gebhart/patrepeval huggingface dataset:
Hybrid Hexagonal/Classical Tiling for GPUs (2014)

Time-tiling is necessary for the efficient execution of iterative stencil computations. Classical hyper-rectangular tiles cannot be used due to the combination of backward and forward dependences along space dimensions. Existing techniques trade temporal data reuse for inefficiencies in other areas, such as load imbalance, redundant computations, or increased control flow overhead, therefore making it challenging for use with GPUs.
Heterodimerization of the and β Chains of the Interleukin-3 (IL-3) Receptor Is Necessary and Sufficient for IL-3–Induced Mitogenesis (1999)

The high-affinity receptor for interleukin-3 (IL-3) is a complex of the IL-3–binding subunit (IL-3) and a larger β chain—βc, or, in the mouse, βc or its close relative βIL-3. There is evidence that the critical event that initiates signaling is not the approximation of the cytoplasmic domains of IL-3 and βIL-3, but is, rather, the formation of a β-β homodimer. Many of these studies involved the analyses of receptor chimeras where the cytoplasmic domains were derived from IL-3, βc or βIL-3, and the extracellular domains were derived from other cytokine receptors, such as the erythropoietin receptor (EpoR). However, evidence that the EpoR may also associate with other receptors clouds the interpretation of these experiments. Therefore, we reevaluated the structure of the functional IL-3R using chimeric receptors with extracellular domains derived not from members of the cytokine-receptor family, but from CD8 or CD16. We show, by expression of these chimeras in Ba/F3 or CTLL-2 cells, that mitogenic signals were only generated by heterodimerization of the cytoplasmic domains of IL-3 and βIL-3. Homodimers of either IL-3 or βIL-3, alone or in combination, were nonfunctional. Furthermore, the ability of heterodimers to stimulate mitogenesis correlated with their ability to induce tyrosine phosphorylation of JAK-2. These data suggest that the physiological activation of the IL-3R involves the generation of simple heterodimers of IL-3 and βIL-3.
Your time zone or mine? (2011)

We conducted interviews with sixteen members of teams that worked across global time zone differences. Despite time zone differences of about eight hours, collaborators still found time to synchronously meet. The interviews identified the diverse strategies teams used to find time windows to interact, which often included times outside of the normal workday and connecting from home to participate. Recent trends in increased work connectivity from home and blurred boundaries between work and home enabled more scheduling flexibility. While email use was understandably prevalent, there was also general interest in video, although obstacles remain for widespread usage. We propose several design implications for supporting this growing population of workers that need to span global time zone differences.
Enterobactin-Mediated Delivery of β-Lactam Antibiotics Enhances Antibacterial Activity against Pathogenic<i>Escherichia coli</i> (2014)

The design, synthesis, and characterization of enterobactin–antibiotic conjugates, hereafter Ent-Amp/Amx, where the β-lactam antibiotics ampicillin (Amp) and amoxicillin (Amx) are linked to a monofunctionalized enterobactin scaffold via a stable poly(ethylene glycol) linker are reported. Under conditions of iron limitation, these siderophore-modified antibiotics provide enhanced antibacterial activity against Escherichia coli strains, including uropathogenic E. coli CFT073 and UTI89, enterohemorrhagic E. coli O157:H7, and enterotoxigenic E. coli O78:H11, compared to the parent β-lactams. Studies with E. coli K-12 derivatives defective in ferric enterobactin transport reveal that the enhanced antibacterial activity observed for this strain requires the outer membrane ferric enterobactin transporter FepA. A remarkable 1000-fold decrease in minimum inhibitory concentration (MIC) value is observed for uropathogenic E. coli CFT073 relative to Amp/Amx, and time-kill kinetic studies demonstrate that Ent-Amp/Amx kill this strain more rapidly at 10-fold lower concentrations than the parent antibiotics. Moreover, Ent-Amp and Ent-Amx selectively kill E. coli CFT073 co-cultured with other bacterial species such as Staphylococcus aureus, and Ent-Amp exhibits low cytotoxicity against human T84 intestinal cells in both the apo and iron-bound forms. These studies demonstrate that the native enterobactin platform provides a means to effectively deliver antibacterial cargo across the outer membrane permeability barrier of Gram-negative pathogens utilizing enterobactin for iron acquisition.
Transgenic Reexpression of GLUT1 or GLUT2 in Pancreatic β Cells Rescues GLUT2-null Mice from Early Death and Restores Normal Glucose-stimulated Insulin Secretion (2000)

GLUT2-null mice are hyperglycemic, hypoinsulinemic, hyperglucagonemic, and glycosuric and die within the first 3 weeks of life. Their endocrine pancreas shows a loss of first phase glucose-stimulated insulin secretion (GSIS) and inverse alpha to beta cell ratio. Here we show that reexpression by transgenesis of either GLUT1 or GLUT2 in the pancreatic beta cells of these mice allowed mouse survival and breeding. The rescued mice had normal-fed glycemia but fasted hypoglycemia, glycosuria, and an elevated glucagon to insulin ratio. Glucose tolerance was, however, normal. In vivo, insulin secretion assessed following hyperglycemic clamps was normal. In vitro, islet perifusion studies revealed that first phase of insulin secretion was restored as well by GLUT1 or GLUT2, and this was accompanied by normalization of the glucose utilization rate. The ratio of pancreatic insulin to glucagon and volume densities of alpha to beta cells were, however, not corrected. These data demonstrate that 1) reexpression of GLUT1 or GLUT2 in beta cells is sufficient to rescue GLUT2-null mice from lethality, 2) GLUT1 as well as GLUT2 can restore normal GSIS, 3) restoration of GSIS does not correct the abnormal composition of the endocrine pancreas. Thus, normal GSIS does not depend on transporter affinity but on the rate of uptake at stimulatory glucose concentrations.
A DSP structure authorizing reduced-bandwidth DC/DC Converters for Dynamic Supply of RF Power Amplifiers in Wideband Applications (2006)

A most promising technique for the design of energy efficient Radio Frequency (RF) transmitters is based on modulating the supply of the main Power Amplifier (PA) by a DC/DC converter. However, the slow time-response of DC/DC converters compared to the large bandwidth of the RF signal to transmit is an obstacle for application to broadband communications. In this paper, a digital signal processing structure enabling the use of bandwidth-limited DC/DC converters, and resulting in linear, efficiency-enhanced transmitter behaviour is presented. Models of the PA and DC/DC converters are used to validate the principle through simulation procedures.
Observation of the skin-depth effect on the Casimir force between metallic surfaces (2005)

We have performed measurements of the Casimir force between a metallic plate and a transparent sphere coated with metallic films of different thicknesses. We have observed that, if the thickness of the coating is less than the skin-depth of the electromagnetic modes that mostly contribute to the interaction, the force is significantly smaller than that measured with a thick bulk-like film. Our results provide direct evidence of the skin-depth effect on the Casimir force between metallic surfaces.
The global burden of HIV-1 drug resistance in the past 20 years (2018)

Genotypic drug resistance testing has been an integral part of the clinical management of HIV patients for almost 20 years, not only assisting treatment choices but also informing drug development. Accurate estimations on the worldwide circulation of drug resistance are difficult to obtain, particularly in low/middle-income countries. In this work, we queried two of the largest public HIV sequence repositories in the world-Los Alamos and Stanford HIVdb-to derive global prevalence, time trends and geodemographic predictors of HIV drug resistance. Different genotypic interpretation systems were used to ascertain resistance to reverse transcriptase and protease inhibitors. Continental, subtype-specific (including circulating recombinant forms) stratification as well as analysis on drug-naïve isolates were performed. Geographic information system analysis correlated country-specific drug resistance to sociodemographic and health indicators obtained from the World Bank. By looking at over 33,000 sequences worldwide between 1996 and 2016, increasing drug resistance trends with non-B subtypes and recombinants were found; transmitted drug resistance appeared to remain stable in the last decade. While an increase in drug resistance is expected with antiretroviral therapy rollout in resource-constrained areas, the plateau effect in areas covered by the most modern drug regimens warns against the downgrading of the resistance issue.
Studies of compliance with delayed‐release mesalazine therapy in patients with inflammatory bowel disease (2003)

Non-compliance with maintenance mesalazine therapy is common in patients with inflammatory bowel disease. Three-times daily dosing and full-time employment are predictors of partial non-compliance, whilst depression is associated with complete non-compliance. Self-reporting detects most non-compliant patients.
Mobile IPv6 Fast Handovers for 802.11 Networks (2005)

This document describes how a Mobile IPv6 Fast Handover could be
implemented on link layers conforming to the 802.11 suite of
specifications. This memo provides information for the Internet
community.
Range image accuracy improvement by acquisition planning (1999)

The recent requirement for increased speed in the design and manufacturing of new products led to a rapid evolution of the technics for fast production (rapid prototyping, machining at high speed, etc.). But a significant component did not follow this evolution, that is the dimensional and functional checking process, which is most of the time carried out in a traditional way. The use of range sensor allows very significant improvement in acquisition speed but does not equal the accuracy obtained with a coordinate measuring machine. In order to obtain a quality control close to that obtained in metrology, we suggest to improve the accuracy of the depth measurements by following an acquisition strategy. We propose in this paper such a strategy to automatically produce a sensing plan for completely and precisely acquiring the geometry of a surface or of a complete piece whenever possible. The system requires the exact position and orientation of the part and its CAD model in IGES format. There is no limitation regarding the shape of the part to be digitized. A Biris sensor was used, and for this sensor, the precision of the 3D measured points is function of the distance and of the incident angle with which the laser beam reaches the surface. Our strategy guaranties that the viewpoint found meets the best precision conditions in the scanning process. 1
Modeling hierarchical microcell/macrocell PCS architecture (2002)

In a personal communications services (PCS) network, heavy traffic areas may be covered by microcells which overlay with macrocells. We propose an analytic model to study the performance of the microcell/macrocell PCS architecture. Our model assumes that a PCS subscriber has a general residual time distribution in a microcell, and the macrocell residual time distribution is derived based on the microcell residual time distribution. A five-step iterative algorithm is used to compute the overflow traffic from a microcell to its overlay macrocell. Then the call incompletion probability is computed by a macrocell model based on the overflow traffic. Our study indicates that the variance of the microcell residual time distribution and the number of microcells covered by a macrocell have significant effects on the call incompletion probability.
Handling query answering in crowdsourcing systems: A belief function-based approach (2016)

Crowdsourcing is defined as an emerging computation paradigm, where the power of crowds is utilized to facilitate large scale tasks that are costly or time consuming with traditional methods. One of the most important technical challenges of crowdsourcing is quality control of workers' responses. Human factors play a key role in achieving high quality answers in crowdsourcing-based solving tasks. The most major factor is pertained to the uncertainty of workers about the responses that they provide to resolve the task at hand. On the other hand, workers may have diverse levels of expertise and skill. It is then important to take into account both the degrees of uncertainty and expertise to return the most correct reliable answer. In this paper, we propose a belief functions-based approach to achieve this goal. We conduct also some comprehensive experiments to validate the effectiveness of our proposal.
Structure and Evolution of the Smith-Magenis Syndrome Repeat Gene Clusters, SMS-REPs (2002)

An approximately 4-Mb genomic segment on chromosome 17p11.2, commonly deleted in patients with the Smith-Magenis syndrome (SMS) and duplicated in patients with dup(17)(p11.2p11.2) syndrome, is flanked by large, complex low-copy repeats (LCRs), termed proximal and distal SMS-REP. A third copy, the middle SMS-REP, is located between them. SMS-REPs are believed to mediate nonallelic homologous recombination, resulting in both SMS deletions and reciprocal duplications. To delineate the genomic structure and evolutionary origin of SMS-REPs, we constructed a bacterial artificial chromosome/P1 artificial chromosome contig spanning the entire SMS region, including the SMS-REPs, determined its genomic sequence, and used fluorescence in situ hybridization to study the evolution of SMS-REP in several primate species. Our analysis shows that both the proximal SMS-REP (approximately 256 kb) and the distal copy (approximately 176 kb) are located in the same orientation and derived from a progenitor copy, whereas the middle SMS-REP (approximately 241 kb) is inverted and appears to have been derived from the proximal copy. The SMS-REP LCRs are highly homologous (>98%) and contain at least 14 genes/pseudogenes each. SMS-REPs are not present in mice and were duplicated after the divergence of New World monkeys from pre-monkeys approximately 40-65 million years ago. Our findings potentially explain why the vast majority of SMS deletions and dup(17)(p11.2p11.2) occur at proximal and distal SMS-REPs and further support previous observations that higher-order genomic architecture involving LCRs arose recently during primate speciation and may predispose the human genome to both meiotic and mitotic rearrangements.
The Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Prediction of Neural Risk for Alzheimer Disease (2011)

The BDNF gene confers risk in an age-dependent manner on the brain structures and cognitive functions that are consistent with the neural circuitry vulnerable in the earliest stages of AD. Our novel findings provide convergent evidence in vivo for a BDNF genetic mechanism of susceptibility in an intermediate phenotype related to AD.
Electron focusing in two-dimensional systems by means of an electrostatic lens (1990)

We introduce an electrostatic lens for ballistic electrons in two-dimensional (2D) systems and demonstrate its focusing action in very high mobility GaAs-(AlGa)As heterostructures. This is the first refractive element for the control of 2D electrons. It exemplifies the close analogy between ballistic propagation in 2D electron systems and traditional geometrical optics.
Generalized Multi-Protocol Label Switching (GMPLS) Extensions for Synchronous Optical Network (SONET) and Synchronous Digital Hierarchy (SDH) Control (2006)

This document is a companion to the Generalized Multi-Protocol Label
Switching (GMPLS) signaling. It defines the Synchronous Optical
Network (SONET)/Synchronous Digital Hierarchy (SDH) technology
specific information needed when using GMPLS signaling. [STANDARDS-
TRACK]
Antibodies to canine collagen types i and II in dogs with spontaneous cruciate ligament rupture and osteoarthritis (1987)

Antibodies to homologous collagens, types I and II, have been found in the sera and synovial fluids of dogs with spontaneous cruciate ligament rupture and osteoarthritis. Samples from 30 dogs with degenerative joint disease of the knee and from 15 healthy dogs were investigated by enzyme-linked immunosorbent assay. Fifty-three percent of dogs with joint disease showed significant levels of anti-type I collagen antibodies in their sera, and 56% had anti-type II reactivity. Ninety-one percent of the dogs with joint disease exhibited antibody reactivity to type I collagen in their synovial fluid, and 88% showed reactivity to type II collagen. Correlation of these results with the clinical data indicated that the antibodies had been elicited by antigens derived from cruciate ligaments (type I collagen) and from altered joint cartilage (type II collagen). Immunologic reactivity in this form of canine osteoarthritis is a new concept, and it should be considered in our attempts to understand the pathogenesis of this disease.
Un portrait en relief d'Aménophis II aux Musées royaux d'Art et d'Histoire (1970)

info:eu-repo/semantics/published
AIDS drug development, availability intensify (1989)

RECENT ACTIONS by federal health officials deliver on promises made in Montreal at the Fifth International Conference on Acquired Immunodeficiency Syndrome (AIDS) to speed up development, clinical trials, and availability of drugs to combat human immunodeficiency virus (HIV) disease. A month ago, the Food and Drug Administration (FDA) approved for marketing ganciclovir, produced by Syntex Corporation, Palo Alto, Calif, which is used to treat cytomegalovirus retinitis. The agency also gave the status of "investigational new drug for treatment"—thus allowing expanded premarket distribution—to recombinant human erythropoietin used to treat AIDS-associated anemia, produced by Ortho Pharmaceutical Corporation, Raritan, NJ. Ortho has announced that the company will provide the drug free during testing to patients who are anemic either as a result of HIV infection or because of the effects of taking zidovudine, or AZT. Two weeks earlier, the FDA approved for marketing aerosolized pentamidine (made by Lyphomed Inc, Rosemont, Ill) as prophylaxis
High performance liquid chromatography of proteins on a diol-bonded silica gel stationary phase (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh performance liquid chromatography of proteins on a diol-bonded silica gel stationary phaseDonald E. Schmidt, Roger W. Giese, Dana. Conron, and Barry L. KargerCite this: Anal. Chem. 1980, 52, 1, 177–182Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ac50051a040https://doi.org/10.1021/ac50051a040research-articleACS PublicationsRequest reuse permissionsArticle Views360Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of glycerol feeding on endurance and metabolism during prolonged exercise in man (1983)

This study evaluated the effectiveness of pre-exercise glycerol feeding in protecting against development of hypoglycemia and sparing muscle glycogen during prolonged, intense exercise. Thirty minutes after ingesting either glycerol (1 gm X kg-1 body weight) or a placebo, 10 cyclists performed as much exercise on a cycle ergometer as they were able in 150 min. The average exercise intensity was 72% of VO2max during both trials. Glycerol ingestion increased blood glycerol concentration 100-fold, but did not alter the respiratory exchange ratio (R), plasma levels of insulin and free-fatty acids, or blood lactate and beta-hydroxybutyrate. The only significant effect of glycerol feeding was to postpone the decline in blood glucose by about 30 min. This suggests that glycerol served, to a limited extent, as a gluconeogenic substrate; however, glycerol ingestion did not spare muscle glycogen during 90 min of treadmill exercise at 71% VO2max. It appears that man cannot utilize glycerol as gluconeogenic substrate rapidly enough to serve as a major energy source during strenuous exercise.
Hierarchical Intra Mode Decision for H.264/AVC (2010)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The intra mode prediction via exhaustive mode decision exploited in the H.264/advanced video coding effectively improves the coding efficiency, but at the expense of yielding higher computational complexity. In this letter, a fast intra mode decision algorithm, called the hierarchical intra mode decision (HIMD), is proposed to speed up the mode decision process by reducing the number of modes required to be checked for each macroblock. The novelty of the proposed HIMD algorithm lies at the following accounts. 1) An early decision with adaptive thresholding is developed for the mode decision of the luma component. 2) The candidate modes are selected according to their Hadamard distances and prediction directions. 3) Only one of the hierarchical paths will be chosen to compute its least rate-distortion cost. Experimental results have shown that the proposed HIMD algorithm achieves a reduction of 85.75% computational complexity on average, while incurring only 0.164 dB loss in peak signal-to-noise ratio (PSNR) and 2.336% increment on the total bit rate compared with that of exhaustive mode decision, which is a default approach set in the joint model reference software. </para>
Preparation of Small‐Molecule Microarrays by <i>trans</i>‐Cyclooctene Tetrazine Ligation and Their Application in the High‐Throughput Screening of Protein–Protein Interaction Inhibitors of Bromodomains (2013)

Fast and efficient: A library of trans-cyclooctene (TCO)-modified small molecules were immobilized on tetrazine-functionalized glass slides by using the fastest bioorthogonal reaction known. The resulting small-molecule microarray was screened against a variety of human bromodomains to identify protein–protein interaction inhibitors. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.