gebhart/patrepeval huggingface dataset:
Flowcube: constructing RFID flowcubes for multi-dimensional analysis of commodity flows (2006)

With the advent of RFID (Radio Frequency Identication) technology, manufacturers, distributors, and retailers will be able to track the movement of individual objects throughout the supply chain. The volume of data generated by a typical RFID application will be enormous as each item will generate a complete history of all the individual locations that it occupied at every point in time, possibly from a specific production line at a given factory, passing through multiple warehouses, and all the way to a particular checkout counter in a store. The movement trails of such RFID data form gigantic commodity flowgraph representing the locations and durations of the path stages traversed by each item. This commodity flow contains rich multi-dimensional information on the characteristics, trends, changes and outliers of commodity movements.In this paper, we propose a method to construct a warehouse of commodity flows, called flowcube. As in standard OLAP, the model will be composed of cuboids that aggregate item flows at a given abstraction level. The flowcube differs from the traditional data cube in two major ways. First, the measure of each cell will not be a scalar aggregate but a commodity flowgraph that captures the major movement trends and significant deviations of the items aggregated in the cell. Second, each flowgraph itself can be viewed at multiple levels by changing the level of abstraction of path stages. In this paper, we motivate the importance of the model, and present an efficient method to compute it by (1) performing simultaneous aggregation of paths to all interesting abstraction levels, (2) pruning low support path segments along the item and path stage abstraction lattices, and (3) compressing the cube by removing rarely occurring cells, and cells whose commodity flows can be inferred from higher level cells.
Compact Ridge Waveguide Filters With Arbitrarily Placed Transmission Zeros Using Nonresonating Nodes (2009)

Compact size ridge waveguide filters based on the nonresonating node concept are introduced to realize transfer functions with arbitrarily placed attenuation poles. Coupling mechanisms, suitable for the new realization are introduced in diverse <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</i> -plane and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> -plane configurations and with different input-output interfaces. These coupling structures are studied and characterized in detail in order to simplify the design of the proposed filters. Rigorous mode-matching method is used to accelerate the full-wave design of the filter configurations, whose response is also verified using other numerical techniques and experimental data. To validate the proposed novel designs, a prototype has been built and tested. Measurement results agree well with the predicted theoretical simulations.
Structural equation modelling of human judgement (2001)

Structural equation modelling (SEM) is outlined and compared with two non-linear alternatives, artificial neural networks and “fast and frugal” models. One particular non-linear decision-making situation is discussed, that exemplified by a lexicographic semi-order. We illustrate the use of SEM on a dataset derived from 539 volunteers' responses to questions about food-related risks. Our conclusion is that SEM is a useful member of the armoury of techniques available to the student of human judgement: it subsumes several multivariate statistical techniques and permits their flexible combination, and it provides robust goodness-of-fit statistics and is available in (generally) easy-to-use computer packages. Although the number of tasks for which SEM provides a persuasive psychological model is small, it is very useful in identifying the important variables and their inter-relations that contribute to task performance, and thus can constitute a valuable intermediate staging point between raw data and a fully fledged psychological theory.
Interactive Storyboard for Overall Time-Varying Data Visualization (2008)

Large amounts of time-varying datasets create great challenges for users to understand and explore them. This paper proposes an efficient visualization method for observing overall data contents and changes throughout an entire time-varying dataset. We develop an interactive storyboard approach by composing sample volume renderings and descriptive geometric primitives that are generated through data analysis processes. Our storyboard system integrates automatic visualization generation methods and interactive adjustment procedures to provide new tools for visualizing and exploring time-varying datasets. We also provide a flexible framework to quantify data differences and automatically select representative datasets through exploring scientific data distribution features. Since this approach reduces the visualized data amount into a more understandable size and format for users, it can be used to effectively visualize, represent, and explore a large time-varying dataset. Initial user study results show that our approach shortens the exploration time and reduces the number of datasets that users visualized individually. This visualization method is especially useful for situations that require close observance or are not capable of interactive rendering, such as documentation and demonstration.
Pyronaridine Protects against SARS-CoV-2 Infection in Mouse (2022)

There are currently relatively few small-molecule antiviral drugs that are either approved or emergency-approved for use against severe acute respiratory coronavirus 2 (SARS-CoV-2). One of these is remdesivir, which was originally repurposed from its use against Ebola. We evaluated three molecules we had previously identified computationally with antiviral activity against Ebola and Marburg and identified pyronaridine, which inhibited the SARS-CoV-2 replication in A549-ACE2 cells. The <i>in vivo</i> efficacy of pyronaridine has now been assessed in a K18-hACE transgenic mouse model of COVID-19. Pyronaridine treatment demonstrated a statistically significant reduction of viral load in the lungs of SARS-CoV-2-infected mice, reducing lung pathology, which was also associated with significant reduction in the levels of pro-inflammatory cytokines/chemokine and cell infiltration. Pyronaridine inhibited the viral PL<sup>pro</sup> activity <i>in vitro</i> (IC<sub>50</sub> of 1.8 μM) without any effect on M<sup>pro</sup>, indicating a possible molecular mechanism involved in its ability to inhibit SARS-CoV-2 replication. We have also generated several pyronaridine analogs to assist in understanding the structure activity relationship for PL<sup>pro</sup> inhibition. Our results indicate that pyronaridine is a potential therapeutic candidate for COVID-19.
The Spectral Energy Distributions Produced by Rotary Mixing of Complementary Papers (1924)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Deane B. Judd, "The Spectral Energy Distributions Produced by Rotary Mixing of Complementary Papers," J. Opt. Soc. Am. 9, 95-111 (1924) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Falling for Fake News (2018)

In the so called 'post-truth' era, characterized by a loss of public trust in various institutions, and the rise of 'fake news' disseminated via the internet and social media, individuals may face uncertainty about the veracity of information available, whether it be satire or malicious hoax. We investigate attitudes to news delivered by social media, and subsequent verification strategies applied, or not applied, by individuals. A survey reveals that two thirds of respondents regularly consumed news via Facebook, and that one third had at some point come across fake news that they initially believed to be true. An analysis task involving news presented via Facebook reveals a diverse range of judgement forming strategies, with participants relying on personal judgements as to plausibility and scepticism around sources and journalistic style. This reflects a shift away from traditional methods of accessing the news, and highlights the difficulties in combating the spread of fake news.
Analysis of the Ostwald Color System* (1944)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Carl E. Foss, Dorothy Nickerson, and Walter C. Granville, "Analysis of the Ostwald Color System*," J. Opt. Soc. Am. 34, 361-381 (1944) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A self-backgating GaAs MESFET model for low-frequency anomalies (1990)

A self-backgating GaAs MESFET model which can simulate low-frequency anomalies has been developed by including deep-level trap effects. These cause transconductance reduction due to electron emission from EL2 in the depletion width change at the edge of the Schottky gate junction and the output conductance to increase due to the time-dependent net negative charge concentration in the semi-insulating substrate as a result of self-backgating with the applied signal frequency. This model has been incorporated in PSPICE and includes a time-dependent I-V curve model, a capacitance model, an RC network describing the effective substrate-induced capacitance and resistance, and a switching resistance providing device symmetry. An analytical capacitance model describes the dependence of capacitance on V/sub gs/ and V/sub ds/ and includes the channel-substrate junction modulation by the self-backgating effect. A transit-time delay is also included in the transconductances, g/sub m/ and g/sub mbs/, for model accuracy and to describe the phase shift of S-parameters. Measured data correspond to simulations by this model of the low-frequency anomalous characteristics, voltage-dependent capacitances, and S-parameters of conventional GaAs MESFETs for linear and microwave circuit design.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Integrated treatment strategies in panic disorder with agoraphobia and depressive disorder]. (1995)

Two patients suffering from a panic disorder (agoraphobia) as well as a depressive disorder and alcohol abuse showed marked improvement when given a combination of pharmacotherapy and behavior therapy. The feasibility of this combination treatment in the context of understanding both the theory and therapy of panic disturbances is discussed in these two case histories.
Multiplex Detection and SNP Genotyping in a Single Fluorescence Channel (2012)

Probe-based PCR is widely used for SNP (single nucleotide polymorphism) genotyping and pathogen nucleic acid detection due to its simplicity, sensitivity and cost-effectiveness. However, the multiplex capability of hydrolysis probe-based PCR is normally limited to one target (pathogen or allele) per fluorescence channel. Current fluorescence PCR machines typically have 4-6 channels. We present a strategy permitting the multiplex detection of multiple targets in a single detection channel. The technique is named Multiplex Probe Amplification (MPA). Polymorphisms of the CYP2C9 gene (cytochrome P450, family 2, subfamily C, polypeptide 9, CYP2C9*2) and human papillomavirus sequences HPV16, 18, 31, 52 and 59 were chosen as model targets for testing MPA. The allele status of the CYP2C9*2 determined by MPA was entirely concordant with the reference TaqMan® SNP Genotyping Assays. The four HPV strain sequences could be independently detected in a single fluorescence detection channel. The results validate the multiplex capacity, the simplicity and accuracy of MPA for SNP genotyping and multiplex detection using different probes labeled with the same fluorophore. The technique offers a new way to multiplex in a single detection channel of a closed-tube PCR.
Normal Structure, Function, and Histology of Lymph Nodes (2006)

Lymph nodes are traditionally regarded as having three compartments, the cortex, paracortex and medulla. B and T cells home to separate areas within these compartments, interact with antigen presenting cells, and undergo clonal expansion. This paper provides structural and functional details about how the lymph node brings lymphocytes and antigen presenting cells together. The concept of the lymphoid lobule as the basic functional and anatomic unit of the lymph node is developed and utilized to provide a framework for understanding lymph node pathobiology. Understanding the histomorphologic features of the lymphoid lobule and the role of the reticular meshwork scaffolding of the lymph node and how these related to the cortex, paracortex and medulla provides a unique approach to understanding lymph node structure and function.
Three-dimensional optimal perturbations in viscous shear flow (1992)

Transition to turbulence in plane channel flow occurs even for conditions under which modes of the linearized dynamical system associated with the flow are stable. In this paper an attempt is made to understand this phenomena by finding the linear three-dimensional perturbations that gain the most energy in a given time period. A complete set of perturbations, ordered by energy growth, is found using variational methods. The optimal perturbations are not of modal form, and those which grow the most resemble streamwise vortices, which divert the mean flow energy into streaks of streamwise velocity and enable the energy of the perturbation to grow by as much as three orders of magnitude. It is suggested that excitation of these perturbations facilitates transition from laminar to turbulent flow. The variational method used to find the optimal perturbations in a shear flow also allows construction of tight bounds on growth rate and determination of regions of absolute stability in which no perturbation growth is possible.
A New Hybrid SSD Architecture Based on SLC and MLC (2014)

In this study, we present a novel internally hybrid SSD architecture (SMARC) which consists of both SLC and MLC flash memory packages, instead of only either SLC or MLC. By periodically migrating data between the two different portions (SLC and MLC space) according to running workloads dynamics, the proposed architecture is able to exploit their respective advantages complementarily to help overall performance, reliability and energy consumption. Our simulation results of a variety of workloads have shown that SMARC can improve the performance by nearly an order of magnitude, at the same time, significantly enhancing reliability and reducing energy consumption.
A High Performance Elevation Phased Array Antenna for the MLS - System (1991)

A high performance MLS-phased-array design is presented using high resolution 6-bit phase shifters for the beam steering instead of the commonly used 4 bit phase resolution. Due to the small phase tolerances and the equivalently low amplitude tolerances this design produces not only systematically lower sidelobes but also a very small beam pointing error allowing smaller MLS-antennas having much wider beamwidths without the penalty of a reduced MLS system accuracy. Hence, this design provides a cost effective MLS-phased array having an inherently high MLS accuracy and high multipath immunity and, also, an inherently improved frangibility. All these characteristics are decisively important at least for CAT III operations on high traffic and difficult site airports. Some typical measured antenna pattern results of the realized elevation antenna are presented.
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. (2011)

Innate lymphoid cells (ILCs), a heterogeneous cell population, are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized. Here we identify a population of lung-resident ILCs in mice and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) receptor a-chain (CD25), IL-7 receptor a-chain (CD127) and the IL-33 receptor subunit T1-ST2. Notably, mouse ILCs accumulated in the lung after infection with influenza virus, and depletion of ILCs resulted in loss of airway epithelial integrity, diminished lung function and impaired airway remodeling. These defects were restored by administration of the lung ILC product amphiregulin. Collectively, our results demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus.
Swine interferon. I. Induction in porcine cell cultures with viral and synthetic inducers. (1972)

The production of interferon by porcine kidney (PK(15)) cell culture in response to viral and synthetic inducers was studied. The inducers used included a synthetic double-stranded polyribonucleotide, polyriboinosinic-polyribocytidylic acid (Poly I:C), swine influenza virus and three strains of pseudorabies virus. Following exposure to these inducers cell culture fluids were examined for interferon by the plaque-reduction method. The Poly I:C and the swine influenza virus induced production of interferon by PK(15) cell cultures, whereas, all three strains of pseudorabies virus at the two concentrations tested failed to induce production of interferon in vitro. The antiviral substance produced in PK(15) cells was identified as an interferon because it was pH stable, non-dialyzable, sensitive to trypsin, non-sedimentable, relatively heat stable, host-species specific and it possessed broad-spectrum antiviral activity. The latter was demonstrated by inhibition of vesicular stomatitis, vaccinia and pseudorabies viruses. Differences in interferon activity against the different viruses were observed.
The effects of irradiation on blood components (1981)

The functional properties of formed elements of whole blood were studied following irradiation doses of 500 to 20,000 rads. Irradiated lymphocytes retained only 1.5 per cent of their 3H thymidine uptake after a 5,000-rad exposure and none after 7,500 rads. Red blood cells stored for 21 days and then irradiated with 5,000 rads had the same survival as nonirradiated controls. In contrast, 5,000 rads reduced platelet yields. However, transfused irradiated platelets produced the expected increases in platelet counts and controlled hemostasis in thrombocytopenic patients. After 5,000 rads, granulocytes had normal bacterial killing capacity, chemotactic mobility, and normal superoxide production after high-dose stimulation. Nitroblue tetrazolium reduction and ingestion stimulated by complement opsonized oil droplets were not diminished by 5,000- and 10,000-rad irradiation. The functional qualities of cellular blood components other than lymphocytes are not compromised by 5,000 rads. This irradiation dose may be an effective means of controlling incidence of graft-vs-host disease in immunosuppressed patients.
Solutions to shape and topology eigenvalue optimization problems using a homogenization method (1992)

Abstract A solution strategy to find the shape and topology of structures that maximize a natural frequency is presented. The methodology is based on a homogenization method and the representation of the shape of the structure as a material property. The problem is formulated as a reinforcement problem in which a given structure is reinforced using a prescribed amount of material. Two dimensional, plane elasticity problems are considered. Examples are presented for illustration.
Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote”<i>Pouteria mammosa</i>(L.) Cronquist (2015)

The common use of Pouteria mammosa (L.) Cronquist, "Mamey or Zapote," in food and ethnobotanic medicine shows its low or absent toxicity as fruit extracts prepared from seeds. However, it is essential to conduct security trials to scientifically support their use in drug therapy. This study evaluated the aqueous and hydroalcoholic extract (25%) Acute Oral Toxicity, obtained from the seeds of P. mammosa, in Sprague Dawley rats and dermal and eye irritability in New Zealand rabbits. The 404 and 405 acute dermal and eye irritation/corrosion guidelines were used, as well as the 423 Acute Oral Toxicity guideline, Acute Toxic Class Method of the Organization for Economic Cooperation and Development (OECD). The aqueous extract was located in the following category: not classified as toxic (CTA 5), while hydroalcoholic extract at 25% was classified as dangerous (CTA 4). Both extracts can be used without side reaction that irritates the skin which permitted classification as potentially not irritant. P. mammosa in the two extracts caused mild and reversible eye irritation, and it was classified as slightly irritating.
Regulation of Aquaporin-4 Water Channels by Phorbol Ester-dependent Protein Phosphorylation (1998)

The molecular mechanisms for regulating water balance in many tissues are unknown. Like the kidney, the eye contains multiple water channel proteins (aquaporins) that transport water through membranes, including two (AQP1 and AQP4) in the ciliary body, the site of aqueous humor production. However, because humans with defective AQP1 are phenotypically normal and because the ocular application of phorbol esters reduce intraocular pressure, we postulated that the water channel activity of AQP4 may be regulated by these agents. We now report that protein kinase C activators, phorbol 12,13-dibutyrate, and phorbol 12-myristate 13-acetate strongly stimulate the phosphorylation of AQP4 and inhibit its activity in a dose-dependent manner. Phorbol 12,13-dibutyrate (10 microM) and phorbol 12-myristate 13-acetate (10 nM) reduced the rate of AQP4-expressing oocyte swelling by 87 and 92%, respectively. Further, phorbol 12,13-dibutyrate significantly increased the amount of phosphorylated AQP4. These results demonstrate that protein kinase C can regulate the activity of AQP4 through a mechanism involving protein phosphorylation. Moreover, they suggest important potential roles for AQP4 in several clinical disorders involving rapid water transport such as glaucoma, brain edema, and swelling of premature infant lungs.
Monitoring and predicting defect densities in a high volume manufacturing facility for increasing yields (1995)

As integrated circuit (IC) market requirements drive technology advance within the semiconductor manufacturing sector, reuse of available high yielding established processes is a cost effective method of achieving a quick response to market requirements. Defect density numbers are regularly calculated for different products as a monitor of process and product performance. For new product introductions to an established process flow, the defect density target is usually assumed to be close to other products running on the same process. To give a better indication of expected defect density, modelling was performed on volume production over several months. Inline defectivity monitor data was extracted along with final-yield results for several products running on one established flow. Mask area data was also extracted far each layer and for critical areas. Critical area data was determined by performing boolean operations on mask layers. This modelling highlighted a method of being able to predict a more accurate defect density number for a new product and in addition could be used to specify the allowed percentage of killer defects at automatic inspection steps within the process flow, per product. (3 pages)