gebhart/patrepeval huggingface dataset:
Effect of unilateral partial cochlear lesions in adult cats on the representation of lesioned and unlesioned cochleas in primary auditory cortex (1993)

We examined the effect of unilateral restricted cochlear lesions in adult cats on the topographic representations ("maps") of the lesioned and unlesioned cochleas in the primary auditory cortex (AI) contralateral to the lesioned cochlea. Frequency (tonotopic) maps were derived by conventional multineuron mapping procedures in anesthetized animals. In confirmation of a study in adult guinea pigs (Robertson and Irvine [1989] J. Comp. Neurol. 282:456-471), we found that 2-11 months after the unilateral cochlear lesion the map of the lesioned cochlea in the contralateral AI was altered so that the AI region in which frequencies with lesion-induced elevations in cochlear neural sensitivity would have been represented was occupied by an enlarged representation of lesion-edge frequencies (i.e., frequencies adjacent to those with elevated cochlear neural sensitivity). Along the tonotopic axis of AI the total representation of lesion-edge frequencies could extend up to approximately 2.6 mm rostal to the area of normal representation of these frequencies. There was no topographic order within this enlarged representation. Examination of threshold sensitivity at the characteristic frequency (CF, frequency to which the neurons were most sensitive) in the reorganized regions of the map of the lesioned cochlea established that the changes in the map reflected a plastic reorganization rather than simply reflecting the residue of prelesion input. In contrast to the change in the map of the lesioned contralateral cochlea, the map of the unlesioned ipsilateral cochlea did not differ from those in normal animals. Thus, in contrast to the normal very good congruency between ipsilateral and contralateral AI maps, in the lesioned animals ipsilateral and contralateral maps differed in the region of AI in which there had been a reorganization of the map of the lesioned cochlea. Outside the region of contralateral map reorganization, ipsilateral and contralateral AI maps remained congruent within normal limits. The difference between the two maps in the region of contralateral map reorganization suggested, in light of the physiology of binaural interactions in the auditory pathway, that the cortical reorganization reflected subcortical changes. Finally, response properties of neuronal clusters within the reorganized map of the lesioned cochlea were compared to normative data with respect to threshold sensitivity at CF, the size of frequency "response areas," and response latencies. In the majority of cases, CF thresholds were similar to normative data. The frequency "response areas" were slightly less sharply tuned than normal, but not significantly. Response latencies were significantly shorter than normal in three animals and significantly longer in one animal.
Rapid Entire Body Assessment (2004)

Rapid entire body assessment (REBA) (Hignett and McAtamney, 2000) was developed to assess the type of unpredictable working postures found in health-care and other service industries. Data are collected about the body posture, forces used, type of movement or action, repetition, and coupling. A final REBA score is generated to give an indication of the level of risk and urgency with which action should be taken.
Layer-By-Layer Controlled Digital Etching by Means of an Electron-Beam-Excited Plasma System (1990)

Characteristics o digital etching using an electron-beam-excited plasma system in GaAs are reported. In digital etching, etchant gas pulses and Ar ions are sequentially impinged onto the substrate surface to be etched. When the energy of Ar ion is -17 eV, etch rates which correspond to the 0.5 monolayer (ML) per cycle of GaAs (0.142 nm) are obtained between 0.3 and 0.5 seconds of Cl 2 feed time by using Cl radicals as etchants. With these etching parameters, a rectangular cross-sectional etch profile with smooth surface is obtained. Damages induced in digital etching was characterized by current-voltage measurement of the diode fabricated after the etching.
Tetrahydropentalene (1987)

Abstract Das aus Cyclooctatetraen zugängliche 1,2‐Dihydropentalen ( 9 ) kann mit LiAlH 4 zu 1,2,3,4‐Tetrahydropentalen ( 2 ) und 1,2,3,5‐Tetrahydropentalen ( 3 ) reduziert werden. Zur präparativen Herstellung arbeitet man für 2 bei kinetischer Kontrolle, für 3 bei thermodynamischer Kontrolle. Die vergleichbare Addition von tert ‐Butyllithium führt zu den substituierten Tetrahydropentalenen 17 – 19 . Zur Strukturaufklärung und zur Untersuchung der Isomerisierungsgleichgewichte dienen Deuterierungen und ausführliche 1 H‐ bzw. 13 C‐NMR‐spektroskopische Messungen.
Schema-guided wrapper maintenance for web-data extraction (2003)

Extracting data from Web pages using wrappers is a fundamental problem arising in a large variety of applications of vast practical interests. There are two main issues relevant to Web-data extraction, namely wrapper generation and wrapper maintenance. In this paper, we propose a novel schema-guided approach to the problem of automatic wrapper maintenance. It is based on the observation that despite various page changes, many important features of the pages are preserved, such as syntactic patterns, annotations, and hyperlinks of the extracted data items. Our approach uses these preserved features to identify the locations of the desired values in the changed pages, and repair wrappers correspondingly by inducing semantic blocks from the HTML tree. Our intensive experiments on real Web sites show that the proposed approach can effectively maintain wrappers to extract desired data with high accuracies.
Repetitive on-demand drug release by magnetic heating of iron oxide containing polymeric implants (2011)

Drug release from a polymeric matrix has been externally triggered using an alternating magnetic field in order to develop an on-demand drug delivery implant. Superparamagnetic iron oxide nanoparticles have been distributed in a poly(methyl methacrylate) core, coated with a thermoresponsive layer of poly(butyl methacrylate-stat-methyl methacrylate) containing ibuprofen as a model drug. The release rate of ibuprofen reversibly increased, up to 25-fold, upon exposure to the magnetic field and was found to increase with higher iron oxide loading. Finally, magnetically triggered on-demand drug release was demonstrated under physiologically relevant conditions, namely 37 °C in PBS buffer with high ibuprofen content in the implant and only 15 minutes triggering time.
Efficient communication protocols for underwater acoustic sensor networks (2007)

Underwater sensor networks find applications in oceanographic data collection, pollution monitoring, offshore exploration, disaster prevention, assisted navigation, tactical surveillance, and mine reconnaissance. The enabling technology for these applications is acoustic wireless networking. UnderWater Acoustic Sensor Networks (UW-ASNs) consist of sensors and Autonomous Underwater Vehicles (AUVs) deployed to perform collaborative monitoring tasks. The objective of this research is to explore fundamental key aspects of underwater acoustic communications, propose communication architectures for UW-ASNs, and develop efficient sensor communication protocols tailored for the underwater environment. Specifically, different deployment strategies for UW-ASNs are studied, and statistical deployment analysis for different architectures is provided. Moreover, a model characterizing the underwater acoustic channel utilization efficiency is introduced. The model allows setting the optimal packet size for underwater communications. Two distributed routing algorithms are proposed for delay-insensitive and delay-sensitive applications. The proposed routing solutions allow each node to select its next hop, with the objective of minimizing the energy consumption taking the different application requirements into account. In addition, a resilient routing solution to guarantee survivability of the network to node and link failures in long-term monitoring missions is developed. Moreover, a distributed Medium Access Control (MAC) protocol for UW-ASNs is proposed. It is a transmitter-based code division multiple access scheme that incorporates a novel closed-loop distributed algorithm to set the optimal transmit power and code length. It aims at achieving high network throughput, low channel access delay, and low energy consumption. Finally, an efficient cross-layer communication solution tailored for multimedia traffic (i.e., video and audio streams, still images, and scalar sensor data) is introduced.
An automated model based testing approach for platform games (2015)

Game development has recently gained a lot of momentum and is now a major software development industry. Platform games are being revived with both their 2D and 3D versions being developed. A major challenge faced by the industry is a lack of automated system-level approaches for game testing. Currently in most game development organizations, games are tested manually or using semi-automated techniques. Such testing techniques do not scale to the industry requirements where more systematic and repeatable approaches are required. In this paper we propose a model-based testing approach for automated black box functional testing of platform games. The paper provides a detailed modeling methodology to support automated system-level game testing. As part of the methodology, we provide guidelines for modeling the platform games for testing using our proposed game test modeling profile. We use domain modeling for representing the game structure and UML state machines for behavioral modeling. We present the details related to automated test case generation, execution, and oracle generation. We demonstrate our model-based testing approach by applying it on two cases studies, a widely referenced and open source implementation of Mario brothers game and an industrial case study of an endless runner game. The proposed approach was able to identify major faults in the open source game implementation. Our results showed that the proposed approach is practical and can be applied successfully on industrial games.
Studies on Polynucleotides (1972)

The transcription of three short synthetic bihelical DNA's of defined sequence was studied with RNA polymerase of Escherichia coli. DNA-I is a completely base-paired duplex, DNA-II contains a single-stranded portion with a 3′-hydroxyl end group while DNA-III contains a protruding single-stranded region with a 5′-hydroxyl end group. All the three DNA's were transcribed by the polymerase but the RNA formed was heterogeneous. Initiation occurred at multiple sites with purine nucleoside triphosphates and there was evidence that both strands were transcribed. A part of the RNA formed had higher molecular weight than the template strands. Attempts to control initiation by using a complementary ribo-oligonucleotide primer and also rifampicin were only partially successful.
Future applications and the Aeronautical Telecommunication Network (2002)

The Aeronautical Telecommunication Network (ATN) is designed to carry air traffic control (ATC) communications. The ATN is based on the Open Systems Interconnect (OSI) architecture which affords flexibility for data communications between end systems. The ATN was created by the International Civil Aviation Organization (ICAO) and, when implemented, will provide basic point-to-point communications with performance appropriate for ATC applications. Applications which provide digital equivalents of current voice services are the initial application targets of the ATN. It is becoming clear, however, that future air traffic management applications will not only rely increasingly on data communications but will require new or modified ATN capabilities. This paper will review the basic architecture of the ATN, examine the communications requirements of some current and future air traffic management applications, and suggest areas for expansion of ATN capabilities.
Augmented reality technology in the manufacturing industry: A review of the last decade (2018)

The aim of this article is to analyze and review the scientific literature relating to the application of Augmented Reality (AR) technology in industry. AR technology is becoming increasingly diffuse, due to the ease of application development and the widespread use of hardware devices (mainly smartphones and tablets) able to support its adoption. Today, a growing number of applications based on AR solutions are being developed for industrial purposes. Although these applications are often little more than experimental prototypes, AR technology is proving highly flexible and is showing great potential in numerous areas (e.g., maintenance, training/learning, assembly or product design) and in industrial sectors (e.g., the automotive, aircraft or manufacturing industries). It is expected that AR systems will become even more widespread in the near future.The purpose of this review is to classify the literature on AR published from 2006 to early 2017, to identify the main areas and sectors where AR is currently deployed, describe the technological solutions adopted, as well as the main benefits achievable with this kind of technology.
Modulation of Endothelial Cell K <sub>Ca</sub> 3.1 Channels During Endothelium-Derived Hyperpolarizing Factor Signaling in Mesenteric Resistance Arteries (2008)

Arterial hyperpolarization to acetylcholine (ACh) reflects coactivation of K(Ca)3.1 (IK(Ca)) channels and K(Ca)2.3 (SK(Ca)) channels in the endothelium that transfers through myoendothelial gap junctions and diffusible factor(s) to affect smooth muscle relaxation (endothelium-derived hyperpolarizing factor [EDHF] response). However, ACh can differentially activate K(Ca)3.1 and K(Ca)2.3 channels, and we investigated the mechanisms responsible in rat mesenteric arteries. K(Ca)3.1 channel input to EDHF hyperpolarization was enhanced by reducing external [Ca(2+)](o) but blocked either with forskolin to activate protein kinase A or by limiting smooth muscle [Ca(2+)](i) increases stimulated by phenylephrine depolarization. Imaging [Ca(2+)](i) within the endothelial cell projections forming myoendothelial gap junctions revealed increases in cytoplasmic [Ca(2+)](i) during endothelial stimulation with ACh that were unaffected by simultaneous increases in muscle [Ca(2+)](i) evoked by phenylephrine. If gap junctions were uncoupled, K(Ca)3.1 channels became the predominant input to EDHF hyperpolarization, and relaxation was inhibited with ouabain, implicating a crucial link through Na(+)/K(+)-ATPase. There was no evidence for an equivalent link through K(Ca)2.3 channels nor between these channels and the putative EDHF pathway involving natriuretic peptide receptor-C. Reconstruction of confocal z-stack images from pressurized arteries revealed K(Ca)2.3 immunostain at endothelial cell borders, including endothelial cell projections, whereas K(Ca)3.1 channels and Na(+)/K(+)-ATPase alpha(2)/alpha(3) subunits were highly concentrated in endothelial cell projections and adjacent to myoendothelial gap junctions. Thus, extracellular [Ca(2+)](o) appears to modify K(Ca)3.1 channel activity through a protein kinase A-dependent mechanism independent of changes in endothelial [Ca(2+)](i). The resulting hyperpolarization links to arterial relaxation largely through Na(+)/K(+)-ATPase, possibly reflecting K(+) acting as an EDHF. In contrast, K(Ca)2.3 hyperpolarization appears mainly to affect relaxation through myoendothelial gap junctions. Overall, these data suggest that K(+) and myoendothelial coupling evoke EDHF-mediated relaxation through distinct, definable pathways.
Murabutide Revisited: A Review of its Pleiotropic Biological Effects (2013)

Despite the great efforts put into their development, the list of clinically approved immunological adjuvants is still very short. Evolution of the knowledge of the immune system has enabled for rational design of novel adjuvants and has led to the conclusion that more than one type of adjuvant will be required. Derivatives of muramyl dipeptide (MDP), the minimal immunomodulatory structure of bacterial cell wall peptidoglycan, have gained considerable attention in the past decades, because of their potent adjuvant effects. Murabutide is a safe derivative of MDP, which interacts with cells of the immune system, both innate and adaptive, and exerts its effect through activation of Nod2. The transcriptional response of murabutide-stimulated macrophages revealed enhanced expression of genes coding for various proteins such as immune mediators and their receptors, transcription factors and kinases, ion channels/transporters and proteins involved in cell metabolic activity, thus reflecting a broad spectrum of biological effects. In addition to its well recognized adjuvant effect, murabutide has also been shown to enhance the host's resistance against microbial infections, nonspecific resistance against tumors and the induction of cytokines and chemokines implicated in enhancing the immune response and hematopoesis. This article provides an insight into the mechanism of action of murabutide and its interactions with the cells of the immune system in vitro and in vivo. On account of its numerous biological effects, murabutide has been the subject of several clinical studies. Many of these have confirmed its potential to synergize with cytokines of therapeutic interest in potentiating the tumoricidal activity of macrophages or targeting chronic viral diseases, as well as reducing the cytokine dosage needed to achieve a therapeutic effect. This review covers the findings of all relevant studies and focuses on the role of murabutide and its potential in the treatment of several microbial diseases.
17β‐estradiol upregulates GREB1 and accelerates ovarian tumor progression <i>in vivo</i> (2014)

Exogenous 17β-estradiol (E2) accelerates the progression of ovarian cancer in the transgenic tgCAG-LS-TAg mouse model of the disease. We hypothesized that E2 has direct effects on ovarian cancer cells and this study was designed to determine the molecular mechanisms by which E2 accelerates ovarian tumor progression. Mouse ovarian cancer ascites (MAS) cell lines were derived from tgCAG-LS-TAg mice. Following intraperitoneal engraftment of two MAS cell lines, MASC1 and MASE2, into SCID mice, exogenous E2 significantly decreased the survival time and increased the tumor burden. Microarray analysis performed on MASE2-derived tumors treated with E2 or placebo showed that E2 treatment caused the upregulation of 197 genes and the downregulation of 55 genes. The expression of gene regulated by estrogen in breast cancer 1 (Greb1) was upregulated in mouse tumors treated with E2 and was overexpressed in human ovarian cancers relative to human ovarian surface epithelium, suggesting a role for GREB1 in human ovarian tumor progression. RNA interference-mediated knockdown of GREB1 in MASE2 cells decreased their proliferation rate in vitro and increased survival time in mice engrafted with the cells. These results emphasize the importance of E2 in ovarian tumor progression and identify Greb1 as a novel gene target for therapeutic intervention.
Advanced functional safety mechanisms for embedded memories and IPs in automotive SoCs (2017)

Given the fast growing complexity and miniaturization of automotive SoCs, this paper presents functional safety challenges and related solutions for such SoCs. The paper is based on ISO 26262 standard and shows experimental results on a SoC example to demonstrate the advantages of the proposed solutions.
A CAC scheme based on real-time cell loss estimation for ATM multiplexers (2000)

For the superposition of on/off sources, we propose a real-time computable two-state Markov modulated Poisson process [MMPP(2)] modeling method characterizing the aggregate cell arrival rate and the variance-time curve for cell counts. Numerical examples show that the proposed method yields a good estimation of the cell loss ratio (CLR) in asynchronous transfer mode (ATM) multiplexers. Then, we propose an approximation method for calculating the workload for the MMPP(2)/D/1 system. By considering the workload as an upper bound of CLR of ATM multiplexers, we propose a connection admission control (CAC) algorithm utilizing peak cell rate, sustainable cell rate, and maximum burst size as user traffic descriptors. Using the proposed CAC algorithm, an acceptance decision is made with computational complexities of less than 3000 floating point operations. It is also observed from numerical evaluations that the proposed CAC algorithm yields a high multiplexing gain, compared with other methods in the literature.
Effect of some nonyl derivatives and related compounds on germination of uredospores (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of some nonyl derivatives and related compounds on germination of uredosporesRichard C. French and Milton D. GallimoreCite this: J. Agric. Food Chem. 1971, 19, 5, 912–915Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1 May 1971https://pubs.acs.org/doi/10.1021/jf60177a058https://doi.org/10.1021/jf60177a058research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Retarding-Field Oscillators (1952)

Pendulum and velocity-variation types of oscillations in retarding-field oscillators are discussed. The processes of bunching, drifting, and working of the electrons are explained, and a comparison is made to a reflex klystron. Recent results obtained from retarding-field oscillators are given.
Wavelet Video Denoising with Regularized Multiresolution Motion Estimation (2006)

This paper develops a new approach to video denoising, in which motion estimation/compensation, temporal filtering, and spatial smoothing are all undertaken in the wavelet domain. The key to making this possible is the use of a shift-invariant, overcomplete wavelet transform, which allows motion between image frames to be manifested as an equivalent motion of coefficients in the wavelet domain. Our focus is on minimizing spatial blurring, restricting to temporal filtering when motion estimates are reliable, and spatially shrinking only insignificant coefficients when the motion is unreliable. Tests on standard video sequences show that our results yield comparable PSNR to the state of the art in the literature, but with considerably improved preservation of fine spatial details.