gebhart/patrepeval huggingface dataset:
Running Interference for Hedgehog Signaling (2003)

The new technology of RNA interference (RNAi) is allowing high-throughput screening of cells to examine many biological processes. Michelson discusses one such system in which the Drosophila Hedgehog (Hh) pathway was analyzed by systematic genome-wide RNAi analysis. The results not only suggest unexpected overlap in the Hh and Wingless (Wg) pathways, but also provide proof of principle for the development of high-throughput assays using RNAi techniques.
Optical properties of native and coagulated human liver tissue and liver metastases in the near infrared range (1998)

A greater optical penetration depth in metastatic tissue is advantageous for LITT, since larger tumor volumes can be coagulated. At the same time, an adjustment of the application parameters during LITT is necessary to achieve optimal therapeutic success.
DCCP-UDP: A Datagram Congestion Control Protocol UDP Encapsulation for NAT Traversal (2012)

This document specifies an alternative encapsulation of the Datagram Congestion Control Protocol (DCCP), referred to as DCCP-UDP.This encapsulation allows DCCP to be carried through the current generation of Network Address Translation (NAT) middleboxes without modification of those middleboxes.This document also updates the Session Description Protocol (SDP) information for DCCP defined in RFC 5762.
Comparison of rigid and semi-rigid instrumentation under acute load on vertebrae treated with posterior lumbar interbody fusion/transforaminal lumbar interbody fusion procedures: An experimental study (2018)

Rigid and semi-rigid fixations are investigated several times in order to compare their biomechanical stability. Interbody fusion techniques are also preferable for maintaining the sagittal balance by protecting the disk height. In this study, the biomechanical comparison of semi-rigid and rigid fixations with posterior lumbar interbody fusion or transforaminal lumbar interbody fusion procedures is conducted under trauma. There were four different test groups to analyze the effect of acute load on treated ovine vertebrae. First and second groups were fixed with polyetheretherketone rods and transforaminal lumbar interbody fusion and posterior lumbar interbody fusion cages, respectively. Third and fourth groups were fixed with titanium rods and posterior lumbar interbody fusion and transforaminal lumbar interbody fusion cages, respectively. The drop tests were conducted with 7 kg weight. There were six samples in each group so the drop test repeated 24 times in total. The test samples were photographed and X-rayed (laterally and anteroposteriorly) before and after drop test. Two fractures were observed on group 1. Conversely, there were no fractures observed for group 2. There were no anterior element fractures for both groups 1 and 2. However, one fracture seen on group 3 was anterior element fracture, whereas the other three were posterior element fractures. All three fractures were anterior element fractures for group 4. Treated vertebrae with polyetheretherketone rods and posterior lumbar interbody fusion cages showed the best durability to the drop tests among the groups. Semi-rigid fixation gave better results than rigid fixation according to failed segments. Posterior lumbar interbody fusion cages seem to be better option for semi-rigid fixation, however mentioned surgical disadvantages must be considered.
Left Atrial Appendage Occlusion — Closure or Just the Beginning? (2009)

More than 3 million Americans have atrial fibrillation, which increases their risk of stroke by a factor of 5.1,2 Patients with atrial fibrillation account for one of every six strokes, and thromboemboli originating from the left atrial appendage are the suspected culprit in the vast majority of these cases.1,2 Warfarin, a vitamin K antagonist, is the most commonly prescribed treatment for stroke prevention in patients with atrial fibrillation; yet despite warfarin's proven benefit, its effective delivery is challenged by a narrow therapeutic window and an increased risk of bleeding. Efforts have been made to develop alternative treatment strategies . . .
Highly Efficient Bilayer Interface Exciplex For Yellow Organic Light-Emitting Diode (2013)

A simple three-layer interfacial-type yellow emission exciplex device with an external quantum efficiency as high as 7.7% has been successfully achieved by combining conformation compatible C3-symmetric hole-transporting TCTA and electron-transporting 3P-T2T. The excellent and balanced charge-transporting properties of TCTA and 3P-T2T and the large energy-levels offset (0.8 eV) of TCTA/3P-T2T interface play important roles for the efficient exciplexes formation, which are effectively confined around the interfacial region due to the high triplet energies (2.85 eV) of TCTA and 3P-T2T. The high-performance OLED was believed to be from the effective harvest of exciplex triplet excitons via reverse intersystem crossing process.
Application of gold nanoparticle self-assemblies to unclonable anti-counterfeiting technology (2015)

Counterfeits are now world-wide issue. An anti-counterfeit technology with high security level (unclonable), high through-put rate of authentication, and low cost is desirable. Nanotag of plasmonic nanostructure with surface enhanced Raman scattering (SERS) activity is promised for the ideal authentication. The gold nanoparticle (AuNP) self-assemblies were applied to SERS active “stealth nanobeacon” for authentication. Mild deposition of aqueous dispersion of self-assembled AuNP was used. 10 ng AuNP assemblies deposited on a commercial medicine tablet were almost invisible to the eye. Distinguishable SERS signals of reporting molecules was produced by 1s irradiation of 785 nm laser over the nanobeacon, while Raman spectrum of the ingredients was observed on the tablet without the nanobeacon. Rapid authentication of tablets stocked for 60 days was sufficiently carried out. It is considered that the presence of discrete AuNP assemblies allows excellent performances of stealth nanobeacon.
Identification and quantitation ofN-(carboxymethyl)valine adduct in hemoglobin by gas chromatography/mass spectrometry (1999)

A sensitive, specific and reproducible method was developed for the quantitation of the hemoglobin (Hb) adduct N-(carboxymethyl)valine (CMV). This adduct is one of various products from the Maillard reaction, involving reducing sugars and amino acids, proteins or other molecules with a free amino group. Such adducts, including N epsilon-(carboxymethyl)lysine (CML), are called advanced glycation end products (AGE) and have been correlated with aging and severity of diabetes in human tissues. This method was developed to examine the CMV-Hb adduct as a possible AGE formed by reaction of Hb with glucose or other oxidation products. CMV was cleaved selectively from isolated globin using pentafluorophenyl isothiocyanate (PFPITC) in a modified Edman degradation at pH 9.5. The carboxyl group of the adduct was derivatized to its methyl ester with diazomethane. The resulting derivative, 5-isopropyl-1-(methyl acetate)-3-pentafluorophenyl-2-thiohydantoin, was detected by gas chromatography/mass spectrometry with selected ion monitoring (GC/SIM/MS). Quantitation was based on the response factor of the derivative molecular ion (m/z 396) from synthesized CMV and N-(2-carboxyethyl)valine (molecular ion m/z 410) as internal standard. This method exhibits reproducibility and linearity in the range 0.2-100 ng CMV. The limit of quantitation (0.2 ng CMV) gave a signal-to-noise ratio greater than 5:1 using a 1:30 sample aliquot. The GC/SIM/MS method can detect CMV adduct in 5 mg globin samples with relative standard deviations less than 5%. This approach avoids tedious acid hydrolysis and interference from other amino acids. The molecular ion and other CMV derivative ion assignments from samples were confirmed by accurate mass determinations using GC/high resolution SIM/MS. Measurements from random mouse, rat and human globin samples gave mean CMV levels of about 6, 5 and 14 nmol g-1 Hb in these species, respectively.
Design of a Glass Stair (2010)

This paper discusses unique design and construction issues of a glass stair, which comprises of a custom made stainless steel elliptical shaped stringer, glass treads and glass balustrade. State-of the-art finite element analyses were performed to ensure that the stresses at the interface of the glass-stainless steel pieces were within allowable limits. Furthermore, dynamic footfall analyses were performed to ensure that vibration due to walking activity was within an acceptable limit of human comfort. Finally, manufacturing and erection of the glass stair had unique features due to the brittle nature of glass.
Expression of a transformation-related protein (p53) in the malignant stage of Friend virus-induced diseases (1983)

Stage 1 (pre-malignant) and stage 2 (malignant) cells derived from mice infected with Friend murine leukemia virus or polycythemia-inducing Friend virus complex were examined and compared for the expression of a transformation-related cellular protein, p53. Stage 2 cells were found to express high levels of p53, whereas stage 1 cells did not express detectable levels of this protein. These results indicate that p53 may be a marker for transformed cells present in the second stage of diseases induced by Friend murine leukemia virus or polycythemia-inducing Friend virus complex.
Morphometry of the Human Pulmonary Arterial Tree (1973)

From a cast of a human pulmonary arterial tree, the diameter, length, order, and end branches of all intact branches down to those 0.8 mm in diameter were measured and corrections for broken branches were made. A sample of structures smaller than these (0.8-0.1 mm) was similarly measured. The values for branches less than 0.1 mm in diameter were found by extrapolation and comparison with known data for the precapillary vessels. Therefore, data or estimates for each order of branching in the pulmonary tree were obtained and calculations of cross-sectional area, volume, and flow were made.
Principle Component Analysis (2006)

In this chapter, we first describe some basic concepts of PCA, a useful statistical technique that can be used in many fields, such as face patterns and other biometrics. Then, we introduce PCA definitions and related technologies. Following, we discuss non-linear PCA technologies. Finally, some useful conclusions are summarized.
Inhibition of Protein Kinase C Prevents Purkinje Cell Death But Does Not Affect Axonal Regeneration (2002)

In organotypic cultures, mouse Purkinje cells regenerate their axons from embryonic day 18 (E18) to postnatal day 0 (P0), die of apoptosis between P1 and P7, and survive but do not regenerate at P10. This particular behavior of Purkinje cells did not allow us to find out when the developmental switch between regeneration and lack of regeneration occurs. This work was undertaken to suppress Purkinje cell apoptosis and to investigate whether the same molecules that prevent apoptosis could also influence axonal growth, regeneration, or both. We show that brain-derived neurotrophic factor, neurotrophin 3, and insulin-like growth factor I have marginal effects on P3 Purkinje cell death. The use of Gö6976 [a protein kinase C (PKC) inhibitor] or a transgenic mouse line, in which a pseudosubstrate PKC inhibitor has been specifically targeted to Purkinje cells, prevents the massive Purkinje cell death in P3 organotypic cultures. In addition, Gö6976 promotes axotomized Purkinje cell survival up to P7. Thus, the inhibition of PKC activity is able to prevent Purkinje cell apoptosis in organotypic cultures. Furthermore, Gö6976 increases the outgrowth of dendrites and axon collateralization, as shown after gene gun enhanced green fluorescent protein transfection. In contrast, PKC inhibitors do not influence the axonal regenerative capability of Purkinje cell during development; the latter decreases between E18 and P7 after the same time course in control and Gö6976-treated slices. Thus, because inhibition of PKC prevents Purkinje cell death but does not affect axonal regeneration, these two events (cell death and axonal regeneration) seem to be differentially regulated.
Proposal for almost noise-free optical communication under conditions of high background (1984)

By making use of the fact that photons are created in pairs in the process of parametric downconversion and by detecting them in coincidence, we propose a scheme for communication by light that should make it possible to achieve high discrimination against background. Weak light beams that are greatly overshadowed by background light should therefore be usable for an optical channel.
<i>Burkholderia pseudomallei</i>,<i>B. thailandensis</i>, and<i>B. ambifaria</i>Produce 4-Hydroxy-2-Alkylquinoline Analogues with a Methyl Group at the 3 Position That Is Required for Quorum-Sensing Regulation (2008)

4-Hydroxy-2-alkylquinolines (HAQs), especially 3,4-dihydroxy-2-heptylquinoline (Pseudomonas quinolone signal) and its precursor, 4-hydroxy-2-heptylquinoline, are attracting much attention, mainly because of their role as signaling molecules in Pseudomonas aeruginosa. The pqsABCDE operon is centrally involved in their biosynthesis. The presence of a homologous operon in Burkholderia pseudomallei and B. thailandensis was recently reported. Thus, we have investigated the abilities of 11 Burkholderia species to produce HAQ-like molecules by liquid chromatography/mass spectrometry. We have identified 29 different HAQ derivatives produced by the only three Burkholderia species where a pqsABCDE homologue was found among available sequenced Burkholderia species genomes, including B. ambifaria, a member of the Burkholderia cepacia complex. In contrast with those of P. aeruginosa, Burkholderia HAQs typically bear a methyl group, hence their designation as 4-hydroxy-3-methyl-2-alkylquinolines (HMAQs). We identified three families of HMAQs with a saturated or unsaturated alkyl chain at the 2' position, in contrast with the 1' position of P. aeruginosa, including one with an N-oxide group. Furthermore, the operon in these species contains two more genes downstream of the pqsE homologue, resulting in the hmqABCDEFG operon. While the inactivation of hmqA inhibits the production of HMAQs, the methylation of the quinoline ring requires a putative methyltransferase encoded by hmqG. Interestingly, hmqA or hmqG mutations increase the production of acyl homoserine lactones and, consequently, phenotypes under the control of quorum sensing in B. ambifaria: antifungal activity, siderophore production, and proteolytic activity. These results indicate that only HAQs bearing a methyl group (HMAQs) are involved in quorum-sensing regulation.
Cryopreservation of the cells and larvae of marine organisms (2012)

This paper reviews original and literature data on the cryoresistance of the cells of marine organisms. The technology for the cryopreservation of these objects includes the selection of freezing conditions and the use, in addition to traditional cryoprotectants, of combinations of exogenous lipids, antioxidants, and disaccharide trehalose as a membrane stabilizing agent. We propose an approach for the preservation of marine invertebrate cells. The approach is based on the use of biologically active substances obtained from the tissues of marine organisms. Our results demonstrated the synergistic activity of these components of cryoprotective mixtures, and, at the same time, the specificity of antioxidant effects. An analysis of the factors that determine the choice of cryoprotectors was performed for various cell types. The development of the cryopreservation methods of marine organisms provides an opportunity for their wide application in both developmental biology and in marine biotechnology and serves as an important prerequisite for the cryobank creation.
A trapped polymer chain in random porous media (1987)

Dynamic and static properties of a polymer chain without self-excluded volume, which performs Brownian motion between randomly distributed impenetrable fixed obstacles, have been investigated by Monte Carlo simulations and analyzed by scaling considerations. The mean square radius of gyration 〈S2〉, the center-of-mass diffusion coefficient D, and the longest relaxation time τ are functions of x=(1−p)(N)1/2 for all chain lengths N and porosities p above the percolation threshold. Simulations have been performed for x≲10. With increasing x the radius of gyration exhibits a crossover from Gaussian statistics 〈S2〉∼N to a collapsed state where 〈S2〉 is independent of N. This phenomenon is attributed to the effects of both the lack of self-excluded volume and the presence of an effective self-attractive potential arising from random repulsion between polymer and the solid particles of the medium. The strong dependency upon chain length of D∼N−2.9±0.3 and τ∼N4.0±0.4 is conjectured to result from randomly distributed bottlenecks and traps in the porous solid. If these local constraints are released by arranging the obstacles in a periodic array, familiar reptation dynamics and 〈S2〉∼N are observed.
High-Performance Concrete Incorporating Rice Husk Ash as a Supplementary Cementing Material (1996)

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Is There a Bandwagon Vote? (1940)

Analyzing poll data collected by the American Institute of Public Opinion, the authors deny that the polls exert a “bandwagon” influence on the opinions of the voting electorate. Mr. Gallup, of course, is Director of the Institute. Mr. Rae is associated with him, after work in the public opinion field in England, especially at Oxford University.
The Deposition and Characterization of Mo/CuInGaSe2/CdS/ZnO Solar Cells (2001)

Mo thin films were deposited on sodalime glass (SLG) substrates using direct-current planar magnetron sputtering, with a sputtering power density of 1.18 W/cm2. The working gas (Ar) pressure was varied from 0.6 mtorr to 16 mtorr to gain a better understanding of the effect of sputtering pressure on the morphology and microstructure of the Mo. Thin films of Cu(In,Ga)Se2 (CIGS) were deposited on the Mo-coated glass using the 3-stage coevaporation process. The morphology of both the Mo-coated SLG and the CIGS thin films grown on it was examined using high-resolution scanning electron microscopy. The film microstructure, such as the preferred orientation, and the residual intrinsic stress were examined by X-ray diffraction.
Computer-Assisted Instruction in Pronunciation for Chinese Speakers of American English (1988)

This article represents a synthesis of concepts from contrastive phonology, speech processing, TESOL, and computer-assisted instruction for the purpose of improving the communication skills of international teaching assistants in U.S. colleges and universities. Although the focus is on speakers of Chinese, most of the concepts are equally applicable to speakers of other East Asian languages. Methods of interpreting and utilizing visual displays of speech patterns are presented throughout, with examples of both segmental and suprasegmental phonology. Recent research in electrical engineering to produce voiceactivated machinery has resulted in the production of many efficient and low-cost machines for analyzing pronunciation. This article presents the results of 4 years of research at Rensselaer Polytechnic Institute in the application of such machines to language education. The research was prompted by the need to improve the communication skills of international teaching assistants. In the face of the large and growing proportion of international students and the limitations on ESL programs, effective teaching of pronunciation is emerging as an important goal for the needs of these students as well as those of academic institutions. Because we still have no widely standardized entrance examination of pronunciation, many high-quality international students with reasonable vocabularies and grammar are admitted to universities, even though their pronunciation of English makes them difficult to understand. Though the focus in this article is on the needs of Chinese students, most of the concepts are equally applicable to speakers of other East Asian languages, especially Japanese and Korean. Mandarin Chinese was chosen as the Li because of its strong
Syntheses, structures, and mechanism of formation of trans-chlorohydrobis(trimethylphosphine)platinum(II) and trans-dihydrobis(trimethylphosphine)platinum(II). Energetics of cis-trans isomerization (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses, structures, and mechanism of formation of trans-chlorohydrobis(trimethylphosphine)platinum(II) and trans-dihydrobis(trimethylphosphine)platinum(II). Energetics of cis-trans isomerizationDiane L. Packett, Craig M. Jensen, Robert L. Cowan, Charles E. Strouse, and William C. TroglerCite this: Inorg. Chem. 1985, 24, 22, 3578–3583Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://doi.org/10.1021/ic00216a020RIGHTS & PERMISSIONSArticle Views310Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (824 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Effects of topical nonsteroidal antiinflammatory drugs on the expression of matrix metalloproteinases in the cornea (2003)

This study provides preliminary evidence that topical application of some NSAIDs can induce the early expression of MMP-1, MMP-2, and MMP-8 in the cornea, suggesting that MMPs play a role in the corneal cytotoxicity of certain NSAIDs.
RNA remodeling and gene regulation by cold shock proteins (2010)

One of the many important consequences that temperature down-shift has on cells is stabilization of secondary structures of RNAs. This stabilization has wide-spread effects, such as inhibition of expression of several genes due to termination of their transcription and inefficient RNA degradation that adversely affect cell growth at low temperature. Several cold shock proteins are produced to counteract these effects and thus allow cold acclimatization of the cell. The main RNA modulating cold shock proteins of E. coli can be broadly divided into two categories, (1) the CspA family proteins, which mainly affect the transcription and possibly translation at low temperature through their RNA chaperoning function and (2) RNA helicases and exoribonucleases that stimulate RNA degradation at low temperature through their RNA unwinding activity.