gebhart/patrepeval huggingface dataset:
One Gene Encoding Three Proteins with Different Functions (1991)

"One Gene Encoding Three Proteins with Different Functions." American Journal of Respiratory Cell and Molecular Biology, 5(1), pp. 1–3
The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers (1996)

The aim of the present clinical double-blind crossover study was to investigate the effect of two different toothpaste detergents, sodium lauryl sulfate (SLS) and cocoamidopropyl betaine (CAPB), as compared with a detergent-free paste, on 30 patients with frequent occurrences of recurrent aphthous ulcers. The study consisted of three 6-week periods during which the patients brushed twice daily with the different test toothpastes. The localization and number of new ulcers were assessed. A significantly higher frequency of aphthous ulcers was demonstrated when the patients brushed with an SLS- than with a CAPB-containing or a detergent-free placebo paste. An SLS-free toothpaste may thus be recommended for patients with recurrent aphthous ulcers.
A surface intersection algorithm based on loop detection (1991)

Article Free Access Share on A surface intersection algorithm based on loop detection Author: Michael E. Hohmeyer Computer Science Division, Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, California Computer Science Division, Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CaliforniaView Profile Authors Info & Claims SMA '91: Proceedings of the first ACM symposium on Solid modeling foundations and CAD/CAM applicationsMay 1991 Pages 197–207https://doi.org/10.1145/112515.112543Online:01 May 1991Publication History 9citation844DownloadsMetricsTotal Citations9Total Downloads844Last 12 Months15Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
The nucleotide sequence of the yeast<i>MEL1</i>gene (1985)

The complete nucleotide sequence of the MEL1 gene of the yeast, Saccharomyces cerevisiae, encoding alpha-galactosidase was determined. The nucleotide sequence contains an open reading frame of 1413 bp encoding a protein of 471 amino acids. Comparison with the known N-terminal amino acid sequence of the mature secreted protein indicated that alpha-galactosidase is synthesized as a precursor with an N-terminal signal sequence of 18 amino acids. The general features of this signal peptide resemble those of other yeast signal peptides. Molecular weight of the mature alpha-galactosidase polypeptide deduced from the nucleotide sequence is 50.049 kd. The 5' regulatory region has sequences in common with other yeast genes regulated by the GAL4-protein.
A System for Induction Heating of Large Steel Slabs (1970)

The fundamentals of induction heating, the basic heater design, its heating capabilities and characteristics, the power system, and a general arrangement of heaters designed to feed a large hot strip mill will be discussed.
Harmonium (2018)

We introduce Harmonium , a novel ultra wideband (UWB) RF localization architecture that achieves decimeter-scale accuracy indoors. Harmonium strikes a balance between tag simplicity and processing complexity to provide fast and accurate indoor location estimates. Harmonium uses only commodity components and consists of a small, inexpensive, lightweight, and FCC-compliant UWB transmitter or tag , fixed infrastructure anchors with known locations, and centralized processing that calculates the tag’s position. Anchors employ a new frequency-stepped narrowband receiver architecture that rejects narrowband interferers and extracts high-resolution timing information without the cost or complexity of traditional UWB approaches. In a complex indoor environment, 90% of position estimates obtained with Harmonium exhibit less than 31 cm of error with an average of 9 cm of inter-sample noise. In non-line-of-sight conditions (i.e., through-wall), 90% of position error is less than 42 cm. The tag draws 75 mW when actively transmitting, or 3.9 mJ per location fix at the 19 Hz update rate. Tags weigh 3 g and cost $4.50 USD at modest volumes. Furthermore, VLSI-based design concepts are identified for a simple, low-power realization of the Harmonium tag to offer a roadmap for the realization of Harmonium concepts in future integrated systems. Harmonium introduces a new design point for indoor localization and enables localization of small, fast objects such as micro quadrotors, devices previously restricted to expensive optical motion capture systems.
Lactams. XVII. Synthesis and stereochemical characterization of diethyl cis- and trans-5-ethyl-2-oxo-4-piperidinemalonate. (1979)

The Michael addition of diethyl malonate to 1-acetyl-3-ethyl-2, 3-dihydro-6 (1H)-pyridone (3) in EtOH at 55° has been found to give the trans isomer (4a) and the cis isomer (4b) of diethyl 5-ethyl-2-oxo-4-piperidinemalonate in a ratio of 85 : 15. The stereochemical assignments were based on C-13 nuclear magnetic resonance spectroscopic evidence as well as chemical interrelation with substances of known configuration. The latter included decarbethoxylation of 4a and 4b in dimethyl sulfoxide-H2O-NaCl to give the lactam monoesters 5a and 5b, conversion of 4a into trans-1-benzyl-5-ethyl-2-oxo-4-piperidinemalonic acid (7a) through the lactim ether 9a and its benzylated product 8a, debenzylation of 7a with sodium in liquid ammonia to give 6a, and alkaline hydrolysis of 4a to 6a.
Immunohistochemical Staining of Cytologic Smears With MIB-1 Helps Distinguish Low-Grade From High-Grade Neuroendocrine Neoplasms (2003)

Neuroendocrine neoplasms (NENs) of the lung and gastrointestinal tract constitute a pathologic and biologic spectrum of tumors. Accurate cytologic diagnosis of a neuroendocrine neoplasm is important since definitive treatment frequently is based on low-and high-grade categories without histologic sampling. In many instances, however, low- and high-grade NENs share cytologic features, hindering a precise classification. Since the histologic diagnostic criteria for separation of low- from high-grade categories can be based on the proliferation rate, we proposed to evaluate the usefulness of the immunocytochemical stain for the proliferation marker MIB-1 in the grading of NENs. Cytologic preparations of 63 NENs were retrieved from the files of Memorial Sloan-Kettering Cancer Center, New York, NY. One representative alcohol-fixed slide from each case was destained and restained immunocytochemically for MIB-1. When MIB-1 immunoreactivity was considered, all low-grade NENs showed immunoreactivity in fewer than 25% of the neoplastic cells, and all high-grade NENs demonstrated immunoreactivity in more than 50% of neoplastic cells. Our study demonstrates that MIB-1 dramatically stratifies NENs as low-grade or high-grade. Therefore, the proliferation index also correlates with grade of NEN in cytology specimens.
PROGRESSIVE OSTEOPOROSIS DURING ANDROGEN DEPRIVATION THERAPY FOR PROSTATE CANCER (2000)

Chemical or surgical castration in men with prostate cancer is usually followed by greatly accelerated bone loss which may be superimposed on a bone mass already depleted before hormonal therapy. Baseline bone mass and subsequent bone loss may be influenced by host obesity, age and exercise habits.
The improved efficacy of a fixed‐dose combination of fluticasone furoate and levocabastine relative to the individual components in the treatment of allergic rhinitis (2015)

These results suggest that once daily FF/LEVO FDC could provide a clinical therapeutic advantage to existing standard monotherapies in the treatment of moderate-to-severe AR, and support progression to evaluation in larger phase III clinical studies.
Meltblown Fabrics from Biodegradable Polymers (2001)

This paper describes the processing of biodegradable polymers in the meltblowing process. The processing of such materials is still in the development stages as their rheological behavior gives a strong restriction for such applications. Meltblowing experiments were carried out with different polymers, including polylactide, polyesteramide, polyvinylalcohol, cellulosediacetate and polycaprolactone/thermoplastic starch. The process of meltblowing requires lower molecular weight and narrow molecular weight distribution resins to produce uniform, fine-fiber webs. The polymer distribution is inversely proportional to the melt flow rate and directly related to the melt viscosity. The processing conditions and general observations will be explained. The physical properties and parameters such as fiber diameter, fiber diameter distribution and stress-strain properties of the webs were measured. Also, microscopical analysis of the meltblown fabric will be shown. These tests give first hints for the processability of such materials with the meltblown process.
Miglustat: Substrate Reduction Therapy for Lysosomal Storage Disorders Associated with Primary Central Nervous System Involvement (2006)

Difficulties with delivery of functional enzyme to the brain limit the ability to modify neurologic outcome in patients with neuronopathic forms of the lysosomal storage diseases. In a subset of these disorders, which result from a disruption of glycosphingolipid metabolism, the use of a small molecule inhibitor of substrate precursor synthesis may reduce the amount of brain tissue lipid deposition and lead to amelioration of disease. The efficacy of this approach, termed substrate reduction therapy, has been demonstrated in several animal models; with resultant reduction of ganglioside storage in the brain, delayed onset of symptoms and prolonged survival. This pre-clinical 'proof of therapeutic concept' served as the rationale for proceeding with trials in humans using miglustat; an imino-sugar inhibitor of ceramide-specific glucosytransferase (the catalyst for the first committed step in glycosphingolipid synthesis). The glycosphingolipidoses are rare 'orphan' disorders; the limited number of suitable study subjects and the paucity of information on the natural history of these disorders represent major hurdles in the conduct of clinical trials. As treatment potentially constitutes lifelong administration, there will be a need to identify any potential safety considerations attendant to the use of these agents. With greater understanding of disease mechanism, adjunctive therapies may be identified; offering the prospect of modifying these otherwise relentlessly progressive neurodegenerative diseases.
A spectrum- and power-efficient EHF mobile satellite system to be integrated with terrestrial cellular systems (1992)

An EHF satellite system for land-mobile applications to be integrated with a terrestrial cellular system is described. An approach to evaluate the carrier-to-cochannel interference occurring in multispot satellite coverage adopting frequency reuse is introduced, and results from the analysis are shown. Criteria for spectrum efficiency evaluation are also outlined along with traffic and link budget estimates. Possible options for payload implementation and mobile terminal design are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
EFFICIENT MAGNETIC LOCALIZATION AND ORIENTATION TECHNIQUE FOR CAPSULE ENDOSCOPY (2005)

To build a new wireless robotic capsule endoscope with external guidance for controllable and interactive GI tract examination, a sensing system is needed for tracking 3D location and 2D orientation of the capsule endoscope movement. An appropriate sensing method is to enclose a small permanent magnet in the capsule. The intensities of the magnetic field produced by the magnet in different spatial points can be measured by the magnetic sensors outside the patient's body. With the sensing data of magnetic sensor array, the 3D location and 2D orientation of the capsule can be calculated. Higher calculation accuracy can be obtained if more sensors and optimal algorithm are applied. In this paper, different nonlinear optimization algorithms were evaluated to solve the magnet's 5D parameters, e.g. Powell's, Downhill Simplex, DIRECT, Multilevel Coordinate Search, and Levenberg Marquardt method. We have found that Levenberg-Marquardt method provides satisfactory calculation accuracy and faster speed. Simulations were done for investigating the de-noise ability of this algorithm based on different sensor arrays. Also the real experiment shows that the results are satisfactory with high accuracy (average localization error is 5.6 mm).
Electron Paramagnetic Resonance Evidence for a Cysteine-Based Radical in Pyruvate Formate-lyase Inactivated with Mercaptopyruvate (1995)

Pyruvate formate-lyase (PFL) is a glycyl radical-containing enzyme that catalyzes the reversible, nonoxidative conversion of pyruvate and CoA into acetyl-CoA and formate. The radical is located on the alpha-carbon of glycine 734 and is required for catalysis. Two cysteine residues, C418 and C419, are also essential for catalysis. Mercaptopyruvate, a biologically relevant pyruvate analog, is shown here to be a mechanism-based inactivator of PFL. Upon addition of mercaptopyruvate to active PFL, an EPR spectrum is generated which exhibits components from two sulfur-based radicals. For one of these radicals, a disulfide radical, the hyperfine coupling to a single beta-methylene hydrogen is resolved in features at g = 2.057 and 2.023. The effects of deuterium labeling of the enzyme on the EPR spectrum for this species are consistent with the new radical being on a cysteine residue, probably cysteine 418 or 419. This spectrum is not formed upon addition of the inactivator to mutant enzymes, C418S and C419S, indicating that both active site cysteines are required for formation of the new radicals. The identity of the second species is also ascribed to be a sulfur-based radical on the basis of the EPR feature found at g = 2.01. Our results constitute the first direct evidence of sulfur-based radical formation in an enzyme. A mechanism for formation of the cysteine-based disulfide radical is proposed which requires the participation of the two active site cysteines as well as the glycyl radical.
Properties of ion implanted silicon, sulfur, and carbon in gallium arsenide (1970)

Abstract Work is described in which chromium-doped semi-insulating gallium arsenide has been successfully doped n-type with ion implanted silicon and sulfur, and p-type with ion implanted carbon. A dilute chemical etch has been employed in conjunction with differential Hall effect measurements to obtain accurate profiles of carrier concentration and mobility vs. depth in conductive implanted layers. This method has so far been applied to silicon-and sulfur-implanted layers in both Cr-doped semi-insulating GaAs and high purity vapor grown GaAs. In the case of sulfur implants, a strong diffusion enhancement has been observed during the annealing, presumably due to fast-diffusing, implantation-produced damage. Peak doping levels so far obtained are about 8 × 1017 electrons/cm3 for silicon implants and 2 × 1017 electrons/cm3 for sulfur implants. Mobility recovery has been observed to be complete except in regions near the surface which are heavily damaged by the implantation.
Isolation, Characterization, and Location of a Donor-Acceptor Unit from Cross-Linked Fibrin (1970)

The cross-linking systems of bovine and human fibrins were studied by the introduction of a radioactive substitute donor as an inhibitor of fibrin cross-linking, separation of the constituent polypeptide chains after sulfitolysis, and tryptic digestion of the labeled gamma-chains. The information gathered from this approach enabled us to isolate and characterize the complete donor-acceptor unit in tryptic digests of fibrin gamma-gamma cross-linked systems. In both bovine and human fibrin, this kind of cross-linking is accomplished by reciprocal bridging between overlapping carboxy-terminal segments of neighboring gamma-chains. The amino acid sequence of the carboxy-terminal heptadecapeptide of the bovine gamma-chain was determined and an alignment of the corresponding region of the human gamma-chain established.
The control of Asian rust by glyphosate in glyphosate‐resistant soybeans (2007)

These results demonstrate the disease control activities of glyphosate against rust diseases in GR wheat and GR soybeans.
Linear Gadolinium-Based Contrast Agents Are Associated With Brain Gadolinium Retention in Healthy Rats (2015)

Repeated administrations of the linear GBCAs gadodiamide, gadobenate dimeglumine, and gadopentetate dimeglumine to healthy rats were associated with progressive and significant T1 signal hyperintensity in the DCN, along with Gd deposition in the cerebellum. This is in contrast with the macrocyclic GBCA gadoterate meglumine for which no effect was observed.
Evaluation of soybean injury from sulfentrazone and inheritance of tolerance (1998)

Experiments were conducted in the field and greenhouse to evaluate the effects of cultivar and sulfentrazone rate on soybean injury and yield from soil-applied sulfentrazone and to determine soybean inheritance of sulfentrazone tolerance. Excessive rainfall and cool growing conditions in 1996 enhanced sulfentrazone injury and caused yield reduction in the susceptible cultivars ‘KS4895’ and ‘Hutcheson’ at 0.56 kg ai ha −1 and KS4895 at 0.42 kg ha −1 . Yields of tolerant cultivars ‘Deltapine 3478’ and ‘Manokin’ were not reduced. Sulfentrazone at 0.42 kg ha −1 reduced soybean stand 17 and 35% for tolerant and susceptible cultivars, respectively. Field and greenhouse inheritance studies were conducted on plant families developed from two crosses: Manokin (tolerant) by ‘Asgrow A4715’ (susceptible) and ‘Northrup King S59–60’ (tolerant) by KS4895 (susceptible). The sulfentrazone tolerance of Manokin and Northrup King S59–60 appeared to be controlled by a single gene, with tolerance being dominant to susceptibility. The allelic relationship of tolerance from these two sources needs to be determined.
Real time advertisement insertion in baseball video based on advertisement effect (2005)

In this paper, we propose a novel method to detect baseball video scene for commercial advertisement insertion. The method uses the criteria based on better advertisement effect to generate a set of rules. From these rules, proper timing (starting time and ending time) and location are identified to insert the advertisement in the broadcast baseball video automatically. The proper timing is detected based on the consistent existence of simple background objects in the video for a period of time. The proper location is identified by less-informative-region detection in the video. The rules make sure that the critical information of the video is not blocked by the advertisement and the advertisement is always stable, clear and viewable on the stationary background of the video. The experimental results are encouraging.
Impact of Cesarean Section on Neonatal Mortality Rates Among Very Preterm Infants in the United States, 2000–2003 (2008)

Cesarean section does seem to provide survival advantages for the most immature infants delivered at 22 to 25 weeks of gestation, independent of maternal risk factors for cesarean section.
Digital image velocimetry (1989)

A new technique, digital image velocimetry, is proposed for measurement of instantaneous velocity fields of time dependent flows. A time sequence of single-exposure images of seed particles are captured with a high speed camera, and the sampled images are then digitized on an image processor, enhanced, and superposed to construct a multiple-exposure image. Both the superposed image and a single-exposure image are digitally Fourier transformed for extraction of information on the velocity field. The new technique is designed to improve the flow measurement by eliminating some restrictions of existing optical methods such as laser speckle velocimetry and particle image velocimetry. These restrictions include the limited dynamic range of the velocity measurement, directional ambiguity of the velocity vector, and the difficulty of a real-time capability. The analysis and numerically simulated experiment show that improvement can be achieved with the new technique. Laboratory experiments are currently under investigation.
Tissue Engineering and Its Potential Impact on Surgery (2001)

The loss or failure of an organ or tissue is one of the most frequent, devastating, and costly problems in healthcare. Current treatment modalities include transplantation of organs, surgical reconstruction, use of mechanical devices, or supplementation of metabolic products. A new field, tissue engineering, applies the principles and methods of engineering, material science, and cell and molecular biology toward the development of viable substitutes which restore, maintain, or improve the function of human tissues. In this review, we outline the opportunities and challenges of this emerging interdisciplinary field and its attempts to provide solutions to tissue creation and repair. Within this context, we present our experience using the basic tools of tissue engineering to guide regeneration of diverse tissues that include the liver, small intestine, cardiovascular structures, nerve, and cartilage. And in addition, we discuss the necessity of finding new strategies to achieve vascularization of complex tissues for transplant and present our approaches utilizing MicroElectroMechanical Systems (MEMS) technology and three-dimensional printing.
Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity. (1981)

To assess the contribution to immunoglobulin heavy chain diversity made by recombination between variable region (VH) genes and joining region (JH) genes, we have determined the sequence of about 2000 nucleotides spanning the rearranged JH gene cluster associated with the VH gene expressed in plasmacytoma HPC76. The active VH76 gene has recombined with the second germ-line JH gene. The region we have studied contains two other JH genes, designated JH3 and JH4. No other JH gene was found within the region 1000 nucleotides downstream from JH4. Between JH3 and JH4 there is a pseudo-JH sequence with substantial homology to the authentic JH genes. The four JH genes whose sequences now are known can account for all known JH amino acid sequences. The JH genes are more divergent than the Jk genes and vary in length, encoding either 15 or 17 amino acid residues. Because JH regions comprise part of the third hypervariable region (HV3), combinatorial VH--JH joining substantially augments VH diversity. Moreover, a VH gene can recombine with each JH gene at several positions, and either one or two germ-line JH codons can be excised. This JH truncation markedly reduces the length of HV3 and hence must alter antigen-binding specificity. We have also determined the sequence of the JH4 region in two different gamma 2a mRNAs and have found that each has suffered a point mutation (aspartate to asparagine) which would alter the charge of the antigen-binding site.