gebhart/patrepeval huggingface dataset:
The pressures of some solid-solid transitions (1962)

A free piston gage capable of measuring pressures to 60 kb has been constructed. The basic element of the gage is a supported carbide vessel entered by a rotating piston. With this apparatus the pressures of various transitions have been determined with fair precision. We find the following pressures: Teflon, 5.43 kb; AgNO3 I-AgNO3 II, 9.78 kb; KI I-KI II, 17.48 kb; KBr I-KBr II, 17.88 kb; KCl I-KC1 II, 19.28 kb; KCN I-KCN II, 19.72 kb; Ice VI-Ice VII, 21.42 kb; AgNO3 II-AgNO3 III, 21.2 kb; Cs I-Cs II, 22.6 kb; Bi I-Bi II, 25.38 kb; Bi II-Bi III, 26.92 kb; Tl II-Tl III, 36.69 kb; Te I-Te II, 40.12 kb; Cs II-Cs III, 41.7 kb; Ba II-Ba III, 59.6 kb. These results are in close agreement with earlier measurements of discontinuities in volume made by Bridgman.
AlGaInN Violet Laser Diodes Grown on GaN Substrates with Low Aspect Ratio (2004)

AlGaInN violet laser diodes grown on GaN substrates have been studied. Waveguide simulations have been performed and perpendicular radiation angles have been investigated. A peculiar layer structure has been proposed to reduce the perpendicular radiation angle and compared with a conventional laser. The laser structure has an n-cladding layer consisting of three AlGaN films, the middle film of which has relatively high Al composition. A laser diode with an optimized structure has been fabricated. The threshold current density and slope efficiency have been 2.9 kA/cm2 and 1.4 W/A, respectively. The perpendicular radiation angle has been as small as 16.2°. The AlGaInN violet laser diode with a low aspect ratio of 1.6 and a small threshold current of 29 mA has been realized.
Detection of packed executables using support vector machines (2011)

Executable packer is a kind of software protecting tools originally designed to pack the information of important programs against malicious reverse engineering. However, packing has also become one of the code obfuscation means prevailing among malware society. Using compression and encryption tactics, packers are able to alter the appearance of malware to confuse detection mechanisms such as pattern matching and heuristics analysis. Therefore, a generic packing detection framework (PDF) is proposed in this study. This framework first statically examines the Portable Executable (PE) file of each executable to gather a set of executable-related raw attributes. After running a subsequent attribute refinement process provided by PDF, valued attributes are extracted and then used to train a two-class support vector machines learning classifier to recognize whether a executable is packed. By evaluating on 1,056 non-packed and 3,784 packed executables, the resulting performances demonstrated that our PDF is promising in packing detection.
Acid sensing ion channels - novel therapeutic targets for ischemic brain injury (2006)

Ischemic stroke is a leading cause of death and long-term disability in the United States. Unfortunately there is no effective therapeutic intervention other than the use of thrombolytics, which has a limited therapeutic time window of approximately 3 h and the potential side effect of intracranial hemorrhage. The absence of neuroprotective therapy is particularly apparent following the failure of multiple clinical trials using glutamate antagonists as therapeutic agents. Understanding the detailed biochemical changes associated with brain ischemia and the cellular mechanisms involved in ischemic brain injury are critical for establishing new and effective neuroprotective strategy. Dramatically decreased tissue pH, or acidosis, is a common feature of ischemic brain, and has been suggested to play a role in neuronal injury. However, the detailed cellular and molecular mechanisms of such acid induced injury remain elusive. The recent finding that acidosis activates a distinct family of cation channels, the acid-sensing ion channels (ASICs), in both peripheral and central neurons has dramatically changed the landscape of brain ischemia neurochemistry and provided a novel therapeutic target. In CNS neurons, lowering extracellular pH to the level commonly seen in ischemic brain activates inward ASIC currents resulting in membrane depolarization. In the majority of these neurons, ASICs are also permeable to Ca2+. Therefore, activation of these channels induces an increase of [Ca2+]i. Incubation of neurons with acidic solutions reproduces Ca2+-dependent neuronal injury independent of glutamate receptor activation. The acid-induced currents, membrane depolarization, [Ca2+]i increase, and neuronal injury can be inhibited by the blockade of ASIC1a. In focal ischemia, ASIC1a blockade, or ASIC1a gene knockout both protect brain from injury. The blockers of ASIC1a also demonstrate a prolonged therapeutic time window, beyond that of the glutamate antagonists. Thus, Ca2+-permeable ASIC1a may represent a novel therapeutic target for ischemic brain injury.
ChemInform Abstract: Aldehydes via Palladium Catalyzed Reductive Carbonylation of Esters. (1987)

Abstract Acetaldehyde (IV) is prepared from methyl acetate (I) by reaction with synthesis gas (II) and (III) in the presence of a palladium catalyst.
Effect of repaglinide addition to metformin monotherapy on glycemic control in patients with type 2 diabetes. (1999)

Combined metformin and repaglinide therapy resulted in superior glycemic control compared with repaglinide or metformin monotherapy in patients with type 2 diabetes whose glycemia had not been well controlled on metformin alone. Repaglinide monotherapy was as effective as metformin monotherapy.
Rigid‐rod liquid crystalline polyesters based on n‐alkoxyterephthalic acid and 4,4′‐dihydroxybiphenyl (1998)

The synthesis and the characterization of a set of polymers obtained by polycondensation of n-alkoxyterephthalic acid (n = 1, 3, 5, 7) and 4,4′-dihydroxybiphenyl are reported. The n-alkoxy insertion promotes the processability of the material by lowering the melting temperature. All polymers show the nematic phase at about 300°C, almost independently of the length of lateral substituent. The isotropization is not observed up to 450°C, where thermal decomposition occurs. The temperature of glass transition decreases with increasing n, ranging from 170°C (n = 5) to 220°C (n = 1). © 1998 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 36: 263–267, 1998
Sample Preparation for Chromatography of Amino Acids: Acid Hydrolysis ofProteins (1985)

Abstract A number of variations were evaluated in the techniques and procedures of the classical 6N hydrochloric acid, 110°C, 24 h hydrolysis of protein. Variations included the use of glass tubes with Teflon-lined screw caps as the hydrolysis vessel, high-temperature short-time hydrolysis, performic acid oxidation of cystine and methionine, multiple hydrolysis times at 145°C, and interlaboratory preparation of hydrolysates. A diverse sample set used in the study included a range of protein-containing matrices, and automated ionexchange chromatography was used for the amino acid analysis. Results show that for hydrolysis in glass tubes with Teflon-lined screw caps at 110°C for 24 h, recoveries of amino acids were in good agreement with recoveries by classical hydrolysis in sealed glass ampoules at reduced pressure. Recoveries from a higher temperature hydrolysis, i.e., 145°C for 4 h and using sealed ampoules, were also in agreement with 110°C, 24 h, sealed ampoule results; the former procedure yielded increased isoleucine and valine and decreased serine and threonine values. Glass tubes with Teflon-lined screw caps for hydrolysis were found to be a practical and convenient alternative to sealed glass ampoules; the improved precision with the former was probably due to the simplicity of the method. The average recovery of cystine from a wide range of matrices without the use of performic acid was 55.5% compared with results obtained with performic acid oxidation. Similarly, methionine is preferably analyzed as methionine sulfone. Interlaboratory evaluation of 145°C, 4 h hydrolysis, in which one laboratory used sealed ampoules and the other laboratory used Teflon-lined screw-cap tubes, demonstrated excellent agreement of amino acid values.
Study of a SiC Trench MOSFET Edge-Termination Structure with a Bottom Protection Well for a High Breakdown Voltage (2020)

A novel edge-termination structure for a SiC trench metal–oxide semiconductor field-effect transistor (MOSFET) power device is proposed. The key feature of the proposed structure is a periodically formed SiC trench with a bottom protection well (BPW) implantation region. The trench can be filled with oxide or gate materials. Indeed, it has almost the same cross-sectional structure as the active region of a SiC trench MOSFET. Therefore, there is little or no additional process loads. A conventional floating field ring (FFR) structure utilizes the spreading of the electric field in the periodically depleted surface region formed between a heavily doped equipotential region. On the other hand, in the trenched ring structure, an additional quasi-equipotential region is provided by the BPW region, which enables deeper and wider field-spreading profiles, and less field crowding at the edge region. The two-dimensional Technology Computer Aided Design (2D-TCAD) simulation results show that the proposed trenched ring-edge termination structures have an improved breakdown voltage compared to the conventional floating field ring structure.
Collision Risk Rating of Traffic Scene from Dashboard Cameras (2017)

We propose a novel middle level estimation of traffic scenes: Collision Risk Rating (CRR). Given a video sequence from a dashboard camera as input, the objective is to estimate a rate that describes "how likely a collision could happen". CRR's problem setting is similar to that of video classification, but it is more complicated and requires rich feature representations to capture the different aspects of the global scene, as well as additional mechanisms to take care of the internal relationships between rating labels. We propose an approach for CRR that features with: (1) a video representation that computed by learned Two-Stream CNNs; and (2) a rank learning based approach for predicting rating labels. The approach was evaluated on a novel prepared Traffic Collision Dataset, and was confirmed to be superior to state-of- the-art video classification approaches.
Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-<i>N</i>-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor (2009)

GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide) is a potent, selective Hedgehog (Hh) signalling pathway inhibitor being developed for the treatment of various cancers. The in vivo clearance of GDC-0449 was estimated to be 23.0, 4.65, 0.338, and 19.3 ml min(-1) kg(-1) in mouse, rat, dog and monkeys, respectively. The volume of distribution ranged from 0.490 in rats to 1.68 l kg(-1) in mice. Oral bioavailability ranged from 13% in monkeys to 53% in dogs. Predicted human clearance using allometry was 0.096-0.649 ml min(-1) kg(-1) and the predicted volume of distribution was 0.766 l kg(-1). Protein binding was extensive with an unbound fraction less than or equal to 6%, and the blood-to-plasma partition ratio ranged from 0.6 to 0.8 in all species tested. GDC-0449 was metabolically stable in mouse, rat, dog and human hepatocytes and had a more rapid turnover in monkey hepatocytes. Proposed metabolites from exploratory metabolite identification in vitro (rat, dog and human liver microsomes) and in vivo (dog and rat urine) include three primary oxidative metabolites (M1-M3) and three sequential glucuronides (M4-M6). Oxidative metabolites identified in microsomes M1 and M3 were formed primarily by P4503A4/5 (M1) and P4502C9 (M3). GDC-0449 was not a potent inhibitor of P4501A2, P4502B6, P4502D6, and P4503A4/5 with IC50 estimates greater than 20 microM. K(i)'s estimated for P4502C8, P4502C9 and P4502C19 and were 6.0, 5.4 and 24 microM, respectively. An evaluation with Simcyp suggests that GDC-0449 has a low potential of inhibiting P4502C8 and P4502C9. Furthermore, GDC-0449 (15 microM) was not a potent P-glycoprotein/ABCB1 inhibitor in MDR1-MDCK cells. Overall, GDC-0449 has an attractive preclinical profile and is currently in Phase II clinical trials.
High-Throughput Screening of Patient-Derived Cultures Reveals Potential for Precision Medicine in Glioblastoma (2015)

Identifying drugs for the treatment of glioblastoma (GBM), a rapidly fatal disease, has been challenging. Most screening efforts have been conducted with immortalized cell lines grown with fetal bovine serum, which have little relevance to the genomic features found in GBM patients. Patient-derived neurosphere cultures, while being more physiologically relevant, are difficult to screen and therefore are only used to test a few drug candidates after initial screening efforts. Laminin has been used to generate two-dimensional cell lines from patient tumors, preserving the genomic signature and alleviating some screening hurdles. We present here the first side-by-side comparison of inhibitor sensitivity of laminin and neurosphere-grown patient-derived GBM cell lines and show that both of these culture methods result in the same pattern of inhibitor sensitivity. We used these screening methods to evaluate the dependencies of seven patient-derived cell models: three grown on laminin and four grown as neurospheres, against 56 agents in 17-point dose-response curves in 384-well format in triplicate. This allowed us to establish differential sensitivity of chemotherapeutic agents across the seven patient-derived models. We found that MEK inhibition caused patient-sample-specific growth inhibition and that bortezomib, an FDA-approved proteasome inhibitor, was potently lethal in all patient-derived models. Furthermore, the screening results led us to test the combination of the Bcl-2 inhibitor ABT-263, and the mTOR inhibitor AZD-8055, which we found to be synergistic in a subset of patient-derived GBM models. Thus, we have identified new candidate therapeutics and developed a high-throughput screening system using patient-derived GBM samples.
Al/Ge co-doped large mode area fiber with high SBS threshold (2007)

We propose a novel approach of making large effective area laser fiber with higher threshold for the stimulated Brillouin scattering (SBS) using Al/Ge co-doping in the fiber core. The increased SBS threshold is achieved by reducing the acoustic-optic overlap integral while keeping the optical refractive index profile with a step structure. The manipulation of the overlap integral is done by adjusting the relative doping level between Al(2)O(3) and GeO(2) in the core. The mechanism is validated by detailed examples of numerical modeling. An Yb-doped double clad fiber with the core co-doped with Al(2)O(3) and GeO(2) was fabricated by the OVD process. Measured acoustic velocity profile using a scanning acoustic microscope verified that the acoustic velocity in the fiber core changes with the design. An amplifier utilizing the fiber demonstrated that the proposed fiber yielded 6 dB higher SBS threshold than a fiber without using the co-doping scheme.
A Technical Aid in Transoral Wiring of Mandibular Fractures (1984)

A technique is discussed for drilling and securing the inferior border of mandible fractures by a complete transoral approach. It simplifies the passage of interosseous wires and provides a stable fixation.
Experimental characterization and system simulations of depth of interaction PET detectors using 0.5 mm and 0.7 mm LSO arrays (2009)

Small animal PET scanners may be improved by increasing the sensitivity, improving the spatial resolution and improving the uniformity of the spatial resolution across the field of view. This may be achieved by using PET detectors based on crystal elements that are thin in the axial and transaxial directions and long in the radial direction, and by employing depth of interaction (DOI) encoding to minimize the parallax error. With DOI detectors, the diameter of the ring of the PET scanner may also be decreased. This minimizes the number of detectors required to achieve the same solid angle coverage as a scanner with a larger ring diameter and minimizes errors due to non-collinearity of the annihilation photons. In this study, we characterize prototype PET detectors that are finely pixelated with individual LSO crystal element sizes of 0.5 mm x 0.5 mm x 20 mm and 0.7 mm x 0.7 mm x 20 mm, read out at both ends by position sensitive avalanche photodiodes (PSAPDs). Both a specular reflector and a diffuse reflector were evaluated. The detectors were characterized based on the ability to clearly resolve the individual crystal elements, the DOI resolution and the energy resolution. Our results indicate that a scanner based on any of the four detector designs would offer improved spatial resolution and more uniform spatial resolution compared to present day small animal PET scanners. The greatest improvements to spatial resolution will be achieved when the detectors employing the 0.5 mm x 0.5 mm x 20 mm crystals are used. Monte Carlo simulations were performed to demonstrate that 2 mm DOI resolution is adequate to ensure uniform spatial resolution for a small animal PET scanner geometry using these detectors. The sensitivity of such a scanner was also simulated using Monte Carlo simulations and was shown to be greater than 10% for a four ring scanner with an inner diameter of 6 cm, employing 20 detectors per scanner ring.
Development of a 23S rRNA-based PCR assay for the detection of mycobacteria. (1994)

The partial nucleotide sequence of a recombinant plasmid containing the 23S rRNA gene of Mycobacterium tuberculosis was determined and an assay was developed for amplifying 23S rRNA gene sequences of mycobacteria. The PCR-based non-radioactive test enabled us to distinguish Mycobacterium from other closely related genera and was sensitive enough to detect 2 bacterial genome equivalents. The assay was extended to the detection of mycobacterial DNA in uncultured clinical specimens; 23S rRNA sequences were detected in thirty four of forty eight (70.8%) sputum and cerebrospinal fluid (CSF) specimens by the PCR assay, whereas direct smear examination and culture methods demonstrated a positivity rate of 29.2% and 16.7% respectively for the same specimens. A RNA-based PCR assay with a detection limit of 1 genome equivalent was also developed. These PCR assays should prove useful for the early and rapid detection of mycobacterial infection in uncultured clinical specimens.
Partial Hydrolysis of Soyasaponin I and the Hepatoprotective Effects of the Hydrolytic Products. Studies on the Hepatoprotective Drugs. Part IV. (Studies on the Constituents of the Leguminous Plants. Part LVII.) Study of the Structure-Hepatoprotective Relationship of Soyasapogenol B Analogs. (1998)

As a part of our studies of hepatoprotective drugs, we prepared some soyasapogenol B analogs from soyasaponin I. We examined the hepatoprotective effects of these analogs, using immunologically-induced liver injury, in primary cultured rat hepatocytes. Soyasaponin III and soyasapogenol B monoglucuronide were more effective than soyasaponin I. Both compounds were significantly effective even at 30 microM. The action of soyasapogenol B was almost equal to that of soyasaponin I, although glucuronic acid did not show any activity even at the highest dose (500 microM). When the two compounds were mixed, the hepatoprotective action did not change, compared with soyasapogenol B. Therefore, we concluded that the linkage between glucuronic acid and soyasapogenol B could enhance the hepato-protective activity.
Analysis of Machine learning Techniques Used in Behavior-Based Malware Detection (2010)

The increase of malware that are exploiting the Internet daily has become a serious threat. The manual heuristic inspection of malware analysis is no longer considered effective and efficient compared against the high spreading rate of malware. Hence, automated behavior-based malware detection using machine learning techniques is considered a profound solution. The behavior of each malware on an emulated (sandbox) environment will be automatically analyzed and will generate behavior reports. These reports will be preprocessed into sparse vector models for further machine learning (classification). The classifiers used in this research are k-Nearest Neighbors (kNN), Naïve Bayes, J48 Decision Tree, Support Vector Machine (SVM), and Multilayer Perceptron Neural Network (MlP). Based on the analysis of the tests and experimental results of all the 5 classifiers, the overall best performance was achieved by J48 decision tree with a recall of 95.9%, a false positive rate of 2.4%, a precision of 97.3%, and an accuracy of 96.8%. In summary, it can be concluded that a proof-of-concept based on automatic behavior-based malware analysis and the use of machine learning techniques could detect malware quite effectively and efficiently.
Thrombin activation and liver inflammation in advanced hepatitis C virus infection (2016)

Hepatitis C virus (HCV) infection is associated with increased thrombotic risk. Several mechanisms are involved including direct endothelial damage by the HCV virus, with activation of tissue factor, altered fibrinolysis and increased platelet aggregation and activation. In advanced stages, chronic HCV infection may evolve to liver cirrhosis, a condition in which alterations in the portal microcirculation may also ultimately lead to thrombin activation, platelet aggregation, and clot formation. Therefore in advanced HCV liver disease there is an increased prevalence of thrombotic phenomena in portal vein radicles. Increased thrombin formation may activate hepatic stellate cells and promote liver fibrosis. In addition, ischemic changes derived from vascular occlusion by microthrombi favor the so called parenchymal extinction, a process that promotes collapse of hepatocytes and the formation of gross fibrous tracts. These reasons may explain why advanced HCV infection may evolve more rapidly to end-stage liver disease than other forms of cirrhosis.
Steam-injection profile control using limited-entry perforations (1985)

A completion technique for steam injection wells that assures improved profile distribution of steam into several independent sands is being used at the South Belridge Field, California. Previously, steam profiles were poor for many of the conventionally perforated (two-3/8'' diameter holes per foot) injection wells. This standard completion does not guarantee that the thicker, higher permeability sands will not act as thief zones with respect to the thinner, tighter sands open in the same wellbore. Limited entry perforating (typically one hole per 15-20' of gross interval with at least one in each major sand member) provides the best assurance of achieving a uniform injection profile in single wellbore multi-sand completions.