gebhart/patrepeval huggingface dataset:
Torcetrapib Induces Aldosterone and Cortisol Production by an Intracellular Calcium-Mediated Mechanism Independently of Cholesteryl Ester Transfer Protein Inhibition (2009)

ILLUMINATE (Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events), the phase 3 morbidity and mortality trial of torcetrapib, a cholesteryl ester transfer protein (CETP) inhibitor, identified previously undescribed changes in plasma levels of potassium, sodium, bicarbonate, and aldosterone. A key question after this trial is whether the failure of torcetrapib was a result of CETP inhibition or of some other pharmacology of the molecule. The direct effects of torcetrapib and related molecules on adrenal steroid production were assessed in cell culture using the H295R as well as the newly developed HAC15 human adrenal carcinoma cell lines. Torcetrapib induced the synthesis of both aldosterone and cortisol in these two in vitro cell systems. Analysis of steroidogenic gene expression indicated that torcetrapib significantly induced the expression of CYP11B2 and CYP11B1, two enzymes in the last step of aldosterone and cortisol biosynthesis pathway, respectively. Transcription profiling indicated that torcetrapib and angiotensin II share overlapping pathways in regulating adrenal steroid biosynthesis. Hormone-induced steroid production is mainly mediated by two messengers, calcium and cAMP. An increase of intracellular calcium was observed after torcetrapib treatment, whereas cAMP was unchanged. Consistent with intracellular calcium being the key mediator of torcetrapib's effect in adrenal cells, calcium channel blockers completely blocked torcetrapib-induced corticoid release and calcium increase. A series of compounds structurally related to torcetrapib as well as structurally distinct compounds were profiled. The results indicate that the pressor and adrenal effects observed with torcetrapib and related molecules are independent of CETP inhibition.
Transition-metal-catalyzed asymmetric organic synthesis via polymer-attached optically active phosphine ligands. 4. Asymmetric hydroformylation (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransition-metal-catalyzed asymmetric organic synthesis via polymer-attached optically active phosphine ligands. 4. Asymmetric hydroformylationS. J. Fritschel, J. J. H. Ackerman, T. Keyser, and J. K. StilleCite this: J. Org. Chem. 1979, 44, 18, 3152–3157Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/jo01332a013https://doi.org/10.1021/jo01332a013research-articleACS PublicationsRequest reuse permissionsArticle Views165Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Multiplex Real-Time PCR Targeting the RNase P RNA Gene for Detection and Identification of <i>Candida</i> Species in Blood (2007)

We have developed a single-tube multiplex real-time PCR method for the detection of the eight most common Candida species causing septicemia: Candida albicans, C. dubliniensis, C. famata, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis, and C. tropicalis. The method developed targets the RNase P RNA gene RPR1. Sequences of this gene were determined for seven of the Candida species and showed surprisingly large sequence variation. C. glabrata was found to have a gene that was five times longer gene than those of the other species, and the nucleotide sequence similarity between C. krusei and C. albicans was as low as 55%. The multiplex PCR contained three probes that enabled the specific detection of C. albicans, C. glabrata, and C. krusei and a fourth probe that allowed the general detection of the remaining species. The method was able to detect 1 to 10 genome copies when the detection limit was tested repeatedly for the four species C. albicans, C. glabrata, C. krusei, and C. guilliermondii. No significant difference in the detection limit was seen when the multiplex format was compared with single-species PCR, i.e., two primers and one probe. The method detected eight clinically relevant Candida species and did not react with other tested non-Candida species or human DNA. The assay was applied to 20 blood samples from nine patients and showed a sensitivity similar to that of culture.
An Analysis of Peristaltic Locomotion for Maximizing Velocity or Minimizing Cost of Transport of Earthworm-Like Robots (2020)

Earthworm-like peristaltic locomotion has been implemented in >50 robots, with many potential applications in otherwise inaccessible terrain. Design guidelines for peristaltic locomotion have come from observations of biology, but robots have empirically explored different structures, actuators, and control waveform shapes than those observed in biological organisms. In this study, we suggest a template analysis based on simplified segments undergoing beam deformations. This analysis enables calculation of the minimum power required by the structure for locomotion and maximum speed of locomotion. Thus, design relationships are shown that apply to peristaltic robots and potentially to earthworms. Specifically, although speed is maximized by moving as many segments as possible, cost of transport (COT) is optimized by moving fewer segments. Furthermore, either soft or relatively stiff segments are possible, but the anisotropy of the stiffnesses is important. Experimentally, we show on our earthworm robot that this method predicts which control waveforms (equivalent to different gaits) correspond to least input power or to maximum velocity. We extend our analysis to 150 segments (similar to that of earthworms) to show that reducing COT is an alternate explanation for why earthworms have so few moving segments. The mathematical relationships developed here between structural properties, actuation power, and waveform shape will enable the design of future robots with more segments and limited onboard power.
Effect of H on Si molecular-beam epitaxy (1993)

In Si crystal growth by molecular-beam epitaxy (MBE) at low temperatures there is known to be an epitaxial thickness: an initially crystalline regime before the deposited film becomes amorphous. The predominant impurity in MBE is hydrogen, but the role of background H in low-temperature MBE has not previously been assessed. Here the effect of deliberate dosing of the Si surface with atomic H during low-T growth is studied. The epitaxial thickness is shown to be sensitive to very small additional H fluxes (≊10−9 Torr, i.e., an increase in H only marginally above ambient). With further increases in dose rate, the epitaxial thickness decreases as hepi=h0−k(ln PH). Using secondary-ion-mass spectrometry data on the segregated H at the interface, we argue that breakdown in epitaxy is not caused directly by the surface concentration of adsorbed impurities. It is deduced that very small concentrations of H may influence the Si surface diffusion rate. The possible effect of background H adsorption on previous experiments on Si steps and surface diffusion is discussed.
Liquid Crystalline 1,3-Disubstituted Cyclopentanes (1990)

Abstract Novel liquid crystalline 1,3-disubstituted cyclopentanes were studied for physicochemical and temperature characteristics.
Collaborative Workflow Management for eGovernment (2007)

eGovernment has become reality: Most governmental organisations offer electronic services to citizens through the Internet. However, inter-organizational collaboration, especially by means of workflows, is not as widespread. To foster transparency and control in collaborative workflows according to global policies, such as European law regulations, collaborative partners have to partially provide insight into local events and workflows to comply to the global regulations. An example collaboration between Eurojust and Europol emphasises the shortage of existing collaboration architectures lacking the desired control and transparency capabilities needed for the application domain of human-centric eGovernment workflows. To address this, we propose an architecture of a modular runtime infrastructure for decentralized, collaborative eGovernment workflows, hereby respecting the heterogeneity of the system and application landscapes in place.
Agreement Is Poor Among Current Criteria Used to Define Response to Cardiac Resynchronization Therapy (2010)

The 26 most-cited publications on predicting response to cardiac resynchronization therapy define response using 17 different criteria. Agreement between different methods to define response to cardiac resynchronization therapy is poor 75% of the time and strong only 4% of the time, which severely limits the ability to generalize results over multiple studies.
Dermal Absorption of Camphor, Menthol, and Methyl Salicylate in Humans (2004)

Camphor, menthol, and methyl salicylate occur in numerous over-the-counter products. Although extensively used, there have been no estimates of human exposure following administration via dermal application. Furthermore, there is little information about the pharmacokinetics of those compounds. The authors report the plasma concentrations of the intact compounds as a function of dose following dermal patch application. Three groups of 8 subjects (4 male, 4 female) applied a different number of commercial patches (2, 4, or 8) to the skin for 8 hours. Plasma samples were assayed using sensitive and selective gas-chromatographic methods. For the 8-patch group, the average maximum plasma concentrations (Cmax +/- SD) were 41.0 +/- 5.8 ng/mL, 31.9 +/- 8.8 ng/mL, and 29.5 +/- 10.5 ng/mL for camphor, menthol, and methyl salicylate, respectively. The corresponding values for the 4-patch group were 26.8 +/- 7.2 ng/mL, 19.0 +/- 5.4 ng/mL, and 16.8 +/- 6.8 ng/mL. The harmonic mean terminal half-lives were 5.6 +/- 1.3 hours, 4.7 +/- 1.6 hours, and 3.0 +/- 1.2 hours for camphor, menthol, and methyl salicylate, respectively. The 2-patch group had measurable but low plasma concentrations of each compound. Low-dose dermal application for an extended time results in low plasma concentrations of all 3 compounds. Four and 8 patches, when applied for 8 hours, gave measurable and nearly proportional plasma concentrations. Although unable to determine the absolute dermal bioavailability of these compounds, there appears to be relatively low systemic exposure to these potentially toxic compounds, even when an unrealistically large number of patches are applied for an unusually long time.
Reduction of Chemical Formulas from the Isotopic Peak Distributions of High-Resolution Mass Spectra (2003)

A method has been developed for the reduction of the chemical formulas of compounds in complex mixtures from the isotopic peak distributions of high-resolution mass spectra. The method is based on the principle that the observed isotopic peak distribution of a mixture of compounds is a linear combination of the isotopic peak distributions of the individual compounds in the mixture. All possible chemical formulas that meet specific criteria (e.g., type and number of atoms in structure, limits of unsaturation, etc.) are enumerated, and theoretical isotopic peak distributions are generated for each formula. The relative amount of each formula is obtained from the accurately measured isotopic peak distribution and the calculated isotopic peak distributions of all candidate formulas. The formulas of compounds in simple spectra, where peak components are fully resolved, are rapidly determined by direct comparison of the calculated and experimental isotopic peak distributions. The singular value decomposition linear algebra method is used to determine the contributions of compounds in complex spectra containing unresolved peak components. The principles of the approach and typical application examples are presented. The method is most useful for the characterization of complex spectra containing partially resolved peaks and structures with multiisotopic elements.
Mechanical Strength of Hemispheric Domes of Yttria and Lanthana‐Doped Yttria (1992)

The strength of hemispheric ceramic domes was measured in a biaxial flexure test using disklike circular pieces removed with a core drill. Yttria and lanthana‐doped yttria dome cores exhibit approximately 60% of the strength predicted from similarly fabricated flat disks. Measured strengths agree with those predicted from observed fracture‐initiating defects.
Peptidome Analysis of Cerebrospinal Fluid by LC-MALDI MS (2012)

We report on the analysis of endogenous peptides in cerebrospinal fluid (CSF) by mass spectrometry. A method was developed for preparation of peptide extracts from CSF. Analysis of the extracts by offline LC-MALDI MS resulted in the detection of 3,000-4,000 peptide-like features. Out of these, 730 peptides were identified by MS/MS. The majority of these peptides have not been previously reported in CSF. The identified peptides were found to originate from 104 proteins, of which several have been reported to be involved in different disorders of the central nervous system. These results support the notion that CSF peptidomics may be viable complement to proteomics in the search of biomarkers of CNS disorders.
Characterization of ornithine decarboxylase of tobacco cells and tomato ovaries. (1982)

Some characteristics of L-ornithine decarboxylase of tomato ovaries and tobacco cells are described. The enzyme has a pH optimum of 8.0. It requires pyridoxal phosphate and thiol reagent (dithiothreitol) for activity. It is specific for L-ornithine and has an apparent Km of 1.4 X 10-4 M. It has an apparent molecular weight of 107000. Putrescine inhibited the activity in vitro. Spermidine and spermine also inhibit the enzyme, but less effectively. It is concluded that the enzyme is similar to that of mammalian origin and likewise fulfils a function related to cell proliferation.
PAD4 Functions Upstream from Salicylic Acid to Control Defense Responses in Arabidopsis (1998)

Nan Zhou, Tina L. Tootle, Frank Tsui, Daniel F. Klessig, Jane Glazebrook, PAD4 Functions Upstream from Salicylic Acid to Control Defense Responses in Arabidopsis, The Plant Cell, Vol. 10, No. 6 (Jun., 1998), pp. 1021-1030
Power monitoring devices: trends in power automation (2002)

The issues and concerns related to power quality, safety, cost of energy and associated capital equipment are starting to be questioned as industry prepares itself for the 21st century and competitive global manufacturing. The author sets out to identify those areas of concern and discusses new trends that are developing, trends that apply new technology to traditional mature electromechanical power equipment. The benefits that can be achieved through power automation products are explained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The dark sides of amyloid in Alzheimer's disease pathogenesis (2014)

Although widely explored, the pathogenesis of Alzheimer's disease (AD) has yet to be cleared. Over the past twenty years the so call amyloid cascade hypothesis represented the main research paradigm in AD pathogenesis. In spite of its large consensus, the proposed role of β-amyloid (Aβ) remain to be elucidated. Many evidences are starting to cast doubt on Aβ as the primary causative factor in AD. For instance, Aβ is deposited in the brain following many different kinds of injury. Also, concentration of Aβ needed to induce toxicity in vitro are never reached in vivo. In this review we propose an amyloid-independent interpretation of several AD pathogenic features, such as synaptic plasticity, endo-lysosomal trafficking, cell cycle regulation and neuronal survival.
Gas-Crossover and Membrane-Pinhole Effects in Polymer-Electrolyte Fuel Cells (2008)

This paper investigates the effects of gas crossover. Specifically, mathematical simulations are conducted to elucidate the fundamental changes in fuel-cell operation as permeation of the various gases through the membrane increases. Two cases are explored, with the first one examining uniform increases in the set of gas-permeation coefficients, and the second one the existence of regions of high gas crossover (i.e., membrane pinholes). For the first case, operation at 120 C is studied and a maximum limit for the hydrogen permeation coefficient of 1 x 10{sup -10} mol/bar-cm-s for a 25 {micro}m membrane is determined. For the second case, it is shown that negative current densities and temperature spikes can arise due to mixed-potential and direct-combustion effects where there are large enough pinholes, thereby impacting performance and water and thermal management.
Indicators of Prognosis in Node-Negative Breast Cancer (1990)

Measures of the proliferative activity of tumor cells have prognostic value in patients with node-negative breast cancer. We studied 367 women in southern Sweden who had undergone surgical resection for such cancer. Tumor specimens were analyzed with DNA flow cytometry in order to estimate both the DNA content (ploidy) and the fraction of cells in the synthetic phase of the cell cycle (S phase). The median duration of follow-up was four years; 28 percent of the patients received adjuvant therapy, usually with tamoxifen (n = 83). A multivariate analysis based on complete data on 250 patients included the following covariates: age (greater than or equal to 75, 50 to 74, and less than or equal to 49 years), tumor size (less than or equal to 20 vs. greater than 20 mm), concentration of estrogen and progesterone receptors (less than 10 vs. greater than or equal to 10 fmol per milligram of protein), ploidy (diploid vs. nondiploid), and S-phase category (fraction of cells in S phase: less than 7.0 percent, 7.0 to 11.9 percent, and greater than or equal to 12 percent). The S-phase fraction yielded the most prognostic information, followed by progesterone-receptor status and tumor size. A prognostic model based on these three variables identified 37 percent of the patients as constituting a high-risk group with a fourfold increased risk of distant recurrence. In the remaining 63 percent of the patients, the five-year overall survival rate (92 +/- 4 [+/- SE] percent) did not differ from the expected age-adjusted rate for Swedish women. We conclude that a prognostic index that includes indicators of the proliferative activity of tumor cells may be able to identify women with node-negative breast cancer in whom the risk of recurrence is sufficiently low that adjuvant chemotherapy can be avoided.
A prototype of pneumatically-driven forceps manipulator with force sensing capability using a simple flexible joint (2011)

This paper presents the first prototype of pneumatically-driven forceps manipulator using a simple flexible joint with intrinsic force sensing. A high performance spring component with wire actuation is employed for two-degree of freedom (DOF) bending joint, and two-DOF tendon drive system is implemented by four pneumatic cylinders. Using a continuum model for the kinematics, a PD controller with static and dynamic compensation is designed for the position control, which shows a good performance at the sufficient working frequency for surgical operations. The forceps manipulator can estimate external forces using a disturbance observer. A link approximation model is introduced to design the observer as the first intuitive approach. The force estimation can be achieved with an accuracy of 0.2 N in the basic straight posture.
Spiral Surface Growth without Desorption (1998)

Spiral surface growth is well understood in the limit where the step motion is controlled by the local supersaturation of adatoms near the spiral ridge. In epitaxial thin-film growth, however, spirals can form in a step-flow regime where desorption of adatoms is negligible and the ridge dynamics is governed by the nonlocal diffusion field of adatoms on the whole surface. We investigate this limit numerically using a phase-field formulation of the Burton-Cabrera-Frank model, as well as analytically. Quantitative predictions, which differ strikingly from those of the local limit, are made for the selected step spacing as a function of the deposition flux, as well as for the dependence of the relaxation time to steady-state growth on the screw dislocation density.
A review of electromechanical actuators for More/All Electric aircraft systems (2017)

Conventional hydraulic actuators in aircraft systems are high maintenance and more vulnerable to high temperatures and pressures. This usually leads to high operating costs and low efficiency. With the rapid development of More/All Electric technology, power-by-wire actuators are being broadly employed to improve the maintainability, reliability, and manoeuvrability of future aircraft. This paper reviews the published application and development of the airborne linear electromechanical actuator. First, the general configuration, merits, and limitations of the gear-drive electromechanical actuator and the direct-drive electromechanical actuator are analysed. Second, the development state of the electromechanical actuator testing systems is elaborated in three aspects, namely the performance testing based on room temperature, testing in a thermal vacuum environment, and iron bird. Common problems and tendencies of the testing systems are summarized. Key technologies and research challenges are revealed in terms of fault-tolerant motor, high-thrust mechanical transmission, multidisciplinary modelling, thermal management, and thermal analysis. Finally, the trend for future electromechanical actuators in More/All Electric Aircraft applications is summarized, and future research on the airborne linear electromechanical actuators is discussed.
Recent advances in high resolution acoustic microscopy (1984)

Abstract A new form of microscopy, based on imaging with elastic waves, has evolved in recent years. The virtue of the acoustic microscope is that its contrast depends on the variation in elastic properties which is a fundamentally different process from the contrast mechanisms operative in an optical microscope. There are situations where the resolution capability of the scanning acoustic microscope is superior to that of the best optical microscope. These facts, together with the unique capability of the acoustic microscope to image the interior of optically opaque objects, have created a powerful new laboratory technique. The design of the acoustic microscope is reviewed and its principles of operation are discussed. Micrographs obtained with various techniques from a range of objects are illustrated. Techniques for subsurface imaging are discussed and illustrated by reference to a variety of results. An outline is given of possible future advances.
High-frequency, long-wavelength resonant-cavity-enhanced InGaAs MSM photodetectors (1996)

Resonant-cavity-enhanced InP/InGaAs metal-semiconductor-metal photodetectors for high-frequency and high-efficiency operation at 1.31 /spl mu/m wavelength under rear illumination are demonstrated. An external quantum efficiency of 77% and a 3-dB bandwidth of 10 GHz are achieved with an InGaAs absorber thickness of 300 nm.