gebhart/patrepeval huggingface dataset:
A study of autonomous data coherency protocol for mobile devices (2003)

An optimistic consistency scheme has been established with respect to data consistency and availability in distributed systems. Wireless networks are becoming popular in data communication and suitable for data sharing among users using multicast capability, but have hidden node problems. This paper proposes a simple data coherency protocol for mobile devices that has less data traffic in data collaboration using a multicast communication feature and is capable of automatic recovery from unpredictable disconnection, such as hidden node problems, by a data versioning scheme using a version vector and update log management. We evaluated the efficiency of data sharing over multicast communication and the recovery cost from failure caused by hidden nodes and confirmed the efficiency of the protocol.
A High-Voltage Generation Charge-Pump IC Using Input Voltage Modulated Regulation for Neural Implant Devices (2018)

This brief presents a high-voltage generation charge pump integrated circuit (IC) with a novel regulation scheme for neural stimulation applications. Instead of using a widely used pulse frequency modulation approach with a variable clock frequency for regulation, an input voltage modulated regulation with a low drop-out regulator at the input of the feedforward path is used to maintain the charge pump output voltage with varying load current between 10 μA to 1 mA. The proposed charge pump IC, implemented with 0.18-μm standard low-voltage CMOS process, reliably generates 12.8-V output voltage from a 2.8-V input and achieves more than 80% power efficiency at 1 mA load condition. The proposed IC occupies 0.6 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of core die area.
Electrophysiologic Evidence for Increased Endogenous GABAergic but Not Glycinergic Inhibitory Tone in the Rat Spinal Nerve Ligation Model of Neuropathy (2001)

These results support the idea of an increased GABAergic inhibitory tone in the spinal cord of neuropathic rats, possibly as compensation for increased excitability after nerve injury.
The development of hydrogen sensor technology at NASA Lewis Research Center (1993)

The detection of hydrogen leaks in aerospace applications, especially those involving hydrogen fuel propulsion systems, is of extreme importance for reasons of reliability, safety, and economy. Motivated by leaks occurring in liquid hydrogen lines supplying the main engine of the Space Shuttle, NASA Lewis has initiated a program to develop point-contact hydrogen sensors which address the needs of aerospace applications. Several different approaches are being explored. They include the fabrication of PdAg Schottky diode structures, the characterization of PdCr as a hydrogen sensitive alloy, and the use of SiC as a semiconductor for hydrogen sensors. This paper discusses the motivation behind and present status of each of the major components of the NASA LeRC hydrogen sensor program.
Intravenous immunoglobulin in the treatment of systemic juvenile rheumatoid arthritis: a randomized placebo controlled trial. Pediatric Rheumatology Collaborative Study Group. (1994)

Our results suggest that high dose IVIG has limited clinical utility in systemic JRA. However, this trial failed to enroll adequate numbers of patients to permit valid statistical intergroup comparisons, and the results must be considered nondefinitive.
Conformal Miniaturization of Domains with Low Domain-Wall Energy: Monoclinic Ferroelectric States near the Morphotropic Phase Boundaries (2003)

A theory is developed for intermediate monoclinic (FE(m)) phases near morphotropic phase boundaries in ferroelectrics of complex oxides. It is based on the conformal miniaturization of stress-accommodating tetragonal domains under the condition of low domain-wall energy density. The microdomain-averaged lattice parameters are determined and attributed to the parameters of an adaptive monoclinic phase. The theory is applied to the temperature, electric field, and compositional dependent FE(m) lattice parameters. The predictions of the theory are rigidly obeyed over the entire FE(m) stability range.
Fetal Cells Traffic to Injured Maternal Myocardium and Undergo Cardiac Differentiation (2011)

Fetal maternal stem cell transfer appears to be a critical mechanism in the maternal response to cardiac injury. Furthermore, we have identified Cdx2 cells as a novel cell type for potential use in cardiovascular regenerative therapy.
Rapid and sensitive method for detection of<i>Salmonella</i>strains using a combination of polymerase chain reaction and reverse dot-blot hybridization (1993)

We have developed a reverse dot-blot hybridization assay for detection of Salmonella using Salmonella-specific oligonucleotide probes designed from the base sequence of the 16S rRNA gene (rDNA). The target fragment of 16S rDNA was amplified, and labelled with biotin by the polymerase chain reaction. The amplified fragment was hybridized with the membrane-immobilized probe and the hybridization was detected by chemiluminescence. Amplified fragments from 24 different serovars of Salmonella hybridized with the probes, whereas those of species of Enterobacteriaceae, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus failed to hybridize. By this assay, it was possible to detect in the order of 10(4) bacteria in fish meat homogenate in 10 h.
Study of protein aggregation using two‐dimensional correlation infrared spectroscopy and spectral simulations (2004)

Two-dimensional (2D) correlation spectroscopy establishes correlations between intensity variations in a series of spectra obtained by the application of an external perturbation. However, spectral effects (wavenumber shift or bandwidth change) are known to generate apparent asynchronisms in 2D maps. Surprisingly, spectral effects are often neglected in the literature when interpreting experimental maps, which can lead to erroneous conclusions. In an attempt to evaluate the contribution of these effects and that of true asynchronisms on 2D maps, the heat-induced aggregation of glutamyl-tRNA synthetase (GluRS) was studied as a typical example of the application of Fourier transform infrared (FTIR) spectroscopy in the amide I region. The data were compared with those obtained from a mutant protein that differs by one amino acid. To determine whether the aggregation mechanisms are identical for both proteins, the experimental 2D maps were compared to simulations based on curve fitting of the initial and final spectra of the series, which allows change in position and bandwidth of the components to be taken into account. Intermediate spectra were generated using a convenient function that mimics the spectral evolution. The speed and the delay of each component were controlled. Apart from the appearance of turns that occur for the mutant and not for GluRS, the aggregation mechanisms of both proteins seems to be essentially identical. In particular, the loss of alpha-helices seems to be concomitant with the formation of intermolecular beta-sheets, whereas the loss of intramolecular beta-sheets is delayed. Since the experimental maps are satisfactorily simulated when almost all the components are in phase, it appears that many of the asynchronous features are mainly due to spectral effects. Thus, one has to be aware that true asynchronisms are not necessarily at the origin of peaks observed in asynchronous maps.
Genetic diversity within Lactobacillus sakei and Lactobacillus curvatus and design of PCR primers for its detection using randomly amplified polymorphic DNA (1999)

The genotypic and phenotypic diversity among isolates of the Lactobacillus curvatus/Lactobacillus graminis/Lactobacillus sakei group was evaluated by comparing RAPD data and results of biochemical tests, such as hydrolysis of arginine, D-lactate production, melibiose and xylose fermentation, and the presence of haem-dependent catalase. Analyses were applied to five type strains and to a collection of 165 isolates previously assigned to L. sakei or L. curvatus. Phenotypic and RAPD data were compared with each other and with previous DNA-DNA hybridization data. The phenotypic and genotypic separation between L. sakei, L. curvatus and L. graminis was clear, and new insights into the detailed structure within L. sakei and L. curvatus were obtained. Individual strains could be typed by RAPD and, after the elimination of similar or identical isolates, two sub-groups in both L. curvatus and L. sakei were defined. The presence or absence of catalase activity further distinguished the two L. curvatus sub-groups. By cloning and sequencing specific RAPD products, pairs of PCR primers were developed that can be used to specifically detect L. curvatus, L. sakei and each of the L. sakei sub-groups.
Deposition of Iridium Thin Films Using New IrI CVD Precursors (2002)

The syntheses of three volatile IrI cyclooctadiene precursors is described. The anionic ligand was carefully selected to produce a structure (see Figure) with physical properties suitable for CVD requirements. Films grown using oxygen as carrier gas produced iridium thin films with a purity higher than 98 % and a measured resistivity in the range of 8.4 to 10.2 μΩ cm.
transkingdom RNA Interference (tkRNAi): A Novel Method to Induce Therapeutic Gene Silencing (2009)

RNA interference is a phenomenon in which specific, endogenous genes are silenced by mRNA degradation. This technology is highly regarded as a potential therapeutic due to its high efficacy and low toxicity. However, the difficulty of delivering RNAi to target cells has impeded the development of RNAi-based therapies. One method to overcome this barrier is the use of a nonpathogenic bacteria vector, Escherichia coli, to deliver RNAi to target cells with high efficacy. In transkingdom interference RNAi (tkRNAi) delivery, E. coli were engineered to transcribe short RNA (shRNA) from a plasmid (TRIP) containing the invasin gene Inv and the listeriolysin O gene Hly. tkRNAi is successful in eliciting efficient gene silencing in vitro and in vivo.
Material for Making Resilient Light Pipes to be Mounted Without Silicon Grease (1964)

For a special neutron scintillation counter a light pipe material was required which could replace Plexiglas or Lucite. This material had to be elastic in order to make a good fit between a scintillation crystal and photomultiplier even when mechanical dimensions (distance, parallelism) were somewhat undefined. Furthermore, the use of silicon grease for making an optical seal was to be avoided. Silicoloid 201, an embedding compound for electronic components and circuits, fulfills these requirements. It has a refractive index of 1.408 and a reasonable transmission for scintillation light wavelengths. In addition, it is easy to mold into any shape and it adheres well to glass, forming stable but removable seals without grease.
Efficient graphical models for processing images (2004)

Graphical models are powerful tools for processing images. However, the large dimensionality of even local image data poses a difficulty. Representing the range of possible graphical model node variables with discrete states leads to an overwhelmingly large number of states for the model, often making both exact and approximate inference computationally intractable. We propose a representation that allows a small number of discrete states to represent the large number of possible image values at each pixel or local image patch. Each node in the graph represents the best regression function, chosen from a set of candidate functions, for estimating the unobserved image pixels from the observed samples. This permits a small number of discrete states to summarize the range of possible image values at each point in the image. Belief propagation is then used to find the best regressor to use at each point. To demonstrate the usefulness of this technique, we apply it to two problems: super-resolution and color demosaicing. In both cases, we find our method compares well against other techniques for these problems.
Potential therapeutic applications of oblimersen in CLL. (2004)

Bcl-2 protein is upregulated in a wide variety of lymphoid malignancies, including chronic lymphocytic leukemia (CLL). The protein is thought to be responsible for maintaining the viability of malignant lymphoid cells and may contribute to chemotherapy and radiotherapy resistance. Previous studies have shown that reduction of bcl-2 expression by antisense therapy sensitizes cells to chemotherapy-induced apoptosis. In vitro, the Bcl-2 antisense drug oblimersen sodium (Genasense, previously known as G3139) enhances the apoptotic response in CLL cells to fludarabine (Fludara), corticosteroids, alemtuzumab (Campath), and rituximab (Rituxan). A phase I trial in patients with refractory/relapsed CLL showed that patients with CLL were more sensitive to oblimersen than patients with solid tumors. The maximum tolerated oblimersen dose was 3 mg/kg/d, and the most common dose-limiting reaction was hypotension, frequently in association with high spiking fever. In this study, oblimersen displayed limited single-agent activity, including tumor lysis syndrome, transient decreases in circulating CLL cells, and reduction of splenomegaly and size of lymph nodes. Major responses were observed in 9% of patients. Subsequently, a phase III trial evaluating fludarabine and cyclophosphamide with or without oblimersen (3 mg/kg/d for 7 days) was initiated in patients with relapsed or refractory CLL. This trial recently completed accrual of 241 patients.
Efficient Multicast Video Streaming for IPTV Service over WLAN Using CC-FEC (2008)

With rapidly growing IPTV market and IPTV standardization activity, multicasting starts to gain a lot of attention again. The use of multicasting conserves the bandwidth of a network and this becomes especially important with wireless channels with limited throughput. But, multicasting over wireless channel is facing many challenges. In this paper, we discuss the challenges for the multicast streaming to provide IPTV service over WLAN and present system architecture to model the wireless IPTV service environment. And we apply a novel CC-FEC (Cross- correlated Forwarding Error Correction) scheme to the model and analyze the efficiency of the scheme.
Altered patterns of migration of cytokine‐producing T lymphocytes in skin‐grafted naive or immune mice following <i>in vivo</i> administration of anti‐VCAM‐1 or ‐ICAM‐1 (1996)

Naive or preimmunized (to B10.BR or BALB.k) C3H/HeJ mice received skin grafts from multiple minor histoincompatible B10.BR or BALB.k mice following antigen-specific portal venous (p.v.) pretransplant transfusion, a protocol known to produce prolongation of graft survival in naive animals. In addition, groups of mice received intravenous (i.v.) infusion following transplantation with a mixture of monoclonal antibodies (mAb) to vascular adhesion molecule-1L: very late activation antigen-4 (VCAM-1:VLA-4) or intracellular adhesion molecule-1:lymphocyte function-associated antigen-3 (ICAM-1:LFA-1). Cells were harvested from different tissues of the grafted mice at various times post grafting. RNA was extracted and analysed, using polymerase chain reaction, for expression of different cytokines potentially involved in the regulation of graft rejection [interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumour necrosis factor-alpha, interferon-gamma and transforming growth factor-beta]. In addition, using limiting dilution analysis, we investigated the frequency of allo-specific and third-party reactive cells producing IL-2 and IL-4 in vitro in different tissues of grafted mice following these treatments. The mAb treatment protocol which produced optimum increases in graft survival in naive versus immune mice was different, with anti-LFA-1:ICAM-1 superior for naive mice compared with anti-VLA-4:VCAM-1, and vice versa for immune animals. However, in each case, increased survival was associated with increases local to the graft in the frequency of occurrence of antigen-specific type-2 cytokine-producing cells.
Separation of Semiconducting Single‐Walled Carbon Nanotubes by Using a Long‐Alkyl‐Chain Benzenediazonium Compound (2006)

We designed and synthesized 4-dodecyloxybenzenediazonium tetrafluoroborate (1), which preferentially reacts with metallic single-walled carbon nanotubes (SWNTs) by kinetic control. We first determined the suitable experimental conditions for the preferential reaction of 1 with individually dissolved SWNTs by monitoring the decrease in absorbance for the metallic SWNT in the range of 400-650 nm in the absorption spectrum of the SWNTs. The reacted SWNTs were thoroughly rinsed with THF to obtain THF-insoluble SWNTs. The Raman spectrum of the THF-insoluble SWNTs showed a strong peak near 180 cm(-1), which corresponds to a semiconducting breathing band. The metallic breathing bands (approximately 220 cm(-1)) and Breit-Wingner-Fano (BWF) modes (1520 cm(-1)) corresponding to the metallic SWNTs were much weaker than those of the pristine SWNTs. We also confirmed that metallic peaks in the range of 400-650 nm in the absorption spectrum of THF-insoluble SWNTs that were individually dissolved in an aqueous micelle of sodium cholate were almost nondetectable. All the results indicate that the THF-insoluble SWNTs are semiconducting.
On the efficiency of automatically generated accelerators for reconfigurable active SSDs (2014)

Modern high level synthesis (HLS) tools generate Register Transfer Language (RTL) from designs specified in high level languages such as C. By raising the design abstraction level while still promising competitive performance, HLS tools can greatly reduce design effort and time. Contemporary HLS tools can support most manual hardware design optimization techniques such as pipelining and fine-grain data communication. In this paper we study the effectiveness of the Xilinx Vivado HLS tool in generating hardware accelerators for map/reduce kernels, and we compare their performance and logic resource utilization to accelerators generated from hand-coded RTL. Our experimental results show that for most cases, the Vivado tool produces accelerators whose performance is within 9% of handcoded RTL, and whose logic resource utilization is significantly lower.
Type II photoreactions of phenyl ketones. Competitive charge transfer in .alpha.-, .gamma.-, and .delta.-dialkylamino ketones (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTType II photoreactions of phenyl ketones. Competitive charge transfer in .alpha.-, .gamma.-, and .delta.-dialkylamino ketonesPeter J. Wagner, Allen E. Kemppainen, and Thomas JellinekCite this: J. Am. Chem. Soc. 1972, 94, 21, 7512–7519Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://doi.org/10.1021/ja00776a038RIGHTS & PERMISSIONSArticle Views114Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (924 KB) Get e-Alerts Get e-Alerts
Von Willebrand Factor Antigen Is Less Sensitive than Ristocetin Cofactor for the Diagnosis of Type I von Willebrand Disease -Results Based on an Epidemiological Investigation (1990)

Recently, in an epidemiological investigation involving 1,218 children aged 11-14, we demonstrated that the prevalence of von Willebrand's disease, based on a low ristocetin cofactor activity (RiCof) in children with a personal and/or family history of hemorrhage, was at least 1% (Blood 1987; 69: 454). All the diagnosed cases had multimeric patterns typical of type I von Willebrand's disease (vWd). Since standardization of RiCof is difficult and the test is not easily performed in a clinical laboratory, we measured von Willebrand factor antigen (vWf:Ag) in all available unthawed plasma samples of previously investigated children by ELISA, to assess the relative sensitivity of this more simple test for diagnosing vWd. Separate normal ranges were calculated by non-parametric methods for 0 and non-0 subjects, and for children and adults, since values were higher in non-0 subjects and in children. Taking into account the 90% confidence interval around the lower limit of the normal range, 7 (50%) of the 14 cases diagnosed by RiCof were detected by vWf:Ag. Furthermore, two new cases would have been diagnosed by vWf:Ag, leading to a relative Ag/RiCof global sensitivity of 64%. A similar figure was obtained when the two tests were compared in the group of relatives of the affected children. In conclusion, measurement of vWf:Ag seems to be definitely less sensitive than the RiCof assay for detecting patients with vWd, even in type I patients, and RiCof remains the test of choice for screening for vWd in hemorrhagic patients.
A meta-analysis of overall survival data from three randomized trials of bevacizumab (BV) and first-line chemotherapy as treatment for patients with metastatic breast cancer (MBC). (2010)

1005 Background: E2100, AVADO, and RIBBON-1, three randomized trials in patients with MBC evaluating BV plus first-line chemotherapy regimens (taxane-, anthracycline-, or capecitabine-based), each demonstrated improvement in the primary endpoint of progression-free survival (PFS). Although the trials were not designed to show an overall survival (OS) benefit, it was a secondary endpoint in all trials. We present a meta-analysis of OS in 2,447 patients from these trials using complete survival data for each study. Methods: Kaplan—Meier methodology was used to estimate the median duration of PFS and OS. Stratified log-rank test was used to assess the difference in PFS and OS between treatment arms (control vs. BV+chemo). Stratified hazard ratio (HR) was estimated using the Cox regression model. Each individual study was included as a stratification factor in the stratified analysis. 1-year survival rate was compared using normal approximation method. All p-values were two-sided and tested at the type I error rate of 0.05. Results: 2,447 patients were included (1,008 control; 1,439 BV+chemo). Patient characteristics were well- balanced between the arms (overall median age, 56; hormone receptor-positive, 73%; prior adjuvant chemo, 62%; ≥3 metastatic sites, 40%). Duration of follow-up ranged from 29 (AVADO) to 36 (E2100) months. In the pooled analysis, median PFS improved from 6.7 to 9.2 mo (HR=0.64, p<0.0001) in the BV arms. Pooled results for OS showed no statistically significant difference between the arms (median OS control 26.4 mo, BV+chemo 26.7 mo; HR=0.97, (95% CI, 0.86–1.08, p=0.56). 1 yr survival rate was greater in the BV+chemo arms (control, 76.5%; BV+chemo, 81.6%, p=0.003). Results were consistent across key subgroups. Conclusions: Results from the exploratory analysis of the pooled PFS data show that BV, when combined with first-line chemotherapy (taxane-, anthracycline-, or capecitabine-based regimens), results in clinically meaningful and statistically significant improvements in PFS. Though no statistically significant difference in median OS was seen, the pooled OS data from these trials suggest an early benefit at 1 year. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Genentech, NICRC CCOP-NCI Genentech, Roche Roche Genentech, Roche Genentech