gebhart/patrepeval huggingface dataset:
Analytical and Thermal Modeling of High-Speed Machining With Chamfered Tools (2007)

Abstract High-speed machining offers several advantages such as increased flexibility and productivity for discrete-part manufacturing. However, excessive heat generation and resulting high temperatures on the tool and workpiece surfaces in high-speed machining leads to a shorter tool life and poor part quality, especially if the tool edge geometry and cutting conditions were not selected properly. In this study, analytical and thermal modeling of high-speed machining with chamfered tools in the presence of dead metal zone has been presented to investigate the effects of cutting conditions, heat generation, and resultant temperature distributions at the tool and in the workpiece. An analytical slip-line field model is utilized to investigate the process mechanics and friction at the tool-chip and tool-workpiece interfaces in the presence of the dead metal zone in machining with a negative rake chamfered polycrystalline cubic boron nitride tool. In order to identify friction conditions, a set of orthogonal cutting tests is performed on AISI 4340 steel and chip geometries and cutting forces are measured. Thermal modeling of machining with chamfered tools based on moving band heat source theory, which utilizes the identified friction conditions and stress distributions on the tool-chip and tool-workpiece interfaces, is also formulated and temperature distributions at the tool, cutting zone, and in the workpiece are obtained. These temperature distributions are compared with the results obtained from finite element simulations. The comparison of temperature fields indicates that the proposed model provides reasonable solutions to understand the mechanics of machining with chamfered tools. Models presented here can be further utilized to optimize the tool geometry and cutting conditions for increasing benefits that high-speed machining offers.
Environmental versus genetic risk factors for irritable bowel syndrome: clinical and therapeutic implications. (2005)

The pathogenesis of irritable bowel syndrome (IBS) has traditionally been based on the biopsychosocial model that emphasizes that the symptom manifestations of IBS and consulting behavior are influenced at least in part by psychological processes. However, there has been increasing interest in trying to identify and unravel potential molecular mechanisms in IBS, and this endeavor has been driven by some evidence that there is a true genetic contribution to IBS. IBS does aggregate in families, and the concordance of IBS is twice as great in monozygotic compared with dizygotic twins in most, but not all, studies. A number of genetic polymorphisms have been associated with IBS but most remain to be independently confirmed, and unknown gene-environment interactions probably remain essential for the disorder to manifest. As we become better able to specify the phenotypes within IBS, it seems likely that increasingly relevant gene associations that have implications for testing and treatment will rapidly be identified. IBS probably represents a collection of several organic diseases, some of which may have a genetic component; the biopsychosocial model, although important, may represent a gross oversimplification of the underlying molecular pathogenesis.
Application technology progress report: Evaluation of PM-10 commercial inlets and development of an inlet for new Rocky Flats Plant surveillance air sampler, January 1986-December 1986 (1987)

Work during 1986 was concerned with developing a new PM-10 inlet for use at Rocky Flats Plant (RFP), Golden, Colorado. The commercial units that we evaluated did not allow for recovery of the >10-..mu..m dust fraction as may be required by EPA and DOE for nuclear installations. One of them, the Wedding PM-10 Inlet, did not meet the PM-10 cut-point requirement, because of the build-up of vegetative fibers in the cyclone type separator. Therefore, we developed a new PM-10 inlet (patent applied for) to meet our needs, and especially one that is adaptable to our existing 60 surveillance air samplers at minimum cost. The inlet utilizes a modified slotted impactor design. This device is directly adaptable to existing EPA high-volume samplers. 9 refs., 5 figs., 1 tab.
Safety and Clinical Performance of Acoustic Reflex Tests (1999)

Sensitivity and specificity were higher for PTT asymmetry than for ART. Ipsilateral ART at 1000 Hz had poor sensitivity and specificity for detection of acoustic neuroma, and involves some potential risk to residual hearing for presentation levels higher than 115 dB SPL. Approximately half of the acoustic neuroma group had ipsilateral ARTs that would require administration of ARD tests at levels exceeding 115 dB SPL. Therefore, we conclude that PTT asymmetry is a more effective test for detection of acoustic neuroma, and involves no risk to residual hearing. Future studies of contralateral reflex threshold and ARD in combination with PTT asymmetry are recommended.
Total internal reflection enabled wide-field coherent anti-Stokes Raman scattering microscopy (2020)

Wide-field coherent anti-Stokes Raman scattering (CARS) microscopy offers an attractive means for the rapid and simultaneous acquisition of vibrationally resolved images across a large field of view. A major challenge in the implementation lies in how to achieve sufficiently strong excitation fields necessary to drive the third-order optical responses over the large focal region. Here, we report a new wide-field CARS microscope enabled by a total internal reflection excitation scheme using a femtosecond Ti:Sapphire oscillator to generate pump and broadband near-infrared Stokes pulses. The spectrally broad Stokes pulse, in combination with its inherent chirp, offers not only access to a wide range of Raman modes spanning <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mo>∼</mml:mo> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>1000</mml:mn> </mml:mrow> </mml:math> to <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mo>∼</mml:mo> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>3500</mml:mn> </mml:mrow> <mml:mspace width="thickmathspace"/> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msup> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="normal">c</mml:mi> <mml:mi mathvariant="normal">m</mml:mi> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> but also a straightforward means to select vibrational transitions within this range by simply varying the time delay between the pulses. The unique capabilities of this wide-field CARS microscope were validated by acquiring high-quality CARS images from the model and complex biological samples on conventional microscope coverslips.
Rescue of protein splicing activity from a Magnetospirillum magnetotacticum intein-like element (2004)

The self-catalytic protein splicing mechanism is mediated by the intein plus the first amino acid following the intein C-terminus (termed the +1 residue). Although polymorphisms of conserved residues elsewhere in inteins have been widely reported, no splicing-competent intein has been observed without a Ser, Thr or Cys in this functionally essential +1 position. This residue is the nucleophile in two steps of the protein splicing pathway: ligation of the extein fragments during transesterification and formation of a peptide bond between the exteins by an acyl rearrangement. An intein-like element in a hypothetical protein (gene Magn8951) from Magnetospirillum magnetotacticum has all intein signature sequences except the +1 residue, where it has a Tyr. Although the Tyr side-chain hydroxyl can potentially mediate the transesterification reaction, an acyl shift has never been observed with this residue. When the activities of this bacterial intein-like element were studied, protein splicing was not observed and N-terminal cleavage predominated. Mutation of Tyr+1 to Phe or Ala indicated that the Tyr side-chain hydroxyl was not necessary for N-terminal cleavage. Protein splicing activity could be rescued by "reversion" of Tyr+1 to Cys.
A novel virus-inducible enhancer of the interferon-β gene with tightly linked promoter and enhancer activities (2014)

Long-range enhancers of transcription are a key component of the genomic regulatory architecture. Recent studies have identified bi-directionally transcribed RNAs emanating from these enhancers known as eRNAs. However, it remains unclear how tightly coupled eRNA production is with enhancer activity. Through our systematic search for long-range elements that interact with the interferon-β gene, a model system for studying inducible transcription, we have identified a novel enhancer, which we have named L2 that regulates the expression of interferon-β. We have demonstrated its virus-inducible enhancer activity by analyzing epigenomic profiles, transcription factor association, nascent RNA production and activity in reporter assays. This enhancer exhibits intimately linked virus-inducible enhancer and bidirectional promoter activity that is largely dependent on a conserved Interferon Stimulated Response Element and robustly generates virus inducible eRNAs. Notably, its enhancer and promoter activities are fully retained in reporter assays even upon a complete elimination of its associated eRNA sequences. Finally, we show that L2 regulates IFNB1 expression by siRNA knockdown of eRNAs, and the deletion of L2 in a BAC transfection assay. Thus, L2 is a novel enhancer that regulates IFNB1 and whose eRNAs exert significant activity in vivo that is distinct from those activities recapitulated in the luciferase reporter assays.
Mesopore-modified mordenites as catalysts for catalytic pyrolysis of biomass and cracking of vacuum gasoil processes (2013)

Mesopore-modified mordenite zeolitic materials with different Si/Al ratios have been prepared and tested in the biomass pyrolysis and catalytic cracking of vacuum gasoil. Alkaline treatment was carried out to generate mesoporosity. Severity of alkaline treatment was found to be of paramount importance to tune the generated mesoporosity, while it significantly affected the crystallinity of treated mordenites. It was moreover observed that the alkaline treatment selectively extracted Si decreasing the Si/Al ratio of treated samples. Catalytic activity of parent and alkaline treated mordenites was studied in the pyrolysis of biomass. All zeolitic based materials produced less amounts of bio-oil but of better quality (lowering the oxygen content from ∼40% to as much as 21%) as compared to the non-catalytic pyrolysis experiments. On the other hand, it was found that the combination of mesopore formation and high surface area after alkaline treatment of the mordenite with a high Si/Al ratio resulted in the enhancement of its catalytic activity, despite the reduction of its acidity. The increment of the decarboxylation and dehydration reactions, combined with a reduction of carbon deposition on the catalyst, resulted in a remarkable decrease in the oxygen content in the organic fraction and therefore, resulted in a superior quality liquid product. Alkaline treated mordenites were additionally acid treated targeting dealumination and removal of the extra framework debris, thus generating mesopore-modified mordenite samples with stronger acid sites and higher total acidity, as candidate catalysts for catalytic cracking of vacuum gasoil. Desilicated and especially desilicated and dealuminated mordenites exhibited the highest activity and selectivity towards LCO with the best olefinicity in gases and higher bottoms conversion. Therefore, an optimized desilicated–dealuminated mordenite additive could be an interesting candidate as a component of the FCC catalyst for a high LCO yield.
Aqueous Foams: A Field of Investigation at the Frontier Between Chemistry and Physics (2008)

This paper reviews the properties of aqueous foams. The current state of knowledge is summarized briefly and the interdisciplinary aspects of this field of investigation are emphasized. Many phenomena are controlled by physical laws, but they are highly dependent upon the chemicals used as foam stabilizers: surfactants, polymers, particles. Most of the existing work is related to surfactants and polymer foams, and little is known yet for particle foams although research in this field is becoming popular. This article presents the general concepts used to describe the monolayers and the films and also some of the recent advances being made in this area.
Epileptogenicity of Focal Malformations Due to Abnormal Cortical Development: Direct Electrocorticographic–Histopathologic Correlations (2003)

This study shows that areas containing BCs are less epileptogenic than are closely located dysplastic regions. These results suggest a possible protective effect of BCs or a severe disruption in the neuronal networks in BCs containing dysplastic lesions. Further studies are needed to elucidate the nature and the potential role(s) of balloon cells in MCD-induced epileptogenicity.
Strategies Employed in the Synthesis of Prostacyclins and Thromboxanes (1984)

Les reactions cles intervenant dans la synthese des prostaglandines I et des thromboxanes sont repertoriees
The C-H.cntdot..cntdot..cntdot.O hydrogen bond in crystals: what is it? (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe C-H.cntdot..cntdot..cntdot.O hydrogen bond in crystals: what is it?Gautam R. DesirajuCite this: Acc. Chem. Res. 1991, 24, 10, 290–296Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/ar00010a002https://doi.org/10.1021/ar00010a002research-articleACS PublicationsRequest reuse permissionsArticle Views3095Altmetric-Citations1083LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quantitative material characterization from multi‐energy photon counting CT (2013)

Initial application of the proposed methodology suggests that it can decompose multi-energy CT images into quantitative maps of water, adipose, iodine, and calcium concentrations.
Bright and Ultrafast Photoelectron Emission from Aligned Single-Wall Carbon Nanotubes through Multiphoton Exciton Resonance (2018)

Ultrashort bunches of electrons, emitted from solid surfaces through excitation by ultrashort laser pulses, are an essential ingredient in advanced X-ray sources, and ultrafast electron diffraction and spectroscopy. Multiphoton photoemission using a noble metal as the photocathode material is typically used but more brightness is desired. Artificially structured metal photocathodes have been shown to enhance optical absorption via surface plasmon resonance but such an approach severely reduces the damage threshold in addition to requiring state-of-the-art facilities for photocathode fabrication. Here, we report ultrafast photoelectron emission from sidewalls of aligned single-wall carbon nanotubes. We utilized strong exciton resonances inherent in this prototypical one-dimensional material, and its excellent thermal conductivity and mechanical rigidity leading to a high damage threshold. We obtained unambiguous evidence for resonance-enhanced multiphoton photoemission processes with definite power-law behaviors. In addition, we observed strong polarization dependence and ultrashort photoelectron response time, both of which can be quantitatively explained by our model. These results firmly establish aligned single-wall carbon nanotube films as novel and promising ultrafast photocathode material.
Approximate Performance Analysis of Wireless Ultraviolet Links (2007)

The wireless ultraviolet (UV) communication technology has received great attention for either short-range high data-rate services or medium-to-large range low-rate sensing applications. However, performance of a UV link is limited by multiple constraints from the current UV laser source and detector technology, and atmospheric link conditions. This paper analyzes performance of both line of sight (LOS) and non-line of sight (NLOS) UV links in terms of signal to noise ratio and bit error rate of the detector. Roles of different parameters, such as data rate, communication range, transmitter power, beam and focal angle, receiving angle and field of view, are studied. Receiving powers for two typical links demonstrate square and linear decaying laws with respect to the communication range respectively. Compared with an LOS link, an NLOS link significantly degrades detection performance from one up to three orders of magnitude for the range from hundreds of meters down to meters.
Enabling Privacy-Preserving, Compute- and Data-Intensive Computing using Heterogeneous Trusted Execution Environment (2019)

There is an urgent demand for privacy-preserving techniques capable of supporting compute and data intensive (CDI) computing in the era of big data. However, none of existing TEEs can truly support CDI computing tasks, as CDI requires high throughput accelerators like GPU and TPU but TEEs do not offer security protection of such accelerators. This paper present HETEE (Heterogeneous TEE), the first design of TEE capable of strongly protecting heterogeneous computing with unsecure accelerators. HETEE is uniquely constructed to work with today's servers, and does not require any changes for existing commercial CPUs or accelerators. The key idea of our design runs security controller as a stand-alone computing system to dynamically adjust the boundary of between secure and insecure worlds through the PCIe switches, rendering the control of an accelerator to the host OS when it is not needed for secure computing, and shifting it back when it is. The controller is the only trust unit in the system and it runs the custom OS and accelerator runtimes, together with the encryption, authentication and remote attestation components. The host server and other computing systems communicate with controller through an in memory task queue that accommodates the computing tasks offloaded to HETEE, in the form of encrypted and signed code and data. Also, HETEE offers a generic and efficient programming model to the host CPU. We have implemented the HETEE design on a hardware prototype system, and evaluated it with large-scale Neural Networks inference and training tasks. Our evaluations show that HETEE can easily support such secure computing tasks and only incurs a 12.34% throughput overhead for inference and 9.87% overhead for training on average.
Is Fecal Calprotectin the Next Standard in Inflammatory Bowel Disease Activity Tests? (1999)

1Crohn's Disease Analyst San Francisco, California Reprint requests and correspondence: Mihailo Alic, 3720 Balboa Street, San Francisco, CA 94121 Received June 8, 1999; accepted June 16, 1999.
Preparation of organoaluminum compounds by hydrozirconation-transmetalation (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of organoaluminum compounds by hydrozirconation-transmetalationDenise B. Carr and Jeffrey SchwartzCite this: J. Am. Chem. Soc. 1979, 101, 13, 3521–3531Publication Date (Print):June 1, 1979Publication History Published online1 May 2002Published inissue 1 June 1979https://pubs.acs.org/doi/10.1021/ja00507a017https://doi.org/10.1021/ja00507a017research-articleACS PublicationsRequest reuse permissionsArticle Views1575Altmetric-Citations123LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Polyspecific natural antibodies and autoantibodies secreted by human lymphocytes immortalized with Epstein-Barr virus (1988)

Recent studies have shown that autoreactive B cells and autoantibodies are present in pathological as well as in normal situations. In the present study, we immortalized human B cell lines from normal individuals and from patients with malignant or benign dysglobulinemia with Epstein-Barr virus and examined, after cloning, the autoantibody reactivities of the immunoglobulins secreted by these cells. Forty-two supernatants were analyzed by enzyme-immunoassay on a panel of 13 self and non-self antigens: trinitrobenzenesulfonic acid (TNP), DNA, L-glutamine, L-alanine, L-tyrosine (GAT), actin, myosin, tubulin, albumin, renin, spectrin, transferrin, thyroglobulin, myoglobin, peroxidase, and by immunofluorescence in tissue sections. Fourteen (33%) of the immunoglobulin-secreting cell lines were found to have an autoantibody function; seven secreted IgM, six IgA, and one IgG. The light chains were of the kappa type in 11 cases. The vast majority of these clones reacted with more than five antigens of the panel and all of them reacted with TNP. No correlation was found between a given isotype and an antibody specificity. More than half of these antibodies also reacted with cellular antigens present in tissue sections. None of the four cell lines secreting monoclonal antiviral antibodies reacted with any of the antigens of the panel. The results indicate that immunoglobulins secreted by human monoclonal lymphoid cell lines can have polyspecific autoantibody functions, similar to those found in normal human polyclonal antibodies, in human monoclonal paraproteins and in natural monoclonal antibodies synthesized by murine or rat clones obtained from physiologically normal animals.
Quasi-Optical Power Combining of Solid-State Millimeter-Wave Sources (1986)

Very efficient power combining of solid-state millimeter-wave sources may be obtained through the application of quasi-optical resonators and monotfthic source arrays. Through the theory of reiterative wavebeams (beam modes) with application of the Lorentz reciprocity theorem, it is shown that planar source arrays containing 25 individual elements or more result in very efficient power transfer of energy from the source arrays to the fundamental wave-beam mode. It is further shown that for identical sources within a properly designed quasi-optical power combiner, the output power tends to increase much faster that number of source elements.