gebhart/patrepeval huggingface dataset:
Effects of solvent, protonation, and N-alkylation on the nitrogen-15 chemical shifts of pyridine and related compounds (1978)

The ^(15)N chemical shift of pyridine has been measured in he gas phase and in a variety of solvents. The solvent-induced resonances are all upfield of the gas phase and correlate qualitatively with hydrogen-bonding capacity. The finding of a reasonable linear correlation with the Kosower 2 values indicates that the solvent shifts are dominated by the contribution of the n→^*π^* transition to the secondary paramagnetic shift term. No correlation was found with either the solvent dielectric constant, є, or the function (є - 1)/(2є + 2.5). Large solvent effects were found for the ^(15)N resonances of pyridine hydrochlorides,\nand these require that interpretation of protonation shifts be made with care. In contrast to protonation shifts, methylation shifts are essentially solvent and counterion independent. The changes in ^(15)N chemical shifts of 4-substituted pyridines, on changing the solvent from benzene to methanol, correlate with the basicity of the solute, which also indicates the importance of hydrogen bonding in determining the solvent dependences of pyridine-nitrogen shifts.
[Induction of transposon Tn1 translocation in UV-irradiated Escherichia coli cells]. (1981)

Ampicillin transposon Tn1 translocates from plasmid RP4 into E. coli chromosome with a frequency of about 3.10(-4) per cell. Irradiation of bacteria with UV-light increases the frequency of translocation essentially. Mutation in lexA gene controlling the expression of cell UV-inducible functions blocks the induction of transposon translocation. Protein synthesis inhibitor--chloramphenicol and transcription inhibitor--rifampicin decrease the effect of UV-light on transposition process. A possible mechanism of inducible transposition is discussed.
Crystal Orientation and Magnetic Properties in Thin-Gauge Silicon-Iron Sheets (1987)

The dependence of magnetic properties on sheet thickness of polycrystal thin-gauge silicon-iron sheets was studied under application of tensile stress. It was confirmed that iron loss decreases as crystal orientation improves at low thicknesses. Application of high tensile stress in the thin-gauge range does have an effect in reducing hysteresis loss.
Energy saving with multi-connections over IEEE 802.16e networks (2011)

This paper considers the energy saving problem of IEEE 802.16e networks which consist of a base station and multiple mobile stations. The mobile station may establish one or multiple connections that have specific QoS requirements, including a bandwidth requirement and delay bounds. Since the mobile station turns off the transceiver to save energy when all connections of the mobile station enter sleep mode. Hence, for minimizing the energy consumption of the mobile station has to schedule each connection efficiently according to the QoS requirements and its sleep cycle. The proposed problem is formulated as an ILP problem that minimize the total number of active frames to save energy. A heuristic algorithms, bandwidth reservation scheme (BRS), is also proposed to improve the computing efficiency. Our approaches not only guarantee the QoS for real-time connections, but also minimize power consumption of mobile stations. Simulation results demonstrate that BRS outperform the previous approaches in terms of energy saving and bandwidth utilization.
Storage Variability among Short-day Onion Cultivars under High Temperature and High Relative Humidity, and its Relationship with Disease Incidence and Bulb Characteristics (2002)

In the tropics, onion ( Allium cepa L.) bulbs are usually stored in shelters under ambient conditions resulting in severe storage losses. This study was aimed at determining whether variation in bulb storability exists among short-day onion cultivars and whether the trait can be improved through conventional breeding. Twelve onion cultivars with different degrees of storability were selected from preliminary experiments. Bulbs of selected cultivars were grown and stored for 3 months under ambient conditions. Observations were made on disease incidence at harvest, percentage diseased bulbs, and storage disease incidence of bacterial soft rot [BR ( Pseudomonas gladioli pv. alliicola Burkholder)], black mold [BM ( Aspergillus niger Tiegh.)], and fusarium basal rot ( Fusarium oxysporum Schlechtend.:Fr. f. sp. cepae ) after 3 months of storage. Data on bulb characteristics such as bulb fresh weight (FW), dry matter (DM) content, total soluble solids (TSS), and pyruvic acid content were recorded at harvest. Mean storage losses of cultivars ranged from 21% to 99% over 3 years. Diseases were the major causes of storage losses, with BR and BM being the most predominant. Performance of most traits (including storage losses) was significantly influenced by year (Y), cultivar (G), and Y × G interaction. Heavy rainfall during bulb development in 1997 may have contributed to higher disease incidence at harvest, higher percentage of diseased bulbs during storage, and lower DM, and TSS of the cultivars. Cultivars with good storability, such as `Red Pinoy' and `Serrana', were less sensitive to stressful environments and high disease pressure. Incidence of storage diseases was significantly correlated with DM ( r = -0.65 to -0.84) and TSS ( r = -0.66 to -0.87), as well as incidence of BR ( r = 0.57 to 0.94) in each year. Thus, they could be good indicators for evaluating storability. Cultivars with good storability tended to have small bulbs, as average bulb FW was positively correlated with incidence of storage diseases. Disease incidences on `Red Pinoy' and `Serrana', both in the field and in storage, were significantly lower than in the other cultivars, indicating they are tolerant to major storage diseases and that they could be used as donor parents for genetic improvement of onion storability.
Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence. (1987)

The presence of abundant intraneuronal amyloid in the form of neurofibrillary tangles (NFT) in the brains of Guamanian parkinsonism-dementia patients and the absence of extraneuronal amyloid in the form of vascular amyloid deposits or senile plaques permit the purification of NFT without contamination with extraneuronal amyloid. Thus, we have isolated and determined the amino acid sequence of the polypeptide subunit of the amyloid fibrils of these NFT and describe their ultrastructure. The NFT, which consist of single and paired helical filaments, similar to those of Alzheimer disease, and occasionally triple helical filaments, are composed of multimeric aggregates of a polypeptide of 42 amino acids (A4 protein). The relative molecular mass of the subunit protein, 4.0-4.5 kDa, is the same as the molecular mass of the amyloid of NFT, of the amyloid plaque cores, and of vascular amyloid deposits in Alzheimer disease and Down syndrome; the sequence of 15 amino acid residues at the N-terminus of the amyloid fibrils in the NFT of Guamanian parkinsonism-dementia is identical to that of the amyloid of NFT, amyloid plaque cores, and cerebrovascular deposits in Alzheimer disease and Down syndrome. Furthermore, the heterogeneity, or variation in polypeptide length, of the N-terminus of the amyloid of Guamanian parkinsonism-dementia is the same as in Alzheimer disease and Down syndrome. Our observations indicate that the brain amyloids of these diseases have a common subunit protein, which would also indicate a common pathogenesis.
Trastuzumab-induced cardiotoxicity in early breast cancer patients: a retrospective study of possible risk and protective factors (2013)

TIC is a frequent, albeit generally mild, adverse event in clinical practice. Further studies are warranted to better define the risk of and protective factors for TIC.
A Novel Method of Landmines Detection Based on Improved SVM (2006)

To detect landmines in real SAR images, detection process based on PCA and SVM techniques is proposed in this paper. Firstly, a referential deflection-optimal linear-quadratic(DOLQ) detector is presented. Then, the proposed centering PCA+SVM method is developed and compared with the above benchmark. A morphological processing procedure is used to remove the isolated spurious pixels and to form landmine objects in the binary images. Finally, the experimental results show that the novel method can constantly outperform the DOLQ detector in terms of POD(probility of detection) and the SVM method in terms of training and classification times in landmine detection.
[The health situation of the non-institutionalized elderly urban population of Castro Uridiales and the differentiating characteristics of those attending the health center frequently]. (1998)

The results coincided with other studies in most of the items analysed. It is important to be aware of the worse functional and cognitive condition of the group which attended the Health Centre least. Sub-groups of the elderly still need to be studied.
Large‐scale stratigraphic architecture, eustatic variation, and unsteady tectonism: A theoretical evaluation (1991)

We incorporate a process‐based depositional model with basin subsidence models to predict stratigraphic records. This allows us to investigate the importance of subsidence geometry on coastal stratigraphy and thus to characterize and compare the stratigraphic architecture of two categories of tectonic basins. The models demonstrate that the correlation of stratigraphic sequences to eustatic cycles is not the same in passive margin basins as in foreland basins and that in a foreland basin, the record of episodic tectonism is distinct from that of eustatic sea level change. In the model, sediment transport is approximated by slope‐controlled diffusion; nonmarine transport is treated as more efficient diffusion than marine transport. Three different subsidence and sediment supply models are examined: a simple passive margin basin, a simple foreland basin, and then a foreland basin for which vertical motions are driven by thrust shortening that is compensated flexurally and for which sediment supply is related to relief. Predicted passive margin stratigraphies, for cases of varying eustatic sea level, are similar to those of natural basins and include progradational packages and subaerial unconformities, which are used to define sequence boundaries that form during sea level fall. We explore the timing relationships between stratigraphic features and a sinusoidal sea level history, showing that the phase relationship depends on subsidence, sediment flux, efficiency of sediment transport, and period and amplitude of sea level. When the basic geometry of the basin is inverted, placing the sediment supply on the side with maximum subsidence as is the case in foreland basins, the sequence character changes markedly: subaerial erosion does not generate unconformities. In the models of a dynamic foreland basin, sediment supply and subsidence are linked to the structure of the flanking thrust belt and are not necessarily constant. For steady thrusting and variable sea level, unconformities that define sequence boundaries form only on the distal or forebulge side of the basin, and the ages of the sequence boundaries correlate to limes of rising sea level. In cases of constant sea level but variable thrusting, subaerial unconformities are cut locally on both the proximal margin of the basin and the distal margin of the basin, yet the ages of the proximal margin and distal margin unconformities are out of phase in the tectonic cycle: erosion is most pronounced during quiescence on the proximal side and during thrusting on the distal side.
PEG‐Grafted Chitosan as an Injectable Thermoreversible Hydrogel (2005)

PEG-grafted chitosan was formulated such that its solution undergoes a thermally reversed phase transition from an injectable free-flowing solution at low temperature to a gel at body temperature. Aqueous solutions of PEG-grafted chitosan can be prepared at physiological pH values, thereby allowing safe incorporation of bioactive molecules. This injectable thermoreversible hydrogel is potentially suitable for a wide range of biomedical applications, particularly in sustained in vivo drug release and tissue engineering. An aqueous solution of PEG-grafted chitosan polymer is injectable at low temperatures but forms a gel at body temperature.
Effects of enucleation of the fixating eye on strabismic amblyopia in monkeys. (1986)

The effects of enucleation of the fixating eye on the visual function of the deviating eye were studied in two rhesus monkeys with strabismic amblyopia. An esotropia was surgically induced when the monkeys were approximately 1 mo of age, and the fixating eyes were then enucleated at age 3 yr 11 mo. Four measures of visual function (photopic increment-threshold spectral sensitivity, scotopic spectral sensitivity, spatial modulation sensitivity, and temporal modulation sensitivity) were determined for both eyes prior to enucleation and for the deviating eyes over an 11-month period following the surgical removal of the fixating eye. Both monkeys showed some recovery of contrast sensitivity of their deviating eyes. The extrapolated cut-off values for their spatial modulation sensitivity functions increased from .27 to 2.8 c/deg for one animal and from .28 to 6.3 c/deg for the other. The extrapolated cut-off frequencies for the temporal modulation sensitivity functions of both animals showed an increase of 20-25 Hz compared to the pre-enucleation values. The spectral sensitivity functions of one monkey recovered to near normal values following enucleation, while both the photopic and scotopic functions of the other animal remained at pre-enucleation levels. Overall, the results of the experiments indicate that the removal of the fixating eyes of monkeys with strabismic amblyopia can result in significant improvements in the functional capacity of their deviating eyes.
Clinical presentation, hospital length of stay, and readmission rate in patients with heart failure with preserved and decreased left ventricular systolic function (2002)

The clinical presentation, hospital length of stay, and readmission rate for congestive heart failure are similar in patients with preserved and decreased LV systolic function.
Computational design of actuated deformable characters (2013)

We present a method for fabrication-oriented design of actuated deformable characters that allows a user to automatically create physical replicas of digitally designed characters using rapid manufacturing technologies. Given a deformable character and a set of target poses as input, our method computes a small set of actuators along with their locations on the surface and optimizes the internal material distribution such that the resulting character exhibits the desired deformation behavior. We approach this problem with a dedicated algorithm that combines finite-element analysis, sparse regularization, and constrained optimization. We validate our pipeline on a set of two- and three-dimensional example characters and present results in simulation and physically-fabricated prototypes.
Crosstalk and switching characteristics in directional couplers (1988)

The normal mode approach is used to calculate the fundamental limits on crosstalk and switching characteristics in directional coupler switches of the stepped delta beta type. The normal modes are calculated numerically as well as analytically using a method for computing the eigenmodes of two coupled, identical waveguides with an antisymmetric index perturbation. The results of the two methods are compared to one another as well as to the results of coupled-mode theory. It is shown that the theoretical minimum for the crosstalk level is very low for the stepped delta beta structure. Nonzero crosstalk was found in some cases where coupled-mode theory predicts zero crosstalk. This is attributed to the improper handling of discontinuities in coupled-mode theory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
In Vitro Synergistic Effects of Double and Triple Combinations of β-Lactams, Vancomycin, and Netilmicin against Methicillin-Resistant <i>Staphylococcus aureus</i> Strains (2000)

Several studies have previously reported synergistic effects between vancomycin and a given beta-lactam or a given aminoglycoside against methicillin-resistant Staphylococcus aureus (MRSA) strains. The aim of our study was to exhaustively compare the effects of different combinations of a beta-lactam, vancomycin, and/or an aminoglycoside against 32 clinical MRSA strains with different aminoglycoside susceptibility patterns. The effects of 26 different beta-lactam-vancomycin and 8 different aminoglycoside-vancomycin combinations were first studied using a disk diffusion screening method. The best interactions with vancomycin were observed with either imipenem, cefazolin, or netilmicin. By checkerboard studies, imipenem-vancomycin and cefazolin-vancomycin each provided a synergistic bacteriostatic effect against 22 strains; the mean fractional inhibitory concentration (FIC) indexes were 0.35 and 0.46 for imipenem-vancomycin and cefazolin-vancomycin, respectively. The vancomycin-netilmicin combination provided an indifferent effect against all of the 32 strains tested; the mean of FIC index was 1. 096. The mean concentrations of imipenem, cefazolin, netilmicin, and vancomycin at which FIC indexes were calculated were clinically achievable. Killing experiments were then performed using imipenem, cefazolin, netilmicin, and vancomycin at one-half of the MIC, alone and in different combinations, against 10 strains. The vancomycin-netilmicin regimen was rarely bactericidal, even against strains susceptible to netilmicin. The imipenem-vancomycin and cefazolin-vancomycin combinations were strongly bactericidal against six and five strains, respectively. The addition of netilmicin markedly enhanced the killing activity of the combination of cefazolin or imipenem plus vancomycin, but only for the MRSA strains against which the beta-lactam-vancomycin combinations had no bactericidal effect. It is noteworthy that the latter strains were both susceptible to netilmicin and heterogeneously resistant to methicillin.
X-ray fluorescence microtomography- and polycapillary-based confocal imaging using synchrotron radiation (2004)

This work illustrates the development of X-ray fluorescence tomography and polycapillary based confocal imaging towards a three-dimensional (3D), quantitative analytical method with lateral resolution levels down to the 2-20 μm scale. Detailed analytical characterization is given for polycapillary based confocal XRF imaging, which is a new variant of the 3D micro-XRF technique. Applications for 2D/3D micro-XRF are illustrated for the analysis of biological (zooplankton) and geological samples (microscopic inclusions in natural diamonds and fluid inclusions in quartz). Based on confocal imaging, fully three-dimensional distributions of trace elements could be obtained, representing a significant generalization of the regular 2D scanning technique for micro-XRF spectroscopy. The experimental work described in this paper has been carried out at the ESRF ID18F microfluorescence end-station and at HASYLAB Beam Line L.
2-V 900-MHz quadrature coupled LC oscillators with improved amplitude and phase matchings (2003)

Coupled LC oscillators are known to provide good performance in terms of phase noise, signal amplitude, power consumption, and quadrature output signals. However, IQ amplitude and phase mismatches in these oscillators can be quite large due to the serious mismatch problem of large area inductors and varactors. A simple design modification of the coupled LC oscillators shows a significant improvement of the amplitude and phase mismatches. Detailed operational principle is examined. A 2 V 900 MHz prototype using this simple idea has been designed.
(S)-Form of .ALPHA.-Methyl-N(.ALPHA.)-phthalimidoglutarimide, but Not Its (R)-Form, Enhanced Phorbol Ester-Induced Tumor Necrosis Factor-.ALPHA. Production by Human Leukemia Cell HL-60: Implication of Optical Resolution of Thalidomidal Effects. (1994)

The rate of racemization of N(alpha)-phthalimidoglutarimide (thalidomide) was determined as its half life to be 566 min at pH 7.4/37 degrees C. This fast racemization of thalidomide resulted in no apparent difference between (S)- and (R)-forms of the compound on enhancing activity of phorbol ester-induced tumor necrosis factor (TNF)-alpha production by human leukemia HL-60 cells. Optically pure forms of structurally related analog of thalidomide, (S)- and (R)-alpha-methyl-N(alpha)-phthalimidoglutarimides (methylthalidomides), which do not racemize under the physiological condition, were prepared. Only (S)-form of methylthalidomide, but not its (R)-form, elicited TNF-alpha production-enhancing effect, suggesting that the (S)-isomer of thalidomide would be the active form in terms of thalidomidal biological response modifying effects.
Orientation development in thermotropic liquid crystal polymers (1983)

Abstract Thermotropic liquid crystal polymers are a new class of polymeric materials that consist of rigid backbone molecules and thus, even in the quiescent condition, take extended chain conformation to form optically anisotropic melts. A systematic investigation was carried out on how this type of material responds to two basic flow fields: shear and elongation. Rheological properties of the polymer in these flow fields have also been measured. It was found that a high level of molecular orientation was readily obtained by elongational flow but not with shear flow. Specifically, extraordinarily high orientation was obtained when the melt was subjected to small elongational strains, whiel shear strain or shear rate had little effect. A possible mechanism to explain these behaviors is illustrated based on the existing observations or theories of rodlike molecules. This finding was used to interpret the orientation distribution in the extruded and injection‐molded articles.
Molecular organization and tissue-specific expression of an Arabidopsis 14-3-3 gene. (1996)

The 14-3-3 proteins, originally described as mammalian brain proteins, are ubiquitous in eukaryotes. We isolated an Arabidopsis 14-3-3 gene, designated GRF1-GF14 chi (for general regulatory factor1-G-box factor 14-3-3 homolog isoform chi), and characterized its expression within plant tissues. Sequence comparison of the GRF1-GF14 chi genomic clone with other 14-3-3 proteins demonstrated that the extreme conservation of 14-3-3 residues in several domains is encoded by the first three exons. The highly variable C-terminal domain is encoded by a divergent fourth exon that is unique among 14-3-3 homologs, suggesting that exon shuffling might confer gene-specific functions among the isoforms. The anatomical distribution and developmental expression of the Arabidopsis 14-3-3 protein were examined in transgenic plants carrying a GRF1-GF14 chi promoter-beta-glucuronidase construct. GF14 chi promoter activity was observed in the roots of both seedlings and mature plants. In immature flowers, GF14 chi promoter activity was localized to the buds. However, as the flowers matured, GF14 chi promoter activity was restricted to the stigma, anthers, and pollen. In immature siliques, GF14 chi promoter activity was initially localized to styles and abscission zones but was subsequently observed throughout mature siliques. In situ hybridization demonstrated that GF14 chi mRNA expression was prominent in epidermal tissue of roots, petals, and sepals of flower buds, papillae cells of flowers, siliques, and endosperm of immature seeds. Thus, plant 14-3-3 gene expression exhibits cell- and tissue-specific localization rivaling that observed for 14-3-3 proteins within the mammalian brain.