gebhart/patrepeval huggingface dataset:
<i>aldehydo</i>-D-Galactose Heptaacetate and <i>aldehydo</i>-D-Xylose Hexaacetate from Acetolysis of Guaran and Xylan (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTaldehydo-D-Galactose Heptaacetate and aldehydo-D-Xylose Hexaacetate from Acetolysis of Guaran and XylanRoy L. Whistler, Eileen. Heyne, and Joseph. BachrachCite this: J. Am. Chem. Soc. 1949, 71, 4, 1476–1477Publication Date (Print):April 1, 1949Publication History Published online1 May 2002Published inissue 1 April 1949https://pubs.acs.org/doi/10.1021/ja01172a095https://doi.org/10.1021/ja01172a095research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sensors system design for discrimination between humans and animals (2016)

The applicability areas for sensor networks vary from industrial automation, environmental observation to medical domain [1]. As the quality of life has improved, the life expectancy also increased during the last years, fact that leads to an aging of the population. It is well known that elderly people need special treatment and resources due to their decreasing capacity of self-caring. It is, thus, desirable to increase the length of independent living for this category without depriving them from the known life environment and personal habits. Another possible application is the one of child care and monitoring in closed precincts. This paper illustrates the implementation steps of a sensor network used for discriminating between the presence of a human being and of an animal that may be useful in case of medical emergency situations. The design takes into account the main challenges that may occur such as achievement of not accurate results due to the fact that children are moving much more than an adult. The basic structure is designed using Arduino platform, sensors for distance measurements, for height determination as well as DHT22 temperature sensor and sensors for motion detection and takes into account cases of walking and standing subjects. Several configurations have been tested in order to improve the relative error for discrimination between children and pet entering a room.
Increased omeprazole metabolism in carriers of the <i>CYP2C19*17</i> allele; a pharmacokinetic study in healthy volunteers (2008)

The pharmacokinetics of omeprazole and omeprazole sulphone differ significantly between homozygous CYP2C19*17 and CYP2C19*1 subjects. For clinically important drugs that are metabolized predominantly by CYP2C19, the CYP2C19*17 allele might be associated with subtherapeutic drug exposure.
Terodiline treatment of detrusor hyperreflexia in sclerosis multiplex. (1989)

A single-blind placebo controlled study on the efficacy of the anticholinergic and calcium blocking agent terodiline (Mictrol) on detrusor hyperreflexia has been done in 10 patients with multiple sclerosis in a stable state. The patients were evaluated by means of micturition charts, uroflowmetry and cystourethrometry, including electromyography of the periurethral sphincter in females and the bulbocavernosus muscle in males. After 6 weeks on terodiline 25 mg twice a day, the volume per voluntary micturition increased 23 per cent. The number of incontinence episodes decreased. Bladder volume at first urge increased 55 per cent, the maximum cystometric capacity increased 52 per cent, and the detrusor pressure of the first involuntary contraction decreased 27 per cent. The number of voluntary micturitions and voided volume per 24-hour, maximum and average flow, residual urine and urethral pressure at first urge remained unaltered. Terodiline is an alternative drug in the treatment of detrusor hyperreflexia. A follow-up investigation indicates that an increase in terodiline dosage may improve the results.
Asynchronous Event-based Cooperative Stereo Matching Using Neuromorphic Silicon Retinas (2015)

Biologically-inspired event-driven silicon retinas, so called dynamic vision sensors (DVS), allow efficient solutions for various visual perception tasks, e.g. surveillance, tracking, or motion detection. Similar to retinal photoreceptors, any perceived light intensity change in the DVS generates an event at the corresponding pixel. The DVS thereby emits a stream of spatiotemporal events to encode visually perceived objects that in contrast to conventional frame-based cameras, is largely free of redundant background information. The DVS offers multiple additional advantages, but requires the development of radically new asynchronous, event-based information processing algorithms. In this paper we present a fully event-based disparity matching algorithm for reliable 3D depth perception using a dynamic cooperative neural network. The interaction between cooperative cells applies cross-disparity uniqueness-constraints and within-disparity continuity-constraints, to asynchronously extract disparity for each new event, without any need of buffering individual events. We have investigated the algorithm’s performance in several experiments; our results demonstrate smooth disparity maps computed in a purely event-based manner, even in the scenes with temporally-overlapping stimuli.
Epidermal growth factor receptor signaling impairs the antiviral activity of interferon-alpha (2013)

Our results support a model where inhibition of EGFR signaling impairs STAT3 phosphorylation, leading to enhanced IRG expression and antiviral activity. These data uncover a novel role of EGFR signaling in the antiviral activity of IFN-α and open new avenues of improving the efficacy of IFN-α-based antiviral therapies.
Regression analysis of the effect of full and partial lactation on post-partum amenorrhoea in lower middle class Indian females. (1997)

This study presents a simple regression analysis of the impact of full and partial breast feeding on post-partum amenorrhoea (PPA) in lower middle class Indian women. The study has been done on a sample of hospital based data collected in 1992. The analysis shows a highly significant correlation. Further, the impact of lactation on PPA was notably less in case with partial breast feeding as compared to those with full breast feeding.
HEAO-1 - Low energy X-ray observations of clusters of galaxies (1979)

Results are reported for HEAO 1 low-energy X-ray observations of the Perseus and Virgo clusters of galaxies. The best-fit spectrum for the Perseus cluster indicates thermal bremsstrahlung from a plasma at a temperature of 20 + or - 10 million K, with an absorbing hydrogen column of 2 + or - 1 x 10 to the 21st per sq cm. The best-fit thermal-bremsstrahlung model for the Virgo cluster is obtained for a line centered at 1.15 keV, which is the expected position of the iron line complex at a temperature of 40 million K. An iron abundance of 3.1 (+7, -2.3) x 10 to the -5th relative to hydrogen is determined. This abundance is shown to be within a factor of about 3 of the 'cosmic' value.
Automated low-power technique exploiting multiple supply voltages applied to a media processor (1998)

This paper describes an automated design technique to reduce power by making use of two supply voltages. The technique consists of structure synthesis, placement, and routing. The structure synthesizer clusters the gates off the critical paths so as to supply the reduced voltage to save power. The placement and routing tool assigns either the reduced voltage or the unreduced one to each row so as to minimize the area overhead. The reduced supply, voltage is also exploited in a clock tree to reduce power. Combining these techniques together, we applied it to a media processor chip. The combined technique reduced the power by 47% in random-logic modules and by 73% in the clock tree, while keeping the performance.
Studies Using Leukemia Inhibitory Factor (LIF) Knockout Mice and a LIF Adenoviral Vector Demonstrate a Key Anti-Inflammatory Role for This Cytokine in Cutaneous Inflammation (2001)

Previous work has implicated the cytokine leukemia inhibitory factor (LIF) in cutaneous inflammation, although results have differed as to whether LIF is pro- or anti-inflammatory in this setting. We examined edema, inflammatory cell infiltration, and cytokine responses following CFA injection in the adult mouse footpad. Inflammatory cell infiltration and edema are significantly enhanced when CFA is injected in LIF knockout mice as compared with injection of wild-type littermates. Moreover, local injection of an adenoviral vector encoding LIF suppresses both measures of inflammation. In contrast, injection of an adenoviral vector encoding beta-galactosidase has no discernable effect on inflammation. In addition, comparison of the CFA responses in LIF knockout vs wild-type skin reveals that LIF is an important regulator of IL-1beta, IL-6, IL-7, IL-2Ralpha, and IFN-gamma in cutaneous inflammation. These and our previous data indicate that both endogenous and exogenous LIF are anti-inflammatory in the CFA model and that LIF is a key regulator of the cytokine cascade. The results also indicate that adenoviral gene delivery can be an effective therapeutic approach in this paradigm.
Enzymatic enrichment of arachidonic acid from <i>Mortierella</i> single‐cell oil (1998)

Abstract An attempt was made to enrich arachidonic acid (AA) from Mortierella single‐cell oil, which had an AA content of 25%. The first step involved the hydrolysis of the oil with Pseudomonas sp. lipase. A mixture of 2.5 g oil, 2.5 g water, and 4000 units (U) Pseudomonas lipase was incubated at 40°C for 40 h with stirring at 500 rpm. The hydrolysis was 90% complete after 40 h, and the resulting free fatty acids (FFA) were extracted with n ‐hexane (AA content, 25%; recovery of AA, 91%). The second step involved the selective esterification of the fatty acids with lauryl alcohol and Candida rugosa lipase. A mixture of 3.5 g fatty acids/lauryl alcohol (1:1, mol/mol), 1.5 g water, and 1000 U Candida lipase was incubated at 30°C for 16 h with stirring at 500 rpm. Under these conditions, 55% of the fatty acids were esterified, and the AA content in the FFA fraction was raised to 51% with a 92% yield. The long‐chain saturated fatty acids in the FFA fraction were eliminated as urea adducts. This procedure raised the AA content to 63%. To further elevate the AA content, the fatty acids were esterified again in the same manner with Candida lipase. The repeated esterification raised the AA content to 75% with a recovery of 71% of its initial content.
InfoMirror-agent-based information assistance to drivers (2003)

"InfoMirror" is an ITS (Intelligent Transport Systems) application framework that, provides agent-based information assistance to drivers through car navigation systems or on-board PCs. InfoMirror's use of agents allows flexible information retrieval over the Internet, and incorporates a high-speed event delivery facility that makes real-time information service possible. The goal of the system is to provide up to the minute information and services related to driver needs, such as parking lot vacancy information. Crucial to making this a practical operation is the agent-based ability to access the network while the vehicle is in motion.
Ultrasound synthetic aperture imaging: monostatic approach (1994)

An ultrasound synthetic aperture imaging method based on a monostatic approach was studied experimentally. The proposed synthetic aperture method offers good dynamical resolution along with fast numerical reconstruction. In this study complex object data were recorded coherently in a two-dimensional hologram using a 3.5 MHz single transducer with a fairly wide-angle beam. Image reconstruction which applies the wavefront backward propagation method and the near-field curvature compensation was performed numerically in a microcomputer using the spatial frequency domain. This approach allows an efficient use of the FFT-algorithms. Because of the simple and fast scanning scheme and the efficient reconstruction algorithms the method can be made real-time. The image quality of the proposed method was studied by evaluating the spatial and dynamical resolution in a waterbath and in a typical tissue-mimicking phantom. The lateral as well as the range resolution (-6 dB) were approximately 1 mm in the depth range of 30-100 mm. The dynamical resolution could be improved considerably when the beam width was made narrower. Although it resulted in a slightly reduced spatial resolution this compromise has to be done for better resolution of low-contrast targets such as cysts. The study showed that cysts as small as 2 mm by diameter could be resolved.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Vaccine protection by a triple deletion mutant of simian immunodeficiency virus (1996)

Twelve rhesus monkeys were vaccinated with SIVmac316 delta nef (lacking nef sequences), and 12 were vaccinated with SIVmac239 delta3 (lacking nef, vpr, and upstream sequences in U3). SIVmac316 and SIVmac239 differ by only eight amino acids in the envelope; these changes render SIVmac316 highly competent for replication in macrophages. Seventeen of the animals developed persistent infections with the vaccine viruses. Seven of the 24 vaccinated animals, however, developed infections that were apparently transient in nature. Six of these seven yielded virus from peripheral blood when tested at weeks 2 and/or 3, three of the seven had transient antibody responses, but none of the seven had persisting antibody responses. The 24 monkeys were challenged in groups of four with 10 rhesus monkey infectious doses of wild-type, pathogenic SIVmac251 at weeks 8, 20, and 79 following receipt of vaccine. None of the seven with apparently transient infections with vaccine virus were protected upon subsequent challenge. Analysis of cell-associated viral loads, CD4+ cell counts, and viral gene sequences present in peripheral blood in the remainder of the monkeys following challenge allowed a number of conclusions. (i) There was a trend toward increased protection with length of time of vaccination. (ii) Solid vaccine protection was achieved by 79 weeks with the highly attenuated SIV239 delta3. (iii) Solid long-term protection was achieved in at least two animals in the absence of complete sterilizing immunity. (iv) Genetic backbone appeared to influence protective capacity; animals vaccinated with SIV239 delta3 were better protected than animals receiving SIV316 delta nef. This better protection correlated with increased levels of the replicating vaccine strain. (v) The titer of virus-neutralizing activity in serum on the day of challenge correlated with protection when measured against a primary stock of SIVmac251 but not when measured against a laboratory-passaged stock. The level of binding antibodies to whole virus by enzyme-linked immunosorbent assay also correlated with protection.
Poetica dos restos e reciclagem cultural em producoes culturais antilhanas (2004)

In the coming decades, a massive shift in the aging segment of the population will have major social and economic consequences around the world. One way to offset this increase is to expedite the development of geroprotectors, substances that slow aging, repair age-associated damage and extend healthy lifespan, or healthspan. While over 200 geroprotectors are now reported in model organisms and some are in human use for specific disease indications, the path toward determining whether they affect aging in humans remains obscure. Translation to the clinic is hampered by multiple issues including absence of a common set of criteria to define, select, and classify these substances, given the complexity of the aging process and their enormous diversity in mechanism of action. Translational research efforts would benefit from the formation of a scientific consensus on the following: the definition of 'geroprotector', the selection criteria for geroprotectors, a comprehensive classification system, and an analytical model. Here, we review current approaches to selection and put forth our own suggested selection criteria. Standardizing selection of geroprotectors will streamline discovery and analysis of new candidates, saving time and cost involved in translation to clinic.
MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation (2005)

During exacerbation, increased inflammatory burden coincides with an imbalance of the proteinase MMP-9 and its cognate inhibitor TIMP-1. This may suggest a pathway connecting frequent exacerbations with lung function decline.
Fast VLSI Viterbi Decoder (1986)

Fast Viterbi decoder with fully parallel, pipeline architecture implemented on two VLSI NMOS chips. Decoder used with constraint-length-7, rate-1/2, convolutional error-correcting code widely used by NASA for deepspace telemetry data. With this (7,1/2) code, bit stream contains 2 bits per original data bit, and information about 1 data bit distributed over 7 pairs of bits. Design principles of decoder also applicable to Viterbi codes of other lengths and rates.
[Artificial heart valves: state of the art]. (2003)

In the past major problems with artificial valves occurred partially due to the absence of a specific legislation in Belgium. In order to prevent some of those incidents new heart valve prosthesis need to be evaluated by specific tests before being allowed to appear on the Belgian market. Done by: in the following order 1. In vitro testing. At least three samples will be tested in vitro (in the aortic and in the mitral position) in a pulse-duplicator system under static and dynamic conditions. Results of durability testing over long period of time will not be repeated if provided by the companies. 2. Preclinical in vivo testing. Using an experimental animal model. Three different prostheses implanted in an international approved animal model for a minimum period of 5 months. After explanation the valves will be examined (macroscopically, radiographically and pathologically) and compared to the standard prostheses results. 3. Clinical testing. Initially done in heart centers with a large experience of heart valve operations. A minimum of 20 valves, divided over at least 2 centers, will be evaluated over a minimum period of 1 year with strict follow up and report of all complications. Long-term studies will give even more information. 4. Evaluation of the tests. All results will be screened by experts of the Evaluation Committee for Medical Implants (in office since 04/04/2002). If positive the valves will be admitted on the Belgian market to be provided with a fair reimbursement price.
Simul 5 – Free dynamic simulator of electrophoresis (2006)

We introduce the mathematical model of electromigration of electrolytes in free solution together with free software Simul, version 5, designed for simulation of electrophoresis. The mathematical model is based on principles of mass conservation, acid-base equilibria, and electroneutrality. It accounts for any number of multivalent electrolytes or ampholytes and yields a complete picture about dynamics of electromigration and diffusion in the separation channel. Additionally, the model accounts for the influence of ionic strength on ionic mobilities and electrolyte activities. The typical use of Simul is: inspection of system peaks (zones), stacking and preconcentrating analytes, resonance phenomena, and optimization of separation conditions, in either CZE, ITP, or IEF.
Use of a Mini-Transposon to Study Chondroitinase Activity Associated with<i>Edwardsiella ictaluri</i> (1996)

Edwardsiella ictaluri, the etiological agent of enteric septicemia of catfish (ESC), is the leading cause of bacterial disease in commercially raised channel catfish Ictalurus punctatus. Little work has been conducted at a genotypic level to determine potential virulence characteristics, but the production of chondroitin sulfatase is a suspected virulence factor. Using transpositional mutagenesis, we created stable E. ictaluri mutants that are deficient in chondroitinase activity. Channel catfish were challenged by injection with E. ictaluri transposon mutant MI15. None of the catfish challenged with the mutant died or showed signs of ESC. These fish were held for 2 weeks and then challenged by injection with the known virulent parent strain of E. ictaluri. The challenged naive control fish showed clinical signs of and a mortality rate consistent with ESC, whereas catfish that had been injected with MI15 prior to challenge with the parent strain were resistant to disease. This work represents a preliminary study to suggest a possible role of chondroitin sulfatase activity in the virulence of E. ictaluri.
Analysis of Protein–Protein Interactions Using Bioluminescence Resonance Energy Transfer (2009)

Knowledge of how and when proteins interact in living cells is fundamental to our understanding of cellular biology, and bioluminescence resonance energy transfer (BRET) provides an increasingly popular mechanism for studying these interactions in real time. The technique utilises heterologously expressed fusion proteins linking a bioluminescent donor or complementary acceptor fluorophore to proteins of interest. Resonance energy transfer between these fusion proteins is then detected when they are in close proximity, indicative of association either directly or as part of a complex. BRET is particularly useful for real-time monitoring of ligand-modulated interactions as dynamic changes in protein complex assembly can be observed in a live cell environment.
Techniques for Information Extraction from the Surface EMG Signalhigh‐Density Surface EMG (2016)

This chapter deals with the information that can be extracted from images obtained when electrode grids are applied to the skin above muscles with different architectures. The interpretation of these images, and therefore the information obtainable, depends on the muscle architecture and fiber arrangement. The action potentials propagating along muscle fibers generate electric fields in the surrounding conductive medium. The chapter deals with the surface EMG instantaneous images, with the feature images, and with the spatiotemporal images. It provides examples on the information that may be obtained from high-density surface EMG (HD-EMGs) detected from muscles with pinnate architecture. Two main fields of research application of HDsEMG may be identified such as surface EMG imaging and surface EMG decomposition. From the clinical point of view, the expected developments concern more extensive applications in biofeedback and monitoring of the neuromuscular system for prevention purposes and automatic detection of the innervation zone.
Tuning in to the Voices: A Multisite fMRI Study of Auditory Hallucinations (2008)

Although "voices" are the anticipated sensory experience, it appears that even primary auditory cortex is "turned on" and "tuned in" to process internal acoustic information at the cost of processing external sounds. Although this study was not designed to probe cortical competition for auditory resources, we were able to take advantage of the data and find significant effects, perhaps because of the power afforded by such a large sample.