gebhart/patrepeval huggingface dataset:
Integrated pharmacokinetic and metabolic modeling of selegiline and metabolites after transdermal administration (1997)

Selegiline (SEL) is a selective, irreversible inhibitor of MAO-B, used in the treatment of Parkinson's disease, either alone or as an adjunct to L-DOPA. Selegiline hydrochloride (HCl) undergoes significant first-pass metabolism following oral administration. Transdermal delivery avoids the first-pass effect and provides greater and more prolonged levels of unchanged SEL and reduced levels of metabolites (N-desmethylselegiline (DES), L-amphetamine (AMP), and L-methamphetamine (MET) compared to the oral regimen. An integrated pharmacokinetic-metabolic model which predicts plasma concentrations of SEL and metabolites following a single 24 h application of a selegiline transdermal system (STS) is proposed. The model is based on the metabolic conversion of SEL to DES and MET and subsequently to AMP. The input function is described by a zero-order constant for the delivery of SEL from the STS system based on in vitro studies of penetration of SEL across human skin. The elimination-non-metabolic constants for each analyte account for the urinary elimination. Plasma concentration data from a pilot pharmacokinetic study in which six healthy male volunteers were administered single 24 h applications of a 1.8 mg cm2, 10 cm2 STS were used to examine this model. The coefficient of determination was 0.98 and model selection criterion was 3.4 for mean data fits, supporting the goodness of fit of the model. The pharmacokinetic parameters obtained by non-compartmental analysis were comparable to those predicted by a compartmental model. The model also predicted urinary recoveries for AMP and MET and negligible recovery for SEL and DES consistent with recent studies with the STS in which urine was collected. The metabolic conversion constant from SEL to DES was significantly lower than the conversion constant from SEL to MET, indicating that metabolism of SEL is primarily driven towards MET following transdermal administration. The metabolic conversion from MET to AMP was less than the conversion from DES to AMP. This simultaneous prediction of the SEL and metabolites is essential as the metabolic ratios have been linked to the neuroprotective effects of SEL. These findings support the proposed regional delivery advantage attributed to the transdermal route compared to the conventional therapy with the oral tablet. Future model applications may also help identify significant covariates (i.e. age, gender, and disease state) in upcoming clinical trials.
Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia (2011)

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes encoding for ribosomal proteins. Among these genes, ribosomal protein S19 (RPS19) is mutated most frequently. Generation of animal models for diseases like DBA is challenging because the phenotype is highly dependent on the level of RPS19 down-regulation. We report the generation of mouse models for RPS19-deficient DBA using transgenic RNA interference that allows an inducible and graded down-regulation of Rps19. Rps19-deficient mice develop a macrocytic anemia together with leukocytopenia and variable platelet count that with time leads to the exhaustion of hematopoietic stem cells and bone marrow failure. Both RPS19 gene transfer and the loss of p53 rescue the DBA phenotype implying the potential of the models for testing novel therapies. This study demonstrates the feasibility of transgenic RNA interference to generate mouse models for human diseases caused by haploinsufficient expression of a gene.
Derivation of Optical Constants of Metals from Thin-Film Measurements at Oblique Incidence (1972)

The reflectance R and transmittance T of thin absorbing films deposited on a transparent substrate are calculated for normal and oblique incidence, s and p polarization, and different film thicknesses. The results are presented as contours of constant R and T on the ñ plane, where ñ is the complex refractive index. The conditions for sensitive dependence of measured quantities on ñ are examined. A computer-based method of finding ñ from chosen combinations of measured R or T values is described. Oblique incidence measurements on thin films can give accurate results in some regions where other methods may be less sensitive. Accurate film-thickness values can be obtained from the optical measurements.
Online grocery shopping in Australia (2003)

The Internet has been increasingly used to facilitate online business transactions between business entities and consumers for various products and services. One of the applications that has received much attention in the last few years is Online Grocery Shopping (OGS). However, the study of Online Grocery Shopping has been limited in number. To enrich the existing studies, this paper examines the potential of OGS in Australia through a survey study. In general, the findings indicate that the conditions of the Australian market support the use of Online Grocery Shopping in Australia.
Therapists' Gender Assumptions and How These Assumptions Influence Therapy (2001)

Summary The purpose of this study is to investigate therapists' construction of gender through an examination of clinicians' attributions of expressiveness and instrumentality. Ninety-nine therapists participated in this study by watching a 25 minute videotaped vignette of a clinician interviewing a Caucasian female-male couple. Half of the participants viewed a female actor performing an expressive role with a male actor performing an instrumental role, while the other half watched a tape where the roles were reversed. After viewing the video tape, the participants completed the Bem Sex Role Inventory for the husband and wife and two one-item measures of power and gender. The results indicated that the sex of the actor organized therapists' construction of expressiveness and instrumentality. For example, when the woman was performing the expressive role she was rated higher on expressiveness than the man when the man was performing the same role. These findings suggest that the dominant discourse on gender may have infiltrated therapists' empirical assessments of their clients' behavior. The relevance of this study to training is also discussed.
An integrated high-extinction-ratio low-loss polarization rotator for silicon photonics across C+L bands (2017)

We report an integrated silicon polarization rotator, with dual-level aligned fabrication. The rotator has record high 25-dB extinction, low 2-dB loss, with near-perfect rotation of 90.03±8.85 degrees across 100-nm wavelengths for chip-scale polarization diversity.
Linear imaging with sensor arrays on convex polygonal boundaries (1991)

The resolution of a linear imaging system is determined by the size of the aperture on which it measures data. For a fixed number of sensor elements, large 2-D apertures are formed when the elements are placed on the boundary of some planar region. It is proved that it is possible, in principle, to use only the boundary of some convex region as the aperture, while synthesizing the effect of having placed sensors throughout the interior of that region. This allows sidelobe levels to be controlled. Such a possibility is clearly of interest to designers of large, distributed sensor arrays for use in both active, transmit/receive imaging and passive, receive-only imaging. The central idea that is exploited in the work is that of the coarray of an aperture. Signal processing techniques have been developed that effectively fill in the missing elements from the interior of the aperture for the cases of rectangular, hexagonal, and triangular boundary apertures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
EmailTime: visual analytics and statistics for temporal email (2011)

Although the discovery and analysis of communication patterns in large and complex email datasets are difficult tasks, they can be a valuable source of information. We present EmailTime, a visual analysis tool of email correspondence patterns over the course of time that interactively portrays personal and interpersonal networks using the correspondence in the email dataset. Our approach is to put time as a primary variable of interest, and plot emails along a time line. EmailTime helps email dataset explorers interpret archived messages by providing zooming, panning, filtering and highlighting etc. To support analysis, it also measures and visualizes histograms, graph centrality and frequency on the communication graph that can be induced from the email collection. This paper describes EmailTime's capabilities, along with a large case study with Enron email dataset to explore the behaviors of email users within different organizational positions from January 2000 to December 2001. We defined email behavior as the email activity level of people regarding a series of measured metrics e.g. sent and received emails, numbers of email addresses, etc. These metrics were calculated through EmailTime. Results showed specific patterns in the use email within different organizational positions. We suggest that integrating both statistics and visualizations in order to display information about the email datasets may simplify its evaluation.
User ID Routing Architecture (2010)

This article presents a new efficient routing architecture based on user identifier protocol (UIP). It decouples the dual roles (identifier and locator) of IP in the existing Internet. A user ID is used to identify the user, whereas one or more than one locator is used to identify the location. The UIP can efficiently support the mobility and multihoming. In addition, it can support the special case that one user has more than one mobile/fixed equipments such as mobile phone and notebook.
Speech Recognition With the Advanced Combination Encoder and Transient Emphasis Spectral Maxima Strategies in Nucleus 24 Recipients (2005)

One of the difficulties faced by cochlear implant (CI) recipients is perception of low-intensity speech cues. A. E. Vandali (2001) has developed the transient emphasis spectral maxima (TESM) strategy to amplify short-duration, low-level sounds. The aim of the present study was to determine whether speech scores would be significantly higher with TESM than with the advanced combination encoder (ACE) strategy fitted using procedures that optimize perception of soft speech and other sounds. Eight adult recipients of the Nucleus 24 CI system participated in this study. No significant differences in scores were seen between ACE and TESM for consonant-vowel nucleus-consonant (CNC) words presented at 55 and 65 dB SPL, for sentences in noise presented at 65 dB SPL at 2 different signal-to-noise ratios, or for closed-set vowels and consonants presented at 60 dB SPL. However, perception of stop consonants within CNC words presented at the lower level (55 dB SPL) was significantly higher with TESM than ACE. In addition, percentage of information transmitted for words at 55 dB SPL was significantly higher with TESM than with ACE for manner and voicing features for consonants in the initial word position. Analysis of closed-set consonants presented at 60 dB SPL revealed percentage of information transmitted for manner was significantly higher with TESM than with ACE. These improvements with TESM were small compared with those reported by Vandali for recipients of the Nucleus 22 CI system. It appears that mapping techniques used to program speech processors and improved processing capabilities of the Nucleus 24 system contributed to soft sounds being understood almost as well with ACE as with TESM. However, half of the participants preferred TESM to ACE for use in everyday life, and all but 1 used TESM in specific listening situations. Clinically, TESM may be useful to ensure the audibility of low-intensity, short-duration acoustic cues that are important for understanding speech, for recipients who are difficult to map, or if insufficient time precludes the use of mapping techniques to increase audibility of soft sound.
In vitro Pharmacological Characterization of Mitemcinal (GM-611), the First Acid-Resistant Non-Peptide Motilin Receptor Agonist, in Smooth Muscle of Rabbit Small Intestine (2006)

The pharmacological properties of mitemcinal (GM-611), the first acid-resistant non-peptide motilin agonist, were investigated in the smooth muscle of the rabbit small intestine and compared with porcine motilin (pMTL), erythromycin A (EMA) and its derivatives (EM-523, EM-574 and ABT-229). Mitemcinal, pMTL, EMA, EM-523, EM-574 and ABT-229 produced concentration-dependent contractions with approximately the same maximum contractions in the isolated rabbit duodenum longitudinal strips. The contractile response to mitemcinal or pMTL was competitively inhibited by a selective motilin antagonist, GM-109. The pA(2) values for GM-109 as an antagonist of mitemcinal and pMTL showed approximately the same values. However, the concentration-dependent contractile responses to mitemcinal or pMTL were not affected by pretreatment with atropine, tetrodotoxin, hexamethonium, naloxone or tropisetron. The removal of calcium ions from the medium and pretreatment with verapamil greatly suppressed the contractions induced by mitemcinal and pMTL. The contractile response to mitemcinal was not affected by preincubation in acidic solutions, while those of EM-523, EM-574 and ABT-229 were strongly diminished in the same condition. Mitemcinal as well as other motilin agonists displaced (125)I-pMTL bound to a homogenate of the rabbit duodenum muscle tissue. The displacement curves of all these compounds were parallel. These results indicate that mitemcinal is a selective and full motilin receptor agonist in the smooth muscle of the rabbit small intestine and that this agent has an excellent acid-resistant property.
Solubility of Halogenated Hydrocarbon Refrigerants in Organic Solvents (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of Halogenated Hydrocarbon Refrigerants in Organic SolventsG. F. ZellhoeferCite this: Ind. Eng. Chem. 1937, 29, 5, 548–551Publication Date (Print):May 1, 1937Publication History Published online1 May 2002Published inissue 1 May 1937https://pubs.acs.org/doi/10.1021/ie50329a014https://doi.org/10.1021/ie50329a014research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Wideband Planar Microwave Lenses Using Sub-Wavelength Spatial Phase Shifters (2011)

We present a new technique for designing low-profile planar microwave lenses. The proposed lenses consist of numerous miniature spatial phase shifters distributed over a planar surface. The topology of each spatial phase shifter (SPS) is based on the design of a class of bandpass frequency selective surfaces composed entirely of sub-wavelength, non-resonant periodic structures. A procedure for designing the proposed lenses and their constituting spatial phase shifters is also presented in the paper. This design procedure is applied to two different planar lenses operating at X-band. Each lens is a low-profile structure with an overall thickness of 0.08λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> and uses sub-wavelength SPSs with dimensions of 0.2λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> × 0.2λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> , where λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> is the free-space wavelength at 10 GHz. These prototypes are fabricated and experimentally characterized using a free-space measurement system and the results are reported in the paper. The fabricated prototypes demonstrate relatively wide bandwidths of approximately 20%. Furthermore, the lenses demonstrate stable responses when illuminated under oblique angles of incidence. This feature is of practical importance if these lenses are to be used in beam-scanning antenna applications.
Laser gain and threshold properties in compressive-strained and lattice-matched GaInNAs/GaAs quantum wells (1999)

The optical gain spectra for compressive-strained and lattice-matched GaInNAs/GaAs quantum wells are computed using a microscopic laser theory. From these spectra, the peak gain and carrier radiative decay rate as functions of carrier density are determined. These dependences allow the study of lasing threshold current density for different GaInNAs/GaAs laser structures.
Clozier René, L'économie de l'Allemagne de l'Ouest. Paris, PUF, Coll. Que sais-je, n° 283, 1977 (1978)

Holz Jean-Marc. Clozier René, L'économie de l'Allemagne de l'Ouest. Paris, PUF, Coll. Que sais-je, n° 283, 1977. In: L'Espace géographique, tome 7, n°3, 1978. La géographie allemande contemporaine. p. 168.
A bond-wire inductor-MOS varactor VCO tunable from 1.8 to 2.4 GHz (2002)

This paper presents a technique that optimizes LC-tank CMOS voltage-controlled oscillators (VCOs) by minimizing the product of phase noise and power consumption. Moreover, it shows that the minimum depends on the tank's quality factor Q, the device noise coefficient /spl gamma/, and the ratio between the maximum oscillation amplitude and supply voltage /spl alpha/. Prototypes, realized in a 0.35-/spl mu/m process, show the following performances: -122.5 dBc/Hz at 600 kHz from a 1.9-GHz carrier, with 2-V supply voltage and 1-mA current consumption. The VCO can be tuned between 1.8-2.4 GHz, when the varactor control voltage is varied between 0-3.5 V. In the proposed realization, the tank is made of a metal-oxide-silicon varactor (operated between accumulation and deep depletion) and a bond-wire inductor, realized connecting two pads to a package frame lead to be compatible with the production environment.
Software Lock Mass by Two-Dimensional Minimization of Peptide Mass Errors (2011)

Mass accuracy is a key parameter in proteomic experiments, improving specificity, and success rates of peptide identification. Advances in instrumentation now make it possible to routinely obtain high resolution data in proteomic experiments. To compensate for drifts in instrument calibration, a compound of known mass is often employed. This 'lock mass' provides an internal mass standard in every spectrum. Here we take advantage of the complexity of typical peptide mixtures in proteomics to eliminate the requirement for a physical lock mass. We find that mass scale drift is primarily a function of the m/z and the elution time dimensions. Using a subset of high confidence peptide identifications from a first pass database search, which effectively substitute for the lock mass, we set up a global mathematical minimization problem. We perform a simultaneous fit in two dimensions using a function whose parameterization is automatically adjusted to the complexity of the analyzed peptide mixture. Mass deviation of the high confidence peptides from their calculated values is then minimized globally as a function of both m/z value and elution time. The resulting recalibration function performs equal or better than adding a lock mass from laboratory air to LTQ-Orbitrap spectra. This 'software lock mass' drastically improves mass accuracy compared with mass measurement without lock mass (up to 10-fold), with none of the experimental cost of a physical lock mass, and it integrated into the freely available MaxQuant analysis pipeline ( www.maxquant.org ).
Ten Essential Elements of an Effective Dispute Resolution Program (2008)

For an organization with a significant number of outstanding lawsuits and pre-litigation claims, it is important to have a comprehensive and disciplined program of managing disputes to produce optimal outcomes with consistency, effectiveness and cost efficiency. Based on my experience at large, complex industrial companies with well over 2,000 litigation matters outstanding at any time, the effective management of the dispute portfolio requires that each matter be managed effectively and that more matters be resolved each year than the number of new matters that arise. The focus of this article is corporate law departments, but the concepts are applicable to any organization. To manage disputes when matters are being handled by a number of in-house lawyers and retained outside counsel requires adherence to a coherent system that has the following critical elements.
Inhibition by vanadium of sodium and potassium dependent adenosinetriphosphatase derived from animal and human tissues. (1979)

Inhibition of adenosinetriphosphatase (ATPase) by vanadium pentoxide (dissolved in water or in sodium hydroxide solution) was studied in microsomal fractions and tissue homogenates of kidney, brain, and heart of several species, including humans (kidney only). In some preparations vanadium was found to be the most potent inhibitor of Na+ + K+ATPase activity so far reported. Concentrations of vanadium causing 50 percent inhibition of Na+ + K+ATPase activity ranged from 6 x 10(-8) to 5 x 10(-7) M in microsomal fractions and from 2 x 10(-7) to 1 x 10(-6) M in tissue homogenates. Renal and cardiac enzymes were more sensitive to vanadium than the brain enzyme, a phenomenon independent of enzyme specific activity. The enzyme in tissue homogenates was more resistant to vanadium than the microsomal enzyme derived from the same tissues, suggesting a presence in tissues of protective agents. Mg2+ ATPase, which contaminated the enzyme preparations to a variable degree, was 1,000-10,000 times more resistant to vanadium than was Na+ + K+ATPase. More detailed studies on the mechanism of inhibition were performed with dog and human kidney enzymes. The reversible nature of the inhibition was suggested by the fact that fractional inactivation of Na+ + K+ATPase by vanadium was independent of enzyme protein concentrations. The inhibitory effect was reduced by Na+ and increased by K+ or Mg2+. ATP alone, but not MgATP, antagonized the inhibition. This could mean that vanadium inhibits the Na+ + K+ATPase at the site activated by Na+, and that ATP protects the enzyme either by binding vanadium or by competing for a mutual receptor on the enzyme. The inhibition was reduced by bovine serum albumin, probably binding vanadium. The inhibition was also diminished by reducing agents, ascorbic acid and citric acid.