gebhart/patrepeval huggingface dataset:
Accurate and transferable extended Hückel-type tight-binding parameters (2000)

We show how the simple extended H\"uckel theory can be easily parametrized in order to yield accurate band structures for bulk materials, while the resulting optimized atomic orbital basis sets present good transferability properties. The number of parameters involved is exceedingly small, typically ten or eleven per structural phase. We apply the method to almost fifty elemental and compound bulk phases.
Testing olfaction in a clinical setting. (1989)

Assessment of olfactory functioning at the CCCRC entails a threshold test and an odor identification test that contains eight everyday items. A performance average on the two tests yields a composite score on a scale from 0 (anosmia) to 7 (normosmia). The performance of normal volunteers is stable over most of an individual's life span, but decreases for persons over the age of 65 years. Approximately half the patients with olfactory complaints display anosmia, and the other half have hyposmia. The distribution of scores, however, varies with etiologic category, emplified by the fact that patients with nasal/sinus disease display anosmia more frequently than hyposmia. The tests can determine cause (e.g., improvement of score with corticosteroid treatment in cases of nasal/sinus disease) and can also assess degree of improvement with treatment, such as sinus operation.
Use of contextual information by Bayesian Networks for multi-object tracking in scanning laser range data (2009)

This paper presents a new method to improve the perception of the environment of a vehicle. The aim here is to detect the vehicles using a scanning laser range finder and track the detected objects at each time. This contribution can be considered as an element of a global vehicle-to-vehicle (v2v) surveillance system where the on-board system receives warnings from the other local systems. It allows to extend the effective surveillance field and as a consequence to provide a faster reaction of the vehicle (collision avoidance or mitigation). To deal with this multi-target tracking problem, we focus on the Joint Probabilistic Data Association (JPDA) methods. Their particularity lies in their ability to take into account the probabilistic characteristics of the detector (detection and false alarm probabilities). Whereas in many works the detection probability is set up once, our contribution is to propose a method that dynamically estimates for each object the detection probability using the contextual information modeled by a Bayesian Network (BN-JPDAF).
The world’s largest family with familial atrio-ventricular nodal reentry tachycardia (2015)

We report a three-generation family coming from southeastern region of Poland (Podkarpackie voivodship) with 6 women having normal hearts and presenting with a history of paroxysmal tachycardia with onset of symptoms in the adulthood. Recordings of clinical SVT, dual AVN electrophysiology, induction of typical AVNRT and results of RFCA are available. The history of this family shows the significance of a careful and detailed collection of medical history, and point towards the importance of family screening in AVNRT patients.
Follitropin (FSH) Deficiency in an Infertile Male due to FSHβ Gene Mutation. A Syndrome of Normal Puberty and Virilization but Under-developed Testicles with Azoospermia, Low FSH but High Lutropin and Normal Serum Testosterone Concentrations (1998)

We studied a man who sought medical attention at age 28 years because of infertility in both his first and second marriages. His sexual development appeared to have been normal, with normal puberty and virilization, and normal libido and sexual potency. At examination, his testicles were small and soft; otherwise he had a normal physical appearance. Evaluations revealed azoospermia, undetectable in serum before and after 100 microg of intravenously administered gonadotrophin releasing hormone, but moderately elevated lutropin concentration with a brisk rise after gonadotrophin releasing hormone. The alpha subunit concentration was normal before and after gonadotrophin releasing hormone; that of inhibin B was very low. Analysis of the follitropin beta gene, exon 3, revealed a Cys82 --> Arg mutation (TGT --> CGT). Judging from studies of the biosynthesis of the chorionic gonadotrophin beta subunit one may conclude that inability to form the first intramolecular disulphide bond in the follitropin beta subunit results in an abnormal tertiary structure during follitropin beta biosynthesis with extensive intracellular degradation of the products, inability to associate with the alpha subunit and defective glycosylation, as well as inability to form a biologically active hormone. This first male case of follitropin deficiency thus defines a new syndrome of male infertility.
Parallel volume rendering using binary-swap compositing (1994)

We describe a parallel volume-rendering algorithm, which consists of two parts: parallel ray tracing and parallel compositing. In the most recent implementation on Connection Machine's CM-5 and networked workstations, the parallel volume renderer evenly distributes data to the computing resources available. Without the need to communicate with other processing units, each subvolume is ray traced locally and generates a partial image. The parallel compositing process then merges all resulting partial images in depth order to produce the complete image. The compositing algorithm is particularly effective for massively parallel processing, as it always uses all processing units by repeatedly subdividing the partial images and distributing them to the appropriate processing units. Test results on both the CM-5 and the workstations are promising. They do, however, expose different performance issues for each platform.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
<title>Thermally induced currents and instabilities of photoresponse in PbTe(In)-based films</title> (1999)

The thermally induced currents (TIC) and instabilities of photoresponse in Pb<SUB>1-x-y</SUB>Sn<SUB>x</SUB>Ge<SUB>y</SUB>Te(IN) films on BaF<SUB>2</SUB> substrates have been investigated at temperatures 4.2 < T < 30 K. The temperature T<SUB>M</SUB> corresponding to maximum values of single TIC peaks appears to be extremely low varying from 6 K up to 14 K. The combined effect of lighting and slight heating of the sample from 4.2 K up to approximately 6 K results in photoresponse instabilities depending on the experimental regime. The results are interpreted in terms of thermal excitation of charge carriers from metastable impurity level.
Multiqueue Systems with Nonexhaustive Cyclic Service (1979)

Queuing models with cyclic-type service are applicable for performance studies of polling mechanisms in data communication and switching systems or cyclic scheduling algorithms in real time computers. This paper provides an approximate analysis of the multiqueue system M <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[x]</sup> /G/1 with batch Poisson input, general service times, general overhead (switchover) times, and a single server operating under a cyclic strategy with nonexhaustive service of queues. Based on a new concept of conditional cycle times, the generating function of the stationary probabilities of state, the Laplace-Stieltjes transforms of the delay distributions, and the mean waiting times are derived explicitly for each queue through an imbedded Markov chain approach and an independence assumption. The approximate analytic results are validated by computer simulations. Besides this analysis, a stability criterion is derived for the general case of GI/G/1 systems with cyclic priority service. The paper concludes with a number of studies of the behavior of cyclic queues discovering interesting properties such as the dependence of cycle times and waiting times on the arrival and service process types and on the efficiency of cyclic priorities.
Recombinant carbohydrate and selenomethionyl variants of human choriogonadotropin (1991)

Recombinant human choriogonadotropin and selenomethionyl human choriogonadotropin (rhCG and SehCG) were expressed in baculovirus expression system by coinfection of SF9 insect cells by recombinant viruses, AcMNPV-hCG alpha and AcMNPV-hCG beta containing hCG alpha and hCG beta cDNAs. The expression efficiency of both rhCG and SehCG was quite high. The association of the alpha and beta subunits into a dimer was apparently complete since no detectable amount of rhCG beta was found in the rhCG eluate from the monoclonal hCG beta antibody immunoaffinity column. Both rhCG and SehCG preparations were homogeneous as indicated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and reverse-phase high performance liquid chromatography. The apparent molecular mass of rhCG and SehCG on sodium dodecyl sulfate-polyacrylamide gel electrophoresis under nonreducing conditions was about 38 kDa while under reducing conditions the heterodimer dissociated to yield beta and alpha subunits with molecular masses of 22.5 and 18 kDa, respectively. The carbohydrate analysis of rhCG showing the presence of 2.1, 3.3, 7.38, 4.2, and 27.8 residues of Fuc, GalNAC, GlcNAC, Gal, and Man, respectively, per mole of the hormone was consistent with the presence of 4 N-linked high mannose type carbohydrate hydrate and 4 O-linked simple carbohydrate chains, probably made up of Gal-GalNAC. Despite the altered glycosylation, rhCG demonstrated close similarity to the native urinary hCG in amino acid composition, receptor binding, and in its ability to stimulate cAMP and steroidogenesis. This indicates that there is no specificity of carbohydrate required for biological activity. Furthermore, it implies that the alteration from the complex to high mannose type carbohydrates in rhCG does not affect its proper folding. Finally, amino acid analysis of SehCG showed that 84% of methionine residues in rhCG were replaced by selenomethionine.
Time delay estimation for passive sonar signal processing (1981)

An overview of applied research in passive sonar signal processing estimation techniques for naval systems is presented. The naval problem that motivates time delay estimation is the source state estimation problem. A discussion of this problem in terms of estimating the position and velocity of a moving acoustic source is presented. Optimum bearing and range estimators are presented for the planar problem and related to the optimum time delay vector estimator. Suboptimum realizations are considered together with the effects of source motion and receiver positional uncertainty.
An origami-inspired cargo drone (2017)

Multicopters stand to revolutionize parcel delivery because of their capability to operate in areas with unsuitable road infrastructure and precisely maneuver in cluttered environments. However, current multicopters for delivery can be dangerous for people, and are difficult to store and transport. Safety issues arise because users are exposed to unshielded spinning propellers. Transportation to the place of deployment and storage is often impaired by the large size that is required for heavy lifting. This paper addresses these limitations by proposing the integration of a quadcopter into a foldable protective cage. The cage provides an all-round protective structure that physically separates the propellers from the environment, ensuring the safety of people. The drone and the cage can be easily folded with a single movement, significantly reducing its size for ease of storage and transportation. This design has been validated with a quadcopter that can lift parcels up to 500 g and reduce its storage volume by 92% when folded.
Preparation of Semiconductor Nanoparticle−Polymer Composites by Direct Reverse Micelle Polymerization Using Polymerizable Surfactants (2000)

Metal sulfide semiconductor nanoparticles of CdS and coprecipitated CdS−ZnS, when prepared in reverse micellar systems consisting of cetyl-p-vinylbenzyldimethylammonium chloride (CVDAC), were immobilized via an in situ polymerization of CVDAC, using 2,2‘-azobisisobutyronitrile or visible light irradiation. The nanoparticles were incorporated successfully into the polymerized CVDAC (PCV) and retained their size and quantum size effect. Since PCV can both retain and cover the nanoparticles effectively, the stability of nanoparticles, versus photoirradiation, is improved as compared to CdS-containing polyurea (J. Phys. Chem. B 1999, 103, 10 120), but the photocatalytic activity is suppressed. PCV is soluble in polar solvents and a CdS nanoparticle-containing transparent film can therefore be prepared by means of casting an ethanol solution of CdS−PCV onto a quartz sheet. An Au nanoparticle-containing PCV was also prepared via in situ Au formation and polymerization by visible light irradiation.
Human Neutrophil Elastase: Degradation of Basement Membrane Components and Immunolocalization in the Tissue (1990)

Human neutrophil elastase was purified to homogeneity as two isozymes named E1 and E2. The isozymes degraded Type IV collagen, laminin, fibronectin, and heparan sulfate proteoglycan similarly to each other. The degradation of such basement membrane components by elastase may assist the extravasation of neutrophils in the process of inflammation. Among the substrates tested, only type V collagen, which is susceptible to neutrophil gelatinase, was resistant to elastase. This broad substrate specificity of the enzyme may also contribute to tissue destruction at the sites of inflammation. We produced a monoclonal antibody against the purified enzyme and applied it to immunohistochemical studies. In bronchopneumonia and polyarteritis nodosa, elastase was associated with the cleaved elastic fibers, indicating that the enzyme really destroys tissue in vivo. In the exudates of rheumatoid joint, elastase was stained as diffuse fine granules. Immunohistochemical studies with the monoclonal antibody will provide a complementary way to disclose the mechanism of diseases related to neutrophil infiltration.
Induction of Immunoglobulin Heavy-Chain Transcription through the Transcription Factor Bright Requires TFII-I (2006)

Bright/ARID3a/Dril1, a member of the ARID family of transcription factors, is expressed in a highly regulated fashion in B lymphocytes, where it enhances immunoglobulin transcription three- to sixfold. Recent publications from our lab indicated that functional, but not kinase-inactive, Bruton's tyrosine kinase (Btk) is critical for Bright activity in an in vitro model system, yet Bright itself is not appreciably tyrosine phosphorylated. These data suggested that a third protein, and Btk substrate, must contribute to Bright-enhanced immunoglobulin transcription. The ubiquitously expressed transcription factor TFII-I was identified as a substrate for Btk several years ago. In this work, we show that TFII-I directly interacts with human Bright through amino acids in Bright's protein interaction domain and that specific tyrosine residues of TFII-I are essential for Bright-induced activity of an immunoglobulin reporter gene. Moreover, inhibition of TFII-I function in a B-cell line resulted in decreased heavy-chain transcript levels. These data suggest that Bright functions as a three-component protein complex in the immunoglobulin locus and tie together previous data indicating important roles for Btk and TFII-I in B lymphocytes.
High-Performance Concrete (2025)

Over the past three decades, high-performance concrete (HPC) and ultra-high-performance concrete (UHPC) have emerged as transformative materials in civil engineering and construction. Characterized by their exceptional compressive strength (often exceeding 150 MPa for UHPC), high ductility (strain-hardening behavior under tension), and superior durability, these materials represent a paradigm shift from conventional concrete. The versatility of HPC/UHPC has enabled its adoption in cutting-edge engineering applications. In 3D-printed construction, their rheological propertiestailored through precise control of viscosity and thixotropyallow for layer-by-layer extrusion without slump deformation, enabling complex geometries unachievable with ordinary concrete. For dry concrete construction, HPC/UHPCs rapid hardening and low water-to-binder ratio minimize curing time and reduce shrinkage cracks, which is critical for prefabricated modular systems. In protective engineering, UHPCs high fracture toughness and energy absorption capacity make it ideal for blast-resistant structures, seismic retrofitting, and coastal defenses exposed to chloride ingress. Emerging applications further underscore its transformative potential. Despite the growing body of research focused on HPC/UHPC, numerous challenges and unresolved research gaps persist, necessitating further innovative exploration.
Heparin‐binding outer membrane protein of chlamydiae (2001)

As an intracellular pathogen, the mechanism by which Chlamydia invade eukaryotic cells represents a cornerstone to understanding chlamydial biology. The ability of chlamydiae specifically to bind heparan sulphate or heparin and the association of this ability to bind and enter mammalian host cells was approached by searching experimentally for chlamydial outer membrane proteins that bind heparin. The 60 000 molecular weight cysteine-rich outer membrane complex protein, OmcB, bound heparin. The ability of OmcB to bind heparin was supported by mapping the region of the protein with heparin-binding capacity and demonstrating that an OmcB synthetic 20-mer peptide from this region specifically bound heparin. Surface localization of OmcB was shown using monospecific antisera specific to the 20-mer OmcB peptide that bound the surfaces of elementary bodies (EB) and by heparin-binding peptide cross-linking of EB surface proteins.
Genetically designing a more potent antipancreatic cancer agent by simultaneously co-targeting human IL13 and EGF receptors in a mouse xenograft model (2008)

In vitro studies show that the presence of both ligands on the same bispecific molecule is responsible for the superior activity of DTEGF13. Intratumoural administration showed that DTEGF13 was highly effective in checking aggressive tumour progression in mice. Lack of weight loss in these mice indicated that the drug was tolerated and a therapeutic index exists in an "on target" model in which DTEGF13 is cross-reactive with native mouse receptors.
Amifostine protects against chemotherapy-induced neurotoxicity: an in vitro investigation. (2004)

Amifostine protects against paclitaxel-induced neurotoxicity, but not against vincristine-induced neurotoxicity in this in vitro model. Furthermore, amifostine has potential to reverse already existing cisplatin-induced neurotoxicity. The role of amifostine in the proliferative potential of tumour cells in vitro needs further investigation.
Fast converging subband acoustic echo cancellation using RAP on the WE DSP16A (2002)

The application of row action projections (RAPs) to the problem of acoustic echo cancellation is discussed. It is shown how RAPs, a subset of projections onto convex sets (POCSs) and a generalization of LMS, can be used to further improve the tracking ability of subband acoustic echo canceller (SBAECs). In addition, the RAP algorithm has a useful complexity versus speed-of-convergence tradeoff. That is, RAP can use additional computational resources to speed convergence. This is used to dynamically allocate computational resources among the subband in such a way as to improve the perceptual performance of the SBAEC. The feasibility of this method is demonstrated by sizing it for AT&T's WE DSP16A digital signal processor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Laparoscopic cholecystectomy for acute or gangrenous cholecystitis. (1994)

Over the past 4 years, laparoscopy has become the preferred approach for cholecystectomy in the majority of patients. Most of the early articles described laparoscopic cholecystectomy for chronic cholecystitis or presented only a limited number of patients with an acute process. This paper reviews our experience with laparoscopic cholecystectomy for acute and gangrenous cholecystitis. There were 460 attempted laparoscopic cholecystectomies, including 44 for acute nongangrenous cholecystitis and 24 for gangrenous cholecystitis. The conversion rate to open cholecystectomy was 2.8 per cent for chronic cholecystitis, 13.6 per cent for acute, and 75 per cent for gangrenous cholecystitis. The length of operation for laparoscopic compared with open cholecystectomy for acute cholecystitis was not significantly different. For gangrenous cholecystitis, the laparoscopic approach took significantly longer than the open method. The length of stay for acute cholecystitis was significantly shorter for laparoscopy compared with the open method. There was no significant difference in length of stay for gangrenous cholecystitis. With a conversion rate of 75 per cent, no shorter length of stay, and a significantly longer operation, the use of the laparoscopic approach when gangrenous cholecystitis is suspected should be questioned.
Regulation of Activating Transcription Factor-1 and the cAMP Response Element-binding Protein by Ca2+/Calmodulin-dependent Protein Kinases Type I, II, and IV (1996)

The ability of activating transcription factor-1 (ATF1) or the cAMP response element-binding protein (CREB) to enhance transcription can be stimulated by increases in intracellular Ca2+ concentrations. To identify protein kinases which may mediate the ability of Ca2+ to activate these transcription factors, we compared the ability of constitutively active forms of several Ca2+/calmodulin-dependent protein kinases (CaM kinases) to activate ATF1 or CREB. We find that constitutively active CaM kinase I and IV can activate both ATF1 and CREB. In addition, expression vectors for full-length CaM kinase I and IV were able to augment the ability of Ca2+ influx to activate ATF1 or CREB consistent with a role for these kinases in mediating transcriptional responses to Ca2+ signaling. In contrast, CaM kinase II was unable to activate either ATF1 or CREB. These findings provide a potential mechanism that may permit variation in the ability of ATF1 and CREB to respond to changes in intracellular Ca2+ concentrations depending on differences in the relative concentrations of specific CaM kinases.
Photopolymerizable nanoarray hydrogels deliver CNTF and promote differentiation of neural stem cells (2010)

One of the goals in neural tissue engineering is to be able to direct the repair and replacement of lost cells and tissue. This will likely involve a multifactorial approach that combines cells, an appropriate scaffold, and drug delivery. In many cases, this system will also need to be able to be delivered in a minimally invasive manner. To address these needs, we have developed a new nanoarray scaffold that can deliver a growth factor over a few weeks, is photopolymerizable to permit minimally invasive administration, and supports the encapsulation, migration, and differentiation of cells. As a model system, we have focused on delivering ciliary neurotrophic factor (CNTF) and neural stem cells (NSCs). CNTF has been shown to be neuroprotective in the central nervous system and also directs NSCs to differentiate, suggesting that it may be useful in treating or engineering tissues of the nervous system. However, combining CNTF delivery with a scaffold to support the growth of neural cells and tissue has been challenging. Here CNTF-loaded nanospheres based on poly(D,L-lactic-co-glycolic acid) (PLGA) were surface-modified with acrylated poly(ethylene glycol) (PEG) and crosslinked into a photopolymerizable poly-L-lysine/PEG hydrogel to act as both a tissue engineering scaffold and a drug delivery system. When NSCs were encapsulated in this CNTF-loaded construct, we observed high survival rates and significant differentiation to mature phenotypes. This allows us to tailor the microenvironment to engineer tissues in new ways.