gebhart/patrepeval huggingface dataset:
Increased function and survival of IL-15-transduced human dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2. (2002)

It has been recently demonstrated that dendritic cells (DC) coincubated with interleukin (IL)-15 express high levels of the Bcl-2 family of proteins and display an increased resistance to tumor-induced apoptotic death. Here, the phenotype, functions, and survival of human DC transduced with adenoviral vector encoding the human IL-15 gene were studied. The transduction of DC with the IL-15 gene resulted in a significant elevation of expression of CD83, CD86, and CD40 molecules, which was blocked by anti-IL-15 monoclonal antibodies. This effect was also accompanied by an increased production of IL-12 and stimulated ability of DC to induce T cell proliferation. Furthermore, transduction of DC with the IL-15 gene significantly increased their resistance to prostate cancer-induced apoptosis: Overexpression of IL-15 on DC blocked tumor-induced inhibition of Bcl-2 expression and prolonged DC survival after coincubation with tumor cells. Finally, overexpression of IL-15 in DC was associated with a higher level of expression of IL-15 receptor alpha chain mRNA. In summary, these results suggest that transduction of DC with the IL-15 gene markedly stimulates DC function and protects them from tumor-induced apoptosis.
Polyion complex fiber and capsule formed by self‐assembly of poly‐L‐Lysine and gellan at solution interfaces (2001)

Different characteristic surface structures such as capsules, regularly spaced droplets, and fibers are formed by electrostatic interaction between poly-L-lysine (PLL) and gellan gum via polyion complex (PIC) formation. Spherical droplet PIC capsules of varying diameters form in solutions. Some dyes adsorb on the surface of the capsules, and other dyes penetrate into the capsules. The strong PIC fiber can be spinnable by gravity and by wet spinning in ethanol. This fiber possesses a counterion pairing structure and exhibits the nervation/veining pattern and hollow yarn. The tensile strength of the fiber is 27.8 kg/mm2 [1.40 g/denier (d)] and the knotting strength is 9.98 kg/mm2 (1.13 g/d). By using an organic crosslinking agent, epichlorohydrin, the tensile strength can be increased to 38.5 kg/mm2 (2.46 g/d) and the knotting strength can be increased to 12.2 kg/mm2 (1.99 g/d). The PIC fiber can be dyed by five different dyeing procedures such as direct and vat dyeings. The PLL PIC fiber is water insoluble and has potential as a new synthetic polypeptide fiber technology. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 79: 437–446, 2001
Multileaf collimation of electrons—clinical effects on electron energy modulation and mixed beam therapy depending on treatment head design (2002)

The aim of this study was to explore the possibilities of using multileaf-collimated electron beams for advanced radiation therapy with conventional scattering foil flattened beams. Monte Carlo simulations were performed with the aim to improve electron beam characteristics and enable isocentric multileaf collimation. The scattering foil positions, monitor chamber thickness, the MLC location and the amount of He in the treatment head were optimized for three common commercial accelerators. The performance of the three optimized treatment head designs was compared for different SSDs in air, at treatment depth in water and for some clinical cases. The effects of electron/photon beam matching including generalized random and static errors using Gaussian one-dimensional (1 D) error distributions, and also electron energy modulation, were studied at treatment depth in water. The modification of the treatment heads improved the electron beam characteristics and enabled the use of multileaf collimation in isocentric delivery of both electron and photon beams in a mixed beam IMRT procedure.
zfh-1, the <i>Drosophila</i> Homologue of ZEB, Is a Transcriptional Repressor That Regulates Somatic Myogenesis (1999)

zfh-1 is a member of the zfh family of proteins, which all contain zinc finger and homeodomains. The roles and mechanisms of action of most family members are still unclear. However, we have shown previously that another member of the family, the vertebrate ZEB protein, is a transcriptional repressor that binds E box sequences and inhibits myotube formation in cell culture assays. zfh-1 is downregulated in Drosophila embryos prior to myogenesis. Embryos with zfh-1 loss-of-function mutation show alterations in the number and position of embryonic somatic muscles, suggesting that zfh-1 could have a regulatory role in myogenesis. However, nothing is known about the nature or mechanism of action of zfh-1. Here, we demonstrate that zfh-1 is a transcription factor that binds E box sequences and acts as an active transcriptional repressor. When zfh-1 expression was maintained in the embryo beyond its normal temporal pattern of downregulation, the differentiation of somatic but not visceral muscle was blocked. One potential target of zfh-1 in somatic myogenesis could be the myogenic factor mef2. mef2 is known to be regulated by the transcription factor twist, and we show here that zfh-1 binds to sites in the mef2 upstream regulatory region and inhibits twist transcriptional activation. Even though there is little sequence similarity in the repressor domains of ZEB and zfh-1, we present evidence that zfh-1 is the functional homologue of ZEB and that the role of these proteins in myogenesis is conserved from Drosophila to mammals.
Differential effects of microinjections of d-amphetamine into the nucleus accumbens or the caudate putamen on the rat's ability to ignore an irrelevant stimulus. (1982)

Latent inhibition is an attentional process by which animals learn to ignore an irrelevant stimulus. Rats received either 0 or 30 preexposures to a tone which was later used as a conditioned stimulus (CS) in a two-way avoidance task. Tone preexposure resulted in retarded conditioning (i.e., latent inhibition) in animals which received microinjections of saline or amphetamine in the caudate-putamen and for those which received microinjections of saline in the nucleus accumbens. This latent inhibition effect, however, was not present in animals which received d-amphetamine microinjections in the nucleus accumbens. The failure of CS preexposure to retard conditioning in these animals was not due to drug-induced changes in either tone or shock sensitivity. The results are discussed in terms of the role of the mesolimbic dopamine system in learning to ignore an irrelevant stimulus and the use of LI as a possible animal model of the attentional deficit that seems to characterize some subpopulations of schizophrenic humans.
Petrophysical Joint Inversion of Multi-Geophysical Attributes and Measurements for Reservoir Characterization (2017)

Abstract Interpretation of petrophysical parameters such as porosity and saturation is very important for reservoir characterization and resources evaluation. Petrophysical inversion is typically done using well log data to characterize the reservoirs. Seismic and electromagnetic (EM) measurements are sensitive to different rock properties and their joint interpretation can improve the characterization results. We address the task of improving the interpretation of porosity and fluid saturation in the reservoir rocks by means of the joint inversion of seismic, gravity and EM data subject to geological constraints. Simultaneous inversion is expected to provide higher sensitivity, better resolution, and an overall more robust estimation of rock parameters than conventional log analysis. We developed in-house petrophysical joint inversion (PJI) codes and tested them on simulated and field data. We also designed a rigorous workflow for reservoir characterization through PJI of multi-geophysical attributes and measurements. First, we conduct analysis and inversion of the available well log data to understand the petrophysics of the reservoir and to choose the constitutive equations linking petrophysical attributes to geophysical ones (calibration). Second, we implement sequential PJI of geophysical attribute volumes such as seismic velocity, density and resistivity. Finally, we produce a full PJI of geophysical measurements such as seismic, gravity and EM data. Each of these steps requires the integration of geophysical, geological and petrophysical knowledge about the specific reservoir. The first step of the workflow was applied to well log data from an important reservoir in Saudi Arabia. Mineralogical information from the well logs indicated mainly calcite with some dolomite at the reservoir depth. The rock properties were adjusted with depth according to the known stratigraphy. The recalculated log resistivity, density and sonic data via joint inversion fit the observed data well. The estimated porosity and fluid saturations were the petrophysical parameters in the joint inversion while gas saturation was ignored. The joint inversion estimated porosity was similar to neutron log-derived porosity. Improved oil saturation estimates are expected to enhance the interpretation of the resource. To test the other two steps of the workflow, we created a simulated 3D multi-geophysical model by lateral interpolation and rescaling of well log data from available wells. Then, we generated the related geophysical data through forward modeling. Finally, we tested the sequential and full PJI algorithms on this dataset. We are currently working on the application of the described method and workflow to a measured dataset from a Saudi Arabian reservoir. If successful, this approach could lead to an overall more robust estimation of the reserves.
Modeling and control of managed pressure drilling operations (2017)

The upstream oil and gas industry has witnessed a marked increase in the number of wells drilled in areas with elevated subsurface formation pressures and narrow drilling margins. Managed Pressure Drilling (MPD) techniques have been developed to deal with the challenge of narrow margin wells, offering great promise for improved rig safety and reduced non-productive time. Automation of MPD operations can ensure improved control over wellbore pressure profiles, and there are several commercial solutions currently available. However, these automation efforts seldom take into account the uncertainty and complex dynamics inherent in subsurface environments, and usually assume ideally functioning sensors and actuators, which is rarely the case in real-world drilling operations. This dissertation describes a set of tools and methods that can form the basis for an automation framework for MPD systems, with specific focus on the surface back-pressure technique of MPD. Model-based control algorithms with robust reference tracking, as well as methods for detecting system faults and handling modeling uncertainty, are integrated with a novel multi-phase hydraulics model. The control system and event detection modules are designed using physics-based representations of the drilling processes, as well as models relating uncertain variables in a probabilistic fashion. Validation on high-fidelity simulation models is conducted in order to ascertain the effectiveness of the developed methods.
Tin Doping of Silicon for Controlling Oxygen Precipitation and Radiation Hardness (2001)

This paper reviews the impact of doping silicon with substitutional tin impurities on the formation of intrinsic and extrinsic lattice defects. The two major topics covered are (i) the effect on the diffusivity and aggregation/precipitation of interstitial oxygen in Czochralski (CZ) silicon and (ii) the formation of stable radiation defects in irradiated Sn-doped material. As demonstrated, the compressive stress associated with incorporating a large Sn atom on a lattice site is the basic feature governing the interactions with point defects. Consequently, Sn acts as a selective vacancy trap, while, in contrast, not affecting interstitial reactions. This leads to a reduced formation of oxygen thermal donors in n-type Si and lowers the concentration of vacancy-oxygen and divacancy centers in irradiated material. Enhanced oxygen precipitation has been noted around 750 degreesC in p-type CZ silicon. Furthermore, specific Sn-related radiation defects are introduced, which question the use of doping with tin as a technique for substrate hardening. (C) 2001 The Electrochemical Society.
WEKA Manual for Version 3-6-10 (2008)

This manual is licensed under the GNU General Public License version 2. More information about this license can be found at
Selective Photoinduced Ligand Exchange in a New Tris–Heteroleptic Ru(II) Complex (2013)

The complex cis-[Ru(biq)(phen)(CH3CN)2](2+) (1, biq = 2,2'-biquinoline, phen = 1,10-phenathroline) displays selective photosubstitution of only one CH3CN ligand with a solvent molecule upon irradiation with low energy light (λ(irr) ≥ 550 nm), whereas both ligands exchange with λ(irr) ≥ 420 nm. In contrast, [Ru(phen)2(CH3CN)2](2+) (2) and [Ru(biq)2(CH3CN)2](2+) (3) exchange both CH3CN ligands with similar rates upon irradiation with a broad range of wavelengths. The photolysis of 1 in the presence of pyridine (py) results in the formation of the intermediate cis-[Ru(biq)(phen)(py)(MeCN)](2+), which was isolated and characterized by X-ray crystallography, revealing that the CH3CN positioned trans to the phen ligand is more photolabile than that positioned trans to the biq ligand when irradiated with low energy light. These results are explained using the calculated stabilities of the two possible products, together with the molecular orbitals involved in the lowest energy excited state.
Electrochemical Properties of Lithium Ion Conducting Solid Polymer Electrolytes (1994)

In 1985 our laboratory initiated an investigation of the electrochemical reactions of molecular electron donor/acceptor species dissolved in solid and semi-solid solvents. Poly-ether polymer electrolytes were selected as the model solid and semi-solid solvents, and the redox species have included ferrocenes, metal bipyridine complexes, tetracyanoquinodimethane (TCNQ), and derivatives in which poly-ether chains have been attached to such species. The thrust of this investigation was firstly, to develop methodology for obtaining quantitatively interpretable electron transfer and mass transport rates of such molecular solutes in solid or semi-solid solvents, and secondly, to explore ways in which their solid state behavior differs form that familiar in fluid electrolyte solutions. This paper will draw together the essential aspects of the microelectrode-based solid state voltammetry methodology developed, and describe some of the special aspects of electron transfer and mass transport dynamics observed during this still ongoing investigation.
Static Rock Splitter Using Shape Memory Alloy as Pressure Source. (1991)

A new kind of static rock splitter has been developed taking advantage of TiNi shape memory alloy which attains a maximum recovery force of about 600MPa. The splitter consists of compressively prestrained TiNi rods and a pair of two-layered wedge type platens of steel, and requires no accessory equipments other than heating apparatus. To examine the performance of the splitter, theoretical analysis for the crack initiation and laboratory test using rocklike materials have been performed. It is confirmed that the splitter is not lacking in terms of performance. The breaking time is extremely shorter than those of conventional breaking processes.
Modeling and control of multi-contact centers of pressure and internal forces in humanoid robots (2009)

This paper presents a methodology for the modeling and control of internal forces and moments produced during multi-contact interactions between humanoid robots and the environment. The approach is based on the virtual linkage model which provides a physical representation of the internal forces and moments acting between the various contacts. The forces acting at the contacts are decomposed into internal and resulting forces and the latter are represented at the robot's center of mass. A grasp/contact matrix describing the complex interactions between contact forces and center of mass behavior is developed. Based on this model, a new torque-based approach for the control of internal forces is suggested and illustrated on the Asimo humanoid robot. The new controller is integrated into the framework for whole-body prioritized multitasking enabling the unified control of operational tasks, postures, and internal forces.
Editorial Commentary: Axillary Arteries (2005)

These 3 reports on the axillary artery are grouped together for publication. The first, from Turkey, addresses itself to the unusual or rare occurrence of aneurysms that are caused mostly by trauma. The technical problem for the surgeon lies in the proximity of the lesion to the cords of the brachial plexus. The authors were successful in avoiding neural injury in 3 of the 4 patients. The 4th patient already had neurologic impairment before surgery, which did not resolve after operation. Restoration of circulatory continuity was achieved with either synthetic or saphenous vein grafts, and the authors favor the vein for long-term patency.
IMPLICATIONS OF MODULAR CONTAINERS ON GROCERY DISTRIBUTION COSTS: TRANSPORTATION PERSPECTIVE (1984)

Agribusiness
Order Picking Supported by Mobile Computing (2012)

In this dissertation I present the results of a newly developed mobile computing solution with reasonable investment costs that supports the picking process in a high density picking environment with multiple orders. The developed solution is presented on a head-mounted display (HMD). It has a graphical user interface that displays graphical representations of the shelves to pick from. Results show that in a high density picking environment, this solution is faster than paper-pick lists and pick-by-voice and virtually eliminates errors. Using color helps to identify the correct row and some evidence suggests that symbols and partial images as well as context feedback can further improve the error rate. Testing on an assembly line of an automobile manufacturer where normally pick-by-light was used showed some difficulty in user acceptance for HMDs. A tablet-PC mounted on the pick cart was well accepted in this study and may provide similar benefits and performance.
Molecular Imaging Insights Into Early Inflammatory Stages of Arterial and Aortic Valve Calcification (2011)

Traditional imaging modalities such as computed tomography, although perfectly adept at identifying and quantifying advanced calcification, cannot detect the early stages of this disorder and offer limited insight into the mechanisms of mineral dysregulation. This review presents optical molecular imaging as a promising tool that simultaneously detects pathobiological processes associated with inflammation and early stages of calcification in vivo at the (sub)cellular levels. Research into treatment of cardiovascular calcification is lacking, as shown by clinical trials that have failed to demonstrate the reduction of calcific aortic stenosis. Hence, the need to elucidate the pathways that contribute to cardiovascular calcification and to develop new therapeutic strategies to prevent or reverse calcification has driven investigations into the use of molecular imaging. This review discusses studies that have used molecular imaging methods to advance knowledge of cardiovascular calcification, focusing in particular on the inflammation-dependent mechanisms of arterial and aortic valve calcification.
Translucency of Dental Porcelains (1980)

The translucency of comparable shades of five dental porcelains was determined. Both direct transmittance and total transmittance were measured at wavelengths of 400-700 nm. For 1 mm of porcelain, the values for direct transmittance were low and averaged 0.13 percent, whereas the values for total transmittance averaged 26.8 percent. Transmittance increased with increasing incident wavelength. These results indicated a high degree of light scattering.
A theoretical analysis of acute ischemia and infarction using ECG reconstruction on a 2-D model of myocardium (2001)

We developed a two-dimensional ventricular tissue model in order to probe the determinants of electrocardiographic (ECG) morphology during acute and chronic ischemia. Hyperkalemia was simulated by step changes in [K+]out, while acidosis was induced by reducing Na+ and Ca2+ conductances. Hypoxia was introduced by its effect on potassium activity. During the initial moments of ischemia, ECG changes were characterized by increases in QRS amplitude and ST segment shortening, followed in the advanced phase by ST baseline elevation, T conformation changes, widening of the QRS and significant decreases in QRS amplitude in spite of an enlarged Q. During each phase, potential proarrhythmic mechanisms were investigated. The presence of unexcitable regions of simulated myocardial infarction led to polymorphic ECG. We also observed a nonuniform deflection of the ST segment from beat to beat. We used similar protocols to explore the responses of infarcted myocardium after impairment resolving. We found that despite irreversible uncoupling of the necrotic region, the restored normal ionic concentrations produced an isopotential ST segment and monomorphic ECG complexes, while an enlarged Q wave was still visible. In summary, these numerical experiments indicate the possibility to track in the ECG pathologic changes following the altered electrophysiology of the ischemic heart.
The ID-based non-interactive group communication key sharing scheme using smart cards (2002)

Attention to CSCW has been increasing, resulting in greater needs for secure group communication. In order to realize secure group communication, data which is sent from a member to other members of a group should be encrypted by the cryptographic communication key of the group. We propose an identity-based non-interactive group communication key sharing scheme using smart cards based on the modified copy key (MCK) method. We assume that the smart cards contain the key generators and are secure for tampering. Each user has a smart card and a key generator. A user can generate a group communication key non-interactively with his key generator and the IDs of the other group members using his smart card.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Track 2 피지컬 컴퓨팅 교육 : 아두이노 비행선을 활용한 프로그래밍 교육 설계 (2015)

교육용 프로그래밍 언어의 개발 및 보급으로 초등학생들에게 보다 쉽고 재미있는 프로그래밍 학습 환경을 제공할 수 있다. 최근에는 기존의 프로그래밍 학습 환경보다 보다 더 역동적으로 상호작용할 수 있는 아 두이노를 활용한 프로그래밍 교육이 주목을 받고 있다. 아두이노를 활용한 프로그래밍 교육은 일반 프로그래밍 교육에 비해 교구를 익히는데 필요한 시간과 예산 등 현실적인 이유로 효율성 측면에서 저평가 될 수 있다. 그러나 초등학생들의 발달 단계에 따라 구체적 조작활동 중심의 아두이노 프로그래밍 학습 환경을 제공 할 경우, 흥미나 학습 동기가 보다 장기간 지속될 수 있기 때문에 효율성에 대한 재평가가 이루어져야할 것이다. 본 연구에서는 학생들이 아두이노를 활용한 프로그래밍 교육 프로그램을 설계하고 장기적인 교육 효과를 검증하고자 한다.
Kinetics and Mechanism of the Epoxidation of Allylic Alcohols by Hydrogen Peroxide with Methyltrioxorhenium as Catalyst (1999)

The title reaction was carried out in aqueous acetonitrile (5% and 20% water) and in nitromethane. Provided acid was not added, the product was mostly the epoxide, accompanied by small amounts of the triol that results from acid-catalyzed ring opening of the epoxide. With added acid, only the triol was detected. The kinetic study afforded a striking result: only the diperoxorhenium compound was an epoxidation catalyst; the monoperoxo compound CH(3)Re(O)(2)(eta(2)-O(2)) was inactive; no other substrates, including nonallylic alkenes, show that reactivity difference. This, together with the realization of high diastereoselectivity for 2-cyclohexen-1-ol in chloroform, suggests a particular mode of hydrogen bonding: an O atom of one peroxo group engages in oxygen transfer, in a transition state that is stabilized by hydrogen bonding between the allylic OH group and O atom of the other peroxo group. Calculations supported that conclusion.