gebhart/patrepeval huggingface dataset:
IC‐P‐041: EFFICACY AND SAFETY OF MONTHLY SUBCUTANEOUS BAPINEUZUMAB (2014)

This clinical trial aimed to assess the effect of monthly subcutaneous bapineuzumab, a monoclonal anti-amyloid antibody, on cerebral amyloid burden, cognition, and functional ability, and to estimate the incidence of amyloid-related imaging abnormalities-edema/ effusion (ARIA-E) with this treatment regimen. Subjects (50-89 years old, n=146) with mild to moderate AD (MMSE 18-26) and increased amyloid burden on florbetapir PET were randomized to 2, 7 or 20 mg/mo subcutaneous bapineuzumab or placebo in a 1:1:1:1 ratio. Florbetapir PET was to be repeated after 6, 12, and 24 months; MRI (to assess for ARIA-E) every 3 months; and the 11 item ADAS-Cog and DAD at 3, 6, 12, 18, and 24 months. With the negative efficacy results of 2 trials of intravenous bapineuzumab reported in August, 2012, this protocol was amended to reduce the treatment duration to 12 months. Baseline demographics and results are presented in the Table. There was a statistically significant reduction from baseline to month 12 in mean florbetapir PET global cortical average standard uptake value ratio (GCA SUVr) for 7 mg/mo, but no significant differences relative to placebo for any dosage. There were no differences relative to placebo for clinical outcomes at month 12. Only 2 cases of ARIA-E occurred, at 6 months in an ApoE e 4 noncarrier receiving 20 mg/mo (2.7%), and at 9 months in a carrier receiving 2 mg/mo (2.7%). Both cases were asymptomatic, resolved after interruption of bapineuzumab, and did not recur on rechallenge. Monthly SC injections of bapineuzumab 2, 7, and 20 mg for 12 months were generally well tolerated. The incidence proportion of asymptomatic ARIA-E appeared lower for monthly subcutaneous dosages than for equivalent q3m intravenous dosages in prior studies 1. However, the current study did not demonstrate a statistically significant treatment effect on amyloid burden as assessed by florbetapir PET. It is possible that the lack of demonstrable effects on biomarkers and clinical outcomes is related to the truncated treatment duration from 24 to 12 months.1. Salloway et al, N Engl J Med 2014;370:322-33.
U.V. Absorption Band in Ge‐Doped Sodalite Powders (1980)

A bright green luminescence, with an emission bandpeak at 5250Å and an excitation bandpeak at 3465Å, has been reported for germanium‐doped sodalite powders. This article reports the results of an investigation of the properties of u.v. absorption band at 3450Å that is shown to be responsible for the luminescence. A settled slide technique was used to prepare samples so that small variations in the absorption band could be detected. Experimental results are presented that show the effect of the hydrogen annealing temperature, hydrogen annealing time, and F‐center creation on the u.v. absorption band intensity. The results indicate a definite relationship between the u.v. absorption band and the luminescence. The results of the coloration experiments show that the luminescent centers are associated with thermally erasable F‐centers while they are independent of photoerasable F‐centers. The u.v. band was found to exist in sodalite: Cl, Br, and I. While the band intensities differ for those powders, the peak wavelengths are exactly the same. Possible models for both coloration and luminescence are discussed.
Interactive SPH Simulation of Fluid Phenomena (2001)

Interactive simulation technique is incorporated in SPH method which is one of computer simulation methods in modeling and calculating fluid flow by using particles. It is required in the interactive simulation, a simulated object is operated in real-time by equipments of graphical output and controlling device. In the present study, a prototype of simulation program is implemented using “OpenGL” graphics library with perspective for versatile environment of execution. A model of tub charged with liquid (water) and rectangle solid body, which is composed of 301 SPH particles, is investigated in two dimension. It is found that the motion of fluid is induced by the artificial movement of the solid body and a complicated free-surface structure is developed. It is concluded that interactivity facilitate our recognition of phenomena being reproduced in SPH simulation though there remains improvement regarding interactive device and graphical computer resources.
Removal of 238Pu(IV) from Mice by Poly-Catechoylate, -Hydroxamate or -Hydroxypyridinonate Ligands (1989)

Binding of actinide (IV) by plasma proteins impedes excretion. Facilitation of elimination with chelating agents is the only known way to reduce carcinogenic risk. Iron-sequestering agents produced by micro-organisms contain metal-binding groups that bind Pu(IV) at pH 7.4 (catechol, CAM, in enterobactin; hydroxamate, X, in the ferrioxamines; hydroxpyridinone, HOPO). Our synthetic ligands contain up to four such groups linked by alkyl chains or attached to desferrioxamine (DFO) or diethylene-triamine-pentaacetic acid (DPTA). 238Pu excretion was tested in mice given 30 µmol.kg-1 of a ligand. Ligands that removed as much or more Pu than CaNa3-DTPA ((70% of injected Pu (% ID) are, in decreasing order of effectiveness: (1) Fe(III)-3,4,3-LIHOPO, (2) DFO-HOPO, (3) 3,4,3-LIHOPO, (4) 3,4,3-LICAM(C). Orally administered ligands 1-4, (5) 3,4,3-LICAM(S) and (6) ZnNa-DTPA-DX removed as much or more Pu than CaNa3-DTPA (( 15% ID). Ligands 1-4 and 6 injected 24 h after the Pu removed ( 5% ID more than control excretion (equivalent to or better than CaNa3-DTPA). All the new ligands at a dosage of 0.3 µmol.kg-1 removed a significant amount of Pu compared with controls: CaNa3-DTPA was ineffective. Ligand 3 is acutely toxic at high dosage, but the others appear to be of low toxicity. The HOPO ligands and ZnNa-DTPA-DX are recommended for further study.
<title>Measurement of the spatial frequency response (SFR) of digital still-picture cameras using a modified slanted-edge method</title> (2000)

Spatial resolution is one of the main characteristics of electronic imaging devices such as the digital still-picture camera. It describes the capability of a device to resolve the spatial details of an image formed by the incoming optical information. The overall resolving capability is of great interest although there are various factors, contributed by camera components and signal processing algorithms, affecting the spatial resolution. The spatial frequency response (SFR), analogous to the MTF of an optical imaging system, is one of the four measurements for analysis of spatial resolution defined in ISO/FDIS 12233, and it provides a complete profile of the spatial response of digital still-picture cameras. In that document, a test chart is employed to estimate the spatial resolving capability. The calculations of SFR were conducted by using the slanted edge method in which a scene with a black-to- white or white-to-black edge tilted at a specified angle is captured. An algorithm is used to find the line spread function as well as the SFR. We will present a modified algorithm in which no prior information of the angle of the tilted black-to-white edge is needed. The tilted angle was estimated by assuming that a region around the center of the transition between black and white regions is linear. At a tilted angle of 8 degree the minimum estimation error is about 3%. The advantages of the modified slanted edge method are high accuracy, flexible use, and low cost.
Rear view lane detection by wide angle camera (2003)

In this paper a new lane detection method is proposed for a highway lane departure warning system which hardware cost is reduced by using an existing wide-angle back monitor camera and an embedded CPU on the market. The extended Hough transform and a bird's-eye view image are effectively applied to perform realtime lane detection. The method was built on an embedded CPU (Hitachi SH2E) as software. Then the extended Hough transform was executed at less than 66 milliseconds.
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. (1996)

Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to the bacterial MutS protein. In this study the role of MSH2, MSH3, and MSH6 in mismatch repair has been examined by measuring the rate of accumulating mutations and mutation spectrum in strains containing different combinations of msh2, msh3, and msh6 mutations and by studying the physical interaction between the MSH2 protein and the MSH3 and MSH6 proteins. The results indicate that S. cerevisiae has two pathways of MSH2-dependent mismatch repair: one that recognized single-base mispairs and requires MSH2 and MSH6, and a second that recognizes insertion/deletion mispairs and requires a combination of either MSH2 and MSH6 or MSH2 and MSH3. The redundancy of MSH3 and MSH6 explains the greater prevalence of hmsh2 mutations in HNPCC families and suggests how the role of hmsh3 and hmsh6 mutations in cancer susceptibility could be analyzed.
Manipulator Equipped with Counterbalance Mechanism Based on Gear Unit (2014)

일반적으로 산업용 로봇은 가반중량에 비해서 매우 큰 자중을 가지게 되며, 이로 인한 큰 중력토크를 보상하여야 하므로, 고사양의 모터/감속기를 사용하게 되어 제조단가가 높아진다. 이러한 머니퓰레이터의 자중 및 가반중량을 기계식 중력보상장치로 보상하게 된다면, 모터/감속기 사양을 크게 낮추어서 제조단가를 낮출 수 있다. 그러나 기존의 와이어 기반의 중력보상장치의 경우, 내구성 및 파손 등의 문제로 실용성이 낮았다. 본 연구에서는 이를 개선하고자 기어 및 롤러 기반의 내구성 높은 중력보상장치를 개발하고, 이를 사용하여 낮은 용량의 모터/감속기로도 가반하중 목표를 만족시킬 수 있는 중력보상 장치를 탑재한 머니퓰레이터를 개발하였다. 본 연구에서는 다양한 시뮬레이션 및 실험을 통하여 제안한 중력보상장치가 머니퓰레이터의 모든 자세에 대해서 중력에 대한 완전한 보상토크를 제공하였으며, 큰 가반하중에 대해서도 적절한 보상토크를 제공할 수 있음을 보였다.
Understanding Anesthesia Equipment (1977)

Gas Supply and Distribution Systems Medical Gas Cylinders and Containers Medical Gas Pipeline Systems Oxygen Concentrators Anesthesia Machines and Breathing Systems The Anesthesia Machine Vaporizers (Anesthetic Agent Delivery Devices) The Breathing System: General Principles, Common Components and Classifications The Mapleson Breathing Systems The Circle System Manual Resuscitators Humidification Methods Anesthesia Ventilators Controlling Trace Gas Levels Hazards of Anesthesia Machines and Breathing Systems Airway Equipment Face Masks and Airways Laryngeal Mask Airways Laryngoscopes Tracheal Tubes Monitoring Devices Gas Monitoring Airway Pressures, Volumes, and Flows Pulse Oximetry Neuromuscular Transmission Monitoring Temperature Monitoring Alarm Devices Automatic Noninvasive Blood Pressure Monitors Electronic Recordkeeping and Perioperative Information Management Systems Equipment Care and Planning Equipment Checking and Maintenance Cleaning and Sterilization Operating Room Design and Equipment Selection Inde
A Robust Two-Dimensional Hydrogen-Bonded Network:  The Sulfamide Moiety as a New Building Block for the Design of Molecular Solids (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Robust Two-Dimensional Hydrogen-Bonded Network: The Sulfamide Moiety as a New Building Block for the Design of Molecular SolidsBing Gong, Chong Zheng, Ewa Skrzypczak-Jankun, Yinfa Yan, and Jianhua ZhangView Author Information Departments of Chemistry The University of Toledo, Toledo, Ohio 43606 Northern Illinois University, DeKalb, Illinois 60115-2862 Cite this: J. Am. Chem. Soc. 1998, 120, 43, 11194–11195Publication Date (Web):October 20, 1998Publication History Received18 May 1998Published online20 October 1998Published inissue 1 November 1998https://pubs.acs.org/doi/10.1021/ja981707chttps://doi.org/10.1021/ja981707crapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views639Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information SUBJECTS:Amides,Layers,Molecular structure,Molecules,Substituents Get e-Alerts
<i>ARP</i>/<i>wARP</i>'s model-building algorithms. I. The main chain (2002)

Algorithms underlying the automatic model-building functionality of the ARP/wARP software suite are presented. Finding the most likely set of Calpha atoms from a given set of atoms is formulated as a constrained integer programming problem. The objective function is a density-weighted score for the match between observed and expected chain conformation. Graph-search algorithms are presented that find solutions to this problem in an efficient manner.
Copper–cobalt hydroxysalts and oxysalts: bulk and surface characterization (1991)

Copper–cobalt oxysalts of various Cu : Co atomic ratios (100 : 0. 92 : 8, 85 : 15, 77 : 23, 67 : 33, 15 : 85, 0 : 100) have been prepared by coprecipitation, at constant pH, from solutions of copper and cobalt nitrates added to a solution of NaHCO3; the structure and chemical nature of the Cu—Co oxysalts have been investigated by several complementary techniques such as X-ray diffraction (XRD), magnetic susceptibility, reflectance spectroscopy and X-ray photoelectron spectroscopy (XPS) to obtain information both on their bulk and on their surface properties.In the range of Cu : Co atomic ratios from 100 : 0 to 67 : 33 the materials consist of Co-containing malachite, Cu2 –xCoxCO3(OH)2, while for Cu : Co equal to 0 : 100 and 15 : 85 the products are CoCO3, spherocobaltite, and Cu-containing spherocobaltite Co0.85Cu0.15CO3, respectively. From both reflectance spectroscopy and magnetic susceptibility measurements the presence of only Cu2+ and Co2+ species has been ascertained in all materials. Antiferromagnetic interactions are strong at high copper content and become weaker at increasing cobalt loading. The observed decrease in volume of the malachite monoclinic unit cell with incorporation of Co2+ ions, in spite of the larger Co2+ ion radius with respect to that of Cu2+, indicates that distortion of the MO6 polyhedra at the cation site of the malachite lattice is less when Cu2+ is replaced by Co2+. The presence of Cu2+ in the spherocobaltite trigonal lattice shows a small cell volume decrease as expected from ionic radii difference. XPS has confirmed the presence of only Cu2+ and Co2+ species at the surface of the materials. It is also shown that the local nature of the chemical bond is essentially determined by the nature of the first-neighbour ligands. At higher copper content, where the materials are cobalt-containing malachite, the surface is enriched in cobalt.
Towards Big-Data Analysis of Deviation and Error Reports in Product Development Projects (2016)

Large complex system development projects, such as complete truck development projects, take several years to carry out. They involve hundreds of engineers who develop tens of thousands of parts and millions of lines of codes. During a project, many design decisions often need to be changed due to emergence of new information. The bulk of these changes are requested late in the development process. It is known that changes late in the development process are very costly and run a risk of delaying the project. These changes are often well documented in databases, but, due to the complexity of the data, few companies analyze engineering change in a comprehensive and structured fashion. This paper argues that “big data” (specifically data mining) analysis tools can be applied for such analyses and proposes a process for carrying out the analysis and using the results for product and development process improvement. The paper further accounts for experiences gained from testing the approach on a dataset consisting of 4,000 deviation and error reports that were created during a truck development project.
A study of DRAM failures in the field (2012)

Most modern computer systems use dynamic random access memory (DRAM) as a main memory store. Recent publications have confirmed that DRAM errors are a common source of failures in the field. Therefore, further attention to the faults experienced by DRAM sub-systems is warranted. In this paper, we present a study of 11 months of DRAM errors in a large high-performance computing cluster. Our goal is to understand the failure modes, rates, and fault types experienced by DRAM in production settings. We identify several unique DRAM failure modes, including single-bit, multi-bit, and multi-chip failures. We also provide a deterministic bound on the rate of transient faults in the DRAM array, by exploiting the presence of a hardware scrubber on our nodes. We draw several conclusions from our study. First, DRAM failures are dominated by permanent, rather than transient, faults, although not to the extent found by previous publications. Second, DRAMs are susceptible to large multi-bit failures, such as failures that affect an entire DRAM row or column, indicating faults in shared internal circuitry. Third, we identify a DRAM failure mode that disrupts access to other DRAM devices that share the same board-level circuitry. Finally, we find that chipkill error-correcting codes (ECC) are extremely effective, reducing the node failure rate from uncorrected DRAM errors by 42x compared to single-error correct/double-error detect (SEC-DED) ECC.
The use of automated electrospray ionization tandem MS for the diagnosis of inborn errors of metabolism from dried blood spots (1996)

Conference Article| August 01 1996 The use of automated electrospray ionization tandem MS for the diagnosis of inborn errors of metabolism from dried blood spots A. W. Johnson; A. W. Johnson 1Biochemistry Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar K. Mills; K. Mills 1Biochemistry Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar P. T. Clayton P. T. Clayton 1Biochemistry Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (3): 932–938. https://doi.org/10.1042/bst0240932 Article history Received: March 20 1996 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation A. W. Johnson, K. Mills, P. T. Clayton; The use of automated electrospray ionization tandem MS for the diagnosis of inborn errors of metabolism from dried blood spots. Biochem Soc Trans 1 August 1996; 24 (3): 932–938. doi: https://doi.org/10.1042/bst0240932 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: LSI, liquid secondary ionization, ESI, electrospray ionization This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Bone Cell Expression on Titanium Surfaces is Altered by Sterilization Treatments (1994)

Phenotypic responses of rat calvarial osteoblast-like cells (RCOB) were evaluated on commercially pure titanium (cpTi) surfaces when cultured at high density (5100 cells/mm2). These surfaces were prepared to three different clinically relevant surface preparations (1-micron, 600-grit, and 50-microns-grit sand-blast), followed by sterilization with either ultraviolet light, ethylene oxide, argon plasma-cleaning, or routine clinical autoclaving. Osteocalcin and alkaline phosphatase, but not collagen expression, were significantly affected by surface roughness when these surfaces were altered by argon plasma-cleaning. In general, plasma-cleaned cpTi surfaces demonstrated an inverse relationship between surface roughness and phenotypic markers for a bone-like response. On a per-cell basis, levels of the bone-specific protein, osteocalcin, and the enzymatic activity of alkaline phosphatase were highest on the smooth 1-micron polished surface and lowest on the roughest surfaces for the plasma-cleaned cpTi. Detectable bone cell expression can be altered by clinically relevant surfaces prepared by standard dental implant preparation techniques.
The First 5 Amino Acids of the Carboxyl Terminus of Phosphatidylinositol Transfer Protein (PITP) α Play a Critical Role in Inositol Lipid Signaling (1997)

Phosphatidylinositol transfer protein (PITP) is essential for phospholipase C signaling and for constitutive and regulated vesicular traffic. PITP has a single lipid-binding site that can reversibly bind phosphatidylinositol (PI) and phosphatidylcholine (PC) and transfer these lipids between membrane compartments in vitro. The role of the carboxyl terminus was examined by comparing wild-type PITPalpha with PITPalpha in which 5, 10, and 20 amino acids were deleted from the C terminus. Delta5- and Delta10-PITP had reduced PI and PC transfer activities compared with wild-type PITP, with the effect on PI transfer being more marked than that on PC transfer. Delta20-PITP was inactive at all concentrations tested. All three truncated mutants were unable to restore G-protein-mediated phospholipase Cbeta stimulation in HL-60 cells. Delta5- and Delta10-PITP, but not Delta20-PITP, inhibited the signaling function of wild-type protein without any effect on lipid transfer in vitro. We conclude that (a) the carboxyl terminus of PITP plays a critical role in phospholipase C signaling; (b) the transfer activity is not the only determining factor that dictates the restorative function of PITP in inositol lipid signaling; and (c) the dominant inhibitory effects of Delta5- and Delta10-PITP on wild-type PITP in phospholipase C signaling suggest the existence of a receptor for PITP.
Determination of stable carbon isotopes of organic acids and carbonaceous aerosols in the atmosphere (2006)

A wet oxidation method for the compound-specific determination of stable carbon isotopes (delta(13)C) of organic acids in the gas and aerosol phase, as well as of water-soluble organic carbon (WSOC), is presented. Sampling of the organic acids was done using a wet effluent diffusion denuder/aerosol collector (WEDD/AC) coupled to an ion chromatography (IC) system. The method allows for compound-specific stable carbon isotope analysis by collecting different fractions of organic acids at the end of the IC system using a fraction collector. delta(13)C analyses of organic acids were conducted by oxidizing the organic acids with sodium persulfate at a temperature of 100 degrees C and determining the delta(13)C value of the resulting carbon dioxide (CO(2)) with an isotope ratio mass spectrometer. In addition, analysis of delta(13)C of the WSOC was performed for particulate carbon collected on aerosol filters. The WSOC was extracted from the filters using ultrapure water (MQ water), and the dissolved organic carbon was oxidized to CO(2) using the oxidation method. The wet oxidation method has an accuracy of 0.5 per thousand with a precision of +/-0.4 per thousand and provides a quantitative result for organic carbon with a detection limit of 150 ng of carbon.