gebhart/patrepeval huggingface dataset:
Identification of sea urchin sperm adenylate cyclase. (1990)

Calmodulin (CaM) affinity chromatography of a detergent extract of sea urchin sperm yielded approximately 20 major proteins. One of these proteins, of Mr 190,000, was purified and used to immunize rabbits. After absorption with living sperm, the serum reacted monospecifically on one- and two-dimensional Western immunoblots with the Mr 190,000 protein. The anti-190-kD serum inhibited 94% of the adenylate cyclase (AC) activity of the CaM eluate. An immunoaffinity column removed 95% of the AC activity, and the purified (but inactive) Mr 190,000 protein was eluted from the column. The antiserum also inhibited 23% of the activity of bovine brain CaM-sensitive AC and 90% of the activity of horse sperm CaM-sensitive AC. These data support the hypothesis that the Mr 190,000 protein is sea urchin sperm AC. Although this AC bound to CaM, it was not possible to demonstrate directly a Ca2+ or CaM sensitivity. However, two CaM antagonists, calmidazolium and chlorpromazine, both inhibited AC activity, and the inhibition was released by added CaM, suggesting the possibility of regulation of this AC by CaM. Indirect immunofluorescence showed the Mr 190,000 protein to be highly concentrated on only the proximal half of the sea urchin sperm flagellum. This asymmetric localization of AC may be important to its function in flagellar motility. This is the first report of the identification of an AC from animal spermatozoa.
Rectifying metal-polymer contacts formed by melt processing (1990)

Rectifying contacts between aluminum, indium, or titanium and a solution and melt processable conducting polymer, poly(3-octylthiophene) have been formed by melt processing. The contacts are formed by heating a metal/polymer/metal structure to the melting point of the polymer and then pressing the metals to the melted polymer until adhesion is achieved, whereupon the whole structure is cooled to room temperature. Comparison of the current-voltage and capacitance-voltage characteristics of a melt processed device and a device manufactured by metal sputtering shows that no significant differences exist between these structures.
AN EXAMINATION OF DECISION -MAKING IN IT PROJECTS FROM RATIONAL AND NATURALISTIC PERSPECTIVES (2007)

This exploratory research examines the decision-making processes of experienced IT project managers at the initial start-up stage of their projects and at key decision points during project execution. The focus is on the decision-making related to potential problems (risks) at the start, and materialized problems during the course of the project. Decision processes are viewed from the perspective of two contrasting theories of decision-making – the rational method and Naturalistic Decision-Making theory – in order to investigate how well each of these theories describes actual practice. Findings show an intertwining of rational and naturalistic modes of decision-making, and a possible link was revealed between the use of rational methods and fewer subsequent problems. In particular, greater reliance on the naturalistic approach may contribute to poor project performance in terms of management of contingencies and expectancies about client relations.
Total and Individual Coronary Artery Calcium Scores as Independent Predictors of Mortality in Hemodialysis Patients (2010)

Many traditional and nontraditional risk factors contribute to vascular calcification among maintenance hemodialysis (MHD) patients. It is not clear whether coronary artery calcification (CAC) delineates a higher mortality risk independent of known risk factors. We examined 6-year (10/2001-9/2007) survival of 166 MHD patients, aged 53 +/- 13 years, with baseline CAC scores. Patients were grouped into four CAC groups: 0, 1-100, 101-400, and 400+. The 101-400 and 400+ groups were associated with a significantly higher adjusted risk of death than CAC 0 with hazard ratios (HR) 8.5 (95% CI: 1.1-48.1, p = 0.02) and 13.3 (95% CI: 1.3-65.1, p = 0.01), respectively, independent of demographics, comorbidity, lipids and other cardiovascular risks, surrogates of bone disease, nutritional and inflammatory markers and dialysis dose. Total CAC [HR 6.7 (1.1-21.5, p = 0.03)] followed by the presence of CAC in the left main [4.6 (2.2-9.8, p = 0.001)] and left anterior descending artery [4.3 (2.1-14.2, p = 0.001)] were strong independent predictors of mortality even after adjusting for above covariates. Total and vessel-specific CAC predict mortality in MHD patients independent of traditional and nontraditional risk factors.
Differential Impact of Ultrasonically Nebulized Versus Tracheal-instilled Surfactant on Ventilation-Perfusion (V <scp>A</scp> /Q) Mismatch in a Model of Acute Lung Injury (2000)

In a model of acute lung injury, established by saline lavage of isolated perfused rabbit lungs, the effect of ultrasonic surfactant nebulization on gas exchange was compared with that of tracheal instillation, assessed by the multiple inert gas elimination technique (MIGET). Ultrasonic aerosolization provided particles with a mass median aerodynamic diameter of 4.5 microm (geometric SD, 2.3), the pulmonary deposition of which was monitored on-line by a laserphotometric technique. Under baseline conditions, a narrow unimodal distribution of ventilation and perfusion with shunt-flow ranging below 2% and absence of perfusion of low V A/Q (0.01 < V A/Q < 0.1) areas was noted throughout. This physiological V A/Q matching was not affected by lung deposition of 8.6 mg surfactant/kg body weight (bw), forwarded by 1 h ultrasonic nebulization. In contrast, tracheal bolus injection of 80 mg/ kg bw surfactant in control lungs provoked the appearance of low V A/Q areas (maximum approximately 13% of perfusion) and shunt flow (4 to 6%), in addition to marked ventilation-perfusion mismatch (broadening of perfusion and ventilation distribution) in the midrange V A/Q regions. The saline lavage procedure caused progressive development of shunt flow ( approximately 22%) and perfusion of low V A/Q areas ( approximately 7%), associated with severe V A/Q mismatch. "Rescue" tracheal instillation of 80 mg/kg bw surfactant in lavaged lungs reduced the shunt-flow to approximately 4%, but increased the perfusion of low V A/Q areas to 10 to 14%; V A/Q mismatch in the midrange V A/Q regions was not improved. Ultrasonic deposition of 8.8 mg surfactant/kg bw in the injured lungs reduced the shunt flow to approximately 7% and the perfusion of low V A/Q areas to < 2%, coincident with improvement of V A/Q matching in the midrange V A/Q areas. We conclude that low doses of ultrasonically delivered natural surfactant are similarly effective as "conventional" doses of tracheal-instilled surfactant in reducing shunt flow in an acute lung injury model, but exert more advantageous effects on ventilation perfusion matching.
Introduction to Liquid Phase Epitaxy (2007)

This chapter contains sections titled: General aspects of liquid phase epitaxy Epitaxial growth modes, growth mechanisms and layer thicknesses The substrate problem Conclusions Acknowledgements References
Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro (2019)

Even with access to sufficient nutrients and atmosphere, Plasmodium falciparum can barely be cultured at maximum growth capacity in vitro conditions. Because of this behavior, it has been suggested that P. falciparum has self-regulatory mechanisms in response to density stress. Only recently has this process begun to be acknowledged and characteristics of a programmed cell death been assigned to the parasite at high parasitaemia in vitro cultures. In searching for death signals within the parasite community, we have found that extracellular vesicles (EVs) of P. falciparum from high parasitaemia cultures are able to induce programmed cell death processes in the population. A comparative proteomic analysis of EVs from low (EV<sub>L</sub>) and high (EV<sub>H</sub>) parasitaemia cultures was conducted, pointing to lactate dehydrogenase from P. falciparum (PfLDH) as the only parasite protein overexpressed in the later. Although the major function of P. falciparum lactate dehydrogenase (PfLDH) is the conversion of pyruvate to lactate, a key process in the production of energy in most living organisms, we investigated its possible role in the mechanism of parasite density control by intercellular signaling, given that PfLDH had already been listed as a component of extracellular vesicles of P. falciparum. In this study we present evidence of the EV-associated PfLDH regulation of parasite population by inducing apoptosis in highly parasitized cultures.
Prenatal diagnosis of sex in cattle by amniocentesis (1975)

A method for the aspiration of amniotic fluid from pregnant cows at 70 to 1000 day gestation and the subsequent cultivation of amniotic cells in vitro is described. The unit for aspirating amniotic fluid includes a sterile Plexitron tubing fitted with a 60 ml syringe on one end and a 12 in needle ("18 gauge) partially encased in a 6 inch AI pipette on the other. Aspiration of fluid is accomplished through the vaginal route by piercing the dorsal fornix and chromosome analysis is performed on amniotic cells after cultivation in vitro for four to seven days. This method, which is simple and accurate, provides a safe diagnostic procedure for the prenatal detection of sex and cytogenetic defects in cattle.
An integrated subchannel scheduling algorithm for adaptive modulation and coding (AMC) MIMO-OFDM wireless systems (2005)

We develop an integrated subchannel scheduling algorithm to maximize the system throughput while guaranteeing minimum data rate requirements for multimedia users in multiuser MIMO-OFDM systems downlink transmission utilizing adaptive modulation and coding (AMC) with limited channel state information feedback. By using the integrated subchannel scheduling, we apply the mathematical equivalence between antennas and subcarriers in the analysis, getting multiple parallel transmit subchannels, and then evaluating the channel state from the viewpoint of receivers. Joint space-frequency diversity as well as multiuser diversity is exploited simultaneously by the subchannel allocation algorithm. A modified proportional fair scheduling is proposed and a fast algorithm for more practical implementation is also proposed. By numerical examples, the system throughput and fairness superiority of our scheduling scheme are verified.
SpecScan: A Utility Program for Generating Numerical Data from Printed Forms of Spectra or Other Signals (2003)

SpecSpan is a utility program for Microsoft Windows that generates numerical data from printed spectra or other plots found as figures in text, chart recordings, or freehand drawings. SpecScan can process bitmap (.BMP) images of such figures and drawings. After a brief interaction with the user, it generates and exports numerical data as Excel (.XLS) or text (.TXT) files.
Hydrogenation of low-pressure chemical-vapor-deposition silicon thin films (1987)

Dark conductivity and photoconductivity of low pressure chemical-vapor-deposition silicon thin films (amorphous and microcrystalline) and the effect of hydrogenation are reported. The effectiveness of hydrogenation was observed to depend on the dopant concentration present in the film, on the structure of the silicon network, and on the hydrogenation process itself, such as the dose and energy spectrum of the hydrogen beam.
On the Necessity of Accurate IEEE 802.11P Models for IVC Protocol Simulation (2012)

In the scientific community, Inter-Vehicle Communication (IVC) protocols are frequently evaluated using simulation techniques, often using variants of WiFi stacks instead of IEEE 802.11p, which constitutes the basis for the new DSRC/WAVE standard. We discuss the necessity of using accurate WAVE models based on an extensive set of simulation experiments using: an IEEE 802.11b model, an IEEE 802.11b model tweaked to work in the same frequency range and using similar timings like IEEE 802.11p, as well as a fully featured channel hopping WAVE model. Even though, intuitively, the use of the different protocols will lead to a different network behavior, to the best of our knowledge, there has been no qualitative and quantitative evaluation or comparison of both worlds. According to our results, we can conclude that the simple WiFi model may indeed be used, but only for extremely sparse scenarios - this is exactly what has been validated using field tests. In denser traffic scenarios there is a significant deviation of the protocol behavior between WiFi (and its adapted variant) compared to WAVE. Thus, especially in dense scenarios, the application behavior is strongly influenced if simulated with the wrong model - leading to unrealistic results.
Current Options for the Topical Treatment of Acne Vulgaris (1997)

The etiopathogenesis of acne vulgaris, a common disorder of youth and adolescence, includes four primary processes: hyperkeratinization (plugging) of the pilosebacous follicles, increased testosterone levels, bacterial colonization with Propionibacterium acnes, and inflammation. No single agent has yet been developed that addresses all of these factors. Combination regimens, therefore, which usually include an antibiotic and an agent to reduce follicular plugging, have become the mainstay of treatment. Despite a relative dearth of new treatments for almost a decade, recent research has produced a number of new significant oral and topical agents. Azelaic acid, a naturally occurring dicarboxylic acid analogue, has shown promise, and a group of retinoids that include adapalene, tazarotene, and reformulations of tretinoin represent new and forthcoming agents for topical treatment of acne vulgaris. Some studies indicate that several of these agents are associated with less skin irritation than previous formulations while they retain potent comedolytic activity. Adapalene also possesses significant anti-inflammatory activity.
A Novel Confidence-Based Framework for Multiple Expert Decision Fusion (1998)

A novel confidence-based parallel multiple expert decision combination framework is introduced. The traditional approaches to parallel multiple source decision fusion either take no account of the confidence of each decision by each participating expert in the combined framework or only exploit the confidences associated with each decision. But it is entirely possible to incorporate more additional ap rioriinformation in the form of various confidence indices that can be estimated from the performances of various participating experts. The confidence-based parallel multiple expert decision combination framework proposed here addresses this shortcoming. Very encouraging results have been obtained by implementing this proposed framework in combining decisions of multiple experts applied to the problem of handwritten and machine printed character recognition.
LTR real‐time PCR for HIV‐1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01) (2008)

HIV-1 diagnosis in babies born to seropositive mothers is one of the challenges of HIV epidemics in children. A simple, rapid protocol was developed for quantifying HIV-1 DNA in whole blood samples and was used in the ANRS French pediatric cohort in conditions of prevention of mother-to-child transmission. A quantitative HIV-1 DNA protocol (LTR real-time PCR) requiring small blood volumes was developed. First, analytical reproducibility was evaluated on 172 samples. Results obtained on blood cell pellets and Ficoll-Hypaque separated mononuclear cells were compared in 48 adult HIV-1 samples. Second, the protocol was applied to HIV-1 diagnosis in infants in parallel with plasma HIV-RNA quantitation. This prospective study was performed in children born between May 2005 and April 2007 included in the ANRS cohort. The assay showed good reproducibility. The 95% detection cut-off value was 6 copies/PCR, that is, 40 copies/10(6) leukocytes. HIV-DNA levels in whole blood were highly correlated with those obtained after Ficoll-Hypaque separation (r = 0.900, P < 0.0001). A total of 3,002 specimens from 1,135 infants were tested. The specificity of HIV-DNA and HIV-RNA assays was 100%. HIV-1 infection was diagnosed in nine infants before age 60 days. HIV-DNA levels were low, underlining the need for sensitive assays when highly active antiretroviral therapy (HAART) has been given. The performances of this HIV-DNA assay showed that it is adapted to early diagnosis in children. The results were equivalent to those of HIV-RNA assay. HIV-DNA may be used even in masked primary infection in newborns whose mothers have received HAART.
Gas Chromatography Use of Liquid-Modified Solid Adsorbent to Resolve C<sub>5</sub> and C<sub>6</sub> Saturates (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT Gas Chromatography Use of Liquid-Modified Solid Adsorbent to Resolve C5 and C6 SaturatesF. T. Eggertsen, H. S. Knight, and Sigurd. GroenningsCite this: Anal. Chem. 1956, 28, 3, 303–306Publication Date (Print):March 1, 1956Publication History Published online1 May 2002Published inissue 1 March 1956https://pubs.acs.org/doi/10.1021/ac60111a004https://doi.org/10.1021/ac60111a004research-articleACS PublicationsRequest reuse permissionsArticle Views67Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Polymerisationsreaktionen an Adsorptionsschichten von Feststoffpulvern (1969)

Abstract Die Adsorption von polaren organischen Verbindungen wie Carbonsäuren an oxidische Feststoffoberflächen führt zu Adsorptionsschichten, die nicht vollständig desorbierbar sind. Bestehen die irreversibel adsorbierten Schichten aus copolymerisationfähigen oder polymerisationsinitiierenden Verbindungen, so können die Adsorptionsschichten mit einer an sie grenzenden copolymerisationsfähigen Phase copolymerisieren oder eine Polymerisation auslösen. Auf diese Weise können Polymere hergestellt werden, die eine große Haftfestigkeit auf der Feststoffoberfläche besitzen.
455. The strength of heterocyclic bases (1948)

The first page of this article is displayed as the abstract.
Price Differentials Vary (1948)

In an earlier we looked at daily, monthly and annual price differentials between Chicago and three Iowa markets. Here is the second part: How much do differentials in price between weight groups of slaughter hogs vary at the same market?
Changes in gene expression in response to polyamine depletion indicates selective stabilization of mRNAs (2000)

We used differential display analysis to identify mRNAs responsive to changes in polyamine synthesis. As an overproducing model we used the kidneys of transgenic hybrid mice overexpressing ornithine decarboxylase and S-adenosylmethionine decarboxylase, two key enzymes in polyamine biosynthesis. To identify mRNAs that respond to polyamine starvation, we treated Rat-2 cells with alpha-difluoromethylornithine, a specific inhibitor of polyamine biosynthesis. We isolated 41 partial cDNA clones, representing 37 differentially expressed mRNAs. Of these, 15 have similarity with known genes, five appear to be similar to reported expressed sequence tags and seventeen clones were novel sequences. Of the 35 mRNAs expressed differentially after alpha-difluoromethylornithine treatment, 26 were up-regulated. The expression of only three mRNAs was altered in the transgenic animals and all three were down-regulated. Determination of mRNA half-life of three of the mRNAs up-regulated in response to polyamine depletion revealed that the accumulation results from stabilization of the messages. Because most of the transcripts identified from Rat-2 cells suffering polyamine starvation were accumulated, we conclude that polyamine depletion, while blocking cell growth, is stabilizing mRNAs. This may be due to the lack of spermidine for post-translational modification of the eukaryotic initiation factor 5A, which plays a major role in mRNA turnover. The coupling of mRNA stabilization with cell-growth arrest in response to polyamine starvation provides cells with an economical way to resume growth after recovery from polyamine deficiency.
Coulomb blockade thermometer: Tests and instrumentation (1998)

Coulomb blockade thermometry (CBT) provides a simple method for absolute thermometry in every day laboratory use at cryogenic temperatures. CBT has been found insensitive to even high magnetic fields. We review the principles and the operation of CBT and the fabrication of the sensors, and present new data on radiation hardness and stability of the sensors. We describe the instrumentation of CBT in detail. We have developed two signal conditioning units for CBT measurements. One is a modified alternating current resistance bridge, a versatile laboratory instrument operating with a PC computer, and the other one is a simple stand-alone instrument for direct temperature reading. Test results on their performance are also presented. Both prototypes have a short-term reproducibility of 0.3% or better in temperature measurement.
Effect of Surfactant/Silica Molar Ratios on the Formation of Mesoporous Molecular Sieves: Inorganic Mimicry of Surfactant Liquid-Crystal Phases and Mechanistic Implications (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of Surfactant/Silica Molar Ratios on the Formation of Mesoporous Molecular Sieves: Inorganic Mimicry of Surfactant Liquid-Crystal Phases and Mechanistic ImplicationsJ. C. Vartuli, K. D. Schmitt, C. T. Kresge, W. J. Roth, M. E. Leonowicz, S. B. McCullen, S. D. Hellring, J. S. Beck, J. L. Schlenker, and Cite this: Chem. Mater. 1994, 6, 12, 2317–2326Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/cm00048a018https://doi.org/10.1021/cm00048a018research-articleACS PublicationsRequest reuse permissionsArticle Views3282Altmetric-Citations469LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts