gebhart/patrepeval huggingface dataset:
Expression and significance of NF-κB and P-glycoprotein in cervical cancer tissue before and after neoadjuvant chemotherapy (2011)

Objective To investigate the relationship between the expression of NF-κB and Pglycoprotein(P-gp) in cervical cancer tissue before and after neoadjuvant chemotherapy(NACT). Methods The mRNA and the protein expression levels of NF-κB and P-gp were determined by Real time-PCR and immunohistochemical assay respectively in cancer specimens from 40 cevical cancer patients, which were collected before and after NACT. Results The mRNA expression levels of NF-κB were 50. 340 ± 0. 780 and 67. 595 ± 0. 914 before and after NACT respectively, which showed significant difference statistically ( t = -73. 384 ,P ＜ 0. 01 ). We also found significant difference in the comparison between MDR1 mRNA expression before and after NACT(45. 800 ±0. 636 vs 62. 381 ±0. 743 ,t = -66. 582,P ＜0. 01 ). The positive rate of NF-κB protein expression before and after NACT were 50% ( 20/40 ), 80% ( 32/40 ) respectively, which showed significant difference statistically( χ2 = 7. 912, P = 0. 005 ). The positive rate of P-gp protein expression after NACT was significantly higher than that before NACT [ 40% ( 16/40 ) vs 70% ( 28/40 ), χ2 = 7. 273, P = 0. 007 ]The mRNA and protein expressions of NF-κB were positively correlated with those of P-gp before and after NACT( r = 0. 408,r = 0. 327 respectively, Ps ＜ 0. 05 ). Conclusion NF-κB and P-gp may play an important role in multi-drug resistance of cervical carcinoma. Chemotherapy drugs in our NACT strategy may induce the activation of NF-κB and multi-drug resistance. Activation of NF-κB may correlate with multi-drug resistance mediated by P-gp.

Key words: 
Cervical carcinoma;  NF-κB;  P-glycoprotein;  Multi-drug resistance;  Neoadjuvant chemotherapy
Early sexual abuse and low cortisol (2001)

Post-traumatic stress disorder (PTSD) is a mental health disorder precipitated by a stressful event that produces fear or terror in the individual. Post-traumatic stress disorder studies, particularly in early sexual abuse, have been associated with neuroendocrine dysfunction, most notably the hypothalamic-pituitary-adrenal (HPA) axis. Since the literature on PTSD and neuroendocrine factors in young subjects has been sparse, the present studies were designed to look at the basal functioning of the HPA axis in response to early sexual abuse in girls aged 5 to 7 years. Morning salivary samples were collected for cortisol determination from subjects and controls who were scheduled for a physical exam by their pediatrician. The present study shows that subjects who had been abused within the last couple of months had significantly lower cortisol in comparison to control subjects (age, social economic status and race matched). The data suggest that children may have an impaired HPA axis after early trauma.
Magnetically quiet shipboard-type electrical equipment: methods in design and manufacturing (2002)

Magnetic noise requirements depend dramatically on the location of shipboard type equipment relative to the magnetic sensing devices of different types. Sometimes a designer has to make these levels from 10 to 100 times lower to meet domestic or international regulations. The report presents an overview of the magnetic silencing as a technology program that allows designers and manufacturing engineers to use and update the suggested methods progressively. It is easier to accept successful design expertise thereby shrinking the development time for new magnetically quiet ships.
Lossless compression of digital audio using cascaded RLS-LMS prediction (2003)

This paper proposes a cascaded RLS-LMS predictor for lossless audio coding. In this proposed predictor, a high-order LMS predictor is employed to model the ample tonal and harmonic components of the audio signal for optimal prediction gain performance. To solve the slow convergence problem of the LMS algorithm with colored inputs, a low-order RLS predictor is cascaded prior to the LMS predictor to remove the spectral tilt of the audio signal. This cascaded RLS-LMS structure effectively mitigates the slow convergence problem of the LMS algorithm and provides superior prediction gain performance compared with the conventional LMS predictor, resulting in a better overall compression performance.
Numerical annealing of low-redundancy linear arrays (1993)

An algorithm is developed that estimates the optimal distribution of antenna elements in a minimum redundancy linear array. These distributions are used in thinned array interferometric imagers to synthesize effective antenna apertures much larger than the physical aperture. The optimal selection of antenna locations is extremely time consuming when large numbers of antennas are involved. This algorithm uses a numerical implementation of the annealing process to guide a random search for the optimal array configuration. Highly thinned low-redundancy arrays are computed for up to 30 array elements. These arrays are equivalent to the optimal solutions that are known for up to 11 elements. The arrays computed for 12-30 elements have the fewest redundancies reported to date.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Calsequestrin determines the functional size and stability of cardiac intracellular calcium stores: Mechanism for hereditary arrhythmia (2003)

Calsequestrin is a high-capacity Ca-binding protein expressed inside the sarcoplasmic reticulum (SR), an intracellular Ca release and storage organelle in muscle. Mutations in the cardiac calsequestrin gene (CSQ2) have been linked to arrhythmias and sudden death. We have used Ca-imaging and patch-clamp methods in combination with adenoviral gene transfer strategies to explore the function of CSQ2 in adult rat heart cells. By increasing or decreasing CSQ2 levels, we showed that CSQ2 not only determines the Ca storage capacity of the SR but also positively controls the amount of Ca released from this organelle during excitation-contraction coupling. CSQ2 controls Ca release by prolonging the duration of Ca fluxes through the SR Ca-release sites. In addition, the dynamics of functional restitution of Ca-release sites after Ca discharge were prolonged when CSQ2 levels were elevated and accelerated in the presence of lowered CSQ2 protein levels. Furthermore, profound disturbances in rhythmic Ca transients in myocytes undergoing periodic electrical stimulation were observed when CSQ2 levels were reduced. We conclude that CSQ2 is a key determinant of the functional size and stability of SR Ca stores in cardiac muscle. CSQ2 appears to exert its effects by influencing the local luminal Ca concentration-dependent gating of the Ca-release channels and by acting as both a reservoir and a sink for Ca in SR. The abnormal restitution of Ca-release channels in the presence of reduced CSQ2 levels provides a plausible explanation for ventricular arrhythmia associated with mutations of CSQ2.
Emerging Materials for Civil Infrastructure: State of the Art (2000)

This special publication presents a review of the state of the art on emerging materials for use in civil engineering infrastructure. Emerging materials include novel and new materials, as well as traditional materials with profound potential in new applications. A material or class of materials is considered emerging if its use has not yet developed to a stage wherein well established guidelines, codes, and specifications exist for its use. This book is conveniently divided into chapters that address specific classes of materials highlighting the most recent developments in materials technologies relevant to civil infrastructure. The practicing engineer, student, or lay reader will find this to be an easy-to-use reference for a number of construction material systems that are increasingly being developed and considered for use in civil engineering. Topics covered include: smart materials for civil engineering applications; fiber reinforced composites in civil infrastructure; emerging geomaterials for ground improvement; aluminum materials and the infrastructure; polymer concrete made with recycled plastics; state of the practice in asphalt technology; emerging uses for masonry materials; and emerging uses for window glass.
Physiological induction and reversal of focus formation and tumorigenicity in NIH 3T3 cells. (1990)

NIH 3T3 cells undergo morphological transformation in response to conditions of constrained growth, such as occur in low serum concentrations or at confluence. Transformation is expressed in a small fraction of the cells by the appearance of discrete foci of multiplying cells on a confluent monolayer of quiescent cells. We isolated and expanded cell populations from three dense and three light foci. Cells from each of these populations efficiently reproduced foci of the same morphotype when grown on a background of nontransformed NIH 3T3 cells. Using cultures derived from one of the dense foci (subline D/2), we found that the number of focus-forming units was stable and the cells remained tumorigenic when they were subjected to repeated thrice-weekly passage in 2% calf serum. However, equivalent passage in 10% calf serum eventually rendered the cells incapable of both focus production and tumor formation. The results show that the capacity to produce tumors as well as morphological transformation are produced as a response to physiological constraints of growth and/or metabolism in the absence of carcinogens and that both properties can be reversed by lifting the constraints. This behavior is typical of an adaptational response and, taken together with other supporting evidence, shows that tumorigenesis does not require conventional genetic alteration.
Practical realisation of mod <i>p</i> , <i>p</i> prime multiplier (1980)

A practical realisation of a mod p, p prime multiplier for the case p = 2n−2k+1, k<n is described. Simulated results are presented and speed metrics based on state-of-the-art memory technology are computed.
Electrolytics and Film Capacitors Continue to Evolve [Happenings] (2018)

Electrolytics and film capacitors continue to evolve power electronics engineers know that the most important component in a modern power conversion device is the solid- state switch. The properties of this device have widespread impact on the performance achieved in any converter, and advancements in the capabilities of new switch products are widely reported and closely followed. However, filter capacitors are also important components. In fact, much of the volume of any converter is normally taken up by these components and still more is given to other parts that serve to keep these components cool. Indeed, a considerable part of the design process for a converter is devoted to the selection and application of filter capacitors.
The Effect of Component of Cream for Topical Delivery of Hesperetin (2010)

The aim of this study was to optimize hesperetin cream formulations by in vitro permeation study and evaluate topical whitening active effect and skin irritation by in vivo study. The results showed that the solubility of lipophilic compound of hesperetin was increased by short-chain alcohol including ethanol, glycerin, propylene glycol and polyethylene glycols 400 (PEG 400). PEG 400 showed strongest solubilized effect by increased 3400-fold. With the addition of 5% enhancers, it was found that menthol showed the most potent enhancing effect, followed by azone and depigmentation agents (linoleic acid and lecithin). Moreover, enhancers could shorten the lag time from 3.7 to 1 h. Combination of menthol, linoleic acid and lecithin of 2.5% had a higher permeation rate of 9.8 microg/cm(2)/h and lower lag time 1 h, therefore the formulation was selected to process the skin whitening and irritation test. The results showed that a significantly topical photoprotective effect with acceptable skin irritation was obtained after hesperetin cream topical application when compared with that of the non-treatment group, indicating that the hesperetin cream may be used as an effective whitening agent.
An Image Inpainting Technique Based on the Fast Marching Method (2004)

Abstract Digital inpainting provides a means for reconstruction of small damaged portions of an image. Although the inpainting basics are straightforward, most inpainting techniques published in the literature are complex to understand and implement. We present here a new algorithm for digital inpainting based on the fast marching method for level set applications. Our algorithm is very simple to implement, fast, and produces nearly identical results to more complex, and usually slower, known methods. Source code is available online.
Methodology for Verifying the load limit point and bottle-neck of a game server using the large scale virtual clients (2008)

In this work, we propose the methodology for verifying the load limit point of a game server using the large scale virtual clients. It helps to reduce the testing time and to find the load limit point of servers. It explicitly secures the stability of the server for networked virtual environment and at the same time, it elaborately generates actual loads for testing the performance of the server. Our agent based load testing architecture provides variety of interactions of virtual entities in the virtual worlds to perform realistic simulations. Simulation results show that our proposed method ensures the stability and capacity of the servers.
Next Generation DHCP Deployments (2005)

Dynamic Host Configuration Protocol has facilitated mobile computing and made life easier for system administrators. This article examines some of the unique security problems found in DHCP environments, including a new technique for passively and remotely fingerprinting hosts using the protocol.
Casualty Detection from 3D Point Cloud Data for Autonomous Ground Mobile Rescue Robots (2018)

One of the most important features of mobile rescue robots is the ability to autonomously detect casualties, i.e. human bodies, which are usually lying on the ground. This paper proposes a novel method for autonomously detecting casualties lying on the ground using obtained 3D point-cloud data from an on-board sensor, such as an RGB-D camera or a 3D LIDAR, on a mobile rescue robot. In this method, the obtained 3D point-cloud data is projected onto the detected ground plane, i.e. floor, within the point cloud. Then, this projected point cloud is converted into a grid-map that is used afterwards as an input for the algorithm to detect human body shapes. The proposed method is evaluated by performing detections of a human dummy, placed in different random positions and orientations, using an on-board RGB-D camera on a mobile rescue robot called ResQbot. To evaluate the robustness of the casualty detection method to different camera angles, the orientation of the camera is set to different angles. The experimental results show that using the point-cloud data from the on-board RGB-D camera, the proposed method successfully detects the casualty in all tested body positions and orientations relative to the on-board camera, as well as in all tested camera angles.
Metal ion-assisted stacking interactions and the facilitated hydrolysis of nucleoside 5 ¢ -triphosphates (1998)

Abstract
Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella (1991)

Flagellar filaments were isolated from Helicobacter pylori by shearing, and flagellar proteins were further purified by a variety of techniques, including CsCl density gradient ultracentrifugation, pH 2.0 acid disassociation-neutral pH reassociation, and differential ultracentrifugation followed by molecular sieving with a Sephacryl S-500 column or Mono Q anion-exchange column, and purified to homogeneity by preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis and transfer to an Immobilon membrane. Two flagellin species of pI 5.2 and with apparent subunit molecular weights (Mrs) of 57,000 and 56,000 were obtained. N-terminal amino acid analysis showed that the two H. pylori flagellin species were related to each other and shared sequence similarity with the N-terminal amino acid sequence of Campylobacter coli, Bacillus, Salmonella, and Caulobacter flagellins. Analysis of the amino acid composition of the predominant 56,000-Mr flagellin species isolated from two strains showed that it was comparable to the flagellins of other species. The minor 57,000-Mr flagellin species contained a higher content of proline. Immunoelectron microscopic studies with polyclonal monospecific H. pylori antiflagellin antiserum and monoclonal antibody (MAb) 72c showed that the two different-Mr flagellin species were located in different regions of the assembled flagellar filament. The minor 57,000-Mr species was located proximal to the hook, and the major 56,000-Mr flagellin composed the remainder of the filament. Western immunoblot analysis with polyclonal rabbit antisera raised against H. pylori or Campylobacter jejuni flagellins and MAb 72c showed that the 56,000-Mr flagellin carried sequences antigenetically cross-reactive with the 57,000-Mr H. pylori flagellin and the flagellins of Campylobacter species. This antigenic cross-reactivity did not extend to the flagellins of other gram-negative bacteria. The 56,000-Mr flagellin also carried H. pylori-specific sequences recognized by two additional MAbs. The epitopes for these MAbs were not surface exposed on the assembled inner flagellar filament of H. pylori but were readily detected by immunodot blot assay of sodium dodecyl sulfate-lysed cells of H. pylori, suggesting that this serological test could be a useful addition to those currently employed in the rapid identification of this important pathogen.
Cryptographic Key Management for Smart Power Grids - Approaches and Issues (2012)

The smart power grid promises to improve efficiency and reliability of power delivery. This report introduces the logical components, associated technologies, security protocols, and network designs of the system. Undermining the potential benefits are security threats, and those threats related to cyber security are described in this report. Concentrating on the design of the smart meter and its communication links, this report describes the ZigBee technology and implementation, and the communication between the smart meter and the collector node, with emphasis on security attributes. It was observed that many of the secure features are based on keys that must be maintained; therefore, secure key management techniques become the basis to securing the entire grid. The descriptions of current key management techniques are delineated, highlighting their weaknesses. Finally some initial research directions are outlined.
Chiropractic chronic low back pain sufferers and self-report assessment methods. Part II. A reliability study of the Middlesex Hospital Questionnaire and the VAS Disability Scales Questionnaire. (1989)

The subjective complaints of 41 chronic low back pain sufferers attending a chiropractic clinic were assessed twice prior to therapy with a widely used psychological self-report assessment tool, the Middlesex Hospital Questionnaire (MHQ) and a newly developed VAS Disability Scales Questionnaire (DISQ), both of which investigate various aspects of certain basic positions and activities. Reliability was generally acceptable with these two questionnaires. Subjects participating in the study were commonly found to score within the normal range on the MHQ, indicating that psychological disturbance was not a major feature of their presentation. However, mild mood disturbance was commonly reported, and a more sensitive tool may need to be developed for this type of mildly affected chronic low back pain sufferers. The DISQ generally indicated subjects were mildly to moderately affected by their low back trouble and that sitting and leisure activities were the most pain provoking. Recommendations for further development of the disability scale are made.
Neural networks for voiced/unvoiced speech classification (2002)

The results of designing, training, and testing a neural network for the voiced/unvoiced (V/UV) speech classification problem are described. A feedforward multilayer backpropagation network was used with six input, ten internal, and two output nodes-for a binary decision. The six features are common and easily computed. Training was done with 72 frames from two speakers. Testing was done with 479 frames from four speakers and resulted in a total of two errors (0.4%). Thus, a small neural network performs well on the V/UV problem.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A single flux quantum Josephson junction memory cell (1974)

Operation of a DRO single flux quantum Josephson junction memory cell is described. Writing and sensing is performed with coincident currents. The device acts as its own sense detector, switching to the gap voltage if a flux quantum was stored. Dense arrays not requiring standby power are potentially feasible.
Geo-location-aware emulations for performance evaluation of mobile applications (2014)

This paper presents the design of a simple emulation framework for performance evaluation and testing of mobile applications. Our testbed combines production hardware and software to allow emulation of realistic and repeatable mobility scenarios, in which the mobile user can travel long distances, while being served by an application server. The framework allows (i) geo-location information, (ii) client network conditions such as bandwidth and loss rate, as well as (iii) the application workload to be emulated synchronously. To illustrate the power of the framework we also present the design, proof-of-concept implementation, and evaluation of a geo-smart scheduler for application updates in smartphones. This geo-smart scheduler reduces the average download time by using a network performance map to schedule the downloads when at places with relatively good conditions. Our trace-driven evaluation of the geo-smart scheduler, illustrates the workings of the emulation framework, and the potential of the geo-smart scheduler.
Biological consequences of tumor hypoxia. (2001)

Growing evidence from experimental and clinical studies points to the fundamental, pathophysiologic role of hypoxia in solid tumors. Intratumoral hypoxia is a consequence of a structurally and functionally disturbed microcirculation, with deterioration of the diffusion geometry and of tumor-associated anemia. Hypoxia-induced changes of the proteome in the neoplastic and stroma cells may lead to neoplastic growth impairment through molecular mechanisms, resulting in cellular quiescence, differentiation, and apoptosis. Alternatively, hypoxia-induced proteome changes activating nonspecific stress response, anaerobic metabolism, angiogenesis, tissue remodeling, and change of cell contacts may promote tumor propagation by enabling neoplastic cells to overcome the nutritive deprivation through adaptation or escape from the "hostile" environment. Whether the phenotypic result of hypoxia-induced proteome change is impairment, stasis, or promotion of neoplastic growth is thought to be determined by the genome of the tumor cells and additional microenvironmental factors. Tumor cells with genomic alterations (such as loss of apoptotic potential) allowing their survival under hypoxia will aggravate tumor hypoxia. Sustained hypoxia increases genomic instability, genomic heterogeneity, and the selection pressure of the microenvironment. New variants even better adapted to survive and proliferate under reduced pO2 will be selected through clonal expansion. These variants will further drive the vicious circle of malignant progression which is clinically characterized by an increasing probability of local, perifocal, regional, and distant spread.