gebhart/patrepeval huggingface dataset:
Activation of MAP kinase by the LHRH receptor through a PKC-dependent pertussis toxin-sensitive mechanism (1995)

Conference Article| February 01 1995 Activation of MAP kinase by the LHRH receptor through a PKC-dependent pertussis toxin-sensitive mechanism PAULINE SIM; PAULINE SIM 1MRC Brain Metabolism Unit, 1 George Square, Edinburgh EH8 9JZ, UK Search for other works by this author on: This Site PubMed Google Scholar RORY MITCHELL RORY MITCHELL 1MRC Brain Metabolism Unit, 1 George Square, Edinburgh EH8 9JZ, UK Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1995) 23 (1): 144S. https://doi.org/10.1042/bst023144s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation PAULINE SIM, RORY MITCHELL; Activation of MAP kinase by the LHRH receptor through a PKC-dependent pertussis toxin-sensitive mechanism. Biochem Soc Trans 1 February 1995; 23 (1): 144S. doi: https://doi.org/10.1042/bst023144s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1995 Biochemical Society1995 Article PDF first page preview Close Modal You do not currently have access to this content.
An efficient new hybrid cascaded H-bridge inverter for photovoltaic system (2014)

This paper deals with electricity from photovoltaic system for cascaded multilevel inverter. The general function of multilevel inverter is to synthesis desired voltage from solar source. This inverter has advantageous of industrial applications. The use of converters will increase losses and cost in conventional methods. The proposed nine level multilevel inverter with solar energy using Pulse Width Modulation Technique (PWM) of providing high switching frequency will highly reduce harmonics.
Luminescence distribution in the multi-quantum well region of III-nitride light emitting diodes (2017)

We investigate the luminescence distribution in the multi quantum well (MQW) region of polar III-nitride light emitting diodes (LED) operating in the blue spectral range by means of carrier transport simulations. The MQW region is modeled with an equivalent circuit. It is demonstrated that the MQW barriers primarily aﬀect the hole transport. The electron scattering from continuum to bound quantum well states has a major impact on the electron transport. A nearly uniform luminescence distribution in the MQW region is achieved through a re-distribution of the luminescence from the n-side to the p-side QW with increasing current. We show that the re-distribution is seen through a decrease of the ideality factor in the MQW region and promoted by the asymmetry of the electron and hole transport.
A general matrix operator for linear boundary value problems in slip‐line field theory (1985)

Abstract A general matrix operator is established for solving linear boundary value problems in slip‐line field theory. The operator will enable a wider class of problems to be solved than were previously possible with the matrix slip‐line field technique. As an illustration, a range of solutions are generated involving the previously intractable Coulomb friction boundary condition.
The design and characteristic study of a 3-dimensional piezoelectric nano-positioner (2010)

This paper presents a mechanical design method of “thin column group” guidance and multi-actuator parallel mechanism for three degrees of freedom translations, since multi-actuator parallel mechanism is utilized to implement planar motions which are general requirements for the nano-positioner. The traveling range of this nano-positioner is 5 μm in the X-, Y-directions and in the vertical direction. The three-dimensional nano-positioner has several advantages such as low-cost, high-precision, and can be applied to the assembly, processing, bio-tech and medicine detection and semi-conduct industry. In the feedback controller, we choose MATLAB/Simulink, Real-Time Workshop, a software widely used by the academic community, as tools to study rapid controller prototyping. The parameters are controlled based on proportion-integral control law that is easily used and has a good performance.
SmartGuard: An autonomous robotic system for inspecting substation equipment (2011)

Abstract Substation equipment inspection is necessary for the power industry. With the dramatic increase in the number of substations, unmanned substations are required by the industry. This paper presents SmartGuard, a completely autonomous robotic system that can inspect substation equipment. SmartGuard consists of a robot and a data center. The robot can patrol in a substation and inspect equipment with a visible‐light camera and an infrared thermograph. The acquired images and temperature information are analyzed by the data center. The data center can fuse infrared and visible‐light images and find abnormal hot spots and abnormal appearance. There are 13 SmartGuards currently serving 12 substations, some of which have been working for more than 2 years. The feedback from the field shows that SmartGuard significantly improves the efficiency and reliability of substation inspection. © 2011 Wiley Periodicals, Inc.
Quantifying estrogen metabolism: an evaluation of the reproducibility and validity of enzyme immunoassays for 2-hydroxyestrone and 16alpha-hydroxyestrone in urine. (1997)

Rapid and simple enzyme immunoassays (EIAs) were recently developed to measure 2-hydroxyestrone and 16alpha-hydroxyestrone in unextracted urine. The balance between these competing estrogen metabolism pathways may serve as a biomarker of breast cancer risk. Before testing these assays in epidemiologic studies, we evaluated their reproducibility, and validity relative to gas chromatography-mass spectroscopy (GC-MS). Overnight 12-hr urine collections from five midfollicular premenopausal women, five midluteal premenopausal women, and five postmenopausal women were aliquoted and stored at -70 degrees C. Two aliquots from each woman were assayed with the EIAs in a random, blinded order, monthly over 4 months and 1 year later. Reproducibility over 4 months was good for both metabolites in premenopausal women (coefficient of variation = 8-14%) and satisfactory in postmenopausal women (approximately 19%). Reproducibility over 12 months remained good in premenopausal women, but was poor in postmenopausal women, with mean readings increasing 50 to 100%. Wide variation in estrogen metabolite levels enabled a single EIA measurement to characterize individual differences among premenopausal women in midfollicular (intraclass correlation coefficient = 98-99%) and midluteal phase (85-91%). A narrower range in metabolite levels among postmenopausal women reduced discrimination (78-82%). The correlation between EIA and GC-MS measurement was excellent for both metabolites (r>0.9), except for 2-hydroxyestrone in postmenopausal women (r=0.6). Analysis of absolute agreement suggested that both EIAs were less sensitive than GC-MS, and each detected nonspecific background. The low concentration of estrogen metabolites in urine from postmenopausal women may explain the problems with reproducibility and validity in this menstrual group. Accordingly, more sensitive EIAs have been developed and are now being evaluated.
MOS-PN Hybrid Device With Minimum Dark Current for Sensitive Digital Photodetection (2014)

This letter presents a CMOS-compatible photodetector displaying direct light-to-time conversion and intrinsic charge integration with a very low dark current. This device is particularly adapted for applications requiring high sensitivity such as bioluminescence detection. The effects of the physical structure, the process parameters, and the bias conditions on the device are discussed with the support of TCAD simulations and experimental measurements. The photodetector and its readout circuit are designed and implemented in standard 0.18-μm CMOS process. The experimental study shows promising tunability and sensitivity characteristics.
The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia (2017)

T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy that results from the transformation of immature T-cell progenitors. Aberrant cell growth and proliferation in T-ALL lymphoblasts are sustained by activation of strong oncogenic drivers promoting cell anabolism and cell cycle progression. Oncogenic NOTCH signaling, which is activated in more than 65% of T-ALL patients by activating mutations in the <i>NOTCH1</i> gene, has emerged as a major regulator of leukemia cell growth and metabolism. T-ALL <i>NOTCH1</i> mutations result in ligand-independent and sustained NOTCH1-receptor signaling, which translates into activation of a broad transcriptional program dominated by upregulation of genes involved in anabolic pathways. Among these, the <i>MYC</i> oncogene plays a major role in NOTCH1-induced transformation. As result, the oncogenic activity of NOTCH1 in T-ALL is strictly dependent on MYC upregulation, which makes the NOTCH1-MYC regulatory circuit an attractive therapeutic target for the treatment of T-ALL.
Unique fatty acid composition of normal cartilage: discovery of high levels of n‐9 eicosatrienoic acid and low levels of n‐6 polyunsaturated fatty acids (1991)

We report here the finding that normal, young cartilages, in distinction from all other tissues examined, have unusually high levels of n-9 eicosatrienoic (20:3 cis-delta 5,8,11) acid and low levels of n-6 polyunsaturated fatty acids (n-6 PUFA). This pattern is identical to that found in tissues of animals subjected to prolonged depletion of nutritionally essential n-6 polyunsaturated fatty acids (EFA). This apparent deficiency is consistently observed in cartilage of all species so far studied (young chicken, fetal calf, newborn pig, rabbit, and human), even though levels of n-6 PUFA in blood and all other tissues is normal. The n-9 20:3 acid is particularly abundant in phosphatidylethanolamine, phosphatidylinositol, and the free fatty acid fractions from the young cartilage. Several factors appear to contribute to the reduction in n-6 PUFA and the appearance of high levels of the n-9 20:3 acid in cartilage: 1) limited access to nutritional sources of EFA due to the impermeability and avascularity of cartilage, 2) rapid metabolism of n-6 PUFA to prostanoids by chondrocytes, and 3) a unique fatty acid metabolism by cartilage. Evidence is presented that each of these factors contributes. Previously, EFA deficiency has been shown to greatly suppress the inflammatory response of leukocytes and rejection of tissues transplanted into allogeneic recipients. Because eicosanoids, which are derived from EFA, have been implicated in the inflammatory responses associated with arthritic disease, reduction of n-6 PUFA and accumulation of the n-9 20:3 acid in cartilage may be important for maintaining normal cartilage structure.
Keynes as a Classical Economist (1966)

One thing that must be kept in mind throughout the reading of these pages is that Keynes was always a classical economist. Much space will be devoted below to the manner in which he made a significant break with classical doctrine; but as all economists know, it is almost impossible to get rid of early impressions, especially after they have stuck for two decades or more. It was not until Keynes had lived through a few years of the world’s greatest economic catastrophe that he was able to divorce himself from some of the standard doctrines. In this chapter we shall look carefully at the body of economic theory and policy (always so important with Keynes), which was being espoused by Keynes, in order that we may get a clear picture of the development which must have been going on in his own mind up to the early part of the thirties.
Stabilization of Microsatellite Sequences by Variant Repeats in the Yeast <i>Saccharomyces cerevisiae</i> (1997)

We examined the effect of a single variant repeat on the stability of a 51-base pair (bp) microsatellite (poly GT). We found that the insertion stabilizes the microsatellite about fivefold in wild-type strains. The stabilizing effect of the variant base was also observed in strains with mutations in the DNA mismatch repair genes pms1, msh2 and msh3, indicating that this effect does not require a functional DNA mismatch repair system. Most of the microsatellite alterations in the pms1, msh2 and msh3 strains were additions or deletions of single GT repeats, but about half of the alterations in the wild-type and msh6 strains were large (> 8 bp) deletions or additions.
The Batcher-banyan self-routing network: universality and simplification (1988)

It is shown that the Batcher-banyan network performs as a universal self-routing switch when inputs with unassigned destinations are present. This is demonstrated by first proving that banyan networks can realize permutations represented by bitonic sequences, and then noting that the sorted output of the Batcher network can be viewed as a bitonic sequence. Two methods are proposed for reducing the complexity of the Batcher-banyan network. In the first method, one stage of the banyan network is eliminated by assigning proper destination tags to the unassigned inputs. In the second, a self-routing switch based on the binary-radix sorting scheme is shown to be more economical for a small number of lines.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Strategies and Tactics for the Metal‐Directed Synthesis of Rotaxanes, Knots, Catenanes, and Higher Order Links (2011)

More than a quarter of a century after the first metal template synthesis of a [2]catenane in Strasbourg, there now exists a plethora of strategies available for the construction of mechanically bonded and entwined molecular level structures. Catenanes, rotaxanes, knots and Borromean rings have all been successfully accessed by methods in which metal ions play a pivotal role. Originally metal ions were used solely for their coordination chemistry; acting either to gather and position the building blocks such that subsequent reactions generated the interlocked products or by being an integral part of the rings or "stoppers" of the interlocked assembly. Recently the role of the metal has evolved to encompass catalysis: the metal ions not only organize the building blocks in an entwined or threaded arrangement but also actively promote the reaction that covalently captures the interlocked structure. This Review outlines the diverse strategies that currently exist for forming mechanically bonded molecular structures with metal ions and details the tactics that the chemist can utilize for creating cross-over points, maximizing the yield of interlocked over non-interlocked products, and the reactions-of-choice for the covalent capture of threaded and entwined intermediates.
Deep learning for low-dose CT (2017)

Given the potential risk of X-ray radiation to the patient, low-dose CT has attracted a considerable interest in the medical imaging field. Currently, the main stream low-dose CT methods include vendor-specific sinogram domain filtration and iterative reconstruction algorithms, but they need to access raw data whose formats are not transparent to most users. Due to the difficulty of modeling the statistical characteristics in the image domain, the existing methods for directly processing reconstructed images cannot eliminate image noise very well while keeping structural details. Inspired by the idea of deep learning, here we combine the autoencoder, deconvolution network, and shortcut connections into the residual encoder-decoder convolutional neural network (RED-CNN) for low-dose CT imaging. After patch-based training, the proposed RED-CNN achieves a competitive performance relative to the-state-of-art methods. Especially, our method has been favorably evaluated in terms of noise suppression and structural preservation.
Break Azeotropes with Pressure-Sensitive Distillation (1997)

This article will review distillation processes that take advantage of pressure sensitivity. It will only consider minimum-boiling azeotropes because most azeotropes encountered in solvent recycling applications fall into this category. Depending upon whether one or both components need to be isolated, pressure-sensitive distillation can involve either one or two columns.
Cell cycle-regulated repression of B-myb transcription: cooperation of an E2F site with a contiguous corepressor element (1996)

B-myb belongs to a group of cell cycle genes whose transcription is repressed in G0/early G1 through a binding site for the transcription factor E2F. Here, we show that the B-myb repressor element is specifically recognised by heterodimers consisting of DP-1 and E2F-1, E2F-3 or E2F-4. Surprisingly, E2F-mediated repression is dependent on a contiguous corepressor element that resembles the CHR previously established as a corepressor of the CDE in cell cycle genes derepressed in S/G2, such as cyclin A, cdc2 and cdc25C. A factor binding to the B-myb CHR was identified in fractionated HeLa nuclear extract and found to interact with the minor groove, as previously shown by in vivo footprinting for the cyclin A CHR. The B-myb and cdc25C CHRs are related with respect to protein binding but are functionally clearly distinct. Our results support a model where both E2F- and CDE-mediated repression, acting at different stages in the cell cycle, are dependent on promoter-specific CHR elements.
Semiquantitative Study of the EDC/NHS Activation of Acid Terminal Groups at Modified Porous Silicon Surfaces (2009)

Infrared spectroscopy is used to investigate the transformation of carboxyl-terminated alkyl chains immobilized on a surface into succinimidyl ester-terminated chains by reaction with an aqueous solution of N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The acid chains are covalently grafted at the surface of hydrogenated porous silicon whose large specific surface area allows for assessing the activation yield in a semiquantitative way by infrared (IR) spectroscopy and detecting trace amounts of surface products and/or reaction products of small IR cross section. In this way, we rationalize the different reaction paths and optimize the reaction conditions to obtain as pure as possible succinimidyl ester-terminated surfaces. A diagram mapping the surface composition after activation was constructed by systematically varying the solution composition. Results are accounted for by NHS surface adsorption and a kinetic competition between the various EDC-induced surface reactions.
Glutathione Peroxidase-Deficient Mice Are More Susceptible to Neutrophil–Mediated Hepatic Parenchymal Cell Injury During Endotoxemia: Importance of An Intracellular Oxidant Stress (1999)

Neutrophils contribute to hepatocellular injury in a number of acute inflammatory reactions. However, the molecular mechanism of parenchymal cell injury remains controversial. To address the issue of whether or not reactive oxygen species (ROS) are important in the injury process, we used the galactosamine/endotoxin (Gal/ET) model of acute liver failure, which involves a neutrophil-mediated parenchymal cell injury. In C3Heb/FeJ mice, Gal/ET induced a significant increase of hepatic and plasma levels of glutathione disulfide (GSSG), an indicator of oxidant stress, selectively during the neutrophil-mediated injury phase. In glutathione peroxidase-deficient mice (Gpx1(-/-)), Gal/ET or Gal/tumor necrosis factor alpha (TNF-alpha) caused more severe neutrophil-mediated liver injury compared with wild-type animals. However, there was no significant difference in other critical parameters, e.g., activation of the transcription factor, nuclear factor-kappaB (NF-kappaB), and soluble intercellular adhesion molecule-1 (sICAM-1), parenchymal cell apoptosis, and neutrophil sequestration in the liver. Our results suggest that neutrophil-derived ROS are responsible for an intracellular oxidant stress in hepatocytes after Gal/ET treatment. Because of the higher susceptibility of Gpx1(-/-) mice to a neutrophil-mediated injury, we conclude that peroxides generated by neutrophils diffused into hepatocytes and contributed to parenchymal cell death in vivo. Thus, strengthening defense mechanisms against ROS in target cells can attenuate excessive inflammatory injury without affecting host defense reactions.
The Children of the Dream: Postwar Planning for the First Camp of the Children's International Summer Villages Organization. (1995)

Established in the Midwest in the late 1940's by Dr. Doris Allen of the University of Cincinnati, Children's International Summer Villages (CISV) is a worldwide youth organization dedicated to peace and better global understanding. This article focuses on its creation and the ideas behind CISV, plus it documents the organizational work undertaken to open the first international children's summer camp in suburban Cincinnati, Ohio in 1951. Although multiculturalism is a contemporary expression, it can be seen historically that CISV represents a precursor to our current efforts in multicultural education.
Low power/low voltage high speed CMOS differential track and latch comparator with rail-to-rail input (2002)

A new CMOS differential latched comparator suitable for low voltage, low-power application is presented. The circuit consists of constant-gm rail-to-rail common-mode operational transconductance amplifier followed by a regenerative latch in a track and latch configuration to achieve a relatively constant delay. The use of a track and latch minimizes the total number of gain stages required for a given resolution. Potential offset from the constant-g/sub m/ differential input stage, estimated as the main source of offset, can be minimized by proper choice of transistors sizes. Simulation results show that the circuit requires less than 86 /spl mu/A with a supply voltage of 1.65 V in a standard CMOS 0.18 /spl mu/m digital process. The average delay is less than 1 ns and is approximately independent of the common-mode input voltage.
A new DAG scheduling algorithm for heterogeneous platforms (2012)

Efficient task scheduling is one of the key factors for providing high performance on heterogeneous computing systems. However, due to many factors, such as the heterogeneity of such systems, solving efficiently such a problem is becoming a challenging task. In this paper, we address the problem of scheduling directed acyclic graphs (DAGs) on heterogeneous platforms composed of a set of processors grouped in a cluster of clusters (Multi-Clusters). Our main objective here is to develop a new DAG scheduling algorithm taking into account several characteristics of the target platform, including the heterogeneity of both computing powers of processors and communication links. Simulation results, based on both randomly generated graphs and platforms and real configuration based generated platforms, show that the proposed algorithm provides interesting performances and performs better than some well-known existing scheduling algorithms.
Rhetoric and Reality in the Dispute Settlement Movement (1984)

Efforts to demystify and simplify the way disputes are settled in American society seem to have congealed into a nationwide movement within less than a decade: neighborhood justice centers, arbitration, divorce mediation, no-fault auto insurance, do-it-yourself probate, "plain English" land and rental agreements, government ombudsmen, consumer hot lines, community mediation of minor criminal cases. A growth industry, if there ever was one