gebhart/patrepeval huggingface dataset:
Numerical Linear Algebra for High-Performance Computers (1998)

From the Publisher:
This book presents a unified treatment of recently developed techniques and current understanding about solving systems of linear equations and large scale eigenvalue problems on high-performance computers. It provides a rapid introduction to the world of vector and parallel processing for these linear algebra applications. 
Topics include major elements of advanced-architecture computers and their performance, recent algorithmic development, and software for direct solution of dense matrix problems, direct solution of sparse systems of equations, iterative solution of sparse systems of equations, and solution of large sparse eigenvalue problems. 
This book supersedes the SIAM publication Solving Linear Systems on Vector and Shared Memory Computers, which appeared in 1990. The new book includes a considerable amount of new material in addition to incorporating a substantial revision of existing text. 
About the Authors: 
Jack J. Dongarra is a Distinguished Professor of Computer Science at the University of Tennessee and a Distinguished Scientist at Oak Ridge National Laboratory. Iain S. Duff is Group Leader of Numerical Analysis at the CCLRC Rutherford Appleton Laboratory, the Project Leader for the Parallel Algorithms Group at CERFACS in Toulouse, and a Visiting Professor of Mathematics at the University of Strathclyde. Danny C. Sorensen is a Professor of Computational and Applied Mathematics at Rice University. Henk A. van der Vorst is a Professor in Numerical Analysis at Utrecht University in the Netherlands.
Novel Pyrazolo[3,4-<i>d</i>]pyrimidine-Based Inhibitors of <i>Staphlococcus aureus</i> DNA Polymerase III:  Design, Synthesis, and Biological Evaluation (2003)

6-Anilinopyrazolo[3,4-d]pyrimidin-4-ones are novel dGTP analogues that inhibit the replication-specific enzyme DNA polymerase III (DNA pol III) of Staphlococcus aureus and other Gram-positive (Gr+) bacteria. To enhance the potential of these inhibitors as antimicrobial agents, a structure-activity relationship was developed involving substitutions at the 2, 4, and pyrazolo NH positions. All of the new inhibitors were tested for their ability to inhibit S. aureus DNA pol III and the growth of several other Gr+ bacteria in culture. 2-Anilino groups with small hydrophobic groups in the meta or para position enhanced both antipolymerase and antimicrobial activity. 2-Benzyl-substituted inhibitors were substantially less active. Substitution in the 4-position by oxygen gave the optimal activity, whereas substitution at the pyrazolo NH was not tolerated. These pyrazolo[3,4-d]pyrimidine derivatives represent a novel class of antimicrobials with promising activities against Gr+ bacteria.
Protein sequence analysis of a novel 103‐kDa <i>Dermatophagoides pteronyssinus</i> mite allergen and prevalence of serum immunoglobulin E reactivity to rDer p 11 in allergic adult patients (2004)

The 103-kDa Der p 11 appears to be major Dp mite allergen with a high frequency of IgE reactivity in sera of patients allergic to mites.
Syntheses of Basic Phenyl Alkyl Ethers. XII (1958)

Four kinds of the known N, N-diethyl-2-(6-allyl-2-R-phenoxy) ethylamines [R: methoxy (A), methoxycarbonyl (B), propionyl (C), and phenyliminomethyl (D)] show excellent uterus contracting action, while N-2-chloroethyl-N-ethyl-2-(2-benzylphenoxy) ethylamine (E) and N, N-diethyl-2-(2-benzyl-6-chlorophenoxy) ethylamine (F) possess strong antiadrenaline action. Various kinds of N, N-dialkyl-2-(o-allylaryloxy) ethylamines (XV to XXXII) were synthesized in order to examine the variation in physiological activity on the introduction of allyl, chlorine, nitro, or amino radical, relation between allyl and chlorine, and increase of molecular weight and changes is aromaticity, based on the foregoing facts.
Robust textual inference via learning and abductive reasoning (2005)

We present a system for textual inference (the task of inferring whether a sentence follows from another text) that uses learning and a logical-formula semantic representation of the text. More precisely, our system begins by parsing and then transforming sentences into a logical formula-like representation similar to the one used by (Harabagiu et al., 2000). An abductive theorem prover then tries to find the minimum “cost ” set of assumptions necessary to show that one statement follows from the other. These costs reflect how likely different assumptions are, and are learned automatically using information from syntactic/semantic features and from linguistic resources such as WordNet. If one sentence follows from the other given only highly plausible, low cost assumptions, then we conclude that it can be inferred. Our approach can be viewed as combining statistical machine learning and classical logical reasoning, in the hope of marrying the robustness and scalability of learning with the preciseness and elegance of logical theorem proving. We give experimental results from the recent PASCAL RTE 2005 challenge competition on recognizing textual inferences, where a system using this inference algorithm achieved the highest confidence weighted score.
Puzzling associations between childhood infections and the later occurrence of asthma and atopy (2000)

The current unfavourable trends in asthma and atopy prevalences have raised great concern and have challenged investigators to accelerate search for new risk factors for atopic diseases. The lack or scarcity of intense, systemic infections in early life has been postulated to increase susceptibility of becoming sensitized to otherwise harmless allergens in later life. This hygiene hypothesis is considered one of the most plausible explanations for the current trends in atopic diseases to date. There are data to suggest that measles, hepatitis A, and Mycobacterium tuberculosis infection in early life may prevent the subsequent development of atopic diseases. The hypothesis is based on the concept that certain viral and bacterial infections, which induce a strongly polarized T helper (Th)-1 type response and a long-lasting memory immunity, are in early life able to reverse or prevent the biased Th1/Th2 balance in individuals prone to atopy and asthma. Evidence for the ability of mycobacterial infections to alter the Th1/Th2 balance has also been obtained from murine models. In humans, the critical time period during which immunomodulation with long-lasting effects is considered most successful is within the first two years of life. Possibly also nonpathogenic residents of the intestinal mucosa are involved in the proper maturation of the immune system. The use of antibiotics has been shown to be positively associated with the development of asthma and atopy. The mechanisms underlying these associations remain largely unknown.
Brush Country Woman (1989)

Journal Article Brush Country Woman Get access Brush Country Woman. By Holland Ada Morehead. (College Station: Texas A ' M University Press, 1988. xix + 216 pp. Illustrations, map, bibliography. $17.50.) J'Nell L. Pate J'Nell L. Pate Tarrant County Junior College, Fort Worth Search for other works by this author on: Oxford Academic Google Scholar Western Historical Quarterly, Volume 20, Issue 2, May 1989, Pages 221–222, https://doi.org/10.2307/969351 Published: 01 May 1989
Enantioselective Synthesis of (−)‐Englerins A and B (2010)

All that glitters is gold: The total synthesis of the natural enantiomers of englerins A and B has been completed using a gold-catalyzed stereoselective domino alkyne/alkene/carbonyl cyclization of an enyne with an unprotected alcohol group at a stereogenic allylic position (see scheme; TES=triethylsilyl). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
[Reevaluation of the surgical indications for non-small cell lung cancer based on the results of postoperative treatment]. (2001)

Patients who undergo complete surgical resection for pathological stage I-IIIa non-small cell lung cancer (NSCLC) are candidates for postoperative chemo- and/or radiotherapy. The indications for surgical resection are not a problematic issue, regardless of the results of postoperative therapy. So far there have been no definitively positive results in randomized phase III trials comparing postoperative adjuvant therapy with no further therapy. Therefore clinical trials should be conducted to determine the most appropriate postoperative regimen in NSCLC.
Immunomodulation of AβPP Processing Alleviates Amyloid-β-Related Pathology in Alzheimer's Disease Transgenic Mice (2010)

Among the different paradigms aimed at interfering with amyloid-β (Aβ)-related pathology, the attenuation of amyloid-β protein precursor (AβPP) processing to limit Aβ levels seems to be a promising one. Along with the development of BACE1 inhibitors, and the generation of its knock-out mice, accumulating data raise concerns regarding a total inhibition of the enzyme as it shares the processing of other substrates. We described a novel approach to interfere with the specific interaction between AβPP and BACE1 using monoclonal antibodies directed to the β-secretase cleavage site upon the substrate, AβPP. Such antibodies limit AβPP cleavage in a cellular model of Alzheimer's disease (AD) and avoid the total inhibition of BACE1. Here, we demonstrate the ability of AβPP β-site antibodies to interfere with Aβ production in vivo. Systemic antibody treatment diminished Aβ plaques, membrane-associated oligomers, and intracellular Aβ accumulation, all of which have been implicated in cellular death and synaptic loss, suggesting that this approach may be an applicable strategy for AD treatment.
Human papillomavirus and oropharynx cancer: Biology, detection and clinical implications (2010)

HPV-associated squamous cell carcinoma of the oropharynx is a biologically distinct entity from carcinogen-associated carcinoma. Understanding the molecular mechanisms behind the improved outcomes in patients with HPV-associated oropharyngeal carcinoma may lead to novel therapeutics for patients with carcinogen-associated carcinomas.
Synergistic activities of combinations of antibiotics against methicillin-resistant Staphylococcus aureus. (1988)

The effect of an antibiotic combination against methicillin-resistant Staphylococcus aureus which is frequently found in hospitalized patients were investigated. By means of the microtiter checkerboard method, combinations of vancomycin-minocycline, vancomycin-cefamandole, vancomycin-fosfomycin, cefamandole-minocycline and cefamandole-fosfomycin were found to be synergistic against 6.4, 84.0, 20.9, 19.3 and 100.0% of the sixty-two strains tested, respectively. The means of the fractional inhibitory concentration (FIC) indices of vancomycin-minocycline, vancomycin-cefamandole, vancomycin-fosfmycin, cefamandole-minocycline and cefamandole-fosfomycin were 1.50, 0.39, 0.64, 0.85 and 0.25, respectively. Thus, the effect of the combination of cefamandole-fosfomycin was superior to other combinations.
A Bayesian Hierarchical Topic Model for Political Texts: Measuring Expressed Agendas in Senate Press Releases (2009)

Political scientists lack methods to efficiently measure the priorities political actors emphasize in statements. To address this limitation, I introduce a statistical model that attends to the structure of political rhetoric when measuring expressed priorities: statements are naturally organized by author. The expressed agenda model exploits this structure to simultaneously estimate the topics in the texts, as well as the attention political actors allocate to the estimated topics. I apply the method to a collection of over 24,000 press releases from senators from 2007, which I demonstrate is an ideal medium to measure how senators explain their work in Washington to constituents. A set of examples validates the estimated priorities and demonstrates their usefulness for testing theories of how members of Congress communicate with constituents. The statistical model and its extensions will be made available in a forthcoming free software package for the R computing language.
Molecular Tools To Study Preharvest Food Safety Challenges (2018)

Preharvest food safety research and activities have advanced over time with the recognition of the importance and complicated nature of the preharvest phase of food production. In developed nations, implementation of preharvest food safety procedures along with strict monitoring and containment at various postharvest stages such as slaughter, processing, storage, and distribution have remarkably reduced the burden of foodborne pathogens in humans. Early detection and adequate surveillance of pathogens at the preharvest stage is of the utmost importance to ensure a safe meat supply. There is an urgent need to develop rapid, cost-effective, and point-of-care diagnostics which could be used at the preharvest stage and would complement postmortem and other quality checks performed at the postharvest stage. With newer methods and technologies, more efforts need to be directed toward developing rapid, sensitive, and specific methods for detection or screening of foodborne pathogens at the preharvest stage. In this review, we will discuss the molecular methods available for detection and molecular typing of bacterial foodborne pathogens at the farm. Such methods include conventional techniques such as endpoint PCR, real-time PCR, DNA microarray, and more advanced techniques such as matrix-assisted layer desorption ionization-time of flight mass spectrometry and whole-genome sequencing.
Face Recognition as an Authentication Technique in Electronic Voting (2013)

In this research a Face Detection and Recognition system (FDR) used as an Authentication technique in online voting, which one of electronic is voting types, is proposed. Web based voting allows the voter to vote from any place in state or out of state. The voter’s image is captured and passed to a face detection algorithm (Eigenface or Gabor filter) which is used to detect his face from the image and save it as the first matching point. The voter’s National identification card number is used to retrieve and return his saved photo from the database of the Supreme Council elections (SCE) which is passed to the same detection algorithm (Eigenface or Gabor filter) to detect face from it and save it as second matching point. The two matching points are used by a matching algorithm to check wither they are identical or not. If the results of the matching algorithm are two point match then checks wither this person has the right to vote or not. If he has right to vote then a voting form is presented to him. The result shows that the proposed algorithm capable of finding over 90% of the faces in database and allows their voter to vote in approximately 58 seconds.
Helicobacter pylori protects oncogenically transformed cells from reactive oxygen species-mediated intercellular induction of apoptosis (2014)

Malignant transformation of gastric epithelial cells by chronic Helicobacter pylori infection is caused by several mechanisms including attraction of reactive oxygen species (ROS)-producing neutrophils and cytotoxin-associated antigen A-mediated dysplastic alterations. Here we show that H.pylori protects transformed cells from ROS-mediated intercellular induction of apoptosis. This potential control step in oncogenesis depends on the HOCl and NO/peroxynitrite (PON) signaling pathways. Helicobacter pylori-associated catalase and superoxide dismutase (SOD) efficiently cooperate in the inhibition of HOCl and the NO/PON signaling pathways. Helicobacter pylori catalase prevents HOCl synthesis through decomposition of hydrogen peroxide. Helicobacter pylori-associated SOD interferes with the crucial interactions between superoxide anions and HOCl, as well as superoxide anions and NO. The ratio of bacteria to malignant cells is critical for sufficient protection of transformed cells. Low concentrations of H.pylori more efficiently inhibited ROS-mediated destruction of transformed cells when compared with high concentrations of bacteria. Our data demonstrate the critical role of H.pylori antioxidant enzymes in the survival of transformed cells, modulating an early step of oncogenesis that is distinct from the transformation process per se.
Application of System Identification for Modeling the Dynamic Behavior of Axial Flow Compressor Dynamics (2017)

Identification of a one-stage axial compressor system is addressed. In particular, we investigate the underlying dynamics of tip air injection and throttle activation to the overall compressor dynamics and the dynamics around the tip of the compressor blades. A proposed subspace system identification algorithm is used to extract three mathematical models: relating the tip air injection to the overall dynamics of the compressor and to the flow dynamics at the tip of the compressor blade and relating the movement of the throttle to the overall compressor dynamics. As the system identification relays on experimental data, concerns about the noise level and unmodeled system dynamics are addressed by experimenting with two model structures. The identification algorithm entails a heuristic optimization that allows for inspection of the results with respect to unmodeled system dynamics. The results of the proposed system identification algorithm show that the assumed model structure for the system identification algorithm takes on an important role in defining the coupling characteristics. A new measure for the flow state in the blade passage is proposed and used in characterizing the dynamics at the tip of the compressor blade, which allows for the inspection of the limits for the utilized actuation.
Non‐motor Neuron System in Amyotrophic Lateral Sclerosis: Involvement of Clarke's Column and Intermediolateral Nucleus (1993)

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects the motor neuron system. However dose only the motor neuron system degenerate selectively in this disease? On the basis of histologic and morphometric studies on Clarke's column and intermediolateral nucleus (IML) neurons, which belong to the non‐motor neuron system in the spinal cord, we report in this Symposium presentation that in sporadic ALS, they are also primarily involved in the disease process. However, the rate of degeneration of these neurons is much slower than that of lower motor neurons. Our results indicate that Clarke's column neurons and IML neurons in the lower thoracic segments may start to disappear after the patients have begun to require respiratory support, which is the final stage of the natural hintory of the disease. In addition, it should also be empasized that Bunina bodies and spheroids are neuropathological features of Clarke's column in ALS patients, but not of the IML.
Reduction of Interleukin 8 Gene Expression in Reflux Esophagitis and Barrett's Esophagus With Antireflux Surgery (2007)

Interleukin 8 messenger RNA expression increases during the progression of reflux disease from normal squamous mucosa to esophageal adenocarcinoma. Elimination of reflux with Nissen fundoplication significantly reduces IL-8 expression in both squamous and Barrett's mucosa. These results demonstrate that effective antireflux surgery can modulate the gene expression of esophageal mucosa and may impact the natural history of reflux disease.
The ClpXP ATP-Dependent Protease Regulates Flagellum Synthesis in<i>Salmonella enterica</i>Serovar Typhimurium (2002)

The ClpXP protease is a member of the ATP-dependent protease family and plays a dynamic role in the control of availability of regulatory proteins and the breakdown of abnormal and misfolded proteins. The proteolytic activity is rendered by the ClpP component, while the substrate specificity is determined by the ClpX component that has ATPase activity. We describe here a new role of the ClpXP protease in Salmonella enterica serovar Typhimurium in which ClpXP is involved in the regulation of flagellum synthesis. Cells deleted for ClpXP show "hyperflagellate phenotype," exhibit overproduction of the flagellar protein, and show a fourfold increase in the rate of transcription of the fliC encoding flagellar filament. The assay for promoter activity of the genes responsible for expression of the fliC showed that the depletion of ClpXP results in dramatic enhancement of the expression of the fliA encoding sigma factor final sigma(28), leaving the expression level of the flhD master operon lying at the top of the transcription hierarchy of flagellar regulon almost normal. These results suggest that the ClpXP may be responsible for repressing the expression of flagellar regulon through the control of the FlhD/FlhC master regulators at the posttranscriptional and/or posttranslational levels. Proteome analysis of proteins secreted from the mutant cells deficient for flhDC and clpXP genes demonstrated that the DeltaflhD mutation abolished the enhanced effect by DeltaclpXP mutation on the production of flagellar proteins, suggesting that the ClpXP possibly defines a regulatory pathway affecting the expression of flagellar regulon that is dependent on FlhD/FlhC master regulators.
An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion (2018)

Thermobia domestica belongs to an ancient group of insects and has a remarkable ability to digest crystalline cellulose without microbial assistance. By investigating the digestive proteome of Thermobia, we have identified over 20 members of an uncharacterized family of lytic polysaccharide monooxygenases (LPMOs). We show that this LPMO family spans across several clades of the Tree of Life, is of ancient origin, and was recruited by early arthropods with possible roles in remodeling endogenous chitin scaffolds during development and metamorphosis. Based on our in-depth characterization of Thermobia's LPMOs, we propose that diversification of these enzymes toward cellulose digestion might have endowed ancestral insects with an effective biochemical apparatus for biomass degradation, allowing the early colonization of land during the Paleozoic Era. The vital role of LPMOs in modern agricultural pests and disease vectors offers new opportunities to help tackle global challenges in food security and the control of infectious diseases.
<title>Laser Rangefinder For Robot Control And Inspection</title> (1982)

Three-dimensional surface point data is often useful for r000t control and inspection casks. Tne design of sensors for collecting this data involves many choices, with selections made on tne oasis of data rate, accuracy, field of view, safety, size, object properties, and the need for registered range and orightness data. A sensor has been designed with data rates of 30 kHz for orightness, 2 kHz for range in the scanning mode, and 250 Hz for range in tne random access mode. Range data accuracy is aoout .1A of tne field of view. The main components of the sensor are a low power laser (1 mW), a 1024 element COD linear array camera, a galvanometer scanner, and a special interface to a minicomputer. Alternative designs include stereo without using projected energy, white light projection, ultrasound, time-of-flignt measurements, multiple detectors, projecting planes versus oeams, two-dimensional array cameras and "position" sensors, and a variety of scanning mechanisms.