gebhart/patrepeval huggingface dataset:
Construcción de un muelle de carga de sal en La Mata a fines del siglo XVlI (1998)

Las salinas de La Mata fueron un lugar de exportacion de sal desde
la Antiguedad. Para poder sacarla hacia necesaria la existencia de un
muelle de carga. La fragilidad de este y los temporales provocaron,
sistematicamente, su destruccion. En 1694, se instruyo un expediente
para levantar, otra vez, el muelle. Se plantearon dos opciones: hacerlo
de piedra o de madera. Se decidio levantar el segundo por su rapidez y
menor costo. Es un expediente interesante porque ademas de reunir las
alegaciones de los expertos, incluye los capitulos, condiciones de los
dos proyectos y un plano del de piedra.
Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis (2014)

Chemokine receptors on leukocytes mediate the recruitment and accumulation of these cells within affected joints in chronic inflammatory diseases such as rheumatoid arthritis (RA). Identification of involved receptors offers potential for development of therapeutic interventions. The objective of this study was to investigate the expression of orphan receptor GPR15/BOB in the synovium of RA and non-RA patients and in peripheral blood of RA patients and healthy donors. GPR15/BOB protein and messenger RNA expression were examined in RA and non-RA synovium by immunofluorescence and reverse-transcription polymerase chain reaction (RT-PCR) respectively. GPR15/BOB expression on peripheral blood leukocytes was analysed by flow cytometry and GPR15/BOB messenger RNA was examined in peripheral blood monocytes by RT-PCR. GPR15/BOB protein was observed in CD68+ and CD14+ macrophages in synovia, with greater expression in RA synovia. GPR15/BOB protein was expressed in all patient synovia whereas in non-RA synovia expression was low or absent. Similarly GPR15/BOB messenger RNA was detected in all RA and a minority of non-RA synovia. GPR15/BOB protein was expressed on peripheral blood leukocytes from RA and healthy individuals with increased expression by monocytes and neutrophils in RA. GPR15/BOB messenger RNA expression was confirmed in peripheral blood monocytes. In conclusion GPR15/BOB is expressed by macrophages in synovial tissue and on monocytes and neutrophils in peripheral blood, and expression is up-regulated in RA patients compared to non-RA controls. This orphan receptor on monocytes/macrophages and neutrophils may play a role in RA pathophysiology.
DIFtree: a software package for the analysis of dynamic fault tree models (2002)

Several advances in fault tree models have been developed as an aid in the analysis of computer systems. Such advances include the ability to model sequence dependencies, the application of fault trees to the analysis of hardware and software fault tolerant systems, the ability to include details of the recovery process in the fault tree solution, and the use of modularization and binary decision diagrams as an aid in solution. In this paper we present a software package (DIFtree) that implements these advances into a single methodology that can solve both dynamic and static fault trees, and which is applicable to the analysis of hardware, software and humanware in complex computer-based systems.
Phosphorylation of CorS and CorR, regulatory proteins that modulate production of the phytotoxin coronatine in Pseudomonas syringae (2000)

Production of the phytotoxin coronatine (COR) in Pseudomonas syringae pv.glycinea PG4180 is controlled by a modified twocomponent regulatory system consisting of three genes, corR, corP, and corS.CorR and CorP show similarity to response regulators, and CorS is related to histidine protein kinases that function as environmental sensors.In this study, CorR, CorP and the cytoplasmic portion of CorS, designated CorSv, were overproduced in P. syringae as translational fusions to the maltose-binding protein and purified by affinity chromatography.Autophosphorylation of CorSv was demonstrated when [Q-32 P]ATP was used as a phosphodonor.Phosphorylated CorSv (CorSvVP) was stable under basic conditions, but extremely sensitive when the pH was reduced, which is consistent with phosphorylation at a histidine residue.CorSvVP transferred its phosphoryl group to CorR but not to CorP, which correlates with the presence of a receiver aspartate residue in the former but not the latter protein.These results indicate that CorS functions as a histidine protein kinase and transphosphorylates CorR, a positive activator of cor gene transcription.
Tuning the Moisture and Thermal Stability of Metal–Organic Frameworks through Incorporation of Pendant Hydrophobic Groups (2013)

An isostructural series of NbO-type porous metal–organic frameworks (MOFs) with different dialkoxy-substituents of formula Cu2(TPTC-OR) (TPTC-OR = 2′,5′-di{alkyl}oxy-[1,1′:4′,1″-terphenyl]-3,3″,5,5″-tetracarboxylate, R = Me, Et, nPr, nHex) has been synthesized and characterized. The moisture stability of the materials has been evaluated, and a new superhydrophobic porous MOF has been identified. The relationship between pendant side chain length and thermal stability has been analyzed by in situ synchrotron powder X-ray diffraction, showing decreased thermal stability as the side chain length is increased, contradictory to thermogravimetric decomposition studies. Additionally, the four materials exhibit moderate Brunauer–Emmett–Teller (BET) and Langmuir surface areas (1127–1396 m2 g–1 and 1414–1658 m2 g–1) and H2 capacity up to 1.9 wt % at 77 K and 1 bar.
Medial patella-femoral ligament reconstruction using the anterior half of the peroneus longus tendon as a combined procedure for recurrent patellar instability (2016)

Level IV, case series.
Cytolysins, Superantigens, and Pneumonia Due to Community‐Associated Methicillin‐Resistant<i>Staphylococcus aureus</i> (2009)

This editorial evaluates data in an accompanying manuscript by Hongo et al. and includes comparison to other published data on virulence factors (cytolysins and superantigens) associated with or contributing to severe pulmonary diseases caused by methicillin-resistant Staphylococcus aureus (MRSA). The major conclusion of the Hongo et al. article is that studies to assess cytolysin functions in serious human MRSA infections must use non-murine models, since cytolysins, such as Panton-Valentine leukocidin (PVL), have limited activity in killing mouse polymorphonuclear leukocytes (PMNs), compared to killing human PMNs.
Carbon dioxide generation rates for building occupants (2017)

Indoor carbon dioxide (CO<sub>2</sub> ) concentrations have been used for decades to characterize building ventilation and indoor air quality. Many of these applications require rates of CO<sub>2</sub> generation from the building occupants, which are currently based on approaches and data that are several decades old. However, CO<sub>2</sub> generation rates can be derived from well-established concepts within the fields of human metabolism and exercise physiology, which relate these rates to body size and composition, diet, and level of physical activity. This paper reviews how CO<sub>2</sub> generation rates have been estimated in the past and discusses how they can be characterized more accurately. Based on this information, a new approach to estimating CO<sub>2</sub> generation rates is presented, which is based on the described concepts from the fields of human metabolism and exercise physiology. Using this approach and more recent data on body mass and physical activity, values of CO<sub>2</sub> generation rates from building occupants are presented along with the variability that may occur based on body mass and activity data.
A Data Cleaning Method Based on Association Rules (2007)

The quality of the data affects the usability of the data mining's results. Making a data preparation before the mining can improve the quality. If the data are collected from the multi-data source, data preparation becomes very difficult. In this paper, a data-cleaning method based on the association rules is proposed. The new method adjusts the basic business rules provided by the experts with association rules mined from multi-data sources, and generates the advanced business rules for every data source. Using this method, time is saved and the accuracy of the data cleaning is improved.
The role of impedance monitoring in patients with extraesophageal symptoms (2013)

2b.
Prediction of laser-induced thermal damage with artificial neural networks (2019)

Abstract Laser-induced thermotherapy (LITT) has been widely studied since it is a minimally invasive technique for focal destruction of liver tumors without side effects. However, there are still some concerns about the treatment and monitoring thermal effects during operation. Although real-time imaging modalities are available, like magnetic resonance imaging, they are not cost-effective and not applicable to all conditions. This paper presents artificial neural network (ANN) modeling of laser-induced thermal damages on ex vivo liver tissue. In this work three laser sources, i.e. a diode pumped laser with a wavelength of 980 nm, a 1070 nm yttrium lithium fluoride fiber laser, and a 1940 nm thulium fiber laser, were used in order to thermally damage tissues by applying the laser until coagulation observed. The diameter and depth of coagulation were empirically measured and used to train the ANN model by finding the correlation between laser parameters (application time, power, penetration depth, wavelength, and spot size) and thermal damages. Thermal damage can be determined by observing coagulation diameter and coagulation depth. The prediction ability and accuracy of the trained ANN model were tested by comparing the actual and simulated results. Our result showed that the ANN successfully predicts LITT damage in terms of coagulation diameter and coagulation depth, with a very high accuracy. The trained ANN model was compared with two mathematical models. In terms of performance, the ANN is a very useful and practical tool for determining LITT damage.
Advanced ESD power clamp design for SOI FinFET CMOS technology (2010)

Two novel ESD power clamp design techniques for SOI FinFET CMOS technology are reported. First, a layout improvement technique is discussed for stacked gated diodes, which reduces the required area for a given ESD robustness and at the same time reduces the on-resistance of the clamp. Secondly, circuit design techniques are used to convert a standard RC-triggered active ESD clamp into a bi-directional design, thereby alleviating the need for a separate reverse protection diode. The concepts can be applied for planar SOI as well.
Protecting sub-Antarctica via the world heritage convention: Recommendations for improved domestic and transboundary governance in Australasia (2013)

This article critiques the role of the World Heritage Convention in the protection of sub-Antarctica, specifically the three listed sites under the Convention: Heard Island and the McDonald Islands, Macquarie Island, and the New Zealand Subantarctic Islands. Major issues of concern are outlined, legal obligations of the Convention and other international law are explained, and domestic implementation by law, policy, planning and management is analysed. Specific attention is given to questions of transboundary governance, in particular challenges presented by federalism in Australia (Macquarie), links between Macquarie Island and the New Zealand Subantarctic Islands, and the relationship between Heard Island and the McDonald Islands and the neighbouring (currently not listed) French sub-Antarctic island, Kerguelen, which call for further cooperation.
<i>N</i>‐acetylcysteine prevents β‐amyloid toxicity by a stimulatory effect on p35/cyclin‐dependent kinase 5 activity in cultured cortical neurons (2008)

Although previous studies have indicated that the neuroprotective effect of N-acetylcysteine (NAC) required activation of the Ras-extracellular-signal-regulated kinase (ERK) pathway, the detailed mechanisms and signal cascades leading to activation ERK are not clear. In the present study, we investigated the effect of NAC on A beta(25-35)-induced neuronal death. Pretreatment of neurons with NAC 1 hr before application of A beta prevented A beta-mediated cell death. NAC increased cyclin-dependent kinase 5 (Cdk5) phosphorylation, an effect that was blocked by Cdk5 inhibitor. The neuroprotective effect of NAC was significantly attenuated by Cdk5 inhibitors or in neurons transfected with Cdk5 or p35 small interfering RNA (siRNA). Conversely, pretreatment of neurons with the calpain inhibitors calpeptin or MDL28170 enhanced the neuroprotective effect of NAC. A beta(25-35) caused a significant decrease in the level of p35, with a concomitant increase in p25, which was completely prevented by NAC. This effect of NAC was blocked by the Cdk5 inhibitors roscovitine and butyrolactone. In addition, NAC increased Cdk5/p35 kinase activity but reduced Cdk5 kinase activity. A beta(25-35) treatment decreased phosphorylated levels of ERK, which could be reversed by NAC. The effect of NAC was completely blocked by Cdk5 inhibitors. NAC reversed the A beta(25-35)-induced decrease in the expression of Bcl-2, which could be blocked by the MAPK kinase (MEK) inhibitor or Cdk5 inhibitors. These results suggest that NAC-mediated neuroprotection against A beta toxicity is likely mediated by the p35/Cdk5-ERKs-Bcl-2 signal pathway.
Charge-Reversal APTES-Modified Mesoporous Silica Nanoparticles with High Drug Loading and Release Controllability (2016)

In this study, we demonstrate a facile strategy (DL-SF) for developing MSN-based nanosystems through drug loading (DL, using doxorubicin as a model drug) followed by surface functionalization (SF) of mesoporous silica nanoparticles (MSNs) via aqueous (3-aminopropyl)triethoxysilane (APTES) silylation. For comparison, a reverse functionalization process (i.e., SF-DL) was also studied. The pre-DL process allows for an efficient encapsulation (encapsulation efficiency of ∼75%) of an anticancer drug [doxorubicin (DOX)] inside MSNs, and post-SF allows in situ formation of an APTES outer layer to restrict DOX leakage under physiological conditions. This method makes it possible to tune the DOX release rate by increasing the APTES decoration density through variation of the APTES concentration. However, the SF-DL approach results in a rapid decrease in drug loading capacity with an increase in APTES concentration because of the formation of the APTES outer layer hampers the inner permeability of the DOX drug, resulting in a burst release similar to that of undecorated MSNs. The resulting DOX-loaded DL-SF MSNs present a slightly negatively charged surface under physiological conditions and become positively charged in and extracellular microenvironment of solid tumor due to the protonation effect under acidic conditions. These merits aid their maintenance of long-term stability in blood circulation, high cellular uptake by a kind of skin carcinoma cells, and an enhanced intracellular drug release behavior, showing their potential in the delivery of many drugs beyond anticancer chemotherapeutics.
Expert Clinical Interface (2002)

We present a process-driven approach that is embedded in the design of a clinical system for patient management in cardiology. It integrates elements of expert systems, multimedia, object-oriented manipulation, instrumentation interfaces and medical telematics into a human-computer interface presentation for making clinical decisions. The Expert Clinical Interface (ECI) is a front-end to our development of a new generation, intelligent clinical system that interacts with the physician in a manner that is in congruence with the diagnosis-therapy process, and that aids in coronary care management. The paper describes the functional requirements for a cardiology workstation, the ECI interface, the data model and architecture, the decision-support system, and the frame-based language used to encode the diagnosis-therapy process.
Sphenopalatine Ganglion Block for the Treatment of Acute Migraine Headache (2018)

Transnasal sphenopalatine ganglion block is emerging as is an attractive and effective treatment modality for acute migraine headaches, cluster headache, trigeminal neuralgia, and several other conditions. We assessed the efficacy and safety of this treatment using the Sphenocath® device. 55 patients with acute migraine headaches underwent this procedure, receiving 2 ml of 2% lidocaine in each nostril. Pain numeric rating scale (baseline, 15 minutes, 2 hours, and 24 hours) and patient global impression of change (2 hours and 24 hours after treatment) were recorded. The majority of patients became headache-free at 15 minutes, 2 hours, and 24 hours after procedure (70.9%, 78.2%, and 70.4%, resp.). The rate of headache relief (50% or more reduction in headache intensity) was 27.3% at 15 minutes, 20% at 2 hours, and 22.2% at 24 hours. The mean pain numeric rating scale decreased significantly at 15 minutes, 2 hours, and 24 hours, respectively. Most patients rated the results as very good or good. The procedure was well-tolerated with few adverse events. This treatment is emerging as an effective and safe option for management of acute migraine attacks.
WAVEGUIDE: Evaluating SPARQL Property Path Queries (2015)

The extension of SPARQL 1.1 of property paths now o↵ers a type of regular path query for RDF graph databases. While eminently useful, these queries are dicult to optimize to evaluate eciently. We have embarked on a project we call Waveguide to build a cost-based optimizer for SPARQL queries with property paths. Waveguide maps the property path to a waveguide plan (WGP )c omposed ofwavefront automata (WFAs) modeled by (non-deterministic) finite automata. The waveguide plan guides the graph search during evaluation. Our Waveguide prototype illustrates the types of optimizations this approach a↵ords and the performance gains that can be obtained.
Research advance of microRNA in HIV-1 infection and related diseases (2019)

MicroRNA (miRNA) is an important post-transcriptional gene expression regulator, and its expression profile changes are related to many human pathology. The correlation between miRNA and human immunodeficiency virus 1 (HIV-1) has become one of the hot spots in global research. In this paper, the effects of miRNA on the transcription replication and latent infection of HIV-1 virus, the study of miRNA in HIV-1 related diseases and the therapeutic prospects of AIDS are reviewed.


Key words: 
microRNA; HIV-1; Virus replication; Latent infection; Therapy
Optical-Mode Demultiplexing by Optical MIMO Filtering of Spatial Samples (2012)

An optical spatial-mode demultiplexer is proposed consisting of an optical sampler taking probes from the aperture of the multimode fiber, which are then launched into an optical multiple-input multiple-output (MIMO) filter. A theoretical analysis of coupler matrices of three sampler options reveals that samplers can be characterized by a mode-dependent sampling loss and sampling crosstalk arising from a lacking orthogonality of sampling vectors of different modes. The theoretical optimum MIMO allpass filter can be realized by a waveguide structure consisting of cascaded and in parallel operating directional couplers. The multiplexer is scalable to higher mode numbers due to the absence of splitting loss.
A 5.2-Gb/s Low-Swing Voltage-Mode Transmitter With an AC-/DC-Coupled Equalizer and a Voltage Offset Generator (2013)

This paper describes a voltage-mode transmitter with an AC-/DC-coupled equalizer. A dual-loop regulator controls the tap-weight coefficient for the DC-coupled equalizer while maintaining the output matching condition. An AC-coupling technique is employed to enhance the edge rate and reduce the burden of the DC-coupled equalizer. The transmitter also supports the ability to add a DC differential voltage offset into the output signal so that the voltage margin of the link can be measured. The transmitter was fabricated using a 0.13-um CMOS technology. When 240- mV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">PP</sub> , 5.2-Gb/s data are sent over 20-inch FR4 channels, the eye of the received data has a voltage margin of 60 mV and a peak-to-peak jitter of 40 ps. The proposed transmitter consumes 5.86 mW from a 1.2-V supply while operating at 5.2 Gb/s.
Specialized Role for a Murine Class I-b MHC Molecule in Prokaryotic Host Defenses (1992)

Although nonclassical (class I-b) gene products represent the majority of murine major histocompatibility complex (MHC) genes, the role of these relatively nonpolymorphic molecules remains uncertain. Recently, one such protein, H-2M3 (formerly designated Hmt), was shown to bind and specifically present N-formylated peptides to cytotoxic T lymphocytes. Because N-formylation is characteristic of prokaryotic proteins, this MHC molecule may be especially adapted for a role in the mammalian defense against bacterial attack. The current studies demonstrate that an MHC molecule, indistinguishable from H-2M3, presents antigens derived from the intracellular pathogen Listeria monocytogenes to Listeria-specific CD8+ cells.
Characterization of the Photoperiodic Response of Post-flowering Development in Maturity Isolines of Soyabean [Glycine max(L.) Merrill] 'Clark' (1998)

Plants of all eight isolines of three maturity genes (all combinations of two alleles at the three loci E1 / e1 , E2 / e2 , E3 / e3 ) of soyabean [ Glycine max (L.) Merrill] were grown in four different photoperiods (12, 13, 14 or 15 h d −1 ) at 30/24 °C from first flower opening to harvest maturity. Photoperiod, isoline, and their interaction, affected significantly ( P <0.01) the duration between first and last flowering, and reproductive duration. The interactions between genotype and photoperiod were sufficiently strong that considerable differences in these durations were detected among isolines in the least-inductive environment (15 h d −1 ) whereas differences were negligible in the most-inductive regime (12 h d −1 ). There was a negative linear relation between photoperiod and both rate of progress from the appearance of the first to the last flower, and rate of progress from first flowering to harvest maturity; sensitivity to photoperiod varied ( P <0.05) six- and five-fold, respectively, among the extreme isolines ( e1e2e3 and E1E2E3 ). The three dominant alleles E1 , E2 and E3 , singly, had comparatively little effect on post-flowering traits, but considerable epistasis (particularly between E1 and E2 ) was detected for sensitivity to photoperiod in respect of rates of progress from the appearance of the first to the last flower, and from first flower to harvest maturity. Thus the large variations detected for these traits are the consequence of gene×gene (×gene)×environment interactions. Copyright 1998 Annals of Botany Company.