gebhart/patrepeval huggingface dataset:
Prediction of Methane Production from Dairy and Beef Cattle (2007)

Methane (CH4) is one of the major greenhouse gases being targeted for reduction by the Kyoto protocol. The focus of recent research in animal science has thus been to develop or improve existing CH4 prediction models to evaluate mitigation strategies to reduce overall CH4 emissions. Eighty-three beef and 89 dairy data sets were collected and used to develop statistical models of CH4 production using dietary variables. Dry matter intake (DMI), metabolizable energy intake, neutral detergent fiber, acid detergent fiber, ether extract, lignin, and forage proportion were considered in the development of models to predict CH4 emissions. Extant models relevant to the study were also evaluated. For the beef database, the equation CH4 (MJ/d) = 2.94 (+/- 1.16) + 0.059 (+/- 0.0201) x metabolizable energy intake (MJ/d) + 1.44 (+/- 0.331) x acid detergent fiber (kg/d) - 4.16 (+/- 1.93) x lignin (kg/d) resulted in the lowest root mean square prediction error (RMSPE) value (14.4%), 88% of which was random error. For the dairy database, the equation CH4 (MJ/d) = 8.56 (+/- 2.63) + 0.14 (+/- 0.056) x forage (%) resulted in the lowest RMSPE value (20.6%) and 57% of error from random sources. An equation based on DMI also performed well for the dairy database: CH4 (MJ/d) = 3.23 (+/- 1.12) + 0.81 (+/- 0.086) x DMI (kg/d), with a RMSPE of 25.6% and 91% of error from random sources. When the dairy and beef databases were combined, the equation CH4 (MJ/d) = 3.27 (+/- 0.79) + 0.74 (+/- 0.074) x DMI (kg/d) resulted in the lowest RMSPE value (28.2%) and 83% of error from random sources. Two of the 9 extant equations evaluated predicted CH4 production adequately. However, the new models based on more commonly determined values showed an improvement in predictions over extant equations.
Timing extraction and carrier estimation for PSK signal block demodulation system (1989)

Abstract In recent years, block demodulation systems have been proposed which store blocks of phase‐shift keying (PSK) signal and derive data by batch processing. In such systems the traditional method of realtime demodulation is not considered and block processing is applied after quasicoherent demodulation. Training signals required for traditional methods are not at all needed for this system. Therefore, the data transmission efficiency becomes very high. However, conventional block demodulators have a serious disadvantage–they cannot demodulate the signal without external timing information. This paper proposes a new timing extraction circuit not contained in a conventional block demodulator, which improves greatly practical applicability. Also, a method is proposed for accurate carrier estimation. According to computer simulation results, the permissible noise limit becomes 4 to 5 dB lower in comparison to the conventional method.
Synchronized Robot Drumming by Neural Oscillator. (2001)

Sensory-motor integration is one of the key issues in robotics. In this paper, we propose an approach to rhythmic arm movement control that is synchronized with an external signal based on exploiting a simple neural oscillator network. Trajectory generation by the neural oscillator is a biologically inspired method that can allow us to generate a smooth and continuous trajectory. The parameter tuning of the oscillators is used to generate a synchronized movement with wide intervals. We adopted the method for the drumming task as an example task. By using this method, the robot can realize synchronized drumming with wide drumming intervals in real time. The paper also shows the experimental results of drumming by a humanoid robot.
New Developments in the Treatment of Castration-Resistant Prostate Cancer (2014)

During the past 4 years, a host of new agents have been approved for the treatment of patients with advanced prostate cancer. As a result, selecting the right agent for the right patient at the right time is a clinical challenge. At the NCCN 19th Annual Conference, Dr. Celestia Higano explored the rationale behind such therapeutic decisions and the supporting clinical trial data. She reviewed the different classes of therapeutic agents, from immunotherapy and hormonal therapies to chemotherapy and radioisotopes, and offered suggestions for the clinical scenarios in which they may be used most successfully.
Universal voltage-mode filter with four inputs and one output using two CCII s (1999)

A novel universal voltage-mode second-order filter with four inputs and one output employing only two plus-type second-generation current conveyors (CCII+s), two capacitors and three resistors is presented. The proposed circuit offers the advantageous features: realization of lowpass, bandpass, highpass, notch and allpass signals from the same configuration, orthogonal control of ω0 and Q and low active and passive sensitivities. The use of only CCII+s simplifies the configuration except for class-A operation.
Non‐destructive biomass estimation of tree seedlings using image analysis (1995)

The biomass of Pinus sylvestris, Pinus contorta and Pinus cembra seedlings that were raised in three different growing media, as well as of naturally regenerated P. sylvestris saplings, was estimated using functions based on variables measured non‐destructively. These included stem diameter, seedling height, number of needles and branches, length of the longest needle, and projected seedling or sapling crown area. Projected area of a two‐dimensional video image of the seedling or sapling was measured using computer‐based image analysis. The variables were tested in all possible combinations to achieve the best biomass estimate. Projected area alone explained more than 97% of the variation in seedling or sapling mass. Addition of stem diameter increased the degree of explanation to more than 98%, whereas the other variables did not contribute further. Separate functions for species and growing media resulted in more precise estimates than if general functions were used.
Infection with paramyxoviruses stimulates synthesis of cellular polypeptides that are also stimulated in cells transformed by Rous sarcoma virus or deprived of glucose (1978)

Infection of several types of cultured cells with the paramyxoviruses simian virus 5 and Sendai virus stimulates synthesis of four polypeptides (I-IV) with molecular weights of approximately 99,000, 97,000, 86,000, and 78,000, respectively. That these are host polypeptides encoded in cellular mRNAs has been shown by the inhibition of their synthesis by actinomycin D and by the similarity of the peptide maps of them and of polypeptides with the same electrophoretic mobility from uninfected cells. Peptide mapping as well as identical migration in polyacrylamide gels has also indicated that polypeptides I, II, and IV are the same as plasma membrane polypeptides whose synthesis is enhanced in cells transformed by Rous sarcoma virus and in normal cells by glucose deprivation or treatment with 2-deoxyglucose. Polypeptides I and II appear to be the same polypeptides, with the observed differences in migration reflecting the glycosylation of polypeptide I, a relationship previously shown to exist between polypeptides in glucose-deprived and glucose-fed cells. Infection with paramyxoviruses does not significantly increase the transport of glucose by cells, and the maintenance of a high concentration of glucose in the medium does not prevent the enhanced synthesis of these polypeptides. This is in contrast to the situation in transformed cells in which stimulation of synthesis of these polypeptides is secondary to depletion of glucose in the medium due to increased glucose uptake by the cells. Thus, although paramyxovirus infection and transformation by Rous sarcoma virus result in stimulation of the synthesis of the same membrane polypeptides, the mechanism of stimulation differs.
The Development of Goat Models to Evaluate the Effectiveness of Negative Pressure in Promoting Tissue Ingrowth into Porous Metal Implants (2012)

The repair of large segmental bone defects is problematic with a high risk of infection, large amounts of soft tissue damage, and fracture stabilization difficulties. This preliminary study evaluates three large animal caprine models. These models will be used in future studies to examine the effects of negative pressure to induce bone and soft tissue growth into porous metal implants for the repair of large segmental defects. In Aim #1 bilateral surgery was performed on 6 goats, attaching one large porous titanium implant to the lateral side of each femur. One leg of each animal served as the control while the other side was treated with Negative Pressure Wound Therapy (NPWT) at either -125 mmHg or -200 mmHg. Tissue ingrowth for each negative pressure was examined at 6, 9, and 12 days. After gross examination, 6 of 6 animals showed improved tissue adhesion to the implant treated with NPWT when compared to the implant not treated with NPWT. Two pilot animals were added to the original protocol in order to explore the iliac crest as a better implant location for soft tissue study. The iliac crest was easier to access, maintain cleanliness of the surgical site, and maintain fixation over the greater trochanter and is recommended as the preferred location for future soft tissue studies. In Aim #2 unilateral surgeries were performed on 8 goats, replacing a 35 mm diaphyseal segment on the tibia with a porous titanium cylinder (20 mm diameter) and using orthogonal plates to provide rigid fixation. Four goats received no additional therapy and served as the controls while the other 4 goats received NPWT at -125 mmHg directly on the implant for 24-72 hours. Two goats from each group were sacrificed at 6 weeks and 12 weeks and examined qualitatively and iomechanically. Longer durations of therapy need to be examined to determine the effects of negative pressure therapy on bone growth.
Low Complexity Adaptive Turbo Frequency-Domain Channel Estimation for Single-Carrier Multi-User Detection (2008)

Adaptive turbo frequency-domain channel estimation is incorporated with low complexity turbo space-frequency equalization (TSFE) for single-carrier (SC) multi-user detection. The simplified turbo recursive least square (RLS) channel estimation algorithm provides nearly the same performance as its full complexity version, with a tremendous complexity reduction. With PSK modulations, the simplified turbo RLS channel estimation reduces to turbo LMS channel estimation. With a low training overhead, the simplified turbo RLS channel estimation provides a performance comparable to the case with perfect channel state information (CSI).
A new robust watermarking scheme for color images (2010)

In this paper, a novel watermarking scheme for color images is proposed. The host image is transformed from RGB color space to YCbCr color space. First discrete cosine transform is applied on all the components of the image and then all the transformed components are further decomposed by l-level wavelet packet transform. A gray scale watermark is embedded in all the frequency sub-bands of the image. A reliable extraction scheme is developed for the extraction of the watermark from the distorted images. Experimental results show that the proposed watermarking algorithm provides good results in terms of imperceptibility and is also robust against variety of attacks.
Solution‐Processed Metallic Nanowire Electrodes as Indium Tin Oxide Replacement for Thin‐Film Solar Cells (2011)

Abstract Solution processed silver nanowire (Ag NW) films are introduced as transparent electrodes for thin‐film solar cells. Ag NW electrodes were processed by doctor blade‐coating on glass substrates at moderate temperatures (less than 100 °C). The morphological, optical, and electrical characteristics of these electrodes were investigated as a function of processing parameters. For solar‐cell application, Ag NW electrodes with an average transparency of 90% between 450 and 800 nm and a sheet resistivity of ≈10 Ω per square were chosen. The performance of poly(3‐hexylthiophen‐2,5‐diyl):[6,6]‐phenyl‐C61‐butyric acid methyl ester (P3HT:PCBM) solar cells on Ag NW electrodes was found to match the performance of otherwise identical cells on indium tin oxide. Overall, P3HT:PCBM solar cells with an efficiency of 2.5% on transparent Ag NW electrodes have been realized.
mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON (2011)

The mammalian target of rapamycin (mTOR) signaling exists in two complexes: mTORC1 and mTORC2. Neurotensin (NT), an intestinal hormone secreted by enteroendocrine (N) cells in the small bowel, has important physiological effects in the gastrointestinal tract. The human endocrine cell line BON abundantly expresses the NT gene and synthesizes and secretes NT in a manner analogous to that of N cells. Here, we demonstrate that the inhibition of mTORC1 by rapamycin (mTORC1 inhibitor), torin1 (both mTORC1 and mTORC2 inhibitor) or short hairpin RNA-mediated knockdown of mTOR, regulatory associated protein of mTOR (RAPTOR), and p70 S6 kinase (p70S6K) increased basal NT release via upregulating NT gene expression in BON cells. c-Jun activity was increased by rapamycin or torin1 or p70S6K knockdown. c-Jun overexpression dramatically increased NT promoter activity, which was blocked by PD98059, an mitogen-activated protein kinase kinase (MEK) inhibitor. Furthermore, overexpression of MEK1 or extracellular signal-regulated kinase 1 (ERK1) increased c-Jun expression and NT promoter activity. More importantly, PD98059 blocked rapamycin- or torin1-enhanced NT secretion. Consistently, rapamycin and torin1 also increased NT gene expression in Hep3B cells, a human hepatoma cell line that, similar to BON, expresses high levels of NT. Phosphorylation of c-Jun and ERK1/2 was also increased by rapamycin and torin1 in Hep3B cells. Finally, we showed activation of mTOR in BON cells treated with amino acids, high glucose, or serum and, concurrently, the attenuation of ERK1/2 and c-Jun phosphorylation and NT secretion. Together, mTORC1, as a nutrient sensor, negatively regulates NT secretion via the MEK/ERK/c-Jun signaling pathway. Our results identify a physiological link between mTORC1 and MEK/ERK signaling in controlling intestinal hormone gene expression and secretion.
MonetDBLite: An Embedded Analytical Database (2018)

While traditional RDBMSes offer a lot of advantages, they require significant effort to setup and to use. Because of these challenges, many data scientists and analysts have switched to using alternative data management solutions. These alternatives, however, lack features that are standard for RDBMSes, e.g. out-of-core query execution. In this paper, we introduce the embedded analytical database MonetDBLite. MonetDBLite is designed to be both highly efficient and easy to use in conjunction with standard analytical tools. It can be installed using standard package managers, and requires no configuration or server management. It is designed for OLAP scenarios, and offers near-instantaneous data transfer between the database and analytical tools, all the while maintaining the transactional guarantees and ACID properties of a standard relational system. These properties make MonetDBLite highly suitable as a storage engine for data used in analytics, machine learning and classification tasks.
Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression (2019)

ClinicalTrials.gov identifier: NCT02493868.
Stereospecific ligands and their complexes. I. A cobalt(III) complex of ethylenediaminedisuccinic acid (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific ligands and their complexes. I. A cobalt(III) complex of ethylenediaminedisuccinic acidJohn A. Neal and Norman J. RoseCite this: Inorg. Chem. 1968, 7, 11, 2405–2412Publication Date (Print):November 1, 1968Publication History Published online1 May 2002Published inissue 1 November 1968https://doi.org/10.1021/ic50069a043RIGHTS & PERMISSIONSArticle Views390Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (852 KB) Get e-Alertsclose Get e-Alerts
Quantitative MRI in patients with idiopathic generalized epilepsy. Evidence of widespread cerebral structural changes (1998)

In patients with idiopathic generalized epilepsy (IGE), visual inspection of routine MRI is normal. However, pathological studies have shown microdysgenesis in grey and white matter in a large percentage of autopsies from cases of IGE. Recently, widespread structural changes not evident on visual inspection of high resolution MRI have been shown using quantitative MRI in patients with apparently focal cerebral dysgenesis. We sought to determine whether similar quantitative changes might be present in patients with IGE, reflecting possible underlying structural abnormalities. Twenty patients with juvenile myoclonic epilepsy, 10 patients each with childhood absence epilepsy and juvenile absence epilepsy, five patients with tonic-clonic seizures on awakening and 30 control subjects had T1-weighted volume acquisition MRI scans on a 1.5T GE scanner. The cerebral hemispheres were segmented semi-automatically, allowing the comparison of normalized cortical and subcortical matter volumes between groups, and investigation of the regional distribution of cortical and subcortical matter in individual subjects. Patients with IGE had significantly larger cortical grey matter volumes than control subjects. Significant abnormalities of the regional distribution of cerebral grey and subcortical matter were found in eight out of 20 patients with juvenile myoclonic epilepsy, one out of 10 patients with childhood absence epilepsy, four out of 10 patients with juvenile absence epilepsy and two out of five patients with tonic-clonic seizures on awakening, but in none of the 30 control subjects. Using MRI-segmentation, we identified widespread cerebral structural changes in patients with various IGE syndromes. Quantitative MRI supports the existence of structural abnormalities in patients with IGE.
Improving Principal Direction Divisive Clustering (2013)

Clustering is a very important topic in machine learning and knowledge discovery research. Many methods have been proposed, each based on different assumptions and models. In this paper we propose an improvement of the Principal Direction Divisive Partitioning algorithm. The proposed algorithm merges concepts from density estimation and projection-based methods towards a fast and efficient clustering algorithm, capable of dealing with high dimensional data. Experimental results show improved partitioning performance compared to other popular methods. Moreover, we explore the problem of automatically determining the number of clusters that is central in cluster analysis.
Optimizing coordinated motion planning for multiple car-like robots on a segment of highway (2015)

SUMMARY Real-time responses for multiple robots motion planning demand heuristic algorithms. This paper presents a method to evaluate the efficiency of these algorithms in order to compute coordinated trajectories for multiple car-like robots on a segment of a highway. The idea is to compare the results of these algorithms with the optimal result obtained by a proposed mixed-integer linear programming (MILP) optimization model. The MILP model considers the main elements of a traffic system, such as topography of lanes, traffic rules and individual capacity of acceleration. Moreover, new indexes for microscopic traffic assessment are proposed a well. Several tests have been carried out to validate both the MILP model and the algorithm used.
Targeting the Cyclophilin Domain of Ran-binding Protein 2 (Ranbp2) with Novel Small Molecules to Control the Proteostasis of STAT3, hnRNPA2B1 and M-Opsin (2015)

Cyclophilins are peptidyl cis-trans prolyl isomerases (PPIases), whose activity is typically inhibited by cyclosporine A (CsA), a potent immunosuppressor. Cyclophilins are also chaperones. Emerging evidence supports that cyclophilins present nonoverlapping PPIase and chaperone activities. The proteostasis of the disease-relevant substrates, signal transducer and activator of transcription 3 and 5 (STAT3/STAT5), heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1), and M-opsin, is regulated by nonoverlapping chaperone and PPIase activities of the cyclophilin domain (CY) of Ranbp2, a multifunctional and modular scaffold that controls nucleocytoplasmic shuttling and proteostasis of selective substrates. Although highly homologous, CY and the archetypal cyclophilin A (CyPA) present distinct catalytic and CsA-binding activities owing to unique structural features between these cylophilins. We explored structural idiosyncrasies between CY and CyPA to screen in silico nearly 9 million small molecules (SM) against the CY PPIase pocket and identify SMs with selective bioactivity toward STAT3, hnRNPA2B1, or M-opsin proteostasis. We found three classes of SMs that enhance the cytokine-stimulated transcriptional activity of STAT3 without changing latent and activated STAT3 levels, down-regulate hnRNPA2B1 or M-opsin proteostasis, or a combination of these. Further, a SM that suppresses hnRNPA2B1 proteostasis also inhibits strongly and selectively the PPIase activity of CY. This study unravels chemical probes for multimodal regulation of CY of Ranbp2 and its substrates, and this regulation likely results in the allosterism stemming from the interconversion of conformational substates of cyclophilins. The results also demonstrate the feasibility of CY in drug discovery against disease-relevant substrates controlled by Ranbp2, and they open new opportunities for therapeutic interventions.
Lossless compression of AVIRIS images (1996)

Adaptive DPCM methods using linear prediction are described for the lossless compression of hyperspectral (224-band) images recorded by the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS). The methods have two stages-predictive decorrelation (which produces residuals) and residual encoding. Good predictors are described, whose performance closely approaches limits imposed by sensor noise. It is imperative that these predictors make use of the high spectral correlations between bands. The residuals are encoded using variable-length coding (VLC) methods, and compression is improved by using eight codebooks whose design depends on the sensor's noise characteristics. Rice (1979) coding has also been evaluated; it loses 0.02-0.05 b/pixel compression compared with better VLC methods but is much simpler and faster. Results for compressing ten AVIRIS images are reported.