gebhart/patrepeval huggingface dataset:
A high-efficiency biotelemetry system for implanted electronic device (2002)

The development of an implanted micro-emitter having a considerable implantation depth needs a high-efficiency magnetic transcutaneous link. This paper describes a new system for the biotelemetry of internal signals. The system associates the highest performance class E power amplifier with the impedance modulation concept. The resistive load of the transmitter is influenced by the variation of the internal equivalent resistance, modulating this latter between two rails permits to modulate the amplitude of the external transmitter current and then transmitting internal digital data. Furthermore, the dependence of the modulation index on coupling factor allows to find the external coil correct position using a position feedback loop.
Tensile Stress Relaxation Studies of TiO<sub>2</sub> and Nanosilica Filled Natural Rubber Composites (2009)

Composites of natural rubber were prepared with TiO2 and nanosilica. The stress relaxation behavior of the composites under tension was studied with reference to the filler loading and strain level. It was observed that the rate of stress relaxation increases with increase in filler loading. The rate of stress relaxation was found to be higher for silica-filled NR compared to TiO2-filled NR. This is due to the high degree of agglomeration in silica compared to titanium dioxide filler. The effect of ageing on the stress decay was also investigated and the rate of stress relaxation was found to decrease after ageing. The experimental curves were fitted with the stretched Kohlrausch equation. From the fitting parameters, the relaxation time and the stretching exponent were estimated in order to understand the mechanism of the relaxation processes in the filled natural rubber composites.
Principles of neurotoxicology (2002)

Neurotoxicity can be defined as an adverse effect of chemicals on the structure or function of the central or peripheral nervous system (NRC, 1992). Structural alterations include changes in the morphology of the various cells or subcellular components. Functional changes include neurophysiological, neurochemical or behavioral alterations. Adverse effects of chemicals on the nervous system are a function of both the property of the chemical and the characteristics of the constituents of the nervous system (US EPA, 1994). This principle is important for understanding site-specific effects of chemicals in the nervous system due to of the relative complexity and heterogeneity of the various components of the nervous system. Adverse effects include chemical-induced changes that diminish the ability of the individual to survive, reproduce or adapt to the environment (US EPA, 1994). Adverse effects identified and studied in humans and animals include impaired muscle movements, alterations in sensory function, autonomic dysfunction, and disruption of cognitive functions such as learning, memory and attention (Anger, 1984, 1990).
Dynamic Modelling of Heart Rate Response Under Different Exercise Intensity (2010)

Heart rate is one of the major indications of human cardiovascular response to exercises. This study investigates human heart rate response dynamics to moderate exercise. A healthy male subject has been asked to walk on a motorised treadmill under a predefined exercise protocol. ECG, body movements, and oxygen saturation (SpO2) have been reliably monitored and recorded by using non-invasive portable sensors. To reduce heart rate variation caused by the influence of various internal or external factors, the designed step response protocol has been repeated three times. Experimental results show that both steady state gain and time constant of heart rate response are not invariant when walking speed is faster than 3 miles/hour, and time constant of offset exercise is noticeably longer than that of onset exercise.
Assessment of viscous and elastic properties of sub-wavelength layered soft tissues using shear wave spectroscopy: Theoretical framework and in vitro experimental validation (2011)

In elastography, quantitative imaging of soft tissue elastic properties is provided by local shear wave speed estimation. Shear wave imaging in a homogeneous medium thicker than the shear wavelength is eased by a simple relationship between shear wave speed and local shear modulus. In thin layered organs, the shear wave is guided and thus undergoes dispersive effects. This case is encountered in medical applications such as elastography of skin layers, corneas, or arterial walls. In this work, we proposed and validated shear wave spectroscopy as a method for elastic modulus quantification in such layered tissues. Shear wave dispersion curves in thin layers were obtained by finite-difference simulations and numerical solving of the boundary conditions. In addition, an analytical approximation of the dispersion equation was derived from the leaky Lamb wave theory. In vitro dispersion curves obtained from phantoms were consistent with numerical studies (deviation <1.4%). The least-mean-squares fitting of the dispersion curves enables a quantitative and accurate (error < 5% of the transverse speed) assessment of the elasticity. Dispersion curves were also found to be poorly influenced by shear viscosity. This phenomenon allows independent recovery of the shear modulus and the viscosity, using, respectively, the dispersion curve and the attenuation estimation along the propagation axis.
Perceptions of Open Access Publishing among Academic Journal Editors in China (2007)

Open access publishing is examined from the perspective of academic journal editors in mainland China, Hong Kong, and Taiwan. In addition to providing background information on academic publishing in China, the author incorporates interviews with two editors from open access and four from traditional subscription-based journals in the region. The editors share their general views on Chinese academic publishing and reflect on how open access has or could affect their publications. The editors comment on such issues as the economic viability of open access publishing in China and the potential benefits and challenges faced by Chinese
V2V-Intersection Management at Roundabouts (2013)

<div class="section abstract"><div class="htmlview paragraph">More than 44% of all automotive crashes occur in intersections. These incidents in intersections result in more than 8,500 fatalities and approximately 1 million injuries each year in USA. It is also established that roundabouts are safer than junctions. According to a USDOT study, when compared with the junctions they replaced, roundabouts have 40% fewer vehicle collisions, 80% fewer injuries and 90% fewer serious injuries and fatalities.</div><div class="htmlview paragraph">In earlier work, we have proposed a family of vehicular network protocols, which use Dedicated Short Range Communications (DSRC) and Wireless Access in Vehicular Environment (WAVE) technologies to coordinate a vehicle's movement through intersections. We have shown that vehicle-to-vehicle (V2V) communications can be used to avoid collisions at the intersection and also significantly decrease the trip delays introduced by traffic lights and stop signs. In this paper, we investigate the use of our proposed V2V-intersection protocols for autonomous driving at roundabouts. We have extended our hybrid emulator-simulator called AutoSim to implement realistic map and mobility models to study traffic flow at roundabouts and have implemented our V2V-intersection protocols on roundabouts. Using a simulated environment, we quantify the benefits of our proposed intersection protocols in terms of safety and throughput enhancements while negotiating roundabouts.</div></div>
Thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells (1999)

Thyroid hormone [L-thyroxine (T4)] rapidly induced phosphorylation and nuclear translocation (activation) of mitogen-activated protein kinase (MAPK) in HeLa and CV-1 cells in the absence of cytokine or growth factor. A pertussis toxin-sensitive and guanosine 5'-O-(3-thiotriphosphate)-sensitive cell surface mechanism responsive to T4 and agarose-T4, suggesting a G protein-coupled receptor, was implicated. Cells depleted of MAPK or treated with MAPK pathway inhibitors showed reduced activation of MAPK and of the signal transducer and activator of transcription STAT1alpha by T4; they also showed reduced T4 potentiation of the antiviral action of interferon-gamma (IFN-gamma). T4 treatment caused tyrosine-phosphorylated MAPK-STAT1alpha nuclear complex formation and enhanced Ser-727 phosphorylation of STAT1alpha, in the presence or absence of IFN-gamma. STAT1alpha-deficient cells transfected with STAT1alpha containing an alanine-for-serine substitution at residue 727 (STAT1alphaA727) showed minimal T4-stimulated STAT1alpha activation. IFN-gamma induced the antiviral state in cells containing wild-type STAT1alpha (STAT1alphawt) or STAT1alphaA727; T4 potentiated IFN-gamma action in STAT1alphawt cells but not in STAT1alphaA727 cells. T4-directed STAT1alpha Ser-727 phosphorylation is MAPK mediated and results in potentiated STAT1alpha activation and enhanced IFN-gamma activity.
Unexpected Crystal and Domain Structures and Properties in Compositionally Graded PbZr<sub>1‐<i>x</i></sub>Ti<sub><i>x</i></sub>O<sub>3</sub> Thin Films (2013)

Synthesis of compositionally graded versions of PbZr(1-x)Ti(x)O3 thin films results in unprecedented strains (as large as ≈4.5 × 10(5) m(-1)) and correspondingly unexpected crystal structures, ferroelectric domain structures, and properties. This includes the observation of built-in electric fields in films as large as 200 kV/cm. Compositional and strain gradients could represent a new direction of strain-control of materials.
Embedding self-similar watermarks in the wavelet domain (2002)

A wavelet-based watermarking method for still images is presented. Watermarks are composed of scaled versions of circularly-symmetric pseudo-random 2D signals in order to attain a spatial self-similar structure with respect to a cartesian grid. Embedding and detection are performed in the wavelet domain thus allowing multi-level detection. The novelty of the method lies in the use of self-similar watermarks (quasi scale-invariant), expected to be robust against geometric transformations, especially scaling. The approach proves rather efficient against many kinds of distortions, such as linear and nonlinear filtering, JPEG and wavelet compression, scaling, cropping and rotation.
Unmanned loading operation by autonomous wheel loader (2009)

Authors developed a real sized autonomous wheel loader “Yamazumi-4,” and succeeded to execute the unmanned and autonomous task including excavating, scooping a pile, hauling and loading it on a dump truck, appearing in the mining work typically. This paper describes on the whole task control that consists of pile position measurement by stereo vision, path planning, path following control, pile excavating control, and loading control.
Abstract 239: CD8+ T Cells Elicited by an ApoB-100 Related Peptide Vaccine Mediate Protection Against Angiotension II-induced Hypertension and Renal Fibrosis (2013)

Background: T cells play an important role in angiotensin II (AngII)-induced hypertension but the specific subtype involved remains unknown. We recently reported that immunization with apoB-100 related peptide p210 modified CD8+ T cell function, and reduced mean blood pressure (BP) and renal inflammation in AngII-infused apoE (-/-) mice. In this study, we assessed the role of CD8+ T cells in p210 vaccine mediated renal protection. Method and Results: ApoE (-/-) mice were immunized with p210/cBSA/Alum (p210; 100 μg) at 7, 10, and 12 weeks of age. Mice receiving PBS or cBSA/Alum (cBSA) served as controls. At 10 weeks of age, mice were subcutaneously implanted with an osmotic pump which released AngII (1 mg/Kg/min), and were euthanized 4 weeks later. Flow cytometric analysis showed p210 treated mice had significantly increased CD8+CD25+IL-12+ splenic T cells indicating CD8+ T cell activation (Table). Renal fibrosis assessed by Masson-Trichrome staining and pro-fibrotic gene expression was significantly reduced in p210 vaccine treated group (Table). P210 immunized mice with CD8+ T cell depletion by a monoclonal antibody (Ab) developed higher mean BP compared to similarly treated mice receiving isotype Ab or no Ab injection ( no Ab injection = 123±1 mmHg, CD8 Ab = 132±1 mmHg*, isotype Ab = 123±2 mmHg, *p<0.05, N=8, 7, 5 respectively, *p<0.05 vs no Ab injection.). Depletion of CD8+ T cells also increased renal fibrotic gene expression compared to no Ab injection (Table). Conclusion: CD8+ T cells elicited by an apoB-100 related peptide vaccine mediate protection against AngII-induced hypertension and renal fibrosis.
Structure-Function Analysis of P-selectin-Sialyl Lewisx Binding Interactions (1996)

P-selectin is a vascular cell adhesion molecule that is expressed on the surface of platelets and endothelial cells in response to inflammatory stimuli. It is believed to aid in the binding and recruitment of leukocytes to inflamed tissue. P-selectin adhesion to leukocytes is mediated by the amino-terminal lectin domain that binds the sialyl LewisX (sLeX) carbohydrate (Neu5Acalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAc). Neither the three-dimensional structure of P-selectin nor the protein-carbohydrate interactions that mediate the binding of P-selectin to the sLeX carbohydrate have been determined. The most closely related protein for which a ligand-bound three-dimensional structure has been resolved is the rat mannose-binding protein (Weis, W. I., Drickamer, K., and Hendrickson, W. A. (1992) Nature 360, 127-134). Using the known binding interactions that occur between the rat mannose-binding protein and its ligand (oligomannose) as a template, we have used site-directed mutagenesis to substitute Ala-77 with lysine. This substitution changed P-selectin-carbohydrate binding specificity from sLeX to oligomannose. Further substitution altered the binding preference from mannose to galactose in a predictable manner. These results indicate that P-selectin binds sLeX in a shallow cleft that is similar to the mannose-binding protein saccharide-binding cleft. Additionally, we present an extensive mutagenic analysis of P-selectin Lys-113, a residue that has previously been implicated in P-selectin binding to both sLeX and 3-sulfated galactosylceramide (sulfatide). Our analysis demonstrates that Lys-113 is probably not involved in P-selectin binding to either sulfatide or sLeX. Functionally, it appears that P-selectin has retained a conserved carbohydrate and calcium coordination site that enables it to bind carbohydrate in a manner that is quite similar to that which has been determined for the rat mannose-binding protein.
Bio-immunotherapy for cancer in experimental studies and clinical application: current status and future challenges. (1995)

Although successful treatment of patients with primary tumor by conventional surgery and radiotherapy is often possible, death frequently results from tumor metastases. Since metastasis has already occurred in many cancer patients at the time of diagnosis, a major emphasis of cancer treatment is and will continue to be the prevention or successful management of tumor metastases. Systemic chemotherapy has been widely used in the past in the hope of preventing or controlling micrometastases. The results of this treatment have been disappointing with little impact on survival in the vast majority of solid tumors. Bio-immunotherapy has emerged as another modality and is finding acceptance and use in treating patients with cancer. The role of bio-immunotherapy in traditional surgery, radiotherapy, chemotherapy and hyperthermia will be discussed. In order to evaluate new and innovative treatments, we and others have used murine models of erythroleukemia and solid tumors with metastatic potential to assess the effects in vivo of bio-immunotherapy. Tumor metastases can be dampened and immunosuppression restored by bio-immunotherapy, especially when used in combination with other forms of treatment. Most of the combination treatments used in animal models are encouraging but are by no means totally adequate or curative yet. The molecular basis of cancer is now understood to involve activation of dominant oncogenes and inactivation of tumor suppressor genes. These genetic events may represent novel targets for cancer treatment. The potential use and ethical implications of gene transfer to alter the behavior of somatic cells in patients with cancer has been noted. Also reported is genetic immunomodulation by introducting genes for cytokines into tumor cells or lymphocytes to stimulate a cytotoxic immune response against the tumor. As with bone marrow, human cord blood can be used for transplantation in the autologous, related allogeneic and unrelated allogeneic settings, and as a target cell for gene treatment. It is believed that the greatest therapeutic results of bio-immunotherapy, including biological response modifiers, cytokines, gene treatment and bone marrow transplantation, will come in combination with other established effective modalities including surgery, radiation treatment, chemotherapy and hyperthermia in the treatment of patients with cancer.
Petroleum Well Construction (1998)

Introduction to Drilling and Well Completions. Directional Drilling. Horizontal, Multilateral, and Multibranch Wells in Petroleum Production Engineering. Measurement-While-Drilling (MWD), Logging-While Drilling (LWD), and Geosteering. Drilling Fluids. Rock Mechanics in Wellbore Construction. Closing and Tubing Design. Primary Cementing. Formation-Fluid Migration after Cementing. Cement-Sheath Evaluation. Remedial Cementing. Completion Fluids. Perforating. Completion Hardware. Inflow Performance/Tubing Performance. Artificial-Lift Completions. Well Stimulation. Sand Stabilization and Exclusion. High-Permeability Fracturing. Water Control. Designing Well Completions for the Life of the Field. Index.
Isolation of β-endorphin-related peptides from ox pituitary (1980)

Conference Article| December 01 1980 Isolation of β-endorphin-related peptides from ox pituitary D. E. MASSEY; D. E. MASSEY 1National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, U.K. Search for other works by this author on: This Site PubMed Google Scholar D. G. SMYTH D. G. SMYTH 1National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1980) 8 (6): 751–753. https://doi.org/10.1042/bst0080751 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation D. E. MASSEY, D. G. SMYTH; Isolation of β-endorphin-related peptides from ox pituitary. Biochem Soc Trans 1 December 1980; 8 (6): 751–753. doi: https://doi.org/10.1042/bst0080751 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: h.p.l.c., high-pressure liquid chromatography This content is only available as a PDF. © 1980 Biochemical Society1980 Article PDF first page preview Close Modal You do not currently have access to this content.
Experimental tumor inhibitors. Antitumor activity of esters of .omega.-aryl-psi-nitro-psi-alken-1-ol and related compounds (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExperimental tumor inhibitors. Antitumor activity of esters of .omega.-aryl-psi-nitro-psi-alken-1-ol and related compoundsKwang-Yuen Zee-Cheng and Chia-Chung ChengCite this: J. Med. Chem. 1969, 12, 1, 157–161Publication Date (Print):January 1, 1969Publication History Published online1 May 2002Published inissue 1 January 1969https://pubs.acs.org/doi/10.1021/jm00301a042https://doi.org/10.1021/jm00301a042research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Conjugation of LG Domains of Agrins and Perlecan to Polymerizing Laminin-2 Promotes Acetylcholine Receptor Clustering (2005)

Neuromuscular junction (NMJ) assembly is characterized by the clustering and neuronal alignment of acetylcholine receptors (AChRs). In this study we have addressed post-synaptic contributions to assembly that may arise from the NMJ basement membrane with cultured myotubes. We show that the cell surface-binding LG domains of non-neural (muscle) agrin and perlecan promote AChR clustering in the presence of laminin-2. This type of AChR clustering occurs with a several hour lag, requires muscle-specific kinase (MuSK), and is accompanied by tyrosine phosphorylation of MuSK and betaAChR. It also requires conjugation of the agrin or perlecan to laminin together with laminin polymerization. Furthermore, AChR clustering can be mimicked with antibody binding to non-neural agrin, supporting a mechanism of ligand aggregation. Neural agrin, in addition to its unique ability to cluster AChRs through its B/z sequence insert, also exhibits laminin-dependent AChR clustering, the latter enhancing and stabilizing its activity. Finally, we show that type IV collagen, which lacks clustering activity on its own, stabilizes laminin-dependent AChR clusters. These findings provide evidence for cooperative and partially redundant MuSK-dependent functions of basement membrane in AChR assembly that can enhance neural agrin activity yet operate in its absence. Such interactions may contribute to the assembly of aneural AChR clusters that precede neural agrin release as well as affect later NMJ development.
Control system analysis and synthesis for a six degree-of-freedom universal force-reflecting hand controller (1980)

A six degree-of-freedom joystick with feedback motors, called the Force-Reflecting Hand Controller (FRHC) is used as control input for the human operator in a teleoperator system. The geometric and dynamic properties of the FRHC are entirely different from those of the manipulator being controlled. The paper discusses the analysis and synthesis of the control loop between the FRHC and the robot arm and examines the necessary position and force transformations. The controller is implemented through a dedicated minicomputer.