gebhart/patrepeval huggingface dataset:
Oral Immunotherapy of Children with Rhinoconjunctivitis due to Birch Pollen Allergy A Double Blind Study (1986)

Thirty children with rhinoconjunctivitis due to birch pollinosis were treated in a double blind manner for 10 months with enteric-coated capsules containing either a birch pollen preparation (n = 14) with doses up to 1.4 X 10(6) biologic units per day or placebo (n = 16). Compared with the placebo group the actively treated children had less symptoms during the birch pollen season after 3 months of therapy (P = 0.035). Skin prick reactions decreased significantly more in the active group than in the placebo group after 10 months (P = 0.01). Conjunctival sensitivity was lower in the active group than in the placebo group after 3 months of treatment (P = 0.01) but not after 10 months. Compared with the placebo group the treated children more often increased their levels of IgG (P = 0.007) and pre-seasonal IgE (P = 0.001) against birch. There was a seasonal increase of IgE antibody level against birch in the placebo but not in the treatment group (P less than 0.001). None of the treated children developed asthma, compared with five of the untreated children. No general reactions occurred and few side effects were seen during the treatment period. We conclude that in children with birch pollinosis oral immunotherapy with high doses of a biologically potent preparation in enteric-coated capsules is effective, easy to perform, economic and safe.
Conformations of Silica-Bound (Pentafluorophenyl)propyl Groups Determined by Solid-State NMR Spectroscopy and Theoretical Calculations (2010)

The conformations of (pentafluorophenyl)propyl groups (-CH(2)-CH(2)-CH(2)-C(6)F(5), abbreviated as PFP), covalently bound to the surface of mesoporous silica nanoparticles (MSNs), were determined by solid-state NMR spectroscopy and further refined by theoretical modeling. Two types of PFP groups were described, including molecules in the prone position with the perfluorinated aromatic rings located above the siloxane bridges (PFP-p) and the PFP groups denoted as upright (PFP-u), whose aromatic rings do not interact with the silica surface. Two-dimensional (2D) (13)C-(1)H, (13)C-(19)F and (19)F-(29)Si heteronuclear correlation (HETCOR) spectra were obtained with high sensitivity on natural abundance samples using fast magic angle spinning (MAS), indirect detection of low-gamma nuclei and signal enhancement by Carr-Purcell-Meiboom-Gill (CPMG) spin-echo sequence. 2D double-quantum (DQ) (19)F MAS NMR spectra and spin-echo measurements provided additional information about the structure and mobility of the pentafluorophenyl rings. Optimization of the PFP geometry, as well as calculations of the interaction energies and (19)F chemical shifts, proved very useful in refining the structural features of PFP-p and PFP-u functional groups on the silica surface. The prospects of using the PFP-functionalized surface to modify its properties (e.g., the interaction with solvents, especially water) and design new types of the heterogeneous catalytic system are discussed.
RECRUITMENT OF ENGRAFTED DONOR CELLS POSTNATALLY INTO THE BLOOD WITH CYTOKINES AFTER IN UTERO TRANSPLANTATION IN MICE1 (1997)

Adult bone marrow durably engrafts in nondefective mice at a rate similar to that previously obtained with fetal liver. Engrafted donor cells can be mobilized with cytokines into the circulation for up to 2 months even in animals with no evidence of donor cells in the blood, liver, or spleen. Based on these results we estimate that 70-75% of hematopoietically nondefective fetal mice engraft with MHC-mismatched fetal liver or adult bone marrow stem cells.
DCNP: data communication management system for network node processors in a distributed processing environment (2003)

Network node processors (NNPs), which can execute application programs and can cooperate with each other via high-speed LANs, have become essential components for distributed online systems. DCNP is a data communication management system for NNP. DCNP provides unified communication interfaces and high-performance and highly reliable communication services. An addressing technique which unifies program interfaces for node-to-terminal communications and internode communications is presented. Socket interface extensions for improving performance and techniques for highly reliable internode multicast communications on multiple LANs are also presented. DCNP has been implemented with a Unix kernel on fault-tolerant minicomputers and is operating in online systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Abstract B032: Targeting the PD-1/PD-L1 immune evasion axis with DNA aptamers (2016)

Abstract Blocking the immunoinhibitory PD-1:PD-L1 pathway using monoclonal antibodies has led to dramatic clinical responses by reversing tumor immune evasion and provoking robust and durable anti-tumor responses. Anti-PD-1 antibodies have now been approved for the treatment of melanoma, and are being clinically tested in a number of other tumor types as both a monotherapy and as part of combination regimens. Here, we report the development of DNA aptamers as synthetic, non-immunogenic antibody mimics, which bind specifically to the murine extracellular domain of PD-1 and block the PD-1:PD-L1 interaction. These aptamers did not bind to closely related proteins including human PD-1. One such aptamer, MP7, functionally inhibits the PD-L1-mediated suppression of IL-2 secretion in primary murine T-cells. A PEGylated form of MP7 retains the ability to block the PD-1:PD-L1 interaction, and significantly suppresses the growth of PD-L1+ colon carcinoma cells in-vivo with a potency equivalent to an antagonistic anti-PD-1 antibody. Importantly, the anti-PD-1 DNA aptamer treatment was not associated with off-target TLR-9-related immune responses. Due to the inherent advantages of aptamers including their lack of immunogenicity, low cost, long shelf life, and ease of synthesis, such PD-1 antagonistic aptamers may represent an attractive alternative over antibody-based anti PD-1 therapeutics. Citation Format: Aaron Prodeus, Jean Gariepy. Targeting the PD-1/PD-L1 immune evasion axis with DNA aptamers. [abstract]. In: Proceedings of the CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(1 Suppl):Abstract nr B032.
Use of Sentiment Analysis for Capturing Patient Experience From Free-Text Comments Posted Online (2013)

The prediction accuracy that we have achieved using this machine learning process suggests that we are able to predict, from free-text, a reasonably accurate assessment of patients' opinion about different performance aspects of a hospital and that these machine learning predictions are associated with results of more conventional surveys.
Interaction between the Rayleigh-type SAW and the SH-wave in a periodic grating on a 128&#x00B0;-LN substrate (2010)

Ladder-type filters employing SAW resonators demand high Q-factors at both the resonance and anti-resonance frequencies. Also, spurious-free, low-loss response is especially important for novel filters having multiple passband modes in which one or more of the passbands is far from the resonant frequency of a SAW device. 128° LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> is traditionally considered as a substrate in which SH-SAW modes are very weakly coupled to transducer electric fields and thus it may provide a good avenue for improving SAW resonator loss performance. We have experimentally studied a large number of synchronous SAW resonators on 128° LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> substrate with different aluminum relative thickness (h/ λ ) and resonant frequencies near 900MHz. All theoretical modeling of the resonators was performed using the FEM/BEM simulation tool FEMSAW. In almost all measured devices and FEMSAW simulations we observed an interaction of the SAW with another acoustic mode. However, the very weak coupling of the IDT to the SH-SAW mode does not explain the data. The observed interaction is likely to be due to mechanical scattering of the strongly excited Rayleigh-type SAW into a shear SAW.
Customer lifetime value prediction by a Markov chain based data mining model: Application to an auto repair and maintenance company in Taiwan (2012)

The present study attempts to establish a framework for computing customer lifetime values for a company in the auto repair and maintenance industry. The customer lifetime value defined in this study consists of the current and future values of a customer, which involve an estimation of lifetime length, future purchasing behavior and the profit associated with each behavior of the customer. The proposed framework contains three groups of techniques to obtain these estimates from historical customer transactions. The first group includes a logistic regression model and a decision tree model to estimate the churn probability of a customer and to, further, predict the lifetime length of the customer. The second group comprises a regression analysis to identify the critical variables that affect a customer’s purchasing behavior, and a Markov chain to model the transition probabilities of behavior change. Finally, the third group contains two neural networks to predict the profits contributed by a customer under various purchasing behaviors. The proposed framework is demonstrated with the historical customer transactions of an auto repair and maintenance company in Taiwan.
[Discriminant Analysis of Lavender Essential Oil by Attenuated Total Reflectance Infrared Spectroscopy]. (2016)

This work aimed to use attenuated total reflectance Fourier transform infrared spectroscopy to identify the lavender essential oil by establishing a Lavender variety and quality analysis model. So, 96 samples were tested. For all samples, the raw spectra were pretreated as second derivative, and to determine the 1 750-900 cm(-1) wavelengths for pattern recognition analysis on the basis of the variance calculation. The results showed that principal component analysis (PCA) can basically discriminate lavender oil cultivar and the first three principal components mainly represent the ester, alcohol and terpenoid substances. When the orthogonal partial least-squares discriminant analysis (OPLS-DA) model was established, the 68 samples were used for the calibration set. Determination coefficients of OPLS-DA regression curve were 0.959 2, 0.976 4, and 0.958 8 respectively for three varieties of lavender essential oil. Three varieties of essential oil's the root mean square error of prediction (RMSEP) in validation set were 0.142 9, 0.127 3, and 0.124 9, respectively. The discriminant rate of calibration set and the prediction rate of validation set had reached 100%. The model has the very good recognition capability to detect the variety and quality of lavender essential oil. The result indicated that a model which provides a quick, intuitive and feasible method had been built to discriminate lavender oils.
New plasminogen activators: A clinical review (1999)

Rapid restoration of patency of the infarct-related artery is the key to preserving myocardium and improving survival. This understanding has led to the application of genetic engineering to develop new plasminogen activators with specific clinical features. These novel activators may provide faster and more complete reperfusion in a greater number of patients, and do so with less risk of bleeding and intracranial hemorrhage. This article reviews the pharmacologic profiles and clinical performance of several novel plasminogen activators engineered from the human tissue plasminogen activator molecule or developed from animal and bacterial proteins.
Asymmetric 1,4-Addition of Arylboronic Acids to α,β-Unsaturated Aldehydes Catalyzed by a Chiral Diene–Rhodium Complex (2005)

Abstract Asymmetric 1,4-addition of arylboronic acids to α,β-unsaturated aldehydes proceeded in the presence of a rhodium catalyst (3 mol %) coordinated with a chiral diene ligand ((R,R)-Bn-bod*) to give the corresponding β-arylaldehydes with perfect 1,4-selectivity and with 88–97% enantioselectivity.
Nitrogen Doped Germania Glasses with Enhanced Optical and Mechanical Properties (1997)

A new type of ultraviolet photosensitive germanium doped glass has been developed for use in the fabrication of optical waveguide structures.By adding ammonia to the source gases during a plasma enhanced chemical vapor deposition of these glasses, ultraviolet induced refractive index changes of up to 3.5 x io have been obtained.Although this is, to Nitrogen Doped Germania Glasses with Enhanced Optical and Mechanical Properties
Hexose Kinases and Their Role in Sugar-Sensing and Plant Development (2013)

Hexose sugars, such as glucose and fructose produced in plants, are ubiquitous in most organisms and are the origin of most of the organic matter found in nature. To be utilized, hexose sugars must first be phosphorylated. The central role of hexose-phosphorylating enzymes has attracted the attention of many researchers, leading to novel discoveries. Only two families of enzymes capable of phosphorylating glucose and fructose have been identified in plants; hexokinases (HXKs), and fructokinases (FRKs). Intensive investigations of these two families in numerous plant species have yielded a wealth of knowledge regarding the genes number, enzymatic characterization, intracellular localization, and developmental and physiological roles of several HXKs and FRKs. The emerging picture indicates that HXK and FRK enzymes found at specific intracellular locations play distinct roles in plant metabolism and development. Individual HXKs were shown for the first time to be dual-function enzymes - sensing sugar levels independent of their catalytic activity and controlling gene expression and major developmental pathways, as well as hormonal interactions. FRK, on the other hand, seems to play a central metabolic role in vascular tissues, controlling the amounts of sugars allocated for vascular development. While a clearer picture of the roles of these two types of enzymes is emerging, many questions remain unsolved, such as the specific tissues and types of cells in which these enzymes function, the roles of individual HXK and FRK genes, and how these enzymes interact with hormones in the regulation of developmental processes. It is anticipated that ongoing efforts will broaden our knowledge of these important plant enzymes and their potential uses in the modification of plant traits.
Photoinduced paramagnetic defects in amorphous silicon dioxide (1984)

Several paramagnetic defects are photoinduced in amorphous Si${\mathrm{O}}_{2}$ by sub-band-gap light. The resulting EPR spectrum changes dramatically as the excitation energy is varied, and is sensitive to the OH content of the material. A three-component resonance seen in high-OH-content Si${\mathrm{O}}_{2}$ is ascribed to a nitrogen-impurity-related defect.
Enhanced Oxygen Evolution at Hydrous Oxy-Hydroxide Modified Iron Electrodes in Aqueous Alkaline Solution (2011)

Outstanding issues regarding the film formation and the oxygen evolution reaction (OER) electrocatalytic behaviour of multicycled iron oxyhydroxide films in aqueous alkaline solution have been revisited. The oxide is grown using a repetitive poltential multicycling technique, and the mechanism of the latter hydrous oxide formation process has been discussed. A duplex layer model of the oxide/solution interphase region is proposed. The acid/base behaviour of the hydrous oxide and the microdispersed nature of the latter material has been emphasised. The hydrous oxide is considered as a porous assembly of interlinked octahedrally coordinated anionic metal oxyhydroxide surfaquo complexes which form an open network structure. The latter contains considerable quantities of water molecules which facilitate hydroxide ion discharge at the metal site during active oxygen evolution, and also charge compensating cations. The dynamics of redox switching has been quantified via analysis of the cyclic voltammetry response as a function of potential sweep rate using the Laviron-Aoki electron hopping diffusion model by analogy with redox polymer modified electrodes. Steady state Tafel plot analysis has been used to elucidate the kinetics and mechanism of oxygen evolution. Tafel slope values of ca. 60 mVdec-1 and ca. 120 mVdec-1 are found at low and high overpotentials respectively, whereas the reaction order with respect to hydroxide ion activity changes from ca. 3/2 to ca. 1 as the potential is increased. These observations are rationalised in terms of a kinetic scheme involving Temkin adsorption and the rate determining formation of a physisorbed hydrogen peroxide intermediate on the oxide surface. The dual Tafel slope behaviour is ascribed to the potential dependence of the surface coverage of adsorbed intermediates.
Personalized recommendation via cross-domain triadic factorization (2013)

Collaborative filtering (CF) is a major technique in recommender systems to help users find their potentially desired items. Since the data sparsity problem is quite commonly encountered in real-world scenarios, Cross-Domain Collaborative Filtering (CDCF) hence is becoming an emerging research topic in recent years. However, due to the lack of sufficient dense explicit feedbacks and even no feedback available in users' uninvolved domains, current CDCF approaches may not perform satisfactorily in user preference prediction. In this paper, we propose a generalized Cross Domain Triadic Factorization (CDTF) model over the triadic relation user-item-domain, which can better capture the interactions between domain-specific user factors and item factors. In particular, we devise two CDTF algorithms to leverage user explicit and implicit feedbacks respectively, along with a genetic algorithm based weight parameters tuning algorithm to trade off influence among domains optimally. Finally, we conduct experiments to evaluate our models and compare with other state-of-the-art models by using two real world datasets. The results show the superiority of our models against other comparative models.
The efficacy of isokinetic, isometric and vertical jump tests in exercise science. (1995)

This research examined the efficacy of several tests of muscular strength and power in their capacity to be related to performance, their ability to effectively discriminate between individuals of different performance levels and their sensitivity in detecting training induced changes to performance. Thirty healthy active subjects performed the following maximal tests of muscular function: (1) Vertical jump; (2) Isokinetic knee extension at 1.05, 3.14 and 5.24 rads s-1; and (3) Isometric rate of force development. Performance was assessed by the peak power output achieved on a cycle test. In addition, subjects participated in a 10 week resistance training program. The isokinetic and vertical jump tests were significantly related to performance (r = 0.5-0.73) and could be used to discriminate between subjects of differing performance levels. However, the isometric rate of force development test was an ineffective assessment modality. None of the tests were able to effectively monitor training induced changes in performance, as evidenced by non-significant correlations between the pre- to post-percentage changes in cycling performance and the test variables. Consequently, alterations to training programs for athletes should be based on changes in actual performance, as opposed to muscular function tests.
A gene‐cloning system for <i>Kluyveromyces lactis</i> and isolation of a chromosomal gene required for killer toxin production (1988)

A transformation system derived from the circular plasmid pKD1 has been developed for Kluyveromyces lactis. The principle is essentially equivalent to that of the 2 microns/Saccharomyces cerevisiae transformation system. The main features of the system are presented. Using a pKD1-based DNA bank of K. lactis, the KEX1 gene involved in the killer system was isolated by complementation.
Time-Domain Wavelength Interleaved Networking with Wavelength Reuse (2006)

Time-domain Wavelength Interleaved Networking (TWIN) is a cost-effective network architecture that can provide fine-grained, flexible connectivity using passive optics in internal nodes. Each wavelength is dedicated to carry traffic to a single node. We introduce TWIN with wavelength reuse (TWIN-WR), an extension of TWIN that allows the number of nodes to exceed the number of wavelengths. We formulate an associated design problem, decompose it into subproblems, and provide algorithms for solving the subproblems. We experimentally demonstrate that our algorithms come close to upper bounds over a wide range of parameters, and show that the resulting designs are robust in the face of traffic variability and uncertainty. Analysis and experiment show that high efficiency can be maintained as long as the number of nodes does not exceed the square of the number of wavelengths, in principle allowing a network with thousands of nodes using only one hundred wavelengths.
Influence of Systemic Fungicide on the Hematology of Silkworm Bombyx mori L. Infected with Beauveria bassiana (2003)

Systemic fungicides viz., Bavistin and Beyleton are reported to have curative effect against the infection of Beauveria bassiana in silkworm Bombyx mori L. To understand the influence of the systemic fungicides on the disease suppression/development, hematological studies were carried out. There was an increase in the percent total hemocyte count, granulocyte and plasmatocyte in silkworm treated with the systemic fungicides. It possibly indicates the influence of systemic fungicide on the hemocyte mediated defense system leading to the higher resistance and suppression of disease development.
Lateral migration and focusing of microspheres in a microchannel flow of viscoelastic fluids (2014)

The lateral migration of microspheres across streamlines induced by elasticity and inertia in a square microchannel flow of viscoelastic fluids is investigated using a holographic microscopy technique. We experimentally demonstrate the exact particle positions driven by the elasticity of fluid in the channel cross-section. The effects of the blockage ratio, flow rate, and shear-thinning property of the viscoelastic fluids on particle migration are evaluated. In particular, the focusing patterns of microspheres in three-dimensional volume are analyzed under different conditions, namely, dominant inertia, dominant elasticity, and the combined effects of inertia and elasticity.
A CSMA/CA MAC Protocol for Multi-User MIMO Wireless LANs (2010)

Multiple-input multiple-output (MIMO) is one form of the smart antenna technology that uses multiple antennas at both the transmitter and receiver to improve communication performance. In this paper, we investigate the problem of medium access control in wireless local area networks (WLANs) with downlink multi-user MIMO (DL MU MIMO) capability. We propose a CSMA/CA MAC protocol with three response mechanisms for DL MU MIMO and compare the performance of DL MU MIMO with the beam-forming (BF) based approach. A novel per-station weighted queuing mechanism is proposed to mitigate the hidden node problem in the network. Performance analysis and simulation study both show that the proposed DL MU MIMO mechanism incurs low overhead and provides significant throughput performance gain over BF based approach in high SNR scenarios.