gebhart/patrepeval huggingface dataset:
Hepatic Lipase Gene Variant −514C&gt;T Is Associated With Lipoprotein and Insulin Sensitivity Response to Regular Exercise (2005)

We investigated the associations between the hepatic lipase gene (LIPC) −514C&gt;T polymorphism and lipases, lipoproteins, and insulin sensitivity (Si) responses to exercise training. Hepatic lipase and lipoprotein lipase activities, plasma lipoprotein levels, and Si were measured in the sedentary state and post–exercise training in the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study (n = 662). The LIPC −514C allele frequency was 0.516 (blacks) and 0.796 (whites). Baseline and post–exercise training hepatic lipase activities were 40% higher in CC homozygotes (P &lt; 0.0001) in both races. Black CC homozygotes had lower baseline lipoprotein lipase activity, HDL cholesterol, HDL3, and apolipoprotein (apo)A-1 concentrations. White CC homozygotes had lower baseline HDL cholesterol, apoA-1, LDL cholesterol, and apoB levels that remained low post–exercise training. Baseline Si was not associated with the LIPC genotypes. However, training-induced improvements in Si both in blacks and whites were greater in CC homozygotes (+1.25 ± 0.2 and +0.22 ± 0.2 μU · min−1 · ml−1) than in the TT genotype (+0.27 ± 0.3 and −0.97 ± 0.3 μU · min−1 · ml−1) (P = 0.008 and P = 0.002, respectively). The LIPC −514C allele was associated with higher hepatic lipase activity in sedentary and physically active states and better Si responses to regular exercise both in black and white individuals. The benefits from an exercise program on Si are likely to be substantial in the general population given the high frequency of the LIPC −514C allele, particularly in whites.
Predictive Analytics for Event Stream Processing (2019)

Historical data contained in event logs can reveal important insights about the execution of a business process. In particular, the trends computed by processing and analyzing the sequence of events generated by multiple instances of the same process serve as the basis to produce forecasts about current executions of the process. In this paper, we join the concepts of event stream processing and machine learning to create a framework that allows the computation of various kinds of predictions on event logs. The proposed framework is generic: by providing different definitions to a handful of event functions, multiple different types of predictions can be computed using the same basic workflow. The approach has been implemented and experimentally evaluated by extending an existing event stream processing engine.
Autoradiographic Localization of the GABA<sub>A</sub> Receptor Agonist [<sup>3</sup>H]-Muscimol within Rat Kidney (1988)

By the use of combined radioreceptor binding and autoradiographic techniques, the pharmacological characteristics of (3H)-muscimol binding and the localization of the label were studied. (3H)-Muscimol was bound by sections of rat kidney in a manner consistent with the existence of specific gamma-aminobutyric acid 'A' (GABAA) receptors with KD and Bmax values of 23.7 nmol/l and 1.15 pmol/mg tissue, respectively. (3H)-Muscimol was bound by convoluted tubules of the renal cortex and by the collecting tubules. Our findings demonstrating the existence of recognition sites for the GABAA receptor agonist muscimol in the kidney suggest that GABA has a role in renal function.
Gandoderma lucidum extract promotes immune responses in normal BALB/c mice In vivo. (2009)

Enhanced fruit and vegetable consumption is closely related to reduced cancer incidence as shown in epidemiological studies. Ganoderma lucidum, one of the most well-known traditional Chinese medicines, has been demonstrated to have pharmacological activities and antitumor effects, in Asian populations. However, the promotion of immune responses in normal BALB/c mice is unclear. In the present study, we investigated the immune responses of BALB/c mice after treatment with G. lucidum extract in vivo. The results demonstrated that G. lucidum extract was able to promote the proliferation of splenocytes under Concanavalin A or lipopolysaccharide stimulation. Compared with the control group, phagocytosis of macrophage was significantly enhanced by intraperitoneal administration of G. lucidum extract at both 3 and 6 mg/kg. Compared with the control group, natural killer cell activity was significantly enhanced by intraperitoneal administration of G. lucidum extract (6 mg/kg). Results of cytometric bead array and flow cytometry indicated that the expressions of interleukin-6 and interferon-gamma also increased (p<0.001) by treatment with G. lucidum extract (3 and 6 mg/kg). In conclusion, the findings of this study implied that G. lucidum extract was able to effectively promote immune responses in BALB/c mice.
Metal-Modified Base Pairs Involving Different Donor Sites of Purine Nucleobases: <i>trans</i>-[a<sub>2</sub>Pt(7,9-DimeG-<i>N1</i>)(9-EtGH-<i>N7</i>)]<sup>2+</sup>and<i>trans</i>-[a<sub>2</sub>Pt(7,9-DimeG-<i>N1</i>)(9-EtG-<i>N7</i>)]<sup>+</sup>(a = NH<sub>3</sub>or CH<sub>3</sub>NH<sub>2</sub>; 9-EtGH = 9-Ethylguanine; 7,9-DimeG = 7,9-Dimethylguanine). Possible Relevance to Metalated DNA Triplex Structures (1999)

The X-ray crystal structures of four mixed-nucleobase complexes 1a, 1b, 2, and 4 of trans-a2PtII (a = NH3 or CH3NH2) with N1-bonded 7,9-dimethylguanine (7,9-DimeG) and N7-bonded 9-ethylguanine (9-EtGH) are reported. The compounds are discussed in terms of their possible model character for platinated nucleobase triplets of the pu × pu·pym (pu = purine, pym = pyrimidine) type and are compared with known guanine·guanine pairs. Structural differences resulting from a “metal modification” have been studied, as have been stacking and H bonding motifs. 1a and 1b are two modifications of the same compound, trans-[(NH3)2Pt(7,9-DimeG)(9-EtGH)](ClO4)2·H2O. X-ray data for 1a: orthorhombic, Pca21, a = 13.833(3) Å, b = 14.357(3) Å, c = 13.293(3) Å, Z = 4, R = 0.027. 1b: monoclinic, P21/n, a = 13.987(3) Å, b = 12.582(3) Å, c = 15.613(3) Å, β = 104.61(3)°, Z = 4, R = 0.034. trans-[(CH3NH2)2Pt(7,9-DimeG)(9-EtGH)](ClO4)2 (2): orthorhombic, Pca21, a = 13.886(1) Å, b = 14.698(1) Å, c = 13.008(3) Å, Z = 4, R = 0.034. trans-[a2Pt(7,9-DimeG)(9-EtG)](ClO4)·nH2O (3, a = NH3, n = 2; 4, a = CH3NH2, n = 3). X-ray data for 4: monoclinic, C2/c, a = 23.296(5) Å, b = 10.566(2) Å, c = 22.327(4) Å, β = 93.73(3)°, Z = 8, R = 0.047. The metalated base triplet 2·(1-MeC) (1-MeC = 1-methylcytosine) has been detected in DMSO-d6 solution through 1H NMR spectroscopy, and an ab initio optimized structure of an analogous platinated base triplet has been obtained.
Coercivity map of perpendicular patterned CoCrPt medium investigated by using MFM (2004)

Magnetic force microscopy (MFM) analyses were done to investigate the magnetization reversal behaviour of a perpendicular patterned CoCrPt medium. The medium was observed by using in-situ (in the presence of perpendicular field up to 5.5 kOe) and ex-situ (in the absence of external field) MFM techniques. Magnetization state, coercivity and magnetostatic energy of the individual magnetic dots were studied in a given microscopic area. Taking account of the magnetostatic energy for the respective nanomagnets, the maps of the experimental and intrinsic coercivities for this region were obtained. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Recommendations for managing vital-organ donors (1999)

This chart describes some clinical problems organ donors may face, how the nurse should intervene, and the rationale for the intervention. The recommendations were developed by Corrinne Morgan, RN, CCRN, CNRN, for the Delaware Valley, Pa., transplant program, which serves eastern Pennsylvania, southern, New Jersey, and Delaware.
The synthesis of imidazo[4,5‐<i>c</i>] ‐ and <i>v</i>‐triazolo[4,5‐<i>c</i>] pyridazines (1967)

Abstract The parent imidazo[4,5‐ c ]pyridazine (IV) has been prepared for the first time by three different routes. 1‐Methylimidazo[4,5‐ c ]pyridazine (XX) and 3‐methylimidazo[4,5‐ c ]pyridazine (XXVII) have been prepared by unequivocal syntheses. The constitution of the methylation product of imidazo[4,5‐ c ]pyridazine‐2‐thiol (VIII) has been shown to be 2‐methylthioimidazo[4,5‐ c ]‐pyridazine (IX) by the unequivocal syntheses of 1‐methylimidazo[4,5‐ c ]pyridazine‐2‐thiol (XXIII) and 3‐methylimidazo[4,5‐ c ]pyridazine‐2‐thiol (XXXIII). Likewise, the structure of the methylation product (XIII) was shown to be S ‐methylation by the unequivocal syntheses of 1‐methyl‐2‐methylthio‐6‐chloroimidazo[4,5‐ c ]pyridazine (XXIV) and 3‐methyl‐2‐methylthio‐6‐chloroimidazo[4,5‐ c ]pyridazine (XXXI), respectively. Several 7‐substituted amino‐ v ‐triazolo‐[4,5‐ c ]pyridazines (XXXVIII) have been prepared from 7‐chloro‐ v ‐triazolo[4,5‐ c ]pyridazine (XXXVII).
The pressure gradient in the human respiratory tract (2014)

Respiratory airways cause resistance to air flow during inhalation and exhalation. The pressure gradient is necessary to transport the air from the mount (or nose) to pulmonary alveoli. The knowledge of pressure gradient (i.e. respiratory airways resistance) is also needed to solve the question of aerosol deposition in the human respiratory tract. The obtained data will be used as boundary conditions for CFD simulations of aerosol transport. Understanding of aerosol transport in the human lungs can help us to determine the health hazard of harmful particles. On the other hand it can be used to set the conditions for transport of medication to the desirable place. This article deals with the description of the mathematical equations defining the pressure gradient and resistance in the bronchial three and describes the geometry used in the calculation.
Emotion-sensitive human-computer interfaces (2000)

People are polite to their computers. They are flattered by them, form teams with them and even interact emotionally with them. In their experiments, Reeves and Nass (The Media Equation, 1996) showed that humans impose their interpersonal behavioral patterns onto their computers. Thus, the design of humancomputer interfaces should reflect this observation in order to facilitate an effective communication. In order to build a human-computer interface that is sensitive to the user's expressed emotion, we investigated spectral, prosodic, and verbal cues in the user's utterance. Based on these cues, we showed that the classification system achieved accuracies comparable to human performance. Finally, we demonstrate how to integrate information about the expressed emotion into a dialog system. The dialog system employs different discourse strategies depending on the expressed emotion allowing for a natural and effective communication between the user and the system.
Chromatin remodelling complex dosage modulates transcription factor function in heart development (2011)

Dominant mutations in cardiac transcription factor genes cause human inherited congenital heart defects (CHDs); however, their molecular basis is not understood. Interactions between transcription factors and the Brg1/Brm-associated factor (BAF) chromatin remodelling complex suggest potential mechanisms; however, the role of BAF complexes in cardiogenesis is not known. In this study, we show that dosage of Brg1 is critical for mouse and zebrafish cardiogenesis. Disrupting the balance between Brg1 and disease-causing cardiac transcription factors, including Tbx5, Tbx20 and Nkx2-5, causes severe cardiac anomalies, revealing an essential allelic balance between Brg1 and these cardiac transcription factor genes. This suggests that the relative levels of transcription factors and BAF complexes are important for heart development, which is supported by reduced occupancy of Brg1 at cardiac gene promoters in Tbx5 haploinsufficient hearts. Our results reveal complex dosage-sensitive interdependence between transcription factors and BAF complexes, providing a potential mechanism underlying transcription factor haploinsufficiency, with implications for multigenic inheritance of CHDs.
ELFies: Executable Region Checkpoints for Performance Analysis and Simulation (2021)

We address the challenge faced in characterizing long-running workloads, namely how to reliably focus the detailed analysis on interesting execution regions. We present a set of tools that allows users to precisely capture any region of interest in program execution, and create a stand-alone executable, called an ELFie, from it. An ELFie starts with the same program state captured at the beginning of the region of interest and then executes natively. With ELFies, there is no fast-forwarding to the region of interest needed or the uncertainty of reaching the region. ELFies can be fed to dynamic program-analysis tools or simulators that work with regular program binaries. Our tool-chain is based on the PinPlay framework and requires no special hardware, operating system changes, recompilation, or re-linking of test programs. This paper describes the design of our ELFie generation tool-chain and the application of ELFies in performance analysis and simulation of regions of interest in popular long-running single and multi-threaded benchmarks.
Fundamentals of Friction: Macroscopic and Microscopic Processes. Proceedings of the NATO Advanced Study Institute on Fundamentals of Friction Held In Germany on July 29 - August 9, 1991 (1991)

This report describes what is known about friction from models and experiments on a macroscopic scale, and what is being learned at the microscopic level. The book is a synthesis of the material from lectures, discussions and workshops. Although other relevant aspects of tribology, such as contact mechanics, surface treatments, and wear behavior, are reported, the emphasis here is on defining the state of knowledge and the gaps in understanding of friction processes.
N-type doping of organic electron transport materials for solar cells (2004)

To realize organic solar cells with high performance, we developed a novel way of stable n-doping using cationic dyes in electron transport materials. In our approach, the volatile donors are created in-situ from stable precursor compounds. Using the cationic dye pyronin B (PyB) as a model precursor, we carried out conductivity and field effect measurements to characterize the properties of doped naphtalene tetracarboxylic dianhydride (NTCDA) thin film. The results show a strong increase in n-type conductivity. Combined FTIR, UV/VIS/NIR and mass spectroscopic measurements suggest the formation of leuco pyronin B during sublimation of pyronin B chloride, and a subsequent charge transfer between dopant and matrix providing free electrons, which increase the n-type conductivity.
An Outbreak of Gastroenteritis Associated with Acute Rotaviral Infection in Schoolchildren (1989)

In April 1988 a large outbreak of group C rotavirus infection associated with acute gastroenteritis occurred among schoolchildren and their teachers simultaneously at seven elementary schools in Fukui city, Japan. Of 3,102, 675 (21.8%) became ill. Clinical symptoms were mild, predominantly abdominal pain and vomiting, with diarrhea reported in only 27.6%. The outbreak subsided within 2 d. No pathogenic bacteria were found in fecal specimens; the virus particles detected by electron microscopy were morphologically indistinguishable from conventional infantile rotavirus. Immune electron microscopy showed that these virions formed large aggregates with convalescent serum and with the reference serum specific to group C rotavirus. Polyacrylamide gel electrophoresis showed similar RNA patterns for virus from this outbreak and typical group C rotavirus.
SOUNDSERVER: DATA SONIFICATION ON-DEMAND FOR COMPUTATIONAL INSTANCES (2004)

The rapid accumulation of large collections of data has created the need for efficient and intelligent schemes for knowledge extraction and results analysis. The resulting information is typically visualized, but it may also be presented through audio techniques such as sonification. Sonification techniques become especially interesting when the client application runs on graphically limited devices such as mobile phones or PDAs (Personal Digital Assistants). In this paper we present an architecture for a sonification server that will be used in the Sound Data Mining project. In this project sound will be used to increase perception and present information extracted by spatial data mining techniques. The server is based on an audio synthesis engine and will relieve clients with little audio synthesis capabilities from the burden of sound processing. By providing sonification modules, this server can potentially be used on a variety of applications where sonification techniques are required.
Phase and crystallization behavior of solution‐blended poly(ether ether ketone) and poly(ether imide) (1992)

Abstract Results on solution‐blended poly(ether ether ketone) (PEEK) and poly(ether imide) (PEI) blends are reported. Dichloroacetic acid was used as the cosolvent for blending. PEEK and PEI are confirmed to be miscible in the melt. The glass transition, T g , behavior obeys the simple Fox equation or the Gordon‐Taylor equation with the adjustable coefficient k = 0.86. This agrees with prior data on melt‐blended PEEK/PEI blends. The T g width of the amorphous PEEK/PEI blends was found to be broader than that of the pure components. The maximum broadening is about 10°C. The specific volume of the amorphous PEEK/PEI blends shows a slight negative deviation from linearity, indicating favorable interaction between PEEK and PEI. The spherulitic growth and resultant blend morphology at 270°C were studied by a cross‐polarized optical microscope. The radial growth rate of PEEK spherulites formed from the miscible melt at 270°C decreases from 3.04 μm/min for PEEK/PEI 90/10 blend to 0.77 μm/min for PEEK/PEI 70/30 blend. The decrease in crystalization rate of PEEK from PEEK/PEI blends is attributable to the increase in blend T g . A linear growth was observed for PEEK spherulites formed from miscible melt at 270°C in the early growth stage. The spherulitic growth deviated from linearity in the late stage of growth. PEEK spherulites formed from the miscible PEEK/PEI melt at 270°C are essentially volume‐filling. The branches of the spherulites become more clear for PEEK spherulites formed from the blend than that formed from pure PEEK melt.
Selective inhibition of TNF-α-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib (2005)

We have reported that the selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, gefitinib ('Iressa', ZD1839), suppressed intrahepatic metastasis of hepatocellular carcinoma CBO140C12 cells. In this study, we focused on the tumour necrosis factor-alpha (TNF-alpha) signalling pathways. Real-time reverse transcription-polymerase chain reaction showed that TNF-alpha mRNA was expressed in large quantities in the implanted tumour. Gefitinib inhibited EGF- but not hepatocyte growth factor (HGF)-induced activation of mitogen-activated protein kinase (MAPK) cascades, suggesting selectivity of the inhibitor. However, gefitinib inhibited the TNF-alpha-induced activation of MAPKs and Akt. In addition, TNF-alpha-induced metastatic properties including adhesion to fibronectin, mRNA expression of integrin alpha v, production of matrix metalloproteinase-9 and invasion were inhibited by gefitinib without affecting cell proliferation. Furthermore, the TNF-alpha-induced responses except for NF-kappaB activation were blocked by metalloprotease inhibitors, suggesting that gefitinib inhibited the transactivation of EGFR induced by TNF-alpha. These results suggest that the TNF-alpha signalling pathway is a possible target of gefitinib in suppressing the intrahepatic metastasis of hepatocellular carcinoma.
Block copolymer self-assembly in selective solvents: theory of solubilization in spherical micelles (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBlock copolymer self-assembly in selective solvents: theory of solubilization in spherical micellesR. Nagarajan and K. GaneshCite this: Macromolecules 1989, 22, 11, 4312–4325Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/ma00201a029https://doi.org/10.1021/ma00201a029research-articleACS PublicationsRequest reuse permissionsArticle Views1258Altmetric-Citations151LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Epistatic Interaction Between β <sub>2</sub> -Adrenergic Receptor and Neuropeptide Y Genes Influences LDL-Cholesterol in Hypertension (2004)

Beta2-adrenergic receptor gene and neuropeptide Y gene may potentially influence lipid metabolism and overall energy balance. Therefore, we examined associations of these genes with lipid fractions and obesity-related phenotypes in hypertensive subjects. A total of 638 white individuals from 212 Polish families with clustering of essential hypertension were phenotyped for cardiovascular risk determinants. Each subject was genotyped for functional polymorphisms of beta2-adrenergic receptor gene (Arg16Gly and Gln27Glu) and neuropeptide Y (Leu7Pro). Of 3 common haplotypes of beta2-adrenergic receptor gene, Arg16Gln27 was overtransmitted to offspring with elevated levels of total cholesterol (Z=2.2; P=0.026) and LDL-cholesterol (Z=3.2; P=0.002). Individually, Leu7Pro was not associated with any of the metabolic phenotypes in family-based tests or case-control analyses. However, in the presence of Arg allele of Arg16Gly and Gln allele of Gln27Glu, homozygosity for Leu variant of the Leu7Pro polymorphism was associated with 2.1-increased odds ratio (confidence interval, 1.10 to 3.81; P=0.024) of elevated LDL in hypertensive subjects, independent of age, gender, body mass index, adjusted blood pressures, antihypertensive therapy, and use of nonselective beta-blockers and diuretics. Consistently, there was a significant multilocus association among variants of Arg16Gly, Gln27Glu, and Leu7Pro in hypertensive probands with elevated LDL (cases; P=0.028) but not in hypertensive subjects with normal LDL (controls). This study revealed an association of LDL-cholesterol with beta2-adrenergic receptor gene haplotype and provided evidence for epistatic interaction between beta2-adrenergic receptor gene and neuropeptide Y gene in determination of LDL-cholesterol in patients with essential hypertension.