gebhart/patrepeval huggingface dataset:
The Physical Principles of Holography (1966)

Holography is a new form of recording images. By causing the light from the object to interfere with a reference beam a contour picture of the wave-surfaces from the object is recorded on a plate. When a coherent beam is passed through such o plate diffraction by the black-and-white fringes on the plate forms a virtual image of the original object which is identical with the original object in all three dimensions. The basic principles and technical requirements are described.
Asymmetric Real Time Scheduling on a Multimedia Processor (1998)

This paper describes the hardware and system software support for multi-tasking a dual-processor used in a multimedia system. One of the two processors is a conventional RISC processor, the other is a vector processor of new design. There is no commonality in the instruction sets of the two processors. We schedule the former preemptively and the latter cooperatively via check points, resulting in an asymmetric scheduling algorithm. Media processing requires predictable scheduling behaviors. Programmers can inform our scheduler of the Real Time requirements of their computations using time-constraints. Scheduling decisions are very fine-grained, and place strong efficiency demands on the system implementation. Introduction We have designed and implemented the system support for a new type of processor [Le96] , designed for a high performance multimedia architecture, code-named Talisman [To96]. This heterogeneous dualprocessor (MSP) contains a general purpose ARM RISC processor, a gener...
Role of thyroid hormone during early brain development (2004)

The present comments are restricted to the role of maternal thyroid hormone on early brain development, and are based mostly on information presently available for the human fetal brain. It emphasizes that maternal hypothyroxinemia - defined as thyroxine (T4) concentrations that are low for the stage of pregnancy - is potentially damaging for neurodevelopment of the fetus throughout pregnancy, but especially so before midgestation, as the mother is then the only source of T4 for the developing brain. Despite a highly efficient uterine-placental 'barrier' to their transfer, very small amounts of T4 and triiodothyronine (T3) of maternal origin are present in the fetal compartment by 4 weeks after conception, with T4 increasing steadily thereafter. A major proportion of T4 in fetal fluids is not protein-bound: the 'free' T4 (FT4) available to fetal tissues is determined by the maternal serum T4, and reaches concentrations known to be of biological significance in adults. Despite very low T3 and 'free' T3 (FT3) in fetal fluids, the T3 generated locally from T4 in the cerebral cortex reaches adult concentrations by midgestation, and is partly bound to its nuclear receptor. Experimental results in the rat strongly support the conclusion that thyroid hormone is already required for normal corticogenesis very early in pregnancy. The first trimester surge of maternal FT4 is proposed as a biologically relevant event controlled by the conceptus to ensure its developing cerebral cortex is provided with the necessary amounts of substrate for the local generation of adequate amounts of T3 for binding to its nuclear receptor. Women unable to increase their production of T4 early in pregnancy would constitute a population at risk for neurological disabilities in their children. As mild-moderate iodine deficiency is still the most widespread cause of maternal hypothyroxinemia in Western societies, the birth of many children with learning disabilities may already be preventable by advising women to take iodine supplements as soon as pregnancy starts, or earlier if possible.
Image gathering and processing: information and fidelity (1985)

In this paper we formulate and use information and fidelity criteria to assess image gathering and processing, combining optical design with image-forming and edge-detection algorithms. The optical design of the image-gathering system revolves around the relationship among sampling passband, spatial response, and signal-to-noise ratio (SNR). Our formulations of information, fidelity, and optimal (Wiener) restoration account for the insufficient sampling (i.e., aliasing) common in image gathering as well as for the blurring and noise that conventional formulations account for. Performance analyses and simulations for ordinary optical-design constraints and random scenes indicate that (1) different image-forming algorithms prefer different optical designs; (2) informationally optimized designs maximize the robustness of optimal image restorations and lead to the highest-spatial-frequency channel (relative to the sampling passband) for which edge detection is reliable (if the SNR is sufficiently high); and (3) combining the informationally optimized design with a 3 by 3 lateral-inhibitory image-plane-processing algorithm leads to a spatial-response shape that approximates the optimal edge-detection response of (Marr's model of) human vision and thus reduces the data preprocessing and transmission required for machine vision.
Multi‐Functional Electronics: Multifunctional Epidermal Electronics Printed Directly Onto the Skin (Adv. Mater. 20/2013) (2013)

Health-monitoring devices that can be mounted onto the human skin are of great medical interest. On page 2773, John A. Rogers and co-workers present materials and designs for electronics and sensors that can be conformally and robustly integrated onto the surface of the skin. This image shows an epidermal electronic system of serpentine traces that is directly printed onto the skin with conformal lamination.
Antithrombin I. Inhibition of thrombin generation in plasma by fibrin formation (2003)

Thrombin substrate binding is mediated through fibrinogen recognition "exosite 1" in thrombin, resulting in fibrinopeptide cleavage to form fibrin. In addition, thrombin exhibits "non-substrate" binding to fibrin, an activity termed "Antithrombin I". Antithrombin I (AT-I) is characterized by two classes of thrombin binding sites, the first of "low affinity" in the fibrin E domain, and the other of high affinity, that is situated between C-terminal residues 414 and 427 of a variant gamma chain termed gamma'(1-427L), Plasma fibrinogen molecules containing gamma' chains ("fibrinogen 2") are virtually all heterodimers containing one gamma(A) chain (platelet-binding) and one gamma' chain. The remaining fibrinogen (approximately 85%) is homodimeric, lacks high affinity thrombin-binding potential, and is termed " fibrinogen 1" (gamma(A)/gamma(A)). Thrombin generation in recalcified fibrinogen-depleted or congenital afibrinogenemic plasma is increased. Repletion with fibrinogen 1 has a modest effect in normalizing thrombin generation, whereas repletion with fibrinogen 2 (gamma(A)/gamma') has a more marked effect. A post-translational gamma' chain derivative, gamma'(1-423P), accounts for 3%-34% of the gamma' chain population, lacks thrombin binding potential, and arises by proteolytic processing at the expense of gamma' (1-427L) chains. Little is known about its effect on plasma AT-I activity under normal or pathological circumstances. In summary, fibrin formation (Antithrombin I) inhibits thrombin generation in clotting blood by sequestering thrombin, and "high-affinity" thrombin-binding (i.e., via gamma' chains) plays a dominant role in this process. AT-1 should be considered when assessing the pathogenesis of thromboembolic disease.
Pyrolysis mass spectrometry in epidemiological and population genetic studies of Haemophilus influenzae (1997)

Haemophilus influenzae serotype b (Hib) vaccines have reduced the amount of invasive Hib disease in immunised infants. However, Hib disease remains in unvaccinated infants and adults and non-capsulate H. influenzae (NCHi) still causes infections, including outbreaks of respiratory disease. Characterisation of strains and the bacterial population as a whole is therefore necessary to detect outbreaks of infection with NCHi or changes in the population, for example, to vaccine-resistant clones of Hib. The rapid, simple and objective technique of pyrolysis mass spectrometry (PMS) was investigated as an alternative to current complex, subjective methods. PMS was compared with ribotyping and multilocus enzyme electrophoresis (MLEE) for population genetic analyses of Hib and with ribotyping and protein profiling for epidemiological analyses of NCHi. PMS clustered all the isolates of Hib together whereas MLEE and ribotyping distinguished certain clones - this is probably because the three methods examine different (and unrelated) characteristics of the organisms. The PMS results were essentially similar to those from ribotyping and protein profiling for the epidemiological analyses of outbreaks of NCHi disease. Therefore, PMS is probably unsuitable for comparisons of Hib populations but it is a useful addition to the arsenal of techniques for the characterisation of NCHi.
Understanding the correlation of TXRF and surface SIMS (2002)

The measurement of the surface metal contamination on silicon wafers is an essential part of yield improvement during IC processing. Total reflection X-ray fluorescence (TXEF) and secondary ion mass spectrometry (SIMS) are widely used analytical tools to monitor contamination on semiconductor wafers. A comparison of SurfaceSIMS measurements of surface metal contamination on silicon wafers with TXRF analyses of the same wafers is presented. These two important surface analysis techniques are characterized by differing analytical areas and sampling depths. For Fe, agreement between SurfaceSIMS and TXRF results is good (generally within a factor of two) for silicon wafers from a variety of sources with contamination levels ranging from 8/spl times/10/sup 9/ to 2/spl times/10/sup 15/ atoms/cm/sup 2/. Differences between SurfaceSIMS and TXRF results occur for other elements (such as W and Cu) when the contamination is not uniform across the surface of the wafer (particles are present), or extends a significant depth below the surface of the wafer (as is frequently the case for ion-implanted wafers),.
High power terahertz emission from a single gate AlGaN/GaN field effect transistor with periodic Ohmic contacts for plasmon coupling (2010)

We report on room temperature terahertz (THz) emission by a single, short gate AlGaN/GaN field effect transistor with grating Ohmic contacts. The fingers of metal contacts are fabricated at the nanoscale in length and spacing in order to work as a radiation coupler of electron plasmons in the THz range. Spectrum analysis revealed a broadband emission centered at 1.5 THz with a controlled polarization by the grating contacts. The measured output power is linearly increased with the drain input power and reached up to 1.8 μW.
MicroRNA-204 critically regulates carcinogenesis in malignant peripheral nerve sheath tumors (2012)

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft tissue sarcomas accounting for 3%-10% of all soft tissue sarcomas. Neurofibromatosis type 1 (NF1) is the most important known risk factor. MPNSTs are often diagnosed at an advanced stage when distant metastases have developed. Although surgical resection remains the main treatment for MPNSTs, complete surgical resection is rarely possible. The prognosis for patients with MPNSTs is poor. There is an urgent need for improved therapies. To this end, we investigated whether microRNA (miR), specifically miR-204, might be implicated in MPNSTs because it is located at a cancer-associated genomic region exhibiting high frequency of loss of heterozygosity in tumors. We show that miR-204 expression is downregulated in NF1 and non-NF1 MPNST tumor tissues and in tumor cell lines. Restoring miR-204 expression in MPNST cell lines STS26T (non-NF1), ST88-14 (NF1), and T265p21 (NF1) significantly reduces cellular proliferation, migration, and invasion in vitro. Restoring miR-204 expression in STS26T decreases tumor growth and malignant progression in vivo. We also report that miR-204 inhibits Ras signaling and expression of high mobility group gene A2. These findings support the hypothesis that miR-204 plays critical roles in MPNST development and tumor progression. miR-204 may represent a novel biomarker for diagnosis and a candidate target with which to develop effective therapies for MPNSTs.
Interfacial bonding and optical transmission for transparent fiberglass/poly(methyl methacrylate) composites (1995)

Abstract Evidence is presented relating the interfacial bonding strength and the optical transmission of transparent glass fiber reinforced PMMA composites. The temperature dependent (20° to 50°C) optical transmission of composites that contained uncoated 13 μm glass fibers and 13 μm glass fibers coated with divinyltetramethyl disilazane or 3‐(trimethoxysilyl)propyl methacrylate was found to decrease in the same order as the bond strength of the PMMA/glass fiber interface, namely, trimethoxy silane coated fiber, disilazane coated fiber, and uncoated fiber. SEM photographs showed similar fracture surfaces, clean fiber pull‐out, and no apparent bonding of the glass fiber to the PMMA for the composites containing uncoated and disilazane coated fiber, whereas, the composite containing trimethoxy silane coated fiber showed virtually no clean fiber pullout. Additional evidence for differences in the bonding strength is seen in the degradation (penetration of water and fiber whitening) on aging at 23°C in air or water for composites containing uncoated fiber (most degradation), disilazane coated fiber (slight degradation), and trimethoxy silane coated fiber (no degradation). The optical transmission between 20° and 30°C at 600 to 800 nm for the composite containing trimethoxy silane coated fiber decreased the least with increasing temperature (from ∼85% to 70%) while the composite containing uncoated fiber decreased the most (from ∼85% to 32%).
A new yellow-seeded canola genotype originating from double low black-seeded <i>Brassica napus</i> cultivars (2005)

A new source of yellow-seeded Brassica napus canola has been identified in doubled haploid progeny, from a cross between the two black-seeded spring cultivars, Star and Bolero. Six yellow-seeded doubled haploid lines were extracted from the F 1 generation of this cross. The yellow-seeded doubled haploid lines and some of their progeny showed differences in yellow seed colour expression in different temperature environments, among the 11 lines investigated. Similar populations of plants grown in daily maximum temperatures of 20, 28 and over 30°C showed increasing seed yellowness in the hot temperature and were darker in colour in the cool environments. Oil quality and fatty acid profiles were compared between yellow and dark seeded pairs. Although percent oil showed no overall trend in direction of change, oleic acid increased on average by 10%, while linolenic acid decreased by 5% under warmer growing conditions. Glucosinolate levels were stable between the yellow-seeded and dark-seeded pairs grown in either hot or cool temperatures. The yellow-seeded inbreds retained canola quality. Preliminary inheritance ratios suggest that this trait might be governed by fewer than three genes, and PCR analysis indicates that different genes may be involved here than those for the yellow-seeded genotypes previously published, which were derived from interspecific crosses. Key words: Brassica napus, yellow seed, temperature, oil quality
Improved customer choice predictions using ensemble methods (2005)

In this paper various ensemble learning methods from machine learning and statistics are considered and applied to the customer choice modeling problem. The application of ensemble learning usually improves the prediction quality of flexible models like decision trees and thus leads to improved predictions. We give experimental results for two real-life marketing datasets using decision trees, ensemble versions of decision trees and the logistic regression model, which is a standard approach for this problem. The ensemble models are found to improve upon individual decision trees and outperform logistic regression. Next, an additive decomposition of the prediction error of a model, the bias/variance decomposition, is considered. A model with a high bias lacks the flexibility to fit the data well. A high variance indicates that a model is instable with respect to different datasets. Decision trees have a high variance component and a low bias component in the prediction error, whereas logistic regression has a high bias component and a low variance component. It is shown that ensemble methods aim at minimizing the variance component in the prediction error while leaving the bias component unaltered. Bias/variance decompositions for all models for both customer choice datasets are given to illustrate these concepts.
Offset Quadrature Communications with Decision-Feedback Carrier Synchronization (1974)

In this paper, we focus our attention on the decisionfeedback approach to carrier synchronization of offset quadrature phase-shift-keyed (QPSK) and more generally offset quadrature amplitude-shift-keyed (QASK) systems. In particular, we present two decision-feedback loops for tracking offset QPSK and offset QASK, which are modifications of comparable loops previously given in the literature for carrier synchronization of QPSK and QASK respectively. The performance gains obtained using such synchronization techniques are discussed. In particular, we show that the use of offset-quadrature communications rather than conventional quadrature communications permits a doubled loop bandwidth at fixed data rate, signal-to-noise ratio and probability of error. However, the more efficient phase-tracking loop (decision-feedback as opposed to phase-locked loop) used reduces substantially the total signal-to-noise ratio required.
A fully adaptive transversal canceler and equalizer chip (1983)

A wide dynamic range (84dB) analog sampled-data transversal filter circuit will be described. The chip in CMOS technology is 34mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and includes all timing, control and memory circuits for both a 24th-order adaptive canceler and a user-programmable eighth-order gain/slope equalizer.
Effect of Thermal Treatment on the Electrocatalytic Activities and Surface Roughness of ITO Electrodes (2012)

The electrocatalytic activities and surface roughness of indium-tin-oxide (ITO) electrodes have been investigated after thermal treatment at 100, 150, or 200 o C for 30 min, 2 h, or 8 h. To check electrocatalytic activities, the electrochemical behavior of four electroactive species ( p-hydroquinone, Ru(NH 3 ) 6
Heck Couplings at Room Temperature in Nanometer Aqueous Micelles (2008)

A nonionic amphiphile such as Triton X-100 or the vitamin E-based PTS, both of which form nanomicelles in water, promotes Heck cross-couplings of non-water-soluble partners at ambient temperatures. These are the first examples of Heck reactions conducted in water (as the only solvent) at room temperature.
The molecular genetics of cardiovascular disease (1995)

The following consideration of this past year's published studies uses the cited reports as important examples of the ongoing characterization of the molecular basis of cardiac disease and the process of cardiac development. Mutations in cardiac troponin T and alpha-tropomyosin have been identified in familial hypertrophic cardiomyopathy, as have new beta-myosin heavy chain gene mutations. The general relation between beta-myosin heavy chain gene mutations that produce a charge change versus conservative amino acid replacements and sudden death remains unresolved. New fibrillin 1 gene mutations have been identified in patients with Marfan syndrome, the neonatal form of Marfan syndrome, and ectopia lentis. The same mutation is rarely found in more than one family. The association of supravalvar aortic stenosis and elastin gene mutations was further strengthened. The complexity of the relation between dystrophin mutations and the cell-specific loss of dystrophin expression can result in patients having cardiomyopathy and no myopathy. X-chromosome inactivation was shown to be the basis of cardiomyopathy in women with a single mutated dystrophin allele. New candidate genes that control cardiac morphogenesis and myocyte differentiation were proposed. New evidence to support 22q11 microdeletions as a common basis of nonsyndromic conotruncal malformations was published. These studies represent an important beginning. Although mutant genes have been recognized in affected individuals with various syndromes and congenital cardiac abnormalities, our understanding of how a genotype yields a given phenotype remains to be established.
Inflammation-Induced Acid Tolerance Genes <i>gadAB</i> in Luminal Commensal Escherichia coli Attenuate Experimental Colitis (2013)

Dysregulated immune responses to commensal intestinal bacteria, including Escherichia coli, contribute to the development of inflammatory bowel diseases (IBDs) and experimental colitis. Reciprocally, E. coli responds to chronic intestinal inflammation by upregulating expression of stress response genes, including gadA and gadB. GadAB encode glutamate decarboxylase and protect E. coli from the toxic effects of low pH and fermentation acids, factors present in the intestinal lumen in patients with active IBDs. We hypothesized that E. coli upregulates gadAB during inflammation to enhance its survival and virulence. Using real-time PCR, we determined gadAB expression in luminal E. coli from ex-germfree wild-type (WT) and interleukin-10 (IL-10) knockout (KO) (IL-10(-/-)) mice selectively colonized with a commensal E. coli isolate (NC101) that causes colitis in KO mice in isolation or in combination with 7 other commensal intestinal bacterial strains. E. coli survival and host inflammatory responses were measured in WT and KO mice colonized with NC101 or a mutant lacking the gadAB genes (NC101ΔgadAB). The susceptibility of NC101 and NC101ΔgadAB to killing by host antimicrobial peptides and their translocation across intestinal epithelial cells were evaluated using bacterial killing assays and transwell experiments, respectively. We show that expression of gadAB in luminal E. coli increases proportionately with intestinal inflammation in KO mice and enhances the susceptibility of NC101 to killing by the host antimicrobial peptide cryptdin-4 but decreases bacterial transmigration across intestinal epithelial cells, colonic inflammation, and mucosal immune responses. Chronic intestinal inflammation upregulates acid tolerance pathways in commensal E. coli isolates, which, contrary to our original hypothesis, limits their survival and colitogenic potential. Further investigation of microbial adaptation to immune-mediated inflammation may provide novel insights into the pathogenesis and treatment of IBDs.
A Vapor-Phase Deposited Polymer Film to Improve the Adhesion of Electroless-Deposited Copper Layer onto Various Kinds of Substrates (2014)

The adhesion of electrodeposited metal film to polymeric circuit board substrate is one of the key elements to successful miniaturization of electronic devices. However, as the size of the circuit pattern continuously decreases, a novel method is urgently required to increase the adhesion of the metal film on the substrate, especially on the smooth surface, which is critical to decrease the minimum feature size of the metal pattern. In this research, we developed an adhesion promoter layer by depositing metal chelating poly(4-vinylpyridine) (P4VP) film onto various organic and inorganic substrates via initiated chemical vapor deposition process (iCVD) to enhance the adhesion between the electroless deposited copper (Cu) layer and the substrate. The highest peel strength obtained between the electroless deposited Cu layer and P4VP coated substrate was 1.22 kgf/cm. Many advantageous characteristics of the adhesion promoter layer, including extreme thinness, the improved adhesion strength, conformal coverage, scalability of the deposition process, and short process time, will prompt the applicability of this adhesion promoter layer to industrial scale production.