gebhart/patrepeval huggingface dataset:
Regulation of expression of mouse interferon‐induced transmembrane protein like gene‐3, <i>Ifitm3</i> (<i>mil‐1, fragilis</i>), in germ cells (2004)

Mouse interferon-induced transmembrane protein (IFITM) gene, Ifitm3 (previously known as mil-1 and fragilis), is expressed in primordial germ cells (PGCs), in their precursors, and in germ cells of the fetal gonads (Saitou et al. [2002] Nature 418:293-300; Tanaka and Matsui [2002] Mech Dev 119S:S261-S267). By examining the expression of green fluorescent protein transgene under the control of DNA sequences flanking exon 1, we have identified domains that direct Ifitm3 transcription in PGCs and their precursors in gastrula stage and 13.5 days post coitum embryos. Germ cell-specific expression is achieved by the activity of a consensus element unique to the Ifitm genes, which may act to suppress Ifitm3 expression in somatic tissues. The lack of any influence of the interferon-stimulable response elements on transgene expression in the germ-line suggests that interferon-mediated response is not critical for activating Ifitm3.
A strategy to speed up formation and strengthen activity of biofilms at low temperature (2017)

The start-up period of biofilm reactors often takes a long time to obtain a mature and stable biofilm, especially at low temperature.
Site Differences in the Basal Metabolism of Subcutaneous Fat in Obese Women* (1981)

The basal capacity of femoral and abdominal fat to hydrolyze and store acylglycerols was investigated in obese women before and during 1 week of fasting. Before fasting, the lipolytic activity was lower and the lipoprotein lipase activity higher in femoral than in abdominal fat. During fasting, femoral fat lipoprotein lipase activity decreased and lipolytic activity increased to levels similar to those in abdominal fat. Acylglycerol syntheses were similar in the two fat depots before fasting, but decreased to a lower level at the abdominal than at the femoral site during fasting. Fat cell size decreased in the abdominal but not in the femoral site during fasting. Thus, regional variations in storage and mobilization of fat were found both in the fed and fasted states.
Decreased Soluble TWEAK Levels Predict an Adverse Prognosis in Patients with Chronic Stable Heart Failure (2009)

In contrast to other cytokines shown to be increased in heart failure patients, plasma levels of sTWEAK are significantly reduced in chronic stable heart failure. In addition, lower plasma levels of sTWEAK predict an adverse prognosis independent of established risk markers such as NT-proBNP.
On-chip patch-clamp sensor for solid-state nanopore applications (2011)

An integrated low-noise patch-clamp sensor is implemented for single-molecule DNA analysis using a solid-state nanopore. By adopting an instrumentation amplifier and a compensation switch for the headstage, the input-offset voltage and the deleterious effects of input parasitic capacitances are minimised. This high-sensitivity sensor amplifier was fabricated in a 0.35 µm CMOS process and tested with the solid-state nanopore also developed.
The Mayo Clinic-Canadian cooperative trial of sulfasalazine in active multiple sclerosis (1998)

Sulfasalazine does not prevent EDSS score progression in the subset of MS patients studied by this protocol. Treatments may improve relapse-related outcomes in MS, at least temporarily, without providing sustained slowing of EDSS progression. Phase III MS trials should be of sufficient length to determine a meaningful impact on disease course.
Diamond synthesis using a new type of high-pressure apparatus (1988)

A conversion of graphite into diamond was carried out by a new type of high-pressure apparatus using thermal stress. In this apparatus, high pressures and high temperatures were simultaneously generated by heating a metallic ball embedded in a ceramic cylinder. It was confirmed by an x-ray diffraction study that a part of the graphite sandwiched between the metallic ball and ceramic cylinder is transformed into diamond.
Identification and characterization of the functional amino acids at the active center of pig liver thioltransferase by site-directed mutagenesis (1991)

By using site-directed mutagenesis techniques, the essential amino acids at the catalytic center of porcine thioltransferase (glutaredoxin) were determined. Seven oligonucleotides were designed, synthesized, and used to construct mutants, ETT-C22S, ETT-C25S, ETT-C25A, ETT-R26V, ETT-K27Q, ETT-R26V: K27Q, and ETT-C78S:C82S, by altering their codons in pig liver thioltransferase cDNA/M13mp18 clones. Each of the thioltransferases was purified to homogeneity and its dithiol-disulfide exchange, and dehydroascorbate reductase activities were compared with those of the wild-type (ETT). Evidence was obtained that Cys22 was essential for catalytic activity, and the extremely low pKa value of its sulfhydryl group was facilitated primarily by Arg26. The role of Lys27 at the active center was different from that of Arg26 and may be important in stabilizing the E.S intermediate by electrostatic forces. The second pair of cysteines, Cys78 and Cys82, nearer the C terminus, were not directly involved in the active center, but may play a role in defining the native protein structure. The replacement of the original Cys with a Ser at position 25 increased rather than decreased the enzyme activity, suggesting that the proposed intramolecular disulfide bond between Cys22 and Cys25 is not necessary for the catalytic mechanism of the Ser25 mutant, but does not rule out such a mechanism for the wild-type enzyme.
Some factors affecting the incidence of potato brown rot. (1990)

The advantage of using paddle dryers (PD) in the production of sugars and 2nd generation ethanol from pretreated wheat straw was investigated. This machinery was employed in order to detoxify steam-exploded substrates and to mix different slurries in the hydrolysis step. The obtained hydrolysate was fermented by the yeast <i>Saccharomyces cerevisiae</i>. Acetic acid and furfural were reduced up to 11 and 26 fold respectively in the detoxified substrate. When fermentation was carried out at low solid suspension, the use of PD was as effective as water extraction in detoxifying exploded biomass, giving ethanol yields of 90% at 0.05 solid/liquid ratio (S/L) and 80% at 0.10 S/L. Moreover, by using PD the cellulose conversion yield was significantly improved in the hydrolysis step: when operating at higher S/L (0.4), the hydrolysis efficiency was twice the one achieved by using a bioreactor with a Rushton stirrer.
NeuroStylist (2017)

Nowadays, as a beauty-enhancing product, clothing plays an important role in human's social life. In fact, the key to a proper outfit usually lies in the harmonious clothing matching. Nevertheless, not everyone is good at clothing matching. Fortunately, with the proliferation of fashion-oriented online communities, fashion experts can publicly share their fashion tips by showcasing their outfit compositions, where each fashion item (e.g., a top or bottom) usually has an image and context metadata (e.g., title and category). Such rich fashion data offer us a new opportunity to investigate the code in clothing matching. However, challenges co-exist with opportunities. The first challenge lies in the complicated factors, such as color, material and shape, that affect the compatibility of fashion items. Second, as each fashion item involves multiple modalities (i.e., image and text), how to cope with the heterogeneous multi-modal data also poses a great challenge. Third, our pilot study shows that the composition relation between fashion items is rather sparse, which makes traditional matrix factorization methods not applicable. Towards this end, in this work, we propose a content-based neural scheme to model the compatibility between fashion items based on the Bayesian personalized ranking (BPR) framework. The scheme is able to jointly model the coherent relation between modalities of items and their implicit matching preference. Experiments verify the effectiveness of our scheme, and we deliver deep insights that can benefit future research.
The Last Photo (1998)

Longman Easystarts is a series of low level readers designed for students who are just starting to read and who want to read books which are simple but not childish. The stories are considered particularly suitable for students starting English at secondary school. The language level is pitched lower than Longman Structural Readers Stage 1 (which has a basic vocabulary of 300 words) and the structures, sentence length and vocabulary are carefully controlled. Each page of the book is made up of 2/3 of illustration and 1/3 of text, and the illustrations should facilitate and reinforce comprehension as well as making the books attractive to students. There are questions at the back, and an accompanying cassette is available which contains readings of all six stories in the series. The story of this book revolves around the time when Pam and Martin go sight-seeing in Cambridge. Martin tries to take a photo of Pam and accidentally photographs a man who is wanted by the police.
Sea-Level Changes (1988)

Sea-Level Changes: An Integrated Approach - In October 1985, SEPM sponsored a four-day conference entitled ?Sea-Level Changes ? An Integrated Approach.? The purpose of the conference was to provide a forum for an interdisciplinary exchange of ideas on sea-level changes and to provide an opportunity for integrating various types of evidence in approaching unresolved issues. The conference was successful in bringing together scientists from industry, academia, and government, representing all of the major geosciences disciplines. Presentations of many new papers, plus significant releases of data that were previously held proprietary, provided fertile ground for discussion. This much-cited volume represents the best of the material presented at the conference. Includes the early ?Vail? chart.
Rural value-orientations and farm-policy positions and actions (1968)

There is limited consensus within the agricultural sector of the United States concerning government farm policy. American farmers differ widely in their perceptions of the proper role of government in agriculture.\nIt is generally believed that value and belief differences among farmers are meaningfully associated with the variety of positions and actions taken by farmers with respect to government farm policy. Several observers have suggested that, if these value and belief diversities can be clearly articulated and resolved, more rapid progress can be made toward solving many present farm problems. However, there is little information on the relationship between values and beliefs and farm-policy positions and actions. Research concerning these relationships may be useful for assessing more precisely what role values and beliefs play in the present farm-policy conflict.
Some Potent Morphine Antagonists Possessing High Analgesic Activity<sup>1</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Potent Morphine Antagonists Possessing High Analgesic Activity1Marshall Gates and Thomas A. MontzkaCite this: J. Med. Chem. 1964, 7, 2, 127–131Publication Date (Print):March 1, 1964Publication History Published online1 May 2002Published inissue 1 March 1964https://pubs.acs.org/doi/10.1021/jm00332a002https://doi.org/10.1021/jm00332a002research-articleACS PublicationsRequest reuse permissionsArticle Views217Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biocompatibility testing of NiTi screws using immunohistochemistry on sections containing metallic implants (1996)

NiTi is one of the most innovative concepts to have appeared in the field of metallic biomaterials in recent years but its biocompatibility remains controversial. We evaluated the biocompatibility of Nitinol screws using immunohistochemistry to observe the distribution of bone proteins during bone remodeling process around NiTi implant. Results were compared with screws made of Vitallium, c.p. titanium, Duplex austenitic-ferritic stainless steel (SAF), and Stainless Steel 316L. Screws were implanted in rabbit tibia for 3, 6, and 12 weeks. Embedding was performed in the hard resin Technovit, and for the immunohistochemical procedure undecalcified sections with bone-anchored implants could thus be used. The immunostaining method developed seemed to be a reliable technique to stain proteins in undecalcified sections. Biocompatibility results of the NiTi screws compared with the other screws showed a slower osteogenesis process characterized by no close contact between implant and bone, disorganized migration of osteoblasts around the implant, and a lower activity of osteonectin synthesis.
Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly (2017)

Synapse assembly likely requires postsynaptic target recognition by incoming presynaptic afferents. Using newly generated conditional knock-in and knockout mice, we show in this study that latrophilin-2 (Lphn2), a cell-adhesion G protein-coupled receptor and presumptive α-latrotoxin receptor, controls the numbers of a specific subset of synapses in CA1-region hippocampal neurons, suggesting that Lphn2 acts as a synaptic target-recognition molecule. In cultured hippocampal neurons, Lphn2 maintained synapse numbers via a postsynaptic instead of a presynaptic mechanism, which was surprising given its presumptive role as an α-latrotoxin receptor. In CA1-region neurons in vivo, Lphn2 was specifically targeted to dendritic spines in the stratum lacunosum-moleculare, which form synapses with presynaptic entorhinal cortex afferents. In this study, postsynaptic deletion of Lphn2 selectively decreased spine numbers and impaired synaptic inputs from entorhinal but not Schaffer-collateral afferents. Behaviorally, loss of Lphn2 from the CA1 region increased spatial memory retention but decreased learning of sequential spatial memory tasks. Thus, Lphn2 appears to control synapse numbers in the entorhinal cortex/CA1 region circuit by acting as a domain-specific postsynaptic target-recognition molecule.
PEWs: a decentralized dynamic scheduler for ILP processing (2002)

This paper presents a new execution model called PEWs (Parallel Execution Windows). It performs decentralized dynamic scheduling by splitting the instruction window among multiple hardware execution windows that can all execute code in parallel. While splitting the instruction stream, dependent instructions are generally allocated to the same execution window. Speculative execution is carried out with the help of branch prediction; speedy recovery from incorrect speculative execution is effected with the help of decentralized recovery actions. Other novel features of the execution model include register file queues to enforce register dependencies. The paper also presents the simulation results, to date, of our attempts to study the PEWs execution model. The results indicate goal potential for this execution model.
Analysis of gemcitabine liposome injection by HPLC with evaporative light scattering detection (2012)

Gemcitabine liposome injection (i.e., stealth liposomes) has facilitated the targeting of gemcitabine for cancer treatment. We systemically reviewed liposome-based drug-delivery systems, which can improve pharmacokinetics, reduce side effects, and potentially increase tumor uptake, for pancreatic cancer therapy. A novel liposomal formulation, which allows for higher tumor-targeting efficiencies and can be used in current clinical trials to treat this challenging disease, has gained great popularity and attention. In this work, a simple, rapid high-performance liquid chromatography (HPLC) method was developed for the simultaneous determination of N-(carbonyl-methoxypolyethylene glycol 2000)-1, 2-distearoyl-sn-glycero-3-phosphoethanolamine sodium salt and neutral colipids cholesterol and hydrogenated soy phosphatidylcholine or distearoyl phosphatidylcholine. Because of the poor ultraviolet absorbance of the lipids, evaporative light-scattering detection (ELSD) was used to monitor the separation. The separation was carried out on a YMC-Pack column (YMC Co., Ltd., Kyoto, Japan). Lipids were eluted using binary linear gradients starting from a mixture of 80% A and 20% B to 100% B in 10 minutes, followed by a 6-minute plateau at 100% B, where A is chloroform/isopropyl alcohol/diethylamine/trifluoroacetic acid (TFA) (50:50:0.01:0.0025) and B is chloroform/isopropyl alcohol/H₂O/diethylamine/TFA (41:50:9:0.01:0.0025). The mobile phase composition was then changed back to initial solvent mixture in 1 minute, and the column was equilibrated for 13 minutes before every subsequent run. Then, 0.025% (v/v) TFA was added into the mobile phase to enhance the retaining of the stealth lipids. This newly developed method enabled direct analysis of liposomes without solvent lipid extraction and was validated to be linear, precise, accurate, specific, and sensitive. The method has been successfully employed in a wide range of lipid-based formulation screening, process development, and stability testing. Further, we describe the simple, rapid HPLC-ELSD method for the simultaneous determination of all the lipids and active pharmaceutical ingredients in various liposome-based drug formulations. The method can quantitate all the lipids of active targeting liposomes, which bond with folic acid.
Analysis and optimization of accumulation-mode varactor for RF ICs (2002)

This paper presents a novel RF IC varactor implemented in a standard CMOS process. This device has shown a remarkable tuning range of 150%, sensitivity of 300%/V, and quality factor of 23 at 1 GHz. A physical model of the varactor is presented and confirmed with measured data. Using the model derived, optimization has shown that a Q as high as 200 can be achieved.
Differential Ion Mobility Separations in the Low-Pressure Regime (2017)

Ion mobility spectrometry (IMS) in conjunction with mass spectrometry (MS) has emerged as a powerful platform for biological and environmental analyses. An inherent advantage of differential or field asymmetric waveform IMS (FAIMS) based on the derivative of mobility vs electric field over linear IMS based on absolute mobility is much greater orthogonality to MS. Effective coupling of linear IMS to MS and diverse IMS/MS arrangements and modalities impossible at ambient buffer gas pressure were enabled at much reduced pressures. In contrast, FAIMS devices operate at or near atmospheric pressure, which complicated integration with MS. Here, we show FAIMS at ∼15-30 Torr using a planar-gap stage within the MS instrument envelope. Fields up to ∼300 Td permitted by the Paschen law at these pressures greatly raise the separation speed, providing fair resolution in ∼10 ms and FAIMS scans in under 5 s. Rapid separation and efficient ion collection at low pressure minimize losses in the FAIMS step. Separations for key analyte classes and their dependences on electric field mirror those at ambient pressure. The potential for proteomics is demonstrated by separations of isomeric peptides with variant localization of post-translational modifications.
Influence of Cellular and Molecular Factors on Membrane Target Sensitivity to Insecticides (2017)

The effective control of insect pests is based on the use of insecticides. Most of these compounds act on molecular targets in the insect nervous system. However, the largescale deployment of insecticide treatment has led to the development of resistance, which decreases insecticide efficacy. Although the resistance mechanisms are largely studied today, this review aims to point out new insights on the less-known cellular and molecular factors involved in the modulation of the sensitivity of the targets to insecticides. This review will focus on the phosphorylation/dephosphorylation process, the post-transcriptional events such as editing and alternative splicing and the influence of the association with auxiliary proteins of the receptors and/or ion channels targeted by insecticides. In addition, the involvement of calcium-dependent signaling pathways in the modulation of the sensitivity of the target to insecticides will also be considered and discussed. Finally, this review will insist on different strategies proposed to optimize the efficacy of insecticide treatment while reducing doses to decrease side effects on environment and on non-target organisms by combining two different chemical insecticides or a given active ingredient associated with biological and/or chemical synergistic agents. This review is part of the special issue "Insecticide Mode of Action: From Insect to Mammalian Toxicity".
ChemInform Abstract: IMPROVED HIGH‐PURITY ARC‐FURNACE SILICON FOR SOLAR CELLS (1985)

Abstract Durch Reduktion von SiO 2 mit Kohle im 100 kW Lichtbogenofen dargestelltes Si besitzt eine B‐Verunreinigung von 1.8 ppma.
Ion Irradiation Effect on Ba<sub>2</sub>YCu<sub>3</sub>O<sub>7</sub> Superconductor (1989)

Single-phased Ba 2 YCu 3 O 7- y pellets were sequentially irradiated with 200 keV oxygen or nitrogen ions up to 1.5×10 16 m -2 at room temperature, and electrical resistance was measured as a function of temperature. The superconducting transition temperature measured with current density greater than 30 kA·m -2 was increased by the ion irradiations to about 3×10 15 m -2 . The zero-resistance temperature measured with 121 kA·m -2 in current density was enhanced from 88.1–89.1 K to 90.4 K by oxygen ion irradiation to 1.6×10 15 m -2 , and then reduced to a level obtained in the nonirradiated condition after irradiation to about 1×10 16 m -2 .