gebhart/patrepeval huggingface dataset:
Synthesis and Antimicrobial Activity of Some Alkyl 3-Phenanthridinols (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Antimicrobial Activity of Some Alkyl 3-PhenanthridinolsCHARLES K. BRADSHER, FRANCES C. BROWN, and PRESTON H. LEAKECite this: J. Org. Chem. 1957, 22, 5, 500–502Publication Date (Print):May 1, 1957Publication History Published online1 May 2002Published inissue 1 May 1957https://pubs.acs.org/doi/10.1021/jo01356a006https://doi.org/10.1021/jo01356a006research-articleACS PublicationsRequest reuse permissionsArticle Views159Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Report from a WHO working group: standard method for detecting upper respiratory carriage of Streptococcus pneumoniae (2003)

The Core Consensus Methods provide a common methodology to conduct pneumococcal NP colonization studies with minimum interstudy method variability. The intention is to allow more meaningful comparisons of study results from conjugate pneumococcal vaccine trials.
Rateless packet approach for data gathering in wireless sensor networks (2010)

In this paper, we propose a novel approach for data gathering in wireless sensor networks (WSN) based on distributed rateless codes. Rateless codes are an efficient, lowcomplexity solution for coded data transmission over channels with packet erasures, which motivates their application in distributed network scenarios such as WSN. Recently proposed distributed rateless coding techniques for WSN are node-centric, i.e., collecting sufficient number of different sensor data packets and performing rateless encoding is the task of sensor nodes. In the proposed packet-centric approach, this task is assigned to encoded packets called rateless packets. While randomly moving through the network, rateless packets collect and encode into their content required number of uniformly sampled sensor data packets, completing their paths in randomly selected network nodes. Using this approach, any degree distribution of rateless codes can be exactly obtained. The problem of uniform combining of sensor data into rateless packets, and uniform dispersion throughout the network is addressed. The efficiency of the proposed scheme and comparison with the performance of centralized rateless codes are demonstrated by simulation results.
Directing Zeolite Structures into Hierarchically Nanoporous Architectures (2011)

Crystalline mesoporous molecular sieves have long been sought as solid acid catalysts for organic reactions involving large molecules. We synthesized a series of mesoporous molecular sieves that possess crystalline microporous walls with zeolitelike frameworks, extending the application of zeolites to the mesoporous range of 2 to 50 nanometers. Hexagonally ordered or disordered mesopores are generated by surfactant aggregates, whereas multiple cationic moieties in the surfactant head groups direct the crystallization of microporous aluminosilicate frameworks. The wall thicknesses, framework topologies, and mesopore sizes can be controlled with different surfactants. The molecular sieves are highly active as catalysts for various acid-catalyzed reactions of bulky molecular substrates, compared with conventional zeolites and ordered mesoporous amorphous materials.
Diffusion, dispersion, and settling of hard spheres (1992)

Using a multiple light scattering technique and a stabilizing counterflow (i.e., a fluidized bed), we measured the average sedimentation velocity, its variance, and the short-time self-diffusion coefficient in a concentrated hard-sphere suspension. Many-body hydrodynamic interactions slow both the Brownian diffusion and mean sedimentation and provide a novel mechanism for long time dispersion.
Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA (2015)

Chimeric antigen receptor T cell immunotherapy is a promising therapeutic strategy for treating tumors, demonstrating its efficiency in eliminating several hematological malignancies in recent years. However, a major obstacle associated with current chimeric antigen receptor T cell immunotherapy is that the limited replicative lifespan of chimeric antigen receptor T cells prohibits the long-term persistence and expansion of these cells in vivo, potentially hindering the long-term therapeutic effects of chimeric antigen receptor T cell immunotherapy. Here we showed that the transient delivery of modified mRNA encoding telomerase reverse transcriptase to human chimeric antigen receptor T cells targeting the CD19 antigen (CD19 chimeric antigen receptor T cells) would transiently elevate the telomerase activity in these cells, leading to increased proliferation and delayed replicative senescence without risk of insertion mutagenesis or immortalization. Importantly, compared to conventional CD19 chimeric antigen receptor T cells, after the transient delivery of telomerase reverse transcriptase mRNA, these CD19 chimeric antigen receptor T cells showed improved persistence and proliferation in mouse xenograft tumor models of human B-cell malignancies. Furthermore, the transfer of CD19 chimeric antigen receptor T cells after the transient delivery of telomerase reverse transcriptase mRNA enhanced long-term antitumor effects in mouse xenograft tumor models compared with conventional CD19 chimeric antigen receptor T cell transfer. The results of the present study provide an effective and safe method to improve the therapeutic potential of chimeric antigen receptor T cells, which might be beneficial for treating other types of cancer, particularly solid tumors.
Comparing Collision Threat Measures for Verification of Autonomous Vehicles using Extreme Value Theory (2016)

The verification of safety is expected to be one of the largest challenges in the commercialization of autonomous vehicles. Using traditional methods would require infeasible time and resources. Recent research has shown the possibility of using near-collisions in order to estimate the frequency of actual collisions using Extreme Value Theory. However, little research has been done on how the measure for determining the closeness to a collision affect the result of the estimation. This paper compares a collision-based measure against one that relates to an inevitable collision state. The result shows that using inevitable collision states is more robust and that more research needs to be made into measures of collision proximity.
Thermal grafting of fluorinated molecular monolayers on doped amorphous silicon surfaces (2009)

Thermally induced (160–300 °C) gas phase grafting of linear alkene molecules (perfluorodecene) was performed on hydrogenated amorphous silicon (a-Si:H) films, either nominally undoped or doped with different boron and phosphorus concentrations. Dense and smooth a-Si:H films were grown using plasma decomposition of silane. Quantitative analysis of in situ x-ray photoelectron spectroscopy indicates the grafting of a single layer of organic molecules. The hydrophobic properties of perfluorodecene-modified surfaces were studied as a function of surface coverage. Annealing experiments in ultrahigh vacuum show the covalent binding and the thermal stability of these immobilized layers up to 370 °C; this temperature corresponds to the Si–C bond cleavage temperature. In contrast with hydrogenated crystalline Si(111):H, no heavy wet chemistry surface preparation is required for thermal grafting of alkene molecules on a-Si:H films. A threshold grafting temperature is observed, with a strong dependence on the doping level which produces a large contrast in the molecular coverage for grafting performed at 230 °C.
Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis (2014)

Our findings are the first to demonstrate that therapeutic intervention with a HIF hydroxylase inhibitor ameliorates IBD in disease models. These findings highlight the potential of TRC160334 for its clinical application in the treatment of IBD.
LEXICALL: Lexicon Construction for Foreign Language Tutoring (1997)

We focus on the problem of building large repositories of lexical conceptual structure (LCS) representations for verbs in multiple languages.One of the main results of this work is the de nition of a relation between broad semantic classes and LCS meaning components.Our acquisition program|LEXICALL|takes, as input, the result of previous work on verb classi cation and thematic grid tagging, and outputs LCS representations for di erent languages.These representations have been ported into English, Arabic and Spanish lexicons, each containing approximately 9000 verbs.We are currently using these lexicons in an operational foreign language tutoring and machine translation.
Determination of the active and inactive metabolites of prasugrel in human plasma by liquid chromatography/tandem mass spectrometry (2006)

Two fast and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS)-based bioanalytical assays were developed and validated to quantify the active and three inactive metabolites of prasugrel. Prasugrel is a novel thienopyridine prodrug that is metabolized to the pharmacologically active metabolite in addition to three inactive metabolites, which directly relate to the formation and elimination of the active metabolite. After extraction and separation, the analytes were detected and quantified using a triple quadrupole mass spectrometer using positive electrospray ionization. The validated concentration range for the inactive metabolites assay was from 1 to 500 ng/mL for each of the three analytes. Additionally, a 5x dilution factor was validated. The interday accuracy ranged from -10.5% to 12.5% and the precision ranged from 2.4% to 6.6% for all three analytes. All results showed accuracy and precision within +/-20% at the lower limit of quantification and +/-15% at other levels. The validated concentration range for the active metabolite assay was from 0.5 to 250 ng/mL. Additionally, a 10x dilution factor was validated. The interbatch accuracy ranged from -7.00% to 5.98%, while the precision ranged from 0.98% to 3.39%. Derivatization of the active metabolite in blood with 2-bromo-3'-methoxyacetophenone immediately after collection was essential to ensure the stability of the metabolite during sample processing and storage. These methods have been applied to determine the concentrations of the active and inactive metabolites of prasugrel in human plasma.
Oral Health: The Need for Both Conventional Microbial and Molecular Characterization (2017)

This study aims to consider the microbial distribution in oral disease, as well as gene analysis and expression, in elucidating: 1, the fundamental underpinnings of oral disease, and 2, the potential relationship between oral diseases and systemic health.A key focus is identifying the microbiota associated with oral disease manifestations characterized by both conventional microbiological and molecular methods.Variations in the observed microbial populations characterized by conventional and molecular approaches have been identified for caries, periodontitis, peri-implantitis, and stomatitis.The discovery of therapeutic approaches for oral disease will require comprehensive microbial and genomic analysis.This study evaluated the current state of the relevant microbial and genomic information for several prevalent oral diseases.
Integrated automotive sensors (2002)

Focuses on automotive applications and discusses the development of a suite of integrated radar and IR sensors that can be used to surround a vehicle (car, truck, boat, etc.). The primary function is to provide information to the vehicle systems and operator as enhancements to passenger and vehicle safety. It may also provide vehicle information (speed, location, destination, etc.) and integrate information (weather, road/traffic conditions, service/rest-area location, route details, etc.) from an intelligent vehicle highway system.
March 7, 1871 (1871)

But I see 110 reason to cliaiige my fornicr deteriniliation.The figure in the ' IIistoire Naturelle clcs AInnimifhes,' altliougli stated to have beeii taken from a drawiug", agrees in nearly every respect with our specimen.In ,4ugust last Mr. W. .Tamrach deposited in tlie Society's Gardens three Monkeys of this species, aloiig with two of M .ocreatzrs aiid six of the so-called Cynopithecus niger.On tlie 1st of January of the preseut year we purchased two of these animals, which are still living in the Gardens.It is unfortunate that we do not yet with certainty know the exact locality of this Macaque.But I thiiik it,is probably Boriieo, as already conjectured by Dr. Gray.This Macaque is of exactly the saine form as 31.ocwutus (figured P. z. S. 18G0, Mamm.pl.Ixxxii.) ; and thc youug aninials of the two species are so much alike, that oiie of RIr.Jamrach's specimens, supposed when it was deposited to be 171.muums, lias since turiied out to be &I.ocreatzis.4. ATCLES GRISCSCENS, Gray, P. Z. S. 1865, p. 732; Cat. of Monkeys, p. 43.Dr. Gray founded this species of dfeles upoii a specimen that was living in our Gardens iii 1864.It was brought home by hlr.E. Greey, F.Z.S. (who was
Construction of supported fission foils for laser excitation (1977)

A procedure is described for making smooth, durable coatings of uranium oxide (∼5 μm thick) on ceramic substrates such as alumina and beryllia. The coatings have shown no damage after being excited repeatedly to ∼1020 fissions/m3 with a thermal neutron pulse ∼150 μsec wide. The uniformity of fission fragment energy emission from the coatings has been measured and the coating structure has been studied with electron microscopy.
Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a<i>Borrelia burgdorferi</i>peptide (2006)

An association has previously been shown between antibiotic-refractory Lyme arthritis, the human histocompatibility leukocyte antigen (HLA)-DR4 molecule, and T cell recognition of an epitope of Borrelia burgdorferi outer-surface protein A (OspA163-175). We studied the frequencies of HLA-DRB1-DQA1-DQB1 haplotypes in 121 patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis and correlated these frequencies with in vitro binding of the OspA163-175 peptide to 14 DRB molecules. Among the 121 patients, the frequencies of HLA-DRB1-DQA1-DQB1 haplotypes were similar to those in control subjects. However, when stratified by antibiotic response, the frequencies of DRB1 alleles in the 71 patients with antibiotic-refractory arthritis differed significantly from those in the 50 antibiotic-responsive patients (log likelihood test, P = 0.006; exact test, P = 0.008; effect size, Wn = 0.38). 7 of the 14 DRB molecules (DRB1*0401, 0101, 0404, 0405, DRB5*0101, DRB1*0402, and 0102) showed strong to weak binding of OspA163-175, whereas the other seven showed negligible or no binding of the peptide. Altogether, 79% of the antibiotic-refractory patients had at least one of the seven known OspA peptide-binding DR molecules compared with 46% of the antibiotic-responsive patients (odds ratio = 4.4; P < 0.001). We conclude that binding of a single spirochetal peptide to certain DRB molecules is a marker for antibiotic-refractory Lyme arthritis and might play a role in the pathogenesis of the disease.
<i>Neisseria bacilliformis</i> sp. nov. Isolated from Human Infections (2006)

Most Neisseria species are gram-negative cocci or diplococci; currently, N. elongata is the only species of human origin with a bacillary morphology. Here, we report isolation and characterization of eight strains of another bacillary Neisseria species from human infections. The organisms caused or contributed to either oral cavity-related or respiratory tract infections, and two strains were isolated from blood cultures. The 16S rRNA gene sequences of these organisms, being homogenous or nearly so (99.4 to 100% identity), matched at <96% known Neisseria species and formed a distinct group within the genus. Analysis of the cellular fatty acids showed broad similarity with a few Neisseria species. The organisms were gram negative and measured 0.6 mum by 1.3 to 3.0 mum. They grew well on chocolate agar and on sheep blood agar but did not grow on modified Thayer-Martin agar. They were positive for oxidase and negative for indole production. There was no acid production from dextrose, lactose, maltose, or sucrose. The tests for catalase reaction, nitrate reduction, and tributilin varied with the strains. These results suggest that these organisms represent a novel species within the genus Neisseria, for which the name Neisseria bacilliformis sp. nov. is proposed. The type strain is MDA2833 = ATCC BAA-1200(T) = CCUG50858(T). Distinction between N. bacilliformis and N. elongata can be made confidently by 16S rRNA gene sequencing or cellular fatty acid profiling but may be difficult by morphology or routine biochemical tests.
RFID Technology for Management and Tracking: e-Health Applications (2018)

Radio frequency identification (RFID) has become a key technology in the logistics and management industry, thanks to distinctive features such as the low cost of RFID tags, and the easiness of the RFID tags' deployment and integration within the items to be tracked. In consequence, RFID plays a fundamental role in the so-called digital factory or 4.0 Industry, aiming to increase the level of automatization of industrial processes. In addition, RFID has also been found to be of great help in improving the tracking of patients, medicines, and medical assets in hospitals, where the digitalization of these operations improves their efficiency and safety. This contribution reviews the state-of-the-art of RFID for e-Health applications, describing the contributions to improve medical services and discussing the limitations. In particular, it has been found that a lot of effort has been put into software development, but in most of the cases a detailed study of the physical layer (that is, the characterization of the RFID signals within the area where the system is deployed) is not properly conducted. This contribution describes a basic RFID system for tracking and managing assets in hospitals, aiming to provide additional details about implementation aspects that must be considered to ensure proper functionality of the system. Although the scope of the RFID system described in this contribution is restricted to a small area of the hospital, the architecture is fully scalable to cover the needs of the different medical services in the hospital. Ultra high-frequency (UHF) RFID technology is selected over the most extended near-field communication (NFC) and high-frequency (HF) RFID technology to minimize hardware infrastructure. In particular, UHF RFID also makes the coverage/reading area conformation easier by using different kinds of antennas. Information is stored in a database, which is accessed from end-user mobile devices (tablets, smartphones) where the position and status of the assets to be tracked are displayed.
Three-dimensional multi-resolution statistical reconstruction for tomosynthesis (2005)

In this paper, we propose a novel three-dimensional maximum a posteriori (MAP) algorithm for tomosynthetic reconstruction. The motivation of this work is to improve the image quality while simultaneously reduce the computational cost that is the most challenging problem of the statistical (Bayesian) reconstruction algorithm. The proposed method utilizes a multi-resolution representation for both reconstruction and projections. The imaged object is reconstructed from the coarsest scale to the finest scale, sequentially. Simulations are presented showing that the proposed algorithm produces better imaged-quality and leads to faster convergence than the alternative methods.
Flipping the Switch on Clathrin‐Mediated Endocytosis using Thermally Responsive Protein Microdomains (2014)

A ubiquitous approach to study protein function is to knock down activity (gene deletions, siRNA, small molecule inhibitors, etc) and study the cellular effects. Using a new methodology, this manuscript describes how to rapidly and specifically switch off cellular pathways using thermally responsive protein polymers. A small increase in temperature stimulates cytosolic elastin-like polypeptides (ELPs) to assemble microdomains. We hypothesize that ELPs fused to a key effector in a target macromolecular complex will sequester the complex within these microdomains, which will bring the pathway to a halt. To test this hypothesis, we fused ELPs to clathrin-light chain (CLC), a protein associated with clathrin-mediated endocytosis. Prior to thermal stimulation, the ELP fusion is soluble and clathrin-mediated endocytosis remains 'on.' Increasing the temperature induces the assembly of ELP fusion proteins into organelle-sized microdomains that switches clathrin-mediated endocytosis 'off.' These microdomains can be thermally activated and inactivated within minutes, are reversible, do not require exogenous chemical stimulation, and are specific for components trafficked within the clathrin-mediated endocytosis pathway. This temperature-triggered cell switch system represents a new platform for the temporal manipulation of trafficking mechanisms in normal and disease cell models and has applications for manipulating other intracellular pathways.
A Hydrogen Peroxide-Forming NADH Oxidase That Functions as an Alkyl Hydroperoxide Reductase in <i>Amphibacillus xylanus</i> (2000)

The Amphibacillus xylanus NADH oxidase, which catalyzes the reduction of oxygen to hydrogen peroxide with beta-NADH, can also reduce hydrogen peroxide to water in the presence of free flavin adenine dinucleotide (FAD) or the small disulfide-containing Salmonella enterica AhpC protein. The enzyme has two disulfide bonds, Cys128-Cys131 and Cys337-Cys340, which can act as redox centers in addition to the enzyme-bound FAD (K. Ohnishi, Y. Niimura, M. Hidaka, H. Masaki, H. Suzuki, T. Uozumi, and T. Nishino, J. Biol. Chem. 270:5812-5817, 1995). The NADH-FAD reductase activity was directly dependent on the FAD concentration, with a second-order rate constant of approximately 2.0 x 10(6) M(-1) s(-1). Rapid-reaction studies showed that the reduction of free flavin occurred through enzyme-bound FAD, which was reduced by NADH. The peroxidase activity of NADH oxidase in the presence of FAD resulted from reduction of peroxide by free FADH(2) reduced via enzyme-bound FAD. This peroxidase activity was markedly decreased in the presence of oxygen, since the free FADH(2) is easily oxidized by oxygen, indicating that this enzyme system is unlikely to be functional in aerobic growing cells. The A. xylanus ahpC gene was cloned and overexpressed in Escherichia coli. When the NADH oxidase was coupled with A. xylanus AhpC, the peroxidase activity was not inhibited by oxygen. The V(max) values for hydrogen peroxide and cumene hydroperoxide reduction were both approximately 150 s(-1). The K(m) values for hydrogen peroxide and cumene hydroperoxide were too low to allow accurate determination of their values. Both AhpC and NADH oxidase were induced under aerobic conditions, a clear indication that these proteins are involved in the removal of peroxides under aerobic growing conditions.