gebhart/patrepeval huggingface dataset:
Selective agonists for receptors of substance P and related neurokinins (1989)

Neurokinins and their receptors are a complex system consisting of at least three endogenous agents--substance P (SP), neurokinin A (NKA), and neurokinin B (NKB)--and their corresponding receptor types, respectively, NK-1, NK-2, and NK-3. Investigations on receptors have been made using sensitive and fairly selective pharmacological preparations (the dog carotid artery for the NK-1, the rabbit pulmonary artery devoid of endothelium for the NK-2, and the rat portal vein for the NK-3 receptor), and some natural peptides of mammalian and nonmammalian origin. Because of the nonselectivity of the natural peptides, analogues of the neurokinins have been found that act on one receptor only and show therefore high selectivity. The selective agonists [Sar9,Met(O2)11]SP, [Nle10]NKA (4-10), and [MePhe7]-NKB have been used successfully for (a) characterizing the three neurokinin receptors, (b) identifying isolated organs whose responses to neurokinins depend on the activation of a single (monoreceptor systems) or of more than one (multireceptor systems) receptor, and (c) elucidating some of the physiological function of the three receptor types. It is suggested that NK-1 mediate peripheral vasodilatation and exocrine secretions, NK-2 stimulate bronchial muscles and facilitate the release of catecholamines, and NK-3 promote the release of acetylcholine in peripheral organs.
Small interfering RNA against PTTG: A novel therapy for ovarian cancer (2007)

Ovarian epithelial cancer is a significant cause of death among women, accounting for 5% of all female cancer-related fatalities. A lack of reliable detection methods and resistance to chemotherapy agents are considerable obstacles in the treatment of this cancer. Recently, high-level expression of the pituitary tumor transforming gene (PTTG) was found in a wide range of tumors, including ovarian cancers. Elevated PTTG levels were found to induce cellular transformation in vitro and tumor formation in nude mice. Therefore, we hypothesize a correlation exists between the levels of PTTG expression and tumorigenesis, and that down-regulation of PTTG levels will result in the suppression of tumor growth. We used small interfering RNA (siRNA) to silence PTTG expression in human A2780 ovarian carcinoma cells and assessed the effect of PTTG silencing in tumor formation in vitro and in vivo. The siRNA directed against PTTG reduced its expression at both the mRNA and protein levels. A fifty percent reduction in cell proliferation was achieved in cells constitutively expressing PTTG siRNA compared to vector or control-siRNA transfected cells. Furthermore, colony formation in soft agar was reduced by 70% in PTTG siRNA stable cell lines. Using nude mice, we showed that animals injected with A2780 cells constitutively expressing PTTG-siRNA decreased the incidence of tumor development and tumor growth. Taken together, these results strongly suggest that PTTG may serve as an important molecular target for the discovery of new anticancer agents and treatment strategies.
Immunogenicity of a bovine rotavirus glycoprotein fragment (1985)

Previous experiments demonstrated that an antigenic site responsible for virus neutralization and cell attachment was located on a 14,000-molecular-weight fragment of the major bovine rotavirus (BRV) glycoprotein (M. Sabara, J. E. Gilchrist, G. R. Hudson, and L. A. Babiuk, J. Virol. 53:58-66, 1985). However, it was necessary to investigate whether this fragment also had the ability to induce the production of neutralizing antibodies. Upon immunization of mice, the bovine serum albumin-conjugated 14,000-molecular-weight fragment, the unconjugated 14,000-molecular-weight fragment, and the native glycoprotein all induced a similar neutralizing antibody response, albeit to a lesser extent than did the infectious, whole virus. In addition, immuno-blot enzyme-linked immunosorbent assay analysis of the reactivity of anti-peptide serum versus anti-glycoprotein serum with the glycoprotein was very comparable. These results suggest that the 14,000-molecular-weight fragment may represent not only a biologically active region but also an immunodominant area of the glycoprotein.
DISTRIBUTION AND RELATIVE ABUNDANCE OF SMALL MAMMALS IN THE ILLINI FOREST PLANTATION, URBANA, ILLINOIS (1978)

The abundance and distribution of small mammals were analyzed for correlation with the vegetational characteris· tics of their habitat. Positive correlations were found for the number of mammals trapped per area trapped versus the total ground cover (r= .67, P< .05) and for the number of mammal species versus total ground cover (r= .73, P<.05). The habitat preferences of the three species trapped (short-tailed shrews B/,arina brevicauda. white-footed mice Peromyscus leucopuus, and meadow voles Microtus pennsylvanicus) showed a distinct distributional pattern for the species in relation to their habitats. The management of forest-tree plantations to achieve high densities during the seedling stage and the use of silvicultural practices that promote high shrub densities are suggested as inexpensive and natural control measures for injurious microtine rodents. Seedlings must be permitted to reach a sufficient height to remove the risk of the shrubs overtopping them.
Urban human mobility data mining: An overview (2016)

Understanding urban human mobility is crucial for epidemic control, urban planning, traffic forecasting systems and, more recently, various mobile and network applications. Nowadays, a variety of urban human mobility data have been gathered and published. Pervasive GPS data can be collected by mobile phones. A mobile operator can track people's movement in cities based on their cellular network location. This urban human mobility data contains rich knowledge about locations and can help in addressing many urban challenges such as traffic congestion or air pollution problems. In this article, we survey recent literature on urban human mobility from a data mining view: from the data collection and cleaning, to the mobility models and the applications. First, we summarize recent public urban human mobility data sets and how to clean and preprocess such data. Second, we describe recent urban human mobility models and predictors, e.g., the deep learning predictor, for predicting urban human mobility. Third, we describe how to evaluate the models and predictors. We conclude by considering how applications can utilize the mobility models and predictive tools for addressing city challenges.
Proof of concept study with an HER-2 mimotope anticancer vaccine deduced from a novel AAV-mimotope library platform (2016)

In this study, a novel mimotope AAV-based platform was created allowing the isolation of mimotopes, which can be directly used as anticancer vaccines. The example of trastuzumab AAV-mimotopes demonstrates that this vaccine strategy could help to establish active immunotherapy for breast-cancer patients.
Development of Tunable Optical Filters for Interrogation of White-Light Interferometric Sensors (2005)

Interferometric fiber optic sensors have been extensively used to measure a large variety of physical, chemical and biomedical parameters due to their superior performance. At the Center for Photonics Technology of Virginia Tech, a variety of interferometric fiber optic sensors have been developed in recent years, for efficient oil recovery, partial discharge detection in high voltage transformers, pressure sensing in gas turbine engines, and temperature measurements in gasifiers and boilers. However, interrogating an interferometric sensor involves accurate recovery of a measurand from the phase-modulated lightwaves, and has been a challenge for high performance, high speed, and low-cost, to current white-light interferometry (WLI) techniques, such as the widely used scanning WLI (S-WLI) and spectral-domain WLI (SD-WLI). The performance of a white-light interferometric sensing system depends not only on the design of the probes, but also, to a great extent, on the interrogation strategy to be used. In this Ph.D. research, a tunable optical filter based WLI (TOF-WLI) is proposed and validated as a low cost, yet high performance, solution to the interrogation of various types of interferometric sensors. In addition to the capability of linear/quadrature demodulation, TOF-WLI retains all the features of WLI, is compatible with the SD-WLI, and can be tailored for both static and wideband signals. It also has great potential in surface metrology and biomedical imaging as well as optical spectroscopy. The key, to the success of this new approach in competition with the other available WLI techniques, is that the tunable optical filter (TOF) must be specially designed for sensing and extremely low cost. Therefore, two novel TOFs, a diffraction grating tunable filter (DG-TOF) and an extrinsic Fabry-Perot tunable filter (EFP-TF), are proposed and demonstrated. Laboratory and field test results on using the DG-TOF WLI for partial discharge and thermal fault detection in high voltage power transformers, and the EFP-TF WLI in temperature sensor systems and a turbine engine monitoring system will also be presented to demonstrate the feasibility for efficient sensor interrogation.
QoE-Aware OTT-ISP Collaboration in Service Management (2018)

It is a matter of fact that quality of experience (QoE) has become one of the key factors determining whether a new multimedia service will be successfully accepted by the final users. Accordingly, several QoE models have been developed with the aim of capturing the perception of the user by considering as many influencing factors as possible. However, when it comes to adopting these models in the management of the services and networks, it frequently happens that no single provider has access to all of the tools to either measure all influencing factors parameters or control over the delivered quality. In particular, it often happens to the over-the-top (OTT) and Internet service providers (ISPs), which act with complementary roles in the service delivery over the Internet. On the basis of this consideration, in this article we first highlight the importance of a possible OTT-ISP collaboration for a joint service management in terms of technical and economic aspects. Then we propose a general reference architecture for a possible collaboration and information exchange among them. Finally, we define three different approaches, namely joint venture, customer lifetime value based, and QoE fairness based. The first aims to maximize the revenue by providing better QoE to customers paying more. The second aims to maximize the profit by providing better QoE to the most profitable customers (MPCs). The third aims to maximize QoE fairness among all customers. Finally, we conduct simulations to compare the three approaches in terms of QoE provided to the users, profit generated for the providers, and QoE fairness.
Sampling minimal frequent boolean (DNF) patterns (2012)

We tackle the challenging problem of mining the simplest Boolean patterns from categorical datasets. Instead of complete enumeration, which is typically infeasible for this class of patterns, we develop effective sampling methods to extract a representative subset of the minimal Boolean patterns (in disjunctive normal form - DNF). We make both theoretical and practical contributions, which allow us to prune the search space based on provable properties. Our approach can provide a near-uniform sample of the minimal DNF patterns. We also show that the mined minimal DNF patterns are very effective when used as features for classification.
Storage management for knowledge bases (1993)

Secondary memory storage plays a major role in making large knowledge bases usable. This paper presents such a storage architecture for knowledge bases. In particular, the Controlled Decomposition Model, a flexible storage model which takes into account the numerous and expressive features of the knowledge representation model is defined.
Synthesis and Characterization of 2D Molybdenum Carbide (MXene) (2016)

Large scale synthesis and delamination of 2D Mo 2 CT x (where T is a surface termination group) has been achieved by selectively etching gallium from the recently discovered nanolaminated, ternary transition metal carbide Mo 2 Ga 2 C. Different synthesis and delamination routes result in different flake morphologies. The resistivity of free‐standing Mo 2 CT x films increases by an order of magnitude as the temperature is reduced from 300 to 10 K, suggesting semiconductor‐like behavior of this MXene, in contrast to Ti 3 C 2 T x which exhibits metallic behavior. At 10 K, the magnetoresistance is positive. Additionally, changes in electronic transport are observed upon annealing of the films. When 2 μm thick films are tested as electrodes in supercapacitors, capacitances as high as 700 F cm −3 in a 1 m sulfuric acid electrolyte and high capacity retention for at least 10,000 cycles at 10 A g −1 are obtained. Free‐standing Mo 2 CT x films, with ≈8 wt% carbon nanotubes, perform well when tested as an electrode material for Li‐ions, especially at high rates. At 20 and 131 C cycling rates, stable reversible capacities of 250 and 76 mAh g −1 , respectively, are achieved for over 1000 cycles.
Cardiovascular Responses to the Isoprostanes iPF<sub>2α</sub>-III and iPE<sub>2</sub>-III Are Mediated via the Thromboxane A<sub>2</sub>Receptor In Vivo (2000)

Both iPF(2alpha)-III and iPE(2)-III exert their effects on platelet function and vascular tone in vivo by acting as incidental ligands at membrane TPs rather than via a distinct iP receptor. Activation of TPs by iPs may be of importance in syndromes in which cyclooxygenase activation and oxidant stress coincide, such as in atherosclerosis and reperfusion after tissue ischemia.
Non-Neurotic Neurotics (1968)

A non-neurotic neurotic is a patient with organic disease misdiagnosed as an emotional illness. Among conditions discussed here that cause non-neurotic neuroses are Addison's disease, hypoglycemia, hyperthyroidism, myxedema, Cushing's disease, porphyria, pernicious anemia, pancreatic carcinoma, and brain tumors. Supposed psychiatric disease, then, can be organic disease with a nervous mask.
Physical and Functional Interactions between Pathogen-Induced <i>Arabidopsis</i> WRKY18, WRKY40, and WRKY60 Transcription Factors (2006)

Limited information is available about the roles of specific WRKY transcription factors in plant defense. We report physical and functional interactions between structurally related and pathogen-induced WRKY18, WRKY40, and WRKY60 transcription factors in Arabidopsis thaliana. The three WRKY proteins formed both homocomplexes and heterocomplexes and DNA binding activities were significantly shifted depending on which WRKY proteins were present in these complexes. Single WRKY mutants exhibited no or small alterations in response to the hemibiotrophic bacterial pathogen Pseudomonas syringae and the necrotrophic fungal pathogen Botrytis cinerea. However, wrky18 wrky40 and wrky18 wrky60 double mutants and the wrky18 wrky40 wrky60 triple mutant were substantially more resistant to P. syringae but more susceptible to B. cinerea than wild-type plants. Thus, the three WRKY proteins have partially redundant roles in plant responses to the two distinct types of pathogens, with WRKY18 playing a more important role than the other two. The contrasting responses of these WRKY mutants to the two pathogens correlated with opposite effects on pathogen-induced expression of salicylic acid-regulated PATHOGENESIS-RELATED1 and jasmonic acid-regulated PDF1.2. While constitutive expression of WRKY18 enhanced resistance to P. syringae, its coexpression with WRKY40 or WRKY60 made plants more susceptible to both P. syringae and B. cinerea. These results indicate that the three WRKY proteins interact both physically and functionally in a complex pattern of overlapping, antagonistic, and distinct roles in plant responses to different types of microbial pathogens.
Primary Structure of <i>Lep D</i> I, the Main <i>Lepidoglyphus Destructor</i> Allergen (1994)

The most relevant allergen of the storage mite Lepidoglyphus destructor (Lep d I) has been characterized. Lep d I is a monomer protein of 13273 Da. The primary structure of Lep d I was determined by N-terminal Edman degradation and partially confirmed by cDNA sequencing. Sequence polymorphism was observed at six positions, with non-conservative substitutions in three of them. No potential N-glycosylation site was revealed by peptide sequencing. The 125-residue sequence of Lep d I shows approximately 40% identity (including the six cysteines) with the overlapping regions of group II allergens from the genus Dermatophagoides, which, however, do not share common allergenic epitopes with Lep d I.
Low Voltage Class-E Power Amplifiers for DECT and Bluetooth in 130nm CMOS (2009)

This paper presents the design of two low- voltage differential class-E power amplifiers (PA) for DECT and Bluetooth fabricated in 130 nm CMOS. In order to minimize the on-chip losses and to achieve a high efficiency at low supply voltages, the PAs do not use on-chip output matching networks. At 1.5V supply voltage, the DECT PA delivers +26.4 dBm of output power with a drain efficiency (DE) and power-added efficiency (PAE) of 41% and 30%, respectively. The Bluetooth PA delivers +22.7 dBm at IV with a DE and PAE of 48% and 36%, respectively. A continuous long-term test of 100 hours proves the reliability of the design.
Adaptation of mammalian protein metabolism to amino acid supply (1969)

Laboratorie8, Departnent of Nutrition and
Distance: A Moderator Between Walking Activity and Pattern Classification (2012)

The research of this paper is to investigate does distance will affecting the walking activity and the pattern for classification. This paper built a comprehensive picture of the human walking activity, programming language, workflow of the tool, features extraction and patterns classification method and captured the attitudes of the respondents. The subject was performed a range of walking activity in a controlled laboratory setting. The result of this study shows that the moderating effects of walking distance explains 15.80% (Gyroscope), 74.60% (Accelerometer) and 98.60% (Compass) of variance in research output. The result is expected to be beneficial and able to assist researchers and medical officers in analyzing human motion and its pattern classification.
Ginseng and Memory (1998)

For thousands of years, Chinese medicine has used the herb ginseng as a memory tonic with the belief that ginseng can improve learning and memory, especially in aging humans. Recent studies have sought to validate this claim. Experiments done on rats have shown that ginsenosides, the saponins of ginseng, can partially prevent scopolamine-induced memory deficits in rats. Ginsenosides are thought to increase choline uptake in the central cholinergic nervous system, which plays important roles in learning and memory. Further experiments have shown that ginseng extracts can improve the retention of learned behavior in young (aged 3 months) as well as old (aged 26 months) rats. The potential beneficial effects of the polysaccharide fractions of ginseng on learning and memory still warrant further experimentation. The favorable effects of ginseng on learning and memory make it a promising drug for the use in geriatric practice.
The Use of Custom‐Milled Zirconia Teeth to Address Tooth Abrasion in Complete Dentures: A Clinical Report (2012)

A patient exhibited severe abrasion of resin posterior denture teeth including perforation of the denture base. New dentures were provided to explore the application of zirconia teeth for complete dentures. [Correction added to online publication 07 November 2012: "Zirconium" corrected to "Zirconia".] Traditional denture procedures were combined with fixed prosthodontic CAD/CAM procedures to fabricate custom-designed four-tooth posterior segments in hollow crown form to reduce weight and with a retentive form for interlocking to the denture base. The new dentures were successful in reducing wear of the denture teeth over the short-term follow-up period.
[Intracellular ph and the substrate dependence of Chinese hamster fibroblast proliferation]. (1991)

Data have been presented on the effect of serum and of cell adhesion to a solid substrate on the intracellular pH (pHi) value in anchorage-dependent Chinese hamster fibroblasts. Proliferation of cells was observed in a pHi range from 7.0 to 7.5, which exceeded by 0.3-0.4 the pHi of quiescent cells. It was shown that attachment and spreading of cells in a bicarbonate-containing media without serum produced elevation of pHi from 6.7 to 7.1 but did not provide such an alkalization value for times greater than the lag period of cell growth. By the end of the first day after plating the pHi value of the spread cells in a serum-free medium reduced to 6.75, and the cells ceased to grow. The serum without cell attachment produced only a short-time (less than 1 h) pHi increase from 6.7 to 6.88, which was inadequate for cell growth. However, the serum produced a prolongation in cytoplasm alkalization characteristic of proliferation and caused by attachment of cells to a solid substrates. Evidence also was obtained for the absence of Na-independent HCO3-/Cl- exchange, the presence of a slow HCO3- transport into the cell and the key role of Na+/H+ exchange in pHi regulation. Addition to the bicarbonate-containing medium of amiloride, a blocker of Na+/H+ exchange, resulted in acidification of the cytoplasm to 6.5, and inhibited cell attachment and proliferation.
On a Theory of the van der Waals Adsorption of Gases (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn a Theory of the van der Waals Adsorption of GasesStephen Brunauer, Lola S. Deming, W. Edwards Deming, and Edward TellerCite this: J. Am. Chem. Soc. 1940, 62, 7, 1723–1732Publication Date (Print):July 6, 1940Publication History Published online1 May 2002Published inissue 6 July 1940https://pubs.acs.org/doi/10.1021/ja01864a025https://doi.org/10.1021/ja01864a025research-articleACS PublicationsRequest reuse permissionsArticle Views10594Altmetric-Citations3933LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Three types of health education. (1980)

Abstract: Types of health in Britain may be categorized as personal physical health and maintenance, the use of health care resources, and the importance of the environment to public health. The latter category is relevant to policy-making in many areas: public transport, agriculture, economic growth, smoking (and tax revenues), job safety, etc. While national policy should be based on and be responsive to these concerns, the community development approach to health education, as practiced recently in developing countries and in the U.S., must not be overlooked. Public health programs must involve social change and overcoming the status quo; this process is sometimes impeded by the psuedo-health education of commercial enterprises. The interests of the public would best be served through integration of all 3 types of health education.