hand. The manipulator serves both as an input device for 6-D manipulation and as an output device for generating forces. Preliminary testing indicates that the system might enhance the biochemist's understanding and performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Identification of a Potent, Selective, and Orally Active Leukotriene A<sub>4</sub> Hydrolase Inhibitor with Anti-Inflammatory Activity (2008)

LTA 4H is a ubiquitously distributed 69 kDa zinc-containing cytosolic enzyme with both hydrolase and aminopeptidase activity. As a hydrolase, LTA 4H stereospecifically catalyzes the transformation of the unstable epoxide LTA 4 to the diol LTB 4, a potent chemoattractant and activator of neutrophils and a chemoattractant of eosinophils, macrophages, mast cells, and T cells. Inhibiting the formation of LTB 4 is expected to be beneficial in the treatment of inflammatory diseases such as inflammatory bowel disease (IBD), asthma, and atherosclerosis. We developed a pharmacophore model using a known inhibitor manually docked into the active site of LTA 4H to identify a subset of compounds for screening. From this work we identified a series of benzoxazole, benzthiazole, and benzimidazole inhibitors. SAR studies resulted in the identification of several potent inhibitors with an appropriate cross-reactivity profile and excellent PK/PD properties. Our efforts focused on further profiling JNJ 27265732, which showed encouraging efficacy in a disease model relevant to IBD.
Improved Porous Mixture of Molybdenum Nitride and Tantalum Oxide as a Charge Storage Material (1998)

High surface area γ‐molybdenum nitride has shown promise as a charge storage material. The addition of amorphous tantalum oxide to the molybdenum nitride system not only improves the film cohesion tremendously, but also widens the voltage stability window from 0.8 to 1.1 V. This occurs without adversely effecting the capacitance.
Ophiobolin A. A natural product inhibitor of calmodulin. (1984)

Ophiobolin A, a fungal metabolite and a phytotoxin which can stimulate the net leakage of electrolytes and glucose from maize seedling roots (Tipton, C. L., Paulsen, P. V., and Betts, R. E. (1977) Plant Physiol. 59, 907-910) was found to be a potent inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase. The physiologically less active analogue, 3-anhydro-ophiobolin A, was found to be less inhibitory than ophiobolin A in the phosphodiesterase assay. The direct interaction between ophiobolin A and calmodulin has been demonstrated by changes in fluorescence of the protein and by the effect of ophiobolin A on calmodulin activity upon preincubation. Addition of ophiobolin A to calmodulin solutions resulted in an instantaneous quenching of the intrinsic tyrosine fluorescence followed by a time-dependent quenching. The instantaneous quenching is probably due to the inner filtering effect of ophiobolin A. The time-dependent fluorescence quenching was correlated with a time-dependent inhibition of calmodulin upon preincubation with ophiobolin A. The inhibition of calmodulin by ophiobolin A could not be reversed by dialysis, dilution, nor denaturation by urea in the presence of methanol followed by renaturation, and was much more pronounced in solutions containing Ca2+ than in those containing EGTA. Ophiobolin A also was shown to inhibit spinach calmodulin. The results of the present study suggest that calmodulin may be one of the target proteins of the phytotoxic action of ophiobolin A and that the interaction of ophiobolin A with calmodulin may involve a covalent modification of the protein by the fungal metabolite.
Dewatering of coal fines using a super absorbent polymer (2003)

In most coal preparation processes, water is a necessary medium, but the presence of water in coal after it has been cleaned has a negative impact on transportation costs, handling and specific energy values. The utilization of super absorbent polymers (SAP) in the nappy application is well known. The concept of utilizing these polymers was investigated for the purposes of dewatering coal and other fines, generated by preparation processes such as flotation. SAPs are granular highly cross-linked synthetic copolymers with excellent water-absorbing properties. The dewatering process is characterized by three main stages: (a) contact of super absorbent polymer with high-moisture fine coal; (b) separation of dewatered fine coal from super absorbent polymer; and (c) regeneration of used super absorbent polymer, by exploiting its response to changes in conditions such as pH or temperature. Preliminary tests showed the separation step to be very difficult. The novel idea of encasing a given amount of polymer in a water permeable cloth solved this problem (of separating the swollen polymer from the dewatered coal). Preliminary tests investigating the effectiveness of the sachets of polymer showed a drastic decrease in the moisture contents of slurries. Furthermore, it was shown that it was possible to regenerate the polymer (still within the sachets) through thermal drying. A full-scale experimental programme was then followed to accurately determine the feasibility of using sachets of SAP. The experimental variables were initial slurry moisture content and polymer dosage. It was observed that the sachets seemed to work fastest and most effectively at high moistures and also at higher dosages of SAP. Regeneration of the polymer was also investigated, using two methods: thermal regeneration and pH-induced regeneration. The experimental variables, for investigating the regeneration process, were method of regeneration and grade of water used. Thermal regeneration at 70i?½C seemed to work successfully. Although the cost of using thermal energy is still a problem, the safety aspect (fire hazards) has been addressed since the polymer does not ignite when heated, unlike fine coal particles that may do so. The alternative method of regeneration, which exploits the pHsensitivity of the polymer, was less successful, and further work needs to be conducted.
Accuracy of Transmission Line Modeling Based on Aerial LiDAR Survey (2008)

Aerial LiDAR survey is receiving wide application in transmission-line modeling due to its efficiency. The technique is particularly useful for modeling of existing lines for the purpose of thermal rating, upgrading, or vegetation management. An accurate modeling of an existing line depends largely on proper determination of the base conductor temperature, i.e. the conductor temperature at the time of the aerial light detection and ranging (LiDAR) survey. In this paper, an acceptable accuracy for the base conductor temperature is first established. Extensive parametric studies are then conducted to reveal the effects of all the potentially major factors: ambient air temperature, electrical load, solar radiation, wind, and conductor size on the base conductor temperature. As a result, recommendations are made on the proper practice of performing an aerial LiDAR survey and determining the base conductor temperature so that the resulting transmission line modeling is within an acceptable accuracy. It is demonstrated that a wide error can easily be introduced without following a proper procedure for the LiDAR survey.
Electrospray-ionization time-of-flight mass spectrometry in protein chemistry (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrospray-ionization time-of-flight mass spectrometry in protein chemistryOlga A. Mirgorodskaya, Andrew A. Shevchenko, Igor V. Chernushevich, Alexander F. Dodonov, and Anatoliy I. MiroshnikovCite this: Anal. Chem. 1994, 66, 1, 99–107Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://doi.org/10.1021/ac00073a018RIGHTS & PERMISSIONSArticle Views297Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (943 KB) Get e-Alerts Get e-Alerts
Venous Access for Chronic Hemodialysis: “Undesirable Yet Unavoidable” (2004)

Venous angioaccess for hemodialysis is fundamental in order to perform uninterrupted renal replacement therapy. This review focuses on catheter and port devices used for chronic dialysis. Handling, care, and complications are reviewed for both types of venovenous access.