gebhart/patrepeval huggingface dataset:
The roles of cell adhesion molecules in tumor suppression and cell migration (2009)

In addition to mediating cell adhesion, many cell adhesion molecules act as tumor suppressors. These proteins are capable of restricting cell growth mainly through contact inhibition. Alterations of these cell adhesion molecules are a common event in cancer. The resulting loss of cell-cell and/or cell-extracellular matrix adhesion promotes cell growth as well as tumor dissemination. Therefore, it is conventionally accepted that cell adhesion molecules that function as tumor suppressors are also involved in limiting tumor cell migration. Paradoxically, in 2005, we identified an immunoglobulin superfamily cell adhesion molecule hepaCAM that is able to suppress cancer cell growth and yet induce migration. Almost concurrently, CEACAM1 was verified to co-function as a tumor suppressor and invasion promoter. To date, the reason and mechanism responsible for this exceptional phenomenon remain unclear. Nevertheless, the emergence of these intriguing cell adhesion molecules with conflicting roles may open a new chapter to the biological significance of cell adhesion molecules.
Wavelength tuning of fiber Bragg gratings over 90 nm using a simple tuning package (2003)

We demonstrate a silica-based tunable fiber Bragg grating filter with a wavelength tuning range over 90 nm. A bend-tuning technique in a simple tuning package is employed to obtain a wide wavelength tuning range from 1634 to 1544 nm, covering the entire L-band and a half of the C-band. The polarization-mode dispersion and polarization-dependent loss of the device show little variations over the whole operating region.
Hydrophobic Components in Delipidated Granule of Egg Yolk (1982)

Journal Article Hydrophobic Components in Delipidated Granule of Egg Yolk Get access Tomomi Tsutsui, Tomomi Tsutsui Seitoku Junior College of Nutrition, 1-4-6 Nishishinkoiwa, Katsushika-ku, Tokyo 124, Japan Search for other works by this author on: Oxford Academic Google Scholar Tetsujiro Obara Tetsujiro Obara Department of Agricultural Chemistry, Tokyo University of Agriculture, Tokyo 156, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 46, Issue 10, 1 October 1982, Pages 2587–2589, https://doi.org/10.1080/00021369.1982.10865476 Published: 01 October 1982 Article history Received: 14 January 1982 Published: 01 October 1982
Generating representative Web workloads for network and server performance evaluation (1998)

One role for workload generation is as a means for understanding how servers and networks respond to variation in load. This enables management and capacity planning based on current and projected usage. This paper applies a number of observations of Web server usage to create a realistic Web workload generation tool which mimics a set of real users accessing a server. The tool, called Surge (Scalable URL Reference Generator) generates references matching empirical measurements of 1) server file size distribution; 2) request size distribution; 3) relative file popularity; 4) embedded file references; 5) temporal locality of reference; and 6) idle periods of individual users. This paper reviews the essential elements required in the generation of a representative Web workload. It also addresses the technical challenges to satisfying this large set of simultaneous constraints on the properties of the reference stream, the solutions we adopted, and their associated accuracy. Finally, we present evidence that Surge exercises servers in a manner significantly different from other Web server benchmarks.
Prophylactic Use of Factor VIII: an Economic Evaluation (1998)

Reductions in non-factor health care costs and disability associated with prophylactic use of factor VIII in hemophilia were substantial and helped somewhat to offset the much higher costs of this regimen. For certain subgroups, frequent episodic treatment may be more expensive than full-time prophylaxis. However, because of the very high cost of year-round prophylactic use of factor VIII, total health care expenditures were highest among patients receiving this therapeutic regimen. However, because prophylaxis clearly offers important clinical benefits, this approach may be warranted on medical rather than economic grounds.
A note off two binary signaling alphabets (1956)

A generalization of Hamming's single error correcting codes is given along with a simple maximum likelihood detection scheme. For small redundancy these alphabets are unexcelled. The Reed-Muller alphabets are described as parity check alphabets and a new detection scheme is presented for them.
Oxidative cleavage of mono-, di-, and trisubstituted olefins to methyl esters through ozonolysis in methanolic sodium hydroxide (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidative cleavage of mono-, di-, and trisubstituted olefins to methyl esters through ozonolysis in methanolic sodium hydroxideJames A. Marshall and Albert W. GarofaloCite this: J. Org. Chem. 1993, 58, 14, 3675–3680Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://doi.org/10.1021/jo00066a019RIGHTS & PERMISSIONSArticle Views1737Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (736 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Interactive phenotyping of large-scale histology imaging data with HistomicsML (2017)

Whole-slide imaging of histologic sections captures tissue microenvironments and cytologic details in expansive high-resolution images. These images can be mined to extract quantitative features that describe tissues, yielding measurements for hundreds of millions of histologic objects. A central challenge in utilizing this data is enabling investigators to train and evaluate classification rules for identifying objects related to processes like angiogenesis or immune response. In this paper we describe HistomicsML, an interactive machine-learning system for digital pathology imaging datasets. This framework uses active learning to direct user feedback, making classifier training efficient and scalable in datasets containing 10<sup>8</sup>+ histologic objects. We demonstrate how this system can be used to phenotype microvascular structures in gliomas to predict survival, and to explore the molecular pathways associated with these phenotypes. Our approach enables researchers to unlock phenotypic information from digital pathology datasets to investigate prognostic image biomarkers and genotype-phenotype associations.
Sitagliptin reduces albuminuria in patients with type 2 diabetes [Rapid Communication] (2010)

We investigated the inhibitory effect of sitagliptin on albuminuria in patients with type 2 diabetes. Thirty-six patients (19 men and 17 women) whose HbA1c was higher than 6.5% (NGSP) despite receiving education on diet and exercise and medical treatment for at least 6 months at our clinic were enrolled into this study and were successfully followed over 6 months of sitagliptin treatment. Sitagliptin (50 mg/day) treatment significantly lowered both systolic and diastolic blood pressures, fasting blood glucose and postprandial blood glucose, HbA1c, and glycated albumin at 3 months and 6 months. Significant reductions in highly sensitive C-reactive protein and soluble vascular cell adhesion molecule 1 were also observed at 6 months. Urinary albumin excretion (measured as urinary albumin-to-creatinine ratio (ACR: mg/g Cr)) did not change in the 6 months before sitagliptin treatment (ΔACR: 2.3 ± 19.9) and decreased in the 6 months after sitagliptin treatment (ΔACR: -20.6 ± 24.6); these differences were statistically significant. At 6 months, the ACR decreased from 11.6 ± 8.4 to 4.5 ± 5.0 in 13 patients with normoalbuminuria (ACR < 30), from 98.4 ± 79 to 24.9 ± 20 in 15 patients with microalbuminuria (30 < ACR < 300), and from 1263 ± 492 to 561 ± 89 in 8 patients with macroalbuminuria (ACR > 300). Thus, the present findings strongly suggest that sitagliptin reduces albuminuria without lowering the estimated glomerular filtration rate, most likely depending on known factors such as blood sugar reduction, blood pressure reduction, and inflammation reduction, as well as yet undetermined factors caused by an increase in active glucagon-like peptide-1.
Antibiotics and probiotics in inflammatory bowel disease: why, when, and how (2009)

Recent literature provides increasing support for the use of antibiotics in Crohn's disease, although the side effects limit their long-term use. The efficacy of antibiotics in ulcerative colitis is not confirmed by the available literature, except in severe colitis. More trials are needed to support the use of probiotics as therapy in inflammatory bowel disease.
Complementation between avirulent Newcastle disease virus and a fusion protein gene expressed from a retrovirus vector: requirements for membrane fusion (1991)

The cDNA derived from the fusion gene of the virulent AV strain of Newcastle disease virus (NDV) was expressed in chicken embryo cells by using a retrovirus vector. The fusion protein expressed in this system was transported to the cell surface and was efficiently cleaved into the disulfide-linked F1-F2 form found in infectious virions. The cells expressing the fusion gene grew normally and could be passaged many times. Monolayers of these cells would plaque, in the absence of trypsin, avirulent NDV strains (strains which encode a fusion protein which is not cleaved in tissue culture). Fusion protein-expressing cells would not fuse if mixed with uninfected cells or uninfected cells expressing the hemagglutinin-neuraminidase (HN) protein. However, the fusion protein-expressing cells, if infected with avirulent strains of NDV, would fuse with uninfected cells, suggesting that fusion requires both the fusion protein and another viral protein expressed in the same cell. Fusion was also seen after transfection of the HN protein gene into fusion protein-expressing cells. Thus, the expressed fusion protein gene is capable of complementing the virus infection, providing an active cleaved fusion protein required for the spread of infection. However, the fusion protein does not mediate cell fusion unless the cell also expresses the HN protein. Fusion protein-expressing cells would not plaque influenza virus in the absence of trypsin, nor would influenza virus-infected fusion protein-expressing cells fuse with uninfected cells. Thus, the influenza virus HA protein will not substitute for the NDV HN protein in cell-to-cell fusion.
PMD Compensator and PMD Emulator (2003)

As a technology for increasing the capacity to meet the growing demand for communications in recent years, dense wavelength-division multiplexing (DWDM) is being implemented in tandem with achieving higher transmission rates on each channel. At next-generation transmission rates of 40 Gbps, it is expected that polarization mode dispersion (PMD) will be the main factor in the deterioration of transmission characteristics. Both first-order PMD and higher-order PMD can affect the performance of a high-speed optical transmission system. A PMD emulator capable of generating PMD up to the second-order is useful in estimating the performance degradation due to PMD and in optimizing the devices that compensate for this type of degradation. The present work is a programmable device based on variable Faraday rotators (VFRs) that is capable of emulating first-order and two components of second-order PMD. Various PMD conditions can be generated by the emulator and the measured values agree with theoretical simulations. Further, we propose a much simpler configuration for the PMD compensator (PMDC) with higher-order PMD canceller (HOPC), unifying the monitor sections of the PMDC and HOPC into one power monitor. Test results for our configuration in a 10-Gbps evaluation system are also reported.
Linux system programming (2008)

Write software that draws directly on services offered by the Linux kernel and core system libraries. With this comprehensive book, Linux kernel contributor Robert Love provides you with a tutorial on Linux system programming, a reference manual on Linux system calls, and an insider's guide to writing smarter, faster code. Love clearly distinguishes between POSIX standard functions and special services offered only by Linux. With a new chapter on multithreading, this updated and expanded edition provides an in-depth look at Linux from both a theoretical and applied perspective over a wide range of programming topics, including: A Linux kernel, C library, and C compiler overview Basic I/O operations, such as reading from and writing to files Advanced I/O interfaces, memory mappings, and optimization techniques The family of system calls for basic process management Advanced process management, including real-time processes Thread concepts, multithreaded programming, and Pthreads File and directory management Interfaces for allocating memory and optimizing memory access Basic and advanced signal interfaces, and their role on the system Clock management, including POSIX clocks and high-resolution timers
Metformin in prevention and treatment of antipsychotic induced weight gain: a systematic review and meta-analysis (2016)

This meta-analysis confirms that metformin is effective in treating antipsychotic induced weight gain in patients with schizophrenia or schizoaffective disorder.
Water Gas Shift Reaction on Cu and Au Nanoparticles Supported on CeO<sub>2</sub>(111) and ZnO(000$\bar 1$): Intrinsic Activity and Importance of Support Interactions (2007)

A cerious contender: The catalytic activity in the water gas shift reaction of Au and Cu nanoparticles supported on CeO2(111) is superior to that of these nanoparticles on a ZnO(000) support or of the bulk metals (the diagram shows the results depending on the Au nanoparticle coverage). These results illustrate the essential role that an oxide can have in the activity of supported Au nanocatalysts.
Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression (2013)

Berberine efficiently radiosensitized NPC cells and xenografts in mice, and inhibited hypoxia/radiation-induced up-regulation of HIF-1α and VEGF expression.
Macular pigment in monozygotic twins (1994)

Differences in the optical density of macular pigment between ten pairs of identical twins were examined. Foveal and parafoveal sensitivities to lights of 460 and 530 nm were measured by heterochromatic flicker photometry in five separate sessions for the right eye of each twin. These two wavelengths represent the maximum and minimum absorbance for macular pigment. Taking the difference in log sensitivity to the 460 nm light for the fovea and parafovea, after normalizing with respect to 530 nm, yields a measurement of the optical density of macular pigment. Statistically significant differences in macular pigment density were found for five of the ten twin pairs. These differences were then related to differences in the carotenoid content of the subject's serum (as measured by reverse-phase high-performance liquid chromatography) and differences in the dietary intake of carotenoids (as assessed by a dietary questionnaire). While only a small relationship was found between differences in macular pigment density and the serum and dietary carotenoids that compose macular pigment (lutein and zeaxanthin), a systematic relationship was found between macular pigment density and a number of other diet variables that influence carotenoid metabolism. Taken together, the data support earlier research on the importance of diet in determining macular pigment levels. However, it is likely that this relationship is complex and that the eventual deposition of macular pigment within the eye is influenced by a number of other diet variables rather than simply carotenoid intake.
Specific expression of haptoglobin mRNA in implantation-stage rabbit uterine epithelium (1997)

A glycoprotein, termed GP42, was previously identified in uterine fluid obtained from peri-implantation-stage rabbits. N-terminus amino acid sequencing of purified GP42 demonstrated identity through the first 13 amino acids with the beta subunit of liver haptoglobin. The present study was undertaken to determine if GP42 is indeed identical to haptoglobin and, if so, to determine whether it is expressed in the uterus as opposed to being present as a transudate from plasma. Reverse transcription-PCR amplification of poly(A)+ RNA prepared from implantation-stage rabbit endometrium with GP42- and haptoglobin-specific primers yielded a predicted 667 bp cDNA product. Sequence analysis of the cloned cDNA confirmed the identity of GP42 with beta-haptoglobin. Northern blot analysis demonstrated the specific expression of haptoglobin mRNA in the peri-implantation-stage endometrium and the absence of its expression in the estrous or day 4 pseudopregnant endometrium. Non-isotopic in situ hybridization revealed that the haptoglobin mRNA was restricted to the epithelium lining the luminal surface and mucosal folds of day 6(3/4) pregnant or pseudo-pregnant uteri and that no haptoglobin mRNA was detectable in the epithelium of the deep glands or cells of the stroma or myometrium. Similarly, in situ hybridization revealed no expression of haptoglobin mRNA in any cell types of the estrous uterus. These data establish the identity of GP42 with beta-haptoglobin and demonstrate that it is expressed in a stage-specific manner just prior to implantation, correlating with uterine receptivity to blastocyst implantation. Endometrial GP42 mRNA expression is not dependent on the presence of blastocysts.
Mechanical behavior of additive manufactured, powder-bed laser-fused materials (2015)

Mechanical behavior of four metallic alloys fabricated with layered, laser-heated methods of additive manufacturing (AM) was compared to that of similar alloys produced with conventional methods (wrought and machined). AM materials were produced by a leading commercial service provider, as opposed to incorporating material specimens produced by unique or specially-adapted equipment. The elastic moduli were measured in flexure, stress–strain characteristics were measured in tensile deformation, and fatigue strengths were measured in fully reversed bending. The effects of fabrication orientation, surface polishing, and hot isostatic pressing upon mechanical behavior were studied. The fatigue strengths exhibited by SLM AlSi10Mg and DMLS Ti6Al4V in the as-fabricated condition proved to be significantly inferior to that of conventional material. These lower fatigue strengths are a consequence of multiple fatigue cracks initiating at surface defects, internal voids and microcracks, and growing simultaneously during cyclic loading. Measured fatigue strengths of DMLS 316L and 17-4PH approached those of corresponding wrought materials when subjected to principal stresses aligned with the build planes. When cyclic stresses were applied across the build planes of the DMLS stainless steels, fatigue fractures often developed prematurely by separation of material. Post-processing the DMLS Ti6Al4V and SS316L with hot isostatic pressure elevated the fatigue strength significantly. Measurements of surface roughness with an optical profilometer, examinations of the material microstructures, and fractography contribute to an understanding of the mechanical behavior of the additive materials.
Nonnodulating Bradyrhizobium spp. Modulate the Benefits of Legume-Rhizobium Mutualism (2016)

Rhizobia are soil bacteria best known for their capacity to form root nodules on legume plants and enhance plant growth through nitrogen fixation. Yet, most rhizobia in soil do not have this capacity, and their effects on this symbiosis are poorly understood. We investigated the effects of diverse nonnodulating rhizobia on a native legume-rhizobium symbiosis. Nonnodulating strains did not affect plant growth in isolation. However, compared to inoculations with symbiotic rhizobia, coinoculations of symbiotic and nonnodulating strains often reduced plant and symbiont fitness. Coinoculation increased host performance only under one extreme treatment. Nonnodulating strains also invaded nodule interiors in the presence of nodulating strains, but this did not affect the fitness of either partner. Our data suggest that nonnodulating strains may be important competitors at the root-soil interface and that their capacity to attenuate this symbiosis should be considered in efforts to use rhizobia as biofertilizers.
Self-digitization chip for quantitative detection of human papillomavirus gene using digital LAMP (2019)

Digital nucleic acid amplification and detection methods provide excellent sensitivity and specificity and allow absolute quantification of target nucleic acids. Isothermal methods such as digital loop-mediated isothermal amplification (digital LAMP) have potential for use in rapid disease diagnosis in low-resource settings due to their speed and lack of thermal cycling. We previously developed a self-digitization (SD) chip, a simple microfluidics device that automatically digitizes a sample into an array of nanoliter wells, for use in digital LAMP. In this work, we improve the SD chip design to increase sample loading efficiency, speed, and completeness, and test a range of well volumes and numbers. We demonstrate the diagnostic capability of this platform by applying it to quantifying human papillomavirus 18 gene.
Copper Sulfide Nanoparticles with Phospholipid‐PEG Coating for In Vivo Near‐Infrared Photothermal Cancer Therapy (2014)

In this work, small sizes of hydrophobic copper sulfide nanoparticles (CuS NPs, ∼3.8 nm in diameter) have been successfully prepared from the reaction of copper chloride with sodium diethyldithiocarbamate (SDEDTC) inside a heated oleylamine solution. These CuS NPs displayed strong absorption in the 700-1100 nm near-infrared (NIR) region. By coating CuS NPs with DSPE-PEG2000 on the surface, the as-synthesized CuS@DSPE-PEG NPs exhibited good water solubility, significant stability and biocompatibility, as well as excellent photothermal conversion effects upon exposure to an 808 nm laser. After intravenous administration to mice, the CuS@DSPE-PEG NPs were found to passively target to the tumor site, and tumor tissues could be ablated efficiency under laser irradiation. In addition, CuS@DSPE-PEG NPs do not show significant toxicity by histological and blood chemistry analysis, and can be effectively excreted via metabolism. Our results indicated that CuS@DSPE-PEG NPs can act as an ideal photothermal agent for cancer photothermal therapy.