gebhart/patrepeval huggingface dataset:
Damage to Schistosomula of <i>Schistosoma Mansoni</i> Induced Directly by Eosinophil Major Basic Protein (1979)

Abstract Major basic protein (MBP) from both human and guinea pig eosinophils has been found to damage schistosomula of Schistosoma mansoni at concentrations as low as 2 × 10-5 M. This damage can be detected both by light microscopy and by measurement of release of 51Cr from labeled larvae. Damage is attributable in part to the basic properties of the molecule, since some other cations of comparable molecular weight, such as protamine and polyarginine, have comparable effects at equimolar concentrations. Other cations, however, fail to mediate damage, indicating that simply the possession of a positive charge is a necessary but insufficient prerequisite. The action of MBP is not selective, since mammalian target cells can also be damaged. Damage induced by MBP is associated with uptake of the material onto the parasite's surface, and both uptake and damage can be blocked by heparin. In addition, it has been found that MBP is released during the antibody-dependent reaction between human eosinophils and schistosomula, and can be detected both on the surface of the organism and free in small quantities in the supernatant. Damage mediated directly by eosinophils is not inhibitable by heparin, suggesting that the effect of eosinophils is attributable to the local release of high concentrations of MBP into a sequestered site adjacent to the parasite surface, rather than to a generalized release into the supernatant. These findings suggest that release of MBP may represent a major mechanism of eosinophil-mediated damage to schistosomula and, since MBP is uniquely associated in high quantities with the eosinophil, these results provide a partial explanation for the selective action of eosinophils on antibody-coated schistosomula.
Abnormal proteolysis (DIC)—successful treatment with antithrombin III concentrate and a concentrate containing F XIII and native von Willebrand factor (1989)

Two patients with life-threatening disseminated intravascular coagulation (DIC) syndrome, one caused by Gram-negative bacteria and one by premature separation of the placenta, are described. Specific substitution was given by antithrombin III concentrate and AHF-Kabi, a low purity factor VIII concentrate containing native von Willebrand factor and factor XIII. The treatment quickly returned the extremely low levels of antithrombin III, factor VIII:C, fibrinogen and factor XIII, initially found, to normal, and also returned the multimeric pattern of von Willebrand factor to normal. This resulted in diminished bleeding, enabling surgical treatment of the underlying disease.
Power-Efficient Oscillator-Based Readout Circuit for Multichannel Resonant Volatile Sensors (2012)

This work presents a multichannel electronic nose system that enables a range of novel applications owing to high sensitivity, low form factor and low power consumption. Each channel is based on a combination of doubly-clamped piezoelectric MEMS resonators and CMOS oscillator-based readout designed in TSMC 0.25 μm technology. Using "application specific" polymer coatings, the individual resonators can be tuned to detect mixtures of volatile organic compounds (VOCs). This system achieves ppm-level theoretical limit of detection for ethanol which paves the way towards a broad range of applications such as personalized health and environment air quality.
Gametocyte-Forming and Non-Gametocyte-Forming Clones of Plasmodium Falciparum (1984)

Three clones have been prepared from the Honduras I/CDC strain of Plasmodium falciparum by a method of microscopic selection. One of these (HB-2) does not form gametocytes whereas the others (HB-1 and HB-3) do. All three are as resistant to pyrimethamine as the original line, and all three form knobs on the erythrocyte surface.
Quality sewage products the environment, the community and the market place in Illawarra (1994)

Solutions to deal with the public health and environmental needs associated with sewage wastes generated by our urbanised community in the Illawarra have typically involved significant engineering input into the specification, design, construction and operation of sewerage systems (including sewage treatment plants). Today the technology exists to take sewage from the community and clean it up to potable water standards (at a cost) . Such solutions are increasingly becoming more technically complex, not only because of the need to meet higher standards, but also because of the developing new technologies that can be applied to treating sewage.
Design and Synthesis of Lignin-Based Flexible Supercapacitors (2019)

Due to the immense demand for flexible supercapacitors, it is important to develop low-cost and smarter solutions. To date, supercapacitors made of eco-friendly materials have been either expensive or of limited use. Herein, we report a solid-state, lightweight, low-cost, and plant-based supercapacitor for applications in flexible electronics. The asymmetric supercapacitor is made of MnO2 deposited on activated carbon and lignin as a substrate using hydrothermal deposition. With Al/AC/lig-MnO2 anode and Al/AC cathode, the supercapacitor is assembled using a poly(vinyl alcohol) (PVA)/H3PO4 gel electrolyte. Morphological characterization is conducted using microtomography and scanning electron microscope. Electrochemical performance is assessed using cyclic charge–discharge, cyclic voltammetry, and electrochemical impedance spectroscopy. A series of compositions of AC:lignin:MnO2 are optimized for best performance. After 2000 cycles, the specific capacitance obtained at 6.01 mA g–1 is 5.52 mF cm–2, which is up to 13 times reported. Retention is 98.7% after 1000 cycles and 97.5% after 2000 cycles. The maximum energy density, power density, and Coulombic efficiency obtained are 14.11 Wh kg–1, 1 kW kg–1, and 98%, respectively. The favorable electrochemical performance makes it useful for a wide variety of electronics. This new approach to fabricate electrodes from green sources, with constituent optimization and cost-effectiveness, marks an important step toward green energy technology development.
Analisi del periodo di AE UMa con dati disomogenei. Invito all'osservazione. (2009)

L’idea di questo lavoro è nata dalla volontà di analizzare i dati di AE UMa, raccolti indipendentemente dagli autori, frutto di osservazioni filtrate e non, ottenute con una diversa strumentazione ed in condizioni operative diverse. Più in generale si è cercato di verificare la possibilità di utilizzare delle osservazioni non omogenee tra loro per lo studio dell’analisi del periodo, confrontandone i risultati con quelli pubblicati in letteratura.
ChemInform Abstract: REGIOSPECIFIC SYNTHESIS OF AROMATIC COMPOUNDS VIA ORGANOMETALLIC INTERMEDIATES. 3. N‐ALKYL‐SUBSTITUTED BENZENE (1984)

Abstract 1,3,5‐Trichlorbenzol (I) reagiert in Gegenwart des angegebenen Ni‐Katalysators mit Grignardverbiitdungen (II) in hohen Ausbeuten zu den Trialkylbenzolen (III).
Metabolic unit volume: A quantitative method for assessing the efficacy of cancer treatment using FDG PET/CT (2008)

481 Objectives: To establish a quantitative measure of metabolically active tumor in cancer patients to monitor disease progression and the effects of treatment. A definition for ‘Metabolic Unit Volume’ (MUV) is proposed, and we will demonstrate how the MUV is superior for following disease progression and treatment effects over the standard RECIST criteria. Methods: This retrospective study used 12 subjects with Hodgkin’s lymphoma. PET/CT images were analyzed with MUVs defined as ∑ (mean SUV)(lesional volume in mL) over all lesions. The volume of interest is defined by the boundaries of the lesion on attenuation correction CT. Eight of these subjects had accompanying diagnostic CTs, and the RECIST criteria were correspondingly applied to assess for disease progression. Results: The average percent decline in MUV for the 11 subjects demonstrating improvement in disease was 90.2% while the average percent decline in diameter based on RECIST criteria was 52.9% for the 7 subjects with CTs. The percent increase in MUV for the subject who showed progression of disease was 58.3% while the percent DECREASE in diameter by RECIST criteria was 4.7%. Conclusions: The percent change in MUV correlates better with actual disease state than does the percent change demonstrated by the RECIST criteria. Our findings suggest that MUV is a practical quantitative measure to better assess the efficacy of treatment and is an improvement over qualitative visual assessment.
Epitopes of human immunodeficiency virus regulatory proteins tat, nef, and rev are expressed in normal human tissue. (1992)

The expression of regulatory proteins tat, rev, and nef of human immunodeficiency virus type-1 (HIV-1) and tat of HIV-2 was studied in frozen sections of lymph nodes from HIV-1-infected individuals, and various tissues from uninfected persons. In HIV-1-positive lymph nodes, monoclonal antibodies to HIV-1-tat stained solitary cells in the germinal centers and interfollicular zones, and vascular endothelium. Staining by an anti-nef monoclonal antibody was restricted to follicular dendritic cells, whereas anti-rev antibody bound to fibriohistiocytes and high endothelial venules. The antibodies used labeled several cell types in tissues from uninfected individuals. Anti-HIV-1-tat antibodies labeled blood vessels and Hassall's corpuscles in skin and thymus; goblet cells in intestinal tissue and trachea; neural cells in brain and spinal cord; and zymogen-producing cells in pancreas. Anti-rev antibody stained high endothelial venules, Hassall's corpuscles and histiocytes. One anti-nef antibody solely stained follicular dendritic cells in spleen, tonsil, lymph node and Peyer's patches, whereas two other anti-nef antibodies bound to astrocytes, solitary cells in the interfollicular zones of lymph nodes, and skin cells. The current results hamper the immunohistochemical study for pathogenetic and diagnostic use of HIV regulatory protein expression in infected tissue specimens or cells.
AUGMENTED REALITY MARKERS AS SPATIAL INDICES FOR INDOOR MOBILE AECFM APPLICATIONS (2012)

ABSTRACT: This paper presents a new methodology for utilizing Augmented Reality (AR) fiducial markers on mobile devices (smart phone/tablet) for indoor Architecture, Engineering, Construction, and Facilities Management (AECFM) applications such as navigation and inspection. On one hand, previous efforts on such applications focused mainly on exploring traditional non-visual-sensor-based methods to track user&apos;s position continuously, ignoring the advantage that in most of the built environment, human inspectors can easily navigate themselves to destinations given that they can make correct decisions at a set of discrete critical spatial locations (corner of hallway, stairs etc.). On the other hand, traditionally fiducial markers are extensively used to recover user&apos;s pose and thus serve as table-top AR display surface, benefiting from its cost-efficiency and high flexibility. A different view that combines these two observations is to attach these markers at critical locations whose global positions and orientations are known in advance, treating markers as spatial indices which help the automatic identification of key locations. Upon recognizing the marker, as well as estimating the relative pose between the user and marker, user&apos;s pose in the global coordinate frame can be calculated. Then decisions can be automatically made and users are guided to their destinations by 3D graphical instructions. An example application for complex indoor environment way-finding is built on Android platform and tested which demonstrates the efficiency of the proposed method.
Psoriasis patients who are homozygous for the HLA-Cw*0602 allele have a 2.5-fold increased risk of developing psoriasis compared with Cw6 heterozygotes (2003)

Homozygosity for the gene in the major histocompatibility complex region has a major additive impact on the risk of developing psoriasis and predisposes to an earlier disease onset, but does not have any marked influence on the phenotype or the severity of the disease.
Caught in the Current (2007)

Christie Harris presente sa carriere litteraire, qu'elle a consacree en tres grande partie a la jeunesse; elle rappelle le role de pionniere qu'elle a joue dans la sauvegarde et la recension des legendes et des recits amerindiens.
Assembly of Gold Nanoclusters on Silicon Surfaces (2002)

The electrostatic association between mercaptosuccinic acid-coated gold clusters, about 2 nm in diameter, and amine silane derivatized silicon was examined. Relatively good coverage takes place in the pH range between 5 and 6 that coincides with the dissociation of the acid coating on the gold clusters. The latter was established by IR spectroscopy taking advantage of the typical carboxylate vibrations that differ from the protonated species. The pKa value of the gold-bound acid was estimated to be 1.3 units higher than that on the free acid. Such displacements are anticipated for monolayers of bases or acids, but it is smaller in the spherical cluster than on flat surfaces. The microstructure of the films may be manipulated through control of pH, contact time, and the nature of the crystalline substrate.
Health Benefits of Plants Pigments: The Magic of Colour (2014)

Studies related to plant pigments are one of the oldest areas of work in plant science. Nature produces a variety of compounds appropriate for food colouring called pigments that absorb some wavelengths of light and reflect others. The improvement of dietary values of crops to supplement the diet with nutrients plays an important role in the treatment of many diseases and to improve the quality of life. From an economic perspective, the most obvious contribution of plant pigments is with regard to consumer choice of fresh fruits, vegetables and floricultural products. The impact of the pigments is often much wider i.e., they are of economic importance as flavour and colour components of different food components, teas, wine and other beverages, as natural food colorants, as plant defence agents and for amelioration of damaging UV light. This article presents a general overview of the major plant pigment groups and their diversity and function in generating the range of colours observed in plants and impact on human health.
Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage–response thresholds (2009)

The expression of ASPP2 (53BP2L), a proapoptotic member of a family of p53-binding proteins, is frequently suppressed in many human cancers. Accumulating evidence suggests that ASPP2 inhibits tumor growth; however, the mechanisms by which ASPP2 suppresses tumor formation remain to be clarified. To study this, we targeted the ASPP2 allele in a mouse by replacing exons 10-17 with a neoR gene. ASPP2(-/-) mice were not viable because of an early embryonic lethal event. Although ASPP2(+/-) mice appeared developmentally normal, they displayed an increased incidence of a variety of spontaneous tumors as they aged. Moreover, gamma-irradiated 6-week-old ASPP2(+/-) mice developed an increased incidence of high-grade T cell lymphomas of thymic origin compared with ASPP2(+/+) mice. Primary thymocytes derived from ASPP2(+/-) mice exhibited an attenuated apoptotic response to gamma-irradiation compared with ASPP2(+/+) thymocytes. Additionally, ASPP2(+/-) primary mouse embryonic fibroblasts demonstrated a defective G(0)/G(1) cell cycle checkpoint after gamma-irradiation. Our results demonstrate that ASPP2 is a haploinsufficient tumor suppressor and, importantly, open new avenues for investigation into the mechanisms by which disruption of ASPP2 pathways could play a role in tumorigenesis and response to therapy.
Detection of homodimer formation of CD99 through extracelluar domain using bimolecular fluorescence complementation analysis (2007)

Although various functions of CD99 have been reported, such as apoptosis and homotypic aggregation of thymocyte and transendothelial migration of immune cells, biochemical/molecular natures of CD99 are still elusive. Using mouse CD99 gene, we show that CD99 forms homodimer through its extracellular domain. Expression of mouse CD99 is up-regulated on T cells after CD3-mediated activation, like the case for human CD99. The potential of CD99 to form homodimer was tested with a recently developed bimoleular fluorescence complementation analysis (BiFC). In BiFC analysis, the dimerization-induced fluorescence was strong near the perinuclear region and was faded at the cell membrane. However, surface expression of CD99 was still detected by flow cytometry, suggesting that CD99 either in monomer form or in association with other molecules exists on the cell surface. In BiFC analysis using CD99 mutants with its extracellular, transmembrane, or cytosolic domains changed to corresponding human CD4 domains, the mutant replaced with human CD4-extracellular domain did not produce fluorescence. Purified soluble CD99-Fc fusion proteins bound to CD99-Fc immobilized onto the gold sensor chip in surface plasmon resonance analysis, confirming that the extracellular domain was responsible for dimer formation. Intracytoplasmic staining for CD99 expression in the thymocytes and mature T cells showed that most of the cells, even the cells with low surface level of CD99, contained the molecule inside the cell. Our results suggest that majority of CD99 homodimers may exit in the cell and be exported to the cell surface, dissociating from each other, after a certain regulatory signal is delivered.
ECG Electrodes: A Study of Electrical and Mechanical Long‐term Properties (1979)

The long-term properties of commercially available ECG-electrodes were studied by investigating the parameters: polarization potential, electrical impedance, adhesion, and skin reactions during a period of 7 days. As expected, the most stable polarization potentials were obtained for Ag/AgCl electrodes. Certain simple disposable electrodes showed large polarization potential variations. The most stable electrode impedance was obtained for disposable electrodes with stable adhesion and equipped with an electrode cup or similar. Unchanged adhesion and mechanical properties during the test period were shown by the disposable electrodes with a large self-adhesive collar.
Changes in Peak Flow, Symptom Score, and the Use of Medications During Acute Exacerbations of Asthma (1996)

Changes in symptom score and peak expiratory flow (PEF) and the use of medications during the first acute exacerbation of asthma were studied in 41 patients and matched controls who took part in a panel study. An acute exacerbation was defined as the presence of at least one of the following: any unscheduled physician visit, visit to an emergency room, or hospitalization for treatment of asthma; a decrease in PEF by 30% from the patient's best reading; an increase in asthma symptoms during the day and night for over 48 h and not responding to usual medications; and the commencement or doubling of the dose of oral or inhaled steroids for any of the foregoing reasons. Data from -9 to -7 d before the onset of an acute exacerbation were taken as the baseline data, with which the values of the subsequent 14 d were compared. Significant increases in symptoms occurred before a significant reduction in PEF. None of the patients had a decrease of more than 30% in PEF before the onset of symptoms. Daily variation in PEF was not significantly increased from the baseline. Our results suggest that PEF monitoring is not as sensitive as a symptom diary for revealing acute exacerbations of asthma, and that a 30% decrease in PEF is too stringent a criterion for defining an acute exacerbation.
Efficient, Enantioselective Organocatalytic Synthesis of Trichostatin A (2006)

Abstract An efficient, highly stereocontrolled total synthesis of trichostatin A ( 1 ) has been achieved in 9 steps with 17.4 % overall yield and >99 % optical purity from readily available achiral starting materials. The key features of this synthesis include the L ‐proline‐promoted, highly enantioselective cross‐aldol reaction as a crucial step for the construction of the C‐6 chiral center and the minimization of racemization by final step oxidation of the OH group to a ketone at position 7.
Localization and mechanism of ventricular tachycardia by ice mapping 1 week after the onset of myocardial infarction in dogs. (1983)

We developed a new technique of "ice mapping" to localize the site of termination of ventricular tachycardia in dogs 4 to 8 days after the onset of myocardial infarction. During programmed stimulation-induced ventricular tachycardia, the epicardium was mapped by moving an ice probe with a 1 cm tip over the infarct, lateral border, and normal areas. In 31 of 46 morphologically distinct sustained ventricular tachycardias, a specific area could be found that reproducibly terminated ventricular tachycardia. During ventricular tachycardia, bridging or late diastolic electrical activity was recorded from ice termination sites. In vitro microelectrode studies of 10 ice termination sites revealed slow conduction, but no spontaneous or triggered automaticity or delayed afterdepolarizations. Conduction slowed to complete block when the Tyrode perfusate was cooled from 37 degrees to 27 degrees C. We conclude that ice mapping can physiologically localize a site responsible for maintenance of ventricular tachycardia by termination of the arrhythmia, and that the presence of bridging or late diastolic electrical activity, slow conduction with cooling-induced block, and absence of spontaneous or triggered automaticity or delayed afterdepolarizations suggest that local cooling terminates ventricular tachycardia by slowing or blocking conduction in a reentrant loop.
Expression of winged helix genes, BF‐1 and BF‐2, define adjacent domains within the developing forebrain and retina (1994)

One of the earliest events in the development of the central nervous system is the establishment of positional identity along the anteroposterior (A-P) axis of the neuroepithelium. In recent years, regulatory genes with regionally restricted expression in the neuroepithelium have been identified which are believed to specify its developmental fate. We have previously described Brain Factor-1 (BF-1), a winged helix (WH) transcription factor expressed in the telencephalic neuroepithelium (Tao and Lai, 1992) Neuron 8:957-966. Here we report the cloning of the mouse cDNA for a novel WH protein, BF-2. We show that BF-2 is a sequence-specific DNA binding protein with a binding specificity distinct from BF-1. Its expression in the CNS during embryogenesis is restricted to the rostral diencephalic neuroepithelium. The caudal boundary of BF-2 expression is at the zona limitans intrathalamica. Rostrally, the BF-2 expression domain is adjacent to that of BF-1. The expression domains of these two factors define a boundary within the developing forebrain neuroepithelium. The BF-1/BF-2 boundary also extends laterally to divide the optic stalk and the retina into nasal (anterior) and temporal (posterior) domains. These observations suggest that in addition to playing a role in the subdivision of the forebrain, these two WH factors may also function to establish positional information in the retinal neuroepithelium.
Conformal refinement of all-hexahedral element meshes based on multiple twist plane insertion. (2004)

Classical music causes acoustic trauma in musicians and should be recognized as a professional illness. Musicians are obliged to protect their hearing and to undergo regular check-ups.