gebhart/patrepeval huggingface dataset:
Hypotensive compounds isolated from alcohol extract of the unossified horn of Cervus elaphus L. var. xanthopygus MILNE-EDWARG (Rokujo). I. Isolation of lysophosphatidyl choline as a hypotensive principle and structure-activity study of related compounds. (1987)

By the use of spontaneously hypertensive rats (SH rats) as a screening system, two hypotensive compounds were isolated from alcohol extract of the unossified horn of Cervus elaphus L. var. xanthopygus (Rokujo). One of the two compounds was identified as lysophosphatidyl choline (LPC). It was shown by gas chromatography that palmitic acid (C16 : 0) accounted for about half of the fatty acid content. Next, the effects of various LPCs on SH rats were examined. Eleven LPCs with C10 : 0 to C20 : 0 fatty acids were examined, and all except for those with C10 : 0 and C20 : 0 fatty acids showed the hypotensive effect (3 mg/kg, i.v.). In particular, C14 : 0 and C16 : 0-LPC showed rather potent activity. On the other hand, of the six LPCs with unsaturated fatty acids, only C16 : 1-LPC showed the hypotensive effect (3 mg/kg). It was concluded that at least a part of the hypotensive action of alcohol extract of Rokujo is due to LPC.
Interleukin‐1 receptor antagonist in patients with active systemic lupus erythematosus: enhanced production by monocytes and correlation with disease activity (1995)

A high serum concentration of IL-1Ra is a pathophysiologic feature of active SLE and a good indicator of disease activity. Functional changes of monocytes, such as increased secretion of IL-1Ra in response to adherent IgG and enhanced expression of IL-1Ra mRNA in freshly isolated cells, may be involved in the enhanced IL-1Ra production in active SLE. High concentrations of IL-1Ra in the circulation and possibly in peripheral lymphoid tissues may influence immunologic and inflammatory features of SLE.
Focused Ultrasound to Expel Calculi From the Kidney (2011)

Transcutaneous ultrasonic propulsion was used to expel calculi effectively and safely from the kidney using a live animal model. This study is the first step toward an office based system to clear residual fragments and toward use as a primary treatment modality in conjunction with medical expulsive therapy for small renal stones.
KNOWLEDGE SUPERVISED PERCEPTUAL GROUPING BASED QUALITATIVE BUILDING DETECTION FROM MONOCULAR AERIAL IMAGES (2003)

This paper addresses an important and practical problem in computer vision and pattern recognition — qualitative target detection from aerial images. In particular, it discusses the problem of qualitative building detection based on a monocular aerial image. The approach proposed, due to its independence of site models or camera calibration information, complements the model based approaches developed in the rest of the research community of building detection from aerial images. Specifically, a knowledge supervised perceptual grouping (KSPG) system based on reinvestigation, and hypothesis generation and verification, is presented, and is shown to be reasonably robust in experiments using real data.
Measurement of density in a discharge by intracavity laser absorption spectroscopy and CW cavity ring-down spectroscopy (1998)

Two highly sensitive and quantitative absorption techniques have been applied to the detection of in an argon-5% silane DC discharge, the new method of CW cavity ring-down spectroscopy (CWCRDS) and intracavity laser absorption spectroscopy (ICLAS). Doppler-limited absorption lines of the transition around 580 nm could be observed. By using the rotational constants and the electronic transition moment available in the literature, we have calculated the line intensity of some specific rovibronic transitions from which we deduced the concentration of in the discharge to be about . Taking into account the signal-to-noise ratio, concentrations as small as a few times can be detected by both methods. We also observed a weak broadband absorption of several due to the dust particles formed in the plasma volume, which for particles of 1 nm diameter would correspond to a few times . The performances of ICLAS and CWCRDS are compared.
A Fast Parametric Maximum Flow Algorithm and Applications (1989)

The classical maximum flow problem sometimes occurs in settings in which the arc capacities are not fixed but are functions of a single parameter, and the goal is to find the value of the parameter such that the corresponding maximum flow or minimum cut satisfies some side condition. Finding the desired parameter value requires solving a sequence of related maximum flow problems. In this paper it is shown that the recent maximum flow algorithm of Goldberg and Tarjan can be extended to solve an important class of such parametric maximum flow problems, at the cost of only a constant factor in its worst-case time bound. Faster algorithms for a variety of combinatorial optimization problems follow from the result.
Aberration-Correcting Properties of the Hyperbolic Electron Mirror (1985)

Spherical and chromatic aberration are inherent in electron lenses. Under certain conditions the possibility exists that these lens aberrations can be eliminated or compensated. The conditions under which such corrections are possible (in principle) have been characterized originally by Scherzer and later by Septier. One type of correcting system involves the use of an electrostatic electron mirror. The work presented here deals with the properties of hyperbolic electron mirrors and the conditions for matching the correcting properties of a mirror to the spherical and chromatic aberration of a lens or lens system. In an earlier work by the authors, the properties of the hyperbolic mirror were studied for rays incident on the mirror parallel to the optical axis. In the present work, symmetrical rays are studied.
Lactate and pyruvate electrochemical biosensors for whole blood in extracorporeal experiments with an endocrine artificial pancreas. (1987)

Glucose, lactate, and pyruvate can be continuously measured in whole blood by using three extracorporeal electrochemical biosensors. We fixed two newly developed sensors, for lactate and pyruvate, in series with an endocrine artificial pancreas ("Betalike") without affecting its performance. These new sensors for use with whole blood should be able to clarify the fate of the intermediary metabolites of glucose in diabetic patients receiving infusions of drugs or insulin.
Thymosin <i>β</i><sub>10</sub> mRNA expression during early postimplantation mouse development (1996)

The beta-thymosins are a family of monomeric actin sequestering peptides that regulate actin dynamics within the cells. During embryogenesis the control of actin polymerization is essential in processes such as cell migration, angiogenesis and neurogenesis. Here we report that the levels of thymosin beta10 (Tbeta10) mRNA strongly increase during early postimplantation mouse embryogenesis as well as during in vitro P19 cell differentiation, indicating that this peptide plays an important role in early development. Moreover, analysis of the spatial distribution of Tbeta10 mRNA in 9.5-12.5 days postcoitum mouse embryos showed a remarkable presence of this transcript in mesenchymal structures as well as in the mantle layer of spinal cord. Interestingly, we observed differences in the distribution of the mRNAs encoding Tbeta10 and Tbeta4, another member of the beta-thymosin family, suggesting different roles for these peptides during mouse embryogenesis.
ScatterScanner: Data Extraction and Chart Restyling of Scatterplots (2013)

Commonly, publications do not expose their underlying data, only simple (often poorly designed) visualizations thereof. Many authors want to source data from other papers, yet if they include the pre-designed visualization they are chained to the design choices of the original author. This is a pain point for authors who want holistic control over the design language of their publication. In order to solve this problem, we present ScatterScanner, a web interface that will process an image, extract the data, and allow the user to modify design choices such as chart form, color, spatial relationships etc. In addition, we provide an option to download the extracted data from the visualization in the form of a .csv file so that the user can save and modify this data in other applications. Due to the
A minimal system allowing tubulation with molecular motors pulling on giant liposomes (2002)

The elucidation of physical and molecular mechanisms by which a membrane tube is generated from a membrane reservoir is central to the understanding of the structure and dynamics of intracellular organelles and of transport intermediates in eukaryotic cells. Compelling evidence exists that molecular motors of the dynein and kinesin families are involved in the tubulation of organelles. Here, we show that lipid giant unilamellar vesicles (GUVs), to which kinesin molecules have been attached by means of small polystyrene beads, give rise to membrane tubes and to complex tubular networks when incubated in vitro with microtubules and ATP. Similar tubes and networks are obtained with GUVs made of purified Golgi lipids, as well as with Golgi membranes. No tube formation was observed when kinesins were directly bound to the GUV membrane, suggesting that it is critical to distribute the load on both lipids and motors by means of beads. A kinetic analysis shows that network growth occurs in two phases: a phase in which membrane-bound beads move at the same velocity than free beads, followed by a phase in which the tube growth rate decreases and strongly fluctuates. Our work demonstrates that the action of motors bound to a lipid bilayer is sufficient to generate membrane tubes and opens the way to well controlled experiments aimed at the understanding of basic mechanisms in intracellular transport.
CDA: concealed data aggregation for reverse multicast traffic in wireless sensor networks (2005)

End-to-end encryption for wireless sensor networks is a challenging problem. To save the overall energy resources of the network, it is agreed that sensed data need to be consolidated and aggregated on their way to the final destination. We present an approach that (1) conceals sensed data end-to-end, by (2) still providing efficient in-network data aggregation. The aggregating intermediate nodes are not required to operate on the sensed plaintext data. We apply a particular class of encryption transformation and exemplarily discuss the approach on the basis of two aggregation functions. We use actual implementation to show that the approach is feasible and flexible and frequently even more energy efficient than hop-by-hop encryption.
Practical Synthesis of Iodo Phenothiazines. A Facile Access to Electrophore Building Blocks (2003)

Bromine-lithium exchange of the mono- and dibromophenothiazines 1 and 3a regiospecifically furnishes upon electrophilic trapping with iodine the iodo- and diiodophenothiazines 2, 3b, and 3d in excellent yield. The 3-bromo-7-iodophenothiazine 3d can be submitted to regioselective and sequential Suzuki coupling reactions with phenothiazine mono- and bisboronates 4 and 5 and/or (hetero)aryl boronic acids to give the bromodiphenothiazine 6a, the dibromo terphenothiazine 7, and the (hetero)aryl-substituted phenothiazine dyads 6b-d in moderate to good yields.
Synthesis of 2,3-Substituted Thienylboronic Acids and Esters (2003)

A noncryogenic protocol for the synthesis of 2-substituted 3-thienylboronic acids and esters as well as 3-substituted 2-thienylboronic acids and esters has been developed. Electrophiles were introduced regiospecifically in the 2-position of 2,3-dibromothiophene and in the 3-position of 2-bromo-3-iodothiophene by halogen-magnesium exchange followed by quenching with electrophiles. Palladium-catalyzed borylation of the 2,3-substituted halothiophenes with pinacolborane and P(t-Bu)3 as ligand for Pd produced 9 and 10. The borylation protocol was tolerated by a range of functional groups; however, strongly electron-withdrawing substituents decreased the stability of the thienylboronic acids and esters.
In situ analysis of tumor-specific CTL effector and memory responses elicited by tumor vaccination. (1999)

In this study tumor-specific CTL effector and memory responses were analyzed in normal mice, in tumor bearing mice and in animals treated by active specific immunotherapy (ASI) with an autologous virus modified tumor vaccine. In the well defined DBA/2 mouse lymphoma model ESb, the tumor specific CTL response requires interactions of four different cell types and recognition of MHC class I and class II restricted tumor antigens either on host antigen presenting cells (APCs) or on the tumor cells. The most effective in situ activation of syngeneic tumor specific CTL can be generated within no more than 9 days by primary immunization in the ear pinna and restimulation in the peritoneal cavity. Here we describe modulatory effects of either cytokines or of virus infection of tumor stimulator cells during restimulation in the peritoneal cavity on the CTL memory response. The in situ peritoneal effector cell (PEC) response was augmented when Newcastle Disease Virus (NDV) was used to infect tumor cells which expressed the correct tumor associated antigen of the memory response but not when a third party tumor cell was infected and admixed. A response could also be augmented by co-administration of interferons-alpha, -beta or IL-2 and by pre-treatment with low dose cyclophosphamide. Therapeutic vaccination effects could be achieved in mice inoculated s.c. with this aggressive and metastatic tumor variant if the vaccine was given very early, i.e. 1-2 days after priming and when the vaccine was applied post-operatively, i.e. in situations of low tumor burden. A long-term CTL memory response could be demonstrated even two months after post-operative active specific immunotherapy with ESb-NDV vaccine.
Collagen Biomechanics in Cerebral Arteries and Bifurcations Assessed by Polarizing Microscopy (2003)

Collagen is the main matrix protein of the artery wall. We have used the known correlation between collagen birefringence and its mechanical properties to assess the wall structural integrity in brain arteries and their bifurcation regions, which are the sites of formation of saccular aneurysms. Segments of 28 brain arteries, including bifurcations, were pressure fixed and sectioned in one of three orthogonal planes. Measurements were taken by polarizing microscopy of the birefringence of collagen fibers at the apex of bifurcations and in the main layers of the artery wall - adventitia, media and intima. Dimensional data were obtained of the layers in order to estimate wall properties. Along the apex of the flow divider we measured a narrow band of collagen (birefringence 30% higher than the adjacent adventitia) providing strength and stiffness in that region. There is a thin cell-free outer layer of the tunica media (mean thickness 11 microm) comprised of densely packed coaligned collagen with high birefringence. From the fiber birefringence and directional alignment of the individual layers we calculated that the adventitia contributes about one third of circumferential and almost all of longitudinal strength of intracranial arteries.
Naphthodifuran alternating quinoxaline copolymers with a bandgap of ∼1.2 eV and their photovoltaic characterization (2014)

Four new alternating copolymers of naphthodifuran and quinoxaline have been developed. With the bandgap as low as 1.2 eV, polymers exhibited extended absorption to 1200 nm. Their potential in bulk heterojunction solar cells was evaluated. With device optimization, triazoloquinoxaline based polymers contributed the highest power conversion efficiency of 0.84%.
Partitioning of Polymeric Plutonium(IV) in Winsor II Microemulsion Systems (1992)

Abstract The hydrolysis and polymerization of Pu(IV) can cause serious problems during the aqueous processing of spent fuel and nuclear wastes. Several studies describing the liquid/liquid extraction behavior of polymeric Pu(IV) have been reported in the literature. In many cases, poor plutonium extraction was accompanied by the appearance of an interfacial crud or third phase. Invariably, poor mass balances were observed during the extraction of aged, colloidal Pu(IV). Extraction of colloidal Pu(IV) by microemulsion-based solvent extraction systems, however, is capable of attaining bulk phase mass balances for Pu of 100%. The Winsor II microemulsions discussed in this paper consisted of sodium bis(2-ethylhexyl) sulfosuccinate in hexane with either octylphenyl-N,N-diisobutylcarbamoylmethyl-phosphine oxide or tributyl phosphate as coextractant. Backextraction of plutonium from microemulsion phases was achieved by Pu encapsulation in silica particles that were produced by the acid-catalyzed hydrolysis and polymerization of tetraethoxysilane within the aqueous microdroplets of the microemulsion.
Performance Improvement of Model-Predictive Current Control of Permanent Magnet Synchronous Motor Drives (2017)

Model-predictive current control (MPCC) is widely recognized as a high-performance control strategy of permanent magnet synchronous machine (PMSM) drives due to its quick response and simple principle. It uses a cost function to select the best voltage vector minimizing the current error between the reference value and the feedback value. However, as only one voltage vector is applied during one control period, it fails to give satisfactory performance due to the limited voltage vectors, especially in the case of two-level converters. This paper proposes an improved MPCC strategy for PMSM drives, which first estimates the back electromotive force (EMF) based on the past value of stator voltage and currents and then applies the estimated EMF in the stator current prediction. To achieve steady-state performance improvement, a null vector along with the active vector obtained from conventional MPCC is applied during one control period. Two methods are proposed to achieve optimal vector selection and vector duration. The first one requires six predictions and the calculation of current differentiation, while the second one only requires one prediction to obtain the best voltage vector and its optimal duty can be obtained in a very efficient way. The proposed methods are comparatively studied and compared to conventional MPCC and deadbeat control with space vector modulation. Both simulation and experimental results confirm the effectiveness of the proposed methods in achieving good steady-state performance while maintaining quick dynamic response.
Differential cyclin-dependent kinase expression and activation in human colon cancer. (1999)

CDK1 especially, and to a lesser extent CDK2 and CDK6 demonstrate the most consistent biochemical activation in human colon cancer and may represent targets for pharmacological intervention. Cellular proliferation as gauged by MIB1 was not directly correlated with the amplitude of activation.
Objects Tracking from Natural Features in Mobile Augmented Reality (2013)

Real world objects are recognized by tracking less and tracking based techniques. Mobile augmented reality browsers are tracking less systems, which acquires location data using global positioning system and provide information in the form of maps or web links. Tracking based techniques recognize objects through markers or directly real world objects without markers. Marker based systems actually track the markers not the real objects and therefore, these approaches hides the reality. Marker- less (direct real object tracking) systems use client-server architecture. However, these are affected by network latency. The Smartphone is capable to recognize and track real world objects without any server and marker. It can guide the users about their location and also provide information in a convenient way. Therefore, an improved algorithm for tracking real world objects through natural features was formulated. The modified version of speed up robust features (SURF) was used for features extraction from live mobile camera image and recognition. The pose matrix from extracted features was calculated by Homography. The adapted algorithm was tested in a mobile AR-prototype application using iPhone. It was found from the results that the formulated algorithm recognized and tracked the real world objects from natural features in speedy, easy and convenient way
Application and comparison of NSGA-II and MOPSO in multi-objective optimization of water resources systems (2018)

Abstract Optimal operation of reservoir systems is the most important issue in water resources management. It presents a large variety of multi-objective problems that require powerful optimization tools in order to fully characterize the existing trade-offs. Many optimization methods have been applied based on mathematical programming and evolutionary computation (especially heuristic methods) with various degrees of success more recently. This paper presents an implementation and comparison of multi-objective particle swarm optimization (MOPSO) and non-dominated sorting genetic algorithm II (NSGA-II) for the optimal operation of two reservoirs constructed on Ozan River catchment in order to maximize income from power generation and flood control capacity using MATLAB software. The alternative solutions were based on Pareto dominance. The results demonstrated superior capacity of the NSGA-II to optimize the operation of the reservoir system, and it provides better coverage of the true Pareto front than MOPSO.
Intraaortic balloon tamponade during hemorrhagic shock in sheep. (1988)

Two groups (n = 10 in each) of adult sheep were exposed to hemorrhagic shock resulting in mean arterial pressure (MAP) below 25 mmHg for 10 min. Following that, group A received crystalloids (8% of body wt) during one hr together with supraceliac intraaortic balloon tamponade during the first 30 min, while group B (controls) received crystalloids only. The central circulation was rapidly restored in group A, as indicated by increased MAP and increased systemic vascular resistance (SVR). After deflation of the balloon MAP dropped to the same value as in the control group, while cardiac index increased gradually with volume replacement and was significantly higher at the end of the resuscitation period (60 min) than in the control group (P less than 0.05). Despite a more rapid restoration of central hemodynamics in group A, lactic acidosis was more severe, acute renal failure and neurological complications more frequent, and mortality higher than in the control group. It was concluded that continuous supraceliac aortic occlusion for 30 min had deleterious effects on organs dependent on aortic blood flow distal to the aortic tamponade and may contribute to the development of multiple organ failure after resuscitation from hemorrhagic shock. Further studies are needed to evaluate the effects of intermittent intraaortic balloon tamponade in hemorrhagic shock.
A plasma window for vacuum–atmosphere interface and focusing lens of sources for nonvacuum ion material modification (invited) (1998)

Material modifications by ion implantation, dry etching, and microfabrication are widely used technologies, all of which are performed in vacuum, since ion beams at energies used in these applications are completely attenuated by foils or by long differentially pumped sections, which are currently used to interface between vacuum and atmosphere. A novel plasma window, which utilizes a short arc for vacuum–atmosphere interface, has been developed. This window provides for sufficient vacuum atmosphere separation, as well as for ion beam propagation through it, thus facilitating nonvacuum ion material modification.