gebhart/patrepeval huggingface dataset:
An Iterative Meta-Lifecycle for Software Development, Evolution and Maintenance (2008)

Modern organizations are significantly affected by the breakthroughs in the field of information technology. In particular, software systems play a critical role in supporting organizations operational and decisional processes. Given that the costs of development and maintenance of software constitute the largest part of the computerization cost, the survival of organizations depends heavily on the effectiveness of the software development process. However, software engineering is in crisis. This crisis, known as the ldquosoftware crisis", is characterized by economic and social ramifications and exacerbated by the complexity and uncertainty inherent in both software engineering and organizational processes supported by software. Many researchers believe that prototyping can reduce uncertainty and provide knowledge related to the future dynamic states of software systems before their construction. Nevertheless, few methods incorporating prototyping as a tool for reducing uncertainty have been proposed to date. In this paper, we propose a framework for an iterative development process which integrates software prototyping. This framework permits correcting some weaknesses of existing methods by emphasizing the multidimensional nature of the software and the multiplicity of actors involved in software development, maintenance, and use.
Mobilization of peripheral blood progenitor cells after DHAP regimen with or without rituximab: A large multicenter comparative study in patients with malignant lymphoma (2007)

DHAP regimen is commonly used in patients with lymphoma. It is routinely used in combination with the monoclonal anti-CD20 antibody rituximab (R-DHAP), particularly for peripheral blood stem cell (PBSC) mobilization. The aim of this study was to assess the impact of rituximab on PBSC mobilization in patients with lymphoma receiving DHAP chemotherapy. We retrospectively reviewed the data of patients treated by DHAP or R-DHAP regimens as PBSC mobilization protocol between July 1998 and June 2005. Sixty-nine patients were included in the study: 21 in the DHAP group and 48 in the R-DHAP group. Both groups were not statistically different in term of clinical and biological presentation of the disease. The first cytapheresis was performed at day 10 in the R-DHAP group versus day 11 in the DHAP group. In contrast, the number of circulating CD34(+) cells was higher, but not significant, in the R-DHAP group than the DHAP group, namely 9.7x10(6) CD34(+) cells/kg and 6.1x10(6) CD34(+) cells/kg, respectively. Finally, the complete remission status at time of harvest was the only one factor associated with poor mobilization on multivariate analysis. In conclusion, our results show that rituximab does not impair PBSC collection.
NSC23925, Identified in a High-Throughput Cell-Based Screen, Reverses Multidrug Resistance (2009)

The ability of NSC23925 to restore sensitivity to the cytotoxic effects of chemotherapy or to prevent resistance could significantly benefit cancer patients.
Tip Length Models for Major Commercial California Conifers (1995)

Several models for predicting the length from the merchantable top to the tip of a tree are evaluated for major California conifers. A model reported by (Wensel and Krumland (1983)) was found to be the most useful because of its ability to predict for both total height or merchantable height. Coefficients are reported for eight commercially important conifers of California.
TOPICAL p38MAPK INHIBITION REDUCES DERMAL INFLAMMATION AND EPITHELIAL APOPTOSIS IN BURN WOUNDS (2006)

Thermal injury induces dermal inflammatory and proapoptotic signaling. These phenomena extend burn wound size and trigger a systemic inflammatory response, factors known to adversely affect outcomes. p38MAPK is known to trigger inflammatory responses and induce epithelial proapoptotic genes. We hypothesize that topical p38MAPK inhibition will attenuate excessive inflammatory and apoptotic signaling and reduce dermal tissue loss. Rats were given a 30% total body surface area partial thickness burn or sham injury. Some of the animals were treated with a p38MAPK inhibitor or vehicle, which was applied directly to the wound. Dermal inflammation was investigated with enzyme-linked immunosorbent assay, reverse transcriptase polymerase chain reaction, myeloperoxidase assay, and Evans blue extravasation. Apoptotic changes were detected using terminal deoxynucleotidyl transferase dUTP nick-end labeling assay and Caspase-3 in situ staining. Burn injury activated dermal p38MAPK and induced a significant rise in dermal IL-6, TNF-alpha, and IL-1beta expression. Neutrophil sequestration, microvascular damage, and hair follicle apoptosis were significantly elevated after injury. Topical p38MAPK inhibition significantly attenuated downstream dermal p38MAPK targets, proinflammatory cytokine expression, neutrophil sequestration, and microvascular injury. A significant reduction in hair follicle apoptosis was seen. This study demonstrates the attenuation of burn-induced cellular stress by topical application of p38MAPK inhibitors. Blunting early excessive inflammatory signaling may be an efficient strategy to improve patient outcomes after burn injury.
On feedback stabilization of time-varying discrete linear systems (1978)

Results are given for stabilizing time-varying discrete linear systems by means of a feedback control stemming from a receding-horizon concept and a minimum quadratic cost with a fixed terminal constraint. The results parallel those recently obtained for continuous-time systems [8] and extend a well-known method of Kleinman for stabilizing discrete fixed linear systems [7].
Semantic Descriptions for Logical Content Generation (2015)

Human designers understand a range of potential purposes behind objects and configurations when creating content, which are only partially addressed in typical procedural content generation techniques. This paper describes our research into the provision and use of semantic information to guide logical solver-based content generation, in order to feasibly generate meaningful and valid content. Initial results show we can use answer set programming to generate basic roguelike dungeon layouts from a provided semantic knowledge base, and we intend to extend this to generate a range of other content types. By using semantic models as input for a content-agnostic generation system, we hope to provide more domain-general content generation.
Bilin deletions and subunit stability in cyanobacterial light‐harvesting proteins (1998)

Light-harvesting in cyanobacteria and red algae is a function of the biliproteins, which have covalently bound bilin chromophores. The biliproteins are assembled with linker proteins into the phycobilisome, a large complex that resides on the surface of the photosynthetic membranes. Early steps in the phycobilisome assembly pathway include the folding of biliprotein alpha- and beta-subunits, covalent modification of subunits by bilin attachment and formation of the primary assembly unit, the alphabeta heterodimer. The potential role of bilins in subunit structure and assembly is examined in this study by site mutagenesis of biliprotein genes. Phycocyanin subunits from Synechocystis sp. 6701 that were unable to bind chromophores at specific sites were generated by changing the codons for bilin-binding cysteines to alanine residues. The altered genes were then expressed in a phycocyanin-minus mutant of the transformable Synechocystis sp. strain 6803. Single and multiple chromophore deletions cause specific and reproducible variations in phycobilisome-associated phycocyanin that do not correlate with transcript levels. Sedimentation equilibrium studies with purified proteins showed that bilin absence reduces the strength of alphabeta interaction in the heterodimer. These results suggest that phycocyanin instability in bilin-deletion mutants is a consequence of diversion of unassembled alpha- and beta-subunits to a degradation pathway. Attachment of the central bilin, which is common to all biliprotein subunits, may facilitate alphabeta interaction by completing the final stage of subunit folding and stabilizing the contact domains of binding partners in the heterodimer.
Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition (2021)

VRC01 did not prevent overall HIV-1 acquisition more effectively than placebo, but analyses of VRC01-sensitive HIV-1 isolates provided proof-of-concept that bnAb prophylaxis can be effective. (Supported by the National Institute of Allergy and Infectious Diseases; HVTN 704/HPTN 085 and HVTN 703/HPTN 081 ClinicalTrials.gov numbers, NCT02716675 and NCT02568215.).
Manifestations and mechanisms of stem cell aging (2011)

Adult stem cells exist in most mammalian organs and tissues and are indispensable for normal tissue homeostasis and repair. In most tissues, there is an age-related decline in stem cell functionality but not a depletion of stem cells. Such functional changes reflect deleterious effects of age on the genome, epigenome, and proteome, some of which arise cell autonomously and others of which are imposed by an age-related change in the local milieu or systemic environment. Notably, some of the changes, particularly epigenomic and proteomic, are potentially reversible, and both environmental and genetic interventions can result in the rejuvenation of aged stem cells. Such findings have profound implications for the stem cell-based therapy of age-related diseases.
Growth, transport, and magnetic properties of Pr<b>0.67</b>Ca<b>0.33</b>MnO<b>3</b> thin films (1996)

We have grown Pr0.67Ca0.33MnO3 thin films on LaAlO3 using pulsed laser deposition. Below 50 K, a field induced insulator-metal transition results in changes in resistivity of at least 6 orders of magnitude. The field induced conducting state is metastable at low temperature. The temperature dependence of the resistivity exhibits considerable hysteresis in a field of 40 kOe but becomes reversible in a field of 80 kOe.
The response of suction caissons in normally consolidated clays to cyclic TLP loading conditions (1995)

This paper describes a series of seven cyclic loading test performed in a centrifuge to evaluate the behavior of steel suction caissons under uplift loadings with soil conditions typical of deepwater Gulf of Mexico (GOM). Suction caissons are large cylindrical foundation units installed with active suction after partial penetration by deadweight. They derive most of their uplift resistance from passive suction. The tests were performed to simulate a prototype caisson with a 50-ft diameter and about a 100-ft penetration below the mudline. A primary objective of the testing programs involved the application of cyclic loads representative of the actual loads predicted for a deepwater Tension Leg Platform (TLP) during a design storm. Tests were conducted for a range of inclinations from vertical including: (1) purely vertical, (2) at a 6 inclination, and (3) at an inclination angle that varied during the test. The results obtained from these tests established the combination of the cyclic load ratio (cyclic load divided by the static uplift resistance) and the number of applied cycles that cause failure of the foundation. For cyclic load ratios of 0.48, 0.34 and 0.27 with no fixed static load the number of cycles required to cause failure were approximatelymore » 100, 500, and 1,000 respectively. The tests where the inclination angle varied experienced the most reduction in capacity. Finally a 55-ft diameter by 110-ft long caisson in normally consolidated soils was shown to satisfy design criteria for a 100-year design storm in the Gulf of Mexico.« less
Improvement of Oral Drug Treatment by Temporary Inhibition of Drug Transporters and/or Cytochrome P450 in the Gastrointestinal Tract and Liver: An Overview (2002)

The oral bioavailability of many cytotoxic drugs is low and/or highly variable. This can be caused by high affinity for drug transporters and activity of metabolic enzymes in the gastrointestinal tract and liver. In this review, we will describe the main involved drug transporters and metabolic enzymes and discuss novel methods to improve oral treatment of affected substrate drugs. Results of preclinical and clinical phase I and II studies will be discussed in which affected substrate drugs, such as paclitaxel, docetaxel, and topotecan, are given orally in combination with an inhibitor of drug transport or drug metabolism. Future randomized studies will, hopefully, confirm that this strategy for oral treatment is at least as equally effective and safe as standard intravenous administration of these drugs.
Sinewave fit algorithm based on total least-squares method with application to ADC effective bits measurement (1997)

Sinewave fit is a fundamental task in many test and measurement systems. The characterizations of analog-digital converters and digital oscilloscopes are two examples. In this paper, we present a high-performance (i.e., high-precision and high-speed) algorithm to estimate the four parameters of a sinewave from a sample data record. By the use of trigonometric identity, we propose a frequency estimator that turns the nonlinear estimation problem into a linear one. Thus, the difficulty of the traditional nonlinear least-squares sinewave fit method is attenuated. The total least-squares method is used to estimate four parameters of a sinewave in order to minimize the estimation errors in the sense of l/sub 2/ norm. Simulation results exhibit that the proposed method gives superior performance over traditional ones and achieves excellent estimation of the true resolution of the simulated ideal ADC. This new algorithm is noniterative and gives swift and consistent results.
The regio- and stereoselectivity of Bu4N[Fe(CO)3NO]-catalyzed allylic alkylation (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe regio- and stereoselectivity of Bu4N[Fe(CO)3NO]-catalyzed allylic alkylationYuanyao Xu and Bo ZhouCite this: J. Org. Chem. 1987, 52, 6, 974–977Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/jo00382a002https://doi.org/10.1021/jo00382a002research-articleACS PublicationsRequest reuse permissionsArticle Views1185Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermal degradation of ammonium polymethacrylate and polymethacrylamide (1978)

Abstract The degradation of ammonium polymethacrylate and polymethacrylamide has been studied by a combination of thermal analysis methods (TVA and TG) and examination of volatile and involatile products by infrared analysis. It is shown that total reaction comprises an initial cyclization and further fragmentation of the modified chain at higher temperatures to yield gaseous volatiles. The partially degraded NH 4 PMA contains anhydride ring and cyclic imide structures in the chain. Quantitative comparison of yields of isocyanic acid and carbon dioxide has shown that imidization is the major reaction and anhydride formation is of less importance. The mechanisms of the various reactions are discussed.
GEOLOGICAL MODEL EVALUATION THROUGH WELL TEST SIMULATION: A CASE STUDY FROM THE <i>WYTCH FARM</i> OILFIELD, SOUTHERN ENGLAND (2007)

This paper presents an approach to the evaluation of reservoir models using transient pressure data. Braided fluvial sandstones exposed in cliffs in SW England were studied as the surface equivalent of the Triassic Sherwood Sandstone, a reservoir unit at the nearby Wytch Farm oilfield. Three reservoir models were built; each used a different modelling approach ranging in complexity from stochastic pixel‐based modelling using commercially available software, to a spreadsheet random number generator. In order to test these models, numerical well test simulations were conducted using sector models extracted from the geological models constructed. The simulation results were then evaluated against the actual well test data in order to find the model which best represented the field geology. Two wells at Wytch Farm field were studied. The results suggested that for one of the sampled wells, the model built using the spreadsheet random number generator gave the best match to the well test data. In the well, the permeability from the test interpretation matched the geometric average permeability. This average is the “correct” upscaled permeability for a random system, and this was consistent with the random nature of the geological model. For the second well investigated, a more complex “channel object” model appeared to fit the dynamic data better. All the models were built with stationary properties. However, the well test data suggested that some parts of the field have different statistical properties and hence show non‐stationarity. These differences would have to be built into the model representing the local geology. This study presents a workflow that is not yet considered standard in the oil industry, and the use of dynamic data to evaluate geological models requires further development. The study highlights the fact that the comparison or matching of results from reservoir models and well‐test analyses is not always straightforward in that different models may match different wells. The study emphasises the need for integrated analyses of geological and engineering data. The methods and procedures presented are intended to form a feedback loop which can be used to evaluate the representivity of a geological model.
Naval applications of electrical remote-positional controllers (1947)

A survey is made in this paper of some of the applications in the Royal Navy of all-electric servo mechanisms for armament control purposes.The need for the greatest possible measure of automatic operation in fire-control prediction, and in the pointing of the guns in accordance with this prediction, in order to combat high-speed aircraft and to make the fullest possible use of the continuously up-to-date location of the target by radar, led to the introduction of the servo and remote power-control systems described.By far the greater part of the systems referred to in the paper are therefore the results of development and application to specific projects over the past ten years. Brief reference is, however, made in the first part of the paper to some earlier forms of servo mechanisms of the contact-operated type used in the Navy, since this is of interest as a background to the later and more modern types of continuously operating servos, which have largely superseded them.This is followed by a description of some applications of highperformance servos of small or medium powers. These are mostly of the type using a split-field d.c. motor in which the armature of the motor is supplied direct from the d.c. supply through a series resistance (to limit the current at standstill) and the motor fields from a thermionic amplifier under the control of the servo transmission.Finally a description is given of remote power-control applications of large power in which the initial amplification is by thermionic amplifier, but in which further power amplification is obtained from rotating machines (Metadyne and Ward-Leonard) feeding the armatures of separately excited d.c. motors which drive the load.A general reference only has been made to the M-type and magslip electrical data-transmission systems used for the servos and remote power-control schemes described, since information concerning them is given in the paper on “Data-Transmission Systems” by Mr. J. Bell.
Oxidative Stress in Traumatic Brain Injury (2014)

Traumatic brain injury (TBI) is a major healthcare concern, constituting a major cause of death and disability throughout the world. Among the factors leading to TBI outcome are biochemical cascades which occur in response to primary and secondary injury. These mechanisms generate oxidative stress, an imbalance between oxidant and antioxidant agents that can result in neural dysfunction and death. After TBI, an assembly of oxidative stress markers (carbonylated proteins, lipid peroxides, reactive oxygen and reactive nitrogen species) are produced in the brain, while antioxidant defense enzymes decrease (GSH, ratio GSH/GSSG, GPx, GR, GST, G-6PD, SOD, CAT). This imbalance is directly related to the pathogenesis of TBI. Therefore, the development of antioxidant strategies is of primary interest in ongoing efforts to optimize brain injury treatment. The success of any drug intervention strategy relies, in part, on knowledge of the optimal dosage and therapeutic window for its administration. But while the enzymes involved in oxidative stress have been identified, the temporal course of this imbalance following TBI has yet to be determined. This would explain why most antioxidant strategies developed to treat patients with TBI have failed.
Short-term Digital Surface Microscopic Monitoring of Atypical or Changing Melanocytic Lesions (2001)

On the assumption that all melanoma will change during the monitored period, surface microscopy digital monitoring is a useful adjunct for the management of melanocytic lesions.
A Primer on Quantitized Data Analysis and Permutation Testing (2012)

Quantitization refers to transforming qualitative data into numerical format. Approaches to quantitization include dichotomizing qualitative themes and counting qualitative codes. Statistical analysis of themes and code counts has the potential to produce valuable information for mixed methods researchers. Examples of quantitized statistical analysis are presented along with ways in which the results can provide useful insights. With regard to analyzing code counts, due to limitations associated with traditional parametric and nonparametric tests of significance, permutation testing is offered as a rigorous alternative. A detailed example of permutation testing using readily available resampling software is provided.
Article Watch: September 2014 (2014)

This column highlights recently published articles that are of interest to the readership of this publication. We encourage ABRF members to forward information on articles they feel are important and useful to Clive Slaughter, Georgia Regents University-University of Georgia Medical Partnership, 1425 Prince Ave., Athens, GA 30606, USA. Phone: 706-713-2216; Fax: 706-713-2221; E-mail: ude.agu@thgualsc; or to any member of the Editorial Board. Article summaries reflect the reviewer's opinions and not necessarily those of the association.