gebhart/patrepeval huggingface dataset:
Development and Validation of a Diagnostic DNA Microarray To Detect Quinolone-Resistant <i>Escherichia coli</i> among Clinical Isolates (2004)

The incidence of resistance against fluoroquinolones among pathogenic bacteria has been increasing in accordance with the worldwide use of this drug. Escherichia coli is one of the most relevant species for quinolone resistance. In this study, a diagnostic microarray for single-base-mutation detection was developed, which can readily identify the most prevalent E. coli genotypes leading to quinolone resistance. Based on genomic sequence analysis using public databases and our own DNA sequencing results, two amino acid positions (83 and 87) on the A subunit of the DNA gyrase, encoded by the gyrA gene, have been identified as mutation hot spots and were selected for DNA microarray detection. Oligonucleotide probes directed against these two positions were designed so that they could cover the most important resistance-causing and silent mutations. The performance of the array was validated with 30 clinical isolates of E. coli from four different hospitals in Germany. The microarray results were confirmed by standard DNA sequencing and were in full agreement with phenotypic antimicrobial susceptibility testing.
Melatonin in perioperative medicine: Current perspective (2013)

Melatonin, a new addition to the armamentarium of anesthesiologist, has some unique properties that are highly desirable in routine peri-operative care. Available clinical data show that preoperative melatonin is as effective as benzodiazepines in reducing preoperative anxiety with minimal action on psychomotor performance and sleep wake cycle. It may be considered as a safe and effective alternative of benzodiazepines as preoperative anxiolytic. It may have opioid sparing effect, may reduce intraocular pressure, and have role in prevention of postoperative delirium. The short-term administration of melatonin is free from significant adverse effects also.
Preparation of Well‐Defined PVOH/C60 Nanohybrids by Cobalt‐Mediated Radical Polymerization of Vinyl Acetate (2006)

Abstract Summary: Poly(vinyl acetate) chains end‐capped by a Co(acac) 2 complex [PVAc‐Co(acac) 2 ] were prepared by bulk cobalt‐mediated radical polymerization (CMRP) of vinyl acetate and used for grafting fullerene (C60) with four PVAc arms at low temperature (30 °C). A photoactive water‐soluble poly(vinyl alcohol)/C60 nanohybrid was then prepared by hydrolysis of the PVAc arms of the nanohybrid. Because of photoactivity and very low cytotoxicity, this type of water‐soluble nanohybrid is very promising for the photodynamic cancer therapy. Strategy for the preparation of PVAc/C60 nanohybrid and hydrolysis of PVAc/C60 nanohybrid into PVOH/C60 nanohybrid. magnified image Strategy for the preparation of PVAc/C60 nanohybrid and hydrolysis of PVAc/C60 nanohybrid into PVOH/C60 nanohybrid.
Electronic Structures and Chemical Bonds of Cobaltite and Ni-Doped (2005)

The relation among electronic structure, chemical bond and thermoelectric property of Ca3 Co2 O6 and Ni-doped was studied by density function theory and discrete variation method(DFT-DVM). The results indicate that the highest valence band (HVB) and the lowest conduction band(LCB) are mainly attributed to Co3 d, Ni3 d and O2 p atomic orbitals. The property of a semiconductor is shown from the gap between HVB and LCB. The gap of Ni-doped one is less than that of Ca3 Co2 O6. The non-metal bond or ceramic characteristic of Ni-doped one is weaker than that of Ca3 Co2 O6, but the metal characteristics of Ni-doped one are stronger than those of Ca3 Co2O6. The thermoelectric property should be improved by adding Ni element into the system of Ca3 Co2 O6.
Mechanisms responsible for vasodilation upon magnesium infusion in vivo: clinical evidence. (2002)

A number of studies have shown that intravenous administration of magnesium (Mg) is an effective treatment for acute coronary syndromes. While mechanisms such as antiarrhythmic, antithrombotic, and myocardial cytoprotective effects may be involved, a vasodilatory effect is among the likely beneficial effects of Mg infusion. The vasodilatory effect of Mg is incompletely understood. On one hand, Mg can act as a physiologic calcium-antagonist, but in addition interest recently has been focused on whether endothelium-derived nitric oxide is involved in Mg-induced vasodilation. Another issue in Mg-induced vasodilation is whether the specific Mg salt administered influence the degree of vasodilation. Although Mg sulphate has undergone more clinical studies than Mg chloride, experimental studies suggest that Mg chloride influences vasculature more than Mg sulphate. No clinical research has investigated whether the vasodilatory effect of Mg differs according to the associated anion administered. The present review includes evidence concerning mechanisms of the vasodilatory effect of Mg including endothelium-derived nitric oxide, as well as the possible differences between different Mg salts.
HTTP adaptive streaming with Media Fragment URIs (2011)

HTTP adaptive streaming was introduced with the general idea that user agents interpret a manifest file (describing different representations and segments of the media); where-after they retrieve the media content using sequential HTTP progressive download operations. MPEG started with the standardization of an HTTP streaming protocol, defining the structure and semantics of a manifest file and additional restrictions and extensions for container formats. At the same time, W3C is working on a specification for addressing media fragments on the Web using Uniform Resource Identifiers. The latter not only defines the URI syntax for media fragment identifiers but also the protocol for retrieving media fragments over HTTP. In this paper, we elaborate on the role of Media Fragment URIs within HTTP adaptive streaming scenarios. First, we elaborate on how different media representations can be addressed by means of Media Fragment URIs, by using track fragments. Additionally, we illustrate how HTTP adaptive streaming is realized relying on the Media Fragments URI retrieval protocol. To validate the presented ideas, we implemented Apple's HTTP Live streaming technique using Media Fragment URIs.
Demodex Mites Contain Immunoreactive Lipase (1989)

To the Editor.— Demodex mites are parasites normally present in human skin. In up to 10% of skin biopsy samples, these organisms can be seen as an incidental finding colonizing the pilosebaceous complex.1 It is well known that the greatest concentration of Demodex is found in areas where sebaceous glands are numerous and sebum production is pronounced.2 Aylesworth and Vance1 demonstrated that the face is by far the most heavily infested area, especially the temple and the nasal region. To a lesser degree, Demodex have been found around nipples, neck, chest, back, and genital regions.3 An isolated report has shown the presence of Demodex in ectopic sebaceous glands of the oral mucosa.4 This observation suggests that Demodex has an affinity for the sebaceous glands, and that hair follicles need not be present for the mites' survival.
Nacionalni identitet naspram europskog identiteta (2000)

razlikuje etiri razine integracije: regionalnu, nacionalnu, europsku
HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates (2016)

A single-cycle herpes simplex virus (HSV) deleted in glycoprotein D (ΔgD-2) elicited high titer HSV-specific antibodies (Abs) that (i) were rapidly transported into the vaginal mucosa; (ii) elicited antibody-dependent cell-mediated cytotoxicity but little neutralization; (iii) provided complete protection against lethal intravaginal challenge; and (iv) prevented establishment of latency in mice. However, clinical isolates may differ antigenically and impact vaccine efficacy. To determine the breadth and further define mechanisms of protection of this vaccine candidate, we tested ΔgD-2 against a panel of clinical isolates in a murine skin challenge model. The isolates were genetically diverse, as evidenced by genomic sequencing and in vivo virulence. Prime and boost immunization (s.c.) with live but not heat- or UV-inactivated ΔgD-2 completely protected mice from challenge with the most virulent HSV-1 and HSV-2 isolates. Furthermore, mice were completely protected against 100 times the lethal dose that typically kills 90% of animals (LD90) of a South African isolate (SD90), and no latent virus was detected in dorsal root ganglia. Immunization was associated with rapid recruitment of HSV-specific FcγRIII- and FcγRIV-activating IgG2 Abs into the skin, resolution of local cytokine and cellular inflammatory responses, and viral clearance by day 5 after challenge. Rapid clearance and the absence of latent virus suggest that ΔgD-2 elicits sterilizing immunity.
Effect of blameworthiness and outcome severity on attributions of responsibility and damage awards in comparative negligence cases. (1997)

We studied the effects of accident victims' legal blameworthiness and the severity of their injuries on determinations of responsibility and damage awards. In general, participants tended to ascribe more fault to victims than warranted by the facts presented, displaying an antiplaintiff bias. When attributing fault and awarding damages, they were especially sensitive to the blameworthiness of the victim when the consequences of the accident were severe rather than mild. These findings appeared not to be mediated by emotional reactions to the victims. Participants tended to conflate issues of liability with what ought to have been the legally distinct question of damages. They appeared to decide comparative negligence awards not by determining percentage fault and gross damages as discrete items and then computing their product, as the law prescribes, but rather by using more holistic judgmental processes.
The spectral recording process (1987)

La dilatation-compression des signaux est inaudible si les composantes frequentielles de grande amplitude sont modulees selectivement sans affecter les amplitudes des composantes. On evite ainsi les distorsions et on reduit le bruit dans le canal d'enregistrement ou de transmission
Primary cilia of human endothelial cells disassemble under laminar shear stress (2004)

We identified primary cilia and centrosomes in cultured human umbilical vein endothelial cells (HUVEC) by antibodies to acetyl-alpha-tubulin and capillary morphogenesis gene-1 product (CMG-1), a human homologue of the intraflagellar transport (IFT) protein IFT-71 in Chlamydomonas. CMG-1 was present in particles along primary cilia of HUVEC at interphase and around the oldest basal body/centriole at interphase and mitosis. To study the response of primary cilia and centrosomes to mechanical stimuli, we exposed cultured HUVEC to laminar shear stress (LSS). Under LSS, all primary cilia disassembled, and centrosomes were deprived of CMG-1. We conclude that the exposure to LSS ends the IFT in cultured endothelial cells.
A DEFECT DETECTION SCHEME FOR WEB SURFACE INSPECTION (2000)

The goal of this work was to develop an improved defect detection scheme for high-speed real-time web surface inspection. This goal was realized by splitting the task into two independent parts: feature extraction and segmentation. Both parts were implemented using efficient algorithms which were implemented in hardware that is suitable and fast enough to be included in a working web inspection system. The proposed scheme is based on some derived texture features and a new self-organizing map variant, the statistical self-organizing map. These techniques offer several improvements over the gray-level thresholding techniques that have been traditionally used in commercial web inspection systems.
Large aperture point-focusing diffractor for x rays (1988)

A doubly bent germanium single crystal with toroidally curved crystal planes was used to obtain three-dimensional focusing of monochromatic x rays from a microfocus source. The Johansson geometry in radial planes was obtained by cutting a cylindrically curved lamella, polishing, etching, and bending over a spherical mold of ∼50 mm radius at 740 °C. The bent crystal was aligned to obtain the Cu Kα (333) reflection in the spot which had a principal focus of ∼100 μm. Allowing for anode pitting and extraneous reflections, the observed x-ray intensity was ∼10 times lower than expected theoretically. The discrepancy was attributed to imperfect bending and crystal defects.
The 5′-Untranslated Region of the <i>ntp303</i> Gene Strongly Enhances Translation during Pollen Tube Growth, But Not during Pollen Maturation (2002)

Transcripts of the ntp303 gene accumulate abundantly throughout pollen development, whereas the protein only accumulates to detectable levels after pollen germination. In an attempt to explain the divergence in the accumulation profiles of the mRNA and the protein, we investigated the role of the untranslated regions (UTRs) in enhancing ntp303 translation during the transition from developing to germinating pollen. Luciferase reporter gene fusion constructs containing the ntp303 5'-UTR gave rise to luciferase activity that was up to 60-fold higher during pollen tube growth than that of constructs containing different 5'-UTRs. No apparent differences in the luciferase activity of these constructs were observed during pollen development. The ntp303 5'-UTR-mediated increase in luciferase activity was not significantly influenced by coding region or 3'-UTR sequences. Furthermore, enhanced luciferase activity directed by the ntp303 5'-UTR occurred predominantly at the post-transcriptional level. A series of 5'-UTR deletion constructs was created to identify putative regulatory sequences required for the high level of translation during pollen tube growth. Two predicted stem loop structures (H-I and H-II) caused a complete inhibition of the enhanced translation after their total or partial deletion. A (GAA)(8) repeat within the H-I stem loop structure was demonstrated to be important for the modulation of translation efficiency. The H-II stem loop structure was found to be essential for the determination of mRNA stability.
Über Verbindungen mit Urotropin‐Struktur, XXIV<sup>1)</sup> Derivate des 1‐Amino‐adamantans (1962)

Abstract Die Herstellung von Adamantyl‐(1)‐isocyanat und N.N ′‐Di‐[adamantyl(I)]‐carbodiimid wird beschrieben. Beide Verbindungen zeigen ein ungewöhnlich geringes Reaktionsvermögen.
The link prediction problem for social networks (2003)

Given a snapshot of a social network, can we infer which new interactions among its members are likely to occur in the near future? We formalize this question as the link prediction problem, and develop approaches to link prediction based on measures the of nodes in a network. Experiments on large co-authorship networks suggest that information about future interactions can be extracted from network topology alone, and that fairly subtle measures for detecting node proximity can outperform more direct measures.
Issue #1 - September 15, 1966 (1967)

Sept. 15, 1966. 4pgs.
Editor - John Adams. Editorial: It is obvious that the Election Act is critically lacking. Film review - Virginia Woolf. Jim McDonald, Student Council President married to Carol Gray, former Council Secretary Autonomy - Glendon is to become a totally independent College with non-voting representative status on S.R.C. No money is to be granted to S.R.C. without Council approval. All S.R.C. legislation must be passed by the Council before it becomes binding on students.
Editor: John Adams
Business manager: Michael Woohough
Entertainment editor: Larry Goldstein
Photo editor: Ron Lieberman
Layout: Paul Mandell
autonomy
voters
pearson
carol is resigned, jim is groomed
c.u.s.
editorial
letters
so where are the broads? by Larry dAvies
turkey today
virginia woolf by Larry Goldstein
al's alley by Alan Offstein
york profs
new secretary
the village
selling out? by Larry Goldstein
Inhibition of DNA synthesis and enhancement of the uptake and action of methotrexate by low-power-density microwave radiation in L1210 leukemia cells. (1980)

We have studied the effects of low-power-density microwave (MW) radiation (continuous and pulsed wave with average power density of 10 milliwatts/sq cm and range of 5 to 50 milliwatts/sq cm; frequency, 1.0 GHz) on the uptake and action of methotrexate (MTX), the inhibition of DNA synthesis in L1210 murine leukemia cells in vitro, and the MTX treatment of mice bearing this leukemia. Using short-term tissue culture techniques, MTX concentrations of 0.2 microM, and MW exposure times of 20 min, we have found that continuous-wave low-power-density MW irradiation enhances the uptake of [3H]MTX as compared to nonirradiated controls. The enhancement is observed in only a small range of power densities (5 to 25 milliwatts/sq cm) and is in an inverted-U-shaped relationship. MW irradiation alone has an inhibitory effect on the [3H]deoxyuridine incorporation into DNA. Compared to cell suspensions treated with MTX alone, groups treated with MW irradiation followed by MTX exhibit an augmentation of inhibition of DNA synthesis as measured by [3H]deoxyuridine incorporation. Combined treatment of L1210-bearing mice with MW irradiation and MTX in vivo prolonged the duration of survival over that of animals treated with MTX alone, indicating a greater killing of leukemia cells. These results suggest that the therapeutic index of MTX may be improved by the use of MW irradiation at low power densities.
Modeling analysis of AlN and AlGaN HVPE (2009)

Abstract Comprehensive model of AlN and AlGaN HVPE is developed. The model combines detailed description of the transport processes and quasi‐thermodynamic model of surface kinetics at the Al/Ga metal surfaces and AlN/AlGaN crystal surfaces. It is shown with the model that HCl dominantly converts into trichloride AlCl 3 in the Al source but into monochloride GaCl in the Ga source. Then, AlN grows from AlCl 3 under essentially non‐equilibrium conditions while GaN – from GaCl under near‐equilibrium conditions. The revealed differences between the AlN and GaN growth features explain many experimentally observed phenomena, including a sharp saturated behavior of the AlN growth rate in variation of the precursors flow rates and a strong effect of carrier H 2 on the AlGaN composition. Generally, the model predicts a high sensitivity of the AlGaN composition to variation of the species flow rates due to their effect on the Ga incorporation. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Epitaxial growth of ZnO nanowall networks on GaN/sapphire substrates (2007)

Heteroepitaxy of vertically well-aligned ZnO nanowall networks with a honeycomblike pattern on GaN∕c-Al2O3 substrates by the help of a Au catalyst was realized. The ZnO nanowall networks with wall thicknesses of 80–140nm and an average height of about 2μm were grown on a self-formed ZnO thin film during the growth on the GaN∕c-Al2O3 substrates. It was found that both single-crystalline ZnO nanowalls and catalytic Au have an epitaxial relation to the GaN thin film in synchrotron x-ray scattering experiments. Hydrogen-sensing properties of the ZnO nanowall networks have also been investigated.
Temperature‐dependent diffusion coefficient of soluble substances during ethanol extraction of clove (1996)

Abstract The temperature dependence of the diffusion coefficient of ethanol‐soluble substances from ground cloves (particle size 250 μm) during extraction was estimated by fitting batch extraction data at several temperatures (27.8, 40, 50, and 60°C) to a previously developed mass transfer model. The model was based on spherical geometry of particles. Nonlinear regression analysis was used to develop an equation that describes the diffusivity as a function of temperature. The temperature dependence of D A was of the Arrhenius type.
Photodissociation of oxygenated cytochrome o(s) (Vitreoscilla) and kinetic studies of reassociation. (1986)

Oxygenated cytochrome o(s) from Vitreoscilla was photodissociated by a laser flash but the quantum yield was low. The rebinding of oxygen to the ferrous cytochrome proceeded monophasically, and the second order rate constant was 7.8 X 10(7) M-1 s-1, the off rate constant 5.6 X 10(3) s-1, and the calculated dissociation constant for the oxygenated compound 7.2 X 10(-5) M at pH 7.3 and 25 degrees C. Rapid scanning spectroscopy revealed the formation of chytochrome o-O2 directly from ferrous chytochrome o and oxygen without any evidence for an intermediary formation of Compound D, another type of oxygenated chytochrome o. Photodissociation in solution containing CO/O2 mixtures resulted in rapid binding of oxygen followed by slow replacement by CO. This property as well as the photodissociability of chytochrome o-O2 suggests that the heme iron of the compound is in the ferrous state. In addition, the primary oxygen compound was fairly stable and did not decay further in the absence of CO, in marked contrast with that of mammalian cytochrome oxidase primary oxygen compound which rapidly decayed. This result suggests a possible role of this cytochrome as an oxygen carrier or storage.
Fault localization using execution traces (1992)

This paper describes an approach to the automatic localization of program faults using execution traces. The traces are used to construct a directed graph that models the propagation of values during execution. Knowledge of which output values are incorrect is then used to narrow the region that must be examined by the person debugging the program. Algorithms to construct and analyze the graph have been designed and implemented.
Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo (2007)

Isomerisation to all-trans-retinoic acid (ATRA) is widely accepted as the key mechanism underlying the favourable clinical properties of 13-cis-retinoic acid (13cisRA). As intracellular metabolism of ATRA by CYP26 may result in clinical resistance to 13cisRA, an increase in efficacy may be achieved through modulation of this metabolic pathway. We have evaluated the effect of the CYP26 inhibitor R116010 on retinoid metabolism in neuroblastoma cell lines and a xenograft model. In neuroblastoma cells, which showed a high level of CYP26 induction in response to ATRA, R116010 selectively inhibited ATRA metabolism. In addition, siRNA-mediated knockdown of CYP26 selectively increased ATRA levels and the expression of retinoid-responsive marker genes was potentiated by R116010. Treatment of mice bearing SH-SY5Y xenografts with 13cisRA (100 mg kg(-1)) revealed substantial levels (16%) of intratumoral ATRA after 6 h, despite plasma ATRA levels representing only 1% total retinoids under these conditions. Co-administration of R116010 with 13cisRA in this mouse model resulted in significant increases in plasma ATRA and 13cisRA concentrations. Furthermore, R116010 induced significant decreases in levels of 4-oxo metabolites in hepatic tissue after co-administration with either ATRA or 13cisRA. These data suggest considerable potential for CYP26 inhibitors in the future treatment of neuroblastoma with 13cisRA.
Transient-based identification of wireless sensor nodes (2009)

Identification of wireless sensor nodes based on the characteristics of their radio transmissions can provide an additional layer of security in all-wireless multi-hop sensor networks. Reliable identification can be means for the detection and/or prevention of wormhole, Sybil and replication attacks, and can complement cryptographic message authentication protocols. In this paper, we investigate the feasibility of transient-based identification of CC2420 wireless sensor nodes. We propose a new technique for transient-based identification and show that it enables reliable and accurate sensor node recognition with an Equal Error Rate as low as 0.0024 (0.24%). We investigate the performance of our technique in terms of parameters such as distance, antenna polarization and voltage and analyze how these parameters affect the recognition accuracy. Finally, we study the feasibility of certain types of impersonation attacks on the proposed technique.