gebhart/patrepeval huggingface dataset:
Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation (2001)

The use of myeloablative preparative therapy and allogeneic stem cell transplantation (alloSCT) as salvage therapy for adult patients with relapsed hematologic malignancy after autologous stem cell transplantation (autoSCT) is generally unsuccessful due to very high treatment-related mortality rates. We evaluated the outcome of HLA-matched related donor alloSCT following nonmyeloablative preparative therapy in 13 patients (median age, 38 years) with relapsed hematologic malignancies (Hodgkin's disease, n = 4; Hodgkin's disease and advanced myelodysplastic syndrome, n = 1; non-Hodgkin's lymphoma, n = 6; multiple myeloma, n = 2) after initial autoSCT. Median time from autoSCT to alloSCT was 12 months (range, 3-24 months); 6 patients had chemotherapy-refractory disease following autoSCT, 6 were in untreated relapse, and 1 had a partial response from salvage chemotherapy. Preparative therapy consisted of cyclophosphamide, 150-200 mg/kg; peritransplantation anti-thymocyte globulin; thymic irradiation (in patients who had not received previous mediastinal irradiation); and a very short course of cyclosporine as GVHD prophylaxis. All patients achieved initial mixed chimerism as defined by greater than 1% donor peripheral white blood cells. Seven patients, who had no evidence of GVHD, received prophylactic DLI beginning 5 to 6 weeks after transplantation for conversion of mixed chimerism to full donor hematopoiesis and to optimize a graft-versus-tumor effect. Six patients showed conversion to full donor chimerism and 1 lost the graft. Grade II or greater acute GVHD occurred in 9 patients. Seven patients achieved a complete response; 6 had no response. The median survival time of the 13 patients is currently 10 months (range, 3-39 months), with an overall survival probability at 2 years of 45% (95% confidence interval [CI], 19%-73%) and a disease-free survival probability at 2 years of 37.5% (95% CI, 12%-65%). Thus, this novel nonmyeloablative alloSCT strategy followed by prophylactic DLI was well tolerated and can result in durable disease-free survival among patients with advanced hematologic malignancies after a failed autoSCT. Further follow-up and evaluation of additional patients are required to conclusively establish the role of this strategy in the treatment of hematologic malignancies after an autologous transplantation.
A Discrete Fourier-Cosine Transform Chip (1986)

An 8-point Fourier-cosine transform chip designed for a data rate of 100 Mbits/s is described. The top-down design is presented step by step, including algorithm modification for VLSI suitability, architectural choices, testing overhead, internal precision assignments, mask generation, and finally, verification of the layout. A high-level language (C) design tool was developed concurrently with the layout. This tool allows mimicking exactly the different representations of the algorithm: software, mask, and chip. This provides an automatic cross-checking at all design stages. The VLSI environment created by this tool, as well as existing powerful CAD tools, made a fast design-time possible.
Effect of Zn<sup>2+</sup>, Fe<sup>3+</sup>and Cr<sup>3+</sup>addition to hydroxyapatite for its application as an active constituent of sunscreens (2010)

Biocompatible phosphate materials are used in different applications like bone and dental implants, drug delivery systems and others, but could also be applied in inorganic sunscreens. Using sunscreens is extremely necessary, because long time exposure to sun can cause skin cancer. In this work chemical precipitation method has been used to produce hydroxyapatite. Cr3+, Zn2+ and Fe3+ doped samples were characterized using powder X-Ray Diffraction (XRD) and Optical Absorption techniques. X-ray diffraction measurements confirmed the materials were in the expected crystalline structures. The crystallite size as measured from the X-ray pattern was 23–27 nm (±1). The absorption spectra in the ultraviolet and visible ranges indicate that appropriately doped and sized hydroxyapatite particles may have potential applications as active constituents of sunscreens.
Amyloid-β Annular Protofibrils Evade Fibrillar Fate in Alzheimer Disease Brain (2011)

Annular protofibrils (APFs) represent a new and distinct class of amyloid structures formed by disease-associated proteins. In vitro, these pore-like structures have been implicated in membrane permeabilization and ion homeostasis via pore formation. Still, evidence for their formation and relevance in vivo is lacking. Herein, we report that APFs are in a distinct pathway from fibril formation in vitro and in vivo. In human Alzheimer disease brain samples, amyloid-β APFs were associated with diffuse plaques, but not compact plaques; moreover, we show the formation of intracellular APFs. Our results together with previous studies suggest that the prevention of amyloid-β annular protofibril formation could be a relevant target for the prevention of amyloid-β toxicity in Alzheimer disease.
Treated Wastewater Effluent as a Source of Microbial Pollution of Surface Water Resources (2013)

Since 1990, more than 1.8 billion people have gained access to potable water and improved sanitation worldwide. Whilst this represents a vital step towards improving global health and well-being, accelerated population growth coupled with rapid urbanization has further strained existing water supplies. Whilst South Africa aims at spending 0.5% of its GDP on improving sanitation, additional factors such as hydrological variability and growing agricultural needs have further increased dependence on this finite resource. Increasing pressure on existing wastewater treatment plants has led to the discharge of inadequately treated effluent, reinforcing the need to improve and adopt more stringent methods for monitoring discharged effluent and surrounding water sources. This review provides an overview of the relative efficiencies of the different steps involved in wastewater treatment as well as the commonly detected microbial indicators with their associated health implications. In addition, it highlights the need to enforce more stringent measures to ensure compliance of treated effluent quality to the existing guidelines.
0.15 μm InGaAs/AlGaAs/GaAs HEMT production process for high performance and high yield V-band power MMICs (2002)

We present a unique high yield, high performance 0.15 /spl mu/m HEMT production process which supports fabrication of MMW power MMICs up to 70 GHz. This process has been transferred successfully from an R&D process to TRW's GaAs production line. This paper reports the on-wafer test results of more than 1300 V-band MMIC PA circuits measured over 24 wafers. The best 2-stage V-band power MMICs have demonstrated state-of-the-art performance with 9 dB power gain, 20% PAE and 330 mW output power. An excellent RF yield of 60% was achieved with an 8 dB power gain and 250 mW output power specification.
Systemic fungicides (1961)

Abstract The article describes some of the main types of compounds possessing systemic antifungal properties, and their possible modes of action are discussed. the requirements for a compound to be a successful systemic fungicide are listed, together with the probable lines of future development in this field of crop protection.
Si–CN Bond Cleavage of Silyl Cyanides by an Iron Catalyst. A New Route of Silyl Cyanide Formation (2013)

Abstract The reaction of silyl cyanide (R3SiCN) with hydrosilane (R′3SiH) in the presence of a catalytic amount of [(η5-C5H5)Fe(CO)2Me] formed R′3SiCN and R3SiH. This reaction involves Si–CN bond cleavage and provides a new method for the preparation of silyl cyanides. DFT calculation showed that coordinatively unsaturated [(η5-C5H5)Fe(CO)(SiMe3)] reacts exothermically with Me3SiCN to give the CN π-coordinated complex, [(η5-C5H5)Fe(CO)(η2-Me3SiCN)(SiMe3)], followed by exothermic silyl migration from the iron to the nitrogen atom of the η2-coordinated Me3SiCN with the activation energy of 8.8 kcal mol−1 to give [(η5-C5H5)Fe(CO)(Me3SiC=NSiMe3-κC,κN)]. The complex is one of the intermediates in the catalytic cycle. The related complex [(η5-C5Me5)Fe(CO)(κ-C,N-t-BuMe2SiC=NSiPh3)] was isolated in the reaction of [(η5-C5Me5)Fe(CO)(py)(SiPh3)] with t-BuMe2SiCN and characterized by 1H, 13C, and 29Si NMR spectroscopy. The activation energy of the Si–CN bond cleavage in [(η5-C5H5)Fe(CO)(κ-C,N-Me3SiC=NSiMe3)] was evaluated by DFT calculation to be 33.7 kcal mol−1 which is comparable to that in the reaction of acetonitrile (32.9 kcal mol−1).
Characterization of a parallel stranded DNA hairpin (1989)

Recently we have shown that synthetic DNA containing homooligomeric A-T base pairs can form a parallel-stranded intramolecular hairpin structure [van de Sande et al. (1988) Science (Washington, D.C.) 241, 551-557]. In the present study, we have employed NMR and optical spectroscopy to investigate the structure of the parallel-stranded (PS) DNA hairpin 3'-d(T)8C4(A)8-3' and the related antiparallel (APS) hairpin 5'-d(T)8C4(A)8-3'. The parallel orientation of the strands in the PS oligonucleotide is achieved by introducing a 5'-5' phosphodiester linkage in the hairpin loop. Ultraviolet spectroscopic and fluorescence data of drug binding are consistent with the formation of PS and APS structures, respectively, in these two hairpins. Vacuum circular dichroism measurements in combination with theoretical CD calculations indicate that the PS structure forms a right-handed helix. 31P NMR measurements indicate that the conformation of the phosphodiester backbone of the PS structure is not drastically different from that of the APS control. The presence of slowly exchanging imino protons at 14 ppm and the observation of nuclear Overhauser enhancement between imino protons and the AH-2 protons demonstrate that similar base pairing and base stacking between T and A residues occur in both hairpins. However, the small chemical shift dispersion observed in proton NMR spectra of the PS hairpin suggests that the stem of this hairpin is more regular than that of the APS hairpin. On the basis of NOESY measurements, we find that the orientation of the bases is in the anti region and that the sugar puckering is in the 2'-endo range.(ABSTRACT TRUNCATED AT 250 WORDS)
Free-radical oxidation of organic phosphonic acid salts in water using hydrogen peroxide, oxygen, and ultraviolet light (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFree-radical oxidation of organic phosphonic acid salts in water using hydrogen peroxide, oxygen, and ultraviolet lightTheodore Mill and Constance W. GouldCite this: Environ. Sci. Technol. 1979, 13, 2, 205–208Publication Date (Print):February 1, 1979Publication History Published online1 May 2002Published inissue 1 February 1979https://pubs.acs.org/doi/10.1021/es60150a014https://doi.org/10.1021/es60150a014research-articleACS PublicationsRequest reuse permissionsArticle Views298Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Robust GMM Based Gender Classification using Pitch and RASTA-PLP Parameters of Speech (2006)

A novel gender classification system has been proposed based on Gaussian mixture models, which apply the combined parameters of pitch and 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> order relative spectral perceptual linear predictive coefficients to model the characteristics of male and female speech. The performances of gender classification system have been evaluated on the conditions of clean speech, noisy speech and multi-language. The simulations show that the performance of the proposed gender classifier is excellent; it is very robust for noise and completely independent of languages; the classification accuracy is as high as above 98% for all clean speech and remains 95% for most noisy speech, even the SNR of speech is degraded to OdB
Transcriptional diversity during lineage commitment of human blood progenitors (2014)

Blood cells derive from hematopoietic stem cells through stepwise fating events. To characterize gene expression programs driving lineage choice, we sequenced RNA from eight primary human hematopoietic progenitor populations representing the major myeloid commitment stages and the main lymphoid stage. We identified extensive cell type-specific expression changes: 6711 genes and 10,724 transcripts, enriched in non-protein-coding elements at early stages of differentiation. In addition, we found 7881 novel splice junctions and 2301 differentially used alternative splicing events, enriched in genes involved in regulatory processes. We demonstrated experimentally cell-specific isoform usage, identifying nuclear factor I/B (NFIB) as a regulator of megakaryocyte maturation-the platelet precursor. Our data highlight the complexity of fating events in closely related progenitor populations, the understanding of which is essential for the advancement of transplantation and regenerative medicine.
Modification of the carboxyl terminal group affects replacement set analysis of a cytotoxic T cell epitope. (1996)

An Epstein-Barr virus-specific cytotoxic T cell (CTL) clone was previously shown to recognize the epitope FLRGRAYGL. The ability of substituted peptides to sensitize target cells for lysis by this clone was investigated using two peptide replacement sets, one synthesized with free carboxyl termini and another made with a carboxyl terminal beta-alanine-diketopiperazine (beta A-DKP) group. Curiously, the effect of certain substitutions differed for the two peptide sets. For example, NH2-FLRGRAYGL-beta A-DKP was 15-fold more active than NH2-FLRGRAYGI-beta A-DKR, but NH2-FLRGRAY-GL-COOH had the same activity as NH2-FLRGRAYGI-COOH. Evidence presented here illustrates that the activity of beta A-DKP peptide preparations was entirely due to contaminating peptides with free-COOH termini. The amount of active-COOH contaminants within a -beta A-DKP preparation thus appeared to vary depending on the substitution, resulting in some anomalous results from replacement set analysis using -beta A-DKP peptides.
A 250 MHz dual port cursor RAM using dynamic data alignment architecture (2002)

This paper describes a dual port cursor RAM operating in real time. Cursor RAMs have been composed of two memory planes. The pixel port requires data from both planes at the same time. However, this has not been realized so far because each port defines its address space differently. A dynamic data alignment architecture coordinates these different requests. This architecture reduces a large amount of control circuits and makes it possible to operate in real time. The RAM is fabricated in a double metal 0.5 /spl mu/m CMOS process technology. The active area is 1.5/spl times/1.6 mm including a couple of shift registers. It operates up to 263 MHz at the supply voltage of 3.3 V.
Metabolism of the Third Component of Complement (C3) in Normal Human Subjects (1974)

1. A single, biologically active, highly purified preparation of the third component of complement (C3) has been used to study C3 metabolism in eleven normal subjects. 2. Half-life of the radioactive protein ranged from 64 to 81 h with fractional catabolic rates (FCR) of 1·36–1·95% of the plasma pool/h. Extravascular/intravascular pool ratios were 0·19–0·55. 3. Analysis of plasma and extravascular radioactivity curves suggested that the primary site of C3 metabolism was intravascular.
Effect of bismuth subgallate (local hemostatic agent) on wound healing in rats. Histological and histometric findings. (2002)

The aim of this research was to evaluate the effect of bismuth subgallate on wound healing. In 40 Wistar rats, two standard wounds (3.5 mm x 2 mm) were made using a biopsy punch on the back of each animal. Test wounds were filled with bismuth subgallate and control wounds with 0.9% saline. At 1, 4, 7, 11 and 18 days, the qualitative evolution of the granulation tissue morphology was observed and digitalized histologic images were evaluated. There were no significant histological differences between test and control. Histometrically, there were statistically significant differences between test and control (ANOVA--days 1 and 4; Student t test, p < 0.05--days 7, 11 and 18) in terms of the following parameters: area of ulceration--day 1; distance between epithelial edges--day 4; area of granulation tissue--days 7, 11 and 18. It was concluded that bismuth subgallate is biocompatible to the healing tissue, and did not interfere with the normal development of wound healing.
PRESENT SITUATION OF RESEARCH AND DEVELOPMENT OF TOURMALINE AND ITS APPLICATION FUTURE AT HOME AND ABROAD (2004)

This paper outlines present situation of research and development of tourmaline in the areas of water treatment,decontamination and clarification,medicinal and health care,filling-,acoustic-,electric-materials as well as paint and grinding abrasives,expounds the relationship between physicochemical properties and usage of tourmaline minerals and looks forward to the potentials of its application in various fields
Subsea instrument deployments: methodology and techniques using a work class remotely operated vehicle (ROV) (2002)

The conventional deployment of sensors and data-logging equipment by free fall from the ocean's surface is fraught with many technical problems, including unpredictable instrument placement, lack of control over site selection, unreliable instrument orientation, lack of communications with the instrument during deployment, and short measurement duration due to limited battery power. Through several experiments, MBARI has attempted to reduce or eliminate the impact of a number of these problems by utilizing the communicative and manipulative capabilities of the ROV Ventana. The development of corehole seismometers required methods to maintain the connection to a data logger during the deployment, and then allow in situ connection of the logger to an instrument to verify data collection and integrity in real time. The Monterey Bay Ocean Bottom International Seismic Experiment (MOISE) allowed for specific site selection and preparation prior to instrument deployment, real-time data access, control and verification of instrument and data integrity, and the ability to revisit the site to access both the instrument and data logger as well as supply additional power. The Autonomous Video Camera System (AVCS) allows selection of sites or subject matter for long-term video observation with the ability to verify the operation and target subject prior to disconnection of the ROV from the camera system. The One- and Two-Meter Hydraulic Tube Coring experiments allowed for precise placement and controlled execution of sediment coring operations. The preceding are some development efforts that demonstrate how technical and methodological problems were approached. By the very nature of the solutions, new questions have arisen and more advanced methods of achieving technical goals are being pursued.
Epitopes of Bordetella pertussis lipopolysaccharides as potential markers for typing of isolates with monoclonal antibodies (1996)

Three hybridomas (P1P3, D7 and 60.5) producing monoclonal antibodies (mAbs) against Bordetella pertussis lipopolysaccharide (LPS) were established. All reacted with the LPS from a typical, vaccine strain of B. pertussis (1414), but not with that of a variant strain (A100). Two of these mAbs (P1P3 and 60.5) cross-reacted with a B. bronchiseptica LPS; only one (P1P3) reacted with a B. parapertussis LPS. ELISA reactivities with intact LPSs, and defined partial structures covalently linked to bovine serum albumin, were compared. mAb 60.5 bound to the terminal region of a distal trisaccharide consisting of N-acetylated amino sugars. D7 reacted with a substructure which can be modified in the B. parapertussis and B. bronchiseptica LPSs by addition of a polymeric O-chain. P1P3 bound to a nonacetylated glucosamine substituted with L-glycero-D-manno-heptose, present in the 'core' of the B. pertussis LPS. These mAbs may be useful for rapid typing of Bordetella in clinical isolates.
How Computers Work: Processor and Main Memory (2002)

Computers are the most complex machines that have ever been created. This book will tell you how they work, and no technical knowledge is required. It explains in great detail the operation of a simple but functional computer. Although transistors are mentioned, relays are used in the example circuitry for simplicity. Did you ever wonder what a bit, a pixel, a latch, a word (of memory), a data bus, an address bus, a memory, a register, a processor, a timing diagram, a clock (of a processor), an instruction, or machine code is? Unlike most explanations of how computers work which are a lot of analogies or require a background in electrical engineering, this book will tell you precisely what each of them is and how each of them works without requiring any previous knowledge of computers, programming, or electronics. This book starts out very simple and gets more complex as it goes along, but everything is explained. The processor and memory are mainly covered.
Two-photon absorption and self-phase modulation in InGaAsP/InP multi-quantum-well waveguides (1991)

We report the first measurement of two-photon absorption (TPA) and self-phase modulation in an InGaAsP/InP multi-quantum-well waveguide. The TPA coefficient, β2, was found to be 60±10 cm/GW at 1.55 μm. Despite operating at 200 nm from the band edge, self-phase modulation as high as 8±2 rad was observed for 30-ps optical pulses at 3.8-W peak input power. A theoretical calculation indicates that this enhanced phase modulation is primarily due to bandfilling in the quantum wells and the free-carrier plasma effect.