gebhart/patrepeval huggingface dataset:
Four new recurring translocations in non-Hodgkin lymphoma (1989)

The identification of recurring chromosomal translocations has provided clues to the gene regions important in lymphoma development. Among 157 patients with non-Hodgkin lymphoma studied by cytogenetic analysis, four new recurring translocations have been identified--t(8;9) (q24;p13), t(11;18)(q21;q21), t(14,15)(q32;q15), and an unbalanced translocation giving rise to der(22)t(17;22) (q11;p11). Each translocation appeared twice. The t(11;18) was the only karyotypic abnormality in the two patients with it, and the t(14;15) was the sole karyotypic abnormality in one patient. All translocations were found in B-cell malignancies and were associated with both nodal and extranodal disease. Among the regions affected, only the immunoglobulin heavy- chain gene MYC, and BCL2, have thus far been associated with lymphoma. The breakpoint sites identified by these translocations warrant further investigation at the molecular level.
Conjugated linoleic acid (CLA): effect modulation of body composition and lipid profile. (2009)

Conjugated linoleic acid (CLA) refers to a family of polyunsaturated fatty acids, being represented by a group of isomers of linoleic acid called conjugated for having a double bound after a simple bound. Among its isomers, trans-10,cis-12 and cis-9, cis-12 CLA stand out. These isomers can lead to different effects on the body: anticarcinogenic, antidiabetogenic, antiatherogenesis and positive body composition alteration. The objective of this review is to describe their mechanisms of action, effects on body composition, on plasmatic lipoproteins and supplementation. Studies about CLA supplementation show its capacity of reducing fat percentage, body mass and of promoting an improvement in lipid metabolism. One of the adverse effects attributed to one of the isomers is insulin resistance by body fat redistribution. Limitations in the scientific models used in CLA researches make impossible to draw conclusions about the action of this fatty acid on human metabolism.
Site-Directed Sulfhydryl Labeling of the Lactose Permease of <i>Escherichia coli</i>:  Helix X (2000)

Helix X in the lactose permease of Escherichia coli contains two residues that are irreplaceable with respect to active transport, His322 and Glu325, as well as Lys319, which is charge-paired with Asp240 in helix VII. Structural and dynamic features of transmembrane helix X are investigated here by site-directed thiol modification of 14 single-Cys replacement mutants with N-[14C]ethylmaleimide (NEM) in right-side-out membrane vesicles. Permease mutants with a Cys residue at position 326, 327, 329, 330, or 331 in the cytoplasmic half of the transmembrane domain are alkylated by NEM at 25 °C, a mutant with Cys at position 315 at the periplasmic surface is labeled in the presence of substrate exclusively, and mutants with Cys at positions 317, 318, 320, 321, 324, 328, 332, or 333 do not react with NEM under the conditions tested. Binding of substrate causes increased labeling of a Cys residue at position 315 and decreased labeling of Cys residues at positions 326, 327, and 329. Studies with methanethiosulfonate ethylsulfonate indicate that Cys residues at positions 326, 329, 330, and 331 in the cytoplasmic half are accessible to the aqueous phase from the periplasmic face of the membrane. Ligand binding results in clear attenuation of solvent accessibility of Cys at position 326 and a marginal increase in accessibility of Cys at position 327 to solvent. The findings indicate that the cytoplasmic half of helix X is more reactive/accessible to thiol reagents and more exposed to solvent than the periplasmic half. Furthermore, positions that reflect ligand-induced conformational changes are located on the same face of helix X as Lys319, His322, and Glu325.
Organic–inorganic halide perovskite/crystalline silicon four-terminal tandem solar cells (2014)

Tandem solar cells constructed from a crystalline silicon (c-Si) bottom cell and a low-cost top cell offer a promising way to ensure long-term price reductions of photovoltaic modules. We present a four-terminal tandem solar cell consisting of a methyl ammonium lead triiodide (CH3NH3PbI3) top cell and a c-Si heterojunction bottom cell. The CH3NH3PbI3 top cell exhibits broad-band transparency owing to its design free of metallic components and yields a transmittance of >55% in the near-infrared spectral region. This allows the generation of a short-circuit current density of 13.7 mA cm(-2) in the bottom cell. The four-terminal tandem solar cell yields an efficiency of 13.4% (top cell: 6.2%, bottom cell: 7.2%), which is a gain of 1.8%abs with respect to the reference single-junction CH3NH3PbI3 solar cell with metal back contact. We employ the four-terminal tandem solar cell for a detailed investigation of the optical losses and to derive guidelines for further efficiency improvements. Based on a power loss analysis, we estimate that tandem efficiencies of ∼28% are attainable using an optically optimized system based on current technology, whereas a fully optimized, ultimate device with matched current could yield up to 31.6%.
Wheat Cultivars Vary Widely in Their Responses of Grain Yield and Quality to Short Periods of Post-Anthesis Heat Stress (1994)

Short periods of high temperature (&gt; 35ºC) are common during the post-anthesis period in Australian wheat crops and have recently been shown to significantly reduce grain yield and quality. In view of this, 75 cultivars of wheat were screened for tolerance to 3 days of high temperature (max. 40ºC). Detailed results for grain yield and quality are presented for five wheat cultivars in order to illustrate the wide range of responses to short periods of high temperature. Individual kernel mass decreased by up to 23%, depending on variety, and the gliadin : glutenin ratio altered in the range -9 to +18% in response to high temperature treatment, also depending on variety. Noodle swelling power was significantly affected by heat in two cultivars, but there was no significant change due to heat in the apparent amylose content in any variety. The marked response of several yield and quality components to a heat treatment lasting only ca 5% of the grain-filling period suggests that starch and protein synthesis do not immediately andlor fully recover from short, severe heat stress. In addition, we conclude that wheat shows considerable genetic variability in tolerance to short periods of high temperature for both grain yield and quality.
An SVD approach to multi-camera-multi-target 3-D motion-shape analysis (2002)

An SVD approach to the so-called structure-from-motion problem was proposed by Tomasi and Kanade [1992]. The present paper extends the original motion-shape-estimation (MSE) to the multi-camera-multi-target case. The multi-target MSE problem is: given a sequence of 2D video images of multiple moving targets, the problem is to track the 3D motion of the targets and reconstruct their 3D shapes. This is further extended to multi-camera-multi-target MSE, with potential application to the 3D occlusion problem. After collection of feature points (FPs), which are sequentially tracked by a video system, the SVD may be applied to a measurement matrix formed by the FPs. The distribution of singular values would first reveal the information about the number of objects at hand. Then, using an algebraic-based subspace clustering method, the FPs may be mapped onto their corresponding objects. Thereafter, the motion and shape may be estimated from a matrix factorization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
VLSI Digital Signal Processors: An Introduction to Rapid Prototyping and Design Synthesis (1994)

Digital signal processors classification of architectures data/instruction memories VLSI SISC processors data path design, rapid prototyping multiprocessor architectures DSMP compilers formal methods for scheduling assignment and allocation special instruction set multi-chip computers (SIMC) video signal processors.
LiNbO <sub>3</sub> directional-coupler polarisation splitter (1987)

A Ti: LiNbO3 directional-coupler polarisation splitter is proposed. The device has the same structure as directional-coupler switches with reversal Δβ electrodes. The principles on which it operates and the measured characteristics of a sample device are presented.
Accurate Determination of Dew Point (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAccurate Determination of Dew PointArthur W. Hixson and G. Edwin WhiteCite this: Ind. Eng. Chem. Anal. Ed. 1938, 10, 5, 235–240Publication Date (Print):May 1, 1938Publication History Published online1 May 2002Published inissue 1 May 1938https://pubs.acs.org/doi/10.1021/ac50121a002https://doi.org/10.1021/ac50121a002research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
[Primary melanoma of the central nervous system]. (2000)

Primary melanomas are extremely rare tumors of the central nervous system. Surgical removal of the lesion may result in prolonged remission or cure.
Electric myocardial impedance registration in humoral rejection after heart transplantation. (1996)

We conclude that the registration of the electric myocardial impedance diagnoses humoral rejection episodes after heart transplantation not only reliably but also early, that is, before the onset of irreversible graft damage.
User attitudes to concatenated natural speech and text-to-speech synthesis in an automated information service (1999)

This paper presents a new approach to tone modeling for continuous Mandarin speech recognition. Mandarin tones provide rich information for speech recognition. In this paper, we treat the tone as an attribute of the final vowel part of a Mandarin syllable. Separate distributions are estimated for cepstral coefficients and pitch features respectively, and the phonetic state tied-mixture technique is exploited to achieve improved modeling. Several tying structures are investigated, and the results are compared with that without using tonal parameters. After integrating tone models, decent improvements can be achieved in large vocabulary continuous Mandarin speech recognition. Besides, this approach can be easily incorporated into the one-pass Viterbi search framework for practical implementation of Mandarin dictation system.
Multivariable Control of a Submersible using the LQG/LTR Design Methodology (1986)

A multivariable feedback control system is designed for a submersible. The control variables are the bow, rudder, and differential stern control surfaces; these are dynamically coordinated so as to cause the vehicle to follow independent and simultaneous commanded changes in yaw rate, depth rate, pitch attitude, and roll angle. Two designs were evaluated using a nonlinear submersible simulation. One used all four control variables so that active roll control was possible. The other used only three control variables, and active roll control was not employed. Both feedback systems were designed using the Linear Quadratic Gaussian (LQG) with Loop Transfer Recovery (LTR) design methodology so as to meet similar design specifications in the frequency domain. Both the linearized models, and the non-linear simulation have shown that active roll control yields a very significant improvement in submersible performance. Active roll control minimized unwanted depth changes in difficult commanded trajectory scenarios.
1 cm thick HgI/sub 2/ gamma-ray spectrometers (2005)

Thick mercuric iodide (HgI/sub 2/) detectors are investigated as potential room temperature gamma-ray spectrometers. By using pixelated anodes the induced charge on the electrode is dependent mainly on electron movement and is almost independent of the depth of interaction. Moreover, by reading out the planar cathode signal simultaneously, the depth of interaction can be determined and any effects of electron charge loss can be corrected. We present recent results from a new 1 cm thick pixelated HgI/sub 2/ gamma-ray spectrometer where the pixels have been moved next to each other. Depth corrected resolutions under 2% from a Cs-137 (662 keV) source have been observed while operating these detectors at a relatively low electric field (2500 V/cm) and modest shaping times (4-16 /spl mu/s). The large surrounding anode was also connected, allowing for the observation of the pulse waveforms on the large non-collecting anode. This allowed for the observation of electron charge sharing between the anode pixel and surround large anode.
Fractionated Extraction of Total Tissue Proteins from Mouse and Human for 2-D Electrophoresis (2003)

The protocol for extracting proteins from mouse and human tissues (organs) described in this chapter follows a strategy that is based on the intention to include all the various protein species of a particular tissue in a set of samples that are suitable for two-dimensional electrophoresis (2-DE), particularly for the large gel 2-DE technique described in Chapter 18. The aim then is the resolution and visualization of all these protein species in 2-DE gels. This aim explains some features of our tissue extraction procedure for gaining the proteins. Fractionation of total tissue proteins was preferred to a one-step extraction of all proteins. Using the fractionation procedure, the many different protein species of a tissue can be distributed over several 2-DE gels, and this increases resolution. However, a postulate is that fractionation of tissue proteins results in fraction-specific proteins. To achieve this, cell fractionation is usually performed with the aim of isolating special cell organelles (nuclei, mitochondria) or cell structures (membranes). The proteins are then extracted from these natural fractions. This procedure, however, includes washing steps to purify the cell fractions, and the elimination of cell components that are not of interest and cell residues, which are rejected. Using this procedure, an uncontrolled loss of proteins is unavoidable.
Design Overview of a Three Kilowatt Recuperated Ceramic Turboshaft Engine (2010)

A three kilowatt turboshaft engine with a ceramic recuperator and turbine has been designed for small unmanned air vehicle (UAV) propulsion and portable power generation. Compared with internal combustion (IC) engines, gas turbines offer superior reliability, engine life, noise and vibration characteristics, and compatibility with military fuels. However, the efficiency of miniature gas turbines must be improved substantially, without severely compromising weight and cost, if they are to compete effectively with small IC engines for long-endurance UAV propulsion. This paper presents a design overview and supporting analytical results for an engine that could meet this goal. The system architecture was chosen to accommodate the limitations of mature, cost-effective ceramic materials: silicon nitride for the turbine rotors and toughened mullite for the heat exchanger and turbine stators. An engine with a cycle pressure ratio below 2:1, a multistage turbine, and a highly effective recuperator is shown to have numerous advantages in this context. A key benefit is a very low water vapor-induced surface recession rate for silicon nitride, due to an extremely low partial pressure of water in the combustion products. Others include reduced sensitivity to internal flaws, creep, and foreign object damage; an output shaft speed low enough for grease-lubricated bearings; and the potential viability of a novel premixed heat-recirculating combustor.
A dual band mm-wave CMOS oscillator with left-handed resonator (2009)

A new technique using left-handed resonator to generate multi-band mm-wave carrier signal is proposed in this paper. The left-handed resonator exhibits non-linear dispersion characteristic which enables uneven spacing between resonant frequencies. A dual band mm-wave oscillator in 90nm CMOS technology is implemented to demonstrate this new technique. Using a mode selection switch, the proposed oscillator operates at 21.3GHz and 55.3GHz respectively with a total power consumption of 14mW.
Isolation and characterization of a 2.3-kilobase-pair cDNA fragment encoding the binding domain of the bovine leukemia virus cell receptor (1993)

An immunoscreening strategy was used to isolate a cDNA clone encoding the binding domain for the external glycoprotein gp51 of the bovine leukemia virus (BLV). Three recombinant phages demonstrating BLV binding activity and containing 2.3-kbp cDNA inserts with identical nucleotide sequences were isolated from a lambda gt11 cDNA library of bovine kidney cells (MDBK). One clone, BLVRcp1, hybridized with a 4.8-kb mRNA from cells of bovine origin and was also found to be conserved as a single-copy gene in murine, bovine, ovine, primate, canine, feline, and porcine DNAs. The same gene is amplified in caprine DNA isolated from a BLV-induced tumor. The longest open reading frame of BLVRcp1 encodes a protein fragment of 729 amino acids with a putative receptor structure. BLVRcp1 cDNA was cloned in the eucaryotic expression vector pXT-1 and transfected into murine NIH 3T3 and human HEp-2 cells. Cells expressing BLVRcp1 mRNA became susceptible to BLV infection. BLVRcp1 has no known physiological function and has no significant homology with sequences registered in the GenBank and EMBL data libraries (31 July 1992). Expression of deleted constructs of BLVRcp1 indicates that the BLV binding region is encoded at the 5' side of the receptor clone.
Identification and preliminary characterization of a 65 kDa higher-plant microtubule-associated protein (1993)

Microtubules in plant cells, as in animal cells, are dynamic structures. However, our lack of knowledge about the constituents of microtubules in plant cells has prevented us from understanding the mechanisms that control microtubule dynamics. To characterize some of these constituents, a cytoplasmic extract was prepared from evacuolated protoplasts (miniprotoplasts) of tobacco BY-2 cells, and microtubules were assembled in the presence of taxol and disassembled by cold treatment in the presence of Ca2+ and a high concentration of NaCl. SDS-PAGE analysis of triple-cycled microtubule protein revealed the presence of 120 kDa, 110 kDa and a group of 60-65 kDa polypeptides in addition to tubulin. Since these polypeptides had copolymerized with tubulin, through the three cycles of assembly and disassembly, and they bundle microtubules, we tentatively identified the three polypeptides as microtubule-associated proteins (MAPs). To characterize these factors further, triple-cycled microtubule protein was fractionated by Mono-Q anion-exchange chromatography and the microtubule-bundling activity of each fraction was examined. Fractions having microtubule-bundling activity contained only the 65 kDa MAP, an indication that the 65 kDa MAP is responsible for the bundling of microtubules. Purified 65 kDa MAP formed cross-bridge structures between adjacent microtubules in vitro. Polyclonal antibodies were raised in mice against the 65 kDa MAP. Immunofluorescence microscopy revealed that the 65 kDa MAP colocalized with microtubules in BY-2 cells throughout the cell cycle. Western blotting analysis of extracts from several species of plants suggested that the 65 kDa MAP and/or related peptides are widely distributed in the plant kingdom.
HVDC Models Used in Stability Studies (1989)

Power system ac/dc stability simulation results obtained using three types of HVDC models are compared. The difference in results is shown to be much smaller than the level of uncertainty inherently involved in stability calculations. The theoretical basis for the two commonly used types of HVDC models is discussed and a third model is introduced which uses less computer time than the most detailed model and is more accurate than the simpler model. AC system harmonics and asymmetries cannot generally be represented in power system stability programs so the effects of harmonics and asymmetries on the HVDC system also cannot be modeled. Simulation results obtained using different assumptions regarding the HVDC converters response to ac system asymmetries, different assumptions regarding commutation failure and different ac system load models are compared to estimate the level of uncertainty inherent in the normal stability calculations.
The Impact of Capital and Foreign Exchange Flowson the Competitiveness of Developing Countries (2010)

for useful comments, and Yasmina Zinbi and Naseebah Hajjaj for editorial
Cyclohexylamine and Dicyclohexylamine (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclohexylamine and DicyclohexylamineT. S. Carswell and H. L. MorrillCite this: Ind. Eng. Chem. 1937, 29, 11, 1247–1251Publication Date (Print):November 1, 1937Publication History Published online1 May 2002Published inissue 1 November 1937https://pubs.acs.org/doi/10.1021/ie50335a011https://doi.org/10.1021/ie50335a011research-articleACS PublicationsRequest reuse permissionsArticle Views659Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Targeting Inflammation: Multiple Innovative Ways to Reduce Prostaglandin E <sub>2</sub> (2013)

The PGE2 pathway is important in inflammation-driven diseases and specific targeting of the inducible mPGES-1 is warranted due to the cardiovascular problems associated with the long-term use of COX-2 inhibitors. This review focuses on patents issued on methods of measuring mPGES-1 activity, on drugs targeting mPGES-1 and on other modulators of free extracellular PGE2 concentration. Perspectives and conclusions regarding the status of these drugs are also presented. Importantly, no selective inhibitors targeting mPGES-1 have been identified and, despite the high number of published patents, none of these drugs have yet made it to clinical trials.