gebhart/patrepeval huggingface dataset:
Mucopolysaccharidosis type <scp>III</scp> (<scp>S</scp>anfilippo syndrome) and misdiagnosis of idiopathic developmental delay, attention deficit/hyperactivity disorder or autism spectrum disorder (2013)

Children with developmental or speech delay, especially those with a characteristic somatic feature or behavioural abnormalities, should be screened for MPS III.
A Velocity Filter for Electrons and Ions (1926)

If a charged particle, moving along the $x$-axis with a velocity $v$, encounters successively two identical alternating electric fields of frequency $\ensuremath{\nu}$, which are everywhere perpendicular to the $x$-axis, it will emerge from the last field undisplaced and traveling in the original direction under the following conditions: (1) Each field has two similar halves whose distance between centers is $a$; (2) The distance between the fields, center to center, is $D=\frac{\mathrm{sa}}{n}$, where $s$ and $n$ are odd integers; (3) The velocity of the particle is ${v}_{0}=\frac{2a\ensuremath{\nu}}{n}$. The distribution about the velocity ${v}_{0}$ is computed when particles enter and leave the system through slits of width ${y}_{0}$ on the $x$-axis. The results show that the emergent beam can be confined to a verv narrow velocity range.Applications of the velocity filter.---Possible applications of the velocity filter, chiefly to positive ray work, are mentioned. It has already proved a successful and convenient substitute for pure magnetic analysis. It can be used to analyze a beam which is inhomogeneous both in mass and velocity when combined with either electric or magnetic deflection methods. The latter combination can be arranged to give a rigorously linear mass scale.
Video allocation methods in a multi-level server for large-scale VOD services (1998)

Although the characteristics of a hard disk are more suitable for the interactive environment of a VOD service, using hard disks as permanent storage devices can suffer from the relatively high cost and frequent failure rate of a hard disk. Several VOD servers with tertiary storage devices have been proposed but the response time for a user's request in most approaches is too long to be used in the interactive environment of a VOD service. This paper proposes another structure of a VOD server that utilizes the jukeboxes of optical disks for a video database. Since the jukeboxes of optical disks are more reliable and inexpensive, it is useful for storing the huge volume of video streams. as a result, it can be a part of a cost-effective server configuration for large-scale VOD services. Several allocation methods for video streams in the jukeboxes are devised and compared in order to improve the performance of the proposed structure.
A fixed-priority-driven open environment for real-time applications (2003)

This paper extends the useful concept of open systems proposed by W.S. Liu, et al. (1997) in scheduling real-time applications and non-real-time applications, where the schedulability of each real-time application can be validated independently of other applications in the system. We replace the underlying earliest-deadline-first OS scheduler of the open system architecture by W.S. Liu, et al. (1997) with a rate-monotonic OS scheduler. The motivation behind this work is that many existing operating systems may not support the earliest deadline first scheduling very well. We propose to use the idea of sporadic servers to preserve CPU cycles for applications. We also develop schedulability tests for real-time applications which adopt the rate monotonic scheduling algorithm, the earliest deadline first scheduling algorithm, the priority ceiling protocol, and the stack resource policy. We allow tasks in each application to share local and global non-preemptable resources. A global resource synchronization mechanism is proposed. This paper provides a fixed-priority-based alternative for the important open system architecture.
Complement deposition by antibodies to Pseudomonas aeruginosa mucoid exopolysaccharide (MEP) and by non-MEP specific opsonins (1991)

The failure of cystic fibrosis patients to limit chronic infection due to mucoid Pseudomonas aeruginosa might be due to ineffective opsonins produced against this bacterium. Nonopsonizing antibody to the bacterial capsule, mucoid exopolysaccharide (MEP), appears at elevated titers during chronic colonization of cystic fibrosis patients, as do opsonins not specific for MEP. Nonopsonic antibodies to MEP occur naturally in most adults and can be induced in animals by immunization. A limited number of humans produce MEP-specific opsonic antibodies after immunization. The purpose of this study was to compare the activation and deposition of C components onto the bacterial surface in the presence of these different antibodies. Opsonic killing uses the classical C pathway. MEP-specific opsonic and nonopsonic antibodies bound to whole bacteria and activated C to a comparable degree, but opsonic antibody deposited 3 to 40 times more C3 onto bacteria, mostly as C3bi, compared to nonopsonic antibody. In addition, two to three times as much nonopsonic mAb as opsonic mAb (both IgG2b) bound to the bacteria at comparable input concentrations, indicating the difference in C deposition was not due to differences in antibody binding. Non-MEP-specific opsonins also bound C3 to the bacteria, but only a mean of 27 +/- 14% was ester linked, compared with 81 +/- 11% of C3 deposited by MEP-specific opsonins. Immunoprecipitation experiments indicated that two-thirds of the C3 bound in the presence of MEP-specific opsonins was linked to MEP, whereas non-MEP-specific opsonins obtained from infected patients deposited the C3 onto LPS and other unidentified Ag. These data show that MEP-specific opsonins function by depositing C3 onto the outer bacterial surface that differentiates them from non-MEP-specific opsonins produced in response to chronic infection.
Managing the PSTN Transformation (2015)

While there are many scholarly books and papers that cover the technical issues behind the public switched telephone network (PSTN) migration, few books describe exactly how to manage the migration process economically. Filling this need, Managing the PSTN Transformation: A Blueprint for a Successful Migration to IP-Based Networks reflects the late
A high efficient LDMOS power amplifier based on an inverse class F architecture (2004)

A power amplifier based on the inverse Class F topology bas been developed. The design has been done at 1 GHz with an LDMOS transistor as an active element. The PAE and the drain eficiency of the power amplifier are 73.8% and 77.8% respectively at an output power of 12.4W. This is to our knowledge the highest efficiency and output power for an LDMOS-based inverse Class F power amplifier working at 1 GHz.
Testosterone as a Modulator of Vascular Behavior (2004)

Male sex is an acknowledged risk factor for many forms of cardiovascular disease, and vascular disease prevalence patterns appear to be different in men versus women. The vascular properties of the principal mammalian androgen, testosterone, are complex and linked to dose, duration of exposure, presence of underlying vascular disease, and, possibly, biological sex. Data from isolated vessels and animal models suggest that pharmacological doses of testosterone, or its potent intracellular metabolite dihydrotestosterone, produce vasodilation. Testosterone's major effect on vascular beds at physiologic concentrations remains unclear, with documentation of both vasodilatory and vasoconstrictive actions. Results of various studies suggest that testosterone can alter vascular tone through both endothelium-dependent and endothelium-independent mechanisms in a variety of vascular beds and vessel types. Testosterone's endothelium-dependent effects are likely mediated at least in part through nitric oxide (NO) elaboration, whereas mechanisms of endothelium-independent effects involve 1 or more types of smooth muscle ion conductance channels. Data from clinical studies indicate that, in men, androgen replacement may provide beneficial effects when coronary artery disease is present. Conversely, in women, testosterone may augment existing hypertension, increase risk for cardiovascular events, or promote atherogenesis. However, it should be emphasized that most of these observations are anecdotal or come from small-scale clinical studies, and limited information is available in women. New research is required to understand the potential efficacy of androgen therapy, or lack thereof. This review focuses on current understanding of testosterone's physiological effects on vascular behavior and of testosterone's putative role in vascular health and disease.
Sensor Network Based Oilwell Health Monitoring and Intelligent Control (2011)

Most oil pumping units (OPUs) have been using manual control in the oilfield. This existing oil-pumping system, a high power-consuming process, has the incapability of OPU's structural health monitoring. In this paper, a sensor network based intelligent control is proposed for power economy and efficient oilwell health monitoring. The proposed sensor network consists of three-level sensors: (1) several types of basic sensors, such as load sensor, angular sensor, voltage sensor, current sensor and oil pressure sensor, which are the first level sensors (FLS), are used for oilwell data sensing; (2) our developed intelligent sensors (IS), which belong to the second level sensor, are designed mainly for an oilwell's data elementary processing, main fault alarm/indication, typical data storage/indication, data/status transmission up to the third level sensor (TLS), data/status transmission between IS, and command transmission down to the OPU motor; and (3) our developed software-defined (SD) control centers with an embedded database, i.e., the TLS, are designed for hundreds of oilwells data storage/management, data processing, malfunction detection, malfunction alarm/indication, stroke-adjustment command transmission down to a specific IS for power economy and the malfunction report to the maintenance staff via global system for mobile communications (GSM) short message service (SMS). Experiment results at the Chinese Petroleum's Changqing Oilfield demonstrate our proposed sensor network based system.
Design and Biological Activity of (<i>S</i>)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency (2001)

The synthesis, structure-activity relationships, and biological properties of a novel series of imidazole-containing inhibitors of farnesyltransferase are described. Starting from a 3-aminopyrrolidinone core, a systematic series of modifications provided 5h, a non-thiol, non-peptide farnesyltransferase inhibitor with excellent bioavailability in dogs. Compound 5h was found to have an unusually favorable ratio of cell potency to intrinsic potency, compared with other known FTIs. It exhibited excellent potency against a range of tumor cell lines in vitro and showed full efficacy in the K-rasB transgenic mouse model.
The Nuclear-test-ban Act 1999 and Comprehensive Nuclear-test-ban Treaty 1996: The Environmental Protection Offered (2001)

Issues arising from New Zealand's Nuclear-Test-Ban Act 1999 and the extent to which the Act and the Comprehensive Nuclear-Test-Ban Treaty 1996 protect the environment are examined. The Act is merely a political pledge of affirmation of the Treaty and a fulfillment of its international obligation as New Zealand does not test nuclear weapons nor participate in such tests.
The Global Packing Number of a Fat-Tree Network (2017)

Data centers play an important role in today's Internet development. Research to find scalable architecture and efficient routing algorithms for data center networks has gained popularity. The fat-tree architecture, which is essentially a folded version of a Clos network, has proved to be readily implementable and is scalable. In this paper, we investigate routing on a fat-tree network by deriving its global packing number and by presenting explicit algorithms for the construction of optimal, load-balanced routing solutions. Consider an optical network that employs wavelength division multiplexing in which every user node sets up a connection with every other user node. The global packing number is basically the number of wavelengths required by the network to support such a traffic load, under the restriction that each source-to-destination connection is assigned a wavelength that remains constant in the network. In mathematical terms, consider a bidirectional, simple graph, G and let N ⊆ V(G) be a set of nodes. A path system P of G with respect to N consists of |N|(|N| -1) directed paths, one path to connect each of the source-destination node pairs in N. The global packing number of a path system P, denoted by Φ(G, N, P), is the minimum integer k to guarantee the existence of a mapping φ : P → (1, 2, ..., k), such that φ(P) ≠ φ(P̅) if P and P̅ have common arc(s). The global packing number of (G, N), denoted by Φ(G, N), is defined to be the minimum Φ(G, N, P) among all possible path systems ?. In additional to wavelength division optical networks, this number also carries significance for networks employing time division multiple access. In this paper, we compute by explicit route construction the global packing number of (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sub> , N), where T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sub> denotes the topology of the n-ary fat-tree network, and N is considered to be the set of all edge switches or the set of all supported hosts. We show that the constructed routes are load-balanced and require minimal link capacity at all network links.
Well-posedness of the Baumgarte-Shapiro-Shibata-Nakamura formulation of Einstein's field equations (2004)

We give a well posed initial value formulation of the Baumgarte-Shapiro-Shibata-Nakamura form of Einstein's equations with gauge conditions given by a Bona-Mass\'o--like slicing condition for the lapse and a frozen shift. This is achieved by introducing extra variables and recasting the evolution equations into a first order symmetric hyperbolic system. We also consider the presence of artificial boundaries and derive a set of boundary conditions that guarantee that the resulting initial-boundary value problem is well posed, though not necessarily compatible with the constraints. In the case of dynamical gauge conditions for the lapse and shift we obtain a class of evolution equations which are strongly hyperbolic and so yield well posed initial value formulations.
Should magnesium therapy be considered for the treatment of coronary heart disease? II. Epidemiological evidence in outpatients with and without coronary heart disease. (1994)

In an epidemiological and follow-up survey on 712 patients, 52 subjects with proven ischaemic heart disease were matched with and compared to 52 coronary-prone subjects with similar major cardiovascular risk factors (high-risk controls, HR) as well as to 52 patients at low cardiovascular risk (low-risk controls, LR). HR and LR patients were all free of overt ischaemic heart disease. Both the average daily dietary magnesium intake and the 24 h renal magnesium output were slightly higher in HR as compared to LR and ischaemic heart disease patients. No difference could be observed between the three groups with respect to serum magnesium levels, whereas erythrocyte magnesium levels were lower in ischaemic heart disease patients than in LR (P = 0.089) and to HR (P = 0.042). Ischaemic heart disease patients below 60 years had significantly lower erythrocyte magnesium levels than older (> 60 years) ischaemic heart disease patients. Lower erythrocyte magnesium levels in ischaemic heart disease patients were also associated with an increased incidence of cardiac events in the follow-up period and with a more unfavourable outcome. A pilot phase 6 month open trial of oral magnesium supplementation in nine ischaemic heart disease patients with low erythrocyte magnesium levels led to significant increases of erythrocyte magnesium in these patients, and to an impressive decrease of anginal attacks and nitrate consumption, as well as to a lesser degree of ST segment depression on surface ECG obtained at exercise testing in seven patients.
In-flight deflection measurement of the HiMAT aeroelastically tailored wing (1982)

An electro-optical flight deflection measurement system was developed for NASA for use on the highly maneuverable aircraft technology (HiMAT) remotely piloted research vehicle (RPRV) to provide a means of evaluating the performance of the HiMAT's aeroelastically tailored composite wing and canard. A description of the flight deflection measurement system is presented from a user's viewpoint and includes the general method of operation, system capabilities and limitations, method of installation on the HiMAT vehicle, and calibration of targets. Also included is a general description of the HiMAT RPRV and its design goals. Preliminary flight deflection and bending moment data were obtained at Mach 0.8 and were extrapolated to the Mach 0.9 maneuver design condition for comparison to NASTRAN predictions and ground loads test results. The preliminary flight test results tended to agree with the results obtained from the static ground loads tests, that is, that the NASTRAN model overpredicted the streamwise twist of the composite outer wing panel.
Chronic Effects of an Orally Active Selective Endothelin-B-Receptor Antagonist in Experimental Congestive Heart Failure (2000)

Endothelin-B- (ETB) receptors located in vascular beds mainly mediate vasorelaxation, however, long-term treatment with a mixed ETA/ETB receptor antagonist has been shown to improve the survival rate of rats with heart failure in a similar way to ETA-receptor inhibitors. The inhibition of ETB-receptor-mediated action should therefore be beneficial in preventing the deterioration seen in heart failure, despite various adverse hemodynamic effects. We administered K-8794 (Kowa Co. Ltd, Japan, 2mg/kg/day, n = 6), an orally active selective ETB-receptor antagonist, to dogs with heart failure induced by rapid right ventricular pacing for 14 days, commencing 8 days after pacing. Control dogs were given a placebo (n = 6). Mean arterial pressure decreased and systemic vascular resistance increased in both groups at the end of the protocol. In the K-8794 group, however, those values were higher than in the control group. Cardiac output decreased in both groups, but there were no significant differences observed between the two groups. Plasma renin activity and aldosterone increased in both groups at the end of the protocol, however levels in the K-8794 group were significantly lower than those in the control group. In the K-8794 group, it was quite interesting to note that Na excretion and urine flow rate were higher than in the control group. Our findings thus suggest that, although ETB-receptor antagonism produces some hemodynamic disadvantages, it can successfully prevent body fluid retention through the suppression the activation the renin-angiotensin-aldosterone system in dogs with heart failure.
Imaging Benign and Malignant Breast Lesions with Combined Optical Imaging and Tomosynthesis (2010)

We have imaged over 170 patients over the past 3 years with a combined optical and tomosynthesis imaging system. The region-of-interest analysis of 23 malignant lesions, 15 benign solid lesions and 8 cysts is reported.
The theory of scaling up laboratory data for the sedimentation type centrifuge (1959)

Abstract The mathematical theory of the sedimentation type of centrifuge is developed in terms of unhindered settling of a single particle that has reached equilibrium velocity. From this is derived the sigma value for several of the different forms of sedimentation type centrifuge which is the calculated equivalent area of a settling tank theoretically capable of doing the same amount of work in a unit gravitational field. The limitations controlling the accuracy of scale up between centrifuges of similar geometry and between centrifuges of substantially different geometry are discussed.
Neuroscience meets cryptography: designing crypto primitives secure against rubber hose attacks (2012)

Cryptographic systems often rely on the secrecy of cryptographic keys given to users. Many schemes, however, cannot resist coercion attacks where the user is forcibly asked by an attacker to reveal the key. These attacks, known as rubber hose cryptanalysis, are often the easiest way to defeat cryptography. We present a defense against coercion attacks using the concept of implicit learning from cognitive psychology. Implicit learning refers to learning of patterns without any conscious knowledge of the learned pattern. We use a carefully crafted computer game to plant a secret password in the participant’s brain without the participant having any conscious knowledge of the trained password. While the planted secret can be used for authentication, the participant cannot be coerced into revealing it since he or she has no conscious knowledge of it. We performed a number of user studies using Amazon’s Mechanical Turk to verify that participants can successfully re-authenticate over time and that they are unable to reconstruct or even recognize short fragments of the planted secret. 1
Time, space, and the new media machine of the terrorphone (2013)

In this short article, the author is concerned with how the contemporary form of the telephone, a new media machine which was of deep-rooted significance for Marshall McLuhan, promotes our obsession with forms of shared participation and social implosion. The author argues that the form of the telephone involves a complex abolition of our sense of space, interwoven with unexpected socio-cultural effects, which then create new subjectivities as well as new forms of decentralization that are intuited but not fully understood. To politicize these effects, and following the revelations of the American whistleblower Edward Snowden, the author identifies the form of the mobile telephone as a new form of media and argues that it is no longer an ‘extension of man’, as McLuhan suggested, but an extension of the US State, which is producing new forms of socio-cultural collapse. The author then explores how the remote-controlled time and space of what he calls the ‘terrorphone’ cultivates, among other things, the contemporary visualization of speech. Finally, he questions the desirability of unrelenting mobile telephone interaction as our only ‘intelligent’ choice today when such interaction is, contrary to McLuhan, not a great extension of our central nervous system, but in fact a danger to it.
An Execution Model of MAC on System Kernel for WiBro Access Terminal (2008)

The WiBro (wireless broadband) system is designed to be able to provide a variety of information and multimedia contents services through high speed wireless Internet access via various user terminals such as PC, PDA and hand-held PC. The WiBro system can be considered as a system that integrates services in wired-realm and a wireless service. The WiBro system consists of three major entities; WiBro-AT(Access terminal), WiBro-AP(Access Point) and PAR(Packet Access Router). WiBro-AT provides interface with users of WiBro service, it is the most important factor for successful launching and fast expansion of commercial WiBro service. In this paper, we present an execution model of MAC on system kernel for uplink packet transmission of WiBro Access Terminal. It uses tasklet and kernel thread for a data processing an it also uses circular queue for delayed function call of queue operation. It gives stable running of WiBro-AT in spite of non-atomic execution property of tasklet.