gebhart/patrepeval huggingface dataset:
Effects of 5-methylpyrazole-3-carboxylic acid on adipose tissue. I. Inhibition of lipolysis, effects on glucose, fructose, and glycogen metabolism in vitro and comparison with insulin. (1967)

5-Methylpyrazole-3-carboxylic acid in concentrations between 10-8 and 10-6 M inhibited the glycerol release of adipose tissue of fasted-refed rats. Insulin and 5-methylpyrazole-3-carboxylic acid partially prevented the loss of glycogen even in the absence of any substrate in the medium. Maximal glycogen turnover in vitro in the presence of glucose, fructose, and insulin amounted to 5 µmoles of hexose per gram per hour. 5-Methylpyrazole-3-carboxylic acid stimulated the incorporation of fructose-U-14C into glycogen out of proportion to its effects on overall fructose metabolism. This effect was counteracted by insulin but not by phlorizin. Insulin doubled fructose uptake of adipose tissue of fasted-refed rats but did not stimulate the incorporation of fructose-U-14C into glycogen. It stimulated the incorporation of glucose-U-14C into glycogen only at high rates of glucose uptake. These results support the concept that insulin and 5-methylpyrazole-3-carboxylic acid inhibit phosphorylase and increase glycogen synthetase activity. The difference between the activity of these two substances could best be explained by the existence of different pools of glucose 6-phosphate.
A parametrically controlled spectral analysis system for speech (1974)

The parametrically controlled analyzer (PCA) is a large PL/I program which has been designed to perform spectral analysis of speech signals. PCA features parametric selection of several analysis methods, including discrete Fourier transformation and linear predictive coding. Also, selection may be made among various smoothing, normalization, and interpolation methods. PCA develops high-quality spectrographic representations of speech for standard line printers and CRT displays. The PCA is described and numerous examples of various parameter settings are presented and discussed.
Correlation Between Uracil and Dihydrouracil Plasma Ratio, Fluorouracil (5-FU) Pharmacokinetic Parameters, and Tolerance in Patients With Advanced Colorectal Cancer: A Potential Interest for Predicting 5-FU Toxicity and Determining Optimal 5-FU Dosage (1999)

The UH(2)-U ratio, easily determined before treatment, could help to identify patients with metabolic deficiency and, therefore, a risk of toxicity.
Versatile processor design for efficiency and high performance (2002)

New architectural concepts are introduced for uniprocessor designs that conform to the data-driven computation paradigm. Usage of our D/sup 2/-CPU (Data-Driven processor) follows the natural flow of programs, minimizes the number of redundant operations, lowers the hardware cost, and reduces the power consumption. Instructions enter the processing unit when they are ready to execute or when all their operand(s) are to be available within a few clock cycles. This approach results in outstanding performance and elimination of large numbers of redundant operations that plague current processor designs. A comparative analysis of our design with conventional designs proves that it is capable of better performance and higher efficiency.
If you don't ask (about memory), they probably won't tell. (2008)

Memory impairment is a common complaint among elderly patients in general practice, but many patients will not present with these symptoms. It may be useful for general practitioners to ask about memory problems in order to identify potentially frail patients. Prospective trials are warranted.
Forecasting with twitter data (2013)

The dramatic rise in the use of social network platforms such as Facebook or Twitter has resulted in the availability of vast and growing user-contributed repositories of data. Exploiting this data by extracting useful information from it has become a great challenge in data mining and knowledge discovery. A recently popular way of extracting useful information from social network platforms is to build indicators, often in the form of a time series, of general public mood by means of sentiment analysis. Such indicators have been shown to correlate with a diverse variety of phenomena. In this article we follow this line of work and set out to assess, in a rigorous manner, whether a public sentiment indicator extracted from daily Twitter messages can indeed improve the forecasting of social, economic, or commercial indicators. To this end we have collected and processed a large amount of Twitter posts from March 2011 to the present date for two very different domains: stock market and movie box office revenue . For each of these domains, we build and evaluate forecasting models for several target time series both using and ignoring the Twitter-related data. If Twitter does help, then this should be reflected in the fact that the predictions of models that use Twitter-related data are better than the models that do not use this data. By systematically varying the models that we use and their parameters, together with other tuning factors such as lag or the way in which we build our Twitter sentiment index, we obtain a large dataset that allows us to test our hypothesis under different experimental conditions. Using a novel decision-tree-based technique that we call summary tree we are able to mine this large dataset and obtain automatically those configurations that lead to an improvement in the prediction power of our forecasting models. As a general result, we have seen that nonlinear models do take advantage of Twitter data when forecasting trends in volatility indices, while linear ones fail systematically when forecasting any kind of financial time series. In the case of predicting box office revenue trend, it is support vector machines that make best use of Twitter data. In addition, we conduct statistical tests to determine the relation between our Twitter time series and the different target time series.
Lipopolysaccharide Analogs Improve Efficacy of Acellular Pertussis Vaccine and Reduce Type I Hypersensitivity in Mice (2007)

Pertussis is an infectious disease of the respiratory tract that is caused by the gram-negative bacterium Bordetella pertussis. Although acellular pertussis (aP) vaccines are safe, they are not fully effective and thus require improvement. In contrast to whole-cell pertussis (wP) vaccines, aP vaccines do not contain lipopolysaccharide (LPS). Monophosphoryl lipid A (MPL) and Neisseria meningitidis LpxL2 LPS have been shown to display immune-stimulating activity while exerting little endotoxin activity. Therefore, we evaluated whether these LPS analogs could increase the efficacy of the aP vaccine. Mice were vaccinated with diphtheria-tetanus-aP vaccine with aluminum, MPL, or LpxL2 LPS adjuvant before intranasal challenge with B. pertussis. Compared to vaccination with the aluminum adjuvant, vaccination with either LPS analog resulted in lower colonization and a higher pertussis toxin-specific serum immunoglobulin G level, indicating increased efficacy. Vaccination with either LPS analog resulted in reduced lung eosinophilia, reduced eosinophil numbers in the bronchoalveolar lavage fluid, and the ex vivo production of interleukin-4 (IL-4) by bronchial lymph node cells and IL-5 by spleen cells, suggesting reduced type I hypersensitivity. Vaccination with either LPS analog increased serum IL-6 levels, although these levels remained well below the level induced by wP, suggesting that supplementation with LPS analogs may induce some reactogenicity but reactogenicity considerably less than that induced by the wP vaccine. In conclusion, these results indicate that supplementation with LPS analogs forms a promising strategy that can be used to improve aP vaccines.
AC-DC system power flow control by PWM converter (1990)

Developments in gate/base turn-off semiconductor devices with high power handling capabilities, principally the gate turn-off thyristor (GTO), have led to compact self-commutating converter circuits being widely used for applications such as AC drives, where control of the AC voltage and frequency at the motor terminals are needed. The converter operates as an inverter to supply power from the DC source to the motor, or with reversed power flow as a rectifier for braking. Additionally, pulse width modulation (PWM) can be employed for variation of the AC voltage and improving the generated AC voltage and current waveforms. Operation is again in two quadrants, but power reversal is by reversal of the direct current, not the voltage, which is much more convenient. The use of such a converter is considered as an alternative to that controlled by firing delay for long term bidirectional control of power flow between live AC and DC systems.
Adjuvant therapy for colorectal cancer (1997)

In recent years, adjuvant therapy for colorectal cancer has advanced considerably. This article reviews these advances and provides an update of the most recent and ongoing trials. In 1990, adjuvant therapy became the "standard of care" for patients with Stage III colon cancer (Dukes C) in the United States. Recent clinical trial data indicate that adjuvant treatment may also be effective in patients with Stage II (Dukes B2) colon cancer. The combination of 5-fluorouracil plus leucovorin may slightly improve survival (5-10 percent) compared with the standard 5-fluorouracil plus levamisole combination. The three-drug regimen (5-fluorouracil plus levamisole plus leucovorin) is more toxic, with no superior effect on survival. Intraportal chemotherapy, although it may significantly improve patient survival, does not decrease the frequency of liver metastases. However, it is still a promising form of adjuvant therapy owing to its short treatment period and relatively equivalent effects in survival compared with that of systemic therapy. For patients with Stage II or Stage III rectal cancer, postoperative systemic 5-fluorouracil plus radiation therapy plus protracted venous 5-fluorouracil infusion is the most effective postoperative adjuvant regimen. However, results from several studies show that preoperative radiation alone or chemoradiation for advanced local rectal cancers might also be effective while also improving resectability, decreasing morbidity, and increasing the chance that a sphincter-sparing procedure may be performed. The role of leucovorin in rectal cancer remains to be determined. Immune therapies with agents such as interferon-alpha-2a, monoclonal antibody 17-1A, and autologous tumor vaccines are being assessed and could further improve survival.
Statistical intensity variation analysis for rapid volumetric imaging of capillary network flux (2014)

We present a novel optical coherence tomography (OCT)-based technique for rapid volumetric imaging of red blood cell (RBC) flux in capillary networks. Previously we reported that OCT can capture individual RBC passage within a capillary, where the OCT intensity signal at a voxel fluctuates when an RBC passes the voxel. Based on this finding, we defined a metric of statistical intensity variation (SIV) and validated that the mean SIV is proportional to the RBC flux [RBC/s] through simulations and measurements. From rapidly scanned volume data, we used Hessian matrix analysis to vectorize a segment path of each capillary and estimate its flux from the mean of the SIVs gathered along the path. Repeating this process led to a 3D flux map of the capillary network. The present technique enabled us to trace the RBC flux changes over hundreds of capillaries with a temporal resolution of ~1 s during functional activation.
Stable Isotopes in Sedimentary Geology (1983)

Stable isotope geochemistry has come into its own in the last few years as our inventory of processes and materials has improved from the result of much basic research. Stable isotope techniques should become a standard application to most studies of sedimentary rocks and depositional environments; it has much application in exploration for hydrocarbons as well as in basic research. Rapid progress depends on adequate and proper education of professionals in the techniques, the correct selection of samples, consideration of problems of interpretation, and concern for other types of data required to constrain interpretation of stable isotopic data. This text is designed to deal with the application of stable isotopes to geologic problems.
Use of Mensuration in Quantities (1966)

mensuration is concerned with the measurement of areas and volumes of triangles, rectangles, circles, etc., and some basic knowledge of this subject is required by all quantity surveying students. This chapter sets out to explain how the principles of mensuration are used in the measurement of building quantities.
Toward practical holey fiber technology:?fabrication, splicing, modeling, and characterization (1999)

We report the fabrication of long lengths of mechanically robust holey fiber and what is believed to be the first demonstration of their splicing. These practical advances have permitted what is to our knowledge the first detailed characterization of a holey fiber near 1.5mum . We compare dispersion measurements with our numerical predictions and confirm that our model can be used to predict accurately holey fiber properties.
N-Terminal Pro-B-Type Natriuretic Peptide Is a Major Predictor of the Development of Atrial Fibrillation (2009)

In a community-based population of older adults, NT-proBNP was a remarkable predictor of incident AF, independent of any other previously described risk factor.
Go reconfigure [programmable logic in handheld devices] (2003)

The article discusses why only programmable handheld devices can do the job of any 10 different gizmos. The development of a chameleon-like handheld device is also described. The programmable logic device (PLD), a semiconductor containing a personalization memory and logic elements, can make it possible to have a pocket-electronics device consolidated with a number of features including adaptability to any network, capability to fit new standards, and having an upgradeable security system for the latest virus. Conventional PLDs are big, slow, power hungry, and expensive, but, like the microprocessors, PLDs can evolve in time into higher-level logic primitives that make them suitable for untethered applications.
NO‐sulindac inhibits the hypoxia response of PC‐3 prostate cancer cells <i>via</i> the Akt signalling pathway (2008)

Nitric oxide-donating non-steroidal anti-inflammatory drugs are safer than traditional NSAIDs and inhibit the growth of prostate cancer cells with greater potency than NSAIDs. In vivo, prostate cancer deposits are found in a hypoxic environment which induces resistance to chemotherapy. The aim of this study was to assess the effects and mechanism of action of a NO-NSAID called NO-sulindac on the PC-3 prostate cancer cell line under hypoxic conditions. NO-sulindac was found to have pro-apoptotic, cytotoxic, and anti-invasive effect on PC-3 cells under normoxia and hypoxia. NO-sulindac was significantly more cytotoxic than sulindac at all oxygen levels. The sulindac/linker and NO-releasing subunits both contributed to the cytotoxic effects of NO-sulindac. Resistance of PC-3 cells to NO-sulindac was induced as the oxygen concentration declined. Hypoxia-induced chemoresistance was reversed by knocking-down hypoxia-inducible factor-1alpha (HIF-1alpha) mRNA using RNAi. Nuclear HIF-1alpha levels were upregulated at 0.2% oxygen but reduced by treatment with NO-sulindac, as was Akt phosphorylation. NO-sulindac treatment of hypoxic PC-3 cells transfected with a reporter construct, downregulated activation of the hypoxia response element (HRE) promoter. Co-transfection of PC-3 cells with the HRE promoter reporter construct and myr-Akt (constitutively active Akt) plasmids reversed the NO-sulindac induced reduction in HRE activation. Real-time polymerase chain reaction analysis of hypoxic, NO-sulindac treated PC-3 cells showed downregulation of lysyl oxidase and carbonic anhydrase IX mRNA expression. Collectively, these novel findings demonstrate that NO-sulindac directly inhibits the hypoxia response of PC-3 prostate cancer cells by inhibiting HIF-1alpha translation via the Akt signalling pathway. The ability of NO-sulindac to inhibit tumour adaption to hypoxia has considerable relevance to the future management of prostate cancer with the same cellular properties as PC-3.
Synthesis and regulation of extracellular β (1–3) glucanase and protease by <i>cytophaga</i> sp. In batch and continuous culture (1986)

Lytic enzyme systems with the ability to break whole cells of yeast are a mixture of several enzymes and virtually all contain beta(1-3)glucanases and some protease. It appears that the presence of these two enzyme activities is necessary to break the two layers of the rigid cell wall. The enzyme system of Cytophaga NCIB 9497 has a high activity towards the walls of yeast and also of bacteria. This article describes the production of this extracellular lytic enzyme system in batch and continuous culture-it was found to be inducible. The synthesis and regulation of the two main constituent enzymes, beta(1-3)glucanase and protease, have been investigated. The synthesis of beta(1-3)glucanase is regulated by bothinduction (by an unknown inducer) and catabolite repression. Highbeta(1-3)glucanase activities were obtained in continuous culture at low dilution rates over a narrow range (0.05-0.10 h(-1)), and there is evidence of the presence of more than one glucanase enzyme. Proteolytic activity appears subject to catabolite repression and made up of the activities of more than one protease enzyme. Productivity and enzyme concentration were increased several fold in continuous culture when compared to batch culture.
An incremental version of iterative data flow analysis (1989)

A technique is presented for incrementally updating solutions to both union and intersection data-flow problems in response to program edits and transformations. For generality, the technique is based on the iterative approach to computing data-flow information. The authors show that for both union and intersection problems, some changes can be incrementally incorporated immediately into the data-flow sets while others are handled by a two-phase approach. The first phase updates the data-flow sets to overestimate the effect of the program change, enabling the second phase to incrementally update the affected data-flow sets to reflect the actual program change. An important problem that is addressed is the computation of the data-flow changes that need to be propagated throughout a program, based on different local code changes. The technique is compared to other approaches to incremental data-flow analysis.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lunar rock types - The role of plagioclase in non-mare and highland rock types (1973)

Some nonmare and highland rock types (14310 type KREEP and very high Al2O3 basalts) have the internal chemical variations expected for a plagioclase-liquid system. The observed Eu variations in these rock types suggest a D(Eu) 1/p of 0.6 to 0.7. The Sr variations suggest a D(Sr) 1/p of about 0.6, with values as low as 0.35 suggested for some materials from sample 14063. Common Apollo 14 KREEP and Apollo 15 KREEP do not show internal Sr, Eu, Al2O3 variations consistent with the D(Eu, Sr) 1/p values derived for 14310 type KREEP. Major element and experimental data indicate that olivine or pyroxene is a large, perhaps dominant, controller of chemical variations within common Apollo 14 KREEP. The application of these distribution coefficients to pure anorthosites like 15415 yields the model dependent conclusion that the silicate liquids with which such anorthosites may have been chemically equilibrated have not yet been analyzed and perhaps not directly sampled.
"B.N.C." (1906)

"B.N.C." Get access H. C-N. H. C-N. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s10-V, Issue 108, 20 January 1906, Page 46, https://doi.org/10.1093/nq/s10-V.108.46a Published: 20 January 1906
Virtual reality for interactive binocular treatment of amblyopia (2006)

Amblyopia, or ‘lazy eye’, is currently treated by wearing an adhesive patch over the nonamblyopic eye for several hours per day, over a period of many months. Non-compliance with patch wearing is a significant problem. Our multi-displinary team involved clinicians and technologists to investigate the application of VR technology in a novel way. We devised a binocular treatment system in which children watch a video clip of a cartoon on a virtual TV screen, followed by playing an interactive computer game to improve their vision. So far the system has been used to treat 39 children of which 87% have shown some improvement in vision. Vision improvement tended to occur within the first 3-4 treatment sessions. This paper describes research development of the I-BiT™ system. We present a summary of results from clinical case studies conducted to date and discuss the implications of these findings with regard to future treatment of amblyopia.
Cytokine patterns in cancer patients: A review of the correlation between interleukin 6 and prognosis (2016)

Closely associated with the patient's clinical condition and independent of the cancer histology, the increased IL-6 serum level uniformly appears to correlate with survival as paraneoplastic condition in later cancer stages independent of the cancer type. Modifications of this paraneoplastic immune reaction may offer new therapeutic options in cancer.
A Synthetic Analogue of the Active Site of Fe-Containing Nitrile Hydratase with Carboxamido N and Thiolato S as Donors:  Synthesis, Structure, and Reactivities (2001)

As part of our work on models of the iron(III) site of Fe-containing nitrile hydratase, a designed ligand PyPSH(4) with two carboxamide and two thiolate donor groups has been synthesized. Reaction of (Et(4)N)[FeCl(4)] with the deprotonated form of the ligand in DMF affords the mononuclear iron(III) complex (Et(4)N)[Fe(III)(PyPS)] (1) in high yield. The iron(III) center is in a trigonal bipyramidal geometry with two deprotonated carboxamido nitrogens, one pyridine nitrogen, and two thiolato sulfurs as donors. Complex 1 is stable in water and binds a variety of Lewis bases at the sixth site at low temperature to afford green solutions with a band around 700 nm. The iron(III) centers in these six-coordinate species are low-spin and exhibit EPR spectra much like the enzyme. The pK(a) of the water molecule in [Fe(III)(PyPS)(H(2)O)](-) is 6.3 +/- 0.4. The iron(III) site in 1 with ligated carboxamido nitrogens and thiolato sulfurs does not show any affinity toward nitriles. It thus appears that at physiological pH, a metal-bound hydroxide promotes hydration of nitriles nested in close proximity of the iron center in the enzyme. Redox measurements demonstrate that the carboxamido nitrogens prefer Fe(III) to Fe(II) centers. This fact explains the absence of any redox behavior at the iron site in nitrile hydratase. Upon exposure to limited amount of dioxygen, 1 is converted to the bis-sulfinic species. The structure of the more stable O-bonded sulfinato complex (Et(4)N)[Fe(III)(PyP[SO(2)](2))] (2) has been determined. Six-coordinated low-spin cyanide adducts of the S-bonded and the O-bonded sulfinato complexes, namely, Na(2)[Fe(III)(PyP[SO(2)](2))(CN)] (4) and (Et(4)N)(2)[Fe(III)(PyP[SO(2)](2))(CN)] (5), afford green solutions in water and other solvents. The iron(II) complex (Et(4)N)(2)[Fe(II)(PyPS)] (3) has also been isolated and structurally characterized.