gebhart/patrepeval huggingface dataset:
Glycoprotein 130 Signaling Regulates<i>Notch1</i>Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells (2003)

Glycoprotein130 (gp130) and Notch signaling are thought to participate in neural stem cell (NSC) self-renewal. We asked whether gp130 regulates Notch activity in forebrain epidermal growth factor (EGF)-responsive NSCs. Disruption of Notch1 using antisense or a gamma-secretase inhibitor demonstrated a requirement for Notch1 in the maintenance and proliferation of NSCs. Ciliary neurotrophic factor (CNTF) activation of gp130 in NSCs rapidly increased Notch1 expression. NOTCH1 activation, indicated by tumor necrosis factor alpha-converting enzyme (TACE)- and presenilin-mediated processing, also increased. Infusion of EGF+CNTF into adult forebrain lateral ventricles increased periventricular NOTCH1 compared with EGF alone. Neither Hes1 (hairy and enhancer of split) nor Hes5 appeared to mediate gp130-enhanced NOTCH1 signaling that regulates NSC maintenance. This is the first example of a link between gp130 signaling and NOTCH1 in regulating NSC self-renewal.
Observation of elemental anomalies at the surface of palladium after electrochemical loading of deuterium or hydrogen (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTObservation of elemental anomalies at the surface of palladium after electrochemical loading of deuterium or hydrogenDebra R. Rolison and William E. O'GradyCite this: Anal. Chem. 1991, 63, 17, 1697–1702Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/ac00017a009https://doi.org/10.1021/ac00017a009research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Aqueous Polysaccharide Associations Mediated by β-Cyclodextrin Polymers (2008)

Macromolecular assemblies were elaborated by mixing in water hydrophobically modified dextrans (MDC(n)) and beta-cyclodextrin polymers (pbetaCD) interacting by inclusion complexation between the hydrophobic moieties of MDCn and the beta-cyclodextrin cavities of pbetaCD. Dextrans have been modified by grafting alkyl groups (C(n)) of varying chain lengths (n = 8-16) and grafting ratio (3-6 mol%). Different pbetaCD polymers were synthesized by polycondensation of beta-cyclodextrin and epichlorohydrin. The polymer-polymer interactions have been studied by fluorimetry, isothermal titration microcalorimetry, phase diagrams, and viscosimetry. The viscoelastic properties of the temporary networks (in the semidilute range) have been studied by rheology. The interaction mechanisms between the MDCn and pbetaCD can be understood taking into account the strength of the interaction between the alkyl group and the beta-cyclodextrin cavity (mainly controlled by the alkyl chain length), the density of junctions between the chains (depending on the alkyl grafting density and the pbetaCD molecular weight), and additional cooperative effect (arising for high alkyl grafting density).
Monitoring Bacterial Twitter: Does Quorum Sensing Determine the Behavior of Water and Wastewater Treatment Biofilms? (2012)

Bacteria have their own form of "twitter" communication, described as quorum sensing (QS), where bacteria emit and sense chemical signal molecules as a means to gauge population density and control gene expression. Many QS-controlled genes relate to biofilm formation and function and may be important for some water and wastewater treatment biofilms. There is a need to better understand bacterial QS, the bacteria biofilm aspects influenced by QS in engineered reactors, and to assess how designs and operations might be improved by taking this signaling into account. This paper provides a critical review of QS and how it relates to biofilms in engineered water and wastewater treatment systems and identifies needs for future research.
HVAC SYSTEM DESIGN AUTOMATION: ISSUES, METHODS, AND ULTIMATE LIMITS (2001)

We have developed software applications that design HVAC systems (that is, select, locate, and size components and their interconnections) given building descriptions, user preferences, and built-in rules. When this capability is combined with other key application characteristics (graphic interface, interactive recalculation, full integration, self-contained reference data, strict retention of user modifications, and automatic parts selection), the result is a powerful assistant that greatly increases user productivity and design quality. Our application structure is a framework for iterative improvements in design and analysis algorithms and the addition of optimization techniques. We see this type of software ultimately replacing most design functions now performed by people.
Effect of Parainfluenza-3 Virus Neuraminidase on the Structure of the Gel Phase of Bovine Nasal Secretion (1974)

The gel phase of bovine nasal secretion was separated from the liquid phase and exposed to parainfluenza-3 virus or Vibrio cholerae neuraminidase under optimal in vitro conditions. N-Acetylneuraminic acid was released from the gel by either neuraminidase. The release of N-acetylneuraminic acid was accompanied by a decrease in the net negative charge of the gel, as evidenced by free zone electrophoresis. Scanning electron microscopy showed that after exposure to neuraminidases the regular network structure of the untreated gel attained a coarse, irregular structure. Samples of gel incubated with 0.15 M sodium chloride under similar conditions did not show changes in the net charge or morphology.
Application of the cobaltabisdicarbollide anion to the development of ion selective PVC membrane electrodes for tuberculosis drug analysis (2008)

The cobaltabisdicarbollide anion is used as a new material able to generate an ion-pair complex used for PVC membrane ion selective electrodes.
Bonding Trends and Dimensionality Crossover of Gold Nanoclusters on Metal-Supported MgO Thin Films (2006)

Bonding of gold clusters, , 16, and 20, on MgO(100) and on thin MgO films supported on Mo(100) is investigated using first-principles density-functional theory. Enhanced adhesive bonding is found for clusters deposited on metal-supported MgO films of thickness up to about 1 nm, or 4 to 5 MgO layers, originating from electrostatic interaction between the underlying metal and metal-induced excess electronic charge accumulated at the cluster interface with the oxide film. The increased wetting propensity is accompanied by a dimensionality crossover from three-dimensional optimal cluster geometries on MgO(100) to energetically favored two-dimensional structures on the metal-supported films.
Mal-Netminer: Malware Classification Approach Based on Social Network Analysis of System Call Graph (2015)

As the security landscape evolves over time, where thousands of species of malicious codes are seen every day, antivirus vendors strive to detect and classify malware families for efficient and effective responses against malware campaigns. To enrich this effort and by capitalizing on ideas from the social network analysis domain, we build a tool that can help classify malware families using features driven from the graph structure of their system calls. To achieve that, we first construct a system call graph that consists of system calls found in the execution of the individual malware families. To explore distinguishing features of various malware species, we study social network properties as applied to the call graph, including the degree distribution, degree centrality, average distance, clustering coefficient, network density, and component ratio. We utilize features driven from those properties to build a classifier for malware families. Our experimental results show that “influence-based” graph metrics such as the degree centrality are effective for classifying malware, whereas the general structural metrics of malware are less effective for classifying malware. Our experiments demonstrate that the proposed system performs well in detecting and classifying malware families within each malware class with accuracy greater than 96%.
An Efficient Route to Either Enantiomer of<i>trans</i>-2-Aminocyclopentanecarboxylic Acid (2001)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTAn Efficient Route to Either Enantiomer of trans-2-Aminocyclopentanecarboxylic AcidPaul R. LePlae, Naoki Umezawa, Hee-Seung Lee, and Samuel H. GellmanView Author Information Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706-1396 [email protected]Cite this: J. Org. Chem. 2001, 66, 16, 5629–5632Publication Date (Web):July 11, 2001Publication History Received12 March 2001Published online11 July 2001Published inissue 1 August 2001https://doi.org/10.1021/jo010279hCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1796Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (59 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Molecular structure,Reaction products,Redox reactions,Transfer reactions Get e-Alerts
Preparation, Optimization and Evaluation of Chitosan-Based Avanafil Nanocomplex Utilizing Antioxidants for Enhanced Neuroprotective Effect on PC12 Cells (2021)

(1) Introduction: in recent decades, interdisciplinary research on the utilization of natural products as "active moiety carriers" was focused on due to their superior safety profile, biodegradability, biocompatibility and the ability for sustained or controlled release activity. The nano-based neuroprotective strategy is explored as an imperative treatment for diabetic neuropathy (DN). Avanafil (AV), that selectively inhibits the degradation of cGMP-specific phosphodiesterase, thereby increasing the levels of cGMP, makes a decisive mediator for cytoprotection. (2) Methods: AVnanocomplex formulations were prepared by a modified anti-solvent precipitation method and the method was optimized by Box-Behnken design. An optimized formulation was characterized and evaluated for various in vitro parameters; (3) results:based on the desirability approach, the formulation containing 2.176 g of chitosan, 7.984 g of zein and 90% <i>v/v</i> ethanol concentration can fulfill the prerequisites of optimum formulation (OB-AV-NC).OB-AV-NC was characterized and evaluated for various parameters. The neuroprotective mechanism of AV was evaluated by pretreatment of PC12 cells with plain AV, avanafil nanocomplex (NC) without antioxidants (AV-NC) and with antioxidants (α-Lipoic acid LP; Ellagic Acid EA), AV-LP-EA-Nanocomplex has also shown considerable attenuation in intracellular reactive oxygen species (ROS) and lipid peroxidation with a significant increase in the PC 12 viability under HG conditions in comparison to pure AV; (4) conclusion: the nanocomplex of AV prepared to utilize natural polymers and antioxidants aided for high solubility of AV and exhibited desired neuroprotective activity.This can be one of the promisingstrategy to translate the AV nanocomplex with safety and efficacy in treating DN.
Investigation of H2 S and CO2 Removal from Gas Streams Using Hollow Fiber Membrane Gas–liquid Contactors (2017)

Chemical absorption of H 2 S and CO 2 from CH 4 was carried out in a polypropylene porous asymmetric hollow fiber membrane contactor (HFMC). A 0.5 mol L -1 aqueous solution of methyldiethanolamine (MDEA) was used as chemical absorbent solution. Effects of gas flow rate, liquid flow rate, H 2 S concentration and CO 2 concentration on the H 2 S outlet concentrations and CO 2 removal percentage were investigated.
Diastereo- and Enantioselective Construction of Spirocycles by Nickel-Catalyzed Cascade Borrowing Hydrogen Cyclization (2020)

Spirocycles play an important role in drug discovery and development owing to their inherent three-dimensionality and structural novelty. Despite the recent significant progress, the straightforward catalytic asymmetric assembly of spirocyclic scaffolds with multiple stereocenters from readily available starting materials remains a formidable challenge. Herein, we develop an unprecedented nickel-catalyzed one-pot synthesis of enantioenriched spiroindanones from easily available 1,6-enynes and <i>o</i>-formylarylboronic acids. The reaction proceeds smoothly under redox-neutral conditions, without the need for an additional hydrogen donor, and features a broad substrate scope and excellent regio-, enantio-, and diastereoselectivity.
Bi-, Tri-, and Polycyclic Acylphloroglucinols from <i>Hypericum empetrifolium</i> (2012)

The ¹H NMR-guided fractionation of a petroleum ether extract of Hypericum empetrifolium led to the isolation of four new bicyclic (1-4), four known bicyclic (5-8), three new tricyclic (9-11), and three new polycyclic acylphloroglucinols (12/13 and 14) possessing a monoterpenoid citran moiety. Compounds 12/13 were isolated as a mixture of two inseparable structural isomers. The compounds showed in vitro antiproliferative activity against human microvascular endothelial cells (HMEC-1) with IC₅₀ values in the range 9.2 ± 2.0 to 29.6 ± 3.5 μM.
Localization and Quantification of Circular DNA in Yeast (1974)

Saccharomyces cerevisiae contains 62 molecules per cell of a class of covalently closed circular DNA termed omicron ( o DNA) of buoyant density 1.701 g/cm 3 with a major size class of 1.9 μm. The localization of o DNA has been investigated in a respiratory deficient mutant 2eρ −1 containing altered mitochondrial DNA (ρDNA) in the form of covalently closed circles. There are 81 ρDNA molecules per cell and they range in size from 0.05 μm to 1.6 μm and have a buoyant density of 1.676 g/cm 3 . When this mini‐circular ρDNA is used as a marker of cytoplasmic contamination, we find that purified nuclei do not contain o DNA. We conclude from the cytoplasmic location of o DNA that it does not represent a gene amplification product nor is it related to “informosomal” DNA.
Knockdown of FUSE binding protein 1 enhances the sensitivity of epithelial ovarian cancer cells to carboplatin (2017)

Epithelial ovarian cancer (EOC) affects almost 25,000 women annually and is the fifth most common malignancy in women in North America. A combination of surgery and cytotoxic chemotherapy may produce a favorable clinical response. The platinum-paclitaxel combination regimen is the chemotherapy gold-standard for advanced ovarian cancer, and carboplatin is one of the agents in this combination therapy. However, the majority of patients eventually experience a relapse due to the development of platinum resistance. FUSE binding protein 1 (FBP1) has been identified as an anti-apoptotic and pro-proliferative oncoprotein that is overexpressed in hepatocellular carcinoma. Its high expression is also associated with carboplatin resistance. In the present study, it was identified that the expression of FBP1 was significantly higher in EOC tissues than in normal epithelial ovarian or in epithelial ovarian adenoma tissue. FBP1 expression was significantly correlated with the grade of epithelial ovarian cancer. Carboplatin inhibited the expression of FBP1 in epithelial ovarian cancer cells and the knockdown of FBP1 enhanced the inhibition of cell viability and migration by carboplatin. In addition to FBP1, carboplatin also inhibited the expression of β-catenin and matrix metalloproteinase (MMP)-9. Furthermore, the expression of β-catenin and MMP-9 were lower in FBP1 knockdown cells compared with control EOC cells. FBP1 may thus serve a role in the regulation of the expression of β-catenin and MMP-9; the inhibition of β-catenin and MMP-9 by carboplatin may be mediated through the inhibition of FBP1. The inhibition of FBP1 expression by carboplatin may be a mechanism in the treatment of EOC by carboplatin.
Advanced Interfaces for Vehicle Teleoperation: Collaborative Control, Sensor Fusion Displays, and Web-based Tools (2000)

LSRO
Bias-enhanced nucleation of highly oriented diamond on titanium carbide (111) substrates (1995)

The bias-enhanced nucleation (BEN) technique has been applied to TiC(111) substrates and resulted in deposition of oriented diamond particles. The orientation was observed via scanning electron microscopy. A dense region of oriented particles was not observed on the samples, presumably due to the excessive twinning of the diamond. However, micrographs taken throughout the substrate showed diamond particles having similar orientation with respect to each other. Some of the diamond particles showed evidence of azimuthal twist and tilting, resulting most likely from the ∼21% lattice mismatch. Raman spectra of the diamond crystals show a strong feature at 1332 cm−1, which is indicative of diamond, and smaller features at 1480 and 1602 cm−1 due to sp2-bonded carbon.
Modification of Surfaces and Interfaces by Non-covalent Assembly of Hybrid Linear−Dendritic Block Copolymers:  Poly(benzyl ether) Dendrons as Anchors for Poly(ethylene glycol) Chains on Cellulose or Polyester (1999)

Solution and interfacial properties of water-soluble hybrid linear−dendritic polyether copolymers are investigated by static and dynamic surface tension measurements and adsorption experiments on polymeric substrates. The results obtained show that the block copolymers are able to form mono- and multimolecular aggregates in water. Contacting a solid polymeric substrate with an aqueous solution of hybrid block copolymer increases the hydrophilicity of the substrate. Adsorption on the hydrophobic surface of poly(ethylene terephthalate) proceeds only through the dendritic blocks of the hybrid macromolecule. For more hydrophilic substrates such as regenerated cellulose, both the poly(ethylene glycol) tail and the poly(benzyl ether) dendrons adsorb on the surface, increasing its hydrophilicity.
Modified Repair of a Defect in Spondylolysis or Minimal Spondylolisthesis by Pedicle Screw, Segmental Wire Fixation, and Bone Grafting (1993)

A surgical technique for treatment of spondylolysis or minimal isthmic spondylolisthesis is described. The authors based their treatment on the Scott technique, which involves placing an 18-gauge stainless steel wire around the transverse process bilaterally and then tightening the wires to each other inferiorly to the posterior spinal process. The modified technique consists of a tension band wire around the posterior spinous process and a 4.5 mm AO cortical screw in the pedicle. A case study of a 20-year old female athletic student is presented to illustrate the effectiveness of the modified technique. The authors believe that this technique offers the advantages of maintaining all motion segments and avoiding the risks of damaging the exciting nerve root just beneath the transverse process.
Family Planning in Asia. (1970)

In this article the medical director of IPPF, Dr. Malcolm Potts, reviews some new aspects of family planning as discussed in a regional IPPF conference in 1970 in Tokyo and as he gathered impressions from his travels in Asia. Nearly all Asian countries have governmental family planning programs. However, for the most part, bottlenecks have developed in these programs, and the achievements have been disappointing. The population in Asia is biased towards the younger age groups. Migration makes only a marginal difference. Unemployment is a serious social program which will be magnified by additional labor force. Japan has demonstrated that legal abortion can be a relatively safe procedure while in Korea induced abortion is illegal. Conversely, in Korea oral contraceptives have been successfully distributed in the governmental program while in Japan the method is still not approved by the government. A bill to reform the abortion law is before the Indian parliament. In Mainland China, IUDs, oral contraceptives and condoms are in use; sterilization and abortion are available upon request.
A new approach to massive blood transfusion during pediatric liver resection. (1986)

Morbidity and death during liver resection in children are due to hemorrhage and the consequences of massive transfusion. To overcome these problems, a new rapid method of blood transfusion was used in four children (8 to 35 months, 8.6 to 13 kg) undergoing extensive hepatic resection for tumor (tumor weight, 440 to 1625 gm). The rapid infusion device consisted of a roller pump and a bubble oxygenator-warmer circuit primed with washed packed red cells resuspended in fresh-frozen plasma and calcium-free balanced salt solution (Plasmalyte). The infusate was warmed, oxygenated, and buffered before it was administered. An average of 5130 ml per patient of this reconstituted blood was infused at an average rate of 122 +/- 45 ml/min, with peak infusion rates sometimes as great as 1 L/min. Cardiac output, pulmonary artery wedge pressure, body temperature, urine output, blood gases, blood chemistries, and coagulation factors remained unchanged during and after these massive transfusions. Blood transfusion at rapid rates required during pediatric liver resection can be accomplished safely if the storage lesion of the bank blood is previously corrected.
An OpenMP runtime profiler/configuration tool for dynamic optimization of the number of threads (2016)

This paper describes the implementation and the experimental results of a tool for dynamic configuration of the number of threads used in the OpenMP environment based on the current state of the runtime at the time of the call. For this purpose, we use a mix of profiling and machine learning techniques to determine the number of threads. The decision to set the number of threads is made at the time of the call. The proposed approach is designed to be cost effective in the scenario of a highly dynamic runtime primarily when running relatively long tasks consisting of a number of parallel constructs.