gebhart/patrepeval huggingface dataset:
The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo. (1994)

Recent in vitro results suggest that the heterogeneous nuclear ribonucleoparticle (hnRNP) A1 protein modulates alternative splicing by favoring distal 5' splice site (5'SS) selection and exon skipping. We used a mouse erythroleukemia (MEL) cell line (CB3C7) deficient in the expression of hnRNP A1 to test whether variations in hnRNP A1 and AlB protein levels affected alternative splicing in vivo. In contrast to A1-expressing MEL cell lines, CB3C7 cells preferentially selected the proximal 13S and 12S 5'SS on the adenovirus E1A pre-mRNA. Transiently expressing the A1 or A1B cDNA in CB3C7 cells shifted 5'SS selection toward the more distal 9S donor site. A1 protein synthesis was required for this effect since the expression of a mutated A1 cDNA did not affect 5'SS selection. These results demonstrate that in vivo variations in hnRNP A1 protein levels can influence 5'SS selection.
The garment sector in Cambodia : post-MFA outlook (2004)

In the lead up to the expiration of garment quotas at the end of 2004, there were serious concerns about the prospects for Cambodia's garment sector, and the estimated 230,000 jobs it has created. What follows is a summary of recent donor agency reports as well as comments from industry experts that highlight the garment industry's significance to the local economy, its competitive characteristics, the constraints it faces, and the prospects for its survival after the ending of the quota system. The paper recommends Cambodia enhance its competitiveness by building on its strength as a country with high labor standards and that the government should improve infrastructure and reduce infrastructure-related costs
Fast proton spectroscopic imaging employing <i>k</i>‐space weighting achieved by variable repetition times (1996)

A k-space weighted spectroscopic imaging (SI) method is presented that allows a reduction in the total data acquisition time by up to 55% compared with standard SI. The k-space weighting is achieved by varying the repetition time, thus realizing an inherent apodization that corresponds to a circularly symmetric generalized Hamming filter. The flip angle is varied with the repetition time to enhance the signal-to-noise ratio. These techniques were employed using a short echo time of 10 ms. In vivo measurements on healthy rat brain at 4.7 T were conducted, obtaining two-dimensional spectroscopic imaging data from a 25 x 25 circularly reduced k-space area in as little as 5 min. The signal-to-noise ratio is sufficiently high to detect J-coupled resonances such as myo-inositol or glutamate/glutamine, demonstrating the ability to combine short acquisition times with comprehensive metabolic information. The T1 dependency of the apodization and the corresponding point spread function was evaluated by computer simulations. The achievable signal-to-noise ratio per unit time was compared with standard SI giving a parameter-dependent advantage of approximately 20% of the standard SI method.
Two View Geometry Estimation with Outliers (2009)

We study the relative orientation problem for two calibrated cameras with outliers from the feature matching. In recent years there has been a growing interest in optimal algorithms for computer vision. Most people agree that to get accurate solutions to multiview geometry problems, an appropriate norm of the reprojection errors should be minimized. To this end local as well as global optimization methods have been employed. To handle outliers though, heuristic methods still dominate the field. In this paper we address the problem of estimating relative orientation from uncertain feature correspondences. We formulate this task as an optimization problem and propose a branchand-bound algorithm to find the optimal set of correspondences as well as the optimal relative orientation. The approach is based on geometric constraints for pairs of correspondences. The experimental results are promising, especially for omnidirectional cameras. An implementation of the algorithm is also made publicly available to facilitate further research.
Transmitter diversity for OFDM systems and its impacts on high-rate wireless networks (2003)

Transmitter diversity and down-link beamforming can be used in high-rate wireless networks with OFDM for capacity improvement. In this paper, we compare the performance of delay, permutation and space-time coding transmitter diversity for OFDM systems, and its impact on high-rate packet data wireless networks, where relatively high block error rates, such as, 10%, on the wireless links are acceptable using ARQ. As an alternative, we also consider using the same number of transmitter antennas for down-link beamforming in the direction of the desired mobiles. Our investigation indicates that the delay transmitter diversity with QPSK modulation and adaptive antenna arrays can provide good quality of service (QoS) with a low retransmission probability while space-time coding transmitter diversity can provide high peak-rate. However, down-link beamforming together with adaptive antenna arrays, if it is applicable, appears to be a better alternative to transmitter diversity.
VICROADS' HAZARDOUS POLES PROGRAM. (1994)

VicRoads has developed a program for treating hazardous roadside poles. This paper encompasses the development of the program, the types of pole treatment possible and project funding. Additional benefits of the program, results to date and project research are also discussed.
Physical fundamentals of laser forming of micro-optical components (1994)

The possibility of micro-optical component (MOC) fabrication by laser action onto optical glasses and glass-like material (GLM) is based on the local heating-cooling cycle. The results of such action are certain to be defined by physical processes that accompany local heating and fast cooling of glass and GLM. It is possible to classify these laser action processes on the optical materials in three main groups in terms of temperature, heating and cooling rates, and the size of residual stresses. The presented facts suggest that during laser heating, the processes of changing the structure and properties of glasses and GLM differ by speed and temperature from processes that occur at heating in a furnace.
Potential antitrypanosomal agents. 1,N2-Disubstituted 2-amino-5-hydroxy-4-methylnaphtho[1,2-d]thiazolium salts and related compounds (1982)

A series of 1-alkyl-2-(substituted-amino)-5-hydroxy-4-methylnaphtho[1,2-d]thiazoles having in vitro trypanocidal activity is described. Several caused complete lysis of Trypanosoma brucei organisms within 30 min at 10(-5) M. The presence of a hydrophobic substituent on the 2-amino group was associated with high antitrypanosomal activity. Some analogues unsubstituted at the 1-position, a known class of compounds, were also active. None of the derivatives significantly prolonged the survival of T. brucei infected mice. Inhibition of activity in vitro by bovine serum albumin was observed. Because of the structural novelty of these agents in comparison with known trypanocides, their mechanism of action warrants further investigation.
Visual Methods for Analyzing Time-Oriented Data (2007)

Providing appropriate methods to facilitate the analysis of time-oriented data is a key issue in many application domains. In this paper, we focus on the unique role of the parameter time in the context of visually driven data analysis. We will discuss three major aspects - visualization, analysis, and the user. It will be illustrated that it is necessary to consider the characteristics of time when generating visual representations. For that purpose we take a look at different types of time and present visual examples. Integrating visual and analytical methods has become an increasingly important issue. Therefore, we present our experiences in temporal data abstraction, principal component analysis, and clustering of larger volumes of time-oriented data. The third main aspect we discuss is supporting user-centered visual analysis. We describe event-based visualization as a promising means to adapt the visualization pipeline to needs and tasks of users.
The entanglement plateau in the dynamic modulus of rubbery styrene–diene block copolymers. Significance to pressure-sensitive adhesive formulations (1977)

Styrene–diene (butadiene or isoprene) block copolymers of the SDS or $ ({\rm SD\rlap{--} )} $ type exhibit a plateau in the dynamic storage modulus located between the glass transitions of the polydiene and polystyrene domains. When the polydiene is the continuous phase, the height of this plateau can be estimated with good success from the entanglement spacing molecular weight of the polydiene and the filler effect of the polystyrene domains. The effect of introduction of a center block-compatible diluent can also be calculated, although the simple procedure used here tends to underestimate the plasticizer effect, particularly at high diluent concentration. Nevertheless, the calculation furnishes a useful criterion of compatibility of the polydiene center blocks and low molecular weight resins used commonly as tackifiers in pressure-sensitive adhesives. Center block compatibility is essential for the development of tack in these compositions.
Side-Cutting Aspiration Device for Endoscopic and Microscopic Tumor Removal (2012)

The authors present a unique side-cutting instrument (NICO Myriad, Indianapolis, IN) with variable aspiration designed specifically for tumor resection. The study included retrospective review of data collected from 10/2009 to 01/2011. We detail the use of the Myriad in 31 patients with the following pathologies: meningioma (n=16), chordoma (n = 3), schwannoma (n = 3), pituitary adenoma (n = 2), metastasis (n = 3), hemangioblastoma (n = 1), craniopharyngioma (n = 1), and nasopharyngeal tumors (n = 2). Surgical approaches included expanded endonasal approach (n = 19), endoscopic brain port (n = 3), supraorbital "eyebrow" craniotomy (n = 3), retrosigmoid suboccipital craniotomy (n = 3), pterional craniotomy (n = 1), extreme far lateral (n = 1), and laminectomy (n = 1). Successful tumor resection was achieved in 30 cases. Instrument failure was noted in only one extremely fibrous meningioma. The design of this instrument facilitated maneuvering through narrow corridors while providing direct visualization of the suction aperture during tumor resection. These features allowed for tumor removal without injury to adjacent neurovascular structures. The side-cutting aspiration device allows safe and effective tumor removal. Its low profile, variable aspiration, and lack of thermal heat energy are particularly useful in tumor resection through narrow corridors, such as endonasal, port, and keyhole approaches. The multifunctional nature of the instrument (suction, scissors, and dissectors) minimizes multiple exchanges, facilitating tumor resection through these minimal access corridors.
Mono- and Bis-α-diketones and Related Polymers (1977)

Published information on the methods of preparation and the reactions of mono- and bis-α-diketones is reviewed. Special attention is paid to use of the latter to obtain heat-resistant and thermostable polymers, in particular polyphenylquinoxalines. A list of 201 references is included.
[First clinical experiences with cholestyramine for the prophylaxis of stress ulcer (author's transl)]. (1977)

In a general and accident surgical intensive care ward, the possibility of prophylaxis with the exchange resin cholestyramine (which combines with bile acids) was investigated in 68 patients threatened by stress ulcers. Whereas two patients in the control group treated with an antacid (N = 24) developed deep stress ulcers, only one patient among those treated with cholestyramine alone (N=8) developed superficial erosions; no bleeding occurred at all when it was combined with an antacid (N=36). Entefal tolerance of cholestyramine was good during parenteral feeding. No side-effects were observed. The elimination of the ulcerogenic function of duodenogastric reflux in stress ulcer is discussed as a mode of action.
Aptamers that recognize drug-resistant HIV-1 reverse transcriptase (2008)

Drug-resistant variants of HIV-1 reverse transcriptase (RT) are also known to be resistant to anti-RT RNA aptamers. In order to be able to develop diagnostics and therapies that can focus on otherwise drug-resistant viruses, we have isolated two aptamers against a well-known, drug-resistant HIV-1 RT, Mutant 3 (M3) from the multidrug-resistant HIV-1 RT panel. One aptamer, M302, bound M3 but showed no significant affinity for wild-type (WT) HIV-1 RT, while another aptamer, 12.01, bound to both M3 and WT HIV-1 RTs. In contrast to all previously selected anti-RT aptamers, neither of these aptamers showed observable inhibition of either polymerase or RNase H activities. Aptamers M302 and 12.01 competed with one another for binding to M3, but they did not compete with a pseudoknot aptamer for binding to the template/primer cleft of WT HIV-1 RT. These results represent the surprising identification of an additional RNA-binding epitope on the surface of HIV-1 RT. M3 and WT HIV-1 RTs could be distinguished using an aptamer-based microarray. By probing protein conformation as a correlate to drug resistance we introduce an additional and useful measure for determining HIV-1 drug resistance.
Architectural PTFE-Coated Glass Fabrics—Their Structure and Limitations (1983)

PTFE-coated glass fabrics, used as membranes for advanced architectural tension structures, offer advantages over conventional low cost coated fabrics in terms of their chemical stability, mechanical properties, and expected service life. These ma terials have a high shear stiffness, however, and the brittle behavior of glass fibers necessitates careful handling. The structure and performance of several commercial PTFE-coated fabric systems were investigated by scanning electron microscopy, mechanical testing, and weathering in artificial and natural environments. Acoustic emission analysis demonstrated that these flexible coated fabrics respond to stress in a predictable manner similar to rigid composite materials. The susceptibility of these materials to bending and fatigue loads was confirmed in flexure tests. Sintered PTFE coatings contain pinholes and regions of surface rupture around glass sphere filler particles. Exposure of coated fabrics to hot moist environments and to the natural environment, when loaded uniaxially outdoors, results in further surface damage. PTFE coatings are likely to incur progressive surface damage during envi ronmental exposure in architectural membranes, leading to possible damage to the underlying glass fabric.
Tafenoquine versus Primaquine to Prevent Relapse of <i>Plasmodium vivax</i> Malaria (2019)

Among patients with normal G6PD enzyme activity, the decline in hemoglobin level with tafenoquine did not differ significantly from that with primaquine. Tafenoquine showed efficacy for the radical cure of P. vivax malaria, although tafenoquine was not shown to be noninferior to primaquine. (Funded by GlaxoSmithKline and Medicines for Malaria Venture; GATHER ClinicalTrials.gov number, NCT02216123 .).
CETP Gene and Its Role in Diabetes Mellitus Type II - A Review (2016)

Plasma lipoproteins are continuously remodelled through the actions of enzymes and lipid transfer proteins. In particular, the transfers of cholesteryl esters (CE) and triglycerides (TG) are facilitated by a specialized protein known as the cholesteryl ester transfer protein (CETP). Genetic polymorphisms of the enzymes and proteins involved in lipid metabolism like cholesteryl ester transfer protein CETP have been shown to affect plasma lipid concentrations. CETP modifies HDL, LDL and very low density lipoprotein (VLDL) levels. It transfers cholesterol esters (CE) from CE rich particles (HDL and LDL) to triglyceride rich particles (VLDL) in exchange of triglyceride from the latter. Several genetic polymorphisms have been reported which may be associated with alteration in CETP activity. TaqI B polymorphism has been most widely studied, which results from a silent mutation in nucleotide 277, in intron 1 of the gene. The polymorphism has been associated with decreased CETP mass and an increase in HDL-cholesterol. The TaqI polymorphism B1 allele of CETP has been shown to be an independent risk factor for development of cerebral vascular disease, in patients with T2DM.
Creation of Transgenic Citrus Free from Limonin Bitterness (1996)

Bitterness due to limonin in citrus juices is a major problem for the citrus industry worldwide. Modern gene transfer methodology provides a promising approach for solving this problem. Basic research on the biosynthesis of limonoids in citrus fruit has shown the presence of several promising enzymes, if their activities could be genetically enhanced in or transferred to commercial species of citrus. Accomplishing this could lower the levels of the bitter limonoids in developing fruit. Two of these limonoid metabolic enzymes have been isolated and their amino acid sequences determined. Preparation of gene constructs for genetic transfer to navel orange is in progress
ChemInform Abstract: Synthesis and Electrochemical Properties of Some New Bipyridinium and Related Compounds. (1988)

Abstract The preparation of some novel viologens, viz.
Real-time state of charge and electrical impedance estimation for lithium-ion batteries based on a hybrid battery model (2013)

This paper proposes a real-time state of charge (SOC) and electrical impedance estimation method for lithium-ion batteries based on a hybrid battery model. The hybrid battery model consists of an enhanced Coulomb counting algorithm for SOC estimation and an electrical circuit battery model. A particle swarm optimization (PSO)-based online parameter identification algorithm is designed to estimate the electrical impedances and open-circuit voltage of the electrical circuit battery model. A SOC compensator is designed to correct the error of the Coulomb counting-based SOC estimation, leading to a closed-loop, accurate, robust real-time SOC estimation. The proposed method is validated by using experimental data collected from a battery tester for a polymer lithium-ion battery cell. The proposed method is applicable to other types of electrochemical battery cells.
Z/Os Version 1 Release 10 Implementation (2002)

This IBM Redbooks publication positions the new z/OS Version 1 Release 10 for migration by discussing many of the new functions that are available. The goal for the z/OS platform is to eliminate, automate, and simplify tasks without sacrificing z/OS strengths, and to deliver a z/OS management facility that is easy to learn and use. This release of the operating system supports new capabilities that are designed to provide the following enhanced and new functions: - An architectural limit of hundreds of terabytes (TBs) for DASD volumes, up from the current limit of approximately 54 GB per volume. Known as Extended Address Volume (EAV), this function is planned to initially support 223 GB per volume on z/OS V1R10 and IBM System StorageTM DS8000 , when available. - Up to 64 engines, up to 1.5 TB per server with up to 1.0 TB of real memory per LPAR, and support for large (1 MB) pages on the z10 EC, providing performance for critical workloads. - HiperDispatch can help provide increased scalability and performance of higher n-way z10 EC systems by improving the way workload is dispatched within the server. - A new Basic HyperSwapTM capability (to be enabled by TotalStorage Productivity Center for Replication Basic Edition for System z). - Improved management for processor capacity via a new Capacity Provisioning Manager. - Improved productivity with simplifying diagnosis and problem determination. - Expanded Health Check services. - Automatic dump and re-IPL capability.
zuo zuo jiao shi (2006)

3月27日,教育部举行新闻发布会,表达了清退代课教师、优化教师队伍的决心。全国44.8万代课教师的命运,因此而变得尴尬。而夹在教育部与代课教师之间的基层教育部门,在教育的现实面前无奈前行
Cutting Edge: Induction of IFN-γ Production but Not Cytotoxicity by the Killer Cell Ig-Like Receptor KIR2DL4 (CD158d) in Resting NK Cells (2001)

Abstract Activated NK cells lyse tumor cells and virus-infected cells and produce IFN-γ upon contact with sensitive target cells. The regulation of these effector responses in resting NK cells is not well understood. We now describe a receptor, KIR2DL4, that has the unique property of inducing IFN-γ production, but not cytotoxicity, by resting NK cells in the absence of cytokines. In contrast, the NK cell-activation receptors CD16 and 2B4 induced cytotoxicity but not IFN-γ production. The induction by KIR2DL4 of IFN-γ production by resting NK cells was blocked by an inhibitor of the p38 mitogen-activated protein kinase signaling pathway, in contrast to the IL-2-induced IFN-γ secretion that was sensitive to inhibition of the extracellular signal-regulated kinase mitogen-activated protein kinase pathway. These results reveal a functional dichotomy (cytokine production vs cytotoxicity) in the response of resting NK cells, as dictated by the signals of individual receptors.
Low-Temperature Oxidation Characteristics of Lignite Chars from Low-Temperature Pyrolysis (2014)

The oxidation characteristics of chars from low-temperature pyrolysis of two lignite coals have been systematically investigated using a dual fixed-bed quartz reactor and a thermogravimetric analyzer (TGA). During oxidation experiments, the temperature profiles of coal and char samples were recorded and CO2 and CO gases evolved were analyzed using gas chromatography. The physical and chemical structures of coals and chars were analyzed using Brunauer–Emmett–Teller (BET) adsorption isotherms and Fourier transform infrared spectroscopy (FTIR). During oxidation, the temperature of the coal sample may increase noticeably, exceeding the crossing point temperature (CPT). Chars prepared at 400 °C showed the lowest CPT, indicating the highest oxidation reactivity compared to that of parent coals and chars prepared at other temperatures. During oxidation, gaseous products are released, implying that oxygen-containing functional groups and solid oxygenated complexes decomposed and the yields increased with increasing the oxidation temperature. The amount of CO2 generation was proportional to that of CO with the molar ratio of CO2/CO at around 4.15 under the present experimental conditions. During non-isothermal oxidation, the concentration of OH and other oxygen-containing functional groups increased with increasing the oxidation temperature for char samples but decreased in the case of oxidized coal. During isothermal oxidation, the concentration of oxygen functional groups in coal decreased with increasing the oxidation temperature above 250 °C. Pre-oxidation of chars decreased their combustion reactivity measured on the TGA.
Successful transplantation of a lung allograft from a carbon monoxide-poisoning victim. (1992)

Donor availability remains the limiting factor to heart and lung transplantation. Donor selection criteria need to be continuously reassessed to expand the donor pool. The feasibility of organ donation from victims of carbon monoxide poisoning is unclear. We present a case of successful single lung transplantation from a carbon monoxide-poisoning victim.