gebhart/patrepeval huggingface dataset:
Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: &#x201C;Reverse Pharmacology&#x201D; and &#x201C;Bedside to Bench&#x201D; Approach (2011)

Inflammation, although first characterized by Cornelius Celsus, a physician in first Century Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a link between inflammation and cancer, cardiovascular diseases, diabetes, pulmonary diseases, neurological diseases and other chronic diseases. Extensive research within last three decades has confirmed these observations and identified the molecular basis for most chronic diseases and for the associated inflammation. The transcription factor, Nuclear Factor-kappaB (NF-kappaB) that controls over 500 different gene products, has emerged as major mediator of inflammation. Thus agents that can inhibit NF-kappaB and diminish chronic inflammation have potential to prevent or delay the onset of the chronic diseases and further even treat them. In an attempt to identify novel anti-inflammatory agents which are safe and effective, in contrast to high throughput screen, we have turned to "reverse pharmacology" or "bed to benchside" approach. We found that Ayurveda, a science of long life, almost 6,000 years old, can serve as a "goldmine" for novel anti-inflammatory agents used for centuries to treat chronic diseases. The current review is an attempt to provide description of various Ayurvedic plants currently used for treatment, their active chemical components, and the inflammatory pathways that they inhibit.
Microwave Radar-Based Differential Breast Cancer Imaging: Imaging in Homogeneous Breast Phantoms and Low Contrast Scenarios (2010)

This paper presents an improved antenna array for radar-based breast cancer imaging. The improvement was achieved by increasing the number of antennas in the array to 31 elements, as well as by improving the antenna design itself. Using an experimental setup, with homogeneous curved breast phantoms, we have demonstrated substantial imaging improvement with the new antenna array. The new system is also able to detect 7 mm-diameter tumor phantoms in any location within the breast, even as close as 4 mm from the skin layer. Additionally, we have shown good imaging results in low-contrast scenarios, where the dielectric contrast between tumor and normal tissue was reduced to 2:1. Presented results clearly demonstrate the large impact of antenna's characteristics on imaging performance.
Antimicrobial activity of the volatile constituents of Perilla frutescens and its synergistic effects with polygodial (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleAntimicrobial activity of the volatile constituents of Perilla frutescens and its synergistic effects with polygodialRaphael. Kang, Randi. Helms, Michael J. Stout, Hasan. Jaber, Zhengqing. Chen, and Tetsuo. NakatsuCite this: J. Agric. Food Chem. 1992, 40, 11, 2328–2330Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://doi.org/10.1021/jf00023a054Request reuse permissionsArticle Views543Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (432 KB) Get e-Alertsclose Get e-Alerts
Location Discovery Using Data-Driven Statistical Error Modeling (2006)

We have developed statistical error modeling techniques for acoustic signal detection-based ranging measurements in the framework of wireless ad-hoc sensor networks (WASNs). The models are used as the basis for solving the location discovery problem in sensor networks. We first demonstrate that the major difficulty in location discovery is how to treat errors by proving the location discovery in presence of noisy measurements is a NP-complete problem, even in onedimensional space. Consequently, we formulate the location discovery as an instance of nonlinear function minimization that optimizes each of the empirically derived statistical error models. The minimization problem is then solved using a conjugate gradient-based nonlinear function optimization solver. We validate the efficiency of the approach by conducting comprehensive experiments on both deployed and simulated WASNs. The results indicate that the statistical model-based approach significantly improves the location accuracy compared with the approaches using the traditional optimization objectives. In addition, the localized version of our location discovery algorithm is capable of finding competitive solutions using significantly lower communication cost.
Performance of Sandwich Structures with Composite Reinforced Core (2000)

Sandwich panels with a foam core reinforced with composite laminates were investigated. The effective material properties of the reinforced core were obtained by homogenization. The general equations of equilibrium for sandwich plates were derived and used for parametric studies of the behavior of the sandwich plates. Three Point Bending tests were performed to experimentally measure the bending stiffness along with the strength of sandwich beams. The test results were also used to verify the analytical solution obtained by using the sandwich plate theory. It was found that local indentation must be included in the theoretical model. Static punching tests (SPT) and low velocity impact (LVI) tests were performed to investigate the behavior of sandwich plates under static and dynamic point loads. The force-displacement relations were modeled based on indentation data. The damage modes, effects of the core reinforcement, and effects of the foam were investigated. A second manufacturing method for constructing the reinforced core was presented, and its properties were compared with those obtained using the original manufacturing method.
Mobilization of long-term reconstituting hematopoietic stem cells in mice by recombinant human interleukin 7. (1995)

Administration of recombinant human interleukin 7 (rh)IL-7 to mice has been reported by our group to increase the exportation of myeloid progenitors (colony-forming unit [CFU]-c and CFU-granulocyte erythroid megakarocyte macrophage) from the bone marrow to peripheral organs (blood, spleen[s], and liver). We now report that IL-7 also stimulates a sixfold increase in the number of more primitive CFU-S day 8 (CFU-S8) and day 12 (CFU-S12) in the peripheral blood leukocytes (PBL) of mice treated with rhIL-7 for 7 d. Moreover, > 90% of lethally irradiated recipient mice that received PBL from rhIL-7-treated donor mice have survived for > 6 mo whereas none of the recipient mice that received an equal number of PBL from diluent-treated donors survived. Flow cytometry analysis at 3 and 6 mo after transplantation revealed complete trilineage (T, B, and myelomonocytic cell) repopulation of bone marrow, thymus, and spleen by blood-borne stem/progenitor cells obtained from rhIL-7-treated donor mice. Thus, IL-7 may prove valuable for mobilizing pluripotent stem cells with long-term repopulating activity from the bone marrow to the peripheral blood for the purpose of gene modification and/or autologous or allogeneic stem cell transplantation.
Linear Inversion of Band-Limited Reflection Seismograms (1986)

We present a method for the linear inversion (deconvolution) of band-limited reflection seismograms. A large convolution problem is first broken up into a sequence of smaller problems. Each small problem is then posed as an optimization problem to resolve the ambiguity presented by the band-limited nature of the data. A new cost functional is proposed that allows robust profile reconstruction in the presence of noise. An algorithm for minimizing the cost functional is described. We present numerical experiments which simulate data interpretation using this procedure.
Effect of adrenergic agents and their mode of action on mucociliary clearance in man (1976)

The aerosolized adrenergic (ADR) agent, isoproterenol (ISO), was found markedly to accelerate mucus clearance within the human tracheobronchial tree. Mucus transport was measured by external gamma counting of aerosolized Fe2O3 particles deposited on the mucous membrane during inhalation. Aerosolized epinephrine (EPI), despite its alpha-ADR bronchial vasoconstrictor activity, increased mucus clearance to the same degree as did aerosolized ISO, with its beta-ADR bronchial vasodilator activity. The vehicle used for delivery of the ADR agents, i.e., a H2O aerosol by intermittent positive-pressure breathing (IPPB), itself increased mucus clearance slightly, but did not elicit the enormous increases produced by the ADR agents. Parenteral ISO caused increases in clearances similar to aerosolized ISO and EPI (consistent with different tissue drug levels achieved). Oral atropine delayed clearance, but atropine prior to an ADR aerosol did not alter the mucus transport effect of the ADR agent. ISO and atropine, despite opposite effects on mucus clearance, caused equal bronchodilation. Thus, increased clearance following aerosolized ISO was not dependent on bronchial vasodilation, aqueous aerosol droplets, reflex parasympathetic activation, or bronchodilation, and seems best attributable to increased ciliary beat rate.
Improved granular activated carbon for the stabilization of wastewater PH (1996)

Two novel analogues, N-[2-amino-4-ethyl[(pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid (2) and N-[2-amino-4-ethyl-6-methyl[(pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid (4), were designed and synthesized as potent dual inhibitors of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) and as antitumor agents. Compound 2 had inhibitory potency against human DHFR similar to N-[4-[2-(amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid (LY231514) and 1, whereas 4 was inactive against human DHFR. Both 2 and 4 were more potent than LY231514 against E. coliTS. Against human TS, 2 was 7-fold less potent than LY231514 and 4 showed similar inhibitory activity as LY231514. In contrast to 2, which was an efficient substrate of human folypolyglutamate synthetase (FPGS), 4 was a poor substrate of FPGS. Compound 2 showed GI50 values in the nanomolar range against more than 18 human tumor cell lines in the standard NCI preclinical in vitro screen.
Using Flow Cytometry to Compare the Dynamics of Photoreceptor Outer Segment Phagocytosis in iPS-Derived RPE Cells (2012)

Caution should be exercised to not use RPE grafts until demonstrating that they are fully functional. The density of the phagocytosis receptors is dynamic and may be used as a predictor for how well the iPS-RPE cells will function in vivo. The phagocytosis dynamics observed between iPS-RPE and primary RPE is very encouraging and adds to mounting evidence that iPS-RPE may be a viable replacement for dysfunctional or dying RPE in human patients.
Level estimation in oil/water separators based on multiple pressure sensors and multivariate calibration (2010)

Abstract Separation of oil, water and gas is an important process stage in oil and gas production. Such mixed fluids with different densities are often separated using a gravity separator. An unwanted emulsion will develop in the layer between oil and water and should not be a part of the oil output flow from the separator. The level and thickness of the emulsion layer together with oil and water content is therefore one of the important properties when controlling the oil output flow rate. The water output flow can be used to adjust the position of the interface/emulsion layer which should be below the oil output. Most of the level estimators are based on radioactive level measurements where the radiation is influenced by the density of the liquids. The radioactive principle is however expensive, and the resolution depends on the number of receivers and the robustness of the software. The main disadvantage is that process operators are exposed to radiation. This paper shows how a set of inexpensive pressure sensors and radar is used together with multivariate calibration for the estimation of the levels and the positions of the different layers in a vertical oil/water/gas separator. The method is calibrated and tested on a pilot scale vertical separator based on the same design as full‐scale separators used in the oil/gas industry. The signals from the radar and pressure sensors are calibrated against known reference levels using partial least squares regression (PLSR). Models based on both competitive and complementary sensor inputs are evaluated. Copyright © 2010 John Wiley & Sons, Ltd.
Estrogen and the Growth of Breast Cancer: New Evidence Suggests Indirect Action (1980)

The growth of the MCF-7 human breast cancer cell line is unresponsive to the presence of estrogen in culture media. Paradoxically, in nude mice, growth of these cells and formation of solid tumors are dependent on estrogen. Tumors fail to develop in ovariectomized mice, but do develop in intact mice and in ovariectomized mice given estrogen. Primary cultures derived from MCF-7 tumors revert to unresponsiveness to estrogen. However, when these cultures are again transplanted into nude mice, estrogen is required for tumor formation. The continuous culture, the solid tumor, and the primary cultures therefrom have similar estrogen-binding capacities and affinities. These results indicate that mammary carcinoma cell growth in vivo is subject to inhibition that can be overcome by estrogen.
Trimedlure: Effects of Structural Modifications on Its Attractiveness to Mediterranean Fruit Fly Males (Diptera: Tephritidae) (1994)

Journal Article Trimedlure: Effects of Structural Modifications on Its Attractiveness to Mediterranean Fruit Fly Males (Diptera: Tephritidae) Get access A. B. Demilo, A. B. Demilo Search for other works by this author on: Oxford Academic PubMed Google Scholar R. T. Cunningham, R. T. Cunningham Search for other works by this author on: Oxford Academic PubMed Google Scholar T. P. McGovern T. P. McGovern Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 87, Issue 6, 1 December 1994, Pages 1494–1501, https://doi.org/10.1093/jee/87.6.1494 Published: 01 December 1994 Article history Received: 18 November 1993 Accepted: 01 July 1994 Published: 01 December 1994
Cell-Derived Extracellular Matrix: Basic Characteristics and Current Applications in Orthopedic Tissue Engineering (2015)

The extracellular matrix (ECM) is a dynamic and intricate microenvironment with excellent biophysical, biomechanical, and biochemical properties, which can directly or indirectly regulate cell proliferation, adhesion, migration, and differentiation, as well as plays key roles in homeostasis and regeneration of tissues and organs. The ECM has attracted a great deal of attention with the rapid development of tissue engineering in the field of regenerative medicine. Tissue-derived ECM scaffolds (also referred to as decellularized tissues and whole organs) are considered a promising therapy for the repair of musculoskeletal defects, including those that are widely used in orthopedics, although there are a few shortcomings. Similar to tissue-derived ECM scaffolds, cell-derived ECM scaffolds also have highly advantageous biophysical and biochemical properties, in particular their ability to be produced in vitro from a number of different cell types. Furthermore, cell-derived ECM scaffolds more closely resemble native ECM microenvironments. The products of cell-derived ECM have a wide range of biomedical applications; these include reagents for cell culture substrates and biomaterials for scaffolds, hybrid scaffolds, and living cell sheet coculture systems. Although cell-derived ECM has only just begun to be investigated, it has great potential as a novel approach for cell-based tissue repair in orthopedic tissue engineering. This review summarizes and analyzes the various types of cell-derived ECM products applied in cartilage, bone, and nerve tissue engineering in vitro or in vivo and discusses future directions for investigation of cell-derived ECM.
Construction of Cyclopentanol Derivatives via Three-Component Coupling of Silyl Glyoxylates, Acetylides, and Nitroalkenes (2012)

The three-component coupling of Mg acetylides, silyl glyoxylates, and nitroalkenes results in a highly diastereoselective Kuwajima-Reich/vinylogous Michael cascade that provides tetrasubstituted silyloxyallene products. The regio- and diastereoselectivity were studied using DFT calculations. These silyloxyallenes were converted to cyclopentenols and cyclopentitols via a unique Lewis acid assisted Henry cyclization. The alkene functionality present in the cyclopentanol products can be elaborated using diastereoselective ketohydroxylation reactions.
Urine pH and the relationship between urine flow and urinary prostaglandin E excretion in the rat (1986)

The relationship between urine flow and urinary prostaglandin E (PGE) excretion was investigated at constant urine pH in the anaesthetized rat. The urine pH was maintained at approximately pH 6 or pH 8 by the intravenous infusion of either ammonium chloride or sodium bicarbonate respectively. Two distinct patterns in the relationship between PGE excretion and urine flow were observed. The first showed a fall in urinary PGE excretion as the urine flow increased over the low flow range of 2-5 ml/h, and was common to both experiments. The second relationship, however, showed a marked difference between the ammonium chloride and sodium bicarbonate experiments since: (a) in acidic urine (pH 6), PGE excretion increased (P less than 0.002) with the urine flow, attaining a rate of 87 +/- 6 pmol/h (n = 6) at the highest level of flow achieved (12 ml/h); (b) in alkaline urine (pH 8), PGE excretion was significantly (P less than 0.01) higher but did not increase with urine flow, remaining constant at approximately 90 pmol/h (n = 6). The lack of any additive effect on urinary PGE excretion between increasing the urine flow and making the urine alkaline may be explained by both stimuli acting through a common mechanism, a concept which is consistent with the hypothesis that PGE may be reabsorbed in the distal nephron. The flow-dependency of urinary PGE excretion could therefore result from a reduction in reabsorption rather than the increase in passive secretion proposed previously.(ABSTRACT TRUNCATED AT 250 WORDS)
Real-time PD identification in diagnosis of GIS using symmetric and asymmetric UHF sensors (2003)

A new practical method for real-time insulation diagnosis of GIS is introduced: a conical coupler is used as an asymmetric UHF sensor while a loop electrode embedded in barrier insulator as a symmetric one. This method can immediately identify the kinds of defects in GIS and discriminate inside partial discharge (PD) from noises by taking single PD pulse. This is because the output ratio of those UHF sensors shows the instinct difference in the kinds of defects due to dissimilar electromagnetic field distributions in GIS. The method will lead to sequential risk assessment based on each identified PD pulse.
An optoelectric plantar "shear" sensing transducer: design, validation, and preliminary subject tests (1996)

A prototype miniature plantar shear sensing transducer was developed, characterized, and tested in this study. Electro-optical components were chosen for the design because of the fast response time, low cost, small size, low power requirements, and adaptability to this application. The optoelectric circuit employed a 660 nm wavelength light source and photodiode solar cell. Signal amplification and sensitivity were adjusted to provide an output voltage proportional to light power. The sensor shell was designed to encapsulate the electro-optical sensing components while providing mechanical resistance to shear through a spring mechanism. A naval bronze was chosen for the shell due to its strength and nonreflective characteristics (alloy of copper and tin). Static and dynamic characteristics of the shear sensor were determined through a series of calibration tests. Mechanical crosstalk sensitivity ranged from 14.34 to 30.51 mV/N. This represented 1% full-scale/Newton sensitivity. Nonlinearity averaged 5.6% in the forward direction and 7.6% in the reverse direction. Overall sensor output hysteresis was 1.1 +/- 3.1% while the natural frequency of the sensor to an input shear transient was approximately 5 Hz. Temperature sensitivity was -7.0 mV/degree C or 3.5% full-scale/degree C. Testing of five adult subjects revealed peak anterior-posterior shear ranging from 6.7 kPa (posterior heel) to 51.4 kPa (great toe) and medial-lateral shear ranging from 5.4 kPa (great toe) to 43.5 kPa (first metatarsal head). Stress-time integral values ranged from 0.78 kPa-sec (posterior shear at the posterior heel) to 37.3 kPa-sec (medial shear at the posterior heel). Contact durations ranged from 0.28 sec (posterior shear at the posterior heel) to 1.25 sec (medial shear at the posterior heel). Further application of the sensor for plantar shear characterization in able-bodied subjects and those with pathology is suggested.