gebhart/patrepeval huggingface dataset:
Infection with HIV is associated with elevated IL-6 levels and production. (1990)

Polyclonal B cell activation is commonly observed in AIDS and in infection with HIV. Because IL-6 (B cell stimulatory factor 2) plays an essential role in the differentiation of activated B cells to Ig-secreting cells, and because IL-6 production is induced by exposure of human PBMC to HIV, we measured the level of circulating plasma IL-6, spontaneously-produced IL-6, and IL-6 mRNA in HIV-infected donors and in healthy control donors. Elevated levels of plasma IL-6 and IL-6 mRNA were detected in HIV-infected donors. PBMC isolated from the peripheral circulation of HIV-infected donors, and cultured without added exogenous activators of IL-6 production, produced markedly elevated amounts of IL-6 when compared with cells isolated from healthy donors. Interestingly, levels of an acute-phase protein, which is known to be induced by IL-6, was also increased in HIV-infected donors. These results demonstrate that elevated levels of IL-6 are associated with HIV-infection, and suggest that IL-6 over-production may contribute to the polyclonal B cell activation seen in AIDS and HIV infection.
Description of a dinucleotide repeat polymorphism in the human elastin gene and its use to confirm assignment of the gene to chromosome 7 (1993)

Informative polymorphisms have been very difficult to detect in the elastin gene, and this has hampered the analysis of heritable connective tissue disorders, notably the Marfan syndrome. We have recently detected a dinucleotide repeat polymorphism in intron 17 of the human elastin gene consisting of 8 alleles with sizes between 161 and 175 bp. Analysis of 540 chromosomes from unrelated Caucasian individuals revealed a bimodal frequency distribution typical of (dC-dA)n.(dG-dT)n repeat polymorphisms, with allele frequencies ranging from 0.004 (161 bp) to 0.574 (163 bp). As the elastin gene was originally assigned to chromosome 2q31-ter and because more recent data have suggested an assignment to 7q11.1-21.1, we have genotyped a sub-set of the CEPH pedigrees and carried out pairwise linkage analysis with markers on chromosomes 7 and 2. Lod-scores of between +3.70 and +13.69 were obtained with markers spanning 7p13-q22.1, whilst negative lod-scores were observed with the chromosome 2 markers. Analysis of type II human ovarian teratomas placed the elastin gene within 11 cM of the centromere on chromosome 7. Additionally, we detected the dinucleotide repeat in human-rodent cell hybrids containing chromosome 7, but not those containing chromosome 2. These data confirm the assignment of elastin to chromosome 7 and provide a new, highly informative marker for the analysis of heritable disorders of connective tissue for which elastin is a candidate gene.
EFFECT OF THIOL-COMPOUND ON TOXICITY OF HABU SNAKE (TRIMERESURUS FLAVOVIRIDIS HALLOWELL) VENOM (1971)

In the previous paper on the effects of various chelating agents on the systemic action of Habu snake venom, we reported that the treatment with EDTA enhanced the toxicity of the venom while thiol-compounds such as BAL and d-penicillamine markedly reduced it (1). In the present work three thiol-compounds, that is 1-cysteine, thioglycolate-Na and dihydrothioctic acid were examined for their effects on the systemic action of Habu snake venom.
Chain Transfer in the Polymerization of Styrene. V. Polymerization of Styrene in the Presence of Mercaptans (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChain Transfer in the Polymerization of Styrene. V. Polymerization of Styrene in the Presence of MercaptansR. A. Gregg, D. M. Alderman, and Frank R. MayoCite this: J. Am. Chem. Soc. 1948, 70, 11, 3740–3743Publication Date (Print):November 1, 1948Publication History Published online1 May 2002Published inissue 1 November 1948https://pubs.acs.org/doi/10.1021/ja01191a058https://doi.org/10.1021/ja01191a058research-articleACS PublicationsRequest reuse permissionsArticle Views507Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Replacement of All Arginine Residues with Canavanine in MazF-bs mRNA Interferase Changes Its Specificity (2013)

Replacement of a specific amino acid residue in a protein with nonnatural analogues is highly challenging because of their cellular toxicity. We demonstrate for the first time the replacement of all arginine (Arg) residues in a protein with canavanine (Can), a toxic Arg analogue. All Arg residues in the 5-base specific (UACAU) mRNA interferase from Bacillus subtilis (MazF-bs(arg)) were replaced with Can by using the single-protein production system in Escherichia coli. The resulting MazF-bs(can) gained a 6-base recognition sequence, UACAUA, for RNA cleavage instead of the 5-base sequence, UACAU, for MazF-bs(arg). Mass spectrometry analysis confirmed that all Arg residues were replaced with Can. The present system offers a novel approach to create new functional proteins by replacing a specific amino acid in a protein with its analogues.
Components of spore production in apple powdery mildew (Podosphaera leucotricha) (1986)

The morphology of powdery mildew ( Podosphaera leucotricha) colonies of known age was studied on six apple cultivars inoculated in a glasshouse. Colonies were observed first on the older leaves. Mean disease incidence ranged from about 20% for cv. Laxton's Superb to about 45% for cv. Crispin. Conidiophore density (number of conidiophores/mm 2 colony) was higher on younger than on older leaves, higher on the upper than on the lower leaf surface, and decreased with the age of the colony. The number of hyphal interceptions on a line transect was higher on the upper surface but the ratio of conidiophore density to hyphal interceptions was greater on the lower surface and did not differ with colony age or cultivar. The number of conidia/conidiophore was higher on the younger leaves and on the upper surfaces and was at a maximum 7‐12 days after the first sign of the colony. The number of conidia/mm 2 colony was higher on lower surfaces, especially of the younger leaves. There was generally an associated variation between cultivars in components of spore production.
Pulmonary embolism after hip or knee replacement: postoperative changes on pulmonary scintigrams in asymptomatic patients. (1989)

Serial pulmonary imaging has proved to be effective in the evaluation of patients undergoing total joint arthroplasty. A clinical dilemma arises in asymptomatic patients whose postoperative pulmonary images differ from the preoperative images. The authors prospectively evaluated 403 patients with serial imaging to determine the significance of changed postoperative images in asymptomatic patients undergoing total hip or knee arthroplasty. Twenty-two (5.5%) patients had significant changes on postoperative images. Seventeen were asymptomatic; all but one underwent pulmonary angiography. Documented pulmonary emboli were demonstrated in 100% of patients whose postoperative images changed to indicate a high probability of pulmonary embolism, 71% whose images changed to a moderate probability, and 0% whose images changed to indeterminate probability. Overall, pulmonary emboli occurred in 76% of all asymptomatic patients with significantly change postoperative images. Asymptomatic pulmonary embolism is a significant occurrence after total hip or knee repair, and a changed lung scan with appropriate clinical evaluation is an accurate indicator of pulmonary emboli in asymptomatic postarthroplasty patients.
A STUDY OF ENERGY TRANSFER PROCESSES IN MOLECULAR LASERS (1970)

Abstract : A study of energy transfer processes in molecular lasers is being carried out. The document is an interim report on progress to date accomplished under this grant.
Awakened apparel (2014)

Each morning we select an outfit meant to suit our mood and our plans. What if our clothes could seamlessly morph with us as our attitudes and activities change throughout the day? We created Awakened Apparel; one of the first shape-changing fashions to employ pneumatically actuated origami. Our prototype draws from diverse disciplines including soft robotics and fashion to present a design vision that advances the growing field of dynamic interactive garments. We explore technical and fabrication approaches for shape-changing technology held close to the body and identify areas for further innovation.
Oxidation of ethane by an Acremonium species (1976)

Ethane oxidation was studied in ethane-grown resting cells (mycelia) of an Acremonium sp. and in cell-free preparations of such mycelia. From resting cell experiments evidence was found for a pathway of ethane oxidation via ethanol, acetaldehyde, and acetic acid. In vitro studies indicated that ethane-oxidizing activity in such mycelia occurred predominantly in the microsomal fraction of crude homogenates. Microsomal preparations were inactive in the absence of added coenzyme. Marked stimulation of activity was obtained in such preparations with reduced nicotinamide adenine dinucleotide phosphate and to a much lesser degree with nicotinamide adenine dinucleotide phosphate. Ethane oxidation was inhibited by sodium azide and carbon monoxide.
Synthesis of 8-Fluoro-10-methyl-1,2-benzanthracene<sup>1</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 8-Fluoro-10-methyl-1,2-benzanthracene1MELVIN S. NEWMAN and EDWARD H. WISEMANCite this: J. Org. Chem. 1961, 26, 9, 3208–3211Publication Date (Print):September 1, 1961Publication History Published online1 May 2002Published inissue 1 September 1961https://pubs.acs.org/doi/10.1021/jo01067a042https://doi.org/10.1021/jo01067a042research-articleACS PublicationsRequest reuse permissionsArticle Views221Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
103rd meeting of the American Chemical Society. Division of Chemical Education. Memphis, Tennessee, April 20-24, 1942 (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT103rd meeting of the American Chemical Society. Division of Chemical Education. Memphis, Tennessee, April 20-24, 1942Paul H. Fall Cite this: J. Chem. Educ. 1942, 19, 6, 252Publication Date (Print):June 1, 1942Publication History Received3 August 2009Published online1 June 1942Published inissue 1 June 1942https://doi.org/10.1021/ed019p252.2Request reuse permissions Article Views14Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Other access optionsGet e-Alertsclose Get e-Alerts
New imaging systems in nuclear medicine. Technical progress report, July 1, 1974--April 1, 1975 (1975)

and oxygen utilization using /sup 15/O/sub 2/. Rubidium-82 also appears to be a promising agent for measurement of cerebral blood flow.
Collector-top GaAs/AlGaAs heterojunction bipolar transistors for high-speed digital ICs (1986)

GaAs/AlGaAs collector-top heterojunction bipolar transistors with magnesium and phosphorus double-implanted external bases were fabricated. A cutoff frequency of 17 GHz and a gate delay time of 63 ps for DCTL were obtained. These results indicate the potential of collector-top HBTs for high-speed ICs.
Sudden Aspen Decline Report for Spruce Beetle Epidemic and Aspen Decline Management Response EIS (2014)

Aspen is an important component of GMUG’s forests. Over 288,000 ha (712,000 acres) of aspendominated forest type (TAA) occur across the GMUG (Table 1). Just over half (55%) of the aspen forest type is outside wilderness and roadless areas.
A high-performance miniaturized time division multiplexed sensor system for remote structural health monitoring (2004)

We report for the first time the design, implementation and commercial application of a hand-held optical time division multiplexed, distributed fibre Bragg grating sensor system. A unique combination of state-of-the art electronic and optical components enables system miniaturization whilst maintaining exceptional performance. Supporting more than 100 low-cost sensors per channel, the battery-powered system operates remotely via a wireless GSM link, making it ideal for real-time structural health monitoring in harsh environments. Driven by highly configurable timing electronics, an off-the-shelf telecommunications semiconductor optical amplifier performs combined amplification and gating. This novel optical configuration boasts a spatial resolution of less than 20cm and an optical signal to noise ratio of better than 30dB, yet utilizes sensors with reflectivity of only a few percent and does not require RF speed signal processing devices. This paper highlights the performance and cost advantages of a system that utilizes TDM-style mass manufactured commodity FBGs. Created in continual lengths, these sensors reduce stock inventory, eradicate application-specific array design and simplify system installation and expansion. System analysis from commercial installations in oil exploration, wind energy and vibration measurement will be presented, with results showing kilohertz interrogation speed and microstrain resolution.
Design and Synthesis of Sensitive Fluorogenic Substrates Specific for Lys-Gingipain (2000)

Lys-gingipain (Kgp) is a major cysteine proteinase produced by the oral anaerobic bacterium Porphyromonas gingivalis, and has been implicated as a major pathogen in the development and progression of advanced adult periodontitis. This enzyme is believed to act as a major virulence factor of the disease, yet there exist no convenient and sensitive substrates for analyzing its biological activity. For a better understanding of the importance of this enzyme in the organism, there is an urgent need for specific substrates. Here we designed and synthesized two peptide 4-methyl-coumaryl-7-amides (MCA), carbobenzoxy (Z)-His-Glu-Lys-MCA, and Z-Glu-Lys-MCA, and tested their possible use as sensitive substrates for Kgp with limited specificity. Both substrates exhibited greater k(cat)/K(m) values than the best known Kgp substrates described so far. Both substrates were resistant to Arg-gingipain, another pathogenic cysteine proteinase from P. gingivalis, as well as trypsin and cathepsins B, L, and H. The levels of Kgp in various microorganisms and human cells were determined with Z-His-Glu-Lys-MCA. Little or no Kgp-like activity was detected in either other microorganisms or human cells tested. These results indicate that the present substrates are a valuable and fast tool for routine assays and for mechanistic studies on Kgp.
Preparation and characteristics of photocross‐linkable poly(vinyl alcohol) (1982)

Abstract The reaction of poly(vinyl alcohol) with styrylpyridinium and quinolinium salts which contain formyl group produced water‐soluble photosensitive polymers. The sensitivity was high, although the content of the styryl groups was extraordinarily low. Spectroscopical studies revealed that the high sensitivity is due to the aggregation of photofunctional group in the polymer matrix which leads to cyclodimerization on exposure to ultraviolet (UV) light.
Mechanical Properties of Poly(vinyl Chloride) Filled with Silica Particles (1999)

In general, the yield stress of a ductile polymer is decreased by incorporating filler particles. The effects of particle shape, size, content and changes in the adhesion of particle/matrix interfaces on the yield stress were investigated qualitatively in silica particle-filled poly(vinyl chloride). For this purpose, spherical and irregular-shaped silica particles having different mean sizes, ranging from 2 - 50 μm, were incorporated. The particle contents were 6 and 16% by volume. In the untreated silica-filled resins, the yield stress decreased with increasing particle content and size. The yield stress was higher in the irregular-shaped than in the spherical particle silica-filled resins. The particles were treated with γ-aminopropyl methyldiethoxysilane as a silane coupling agent to improve the adhesion of the particle/matrix interfaces. The yield stress was increased by the treatment and the tendency was more noticeable in the irregular-shaped than in the spherical systems. That is, the yield stresses of the treated irregular-shaped silica systems were higher than that of unfilled poly(vinyl chloride) and they were independent of particle content within the measured range. It was confirmed that the yield stress of the particle-filled composite was affected by the above factors and the importance of particle shape and the adhesion of particle/matrix interface were particularly noteworthy.
Modeling and Analysis of Erosion and Redeposition For Limiter and Divertor Impurity Control Systems (1983)

Erosion and redeposition of sputtered material from a limiter and divertor were analyzed using the REDEP computer code. Both low- and high-Z materials were examined for a wide range of plasma edge temperatures. Redeposition rates are high in most cases, and net erosion rates are predicted to be much smaller than the gross rates. The limiter front face and the entire divertor plate have similar erosion properties. The lifetime of both surfaces depends critically on the redeposition process; under certain conditions relatively long lifetimes may be obtainable.
Digital Image Watermark Algorithm Based on Wavelet Transform and Compound Chaotic System (2010)

In this paper,a digital image watermark algorithm based on wavelet transform and compound chaotic system is presented.During the embedding of the watermarking,discrete wavelet transform is done firstly and low frequency part is extracted as the embedding field.Secondly,there is a measure to encrypt the watermark by using the compound chaotic sequence,and then we transform the encrypted part and extract the low frequency.Finally,we embed the low frequency part into the original image.This paper mentions a method to evaluate the algorithm by the similar coefficient NC and peak noise to signal ration PSNR.The experiment result shows that the algorithm can resist JPEG compression,noise attack,filter and so on.The effect of watermark image is quite obvious.
A 10-b 800MS/s time-interleaved SAR ADC with fast timing-skew calibration (2016)

This paper presents a time-interleaved (TI) successive-approximation-register (SAR) ADC with a fast variance-based timing-skew calibration technique. It uses a single comparator-based window detector to calibrate the timing skew. It has low-hardware cost and 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> times faster convergence speed compared to prior variance-based timing skew calibration technique. The proposed technique brings collateral benefits of offset mismatch calibration. A prototype 10-b 800MS/s ADC in 40nm CMOS achieves Nyquist-rate SNDR of 48 dB and consumes 9.8mW, leading to a Walden FoM of 59-fJ/conversion-step.
Immersive audio for the desktop (2002)

Integrated media workstations are increasingly being used for creating, editing, and monitoring sound that is associated with video or computer-generated images. While the requirements for high quality reproduction in large-scale systems are well understood, these have not yet been adequately translated to the workstation environment. We discuss several factors that pertain to high quality sound reproduction at the desktop including acoustical considerations, signal processing requirements, and listener location issues. We also present a novel desktop system design with integrated listener-tracking capability that circumvents several of the problems faced by current digital audio and video workstations.
Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation (2017)

It is well known that cereblon is a key protein in autosomal recessive nonsyndromic mental retardation. Studies have reported that it has an intermediary role in helping immunomodulatory drugs perform their immunomodulatory and tumoricidal effects. In addition, cereblon also regulates the expression, assembly, and activities of other special proteins related to cell proliferation and metabolism, resulting in the occurrence and development of metabolic diseases. This review details the multiple functions of cereblon and the underlying mechanisms. We also put forward some unsolved problems, including the intrinsic mechanism of cereblon function and the possible regulatory mechanisms of its expression.
Role of apoptosis and transforming growth factor β1 in fibroblast selection and activation in systemic sclerosis (2000)

Our results show that resistance to apoptosis is an important part of the SSc phenotype. TGFbeta1 may play a role by inducing apoptosis-resistant fibroblast populations, and also by inducing myofibroblasts and by enhancing extracellular matrix synthesis.