gebhart/patrepeval huggingface dataset:
Investigating applications portability with the Uintah DAG-based runtime system on PetaScale supercomputers (2013)

Present trends in high performance computing present formidable challenges for applications code using multicore nodes possibly with accelerators and/or co-processors and reduced memory while still attaining scalability. Software frameworks that execute machine-independent applications code using a runtime system that shields users from architectural complexities offer a possible solution. The Uintah framework for example, solves a broad class of large-scale problems on structured adaptive grids using fluid-flow solvers coupled with particle-based solids methods. Uintah executes directed acyclic graphs of computational tasks with a scalable asynchronous and dynamic runtime system for CPU cores and/or accelerators/co-processors on a node. Uintah's clear separation between application and runtime code has led to scalability increases of 1000x without significant changes to application code. This methodology is tested on three leading Top500 machines; OLCF Titan, TACC Stampede and ALCF Mira using three diverse and challenging applications problems. This investigation of scalability with regard to the different processors and communications performance leads to the overall conclusion that the adaptive DAG-based approach provides a very powerful abstraction for solving challenging multi-scale multi-physics engineering problems on some of the largest and most powerful computers available today.
Sensor linearization with neural networks (2001)

A procedure for extending the linear range of an arbitrary sensor is proposed. The process is carried out by a neural network which compensates the sensor nonlinear characteristic. A negative temperature coefficient resistor sensor is used as an application example of the procedure, and its implementation in low-resolution microcontrollers is analyzed.
Pyrene Excimer‐Based Dual‐Emission Detection of a Oligoaspartate Tag‐Fused Protein by Using a Zn<sup>II</sup>–DpaTyr Probe (2007)

A dual-emission sensing system for proteins tethered to a repeated tetra-aspartate tag (D4-tag) was successfully developed by using the binding-induced excimer formation of the pyrene-appended ZnII–DpaTyr probe. This allows selective detection of the D4-tag-fused protein in a simple and convenient manner by the naked eye. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2007/z700146_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Characteristics of ion-beam-sputtered thin films (1979)

Thin films of Au, Si, Al, NiFe, Ta, and W have been prepared by ion beam sputtering, and physical properties have been compared with films deposited by rf sputtering, and electron beam evaporation. In general, films of a given material appeared to be comparable for the properties measured, independent of deposition method. In the ion beam sputtering system, the effects of deposition rates are studied as a function of the accelerating voltage of the ion beam, and of the angle created by the target tilt and the path of the ion beam. Deposition rates generally leveled off at an accelerating voltage of 750 V; and for several materials, a peak in deposition rate was observed at a target-beam angle of 30°. The magnetic properties of ion-beam-sputtered NiFe films are compared before and after annealing in vacuum at 350°C for 30 minutes. Annealing produced a small drop in the resistivity of these films, with a corresponding increase in the magnetoresistive effect, Δρ/ρ. Electron microprobe measurements indicate no significant incorporation of ionizing gas in the films. Ion-beam-sputtered thin films appear to be as good as films deposited by the other techniques discussed, and have shown a distinct advantage for use in liftoff processes. Since ion beam deposition occurs in a field-free region, heating effects due to electron bombardment of the substrate are minimal. Photoresist images are not degraded, and subsequent lift-off is facilitated.
Transfer of cholesterol from macrophages to lymphocytes in culture (1998)

A major feature of macrophage metabolism is its capacity to produce and export cholesterol. Several reports have shown that the manipulation of lymphocyte cholesterol content elicits important changes in lymphocyte proliferation. These findings lead to an inquiry as to whether macrophage-derived cholesterol released into the lymphocyte surroundings may be transferred to the latter thus affecting lymphocyte function. In this study, cholesterol transfer from macrophages to lymphocytes was examined in vitro using rat cells in culture. The findings indicate that there may be a significant transfer of cholesterol from [4-14C]cholesterol labeled resident peritoneal macrophages to mesenteric lymph node resting lymphocytes (up to 173.9 +/- 2.7 pmol/10(7) lymphocytes/10(7) macrophages when co-cultivated for 48 h), in a lipoprotein-dependent manner. This represents the mass transfer of ca. 17 nmoles of cholesterol molecules per 10(7) lymphocytes from 10(7) macrophages (calculated on the basis of specific radioactivity incorporated into macrophages after the pre-labelling period), which suggests that macrophages are capable of replacing the whole lymphocyte cholesterol pool every 21 h. Moreover, an 111%-increase in the total cholesterol content of lymphocytes was found after co-cultivation with macrophages for 48 h. When compared to peritoneal cells, monocytes/macrophages obtained from circulating blood leukocytes presented a much higher cholesterol transfer capacity to lymphocytes (3.06 +/- 0.10 nmol/10(7) lymphocytes/10(7) macrophages co-cultivated for 24 h). Interestingly, inflammatory macrophages dramatically reduced their cholesterol transfer ability (by up to 91%, as compared to resident macrophages). Cholesterol transfer may involve a humoral influence, since it is not only observed when cells are co-cultivated in a single-well chamber system (cells in direct contact), but also in a two-compartment system (where cells can communicate but not by direct contact). Co-cultivation with macrophages decreased the basal incorporation of [2-14C]thymidine into lymphocyte DNA and the addition of cholesterol to lymphocyte culture media also impaired the lymphocyte proliferative response to the mitogens concanavalin A (Con A) and bacterial lipopolysaccharide (LPS). The above results suggest that macrophages may transfer cholesterol to lymphocytes (from both lymph nodes and blood), thus regulating lymphocyte function by raising the intracellular cholesterol content and suppressing lymphocyte proliferative activity. If this is so, a modulatory role for the transfer of cholesterol in both physiological (e.g. immune response) and pathological conditions (e.g. atherosclerosis) may be postulated. This hypothesis is currently under investigation in our laboratory.
Cost-efficient architecture of IPsec classification engine with TCAM (2017)

This paper presents an IPsec Protocol Processing Engine with TCAM Optimized for cost and performance multiple packet classification and filtering on the next generation IP networks. The proposed architecture can accelerate the process of IP layer security protocol, by using common TCAM architecture shared for inbound and outbound packet filters. It can substantially reduce the size of TCAM, while maintaining the speed of the searching and matching process. The proposed IPsec classification engine has been implemented in an NS-3 simulator for functional verification, and also in Verilog for performance and cost analysis. We demonstrate that the proposed architecture can reduce the TCAM by 60% compared with conventional individual TCAM architecture. In addition, the proposed architecture can speed up the classification process by 15 times over software based IPsec classification.
Design of a CMOS oscillator with magnetic-field frequency modulation (1987)

A magnetosensitive n-channel split-drain MOSFET (MAGFET) integrated with a current-controlled oscillator on a single chip is described. This magnetically controlled oscillator (MCO), which was fabricated in 5-/spl mu/m CMOS technology, is sensitive to magnetic fields perpendicular to the chip surface. The output of the MCO is a square wave whose frequency varies linearly with, and is modulated by, the magnetic input signal.
Ambiguity in Tempo Perception: What Draws Listeners to Different Metrical Levels? (2006)

The distribution of listeners’ perceived tempi across large collections of music has been modeled previously by a resonance function with a peak near the “preferred tempo” of 120 beats per minute (BPM) [Van Noorden and Moelants, J. New Music Res., 28, 43–66]. Here, through a series of experiments in which listeners were asked to tap to the most salient pulse of musical excerpts,we examined distributions of tapped tempi from single musical excerpts to see if the global resonance of preferred tempo is dependent on musical content. Results show that for some musical excerpts, the distribution of perceived tempi conforms to the global resonant form in that metrical levels with tempi near 120 BPM were perceived as most salient, while for other excerpts the most saliently perceived tempo sat well above or below 120 BPM. We then used a model, which quantifies relative strengths of periodicities in the audio signal, to demonstrate that deviations from the “preferred tempo” can be partially explained by dynamic rhythmic accents drawing listeners to tempi away from the resonance.
Group matching of interacting light pulses in nonlinear crystals (1975)

Conditions are found for the simultaneous phase and group matching in three-photon parametric interaction between ultrashort light packets in KDP, LiNbO3, and LiIO3 crystals.
Long-Term Safety of Spironolactone in Acne: Results of an 8-Year Followup Study (2002)

After 200 person-years of exposure to spironolactone and 506 person-years of followup over 8 years, no serious illnesses thought to be attributed to spironolactone were reported. The long-term use of spironolactone in the treatment of acne in women appears to be safe. Side effects, however, are common, although not usually a cause for stopping the drug.
Bi-phasic Reactions in Microreactors (2008)

The contact between immiscible liquids in a microfluidic system creating segmented flow offers great potential in the study of biphasic reactions in organic chemistry with significant advantages with respect to conventional flask techniques. As organic solvents play a key role in many chemical processes within the pharmaceutical and chemical industry, there are many applications of biphasic reactions in different areas of chemistry. For a simple biphasic reactions, we show that the application of various reaction conditions in microreactors using segmented flow can dramatically increase the reaction rate, especially when microwave irradiation, sonication or phase transfer catalysis are combined with segmentation.
Efficient Single Photon Detection from 500 nm to 5 μm Wavelength (2012)

We report on superconducting nanowire single photon detectors (SNSPDs) based on 30 nm wide nanowires with detection efficiency η ∼ 2.6-5.5% in the wavelength range λ = 0.5-5 μm. We compared the sensitivity of 30 nm wide SNSPDs with the sensitivity of SNSPDs based on wider (85 and 50 nm wide) nanowires for λ = 0.5-5 μm. The detection efficiency of the detectors based on the wider nanowires became negligible at shorter wavelengths than the 30 nm wide SNSPDs. Our 30 nm wide SNSPDs showed 2 orders of magnitude higher detection efficiency (η ∼ 2%) up to longer wavelength (λ = 5 μm) than previously reported. On the basis of our simulations, we expect that by changing the optical coupling scheme and by integrating the detectors in an optical cavity, the detection efficiency of our detectors could be increased by a factor of ∼6.
Anogenital Warts in Children (1990)

Seventy-three children with anogenital warts were examined for sexual abuse during a 2-year period. Our data suggest that nonsexual transmission is common, particularly in children under 3 years of age. Approximately 25% of these children were younger than age 1 year, and another 50% were between the ages of 1 and 3 years. No evidence of sexual abuse was detected in 66 children.
Site-Specific Proteolytic Cleavage of the Amino Terminus of Herpes Simplex Virus Glycoprotein K on Virion Particles Inhibits Virus Entry (2011)

Herpes simplex virus 1 (HSV-1) glycoprotein K (gK) is expressed on virions and functions in entry, inasmuch as HSV-1(KOS) virions devoid of gK enter cells substantially slower than is the case for the parental KOS virus (T. P. Foster, G. V. Rybachuk, and K. G. Kousoulas, J. Virol. 75:12431-12438, 2001). Deletion of the amino-terminal 68-amino-acid (aa) portion of gK caused a reduction in efficiency and kinetics of virus entry similar to that of the gK-null virus in comparison to the HSV-1(F) parental virus. The UL20 membrane protein and gK were readily detected on double-gradient-purified virion preparations. Immuno-electron microscopy confirmed the presence of gK and UL20 on purified virions. Coimmunoprecipitation experiments using purified virions revealed that gK interacted with UL20, as has been shown in virus-infected cells (T. P. Foster, V. N. Chouljenko, and K. G. Kousoulas, J. Virol. 82:6310-6323, 2008). Scanning of the HSV-1(F) viral genome revealed the presence of a single putative tobacco etch virus (TEV) protease site within gD, while additional TEV predicted sites were found within the UL5 (helicase-primase helicase subunit), UL23 (thymidine kinase), UL25 (DNA packaging tegument protein), and UL52 (helicase-primase primase subunit) proteins. The recombinant virus gDΔTEV was engineered to eliminate the single predicted gD TEV protease site without appreciably affecting its replication characteristics. The mutant virus gK-V5-TEV was subsequently constructed by insertion of a gene sequence encoding a V5 epitope tag in frame with the TEV protease site immediately after gK amino acid 68. The gK-V5-TEV, R-gK-V5-TEV (revertant virus), and gDΔTEV viruses exhibited similar plaque morphologies and replication characteristics. Treatment of the gK-V5-TEV virions with TEV protease caused approximately 32 to 34% reduction of virus entry, while treatment of gDΔTEV virions caused slightly increased virus entry. These results provide direct evidence that the gK and UL20 proteins, which are genetically and functionally linked to gB-mediated virus-induced cell fusion, are structural components of virions and function in virus entry. Site-specific cleavage of viral glycoproteins on mature and fully infectious virions utilizing unique protease sites may serve as a generalizable method of uncoupling the roles of viral glycoproteins in virus entry and virion assembly.
General and physical chemistry (1917)

H. M. Dawson, Annu. Rep. Prog. Chem., 1917, 14, 1 DOI: 10.1039/AR9171400001
Advances in Research in Animal Models of Burn-Related Hypertrophic Scarring (2014)

Skin burn injuries affect approximately 500,000 people per year in France. After deep burns, functional sequelae associated with hypertrophic and retractile scars are an important public health problem. To understand the pathophysiology of sequelae and evaluate new therapeutic approaches, the use of animal models that should be standard tools is necessary. Some pre-clinical models of hypertrophic scars after burns have been described, but the choice of the appropriate and relevant experimental model is crucial to accurately investigate any therapeutic approach. A variety of hypertrophic scar animal models have been described after burn lesions; none of which being totally satisfactory. The most frequently used is the hypertrophic scar model after skin excision of the ear rabbit, but this model does not reflect burn injuries. The red Duroc pig seems to be the more relevant model of human hypertrophic scarring after burns; however, because of costs and the lack of studies evaluating burn injuries in this species, the domestic pig is most commonly used in burn research. Elevated hypertrophic scars are obtained, but they spontaneously resolve within a year. Although mortality in small animals is higher and creates technical difficulties, many models on nude mice are used in research. Indeed, transplantation of human hypertrophic scar tissue or human skin grafts may induce hypertrophic scarring that can last more than a year permitting additional manipulation and experimentation.
Human embryonic stem cell-derived mesenchymal stem cells as a therapy for spinal cord injury (2014)

Traumatic injury to the spinal cord interrupts ascending and descending
pathways leading to severe functional deficits of sensory motor and autonomic
function which depend on the level and severity of the injury. There are
currently no effective therapies for treating such injuries and the adult central
nervous system has very limited capacity for repair so that recovery is very
limited and functional deficits are usually permanent. Cell transplantation is a
potential therapy for spinal cord injury and a range of cell types are being
investigated as candidates. Mesenchymal stem cells (MSCs) obtained from bone
marrow are one cell type quite extensively studied. When transplanted into
animal models of spinal cord injury these cells are reported to affect various
aspects of repair and in some cases to improve functional outcome according to
behavioural measures. However, the use of these cells has several limitations
including the need for an invasive harvesting procedure, variability in cell
quality and slow expansion in culture. This project therefore had two main aims:
Firstly to investigate whether MSC-like cells closely equivalent to bone marrow
derived MSCs could be reliably and consistently differentiated from human
embryonic stem cells (hESCs) in order to provide an “off the shelf” cellular
therapy product for spinal cord injury and secondly, to transplant such cells into
animal models of spinal cord injury in order to, determine whether hESC-derived
MSCs replicate or improve on the repair mechanisms reported for bone marrow
MSCs.
YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias (2017)

Our results unequivocally demonstrate that in neurodegenerative dementias, YKL-40 is a disease-specific marker of neuroinflammation showing its highest levels in prion diseases. Therefore, YKL-40 quantification might have a potential for application in the evaluation of therapeutic intervention in dementias with a neuroinflammatory component.
Computing the Average Symbol Error Probability of the MPSK System Having Quadrature Error (2006)

ABSTRACTWhen quadrature error exists, the shape of the M-ary phase shift keying (MPSK) signal constellation becomes skewed-elliptic. Each MPSK symbol takes on a different symbol error probability (SEP) value. The analytical results presented thus far have been derived from studies which examined the SEP problem assuming that the SEP of each MPSK symbol is equally likely; therefore, those results should not be treated as offering a complete solution. In this letter, we present a new and more complete solution to the SEP problem of MPSK by relaxing the above assumption and finding the expressions for the average as well as individual SEP in the presence of quadrature error.
Survivability in a new pan-European carriers' carrier network based on WDM and SDH technology: current implementation and future requirements (1999)

A pan-European carriers' carrier network, like other carrier networks, must cope with the enormous traffic inflation by introducing appropriate network solutions. WDM technology is the solution adopted by GTS Carrier Services' Trans European Network unit (TEN, formerly known as Hermes Europe Railtel), driven by bandwidth requirements, infrastructure limitations, flexibility, and cost. The introduction of such new technology presents specific technical issues, although it lays the foundation of future optical networking. Network outages are an important concern since, by using WDM, tens of gigabits of data are transported on each fiber. On one hand, traffic interruption is avoided as much as possible through secure fiber routings, cable protection, high design and equipment standards, and security. On the other hand, network protection techniques are used to limit the impact on services when inevitable outages occur. We explain the role of the different technologies in TEN's network. We concentrate on WDM and optical networking where optical channels are used to interconnect the equipment used by the different technologies. We focus on optical network protection techniques and illustrate that a clear requirement exists for this. We also emphasize interworking issues that come into play when multiple technologies are combined in the same network. It is not the intent to discuss only future requirements, but also to explain how the different aspects are currently implemented in TEN's operational network.
CYANOALKOXYSILANES (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCYANOALKOXYSILANESKURT C. FRISCH and MILTON WOLFCite this: J. Org. Chem. 1953, 18, 6, 657–660Publication Date (Print):June 1, 1953Publication History Published online1 May 2002Published inissue 1 June 1953https://pubs.acs.org/doi/10.1021/jo01134a007https://doi.org/10.1021/jo01134a007research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts