gebhart/patrepeval huggingface dataset:
Use of functional status measures for payment of medical rehabilitation services. (1992)

In the search for an appropriate payment system for medical rehabilitation hospitals and units, the use of a functional status measure (FSM) has emerged as a recurring theme. Conceptually, functional status measurement is important because the primary goal of medical rehabilitation is to enhance patient function and independence. Studies indicate that functional status and functional gain are among the best predictors of resource utilization at rehabilitation facilities. This article examines conceptually the use of FSMs in payment for medical rehabilitation in two different types of payment systems--as a means of classifying patients for purposes of determining the applicable payment amount (ie, a "classification system"), and as a means of justifying that payment, or continued payment, for services is appropriate (ie, a "justification system"). Several payment models using an FSM are described and analyzed. An agenda for future research is proposed.
Enhancement of Borna Disease Virus Transcription in Persistently Infected Cells by Serum Starvation. (1999)

Transcription of Borna disease virus (BDV) in persistently infected MDCK (MDCK/BDV) cells increased in the fetal bovine serum free media as detected by Northern blot analysis. Especially, the amount of 1.9-kb RNA without cap formation at the 5' end and polyadenylation at the 3' end, increased as compared to other mRNA molecules of BDV. Growth arrest of MDCK/BDV cells observed in the condition of serum starvation might be important for increasing viral transcription. Since N-cadherin is the responsible factor for cell-to-cell contact, MDCK/BDV cells were cultured in calcium free medium which inhibits the interaction of N-cadherin. However, inhibition of cell-to-cell contact by N-cadherin is not effective on up regulation of viral transcription. Our finding in this study indicates that enhancement of BDV transcription by serum starvation is a useful technique for further investigation in understanding of mechanisms of BDV transcription.
The Copper-Catalyzed Addition of Arenesulfonyl Chlorides to 1,1-Diphenylthylene and Cyclic Aryl-Substituted Olefins (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Copper-Catalyzed Addition of Arenesulfonyl Chlorides to 1,1-Diphenylthylene and Cyclic Aryl-Substituted OlefinsWilliam Truce and Christian GoralskiCite this: J. Org. Chem. 1970, 35, 12, 4220–4222Publication Date (Print):December 1, 1970Publication History Published online13 August 2002Published inissue 1 December 1970https://pubs.acs.org/doi/10.1021/jo00837a613https://doi.org/10.1021/jo00837a613research-articleACS PublicationsRequest reuse permissionsArticle Views138Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene (1992)

Pleiotrophin (PTN), midkine (MK), and retinoic acid-induced heparin-binding (RI-HB) protein are members of a recently discovered family of developmentally regulated cytokines. We report here the cloning, sequencing, chromosomal localization, and structural organization of the genomic version of the human PTN gene and its comparison to the mouse MK gene. The PTN gene was found to be arranged in five exons and four introns, in a fashion similar to that of the mouse MK gene. Exon 1, as for MK, does not appear to encode amino acid sequence. As in the case of the MK gene, exon 2 encodes the hydrophobic leader sequence of PTN, which constitutes the beginning of gene translation. The signal peptide cleavage site of both genes lies toward the 3' end of exon 2. Exons 3 and 4 of PTN were most closely related to exons 3 and 4 of the MK gene; in particular, six of the ten cysteine residues were coded for in exon 3 and the remaining 4 in exon 4. The intron-exon splice junctions of both genes occurred through the same residues. The two genes were found to be less closely related in the fifth exon which encodes the highly basic C-terminal domains, the translation termination codon, and the polyadenylation signal of both cDNAs. We also report approximately 2000 bp of the 5' untranslated sequence of the PTN gene and the site of initiation of transcription in human placenta. PTN was localized to human chromosome 7q33-34 by fluorescence in situ hybridization. These data confirm the existence of a new gene family of developmentally regulated cytokines.
476. A conversion of cholest-4-en-3-one into cholesterol (1950)

A. J. Birch, J. Chem. Soc., 1950, 2325 DOI: 10.1039/JR9500002325
Novel antibiotics, amythiamicins. I. Taxonomy, fermentation, isolation, physico-chemical properties, and antimicrobial activity. (1994)

Novel antibacterial antibiotics, amythiamicins A, B, C and D, have been isolated from the fermentation broth of Amycolatopsis sp. MI481-42F4. In this paper, the taxonomy of the producing strain, fermentation, isolation, physico-chemical properties and biological activities of amythiamicins are reported. Amythiamicins inhibit the growth of Gram-positive bacteria including multi-drug resistant strains.
Structure of Corn Hull Hemicellulose. Part III. Identification of the Methylated Aldobiouronic Acid Obtained from Methyl Corn Hull Hemicellulose<sup>1,2</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of Corn Hull Hemicellulose. Part III. Identification of the Methylated Aldobiouronic Acid Obtained from Methyl Corn Hull Hemicellulose1,2R. Montgomery and F. SmithCite this: J. Am. Chem. Soc. 1957, 79, 3, 695–697Publication Date (Print):February 1, 1957Publication History Published online1 May 2002Published inissue 1 February 1957https://pubs.acs.org/doi/10.1021/ja01560a052https://doi.org/10.1021/ja01560a052research-articleACS PublicationsRequest reuse permissionsArticle Views142Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Normally-off high-voltage p-GaN gate GaN HFET with carbon-doped buffer (2011)

Normally-off GaN transistors for power applications in p-type GaN gate technology with a modified carbon-doped GaN buffer are presented. A combination of an AlGaN back-barrier with the carbon-doped buffer prevents early off-state punch-through. Simultaneously, the on-state resistance could be kept low and the threshold voltage with 1.1 V high enough for secure normally-off operation. 1000 V breakdown strength has been obtained for devices with 6 μm gate-drain spacing. The resulting breakdown scaling slope is 170 V/μm gate-drain distance. The on-state resistance is 7.4 Ωmm. The resulting V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Br</sub> -to-R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> A ratio (1000 V, 0.62 mΩcm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) is beyond so far reported ratios for normally-off GaN transistors. Modifications of the p-type GaN layer have shown to additionally increase the threshold voltage by 0.4 V without paying a price in the on-state resistance of the device.
Fruit and vegetables and cancer risk (2010)

The possibility that fruit and vegetables may help to reduce the risk of cancer has been studied for over 30 years, but no protective effects have been firmly established. For cancers of the upper gastrointestinal tract, epidemiological studies have generally observed that people with a relatively high intake of fruit and vegetables have a moderately reduced risk, but these observations must be interpreted cautiously because of potential confounding by smoking and alcohol. For lung cancer, recent large prospective analyses with detailed adjustment for smoking have not shown a convincing association between fruit and vegetable intake and reduced risk. For other common cancers, including colorectal, breast and prostate cancer, epidemiological studies suggest little or no association between total fruit and vegetable consumption and risk. It is still possible that there are benefits to be identified: there could be benefits in populations with low average intakes of fruit and vegetables, such that those eating moderate amounts have a lower cancer risk than those eating very low amounts, and there could also be effects of particular nutrients in certain fruits and vegetables, as fruit and vegetables have very varied composition. Nutritional principles indicate that healthy diets should include at least moderate amounts of fruit and vegetables, but the available data suggest that general increases in fruit and vegetable intake would not have much effect on cancer rates, at least in well-nourished populations. Current advice in relation to diet and cancer should include the recommendation to consume adequate amounts of fruit and vegetables, but should put most emphasis on the well-established adverse effects of obesity and high alcohol intakes.
Enhancing the Thermoelectric Properties of Germanium Antimony Tellurides by Substitution with Selenium in Compounds Ge<sub><i>n</i></sub>Sb<sub>2</sub>(Te<sub>1–<i>x</i></sub>Se<sub><i>x</i></sub>)<sub><i>n</i>+3</sub> (0 ≤ <i>x</i> ≤ 0.5; <i>n</i> ≥ 7) (2014)

Quenched pseudocubic germanium antimony tellurides (GST compounds) exhibit promising thermoelectric properties. These are related to the nanostructures which can be influenced by varying the composition and the thermal treatment. The substitution of Te by Se in bulk samples of GenSb2Ten+3 with high thermoelectric figures of merit (ZT) is possible over a wide compositional range. This results in solid solution series GenSb2(Te1–xSex)n+3 with 0 < x < 0.75 for n ≥ 7. Se substitution reduces the average lateral extension of the defect layers in quenched samples. This is a consequence of the reduced mobility during the quenching process due to the lower cubic to trigonal phase transition temperatures of Se-substituted samples. Most pronounced for n = 7, Se doping increases the transition temperatures between the nanostructured (pseudo)cubic modification of quenched samples and their layered trigonal phase. This increases the temperature ranges in which the materials can be employed without altering their nanostructures and properties. When Se is introduced, the Seebeck coefficient increases and the thermal conductivity decreases. The ZT value of Ge7Sb2Te8Se2, for instance, increases up to 1.2 at 425 °C, which is 6 times higher than that of Ge7Sb2Te10. Similarly, the ZT value of Ge12Sb2(Te1–xSex)15 increases up to a factor of 2 for x = 0.2 at temperatures below 400 °C. The most promising thermoelectric properties (ZT = 1.2 at 425 °C for n = 7 and ZT = 1.1 at 350 °C for n = 12) are observed for x = 0.2 whereas higher Se substitution rates result in a less pronounced effect. The average structures were determined by powder as well as single crystal X-ray diffraction (SCXRD). The real structure of quenched GenSb2(Te1–xSex)n+3 (0 ≤ x ≤ 0.5; n ≥ 7) bulk material was investigated by high-resolution electron microscopy (HRTEM) with respect to the degree of substitution (x) and correlated with the resulting changes of the thermoelectric properties. The decrease of the lateral extension of the defect layers with increasing Se content as found by HRTEM and electron diffraction is confirmed by SCXRD data for Ge∼5Sb2(Te0.13Se0.87)∼8.
Immunotyping of Human Immunodeficiency Virus Type 1 (HIV): an Approach to Immunologic Classification of HIV (1999)

Because immunologic classification of human immunodeficiency virus type 1 (HIV) might be more relevant than genotypic classification for designing polyvalent vaccines, studies were undertaken to determine whether immunologically defined groups of HIV ("immunotypes") could be identified. For these experiments, the V3 region of the 120-kDa envelope glycoprotein (gp120) was chosen for study. Although antibodies (Abs) to V3 may not play a major protective role in preventing HIV infection, identification of a limited number of immunologically defined structures in this extremely variable region would set a precedent supporting the hypothesis that, despite its diversity, the HIV family, like the V3 region, might be divisible into immunotypes. Consequently, the immunochemical reactivities of 1,176 combinations of human anti-V3 monoclonal Abs (MAbs) and V3 peptides, derived from viruses of several clades, were studied. Extensive cross-clade reactivity was observed. The patterns of reactivities of 21 MAbs with 50 peptides from clades A through H were then analyzed by a multivariate statistical technique. To test the validity of the mathematical approach, a cluster analysis of the 21 MAbs was performed. Five groups were identified, and these MAb clusters corresponded to classifications of these same MAbs based on the epitopes which they recognize. The concordance between the MAb clusters identified by mathematical analysis and by their specificities supports the validity of the mathematical approach. Therefore, the same mathematical technique was used to identify clusters within the 50 peptides. Seven groups of peptides, each containing peptides from more than one clade, were defined. Inspection of the amino acid sequences of the peptides in each of the mathematically defined peptide clusters revealed unique "signature sequences" that suggest structural motifs characteristic of each V3-based immunotype. The results suggest that cluster analysis of immunologic data can define immunotypes of HIV. These immunotypes are distinct from genotypic classifications. The methods described pave the way for identification of immunotypes defined by immunochemical and neutralization data generated with anti-HIV Env MAbs and intact, viable HIV virions.
A Method for Extracting an Object by Segmentation Based on General Information between Regions. (2001)

We propose a method for segmenting a color image and extracting a region of an object in a scene by using information which is not specific to the target object but common to a projection of the object in a space. The proposed method is based on a split-and-merge technique. The image is initially segmented into small regions by clustering in color space. Then the regions are merged based on four features of information on the configuration, connection and area ratio of adjacent pairs of regions. This merging allows us to extract an object as a single region even if the surface of the object is textured with a variety of reflectances; this isn't considered by conventional segmentation methods. We give our algorithm for segmentation and extraction, demonstrate experimental results, and make comparisons with some other methods.
Cell cycle-dependent transcription from the gid and mioC promoters of Escherichia coli (1994)

Transcription from the gid and mioC promoters, which neighbor the origin of replication of the Escherichia coli chromosome (oriC), has been implicated in the control of initiation of replication of minichromosomes. The amounts of transcripts from these two promoters on the chromosome were quantified at various times in a synchronized culture of a temperature-sensitive dnaC mutant strain. Transcription from the gid promoter was most active before the initiation of replication and was inhibited after initiation, during the time corresponding to the period of sequestration of the oriC region from the dam methyltransferase. On the other hand, transcription from the mioC promoter was inhibited before initiation and the inhibition was relieved after initiation prior to the recovery of gid transcription. The strict regulation of transcription from the gid and mioC promoters may be involved in positive and negative control of chromosomal replication, respectively, as has been suggested for minichromosome replication. The DnaA protein was involved in repression of mioC transcription, indicating that the activity of the DnaA protein changes during the cell cycle.
Image scanning microscopy with a quadrant detector (2015)

Confocal scanning microscopy (CSM) is the most widely used modern optical microscopy technique. Theoretically, it allows the diffraction barrier to be surpassed by a factor of 2, but practically this improvement is sacrificed to obtain a good signal-to-noise ratio (SNR). Image scanning microscopy (ISM) solves this limitation but, in the current implementations, the system complexity is increased and the versatility of CSM is reduced. Here we show that ISM can be straightforwardly implemented by substituting the single point detector of a confocal microscope with a quadrant detector of the same size, thus using a small number of detector elements. This implementation offers resolution close to the CSM theoretical value and improves the SNR by a factor of 1.5 with respect to the CSM counterpart without losing the optical sectioning capability and the system versatility.
Distinct Pathways for Stimulation of Cytochrome cRelease by Etoposide (2000)

Induction of apoptosis by DNA-damaging agents, such as etoposide, is known to involve the release of mitochondrial cytochrome c, although the mechanism responsible for this event is unclear. In the present study, using Jurkat T-lymphocytes, a reconstituted cell-free system, or isolated liver mitochondria, we demonstrate the ability of etoposide to induce cytochrome c release via two distinct pathways. Caspase inhibition by either benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (z-VAD-fmk) or benzyloxycarbonyl-Val-Asp-Val-Ala-Asp-fluoromethyl ketone (z-VDVAD-fmk) attenuates cytochrome c release triggered by a low dose of etoposide via an apparent inhibition of nuclear events involving the release of protein factor(s) that is (are) able to interact with mitochondria. In contrast, caspase inhibition has no effect on cytochrome c release induced by a higher dose of etoposide. Moreover, the higher dose of etoposide heightens the sensitivity of Ca(2+)-loaded isolated mitochondria to mitochondrial permeability transition, an effect that is completely abolished by cyclosporin A. Interestingly, cyclosporin A is ineffective at preventing similar mitochondrial damage in Jurkat cells treated with etoposide. We propose that lower doses of etoposide predominantly target the nucleus and stimulate the release of caspase-sensitive protein factor(s) that interact with mitochondria to trigger cytochrome c release, whereas higher doses of the drug impart a more direct effect on mitochondria and thus are not mitigated by caspase inhibition.
Dual Specificity and Novel Structural Folding of Yeast Phosphodiesterase-1 for Hydrolysis of Second Messengers Cyclic Adenosine and Guanosine 3′,5′-Monophosphate (2014)

Cyclic nucleotide phosphodiesterases (PDEs) decompose second messengers cAMP and cGMP that play critical roles in many physiological processes. PDE1 of Saccharomyces cerevisiae has been subcloned and expressed in Escherichia coli. Recombinant yPDE1 has a KM of 110 μM and a kcat of 16.9 s(-1) for cAMP and a KM of 105 μM and a kcat of 11.8 s(-1) for cGMP. Thus, the specificity constant (kcat/KM(cAMP))/(kcat/KM(cGMP)) of 1.4 indicates a dual specificity of yPDE1 for hydrolysis of both cAMP and cGMP. The crystal structures of unliganded yPDE1 and its complex with GMP at 1.31 Å resolution reveal a new structural folding that is different from those of human PDEs but is partially similar to that of some other metalloenzymes such as metallo-β-lactamase. In spite of their different structures and divalent metals, yPDE1 and human PDEs may share a common mechanism for hydrolysis of cAMP and cGMP.
Solid-state image sensors (1991)

This tutorial reviews the basic concepts and the progress in the field of visible and infrared image sensors. The topics to be reviewed include: photodetectors and readout structures, architectures for line and area sensing arrays, structures and techniques for controlling blooming and smear, noise sources and tile figures of merit for visible and infrared imagers. This presentation will also be complemented by an overview and illustrations of the state-of-the-art of visible and infrared image sensors with a major emphasis on silicon VLSI sensors for HDTV and infrared imaging with Schottky-barrier detectors. The performance of the visible and infrared imagesensors will also be illustrated with a video tape presentation.
ChemInform Abstract: Solid‐State NMR in Japan (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Notizen Asymmetric Syntheses <i>via</i> Heterocyclic Intermediates, XXIV. Enantioselective Synthesis of (<i>R</i>)‐α‐Methyltryptophane Methyl Ester and D‐Tryptophane Methyl Ester by the Bislactim Ether Route (1985)

Asymmetrische Synthesen über heterocyclische Zwischenstufen, XXIV 1) . – Enantioselektive Synthese von ( R )‐α‐Methyltryptophan‐methylester und D‐Tryptophan‐methylester nach der Bislactimether‐Methode Die Titelverbindungen wurden durch asymmetrische Synthese nach der Bislactimether‐Methode hergestellt (e.e. über 95% bzw. etwa 90%).
Amplified phase conjugate reflection of KrF laser radiation (1981)

We report amplified phase conjugate reflection of KrF laser radiation at 249 nm using degenerate four-wave mixing in a solution of rhodamine 6G in ethanol. Reflectivities of ∼300% have been measured. Saturation of the reflectivity at high probe intensities was observed and the temporal dependence of the reflectivity has been investigated. The importance of mutual coherence of the probe and pump for the thermally induced nonlinearity involved in the process has been demonstrated.