gebhart/patrepeval huggingface dataset:
Cryogenic surgery (1982)

Although the application of cold has been known as an effective means of relieving pain and for the treatment of trauma and inflammation since the time of the ancient Greeks it was not until about 1961 that controlled cryosurgery became an acceptable technique in medicine. Since then it has found increasing application in almost all branches of medical science. This review discusses the generally accepted qualitative and quantitative reasons for the cryodestruction of in vitro cells during freezing and thawing and its relation to in vivo tissue destruction. Because the lethal freeze-thaw cycle is critically dependent on the cooling and warming rates a fairly extensive discussion of the theoretical methods used to determine cell thermal history is included. A short description of the different types of cryosurgical equipment in general use today is included along with the methods which have been used to monitor the extent of the cryolesion. The various areas of clinical application of cryogenic surgery are described together with the authors' views for future developments in this field.
A Links-Nodes-Blobs Model for Conductive Polymer Composites (2001)

A Links-Nodes-Blobs (L-N-B) model, based on the fractal and percolation concepts, is used to study the electrically conductive mechanism of conductive filler loaded polymer composites. The change in the conductivity of polymer composites during the mixing process can be explained as the competition between the breakdown of filler aggregates and the diffusion of ingredients of matrix material and impurities onto the surface of the filler. The value of the fractal dimension μ, which is the exponent in the power-law relationship of the electrical conductivity σ = σ0·(ϕ – ϕc)μ, is calculated as 1.88. This value is close to the values obtained directly from experiments or from other simulations. The positive temperature coefficient (PTC) behavior in the conductivity of composite material is also explained by this model as the breakdown of the conductive filler network. If the thermo-expansion induced strain is greater than the apparent on-set strain εonset = mQ + 2 G/2d G·εb of the L-N-B model, a strong PTC effect would happen.
Bactericidal activity of human serum against Escherichia coli chi1776 (1980)

Escherichia coli chi1776 is a host strain providing the EK2 level of biological containment. Laboratories equipped to use this strain may be located near medical care facilities where patients prone to infection may be found. We have therefore documented the marked susceptibility of chi1776 to killing by human serum from normal as well as ill individuals.
The Use of Nystatin to Restore the Flow Properties ofTime-Expired Stored Erythrocytes (1987)

Human erythrocytes stored for more than 21 days in citrate phosphate dextrose with adenine (CPDA-1) exhibited a marked reduction in volume following incubation for 24 h at 37 °C in fresh autologous plasma. This incubation apparently mimics the effects of reinfusion of the stored cells in vivo. These shrunken stored cells have a decreased fllterability as measured by their increased transit times through a 5-µm diameter Nuclepore filter. The polyene antifungal agent nystatin was used to reinflate these shrunken cells with different concentrations of potassium ions. A concentration of 90 mM potassium chloride was found to reinflate the shrunken stored cells so that their mean cell volume, mean corpuscular haemoglobin concentration and average densities were the same as those of fresh cells. This reinflation also restored the fllterability of the shrunken stored cells so as to be similar to that of fresh cells.
ChemInform Abstract: COALCOHOLYSIS OF ORGANOSILAZANES AND ORGANOCYCLOSILAZAOXANES WITH ORGANOCHLOROSILANES AND ORGANOCHLOROSILOXANES (1976)

Abstract Die Aktivität der Si‐N‐Bindung in Organosilazanen bei der Umsetzung mit Alkoholen und Glykolen wird durch die Gegenwart von Organochlorsilanen oder Organochlorsiloxanen gesteigert.
Measurement of total lactate dehydrogenase activity. (1985)

Lactate dehydrogenase (LD: EC 1.1.1.27) is the most important clinically of several dehydrogenases occurring in human serum. Lactate dehydrogenase is cytoplasmic in its cellular location and in any one tissue is composed of one or two of five possible isoenzymes. While many of its clinical applications involve quantification of one or more specific serum isoenzymes, an estimate of total LD is required usually. Lactate dehydrogenase catalyzes the reversible reaction: L-lactate + NAD+ in equilibrium pyruvate + NADH. The bidirectional reaction is monitored spectrophotometrically by measuring either the increase in NADH at 340 nm produced in the lactate-to-pyruvate reaction (L----P) or by the decrease in NADH at 340 nm produced in the pyruvate-to-lactate (P----L) reaction. Kinetic assay systems for the measurement of the reaction system in both directions are comprehensively reviewed as well as the standardization efforts proposed to date.
Modulation of phagocytic function in murine peritoneal macrophages by bombesin, gastrin-releasing peptide and neuromedin C. (1991)

Bombesin, as well as the two mammalian bombesin-like peptides gastrin-releasing peptide and neuromedin C, have been shown in this study to stimulate in vitro all steps of the phagocytic process in murine peritoneal macrophages: adherence to substrate, chemotaxis, ingestion of cells (Candida albicans) and inert particles (latex beads), and production of superoxide anion as measured by nitroblue tetrazolium reduction. A dose-response relationship was observed, with maximal stimulation of phagocytic process between 10(-12)M and 10(-9)M. Gastrin-releasing peptide (GRP) and neuromedin C caused a higher activation of adherence, chemotaxis and ingestion of C. albicans than bombesin. The three neuropeptides induced in murine macrophages a significant, but transient, increase of inositol 1,4,5-trisphosphate (IP3) levels at 60 seconds. On the contrary, these neuropeptides produced a rapid, transient and significant decrease of cAMP at 30 seconds. These results suggest that there are close relations between IP3 and cAMP messenger systems and the phagocytic process in murine peritoneal macrophages when these cells are incubated in the presence of bombesin, GRP or neuromedin C.
Ethyleninsertion durch lösliche Ziegler‐Katalysatoren. Direkter Einblick durch reagierendes Ethylen‐<sup>13</sup>C mit Hilfe der <sup>13</sup>C‐NMR‐Spektroskopie (1981)

Abstract Elementarprozesse löslicher Ziegler‐Katalysatoren vom Typ Cp 2 TiRCl/AlEt n Cl m wurden mit Hilfe der 13 C‐NMR‐Spektroskopie studiert, die sich dabei durch Einsatz von mit 13 C angereichertem Ethylen als eine Möglichkeit erwiesen hat, direkten detaillierten Einblick in das reagierende und polymerisierende System zu gewinnen. Danach ist durch die Komplexbildung die Elektronendichte am Titan erniedrigt. Es erfolgt keine spektroskopisch nachweisbare Vorkoordination des Monomeren. Das System Cp 2 TiEtCl/AlEtCl 2 ist bereits bei 200 K polymerisationsaktiv. Die Insertion erfolgt eindeutig in der Titan‐Kohlenstoffbindung. Das System Cp 2 TiEtCl/AlEt 3 ist—auch wenn noch keine Reduktion stattgefunden hat—nicht polymerisationsaktiv.
Phosphorylation of Threonine Residue 276 Is Required for Acute Regulation of Serotonin Transporter by Cyclic GMP (2007)

Cellular protein kinases, phosphatases, and other serotonin transporter (SERT) interacting proteins participate in several signaling mechanisms regulating SERT activity. The molecular mechanisms of protein kinase G (PKG)-mediated SERT regulation and the site of transporter phosphorylation were investigated. Treatment of rat midbrain synaptosomes with 8-bromo-cGMP increased SERT activity, and the increase was selectively blocked by PKG inhibitors. The V(max) value for serotonin (5-HT) transport increased following cGMP treatment. However, surface biotinylation studies showed no change in SERT surface abundance following PKG activation. (32)P metabolic labeling experiments showed increased SERT phosphorylation in the presence of cGMP that was abolished by selectively inhibiting PKG. Phosphoamino acid analysis revealed that cGMP-stimulated native SERT phosphorylation occurred only on threonine residues. When added to CHO-1 cells expressing SERT, 8-bromo-cGMP stimulated 5-HT transport and SERT phosphorylation. Mutation of SERT threonine 276 to alanine completely abolished cGMP-mediated stimulation of 5-HT transport and SERT phosphorylation. Although the T276A mutation had no significant effect on 5-HT transport or SERT protein expression, mutation to aspartate (T276D) increased the level of 5-HT uptake to that of cGMP-stimulated 5-HT uptake in wild-type SERT-expressing cells and was no longer sensitive to cGMP. These findings provide the first identification of a phosphorylation site in SERT and demonstrate that phosphorylation of Thr-276 is required for cGMP-mediated SERT regulation. They also constitute the first evidence that in the central nervous system PKG activation stimulates endogenous SERT activity by a trafficking-independent mechanism.
Consideration on Current and Coil Block Placements With Good Homogeneity for MRI Magnets Using Truncated SVD (2012)

This paper describes a new method to determine the current and coil block placements with good homogeneity for magnetic resonance imaging (MRI) magnets, and discusses the relationships between the placements and homogeneity, using regularization of the truncated singular value decomposition (SVD). In the first step, the main coil (MC) is modeled as filament loop currents (FLCs) on a solenoid and the shield coil (SC) is modeled by coil blocks. The FLCs are determined so as to get a homogeneous magnetic field using a superposition of eigenmodes obtained by the SVD. In the second step, the FLCs are replaced by MC blocks. The findings are as follows. 1) The obtained FLC distribution in the axial direction has several peaks, which can be suitably replaced by MC blocks and the number of the peaks is equal to the number of MC blocks. 2) There is an optimum length to minimize the absolutely summed current and the 1542-mm length is the optimum for a 525-mm radius with six MC blocks. 3) A one-eigenmode (one MC block) increase or decrease changes the length by +87 or -105 mm, respectively. 4) Six MC blocks can provide 1-ppm peak-to-peak homogeneity in the 400-mm diameter spherical imaging volume and this is adequate for MRI magnets.
Isolation and characterization of the SPT2 gene, a negative regulator of Ty-controlled yeast gene expression. (1985)

The his4-917 mutation of Saccharomyces cerevisiae results from the insertion of the Ty element Ty917 into the regulatory region of the HIS4 gene and renders the cell His-. The hist4-912 delta mutant, which carries a solo delta in the 5'-noncoding region of HIS4, is His+ at 37 degrees C but His- at 23 degrees C. Both these mutations interfere with HIS4 expression at the transcriptional level. The His- phenotype of both insertion mutations is suppressed by mutations at the SPT2 locus. The product of the wild-type SPT2 gene apparently represses HIS4 transcription in these mutant strains; this repression is relieved when the SPT2 gene is destroyed by mutation. The repression of transcription by SPT2 presumably results from an interaction between the SPT2+ gene product and Ty or delta sequences. In this paper, we report the cloning and DNA sequence analysis of the wild-type SPT2 gene and show that the gene is capable of encoding a protein of 333 amino acids in length. In addition, we show that a dominant mutation of the SPT2 gene results from the generation of an ochre codon which is presumed to lead to a shortened SPT2 gene product.
Navier-Stokes Computations of Cavity Aeroacoustics with Suppression Devices (1994)

Effectiveness of two devices to suppress the cavity acoustics was computationally investigated. Two dimensional, computational simulations were performed for the transonic, turbulent flows past a cavity, which was first equipped with a rear face ramp and then with a spoiler. The Reynolds-averaged, unsteady, compressible, full Navier-Stokes equations were solved time accurately by a second-order accurate, implicit, upwind, finite-volume method. The effect of turbulence was included through the Baldwin-Lomax model with modifications for the multiple-wall effects and for the highly vortical flow with a shear layer. The results included instantaneous and time-averaged flow properties, and time-series analyses of the pressure inside the cavity, which compared favorably with the available experimental data. These results were also contrasted with the computed aeroacoustics of the same cavity (length-to-depth ratio of 4.5), but without a device, to demonstrate the suppression effectiveness.
Submicrometer Superconducting YBa <sub>2</sub> Cu <sub>3</sub> O <sub>6+x</sub> Particles Made by a Low-Temperature Synthetic Route (1989)

Evidence suggests that superconducting, orthorhombic YBa(2)Cu(3)O(6+x)+ (x greater, similar 0.5) is always produced by oxidation of the oxygen-deficient, tetragonal form (x less, similar 0.5) of this phase (commonly referred to as 123). A synthetic route whereby solution-derived, carbon-free precursors are decomposed at 650 degrees to 700 degrees C in inert atmosphere to yield tetragonal 123 is now available. Appropriate precursors include hydrated oxides derived from the hydrolysis of organometallic solutions and aqueous solution-derived hyponitrites. Subsequent oxidation of the tetragonal phase at 400 degrees C results in submicrometer particles of orthorhombic 123. Superconductivity (T(c) onset approximately 87 K) has been confirmed in these materials by both Meissner effect and specific-heat measurements.
Effect of EHDP on fracture healing in dogs (1985)

Ethane-1-hydroxy-1,1-diphosphonate (EHDP) was administered subcutaneously to mature beagle dogs at dose levels of 0.1, 0.5, and 5.0 mg/kg/day for a 20 week period to determine the drug's effects on fracture healing. Uniform, transverse fractures of the midshaft radius were created in one limb and treated by external splintage. Drug-induced effects on fracture healing were monitored radiographically, histologically, and histomorphometrically; mechanical properties of the healing bones were determined in 4-point bending tests. At a dose of 0.1 mg/kg/day, ultimate load at failure and flexural rigidity of the fractured limbs equaled or exceeded that of saline control animals, and radiographic healing was normal. At a dose of 0.5 mg/kg/day ultimate load at failure and flexural rigidity of the fractured limbs proved inferior to saline control values, and radiographic healing appeared delayed. At a dosage of 5.0 mg/kg/day, there was obvious radiographic nonunion, and the callus of fractured radii had little inherent flexural rigidity or strength. Histomorphometrically, no differences were noted between control animals and the 0.1 or 0.5 mg/kg/day groups; however, mineralization activity appeared totally disrupted at the higher dosage level (5.0 mg/kg/day). In the 5.0 mg/kg/day group, EHDP-induced effects proved reversible with mineralization evident as early as 3 weeks following drug withdrawal. In mature beagle dogs EHDP proved to have dose-dependent and reversible inhibitory effects on secondary fracture healing.
Regulation of sugar transport by the bacterial phosphoenolpyruvate: glucose phosphotransferase system (1984)

Conference Article| April 01 1984 Regulation of sugar transport by the bacterial phosphoenolpyruvate: glucose phosphotransferase system D. FOX; D. FOX 1Department of Biology and the McCollum-Pratt Institute, The Johns Hopkins University, Baltimore, MD 21218, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar M. KUKURUZINSKA; M. KUKURUZINSKA 1Department of Biology and the McCollum-Pratt Institute, The Johns Hopkins University, Baltimore, MD 21218, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar K. D.-F. LIU; K. D.-F. LIU 1Department of Biology and the McCollum-Pratt Institute, The Johns Hopkins University, Baltimore, MD 21218, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar N. D. MEADOW; N. D. MEADOW 1Department of Biology and the McCollum-Pratt Institute, The Johns Hopkins University, Baltimore, MD 21218, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar D. SAFFEN; D. SAFFEN 1Department of Biology and the McCollum-Pratt Institute, The Johns Hopkins University, Baltimore, MD 21218, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar S. ROSEMAN S. ROSEMAN 1Department of Biology and the McCollum-Pratt Institute, The Johns Hopkins University, Baltimore, MD 21218, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1984) 12 (2): 155–157. https://doi.org/10.1042/bst0120155 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation D. FOX, M. KUKURUZINSKA, K. D.-F. LIU, N. D. MEADOW, D. SAFFEN, S. ROSEMAN; Regulation of sugar transport by the bacterial phosphoenolpyruvate: glucose phosphotransferase system. Biochem Soc Trans 1 April 1984; 12 (2): 155–157. doi: https://doi.org/10.1042/bst0120155 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: PEP, phosphoenolpyruvate, PTS, phosphoenolpyruvate: glucose phosphotransferase system This content is only available as a PDF. © 1984 Biochemical Society1984 Article PDF first page preview Close Modal You do not currently have access to this content.
Discharge Coefficient Measurements of Film-Cooling Holes With Expanded Exits (1997)

This paper presents the discharge coefficients of three film-cooling hole geometries tested over a wide range of flow conditions. The hole geometries include a cylindrical hole and two holes with a diffuser shaped exit portion (i.e. a fanshaped and a laidback fanshaped hole). The flow conditions considered were the crossflow Mach number at the hole entrance side (up to 0.6), the crossflow Mach number at the hole exit side (up to 1.2), and the pressure ratio across the hole (up to 2). The results show that the discharge coefficient for all geometries tested strongly depends on the flow conditions (crossflows at hole inlet and exit, and pressure ratio). The discharge coefficient of both expanded holes was found to be higher than of the cylindrical hole, particularly at low pressure ratios and with a hole entrance side crossflow applied. The effect of the additional layback on the discharge coefficient is negligible.
Lightcurve and Color of Near-Earth-Asteroid 1989ML (1999)

Abstract The asteroid of 1989ML is an Amor type near-earth-asteroid, which is one of the most accessible asteroids by spacecraft, and consequently it has been selected as a backup target of the Japanese sample return mission, MUSES-C. In January 1996, the brightness of 1989ML had been brighter than 20-magnitude in R-band and we succeeded to observe it using a 1.05-m schmidt telescope with 1K CCD detector at Kiso Observatory, Japan. From the analysis of the data obtained for four nights, it is found that the rotational period of 1989ML may be 19 or 32 hours, and the amplitude of its brightness variation is about 1 magnitude in R-band. We have performed also VRI band colorimetry and found that the color of 1989ML is similar to that of C-type asteroid.
Public Debt, North and South (1994)

Debt, Deficits and Exchange Rates presents recent work by Helmut Reisen on current international monetary problems in East Asia and Latin America. Written over the last four years, these papers are readily accessible and of immediate policy relevance.
Determination of film stresses during sputter deposition using an <i>i</i> <i>n</i> <i>s</i> <i>i</i> <i>t</i> <i>u</i> probe (1985)

Previous work has established that the internal stresses and physical properties of sputter-deposited metals can be markedly affected by relatively small changes in the sputtering process. For instance, lowering the gas pressure or raising the discharge current can reverse the stress from tensile to compressive and, at the same time, produce more bulklike properties in the resultant coatings. Consequently, film stress observations can be utilized to map out the nature of the material produced in a given coating process and locate the boundary of the bulklike deposition regime as a function of process parameters. A principal obstacle to the implementation of this technique has been the laborious procedure of generating individual samples over a matrix of different process conditions. Residual film stresses were then determined by observing the resulting curvature of the thin substrates. In the present work substrate deflection was sensed capacitively using a miniature probe that was inserted into the deposition chamber and monitored in a remote manner. The probe signal was linear with film thickness, enabling detection of intrinsic stress in molybdenum layers as thin as 30 nm with sensitivity undiminished by multiple applications. The known compressive-to-tensile stress transition was accurately reproduced by the probe with significant additional detail. Effects of discharge current, source proximity, and argon flow conditions in shifting the stress transition were readily mapped out.
Optical Access Networks and Advanced Photonics: Technologies and Deployment Strategies (2009)

"This book presents a comprehensive overview of emerging optical access network solutions to efficiently meet the anticipated growth in bandwidth demand" - Provided by publisher
Ceramic‐Polymer Dielectric Composites Produced via Directional Freezing (2009)

This chapter contains sections titled: Introduction Experimental Procedures Results and Discussion Conclusion
See Ourselves as Others See Us (1914)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTSee Ourselves as Others See UsCite this: Ind. Eng. Chem. 1914, 6, 1, 2Publication Date (Print):January 1, 1914Publication History Published online1 May 2002Published inissue 1 January 1914https://doi.org/10.1021/ie50061a001RIGHTS & PERMISSIONSArticle Views10Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (150 KB) Get e-Alerts