gebhart/patrepeval huggingface dataset:
The pros and cons of split-dose granulocyte colony-stimulating factor alone rather than a single high dose for hematopoietic progenitor cell mobilization in small children (< 15 kg) with solid tumors. (2006)

Hematopoietic progenitor cells were mobilized in 34 children with solid tumors weighing < or = 15 kg using granulocyte colony-stimulating factor alone at the doses of 10, 20 or 2 x 12 microg/kg/day. The mobilization with 2 x 12 microg/kg/day was more efficient than that with 10 mg/kg/day. Although the superiority of the split-dose compared to the single, high daily dose (20 microg/kg/day) was not statistically significant, our results suggest that the 2 x 12 microg/kg/day regimen is interesting.
A novel approach towards automatic data distribution (1995)

Data distribution is one of the key aspects that a parallelizing compiler for a distributed memory architecture should consider, in order to get efficiency from the system. The cost of accessing local and remote data can be one or several orders of magnitude different, and this can dramatically affect performance. In this paper, we present a novel approach to automatically perform static data distribution. All the constraints related to parallelism and data movement are contained in a single data structure, the Communication-Parallelism Graph (CPG). The problem is solved using a linear 0-1 integer programming model and solver. In this paper we present the solution for one-dimensional array distributions, although its extension to multi-dimensional array distributions is also outlined. The solution is static in the sense that the layout of the arrays does not change during the execution of the program. We also show the feasibility of using this approach to solve the problem in terms of compilation time and quality of the solutions generated.
On-line trajectory optimization for kinematically redundant robot-manipulators and avoidance of moving obstacles (2002)

Novel concepts are presented and verified for real-time dynamics trajectory optimization of kinematically redundant manipulators. The considered task of trajectory planning is to follow a moving target in three-dimensional work space. Hereby, the manipulator has to autonomously preserve explicitly formulated kinematic constraints such as moving obstacle avoidance and box-constraints on joint positions as well as dynamic constraints like box-constraints on joint velocities, accelerations and motor torques. The key idea is to transform the resulting overall motion planning problem into a timed series of variational problems, which, in turn, may be formulated as parameter optimization problems, that can be efficiently solved in real-time by the numerical method of sequential quadratic programming. Since the approach does not require an inverse kinematics formulation it is feasible for manipulators with redundant kinematics. The feasibility of the approach has been verified by example of a ten-degrees-of-freedom manipulator model.
RAF Suppression Synergizes with MEK Inhibition in KRAS Mutant Cancer Cells (2014)

KRAS is the most frequently mutated oncogene in human cancer, yet no therapies are available to treat KRAS mutant cancers. We used two independent reverse genetic approaches to identify components of the RAS-signaling pathways required for growth of KRAS mutant tumors. Small interfering RNA (siRNA) screening of 37 KRAS mutant colorectal cancer cell lines showed that RAF1 suppression was synthetic lethal with MEK inhibition. An unbiased kinome short hairpin RNA (shRNA)-based screen confirmed this synthetic lethal interaction in colorectal as well as in lung cancer cells bearing KRAS mutations. Compounds targeting RAF kinases can reverse resistance to the MEK inhibitor selumetinib. MEK inhibition induces RAS activation and BRAF-RAF1 dimerization and sustains MEK-ERK signaling, which is responsible for intrinsic resistance to selumetinib. Prolonged dual blockade of RAF and MEK leads to persistent ERK suppression and efficiently induces apoptosis. Our data underlie the relevance of developing combinatorial regimens of drugs targeting the RAF-MEK pathway in KRAS mutant tumors.
Lysolecithin induces demyelination in vitro in a cerebellar slice culture system (2004)

Demyelination is a hallmark of several human diseases, including multiple sclerosis. To understand better the process of demyelination and remyelination, we explored the use of an in vitro organotypic cerebellar slice culture system. Parasagittal slices of postnatal Day 10 (P10) rat cerebella cultured in vitro demonstrated significant myelination after 1 week in culture. Treatment of the cultures at 7 days in vitro (DIV) with the bioactive lipid lysolecithin (lysophosphatidylcholine) for 15-17 hr in vitro produced marked demyelination. This demyelination was observed by immunostaining for the myelin components myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase). After a transient demyelinating insult with lysolecithin in vitro, the cultures recovered with oligodendrocyte differentiation recapitulating a normal time course; there was initially re-expression of CNPase and MBP during this recovery, and this was followed by MOG. In addition, there seemed to be some limited remyelination during the recovery phase. Lysolecithin thus induces demyelination in an in vitro organotypic cerebellar slice culture system, providing a model system for studying myelination, demyelination, and remyelination in vitro.
A pH cleavable linker for zone diffusion assays and single bead solution screens in combinatorial chemistry (1997)

B. Atrash and M. Bradley, Chem. Commun., 1997, 1397 DOI: 10.1039/A702677C
Green InGaN Light-Emitting Diodes Grown on Silicon (111) by Metalorganic Vapor Phase Epitaxy (2001)

We report on the growth and characterization of green InGaN light-emitting diodes (LEDs) grown on Si (111) substrates using metalorganic vapor phase epitaxy. A single InGaN quantum well active layer has been used. The optical qualities of InGaN on Si(111) and the p–doping efficiency of GaN are discussed. The turn-on voltage of the LED is 6.8 V and the operating voltage is 10.7 V at 20 mA. Electroluminescence of the LEDs starts at a forward bias of 3.5 V. The electroluminescence peaks at 508 nm, with a full-width at half maximum of 52 nm. An optical output power of 6 µW (in ∼ 8π/5 sr) was achieved for an applied current of 20 mA.
New Functionalized Hydroxymethyl Ketones from the Mild and Chemoselective KMnO<sub>4</sub> Oxidation of Chiral Terminal Olefins. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
YIG-tuned Gunn effect oscillator (1967)

A mechanical cavity of coaxial or waveguide type is generally used as a resonator of a Gunn oscillator. Reported here is the use of a resonator consisting of a ferrimagnetic sample instead of the mechanical cavity to obtain the electrically tunable Gun oscillator. The coupling between the Gunn diode and the the ferrimagnetic resonator was experimentally observed and oscillation frequency from 3.2 GHz to 2.4 GHz was obtained proportionally to the applied dc magnetic field.
Computer algebra recipes: a gourmet's guide to mathematical models of science (2001)

adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden.The use of general descriptive names
Soft sensor development and optimization of the commercial petrochemical plant integrating support vector regression and genetic algorithm (2009)

Soft sensors have been widely used in the industrial process control to improve the quality of the product and assure safety in the production. The core of a soft sensor is to construct a soft sensing model. This paper introduces support vector regression (SVR), a new powerful machine learning method based on a statistical learning theory (SLT) into soft sensor modeling and proposes a new soft sensing modeling method based on SVR. This paper presents an artificial intelligence based hybrid soft sensormodeling and optimization strategies, namely support vector regression - genetic algorithm (SVR-GA) for modeling and optimization of mono ethylene glycol (MEG) quality variable in a commercial glycol plant. In the SVR-GA approach, a support vector regression model is constructed for correlating the process data comprising values of operating and performance variables. Next, model inputs describing the process operating variables are optimized using genetic algorithm with a view to maximize the process performance. The SVR-GA is a new strategy for soft sensor modeling and optimization. The major advantage of the strategies is that modeling and optimization can be conducted exclusively from the historic process data wherein the detailed knowledge of process phenomenology (reaction mechanism, kinetics etc.) is not required. Using SVR-GA strategy, a number of sets of optimized operating conditions were found. The optimized solutions, when verified in an actual plant, resulted in a significant improvement in the quality.
INTRODUCTION (2008)

Next to almost every “ethnic hotspot” is another “ethnic spot” that remains conspicuously cool. While Ukrainians and the Baltic republics mobilized in 1991 for independence from the USSR, the Central Asian republics remained bastions of unionism. When Hindu–Muslim riots exploded in the Indian state of Gujarat in 2002, intercommunal peace was the norm in next-door Maharashtra. As Nigeria's Igbo and Hausa-Fulani regions became embroiled in the 1967–70 Biafran civil war, the adjacent Yoruba territory remained relatively calm. And in the international arena, Norway stubbornly kept its distance from the European Union as its neighbor Sweden joined the integrative project in 1995. Even within the hotspots themselves, the heat is not uniform. Some Iraqi villages descend into interconfessional strife while others are more successful at escaping it, and some individuals in Chechnya back independence from Russia while others oppose it. Nor is there consistency over time. The supposedly “age-old enemies” of Yugoslavia, Serbia, and Croatia have been at peace far more often than at war and the same is true with the Hutu and the Tutsi, the groups involved in the tragic Rwandan genocide. Variation such as this constitutes the great puzzle of ethnic politics.
Sparsely Self-Supervised Generative Adversarial Nets for Radio Frequency Estimation (2019)

Radio frequency (RF) estimation plays a significant role in cellular network's planning and optimization. The conventional methods for RF estimation are mainly based on radio propagation models, which suffer from low accuracy and coarse granularity. Distinguished from existing methods, we propose sparsely self-supervised generative adversarial nets (SS-GAN), a novel data-driven model to generate the RF maps of an area from irregularly distributed measurement samples. SS-GAN meticulously adopts the standard GAN framework, where the generator learns the distribution of true observations under the guidance of the discriminator that discriminates whether the input data is from real samples or from generated outputs. Competition in the minmax game between generator and discriminator drives them to improve their capability, until the generator is indistinguishable from the true RF distribution. Specifically, on top of the GAN framework, SS-GAN carries out a variety of operations to enhance the estimation: (1) In addition to observations of the measured RF coverage and RF interference, SS-GAN also employs a collection of crucial auxiliary information (e.g., geographic data) as additional input features to the GAN framework so as to precisely characterize the RF environment; (2) To dampen the training instability, a new lightweight reconstruction loss is introduced to the objective function of SS-GAN rather than solely using the adversarial loss, which aims to impose a weak supervision on the generated RF maps according to estimation accuracy; (3) Moreover, SS-GAN designs an innovative sparsely self-supervised (SS) learning mechanism that facilitates the validation of the estimated results for a model lacking direct ground truth knowledge. Extensive experiments on a real-world 4G LTE dataset demonstrate that SS-GAN can substantially improve the estimation accuracy over the state-of-the-art baselines. Comparison results are presented through visualized case studies and quantitative statistics.
Indolylarylsulfones Bearing Natural and Unnatural Amino Acids. Discovery of Potent Inhibitors of HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase and Coxsackie B4 Virus (2009)

New potent indolylarylsulfone (IAS) HIV-1 NNRTIs were obtained by coupling natural and unnatural amino acids to the 2-carboxamide and introducing different electron-withdrawing substituents at position 4 and 5 of the indole nucleus. The new IASs inhibited the HIV-1 replication in human T-lymphocyte (CEM) cells at low/subnanomolar concentration and were weakly cytostatic. Against the mutant L100I, K103N, and Y181C RT HIV-1 strains in CEM cells, sulfones 3, 4, 19, 27, and 31 were comparable to EFV. The new IASs were inhibitors to Coxsackie B4 virus at low micromolar (2-9 microM) concentrations. Superimposition of PLANTS docked conformations of IASs 19 and 9 revealed different hydrophobic interactions of the 3,5-dimethylphenyl group, for which a staking interaction with Tyr181 aromatic side chain was observed. The binding mode of 19 was not affected by the L100I mutation and was consistent with the interactions reported for the WT strain.
I.—The System Attacked (1926)

Research Article| March 01 1926 I.—The System Attacked Davidy Y. Thomas Davidy Y. Thomas Professor of History and Political Science, University of Arkansas Search for other works by this author on: This Site PubMed Google Scholar Current History (1926) 24 (1): 27–31. https://doi.org/10.1525/curh.1926.24.1.27 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Davidy Y. Thomas; I.—The System Attacked. Current History 1 March 1926; 24 (1): 27–31. doi: https://doi.org/10.1525/curh.1926.24.1.27 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1926 by The Regents of the University of California1926 Article PDF first page preview Close Modal You do not currently have access to this content.
Electron Multiplication and Surface Charge on Zinc Oxide Single Crystals (1968)

Electron multiplication has been observed in ZnO using reverse-biased electrolyte contacts to n-type conducting crystals. Measurements have also been made of the surface potential of the free surface charged by a negative corona discharge in air. The surface charge is discharged by illumination. Under certain conditions electron multiplication contributes to the discharge process. The amount of surface charge discharged by illumination has been measured as a function of the energy of the light. This gives an approximate energy-level spectrum for the localized electrons on the surface.
Beat tracking based on multiple-agent architecture-A real-time beat tracking system for audio signals (1996)

This paper presents an application of multiple-agent architecture to beat tracking for musical acoustic signals. Beat tracking is an important initial step in computer understanding of music and is useful in various multimedia applications. Most previous beat-tracking systems dealt with MIDI signals and were not based on a multiple-agent architecture. Our system can recognize, in real time, temporal positions of beats in real-world audio signals that contain sounds of various instruments. Our application of multiple-agent architecture enables the system to handle ambiguous situations in interpreting real-world input signals and to examine multiple hypotheses of beat positions in parallel. Even if some agents lose track of the beat, other agents will maintain the correct hypothesis. Each agent is able to interact with other agents to track beats cooperatively, and self-evaluate the reliability of its hypothesis on the basis of the current input situation, and adapt to th...
Myelin acquisition in the central nervous system of the mouse revealed by an MBP-Lac Z transgene. (1992)

Myelin has pronounced effects upon the morphology, function, and growth of axons in the mammalian CNS. Consequently, oligodendrocyte development and myelination have been investigated using a wide variety of histological, immunocytochemical, ultrastructural, and biochemical techniques. While many of the spatial and temporal features of myelin appearance have been characterized, for any one species only limited regions of the CNS have been investigated. To address this limitation, we have derived transgenic mice in which the bacterial Lac Z gene is regulated by promoter elements of the myelin basic protein gene. When differentiating oligodendrocytes begin to elaborate recognizable myelin, they initiate expression of the MBP-Lac Z transgene and accumulate readily detectable levels of beta-galactosidase. Here, we exploit the sensitivity, resolution, and ease of beta-galactosidase histochemical assays to characterize the temporal and spatial patterns of CNS myelination in the mouse. Many features of the myelination program revealed by this approach were predicted by the immunocytochemical and ultrastructural data derived from other species. Nonetheless, previously undocumented patterns were also encountered. beta-Galactosidase was expressed first by oligodendrocytes in the ventral spinal cord, 1 d prior to birth. There, myelination proceeded in a strictly rostral-caudal direction, whereas in the dorsal cord, myelination initiated in the cervical enlargement and proceeded in both rostral and caudal directions. In the cerebellum, deep regions myelinated first, and in the optic nerve, myelination initiated at the retinal end. In contrast, the lateral olfactory tracts, pons, and optic chiasm initiated myelination along their entire course.(ABSTRACT TRUNCATED AT 250 WORDS)
Inhibition of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from bovine brain by barbiturates. (1971)

The partially purified NADPH-linked aldehyde reductase (alcohol:NADP oxidoreductase, EC 1.1.1.2) from bovine brain has been further characterized, and inhibition of the enzyme by barbiturates has been investigated. In addition to substituted benzaldehydes and phenylethanols, free indoleacetaldehyde was observed to be a substrate for the enzyme. In the present studies, it was found that brain aldehyde reductase is markedly inhibited by barbital, phenobarbital, pentobarbital, and amobarbital, with K i values ranging from 50 to 400 µM. Inhibition by these agents was reversible and of a noncompetitive type with respect to p -nitrobenzaldehyde, indoleacetaldehyde, p -hydroxyphenylglycolaldehyde, or NADPH. The enzyme was not markedly inhibited by amobarbital alcohol, a normal metabolite of amobarbital, or by barbituric acid; K i values for these compounds were found to be 0.6 and 4 mM, respectively. Evidence is presensted suggesting that inhibition of aldehyde reductase by the barbiturates is due to the ionized form of the inhibitors. Pyrazole, a potent inhibitor of alcohol dehydrogenase, did not inhibit aldehyde reductase, and the barbiturates had no effect on alcohol dehydrogenase. The differential sensitivity of aldehyde reductase to the inhibitory effects of barbiturates and pyrazole is used to distinguish this enzyme from liver alcohol dehydrogenase.
A novel single-stage constant-wattage high-power-factor electronic ballast (1999)

A novel single-stage high-power-factor electronic ballast is presented in this paper. The ballast is obtained from the integration of a buck-boost converter and a half-bridge LC resonant inverter. The ballast features lamp power regulation against line voltage fluctuations together with high power factor and dimming capability. The steady-state analysis of the ballast is performed and a low-frequency model of the input stage is derived. A design example, including closed-loop circuitry, is also presented. Finally, some experimental results from a laboratory prototype are shown.
Effect of Amitriptyline on Symptoms in Treatment Naïve Patients With Interstitial Cystitis/Painful Bladder Syndrome (2010)

When all randomized subjects were considered, amitriptyline plus an education and behavioral modification program did not significantly improve symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome. However, amitriptyline may be beneficial in persons who can achieve a daily dose of 50 mg or greater, although this subgroup comparison was not specified in advance.
Update on infectious enterocolitides and the diseases that they mimic (2014)

The anatomic pathologist's ability to diagnose infections, including gastrointestinal infections, in tissue sections has improved greatly in recent years. With the increasing number and availability of new molecular assays and immunostains, pathologists' understanding of the correlation between histologic patterns of inflammation and specific organisms or groups of organisms has expanded, as well as our understanding of how closely infections can mimic other frequently encountered diseases in gastrointestinal pathology (such as chronic idiopathic inflammatory bowel disease and ischemia). Anatomic pathologists continue to play a critical role in the diagnosis of gastrointestinal infections, as the examination of slides may provide a much more rapid result than microbiological cultures or other laboratory assays, and often cultures are not obtained before the patient is treated with antibiotics. Because many gastrointestinal infections are acquired through contaminated water and food, this review will focus primarily on food and water‐borne infectious enterocolitides.
The Wittig and Related Reactions (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Cryptanalysis of an Image Scrambling Scheme Without Bandwidth Expansion (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Recently, a new image scrambling (i.e., encryption) scheme without bandwidth expansion was proposed based on two-dimensional discrete prolate spheroidal sequences. A comprehensive cryptanalysis is given here on this image scrambling scheme, showing that it is not sufficiently secure against various cryptographical attacks including ciphertext-only attack, known/chosen-plaintext attack, and chosen-ciphertext attack. Detailed cryptanalytic results suggest that the image scrambling scheme can only be used to realize perceptual encryption but not to provide content protection for digital images. </para>
Tietz clinical guide to laboratory tests. (2006)

Section 1 Preanalytical aspects New! Section 2 General Clinical Tests Section 3 Molecular Diagnostics Section 4 Therapeutic Drugs and Drugs of Abuse Section 5 Clinical Microbiology Section 6 Immunophenotyping Markers New! Section 7 Pharmacogenomics New! Section 8 Allergy Testing New! Test Index Disease Index