gebhart/patrepeval huggingface dataset:
OSTEOSARCOMA ABOUT THE KNEE: FUNCTIONAL OUTCOME AND GAIT ANALYSIS OF LIMB SALVAGE PROCEDURES (2003)

The purpose of the study was to evaluate the functional outcome of different limb salvage procedures for osteosarcoma about the knee. A selection of patients who have undergone limb salvage procedures for osteosarcoma about the knee were invited to join the study. Medical and operation notes were reviewed along with recent radiographs of the involved limb. Patients completed the Musculoskeletal Tumour Society functional questionnaire and underwent a gait analysis assessing walking and running. Most patients had stage 2B osteosarcoma involving either the proximal tibia or distal femur. Limb salvage procedures included arthrodesis, allograft reconstruction, endoprosthesis and rotationplasty. All patients scored highly (> 70 %) on the MSTS questionnaire except the arthrodesis that scored 57 %. The gait analysis revealed some subtle changes with a quadriceps-sparing gait in the endoprosthesis, mild foot drop in the proximal tibial allograft and a lateral lean of the trunk over the ipsilateral limb in the rotationplasty. The arthrodesis had an obvious straight leg gait with subtle pelvic hiking to assist foot clearance. While analysis of walking was close to normal most patients were unable to obtain a double float and run. This study shows that limb salvage procedures tailored to each individual case can result in an excellent functional outcome with close to normal gait and high MSTS scores.
Viewpoint: Between Classroom and Boardroom (1975)

"Viewpoint: Between Classroom and Boardroom." Change: The Magazine of Higher Learning, 7(8), pp. 9–62
The Formation of Mixed Magnesium‐Aluminum Hydroxides In Soil Materials (1970)

Abstract Potentiometric titration curves show a buffer region in the vicinity of pH 8.2 to 8.5 when soil materials, which contain reactive forms of Al, are titrated in a Mg solution. This buffering is due to the formation of mixed Mg‐Al hydroxide. The product formed during the titration of gibbsite in 0.2 N MgCl 2 solution was identified as mixed Mg‐Al hydroxide by X‐ray diffraction analysis. The buffer region also appears when allophane, Al sesquioxide, and clay with exchangeable Al are titrated in Mg solutions. The reaction with exchangeable Al and Al sesquioxide is rapid, but the reaction requires several hours and even days with gibbsite and allophane. It is concluded that soils containing these and possibly other forms of Al, when raised to alkaline pH levels, can remove Mg from the soil solution by precipitation of mixed Mg‐Al hydroxide.
Glaucoma Gene Provides Light at the End of the Tunnel (1997)

Because the eye disease glaucoma develops so insidiously, it blinds almost 12,000 people every year in the United States alone. Now, researchers report in this issue ( p. 668 ) that they have identified the gene at fault in juvenile glaucoma—the first time a specific gene has been linked to the condition. The discovery may aid in the diagnosis of glaucoma and provide clues to how it causes a buildup of pressure in the eye, which is thought to lead to blindness by irreversibly damaging the optic nerve.
Pattern Recognition by Convolution Polynomial (1974)

Pattern recognition is considered as a mapping from the set of all inputs to the numbers 0 to 1. The inputs are treated as vectors. A topological group algebra over the vector space is described. The input is treated as avariable in a polynomial of that group algebra. A correspondence between inputs and numbers is established. This correspondence is used to prove that the polynomials in the algebra can represent a solution to any pattern recognition problem. When the coefficients of the polynomial are suitably chosen vectors, the natural topology of the input vector space is preserved. The importance of this approach as a basis for a completely general efficient parallel process, and practically realizable pattern recognizing machine is presented. The concept may be realized by a modular parallel process type of machinery.
Comparison of nearest-neighbor-search strategies and implementations for efficient shape registration (2012)

The Iterative Closest Point (ICP) Algorithm is one of the most popular approaches to shape registration currently in use. At the core of ICP is the computationally-intensive determination of nearest neighbors (NN). As of now there has been no comprehensive analysis of competing search strategies for NN. This paper compares several libraries for nearest neighbor search (NNS) on both simulated and real data with a focus on shape registration. In addition, we present a novel efficient implementation of NNS via k-d trees as well as a novel algorithm for NNS in octrees.
Let there be chip—towards rapid prototyping of microfluidic devices: one-step manufacturing processes (2011)

Microfluidics is an evolving scientific field with immense commercial potential: analytical applications, such as biochemical assay development, biochemical analysis and biosensors as well as chemical synthesis applications essentially require microfluidics for sample handling, treatment or readout. A number of techniques are available to create microfluidic structures today. On industrial scale replication techniques such as injection molding are the gold standard whereas academic research mostly focuses on replication by casting of soft elastomers such as polydimethylsiloxane (PDMS). Both of these techniques require the creation of a replication master thus creating the microfluidic structure only in the second process step—they can therefore be termed two-(or multi-)step manufacturing techniques. However, very often the number of pieces to be created of one specific microfluidic design is low, sometimes even as low as one. This raises the question if two-step manufacturing is an appropriate choice, particularly if short concept-to-chip times are required. In this case one-step manufacturing techniques that allow the direct creation of microfluidic structures from digital three-dimensional models are preferable. For these processes the number of parts per design is low (sometimes as low as one), but quick adaptation is possible by simply changing digital data. Suitable techniques include, among others, maskless or mask based stereolithography, fused deposition molding and 3D printing. This work intends to discuss the potential and application examples of such processes with a detailed view on applicable materials. It will also point out the advantages and the disadvantages of the respective technique. Furthermore this paper also includes a discussion about non-conventional manufacturing equipment and community projects that can be used in the production of microfluidic devices.
Fluorine- and rhenium-containing geldanamycin derivatives as leads for the development of molecular probes for imaging Hsp90 (2012)

Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone responsible for protein quality control in cells. Hsp90 has been shown to be overexpressed in many human cancers. This has prompted extensive research on Hsp90 inhibitors as novel anticancer agents and, more recently, the development of molecular probes for imaging Hsp90 expression in vivo. This work describes the development of various fluorine-containing and rhenium-containing geldanamycin derivatives as leads for the development of corresponding (18)F-labeled and (99m)Tc-labeled PET and SPECT probes for molecular imaging of Hsp90 expression. All compounds were evaluated in an in vitro ATPase activity assay using Hsp90 isoform Hsp82p. Fluorobenzoylated geldanamycin derivative 5 displayed comparable inhibitory potency like parent compound geldanamycin.
Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): Consensus document of the committee for the Classification of Vestibular Disorders of the Bárány Society (2017)

This paper presents diagnostic criteria for persistent postural-perceptual dizziness (PPPD) to be included in the International Classification of Vestibular Disorders (ICVD). The term PPPD is new, but the disorder is not. Its diagnostic criteria were derived by expert consensus from an exhaustive review of 30 years of research on phobic postural vertigo, space-motion discomfort, visual vertigo, and chronic subjective dizziness. PPPD manifests with one or more symptoms of dizziness, unsteadiness, or non-spinning vertigo that are present on most days for three months or more and are exacerbated by upright posture, active or passive movement, and exposure to moving or complex visual stimuli. PPPD may be precipitated by conditions that disrupt balance or cause vertigo, unsteadiness, or dizziness, including peripheral or central vestibular disorders, other medical illnesses, or psychological distress. PPPD may be present alone or co-exist with other conditions. Possible subtypes await future identification and validation. The pathophysiologic processes underlying PPPD are not fully known. Emerging research suggests that it may arise from functional changes in postural control mechanisms, multi-sensory information processing, or cortical integration of spatial orientation and threat assessment. Thus, PPPD is classified as a chronic functional vestibular disorder. It is not a structural or psychiatric condition.
Dynamic Adaptive Streaming based on Deep Reinforcement Learning (2019)

Abstract Dynamic adaptive streaming over HTTP (DASH) is the dominant technology of multimedia delivery over the Internet. In DASH system, adaptive bitrate (ABR) algorithms running on client-side video player are the key to improve user quality of experience (QoE). However, most existing ABR algorithms employ fixed control rules to make bitrate decisions based on throughput, playback buffer size, or a combination of the two. As a result, their performance in the complicated and fluctuant network environment is incompetent. In this paper, we propose QRL, a bitrate adaptation approach based on deep reinforcement learning. QRL uses double Q-Learning, an enhanced Q-Learning method. After training the neural network model, the algorithm can select proper bitrates for future video segments based on all the information collected by client during the video playback process. Simulation results show that QRL achieves better performance than other algorithms.
Binding of thrombin to cultured human endothelial cells. Nonequilibrium aspects. (1980)

The long-term incubation of 125I-thrombin with cultured human endothelial cells is studied and compared to the previously described rapid equilibrium binding in this system (Awbrey, B. J., Hoak, J. C., and Owen, W. G. (1979) J. Biol. Chem. 254, 4092-4095). Following rapid initial binding of thrombin, a much slower association of thrombin with endothelium is seen. As opposed to equilibrium binding, this process is 1) irreversible, 2) active-site specific, and 3) associated with covalent linkage to an Mr 30,000 protein. In addition this nonequilibrium binding appears unrelated to high-affinity equilibrium binding since blocking the high-affinity binding sites with diisopropylphosphoryl thrombin has no effect on nonequilibrium binding. The physiological role of this process is unknown.
Caveolin-1-dependent β1 integrin endocytosis is a critical regulator of fibronectin turnover (2008)

beta1 integrins are major cell surface receptors for fibronectin. Some integrins, including beta1 integrins, are known to undergo constitutive endocytosis and recycling. Integrin endocytosis/recycling has been implicated in the regulation of cell migration. However, the mechanisms by which integrin endocytosis/recycling regulates cell migration, and other biological consequences of integrin trafficking are not completely understood. We previously showed that turnover of extracellular matrix (ECM) fibronectin occurs via receptor-mediated endocytosis. Here, we investigate the biological relevance of beta1 integrin endocytosis to fibronectin matrix turnover. First, we demonstrate that beta1 integrins, including alpha5beta1 play an important role in endocytosis and turnover of matrix fibronectin. Second, we show that caveolin-1 constitutively regulates endocytosis of alpha5beta1 integrins, and that alpha5beta1 integrin endocytosis can occur in the absence of fibronectin and fibronectin matrix. We also show that downregulation of caveolin-1 expression by siRNA results in marked reduction of beta1 integrin and fibronectin endocytosis. Hence, caveolin-1-dependent beta1 integrin and fibronectin endocytosis plays a critical role in fibronectin matrix turnover, and may contribute to abnormal ECM remodeling that occurs in fibrotic disorders.
Histone modifications as markers of cancer prognosis: a cellular view (2007)

Alterations in modifications of histones have been linked to deregulated expression of many genes with important roles in cancer development and progression. The effects of these alterations have so far been interpreted from a promoter-specific viewpoint, focussing on gene–gene differences in patterns of histone modifications. However, recent findings suggest that cancer tissues also display cell–cell differences in total amount of specific histone modifications. This novel cellular epigenetic heterogeneity is related to clinical outcome of cancer patients and may serve as a valuable marker of prognosis.
Characterization of multimetallic grid‐type complexes by electrospray mass spectrometry (2001)

The self-assembly of the terdentate ligands 1a-h, based on terpyridine-like binding sites, with octahedrally coordinated metal ions, such as Fe(II), Co(II), Cu(II), Zn(II), Cd(II), Hg(II) and Pb(II), leads to the formation of the supramolecular grid-type complexes 2a-c(M(II)), 3d-g(M(II)) and 4h(M(II)). The structures and compositions of these coordination complexes in solution were deduced from electrospray mass spectrometry (ESMS) measurements. The results agree with the data available from x-ray radiocrystallography in the solid state and/or NMR spectroscopy in solution. ESMS may be applied in cases where other methods are difficult to use or inconclusive. This study stresses the power of ESMS in supramolecular chemistry.
Intravenous injection of a foamy virus vector to correct canine SCID-X1 (2014)

Current approaches to hematopoietic stem cell (HSC) gene therapy involve the collection and ex vivo manipulation of HSCs, a process associated with loss of stem cell multipotency and engraftment potential. An alternative approach for correcting blood-related diseases is the direct intravenous administration of viral vectors, so-called in vivo gene therapy. In this study, we evaluated the safety and efficacy of in vivo gene therapy using a foamy virus vector for the correction of canine X-linked severe combined immunodeficiency (SCID-X1). In newborn SCID-X1 dogs, injection of a foamy virus vector expressing the human IL2RG gene resulted in an expansion of lymphocytes expressing the common γ chain and the development of CD3(+) T lymphocytes. CD3(+) cells expressed CD4 and CD8 coreceptors, underwent antigen receptor gene rearrangement, and demonstrated functional maturity in response to T-cell mitogens. Retroviral integration site analysis in 4 animals revealed a polyclonal pattern of integration in all dogs with evidence for dominant clones. These results demonstrate that a foamy virus vector can be administered with therapeutic benefit in the SCID-X1 dog, a clinically relevant preclinical model for in vivo gene therapy.
The effect of loading and material on the biomechanical properties and vitality of bovine cartilage in vitro (2011)

Based on the results, PU seems to be more compatible material than surgical steel in contact with living cartilage. Because of a large variation in the quality of bovine cartilage material from different animals, special care is necessary when selecting specimens to guarantee reliable and reproducible results.
Wood and Cellulosic Chemistry, Revised, and Expanded (2000)

This text details the principal concepts and developments in wood science, chemistry and technology. It includes new chapters on the chemical synthesis of cellulose and its technology, preservation of wood resources and the conservation of waterlogged wood.
High-speed ultrawideband compressed sensing of sparse radio frequency signals (2014)

Using chirp processing of ultrafast laser pulses to perform pseudorandom measurements for compressed sensing, we successfully reconstruct multi-tone sparse-frequency microwave signals with an effective sampling rate well beyond the electronic limit.
Structure and mechanism of ATP-binding cassette transporters (2008)

ATP-binding cassette (ABC) transporters constitute a large superfamily of integral membrane proteins that includes both importers and exporters. In recent years, several structures of complete ABC transporters have been determined by X-ray crystallography. These structures suggest a mechanism by which binding and hydrolysis of ATP by the cytoplasmic, nucleotide-binding domains control the conformation of the transmembrane domains and therefore which side of the membrane the translocation pathway is exposed to. A basic, conserved two-state mechanism can explain active transport of both ABC importers and ABC exporters, but various questions remain unresolved. In this article, I will review some of the crystal structures and the mechanistic insight gained from them. Future challenges for a better understanding of the mechanism of ABC transporters will be outlined.
Integrated nutrient management in rainfed castor (Ricinus communis) (2002)

A field experiment was undertaken to assess the effect of conjuctive use of organic inorganic and biofertilizers, or the productivity of castor under rainfed conditions.The results indicated that applications of 50% R.O.F. (recommended dose of fertilizer) in conjuection with Azospirillum seed treatment and application of 25% N through F.Y.M. + Phosphours soulbilizing bacteria gave higher yield followed by 50% R.O.F. + Azosipirillum + 25% N through F.Y.M. than the rest of the treatments. It can be concluded from the present study that organic and inorganic fertilizers cannot completely substitute bio-fertilizers. However, conjuctive use of these fertilizers can sustain the productivity.
Drug Therapy of Inflammatory Bowel Disease (1983)

Although the etiology of inflammatory bowel disease is unknown and specific therapy is unavailable, enough information on existing empiric agents is available to allow rational therapy. These agents include sulfasalazine, steroids, immunosuppressive drugs, metronidazole and cholestyramine. Sulfasalazine is a two-part molecule that depends on bacterial cleavage in the colon to deliver locally acting 5-aminosalicylate, whose mechanism of action may relate to inhibition of prostaglandin synthesis. The other half of the molecule, sulfapyridine, is responsible for most of the side effects of the drug. While the efficacy of sulfasalazine in the treatment and prevention of attacks of ulcerative colitis is well established, its use in Crohn's disease appears to be limited to patients with active colitis and ileo-colitis. Sulfasalazine is of major benefit in preventing relapses in patients with ulcerative colitis in remission. New formulations of 5-aminosalicylate may allow delivery of the apparently active moiety to the small bowel and colon without concomitant sulfapyridine toxicity. Corticosteroids are highly effective in acute attacks of ulcerative colitis and Crohn's ileitis and ileo-colitis; the mechanism of antiinflammatory action remains speculative. However, maintenance therapy with steroids is ineffective in preventing relapses or recurrent attacks of either ulcerative colitis or Crohn's disease. Steroid enemas allow topical administration to patients with distal colitis and proctitis with few systemic side effects. In children with growth failure associated with active Crohn's disease, amelioration by steroid therapy may actually restore normal growth. Immunosuppressive agents such as azathioprine and 6-mercaptopurine are of little value in active Crohn's disease when administered alone; however, in combination with other agents they may help diminish steroid dose, close fistulae and prevent relapse. Their mode of action likely depends on long-term cytostatic effects on immune effector cells. Concern for leukopenia and the development of late malignancy has limited their use to patients not responding to other therapies. Metronidazole, an antimicrobial agent that is effective against anaerobes, has recently been shown useful in Crohn's disease involving the colon and perianal area. Its mechanism of action is uncertain, but may be related to its antibacterial actions on anaerobes. Cholestyramine can be successfully used to control bile salt-induced diarrhea in Crohn's patients with terminal ileal resections. Effective drug therapy of inflammatory bowel disease is only part of a total program of management including reassurance, frequent explanation, well-timed use of surgery, and an understanding physician.
Asymmetric Total Synthesis of (−)-Jorunnamycins A and C and (−)-Jorumycin from <scp>l</scp>-Tyrosine (2013)

Three renieramycin-type antitumor alkaloids, (-)-jorunnamycins A (1) and C (2) and (-)-jorumycin (3), have been synthesized by a new convergent approach, which features a highly regio- and stereoselective Pictet-Spengler cyclization to couple the isoquinoline and the trisubstituted phenylalaninol partners. This synthetic strategy opens an economical access to these important antitumor alkaloids with high yields: (-)-jorunnamycin A, as a common precursor to other renieramycin-type alkaloids and their analogues, is obtained with 18.1% overall yield from l-tyrosine.
Keystroke-Based User Identification on Smart Phones (2009)

Abstract. Smart phones are now being used to store users ’ identities and sensitive information/data. Therefore, it is important to authenticate legitimate users of a smart phone and to block imposters. In this paper, we demonstrate that keystroke dynamics of a smart phone user can be translated into a viable feature set for accurate user identification. To this end, we collect and analyze keystroke data of 25 diverse smart phone users. Based on this analysis, we select six distinguishing keystroke features that can be used for user identification. We show that these keystroke features for different users are diffused and therefore a fuzzy classifier is well-suited to cluster and classify them. We then optimize the front-end fuzzy classifier using Particle Swarm Optimizer (PSO) and Genetic Algorithm (GA) as back-end dynamic optimizers to adapt to variations in usage patterns. Finally, we provide a novel keystroke dynamics based PIN verification mode to ensure information security on smart phones. The results of our experiments show that the proposed user identification system has an average error rate of 2 % after the detection mode and the error rate of rejecting legitimate users is dropped to zero after the PIN verification mode. We also compare error rates (in terms of detecting both legitimate users and imposters) of our proposed classifier with 5 existing state-of-the-art techniques for user identification on desktop computers. Our results show that the proposed technique consistently and considerably outperforms existing schemes. 1
Computing multi-colored polygonal masks in pipeline architecture and its application to automated visual inspection (1987)

New techniques for computing multicolored polygonal masks for image analysis and computer vision applications are presented. The procedures do not require random access of the image memory. They are based on efficient generation of coordinate-reference images (ramps) and other simple general purpose architectural features such as look-up tables. The techniques presented are, unlike their predecessors, highly parallel and can be efficiently implemented in existing pipeline image processors. In addition, we show an architecture in the form of functional building blocks that will enable us to compute polygonal and other masks much faster than commercially available pipeline systems. Extensive motivation and use of the new algorithms for digital visual inspection applications are given throughout.