gebhart/patrepeval huggingface dataset:
Targeted Imaging of Esophageal Neoplasia with a Fluorescently Labeled Peptide: First-in-Human Results (2013)

Esophageal adenocarcinoma is rising rapidly in incidence and usually develops from Barrett's esophagus, a precursor condition commonly found in patients with chronic acid reflux. Premalignant lesions are challenging to detect on conventional screening endoscopy because of their flat appearance. Molecular changes can be used to improve detection of early neoplasia. We have developed a peptide that binds specifically to high-grade dysplasia and adenocarcinoma. We first applied the peptide ex vivo to esophageal specimens from 17 patients to validate specific binding. Next, we performed confocal endomicroscopy in vivo in 25 human subjects after topical peptide administration and found 3.8-fold greater fluorescence intensity for esophageal neoplasia compared with Barrett's esophagus and squamous epithelium with 75% sensitivity and 97% specificity. No toxicity was attributed to the peptide in either animal or patient studies. Therefore, our first-in-human results show that this targeted imaging agent is safe and may be useful for guiding tissue biopsy and for early detection of esophageal neoplasia and potentially other cancers of epithelial origin, such as bladder, colon, lung, pancreas, and stomach.
A new construction of 64-QAM golay complementary sequences (2006)

In this correspondence, we present a new construction for 64-QAM Golay sequences of length n=2/sup m/ for integer m. The peak envelope power (PEP) of 64-QAM Golay sequences is shown to be bounded by 4.66n. The new construction of 64-QAM Golay sequences of length n=2/sup m/ is based on our earlier construction of new offsets of 16-QAM Golay sequences which are also presented here. The total number of offsets of 64-QAM Golay sequences is 496 for m=2,808 for m=3 and 976 for m=4, obtained by computer search. We also computed the PEP distribution for 64-QAM Golay sequences for m=2, m=3, and m=4.
Anomalous intensity effects in the IR spectrum of a densely packed monolayer of 4-acetoxybenzoic acid immobilized on oxidized aluminum. Conformational and vibrational analysis with AM1 (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnomalous intensity effects in the IR spectrum of a densely packed monolayer of 4-acetoxybenzoic acid immobilized on oxidized aluminum. Conformational and vibrational analysis with AM1A. H. M. Sondag, A. J. W. Tol, and F. J. TouwslagerCite this: Langmuir 1992, 8, 4, 1127–1135Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/la00040a019https://doi.org/10.1021/la00040a019research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Site-specific cleavage of the protein calmodulin using a trifluoperazine-based affinity reagent (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSite-specific cleavage of the protein calmodulin using a trifluoperazine-based affinity reagentAlanna Schepartz and Bernard CuenoudCite this: J. Am. Chem. Soc. 1990, 112, 8, 3247–3249Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ja00164a075https://doi.org/10.1021/ja00164a075research-articleACS PublicationsRequest reuse permissionsArticle Views414Altmetric-Citations104LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Localized psoriasis herpeticum: Case report and review of literature (2011)

Kaposi's varicelliform eruption (KVE) is a widespread cutaneous eruption caused by viruses, especially herpes simplex virus in patients with pre-existing dermatoses. "Psoriasis herpeticum" refers to the rare occurrence of KVE in patients with psoriasis. We report a case of KVE localized to the face in a patient with exfoliative dermatitis secondary to psoriasis. This case is being reported to make the treating clinician aware of the possibility of KVE in patients with psoriatic erythroderma.
FOOD, DRUGS, AND COSMETICS Common Sense Consumption Act: Provide for Limited Liability of Food Manufacturers, Packers, Distributors, and Others from Claims Relating to Weight Gain and Obesity; Provide for Exceptions to Such Liability; Provide for Pleading Requirements Relating to Claims; Provide for a Stay During the Pendency of Any Motion; Provide for Applicability of Claims; Provide for Related Matters; Repeal Conflicting Laws; and for Other Purposes (2004)

The Act prohibits consumers from filing claims against food manufacturers, packers, distributors, and others, based on the legal theory that the foods caused weight gain or obesity. However, there are exceptions to the limited liability for adulteration or misbranding violations and any other material federal or state law violations. The Act provides definitions of terms and requires that one plead with particularity any claims arising under the exemption for adulteration or misbranding.
SS7 MTP2-User Peer-to-Peer Adaptation Layer (2000)

This Internet Draft defines a protocol supporting the transport of SS7
MTP Layer 3 signaling messages over IP using the services of the
Stream Control Transmission Protocol (SCTP). This protocol would be
used between SS7 Signaling Points employing the MTP Level 3 protocol.
The SS7 Signaling Points may also employ standard SS7 links using the
SS7 Message Transfer Part (MTP) Layer 2 to provide transport of MTP
Layer 3 signaling messages.
CMOS Flat-Panel X-ray Detector With Dual-Gain Active Pixel Sensors and Column-Parallel Readout Circuits (2014)

This paper proposes a CMOS flat-panel X-ray detector (FPXD) with dual-gain active pixel sensors (APSs) and column-parallel readout circuits to reduce the random noise. The proposed dual-gain APS employs the conversion gain control in a pixel sensor array and supports both high and low sensitivity modes for FPXD. The in-pixel conversion gain control suppresses the amplification of the pixel noise, so it improves signal-to-noise characteristics. The column-parallel readout circuits include single-slope analog-to-digital converters (SS-ADCs) and charge-summing circuits for pixel binning and analog double delta sampling (DDS). SS-ADCs support 12-bit resolution and use the driving method of gray-code counters with different initial values to reduce the peak current and the power fluctuation. They also employ a high resolution continuous-type ramp generator to reduce the area. The proposed CMOS FPXD with a pixel size of 100 μm × 100 μm was fabricated using a 0.18-μm CMOS process. The conversion gains in high and low sensitivity modes are designed with 0.43 μV/e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> and 3.00 μV/e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> , respectively. The measured random noises in high and low sensitivity modes are 366 μV and 400 μV, respectively, at the resolution of 12 bits and the frame rate of 30 fps. The area of ramp generator and the peak current of the gray-code counter are reduced by 92% and 43%, respectively, compared with the conventional structures.
Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenza (2010)

The population-based incidence of admission to hospital with laboratory-confirmed pandemic (H1N1) influenza was low in the first five months of the pandemic in Canada. The risk of a severe outcome was associated with the presence of one or more underlying medical conditions, age of 20 years or more and a delay in hospital admission.
Endoglin Null Endothelial Cells Proliferate Faster and Are More Responsive to Transforming Growth Factor β1 with Higher Affinity Receptors and an Activated Alk1 Pathway (2005)

Endoglin is an accessory receptor for transforming growth factor beta (TGFbeta) in endothelial cells, essential for vascular development. Its pivotal role in angiogenesis is underscored in Endoglin null (Eng-/-) murine embryos, which die at mid-gestation (E10.5) from impaired yolk sac vessel formation. Moreover, mutations in endoglin and the endothelial-specific TGFbeta type I receptor, ALK1, are linked to hereditary hemorrhagic telangiectasia. To determine the role of endoglin in TGFbeta pathways, we derived murine endothelial cell lines from Eng+/+ and Eng-/- embryos (E9.0). Whereas Eng+/+ cells were only partially growth inhibited by TGFbeta, Eng-/- cells displayed a potent anti-proliferative response. TGFbeta-dependent Smad2 phosphorylation and Smad2/3 translocation were unchanged in the Eng-/- cells. In contrast, TGFbeta treatment led to a more rapid activation of the Smad1/5 pathway in Eng null cells that was apparent at lower TGFbeta concentrations. Enhanced activity of the Smad1 pathway in Eng-/- cells was reflected in higher expression of ALK1-dependent genes such as Id1, Smad6, and Smad7. Analysis of cell surface receptors revealed that the TGFbeta type I receptor, ALK5, which is required for ALK1 function, was increased in Eng-/- cells. TGFbeta receptor complexes were less numerous but displayed a higher binding affinity. These results suggest that endoglin modulates TGFbeta signaling in endothelial cells by regulating surface TGFbeta receptors and suppressing Smad1 activation. Thus an altered balance in TGFbeta receptors and downstream Smad pathways may underlie defects in vascular development and homeostasis.
Targeting a KH-domain protein with RNA decoys (2002)

RNA-binding proteins are involved in the regulation of many aspects of eukaryotic gene expression. Targeted interference with RNA-protein interactions could offer novel approaches to modulation of expression profiles, alteration of developmental pathways, and reversal of certain disease processes. Here we investigate a decoy strategy for the study of the alphaCP subgroup of KH-domain RNA-binding proteins. These poly(C)-binding proteins have been implicated in a wide spectrum of posttranscriptional controls. Three categories of RNA decoys to alphaCPs were studied: poly(C) homopolymers, native mRNA-binding sites, and a high-affinity structure selected from a combinatorial library. Native chemistry was found to be essential for alphaCP decoy action. Because alphaCP proteins are found in both the nucleus and cytoplasm, decoy cassettes were incorporated within both nuclear (U1 snRNA) and cytoplasmic (VA1 RNA) RNA frameworks. Several sequences demonstrated optimal decoy properties when assayed for protein-binding and decoy bioactivity in vitro. A subset of these transcripts was shown to mediate targeted inhibition of alphaCP-dependent translation when expressed in either the nucleus or cytoplasm of transfected cells. Significantly, these studies establish the feasibility of developing RNA decoys that can selectively target biologic functions of abundant and widely expressed RNA binding proteins.
Role of manganese peroxidases and lignin peroxidases of Phanerochaete chrysosporium in the decolorization of kraft bleach plant effluent (1991)

The role of lignin peroxidases (LIPs) and manganese peroxidases (MNPs) of Phanerochaete chrysosporium in decolorizing kraft bleach plant effluent (BPE) was investigated. Negligible BPE decolorization was exhibited by a per mutant, which lacks the ability to produce both the LIPs and the MNPs. Also, little decolorization was seen when the wild type was grown in high-nitrogen medium, in which the production of LIPs and MNPs is blocked. A lip mutant of P. chrysosporium, which produces MNPs but not LIPs, showed about 80% of the activity exhibited by the wild type, indicating that the MNPs play an important role in BPE decolorization. When P. chrysosporium was grown in a medium with 100 ppm of Mn(II), high levels of MNPs but no LIPs were produced, and this culture also exhibited high rates of BPE decolorization, lending further support to the idea that MNPs play a key role in BPE decolorization. When P. chrysosporium was grown in a medium with no Mn(II), high levels of LIPs but negligible levels of MNPs were produced and the rate and extent of BPE decolorization by such cultures were quite low, indicating that LIPs play a relatively minor role in BPE decolorization. Furthermore, high rates of BPE decolorization were seen on days 3 and 4 of incubation, when the cultures exhibit high levels of MNP activity but little or no LIP activity. These results indicate that MNPs play a relatively more important role than LIPs in BPE decolorization by P. chrysosporium.
Biosynthesis of Calcitonin by Human Lung Cancer Cells* (1985)

The ectopic secretion of calcitonin (CT) by a wide variety of nonthyroidal human tumors has been studied by CT RIA, but little information is available concerning the biosynthesis of CT in these tumors. In the present study, a human lung cancer cell line (BEN), secreting high mol wt forms of CT was investigated to characterize the CT gene products synthesized. When conditioned medium from BEN cells was chromatographed through a Bio-Gel P-30 column, larger species of immunoreactive CT were detected with mol wt of approximately 8,000 and 18,000. Little, if any, CT of 3,500 mol wt was detected. To examine CT gene products produced in BEN cells, poly A+ RNA was isolated from BEN cells and subjected to cell-free translation assays and DNA/RNA hybridization assays. In the wheat germ cell-free translation assay, a single BEN cell product which migrated on sodium dodecyl sulfate-polyacrylamide gels with an apparent mol wt of 17,000 could be specifically immunoprecipitated with CT antisera. A similar sized CT-related translation product is produced in wheat germ assays programmed by mRNA prepared from human medullary thyroid carcinomas. In DNA/RNA hybridization assays, a single BEN cell mRNA species of 1,000 base pairs, identical in size to human thyroidal CT mRNA, hybridized to a radiolabeled CT cDNA probe. Hybridization of the CT cDNA probe with BEN cell mRNA was confirmed by RNA dot blot hybridization and cytoplasmic RNA blotting procedures. These results indicate that larger mol wt forms of CT secreted by BEN cells are derived from a translation product and a mRNA which are of similar, if not identical, size as CT gene products produced in human thyroidal tissues. The inability of lung tumor cells to process the CT precursor to calcitonin of 3,500 mol wt may reflect a lack of specific prohormone processing enzymes in these tumor cells or may be due to structural polymorphism in the CT precursor expressed in the lung cells.
One systemic administration of transforming growth factor-beta 1 reverses age- or glucocorticoid-impaired wound healing. (1993)

The role of intravenously administered recombinant human transforming growth factor-beta 1 (rhTGF-beta 1) on the healing of incisional wounds in rats with impaired healing due to age or glucocorticoid administration was investigated. The administration of methylprednisolone to young adult rats decreased wound breaking strength to 50% of normal control. Breaking strength of incisional wounds from 19-mo-old rats was decreased approximately 27% compared with wounds from normal healing young adult rats. A single intravenous administration of rhTGF-beta 1 (100 or 500 micrograms/kg) increased wound breaking strength from old rats or young adult rats with glucocorticoid-induced impaired healing to levels similar to normal healing control animals when determined 7 d after injury. Even though the circulating half-life of systemically administered rhTGF-beta 1 is < 5 min, a sustained stimulatory effect on extracellular matrix secretion was evident in glucocorticoid-impaired rats when rhTGF-beta 1 was administered at the time of wounding, 4 h after wounding, or even 24 h before wounding. These observations indicate a previously unrecognized potential for the active form of TGF-beta 1 to profoundly influence the wound healing cascade after brief systemic exposure.
Possible Species of Ferromagnetic, Ferroelectric, and Ferroelastic Crystals (1970)

A ferromagnetic, ferroelectric, or ferroelastic crystal is called full or partial, according to whether all or not all but some of its orientation states are different in spontaneous magnetization vector, spontaneous polarization vector, or spontaneous strain tensor. In previous theories --- for nonmagnetic crystals --- the concept of "species" was introduced, a determination was made of all possible species of full ferroelectrics and of full ferroelastics, and those species were found in which ferroelectricity and ferroelasticity coexist and completely couple with each other. These theories are now extended to cover magnetic crystals in addition to nonmagnetic crystals and to cover the partial in addition to the full. A determination is made of all possible species of full ferromagnetics, partial ferromagnetics, full ferroelectrics, partial ferroelectrics, full ferroelastics, and partial ferroelastics, and it is found out in which of these species two or all of ferromagnetism, ferroelectricity, and ferroelasticity should couple completely or incompletely with each other.
An in-memory object caching framework with adaptive load balancing (2015)

The extreme latency and throughput requirements of modern web applications are driving the use of distributed in-memory object caches such as Memcached. While extant caching systems scale-out seamlessly, their use in the cloud --- with its unique cost and multi-tenancy dynamics --- presents unique opportunities and design challenges.
Formal Enantioselective [4+3] Cycloaddition by a Tandem Diels–Alder Reaction/Ring Expansion (2006)

Abstract The tandem Diels–Alder reaction/ring expansion between cyclopentadiene and unsaturated aldehydes is a highly stereoselective process for the synthesis of bicyclo[3.2.1]octenones, the formal products of a [4+3] cycloaddition. When the initial cycloaddition was conducted in the presence of the chiral Lewis acid catalyst 14 , the bicyclo[3.2.1]octenones were obtained in two steps in 72–85 % yields with up to 96 % ee and>98 % de .
TETRA-ALKYL-SUCCINIMIDES AND THEIR PHARMACOLOGICAL ACTION (1925)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTETRA-ALKYL-SUCCINIMIDES AND THEIR PHARMACOLOGICAL ACTIONArthur W. DoxCite this: J. Am. Chem. Soc. 1925, 47, 5, 1471–1477Publication Date (Print):May 1, 1925Publication History Published online1 May 2002Published inissue 1 May 1925https://pubs.acs.org/doi/10.1021/ja01682a040https://doi.org/10.1021/ja01682a040research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of Capsaicin on Plant Growth (2003)

Capsaicin, a possible allelochemical, caused growth inhibition of roots and shoots of alfalfa (Medicago sativa), cress (Lepidium sativum), lettuce (Lactuca sativa), crabgrass (Digitaria sanguinalis), timothy (Phleum pratense) and ryegrass (Lolium multiflorum), and suppressed their germination. Increasing the dose of capsaicin increased the inhibition. The concentrations for 50 % inhibition of the root growth were 2.7, 0.32, 2.1, 0.27, 0.29 and 0.57 mM for alfalfa, cress, lettuce, crabgrass, timothy and ryegrass, respectively, and the concentrations for 50 % inhibition of the shoot growth were 17, 0.87, 6.7, 2.3, 1.4 and 6.2 mM for alfalfa, cress, lettuce, crabgrass, timothy and ryegrass, respectively. Germination percentage was inhibited 50 % at the concentrations 82, 88, 68, 4.8, 22 and 11 mM for alfalfa, cress, lettuce, crabgrass, timothy and ryegrass, respectively. Thus, effectiveness of capsaicin on the plant growth differed with species and targets, and suggests that capsaicin may act as an allelochemical to other plants.
AMINOALUMINUM HYDRIDE AS NEW REDUCING AGENTS. II. SELECTIVE REDUCTION OF ESTERS OF CARBOXYLIC ACIDS TO ALDEHYDES (1975)

Abstract It was found that esters of carboxylic acids are reduced to the corresponding aldehydes in good yields by diaminoaluminum hydrides such as bis (4-methyl-1-piperazinyl) aluminum hydride and dimorpholinoaluminum hydride at room temperature or under refluxing.
Constrained Layer Damping Treatments for Microstructures (2001)

Abstract This paper presents a bulk micro-machining process to fabricate micro-constrained layer treatments (MCLT) on a microstructure to increase its damping. MCLT consists of a silicon base beam or plate, a viscoelastic photoresist layer, and an aluminum constraining layer. Silicon base beams and plates are fabricated from {100} wafer through EDP etch and BOE etch. A 4.5-μm thick photoresist AZ4620 is deposited on the silicon base beam as the viscoelastic layer. Finally, an aluminum layer is deposited through LPVD as the constraining layer. To evaluate damping performance of MCLT, silicon beams with and without MCLT are subjected to swept-sine excitations by PZT from 0 to 100 kHz. In addition, laser Doppler vibrometer and spectrum analyzer were used to measure frequency response functions (FRF) of the specimen. A finite element analysis identifies the resonance modes measured in FRF. Experimental results confirm that MCLT can increase damping of silicon beams by at least 40%. Significantly larger damping improvement is expected, when the fabrication process is refined.