gebhart/patrepeval huggingface dataset:
Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12- <i>O</i> -Tetradecanoylphorbol-13-Acetate (2015)

In this study, the effects of combining ursolic acid + resveratrol, for possible combined inhibitory effects on skin tumor promotion, were evaluated. Ursolic acid, resveratrol, and the combination of ursolic acid + resveratrol were applied topically prior to 12-O-tetracanoylphorbol-13-acetate (TPA) treatment on mouse skin to examine their effect on TPA-induced signaling pathways, epidermal hyperproliferation, skin inflammation, inflammatory gene expression, and skin tumor promotion. The combination of ursolic acid + resveratrol produced a greater inhibition of TPA-induced epidermal hyperproliferation. The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-κB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds. Ursolic acid + resveratrol also induced a dramatic increase of p-AMPK-α(Thr172). Combined treatment with ursolic acid + resveratrol resulted in a greater inhibition of expression of proinflammatory cytokines, including Il1a, Il1b, and Il22. Furthermore, NF-κB, Egr-1, and AP-1 DNA binding activities after TPA treatment were dramatically decreased by the combination of ursolic acid + resveratrol. Treatment with ursolic acid + resveratrol during skin tumor promotion with TPA produced greater inhibition of tumor multiplicity and tumor size than with either agent alone. Collectively, the greater ability of the combination of ursolic acid + resveratrol to inhibit skin tumor promotion was due to the greater inhibitory effects on growth factor and inflammatory signaling, skin inflammation, and epidermal hyperproliferation induced by TPA treatment.
Beneficial effects of C1 esterase inhibitor in ST-elevation myocardial infarction in patients who underwent surgical reperfusion: a randomised double-blind study (2007)

The inhibition of the classic complement pathway by C1-INH appears to be an effective mean of preserving ischaemic myocardium from reperfusion injury as demonstrated by low serum cTnI levels in C1-INH group. Therefore, the use of C1-INH during CABG as a rescue therapy in STEMI patients is probably an effective treatment to inhibit complement activity and to improve cardiac function and haemodynamic performance without impacting early mortality. Large randomised study should be performed to support our results.
Wobbling Mass Influence on Impact Ground Reaction Forces: A Simulation Model Sensitivity Analysis (2004)

Wobbling mass models have been used to gain insight into joint loading during impacts. This study investigated the sensitivity of a wobbling mass model of landing from a drop to the model's parameters. A 2-D wobbling mass model was developed. Three rigid linked segments designed to represent the skeleton each had a second mass attached to them, via two translational nonlinear spring dampers, representing the soft tissue. Model parameters were systematically varied one at a time and the effect this had on the peak vertical ground reaction force and segment kinematics was examined. Model output showed low sensitivity to most model parameters but was sensitive to the timing of joint torque initiation. Varying the heel pad stiffness in the range of stiffness values reported in the literature had the largest influence on peak vertical ground reaction force. The analysis indicated that the more proximal body segments had a lower influence on peak vertical ground reaction force per unit mass than the segments nearer the contact point. Model simulations were relatively insensitive to variations in the properties of the connection between wobbling masses and the skeleton. If the goal is to examine the effects of wobbling mass on the system, this insensitivity is an advantage, with the proviso that estimates for the other model parameters and joint torque activation timings lie in a realistic range. If precise knowledge about the motion of the wobbling mass is of interest, however, this calls for more experimental work to precisely determine these model parameters.
Alignment of Mesoporous Silica on a Glass Substrate by a Rubbing Method (1999)

Alignment of hexagonal mesoporous silica particles was achieved by a simple rubbing method used for the alignment of liquid crystals on a very thin polyimide film coated on a silica glass substrate. Mesoporous silica was synthesized through the hydrolysis of tetraethoxysilane under acidic conditions in the presence of hexadecyltrimethylammonium chloride. The arrangement of the elongated particles was observed with their long axes parallel to the rubbing direction. The maximum aspect ratio of the particles reached ∼100. Both the elongation and alignment of the particles were not observed on the same substrate without the rubbing treatment. The hexagonal channel orientation was confirmed using in-plane X-ray diffraction and high-resolution scanning electron microscopy. The hexagonal mesoporous structure was retained over calcination in air and the adhesion of the particles onto the substrate was greatly improved.
Aqueous foams stabilized solely by particles (2011)

Foams are dispersions of bubbles in liquids, often water. They are frequently stabilized by surfactant or polymer, but like Pickering emulsions, they can be also stabilized solely by particles. If the particles have a moderate hydrophobicity, the foams can be extremely stable (lifetimes of the order of years). Due to technical preparation difficulties, very few studies can be found in the literature to date. We will discuss the origin of these difficulties. We will also describe experiments using partially hydrophobic fumed silica particles, in which the foam properties were correlated with the properties of spread and adsorbed layers of these particles at the air–water interface. These combined experiments allowed us to define the conditions necessary to stop bubble disproportionation.
Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart failure (2009)

To identify a novel target for the treatment of heart failure, we examined gene expression in the failing heart. Among the genes analyzed, Alox15 encoding the protein 12/15 lipoxygenase (LOX) was markedly up-regulated in heart failure. To determine whether increased expression of 12/15-LOX causes heart failure, we established transgenic mice that overexpressed 12/15-LOX in cardiomyocytes. Echocardiography showed that Alox15 transgenic mice developed systolic dysfunction. Cardiac fibrosis increased in Alox15 transgenic mice with advancing age and was associated with the infiltration of macrophages. Consistent with these observations, cardiac expression of monocyte chemoattractant protein 1 (MCP-1) was up-regulated in Alox15 transgenic mice compared with wild-type mice. Treatment with 12-hydroxy-eicosatetraenoic acid, a major metabolite of 12/15-LOX, increased MCP-1 expression in cardiac fibroblasts and endothelial cells but not in cardiomyocytes. Inhibition of MCP-1 reduced the infiltration of macrophages into the myocardium and prevented both systolic dysfunction and cardiac fibrosis in Alox15 transgenic mice. Likewise, disruption of 12/15-LOX significantly reduced cardiac MCP-1 expression and macrophage infiltration, thereby improving systolic dysfunction induced by chronic pressure overload. Our results suggest that cardiac 12/15-LOX is involved in the development of heart failure and that inhibition of 12/15-LOX could be a novel treatment for this condition.
Joint Learning of Convolutional Neural Networks and Temporally Constrained Metrics for Tracklet Association (2016)

In this paper, we study the challenging problem of multiobject tracking in a complex scene captured by a single camera. Different from the existing tracklet associationbased tracking methods, we propose a novel and efficient way to obtain discriminative appearance-based tracklet affinity models. Our proposed method jointly learns the convolutional neural networks (CNNs) and temporally constrained metrics. In our method, a siamese convolutional neural network (CNN) is first pre-trained on the auxiliary data. Then the siamese CNN and temporally constrained metrics are jointly learned online to construct the appearance-based tracklet affinity models. The proposed method can jointly learn the hierarchical deep features and temporally constrained segment-wise metrics under a unified framework. For reliable association between tracklets, a novel loss function incorporating temporally constrained multi-task learning mechanism is proposed. By employing the proposed method, tracklet association can be accomplished even in challenging situations. Moreover, a largescale dataset with 40 fully annotated sequences is created to facilitate the tracking evaluation. Experimental results on five public datasets and the new large-scale dataset show that our method outperforms several state-of-the-art approaches in multi-object tracking.
Surface kinetic study of ion-induced chemical vapor deposition of copper for focused ion beam applications (1997)

A systematic surface kinetic study of ion-induced chemical vapor deposition (II-CVD) of Cu from Cu(I) hexafluoroacetylacetonate vinyltrimethylsilane was performed using quartz crystal microbalance mass deposition rate measurements, x-ray photoelectron spectroscopy compositional analysis, and laser-induced thermal desorption coverage measurements in a multibeam scattering apparatus. With the above, a phenomenological surface kinetic model describing the adsorption, deposition (both of the desired source metal and of unwanted impurities), byproduct desorption, and sputtering processes involved in II-CVD was formulated. The surface kinetic model predicts the deposition rate, composition, and precursor coverage dependencies in agreement with experimental results.
Cofactor-dependent enzyme catalysis in functionalized ionic solvents (2004)

Functionalized, hydrogen-bonding ionic liquids have been successfully evaluated as media for the performance of cofactor-dependent enzyme catalysed oxidations; the effects of incorporating hydroxyl groups into both the cation and anion have been studied and the dependence of activity upon water content has been evaluated.
Follicular lymphoma tumor–infiltrating T-helper (TH) cells have the same polyfunctional potential as normal nodal TH cells despite skewed differentiation (2011)

The follicular lymphoma (FL) T-cell microenvironment plays a critical role in the biology of this disease. We therefore determined the lineage, differentiation state, and functional potential of FL-infiltrating CD4(+) T-helper cells (T(H)) compared with reactive and normal lymph node (NLN) T(H) cells. Relative to NLNs, FL cells have decreased proportions of naive and central memory but increased proportions of effector memory T(H) cells. We further show differences in the distribution and anatomical localization of CXCR5(+) T(H) populations that, on the basis of transcription factor analysis, include both regulatory and follicular helper T cells. On Staphylococcus enterotoxin-B stimulation, which stimulates T cells through the T-cell receptor, requires no processing by APCs, and can overcome regulator T cell-mediated suppression, the proportion of uncommitted primed precursor cells, as well as T(H)2 and T(H)17 cells is higher in FL cells than in reactive lymph nodes or NLNs. However, the proportion of T(H)1 and polyfunctional T(H) cells (producing multiple cytokines simultaneously) is similar in FL cells and NLNs. These data suggest that, although T(H)-cell differentiation in FL is skewed compared with NLNs, FL T(H) cells should have the same intrinsic ability to elicit antitumor effector responses as NLN T(H) cells when tumor suppressive mechanisms are attenuated.
The Role of Faculty Advisors in the Success of Psi Chi Chapters: Leadership Characteristics and Their Relation With Student Organization Success (2021)

Leaders of a student organization may have a strong impact on the success of the chapter they lead. The current research study examined leadership qualities of Psi Chi Faculty Advisors, leaders in a Psychology honors society, and how those qualities affected the activity, involvement, and satisfaction of members within Psi Chi. In order to assess these variables, a national online survey was sent out to Psi Chi student leaders asking them to evaluate their Faculty Advisor's leadership characteristics in addition to their Psi Chi chapter. Two-hundred and eighty-five surveys were completed and returned. Results showed a significant positive correlation between Psi Chi Faculty Advisor leadership scores and student satisfaction (r=.436, p< .01). Results also show a significant positive correlation between Faculty Advisor leadership scores and chapter activity (r=.190, p
A high-performance electrochemical supercapacitor based on a polyaniline/reduced graphene oxide electrode and a copper(<scp>ii</scp>) ion active electrolyte (2017)

Active electrolyte enhanced supercapacitors (AEESCs) have received increasing attention because of their large specific capacitance and easy fabrication process. The better matching between the active electrolyte and the counter electrode and the slow self-discharge rate are the challenges of this type of supercapacitor. In this paper, a novel AEESC with polyaniline/reduced graphene oxide hydrogel (PANI/RGOHG) as the anode and Cu(ii) ions as the cathodic active electrolyte is constructed. Experimental results demonstrate that the electrode potentials of PANI and Cu(ii) can match perfectly, thus the device has a wide working voltage range. Because of the large specific capacitance of both PANI and Cu(ii), a high average specific capacitance of a single electrode of 1120 F g<sup>-1</sup> at 2.6 A g<sup>-1</sup> is achieved. Meanwhile, self-discharge is also suppressed because the reduction product of Cu(ii) is immobilized on the electrode. These results demonstrate that the performance of AEESCs strongly depends on the choice of a suitable electrode material, and also reveal that Cu(ii) is a promising cathodic active electrolyte for AEESCs.
How Medical Robots are going to Affect Our Lives (2012)

AbstractAs we look at the fundamental manner in which emerging technologies are altering human life, a natural trend to talk about is how Medical Robots are bringing about the biggest paradigm shift in ways in which human beings are treated and human lives are saved. Medical Robots help surgeons perform surgeries with maximum precision, minimal incision, and minimally deep invasions inside a human body. Such robot-aided minimally invasive surgical procedures with minimal incisions are more successful and are reducing patient pain, need for medications, and duration of hospital stays. Medical robots also include tele-robots that can be controlled by remote, even where the surgeon or his fingers cannot be physically present. Medical robots also include Nano-bots, using microscopic robots that can be swallowed like capsule or injected in blood stream. This article discuss a variety of exciting ways in which medical robots help doctors ranging from general surgery robots, remote-controlled tele-robots to micr...
Successive impulsive noise suppression in OFDM (2010)

We consider orthogonal frequency division multiplexing (OFDM) for high data rate narrowband power line communication (PLC) in the frequency bands up to 500 kHz. In narrowband PLC, the performance is strongly influenced by the impulsive noise with very large amplitudes with short durations. Simple iterative impulsive noise suppression algorithms can effectively improve the error rate performance in OFDM systems. However, the convergence speed depends on the number of subcarriers, N. For N ≤ 256, the algorithms converge slowly or not even at all. In this paper, we extend the iterative receiver design to enable a fast convergence for N ≫ 64 and to improve the error rate performance for N ≤ 64. These extensions include 1) a clipping and nulling technique at the input of the iterative algorithm 2) a novel low complexity syndrome decoder which uses the redundancy that is transmitted for synchronization or other purposes. Simulation results are provided to show the improvement in error rate
Direct water photoelectrolysis with patterned n-GaN (2007)

Direct photoelectrolysis of water was observed using a structured n-GaN photoanode, aqueous NaOH solution, and platinum cathode. The structured n-GaN was formed by selective area regrowth using metal stripes defined by photolithography. Gas evolution from both the n-GaN anode and the platinum cathode was observed under UV irradiation without external bias. The metal stripes eliminated current crowding and the n-GaN regrowth increased specific surface area. As a result, distinct improvements in photocurrent were achieved. The origin of the photocurrent and the conversion efficiency are discussed based on water-splitting reactions and etching reactions.
Kruppel-like Factor 4 Induces <i>p27Kip1</i> Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells (2008)

The zinc finger transcription factor Krüppel-like factor 4 (KLF4) has been implicated in both tumor suppression and progression. However, its function in pancreatic cancer has not been well characterized. Here, we show that pancreatic cancer cell lines expressed various levels of KLF4 RNA and protein. Ectopic expression of KLF4 by FG and BxPC-3 pancreatic cancer cells resulted in cell cycle arrest and marked inhibition of cell growth in vitro and attenuation of tumor growth and metastasis in an orthotopic mouse model. Overexpression of KLF4 also led to significant induction of p27(Kip1) expression, at both the RNA and protein levels, in a dose- and time-dependent manner, indicating that KLF4 transcriptionally regulates the expression of p27(Kip1). Chromatin immunoprecipitation assays consistently showed that KLF4 protein physically interacts with the p27(Kip1) promoter. Promoter deletion and point mutation analyses indicated that a region between nucleotides -435 and -60 of the p27(Kip1) promoter and intact of the three KLF4-binding sites within that region were required for the full induction of p27(Kip1) promoter activity by KLF4. Our findings suggest that KLF4 transactivates p27(Kip1) expression and inhibits the growth and metastasis of human pancreatic cancer.
Automatic Tape-Editing Equipment (1963)

The need for automatically combining fragmentary telemetry tape records into one complete over-all composite record is discussed. The over-all organization of a tape-editing system is broken down into its two main functions: 1) synchronizing the tape transports, 2) measuring the excellence of the tape signals and then carrying out the diversity combination of these signals to form a new edited record. The problems associated with each function are discussed, and conclusions are reached regarding the final form of a tape editor. Finally, a practical tape editor system illustrating these conclusions is described.
Lymphoma Recurrence 5 Years or Later Following Diffuse Large B-Cell Lymphoma: Clinical Characteristics and Outcome (2010)

PURPOSE Patients with diffuse large B-cell lymphoma (DLBCL) usually relapse early following diagnosis but some relapses happen at 5 years or later. Few data exist regarding clinical characteristics and outcome of these patients. PATIENTS AND METHODS We performed a retrospective analysis of all patients from two centers in Lyon, France, between 1985 and 2003 who had a biopsy-proven relapse 5 years or later following diagnosis of DLBCL. All available biopsies were reviewed and immunohistochemistry was completed. Results Among 1,492 patients with DLBCL, 54 were eligible. At diagnosis, 63% of patients had stage I-II, 82% had low/low-intermediate International Prognostic Index (IPI) score, 65% had extranodal involvement, 24% had an indolent component associated with DLBCL, 57% had germinal center phenotype, and 43% had non-germinal center phenotype. Median time from diagnosis to relapse was 7.4 years (range, 5 to 20.5 years). At time of relapse, 83% had DLBCL histology, and 17% had indolent histology. Having an indolent component at diagnosis was associated with indolent histology at relapse (P = .028). Five-year event free-survival (EFS) was 17% for patients with DLBCL relapse and 61% for patients with indolent relapse (P = .027). Five-year overall survival was 27% for patients with DLBCL and 75% for patients with indolent relapse (P = .029). For DLBCL relapse, 3-year EFS was 56% versus 18% with autologous stem-cell transplantation or not, respectively (P = .0661). CONCLUSION Patients with DLBCL who had a late relapse usually had localized stage, favorable IPI score, and extranodal involvement at diagnosis. The outcome of patients with DLBCL at time of relapse remains poor, and aggressive treatment such as autologous stem-cell transplantation should be pursued whenever possible. Biopsy at relapse is essential because some patients relapse with indolent histology.
Periodically patterned germanium surfaces modified to form superhydrophobic, IR-transmissive substrates (2016)

Various periodically patterned, infrared (IR) transmissive germanium substrates were surface modified to alter the surface wettability. Goniometric analysis showed that the surface modification rendered the substrates superhydrophobic. Following the surface modification, it was determined that the desirable IR transmission properties were maintained. Both the hydrophobicity and the IR transmission capabilities of the modified, patterned germanium substrates were shown to be significantly enhanced in comparison to a germanium substrate that underwent the same processes, but was devoid of nanostructures on its surface. The results of this work provide an opportunity for the development of enhanced utility infrared transmissive optics in wet or humid conditions.
Repetitive-scanning derivative spectrometer as a monitor of environmental air pollution (1983)

The derivative spectrometer, developed for monitoring environmental air pollutants, employs signal processing to subtract the mean value of the minima of second derivative from the maximum, and to average the subtracted values. The signal processing leads to compensation of the long-term drift and hence to improvement of the sensitivity, i.e., the detection limit is 2-3 ppb or less for such gases as SO2, NO, and NO2, under circumstances where the ambient temperature fluctuates between 0 and 40 degrees C.