gebhart/patrepeval huggingface dataset:
Fate of Volatile Organic Compounds and Pesticides In Composted Municipal Solid Waste (1997)

Composting of municipal solid waste (MSW) has many advantages including volume reduction, reduced atmospheric emissions of methane from landfills, and the potential for beneficial use of the end product. Information about the fate of volatile organic chemicals (VOCs) which are commonly present in MSW is needed to protect the environment from undesirable emissions. To achieve this goal, the present study was undertaken to evaluate the fate of four VOCs (benzene, carbon tetrachloride, dichlorobenzene, and xylene) and two pesticides (Captan and Lindane) added to simulated MSW. Volatile organic chemicals were added at three concentrations while pesticides were tested at a single concentration. All of the treatments were replicated three times and composted in 200 L aerated static pile composters. The composters were specially equipped with pumps and flow meters to aerate the feedstock at 1.12-1.68 m3/hr, sorption filters to collect volatile organic chemicals from the exiting air stream, and leachate collection vessels. The feedstock was selected to be representative of MSW after the majority of recyclable metal and glass had been removed and was spiked with organic chemicals known to commonly occur in MSW.The results showed that the majority of VOCs present in the feedstock were lost via volatilization in the initial 48 hours of composting. Concentrations of VOCs were below detection limits after one week of composting in both the leachate and compost. Thus, while aerated pile composting is effective in removing VOCs from the feedstock, the exiting air stream will need to be monitored for approximately one week and possibly treated to meet environmental quality standards.Aerobic composting reduced the initial concentrations of 275 mg/kg each of Captan and Lindane to final concentrations of 53.8 and 158.9 mg/kg, respectively, after five weeks of composting. This corresponded to half lives of 1.5 and four weeks during composting for Captan and Lindane respectively. All concentrations of both pesticides were below detection limits in all samples of air, condensate and leachate, in dicating that none of the pesticides were volatilized and all were retained by the MSW until they biodegraded.
Path Relaxation: Path Planning for a Mobile Robot (1984)

Path Relaxation is a method of planning safe paths around obstacles for mobile robots. It works in two steps: a global grid search that finds a rough path, followed by a local relaxation step that adjusts each node on the path to lower the overall path cost. The representation used by Path Relaxation allows an explicit tradeoff among length of path, clearance away from obstacles, and distance traveled through unmapped areas.
Modulation of A beta adhesiveness and secretase site cleavage by zinc. (1994)

Abnormalities of zinc homeostasis occur in Alzheimer's disease (AD), a dementia characterized by the aggregation of A beta in the brain, and in Down syndrome, a condition characterized by premature AD. We studied the binding of Zn2+ to a synthetic peptide representing residues 1-40 (A beta 1-40), as well as other domains of A beta. Two classes of Zn2+ binding were identified by 65Zn2+ labeling: highly specific pH-dependent high affinity (K(a) = 107 nM) binding, and lower affinity (K(a) = 5.2 microM) binding. Gel filtration chromatography identified monomeric, dimeric, and polymeric A beta species. Zinc induced a marked loss of A beta solubility upon chromatographic analysis. This was attributed to precipitation onto the column glass, which contains aluminosilicate, and was confirmed by the observation of zinc-accelerated precipitation of A beta by kaolin, a hydrated aluminum silicate suspension. Zinc binding also increased A beta resistance to tryptic cleavage at the secretase site, indicating that a small (<3 microM) increase in brain Zn2+ concentration could significantly alter A beta metabolism. We propose that elevated brain interstitial zinc levels may increase A beta adhesiveness and interfere with A beta catabolism. Consequently, abnormalities of regional zinc concentrations in the brains of patients with AD or Down syndrome may contribute to A beta amyloidosis in these disorders.
Reduced white fat mass in adult mice bearing a truncated Patched 1 (2008)

Hedgehog (Hh) signaling emerges as a potential pathway contributing to fat formation during postnatal development. In this report, we found that Patched 1 (Ptc1), a negative regulator of Hh signaling, was expressed in the epididymal fat pad of adult mice. Reduced total white fat mass and epididymal adipocyte cell size were observed in naturally occurring spontaneous mesenchymal dysplasia (mes) adult mice (Ptc1(mes/mes)), which carry a deletion of Ptc1 at the carboxyl-terminal cytoplasmic region. Increased expression of truncated Ptc1, Ptc2 and Gli1, the indicators of ectopic activation of Hh signaling, was observed in epididymal fat pads of adult Ptc1(mes/mes) mice. In contrast, expression of peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein alpha, adipocyte P2 and adipsin were reduced in epididymal fat pads of adult Ptc1(mes/mes) mice. Taken together, our results indicate that deletion of carboxyl-terminal tail of Ptc1 can lead to the reduction of white fat mass during postnatal development.
Determinants of human myelin basic protein that induce encephalitogenic T cells in Lewis rats. (1989)

Due to critical amino acid changes in the 72-89 sequence, the determinant of human (Hu) basic protein (BP) that induces experimental autoimmune encephalomyelitis (EAE) in Lewis rats most likely differs from rat and guinea pig BP. To discern encephalitogenic sequence(s), the immunodominant epitopes recognized by Hu-BP-specific T cell lines were identified using synthetic peptides that corresponded to the Hu-BP sequence. The Hu-BP-reactive T cell line contained two distinct specificities, one directed at the 87-99 (Hu) sequence restricted by I-E, and the second directed at the 55-74 (Hu) sequence restricted by I-A. T cells specific for the 87-99 determinant recognized both Hu- and Rt-BP, were highly encephalitogenic, and accounted for the experimental autoimmune encephalomyelitis-inducing activity of the Hu-BP line. T cells directed at the S55-74 (Hu) sequence did not recognize Rt-BP and were not encephalitogenic. The same TCR V genes (homologous to the mouse V alpha 2 and V beta 8 families) that we showed previously were utilized preferentially in response to the I-A restricted 72-89 encephalitogenic sequence were also present in T cell lines specific for both the S55-74 and S87-99 epitopes. These data indicate that encephalitogenic activity of BP in Lewis rats is related to discrete T cell epitopes that are present on or cross-react with rat-BP. Furthermore it would appear that genes in the TCR V alpha 2 and V beta 8 families are widely used in response to different BP epitopes restricted by either I-A or I-E molecules.
Design and implementation of a bootstrap trust chain (2006)

The chain of trust in bootstrap process is the basis of whole system trust in the trusted computing group (TCG) definition. This paper presents a design and implementation of a bootstrap trust chain in PC based on the Windows and today's commodity hardware, merely depends on availability of an embedded security module (ESM). ESM and security enhanced BIOS is the root of trust, PMBR (Pre-MBR) checks the integrity of boot data and Windows kernel, which is a checking agent stored in ESM. In the end, the paper analyzed the mathematic expression of the chain of trust and the runtime performance compared with the common booting process. The trust chain bootstrap greatly strengthens the security of personal computer system, and affects the runtime performance with only adding about 12% booting time.
Putative pheromone receptors related to the Ca <sup>2+</sup> -sensing receptor in <i>Fugu</i> (1998)

By a combination of PCR with degenerate primers and low stringency probing, we have isolated a large family of genes related to the Ca2+-sensing receptor from the genome of Fugu rubripes. One of the genes (type I) is the Fugu homologue of the Ca2+-sensing receptor. The remaining genes can be divided into five classes (type II-VI) on the bases of gene structure. In several types, the genes occur in clusters as tandem arrays. These genes appear to be the homologues of the vomeronasal pheromone receptors recently described in rodents. The Fugu genes are expressed in the tissues of the nose, suggesting that they may have a similar physiological role.
A broadly tuned mouse odorant receptor that detects nitrotoluenes (2012)

Mammals employ large numbers of odorant receptors to sample and identify volatile chemicals in the environment. These receptors are thought to vary not only in specificity for particular odorants, but also in breadth of tuning. That is, some odorant receptors are narrowly focused on a few closely related structures, while other odorant receptors may be 'broadly tuned', responding to a wide variety of odorant structures. In this study, we have performed a detailed examination the mouse odorant receptor MOR256-17, demonstrating that this receptor is broadly tuned. This receptor responds to odorant structures that span a significant portion of a multi-dimensional odor space. However, we found that broad tuning was not a defining characteristic of other members the MOR256 subfamily. Two additional members of this odorant receptor subfamily (MOR256-8 and MOR256-22) were more narrowly focused on small sets of odorant structures. Interestingly, the receptive range of MOR256-17 encompassed a variety of nitrotoluenes, including various trinitrotoluene synthesis intermediates, degradation products and trinitrotoluene itself, suggesting the potential utility of odorant receptors in the development of sensing technologies for the detection of explosives and other forms of contraband.
Two-Level QR Code for Private Message Sharing and Document Authentication (2015)

The quick response (QR) code was designed for storage information and high-speed reading applications. In this paper, we present a new rich QR code that has two storage levels and can be used for document authentication. This new rich QR code, named two-level QR code, has public and private storage levels. The public level is the same as the standard QR code storage level; therefore, it is readable by any classical QR code application. The private level is constructed by replacing the black modules by specific textured patterns. It consists of information encoded using q-ary code with an error correction capacity. This allows us not only to increase the storage capacity of the QR code, but also to distinguish the original document from a copy. This authentication is due to the sensitivity of the used patterns to the print-and-scan (P&S) process. The pattern recognition method that we use to read the second-level information can be used both in a private message sharing and in an authentication scenario. It is based on maximizing the correlation values between P&S degraded patterns and reference patterns. The storage capacity can be significantly improved by increasing the code alphabet q or by increasing the textured pattern size. The experimental results show a perfect restoration of private information. It also highlights the possibility of using this new rich QR code for document authentication.
Humans Have Antibodies against a Plant Virus: Evidence from Tobacco Mosaic Virus (2013)

Tobacco mosaic virus (TMV), a widespread plant pathogen, is found in tobacco (including cigarettes and smokeless tobacco) as well as in many other plants. Plant viruses do not replicate or cause infection in humans or other mammals. This study was done to determine whether exposure to tobacco products induces an immune response to TMV in humans. Using a sandwich ELISA assay, we detected serum anti-TMV antibodies (IgG, IgG1, IgG3, IgG4, IgA, and IgM) in all subjects enrolled in the study (20 healthy smokers, 20 smokeless-tobacco users, and 20 non-smokers). Smokers had a higher level of serum anti-TMV IgG antibodies than non-smokers, while the serum level of anti-TMV IgA from smokeless tobacco users was lower than smokers and non-smokers. Using bioinformatics, we also found that the human protein TOMM40L (an outer mitochondrial membrane 40 homolog -like translocase) contains a strong homology of six contiguous amino acids to the TMV coat protein, and TOMM40L peptide exhibited cross-reactivity with anti-TMV antibodies. People who smoke cigarettes or other tobacco products experience a lower risk of developing Parkinson's disease, but the mechanism by which this occurs is unclear. Our results showing molecular mimicry between TMV and human TOMM40L raise the question as to whether TMV has a potential role in smokers against Parkinson's disease development. The potential mechanisms of molecular mimicry between plant viruses and human disease should be further explored.
Expression of cytokeratin 19 in human hepatocellular carcinoma cell lines (2002)

It has been reported that the cytokeratin 19 (CK19) fragment, CYFRA 21-1, is increased in sera of some hepatocellular carcinoma patients. We hypothesized that CYFRA 21-1 might be released directly from hepatocellular carcinoma. To investigate this mechanism, we evaluated expression of CK19 in 8 human cell lines by immunoradiometric assay, Western blotting, immunohistochemistry, and reverse transcriptase-polymerase chain reaction in Chang liver cells, 2 cholangiocarcinoma cell lines, and 5 hepatocellular carcinoma cell lines. Three of 5 hepatocellular carcinoma cell lines released CYFRA 21-1, synthesized CK19 protein and expressed mRNA for CK19, as observed in 2 cholangiocarcinoma cell lines. In contrast, there was no expression of CK19 in Chang liver cells or 2 of 5 hepatocellular carcinoma cell lines. Analysis of genomic DNA for CK19 demonstrated that exon 1 was not amplified in the 3 cell lines not expressing CK19. However, there were no point mutations within exon 1 and the promoter region of CK19 in hepatocellular carcinoma cell lines. Our present study demonstrates that: i) the expression of CK19 was evident in some human hepatocellular carcinoma cell lines, and ii) the expression of mRNA for CK19 was related to the release of CYFRA 21-1. These results partially clarify the mechanism by which some hepatocellular carcinoma cell lines produce CK19 and others do not.
Adaptive Quad Mesh Simplification (2010)

We present an improved algorithm for the progressive simplification of quad meshes, which adapts the resolution of the mesh to details of the modeled shape. We extend previous work [TPC*10], by simplifying the approach and combining it with the concept of Fitmaps introduced in [PPT*10]. The new algorithm has several advantages: it is simpler and more robust; it does not need a parametrization of the input shape; it is adaptive; and it preserves projectability of the output mesh to the input shape, thus supporting displacement mapping. We present experimental results on a variety of datasets, showing relevant improvement over previous results under several aspects.
Current Targeted Therapies in HER2-Positive Gastric Adenocarcinoma (2017)

Gastric cancer is one of the most common types of cancer in the world, usually diagnosed at an advanced stage. Despite the advances in specific anticancer agents' development, the survival rates remain modest, even in early stages. In 15%-20% of cases, the human epidermal growth factor receptor 2 (HER2) overexpression was identified. We conducted a general review to summarize the progress that has been made in the targeted treatment of HER2-positive esogastric junction or gastric adenocarcinoma. According to our findings, trastuzumab is the only validated anti-HER2 agent in locally advanced or metastatic disease and its adjuvant effectiveness is assessed in a RTOG phase III study. In a previously treated advanced disease, the maytansine derivate TDM 1 failed to be approved as a second-line regimen, and the tyrosine kinase inhibitor, lapatinib, shows modest results. The antiangiogenics have not been analyzed in specific populations and targeting the mesenchymal-epithelial transition factor (MET) receptor, overexpressed in up to 46% of the advanced disease, seems encouraging. Regarding the checkpoint inhibitors, based on KEYNOTE 059 multilevel ongoing trial, stratified according to the HER2 and programmed death-ligand (PD-L) 1 status, pembrolizumab was approved for third-line treatment of gastric or gastroesophageal junction adenocarcinoma.
Augmented reality flavors (2011)

The main contribution of this paper is to realize computer generated augmented flavors and establish a method to integrate gustatory information into computer human interactions. There are several reasons for the scarcity of research on gustatory information. One reason is that taste sensations are affected by a number of factors, such as vision, olfaction and memories. This produces a complex cognition mechanism for a user's gustatory sensation, and makes it difficult to build up a gustatory display which produces a specific taste on demand.
Statistical analysis of insertion-loss improvement for optical connectors using the orientation method for fiber-core offset (1991)

Improvements in the insertion loss of optical connectors by the orientation technique, in which a fiber-core offset is aligned with the key direction of a connector, are analyzed quantitatively. A statistical distribution of insertion losses is derived from the probability theory. Excellent agreement is demonstrated between the theory and the experimental results using single-mode fiber connectors. The result shows that the orientation technique can improve the percentage of insertion losses not exceeding 0.5 dB to 99.7% from 86.5% for random concatenation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Piezo-induced sensitivity enhancements in electro-optic field sensors (2005)

Responsivity measurements are reported for LiNbO3 electro-optic field sensors operated under applied electric fields at ac frequencies in the vicinity of the acoustic resonance values of the crystals. At these frequencies, piezoelectric effects dominate the sensor output. These resonance effects are well known and commonly considered parasitic. However, we propose their use as a sensitivity-enhancing mechanism for electric-field detection. We have found that our field sensors operated within these resonances responded linearly with the applied field strength and exhibited increases in their intrinsic sensitivities as high as 350 times larger than their normal, electro-optic values. Our modeling of the data suggests that the sensitivity enhancements are produced by the interplay between photoelastic shifts in the refractive indices and the physical vibration modes of the crystals. Aside from narrowband applications, these resonant enhancements can be exploited with fields at frequencies well beyond the narrow bandwidth of the acoustic resonance, if the fields are properly modulated.
Materials development and potential applications of transparent ceramics: A review (2019)

Transparent ceramics have various potential applications such as infrared (IR) windows/domes, lamp envelopes, opto-electric components/devices, composite armors, and screens for smartphones and they can be used as host materials for solid-state lasers. Transparent ceramics were initially developed to replace single crystals because of their simple processing route, variability in composition, high yield productivity, and shape control, among other factors. Optical transparency is one of the most important properties of transparent ceramics. In order to achieve transparency, ceramics must have highly symmetric crystal structures; therefore, the majority of the transparent ceramics have cubic structures, while tetragonal and hexagonal structures have also been reported in the open literature. Moreover, the optical transparency of ceramics is determined by their purity and density; the production of high-purity ceramics requires high-purity starting materials, and the production of high-density ceramics requires sophisticated sintering techniques and optimized sintering aids. Furthermore, specific mechanical properties are required for some applications, such as window materials and composite armor. This review aims to summarize recent progress in the fabrication and application of various transparent ceramics.
[The antibacterial action of new hydrazide derivatives]. (1994)

New derivatives of 4-aminobenzoic and 4-chlorine-2-hydroxybenzoic acids hydrazides were synthesized by the condensation reaction of these hydrazides with aldehydes and ketones, derivatives containing in their molecule azometine and hydrazone groups. The obtained products are potentially bioactive. The study of their "in vitro" biological activity was performed on some pathogenic germs, both gram-positive and gram-negative. The results show that the tested substances are more active towards the gram-positive germs.
The right way to self-fuse bi- and terpyrenyls to afford graphenic cutouts (2013)

In this work, we subject bi- and terpyrenyls to selective fusion for formation of extended polycyclic aromatic hydrocarbons (PAHs). Connecting the pyrene units at 4-4'- or 1-4'-positions led to smooth formation of extended PAHs, achieved via cyclodehydrogenation. This is far more difficult if pyrene is coupled in the 1,1'-position.
Effects of Clonidine on the Dermal Inflammatory Cell Response of Experimental Toxic and Allergic Contact Reactions and Intradermal Hypersensitivity (1987)

In previous studies, the alpha 2-adrenoceptor agonist clonidine has been shown to suppress the wheal and flare reaction in guinea pigs sensitized to ovalbumin. This phenomenon has been further studied with special reference to effects on the dermal inflammatory cell infiltrate and mast cells. Clonidine lessens the degranulation of mast cells seen in control untreated immediate hypersensitivity reactions. Less neutrophils and eosinophils arrive to the treated reactions. Basophils and mononuclear cells (chiefly lymphocytes) which characterize the late phase of the wheal and flare reaction were not influenced by clonidine. Clonidine had a possible minimal effect on allergic contact (delayed hypersensitivity) reactions. The toxic contact reaction to croton oil (nonspecific cutaneous inflammation) was not affected.
Cyr61 is up‐regulated in prostate cancer and associated with the <i>p53</i> gene status (2009)

Cysteine-rich 61 (Cyr61) is a member of the CCN protein family that has been implicated in diverse biological processes such as cell adhesion, proliferation, angiogenesis, and tumorigenesis. Altered expression of Cyr61 is found to be associated with human cancers. Here we show that Cyr61 was up-regulated in prostate cancer cell lines and tumor tissues. A significant correlation of Cyr61 expression was found between benign prostatic hyperplasia and prostate cancer (P = 0.002). However, there was no significant correlation between levels of PSA and Cyr61 expression (P = 0.2). Cyr61 may represent an independent prostate cancer biomarker and potentially a useful therapeutic target for prostate cancer treatment. In addition, our analysis based on published data and data present in this report indicted that levels of Cyr61 expression associated with the status of the tumor suppressor gene p53 in 32 cancer cell lines analyzed, high levels of Cyr61 expression were found in cell lines with mutant or null p53 gene, whereas lower expression levels of Cyr61 in the cell lines with wild-type p53. We further show that over-expression of dominant negative p53 or down-expression of endogenous wild-type p53 resulted in up-regulation of Cyr61 expression, suggesting a functional link between Cyr61 and p53 in cancers.