gebhart/patrepeval huggingface dataset:
Smoothing of Diamond-Turned Copper Surfaces Using Ion Beams with Aid of Planarizing Film (2007)

We investigate ion beam etching that uses a planarizing film for smoothing copper surfaces with nm-order roughness. Copper surfaces were cut using a turning machine with a single-crystal diamond tool to prepare mirror surfaces as workpieces. Then, the surfaces were coated with photoresist, and etched using ion beams with an appropriate incidence angle. As a result, tool marks exhibited on the turned surfaces were removed, and the surfaces with a smoothness of nm order were further improved by the ion beam process.
High salt activation of recA protein ATPase in the absence of DNA. (1988)

The recA protein of Escherichia coli is a DNA-dependent ATPase. In the absence of DNA, the rate of recA protein-promoted ATP hydrolysis drops 2000-fold, exhibiting an apparent kcat of approximately 0.015 min-1. This DNA-independent activity can be stimulated to levels approximating those observed with DNA by adding high concentrations (approximately 2M) of a wide variety of salts. The increase in ATP hydrolysis appears to require the minimal interaction of three to four ions with recA protein. The active species in ATP hydrolysis is an aggregate of recA protein. There appears to be little or no cooperativity with respect to ATP binding (Hill coefficient = 1.0). The salt-stimulated ATP hydrolysis reaction is dependent upon Mg2+ ions and is optimal between pH 7.0 and 8.0. In many respects, the high salt concentration appears to be functionally mimicking DNA in activating the recA protein ATPase.
MobilisGroups: Location-based group formation in Mobile Social Networks (2011)

Location restrictions in Mobile Social Networks are often used to realize the notion of places as well as for proximity-based friend or interest matching. In this work, we extend this by the ability to create and manage groups with location and time restrictions regarding their visibility and ability to be joined. Its main contribution is the design and reference implementation of the reusable MobilisGroups service as part of the Mobilis platform, an XMPP-based service environment for developers of mobile social software. Location-based group formation furthermore links the physical and the virtual world by creating incentives to be at a certain place at a certain time and complements the two approaches mentioned above.
Physical and Biological Studies of Coal and Oil Fly Ash (1983)

Studies were performed to compare the physical and chemical characteristics and the in vitro macrophage cytotoxicity of oil and coal fly ash. Sampling methodology was developed to collect size-fractionated particulate matter from the smokestack of either a coal-fired or an oil-fired power plant. Morphological studies demonstrated particle heterogeneity, although most coal fly ash particles appeared to be spherical. Oil fly ash contained two major morphologies; nonopaque amorphous particles and opaque amorphous particles. Elemental analysis indicates that the coal ash is predominantly composed of aluminosilicate particles, while the oil ash is predominantly inorganic sulfates and carbonaceous particles. In vitro macrophage assays demonstrate that the finest coal fly ash particles are the most cytotoxic; the cytotoxicity is significantly less than that of alpha-quartz, the positive control particle. In contrast, the oil fly ash particles are more cytotoxic than quartz. The cytotoxicity of oil fly ash is due to soluble components, possibly vanadium salts.
DYNAMIC MODELING AND GAIN SCHEDULING CONTROL OF A CHIILLED WATER COOLING SYSTEM (2014)

A dynamic model of a Chilled Water (ChW) cooling system with a stratified ChW tank was developed. A PI-based Gain Scheduling (GS) control strategy was designed to improve thermal performance of the chiller system. Five different operation strategies were simulated and the energy consumption and cost of operating the system under full load and partial load conditions were compared. The results showed that the operating strategy with optimized chilled water set point saved 7.16% energy (21.5% cost) compared to the case with constant set point under full load conditions. These savings were more significant (8.5% energy and 36% cost) under partial load conditions.
A control kernel to support ada intertask communication on a distributed multiprocessor computer system (1982)

The control kernel software necessary to support the execution of the Ada intertask communication primitives on a distributed multiprocessor computer system is described. The control kernel software has been written in a high-level procedural language. It is therefore portable, and represents part of a run-time support environment for a concurrent programming language known as Martlet. Martlet combines the tasking features of Ada with the sequential features of the language Pascal. The choice between master-slave and separate autonomous kernels in a multiprocessor system is analysed, and the required data structures and associated routines used in an actual implemented system are described. Finally, the mechanism of mapping interrupts into external entry calls is presented
Heart Rate Variability and Spontaneous Baroreflex Sequences: Implications for Autonomic Monitoring During Hemorrhage (2005)

Analysis of heart rate variability and baroreflex sequences in hemorrhaging patients may provide advance recognition of those at risk for progression to shock. In conjunction with more traditional modes of assessing volume status, tracking early changes in autonomic function may improve resuscitation efforts for the hemodynamic compromised patient.
Ontogeny of the Kidney and Renal Developmental Markers in the Rhesus Monkey (<i>Macaca Mulatta</i>) (2010)

Nonhuman primates share many developmental similarities with humans, thus they provide an important preclinical model for understanding the ontogeny of biomarkers of kidney development and assessing new cell-based therapies to treat human disease. To identify morphological and developmental changes in protein and RNA expression patterns during nephrogenesis, immunohistochemistry and quantitative real-time PCR were used to assess temporal and spatial expression of WT1, Pax2, Nestin, Synaptopodin, alpha-smooth muscle actin (α-SMA), CD31, vascular endothelial growth factor (VEGF), and Gremlin. Pax2 was expressed in the condensed mesenchyme surrounding the ureteric bud and in the early renal vesicle. WT1 and Nestin were diffusely expressed in the metanephric mesenchyme, and expression increased as the Pax2-positive condensed mesenchyme differentiated. The inner cleft of the tail of the S-shaped body contained the podocyte progenitors (visceral epithelium) that were shown to express Pax2, Nestin, and WT1 in the early second trimester. With maturation of the kidney, Pax2 expression diminished in these structures, but was retained in cells of the parietal epithelium, and as WT1 expression was upregulated. Mature podocytes expressing WT1, Nestin, and Synaptopodin were observed from the mid-third trimester through adulthood. The developing glomerulus was positive for α-SMA (vascular smooth muscle) and Gremlin (mesangial cells), CD31 (glomerular endothelium), and VEGF (endothelium), and showed loss of expression of these markers as glomerular maturation was completed. These data form the basis for understanding nephrogenesis in the rhesus monkey and will be useful in translational studies that focus on embryonic stem and other progenitor cell populations for renal tissue engineering and repair.
PKI-Based E-Business Security System (2008)

When e-business changing people's business model, security has also become the focus the people attended increasingly. PKI (public key infrastructure) is the key technology to ensure the network security. In this paper, the composition of the PKI and architecture are minutely analyzed, the PKI-based e-business security system is established from the basic process of ebusiness activities, and the security of the system is analyzed, finally the system is implemented.
Chemotherapy in Advanced Non-Small Cell Lung Cancer (2005)

Although patients with advanced non-small cell lung cancer (NSCLC) cannot be cured, cytotoxic chemotherapy in patients with reasonable performance status can improve overall survival and quality of life. No one regimen has demonstrated superior efficacy results, and platinum-based doublets remain the current standard of care. The toxicity profiles of acceptable regimens differ, allowing treatment to be tailored to a specific patient. The duration of first-line chemotherapy should not exceed four to six cycles. Second- and third-line treatment regimens also have established survival benefits, which has led to increasing improvements in overall survival for patients with advanced NSCLC. Treatment approaches in patients with borderline performance status remain controversial. Although the optimal treatment approach for elderly patients has not yet been established, it is clear that the elderly do benefit from chemotherapy, and fit elderly patients can be treated with the same regimens as younger patients. It is critical that all patients with advanced NSCLC be referred to medical oncologists. Patients considering chemotherapy must have a clear understanding of the expected benefits, limitations, and toxicities.
Myocardial Ultrastructure in Idiopathic Hypertrophic Subaortic Stenosis (1972)

Electron microscopic studies revealed distinctive abnormalities in operatively resected myocardium from the left ventricular outflow tract in 14 patients with idiopathic hypertrophic subaortic stenosis. Bundles of muscle cells were severely disorganized, with cells running in different directions instead of in parallel. Muscle cells were wider and shorter than in hypertrophy due to other causes and showed increased cellular branching, extensive side-to-side intercellular junctions, widened Z bands, and evidence of formation of new sarcomeres. Some myofibrils were oriented obliquely or perpendicular to the longitudinal axes of the cells and some myofilaments that originated from a single Z band inserted into Z bands of other myofibrils. Examination of left ventricular apical myocardium in two patients revealed hypertrophied but normally arranged muscle cells. It is concluded that abnormal architecture of muscle cells is the basic morphologic feature of idiopathic hypertrophic subaortic stenosis.
Role-based access control in Java (1998)

Article Role-based access control in Java Share on Author: Luigi Giuri Fondazione Ugo Bordoni, Roma, Italy Fondazione Ugo Bordoni, Roma, ItalyView Profile Authors Info & Claims RBAC '98: Proceedings of the third ACM workshop on Role-based access controlOctober 1998 Pages 91–100https://doi.org/10.1145/286884.286904Online:01 October 1998Publication History 11citation1,473DownloadsMetricsTotal Citations11Total Downloads1,473Last 12 Months11Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Revealing pyrolysis chemistry for biofuels production: Conversion of cellulose to furans and small oxygenates (2011)

Biomass pyrolysis utilizes high temperatures to produce an economically renewable intermediate (pyrolysis oil) that can be integrated with the existing petroleum infrastructure to produce biofuels. The initial chemical reactions in pyrolysis convert solid biopolymers, such as cellulose (up to 60% of biomass), to a short-lived (less than 0.1 s) liquid phase, which subsequently reacts to produce volatile products. In this work, we develop a novel thin-film pyrolysis technique to overcome typical experimental limitations in biopolymer pyrolysis and identify α-cyclodextrin as an appropriate small-molecule surrogate of cellulose. Ab initio molecular dynamics simulations are performed with this surrogate to reveal the long-debated pathways of cellulose pyrolysis and indicate homolytic cleavage of glycosidic linkages and furan formation directly from cellulose without any small-molecule (e.g., glucose) intermediates. Our strategy combines novel experiments and first-principles simulations to allow detailed chemical mechanisms to be constructed for biomass pyrolysis and enable the optimization of next-generation biorefineries.
Ultra-short-term Photovoltaic Power Prediction Based on VMD-LSTM-RVM Model (2021)

Abstract Aiming at the randomness and obvious fluctuation of photovoltaic power, this paper proposes a method that combines Variational Modal Decomposition (VMD), Long Short-Term Memory (LSTM) network and Relevance Vector Machine (RVM) to achieve ultra-short-term photovoltaic power prediction. Firstly, the VMD decomposition technology is used to decompose the historical photovoltaic power sequence into different modes to reduce the non-stationarity of the data; then an LSTM prediction model is established for each mode, and the modal prediction values are reconstructed to obtain the power prediction value; in order to further improve the prediction accuracy of the model, the error sequence is modeled and predicted by RVM; finally, the prediction power value and the prediction error value are superimposed to obtain the final prediction result. Simulation results show that this method effectively improves the accuracy of photovoltaic power prediction.
Organic molecular beam deposition: fundamentals, growth dynamics, and<i>in situ</i>studies (2008)

We review recent progress on thin film growth by organic molecular beam deposition (OMBD). We give a brief overview of growth physics with emphasis on the specific characteristics of organic materials, such as weak van der Waals binding forces and conformational and orientational degrees of freedom of the molecular building blocks. Two recent developments in experimental studies of OMBD will be discussed in more detail: (1) we will give examples for real-time and in situ growth studies during deposition of the organic semiconductors pentacene, diindenoperylene, and PTCDA and (2) we will give an overview of high precision in situ investigations of the first molecular monolayer, in particular using the x-ray standing wave technique.
Learning generative models for monocular body pose estimation (2007)

Abstract. We consider the problem of monocular 3d body pose tracking from video sequences. This task is inherently ambiguous. We propose to learn a generative model of the relationship of body pose and image appearance using a sparse kernel regressor. Within a particle filtering framework, the potentially multimodal posterior probability distributions can then be inferred. The 2d bounding box location of the person in the image is estimated along with its body pose. Body poses are modelled on a low-dimensional manifold, obtained by LLE dimensionality reduction. In addition to the appearance model, we learn a prior model of likely body poses and a nonlinear dynamical model, making both pose and bounding box estimation more robust. The approach is evaluated on a number of challenging video sequences, showing the ability of the approach to deal with low-resolution images and noise. 1
Polyplex gene delivery modulated by redox potential gradients (2006)

Polyplexes sensitive to redox potential gradients represent a promising class of vectors for delivery of nucleic acids. This review focuses on the recent advances in the development of these vectors. The biological rationale for the design of redox-sensitive polyplexes is discussed together with the basic synthetic approaches for introducing reducible disulfide bonds into the structure of the polyplexes. The biological properties of the redox-sensitive polyplexes of plasmid DNA, mRNA, antisense oligonucleotides and siRNA are reviewed with emphasis on in vitro cellular delivery, cytotoxicity and in vivo activity. Overall, redox-sensitive polyplexes represent a promising platform for further development as vectors for delivery of a wide variety of therapeutic nucleic acids.
Deletion of Fifteen Open Reading Frames from Modified Vaccinia Virus Ankara Fails to Improve Immunogenicity (2015)

Modified vaccinia virus Ankara (MVA) is a highly attenuated strain of vaccinia virus, which has been used as a recombinant vaccine vector in many vaccine development programmes. The loss of many immunosuppressive and host-range genes resulted in a safe and immunogenic vaccine vector. However it still retains some immunomodulatory genes that may reduce MVA immunogenicity. Earlier reports demonstrated that the deletion of the A41L, B15R, C6L, or C12L open reading frames (ORFs) enhanced cellular immune responses in recombinant MVA (rMVA) by up to 2-fold. However, previously, we showed that deletion of the C12L, A44L, A46R, B7R, or B15R ORFs from rMVA, using MVA-BAC recombineering technology, did not enhance rMVA immunogenicity at either peak or memory cellular immune responses. Here, we extend our previous study to examine the effect of deleting clusters of genes on rMVA cellular immunogenicity. Two clusters of fifteen genes were deleted in one rMVA mutant that encodes either the 85A antigen of Mycobacterium tuberculosis or an immunodominant H2-Kd-restricted murine malaria epitope (pb9). The deletion mutants were tested in prime only or prime and boost vaccination regimens. The responses showed no improved peak or memory CD8+ T cell frequencies. Our results suggest that the reported small increases in MVA deletion mutants could not be replicated with different antigens, or epitopes. Therefore, the gene deletion strategy may not be taken as a generic approach for improving the immunogenicity of MVA-based vaccines, and should be carefully assessed for every individual recombinant antigen.
Import of Peroxisomal Matrix and Membrane Proteins (2000)

This review summarizes the progress made in our understanding of peroxisome biogenesis in the last few years, during which the functional roles of many of the 23 peroxins (proteins involved in peroxisomal protein import and peroxisome biogenesis) have become clearer. Previous reviews in the field have focussed on the metabolic functions of peroxisomes, aspects of import/biogenesis the role of peroxins in human disease, and involvement of the endoplasmic reticulum in peroxisome membrane biogenesis as well as the degradation of this organelle. This review refers to some of the earlier work for the sake of introduction and continuity but deals primarily with the more recent progress. The principal areas of progress are the identification of new peroxins, definition of protein-protein interactions among peroxins leading to the recognition of complexes involved in peroxisomal protein import, insight into the biogenesis of peroxisomal membrane proteins, and, of most importance, the elucidation of the role of many conserved peroxins in human disease. Given the rapid progress in the field, this review also highlights some of the unanswered questions that remain to be tackled.
Identification of a blood-based biomarker panel for classification of Alzheimer's disease (2011)

An ideal diagnostic test for Alzheimer's disease (AD) should be non-invasive and easily applicable. Thus, there is a clear need to search for biomarkers in blood. In the present study, we have used multivariate data analysis [support vector machine (SVM)] to investigate whether a blood-based biomarker panel allows discrimination between AD patients and healthy controls at the individual level. We collected a total of 155 serum samples from individuals with early AD and age-matched healthy controls and measured serum levels of 24 markers involved in several biological pathways by ELISA. The dataset was randomly split into a training set for predictor discovery and classification training and a test set for class prediction of blinded samples (3:1 ratio) to evaluate the chosen predictors and parameters. After selection of a feature group of the three most discriminative parameters (cortisol, von Willebrand factor, oxidized LDL antibodies) in the training set, the application of SVM to the training/independent test dataset resulted in an 81.7%/87.1% correct classification for AD and control subjects. In conclusion, we identified a panel of three blood markers, which allowed SVM-based distinguishing of AD patients from healthy controls on a single-subject classification level with clinically relevant accuracy and validity. Blood-based biomarkers might have utility in AD diagnostics as screening tool before further classification with CSF biomarkers and imaging. Future studies should examine whether blood-based biomarkers may also be useful to differentiate AD patients from other dementias.
Functional Characterization of Lymphokines From the EL-4 T Cell Line That Activate Macrophages for Nonspecific Tumor Cytotoxicity (1984)

Culture fluids from a phorbol myristate acetate-stimulated EL-4 thymoma cell line were previously found to activate mouse macrophages to become nonspecifically tumoricidal. By gel filtration, 23,000- and 45,000-MW peaks were identified. In this study we compared EL-4 culture fluid activity with that obtained from antigen-stimulated mouse spleen cells. By four criteria, functional activity from the two sources was comparable: 1) Macrophage activation could be separated temporally into two steps, priming and triggering. 2) Macrophages activated by the fluids exhibited peak cytotoxic activity within 5-9 hr; no cytotoxic activity was demonstrable if addition of target cells was delayed 14 hr. 3) Mouse peritoneal exudate macrophages, but not resident macrophages, became cytotoxic after a 5-hr incubation with culture fluids. 4) Macrophages from certain strains of mice were incapable of activation; the same pattern of strain unresponsiveness was observed with both EL-4 and spleen cell culture fluids. Thus, it is likely that the two EL-4 products and the mouse spleen cell lymphokine activate the same cytotoxic mechanism.
The Embattled Body (2000)

Abstract This chapter examines women's and men's bodily experiences of infertility in the context of cultural dialogues about reproduction and gender. It describes gendered ideals of the body that profoundly affect women's and men's responses to bodily disorder. Bodily order and cultural order are equated with fertility. People living with infertility who subscribe to heterosexual views of gender experience are sensitive to dominant ideologies of gender. They feel different from others because of their infertility. Thus, while gender is destabilized, issues of normalcy persist. Those affected react both by attempting to fit into rigid cultural molds and by resisting those molds. Attempts to achieve a state of “gender normalcy” are characterized by inconsistency. The stories that follow illustrate the interaction of gender, sexuality, and feelings about the ability to reproduce in shaping people's ideas about themselves.
Adaptively Asymmetric Pattern Search for Fast Block-Matching Motion Estimation (2006)

In this paper, we invent a novel fast block-matching algorithm (BMA) for motion estimation (ME), called adaptively asymmetric pattern search (AAPS). Different to the other BMAs, this algorithm uses an asymmetrical search pattern and a predicted vector at the first search step, and dynamically adjusts the size of search pattern to minimize the number of search points. We have already applied AAPS to the process of motion estimation in the MPEG-4 encoding platform, and compared this algorithm with the other BMAs. The experimental result shows that AAPS achieves a 56-65% and 20% improvement in search speed respectively compared to the diamond search algorithm and the adaptive rood pattern search algorithm, and simultaneously maintains a high PSNR.