gebhart/patrepeval huggingface dataset:
Vacuum polarization induced by a cylindrical boundary in the cosmic string spacetime (2006)

In this paper we investigate the Wightman function, the renormalized vacuum expectation values of the field square, and the energy-momentum tensor for a massive scalar field with general curvature coupling inside and outside of a cylindrical shell in the generalized spacetime of straight cosmic string. For the general case of Robin boundary condition, by using the generalized Abel-Plana formula, the vacuum expectation values are presented in the form of the sum of boundary-free and boundary-induced parts. The asymptotic behavior of the vacuum expectation values of the field square, energy density, and stresses are investigated in various limiting cases. The generalization of the results to the exterior region is given for a general cylindrically symmetric static model of the string core with finite support.
The IDA-LIKE peptides IDL6 and IDL7 are negative modulators of stress responses in Arabidopsis thaliana (2017)

Small signalling peptides have emerged as important cell to cell messengers in plant development and stress responses. However, only a few of the predicted peptides have been functionally characterized. Here, we present functional characterization of two members of the IDA-LIKE (IDL) peptide family in Arabidopsis thaliana, IDL6 and IDL7. Localization studies suggest that the peptides require a signal peptide and C-terminal processing to be correctly transported out of the cell. Both IDL6 and IDL7 appear to be unstable transcripts under post-transcriptional regulation. Treatment of plants with synthetic IDL6 and IDL7 peptides resulted in down-regulation of a broad range of stress-responsive genes, including early stress-responsive transcripts, dominated by a large group of ZINC FINGER PROTEIN (ZFP) genes, WRKY genes, and genes encoding calcium-dependent proteins. IDL7 expression was rapidly induced by hydrogen peroxide, and idl7 and idl6 idl7 double mutants displayed reduced cell death upon exposure to extracellular reactive oxygen species (ROS). Co-treatment of the bacterial elicitor flg22 with IDL7 peptide attenuated the rapid ROS burst induced by treatment with flg22 alone. Taken together, our results suggest that IDL7, and possibly IDL6, act as negative modulators of stress-induced ROS signalling in Arabidopsis.
The development and performance characteristics of mixed flowing gas test environment (1988)

Three flowing mixed gases have been developed to achieve realistic simulation through the synergistic effects of (1) low concentrations of relevant pollutants, (2) humidity, and (3) temperature. The authors have demonstrated the importance of incorporating the sulfide-chloride synergisms into reproduced indoor field environments in order to simulate the observed corrosion response. By adjusting these variables, large differences can be found in materials reaction rates, corrosion mechanisms, and chemistries. Data were taken that demonstrate the effects of critical variables on corrosion processes. Relative humidity, reactive chloride concentration, and reactive sulfide concentration were consistently identified as the most important in all cases. Temperature, gas velocity, and NO/sub 2/ concentration were found to be far less critical. Sulfur dioxide was relatively unimportant for either indoor, field, or laboratory mixtures. It is concluded that three-component mixtures based on low levels of H/sub 2/S, NO/sub 2/, and Cl/sub 2/ can be used to simulate all reactive environment classes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Probing surface microheterogeneity of poly(ether urethanes) in an aqueous environment (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProbing surface microheterogeneity of poly(ether urethanes) in an aqueous environmentK. G. Tingey and J. D. AndradeCite this: Langmuir 1991, 7, 11, 2471–2478Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://doi.org/10.1021/la00059a013RIGHTS & PERMISSIONSArticle Views261Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
73. Arylpyridines. Part I. Phenylpyridines and nitrophenylpyridines (1940)

The first page of this article is displayed as the abstract.
Whitening-rotation-based semi-blind MIMO channel estimation (2006)

This paper proposes a whitening-rotation (WR)-based algorithm for semi-blind estimation of a complex flat-fading multi-input multi-output (MIMO) channel matrix H. The proposed algorithm is based on decomposition of H as the matrix product H=WQ/sup H/, where W is a whitening matrix and Q is unitary rotation matrix. The whitening matrix W can be estimated blind using only received data while Q is estimated exclusively from pilot symbols. Employing the results for the complex-constrained Cramer-Rao Bound (CC-CRB), it is shown that the lower bound on the mean-square error (MSE) in the estimate of H is directly proportional to its number of unconstrained parameters. Utilizing the bounds, the semi-blind scheme is shown to be very efficient when the number of receive antennas is greater than or equal to the number of transmit antennas. Closed-form expressions for the CRB of the semi-blind technique are presented. Algorithms for channel estimation based on the decomposition are also developed and analyzed. In particular, the properties of the constrained maximum-likelihood (ML) estimator of Q for an orthogonal pilot sequence is examined, and the constrained estimator for a general pilot sequence is derived. In addition, a Gaussian likelihood function is considered for the joint optimization of W and Q, and its performance is studied. Simulation results are presented to support the algorithms and analysis, and they demonstrate improved performance compared to exclusively training-based estimation.
Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation (2009)

Bone tissue arises from mesenchymal cells induced into the osteoblast lineage by essential transcription factors and signaling cascades. MicroRNAs regulate biological processes by binding to mRNA 3'-untranslated region (UTR) sequences to attenuate protein synthesis. Here we performed microRNA profiling and identified miRs that are up-regulated through stages of osteoblast differentiation. Among these are the miR-29, miR-let-7, and miR-26 families that target many collagens and extracellular matrix proteins. We find that miR-29b supports osteoblast differentiation through several mechanisms. miR-29b decreased and anti-miR-29b increased activity of COL1A1, COL5A3, and COL4A2 3'-UTR sequences in reporter assays, as well as endogenous gene expression. These results support a mechanism for regulating collagen protein accumulation during the mineralization stage when miR-29b reaches peak levels. We propose that this mechanism prevents fibrosis and facilitates mineral deposition. Our studies further demonstrate that miR-29b promotes osteogenesis by directly down-regulating known inhibitors of osteoblast differentiation, HDAC4, TGFbeta3, ACVR2A, CTNNBIP1, and DUSP2 proteins through binding to target 3'-UTR sequences in their mRNAs. Thus, miR-29b is a key regulator of development of the osteoblast phenotype by targeting anti-osteogenic factors and modulating bone extracellular matrix proteins.
Results of the WMT16 Metrics Shared Task (2016)

This paper presents the results of the WMT16 Metrics Shared Task. We asked participants of this task to score the outputs of the MT systems involved in the WMT16 Shared Translation Task. We collected scores of 16 metrics from 9 research groups. In addition to that, we computed scores of 9 standard metrics (BLEU, SentBLEU, NIST, WER, PER, TER and CDER) as baselines. The collected scores were evaluated in terms of system-level correlation (how well each metric's scores correlate with WMT16 official manual ranking of systems) and in terms of segment level correlation (how often a metric agrees with humans in comparing two translations of a particular sentence).
Preparation, Characterization, DNA Binding, and <i>in Vitro</i> Cytotoxicity of the Enantiomers of the Platinum(II) Complexes <i>N</i>-Methyl-, <i>N</i>-Ethyl- and <i>N</i>,<i>N</i>-Dimethyl-(<i>R</i>)- and -(<i>S</i>)-3-aminohexahydroazepinedichloroplatinum(II) (1997)

A series of chiral diaminedichloroplatinum(II) complexes derived from [Pt(ahaz)Cl2] (ahaz = 3-aminohexahydroazepine) have been synthesized and tested for cytotoxic activity. Novel synthetic pathways were developed to produce the structural derivatives of the ahaz ligand, with alkyl substituents on the exocyclic nitrogen atom. The platinum(II) complexes of these ligands were synthesized and characterized by NMR and CD spectroscopy, confirming isomeric and enantiomeric purity. The crystal structures of three of these complexes, [Pt(S-meahaz)-Cl2], [Pt(R-etahaz)Cl2], and [Pt(S-dimeahaz)Cl2] (meahaz = N-methylahaz, etahaz = N-ethylahaz, dimeahaz = N,N-dimethylahaz), have been determined to establish the orientation of the protons and alkyl substituents on the nitrogen donor atoms. In vitro assays of the cytotoxic activity of the complexes have revealed a significant and reproducible enantioselective trend with the R-enantiomers more active than the S-enantiomers in all cell lines. Increasing the steric bulk on the amine groups was found to have only a modest effect on activity. No enantioselectivity was observed in the binding of R- and S-[Pt(etahaz)Cl2] to calf-thymus DNA.
The growth hormone/insulin-like growth factor axis and breast cancer risk (1993)

Raised circulating levels of both insulin and insulin-like growth factor 1 (IGF-1) have recently been shown to be risk markers for breast cancer in pre- and postmenopausal women. If these raised levels are shown to be present prior to the clinical manifestation of breast cancer then the abnormalities may help to identify endocrine/metabolic factors which favour promotion of mammary carcinogenesis. Western diets may cause early onset of insulin resistance and the resulting hyperinsulinaemia can lead to endocrine/metabolic dysfunction. Exposure of mammary tissue to an abnormal sex hormone steroid profile associated with increased tissue activity of IGF-1, may increase epithelial proliferation and increase the risk of developing precancerous lesions. The newly recognised risk markers for breast cancer may be linked to other clinical risk markers such as early onset of menarche, relative tallness and upper-body type obesity in women.
Stochastic imprinting in the progeny of Dnmt3L−/− females (2006)

The cis-acting regulatory sequences of imprinted genes are subject to germline-specific epigenetic modifications, the imprints, so that this class of genes is exclusively expressed from either the paternal or maternal allele in offspring. How genes are differentially marked in the germlines remains largely to be elucidated. Although the exact nature of the mark is not fully known, DNA methylation [at differentially methylated regions (DMRs)] appears to be a major, functional component. Recent data in mice indicate that Dnmt3a, an enzyme with de novo DNA methyltransferase activity, and the related protein Dnmt3L are required for methylation of imprinted loci in germ cells. Maternal methylation imprints, in particular, are strictly dependent on the presence of Dnmt3L. Here, we show that, unexpectedly, methylation imprints can be present in some progeny of Dnmt3L(-/-) females. This incomplete penetrance of the effect of Dnmt3L deficiency in oocytes is neither embryo nor locus specific, but stochastic. We establish that, when it occurs, methylation is present in both embryo and extra-embryonic tissues and results in a functional imprint. This suggests that this maternal methylation is inherited, directly or indirectly, from the gamete. Our results indicate that in the absence of Dnmt3L, factors such as Dnmt3a and possibly others can act alone to mark individual DMRs. However, establishment of appropriate maternal imprints at all loci does require a combination of all factors. This observation can provide a basis to understand mechanisms involved in some sporadic cases of imprinting-related diseases and polymorphic imprinting in human.
A compact model for multiterminal bipolar devices used in smart power applications (1998)

Complex technologies merging low-voltage bipolar devices and vertical current-flow power transistor allow more smart functions at low chip cost but pose problems during the design phase because there is no way to predict the influence of the high-voltage transistor over the control components by using standard bipolar junction transistor (BJT) models. In fact the large inductive load usually present in high-voltage power transistors applications forces both negative substrate voltage and spurious currents that can induce positive feedback among parasitic devices, downgrading the performance of a single device and so of the whole circuit. In this work we introduce a model for the five-terminal bipolar devices used in smart power applications. The model accounts for all main static and dynamic parasitic effects and gives results in very good agreement with experimental data on both simple devices and complex integrated circuits currently implemented in commercial products for microprocessor based engine management systems (EMS's).
Comparing density forecast models (2007)

Abstract In this paper we discuss how to compare various (possibly misspecified) density forecast models using the Kullback–Leibler information criterion (KLIC) of a candidate density forecast model with respect to the true density. The KLIC differential between a pair of competing models is the (predictive) log‐likelihood ratio (LR) between the two models. Even though the true density is unknown, using the LR statistic amounts to comparing models with the KLIC as a loss function and thus enables us to assess which density forecast model can approximate the true density more closely. We also discuss how this KLIC is related to the KLIC based on the probability integral transform (PIT) in the framework of Diebold et al. (1998). While they are asymptotically equivalent, the PIT‐based KLIC is best suited for evaluating the adequacy of each density forecast model and the original KLIC is best suited for comparing competing models. In an empirical study with the S&P500 and NASDAQ daily return series, we find strong evidence for rejecting the normal‐GARCH benchmark model, in favor of the models that can capture skewness in the conditional distribution and asymmetry and long memory in the conditional variance. Copyright © 2007 John Wiley & Sons, Ltd.
Effects of epidermal growth factor (EGF), platelet‐derived growth factor (PDGF) and fibroblast growth factor (FGF) on human adipocyte development and function (1995)

We investigated the effects of epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) on the differentiation of human adipocyte precursor cells and some metabolic aspects of newly formed fat cells kept in primary culture. Exposure of stromal cells from human adipose tissue to EGF (0.01-100 ng mL-1) resulted in a dose- and time-dependent decrease in the number of developing fat cells and the activity of glycerol-3-phosphate dehydrogenase (GPDH), a marker of adipose differentiation. Continuous presence of EGF completely blocked lipid accumulation with a ED50 in the range of 0.2 ng mL-1. This inhibitory action of EGF was associated with a potent stimulation of cell proliferation, up to 8-fold compared with cultures in the absence of EGF. PDGF (0.1-50 ng mL-1) and FGF (0.1-100 ng mL-1) provoked a less marked suppression of GPDH activities which was significant at concentrations of 10 ng mL-1 and higher. A 12 day exposure to EGF of differentiated cells was followed by a suppression of GPDH and, again, a significant increase in cell number. Concomitantly, a distinct loss of cellular lipids was observed in the newly formed adipocytes. This effect could be partly explained by a stimulation of lipolysis, since EGF caused an increase of glycerol in the culture medium. Addition of PDGF or FGF to newly developed fat cells had no effect on lipolysis but, at higher concentrations, also decreased GPDH activity.(ABSTRACT TRUNCATED AT 250 WORDS)
Performance analysis of the 802.11ax UL OFDMA random access protocol in dense networks (2017)

Recently, 802.11ax has introduced uplink Orthogonal Frequency Division Multiple Access (UL OFDMA)-based random access transmission to provide uplink multiuser capability to stations (STA) with unknown buffer status. These STAs include those that are waking up from sleep and unassociated STAs trying to establish connection for the first time. Due to the absence of carrier sensing per resource unit, this procedure has a maximum efficiency of only about 37% for high number of STAs. The efficiency will decrease further without properly choosing the random access parameters. In this paper, we first build an analytical model of the performance of UL OFDMA random access transmission and verify it using simulations. In addition, we propose methods to optimize various random access parameters to maintain a system efficiency near the 37% limit. Simulation results show that our optimization methods can increase the throughput of UL OFDMA random access by as much as 39% when compared to randomly chosen parameters.
Silicon Heterojunction Solar Cells on n- and p-Type Wafers with Efficiencies above 20% (2012)

A systematic comparison of front- and rear-emitter silicon heterojunction solar cells produced on nand p-type wafers was performed, in order to investigate their potential and limitations for high efficiencies. Cells on p-type wafers suffer from reduced minority carrier lifetime in the low-carrier-injection range, mainly due to the asymmetry in interface defect capture cross sections. This leads to slightly lower fill factors than for n-type cells. However, these losses can be minimized by using high-quality passivation layers. High Vocs were obtained on both types of FZ wafers: up to 735 mV on n- and 726 mV on p-type. The best Voc measured on CZ p-type wafers was only 692 mV, whereas it reached 732 mV on CZ n-type. The highest aperture-area certified efficiencies obtained on 4 cm2 cells were 22.14% (Voc=727 mV, FF=78.4%) and 21.38% (Voc=722 mV, FF=77.1%) on n- and p-type FZ wafers, respectively, demonstrating that heterojunction schemes can perform almost as well on high-quality p-type as on ntype wafers. To our knowledge, this is the highest efficiency for a full silicon heterojunction solar cell on a p-type wafer, and the highest Voc on any p-type crystalline silicon device with reasonable FF.
Anticancer activities of fatty acids and their heterocyclic derivatives (2020)

Traditional chemotherapy relies on the premise that rapidly proliferating cancer cells are more likely to be killed by a cytotoxic agent, but in reality, the long-standing problem of chemotherapy is the lack of tumor-specific treatments. Apart from the impact on tumor cells, the drugs' major limitation is their severe adverse side effects on normal cells and tissues. Nutritional and epidemiological studies have indicated that cancer progression is correlated with the consumption of fatty acids, but the exact mechanisms still remain unknown. In the first part of our review, we discussed the beneficial effects of free fatty acids (saturated and unsaturated) on the progress of carcinogenesis in different tumor cell lines. We presented various mechanisms proposed in the literature, which explain the possible impact on the cells metabolism. The second part describes modifications of different fatty acids with existing anticancer drugs and heterocyclic moieties by condensation reactions. Such conjugations increased the tissue selectivity and made chemotherapy potentially more effective and less toxic in in vivo and in vitro studies. This fatty acid modifications, which change the activity of compounds, their uptake selectivity and alter drug delivery methods, may be the key to unlocking true medical potential of fatty acids.
<sup>124</sup>Iodine: A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging (2014)

(124)Iodine ((124)I) with its 4.2 d half-life is particularly attractive for in vivo detection and quantification of longer-term biological and physiological processes; the long half-life of (124)I is especially suited for prolonged time in vivo studies of high molecular weight compounds uptake. Numerous small molecules and larger compounds like proteins and antibodies have been successfully labeled with (124)I. Advances in radionuclide production allow the effective availability of sufficient quantities of (124)I on small biomedical cyclotrons for molecular imaging purposes. Radioiodination chemistry with (124)I relies on well-established radioiodine labeling methods, which consists mainly in nucleophilic and electrophilic substitution reactions. The physical characteristics of (124)I permit taking advantages of the higher PET image quality. The availability of new molecules that may be targeted with (124)I represents one of the more interesting reasons for the attention in nuclear medicine. We aim to discuss all iodine radioisotopes application focusing on (124)I, which seems to be the most promising for its half-life, radiation emissions, and stability, allowing several applications in oncological and nononcological fields.