gebhart/patrepeval huggingface dataset:
<title>Influence Of Alignment Errors Of A Telescope System On Its Aberration Field</title> (1980)

It is shown that, for each field-dependent aberration type, the effect of tilts and decentrations is to produce a more complicated field dependence and local orientation of the aberration without otherwise changing its character. Particular attention is given to astigmatism.
Biochemical characterization of USP7 reveals post‐translational modification sites and structural requirements for substrate processing and subcellular localization (2007)

Ubiquitin specific protease 7 (USP7) belongs to the family of deubiquitinating enzymes. Among other functions, USP7 is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a 130-kDa protein with a cysteine peptidase core, N- and C-terminal domains required for protein-protein interactions. In the present study, recombinant USP7 full length, along with several variants corresponding to domain deletions, were expressed in different hosts in order to analyze post-translational modifications, oligomerization state, enzymatic properties and subcellular localization patterns of the enzyme. USP7 is phosphorylated at S18 and S963, and ubiquitinated at K869 in mammalian cells. In in vitro activity assays, N- and C-terminal truncations affected the catalytic efficiency of the enzyme different. Both the protease core alone and in combination with the N-terminal domain are over 100-fold less active than the full length enzyme, whereas a construct including the C-terminal region displays a rather small decrease in catalytic efficiency. Limited proteolysis experiments revealed that USP7 variants containing the C-terminal domain interact more tightly with ubiquitin. Besides playing an important role in substrate recognition and processing, this region might be involved in enzyme dimerization. USP7 constructs lacking the N-terminal domain failed to localize in the cell nucleus, but no nuclear localization signal could be mapped within the enzyme's first 70 amino acids. Instead, the tumor necrosis factor receptor associated factor-like region (amino acids 70-205) was sufficient to achieve the nuclear localization of the enzyme, suggesting that interaction partners might be required for USP7 nuclear import.
Hepatoma-derived Growth Factor Predicts Disease Severity and Survival in Pulmonary Arterial Hypertension (2016)

Elevated HDGF was associated with worse functional class, exertional intolerance, and increased mortality in PAH, suggesting HDGF as a potential biomarker for predicting mortality and as having possible diagnostic value for distinguishing PAH from non-PAH. HDGF may add additional value in PAH risk stratification in clinical trials and may represent a potential target for future PAH drug development.
Possible DNA-RNA tumor virus interaction in human lymphomas: expression of retroviral proteins in Ramos lymphoma lines is enhanced after conversion with Epstein-Barr virus. (1984)

Epstein-Barr virus (EBV)-genome-negative human lymphoma lines, Ramos and BJAB, can be converted by EBV in vitro into EBV-genome-positive virus nonproducer lines. These cell lines have been used to identify surface antigens unique to EBV, with the expectation that such determinants might be related to the antigenic target responsible for EBV-specific immunosurveillance. Antisera prepared in rabbits immunized with either whole cells or purified plasma membranes were used in immunoblot experiments to analyze antigenic differences resulting from expression of the resident EBV genome. Unexpectedly, an increase in polypeptides of 32 and 70 kilodaltons was consistently observed in the EBV-converted Ramos lines. In contrast, these antigens were not expressed in BJAB or in its EBV-converted lines. These data suggested that p32 and gp70 might be murine leukemia virus (MuLV)-coded antigens because Ramos, but not BJAB, had been passaged in athymic nude mice during establishment of this cell line. This conclusion was confirmed by using antisera specific for MuLV p30 and gp70. Retroviral antigens were expressed constitutively at low levels in Ramos. Quantitative immunoblotting showed that EBV conversion of Ramos amplified the expression of MuLV proteins 3- to 5-fold. The molecular mechanism responsible for the enhanced expression is unknown. The biological relevance of this phenomenon is also not clear, but the interaction between a DNA and a RNA tumor virus in a Burkitt lymphoma line that carries both viruses may have important biological consequences in relation to retrovirus latency and tumor induction. These results also show that caution must be used when ascribing "uniqueness" to EBV-determined antigens, particularly in the Ramos lines. This warning extends also to the use of Ramos cell lines as immunogens, because immunization of rabbits elicited antibodies that recognized proteins of the same size as the retroviral antigens.
Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells (2020)

We propose that metabolic changes and associated mitochondrial overactivation are early adaptations to glucose stress, and may reflect what happens as a result of poor blood glucose control. Inhibition of mitochondrial pyruvate transport reduces mitochondrial nutrient overload and allows beta cells to recover from chronic glucose stress. Graphical abstract.
qNVRAM: quasi non-volatile RAM for low overhead persistency enforcement in smartphones (2014)

The persistent storage options in smartphones employ journaling or double-write to enforce atomicity, consistency and durability, which introduces significant overhead to system performance. Our in-depth examination of the issue leads us to believe that much of the overhead would be unnecessary if we rethink the volatility of memory considering the battery-backed characteristics of DRAM in modern-day smartphones. With this rethinking, we propose quasi Non-Volatile Memory (qNVRAM), a new design that makes the DRAM in smartphones quasi non-volatile, to help remove the performance overhead of enforcing persistency. We assess the feasibility and effectiveness of our design by implementing a persistent page cache in SQLite. Our evaluation on a real Android smartphone shows that qNVRAM speeds up the insert, update and delete transactions by up to 16.33×, 15.86× and 15.76× respectively.
Graphene Oxide−MnO<sub>2</sub> Nanocomposites for Supercapacitors (2010)

A composite of graphene oxide supported by needle-like MnO(2) nanocrystals (GO-MnO(2) nanocomposites) has been fabricated through a simple soft chemical route in a water-isopropyl alcohol system. The formation mechanism of these intriguing nanocomposites investigated by transmission electron microscopy and Raman and ultraviolet-visible absorption spectroscopy is proposed as intercalation and adsorption of manganese ions onto the GO sheets, followed by the nucleation and growth of the crystal species in a double solvent system via dissolution-crystallization and oriented attachment mechanisms, which in turn results in the exfoliation of GO sheets. Interestingly, it was found that the electrochemical performance of as-prepared nanocomposites could be enhanced by the chemical interaction between GO and MnO(2). This method provides a facile and straightforward approach to deposit MnO(2) nanoparticles onto the graphene oxide sheets (single layer of graphite oxide) and may be readily extended to the preparation of other classes of hybrids based on GO sheets for technological applications.
Electronic structure based on the local atomic environment for tight-binding bands (1972)

Some new methods are presented for calculating the density of states n(E) and other aspects of electronic structure in a tight-binding band, without use of Bloch's theorem or the band structure E(k). The methods are therefore applicable to calculating the local density of states at surfaces, impurities etc. and relate the electronic structure to the local atomic environment. They depend on developing the Green function as an infinite continued fraction. There is no difficulty in obtaining n(E) in a few minutes computing time correct to the first 50 moments for an s-band and 10 moments for d-bands. The present paper discusses the methods and ideas, with specific applications to follow.
Electrostatic Probe Data from Bell Sphere BO9 (1973)

Bell Sphere B09 was a 140-lb, 15-in.-diam beryllium sphere which was launched on a suborbital trajectory and re-entered the Earth's atmosphere with a velocity of approximately 6 km/sec. The probe geometries and locations were: a flush disk and a thin wire normal to the surface, each 6° off the front stagnation point, a flush disk 100° off the stagnation point, and a thin wire on a 2-in. support in the base recirculation region. The altitude ranges for which data were obtained are shown in Table 1. The motion of the sphere during re-entry was complicated and the probe currents were therefore strongly modulated and depended not only upon the ionization level, but also upon the instantaneous location of the probes in the flowfield. The sphere motion has been resolved and both data and results are presented a) at a fixed angle off the stagnation point as a function of altitude, and b) at a fixed altitude as a function of angle off the stagnation point. Only the results of the former will be presented in this synoptic. Other results obtained are the electron-to-ion current ratios and plasma potential measurements.
Electrical Propagation in Synthetic Ventricular Myocyte Strands From Germline Connexin43 Knockout Mice (2004)

To characterize the role of connexin43 (Cx43) as a determinant of cardiac propagation, we synthesized strands and pairs of ventricular myocytes from germline Cx43-/- mice. The amount of Cx43, Cx45, and Cx40 in gap junctions was analyzed by immunohistochemistry and confocal microscopy. Intercellular electrical conductance, gj, was measured by the dual-voltage clamp technique (DVC), and electrical propagation was assessed by multisite optical mapping of transmembrane potential using a voltage-sensitive dye. Compared with wild-type (Cx43+/+) strands, immunoreactive signal for Cx43 was reduced by 46% in Cx43+/- strands and was absent in Cx43-/- strands. Cx45 signal was reduced by 46% in Cx43+/- strands and to the limit of detection in Cx43-/- strands, but total Cx45 protein levels measured in immunoblots of whole cell homogenates were equivalent in all genotypes. Cx40 was detected in 2% of myocytes. Intercellular conductance, gj, was reduced by 32% in Cx43+/- cell pairs and by 96% in Cx43-/- cell pairs. The symmetrical dependence of gj on transjunctional voltage and properties of single-channel recordings indicated that Cx45 was the only remaining connexin in Cx43-/- cells. Propagation in Cx43-/- strands was very slow (2.1 cm/s versus 52 cm/s in Cx43+/+) and highly discontinuous, with simultaneous excitation within and long conduction delays (2 to 3 ms) between individual cells. Propagation was abolished by 1 mmol/L heptanol, indicating residual junctional coupling. In summary, knockout of Cx43 in ventricular myocytes leads to very slow conduction dependent on the presence of Cx45. Electrical field effect transmission does not contribute to propagation in synthetic strands.
ChemInform Abstract: Sulfur‐Substituted Phosphatidylethanolamines. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Colorimetric Determination of Chloride with Mercuric Chloranilate (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTColorimetric Determination of Chloride with Mercuric ChloranilateJ. E. Barney and R. J. BertolaciniCite this: Anal. Chem. 1957, 29, 8, 1187–1188Publication Date (Print):August 1, 1957Publication History Published online1 May 2002Published inissue 1 August 1957https://doi.org/10.1021/ac60128a023RIGHTS & PERMISSIONSArticle Views328Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (269 KB) Get e-Alerts Get e-Alerts
From micro- to nanostructured implantable device for local anesthetic delivery (2016)

Local anesthetics block the transmission of painful stimuli to the brain by acting on ion channels of nociceptor fibers, and find application in the management of acute and chronic pain. Despite the key role they play in modern medicine, their cardio and neurotoxicity (together with their short half-life) stress the need for developing implantable devices for tailored local drug release, with the aim of counterbalancing their side effects and prolonging their pharmacological activity. This review discusses the evolution of the physical forms of local anesthetic delivery systems during the past decades. Depending on the use of different biocompatible materials (degradable polyesters, thermosensitive hydrogels, and liposomes and hydrogels from natural polymers) and manufacturing processes, these systems can be classified as films or micro- or nanostructured devices. We analyze and summarize the production techniques according to this classification, focusing on their relative advantages and disadvantages. The most relevant trend reported in this work highlights the effort of moving from microstructured to nanostructured systems, with the aim of reaching a scale comparable to the biological environment. Improved intracellular penetration compared to microstructured systems, indeed, provides specific drug absorption into the targeted tissue and can lead to an enhancement of its bioavailability and retention time. Nanostructured systems are realized by the modification of existing manufacturing processes (interfacial deposition and nanoprecipitation for degradable polyester particles and high- or low-temperature homogenization for liposomes) or development of novel strategies (electrospun matrices and nanogels). The high surface-to-volume ratio that characterizes nanostructured devices often leads to a burst drug release. This drawback needs to be addressed to fully exploit the advantage of the interaction between the target tissues and the drug: possible strategies could involve specific binding between the drug and the material chosen for the device, and a multiscale approach to reach a tailored, prolonged drug release.
Colloidal Nanocrystals of Zeolite β Stabilized in Alumina Matrix (1999)

Characteristics of zeolite β in stable aqueous colloidal solution were measured by cryo-TEM, DLS, SAXS and after separation from solution by SEM, HR-TEM. Twenty-nanometer spherical zeolite crystals were measured in equilibrium with flocculates. Mixing of colloidal zeolite solution with aluminogel yielded coagulation of both materials. The mass of zeolite adsorbed by aluminogel increased with decreasing pH. After calcination, pellets of the composite material at zeolite loading below 60 wt % contained separated nanocrystals of 10−15-nm zeolite β stabilized in the mesopores of alumina matrix. The imbedded zeolite had high structure order and acidity. No blocking of the zeolite micropores in composite materials was detected. The activity of zeolite β nanocrystals (imbedded in alumina matrix) in cumene cracking twice that of bulk nanozeolite clusters.
LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson’s disease model (2016)

The original properties of tissue-specific stem cells, regardless of their tissue origins, are inevitably altered during in vitro culturing, lessening the clinical and research utility of stem cell cultures. Specifically, neural stem cells derived from the ventral midbrain lose their dopamine neurogenic potential, ventral midbrain-specific phenotypes, and repair capacity during in vitro cell expansion, all of which are critical concerns in using the cultured neural stem cells in therapeutic approaches for Parkinson's disease. In this study, we observed that the culture-dependent changes of neural stem cells derived from the ventral midbrain coincided with loss of RNA-binding protein LIN28A expression. When LIN28A expression was forced and sustained during neural stem cell expansion using an inducible expression-vector system, loss of dopamine neurogenic potential and midbrain phenotypes after long-term culturing was blocked. Furthermore, dopamine neurons that differentiated from neural stem cells exhibited remarkable survival and resistance against toxic insults. The observed effects were not due to a direct action of LIN28A on the differentiated dopamine neurons, but rather its action on precursor neural stem cells as exogene expression was switched off in the differentiating/differentiated cultures. Remarkable and reproducible behavioural recovery was shown in all Parkinson's disease rats grafted with neural stem cells expanded with LIN28A expression, along with extensive engraftment of dopamine neurons expressing mature neuronal and midbrain-specific markers. These findings suggest that LIN28A expression during stem cell expansion could be used to prepare therapeutically competent donor cells.
TOWARD BETTER, COLORFUL DEVICES (2004)

TWO NEW REPORTS IN THE hot field of organic electronics highlight advances in the fabrication of flexible transistors and colorful displays. A group led byjohn A. Rogers, a materials science professor at the University of Illinois, Urbana- Champaign, and Michael E. Gershenson, a physics professor at Rutgers University, has made single-crystal organic transistors using an unusual fabrication method that may allow them to gain a deeper understanding into the basic operation of these devices [ Science , 303, 1644(2004)}. Organic transistors usually are built by depositing components such as electrodes and dielectrics onto an organic material. The fabrication process, though, often damages the organic material's fragile surface. The team, which also includes scientists from Lucent Technologies' Bell Laboratories, circumvents this difficulty by placing the components on a silicone rubber support and then covering the support with the organic material—a highquality rubrene crystal This lamination process can ...
Dye-doped cholesteric-liquid-crystal room-temperature single-photon source (2004)

Abstract Fluorescence antibunching from single terrylene molecules embedded in a cholesteric-liquid-crystal host is used to demonstrate operation of a room-temperature single-photon source. One-dimensional (1-D) photonic-band-gap microcavities in planar-aligned cholesteric liquid crystals with band gaps from visible to near-infrared spectral regions are fabricated. Liquid-crystal hosts (including liquid crystal oligomers and polymers) increase the source efficiency, firstly, by aligning the dye molecules along the direction preferable for maximum excitation efficiency (deterministic molecular alignment provides deterministically polarized output photons), secondly, by tuning the 1-D photonic-band-gap microcavity to the dye fluorescence band and thirdly, by protecting the dye molecules from quenchers, such as oxygen. In our present experiments, using oxygen-depleted liquid-crystal hosts, dye bleaching is avoided for periods exceeding one hour of continuous 532 nm excitation.
Retrovirus-Mediated Gene Transfer into Salivary Glands <i>In Vivo</i> (1996)

In the present report, we show prolonged expression of beta-galactosidase (beta-Gal) in the acinar cells of the submandibular and sublingual glands of rats following retrograde ductal injection of the retroviral vector BAG. To facilitate integration of viral DNA, cell division in the gland was induced by the administration of the beta-adrenergic agonist isoproterenol prior to the delivery of the vector. The frequency of cells stained for beta-Gal was higher if the virus was injected 4-20 hr after the two injections of isoproterenol given 24 hr apart than after the injection of only one dose of the drug. Without stimulation of cell division, no integration of the viral DNA was observed. Expression of the marker enzyme was observed up to 43 days, the limit of the observation period. The data indicate that salivary glands are potential targets of retrovirus-mediated gene transfer for somatic gene therapy.
Stable silicon heterocyclic derivatives of branched alkane-diols (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStable silicon heterocyclic derivatives of branched alkane-diolsCecil L. FryeCite this: J. Org. Chem. 1969, 34, 9, 2496–2499Publication Date (Print):September 1, 1969Publication History Published online1 May 2002Published inissue 1 September 1969https://pubs.acs.org/doi/10.1021/jo01261a002https://doi.org/10.1021/jo01261a002research-articleACS PublicationsRequest reuse permissionsArticle Views204Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Occurrence of an Inducible Glutaminase in <i>Bacillus licheniformis</i> (1981)

We report the presence of l -glutamine aminohydrolase activity (EC 3.5.1.2) in extracts of B. licheniformis A5. The activity was induced by glutamine and repressed by glucose.
Development of BBD Adding-Delay Architecture for Ultrasonic Micro Array Sensor (2005)

Bucket Brigade Device (BBD) adding-delay architecture was proposed as the analog beamformer for piezoelectric micromachined ultrasonic sensor phased array. BBD adding-delay architecture were used both as delay and adding elements, and the input signals were distributed adding in the process of delay. This architecture was useful to reduce chip area, simplify system design, and realize on-chip integration. Combining piezoelectric micromachined ultrasonic array sensors and the analog delay-sum circuits successfully performed two-dimensional object detection.
Switch from intravenous to subcutaneous immunoglobulin in CIDP and MMN: improved tolerability and patient satisfaction (2014)

In seven of the eight patients, SCIG gave improved tolerability and patient satisfaction with similar efficacy compared with IVIG.