gebhart/patrepeval huggingface dataset:
The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. (1989)

VLA-2 (also called gpIa/IIa on platelets) is a collagen receptor with a unique alpha subunit and a beta subunit common to other adhesion receptors in the VLA/integrin family. Multiple cDNA clones for the human VLA-2 alpha 2 subunit have been selected from a lambda gtll library by specific antibody screening. The 5,374-bp nucleotide sequence encoded for 1,181 amino acids, including a signal peptide of 29 amino acids followed by a long extracellular domain (1,103 amino acids), a transmembrane domain, and a short cytoplasmic segment (22 amino acids). Direct sequencing of purified alpha 2 protein confirmed the identity of the 15 NH2-terminal amino acids. Overall, the alpha 2 amino acid sequence was 18-25% similar to the sequences known for other integrin alpha subunits. In particular, the alpha 2 sequence matched other integrin alpha chains in (a) the positions of 17 of its 20 cysteine residues; (b) the presence of three metal-binding domains of the general structure DXDXDGXXD; and (c) the transmembrane domain sequence. In addition, the alpha 2 sequence has a 191-amino acid insert (called the I-domain), previously found only in leukocyte integrins of the beta 2 integrin family. The alpha 2 I-domain was 23-41% similar to domains in cartilage matrix protein and von Willebrand factor, which are perhaps associated with collagen binding. The NH2-terminal sequence reported here for alpha 2 does not match the previously reported alpha 2 NH2-terminal sequence (Takada, Y., J. L. Strominger, and M. E. Hemler. 1987. Proc. Natl. Acad. Sci. USA. 84:3239-3243). Resolution of this discrepancy suggests that there may be another VLA heterodimer that resembles VLA-2 in size but has a different amino acid sequence.
Investigation the Possibility of Using Peptides with a Helical Repeating Pattern of Hydro-Phobic and Hydrophilic Residues to Inhibit IL-10 (2016)

Blockade of IL-10 signalling clears chronic viral and bacterial infections. Immunization together with blockade of IL-10 signalling or relatively low level of IL-10 further enhances viral and bacterial clearance. IL-10 functions through binding to interleukin 10 receptor (IL-10R). Here we showed that peptides P1 and P2 with the hydrophobic and hydrophilic pattern of the IL10R-binding helix in IL-10 could bind with either IL-10R1 or IL-10, and inhibit inflammatory signals with long duration and negligible cytotoxicity in vitro. Furthermore, P2 can enhance antigen specific CD8+ T cell responses in mice induced by the vaccine based on a long peptide of protein E7 in a human papillomavirus type 16.
CHARACTERIZING ELASTIC AND VISCOELASTIC PROPERTIES OF YOUNG AND AGED MOUSE OOCYTES USING A PDMS MICRODEVICE (2011)

This paper presents the characterization of elastic and viscoelastic properties of young and aged mouse oocytes using a polydimethylsiloxane (PDMS) microdevice that we previously reported. Nanonewton-level forces applied to the oocytes are measured by visually tracking the deformation of low-stiffness PDMS supporting posts. In this work, stress-relaxation test of the oocytes is performed using the microdevice, and a two-step, large-deformation mechanical model is developed to extract the mechanical properties of the oocytes from the measured force-deformation data. It was found that the aged oocytes are significantly softer (elastic modulus: 2.2 kPa vs. 5.2 kPa in young oocytes) but more viscous (relaxation time: 4.1 s vs. 2.3 s in young oocytes).
Restoring warped document images through 3D shape modeling (2006)

Scanning a document page from a thick bound volume often results in two kinds of distortions in the scanned image, i.e., shade along the "spine" of the book and warping in the shade area. In this paper, we propose an efficient restoration method based on the discovery of the 3D shape of a book surface from the shading information in a scanned document image. From a technical point of view, this shape from shading (SFS) problem in real-world environments is characterized by 1) a proximal and moving light source, 2) Lambertian reflection, 3) nonuniform albedo distribution, and 4) document skew. Taking all these factors into account, we first build practical models (consisting of a 3D geometric model and a 3D optical model) for the practical scanning conditions to reconstruct the 3D shape of the book surface. We next restore the scanned document image using this shape based on deshading and dewarping models. Finally, we evaluate the restoration results by comparing our estimated surface shape with the real shape as well as the OCR performance on original and restored document images. The results show that the geometric and photometric distortions are mostly removed and the OCR results are improved markedly.
Recent advances in the development of histamine H<sub>3</sub>antagonists (2007)

The histamine H(3) receptor is involved in the central and peripheral regulation of levels of histamine and other neurotransmitters (e.g., acetylcholine, noradrenaline, dopamine, serotonin and GABA), which sets it up as a target in the treatment of various CNS (e.g., depression, schizophrenia, ADHD, dementia, neuropathic pain and sleep disorders), metabolic syndrome (e.g., obesity) and allergic disorders. Novel chemical series from the most recent 2 years of patent literature have been reviewed. While overall structural diversity is moderate, these represent or relate to some of the compounds progressing through clinical trials (e.g., GSK-189254). However, an H(3) receptor drug still has yet to reach the market. Patenting activity is likely to remain high in the near future, bolstered by the commercial promise of potential H(3) receptor drugs.
Arachidonoyl ethanolamide (AEA)‐induced apoptosis is mediated by J‐series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade (2011)

The endocannabinoid arachidonoyl ethanolamide (AEA) is a potent inducer of tumor cell apoptosis however its mechanism of cytotoxicity is unclear. A previous report from our laboratory showed that AEA induced cell death in a cyclooxygenase-2 (COX-2)-dependent manner and in this report our data indicate that AEA-induced apoptosis is mediated by COX-2 metabolic products of the J-series. In experiments conducted with JWF2 keratinocytes which over-express COX-2, AEA caused a concentration-regulated increase in J-series prostaglandin production and apoptosis. Similarly, cell treatment with exogenously added J-series prostaglandins (15-deoxy, Δ(12,14) PGJ(2) and PGJ(2)) induced apoptosis. AEA-induced apoptosis was inhibited by the antioxidant, N-acetyl cysteine, indicating that reactive oxygen species generation was required for apoptosis. Using antagonists of cannabinoid receptor 1, cannabinoid receptor 2, or transient receptor potential cation channel, subfamily V, member 1, it was observed that cannabinoid receptor inhibition did not block AEA-mediated cell death. In contrast, an inhibitor of fatty acid amide hydrolase (FAAH) potentiated AEA-induced J-series PG synthesis and apoptosis. These results suggest that the metabolism of AEA to J-series PGs regulates the induction of apoptosis in cells with elevated COX-2 levels. Our data further indicate that the proapoptotic activity of AEA can be enhanced by combining it with an inhibitor of FAAH. As such, AEA may be an effective agent to eliminate tumor cells that over-express COX-2.
<title>Comparison of endmember extraction techniques</title> (2002)

Image pixels represent either distinct materials (end members) that are present in the image, or mistures of two or more of these pure materials. Estimates of pure end member spectra are needed for spectral libraries and for input into pixel unmixing codes. We investigate three algorithms for estimating end member spectra: (1) the convex hull method in which an n-dimensional surface is shrink- wrapped around the data cloud; (2) a pixel-by-pixel search method in which pixels that have sufficiently different spectral angles are declared end members; (3) a pixel-by- pixel search method using Euclidean distance as a measure, followed by clustering to improve the estimate of the spectra. The convex hull technique should provide an estimate of pure end member spectra while the pixel-by-pixel search methods should find both distinct end members and distinct mixtures. Each method requires user-set thresholds to find distinct spectra, which can be expressed in spectral angle degrees or image-dependent units for Euclidean distance. Estimates for the lower threshold (below which two spectra are considered to be the same material) and the upper threshold (above which two spectra are definitely different materials) are derived empirically. Low-altitude AVIRIS data will be used to demonstrate the utility of these end member extraction methods. We will illusxtrate how well each technique compare to the other, and compare how well individual algorithms work across adjacent scenes.
Study on Isothermic Sampling from the Deep Sea (Part 1). Thermal Insulation Characteristics of Composite Materials Effective under High Hydrostatic Pressure. (1994)

It was tested whether several kinds of neoprene and syntactic foam materials currently available could be effective as thermal insulators used in the deep-sea up to 6500 m depth. The density and thermal conductivity of the materials after pressurized repeatedly with various pressure, and the bulk modulus of them were measured under atmospheric pressure, The experimental data obtained thus derived the heat flow through the materials under high hydrostatic pressure. Based on the data, the tested materials were evaluated on the ability as deep-sea thermal insulators, to suggest that the syntactic foam is more excellent than the neoprene foam in pressure-as well as in thermal-proof and, though, the latter might be also effective for thermal-proof since it can almost recover the original volume when it is floated up to the shallow water.
Taxane sensitivity of ovarian carcinoma in vitro. (1997)

Paclitaxel, the first clinically available taxane, has proven to be effective in the treatment of ovarian carcinoma. Docetaxel is the second taxoid derivative which has also shown activity in ovarian carcinoma. These two compounds have clear differences in pharmacokinetics and side-effects. In the present study we have tested the cytotoxic effect of docetaxel in seven ovarian carcinoma cell lines using the 96-well plate clonogenic assay. These results have been compared with data obtained from our recent study on cisplatin and paclitaxel sensitivities of the same cell lines. Chemosensitivity has been expressed as IC50 value, the drug concentration causing 50% inhibition of clonogenic survival. The IC50 values for docetaxel were 0.23-2.30 nM showing a 10-fold difference between individual cell lines. On a molar basis, docetaxel was 1.2 to 2.6 times more active than paclitaxel in six out of seven cell lines. This may be explained by differences in the mechanism of action or by differences in other pharmacological properties.
Low resistance Ti∕Al∕Ti–W∕Au Ohmic contact to n-GaN for high temperature applications (2007)

Metallization schemes consisting of titanium/aluminum/titanium-tungsten/gold (Ti∕Al∕Ti–W∕Au) were developed to Ohmic contact formation to n-GaN. The effect of Ti–W as a diffusion barrier layer on electrical and microstructural contact behaviors was evaluated. Regarding the electrical properties, excellent Ohmic contact resistances were obtained at the relatively low annealing temperature of 750°C, showing values as low as 0.29±0.01Ωmm. Intermetallic reactions formed during Ohmic contact annealing were investigated by energy dispersion spectroscopy. “Donutlike” features appeared on the surface showing a dependence of the size/density with the Ti–W layer thickness and the alloying conditions.
Actuation principle and property of magnetically controlled shape memory alloy actuators (2005)

This paper introduces the operation principle of magnetically controlled shape memory alloy (MSMA) actuators based on the shape variation of the NiMnGa alloys under external magnetic field. The experimental results show that the relationship between strain of MSMA and magnetic field is a nonlinear characteristic with saturate nature. Under the condition of constant temperature and magnetic field, the strain of the MSMA reduces linearly with respect to the pre-pressure increment. The magnetic control property of MSMA is sensitive to the temperature variation, and can be held only in the martensite phase. The tested dynamic magnetically conductive characteristics of MSMA show that the magnetic permeability of the MSMA is not constant, and reduces with respect to the increment of magnetic field. The relative saturate magnetic permeability of MSMA is about 1.5. Therefore, the MSMA is almost a non-magnetically conductive material.
Ecopedagogia del decreixement (2008)

El desenvolupament sostenible es un concepte «tou» i perillos, perjudicial segons Georgescu-Roetgen. Si proposem una ecopedagogia es perque pensadors com aquest romanes han elaborat teories d'ecoeconomia. El model economic (neoliberal o neomarxista) eliminava el concepte natura per incomode i, tanmateix, la natura no es inesgotable. No hi ha creixement infinit possible en un planeta finit. S'exploten els recursos naturals sense tenir en compte la petjada ecologica ni el temps necessari per a la seva renovacio.
Hierarchical Nanostructured 3D Flowerlike BiOCl<sub><i>x</i></sub>Br<sub>1–<i>x</i></sub> Semiconductors with Exceptional Visible Light Photocatalytic Activity (2013)

With careful rational optimization and substantial simplification of the syntheses of the recently reported alloys BiO(ClxBr1–x), we fabricated, via a very simple procedure and at room temperature, a unique visible-light-driven photocatalyst with excellent activity. The alloy BiOCl0.875Br0.125 totally decomposed 15 mg/L aqueous Rhodamine B solution within 120 s upon irradiation with visible light (λ > 422 nm). The transparent substrate acetophenone was also swiftly destroyed under the above conditions. The catalyst maintained partial activity even after switching off the light source. Initial mechanistic studies clearly suggest that the mode of action of these materials is fundamentally different from previously reported photocatalytic mechanisms. Evidently, the putative molecular mechanism does not engage dye photosensitization or oxygen radicals.
A selective and efficient method for alcohol oxidations mediated by N-oxoammonium salts in combination with sodium bromite (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA selective and efficient method for alcohol oxidations mediated by N-oxoammonium salts in combination with sodium bromiteTsutomu Inokuchi, Sigeaki Matsumoto, Tokio Nishiyama, and Sigeru ToriiCite this: J. Org. Chem. 1990, 55, 2, 462–466Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/jo00289a016https://doi.org/10.1021/jo00289a016research-articleACS PublicationsRequest reuse permissionsArticle Views2366Altmetric-Citations129LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma (2008)

This study provides first clinical evidence for the implication of a "glioma stem cell" or "self-renewal" phenotype in treatment resistance of glioblastoma. Biologic mechanisms identified here to be relevant for resistance will guide future targeted therapies and respective marker development for individualized treatment and patient selection.
Organometallic molecular precursors for low‐temperature MOCVD of III–V semiconductors (1991)

Abstract Metal‐organic chemical vapor deposition (MOCVD) is a suitable technique for the preparation of III–V epitaxial layers which are used in the fabrication of microelectronic and optoelectronic devices. The usual Ga and As sources for GaAs are Ga(CH 3 ) 3 and AsH 3 , respectively. However, the use of these precursors has some disadvantages including: The toxicity and storage of arsine, stoichiometry control, carbon incorporation and unwanted side reactions. Several groups of researchers have investigated alternative sources for both the group–III and group‐V elements. A review of these new organometallic precursors is presented in this paper. However, because group‐III and group‐V elements form Lewis‐acid/base adducts in the MOCVD reactor, we have especially investigated the use of this class of compounds as single starting molecules. Several adducts have been successfully used for the epitaxial growth of GaAs. Moreover, to avoid any stoichiometry loss due to dissociation of the adduct, the properties of organometallic molecules which feature a covalent bond between the group‐III and group‐V elements have also been investigated. These covalent compounds are probably formed in the MOCVD reactor when alkyl group‐V compounds containing acidic hydrogen R 3− n MH n (M = As, P; n = 1,2) are used. Such new precursors are also briefly reviewed.
Minimum Critical Dimensions for Water Solutions (1961)

By use of the Los Alamos transport code, a parametric set of criticality conditions for one-dimensional geometries of light water solutions of the fissionable materials U233, U235, and Pu239 has been determined. Minimum critical dimensions for slabs and cylinders and critical radius, mass, and volume for spheres as a function of solution concentrations (kg/1) and H/X atomic ratio are shown for bare and light water reflected solutions. Results of experimental studies for critical dimensions are given to support the study.
3D interconnection and packaging: impending reality or still a dream? (2004)

Traditional interconnect schemes are basically two-dimensional. It has long been a dream for system designers to be able to combine multiple integrated circuits by connecting them in the third dimension. Three approaches to the 3D interconnect problem are described: system in a package (3D-SiP), system on a chip (3D-SoC) and 3D integrated circuits (3D-IC).
Structure of azotobactin D, a siderophore of Azotobacter vinelandii strain D (CCM 289) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of azotobactin D, a siderophore of Azotobacter vinelandii strain D (CCM 289)Pascal Demange, Andrew Bateman, Anne Dell, and Mohamed A. AbdallahCite this: Biochemistry 1988, 27, 8, 2745–2752Publication Date (Print):April 19, 1988Publication History Published online1 May 2002Published inissue 19 April 1988https://pubs.acs.org/doi/10.1021/bi00408a014https://doi.org/10.1021/bi00408a014research-articleACS PublicationsRequest reuse permissionsArticle Views405Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neglected anterior shoulder dislocation: open remplissage of the Hill-Sachs lesion with the infraspinatus tendon. (2010)

Neglected anterior shoulder dislocation is a rare condition; reduction usually requires an open procedure. There is usually a concurrent Hill-Sachs lesion, with the humeral head impaled over the anterior rim of the glenoid. Large, engaging Hill-Sachs lesions can contribute to continued shoulder instability, and therefore require a specific action. Reconstruction of the humeral head with an osteochondral allograft has been advocated, but allografts are not easily available in some countries, such as Egypt. For this reason, I switched to the open infraspinatus remplissage technique. I report the results with this technique, in four young adult patients who presented with a locked anterior shoulder dislocation, which had been left unreduced for 10 to 20 weeks. The infraspinatus tendon was pulled into the humeral defect with a four limbs suture anchor; as a result, the lesion became extra-articular. A Putti-Platt procedure was added to obtain anterior stability, except in one patient with a concurrent glenoid defect which required a Latarjet procedure. The mean follow-up period was 32 months, without recurrence or other complications. The mean postoperative Constant score was 74, and the range of motion was satisfactory, with a functional range of external rotation.
Ultrasensitive 1D field-effect phototransistors: CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> nanowire sensitized individual carbon nanotubes (2016)

Field-effect phototransistors were fabricated based on individual carbon nanotubes (CNTs) sensitized by CH3NH3PbI3 nanowires (MAPbI3NWs). These devices represent light responsivities of R = 7.7 × 10(5) A W(-1) under low-lighting conditions in the nW mm(-2) range, unprecedented among CNT-based photodetectors. At high incident power (∼1 mW mm(-2)), light soaking results in a negative photocurrent, turning the device insulating. We interpret the phenomenon as a result of efficient free photoexcited charge generation and charge transfer of photoexcited holes from the perovskite to the carbon nanotube. The charge transfer improves conductance by increasing the number of carriers, but leaves electrons behind. At high illumination intensity their random electrostatic potential quenches mobility in the nanotube.
Insecticidal activity of the pyrimidine nucleoside analogue (<i>E</i>)‐5‐(2‐bromovinyl)‐2′‐deoxyuridine (BVDU) (2005)

The insecticidal activity of the antiherpetic agent (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) was assessed in in vivo assays against the fall armyworm, Spodoptera frugiperda (JE Smith) (Lepidoptera, Noctuidae). BVDU, mixed into an artificial diet, caused a variety of effects, depending on the concentration used. Compared with controls, food intake was lower, larval growth was retarded and larval development was prolonged. The treated larvae formed smaller pupae and the hatching moths often showed morphogenetic defects. A higher mortality could be found in larval and pupal stages and was generally caused by moult disruption. A choice assay showed that BVDU has very slight feeding-deterrent properties, which only partly explain the toxic effects. The agent most probably acts through its cytostatic activity that has been described previously using cell lines of different insect species.