gebhart/patrepeval huggingface dataset:
Strip mining on SIMD architectures (1991)

Article Free Access Share on Strip mining on SIMD architectures Author: Michael Weiss Compass, Inc., 550 Edgewater Dr., Wakefield, MA Compass, Inc., 550 Edgewater Dr., Wakefield, MAView Profile Authors Info & Claims ICS '91: Proceedings of the 5th international conference on SupercomputingJune 1991Pages 234–243https://doi.org/10.1145/109025.109083Published:01 June 1991Publication History 18citation1,818DownloadsMetricsTotal Citations18Total Downloads1,818Last 12 Months527Last 6 weeks33 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Publisher SiteeReaderPDF
A Reliability Model for the Detection of Electronic Watermarks in Digital Images; Symposium on Communications and Vehicular Technology (5th) Held in Enschede, The Netherlands on Oct 1997 (1997)

A watermark is a perceptually unobstructive mark embedded in an image, audio or video clip or other multimedia asset. A watermark can carry additional information, for instance about the source and copyright status of a document or its intended recipient, its rights and restrictions. We analyze the reliability of detecting such watermarks, modeling it as a detection problem where the original content acts as noise or interference. Probabilities of incorrect detections are expressed in terms of the watermark-to-image power ratio, showing a significant similarity in the problem of detecting watermarks and interference. Theoretical results are verified by experiments.
Editorial Comment (1992)

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SmartSkin (2002)

This paper introduces a new sensor architecture for making interactive surfaces that are sensitive to human hand and finger gestures. This sensor recognizes multiple hand positions and shapes and calculates the distance between the hand and the surface by using capacitive sensing and a mesh-shaped antenna. In contrast to camera-based gesture recognition systems, all sensing elements can be integrated within the surface, and this method does not suffer from lighting and occlusion problems. This paper describes the sensor architecture, as well as two working prototype systems: a table-size system and a tablet-size system. It also describes several interaction techniques that would be difficult to perform without using this architecture
40 Gbit/s soliton transmission field experimentover 1360 kmusing in-line soliton control (1998)

In-line synchronous modulation was employed for the first time in a soliton transmission field experiment to extend the transmission distance. The transmission distance without in-line control was 1000 km and was extended to 1360 km by installing an in-line controller at 680 km.
Platelet Coagulation-Protein Interactions (2004)

The biochemical mechanisms by which activated platelets participate in exposing receptors for the assembly of enzyme-cofactor-substrate complexes at all stages of the blood coagulation cascade are reviewed. Information derived from studies conducted during the last 30 years supports the concept that the initiation of blood coagulation is triggered by exposure of tissue factor at injury sites, leading to the generation of minute quantities of thrombin (limited by tissue factor pathway inhibitor), sufficient to activate platelets, factors XI, VIII, and V, and trigger the consolidation pathway (i.e., the sequential activation of factors XI, IX, X, and prothrombin on the activated platelet surface), leading to the generation of sufficient thrombin to convert fibrinogen to fibrin and effect hemostasis. Platelets localize coagulation to the hemostatic thrombus and protect coagulation enzymes from inhibition by both plasma and platelet inhibitors (e.g., protease nexin 2), thus preventing disseminated intravascular coagulation.
The effect of natural habituation on coagulation responses to acute mental stress and recovery in men (2004)

Blood coagulation activation might be one mechanism linking acute mental stress with coronary events. We investigated the natural habituation of coagulation responses and recovery to short-term mental stress. Three times with one-week intervals, 24 men (mean age 47 +/- 7 years) underwent the same 13-min stressor (preparation, job interview, mental arithmetic). During each visit venous blood was obtained four times (baseline, immediately post-stress, 45 min of recovery, 105 min of recovery). Eight blood coagulation parameters were measured at weeks one and three. Acute stress provoked increases in von Willebrand factor antigen, fibrinogen, clotting factor FVII activity (FVII:C), FVIII:C, FXII:C (p's < or = 0.019), and D-dimer (N.S.). All coagulation parameters experienced full recovery except FVIII:C (p = 0.022). Stress did not significantly affect activated partial thromboplastin time and prothrombin time. At all time points FVIII:C and FXII:C levels were significantly higher at week one compared to week three (p's < or = 0.041). Before catheter insertion, systolic blood pressure (p = 0.001) and heart rate (p = 0.026) were relatively higher at week one. Unlike the magnitude of systolic blood pressure response to stress (p = 0.007) and of cortisol recovery from stress (p = 0.002), the magnitude of all coagulation responses to stress and the recovery from stress were similar in week one and week three. Sympathetic activation with anticipatory stress best explained increased baseline activity in FVIII and FXII at week one. An incapacity of the coagulation system to adapt to stress repeats is perhaps a consequence of evolution, but might also contribute to increased coronary risk in some individuals, particularly in those with cardiovascular diseases.
Current Concepts in the Management of Necrotizing Fasciitis (2014)

Necrotizing fasciitis (NF) is a severe, rare, potentially lethal soft tissue infection that develops in the scrotum and perineum, the abdominal wall, or the extremities. The infection progresses rapidly, and septic shock may ensue; hence, the mortality rate is high (median mortality 32.2%). Prognosis becomes poorer in the presence of co-morbidities, such as diabetes mellitus, immunosuppression, chronic alcohol disease, chronic renal failure, and liver cirrhosis. NF is classified into four types, depending on microbiological findings. Most cases are polymicrobial, classed as type I. The clinical status of the patient varies from erythema, swelling, and tenderness in the early stage to skin ischemia with blisters and bullae in the advanced stage of infection. In its fulminant form, the patient is critically ill with signs and symptoms of severe septic shock and multiple organ dysfunction. The clinical condition is the most important clue for diagnosis. However, in equivocal cases, the diagnosis and severity of the infection can be secured with laboratory-based scoring systems, such as the laboratory risk indicator for necrotizing fasciitis score or Fournier's gangrene severity index score, especially in regard to Fournier's gangrene. Computed tomography or ultrasonography can be helpful, but definitive diagnosis is attained by exploratory surgery at the infected sites. Management of the infection begins with broad-spectrum antibiotics, but early and aggressive drainage and meticulous debridement constitute the mainstay of treatment. Postoperative management of the surgical wound is also important for the patient's survival, along with proper nutrition. The vacuum-assisted closure system has proved to be helpful in wound management, with its combined benefits of continuous cleansing of the wound and the formation of granulation tissue.
Preparation of Functionally PEGylated Gold Nanoparticles with Narrow Distribution through Autoreduction of Auric Cation by α-Biotinyl-PEG-<i>block</i>-[poly(2-(<i>N,N</i>-dimethylamino)ethyl methacrylate)] (2003)

PEGylated gold nanoparticles with biotin moieties installed at the distal end of the PEG tethered chains were prepared by the autoreduction of HAuCl4 catalyzed by alpha-biotinyl-PEG-block-poly[2-(N,N-dimethylamino)ethyl methacrylate] (biotinyl-PEG/PAMA) in aqueous medium at room temperature. The size of the gold nanoparticles was controllable in a range of 6-13 nm by changing the initial Au3+/polymer ratio, while retaining their narrow size distribution. The dispersion stability of the nanoparticles in aqueous medium was extremely high even under the condition of salt concentration as high as I = 2.0. Biotinyl-PEG/PAMA-anchored gold nanoparticles underwent specific aggregation in the presence of streptavidin, revealing their promising utility as colloidal sensing systems applicable under biological condition.
A Convenient Synthesis of Tricyclic 2-Quinolizidones<sup>1</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Convenient Synthesis of Tricyclic 2-Quinolizidones1Leon Mandell, B. A. Hall, and K. P. SinghCite this: J. Org. Chem. 1964, 29, 10, 3067–3068Publication Date (Print):October 1, 1964Publication History Published online1 May 2002Published inissue 1 October 1964https://doi.org/10.1021/jo01033a504RIGHTS & PERMISSIONSArticle Views77Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (287 KB) Get e-Alerts Get e-Alerts
A Low-Loss, Bidirectional Optical Rotary Joint For Fiber-Optic Applications (1984)

The interconnection of fiber-optic transmission lines to rotating devices requires the development of a continuously rotatable, low-loss, bidirectional optical rotary joint. This paper discusses the physical properties and optical performance of a rotary joint that will accommodate a single optical fiber with graded index profile and 50-micrometer core size. The device was developed for the Naval Research Laboratory by ITT, Electro-Optical Products Division to mechanically decouple optical fibers exiting from a rotating cable-winch system. For this specific application, a rotary joint can be used at each end of the winch axle, thereby allowing access to a total of two optical fibers. Since many uses of a rotary joint require the transfer of both electrical and optical power, the optical joint was incorporated into the housing of a 7-band, 10 Ampere (each) electrical slip-ring assembly provided by Electro-Tec Corporation. mhe nrecision bearings in the slip-ring housing provided a mechanical runout of less than .013 mm and an angular variation no greater than 0.2 degrees. Beam expansion and collimation techniques were used to reduce the dependence of optical loss on longitudinal and transverse offset at the rotational interface. Two quarter-pitch SELFOC rod lenses of 1 mm diameter, obtained from NSG, America, were used to achieve the beam expansion and collimation. The optical leads to the rotary joint were in the form of an unterminated single-fiber cable of approximately one meter length having a KEVLAR aramid sheath and a polyurethane overjacket. The maximum optical insertion loss at any rotational position was 1.3 dB at 830 nm and less than 1.7 dB at 1300 nm. The variation of insertion loss caused by device rotation was less than 0.25 dB at both wavelengths. At the conclusion of an endurance test of 310,000 revolutions at a 30 RPM rate, no degradation in performance could be observed.
WNK4 regulates apical and basolateral Cl <sup>–</sup> flux in extrarenal epithelia (2004)

Mutations in the serine-threonine kinase WNK4 [with no lysine (K) 4] cause pseudohypoaldosteronism type II, a Mendelian disease featuring hypertension with hyperkalemia. In the kidney, WNK4 regulates the balance between NaCl reabsorption and K(+) secretion via variable inhibition of the thiazide-sensistive NaCl cotransporter and the K(+) channel ROMK. We now demonstrate expression of WNK4 mRNA and protein outside the kidney. In extrarenal tissues, WNK4 is found almost exclusively in polarized epithelia, variably associating with tight junctions, lateral membranes, and cytoplasm. Epithelia expressing WNK4 include sweat ducts, colonic crypts, pancreatic ducts, bile ducts, and epididymis. WNK4 is also expressed in the specialized endothelium of the blood-brain barrier. These epithelia and endothelium all play important roles in Cl(-) transport. Because WNK4 is known to regulate renal Cl(-) handling, we tested WNK4's effect on the activity of mediators of epithelial Cl(-) flux whose extrarenal expression overlaps with WNK4. WNK4 proved to be a potent inhibitor of the activity of both the Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) and the Cl(-)/base exchanger SLC26A6 (CFEX) (>95% inhibition of NKCC1-mediated (86)Rb influx, P < 0.001; >80% inhibition of CFEX-mediated [(14)C] formate uptake, P < 0.001), mediators of Cl(-) flux across basolateral and apical membranes, respectively. In contrast, WNK4 showed no inhibition of pendrin, a related Cl(-)/base exchanger. These findings indicate a general role for WNK4 in the regulation of electrolyte flux in diverse epithelia. Moreover, they reveal that WNK4 regulates the activities of a diverse group of structurally unrelated ion channels, cotransporters, and exchangers.
Zinc and titanium oxides: promising UV-absorbers but what influence do they have on the intact skin? (1997)

Suspensions (20%) of microfine and ACS grade zinc oxide, or 20% titanium oxide in water, castor oil or polyethylene glycol were applied topically to rabbit skin over 4 h (1 day) or 2 h daily (3 days). Skin sites were analysed for metal uptake. Percutaneous absorption of the oxides was probably low, most remaining on the skin surface. Uptake patterns were influenced by the vehicles used. Appreciably more microfine zinc oxide was taken up by the skin in subacute studies. Local changes in trace metal concentration were construed as evidence of percutaneous absorption of zinc and titanium oxides. Further studies are indicated to validate the significance of these preliminary observations.
Evaluating functional network inference using simulations of complexbiological systems (2002)

Abstract Motivation: Although many network inference algorithms have been presented in the bioinformatics literature, no suitable approach has been formulated for evaluating their effectiveness at recovering models of complex biological systems from limited data. To overcome this limitation, we propose an approach to evaluate network inference algorithms according to their ability to recover a complex functional network from biologically reasonable simulated data. Results: We designed a simulator to generate data representing a complex biological system at multiple levels of organization: behaviour, neural anatomy, brain electrophysiology, and gene expression of songbirds. About 90% of the simulated variables are unregulated by other variables in the system and are included simply as distracters. We sampled the simulated data at intervals as one would sample from a biological system in practice, and then used the sampled data to evaluate the effectiveness of an algorithm we developed for functional network inference. We found that our algorithm is highly effective at recovering the functional network structure of the simulated system—including the irrelevance of unregulated variables—from sampled data alone. To assess the reproducibility of these results, we tested our inference algorithm on 50 separately simulated sets of data and it consistently recovered almost perfectly the complex functional network structure underlying the simulated data. To our knowledge, this is the first approach for evaluating the effectiveness of functional network inference algorithms at recovering models from limited data. Our simulation approach also enables researchers a priori to design experiments and data-collection protocols that are amenable to functional network inference. Availability: Source code and simulated data are available upon request. Contact: amink@cs.duke.eduasmith@neuro.duke.edujarvis@neuro.duke.edu
Perceptually based linear predictive analysis of speech (2005)

A novel speech analysis method which uses several established psychoacoustic concepts, the perceptually based linear predictive analysis (PLP), models the auditory spectrum by the spectrum of the low-order all-pole model. The auditory spectrum is derived from the speech waveform by critical-band filtering, equal-loudness curve pre-emphasis, and intensity-loudness root compression. We demonstrate through analysis of both synthetic and natural speech that psychoacoustic concepts of spectral auditory integration in vowel perception, namely the F1, F2' concept of Carlson and Fant and the 3.5 Bark auditory integration concept of Chistovich, are well modeled by the PLP method. A complete speech analysis-synthesis system based on the PLP method is also described in the paper.
Mechanism of Host Defense Suppression Induced by Viral Infection: Mode of Action of Inosiplex as an Antiviral Agent (1982)

The mechanism of influenza virus (INFV)-induced immunosuppression and the mode of inosiplex action against INFV infection were studied. INFV suppressed both anti-lipopolysaccharide and anti-sheep erythrocyte antibody production in mice. INFV infection caused viral mRNA synthesis and increased total RNA synthesis in lymphocytes, but total mRNA synthesis was decreased. The translational ability of INFV-infected lymphocytes was also suppressed. Thus, INFV seemed to cause suppression of both mRNA synthesis and the translational ability of lymphocytes, resulting in suppression of lymphocyte functions. Inosiplex potentiated antibody production against sheep erythrocytes but not against lipopolysaccharide in normal and INFV-infected mice. Adamantanamine did not produce such a potentiating effect. The lymphocytes obtained from INFV-immunized and inosiplex-treated mice conferred resistance against INFV infection. This resistance was partially inhibited by anti-Thy 1.2 antibody treatment of the lymphocytes. In an adoptive cell transfer system, inosiplex treatment of T-cell donors potentiated antibody production when a non-immunosuppressive carrier (human serum albumin) was used. When an immunosuppressive carrier (INFV) was used, inosiplex treatment of either B-cell donors or T-cell donors increased antibody production. Direct introduction of inosiplex into lymphocytes by a cell fusion technique stimulated anti-sheep erythrocyte antibody production more effectively than the addition of inosiplex to cultures. Inosiplex increased total RNA and total mRNA syntheses in phytohemagglutinin-treated lymphocytes. In INFV-infected lymphocytes, inosiplex decreased syntheses of total RNA, total mRNA, and viral mRNA and restored translational ability. From these results, we concluded that inosiplex penetrates into lymphocytes and suppresses viral RNA synthesis and that it supports lymphocyte functions by promoting RNA synthesis and translational ability, both of which are necessary for hosts.
Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARγ pathway (2007)

Growth hormone-deficient (GHD) patients show a decreased number of adipocytes, which is normalized by GH replacement, indicating an adipogenic effect of GH. However, the precise mechanisms underlying this effect remain to be clarified. In this study, we investigated the adipogenic effect of GH. GH stimulated MDI (3-isobutyl-1-methylxanthine, dexamethasone, and insulin)-induced adipogenesis of 3T3-L1 cells with early induction of peroxisome proliferator-activated receptors (PPAR)γ2 expression. This adipogenic effect of GH was suppressed by overexpression of Stat5A mutant (Stat5A-Y694F), a transcriptional suppressor for the GH–Stat5A/5B signaling pathway, with the reduction of PPARγ2 expression. Next, we investigated the relationship between Stat5A/5B and CCAAT/enhancer binding protein (C/EBP)β/δ orPPARγ in 3T3-L1 cells. Stat5A/5B stimulated C/EBPβ- and C/EBPδ-induced adipogenesis with enhancement of PPARγ2 expression. In addition, Stat5A/5B enhanced the transcriptional activity of C/EBPβ/δ in the PPARγ gene promoter. Furthermore, Stat5A/5B stimulated PPARγ-induced adipogenesis and enhanced the transcriptional activity of PPARγ. These results suggest that the GH–Stat5A/5B signaling pathway stimulates adipogenesis in cooperation with C/EBPβ/δ and PPARγ. To completely understand the effect of GH, cDNA microarray analysis was performed to screen genes affected by GH during MDI-induced adipogenesis. Among 4277 genes, 18 and 19 genes were up- and down-regulated respectively. cDNA microarray analysis also indicated the up-regulation of PPARγ and the modulation of expression of genes coding for growth factors or growth factor receptors, suggesting that GH stimulates adipogenesis in association with the modulation of cell growth. Thus, the GH–Stat5A/B signaling pathway stimulates adipogenesis through two distinct steps. In addition, cDNA microarray data provide us the further insights underlying the adipogenic effect of GH.
A bactericidal monoclonal antibody specific for the lipooligosaccharide of Bordetella pertussis reduces colonization of the respiratory tract of mice after aerosol infection with B. pertussis (1992)

A mouse immunoglobulin G3 monoclonal antibody specific for the core oligosaccharide moiety of the lipooligosaccharide (LOS) of Bordetella pertussis has been shown to have complement-dependent bactericidal activity. This monoclonal antibody exhibits bactericidal activity against strains of B. pertussis that express the LOS A phenotype. In addition this monoclonal antibody was effective in reducing colonization by B. pertussis in both the lungs and tracheas of mice after aerosol infection.