gebhart/patrepeval huggingface dataset:
The high-affinity IgE receptor (FcεRI) blocks apoptosis in normal human monocytes (2000)

Monocytes have a limited life span, and their homeostasis is regulated by apoptosis in vivo. When cultured in the absence of appropriate exogenous stimuli, they undergo apoptosis, but under the influence of survival signals, these cells differentiate into macrophages or dendritic cells. Here we show that ligation of the high-affinity IgE receptor (FcepsilonRI) on human monocytes from nonatopic individuals markedly reduces apoptosis induced by serum deprivation or by CD95/Fas ligation. Aggregation of FcepsilonRI reduces its own expression but fails to modulate CD95/Fas expression. In contrast, FcepsilonRI ligation enhances the expression of the antiapoptotic molecules Bcl-2 and Bcl-xL, but not Mcl-1, in monocytes. Incubation of unstimulated cells with culture supernatants of FcepsilonRI-activated monocytes prolongs their life span, whereas CD95/Fas expression remains unaffected. The incidence of apoptosis is restored considerably when the supernatant is depleted of TNF-alpha, whereas elimination of IL-1beta, GM-CSF, or IL-12 has no effect. These results indicate that FcepsilonRI mediates signals preventing monocyte apoptosis directly by increasing the levels of Bcl-2 and Bcl-xL, and indirectly by means of TNF-alpha in an autocrine and paracrine fashion. This process may contribute to the establishment of chronic allergic disorders such as atopic dermatitis.
The Planar Circuit - An Approach to Microwave Integrated Circuitry (1972)

Three principal categories have been known in electrical circuitry so far. They are the lumped-constant (0-dimensional) circuit, distributed-constant (1-dimensional) circuit, and waveguide (3-dimensional) circuit. The planar circuit to be discussed in general in this paper is a circuit category that should be positioned as a 2-dimensional circuit. It is defined as an "electrical circuit having dimensions comparable to the wavelength in two directions, but much less thickness in one direction." The main subject of this paper is the computer analysis of an arbitrarily shaped, triplate planar circuit. It is shown that a computer analysis based upon a contour-integral solution of the wave equation offers an accurate and efficient tool in the design of the planar circuit. Results of some computer calculations are described. It is also shown that the circuit parameters can be derived directly from Green's function of the wave equation when the shape of the circuit is relatively simple. Examples of this sort of analysis are also shown for comparison with the computer analysis.
Cost-effectiveness of interventions promoting physical activity (2008)

There was evidence that current physical activity intervention strategies can be a cost-effective means of resource allocation. But, despite the growing literature on physical activity promotion, appropriate cost-effectiveness analyses are rare and the generalisability of presented findings is limited. Further research is warranted to investigate the cost-effectiveness of behavioural and environmental intervention strategies.
Applications of Photoinitiated Cationic Polymerization to the Development of New Photoresists (1984)

The recent development of several new classes of highly efficient photoinitiators for cationic polymerization makes possible their application in the design of novel photoresists. The concepts on which these imaging processes are based are set forth in this article.
Analysis and realization study of a 1-kW phase-shift full-bridge converter with current-doubler rectifier for battery charging (2016)

This paper presents a 1-kW phase-shift full-bridge (PS-FB) converter with a toroid-core-wound autotransformer for current-doubler rectifier (TCWA-CDR), which acts as current source for battery charging. Comparing to the use of one-inductor rectifier, in continuous-conduction mode (CCM), the valid duty of the PS-FB converter with the proposed CDR can be extended due to small transition period. In particular, in close to discontinuous-conduction mode (DCM), there is no transition period appearing in the primary current ip, which leads the four primary switches and the two secondary diodes switching at close to zero-current switching (ZCS). Thus, the efficiency of this topology can be as high as over 92%.
The histidine kinase-related domain participates in phytochrome B function but is dispensable (2000)

Phytochromes are photoreceptors that control many plant light responses. Phytochromes have two carboxyl-terminal structural domains called the PAS repeat domain and the histidine kinase-related domain. These domains are each related to bacterial histidine kinase domains, and biochemical studies suggest that phytochromes are light-regulated kinases. The PAS repeat domain is important for proper phytochrome function and can interact with putative signaling partners. We have characterized several new phytochrome B mutants in Arabidopsis that express phyB protein, three of which affect the histidine kinase-related domain. Point mutations in the histidine kinase-related domain cause phenotypes similar to those of null mutants, indicating that this domain is important for phyB signaling. However, a truncation that removes most of the histidine kinase-related domain results in a phyB molecule with partial activity, suggesting that this domain is dispensable. These results suggest that phytochromes evolved in modular fashion. We discuss possible functions of the histidine kinase-related domain in phytochrome signaling.
Spintronic Device Based Non-volatile Low Standby Power SRAM (2008)

SRAM is an indispensable component in modern microprocessors to store copies of the most frequently used data from the main memory. The high write/read speed of SRAM assures the desired memory throughput required by the internal high operating frequency of the microprocessor. However SRAM memory is volatile, which causes some drawbacks for computer systems such as high standby power and low data security etc. Spintronic devices as magnetic tunnel junction (MTJ) features non-volatility, high write/read speed and exhibits good interface with CMOS. They have therefore the potential to overcome the SRAM limitations. In this paper, we present a Non-Volatile SRAM that combines MTJ devices with classical SRAM. Used in a microprocessor, it can ldquosnapshotrdquo the currently-executing program and data from SRAM to the relating MTJ cells at regular intervals. If its power supply is interrupted, this self-checkpointing processor can near-instantly (~700 ps) restore its state from the last checkpoint, allowing it to resume execution with little loss of progress. The non-volatility of MTJ and the high data recovering speed allows the NVSRAM to consume nearly zero standby power.
Inverse Parameter Identification Technique Using PSO Algorithm Applied to Geotechnical Modeling (2008)

This paper presents a concept for the application of particle swarm optimization in geotechnical engineering. For the calculation of deformations in soil or rock, numerical simulations based on continuum methods are widely used. The material behavior is modeled using constitutive relations that require sets of material parameters to be specified. We present an inverse parameter identification technique, based on statistical analyses and a particle swarm optimization algorithm, to be used in the calibration process of geomechanical models. Its application is demonstrated with typical examples from the fields of soil mechanics and engineering geology. The results for two different laboratory tests and a natural slope clearly show that particle swarms are an efficient and fast tool for finding improved parameter sets to represent the measured reference data.
Influence of pH and Ionic Strength on Formation and Stability of Emulsions Containing Oil Droplets Coated by β-Lactoglobulin−Alginate Interfaces (2006)

Emulsions of 0.1 wt % corn oil-in-water containing oil droplets coated by beta-lactoglobulin (0.009 wt % beta-Lg, 5 mM phosphate buffer, pH 7.0) were prepared in the absence and presence of sodium alginate (0 or 0.004 wt %). The pH (3-7) and ionic strength (0-250 mM NaCl) of these emulsions were adjusted, and the particle charge, particle size, and creaming stability were measured. Alginate adsorbed to the beta-Lg-coated droplets from pH 3 to 6, which was attributed to electrostatic attraction between the anionic polymer and cationic patches on the droplet surfaces. Droplets coated by beta-Lg-alginate had better stability to flocculation than those coated by beta-Lg alone, especially around the isoelectric point of the adsorbed proteins and at low ionic strengths (< 100 mM NaCl). At pH 5, alginate molecules desorbed from the droplet surfaces at high salt concentrations due to weakening of the electrostatic attraction.
Role of the invariant aspartic acid 99 of human choriogonadotropin beta in receptor binding and biological activity. (1991)

The four human glycoprotein hormones are heterodimers that contain a common alpha subunit and a hormone-specific beta subunit. Within this hormone family, 23 amino acid sequences from 11 mammalian species are available. There are 19 invariant amino acid residues in the beta subunits, 12 of which are Cys that form six disulfide bonds. Of the remaining seven conserved amino acid residues, we have investigated the role of an Asp which occurs at position 99 in human choriogonadotropin beta (hCG beta). Site-directed mutagenesis was used to replace hCG beta Asp99 with three residues, Glu, Asn, and Arg, and to prepare an inversion double mutant protein, Arg94----Asp and Asp99----Arg. The cDNAs were placed in a eukaryotic expression vector, and the plasmids were transiently transfected into Chinese hamster ovary cells containing a stably integrated gene for bovine alpha. Radioimmunoassays demonstrated that the mutant forms of hCG beta were capable of subunit assembly to the same extent as hCG beta wild type. The heterologous heterodimers were assayed in vitro using transformed mouse Leydig cells (MA-10) by competitive inhibition of 125I-hCG binding and stimulation of progesterone production. The gonadotropins containing Glu and Asn were active, although the potency was less than that associated with the hCG beta wild type-containing gonadotropin. In contrast, the Arg99-containing mutant protein and the inversion mutant protein Asp94/Arg99 were devoid of activity. Thus, in hCG beta Asp99 can be substituted with certain residues without total loss of function, although replacement with a positively charged residue leads to an inactive heterodimer. The primary role of Asp99 in hCG beta seems to involve, either directly or indirectly, receptor recognition.
Herbivory Rapidly Activates MAPK Signaling in Attacked and Unattacked Leaf Regions but Not between Leaves of <i>Nicotiana attenuata</i> (2007)

Mitogen-activated protein kinase (MAPK) signaling plays a central role in transducing extracellular stimuli into intracellular responses, but its role in mediating plant responses to herbivore attack remains largely unexplored. When Manduca sexta larvae attack their host plant, Nicotiana attenuata, the plant's wound response is reconfigured at transcriptional, phytohormonal, and defensive levels due to the introduction of oral secretions (OS) into wounds during feeding. We show that OS dramatically amplify wound-induced MAPK activity and that fatty acid-amino acid conjugates in M. sexta OS are the elicitors. Virus-induced gene silencing of salicylic acid-induced protein kinase (SIPK) and wound-induced protein kinase revealed their importance in mediating wound and OS-elicited hormonal responses and transcriptional regulation of defense-related genes. We found that after applying OS to wounds created in one portion of a leaf, SIPK is activated in both wounded and specific unwounded regions of the leaf but not in phylotactically connected adjacent leaves. We propose that M. sexta attack elicits a mobile signal that travels to nonwounded regions of the attacked leaf where it activates MAPK signaling and, thus, downstream responses; subsequently, a different signal is transported by the vascular system to systemic leaves to initiate defense responses without activating MAPKs in systemic leaves.
A selective role for corticosterone in contextual-fear conditioning. (1997)

The contribution of corticosterone to contextual- and auditory-cue fear conditioning was examined. Adrenalectomized rats showed reduced contextual-fear conditioning when tested 24 hr after conditioning; however, neither immediate contextual- nor auditory-cue fear conditioning was impaired. Contextual-fear conditioning in adrenalectomized rats with corticosterone replacement during the 4-day interval separating surgery and conditioning matched the level of controls. Moreover, rats exposed to the context prior to adrenalectomy showed normal long-term contextual-fear conditioning. Corticosterone replacement administered after the conditioning episode also negated the effects of adrenalectomy. Thus, corticosterone's role in fear conditioning is selective: It appears to contribute to the neural processes that support the consolidation of a long-term memory representation of the context.
Huge Dentigerous Cyst in Maxillary Sinus : A Cause of Recurrent Sinusitis in an Adolescent (2011)

Dentigerous cysts are the most common type of develomental odontogenic cysts and the second most common odontogenic cyst of jaw after radicular cysts. Although a rare cause of sinusitis in children, dentigerous cysts should be included in differential diagnosis for cause of persistent or recurrent sinusitis in this age group. We report an unusual case of a huge dentigerous cyst in maxillary sinus presenting as recurrent sinusitis in an adolescent. (J Clinical Otolaryngol 2011;22:231-234)
Blood glucose monitoring in diabetes (2014)

While the prevalence of all types of chronic conditions is increasing, diabetes is one of the few long-term conditions that individuals can successfully manage and control on a day-to-day basis, providing that they have access to appropriate advice and support. Blood glucose monitoring and patient education are essential in diabetes care and management, and if used appropriately, can help to achieve maximum benefit for the patient and diabetes care team. This article considers the link between blood glucose levels and the incidence of diabetes-related complications. It explores the different blood glucose monitoring strategies, particularly self-monitoring of blood glucose in people with type 2 diabetes. The frequency of blood glucose monitoring, and the identification of patterns and trends in blood glucose control are highlighted and applied to practice.
Sequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction (2001)

Three different base paired stems form between U2 and U6 snRNA over the course of the mRNA splicing reaction (helices I, II and III). One possible function of U2/U6 helix II is to facilitate subsequent U2/U6 helix I and III interactions, which participate directly in catalysis. Using an in vitro trans-splicing assay, we investigated the function of sequences located just upstream from the branch site (BS). We find that these upstream sequences are essential for stable binding of U2 to the branch region, and for U2/U6 helix II formation, but not for initial U2/BS pairing. We also show that non-functional upstream sequences cause U2 snRNA stem-loop IIa to be exposed to dimethylsulfate modification, perhaps reflecting a U2 snRNA conformational change and/or loss of SF3b proteins. Our data suggest that initial binding of U2 snRNP to the BS region must be stabilized by an interaction with upstream sequences before U2/U6 helix II can form or U2 stem-loop IIa can participate in spliceosome assembly.
From Midbody Protein−Protein Interaction Network Construction to Novel Regulators in Cytokinesis (2009)

Midbody, a transient organelle-like structure, is known as central for abscission and is indispensable for termination of cytokinesis. Here, we used the midbody proteome inventories to construct the potential midbody protein-protein interaction (PPI) network. To delineate novel regulators participating in cytokinesis, the z-score, a standard statistic score, rather than hub degree was implemented to prioritize the novel hubs. Of these hubs, KIAA0133, SEPT1, KIAA1377, and CRMP-1 were localized to the midbody, whereas HTR3A and ICAM2 were associated with the cleavage furrow as examined by immunofluorescence. Knockdown of SEPT1 and KIAA1377 resulted in increasing numbers of cytokinesis defect cells, suggesting these newly identified hubs play critical roles in cytokinesis progression. Moreover, ectopic expression of CRMP-1 mutant in which Aurora-A phosphorylation sites have been replaced with Ala results in a cytokinesis defect. This subproteome network construction not only sheds light on the intimate interactions of the midbody proteomes, but also prioritizes novel hubs or protein complexes that may govern the process of cytokinesis.
The p53 gene in pediatric therapy-related leukemia and myelodysplasia (1996)

We investigated the frequency of p53 mutations in 19 pediatric cases of therapy-related leukemia or myelodysplastic syndrome. Eleven children presented with acute myeloid leukemia, one with mixed-lineage leukemia, two with acute lymphoblastic leukemia, and five with myelodysplasia at times ranging from 11 months to 9 years after a primary cancer diagnosis. The primary cancers, which included 11 solid tumors and eight leukemias, were treated with various combinations of DNA topoisomerase II inhibitors, alkylating agents, or irradiation. Leukemic or myelodysplastic marrows were screened for possible mutations by single-strand conformation polymorphism (SSCP) analysis of p53 exons 4 to 8. The only observed mutation was an inherited 2-basepair deletion at codon 209 in exon 6 that would shift the open reading frame, create a premature termination codon, and foreshorten the resultant protein. Prior therapy in this patient included DNA topoisomerase II inhibitors, alkylating agents, and irradiation. The secondary leukemia presented as myelodysplasia with monosomies of chromosomes 5 and 7 and abnormalities of chromosome 17. Although the primary cancer was an embryonal rhabdomyosarcoma and there was a family history of cancer, the case did not fulfill the clinical criteria for Li-Fraumeni syndrome. This study suggests that germline p53 mutations may predispose some children to therapy-related leukemia and myelodysplasia, but that p53 mutations otherwise are infrequent in this setting.
Aerosol Susceptibility of Influenza Virus to UV-C Light (2012)

The person-to-person transmission of influenza virus, especially in the event of a pandemic caused by a highly virulent strain of influenza, such as H5N1 avian influenza, is of great concern due to widespread mortality and morbidity. The consequences of seasonal influenza are also substantial. Because airborne transmission appears to play a role in the spread of influenza, public health interventions should focus on preventing or interrupting this process. Air disinfection via upper-room 254-nm germicidal UV (UV-C) light in public buildings may be able to reduce influenza transmission via the airborne route. We characterized the susceptibility of influenza A virus (H1N1, PR-8) aerosols to UV-C light using a benchtop chamber equipped with a UVC exposure window. We evaluated virus susceptibility to UV-C doses ranging from 4 to 12 J/m(2) at three relative humidity levels (25, 50, and 75%). Our data show that the Z values (susceptibility factors) were higher (more susceptible) to UV-C than what has been reported previously. Furthermore, dose-response plots showed that influenza virus susceptibility increases with decreasing relative humidity. This work provides an essential scientific basis for designing and utilizing effective upper-room UV-C light installations for the prevention of the airborne transmission of influenza by characterizing its susceptibility to UV-C.
Dynamic Modelling of Axle Tramp in a Sport Type Car (2013)

One of the most significant dynamic aspects of coupled vibration of transmission system and dependent type suspension systems is axle tramp. The tramp is defined as undesirable oscillation of rigid live axle around roll axis. In spite of utilizing powerful engines in some type of sport cars, tramp occurrence causes loss of longitudinal performance. The aim of this paper is to derive a mathematical model for predicting and classifying of the tramp. A parameter study reveals that, some parameters such as engine torque, moving parts moment of inertia, car and wheels weight and the material used in suspension system play important role in controlling the tramp. It is shown that large difference between sprung and unsprung mass moment of inertia around the roll-axis, low vehicle mass, short rear track and medium damping values have significant effects on the severity of tramp.
A randomized comparison of a durable polymer Everolimus-eluting stent with a bare metal coronary stent: The SPIRIT first trial. (2005)

Everolimus eluted from a durable polymer on a cobalt chromium stent effectively suppresses neointimal growth at 6 months compared to an identical bare stent.
Tyrosine Hydroxylase and DOPA Decarboxylase Gene Variants in Personality Traits (2009)

Personality influences several characteristics of normal and pathologic behaviors and it is associated with neurotransmitter systems that are under genetic control. The dopaminergic system has been proposed to play a role in the modulation of personality traits. In the present study, variants of the tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC) genes (for TH: rs3842727, rs6356; for DDC: rs1451371, rs1470750, rs998850) were investigated in 111 suicide attempters and 289 healthy subjects to assess the involvement of the dopaminergic synthesis pathway in personality traits. No strong evidence was found for the associations between personality and TH or DDC in overall tests. An interaction effect of genotype and diagnosis was present, with TH and DDC SNPs having a greater effect on the respective personality dimensions in the group of suicide attempters. Because of the risk of false positives, these findings should be interpreted with highest caution. Direct replication attempts within independent groups of suicide attempters will help to resolve this question.
Ultrasonographic measurement of median nerve cross‐sectional area in idiopathic carpal tunnel syndrome: Diagnostic accuracy (2002)

Severity-correlated enlargement of the median nerve occurs in idiopathic carpal tunnel syndrome (CTS). We determined whether measurement of the nerve cross-sectional area was useful in making the diagnosis of CTS. In 414 wrists of 275 patients with clinically diagnosed idiopathic CTS and 408 wrists of 408 controls, we made ultrasonographic measurements of the nerve area at the distal (distal edge of the flexor retinaculum), mid (hook of the hamate), and proximal carpal tunnel (wrist crease). Criteria based on the area at a single level yielded sensitivities of 43-57% and specificities of 96-97%. Use of the mean carpal nerve area (average of the areas at the three levels) improved the results (sensitivity, 67%; specificity, 97%), which was as sensitive as the nerve conduction studies (NCS). In the NCS, we obtained sensitivities of 66% for the distal motor nerve latency and 67% for the distal sensory nerve latency, with specificities of 97% for each. A combination of the mean carpal nerve area and NCS criteria yielded a sensitivity of 84% and a specificity of 94%. The clinical implications of these findings for the diagnosis of CTS are discussed.