gebhart/patrepeval huggingface dataset:
First-principles studies of complex hydride YMn2H6 and its synthesis from metal hydride YMn2H4.5 (2011)

First-principles calculations were performed for a complex hydride YMn2H6 to investigate its electronic structure and thermodynamic stability. The results indicated that an Y atom and one of two Mn atoms were ionized as Y3+ and Mn2+, respectively, and another Mn atom bound covalently to H atoms to form a [MnH6]5− complex anion. Based on the enthalpy change of −65 kJ/mol estimated from the calculation, we experimentally verified a possible low-pressure synthesis of YMn2H6 from a metal hydride YMn2H4.5. X-ray diffractometry confirmed the formation of YMn2H6 after hydrogenation below 5 MPa, much lower than the previously reported value of 170 MPa.
Circulating antibodies to mouse monoclonal immunoglobulins in normal subjects--incidence, species specificity, and effects on a two-site assay for creatine kinase-MB isoenzyme. (1986)

With a two-site CK-MB assay, we screened serum samples from 1008 blood donors for the presence of antibodies to mouse monoclonal immunoglobulin. These antibodies were capable of cross-linking the labeled antibody with the solid-phase antibody in the two-site assay, thus generating a falsely high apparent CK-MB concentration. In 92 (9.12%) of the blood donors tested, apparent CK-MB concentrations of 10-1000 micrograms/L decreased to less than 3 micrograms/L when re-assayed with non-immune mouse serum (10 mL/L) included in the assay reagent. We tested the ability of non-immune sera from other animal species to lower the concentration of apparent CK-MB in 58 of the 92 samples. Bovine and ovine serum were almost as effective as mouse serum; feline, canine, and rabbit serum were less effective. Of the samples tested, 12% (1.1% of the original population screened) showed apparent CK-MB values that either were not depressed by bovine serum or were only partly depressed. We discuss the possible etiology of these antibodies in normal subjects and recommend that all mouse monoclonal two-site assays should contain non-immune mouse serum (or a suitable "irrelevant" mouse monoclonal antibody) to prevent false-positive results.
Store depletion and store‐operated Ca<sup>2+</sup> current in human prostate cancer LNCaP cells: involvement in apoptosis (2000)

1. In the present study, we investigated the mechanisms involved in the induction of apoptosis by the Ca2+-ATPase inhibitor thapsigargin (TG), in androgen-sensitive human prostate cancer LNCaP cells. 2. Exposure of fura-2-loaded LNCaP cells to TG in the presence of extracellular calcium produced an increase in intracellular Ca2+, the first phase of which was associated with depletion of intracellular stores and the second one with consecutive extracellular Ca2+ entry through plasma membrane, store-operated Ca2+ channels (SOCs). 3. For the first time we have identified and characterized the SOC-mediated membrane current (Istore) in prostate cells using whole-cell, cell-attached, and perforated patch-clamp techniques, combined with fura-2 microspectrofluorimetric and Ca2+-imaging measurements. 4. Istore in LNCaP cells lacked voltage-dependent gating and displayed an inwardly rectifying current-voltage relationship. The unitary conductance of SOCs with 80 mM Ca2+ as a charge carrier was estimated at 3.2 +/- 0.4 pS. The channel has a high selectivity for Ca2+ over monovalent cations and is inhibited by Ni2+ (0.5-3 mM) and La3+ (1 microM). 5. Treatment of LNCaP cells with TG (0.1 microM) induced apoptosis as judged from morphological changes. Decreasing extracellular free Ca2+ to 200 nM or adding 0.5 mM Ni2+ enhanced TG-induced apoptosis. 6. The ability of TG to induce apoptosis was not reduced by loading the cells with intracellular Ca2+ chelator (BAPTA-AM). 7. These results indicate that in androgen-sensitive prostate cancer cells the depletion of intracellular Ca2+ stores may trigger apoptosis but that there is no requirement for the activation of store-activated Ca2+ current and sustained Ca2+ entry in induction and development of programmed cell death.
Mechanical Joining of Fibre Reinforced Polymer Composites to Metals—A Review. Part I: Bolted Joining (2020)

As the fibre reinforced plastic composites gain larger and larger share in industry, the problem of joining them with metal elements becomes significant. The current paper is the first part of the literature review, which gathers and evaluates knowledge about methods suitable for mechanical joining of composite and metal elements. This paper concerns bolted joining, because this method of mechanical joining is widely used for joining composite materials. The paper describes failure modes of bolted joints in composite materials, the influence of the bolt clamping torque, the clearance between the bolt and the hole and aging on the performance of the joint, drilling techniques used in composite materials in order to minimize damages, different fastener types, inspection techniques, and finally, the techniques that have been developed in order to improve the strength of the bolted joints in composites. Since the hole drilled in a composite material in order to perform bolted joining is a weak point of the structure, those techniques: bonded inserts, titanium foil internal inserts, fibre steering, additional reinforcement, and moulded holes, mainly aim to improve the strength of the hole in the composite. The techniques have been discussed in details and compared with each other in the summary section.
Locally optimal codebook design for quadtree-based vector quantization (2002)

The optimal design of quadtree-based vector quantizers is addressed. Until now, work in this area has focused on optimizing the quadtree structure for a given set of leaf quantizers with little attention spent on the design of the quantizers themselves. In cases where the leaf quantizers were considered, codebooks were optimized without regard to the ultimate quadtree segmentation. However, it is not sufficient to consider each problem independently, as separate optimization leads to an overall suboptimal solution. Rather, joint design of the quadtree structure and the leaf codebooks must be considered for overall optimality. The method we suggest is a "quadtree" constrained version of the entropy-constrained vector quantization design method. To this end, a centroid condition for the leaf codebooks is derived that represents a necessary optimality condition for variable-rate quadtree coding. This condition, when iterated with the optimal quadtree segmentation strategy of Sullivan and Baker (see IEEE Trans. on Image Processing, vol.3, p.327-331, May 1994) results in a monotonically descending rate-distortion cost function, and consequently, an (at least locally) optimal quadtree solution.
Hybrid integrated photonics using bulk acoustic resonators (2020)

Integrated photonic devices based on Si<sub>3</sub>N<sub>4</sub> waveguides allow for the exploitation of nonlinear frequency conversion, exhibit low propagation loss, and have led to advances in compact atomic clocks, ultrafast ranging, and spectroscopy. Yet, the lack of Pockels effect presents a major challenge to achieve high-speed modulation of Si<sub>3</sub>N<sub>4</sub>. Here, microwave-frequency acousto-optic modulation is realized by exciting high-overtone bulk acoustic wave resonances (HBAR) in the photonic stack. Although HBAR is ubiquitously used in modern communication and superconducting circuits, this is the first time it has been incorporated on a photonic integrated chip. The tight vertical acoustic confinement releases the lateral design of freedom, and enables negligible cross-talk and preserving low optical loss. This hybrid HBAR nanophotonic platform can find immediate applications in topological photonics with synthetic dimensions, compact opto-electronic oscillators, and microwave-to-optical converters. As an application, a Si<sub>3</sub>N<sub>4</sub>-based optical isolator is demonstrated by spatiotemporal modulation, with over 17 dB isolation achieved.
Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II (2014)

Recent developments in whole genome sequencing have made a substantial contribution to understanding the genomes, neurotoxins and biology of Clostridium botulinum Group I (proteolytic C. botulinum) and C. botulinum Group II (non-proteolytic C. botulinum). Two different approaches are used to study genomics in these bacteria; comparative whole genome microarrays and direct comparison of complete genome DNA sequences. The properties of the different types of neurotoxin formed, and different neurotoxin gene clusters found in C. botulinum Groups I and II are explored. Specific examples of botulinum neurotoxin genes are chosen for an in-depth discussion of neurotoxin gene evolution. The most recent cases of foodborne botulism are summarised.
A 6.5-mW receiver front-end for Bluetooth in 0.18-μm CMOS (2003)

This paper describes the design of a low-IF receiver front-end for Bluetooth fabricated in a 0.18 /spl mu/m CMOS technology. The chip includes an LNA and an image-reject mixer and provides a down-conversion gain to the 2 MHz IF of 21.4 dB, an image rejection of 28 dB and a NF of 13.9 dB consuming only 6.5 mW at 1.8 V.
An efficient lock protocol for home-based lazy release consistency (2002)

Home-based lazy release consistency (HLRC) shows poor performance on lock based applications because of two reasons: a whole page is fetched on a page fault while actual modification is much smaller; and a home is at the fixed location while the access pattern is migratory. We present an efficient lock protocol for HLRC. In this protocol, the pages that are expected to be used by the acquirer are selectively updated using diffs. The diff accumulation problem is minimized by limiting the size of diffs to be sent for each page. Our protocol reduces the number of page faults inside critical sections because pages can be updated by applying locally stored diffs. This reduction yields the reduction of average lock waiting time and the reduction of message amount. The experiment with five applications shows that our protocol archives 2%-40% speedup against base HLRC for four applications.
Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover (2010)

Abstract A number of dopamine‐related genes have been implicated in the etiology of violent behavior and conduct problems. Of these genes, the ones that code for the enzymes that influence the turnover of dopamine (DA) have received the most attention. In this study, we investigated 12 genetic polymorphisms in four genes involved with DA functioning ( COMT , MAOA and MAOB , and DβH ) in 179 incarcerated male Russian adolescents and two groups of matched controls: boys without criminal records referred to by their teachers as (a) “troubled‐behavior‐free” boys, n =182; and (b) “troubled‐behavior” boys, n =60. The participants were classified as (1) being incarcerated or not, (2) having the DSM‐IV diagnosis of conduct disorder (CD) or not, and (3) having committed violent or nonviolent crimes (for the incarcerated individuals only). The findings indicate that, although no single genetic variant in any of the four genes differentiated individuals in the investigated groups, various linear combinations (i.e., haplotypes) and nonlinear combinations (i.e., interactions between variants within and across genes) of genetic variants resulted in informative and robust classifications for two of the three groupings. These combinations of genetic variants differentiated individuals in incarceration vs. nonincarcerated and CD vs. no‐CD groups; no informative combinations were established consistently for the grouping by crime within the incarcerated individuals. This study underscores the importance of considering multiple rather than single markers within candidate genes and their additive and interactive combinations, both with themselves and with nongenetic indicators, while attempting to understand the genetic background of such complex behaviors as serious conduct problems. Aggr. Behav. 36:158–176, 2010. © 2010 Wiley‐Liss, Inc.
Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome (2017)

Glioblastoma is a highly aggressive brain tumor. Current standard-of-care results in a marginal therapeutic outcome, partly due to acquirement of resistance and insufficient blood-brain barrier (BBB) penetration of chemotherapeutics. To circumvent these limitations, we conjugated the chemotherapy paclitaxel (PTX) to a dendritic polyglycerol sulfate (dPGS) nanocarrier. dPGS is able to cross the BBB, bind to P/L-selectins and accumulate selectively in intracranial tumors. We show that dPGS has dual targeting properties, as we found that P-selectin is not only expressed on tumor endothelium but also on glioblastoma cells. We delivered dPGS-PTX in combination with a peptidomimetic of the anti-angiogenic protein thrombospondin-1 (TSP-1 PM). This combination resulted in a remarkable synergistic anticancer effect on intracranial human and murine glioblastoma via induction of Fas and Fas-L, with no side effects compared to free PTX or temozolomide. This study shows that our unique therapeutic approach offers a viable alternative for the treatment of glioblastoma.
IoT Security Framework for Smart Cyber Infrastructures (2016)

The Internet of Things (IoT) will connect not only computers and mobile devices, but it will also interconnect smart buildings, homes, and cities, as well as electrical grids, gas, and water networks, automobiles, airplanes, etc. IoT will lead to the development of a wide range of advanced information services that need to be processed in real-time and require data centers with large storage and computing power. The integration of IoT with Cloud and Fog Computing can bring not only the required computational power and storage capacity, but they enable IoT services to be pervasive, cost-effective, and can be accessed from anywhere using any device (mobile or stationary). However, IoT infrastructures and services will introduce grand security challenges due to the significant increase in the attack surface, complexity, heterogeneity and number of resources. In this paper, we present an IoT security framework for smart infrastructures such as Smart Homes (SH) and smart buildings (SB). We also present a general threat model that can be used to develop a security protection methodology for IoT services against cyber-attacks (known or unknown). Additionally, we show that Anomaly Behavior Analysis (ABA) Intrusion Detection System (ABA-IDS) can detect and classify a wide range of attacks against IoT sensors.
De-convoluting the Genetic Adaptations of E. coli C41(DE3) in Real Time Reveals How Alleviating Protein Production Stress Improves Yields (2015)

The well-established E. coli protein production strain C41(DE3) was isolated from the T7 RNA polymerase-based BL21(DE3) strain for its ability to produce difficult recombinant proteins, and it acquired multiple mutations during its isolation. Standard allelic replacement and competition experiments were insufficient to de-convolute these mutations. By reconstructing the evolution of C41(DE3) in real time, we identified the time frames when the different mutations occurred, enabling us to link them to particular stress events. Starvation stress imposed by the isolation procedure selected for mutations enhancing nutrient uptake, and protein production stress for mutations weakening the lacUV5 promoter, which governs t7rnap expression. Moreover, recapitulating protein production stress in BL21(DE3) showed that mutations weakening the lacUV5 promoter occur through RecA-dependent recombination with the wild-type lac-promoter and are selected for upon the production of any protein. Thus, the instability of the lacUV5 promoter in BL21(DE3) alleviates protein production stress and can be harnessed to enhance production.
Diverse effects of Glut 4 ablation on glucose uptake and glycogen synthesis in red and white skeletal muscle. (1996)

The ability of muscles from Glut 4-null mice to take up and metabolize glucose has been studied in the isolated white EDL and red soleus muscles. In EDL muscles from male or female Glut 4-null mice, basal deoxyglucose uptake was lower than in control muscles and was not stimulated by insulin. In parallel, glycogen synthesis and content were decreased. Soleus muscles from male Glut 4-null mice took up twice more deoxyglucose in the absence of insulin than control muscles, but did not respond to insulin. In females, soleus deoxyglucose uptake measured in the absence of hormone was similar in Glut 4-null mice and in control mice. This uptake was stimulated twofold in Glut 4-null mice and threefold in control mice. Basal glycogen synthesis was increased by 4- and 2.2-fold in male and female null mice, respectively, compared to controls, and insulin had no or small (20% stimulation over basal) effect. These results indicate that while EDL muscles behaved as expected, soleus muscles were able to take up a large amount of glucose in the absence (males) or the presence of insulin (females). Whether this is due to a change in Glut 1 intrinsic activity or targeting and/or to the appearance of another glucose transporter remains to be determined.
Hybrid integrated lumped-element microwave amplifiers (1968)

This paper describes the development of microwave lumped-element thin-film amplifiers. The basic design philosophy underlying lumped inductors and capacitors at microwave frequencies is reviewed, showing how Q's of 100 are achieved. A variety of tunable input, output, and interstage integrated lumped-element networks for transistor amplifiers were fabricated. The gain and efficiency of 2-GHz class-C operated transistors mounted in these circuits were comparable with the best performance achieved by the same transistors in less lossy coaxial circuits. The measured losses (1.2 dB) at 2 GHz were very close to those calculated using the design parameters. Single-stage amplifiers at 2 GHz achieved one watt of output power with 4 dB of gain. At somewhat lower power levels more than 6 dB of gain was achieved. The circuits allowed the operation of low-power level class-A amplifiers with over 13 dB of gain. Cascaded operation yielded more than 17 dB of gain with 0.8 watts of CW power. It is concluded that lumped elements can be fabricated by thin-film technology and will play an important role in microwave integrated circuits.
Murine monoclonal anti-idiotypic antibody as a surrogate antigen for human Her-2/neu (2001)

The anti-idiotypic (Id) monoclonal antibody (MAb) 520C9-6b (IgG1k), raised in syngenic mice against the murine anti-Her2/neu MAb 520C9 (Ab1), functionally mimics a human Her2/neu epitope and serves as a surrogate for the protein antigen. Immunization of allogeneic C57BL/6 mice and rabbits with 520C9-6b (Ab2) induced anti-Her2/neu-specific antibodies that react with antigen-positive SKBr3 cells by ELISA and FACS analysis. The immune sera inhibited binding between Ab1 and Ab2 and vice versa (binding of Ab2 to Ab1), indicating that it was a true anti-anti-Id (Ab3) antibody. The Ab3 sera or purified Ab3 specifically lysed Her2/neu-positive SKBr3 cells, but no significant lysis was observed in antigen-negative LS174T cells in an antibody-dependent cellular cytotoxicity assay. An Id-specific cellular immune response was also demonstrated in an in vitro lymphocyte proliferation assay. Furthermore, a panel of tumor tissues and tumor cells was screened for the presence of the Her2/neu epitope by its reactivity with Ab1 and Ab3 using immunohistochemistry and FACS analysis. Identical results were obtained using either Ab1 or Ab3 (Ab1'). The data indicated that anti-Id 520C9-6b can induce Her2/neu-specific antibody in experimental animals and may serve as a potential network antigen for the treatment of patients bearing Her2/neu-positive tumors.
Efficient and Secure Resource Management in Home M2M Networks (2013)

In recent years, M2M networking is an active research topic in both academic and industrial fields. Home M2M networks, as an important branch of M2M networks, have attracted wide concerns for home application. In this paper, we first present a brief overview of home M2M networks. Then we introduce a hierarchical architecture of home M2M networks and describe the approach of devices management and services discovery. After that, we focus on the security authentication with centralized node and an improved method of available bandwidth measurement. With the centralized node, our system is more efficient and secure, because of efficient resource management and users' anonymity protection. Compared to existing bandwidth measurement methods, our method takes up less additional bandwidth, saves more time, and has a higher accuracy for measurement. Experiments are carried out to demonstrate the effectiveness and accuracy of the proposed scheme.
A Statistical Approach of Keyword Extraction for Efficient Retrieval (2017)

Large number of techniques for keyword extraction have been proposed for better matching of documents with the user's query but most of them deal with tf-idf to find the weight age of query terms in the entire document but this can result in improper result as if a term has a low term frequency in overall document but high frequency in a certain part of the document then that term can be ignored by traditional tf-idf method. Through this paper, the keyword extraction is improved using a hybrid technique in which the entire document is split into multiple domains using a master keyword and the frequency of all unique words is found in every domain . The words having high frequency are selected as candidate keywords and the final selection is made on the basis of a graph which is constructed between the keywords using Word Net. The experiments, conducted on various documents show that proposed approach outperforms other keyword extraction methodologies by enhancing document retrieval.
Modifying smartphone user locking behavior (2013)

With an increasing number of organizations allowing personal smart phones onto their networks, considerable security risk is introduced. The security risk is exacerbated by the tremendous heterogeneity of the personal mobile devices and their respective installed pool of applications. Furthermore, by virtue of the devices not being owned by the organization, the ability to authoritatively enforce organizational security polices is challenging. As a result, a critical part of organizational security is the ability to drive user security behavior through either on-device mechanisms or security awareness programs. In this paper, we establish a baseline for user security behavior from a population of over one hundred fifty smart phone users. We then systematically evaluate the ability to drive behavioral change via messaging centered on morality, deterrence, and incentives. Our findings suggest that appeals to morality are most effective over time, whereas deterrence produces the most immediate reaction. Additionally, our findings show that while a significant portion of users are securing their devices without prior intervention, it is difficult to influence change in those who do not.