gebhart/patrepeval huggingface dataset:
<i>OASIS/CREB3L1</i>is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration<i>in vitro</i> (2014)

CREB3L1 has been recently proposed as a novel metastasis suppressor gene in breast cancer. Our current study highlights CREB3L1 expression, regulation, and function in bladder cancer. We demonstrate a significant downregulation of CREB3L1 mRNA expression (n = 64) in primary bladder cancer tissues caused by tumor-specific CREB3L1 promoter hypermethylation (n = 51). Based on pyrosequencing CREB3L1 methylation was shown to be potentially associated with a more aggressive phenotype of bladder cancer. These findings were verified by an independent public data set containing data from 184 bladder tumors. In addition, immunohistochemical evaluation showed that CREB3L1 protein expression is decreased in bladder cancer tissues as well. Interestingly, protein loss is predominately observed in the nuclei of aggressive tumor cells. Based on in vitro models we clearly show that CREB3L1 re-expression mediates suppression of tumor cell migration and colony growth of high grade and invasive bladder cancer cells. The candidate tumor suppressor and TGF-β signaling inhibitor HTRA3 was furthermore identified as putative target gene of CREB3L1 in both invasive J82 bladder cells and primary bladder tumors. Hence, our data provide for the first time evidence that the transcription factor CREB3L1 may have an important role as a putative tumor suppressor in bladder cancer.
Aequorin variants with improved bioluminescence properties (2009)

The photoprotein aequorin has been widely used as a bioluminescent label in immunoassays, for the determination of calcium concentrations in vivo, and as a reporter in cellular imaging. It is composed of apoaequorin (189 amino acid residues), the imidazopyrazine chromophore coelenterazine and molecular oxygen. The emission characteristics of aequorin can be changed by rational design of the protein to introduce mutations in its structure, as well as by substituting different coelenterazine analogues to yield semi-synthetic aequorins. Variants of aequorin were created by mutating residues His16, Met19, Tyr82, Trp86, Trp108, Phe113 and Tyr132. Forty-two aequorin mutants were prepared and combined with 10 different coelenterazine analogues in a search for proteins with different emission wavelengths, altered decay kinetics and improved stability. This spectral tuning strategy resulted in semi-synthetic photoprotein mutants with significantly altered bioluminescent properties.
ESSAI D'UNE APPLICATION DE LA TRANSFORMATION DE KARHUNEN‐LOÈVE AU TRAITEMENT SISMIQUE * (1978)

A bstract Multispectral recordings used for remote sensing are not without analogy with seismic records from CDP field set‐ups. These seismic data may be regarded as “photographs’ of deep regions of the earth taken from various angles. The Karhunen‐Loève (K.L.) transformation is commonly used for multispectral data processing, where it helps emphasize some features of remote sensing information. The same method may be applied to seismic data processing. Signal‐to‐noise ratio is improved on synthetic or field examples when K.L. transformation is applied instead of conventional CDP stacking. Residual statics seem to be diminished by a significant factor.
Gabapentin as Add‐on Therapy for Refractory Partial Epilepsy: Results of Five Placebo‐Controlled Trials (1994)

Gabapentin (GBP, Neurontin), a new antiepileptic drug (AED) with a novel mechanism of action, exhibits low acute toxicity in mice, rats, and monkeys, and is not teratogenic. GBP pharmacokinetics are simple and predictable; GBP is eliminated by urinary excretion, is not protein-bound or metabolized, does not induce or inhibit hepatic enzymes, and does not interact with other AEDs. In five placebo-controlled, double-blind studies of GBP as add-on therapy, 307 patients with refractory partial seizures received placebo and 485 received GBP dosages of 600, 900, 1,200, or 1,800 mg/day for 12 weeks following a 12-week baseline. Seizure frequency, as measured by response ratio and responder rate, was improved for patients receiving GBP compared with placebo; differences were statistically significant in two of the three large, multicenter studies. Adverse events occurred in 76% of GBP-treated patients, compared with 57% of placebo-treated patients. No serious adverse events were consistently attributable to GBP therapy. Changes in clinical laboratory values were not considered clinically important. GBP represents a significant addition to the armamentarium of AEDs available for treatment of patients with epilepsy.
Effect of fissure integrity on lung volume reduction using a polymer sealant* in advanced emphysema (2012)

Registration numbers for trials contributing to datasets in this report: NCT00884962, NCT01051258 and NCT01181466.
Dye-sensitized solar cells using ZnO tetrapods (2008)

One dimensional (1D) ZnO nanostructures are of interest for applications in dye-sensitized solar cells (DSSCs) since they exhibit significantly improved electron transport compared to that in porous films. However, 1D nanostructures also have a significantly lower surface area than the porous films. Thus, the achieved solar cell efficiencies are typically much lower in spite of the improved charge transport. In this work, we investigated DSSCs based on ZnO tetrapods to achieve an increased surface area compared to that of 1D nanostructures. The cell performance as a function of the tetrapod film thickness and the dye used was studied. To further increase the surface area, mixed morphologies (tetrapods with nanoparticles) were also investigated. Under optimal conditions, an AM 1.5 power conversion efficiency of ∼1.2% was achieved.
Oblivious decision trees graphs and top down pruning (1995)

We describe a supervised learning algorithm, EODG, that uses mutual information to build an oblivious decision tree. The tree is then converted to an Oblivious read-Once Decision Graph (OODG) by merging nodes at the same level of the tree. For domains that are appropriate for both decision trees and OODGs, performance is approximately the same as that of C4.5, but the number of nodes in the OODG is much smaller. The merging phase that converts the oblivious decision tree to an OODG provides a new way of dealing with the replication problem and a new pruning mechanism that works top down starting from the root. The pruning mechanism is well suited for finding symmetries and aids in recovering from splits on irrelevant features that may happen during the tree construction. 1 Introduction Decision trees provide a hypothesis space for supervised machine learning algorithms that is well suited for many datasets encountered in the real world (Breiman, Friedman, Olshen &amp; Stone 1984, Quinlan...
Mica glass ceramics for dental restorations (2018)

Ceramics are popular as dental restorative materials for missing teeth due to their esthetics, chemical durability and ease of fabrication. Glass ceramics are commonly used for the fabrication of dental inlays, veneers, dental crowns and bridges. Mica containing glass ceramics (SiO2-Al2O3-MgO-K2O-B2O3-F) are one of the potential materials due to their machinability, bioactivity and resemblance to tooth colour. The review aims to provide an overview of dental ceramics with emphasis on mica glass ceramics, and their strengthening mechanisms with nucleating agents. The review discusses the clinically relevant properties of various mica based glass ceramic compositions such as fracture toughness, hardness, bending strength, machinability, wear, translucency and provides recommendations for their biocompatibility testing.
Effects of the Principal Nutrients on Lovastatin Production by<i>Monascus pilosus</i> (2006)

Lovastatin production is dependent on the substrates provided. We investigated how several carbon and nitrogen sources in the medium affect lovastatin production by Monascus pilosus. M. pilosus required a suitable concentration of organic nitrogen peptone for high lovastatin production. As sole carbon source with peptone, although glucose strongly repressed lovastatin production, maltose was responsible for high production. Interestingly, glycerol combined with maltose enhanced lovastatin production, up to 444 mg/l in the most effective case. Moreover, an isolated mutant, in which glucose repression might be relieved, easily produced the highest level of lovastatin, 725 mg/l on glucose-glycerol-peptone medium. These observations indicate that lovastatin production by M. pilosus is regulated by strict glucose repression and that an appropriate release from this repression by optimizing medium composition and/or by a mutation(s) is required for high lovastatin production.
Performance on the Defense Automated Neurobehavioral Assessment across controlled environmental conditions (2016)

Neurocognitive assessment tools (NCAT) are commonly used to screen for changes in cognitive functioning following a mild traumatic brain injury and to assist with a return to duty decision. As such, it is critical to determine if performance on the Defense Automated Neurobehavioral Assessment (DANA) is adversely affected by operationally-relevant field environments. Differences in DANA performance between a thermoneutral environment and three simulated operationally-relevant field environments across the thermal stress continuum were calculated for 16 healthy U.S. Navy service members. Practice effects associated with brief test-retest intervals were calculated within each environmental condition. There were no significant differences between the simulated environmental conditions suggesting that performance on the DANA Brief is not impacted by thermal stress. Additionally, there were no significant differences in performance within each simulated environmental condition associated with repeated administrations.
DeepCGH: 3D computer-generated holography using deep learning (2020)

The goal of computer-generated holography (CGH) is to synthesize custom illumination patterns by modulating a coherent light beam. CGH algorithms typically rely on iterative optimization with a built-in trade-off between computation speed and hologram accuracy that limits performance in advanced applications such as optogenetic photostimulation. We introduce a non-iterative algorithm, DeepCGH, that relies on a convolutional neural network with unsupervised learning to compute accurate holograms with fixed computational complexity. Simulations show that our method generates holograms orders of magnitude faster and with up to 41% greater accuracy than alternate CGH techniques. Experiments in a holographic multiphoton microscope show that DeepCGH substantially enhances two-photon absorption and improves performance in photostimulation tasks without requiring additional laser power.
Visual Attention to Repeated Print Advertising: A Test of Scanpath Theory (1999)

The authors examine consumers’ visual attention during repeated exposures to print advertisements using eye-tracking methodology. The authors propose a statistical model comprising submodels for two key measures of visual attention to elements of the advertisement: attention duration and inter- and intraelement saccades. These measures are vital to understanding attention wear-out and the impact of repetition on advertising effectiveness but have not been considered in previous research. The results of two studies show that (1) attention duration decreases significantly across advertising repetitions and (2) attentional scanpaths, as measured through saccades, remain constant across advertising repetitions and across experimentally induced and naturally occurring conditions. Scanpaths obey a stationary, reversible, first-order Markov process. The authors offer implications for attention theory and advertising processing.
An experimental study on reshaping C110 deformed casing with spinning casing swage (2015)

Casing deformation affects the implementation of stimulation and development measures of oilfields directly; however, the reshaping force and torque usually are determined by experience when the deformed casing is repaired with the spinning reshaping technology; if the repairing force or torque is too large, it will result in the damage of casing and cement sheath as well as sticking accident. So, the collapse experiments were performed on the YAW-200 pressure testing machine by using one production casing which is often used in the oilfield and then the reshaping test of deformed casing (C110) was performed in turn by using two spinning casing swages of which the diameter is 126 mm and 129 mm respectively. The continuous rotator and thrust bearing were used to provide the torque and reshaping force respectively in the repairing process. The reshaping force and torque required to reshape the deformed casing, the deformation law and the springback value of deformed casing were obtained. Test results show that the diameter differential between the two spinning casing swages is reasonable. Furthermore, in order to ensure the safety and reliability of the implementation of post-production technologies, the mechanical properties of deformed casing before and after reshaping were tested. It was found that all the mechanical parameters of the deformed casing after reshaping reduced, which resulted in the decrease of the strength of the reshaped casing. These research achievements would provide important experimental data in optimizing the structure and construction parameters of spinning casing swages.
A novel multifunctional factor involved in trans-splicing of chloroplast introns in Chlamydomonas (2006)

In the chloroplast of Chlamydomonas reinhardtii, psaA mRNA is spliced in trans from three separate precursors which assemble to form two group II introns. A fourth transcript, tscA, completes the structure of the first intron. Of the fourteen nucleus-encoded factors involved in psaA splicing, only two are required for splicing of both introns. We cloned and characterized the first of these more general factors, Raa1. Consistently with its role in psaA splicing, Raa1 is imported in the chloroplast where it is found in a membrane fraction and is part of a large ribonucleoprotein complex. One mutant, raa1-L137H, is defective for splicing of both introns, but another allelic mutant, raa1-314B, still expresses the 3' part of the Raa1 gene and is deficient only in splicing of intron 2. This observation and a deletion analysis indicate the presence of two domains in Raa1. The C-terminal domain is necessary and sufficient for processing of tscA RNA and splicing of the first intron, while the central domain is essential for splicing of the second intron. The combination of these two functional domains in Raa1 suggests that this new factor may coordinate trans-splicing of the two introns to improve the efficiency of psaA maturation.
SNAP: A Software Package for User-Guided Geodesic Snake Segmentation (2003)

Abstract. We present a new software package for interactive segmentation of 3D images by geodesic snakes, with manual editing. Several variants of level set snakes are incorporated, including both gradientmagnitude based snakes as well as region-competition snakes. A complete segmentation pipeline, including image preprocessing, bubble initialization and parameter control, is provided in an intuitive user interface. Slice-based overpainting is also provided in the same framework, for manual editing of the automatic snake segmentation. This tool is already in daily use by clinicians and offers a vast improvement in speed over traditional manual segmentation. We present examples from several clinical studies, as well as validation results comparing the automatic geodesic snakes segmentation with manual expert rater segmentation. 1
Thermodynamic Method of Calculation of the Volume of the Combustion Chamber of a Rocket Engine (1969)

This work contains the theory of calculation of the volume of the combustion chamber of a rocket engine on the basis of the discovered property of rocket fuels in the evaporation process and explosion of the drops of these fuels. This method enables the construction of safe and most economical chambers.
Synthesis and Association Behavior of [4.4.4.4.4.4]Metacyclophanedodecayne Derivatives with Interior Binding Groups (1998)

Intriguing association behavior in solution is exhibited by the rigid macrocycle 1. For instance, it reacts with organic cations to give ternary complexes of the composition (1⋅cation)⋅1, and with analogous macrocycles without cyano groups it forms heteroaggregates. R=CO<sub>2</sub> C<sub>8</sub> H<sub>17</sub> .
The role of the D <sub>2</sub> dopamine receptor (D <sub>2</sub> R) in A <sub>2A</sub> adenosine receptor (A <sub>2A</sub> R)-mediated behavioral and cellular responses as revealed by A <sub>2A</sub> and D <sub>2</sub> receptor knockout mice (2001)

The A(2A)R is largely coexpressed with D(2)Rs and enkephalin mRNA in the striatum where it modulates dopaminergic activity. Activation of the A(2A)R antagonizes D(2)R-mediated behavioral and neurochemical effects in the basal ganglia through a mechanism that may involve direct A(2A)R-D(2)R interaction. However, whether the D(2)R is required for the A(2A)R to exert its neural function is an open question. In this study, we examined the role of D(2)Rs in A(2A)R-induced behavioral and cellular responses, by using genetic knockout (KO) models (mice deficient in A(2A)Rs or D(2)Rs or both). Behavioral analysis shows that the A(2A)R agonist 2-4-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine reduced spontaneous as well as amphetamine-induced locomotion in both D(2) KO and wild-type mice. Conversely, the nonselective adenosine antagonist caffeine and the A(2A)R antagonist 8-(3-chlorostyryl)caffeine produced motor stimulation in mice lacking the D(2)R, although the stimulation was significantly attenuated. At the cellular level, A(2A)R inactivation counteracted the increase in enkephalin expression in striatopallidal neurons caused by D(2)R deficiency. Consistent with the D(2) KO phenotype, A(2A)R inactivation partially reversed both acute D(2)R antagonist (haloperidol)-induced catalepsy and chronic haloperidol-induced enkephalin mRNA expression. Together, these results demonstrate that A(2A)Rs elicit behavioral and cellular responses despite either the genetic deficiency or pharmacological blockade of D(2)Rs. Thus, A(2A)R-mediated neural functions are partially independent of D(2)Rs. Moreover, endogenous adenosine acting at striatal A(2A)Rs may be most accurately viewed as a facilitative modulator of striatal neuronal activity rather than simply as an inhibitory modulator of D(2)R neurotransmission.
Gamut Mapping for Digital Cinema (2014)

To ensure consistent presentation of future wide-gamut digital cinema packages (DCPs) on standard gamut screens, a mandatory gamut mapping strategy has to be chosen. In this paper, current gamut mapping algorithms are evaluated with respect to their application in digital cinema. These algorithms include: “Simple Clip,” “Cusp Clip,” “Minimum delta E” (mindE), “Hue-preserving mindE,” “Weighted mindE,” and the mapping strategy that is used in current projectors. The gamut mapping algorithms under investigation will be provided as three-dimensional (3D) lookup tables for comparison. These can also be used to retrofit a more advanced gamut mapping strategy to standard gamut projectors. Therefore, the paper concludes with an analysis of the losses introduced by using 3D lookup tables for gamut mapping. The intent of this paper is to initiate a discussion about gamut mapping strategies for digital cinema, which may ultimately lead to an addendum to the SMPTE standards for digital cinema.
Remote- and Ground-Based Sensor Techniques to Map Soil Properties (2003)

Farm managers are becoming increasingly aware of the spatial variability in crop production with the growing availability of yield monitors. Often this variability can be related to differences in soil properties (e.g., texture, organic matter, salinity levels, and nutrient status) within the field. To develop management approaches to address this variability, high spatial resolution soil property maps are often needed. Some soil properties have been related directly to a soil spectral response, or inferred based on remotely sensed measurements of crop canopies, including soil texture, nitrogen level, organic matter content, and salinity status. While many studies have obtained promising results, several interfering factors can limit approaches solely based on spectral response, including tillage conditions and crop residue. A number of different ground-based sensors have been used to rapidly assess soil properties “on the go” (e.g., sensor mounted on a tractor and data mapped with coincident position information) and the data from these sensors compliment image-based data. On-the-go sensors have been developed to rapidly map soil organic matter content, electrical conductivity, nitrate content, and compaction. Model and statistical methods show promise to integrate these groundand image-based data sources to maximize the information from each source for soil property mapping.
Suppression of Mouse Melanoma Metastasis by EA-1, A Monoclonal Antibody Specific for α6 Integrins (1993)

The rat monoclonal antibody (mAb) termed EA-1 was originally selected for its capacity to block the adhesion of T lymphocyte progenitors to mouse thymic endothelium. Here we show that the mAb EA-1 recognizes the α6 chain of α6β1 and α6β4 integrins. Both molecules are present at a high level on the luminal and basolateral side of vascular endothelium and α6β1 integrin is expressed on the highly metastatic cell lines B16/129 (melanoma) and KLN-205 (carcinoma). These lung specific tumors bind preferentially to lung frozen sections, and EA-1 blocked this interaction in vitro. Moreover, mAb EA-1 inhibited experimental metastasis to the lung of B16/129 cells injected intravenously. Metastasis in vivo was blocked when the antibody was injected into mice before or simultaneously with the melanoma cells, as well as when melanoma cells were precoated with EA-1 before injection. We suggest that α6 integrins play a dual role in the metastatic process, mediating the adhesion of tumor cells to the luminal surface of the endothelium and the adhesion to laminin in the subendothelial extracellular matrix during extravasation. Despite the fact that α6 integrins are laminin receptors, EA-1 did not interfere with melanoma cell binding to laminin fragments. Our antibody EA-1 may therefore recognize a binding domain on α6 integrins of a novel ligand involved in cell-cell interaction.
The Mechanism for the Induction of Cytochrome P450 2B Subfamily: Progress of Research and Future Problem. (2001)

Research history and recent progress on the mechanism by which xenobiotics induce cytochromes P450 belonging to the CYP2B subfamily are briefly reviewed. One of the major interests focused here is that what is the initial target site for exogenous inducers? In this topics, we discussed the validity of the concept for the receptor-mediated induction, and for a mechanism in which xenobiotic inducers cancel the effect with endogenous suppressors. Recent studies have revealed a crucial role of nuclear receptors, CAR (Constitutive Androstane Receptor) and RXR (Retinoid X-Receptor), in trans-activating a specific region located 5'-Upstream of the CYP2B genes. We also reviewed the role of DNA elements participating in transactivation, and those of the trans-factors involving not only CAR/RXR but also other factors such as Barbie box and RBP-Jκ.