gebhart/patrepeval huggingface dataset:
Musical Similarity and Commonness Estimation Based on Probabilistic Generative Models of Musical Elements (2016)

This paper proposes a novel concept we call musical commonness, which is the similarity of a song to a set of songs; in other words, its typicality. This commonness can be used to retrieve representative songs from a set of songs (e.g. songs released in the 80s or 90s). Previous research on musical similarity has compared two songs but has not evaluated the similarity of a song to a set of songs. The methods presented here for estimating the similarity and commonness of polyphonic musical audio signals are based on a unified framework of probabilistic generative modeling of four musical elements (vocal timbre, musical timbre, rhythm, and chord progression). To estimate the commonness, we use a generative model trained from a song set instead of estimating musical similarities of all possible song-pairs by using a model trained from each song. In experimental evaluation, we used two song-sets: 3278 Japanese popular music songs and 415 English songs. Twenty estimated song-pair similarities for each element and each song-set were compared with ratings by a musician. The comparison with the results of the expert ratings suggests that the proposed methods can estimate musical similarity appropriately. Estimated musical commonnesses are evaluated on basis of the Pearson product-moment correlation coefficients between the estimated commonness of each song and the number of songs having high similarity with the song. Results of commonness evaluation show that a song having higher commonness is similar to songs of a song set.
Function of plastidial pyruvate kinases in seeds of <i>Arabidopsis thaliana</i><sup>†</sup> (2007)

Pyruvate kinase (PK) catalyses the irreversible synthesis of pyruvate and ATP, which are both used in multiple biochemical pathways. These compounds are essential for sustained fatty acid production in the plastids of maturing Arabidopsis embryos. Using a real-time quantitative reverse transcriptase (RT)-PCR approach, the three genes encoding putative plastidial PKs (PKps) in Arabidopsis, namely PKp1 (At3g22960), PKp2 (At5g52920) and PKp3 (At1g32440), were shown to be ubiquitously expressed. However, only PKp1 and PKp2 exhibited significant expression in maturing seeds. The activity of PKp1 and PKp2 promoters was consistent with this pattern, and the study of the PKp1:GFP and PKp2:GFP fusion proteins confirmed the plastidial localization of these enzymes. To further investigate the function of these two PKp isoforms in seeds comprehensive functional analyses were carried out, including the cytological, biochemical and molecular characterization of two pkp1 and two pkp2 alleles, together with a pkp1pkp2 double mutant. The results obtained outlined the importance of these PKps for fatty acid synthesis and embryo development. Mutant seeds were depleted of oil, their fatty acid content was drastically modified, embryo elongation was retarded and, finally, seed germination was also affected. Together, these results provide interesting insights concerning the carbon fluxes leading to oil synthesis in maturing Arabidopsis seeds. The regulation of this metabolic network by the WRINKLED1 transcription factor is discussed, and emphasizes the role of plastidial metabolism and the importance of its tight regulation.
Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis (2015)

Hepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide because of its high incidence, its metastatic potential and the low efficacy of conventional treatment. Inactivation of apoptosis is implicated in tumour progression and chemotherapy resistance, and has been linked to the presence of endoplasmic reticulum stress. Melatonin, the main product of the pineal gland, exerts anti-proliferative, pro-apoptotic and anti-angiogenic effects in HCC cells, but these effects still need to be confirmed in animal models. Male Wistar rats in treatment groups received diethylnitrosamine (DEN) 50 mg/kg intraperitoneally twice/once a week for 18 weeks. Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration. Melatonin improved survival rates and successfully attenuated liver injury, as shown by histopathology, decreased levels of serum transaminases and reduced expression of placental glutathione S-transferase. Furthermore, melatonin treatment resulted in a significant increase of caspase 3, 8 and 9 activities, polyadenosine diphosphate (ADP) ribose polymerase (PARP) cleavage, and Bcl-associated X protein (Bax)/Bcl-2 ratio. Cytochrome c, p53 and Fas-L protein concentration were also significantly enhanced by melatonin. Melatonin induced an increased expression of activating transcription factor 6 (ATF6), C/EBP-homologous protein (CHOP) and immunoglobulin heavy chain-binding protein (BiP), while cyclooxygenase (COX)-2 expression decreased. Data obtained suggest that induction of apoptosis and ER stress contribute to the beneficial effects of melatonin in rats with DEN-induced HCC.
Recursive windowing for generating autocorrelation coefficients for LPC analysis (1981)

A method for recursively computing the autocorrelation estimates needed for LPC analysis in a vocoder environment has been developed theoretically and studied experimentally. The method has three specific advantages: 1) it requires very little memory for its implementation; 2) it is realized by a structure consisting of several identical modules; and 3) the effective window length may be changed without varying the structure. Experimental results showed the speech quality to be comparable to and slightly better than that produced by an auto-correlation LPC vocoder using a Hamming window.
Style Transfer Via Image Component Analysis (2013)

Example-based stylization provides an easy way of making artistic effects for images and videos. However, most existing methods do not consider the content and style separately. In this paper, we propose a style transfer algorithm via a novel component analysis approach, based on various image processing techniques. First, inspired by the steps of drawing a picture, an image is decomposed into three components: draft, paint and edge, which describe the content, main style, and strengthened strokes along the boundaries. Then the style is transferred from the template image to the source image in the paint and edge components. Style transfer is formulated as a global optimization problem by using Markov random fields, and a coarse-to-fine belief propagation algorithm is used to solve the optimization problem. To combine the draft component and the obtained style information, the final artistic result can be achieved via a reconstruction step. Compared to other algorithms, our method not only synthesizes the style, but also preserves the image content well. We also extend our algorithm from single image stylization to video personalization, by maintaining the temporal coherence and identifying faces in video sequences. The results indicate that our approach performs excellently in stylization and personalization for images and videos.
Quad Tilt Wing VTOL UAV: Aerodynamic Characteristics and Prototype Flight (2009)

A QTW VTOL UAV, featured tandem tilt wings and propellers mounted at the mid-span of each wing, is one of the most promising UAV configurations having both a VTOL capability and high cruise performance. A small prototype QTW UAV has been constructed to prove the concept and full transition between vertical and horizontal flight has been successfully demonstrated under remote manual control. The essential aerodynamic characteristics of the QTW derived from wind tunnel data are summarized in this paper, and a tandem wing concept which achieves both hovering and cruising stability has been applied to design the prototype UAV. A flight control system allowing continuous control through all flight phases enabled a pilot to perform vertical take-off, accelerating transition, cruise, decelerating transition and hover landing, with sufficient flying qualities.
Ocean thermal feature recognition, discrimination, and tracking using infrared satellite imagery (1992)

A method for quantitatively measuring ocean surface movement, using sequential 10.8- mu m-band AVHRR images, is presented. An ordered statistical edge detection algorithm is used to select ocean thermal pattern features by detecting and mapping gradients and at the same time discriminating between the water surface, land, and clouds. Use of edge detection to select features in this manner reduces the need to perform preprocess screening and masking to remove clouds and land. A constrained correlation based feature recognition scheme is then used to find the best match to the pattern feature in a subsequent image. Surface displacement direction and distance are calculated for each selected point with average period velocity being computed based on elapsed time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Purification of the muscarinic acetylcholine receptor from porcine brain. (1985)

The muscarinic acetylcholine receptor of porcine cerebrum has been purified to apparent homogeneity by affinity chromatography, with conjugated 3-(2'-aminobenzhydryloxy)tropane (ABT) as described previously (Haga, K., and Haga, T. (1983) J. Biol. Chem. 258, 13575-13579). In a single step purification using 900 ml of digitonin/cholate-solubilized preparations and 300 ml of the ABT-agarose gel, we obtained, in a yield of 10-15%, more than 250 pmol of muscarinic receptors which bind [3H]N-methylscopolamine with a specific activity of 1,000-5,000 pmol/mg of protein (1,000-5,000-fold purification). The muscarinic receptors eluted from the ABT-agarose gel with 0.1 mM atropine were adsorbed to hydroxylapatite and then recovered as a concentrated solution. Muscarinic receptors were further purified by rechromatography with the same gel or by gel permeation high pressure liquid chromatography. The amino acid composition of the purified receptor was determined, and the specific activity of the purified preparation was estimated to be 13,100 pmol/mg of protein on the basis of amino acid composition. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified receptors with or without radioiodination revealed a single, major band with an apparent Mr of 70,000 either by silver staining or radioautogram. The major band corresponded to the band which specifically bound [3H]propylbenzylcholine mustard (irreversible muscarinic ligand). The purified receptor showed essentially the same specificity for muscarinic ligands as unpurified receptors.
An active tissue-contrast sensing microsystem for biopsy needles: Initial results (2011)

This paper describes progress toward an active tissue-contrast sensing microsystem that can be embedded at the tip of a fine biopsy needle. An analog CMOS chip is integrated with a piezoelectric sensor to reduce the impact of parasitic capacitances and allow differential sensing that will permit deep tissue sampling. The sensor element and the CMOS circuit are fabricated in-house and integrated onto the tip of a 20-gauge needle. The sensor module with integrated interface circuit has a size of 950 μm (L) × 350 μm (W) × 220 μm (H). It can successfully generate an oscillating signal as the readout of the integrated piezoelectric quartz sensor. Preliminary functional verification for sensing is provided by saline solutions of 0.5-3% concentration, representing a progressive increase of acoustic impedance. As expected the measured frequency shifts increase with higher saline concentration, indicating the validity of the sensor interface circuit design.
Effect of different moisturizers on SLS‐irritated human skin (2001)

Moisturizers are widely used to treat irritant contact dermatitis (ICD). Their use is, however, not well-documented and standardized models for testing skin care products are needed to acquire documentation of their efficacy. The present study was undertaken to evaluate the effect of 6 commonly-used moisturizers on the recovery of irritated human skin. No commercial interests were involved in the study. 36 healthy volunteers had patch tests with SLS 0.5% applied on their forearms/upper arms for 24 h. After irritation of the skin, all volunteers had a moisturizer applied on one forearm/upper arm, respectively, 3 x daily for the following 5 days. The other forearm/upper arm served as an untreated control. Each moisturizer was tested on 12 volunteers and each volunteer tested 2 moisturizers at the same time. Evaluation was done on days 1, 3 and 8 by transepidermal water loss, electrical capacitance, laser Doppler flowmetry, DermaSpectrometry and clinical scoring. All 6 moisturizers were found to accelerate regeneration of the skin barrier function when compared to irritated non-treated skin. The most lipid-rich moisturizers improved barrier restoration more rapidly than the less lipid-rich moisturizers. We suggest this experimental model for further moisturizer efficacy testing.
Purification and Characterization of Membrane-Bound Phospholipase A2 from Rat Platelets1 (1988)

Phospholipase A2 was solubilized from rat platelet membrane by 1 M KCl and purified to near homogeneity on sodium dodecyl sulfate-polyacrylamide gel electrophoresis and HPLC. The characteristics of the purified membrane-bound enzyme were compared with those of phospholipase A2 released from thrombin-stimulated rat platelets (Horigome, K., Hayakawa, M., Inoue, K., & Nojima, S. (1987) J. Biochem. 101, 625-631). The molecular weights, elution profiles on reversed-phase HPLC, and NH2-terminal sequences were identical for the two enzymes. Other characteristics of the two enzymes, such as specific activity, substrate specificity, pH optimum, Ca2+ requirement, heat lability, and sensitivity to p-bromophenacyl bromide were also indistinguishable. These findings suggest that both enzymes share a common structure.
Effects of cellular ATP depletion on glucose transport and insulin signaling in 3T3-L1 adipocytes (2001)

Glucosamine induced insulin resistance in 3T3-L1 adipocytes, which was associated with a 15% decrease in cellular ATP content. To study the role of ATP depletion in insulin resistance, we employed sodium azide (NaN3) and dinitrophenol (DNP), which affect mitochondrial oxidative phosphorylation, to achieve a similar 15% ATP depletion. Unlike glucosamine, NaN3 and DNP markedly increased basal glucose transport, and the increased basal glucose transport was associated with increased GLUT-1 content in the plasma membrane without changes in total GLUT-1 content. These agents, like glucosamine, did not affect the early insulin signaling that is implicated in insulin stimulation of glucose transport. In cells with a severe 40% ATP depletion, basal glucose transport was similarly elevated, and insulin-stimulated glucose transport was similar in cells with 15% ATP depletion. In these cells, however, early insulin signaling was severely diminished. These data suggest that cellular ATP depletion by glucosamine, NaN3, and DNP exerts differential effects on basal and insulin-stimulated glucose transport and that ATP depletion per se does not induce insulin resistance in 3T3-L1 adipocytes.
Evolution of perturbations of squashed Kaluza-Klein black holes: Escape from instability (2008)

The squashed Kaluza-Klien (KK) black holes differ from the Schwarzschild black holes with asymptotic flatness or the black strings even at energies for which the KK modes are not excited yet, so that squashed KK black holes open a window in higher dimensions. Another important feature is that the squashed KK black holes are apparently stable and, thereby, let us avoid the Gregory-Laflamme instability. In the present paper, the evolution of scalar and gravitational perturbations in time and frequency domains is considered for these squashed KK black holes. The scalar field perturbations are analyzed for general rotating squashed KK black holes. Gravitational perturbations for the so-called zero mode are shown to be decayed for nonrotating black holes, in concordance with the stability of the squashed KK black holes. The correlation of quasinormal frequencies with the size of extra dimension is discussed.
Structural basis for autoinhibition and activation of Auto, a virulence‐associated peptidoglycan hydrolase of <i>Listeria monocytogenes</i> (2009)

During a bacterial infection, each successive step is orchestrated by a dedicated set of virulence factors. In Gram-positive bacteria, the presentation or release of such factors is crucially dependent on the continual remodelling of the cell wall. We have investigated the autolysin or peptidoglycan hydrolase Auto (Lmo1076) from the human pathogen Listeria monocytogenes to structurally and biochemically underpin its role in host cell invasion. We demonstrate that Auto is an N-acetylglucosaminidase, that it is autoinhibited when newly secreted but activated by proteolytic cleavage, that it has an acidic pH optimum and that it preferentially cleaves acetylated over de-acetylated peptidoglycan. The crystal structure of Auto, the first for glycoside hydrolase family 73, and the first for a listerial autolysin, indicates that autoinhibition is due to an N-terminal alpha-helix unique to Auto that physically blocks the substrate-binding cleft. We identify Glu122 and Glu156 as the two catalytically essential carboxylate groups. The physical properties of Auto as well as its localization to lipoteichoic acid by its four C-terminal GW modules imply cell wall degradation by Auto to be highly co-ordinated. Its spatio-temporally controlled activation and localized activity in an acidified environment indicate that it facilitates remodelling of the cell wall and may be involved in co-ordinating the release of virulence factors at specific stages of an infection.
Monolithic multiwavelength lasers for WDM lightwave systems (1997)

We review the progress of multiwavelength DFB laser arrays made for multiwavelength optical networks. The goal is to reduce the per-wavelength transmitter cost in manufacturing and network element control. Using photonic integration, we have addressed and resolved several important issues related to laser arrays such as wavelength accuracy, output power and optical packaging. State of the art results are summarized and its impact on the multiwavelength optical network is assessed.
CcpNmr AnalysisAssign: a flexible platform for integrated NMR analysis (2016)

NMR spectroscopy is an indispensably powerful technique for the analysis of biomolecules under ambient conditions, both for structural- and functional studies. However, in practice the complexity of the technique has often frustrated its application by non-specialists. In this paper, we present CcpNmr version-3, the latest software release from the Collaborative Computational Project for NMR, for all aspects of NMR data analysis, including liquid- and solid-state NMR data. This software has been designed to be simple, functional and flexible, and aims to ensure that routine tasks can be performed in a straightforward manner. We have designed the software according to modern software engineering principles and leveraged the capabilities of modern graphics libraries to simplify a variety of data analysis tasks. We describe the process of backbone assignment as an example of the flexibility and simplicity of implementing workflows, as well as the toolkit used to create the necessary graphics for this workflow. The package can be downloaded from www.ccpn.ac.uk/v3-software/downloads and is freely available to all non-profit organisations.
AUTOMATED ATLAS-BASED 3D SEGMENTATION OF THE METASTATIC SPINE (2008)

Purpose: Effectively quantifying metastatic tumour involvement in the spine requires accurate vertebral segmentation. Automated techniques such as thresholding or region growing have difficulty defining boundaries between tumour tissue and surrounding soft tissue if lytic disease breaches the vertebral cortical shell. It is hypothesized that the application of image registration techniques may afford a potential solution to automating segmentation of metastically-involved vertebrae with cortical shell destruction. The objective of this study is to validate deformable registration as a means to automate the segmentation of tumour-bearing vertebrae through the transformation of atlas segmentations. Methods: CT scans were collected from 6 patients (T4-L5) with spinal metastases secondary to breast cancer. Healthy levels from the patients were cropped and segmented using a combination of thresholding and manual delineation (Amira 3.1.1, TGS Berlin) to obtain the atlas for each vertebral level. After spatial alignment, metastatically involved vertebral levels were segmented by a registration of the atlas scan by automated affine registration (Amira) and refined by demons deformable registration (ITK, NLM Bethesda). The algorithm was tested through comparison of 10 vertebral bodies (thoracic and lumbar) segmented using the automated approach against a gold standard segmentation produced by semi-manual thresholding. The quality of the automatic segmentation was determined by calculating how many voxels were concurrently within both automatic and manual segmentation of the scan. Results: Deformable registration successfully segmented metastatically involved vertebrae with and without breach of the cortical shell. Similar performance was evident when using an atlas from an adjacent level as compared to using an atlas of the identical vertebral level. Quality of the automatic segmentation ranged from 87.67%–96.22% concurrency. Comparisons of inter-user semi-manual segmentations yielded a similar maximum of 96% concurrency. Analysis speed was 10 to 15 times faster using the automated technique. Conclusions: By maintaining the atlas morphology, atlas-based segmentations are able to accurately differentiate between trans-cortical tumours and surrounding soft tissue, overcoming problems inherent to more conventional automated segmentation techniques. Clinical application of this segmentation algorithm centers on tumour quantification and tracking progression of treatment effect and metastatic disease pathology. Funding : Other Education Grant Funding Parties : Canadian Breast Cancer Research Alliance, Sunnybrook & Women`s College Research Institute
Low-dose paroxetine 7.5 mg for menopausal vasomotor symptoms (2013)

Paroxetine 7.5 mg is well-tolerated, is effective in reducing the frequency and severity of menopausal vasomotor symptoms, and demonstrates persistence of treatment benefit through 24 weeks of treatment.
H<sub>2</sub>Evolution from Water on Modified Cu<sub>2</sub>ZnSnS<sub>4</sub>Photoelectrode under Solar Light (2010)

Cu2ZnSnS4 (CZTS) thin films were investigated as photoelectrodes for H2 evolution from water under solar light. Surface modifications with Pt, CdS, and TiO2 enhanced the incident photon-to-current conversion efficiency of CZTS thin film electrode for H2 production from water by three orders of magnitude to 40% (λ= 600 nm). The solar energy conversion efficiency in H2 production using modified CZTS reached 1.2%. Our results demonstrate that the photoelectrochemical properties of CZTS were significantly improved by surface modification, which suggests the feasibility of CZTS as a photocathode for a photoelectrochemical water-splitting system.
Nonlinear Phase Noise Reduction of DQPSK Signals by a Phase-Preserving Amplitude Limiter Using Four-Wave Mixing in Fiber (2008)

It is experimentally shown that phase-preserving amplitude regeneration by an all-optical amplitude limiter using saturation of four-wave mixing in a highly nonlinear fiber can enhance differential quadrature phase-shift keying (DQPSK) transmission performance. The limiter suppresses amplitude fluctuations of the signal, by which the nonlinear phase variance caused by self-phase modulation in the transmission fiber is reduced. The 10-GSymbol/s short-pulse DQPSK transmission experiment over densely dispersion-managed fiber shows that the amplitude limitation after an imperfect transmitter increases maximum transmitted signal power by 5 dB.