gebhart/patrepeval huggingface dataset:
Adjustment of the bioresistivity by electron irradiation: self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols with embedded cleavable group (2009)

The bioresistivity of protein-repelling films, such as e.g. oligoethyleneglycol (OEG) bearing self-assembled monolayers (SAMs), can be adjusted by electron irradiation. We have studied the effect of an embedded irradiation-sensitive functional group (so called "weak link") on the irradiation sensitivity of such films. As test systems, we used two OEG-substituted alkanethiolate SAMs with different lengths of the OEG chain and a sulfone group serving as a "weak link" moiety; this group was embedded between the OEG and alkyl chains of the target molecules. The expected cleavage of the molecular chains at the predetermined "weak link" position was found to be accompanied by direct damage of the OEG matrix, with a dominance of the latter process in the case of a long OEG chain. At the same time, in the case of short OEG chain, the insertion of sulfone group resulted in a noticeable gain in the irradiation sensitivity of the respective SAMs and, consequently, in enhanced tunability of their protein-adhesive properties. These films, along with other OEG-substituted SAMs and polymer layers with and without an embedded weak link moiety, can be used as primary matrices for the fabrication of different protein patterns by electron beam lithography.
NeuTM: A neural network-based framework for traffic matrix prediction in SDN (2018)

This paper presents NeuTM, a framework for network Traffic Matrix (TM) prediction based on Long Short-Term Memory Recurrent Neural Networks (LSTM RNNs). TM prediction is defined as the problem of estimating future network traffic matrix from the previous and achieved network traffic data. It is widely used in network planning, resource management and network security. Long Short-Term Memory (LSTM) is a specific recurrent neural network (RNN) architecture that is well-suited to learn from data and classify or predict time series with time lags of unknown size. LSTMs have been shown to model longrange dependencies more accurately than conventional RNNs. NeuTM is a LSTM RNN-based framework for predicting TM in large networks. By validating our framework on real-world data from GEANT network, we show that our model converges quickly and gives state of the art TM prediction performance.
Human Mast Cells Augment Fibroblast Proliferation by Heterotypic Cell-Cell Adhesion and Action of IL-4 (1998)

Mast cells have been implicated in the pathogenesis of fibrosis because of their increased number in chronic inflammatory reactions. In a previous study, we had shown that human mast cells readily attach and form heterotypic cell-cell contacts when seeded on top of fibroblast monolayers. Here, we report that human mast cells stimulate fibroblast proliferation after cell-cell contact. Proliferation was measured by 5-bromo-2'-deoxyuridine or [3H]thymidine uptake of subconfluent fibroblast monolayers after attachment of mast cells that had been preincubated with mitomycin C. An 18-h coculture of the human mast cell line HMC-1 doubled proliferation of normal skin fibroblasts. Moreover, normal mast cells prepared from neonatal foreskin doubled fibroblast proliferation. The stimulatory effect was dependent on heterotypic cell-cell contact since it was not transferred by tissue culture supernatants from mast cells. We hypothesized that mast cell cytokines secreted after heterotypic cell-cell contact stimulate fibroblast proliferation. Several mast cell-derived cytokines were tested for effects on fibroblast proliferation. Only IL-4 was able to double fibroblast proliferation. Additional experiments revealed that: 1) the stimulatory effect of IL-4 as well as of the mast cell coculture could be completely abrogated by preincubation of fibroblasts with an anti-IL-4R mAb blocking ligand binding; 2) mast cell-derived IL-4 acts as a second signal for fibroblasts since it amplifies the action of low doses of obligatory fibroblast growth factors such as fibroblast growth factor or platelet-derived growth factor.
<i>The Advisors: Oppenheimer, Teller and the Superbomb</i> (1976)

Contents Chapter ONE Chapter TWO Chapter THREE Chapter FOUR Chapter FIVE Chapter SIX Chapter SEVEN Appendix I Appendix II
Generation of Functional Coatings on Hydrophobic Surfaces through Deposition of Denatured Proteins Followed by Grafting from Polymerization (2012)

Hydrophilic coatings were produced on flat hydrophobic substrates featuring n-octadecyltrichlorosilane (ODTS) and synthetic polypropylene (PP) nonwoven surfaces through the adsorption of denatured proteins. Specifically, physisorption from aqueous solutions of α-lactalbumin, lysozyme, fibrinogen, and two soy globulin proteins (glycinin and β-conglycinin) after chemical (urea) and thermal denaturation endowed the hydrophobic surfaces with amino and hydroxyl functionalities, yielding enhanced wettability. Proteins adsorbed strongly onto ODTS and PP through nonspecific interactions. The thickness of adsorbed heat-denatured proteins was adjusted by varying the pH, protein concentration in solution, and adsorption time. In addition, the stability of the immobilized protein layer was improved significantly after interfacial cross-linking with glutaraldehyde in the presence of sodium borohydride. The amino and hydroxyl groups present on the protein-modified surfaces served as reactive sites for the attachment of polymerization initiators from which polymer brushes were grown by surface-initiated atom-transfer radical polymerization of 2-hydroxyethyl methacrylate. Protein denaturation and adsorption as well as the grafting of polymeric brushes were characterized by circular dichroism, ellipsometry, contact angle, and Fourier transform infrared spectroscopy in the attenuated total reflection mode.
Scanning the Technology: Applications of Asynchronous Circuits (1999)

A comparison with synchronous circuits suggests four opportunities for the application of asynchronous circuits: high performance, low power, improved noise and electromagnetic compatibility (EMC) properties, and a natural match with heterogeneous system timing. In this overview article each opportunity is reviewed in some detail, illustrated by examples, compared with synchronous alternatives, and accompanied by numerous pointers to the literature. Conditions for applying asynchronous circuit technology, such as the existence and availability of computer-aided design (CAD) tools, circuit libraries, and effective test approaches, are discussed briefly. Asynchronous circuits do offer advantages for many applications, and their design methods and tools are now starting to become mature. Keywords—Asynchronous circuits, asynchronous systems, CAD tools, heterogeneous timing, high performance, low power, low
Relational Storage for XML Rules (2012)

Very few research works have been done on XML security over relational databases despite that XML became the de facto standard for the data representation and exchange on the internet and a lot of XML documents are stored in RDBMS. In However, the proposed algorithms had performance drawbacks. In this paper, we will use the same access control model of The mapping of the XML DTD to relational schema is proposed in We also propose an algorithm to translate XPath queries to SQL queries based on the mapping algorithm in
The nature of autocatalysis in the Butlerov reaction (2007)

The effect of the nature of an initiator on the kinetics of formaldehyde consumption and on product composition in the Butlerov reaction was studied in a stirred flow reactor and a batch reactor. It was found that, under flow conditions, the kinetics and the product composition of this reaction are independent of the nature of the initiator. The reaction schemes proposed previously for an autocatalytic process mechanism based on the formation of glycolaldehyde from two formaldehyde molecules are incorrect. A correlation between the initiating activities of various monosaccharides and the rates of their conversion into an enediol form was found with the use of a batch reactor. Solid enediol complexes with Ca2+ ions were isolated for glucose, fructose, ribose, and sorbose; the initiating activity of these complexes was found to be much higher than the initiating activity of pure monosaccharides. A self-consistent mechanism was proposed for Butlerov reaction initiation. The formation of the enediol forms of monosaccharides followed by degradation to lower carbohydrates plays a key role in this mechanism. In turn, the initiating activity depends on the position of the carbonyl group in the monosaccharide molecule. The condensation reactions of glycolaldehyde, glyceraldehyde, and dihydroxyacetone with each other were studied. Based on data on the condensation products of lower carbohydrates, a scheme was proposed for the Butlerov reaction. According to this reaction scheme, C2 and C3 carbohydrates mainly undergo an aldol condensation reaction with formaldehyde, whereas the formation of higher monosaccharides occurs by the aldol condensation of lower C2–C3 carbohydrates with each other.
Calculation of x‐ray fluorescence intensities from bulk and multilayer samples (1990)

Abstract Equations are derived for the calculation of x‐ray fluorescence intensities from bulk and multilayer samples. Both intra‐ and interlayer secondary fluorescence intensities are expressed analytically, in terms of the exponential‐integral function. It is shown that calculations are performed much faster with this method than with a previous method using numerical integration. As an illustration, some examples of intensity calculations are given for a thin layer on a substrate.
HSV: immunopathological aspects of HSV infection (2007)

Foreign material entering multicellular organisms triggers a range of defense reactions which, when successful, subjugates and removes the invaders. Invertebrates and plants have natural defense systems, which recognize commonly shared patterns and usually react in a stereotypical manner. Long-lived animals such as vertebrates add to these natural defenses with adaptive systems that show discriminating recognition machinery, complex and varying effector mechanisms and development of persistent or “memory” responses. Under ideal circumstances, immune defense proceeds with minimal or inapparent damage to the host. In other situations, the defense system is less successful and the host tissues become damaged by the reaction. We usually consider the former situation as immunity and the latter as immunopathology. However, in both instances, mechanisms at play may be similar and deciding if the process is one or the other may require Lucretian logic.
Protected mode software architecture (1996)

From the Publisher:
Anyone writing real-time operating systems, multi-task operating systems, or device drivers for these systems needs to be able to do assembly language protected-mode programming. Protected Mode Software Architecture helps readers understand the problems that single-task and multitasking operating systems must deal with, and then examines each component of both the real and protected mode software architectures of the post-286 Intel processors.
Novel Segmentation Method for Fractal Geometry Based Satellite Images Classification (2017)

The use of efficient image classification methods gains most interest due to its close relation with the improvements happen in the fields of compression and communications. Fractal geometry is receiving increased attention as a quantitative and qualitative model for natural phenomena description, which can establish an active classification technique when applied on satellite image. In this paper, the used satellite image is taken by Landsat for Al-Kut city in Iraq. Different parts of this image that contains different visible classes are chosen manually to be a training area . The training areas are passing two stages: segmentation and classification. To credit effective segmentation, the training areas are segmented by a hybrid technique consists of two sequenced methods: Diagonal ( Dg ) method that operated inside the quadtree ( Q ) method. The hybrid method segments each squared image block into either four quadrants or two triangular blocks according to uniformity criterion. Then, unsupervised classification is applied depending on the fractal feature. The fractional Brownian motion ( FBM ) is the fractal feature that employed for classification. The classification is implemented for each image segment; squared or triangular. The results of FBM are grouped into five deferent clusters, each represents distinct class of image. The center of each group and its dispersion distance are stored in a database table to be used in the classification of whole image. The classification results gave 95% classification score, which ensures the ability of FBM to recognize different satellite image regions when used as fractal feature.
<title>Comprehensive approach to breast cancer detection using light: photon localization by ultrasound modulation and tissue characterization by spectral discrimination</title> (1993)

A new technique called Ultrasound Tagging of Light (UTL) for imaging breast tissue is described. In this approach, photon localization in turbid tissue is achieved by cross- modulating a laser beam with focussed, pulsed ultrasound. Light which passes through the ultrasound focal spot is `tagged' with the frequency of the ultrasound pulse. The experimental system uses an Argon-Ion laser, a single PIN photodetector, and a 1 MHz fixed-focus pulsed ultrasound transducer. The utility of UTL as a photon localization technique in scattering media is examined using tissue phantoms consisting of gelatin and intralipid. In a separate study, in vivo optical reflectance spectrophotometry was performed on human breast tumors implanted intramuscularly and subcutaneously in nineteen nude mice. The validity of applying a quadruple wavelength breast cancer discrimination metric (developed using breast biopsy specimens) to the in vivo condition was tested. A scatter diagram for the in vivo model tumors based on this metric is presented using as the `normal' controls the hands and fingers of volunteers. Tumors at different growth stages were studied; these tumors ranged in size from a few millimeters to two centimeters. It is expected that when coupled with a suitable photon localization technique like UTL, spectral discrimination methods like this one will prove useful in the detection of breast cancer by non-ionizing means.
The role of the cellular antioxidant defense in oxidant carcinogenesis. (1994)

Oxidant carcinogens interact with multiple cellular targets including membranes, proteins, and nucleic acids. They cause structural damage to DNA and have the potential to mutate cancer-related genes. At the same time, oxidants activate signal transduction pathways and alter the expression of growth- and differentiation-related genes. Indeed, the carcinogenic action of oxidants results from the superposition of these genetic and epigenetic effects. All cells possess elaborate antioxidant defense systems that consist of interacting low and high molecular weight components. Among them, superoxide dismutases (SOD), glutathione peroxidases (GPx), and catalase (CAT) play a central role. Our studies with mouse epidermal cells demonstrate that the balance between several antioxidant enzymes rather than the activity of a single component determines the degree of protection. Unexpectedly, increased levels of Cu,Zn-SOD alone in stable transfectants resulted in sensitization to oxidative chromosomal aberrations and DNA strand breaks. However, a concomitant increase in CAT or GPx in double transfectants corrected or overcorrected the hypersensitivity of the SOD clones depending on the ratios of activities CAT/SOD or GPx/SOD. The cellular antioxidant capacity also affected oxidant induction of the growth-related immediate early protooncogene c-fos. Increases in CAT or SOD reduced the accumulation of c-fos message, albeit for different reasons. The cellular antioxidant defense also affects the action of UVB light (290-320 nm) that represents the most potent carcinogenic wavelength range of the solar spectrum. UVB light is known to exert its action in part through oxidative mechanisms. Increases in CAT and GPx protected mouse epidermal cells from UVB-induced DNA breakage.(ABSTRACT TRUNCATED AT 250 WORDS)
[Uteroglobin]. (1980)

Uteroglobin has been studied under two aspects: 1) as a model of specific interaction between a protein and a steroid hormone: crystals were obtained and analyzed by X-ray diffraction; 2) as a marker of progesterone action in the endometrium: messenger RNA was translated, purified and transcribed into complementary DNA.
Systemic Administration of an Antagomir Designed to Inhibit miR-92, a Regulator of Angiogenesis, Failed to Modulate Skeletal Anabolic Response to Mechanical Loading (2013)

The goal of this study is to evaluate if promotion of angiogenesis by systemic treatment with an antagomir against miR-92a, a well established inhibitor of angiogenesis, will maximize the benefits of exercise on bone. Ten week old female C57BL6/J mice were subjected to two weeks of external load by four point bending. During the first week of mechanical loading (ML), mice were injected (2.7 mg/kg of bodyweight) with antagomir against miR-92 or control antagomir (3 alternate days via retro-orbital). No difference in tissues weights (heart, kidney, liver) were found in mice treated with miR-92 vs. control antagomir suggesting no side effects. Two weeks of ML increased tibia TV, BV/TV and density by 6-15 %, as expected, in the control antagomir treated mice. Similar increases in the above parameters (7-16 %) were also seen in mice treated miR-92 antagomir. Administration of miR-92 antagomir was effective in reducing levels of mir-92 in heart, liver and skeletal muscle and in contrast, expression levels of two other microRNA's miR-93 and miR-20a remain constant, thus suggesting specificity of the antagomir used. Surprisingly, we failed to detect significant changes in the expression levels of vascular genes (VEGF, CD31 and Tie2) in heart, liver or skeletal muscle. Based on these findings, we conclude that systemic administration of antagomir against miR-92 while reduced expression levels of miR-92 in the tissues; it did not significantly alter either angiogenic or osteogenic response, thus suggesting possible redundancy in miR-92 regulation of angiogenesis.
New Compounds. Some New Compounds as Possible Insect Repellents (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Compounds. Some New Compounds as Possible Insect RepellentsMelvin Newman, Barney Magerlein, and William WheatleyCite this: J. Am. Chem. Soc. 1946, 68, 10, 2112–2115Publication Date (Print):October 1, 1946Publication History Published online7 November 2002Published inissue 1 October 1946https://pubs.acs.org/doi/10.1021/ja01214a602https://doi.org/10.1021/ja01214a602research-articleACS PublicationsRequest reuse permissionsArticle Views235Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fatty acids : their chemistry, properties, production, and uses (1960)

Fatty acids: their chemistry, properties, production, and uses , Fatty acids: their chemistry, properties, production, and uses , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Viral dynamics in vivo: limitations on estimates of intracellular delay and virus decay. (1996)

Anti-viral drug treatment of human immunodeficiency virus type I (HIV-1) and hepatitis B virus (HBV) infections causes rapid reduction in plasma virus load. Viral decline occurs in several phases and provides information on important kinetic constants of virus replication in vivo and pharmacodynamical properties. We develop a mathematical model that takes into account the intracellular phase of the viral life-cycle, defined as the time between infection of a cell and production of new virus particles. We derive analytic solutions for the dynamics following treatment with reverse transcriptase inhibitors, protease inhibitors, or a combination of both. For HIV-1, our results show that the phase of rapid decay in plasma virus (days 2-7) allows precise estimates for the turnover rate of productively infected cells. The initial quasi-stationary phase (days 0-1) and the transition phase (days 1-2) are explained by the combined effects of pharmacological and intracellular delays, the clearance of free virus particles, and the decay of infected cells. Reliable estimates of the first three quantities are not possible from data on virus load only; such estimates require additional measurements. In contrast with HIV-1, for HBV our model predicts that frequent early sampling of plasma virus will lead to reliable estimates of the free virus half-life and the pharmacological properties of the administered drug. On the other hand, for HBV the half-life of infected cells cannot be estimated from plasma virus decay.
Logic synthesis of synchronous parallel controllers (2002)

The contribution of this work is a VHDL methodology for the design of synchronous parallel controllers that supports RTL representation and verification, state assignment and decomposition, logic synthesis, and gate-level consistency checking. A simple extension to FSM techniques, based on Petri nets, is used to represent concurrency and check for parallel synchronization errors; the concept of synchronous-safeness is introduced to enable maximum latching of data path units. A synthesizable VHDL template is described in which ASSERTION statements are used to enable the syntactic and semantic correctness of the model to be tested in unison. The method yields more efficient implementations than FSM designs when concurrency forms part of the specification, and in a practical design, a 50% area reduction and 40% speed improvement over the best FSM synthesis were achieved.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Characteristics of Ultrathin Lanthanum Oxide Films on Germanium Substrate: Comparison with Those on Silicon Substrate (2007)

Ultrathin La2O3 films deposited on Ge substrates were characterized. The films were deposited by electron-beam evaporation in an ultrahigh vacuum system and were subjected to post-deposition annealing at various temperatures in N2 ambient. There was little interfacial layer growth at the interface of La2O3/Ge, which was confirmed by transmission electron microscopy and spectroscopic ellipsometry. Electrical measurements revealed that a small capacitance equivalent thickness of 1.48 nm with a leakage current density of 6 ×10-7 A/cm2 at 1 V was achieved using a Pt/La2O3/Ge structure by post-deposition annealing at 600 °C. This result suggests that ultrathin La2O3 films can be grown on a Ge substrate by annealing at a sufficiently high temperature for activating the source and drain regions for a Ge metal–oxide–semiconductor field-effect transistor.