gebhart/patrepeval huggingface dataset:
Novel Steroid Receptor Phyto-Modulator Compound A Inhibits Growth and Survival of Prostate Cancer Cells (2008)

Androgen receptor (AR)- and glucocorticoid receptor (GR)- mediated signaling play opposite roles in prostate tumorigenesis: AR promotes prostate carcinoma (PC) development, whereas GR acts as a tumor suppressor. Compound A (CpdA) is a stable analogue of an aziridine precursor from the African shrub Salsola tuberculatiformis Botschantzev. It was shown recently that, in model cells, CpdA inhibits AR function and strongly enhances anti-inflammatory function of GR. We determined the effects of CpdA in prostate cells with different AR/GR status: (a) RWPE-1 cells (AR(low)/GR(low)), (b) PC3 and DU145 cells (GR(+)/AR(-)), (c) LNCaP cells (GR(-)/AR(+)), and (d) LNCaP-GR cells expressing both receptors. Similar to steroid hormones, CpdA induces nuclear translocation of both receptors in prostate cells. Despite this, CpdA inhibits DNA-binding and transactivation potential of AR. In addition, CpdA inhibits GR-mediated transactivation but induces GR transrepression via inhibition of several transcription factors, including nuclear factor-kappaB, AP-1, Ets-1, Elk-1, SRF, CRE/ATF, and NFATc. CpdA strongly decreases growth and induces caspase-dependent apoptosis in highly malignant PC3 and DU145 cells and in other AR/GR-expressing PC cells. The cytostatic effect of CpdA is receptor dependent: down-regulation of GR or AR expression drastically attenuates CpdA-induced PC cell growth inhibition. Finally, virtual docking analysis indicates that CpdA shares binding cavities in AR and GR ligand-binding domains with corresponding hormones and forms hydrogen bonds (H-bond) with the same amino acids that are involved in H-bond formation during steroid binding. Overall, our data suggest that CpdA is a unique dual-target steroid receptor modulator that has a high potential for PC therapy.
The role of directory services in network management (1992)

In this paper, the potential role and feasibility of the X.500 Directory Service within the CORDS management services is studied. A simple network monitoring application was adapted to use a prototype X.500 Directory Service for (1) device information, (2) application information, and (3) for compiling summary information on network load. This study is a first step towards the understanding of the possible role of the Directory Service in the management of distributed systems and applications. This work provides an initial feasibility study whose results suggest that the X.500 Directory Service can be used for the storage and retrieval of management information in the management framework. The results also suggest that the Directory Service can be used without it being the bottleneck in certain management operations.
Influence of polymer coating on the low-temperature photoluminescence properties of ZnO nanowires (2008)

We report on low temperature photoluminescence studies of ZnO nanowires embedded in different polymers. Comparing the spectra of as-grown and embedded ZnO nanowires, we find a decrease of the deep-level emission and an increase of the near band-edge emission after the embedding process. The near band-edge emission of the embedded ZnO nanowires is dominated by a surface exciton band. The observed effects are independent of the selected polymer. The decrease of the deep-level emission scales with the balling abilities of the different polymers. We propose a model to explain the spectral changes.
Email marketing: permission to pester (2003)

Email marketing is increasingly being recognised as an effective Internet marketing tool.Our paper reviews the email marketing literature, and compares email marketing to other forms of direct and Internet marketing, identifying its key advantages.In the light of the growth of unsolicited email or 'spam', the literature highlights the importance of obtaining recipients' permission.The literature on permission marketing focuses on the nature of permission; there is little empirical research of consumer attitudes.This study extends research in this area by exploring consumer attitudes to a permission marketing email campaign and identifying success factors.In order to explore reactions to email marketing respondents were asked to register at a music website for a customised email newsletter.After two weeks an email questionnaire was sent to respondents.Despite the considerable shortcomings of the particular campaign, nearly a third of our respondents bought from the website and 41 per cent forwarded emails to their friends.This reflects the potential of this new Internet marketing tool.
Lung Deposition and Efficiency of Nebulized Amikacin during <i>Escherichia coli</i> Pneumonia in Ventilated Piglets (2002)

Lung tissue deposition and antibacterial efficiency of nebulized and intravenous amikacin (AMK) were compared in anesthetized and ventilated piglets suffering from a bronchopneumonia produced by the intrabronchial inoculation of Escherichia coli. AMK was administered 24 hours after the inoculation either through an ultrasonic nebulizer (45 mg x kg-1, n = 10) or by intravenous infusion (15 mg x kg-1, n = 8). Piglets were killed 1 hour after a second AMK administration performed 24 hours after the first one, and lung tissue concentrations of AMK and lung bacterial burden were assessed on multiple lung specimens. The amount of nebulized AMK reaching the tracheobronchial tree represented 38 +/- 6% of the initial nebulizer AMK charge. After nebulization, AMK lung tissue concentrations were 3- to 30-fold higher than after intravenous administration and were influenced by the severity of lung lesions: 188 +/- 175 microg x g-1 in lung segments with mild bronchopneumonia versus 40 +/- 65 microg x g-1 in lung segments with severe bronchopneumonia (p < 0.01). Lung bacterial burden was significantly lower in the aerosol group than in the intravenous group (median = 0 colony forming units. g-1 versus median = 5 x 10(2) colony forming units x g-1, p < 0.001). In conclusion, the deposition of AMK in infected lung parenchyma and the efficiency of bacterial killing were greater after nebulization than after intravenous administration.
Enhanced Constellation Rearrangement for HARQ with Symbol Combining (2009)

A new signal constellation rearrangement for HARQ method is presented in this paper, where symbol-combining mappings are used for retransmission and at the receiver, the symbol combination is implemented before demodulation, and then the combined signal is demodulated with a new constellation. The new constellation has the larger minimum Euclidean distance and the complexity is reduced for its less constellation points. Simulation results show that the proposed method outperforms conventional HARQ constellation rearrangement.
The classical equation of state of gaseous helium, neon and argon (1938)

Abstract The deviations from the equation of state for perfect gases which are observed in all known gases result from the interactions of their constituent atoms or molecules. The excess pressures observed at all but the lowest temperatures show that the dominating factor is the strong repulsion between atoms at close renge, due to the interpentration of complete electron shells. Little is known about these repulsions, and that is readily summarized. Between atoms with spherically symmetrical distributions it is likely that the repulsive potential is accurately represented by a function P(r)e-r/p, (1) Where r is separation of the atomic nuclei and P(r) a polynomial in r. Quantum theoretical calculations made by Slater (1928) for helium atoms (with a closed shell of two electrons) and by Bleick and Mayer (1934) for neon atoms (with a closed shell of eight electrons) show that an adequate expression may sometimes be obtained if the polynomial is replaced by a constant. Some confirmation of this (though over a very restricted range of r) is given by Born and Mayer (1932) and Huggins (1937), whose work on ionic cubic crystals shows that their elastic properties are admirably correlated when the repulsive potential of two ions of rare gas type is represented by an exponential function be-r/p, with a range of about one atomic diameter.
Carbothermal synthesis of silicon carbide (1985)

Silicon carbide powders were synthesized from various silica and carbon sources by a carbothermal reduction process at temperatures between 1500 and 1600/sup 0/C. The silica sources were fumed silica, methyltrimethoxysilane, and microcrystalline quartz. The carbon sources were petroleum pitch, phenolic resin, sucrose, and carbon black. Submicron SiC powders were synthesized. Their morphologies included equiaxed loosely-bound agglomerates, equiaxed hard-shell agglomerates, and whiskers. Morphology changed with the furnace atmosphere (argon, nitrogen, or nitrogen-4% hydrogen). The best sintering was observed in SiC derived from the fumed-silica-pitch and fumed-silica-sucrose precursors. The poorest sintering was observed in SiC derived from microcrystalline quartz and carbon black. 11 refs., 16 figs., 10 tabs.
Long-term high-resolution imaging and culture of C. elegans in chip-gel hybrid microfluidic device for developmental studies (2010)

Developmental studies in multicellular model organisms such as Caernohabditis elegans rely extensively on the ability to cultivate and image animals repeatedly at the cell or subcellular level. However, standard high-resolution imaging techniques require the use of anaesthetics for immobilization, and may have undesirable side effects on development. Thus such techniques are not ideal in allowing the same animals to grow and be imaged throughout development to observe specific developmental processes. In this paper, we present a microfluidic system designed to overcome these difficulties. The system allows for long-term culture of C. elegans starting at L1 larval stage and repeated high-resolution imaging at physiological temperatures without using anaesthetics. We use a commercially available biocompatible polymer, Pluronic F127 for immobilization; this polymer is capable of a reversible thermo-sensitive sol-gel transition within approximately 2 degrees C, which is well-controlled in the microfluidic chip. The gel phase is sufficient to immobilize the animals. While animals are not imaged, they are cultured in individual chambers in media containing nutrients required for development. We show here that this method facilitates time-lapse studies of single animals at high-resolution and lends itself to live imaging experiments on developmental processes and dynamic events.
Verification flow optimization using an automatic coverage driven testing policy (2006)

SystemC language as well as the verification library going with (SCV), provides a rich set of features for dynamic control and parameterization of the constraints applied to a constrained-random stimulus generator. Besides, the property specification language (PSL) offers facilities for gathering and inspecting functional coverage information. This paper examines how SCV stimulus constraints can be modified dynamically using functional PSL coverage data, with the aim of avoiding the redundancy of stimulus within the regression test suite. In so doing we allow reducing simulation runtime needed to meet planned functional coverage
Robust statistics in shape fitting (2003)

The concept of robustness in statistics is examined. Starting from the concepts of the breakdown point and equivariance properties of an estimator, the desired equivariance properties for shape fitting are defined, and high breakdown point methods with these properties are found.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Actinomycètes parasites de champignons : étude des espèces, spécificité de l'action parasitaire au genre <i>Fusarium</i> et antagonisme dans le sol envers <i>Fusarium oxysporum</i> f.sp. <i>albedinis</i> (Killian et Maire) Gordon (1987)

A study of two actinomycetes which are parasitic on fungi confirmed that one strain belongs to Nocardiopsis dassonvillei and the other to Streptomyces alni. Although both belong to different genera, they are physiologically related. A study of their parasitic action on numerous species in different genera of fungi revealed a specific mode of action on the genus Fusarium. In an autoclaved palm-grove soil, both actinomycetes strongly reduced propagule populations of Fusarium oxysporum f. sp. albedinis, a pathogen of date palm. This action was less pronounced in the same nonautoclaved soil, where the antagonism of actinomycetes was extenuated by the presence of other soil microorganisms. However, both N. dassonvillei and particularly S. alni decrease the population of F. oxysporum f. sp. albedinis without affecting the number of spores from other soil fungi.
An encrypted image editing scheme based on homomorphic encryption (2015)

There are lots of online image applications which provide image editor services for users. As the plain image may disclose privacy, this paper proposed an encrypted image editing scheme based on homomorphic encryption to make the service be able to process the encrypted image. To achieve this, firstly, a homomorphic encryption scheme was constructed for encrypting the pixels of image. Then, after translating the traditional image editing methods into the operations on encrypted pixels, the encrypted image can be edited homomorphically. The experiments show that our scheme is correct, secure and efficient enough to be used in practical applications.
Abundance of Intrinsic Disorder in Protein Associated with Cardiovascular Disease (2006)

Evidence that many protein regions and even entire proteins lacking stable tertiary and/or secondary structure in solution (i.e., intrinsically disordered proteins) might be involved in protein-protein interactions, regulation, recognition, and signal transduction is rapidly accumulating. These signaling proteins play a crucial role in the development of several pathological conditions, including cancer. To test a hypothesis that intrinsic disorder is also abundant in cardiovascular disease (CVD), a data set of 487 CVD-related proteins was extracted from SWISS-PROT. CVD-related proteins are depleted in major order-promoting residues (Trp, Phe, Tyr, Ile, and Val) and enriched in some disorder-promoting residues (Arg, Gln, Ser, Pro, and Glu). The application of a neural network predictor of natural disordered regions (PONDR VL-XT) together with cumulative distribution function (CDF) analysis, charge-hydropathy plot (CH plot) analysis, and alpha-helical molecular recognition feature (alpha-MoRF) indicator revealed that CVD-related proteins are enriched in intrinsic disorder. In fact, the percentage of proteins with 30 or more consecutive residues predicted by PONDR VL-XT to be disordered was 57 +/- 4% for CVD-associated proteins. This value is close that described earlier for signaling proteins (66 +/- 6%) and is significantly larger than the content of intrinsic disorder in eukaryotic proteins from SWISS-PROT (47 +/- 4%) and in nonhomologous protein segments with a well-defined three-dimensional structure (13 +/- 4%). Furthermore, CDF and CH-plot analyses revealed that 120 and 36 CVD-related proteins, respectively, are wholly disordered. This high level of intrinsic disorder could be important for the function of CVD-related proteins and for the control and regulation of processes associated with cardiovascular disease. In agreement with this hypothesis, 198 alpha-MoRFs were predicted in 101 proteins from the CVD data set. A comparison of disorder predictions with the experimental structural and functional data for a subset of the CVD-associated proteins indicated good agreement between predictions and observations. Thus, our data suggest that intrinsically disordered proteins might play key roles in cardiovascular disease.
Novel 20-MW downhill conveyor system using three-level converters (2002)

This paper presents a very new drive system used to transport ore from the mine down to the concentrator plant in the copper mine "Los Pelambres". Eight 2500-kW motors are driven by three-level inverters with gate-turn-off thyristors (GTOs). A three-level active front end is used at the input side of each inverter. A GTO chopper is used to provide controlled electrical braking in case of line loss. The paper presents the requirements and alternatives for the drive system and the control strategies for the converters and the belt. A novel application of the selective harmonic elimination method is used to reduce the input current harmonics. Special attention is dedicated to the interaction with the electrical network. The most relevant features of the system are: (1) fuseless operation; (2) adjustable power factor; (3) reduced input current harmonics; (4) smooth transition between motoring and regenerating modes; and (5) 15 MW of regenerated power with more than six months of successful operation.
Promoter mapping of the mouse Tcp10bt gene in transgenic mice identifies essential male germ cell regulatory sequences (1996)

Transgenic mice were generated to localize essential promoter elements in the mouse testis-expressed Tcp-10 genes. These genes are expressed exclusively in male germ cells, and exhibit a diffuse range of transcriptional start sites, possibly due to the absence of a TATA box. A series of transgene constructs containing different amounts of 5′ flanking DNA revealed that all sequences necessary for appropriate temporal and tissue-specific transcription of Tcp-10 reside between positions −1 to −973. All transgenic animals containing these sequences expressed a chimeric transgene at high levels, in a pattern that paralleled the endogenous genes. These experiments further defined a 227 bp fragment from −746 to −973 that was absolutely essential for expression. In a gel-shift assay, this 227-bp fragment bound nuclear protein from testis, but not other tissues, to yield two retarded bands. Sequence analysis of this fragment revealed a half-site for the AP-2 transcription factor recognition sequence. Gel shift assays using native or mutant oligonucleotides demonstrated that the putative AP-2 recognition sequence was essential for generating the retarded bands. Since the binding activity is testis-specific, but AP-2 expression is not exclusive to male germ cells, it is possible that transcription of Tcp-10 requires interaction between AP-2 and a germ cell-specific transcription factor. © 1996 Wiley-Liss, Inc.
Organocatalytic C–H/C–H′ Cross-Biaryl Coupling: C-Selective Arylation of Sulfonanilides with Aromatic Hydrocarbons (2013)

The hypervalent iodine-mediated C-C selective coupling of N-methanesulfonyl anilides with aromatic hydrocarbons has been developed. The first organocatalytic oxidative cross-biaryl-coupling was achieved by the catalyst control in defining specific 2,2'-diiodobiphenyls for the direct C-C bond formations.
Increased Acid Sphingomyelinase Activity in Peripheral Blood Cells of Acutely Intoxicated Patients With Alcohol Dependence (2009)

Alcohol-induced activation of ASM occurs in human subjects and might be responsible for deleterious effects of ethanol intoxication. Chronic alcohol abuse may induce deregulation of sphingomyelin metabolism in general, and this impairment may cause side effects during withdrawal from alcohol.
Ultra-compact grating-based monolithic optical pulse compressor for laser amplifier systems (2016)

A compact and robust grating-based monolithic optical pulse compressor is proposed. By integrating diffraction gratings onto opposite surfaces of a solid fused-silica block whose index of refraction is larger than that of air, one reduces the effective physical optical path length and hence the requisite longitudinal separation between the gratings. Furthermore, appropriate distributed Bragg reflectors coated on the two transverse surfaces of the block are used to fold the physical distance diffracted light travels between the gratings; this is accomplished by multiple reflections within the block before the beam impinges on the second grating. Ultimately, the combined effects of the Bragg reflectors and the optically dense solid block contribute to reducing the physical volume of the compressor. Two approaches for analyzing the function of the proposed compressor are presented. Parameters from a conventional compressor are used to validate the method for a comparative calculation of the volumes of the new and conventional compressor system.
At Century's End (1999)

Journal Article At Century's End Get access Linda B. Miller Linda B. Miller Search for other works by this author on: Oxford Academic Google Scholar International Studies Review, Volume 1, Issue 3, Fall 1999, Page xv, https://doi.org/10.1111/1521-9488.00161 Published: 17 December 2002
ATM network and VBR video source: data structure and statistical analysis of an implemented hybrid DCT broadcast video encoder (2002)

The arrangement of data in a variable bit rate (VBR) video codec, making it suitable for the transmission over ATM (asynchronous transfer mode) networks, is addressed. Attention is focused on two aspects specifically belonging to the ATM environment: the impairment due to the loss of ATM data cells and the statistical analysis of a real VBR video source. A particular implementation of a hybrid DCT (discrete cosine transform) broadcast video codec, which adheres to the recent specifications proposed by the European Telecommunications Standards Institute, is addressed. In order to optimize the performance with respect to cell losses, a specific solution based on the concept of organizing data into video packets is explored. The statistical characteristics of the available VBR video source are investigated, using a real-time acquisition system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
MPEG-2 Video Services over Packet Networks: Joint Effect of Encoding Rate and Data Loss on User-Oriented QoS (1998)

We address the problem of video quality prediction and control for high resolution video transmitted over lossy packet networks. We analyze how the user-perceived quality is related to the average encoding bitrate for VBR MPEG-2 video. We then show why simple distortion metrics (e.g., PSNR) may lead to inconsistent interpretations. Furthermore, for a given coder setup, we analyze the effect of packet loss on the user-level quality. We then demonstrate that, when jointly studying the impact of coding bit rate and packet loss, the reachable quality is upperbound and exhibits one optimal coding rate for a given packet loss ratio. This paper is organized as follows: In Sec. 2, we introduce the MPEG-2 video and system standards. We briefly describe the impact of data loss on the reconstructed video sequence. Finally, useful video quality metrics are described, among them is the MPQM which is based on a vision model. The study of the impact of MPEG-2 rate and data loss on quality is the subject of Sec. 3. Section 4 deals with the joint impact analysis of both MPEG-2 rate and data loss on video quality. Concluding remarks are given