gebhart/patrepeval huggingface dataset:
A robust detection algorithm to identify breathing peaks in respiration signals from spontaneously breathing subjects (2015)

Assessing respiratory and cardiovascular system coupling can provide new insights into disease progression, but requires accurate analysis of each signal. Respiratory waveform data collected during spontaneous breathing are noisy and respiration rates from long term physiological experiments can vary over a wide range across time. There is a need for automatic and robust algorithms to detect breathing peaks in respiration signals for assessment of the coupling between the respiratory and cardiovascular systems. We developed an automatic algorithm to detect breathing peaks from a respiration signal. The algorithm was tested on respiration signals collected during hemorrhage in a conscious ovine model (N=9, total length = 11.0h). The breathing rate varied from 15 to as high as 160 breaths/min for some animals during the hemorrhage protocol. The sensitivity of the algorithm to detect respiration peaks was 93.7% with a precision of 94.5%. The developed algorithm presents a promising approach to detect breathing peaks in respiration signals from spontaneously breathing subjects. The algorithm was able to consistently identify breathing peaks while the breathing rate varied from 15 to 160 breaths/min.
Assessment and Treatment of Abuse Risk in Opioid Prescribing for Chronic Pain (2011)

Opioid analgesics provide effective treatment for noncancer pain, but many physicians have concerns about adverse effects, tolerance, and addiction. Misuse of opioids is prominent in patients with chronic back pain and early recognition of misuse risk could help physicians offer adequate patient care while implementing appropriate levels of monitoring to reduce aberrant drug-related behaviors. In this review, we discuss opioid abuse and misuse issues that often arise in the treatment of patients with chronic back pain and present an overview of assessment and treatment strategies that can be effective in improving compliance with the use of prescription opioids for pain. Many persons with chronic back pain have significant medical, psychiatric and substance use comorbidities that affect treatment decisions and a comprehensive evaluation that includes a detailed history, physical, and mental health evaluation is essential. Although there is no "gold standard" for opioid misuse risk assessment, several validated measures have been shown to be useful. Controlled substance agreements, regular urine drug screens, and interventions such as motivational counseling have been shown to help improve patient compliance with opioids and to minimize aberrant drug-related behavior. Finally, we discuss the future of abuse-deterrent opioids and other potential strategies for back pain management.
Iron Nitrosyls of a Pentadentate Ligand Containing a Single Carboxamide Group:  Syntheses, Structures, Electronic Properties, and Photolability of NO (2003)

Three iron complexes of a pentadentate ligand N,N-bis(2-pyridylmethyl)amine-N-ethyl-2-pyridine-2-carboxamide (PaPy(3)H, H is the dissociable amide proton) have been synthesized. All three species, namely, two nitrosyls [(PaPy(3))Fe(NO)](ClO(4))(2) (2) and [(PaPy(3))Fe(NO)](ClO(4)) (3) and one nitro complex [(PaPy(3))Fe(NO(2))](ClO(4)) (4), have been structurally characterized. These complexes provide the opportunity to compare the structural and spectral properties of a set of isostructural [Fe-NO](6,7) complexes (2 and 3, respectively) and an analogous genuine Fe(III) complex with an "innocent" sixth ligand ([(PaPy(3))Fe(NO(2))](ClO(4)), 4). The most striking difference in the structural features of 2 and 3 is the Fe-N-O angle (Fe-N-O = 173.1(2) degrees in the case of 2 and 141.29(15) degrees in the case of 3). The clean (1)H NMR spectrum of 2 in CD(3)CN reveals its S = 0 ground state and confirms its [Fe-NO](6) configuration. The binding of NO at the non-heme iron center in 2 is completely reversible and the bound NO is photolabile. Mössbauer data, electron paramagnetic resonance signal at g approximately 2.00, and variable temperature magnetic susceptibility measurements indicate the S = (1)/(2) spin state of the [Fe-NO](7) complex 3. Analysis of the spectroscopic data suggests Fe(II)-NO(+) and Fe(II)-NO(*) formulations for 2 and 3, respectively. The bound NO in 3 does not show any photolability. However, in MeCN solution, it reacts rapidly with dioxygen to afford the nitro complex 4, which has also been synthesized independently from [(PaPy(3))Fe(MeCN)](2+) and NO(2)(-). Nucleophilic attack of hydroxide ion to the N atom of the NO ligand in 2 in MeCN in the dark gives rise to 4 in high yield.
Complex water effects at interactive frame rates (2003)

Due to the complexity of the effects, it is difficult to achieve photorealism and physically correct motion in\ninteractive 3-D water simulations. We present a simulation and visualization method which goes a long way\ntowards physical reality, e. g. by producing Kelvin ship waves and displaying images of real caustics on the water\nsurface. Using efficient approximations and employing the specialized 3-D and CPU features of modern PCs,\nthis simulation runs at rates of several frames per second. Part of this solution is the emulation of a hardware\naccumulation buffer on consumer 3-D graphics cards with the help of texture shaders.
Removal of Mercury from Chloralkali Electrolysis Wastewater by a Mercury-Resistant <i>Pseudomonas putida</i> Strain (1999)

A mercury-resistant bacterial strain which is able to reduce ionic mercury to metallic mercury was used to remediate in laboratory columns mercury-containing wastewater produced during electrolytic production of chlorine. Factory effluents from several chloralkali plants in Europe were analyzed, and these effluents contained total mercury concentrations between 1.6 and 7.6 mg/liter and high chloride concentrations (up to 25 g/liter) and had pH values which were either acidic (pH 2.4) or alkaline (pH 13.0). A mercury-resistant bacterial strain, Pseudomonas putida Spi3, was isolated from polluted river sediments. Biofilms of P. putida Spi3 were grown on porous carrier material in laboratory column bioreactors. The bioreactors were continuously fed with sterile synthetic model wastewater or nonsterile, neutralized, aerated chloralkali wastewater. We found that sodium chloride concentrations up to 24 g/liter did not inhibit microbial mercury retention and that mercury concentrations up to 7 mg/liter could be treated with the bacterial biofilm with no loss of activity. When wastewater samples from three different chloralkali plants in Europe were used, levels of mercury retention efficiency between 90 and 98% were obtained. Thus, microbial mercury removal is a potential biological treatment for chloralkali electrolysis wastewater.
CCL2 is a Potent Regulator of Prostate Cancer Cell Migration and Proliferation (2006)

Tumor cells in the bone interact with the microenvironment to promote tumor cell survival and proliferation, resulting in a lethal phenotype for patients with advanced prostate cancer. Monocyte chemoattractant protein 1 (CCL2) is a member of the CC chemokine family and is known to promote monocyte chemotaxis to sites of inflammation. Here we have shown that human bone marrow endothelial (HBME) cells secrete significantly higher levels of CCL2 compared to human aortic endothelial cells and human dermal microvascular endothelial cells. Furthermore, we demonstrate that CCL2 is a potent chemoattractant of prostate cancer epithelial cells, and that stimulation of PC-3 and VCaP cells resulted in a dose-dependent activation of PI3 kinase/Akt signaling pathway. Activation of the PI3 kinase/Akt pathway was found to be vital to the proliferative effects of CCL2 stimulation of both PC-3 and VCaP cells. Additionally, CCL2 stimulated the phosphorylation of p70-S6 kinase (a downstream target of Akt) and induced actin rearrangement, resulting in a dynamic morphologic change indicative of microspike formation. These data suggest that bone marrow endothelial cells are a major source of CCL2, and that an elevated secretion of CCL2 recruits prostate cancer epithelial cells to the bone microenvironment and regulates their proliferation rate.
Pathophysiology of functional dyspepsia (2002)

Functional dyspepsia is a symptom complex characterised by postprandial upper abdominal discomfort or pain, early satiety, nausea, vomiting, abdominal distension, bloating, and anorexia in the absence of organic disease. Gastrointestinal motor abnormalities, altered visceral sensation, and psychosocial factors have all been identified as major pathophysiological mechanisms. This perspective has now replaced the earlier view that the condition was the result of a sole motor or sensory disorder of the stomach. Future therapeutic strategies should be aimed at reducing nociception as well as enhancing the accommodation response.
High-throughput Assays for Superoxide and Hydrogen Peroxide (2014)

Recent progress characterizing the reaction mechanism(s) of fluorescent probes with reactive oxygen species has made it possible to rigorously analyze these reactive species in biological systems. We have developed rapid high throughput-compatible assays for monitoring cellular production of superoxide radical anion and hydrogen peroxide using hydropropidine and coumarin boronic acid probes, respectively. Coupling plate reader-based fluorescence measurements with HPLC-based simultaneous monitoring of superoxide radical anion and hydrogen peroxide provides the basis for the screening protocol for NADPH oxidase (Nox) inhibitors. Using this newly developed approach along with the medium-throughput plate reader-based oximetry and EPR spin trapping as confirmatory assays, it is now eminently feasible to rapidly and reliably identify Nox enzyme inhibitors with a markedly lower rate of false positives. These methodological advances provide an opportunity to discover selective inhibitors of Nox isozymes, through enhanced conceptual understanding of their basic mechanisms of action.
Glucosinolate content of seedlings, tissue cultures, and regenerant plants of Brassica juncea (Indian mustard) (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlucosinolate content of seedlings, tissue cultures, and regenerant plants of Brassica juncea (Indian mustard)Martin V. Palmer, Stella P. Yeung, and Joseph P. SangCite this: J. Agric. Food Chem. 1987, 35, 2, 262–265Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/jf00074a024https://doi.org/10.1021/jf00074a024research-articleACS PublicationsRequest reuse permissionsArticle Views281Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ß-lnterferon Treatment of Cervical Intraepithelial Neoplasia: A Multicenter Clinical Trial (1995)

Forty-nine women with cervical intraepithelial neoplasia (CIN) grade II were treated with systemic and/or local beta-interferon (beta-IFN) applications. The aim of the study was to compare the efficacy of different routes for the administration of beta-IFN, evaluate local and systemic beta-IFN tolerance, and determine whether disappearance of neoplastic lesions was related to the resolution of the concomitant human papillomavirus infection. The patients were randomized to receive intramuscular, intralesional or a combination of intramuscular and intralesional administration, or conventional treatment. Significant differences in the rate of lesion regression were observed between treated and untreated women. The highest frequency of complete response was observed with the therapy combining intramuscular and intralesional treatment.
Interfering Residues Narrow the Spectrum of MLV Restriction by Human TRIM5α (2007)

TRIM5alpha is a restriction factor that limits infection of human cells by so-called N- but not B- or NB-tropic strains of murine leukemia virus (MLV). Here, we performed a mutation-based functional analysis of TRIM5alpha-mediated MLV restriction. Our results reveal that changes at tyrosine(336) of human TRIM5alpha, within the variable region 1 of its C-terminal PRYSPRY domain, can expand its activity to B-MLV and to the NB-tropic Moloney MLV. Conversely, we demonstrate that the escape of MLV from restriction by wild-type or mutant forms of huTRIM5alpha can be achieved through interdependent changes at positions 82, 109, 110, and 117 of the viral capsid. Together, our results support a model in which TRIM5alpha-mediated retroviral restriction results from the direct binding of the antiviral PRYSPRY domain to the viral capsid, and can be prevented by interferences exerted by critical residues on either one of these two partners.
Peptide Treatment of Postgastrectomy Obstruction (1976)

Seventeen patients with symptoms of acute or chronic postgastrectomy obstruction of a life-threatening nature have been treated with a peptide substance that is isolated from the bovine neurohypophysis (coherin) and has a regularizing effect on the electromotor performance of the small intestine of the dog and man. All patients treated in this study were relieved of their obstructive symptoms. After weight gain began, the majority of patients with acute obstruction were able to discontinue coherin therapy. Five patients with chronic obstruction have required prolonged treatment with coherin to maintain normal alimentary function.
The new intelligent power modules with Reverse conducting IGBTs and SOI driver for low power motor drives (2010)

This paper presents a new CIPOS™ (Control Integrated Power System) in DIL (Dual-in-line) package, which combines with the features of Infineon trench field stop RC (Reverse conducting) IGBT and a newly optimized Infineon SOI (Silicon On Insulator) gate driver to achieve the excellent solution for upto 2.5kW motor drives. It also comes along with flexible internal schematics, which are tailor made for the target applications by using the combination of PCB and lead-frame. This paper provides an overall description of the new CIPOS™ module as well as performance, power ratings, adopted RC-IGBT and SOI gate driver.
Polymers from renewable resources. II. A study in the radio chemical grafting of poly(styrene‐alt‐maleic anhydride) onto cellulose extracted from pine needles (1999)

A binary mixture of styrene and maleic anhydride has been graft copolymerized onto cellulose extracted from Pinus roxburghii needles. The reaction was initiated with gamma rays in air by the simultaneous irradiation method. Graft copolymerization was studied under optimum conditions of total dose of radiation, amount of water, and molar concentration previously worked out for grafting styrene onto cellulose. Percentage of total conversion (Pg), grafting efficiency (%), percentage of grafting (Pg), and rates of polymerization (Rp), grafting (Rg), and homopolymerization (Rh) have been determined as a function of maleic anhydride concentration. The high degree of kinetic regularity and the linear dependence of the rate of polymerization on maleic anhydride concentration, along with the low and nearly constant rate of homopolymerization suggest that the monomers first form a complexomer which then polymerizes to form grafted chains with an alternating sequence. Grafting parameters and reaction rates achieve maximum values when the molar ratio of styrene to maleic anhydride is 1 : 1. Further evidence for the alternating monomer sequence is obtained from quantitatively evaluating the composition of the grafted chains from the FT-IR spectra, in which the ratio of anhydride absorbance to aromatic (CC) absorbance for the stretching bands assigned to the grafted monomers remained constant and independent of the feed ratio of maleic anhydride to styrene. Thermal behaviour of the graft copolymers revealed that all graft copolymers exhibit single stage decomposition with characteristic transitions at 161–165°C and 290–300°C. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 1763–1769, 1999
Issue of Event Sequence in time of Distributed Intrusion Detection System (2007)

Distributed intrusion detection system (DIDS) is one of important devices for information security. In this field, how to improve detection rate is one of key issues. In this paper, the importance of event sequence in time is presented. Then, we discuss three factors, i.e. timestamp precision, time synchronization and network delay, which effect detection rate on the view of event sequence in time. On the three aspects, timestamp precision is the key to keep internal event sequence, time synchronization is the base of correcting event sequence among computers, and that network delay makes time-series analysis not true. Accordingly, we address some methods, i.e. raising timestamp precision, active self- adapting time synchronization algorithm and state turnabout mechanism. Experiments indicate that anyone of three measures can elevate detection performance to a certain extent. If they all are adopted, better detection results are revealed.
A Unique Zinc-Binding Site Revealed by a High-Resolution X-ray Structure of Homotrimeric Apo2L/TRAIL (2000)

Apoptosis-inducing ligand 2 (Apo2L, also called TRAIL), a member of the tumor necrosis factor (TNF) family, induces apoptosis in a variety of human tumor cell lines but not in normal cells [Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., and Goodwin, R. G. (1995) Immunity 3, 673-682; Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., and Ashkenazi, A. (1996) J. Biol. Chem. 271, 12687-12690]. Here we describe the structure of Apo2L at 1.3 A resolution and use alanine-scanning mutagenesis to map the receptor contact regions. The structure reveals a homotrimeric protein that resembles TNF with receptor-binding epitopes at the interface between monomers. A zinc ion is buried at the trimer interface, coordinated by the single cysteine residue of each monomer. The zinc ion is required for maintaining the native structure and stability and, hence, the biological activity of Apo2L. This is the first example of metal-dependent oligomerization and function of a cytokine.
Photochemical reactions in organized assemblies. 37. Photochemistry and photophysics of surfactant trans-stilbenes in supported multilayers and films at the air-water interface (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical reactions in organized assemblies. 37. Photochemistry and photophysics of surfactant trans-stilbenes in supported multilayers and films at the air-water interfaceWilliam F. Mooney III, Patti E. Brown, John C. Russell, Lee G. Pedersen, and David G. WhittenCite this: J. Am. Chem. Soc. 1984, 106, 19, 5659–5667Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/ja00331a041https://doi.org/10.1021/ja00331a041research-articleACS PublicationsRequest reuse permissionsArticle Views308Altmetric-Citations119LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
An Alpaca Nanobody Inhibits Hepatitis C Virus Entry And Cell-To-Cell Transmission (2013)

This is the first description of a potent and broadly neutralizing HCV-specific nanobody representing a significant advance that will lead to future development of novel entry inhibitors for the treatment and prevention of HCV infection and help our understanding of HCV cell-to-cell transmission.
Proteomics in Melanoma Biomarker Discovery: Great Potential, Many Obstacles (2011)

The present clinical staging of melanoma stratifies patients into heterogeneous groups, resulting in the application of aggressive therapies to large populations, diluting impact and increasing toxicity. To move to a new era of therapeutic decisions based on highly specific tumor profiling, the discovery and validation of new prognostic and predictive biomarkers in melanoma is critical. Genomic profiling, which is showing promise in other solid tumors, requires fresh tissue from a large number of primary tumors, and thus faces a unique challenge in melanoma. For this and other reasons, proteomics appears to be an ideal choice for the discovery of new melanoma biomarkers. Several approaches to proteomics have been utilized in the search for clinically relevant biomarkers, but to date the results have been relatively limited. This article will review the present work using both tissue and serum proteomics in the search for melanoma biomarkers, highlighting both the relative advantages and disadvantages of each approach. In addition, we review several of the major obstacles that need to be overcome in order to advance the field.
Building up to macroprogramming: an intermediate language for sensor networks (2005)

There is widespread agreement that a higher level programming model for sensor networks is needed. A variety of models have been developed, but the community is far from consensus. We propose an intermediate language to speed up the exploration of this design space. Our language, called the token machine language (TML) can be targeted by compilers for higher level systems. TML provides a layer of abstraction for a lower-level runtime environment, such as TinyOS. TML is intended to capture coordinated activity in a sensor network. Notable features of TML are its atomic action model of concurrency, and its unification of communication, control, and storage around the concept of a token. Tokens are small objects, typically under a hundred bytes, and can be disseminated across the network. A token causes computation upon its arrival at a site by invoking a token handler. The effect of the computation is to atomically change the token's own state as well as the state of shared variables at the site.