gebhart/patrepeval huggingface dataset:
EVD-Based Detection for Multi-Cell Massive MIMO Network (2015)

This paper focuses on detection for multi-cell Massive MIMO network. As the column vectors are independent and identically distributed with each other, channel fast fading coefficient matrix is the eigenvector matrix for the covariance of received signal when the number of antennas at base stations (BSs) tends to infinity. Thus, we can get a set of normalized base vectors by eigenvalue decomposition of the covariance matrix for received signal. Based on this close relationship, an EVD (Eigenvalue Decomposition) based detection algorithm, which could solve the pilot contamination problem completely when the number of antennas at BS tends to infinity, is proposed. Simulation results show that the bit error rate (BER) could be reduced by two orders of magnitude when signal-to-noise ratio (SNR) is 40dB, with EVD-based detection algorithm, comparing with the traditional maximum-ratio combining (MRC) detection.
Prevention of Immune Reactions Triggered by First-Generation Adenoviral Vectors by Monoclonal Antibodies and CTLA4Ig (1996)

The therapeutic potential of adenovirus-mediated gene transfer using first-generation vectors is severely limited by the fact that only transient expression is achievable in immunocompetent animals. The loss in transgene expression can be attributed at least in part to the appearance of detrimental immune responses directed toward vector and/or transgene-encoded determinants. FK506 and cyclosporin A both reduced these immune responses. These immunosuppressants, however, may induce many severe side effects during prolonged use. An alternative strategy has been developed to overcome these problems following in vivo transfection of muscles of adult immunocompetent mice with a delta E1/E3a adenoviral vector encoding a beta-galactosidase (beta-Gal) expression cassette. YTS 177 (an anti-CD4 monoclonal antibody) as well as CTLA4Ig, a recombinant protein, partially controlled the immune responses. They were indeed able to reduce the muscle infiltration by CD4+ and CD8+ cells but they failed to repress the humoral response. Co-administration of YTS 191 (an anti-CD4), YTS 169 (an anti-CD8), and TIB 213 (an anti-CD11a) was, however, very efficient in blocking both cellular and humoral immune reactions. This combination of monoclonal antibodies allowed strong and stable transgene expression over 1 month. These data underline the potential of monoclonal antibodies as immunosuppressive adjunct treatment for adenovirus-mediated gene transfer.
Photodegradable, Photoadaptable Hydrogels via Radical-Mediated Disulfide Fragmentation Reaction (2011)

Various techniques have been adopted to impart a biological responsiveness to synthetic hydrogels for the delivery of therapeutic agents as well as the study and manipulation of biological processes and tissue development. Such techniques and materials include polyelectrolyte gels that swell and deswell with changes in pH, thermosensitive gels that contract at physiological temperatures, and peptide cross-linked hydrogels that degrade upon peptidolysis by cell-secreted enzymes. Herein we report a unique approach to photochemically deform and degrade disulfide cross-linked hydrogels, mitigating the challenges of light attenuation and low quantum yield, permitting the degradation of hydrogels up to 2 mm thick within 120 s at low light intensities (10 mW/cm(2) at 365 nm). Hydrogels were formed by the oxidation of thiol-functionalized 4-armed poly(ethylene glycol) macromolecules. These disulfide cross-linked hydrogels were then swollen in a lithium acylphosphinate photoinitiator solution. Upon exposure to light, photogenerated radicals initiate multiple fragmentation and disulfide exchange reactions, permitting and promoting photodeformation, photowelding, and photodegradation. This novel, but simple, approach to generate photoadaptable hydrogels portends the study of cellular response to mechanically and topographically dynamic substrates as well as novel encapsulations by the welding of solid substrates. The principles and techniques described herein hold implications for more than hydrogel materials but also for photoadaptable polymers more generally.
Motor Neuron Syndrome as a New Phenotypic Manifestation of Mutation 9185T>C in Gene MTATP6 (2014)

Background. The mutation 9185T>C in ATP6 gene, associated with Leigh syndrome, was reported in only few families. Motor neuron disease (MND), both clinically and electrophysiologically, was not previously described in association with this mutation. Case Report. 33-year-old male, with family history of mitochondrial disease, presented with cognitive impairment, exercise intolerance, and progressive muscle weakness. Examination revealed global hypotonia, and proximal tetraparesis, without atrophy or fasciculation, pyramidal signs, or sensory symptoms. The laboratory findings revealed an increase of lactate and lactate/pyruvate ratio; electromyogram showed chronic neurogenic compromise; muscle biopsy was suggestive of spinal muscular atrophy and mitochondriopathy; genetic study of SMN1 was negative but detected a homoplasmic mutation 9185T>C in ATP6 gene. His younger sister, with the same mutation, had cognitive impairment, ataxia, and muscle weakness. EMG showed axonal peripheral neuropathy. Conclusion. This case is unique because of the benignity and the coexistence of clinical, neurophysiological, and pathological findings suggestive of MND that, although described in mitochondrial disease, have not yet been reported in association with 9185T>C mutation. The present case contributes to the expansion of the phenotypic expressions of this particular mutation.
Fault Ride-Through Capability of Voltage-Controlled Inverters (2018)

An auxiliary voltage controller is proposed for the fault ride-through (FRT) control of voltage-controlled inverters used in distributed energy resources. The proposed auxiliary controller can be added to different existing voltage control strategies with minimum or no need to alter the original structure of the voltage controller. The proposed controller prevents the transient overcurrent during grid faults and controls the exchange of real and reactive powers according to the governing grid standard. A fault detection algorithm is also implemented to detect the fault instant and determine the interval of fault during which the real and reactive power references are adjusted accordingly. Complete stability analysis of the proposed controller is performed through a new model. Successful performance of the proposed controller in achieving FRT requirements of German and Danish codes are illustrated by simulations. Extensive real-time and experimental results are also presented and discussed.
Computational rim illumination with aerial robots (2014)

Lighting plays a major role in photography. Professional photographers use elaborate installations to light their subjects and achieve sophisticated styles. However, lighting moving subjects performing dynamic tasks presents significant challenges and requires expensive manual intervention. A skilled additional assistant might be needed to reposition lights as the subject changes pose or moves, and the extra logistics significantly raises costs and time.
Type 1 diabetes mellitus and risk of cancer: a meta-analysis of observational studies (2018)

This meta-analysis suggests that type 1 diabetes is associated with the increased risk of several types of cancer and the decreased risk of breast cancer. However, the plausible mechanisms for the decreased risk of breast cancer remain unclear. Further prospective studies with proper adjustment for possible confounding factors are warranted.
ADAPTIVE MUTATION: The Uses of Adversity (1993)

When populations of microorganisms are subjected to certain nonlethal selections, useful mutants arise among the nongrowing cells whereas useless mutants do not. This phenomenon, known as adaptive, directed, or selection-induced mutation, challenges the long-held belief that mutations only arise at random and without regard for utility. In recent years a growing number of studies have examined adaptive mutation in both bacteria and yeast. Although conflicts and controversies remain, the weight of the evidence indicates that adaptive mutation cannot be explained by trivial artifacts and that nondividing cells accumulate mutations in the absence of genomic replication. Because this process tends to produce only useful mutations, the cells appear to have a mechanism for preventing useless genetic changes from occurring or for eliminating them after they occur. The model that most readily explains the evidence is that cells under stress produce genetic variants continuously and at random, but these variants are immortalized as mutations only if they allow the cell to grow.
Evaluation of liposomal dose in recombinant factor VIII reconstituted with pegylated liposomes for the treatment of patients with severe haemophilia A (2008)

Patients with haemophilia A treated prophylactically require frequent factor VIII (FVIII) infusions for bleed protection. Recombinant sucrose-formulated FVIII (rFVIII-FS) with pegylated liposomes (PEGLip-rFVIII-FS) was previously shown to extend the bleed-free period after prophylactic infusion versus rFVIII-FS using two doses of FVIII with a fixed amount of liposomal diluent. This randomised, subject-blinded, four-way crossover study evaluated the efficacy and safety of PEGLip-rFVIII-FS using various quantities of pegylated liposomes with a fixed FVIII dose. Adults with severe haemophilia A were randomised to one of four treatment arms. Each arm had four treatment segments, with each segment consisting of a prophylactic infusion followed by on-demand infusions. The prophylactic infusions used a fixed dose of 35 IU/kg rFVIII-FS, but varied in the amount of pegylated liposomes used for reconstitution (4.2, 12.6, or 22.1 mg/kg of body weight or water as a control). On-demand infusions all used 35 IU/kg rFVIII-FS. After treatment of spontaneous bleeds and a wash-out, subjects crossed to another treatment segment (i.e. another PEGLip-rFVIII-FS dose or control). Sixteen subjects enrolled in and completed the study. Mean number of bleed-free days after prophylactic infusion increased from 7.8 days for control rFVIII-FS to 8.7, 10.8, and 10.9 days for PEGLip-rFVIII-FS reconstituted in 4.2, 12.6, and 22.1 mg/kg of pegylated liposomes, respectively. The difference in bleed-free days approached but did not achieve statistical significance in this small study population. No drug-related adverse events or inhibitors were reported. This study helps establish the optimal concentration of liposomes in PEGLip-rFVIII-FS to prolong the post-infusion bleed-free period.
Adversarial Machine Learning And Speech Emotion Recognition: Utilizing Generative Adversarial Networks For Robustness (2018)

Deep learning has undoubtedly offered tremendous improvements in the performance of state-of-the-art speech emotion recognition (SER) systems. However, recent research on adversarial examples poses enormous challenges on the robustness of SER systems by showing the susceptibility of deep neural networks to adversarial examples as they rely only on small and imperceptible perturbations. In this study, we evaluate how adversarial examples can be used to attack SER systems and propose the first black-box adversarial attack on SER systems. We also explore potential defenses including adversarial training and generative adversarial network (GAN) to enhance robustness. Experimental evaluations suggest various interesting aspects of the effective utilization of adversarial examples useful for achieving robustness for SER systems opening up opportunities for researchers to further innovate in this space.
Ru-Catalyzed Asymmetric Hydrogenation of α-Ketoesters with CeCl<sub>3</sub>·7H<sub>2</sub>O as Additive (2005)

An efficient asymmetric hydrogenation of α-ketoesters is reported with use of a catalyst prepared from [Ru((S)-3)(benzene)Cl]Cl and CeCl3·7H2O. α-Hydroxy esters are obtained in up to 96% ee. The addition of CeCl3·7H2O not only improves the enantioselectivity, but also enhances the stability of the catalyst. As a result, the hydrogenation of methyl benzoylformate affords the product with 92% ee with a substrate/catalyst ratio of 10 000. Hydrolysis of 2 provides the final compound with 83% yield at 99% ee after a single recrystallization from 1,2-dichloroethylene.
A new patterning process concept for large-area transistor circuit fabrication without using an optical mask aligner (1994)

A new concept to produce large thin film transistor liquid crystal displays (TFT-LCD's) without using an optical mask aligner is proposed which emphasizes patterning technology. Some experimental thin film transistors (TFT's) are fabricated according to the concept and operated like conventional transistors fabricated by using an optical mask aligner. The concept includes improvement of printing technology and development of a double-layer resist method. The latter method employs a printed ink pattern and a photoresist. This prevents contamination of thin films by metal impurities which affect electrical characteristics of the TFT's. A special gravure offset printing technology is proposed, composed of a large thixotropy valued UV ink, and a fine, precision etched glass intaglio. The experimental TFT's, with a designed minimum gate length of 10 /spl mu/m, have comparable electric characteristics to those of conventional poly-Si TFT's.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Novel method for determination of flow velocities with pulsed nuclear magnetic resonance (1978)

A method for the determination of flow velocities with pulsed nuclear magnetic resonance is presented, based on a sequence of inhomogeneous 180 degrees pulses and a gradient in the stationary magnetic field. Results are shown for a capillary containing water with flow velocities in the range of 0.5 to 5 mm/s.
Pain and the Neuromatrix in the Brain (2001)

The neuromatrix theory of pain proposes that pain is a multidimensional experience produced by characteristic "neurosignature" patterns of nerve impulses generated by a widely distributed neural network-the "body-self neuromatrix"-in the brain. These neurosignature patterns may be triggered by sensory inputs, but they may also be generated independently of them. Acute pains evoked by brief noxious inputs have been meticulously investigated by neuroscientists, and their sensory transmission mechanisms are generally well understood. In contrast, chronic pain syndromes, which are often characterized by severe pain associated with little or no discernible injury or pathology, remain a mystery. Furthermore, chronic psychological or physical stress is often associated with chronic pain, but the relationship is poorly understood. The neuromatrix theory of pain provides a new conceptual framework to examine these problems. It proposes that the output patterns of the body-self neuromatrix activate perceptual, homeostatic, and behavioral programs after injury, pathology, or chronic stress. Pain, then, is produced by the output of a widely distributed neural network in the brain rather than directly by sensory input evoked by injury, inflammation, or other pathology. The neuromatrix, which is genetically determined and modified by sensory experience, is the primary mechanism that generates the neural pattern that produces pain. Its output pattern is determined by multiple influences, of which the somatic sensory input is only a part, that converge on the neuromatrix.
From models to pathogens: how much have we learned about <i> <scp>S</scp> treptococcus pneumoniae </i> cell division? (2013)

Streptococcus pneumoniae is an oval-shaped Gram-positive coccus that lives in intimate association with its human host, both as a commensal and pathogen. The seriousness of pneumococcal infections and the spread of multi-drug resistant strains call for new lines of intervention. Bacterial cell division is an attractive target to develop antimicrobial drugs. This review discusses the recent advances in understanding S. pneumoniae growth and division, in comparison with the best studied rod-shaped models, Escherichia coli and Bacillus subtilis. To maintain their shape, these bacteria propagate by peripheral and septal peptidoglycan synthesis, involving proteins that assemble into distinct complexes called the elongasome and the divisome, respectively. Many of these proteins are conserved in S. pneumoniae, supporting the notion that the ovococcal shape is also achieved by rounds of elongation and division. Importantly, S. pneumoniae and close relatives with similar morphology differ in several aspects from the model rods. Overall, the data support a model in which a single large machinery, containing both the peripheral and septal peptidoglycan synthesis complexes, assembles at midcell and governs growth and division. The mechanisms generating the ovococcal or coccal shape in lactic-acid bacteria have likely evolved by gene reduction from a rod-shaped ancestor of the same group.
Dinner with my Brother (2004)

Went to my brother's new town house for dinner last night. Bro cooked up a fine dinner - sweet and sour pork using the traditional recipe passed down from generation to generation within our family. After dinner, we got into a discussion re our Chinese names and their meanings. We both agreed that the meaning of a person's name seems to be more significant in Chinese culture than in Australian culture.
Design of Progressive Cavity Pump Wells (2008)

Abstract Progressive cavity pumps (PCPs) are a special type of rotary positive displacement pumps. PCP was first introduced in petroleum engineering as an artificial lift method in 1970's, and is becoming a popular lift tool for its advantages of broader applications, less maintenance, and higher efficiency. PCP performances have been studied for many years, but no published paper has discussed the relation of pump performances with well performances systematically. This paper analyzes the system performances of PCP wells. Using nodal analysis method, the paper presents algorithms and procedures to design pump rotational speed and production rate from well inflow and outflow performances. For the effect of viscosity on pump volumetric slip, unlike traditional methods of trying to set up a general correlation for all PCP types, the paper propose a method to correct the effect of viscosity on each pump's catalog performance curves, and demonstrates how to use the corrected performances to design the pumping of viscous fluid. By unfolding a PCP cavity and using simplified slot flow, this paper presents correlations to determine the critical pump intake pressures for filling pump cavity completely for Newtonian and non-Newtonian fluids. The presented algorithms can be used not only to design a PCP well for pump rotational speed and production rate, but also to analyze the performance of a PCP pumping well. The presented correlations of the viscosity effect on slippage and the critical pump intake pressure are useful in PCP design and system analysis.
Employing Intelligent Agents to Automate SLA Creation (2007)

Service Level Agreements (SLAs) are commonly prepared and signed agreements that form the contracts between a service provider and its customers, defining the obligations and liabilities of the parties. Naturally, SLAs should reflect the business needs of both customer and supplier. SLAs are usually formed through either the adoption of a boilerplate agreement from the provider, or through a mediation/negotiation process between the parties. With the increasing adoption of software supply being implemented as a network service, such schemes are rigid or slow and costly, This paper proposes a system that the parties can use to facilitate both fast and flexible agreements. It proposes automation of SLA creation from a set of Service Level Objectives (SLOs), making use of software agents and adopting a social order function by incorporating it into the decision process.
Measurement and analysis of defocused point spread functions and optical transfer functions of a microscope (2002)

The defocused point spread functions and optical transfer functions of a microscope were measured and analyzed. The main purpose of the analysis was to verify the accuracy of analytical approximations of these functions, which were presented but not extensively studied in the literature. The measured results were compared with those calculated by Castleman's (1979) theoretical approximation, in the space and frequency domains, graphically and numerically. The results showed that for the numerical apertures used, the theoretical functions were close to the measured functions, and thus Castleman's theoretical approximation is a fairly good approximation. These defocused point spread functions are being used for the optical sectioning as part of microscope image visualization system described by Li, Agathokils, Peet, Jensen and Sahota (see Proceedings of 1993 Canadian Conference on Electrical and Computer Engineering, p.1013-1016, Sept. 1993, Vancouver).
Alteration in restriction enzyme digestion patterns detects DNA-protein complexes induced by chromate (1991)

DNA--protein complexes isolated from CHO cells treated with at least 10-30 microM potassium chromate exhibited an alteration in the degradation of the DNA by restriction enzymes compared to DNA--protein complexes isolated from untreated cells. This alteration in restriction enzyme digestion of DNA--protein complexes induced by chromate was shown to depend upon the binding of trivalent chromium to the DNA and upon the protein associated with the DNA, since both EDTA pretreatment and protease K reversed the inhibition of restriction enzyme degradation of the DNA. The inhibition of restriction enzyme degradation of DNA--protein complexes may be utilized as an indirect way to detect DNA--protein complexing induced by chromate and perhaps other agents.
Frameworks = (components + patterns) (1997)

article Free Access Share on Frameworks = (components + patterns) Author: Ralph E. Johnson Univ. of Illinois-Urbana, Urbana Univ. of Illinois-Urbana, UrbanaView Profile Authors Info & Claims Communications of the ACMVolume 40Issue 10Oct. 1997 pp 39–42https://doi.org/10.1145/262793.262799Published:01 October 1997Publication History 283citation5,793DownloadsMetricsTotal Citations283Total Downloads5,793Last 12 Months435Last 6 weeks78 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF