gebhart/patrepeval huggingface dataset:
BET Protein Inhibition Prolongs Cardiac Transplant Survival via Enhanced Myocardial Autophagy (2020)

JQ1 prolonged cardiac allograft survival by potentiating myocardial autophagy through the liver kinase beta 1-AMP-activated protein kinase-ULK1 signaling pathway and inhibiting the subsequent release of inflammatory cytokines. This result might provide novel insights for extending transplant survival.
Transplantation of Bone Marrow Cells Reduces Ccl4–Induced Liver Fibrosis in Mice (2004)

We investigated the effect of bone marrow cell (BMC) transplantation on established liver fibrosis. BMCs of green fluorescent protein (GFP) mice were transplanted into 4-week carbon tetrachloride (CCl4)-treated C57BL6 mice through the tail vein, and the mice were treated for 4 more weeks with CCl4 (total, 8 weeks). Sirius red and GFP staining clearly indicated migrated BMCs existing along with fibers, with strong expression of matrix metalloproteinase (MMP)-9 shown by anti-MMP-9 antibodies and in situ hybridization. Double fluorescent immunohistochemistry showed the expression of MMP-9 on the GFP-positive cell surface. Film in situ zymographic analysis revealed strong gelatinolytic activity in the periportal area coinciding with the location of MMP-9-positive BMCs. Four weeks after BMC transplantation, mice had significantly reduced liver fibrosis, as assessed by hydroxyproline content of the livers, compared to that of mice treated with CCl4 alone. Subpopulation of Liv8-negative BMCs was responsible for this fibrolytic effect. In conclusion, mice with BMC transplants with continuous CCl4 injection had reduced liver fibrosis and a significantly improved survival rate after BMC transplantation compared with mice treated with CCl4 alone. This finding introduces a new concept for the therapy of liver fibrosis.
AC Versus DC Microgrid Planning (2015)

This paper presents a microgrid planning model for determining the optimal size and the generation mix of distributed energy resources (DERs), as well as the microgrid type, i.e., ac or dc. Considering the growing ratio of dc loads and DERs, dc microgrids could be potentially more beneficial than ac microgrids by avoiding the need to synchronize generators, reducing the use of converters, facilitating the connection of various types of DERs and loads to the microgrid common bus with simplified interfaces, and reducing losses associated with the ac-dc energy conversion. The microgrid type is selected based on economic considerations, where the planning objective includes the investment and operation costs of DERs, cost of energy purchase from the main grid, and the reliability cost. Numerical simulations exhibit the effectiveness of the proposed model and investigate in detail the impact of variety of factors on planning results, including the ratio of critical loads, the ratio of dc loads, and the efficiency of inverters and converters.
Inner Ear Therapy for Neural Preservation (2006)

A gradual loss of auditory neurons often occurs following sensorineural hearing loss. Since the cochlear implant must stimulate the remaining auditory neuron population, it would be beneficial to preserve as many auditory neurons as possible. Neurotrophic factors protect auditory neurons from degradation after sensorineural hearing loss in experimental animals, but have not yet been translated into the clinical setting. Current experimental and clinical techniques for drug delivery to the inner ear are examined in this review, covering the routes for drug delivery to the cochlea and the delivery systems used to introduce them. Duration of treatment, drug diffusion, effectiveness and safety are discussed with references to how they may be translated to the implementation of neurotrophic factor treatment for neural preservation.
Stereochemistry of Complexes Based on Metal Tetrafluorides (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of Complexes Based on Metal TetrafluoridesE. L. MuettertiesCite this: J. Am. Chem. Soc. 1960, 82, 5, 1082–1087Publication Date (Print):March 1, 1960Publication History Published online1 May 2002Published inissue 1 March 1960https://pubs.acs.org/doi/10.1021/ja01490a018https://doi.org/10.1021/ja01490a018research-articleACS PublicationsRequest reuse permissionsArticle Views312Altmetric-Citations128LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The effect of dexamethasone on electroencephalograms in patients with brain tumors (1978)

Nine patients with primary or metastatic brain tumors were examined with topographic computer display of delta activity before and after administration of dexamethasone. In six cases with primary malignant or metastatic brain tumors a diminution of delta distribution was observed following intravenous administration of dexamethasone, and no significant changes of the topographic map of the delta wave were obtained in two cases of benign brain tumor without clinical signs of increased intracranial pressure. Some of the changes of delta activities are believed to be correlated with the amount of peritumor edema. It is noteworthy that the change of focal delta activities by steroid was detected 20 minutes after administration.
Stability of the perpendicular magnetic anisotropy of ultrathin Ni films on Cu(100) upon multiple magnetization reversals (2001)

Ultrathin Ni films with perpendicular magnetic anisotropy were deposited on Cu(100) at room temperature. The magnetic properties of the films were measured upon multiple magnetization reversals in an alternating magnetic field using the magneto-optic Kerr effect. All magnetic properties remain virtually constant for up to ${10}^{6}$ magnetization reversals for all films studied. This finding is supported by a simple theoretical model.
Lattice decoding can achieve 1/2 log(1+SNR) on the AWGN channel using nested codes (2002)

We demonstrate that using dithering techniques the power constrained AWGN channel can be transformed into a module lattice additive noise channel, effectively increasing the SNR by one. This allows lattice decoding to be optimal for SNRs for which a pair of "good" nested lattices exist.
Urinary tract infection in renal transplant recipients (2008)

Urinary tract infection (UTI) is common in renal transplant recipients. Frequency of UTIs depend on many factors such as age, female gender, kidney function, co-morbidity, type and amount of immunosuppression, urological instrumentation and/or the follow-up period (short term or long term) after kidney transplantation. UTI may worsen graft and patient survival. A significant proportion of renal transplant recipients with UTIs may develop acute pyelonephritis (APN), which is an independent risk factor for deterioration of graft function. Renal transplant recipients with UTIs are often clinically asymptomatic as a consequence of immunosuppression. UTI, however, may progress to APN (particularly in the early post-transplant period), bacteraemia and the full blown picture of urosepsis. Strategies for long term prophylaxis and antimicrobial treatment of UTI in renal transplant recipients are discussed.
Growth of Few‐Layer Graphene on a Thin Cobalt Film on a Si/SiO<sub>2</sub> Substrate (2011)

Few‐layered sheets of graphene were synthesized on polycrystalline thin Co and Ni films by low pressure chemical vapor deposition. On average, thinner layers of graphene were synthesized on Co than on the conventional Ni at the same process conditions, but slightly higher defects were detected on Co‐grown graphene layers than on Ni‐grown ones. Possible explanations for this are suggested.
Empirical test of Vaillant's hierarchy of ego functions (1982)

Vaillant (I , 2) hypothesized a four-level hierarchy of ego functions based on psychoanalytic psychology. The first, most disturbed level comprises the ‘ ‘narcissistic” (1) or “psychotic” (2) mechanisms ofdenial of reality, delusional projection, and distortion. The second level is characterized by ‘ ‘immature’ ‘ mechanisms: schizoid fantasy, projection, hypochondniasis, passive-aggressive behavior, and acting out. The third level is characterized by the ‘ ‘neurotic’ ‘ mechanisms of intellectualization, repression, reaction formation, displacement, and dissociation. The fourth, most healthy level comprises ‘ ‘mature’ ‘ mechanisms: sublimation, altruism, suppression, anticipation, and humon.
PowerDEVS: a tool for hybrid system modeling and real-time simulation (2010)

In this paper we introduce a general-purpose software tool for discrete event system specification (DEVS) modeling and simulation oriented to the simulation of hybrid systems. The environment, called PowerDEVS, allows atomic DEVS models to be defined in C++ language that can then be coupled graphically in hierarchical block diagrams to create more complex systems. The environment automatically translates the graphically coupled models into a C++ code which executes the simulation. A remarkable feature of PowerDEVS is the possibility to perform simulations under a real-time operating system (RTAI) synchronizing with a real-time clock, which permits the design and automatic implementation of synchronous and asynchronous digital controllers. Combined with its continuous system simulation library, PowerDEVS is also an efficient tool for real-time simulation of physical systems. Another feature is the interconnection between PowerDEVS and the numerical package Scilab. PowerDEVS simulations can make use of Scilab workspace variables and functions, and the results can be sent back to Scilab for further processing and data analysis. In addition to describing the main features of the software tool, the article also illustrates its use with some examples which show its simplicity and efficiency.
Cell-Specific Gene Expression in Langerhans Cell Histiocytosis Lesions Reveals a Distinct Profile Compared with Epidermal Langerhans Cells (2010)

Langerhans cell histiocytosis (LCH) is a rare disease characterized by heterogeneous lesions containing CD207(+) Langerhans cells (LCs) and lymphocytes that can arise in almost any tissue and cause significant morbidity and mortality. After decades of research, the cause of LCH remains speculative. A prevailing model suggests that LCH arises from malignant transformation and metastasis of epidermal LCs. In this study, CD207(+) cells and CD3(+) T cells were isolated from LCH lesions to determine cell-specific gene expression. Compared with control epidermal CD207(+) cells, the LCH CD207(+) cells yielded 2113 differentially expressed genes (false discovery rate < 0.01). Surprisingly, the expression of many genes previously associated with LCH, including cell-cycle regulators, proinflammatory cytokines, and chemokines, were not significantly different from control LCs in our study. However, several novel genes whose products activate and recruit T cells to sites of inflammation, including SPP1 (osteopontin), were highly overexpressed in LCH CD207(+) cells. Furthermore, several genes associated with immature myeloid dendritic cells were overexpressed in LCH CD207(+) cells. Compared with the peripheral CD3(+) cells from LCH patients, the LCH lesion CD3(+) cells yielded only 162 differentially regulated genes (false discovery rate < 0.01), and the expression profile of the LCH lesion CD3(+) cells was consistent with an activated regulatory T cell phenotype with increased expression of FOXP3, CTLA4, and SPP1. Results from this study support a model of LCH pathogenesis in which lesions do not arise from epidermal LCs but from accumulation of bone marrow-derived immature myeloid dendritic cells that recruit activated lymphocytes.
Catalyst electrode specific for peroxide (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalyst electrode specific for peroxideStuart J. Updike, Mark C. Shults, Judy K. Kosovich, Isabel. Treichel, and Paul M. TreichelCite this: Anal. Chem. 1975, 47, 8, 1457–1459Publication Date (Print):July 1, 1975Publication History Published online1 May 2002Published inissue 1 July 1975https://pubs.acs.org/doi/10.1021/ac60358a011https://doi.org/10.1021/ac60358a011research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CD27 mediates interleukin-2-independent clonal expansion of the CD8 <sup>+</sup> T cell without effector differentiation (2006)

The clonal expansion of antigen-specific CD8+ T cells in response to microbial infections is essential for adaptive immunity. Although IL-2 has been considered to be primarily responsible for this process, quantitatively normal expansion occurs in the absence of IL-2 receptor signaling. Here, we show that ligating CD27 on CD8+ T cells that have been stimulated through the T cell receptor causes their expansion in the absence of IL-2 by mediating two distinct cellular processes: enhancing cell cycling and promoting cell survival by maintaining the expression of IL-7 receptor alpha. This pathway for clonal expansion of the CD8+ T cell is not associated with the development of a capacity either for production of IFN-gamma or for cytotoxic T lymphocyte function and, therefore, is uncoupled from differentiation. Furthermore, ligating CD27 increases the threshold concentration at which IL-2 induces IFN-gamma-producing capability by the CD8+ T cell, suggesting that CD27 signaling may suppress effector differentiation. Finally, CD8+ T cells that have been stimulated by the TCR/CD27 pathway maintain their capacity for subsequent expansion and effector differentiation in response to a viral challenge in vivo. Thus, the TCR/CD27 pathway enables the CD8+ T cell to replicate by a process of self-renewal, which may contribute to the continuous generation of new effector CD8+ T cells in persistent viral infections.
A New Mechanism to Incorporate Network Coding Into TCP in Multi-radio Multi-channel Wireless Mesh Networks (2011)

Most of the approaches in the application of network coding either require the overhearing opportunity or have bad interaction with TCP. A new mechanism, named TCP-I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> NC, is proposed in this paper to incorporate network coding into TCP in interference-free multi-radio multi-channel wireless mesh networks where there are nearly no overhearing opportunities. Multiple TCP flows are coded together and forwarded in block by hop-by-hop ACK and retransmissions in TCP-I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> NC. Several encoding blocks are working simultaneously to effectively utilize available bandwidth. However the maximum of encoding blocks is adaptively adjusted according to the bandwidth, propagation delay and packet loss rate of a wireless link, and also back pressure algorithm is used to perform flow and scheduling control. The end-to-end delay is optimized so that TCP-I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> NC is applicable to delay-sensitive applications. Simulations show that our mechanism both significantly improves the throughput of TCP and derives a relatively short end-to-end delay as losses increase. And the delay jitter of TCP-I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> NC is also very small. TCP-I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> NC also achieves complete fairness in resource allocation.
Polar Acetylenic Liquid Crystals with Broad Mesomorphic Ranges. The Positional Influence of Different<i>C</i>,<i>C</i>-Elements on the Transition Temperatures (1984)

Abstract Various mesogenic nitriles with inserted dimethylene, trans-vinylene and especially ethynylene units at different positions in the structures of typical nematogens have been prepared and examined with regard to their transition temperatures. The thermal stabilities of the mainly nematic phases for these new compounds were compared with those for the corresponding nitriles lacking these C, C-elements. Nematic thermal efficiency orders are given.
SU-E-T-593: Evaluation of Titanium Applicator Reconstruction Accuracy for Exclusive 3.0 Tesla MRI-Guided Brachytherapy for GYN Cancers (2011)

Purpose: To evaluate applicator reconstruction accuracy using titanium tandem-and-ovoids applicator (TnO) when guided exclusively by high resolution (3 Tesla) MRI. Methods: MRI-marker catheters (Vitamin-E) are made in-house. A titanium Fletcher-Suit-Delclos-style TnO (Varian) was used. Nineteen HDR plans were randomly selected and TnO was reconstructed exclusively on MRI using the guidance from an applicator library (Solid Applicator, Varian) and a MRI-marker. For control, TnO reconstructions were retrospectively performed on two radiographs before and after the MR scan (pre- and post-Xray). The vector distances (d) were measured between each dwell position and a flenge. The differences of d (delta-d) on the reconstructions between of MRI and of pre-Xray (preXray- MRI) and between of MRI and post-Xray (MRI-postXray) were measured. The delta-d values were used to quantify the reconstruction uncertainty on exclusive MrIGBT. The average (± std dev) of delta-d for each dwell position was determined for each TnO plan. Results: We found on average delta-d = 0.8 ± 0.5 mm (1.0 ± 0.5 mm) for preXray-MRI (MRI-postXray). The values of delta-d were on average 0.9 ±0.1 mm and 0.8 ± 0.3 mm (1.0 ± 0.2 mm and 0.9 ± 0.4 mm) at tandem and ovoids for MRI-preXray (MRI- postXray). The ovoid shape available for use from the applicator library was found to be beneficial, since the MRI-marker could not generate signals for the ovoids. However, two cases showed delta-d = more than 2 mm. The largest delta-d values were on average 3.7 ± 0.3 mm (3.2 ± 0.8 mm) at tandem for preXray-MRI (MRI-postXray). Therefore, further studies on better MRI-marker designs are expected to be followed for exclusive MrIGBT. Conclusions: The reconstruction uncertainties for exclusive MrIGBT using titanium applicators were on average less than 1.0 mm but exceeded 3.7 mm in one case. The first author, Yusung Kim, has been performed a research with the collaboration grant from Varian (Medical System; $124,160.42 Jan 2011 – July 2012).
Middle Atmosphere Measurements of Small-Scale Electron Density Irregularities and Ion Properties During the MAC/Epsilon Campaign (1989)

Rocket payloads designed to measure small scale electron density irregularities and ion properties in the middle atmosphere were flown with each of the three main salvos of the MAC/Epsilon campaign conducted at the Andoya Rocket Range, Norway, during October to November 1987. Fixed bias, hemispheric nose tip probes measured small scale electron density irregularities, indicative of neutral air turbulence, during the rocket's ascent; and subsequently, parachute-borne Gerdien condensers measured the region's polar electrical conductivity, ion mobility and density. One rocket was launched during daylight (October 15, 1052:20 UT), and the other two launches occurred at night (October 21, 2134 UT: November 12, 0021:40 UT) under moderately disturbed conditions which enhanced the detection and measurement of turbulence structures. A preliminary analysis of the real time data displays indicates the presence of small scale electron density irregularities in the altitude range of 60 to 90 km. Ongoing data reduction will determine turbulence parameters and also the region's electrical properties below 90 km.
Depletion of G9a gene induces cell apoptosis in human gastric carcinoma (2016)

G9a is a mammalian histone methyltransferase that contributes to the epigenetic silencing of tumor suppressor genes. Evidence suggests that G9a is required to maintain the malignant phenotype, but little documentation show the role of G9a function in mediating tumor growth. We retrospectively analyzed the protein of G9a and monomethylated histone H3 lysine 9 (H3K9 me1), and dimethylated histone H3 lysine 9 (H3K9 me2) in 175 cases of gastric carcinoma by immunohistochemistry. RNAi-based inhibition of G9a in MGC803 cancer cell line was studied. G9a depletion was done by transient transfection using Lipofectamine 2000. Depletion efficiency of G9a was tested using real-time PCR and western blot analysis. Cell apoptosis and proliferation were detected by TUNEL assay and MTT, respectively. The proteins of H3K9 me1, me2, trimethylation of H3K9 (H3K9 me3), monomethylated histone H3 lysine 27 (H3K27 me1), dimethylated histone H3 lysine 27 (H3K27 me2) and histone acetylated H3, apoptotic proteins were studied by western blot analysis. G9a and H3K9 me2 expression was higher in gastric cancer cells compared to the control (p<0.05). Both G9a and H3K9 me2 were positively correlated with the degree of differentiation, depth of infiltration, lymphatic invasions and tumor-node-metastasis stage in gastric carcinoma, (p<0.05). RNAi-mediated knockdown of G9a induced cell apoptosis and inhibited cell proliferation. Depletion of G9a reduced the levels of H3K9 me1 and me2, H3K27 me1 and me2. Nonetheless, it did not activate acetylation of H3 and H3K9 me3. These data suggest that G9a is required in tumorigenesis, and correlated with prognosis. Furthermore, G9a plays a critical role in regulating epigenetics. Depletion of G9a inhibits cell growth and induces cells apoptosis in gastric cancer. It might be of therapeutic benefit in gastric cancers.