gebhart/patrepeval huggingface dataset:
An Engineering Process for Autonomous Fault Management in Service-Oriented Systems (2010)

Service-Oriented Computing reveals features which are not commonly found in conventional computing paradigms; loose coupling, dynamism, blackbox, evolvability, and heterogeneity. These features make diagnosing and healing faults found in deployed services and service-related elements more challenging than managing conventional systems. Hence, service-oriented systems management often results in problems of increased cost/effort, decreased effectiveness, and irresolvable service faults. Applying key disciplines of autonomic computing to services management would effectively resolve these problems and automate the task. This paper presents a process for managing faults in autonomous manner. We define a whole life-cycle process for managing faults in SOA and the essential artifacts of each phase. Then, we present instructions for carry out each phase. Especially, we propose methods for fault diagnosis and reasoning knowledgebase updates by learning mechanism in detail. The process is not limited to providing a theoretical basis for service management, but it can be practically applied with current service-oriented architecture standards.
A charge-control transistor model for network analysis programs (1968)

A representation is given of an Ebers-Moll model with charge control that employs only standard circuit elements. Storage of carriers associated with current flow is represented with the aid of two current-controlled voltage generators.
Photocatalytic activity of nanostructured TiO<sub>2</sub>‐modified white cement (2011)

In this study, the photocatalysis of Alphazurine FG as a model water pollutant, by white Portland cement samples modified with different TiO2 nanomaterials (TiO2 in the form of Degussa P25, Millennium PC500, Millennium PC105 and anatase-Merck), was investigated. The pseudo first-order rate constants of Alphazurine FG photocatalysis were compared with the degradation rate by unmodified cement sample. A significant enhancement of the photocatalytic activity due to the addition of TiO2 nanomaterials in the form of Degussa P25 to Portland cement was observed. The crystalline phase, average crystalline size and surface area of the photocatalyst were found to have a significant influence on the photocatalytic activity of the nanostructured TiO2-modified cement samples. The photocatalysis of Alphazurine FG in the presence of TiO2–P25/cement was experimentally studied through changing the UV light intensity and initial dye concentration. The electrical energy consumption of Alphazurine FG photocatalysis was estimated at different initial dye concentrations. The results open important perspective applications in the field of eco-friendly construction applications.
Design methodologies for partially reconfigured systems (2002)

Run time reconfiguration (RTR) as an implementation approach that divides an application into a series of sequentially executed stages with each stage implemented as a separate circuit module. Partial RTR extends this approach by partitioning these stages and designing their circuit modules such that they exhibit a high degree of functional and physical commonality. Transitioning between configurations can then be accomplished by updating only the differences between configurations. This reduces the amount of time that an RTR application spends configuring and significantly enhances overall performance. The paper presents the design methodology for partial RTR in the context of RRANN2, a partial RTR artificial neural network.
Determination of Scutellarin in <i>Scutellaria barbata</i> Extract by Liquid Chromatography–Electrochemical Detection (2003)

Abstract A rapid and simple method was developed for the determination of scutellarin in Scutellaria barbata plant extracts by reversed‐phase liquid chromatography with an electrochemical detector (ECD). The potential electrode voltage was +0.7 V for the ECD. The mobile phase consisted of methanol:water:glacial acetic acid (30:68:2, v/v/v) (pH 2.7). The linear calibration ranged from 2.3 to 150.0 µg mL−1 for scutellarin. The detection limit was 0.2 µg mL−1 given a signal‐to‐noise ratio (S/N) of 3:1 on the second detection fullscale (500 nA). The six different extracts of S. barbata were determined using different extraction methods and extraction solvents. The contents of scutellarin in the extracts were determined within 25 min. Keywords: ScutellarinLiquid chromatographyElectrochemical detection
Textiles trade and the developing countries : eliminating the multifibre arrangement in the 1990s (1990)

The papers contained in this volume deal with two central issues. The first is the positive question of the effects of the Multifibre Arrangement (MFA) on developing countries. The second is the normative question of how to phase out the MFA and integrate textiles and clothing trade in the normal GATT rules in the context of the current Uruguay Round of multilateral trade negotiations. The major effects of the MFA considered are the direct, trade-restricting effects of the bilateral quotas, their effects on prices of textiles and clothing in restricted and unrestricted markets, and hence on national and global welfare; the effects on fiber trade; the various inefficiencies introduced by the MFA and its administration; and finally, the implications of the arrangement for growth in the developing economies. These effects are discussed at a general level in the first part of this report. The second part contains a discussion of the effects of the MFA on particular countries. In considering the options for reforming the MFA, it was recognized that the successive arrangements reflected the pressures placed on governments by powerful interest groups, and that these pressures had to be taken into account in formulating proposals for policy reform. In this context a wide range of reform proposals was considered.
Hepatitis C Virus Infection, Linxian, China1 (2005)

Bloodborne viruses may have spread in rural China during the past 25 years, but population-based prevalence estimates are lacking. We examined the frequency of hepatitis C virus (HCV) and HIV type 1 (HIV-1) among residents of Linxian, a rural community in Henan Province. In 2000, blood was collected from participants (> or = 55 years of age) who had enrolled in a population-based nutritional intervention trial in 1985. We randomly selected 500 participants for HCV testing and 200 participants for HIV-1 testing. For HCV, 48 (9.6%) of 500 participants were positive by enzyme immunoassay and recombinant immunoblot assay (95% confidence interval, 7.0%-12.2%), and prevalence was lowest in the most geographically isolated participants. Among the HCV-infected participants, 42 had a specimen available from 1985, of which 16 (38.1%) were positive for HCV. For HIV-1, 0/200 participants were positive. We conclude that HCV is now a common infection among older adults in Linxian, China.
O montepio e sua incidência no teto remuneratório (2011)

O presente trabalho realiza uma analise historica e jurisprudencial do extinto Montepio, promovendo um debate acerca das questoes pertinentes a sua natureza juridica e forma de extincao sem a devida observância dos direitos de seus benefiiarios. Considera-se este um tema relevante, uma vez que as consequencias oriundas da extincao desse beneficio tem gerado, ha tempos, discussao e divergencia, tanto na doutrina quanto na jurisprudencia.
New short peptaibols from a marine <i>Trichoderma</i> strain (2006)

The production of peptaibols by a marine-related Trichoderma longibrachiatum strain was studied using electrospray ionisation multiple-stage ion trap mass spectrometry (ESI-MSn-IT) and gas chromatography/electron impact mass spectrometry (GC/EI-MS). Two major groups of peptaibols were identified, those with long sequences (20 amino acids) and others with short sequences (11 amino acids). This paper describes the methodology used to establish the sequences of short peptaibols in a mixture without previous individual separation. Nine peptaibols were identified. Among them, eight are new, namely as trichobrachin A I-IV (Aib9-Pro10 sequence) and as trichobrachin B I-IV (Val9-Pro10 sequence). Original Pro6-Val7 and Val9-Pro10 sequences have to be noted.
Strategies for Identifying RNA Splicing Regulatory Motifs and Predicting Alternative Splicing Events (2008)

Strategies for Identifying RNA Splicing Regulatory Motifs and Predicting Alternative Splicing Events
Bifunctional enzyme FBPase/SBPase is essential for photoautotrophic growth in cyanobacterium Synechocystis sp. PCC 6803 (2008)

From a random insertion mutant library of Synechocystis sp. PCC 6803, a mutant defective in photoautotrophic growth was obtained. The interrupted gene was identified to be slr2094 (fbp1), which encodes the fructose-1,6-biphosphatase (FBPase)/sedoheptulose-1,7-biphosphatase (SBPase) bifunctional enzyme (F-I). Two other independently constructed slr2094 mutants showed an identical phenotype. The FBPase activity was found to be virtually lacking in an slr2094 mutant, which was sensitive to light under mixotrophic growth conditions. These results indicate that slr2094 is the only active FBPase-encoding gene in this cyanobacterium. Inactivation of photosystem II by interrupting psbB in slr2094 mutant alleviated the sensitiveness to light. This report provides the direct genetic evidence for the essential role of F-I in the photosynthesis of Synechocystis sp. PCC 6803.
New Alkaloids from <i>Cephalotaxus </i><i>f</i><i>ortunei</i> (2002)

Four new cephalotaxus alkaloids, cephalotaxine alpha-N-oxide (1), cephalotaxine beta-N-oxide (2), 11-beta-hydroxycephalotaxine beta-N-oxide (3), and isocephalotaxine (4), were isolated, together with several known alkaloids from an EtOAc extract of the fruits of Cephalotaxus fortunei. The structures were determined by spectral analysis including mass spectrometry and 2D NMR. Compounds 1, 2, 3, and 4 displayed cytotoxicity against nasopharynx KB cells with IC50 values of 30, 14, 31, and 15 micro g/mL, respectively.
Biobutanol - production and purification methods (2011)

The prospective of depletion of natural resources, petroleum products and rising prices of raw materials tend to look for fuels from renewable energy sources and biofuels. The focus so far has been put on bioethanol due to the availability of raw materials for its production and well-developed methods for isolation and purification. Butyl alcohol biobutanol can be regarded as a potential biofuel. Biobutanol is a very attractive energy source because as opposed to bioethanol is non-hygroscopic, does not cause corrosion and has a higher calorific value. Production of butanol may be made by a fermentation process called ABE (acetone, butanol, ethanol), carried out mostly by bacteria Clostridium acetobutylicum. The basic problem of wider use of biobutanol depends on its production with sufficient efficiency and this in turn is limited by separation of butanol from fermentation broth. The distillation process is not applicable. The classical extraction requires the use of a flammable or toxic liquid. For separation and purification of biobutanol it is proposed to apply ionic liquids. Use of ionic liquids for the extraction of butanol (to remove from the fermentation environment) can be achieved either through direct application of the liquid in the bioreactor and separation of butanol outside of bioreactor or directing fermentation broth outside the bioreactor and separation of butanol in the membrane contractor.
Tyrosine Residue in Exon 14 of the Cytoplasmic Domain of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) Regulates Ligand Binding Specificity (1997)

Platelet/endothelial cell adhesion molecule (PECAM-1) is a cell adhesion molecule of the immunoglobulin superfamily that plays a role in a number of vascular processes including leukocyte transmigration through endothelium. The presence of a specific 19- amino acid exon within the cytoplasmic domain of PECAM-1 regulates the binding specificity of the molecule; specifically, isoforms containing exon 14 mediate heterophilic cell-cell aggregation while those variants missing exon 14 mediate homophilic cell-cell aggregation. To more precisely identify the region of exon 14 responsible for ligand specificity, a series of deletion mutants were created in which smaller regions of exon 14 were removed. After transfection into L cells, they were tested for their ability to mediate aggregation. For heterophilic aggregation to occur, a conserved 5-amino acid region (VYSEI in the murine sequence or VYSEV in the human sequence) in the mid-portion of the exon was required. A final construct, in which this tyrosine was mutated into a phenylalanine, aggregated in a homophilic manner when transfected into L cells. Inhibition of phosphatase activity by exposure of cells expressing wild type or mutant forms of PECAM-1 to sodium orthovanadate resulted in high levels of cytoplasmic tyrosine phosphorylation and led to a switch from heterophilic to homophilic aggregation. Our data thus indicate either loss of this tyrosine from exon 14 or its phosphorylation results in a change in ligand specificity from heterophilic to homophilic binding. Vascular cells could thus determine whether PECAM-1 functions as a heterophilic or homophilic adhesion molecule by processes such as alternative splicing or by regulation of the balance between tyrosine phosphorylation or dephosphorylation. Defining the conditions under which these changes occur will be important in understanding the biology of PECAM-1 in transmigration, angiogenesis, development, and other processes in which this molecule plays a role.
Epitaxially-grown graphite on silicon carbide, pyrolitic graphite and graphene: a Raman scattering study (2007)

The results of micro-Raman scattering measurements performed on three different ``graphitic'' materials: micro-structured disks of highly oriented pyrolytic graphite, graphene multi-layers thermally decomposed from carbon terminated surface of 4H-SiC and an exfoliated graphene monolayer are presented. Despite its multi-layer character, most parts of the surface of the graphitized SiC substrates shows a single-component, Lorentzian shape, double resonance Raman feature in striking similarity to the case of a single graphene monolayer. Our observation suggests a very weak electronic coupling between graphitic layers on the SiC surface, which therefore can be considered to be graphene multi-layers with a simple (Dirac-like) band structure.
THE EFFECT OF PREGNANT MARE'S SERUM GONADOTROPHIN AND HUMAN CHORIONIC GONADOTROPHIN ON THE WET AND DRY OVARIAN WEIGHT OF IMMATURE RATS (1966)

Summary. The effect of the administration of 50 i.u. pregnant mare's serum gonadotrophin (pmsg) alone or the same dosage of this hormone followed 72 hr later by 25 i.u. human chorionic gonadotrophin (hcg) on ovarian wet and dry weight has been investigated in three colonies of rats of the Wistar strain. Alterations in the ratio of the wet to dry ovarian weight were noted following treatment of pmsg; these were less marked after hcg administration. The maximum ovarian weight obtained following hormonal treatment varied between the three colonies of rats but the pattern of response was similar. The results did not appear to be influenced by the body weight of the animals. It is suggested that differences in ovarian weight between the three rat colonies may influence the results obtained in the ovarian ascorbic acid depletion (oaad) and ovarian cholesterol depletion (ocd) tests.
Characterization of Distinct Nuclear and Mitochondrial Forms of Human Deoxyuridine Triphosphate Nucleotidohydrolase (1996)

Deoxyuridine triphosphate nucleotidohydrolase (dUTPase; EC 3.6.1.23) was purified from HeLa cells by immunoaffinity chromatography. Based on SDS-polyacrylamide gel electrophoresis, two distinct forms of dUTPase were evident in the purified preparation. These proteins were further characterized by a combination of NH2-terminal protein sequencing, mass spectrometry, and mass spectrometry-based protein sequencing. These analyses indicate that the two forms of dUTPase are largely identical, differing only in a short region of their amino-terminal sequences. Despite the structural difference, both forms of dUTPase exhibited identical binding characteristics for dUTP. Each form of dUTPase has a distinct cellular localization. Cellular fractionation and isopycnic density centrifugation indicate that the lower molecular weight form of dUTPase (DUT-N) is associated with the nucleus, while the higher molecular weight species (DUT-M) fractionates with the mitochondria. The DUT-N isoform is approximately 30-fold more abundant in HeLa cells than DUT-M as determined by densitometry. The NH2-terminal protein sequence of both DUT-N and DUT-M did not match previous reports of the predicted amino-terminal sequence for human dUTPase (McIntosh, E.M., Ager, D.D., Gadsden, M.H., and Haynes, R.H. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 8020-8024; Strahler, J.R., Zhu X., Hora, N., Wang, Y.K., Andrews, P.C., Roseman, N.A., Neel, J.V., Turka, L., and Hanash, S.M. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 4991-4995). A cDNA corresponding to the DUT-N isoform was isolated utilizing an oligonucleotide probe based on the determined NH2-terminal sequence. The cDNA contains a 164-amino acid open reading frame, encoding a protein of Mr 17,748. The DUT-N cDNA sequence matches the previously cloned cDNAs with the exception of a few discrepancies in the 5' end. Our data indicate a 69-base pair addition to the 5' end of the previously reported open reading frame.
A New Algorithm for Gradient Field Integration (2001)

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Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein (2004)

Aurora-A kinase is necessary for centrosome maturation, for assembly and maintenance of a bipolar spindle, and for proper chromosome segregation during cell division. Aurora-A is an oncogene that is overexpressed in multiple human cancers. Regulation of kinase activity apparently depends on phosphorylation of Thr-288 in the T-loop. In addition, interactions with targeting protein for Xenopus kinesin-like protein 2 (TPX2) allosterically activate Aurora-A. The Thr-288 phosphorylation is reversed by type-1 protein phosphatase (PP1). Mutations in the yeast Aurora, Ipl1, are suppressed by overexpression of Glc8, the yeast homolog of phosphatase inhibitor-2 (I-2). In this study, we show that human I-2 directly and specifically stimulated recombinant human Aurora-A activity in vitro. The I-2 increase in kinase activity was not simply due to inhibition of PP1 because it was not mimicked by other phosphatase inhibitors. Furthermore, activation of Aurora-A was unaffected by deletion of the I-2 N-terminal PP1 binding motif but was eliminated by deletion of the I-2 C-terminal domain. Aurora-A and I-2 were recovered together from mitotic HeLa cells. Kinase activation by I-2 and TPX2 was not additive and occurred without a corresponding increase in T-loop phosphorylation. These results suggest that both I-2 and TPX2 function as allosteric activators of Aurora-A. This implies that I-2 is a bifunctional signaling protein with separate domains to inhibit PP1 and directly stimulate Aurora-A kinase.
Prevalence and clinical correlates of pathological affective display in Alzheimer's disease. (1995)

This study examined the prevalence and correlates of pathological affect in Alzheimer's disease. A consecutive series of 103 patients with Alzheimer's disease were examined with a comprehensive psychiatric assessment that included the pathological laughing and crying scale (PLACS). Forty patients (39%) showed pathological affect: 25% showed crying episodes, and 14% showed laughing or mixed (laughing and crying) episodes. Patients with pathological affect crying showed significantly higher depression scores and a significantly higher frequency of major depression and dysthymia than patients with no pathological affect. Patients with mixed pathological affect showed significantly more subcortical atrophy on CT than patients with pathological affect crying. Forty seven per cent of the patients with pathological affect had no congruent mood disorder, and they showed a significantly longer duration of illness and more severe anosognosia than patients with pathological affect that was congruent with an underlying mood disorder. The study validates the PLACS, and shows the high prevalence of pathological affect in Alzheimer's disease.
A Comparison of Buyer-Determined and Price-Based Multiattribute Mechanisms (2007)

Reverse auctions are fast becoming the standard for many procurement activities. In the past, the majority of such auctions have been solely price based, but increasingly attributes other than price affect the auction outcome. Specifically, the buyer uses a scoring function to compare bids and the bid with the highest score wins. We investigate two mechanisms commonly used for procurement in business-to-business markets, in a setting in which buyers' welfare is affected by exogenous nonprice attributes such as the quality, service, and past relationships. Under both mechanisms, bidders bid based on price, but in the “buyer-determined” mechanism, the buyer is free to select the bid that maximizes her surplus while in the “price-based” mechanism, the buyer commits to awarding the contract to the low price bidder. We find, both in theory and in the laboratory, that the “buyer-determined” mechanism increases the buyer's welfare only as long as enough suppliers compete. If the number of suppliers is small and the correlation between cost and quality is low, the buyer is better off with the “price-based” mechanism. These findings are intended to help procurement managers make better decisions in designing procurement mechanisms for a variety of settings.
Molecular genetic markers in diagnosis of lung cancer (2011)

The review considers the main approaches to the identification of lung cancer (LC) markers, including genetic, epigenetic, protein, transcriptomic, proteomic, metabolic, and miRNA markers. Emphasis is placed on epigenetic markers, which are the most promising because epigenetic changes are among the earliest events in malignant transformation. Special attention is given to circulating tumor markers, which can be detected in easily accessible biological fluids with minimally invasive methods and may be useful for screening the risk groups for LC, diagnosing cancer before its clinical manifestation, monitoring the tumor in remission after therapy, and verifying the diagnosis based on standard clinical and instrumental methods of diagnostics. Extracellular nucleic acids (circulating in blood, circNA) are highlighted as a potential source of material for early diagnosis of LC, prediction of the efficiency of antitumor treatment, posttreatment monitoring, and disease prognosis.