gebhart/patrepeval huggingface dataset:
Automated Data Slicing for Model Validation: A Big Data - AI Integration Approach (2019)

As machine learning systems become democratized, it becomes increasingly important to help users easily debug their models. However, current data tools are still primitive when it comes to helping users trace model performance problems all the way to the data. We focus on the particular problem of slicing data to identify subsets of the validation data where the model performs poorly. This is an important problem in model validation because the overall model performance can fail to reflect that of the smaller subsets, and slicing allows users to analyze the model performance on a more granular-level. Unlike general techniques (e.g., clustering) that can find arbitrary slices, our goal is to find interpretable slices (which are easier to take action compared to arbitrary subsets) that are problematic and large. We propose SliceFinder, which is an interactive framework for identifying such slices using statistical techniques. Applications include diagnosing model fairness and fraud detection, where identifying slices that are interpretable to humans is crucial. This research is part of a larger trend of Big data and Artificial Intelligence (AI) integration and opens many opportunities for new research.
<i>O</i>-Methylated and sulfoconjugated catecholamines: differential activities at human platelet α<sub>2</sub>-adrenoceptors (1991)

The physiological effects of the sulfoconjugates of epinephrine, norepinephrine, and the 3-O-methylated catecholamines, metanephrine, normetanephrine, and methoxytyramine were examined with regard to their alpha 2-adrenoceptor binding properties and aggregation activity in human platelets. Sulfoconjugation of catecholamines resulted in the loss of both their competitive potency for [3H]yohimbine binding and their influence on platelet aggregation. O-Methyl substituted catecholamines showed attenuation of their alpha 2-adrenoceptor binding affinities when compared with those of the corresponding non-esterified amines. Unlike the free amine epinephrine, which stimulated platelet aggregation, the O-methylated catecholamine derivatives inhibited aggregation. Inhibition was dose-dependent and restricted to the alpha 2-adrenoceptor mediated aggregation response stimulated by epinephrine (1 microM) or potentiated by subthreshold concentrations of epinephrine (30-300 nM) in the presence of subaggregatory doses of vasopressin (10-30 nM). Collagen- and ADP-induced platelet aggregation was not affected. The hydrophilic beta-antagonist CGP 12177 displayed no effects. However, high concentrations (0.1 mM) of both isomers of the strongly lipophilic beta-adrenoceptor antagonist propranolol inhibited the actions of all aggregators by stabilizing the membrane. Such a nonspecific membrane interaction of the methylated catecholamines could be excluded because of their low lipid solubility calculated in a n-octanol-phosphate buffer system at pH 7.4. We suggest therefore that methylated catecholamines are biological alpha 2-adrenoceptor antagonists acting on alpha 2-adrenoceptor stimulated reactions of human platelets. Whether this receptor antagonism is relevant to other human tissues needs clarification. Sulfated catecholamines, however, are wholly ineffective at this receptor site and may constitute a pathway to control the concentration of the active free catecholamines.
Beyond Minutiae: A Fingerprint Individuality Model with Pattern, Ridge and Pore Features (2009)

Fingerprints are considered to be unique because they contain various distinctive features, including minutiae, ridges, pores, etc. Some attempts have been made to model the minutiae in order to get a quantitative measure for uniqueness or individuality of fingerprints. However, these models do not fully exploit information contained in non-minutiae features that is utilized for matching fingerprints in practice. We propose an individuality model that incorporates all three levels of fingerprint features: pattern or class type (Level 1), minutiae and ridges (Level 2), and pores (Level 3). Correlations among these features and their distributions are also taken into account in our model. Experimental results show that the theoretical estimates of fingerprint individuality using our model consistently follow the empirical values based on the public domain NIST-4 database.
Vascular Remodeling after Spinal Cord Injury (2003)

In summary, femoral artery diameter and maximal hyperemic blood flow response per unit muscle volume are not different between SCI and AB individuals. Vascular atrophy after SCI appears to be closely linked to muscle atrophy. Furthermore, the SCI compared with AB individuals had a prolonged time to recovery, which may suggest decreased vessel reactivity.
RELIABILITY METHODS FOR SHIP STRUCTURES (1985)

ABSTRACT The ever increasing use of high‐strength materials and advanced technologies in surface ship structural design requires a very careful and systematic analysis to insure that levels of safety are maintained. This is much more easily said than done. The application of new technologies will not allow extrapolation of existing design criteria. Due to the uncertainties involved with future loading conditions, material properties, quality of workmanship in construction, and the limitations in numerical methods of analysis, the absolute safety of a structure cannot be established. It would therefore seem appropriate to use methods of analysis which would attempt to account for the various uncertainties and which allow the designer to limit the risk of unacceptable consequences. Estimation of this risk, even if used only to compare design alternatives, can be a useful and economical tool. Structural reliability has its roots in the fields of civil and aerospace engineering and has made great strides forward in the last decade. Many methods have been proposed to evaluate the risk of structural failure. These methods include: first order second moment (FOSM), advanced second moment (ASM), and Monte Carlo simulation using both conditional expectation and antithetic variates techniques for variance reduction. All of these methods consider the type of the problem, the various parameters involved, and the uncertainties associated with these parameters. In estimating the risk, the uncertainties are modeled as random variables with mean values, variance, and probability density and distribution functions. Each method uses this information in a different manner, involving some assumptions and limitations. In this paper we evaluate the available methods as to their suitability for estimating the risk of structural failure in ships. The merits and shortcomings of each method are discussed and each is then used to solve a simple example problem. The most effective method is chosen for more advanced work in this field.
Single pass diafiltration integrated into a fully continuous mAb purification process (2018)

Abstract The concept of continuous manufacturing has gained significant interest from the biopharmaceutical industry over the past several years. Benefits include increased manufacturing productivity, improved quality control, reduction in plant footprint, and more flexible management of facility capacity. There are several technologies currently available that enable continuous processing for chromatography and ultrafiltration. However, a single pass diafiltration design that meets the required small molecule clearance and has been integrated into a fully continuous monoclonal antibody purification process has not been previously published. Here, the theory and design of a 3‐stage single pass diafiltration step is presented. Buffer exchange greater than 99.75% was experimentally demonstrated. Several critical design aspects were incorporated to minimize system complexity and reduce the buffer volume requirements. Lastly, single pass diafiltration was demonstrated in a pilot scale continuous process with uninterrupted flow from the bioreactor through the formulation step. This work illustrates the feasibility of incorporating a single pass diafiltration step into an end‐to‐end continuous protein purification process.
Immunohistochemical localization of peripheral nitric oxide synthase‐containing nerves using antibodies raised against synthesized C‐ and N‐terminal fragments of a cloned enzyme from rat brain (1993)

Antibodies were raised in rabbits against C- or N-terminal fragments of a cloned nitric oxide synthase (NOS) enzyme from rat cerebellum, and used for demonstration of NOS-immunoreactive (NOS-IR) nerves in different tissues from the rat (colon, duodenum, adrenal gland, aorta, caval vein, penis and urethra). Both antisera demonstrated the same neuronal elements, although with differences in intensity in the immunoreaction in some tissues. Sections incubated with antisera preabsorbed with excess of the antigens showed no NOS immunoreactivity. In duodenum and colon, NOS-immunoreactivity was found in the cytoplasm of numerous cell bodies in myenteric ganglia and in some nerve cell bodies in the submucosa. NOS-IR nerve fibres were numerous in the circular muscle layer, while few were found in the longitudinal layer or the mucosa and submucosa. In the penis, strong NOS immunoreactivity was found in nerves surrounding the deep penile and dorsal arteries, and in nerves in the stroma of the cavernous tissue. In the urethra, NOS immunoreactivity was found in nerves in the mucosa. No NOS immunoreactivity was found in the urothelium. The adrenal medulla, and occasionally the cortex, contained nerve cell bodies with strong cytoplasmic NOS immunoreactivity as well as scattered nerve fibres. No NOS immunoreactivity was found in the abdominal aorta or inferior caval vein. Combined NOS immunostaining and NADPH diaphorase staining showed that virtually all NOS-IR nerve structures were also NADPH diaphorase-positive. However, thin nerve fibres and cell linings were sometimes better visualized by NOS-immunohistochemistry. Furthermore, the adrenal cortex, which only occasionally showed NOS immunoreactivity, was strongly NADPH diaphorase-positive.(ABSTRACT TRUNCATED AT 250 WORDS)
Carbocyclic analogs of nucleosides. Part 2.. Synthesis of 2′,3′‐dideoxy‐5′‐homonucleoside analogs (1992)

Abstract A set of derivatives of cyclopentaneacetic acid cis ‐substituted at position 3 by nucleoside bases (both purines and pyrimidines) were prepared and characterized (see 11, 14 , and 23a, b; Schemes 2–4 ). These molecules are carbocyclic analogs of 2′,3′‐dideoxy‐5′‐homonucleosides. In this synthesis, the skeleton was constructed from norbornanone and a novel method based on Mitsunobu chemistry used for the introduction of nucleoside‐base substituents. The scope of this method was further explored via the preparation of a cyclobutyl analog of dideoxyguanosine (see 17 , Scheme 3 ).
Heavy water: a distinctive and essential component of CANDU (1994)

The exceptional properties of heavy water as a neutron moderator provide one of the distinctive features of CANDU reactors. Although most of the chemical and physical properties of deuterium and protium (mass 1 hydrogen) are appreciably different, the low terrestrial abundance of deuterium makes the separation of heavy water a relatively costly process, and so of considerable importance to the CANDU system. World heavy-water supplies are currently provided by the Girdler-Sulphide process or processes based on ammonia-hydrogen exchange. Due to cost and hazard considerations, new processes will be required for the production of heavy water in and beyond the next decade. Through AECL`s development and refinement of wetproofed catalysts for the exchange of hydrogen isotopes between water and hydrogen, a family of new processes is expected to be deployed. Two monothermal processes, CECE (Combined Electrolysis and Catalytic Exchange, using water-to-hydrogen conversion by electrolysis) and CIRCE (Combined Industrially Reformed hydrogen and Catalytic Exchange, based on steam reforming of hydrocarbons), are furthest advanced. Besides its use for heavy-water production, the CECE process is a highly effective technology for heavy-water upgrading and for tritium separation from heavy (or light) water. (author). 10 refs., 1 tab., 7 figs.
Electric field stimulation of excitable tissue (1998)

The authors consider the determination of conditions when an excitable membrane can be considered linear and steady-state. The following topics are dealt with: threshold for a space-clamped fiber; threshold for a fiber stimulated by a point current source; subthreshold response; passive vs. active response; defibrillation stimulus-response time-constant; the transient intracellular current; the transient transmembrane potential due to junctional resistance.
Neuroprotection mediated by changes in the endothelial actin cytoskeleton (2000)

Cerebral blood flow is regulated by endothelium-derived nitric oxide (NO), and endothelial NO synthase–deficient (eNOS-deficient; eNOS(–/–)) mice develop larger cerebral infarctions following middle cerebral artery (MCA) occlusion. We report that disruption of Rho-mediated endothelial actin cytoskeleton leads to the upregulation of eNOS expression and reduces the severity of cerebral ischemia following MCA occlusion. Mice treated with the Rho inhibitor Clostridium botulinum C3 transferase (10 μg/d) or the actin cytoskeleton disrupter cytochalasin D (1 mg/kg) showed a two- to fourfold increase in vascular eNOS expression and activity. This increase in eNOS expression was not due to increases in eNOS gene transcription, but to prolongation of eNOS mRNA half-life from 10 ± 3 hours to 24 ± 4 hours. Indeed, endothelial cells overexpressing a dominant-negative Rho mutant (N19RhoA) exhibited decreased actin stress fiber formation and increased eNOS expression. Inhibition of vascular Rho guanosine-5′-triphosphate binding activity by the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor simvastatin increased cerebral blood flow to ischemic regions of the brain, and mice treated with simvastatin, C3 transferase, or cytochalasin D showed smaller cerebral infarctions following MCA occlusion. No neuroprotection was observed with these agents in eNOS(–/–) mice. These findings suggest that therapies which target the endothelial actin cytoskeleton may have beneficial effects in ischemic stroke.
Interleukin-9: A T-Cell Growth Factor with a Potential Oncogenic Activity (1993)

(1993). Interleukin-9: A T-Cell Growth Factor with a Potential Oncogenic Activity. Cancer Investigation: Vol. 11, No. 5, pp. 635-640.
Nitrogen-Regulated Hypermutator Strain of <i>Synechococcus</i> sp. for Use in In Vivo Artificial Evolution (2003)

Artificially evolved variants of proteins with roles in photosynthesis may be selected most conveniently by using a photosynthetic organism, such as a cyanobacterium, whose growth depends on the function of the target protein. However, the limited transformation efficiency of even the most transformable cyanobacteria wastes much of the diversity of mutant libraries of genes produced in vitro, impairing the coverage of sequence space. This highlights the advantages of an in vivo approach for generating diversity in the selection organism itself. We constructed two different hypermutator strains of Synechococcus sp. strain PCC 7942 by insertionally inactivating or nutritionally repressing the DNA mismatch repair gene, mutS. Inactivation of mutS greatly increases the mutation rate of the cyanobacterium's genes, leading to an up-to-300-fold increase in the frequency of resistance to the antibiotics rifampin and spectinomycin. In order to control the rate of mutation and to limit cellular damage resulting from prolonged hypermutation, we placed the uninterrupted mutS gene in the cyanobacterial chromosome under the transcriptional control of the cyanobacterial nirA promoter, which is repressed in the presence of NH(4)(+) as an N source and derepressed in its absence. By removing or adding this substrate, hypermutation was activated or repressed as required. As expected, hypermutation caused by repression in PnirA-mutS transformants led to an accumulation of spectinomycin resistance mutations during growth.
Revision of the underfrequency load-shedding scheme of the slovenian power system (2005)

The main motivation for the study presented in this paper was the numerous blackouts that occurred in 2003. After the Italian blackout, which almost caused a collapse of the Slovenian power system as well, it became clear that some automatic procedures, with underfrequency load-shedding being one of the most important ones, need to be thoroughly revised. In the first part of the paper we deal with the frequency dynamic model that was developed to simulate the impact of the most important system parameters on the frequency response after a major disturbance. Next, we determined the optimal number of load-shedding steps and the amount of load to be shed in each step. We also checked whether it is necessary to use the frequency decline gradient in the underfrequency relaying scheme, which is currently not implemented. The simulations were performed on a detailed model of the Slovenian power system using the software package EUROSTAG. The proposed underfrequency relays' settings conform to the UCTE Operation handbook.
THE INTERNATIONAL ADULT LITERACY SURVEY (IALS): UNDERSTANDING WHAT WAS MEASURED (2001)

ABSTRACT This paper offers a framework that has been used for both developing the tasks used to measure literacy and for understanding the meaning of what has been reported with respect to the comparative literacy proficiencies of adults in participating countries. The framework consists of six parts that represent a logical sequence of steps, from needing to define and represent a particular domain of interest, to identifying and operationalizing characteristics used to construct items, to providing an empirical basis for interpreting results. The various parts of the framework are seen as important in that they help to provide a deeper understanding of the construct of literacy and the various processes associated with it. A processing model is proposed and variables associated with performance on the literacy tasks are identified and verified through regression analyses. These variables are shown to account for between 79% and 89% of the variance in task difficulty. Collectively, these process variables provide a means for moving away from interpreting performance on large‐scale surveys in terms of discrete tasks or a single number, toward identifying levels of performance that have generalizability across pools of tasks and toward what Messick (1989) has called a higher level of measurement.
The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34. (1990)

The specific (6;9)(p23;q34) chromosomal translocation is associated with a defined subtype of acute nonlymphocytic leukemia (ANLL). The 9q34 breakpoint is located at the telomeric side of the c-abl gene. Through a combination of chromosome jumping, long-range mapping, and chromosome walking, the chromosome 9 breakpoints of several t(6;9) ANLL patients were localized within a defined region of 8 kilobases (kb), 360 kb telomeric of c-abl. Subsequent cDNA cloning revealed that this region represented an intron in the middle of a gene, called Cain (can), encoding a 7.5-kb transcript. Disruption of the can gene by the translocation resulted in the expression of a new 5.5-kb can mRNA from the 6p- chromosome. Isolation of chromosome 6 sequences showed that breakpoints on 6p23 also clustered within a limited stretch of DNA. These data strongly suggest a direct involvement of the translocation in the leukemic process of t(6;9) ANLL.
Understanding the Demographics of Twitter Users (2021)

Every second, the thoughts and feelings of millions of people across the world are recorded in the form of 140-character tweets using Twitter. However, despite the enormous potential presented by this remarkable data source, we still do not have an understanding of the Twitter population itself: Who are the Twitter users? How representative of the overall population are they? In this paper, we take the first steps towards answering these questions by analyzing data on a set of Twitter users representing over 1% of the U.S. population. We develop techniques that allow us to compare the Twitter population to the U.S. population along three axes (geography, gender, and race/ethnicity), and find that the Twitter population is a highly non-uniform sample of the population.
Isolation and Characterization of Cellulose/Arabinoxylan Residual Mixtures from Corn Fiber Gum Processes (2001)

ABSTRACT White, fluffy cellulose/arabinoxylan mixtures (CAX) were generated from the solid residues remaining after corn fiber gum (CFG) production. Most CAX were produced using variations of a process in which a single alkaline hydrogen peroxide (AHP) step was used for delignification and for CFG (arabinoxylan) extraction. The optimal ratio of H 2 O 2 to corn fiber to water was 0.1:1:20. Holding this ratio constant, time and temperature conditions were systematically varied, and yields of CAX and CFG determined. Parallel processes were conducted without H 2 O 2 to determine its effect on CAX and CFG yield. CAX prepared under identical conditions but without H 2 O 2 retained nearly twice the levels of CFG sugars, as revealed from L‐arabinose, D‐xylose, and D,L‐galactose levels. Even the CAX prepared under extreme AHP conditions (1 hr, 100°C), however, contained 32.9% of these CFG sugars. This CAX was obtained in a 25.1% yield, whereas those produced under less vigorous conditions were obtained in higher yields, because they retained more CFG. CAX prepared in the presence of H 2 O 2 hydrated very effectively, as indicated by their high swollen volumes and water absorbance values. This suggests potential food applications for CAX as a bulking agent. In addition, the open structure of the CAX matrix would render these residues suitable for chemical derivatization and enzymatic saccharification.
An advanced contrast enhancement using partially overlapped sub-block histogram equalization (2001)

An advanced histogram-equalization algorithm for contrast enhancement is presented. Histogram equalization is the most popular algorithm for contrast enhancement due to its effectiveness and simplicity. It can be classified into two branches according to the transformation function used: global or local. Global histogram equalization is simple and fast, but its contrast-enhancement power is relatively low. Local histogram equalization, on the other hand, can enhance overall contrast more effectively, but the complexity of computation required is very high due to its fully overlapped sub-blocks. In this paper, a low-pass filter-type mask is used to get a nonoverlapped sub-block histogram-equalization function to produce the high contrast associated with local histogram equalization but with the simplicity of global histogram equalization. This mask also eliminates the blocking effect of nonoverlapped sub-block histogram-equalization. The low-pass filter-type mask is realized by partially overlapped sub-block histogram-equalization (POSHE). With the proposed method, since the sub-blocks are much less overlapped, the computation overhead is reduced by a factor of about 100 compared to that of local histogram equalization while still achieving high contrast. The proposed algorithm can be used for commercial purposes where high efficiency is required, such as camcorders, closed-circuit cameras, etc.